[
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1=C(C)C(=O)C(C(CCC(=O)O)c2ccccc2)=C(C)C1=O.CCO.O=S(Cl)Cl>>CCOC(=O)CCC(C1=C(C)C(=O)C(C)=C(C)C1=O)c1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrBr.ClC(Cl)(Cl)Cl.c1ccc(CC2Cc3ccccc3O2)cc1>>Brc1ccc2c(c1)CC(Cc1ccccc1)O2",
        "output": "98"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cl.Cn1c(C2CC(C=O)C2)nc2ccc(Br)cc21.NO>>Cn1c(C2CC(C=NO)C2)nc2ccc(Br)cc21",
        "output": "118"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "NC(=O)CC[C@H](N)C(=O)O.NC(=O)[C@H](CCC(=O)O)NC(=O)Cc1ccccc1.O=C(Cl)Cc1ccccc1>>NC(=O)CC[C@H](NC(=O)Cc1ccccc1)C(=O)O",
        "output": "585"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.CCOC(=O)CC1OB(O)c2cc(Oc3cnccn3)cc(OCc3ccccc3)c21.[Pd]>>CCOC(=O)CC1OB(O)c2cc(Oc3cnccn3)cc(O)c21",
        "output": "23"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCBr.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].[Cs+].[Cs+].c1ccc2c(c1)[nH]c1ccccc12>>CCCCCn1c2ccccc2c2ccccc21",
        "output": "470"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(C(=O)Cl)cc1.I.Nc1nc2c(s1)Cc1ccccc1-2>>Cc1ccc(C(=O)Nc2nc3c(s2)Cc2ccccc2-3)cc1",
        "output": "673"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(COc2ccc(C(=O)O)cc2)CC1.CC(C)(C)c1ccccc1N1CCNCC1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.O.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCC(COc2ccc(C(=O)N3CCN(c4ccccc4C(C)(C)C)CC3)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.Cc1ccc(CNC2CCN(C(=O)OC(C)(C)C)CC2)cc1OC(F)(F)F.Cl.ClCCl>>Cc1ccc(CNC2CCNCC2)cc1OC(F)(F)F",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCc1cc(C(=O)OC)ccc1C.CCO.NN.O>>C=CCc1cc(C(=O)NN)ccc1C",
        "output": "421"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.ClC(Cl)Cl.NN.O.O=C(Nc1cccc(CCN2C(=O)c3ccccc3C2=O)n1)Nc1csc(-c2ccncc2)n1>>NCCc1cccc(NC(=O)Nc2csc(-c3ccncc3)n2)n1",
        "output": "242"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.Cc1nc2c(C(F)(F)F)cccc2n1-c1cccc(O)c1.ClCCl.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1nc2c(C(F)(F)F)cccc2n1-c1cccc(OS(=O)(=O)C(F)(F)F)c1",
        "output": "731"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(O)C(=O)O.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.ClCCl.F[P-](F)(F)(F)(F)F.c1ccc(-c2nc3c(o2)CNCC3)cc1>>CCC(O)C(=O)N1CCc2nc(-c3ccccc3)oc2C1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOCC.COc1ccc(-n2nc(CC(C(=O)O)c3cccc(C)c3)cc2-c2ccc(Cl)c(Cl)c2)cc1.O=C([O-])[C@H](O)[C@@H](O)C(=O)[O-].[H-].[K+].[Na+]>>COc1ccc(-n2nc(CC(CO)c3cccc(C)c3)cc2-c2ccc(Cl)c(Cl)c2)cc1",
        "output": "231"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.Fc1ccc(Cc2cc(-c3ccncc3)nn2C2CNC2)cc1>>CS(=O)(=O)N1CC(n2nc(-c3ccncc3)cc2Cc2ccc(F)cc2)C1",
        "output": "584"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "B.C1CCOC1.C1CCOC1.CNC(=O)COCCOc1ccc([N+](=O)[O-])cc1>>CNCCOCCOc1ccc([N+](=O)[O-])cc1",
        "output": "112"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.COc1ccccc1N1CCN(CCCCN2C(=O)CN(CCO)C2=O)CC1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>COc1ccccc1N1CCN(CCCCN2C(=O)CN(CCOS(=O)(=O)c3ccc(C)cc3)C2=O)CC1",
        "output": "197"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)CN.FC(F)(F)c1cccc(Cl)n1>>CC(C)(C)CNc1cccc(C(F)(F)F)n1",
        "output": "70"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "OB(O)c1ccccc1.OC1CCN(c2cc(-c3ccccc3)nc(Cl)n2)CC1>>OC1CCN(c2cc(-c3ccccc3)nc(-c3ccccc3)n2)CC1",
        "output": "874"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)c1csc(NC)n1.O.[Li+].[OH-]>>CNc1nc(C(=O)O)cs1",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cl.Nc1ccccc1N.O=C(O)CCCl>>ClCCc1nc2ccccc2[nH]1",
        "output": "512"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCN1.CN(C)C=O.COc1ccc2c(Cc3c(Cl)cncc3Cl)nnc(Cl)c2c1.N#N>>COc1ccc2c(Cc3c(Cl)cncc3Cl)nnc(N3CCOCC3)c2c1",
        "output": "406"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.Cl.Cn1cnc(-c2ccc(NC(=C3C(=O)Oc4ccccc43)c3ccc(C(C)(C)NC(=O)OC(C)(C)C)cc3)cc2)c1>>Cn1cnc(-c2ccc(NC(=C3C(=O)Oc4ccccc43)c3ccc(C(C)(C)N)cc3)cc2)c1",
        "output": "793"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1c2n(c3c(Br)cc(C#N)cc13)CCNC2=O.OB(O)c1cc(Cl)cc(Cl)c1>>Cc1c2n(c3c(-c4cc(Cl)cc(Cl)c4)cc(C#N)cc13)CCNC2=O",
        "output": "833"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)/N=N/C(=O)OC(C)(C)C.OCCC1CC1.Oc1ccc2ccc3ccc(Br)cc3c2c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Brc1ccc2ccc3ccc(OCCC4CC4)cc3c2c1",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CN1CCC(COc2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1.[Pd]>>CN1CCC(COc2ccc(N)cc2C(F)(F)F)CC1",
        "output": "202"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)CC(=O)Cl.Cc1nc(-c2sc(N)nc2-c2ccccc2)no1>>Cc1nc(-c2sc(NC(=O)CC(C)(C)C)nc2-c2ccccc2)no1",
        "output": "553"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1ncc2c(cc(-c3cccc(C(F)(F)F)c3)c(=O)n2Cc2ccccc2)c1O.C[O-].NCCCC(=O)O.O=C([O-])O.[Na+].[Na+]>>O=C(O)CCCNC(=O)c1ncc2c(cc(-c3cccc(C(F)(F)F)c3)c(=O)n2Cc2ccccc2)c1O",
        "output": "487"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CCOc1ccc2c(Cl)cn(CC(=O)OC(C)(C)C)c2c1.[Li+].[OH-]>>Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CCOc1ccc2c(Cl)cn(CC(=O)O)c2c1",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CN1CCCC1=O.Cc1ccc(N)cc1Oc1ccc2nc(NC(=O)C3CC3)nn2c1.N#CC1(c2cccc(C(=O)Cl)c2)CC1>>Cc1ccc(NC(=O)c2cccc(C3(C#N)CC3)c2)cc1Oc1ccc2nc(NC(=O)C3CC3)nn2c1",
        "output": "11"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCN(CC)CC.COC(=O)C(=O)[C@H](COCc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(OCc2ccccc2)cc1.Cl.ClC(Cl)Cl.ClCCl.Cn1cnc(C[C@H](NC(=O)OCc2ccccc2)C(=O)O)c1.On1nnc2ccccc21>>COC(=O)C(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@H](Cc1cn(C)cn1)NC(=O)OCc1ccccc1",
        "output": "133"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1[nH]c(C)c(C)c1O.ClCCBr.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1[nH]c(C)c(C)c1OCCCl",
        "output": "608"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1ccc2c(c1)nc(SCc1cccc(Br)c1)n2CCCN(C)CCc1ccccn1.O.[Li+].[OH-]>>CN(CCCn1c(SCc2cccc(Br)c2)nc2cc(C(=O)O)ccc21)CCc1ccccn1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1[N+](=O)[O-].[Ni]>>COc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1N",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCc1n[nH]c2cc(C(=O)O)ccc12.CN(C)c1ccncc1.CO.ClCCl.c1ccc2[nH]ncc2c1>>CCc1n[nH]c2cc(C(=O)OC)ccc12",
        "output": "195"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.CC(C)(C)c1cccc(C=O)c1O.ClCCl>>CC(C)(C)c1cc(Br)cc(C=O)c1O",
        "output": "98"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC(CCO)CC1.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CC(C)(C)OC(=O)N1CCC(CC=O)CC1",
        "output": "142"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCCO.COC(=O)c1c(C)cccc1COc1cc(C)c2nc(C)n(Cc3ccc(-c4ccccc4)cc3Cl)c2c1.Cl.[Na+].[OH-]>>Cc1cccc(COc2cc(C)c3nc(C)n(Cc4ccc(-c5ccccc5)cc4Cl)c3c2)c1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CNCCN1.Cc1nnc(-c2cccnc2Cl)o1>>Cc1nnc(-c2cccnc2N2CCNCC2)o1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCc1c(C)c(Cl)cc(C(C)C)c1O.Cc1c(Cl)cc(C(C)C)c2c1CC(CO)O2.Cc1ccc(S(=O)(=O)Cl)cc1.O=C(OO)c1cccc(Cl)c1.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(S(=O)(=O)OCC2Cc3c(C)c(Cl)cc(C(C)C)c3O2)cc1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)NC(C)c1ccc(Br)nc1.CCOc1ccc(OC2CNC2)cc1>>CCOc1ccc(OC2CN(c3ccc(C(C)NC(C)=O)cn3)C2)cc1",
        "output": "647"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)CCCN1C(=O)N=C(NC2CCCCC2)C12CCNCC2.Cl.Cl.O=Cc1cccc(I)c1>>COC(=O)CCCN1C(=O)N=C(NC2CCCCC2)C12CCN(Cc1cccc(I)c1)CC2",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)COc1cccc(CN)c1.CCN(CC)CC.O=Cc1ccc(-c2cccnc2)cc1>>CC(C)(C)OC(=O)COc1cccc(CNCc2ccc(-c3cccnc3)cc2)c1",
        "output": "683"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCC(NC2CCCCC2)CC1.CC(C)=O.Cc1ccc(S(=O)(=O)Cl)cc1.Cc1cccc([N+](=O)[O-])c1CO>>Cc1ccc(S(=O)(=O)OCc2c(C)cccc2[N+](=O)[O-])cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCCCCCCCCCCBr.CCOC(=O)c1ccc(O)cc1.CN(C)C=O.[H-].[Na+]>>CCOC(=O)c1ccc(OCCCCCCCCCCBr)cc1",
        "output": "385"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)CCc1ccc(-c2ccc(OC)cc2)n1-c1nc(C(N)=O)cs1.CO.[Li+].[OH-]>>COc1ccc(-c2ccc(CCC(=O)O)n2-c2nc(C(N)=O)cs2)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCS(=O)(=O)c1ccc(F)cc1.COC(=O)Cc1cc(O)c2cc(F)ccc2c1.O=C([O-])[O-].[K+].[K+]>>CCS(=O)(=O)c1ccc(Oc2cc(CC(=O)OC)cc3ccc(F)cc23)cc1",
        "output": "564"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCC(=O)Nc1nn(COCC[Si](C)(C)C)c2c(F)c(F)c(Br)cc12.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.O=C([O-])O.[F-].[Na+]>>CCCC(=O)Nc1n[nH]c2c(F)c(F)c(Br)cc12",
        "output": "813"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CN(c1ccccc1C(F)(F)F)C1CCNCC1.Cl.Cl.O.O=C(O)CNC(=O)c1ccc(Nc2ccccc2)cc1.On1nnc2ccccc21>>CN(c1ccccc1C(F)(F)F)C1CCN(C(=O)CNC(=O)c2ccc(Nc3ccccc3)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "N#Cc1ccc(CCCNC(=O)OCc2ccccc2)cc1F.[Pd]>>N#Cc1ccc(CCCN)cc1F",
        "output": "574"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC[C@@H]1CC[C@@H](CCc2ccccc2)CC1.Cc1ccccc1.O=C1CCC(=O)O1.S=C=S.[Al+3].[Cl-].[Cl-].[Cl-]>>CC[C@H]1CC[C@H](CCc2ccc(C(=O)CCC(=O)O)cc2)CC1",
        "output": "345"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCNC(=O)Oc1cn2ncnc(Oc3ccc([N+](=O)[O-])cc3F)c2c1C.CCO.[Cl-].[NH4+].[Zn]>>CCNC(=O)Oc1cn2ncnc(Oc3ccc(N)cc3F)c2c1C",
        "output": "335"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.O=C(CN1CC2CC(O)(c3ccccc3)CC2C1)c1ccccc1.[BH4-].[Na+]>>OC(CN1CC2CC(O)(c3ccccc3)CC2C1)c1ccccc1",
        "output": "24"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)[C@H](CNC(=O)c1cccs1)NC(=O)c1c(C)nc(NCCCc2cccc(O)c2)nc1C.O.O.[Li]O>>Cc1nc(NCCCc2cccc(O)c2)nc(C)c1C(=O)N[C@@H](CNC(=O)c1cccs1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.Fc1ccc2cc[nH]c2c1.[BH3-]C#N.[Na+].[Na+].[OH-]>>Fc1ccc2c(c1)NCC2",
        "output": "672"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O=C(NCC1Cc2ccccc2C1)OCc1ccccc1.[C].[Pd]>>NCC1Cc2ccccc2C1",
        "output": "574"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C1CCNC1.CO.COc1cc(CCc2cc(NC(=O)c3cnc(Cl)cn3)[nH]n2)cc(OC)c1.CS(C)=O>>COc1cc(CCc2cc(NC(=O)c3cnc(N4CCC(N(C)C)C4)cn3)[nH]n2)cc(OC)c1",
        "output": "505"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOc1cc2c(=O)[nH]cnc2cc1OC(C)C.Cl.O=P(Cl)(Cl)Cl>>CCOc1cc2c(Cl)ncnc2cc1OC(C)C",
        "output": "14"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(F)cc1F.ClC(Cl)Cl.O=S(=O)(O)Cl>>Cc1cc(S(=O)(=O)Cl)c(F)cc1F",
        "output": "357"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.O=[N+]([O-])c1cnn(Cc2cc(Cl)ccc2OCc2ccccc2)c1>>Nc1cnn(Cc2cc(Cl)ccc2OCc2ccccc2)c1",
        "output": "628"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CN.O=C1c2ccccc2C(=O)N1Cc1noc(-c2ncn3c2[C@@H]2CCN2C(=O)c2ccccc2-3)n1>>NCc1noc(-c2ncn3c2[C@@H]2CCN2C(=O)c2ccccc2-3)n1",
        "output": "242"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC(=O)[O-].Cc1nc2ccc(C=O)cc2o1.O.O=C1CSC(=Nc2c(Cl)cccc2Cl)N1.[Na+]>>Cc1nc2ccc(C=C3SC(=Nc4c(Cl)cccc4Cl)NC3=O)cc2o1",
        "output": "314"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1ccc(Cl)c(-c2nc3ccccc3[nH]2)c1.O=C(O)C1CCC(c2ccccc2)CC1>>O=C(Nc1ccc(Cl)c(-c2nc3ccccc3[nH]2)c1)C1CCC(c2ccccc2)CC1",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N.COC1=C(OC)C(=O)C(Cc2ccc(CCC(=O)O)cc2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(CCC(=O)NC(C)C)cc2)=C(C)C1=O",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC(C)=O.CNC(=O)C(C)(C)Oc1ccc(O)cc1.Fc1cccc(CBr)c1.O=C([O-])[O-].[K+].[K+]>>CNC(=O)C(C)(C)Oc1ccc(OCc2cccc(F)c2)cc1",
        "output": "127"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)c1cn2c3c(c(F)c(F)cc3c1=O)OCC21CC1.O.O=C([O-])[O-].[K+].[K+]>>O=C(O)c1cn2c3c(c(F)c(F)cc3c1=O)OCC21CC1",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOc1ccc([N+](=O)[O-])c(C=C(Br)Br)c1.CO.[Pt]>>CCOc1ccc(N)c(C=C(Br)Br)c1",
        "output": "202"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OCC1=C(C(=O)OC(C)(C)C)N2C(=O)[C@@H](N)[C@H]2SC1.CC(C)(C)OC(=O)NCc1ccc(CC(=O)O)s1.CC(C)COC(=O)Cl.CN1CCOCC1.ClCCl.O=P([O-])([O-])O.[K+].[K+]>>CC(=O)OCC1=C(C(=O)OC(C)(C)C)N2C(=O)[C@@H](NC(=O)Cc3ccc(CNC(=O)OC(C)(C)C)s3)[C@H]2SC1",
        "output": "133"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOCC.CC[SiH](CC)CC.CSc1ncncc1C1c2c(F)cccc2C(=O)C1(C)C.ClCCCl.FB(F)F.O=C([O-])[O-].[Na+].[Na+]>>CSc1ncncc1C1c2c(F)cccc2CC1(C)C",
        "output": "92"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc(NC(=O)OCC(Cl)(Cl)Cl)on1.Fc1cccc(-c2cccc(N3CCNCC3)c2)c1F>>Cc1cc(NC(=O)N2CCN(c3cccc(-c4cccc(F)c4F)c3)CC2)on1",
        "output": "980"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cccc(C)n1.ClCCl.Nc1ccn(CCCO)n1.O=C(Cl)[C@H](CC1CCCC1)c1ccc(Cl)c(Cl)c1>>O=C(Nc1ccn(CCCO)n1)[C@H](CC1CCCC1)c1ccc(Cl)c(Cl)c1",
        "output": "527"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)NS(=O)(=O)c1cccc(-c2cccc(-c3nc(-c4ccc(C(F)(F)F)cc4)cc(C(F)(F)F)n3)n2)c1.O=C(O)C(F)(F)F>>NS(=O)(=O)c1cccc(-c2cccc(-c3nc(-c4ccc(C(F)(F)F)cc4)cc(C(F)(F)F)n3)n2)c1",
        "output": "680"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(Cc1ccc(OCCc2sc(-c3ccccc3)nc2C)cc1C)OCC.[Li+].[OH-]>>CCOC(Cc1ccc(OCCc2sc(-c3ccccc3)nc2C)cc1C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.CC(=O)OCC(Cl)(Cl)Cl.CCC(=O)OCC(Cl)(Cl)Cl.COc1nc(N)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O.O.O=P([O-])([O-])[O-].OCC(Cl)(Cl)Cl.[K+].[K+].[K+].c1ccncc1>>COc1nc(N)nc2c1ncn2[C@@H]1O[C@H](COC(C)=O)[C@@H](O)[C@@H]1O",
        "output": "126"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Nc1cccc(-c2nnn[nH]2)c1.O=S(=O)(Cl)c1c(Cl)cc(Cl)cc1Cl>>O=S(=O)(Nc1cccc(-c2nnn[nH]2)c1)c1c(Cl)cc(Cl)cc1Cl",
        "output": "68"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)Cl.NCCCCn1cncc1-c1ccccc1.O=C([O-])O.[Na+]>>CC(=O)NCCCCn1cncc1-c1ccccc1",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCCS(N)(=O)=O.O=C(O)c1cc(C2CC2)c(OCC2CN(C(c3ccccc3)c3ccccc3)C2)cc1F>>COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CN(C(c3ccccc3)c3ccccc3)C2)cc1F",
        "output": "580"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)CCN.Nc1ccc(-c2nc(N3CCOCC3)c3ccn(CC(F)(F)F)c3n2)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CN(C)CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3ccn(CC(F)(F)F)c3n2)cc1",
        "output": "914"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1=COCCC1.OCCCCCCCBr>>BrCCCCCCCOC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C(C)(C)CCCCCC(c1ccccc1Cl)N1CCc2c(ccn2C(=O)OC(C)(C)C)C1.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)C(C)(C)CCCCCC(c1ccccc1Cl)N1CCc2[nH]ccc2C1",
        "output": "848"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN1Cc2nc3c(Br)cccc3c(N)c2C1=O.COc1ccc(B(O)O)c(OC)n1>>CCN1Cc2nc3c(-c4ccc(OC)nc4OC)cccc3c(N)c2C1=O",
        "output": "883"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC(OCc2ccccc2)C1CC(O)Cn1cnc2cccnc2c1=O.CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-]>>CC(C)(C)OC(=O)N1CCC(OCc2ccccc2)C1CC(=O)Cn1cnc2cccnc2c1=O",
        "output": "87"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1[nH]nnc1Nc1ccccc1.[Na+].[OH-]>>O=C(O)c1[nH]nnc1Nc1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COCCNCCN.Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(Cl)c2c1>>COCCNCCNc1cc(N2CCS(=O)(=O)c3ccccc3C2)nc2ccc(C)cc12",
        "output": "78"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cc1ncnc2c1c(NCCc1cccnc1)cc(=O)n2OCc1ccccc1.[C].[H][H].[OH-].[OH-].[Pd+2]>>Cc1ncnc2c1c(NCCc1cccnc1)cc(=O)n2O",
        "output": "630"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COCCN(Cc1cnc(-c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)n1C)C(=O)COC(C)=O.O.[Cl-].[Fe].[NH4+]>>COCCN(Cc1cnc(-c2cc3nccc(Oc4ccc(N)cc4F)c3s2)n1C)C(=O)COC(C)=O",
        "output": "335"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1cccc(C2CCN(CCCN)CC2)c1.O=C(O)C(c1ccccc1)(c1ccccc1)c1ccccc1>>CC(=O)Nc1cccc(C2CCN(CCCNC(=O)C(c3ccccc3)(c3ccccc3)c3ccccc3)CC2)c1",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOC(C)=O.O=[N+]([O-])c1ccc(F)c(F)c1.OC1CCNCC1>>O=[N+]([O-])c1ccc(N2CCC(O)CC2)c(F)c1",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#CC(I)OC(=O)Cc1ccc(OC(C)=O)cc1.C1COCCO1.CCCCN.CCOCC.Cl>>C#CC(I)OC(=O)Cc1ccc(O)cc1",
        "output": "22"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(N2CCC(N3CCN(C)CC3)CC2)c(Cl)cc1N.Clc1ncc(Cl)c(-c2c[nH]c3ccccc23)n1>>COc1cc(N2CCC(N3CCN(C)CC3)CC2)c(Cl)cc1Nc1ncc(Cl)c(-c2c[nH]c3ccccc23)n1",
        "output": "808"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COc1ccc(N(C)C)c(NC(C)=O)c1>>CCNc1cc(OC)ccc1N(C)C",
        "output": "112"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1ncc2c(cc(-c3ccccc3)c(=O)n2CCc2ccccc2)c1O.C[O-].NCCC(=O)O.[Na+]>>O=C(O)CCNC(=O)c1ncc2c(cc(-c3ccccc3)c(=O)n2CCc2ccccc2)c1O",
        "output": "487"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(c1nn2ccc(C(=O)O)c2c(=O)n1Cc1ccccc1)N(CCCNC(=O)OC(C)(C)C)C(=O)c1ccc(C)cc1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CNC.On1nnc2ccccc21>>CCC(c1nn2ccc(C(=O)N(C)C)c2c(=O)n1Cc1ccccc1)N(CCCNC(=O)OC(C)(C)C)C(=O)c1ccc(C)cc1",
        "output": "256"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(CC)(CC)CCO.CCN(CC)CC.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl>>CCC(CC)(CC)CC=O",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)Cl)cc1.CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(Br)cc32)cc1.FC(F)(F)c1ccc2c(n1)Nc1ccc(Br)cc1NC2.FC(F)(F)c1ccc2c(n1)Nc1ccc(I)cc1NC2.O=S(=O)(Cl)c1ccc(OC(F)(F)F)cc1>>O=S(=O)(c1ccc(OC(F)(F)F)cc1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccc(I)cc21",
        "output": "791"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.NCc1ccc(N)cc1.O.O=C([O-])O.O=[N+]([O-])c1ccc(F)c([N+](=O)[O-])c1.[Na+]>>Nc1ccc(CNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])cc1",
        "output": "764"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(=O)Cl.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-].c1ccc2c(c1)CCc1ccccc1-2>>CCC(=O)c1ccc2c(c1)CCc1ccccc1-2",
        "output": "31"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.CCOC(=O)N1c2ccc(OC)nc2[C@@H](N)C[C@H]1CC.O=C(OCc1ccccc1)c1cnc(Cl)cn1>>CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2cnc(C(=O)OCc3ccccc3)cn2)C[C@H]1CC",
        "output": "148"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br.N#Cc1cnccc1-c1cc(N)ccc1F.O.O=N[O-].[Cu]Br.[Na+]>>N#Cc1cnccc1-c1cc(Br)ccc1F",
        "output": "373"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN1CC[NH+](C)C1Cl.COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)O)c2)=C(C)C1=O.ClCCl.Nc1ccccc1[N+](=O)[O-].[Cl-]>>COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3ccccc3[N+](=O)[O-])c2)=C(C)C1=O",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.CC(C)O.CC(O)(CO)COc1cc(O)ccc1N>>CC(=O)Nc1ccc(O)cc1OCC(C)(O)CO",
        "output": "6"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3cncnc3)c2)cc1C(F)(F)F.ClCCl.O=C(O)C(F)(F)F>>CCCN(C)c1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3cncnc3)c1)=N2",
        "output": "930"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1c(C(F)(F)F)nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1N.O=S(=O)(O)O>>Nc1c(C(=O)O)c(C(F)(F)F)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCOC(=O)C(Nc1ccc(C#N)cc1)(c1cc(C)c(OC)c(C)c1)C(F)(F)F.CCOC(C)=O.CO.O.[Cl-].[NH3+]O>>CCOC(=O)C(Nc1ccc(C(=N)NO)cc1)(c1cc(C)c(OC)c(C)c1)C(F)(F)F",
        "output": "854"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCOC(=O)C(F)(F)C(O)c1ccccc1.Cl.ClCCl.O=C(Cl)C12CC3CC(CC(C3)C1)C2>>CCOC(=O)C(F)(F)C(OC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccc1",
        "output": "126"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC(COCc2ccccc2)(C(O)CO)CC1.CCO.[Pd]>>CC(C)(C)OC(=O)N1CCC(CO)(C(O)CO)CC1",
        "output": "178"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.C[Si](C)(C)CCOCn1c(O[C@@H]2CO[C@@H]3[C@H](O)CO[C@@H]32)cc2nc(-c3ccc(Br)cc3)c(Cl)cc21.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccccc1O.[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>C[Si](C)(C)CCOCn1c(O[C@@H]2CO[C@@H]3[C@H](O)CO[C@@H]32)cc2nc(-c3ccc(-c4ccccc4O)cc3)c(Cl)cc21",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OCCc1cc(Br)c(Oc2ccc(=O)n(C(C)C)n2)c(Br)c1.CO.[K+].[OH-]>>CC(C)n1nc(Oc2c(Br)cc(CCO)cc2Br)ccc1=O",
        "output": "225"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)N1CCNCC1.Fc1ccc(CCBr)cc1.O>>CCOC(=O)N1CCN(CCc2ccc(F)cc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)c1ccc([N+](=O)[O-])cc1Nc1ccc(F)cc1.CCOC(C)=O.CO.[C].[Pd]>>CC(C)(C)OC(=O)c1ccc(N)cc1Nc1ccc(F)cc1",
        "output": "772"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCc1ccc(CO)c2cc(C(F)(F)F)nn12.ClC(Cl)Cl.[Mn+4].[O-2].[O-2]>>COCc1ccc(C=O)c2cc(C(F)(F)F)nn12",
        "output": "520"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrP(Br)Br.C1CCOC1.O.O=C(O)c1cccc2c1Cc1ccccc1-2.OCc1cccc2c1Cc1ccccc1-2>>BrCc1cccc2c1Cc1ccccc1-2",
        "output": "300"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(O)c1.CN(C)C=O.CNc1cc(F)ccc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>CNc1cc(Oc2cccc(NC(=O)OC(C)(C)C)c2)ccc1[N+](=O)[O-]",
        "output": "564"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1Nc1nc(Nc2cncc(-c3cccc([N+](=O)[O-])c3)c2)c(C#N)cc1F.CO.O=C[O-].[NH4+].[Pd]>>CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1Nc1nc(Nc2cncc(-c3cccc(N)c3)c2)c(C#N)cc1F",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(Cc1c[nH]c2ccccc12)NC(=O)Oc1ccccc1.CN(C)C1(c2ccccc2)CCC(CN)CC1.[Na+].[OH-]>>CC(Cc1c[nH]c2ccccc12)NC(=O)NCC1CCC(c2ccccc2)(N(C)C)CC1",
        "output": "488"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)Cn1nc(-c2ccc(F)cc2F)cc(CO)c1=O.COC(=O)c1cc(-c2ccc(OC)c(F)c2)n[nH]c1=O.Fc1ccc(CCl)cc1>>COC(=O)c1cc(-c2ccc(OC)c(F)c2)nn(Cc2ccc(F)cc2)c1=O",
        "output": "842"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCCc1nc2ccc(C)cc2c(CO)c1Cc1ccc(Br)cc1.CCOC(C)=O.CN(C)c1ccncc1.ClCCl.ClCCl>>CCCc1nc2ccc(C)cc2c(CO[Si](C)(C)C(C)(C)C)c1Cc1ccc(Br)cc1",
        "output": "193"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Nc1cc(F)c(Cl)cc1Br.O.O=N[O-].O=S(=O)(O)O.[I-].[K+].[Na+]>>Fc1cc(I)c(Br)cc1Cl",
        "output": "200"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.NN.Nc1nc2ccccc2c2c1nc(CN1C(=O)c3ccccc3C1=O)n2CC1(O)CCC1>>NCc1nc2c(N)nc3ccccc3c2n1CC1(O)CCC1",
        "output": "242"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.OCC[C@H]1CCc2sc3ncnc(OC4CCC(N5CCOCC5)CC4)c3c21>>O=CC[C@H]1CCc2sc3ncnc(OC4CCC(N5CCOCC5)CC4)c3c21",
        "output": "142"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.NS(=O)(=O)c1cc2cc(CCBr)ccc2s1.O.[N-]=[N+]=[N-].[Na+]>>[N-]=[N+]=NCCc1ccc2sc(S(N)(=O)=O)cc2c1",
        "output": "622"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NCCN.CCN(C(C)C)C(C)C.CN(C)C=O.ClCCCl.O=C(O)C=Cc1cc2ccc(O)cc2oc1=O.Oc1cccc2[nH]nnc12>>CC(C)(C)OC(=O)NCCNC(=O)C=Cc1cc2ccc(O)cc2oc1=O",
        "output": "549"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN1CCCC1=O.ClCCl.O=C(O)c1ccc(-n2cccn2)c(Cl)c1.O=S(Cl)Cl>>O=C(Cl)c1ccc(-n2cccn2)c(Cl)c1",
        "output": "3"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CI.O=C1CC(c2ccccc2)c2ccccc2N1.O=C1CC(c2ccccc2)c2ccccc2N1.[H-].[Na+]>>CN1C(=O)CC(c2ccccc2)c2ccccc21",
        "output": "237"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(O)cc1.ClCCCCBr>>COc1ccc(OCCCCCl)cc1",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.Cn1c(=O)n(C2CCNCC2)c2cccnc21.N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c1nnc2C1(C(F)(F)F)CC1.O=C(n1ccnc1)n1ccnc1>>Cn1c(=O)n(C2CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)Cn4c3nnc4C3(C(F)(F)F)CC3)CC2)c2cccnc21",
        "output": "734"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1c(-c2ccccc2OC)nnn1C.[Na+].[OH-]>>COc1ccccc1-c1nnn(C)c1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)Cn1c(C)c(Sc2ccccc2)c2c1CC(C)(C)CC2=O.CCOC(C)=O.ClCCl.O=S(=O)(O)Cl>>CCOC(=O)Cn1c(C)c(Sc2ccc(S(=O)(=O)Cl)cc2)c2c1CC(C)(C)CC2=O",
        "output": "357"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O.O=C1CC(c2cccc(C#Cc3ccc(OC(F)F)cc3)c2)C1.[BH4-].[Na+]>>OC1CC(c2cccc(C#Cc3ccc(OC(F)F)cc3)c2)C1",
        "output": "91"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Cl.ClCCl.N#Cc1ccc(CN)cc1>>CC(C)(C)OC(=O)NCc1ccc(C#N)cc1",
        "output": "686"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)C(C)c1cn(C)c2c(F)cc(Br)c(OC)c12.Cl.O.[K+].[OH-]>>COc1c(Br)cc(F)c2c1c(C(C)C(=O)O)cn2C",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCI.O=Cc1ccc(-c2ccc(F)cc2O)c(C2CC2)c1>>CCOc1cc(F)ccc1-c1ccc(C=O)cc1C1CC1",
        "output": "198"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)P(c1ccc2ccccc2c1-c1cccc2ccccc12)C(C)(C)C.COc1ccc2c(Cl)c(F)cnc2c1.CS(C)=O.Cc1ccccc1.ClCCl.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].Oc1ccc(Nc2nnc(-c3ccc(C(F)(F)F)cc3)c3ccccc23)cc1.[Cs+].[Cs+].[Pd].[Pd]>>COc1ccc2c(Oc3ccc(Nc4nnc(-c5ccc(C(F)(F)F)cc5)c5ccccc45)cc3)c(F)cnc2c1",
        "output": "351"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCCCC.Cc1cc(Br)c(C)c2c1SCCC21SCCS1.O=C=O.[Li]CCCC>>Cc1cc(C(=O)O)c(C)c2c1SCCC21SCCS1",
        "output": "654"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cccc(C)c1Cl.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>Cc1cccc(CBr)c1Cl",
        "output": "29"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cccc(C(=O)Cl)c1OC.Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1.O=C1CC(=O)N(c2ccc(NC(=O)c3ccccc3)cc2)c2ccc3ccccc3c2N1>>COc1cccc(C(=O)Nc2ccc(N3C(=O)CC(=O)Nc4c3ccc3ccccc43)cc2)c1OC",
        "output": "11"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.COCCOCCC(Br)C(=O)O.Cc1csc(N)n1.ClCCl.O.O=S(Cl)Cl>>COCCOCCC(Br)C(=O)Nc1nc(C)cs1",
        "output": "681"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1cc(N2CCC(N3CCCC3C)C2)ccc1N.O=C(O)c1ccc(N2CCCC2=O)cc1>>Cc1cc(N2CCC(N3CCCC3C)C2)ccc1NC(=O)c1ccc(N2CCCC2=O)cc1",
        "output": "50"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.NCc1ccc(-c2ccc(-c3c(-c4ccccc4)c(=O)n(OCc4ccccc4)c4ncc(F)cc34)cc2)cc1.O>>NCc1ccc(-c2ccc(-c3c(-c4ccccc4)c(=O)n(O)c4ncc(F)cc34)cc2)cc1",
        "output": "630"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Clc1ccccc1Br.O=C1N(c2ccc(OC(F)(F)F)cc2)CCC12CCNCC2>>O=C1N(c2ccc(OC(F)(F)F)cc2)CCC12CCN(c1ccccc1Cl)CC2",
        "output": "294"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC(CC)n1c(C=O)cc2cnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)nc21.CO.[BH4-].[Na+]>>CCC(CC)n1c(CO)cc2cnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)nc21",
        "output": "745"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cccc(C2(O)CCCNC2)c1.O=C(Cl)c1cccc(Br)c1>>COc1cccc(C2(O)CCCN(C(=O)c3cccc(Br)c3)C2)c1",
        "output": "201"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCn1c(=O)c2ncn(C)c2c2ccccc21.O=S(=O)(O)O.O=[N+]([O-])O>>CCCCn1c(=O)c2ncn(C)c2c2cc([N+](=O)[O-])ccc21",
        "output": "21"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CCOc1ncc(B2OC(C)(C)C(C)(C)O2)cc1C#N.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(Nc1cnccn1)N1c2nc(Cl)ccc2N2CC[C@H]1C2.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>CCOc1ncc(-c2ccc3c(n2)N(C(=O)Nc2cnccn2)[C@H]2CCN3C2)cc1C#N",
        "output": "968"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Brc1ccccc1.CC(C)(C)O[Na].CC(C)(C)P(C(C)(C)C)C(C)(C)C.Cc1ccccc1.Nc1ccccc1-c1ccccc1>>c1ccc(Nc2ccccc2-c2ccccc2)cc1",
        "output": "405"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=C(C)[C@@H]1CC[C@]2(N)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC[C@](CF)(C(=O)OCc7ccccc7)CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].ClCCCl.O=C([O-])O.O=CCC1(O)CCS(=O)(=O)CC1.[Na+].[Na+].[Ti+4]>>C=C(C)[C@@H]1CC[C@]2(NCCC3(O)CCS(=O)(=O)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC[C@](CF)(C(=O)OCc7ccccc7)CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12",
        "output": "426"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCO.CCOC(=O)C(C)c1ccc2c(c1)OCC(=O)N2.O.[Na+].[OH-]>>CC(C(=O)O)c1ccc2c(c1)OCC(=O)N2",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.CC#N.CCCCc1nc(NCc2ccc(OC)c(OC)c2)c2[nH]nc(C#CCCCCCl)c2n1.CCN(CC)CC>>CCCCc1nc(NCc2ccc(OC)c(OC)c2)c2[nH]nc(C#CCCCCN3CCCC3)c2n1",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1C(Nc2nc3ccccc3o2)CCCN1C(=O)OC(C)(C)C.Cc1cc(C)nc(NC2CCCN(C(=O)OC(C)(C)C)C2C)n1>>CC1NCCCC1Nc1nc2ccccc2o1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)[C@H]1CC2(CC2)CN[C@@H]1C(=O)O.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+].c1ccc(N2CCNCC2)cc1>>CC(C)(C)OC(=O)[C@H]1CC2(CC2)CN[C@@H]1C(=O)N1CCN(c2ccccc2)CC1",
        "output": "685"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.O=CCCCC1CC(c2ccccc2)=NO1.[Na+].c1ccc(N2CCNCC2)cc1>>c1ccc(C2=NOC(CCCCN3CCN(c4ccccc4)CC3)C2)cc1",
        "output": "484"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N(C)C.CN(C)c1ccc([N+](=O)[O-])c(C(=O)O)c1.CO.[H][H].[Ni]>>CN(C)c1ccc(N)c(C(=O)O)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3sc(C(=O)O)c(-c4ccccc4)c3c2)cc1.CC(N)CO>>CC(CO)NC(=O)c1sc2ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)cc2c1-c1ccccc1",
        "output": "736"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)Cl.ClCCl.Nc1cc(F)c(I)cc1F.c1ccncc1>>CS(=O)(=O)Nc1cc(F)c(I)cc1F",
        "output": "194"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CN1CCC[C@@H]1Cc1c[nH]c2ccccc12.C[Si](C)(C)[N-][Si](C)(C)C.O=S(=O)(Cl)c1ccccc1.[Na+]>>CN1CCC[C@@H]1Cc1cn(S(=O)(=O)c2ccccc2)c2ccccc12",
        "output": "648"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CN(C(=O)OCc1ccccc1)[C@@H](CCC(=O)N1CCN(C(=O)OC(C)(C)C)CC1)CO[Si](C)(C)C(C)(C)C.[Pd]>>CN[C@@H](CCC(=O)N1CCN(C(=O)OC(C)(C)C)CC1)CO[Si](C)(C)C(C)(C)C",
        "output": "428"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCCC[N+](CCCC)(CCCC)CCCC.O.O=C([O-])[O-].O=C1CCc2c(Br)cccc21.OB(O)c1ccc(F)cc1.[Br-].[K+].[K+].[Pd+2]>>O=C1CCc2c1cccc2-c1ccc(F)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CC(O)(COS(C)(=O)=O)c1cnc(N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)cn1.CCN(C(C)C)C(C)C.CNC>>CN(C)CC(C)(O)c1cnc(N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)cn1",
        "output": "496"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)[O-].CC(=O)[O-].O.O=C(O)c1cc(Br)cc2ccccc12.O=C([O-])O.OB(O)c1cccc(Cl)c1.[Na+].[Na+].[OH-].[Pd+2]>>O=C(O)c1cc(-c2cccc(Cl)c2)cc2ccccc12",
        "output": "837"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCSc1ccc([N+](=O)[O-])c(N)c1.O.[Fe].c1ccccc1>>C=CCSc1ccc(N)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)CS(=O)(=O)Cl.CCN(CC)CC.COC(=O)c1ccc2c(c1)[C@H](N)CC2.ClCCl>>COC(=O)c1ccc2c(c1)[C@H](NS(=O)(=O)CC(C)C)CC2",
        "output": "742"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cc1ccc(O)cc1.NCC(O)c1cccc(Cl)c1.O.c1ccccc1>>CC(Cc1ccc(O)cc1)NCC(O)c1cccc(Cl)c1",
        "output": "236"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C(NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1)OCc1ccccc1.[Pd]>>NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1",
        "output": "574"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cl.O=C([O-])O.O=C1CCCc2ccc(OCCCCOC3CCCCO3)nc2N1.[Na+]>>O=C1CCCc2ccc(OCCCCO)nc2N1",
        "output": "543"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.Cc1ccc(OS(=O)(=O)c2ccc([N+](=O)[O-])cc2)cc1.O.[Cl-].[Fe].[NH4+]>>Cc1ccc(OS(=O)(=O)c2ccc(N)cc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(C)=O.COC(=O)c1ccc2c(c1)CC(Nc1ccnc(Cl)c1)CC2.[Pd]>>COC(=O)c1ccc2c(c1)CC(Nc1ccncc1)CC2",
        "output": "40"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCC1CC1.O=C1C(=O)c2ccccc2C2=C1SCC1(CCNCC1)O2>>O=C1C(=O)c2ccccc2C2=C1SCC1(CCN(CC3CC3)CC1)O2",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCBr.CC(C)=O.CNCCC1(c2cccc(OC)c2)C=CCCC1.O=C([O-])[O-].[K+].[K+]>>C=CCN(C)CCC1(c2cccc(OC)c2)C=CCCC1",
        "output": "252"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COc1ccc(C(=O)CN2CCCC2c2cccc(OCCCN3CCCCC3)c2)cc1.ClCCl.[BH4-].[Na+]>>COc1ccc(C(O)CN2CCCC2c2cccc(OCCCN3CCCCC3)c2)cc1",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "N.N.N#C[C@@H]1CC[C@@H](C(=O)O)CC1.O.[Co].[H][H]>>NC[C@@H]1CC[C@@H](C(=O)O)CC1",
        "output": "246"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CCN(C(C)C)C(C)C.CN1CCCC1=O.O.O=[N+]([O-])c1cc(Br)cnc1Cl>>CC(C)(C)OC(=O)N1CCC(Nc2ncc(Br)cc2[N+](=O)[O-])CC1",
        "output": "70"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1C(=O)COc2nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3cccs3)cc21.ClCCl.O=C(O)C(F)(F)F>>CN1C(=O)COc2nc(-c3ccc(C4(N)CCC4)cc3)c(-c3cccs3)cc21",
        "output": "793"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Brc1ccc2ncc(N3CCOCC3)nc2c1.C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.[K+]>>CC1(C)OB(c2ccc3ncc(N4CCOCC4)nc3c2)OC1(C)C",
        "output": "934"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.CSC.Cl.O=C(O)c1cc(Br)c(F)cc1F>>OCc1cc(Br)c(F)cc1F",
        "output": "72"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)c1ccncc1.COC(=O)CCCCCCC(=O)c1cc(C)ccc1O.COc1cc2nccc(Cl)c2cc1OC.Clc1ccccc1Cl>>COC(=O)CCCCCCC(=O)c1cc(C)ccc1Oc1ccnc2cc(OC)c(OC)cc12",
        "output": "351"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Nc1ccc(Cl)cc1Oc1ccc(-c2noc(C)n2)cc1Cl.CCO.Cl>>Cc1nc(-c2ccc(Oc3cc(Cl)ccc3N)c(Cl)c2)no1",
        "output": "66"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=C(C)C(=O)Cl.CCN(CC)CC.CCOC(C)=O.CN1CCCC1=O.NCCc1ccc(O)cc1>>C=C(C)C(=O)NCCc1ccc(O)cc1",
        "output": "298"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(F)c(C(=O)O)c1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NC1CCCC1.O>>CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(F)c(C(=O)NC2CCCC2)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1=CCN(C2CCNCC2)CC1.CCN(C(C)C)C(C)C.CN(C)C=O.Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)O)cc2cn[nH]c12.ClCCl.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCC(N3CC=CCC3)CC2)cc2cn[nH]c12",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O=S(=O)(c1ccccc1)c1ccc2[nH]c3c(c2c1)CCN(Cc1ccccc1)CC3.[OH-].[OH-].[Pd+2]>>O=S(=O)(c1ccccc1)c1ccc2[nH]c3c(c2c1)CCNCC3",
        "output": "84"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(=O)c1ccc(C=CC(=O)O)cc1.Cl.NCCO.O=S(Cl)Cl.c1ccccc1>>CC(=O)c1ccc(C=CC(=O)NCCO)cc1",
        "output": "549"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(C#N)(C(F)(F)c2ccc(F)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>N#CC1(C(F)(F)c2ccc(F)cc2)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C([O-])O.O=P(Cl)(Cl)Cl.Oc1ccnc2ccc(C(F)(F)F)cc12.[Na+]>>FC(F)(F)c1ccc2nccc(Cl)c2c1",
        "output": "177"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1cc(Cn2cc([N+](=O)[O-])cn2)ccn1.CCO.N#N.O.[Cl-].[Fe].[NH4+]>>CC(=O)c1cc(Cn2cc(N)cn2)ccn1",
        "output": "628"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CCC[C@@H](NC(=O)N1CC(=NO)NC[C@H](Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(=O)O)c([N+](=O)[O-])c1.Cl.[Zn]>>CCC[C@@H](NC(=O)N1CC(=NO)NC[C@H](Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(=O)O)c(N)c1",
        "output": "71"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O.O=C(O)CCCCc1ccccc1.O=S(=O)(O)O>>COC(=O)CCCCc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)=O.CCN(CC)CC.CCO.Cc1ccc(S(=O)(=O)O)cc1.N#N.NC(=O)c1ccccc1.O=P(Cl)(Cl)Cl.O=c1[nH]ccc2ccccc12.[Cu].[Pd].c1ccccc1>>Clc1nccc2ccccc12",
        "output": "100"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NC(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(Cl)nc1.O=C(O)C(F)(F)F>>NC(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(Cl)nc1",
        "output": "538"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CO.O=C(Cl)c1ccccc1.O=C(O)C(F)(F)F.O=C1N(C2CCCCC2)CCC12CCNCC2>>O=C(c1ccccc1)N1CCC2(CC1)CCN(C1CCCCC1)C2=O",
        "output": "201"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N1CC2CC(C1)c1cc(N)c(N)cc12.CCO>>Cc1nc2cc3c(cc2[nH]1)C1CC3CN(C(=O)OC(C)(C)C)C1",
        "output": "512"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(=O)O.CCO.Cc1ccc(S(=O)(=O)O)cc1.NC(=O)[C@H](CCC(=O)O)NC(=O)OCc1ccccc1.O.[H][H]>>CCOC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(N)=O",
        "output": "47"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)NC(C)C.CO.COc1cc(C(C)=O)ccc1OCCCCl.Fc1ccc2c(C3CCNCC3)noc2c1>>COc1cc(C(C)=O)ccc1OCCCN1CCC(c2noc3cc(F)ccc23)CC1",
        "output": "138"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>Cc1ccc(S(=O)(=O)O[C@H]2CC[C@@]3(C)C(=CC[C@H]4[C@@H]5CC[C@H]([C@H](C)CCCC(C)C)[C@@]5(C)CC[C@@H]43)C2)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CSc1nccc(-c2oc(C3CC3)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1.ClCCl.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nccc(-c2oc(C3CC3)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1",
        "output": "595"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)c1ccc(C=O)cc1.CO.Cl.Cl.NCCc1cccc(C(F)(F)F)c1F.O=C([O-])[O-].[BH4-].[K+].[K+].[Na+]>>CC(C)(C)c1ccc(CNCCc2cccc(C(F)(F)F)c2F)cc1",
        "output": "468"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(F)cc2c1NC(c1cccc(N3CCN(c4ccc(C)cc4)CC3)c1)CC2(C)C.Cl.O.[Na+].[OH-]>>Cc1ccc(N2CCN(c3cccc(C4CC(C)(C)c5cc(F)cc(C(=O)O)c5N4)c3)CC2)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrBr.CS(=O)(=O)c1ccc(CN)cc1.CS(=O)(=O)c1ccc(CN)nc1.Cc1c(Br)c(=O)c(C(=O)O)cn1C(C)C.Cc1c(Br)c(=O)c(C(=O)O)cn1C1CCC1.Cl>>Cc1c(Br)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=O)cn2)cn1C1CCC1",
        "output": "674"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)CS(=O)(=O)Cl.CCN(CC)CC.COC[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(CN)nc32)[C@H](O)[C@@H]1O>>COC[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(CNS(=O)(=O)CC(C)C)nc32)[C@H](O)[C@@H]1O",
        "output": "493"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)N1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1.CI.CN(C)P(=O)(N(C)C)N(C)C.[H-].[Na+]>>CCOC(=O)N1CCC(n2c(=O)n(C)c3cc(Cl)ccc32)CC1",
        "output": "404"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)C1=CC2(CCC1S(=O)(=O)Nc1ccc(F)cc1Cl)OCCO2.Cl.O.[Li+].[OH-]>>O=C(O)C1=CC2(CCC1S(=O)(=O)Nc1ccc(F)cc1Cl)OCCO2",
        "output": "122"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)C(C)c1ccc(N(C)c2ccc(OCc3ccccc3)cc2)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(CO)c1ccc(N(C)c2ccc(OCc3ccccc3)cc2)cc1",
        "output": "343"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCc1c(C(=O)O)c2ccc(OC)cc2n1C.CN.O=S(Cl)Cl>>CCc1c(C(=O)NC)c2ccc(OC)cc2n1C",
        "output": "674"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)CC(=O)Cl.CCN(CC)CC.ClCCl.c1ccc(C2CNCCO2)cc1>>CC(C)CC(=O)N1CCOC(c2ccccc2)C1",
        "output": "125"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.CCN(CC)CC.O=[N+]([O-])c1ccc(Cl)c(S(=O)(=O)Cl)c1Cl>>O=[N+]([O-])c1ccc(Cl)c(S(=O)(=O)N2CCOCC2)c1Cl",
        "output": "99"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1nc(-c2sc(N)nc2-c2ccccc2)no1.O=C(Cl)C1CCCCC1>>Cc1nc(-c2sc(NC(=O)C3CCCCC3)nc2-c2ccccc2)no1",
        "output": "553"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)n1ccc(N)n1.CN1CCOc2c(ccc(Oc3cc(O[C@H]4CCOC4)cc(C(=O)O)c3)c2Cl)C1=O.ClCCl.c1ccncc1>>CN1CCOc2c(ccc(Oc3cc(O[C@H]4CCOC4)cc(C(=O)Nc4ccn(C(=O)OC(C)(C)C)n4)c3)c2Cl)C1=O",
        "output": "917"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC(=O)O)S(=O)(=O)c1ccc(F)cc1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.NCc1cccc(-c2ccc(C(F)(F)F)cn2)c1.O=S(=O)([O-])O.[K+]>>CCN(CC(=O)NCc1cccc(-c2ccc(C(F)(F)F)cn2)c1)S(=O)(=O)c1ccc(F)cc1",
        "output": "599"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.C[Si](C)(C)C=[N+]=[N-].O=C(O)c1cc(Br)c(F)c(F)c1Nc1ccccc1Cl>>COC(=O)c1cc(Br)c(F)c(F)c1Nc1ccccc1Cl",
        "output": "195"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCC(=O)Cl.CCN(CC)CC.ClCCCNCCc1ccccc1.ClCCl>>CCCCC(=O)N(CCCCl)CCc1ccccc1",
        "output": "125"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CCOC(C)=O.CN1CCNCC1.COC(=O)c1sc(-n2cnc3ccc(C=O)cc32)cc1O[C@H](C)c1ccccc1C(F)(F)F.O.O=C([O-])[O-].[K+].[K+].[Na+]>>COC(=O)c1sc(-n2cnc3ccc(CN4CCN(C)CC4)cc32)cc1O[C@H](C)c1ccccc1C(F)(F)F",
        "output": "567"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOc1cc(COC(C)=O)ncc1C.[Na+].[OH-]>>CCOc1cc(CO)ncc1C",
        "output": "348"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(C)(C)C.COC(C)(C)C.COc1nc(C)cc(C)c1C#N.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1nc(C)cc(C)c1CN",
        "output": "560"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=C(O)c1ccc(Sc2ccccc2C(=O)O)c([N+](=O)[O-])c1.O=[Pt]=O.[Pd]>>Nc1cc(C(=O)O)ccc1Sc1ccccc1C(=O)O",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCO.ClCCl.II.c1c[nH]cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)NCCI",
        "output": "670"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(-c2nc(C(=O)O)n(C)c2-c2ccc(C)cc2)cc1.NC1CCCCC1>>Cc1ccc(-c2nc(C(=O)NC3CCCCC3)n(C)c2-c2ccc(C)cc2)cc1",
        "output": "951"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CI.CN(C)C=O.Cl.O=C(O)c1cc2cc(C(F)(F)F)ccc2o1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cc2cc(C(F)(F)F)ccc2o1",
        "output": "415"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCc1ccc2ncccc2c1>>CS(=O)(=O)OCc1ccc2ncccc2c1",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCC(CC)(c1ccc(OCC(=O)C(C)(C)C)c(C)c1)c1cc2cc(C(=O)NC(C)(C)C(=O)O)ccc2o1.[BH4-].[Na+]>>CCC(CC)(c1ccc(OCC(O)C(C)(C)C)c(C)c1)c1cc2cc(C(=O)NC(C)(C)C(=O)O)ccc2o1",
        "output": "91"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCCl.ClCCl.F[P-](F)(F)(F)(F)F.N#CC=Cc1ccc2c(c1)CCCC2N.O=C(O)CC(NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1>>N#CC=Cc1ccc2c(c1)CCCC2NC(=O)CC(NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1",
        "output": "599"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)Oc2cc(CC(=O)O)cc(O)c2[C@@H]2CC(=O)CC[C@H]21.CCCCBr.CN(C)C=O.O=C([O-])O.[Na+]>>CCCCOC(=O)Cc1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(=O)C[C@@H]21",
        "output": "416"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Nc1cc(Br)cnc1N.O=C(Cl)CCCBr.c1ccncc1>>Nc1ncc(Br)cc1NC(=O)CCCBr",
        "output": "422"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCC(CN)(c2cccc(-c3ccccc3)c2)CC1.O=C(O)c1cncc(-c2noc(C(F)(F)F)n2)c1>>CN1CCC(CNC(=O)c2cncc(-c3noc(C(F)(F)F)n3)c2)(c2cccc(-c3ccccc3)c2)CC1",
        "output": "674"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cc1n[nH]c2ccccc12.N#Cc1ccccc1F.O=C([O-])[O-].[Cl-].[Cs+].[Cs+].[NH4+]>>Cc1nn(-c2ccccc2C#N)c2ccccc12",
        "output": "751"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CNCCN1.COc1cccc(Cl)n1.O.O=C([O-])[O-].[K+].[K+]>>COc1cccc(N2CCNCC2)n1",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "B.C1CCOC1.CCn1c(=O)c2cc(NC(=O)CC(C)CC(=O)O)ccc2n(CC)c1=O.CSC.O>>CCn1c(=O)c2cc(NC(=O)CC(C)CCO)ccc2n(CC)c1=O",
        "output": "231"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCNCCO.CS(=O)(=O)OCCCCc1ccc2c(-c3ccc(Cl)cc3)nsc2c1>>CCN(CCO)CCCCc1ccc2c(-c3ccc(Cl)cc3)nsc2c1",
        "output": "496"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.CCCc1c(CC)c(=O)on1C(=O)Cl.ClCCl>>CCCc1c(CC)c(=O)on1C(=O)N1CCCC1",
        "output": "258"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COc1ccc(C(C)(C)CC(O)(C(=O)Nc2ccc3c(c2)COC3=O)C(F)(F)F)cc1.O=C1CCC(=O)N1Cl>>COc1ccc(C(C)(C)CC(O)(C(=O)Nc2ccc3c(c2)COC3=O)C(F)(F)F)cc1Cl",
        "output": "121"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.C1COCCO1.CS(=O)(=O)OCCC1OC(=C2C(=O)Nc3ccccc32)c2ccccc21>>O=C1Nc2ccccc2C1=C1OC(CCN2CCOCC2)c2ccccc21",
        "output": "496"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.Fc1ccc(F)c(C(Sc2ccc(Cl)cc2)c2cc(Cl)ncc2Cl)c1.NCCO>>OCCNc1cc(C(Sc2ccc(Cl)cc2)c2cc(F)ccc2F)c(Cl)cn1",
        "output": "70"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.Clc1ccc2c(c1)CNCc1nnc(N3CCC(c4ccccn4)CC3)n1-2.O=C([O-])O.[Na+].[Na+]>>CN1Cc2cc(Cl)ccc2-n2c(nnc2N2CCC(c3ccccn3)CC2)C1",
        "output": "69"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc(N)ccc1N1CCN(C)CC1.Cc1c(S(=O)(=O)Cl)sc2ccc(Cl)cc12.ClCCl>>COc1cc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)ccc1N1CCN(C)CC1",
        "output": "861"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.CCOC(=O)CCc1ccc(O)c(OCc2ccccc2)c1.CCOc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CCOC(=O)CCc1ccc(OCCCc2cn(-c3ccc(C(F)(F)F)cn3)nc2OCC)c(OCc2ccccc2)c1",
        "output": "478"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.Cl.ClC(Cl)Cl.ClCCl.ClCc1ccccc1.O[C@@H]1CCNC1.[Na+].[OH-]>>O[C@@H]1CCN(Cc2ccccc2)C1",
        "output": "156"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1c(C(N)=O)n(C)c2c(Br)cc(Cl)cc12.OB(O)c1ccc(Cl)cc1Cl>>Cc1c(C(N)=O)n(C)c2c(-c3ccc(Cl)cc3Cl)cc(Cl)cc12",
        "output": "833"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCCCC1.CCOc1nc2cc([N+](=O)[O-])ccc2c(=O)o1.[Pd].c1ccccc1>>CCOc1nc2cc(N)ccc2c(=O)o1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)c1ccc(OCCNC(=O)c2ccc(C(C)C)cc2)cc1.O.[Na+].[OH-]>>CC(C)c1ccc(C(=O)NCCOc2ccc(C(=O)O)cc2)cc1",
        "output": "222"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC.CCCCCCCCCCCCC[C@@H](CC(N)=O)OC(=O)[C@H](CCCC(=O)O)NC(=O)c1cnc2ccccc2c1.CO.C[Si](C)(C)C=[N+]=[N-]>>CCCCCCCCCCCCC[C@@H](CC(N)=O)OC(=O)[C@H](CCCC(=O)OC)NC(=O)c1cnc2ccccc2c1",
        "output": "195"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.CO.Cc1ccc(S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCCNC(=N)NS(=O)(=O)c2ccc(C)cc2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)OCc2ccccc2Cl)C(=O)OCc2ccccc2)cc1.ClC(Cl)Cl.[Na+].[OH-]>>Cc1ccc(S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCCNC(=N)NS(=O)(=O)c2ccc(C)cc2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)OCc2ccccc2Cl)C(=O)O)cc1",
        "output": "186"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.OCc1ccn(-c2ccc(C(F)(F)F)cc2)n1>>O=Cc1ccn(-c2ccc(C(F)(F)F)cc2)n1",
        "output": "573"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CN1CCC(Sc2cn(C)c3ccc(Br)cc23)CC1.O=C=O.[Li]CCCC>>CN1CCC(Sc2cn(C)c3ccc(C(=O)O)cc23)CC1",
        "output": "654"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Br.CC(=O)O.CC(=O)O.CCOC(C)=O.CNC(=O)c1cccc2cc(Oc3ccnc4cc(OCC5(NC(=O)OCc6ccccc6)CC5)c(OC)cc34)ccc12.O.O=C([O-])[O-].[Na+].[Na+]>>CNC(=O)c1cccc2cc(Oc3ccnc4cc(OCC5(N)CC5)c(OC)cc34)ccc12",
        "output": "574"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COC(=O)Cl.N#CCc1c[nH]c2ccc(N)cc12>>COC(=O)Nc1ccc2[nH]cc(CC#N)c2c1",
        "output": "102"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)O)CC2)nc1C.NS(=O)(=O)Cc1ccccc1F>>CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccccc3F)CC2)nc1C",
        "output": "644"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@](C)(O)CO.CN(C)c1ccncc1.ClCCl.O=C(CCCCCS(=O)(=O)Cl)OCc1ccccc1.c1ccncc1>>CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@](C)(O)COS(=O)(=O)CCCCCC(=O)OCc1ccccc1",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.Cl.O.O=[N+]([O-])c1cccc(S(F)(F)(F)(F)F)c1>>Nc1cccc(S(F)(F)(F)(F)F)c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NC1CCN(C2CC2)CC1.O=C1c2ccccc2C(=O)N1CCS(=O)(=O)Cl>>O=C1c2ccccc2C(=O)N1CCS(=O)(=O)NC1CCN(C2CC2)CC1",
        "output": "493"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.ClCCl.O=[N+]([O-])c1ccc(OCCCCCCCCBr)cc1.[H][H].[Pd]>>Nc1ccc(OCCCCCCCCBr)cc1",
        "output": "202"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CNCCC#Cc1ccccn1.COc1cccc(OC)c1C(=O)Cl.ClC(Cl)Cl>>COc1cccc(OC)c1C(=O)N(C)CCC#Cc1ccccn1",
        "output": "201"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=[N+]=[N-].CC(=O)N[C@@H](CS)C(=O)O.CCOCC>>COC(=O)[C@H](CS)NC(C)=O",
        "output": "60"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1cncc2c(Nc3ccc([Si](C)(C)C)cc3F)c(C(=O)OCc3ccccc3)oc12.CCOC(C)=O.[Pd]>>CCOC(=O)c1cncc2c(Nc3ccc([Si](C)(C)C)cc3F)c(C(=O)O)oc12",
        "output": "291"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.COC(C)n1cc(C2=C(c3cn(C)c4cc([N+](=O)[O-])ccc34)C(=O)NC2=O)c2ccccc21.Cl.O.[Cl-].[Na+]>>CC(O)n1cc(C2=C(c3cn(C)c4cc([N+](=O)[O-])ccc34)C(=O)NC2=O)c2ccccc21",
        "output": "423"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(C)c1=O.CCOP(=O)(CCCN)OCC.O=C(O)C(=O)O>>CCOP(=O)(CCCNC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(C)c1=O)OCC",
        "output": "498"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Nc1cc(C(C)(C)C)c(Cl)cc1CBr.CNC1CCCCC1.ClC(Cl)(Cl)Cl>>CC(=O)Nc1cc(C(C)(C)C)c(Cl)cc1CN(C)C1CCCCC1",
        "output": "248"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CN(C)C=O.COC(=O)CBr.NC(=O)c1cccc2c1c1c(O)cccc1n2Cc1cccc(C(F)(F)F)c1>>COC(=O)COc1cccc2c1c1c(C(N)=O)cccc1n2Cc1cccc(C(F)(F)F)c1",
        "output": "557"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COc1cc(N(C)CCN2CCN(C)CC2)c([N+](=O)[O-])cc1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1.O.[Cl-].[Fe].[NH4+]>>COc1cc(N(C)CCN2CCN(C)CC2)c(N)cc1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1",
        "output": "202"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.Brc1ccc2nnc(-c3cccc(OCc4ccccc4)c3)n2c1.ClCCl.O=C([O-])O.[Na+]>>Oc1cccc(-c2nnc3ccc(Br)cn23)c1",
        "output": "23"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)c1c(NC(=S)NC(=O)c2ccc(F)cc2)sc2c1CC(C)(C)OC2.ClCCl.O=C(O)C(F)(F)F>>CC1(C)Cc2c(sc(NC(=S)NC(=O)c3ccc(F)cc3)c2C(=O)O)CO1",
        "output": "569"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CBr.CCOc1cccc(CCc2nc3ccccc3[nH]2)c1.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOc1cccc(CCc2nc3ccccc3n2CC(C)C)c1",
        "output": "276"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N(C)C.CC(=O)O.CN1CCNCC1.COC(OC)OC.COCCOC.NC(=O)Nc1sc(-c2ccc(C=O)cc2)cc1C(N)=O.[BH3-]C#N.[N-]=C=O>>CN1CCN(Cc2ccc(-c3cc(C(N)=O)c(NC(N)=O)s3)cc2)CC1",
        "output": "567"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)C(C=C(Cl)Cl)C1C(=O)O.CN(C)C=O.ClCCl.O=S(Cl)Cl>>CC1(C)C(C=C(Cl)Cl)C1C(=O)Cl",
        "output": "53"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NC(C)(C)C(=O)O.CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)NS(=O)(=O)c1ccc(NC(=O)C(F)(F)F)cc1)OC)N(C)C(=O)[C@@H](N)C(C)C>>CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)NS(=O)(=O)c1ccc(NC(=O)C(F)(F)F)cc1)OC)N(C)C(=O)[C@@H](NC(=O)C(C)(C)NC(=O)OC(C)(C)C)C(C)C",
        "output": "133"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(Cn2nc(C)c3cc(Nc4cccc(CN5CCN(CCO)CC5)c4)cnc32)cc1.ClC(Cl)Cl.O=C(O)C(F)(F)F>>Cc1n[nH]c2ncc(Nc3cccc(CN4CCN(CCO)CC4)c3)cc12",
        "output": "978"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCBr.O=C(O)c1ccc(Cn2cc(-c3ccc(F)cc3F)nc2/C=C/c2ccc(-c3ccc(O)cc3)cc2)cc1>>CCCCOc1ccc(-c2ccc(/C=C/c3nc(-c4ccc(F)cc4F)cn3Cc3ccc(C(=O)O)cc3)cc2)cc1",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCCCCCC(=O)O.CCCCCCCCCCc1ncc(-c2ccc(O)cc2)s1.ClCCl.c1cc(N2CCCC2)ccn1>>CCCCCCCCCCc1ncc(-c2ccc(OC(=O)CCCCCC)cc2)s1",
        "output": "108"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)Cc1cccc(CCOS(C)(=O)=O)c1.CN(C)C=O.[N-]=[N+]=[N-].[Na+]>>CCOC(=O)Cc1cccc(CCN=[N+]=[N-])c1",
        "output": "322"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Cl.NCCNC(=O)c1cc(C(=O)O)cc([N+](=O)[O-])c1.O>>NCCNC(=O)c1cc(N)cc(C(=O)O)c1",
        "output": "489"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cl.Cn1c(CCCl)nc2cc(Br)c3ccccc3c21.O.[Na+].[OH-].c1ccc(CN2CCNCC2)cc1>>Cn1c(CCN2CCN(Cc3ccccc3)CC2)nc2cc(Br)c3ccccc3c21",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.CC1C(C)(C)c2ccccc2C1(C)C.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)c1ccc2c(c1)C(C)(C)C(C)C2(C)C",
        "output": "31"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCOCCOc1ccc(-c2ccc(N(CC(C)C)CC(C)C)c(/C=C/C(=O)OCC)c2)cc1.CCO.Cl.[Na+].[OH-]>>CCCCOCCOc1ccc(-c2ccc(N(CC(C)C)CC(C)C)c(/C=C/C(=O)O)c2)cc1",
        "output": "122"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CC(=O)[O-].O=C1CCC(=O)N1Br.O=Cc1cccc(F)c1O.[NH4+]>>O=Cc1cc(Br)cc(F)c1O",
        "output": "4"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCCCCCc1ccco1.Oc1c(Cl)cc(-c2cccs2)cc1Cl>>Clc1cc(-c2cccs2)cc(Cl)c1OCCCCCc1ccco1",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc(N(C)C)c(F)cc1N.[BH4-].[Na+]>>COc1ccc(F)c(N(C)C)c1",
        "output": "324"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O.OCCCCCCCCBr.Oc1ccc(-c2ccccc2)cc1.[Na+].[OH-]>>OCCCCCCCCOc1ccc(-c2ccccc2)cc1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1ncc(Br)nc1Br.OCC1CCNCC1>>Nc1ncc(Br)nc1N1CCC(CO)CC1",
        "output": "211"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1ncc2cc(NCc3ccc(OC)cc3)ccc2c1O.C[O-].NCCCCC(=O)O.[Na+]>>COc1ccc(CNc2ccc3c(O)c(C(=O)NCCCCC(=O)O)ncc3c2)cc1",
        "output": "487"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CNC(=O)c1ccc(C=CC(=O)NCc2cccn2-c2ccc(Cl)c(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)c2Cl)cc1.[F-]>>CNC(=O)c1ccc(C=CC(=O)NCc2cccn2-c2ccc(Cl)c(CO)c2Cl)cc1",
        "output": "781"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CN[C@H](CN2CCCC2)C1.CCN(CC)CC.ClCCl.O=C(Cl)c1ccc(F)cc1>>O=C(c1ccc(F)cc1)N1CCC[C@H]1CN1CCCC1",
        "output": "201"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O.O=[N+]([O-])c1ccc(F)cc1.OCCCCO.[K+].[OH-]>>O=[N+]([O-])c1ccc(OCCCCO)cc1",
        "output": "485"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCc1nc(N)nc(-c2ccc(C(=O)OC)c(Cl)c2)c1C#Cc1ccc(N)nc1>>CCc1nc(N)nc(-c2ccc(C(=O)O)c(Cl)c2)c1C#Cc1ccc(N)nc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCBr.CN(C)C=O.N#Cc1cc(C(O)C(F)(F)F)ccn1.O=C([O-])[O-].[Cl-].[K+].[K+].[NH4+]>>C=CCOC(c1ccnc(C#N)c1)C(F)(F)F",
        "output": "120"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.O.O=C(Cc1cccc(-n2cc(-c3n[nH]c4ccccc34)nn2)c1)N1CCOCC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>c1cc(CCN2CCOCC2)cc(-n2cc(-c3n[nH]c4ccccc34)nn2)c1",
        "output": "112"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCCCBr.OCCCc1ccccc1>>BrCCCCCOCCCc1ccccc1",
        "output": "95"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN.CO.CS(=O)(=O)c1cc(Br)ccc1CBr>>CNCc1ccc(Br)cc1S(C)(=O)=O",
        "output": "446"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2)CN1c1cc(C)nn1-c1ccnc(Cl)c1.[Li+].[OH-]>>Cc1cc(N2C[C@H](S(=O)(=O)c3ccccc3)C[C@H]2C(=O)O)n(-c2ccnc(Cl)c2)n1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(=O)(=O)Oc1cc([N+](=O)[O-])c(F)cc1Cl.Cl.O.[Fe].[Na+].[OH-]>>CS(=O)(=O)Oc1cc(N)c(F)cc1Cl",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCCCBr.CCC(C)=O.O=C([O-])[O-].Oc1ccc(O)cc1.[K+].[K+]>>Oc1ccc(OCCCBr)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1C[C@H](Cc2ccc(Cl)c(Cl)c2)C[C@H]1CO.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)N1C[C@H](Cc2ccc(Cl)c(Cl)c2)C[C@H]1COS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN1CCCC1=O.Cl.Cl.N#CCCc1c(-c2ccccc2)c(=O)[nH]c2cc(Cl)ccc12.O.[N-]=[N+]=[N-].[Na+]>>O=c1[nH]c2cc(Cl)ccc2c(CCc2nnn[nH]2)c1-c1ccccc1",
        "output": "366"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1ccc2cccnc2c1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.CS(C)=O.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc3cccnc3c2)OC1(C)C",
        "output": "934"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCc1ccccc1.CCO.O.Oc1cc(O)nc(S)n1.[Na+].[OH-]>>Oc1cc(O)nc(SCc2ccccc2)n1",
        "output": "699"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#Cc1ccc(-c2ccc(Cl)cc2)cn1.OC/C=C/c1ccc(I)cn1>>OC/C=C/c1ccc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)cn1",
        "output": "819"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCN(N)CC1.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC1(CC1)C(=O)N2C.F[B-](F)(F)F>>COc1cc(C(=O)NN2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC1(CC1)C(=O)N2C",
        "output": "55"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCOC(=O)N1CCC(Nc2nc(C(C)(C)C)cn3c(=O)[nH]nc23)CC1.[K+].[OH-]>>CC(C)(C)c1cn2c(=O)[nH]nc2c(NC2CCNCC2)n1",
        "output": "283"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN1CCOCC1.COCCN1C(=O)[C@@H](N)CC=C[C@H]1c1ccccc1.C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O.Cl.ClCCl>>COCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)Cc2cc(F)cc(F)c2)CC=C[C@H]1c1ccccc1",
        "output": "133"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Nc1ccc(O)cc1[N+](=O)[O-].[Pd]>>Nc1ccc(O)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CN(C)C(=O)COC1CCN(C(=O)OCc2ccccc2)CC1.[Pd]>>CN(C)C(=O)COC1CCNCC1",
        "output": "428"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)N.O=Cc1cc(-c2ccc(C(F)(F)F)c(Cl)c2)cc(-c2ccc(C(F)(F)F)c(Cl)c2)c1O>>CC(C)(C)NCc1cc(-c2ccc(C(F)(F)F)c(Cl)c2)cc(-c2ccc(C(F)(F)F)c(Cl)c2)c1O",
        "output": "468"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc2c(O)cc(-c3nc(C4CC4)cs3)nc2c1Cl.O=P(Cl)(Cl)Cl>>COc1ccc2c(Cl)cc(-c3nc(C4CC4)cs3)nc2c1Cl",
        "output": "177"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(OCc4ccccc4)cccc32)C1.CCOC(C)=O.[Pd]>>CC(C)(C)OC(=O)N1CCCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(O)cccc32)C1",
        "output": "264"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O.OCCCCOC1CC1>>O=CCCCOC1CC1",
        "output": "142"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC)CC(=O)Nc1cccc(N)c1.Cl.O.O=C([O-])O.[N-]=[N+]=[N-].[Na+].[Na+]>>CCN(CC)CC(=O)Nc1cccc(N=[N+]=[N-])c1",
        "output": "189"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC1=NC(c2cc(N)ccc2F)(C(F)F)CN(C(=O)OC(C)(C)C)C1.CCN(CC)CC.CCOC(C)=O.Cl.ClCCCl.ClCCl.O=C(O)c1ccc(Br)cn1.On1nnc2cccnc21>>CC(C)(C)OC(=O)NC1=NC(c2cc(NC(=O)c3ccc(Br)cn3)ccc2F)(C(F)F)CN(C(=O)OC(C)(C)C)C1",
        "output": "985"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC1CCN(C(=O)OCc2cc(C#N)cc(C(F)(F)F)c2)CC1.Cl.ClCCl>>N#Cc1cc(COC(=O)N2CCC(N)CC2)cc(C(F)(F)F)c1",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.COCCBr.Cl.O.O=C([O-])[O-].O=C1CCNCC1.[K+].[K+]>>COCCN1CCC(=O)CC1",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)[C@@H]1CCC(=O)N1C.Cl.O.[Na+].[OH-]>>CN1C(=O)CC[C@H]1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)C(CCC(=O)N1CCC(N3CCCC3=O)CC1)C(c1ccccc1)=C2C1CCCCC1.Cl.[Na+].[OH-]>>O=C(O)c1ccc2c(c1)C(CCC(=O)N1CCC(N3CCCC3=O)CC1)C(c1ccccc1)=C2C1CCCCC1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#Cc1cccc(OCCOC)c1.C1CCOC1.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Nc1ncc([N+](=O)[O-])cc1Br.[Cu]I>>COCCOc1cccc(C#Cc2cc([N+](=O)[O-])cnc2N)c1",
        "output": "719"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cccc(C)c1.Cc1ccccc1.Cl[Fe](Cl)Cl.O.O=C(Cl)c1c(Cl)cccc1Cl>>COc1ccc(C(=O)c2c(Cl)cccc2Cl)c(C)c1",
        "output": "61"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@H]1CN(c2ccncc2N)C[C@@H](NC(=O)OC(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C.F[P-](F)(F)(F)(F)F.O.O=C(O)c1ccc2cc(C3CC3)oc2n1>>C[C@H]1CN(c2ccncc2NC(=O)c2ccc3cc(C4CC4)oc3n2)C[C@@H](NC(=O)OC(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C",
        "output": "776"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.C[C@H](N)C(=O)OCCOc1ccc(-c2c(C#N)c(SCc3csc(-c4ccc(Cl)cc4)n3)nc(N3CCCC3)c2C#N)cc1.Cl.O.O.O=C(O)C(F)(F)F.On1nnc2ccccc21>>C[C@H](NC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)C(=O)OCCOc1ccc(-c2c(C#N)c(SCc3csc(-c4ccc(Cl)cc4)n3)nc(N3CCCC3)c2C#N)cc1",
        "output": "107"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCNC(=O)Nc1nc(C)c(-c2ccc(OC)cc2)s1.ClCCl.O=S(=O)(O)Cl>>CCNC(=O)Nc1nc(C)c(-c2ccc(OC)c(S(=O)(=O)Cl)c2)s1",
        "output": "357"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCI.CS(C)=O.O.O=C([O-])[O-].O=Cc1cccc(O)c1.[Cl-].[Cs+].[Cs+].[Na+]>>CCOc1cccc(C=O)c1",
        "output": "198"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOc1cc(C(Nc2ccc3cnc(NC(C)=O)cc3c2)C(=O)OC)ccc1OC(C)C.O.[Li+].[OH-]>>CCOc1cc(C(Nc2ccc3cnc(NC(C)=O)cc3c2)C(=O)O)ccc1OC(C)C",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(n2cc(N)cn2)C1.CCOC(C)=O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CN1CCC(n2cc(N)cn2)C1",
        "output": "881"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CS(C)=O.C[C@H]1CN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CCN1.C[C@H]1CN(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)CCN1.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2cccnc2c1>>C[C@H]1CN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CCN1C(=O)c1ccc2cccnc2c1",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COC(=O)Cc1ccc(C=O)cc1.Nc1cccc(-c2c(C(=O)c3ccccc3)cnc3c(C(F)(F)F)cccc23)c1.[Na+]>>COC(=O)Cc1ccc(CNc2cccc(-c3c(C(=O)c4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)cc1",
        "output": "359"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCN1C(=O)C(O)(c2cc3c(cc2O)OCO3)c2c(Br)cccc21.CCOC(=O)CN1C(=O)C(O)(c2cc3c(cc2O)OCC3)c2cc(Cl)ccc21>>CCOC(=O)CN1C(=O)C(c2cc3c(cc2O)OCC3)c2cc(Cl)ccc21",
        "output": "964"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCCN1CCCCC1.CCNCC.CN(C)C=O.COc1ccc(C2CN(C)Cc3nc(Cl)ccc32)cc1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(C2CN(C)Cc3nc(C#CCCN4CCCCC4)ccc32)cc1",
        "output": "818"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N(C)C.CCOC(C)=O.COc1ccc2c(O)c(C(=O)NCC(=O)O)nc(Cl)c2c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])O.[C-]#N.[C-]#N.[Fe+2].[Na+].[Pd].[Pd].[Zn+2].[Zn].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1ccc2c(O)c(C(=O)NCC(=O)O)nc(C#N)c2c1",
        "output": "726"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Cc1cccc(C)c1CCCBr.O=C([O-])[O-].[K+].[K+].c1ccc2[nH]c(CN3CCCCC3)nc2c1>>Cc1cccc(C)c1CCCn1c(CN2CCCCC2)nc2ccccc21",
        "output": "276"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(NC(=O)c1ccc2cncc(Br)c2n1)C(C)(C)O.OB(O)c1ccccc1Cl>>CC(NC(=O)c1ccc2cncc(-c3ccccc3Cl)c2n1)C(C)(C)O",
        "output": "871"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cl.N[C@@H]1CC[C@H](C(=O)O)CC1.OCc1ccccc1.[Na+].[OH-]>>N[C@@H]1CC[C@H](C(=O)OCc2ccccc2)CC1",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1csc(Nc2cc(OCc3ccccc3)ccn2)n1.Cl>>Cc1csc(Nc2cc(O)ccn2)n1",
        "output": "23"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)Cl.COc1cc2c(cc1C(=O)N1CCC(Cc3ccc(F)cc3)CC1)c(C(=O)C(=O)N(C)C)cn2N.c1ccncc1>>COc1cc2c(cc1C(=O)N1CCC(Cc3ccc(F)cc3)CC1)c(C(=O)C(=O)N(C)C)cn2NC(C)=O",
        "output": "450"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)O[Na].Cc1ccccc1.Fc1ccc(Br)cc1F.NC1CC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Fc1ccc(NC2CC2)cc1F",
        "output": "519"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCCCCCBr.CCCC[NH+](CCCC)CCCC.CCOCC.Cc1oc(-c2ccccc2)nc1CCO.[Br-].[Na+].[OH-]>>Cc1oc(-c2ccccc2)nc1CCOCCCCCBr",
        "output": "95"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.COC(=O)Cc1ccc(O)cc1.OCCCN1CCCCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)Cc1ccc(OCCCN2CCCCCC2)cc1",
        "output": "478"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CNC(=O)C(Cc1ccc2ccccc2c1)N1CCN(C(=O)OC(C)(C)C)C(CCO[Si](C)(C)C(C)(C)C)C1.[F-]>>CNC(=O)C(Cc1ccc2ccccc2c1)N1CCN(C(=O)OC(C)(C)C)C(CCO)C1",
        "output": "708"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.O=C1CCc2c(F)ccc(O)c21.[H][H].[Pd]>>Oc1ccc(F)c2c1CCC2",
        "output": "92"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCNC.CN1CCCC1=O.Cc1cc(C=O)cc(C(=O)O)c1.ClCCl.[Na+]>>CCN(C)Cc1cc(C)cc(C(=O)O)c1",
        "output": "567"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCNCC1.O=C1CCN(c2ccc(CN3CCOCC3)cc2)CC1>>CN1CCN(C2CCN(c3ccc(CN4CCOCC4)cc3)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)NC(C(=O)OC(C)(C)C)C(C(O)CNS(=O)(=O)c1ccccc1)N1CCc2ccccc2C1=O.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCOCC.ClCCl>>CC(=O)NC(C(=O)OC(C)(C)C)C(C(=O)CNS(=O)(=O)c1ccccc1)N1CCc2ccccc2C1=O",
        "output": "87"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CC1(C)CNCCN1.CCN(C(C)C)C(C)C.CCOC(=O)c1ccc(F)cc1>>CCOC(=O)c1ccc(N2CCNC(C)(C)C2)cc1",
        "output": "773"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N(C)C.CC(=O)Nc1nc2ccc(Oc3ccc(F)c(N)c3)nc2s1.CC(C)(C#N)c1cc(C(=O)O)ccc1Cl.CN(C)C=O.O.O=C(Cl)C(=O)Cl>>CC(=O)Nc1nc2ccc(Oc3ccc(F)c(NC(=O)c4ccc(Cl)c(C(C)(C)C#N)c4)c3)nc2s1",
        "output": "50"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCCCC1.CCO.CCOC(=O)CC1OCCc2cc(Br)ccc21.Cc1ccccc1.O.[Na+].[OH-]>>O=C(O)CC1OCCc2cc(Br)ccc21",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(O)c1ccc2[nH]cnc2c1.Oc1ccc2c(c1)C[C@@H]1NCCC[C@H]21>>O=C(c1ccc2[nH]cnc2c1)N1CCC[C@@H]2c3ccc(O)cc3C[C@@H]21",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1ccc(Cl)nc1Cl.Oc1ccc(OC(F)(F)F)cc1>>CCOC(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)nc1Cl",
        "output": "516"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CNc1cc(Cl)nc(Cl)c1.O=S(=O)(O)O.O=[N+]([O-])O>>CNc1cc(Cl)nc(Cl)c1[N+](=O)[O-]",
        "output": "328"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(N)CO.Cc1ccc(S(=O)(=O)O)cc1.O=Cc1ccccc1.c1ccccc1>>CC(C)(CO)NCc1ccccc1",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cc1ccccc1.FC(F)(F)c1ccc2c(c1)N(Cc1cccc(Br)c1)CCC2.O=C([O-])[O-].OCc1ccc(B(O)O)cc1.[Na+].[Na+]>>OCc1ccc(-c2cccc(CN3CCCc4ccc(C(F)(F)F)cc43)c2)cc1",
        "output": "908"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.Cn1nccc1CCO.O.Oc1ccc(C(F)(F)F)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cn1nccc1CCOc1ccc(C(F)(F)F)cc1",
        "output": "478"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=C1c2ccccc2COc2ccc(C(=O)OC)cc21.CCO.Cl.O.[Na+].[OH-]>>C=C1c2ccccc2COc2ccc(C(=O)O)cc21",
        "output": "222"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cl.ClCCNCCCl.Nc1ccc(N2CCN(Cc3ccccc3)CC2)cc1.[I-].[Na+]>>c1ccc(CN2CCN(c3ccc(N4CCNCC4)cc3)CC2)cc1",
        "output": "640"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "N#Cc1ccc(CCOc2cc(O)cc(Cl)c2)cc1.O.O=S(=O)(Cl)c1ccc(F)cc1Cl.c1ccncc1>>N#Cc1ccc(CCOc2cc(Cl)cc(OS(=O)(=O)c3ccc(F)cc3Cl)c2)cc1",
        "output": "380"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)Cc1cccc(OCCCC2CCN(C(=O)OC(C)(C)C)CC2)c1.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(CCCOc2cccc(CC(=O)O)c2)CC1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(CC(O)C2CCCCC2)c2nc(C)nn12.CCOC(C)=O.Cc1cccc(C)n1>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(CC(O[Si](C)(C)C(C)(C)C)C2CCCCC2)c2nc(C)nn12",
        "output": "839"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.COCCC(C(=O)O)n1cc(OC)c(-c2cc(Cl)ccc2C#N)cc1=O.NC(=O)c1cn2ccc(N)cc2n1.c1ccncc1>>COCCC(C(=O)Nc1ccn2cc(C(N)=O)nc2c1)n1cc(OC)c(-c2cc(Cl)ccc2C#N)cc1=O",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1ccc(-c2nc(Cl)c3cc(Cl)sc3n2)cc1.NCc1cccc([N+](=O)[O-])c1>>COC(=O)c1ccc(-c2nc(NCc3cccc([N+](=O)[O-])c3)c3cc(Cl)sc3n2)cc1",
        "output": "906"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(N=[N+]=[N-])c1cc(C(F)(F)F)cc(C(F)(F)F)c1.CO.[H][H].[Pd]>>CC(N)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "562"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.Cc1cccc(C)c1N1C[C@](C(=O)O)(C(C)C)CC1=O.N#Cc1cc(N)cc(C(F)(F)F)c1>>Cc1cccc(C)c1N1C[C@](C(=O)Nc2cc(C#N)cc(C(F)(F)F)c2)(C(C)C)CC1=O",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)C(O)c1ccccc1Cl.CCOCC.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CC(C)C(=O)c1ccccc1Cl",
        "output": "32"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CSc1ccc2nc(C(F)(F)F)nc(Cl)c2c1.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1ccc2nc(C(F)(F)F)nc(Cl)c2c1",
        "output": "500"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3[nH]c(C(=O)O)c(-c4cccc(C(F)(F)F)c4)c3c2)cc1.CN(C)CCN.CO.ClCCl>>CN(C)CCNC(=O)c1[nH]c2ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)cc2c1-c1cccc(C(F)(F)F)c1",
        "output": "137"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4CC)n2)CCNC3)cc1.CN(C)C=O.O=C1CCOCC1.[Na+]>>CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4CC)n2)CCN(C2CCOCC2)C3)cc1",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC#Cc1ccc(C=O)c(C)c1C.CCOC(C)=O.[Pd]>>CCCCCc1ccc(C=O)c(C)c1C",
        "output": "717"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN1CCNCC1.CCOC(=O)CBr.Cc1ccccc1>>CCOC(=O)CN1CCN(CC)CC1",
        "output": "467"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN.Cc1ccc(S(=O)(=O)OCC2Cc3cc(Cl)cc(-c4c(C)cccc4C)c3O2)cc1>>CCNCC1Cc2cc(Cl)cc(-c3c(C)cccc3C)c2O1",
        "output": "853"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CCOCCN(C)C(=O)c1ccc(CCS(=O)(=O)N2CCC(N)(C#N)CC2)c(C)c1.CO.CS(C)=O.O=S([O-])[O-].OO.[Na+].[Na+].[Na+].[OH-]>>C=CCOCCN(C)C(=O)c1ccc(CCS(=O)(=O)N2CCC(N)(C(N)=O)CC2)c(C)c1",
        "output": "632"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CN(C)C=O.Cc1nn(-c2ccc(C#N)c(Cl)c2)c(CO)c1Cc1ccc(C(=O)NCC(C)(C)O)cc1.[Mn+4].[O-2].[O-2]>>Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C=O)c1Cc1ccc(C(=O)NCC(C)(C)O)cc1",
        "output": "573"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.Cl.ClC(Cl)Cl.NCCc1c[nH]c2ccc(OCc3ccccc3)cc12.O=C1OC(=O)c2ccccc21.c1ccncc1>>O=C1c2ccccc2C(=O)N1CCc1c[nH]c2ccc(OCc3ccccc3)cc12",
        "output": "341"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Clc1ccc2cc[nH]c2c1.O.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>O=Cc1c[nH]c2cc(Cl)ccc12",
        "output": "266"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.O=c1c2ccccc2nnn1CCCN1CC=C(c2c[nH]c3ccccc23)CC1>>Cn1cc(C2=CCN(CCCn3nnc4ccccc4c3=O)CC2)c2ccccc21",
        "output": "191"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1cc(C(=O)O)no1.C[C@H](N)Cn1ccc(-c2cc(F)c(C#N)c(Cl)c2)n1>>CC(=O)c1cc(C(=O)N[C@@H](C)Cn2ccc(-c3cc(F)c(C#N)c(Cl)c3)n2)no1",
        "output": "696"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#CCN(C)C.CCNCC.CN(C)C=O.Cn1nc(NS(C)(=O)=O)c2cccc(-c3ccc(Cl)nc3[C@H](Cc3cc(F)cc(F)c3)NC(=O)Cn3nc(C(F)(F)F)c4c3C(F)(F)[C@@H]3C[C@H]43)c21>>CN(C)CC#Cc1ccc(-c2cccc3c(NS(C)(=O)=O)nn(C)c23)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)(F)F)c3c2C(F)(F)[C@@H]2C[C@H]32)n1",
        "output": "818"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.CCc1c(CCN2CC(C(=O)OC)C2)cccc1-c1cnc(-c2ccc(OC(C)C)c(C#N)c2)s1.O.[Na+].[OH-]>>CCc1c(CCN2CC(C(=O)O)C2)cccc1-c1cnc(-c2ccc(OC(C)C)c(C#N)c2)s1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CO.Cl.N#Cc1ccc(-n2c3c(c4ccccc42)C(=O)CCC3)c(Br)c1.NO>>N=C(NO)c1ccc(-n2c3c(c4ccccc42)C(=O)CCC3)c(Br)c1",
        "output": "854"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.CCOC(C)=O.COC[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(CSCc4ccccc4)nc32)[C@H](O)[C@@H]1O.ClCCl.O.O=C([O-])O.O=S([O-])OO.[K+].[Na+]>>COC[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(CS(=O)(=O)Cc4ccccc4)nc32)[C@H](O)[C@@H]1O",
        "output": "847"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.Cc1ccc(CC(=O)O)s1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1ccc(CCO)s1",
        "output": "231"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CI.CN(C)C=O.Cc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(N)nc(Cl)c12>>CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cc(C)c2c(Cl)nc(N)nc21",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.Cc1ccc(CO)cn1>>Cc1ccc(COS(C)(=O)=O)cn1",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCC.CCN(CC)CC.CCOCC.CS(C)=O.Cc1c(CO)nn(-c2ccccc2Cl)c1-c1ccc(Cl)cc1.ClCCl.O=C(Cl)C(=O)Cl>>Cc1c(C=O)nn(-c2ccccc2Cl)c1-c1ccc(Cl)cc1",
        "output": "573"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2c(F)cc([N+](=O)[O-])cc2F)CC1.CCO.[Pd]>>CC(C)(C)OC(=O)N1CCC(Oc2c(F)cc(N)cc2F)CC1",
        "output": "202"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.CS(=O)(=NC#N)c1ccc(CN2C(=O)c3ccccc3C2=O)cc1F.ClCCl.NN>>CS(=O)(=NC#N)c1ccc(CN)cc1F",
        "output": "418"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NCCCc1ccccc1.NCc1ccc(C(F)(F)F)cc1.O=C(O)c1ccnc(NC(=O)c2ccccc2)c1>>O=C(NCCCc1ccccc1)c1ccnc(NC(=O)c2ccccc2)c1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)CNc1ccc(C(F)(F)F)cc1.CO.O.O.[Li+].[OH-]>>O=C(O)CNc1ccc(C(F)(F)F)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)c1nccc(Oc2ccc(NC(=O)c3cc(F)cc(N4CCOCC4)c3)c3ccccc23)n1.OC1CCCNC1>>O=C(Nc1ccc(Oc2ccnc(N3CCCC(O)C3)n2)c2ccccc12)c1cc(F)cc(N2CCOCC2)c1",
        "output": "679"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)CCc1cc(F)cc(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)c1OC.Cl.O.[Na+].[OH-]>>COc1c(CCC(=O)O)cc(F)cc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1c1cc(C)nn1C(C)(C)C.[Li+].[OH-]>>Cc1cc(N2C[C@H](S(=O)(=O)c3ccccc3C(F)(F)F)C[C@H]2C(=O)O)n(C(C)(C)C)n1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CNOC.COc1ccc(-n2nc(C(F)(F)F)c3c2C(=O)N(c2ccc(C4(C(=O)O)CC4)cc2)CC3)cc1.Cl.Cl>>COc1ccc(-n2nc(C(F)(F)F)c3c2C(=O)N(c2ccc(C4(C(=O)N(C)OC)CC4)cc2)CC3)cc1",
        "output": "54"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN.CN(C)C=O.ClCCCl.O=C(O)C[C@@H]1CSC(c2cc3cc(Cl)cc(NC4CCOCC4)c3[nH]2)=N1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CNC(=O)C[C@@H]1CSC(c2cc3cc(Cl)cc(NC4CCOCC4)c3[nH]2)=N1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCN1.CCN1CCOCC1.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cc1cn(C(=O)OC(C)(C)C)c2c(Cl)ncc(C(=O)O)c12.Cl.O.On1nnc2ccccc21>>Cc1cn(C(=O)OC(C)(C)C)c2c(Cl)ncc(C(=O)N3CCOCC3)c12",
        "output": "256"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C(=N)NC1=NC(=O)C(=Cc2ccc(N3CCC(=O)CC3)cc2)S1.NC[C@H](O)COc1ccc(O)cc1>>CN(C)C(=N)NC1=NC(=O)C(=Cc2ccc(N3CCC(NC[C@H](O)COc4ccc(O)cc4)CC3)cc2)S1",
        "output": "236"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCC1CC2CCC(C1)N2.CCCCCCC.CCOC(C)=O.C[C@H](CI)CN1C(=O)COc2cc(F)ccc21>>CCCCCC1CC2CCC(C1)N2C[C@@H](C)CN1C(=O)COc2cc(F)ccc21",
        "output": "184"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#Cc1cc(Cl)ccc1OCC(=O)OC(C)(C)C.CCCS(=O)(=O)c1ccc(F)c(C#C[Si](C)(C)C)c1.COCCS(=O)(=O)c1ccc(F)c(Br)c1>>COCCS(=O)(=O)c1ccc(F)c(C#Cc2cc(Cl)ccc2OCC(=O)OC(C)(C)C)c1",
        "output": "659"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCCCCN(C)C(=O)[C@@H]1C[C@@H](O)CN1C(=O)N[C@]1(C(=O)OCC)C[C@@H]1C=C.CC(C)(C)[Si](C)(C)Cl.ClCCl>>C=CCCCCN(C)C(=O)[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)N[C@]1(C(=O)OCC)C[C@@H]1C=C",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCOC(c2ccc(Cl)c(Cl)c2)C(Oc2ncccc2C#N)C1.CS(C)=O.O.O=C([O-])[O-].OO.[K+].[K+]>>CC(C)(C)OC(=O)N1CCOC(c2ccc(Cl)c(Cl)c2)C(Oc2ncccc2C(N)=O)C1",
        "output": "677"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCc1cccc(N)c1.O=C(O)c1cccc(-c2cc(Cl)cc(Cl)c2)n1>>CCOC(=O)CCc1cccc(NC(=O)c2cccc(-c3cc(Cl)cc(Cl)c3)n2)c1",
        "output": "548"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.CCN(CC)CC.CCOC(C)=O.COc1ccc2nc(Cl)c(C#N)c(-c3cccc(F)c3)c2c1.O[C@@H]1CNC[C@H]1O>>COc1ccc2nc(N3C[C@@H](O)[C@H](O)C3)c(C#N)c(-c3cccc(F)c3)c2c1",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCc1cccc(-c2cnc(C(F)(F)F)cn2)c1.ClCCl.O=C(O)C(F)(F)F>>NCc1cccc(-c2cnc(C(F)(F)F)cn2)c1",
        "output": "793"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNC(=O)c1c(C)sc2cc(O)ccc12.CO[C@@H]1CCN(C(=O)c2cc3nccc(Cl)c3s2)C1.O=C([O-])[O-].[Cs+].[Cs+]>>CNC(=O)c1c(C)sc2cc(Oc3ccnc4cc(C(=O)N5CC[C@@H](OC)C5)sc34)ccc12",
        "output": "936"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OCCN1CCC(Oc2cc(F)cc3nc[nH]c(=O)c23)CC1.CO>>COc1cc(OC2CCN(CCOC(C)(C)C)CC2)c2c(=O)[nH]cnc2c1",
        "output": "636"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Cl.Cl.O=C(OCc1ccccc1)N1CCN2[C@H](CNC[C@H]2C(c2ccc(F)cc2)c2ccc(F)cc2)C1>>CC(C)(C)OC(=O)N1C[C@@H]2CN(C(=O)OCc3ccccc3)CCN2[C@H](C(c2ccc(F)cc2)c2ccc(F)cc2)C1",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(Cl)cc2c(-c3ccc(Cl)cc3)onc12.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>Clc1ccc(-c2onc3c(CBr)cc(Cl)cc23)cc1",
        "output": "625"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CI.CN(C)C=O.COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCCNCC4)cc3)nc2c1>>COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCCN(C)CC4)cc3)nc2c1",
        "output": "483"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.N.N#Cc1cccc(Oc2ccccc2)c1.[H][H].[Ni]>>NCc1cccc(Oc2ccccc2)c1",
        "output": "175"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCN(CCCC)C(=O)c1cn(CCc2ccccc2)c(-c2ccc(C(=O)OC)cc2C(=O)OCc2ccccc2)n1.CO.[Pd]>>CCCCN(CCCC)C(=O)c1cn(CCc2ccccc2)c(-c2ccc(C(=O)OC)cc2C(=O)O)n1",
        "output": "290"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)c1cc(Cl)ncc1C(=O)NCC1CCOCC1.Nc1ccc(Br)c(Br)c1>>CC(C)c1cc(Nc2ccc(Br)c(Br)c2)ncc1C(=O)NCC1CCOCC1",
        "output": "434"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CCOC(=O)c1c(-c2ccc(OS(=O)(=O)C(F)(F)F)cc2)c(C#N)c(C(F)(F)F)n1C.N#Cc1ccccc1B(O)O.O=P(Oc1ccccc1)(Oc1ccccc1)Oc1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd+2]>>CCOC(=O)c1c(-c2ccc(-c3ccccc3C#N)cc2)c(C#N)c(C(F)(F)F)n1C",
        "output": "825"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)C1(N)CC2CCC1(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C2.[Na+].[OH-]>>NC1(C(=O)O)CC2CCC1(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1)C2",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)C[AlH]CC(C)C.CCOC(=O)c1ccc2c(F)ccc(Br)c2n1.ClCCl>>OCc1ccc2c(F)ccc(Br)c2n1",
        "output": "711"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc2c(c(Cl)c1OCC(C)(N)C#N)B(O)OC2.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(OC(F)(F)F)cc1>>Cc1cc2c(c(Cl)c1OCC(C)(C#N)NC(=O)c1ccc(OC(F)(F)F)cc1)B(O)OC2",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.NC(=O)c1ccc(Oc2cnc(C=O)c3ccccc23)c(F)c1.NC1Cc2ccccc2C1>>NC(=O)c1ccc(Oc2cnc(CNC3Cc4ccccc4C3)c3ccccc23)c(F)c1",
        "output": "775"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.COc1nc(SC[C@H](NC(=O)OC(C)(C)C)C(=O)O)cnc1N(COCC[Si](C)(C)C)S(=O)(=O)c1cccc(Cl)c1Cl.N.[Cl-].[NH4+]>>COc1nc(SC[C@H](NC(=O)OC(C)(C)C)C(N)=O)cnc1N(COCC[Si](C)(C)C)S(=O)(=O)c1cccc(Cl)c1Cl",
        "output": "313"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.COc1ccc2c(=O)n(-c3ccc(F)cc3)ccc2c1.O=C1CCC(=O)N1Br>>COc1ccc2c(=O)n(-c3ccc(F)cc3)cc(Br)c2c1",
        "output": "518"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.O=C(O)c1ccc([N+](=O)[O-])cc1C(=O)O>>Nc1ccc(C(=O)O)c(C(=O)O)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCOCCn1c(=O)c(Cl)nc2cnc(Cl)cc21.CCN(CC)CC.OCCN1CCNCC1>>CCCOCCn1c(=O)c(N2CCN(CCO)CC2)nc2cnc(Cl)cc21",
        "output": "505"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#Cc1ccc(C)cc1CC(=O)O.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl>>C#Cc1ccc(C)cc1CC(=O)Cl",
        "output": "56"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CC(C(=O)O)C2)nc1C(F)F.Cc1cccc(CS(N)(=O)=O)c1>>CCOC(=O)c1cc(C#N)c(N2CC(C(=O)NS(=O)(=O)Cc3cccc(C)c3)C2)nc1C(F)F",
        "output": "644"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCN(CCC)CCCCN(C)C(C(=O)OCC)c1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1.Cl>>CCCN(CCC)CCCCN(C)C(C(=O)O)c1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COc1cc(C(=O)O)cc([N+](=O)[O-])c1.O=S(Cl)Cl>>CCOC(=O)c1cc(OC)cc([N+](=O)[O-])c1",
        "output": "33"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCCCC1.C1CCOC1.CCOC(=O)Nc1ccccc1OC(F)(F)F.II.[Li]C(C)CC>>CCOC(=O)Nc1c(I)cccc1OC(F)(F)F",
        "output": "372"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3ccc([N+](=O)[O-])c(C(F)(F)F)c3)S(C)(=O)=O)c(C3CC3)cc12.CO.[Pd]>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3ccc(N)c(C(F)(F)F)c3)S(C)(=O)=O)c(C3CC3)cc12",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)[C@@H](Cc1ccc(C)c(Cl)c1)OC(=O)N1CCC(N2CCc3ccccc3NC2=O)CC1.O.[Li+].[OH-]>>Cc1ccc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc1Cl",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.Cl.ClCCl.Nc1cccc(-c2nn(C3CCCCO3)c3ccc(-c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1.O=C(O)Cc1ccc(F)cc1>>O=C(Cc1ccc(F)cc1)Nc1cccc(-c2nn(C3CCCCO3)c3ccc(-c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.COc1cc(C(C)(C)c2cnc(SCc3c(F)cc(OCCCO)cc3Cl)n2-c2ccc(F)cc2)ccc1F.CS(=O)(=O)Cl.ClCCl>>COc1cc(C(C)(C)c2cnc(SCc3c(F)cc(OCCCOS(C)(=O)=O)cc3Cl)n2-c2ccc(F)cc2)ccc1F",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.Nc1cc(-c2cnc3ccccc3c2)n[nH]1.[K+].[OH-]>>CC(C)(C)OC(=O)n1nc(-c2cnc3ccccc3c2)cc1N",
        "output": "841"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.Cl.ClCCl.NCc1ccc(-c2oc(-c3c(F)cccc3F)nc2C(N)=O)cc1.O=C(Cl)c1ccccc1>>NC(=O)c1nc(-c2c(F)cccc2F)oc1-c1ccc(CNC(=O)c2ccccc2)cc1",
        "output": "411"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)CCc1cccc(Br)c1>>COC(=O)CCc1cccc(B2OC(C)(C)C(C)(C)O2)c1",
        "output": "942"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cl.ClCCN1CCCC1.NCCN.O.[Na+].[OH-]>>NCCNCCN1CCCC1",
        "output": "279"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CSc1ccccc1.O=C(N[C@H]1CN(C(=O)NS(=O)(=O)NNC(=O)N2CCN(NC(=O)c3cc(=O)c(O)c[nH]3)C2=O)C1=O)OCc1ccccc1.O=C(O)C(F)(F)F>>N[C@H]1CN(C(=O)NS(=O)(=O)NNC(=O)N2CCN(NC(=O)c3cc(=O)c(O)c[nH]3)C2=O)C1=O",
        "output": "128"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(S(C)(=O)=O)cn2)CC1.ClCCl.O=C(O)C(F)(F)F>>CS(=O)(=O)c1ccc(N2CCNCC2)nc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCNCCC.CCN=C=NCCCN(C)C.CCOCC.CN(C)C=O.COc1ccc2[nH]cc(CC(=O)O)c2c1>>CCCN(CCC)C(=O)Cc1c[nH]c2ccc(OC)cc12",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c2c1OC1(CCCC1)O2.O=C(OO)c1cccc(Cl)c1>>COc1ccc(C(=O)Cc2c(Cl)c[n+]([O-])cc2Cl)c2c1OC1(CCCC1)O2",
        "output": "262"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COCC1COc2cc3ncnc(Cl)c3cc2O1.Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>COCC1COc2cc3ncnc(Nc4cc(C(F)(F)F)cc(C(F)(F)F)c4)c3cc2O1",
        "output": "352"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc2[nH]c(=O)n(-c3cc(S(=O)(=O)N4CCCc5ccccc54)ccc3Cl)c(=O)c12.Cl.O.O.[Li+].[OH-]>>O=C(O)c1cccc2[nH]c(=O)n(-c3cc(S(=O)(=O)N4CCCc5ccccc54)ccc3Cl)c(=O)c12",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cccnc1Cl.NN.O>>COc1cccnc1NN",
        "output": "417"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C(O)c1cc(C(=O)O)c(C(=O)N(Cc2cccc(Br)c2)[C@H]2CCCc3ccccc32)cc1C(=O)O.OB(O)c1ccccc1Cl>>O=C(O)c1cc(C(=O)O)c(C(=O)N(Cc2cccc(-c3ccccc3Cl)c2)[C@H]2CCCc3ccccc32)cc1C(=O)O",
        "output": "908"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.CN(C)CCN.N[C@@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccccc1)N(Cc1ccccc1)Cc1ccccc1.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccccc1)N(Cc1ccccc1)Cc1ccccc1",
        "output": "631"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCl.O=C(NC12CC3CC(CC(CO)(C3)C1)C2)c1cccc(Cl)c1.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>O=CC12CC3CC(C1)CC(NC(=O)c1cccc(Cl)c1)(C3)C2",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCc1cnc(N2CCC(CCCOc3ccc4c(n3)CCNC4)CC2)nc1.CS(=O)(=O)Cl.ClCCl>>CCc1cnc(N2CCC(CCCOc3ccc4c(n3)CCN(S(C)(=O)=O)C4)CC2)nc1",
        "output": "584"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC(Cc1ccccc1)C(O)C(N)Cc1ccccc1.Cl>>NC(Cc1ccccc1)C(O)C(N)Cc1ccccc1",
        "output": "538"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CNS(=O)(=O)c1cc(-c2cc(CCCO)nc(C#N)n2)cc(C(F)(F)F)c1.ClCCl>>CNS(=O)(=O)c1cc(-c2cc(CCC=O)nc(C#N)n2)cc(C(F)(F)F)c1",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)c1ccc(/C=C/C(=O)NC(c2cccc(C(F)(F)F)c2)C(F)(F)F)c2cc(C)oc12.Cl.[Na+].[OH-]>>Cc1cc2c(/C=C/C(=O)NC(c3cccc(C(F)(F)F)c3)C(F)(F)F)ccc(C(=O)O)c2o1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cncc(Cl)c2)CC1.Cl>>Clc1cncc(N2CCNCC2)c1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)C(CC1CCCC1)n1ncc(OCC2CCCC2)cc1=O.[Na+].[OH-]>>O=C(O)C(CC1CCCC1)n1ncc(OCC2CCCC2)cc1=O",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "O=C(N1CCc2ccccc21)C(F)(F)F.O=S(=O)(O)Cl.O=S(Cl)Cl>>O=C(N1CCc2cc(S(=O)(=O)Cl)ccc21)C(F)(F)F",
        "output": "182"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.O=[Cr](=O)([O-])Cl.OCc1cnc(Cl)cc1Cl.c1cc[nH+]cc1>>O=Cc1cnc(Cl)cc1Cl",
        "output": "520"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCn1nc(C2CCCCC2)c2c(=O)[nH]c(-c3ccc(S(=O)(=O)Cl)cc3OC)nc21.CN1CCCNCC1>>CCn1nc(C2CCCCC2)c2c(=O)[nH]c(-c3ccc(S(=O)(=O)N4CCCN(C)CC4)cc3OC)nc21",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)N1CCc2cc([N+](=O)[O-])ccc21.O=[Pt]=O.[H][H]>>CC(=O)N1CCc2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COc1ccc(-c2nc(SCC=O)sc2-c2ccc(OC)cc2)cc1.[BH4-].[Na+]>>COc1ccc(-c2nc(SCCO)sc2-c2ccc(OC)cc2)cc1",
        "output": "223"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CSc1ncc2c(n1)CCN(c1cccc(C(=O)O)n1)C2.Nc1cccc(C(F)(F)F)c1>>CSc1ncc2c(n1)CCN(c1cccc(C(=O)Nc3cccc(C(F)(F)F)c3)n1)C2",
        "output": "548"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.O=c1ccc2c([C@@H](O)CNCCCCCCOCC(F)(F)c3ccccc3)ccc(OCc3ccccc3)c2[nH]1.[Pd]>>O=c1ccc2c([C@@H](O)CNCCCCCCOCC(F)(F)c3ccccc3)ccc(O)c2[nH]1",
        "output": "264"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN1Cc2c(Cl)cc(Cl)cc2C(c2cccc(S(=O)(=O)Cl)c2)C1.ClCCl.[N-]=[N+]=NCCOCCOCCOCCN>>CCN1Cc2c(Cl)cc(Cl)cc2C(c2cccc(S(=O)(=O)NCCOCCOCCOCCN=[N+]=[N-])c2)C1",
        "output": "43"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.Cl.ClCCl.NO.O.O=Cc1c(Cl)cccc1Cl>>ON=Cc1c(Cl)cccc1Cl",
        "output": "30"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(Oc1cc(-c2cnn(C(C)C(=O)O)c2)cnc1N)c1c(Cl)ccc(F)c1Cl.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)CCCN.FP(F)(F)(F)F>>CC(Oc1cc(-c2cnn(C(C)C(=O)NCCCN(C)C)c2)cnc1N)c1c(Cl)ccc(F)c1Cl",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(CC2NCCCc3cc(OC)c(OC)cc32)cc1OC.COc1cccc2c1CCC2N.O=C(Br)CBr>>COc1ccc(CC2c3cc(OC)c(OC)cc3CCCN2CC(=O)NC2CCc3c(OC)cccc32)cc1OC",
        "output": "946"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)c1cccc(O)c1.CO[Si](CCCCl)(OC)OC.CS(C)=O.Cc1ccccc1.[Na+].[OH-]>>CCN(CC)c1cccc(OCCC[Si](OC)(OC)OC)c1",
        "output": "74"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C(Cc1ccc(OCCCc2nc(-c3ccccc3)oc2C)cc1C)OCC.[Li+].[OH-]>>CCOC(Cc1ccc(OCCCc2nc(-c3ccccc3)oc2C)cc1C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(CO)[C@@H](O)CO.CC(C)=O.Cc1ccc(S(=O)(=O)O)cc1>>CC1(C)OC[C@@H](C(C)(C)CO)O1",
        "output": "265"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cl.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3OCC4)CC2)CC1.O=C(O)C(O)C(F)(F)F>>O=C(N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3OCC4)CC2)CC1)C(O)C(F)(F)F",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.Cc1cccc(CN)c1.Cl.ClCCl.O=C(O)c1cnc2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc2c1.On1nnc2ccccc21>>Cc1cccc(CNC(=O)c2cnc3cc(NC(=O)c4ccccc4-c4ccc(C(F)(F)F)cc4)ccc3c2)c1",
        "output": "790"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccccc1.N#Cc1cnn2c1N(C(=O)CCl)CC=C2c1ccccc1.O=C([O-])[O-].[Na+].[Na+].c1ccc(CN2CCNCC2)cc1>>N#Cc1cnn2c1N(C(=O)CN1CCN(Cc3ccccc3)CC1)CC=C2c1ccccc1",
        "output": "340"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C#N)c1cccc(C(=O)O)c1Cl.CN(C)C=O.O=C(Cl)C(=O)Cl>>CC(C)(C#N)c1cccc(C(=O)Cl)c1Cl",
        "output": "448"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.ClCCN1CCCC1.Clc1ccc2[nH]nc(I)c2c1>>Clc1ccc2c(c1)c(I)nn2CCN1CCCC1",
        "output": "604"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cn1cc(-c2cc([N+](=O)[O-])ccc2OC2CCC(F)(F)CC2)c2cc[nH]c2c1=O.Cn1cc(-c2cc([N+](=O)[O-])ccc2Oc2ccccc2)c2cc[nH]c2c1=O>>Cn1cc(-c2cc(N)ccc2OC2CCC(F)(F)CC2)c2cc[nH]c2c1=O",
        "output": "202"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)N(C)S(=O)(=O)NC(=O)c1ccc(F)c([N+](=O)[O-])c1.CO.[H][H].[Pd]>>CC(C)N(C)S(=O)(=O)NC(=O)c1ccc(F)c(N)c1",
        "output": "489"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.CC(O)(C(=O)O)C(F)(F)F.COc1cc(C(=O)c2ccccc2)ccc1N.O.O=S(Cl)Cl>>COc1cc(C(=O)c2ccccc2)ccc1NC(=O)C(C)(O)C(F)(F)F",
        "output": "365"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C(=O)Cl.C[Si](C)(C)C#N.ClCCl.O=C(O)c1ccc[n+]([O-])c1>>N#Cc1ccc(C(=O)O)cn1",
        "output": "720"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(CO)(CO)NS(=O)(=O)c1cccc(N)c1.O=C(O)c1cnn2c(C(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12>>CC(CO)(CO)NS(=O)(=O)c1cccc(NC(=O)c2cnn3c(C(F)F)cc(-c4ccc(C(F)(F)F)cc4)nc23)c1",
        "output": "969"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.II.Nc1ccc(Br)cc1[N+](=O)[O-].O=S(=O)([O-])[O-].[Ag+].[Ag+]>>Nc1c(I)cc(Br)cc1[N+](=O)[O-]",
        "output": "372"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc(-c2cc(-c3cc(C(C)(C)C)cc(C(C)(C)C)c3)n(-c3ccc([N+](=O)[O-])cc3)n2)cc1.O.[Cl-].[Fe].[NH4+]>>COC(=O)c1ccc(-c2cc(-c3cc(C(C)(C)C)cc(C(C)(C)C)c3)n(-c3ccc(N)cc3)n2)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)N(C(=O)[O-])[C@H]1CCCC[C@H]1C=O.Cl.Cl.Cl.NC1CC1.NC1CCCCC1CNC1CC1.NC1CCCCC1CNC1CC1.O=C(NCc1ccc(F)cc1F)c1cn2c(c(OCc3ccccc3)c1=O)C(=O)N1C3CCCCC3CN(C3CC3)C1C2.O=C1CCC2CN(C3CC3)C3CN4C=C(C(=O)NCc5ccc(F)cc5F)CC(OCc5ccccc5)=C4CN3C2C1=O>>O=C(NCc1ccc(F)cc1F)c1cn2c(c(O)c1=O)C(=O)N1C3CCCCC3CN(C3CC3)C1C2",
        "output": "264"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCN(CC)CC.ClCCl.O=C1CCC1.O=S(=O)(Cc1ccc2c(c1)CCNCC2)c1ccccc1.[Na]>>O=S(=O)(Cc1ccc2c(c1)CCN(C1CCC1)CC2)c1ccccc1",
        "output": "187"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)C(C)=Cc1ccc(CC(C)=O)cc1.NCC(O)c1ccccc1>>CCOC(=O)C(C)=Cc1ccc(CC(C)NCC(O)c2ccccc2)cc1",
        "output": "236"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCI.O=C(Nc1ccc2cccc(N3CCNCC3)c2c1)c1ccc(Cl)cc1.[Cl-].[Li]CCCC.[NH4+]>>CCN1CCN(c2cccc3ccc(NC(=O)c4ccc(Cl)cc4)cc23)CC1",
        "output": "184"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O.O=C(O)[C@H]1C[C@@H](n2cc(-c3cn(S(=O)(=O)c4ccccc4)c4cc(F)ccc34)cn2)C1.[Cl-].[NH4+]>>NC(=O)[C@H]1C[C@@H](n2cc(-c3cn(S(=O)(=O)c4ccccc4)c4cc(F)ccc34)cn2)C1",
        "output": "313"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.Cn1c(=O)[nH]c(=O)n(-c2cc([N+](=O)[O-])c(F)cc2Cl)c1=O.[H][H].[Pt]>>Cn1c(=O)[nH]c(=O)n(-c2cc(N)c(F)cc2Cl)c1=O",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C(=O)Nc2ccccc2NC(=O)C2CCNCC2)cc1.ClCCl.O=S(=O)(Cl)c1ccccc1.c1ccncc1>>COc1ccc(C(=O)Nc2ccccc2NC(=O)C2CCN(S(=O)(=O)c3ccccc3)CC2)cc1",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrB(Br)Br.COc1ccc2c(c1)OC(C)(C)CC2.ClCCl.O=C([O-])O.[Na+]>>CC1(C)CCc2ccc(O)cc2O1",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CN(C)C=O.CS(=O)(=O)c1ccc([C@@H](C[C@@H]2CCC(=O)C2)C(=O)O)cc1Cl.Cc1ccccc1.ClCCl.Nc1cnccn1.O=C(Cl)C(=O)Cl.O=C(O)CC(O)(CC(=O)O)C(=O)O.c1ccncc1>>CS(=O)(=O)c1ccc([C@@H](C[C@@H]2CCC(=O)C2)C(=O)Nc2cnccn2)cc1Cl",
        "output": "692"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCn1nc2c(N)nc3ccccc3c2c1CC(C)(C)N.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C([O-])[O-].[Na+].[Na+]>>CCCn1nc2c(N)nc3ccccc3c2c1CC(C)(C)NS(C)(=O)=O",
        "output": "493"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOc1cccc(C=O)c1O.N=C(NN)c1nccc2ccccc12>>CCOc1cccc(-c2nc(-c3nccc4ccccc34)n[nH]2)c1O",
        "output": "994"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CCCCCCCCCCO.CN(C)C=O.O=C1CCC(=O)N1Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C=CCCCCCCCCCBr",
        "output": "581"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C(C)(C)Cc1ccc(N)cc1C(F)(F)F.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.O.O=C(O)Cc1ccc(Br)cc1F>>CCOC(=O)C(C)(C)Cc1ccc(NC(=O)Cc2ccc(Br)cc2F)cc1C(F)(F)F",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.COC(=O)C1C(=O)C[C@@H]2CC[C@H]1N2Cc1ccccc1.[Pd]>>COC(=O)C1C(=O)C[C@@H]2CC[C@H]1N2",
        "output": "84"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(C)(C)CCC3(C)C)nc1.CCOC(C)=O.CCOCC.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[H-].[Li+].[NH4+]>>CC1(C)CCC(C)(C)c2cc(C#Cc3ccc(CO)cn3)ccc21",
        "output": "383"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1cc[nH]c1/C=C1\\C(=O)Nc2cccc(C#CC(O)c3cccc([N+](=O)[O-])c3)c21.O.[Cl-].[NH4+].[Zn]>>COc1cc[nH]c1/C=C1\\C(=O)Nc2cccc(C#CC(O)c3cccc(N)c3)c21",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CCCn2c1cc(Cl)nc2=O.OCc1cc(F)c(Oc2cccc(C(F)(F)F)c2)c(F)c1>>CN1CCCn2c1cc(OCc1cc(F)c(Oc3cccc(C(F)(F)F)c3)c(F)c1)nc2=O",
        "output": "653"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](N)C1.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.ClCCl.O=C(O)C(F)F>>CC(C)(C)OC(=O)N1CC[C@H](NC(=O)C(F)F)C1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)Cl)cc1.Nc1ccc(Cl)cc1Sc1ccncc1>>CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2Sc2ccncc2)cc1",
        "output": "68"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Nc1c(I)cc(I)c(CCCCCCCCCCCC(=O)O)c1I.O=C(O)CCCCCCCCCCBr.O=S(=O)(O)O>>CCOC(=O)CCCCCCCCCCBr",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CNC(=O)C1=C(O)c2ccccc2C(C)(C#N)C1=O.O=C(O)C(F)(F)F>>CC1(C#N)C(=O)C(C(=O)NCC(=O)O)=C(O)c2ccccc21",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.Cc1cc2c(cc1-c1cc(CO)ccc1OC(F)(F)F)C(C)(C)CCC2(C)C.O=Cc1ccc(F)cc1.[H-].[H][H].[Na+]>>Cc1cc2c(cc1-c1cc(COc3ccc(C=O)cc3)ccc1OC(F)(F)F)C(C)(C)CCC2(C)C",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COc1ccc(C2=NC3(CCCCC3)N(CC(=O)O)C2=O)cc1.ClCCl.O=C(Cl)C(=O)Cl>>COc1ccc(C2=NC3(CCCCC3)N(CC(=O)Cl)C2=O)cc1",
        "output": "56"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(=O)(=O)c1ccc(F)c(C(=O)O)c1F.N#Cc1ccc(N2CCNCC2)cc1>>CS(=O)(=O)c1ccc(F)c(C(=O)N2CCN(c3ccc(C#N)cc3)CC2)c1F",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1CCc2cc(F)cc3c(=O)c(C(=O)O)cn1c23.CN1CCCC1=O.NCCN>>CC1CCc2cc(NCCN)cc3c(=O)c(C(=O)O)cn1c23",
        "output": "572"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccccc1.Fc1ccc(-c2ccc(C3OCCO3)cc2)cc1F.O=CO>>O=Cc1ccc(-c2ccc(F)c(F)c2)cc1",
        "output": "655"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1ccccc1C(C)Oc1cc(-n2cnc3cnc(CO)cc32)sc1C(N)=O.ClCCl>>Cc1ccccc1C(C)Oc1cc(-n2cnc3cnc(COS(C)(=O)=O)cc32)sc1C(N)=O",
        "output": "0"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.O=C(O)c1ccc(Br)cn1.O=C(c1ccc(Cl)cc1)C1CCNCC1>>O=C(c1ccc(Cl)cc1)C1CCN(C(=O)c2ccc(Br)cn2)CC1",
        "output": "605"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.CN1CCC(c2n[nH]c3ccc(N)cc23)CC1.O=S(=O)(Cl)c1ccc(Oc2ccccc2)cc1>>CN1CCC(c2n[nH]c3ccc(NS(=O)(=O)c4ccc(Oc5ccccc5)cc4)cc23)CC1",
        "output": "68"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)[C@@H](N)CCCNC(=O)OC(C)(C)C.Cl.ClCCl.Nc1nc(Cl)cc(SCCC(=O)O)n1.O.O.On1nnc2ccccc21>>COC(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)CCSc1cc(Cl)nc(N)n1",
        "output": "129"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(O)C(F)(F)F.O=C([O-])[O-].O=C1CCC(=O)N1Br.O=S(=O)(O)O.[Na+].[Na+].c1ccc2ncncc2c1>>Brc1ccc2ncncc2c1",
        "output": "4"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.N[C@@H](CC(=O)O)Cc1cc(F)c(F)cc1F>>CC(C)(C)OC(=O)N[C@@H](CC(=O)O)Cc1cc(F)c(F)cc1F",
        "output": "631"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCC(C(=O)OC)c1c(C)nc(N2CCCCC2)nc1Cl.CCN(C(C)C)C(C)C.COCCOC.Cc1ccc(B(O)O)c(C)c1.O.[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCC(C(=O)OC)c1c(C)nc(N2CCCCC2)nc1-c1ccc(C)cc1C",
        "output": "884"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)N1CCNCC1.CCOC(=O)[C@@H]1[C@H](c2ccccc2)[C@H]1c1cccc(Br)c1>>CCOC(=O)[C@@H]1[C@H](c2ccccc2)[C@H]1c1cccc(N2CCN(C(C)C)CC2)c1",
        "output": "294"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.ClCCl.NC(=O)c1cc(Br)c2c(c1)CCC2.O=P(Cl)(Cl)Cl>>N#Cc1cc(Br)c2c(c1)CCC2",
        "output": "374"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1ccc2c(c1)[C@H](Nc1ccccn1)[C@@H](C)[C@H](C1CC1)N2C(C)=O.O.O.[Li+].[OH-]>>CC(=O)N1c2ccc(C(=O)O)cc2[C@H](Nc2ccccn2)[C@@H](C)[C@@H]1C1CC1",
        "output": "5"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O.O=[N+]([O-])c1cc(OCC(F)F)cc(-c2ccc(F)cc2F)c1.[Cl-].[NH4+].[Zn]>>Nc1cc(OCC(F)F)cc(-c2ccc(F)cc2F)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "B.C1CCOC1.N[C@@H](Cc1ccccc1)C(=O)N1CCC(Oc2ccc(F)c(F)c2)CC1>>N[C@@H](Cc1ccccc1)CN1CCC(Oc2ccc(F)c(F)c2)CC1",
        "output": "112"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cc1ccc([N+](=O)[O-])c(C(=O)O)c1.O.O=S(=O)(O)O>>CCOC(=O)c1cc(C)ccc1[N+](=O)[O-]",
        "output": "33"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(CCCCN)CC1CC1.COc1ccc2nc3cc(Cl)ccc3c(Cl)c2c1>>COc1ccc2nc3cc(Cl)ccc3c(NCCCCN(C)CC3CC3)c2c1",
        "output": "78"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CSc1c(F)c(NC(=O)C(C)(C)C)c2c(=O)cc(-c3ccc(NC(=O)C(C)(C)C)c(F)c3)oc2c1F.ClCCl.O=C(OO)c1cccc(Cl)c1.O=S([O-])O.[Na+]>>CS(=O)c1c(F)c(NC(=O)C(C)(C)C)c2c(=O)cc(-c3ccc(NC(=O)C(C)(C)C)c(F)c3)oc2c1F",
        "output": "500"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)OB(c2cnn(CCN3CCOCC3)c2)OC1(C)C.Cc1nc(-c2cn3c(n2)-c2ccc(Br)cc2OCC3)n(C(C)C)n1>>Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(CCN5CCOCC5)c4)cc2OCC3)n(C(C)C)n1",
        "output": "971"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCN(CC1CCCC1)c1ncc(N)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1.CS(=O)(=O)Cl.ClCCl.O>>CCN(CC1CCCC1)c1ncc(NS(C)(=O)=O)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1",
        "output": "812"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.Cn1cncc1C(CCCO)(NS(=O)C(C)(C)C)c1ccc(C#N)c(F)c1>>Cn1cncc1C(CCC=O)(NS(=O)C(C)(C)C)c1ccc(C#N)c(F)c1",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COc1ccc(I)cc1N.Cl.Nc1ncc(Cl)c(Cl)n1.[Na+].[OH-]>>COc1ccc(I)cc1Nc1nc(N)ncc1Cl",
        "output": "352"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.NCc1ccc(-c2nn[nH]n2)cc1.O=C(O)c1cc(F)cnc1Cc1ccc(F)cc1>>O=C(NCc1ccc(-c2nn[nH]n2)cc1)c1cc(F)cnc1Cc1ccc(F)cc1",
        "output": "790"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.CCCCCCCCCCCCCCc1ccc(OCC(O)COC(c2ccccc2)(c2ccccc2)c2ccccc2)c(CC)c1.CN(C)C=O.[H-].[Na+]>>CCCCCCCCCCCCCCc1ccc(OCC(COC(c2ccccc2)(c2ccccc2)c2ccccc2)OCc2ccccc2)c(CC)c1",
        "output": "464"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COC(=O)c1ncc(C)n(-c2cccc(C(F)(F)F)c2)c1=O.O.O=C1CCC(=O)N1Br>>COC(=O)c1nc(Br)c(C)n(-c2cccc(C(F)(F)F)c2)c1=O",
        "output": "665"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)NC(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N#CC1(N)CCSCC1.O=C(O)[C@H](CS(=O)(=O)Cc1ccc(F)cc1)N[C@@H](c1ccc(F)cc1)C(F)(F)F>>N#CC1(NC(=O)[C@H](CS(=O)(=O)Cc2ccc(F)cc2)N[C@@H](c2ccc(F)cc2)C(F)(F)F)CCSCC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)CC(c2ccccc2O)CC(C)(C)C1.CCN(CC)CC.CCOCC.ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.[Cl-].[Na+]>>CC1(C)CC(c2ccccc2OS(=O)(=O)C(F)(F)F)CC(C)(C)C1",
        "output": "731"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1cn(-c2ccc(Br)cc2C#N)cn1.Nc1ncn(Cc2ccc(Cl)cc2Cl)n1>>Cc1cn(-c2ccc(Nc3ncn(Cc4ccc(Cl)cc4Cl)n3)cc2C#N)cn1",
        "output": "970"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2c(N)ncnc2N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN(C)C)CC2)cc1.O.O.[Li+].[OH-]>>CN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccc(C(=O)O)cc2)CC1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)C(CC(C)C)c1cc(O)cc(-c2ccc(C(F)(F)F)cc2)c1.OB(O)c1ccc(F)cc1>>COC(=O)C(CC(C)C)c1cc(Oc2ccc(F)cc2)cc(-c2ccc(C(F)(F)F)cc2)c1",
        "output": "920"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)CN(Cc1cccc(OCCc2nc(-c3ccccc3)oc2C)c1)S(=O)(=O)N1CCCc2ccccc21.O.[Li+].[OH-]>>Cc1oc(-c2ccccc2)nc1CCOc1cccc(CN(CC(=O)O)S(=O)(=O)N2CCCc3ccccc32)c1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CCBr.CN(C)C=O.O.O=C([O-])[O-].Oc1ccc2cccc(/N=C/c3ccccc3)c2c1.[K+].[K+]>>C=CCOc1ccc2cccc(/N=C/c3ccccc3)c2c1",
        "output": "77"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCC.CC[SiH](CC)CC.O=C(O)C(F)(F)F.O=C1Cc2cc(C(=O)CCl)ccc2N1>>O=C1Cc2cc(CCCl)ccc2N1",
        "output": "92"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrBr.C1CCOC1.CCC(=O)c1ccc(C#C[Si](C)(C)C)cc1.O>>CC(Br)C(=O)c1ccc(C#C[Si](C)(C)C)cc1",
        "output": "82"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)c1csc(C2CCN(C(=O)Cn3nc(C(F)(F)F)cc3C)CC2)n1.CO.O.O=Cc1c(F)cccc1F.[Na+].[OH-]>>Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(C(=O)/C=C/c3c(F)cccc3F)cs2)CC1",
        "output": "656"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)OB(c2ccc(C#N)nc2)OC1(C)C.Nc1c2c(nc3c(Br)cccc13)CN(C1CCC1)C2=O>>N#Cc1ccc(-c2cccc3c(N)c4c(nc23)CN(C2CCC2)C4=O)cn1",
        "output": "967"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc(-c2cccc(C=O)c2)ccc1O.NCC[C@@H]1CN(c2ccc3c(c2)NC(=O)CS3)C(=O)O1>>COc1cc(-c2cccc(CNCC[C@@H]3CN(c4ccc5c(c4)NC(=O)CS5)C(=O)O3)c2)ccc1O",
        "output": "468"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)CC1CCN(C(C)(C)C)CC1.Cl.O.[Na+].[OH-]>>CC(C)(C)N1CCC(CC(=O)O)CC1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)c1ccn2c(C(=O)Nc3cccc4c3c(CC)nn4Cc3cccc(C)n3)cnc2c1.Cl.O.[Li+].[OH-]>>CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(C(=O)O)ccn34)c12",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNCCN1.CC#N.O=C(NCCC1CC1)c1ccc(Cl)nn1>>O=C(NCCC1CC1)c1ccc(N2CCNCC2)nn1",
        "output": "406"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.Cl.ClCCl.O=C1NCCCC12CCCNC2.O=S(=O)(Cl)c1cc(F)cc(C(F)(F)F)c1>>O=C1NCCCC12CCCN(S(=O)(=O)c1cc(F)cc(C(F)(F)F)c1)C2",
        "output": "99"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COc1ccc(-c2cc(C#N)c(=O)[nH]c2C)cc1.ClCCl.[Cl-].[NH4+]>>Cc1[nH]c(=O)c(C#N)cc1-c1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CNC(=O)c1cc(C)c(-c2ccc(F)c3c2CC[C@H]3Oc2ccc3c(c2)OC[C@H]3CC(=O)OC)c(C)c1.O.[Li+].[OH-]>>CNC(=O)c1cc(C)c(-c2ccc(F)c3c2CC[C@H]3Oc2ccc3c(c2)OC[C@H]3CC(=O)O)c(C)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)Cc1cccc(Oc2ccc(C)c(C)c2)c1N.O.[Na+].[OH-]>>Cc1ccc(Oc2cccc(CC(=O)O)c2N)cc1C",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cl.Nc1ncc(I)cc1[N+](=O)[O-].O.[Fe]>>Nc1cc(I)cnc1N",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNC1.CN(C)C=O.O=C([O-])[O-].O=Cc1ccccc1F.[K+].[K+]>>O=Cc1ccccc1N1CCCC1",
        "output": "868"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(Br)cc1C(F)(F)F.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>FC(F)(F)c1cc(Br)ccc1CBr",
        "output": "29"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)c1cccc(-n2cccn2)c1Cl.N>>NC(=O)c1cccc(-n2cccn2)c1Cl",
        "output": "67"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cc(C(=O)O)ccc1N.Cl.O.O=N[O-].[I-].[Na+].[Na+]>>COc1cc(C(=O)O)ccc1I",
        "output": "200"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.CCC1(S(=O)(=O)c2cccc(C(F)(F)F)c2)CCOC(COCc2ccccc2)C1.ClCCl>>CCC1(S(=O)(=O)c2cccc(C(F)(F)F)c2)CCOC(CO)C1",
        "output": "178"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCOP(=O)(C#N)OCC.CN(C)C=O.COc1ccccc1N1CCNCC1.O.O=C(O)CC(c1ccccc1)c1ccccc1>>COc1ccccc1N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COc1cc2[nH]ncc2cc1[N+](=O)[O-].ClCCl.O.[Al+3].[Cl-].[Cl-].[Cl-]>>O=[N+]([O-])c1cc2cn[nH]c2cc1O",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCc1ccc(Cl)cc1-n1cccc1C#N.O=C1CCC(=O)N1Br>>CCc1ccc(Cl)cc1-n1cc(Br)cc1C#N",
        "output": "796"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)CSc1cn(S(=O)(=O)c2ccc(Cl)c(Cl)c2)c2ccc(OC)cc12.Cl.[K+].[OH-]>>COc1ccc2c(c1)c(SCC(=O)O)cn2S(=O)(=O)c1ccc(Cl)c(Cl)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(I)cc1.O=C([O-])[O-].O=C1CCCN1.[Cu].[K+].[K+]>>COc1ccc(N2CCCC2=O)cc1",
        "output": "921"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.O=c1ccc2ccccc2n1-c1ccc([N+](=O)[O-])cc1>>Nc1ccc(-n2c(=O)ccc3ccccc32)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)NC(C)C1CCC(C(=O)O)CC1.CC(=O)NC(C)c1ccc(C(=O)O)cc1.CO.CO.Cl.N.[C].[H][H].[Ru]>>COC(=O)C1CCC(C(C)NC(C)=O)CC1",
        "output": "195"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CS(C)=O.N#Cc1ccc(Oc2ccc(C=O)cc2)cc1.O.O=C([O-])[O-].OO.[K+].[K+]>>NC(=O)c1ccc(Oc2ccc(C=O)cc2)cc1",
        "output": "180"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc2[nH]cc(CCNC(C)=O)c2c1.ClCCl.O=S(=O)(Cl)c1ccccc1.O=S(=O)([O-])O.[Na+].[OH-]>>COc1ccc2c(c1)c(CCNC(C)=O)cn2S(=O)(=O)c1ccccc1",
        "output": "648"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)OC(=O)OC(C)(C)C.CCN(CC)CC.CO.Cc1cccc(C(N)CCC(=O)O)c1.O=C([O-])O.[Na+]>>Cc1cccc(C(CCC(=O)O)NC(=O)OC(C)(C)C)c1",
        "output": "686"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)C(C(=O)NC(Cc1ccc(O)c(C(C)(C)C)c1)c1ncno1)N(C)C(=O)C(Cc1ccc(F)cc1)NC(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CC(C)C(C(=O)NC(Cc1ccc(O)c(C(C)(C)C)c1)c1ncno1)N(C)C(=O)C(N)Cc1ccc(F)cc1",
        "output": "431"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN.CCOC(C)=O.CO.COc1nc(Cl)ncc1Br>>CCNc1ncc(Br)c(OC)n1",
        "output": "544"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CNCCCC(C(N)=O)(c1ccccc1)c1ccccc1.Clc1ccc(CCBr)cc1.O=C([O-])[O-].[K+].[K+]>>CN(CCCC(C(N)=O)(c1ccccc1)c1ccccc1)CCc1ccc(Cl)cc1",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.CC(C)Oc1ccc(C(C)O)nc1.CC1(C)CCCC(C)(C)N1[O].O=c1n(Cl)c(=O)n(Cl)c(=O)n1Cl>>CC(=O)c1ccc(OC(C)C)cn1",
        "output": "456"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.C[S-].O=C1c2ccccc2C(=O)N1CCCCBr.[Na+]>>CSCCCCN1C(=O)c2ccccc2C1=O",
        "output": "185"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(N)(C#N)COc1cc(C#N)ccc1Oc1ccc(Cl)cc1Cl.CCN(C(C)C)C(C)C.ClCCl.O=C(Cl)c1ccc(OC(F)(F)F)cc1>>CC(C#N)(COc1cc(C#N)ccc1Oc1ccc(Cl)cc1Cl)NC(=O)c1ccc(OC(F)(F)F)cc1",
        "output": "271"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1cccc(C(=O)O)c1.Cl.Nc1cccc(C(F)(F)F)c1.On1nnc2ccccc21>>Cc1cccc(C(=O)Nc2cccc(C(F)(F)F)c2)c1",
        "output": "50"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1nc2c(N)nc3cc(OCCOCCNC(=O)OC(C)(C)C)ccc3c2s1.CCO.Cl>>CCCc1nc2c(N)nc3cc(OCCOCCN)ccc3c2s1",
        "output": "538"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)[C@@H]1c2ccc(F)cc2CC[C@@]1(O)CCO.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCC[C@]2(O)CCc3cc(F)ccc3[C@H]2C(C)C)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCOCCCC.CCOCC.C[Mg]Br.O=Cc1ccc(F)c(-c2ccc3nc(-c4ccc(Cl)cc4)cn3c2)c1.[Cl-].[NH4+]>>CC(O)c1ccc(F)c(-c2ccc3nc(-c4ccc(Cl)cc4)cn3c2)c1",
        "output": "787"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrBr.CC(=O)c1cccc(F)c1.ClC(Cl)Cl>>O=C(CBr)c1cccc(F)c1",
        "output": "173"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCO[C@@H](C)[C@@H](C)OCc1ccccc1.CCO.Cl.[C].[Pd]>>CCCCO[C@@H](C)[C@@H](C)O",
        "output": "178"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)C1=C(C(=O)N2CCC[C@H]2C(=O)O)SC2=N[C@@](C)(c3ccc(Cl)cc3)[C@@H](c3ccc(Cl)cc3)N21.CN(C)[C@@H]1CCNC1>>CC(C)C1=C(C(=O)N2CCC[C@H]2C(=O)N2CC[C@@H](N(C)C)C2)SC2=N[C@@](C)(c3ccc(Cl)cc3)[C@@H](c3ccc(Cl)cc3)N21",
        "output": "685"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2[nH]c3ccccc3c2c1.Cl.O.O.O.[Li]O>>O=C(O)c1ccc2[nH]c3ccccc3c2c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(NC(=O)OC(C)(C)C)CN(c2nc3ncc(Br)cc3n3cnnc23)C1.ClCCl.O=C(O)C(F)(F)F>>CC1(N)CN(c2nc3ncc(Br)cc3n3cnnc23)C1",
        "output": "538"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CO.O=C(O)c1ccc([N+](=O)[O-])cc1F.[Pd]>>Nc1ccc(C(=O)O)c(F)c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.O=C(O)Cc1ccc(F)c2ccccc12.O=S(Cl)Cl>>O=C1Cc2ccc(F)c3cccc1c23",
        "output": "274"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(=O)[C@H]1[C@@H]2Cc3cc(OCc4cc(-c5ccc(O)cc5F)c(C(F)(F)F)cc4F)ncc3[C@@H]21.ClCCl.O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)[C@H]1[C@@H]2Cc3cc(OCc4cc(-c5ccc(OS(=O)(=O)C(F)(F)F)cc5F)c(C(F)(F)F)cc4F)ncc3[C@@H]21",
        "output": "843"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN1CC(CCCl)N(C)c2ccccc2C1=O.CCO.CNC>>CCN1CC(CCN(C)C)N(C)c2ccccc2C1=O",
        "output": "138"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(COC(C(=O)OCCN2CCOCC2)C(C)(C)COS(=O)(=O)CCCCl)cc1.CS(C)=O.[N-]=[N+]=[N-].[Na+]>>COc1ccc(COC(C(=O)OCCN2CCOCC2)C(C)(C)COS(=O)(=O)CCCN=[N+]=[N-])cc1",
        "output": "243"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.FCCBr.O=C([O-])[O-].O=[N+]([O-])c1cn[nH]c1.[K+].[K+]>>O=[N+]([O-])c1cnn(CCF)c1",
        "output": "577"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(=O)c1cccc(Nc2ccccc2)c1.O.[Na+].[OH-]>>O=C(O)c1cccc(Nc2ccccc2)c1",
        "output": "5"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.ClCCl.O=Cc1c(Cl)[nH]c2ncccc12.OB(O)c1ccccc1.c1ccncc1>>O=Cc1c(Cl)n(-c2ccccc2)c2ncccc12",
        "output": "962"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(CC)NC(=O)Nc1ccc(Oc2ccc(NC(=O)c3ccc(OC4CCNCC4)cc3)cc2)c(OC)c1.CCCBr.CCN(C(C)C)C(C)C.CN(C)C=O>>CCCN1CCC(Oc2ccc(C(=O)Nc3ccc(Oc4ccc(NC(=O)NC(CC)CC)cc4OC)cc3)cc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCOC(C)=O.CSc1nc(C)c(C#N)c(N[C@@H](C)c2nc3ccn(C)c3cc2-c2ccnn2C)n1.O.O=S([O-])OO.[K+]>>Cc1nc(S(C)(=O)=O)nc(N[C@@H](C)c2nc3ccn(C)c3cc2-c2ccnn2C)c1C#N",
        "output": "840"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.CC(c1ccc2[nH]c(C(=O)Nc3cc(F)cc(F)c3)cc2c1)C1CCNC1>>CC(=O)N1CCC(C(C)c2ccc3[nH]c(C(=O)Nc4cc(F)cc(F)c4)cc3c2)C1",
        "output": "125"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)CNCCc1c[nH]c2c(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)cccc12.CO.O.[Na+].[OH-]>>CC(C)Oc1ccc(-c2nc(-c3cccc4c(CCNCC(=O)O)c[nH]c34)no2)cc1Cl",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CNCCNC.Cc1ccccc1.FC(F)(F)c1cccc(Br)c1.O.[C-]#N.[Cu]I.[NH4+].[Na+].[OH-]>>N#Cc1cccc(C(F)(F)F)c1",
        "output": "65"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=CCBr.CC(C)(C)[O-].COc1ccc(COCC[C@H](O)COC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.[K+]>>C=CCO[C@@H](CCOCc1ccc(OC)cc1)COC(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "120"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COc1cc2c(NCc3sc(C)nc3C)c([N+](=O)[O-])cnc2cc1-c1c(C)noc1C.Cl.Cl[Sn]Cl.O.O.O.[Na+].[OH-]>>COc1cc2c(NCc3sc(C)nc3C)c(N)cnc2cc1-c1c(C)noc1C",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1=COCCC1.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.O.O=C([O-])[O-].OCCn1nnnc1Br.[Na+].[Na+].c1cc[nH+]cc1>>Brc1nnnn1CCOC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.ClCCl.O=c1c(-c2cccc(Cl)c2)cc2c(n1CC1CCC1)CCNC2>>CS(=O)(=O)N1CCc2c(cc(-c3cccc(Cl)c3)c(=O)n2CC2CCC2)C1",
        "output": "584"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.Cc1cc(Cl)ccn1.O=C(Nc1ccc(Cl)cn1)c1ccccc1NCC1CCNCC1>>Cc1cc(N2CCC(CNc3ccccc3C(=O)Nc3ccc(Cl)cn3)CC2)ccn1",
        "output": "398"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(Cl)OC(=O)Cl.COCCOCCOCCOCCOCCOCCOCCOCCO.ClCCl.c1ccncc1>>COCCOCCOCCOCCOCCOCCOCCOCCOC(=O)OC(C)Cl",
        "output": "144"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1CC/C=C/c1cccc([N+](=O)[O-])c1>>NCC/C=C/c1cccc([N+](=O)[O-])c1",
        "output": "242"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCBr.CN(C)C=O.O.c1ccc2c(c1)CC1CNCCCN21>>CCN1CCCN2c3ccccc3CC2C1",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.Cc1nc(Cl)cc2c(Cl)c(C(N)=O)cnc12.Nc1cccc2c1CCO2>>Cc1nc(Cl)cc2c(Nc3cccc4c3CCO4)c(C(N)=O)cnc12",
        "output": "957"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.CCN(C(C)C)C(C)C.CO.Cn1cnc2c(C#N)nc(-c3ccc(OCCC4CCN(C(=O)CCl)CC4)c(C(F)(F)F)c3)cc21>>Cn1cnc2c(C#N)nc(-c3ccc(OCCC4CCN(C(=O)CN5CCCC5)CC4)c(C(F)(F)F)c3)cc21",
        "output": "340"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)C=O.CN1CCN(S(=O)(=O)c2c(Cl)ccc(Nc3c(Cl)c(=O)c3=O)c2O)CC1.ClCCl.Nc1ccc(F)cc1Cl.c1ccc(-c2ccccc2)cc1>>CN1CCN(S(=O)(=O)c2c(Cl)ccc(Nc3c(Nc4ccc(F)cc4Cl)c(=O)c3=O)c2O)CC1",
        "output": "510"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)n1ccc2cc(C=O)ccc21.CC(C)C[C@@H](N)C(N)=O.CO.ClCCCl.ClCCl.O=C([O-])O.[Na+].[Na+]>>CC(C)(C)OC(=O)n1ccc2cc(CO)ccc21",
        "output": "356"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCOc1cccc(CO)c1.CN(C)C=O.ClCCl.O=C([O-])O.O=S(Cl)Cl.[Na+]>>C=CCOc1cccc(CCl)c1",
        "output": "81"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.Cc1[nH]cc(OCc2ccccc2)c(=O)c1Cl.O.O=C([O-])[O-].[K+].[K+]>>Cc1c(Cl)c(=O)c(OCc2ccccc2)cn1C",
        "output": "191"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(C(=O)O)c2nc(-c3cccs3)[nH]c12.Cc1ccccc1.NCCc1ncc[nH]1.O=S(Cl)Cl.c1ccncc1>>COc1ccc(C(=O)NCCc2ncc[nH]2)c2nc(-c3cccs3)[nH]c12",
        "output": "674"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.ClCCl.Nc1ccc2ncccc2c1Br>>CC(C)(C)OC(=O)Nc1ccc2ncccc2c1Br",
        "output": "735"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NC[C@H]1CN(c2cc(F)c(C3=CCN(Cc4ccccc4)CC3)c(F)c2)C(=O)O1.[N-]=[N+]=NC[C@H]1CN(c2ccc(C3=CCN(Cc4ccccc4)CC3)c(F)c2)C(=O)O1>>NC[C@H]1CN(c2ccc(C3=CCN(Cc4ccccc4)CC3)c(F)c2)C(=O)O1",
        "output": "89"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCOC(C)=O.CN1CCNCC1.Clc1ccc(Nc2nc3cccc(-c4ccc(CN5CCOCC5)cc4)n3n2)cc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>CN1CCN(c2ccc(Nc3nc4cccc(-c5ccc(CN6CCOCC6)cc5)n4n3)cc2)CC1",
        "output": "105"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C)CCCC(=O)C1.CO.[BH4-].[Na+]>>CC1(C)CCCC(O)C1",
        "output": "91"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)c1ccc(-c2nc(CCO)cs2)cc1.CCOC(=O)C(Cc1ccc(O)c(F)c1)OCC.CCOC(=O)N=NC(=O)OCC.CCOC(Cc1ccc(OCc2csc(-c3ccc(C(C)C)cc3)n2)c(C)c1)C(=O)O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)C(Cc1ccc(OCCc2csc(-c3ccc(C(C)C)cc3)n2)c(F)c1)OCC",
        "output": "478"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(CO)C(=O)O.CCN(C(C)C)C(C)C.CCOC(=O)c1c(Cl)ccc(CN)c1F.CCOC(C)=O.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F>>CCOC(=O)c1c(Cl)ccc(CNC(=O)C(C)(C)CO)c1F",
        "output": "599"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CCOC(C)=O.N#Cc1ncc([N+](=O)[O-])cc1F.[Fe]>>N#Cc1ncc(N)cc1F",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[C@@H]1COC(=O)N1c1ccc(C(=O)O)cc1.Cc1ccc(C(=O)C2CCNCC2)c(C)c1.Cl>>Cc1ccc(C(=O)C2CCN(C(=O)c3ccc(N4C(=O)OC[C@H]4C)cc3)CC2)c(C)c1",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccccc1OCCCCl.CC(C)(C)N.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1ccccc1OCCCNC(C)(C)C",
        "output": "279"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1cc(F)cc(F)c1.O=C(O)Cc1ccccc1Br>>O=C(O)Cc1ccccc1Nc1cc(F)cc(F)c1",
        "output": "405"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.NC(=O)[C@@H]1C[C@@H]2C[C@@H]2N1.O=C(N[C@H](C(=O)O)C12CC3CC(CC(O)(C3)C1)C2)OCc1ccccc1.On1nnc2ccccc21>>NC(=O)[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](NC(=O)OCc1ccccc1)C12CC3CC(CC(O)(C3)C1)C2",
        "output": "297"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(O)c1.CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.c1c[nH]cn1>>CC(C)(C)OC(=O)Nc1cccc(O[Si](C)(C)C(C)(C)C)c1",
        "output": "746"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)N=C=O.CCCCCC.Nc1ccc(Cl)cc1C(=O)c1ccccc1>>CC(C)NC(=O)Nc1ccc(Cl)cc1C(=O)c1ccccc1",
        "output": "176"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc(-n2cc(-c3cccnc3)nn2)o1.Cl.O.[K+].[OH-]>>O=C(O)c1ccc(-n2cc(-c3cccnc3)nn2)o1",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2ccc(F)cc2)C(O)C1.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.O=C(Cl)c1ccc2ccccc2c1>>CC(C)(C)OC(=O)N1CCC(c2ccc(F)cc2)C(OC(=O)c2ccc3ccccc3c2)C1",
        "output": "51"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cccc(NC(=O)OC(C)(C)C)n1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(C)OC(=O)Nc1cccc(CO)n1",
        "output": "711"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=C1c2ccc(Cl)cc2SCC1Br.[BH4-].[Na+]>>OC1c2ccc(Cl)cc2SCC1Br",
        "output": "24"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1CN(c2ccc(C#N)cn2)CCN1.N#CCCCC(=O)O>>CC1CN(c2ccc(C#N)cn2)CCN1C(=O)CCCC#N",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCCCO.CCN(CC)CC.CO.C[C@@H](O)[C@@H](C)Nc1nc(Nc2ccc(N)cc2)ncc1Br.Cl.Clc1ncccn1>>C[C@@H](O)[C@@H](C)Nc1nc(Nc2ccc(Nc3ncccn3)cc2)ncc1Br",
        "output": "808"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)Cl.CCSc1ncc(C(=O)O)s1.NCCC1C2CCC1CC2>>CCSc1ncc(C(=O)NCCC2C3CCC2CC3)s1",
        "output": "534"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COCCOC.Cc1cccc(Oc2cccc(C=O)c2)c1.Cl.[BH4-].[Na+]>>Cc1cccc(Oc2cccc(CO)c2)c1",
        "output": "356"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(N)c1nc2ncccn2c1-c1ccccn1.CCCCO.CCN(C(C)C)C(C)C.N#Cc1c(N)ncnc1Cl>>CC(Nc1ncnc(N)c1C#N)c1nc2ncccn2c1-c1ccccn1",
        "output": "110"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.NC1CCN(CCc2c[nH]c3ccccc23)CC1.O>>Cc1ccc(S(=O)(=O)NC2CCN(CCc3c[nH]c4ccccc34)CC2)cc1",
        "output": "43"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)c1ccc(N)cc1.COc1cn(C(CC2(C(F)(F)F)CCC2)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1C#N>>COc1cn(C(CC2(C(F)(F)F)CCC2)C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N",
        "output": "710"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(CC(=O)OC(C)(C)C)N(c1ccccc1)S(=O)(=O)c1ccccn1.O=C(O)C(F)(F)F>>CC(CC(=O)O)N(c1ccccc1)S(=O)(=O)c1ccccn1",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=C[C@@H]1[C@H](CO)C[C@H](C(=O)OC(C)(C)C)N1Cc1ccccc1.CC(=O)OC(C)=O.CN(C)c1ccncc1.c1ccncc1>>C=C[C@@H]1[C@H](COC(C)=O)C[C@H](C(=O)OC(C)(C)C)N1Cc1ccccc1",
        "output": "254"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1c(C2=NN(Cc3ccc(Cl)cc3)S(=O)(=O)c3ccccc32)c2cc(F)ccc2n1CC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>Cc1c(C2=NN(Cc3ccc(Cl)cc3)S(=O)(=O)c3ccccc32)c2cc(F)ccc2n1CC(=O)O",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)Nc1c(F)cccc1C(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.Cl.NC1CCN(Cc2ccccc2)CC1.On1nnc2ccccc21>>CC(C)(C)OC(=O)Nc1c(F)cccc1C(=O)NC1CCN(Cc2ccccc2)CC1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCS.COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2ccc(OC3CCCCC3N3CCCC3)cc2)cc1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(c1ccc(OC2CCCCC2N2CCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12",
        "output": "20"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCCCI.N#CC1CCCCNC1>>CCCCN1CCCCC(C#N)C1",
        "output": "184"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCCCCCCCCCO[C@H]1CCCO[C@H]1COCc1ccccc1.CCO.CO.[Pd]>>CCCCCCCCCCCCCCCCO[C@H]1CCCO[C@H]1CO",
        "output": "178"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CI.CN(C)C=O.O=C(/C=C/c1ccc(Cl)cc1Cl)c1ccc(OCC(O)(Cn2cncn2)c2ccc(F)cc2F)cc1.[H-].[Na+]>>COC(COc1ccc(C(=O)/C=C/c2ccc(Cl)cc2Cl)cc1)(Cn1cncn1)c1ccc(F)cc1F",
        "output": "140"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C1COCCN1.CCN(C(C)C)C(C)C.O=C(CBr)c1ccc([N+](=O)[O-])cc1>>O=C(CN1CCOCC1)c1ccc([N+](=O)[O-])cc1",
        "output": "413"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1cnc2nc(COc3ccccn3)cn2c1.OCc1cc(C(F)(F)F)ccc1B(O)O>>OCc1cc(C(F)(F)F)ccc1-c1cnc2nc(COc3ccccn3)cn2c1",
        "output": "871"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNCC1.C1CCOC1.C1CN[C@H](CN2CCCC2)C1.CCN(CC)CC.Cc1c(-c2ccc(C(=O)O)s2)noc1C(F)(F)F>>Cc1c(-c2ccc(C(=O)N3CCC[C@H]3CN3CCCC3)s2)noc1C(F)(F)F",
        "output": "857"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(C)N.CCO.Cc1cc([N+](=O)[O-])c(Cl)c([N+](=O)[O-])c1C>>CCC(C)Nc1c([N+](=O)[O-])cc(C)c(C)c1[N+](=O)[O-]",
        "output": "304"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C1CCN(c2cccc3c2CC(=CCCN2CCC(O)(c4ccc(Cl)cc4)CC2)c2ccc(C(N)=O)nc2O3)CC1.CO.[Li+].[OH-]>>NC(=O)c1ccc2c(n1)Oc1cccc(N3CCC(C(=O)O)CC3)c1CC2=CCCN1CCC(O)(c2ccc(Cl)cc2)CC1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1c2ccccc2S(=O)(=O)c2cc(CO)ccc21.ClC(Cl)Cl.O=S(Cl)Cl>>CN1c2ccccc2S(=O)(=O)c2cc(CCl)ccc21",
        "output": "81"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CCc1c[nH]nc1OCC.CN(C)C=O.COc1cc(CCl)ccc1OCc1ccccc1.O.[H-].[Na+]>>CCOC(=O)CCc1cn(Cc2ccc(OCc3ccccc3)c(OC)c2)nc1OCC",
        "output": "842"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(CC)CC.COC(=O)C1CCN(C(=O)OC)C(Cc2cccc(F)c2)C1.COC(C)(C)C.O.[Br-].[Li+]>>COC(=O)N1CCC(C(=O)O)CC1Cc1cccc(F)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.ClCCl.N#Cc1cccc(COCCO)c1>>CS(=O)(=O)OCCOCc1cccc(C#N)c1",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CCCC1=O.Fc1ccc(F)c(F)n1.O=C([O-])[O-].OCc1ccccc1.[K+].[K+]>>Fc1ccc(F)c(OCc2ccccc2)n1",
        "output": "541"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Cl.N#Cc1c(F)cccc1OC(F)F.NO.O.O=C([O-])[O-].[Na+].[Na+]>>NC(=NO)c1c(F)cccc1OC(F)F",
        "output": "400"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cccc2cc(C(=O)O)c(=O)oc12.F[P-](F)(F)(F)(F)F.Nc1cccc(-c2cn[nH]c2)c1>>COc1cccc2cc(C(=O)Nc3cccc(-c4cn[nH]c4)c3)c(=O)oc12",
        "output": "799"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccccc1.N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1SC(F)(F)F.O=C(Cl)CCCl.[Cl-].[Cl-].[Zn+2]>>N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(NC(=O)CCCl)c1SC(F)(F)F",
        "output": "527"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COC(=O)Cc1ccc(C2CC2)c(O[Si](C)(C)C(C)(C)C)c1.Cl.[F-]>>COC(=O)Cc1ccc(C2CC2)c(O)c1",
        "output": "754"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1ccc(Cl)nc1.N#Cc1ccc(Oc2ccc3c(c2)CCC(C2CCC2)NC3)nc1.Oc1ccc2c(c1)CCN(C1CCC1)CC2>>CC(=O)c1ccc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)nc1",
        "output": "516"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)NC(C)C.CCCCCC.Cl.ClCCl.O.O=C1CCC(=O)N1Br.Oc1cccc2c1CCCC2>>Oc1c(Br)ccc2c1CCCC2",
        "output": "4"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCCCC1Cn1cnc(C(=O)N2CCN(Cc3ccccc3)C[C@H]2Cc2ccccc2)c1-c1ccccc1.ClCCl.O=C(O)C(F)(F)F>>O=C(c1ncn(CC2CCCCN2)c1-c1ccccc1)N1CCN(Cc2ccccc2)C[C@H]1Cc1ccccc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1c(Br)cccc1-n1c(=O)[nH]c2c(Cl)cccc2c1=O.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1c(B2OC(C)(C)C(C)(C)O2)cccc1-n1c(=O)[nH]c2c(Cl)cccc2c1=O",
        "output": "942"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)Cc1cc2ccc(F)cc2c(-c2ccc(S(=O)(=O)c3c(F)cccc3F)cc2)c1C.O.O.[Li+].[OH-]>>Cc1c(CC(=O)O)cc2ccc(F)cc2c1-c1ccc(S(=O)(=O)c2c(F)cccc2F)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)CC(=O)O.Cl.FC(F)c1nc2ccccc2n1-c1cc(N2CCOCC2)nc(NC2CCNCC2)n1.O.On1nnc2ccccc21>>CN(C)CC(=O)N1CCC(Nc2nc(N3CCOCC3)cc(-n3c(C(F)F)nc4ccccc43)n2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CN(C)C=O.C[C@@H](O)CC#C[Si](C)(C)C.c1c[nH]cn1>>C[C@H](CC#C[Si](C)(C)C)O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C",
        "output": "602"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)/C=C/C=C(\\c1ccc(OC)cc1)C1CCCCC1.[Na+].[OH-]>>COc1ccc(/C(=C\\C=C\\C(=O)O)C2CCCCC2)cc1",
        "output": "58"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN.O=C(Cl)c1cc(Cl)ccc1Cl>>CCNC(=O)c1cc(Cl)ccc1Cl",
        "output": "271"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CN)c1.N#Cc1ccc(Cl)nn1>>Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ccc(C#N)nn2)c1",
        "output": "241"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)CCO.COc1cc2nc(Cl)nc(N)c2cc1OC.CSc1nnc(C(=O)C2CCNCC2)o1>>COc1cc2nc(N3CCC(C(=O)c4nnc(SC)o4)CC3)nc(N)c2cc1OC",
        "output": "36"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.O=[N+]([O-])c1ccc(-c2ncon2)cc1.[Pd]>>Nc1ccc(-c2ncon2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CO.COC(=O)c1cc(C)c2c(c1)S(=O)(=O)Cc1cc(NCCCl)cc(Cl)c1O2.NC1CC1.[I-]>>COC(=O)c1cc(C)c2c(c1)S(=O)(=O)Cc1cc(NCCNC3CC3)cc(Cl)c1O2",
        "output": "279"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc(F)ccc1-c1ccc(OC(C)=O)c(C(=O)O)c1.Cl.O=P(Cl)(Cl)Cl.Oc1ccccc1>>COc1cc(F)ccc1-c1ccc(OC(C)=O)c(C(=O)Oc2ccccc2)c1",
        "output": "355"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cc2cc(O)cc([N+](=O)[O-])c2[nH]1.CN(C)C=O.Cc1ccc(S(=O)(=O)OCCCS(C)(=O)=O)cc1.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cc2cc(OCCCS(C)(=O)=O)cc([N+](=O)[O-])c2[nH]1",
        "output": "438"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "N[C@H]1CCN(CCc2ccc(F)cc2)C1.O=C(O)Cc1ccccc1C1CCCC1>>O=C(Cc1ccccc1C1CCCC1)N[C@H]1CCN(CCc2ccc(F)cc2)C1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1cnn2c(C(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12.CC(C)(CO)NS(=O)(=O)c1cccc(Br)c1>>CC(C)(CO)NS(=O)(=O)c1cccc(C#Cc2cnn3c(C(F)F)cc(-c4ccc(C(F)(F)F)cc4)nc23)c1",
        "output": "659"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NNc1ccc(F)cc1F.O=Cc1cc(O)c(O)cc1O>>Oc1cc(O)c(C=NNc2ccc(F)cc2F)cc1O",
        "output": "167"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(CC)CC.NCc1ccccn1.O.O=C(Cl)CCCCBr>>O=C(CCCCBr)NCc1ccccn1",
        "output": "45"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.Cc1ccc(Cl)c(O)c1F.c1ccncc1>>CC(=O)Oc1c(Cl)ccc(C)c1F",
        "output": "46"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCC.CCCCP(CCCC)CCCC.CSCCCO.Cc1cc(O)cc(C)c1Br.Cc1ccccc1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CSCCCOc1cc(C)c(Br)c(C)c1",
        "output": "550"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.NCCc1ccco1>>CC(=O)NCCc1ccco1",
        "output": "339"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CCO.CCN(CC)CC.CN(C)C=O.N#Cc1cc(I)cc(-c2nc(-c3ccccn3)no2)c1.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>N#Cc1cc(C#CCO)cc(-c2nc(-c3ccccn3)no2)c1",
        "output": "664"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc2c(c1OC)CCC(N)C2.ClCCl.O=C(O)CCCCC(=O)NCCc1ccccc1.O=C(n1ccnc1)n1ccnc1>>COc1ccc2c(c1OC)CCC(NC(=O)CCCCC(=O)NCCc1ccccc1)C2",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.NC(=O)c1ccc([N+](=O)[O-])c(Oc2ccc(F)cc2F)c1.O.[Cl-].[Fe].[NH4+]>>NC(=O)c1ccc(N)c(Oc2ccc(F)cc2F)c1",
        "output": "28"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN=C=NCCCN(C)C.COCCOCCOC.Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)O)cc2cn(COCC[Si](C)(C)C)nc12.Cl.NC(=NO)c1ccc(F)cc1>>Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2nc(-c3ccc(F)cc3)no2)cc2cn(COCC[Si](C)(C)C)nc12",
        "output": "926"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCC(Br)C(=O)OCC.CN(C)C=O.O.O=C([O-])[O-].Oc1ccccc1Br.[I-].[K+].[K+].[K+]>>CCCC(Oc1ccccc1Br)C(=O)OCC",
        "output": "455"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.Cc1ccccc1.NCCCC(=O)O.O=C1OC(=O)c2ccccc21>>O=C(O)CCCN1C(=O)c2ccccc2C1=O",
        "output": "341"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(=O)Cl.COc1ccc(OCC2CC2)c(-c2ccnc3c(C(=O)NC4CCNCC4)c(C)[nH]c23)c1.Cl>>CCC(=O)N1CCC(NC(=O)c2c(C)[nH]c3c(-c4cc(OC)ccc4OCC4CC4)ccnc23)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)CCCC(=O)OCc1ccccc1.CO.[H][H].[Pd]>>CN(C)CCCC(=O)O",
        "output": "186"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCNC(C#N)C1.ClCCl.O.O=CCOCCO.O=CO.[BH3-]C#N.[Na+]>>CC(C)(C)OC(=O)N1CCN(CCOCCO)C(C#N)C1",
        "output": "484"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)[C@@H](C(=O)OCc1ccccc1)N(Cc1ccc(-c2ccccc2C#N)cc1)C(=O)CCC1(C)OCCO1.Cl>>CC(=O)CCC(=O)N(Cc1ccc(-c2ccccc2C#N)cc1)[C@H](C(=O)OCc1ccccc1)C(C)C",
        "output": "251"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.N#CC1(C#N)C2C=CC(C2)C1(Cl)Cl.[H][H].[Pt]>>N#CC1(C#N)C2CCC(C2)C1(Cl)Cl",
        "output": "143"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(CC)(c1ccc(OCC(=O)NOCc2ccccc2)c(C)c1)c1ccc(OCC(=O)C(C)(C)C)c(C)c1.CCOC(C)=O.[Pd]>>CCC(CC)(c1ccc(OCC(=O)NO)c(C)c1)c1ccc(OCC(=O)C(C)(C)C)c(C)c1",
        "output": "707"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CS(C)=O.NCCc1ccccn1.Nc1nc(Cl)ccc1C(=O)NCc1ccc(Oc2ccccc2)s1.O.O=C(Cc1ccccc1)NCN[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O>>Nc1nc(NCCc2ccccn2)ccc1C(=O)NCc1ccc(Oc2ccccc2)s1",
        "output": "70"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.CC(O)(CO)c1cncc(OCC#Cc2ccccc2)c1>>CC1(C)OCC(C)(c2cncc(OCC#Cc3ccccc3)c2)O1",
        "output": "265"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1nc2c(OC3CCOc4ccccc43)cc(C(=O)O)cc2n1C.O[C@@H]1CCNC1>>Cc1nc2c(OC3CCOc4ccccc43)cc(C(=O)N3CC[C@@H](O)C3)cc2n1C",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=C(Cc1cccs1)Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccc4c(c3)CC(NC(=O)C(F)(F)F)C4)n2)c1.[Li+].[OH-]>>NC1Cc2ccc(Nc3nccc(-c4c(-c5cccc(NC(=O)Cc6cccs6)c5)nn5ccccc45)n3)cc2C1",
        "output": "805"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cc1c(O)cc(C(=O)O)cc1[N+](=O)[O-].O=S(Cl)Cl>>COC(=O)c1cc(O)c(C)c([N+](=O)[O-])c1",
        "output": "33"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(O)CCO.CCOC(C)=O.ClCCl.O=S(=O)(Cl)c1ccccc1C(F)(F)F>>CC(C)(O)CCOS(=O)(=O)c1ccccc1C(F)(F)F",
        "output": "197"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.ClCCl.O=S(=O)(Cl)c1ccc(Cl)nc1.O=S1(=O)CCNCC1>>O=S1(=O)CCN(S(=O)(=O)c2ccc(Cl)nc2)CC1",
        "output": "169"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.FC(F)Oc1cccnc1Cl.[Na]>>COc1ncccc1OC(F)F",
        "output": "433"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CN.O.O=C(CCl)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1>>CNCC(=O)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1",
        "output": "330"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1nn(C2CCCCO2)cc1NC(=O)c1ccccc1.Cl.O.[Na+].[OH-]>>O=C(Nc1cn(C2CCCCO2)nc1C(=O)O)c1ccccc1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.C1CCOC1.O=[N+]([O-])c1cccc(CBr)c1>>O=[N+]([O-])c1cccc(CN2CCCC2)c1",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1noc(-c2ccc(Br)cc2)c1CN1CCC(c2ccccc2)C1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4CN4CCC(c5ccccc5)C4)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NCC1CCC(CN[C@H](C(=O)OC2CCCC2)c2ccccc2)CC1.ClCCl.O=C(O)C(F)(F)F>>NCC1CCC(CN[C@H](C(=O)OC2CCCC2)c2ccccc2)CC1",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1NC(=O)N(C)c1cc(Cl)ncn1.Cc1ccc(S(=O)(=O)O)cc1.Nc1ccc(N2CCOCC2)cc1>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1NC(=O)N(C)c1cc(Nc2ccc(N3CCOCC3)cc2)ncn1",
        "output": "161"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOCC.Cc1cccc(N)n1>>Cc1cccc(NC(=O)OC(C)(C)C)n1",
        "output": "849"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)Cn1nc(-c2ccccc2OC(F)(F)F)n(C2CC2)c1=O.[Li+].[OH-]>>O=C(O)Cn1nc(-c2ccccc2OC(F)(F)F)n(C2CC2)c1=O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Nc1nc(C(=O)N2Cc3ccccc3C2)c2cc(-c3cc(F)c(F)cc3CO)ccc2n1.O=S(Cl)Cl>>Nc1nc(C(=O)N2Cc3ccccc3C2)c2cc(-c3cc(F)c(F)cc3CCl)ccc2n1",
        "output": "81"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(C)=O.Cc1c(CC#N)cccc1[N+](=O)[O-].[Pd]>>Cc1c(N)cccc1CC#N",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)C[Al]CC(C)C.CCOC(=O)CCc1cccc2c1B(O)OC2>>OCCCc1cccc2c1B(O)OC2",
        "output": "225"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(C)C[Al+]CC(C)C.COC(=O)CCCN1CCC[C@H]1COc1ccc(Cc2ccccc2)cc1.Cc1ccccc1.[H-]>>OCCCCN1CCC[C@H]1COc1ccc(Cc2ccccc2)cc1",
        "output": "343"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCc1oc2ccccc2c1C(=O)c1cc(C)c(OC)c(C)c1.CN(C)C=O>>CCc1oc2ccccc2c1C(=O)c1cc(C)c(O)c(C)c1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.C1COCCO1.CCOC(C)=O.C[C@H]1Cc2nn(C)c(-c3cccs3)c2CN1C(=O)OC(C)(C)C.Cl>>C[C@H]1Cc2nn(C)c(-c3cccs3)c2CN1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(C#N)[n+]([O-])c1.O=P(Cl)(Cl)Cl>>Cc1ccc(C#N)nc1Cl",
        "output": "2"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.F[P-](F)(F)(F)(F)F.Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1.O.O=C(O)C1CSC(c2ccc(F)cc2)=N1>>O=C(Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1)C1CSC(c2ccc(F)cc2)=N1",
        "output": "563"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2ccc(F)cc2F)CN1.O=C(O)Cn1cncn1>>O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2ccc(F)cc2F)CN1C(=O)Cn1cncn1",
        "output": "297"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCN(C(C)C)C(C)C.ClCCl.OCCCCO>>CC(C)(C)[Si](OCCCCO)(c1ccccc1)c1ccccc1",
        "output": "602"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCCCCBr.C1CCCCC1.CC(=O)N(C)C.O.O=C1CCc2ccc(O)cc2N1.[Na+].[OH-]>>O=C1CCc2ccc(OCCCCBr)cc2N1",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Cn1nc(-c2c(F)cccc2Cl)nc1-c1ccc(CBr)c(Cl)c1.O.O=C([O-])[O-].Oc1ccc(C(F)(F)F)cc1Cl.[K+].[K+]>>Cn1nc(-c2c(F)cccc2Cl)nc1-c1ccc(COc2ccc(C(F)(F)F)cc2Cl)c(Cl)c1",
        "output": "127"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)CS(=O)(=O)c1cccc(-c2cnc(Nc3ccc(F)c(Cl)c3)nc2-n2ccc(C(F)(F)F)n2)c1.O=C(O)C(F)(F)F>>O=C(O)CS(=O)(=O)c1cccc(-c2cnc(Nc3ccc(F)c(Cl)c3)nc2-n2ccc(C(F)(F)F)n2)c1",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CSc1ncc(CNc2c(Cl)cccc2Cl)c(=O)[nH]1.O=P(Cl)(Cl)Cl>>CSc1ncc(CNc2c(Cl)cccc2Cl)c(Cl)n1",
        "output": "14"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.C[C@@H]1CNCCN1.Fc1ccc(CCl)cc1.O=C([O-])O.[Na+]>>C[C@@H]1CN(Cc2ccc(F)cc2)CCN1",
        "output": "156"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)NCCN.CCc1ccc(Oc2ccc(S(=O)(=O)Cl)cc2F)c(OC)c1>>CCc1ccc(Oc2ccc(S(=O)(=O)NCCNC(C)=O)cc2F)c(OC)c1",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cc(-c2ncc(C(F)(F)F)cc2Cl)ccc1C#N.Cl.O.c1ccncc1>>N#Cc1ccc(-c2ncc(C(F)(F)F)cc2Cl)cc1O",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cc2cc(OCCOC)ncc2n1Cc1cc(-c2ccc(Cl)s2)on1.CO>>COCCOc1cc2cc(C(=O)O)n(Cc3cc(-c4ccc(Cl)s4)on3)c2cn1",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.Nc1ccc2ccc(Cl)nc2n1.O.O=C(O)c1cccc(F)c1>>O=C(Nc1ccc2ccc(Cl)nc2n1)c1cccc(F)c1",
        "output": "744"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C[C@H](NC(=O)OC(C)(C)C)c1ccc([C@H](O)CO)cc1.Cc1ccc(S(=O)(=O)Cl)cc1.O.c1ccncc1>>Cc1ccc(S(=O)(=O)OC[C@@H](O)c2ccc([C@H](C)NC(=O)OC(C)(C)C)cc2)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c5cc(F)ccc5nn4cc3-c3ccccc3)cc2)CCC1.Cl>>NC1(c2ccc(-c3nc4c5cc(F)ccc5nn4cc3-c3ccccc3)cc2)CCC1",
        "output": "793"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#CCCO.CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O=C([O-])O.[Na+].c1c[nH]cn1>>C#CCCO[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1ccc(S(=O)(=O)Cl)cc1.CN(C)C=O.CN1CCOCC1.Cl.NCCC(F)(F)F>>CC(=O)c1ccc(S(=O)(=O)NCCC(F)(F)F)cc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrBr.CC(=O)C1CCCCCC1.CO>>O=C(CBr)C1CCCCCC1",
        "output": "173"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC[SiH](CC)CC.COc1ccc(C(O)C(C)C)cc1.O.O=C(O)C(F)(F)F>>COc1ccc(CC(C)C)cc1",
        "output": "447"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#Cc1ccc(N)nc1N.C1CCOC1.CCN(CC)CC.ON=C(Cl)Cc1ccc(Cc2ccc(F)cc2)o1>>Nc1ccc(-c2cc(Cc3ccc(Cc4ccc(F)cc4)o3)no2)c(N)n1",
        "output": "976"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CO.COC(=O)c1ccc(OC(F)F)cn1.Cl.[Cl-].[Na+].[Na+].[OH-]>>O=C(O)c1ccc(OC(F)F)cn1",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.Cc1ccc(Oc2ccc([N+](=O)[O-])cn2)cc1OC(F)(F)F.[Pd]>>Cc1ccc(Oc2ccc(N)cn2)cc1OC(F)(F)F",
        "output": "269"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)C1(c2ccc(Nc3cc(-c4ccccc4)nc(-c4ccc(C(C)=O)cc4)n3)cc2)CCC1.Cl.O.OCCO.[Na+].[OH-]>>CC(=O)c1ccc(-c2nc(Nc3ccc(C4(C(=O)O)CCC4)cc3)cc(-c3ccccc3)n2)cc1",
        "output": "203"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.ClCCl.O=C(NN1CCNCC1)c1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1.O=C(O)C(F)(F)F>>CS(=O)(=O)N1CCN(NC(=O)c2cnc(OCC(F)(F)F)c(-c3ccc(Cl)cc3)c2)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN[C@@H](CCc2ccc(Cl)cc2)C1.ClCCCl.[Na+]>>Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)[C@@H](CCc2ccc(Cl)cc2)C1",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1ccc2nc(COc3ccc(C45CC6CC(CC(C6)C4)C5)cc3)oc2c1.CSC.Cl.ClCCl.O.[Al+3].[Br-].[Br-].[Br-]>>O=C(O)c1ccc2nc(COc3ccc(C45CC6CC(CC(C6)C4)C5)cc3)oc2c1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)C[AlH]CC(C)C.CCOC(=O)c1ccc(N2CCC(NC(=O)c3ccccc3)CC2)cc1>>O=C(NC1CCN(c2ccc(CO)cc2)CC1)c1ccccc1",
        "output": "311"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(F)c([N+](=O)[O-])c1>>CNC(=O)c1ccc(F)c([N+](=O)[O-])c1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN=C=O.ClCCl.Cl[Cu].Cn1c2c(c3cc(O)ccc31)CCC21CCN(Cc2ccccc2)CC1>>CNC(=O)Oc1ccc2c(c1)c1c(n2C)C2(CC1)CCN(Cc1ccccc1)CC2",
        "output": "104"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)CCN.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)c1ccncc1.COc1ccc2cc(-c3cc(-c4cc(Cl)cc(Cl)c4)nn3[C@@H](C)c3ccc(C(=O)O)cc3)ccc2c1.Cl.Cl.ClCCl>>COc1ccc2cc(-c3cc(-c4cc(Cl)cc(Cl)c4)nn3[C@@H](C)c3ccc(C(=O)NCCC(=O)OC(C)(C)C)cc3)ccc2c1",
        "output": "821"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.ClCCCBr.O=C([O-])[O-].O=c1cc2c(n[nH]1)CCc1cc(O)ccc1-2.[K+].[K+]>>O=c1cc2c(n[nH]1)CCc1cc(OCCCCl)ccc1-2",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.Cl[Pd]Cl.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.Oc1cccc2cc(Br)c(F)cc12.[C-]#N.[C-]#N.[Fe+2].[Pd].[Pd].[Zn+2].[Zn].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>N#Cc1cc2cccc(O)c2cc1F",
        "output": "65"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(O)c1cc2ncc(Br)cn2n1.c1ncc(-c2nnc3n2CCNC3)cn1>>O=C(c1cc2ncc(Br)cn2n1)N1CCn2c(nnc2-c2cncnc2)C1",
        "output": "663"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCC(=O)O.CC(C)COC(=O)Cl.CCOC(C)=O.CN1CCOCC1.NCCc1cccc(Br)c1.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)NCC(=O)NCCc1cccc(Br)c1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)CCc1c(C)nn(C)c1-n1ccc2cc(Cl)ccc21.CO.O.[H-]>>Cc1nn(C)c(-n2ccc3cc(Cl)ccc32)c1CCCO",
        "output": "225"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.COc1ccccc1F.O.S=C=S>>COc1ccc(Br)cc1F",
        "output": "98"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1.O=c1c2ccncc2sn1CCCCO>>O=c1c2ccncc2sn1CCCCOS(=O)(=O)c1ccc([N+](=O)[O-])cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cc1cc(NC(=O)OC(C)(C)C)nc(C)c1C#N.N.[Ni]>>Cc1cc(NC(=O)OC(C)(C)C)nc(C)c1CN",
        "output": "560"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)(C)OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1.CCCCCCCOc1ccc(C(=O)Cl)cc1.ClCCl>>CCCCCCCOc1ccc(C(=O)Oc2ccc(C[C@H](NC(=O)OCc3ccccc3)C(=O)OC(C)(C)C)cc2)cc1",
        "output": "482"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)(c2ccc(Cl)cc2)C1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.C[C@@H]1CCc2ncnc(N3CCNCC3)c21.Cl.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>C[C@@H]1CCc2ncnc(N3CCN(C(=O)C4(c5ccc(Cl)cc5)CCN(C(=O)OC(C)(C)C)C4)CC3)c21",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.COc1cccc(-c2nc3ccc(OC)cc3s2)c1>>Oc1cccc(-c2nc3ccc(O)cc3s2)c1",
        "output": "20"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCCCCBr.COc1cccc(C)c1O>>COc1cccc(C)c1OCCCCBr",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CN2CCN1CC2.C1COCCO1.CN=C=O.CNC(=O)Cc1cccc(N)c1>>CNC(=O)Cc1cccc(NC(=O)NC)c1",
        "output": "176"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1c(C=O)cc(C(=O)O)cc1C(F)(F)F.Cl.NO.O=CO>>COc1c(C#N)cc(C(=O)O)cc1C(F)(F)F",
        "output": "453"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CCOCC.ClCCl.O=C(OO)c1cccc(Cl)c1.O=S(=O)(c1ccc(Cl)cc1)C(c1cccnc1)c1cc(F)ccc1F>>O=S(=O)(c1ccc(Cl)cc1)C(c1ccc[n+]([O-])c1)c1cc(F)ccc1F",
        "output": "262"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.COc1cc2ncnc(Sc3cccc(N)c3)c2cc1OC.O=C(Nc1cc(C(F)(F)F)n(-c2ccccc2)n1)Oc1ccccc1>>COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(C(F)(F)F)n(-c5ccccc5)n4)c3)c2cc1OC",
        "output": "948"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCc2cn(-c3ccc(C(N)=O)cc3)nc2CC1.CO.ClCCl.O=C(O)C(F)(F)F>>NC(=O)c1ccc(-n2cc3c(n2)CCNCC3)cc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCc1nc2ccccc2n1-c1ccc(CCN=[N+]=[N-])cc1.CO.[Pd]>>CCc1nc2ccccc2n1-c1ccc(CCN)cc1",
        "output": "89"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCn1cc(-c2ccnc3[nH]ccc23)c(-c2ccc(N)cc2)n1.O=C(Cl)c1ccccc1>>CCn1cc(-c2ccnc3[nH]ccc23)c(-c2ccc(NC(=O)c3ccccc3)cc2)n1",
        "output": "11"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CCCNC(=O)c1c(C)[nH]c(C=O)c1C.O=C1Cc2cc(Br)ccc2N1>>CCN(CC)CCCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(Br)cc32)c1C",
        "output": "440"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Cc1cc(F)ccc1[N+](=O)[O-].[C].[Pd]>>Cc1cc(F)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)C12CC3CC(C1)CC(c1ncc(-c4ccc(N)cc4)s1)(C3)C2.COC(=O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1.O=C=Nc1ccccc1F>>COC(=O)C12CC3CC(C1)CC(c1ncc(-c4ccc(NC(=O)Nc5ccccc5F)cc4)s1)(C3)C2",
        "output": "473"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=Cc1ccncc1.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.CN(C)C=O.COC(=O)CCc1cc(Br)c(Oc2cc(I)c(O)c(C(C)C)c2)c(Br)c1.[Pd+2]>>COC(=O)CCc1cc(Br)c(Oc2cc(/C=C/c3ccncc3)c(O)c(C(C)C)c2)c(Br)c1",
        "output": "725"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC[C@H](NC(=O)C1Cc2ccccc2C1)C(=O)N[C@@H](Cc1ccc(OC)cc1)C(=O)OCc1ccccc1.[OH-].[OH-].[Pd+2]>>COC[C@H](NC(=O)C1Cc2ccccc2C1)C(=O)N[C@@H](Cc1ccc(OC)cc1)C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCn1c(C)c(-c2ccccc2C)c2cc(O)ccc21.CCOC(=O)C(C)(C)Br>>CCCn1c(C)c(-c2ccccc2C)c2cc(OC(C)(C)C(=O)OCC)ccc21",
        "output": "305"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOc1c(C(C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(C)c1C1CN(C(=O)OCc2ccccc2)C1.CO.Cl.O.[Pd]>>CCOc1c(C(C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(C)c1C1CNC1",
        "output": "428"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.N#Cc1ccc(CBr)cc1.O=C([O-])[O-].Oc1cccc(F)c1.[K+].[K+]>>N#Cc1ccc(COc2cccc(F)c2)cc1",
        "output": "127"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C(N)=NO.O=C(O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)N2CCC(O)CC2)C1>>CC(C)c1noc(C2CC(c3ccc(OC(F)(F)F)cc3)CN(C(=O)N3CCC(O)CC3)C2)n1",
        "output": "728"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.ClCc1ccccn1.O=C([O-])[O-].O=[N+]([O-])c1ccc(O)cc1F.[K+].[K+]>>O=[N+]([O-])c1ccc(OCc2ccccn2)cc1F",
        "output": "616"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COC(=O)CBr.O.O=C([O-])[O-].Oc1c(Br)cc(-c2c3ccccc3c(Br)c3oc4ccccc4c23)cc1Br.[K+].[K+]>>COC(=O)COc1c(Br)cc(-c2c3ccccc3c(Br)c3oc4ccccc4c23)cc1Br",
        "output": "557"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCc1cc(CC(C)(Oc2ccccc2)C(=O)OCC)ccc1O.CCO.[Pd]>>CCCc1cc(CC(C)(Oc2ccccc2)C(=O)OCC)ccc1O",
        "output": "116"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1ccc(S(=O)(=O)n2cc(-c3nc(N[C@H](CO)C(C)(C)C)c(F)cc3C#N)c3cc(F)cnc32)cc1.ClCCl.N#Cc1cccnc1>>Cc1ccc(S(=O)(=O)n2cc(-c3nc(N[C@H](COS(C)(=O)=O)C(C)(C)C)c(F)cc3C#N)c3cc(F)cnc32)cc1",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#Cc1cc(OCc2ccccc2)c(OCc2ccccc2)nn1.C1CCOC1.CCN(CC)CC.CCOC(C)=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.FC(F)(F)c1ccc(Br)nc1.[Cu]I>>FC(F)(F)c1ccc(C#Cc2cc(OCc3ccccc3)c(OCc3ccccc3)nn2)nc1",
        "output": "777"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CNCCCCCCCCCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1.Cl.Cl.Nc1c(F)c(N)c(F)c(F)c1F.O=C(O)c1cc(F)ccc1O>>CN(CCCCCCCCCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)c1cc(F)ccc1O",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=[N+]=[N-].CC(C)(C)OC(=O)NCC#CC[C@H](N)C(=O)O.CCO.CCOCC>>COC(=O)[C@@H](N)CC#CCNC(=O)OC(C)(C)C",
        "output": "60"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCOC(=O)CC(C)c1ccc(-c2ccc(F)cc2F)cc1.Cl>>CC(CC(=O)O)c1ccc(-c2ccc(F)cc2F)cc1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccc(Cl)c(C(=O)N2C[C@@H]3C[C@@H]3C[C@H]2CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)n1.[F-]>>Cc1ccc(Cl)c(C(=O)N2C[C@@H]3C[C@@H]3C[C@H]2CO)n1",
        "output": "781"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(CCCl)S(=O)(=O)c1cc(Br)ccc1Br.Fc1ccc2[nH]c(C3CCNCC3)nc2c1>>CN(CCN1CCC(c2nc3cc(F)ccc3[nH]2)CC1)S(=O)(=O)c1cc(Br)ccc1Br",
        "output": "138"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.COC(=O)C1(CN(C(=O)C(F)(F)F)[C@@H]2C[C@H]2c2ccccc2)CCNCC1.ClCCCl.O=Cc1ccccc1.[Na+]>>COC(=O)C1(CN(C(=O)C(F)(F)F)[C@@H]2C[C@H]2c2ccccc2)CCN(Cc2ccccc2)CC1",
        "output": "567"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CO.Nc1cc(Oc2ccc(NC(=O)NC(=O)Cc3cccc(OCc4ccccc4)c3)cc2F)ccn1.[Pd]>>Nc1cc(Oc2ccc(NC(=O)NC(=O)Cc3cccc(O)c3)cc2F)ccn1",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cc(C)c(C#N)c(OC)n1.CO.[Na+].[OH-]>>COc1nc(C(=O)O)cc(C)c1C#N",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC[C@H]1CN(C(=O)C2CCOCC2)Cc2ccc(C(=O)OC)cc2O1.NO.[Na+].[OH-]>>COC[C@H]1CN(C(=O)C2CCOCC2)Cc2ccc(C(=O)NO)cc2O1",
        "output": "988"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCC(CCO)c1ccc(Cl)c2nc(Oc3c(C)cc(Cl)cc3Cl)n(C)c12.ClCCl.O=C([O-])O.[Na+]>>CCC(CC=O)c1ccc(Cl)c2nc(Oc3c(C)cc(Cl)cc3Cl)n(C)c12",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.ClCCCl.O.O=C(O)c1ccc2[nH]c(-c3n[nH]cc3NC(=O)c3c(F)cccc3F)nc2c1.On1nnc2ccccc21.[Cl-].[NH4+]>>NC(=O)c1ccc2[nH]c(-c3n[nH]cc3NC(=O)c3c(F)cccc3F)nc2c1",
        "output": "358"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.NCCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2.O=C(O)c1c[nH]c2ccccc12.O=C(n1ccnc1)n1ccnc1>>O=C(NCCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2)c1c[nH]c2ccccc12",
        "output": "674"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)C[C@@H]1CCc2cc(OCCO)ccc21.Cc1ccc(O)c(C)n1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)C[C@@H]1CCc2cc(OCCOc3ccc(C)nc3C)ccc21",
        "output": "547"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)[C@@H](Nc1ccc(CNC(=O)[C@@H]2SCCN2C(=O)C[C@@H](Cc2cc(F)c(F)cc2F)NC(=O)OC(C)(C)C)cc1)C(C)C.CO.O.O.[Li]O>>CC(C)[C@H](Nc1ccc(CNC(=O)[C@@H]2SCCN2C(=O)C[C@@H](Cc2cc(F)c(F)cc2F)NC(=O)OC(C)(C)C)cc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCCCCCOC(C)c1ccc(-c2ccc(C(=O)OCc3ccccc3)cc2)cc1.CO.[Pd]>>CCCCCCCCOC(C)c1ccc(-c2ccc(C(=O)O)cc2)cc1",
        "output": "290"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=C(NC[C@@H]1CN(CCn2c(=O)ccc3ccc(F)cc32)CC[C@@H]1O)OCc1ccccc1.[OH-].[OH-].[Pd+2]>>NC[C@@H]1CN(CCn2c(=O)ccc3ccc(F)cc32)CC[C@@H]1O",
        "output": "574"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)CNC(=O)C1=C(O)c2cc(Br)ccc2C(C)(C)C1=O.O=C(O)C(F)(F)F>>CC1(C)C(=O)C(C(=O)NCC(=O)O)=C(O)c2cc(Br)ccc21",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)Oc2cc3nonc3cc2C(N)C1O.CCN(CC)CC.ClCCl.O=C(Cl)CCl>>CC1(C)Oc2cc3nonc3cc2C(NC(=O)CCl)C1O",
        "output": "206"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCCCCC=C[C@@H]2C[C@@]2(C(=O)NS(=O)(=O)C2CC2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O.CC(C)(C)[O-].COc1ccc2c(Cl)cc(-c3nc(C4CC4)cs3)nc2c1Cl.CS(C)=O.ClCCl.[K+]>>COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6CC6)C[C@H]5C=CCCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N4C3)cc(-c3nc(C4CC4)cs3)nc2c1Cl",
        "output": "651"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=CBr)c1ccncc1.CC1Cc2[nH]c3ccc(Cl)cc3c2CN1C.CN(C)C=O.O.O=C(O)[C@@H]1CCCN1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>C/C(=C\\n1c2c(c3cc(Cl)ccc31)CN(C)C(C)C2)c1ccncc1",
        "output": "987"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1nc(N2CCN(Cc3ccc(F)cc3)C2=O)sc1C(=O)O.Cc1nc(N2CCN(Cc3csc4ccc(Cl)cc34)C2=O)sc1C(=O)O.Cn1cc(CN)cn1>>Cc1nc(N2CCN(Cc3ccc(F)cc3)C2=O)sc1C(=O)NCc1cnn(C)c1",
        "output": "534"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(C)C(=O)Cl.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.Nc1ccc(-n2nc3c4cccc(F)c4[nH]cc-3c2=O)cc1>>CCC(C)C(=O)Nc1ccc(-n2nc3c4cccc(F)c4[nH]cc-3c2=O)cc1",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(=O)N1CCc2nc(-c3ccc(OCCCCl)cc3)sc2C1.CC1CCCCN1>>CC(=O)N1CCc2nc(-c3ccc(OCCCN4CCCCC4C)cc3)sc2C1",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)Sc1ccc2nccc(Cl)c2c1.CO.O.O=S([O-])OO.[K+]>>CC(C)(C)S(=O)(=O)c1ccc2nccc(Cl)c2c1",
        "output": "730"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.Cc1cccc(CBr)c1F.Nc1nc(N)c2c(N3CCNCC3)cccc2n1>>Cc1cccc(CN2CCN(c3cccc4nc(N)nc(N)c34)CC2)c1F",
        "output": "248"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOP(=O)(OCC)c1ccc2cccc(-c3cccc4ccccc34)c2n1.C[Si](C)(C)Br.ClCCl>>O=P(O)(O)c1ccc2cccc(-c3cccc4ccccc34)c2n1",
        "output": "535"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1cc(C(=O)Nc2cc(C(F)(F)F)ccc2F)ccc1C.O.[Li+].[OH-]>>Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccc2F)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.COC(=O)CSCC(=O)Nc1ccc(CO)cc1.ClCCl>>COC(=O)CSCC(=O)Nc1ccc(C=O)cc1",
        "output": "179"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCN(Cc1ccccc1)c1ccc(Br)cc1.CN(C)C=O.ClCCl.[K+]>>CCN(Cc1ccccc1)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1",
        "output": "942"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=O.ClCCl.OCCc1ccc(Br)cc1>>CCNC(=O)OCCc1ccc(Br)cc1",
        "output": "235"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1ccnc(F)c1.O=C(O)C(F)(F)F>>NC(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1ccnc(F)c1",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.ClCCl.NCc1ccnc2ccccc12.O.O=S(=O)(Cl)c1ccc(C#Cc2ccccn2)cc1>>O=S(=O)(NCc1ccnc2ccccc12)c1ccc(C#Cc2ccccn2)cc1",
        "output": "43"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)c1csc(N)n1.Cc1c(Cl)cccc1S(=O)(=O)Cl>>Cc1c(Cl)cccc1S(=O)(=O)Nc1nc(C(C)(C)C)cs1",
        "output": "637"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCc1cc(-c2ccc(CN)o2)c(C)[nH]c1=O.O=C(Cl)c1ccccc1>>CCc1cc(-c2ccc(CNC(=O)c3ccccc3)o2)c(C)[nH]c1=O",
        "output": "271"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cl.Cl.NCCCCCCCCCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1.O=C(O)c1cc(F)ccc1O>>O=C(Nc1ccccc1-c1ccccc1)OC1CCN(CCCCCCCCCNC(=O)c2cc(F)ccc2O)CC1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.Cc1[nH]nc2c1c(=O)[nH]c1c(OCCCNC(=O)OC(C)(C)C)cccc12.Cl>>Cc1[nH]nc2c1c(=O)[nH]c1c(OCCCN)cccc12",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)CCCCCCN1CC(N2CCCCC2)Cc2nc(-c3ccc(C)cc3)c(-c3ccc(C)cc3)nc21.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>Cc1ccc(-c2nc3c(nc2-c2ccc(C)cc2)N(CCCCCCC(=O)O)CC(N2CCCCC2)C3)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCN(CC)CC.CN(C)C=O.CNOC.Cl.O=C(O)CCc1ccncc1.On1nnc2ccccc21>>CON(C)C(=O)CCc1ccncc1",
        "output": "54"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1ccc(C2COCCO2)c2sc(NC(=O)c3ccnc(Br)c3)nc12.CS(C)=O.O=C([O-])[O-].OC1CCNCC1.[Cs+].[Cs+]>>COc1ccc(C2COCCO2)c2sc(NC(=O)c3ccnc(N4CCC(O)CC4)c3)nc12",
        "output": "647"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.O=C([O-])O.OCc1cccc2c1OCCN2.[Na+]>>CC(C)(C)OC(=O)N1CCOc2c(CO)cccc21",
        "output": "827"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=C(O)c1cn(-c2ccc(F)cc2)c2ccc(O)cc2c1=O.O=C([O-])O.O=S(=O)(O)O.[Na+]>>COC(=O)c1cn(-c2ccc(F)cc2)c2ccc(O)cc2c1=O",
        "output": "521"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#Cc1c(N)ccc(C(=O)OC)c1Cl.COC(=O)c1cc(CC(C)C)c(N)c(C#C[Si](C)(C)C)c1Cl>>C#Cc1c(N)c(CC(C)C)cc(C(=O)OC)c1Cl",
        "output": "337"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(-c3cc(NS(C)(=O)=O)ccc3O)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12.N.O=C(O)C(F)(F)F>>Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cc(NS(C)(=O)=O)ccc5O)c34)n(-c3ccccc3)c(=O)c12",
        "output": "897"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.Nc1cc(Cl)nc(Cl)c1[N+](=O)[O-].O=C([O-])[O-].[Na+].[Na+]>>CC(=O)Nc1cc(Cl)nc(Cl)c1[N+](=O)[O-]",
        "output": "6"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1=COCCC1.CCOC(C)=O.Cc1c(O)c(C(F)(F)F)nn1CCO.Cc1ccc(S(=O)(=O)O)cc1.ClCCl>>Cc1c(O)c(C(F)(F)F)nn1CCOC1CCCCO1",
        "output": "306"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CSc1nc(C)cc(Cl)n1.Cl.NCC(F)(F)F.O>>CSc1nc(C)cc(NCC(F)(F)F)n1",
        "output": "166"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1ccc(Cn2nc(-c3cc(Cl)cc(Cl)c3)cc2C2CCNCC2)cc1.ClCCl.O=S(=O)(Cl)c1ccccc1.c1ccncc1>>COC(=O)c1ccc(Cn2nc(-c3cc(Cl)cc(Cl)c3)cc2C2CCN(S(=O)(=O)c3ccccc3)CC2)cc1",
        "output": "99"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOCC.Cl.N#Cc1ccc(F)c(F)c1.[Br-].[Ce+3].[Cl-].[Cl-].[Cl-].[Li+].[Li]C.[NH4+].[OH-]>>NCc1ccc(F)c(F)c1",
        "output": "175"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COCCOc1cnc(-c2cccc(C(CCO[Si](C)(C)C(C)(C)C)c3nn(-c4cnn(C)c4)ccc3=O)c2)nc1.Cl>>COCCOc1cnc(-c2cccc(C(CCO)c3nn(-c4cnn(C)c4)ccc3=O)c2)nc1",
        "output": "708"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)N(CCOc1ccccc1)C1CCCCC1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CCN(CCOc1ccccc1)C1CCCCC1",
        "output": "112"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.NC1(CO)CCN(Cc2ccccc2)C1>>CC(C)(C)OC(=O)NC1(CO)CCN(Cc2ccccc2)C1",
        "output": "631"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1CCC(N)c2ccccc21.COc1ccc(CC2NCCc3cc(OC)c(OC(C)C)cc32)cc1OC.O=C(Br)CBr>>COc1ccc(CC2c3cc(OC(C)C)c(OC)cc3CCN2CC(=O)NC2CCC(C)c3ccccc32)cc1OC",
        "output": "946"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)N1CCn2c(CC3(n4ccc5cccnc54)CCCC3)nc(=O)c(OCc3ccccc3)c2C1=O.CN1CCn2c(CC3(n4ccc5cccnc54)CCCC3)nc(=O)c(O)c2C1=O>>CC(C)N1CCn2c(CC3(n4ccc5cccnc54)CCCC3)nc(=O)c(O)c2C1=O",
        "output": "492"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CO.Nc1ccccc1N.O=CC1CC1.[BH3-]C#N.[Na+]>>Nc1ccccc1NCC1CC1",
        "output": "336"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)Cl.COc1cc([N+](=O)[O-])ccc1OCCO.O.c1ccncc1>>COc1cc([N+](=O)[O-])ccc1OCCOC(C)=O",
        "output": "126"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Clc1cc(Cl)nc(Cl)n1.OB(O)c1ccccc1>>Clc1cc(-c2ccccc2)nc(Cl)n1",
        "output": "884"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)CCCCOc1ccc2[nH]c(=O)c(C)nc2c1.CO.Cl.O.[Na+].[OH-]>>Cc1nc2cc(OCCCCC(=O)O)ccc2[nH]c1=O",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.CS(N)(=O)=O.Cl.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)C1(c2ccc(Br)cc2)CC1.[H-].[Na+]>>CS(=O)(=O)NC(=O)C1(c2ccc(Br)cc2)CC1",
        "output": "644"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C(=O)OC(C)(C)C)C1CN(c2nc3ncc(Cl)c(Cl)c3n3cnnc23)C1.ClCCl.O=C(O)C(F)(F)F>>CNC1CN(c2nc3ncc(Cl)c(Cl)c3n3cnnc23)C1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1cc(O)cc2c1CC(c1ccc(O)cc1)C1CCCC21.[Br-].[Li]CCCC>>C=Cc1cc(O)cc2c1CC(c1ccc(O)cc1)C1CCCC21",
        "output": "649"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC1(O)CNC1.ClCCCl.Cn1c(CC=O)nc2c(N3CCOCC3)nc(Cl)nc21.[Na+]>>Cn1c(CCN2CC(C)(O)C2)nc2c(N3CCOCC3)nc(Cl)nc21",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COC(=O)CCc1cc(O[Si](C)(C)C(C)(C)C)ccc1C1CC1.[F-]>>COC(=O)CCc1cc(O)ccc1C1CC1",
        "output": "754"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCN(C(C)C)C(C)C.O=C=NCc1ccc(F)cc1.c1nc(N2CCNCC2)c2sc(-c3cnn(CCN4CCOCC4)c3)cc2n1>>O=C(NCc1ccc(F)cc1)N1CCN(c2ncnc3cc(-c4cnn(CCN5CCOCC5)c4)sc23)CC1",
        "output": "583"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN1CCOCC1.CCN=C=NCCCN(C)C.COc1ccnc(N2CC(C(=O)O)N(C)C2=O)n1.Cl.ClCCl.NCc1ccc(Cl)cc1Cl.O.O=C([O-])O.On1nnc2ccccc21.[Na+]>>COc1ccnc(N2CC(C(=O)NCc3ccc(Cl)cc3Cl)N(C)C2=O)n1",
        "output": "797"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(CCc2nc3c(N4CCNCC4)nc(N)nc3s2)cc1OC.O=C(O)COc1ccc(Br)cc1>>COc1ccc(CCc2nc3c(N4CCN(C(=O)COc5ccc(Br)cc5)CC4)nc(N)nc3s2)cc1OC",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCI.Nc1nc(-c2ccco2)c(-c2ccc(=O)[nH]c2)c(-c2ccco2)n1>>CCCn1cc(-c2c(-c3ccco3)nc(N)nc2-c2ccco2)ccc1=O",
        "output": "302"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCOC(=O)CC(C)O.CN(C)c1ccncc1.ClCCl.N#CCC(=O)O>>CCOC(=O)CC(C)OC(=O)CC#N",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COc1cc(C)c([N+](=O)[O-])cc1C(F)(F)F.[C].[Pd]>>COc1cc(C)c(N)cc1C(F)(F)F",
        "output": "202"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C[C@H]1CN(c2ccc3ccccc3n2)CCN1.O=C(NCC(F)(F)F)C1(CCCCBr)c2ccccc2Oc2ccccc21>>C[C@H]1CN(c2ccc3ccccc3n2)CCN1CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2Oc2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.C[C@@H](OCc1cc(Cl)cc(-c2cc(N)nn2-c2ccc(F)cc2)c1)C(F)(F)F.Cl.ClC(Cl)Cl.O=C1C[C@H](C(=O)O)CN1>>C[C@@H](OCc1cc(Cl)cc(-c2cc(NC(=O)[C@@H]3CNC(=O)C3)nn2-c2ccc(F)cc2)c1)C(F)(F)F",
        "output": "795"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COC(=O)[C@H](O)CNC(=O)c1ccc(CN(C(=O)Nc2cccc(C(C)(C)C)c2)c2ccc(C3CCCCC3)cc2)cc1.[Na+].[OH-]>>CC(C)(C)c1cccc(NC(=O)N(Cc2ccc(C(=O)NC[C@@H](O)C(=O)O)cc2)c2ccc(C3CCCCC3)cc2)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)OCc3ccccc3)n(-c3ccccc3)n2)CC1.CCOC(C)=O>>CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)O)n(-c3ccccc3)n2)CC1",
        "output": "186"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1cc(NCc2c(C)cccc2C)c2nc(C)c(C)n2c1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>Cc1cccc(C)c1CNc1cc(CO)cn2c(C)c(C)nc12",
        "output": "383"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[Si](C)(C)[N-][Si](C)(C)C.Nc1cc(Br)ccn1.[Na+]>>CC(C)(C)OC(=O)Nc1cc(Br)ccn1",
        "output": "849"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(N)CO.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1ncnc2ccc(-c3cc(F)cc(C(=O)O)c3)nc12>>CC(CO)NC(=O)c1cc(F)cc(-c2ccc3ncnc(N)c3n2)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2ccc(Cl)s2)CN1.O=C(O)Cn1ccnn1>>O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2ccc(Cl)s2)CN1C(=O)Cn1ccnn1",
        "output": "297"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)CBr.CCOC(C)=O.CN(C)C=O.O.O=[N+]([O-])c1cc(-c2ccccc2)c2[nH]ccc2c1.[H-].[Na+]>>CC(C)Cn1ccc2cc([N+](=O)[O-])cc(-c3ccccc3)c21",
        "output": "470"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.Cl.N#Cc1ccc(-c2ccc(Cl)cc2Cl)nc1Cl.N#Cc1ccc(NC2CCCNC2)nc1>>N#Cc1ccc(NC2CCCN(c3nc(-c4ccc(Cl)cc4Cl)ccc3C#N)C2)nc1",
        "output": "220"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCCCC2c2coc3cccc-3c2)CC1.O=C(O)c1ccc(Cl)cc1>>O=C(N[C@@H]1CC[C@@H](CCN2CCCCC2c2coc3cccc-3c2)CC1)c1ccc(Cl)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1noc(C#CC(C)(C)C)c1C.CO.Cl.O.[Na+].[OH-]>>Cc1c(C(=O)O)noc1C#CC(C)(C)C",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(CC)CC.CCOc1ccc(C(=O)Cl)cc1.CS(=O)(=O)c1ccc(-n2ncc3c(OC4CCNCC4)ncnc32)c(F)c1>>CCOc1ccc(C(=O)N2CCC(Oc3ncnc4c3cnn4-c3ccc(S(C)(=O)=O)cc3F)CC2)cc1",
        "output": "201"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(OCCCN4CCCC4CN4CCCC4)cccc32)CC1.O=C(O)C(F)(F)F>>Clc1ccc(OCc2nc3c(OCCCN4CCCC4CN4CCCC4)cccc3n2CCCC2CCNCC2)cc1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CCO.CCOC(=O)Cl.Cc1nc2cc(C(=O)O)ccc2s1.Cl.ClC(Cl)Cl.O=C([O-])O.[BH4-].[Na+].[Na+]>>Cc1nc2cc(CO)ccc2s1",
        "output": "72"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCC(F)COS(=O)(=O)c1ccc(C)cc1.CCCCCCCCc1cnc(-c2ccc(O)cc2)nc1.CCCCO.ClC(Cl)Cl.O.[Na+].[OH-]>>CCCCCCCCc1cnc(-c2ccc(OCC(F)CCCCC)cc2)nc1",
        "output": "438"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O.O=C(Nc1ccc(N2CCN(C(=O)[C@H]3CCC[C@@H]3C(=O)OCc3ccccc3)CC2)cc1F)c1nc(-c2ccccc2)oc1C(F)(F)F.[Li+].[OH-]>>O=C(Nc1ccc(N2CCN(C(=O)[C@H]3CCC[C@@H]3C(=O)O)CC2)cc1F)c1nc(-c2ccccc2)oc1C(F)(F)F",
        "output": "186"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCc1cnc(N2CCC(Oc3nc4ccc(C5=CCN(S(=O)(=O)CCN6C(=O)c7ccccc7C6=O)CC5)cc4s3)CC2)nc1.CO.ClCCl.NN>>CCCc1cnc(N2CCC(Oc3nc4ccc(C5=CCN(S(=O)(=O)CCN)CC5)cc4s3)CC2)nc1",
        "output": "242"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)N(C)C.CC(C)Oc1cccc(C(=O)O)c1.CN(C)C=O.Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1.O=C(Cl)C(=O)Cl>>CC(C)Oc1cccc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)c1",
        "output": "50"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)CN([C@H](CO)CCCNC(=O)[C@@H](N)Cc1cccc2ccccc12)S(=O)(=O)c1ccc(N)cc1.O=C(O)CC(F)(F)F>>CC(C)CN([C@H](CO)CCCNC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)CC(F)(F)F)S(=O)(=O)c1ccc(N)cc1",
        "output": "133"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CCN(C(C)C)C(C)C.COc1ccc(N(C)c2nc(NCCN)nc3ccccc23)cc1OC.ClCCl>>COc1ccc(N(C)c2nc(NCCNC(C)=O)nc3ccccc23)cc1OC",
        "output": "45"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC)C1CCNC1.C[C@@H]1CCC[C@](O)(CNC(=O)c2c(Cl)ccc3nc(Cl)ccc23)C1>>CCN(CC)C1CCN(c2ccc3c(C(=O)NC[C@@]4(O)CCC[C@@H](C)C4)c(Cl)ccc3n2)C1",
        "output": "220"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C(Nc1ccccc1Oc1ccc(Cl)cc1Cl)C1CCNCC1>>CS(=O)(=O)N1CCC(C(=O)Nc2ccccc2Oc2ccc(Cl)cc2Cl)CC1",
        "output": "584"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Fc1ccc(OCc2cn3cc(Br)cnc3n2)cc1.Nc1cc(Cl)ccc1B(O)O>>Nc1cc(Cl)ccc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1",
        "output": "871"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2ccc(C(F)(F)F)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>FC(F)(F)c1ccc(OC2CCNCC2)cc1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cc1cc(NCCN)c2ccccc2n1.ClCCl.c1ccc(OCC2CO2)cc1>>Cc1cc(NCCNCC(O)COc2ccccc2)c2ccccc2n1",
        "output": "16"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#C[Si](C)(C)C.COC(=O)Cc1ccccc1I.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>COC(=O)Cc1ccccc1C#C[Si](C)(C)C",
        "output": "826"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.Nc1cncc(Br)c1.O=C(Cl)c1ccccc1>>O=C(Nc1cncc(Br)c1)c1ccccc1",
        "output": "501"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COCCOC.COc1ccc(F)cc1B(O)O.Clc1cccc(Cl)c1Br.O=C([O-])[O-].[K+].[K+]>>COc1ccc(F)cc1-c1c(Cl)cccc1Cl",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Cl.Cc1ccc(F)cc1-c1ccc2cc(N)ncc2c1.O.c1ccncc1>>CC(=O)Nc1cc2ccc(-c3cc(F)ccc3C)cc2cn1",
        "output": "332"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CNOC.Cl.ClCCl.O=C(O)c1cc[nH]c(=O)c1.On1nnc2ccccc21>>CON(C)C(=O)c1cc[nH]c(=O)c1",
        "output": "828"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrP(Br)Br.O.OCCCCCCCCCC=CC(F)(F)Cl>>FC(F)(Cl)C=CCCCCCCCCCBr",
        "output": "301"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl.OC(CC1CC1)c1ccc(Cl)cc1>>O=C(CC1CC1)c1ccc(Cl)cc1",
        "output": "32"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc(-n2c(=S)[nH]c3cc(C(=O)O)cc(Cl)c3c2=O)nc1OC.F[P-](F)(F)(F)(F)F.NCc1ccc(Cl)cc1>>COc1ccc(-n2c(=S)[nH]c3cc(C(=O)NCc4ccc(Cl)cc4)cc(Cl)c3c2=O)nc1OC",
        "output": "753"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)Cc1ccc(Oc2ccc(C(=O)NCCc3c(Cl)cccc3Cl)cc2)c(C#N)c1.ClCCl.O=C(O)C(F)(F)F>>N#Cc1cc(CC(=O)O)ccc1Oc1ccc(C(=O)NCCc2c(Cl)cccc2Cl)cc1",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCCc1oc2ccccc2c1/C=N/OCCCOc1ccc(C(=O)OC)c(NC(=O)c2ccc(C(C)(C)C)cc2)c1.CCO.O.[Na+].[OH-]>>CCCCc1oc2ccccc2c1/C=N/OCCCOc1ccc(C(=O)O)c(NC(=O)c2ccc(C(C)(C)C)cc2)c1",
        "output": "222"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCC1CC1.CN(C)C=O.O=C([O-])[O-].Oc1ccnc(Br)c1.[Cs+].[Cs+]>>Brc1cc(OCC2CC2)ccn1",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)CCCBr.COc1ccc(OC)c(CCN)c1>>CCOC(=O)CCCNCCc1cc(OC)ccc1OC",
        "output": "147"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.C1COCCO1.CCOC(=O)CCc1ccc(N(Cc2ccc3c(c2C)N(CC(=O)OC(C)(C)C)CCC3)C(=O)C(F)(F)F)cc1F.Cl>>CCOC(=O)CCc1ccc(N(Cc2ccc3c(c2C)N(CC(=O)O)CCC3)C(=O)C(F)(F)F)cc1F",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccccc1-c1ccc2ccccc2c1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>BrCc1ccccc1-c1ccc2ccccc2c1",
        "output": "29"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(C=O)CC1.CN=C=O.CS(=O)(=O)c1ccc(N2CCNCC2)cc1.ClCCl.[Na+]>>CC(C)(C)OC(=O)N1CCC(CN2CCN(c3ccc(S(C)(=O)=O)cc3)CC2)CC1",
        "output": "484"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOc1cc(C(O)c2cccc(OC)c2)ccc1OC.ClCCl.O=[Mn]=O>>CCOc1cc(C(=O)c2cccc(OC)c2)ccc1OC",
        "output": "59"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)OB(c2cnccc2F)OC1(C)C.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(Br)c1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cnccc2F)c1",
        "output": "967"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1cc(-c2cc(C(F)(F)F)nn2-c2ccccc2Cl)ccc1-c1cccc(S(C)(=O)=O)c1.O.[Na+].[OH-]>>CS(=O)(=O)c1cccc(-c2ccc(-c3cc(C(F)(F)F)nn3-c3ccccc3Cl)cc2C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CI.CN(C)C=O.Cl.O=C(O)c1cc(OCc2ccccc2)nn1-c1ccccc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cc(OCc2ccccc2)nn1-c1ccccc1",
        "output": "415"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCc2ccc(C#Cc3cc(-c4nn(CC(O)CN5CCCCC5)c5c4CN(S(C)(=O)=O)CC5)ccc3Cl)cc2C1.CCN(CC)CC.[Cu]I>>CS(=O)(=O)N1CCc2c(c(-c3ccc(Cl)c(C#Cc4ccc5c(c4)CNCC5)c3)nn2CC(O)CN2CCCCC2)C1",
        "output": "887"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C)c1ccc(Br)cc1.Cc1noc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)c1NC(=O)OC(C)c1ccccc1F.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1>>CCOC(=O)C(C)c1ccc(-c2ccc(-c3onc(C)c3NC(=O)OC(C)c3ccccc3F)cc2)cc1",
        "output": "933"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OCc1nc(N2CCN(C(=O)OC(C)(C)C)CC2)no1.CO.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCN(c2noc(CO)n2)CC1",
        "output": "348"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)c1cn(-c2cccc(-c3cc(F)ccc3OC)c2)cn1.[K+].[OH-]>>COc1ccc(F)cc1-c1cccc(-n2cnc(C(=O)O)c2)c1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)C(=O)CCc1ccc[nH]1.CCOC(C)=O.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCN(CC)CCCc1ccc[nH]1",
        "output": "112"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1cc(O)cc(C(=O)OCC)n1.CI.CN(C)C=O.O.[H-].[Na+]>>CCOC(=O)c1cc(OC)cc(C(=O)OCC)n1",
        "output": "62"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.NCc1ccccn1.O=C(O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F>>O=C(NCc1ccccn1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C)(C)Oc1ccc(CCCC(=O)O)cc1.CCOC(=O)C(C)(C)Oc1ccc(CCCc2nn(Cc3ccc(C)cc3)c(=O)n2C)cc1.CCOC(C)=O.CN(C)C=O.O=C(Cl)C(=O)Cl>>CCOC(=O)C(C)(C)Oc1ccc(CCCC(=O)Cl)cc1",
        "output": "56"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(CO)cc2)CC1.ClC(Cl)Cl.O=[Mn]=O>>CC(C)(C)OC(=O)N1CCN(c2ccc(C=O)cc2)CC1",
        "output": "179"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCn1c([C@@H](C)NS(=O)(=O)c2ccc(C(=O)O)n2C)nc2ccc(C(F)(F)F)cc21.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.CO.CO.F[P-](F)(F)(F)(F)F.N.O>>CCn1c([C@@H](C)NS(=O)(=O)c2ccc(C(N)=O)n2C)nc2ccc(C(F)(F)F)cc21",
        "output": "136"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC[SiH](CC)CC.ClCCl.O=C(c1ccc2c(c1)CCCO2)c1cc(I)ccc1Br>>Brc1ccc(I)cc1Cc1ccc2c(c1)CCCO2",
        "output": "181"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN.Cl.O=C1Nc2cc(C(=O)O)ccc2/C1=C(/Nc1ccc(CN2CCCCC2)cc1)c1ccccc1>>CNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\\Nc1ccc(CN2CCCCC2)cc1)c1ccccc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCc1cc(CCC=O)nn1C(C)(C)C.CCN(C(C)C)C(C)C.[Na+].c1ccc(N2CCNCC2)cc1>>CCCc1cc(CCCN2CCN(c3ccccc3)CC2)nn1C(C)(C)C",
        "output": "484"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1nc(C(=O)N2[C@H]3C[C@H]3C[C@H]2CN)c(-c2cccc(F)c2)s1.O=C(O)c1nccc2ccccc12>>Cc1nc(C(=O)N2[C@H]3C[C@H]3C[C@H]2CNC(=O)c2nccc3ccccc23)c(-c2cccc(F)c2)s1",
        "output": "137"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(=O)(=O)Cl.Nc1ncnn2c(C3CCNCC3)cc(-c3ccc4sc(Cc5ccccc5)nc4c3)c12>>CS(=O)(=O)N1CCC(c2cc(-c3ccc4sc(Cc5ccccc5)nc4c3)c3c(N)ncnn23)CC1",
        "output": "584"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.Cl[Pd]Cl.Nc1ncc(Br)cc1-c1nc2cccnc2o1.O.O=C(O)c1ccc(B(O)O)cc1.[Cs+].[F-].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Nc1ncc(-c2ccc(C(=O)O)cc2)cc1-c1nc2cccnc2o1",
        "output": "833"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)COc1ccc(Cl)cc1C#Cc1ccc2c(c1)S(=O)(=O)CC2.CCCCC.ClCCl>>O=C(O)COc1ccc(Cl)cc1C#Cc1ccc2c(c1)S(=O)(=O)CC2",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1nc(Br)c(F)cc1N.ClCCl.Cl[Pd]Cl.OB(O)c1c(F)cccc1F.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COC(=O)c1nc(-c2c(F)cccc2F)c(F)cc1N",
        "output": "869"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(C)=CCCC(=CCBr)CC.Oc1ccc2c(c1)OCCC2>>CCC(C)=CCCC(=CCOc1ccc2c(c1)OCCC2)CC",
        "output": "77"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.ClCCl.N[C@@H](CO)Cc1c[nH]c2ccccc12.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OC[C@H](N)Cc1c[nH]c2ccccc12",
        "output": "193"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc([N+](=O)[O-])c(C=O)cc1OCc1ccccc1.O=C(O)C(F)(F)F>>COc1cc([N+](=O)[O-])c(C=O)cc1O",
        "output": "698"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1ccc2c(c1)c(-c1cc3ccccc3o1)nn2C1CCCCO1.CO.Cl.O.[Na+].[OH-]>>O=C(O)c1ccc2c(c1)c(-c1cc3ccccc3o1)nn2C1CCCCO1",
        "output": "5"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCn1c2ccccc2c2cc(NC(=O)CC(C)CC(=O)O)ccc21.O>>CCn1c2ccccc2c2cc(NC(=O)CC(C)CCO)ccc21",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1cncc(Br)c1.CCO.O.[BH4-].[Na+].[Na+].[OH-]>>CC(O)c1cncc(Br)c1",
        "output": "449"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCBr.O.OCc1ccccc1Br.[H-].[Na+]>>CCCOCc1ccccc1Br",
        "output": "95"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.CN(C)CCCCl.Cl.O.[H-].[H][H].[Na+].c1ccc2c(c1)[nH]c1ccccc12>>CN(C)CCCn1c2ccccc2c2ccccc21",
        "output": "42"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "I.Nc1nc2c(s1)Cc1ccccc1-2.O=C(Cl)c1ccccc1.c1ccncc1>>O=C(Nc1nc2c(s1)Cc1ccccc1-2)c1ccccc1",
        "output": "673"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCCCCCCCCCCCCCCCCNCCCCCCCCCCCCCCCCCC.CCN(C(C)C)C(C)C.O=C(Cl)c1cccc(S(=O)(=O)Cl)c1>>CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)C(=O)c1cccc(S(=O)(=O)Cl)c1",
        "output": "201"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(CN)cc1.CCN(CC)CC.CCO.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.ClCCl.Cn1cc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1C(=O)O.F[B-](F)(F)F>>Cn1cc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1C(=O)NCc1ccc(CNC(=O)OC(C)(C)C)cc1",
        "output": "905"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(C)c1nc(Cl)nc2c1CCCC2c1ccccc1.COc1cc(N)ccc1-n1cnc(Cl)c1.[H-].[Na+]>>CCN(C)c1nc(Nc2ccc(-n3cnc(Cl)c3)c(OC)c2)nc2c1CCCC2c1ccccc1",
        "output": "808"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC[SiH](CC)CC.O=C(O)C(F)(F)F.O=C1Cc2cc(C(=O)CCl)c(Cl)cc2N1>>O=C1Cc2cc(CCCl)c(Cl)cc2N1",
        "output": "92"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.O.O=C([O-])[O-].Oc1cc(Br)cc(-c2ccc3nonc3c2)c1.[K+].[K+]>>COc1cc(Br)cc(-c2ccc3nonc3c2)c1",
        "output": "62"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.ClCCl.Nc1ccc(Nc2nccs2)cc1.O=C(Cl)c1ccccc1>>O=C(Nc1ccc(Nc2nccs2)cc1)c1ccccc1",
        "output": "11"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.NC1CCC1.O=S(=O)(c1ccc(Br)cc1)N1CCC2(CC1)CO2.[Al]>>O=S(=O)(c1ccc(Br)cc1)N1CCC(O)(CNC2CCC2)CC1",
        "output": "16"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CC[C@H](CO)Cc1ccc(F)cc1F.CS(=O)(=O)Cl.ClCCl>>CC[C@H](COS(C)(=O)=O)Cc1ccc(F)cc1F",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1ccc(Br)cc1.C1CCOC1.CCOC(C)=O.COCCO.O.[H-].[Na+]>>COCCOCc1ccc(Br)cc1",
        "output": "464"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(O)c1ccc(-c2cccnc2)cc1.O=C(OO)c1cccc(Cl)c1>>O=C(O)c1ccc(-c2ccc[n+]([O-])c2)cc1",
        "output": "262"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCC(=O)[O-].O.[Na+]>>CCCCCCCC(=O)O",
        "output": "151"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NC(CO)C(C)(C)c1ccccc1.CCOC(=O)N=NC(=O)OCC.CO.O=C1NC(=O)c2ccccc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)NC(CN1C(=O)c2ccccc2C1=O)C(C)(C)c1ccccc1",
        "output": "420"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)O)cc1[N+](=O)[O-].ClCCl.Nc1nccs1.O=C1CCC(=O)N1Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CS(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)Nc2nccs2)cc1[N+](=O)[O-]",
        "output": "681"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.CCOC(=O)CBr.N#Cc1ccc(N=Nc2ccc(O)cc2)cc1.O=C([O-])[O-].[Ca+2].[Cl-].[Cl-].[K+].[K+]>>CCOC(=O)COc1ccc(N=Nc2ccc(C#N)cc2)cc1",
        "output": "123"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)C1CC(=O)N(c2ccc(OCc3ccccc3)cc2)C1.[Pd]>>COC(=O)C1CC(=O)N(c2ccc(O)cc2)C1",
        "output": "698"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)Nc1nc2ccc(OC)cc2nc1OC.Clc1cccc(N2CCNCC2)c1>>COc1ccc2nc(NC(=O)N3CCN(c4cccc(Cl)c4)CC3)c(OC)nc2c1",
        "output": "613"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)CC1.CN(C)C=O.CN(C)CCCl.[H-].[Na+]>>CN(C)CCOC1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "308"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(=O)COc1ccc(Br)cc1OCC.CCOCC.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)COc1ccc(B2OC(C)(C)C(C)(C)O2)cc1OCC",
        "output": "942"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN.Cc1ccc(S(=O)(=O)OCC2Cc3cccc(-c4ccc(Cl)cc4Cl)c3O2)cc1>>CNCC1Cc2cccc(-c3ccc(Cl)cc3Cl)c2O1",
        "output": "853"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCC(=O)c1c(-c2ccc3c(Br)c(OCC#N)ccc3c2)oc2ccc(Cl)cc12.CN(C)C=O.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>CCCCC(=O)c1c(-c2ccc3c(Br)c(OCc4nnn[nH]4)ccc3c2)oc2ccc(Cl)cc12",
        "output": "366"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CC2(CCO1)CO2.CCc1cn2c(N)c(Cl)cc(C(=O)NCC3CCNCC3)c2n1>>CCc1cn2c(N)c(Cl)cc(C(=O)NCC3CCN(CC4(O)CCOCC4)CC3)c2n1",
        "output": "76"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CNC(=O)c1c2cc(C3CC3)c(N(CCO)S(C)(=O)=O)cc2nn1-c1ccc(C)cn1.ClCCl>>CNC(=O)c1c2cc(C3CC3)c(N(CC=O)S(C)(=O)=O)cc2nn1-c1ccc(C)cn1",
        "output": "142"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1cncc(Br)c1.CC(C)(C)OC(=O)N1CCNCC1.CC(C)(C)[O-].Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)OC(=O)N1CCN(c2cncc(Br)c2)CC1",
        "output": "597"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNCC1.O=C(O)c1ccc([N+](=O)[O-])c([N+](=O)[O-])c1>>O=C(c1ccc([N+](=O)[O-])c([N+](=O)[O-])c1)N1CCCCC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](Br)C[C@]4(C)[C@H]3CC[C@]12C.O.c1ccncc1>>CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@H](CC[C@]4(C)[C@@H](C(C)=O)CC[C@@H]34)[C@@]2(C)C[C@@H]1Br",
        "output": "254"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc2c(cnc3[nH]ncc32)c1.C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc3c(cnc4[nH]ncc43)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.ClCc1ccc2ccccc2n1.O.O=C([O-])[O-].Oc1ccc2[nH]ccc2c1.[K+].[K+]>>c1ccc2nc(COc3ccc4[nH]ccc4c3)ccc2c1",
        "output": "616"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@]1(C)c3cc(C(=O)O)c(O)cc3S(=O)C[C@@H]12.CCN(C(C)C)C(C)C.CCOC(C)=O.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F>>CNC(=O)c1cc2c(cc1O)S(=O)C[C@H]1[C@@]2(C)CC[C@H]2C(C)(C)CCC[C@@]21C",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)Oc1c(C(C)(C)C)cc2c(c1C(C)(C)C)CC(C)(COc1ccc(C=NNC(=N)N)cc1)O2.[Cl-].[Li]CCCC.[NH4+]>>CC1(COc2ccc(C=NNC(=N)N)cc2)Cc2c(cc(C(C)(C)C)c(O)c2C(C)(C)C)O1",
        "output": "22"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCN(CCC(O)c3ccc(Br)cc3)CC2)c1.Cc1cccc(O)c1>>Cc1cccc(OC(CCN2CCC(c3cccc(NC(=O)C(C)C)c3)CC2)c2ccc(Br)cc2)c1",
        "output": "342"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cc(C)cc(OC)c1.I>>Cc1cc(O)cc(O)c1",
        "output": "20"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)Oc2ccc([N+](=O)[O-])cc2)CC1.CCOCC.CN(C)C=O.c1cc(C2CCNCC2)ccn1>>CC(C)(C)OC(=O)N1CCN(C(=O)N2CCC(c3ccncc3)CC2)CC1",
        "output": "770"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CC1CCCC1.COc1cc(C(=O)NS(=O)(=O)c2ccccc2S(N)(=O)=O)cnc1Cl>>COc1cc(C(=O)NS(=O)(=O)c2ccccc2S(N)(=O)=O)cnc1C#CC1CCCC1",
        "output": "818"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCOC(=O)Cl.Cc1c(CN)[nH]c2ccccc2c1=O.Cl.Cl.c1ccncc1>>CCCCCOC(=O)NCc1[nH]c2ccccc2c(=O)c1C",
        "output": "94"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)[O-].Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1.O=[N+]([O-])c1cccnc1Cl.[Na+]>>O=[N+]([O-])c1cccnc1Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1",
        "output": "434"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.CC(=O)N(C)C.Nc1cc(Cl)c(Cl)cn1>>Nc1cc(N2CCOCC2)c(Cl)cn1",
        "output": "398"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cc([N+](=O)[O-])c(NC(=O)OC(C)(C)C)cc1N1CCCC1.[Pd]>>Cc1cc(N)c(NC(=O)OC(C)(C)C)cc1N1CCCC1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CN1CC[NH+](C)C1Cl.COc1c(C)c(Cc2ccc(-c3cccnc3)c(C(=O)O)c2)c(OC)c(OC)c1OC.ClCCl.Nc1ccc(C(F)(F)F)cc1.[Cl-]>>COc1c(C)c(Cc2ccc(-c3cccnc3)c(C(=O)Nc3ccc(C(F)(F)F)cc3)c2)c(OC)c(OC)c1OC",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.Cc1sc2cc(C3=NCC4(CCNCC4)S3)[nH]c2c1N(C)S(=O)(=O)c1cccs1>>CC(=O)N1CCC2(CC1)CN=C(c1cc3sc(C)c(N(C)S(=O)(=O)c4cccs4)c3[nH]1)S2",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COc1ccc([N+](=O)[O-])cc1I.O.[Cl-].[Fe].[NH4+]>>COc1ccc(N)cc1I",
        "output": "202"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.Nc1ccncc1.O.O.O=C(O)c1cc(Cl)ccn1.On1nnc2ccccc21>>O=C(Nc1ccncc1)c1cc(Cl)ccn1",
        "output": "548"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cc1ncc(-c2cccc(N)c2)n1C.Cl.ClCCl.O=C(O)c1cccc2c1[nH]c1ccc(F)cc12>>Cc1ncc(-c2cccc(NC(=O)c3cccc4c3[nH]c3ccc(F)cc34)c2)n1C",
        "output": "739"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#C[C@@]1(O)CN2CCC1CC2.CCN(CC)CC.CO.F[C@@H]1CN(c2ccc(I)c(Cc3ccccc3)n2)C[C@H]1F.N.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>O[C@]1(C#Cc2ccc(N3C[C@@H](F)[C@H](F)C3)nc2Cc2ccccc2)CN2CCC1CC2",
        "output": "819"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1ccnnc1.O=C(O)c1cc(Br)ccc1OCc1ccc(F)c(F)c1>>O=C(Nc1ccnnc1)c1cc(Br)ccc1OCc1ccc(F)c(F)c1",
        "output": "759"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1C(=O)COc2ccc(C(O)CN3CC=C(c4c[nH]c5ncccc45)CC3)cc21.Cc1ccc2c(N3CCN(CC(=O)c4ccc5c(c4)NC(=O)CO5)CC3)c(F)ccc2n1>>Cc1ccc2c(N3CCN(CC(O)c4ccc5c(c4)NC(=O)CO5)CC3)c(F)ccc2n1",
        "output": "24"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCc1ccc(C(=O)Cl)cc1.CCN(CC)CC.Cc1nc2c(Cl)c(N)ccc2s1>>CCCc1ccc(C(=O)Nc2ccc3sc(C)nc3c2Cl)cc1",
        "output": "11"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCOc1cc(I)ccc1CO.CS(C)=O.O=C(Cl)C(=O)Cl>>CCCOc1cc(I)ccc1C=O",
        "output": "179"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.ClCCl.O=C(O)C1CC1.O=[N+]([O-])c1cnc(N2CCNCC2)c2ccccc12>>O=C(C1CC1)N1CCN(c2ncc([N+](=O)[O-])c3ccccc23)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CCOC(=O)Cc1ccc(OC)c(Oc2ccc(C(=O)O)cc2CSC(C)(C)C)c1>>CCOC(=O)Cc1ccc(OC)c(Oc2ccc(C(=O)N3CCCCC3)cc2CSC(C)(C)C)c1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[P-](F)(F)(F)(F)F.NCc1nc2ccccc2[nH]1.O=C(O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1>>O=C(NCc1nc2ccccc2[nH]1)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cn1nc(-c2ccc(OC(F)(F)F)cc2)cc1CC#N.O.[Na+].[OH-]>>Cn1nc(-c2ccc(OC(F)(F)F)cc2)cc1CC(=O)O",
        "output": "259"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNC1.CS(C)=O.O=C(NCCCl)Nc1ccc(Oc2cccc(NC(=O)N3CCN(c4ccc(F)cc4)C3=O)c2)cn1>>O=C(NCCN1CCCC1)Nc1ccc(Oc2cccc(NC(=O)N3CCN(c4ccc(F)cc4)C3=O)c2)cn1",
        "output": "138"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(CC)C(=O)Cl.CCC(CC)C(=O)N(c1ccccc1)C1CCN(c2ccc(N)cc2F)CC1.ClCCl>>CCC(CC)C(=O)Nc1ccc(N2CCC(N(C(=O)C(CC)CC)c3ccccc3)CC2)c(F)c1",
        "output": "9"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CNc1cc(C(=O)OC)cc([N+](=O)[O-])c1.CO.[Pd]>>CNc1cc(N)cc(C(=O)OC)c1",
        "output": "481"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)CC(=O)O.Cc1c(CN2CCNCC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12.Cl>>Cc1c(CN2CCN(C(=O)CS(C)(=O)=O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCOCC.Cc1c(F)cccc1Cc1c(-c2ccccc2)c2ccccn2c1C(=O)N1CCN(C(=O)OC(C)(C)C)[C@@H](CCO)C1.ClCCl>>Cc1c(F)cccc1Cc1c(-c2ccccc2)c2ccccn2c1C(=O)N1CCN(C(=O)OC(C)(C)C)[C@@H](CC=O)C1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=C(O)Cc1ccc(F)cc1>>COC(=O)Cc1ccc(F)cc1",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)OB(c2cn[nH]c2)OC1(C)C.CCO.CO.Cc1ccccc1.NC(=O)CC(c1ccc(Br)cc1)c1ccc(Cl)c(F)c1.O.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>NC(=O)CC(c1ccc(-c2cn[nH]c2)cc1)c1ccc(Cl)c(F)c1",
        "output": "971"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.COc1cc(C=O)c(F)cc1Br.ClCCl>>O=Cc1cc(O)c(Br)cc1F",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc(C(F)(F)F)ccc1C(=O)O.Cc1cc(Oc2cc(F)cc(CN)c2)ccc1OC(C)(C)C(=O)O>>COc1cc(C(F)(F)F)ccc1C(=O)NCc1cc(F)cc(Oc2ccc(OC(C)(C)C(=O)O)c(C)c2)c1",
        "output": "753"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Cl.Nc1cc(F)c(F)c(F)c1>>COc1ccc2nc(Nc3cc(F)c(F)c(F)c3)c3n[nH]cc3c2c1",
        "output": "998"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)c1ccncc1.Cl.Cl.FC(F)(F)Oc1cccc(C2COC3(CCNCC3)C2)c1.O>>CC(C)(C)OC(=O)N1CCC2(CC1)CC(c1cccc(OC(F)(F)F)c1)CO2",
        "output": "694"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)COC(=O)Cl.Cc1c(N2CCNCC2)nc2cc(F)cc(F)c2c1Nc1cncc(N2CCOCC2)c1>>Cc1c(N2CCN(C(=O)OCC(C)(C)C)CC2)nc2cc(F)cc(F)c2c1Nc1cncc(N2CCOCC2)c1",
        "output": "219"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CS(=O)(=O)c1ccc(Oc2ncnc3c2cnn3C2CCNCC2)cc1.Clc1ccc(Cl)nn1.O=C(O)C(F)(F)F.O=C([O-])[O-].[Cl-].[K+].[K+].[NH4+]>>CS(=O)(=O)c1ccc(Oc2ncnc3c2cnn3C2CCN(c3ccc(Cl)nn3)CC2)cc1",
        "output": "406"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C(=O)Cl.C[Si](C)(C)C#N.ClCCl.O=C([O-])[O-].[Na+].[Na+].[O-][n+]1ccccc1CO[C@H]1CCOC1>>N#Cc1cccc(CO[C@H]2CCOC2)n1",
        "output": "720"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.FC(F)(F)c1ccccc1[C@@H]1CCNC1.F[P-](F)(F)(F)(F)F.O=C(O)c1cccc(Br)n1>>O=C(c1cccc(Br)n1)N1CC[C@@H](c2ccccc2C(F)(F)F)C1",
        "output": "605"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)CCN(C)c1nc2ccc(NC(=O)c3cnc(Cl)cn3)cc2s1.OB(O)c1ccc(Cl)cc1Cl>>CN(C)CCN(C)c1nc2ccc(NC(=O)c3cnc(-c4ccc(Cl)cc4Cl)cn3)cc2s1",
        "output": "875"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrC1CCC1.CCCc1nc(C)n(-c2ccc(O)c(F)c2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CN(C)C=O.O.O=C([O-])[O-].[Cs+].[Cs+]>>CCCc1nc(C)n(-c2ccc(OC3CCC3)c(F)c2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "153"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCCCN(Cc1ccc(OCc2ccccc2)cc1)C(=O)COc1ccc(C[C@H](OCC)C(=O)OCC)cc1.O.[K+].[Li+].[OH-].[OH-]>>CCCCN(Cc1ccc(OCc2ccccc2)cc1)C(=O)COc1ccc(C[C@H](OCC)C(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)C(Cc1cccc(OCCc2ccc(OS(C)(=O)=O)cc2)c1)OCC.O.O.[Li+].[OH-]>>CCOC(Cc1cccc(OCCc2ccc(OS(C)(=O)=O)cc2)c1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(CC(=O)O)C(=O)OC(C)(C)C.NC(=O)c1c(N)ncn1CCc1ccccc1>>CN(CC(=O)Nc1ncn(CCc2ccccc2)c1C(N)=O)C(=O)OC(C)(C)C",
        "output": "692"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.Cc1ccc(N)c2[nH]cc(C#N)c12.N#Cc1cccc(S(=O)(=O)Cl)c1.c1ccncc1>>Cc1ccc(NS(=O)(=O)c2cccc(C#N)c2)c2[nH]cc(C#N)c12",
        "output": "554"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)CC(Cn2ncc3cc(-c4cnn(C5CCCCO5)c4)ccc32)CN1.CCN(CC)CC.ClCCl.O=C(Cl)CCc1ccccc1.O=C([O-])O.[Na+]>>CC1(C)CC(Cn2ncc3cc(-c4cnn(C5CCCCO5)c4)ccc32)CN1C(=O)CCc1ccccc1",
        "output": "125"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCOc1ccc2c(c1OCCCCC)CN(CCc1ccc([N+](=O)[O-])cc1)C2=O.CCO.[C].[H][H].[Pd]>>CCCCCOc1ccc2c(c1OCCCCC)CN(CCc1ccc(N)cc1)C2=O",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CCCCCOc1ccc2c(c1)[nH]c1ccccc12.CO.[Li+].[OH-]>>O=C(O)CCCCCOc1ccc2c(c1)[nH]c1ccccc12",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N.O.O=C(O)COc1cncc(N2CCc3cc(Cl)ccc3C2=O)c1>>NC(=O)COc1cncc(N2CCc3cc(Cl)ccc3C2=O)c1",
        "output": "313"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.ClCCl.N#Cc1cc(Br)ccc1OC1CCCOC1.[K+]>>CC1(C)OB(c2ccc(OC3CCCOC3)c(C#N)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.COc1cc(Br)c(OC)c(-c2coc3cc(O)ccc3c2=O)c1.ClCCl>>O=c1c(-c2cc(O)cc(Br)c2O)coc2cc(O)ccc12",
        "output": "20"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cc(-c2ccc(OC(F)(F)F)cc2)nn1C.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cn1nc(-c2ccc(OC(F)(F)F)cc2)cc1CO",
        "output": "391"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CNCCCCS(=O)(=O)CCC(F)(F)F.Oc1ccc2c(c1)CCCC(c1ccccc1)=C2CCCCCBr>>CN(CCCCCC1=C(c2ccccc2)CCCc2cc(O)ccc21)CCCCS(=O)(=O)CCC(F)(F)F",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CN(CC)C(=O)NCc2ccc(Cl)cc2)c1.CO.Cl.[Li+].[OH-]>>CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)NCc1ccc(Cl)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc2[nH]c(SCc3ncc(C)c(OC)c3C)nc2c1.ClCCl.O=C(OO)c1cccc(Cl)c1.[NH4+].[OH-]>>COc1ccc2[nH]c(S(=O)Cc3ncc(C)c(OC)c3C)nc2c1",
        "output": "595"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.CC(=O)c1ccc(O)cc1.CCN(C(C)C)C(C)C.ClCCl>>CC(=O)Oc1ccc(C(C)=O)cc1",
        "output": "111"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Br.COc1cc(CC(=O)O)c(OC)cc1C>>Cc1cc(O)c(CC(=O)O)cc1O",
        "output": "20"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Nc1cnc(Cl)cc1C(=O)O.ClCCl.O.O=C(O)C(F)(F)F>>Nc1cnc(Cl)cc1C(=O)O",
        "output": "877"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCO.O.O.O.O.O=C(O)c1ccc(O)cc1.O=S(=O)(O)O.[Co+2].[Na+].[OH-]>>CCOc1ccc(C(=O)O)cc1",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1ccc(Br)cn1.OB(O)c1ccccc1>>Nc1ccc(-c2ccccc2)cn1",
        "output": "833"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCN(CC)C(=O)CNc1cc([N+](=O)[O-])ccc1OC.O.[Fe]>>CCN(CC)C(=O)CNc1cc(N)ccc1OC",
        "output": "202"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCc2cc(Br)c(C(F)F)cc21.Cl[Pd]Cl.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.O.O=C([O-])[O-].[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cn1cc(-c2cc3c(cc2C(F)F)N(C(=O)OC(C)(C)C)CC3)cn1",
        "output": "971"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.NCCN1CCCCC1.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c(F)c1.[K+].[K+]>>O=[N+]([O-])c1ccc(NCCN2CCCCC2)c(F)c1",
        "output": "572"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.ClCCCCCCCCCl.O=S(=O)([O-])O.Oc1ccccc1.[Na+].[OH-]>>ClCCCCCCCCOc1ccccc1",
        "output": "74"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.CCN=C=NCCCN(C)C.CCO.CN(C)C=O.Cl.On1nnc2ccccc21>>CCOC(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)OCC1c2ccccc2-c2ccccc21",
        "output": "47"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.CC#N.Nc1ccc([N+](=O)[O-])cc1O>>Nc1c(O)cc([N+](=O)[O-])cc1Br",
        "output": "98"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)CBr.CCOC(=O)c1ccccc1-c1ccccc1-c1cc(Cl)ccc1O>>CCOC(=O)c1ccccc1-c1ccccc1-c1cc(Cl)ccc1OCC(C)C",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(c1ccc2c(c1)CCO2)c1cc(Br)ccc1Cl.[BH4-].[Na+]>>OC(c1ccc2c(c1)CCO2)c1cc(Br)ccc1Cl",
        "output": "157"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CS(=O)(=O)CCN1CCC(N)CC1.Cl.Cl.O=S(=O)(Cl)c1ccc(Nc2nccc(Nc3ccc(F)cc3)n2)cc1>>CS(=O)(=O)CCN1CCC(NS(=O)(=O)c2ccc(Nc3nccc(Nc4ccc(F)cc4)n3)cc2)CC1",
        "output": "43"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.COc1ccc(Br)c(-c2ccc(N(C)C)cc2)n1.Cc1ccccc1.FC(F)(F)c1ccc(C2CNCCO2)cc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(O)C(=O)O.[Na+].[Pd].[Pd]>>COc1ccc(N2CCOC(c3ccc(C(F)(F)F)cc3)C2)c(-c2ccc(N(C)C)cc2)n1",
        "output": "597"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCCc1cnc(-c2ccc(O)cc2)nc1.FC(F)(COCCCCCCBr)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>CCCCCCCCc1cnc(-c2ccc(OCCCCCCOCC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc2)nc1",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)N(C)C.CN(C)C=O.Cc1cc(C(=O)O)c(C(F)(F)F)o1.Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)c1.O=C(Cl)C(=O)Cl>>Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)c2)c(C(F)(F)F)o1",
        "output": "799"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1c(CC)nn(C2CCSCC2)c1N.CO.O.O.[Li+].[OH-]>>CCc1nn(C2CCSCC2)c(N)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C1Cc2cc(S(=O)(=O)N3CCc4ccccc43)ccc2N1.O=Cc1[nH]cc2c1CCOC2=O>>O=C1Nc2ccc(S(=O)(=O)N3CCc4ccccc43)cc2C1=Cc1[nH]cc2c1CCOC2=O",
        "output": "440"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1cccc(O[Si](C)(C)C(C)(C)C)c1.CCOCC.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.O=S([O-])([O-])=S.[Br-].[Br-].[Br-].[Na+].[Na+]>>CC(C)(C)[Si](C)(C)Oc1cccc(C(=O)CBr)c1",
        "output": "360"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Cl.CC(=O)c1cnc(N2CCn3c(cc4cc(CO)c(S(C)(=O)=O)cc43)C2C(C)C)nc1C(F)(F)F.ClCCl.c1ccncc1>>CC(=O)OCc1cc2cc3n(c2cc1S(C)(=O)=O)CCN(c1ncc(C(C)=O)c(C(F)(F)F)n1)C3C(C)C",
        "output": "126"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCCc1cc2ccccc2c(Oc2ccc(/C=C/C(=O)OCC)cc2)c1-c1ccc(OC)cc1.CCO.[Na+].[OH-]>>CCCCc1cc2ccccc2c(Oc2ccc(/C=C/C(=O)O)cc2)c1-c1ccc(OC)cc1",
        "output": "122"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=c1[nH]c(Cl)cc2ccccc12.OCC1CNCCN1Cc1ccccc1>>O=c1[nH]c(N2CCN(Cc3ccccc3)C(CO)C2)cc2ccccc12",
        "output": "220"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)/C(=N/OC1CCCCC1)c1ccc(S(C)(=O)=O)c(Cl)c1.[Li+].[OH-]>>CS(=O)(=O)c1ccc(/C(=N\\OC2CCCCC2)C(=O)O)cc1Cl",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CO.COC(=O)[C@@H]1C[C@H]1CN1CCN(c2csc3cc(C(F)(F)F)ccc23)CC1.[Na+].[OH-]>>O=C(O)[C@@H]1C[C@H]1CN1CCN(c2csc3cc(C(F)(F)F)ccc23)CC1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.C=C1CCN(Cc2ccccc2)Cc2ccc(Cl)nc21.CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>C=C1CCN(Cc2ccccc2)Cc2ccc(N3CCOCC3)nc21",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(C)(C)Oc1ccc(OCCc2nc(-c3cccc(-c4ccc(F)cc4)c3)oc2C)cc1.CO.[Na+].[OH-]>>Cc1oc(-c2cccc(-c3ccc(F)cc3)c2)nc1CCOc1ccc(OC(C)(C)C(=O)O)cc1",
        "output": "192"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CCN.O=CC1CC1>>CC(C)CCNCC1CC1",
        "output": "426"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NC1CCNC1.CCN(CC)CC.CN(C)C=O.O.O=c1c2cc(F)c(Cl)cc2n(C2CC2)c(=O)n1OCc1ccccc1>>CC(C)(C)OC(=O)NC1CCN(c2cc3c(cc2F)c(=O)n(OCc2ccccc2)c(=O)n3C2CC2)C1",
        "output": "280"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CCOC(=O)Cc1cccc(O)c1.CCOCC.COc1cccc(OC)c1CO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)Cc1cccc(OCc2c(OC)cccc2OC)c1",
        "output": "347"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCO.CCn1c(=O)c2c(nc(/C=C/c3ccc(C(=O)OC)cc3OC)n2C)n(CC)c1=O.Cl.O.O.[Li+].[OH-]>>CCn1c(=O)c2c(nc(/C=C/c3ccc(C(=O)O)cc3OC)n2C)n(CC)c1=O",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.NC(=O)Nc1cn(-c2ccc(Br)c(F)c2)nc1C(N)=O.OB(O)c1ccc(O)cc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>NC(=O)Nc1cn(-c2ccc(-c3ccc(O)cc3)c(F)c2)nc1C(N)=O",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)CCc1ccc(OCCN2CCOCC2)cc1Oc1ncc(C(F)(F)F)cc1Cl.CCOCC.CO.Cc1ccccc1.O.[H-]>>OCCCc1ccc(OCCN2CCOCC2)cc1Oc1ncc(C(F)(F)F)cc1Cl",
        "output": "225"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.O=C([O-])[O-].O=C1CCC1.[Na+].[Na+].[Na+].c1ccc(COc2ccc3c(c2)CCNCC3)cc1>>c1ccc(COc2ccc3c(c2)CCN(C2CCC2)CC3)cc1",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)NCCO[C@H]1COc2ccc3cnn(C[C@@H](C)O[Si](C)(C)C(C)(C)C)c3c2C1.CCCC[N+](CCCC)(CCCC)CCCC.O=C([O-])O.[F-].[Na+]>>CC(=O)NCCO[C@H]1COc2ccc3cnn(C[C@@H](C)O)c3c2C1",
        "output": "708"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCNCC.CCO.CN1CC(CCCl)Oc2ncccc2C1=S>>CCN(CC)CCC1CN(C)C(=S)c2cccnc2O1",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN.O=C(O)C1(c2cccc(Br)n2)CC1>>CNC(=O)C1(c2cccc(Br)n2)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(=O)(=O)c1ccc2c(C(=O)c3ccc(F)cc3)c(O)ccc2c1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=S(=O)([O-])O.[Na+].c1ccncc1>>CS(=O)(=O)c1ccc2c(C(=O)c3ccc(F)cc3)c(OS(=O)(=O)C(F)(F)F)ccc2c1",
        "output": "731"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCC.CCO.CCOC(C)=O.COc1ccc([N+](=O)[O-])cc1-c1c(Br)cnn1C.Cl[Sn]Cl.O.O>>COc1ccc(N)cc1-c1c(Br)cnn1C",
        "output": "202"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "FC(F)(Cl)c1nnc2ccc(Cl)nn12.c1csc(CN2CCNCC2)c1>>FC(F)(Cl)c1nnc2ccc(N3CCN(Cc4cccs4)CC3)nn12",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(N)CN.CCOC(=O)Cc1ccccc1.CCOC(C)=O.NCCN>>NCCNC(=O)Cc1ccccc1",
        "output": "64"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrBr.CC(=O)O.CCO.CCOC(=O)CCC(C)=O>>CCOC(=O)CCC(=O)CBr",
        "output": "173"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)CCCCCCc1nc2c(F)c(F)cc(F)c2s1.O.[Na+].[OH-]>>O=C(O)CCCCCCc1nc2c(F)c(F)cc(F)c2s1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CC(=O)Cl.CCCc1c(CNC)oc2ccccc12.CCN(CC)CC.ClCCl>>C=CC(=O)N(C)Cc1oc2ccccc2c1CCC",
        "output": "135"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCn1nccc1-c1cc(C(=O)OC)oc1C.O=C1CCC(=O)N1Cl>>CCn1ncc(Cl)c1-c1cc(C(=O)OC)oc1C",
        "output": "856"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COc1cc(F)c(-c2ccccc2)cc1C(=O)O.Cl.ClCCl.NCc1cccc([N+](=O)[O-])c1.O=C(Cl)C(=O)Cl>>COc1cc(F)c(-c2ccccc2)cc1C(=O)NCc1cccc([N+](=O)[O-])c1",
        "output": "753"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C=O)c1ccccc1.[H][H].[Na+].[OH-].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(CO)c1ccccc1",
        "output": "223"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1nc(N[C@H](C)C2CC2)c2c(n1)nc(-c1cc(C)ccc1OCCC(=O)NCCO)n2Cc1ccc(Cl)cc1.[Li+].[OH-]>>Cc1ccc(OCCC(=O)NCCO)c(-c2nc3nc(C(=O)O)nc(N[C@H](C)C4CC4)c3n2Cc2ccc(Cl)cc2)c1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CCCN.Cc1[nH]c2c(c1C(=O)O)CCCC2=O>>CCN(CC)CCCNC(=O)c1c(C)[nH]c2c1CCCC2=O",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)O[C@H]2[C@@H](CCn3nnc4ccccc4c3=O)[C@H](/C=C/c3ccc(Br)cc3)O[C@H]2O1.COc1ccc(B(O)O)cc1.O=C([O-])[O-].[K+].[K+]>>COc1ccc(-c2ccc(/C=C/[C@@H]3O[C@H]4OC(C)(C)O[C@H]4[C@H]3CCn3nnc4ccccc4c3=O)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1ccccn1.C#CCCc1nc2c(F)ccc(Cl)c2s1>>Fc1ccc(Cl)c2sc(CCC#Cc3ccccn3)nc12",
        "output": "777"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=O.COc1nc(SCCN)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl.ClCCl>>CCNC(=O)NCCSc1cnc(NS(=O)(=O)c2cccc(Cl)c2Cl)c(OC)n1",
        "output": "244"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCn1nc(-c2ccccn2)cc1-c1ccc2c(c1)cc(-c1c(F)cccc1F)n2S(=O)(=O)c1ccccc1.CO.O=C([O-])[O-].[Cs+].[Cs+]>>CCn1nc(-c2ccccn2)cc1-c1ccc2[nH]c(-c3c(F)cccc3F)cc2c1",
        "output": "771"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1cc(-c2ccncc2)c(C(F)(F)F)nc1N.CO.[Na+].[OH-]>>Nc1nc(C(F)(F)F)c(-c2ccncc2)cc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CNC(=O)c1cccc(F)c1Nc1nc(Cl)ncc1Cl.COCCN1CCCC(C)(C)c2ccc(N)cc21>>CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)N(CCOC)CCCC3(C)C)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cc1cc([N+](=O)[O-])ccc1N1CCOCC1.ClCCl.[Cl-].[NH4+].[Zn]>>Cc1cc(N)ccc1N1CCOCC1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.Cc1cc2cc[nH]c2cc1Br.[BH3-]C#N.[Na+]>>Cc1cc2c(cc1Br)NCC2",
        "output": "672"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)oc1C.Cl.O>>Cc1oc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.C[C@H](C=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C.[BH4-].[Na+]>>C[C@H](CO)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C",
        "output": "223"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#C[Si](C)(C)C.C1CCNCC1.Ic1ccc(OCCN2CCCC2)cc1>>C[Si](C)(C)C#Cc1ccc(OCCN2CCCC2)cc1",
        "output": "826"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cnc2cc(N3CCN(C(=O)OC(C)(C)C)CC3)ccc2c1.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCN(c2ccc3cc(C(=O)O)cnc3c2)CC1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.Nc1ccc(S(=O)(=O)N(c2ccccc2)C2CCN([C@@H]3CCCC[C@@H]3c3ccccc3)CC2)cc1>>CC(=O)Nc1ccc(S(=O)(=O)N(c2ccccc2)C2CCN([C@@H]3CCCC[C@@H]3c3ccccc3)CC2)cc1",
        "output": "6"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(CCCCl)C1OCCO1.CS(C)=O.O.[N-]=[N+]=[N-].[Na+]>>CC(C)(CCCN=[N+]=[N-])C1OCCO1",
        "output": "243"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)C1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C1c2sc(-c3ccc(Cl)cc3)nc2CCN1c1ccc2c(c1)CCN2>>CC(C)(C)OC(=O)N1CCC(C(=O)N2CCc3cc(N4CCc5nc(-c6ccc(Cl)cc6)sc5C4=O)ccc32)C1",
        "output": "315"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc(OC)cc(-c2c(-c3ccccc3F)cnc(C)c2-c2ccc(F)cc2)c1.CSC.ClCCl.O=C(OO)c1cccc(Cl)c1>>COc1cc(OC)cc(-c2c(-c3ccccc3F)c[n+]([O-])c(C)c2-c2ccc(F)cc2)c1",
        "output": "262"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)O)CC2)nc1OC.NS(=O)(=O)Cc1ccc(F)c(F)c1>>CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccc(F)c(F)c3)CC2)nc1OC",
        "output": "644"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(=O)CN1CCNCC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O=C(O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1>>CN(C)C(=O)CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)c1cc(N)cc(-c2cnco2)c1.O=S(=O)(Cl)c1cccc(Cl)c1.c1ccncc1>>CC(C)c1cc(NS(=O)(=O)c2cccc(Cl)c2)cc(-c2cnco2)c1",
        "output": "68"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCOCC.CC[C@@H](CO)NC(=O)OC(C)(C)C.CS(=O)(=O)Cl.O>>CC[C@@H](COS(C)(=O)=O)NC(=O)OC(C)(C)C",
        "output": "0"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.CO.COC(=O)CCCCCCC(=O)O.O.O=C(CBr)c1ccccc1.O=C([O-])O.[Na+]>>COC(=O)CCCCCCC(=O)OCC(=O)c1ccccc1",
        "output": "523"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Cl.CC(=O)OC(C)=O.CCN(CC)CC.COc1nc2ccc(C(O)(c3cnnn3C)C3CNC3)cc2c(Cl)c1Cc1ccc(C(F)(F)F)cc1.ClCCl>>COc1nc2ccc(C(O)(c3cnnn3C)C3CN(C(C)=O)C3)cc2c(Cl)c1Cc1ccc(C(F)(F)F)cc1",
        "output": "125"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)O.C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2nc(-c3ccccn3)nc3sccc23)CN1)C(=O)OC.CC(=O)N(C)C.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+]>>C=CCCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](Oc2nc(-c3ccccn3)nc3sccc23)C[C@H]1C(=O)N[C@]1(C(=O)OC)C[C@H]1C=C",
        "output": "297"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)C(NC(=O)C(NC(=O)c1cnccn1)C1CCCCC1)C(=O)N1C(C(=O)O)CC2CCCCC21.CCCC(N)C(O)C(=O)OCC.CN(C)C=O.CN1CCOCC1.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CCCC(NC(=O)C1CC2CCCCC2N1C(=O)C(NC(=O)C(NC(=O)c1cnccn1)C1CCCCC1)C(C)(C)C)C(O)C(=O)OCC",
        "output": "216"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.CN(C)C=O.Nc1ccc(C(=O)O)cn1.O=C([O-])[O-].[K+].[K+]>>Nc1ccc(C(=O)OCc2ccccc2)cn1",
        "output": "403"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.NCCO>>CC(C)(C)OC(=O)NCCO",
        "output": "631"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCC(=O)c1ccc(-c2ccc(CCC(COC(C)=O)(COC(C)=O)NC(C)=O)cc2)cc1.CC[SiH](CC)CC.O=C(O)C(F)(F)F>>CCCCCCc1ccc(-c2ccc(CCC(COC(C)=O)(COC(C)=O)NC(C)=O)cc2)cc1",
        "output": "92"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COc1ccc(Cl)c(-c2cc3nnc(Nc4ccc(OCCN5CCCC5)cc4)nc3cc2C)c1.ClCCl>>Cc1cc2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2cc1-c1cc(O)ccc1Cl",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CO.O=C1OC(=O)C2CCC12>>COC(=O)C1CCC1C(=O)O",
        "output": "139"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(=O)c1ccc(SC2CC2)cc1.Cc1ccccc1.Cl.[Na+].[OH-]>>O=C(O)C(=O)c1ccc(SC2CC2)cc1",
        "output": "472"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.COc1cc(B2OC(C)(C)C(C)(C)O2)cc(Cl)c1O.Cl[Pd]Cl.O=C([O-])[O-].O=C(c1cnc2ccc(Br)cc2c1Cl)C1CC1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1cc(-c2ccc3ncc(C(=O)C4CC4)c(Cl)c3c2)cc(Cl)c1O",
        "output": "933"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.CO.COc1cc(N2CCC(N3CCN(CCF)CC3)CC2)c(OC)cc1N.Cl.N.O=C(Nc1c(F)cccc1F)c1cccc(-c2nc3ccccn3c2-c2ccnc(Cl)n2)c1>>COc1cc(N2CCC(N3CCN(CCF)CC3)CC2)c(OC)cc1Nc1nccc(-c2c(-c3cccc(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCO.O=c1c(-c2ccc([N+](=O)[O-])cc2)coc2cc(O)c(O)cc12.[Ni]>>Nc1ccc(-c2coc3cc(O)c(O)cc3c2=O)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)CC(O)CO.CCO.CC[O-].Cl.FC(F)(F)c1cccnc1Br.O.[Cu]Br.[Na+]>>CCOc1ncccc1C(F)(F)F",
        "output": "551"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccc2c(N3CCN(C(=O)OC(C)(C)C)CC3)cccc2n1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc2c(N3CCNCC3)cccc2n1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)Cc1cc(OCc2ccc(F)cc2)ccc1I.O.[Li+].[OH-]>>O=C(O)Cc1cc(OCc2ccc(F)cc2)ccc1I",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)OB(c2cnc(N)nc2)OC1(C)C.Cc1c(-c2cccc(O)c2)sc2c(N3CCOCC3)nc(Cl)nc12>>Cc1c(-c2cccc(O)c2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12",
        "output": "973"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCS(=O)(=O)c1cccc(-c2cc(C(=O)O)cc3[nH]c4ncc(C)cc4c23)c1.CN1CCNCC1.ClCCCl.ClCCl.On1nnc2ccccc21>>CCS(=O)(=O)c1cccc(-c2cc(C(=O)N3CCN(C)CC3)cc3[nH]c4ncc(C)cc4c23)c1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C)(C)NCC(=O)c1cc(Cl)c(N)c(C(F)(F)F)c1.Cl.Cl.[BH4-].[Na+]>>CCC(C)(C)NCC(O)c1cc(Cl)c(N)c(C(F)(F)F)c1",
        "output": "24"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.COc1cccc(C2(c3ccncc3)N=C(N)N(C)C2=O)c1.ClCCl>>CN1C(=O)C(c2ccncc2)(c2cccc(O)c2)N=C1N",
        "output": "732"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCn1cc(C[C@H](NC(=O)C=Cc2ccccc2F)C(=O)OC)c2ccccc21.CO.[Na+].[OH-]>>CCCCn1cc(C[C@H](NC(=O)C=Cc2ccccc2F)C(=O)O)c2ccccc21",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)c1cc2c(ncn2CCC(=O)N2CCCC2)c(F)c1Nc1ccc(Br)cc1Cl.Cl.O.[Li+].[OH-]>>O=C(O)c1cc2c(ncn2CCC(=O)N2CCCC2)c(F)c1Nc1ccc(Br)cc1Cl",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(O)CN1CCOCC1.COc1cc(C(=O)O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F>>COc1cc(C(=O)OC(C)CN2CCOCC2)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F",
        "output": "33"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCBr.CC(C)=O.CCCCCC.O=C([O-])[O-].Oc1ccc2c(c1)CC(CCc1ccccc1)O2.[K+].[K+]>>C=CCOc1ccc2c(c1)CC(CCc1ccccc1)O2",
        "output": "77"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CN1CCOCC1.Cl.NO.O.O=C(O)C(CS(=O)(=O)c1ccc(Cl)cc1)CS(=O)(=O)c1ccc(Cl)cc1.On1nnc2ccccc21>>O=C(NO)C(CS(=O)(=O)c1ccc(Cl)cc1)CS(=O)(=O)c1ccc(Cl)cc1",
        "output": "480"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)c1cn(-c2ccnc(Cl)n2)nc1C.Cc1ccccc1.Cc1nn(-c2ccnc(Nc3ccc4c(ccn4C)c3)n2)cc1CN1CC(O)C1.[H-]>>Cc1nn(-c2ccnc(Cl)n2)cc1CO",
        "output": "471"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)c1ccncc1.CS(=O)(=O)N(CCN1CCOCC1)c1cccc2c1ccn2CC(=O)O.ClCCCl.ClCCl.[O-][n+]1cc(Cl)c(C[C@H](O)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1>>CS(=O)(=O)N(CCN1CCOCC1)c1cccc2c1ccn2CC(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN1C(=N)/C(=C\\c2ccc(O)c(OC)c2)N(C)C1=O.CN(C)C=O.FC(F)(F)c1ccccc1CBr.O=C([O-])[O-].[K+].[K+].[Na+].[OH-]>>CCN1C(=N)/C(=C\\c2ccc(OCc3ccccc3C(F)(F)F)c(OC)c2)N(C)C1=O",
        "output": "127"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.CNCCNC.COCCCc1ccc(Br)cc1.O=C1NCCC12CCC1(CC2)OCCO1.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>COCCCc1ccc(N2CCC3(CCC4(CC3)OCCO4)C2=O)cc1",
        "output": "809"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CO.Clc1ccc(C(c2ccc(Cl)cc2)c2ccc3nncc(NC4CCNCC4)c3c2)cc1.O.O=Cc1ccc(C(=O)O)s1.[BH3-]C#N.[Na+]>>O=C(O)c1ccc(CN2CCC(Nc3cnnc4ccc(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)cc34)CC2)s1",
        "output": "792"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)n1nc(N)c2cc([N+](=O)[O-])ccc21.CO>>CC(C)(C)OC(=O)n1nc(N)c2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1c[nH]c(C(N)=O)c1-c1ccc([N+](=O)[O-])cc1.O=S(=O)(O)O>>NC(=O)c1[nH]cc(C(=O)O)c1-c1ccc([N+](=O)[O-])cc1",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.COC1CNC1.Cl.Fc1ccc(Br)cn1.O=C([O-])[O-].[K+].[K+]>>COC1CN(c2ccc(Br)cn2)C1",
        "output": "756"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COCCBr.Oc1ccc2c(c1)OCO2>>COCCOc1ccc2c(c1)OCO2",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccccc1.O=S(Cl)Cl.OCc1cccnc1-c1ccncc1>>ClCc1cccnc1-c1ccncc1",
        "output": "477"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCOC(C)=O.CN(C)Cc1ccc(-c2ccccc2C(O)C(F)(F)F)o1.Nc1nc(Cl)cc(Cl)n1.O=C([O-])[O-].[Cs+].[Cs+]>>CN(C)Cc1ccc(-c2ccccc2C(Oc2cc(Cl)nc(N)n2)C(F)(F)F)o1",
        "output": "653"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#C[Si](C)(C)C.CC(C)(C)OC(=O)COc1cc(Br)cc(OCC(=O)OC(C)(C)C)c1.CCNCC.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)COc1cc(C#C[Si](C)(C)C)cc(OCC(=O)OC(C)(C)C)c1",
        "output": "671"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1.O=C1CCC(c2ccc(N3CCCC3)cc2)CC1>>O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(c3ccc(N4CCCC4)cc3)CC2)C1",
        "output": "187"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)Cn1ccc2cc(N)ccc21.CS(=O)(=O)Cl.c1ccncc1>>COC(=O)Cn1ccc2cc(NS(C)(=O)=O)ccc21",
        "output": "194"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.Cn1cc(-c2ccc(-c3cncc4ccc(C(=O)N5CC(C)(F)C5)cc34)cc2)cn1.O=C(OO)c1cccc(Cl)c1.[Na+].[OH-]>>Cn1cc(-c2ccc(-c3c[n+]([O-])cc4ccc(C(=O)N5CC(C)(F)C5)cc34)cc2)cn1",
        "output": "262"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "N#Cc1cccc(F)c1.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>N#Cc1cc(F)ccc1[N+](=O)[O-]",
        "output": "103"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCCCCC(Nc1ccc(C(=O)OC)cc1)c1cc2cc(Cl)ccc2n1C.CCO.[Na+].[OH-]>>CCCCCCC(Nc1ccc(C(=O)O)cc1)c1cc2cc(Cl)ccc2n1C",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.Cl.F[P-](F)(F)(F)(F)F.N[C@H]1CN2CCC1CC2.O=C(O)c1cc2ccc([N+](=O)[O-])cc2o1>>O=C(N[C@H]1CN2CCC1CC2)c1cc2ccc([N+](=O)[O-])cc2o1",
        "output": "714"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CO1.CC1=C(C(=O)OC(C)(C)C)N2C(=O)[C@@H](N)[C@H]2SC1.ClCCl.O=C(Cl)COc1ccccc1>>CC1=C(C(=O)OC(C)(C)C)N2C(=O)[C@@H](NC(=O)COc3ccccc3)[C@H]2SC1",
        "output": "159"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CC(C)(C)CCN1CCC(C(=O)O)CC1.CCN(CC)CC.CCOC(C)=O.CN(C)c1ccncc1.Cc1nc2c(o1)-c1ccccc1N(C(=O)c1ccc(CN)c(C)c1)CC2.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>Cc1nc2c(o1)-c1ccccc1N(C(=O)c1ccc(CNC(=O)C3CCN(CCC(C)(C)C)CC3)c(C)c1)CC2",
        "output": "599"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC[C@H](NC(=O)c1cc2ccccc2cc1N)C(=O)OC.Cc1cc(C)c(N=C=O)c(C)c1.c1ccncc1>>CCC[C@H](NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C)C(=O)OC",
        "output": "993"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CN.CO.COC(=O)c1cc(Cl)ccn1.Cl>>CNC(=O)c1cc(Cl)ccn1",
        "output": "487"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C(C)(Cc1ccc(OCCC2CN(Cc3cccc(C(F)(F)F)c3)C(=O)N2C)cc1)Oc1ccccc1.Cl.[Na+].[OH-]>>CN1C(=O)N(Cc2cccc(C(F)(F)F)c2)CC1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)O)cc1",
        "output": "192"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=[N+]([O-])c1cnc2ccsc2c1N[C@@H]1CC[C@@H](O)CC1.[Pd]>>Nc1cnc2ccsc2c1N[C@@H]1CC[C@@H](O)CC1",
        "output": "269"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOCC.COC(=O)CC1COc2ccccc2C1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OCCC1COc2ccccc2C1",
        "output": "343"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.CN(C)C=O.O=C(Cl)c1ccc(Br)cc1F>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(Br)cc2F)CC1",
        "output": "201"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COc1cccc(CN)c1F.Cl.Nc1ccc(C(=O)O)c(N)n1.O.On1nnc2ccccc21>>COc1cccc(CNC(=O)c2ccc(N)nc2N)c1F",
        "output": "790"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)/C=C/c1cnc(N[C@@H]2CCN(CCc3cccc(F)c3)C2)cn1.Cl.[Na+].[OH-]>>O=C(O)/C=C/c1cnc(N[C@@H]2CCN(CCc3cccc(F)c3)C2)cn1",
        "output": "58"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNC1.CC(C)(C)c1ccc(C#N)s1.Nc1nc(-c2ccco2)nc2sc(C=O)cc12>>Nc1nc(-c2ccco2)nc2sc(CN3CCCC3)cc12",
        "output": "792"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.Cc1cc(C(=O)O)c(Br)cc1F.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br.O=S([O-])([O-])=S.[Na+].[Na+]>>O=C(O)c1cc(CBr)c(F)cc1Br",
        "output": "29"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.OCc1cn(Cc2cc(OCc3ccccc3)cc(OCc3ccccc3)c2)cc1-c1ccccc1.[Mn+4].[O-2].[O-2]>>O=Cc1cn(Cc2cc(OCc3ccccc3)cc(OCc3ccccc3)c2)cc1-c1ccccc1",
        "output": "520"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.O=C(Cc1ccccc1)c1ccc2[nH]c(=O)c(-c3cccs3)nc2c1.[H][H].[Pd]>>O=c1[nH]c2ccc(CCc3ccccc3)cc2nc1-c1cccs1",
        "output": "92"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)CCNC(=O)c1ccc(N2CCN(C3CCN(C(=O)OCc4ccccc4)CC3)C2=O)cc1.[H][H].[Pd]>>COC(=O)CCNC(=O)c1ccc(N2CCN(C3CCNCC3)C2=O)cc1",
        "output": "428"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)NCCN.CO.Cc1cccc(-c2c(C(=O)O)[nH]c3ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)cc23)c1.ClCCl>>CC(=O)NCCNC(=O)c1[nH]c2ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)cc2c1-c1cccc(C)c1",
        "output": "137"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.ClC(Cl)Cl.FC(F)(F)c1ccc2oc(-c3ccncc3Br)nc2c1.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1ccc(-c2nc3cc(C(F)(F)F)ccc3o2)c(Br)c1",
        "output": "262"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc(N)cc1-n1cnc2ccc(N3CCCN(C)CC3)cc2c1=O.O=C(Cl)c1ccnc(Cl)c1>>Cc1ccc(NC(=O)c2ccnc(Cl)c2)cc1-n1cnc2ccc(N3CCCN(C)CC3)cc2c1=O",
        "output": "11"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.F[C@H]1CCNC1.O=C(NCC1CCC(F)(F)CC1)c1c(Cl)ccc2nc(Cl)ccc12>>O=C(NCC1CCC(F)(F)CC1)c1c(Cl)ccc2nc(N3CC[C@H](F)C3)ccc12",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COCCOC.ClCCl.Cl[Pd]Cl.O=S(=O)(Nc1cc(Br)ccc1Cl)c1ccccc1.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc(Cl)c(NS(=O)(=O)c3ccccc3)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.ClCCl.NCC1CC1.O=C(O)C1CC1.Oc1cccc2[nH]nnc12>>O=C(NCC1CC1)C1CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)Cn1ccc2cc(OCc3nc(-c4ccc(C(F)(F)F)cc4)oc3C)ccc21.CCOCC.Cl.[Na+].[OH-]>>Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1COc1ccc2c(ccn2CC(=O)O)c1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@H](n2c(=O)c3cc(F)cnc3n(-c3cccc(-c4ccc(O)cc4CN4CCOCC4)c3)c2=O)CC1.CO.O=CO>>N[C@@H]1CC[C@H](n2c(=O)c3cc(F)cnc3n(-c3cccc(-c4ccc(O)cc4CN4CCOCC4)c3)c2=O)CC1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC(=O)[O-].Cc1cc(C(=O)O)ccc1Br.Cc1ccccc1B(O)O.O.[Pd+2]>>Cc1ccccc1-c1ccc(C(=O)O)cc1C",
        "output": "837"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(C(C)=O)cc3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.CCO.CCON.Cl.c1ccncc1>>CCON=C(C)c1ccc(Cc2cc([C@@H]3O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(C)=O)ccc2Cl)cc1",
        "output": "212"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)Cc1ccc(S(=O)(=O)c2cc(-c3cccc(Cl)c3)nc3c2CCC3)cc1.N>>NC(=O)Cc1ccc(S(=O)(=O)c2cc(-c3cccc(Cl)c3)nc3c2CCC3)cc1",
        "output": "432"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.CNC.Cc1ccc(C(=O)O)cc1-n1cnc2ccc(OCCCl)cc2c1=O.Cl.ClCCl.[N-]=C=O>>Cc1ccc(C(=O)O)cc1-n1cnc2ccc(OCCN(C)C)cc2c1=O",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-c2ccccc2)n(Cc2ccccc2)c1=O.O.[Na+].[OH-]>>O=C(O)c1ccc(-c2ccccc2)n(Cc2ccccc2)c1=O",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)CCCN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cccc(C)c1NC(=O)Nc1cc2ccccc2cc1C(=O)O.Cl.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+]>>CCOC(=O)CCCNC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cccc1C",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCC(=O)Cl.CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCNCC1.F[P-](F)(F)(F)(F)F>>CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)N2CCN(C)CC2)cc1)c1ccccc1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@@H](C(=O)O)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1ccc(S(=O)(=O)n2ccc3nc(CN)cnc32)cc1.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O>>Cc1ccc(S(=O)(=O)n2ccc3nc(CNC(=O)[C@@H]4CCCN(C(=O)OC(C)(C)C)C4)cnc32)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)C2CC[C@@]1(CS(=O)(=O)O)C(=O)C2.CCO.Cc1ccccc1.Nc1ccc(Oc2cc(NC(=O)N3CCN(CCN4CCC4)CC3)ncn2)c(F)c1.O=C(Cc1ccc(F)cc1)N=C=S>>O=C(Cc1ccc(F)cc1)NC(=S)Nc1ccc(Oc2cc(NC(=O)N3CCN(CCN4CCC4)CC3)ncn2)c(F)c1",
        "output": "961"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#C[C@]1(O)CCN(C)C1=O.NC(=O)c1nc(-c2cc(Br)ccc2F)ncc1N>>CN1CC[C@@](O)(C#Cc2ccc(F)c(-c3ncc(N)c(C(N)=O)n3)c2)C1=O",
        "output": "659"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COc1ccc2[nH]c3c(c2c1)CC(CCCOS(C)(=O)=O)NC3=O.O.[N-]=[N+]=[N-].[Na+]>>COc1ccc2[nH]c3c(c2c1)CC(CCCN=[N+]=[N-])NC3=O",
        "output": "322"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(=O)[C@H](CO)C[C@@H](Cc1ccc(-c2cc(Cl)ccc2F)cc1)NC(=O)OC(C)(C)C.CS(=O)(=O)Cl.ClCCl>>CCOC(=O)[C@H](COS(C)(=O)=O)C[C@@H](Cc1ccc(-c2cc(Cl)ccc2F)cc1)NC(=O)OC(C)(C)C",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.ClCCl.Clc1cnc(SCc2ccccc2)nc1.O=C(OO)c1cccc(Cl)c1>>O=S(Cc1ccccc1)c1ncc(Cl)cn1",
        "output": "595"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C1Nc2ncccc2C12Cc1cc3ccc(O)nc3cc1C2.O=P(Cl)(Cl)Cl>>O=C1Nc2ncccc2C12Cc1cc3ccc(Cl)nc3cc1C2",
        "output": "41"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)CC(c1nc2cc(C#N)ccc2o1)c1c(OC)cc(C)c2[nH]ccc12.O.[Na+].[OH-]>>COc1cc(C)c2[nH]ccc2c1C(CC(=O)O)c1nc2cc(C#N)ccc2o1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.O=C1CCC(=O)N1Br.c1ccc(N(c2ccccc2)c2ccccc2)cc1>>Brc1ccc(N(c2ccccc2)c2ccccc2)cc1",
        "output": "4"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1noc(COc2ccc([N+](=O)[O-])cc2)n1.O=C([O-])[O-].O=S([O-])S(=O)[O-].[K+].[K+].[Na+].[Na+]>>Cc1noc(COc2ccc(N)cc2)n1",
        "output": "202"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COc1ccc(-c2nc3cc(OC)cc(OC)c3c(=O)[nH]2)c(F)c1.C[Si](C)(C)[N-][Si](C)(C)C.NC1CCOCC1.O.[Li+]>>COc1ccc(-c2nc3cc(OC)cc(OC)c3c(=O)[nH]2)c(NC2CCOCC2)c1",
        "output": "572"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOCC.CN(C)C=O.COCOc1cc(OC)c(OCOC)c(CCCI)c1OC.COCOc1cc(OC)c(OCOC)c(CCO)c1OC.[H-].[Na+]>>COCOc1cc(OC)c(OCOC)c(CCCOCCc2c(OC)c(OCOC)cc(OC)c2OCOC)c1OC",
        "output": "307"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.Cn1c(C2OCCCO2)cnc1-c1cc2nccc(Cl)c2s1.O=C([O-])O.O=[N+]([O-])c1ccc(O)c(F)c1.[Na+].c1ccc(Oc2ccccc2)cc1>>Cn1c(C2OCCCO2)cnc1-c1cc2nccc(Oc3ccc([N+](=O)[O-])cc3F)c2s1",
        "output": "936"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCCC(=O)O.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1>>COCCC(=O)N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.C=CCCc1ccccc1Br.CN(C)C=O.[Li]CCCC>>C=CCCc1ccccc1C=O",
        "output": "638"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc(N=C=S)cc(OC)c1.Cc1cn(CCCN)cn1>>COc1cc(NC(=S)NCCCn2cnc(C)c2)cc(OC)c1",
        "output": "113"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.Cc1ccc(C(=O)O)cc1-n1c(C)cc(OCc2ccccc2CNC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(Cl)c(O)c2)c(Cl)c1=O.NCCO>>Cc1ccc(C(=O)NCCO)cc1-n1c(C)cc(OCc2ccccc2CNC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(Cl)c(O)c2)c(Cl)c1=O",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)N(C)C.Cc1ccc(S(=O)(=O)OCCC2CC3CCC(C2)N3C(=O)OC(C)(C)C)cc1.Cn1ccc2c(-c3ccc(O)c(C(F)(F)F)c3)nc(C#N)nc21.O=C([O-])[O-].[K+].[K+]>>Cn1ccc2c(-c3ccc(OCCC4CC5CCC(C4)N5C(=O)OC(C)(C)C)c(C(F)(F)F)c3)nc(C#N)nc21",
        "output": "438"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CC[O-].Nc1nnc2c3c(c(Cl)nn12)CCCC3.[Na+]>>CCOc1nn2c(N)nnc2c2c1CCCC2",
        "output": "407"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.Cc1cc(F)ccc1C(CCO)CN(C)C(=O)c1cc(C#N)cc2c1CCCC2.ClCCl.O=C([O-])O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>Cc1cc(F)ccc1C(CC=O)CN(C)C(=O)c1cc(C#N)cc2c1CCCC2",
        "output": "142"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1cccc(I)c1.CO.O.[BH4-].[Cl-].[NH4+].[Na+]>>CC(O)c1cccc(I)c1",
        "output": "24"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCc1cc(CCC=O)n(-c2ccc(OC(F)(F)F)cc2)n1.Fc1ccccc1N1CCNCC1.[Na+]>>CCCc1cc(CCCN2CCN(c3ccccc3F)CC2)n(-c2ccc(OC(F)(F)F)cc2)n1",
        "output": "484"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(=O)CCC1CC(=O)C1.COc1ccc(CNc2ncnc3c2ccn3[C@@H]2C[C@H](CN)[C@@H](O)[C@H]2O)c(OC)c1.ClCCCl.O=C([O-])O.[Na+].[Na+]>>CCOC(=O)CCC1CC(NC[C@H]2C[C@@H](n3ccc4c(NCc5ccc(OC)cc5OC)ncnc43)[C@H](O)[C@@H]2O)C1",
        "output": "236"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCCCCCN.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NS(=O)(=O)c1cccc(C(=O)O)c1.O=C(O)C(F)(F)F>>C=CCCCCCNC(=O)c1cccc(S(N)(=O)=O)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)c1nc2cc(Br)c(C(F)(F)F)cc2[nH]c1=O.Cl.O.[K+].[OH-]>>O=C(O)c1nc2cc(Br)c(C(F)(F)F)cc2[nH]c1=O",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCN=C=O.CCN(CC)CC.Cl.O=C(Nc1ccc(N2CCNCC2)cc1)c1nc(-c2ccccc2)oc1C(F)(F)F>>CCCNC(=O)N1CCN(c2ccc(NC(=O)c3nc(-c4ccccc4)oc3C(F)(F)F)cc2)CC1",
        "output": "437"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)N=NC(=O)OCC.CN(C)C=O.CN(C)CCO.ClCCl.Nc1ccccc1NC(=O)c1ccc(-c2ncc(O)cc2Cl)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN(C)CCOc1cnc(-c2ccc(C(=O)Nc3ccccc3N)cc2)c(Cl)c1",
        "output": "547"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N1CCCC(c2ccc(C(=O)O)cc2)C1.Cc1cc(N2CCC(N3CCCC3C)C2)ccc1N>>CC(=O)N1CCCC(c2ccc(C(=O)Nc3ccc(N4CCC(N5CCCC5C)C4)cc3C)cc2)C1",
        "output": "50"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrC(Br)(Br)Br.C1CCOC1.Nc1ncnn2c(CCCCO)cc(-c3cccc(OCc4ccccc4)c3)c12.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Nc1ncnn2c(CCCCBr)cc(-c3cccc(OCc4ccccc4)c3)c12",
        "output": "378"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCN(C(=O)Nc2cccc(-c3nc(Nc4ccc5c(cnn5C(=O)OC(C)(C)C)c4)c4ccccc4n3)c2)CC1.ClCCl.O=C(O)C(F)(F)F>>CN1CCN(C(=O)Nc2cccc(-c3nc(Nc4ccc5[nH]ncc5c4)c4ccccc4n3)c2)CC1",
        "output": "896"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CC1(C)CCC[C@]2(C)C(C=O)[C@](C)(O)CC[C@@H]12.COc1cc(N)cc(OC)c1.[Na+]>>COc1cc(NCC2[C@](C)(O)CC[C@H]3C(C)(C)CCC[C@]23C)cc(OC)c1",
        "output": "336"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.CO.COCc1c(-c2ccc(OC(F)F)c(OC3CC3)c2)[nH]c2cnn(COCC[Si](C)(C)C)c(=O)c12.C[O-].[Na+]>>COCc1c(-c2ccc(OC(F)F)c(OC3CC3)c2)[nH]c2cn[nH]c(=O)c12",
        "output": "813"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)OC(=O)C1CNCC(C)(C)c2cc(C#N)[nH]c21.O=C(Cl)c1cccc(Cl)c1>>CC(C)OC(=O)C1CN(C(=O)c2cccc(Cl)c2)CC(C)(C)c2cc(C#N)[nH]c21",
        "output": "201"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NC(N)=O.Nc1ccc(Cl)c(S(=O)(=O)NCCOCc2ccccc2)c1O.O=C=Nc1cccc(Cl)c1Cl>>O=C(Nc1ccc(Cl)c(S(=O)(=O)NCCOCc2ccccc2)c1O)Nc1cccc(Cl)c1Cl",
        "output": "473"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CCO.Cc1[nH]c(C=O)c(C)c1C(=O)NCCO.O=C1Cc2cc(S(=O)(=O)Cc3c(Cl)cccc3Cl)ccc2N1>>Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)NCCO",
        "output": "911"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COCCBr.O.O=C([O-])[O-].Oc1ccc(F)cc1Cl.[K+].[K+]>>COCCOc1ccc(F)cc1Cl",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.NC(=O)c1cc(Cl)cc(CO)c1>>NCc1cc(Cl)cc(CO)c1",
        "output": "215"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.COc1cc(CC(=O)O)ccc1[N+](=O)[O-].[Pd]>>COc1cc(CC(=O)O)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)CCOC1CCCCO1.[Na+].[OH-]>>O=C(O)CCOC1CCCCO1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN[C@H](CCNC(=O)c1ccccn1)Cc1ccccc1.Cl.Cl.ClCCCl.ClCCl.O=C(O)c1cccc(C(F)(F)F)c1.On1nnc2ccccc21>>CN(C(=O)c1cccc(C(F)(F)F)c1)[C@H](CCNC(=O)c1ccccn1)Cc1ccccc1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1cnc2ccc(Cl)cc2c1-c1ccccc1.Cl.O.[K+].[OH-]>>O=C(O)c1cnc2ccc(Cl)cc2c1-c1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.O.O=C(O)C1CCNCC1.[Pd]>>CN1CCC(C(=O)O)CC1",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCNc1nc(Nc2ccncc2)ncc1[N+](=O)[O-].[Pd]>>CCNc1nc(Nc2ccncc2)ncc1N",
        "output": "660"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(Cl)OC(=O)Cl.ClCCCl.Clc1nc(N2CC3CCC(C2)O3)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1.O=C([O-])[O-].[K+].[K+]>>Clc1nc(N2CC3CCC(C2)O3)c2cnn(C3CCNCC3)c2n1",
        "output": "84"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN.CO.Cc1cc(Nc2cc(Cl)nc(N3CCCC3c3cc(-c4ccccn4)no3)n2)n[nH]1>>CNc1cc(Nc2cc(C)[nH]n2)nc(N2CCCC2c2cc(-c3ccccn3)no2)n1",
        "output": "166"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCOC(C)=O.COc1cc(N)ccc1F.Fc1ccc(Oc2ccc(Cl)nc2)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>COc1cc(Nc2ccc(Oc3ccc(F)cc3)cn2)ccc1F",
        "output": "434"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1cccc2cnccc12.COCCOC.O=C([O-])[O-].OB(O)c1ccc(F)cc1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Fc1ccc(-c2cccc3cnccc23)cc1",
        "output": "837"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CS(C)=O.Clc1cc(Cl)cc(CBr)c1.O=C([O-])[O-].O=[N+]([O-])c1ncc[nH]1.[Na+].[Na+]>>O=[N+]([O-])c1nccn1Cc1cc(Cl)cc(Cl)c1",
        "output": "658"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCCCCCNC(=O)CCCCSc1nc(-c2ccccc2)c(-c2ccccc2)[nH]1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCCCCCNCCCCCSc1nc(-c2ccccc2)c(-c2ccccc2)[nH]1",
        "output": "112"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COc1ccc(-n2cccn2)cc1.O=C1CCC(=O)N1Br>>COc1ccc(-n2cc(Br)cn2)cc1",
        "output": "620"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COc1cc2c(cc1O[Si](C(C)C)(C(C)C)C(C)C)CC2(C#N)CCCO.CS(C)=O.O>>COc1cc2c(cc1O[Si](C(C)C)(C(C)C)C(C)C)CC2(C#N)CCC=O",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCN(C2CCNC2)C1.CC1CCCC(O)(CNC(=O)c2c(Cl)ccc3nc(Cl)ccc23)C1.CCN(C(C)C)C(C)C>>CC1CCCC(O)(CNC(=O)c2c(Cl)ccc3nc(N4CCC(N5CCCC5)C4)ccc23)C1",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(=O)(=O)Cl.ClCCl.O.OC1CN(C(c2ccccc2)c2ccccc2)C1>>CS(=O)(=O)OC1CN(C(c2ccccc2)c2ccccc2)C1",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1cnc(N[C@@H]2CC[C@H](N)CC2)nc1N(C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)CS(=O)c1cccc(C(F)(F)F)c1>>Cc1cnc(N[C@@H]2CC[C@H](NC(=O)CS(=O)c3cccc(C(F)(F)F)c3)CC2)nc1N(C)C",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#CCOc1ccc(C=O)c2ccccc12.CC#N.CC[SiH](CC)CC.COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.O=C(O)C(F)(F)F>>CC#CCOc1ccc(CNC(=O)c2c(OC)cc(O)c3c2OC2=CC(O)=C(C(C)=O)C(=O)[C@]23C)c2ccccc12",
        "output": "996"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)S(=O)(=O)Cl.Cn1c(C#N)ccc1-c1ccc(N)cc1C(F)(F)F.O.c1ccncc1>>CC(C)S(=O)(=O)Nc1ccc(-c2ccc(C#N)n2C)c(C(F)(F)F)c1",
        "output": "194"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(=O)C1(c2ccc(-c3ccc(Br)cc3)cc2)CC1>>CCOC(=O)C1(c2ccc(-c3ccc(B4OC(C)(C)C(C)(C)O4)cc3)cc2)CC1",
        "output": "942"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)O.CN(C)C(=O)N1CCc2ccc(N)cc2CC1.CNC(=O)c1ccccc1Nc1nc(Cl)ncc1Cl.Cl>>CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)CCN(C(=O)N(C)C)CC3)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Clc1cc(Cl)cc(I)c1.O=C([O-])[O-].Sc1cc(Cl)cc(Cl)c1.[K+].[K+]>>Clc1cc(Cl)cc(Sc2cc(Cl)cc(Cl)c2)c1",
        "output": "565"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)CCO.O=C(O)COc1ncc(C(=O)Nc2ccc(F)cc2)cn1>>CC(C)(C)CCOC(=O)COc1ncc(C(=O)Nc2ccc(F)cc2)cn1",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCS(=O)(=O)N1CC(O)C1.CS(=O)(=O)Cl.ClCCl.c1ccncc1>>CCCS(=O)(=O)N1CC(OS(C)(=O)=O)C1",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)CC(CO)(CO)CC(C)C.CI>>COCC(CO)(CC(C)C)CC(C)C",
        "output": "140"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNCC1.CCO.Cc1cc(C)c(C=O)[nH]1.O=C1Cc2c(cccc2-c2cccc(Cl)c2)N1>>Cc1cc(C)c(C=C2C(=O)Nc3cccc(-c4cccc(Cl)c4)c32)[nH]1",
        "output": "440"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.CI.O=C([O-])[O-].Oc1c(Br)cc(F)cc1Br.[K+].[K+]>>COc1c(Br)cc(F)cc1Br",
        "output": "62"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1cc(-c2nn([C@@H]3CC[C@@H](N4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1N.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cc2ccccc2o1.c1ccncc1>>COc1cc(-c2nn([C@@H]3CC[C@@H](N4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1NC(=O)c1cc2ccccc2o1",
        "output": "860"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.O=c1[nH]cnc2cc(F)ccc12.OCc1ccccc1.[H-].[Na+]>>O=c1[nH]cnc2cc(OCc3ccccc3)ccc12",
        "output": "636"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)c1c2c(nn1C)-c1nc(Nc3ccc(Br)cc3OC)ncc1CCC2.[Na+].[OH-]>>COc1cc(Br)ccc1Nc1ncc2c(n1)-c1nn(C)c(C(=O)O)c1CCC2",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.Clc1cc(Cl)nc(Cl)n1.NC1CCCCC1>>Clc1cc(Cl)nc(NC2CCCCC2)n1",
        "output": "544"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCNCC2)c1.O=C(CCCCl)c1ccc(F)cc1.O=C([O-])[O-].[K+].[K+]>>CC(C)C(=O)Nc1cccc(C2CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1",
        "output": "138"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1ccc2c(c1)CCO2.CO.[NH4+].[Ni].[OH-]>>CC(N)c1ccc2c(c1)CCO2",
        "output": "552"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1ccc(Oc2ccc(CC(NC(=O)OC(C)(C)C)C(=O)N(C)C)cc2)nc1.O.[Li+].[OH-]>>CN(C)C(=O)C(Cc1ccc(Oc2ccc(C(=O)O)cn2)cc1)NC(=O)OC(C)(C)C",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCBr.O[C@@]12CCC[C@@H]3Oc4c(OCc5ccccc5)ccc5c4[C@@]31CCN(CC1CC1)[C@@H]2C5.[H-].[Na+]>>C=CCO[C@@]12CCC[C@@H]3Oc4c(OCc5ccccc5)ccc5c4[C@@]31CCN(CC1CC1)[C@@H]2C5",
        "output": "120"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1CCCC(CCl)C1.Cc1cc(C)cc(-c2c(O)c3ccc(Cl)cc3[nH]c2=O)c1.Cl.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>Cc1cc(C)cc(-c2c(OCC3CCCN(C)C3)c3ccc(Cl)cc3[nH]c2=O)c1",
        "output": "74"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCO[C@](CCO)(c2ccc(Cl)c(Cl)c2)C1>>CS(=O)(=O)OCC[C@@]1(c2ccc(Cl)c(Cl)c2)CN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCO1",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCCC(O)c1ccc(-c2ccc(Cl)cc2)cc1.CCCCP(CCCC)CCCC.CCOC(=O)COc1ccc(O)cc1C.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CCCCC(Oc1ccc(OCC(=O)OCC)c(C)c1)c1ccc(-c2ccc(Cl)cc2)cc1",
        "output": "342"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1c([C@@H](O)CN2CCNCC2)ccc2c1COC2=O.Cc1nc(C2CO2)ccc1C#N>>Cc1nc(C(O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)ccc1C#N",
        "output": "76"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCc1cccc(C)c1CNc1cc(C(=O)O)cn2c(C)nnc12.CN(C)C=O.CNC.O=C(n1ccnc1)n1ccnc1>>CCc1cccc(C)c1CNc1cc(C(=O)N(C)C)cn2c(C)nnc12",
        "output": "256"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(C)=O.CN(CCC1CCN(c2ccc(O)cc2)CC1)c1ccc(OC(F)(F)F)cc1.Cc1ccc(S(=O)(=O)OC[C@H](O)CCn2cc([N+](=O)[O-])nc2Cl)cc1.O=P([O-])([O-])[O-].[I-].[K+].[K+].[K+].[Na+]>>CN(CCC1CCN(c2ccc(OC[C@H](O)CCn3cc([N+](=O)[O-])nc3Cl)cc2)CC1)c1ccc(OC(F)(F)F)cc1",
        "output": "438"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CO.NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1NCC21CCN(Cc2ccccc2)CC1.[OH-].[OH-].[Pd+2]>>NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1NCC21CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCC/C=C\\C/C=C\\CCCCCCCCBr.COC(=O)CN(CC(=O)OC)c1cccc(O)c1>>CCCCC/C=C\\C/C=C\\CCCCCCCCOc1cccc(N(CC(=O)OC)CC(=O)OC)c1",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.N#CCCn1cnc2ccccc21.O.[Cl-].[H][H].[Na+].[Na+].[Ni].[OH-]>>NCCCn1cnc2ccccc21",
        "output": "246"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCC(=O)Nc1n[nH]c2cc(-c3ccc(OCc4ccccc4)cc3)c(-c3cccnc3)cc12.C[Si](C)(C)I>>CCCC(=O)Nc1n[nH]c2cc(-c3ccc(O)cc3)c(-c3cccnc3)cc12",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc2c(O)nc(OC)nc2c1.O=P(Cl)(Cl)Cl>>COc1ccc2c(Cl)nc(OC)nc2c1",
        "output": "25"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)[C@H](C(C)C)N1Cc2cc(-c3ccc(N)cc3)ccc2C1=O.COC(=O)[C@H](C(C)C)N1Cc2cc(-c3ccc(NC(=S)Nc4ccccc4F)cc3)ccc2C1=O.N#Cc1ccc(N=C=S)cc1>>COC(=O)[C@H](C(C)C)N1Cc2cc(-c3ccc(NC(=S)Nc4ccc(C#N)cc4)cc3)ccc2C1=O",
        "output": "474"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Nc1ccc2cccc(O)c2n1.O=C(/N=N/C(=O)OCc1ccccc1)OCc1ccccc1.OCCCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Nc1ccc2cccc(OCCCO)c2n1",
        "output": "547"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCP(CCCC)CCCC.CCOCC.Cc1cc(Cl)c(O)c(Cl)c1.Cc1ccccc1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.OCCc1ccc(Br)cc1>>Cc1cc(Cl)c(OCCc2ccc(Br)cc2)c(Cl)c1",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCC/C=C\\C/C=C\\CCCCCCCCN(CCCCCCCC/C=C\\C/C=C\\CCCCC)C(=O)CCCCNC(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CCCCC/C=C\\C/C=C\\CCCCCCCCN(CCCCCCCC/C=C\\C/C=C\\CCCCC)C(=O)CCCCN",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(N)CO.Clc1cccc(Cl)n1.[H-].[Na+]>>CC(N)COc1cccc(Cl)n1",
        "output": "433"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)CCC(C)(C)c2cc(C3=C(CO)CCCC3)ccc21.ClCCl.[Mn+4].[O-2].[O-2]>>CC1(C)CCC(C)(C)c2cc(C3=C(C=O)CCCC3)ccc21",
        "output": "183"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCCc1cc(CO[Si](C)(C)C(C)(C)C)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2.OCCOCC1CCCO1.[F-]>>CCCc1cc(CO)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2",
        "output": "708"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)n1nc(-c2ccc(F)cc2)c2cc(C(=O)O)ccc21.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(=O)n1nc(-c2ccc(F)cc2)c2cc(C(=O)Cl)ccc21",
        "output": "448"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(C(=O)O)c(F)c1.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.COc1ccc([C@@H](O)Cc2c(Cl)c[n+]([O-])cc2Cl)cc1OC.ClCCl>>COc1ccc([C@H](Cc2c(Cl)c[n+]([O-])cc2Cl)OC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2F)cc1OC",
        "output": "33"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COC(=O)COc1cccnc1Cl.NN.O>>NNC(=O)COc1cccnc1Cl",
        "output": "130"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOCC.CN(C)C=O.COc1cccc(CO)c1.Clc1cccc(Cl)n1.O.[H-].[Na+]>>COc1cccc(COc2cccc(Cl)n2)c1",
        "output": "433"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)CCCC(C)(C)N1[O].CN(C)C=O.Cc1cc(OCc2ccccc2)c(C)cc1CO>>Cc1cc(OCc2ccccc2)c(C)cc1C=O",
        "output": "179"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccc(I)cc1.CCOC(=O)c1cnn(-c2cccc(-c3ccccc3O)n2)c1C(F)(F)F.CN(C)C=O.O=C([O-])[O-].[Cl-].[Cs+].[Cs+].[NH4+]>>CCOC(=O)c1cnn(-c2cccc(-c3ccccc3OCc3ccc(I)cc3)n2)c1C(F)(F)F",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.COCc1ccc(C(=O)O)c(N)n1.F[P-](F)(F)(F)(F)F.NCc1cccc(Oc2cccc(OC(F)(F)F)c2)c1.O>>COCc1ccc(C(=O)NCc2cccc(Oc3cccc(OC(F)(F)F)c3)c2)c(N)n1",
        "output": "790"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=[N+]=[N-].CCOCC.O=C(O)[C@H]1Cc2c(n(C(=S)SCc3cccs3)c3ccccc23)CN1C(=S)SCc1cccs1>>COC(=O)[C@H]1Cc2c(n(C(=S)SCc3cccs3)c3ccccc23)CN1C(=S)SCc1cccs1",
        "output": "60"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)/N=N/C(=O)OCC.OCCCBr.Oc1cccc(Br)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>BrCCCOc1cccc(Br)c1",
        "output": "478"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CCN(CC)CC.COc1cc2c(cc1OC)C(=O)N(CC1CCCN(CCc3ccc(N)cc3)C1)C2.ClCCl>>COc1cc2c(cc1OC)C(=O)N(CC1CCCN(CCc3ccc(NC(C)=O)cc3)C1)C2",
        "output": "9"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC(N)C1.CCC(=O)Cl.CCN(CC)CC.ClCCl.O>>CCC(=O)NC1CN(C(=O)OC(C)(C)C)C1",
        "output": "45"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C1CC(c2ccnnc2)=Nc2ccc(Br)cc2N1.OB(O)c1ccccc1F>>O=C1CC(c2ccnnc2)=Nc2ccc(-c3ccccc3F)cc2N1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(F)cc1NC(=O)CC(=O)c1cccc(-c2cccnc2)c1.ClCCl.O=C(O)C(F)(F)F>>O=C1CC(c2cccc(-c3cccnc3)c2)=Nc2ccc(F)cc2N1",
        "output": "930"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CN(C)C=O.COc1ccc(C2CNC(=O)C2)cc1OCc1ccccc1.O=P([O-])([O-])[O-].O=[N+]([O-])c1cccc(I)c1.[Cu]I.[K+].[K+].[K+]>>COc1ccc(C2CC(=O)N(c3cccc([N+](=O)[O-])c3)C2)cc1OCc1ccccc1",
        "output": "921"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.ClCCl.O.O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCC(CO)C1>>O=CC1CCCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1",
        "output": "142"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCCCCC(N)C(=O)O.CS(C)=O>>CCCCCCC(NC(=O)OC(C)(C)C)C(=O)O",
        "output": "626"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C=O.CNCCc1ccccn1.O.O=C(Nc1ccc(F)c([N+](=O)[O-])c1)c1ccccc1-c1ccc(C(F)(F)F)cc1>>CN(CCc1ccccn1)c1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.Cc1c(C(=O)O)nn(C)c1-c1ccccc1-c1cc2ccccc2o1.ClCCl.OCCN1CCCNCC1>>Cc1c(C(=O)N2CCCN(CCO)CC2)nn(C)c1-c1ccccc1-c1cc2ccccc2o1",
        "output": "663"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cccc2c1OCC2>>O=C(Cl)c1cccc2c1OCC2",
        "output": "448"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CCN(CC)CC.CCOC(=O)c1cc2cc(N)ccc2n1C(=O)OC(C)(C)C.ClCCl.O>>CCOC(=O)c1cc2cc(NC(C)=O)ccc2n1C(=O)OC(C)(C)C",
        "output": "9"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(=O)[O-].CN(C)C(=O)C1(N2CCNCC2)CCCCC1.CN(C[C@@H](CC=O)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1.Cl.[Na+].[Na+]>>CN(C)C(=O)C1(N2CCN(CC[C@H](CN(C)C(=O)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)CCCCC1",
        "output": "484"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)N(C)C.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cn1nc(NS(C)(=O)=O)c2c(Cl)ccc(-c3ccc(Cl)nc3[C@@H](N)Cc3cc(F)cc(F)c3)c21.F[P-](F)(F)(F)(F)F.O=C(O)Cn1nc(C(F)F)c2c1C(F)(F)[C@@H]1C[C@H]21>>Cn1nc(NS(C)(=O)=O)c2c(Cl)ccc(-c3ccc(Cl)nc3[C@H](Cc3cc(F)cc(F)c3)NC(=O)Cn3nc(C(F)F)c4c3C(F)(F)[C@@H]3C[C@H]43)c21",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CI.Cc1ccc(S(=O)(=O)N2C(CCc3ncc[nH]3)CCC2c2ccc(F)cc2)cc1.[H-].[Na+]>>Cc1ccc(S(=O)(=O)N2C(CCc3nccn3C)CCC2c2ccc(F)cc2)cc1",
        "output": "404"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCOC(=O)N1C[C@H](OS(C)(=O)=O)C[C@H]1CCn1ccnc1CO[Si](C)(C)C(C)(C)C.CO.Cl>>C=CCOC(=O)N1C[C@H](OS(C)(=O)=O)C[C@H]1CCn1ccnc1CO",
        "output": "708"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.ClCCl.Nn1cccc1C(=O)c1ccccc1.O=C(O)CNC(=O)OCc1ccccc1>>O=C(CNC(=O)OCc1ccccc1)Nn1cccc1C(=O)c1ccccc1",
        "output": "459"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COc1ncncc1[N+](=O)[O-].[Ni]>>COc1ncncc1N",
        "output": "660"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(C(=O)O)cc1-c1[nH]ncc1Cl.Cc1nc(C)c(-c2cc(C(=O)O)ccc2C)[nH]1.Cl.Cl.N#Cc1ccc(C2(F)CCNCC2)cc1.N#Cc1ccc(C2CNC2)cc1>>Cc1ccc(C(=O)N2CCC(F)(c3ccc(C#N)cc3)CC2)cc1-c1[nH]ncc1Cl",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CI.Nc1ccc(C(=O)O)s1>>COC(=O)c1ccc(N)s1",
        "output": "415"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)Cc1cccc(C(=O)O)c1.Nc1cccc(-c2ccccc2)c1>>CCOC(=O)Cc1cccc(C(=O)Nc2cccc(-c3ccccc3)c2)c1",
        "output": "50"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCO.CNC.ClCCl.O.O=S(=O)(Cl)c1cnc(Cl)c(Br)c1.[Cl-].[Na+]>>CN(C)S(=O)(=O)c1cnc(Cl)c(Br)c1",
        "output": "169"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "FC1(CBr)COC1.O=C(c1c[nH]c2cc(Cl)ccc12)N1CCC2(CC1)OCc1ccccc12>>O=C(c1cn(CC2(F)COC2)c2cc(Cl)ccc12)N1CCC2(CC1)OCc1ccccc12",
        "output": "470"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCO.C1CCOC1.CCN(C(C)C)C(C)C.Cc1cc(C)cc(I)c1.ClC(Cl)Cl.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Cl-].[Cu]I.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(C)cc(C#CCO)c1",
        "output": "664"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)Nc1nc(C#N)c(C#N)nc1Cl.CN.O>>CNc1nc(C#N)c(C#N)nc1NC(C)(C)C",
        "output": "148"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)N1CCN(c2ccc(NC(=O)OC(C)(C)C)c([N+](=O)[O-])c2)CC1.ClCCl.O=C(O)C(F)(F)F>>CC(C)N1CCN(c2ccc(N)c([N+](=O)[O-])c2)CC1",
        "output": "782"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C[C@@H]1CN(c2ccc(Nc3ncc4ccn(Cc5ccccc5N(C)S(C)(=O)=O)c4n3)cc2)CCN1C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>C[C@@H]1CN(c2ccc(Nc3ncc4ccn(Cc5ccccc5N(C)S(C)(=O)=O)c4n3)cc2)CCN1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCBr.CN(C)C=O.COC(=O)C12CCC(NCc3ccc4cc(O)ccc4c3)(CC1)CC2.O.O=C([O-])[O-].[Cl-].[K+].[K+].[Na+]>>CCCCCCCOc1ccc2cc(CNC34CCC(C(=O)OC)(CC3)CC4)ccc2c1",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(CCc2ccccc2CCc2ccccc2)cc1O.[Na+].[OH-]>>O=C(O)c1ccc(CCc2ccccc2CCc2ccccc2)cc1O",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1=COCCC1.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.Fc1n[nH]c2ccc(Br)cc12>>Fc1nn(C2CCCCO2)c2ccc(Br)cc12",
        "output": "878"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COC(=O)Cc1c(Cl)nc(C)nc1SC.I[Cu]I.N#Cc1ccccc1Oc1cccc(O)c1.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)Cc1c(Oc2cccc(Oc3ccccc3C#N)c2)nc(C)nc1SC",
        "output": "668"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)O.O=[N+]([O-])c1ccc2c(c1)CCN2Cc1ccc(Cl)s1>>Nc1ccc2c(c1)CCN2Cc1ccc(Cl)s1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.Cc1nc2c([N+](=O)[O-])cc(N3CCOCC3)cc2n1Cc1cccc2ccccc12.O=C([O-])[O-].[Na+].[Na+]>>Cc1nc2c(N)cc(N3CCOCC3)cc2n1Cc1cccc2ccccc12",
        "output": "269"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)(C(N)=O)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(C(F)(F)F)cc1F>>CC(C)(C)OC(=O)N1CCC(NC(=O)c2ccc(C(F)(F)F)cc2F)(C(N)=O)CC1",
        "output": "718"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(S(C)(=O)=O)ncc2c1=O.NCCCn1ccnc1>>CCOC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(NCCCn3ccnc3)ncc2c1=O",
        "output": "629"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NC(CCNC(N)=O)c1ccc(Cl)cc1.O=C(O)C(F)(F)F>>NC(=O)NCCC(N)c1ccc(Cl)cc1",
        "output": "793"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(C)nc1OCCN.O=S(=O)(Cl)c1ccccc1>>COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(C)nc1OCCNS(=O)(=O)c1ccccc1",
        "output": "43"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=CCBr.CC(C)c1c(O)c2cc(F)ccc2[nH]c1=O>>CC(C)=CCOc1c(C(C)C)c(=O)[nH]c2ccc(F)cc12",
        "output": "77"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClC(Cl)Cl.Nc1cccc(OCCCN2CCOCC2)c1.O.O=C(O)Cc1ccc(F)cc1.On1nnc2ccccc21>>O=C(Cc1ccc(F)cc1)Nc1cccc(OCCCN2CCOCC2)c1",
        "output": "365"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccc4nc(-c5cc(OC)ccc5-c5ccc(Cl)cc5)ccc4c3)n(CC(=O)OC(C)(C)C)c2c1.COc1ccccc1.O=C(O)C(F)(F)F>>COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccc4nc(-c5cc(OC)ccc5-c5ccc(Cl)cc5)ccc4c3)n(CC(=O)O)c2c1",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCC(=O)O.Nc1ccccc1CC(=O)O>>CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)Nc1ccccc1CC(=O)O",
        "output": "365"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COc1ncc(-c2cnc3c(c2)c(-c2cnn(Cc4cccc(F)c4)c2)cn3S(=O)(=O)c2ccc(C)cc2)cc1NS(C)(=O)=O.O.[Li+].[OH-]>>COc1ncc(-c2cnc3[nH]cc(-c4cnn(Cc5cccc(F)c5)c4)c3c2)cc1NS(C)(=O)=O",
        "output": "949"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(CC)CC.C[n+]1ccccc1Cl.Cl.Cl.N[C@@H]1CN2CCC1CC2.O.O=C(O)c1ccc(C(F)(F)F)cc1.[I-]>>O=C(N[C@@H]1CN2CCC1CC2)c1ccc(C(F)(F)F)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2sc3c(c2c1-c1ccc(Br)cc1)CCCC3.[Na+].[OH-]>>Cc1nc2sc3c(c2c(-c2ccc(Br)cc2)c1[C@H](OC(C)(C)C)C(=O)O)CCCC3",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O=C(Nc1cc(Cl)cc2c1OCCO2)C(F)(F)F.[Na+].[OH-]>>Nc1cc(Cl)cc2c1OCCO2",
        "output": "491"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)C(=O)c1ccc(Cc2ccccc2OCCN2CCC(n3c(CO)nc4ccccc43)CC2)cc1.COCCO[AlH2-]OCCOC.Cc1ccccc1.[Na+]>>CCN(CC)Cc1ccc(Cc2ccccc2OCCN2CCC(n3c(CO)nc4ccccc43)CC2)cc1",
        "output": "215"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "B.C1CCOC1.CO.O=C(CCBr)N(c1ccccc1)c1ccccc1>>BrCCCN(c1ccccc1)c1ccccc1",
        "output": "112"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(CC2NCCc3c2cc(OC)c(OC)c3OC)cc1OC.NCc1ccccc1.O=C(Br)CBr>>COc1ccc(CC2c3cc(OC)c(OC)c(OC)c3CCN2CC(=O)NCc2ccccc2)cc1OC",
        "output": "946"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1ccc(-c2nc(C(N)=O)oc2-c2ccc(OCC#N)cc2)cc1.Cl[Co]Cl.O.O.O.O.O.O.O.[BH4-].[Na+].[Na+].[OH-]>>COc1ccc(-c2nc(C(N)=O)oc2-c2ccc(OCCN)cc2)cc1",
        "output": "246"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br.N.Nc1ccc2c(ccc3ccccc32)c1.O.O>>Nc1ccc2c(ccc3ccccc32)c1Br",
        "output": "784"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)S(=O)(=O)c1ccccc1Nc1nc(Cl)ncc1Cl.COc1cc2c(cc1N)CCN(C(CF)CF)CC2>>COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)N(C)C)n1)CCN(C(CF)CF)CC2",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cnn(Cc2sc(-c3cccc(C(F)(F)F)c3)nc2C)c1.O.[Na+].[OH-]>>Cc1nc(-c2cccc(C(F)(F)F)c2)sc1Cn1cc(C(=O)O)cn1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)O.O=C=Nc1ccccc1>>CC(C)OC(=O)Nc1ccccc1",
        "output": "34"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COc1ccc2c(c1)NC(=O)/C2=C\\c1[nH]c(C)c(C(=O)O)c1C.Cl.NCCNc1ccc(C(=O)Nc2ccccc2N)cn1.O.Oc1cccc2[nH]nnc12.[Cl-].[Na+]>>COc1ccc2c(c1)NC(=O)/C2=C\\c1[nH]c(C)c(C(=O)NCCNc2ccc(C(=O)Nc3ccccc3N)cn2)c1C",
        "output": "674"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)[C@H](NC(=O)c1ccc(-c2ccc(F)c(F)c2)cc1N)[C@H](C)OC(C)(C)C.Cc1cc(C)c(N=C=O)c(C)c1.c1ccncc1>>COC(=O)[C@H](NC(=O)c1ccc(-c2ccc(F)c(F)c2)cc1NC(=O)Nc1c(C)cc(C)cc1C)[C@H](C)OC(C)(C)C",
        "output": "993"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(-c3cncc(CC(=O)OC)c3)c(C)c2)cc1C)CC.CO.[Cl-].[NH4+].[Na+].[OH-]>>CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(-c3cncc(CC(=O)O)c3)c(C)c2)cc1C)CC",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CC12CCC(COc3cccc(Br)c3)(CC1)O2.CN(C)C=O.[K+]>>CC12CCC(COc3cccc(B4OC(C)(C)C(C)(C)O4)c3)(CC1)O2",
        "output": "942"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.CO.NC(=O)Cc1ccccc1CCc1nc(Nc2cnn(C3CCNCC3)c2)ncc1C(F)(F)F>>CN1CCC(n2cc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cn2)CC1",
        "output": "217"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.CCOCC.Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N(C)c3ccccc3CO)cc2)cc1.c1ccncc1>>CC(=O)OCc1ccccc1N(C)C(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(C)cc2)cc1",
        "output": "254"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)[C@@H]1CN(Cc2ccccc2)C[C@@H]1Cc1ccccc1.Cl.[Na+].[OH-]>>O=C(O)[C@@H]1CN(Cc2ccccc2)C[C@@H]1Cc1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1Br.O=C(Cl)c1ccccc1.c1ccncc1>>CC(=O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](OC(=O)c2ccccc2)[C@@H]1Br",
        "output": "51"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=Cc1ccc(N2C(=O)[C@H](CC[C@H](OC(C)=O)c3ccc(F)cc3)[C@H]2c2ccc(CCC(O)(COC(C)=O)COC(C)=O)cc2)cc1.O>>CCc1ccc(N2C(=O)[C@H](CC[C@H](OC(C)=O)c3ccc(F)cc3)[C@H]2c2ccc(CCC(O)(COC(C)=O)COC(C)=O)cc2)cc1",
        "output": "555"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.NC(=O)Cc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>N#CCc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12",
        "output": "172"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCOC(=O)CN1CC(O)CC1=O.N>>NC(=O)CN1CC(O)CC1=O",
        "output": "163"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)Cn1c2c(c(-c3cc(Cl)ccc3Br)cc1=O)C(=O)CC2.O=C(O)C(F)(F)F>>O=C(O)Cn1c2c(c(-c3cc(Cl)ccc3Br)cc1=O)C(=O)CC2",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Cl[Pd]Cl.N#Cc1ccccc1B(O)O.O=C(NCCCC(=O)N1CCC[C@@H]1CNC(=O)c1ccc(Cl)nc1NCCC1CCCCO1)OCc1ccccc1.O=C([O-])[O-].[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>N#Cc1ccccc1-c1ccc(C(=O)NC[C@H]2CCCN2C(=O)CCCNC(=O)OCc2ccccc2)c(NCCC2CCCCO2)n1",
        "output": "865"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1O[C@H]1CCNC[C@H]1F.O=C(O)c1cn[nH]c1Cl>>N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1O[C@H]1CCN(C(=O)c2cn[nH]c2Cl)C[C@H]1F",
        "output": "733"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccccc1OC.O=C(O)c1ccncc1>>COc1cccc(C(=O)c2ccncc2)c1OC",
        "output": "275"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.ClCCl.Fc1cc(Br)c2cc[nH]c2c1.O=S(=O)(Cl)c1ccccc1.O=S(=O)([O-])O.[Na+].[OH-]>>O=S(=O)(c1ccccc1)n1ccc2c(Br)cc(F)cc21",
        "output": "648"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)c1sc(-n2ncc3c2CCC(N)C3)nc1C.CCc1[nH]c(C(=O)O)nc1Cl.CN1CCOCC1.Cl.On1nnc2ccccc21>>CCOC(=O)c1sc(-n2ncc3c2CCC(NC(=O)c2nc(Cl)c(CC)[nH]2)C3)nc1C",
        "output": "951"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)COc1ncc(C(=O)NCc2ccccc2)cc1C(=O)NCc1ccccc1.CCOC(C)=O.ClC(Cl)Cl.O=C(O)C(F)(F)F>>O=C(O)COc1ncc(C(=O)NCc2ccccc2)cc1C(=O)NCc1ccccc1",
        "output": "278"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.O=C(O)c1cc(Sc2nc3cc(Cl)ccc3[nH]2)c2[nH]c(=O)[nH]c2c1.O=S(=O)(O)O>>CCOC(=O)c1cc(Sc2nc3cc(Cl)ccc3[nH]2)c2[nH]c(=O)[nH]c2c1",
        "output": "33"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.O=C(c1ccc(O[C@@H]2CCCC[C@H]2N2CCOC2=O)cc1)c1c(-c2ccc(OCCN3CCCC3)cc2)sc2cc(OCc3ccccc3)ccc12.[Pd]>>O=C(c1ccc(O[C@@H]2CCCC[C@H]2N2CCOC2=O)cc1)c1c(-c2ccc(OCCN3CCCC3)cc2)sc2cc(O)ccc12",
        "output": "23"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NC1(C(=O)Nc2ccc(Oc3cccc4c3C(C)(C)CO4)nc2)CC1.CC(C)(C)OC(=O)NC1(C(=O)Nc2ccc(Oc3cccc4c3C(C)(C)CO4)nc2)CCC1>>CC1(C)COc2cccc(Oc3ccc(NC(=O)C4(N)CC4)cn3)c21",
        "output": "431"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccc(Br)cc1.Cc1c[nH]c(=O)n(C(=O)c2ccccc2)c1=O>>Cc1cn(Cc2ccc(Br)cc2)c(=O)n(C(=O)c2ccccc2)c1=O",
        "output": "389"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)NCCCCCCNC(=O)OC(C)(C)C)cc(C)c1O.Cl>>Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)NCCCCCCN)cc(C)c1O",
        "output": "538"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COC(=O)c1cc(C(F)(F)F)cc([N+](=O)[O-])c1C.O.[Cl-].[Fe].[NH4+]>>COC(=O)c1cc(C(F)(F)F)cc(N)c1C",
        "output": "481"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.ClC(Cl)(Cl)Cl.O=C(O)CCCCCCCBr.OCc1ccccc1.c1cc(N2CCCC2)ccn1>>O=C(CCCCCCCBr)OCc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.O.O=C(O)CNC(=O)c1cc(-c2ccccc2)[nH]n1.O=Cc1ccccc1OC1CCNCC1.On1nnc2ccccc21>>O=Cc1ccccc1OC1CCN(C(=O)CNC(=O)c2cc(-c3ccccc3)[nH]n2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCN(C(C)C)C(C)C.O=P(Cl)(Cl)Cl.O=c1[nH]cnc2cc(F)cc(F)c12>>Fc1cc(F)c2c(Cl)ncnc2c1",
        "output": "14"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C1CNCCNC1.CCN(CC)CC.ClCc1ccc(OCc2ccccc2)cc1.O=C([O-])O.[Na+]>>c1ccc(COc2ccc(CN3CCCNCC3)cc2)cc1",
        "output": "156"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCOC(=O)c1coc([C@H](CCCC2CCCCC2)CC(=O)NOCc2ccccc2)n1.O.O.[Li+].[OH-]>>O=C(C[C@@H](CCCC1CCCCC1)c1nc(C(=O)O)co1)NOCc1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(C)=O.Cc1cc(C)n(-c2cncc(Cl)n2)n1.Nc1ccc(Cl)cc1.O.[H-].[Na+]>>Cc1cc(C)n(-c2cncc(Nc3ccc(Cl)cc3)n2)n1",
        "output": "780"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COc1ccc(CCNC(=O)C(O)c2cccc(Cl)c2)cc1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>COc1ccc(CCNCC(O)c2cccc(Cl)c2)cc1",
        "output": "112"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCl.N[C@@H](CO)c1ccccc1.O=C(Cl)c1cccc(Br)c1>>O=C(N[C@@H](CO)c1ccccc1)c1cccc(Br)c1",
        "output": "411"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CN1CCN(CCCN)CC1.COC(=O)c1ccc2cc(-c3nc(Cl)ncc3C)sc2c1>>COC(=O)c1ccc2cc(-c3nc(NCCCN4CCN(C)CC4)ncc3C)sc2c1",
        "output": "544"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)(C)c1ccc(OCC2CO2)cc1.O=C1C(=O)c2ccccc2C2=C1SCC1(CCNCC1)O2.[Li+].[O-][Cl+3]([O-])([O-])[O-]>>CC(C)(C)c1ccc(OCC(O)CN2CCC3(CC2)CSC2=C(O3)c3ccccc3C(=O)C2=O)cc1",
        "output": "76"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1c(-c2ccc(C(C)(C)C)cc2)c2cc(N)ccc2n1Cc1cccc(OC)c1.CCOC(C)=O.Cc1ccccc1.O=CC1CC1.[BH4-].[Na+]>>CCOC(=O)c1c(-c2ccc(C(C)(C)C)cc2)c2cc(NCC3CC3)ccc2n1Cc1cccc(OC)c1",
        "output": "336"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.CC(=O)c1cc(O)ccc1O.CC(C)=O.O.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1cc(OCc2ccccc2)ccc1O",
        "output": "127"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1cc(C)n(CC(=O)N2CCN(c3ccccc3C(=O)O)CC2)n1.ClCCl.Nc1ccncc1.O=C(Cl)C(=O)Cl>>Cc1cc(C)n(CC(=O)N2CCN(c3ccccc3C(=O)Nc3ccncc3)CC2)n1",
        "output": "50"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCOCCCCCCCCCCN.Cc1ccc(OCCCCCCCCN=[N+]=[N-])cc1>>Cc1ccc(OCCCCCCCCN)cc1",
        "output": "89"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(N)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1Cl.ClCCl.O.O=C(Cl)OCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(NC(=O)OCc2ccccc2)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1Cl",
        "output": "509"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)C1CC(NCc2ccc(C)c(F)c2)CCN1CCn1c(=O)cnc2ccc(OC)cc21.ClC(Cl)Cl.ClCCl.O>>COC(=O)C1CC(N(Cc2ccc(C)c(F)c2)C(=O)OC(C)(C)C)CCN1CCn1c(=O)cnc2ccc(OC)cc21",
        "output": "867"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cl.O=C(Nc1ccccc1-c1ccccc1)OC1CCN(Cc2ccccc2)CC1.O=C[O-].OC1CCN(Cc2ccccc2)CC1.[NH4+]>>O=C(Nc1ccccc1-c1ccccc1)OC1CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CCNC3)cc1.CN(C)C=O.Clc1cc(C2CC2)ncn1>>CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CCN(c2cc(C4CC4)ncn2)C3)cc1",
        "output": "162"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.Cc1nc2ccc(NC(=O)OCC(Cl)(Cl)Cl)cc2o1.O.c1ccc(-c2csc(N3CCNCC3)n2)cc1>>Cc1nc2ccc(NC(=O)N3CCN(c4nc(-c5ccccc5)cs4)CC3)cc2o1",
        "output": "980"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.N#Cc1ccc2[nH]cc(CCCCCCl)c2c1.O=C([O-])[O-].O=c1ccccn1-c1ccc(N2CCNCC2)cc1.[I-].[K+].[K+].[K+]>>N#Cc1ccc2[nH]cc(CCCCCN3CCN(c4ccc(-n5ccccc5=O)cc4)CC3)c2c1",
        "output": "138"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cc(N)ccc1Br.O=[N+]([O-])c1cccc(B(O)O)c1>>Cc1cc(N)ccc1-c1cccc([N+](=O)[O-])c1",
        "output": "837"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1cnccc1Nc1cc(N)nc(-c2nn(Cc3c(C)noc3C)c3ccccc23)n1.Cl.NCCO.O>>Cc1noc(C)c1Cn1nc(-c2nc(N)cc(Nc3ccncc3C(=O)NCCO)n2)c2ccccc21",
        "output": "498"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C(CCCCSc1ccc(O)cc1)N1CCOCC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Oc1ccc(SCCCCCN2CCOCC2)cc1",
        "output": "112"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O=C(CN1CCC(N2Cc3ccccc3NC2=O)CC1)c1cccc(Cl)c1.[BH4-].[Na+]>>O=C1Nc2ccccc2CN1C1CCN(CC(O)c2cccc(Cl)c2)CC1",
        "output": "24"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.Cl.O.OC1(c2ncc(Br)s2)CCC2(CC1)OCCO2>>O=C1CCC(O)(c2ncc(Br)s2)CC1",
        "output": "251"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br.COc1ccc2cc(C(=O)O)c(C)nc2c1.O>>Cc1nc2cc(O)ccc2cc1C(=O)O",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(c2cccc(C)c2)=CCC3(C)C)cc1.Cl.O=C([O-])c1ccccc1.[Na+].[OH-]>>Cc1cccc(C2=CCC(C)(C)c3ccc(C#Cc4ccc(C(=O)O)cc4)cc32)c1",
        "output": "5"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.O=S(Cl)Cl.OCc1ccc(-c2ccc(C(F)(F)F)cn2)cc1>>FC(F)(F)c1ccc(-c2ccc(CCl)cc2)nc1",
        "output": "81"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=C(C)OC(=O)Cl.CCN(CC)CC.CCn1cc(C(=O)O)c(=O)c2ccc(C)nc21.ClCCl.NCCc1ccncc1>>CCn1cc(C(=O)NCCc2ccncc2)c(=O)c2ccc(C)nc21",
        "output": "674"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.CCN(C(C)C)C(C)C.CN1CCCC1=O.Fc1ccc(-n2ncnc2-c2cc3c(s2)-c2nc(-c4ccc(F)nc4)ccc2OCC3)c(F)c1>>Fc1ccc(-n2ncnc2-c2cc3c(s2)-c2nc(-c4ccc(N5CCCC5)nc4)ccc2OCC3)c(F)c1",
        "output": "756"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)[C@H](NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C(=O)O.Cl.OC(c1nc2ccccc2s1)[C@@H]1CCCN1.On1nnc2ccccc21>>CC(C)[C@H](NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(O)c1nc2ccccc2s1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)COc1ccc(Cl)cc1.CO.O.[K+].[OH-]>>O=C(O)COc1ccc(Cl)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](CN)CC1.CS(C)=O.Cl.ClCCl.O=S(=O)(Cl)c1cccc(-c2ccccc2)c1>>CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](CNS(=O)(=O)c2cccc(-c3ccccc3)c2)CC1",
        "output": "43"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COCCl.Cc1nnc(-c2ccc3occ(-c4cn[nH]c4)c3c2)o1.O.[H-].[Na+]>>COCn1cc(-c2coc3ccc(-c4nnc(C)o4)cc23)cn1",
        "output": "910"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(C(=O)O)nc1C.I.O.O=S([O-])[O-].[Na+].[Na+]>>Cc1nc(C(=O)O)ccc1O",
        "output": "424"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1ccccc1CN1C(=O)S/C(=C\\c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)C1=O.NCCO>>O=C(O)c1ccccc1CN1C(=O)S/C(=C\\c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)C1=O",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COC(=O)c1nc([C@@H]2CC[C@@H](C)NC2)sc1C.ClCCl.F[P-](F)(F)(F)(F)F.O.O=C(O)c1ccccc1-c1ncccn1>>COC(=O)c1nc([C@@H]2CC[C@@H](C)N(C(=O)c3ccccc3-c3ncccn3)C2)sc1C",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.CCN(CC)CC.CCOC(C)=O.Cn1nc(C(C)(C)C)cc1NC(=O)Nc1ccc(Cc2ccc(N)cc2)cc1>>CC(=O)Nc1ccc(Cc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3C)cc2)cc1",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OCc1cc(O[C@@H]2CCOC2)cc(C)c1-c1cccc(CO)c1.CC(C)OC(=O)N=NC(=O)OC(C)C.COC(=O)C[C@@H]1COc2cc(O)ccc21.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)C[C@@H]1COc2cc(OCc3cccc(-c4c(C)cc(O[C@@H]5CCOC5)cc4COC(C)=O)c3)ccc21",
        "output": "347"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN1CCNCC1.O=[N+]([O-])c1cnc(Cl)c([N+](=O)[O-])c1>>CCN1CCN(c2ncc([N+](=O)[O-])cc2[N+](=O)[O-])CC1",
        "output": "220"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(CN2CCSc3ncc(OC)cc3C2)cn1.O.[Li+].[OH-]>>COc1cnc2c(c1)CN(Cc1ccc(C(=O)O)nc1)CCS2",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Br.CO.COc1cccc(Cl)c1-c1ccccc1C.O.O=C([O-])[O-].[K+].[K+]>>Cc1ccccc1-c1c(O)cccc1Cl",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)C1(C(=O)OCc2ccccc2)CCCCC1.CCOC(C)=O.[Pd]>>CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)C1(C(=O)O)CCCCC1",
        "output": "186"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNC1.CC1(C)CN(CC2Cc3ccc(Cl)nc3C2)c2nc(-c3ccncc3)cc(=O)n2C1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC1(C)CN(CC2Cc3ccc(N4CCCC4)nc3C2)c2nc(-c3ccncc3)cc(=O)n2C1",
        "output": "220"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.CN1CCc2[nH]c3ccc(C(C)(C)C)cc3c2C1.[H-].[Na+].c1cc(C2CO2)ccn1>>CN1CCc2c(c3cc(C(C)(C)C)ccc3n2CC(O)c2ccncc2)C1",
        "output": "749"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1nccc(Oc2ccc([N+](=O)[O-])cc2F)c1C#Cc1ccccn1.[Cl-].[NH4+].[Zn]>>Nc1ccc(Oc2ccnc(N)c2C#Cc2ccccn2)c(F)c1",
        "output": "335"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(CCI)CC1.Cc1nc2cnc3cc(O)ccc3c2n1CC(C)C>>Cc1nc2cnc3cc(OCCC4CCN(C(=O)OC(C)(C)C)CC4)ccc3c2n1CC(C)C",
        "output": "198"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CCCC(N=[N+]=[N-])c1ccccc1OC.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>C=CCCC(N)c1ccccc1OC",
        "output": "562"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1ccc(C2CNC2)cc1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1ccc(C(=O)O)cc1N.Cl.F[P-](F)(F)(F)(F)F>>COc1ccc(C(=O)N2CC(c3ccc(Br)cc3)C2)cc1N",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.O.[Br-].[Li+].c1ccc2c(c1)OCO2>>Brc1ccc2c(c1)OCO2",
        "output": "784"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.C[Si](C)(C)C=[N+]=[N-].ClCCl.Nc1ccc(CC(=O)O)cc1>>COC(=O)Cc1ccc(N)cc1",
        "output": "195"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCn1ccc2cc(Br)ccc21.OB(O)c1cccc(Cl)c1>>CCCCn1ccc2cc(-c3cccc(Cl)c3)ccc21",
        "output": "837"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCCCC1.CCOC(C)=O.CN1CCOCC1.Cl.ClCCl.NCCC(F)(F)F.O=C(Cl)c1ccc(Cl)nc1>>O=C(NCCC(F)(F)F)c1ccc(Cl)nc1",
        "output": "353"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O=C1Cc2ccc3ccccc3c21.[BH4-].[Na+]>>OC1Cc2ccc3ccccc3c21",
        "output": "24"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "N#Cc1cccc(-c2nnc(C3CCNCC3)o2)c1.O=C(O)C(F)(F)F.O=C(O)CCCc1nc2ccccc2c(=O)[nH]1>>N#Cc1cccc(-c2nnc(C3CCN(C(=O)CCCc4nc5ccccc5c(=O)[nH]4)CC3)o2)c1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CC[O-].Cl.O=C(O)c1cnc(Cl)c(Br)c1.[Na+]>>CCOc1ncc(C(=O)O)cc1Br",
        "output": "433"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)[Si](C)(C)O[C@H]1CNC[C@H](O)C1.CCOC(C)=O.O.O=C(Cl)OCc1ccccc1>>CC(C)(C)[Si](C)(C)O[C@@H]1C[C@@H](O)CN(C(=O)OCc2ccccc2)C1",
        "output": "427"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)C(C)(C)CCOc1ccc2nc(C)n(Cc3ccc(Cl)cc3Cl)c2c1.Cl.[Na+].[OH-]>>Cc1nc2ccc(OCCC(C)(C)C(=O)O)cc2n1Cc1ccc(Cl)cc1Cl",
        "output": "281"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)O.CS(=O)(=O)c1nccc(-c2cc3cn[nH]c3nc2-c2ccco2)n1.Cl.O.[H-].[Na+]>>CC(C)Oc1nccc(-c2cc3cn[nH]c3nc2-c2ccco2)n1",
        "output": "667"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.COc1cc2ncnc(Oc3ccc(N)c(Cl)c3)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCCCOc1ccc(Cl)cc1>>COc1cc2ncnc(Oc3ccc(NC(=O)OCCCOc4ccc(Cl)cc4)c(Cl)c3)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)c1cc(N)ccc1F.CCOC(C)=O.CS(=O)(=O)Cl.c1ccncc1>>CC(=O)c1cc(NS(C)(=O)=O)ccc1F",
        "output": "194"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cc1ccccc1.N#CCCCc1ccccc1[N+](=O)[O-].O.[Cl-].[Fe].[NH4+]>>N#CCCCc1ccccc1N",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CCOC(=O)c1[nH]nnc1Nc1ccc(C)cc1.O.[Na+].[OH-]>>Cc1ccc(Nc2nn[nH]c2C(=O)O)cc1",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN.O.O=C(O)CCc1csc(Nc2ncc(Br)cc2Oc2ccccc2)n1.On1nnc2ccccc21>>CNC(=O)CCc1csc(Nc2ncc(Br)cc2Oc2ccccc2)n1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NCCCCc1ccc(-c2ccc(=O)[nH]n2)cc1.O=C(O)c1ccnnc1>>O=C(NCCCCc1ccc(-c2ccc(=O)[nH]n2)cc1)c1ccnnc1",
        "output": "674"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.Clc1nccc2[nH]ccc12.Fc1ccc(CBr)cc1.O.[H-].[Na+]>>Fc1ccc(Cn2ccc3c(Cl)nccc32)cc1",
        "output": "528"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.CCN(C(C)C)C(C)C.ClCCl.N#Cc1ccc(C(=O)CBr)cc1>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)OCC(=O)c1ccc(C#N)cc1",
        "output": "523"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.O.O=C1Nc2ccc(I)cc2C1=NNC(=O)c1ccc(O[C@@H](Cc2ccccc2)C(=O)OCc2ccccc2)cc1.[Na+].[OH-]>>O=C1Nc2ccc(I)cc2C1=NNC(=O)c1ccc(O[C@@H](Cc2ccccc2)C(=O)O)cc1",
        "output": "186"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NCCO.O.O=C(O)c1cccc(SCc2c(O[C@H](Cn3ccnc3)c3ccccc3)ccc3c2CCCC3=O)c1.O=C(n1ccnc1)n1ccnc1>>O=C(NCCO)c1cccc(SCc2c(O[C@H](Cn3ccnc3)c3ccccc3)ccc3c2CCCC3=O)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)N1CCN(C(=O)OC(C)(C)C)CC1c1ccccc1.ClCCl.O=C(O)C(F)(F)F>>CC(=O)N1CCNCC1c1ccccc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)C=C(c2ccc3ccccc3c2)c2ccc(O)cc2O1.CN(C)CCOc1ccc2c(c1)OC(C)(C)CC2c1ccc(C(F)(F)F)cc1.CN(CCCl)Cc1ccccc1.Cl>>CN(CCOc1ccc2c(c1)OC(C)(C)C=C2c1ccc2ccccc2c1)Cc1ccccc1",
        "output": "74"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(C(=O)NC2CCCCC2)n(-c2ccc(OC3CCN(C(=O)OC(C)(C)C)CC3)cc2)n1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(C(=O)NC2CCCCC2)n(-c2ccc(OC3CCNCC3)cc2)n1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNCC1.CC(C)c1ccc(S(=O)(=O)Cl)cc1.ClC(Cl)Cl.N.NCC(=O)NCC1CCN(Cc2ccc(Cl)cc2)CC1.O=S(=O)(Cl)Cl>>CC(C)c1ccc(S(=O)(=O)NCC(=O)NCC2CCN(Cc3ccc(Cl)cc3)CC2)cc1",
        "output": "596"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC#N.NCc1cn(-c2ccc(N3CCSCC3)c(F)c2)nn1.O.O=C(O)c1cnccn1>>O=C(NCc1cn(-c2ccc(N3CCSCC3)c(F)c2)nn1)c1cnccn1",
        "output": "697"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1cn(-c2cc3ccccc3cn2)c2ccccc12.Cl.O.O.[Li+].[OH-]>>O=C(O)c1cn(-c2cc3ccccc3cn2)c2ccccc12",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1cc(N)c2c(c1)C[C@@H](C)O2.O=C1CCC(=O)N1Br>>Cc1cc(N)c2c(c1Br)C[C@@H](C)O2",
        "output": "4"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCNc1nc(N)nc(C)c1Cc1ccc(C#CCN(C)C)cc1.CCO.[Pt]>>CCCCCNc1nc(N)nc(C)c1Cc1ccc(CCCN(C)C)cc1",
        "output": "717"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1cc2c(C(F)(F)F)c(C#N)ccc2n1C(C)CO.ClCCl>>Cc1cc2c(C(F)(F)F)c(C#N)ccc2n1C(C)COS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.O=C(OCc1ccccc1)N1CCN(c2ccc(OC3CCNCC3)cc2)C(=O)C1.O=C1CCCC1.[Na+]>>O=C(OCc1ccccc1)N1CCN(c2ccc(OC3CCN(C4CCCC4)CC3)cc2)C(=O)C1",
        "output": "187"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc(N(c2ccccc2)c2ccccc2)cc1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CS(C)=O.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc(N(c3ccccc3)c3ccccc3)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Cn1c(=O)c2c(nc(CC(=O)O)n2Cc2cccc(Br)c2)n(C)c1=O.NCCO.O=C(n1ccnc1)n1ccnc1>>Cn1c(=O)c2c(nc(CC(=O)NCCO)n2Cc2cccc(Br)c2)n(C)c1=O",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(NC(=O)OC(C)(C)C)c1ccc(CCN)cc1.CN1CCCC1=O.CS(=O)(=O)c1nccc(N2CCC(=O)N3CC=C(c4ccccc4)N=C32)n1>>CC(NC(=O)OC(C)(C)C)c1ccc(CCNc2nccc(N3CCC(=O)N4CC=C(c5ccccc5)N=C43)n2)cc1",
        "output": "629"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.COC(=O)Cc1cccc(O)c1.Cc1oc(-c2ccccc2)nc1CCl.O=C([O-])[O-].[K+].[K+]>>COC(=O)Cc1cccc(OCc2nc(-c3ccccc3)oc2C)c1",
        "output": "760"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCCCCC(CCCCCCC)c1c(C(=O)OCC)sc2c(Br)csc12.CCO.O.[Na+].[OH-]>>CCCCCCCCCC(CCCCCCC)c1c(C(=O)O)sc2c(Br)csc12",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CNCCNC1.O=C(O)c1cc(Cl)ccc1[N+](=O)[O-].O=S(=O)([O-])O.[K+]>>O=C(O)c1cc(N2CCCNCC2)ccc1[N+](=O)[O-]",
        "output": "105"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCP(=CC#N)(CCCC)CCCC.COCC(O)CN1CCOc2cc3c(c(C4CC4)c21)CCN(C(=O)OC(C)(C)C)CC3.Cc1ccccc1.Oc1ccccc1F>>COCC(CN1CCOc2cc3c(c(C4CC4)c21)CCN(C(=O)OC(C)(C)C)CC3)Oc1ccccc1F",
        "output": "846"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CS(=O)(=O)Cl.ClCCl.O=C([O-])[O-].[Na+].[Na+].c1ccc(CN2CCNCC2)cc1>>CS(=O)(=O)N1CCN(Cc2ccccc2)CC1",
        "output": "584"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N(C)C.Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncc2nc(N)sc2n1.O.O=C(Cl)CCl>>Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncc2nc(NC(=O)CCl)sc2n1",
        "output": "553"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.CSc1ncc2c(n1)N(C(C)C)C(=O)N(c1cc(C#N)cc([N+](=O)[O-])c1)C2.Cl.[Fe]>>CSc1ncc2c(n1)N(C(C)C)C(=O)N(c1cc(N)cc(C#N)c1)C2",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClCc1ccc2oc(-c3cccs3)nc2c1.Oc1cccc(CCCCn2ccnc2)c1>>c1cc(CCCCn2ccnc2)cc(OCc2ccc3oc(-c4cccs4)nc3c2)c1",
        "output": "49"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N1CCC(=O)CC1.CC(C)[O-].CCO.O.O=C1NC(Cc2ccccc2)C(=O)N1C1CCNCC1.[BH3-]C#N.[Na+].[Ti+4]>>CC(C)(C)OC(=O)N1CCC(N2CCC(N3C(=O)NC(Cc4ccccc4)C3=O)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N(Cc1cc(CCCO)cc2cccnc12)C1CC1.CI.[H-].[Na+]>>COCCCc1cc(CN(C(=O)OC(C)(C)C)C2CC2)c2ncccc2c1",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)CCC(=O)Nc1ccc(C(=O)NN=C2C(=O)Nc3ccc(I)cc32)cc1.O.[Na+].[OH-]>>O=C(O)CCC(=O)Nc1ccc(C(=O)NN=C2C(=O)Nc3ccc(I)cc32)cc1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.O=C([O-])O.Oc1cccc(N2CCNCC2)c1.[Na+].[Na+]>>CC(C)N1CCN(c2cccc(O)c2)CC1",
        "output": "187"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(=O)c1cc(C=O)c2ccccn2c1=O.Cc1ccnc(C2(C#N)CCNCC2)c1.[Na+]>>CCOC(=O)c1cc(CN2CCC(C#N)(c3cc(C)ccn3)CC2)c2ccccn2c1=O",
        "output": "757"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCP(CCCC)CCCC.CCOC(=O)C(C)(C)Oc1ccc(O)c(C)c1C.CN(C)C(=O)N=NC(=O)N(C)C.OCC(C1CCCCC1)n1c(-c2ccc(Cl)cc2)nc2cc(F)c(F)cc21>>CCOC(=O)C(C)(C)Oc1ccc(OCC(C2CCCCC2)n2c(-c3ccc(Cl)cc3)nc3cc(F)c(F)cc32)c(C)c1C",
        "output": "478"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.Nc1cccnc1Br.O=S(=O)(Cl)c1ccc(F)cc1.c1ccncc1>>O=S(=O)(Nc1cccnc1Br)c1ccc(F)cc1",
        "output": "554"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.N#Cc1ccc(N2CCc3c(ncnc3Nc3ccc([N+](=O)[O-])cn3)C2)cc1C(F)(F)F.[Pd]>>N#Cc1ccc(N2CCc3c(ncnc3Nc3ccc(N)cn3)C2)cc1C(F)(F)F",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(F)(F)c1cccc([N+](=O)[O-])c1.CCOC(C)=O.[Zn]>>CC(F)(F)c1cccc(N)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#Cc1ccc(-c2ccc(Cl)cc2)cn1.Ic1ccc(NC[C@@H]2CCCN2)cc1>>Clc1ccc(-c2ccc(C#Cc3ccc(NC[C@@H]4CCCN4)cc3)nc2)cc1",
        "output": "664"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O.[K+].[Na+].[OH-].[OH-]>>O=C(O)CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)CCC(=O)N(C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)c1cc(C)n(-c2ccccc2)c1-c1ccccc1)C(C)C.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li+].[OH-]>>Cc1cc(C(=O)N2CCN(C(=O)OC(C)(C)C)C[C@H]2CN(C(=O)CCC(=O)O)C(C)C)c(-c2ccccc2)n1-c1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Br.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1B1OC(C)(C)C(C)(C)O1",
        "output": "943"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCCCCCCBr.C#CCCCCO.O.[Na+].[OH-]>>C#CCCCCOCCCCCCBr",
        "output": "95"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCN(CC)CC.N#Cc1c(C(N)=O)c2n(c1C1CC1)CCNC2.O=C(O)C(F)(F)F.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1>>N#Cc1c(C(N)=O)c2n(c1C1CC1)CCN(S(=O)(=O)c1ccc(C(F)(F)F)cc1)C2",
        "output": "99"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COC(=O)Cc1c2c(=O)n(C)c(=O)n(C)c2nn1C.O.O=S(=O)(O)O>>Cn1nc2c(c1CC(=O)O)c(=O)n(C)c(=O)n2C",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)n1cc(-c2ccnc(N)c2)c(-c2ccc(F)cc2)n1.CCN(CC)CC.O=C(Cl)C1CC1>>CC(C)n1cc(-c2ccnc(NC(=O)C3CC3)c2)c(-c2ccc(F)cc2)n1",
        "output": "332"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)CC1.CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCC(OS(C)(=O)=O)CC1",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)C(C)(C)Oc1ccc(CCCC(=O)O)cc1.Cc1nc(-c2ccc(C(F)(F)F)cc2)ccc1N>>Cc1nc(-c2ccc(C(F)(F)F)cc2)ccc1NC(=O)CCCc1ccc(OC(C)(C)C(=O)OC(C)(C)C)cc1",
        "output": "724"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CO.Cc1ccc(N)cc1-c1ccc2c(c1)[nH]c1ncncc12.O=C=Nc1cccc(C(F)(F)F)c1>>Cc1ccc(NC(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2c(c1)[nH]c1ncncc12",
        "output": "473"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCn2c(nc(C(=O)NCc3ccc(F)cc3)c(O)c2=O)C1CO.CCN(CC)CC.CS(=O)(=O)Cl.ClC(Cl)Cl>>CC(C)(C)OC(=O)N1CCn2c(nc(C(=O)NCc3ccc(F)cc3)c(O)c2=O)C1COS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.Nc1cc2c(cc1CO)c(Br)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1.O=[Mn]=O>>Nc1cc2c(cc1C=O)c(Br)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "179"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)NCCN1CCc2cc([N+](=O)[O-])ccc2C1.CCOC(C)=O.[H][H].[Pd]>>CC(=O)NCCN1CCc2cc(N)ccc2C1",
        "output": "507"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COC(=O)c1cc(OCc2c(-c3ccc(F)cc3)noc2CO)nn1C.Cl.O.[Li+].[OH-]>>Cn1nc(OCc2c(-c3ccc(F)cc3)noc2CO)cc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COc1c(Br)cccc1C#N.O=C([O-])[O-].OB(O)c1ccncc1.[Na+].[Na+]>>COc1c(C#N)cccc1-c1ccncc1",
        "output": "904"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CO.Cc1nc(N(C)c2ccc(N)cc2)c2ccccc2n1.Cl.O.O=N[O-].[N-]=[N+]=[N-].[Na+].[Na+]>>Cc1nc(N(C)c2ccc(N=[N+]=[N-])cc2)c2ccccc2n1",
        "output": "189"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC/C=C\\c1c(C)cccc1C(=O)NC1(C(=O)OCC)Cc2ccccc2C1.CCO.O.[K+].[OH-]>>CCC/C=C\\c1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.O.O=[N+]([O-])c1ccc(CN2CCOCC2)cc1.[Cl-].[Fe].[NH4+]>>Nc1ccc(CN2CCOCC2)cc1",
        "output": "507"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NCCO.CCN(CC)CC.CN(C)C.Cc1cc(C)c(S(=O)(=O)Cl)c(C)c1.Cl.ClCCl.O>>Cc1cc(C)c(S(=O)(=O)OCCNC(=O)OC(C)(C)C)c(C)c1",
        "output": "197"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CN(C)C=O.COc1cc2ncc(Cl)nc2cc1OC.O=C(O)[C@@H]1CC[C@@H](O)CC1.[H-].[Na+]>>COc1cc2ncc(O[C@@H]3CC[C@@H](C(=O)O)CC3)nc2cc1OC",
        "output": "209"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "NC(=O)C1=CN([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)C=CC1.OCCCCCCCBr.Oc1ccccc1>>OCCCCCCCOc1ccccc1",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C1CCOC1.CC(=O)c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1.CI.O.[H-].[Na+]>>COc1c(C(C)(C)C)cc(C(C)=O)cc1C(C)(C)C",
        "output": "62"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)c1ccc2cc(-c3ccc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)c(C)c3)ccc2n1.CO.Cl.O.[Na+].[OH-]>>Cc1cc(-c2ccc3nc(C(=O)O)ccc3c2)ccc1OCc1c(-c2c(Cl)cccc2Cl)noc1C(C)C",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.Nc1ccc(OCCCl)c2ccccc12.O=C(O)c1cc(F)cc(N2CCCCC2)c1>>O=C(Nc1ccc(OCCCl)c2ccccc12)c1cc(F)cc(N2CCCCC2)c1",
        "output": "817"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCOC(=O)c1cnc2c(cnn2CC)c1O.O.[Na+].[OH-]>>CCn1ncc2c(O)c(C(=O)O)cnc21",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1cnn(-c2cc(C(=O)Nc3cc(C(C)(C)C)cc(NS(C)(=O)=O)c3OC)ccc2C)c1.CO.Cl.[Na+].[OH-]>>COc1c(NC(=O)c2ccc(C)c(-n3cc(C(=O)O)cn3)c2)cc(C(C)(C)C)cc1NS(C)(=O)=O",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN(C)C=O.C[C@H](N)c1nc2ccn(C)c2cc1C1CCOCC1.Cc1nc(N)nc(Cl)c1C#N>>Cc1nc(N)nc(N[C@@H](C)c2nc3ccn(C)c3cc2C2CCOCC2)c1C#N",
        "output": "110"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)Cc1cn(C)c2c1c(=O)n(C)c(=O)n2C.Cl>>Cn1c(=O)c2c(CC(=O)O)cn(C)c2n(C)c1=O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C(N)C=C(CCOC)CP(=O)(O)O.O>>COCCC(=CC(N)C(=O)O)CP(=O)(O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.ClCCl.Cn1cc(C(=O)O)c(C(F)(F)F)c1.Nc1ccccc1-c1ccccc1.O=C(Cl)C(=O)Cl>>Cn1cc(C(=O)Nc2ccccc2-c2ccccc2)c(C(F)(F)F)c1",
        "output": "739"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.CN(C)c1ccncc1.COc1ccc(OC)c2c(N)ccnc12>>COc1ccc(OC)c2c(NC(C)=O)ccnc12",
        "output": "6"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(C)=O.C[C@@H](O)CNC[C@H](CCc1c(F)cccc1NC(=O)[C@@H](N=[N+]=[N-])[C@@H](c1ccc(Cl)cc1)C1CCOCC1)NS(=O)(=O)C1CC1.ClCCl.O>>C[C@@H](O)CN(C[C@H](CCc1c(F)cccc1NC(=O)[C@@H](N=[N+]=[N-])[C@@H](c1ccc(Cl)cc1)C1CCOCC1)NS(=O)(=O)C1CC1)C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C[C@@]1(c2cc(N)ccc2F)CS(=O)(=O)CC(N)=N1.O=C(O)c1ccc(Cl)cn1>>C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS(=O)(=O)CC(N)=N1",
        "output": "985"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(CN)cc1.CC(C)O.ClCCl.O=Cc1ccc(F)cc1.[BH4-].[Na+]>>CC(C)(C)OC(=O)NCc1ccc(CNCc2ccc(F)cc2)cc1",
        "output": "683"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(NC(CCC(F)(F)F)c2ccc(-c3ncc(C(F)(F)F)cn3)cc2C)cc1.Cl.[Na+].[OH-]>>Cc1cc(-c2ncc(C(F)(F)F)cn2)ccc1C(CCC(F)(F)F)Nc1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nncn2[C@H]2CCNC2)cc1.CC(C)=O.CO.[BH3-]C#N.[Na+]>>CC(C)N1CC[C@H](n2cnnc2-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)C1",
        "output": "187"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)[Si](C)(C)Oc1cccc2[nH]ccc12.CN(C)c1ccncc1>>CC(C)(C)OC(=O)n1ccc2c(O[Si](C)(C)C(C)(C)C)cccc21",
        "output": "748"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NCc1cc2ncc(NC(=O)C3CCOCC3)n2cc1-c1ccc(Cl)cc1Cl.Cl>>NCc1cc2ncc(NC(=O)C3CCOCC3)n2cc1-c1ccc(Cl)cc1Cl",
        "output": "538"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.COc1ccc(C(=O)Cl)cc1.Cc1ccccc1.OC1CCN(Cc2ccccc2)CC1>>COc1ccc(C(=O)OC2CCN(Cc3ccccc3)CC2)cc1",
        "output": "51"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.O=C(Oc1cc(Cl)c(O)c(I)c1)c1ccccc1.OCCCOc1ccc(C(F)(F)F)cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(Oc1cc(Cl)c(OCCCOc2ccc(C(F)(F)F)cn2)c(I)c1)c1ccccc1",
        "output": "478"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CCO.COc1ccc(C(C)=O)cc1.Cl.NO.[Na+]>>COc1ccc(/C(C)=N\\O)cc1",
        "output": "212"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(C)=O.CCOC(=O)CCCBr.O=C([O-])[O-].O=Cc1ccc(O)cc1.[K+].[K+]>>CCOC(=O)CCCOc1ccc(C=O)cc1",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCI.Cn1c(=O)cc(Cl)[nH]c1=O>>CCn1c(Cl)cc(=O)n(C)c1=O",
        "output": "326"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.FC(F)(F)c1ccc(Nc2ncnc3c2CN(Cc2ccccc2)CC3)cn1.[OH-].[OH-].[Pd+2]>>FC(F)(F)c1ccc(Nc2ncnc3c2CNCC3)cn1",
        "output": "84"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COC(=O)C1(NC(=O)c2sc(-c3ccc(OC)cc3)cc2NC(=O)Nc2c(C)cc(C)cc2C)CC1.[Li+].[OH-]>>COc1ccc(-c2cc(NC(=O)Nc3c(C)cc(C)cc3C)c(C(=O)NC3(C(=O)O)CC3)s2)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN[C@@H]1CCCC[C@H]1NC.CO.O=c1c2cc(Cc3ccc(Cl)nc3)c3ccccc3c2ncn1[C@@H]1CCCC[C@H]1O.[Cu]I>>COc1ccc(Cc2cc3c(=O)n([C@@H]4CCCC[C@H]4O)cnc3c3ccccc23)cn1",
        "output": "433"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1ccc(-n2ccnc2)cc1.Cl>>O=C(O)c1ccc(-n2ccnc2)cc1",
        "output": "5"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)CN/C(=N/C(=O)c1ccc(F)c(F)c1)Nc1cc(-c2ccc(CO[Si](C)(C)C(C)(C)C)cc2)n[nH]1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>CC(C)CN/C(=N/C(=O)c1ccc(F)c(F)c1)Nc1cc(-c2ccc(CO)cc2)n[nH]1",
        "output": "708"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.Nc1ccc2c(c1)CCN2C(=O)Cc1ccccn1.O.O.O=C(O)c1ccccc1N1CCCC1.On1nnc2ccccc21>>O=C(Nc1ccc2c(c1)CCN2C(=O)Cc1ccccn1)c1ccccc1N1CCCC1",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CCOC(=O)N(C)C1CCN(Cc2ccccc2)CC1.[Pd]>>CCOC(=O)N(C)C1CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CC(C1OCCO1)[C@H]1CC[C@H]2[C@@H]3C=C[C@@]4(O)C[C@@H](O)C[C@H](O)[C@]4(C)[C@H]3CC[C@]12C.c1ccncc1>>CC(=O)O[C@H]1C[C@H](O)[C@]2(C)[C@H]3CC[C@]4(C)[C@@H](C(C)C5OCCO5)CC[C@H]4[C@@H]3C=C[C@@]2(O)C1",
        "output": "254"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN1CCNCC1.O.O=[N+]([O-])c1ccc(F)cc1Br>>CN1CCN(c2ccc([N+](=O)[O-])c(Br)c2)CC1",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(F)cc1Br.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>Fc1ccc(CBr)c(Br)c1",
        "output": "29"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.Cn1nc(NS(C)(=O)=O)c2c(Cl)ccc(-c3cccnc3[C@H](Cc3cc(F)cc(F)c3)NC(=O)C(F)(F)F)c21.O=C(OO)c1cccc(Cl)c1>>Cn1nc(NS(C)(=O)=O)c2c(Cl)ccc(-c3ccc[n+]([O-])c3[C@H](Cc3cc(F)cc(F)c3)NC(=O)C(F)(F)F)c21",
        "output": "262"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.C[N+](C)(C)Cc1ccccc1.C[N+](C)(C)Cc1ccccc1.C[N+](C)(C)Cc1ccccc1.Cc1ccc(F)c(N)c1.ClCCl.O=C([O-])[O-].[Br-].[Br-].[Br-].[Ca+2]>>Cc1cc(N)c(F)cc1Br",
        "output": "784"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.Cn1nccc1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1O.OCCN1CCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cn1nccc1-c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1OCCN1CCCC1",
        "output": "478"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COCOc1ccc(C(F)(F)F)cc1C=O.[BH4-].[Na+]>>COCOc1ccc(C(F)(F)F)cc1CO",
        "output": "356"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(N)CO.CCN(CC)CC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.O.O=C(O)c1nn(-c2ccc(F)cc2F)c2c1C1CCC2C1>>CC(C)(CO)NC(=O)c1nn(-c2ccc(F)cc2F)c2c1C1CCC2C1",
        "output": "816"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CO.Cl.Cl.NCCSSCCN>>CC(C)(C)OC(=O)NCCSSCCN",
        "output": "631"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.N#CCBr.O=C([O-])[O-].O=c1c(C2=NS(=O)(=O)c3cc(O)ccc3N2)c(O)c2ccccc2n1NCC1CC1.[I-].[K+].[K+]>>N#CCOc1ccc2c(c1)S(=O)(=O)N=C(c1c(O)c3ccccc3n(NCC3CC3)c1=O)N2",
        "output": "802"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOc1cc(C(=O)OC)cc(-c2nnn[nH]2)c1.CO.Cl.[Na+].[OH-]>>CCOc1cc(C(=O)O)cc(-c2nnn[nH]2)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.CC#N.CC(C)(C)OC(=O)n1nc(-c2cc3cc(OCCBr)ccc3n2C(=O)OC(C)(C)C)c2cc(OCc3ccccc3)ccc21.ClCCl.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CC(C)(C)OC(=O)n1nc(-c2cc3cc(OCCN4CCOCC4)ccc3n2C(=O)OC(C)(C)C)c2cc(OCc3ccccc3)ccc21",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CO.COC(=O)c1ccc(CNc2ccc(-c3nc4ccccc4o3)cc2[N+](=O)[O-])cc1.ClC(Cl)Cl.O=C([O-])O.[Fe].[Na+]>>COC(=O)c1ccc(CNc2ccc(-c3nc4ccccc4o3)cc2N)cc1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#C[Si](C)(C)C.CCN(CC)CC.CN(C)C=O.Cc1ccc(NC(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1I.[Cu]I>>Cc1ccc(NC(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#C[Si](C)(C)C",
        "output": "826"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#Cc1cnc(C2CCCN2C(=O)C(NC(=O)OC)C(C)C)[nH]1.CCN(CC)CC.CN(C)C=O.COC(=O)NC(C(=O)N1CCCC1c1ncc(C#Cc2ccc(Br)cc2)[nH]1)C(C)C.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COC(=O)NC(C(=O)N1CCCC1c1ncc(C#Cc2ccc(C#Cc3cnc(C4CCCN4C(=O)C(NC(=O)OC)C(C)C)[nH]3)cc2)[nH]1)C(C)C",
        "output": "659"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cl.Cl[Sn]Cl.O.O.O=[N+]([O-])c1ccc(-c2ccn[nH]2)cc1>>Nc1ccc(-c2ccn[nH]2)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1sc(-n2cnc3ccc(OC4CCN(C(=O)OC(C)(C)C)CC4)cc32)cc1O[C@H](C)c1ccccc1C(F)(F)F.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+].[Na+].[OH-]>>COC(=O)c1sc(-n2cnc3ccc(OC4CCNCC4)cc32)cc1O[C@H](C)c1ccccc1C(F)(F)F",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.CS(=O)c1nc(CN2CCOCC2)cc(Nc2nc3ccc([N+](=O)[O-])cc3s2)n1.N[C@H]1CC[C@H](O)CC1>>O=[N+]([O-])c1ccc2nc(Nc3cc(CN4CCOCC4)nc(N[C@@H]4CC[C@@H](O)CC4)n3)sc2c1",
        "output": "666"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1ccc2nccc(N3CCCCC3)c2c1.C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc3nccc(N4CCCCC4)c3c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCc1nc(Cl)nc(Nc2cccc(C(C)C)c2)n1.CS(=O)(=O)N1CCC(N)CC1.CS(C)=O.Cl.O.O=C([O-])[O-].[K+].[K+]>>CCCc1nc(Nc2cccc(C(C)C)c2)nc(NC2CCN(S(C)(=O)=O)CC2)n1",
        "output": "578"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.Br[Cu]Br.CC(=O)c1cccc2ccccc12.CCOC(C)=O.ClC(Cl)Cl>>O=C(CBr)c1cccc2ccccc12",
        "output": "360"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccc(-c2nc3ccccc3s2)cc1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>BrCc1ccc(-c2nc3ccccc3s2)cc1",
        "output": "29"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Nc1ccc(N)cc1.CC(C)(C)OC(=O)N1CCC(=O)CC1>>CC(=O)Nc1ccc(NC2CCN(C(=O)OC(C)(C)C)CC2)cc1",
        "output": "469"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(C)c1cc(NC(=O)N2CCCNCC2)on1.CN(C)C=O.CN(C)c1ccncc1.ClCCCl.O.O=C(O)C1CCOCC1.On1nnc2ccccc21>>CCC(C)c1cc(NC(=O)N2CCCN(C(=O)C3CCOCC3)CC2)on1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CC(C)(C)C(=O)SCC1CCCCCCCSC[C@@H](C(=O)O)NC1=O.CN(C)C=O.O.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)(C)C(=O)SCC1CCCCCCCSC[C@@H](C(=O)OCc2ccccc2)NC1=O",
        "output": "403"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.CN(C)C=O.O.O=C(O)c1ccc(-c2nc3ccccc3o2)cc1.O=S(Cl)Cl>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(-c3nc4ccccc4o3)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN.COc1ccc(-c2ccc3c(c2)COC3=O)c(OCC(C)(C)C(=O)O)c1OC.Cl.ClCCl.O.O.On1nnc2ccccc21>>CNC(=O)C(C)(C)COc1c(-c2ccc3c(c2)COC3=O)ccc(OC)c1OC",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1n[nH]c(=O)c(-c2cc(F)cc(F)c2F)c1-c1ccc(Cl)cc1.O=P(Cl)(Cl)Cl>>Cc1nnc(Cl)c(-c2cc(F)cc(F)c2F)c1-c1ccc(Cl)cc1",
        "output": "537"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NCCOc1cc(Br)cc([N+](=O)[O-])c1.COCCOC.Cl[Pd]Cl.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cn1cc(-c2cc(OCCNC(=O)OC(C)(C)C)cc([N+](=O)[O-])c2)cn1",
        "output": "971"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC1(C)O[C@@H]2[C@H](O1)[C@@H](CN)O[C@H]2n1cnc2c(N)ncnc21.CC=O.ClCCCl.O=C([O-])O.[Na+].[Na+]>>CCNC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21",
        "output": "426"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOc1ccc(C(=O)OC)c(Oc2ccc(Cl)cc2Cl)n1.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Mg+2]>>CCOc1ccc(CO)c(Oc2ccc(Cl)cc2Cl)n1",
        "output": "522"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(Br)cc(O[Si](C)(C)C(C)(C)C)c1.[BH4-].[Cl-].[Li+].[NH4+]>>CC(C)(C)[Si](C)(C)Oc1cc(Br)cc(CO)c1",
        "output": "444"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=Cc1ccc(C(F)(F)F)nc1.CN1CCCC1=O.Cc1ccc2[nH]c3c(c2c1)CN(C)C(C)C3.O.[K+].[OH-]>>Cc1ccc2c(c1)c1c(n2CCc2ccc(C(F)(F)F)nc2)CC(C)N(C)C1",
        "output": "986"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.CCOP(=O)(Cn1c(=O)c(=O)[nH]c2cc([N+](=O)[O-])c(F)cc21)OCC>>CCOP(=O)(Cn1c(=O)c(=O)[nH]c2cc([N+](=O)[O-])c(N3CCOCC3)cc21)OCC",
        "output": "676"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.Cl.ClCCl.N#Cc1cccc(N2CCNCC2)c1.O.O=C(O)c1[nH]c(S)nc1-c1ccccc1.On1nnc2ccccc21>>N#Cc1cccc(N2CCN(C(=O)c3[nH]c(S)nc3-c3ccccc3)CC2)c1",
        "output": "729"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CN(C)C=O.COc1cc(-c2cnc(C)n2C)ccc1N.Cn1cc(-c2ccc3cnc(Cl)nc3n2)cn1.O=C([O-])[O-].[K+].[K+].[Pd+2]>>COc1cc(-c2cnc(C)n2C)ccc1Nc1ncc2ccc(-c3cnn(C)c3)nc2n1",
        "output": "592"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC(CBr)CC1.CN(C)C=O.Nc1nc(Cl)c2c(C(F)(F)F)c[nH]c2n1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCC(Cn2cc(C(F)(F)F)c3c(Cl)nc(N)nc32)CC1",
        "output": "327"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CI.CN(C)C=O.O.O=C(O)Cc1ccccc1I.O=C([O-])[O-].[K+].[K+]>>COC(=O)Cc1ccccc1I",
        "output": "415"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCC.CCCCCc1c(C(C)C)cc(C(C)C)c(C(C)O)c1-c1ccc(F)cc1.CCOC(C)=O.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CCCCCc1c(C(C)C)cc(C(C)C)c(C(C)=O)c1-c1ccc(F)cc1",
        "output": "32"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.CCOC(C)=O.ClCCl.N.O=C(O)CCCCCCN1C(=O)CCC[C@@H]1/C=C/C(O)Cc1ccccc1>>NC(=O)CCCCCCN1C(=O)CCC[C@@H]1/C=C/C(O)Cc1ccccc1",
        "output": "313"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.COCCCN1CCOc2ccc(CO[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)[C@@H](CCC(C)=O)C[C@@H]3c3ccc(OC)cc3)cc21>>COCCCN1CCOc2ccc(CO[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)[C@@H](CCC(C)O)C[C@@H]3c3ccc(OC)cc3)cc21",
        "output": "91"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCCCC1.CO.ClCCl.N.Nc1c(Br)cc(C[C@@H](N)C(=O)N2CCC(N3CCCCC3)CC2)cc1Br>>Nc1c(Br)cc(C[C@@H](N)CN2CCC(N3CCCCC3)CC2)cc1Br",
        "output": "112"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1csc(CN2CCC(Nc3ncnc4ccc(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)cc34)CC2)c1.[Na+].[OH-]>>O=C(O)c1csc(CN2CCC(Nc3ncnc4ccc(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)cc34)CC2)c1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.Cc1oc2c(C)c(C)c(N)c(C)c2c1-c1ccc(C(C)C)cc1.O=C(Cl)c1ccccc1>>Cc1oc2c(C)c(C)c(NC(=O)c3ccccc3)c(C)c2c1-c1ccc(C(C)C)cc1",
        "output": "11"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)NCCc1ccc(N)cc1.CO.Cc1ccccc1.O=Cc1ccccc1.[BH3-]C#N.[Na+]>>CC(C)(C)OC(=O)NCCc1ccc(NCc2ccccc2)cc1",
        "output": "359"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cc(F)c(F)c(OCF)c1F.N>>NC(=O)c1cc(F)c(F)c(OCF)c1F",
        "output": "67"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)/C=C/C(=O)c1nn(-c2ccc(OC(F)(F)F)cc2)ccc1=O.NNc1cccc(S(=O)(=O)C(F)(F)F)c1>>O=c1ccn(-c2ccc(OC(F)(F)F)cc2)nc1-c1ccnn1-c1cccc(S(=O)(=O)C(F)(F)F)c1",
        "output": "984"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CNC(=O)c1c(-c2ccc(Oc3ccc(F)cc3)nc2)oc2cc(N(C)S(C)(=O)=O)c(Br)cc12.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CNC(=O)c1c(-c2ccc(Oc3ccc(F)cc3)nc2)oc2cc(N(C)S(C)(=O)=O)c(B3OC(C)(C)C(C)(C)O3)cc12",
        "output": "942"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](N)C1.Cn1c(-c2cncc(C=O)c2)c(C#N)c2ccc(Cl)cc21>>Cn1c(-c2cncc(CN[C@H]3CCN(C(=O)OC(C)(C)C)C3)c2)c(C#N)c2ccc(Cl)cc21",
        "output": "441"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCC.O=C(O)c1cc(=O)c2cc3[nH]c(=O)oc3cc2[nH]1.c1ccc(CC2CCNCC2)cc1>>O=C(c1cc(=O)c2cc3[nH]c(=O)oc3cc2[nH]1)N1CCC(Cc2ccccc2)CC1",
        "output": "605"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cccc(F)c1-c1ccccc1Cl.Oc1cccc(Cl)c1-c1ccccc1Cl>>Oc1cccc(F)c1-c1ccccc1Cl",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#C[C@@H](CC(=O)OCC)c1ccc(O)cc1.CN(C)C=O.Cc1cccc(C)c1-c1nc2ccc(CCl)cn2n1.O=C([O-])[O-].[Cs+].[Cs+]>>CC#C[C@@H](CC(=O)OCC)c1ccc(OCc2ccc3nc(-c4c(C)cccc4C)nn3c2)cc1",
        "output": "678"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC1c2cccn2-c2ccc(F)cc2N1S(=O)(=O)c1ccc(O)c(C)c1.ClCCl.O=C1CCC(=O)N1Br>>CCC1c2ccc(Br)n2-c2ccc(F)cc2N1S(=O)(=O)c1ccc(O)c(C)c1",
        "output": "779"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)Cn1c(Cl)cnc(N[C@@H](Cc2ccccc2)CN(C)C)c1=O.Cl.[Li+].[OH-]>>CN(C)C[C@H](Cc1ccccc1)Nc1ncc(Cl)n(CC(=O)O)c1=O",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(=O)C1CCNCC1.ClCCl.Nc1cnccc1C=O.[Na+]>>CCOC(=O)C1CCN(Cc2ccncc2N)CC1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1ccc2nc(-c3cccc4c3-c3ccccc3C4=O)[nH]c2c1.ClCCl.O>>O=C1c2ccccc2-c2c1cccc2-c1nc2ccc(O)cc2[nH]1",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCN.Clc1ccncc1.O>>CCCCNc1ccncc1",
        "output": "78"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C[C@@H](CO)NC(=O)OC(C)(C)C.CCN(CC)CC.CS(C)=O.ClCCl>>CC(C)C[C@@H](C=O)NC(=O)OC(C)(C)C",
        "output": "142"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCCCBr.CN(C)C=O.Nc1nccc2[nH]c(Sc3ccc(Cl)cc3Cl)nc12.O=C([O-])[O-].[Cs+].[Cs+]>>Nc1nccc2c1nc(Sc1ccc(Cl)cc1Cl)n2CCCBr",
        "output": "495"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(=O)c1[nH]c2c(Br)c(Cl)ccc2c1CCCOc1cc(C)c(Cl)c(C)c1.CCOCC.CN(C)C=O.[K+]>>CCOC(=O)c1[nH]c2c(B3OC(C)(C)C(C)(C)O3)c(Cl)ccc2c1CCCOc1cc(C)c(Cl)c(C)c1",
        "output": "943"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cnn(-c2ccccn2)c1.[Li+].[OH-]>>O=C(O)c1cnn(-c2ccccn2)c1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.Clc1nc2ccccc2c2c1ncn2CCC1CCNCC1.O=C(O)C(F)(F)F.c1ccncc1>>CC(=O)N1CCC(CCn2cnc3c(Cl)nc4ccccc4c32)CC1",
        "output": "369"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)C(O)C1Sc2ccccc2NC1=O.O.[Na+].[OH-]>>O=C(O)C(O)C1Sc2ccccc2NC1=O",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN.CN(C)c1ccncc1.ClCCl.O=C(O)c1ccc(OCC(=O)C23CC4CC(CC(C4)C2)C3)cc1>>CNC(=O)c1ccc(OCC(=O)C23CC4CC(CC(C4)C2)C3)cc1",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCO.Cc1ccc(C)c(N2CCN(c3cc(Cl)c(C(=O)NCc4cccc(CN(C)C)c4)cc3[N+](=O)[O-])CC2)c1.[Fe]>>Cc1ccc(C)c(N2CCN(c3cc(Cl)c(C(=O)NCc4cccc(CN(C)C)c4)cc3N)CC2)c1",
        "output": "489"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.CO.COc1ccc(-c2ccc(-c3nc(-c4ccc(C(F)(F)F)cc4)oc3C)cc2)cc1.ClCCl.O>>Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1-c1ccc(-c2ccc(O)cc2)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COc1cc2c(ccn2C2C=CCCC2)cn1.[Pd]>>COc1cc2c(ccn2C2CCCCC2)cn1",
        "output": "143"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#C[C@]1(C)CCc2c(C)c(O)c(C)c(C)c2O1.CC(C)=O.COS(=O)(=O)OC.[NH4+].[Na+].[OH-].[OH-]>>C#C[C@]1(C)CCc2c(C)c(OC)c(C)c(C)c2O1",
        "output": "317"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC1CCCCC1N(Cc1ccc(C(=O)[O-])cc1)S(=O)(=O)c1ccc(C(F)(F)F)nc1.O.O.[Li+].[OH-]>>CC1CCCCC1N(Cc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccc(C(F)(F)F)nc1",
        "output": "151"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc(Br)ccc1N.Cl.Cl[Sn]Cl.O=N[O-].[Na+].[Na+].[OH-]>>Cc1cc(Br)ccc1NN",
        "output": "109"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4cc(C(N)=O)ccn4)n3)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>NC(=O)c1ccnc(CCc2nc(Nc3ccc(C4CCNCC4)cc3)ncc2C(F)(F)F)c1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCn1ncc2c(C(=O)O)cc(C3CC3)nc21.CN1CCOCC1.CS(C)=O.Cc1cc(C)c(CN)c(=O)[nH]1.ClCCCl.On1nnc2cccnc21>>CCCn1ncc2c(C(=O)NCc3c(C)cc(C)[nH]c3=O)cc(C3CC3)nc21",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COCCN1CCN(CC(=O)O)CC1.Cl.O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2ccccc2)CN1>>COCCN1CCN(CC(=O)N2C[C@H](Cc3ccccc3)C[C@H]2C(=O)Nc2ccc(Oc3ccc(F)cc3)cc2)CC1",
        "output": "297"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCCCCCCCOc1ccc(C2CCCNC2)cc1.CCOC(=O)CCCBr.O=C([O-])[O-].[Cs+].[Cs+]>>CCCCCCCCOc1ccc(C2CCCN(CCCC(=O)OCC)C2)cc1",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN.CCN(C(C)C)C(C)C.Fc1cc(F)cc(C2COCc3c(Cl)nc(Cl)nc32)c1>>CCNc1nc(Cl)nc2c1COCC2c1cc(F)cc(F)c1",
        "output": "110"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)(C)C(=O)OC)S(=O)(=O)c1ccccc1C.CO.O.O.[Li]O>>CCN(C(C)(C)C(=O)O)S(=O)(=O)c1ccccc1C",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)C1(S(=O)(=O)c2ccc(-c3ccc(OC(F)(F)C(F)F)cc3)cc2)CCNCC1.CCI.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O>>CCN1CCC(C(=O)OC(C)(C)C)(S(=O)(=O)c2ccc(-c3ccc(OC(F)(F)C(F)F)cc3)cc2)CC1",
        "output": "184"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccccc1.CC(C)(C)OC(=O)N1CCCCC1C(=O)O.CCN(CC)CC.CN(C)C=O>>CC(C)(C)OC(=O)N1CCCCC1C(=O)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrC(Br)(Br)Br.CCCc1cc(CO)ccc1OC(C(=O)OC)c1ccccc1.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCc1cc(CBr)ccc1OC(C(=O)OC)c1ccccc1",
        "output": "750"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCC.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.CN.CN(C)C=O.CS(=O)(=O)c1ccc(Oc2cc(OC3CCOCC3)c3[nH]c(C4=NCC(CC(=O)O)S4)cc3c2)cn1.Cl.Cl.Cl.O.On1nnc2ccccc21>>CNC(=O)CC1CN=C(c2cc3cc(Oc4ccc(S(C)(=O)=O)nc4)cc(OC4CCOCC4)c3[nH]2)S1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.CC(=O)O.COc1ccc(C(=O)c2sc(N)nc2-c2ccco2)cn1.O=C([O-])[O-].[Na+].[Na+]>>Nc1nc(-c2ccco2)c(C(=O)c2ccc(=O)[nH]c2)s1",
        "output": "758"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC(=O)CC1.CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C.CCO.O.O=S(=O)(C1CCCNC1)N1CCOCC1.[BH3-]C#N.[Na+]>>CC(C)(C)OC(=O)N1CCC(N2CCCC(S(=O)(=O)N3CCOCC3)C2)CC1",
        "output": "187"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCCCC1(COc2ccc([N+](=O)[O-])cc2)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1.CO.[H][H].[Pd].c1ccccc1>>CCCCCCCCC1(COc2ccc(N)cc2)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1",
        "output": "202"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(CCCN1CCC(NS(=O)(=O)c2ccccc2)CC1)c1ccccc1.[BH4-].[Na+]>>O=S(=O)(NC1CCN(CCCC(O)c2ccccc2)CC1)c1ccccc1",
        "output": "24"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(F)c([N+](=O)[O-])c1.CO.[C].[Pd]>>CC(C)(C)OC(=O)NCc1ccc(F)c(N)c1",
        "output": "71"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC2=NCCCN2CC1.CC(=O)N(C)C.CC(C)CCBr.O=c1cc(OCc2ccccc2)cc[nH]1>>CC(C)CCn1ccc(OCc2ccccc2)cc1=O",
        "output": "470"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CCNC(=O)c1c(C(C)C)[nH]c(C=O)c1-c1ccccc1.O=C1Cc2cc(Br)ccc2N1>>CCN(CC)CCNC(=O)c1c(C(C)C)[nH]c(C=C2C(=O)Nc3ccc(Br)cc32)c1-c1ccccc1",
        "output": "440"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(C)N1C(=O)C(C)(C)c2ccc(F)cc21.O=S(=O)(O)O.O=[N+]([O-])O>>CC(C)N1C(=O)C(C)(C)c2cc([N+](=O)[O-])c(F)cc21",
        "output": "21"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCN(CC)CC.CCOP(=O)(Cl)OCC.COc1ccc(OC)c(C=CC(=O)O)c1.Cc1cc(N)cc(C)c1O.O=C([O-])O.[Na+]>>COc1ccc(OC)c(C=CC(=O)Nc2cc(C)c(O)c(C)c2)c1",
        "output": "170"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.Cc1c(O)cccc1O.O=C1CCC(=O)N1Cl>>Cc1c(O)ccc(Cl)c1O",
        "output": "121"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(C)(C#N)Nc1ccc(Br)cn1.Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(B2OC(C)(C)C(C)(C)O2)c1.ClCCl.Cl[Pd]Cl.O.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCC(C)(C#N)Nc1ccc(-c2cc(C)cc(Nc3nccc(C(F)(F)F)n3)c2)cn1",
        "output": "938"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COc1cc(C2=CCN(C(=O)OC(C)(C)C)CC2)ccc1NC(=O)OC(C)(C)C.[Pd]>>COc1cc(C2CCN(C(=O)OC(C)(C)C)CC2)ccc1NC(=O)OC(C)(C)C",
        "output": "806"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.N.O=S(=O)(Cl)c1cccc2c(Cl)nccc12>>NS(=O)(=O)c1cccc2c(Cl)nccc12",
        "output": "245"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC(=O)Nc1cc(C)c(O)c(C)c1.CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc(C=O)cc1CCl.O=C([O-])[O-].[I-].[K+].[K+]>>COc1ccc(C=O)cc1COc1c(C)cc(NC(C)=O)cc1C",
        "output": "49"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1csc2c(N3CCOCC3)nc(Cl)nc12.Cc1nc(N)ncc1B1OC(C)(C)C(C)(C)O1>>Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2scc(C)c2n1",
        "output": "973"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.NC(=O)CCc1cccc(OCc2ccccc2)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCCCc1cccc(OCc2ccccc2)c1",
        "output": "112"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cccc(I)c1.Clc1ccc2cc[nH]c2c1>>Cc1cccc(-n2ccc3ccc(Cl)cc32)c1",
        "output": "267"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cc3c(cc2F)nc(COc2ccccc2)n3Cc2ccc(OC(F)(F)F)cc2)CC1.O.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>Fc1cc2nc(COc3ccccc3)n(Cc3ccc(OC(F)(F)F)cc3)c2cc1N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.CC(C)(C)O[Na].Cc1c(S(=O)(=O)N2CCN(c3ncccc3C(F)(F)F)CC2)sc2ccc(Cl)cc12.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]>>Cc1c(S(=O)(=O)N2CCN(c3ncccc3C(F)(F)F)CC2)sc2ccc(N3CCOCC3)cc12",
        "output": "105"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CCBr.CCOC(C)=O.CN1CCCC1=O.COc1cc2c(cc1O)C(C)(C)CC2=O.O.O=C([O-])[O-].[K+].[K+]>>C#CCOc1cc2c(cc1OC)C(=O)CC2(C)C",
        "output": "154"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCN(CCNC2=NC(=O)CS2)CC1.O=Cc1ccc2c(c1)c(I)nn2Cc1ccc(C(F)(F)F)cc1C(F)(F)F>>CN1CCN(CCNC2=NC(=O)C(=Cc3ccc4c(c3)c(I)nn4Cc3ccc(C(F)(F)F)cc3C(F)(F)F)S2)CC1",
        "output": "314"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)n1cc(C(=O)c2cncc(N)c2)c2cnc(N)nc21.CCN(C(C)C)C(C)C.O=C(O)Cc1ccc(Br)cn1>>CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Br)cn3)c2)c2cnc(N)nc21",
        "output": "724"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)c1ccncc1.CO.Cl.ClCCl.N#Cc1ccc(CCCCCC(=O)O)cc1>>COC(=O)CCCCCc1ccc(C#N)cc1",
        "output": "195"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cccc(C(=O)Cl)c1.Nc1ccccn1>>COc1cccc(C(=O)Nc2ccccn2)c1",
        "output": "463"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)CC(C)C.CCOC(=O)CBr.O.O=C([O-])[O-].[I-].[Na+].[Na+].[Na+].c1ccc2c(c1)Cc1ccccc1N1CCNCC21>>CCOC(=O)CN1CCN2c3ccccc3Cc3ccccc3C2C1",
        "output": "467"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)[O-].CCCC(N)CO.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1C.Cc1ccnc(Cl)c1.[K+]>>CCCC(CO)Nc1cc(C)ccn1",
        "output": "70"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CNC(=O)CCc1ccc(O)cc1.CO.O.[Li+].[OH-]>>O=C(O)CNC(=O)CCc1ccc(O)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccccc1.C[N+](=O)[O-].Cc1cccc(C(=O)Cl)c1.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Sc+3]>>COc1ccc(C(=O)c2cccc(C)c2)cc1",
        "output": "61"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Br.CC#N.CCOC(C)=O.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3ccc(N)c(C(F)F)c3)S(C)(=O)=O)c(C3CC3)cc12.O.O=N[O-].[Cu]Br.[Na+]>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3ccc(Br)c(C(F)F)c3)S(C)(=O)=O)c(C3CC3)cc12",
        "output": "373"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCO.CCN(CC)CC.Cc1cccc(-c2cc(Cl)nc(N)n2)c1C.Cl.NC1(Cc2ccc(Cl)cc2)CC1>>Cc1cccc(-c2cc(NC3(Cc4ccc(Cl)cc4)CC3)nc(N)n2)c1C",
        "output": "166"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=CC(=O)O.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1>>CC(C)=CC(=O)N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1",
        "output": "549"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COCCOC.Cc1cc(OC2CCCCO2)ccc1-c1cccc(C=O)c1.[BH4-].[Cl-].[NH4+].[Na+]>>Cc1cc(OC2CCCCO2)ccc1-c1cccc(CO)c1",
        "output": "356"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cl.N#Cc1ccc(-c2ccc(C(=O)CCC(=O)O)cc2)cc1.NO.O=C([O-])[O-].[Na+].[Na+]>>N#Cc1ccc(-c2ccc(C(CCC(=O)O)=NO)cc2)cc1",
        "output": "212"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(CO)(CCl)CC1.CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)N1CCC(C=O)(CCl)CC1",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccccc1CC(=O)O.Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1.O=S(Cl)Cl>>COc1ccccc1CC(=O)Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1",
        "output": "365"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C([O-])[O-].Oc1ccc(I)cc1.[K+].[K+]>>Ic1ccc(OCc2ccccc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1cc(Br)cc(OC(C)C)c1C.Cl.[Na+].[OH-]>>Cc1c(OC(C)C)cc(Br)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#CCCc1ccc2ccccc2n1.Cc1cccc(Br)n1>>Cc1cccc(C#CCCc2ccc3ccccc3n2)n1",
        "output": "777"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCO.CCOC(=O)C1(Sc2ccnc3ccc(Br)cc23)CCC1.Cl.O.O.[Li+].[OH-]>>O=C(O)C1(Sc2ccnc3ccc(Br)cc23)CCC1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C(=O)O)c1ccc(C2(O[Si](C)(C)C(C)(C)C)CC2)c(F)c1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cl.ClCCl.NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1.On1nnc2ccccc21>>CC(C(=O)NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1)c1ccc(C2(O[Si](C)(C)C(C)(C)C)CC2)c(F)c1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(-c2oncc2C(=O)O)cc1.OC1(c2ccccc2)CCNCC1>>Cc1ccc(-c2oncc2C(=O)N2CCC(O)(c3ccccc3)CC2)cc1",
        "output": "975"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.Cc1cccc(C)c1OC1CNC1.Cl>>CC(=O)N1CC(Oc2c(C)cccc2C)C1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(CC(=O)NCCCC)ccc21.CCO.[Na+].[OH-].[Pd]>>CCCCNC(=O)Cc1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2CCC",
        "output": "116"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.O=C(C1COc2ccccc2O1)N1CCN(c2cccc(Cl)c2Cl)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>Clc1cccc(N2CCN(CC3COc4ccccc4O3)CC2)c1Cl",
        "output": "363"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCC[C@@H](O)C(F)(F)F.CCN(CC)CC.ClCCl.O=C(Cl)c1ccc(OCc2ccccc2)cc1>>CCCCCC[C@@H](OC(=O)c1ccc(OCc2ccccc2)cc1)C(F)(F)F",
        "output": "51"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C=O.CS(=O)(=O)Cl.O=C(CCl)Nc1cccc2ccc(O)cc12>>CS(=O)(=O)Oc1ccc2cccc(NC(=O)CCl)c2c1",
        "output": "149"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CNOC.Cl.ClCCl.Nc1cc(C(=O)O)cc(S(F)(F)(F)(F)F)c1>>CON(C)C(=O)c1cc(N)cc(S(F)(F)(F)(F)F)c1",
        "output": "828"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCCOc1cc(CCC(=O)OCC)n(Cc2ccc(F)cc2F)n1.Cc1ccccc1.[Cl-].[H-].[NH4+]>>CCCOc1cc(CCCO)n(Cc2ccc(F)cc2F)n1",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(N2CCC(N3C(=O)N[C@@H]4CCCC[C@H]43)CC2)CCNCC1.CCN(C(C)C)C(C)C.CCOC(=O)Cl.ClCCl.O=C([O-])O.[Na+]>>CCOC(=O)N1CCC(C)(N2CCC(N3C(=O)N[C@@H]4CCCC[C@H]43)CC2)CC1",
        "output": "219"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.N#CC1(n2cc(C=O)c3cccnc32)CCCC1.O.[BH4-].[Na+]>>N#CC1(n2cc(CO)c3cccnc32)CCCC1",
        "output": "476"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)Cl.ClCCl.OCc1ccncc1F>>CS(=O)(=O)OCc1ccncc1F",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCc1ccc(C2CC(C(=O)O)CN(C(=O)C3CCCC3)C2)cc1.N=C(Cc1ccccc1Cl)NO>>CCc1ccc(C2CC(c3nc(Cc4ccccc4Cl)no3)CN(C(=O)C3CCCC3)C2)cc1",
        "output": "924"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1nc(N)ncc1B1OC(C)(C)C(C)(C)O1.Clc1nc(N2CCOCC2)c2sccc2n1>>Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2sccc2n1",
        "output": "973"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.O=C(O)C=Cc1ccccc1F.[Rh]>>O=C(O)CCc1ccccc1F",
        "output": "344"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)Cl.[NH4+].[OH-]>>Cc1ccc([N+](=O)[O-])cc1S(N)(=O)=O",
        "output": "245"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=C(C)c1cncc(C(=O)O)c1.CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.ClCCl.On1nnc2ccccc21>>C=C(C)c1cncc(C(=O)NC[C@@H](O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)c1",
        "output": "674"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCOC(=O)Cl.Cc1ccccc1.NCCC(=O)O.O.O=C([O-])O.[Na+]>>C#CCOC(=O)NCCC(=O)O",
        "output": "94"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=Cc1cc2ccccc2[nH]1.[BH4-].[Na+].c1cnc2c(c1)CCCC2NC1CCC(NCc2nc3ccccc3[nH]2)CC1>>c1cnc2c(c1)CCCC2N(Cc1cc2ccccc2[nH]1)C1CCC(NCc2nc3ccccc3[nH]2)CC1",
        "output": "829"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1c(C=O)[nH]c2c1C(=O)N(CC1(O)CCN(C)CC1)CC2.O=C1Cc2c(cccc2-c2cccc(F)c2F)N1>>Cc1c(C=C2C(=O)Nc3cccc(-c4cccc(F)c4F)c32)[nH]c2c1C(=O)N(CC1(O)CCN(C)CC1)CC2",
        "output": "440"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.O=Cc1c(Cl)cc(OCc2ccccc2)cc1Cl.[BH4-].[Cl-].[NH4+].[Na+]>>OCc1c(Cl)cc(OCc2ccccc2)cc1Cl",
        "output": "356"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)Nc1nc2ccc(Oc3cccc(N)c3)c(C#N)c2s1.CC(C)(C#N)c1cc(C(=O)O)ccc1Cl.CCOC(C)=O.CN(C)C=O.O=C(Cl)C(=O)Cl>>CC(=O)Nc1nc2ccc(Oc3cccc(NC(=O)c4ccc(Cl)c(C(C)(C)C#N)c4)c3)c(C#N)c2s1",
        "output": "50"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1CCCC1=O.O=C(C1=C(F)C(F)C(F)(OCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CO)C(F)=C1F)c1ccccc1.O=[N+]([O-])c1ccc(Cl)c([N+](=O)[O-])c1>>O=C(C1=C(F)C(F)C(F)(OCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)COc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])C(F)=C1F)c1ccccc1",
        "output": "57"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc(OC)cc(N2Cc3cnc(S(C)=O)nc3NC2=O)c1.NCCNCc1ccncc1>>COc1cc(OC)cc(N2Cc3cnc(NCCNCc4ccncc4)nc3NC2=O)c1",
        "output": "666"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COCCOCCOCCOc1cc(N)cc(OC)c1.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc(Cl)n3)c(Cl)c2Cl)cc1>>COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(C)cc4)c(Cl)c3Cl)n2)cc(OC)c1",
        "output": "808"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc(F)c2c(c1OCC#N)CCC=C2.[BH4-].[Na+]>>COc1cc(F)c2c(c1OCC#N)CCCC2",
        "output": "362"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COc1ccc(C(=O)Cl)cc1OC.ClCCl.NCc1ccc(O)cc1.[Ca+2].[Cl-].[Cl-]>>COc1ccc(C(=O)NCc2ccc(O)cc2)cc1OC",
        "output": "411"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1c(Br)cc(CC(=O)O)cc1Br.O=C(Cl)C(=O)Cl.c1ccccc1>>COc1c(Br)cc(CC(=O)Cl)cc1Br",
        "output": "56"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "N#Cc1ccc(O)c(B(O)O)c1.O=Cc1cccc(Br)c1>>N#Cc1ccc(O)c(-c2cccc(C=O)c2)c1",
        "output": "837"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1NCCc2sccc21.O=C(O)c1cc2ncc(Cl)cn2n1>>CC1c2ccsc2CCN1C(=O)c1cc2ncc(Cl)cn2n1",
        "output": "663"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)c1sc(N2CCOC(CF)C2)c(C#N)c1-c1ccc(Cl)cc1Cl.O.[Na+].[OH-]>>N#Cc1c(N2CCOC(CF)C2)sc(C(=O)O)c1-c1ccc(Cl)cc1Cl",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cccc2cc(C(=O)O)c(=O)oc12.F[P-](F)(F)(F)(F)F.Nc1cccc(-c2ccc(Oc3ccccc3)cc2)c1>>COc1cccc2cc(C(=O)Nc3cccc(-c4ccc(Oc5ccccc5)cc4)c3)c(=O)oc12",
        "output": "799"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)P([c-]1cccc1)C(C)(C)C.CC(C)(C)P([c-]1cccc1)C(C)(C)C.CCOC(C)=O.Cl[Pd]Cl.O=C([O-])O.O=C([O-])[O-].OB(O)c1ccccc1.OC(c1ccccc1)(c1ccccc1)C1CCN(CCc2ccc(Br)cc2)CC1.[Fe+2].[K+].[K+].[Na+]>>OC(c1ccccc1)(c1ccccc1)C1CCN(CCc2ccc(-c3ccccc3)cc2)CC1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=[N+]([O-])c1ccccc1Oc1ccnn1-c1ccccc1.[Pd]>>Nc1ccccc1Oc1ccnn1-c1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1cccc(N)c1.ClCCl.O=Cc1ccc(Cl)cc1.[Na+]>>COc1cccc(NCc2ccc(Cl)cc2)c1",
        "output": "359"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(Cl)cc2c1NC(c1cccc(NC(C)(C)C(=O)O)c1)C(C)(C)C2.Cl.O.O.[Li+].[OH-]>>CC(C)(Nc1cccc(C2Nc3c(cc(Cl)cc3C(=O)O)CC2(C)C)c1)C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCNC(=O)Nc1cccc(Nc2ncc(CO[Si](C)(C)C(C)(C)C)c(NCCCNC(=O)OCc3ccccc3)n2)c1.CCO.CCOC(C)=O.Cl.O=C([O-])O.[Na+]>>CCNC(=O)Nc1cccc(Nc2ncc(CO)c(NCCCNC(=O)OCc3ccccc3)n2)c1",
        "output": "708"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCCCC1.CCOC(C)=O.Clc1cncc(Cl)n1.Oc1ccccc1-c1ccccc1>>Clc1cncc(Oc2ccccc2-c2ccccc2)n1",
        "output": "210"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COC(=O)c1ccc([C@H]2C[C@@H](NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)CCO2)cc1.[Na+].[OH-]>>O=C(O)c1ccc([C@H]2C[C@@H](NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)CCO2)cc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COS(=O)(=O)OC.Cl.O.O=C(O)c1cc(OCc2ccccc2)ccc1O.O=C([O-])[O-].[K+].[K+].[Na+].[OH-]>>COc1ccc(OCc2ccccc2)cc1C(=O)O",
        "output": "317"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCI.COc1ccc2c(Cl)nccc2c1O.O=C([O-])[O-].[K+].[K+]>>CCOc1c(OC)ccc2c(Cl)nccc12",
        "output": "198"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(Nc2ncc(Br)n3ncnc23)cc1.O.O.[Li+].[OH-]>>O=C(O)c1ccc(Nc2ncc(Br)n3ncnc23)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCO.COC(=O)C1CC(=O)N(C(C)C)C1.ClC(Cl)Cl.[Ni]>>CC(C)N1CC(CO)CC1=O",
        "output": "343"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCCC1CN.CCN(C(C)C)C(C)C.Fc1cnc(Cl)nc1Cl>>CC(C)(C)OC(=O)N1CCCC1CNc1nc(Cl)ncc1F",
        "output": "110"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)N.ClCCl.O=Cc1cc2cccc(F)c2[nH]c1=O.[Na+]>>CC(C)NCc1cc2cccc(F)c2[nH]c1=O",
        "output": "441"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.ClCCl.Nc1ccc(I)cc1.O=C([O-])O.O=Cc1ccc(OC2CCCCO2)cc1Cl.O=S(=O)([O-])[O-].[BH4-].[Mg+2].[Na+].[Na+]>>Clc1cc(OC2CCCCO2)ccc1CNc1ccc(I)cc1",
        "output": "359"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC[C@H](Nc2ncc(C#N)c3sc(-c4ccc(N5CCNCC5)cc4)cc23)C1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCC[C@H](Nc2ncc(C#N)c3sc(-c4ccc(N5CCN(S(C)(=O)=O)CC5)cc4)cc23)C1",
        "output": "584"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.CS(=O)(=O)NCCC(Sc1nnn[nH]1)C1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1.O=C(O)CS(=O)CC(F)(F)F>>CS(=O)(=O)NCCC(Sc1nnn[nH]1)C1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)CS(=O)CC(F)(F)F)[C@H]2SC1",
        "output": "133"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1CO[C@H](COc2ccc(F)cc2)CN1Cc1ccccc1.CCO.[Pd]>>CC1CO[C@H](COc2ccc(F)cc2)CN1",
        "output": "84"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(Cl)cc2c1OC(CN=[N+]=[N-])C2.COc1cc(Cl)cc2c1OC(COS(=O)(=O)c1ccc(C)cc1)C2.[N-]=[N+]=NCC1Cc2cc(Cl)cc(-c3ccsc3)c2O1.[N-]=[N+]=[N-].[N-]=[N+]=[N-].[Na+].[Pt]>>COc1cc(Cl)cc2c1OC(CN)C2",
        "output": "89"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "B.C1CCOC1.CO.C[C@@H](O)C(=O)N1CC[C@@H](NC(=O)OC(C)(C)C)C1>>C[C@@H](O)CN1CC[C@@H](NC(=O)OC(C)(C)C)C1",
        "output": "112"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOP(=O)(C#N)OCC.Cl.ClCCl.O=C(O)CCCCCc1ccccc1.[Na+].[OH-].c1cc2c(o1)CCNC2>>O=C(CCCCCc1ccccc1)N1CCc2occc2C1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO[C@H](C)C(=O)O.Cl.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1>>CO[C@H](C)C(=O)N[C@@H]1CC[C@@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(CCc1ccc(-c2ccccc2)cc1F)(C(=O)NOC1CCCCO1)S(C)(=O)=O.Cl.ClCCl>>CC(CCc1ccc(-c2ccccc2)cc1F)(C(=O)NO)S(C)(=O)=O",
        "output": "915"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCS(=O)(=O)c1cccc(-c2cnc(Cl)c3[nH]c4ncc(C)cc4c23)c1.CN(C)CCCO.[H-].[Na+]>>CCS(=O)(=O)c1cccc(-c2cnc(OCCCN(C)C)c3[nH]c4ncc(C)cc4c23)c1",
        "output": "209"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Br.Brc1cc2c(s1)CCNC2.C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCc2sc(Br)cc2C1",
        "output": "694"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=Cc1cc2ccccc2nc1I.[BH4-].[Na+]>>OCc1cc2ccccc2nc1I",
        "output": "476"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CNC.O.O=C(Cl)c1cccc(Oc2ccc(Cl)cc2[N+](=O)[O-])c1>>CN(C)C(=O)c1cccc(Oc2ccc(Cl)cc2[N+](=O)[O-])c1",
        "output": "201"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccccc1.N#CC1(c2ccccc2)CCC(=O)CC1.O.OCCO>>N#CC1(c2ccccc2)CCC2(CC1)OCCO2",
        "output": "265"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(C)=O.COc1cccc2c1ccn2-c1ccc(C#N)c(NC2CCC(O)CC2)c1.CS(C)=O.OO.[Na+].[OH-]>>COc1cccc2c1ccn2-c1ccc(C(N)=O)c(NC2CCC(O)CC2)c1",
        "output": "180"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)=C(Cl)N(C)C.ClCCl.N=C(NO)c1ccc(F)cc1.O.O=C(O)CCCCCNC(=O)COCc1ccc(F)cc1.c1ccncc1>>O=C(COCc1ccc(F)cc1)NCCCCCc1nc(-c2ccc(F)cc2)no1",
        "output": "895"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.COCCOC.N#Cc1ccccc1CBr.O=c1[nH]c(Cl)ncc1Br.[Br-].[H-].[Li+].[Na+]>>N#Cc1ccccc1Cn1c(Cl)ncc(Br)c1=O",
        "output": "389"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)c1cc(C(=O)O)cc(N2CCCC2=O)c1.C[C@H](C[C@H](O)[C@@H](N)Cc1ccccc1)C(=O)NC1CC2CCC1C2.C[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(S(C)(=O)=O)c1)C(=O)NCCC(C)(C)C>>C[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc(N2CCCC2=O)cc(S(C)(=O)=O)c1)C(=O)NC1CC2CCC1C2",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.Cc1ccc2c(Cl)nc(-c3ccccc3O)nc2c1.ClCCl.NC1CCNCC1>>Cc1ccc2c(N3CCC(N)CC3)nc(-c3ccccc3O)nc2c1",
        "output": "162"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCC[C@H](C)Oc1nc(N)c2nc(OC)n(CCCCCCl)c2n1.CCN(CC)CC.CN(C)C=O.O.O.[Cl-].[I-].[Na+].[Na+]>>CCC[C@H](C)Oc1nc(N)c2nc(OC)n(CCCCCN3CCN(C(=O)OC(C)(C)C)CC3)c2n1",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C)COc2cccc(O)c21.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)nc1.[K+].[K+]>>CC1(C)COc2cccc(Oc3ccc([N+](=O)[O-])cn3)c21",
        "output": "516"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#CCOc1ccc(S(=O)(=O)CC2(C(=O)OCC)CCNCC2)cc1.CC(C)(C)N=C=O.CCN(CC)CC.ClCCl>>CC#CCOc1ccc(S(=O)(=O)CC2(C(=O)OCC)CCN(C(=O)NC(C)(C)C)CC2)cc1",
        "output": "437"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.Cl.FC1(F)CCNCC1.N#CCBr.O.O=C([O-])[O-].[K+].[K+]>>N#CCN1CCC(F)(F)CC1",
        "output": "880"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CCOC(C)=O.CN1c2cc(B3OC(C)(C)C(C)(C)O3)ccc2N(CC2CC2(F)F)S1(=O)=O.O.O=C([O-])[O-].OCc1cccc(Br)n1.[Cs+].[Cs+].[Pd]>>CN1c2cc(-c3cccc(CO)n3)ccc2N(CC2CC2(F)F)S1(=O)=O",
        "output": "939"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.COC(=O)C1CCNCC1.ClCCCl.[Na+].[Na+].[OH-]>>COC(=O)C1CCN(C(C)C)CC1",
        "output": "187"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(CCN)cc1OC.O=C(O)CCc1cc(F)ccc1F>>COc1ccc(CCNC(=O)CCc2cc(F)ccc2F)cc1OC",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C1COCCO1.CCOC(=O)C(OC(C)(C)C)c1c(C)nc2sc3c(c2c1I)CCCC3.Cl.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccc2scnc2c1.[Cs+].[Cs+].[Fe+2].[Li+].[OH-].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1nc2sc3c(c2c(I)c1C(OC(C)(C)C)C(=O)O)CCCC3",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)O.CC(C)(C)OC(=O)N1CCC(c2ccc(N)c(OC(F)(F)F)c2)CC1.CCN(CC)CC.CCOCC.ClCCCl.FC(F)(F)c1cnc(Cl)nc1Cl.[Cl-].[Cl-].[Zn+2]>>CC(C)(C)OC(=O)N1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(Cl)n3)c(OC(F)(F)F)c2)CC1",
        "output": "808"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN[C@@H](CO)C1.[Na+]>>Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)[C@@H](CO)C1",
        "output": "217"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.CCOC(C)=O.CNC1Cc2ccc(C(=O)Cn3cnc4cc(-c5ccc(Cl)cc5)sc4c3=O)cc2C1.O>>CC(=O)N(C)C1Cc2ccc(C(=O)Cn3cnc4cc(-c5ccc(Cl)cc5)sc4c3=O)cc2C1",
        "output": "125"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOc1ccc(Nc2nc(Nc3cnn(CCCC4CCN(C(=O)OC(C)(C)C)CC4)c3)ncc2[N+](=O)[O-])cc1.CO.[Pd]>>CCOc1ccc(Nc2nc(Nc3cnn(CCCC4CCN(C(=O)OC(C)(C)C)CC4)c3)ncc2N)cc1",
        "output": "660"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COS(=O)(=O)OC.Cc1c(O)c(C)c(O)c(O)c1O.O>>COc1c(O)c(C)c(O)c(C)c1O",
        "output": "317"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCS(=O)(=O)c1cccc(Br)c1.CCc1nc2c(Cl)cccn2c1-c1cccc(O)c1>>CCc1nc2c(Cl)cccn2c1-c1cccc(Oc2cccc(S(=O)(=O)CC)c2)c1",
        "output": "238"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)NC(C)C.CN(C)C=O.Cc1ccsc1Br.[Li]CCCC>>Cc1cc(C=O)sc1Br",
        "output": "617"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.FC(F)(F)c1cnc(Cl)c(Cl)c1.O.O=CCc1ccccn1.[Zn]>>FC(F)(F)c1cncc(Cl)c1",
        "output": "40"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cn1ccc2c3nc(-c4ccc(N)cc4)nc(N4CCOCC4)c3ccc21.NC1CCS(=O)(=O)C1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cn1ccc2c3nc(-c4ccc(NC(=O)NC5CCS(=O)(=O)C5)cc4)nc(N4CCOCC4)c3ccc21",
        "output": "914"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.CN(C)C=O.COc1ccc2c(c1)SCCc1c-2n(CCCCCCl)c2ccc(OC)cc12.[I-]>>COc1ccc2c(c1)SCCc1c-2n(CCCCCN2CCCC2)c2ccc(OC)cc12",
        "output": "138"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCn1cc(-c2ccc(Cl)cc2Cl)nc1/C=C/c1ccc(-c2ccc(O)cc2)cc1.COC(=O)CCCBr>>CCn1cc(-c2ccc(Cl)cc2Cl)nc1/C=C/c1ccc(-c2ccc(OCCCC(=O)OC)cc2)cc1",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)c1cccc(CC(N)C(O)c2cccc(Cl)c2)c1.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.O.O=C(O)c1ccc(F)c2ccccc12.On1nnc2ccccc21>>CC(C)(C)c1cccc(CC(NC(=O)c2ccc(F)c3ccccc23)C(O)c2cccc(Cl)c2)c1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1cc(C#Cc2ccccc2)ccc1OC(C)C.[K+].[OH-]>>CC(C)Oc1ccc(C#Cc2ccccc2)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(CC)c1ccc(S(C)(=O)=O)cc1C(=O)O.CCOC(C)=O.Cl.c1ccc2c(N3CCNCC3)nsc2c1>>CCN(CC)c1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2nsc3ccccc23)CC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.N#CCBr.O.O=C([O-])[O-].Oc1cc(I)ccc1I.[K+].[K+]>>N#CCOc1cc(I)ccc1I",
        "output": "802"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)N1CC(C)(C)c2ccc(-n3ccc(C)c(C#Cc4cnc(N)nc4)c3=O)cc21.CC(C)(C)O.CC(C)(C)[O-].CCOC(C)=O.[Na+]>>Cc1ccn(-c2ccc3c(c2)NCC3(C)C)c(=O)c1C#Cc1cnc(N)nc1",
        "output": "504"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)OC(C)C.CCO.CS(=O)(=NC(=O)C(F)(F)F)c1ccc([N+](=O)[O-])cc1.[Pd]>>CS(=O)(=NC(=O)C(F)(F)F)c1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1.COc1cccc(OCCCCCCl)c1.Cl.Cl>>COc1cccc(OCCCCCN2CCC(CNC(=O)c3cc(Cl)c(N)cc3OC)CC2)c1",
        "output": "138"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=C1CCc2cc(N3CCN(C(=O)c4ccc([N+](=O)[O-])cc4)CC3)ccc2N1.[C].[Pd]>>Nc1ccc(C(=O)N2CCN(c3ccc4c(c3)CCC(=O)N4)CC2)cc1",
        "output": "28"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccc2ccccc2c1.CC(C)(C)OC(=O)N1CCC(c2ccc(O)cc2)C(O)C1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCC(c2ccc(OCc3ccc4ccccc4c3)cc2)C(O)C1",
        "output": "127"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)COCCCCN1CCCc2nc(-c3ccccc3)c(-c3ccccc3)nc21.ClCCl.O=C(O)C(F)(F)F>>O=C(O)COCCCCN1CCCc2nc(-c3ccccc3)c(-c3ccccc3)nc21",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCN)c1nnc(C)n1-2.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)Cc1ccc(O)c(O)c1>>COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCNC(=O)Cc1ccc(O)c(O)c1)c1nnc(C)n1-2",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)c1cccc(C(=O)OCC)n1.[BH4-].[Na+]>>CCOC(=O)c1cccc(CO)n1",
        "output": "711"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1cc(CCOC)n2cccc(C(F)(F)F)c12.Cl.ClCCl.NCC1(O)CCCC(F)(F)C1>>COCCc1cc(C(=O)NCC2(O)CCCC(F)(F)C2)c2c(C(F)(F)F)cccn12",
        "output": "498"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc(OCCCCl)ccc1C(C)=O.OC(c1ccc(F)cc1)(c1ccc(F)cc1)C1CCNCC1>>COc1cc(OCCCN2CCC(C(O)(c3ccc(F)cc3)c3ccc(F)cc3)CC2)ccc1C(C)=O",
        "output": "138"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cl.Cl.O=C(NCC(=O)N1CC2CN(Cc3ccccc3)CC21)c1cccc(C(F)(F)F)c1.[Pd]>>O=C(NCC(=O)N1CC2CNCC21)c1cccc(C(F)(F)F)c1",
        "output": "84"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCC(CC)CC(C(=O)OC)n1ncc(OCC2CCCC2)c(Cl)c1=O.CO.[Na+].[OH-]>>CCCC(CC)CC(C(=O)O)n1ncc(OCC2CCCC2)c(Cl)c1=O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCCn1cc(C(=O)OCC)c(=O)n(-c2cccc(C(F)(F)F)c2)c1=O.O.[Na+].[OH-]>>CCCCn1cc(C(=O)O)c(=O)n(-c2cccc(C(F)(F)F)c2)c1=O",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC2(CCNCC2)CC1.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.CS(=O)(=O)c1ccc(Br)cn1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]>>CC(C)(C)OC(=O)N1CCC2(CC1)CCN(c1ccc(S(C)(=O)=O)nc1)CC2",
        "output": "597"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCCC(CNc2cc(Nc3cnc(C#N)cn3)ncc2-n2ccc(C(=O)O)c2)C1.CO>>N#Cc1cnc(Nc2cc(NCC3CCCNC3)c(-n3ccc(C(=O)O)c3)cn2)cn1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)Cl.COC1(c2ccc(C(F)(F)F)cc2CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)CCNCC1.ClCCl>>CCOC(=O)N1CCC(OC)(c2ccc(C(F)(F)F)cc2CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)CC1",
        "output": "219"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)CCc1cc(OC(C)C)nn1Cc1ccc(C(F)(F)F)cc1C.CO.Cc1ccccc1.O=C([O-])[C@H](O)[C@@H](O)C(=O)[O-].[H-].[K+].[Na+]>>Cc1cc(C(F)(F)F)ccc1Cn1nc(OC(C)C)cc1CCCO",
        "output": "225"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#Cc1cccc(N)c1.CCN(CC)CC.ClCCl.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>C#Cc1cccc(NC(=O)C(F)(F)F)c1",
        "output": "106"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1nc(N)ccc1C#N.Cl.Cl[Co]Cl.O.O.O.O.O.O.[BH4-].[Na+]>>Cc1nc(N)ccc1CN",
        "output": "560"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cn1c(N2CCCNCC2)nc2ccccc21.O=C(NCC(F)(F)F)C1(CCCCBr)c2ccccc2Oc2ccccc21>>Cn1c(N2CCCN(CCCCC3(C(=O)NCC(F)(F)F)c4ccccc4Oc4ccccc43)CC2)nc2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CNc1ncnc2cc(OC)c([N+](=O)[O-])cc12.CO>>CNc1ncnc2cc(OC)c(N)cc12",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.COc1cc(C(C)=O)ccc1OCCCl.Clc1ccc2c(C3CCNCC3)noc2c1.O=C([O-])[O-].[K+].[K+]>>COc1cc(C(C)=O)ccc1OCCN1CCC(c2noc3cc(Cl)ccc23)CC1",
        "output": "138"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)CCCCCCCC=Cc1ccc(F)cc1>>O=C(Cl)CCCCCCCC=Cc1ccc(F)cc1",
        "output": "56"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)c1ccc(N)c(C)c1F.Cl.[Na+].[OH-]>>Cc1c(N)ccc(C(=O)O)c1F",
        "output": "5"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)NC(=O)c1cccc(Oc2ccc(Nc3ncnc4c3C=C(C(=O)O)CCN4)cc2Cl)c1.CC(C)(N)CO.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.On1nnc2ccccc21>>CC(C)(C)NC(=O)c1cccc(Oc2ccc(Nc3ncnc4c3C=C(C(=O)NC(C)(C)CO)CCN4)cc2Cl)c1",
        "output": "549"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COCOc1cccc(N)c1>>COCOc1cccc(NC(=O)OC(C)(C)C)c1",
        "output": "735"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.FC(F)(F)c1nnc2ccc(Cl)nn12.O.OC1(c2cccnc2)CCNCC1>>OC1(c2cccnc2)CCN(c2ccc3nnc(C(F)(F)F)n3n2)CC1",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.C[C@H](OCc1ccccc1)[C@@H](O)CCc1cccc2ccccc12.ClCCl>>C[C@H](OCc1ccccc1)[C@H](CCc1cccc2ccccc12)OS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrBr.ClCCl.O.c1ccc2c(c1)ccc1c2[nH]c2ccc3ccccc3c21>>Brc1cc2c([nH]c3ccc4ccccc4c32)c2ccccc12",
        "output": "98"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCCCCCOc1ccc(C(=O)O)cc1C(F)(F)F.NN.NNC(=O)c1ccccc1.O.O=C(n1ccnc1)n1ccnc1>>CCCCCCCCOc1ccc(C(=O)NN)cc1C(F)(F)F",
        "output": "55"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)[O-].CC(C)O.Clc1ncnc2ccc(Br)cc12.[K+]>>CC(C)Oc1ncnc2ccc(Br)cc12",
        "output": "461"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCOC(=O)C(C)C1CCOCC1.Cl.O.[Na+].[OH-]>>CC(C(=O)O)C1CCOCC1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.CCOC(=O)Cn1c2c(c3cc(Cl)ccc31)CN(C)CC2>>CN1CCc2c(c3cc(Cl)ccc3n2CC(=O)N2CCOCC2)C1",
        "output": "494"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Nc1cccc(C(=O)O)c1Br.O=S(=O)(O)O>>COC(=O)c1cccc(N)c1Br",
        "output": "33"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOc1c(-c2cnc3ccc(C=CC(=O)OC)cn23)cc(C(C)C)cc1C(C)C.CO.[Cl-].[NH4+].[Na+].[OH-]>>CCOc1c(-c2cnc3ccc(C=CC(=O)O)cn23)cc(C(C)C)cc1C(C)C",
        "output": "58"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C)=O.COCOc1ccc(C2(C)COc3cc(OCOC)ccc3C2c2cccc(OCCCCCl)c2)cc1.O.[I-].[Na+]>>COCOc1ccc(C2(C)COc3cc(OCOC)ccc3C2c2cccc(OCCCCI)c2)cc1",
        "output": "97"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClC(Cl)Cl.Nc1ccc(Br)cc1.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)Nc1ccc(Br)cc1",
        "output": "735"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.OCCCCCCCCCCCc1ccccc1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCCCCCCCCCCCc2ccccc2)cc1",
        "output": "197"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)Nc1nc2ccc(C)cc2nc1OC.c1ccc(N2CCNCC2)nc1>>COc1nc2cc(C)ccc2nc1NC(=O)N1CCN(c2ccccn2)CC1",
        "output": "613"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCN1.O=Cc1cccc(C#CCCN2CCOCC2)c1>>C(#Cc1cccc(CN2CCOCC2)c1)CCN1CCOCC1",
        "output": "567"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cl.N#Cc1ccc(CCC(=O)N2CCCc3ccccc32)cc1.O=S(=O)(O)Cl>>N#Cc1ccc(CCC(=O)N2CCCc3cc(S(=O)(=O)Cl)ccc32)cc1",
        "output": "182"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=S(=O)(CCCO)c1cccc(Br)c1.Oc1ccc(Cl)c(-c2ncnc3c(C(F)(F)F)cccc23)c1>>O=S(=O)(CCCO)c1cccc(Oc2ccc(Cl)c(-c3ncnc4c(C(F)(F)F)cccc34)c2)c1",
        "output": "238"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.Nc1cc(C(F)(F)F)ccc1[N+](=O)[O-].O.O=C1CCC(=O)N1Br>>Nc1cc(C(F)(F)F)c(Br)cc1[N+](=O)[O-]",
        "output": "4"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1=NCCCN2CCCCC12.CC#N.COc1cc(OC)nc(NC(=O)Oc2ccccc2)n1.Cl.NS(=O)(=O)c1ccccc1S(=O)(=O)NC1CC1.O>>COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2ccccc2S(=O)(=O)NC2CC2)n1",
        "output": "690"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.ClCCl.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].O=S(=O)(Oc1ccc2cc(O)ccc2c1)C(F)(F)F.OB(O)c1cccc2ccccc12.[K+].[K+].[K+].[Pd].[Pd].c1ccc(-c2ccccc2P(C2CCCCC2)C2CCCCC2)cc1>>Oc1ccc2cc(-c3cccc4ccccc34)ccc2c1",
        "output": "825"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)n1ncnc1-c1cn2c(n1)-c1cnc(O[C@@H](C)C(=O)OC(C)(C)C)cc1OCC2.Cl>>CC(C)n1ncnc1-c1cn2c(n1)-c1cnc(O[C@@H](C)C(=O)O)cc1OCC2",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(C(C)C)C(C)C.Cc1n[nH]c2c1c(=O)n(CCN)c1ccccc21.O=Cc1ccccc1.[Na+]>>Cc1n[nH]c2c1c(=O)n(CCNCc1ccccc1)c1ccccc21",
        "output": "468"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)Cn1cc(-c2ccc(F)c(C)c2)nc1-c1ccc(F)cc1.[Na+].[OH-]>>Cc1cc(-c2cn(CC(=O)O)c(-c3ccc(F)cc3)n2)ccc1F",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.COc1cccc(C(O)c2cc(Cl)cnc2NC(=O)OC(C)(C)C)c1OC.Cl.O.[Na+].[OH-]>>COc1cccc(C(O)c2cc(Cl)cnc2N)c1OC",
        "output": "885"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CCN(C(C)C)C(C)C.COc1cc2ncnc(Oc3ccc4[nH]ccc4c3F)c2cc1OCC1CCNCC1.ClCCl>>COc1cc2ncnc(Oc3ccc4[nH]ccc4c3F)c2cc1OCC1CCN(C(C)=O)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1nc(CC)n(-c2ccc(OC(C)C)c(F)c2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1nc(CC)n(-c2ccc(OC(C)C)c(F)c2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)C(c1ccccc1)C(c1ccccc1)c1ccc2c(cnn2-c2ccc(F)cc2)c1.CS(C)=O.Cl.[Na+].[OH-]>>O=C(O)C(c1ccccc1)C(c1ccccc1)c1ccc2c(cnn2-c2ccc(F)cc2)c1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)C=O.ClCCl.Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1.O=C(Cl)C(=O)Cl.O=C(O)c1cccnc1Cl.O=C([O-])O.[Na+]>>O=C1CC(=O)N(c2ccc(NC(=O)c3cccnc3Cl)cc2)c2ccc3ccccc3c2N1",
        "output": "739"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cc(Cl)nc(-c2cnc(C(F)(F)F)nc2)c1.Cl>>O=C(NCc1cc(Cl)nc(-c2cnc(C(F)(F)F)nc2)c1)[C@@H]1C[C@@H](F)CN1",
        "output": "634"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cc(C)c(-c2nc3c([nH]2)CN(C(=O)OC(C)(C)C)CC3)cc1C(=O)N1CCC(c2ccc(C#N)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(C)c(-c2nc3c([nH]2)CNCC3)cc1C(=O)N1CCC(c2ccc(C#N)cc2)CC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.COc1cc(Cl)ccc1-c1nccc2cc(S(=O)(=O)Nc3ccncn3)ccc12.Cc1ccccc1B(O)O.O.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>COc1cc(-c2ccccc2C)ccc1-c1nccc2cc(S(=O)(=O)Nc3ccncn3)ccc12",
        "output": "892"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCN(C2(CN)CCCCC2)CC1.O.O=C(Cl)c1ccc(Cl)c(Cl)c1.c1ccccc1>>CN1CCN(C2(CNC(=O)c3ccc(Cl)c(Cl)c3)CCCCC2)CC1",
        "output": "271"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.Nc1nc(-c2ccccc2O)cc(C2CCCN(C(=O)OCc3ccccc3)C2)c1C(=O)O>>COC(=O)c1c(C2CCCN(C(=O)OCc3ccccc3)C2)cc(-c2ccccc2O)nc1N",
        "output": "195"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc(CCCC2CCN(C[C@H]3CN([C@@H](C(=O)O)C4CCCCC4)C[C@@H]3c3ccccc3)CC2)cc1.[Na+].[OH-]>>O=C(O)c1ccc(CCCC2CCN(C[C@H]3CN([C@@H](C(=O)O)C4CCCCC4)C[C@@H]3c3ccccc3)CC2)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.Nc1ccc([N+](=O)[O-])c(NCc2ccccc2)c1.O>>CC(C)(C)OC(=O)Nc1ccc([N+](=O)[O-])c(NCc2ccccc2)c1",
        "output": "735"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.CO.COc1c(Cl)cc[n+]([O-])c1C.C[O-].ClCCl.O=S(=O)(O)O.[Na+]>>COc1cc[n+]([O-])c(C)c1OC",
        "output": "651"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1.CC(C)COC(=O)Cl.CN1CCOCC1.O.O=C(O)Cc1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)Cc3csc(NC(c4ccccc4)(c4ccccc4)c4ccccc4)n3)[C@H]2SC1",
        "output": "133"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(C(C)Oc2cc(C)c(-c3ccc(C(F)(F)F)cc3)c(C)c2)s1.Cl.[Li+].[OH-]>>Cc1cc(OC(C)c2ccc(C(=O)O)s2)cc(C)c1-c1ccc(C(F)(F)F)cc1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.ClCCl.O=C(O)[C@@H]1CCCN1C(=O)CCCc1ccccc1>>O=C([C@@H]1CCCN1C(=O)CCCc1ccccc1)N1CCCC1",
        "output": "685"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1nn(C)c2c1CCc1cnc(N)nc1-2.[Na+].[OH-]>>Cn1nc(C(=O)O)c2c1-c1nc(N)ncc1CC2",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1nnc2ccc(Cl)nn12.CN(C)C=O.Cc1onc(-c2ccccc2)c1CO.[H-].[Na+]>>CCOC(=O)c1nnc2ccc(OCc3c(-c4ccccc4)noc3C)nn12",
        "output": "407"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.ClCCl.Cl[Pd]Cl.O.O=C([O-])[O-].O=C(c1ccc2ncccc2c1)c1cnc2ccc(Cl)nn12.OB(O)c1ccccc1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=C(c1ccc2ncccc2c1)c1cnc2ccc(-c3ccccc3)nn12",
        "output": "866"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CN1CCNCC1.Clc1ccc2nc(Cl)c3cccn3c2c1.O>>CN1CCN(c2nc3ccc(Cl)cc3n3cccc23)CC1",
        "output": "505"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.O.O=[N+]([O-])c1cc2c(Nc3cccc(Br)c3)ncnc2cc1F.OCCCN1CCOCC1.[Na]>>O=[N+]([O-])c1cc2c(Nc3cccc(Br)c3)ncnc2cc1OCCCN1CCOCC1",
        "output": "636"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cc2nc(N)cc(-c3ccccc3)n2n1.O=C(Cl)c1ccc(SC(F)(F)F)cc1.c1ccncc1>>Cc1cc2nc(NC(=O)c3ccc(SC(F)(F)F)cc3)cc(-c3ccccc3)n2n1",
        "output": "463"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.O=[Mn]=O.OCC=Cc1ccc(-n2cccn2)nc1>>O=CC=Cc1ccc(-n2cccn2)nc1",
        "output": "183"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1CNCCN1.O.O=[N+]([O-])c1ccc(F)cc1>>CC1CN(c2ccc([N+](=O)[O-])cc2)CCN1",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=C(C)n1c(=O)n(CCCCl)c2ccc(C)cc21.CC(=O)CC(C)C.O.O=C([O-])[O-].O=c1[nH]c2ccccc2n1C1CCNCC1.[Na+].[Na+]>>C=C(C)n1c(=O)n(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)c2ccc(C)cc21",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.CCc1nc(CC(C)(C)C)c(CNC(=O)OC(C)(C)C)c(-c2ccc(C)cc2)c1CO.CS(=O)(=O)Cl>>CCc1nc(CC(C)(C)C)c(CNC(=O)OC(C)(C)C)c(-c2ccc(C)cc2)c1COS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCc1ccccc1.CC#N.CCC(=O)N(c1ccccc1)C1(c2nnc(CC)o2)CCNCC1.O=C([O-])[O-].[I-].[Na+].[Na+].[Na+]>>CCC(=O)N(c1ccccc1)C1(c2nnc(CC)o2)CCN(CCc2ccccc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "N#Cc1ccc(-c2cnn(-c3ccc(C(=O)O)cn3)c2O)cc1.NCCCn1cccn1>>N#Cc1ccc(-c2cnn(-c3ccc(C(=O)NCCCn4cccn4)cn3)c2O)cc1",
        "output": "674"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)CCCCCSc1ccc(-c2ccc(Cl)cc2)cc1.NO.[K+].[OH-]>>O=C(O)CCCCCSc1ccc(-c2ccc(Cl)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.Oc1ccc([C@@H]2CC[C@@H](NCCCc3ccccc3)CC2)cc1>>CC(=O)N(CCCc1ccccc1)[C@@H]1CC[C@@H](c2ccc(O)cc2)CC1",
        "output": "369"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.C=CC1=C(c2ccc(OC)cc2)CCCc2cc(OC)ccc21.ClCCl.O>>C=CC1=C(c2ccc(O)cc2)CCCc2cc(O)ccc21",
        "output": "20"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(NC(=O)C1CC(=O)C2c3c(ccn3C1)CCC2NC(=O)C(C)N(C)C(=O)OC(C)(C)C)c1ccccc1.CCOC(C)=O.CO.Cl>>CNC(C)C(=O)NC1CCc2ccn3c2C1C(=O)CC(C(=O)NC(C)c1ccccc1)C3",
        "output": "634"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cl.O=C(O)c1ccc(F)cc1C(F)(F)F.OCc1ccccc1.[H-].[Na+]>>O=C(O)c1ccc(OCc2ccccc2)cc1C(F)(F)F",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1c(-c2ccccn2)nc2c(Cl)cccc2c1Cl.Cc1ccccc1.Nc1cc(N2CCOCC2)cnc1N1CCOCC1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1c(-c2ccccn2)nc2c(Cl)cccc2c1Nc1cc(N2CCOCC2)cnc1N1CCOCC1",
        "output": "859"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1scc(Br)c1-c1ncn[nH]1.O=C(O)Cn1c(=O)ccc2cnc(C(F)(F)F)cc21>>O=C(Cn1c(=O)ccc2cnc(C(F)(F)F)cc21)Nc1scc(Br)c1-c1ncn[nH]1",
        "output": "882"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1ccc2c(c1C)SCCC2NC(=O)OC(C)(C)C.O=C([O-])[O-].[K+].[K+]>>Cc1c(C(=O)O)ccc2c1SCCC2NC(=O)OC(C)(C)C",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.COC(=O)[C@@H]1CC[C@@H](N)CC1.Cl.Cl.ClC(Cl)Cl.O=S(=O)(Cl)CCCCl>>COC(=O)[C@@H]1CC[C@@H](NS(=O)(=O)CCCCl)CC1",
        "output": "493"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.CC(C)c1nc2c(c(-c3ccc(F)cc3)c1C(OC(C)(C)C)C(=O)O)CNCC2(C)C.CCN(CC)CC.ClCCl>>CC(=O)N1Cc2c(nc(C(C)C)c(C(OC(C)(C)C)C(=O)O)c2-c2ccc(F)cc2)C(C)(C)C1",
        "output": "369"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1CN(C(=O)c2ccccc2)CCN1.CCN(CC)CC.CO.ClC(Cl)Cl.ClCCl.O=S(=O)(Cl)c1cccc(Br)c1>>CC1CN(C(=O)c2ccccc2)CCN1S(=O)(=O)c1cccc(Br)c1",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NCCCN1CCC(c2cccc(NC(=O)C3CC3)c2)CC1.O=C(O)CC(c1ccccc1)c1ccccc1>>O=C(CC(c1ccccc1)c1ccccc1)NCCCN1CCC(c2cccc(NC(=O)C3CC3)c2)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)c1cc(NC(=O)OC(C)(C)C)c([N+](=O)[O-])cc1-c1cccc(F)c1F.Cl[Sn]Cl.O.O>>CN(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1-c1cccc(F)c1F",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)N1CCC(S)CC1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCN(C(C)C)C(C)C.Cc1nc(-c2cn3c(n2)-c2cc(Br)ccc2OCC3)n(C(C)C)n1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]>>Cc1nc(-c2cn3c(n2)-c2cc(SC4CCN(C(C)C)CC4)ccc2OCC3)n(C(C)C)n1",
        "output": "824"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(C)=O.CS(=O)(=O)c1ccc(C(CC2CCC3(C2)OCCO3)c2cc3cccnc3[nH]2)cc1.Cl>>CS(=O)(=O)c1ccc(C(CC2CCC(=O)C2)c2cc3cccnc3[nH]2)cc1",
        "output": "251"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.ClCCl.Clc1ccc(-c2csc(COCc3ccccc3)n2)cc1.O=C([O-])O.[Na+]>>OCc1nc(-c2ccc(Cl)cc2)cs1",
        "output": "178"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)c1c(N)nn2cccnc12.CO.O=C(Cl)COC1CCCC1.c1ccncc1>>CC(C)c1c(NC(=O)COC2CCCC2)nn2cccnc12",
        "output": "527"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCn1c(Cl)nc2nc(C3CCCC3)[nH]c2c1=O.CCOC(C)=O.CN1CCCC1=O.O.O=C([O-])[O-].Oc1ccc(F)c(F)c1.[K+].[K+]>>CCCn1c(Oc2ccc(F)c(F)c2)nc2nc(C3CCCC3)[nH]c2c1=O",
        "output": "542"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc(Br)cc1Cl.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>Clc1cc(Br)ccc1CBr",
        "output": "29"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)[C@H](Cc1ccc(CCCC(C)O)s1)NC(=O)OC(C)(C)C.ClCCl.O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1>>COC(=O)[C@H](Cc1ccc(CCCC(C)=O)s1)NC(=O)OC(C)(C)C",
        "output": "87"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccc(C(=O)O)cc1.Cl.FC(F)(F)c1ccc(C2NCCc3sccc32)cc1.O.On1nnc2ccccc21>>CN(C)c1ccc(C(=O)N2CCc3sccc3C2c2ccc(C(F)(F)F)cc2)cc1",
        "output": "794"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)c1c(Nc2cc(Cl)ccc2[N+](=O)[O-])sc2ccccc12.Cl.Cl[Sn]Cl.O.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1c(Nc2cc(Cl)ccc2N)sc2ccccc12",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)c1ccncc1.ClCCl.Nc1ccc(F)c2cccnc12.O=[N+]([O-])c1cc(C(F)(F)F)ccc1S(=O)(=O)Cl.c1ccncc1>>O=[N+]([O-])c1cc(C(F)(F)F)ccc1S(=O)(=O)Nc1ccc(F)c2cccnc12",
        "output": "554"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(C)=O.Cl.Fc1ccc(OC[C@@H]2CC[C@H]3CNCCN3C2)cc1.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[Na+].[Na+]>>O=[N+]([O-])c1ccc(N2CCN3C[C@H](COc4ccc(F)cc4)CC[C@H]3C2)cc1",
        "output": "26"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.CCc1[nH]c(C(=O)O)nc1Cl.CCc1nc(N2CC(N)C2)sc1C(=O)OC.CN1CCOCC1.Cl.On1nnc2ccccc21>>CCc1nc(N2CC(NC(=O)c3nc(Cl)c(CC)[nH]3)C2)sc1C(=O)OC",
        "output": "951"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.COc1ncc(-c2ccc3c(c2)c(C(C)=O)cn3CC(=O)OC(C)(C)C)cn1.Cl>>COc1ncc(-c2ccc3c(c2)c(C(C)=O)cn3CC(=O)O)cn1",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCCS(=O)(=O)c1cc(-c2cn(CC(=O)OC)cc2C#N)cc(C(F)(F)F)c1.Cl.ClCCl.O.[Li+].[OH-]>>CCCCS(=O)(=O)c1cc(-c2cn(CC(=O)O)cc2C#N)cc(C(F)(F)F)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNC1.CC#N.Cc1cccc(-c2nc3ccccn3c2-c2ccnc(S(C)(=O)=O)n2)n1>>Cc1cccc(-c2nc3ccccn3c2-c2ccnc(N3CCCC3)n2)n1",
        "output": "679"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCc2ccc(NS(C)(=O)=O)cc2CC1.O=C([O-])O.O=CO.[Na+]>>CS(=O)(=O)Nc1ccc2c(c1)CCNCC2",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)CC(C)C.CC1CC(n2c(=O)[nH]c3cc(Cl)ccc32)CCN1.Fc1ccc(C(CCCCl)c2ccc(F)cc2)cc1.O.O=C([O-])[O-].[I-].[K+].[Na+].[Na+]>>CC1CC(n2c(=O)[nH]c3cc(Cl)ccc32)CCN1CCCC(c1ccc(F)cc1)c1ccc(F)cc1",
        "output": "138"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCN1.CC(C)=O.COc1cccc(S(=O)(=O)Cl)c1>>COc1cccc(S(=O)(=O)N2CCOCC2)c1",
        "output": "99"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(c1cc(NC(=O)Oc2ccccc2)no1)C(F)(F)F.CN(C)C=O.COc1cc2ncnc(Oc3cccc(N)c3)c2cc1O>>COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)c2cc1O",
        "output": "948"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1ccccc1.CCOB(OCC)OCC.CN(C)C=O.Oc1ccc(O)c(O)c1.[H-].[Na+]>>Oc1ccc(OCc2ccccc2)cc1O",
        "output": "127"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCc1cc(C=CNC(=O)OC)ccc1OCC1CO1.CC(C)N.CC(C)O>>C=CCc1cc(C=CNC(=O)OC)ccc1OCC(O)CNC(C)C",
        "output": "16"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CN(C)C=O.COCCOC.C[C@H]1COCCN1c1cc(C(C)(C)O)nc(Cl)n1.Cl.Cn1cc(CNC(=O)Nc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)cn1.O.O=C([O-])[O-].[Na+].[Na+]>>C[C@H]1COCCN1c1cc(C(C)(C)O)nc(-c2ccc(NC(=O)NCc3cnn(C)c3)cc2)n1",
        "output": "974"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc2c(C)n[nH]c(=O)c2c1.O=P(Cl)(Cl)Cl>>COc1ccc2c(C)nnc(Cl)c2c1",
        "output": "537"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCc1cc(Br)ccc1N.COc1ccc(Cn2cc(B3OC(C)(C)C(C)(C)O3)cn2)cc1.Cl[Pd]Cl.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCc1cc(-c2cnn(Cc3ccc(OC)cc3)c2)ccc1N",
        "output": "971"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)c1ccc(CNC(=O)c2cc([N+](=O)[O-])ccc2NC2CCCC2)cc1.Cl.[Na+].[OH-]>>O=C(O)c1ccc(CNC(=O)c2cc([N+](=O)[O-])ccc2NC2CCCC2)cc1",
        "output": "5"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)OCc1c(-c2cc(Nc3cnccn3)c(=O)n(C)c2)ccnc1-n1ncc2cc(C(C)(C)C)cc(F)c2c1=O.CC(C)O.O.O.[Li+].[OH-]>>Cn1cc(-c2ccnc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(Nc2cnccn2)c1=O",
        "output": "348"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCC.CCI.CCOC(C)=O.CN(C)C=O.O=Cc1c[nH]c2ccccc12.[H-].[Na+]>>CCn1cc(C=O)c2ccccc21",
        "output": "302"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCCC[C@H]1CNc1ncnc2ccccc12.O=C(O)C(F)(F)F>>c1ccc2c(NC[C@@H]3CCCCN3)ncnc2c1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCOCCCCCCCCCCN.CN(C)C=O.Cc1ccc(OCCCCCCCCBr)cc1.[N-]=[N+]=[N-].[Na+]>>Cc1ccc(OCCCCCCCCN=[N+]=[N-])cc1",
        "output": "622"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOCn1ccc2c(C(=O)O)cccc21.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.NC1CC1>>CCOCn1ccc2c(C(=O)NC3CC3)cccc21",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CCN(CC)CC.COc1cccc(CNc2nccc(-c3cc(N4CCN(CCCO)CC4)c4cc(OC)ccc4c3)n2)c1.CS(=O)(=O)Cl.ClCCl.O>>COc1cccc(CNc2nccc(-c3cc(N4CCN(CCCN5CCCCC5)CC4)c4cc(OC)ccc4c3)n2)c1",
        "output": "371"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.CON.Cl.Cl.O.O=C([O-])[O-].O=C1CCNCC1.[K+].[K+]>>CON=C1CCNCC1",
        "output": "86"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCC1OC2(CCNCC2)c2c(Cl)cccc21.CCN(C(C)C)C(C)C.ClCCl.O=C=NC1C2CC3CC(C2)CC1C3>>C=CCC1OC2(CCN(C(=O)NC3C4CC5CC(C4)CC3C5)CC2)c2c(Cl)cccc21",
        "output": "437"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1cnc(OCC2CCC2)cn1.CO.[Na+].[OH-]>>O=C(O)c1cnc(OCC2CCC2)cn1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)c1cccc(OCC=C(c2ccccc2)c2cccnc2)c1.Cl.O.[Na+].[OH-]>>O=C(O)c1cccc(OCC=C(c2ccccc2)c2cccnc2)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(=O)C1CCN(c2cccc(Br)c2)CC1.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)C1CCN(c2cccc(B3OC(C)(C)C(C)(C)O3)c2)CC1",
        "output": "942"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)[C@@H]1CCCN1C1CCN(C(=O)[C@@H](Cc2cc(C)c3[nH]c(=O)oc3c2)OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)CC1.O.[Li+].[OH-]>>Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCC[C@H]3C(=O)O)CC2)cc2oc(=O)[nH]c12",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)C(=O)Cl.CCN(CC)CC.CCOCc1nc2c(N)nc3cccnc3c2n1CC(C)(C)N.ClCCl>>CCOCc1nc2c(N)nc3cccnc3c2n1CC(C)(C)NC(=O)C(C)C",
        "output": "45"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)c1ccc(C(=O)Cl)cc1.CCOC(C)=O.COc1ccc(C(=O)Nc2ncccc2N)cc1.C[Si](C)(C)[N-][Si](C)(C)C.[Cl-].[K+].[NH4+]>>COc1ccc(C(=O)Nc2ncccc2NC(=O)c2ccc(C(C)(C)C)cc2)cc1",
        "output": "501"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CNCc1cn(S(=O)(=O)c2cccc(F)c2)c2cc(Br)cnc12.ClCCl.O>>CN(Cc1cn(S(=O)(=O)c2cccc(F)c2)c2cc(Br)cnc12)C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)COc1ccc([N+](=O)[O-])cc1.[Pd]>>COC(=O)COc1ccc(N)cc1",
        "output": "202"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)COC(=O)Cl.CN1CCOCC1.C[C@H](NC(=O)OC(C)(C)C)C(=O)O.ClCCl.Nc1ncccc1Nc1ccccn1.[Cl-].[NH4+]>>C[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1ncccc1Nc1ccccn1",
        "output": "368"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "N#Cc1ccc(-c2ccn(CCN)n2)cc1[N+](=O)[O-].O=C(O)c1cc(-c2ccccn2)n[nH]1>>N#Cc1ccc(-c2ccn(CCNC(=O)c3cc(-c4ccccn4)n[nH]3)n2)cc1[N+](=O)[O-]",
        "output": "816"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(C)=O.COC(=O)c1ccc(-c2cc(F)ccc2C=O)cn1.ClCCCl.Nc1ccc(Br)c(F)c1.[Na+]>>COC(=O)c1ccc(-c2cc(F)ccc2CNc2ccc(Br)c(F)c2)cn1",
        "output": "359"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C(=O)N1CC1.COc1cccc(F)c1C#N.[Na+].c1cn[n-]c1>>COc1cccc(-n2cccn2)c1C#N",
        "output": "751"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(OC)c2c(Oc3cnn(CC(=O)O)c3)ncnc2c1.Nc1cccc2c1OCO2>>COc1cc(OC)c2c(Oc3cnn(CC(=O)Nc4cccc5c4OCO5)c3)ncnc2c1",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CNC(=O)c1cc(C(=O)O)c(C)cc1C1CCC1.Cc1nnc(-c2cc(C(=O)O)c(C)cc2C2CCC2)[nH]1.Cl.N#Cc1ccc(C2(F)CNC2)cc1.c1cc2[nH]ncc2cc1C1CCNCC1>>Cc1nnc(-c2cc(C(=O)N3CC(F)(c4ccc(C#N)cc4)C3)c(C)cc2C2CCC2)[nH]1",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)NC1CCN(c2ccc(CO)cc2)CC1.CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-]>>CC(=O)NC1CCN(c2ccc(C=O)cc2)CC1",
        "output": "179"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)Nc1ccc(Cl)nc1N(C)C1CCN(Cc2ccccc2)CC1.CC(Cl)OC(=O)Cl.CO.Cc1ccccc1.ClCCl>>CC(C)Nc1ccc(Cl)nc1N(C)C1CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCN1.Cn1ncc(C(=O)O)c1C(=O)Nc1ccn2nc(-c3ccnc(F)c3)nc2c1>>Cn1ncc(C(=O)N2CCOCC2)c1C(=O)Nc1ccn2nc(-c3ccnc(F)c3)nc2c1",
        "output": "733"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)C1CNC1.Cl.Cl.F[P-](F)(F)(F)(F)F.O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)OCc1ccccc1>>COC(=O)C1CN(C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)OCc2ccccc2)C1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCC(CCOc1ccc(OCC(=O)OCC)c(C)c1)c1sc2cc(C(F)(F)F)ccc2c1C.CO.[Na+].[OH-]>>CCCCC(CCOc1ccc(OCC(=O)O)c(C)c1)c1sc2cc(C(F)(F)F)ccc2c1C",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CCOC(=O)C(C)Oc1ccc(Cl)c(C)c1Cl.Cl>>Cc1c(Cl)ccc(OC(C)C(=O)O)c1Cl",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCC(=O)Cl.Nc1ccc2ncnc(Nc3cccc(Cl)c3)c2c1>>COCC(=O)Nc1ccc2ncnc(Nc3cccc(Cl)c3)c2c1",
        "output": "9"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)N.CCN(CC)CC.CN(C)C=O.O=C(O)c1cccc(-n2ccc3cc([N+](=O)[O-])ccc32)c1.O=S(Cl)Cl>>CC(C)(C)NC(=O)c1cccc(-n2ccc3cc([N+](=O)[O-])ccc32)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCc1cc(C(=O)OCC)c(C)o1.CCO.[Na+].[OH-]>>CCCCCc1cc(C(=O)O)c(C)o1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC1(C)OB(c2cn[nH]c2)OC1(C)C.CCI.O=C([O-])[O-].[Cs+].[Cs+]>>CCn1cc(B2OC(C)(C)C(C)(C)O2)cn1",
        "output": "346"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.CCN(CC)CC.CN1CCCCCC1Cc1ccc(N)cc1.c1ccccc1>>CC(=O)Nc1ccc(CC2CCCCCN2C)cc1",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CC[C@H](NC(=O)OC(C)(C)C)c1cc(-c2c([N+](=O)[O-])cnn2C(F)F)ccn1.CO.O.[Cl-].[Fe].[NH4+]>>C=CC[C@H](NC(=O)OC(C)(C)C)c1cc(-c2c(N)cnn2C(F)F)ccn1",
        "output": "628"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc2cc(Oc3c(Br)cc([N+](=O)[O-])cc3Br)ccc2n1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>O=[N+]([O-])c1cc(Br)c(Oc2ccc3nc(CBr)ccc3c2)c(Br)c1",
        "output": "590"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1nc2cccc(Cl)c2c(=O)n1N1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CNOC.Cl.Cl.O=C(O)c1cc(Cl)nc(Cl)c1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CON(C)C(=O)c1cc(Cl)nc(Cl)c1",
        "output": "828"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)C(=O)Cl.CC(C)(C)OC(=O)NC1CNc2ccccc2NC1=O.ClCCCl.c1ccncc1>>CC(C)(C)OC(=O)NC1CN(C(=O)C(C)(C)C)c2ccccc2NC1=O",
        "output": "160"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)C1CCC(=O)CC1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.C[Si](C)(C)[N-][Si](C)(C)C.[Br-].[Li+]>>C=C1CCC(C(=O)OCC)CC1",
        "output": "601"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrP(Br)Br.C1CCOC1.ClCCl.O.OCc1cc(I)cc(I)c1I>>BrCc1cc(I)cc(I)c1I",
        "output": "300"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCc2ccc(O)cc2C1.CN(C)c1ccncc1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N[C@H]1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1",
        "output": "731"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1Cl.O.[K+].[OH-]>>CC(C)(Oc1ccc(Cl)cc1Cl)C(=O)O",
        "output": "192"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCc1cccc2cnccc12>>ClCc1cccc2cnccc12",
        "output": "713"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O=[Pt].OCCCCCC=Cc1ccc(Cl)cc1Cl>>OCCCCCCCc1ccc(Cl)cc1Cl",
        "output": "362"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Br.CC(=O)O.COc1ccc(C(=O)C2CCNCC2)cc1.Cl.O=C([O-])O.[Na+]>>O=C(c1ccc(O)cc1)C1CCNCC1",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)c1ccc(O)cc1.CCO.COS(=O)(=O)OC.O.[Na+].[OH-]>>COc1ccc(C(C)=O)cc1",
        "output": "317"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CCOC(C)=O.COC(=O)C1(c2ccc(C(F)(F)F)c([N+](=O)[O-])c2)CC1.[Fe]>>COC(=O)C1(c2ccc(C(F)(F)F)c(N)c2)CC1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CSc1ccc(-c2ccc(OCC3CCN(c4nc(C(C)C)no4)CC3)cn2)cc1.ClCCl.OC(C(F)(F)F)C(F)(F)F.OO>>CC(C)c1noc(N2CCC(COc3ccc(-c4ccc(S(C)=O)cc4)nc3)CC2)n1",
        "output": "199"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(CNS(=O)(=O)C(C)C)c1ccc(-c2ccc(CCN)cc2)cc1.COc1cccc(C(=O)Cl)c1>>COc1cccc(C(=O)NCCc2ccc(-c3ccc(C(C)CNS(=O)(=O)C(C)C)cc3)cc2)c1",
        "output": "271"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CS(=O)(=O)NCCc1ccc(-c2c(Cl)cc(N)cc2C(F)(F)F)cc1.S=C(Cl)Cl.c1ccccc1>>CS(=O)(=O)NCCc1ccc(-c2c(Cl)cc(N=C=S)cc2C(F)(F)F)cc1",
        "output": "114"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CNC[C@H](CN2CCCC2)C1.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1CC(=O)O.On1nnc2ccccc21>>Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1CC(=O)N1CCC[C@@H](CN2CCCC2)C1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C(C)(C)CCCCOc1ccc(OCCCCCn2ccnc2)cc1.CO.O.[Na+].[OH-]>>CC(C)(CCCCOc1ccc(OCCCCCn2ccnc2)cc1)C(=O)O",
        "output": "281"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Oc1c(C)c(C)c2c(c1C)CCC(C)(C(=O)Nc1ccccc1)O2.CC(=O)Oc1cc2c(cc1C(C)(C)C)OC(C)(C(=S)Nc1ccccc1)CC2>>CC1(C(=S)Nc2ccccc2)CCc2cc(O)c(C(C)(C)C)cc2O1",
        "output": "22"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1sc(NC(=O)c2ccccc2)nc1-c1ccccc1.O.[Li+].[OH-]>>O=C(Nc1nc(-c2ccccc2)c(C(=O)O)s1)c1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CNCCN1.COc1ccc(Nc2nc(Cl)cc(-c3ccccc3)n2)cc1Cl>>COc1ccc(Nc2nc(-c3ccccc3)cc(N3CCNCC3)n2)cc1Cl",
        "output": "162"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CN1CCC(O)CC1.O=Cc1ccc(O)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN1CCC(Oc2ccc(C=O)cc2)CC1",
        "output": "846"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC1C=C(C(=O)OCC(Cl)(Cl)Cl)N2C(=O)C(N)[C@H]2S1.CCN(CC)CC.CN(C)c1ccccc1.Cl.Cl.ClCCl.N#CCC(=O)O>>CC1C=C(C(=O)OCC(Cl)(Cl)Cl)N2C(=O)C(NC(=O)CC#N)[C@H]2S1",
        "output": "133"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.Oc1ccc(C[C@H]2CCc3ccccc3O2)cc1>>CC(=O)Oc1ccc(C[C@H]2CCc3ccccc3O2)cc1",
        "output": "46"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc(F)c(Oc2cc(Cl)cc(C#N)c2)c1Cl.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>N#Cc1cc(Cl)cc(Oc2c(F)ccc(CBr)c2Cl)c1",
        "output": "29"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1nc2ccc(I)cc2c(Cl)c1S(C)(=O)=O.O[C@H]1CCCNC1>>Cc1nc2ccc(I)cc2c(N2CCC[C@H](O)C2)c1S(C)(=O)=O",
        "output": "398"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCCOCCOc1cccc([N+](=O)[O-])c1.CCO.[3H][3H].[H][H].[OH-].[OH-].[Pd+2]>>CC(C)(C)OC(=O)NCCOCCOc1cccc(N)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(=O)(=O)c1ccc(C(=O)O)c(Cl)c1.Nc1ccc(Cl)c(-c2ccccn2)c1>>CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(-c3ccccn3)c2)c(Cl)c1",
        "output": "50"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCCCC(Br)C1CCN(C(=O)OC(C)(C)C)CC1.CC(C)=O.CCOC(C)=O.C[N+]1([O-])CCOCC1.O.O=[Os](=O)(=O)=O.[Na+].[O-][I+3]([O-])([O-])[O-]>>CC(C)(C)OC(=O)N1CCC(C(Br)CCCC=O)CC1",
        "output": "571"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(c2nccs2)=CCC3(C)C)cc1.O>>CC1(C)CC=C(c2nccs2)c2cc(C#Cc3ccc(C(=O)O)cc3)ccc21",
        "output": "5"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)c1cc(C2CC2)c(OCC2CCN(C(c3ccc(F)cc3Cl)C(F)(F)F)CC2)cc1F.COC(=O)c1cc(C2CC2)c(O[C@@H]2CCCN([C@@H](C)c3cc(Cl)cc(Cl)c3)C2)cc1F>>O=C(O)c1cc(C2CC2)c(OCC2CCN(C(c3ccc(F)cc3Cl)C(F)(F)F)CC2)cc1F",
        "output": "222"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CCN(CC)CCNC(=O)c1c(C)[nH]c(C=O)c1C.CCO.O=C1Cc2c(cccc2-c2ccc(Br)cc2)N1>>CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3cccc(-c4ccc(Br)cc4)c32)c1C",
        "output": "440"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(Cl)c(CN(Cc2cccc(CN3C(C(=O)O)CCS3(=O)=O)c2)[C@H](CN(C)C)CC(C)(C)C)c1F.Cl.NC1C2CC3CC(C2)CC1C3>>COc1ccc(Cl)c(CN(Cc2cccc(CN3C(C(=O)NC4C5CC6CC(C5)CC4C6)CCS3(=O)=O)c2)[C@H](CN(C)C)CC(C)(C)C)c1F",
        "output": "216"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCN1.CC(C)(C)OC(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)O>>CC(C)(C)OC(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N1CCOCC1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)N1CCC(N)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1[nH]c(C(=O)O)c(C)c1Br.ClCCl.F[P-](F)(F)(F)(F)F>>Cc1[nH]c(C(=O)NC2CCN(C(C)C)CC2)c(C)c1Br",
        "output": "137"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)C=Cc2cccc(C(=O)O)c2N1.CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.C[C@H]1C[C@]2(CCN1)C(NC1CCCCC1)=NC(=O)N2c1cccc(F)c1.F[P-](F)(F)(F)(F)F.O>>C[C@H]1C[C@]2(CCN1C(=O)c1cccc3c1NC(C)(C)C=C3)C(NC1CCCCC1)=NC(=O)N2c1cccc(F)c1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(CC)CC.COc1ccc(C(F)(F)F)c(-c2cc[n+]([O-])cc2)c1.C[Si](C)(C)C#N>>COc1ccc(C(F)(F)F)c(-c2ccnc(C#N)c2)c1",
        "output": "720"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3cc(C(=O)O)n(C)n3)nc21.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNC.F[P-](F)(F)(F)(F)F.O>>CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3cc(C(=O)N(C)C)n(C)n3)nc21",
        "output": "663"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1ccccc1-c1cc2ccccc2[nH]1.O=C(O)CCc1ccccc1>>O=C(CCc1ccccc1)Nc1ccccc1-c1cc2ccccc2[nH]1",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCOC(C)=O.NCCCO.O.O=C(Cl)OCC1c2ccccc2-c2ccccc21.O=C([O-])O.[Na+]>>O=C(NCCCO)OCC1c2ccccc2-c2ccccc21",
        "output": "94"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(OCC)[C@H](C)N(Cc1cccc2cccnc12)C(=O)[C@H](C)N.CN(CC(=O)O)NC(=O)NCc1ccccc1>>CCOC(OCC)[C@H](C)N(Cc1cccc2cccnc12)C(=O)[C@H](C)NC(=O)CN(C)NC(=O)NCc1ccccc1",
        "output": "133"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C[Mg]Br.O.O=Cc1c(F)ccc(Br)c1F>>CC(O)c1c(F)ccc(Br)c1F",
        "output": "787"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)Cl.CC(C)NC(C)C.CN(C)c1ccncc1.COc1cc(N)ccc1-c1nnc(-c2c(-c3ccccc3)noc2C)o1>>COc1cc(NC(C)=O)ccc1-c1nnc(-c2c(-c3ccccc3)noc2C)o1",
        "output": "9"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=Cc1ccc(OCc2ccccc2)c(OCc2ccccc2)c1.[BH4-].[Na+]>>OCc1ccc(OCc2ccccc2)c(OCc2ccccc2)c1",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCON=C(C(=O)OCC)C1=CSCCO1.CO.[Na+].[OH-]>>C=CCON=C(C(=O)O)C1=CSCCO1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)O.COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(-c5c(C)cc(OC6CN(S(C)(=O)=O)C6)cc5C)ccc(F)c43)ccc21.O.[Na+].[OH-]>>Cc1cc(OC2CN(S(C)(=O)=O)C2)cc(C)c1-c1ccc(F)c2c1CC[C@H]2Oc1ccc2c(c1)OC[C@H]2CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC(NC2CCCCC2)CC1.CC(C)(C)OC(=O)NCC(=O)O.CCN=C=NCCCN(C)C.CCOC(C)=O.Cl.ClC(Cl)Cl.ClC(Cl)Cl.ClCCl.NCC(=O)NCC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)NCC(=O)NCC(=O)NCC(=O)OCc1ccccc1",
        "output": "133"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCN1CCN(c2ccc(N)cc2)CC1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Cl>>CCN1CCN(c2ccc(Nc3nc4ccc(OC)cc4c4c[nH]nc34)cc2)CC1",
        "output": "998"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.OCCCc1cccc(OCc2ccccc2)c1>>CS(=O)(=O)OCCCc1cccc(OCc2ccccc2)c1",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#CCCCC.C1CCNCC1.CC1(C)CCCCc2ccc(Br)cc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCCC#Cc1ccc2c(c1)C(C)(C)CCCC2",
        "output": "659"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCc1nc(-c2ccc(C(F)(F)F)cc2)oc1C(C)Oc1ccc(CCC(=O)OC)c(C)c1.CO.[Na+].[OH-]>>CCc1nc(-c2ccc(C(F)(F)F)cc2)oc1C(C)Oc1ccc(CCC(=O)O)c(C)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CCO.Cc1cc2nncn2nc1Cl>>Cc1cc2nncn2nc1N1CCCCC1",
        "output": "406"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C(OCc1ccccc1)N1CCc2ccc([N+](=O)[O-])cc2CC1.[Cl-].[NH4+].[Zn]>>Nc1ccc2c(c1)CCN(C(=O)OCc1ccccc1)CC2",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OCc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(C(F)(F)F)nn12.CO.[K+].[OH-]>>O=C(Nc1c(Cl)cncc1Cl)c1ccc(CO)n2nc(C(F)(F)F)cc12",
        "output": "348"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)c1cc2c(/C=C/c3cccs3)n[nH]c2cc1F.Cl.[Na+].[OH-]>>O=C(O)c1cc2c(/C=C/c3cccs3)n[nH]c2cc1F",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "B.C1CCOC1.CO.COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(c2)OC(C)C(=O)N3)cc1.CSC>>COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(c2)OC(C)CN3)cc1",
        "output": "363"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#Cc1cnn2c(C(C)(C)O)cc(-c3ccc(Cl)cc3)nc12.NS(=O)(=O)c1ccc(Br)s1>>CC(C)(O)c1cc(-c2ccc(Cl)cc2)nc2c(C#Cc3ccc(S(N)(=O)=O)s3)cnn12",
        "output": "766"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CCN(C(C)C)C(C)C.Cc1oc(C(=O)O)cc1-c1c(Br)cnn1C.ClCCl.F[P-](F)(F)(F)(F)F.N[C@@H](Cc1ccccc1C(F)(F)F)CN1C(=O)c2ccccc2C1=O>>Cc1oc(C(=O)N[C@@H](Cc2ccccc2C(F)(F)F)CN2C(=O)c3ccccc3C2=O)cc1-c1c(Br)cnn1C",
        "output": "714"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.Cn1cc(Br)c(-c2c(F)ccc([N+](=O)[O-])c2F)n1.Cn1ncc(Br)c1-c1c(F)ccc([N+](=O)[O-])c1F.O.[Cl-].[NH4+].[Zn]>>Cn1ncc(Br)c1-c1c(F)ccc(N)c1F",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[O-].CN(C)C=O.Cc1cccc(-c2ncc[nH]2)n1.O.O=C1c2ccccc2C(=O)N1CCCCCCBr.[Na+]>>Cc1cccc(-c2nccn2CCCCCCN2C(=O)c3ccccc3C2=O)n1",
        "output": "276"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCc1cc(N2CCN(c3ccncc3)CC2)ccc1O.CCO.Cl.[H][H].[Pd]>>CCCc1cc(N2CCN(c3ccncc3)CC2)ccc1O",
        "output": "116"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COCCOCCOCCOc1cc(OC(F)F)cc([N+](=O)[O-])c1.O.[Cl-].[Fe].[NH4+]>>COCCOCCOCCOc1cc(N)cc(OC(F)F)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)C(CC1CC1)c1cc(OCC(F)(F)F)cc(-c2ccc(C(F)(F)F)cc2)c1.O.O.[Li+].[OH-]>>O=C(O)C(CC1CC1)c1cc(OCC(F)(F)F)cc(-c2ccc(C(F)(F)F)cc2)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)c1cnc(CCNC(=O)OCc2ccccc2)o1.CO.[Pd]>>CC(C)c1cnc(CCN)o1",
        "output": "574"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCC12CCC(C(=O)O)(CC1)CC2.CO.C[Si](C)(C)C=[N+]=[N-].ClCCl>>CCCCCC12CCC(C(=O)OC)(CC1)CC2",
        "output": "195"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COc1cc([N+](=O)[O-])ccc1N1CCN(CC(F)F)CC1.[H][H].[Pd]>>COc1cc(N)ccc1N1CCN(CC(F)F)CC1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1ccc(OC2CCCCO2)cc1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)O[Na].CCOC(C)=O.CN(c1ccc(Cl)cc1)C1CCNCC1.Cc1ccccc1.O.[Pd+2]>>CN(c1ccc(Cl)cc1)C1CCN(c2ccc(OC3CCCCO3)cc2)CC1",
        "output": "294"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(O)ccc1-c1nc2cnccc2[nH]1.CS(=O)(=O)Cl>>COc1cc(OS(C)(=O)=O)ccc1-c1nc2cnccc2[nH]1",
        "output": "149"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#CCON=C(C(=O)OCC)c1csc(N)n1.C1CCOC1.CO.[Na+].[OH-]>>C#CCON=C(C(=O)O)c1csc(N)n1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(=O)(=O)Cl.C[C@@H](O[C@H]1CCN(C(=O)CCN)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl>>C[C@@H](O[C@H]1CCN(C(=O)CCNS(C)(=O)=O)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "493"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCNCC.CN(C)C=O.CN([C@@H]1CCCc2c(OCC(=O)OC(C)(C)C)cccc21)S(=O)(=O)c1cc(F)cc(C(F)(F)F)c1.O.[H-].[Na+]>>CCN(CC)c1cc(C(F)(F)F)cc(S(=O)(=O)N(C)[C@@H]2CCCc3c(OCC(=O)OC(C)(C)C)cccc32)c1",
        "output": "26"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.CN(C)c1ccccn1.NCC1(O)CCCCCC1.O=C(O)c1cc(-c2cc(C3CC3)[nH]n2)ccc1Cl.O=C([O-])[O-].O=C(n1ccnc1)n1ccnc1.On1nnc2ccccc21>>O=C(NCC1(O)CCCCCC1)c1cc(-c2cc(C3CC3)[nH]n2)ccc1Cl",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.CN(C)S(=O)(=O)c1ccc(Br)cc1C(=O)O.Cc1ccc(NC(=O)C2(c3ccc4c(c3)OCO4)CC2)cc1B1OC(C)(C)C(C)(C)O1.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(NC(=O)C2(c3ccc4c(c3)OCO4)CC2)cc1-c1ccc(S(=O)(=O)N(C)C)c(C(=O)O)c1",
        "output": "933"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCc2ccc3c(c2)N(CCO)CC3(C)C)cc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O>>COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCc2ccc3c(c2)N(CCOS(=O)(=O)c2ccc(C)cc2)CC3(C)C)cc1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)Cn1ncc2c(=O)[nH]c3ccc(C)cc3c21.CI.CN(C)C=O.O.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)Cn1ncc2c(=O)n(C)c3ccc(C)cc3c21",
        "output": "191"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=Cc1ccc(OC(C)=O)cc1.NS(=O)(=O)CC1CCNC1>>C=Cc1ccc(O)cc1",
        "output": "22"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1nn(-c2ccc(CCNC(=O)Oc3ccccc3)cc2)c(C)c1-c1ccccc1.NS(=O)(=O)c1ccc(Cl)cc1>>Cc1nn(-c2ccc(CCNC(=O)NS(=O)(=O)c3ccc(Cl)cc3)cc2)c(C)c1-c1ccccc1",
        "output": "690"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1([C@@H]2CC[C@H](N)CC2)CCCCC1.CCN(CC)CC.COCc1ncnc(Cl)c1OC.Cc1ccccc1>>COCc1ncnc(N[C@@H]2CC[C@H](C3(C)CCCCC3)CC2)c1OC",
        "output": "110"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ncn(CCS(=O)(=O)c2ccc(C(=O)O)cc2)n1.Nc1ccc(Cl)c(-c2ccccn2)c1>>Cc1ncn(CCS(=O)(=O)c2ccc(C(=O)Nc3ccc(Cl)c(-c4ccccn4)c3)cc2)n1",
        "output": "50"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CSc1ncc(S(=O)(=O)NC(=O)NC(C)C)c(Nc2cccc(C)c2)n1.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cc1cccc(Nc2nc(S(C)=O)ncc2S(=O)(=O)NC(=O)NC(C)C)c1",
        "output": "595"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COc1cc(B2OC(C)(C)C(C)(C)O2)ccc1O.Cl[Pd]Cl.Nc1ncc(Br)cc1-c1nc2ncccc2o1.[Cs+].[F-].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc(-c2cnc(N)c(-c3nc4ncccc4o3)c2)ccc1O",
        "output": "938"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=C(C)C(=O)Cl.CC1(O)C2CC3CC(C2)CC1C3.c1ccncc1>>C=C(C)C(=O)OC1(C)C2CC3CC(C2)CC1C3",
        "output": "320"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.COc1cc2nc(-c3cccc([N+](=O)[O-])c3)[nH]c(=O)c2cc1O.c1ccncc1>>COc1cc2nc(-c3cccc([N+](=O)[O-])c3)[nH]c(=O)c2cc1OC(C)=O",
        "output": "46"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CO.COC(=O)c1cc(-n2cccc2)cc([N+](=O)[O-])c1.Cl.O.[Fe]>>COC(=O)c1cc(N)cc(-n2cccc2)c1",
        "output": "481"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1ccc(OC2CCNCC2)cc1.C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(C)=O.CN(C)c1ccncc1.Cl>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(Br)cc2)CC1",
        "output": "694"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)c1cccc(Nc2c(C#N)cnc3cnc(F)cc23)c1.NCCN1CCOCC1>>COC(=O)c1cccc(Nc2c(C#N)cnc3cnc(NCCN4CCOCC4)cc23)c1",
        "output": "810"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=O.CC(=O)O.ClCCl.O=C(N1CCNCC1)C1(c2ccc(OCCCN3CCCOCC3)cc2)CCOCC1>>CN1CCN(C(=O)C2(c3ccc(OCCCN4CCCOCC4)cc3)CCOCC2)CC1",
        "output": "217"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.N#CCc1ccc(C(=O)O)cc1.O.O=S(=O)([O-])O.[BH4-].[K+].[Na+]>>N#CCc1ccc(CO)cc1",
        "output": "72"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCOCC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)CC(=O)O.COc1cccc(C(=O)Nc2ccc(OCCN)c(-c3ccnn3C)c2)c1.Cl.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>COc1cccc(C(=O)Nc2ccc(OCCNC(=O)CN(C)C)c(-c3ccnn3C)c2)c1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)N1CCc2[nH]c3c([N+](=O)[O-])cccc3c2C1.CI.COCCOC.[K+].[OH-]>>CCOC(=O)N1CCc2c(c3cccc([N+](=O)[O-])c3n2C)C1",
        "output": "191"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COc1cc(C#N)cc(OC)c1.Cl.NO.O=C([O-])[O-].[K+].[K+]>>COc1cc(OC)cc(C(N)=NO)c1",
        "output": "400"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CNCCN1.CC(C)(C)C(C)(C)Nc1nc(Cl)nc(NC(C)(C)C(C)(C)C)n1.COCCO>>CC(C)(C)C(C)(C)Nc1nc(NC(C)(C)C(C)(C)C)nc(N2CCNCC2)n1",
        "output": "214"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCN(CCCO)C(=O)OCc1ccccc1.CS(=O)(=O)Cl.ClCCl>>CCCN(CCCOS(C)(=O)=O)C(=O)OCc1ccccc1",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.Nc1ccc(Cl)cn1.O=C(CBr)c1ccc(F)cc1F.[Na+].[OH-]>>Fc1ccc(-c2cn3cc(Cl)ccc3n2)c(F)c1",
        "output": "508"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCN1C(=O)C(C)(C)c2cc(NC(=O)CCc3ccccc3)c([N+](=O)[O-])cc21.CI.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCCCCN1C(=O)C(C)(C)c2cc(N(C)C(=O)CCc3ccccc3)c([N+](=O)[O-])cc21",
        "output": "237"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.CN1CCCc2ccccc21.O=P(Cl)(Cl)Cl>>CN1CCCc2cc(C=O)ccc21",
        "output": "239"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc2[nH]c(C(=O)O)cc2c1.Cc1cc(N2CCC(CN3CCCC3C)C2)ccc1N>>COc1ccc2[nH]c(C(=O)Nc3ccc(N4CCC(CN5CCCC5C)C4)cc3C)cc2c1",
        "output": "548"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cccc(C(F)(F)F)c1.O=C(O)C1CCN(c2nsnc2OCc2ccncc2)CC1>>O=C(Nc1cccc(C(F)(F)F)c1)C1CCN(c2nsnc2OCc2ccncc2)CC1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NC(=O)Cc1csc(N)n1.O=P(Cl)(Cl)Cl>>N#CCc1csc(N)n1",
        "output": "172"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1NCCc2occc21.O=C(O)c1cc2ncc(Cl)cn2n1>>CN1c2ccoc2CCN1C(=O)c1cc2ncc(Cl)cn2n1",
        "output": "995"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN.Cl.NC(=O)c1cc(Cl)nc(Cl)n1>>CNc1cc(C(N)=O)nc(Cl)n1",
        "output": "166"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)c1ccc(-c2cc(NC(=O)N3CCOCC3)ccc2C)cc1.[Na+].[OH-]>>Cc1ccc(NC(=O)N2CCOCC2)cc1-c1ccc(C(=O)O)cc1",
        "output": "5"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.C[C@@H](O)CSc1cccc(-c2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)c1.O.O=S([O-])OO.[K+]>>C[C@@H](O)CS(=O)(=O)c1cccc(-c2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)c1",
        "output": "730"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.CS(N)(=O)=O.ClCCl.O=C(Nc1ccc(N2CCC(C(=O)O)CC2)nc1)c1nc(-c2ccccc2)oc1C(F)(F)F>>CS(=O)(=O)NC(=O)C1CCN(c2ccc(NC(=O)c3nc(-c4ccccc4)oc3C(F)(F)F)cn2)CC1",
        "output": "644"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.Nc1cc(C(F)(F)F)cnc1S.O.O=C(O)c1ncccc1Cl.On1nnc2ccccc21.c1ccncc1>>O=C(Nc1cc(C(F)(F)F)cnc1S)c1ncccc1Cl",
        "output": "776"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CNC(=O)CC(c1ccc2cc[nH]c2c1)c1ccccc1OC.CNCCC(c1ccccc1)c1cccc2cc[nH]c12>>CNCCC(c1ccc2cc[nH]c2c1)c1ccccc1OC",
        "output": "112"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.NC(=O)c1sc(-n2cnc3cnc(CO)cc32)cc1OC(c1ccccc1Cl)C(F)(F)F>>CS(=O)(=O)OCc1cc2c(cn1)ncn2-c1cc(OC(c2ccccc2Cl)C(F)(F)F)c(C(N)=O)s1",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrBr.CC(=O)O.CCc1ccc(C(=O)O)cc1.O.O=[N+]([O-])O.O=[N+]([O-])[O-].[Ag+]>>CCc1ccc(C(=O)O)cc1Br",
        "output": "98"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)O.Cl.NCCc1c[nH]c(=S)n1[C@H]1COc2c(F)cc(F)cc2C1.O=Cc1ccccc1.[Na+]>>Fc1cc(F)c2c(c1)C[C@@H](n1c(CCNCc3ccccc3)c[nH]c1=S)CO2",
        "output": "468"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.O=C(O)c1ccc2nc[nH]c2c1.O=S(=O)(O)O.O=S(=O)([O-])[O-].[Ca+2]>>COC(=O)c1ccc2nc[nH]c2c1",
        "output": "33"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1noc(N2CCC(NC3CC3)CC2)n1.Cc1ncnn1-c1ccc(C(=O)O)cc1F>>Cc1ncnn1-c1ccc(C(=O)N(C2CC2)C2CCN(c3nc(C(C)C)no3)CC2)cc1F",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1ccc(S(=O)(=O)OCCCl)cc1.O.O=C([O-])[O-].O=Cc1ccccc1O.[K+].[K+]>>O=Cc1ccccc1OCCCl",
        "output": "438"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOC(=O)c1ccc(N2CCNCC2)cc1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.Nc1c(Cl)cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc1C(F)(F)F>>CCOC(=O)c1ccc(N2CCN(C(=O)[C@@H](Cc3cc(Cl)c(N)c(C(F)(F)F)c3)OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)cc1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)O)c(OC)cc3C)cc12.Cl.NC1(c2cccnn2)CC1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5cccnn5)CC4)c(OC)cc3C)cc12",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.OCC1Cc2cccc(Br)c2O1>>Cc1ccc(S(=O)(=O)OCC2Cc3cccc(Br)c3O2)cc1",
        "output": "197"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COc1ccc([N+](=O)[O-])c2cc[nH]c12.[Pd]>>COc1ccc(N)c2cc[nH]c12",
        "output": "202"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CN(C)C=O.CN1C(=O)COc2ccccc21.COc1ccc(Cl)c(CC(=O)O)c1.Cl.ClCCCl.O=C(Cl)C(=O)Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(Cl)c(CC(=O)c2ccc3c(c2)N(C)C(=O)CO3)c1",
        "output": "435"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.ClCCl.NCCN1CCOCC1.O=C(O)c1cc([N+](=O)[O-])cc(C(F)(F)F)c1.O=S(Cl)Cl>>O=C(NCCN1CCOCC1)c1cc([N+](=O)[O-])cc(C(F)(F)F)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.O=C1CSC(c2cccc(F)c2)N1CCCCl>>O=C1CSC(c2cccc(F)c2)N1CCCN1CCOCC1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cl[Pd]Cl.Clc1ccc(Cl)nc1.OB(O)c1ccccc1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1>>Clc1ccc(-c2ccccc2)nc1",
        "output": "865"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.COc1cccc(CC(=O)O)c1.ClI.II.O>>COc1ccc(I)c(CC(=O)O)c1",
        "output": "466"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COc1ccc2nn(-c3ccc(OCc4ccccc4)cc3)cc2c1.[Pd]>>COc1ccc2nn(-c3ccc(O)cc3)cc2c1",
        "output": "698"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC1CCc2cc(Br)ccc2NC1=O.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccccc1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(C)OC(=O)NC1CCc2cc(-c3ccccc3)ccc2NC1=O",
        "output": "837"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1c2[nH]c3ccc(Cl)cc3c2CCN1C.CN(C)C=O.COc1ccc(C(C)=CBr)cc1.O=C(O)[C@@H]1CCCN1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>COc1ccc(C(C)=Cn2c3c(c4cc(Cl)ccc42)CCN(C)C3C)cc1",
        "output": "987"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "FC(F)(F)c1nnc2ccc(Cl)nn12.c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>FC(F)(F)c1nnc2ccc(N3CCN(C(c4ccccc4)c4ccccc4)CC3)nn12",
        "output": "406"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OC[C@@]1(C(=O)O)CC[C@H](c2ccc(OCc3ccccc3F)cc2)N1C(=O)OCc1ccccc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CNC.F[B-](F)(F)F>>CN(C)C(=O)[C@]1(CO[Si](C)(C)C(C)(C)C)CC[C@H](c2ccc(OCc3ccccc3F)cc2)N1C(=O)OCc1ccccc1",
        "output": "685"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(=O)Cl.COc1cc(-c2ncnc3c(C(=O)NC4CCNCC4)c[nH]c23)c(OCC2CC2)cc1F.Cl>>CCC(=O)N1CCC(NC(=O)c2c[nH]c3c(-c4cc(OC)c(F)cc4OCC4CC4)ncnc23)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCCCO.CSc1c(O)cccc1O>>CSc1c(O)cccc1OCCCCNC(=O)OC(C)(C)C",
        "output": "550"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CS(=O)(=O)c1ccc(SCC(F)(F)F)c(C(=O)O)c1.FC(F)(F)c1ccc(N2CCNCC2)cc1>>CS(=O)(=O)c1ccc(SCC(F)(F)F)c(C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COCCOC.Cc1cc(C(=O)Nc2ccc(S(C)(=O)=O)cc2)c(C)n1-c1ccccc1Br.Cl[Pd]Cl.O=C([O-])[O-].OB(O)c1cccc(Cl)c1.[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cc(C(=O)Nc2ccc(S(C)(=O)=O)cc2)c(C)n1-c1ccccc1-c1cccc(Cl)c1",
        "output": "837"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2c(c1)OCCc1cc(-c3n[nH]c(=O)n3-c3ccccc3Cl)sc1-2>>CNC(=O)c1ccc2c(c1)OCCc1cc(-c3n[nH]c(=O)n3-c3ccccc3Cl)sc1-2",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(C)=O.CN.O[C@@H](CCl)c1ccc(F)cn1>>CNC[C@H](O)c1ccc(F)cn1",
        "output": "279"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)C(N)C=C(CC(C)O)CP(=O)(O)O.O>>CC(O)CC(=CC(N)C(=O)O)CP(=O)(O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCBr.CCN(C(C)C)C(C)C.CN(C)C=O.NC(=O)Cc1cccnc1CCc1nc(Nc2ccc(C3CCCNC3)cc2)ncc1C(F)(F)F>>CCN1CCCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ncccc4CC(N)=O)n3)cc2)C1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCNCC.N#Cc1c(Cl)nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c1-c1ccc(OCCO)cc1.O>>CCN(CC)c1nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c(-c2ccc(OCCO)cc2)c1C#N",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C1COCCN1.CC(C)(C)P(c1ccccc1-c1ccccc1)C(C)(C)C.CC(C)(C)[O-].Cc1cc(Br)cc([N+](=O)[O-])c1N.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1cc(N2CCOCC2)cc([N+](=O)[O-])c1N",
        "output": "294"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.CCCCP(CCCC)CCCC.COC(=O)Cc1cccc(C)c1O.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CCC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCOc1c(C)cccc1CC(=O)O",
        "output": "928"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cccc(N)n1.O=C([O-])[O-].O=S(=O)(O)O.O=[N+]([O-])O.[Na+].[Na+]>>Cc1ccc([N+](=O)[O-])c(N)n1",
        "output": "328"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CC2(CCN1)OCCO2.CCN(CC)CC.CCO.Clc1ccnc(Cl)n1>>Clc1nccc(N2CCC3(CC2)OCCO3)n1",
        "output": "162"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCCCCCBr.CC(C)=O.COC(=O)COc1ccc2ccc(O)c(C(C)=O)c2c1.O=C([O-])[O-].[K+].[K+]>>COC(=O)COc1ccc2ccc(OCCCCCBr)c(C(C)=O)c2c1",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "FC(F)(F)c1ccccc1.O=S(=O)(O)Cl.O=S(=O)(O)O.O=S(=O)=O>>O=S(=O)(Cl)c1cccc(C(F)(F)F)c1",
        "output": "357"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.CN(c1nc(Cl)ncc1Cl)C1CCN(c2ccc(C#N)cn2)CC1.Cl.Cn1cc(N)cn1>>CN(c1nc(Nc2cnn(C)c2)ncc1Cl)C1CCN(c2ccc(C#N)cn2)CC1",
        "output": "992"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C(CN)N2CCCCC2)cc1.O=C(O)c1cccc(Cl)c1Cl>>COc1ccc(C(CNC(=O)c2cccc(Cl)c2Cl)N2CCCCC2)cc1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.CCOC(=O)C(Cl)Cc1ccc(OCC2(C)CCc3c(C)c(OC(C)=O)c(C)c(C)c3O2)cc1.Cl.[Na+].[OH-]>>CC(=O)Oc1c(C)c(C)c2c(c1C)CCC(C)(COc1ccc(CC(Cl)C(=O)O)cc1)O2",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC1CC(CNc2ccccc2)CCC1N.O=C(Cl)c1cc(C(F)(F)F)ccc1Cl>>CC1CC(CNc2ccccc2)CCC1NC(=O)c1cc(C(F)(F)F)ccc1Cl",
        "output": "271"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC1CCNCC1.CCCCCC.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.COC(=O)/C(Cc1ccc(C(=O)O)cc1)=C(\\C(=O)OC)C(C)C.Cl.Cl.ClCCl.O.On1nnc2ccccc21>>COC(=O)/C(Cc1ccc(C(=O)N2CCC(OC(C)=O)CC2)cc1)=C(\\C(=O)OC)C(C)C",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc(CNS(C)(=O)=O)c(OCC2CC2)c1.Cl.[Li+].[OH-]>>CS(=O)(=O)NCc1ccc(C(=O)O)cc1OCC1CC1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)[C@H]1CCNC1.CS(C)=O.O.O=C([O-])[O-].O=Cc1cccc(Br)c1F.[K+].[K+]>>CN(C)[C@H]1CCN(c2c(Br)cccc2C=O)C1",
        "output": "868"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc(-c2ccccc2C(=O)O)cc1.Cc1nc2sccn2c1C(=O)NC[C@H]1NC[C@@H]2CC(C)C[C@@H]21>>Cc1ccc(-c2ccccc2C(=O)N2C[C@@H]3CC(C)C[C@@H]3[C@H]2CNC(=O)c2c(C)nc3sccn23)cc1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNC1.CCO.CN1CCC(=O)CC1.CO.N.N#Cc1ccc2[nH]ccc2c1>>CN1CC=C(c2c[nH]c3ccc(C#N)cc23)CC1",
        "output": "607"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClC(Cl)Cl.Cn1nc2c(ccc3cc(CO)ccc32)c1-c1ccc(OC(F)(F)F)cc1.O=[Mn]=O>>Cn1nc2c(ccc3cc(C=O)ccc32)c1-c1ccc(OC(F)(F)F)cc1",
        "output": "179"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccccn1.CN1C(=O)CCc2ccc(N)cc21.Cl.ClCCl.O=C(O)c1ccc(Cl)cc1N[C@H]1CCCC[C@@H]1N1CCCC1>>CN1C(=O)CCc2ccc(NC(=O)c3ccc(Cl)cc3N[C@H]3CCCC[C@@H]3N3CCCC3)cc21",
        "output": "50"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cc(F)cc(Br)c1>>O=C(Cl)c1cc(F)cc(Br)c1",
        "output": "448"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@H](NC(=O)OCc1cccc2c1Cc1ccccc1-2)C(=O)OC(C)(C)C)OC(=O)CCCCCCCCCCCCCCC.O=C(O)C(F)(F)F>>CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@H](NC(=O)OCc1cccc2c1Cc1ccccc1-2)C(=O)O)OC(=O)CCCCCCCCCCCCCCC",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCN(c2ccc(-c3nc4c(-c5ccc(OC6CCNCC6)c(C#N)c5)ncnc4[nH]3)cc2)CC1.F[P-](F)(F)(F)(F)F.O=C(O)CO>>CN1CCN(c2ccc(-c3nc4c(-c5ccc(OC6CCN(C(=O)CO)CC6)c(C#N)c5)ncnc4[nH]3)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)c1ccc(-c2ccc(F)cc2)s1.[Na+].[OH-]>>O=C(O)c1ccc(-c2ccc(F)cc2)s1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.COc1ccc(C=O)cc1OC1CCCC1.O.[BH4-].[Na+]>>COc1ccc(CO)cc1OC1CCCC1",
        "output": "356"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(Cl)C(=O)Cl.CC1NCCc2ccccc21.Cc1ccccc1>>CC(Cl)C(=O)N1CCc2ccccc2C1C",
        "output": "240"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(CN)O[N+](=O)[O-].O=C1N[C@H](C(=O)O)CS1.O=[N+]([O-])O>>CC(CNC(=O)[C@@H]1CSC(=O)N1)O[N+](=O)[O-]",
        "output": "216"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(C)(C)C.COc1cccc(CO)c1F.ClCCl.O=C([O-])[O-].O=S(Cl)Cl.[K+].[K+]>>COc1cccc(CCl)c1F",
        "output": "81"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)N.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ncc(Br)cn1.c1ccncc1>>CC(C)(C)NC(=O)c1ncc(Br)cn1",
        "output": "951"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(Cl)OC(=O)Cl.ClCCCl.Fc1ccc2c(c1)C1(CCN(Cc3ccccc3)CC1)OC2>>Fc1ccc2c(c1)C1(CCNCC1)OC2",
        "output": "84"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCO.CCOC(=O)NC1(CN2CCN(C(=O)OCc3ccccc3)CC2=O)CCNCC1.Cc1cc(Cl)ccn1.Cl>>CCOC(=O)NC1(CN2CCN(C(=O)OCc3ccccc3)CC2=O)CCN(c2ccnc(C)c2)CC1",
        "output": "398"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(OC)c(-c2cc(C(=O)O)c(C)n2CC2CCCCC2)c1.NCCCO>>COc1ccc(OC)c(-c2cc(C(=O)NCCCO)c(C)n2CC2CCCCC2)c1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cl.N#Cc1ccc2c(c1)c(Br)nn2C1CCCCO1>>N#Cc1ccc2[nH]nc(Br)c2c1",
        "output": "689"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(C(C)(C)C)cc1.O=S(=O)(O)O.O=[N+]([O-])O>>Cc1ccc(C(C)(C)C)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)/C=C/C(=O)c1nn(-c2cccc(S(C)(=O)=O)c2)ccc1=O.Cc1cccc(NN)c1C>>Cc1cccc(-n2nccc2-c2nn(-c3cccc(S(C)(=O)=O)c3)ccc2=O)c1C",
        "output": "984"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1ccc2[nH]ccc2c1.CCI.CN(C)C=O.[H-].[H][H].[Na+]>>CCn1ccc2cc(Br)ccc21",
        "output": "302"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)c1cc(-c2ccccc2)nn1C.Cl.[Na+].[OH-]>>Cn1nc(-c2ccccc2)cc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C1(CC)CC=CC1.CO.[Na+].[OH-]>>CCC1(C(=O)O)CC=CC1",
        "output": "281"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C[C@H](N)C(F)(F)F.C[C@H](N)CO.Nc1cnc(-c2ccc(-c3ccccc3C(=O)O)cc2F)cn1>>C[C@@H](CO)NC(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)n1cc(C(=O)c2ccc(C#N)c(N)c2)c2cncnc21.Cc1cc(C(F)(F)F)nn1CC(=O)O>>Cc1cc(C(F)(F)F)nn1CC(=O)Nc1cc(C(=O)c2cn(C(C)C)c3ncncc23)ccc1C#N",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(Cl)Cl.COc1ccccc1.O=C(Cl)C1CCCCC1.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(C(=O)C2CCCCC2)cc1",
        "output": "31"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.Cc1cc(C)nc(N2CC3CNCC3C2)n1.O=C(O)c1ccccc1-n1cnnc1>>Cc1cc(C)nc(N2CC3CN(C(=O)c4ccccc4-n4cnnc4)CC3C2)n1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1cccnc1.C#CCO.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.I[Cu]I>>OCC#Cc1cccnc1",
        "output": "719"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1ccc(Cl)nc1)C2.O.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1ccc(OC)nc1)C2",
        "output": "433"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.Cl.Cl.ClCCl.Nc1ccc(NC(=O)CN2CCC(Cc3ccc(F)cc3)CC2)cc1>>CC(=O)Nc1ccc(NC(=O)CN2CCC(Cc3ccc(F)cc3)CC2)cc1",
        "output": "6"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCOC(=O)c1c(-c2ccc(F)cc2)oc2cc(N3CCCC3=O)c(Br)cc12.O.[Li+].[OH-]>>O=C(O)c1c(-c2ccc(F)cc2)oc2cc(N3CCCC3=O)c(Br)cc12",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.FC(F)[C@@H]1Cc2ccccc2N1.O=C(Cl)CCl>>O=C(CCl)N1c2ccccc2C[C@H]1C(F)F",
        "output": "160"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CNCCN1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.ClCCl.O.O=C(O)c1cc(C(=O)NCCc2ccc(-c3ccc(Cl)c(Cl)c3)o2)[nH]n1.On1nnc2ccccc21>>O=C(NCCc1ccc(-c2ccc(Cl)c(Cl)c2)o1)c1cc(C(=O)N2CCNCC2)n[nH]1",
        "output": "663"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](Nc2ccccn2)C[C@@H]1C.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NC(CO)CO>>CC(=O)N1c2ccc(-c3ccc(C(=O)NC(CO)CO)cc3)cc2[C@H](Nc2ccccn2)C[C@@H]1C",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(O)C#Cc1cnc([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)F)c3c2C(F)(F)CCC3(F)F)c(Br)c1.Cn1nc(NS(C)(=O)=O)c2c(Cl)ccc(-c3ccc(C#CC(C)(C)O)nc3[C@@H](N)Cc3cc(F)cc(F)c3)c21.O=C(O)Cn1nc(C(F)F)c2c1C(F)(F)[C@@H]1C[C@H]21>>Cn1nc(NS(C)(=O)=O)c2c(Cl)ccc(-c3ccc(C#CC(C)(C)O)nc3[C@H](Cc3cc(F)cc(F)c3)NC(=O)Cn3nc(C(F)F)c4c3C(F)(F)[C@@H]3C[C@H]43)c21",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.C1COCCN1.O=[N+]([O-])c1ccc(F)cc1F.O=[N+]([O-])c1ccc(N2CCOCC2)cc1F>>O=[N+]([O-])c1ccc(F)cc1N1CCOCC1",
        "output": "26"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)CCN(CC(=O)N1CCc2cc(OCc3ccccc3)ccc21)C(=O)OC(C)(C)C.CO.[Pd]>>CC(C)(C)OC(=O)CCN(CC(=O)N1CCc2cc(O)ccc21)C(=O)OC(C)(C)C",
        "output": "698"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(Oc1ccc(C#N)cn1)C1CN(C(=O)Cl)CC1c1ccc(Cl)c(Cl)c1.CCN(CC)CC.ClCCl.N#CC1CCNCC1>>CC(Oc1ccc(C#N)cn1)C1CN(C(=O)N2CCC(C#N)CC2)CC1c1ccc(Cl)c(Cl)c1",
        "output": "258"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCn1cc(-c2cccc(N)c2)c(-c2ccnc(N)n2)n1.ClCCl.O=C=Nc1ccc(Br)c(F)c1>>CCn1cc(-c2cccc(NC(=O)Nc3ccc(Br)c(F)c3)c2)c(-c2ccnc(N)n2)n1",
        "output": "473"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.C[C@@H]1[C@@H]2CC[C@@H]([C@H](O)C2)N1C(=O)c1cccc(F)c1-c1ncccn1.FC(F)(F)c1ccc(Cl)nc1.[H-].[Na+]>>C[C@@H]1[C@@H]2CC[C@@H]([C@H](Oc3ccc(C(F)(F)F)cn3)C2)N1C(=O)c1cccc(F)c1-c1ncccn1",
        "output": "433"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COC(=O)c1ccccc1-c1ccc(CO)cc1.CS(=O)(=O)Cl.ClCCl.O>>COC(=O)c1ccccc1-c1ccc(COS(C)(=O)=O)cc1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COc1ccc(C(=O)O)cc1N.O=S(=O)(O)O>>COC(=O)c1ccc(OC)c(N)c1",
        "output": "33"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)Cc1c(O)nc(S)nc1O.CN(C)C=O.Fc1cccc(CBr)c1F.O.[H-].[Na+]>>CCOC(=O)Cc1c(O)nc(SCc2cccc(F)c2F)nc1O",
        "output": "699"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O.CC(C)(C)O.CCOC(=O)c1cnc(Cn2c(C)cc(OCc3ccc(F)cc3F)c(Br)c2=O)cn1.CO.[BH4-].[Na+]>>Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1Cc1cnc(CO)cn1",
        "output": "286"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CC(C)=O.CCCc1ccc(OS(=O)(=O)c2ccc(C)cc2)c(O)c1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CCCc1ccc(OS(=O)(=O)c2ccc(C)cc2)c(OCc2ccccc2)c1",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ncccc1-c1ccc2c(c1)C(C)NCC2.O=C(O)c1cc2ncc(Cl)cn2n1>>COc1ncccc1-c1ccc2c(c1)C(C)N(C(=O)c1cc3ncc(Cl)cn3n1)CC2",
        "output": "952"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCNc1cccc2c(-c3ccnc(NCCCC)n3)c(-c3ccc(F)cc3)nn12.CCO.[H][H].[Pd]>>CCCCNc1nccc(-c2c(-c3ccc(F)cc3)nn3c(NCCC)cccc23)n1",
        "output": "116"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCc1sc2c(c1CCBr)CCN(C(C)=O)C2.Cl.Fc1ccc2c(C3CCNCC3)noc2c1.O=C([O-])C(=O)[O-]>>CCc1sc2c(c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCN(C(C)=O)C2",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cccnc1Nc1cc(Cl)cc(OC)c1.O.[Li+].[OH-]>>COc1cc(Cl)cc(Nc2ncccc2C(=O)O)c1",
        "output": "152"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)CNC(=O)c1ccc(OC(F)(F)F)cc1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)CNC(=O)c1ccc(OC(F)(F)F)cc1",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCc1nn(Cc2cccc(OC)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12.Cl.O=C([O-])O.[Na+]>>CCc1nn(Cc2cccc(O)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12",
        "output": "408"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CCCC1=O.COC(=O)Cc1ccc([N+](=O)[O-])c(F)c1.COc1ccc(CS)cc1.O.[H-].[Na+]>>COC(=O)Cc1ccc([N+](=O)[O-])c(SCc2ccc(OC)cc2)c1",
        "output": "503"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)c1cc(C2CC2)cnc1Nc1cccc2[nH]ccc12.CCOC(C)=O.Ic1ccccc1.N[C@@H]1CCCC[C@H]1N.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>CC(C)(C)OC(=O)c1cc(C2CC2)cnc1Nc1cccc2c1ccn2-c1ccccc1",
        "output": "267"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1nc(CN(Cc2ccc(SC(C)(C)C(=O)OC(C)(C)C)cc2)c2cc(Cl)ncn2)cs1.O=C([O-])[O-].O=[Cu].Oc1cccc(C(F)(F)F)c1.[K+].[K+].c1ccncc1>>Cc1nc(CN(Cc2ccc(SC(C)(C)C(=O)OC(C)(C)C)cc2)c2cc(Oc3cccc(C(F)(F)F)c3)ncn2)cs1",
        "output": "668"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)O)cn3)nc2n1C1CCCC1.O=C(OCc1ccccc1)N1C2CNCC1COC2>>CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5COCC(C4)N5C(=O)OCc4ccccc4)cn3)nc2n1C1CCCC1",
        "output": "256"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccccc1-c1ccc2c(c1)NC(=O)C2.Cc1[nH]c(C=O)c(C)c1CCCN(C)C>>COc1ccccc1-c1ccc2c(c1)NC(=O)C2=Cc1[nH]c(C)c(CCCN(C)C)c1C",
        "output": "440"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CN(C)C=O.CS(=O)(=O)Cc1ccc(C(=O)O)cc1O.ClCCl.Nc1ccc(Cl)c(-c2ccccn2)c1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=S(Cl)Cl>>CS(=O)(=O)Cc1ccc(C(=O)Nc2ccc(Cl)c(-c3ccccn3)c2)cc1O",
        "output": "50"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1.CO.[H][H].[Pd]>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(N)cc2C(F)(F)F)CC1",
        "output": "202"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(=O)Cl.ClCCl.Nc1ccc(C(F)(F)F)cc1.O=C([O-])O.[Na+]>>CC(C)(C)C(=O)Nc1ccc(C(F)(F)F)cc1",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)C(=O)Cl.COc1cc(O)c2c(=O)c(OC)c(-c3ccc(OC(=O)C(C)(C)C)c(OC)c3)oc2c1.c1ccncc1>>COc1cc(OC(=O)C(C)C)c2c(=O)c(OC)c(-c3ccc(OC(=O)C(C)(C)C)c(OC)c3)oc2c1",
        "output": "111"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.Cc1cc(Br)ccc1S(=O)(=O)Cl.ClCCl.[Cl-].[NH4+]>>Cc1cc(Br)ccc1S(=O)(=O)N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "99"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COc1ccccc1-c1ccc([N+](=O)[O-])cc1.O=C[O-].[NH4+].[Pd]>>COc1ccccc1-c1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCOc1ccnc2c([N+](=O)[O-])cccc12.CC(=O)O.CCO.[Fe]>>C=CCOc1ccnc2c(N)cccc12",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1ccc(NC(=O)c2cccc(NS(=O)(=O)c3ccccc3)c2)cc1.CN1CCCC1=O.CO.Cl.O.[K+].[OH-]>>O=C(O)c1ccc(NC(=O)c2cccc(NS(=O)(=O)c3ccccc3)c2)cc1",
        "output": "5"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(O)CC(CBr)Cc1ccccc1.O=S(Cl)Cl>>O=C(Cl)CC(CBr)Cc1ccccc1",
        "output": "53"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC1CCC(N[C@@H]2C[C@H]2c2ccc(Nc3cccc(C#N)c3)nc2)CC1.Cl>>N#Cc1cccc(Nc2ccc([C@@H]3C[C@H]3NC3CCC(N)CC3)cn2)c1",
        "output": "538"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1cccc2c1nc(C(=O)Nc1ccc(N3CCOCC3=O)cc1)n2Cc1cccc(OC)c1.[Li+].[OH-]>>COc1cccc(Cn2c(C(=O)Nc3ccc(N4CCOCC4=O)cc3)nc3c(C(=O)O)cccc32)c1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CI.CN(C)C=O.Cc1cccc(Nc2nc(Cl)nc(Cl)c2C(=O)O)c1.O=C([O-])O.[Na+]>>COC(=O)c1c(Cl)nc(Cl)nc1Nc1cccc(C)c1",
        "output": "415"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccnc(Br)c1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>BrCc1ccnc(Br)c1",
        "output": "29"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CC(C)(C)[O-].CCOC(=O)N1C[C@H](O)C[C@H]1CCCl.Oc1ccc(Br)cc1CCc1ccccc1.[K+]>>CCOC(=O)N1C[C@H](O)C[C@H]1CCOc1ccc(Br)cc1CCc1ccccc1",
        "output": "74"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COCCOc1ccccc1C(=O)OC.Cl.O.[K+].[OH-]>>COCCOc1ccccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CI.CN(C)C=O.Cl.O.O=C(O)c1ccc2c(C3CCCCC3)c[nH]c2c1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc2c(C3CCCCC3)c[nH]c2c1",
        "output": "415"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCc1nc2c(-c3ccc(C)cc3C)cc(C)nn2c1C(=O)OC.[Na+].[OH-]>>CCc1nc2c(-c3ccc(C)cc3C)cc(C)nn2c1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCI.CN(C)C=O.O.O=C([O-])[O-].Oc1ccc2c(c1)OCO2.[K+].[K+]>>CCOc1ccc2c(c1)OCO2",
        "output": "198"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.C[C@H](C[C@H](C)O)Oc1ccc(-c2ccc(C#N)cc2)cc1.Cl.c1ccncc1>>CC(=O)O[C@@H](C)C[C@@H](C)Oc1ccc(-c2ccc(C#N)cc2)cc1",
        "output": "254"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCOC(=O)[C@@H]1C[C@H]1c1nnc2ccc(-c3c(-c4ccc(F)cc4)nc4occn34)cn12.[Na+].[OH-]>>O=C(O)[C@@H]1C[C@H]1c1nnc2ccc(-c3c(-c4ccc(F)cc4)nc4occn34)cn12",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCl.Nc1ccc(Cl)c(Br)n1.O=C(Cl)c1ccccc1.c1ccncc1>>O=C(Nc1ccc(Cl)c(Br)n1)c1ccccc1",
        "output": "463"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Fc1c(F)c(F)c(CBr)c(F)c1F.N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)O)(CC1)CC2>>N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)OCc3c(F)c(F)c(F)c(F)c3F)(CC1)CC2",
        "output": "403"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.N#Cc1cccc(N)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>N#Cc1cccc(NC(=O)C(F)(F)F)c1",
        "output": "106"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)NC(=O)c1cc(F)c(-c2cnc(F)c(Br)c2)cc1F.CS(C)=O.Cc1cc(Cl)cc(Cl)c1O.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1cc(Cl)cc(Cl)c1Oc1ncc(-c2cc(F)c(C(=O)NS(C)(=O)=O)cc2F)cc1Br",
        "output": "727"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(-n2nc(C(=O)N3CCOCC3)cc2-c2ccc(NC(=O)OC(C)(C)C)nc2)cn1.ClC(Cl)Cl.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>COc1ccc(-n2nc(C(=O)N3CCOCC3)cc2-c2ccc(N)nc2)cn1",
        "output": "885"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1.COc1ccc(COCCCCCBr)cc1OC.Cl.Cl>>COc1ccc(COCCCCCN2CCC(CNC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1OC",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)COC1CCN(Cc2ccccc2)CC1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCOC1CCN(Cc2ccccc2)CC1",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.OCC1CCC1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCC2CCC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)C[C@H](O[C@H](c1ccccc1)c1ccc(-c2cccnc2)cc1)C(=O)NCC#N.ClCCl.O=C(OO)c1cccc(Cl)c1>>CC(C)C[C@H](O[C@H](c1ccccc1)c1ccc(-c2ccc[n+]([O-])c2)cc1)C(=O)NCC#N",
        "output": "262"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CO.Cc1ccc(S(=O)(=O)n2ccc3c(N(C)C4CCC(CS(=O)(=O)N5CC[C@H](CO)C5)CC4C)ncnc32)cc1.O.[Li+].[OH-]>>CC1CC(CS(=O)(=O)N2CC[C@H](CO)C2)CCC1N(C)c1ncnc2[nH]ccc12",
        "output": "949"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.OC[C@H]1OC[C@H](Oc2nc3nc(-c4ccc(Br)cc4)c(Cl)cc3[nH]2)C[C@@H]1O.[K+].[Pd]>>CC1(C)OB(c2ccc(-c3nc4nc(O[C@H]5CO[C@H](CO)[C@@H](O)C5)[nH]c4cc3Cl)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#CCCN.CCN(CC)CC.CS(=O)(=O)Cl.Cl.Cl.ClCCl>>C#CCCNS(C)(=O)=O",
        "output": "493"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COc1cc2c(Cl)ncnc2cc1OCCCN1CCCCC1.O=C([O-])[O-].Oc1ccc2[nH]ccc2c1F.[K+].[K+]>>COc1cc2c(Oc3ccc4[nH]ccc4c3F)ncnc2cc1OCCCN1CCCCC1",
        "output": "668"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)O.N#Cc1ccc(C#N)cc1.[Na+].[OH-]>>N#Cc1ccc(C(N)=O)cc1",
        "output": "419"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COCC(=O)O.Cc1n[nH]c(CN2CCNCC2)c1Oc1cc(Cl)cc(C#N)c1.ClCCl>>COCC(=O)N1CCN(Cc2[nH]nc(C)c2Oc2cc(Cl)cc(C#N)c2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C1COCCN1.O=C(O)c1ccc(CBr)cc1>>O=C(O)c1ccc(CN2CCOCC2)cc1",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1c(C(=O)O)cnn1-c1ccc(Cl)c(Cl)c1.N#Cc1cc(N)ccc1N1CCC(N2CCOCC2)CC1>>Cc1c(C(=O)Nc2ccc(N3CCC(N4CCOCC4)CC3)c(C#N)c2)cnn1-c1ccc(Cl)c(Cl)c1",
        "output": "851"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Clc1ccnc2ccc(SC3CCOCC3)cc12.O.O=S([O-])OO.[K+]>>O=S(=O)(c1ccc2nccc(Cl)c2c1)C1CCOCC1",
        "output": "730"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCOC(=O)c1cn(COCC[Si](C)(C)C)c2ncnc(-c3ccc4cn(C)nc4c3)c12.CC#N.ClCCl.O=C(O)C(F)(F)F.[NH4+].[OH-]>>C=CCOC(=O)c1c[nH]c2ncnc(-c3ccc4cn(C)nc4c3)c12",
        "output": "897"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(Sc1cccc(C(F)(F)F)c1)C1CCCN(C(=O)OC(C)(C)C)C1.CO.O.O=S([O-])OO.[K+]>>CC(C1CCCN(C(=O)OC(C)(C)C)C1)S(=O)(=O)c1cccc(C(F)(F)F)c1",
        "output": "730"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(=O)Cl.CCN(CC)CC.Cl.NC1CCc2cc3c(cc2C1)OCC3.O.c1ccccc1>>CCC(=O)NC1CCc2cc3c(cc2C1)OCC3",
        "output": "45"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C(=O)N1C(=O)O[C@@H](c2ccccc2)[C@H]1C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.Cc1noc(-c2ccc(Br)cc2)c1NC(=O)O[C@H](C)c1ccccc1Cl>>Cc1noc(-c2ccc(-c3ccc(C(C)C(=O)N4C(=O)O[C@@H](c5ccccc5)[C@H]4C)cc3)cc2)c1NC(=O)O[C@H](C)c1ccccc1Cl",
        "output": "933"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC(CN)C1.CCN(CC)CC.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C.ClCCl.F[P-](F)(F)(F)(F)F.O.[Na+].[OH-]>>COc1cc(C(=O)NCC2CN(C(=O)OC(C)(C)C)C2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CS(C)=O.FC(F)(F)Oc1ccc(CBr)cc1.[C-]#N.[Na+]>>N#CCc1ccc(OC(F)(F)F)cc1",
        "output": "39"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)S(=O)(=O)NCC(C)(O)c1ccc(O)cc1.CN(C)C=O.Fc1cc(F)cc(CBr)c1.O.[H-].[I-].[Na+].[Na+]>>CC(C)S(=O)(=O)NCC(C)(O)c1ccc(OCc2cc(F)cc(F)c2)cc1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cc2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(OCc3ccccc3)c2[nH]1.[C].[Pd]>>CCOC(=O)c1cc2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(O)c2[nH]1",
        "output": "264"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC1(C)NC(=O)CCc2cc([N+](=O)[O-])ccc21.CCOC(C)=O.CO.O.O=C([O-])O.O=S([O-])S(=O)[O-].[Cl-].[Na+].[Na+].[Na+].[Na+]>>CC1(C)NC(=O)CCc2cc(N)ccc21",
        "output": "507"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCCCCCCCCN1CCC(C(C)(C)C(N)=O)CC1.COCCO[Al+]OCCOC.Cc1ccccc1.[H-].[H-].[Na+].[Na+].[OH-]>>CCCCCCCCCCCCN1CCC(C(C)(C)CN)CC1",
        "output": "112"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCCC[C@H](N)C(=O)O.O.[Na+].[OH-].c1ccc2[nH]nnc2c1>>CC(C)(C)OC(=O)NCCCC[C@H](N)C(=O)O",
        "output": "631"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)N.CCOC(=O)N1CCC(=O)CC1.CO.[H][H].[Pd].c1ccsc1>>CCOC(=O)N1CCC(NC(C)C)CC1",
        "output": "236"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=Cc1ccc(C(F)(F)F)nc1.CN1CCCC1=O.Cc1ccc2[nH]c3c(c2c1)CN(C)C(C)(C)C3.[K+].[OH-]>>Cc1ccc2c(c1)c1c(n2CCc2ccc(C(F)(F)F)nc2)CC(C)(C)N(C)C1",
        "output": "986"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(N)c1nc2ccc(F)cc2cc1-c1ccccn1.CCCCO.CCN(C(C)C)C(C)C.Clc1ncnc2[nH]cnc12>>CC(Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2cc1-c1ccccn1",
        "output": "145"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Fc1cccc(F)c1.O=CN1CCC(C(=O)Cl)CC1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=CN1CCC(C(=O)c2ccc(F)cc2F)CC1",
        "output": "31"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CC(=O)Nc1ccc(-c2ccccc2)cc1.CO.O.O.[Li]O>>O=C(O)CC(=O)Nc1ccc(-c2ccccc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CNCCN1.Clc1cc(NC2CCCC2)nc(NC2CCCC2)n1>>c1c(NC2CCCC2)nc(NC2CCCC2)nc1N1CCNCC1",
        "output": "162"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.OC1(c2cccc(F)c2)CCN(Cc2ccccc2)CC1.[OH-].[OH-].[Pd+2]>>OC1(c2cccc(F)c2)CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CCOC(C)=O.Cc1ccccc1C.Clc1cnc(Cl)c(Cl)c1.Nc1ccc(Cl)cc1.[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Clc1ccc(Nc2ncc(Cl)cc2Cl)cc1",
        "output": "434"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1cc(C(F)(F)F)cc(S(=O)(=O)N[C@H]2CCC[C@@H](n3cnnc3)C2)c1.CCO.COC(OC)N(C)C>>CN(C)/C=C/C(=O)c1cc(C(F)(F)F)cc(S(=O)(=O)N[C@H]2CCC[C@@H](n3cnnc3)C2)c1",
        "output": "898"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.NC(=O)c1cn(C2CCCC2)c2cc(NC3CCCCC3)c(F)cc2c1=O.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>N#Cc1cn(C2CCCC2)c2cc(NC3CCCCC3)c(F)cc2c1=O",
        "output": "624"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cn([C@H](CO[Si](C)(C)C(C)(C)C)C(C)C)c2nc(OC)c(C)cc2c1=O.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>CCOC(=O)c1cn([C@H](CO[Si](C)(C)C(C)(C)C)C(C)C)c2nc(OC)c(CBr)cc2c1=O",
        "output": "625"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(O)c1cccc(NC(=O)NCC(=O)N(CC(=O)N2CCCc3ccccc32)c2ccccc2)c1.ClCCl.[Mn+4].[O-2].[O-2]>>CC(=O)c1cccc(NC(=O)NCC(=O)N(CC(=O)N2CCCc3ccccc32)c2ccccc2)c1",
        "output": "32"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COc1ccncc1NC(=O)c1c(NC(=O)C(F)(F)F)nn2ccc(CO)nc12.ClCCl.O=S(Cl)Cl>>COc1ccncc1NC(=O)c1c(NC(=O)C(F)(F)F)nn2ccc(CCl)nc12",
        "output": "594"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COCC[C@H]1[C@H](C=O)C[C@@H]2C[C@H]1C2(C)C.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COCC[C@H]1[C@H](CO)C[C@@H]2C[C@H]1C2(C)C",
        "output": "223"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(Br)c(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c1.ClCCl.O.O=C(O)C(F)(F)F.[Na+].[OH-]>>COc1ccc(Br)c(C(=O)N2CCNCC2)c1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc2cc(-c3ccc(-c4ccccc4)n3-c3ccccc3)ccc2c1.Cl.c1ccncc1>>Oc1ccc2cc(-c3ccc(-c4ccccc4)n3-c3ccccc3)ccc2c1",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.COCCl.O.O=C([O-])[O-].Oc1cccc(I)c1.[K+].[K+]>>COCOc1cccc(I)c1",
        "output": "375"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.COc1cccc(C(=O)Nc2ccc(OCCN)c(-c3ccnn3C)c2)c1.ClCCl.O=C(Cl)OCc1ccccc1>>COc1cccc(C(=O)Nc2ccc(OCCNC(=O)OCc3ccccc3)c(-c3ccnn3C)c2)c1",
        "output": "479"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.O=[N+]([O-])c1ccc2c(cnn2Cc2ccccc2)c1.[Fe]>>Nc1ccc2c(cnn2Cc2ccccc2)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccc(O)cc1F>>Nc1ccc(O)cc1F",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOc1c(C=O)cc(Br)c(-c2ccc(F)cc2F)c1F.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].OB(O)C1CC1.[Na+].[Na+].[Pd].[Pd]>>CCOc1c(C=O)cc(C2CC2)c(-c2ccc(F)cc2F)c1F",
        "output": "956"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCC2(CC1)Cc1cc(/C=C/C(=O)O)cnc1NC2=O.Cl.Cl.Cl.On1nnc2cccnc21.c1ccc2oc(C3CNC3)cc2c1>>CN1CCC2(CC1)Cc1cc(/C=C/C(=O)N3CC(c4cc5ccccc5o4)C3)cnc1NC2=O",
        "output": "811"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(CCC#N)Cc1ccc(OCc2ccc(OCc3ccc4ccccc4n3)cc2)cc1.CN(C)C=O.ClC(Cl)Cl.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>CC(CCc1nnn[nH]1)Cc1ccc(OCc2ccc(OCc3ccc4ccccc4n3)cc2)cc1",
        "output": "366"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Clc1ccncc1Br.O.O=C([O-])[O-].OC1CN(c2ccc3ccccc3n2)C1.[Cs+].[Cs+]>>Brc1cnccc1OC1CN(c2ccc3ccccc3n2)C1",
        "output": "651"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)c1cc(C(=O)O)ccn1.Cl.NC1=NS(=O)(=O)Nc2cccc(OCC3(N)CCC3)c21>>CN(C)c1cc(C(=O)NC2(COc3cccc4c3C(N)=NS(=O)(=O)N4)CCC2)ccn1",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)OC(C(C)O)C(O)c1cccc(C(=O)C(C(=O)c2cccc(F)c2)=C2Nc3ccccc3N2)c1.CO.[Cl-].[NH4+].[Na+].[OH-]>>CC(O)C(O)C(O)c1cccc(C(=O)C(C(=O)c2cccc(F)c2)=C2Nc3ccccc3N2)c1",
        "output": "325"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.O=S1(=O)CC(CCO)C1>>Cc1ccc(S(=O)(=O)OCCC2CS(=O)(=O)C2)cc1",
        "output": "197"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.Cc1cc([N+](=O)[O-])cnc1Cl.NC(N)=O.O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=S([O-])S(=O)[O-].OO.[Na+].[Na+]>>Cc1cc([N+](=O)[O-])c[n+]([O-])c1Cl",
        "output": "396"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(=O)CC(=O)C(C)(C)C.CN1CCCC1=O.COc1ccc(C(C)C)cc1Br.O=C([O-])[O-].Oc1ccccc1.[Cl-].[Cs+].[Cs+]>>COc1ccc(C(C)C)cc1Oc1ccccc1",
        "output": "238"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCCCBr.CC#N.COC(=O)c1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(OCCCBr)cc1",
        "output": "385"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2C1CCC(CCO)CC1>>CS(=O)(=O)OCCC1CCC(n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1",
        "output": "0"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc(-c2ccccc2)cc1.O.O=C(Cl)c1ccc(Cl)c(Cl)c1.O=[N+]([O-])c1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>Cc1ccc(-c2ccc(C(=O)c3ccc(Cl)c(Cl)c3)cc2)cc1",
        "output": "61"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CN(C)C=O.O=C(O)c1ccc2[nH]c(=O)oc2c1.O=S(Cl)Cl.[NH4+].[OH-]>>NC(=O)c1ccc2[nH]c(=O)oc2c1",
        "output": "358"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#CCOc1ccc(S(=O)(=O)C2(C(=O)O)CCN(C(=O)c3cccs3)CC2)cc1.CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.Cl.NO.On1nnc2ccccc21>>CC#CCOc1ccc(S(=O)(=O)C2(C(=O)NO)CCN(C(=O)c3cccs3)CC2)cc1",
        "output": "480"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.CI.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>COC(=O)C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "415"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.ClCCl.Cl[Pd]Cl.Cn1c(Cl)ncc(O)c1=O.O.O=C([O-])[O-].OB(O)c1cccc(-c2ccccc2)c1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cn1c(-c2cccc(-c3ccccc3)c2)ncc(O)c1=O",
        "output": "874"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCC.N#CC[C@@H](O)c1ccc(OCC2CCCCC2)s1>>NCC[C@@H](O)c1ccc(OCC2CCCCC2)s1",
        "output": "246"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=S(=O)([O-])[O-].O=[N+]([O-])c1cccc(C(F)C(F)(F)CO)c1.[Na+].[Na+].c1ccncc1>>O=[N+]([O-])c1cccc(C(F)C(F)(F)COS(=O)(=O)C(F)(F)F)c1",
        "output": "582"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.N#Cc1ccccc1-c1ccc(Cn2c(=O)n(CC(=O)c3ccc(F)cc3)c(=O)c3cc(CC(F)(F)F)sc32)cc1.[BH4-].[Na+]>>N#Cc1ccccc1-c1ccc(Cn2c(=O)n(CC(O)c3ccc(F)cc3)c(=O)c3cc(CC(F)(F)F)sc32)cc1",
        "output": "24"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CNC.Cn1cc(S(=O)(=O)Cl)c(=O)c2cc(F)c(Cl)cc21>>CN(C)S(=O)(=O)c1cn(C)c2cc(Cl)c(F)cc2c1=O",
        "output": "169"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)N.Cc1ccc(-c2cc(C(=O)O)nn2-c2cnccn2)nc1>>Cc1ccc(-c2cc(C(=O)NC(C)(C)C)nn2-c2cnccn2)nc1",
        "output": "816"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1CCCC(C)N1N.CCCCCC.CCOC(C)=O.ClC(Cl)Cl.O=Cc1ccc(C=O)cc1>>CC1CCCC(C)N1N=Cc1ccc(C=O)cc1",
        "output": "167"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](N)C1.COc1ccc(C2CC(C(F)(F)F)n3nc(-c4cccc(C(=O)O)c4)cc3N2)cc1OC>>COc1ccc(C2CC(C(F)(F)F)n3nc(-c4cccc(C(=O)N[C@H]5CCN(C(=O)OC(C)(C)C)C5)c4)cc3N2)cc1OC",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)O.Cl.Cl.Clc1ccc(C(c2ccc(Cl)cc2)c2ccc3ncnc(Cl)c3c2)cc1.NC1CCN(c2ncccn2)CC1>>Clc1ccc(C(c2ccc(Cl)cc2)c2ccc3ncnc(NC4CCN(c5ncccn5)CC4)c3c2)cc1",
        "output": "110"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCCC(C(=O)O)C1.CI.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)C1CCCN(C(=O)OC(C)(C)C)C1",
        "output": "415"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "FC(F)(F)c1ccnc(Cl)c1.O=C(O)C(F)(F)F.O=C([O-])[O-].OO.[Na+].[Na+]>>[O-][n+]1ccc(C(F)(F)F)cc1Cl",
        "output": "396"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCOc1cccc(N2CC3(CCCC(C)(CN)C3)OC2=O)c1.N#Cc1cc(F)c([N+](=O)[O-])c(Br)c1.O=C([O-])[O-].[K+].[K+]>>CCOc1cccc(N2CC3(CCCC(C)(CNc4cc(C#N)cc(Br)c4[N+](=O)[O-])C3)OC2=O)c1",
        "output": "572"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1.[Li+].[OH-]>>CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=[N+]([O-])CC(O)c1ccc(F)cc1.[Pd]>>NCC(O)c1ccc(F)cc1",
        "output": "226"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=CC(=O)Nc1ccc(S(=O)(=O)N2CCC(N)CC2)cc1.CCN(C(C)C)C(C)C.O=C(Cl)c1ccccc1>>C=CC(=O)Nc1ccc(S(=O)(=O)N2CCC(NC(=O)c3ccccc3)CC2)cc1",
        "output": "271"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cnn(Cc2ccc3c(c2)N(C)CCC3)c1.CO.[Na+].[OH-]>>CN1CCCc2ccc(Cn3cc(C(=O)O)cn3)cc21",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.COc1cc(C(C)N(C)C)c2c(c1)oc(=O)c1ccccc12.O=C([O-])O.[Na+]>>CC(c1cc(O)cc2oc(=O)c3ccccc3c12)N(C)C",
        "output": "732"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.O.O=C1COCCN1Cc1ccc(-c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)nc1.[Cl-].[NH4+].[Zn]>>Nc1ccc(Oc2ccnc3cc(-c4ccc(CN5CCOCC5=O)cn4)sc23)c(F)c1",
        "output": "335"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCc1nc2ccc(C3=NNC(=O)CC3)cc2n1Cc1ccc(-c2ccccc2C(=O)OC)cc1.CCO.[Na+].[OH-]>>CCCCc1nc2ccc(C3=NNC(=O)CC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "FC(F)(F)c1cnc(N2CCNCC2)c(C2CC2)c1.O=C(O)c1ccc(N2CCCS2(=O)=O)cc1>>O=C(c1ccc(N2CCCS2(=O)=O)cc1)N1CCN(c2ncc(C(F)(F)F)cc2C2CC2)CC1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N1c2ccccc2N(Cc2nn(-c3ccccc3C#N)c3ccccc23)C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)[C@@H]1C.ClCCl.O=C(O)C(F)(F)F>>CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2nn(-c3ccccc3C#N)c3ccccc23)c2ccccc2N(C(C)=O)[C@H]1C",
        "output": "634"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(CC(=O)O)SCc1ccccc1.CCN(CC)CC.ClCCl.O=C(C(Cl)(Cl)Cl)C(Cl)(Cl)Cl.OCCN1CCNCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(CC(=O)N1CCN(CCO)CC1)SCc1ccccc1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(N2CCC(Nc3ncnc4ccc(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)cc34)CC2)cc1.[Cl-].[NH4+]>>NC(=O)c1ccc(N2CCC(Nc3ncnc4ccc(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)cc34)CC2)cc1",
        "output": "358"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.N=C=N.NC1CCCCC1.Nc1ccccc1C(=O)O.On1nnc2ccccc21>>Nc1ccccc1C(=O)NC1CCCCC1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.O.O=C(O)c1cccc(CBr)c1Cl.[C-]#N.[K+]>>N#CCc1cccc(C(=O)O)c1Cl",
        "output": "39"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)C[C@H](N[C@@H](c1ccc(Cl)nc1)C(F)(F)F)C(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.N#CC1(N)CC1.O>>CC(C)C[C@H](N[C@@H](c1ccc(Cl)nc1)C(F)(F)F)C(=O)NC1(C#N)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc(N)cc(OC)c1OC.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)CC1CCC(=O)C1.c1ccncc1>>COc1cc(NC(=O)CC2CCC(=O)C2)cc(OC)c1OC",
        "output": "646"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN1CCOCC1.CCN=C=NCCCN(C)C.CN1C(=O)N(C2CCN(C(=O)OC(C)(C)C)CC2)CC1C(=O)O.COC(=O)C1CN(C)C(=O)N1C.Cl.ClCCl.NCc1cccc(C(F)(F)F)c1Cl.O.On1nnc2ccccc21>>CN1C(=O)N(C2CCN(C(=O)OC(C)(C)C)CC2)CC1C(=O)NCc1cccc(C(F)(F)F)c1Cl",
        "output": "797"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Brc1cccc2c1C[C@H](N(Cc1ccccc1)Cc1ccccc1)CC2.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>Cn1cc(-c2cccc3c2C[C@H](N(Cc2ccccc2)Cc2ccccc2)CC3)cn1",
        "output": "971"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)O.CNCCO.COc1nc(OC)nc([N+]2(C)CCOCC2)n1.Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1Oc1ccc(C(=O)O)cc1.[Cl-]>>Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1Oc1ccc(C(=O)N(C)CCO)cc1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCC(=O)N[C@@H](CCCCNC(=O)C/C=C/c1cccnc1)C(=O)OC.Cl.[Na+].[OH-]>>CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCC(=O)N[C@@H](CCCCNC(=O)C/C=C/c1cccnc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O=C(O)Cc1c[nH]cn1.[Na]>>COC(=O)Cc1c[nH]cn1",
        "output": "17"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)CCNC(=O)c1ccc2c(=O)[nH]c3nccc(Cl)c3c2c1.Nc1ccc(NC(=O)c2ccc(F)c(F)c2)cc1>>CN(C)CCNC(=O)c1ccc2c(=O)[nH]c3nccc(Nc4ccc(NC(=O)c5ccc(F)c(F)c5)cc4)c3c2c1",
        "output": "922"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(C)=O.O.O=C(O)CCC(=O)c1ccc(F)cc1.O=C([O-])[O-].Sc1ccccc1.[K+].[K+]>>O=C(O)CCC(=O)c1ccc(Sc2ccccc2)cc1",
        "output": "675"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cccc(S(C)(=O)=O)c1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CS(=O)(=O)c1cccc(CO)c1",
        "output": "444"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCn1c(=O)c(NC(=O)Nc2c(C(C)C)cccc2C(C)C)c(-c2cccc(OCCCN3C(=O)c4ccccc4C3=O)c2)c2cccnc21.CCO.NN.O>>CCCCn1c(=O)c(NC(=O)Nc2c(C(C)C)cccc2C(C)C)c(-c2cccc(OCCCN)c2)c2cccnc21",
        "output": "242"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl.NCc1ccccc1Cl.O=C(O)c1cnc2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc2c1.On1nnc2ccccc21>>O=C(NCc1ccccc1Cl)c1cnc2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc2c1",
        "output": "790"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCS(=O)(=O)N1CCC(C#N)(CC2CCCO2)CC1.CO.N.O.[Ni]>>CCS(=O)(=O)N1CCC(CN)(CC2CCCO2)CC1",
        "output": "246"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)C[AlH]CC(C)C.COC(=O)CCC1CCc2cc(O)ccc2C1>>OCCCC1CCc2cc(O)ccc2C1",
        "output": "343"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1nn(C(C)C)c2cc(-c3ccc(OCc4c(C5CC5)nnn4-c4c(Cl)cccc4Cl)cc3C)ccc12.Cl.O.[Li+].[OH-]>>Cc1cc(OCc2c(C3CC3)nnn2-c2c(Cl)cccc2Cl)ccc1-c1ccc2c(C(=O)O)nn(C(C)C)c2c1",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNC1.CCN(C(C)C)C(C)C.CCOc1ccc(Cc2nc3cc(C(=O)O)ccc3n2CC2CC2)nc1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F>>CCOc1ccc(Cc2nc3cc(C(=O)N4CCCC4)ccc3n2CC2CC2)nc1",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(O)cc12.O.[Na+].[OH-]>>Cc1c(C(=O)O)c2cc(O)ccc2n1Cc1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)[O-].Nc1ccncc1.O=[N+]([O-])c1ccc(F)cc1F.[Cl-].[K+].[NH4+]>>O=[N+]([O-])c1ccc(F)cc1Nc1ccncc1",
        "output": "609"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)CCCNC(=O)OCc1cccc(NC(=O)NC2C(=O)N(CC(=O)N3CCCC3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1.O.O.[Li+].[OH-]>>O=C(O)CCCNC(=O)OCc1cccc(NC(=O)NC2C(=O)N(CC(=O)N3CCCC3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Oc1ccccc1C(=O)O.Cc1nc(N)sc1CCO[N+](=O)[O-]>>CC(=O)Oc1ccccc1C(=O)Nc1nc(C)c(CCO[N+](=O)[O-])s1",
        "output": "918"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1c(C(=O)O)cnn1-c1ccc(F)cc1.N#Cc1cc(N)ccc1N1CCCC1>>Cc1c(C(=O)Nc2ccc(N3CCCC3)c(C#N)c2)cnn1-c1ccc(F)cc1",
        "output": "851"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#C[Si](C)(C)C.CCN(CC)CC.CN(C)C=O.COC(=O)Cc1ccc(C(F)(F)F)cc1Br.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.F[B-](F)(F)F.[Cu]I>>COC(=O)Cc1ccc(C(F)(F)F)cc1C#C[Si](C)(C)C",
        "output": "671"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.COC(=O)c1ccc(-c2cnc(N)c(-c3nc4ccccc4s3)c2)cc1.COC(=O)c1cccc(-c2cnc(N)c(-c3nc4ccccc4s3)c2)c1.O.O=C([O-])[O-].[K+].[K+]>>Nc1ncc(-c2ccc(C(=O)O)cc2)cc1-c1nc2ccccc2s1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CSc1ccc([Mg]Br)cc1.O=Cc1ccccc1OCc1ccccc1.[Cl-].[NH4+]>>CSc1ccc(C(O)c2ccccc2OCc2ccccc2)cc1",
        "output": "309"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.NCCN1CCOCC1.O.O=C(O)CCc1c(C=C2C(=O)Nc3ccccc32)[nH]c2c1CCCC2.O=C(n1ccnc1)n1ccnc1>>O=C(CCc1c(C=C2C(=O)Nc3ccccc32)[nH]c2c1CCCC2)NCCN1CCOCC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CCNC3)cc1.Cn1cc(Br)ccc1=O>>CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CCN(c2ccc(=O)n(C)c2)C3)cc1",
        "output": "597"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)Oc1ccc(Br)cc1-c1cc(Cl)nc(N)n1.Nc1ccc(Cl)cc1>>CC(C)Oc1ccc(Br)cc1-c1cc(Nc2ccc(Cl)cc2)nc(N)n1",
        "output": "161"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COCOc1ccc(Br)cc1N(C)C.Cc1cc(O[Si](C(C)C)(C(C)C)C(C)C)cc(C)c1C=O.[Li]CCCC>>COCOc1ccc(C(O)c2c(C)cc(O[Si](C(C)C)(C(C)C)C(C)C)cc2C)cc1N(C)C",
        "output": "379"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)N(C)c1ccc(N)cc1.O=C(Cl)OCC(Cl)(Cl)Cl.c1ccncc1>>CC(=O)N(C)c1ccc(NC(=O)OCC(Cl)(Cl)Cl)cc1",
        "output": "102"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.O.O=C([O-])[O-].O=Cc1ccccc1O.O=[N+]([O-])c1ccc(F)cc1.[K+].[K+]>>O=Cc1ccccc1Oc1ccc([N+](=O)[O-])cc1",
        "output": "564"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCSc1nc2nc(CO)ccc2c(=O)n1-c1ccc(OCC(F)(F)F)cc1.CS(C)=O.O>>CCSc1nc2nc(C=O)ccc2c(=O)n1-c1ccc(OCC(F)(F)F)cc1",
        "output": "263"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)NCC1CN(c2ccc3c(c2)CCNCC3)C(=O)O1.O=C(O)c1cn(C2CC2)c2c(F)c(F)c(F)cc2c1=O>>CC(=O)NCC1CN(c2ccc3c(c2)CCN(c2c(F)cc4c(=O)c(C(=O)O)cn(C5CC5)c4c2F)CC3)C(=O)O1",
        "output": "676"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(C(=O)Cl)cc1.Nc1ccc(F)c([N+](=O)[O-])c1.O=C(Cl)c1cccs1>>COc1ccc(C(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1",
        "output": "11"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCBr.CCC1(CO)COC1.CCCC[N+](CCCC)(CCCC)CCCC.ClCCl.O.[Br-].[K+].[OH-]>>C=CCOCC1(CC)COC1",
        "output": "120"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O=C1NCCCN1N1CCN(Cc2ccccc2)CC1.[OH-].[OH-].[Pd+2]>>O=C1NCCCN1N1CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.COc1ccc2c(c1)OCCO2.ClP(Cl)Cl.[Na+].[OH-]>>COc1cc2c(cc1C=O)OCCO2",
        "output": "239"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Cc1nc2ccc(CN)cc2c(=O)n1C1CCC(=O)NC1=O.Cl.O=C(O)Cc1ccc(Cl)cc1.O=C(n1ccnc1)n1ccnc1>>Cc1nc2ccc(CNC(=O)Cc3ccc(Cl)cc3)cc2c(=O)n1C1CCC(=O)NC1=O",
        "output": "599"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CNC[C@H](CO[Si](C)(C)C(C)(C)C)C1.O=[N+]([O-])c1cnccc1Cl>>CC(C)(C)OC(=O)N[C@H]1C[C@@H](CO[Si](C)(C)C(C)(C)C)CN(c2ccncc2[N+](=O)[O-])C1",
        "output": "398"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)C1CCC(N)CC1.CS(C)=O.O=C(Nc1cccc2ccc(O)cc12)Oc1ccccc1>>CC(C)(C)C1CCC(NC(=O)Nc2cccc3ccc(O)cc23)CC1",
        "output": "488"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNC.F[P-](F)(F)(F)(F)F.O=C(O)C1CN(c2ccc(C3=NOC(c4cc(Cl)c(Cl)c(Cl)c4)(C(F)(F)F)C3)cc2)C1>>CN(C)C(=O)C1CN(c2ccc(C3=NOC(c4cc(Cl)c(Cl)c(Cl)c4)(C(F)(F)F)C3)cc2)C1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN.COC(=O)[C@@H](C)Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc4nccs4)c3)c12>>CNC(=O)[C@@H](C)Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc4nccs4)c3)c12",
        "output": "392"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C[C@@H](NS(C)(=O)=O)c1ccc(-c2c(Cl)cc(N)cc2C(F)(F)F)cc1.Cl.ClCCl.O.O=C([O-])[O-].S=C(Cl)Cl.[Ca+2]>>C[C@@H](NS(C)(=O)=O)c1ccc(-c2c(Cl)cc(N=C=S)cc2C(F)(F)F)cc1",
        "output": "114"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CCBr.CC(C)(C)[O-].CS(C)=O.OCCc1ccc(OCc2ccccc2)cc1.[K+]>>C=CCOCCc1ccc(OCc2ccccc2)cc1",
        "output": "120"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N(CCOc1cc(Cl)cc(C(=O)O)c1)c1ccncc1.CC1(C)OCC(COCCNc2ccccc2F)O1.CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)c1ccncc1.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)N(CCOc1cc(Cl)cc(C(=O)N(CCOCC2COC(C)(C)O2)c2ccccc2F)c1)c1ccncc1",
        "output": "873"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cc1ccccc1.O.O=C(O)Cc1ccc(CBr)cc1.O=C([O-])O.O=S(Cl)Cl.[Na+]>>COC(=O)Cc1ccc(CBr)cc1",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.C1COCCN1.COc1ccc2[nH]c(C)c(CC(=O)O)c2c1>>COc1ccc2[nH]c(C)c(CC(=O)N3CCOCC3)c2c1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.COc1cccc2c1CC[C@H]1[C@@H]2CCN1CCCCC1CCCCC1.[Na+].[OH-]>>Oc1cccc2c1CC[C@H]1[C@@H]2CCN1CCCCC1CCCCC1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCOCC1.COc1cnc(N2CCOCC2)c2sc(N)nc12.F[P-](F)(F)(F)(F)F.O=C(O)c1ccncc1>>COc1cnc(N2CCOCC2)c2sc(NC(=O)c3ccncc3)nc12",
        "output": "918"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CC1(C)c2ccccc2-c2ccc(Br)cc21.CC1(C)c2ccccc2-c2ccc(N)cc21.Cc1ccccc1.[Fe+2].[Na+].[Pd+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)c2ccccc2-c2ccc(Nc3ccc4c(c3)C(C)(C)c3ccccc3-4)cc21",
        "output": "405"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)O.CC1(CCCCOCc2ccccc2)CCCC2(CO1)OCCO2.N.[Na]>>CC1(CCCCO)CCCC2(CO1)OCCO2",
        "output": "178"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.CCN(CC)CC.ClCCl.Nc1ccccc1.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>>CC(C)(C)OC(=O)N1CCC(C(=O)Nc2ccccc2)CC1",
        "output": "365"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[O-].COCc1onc(-c2ccc(F)cc2)c1-c1ccnc(Br)c1.Cc1ccccc1.NC1CCCCC1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COCc1onc(-c2ccc(F)cc2)c1-c1ccnc(NC2CCCCC2)c1",
        "output": "715"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.O.O=C(Cl)c1ccc(F)cc1C(F)(F)F.O=C([O-])[O-].[K+].[K+].c1cnc2c(c1)CNc1ccccc1N2>>O=C(c1ccc(F)cc1C(F)(F)F)N1Cc2cccnc2Nc2ccccc21",
        "output": "614"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.ClCCCl.ClCCl.N[C@H]1CCCC[C@H]1N1CC[C@@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C1.O=C(O)c1ccccc1.On1nnc2ccccc21>>O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@@H]2CCCC[C@@H]2NC(=O)c2ccccc2)C1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cc(OCC(C)(N)C#N)c(Cl)c2c1COB2O.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(OC(F)(F)F)cc1>>COc1cc(OCC(C)(C#N)NC(=O)c2ccc(OC(F)(F)F)cc2)c(Cl)c2c1COB2O",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCOCCOCCOCCOCCO1.CC(C)(C)OC(=O)Nc1ccc(O)cc1.CN(C)C=O.N#Cc1cc(Cl)ccc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)Nc1ccc(Oc2ccc([N+](=O)[O-])c(C#N)c2)cc1",
        "output": "299"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClCCl.O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](N2CCNCC2)[C@H](c2ccccc2)C1>>CC(=O)N1CCN([C@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@H]2c2ccccc2)CC1",
        "output": "125"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#CCCCCC(=O)c1ncc(-c2ccccn2)o1.O=[N+]([O-])c1ccc(I)cc1>>O=C(CCCCC#Cc1ccc([N+](=O)[O-])cc1)c1ncc(-c2ccccn2)o1",
        "output": "664"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.O=C(O)C1(c2ccc([N+](=O)[O-])cc2)CC1.[Pd]>>Nc1ccc(C2(C(=O)O)CC2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCNCC.COCCc1nc2c(N)nc3ccccc3c2n1CCCN(Cc1ccccc1OCC(=O)OC)C(=O)CCl.Cl>>CCN(CC)CC(=O)N(CCCn1c(CCOC)nc2c(N)nc3ccccc3c21)Cc1ccccc1OCC(=O)OC",
        "output": "340"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.COCCOc1cc(F)ccc1N.O=C([O-])Cc1nc(N2CCOCC2)cc(=O)[nH]1.[Na+].c1ccncc1>>COCCOc1cc(F)ccc1NC(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1",
        "output": "891"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=CNCC1(c2ccc(Br)cc2)CCCCC1.OB(O)c1ccc(F)cc1>>O=CNCC1(c2ccc(-c3ccc(F)cc3)cc2)CCCCC1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1CCCC(C(=O)O)C1.O.[Na+].[OH-]>>CC(C)(C)OC(=O)NC1CCCC(C(=O)O)C1",
        "output": "631"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC(CCO)C1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.ClCCl.Oc1ccc(Br)cc1C(F)(F)F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CC(CCOc2ccc(Br)cc2C(F)(F)F)C1",
        "output": "550"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(CF)n1.Cl.[Na+].[OH-]>>Nc1cccc(CF)n1",
        "output": "885"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)Cc1ccc(C#N)c(F)c1Cl.O=C([O-])[O-].[K+].[K+]>>COC(=O)Cc1ccc(C#N)c(OC)c1Cl",
        "output": "485"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=Cc1ccc(CO)cn1.Cc1cc(-c2nnc3c4ccccc4c(Cl)nn23)no1>>C=Cc1ccc(COc2nn3c(-c4cc(C)on4)nnc3c3ccccc23)cn1",
        "output": "407"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNCCCS(=O)(=O)CCCC(F)(F)F.Oc1ccc2c(c1)CCCC(c1ccccc1)=C2CCCCCCBr>>CN(CCCCCCC1=C(c2ccccc2)CCCc2cc(O)ccc21)CCCS(=O)(=O)CCCC(F)(F)F",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCNc1ccc(OC)c(Cl)c1Cl.ClC(Cl)C(Cl)Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>CCCCNc1ccc(O)c(Cl)c1Cl",
        "output": "402"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cl.O.O=c1cc(C=Cc2ccc([N+](=O)[O-])cc2)oc(-c2ccccc2)c1.[Fe]>>Nc1ccc(C=Cc2cc(=O)cc(-c3ccccc3)o2)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC.CCO.Cl.O.O=Cc1cc(F)c(F)c(F)c1.[BH4-].[Na+]>>OCc1cc(F)c(F)c(F)c1",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1CC(C(=O)O)CCC1=O.Cc1ccccc1[C@H]1[C@@H]2CNC[C@H]2CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>Cc1ccccc1[C@H]1[C@@H]2CN(C(=O)C3CCC(=O)N(C)C3)C[C@H]2CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O=C(O)c1ccc(CBr)c(C(F)(F)F)c1.O=C([O-])[O-].O=S(=O)(O)O.[Na+].[Na+]>>CCOC(=O)c1ccc(CBr)c(C(F)(F)F)c1",
        "output": "33"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CC(=O)[O-].COCCOC.Cc1cc(Br)cc(C)c1-n1ccnc1-c1ccc(F)cc1.Cc1cc(C)cc(B(O)O)c1.O.O=C([O-])[O-].[K+].[K+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(C)cc(-c2cc(C)c(-n3ccnc3-c3ccc(F)cc3)c(C)c2)c1",
        "output": "837"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccccc1.Cc1cc(C(=O)Cl)ccc1Br.O.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(C(=O)c2ccc(Br)c(C)c2)cc1",
        "output": "61"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.O=C(O)Cc1ccccc1Cl.O=S(=O)(O)O>>CCOC(=O)Cc1ccccc1Cl",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C(O)c1c(C(F)(F)F)nc2cc(C(F)(F)F)ccc2c1O.O=S(Cl)Cl.c1ccccc1>>O=C(Cl)c1c(C(F)(F)F)nc2cc(C(F)(F)F)ccc2c1O",
        "output": "188"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.ClCCl.O=C(O)CN1CCCC1=O.Oc1cc(Cl)c(Cl)cc1Cl>>O=C(CN1CCCC1=O)Oc1cc(Cl)c(Cl)cc1Cl",
        "output": "108"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@H](CC(=O)OCc1ccccc1)C(=O)O.CCN(CC)CC.CCOC(=O)Cl.CNC.Cl.ClCCl>>CN(C)C(=O)[C@@H](CC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CC(C(=O)NC1CC1)c1ccc(C2CCNCC2)cc1.N#Cc1cc(OCC2CC2)ccc1F.O=C([O-])[O-].[K+].[K+]>>CC(C(=O)NC1CC1)c1ccc(C2CCN(c3ccc(OCC4CC4)cc3C#N)CC2)cc1",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(C)=O.CSCC(C)(C)[C@H](C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(C3CC3)nc12.O.O=S([O-])OO.[K+]>>C[C@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(C3CC3)nc12)C(C)(C)CS(C)(=O)=O",
        "output": "847"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(CO)c(Cl)c1.ClCCl.O=S(Cl)Cl>>Cc1ccc(CCl)c(Cl)c1",
        "output": "81"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCO.COc1ccc(C(=O)c2cc(OC)c(OC)cc2[N+](=O)[O-])cc1OC.[H][H].[Pt]>>COc1ccc(C(=O)c2cc(OC)c(OC)cc2N)cc1OC",
        "output": "202"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "NC1CCCCC1.O=C(O)c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1>>O=C(NC1CCCCC1)c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CCN1CCN(C(=O)N2CCC3(CC2)CCN(c2ccncc2)C3)CC1=O.Cl>>O=C(O)CCN1CCN(C(=O)N2CCC3(CC2)CCN(c2ccncc2)C3)CC1=O",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)CC(=O)Cl.CC(C)(C)CC(=O)N1CCC(OC(c2ccc(Cl)cc2)c2ccccc2Cl)CC1.Cc1ccccc1C(OC1CCNCC1)c1ccccc1>>Cc1ccccc1C(OC1CCN(C(=O)CC(C)(C)C)CC1)c1ccccc1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COc1c(Br)cccc1CN1C(=O)c2ccccc2C1=O.NN.O>>COc1c(Br)cccc1CN",
        "output": "418"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CO.C[C@@H](O)[C@H](N)C(=O)O.O=S(Cl)Cl>>COC(=O)[C@@H](N)[C@@H](C)O",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[O-].CC(C)C1=CC(C(C)C)=C(c2ccccc2)C(C(C)C)(P(C2CCCCC2)C2CCCCC2)C1.Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Cl.Cc1ccccc1.Nc1cc(N2CCOCC2)cnc1F.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)cnc1F",
        "output": "859"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)CSCc1ccco1.Cl.O.[H-].[K+]>>O=C(O)CSCc1ccco1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCO.CCc1nn(Cc2ccc(-c3ccccc3C#N)cc2)c(=N)s1.ClC(Cl)Cl.O=S(=O)(O)O.[Cl-].[Cl-].[N-]=[N+]=[N-].[Na+].[Zn+2]>>CCc1nn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c(=N)s1",
        "output": "390"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.Nc1ccc(F)c(Cl)c1.O=Cc1ccnc(-c2cccnc2)c1O>>Oc1c(C=Nc2ccc(F)c(Cl)c2)ccnc1-c1cccnc1",
        "output": "329"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN.ClCCl.O=C(Cl)c1cc([N+](=O)[O-])ccc1Cl>>CCNC(=O)c1cc([N+](=O)[O-])ccc1Cl",
        "output": "271"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.Nc1cc(C(=O)O)ccc1F.c1ccc2c(c1)CC[C@@H]1NCCC[C@H]21>>Nc1cc(C(=O)N2CCC[C@@H]3c4ccccc4CC[C@@H]32)ccc1F",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC[C@@H]1C(=O)N(C)c2cc(F)ccc2N1C(=O)c1ccc(O)cc1.CC[C@H]1C(=O)N(CC)c2ccc(F)cc2N1C(=O)c1ccc(OC)cc1>>CC[C@H]1C(=O)N(CC)c2ccc(F)cc2N1C(=O)c1ccc(O)cc1",
        "output": "786"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(C)=O.COc1ccc(O)c(C(C)(C)C)c1.ClCC1CO1.O=C([O-])[O-].[K+].[K+]>>COc1ccc(OCC2CO2)c(C(C)(C)C)c1",
        "output": "15"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1c(CCCl)sc2c1CCN(C(C)=O)C2.CN(C)C=O.Cc1ccccc1.Cl.Fc1ccc2c(C3CCNCC3)nsc2c1.O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CCc1c(CCN2CCC(c3nsc4cc(F)ccc34)CC2)sc2c1CCN(C(C)=O)C2",
        "output": "138"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.COc1cc(-c2ccc(Cn3ncc4cc(C(C)(C)C)cc(F)c4c3=O)cc2CO)ccn1.C[Si](C)(C)Cl.[I-].[Na+]>>CC(C)(C)c1cc(F)c2c(=O)n(Cc3ccc(-c4cc[nH]c(=O)c4)c(CO)c3)ncc2c1",
        "output": "758"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.CC(=O)Nc1cccc2c1CC(=O)CC2.CC(=O)O.CN(C)C=O.Cc1ccc(S(=O)(=O)O)cc1.[BH3-]C#N.[Na+].c1ccccc1>>CC(=O)Nc1cccc2c1CC(N1CCCC1)CC2",
        "output": "187"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)OC(=O)Nc2ccc(OCCCCSc3ccc(C4CCCCC4)cc3)cc21.OO>>CC1(C)OC(=O)Nc2ccc(OCCCCS(=O)c3ccc(C4CCCCC4)cc3)cc21",
        "output": "199"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1nnc(C(N)C2(C)COC2)o1.O=C(O)c1cc(OCC(F)(F)F)c(C2CC2)cn1>>Cc1nnc(C(NC(=O)c2cc(OCC(F)(F)F)c(C3CC3)cn2)C2(C)COC2)o1",
        "output": "137"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)NS(=O)(=O)c1cc(N)cc(CCc2cccc(NC(=O)OC(C)(C)C)c2)c1.Clc1ncc(Br)c(Cl)n1>>CC(C)(C)NS(=O)(=O)c1cc(CCc2cccc(NC(=O)OC(C)(C)C)c2)cc(Nc2nc(Cl)ncc2Br)c1",
        "output": "352"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1cc[nH]n1.C1CCOC1.CC(C)(C)[O-].CCOC(C)=O.CN(C)C=O.CS(=O)(=O)CCCl.[K+]>>CS(=O)(=O)CCn1ccc(Br)n1",
        "output": "604"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCOc1cc(OC2CCOCC2)c2c(Cl)ncnc2c1.Nc1c(Cl)cnc2c1OCO2>>ClCCOc1cc(OC2CCOCC2)c2c(Nc3c(Cl)cnc4c3OCO4)ncnc2c1",
        "output": "161"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1ccc(C)c(F)c1.ClCCl>>Cc1ccc(O)cc1F",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNC1.CCN(C(C)C)C(C)C.CN(C)C=O.O=C1c2c(-c3ccccc3)noc2CCC1CCCCl.[I-].[Na+]>>O=C1c2c(-c3ccccc3)noc2CCC1CCCN1CCCC1",
        "output": "138"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCc1cccc(C)c1CNc1cc(Cl)nc2c1nc(C)n2C.CO.[Pd]>>CCc1cccc(C)c1CNc1ccnc2c1nc(C)n2C",
        "output": "40"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCl.Nc1ccc(NC(=O)Nc2ccccc2)nc1.O=S(=O)(Cl)c1cccc(-c2ccc(F)cc2)c1.c1ccncc1>>O=C(Nc1ccccc1)Nc1ccc(NS(=O)(=O)c2cccc(-c3ccc(F)cc3)c2)cn1",
        "output": "554"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC[SiH](CC)CC.ClCCl.O=C(O)C(F)(F)F.O=C1CCc2c(Br)cccc21.[Cl-].[NH4+]>>Brc1cccc2c1CCC2",
        "output": "92"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)Cc1nccn1CCCCc1ccc(O)cc1.ClCc1coc(/C=C/c2ccc(Cl)cc2)n1.[H-].[Na+]>>CS(=O)(=O)Cc1nccn1CCCCc1ccc(OCc2coc(/C=C/c3ccc(Cl)cc3)n2)cc1",
        "output": "760"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C1C2Cc3cc(OCc4cc(-c5cnc(OCCC(C)(C)O)cc5C(F)(F)F)ccc4F)ncc3C21.CO.Cl.O.[Na+].[OH-]>>CC(C)(O)CCOc1cc(C(F)(F)F)c(-c2ccc(F)c(COc3cc4c(cn3)C3C(C4)C3C(=O)O)c2)cn1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(NC(=O)c2ccccc2)cc1N.ClCCl.O=C(Cl)c1cccc(CCl)c1>>Cc1ccc(NC(=O)c2ccccc2)cc1NC(=O)c1cccc(CCl)c1",
        "output": "11"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)N.O=C(O)Cc1ccc(S(=O)(=O)Cl)cc1>>CC(C)NS(=O)(=O)c1ccc(CC(=O)O)cc1",
        "output": "43"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCC1CC1.CC#N.CC(C)(C)c1ccc(CN(CCc2cccc(O)c2)C(=O)c2cc(Cl)cc3cc[nH]c23)cc1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)c1ccc(CN(CCc2cccc(OCC3CC3)c2)C(=O)c2cc(Cl)cc3cc[nH]c23)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1ccc(-c2cccc(C3Nc4ccc(F)c(C(=O)O)c4CC3(C)C)c2)cc1.CN(C)C=O.CS(N)(=O)=O.O=C(n1ccnc1)n1ccnc1.[H-].[Na+]>>CC(C)(C)c1ccc(-c2cccc(C3Nc4ccc(F)c(C(=O)NS(C)(=O)=O)c4CC3(C)C)c2)cc1",
        "output": "580"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc2c(Nc3ccc(C)cc3F)ncnc2cc1OCC1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>COc1cc2c(Nc3ccc(C)cc3F)ncnc2cc1OCC1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)C1CCC(O[Si](C)(C)C(C)(C)C)CC1.[Na+].[OH-]>>CC(C)(C)[Si](C)(C)OC1CCC(C(=O)O)CC1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC[C@@](C)(NC(=O)OC(C)(C)C)C(=O)Nc1ccc(Oc2cccc3c2C2CC2CO3)nc1.ClCCl.O=C(O)C(F)(F)F>>CC[C@@](C)(N)C(=O)Nc1ccc(Oc2cccc3c2C2CC2CO3)nc1",
        "output": "431"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)NC(C)C.Fc1ccccc1Br.O=C=O.[Li].[Li]CCCC>>O=C(O)c1cccc(Br)c1F",
        "output": "387"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CNCCOC.Clc1ccc(-c2nsc3cc(OCCCCBr)ccc23)cc1>>COCCN(C)CCCCOc1ccc2c(-c3ccc(Cl)cc3)nsc2c1",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.Cl.O=C(CCCCl)c1ccccc1.[BH4-].[Na+]>>OC(CCCCl)c1ccccc1",
        "output": "24"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.ClCCl.NCCCCOc1ccc(Br)cc1.O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc21>>O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc21)NCCCCOc1ccc(Br)cc1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)c1cccc(OCCCCCCl)c1.O=C(Nc1cccc(C2CCNCC2)c1)C1CC1>>CC(=O)c1cccc(OCCCCCN2CCC(c3cccc(NC(=O)C4CC4)c3)CC2)c1",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C[C@@]12C[C@@H]3CC[C@@H]4CC(=O)CC[C@@H]4[C@H]3C[C@H]1CCC2=O.Cl>>C[C@@]12C[C@@H]3CC[C@@H]4CC(O)CC[C@@H]4[C@H]3C[C@H]1CCC2=O",
        "output": "91"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CCCCCCC(C)N.CCN(CC)CC.CCOC(C)=O>>CCCCCCC(C)NC(C)=O",
        "output": "45"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#CC1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1.CC(C)NC(C)C.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Ic1ccccc1.[Cu]I>>CC(C)(CCCN1CCCC(C#Cc2ccccc2)C1)S(=O)(=O)c1ccccc1",
        "output": "664"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCS.CN(C)C=O.Fc1ccc(-c2nc3n(c2-c2ccncc2)CCC3)cc1.[H-].[Na+]>>CCSc1ccc(-c2nc3n(c2-c2ccncc2)CCC3)cc1",
        "output": "503"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCc1c(NC(N)=O)c2c(OCC(=O)OC(C)(C)C)cccc2n1Cc1ccccc1-c1ccc(F)cc1.O=C(O)C(F)(F)F>>CCc1c(NC(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1-c1ccc(F)cc1",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C=O.CN1CCC(N)CC1.ClCCCl.NC(=O)c1ccc(-c2ccccc2F)c2c1[nH]c1cc(C(=O)O)ccc12.On1nnc2ccccc21>>CN1CCC(NC(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)ccc(-c4ccccc4F)c23)CC1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOCC.COC(=O)C1(c2ccccc2)CCNCC1.Cl.ClCCl.O=C(Cl)OC1C2CC3CC(C2)CC1C3>>COC(=O)C1(c2ccccc2)CCN(C(=O)OC2C3CC4CC(C3)CC2C4)CC1",
        "output": "219"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CNc1ncc(-c2nc(N3CCOCC3)c3nc(Cl)n(CC4CCOC4)c3n2)cn1.CS(C)=O.C[C@H]1CNC[C@@H](C)N1>>CNc1ncc(-c2nc(N3CCOCC3)c3nc(N4C[C@H](C)N[C@H](C)C4)n(CC4CCOC4)c3n2)cn1",
        "output": "214"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)C1CCNCC1.CCN(CC)CC.Cl.ClCCl.O.O=C(Cl)OCc1ccccc1>>CC(=O)C1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "427"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "NC1CCC(CO)CC1.O=C(O)c1ccncc1>>O=C(NC1CCC(CO)CC1)c1ccncc1",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)Nc1nc(/C(=N/OC2(C(=O)OC(c3ccccc3)c3ccccc3)CC2)C(=O)O)cs1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.ClCCl.ClCCl.F[P-](F)(F)(F)(F)F.N[C@@H]1C(=O)N[C@@H]1Cn1cncn1>>CC(C)(C)OC(=O)Nc1nc(/C(=N/OC2(C(=O)OC(c3ccccc3)c3ccccc3)CC2)C(=O)N[C@@H]2C(=O)N[C@@H]2Cn2cncn2)cs1",
        "output": "587"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Cl.CCN(CC)CC.Cc1nc(N)ccc1Br.ClCCl>>CC(=O)Nc1ccc(Br)c(C)n1",
        "output": "332"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1ccccc1Cc1ccc(Br)cc1.Cc1nc(CC2CCNCC2)nc(C(=O)NCC(=O)OC(C)(C)C)c1OCc1ccccc1.Cl>>CCOC(=O)c1ccccc1Cc1ccc(N2CCC(Cc3nc(C)c(OCc4ccccc4)c(C(=O)NCC(=O)OC(C)(C)C)n3)CC2)cc1",
        "output": "294"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1scc(CCN)c1Cl.O>>COC(=O)c1scc(CCNC(=O)OC(C)(C)C)c1Cl",
        "output": "631"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(=O)N1CCN(C(=O)C(N)Cc2c[nH]cn2)CC1.CO.COc1cc(C(=O)O)nc2ccccc12.ClCCl.On1nnc2ccccc21>>CCOC(=O)N1CCN(C(=O)C(Cc2c[nH]cn2)NC(=O)c2cc(OC)c3ccccc3n2)CC1",
        "output": "738"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)CCCCCOc1ccccc1CN(C(=O)c1ccc(-c2ccco2)nc1)C(C)C.CO.O.O.[Li+].[OH-]>>CC(C)N(Cc1ccccc1OCCCCCC(=O)O)C(=O)c1ccc(-c2ccco2)nc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.COc1cc(-c2cnc(N)c(-c3nc4cccnc4o3)c2)ccc1O.ClCCl.OCCN1CCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc(-c2cnc(N)c(-c3nc4cccnc4o3)c2)ccc1OCCN1CCCC1",
        "output": "478"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc(N2CCC(Oc3ccc(I)cc3)C2=O)ccc1OCCSC.OB(O)c1ccccc1F>>COc1cc(N2CCC(Oc3ccc(-c4ccccc4F)cc3)C2=O)ccc1OCCSC",
        "output": "855"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1c(F)cccc1CCl.OCCCCl>>COc1c(F)cccc1COCCCCl",
        "output": "208"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#C[C@]1(O)CCN(C)C1=O.CCOC(=O)c1nc2c(s1)C(O)(C(C)C)COc1cc(F)c(Br)cc1-2>>CCOC(=O)c1nc2c(s1)C(O)(C(C)C)COc1cc(F)c(C#C[C@]3(O)CCN(C)C3=O)cc1-2",
        "output": "659"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CCN(C(C)C)C(C)C.CO.ClCCl.Cn1nnc2c(C#N)nc(-c3ccc(OCCC4CCNCC4)c(C(F)(F)F)c3)cc21>>CC(=O)N1CCC(CCOc2ccc(-c3cc4c(nnn4C)c(C#N)n3)cc2C(F)(F)F)CC1",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.CCn1c(=O)c2c(nc(/C=C/c3ccc(OC)c(OC)c3)n2C)n(CC)c1=O.CO.ClCCl>>CCn1c(=O)c2c(nc(/C=C/c3ccc(O)c(O)c3)n2C)n(CC)c1=O",
        "output": "19"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCO.Cc1cn(-c2cc(C(F)(F)F)cc(Cl)c2[N+](=O)[O-])cn1.[Fe].[Na+].[OH-]>>Cc1cn(-c2cc(C(F)(F)F)cc(Cl)c2N)cn1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.COC(=O)c1ccc2c(=O)[nH]c(CC(C)C)nc2c1.O.O.[K+].[OH-]>>CC(C)Cc1nc2cc(C(=O)O)ccc2c(=O)[nH]1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.Cc1nccn1-c1ccc(NN)nn1>>CC(C)=NNc1ccc(-n2ccnc2C)nn1",
        "output": "285"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.C[Si](C)(C)CCOCN1C(=O)CCCc2cccc(CO)c21.O=S(Cl)Cl.[Cl-].[Li+].c1ccncc1>>C[Si](C)(C)CCOCN1C(=O)CCCc2cccc(CCl)c21",
        "output": "81"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.Cl.O=c1[nH]ccc(O)c1[N+](=O)[O-].[Cl-].[H-].[NH4+].[Na+]>>Cn1ccc(O)c([N+](=O)[O-])c1=O",
        "output": "191"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(C(CC(=O)Nc2ccc(NC(=O)Nc3ccccc3C)cc2)NC(=O)c2ccc(C(=O)OC(C)(C)C)cc2)cc1OC.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(C(CC(=O)Nc2ccc(NC(=O)Nc3ccccc3C)cc2)NC(=O)c2ccc(C(=O)O)cc2)cc1OC",
        "output": "752"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.COc1cc2c(Oc3cc4cccnc4nc3C)ccnc2cc1O.O=C([O-])[O-].OCCCCBr.[K+].[K+]>>COc1cc2c(Oc3cc4cccnc4nc3C)ccnc2cc1OCCCCO",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Cl.Cc1ccccc1.N#Cc1ccc(-c2ncc(N3CCOCC3)cc2N)cc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)cnc1-c1ccc(C#N)cc1",
        "output": "859"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)CCC(=O)CC1.CCO.NO.O>>CC1(C)CCC(=NO)CC1",
        "output": "86"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCOCC1CO1.CN(C)C=O.c1cc(-c2nc(N3CCOCC3)c3sc(CN4CCNCC4)cc3n2)c2cc[nH]c2c1>>CCCCOCC(O)CN1CCN(Cc2cc3nc(-c4cccc5[nH]ccc45)nc(N4CCOCC4)c3s2)CC1",
        "output": "76"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCc1nc2c(N)nc3cc(Oc4ccc([N+](=O)[O-])cc4)ccc3c2n1CC(C)C.CCCc1nc2c(N)nc3cc(Oc4ccccc4[N+](=O)[O-])ccc3c2n1CC(C)C>>CCCc1nc2c(N)nc3cc(Oc4ccccc4N)ccc3c2n1CC(C)C",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)CC[C@@H]1C[C@H](NC(=O)OC(C)(C)C)CC[C@@H]1N.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cl.ClCCl.O.O=C(O)CNC(=O)OCc1ccccc1.On1nnc2ccccc21>>CC(C)(C)OC(=O)CC[C@@H]1C[C@H](NC(=O)OC(C)(C)C)CC[C@@H]1NC(=O)CNC(=O)OCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)CCc1scc(-c2ccc(Cl)cc2OC)c1-c1ccc(O)cc1.O.[Na+].[OH-]>>COc1cc(Cl)ccc1-c1csc(CCC(=O)O)c1-c1ccc(O)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)[C@@H](C)C[C@H](N)C(=O)NC(C)(C)Cc1ccc(F)cc1.O=C(O)C(F)(F)F.O=C(O)c1ccc(-c2cccnc2)cc1>>COC(=O)[C@@H](C)C[C@H](NC(=O)c1ccc(-c2cccnc2)cc1)C(=O)NC(C)(C)Cc1ccc(F)cc1",
        "output": "718"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N1CCc2c(c(N3CCc4ccc(C(=O)O)cc43)nn2C)C1.CO.O=S(Cl)Cl>>COC(=O)c1ccc2c(c1)N(c1nn(C)c3c1CN(C(C)=O)CC3)CC2",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCCC(=O)O.CC(C)(C)OC(=O)N1CCNCC1.CCN=C=NCCCN(C)C.CN1CCOCC1.ClCCl>>C#CCCC(=O)N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COc1cc(Br)c2c(c1OC)C(=O)CC2.Cc1ccccc1.Cl.Cl[Fe](Cl)Cl.N#C[Cu].O.O.O.O.O.O.O>>COc1cc(C#N)c2c(c1OC)C(=O)CC2",
        "output": "531"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CNC(=O)c1ccccc1Nc1nc(Nc2cc([N+](=O)[O-])ccc2OC)nc2c1c(C)nn2C1CCCCO1.[Pd]>>CNC(=O)c1ccccc1Nc1nc(Nc2cc(N)ccc2OC)nc2c1c(C)nn2C1CCCCO1",
        "output": "202"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCCN(C(=O)c2ccc3[nH]c(C(=O)O)cc3c2)CC1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.FC1(F)CCNCC1>>CC(C)(C)OC(=O)N1CCCN(C(=O)c2ccc3[nH]c(C(=O)N4CCC(F)(F)CC4)cc3c2)CC1",
        "output": "605"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(B(O)O)c(N)c1.Fc1ccc(OCc2cn3cc(Br)cnc3n2)cc1>>Cc1ccc(-c2cnc3nc(COc4ccc(F)cc4)cn3c2)c(N)c1",
        "output": "871"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(S(=O)(=O)N(Cc2ccccc2)[C@@H]2CCCC[C@H]2C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(S(=O)(=O)N(Cc2ccccc2)[C@@H]2CCCC[C@H]2C(=O)O)cc1",
        "output": "278"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.Cc1cc(F)ccc1B(O)O.O=C([O-])[O-].O=[N+]([O-])c1cnccc1Cl.[K+].[K+]>>Cc1cc(F)ccc1-c1ccncc1[N+](=O)[O-]",
        "output": "947"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)Cl)cc1.Nc1ccc2ncccc2c1>>CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3ncccc3c2)cc1",
        "output": "68"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1COc1cncc(Br)c1.CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Cc1ccccc1.ClC(Cl)Cl.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(COc2ccc(OCCC3CCNCC3)cc2)cc1>>CC(C)(C)OC(=O)N1CCC[C@H]1COc1cncc(N2CCC(CCOc3ccc(OCc4ccccc4)cc3)CC2)c1",
        "output": "597"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.O=C1CCC(=O)N1Br.O=c1cc2n(n1-c1ccccc1)CCCC2.[Al]>>O=c1c(Br)c2n(n1-c1ccccc1)CCCC2",
        "output": "620"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOCC.COc1cc(Cl)cc(Br)c1Cl.CS(C)=O.[K+]>>COc1cc(Cl)cc(B2OC(C)(C)C(C)(C)O2)c1Cl",
        "output": "942"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.COc1ccc(C(O)(C(C)c2ccc(Br)cc2Cl)C(F)(F)F)cn1.Cl>>CC(c1ccc(Br)cc1Cl)C(O)(c1ccc(=O)[nH]c1)C(F)(F)F",
        "output": "758"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccccc1.Fc1cc(C2CCC3(CC2)OCCO3)cc(F)c1C(F)(F)F.O.O=CO>>O=C1CCC(c2cc(F)c(C(F)(F)F)c(F)c2)CC1",
        "output": "251"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CNC1.O=C(O)C(F)(F)F.O=C1CCC(N2CCCC2=O)CC1.[Na+]>>O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CN(C2CCC(N3CCCC3=O)CC2)C1",
        "output": "187"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN1CCCC1=O.NC1CCc2ccccc21.Nc1nc(Cl)cc(Cl)n1>>Nc1nc(Cl)cc(NC2CCc3ccccc32)n1",
        "output": "165"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[O-].CN(C)C=O.CO.Cc1cccc(CBr)c1F.Cl.Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CO)n1.[Na+]>>Cc1cccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(Cl)cc3)cc2)c1F",
        "output": "464"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN1CCOCC1.COC(=O)CCN.COc1ccc(-n2cc(C(=O)O)c(=O)n(Cc3cccc(Cl)c3Cl)c2=O)cc1.Cl.F[B-](F)(F)F>>COC(=O)CCNC(=O)c1cn(-c2ccc(OC)cc2)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O",
        "output": "737"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(C)=O.O.O=C([O-])[O-].O=C(c1ccccc1)c1ccc(F)cc1.[K+].[K+].c1cc(N2CCNCC2)ccn1>>O=C(c1ccccc1)c1ccc(N2CCN(c3ccncc3)CC2)cc1",
        "output": "26"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.C[C@@H](CCO)NC(=O)OC(C)(C)C.ClCCl>>C[C@@H](CCOS(C)(=O)=O)NC(=O)OC(C)(C)C",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)c1nc(-c2ccccc2Cl)[nH]c1C.[Na+].[OH-]>>Cc1[nH]c(-c2ccccc2Cl)nc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CO.COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Cl)n1.O=C([O-])[O-].Oc1ccccc1.[Cs+].[Cs+].c1ccncc1>>COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccccc2)n1",
        "output": "668"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)c1ccc(Br)nc1.CCN(C(=O)Oc1ccc(F)cc1)[C@@H]1CN(C(=O)C2CCNCC2)C[C@H]1c1ccc(Cl)c(Cl)c1>>CCN(C(=O)Oc1ccc(F)cc1)[C@@H]1CN(C(=O)C2CCN(c3ccc(C(C)=O)cn3)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1",
        "output": "647"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)c1cc2cc(C#N)ccc2[nH]1.Cl.NO.O=C([O-])O.[Na+]>>CCOC(=O)c1cc2cc(C(=N)NO)ccc2[nH]1",
        "output": "854"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.O=C(c1ccccc1)c1cccc(OCCCCCCCCC2OCCO2)c1.[BH4-].[Na+]>>OC(c1ccccc1)c1cccc(OCCCCCCCCC2OCCO2)c1",
        "output": "157"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)NCCc1cccc(N)c1.CCOC(=O)Cl.O.c1ccncc1>>CCOC(=O)Nc1cccc(CCNC(C)=O)c1",
        "output": "102"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.COC(=O)C=Cc1cccc(NC(=O)c2ccc(-c3ccccc3)o2)n1.[Na+].[OH-]>>O=C(O)C=Cc1cccc(NC(=O)c2ccc(-c3ccccc3)o2)n1",
        "output": "58"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(C)=O.O=[N+]([O-])c1cccc2c1CCC2.[Pd]>>Nc1cccc2c1CCC2",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCCCC.CI.Clc1cccc2[nH]ccc12.[H-].[Na+]>>Cn1ccc2c(Cl)cccc21",
        "output": "191"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCOC(=O)CCN.CCOC(C)=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CN1CCOCC1.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2c(c1)C(=O)C(CCC1CCN(C(=O)OCc3ccccc3)CC1)C2>>CCOC(=O)CCNC(=O)c1ccc2c(c1)C(=O)C(CCC1CCN(C(=O)OCc3ccccc3)CC1)C2",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.Nc1cc(C(F)(F)F)c(F)cc1O.O.O=C(Cl)c1ccncc1Cl>>O=C(Nc1cc(C(F)(F)F)c(F)cc1O)c1ccncc1Cl",
        "output": "11"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=Cc1cccc([N+](=O)[O-])c1.[BH4-].[Na+]>>O=[N+]([O-])c1cccc(CO)c1",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(C(=O)O)nc1-c1cccc(Cl)c1.Cc1nc(C(C)(C)N)no1>>Cc1nc(C(C)(C)NC(=O)c2ccc(C)c(-c3cccc(Cl)c3)n2)no1",
        "output": "137"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CN(C)C=O.ClCCCl.Nc1cnccc1CO.O.O=C(O)c1cc(-c2ccncc2)ccc1OCc1ccccc1.On1nnc2ccccc21>>O=C(Nc1cnccc1CO)c1cc(-c2ccncc2)ccc1OCc1ccccc1",
        "output": "759"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1cccc(C)c1OC.O.[K+].[OH-]>>COc1c(C)cccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCNCC4)cc3)nc2c1.ClCCl.O=C(Cl)C1CC1>>COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCN(C(=O)C5CC5)CC4)cc3)nc2c1",
        "output": "125"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)C(=O)N1CC[C@H](c2ccc(O)cc2)[C@H]1C(=O)O.CC(C)(C)OC(=O)[C@@H]1CSSC[C@H](N)C(=O)NCCC2(CCCC2)C(=O)N1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O>>CC(C)(C)OC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H]2[C@@H](c3ccc(O)cc3)CCN2C(=O)C(C)(C)C)C(=O)NCCC2(CCCC2)C(=O)N1",
        "output": "131"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN1CCCC1=O.C[C@@H]1CNCCN1.Cc1c(Cl)nnc(C(=O)c2cccnc2)c1C>>Cc1c(C(=O)c2cccnc2)nnc(N2CCN[C@H](C)C2)c1C",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCOC(=O)c1cnn(-c2cccc(-c3cc(F)ccc3O)n2)c1C(F)(F)F.ClCCl.O=C1CCC(=O)N1Cl>>CCOC(=O)c1cnn(-c2cccc(-c3cc(F)cc(Cl)c3O)n2)c1C(F)(F)F",
        "output": "121"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCOCCOCCOCCOCCO1.CC(C)(C)[O-].CCOCC.ClCc1ccccc1.Fc1ccc2[nH]ccc2c1.O.[K+]>>Fc1ccc2c(ccn2Cc2ccccc2)c1",
        "output": "556"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cn1c(=O)oc2cc(C=CCN3CCN(c4ccc(F)cc4)CC3)ccc21.[Ni]>>Cn1c(=O)oc2cc(CCCN3CCN(c4ccc(F)cc4)CC3)ccc21",
        "output": "362"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Clc1cccc(Cl)c1CBr.O=C([O-])[O-].O=Cc1ccc(O)cc1.[K+].[K+]>>O=Cc1ccc(OCc2c(Cl)cccc2Cl)cc1",
        "output": "127"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.Nc1cccc(Cl)c1.O=C1Cc2cc(S(=O)(=O)Cl)ccc2N1.c1ccncc1>>O=C1Cc2cc(S(=O)(=O)Nc3cccc(Cl)c3)ccc2N1",
        "output": "68"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)c1cc(S(=O)(=O)NC(C)(C)C)cc(S(=O)(=O)NC(C)(C)C)c1.[BH4-].[Li+]>>CC(C)(C)NS(=O)(=O)c1cc(CO)cc(S(=O)(=O)NC(C)(C)C)c1",
        "output": "444"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cl.Cl.NC(=O)c1ncc(Cl)cc1OC[C@H]1CCCN1.O=C(O)[C@H]1CC[C@@H](C(F)(F)F)CC1.O=C(O)c1cc2ccccc2[nH]1>>NC(=O)c1ncc(Cl)cc1OC[C@H]1CCCN1C(=O)[C@@H]1CC[C@H](C(F)(F)F)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CNC.O=Cc1cc([N+](=O)[O-])ccc1Cl>>CN(C)Cc1cc([N+](=O)[O-])ccc1Cl",
        "output": "567"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)CN(CCC(=O)OC(C)(C)C)c1ccc(C(F)(F)F)c(Cl)c1.[BH4-].[Li+]>>CC(C)(C)OC(=O)CCN(CCO)c1ccc(C(F)(F)F)c(Cl)c1",
        "output": "343"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCN1.CCOC(C)=O.COC(=O)c1ccc(C(=O)O)nc1>>COC(=O)c1ccc(C(=O)N2CCOCC2)nc1",
        "output": "605"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC[SiH](CC)CC.O=C(O)C(F)(F)F.O=C1Nc2c(C(F)(F)F)cccc2C1(O)c1cc2c(cc1O)OCO2>>O=C1Nc2c(cccc2C(F)(F)F)C1c1cc2c(cc1O)OCO2",
        "output": "964"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.COc1ccc(CC(=O)O)c(Br)c1.ClCCl>>O=C(O)Cc1ccc(O)cc1Br",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cc(-c2ccc(N)c(C)c2)no1.O=C=Nc1c(F)cccc1F>>CCOC(=O)c1cc(-c2ccc(NC(=O)Nc3c(F)cccc3F)c(C)c2)no1",
        "output": "473"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCC(O)(CCC)CCc1cccc(CC(O)CN)c1>>CCCC(O)(CCC)CCc1cccc(CC(O)CNC(=O)OC(C)(C)C)c1",
        "output": "631"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Fc1cccc(CBr)c1.O=[N+]([O-])c1ccc(O)cc1F>>O=[N+]([O-])c1ccc(OCc2cccc(F)c2)cc1F",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COC(=O)c1ccn2cc(-c3ccccc3)nc2c1.Cl.O.[Na+].[OH-]>>O=C(O)c1ccn2cc(-c3ccccc3)nc2c1",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)c1cc(C(=O)O)[nH]n1.C[C@H](CN)n1ccc(-c2cc(F)c(C#N)c(F)c2)n1>>CC(=O)c1cc(C(=O)NC[C@@H](C)n2ccc(-c3cc(F)c(C#N)c(F)c3)n2)[nH]n1",
        "output": "816"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.NCCO.Nc1nc(Cl)ccc1C(=O)NCc1ccc(Oc2ccccc2)s1.O.O=C(Cc1ccccc1)NCN[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O.[Cl-].[Na+]>>Nc1nc(NCCO)ccc1C(=O)NCc1ccc(Oc2ccccc2)s1",
        "output": "70"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(O)CCl.CN(C)C=O.O.O=C([O-])[O-].Oc1ccccc1Br.[Na+].[Na+]>>CC(C)(O)COc1ccccc1Br",
        "output": "74"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(C(O)c2ccc3c(c2)OCO3)cc1.ClCCl.O=[Mn]=O>>COc1ccc(C(=O)c2ccc3c(c2)OCO3)cc1",
        "output": "59"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNC.CO.O=Cc1cccc(C2c3n[nH]c(=O)c4cccc(c34)NC2c2ccccc2)c1.[BH4-].[Na+]>>CN(C)Cc1cccc(C2c3n[nH]c(=O)c4cccc(c34)NC2c2ccccc2)c1",
        "output": "567"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)[O-].CC(C)C(=O)CC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1.CO.Cl.[BH3-]C#N.[NH4+].[Na+]>>CC(C)C(N)CC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1",
        "output": "63"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCC.CCOC(C)=O.COC(=O)[C@](C)(NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(Cl)cc(OC(F)(F)F)cc1Cl)C1CCCCC1.Cl.O.[Li+].[OH-]>>C[C@](NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(Cl)cc(OC(F)(F)F)cc1Cl)(C(=O)O)C1CCCCC1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(=O)Cl.COC(=O)c1c(C)n([C@H](C)C2CCNCC2)c2ccccc12.c1ccncc1>>COC(=O)c1c(C)n([C@H](C)C2CCN(C(=O)N(C)C)CC2)c2ccccc12",
        "output": "258"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCO)cs1.CC(C)(C)[O-].CN(C)C=O.Clc1ncc(Br)cn1.O.[K+]>>CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCOc2ncc(Br)cn2)cs1",
        "output": "37"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CCBr.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(O)cc1F.[K+].[K+]>>C=CCOc1ccc([N+](=O)[O-])c(F)c1",
        "output": "77"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)Cn1cc(CC#N)c2c(N)cccc21.ClCCl.O=C1CCC(=O)N1Cl>>CC(C)(C)OC(=O)Cn1cc(CC#N)c2c(N)c(Cl)ccc21",
        "output": "121"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)Cn1c(C)c(Cc2ncccc2S(=O)(=O)c2ccc(F)cc2)c2cc(F)ccc21.[Li+].[OH-]>>Cc1c(Cc2ncccc2S(=O)(=O)c2ccc(F)cc2)c2cc(F)ccc2n1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1cccc(CC(=O)O)c1.F[P-](F)(F)(F)(F)F.NC1=c2ccoc2=NCN1c1ccc(N)cc1>>COc1cccc(CC(=O)Nc2ccc(N3CN=c4occc4=C3N)cc2)c1",
        "output": "365"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CO[C@@H]1CCNC1.Cl.F[P-](F)(F)(F)(F)F.O.O=C(O)C1CCN(c2cnccc2-n2cc(Cl)cn2)CC1>>CO[C@@H]1CCN(C(=O)C2CCN(c3cnccc3-n3cc(Cl)cn3)CC2)C1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C1OCC(CO)N1c1ccc(Cl)cc1>>CS(=O)(=O)OCC1COC(=O)N1c1ccc(Cl)cc1",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrC1CC1.N#Cc1ccc(CBr)cc1.O=Cc1ccc(O)cc1.Oc1ccc(C(F)(F)F)nc1>>N#Cc1ccc(COc2ccc(C(F)(F)F)nc2)cc1",
        "output": "623"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CO.NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O>>CC(C)(C)OC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO",
        "output": "631"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.O=C(O)c1ccc2c(c1)-c1nc(-c3ncnn3CC(F)(F)F)cn1CCO2>>O=C(c1ccc2c(c1)-c1nc(-c3ncnn3CC(F)(F)F)cn1CCO2)N1CCOCC1",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCCC(CN)C1.CCN(CC)CC.CN(C)C=O.Cn1nnnc1-c1cccc(NC(=O)Oc2ccccc2)c1>>Cn1nnnc1-c1cccc(NC(=O)NCC2CCCN(C(=O)OC(C)(C)C)C2)c1",
        "output": "488"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.O.O=[N+]([O-])c1ccc(Oc2cccc3ncccc23)c(Cl)c1.[Ca+2].[Cl-].[Cl-]>>Nc1ccc(Oc2cccc3ncccc23)c(Cl)c1",
        "output": "335"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CN1CCN(c2cccc3c2C[C@H](N)CC3)CC1.ClCCl.O=C(Cl)c1ccc(C(F)(F)F)cc1>>CN1CCN(c2cccc3c2C[C@H](NC(=O)c2ccc(C(F)(F)F)cc2)CC3)CC1",
        "output": "271"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=Cc1cccc(Cl)c1Cl.[BH4-].[Na+]>>OCc1cccc(Cl)c1Cl",
        "output": "356"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=O)O.Cc1ccc2c(O)ccnc2c1.O=[N+]([O-])O>>Cc1ccc2c(O)c([N+](=O)[O-])cnc2c1",
        "output": "328"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCC1CCCC1.N#Cc1cccc(Cn2c(-c3ccc(Cl)cc3O)nc3cc(F)c(F)cc32)c1>>N#Cc1cccc(Cn2c(-c3ccc(Cl)cc3OCC3CCCC3)nc3cc(F)c(F)cc32)c1",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc2cc([N+](=O)[O-])ccc2n1.O.O=[Se]=O>>O=Cc1ccc2cc([N+](=O)[O-])ccc2n1",
        "output": "619"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)c1cc(O)cc(-c2c(N)ncnc2N[C@@H](C)c2nn3ccc(C)c3c(=O)n2-c2ccccc2)c1.O.[Li+].[OH-]>>Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3cc(O)cc(C(=O)O)c3)n(-c3ccccc3)c(=O)c12",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CCO.CCOC(C)=O.Cc1nc(Cl)c(C#N)cc1C(=O)OC1CC1.Cl.O=C(NS(=O)(=O)Cc1ccccc1)C1CCNCC1>>Cc1nc(N2CCC(C(=O)NS(=O)(=O)Cc3ccccc3)CC2)c(C#N)cc1C(=O)OC1CC1",
        "output": "220"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCCCCCCCc1ccc(C(=O)c2ccccc2C(=O)O)cc1.ClCCl.O=S(Cl)Cl>>CCCCCCCCCCCCc1ccc(C(=O)c2ccccc2C(=O)Cl)cc1",
        "output": "3"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.CS(C)=O.Cc1cc([N+](=O)[O-])ccc1F>>Cc1cc([N+](=O)[O-])ccc1N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1c(C(=O)O)c(=S)n(C)c2cc(C(F)(F)F)ccc12.NCc1cccc(F)c1>>Cc1c(C(=O)NCc2cccc(F)c2)c(=S)n(C)c2cc(C(F)(F)F)ccc12",
        "output": "790"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@H](CCc1ccccc1)C(=O)O.CCN(C(C)C)C(C)C.ClCCl.Nc1cnc2ccccc2c1.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>>CC(C)(C)OC(=O)N[C@H](CCc1ccccc1)C(=O)Nc1cnc2ccccc2c1",
        "output": "724"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCO.Cn1nc(N2CCC(CN3CCN(S(=O)(=O)c4ccc5c(Cl)cn(S(=O)(=O)c6ccccc6)c5c4)CC3=O)CC2)ccc1=O.[F-]>>Cn1nc(N2CCC(CN3CCN(S(=O)(=O)c4ccc5c(Cl)c[nH]c5c4)CC3=O)CC2)ccc1=O",
        "output": "771"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.COc1ccc(CO)cc1.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.[Na+]>>COc1ccc(COC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cc1",
        "output": "960"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCC(NC(=O)OCc2ccccc2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(NC1CCNCC1)OCc1ccccc1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COC(=O)C(C)c1ccc(-n2cc(Cl)cn2)c(Cl)c1.O.[K+].[OH-]>>CC(C(=O)O)c1ccc(-n2cc(Cl)cn2)c(Cl)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClC(Cl)Cl.FC(F)c1ccc(-c2c[nH]nc2C(F)(F)F)cc1SCC(F)(F)F.O=C(OO)c1cccc(Cl)c1.O=S([O-])[O-].[Na+].[Na+]>>O=S(CC(F)(F)F)c1cc(-c2c[nH]nc2C(F)(F)F)ccc1C(F)F",
        "output": "500"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOCCn1c(N2CCCNCC2)nc2ccccc21.COc1cc(C(=O)N2CCC(CCOS(C)(=O)=O)(c3ccccc3)C2)cc(OC)c1OC.I>>CCOCCn1c(N2CCCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21",
        "output": "496"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.CC(=O)O.COc1ccc(-n2nc(C)cc2C)cc1>>Cc1cc(C)n(-c2ccc(O)cc2)n1",
        "output": "402"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCc1c(OCCCC(=O)O)ccc(C(C)=O)c1O.NCCCc1cccnc1>>CCCc1c(OCCCC(=O)NCCCc2cccnc2)ccc(C(C)=O)c1O",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)OC[C@H](C(F)(F)F)N(C(=O)C1COC1)C2.NO.[Na+].[OH-]>>O=C(NO)c1ccc2c(c1)OC[C@H](C(F)(F)F)N(C(=O)C1COC1)C2",
        "output": "988"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)c1ccc(S(=O)(=O)N2CCC(Sc3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)CC2)n1C.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cn1c(CO)ccc1S(=O)(=O)N1CCC(Sc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)CC1",
        "output": "546"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCCCCC.ClCCl.OCCCc1ccc2ncccc2c1.[Na+].[OH-]>>O=CCCc1ccc2ncccc2c1",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1=COCCC1.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.O=C([O-])O.OCc1ccccc1Br.[Na+].c1cc[nH+]cc1>>Brc1ccccc1COC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)CCCBr.Cc1c(F)c(N)c2c(=O)cc(-c3ccc(NC(=O)C(C)(C)C)c(F)c3)oc2c1F.[H-].[Na+]>>Cc1c(F)c(NCCCC(C)C)c2c(=O)cc(-c3ccc(NC(=O)C(C)(C)C)c(F)c3)oc2c1F",
        "output": "273"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.Cc1cc(C(=O)NC(C)CO)ccc1C(=O)OCc1ccccc1.ClCCl.O=C([O-])O.[Na+]>>Cc1cc(C(=O)NC(C)C=O)ccc1C(=O)OCc1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)CN.O=C(O)c1cccc(-c2ccnc3c(C(=O)c4cccs4)cnn23)c1>>CC(C)CNC(=O)c1cccc(-c2ccnc3c(C(=O)c4cccs4)cnn23)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1nccn1-c1ccc(Nc2nc3c(c(Cc4ccccc4F)n2)CNCC3)cc1.O=CCO>>Cc1nccn1-c1ccc(Nc2nc3c(c(Cc4ccccc4F)n2)CN(CCO)CC3)cc1",
        "output": "484"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.CCn1cc(C=CC(=O)O)nc1-c1ccccc1.Cl.NC1CCNC(=O)C1.O=C([O-])O.O=S(Cl)Cl.[Na+]>>CCn1cc(C=CC(=O)NC2CCNC(=O)C2)nc1-c1ccccc1",
        "output": "549"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN1C(=O)OCCc2ccc(C(=O)OC(C)(C)C)cc21.ClCCl.O=C(O)C(F)(F)F>>CCN1C(=O)OCCc2ccc(C(=O)O)cc21",
        "output": "752"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.ClI.O=Cc1ccccc1O>>O=Cc1cc(I)ccc1O",
        "output": "466"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)c1ccncc1.Cc1ccc(C(C)(C)C)cc1O.ClCCl.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1ccc(C(C)(C)C)cc1OS(=O)(=O)C(F)(F)F",
        "output": "843"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)O.COC(=O)c1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)nc1F.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCN(c2ccc(C(=O)O)c(F)n2)CC1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)OC(=O)/N=N/C(=O)OC(C)C.Cc1ccccc1.O=Cc1ccc(O)cc1.OCCCN(CC(c1ccccc1)c1ccccc1)C(Cl)(c1ccccc1)C(F)(F)F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=Cc1ccc(OCCCN(CC(c2ccccc2)c2ccccc2)C(Cl)(c2ccccc2)C(F)(F)F)cc1",
        "output": "550"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCNCC1.CCO.O=C1Cc2cc(Br)ccc2N1.O=Cc1cc2ccccc2[nH]1>>O=C1Nc2ccc(Br)cc2C1=Cc1cc2ccccc2[nH]1",
        "output": "440"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)CC(O)CNc1nc2ccccc2nc1Cl.CCN(CC)CC.CS(C)=O.N#N>>CC(C)CC(=O)CNc1nc2ccccc2nc1Cl",
        "output": "87"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)c1nccnc1N(C(=O)OC(C)(C)C)c1cccnc1.O.O.[Li+].[OH-]>>CC(C)(C)OC(=O)N(c1cccnc1)c1nccnc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Clc1nc(Cl)c2c(n1)CCC2.O=C([O-])[O-].Oc1ccccc1.[Cs+].[Cs+].[Cu]>>Clc1nc2c(c(Oc3ccccc3)n1)CCC2",
        "output": "668"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOCC.Cc1ccc2cc(C(=O)O)ccc2c1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>Cc1ccc2cc(CO)ccc2c1",
        "output": "72"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCOC(C)=O.C[Si](C)(C)Cl.O=C(OCc1ccccc1)N1CCC(F)(c2ccccc2Cl)CC1.[I-].[Na+]>>FC1(c2ccccc2Cl)CCNCC1",
        "output": "428"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCc1ccc(OCCOC)cc1Oc1ncc(C(F)(F)F)cc1Cl.Cl.[Na+].[OH-]>>COCCOc1ccc(CCC(=O)O)c(Oc2ncc(C(F)(F)F)cc2Cl)c1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "B.C1CCOC1.C1CCOC1.CCOC(=O)c1c(CCC(=O)N(C)C)c[nH]c1C.CO>>CCOC(=O)c1c(CCCN(C)C)c[nH]c1C",
        "output": "112"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCOC(=O)c1cn(-c2ccc3c(c2)n(C)c(=O)n3C)c(=O)n(C2CCc3c2cccc3C(F)(F)F)c1=O.Cl.O.O=C([O-])O.[Na+]>>Cn1c(=O)n(C)c2cc(-n3cc(C(=O)O)c(=O)n(C4CCc5c4cccc5C(F)(F)F)c3=O)ccc21",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.COc1cc(-c2ccc3c(c2)Nc2ccc(CCOc4ccc(N5CCOCC5)cc4)cc2NC3=O)ccc1O.O=C1c2ccccc2C(=O)N1CCCBr.[K+].[OH-]>>COc1cc(-c2ccc3c(c2)Nc2ccc(CCOc4ccc(N5CCOCC5)cc4)cc2NC3=O)ccc1OCCCN1C(=O)c2ccccc2C1=O",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O=C(O)c1cnoc1-c1cccc(F)c1.c1ccc(C2CCNC2)cc1>>O=C(c1cnoc1-c1cccc(F)c1)N1CCC(c2ccccc2)C1",
        "output": "975"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(CCc1ccccc1)C(=O)Cn1ccc(C=O)c1.CO.Cl.[BH4-].[Na+]>>CN(CCc1ccccc1)C(=O)Cn1ccc(CO)c1",
        "output": "476"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCN(CC)CC.CN=C=O.Cl.FC(F)(F)c1cc(CO[C@H]2CCNC[C@H]2c2ccccc2)cc(C(F)(F)F)c1.O>>CNC(=O)N1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1",
        "output": "437"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1cc(C)[nH]n1.Cl.[Na+].[OH-]>>Cc1cc(C(=O)O)n[nH]1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1C(C(=O)Cl)CC2CC1C2(C)C.CO.c1ccncc1>>COC(=O)C1CC2CC(C1C)C2(C)C",
        "output": "126"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.CCOC(=O)CC(O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1.[BH4-].[Cl-].[Li+].[Na+]>>O=C(NCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)CCO",
        "output": "225"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN1CCNCC1.CS(C)=O.N#Cc1ccc(-c2ccc(F)cc2)[nH]c1=O>>CCN1CCN(c2ccc(-c3ccc(C#N)c(=O)[nH]3)cc2)CC1",
        "output": "26"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)c1ccc(NC(=O)c2cc([N+](=O)[O-])ccc2Cl)cc1.CCOC(C)=O.O.O=C([O-])O.[BH4-].[Na+].[Na+]>>CC(O)c1ccc(NC(=O)c2cc([N+](=O)[O-])ccc2Cl)cc1",
        "output": "24"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cnc(-c2cc(N3CCn4cc(C(=O)O)nc4C3)ncc2Cl)c(C)c1.F[P-](F)(F)(F)(F)F>>Cc1cnc(-c2cc(N3CCn4cc(C(=O)N5CCCC5)nc4C3)ncc2Cl)c(C)c1",
        "output": "729"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.C[C@H](N)c1nc2ccc(F)cc2n1Cc1ccccc1.N#Cc1c(N)ncnc1Cl>>C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2n1Cc1ccccc1",
        "output": "110"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)C[C@@H]1CCc2cc(O)ccc21.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.OCCCNc1nc(Cl)ncc1Cl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)C[C@@H]1CCc2cc(OCCCNc3nc(Cl)ncc3Cl)ccc21",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCOC(=O)c1cc2cccnc2n(Cc2ccccc2OC)c1=O.Cl>>COc1ccccc1Cn1c(=O)c(C(=O)O)cc2cccnc21",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)N1CCC(Oc2ccc3c(c2)cc(C(=O)N2CCNCC2)n3CC(F)F)CC1.CN(C)C(=O)Cl.Cl>>CC(C)N1CCC(Oc2ccc3c(c2)cc(C(=O)N2CCN(C(=O)N(C)C)CC2)n3CC(F)F)CC1",
        "output": "258"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc2c(=O)cc(OC)oc2c1.Cc1ccccc1.O.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1cc(=O)c2ccc(O)cc2o1",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COc1cc([N+](=O)[O-])ccc1N1CC[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)C1.[Pd]>>COc1cc(N)ccc1N1CC[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)C1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCNC(=O)c1cccc(C(=O)OC)c1.CO.O.[Li+].[OH-]>>CCNC(=O)c1cccc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#CCOc1ccc(S(=O)(=O)C2(C(=O)OC)CCN(C(=O)OC(C)(C)C)CC2)cc1.Cl.ClCCl>>CC#CCOc1ccc(S(=O)(=O)C2(C(=O)OC)CCNCC2)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.O=C1OCCN1CCO>>CS(=O)(=O)OCCN1CCOC1=O",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.[H-].[N-]=[N+]=NCC(O)Cn1cc([N+](=O)[O-])nc1Cl.[Na+]>>COC(CN=[N+]=[N-])Cn1cc([N+](=O)[O-])nc1Cl",
        "output": "140"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCc1cc(-c2nc(-c3ccc(N)cc3)cs2)ccn1.CN(C)c1ccncc1>>CCCc1cc(-c2nc(-c3ccc(NC(=O)OC(C)(C)C)cc3)cs2)ccn1",
        "output": "735"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC1(C)C(=O)Nc2ccc(F)cc21.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC1(C)CNc2ccc(F)cc21",
        "output": "112"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)NCCc1ccccc1.COC(=O)CCC(=O)O.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-].[Cl-]>>COC(=O)CCC(=O)c1ccc(CCNC(C)=O)cc1",
        "output": "435"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)[C@H]1CC[C@@H](NC(=O)C2(CC(CC(=O)OCc3ccccc3)C(=O)OC(C)(C)C)CCCC2)CC1.[Pd]>>CCOC(=O)[C@H]1CC[C@@H](NC(=O)C2(CC(CC(=O)O)C(=O)OC(C)(C)C)CCCC2)CC1",
        "output": "186"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CSc1ncc2cc(-c3ccccc3Cl)c(=O)n(C)c2n1.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cn1c(=O)c(-c2ccccc2Cl)cc2cnc(S(C)=O)nc21",
        "output": "595"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)Cc1cccc2c(C(C)C)nccc12.CN>>CNC(=O)Cc1cccc2c(C(C)C)nccc12",
        "output": "64"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCOC(=O)C1(c2ccc(OC3CCN(C4CCC4)CC3)cc2)CCOCC1.Cl.O.[Na+].[OH-]>>O=C(O)C1(c2ccc(OC3CCN(C4CCC4)CC3)cc2)CCOCC1",
        "output": "615"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CC(CO)Cc1ccc(Br)cc1.CN(C)C=O.c1c[nH]cn1>>CC(CO[Si](C)(C)C(C)(C)C)Cc1ccc(Br)cc1",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.Cl.ClCCCCBr.O.O=C([O-])[O-].O=c1[nH]cc(-c2cccs2)c(=O)[nH]1.[K+].[K+]>>O=c1[nH]c(=O)n(CCCCCl)cc1-c1cccs1",
        "output": "327"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCc1ccc(OCCOC)cc1O.CN(C)C=O.FC(F)(F)c1cnc(Cl)c(Cl)c1.O.[H-].[Na+]>>CCOC(=O)CCc1ccc(OCCOC)cc1Oc1ncc(C(F)(F)F)cc1Cl",
        "output": "516"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCCC[C@H]1[C@@H](OC(=O)Nc1ccc2[nH]ncc2c1)c1cccc(C(=O)NC2CCCCC2)c1.Cl>>O=C(Nc1ccc2[nH]ncc2c1)O[C@@H](c1cccc(C(=O)NC2CCCCC2)c1)[C@@H]1CCCCN1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)=Cc1cnc(Cl)cc1-c1cc2c(F)cccc2[nH]1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(B3OC(C)(C)C(C)(C)O3)cc12.O.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3cc(-c4cc5c(F)cccc5[nH]4)c(C=C(C)C)cn3)cc12",
        "output": "955"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)c1cnc(CN)cn1.Cl.O=C(O)c1[nH]c(-c2cccs2)cc1-c1ccc(F)cc1>>COC(=O)c1cnc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)cn1",
        "output": "137"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=CBr)c1ccc(F)c(F)c1.CN(C)C=O.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3.O=C(O)[C@@H]1CCCN1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>C/C(=C\\n1c2c(c3cc(C)ccc31)CN(C)CC2)c1ccc(F)c(F)c1",
        "output": "987"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1CN(c2ccc([N+](=O)[O-])c(N)c2)CCO1.CCO.[H][H].[Pd]>>CC1CN(c2ccc(N)c(N)c2)CCO1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.O=C1C=C(c2ccccc2OCc2ccccc2)CC1>>O=C1C=C(c2ccccc2O)CC1",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CCO.CCOc1cc(C=O)ccc1OC.COC(=O)COc1ccc2oc(NC3CCNCC3)nc2c1.COC(=O)c1ccc2oc(N(OC)C3CCN(C(=O)OC(C)(C)C)CC3)nc2c1.O=C(O)C(F)(F)F.[BH3-]C#N.[Na+]>>CCOc1cc(CN2CCC(Nc3nc4cc(OCC(=O)OC)ccc4o3)CC2)ccc1OC",
        "output": "567"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCOCCOCCOCCOCCO1.CC(C)=O.COc1cc(C(C)=O)cc(OC)c1O.N#N.O=C([O-])[O-].OCCCBr.[K+].[K+]>>COc1cc(C(C)=O)cc(OC)c1OCCCO",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C(=O)NC(C(=O)N1CCC2C1CCN2C(=O)OCc1ccccc1)C1CCCCC1)N(C)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CNC(C)C(=O)NC(C(=O)N1CCC2C1CCN2C(=O)OCc1ccccc1)C1CCCCC1",
        "output": "634"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COC1CN(C(=O)c2csc(N3CC(O[Si](c4ccccc4)(c4ccccc4)C(C)(C)C)C3)n2)C1.[F-]>>COC1CN(C(=O)c2csc(N3CC(O)C3)n2)C1",
        "output": "781"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1cc2c(Oc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)ccnc2cc1OC.Cl.O.[Na+].[OH-]>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c2cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc(C(=O)Cl)cc(OC)c1OC.OCCC1(c2ccccc2F)CCNC1>>COc1cc(C(=O)N2CCC(CCO)(c3ccccc3F)C2)cc(OC)c1OC",
        "output": "201"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C(C)(C)N1CCN(Cc2nc3c(N4CCOCC4)nc(Cl)nc3n2C)CC1.c1ccc2[nH]c(C3CC3)nc2c1>>CCOC(=O)C(C)(C)N1CCN(Cc2nc3c(N4CCOCC4)nc(-n4c(C5CC5)nc5ccccc54)nc3n2C)CC1",
        "output": "916"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.O.O=C(CBr)c1ccc(Cl)cc1.O=C([O-])[O-].Oc1ccccc1.[K+].[K+]>>O=C(COc1ccccc1)c1ccc(Cl)cc1",
        "output": "221"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Nc1cc(Br)cc2c1OCO2.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[C-]#N.[C-]#N.[Fe+2].[Pd].[Pd].[Zn+2].[Zn].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>N#Cc1cc(N)c2c(c1)OCO2",
        "output": "65"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)NC(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1nc2ccc(OS(=O)(=O)c3ccc(F)cc3)cc2s1.O.O=C(O)C1CCCC1>>O=C(Nc1nc2ccc(OS(=O)(=O)c3ccc(F)cc3)cc2s1)C1CCCC1",
        "output": "681"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNCCN1.CCSc1ncnc2c(N3CCCCC3)nc(Cl)nc12.CS(C)=O>>CCSc1ncnc2c(N3CCCCC3)nc(N3CCNCC3)nc12",
        "output": "36"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.NCCCN1CCCN(Cc2ccc(Cl)cc2)CC1.O=C=NC1CCCCC1>>O=C(NCCCN1CCCN(Cc2ccc(Cl)cc2)CC1)NC1CCCCC1",
        "output": "244"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClCCl.O=C(NCC(F)(F)F)C1(CCCCN2CCNCC2)c2ccccc2-c2ccccc21.O=C=NCc1ccccc1>>O=C(NCc1ccccc1)N1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1",
        "output": "583"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O.CN(C)c1ccccn1.COc1ccc(COC(=O)Cc2ccccc2O)cc1.ClCCl>>COc1ccc(COC(=O)Cc2ccccc2OC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C)cc1",
        "output": "108"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.Cl.ClCc1ccccn1.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(O)c(Cl)c1.[I-].[K+].[K+].[Na+]>>O=[N+]([O-])c1ccc(OCc2ccccn2)c(Cl)c1",
        "output": "616"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCC2=NCCCN2CC1.CC#N.CCc1nc(-c2ccccc2)cn1-c1ccc(CCNC(=O)Oc2ccccc2)cc1.Cc1ccc(S(N)(=O)=O)nc1>>CCc1nc(-c2ccccc2)cn1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cn2)cc1",
        "output": "690"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)[C@@H]1COCC[C@H]1NC(=O)OCc1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>O=C(N[C@@H]1CCOC[C@H]1CO)OCc1ccccc1",
        "output": "225"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-].OCCCc1ccccn1>>O=CCCc1ccccn1",
        "output": "142"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.Cn1nccc1-c1cc(-c2ccccc2)ccc1O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c(F)c1.[K+].[K+]>>Cn1nccc1-c1cc(-c2ccccc2)ccc1Oc1ccc([N+](=O)[O-])cc1F",
        "output": "564"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCOCC.CCc1ccccc1CCO.II.c1c[nH]cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCc1ccccc1CCI",
        "output": "670"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cn(-c2ccc(N)cc2F)cn1.ClCCl.O=C(Cl)OCc1ccccc1.O=C([O-])O.[Na+].c1ccncc1>>Cc1cn(-c2ccc(NC(=O)OCc3ccccc3)cc2F)cn1",
        "output": "509"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.CCOC(C)=O.ClCCl.ClCc1ccc2ccccc2n1.O=C([O-])[O-].O=C1CCOc2ccc(O)cc21.[I-].[K+].[K+].[Na+]>>O=C1CCOc2ccc(OCc3ccc4ccccc4n3)cc21",
        "output": "616"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCc1nc(I)cn1CCN.O=CC1CC1>>CCc1nc(I)cn1CCNCC1CC1",
        "output": "426"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.CCOC(C)=O.ClCCl.Nc1ccc(C(=O)O)cc1F>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(N)c(F)c2)CC1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)OC(=O)Nc2ccc(OCCCCCl)cc21.Cc1cccc(S)c1>>Cc1cccc(SCCCCOc2ccc3c(c2)C(C)(C)OC(=O)N3)c1",
        "output": "460"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CCN(C(C)C)C(C)C.CN(CC1CCNC1)S(=O)(=O)N1CCN(c2ncnc3[nH]ccc23)CC12CC2.CS(C)=O.F[P-](F)(F)(F)(F)F.O=C(O)CCO>>CN(CC1CCN(C(=O)CCO)C1)S(=O)(=O)N1CCN(c2ncnc3[nH]ccc23)CC12CC2",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(=O)(=O)c1ccc(OCCO)cc1.CSc1ccc(O)cc1.O=C([O-])[O-].OCCCl.[K+].[K+]>>CSc1ccc(OCCO)cc1",
        "output": "74"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CSc1ncc2c(C)nccc2n1.O=[Se]=O>>CSc1ncc2c(C=O)nccc2n1",
        "output": "619"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.Cl.F[P-](F)(F)(F)(F)F.O=C(O)CCNC(=O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1>>CNC(=O)CCNC(=O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H]2[C@H](C1)c1cc(Br)cc3c1N2CC3.COc1ccc(B(O)O)c(Cl)c1>>COc1ccc(-c2cc3c4c(c2)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@H]2N4CC3)c(Cl)c1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Nc1ccc(SCCCC(=O)O)cc1.CNCc1ccccc1OC>>COc1ccccc1CN(C)C(=O)CCCSc1ccc(NC(C)=O)cc1",
        "output": "633"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCCC(N(CCCN=[N+]=[N-])c2cccc(Cl)c2)C1.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCCC(N(CCCN)c2cccc(Cl)c2)C1",
        "output": "89"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(CCCOC(=O)c3ccccc3)c(O)cc12.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(CCCOC(=O)c3ccccc3)c(OS(=O)(=O)C(F)(F)F)cc12",
        "output": "843"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)Oc1ccc2cc(Br)ccc2c1.CN(C)C=O.[Li]CCCC>>CC(C)(C)Oc1ccc2cc(C=O)ccc2c1",
        "output": "638"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccc(S(=O)(=O)OCCOCCN=[N+]=[N-])cc1.Nc1ccc(CO)cc1O.[H-].[Na+]>>[N-]=[N+]=NCCOCCOc1cc(CO)ccc1N",
        "output": "438"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(C)(C)O.CC=C(C)C.CCOC(C)=O.COc1cc(F)ccc1Oc1cc(Cl)c(Cl)cc1C=O.Cl.O.O=P([O-])(O)O.O=S([O-])[O-].[Na+].[Na+].[Na+].[Na+].[O-][Cl+][O-]>>COc1cc(F)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)O",
        "output": "384"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)CC1CCC(c2cccnc2)(N(C)C)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CN(C)C1(c2cccnc2)CCC(CCO)CC1",
        "output": "225"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)S(=O)(=O)N[C@@H]1CN(c2ccccc2)C[C@H]1c1ccc(Br)cc1.CS(=O)(=O)Nc1cccc(B(O)O)c1>>CC(C)S(=O)(=O)N[C@@H]1CN(c2ccccc2)C[C@H]1c1ccc(-c2cccc(NS(C)(=O)=O)c2)cc1",
        "output": "837"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCS(=O)(=O)Nc1ccccc1SC1CCCCC1.O=C([O-])O.O=[N+]([O-])O.[Na+]>>CCS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1SC1CCCCC1",
        "output": "21"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)NCC=O.CC(C)(C)OC(=O)Nc1nc(/C(=N/OC(C)(C)C(=O)OC(C)(C)C)C(=O)N[C@@H]2C(=O)N[C@@H]2CNCCN)cs1.ClCCCl.[Na+]>>CC(C)(C)OC(=O)NCCNCCNC[C@H]1NC(=O)[C@H]1NC(=O)/C(=N\\OC(C)(C)C(=O)OC(C)(C)C)c1csc(NC(=O)OC(C)(C)C)n1",
        "output": "426"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)NS(=O)(=O)c1ccc(-c2ncc(CO)c(Nc3cc(C4CC4)[nH]n3)n2)s1.CCOC(C)=O.ClB(Cl)Cl.ClCCl.O>>NS(=O)(=O)c1ccc(-c2ncc(CO)c(Nc3cc(C4CC4)[nH]n3)n2)s1",
        "output": "680"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN.CCOC(C)=O.O=C(O)C1CC(O)(c2ccc(CN3CCCC3)c(Cl)c2)C1.[Na+].[OH-]>>CCNC(=O)C1CC(O)(c2ccc(CN3CCCC3)c(Cl)c2)C1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(Cc2cc(Cl)c3c(c2)CN(Cc2ccc(OC(F)(F)F)cc2)C3=O)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C1c2c(Cl)cc(CC3CCNCC3)cc2CN1Cc1ccc(OC(F)(F)F)cc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.Nc1ccccc1Nc1ccccc1.O.O=C(Cl)c1ccccc1Br>>O=C(Nc1ccccc1Nc1ccccc1)c1ccccc1Br",
        "output": "11"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.COc1ccc(CCl)cc1.Ic1cn[nH]c1.O=C([O-])[O-].[K+].[K+]>>COc1ccc(Cn2cc(I)cn2)cc1",
        "output": "842"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)Cl.OCC(F)(F)F>>CCOC(=O)OCC(F)(F)F",
        "output": "144"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cl.NOCc1ccccc1.O.O=C([O-])[O-].O=Cc1ccccc1.[K+].[K+]>>C(=NOCc1ccccc1)c1ccccc1",
        "output": "30"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCCN(C)C.C[C@@H](NC(=O)OCc1ccccc1)C(=O)O.Cc1ccc(O[Si](C(C)C)(C(C)C)C(C)C)cc1N.ClCCl.On1nnc2ccccc21>>Cc1ccc(O[Si](C(C)C)(C(C)C)C(C)C)cc1NC(=O)[C@@H](C)NC(=O)OCc1ccccc1",
        "output": "365"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCc2[nH]c3cc(Cl)c(Cl)cc3c2CC1.CCOC(=O)CBr.CN(C)C=O.[H-].[Na+]>>CCOC(=O)Cn1c2c(c3cc(Cl)c(Cl)cc31)CCN(C(=O)OC(C)(C)C)CC2",
        "output": "310"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.Nc1ccc(F)c(-c2n[nH]cc2-c2ccncc2)c1F.O=C(O)Cc1ccc(C(F)(F)F)cc1.On1nnc2ccccc21>>O=C(Cc1ccc(C(F)(F)F)cc1)Nc1ccc(F)c(-c2n[nH]cc2-c2ccncc2)c1F",
        "output": "365"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOc1ccc(N2CCN(Cc3ccccc3)C(C(=O)N(CCOC)c3ccc(-n4ccnc4C)cc3)C2)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCOc1ccc(N2CCN(Cc3ccccc3)C(CN(CCOC)c3ccc(-n4ccnc4C)cc3)C2)cc1",
        "output": "490"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)(C)OC(=O)NCCCc1cc(Br)cc(C2(C#N)CC2)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.ClCCl.[K+]>>CC(C)(C)OC(=O)NCCCc1cc(B2OC(C)(C)C(C)(C)O2)cc(C2(C#N)CC2)c1",
        "output": "942"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)CN(CC(C)C)C(=O)OC(C)(C)C.O.O.[Li+].[OH-]>>CC(C)CN(CC(=O)O)C(=O)OC(C)(C)C",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1ccc(C(=O)N2CCN(CCO)CC2)nc1.NCCO>>O=C(NCCO)c1ccc(C(=O)N2CCN(CCO)CC2)nc1",
        "output": "862"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.O.O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNC[C@H]1Cc1c[nH]c2ccccc12.O=C=NC1CCCCC1>>O=C(NC1CCCCC1)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1",
        "output": "437"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCCCCCO)cc1CC2C(C)(C)C.CO.O.O.[Li]O>>COc1cc2c(cc1OCCCCCCO)CC(C(C)(C)C)n1cc(C(=O)O)c(=O)cc1-2",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C[C@@H]1CCCN(C(=O)c2cc(F)c(F)cc2-c2ncccn2)[C@@H]1CN.FC(F)(F)c1cnc(Cl)nc1>>C[C@@H]1CCCN(C(=O)c2cc(F)c(F)cc2-c2ncccn2)[C@@H]1CNc1ncc(C(F)(F)F)cn1",
        "output": "544"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1ccccn1.C#CCCc1nc2cccc(Cl)c2o1>>Clc1cccc2nc(CCC#Cc3ccccn3)oc12",
        "output": "777"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.O.O=[N+]([O-])c1ccc2c(c1)CNCC2>>CC(=O)N1CCc2ccc([N+](=O)[O-])cc2C1",
        "output": "240"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N(CCO)C(=O)c1nc(CC2(c3ccc(C(F)(F)F)cc3)CCCC2)nc(O)c1OCc1ccccc1.CC(C)N(CCO[Si](C)(C)C(C)(C)C)C(=O)c1nc(CC2(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CCCC2)nc(O)c1OCc1ccccc1>>CC(C)N(CCO)C(=O)c1nc(CC2(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CCCC2)nc(O)c1OCc1ccccc1",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1cccc(C=O)n1.O=S(=O)(O)O.[BH4-].[Na+]>>Cc1cccc(CO)n1",
        "output": "745"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1ccc(C(=O)N2CCN(c3ncccc3NC(C)C)CC2)nc1.NC(CO)CO>>CC(C)Nc1cccnc1N1CCN(C(=O)c2ccc(C(=O)NC(CO)CO)cn2)CC1",
        "output": "862"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc2nc(Cl)c(C(F)(F)F)nc2c1.O=C(O)c1ccc(B(O)O)c(F)c1>>COc1ccc2nc(-c3ccc(C(=O)O)cc3F)c(C(F)(F)F)nc2c1",
        "output": "875"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCn1c(=O)c2[nH]c(C34CCCC(C=O)(CCC3)C4)nc2n(CCC)c1=O.CCOC(C)=O.CN(C)CCN.ClCCl.[Na+]>>CCCn1c(=O)c2[nH]c(C34CCCC(CNCCN(C)C)(CCC3)C4)nc2n(CCC)c1=O",
        "output": "426"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)C1(C)CCN(C2=NOC3(C2)CN(Cc2cc(C4CC4)c(C4CC4)c(F)c2OCC)C3)CC1.[Na+].[OH-]>>CCOc1c(CN2CC3(CC(N4CCC(C)(C(=O)O)CC4)=NO3)C2)cc(C2CC2)c(C2CC2)c1F",
        "output": "281"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@H]1c1cccc(C(C)C)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)c1cccc([C@@H]2CN(C(=O)OC(C)(C)C)C[C@@H]2CO)c1",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Cc1nc(SCCO[Si](C)(C)C(C)(C)C)ccc1[N+](=O)[O-].[Cl-].[NH4+].[Zn]>>Cc1nc(SCCO[Si](C)(C)C(C)(C)C)ccc1N",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1noc(CO)c1-c1ccccc1C(=O)c1ccc(Cl)cc1.ClCCl.O>>Cc1noc(COS(C)(=O)=O)c1-c1ccccc1C(=O)c1ccc(Cl)cc1",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=Cc1ccc(S(=O)(=O)Cl)cc1.Nc1cc(Cl)ccc1F.c1ccncc1>>C=Cc1ccc(S(=O)(=O)Nc2cc(Cl)ccc2F)cc1",
        "output": "68"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccccc1.Nc1ccc(Br)nc1C(=O)O.Nc1ccccc1F.O=S(Cl)Cl>>Nc1ccc(Br)nc1C(=O)Nc1ccccc1F",
        "output": "548"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=O.CC(=O)N[C@@H](Cc1ccc(F)c(Br)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COC(OC)OC.ClCCl.[Na+]>>CC(=O)N[C@@H](Cc1ccc(F)c(Br)c1)[C@H](O)CN(C)[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21",
        "output": "217"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CNOC.COc1ncc(F)cc1C(=O)O.Cl.O=C(n1ccnc1)n1ccnc1>>COc1ncc(F)cc1C(=O)N(C)OC",
        "output": "879"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.Cc1nc(N)ccc1[N+](=O)[O-]>>CC(=O)Nc1ccc([N+](=O)[O-])c(C)n1",
        "output": "394"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)c1c(CCc2ccc(C(F)(F)F)cc2)nc2c(c1-c1ccc(C(=O)O)cc1)C(=O)N1CCC[C@@H]21.ClCCl.NCCCn1ccnc1>>CCOC(=O)c1c(CCc2ccc(C(F)(F)F)cc2)nc2c(c1-c1ccc(C(=O)NCCCn3ccnc3)cc1)C(=O)N1CCC[C@@H]21",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[O-].Cc1ccccc1.Cl.N#Cc1cc(F)cc(Br)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(-c2nc3c(o2)CNCC3)cc1.c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>N#Cc1cc(F)cc(N2CCc3nc(-c4ccccc4)oc3C2)c1",
        "output": "294"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.COC(=O)C(Cc1ccc(Br)cc1)NC(=O)OC(C)(C)C.O.[BH4-].[Li]Cl.[Na+]>>CC(C)(C)OC(=O)NC(CO)Cc1ccc(Br)cc1",
        "output": "343"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1noc(-c2ccc(Br)cc2)c1NC(C)CCCO>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4NC(C)CCCO)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cc3c(cc2F)n2c(=O)n(OCc4ccccc4)c(=O)cc2n3C2CC2)CC1.CCO.[Pd]>>CC(C)(C)OC(=O)N1CCN(c2cc3c(cc2F)n2c(=O)n(O)c(=O)cc2n3C2CC2)CC1",
        "output": "630"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)CN.Cl.Cl.O.On1nnc2ccccc21>>COC(=O)CNC(=O)CNC(=O)OC(C)(C)C",
        "output": "129"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Clc1ccccn1.NCCCO.O.O=O>>OCCCNc1ccccn1",
        "output": "70"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COc1ccc2ccc(O)cc2c1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F.[H-].[Na+]>>COc1ccc2ccc(OS(=O)(=O)C(F)(F)F)cc2c1",
        "output": "843"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(Oc1ccc(C(F)(F)F)cc1)C1CN(Cc2ccccc2)CC1c1ccc(Cl)c(Cl)c1.O=C(Cl)OCC(Cl)(Cl)Cl>>CC(Oc1ccc(C(F)(F)F)cc1)C1CNCC1c1ccc(Cl)c(Cl)c1",
        "output": "84"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN.FC(F)(F)c1ccc(C2COCc3c(Cl)nc(Cl)nc32)cc1>>CCNc1nc(Cl)nc2c1COCC2c1ccc(C(F)(F)F)cc1",
        "output": "110"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(S(=O)(=O)n2cc(-c3cccc(N)c3)cc2C(=O)OCc2ccccc2)cc1.ClCCl.O=C=Nc1ccc(C(F)(F)F)cc1>>Cc1ccc(S(=O)(=O)n2cc(-c3cccc(NC(=O)Nc4ccc(C(F)(F)F)cc4)c3)cc2C(=O)OCc2ccccc2)cc1",
        "output": "473"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cccc(I)c1Br.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1cc(C)c(-c2ccccc2)c(C)c1B(O)O.Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>COc1cccc(-c2c(C)cc(C)c(-c3ccccc3)c2C)c1Br",
        "output": "855"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1NCCc2c1cccc2[N+](=O)[O-].O=C(O)c1cc2ncc(Br)cn2n1>>CC1c2cccc([N+](=O)[O-])c2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "952"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)CCCNC(=O)Nc1nc2ccc(Cl)cc2s1.CO.N>>NC(=O)CCCNC(=O)Nc1nc2ccc(Cl)cc2s1",
        "output": "163"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(CCC(CC1CCCCC1)Oc1cccc2sccc12)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CNCCC(CC1CCCCC1)Oc1cccc2sccc12",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1ccc(-c2ncco2)cc1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC1(C)OB(c2ccc(-c3ncco3)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCC1C2CN(Cc3ccccc3)CC12>>CS(=O)(=O)OCC1C2CN(Cc3ccccc3)CC12",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.N.N#Cc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cc1>>NCc1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)cc1",
        "output": "175"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(N)CO.CCO.CCOC(=O)C(C)O>>CC(CO)NC(=O)C(C)O",
        "output": "64"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C[C@H]1CCC[C@@H](C)N1.O=C(CCCCl)c1ccccc1.[I-].[Na+]>>C[C@H]1CCC[C@@H](C)N1CCCC(=O)c1ccccc1",
        "output": "138"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.I.O=[N+]([O-])c1ccc2[nH]nc(I)c2c1>>Nc1ccc2[nH]nc(I)c2c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Cn1cccc([N+](=O)[O-])c1=O.ClCCl.O=C(O)C(F)(F)F>>O=C(O)Cn1cccc([N+](=O)[O-])c1=O",
        "output": "278"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc(C(=O)O)cc1C.Cc1ccccc1.O=S(=O)(O)O.OCCc1ccccc1>>Cc1ccc(C(=O)OCCc2ccccc2)cc1C",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CNC(C)(CN1CCCC1)c1ccc(-c2ccccc2)cc1.F[P-](F)(F)(F)(F)F.O=C(O)Cn1c(=O)oc2ccc(Cl)cc21>>CN(C(=O)Cn1c(=O)oc2ccc(Cl)cc21)C(C)(CN1CCCC1)c1ccc(-c2ccccc2)cc1",
        "output": "633"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.CN(C)C=O.COC(=O)c1cccc([C@H]2C[C@@H](N)C[C@@H](c3ccccc3)O2)c1.F[P-](F)(F)(F)(F)F.O=C(O)C1(c2ccc3c(c2)OC(F)(F)O3)CC1>>COC(=O)c1cccc([C@H]2C[C@@H](NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)C[C@@H](c3ccccc3)O2)c1",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(=O)c1cn[nH]c(=O)c1-c1ccccc1.CN(C)C=O.ClCCl.OB(O)c1ccccc1.[Cu+2].[NH4+].[OH-].c1ccncc1>>CC(=O)c1cnn(-c2ccccc2)c(=O)c1-c1ccccc1",
        "output": "925"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=P(Cl)(Cl)Cl.[O-][n+]1ccc(-c2csc(Cc3ccccc3)n2)cc1>>Clc1cc(-c2csc(Cc3ccccc3)n2)ccn1",
        "output": "2"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCC(NC2CC2)CC1.CCN(C(C)C)C(C)C.ClCCl.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1CCC(N(C(=O)C(F)(F)F)C2CC2)CC1",
        "output": "397"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCN=C=NCCCN(C)C.COc1ccc(CC(N)C(O)c2ccc(F)cc2)cc1.Cl.O.O=C(O)c1ccc(F)c2ccccc12.On1nnc2ccccc21>>COc1ccc(CC(NC(=O)c2ccc(F)c3ccccc23)C(O)c2ccc(F)cc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCCNc1nc(Nc2cccc(F)c2)ncc1C#Cc1cccc(NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)c1.Cl>>CCCNc1nc(Nc2cccc(F)c2)ncc1C#Cc1cccc(NC(=O)[C@H](C)NC)c1",
        "output": "634"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN.CN(C)C=O.CS(=O)(=O)OCCc1cn(CC(=O)Nc2sc3c(c2C(N)=O)CCCC3)nc1C(F)(F)F.O=CO>>CNCCc1cn(CC(=O)Nc2sc3c(c2C(N)=O)CCCC3)nc1C(F)(F)F",
        "output": "559"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)[C@@H]1C[C@H]1CN=[N+]=[N-].CO.O.[OH-]>>[N-]=[N+]=NC[C@@H]1C[C@H]1C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)C1CCN(c2nc3cc(C(=O)O)ccc3nc2-c2ccccc2)CC1.CI.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc2nc(-c3ccccc3)c(N3CCC(C(=O)OC(C)(C)C)CC3)nc2c1",
        "output": "415"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.N#Cc1cc(Cl)nc(N2CCN(C3CCCCC3)CC2)c1.O=C([O-])[O-].OB(O)c1ccc(C(F)(F)F)cc1.[Cs+].[Cs+].[Pd+2]>>N#Cc1cc(-c2ccc(C(F)(F)F)cc2)nc(N2CCN(C3CCCCC3)CC2)c1",
        "output": "865"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1nc2c(N3CCOCC3)ccnn2c1-c1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)nc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(C)OC(=O)N1CCN(c2ccc(-c3c(CO)nc4c(N5CCOCC5)ccnn34)cn2)CC1",
        "output": "286"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)c1[nH]c(C)c(C(=O)OCC)c1C.O.[K+].[OH-]>>CCOC(=O)c1c(C)[nH]c(C(=O)O)c1C",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.COc1ccc(-c2cc3ccc(O)cc3oc2=O)cc1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1ccc(-c2cc3ccc(OS(=O)(=O)C(F)(F)F)cc3oc2=O)cc1",
        "output": "731"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCOc1ccc(S(=O)(=O)Cl)cc1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.COc1ccc2[nH]cc(CCC#N)c2c1.Cc1ccccc1.O.O=S(=O)([O-])O.[K+].[OH-]>>CCCCOc1ccc(S(=O)(=O)n2cc(CCC#N)c3cc(OC)ccc32)cc1",
        "output": "648"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cc1ccc(C(=O)O)cc1C.O=S(=O)(O)O>>COC(=O)c1ccc(C)c(C)c1",
        "output": "33"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CS(=O)(=O)c1ccc2nc(N)sc2c1.ClCCl.F[P-](F)(F)(F)(F)F.O.O=C(O)C(CC1CCCC1)c1ccc(Cl)c(Cl)c1>>CS(=O)(=O)c1ccc2nc(NC(=O)C(CC3CCCC3)c3ccc(Cl)c(Cl)c3)sc2c1",
        "output": "681"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C[Si](C)(C)[N-][Si](C)(C)C.Cc1cc([N+](=O)[O-])ccc1CBr.O=C(Nc1cc[nH]n1)c1c(F)cccc1F.[Li+]>>Cc1cc([N+](=O)[O-])ccc1Cn1ccc(NC(=O)c2c(F)cccc2F)n1",
        "output": "635"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1cc(C2CCCCC2)c(-c2ccc3nc(-c4sc(C)nc4C)ccc3c2)n1CC(=O)OC(C)(C)C.[Na+].[OH-]>>Cc1nc(C)c(-c2ccc3cc(-c4c(C5CCCCC5)cc(C(=O)O)n4CC(=O)OC(C)(C)C)ccc3n2)s1",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C1COCCN1.CCCCCC.O=C(Cl)c1ccccc1I.[Cl-].[Na+].c1ccccc1>>O=C(c1ccccc1I)N1CCOCC1",
        "output": "201"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc2ncnc(Oc3cccc(N)c3)c2cc1OC.O=C(Nc1cc(C2CCC2)nn1-c1ccccc1)Oc1ccccc1>>COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C5CCC5)nn4-c4ccccc4)c3)c2cc1OC",
        "output": "948"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.CCN(CC)CC.COCc1c(C(=O)OC(C)C)ncc2[nH]c3cccc(Oc4ccc(Cl)cc4)c3c12.[Pd]>>COCc1c(C(=O)OC(C)C)ncc2[nH]c3cccc(Oc4ccccc4)c3c12",
        "output": "253"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc2c(OCCBr)cccc2n1.O=[N+]([O-])c1cccc(OC2CCNCC2)c1>>Cc1ccc2c(OCCN3CCC(Oc4cccc([N+](=O)[O-])c4)CC3)cccc2n1",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN.Cc1ccccc1.N#Cc1nc(Cl)c(-c2cccc(F)c2)nc1C#N>>CCNc1nc(C#N)c(C#N)nc1-c1cccc(F)c1",
        "output": "148"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)N1CC(Cc2ccccc2)(c2cccc(OCCNS(=O)(=O)CC3CC3)c2)C1.O.[Cl-].[Na+].[Na+].[OH-]>>O=S(=O)(CC1CC1)NCCOc1cccc(C2(Cc3ccccc3)CNC2)c1",
        "output": "283"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOCC.CCOc1cc(Cl)ccc1CO.O.O=S(Cl)Cl.c1ccncc1>>CCOc1cc(Cl)ccc1CCl",
        "output": "81"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN.CO.COC(=O)[C@@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NCc1ccccc1>>CCNC(=O)[C@@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NCc1ccccc1",
        "output": "392"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CNc1ccc(C(=O)C(C)C)cc1[N+](=O)[O-].CO.O.[BH4-].[Na+]>>CNc1ccc(C(O)C(C)C)cc1[N+](=O)[O-]",
        "output": "24"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCC#Cc1ccc([N+](=O)[O-])cc1-c1cnco1.CO.[Cl-].[Fe].[NH4+]>>CC(C)(C)OC(=O)NCC#Cc1ccc(N)cc1-c1cnco1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)CCc2cc(C=O)ccc2O1.O=C1Cc2cc(Cl)ccc2N1>>CC1(C)CCc2cc(C=C3C(=O)Nc4ccc(Cl)cc43)ccc2O1",
        "output": "439"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cnn(CCc2ccccc2)c1C.Cl.O.O.[Li+].[OH-]>>Cc1c(C(=O)O)cnn1CCc1ccccc1",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COC(=O)c1n[nH]c2ccccc12.COc1ccc(CCl)cc1.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1nn(Cc2ccc(OC)cc2)c2ccccc12",
        "output": "842"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(O)c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1.c1ccc(CC2CCNCC2)cc1>>O=C(c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1)N1CCC(Cc2ccccc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.Cc1noc(NC(=O)Oc2ccccc2)c1C.FC(F)(F)c1cccc(-c2nc(C3CC4(CCNCC4)C3)cs2)c1.O=C(O)C(F)(F)F>>Cc1noc(NC(=O)N2CCC3(CC2)CC(c2csc(-c4cccc(C(F)(F)F)c4)n2)C3)c1C",
        "output": "525"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCC2C1C(CO)CN2C(=O)OCc1ccccc1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.Oc1ccc(F)c(F)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccccc1>>CC(C)(C)OC(=O)N1CCC2C1C(COc1ccc(F)c(F)c1)CN2C(=O)OCc1ccccc1",
        "output": "550"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1cc(C(=O)N2CC(O)C2)cc(-c2ccc(C)cc2)c1.CO.O.[Li+].[OH-]>>Cc1ccc(-c2cc(C(=O)O)cc(C(=O)N3CC(O)C3)c2)cc1",
        "output": "5"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.C[O-].O.O=C(CCCCCBr)N1CCCc2ccccc21.[Na+]>>COCCCCCC(=O)N1CCCc2ccccc21",
        "output": "95"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)[C@@H](C=C(Cl)C(F)(F)C(F)(F)F)[C@@H]1C(=O)O.ClC(Cl)(Cl)Cl.O=S(Cl)Cl>>CC1(C)[C@@H](C=C(Cl)C(F)(F)C(F)(F)F)[C@@H]1C(=O)Cl",
        "output": "53"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.CN(C)C=O.Fc1cc(Cl)cc2[nH]ncc12.II.O.O=S([O-])([O-])=S.[K+].[Na+].[Na+].[OH-]>>Fc1cc(Cl)cc2[nH]nc(I)c12",
        "output": "923"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.CON.Cl.Cl.O=C(O)CCn1nnnc1S>>CONC(=O)CCn1nnnc1S",
        "output": "480"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(n2ncc3c(Oc4ccccc4C#N)ncnc32)CC1.CC(C)OC(=O)Cl.CCN(C(C)C)C(C)C.CCOc1ccc(Oc2ncnc3c2cnn3C2CCNCC2)c(F)c1.ClCCl.N#Cc1ccccc1Oc1ncnc2c1cnn2C1CCNCC1.O.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F>>CC(C)OC(=O)N1CCC(n2ncc3c(Oc4ccccc4C#N)ncnc32)CC1",
        "output": "219"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)CC(N)c1ccccc1Cl.O=C(O)c1ccc2[nH]nc(I)c2c1>>CC(C)CC(NC(=O)c1ccc2[nH]nc(I)c2c1)c1ccccc1Cl",
        "output": "753"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CNc1ccc(C(=O)N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)cc1[N+](=O)[O-].[Pd]>>CNc1ccc(C(=O)N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)cc1N",
        "output": "489"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc2ccccc2nc1Cl.NN.O>>Cc1cc2ccccc2nc1NN",
        "output": "417"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc(-c2cccc(Cl)n2)cc1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>Clc1cccc(-c2ccc(CBr)cc2)n1",
        "output": "29"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN=C=NCCCN(C)C.Cl.ClCCl.O.O=C(O)c1cccc(Cl)c1>>CC(C)(C)OC(=O)N1CCN(C(=O)c2cccc(Cl)c2)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Clc1ncnc2scc(-c3ccccn3)c12.NC1CCC(N)CC1>>NC1CCC(Nc2ncnc3scc(-c4ccccn4)c23)CC1",
        "output": "723"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cl[Sn](Cl)(Cl)Cl.O.O.O=C([O-])[O-].O=c1[nH]c2c3ccccc3c(=Cc3cccc([N+](=O)[O-])c3)c2n2ccnc12.[Na+].[Na+]>>Nc1cccc(C=c2c3ccccc3c3[nH]c(=O)c4nccn4c23)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN1CCNCC1.ClCCl.NC(=O)c1sc(Nc2cc(C=O)ccc2[N+](=O)[O-])nc1-c1ccc(Cl)cc1.[Na+]>>CN1CCN(Cc2ccc([N+](=O)[O-])c(Nc3nc(-c4ccc(Cl)cc4)c(C(N)=O)s3)c2)CC1",
        "output": "567"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Nc1scc(Cl)c1-c1ncn[nH]1.O=C(O)Cn1c(=O)ccn2nccc12>>O=C(Cn1c(=O)ccn2nccc12)Nc1scc(Cl)c1-c1ncn[nH]1",
        "output": "882"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(I)cc1.COc1ccc(B(O)O)cc1>>COc1ccc(-c2ccc([C@H]3CCC[C@H]3NS(=O)(=O)C(C)C)cc2)cc1",
        "output": "855"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(C)c1nc(C(=O)N2CCOC3(CCNCC3)C2)cs1.O=C(O)C(F)(F)F.OCCc1cc(CBr)ccc1C(F)(F)F>>CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccc(C(F)(F)F)c(CCO)c4)CC3)C2)cs1",
        "output": "248"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.Cl.NCCCN1c2ccccc2CCc2ccc(Cl)cc21.O=S(=O)(Cl)c1ccccc1>>O=S(=O)(NCCCN1c2ccccc2CCc2ccc(Cl)cc21)c1ccccc1",
        "output": "43"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1C(=O)N(NC(=O)[C@H](C)N)c2ccccc2-c2ccc(F)cc21.CO.Cl.ClC(Cl)Cl.O=C(O)[C@@H](O)c1cc(F)cc(F)c1>>CC1C(=O)N(NC(=O)[C@H](C)NC(=O)[C@@H](O)c2cc(F)cc(F)c2)c2ccccc2-c2ccc(F)cc21",
        "output": "133"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[O-].CN(C)C=O.ClCc1ccccc1.OC1CCC2(CC1)OCCO2.[K+]>>c1ccc(COC2CCC3(CC2)OCCO3)cc1",
        "output": "208"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CI.CN(C)C=O.COC(=O)CC1CCn2c1c(Sc1ccc(Cl)cc1)c1c(C(C)O)cc(F)cc12.[H-].[Na+]>>COC(=O)CC1CCn2c1c(Sc1ccc(Cl)cc1)c1c(C(C)OC)cc(F)cc12",
        "output": "140"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=[N+]=[N-].CC(=O)O.CCCCCCCCCCNC(=O)C=Cc1cccc(N2CC(C(=O)O)CC2=O)c1.CCOCC.COCCOC>>CCCCCCCCCCNC(=O)C=Cc1cccc(N2CC(C(=O)OC)CC2=O)c1",
        "output": "60"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Fc1ccc(OCCCI)cc1.O=C1C(=O)c2ccccc2C2=C1SCC1(CCNCC1)O2>>O=C1C(=O)c2ccccc2C2=C1SCC1(CCN(CCCOc3ccc(F)cc3)CC1)O2",
        "output": "184"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1COc2cccc(Oc3ccc([N+](=O)[O-])cn3)c2C1.CCO.NN.O.[Pd]>>CC1COc2cccc(Oc3ccc(N)cn3)c2C1",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)C1(c2ccc(Cl)cc2)CC1.c1ccc(C2CCCN2)cc1>>O=C(N1CCCC1c1ccccc1)C1(c2ccc(Cl)cc2)CC1",
        "output": "633"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C(CCCCCCC=CC[C@@H]1Cc2cc(OC)ccc2[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3O)[C@H]12)CCCC(F)(F)C(F)(F)F.CCOC(C)=O.[C].[Pd]>>CCOC(=O)C(CCCCCCCCC[C@@H]1Cc2cc(OC)ccc2[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3O)[C@H]12)CCCC(F)(F)C(F)(F)F",
        "output": "143"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)O)c3c(c21)CC(C)(C)O3.Nc1ccc(C2CC2)cc1.O=S(Cl)Cl>>Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3ccc(C4CC4)cc3)c3c(c21)CC(C)(C)O3",
        "output": "50"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)CC1CCNCC1.Cl.ClCCl.O.O.O=C(O)CC1OC(C(=O)c2cccc(Cl)c2Cl)c2cc(Cl)ccc2-n2cccc21.On1nnc2ccccc21>>CCOC(=O)CC1CCN(C(=O)CC2OC(C(=O)c3cccc(Cl)c3Cl)c3cc(Cl)ccc3-n3cccc32)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(CC(=O)O)on1.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1>>Cc1cc(CC(=O)N[C@@H]2CC[C@@H](CCN3CCC(c4cccc5c4CCO5)CC3)CC2)on1",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.Cl.ClCCCl.ClCCl.O.O=C(O)c1ccc(-c2ccc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)cc2)cc1F.O[C@H]1CCCNC1.On1nnc2ccccc21>>O=C(c1ccc(-c2ccc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)cc2)cc1F)N1CCC[C@H](O)C1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.Cc1ccc(S(=O)(=O)Cl)cc1.O=[N+]([O-])c1cccc2[nH]ccc12.[H-].[Na+]>>Cc1ccc(S(=O)(=O)n2ccc3c([N+](=O)[O-])cccc32)cc1",
        "output": "648"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)CCN(c1nc(Cl)ncc1[N+](=O)[O-])C1CCCC1(C)C.CCOC(C)=O.[H][H].[Pd]>>CCOC(=O)CCN(c1nc(Cl)ncc1N)C1CCCC1(C)C",
        "output": "660"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)C(C)(C)CC(c1cc(Br)ccc1C)N2.Cl.O.[Na+].[OH-]>>Cc1ccc(Br)cc1C1CC(C)(C)c2cc(C(=O)O)ccc2N1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#Cc1cc(C(=O)Nc2ccc(C#N)c(C(F)(F)F)c2)ccc1C.CO>>C#Cc1cc(C(=O)Nc2ccc(CN)c(C(F)(F)F)c2)ccc1C",
        "output": "175"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)COc1cccc2c1CCCC(N(Cc1ccccc1)C[C@H](O)COc1ccccc1)C2.CO.[H][H].[Pd]>>CCOC(=O)COc1cccc2c1CCCC(NC[C@H](O)COc1ccccc1)C2",
        "output": "84"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.Nc1cccc(OC2CCN(CC3CC3)CC2)n1.O=C(Cl)c1ccc(F)cc1Cl.c1ccncc1>>O=C(Nc1cccc(OC2CCN(CC3CC3)CC2)n1)c1ccc(F)cc1Cl",
        "output": "463"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCI.CCOC(C)=O.CN(C)C=O.Cc1ncc(-c2ccc(-c3nnc4n3CCCC4(Oc3ccc(F)c(F)c3)C(C)(C)O)cc2O)o1.O=C([O-])[O-].[K+].[K+]>>CCOc1cc(-c2nnc3n2CCCC3(Oc2ccc(F)c(F)c2)C(C)(C)O)ccc1-c1cnc(C)o1",
        "output": "198"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCNC.CO.Clc1nc(Cl)c2c(n1)C(c1ccccc1)CC2>>CCN(C)c1nc(Cl)nc2c1CCC2c1ccccc1",
        "output": "296"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cc1ccc2oc(-c3cccc([N+](=O)[O-])c3)nc2n1.O.O.[Na+].[SH-]>>Cc1ccc2oc(-c3cccc(N)c3)nc2n1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(c1ccnc2ccccc12)C(N)C#N.CCO.N.[Ni]>>CC(c1ccnc2ccccc12)C(N)CN",
        "output": "246"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.COc1ccccc1Sc1ccc(C=CC(=O)O)c(Cl)c1Cl.ClCCl>>O=C(O)/C=C/c1ccc(Sc2ccccc2O)c(Cl)c1Cl",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)n1nc(-c2ccc(OCc3ccccc3)cc2)c2ncc(F)cc21.CCO.[Pd]>>CC(C)n1nc(-c2ccc(O)cc2)c2ncc(F)cc21",
        "output": "23"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN1CCCC1CNC(=O)c1cccc(C2Nc3ccc(C(=O)OC)cc3CC2(C)C)c1.CO.[Na+].[OH-]>>CCN1CCCC1CNC(=O)c1cccc(C2Nc3ccc(C(=O)O)cc3CC2(C)C)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.Cl.N[C@H]1CC[C@H](CCN2CCC(C(=O)c3ccc(Cl)cc3)CC2)CC1.O=C(O)c1ccc(N2CCOCC2)cc1>>O=C(N[C@@H]1CC[C@@H](CCN2CCC(C(=O)c3ccc(Cl)cc3)CC2)CC1)c1ccc(N2CCOCC2)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-].OC1CCC2C(CC3CC3)C12>>O=C1CCC2C(CC3CC3)C12",
        "output": "87"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4ccc(CO)cc4)cc23)CC1.O=[Mn]=O>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4ccc(C=O)cc4)cc23)CC1",
        "output": "179"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.ClCCl.O=C(Cl)c1ccc(F)cc1.O=S(=O)(N[C@H]1C[C@H]2CNCCN2C1)c1cccc(C(F)(F)F)c1>>O=C(c1ccc(F)cc1)N1CCN2C[C@@H](NS(=O)(=O)c3cccc(C(F)(F)F)c3)C[C@H]2C1",
        "output": "201"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrBr.CC(=O)O.CCOCC.COc1ccccn1.[Na+].[OH-]>>COc1ccc(Br)cn1",
        "output": "292"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2C(C)(C)COC.CN(C)C=O.CN(C)CCCCl.Cl.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCCN(C)C)cc1CC2C(C)(C)COC",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.Cl.ClCCl.N#C[C@@H]1C[C@@H]1COc1nc(Cl)cc(C(=O)NC23CC(C2)C3)n1.Nc1ncccc1OCC1CCNCC1>>N#C[C@@H]1C[C@@H]1COc1nc(C(=O)NC23CC(C2)C3)cc(N2CCC(COc3cccnc3N)CC2)n1",
        "output": "162"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#C[Si](C)(C)C.C1CCOC1.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=c1[nH]nc(-c2ccc(F)c(F)c2Nc2ccc(I)cc2F)o1.[Cu]I>>C[Si](C)(C)C#Cc1ccc(Nc2c(-c3n[nH]c(=O)o3)ccc(F)c2F)c(F)c1",
        "output": "826"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)C1=C(C=Cc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])CS[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N12.Cl.ClCCl.Cl[Ti](Cl)(Cl)Cl.O>>O=C(Cc1ccccc1)N[C@@H]1C(=O)N2C(C(=O)O)=C(C=Cc3ccc([N+](=O)[O-])cc3[N+](=O)[O-])CS[C@H]12",
        "output": "158"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCC1CO1.O.O=C(Cc1ccccc1)c1ccc(O)cc1.[Na+].[OH-]>>O=C(Cc1ccccc1)c1ccc(OCC2CO2)cc1",
        "output": "15"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=[N+]([O-])c1ccc2c(n1)CCO2.[C].[Pd]>>Nc1ccc2c(n1)CCO2",
        "output": "457"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)NCCCCCCCCNC[C@H](O[Si](C)(C)C(C)(C)C)c5ccc(O)c6[nH]c(=O)ccc56)c4)cc23)c1.COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(CN(C)C(=O)c5cccc(CC(C)=O)c5)c4)cc23)c1.NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12>>COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(CN(C)C(=O)c5cccc(CC(C)NC[C@H](O)c6ccc(O)c7[nH]c(=O)ccc67)c5)c4)cc23)c1",
        "output": "236"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COc1cc(CN(C)C)ccc1[N+](=O)[O-].[Pd]>>COc1cc(CN(C)C)ccc1N",
        "output": "507"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC(OC(=O)N2CCC(Oc3cc(N4CCc5cc(S(C)(=O)=O)ccc54)ncn3)CC2)C1.ClCCl.O=C(O)C(F)(F)F>>CS(=O)(=O)c1ccc2c(c1)CCN2c1cc(OC2CCN(C(=O)OC3CNC3)CC2)ncn1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1nc(CCc2c(-c3ccccn3)noc2C)sc1C(=O)O.F[B-](F)(F)F.NC1CCOCC1>>Cc1nc(CCc2c(-c3ccccn3)noc2C)sc1C(=O)NC1CCOCC1",
        "output": "534"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "B.C1CCOC1.C1CCOC1.O.O=C(O)c1cc(Br)ccc1I>>OCc1cc(Br)ccc1I",
        "output": "72"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cn1c(-c2cnccc2C=O)nc2ccc(Cl)cc21.[BH4-].[Na+]>>Cn1c(-c2cnccc2CO)nc2ccc(Cl)cc21",
        "output": "356"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.COC(=O)c1cc(F)cc(=O)[nH]1.O=C1CCC(=O)N1Br.O=S([O-])O.[Na+]>>COC(=O)c1cc(F)c(Br)c(=O)[nH]1",
        "output": "518"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Cc1ccc(C)n1-c1ccn(-c2ccccc2F)n1.II.O=S([O-])[O-].[Li]CCCC.[Na+].[Na+]>>Cc1ccc(C)n1-c1cc(I)n(-c2ccccc2F)n1",
        "output": "923"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C1CCOC1.CC1(C)CCC(Cc2cc(O)c(-c3ccccc3)c(=O)[nH]2)CC1.CN(C)C=O.CN(C)C=O.O.O=C([O-])[O-].O=P(OCCl)(OCc1ccccc1)OCc1ccccc1.[Cs+].[Cs+]>>CC1(C)CCC(Cc2cc(OCOP(=O)(OCc3ccccc3)OCc3ccccc3)c(-c3ccccc3)c(=O)[nH]2)CC1",
        "output": "375"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CC1CCN(c2ccc([N+](=O)[O-])cc2)CC1.[H][H].[Pd]>>CCOC(=O)CC1CCN(c2ccc(N)cc2)CC1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCOCC.COc1ccc2c(c1)OCCC2=O.O=C1CCC(=O)N1Br>>COc1cc2c(cc1Br)C(=O)CCO2",
        "output": "4"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)c1c(C(=O)O)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CCC1CC(CC(=O)OC(C)(C)C)OC(C)(C)O1.Cc1ccccc1.Cc1ccccc1C.ClCCl.ClP(Cl)(Cl)(Cl)Cl.Nc1ccccc1.O=C(Cl)C(=O)Cl.O=S(=O)(Cl)Cl.c1ccccc1>>CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CCC1CC(CC(=O)OC(C)(C)C)OC(C)(C)O1",
        "output": "739"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCNCCCC(=O)O.O.O=C([O-])[O-].[K+].[K+]>>CCN(CCCC(=O)O)C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)OC(=O)N[C@@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1CO.ClCCl.O=S([O-])([O-])=S.[Na+].[Na+]>>CC(C)(C)OC(=O)N[C@@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1C=O",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)C(=O)Cl.CCN(CC)CC.ClCCl.NCCCCN1CCN(c2csc3cc(F)ccc23)CC1>>CC(C)C(=O)NCCCCN1CCN(c2csc3cc(F)ccc23)CC1",
        "output": "45"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCO.O.[Na+].[OH-].c1cncc(C2CCNC2)c1>>CC(C)(C)OC(=O)N1CCC(c2cccnc2)C1",
        "output": "694"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cl.N#Cc1cc(S(=O)(=O)Nc2ncns2)ccc1F.O=C([O-])[O-].Oc1ccccc1I.[K+].[K+]>>N#Cc1cc(S(=O)(=O)Nc2ncns2)ccc1Oc1ccccc1I",
        "output": "564"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCI.CCOCC.CN(C)C=O.O=C([O-])[O-].Oc1cc(Br)ccc1F.[K+].[K+]>>CCOc1cc(Br)ccc1F",
        "output": "198"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN.CN(C)C=O.ClCCCl.O=C1Cc2c(cccc2-c2cccc(C(=O)O)c2)N1.On1nnc2ccccc21>>CNC(=O)c1cccc(-c2cccc3c2CC(=O)N3)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCS(=O)(=O)N1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>CCCS(=O)(=O)N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(C)=O.O=C(O)CCCc1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCCc1ccccc1",
        "output": "231"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.CCOC(C)=O.Cl.NCc1cccc(Br)c1>>CC(=O)NCc1cccc(Br)c1",
        "output": "206"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=C(Cl)CC1(C(=O)O)CCCC1.CN(C)C(=O)[C@@H](N)Cc1ccc(-c2ccccc2)cc1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)C(F)(F)F>>C=C(Cl)CC1(C(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N(C)C)CCCC1",
        "output": "133"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(Br)C(=O)Br.CCN(CC)CC.Cc1cc(Br)cc(C)c1N.O=C([O-])O.[Na+]>>Cc1cc(Br)cc(C)c1NC(=O)C(C)Br",
        "output": "442"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.N#Cc1ccc(-c2cc(NCc3ccccc3Cl)nc(N)n2)cc1F.NN.O>>Nc1nc(NCc2ccccc2Cl)cc(-c2ccc3c(N)n[nH]c3c2)n1",
        "output": "945"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)OC(=O)/N=N/C(=O)OC(C)C.CCCCCC.COC(=O)Cc1cccc(O)c1.Cc1ccccc1.OCCCBr.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)Cc1cccc(OCCCBr)c1",
        "output": "478"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCOc1ccc(S(=O)(=O)Cl)cc1-c1nc2c(CCC)nn(C)c2c(=S)[nH]1.CN1CCNCC1>>CCCOc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1-c1nc2c(CCC)nn(C)c2c(=S)[nH]1",
        "output": "99"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)n1nc2c(c1NC(=O)c1ccccc1CN1C(=O)c3ccccc3C1=O)CNC2(C)C.Cl.ClCCl.O=S(=O)(Cl)c1cc(F)cc(F)c1>>CCOC(=O)n1nc2c(c1NC(=O)c1ccccc1CN1C(=O)c3ccccc3C1=O)CN(S(=O)(=O)c1cc(F)cc(F)c1)C2(C)C",
        "output": "99"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)c1ccncc1.ClCCl.N[C@H](CCO)c1ccc(Cl)c(Cl)c1.O>>CC(C)(C)[Si](C)(C)OCC[C@@H](N)c1ccc(Cl)c(Cl)c1",
        "output": "193"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(C)=O.COc1ncc(Cl)cc1CN1CCC(/C=C/c2ccccc2F)CC1.Cl.O=C([O-])[O-].[Na+].[Na+]>>O=c1[nH]cc(Cl)cc1CN1CCC(/C=C/c2ccccc2F)CC1",
        "output": "758"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.Nc1cc(N2CCC[C@@H]2CO)c(Cl)cc1[N+](=O)[O-].[Pt]>>Nc1cc(Cl)c(N2CCC[C@@H]2CO)cc1N",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(C)=O.CCn1c(-c2ccc(N3CCCS3(=O)=O)cc2)c(C#N)c2ccc(O)cc21.CN(C)C=O.Cl.ClCCN1CCOCC1.O.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CCn1c(-c2ccc(N3CCCS3(=O)=O)cc2)c(C#N)c2ccc(OCCN3CCOCC3)cc21",
        "output": "74"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCN(C)C1CCN(C(=O)OC(C)(C)C)CC1.CCOC(C)=O.Cl>>CCCN(C)C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.O=Cc1ccc(O)c2ccccc12.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>O=Cc1ccc(OS(=O)(=O)C(F)(F)F)c2ccccc12",
        "output": "731"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC1(CO)CC=CC1.CCCCCCCCCCCCBr.[H-].[Na+]>>CCCCCCCCCCCCOCC1(C)CC=CC1",
        "output": "95"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CN(C)C=O.CNC(=O)c1ccc(C(=O)OC)c(-n2c(C)cc(O)c(Br)c2=O)c1.Fc1ccc(CBr)c(F)c1.O.O=C([O-])[O-].[Cl-].[K+].[K+].[Na+]>>CNC(=O)c1ccc(C(=O)OC)c(-n2c(C)cc(OCc3ccc(F)cc3F)c(Br)c2=O)c1",
        "output": "127"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CCN(CC)CC.CCc1ccc(C(=O)N2CCC3(CC2)Oc2cc(C(=O)O)ccc2-n2cccc23)cc1OC.O.[BH4-].[Na+]>>CCc1ccc(C(=O)N2CCC3(CC2)Oc2cc(CO)ccc2-n2cccc23)cc1OC",
        "output": "72"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)C1(Sc2ccccc2Br)CCCCC1.[Na+].[OH-]>>O=C(O)C1(Sc2ccccc2Br)CCCCC1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(N)CO.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc2c(c1)c(-c1cc3c(C(=O)O)ccnc3[nH]1)cn2C.F[P-](F)(F)(F)(F)F>>COc1ccc2c(c1)c(-c1cc3c(C(=O)NC(C)(C)CO)ccnc3[nH]1)cn2C",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COC(=O)c1nccnc1N.ClCCl.O=C(O)Cc1ncc(Cl)cc1Cl.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>>COC(=O)c1nccnc1NC(=O)Cc1ncc(Cl)cc1Cl",
        "output": "692"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2ccc(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)n2)C1.ClCCl.O=C(O)C(F)(F)F>>NC(=O)c1ccc(C2CCNC2)nc1-c1ccc(Oc2ccccc2)cc1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C(C)(C)c1ccc(Br)cc1.CCOC(=O)C(C)(C)c1ccsc1>>CC(C)(C(=O)O)c1ccsc1",
        "output": "615"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)CBr.O=[N+]([O-])c1ccc(N2CC(O)C2)nc1.[H-].[Na+]>>CC(C)(C)OC(=O)COC1CN(c2ccc([N+](=O)[O-])cn2)C1",
        "output": "669"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)[C@H](CSc1ccc(C(=O)O)cc1N)NC(=O)OC(C)(C)C.COC(C)(C)C.[Na+].[OH-]>>CC(C)(C)OC(=O)N[C@@H](CSc1ccc(C(=O)O)cc1N)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)O.CC1(C)O/C(=C2/C(=O)Nc3cc(F)ccc32)C=C1c1ccc(C=O)cc1.CN(C)C=O.CO.O.O=C([O-])O.OCCOCCN1CCNCC1.[BH3-]C#N.[Na+].[Na+]>>CC1(C)O/C(=C2/C(=O)Nc3cc(F)ccc32)C=C1c1ccc(CN2CCN(CCOCCO)CC2)cc1",
        "output": "567"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)N(C)C.COC(=O)c1ccc(Cl)cc1NC(=O)c1sccc1Cl.[Na+].[OH-]>>O=C(O)c1ccc(Cl)cc1NC(=O)c1sccc1Cl",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.Cc1nc(CCO)ccc1[N+](=O)[O-].ClCCl.O.c1c[nH]cn1>>Cc1nc(CCO[Si](C)(C)C(C)(C)C)ccc1[N+](=O)[O-]",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(=O)NCc1nc(-c2ccc(OC)cc2)c(-c2ccc(OCCN)cc2)o1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CCC(=O)NCc1nc(-c2ccc(OC)cc2)c(-c2ccc(OCCNS(C)(=O)=O)cc2)o1",
        "output": "493"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCn1nc(C2CCN(C(=O)OC(C)(C)C)CC2)nc1-c1cnc(N)c(-c2nnc(C(C)(C)C)o2)n1.ClCCl.O=C(O)C(F)(F)F>>CCn1nc(C2CCNCC2)nc1-c1cnc(N)c(-c2nnc(C(C)(C)C)o2)n1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.Cl.ClC(Cl)Cl.ClCCl.N#CCN.O=C(Cl)c1cccc2ccccc12>>N#CCNC(=O)c1cccc2ccccc12",
        "output": "271"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccc(Br)cc1.CN(C)C=O.OC1CCNCC1>>OC1CCN(Cc2ccc(Br)cc2)CC1",
        "output": "248"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.O=C(O)c1ccc(I)cc1.O=S(Cl)Cl>>CCOC(=O)c1ccc(I)cc1",
        "output": "33"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCOC[C@H]1c1ncc(-c2ccc(-c3ccc(C(=O)Nc4ccc(CN5CCS(=O)(=O)CC5)cc4)cc3)cc2)[nH]1.Cl.O=C([O-])[O-].[K+].[K+]>>O=C(Nc1ccc(CN2CCS(=O)(=O)CC2)cc1)c1ccc(-c2ccc(-c3cnc([C@@H]4COCCN4)[nH]3)cc2)cc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCOC(=O)CCCOc1ccccc1N1CCNCC1.OCCCBr>>CCOC(=O)CCCOc1ccccc1N1CCN(CCCO)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1ccc(N2CCCCC2C)c([N+](=O)[O-])c1.CCOC(C)=O.CO.[Pd]>>CCOC(=O)c1ccc(N2CCCCC2C)c(N)c1",
        "output": "481"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2ccc(N)cc2)CC1.CO.ClI.O.O=C([O-])[O-].[Ca+2]>>CC(C)(C)OC(=O)N1CCC(c2ccc(N)c(I)c2)CC1",
        "output": "466"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.CN=C=S.NCCCNc1ccccn1>>CNC(=S)NCCCNc1ccccn1",
        "output": "79"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1ccc2c(c1)nc(C(=O)NC1CCN(C3CC3)CC1)n2Cc1cc(-c2ccc(Cl)s2)on1.[Li+].[OH-]>>O=C(O)c1ccc2c(c1)nc(C(=O)NC1CCN(C3CC3)CC1)n2Cc1cc(-c2ccc(Cl)s2)on1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)CCCNCC(=O)CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1.Cl.[Na+].[OH-]>>O=C(O)CCCNCC(=O)CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cc(Br)ccc1CBr.O=C(c1ccccc1)c1cnc2c(C(F)(F)F)cccc2c1-c1cccc(O)c1>>COc1cc(Br)ccc1COc1cccc(-c2c(C(=O)c3ccccc3)cnc3c(C(F)(F)F)cccc23)c1",
        "output": "127"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cc1ncc2c(n1)-c1ccccc1N(C(=O)c1ccc([N+](=O)[O-])cc1)CC2.NN.[Pd]>>Cc1ncc2c(n1)-c1ccccc1N(C(=O)c1ccc(N)cc1)CC2",
        "output": "28"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(=O)(=O)Nc1n[nH]c2ccc(N)cc12.O=S(=O)(Cl)c1cccc(F)c1.c1ccncc1>>CS(=O)(=O)Nc1n[nH]c2ccc(NS(=O)(=O)c3cccc(F)c3)cc12",
        "output": "68"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C1CCOc2c1cc(Cl)c(Oc1ccc(C(=O)O)cc1)c2Br.CCOC(C)=O.Cl.Cl.Nc1cccc(-c2ccc(Cl)cc2)n1.O=S(Cl)Cl>>CCOC(=O)C1CCOc2c1cc(Cl)c(Oc1ccc(C(=O)Nc3cccc(-c4ccc(Cl)cc4)n3)cc1)c2Br",
        "output": "744"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CCOCCl.CO.C[C@@H]1CC[C@@]2(OC1)O[C@H]1C[C@H]3[C@@H]4CC=C5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]3(C)[C@H]1[C@@H]2C.ClCCCl>>CCOCO[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@@H]2CC[C@]2(C)[C@@H]4[C@H](C[C@@H]32)O[C@]2(CC[C@@H](C)CO2)[C@H]4C)C1",
        "output": "598"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CS(C)=O.Cc1ccccc1.FC(F)(F)c1ccc(Cl)nc1Cl.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(c2ccc(C(F)(F)F)c(Cl)n2)CC1",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=COCCON.CCN(C(C)C)C(C)C.CCOCC.Cc1cc(I)ccc1Nc1c(C(=O)O)cc(F)c(F)c1F.ClCCl.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>C=COCCONC(=O)c1cc(F)c(F)c(F)c1Nc1ccc(I)cc1C",
        "output": "741"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)CCCc1ccccc1F.CCO.CCOC(=O)C(=O)OCC.CC[O-].[Na+]>>CCOC(=O)C(=O)CC(=O)CCCc1ccccc1F",
        "output": "526"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=[N+]([O-])c1ccc(F)cc1O[C@@H]1CCCC[C@H]1O.[H][H].[Pd]>>Nc1ccc(F)cc1O[C@@H]1CCCC[C@H]1O",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1cccc(-n2c(=O)c(=O)[nH]c3c4c(ccc32)CCCC4)c1.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl.c1ccncc1>>O=c1[nH]c2c3c(ccc2n(-c2cccc(NS(=O)(=O)c4ccccc4[N+](=O)[O-])c2)c1=O)CCCC3",
        "output": "68"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.COCC(C)O.Cc1ccc(S(=O)(=O)O)cc1.O=C(O)Cc1cccc(Oc2ccc(C(F)(F)F)cc2Cl)c1.c1ccccc1>>COCC(C)OC(=O)Cc1cccc(Oc2ccc(C(F)(F)F)cc2Cl)c1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.Cl.Clc1ncc(Cl)c(Cl)n1.Nc1cccc(NC(=O)Cc2cccc([N+](=O)[O-])c2)c1.O=C([O-])[O-].[K+].[K+]>>O=C(Cc1cccc([N+](=O)[O-])c1)Nc1cccc(Nc2nc(Cl)ncc2Cl)c1",
        "output": "352"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C(Cc1ccc(-c2ccc(C(F)(F)F)cn2)cc1)c1c(SC(C)(C)C)c2cc(O)ccc2n1C.Cl.ClCc1ccc2ccccc2n1>>CCOC(=O)C(Cc1ccc(-c2ccc(C(F)(F)F)cn2)cc1)c1c(SC(C)(C)C)c2cc(OCc3ccc4ccccc4n3)ccc2n1C",
        "output": "616"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccccc1.O=C(O)C(F)(F)F.c1ccc(COc2ccc(-n3cncc3-c3ccncc3)cc2)cc1>>Oc1ccc(-n2cncc2-c2ccncc2)cc1",
        "output": "698"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN=C=NCCCN(C)C.CN.CN(C)C=O.Cl.O.O=C(O)c1ccnc(F)c1F.On1nnc2ccccc21>>CNC(=O)c1ccnc(F)c1F",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1cccc(Br)c1.C1CCOC1.CC(C)(C)OC(=O)N1CCNCC1.CCN(CC)CC>>CC(C)(C)OC(=O)N1CCN(Cc2cccc(Br)c2)CC1",
        "output": "248"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(CO[Si](C)(C)C(C)(C)C)CC(=O)NCCS1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1ccccc1>>CC1(CO[Si](C)(C)C(C)(C)C)CC(=S)NCCS1",
        "output": "695"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.CCOC(C)=O.Cc1ccc(-c2nc(C)c(CN=[N+]=[N-])s2)s1.Cl.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1ccc(-c2nc(C)c(CN)s2)s1",
        "output": "89"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1C[C@H](C(=O)O)C1(C)C.CCN(CC)CC.COC(=O)[C@@H](N)C(C)C.Cl.ClCCl.On1nnc2ccccc21>>COC(=O)[C@@H](NC(=O)[C@H]1C[C@@H](NC(=O)OC(C)(C)C)C1(C)C)C(C)C",
        "output": "129"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C[C@H](N)C(N)=O.O=C(O)c1ccc(C2CC2)c(OCc2ccccn2)n1>>CC(C)C[C@H](NC(=O)c1ccc(C2CC2)c(OCc2ccccn2)n1)C(N)=O",
        "output": "738"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.CCOC(C)=O.Cl.FC1(F)CCNC1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(Cl)c(-c2cncnc2)c1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCC(F)(F)C2)c(-c2cncnc2)c1",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.NCc1cccc(-n2nc(C(F)(F)F)cc2-c2ccco2)c1>>CC(C)(C)OC(=O)NCc1cccc(-n2nc(C(F)(F)F)cc2-c2ccco2)c1",
        "output": "686"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(O)(c1ccc(I)cc1)C(F)(F)F.O=C1N(c2ccc(C(O)C(F)(F)F)cc2)CCC12CCN(S(=O)(=O)C1CC1)CC2.O=C1NCCC12CCN(S(=O)(=O)C1CC1)CC2>>CC(O)(c1ccc(N2CCC3(CCN(S(=O)(=O)C4CC4)CC3)C2=O)cc1)C(F)(F)F",
        "output": "921"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC(C(=O)O)C1.CCN(CC)CC.CN(C)C=O.Nc1ncnn2c(C3CCNC3)cc(-c3ccc4cn(Cc5ccccc5)nc4c3)c12>>CC(C)(C)OC(=O)N1CC(C(=O)N2CCC(c3cc(-c4ccc5cn(Cc6ccccc6)nc5c4)c4c(N)ncnn34)C2)C1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)c1sccc1S(=O)(=O)Nc1ccc(N2CCC(=O)CC2)cc1.CS(=O)(=O)Nc1cc([C@@H](O)CN)ccc1O>>COC(=O)c1sccc1S(=O)(=O)Nc1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1",
        "output": "236"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.Nc1cccc(-c2ccc3c(c2)CC(c2cc(Cl)cc(Cl)c2)(C(F)(F)F)O3)c1F.O.O=C(Cl)C1CC1>>O=C(Nc1cccc(-c2ccc3c(c2)CC(c2cc(Cl)cc(Cl)c2)(C(F)(F)F)O3)c1F)C1CC1",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOc1cc(C#N)ccc1C(=O)O.CO.C[Si](C)(C)C=[N+]=[N-].c1ccccc1>>CCOc1cc(C#N)ccc1C(=O)OC",
        "output": "195"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.[N-]=[N+]=NC1CCCc2cccnc21.[Pd]>>NC1CCCc2cccnc21",
        "output": "89"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(Cc1cn(Cc2ccccc2)c2ccccc12)C(=O)OCc1ccccc1.CO.[OH-].[OH-].[Pd+2]>>CNCc1cn(Cc2ccccc2)c2ccccc12",
        "output": "428"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCC(N)c1cccc(Cl)c1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ncc2cc(C(=O)Nc3cc(C(=O)O)ccc3Cl)c(=O)[nH]c2n1.F[P-](F)(F)(F)(F)F>>COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CNC(=O)OC(C)(C)C)c4cccc(Cl)c4)ccc3Cl)c(=O)[nH]c2n1",
        "output": "753"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)N(c1ccccc1)C1(c2nc(C)cs2)CCNCC1.CCN(CC)CC.CCOC(C)=O.O=S(=O)(Cl)c1ccccc1>>CC(=O)N(c1ccccc1)C1(c2nc(C)cs2)CCN(S(=O)(=O)c2ccccc2)CC1",
        "output": "99"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.Nc1ccc(SCC(F)(F)C(F)F)cc1[N+](=O)[O-].[NH4+].[OH-]>>Nc1ccc(SCC(F)(F)C(F)F)cc1N",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Fc1cc(C(F)(F)F)ccc1CCl.N#Cc1c[nH]c2ccc(CC(=O)O)cc2c1=O>>N#Cc1cn(Cc2ccc(C(F)(F)F)cc2F)c2ccc(CC(=O)O)cc2c1=O",
        "output": "556"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.CS(=O)(=O)OCCCc1ccc(Cl)c(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1.NCCCCO>>O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(CCCNCCCCO)ccc1Cl",
        "output": "559"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.O.O=C[O-].O=c1[nH]c2cnc3[nH]ccc3c2n1[C@@H]1CCCN(c2ccc([N+](=O)[O-])cn2)C1.[NH4+].[Pd]>>Nc1ccc(N2CCC[C@@H](n3c(=O)[nH]c4cnc5[nH]ccc5c43)C2)nc1",
        "output": "269"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.Cc1c(F)cccc1C(=O)O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cccc(F)c1C",
        "output": "415"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CC(C)(C)OC(=O)CCc1cc(Cl)cc[n+]1[O-].CN(C)C(=O)Cl.C[Si](C)(C)C#N>>CC(C)(C)OC(=O)CCc1cc(Cl)cc(C#N)n1",
        "output": "720"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=C(O)c1ccccc1-n1cccn1.c1ccc2nc(N3CC4CNCC4C3)cnc2c1>>O=C(c1ccccc1-n1cccn1)N1CC2CN(c3cnc4ccccc4n3)CC2C1",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NC1CNc2ccccc2C1.O.[Br-].[Br-].[Br-].c1cc[nH+]cc1.c1cc[nH+]cc1.c1cc[nH+]cc1>>CC(C)(C)OC(=O)NC1CNc2ccc(Br)cc2C1",
        "output": "784"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=C(Nc1ccccc1)c1cccc([N+](=O)[O-])c1O.[Pd]>>Nc1cccc(C(=O)Nc2ccccc2)c1O",
        "output": "489"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cccc(Nc2ncc(Cl)c(-c3cn(S(=O)(=O)c4ccccc4)c4ccccc34)n2)c1>>CC(C)(C)OC(=O)NCC(=O)Nc1cccc(Nc2ncc(Cl)c(-c3cn(S(=O)(=O)c4ccccc4)c4ccccc34)n2)c1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CS(=O)(=O)Nc1cc([N+](=O)[O-])ccc1F.OC1CCCCC1>>CS(=O)(=O)Nc1cc([N+](=O)[O-])ccc1OC1CCCCC1",
        "output": "485"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc2c(Cl)nc(Nc3cc[nH]n3)cc2c1.OB(O)c1ccc(Cl)cc1>>COc1ccc2c(-c3ccc(Cl)cc3)nc(Nc3cc[nH]n3)cc2c1",
        "output": "865"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cl.O.O=C1NCCN(S(=O)(=O)c2ccc(Cl)c([N+](=O)[O-])c2)c2ccccc21.[Na+].[OH-]>>Nc1cc(S(=O)(=O)N2CCNC(=O)c3ccccc32)ccc1Cl",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)C(C)(C)Sc1ccccc1-c1ccc(C2CC2)nc1.CO.[Na+].[OH-]>>CC(C)(Sc1ccccc1-c1ccc(C2CC2)nc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CN(C(=O)c1ccccc1)C1CCNCC1.Cc1c[nH]c2ncnc(Cl)c12>>Cc1c[nH]c2ncnc(N3CCC(N(C)C(=O)c4ccccc4)CC3)c12",
        "output": "540"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.Cl.NC(Cc1c[nH]c2ccccc12)C(F)(F)F.O=S(=O)(Cl)c1c(Cl)cc(Br)cc1Cl.c1ccncc1>>O=S(=O)(NC(Cc1c[nH]c2ccccc12)C(F)(F)F)c1c(Cl)cc(Br)cc1Cl",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.N.O=C(O)Cc1nnc(C[C@@H]2CCc3cc(C(O)(C(F)(F)F)C(F)(F)F)ccc3N2S(=O)(=O)c2ccc(F)cc2)o1>>NC(=O)Cc1nnc(C[C@@H]2CCc3cc(C(O)(C(F)(F)F)C(F)(F)F)ccc3N2S(=O)(=O)c2ccc(F)cc2)o1",
        "output": "313"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1ccc2c(c1)c(C)c(C)n2Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.Cl.[Na+].[OH-]>>Cc1c(C)n(Cc2ccc(-c3ccccc3C(=O)OC(C)(C)C)cc2)c2ccc(C(=O)O)cc12",
        "output": "5"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)(C)OC(=O)N1CCC[C@H]1c1nnc(-c2ccc(Br)cc2)[nH]1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(C)OC(=O)N1CCC[C@H]1c1nnc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)[nH]1",
        "output": "942"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)CC1=C(n2nc(-c3c(-c4ccccc4)nn4ccccc34)ccc2=O)CCCCC1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)CC1=C(n2nc(-c3c(-c4ccccc4)nn4ccccc34)ccc2=O)CCCCC1",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.ClCCl.OB(O)c1ccccc1.Oc1ccc2c(c1)NCCC2.[Cu+2]>>c1ccc(Oc2ccc3c(c2)NCCC3)cc1",
        "output": "920"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCBr.CCO.Cc1ccc(N)cc1O.O.O=C([O-])[O-].[Na+].[Na+]>>CCNc1ccc(C)c(O)c1",
        "output": "273"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)[C@@H](N)CC(C)C.CSCC[C@H](N)C(=O)O.Cl.O=C(O)c1ccc([N+](=O)[O-])cc1-c1ccccc1>>COC(=O)[C@H](CC(C)C)NC(=O)c1ccc([N+](=O)[O-])cc1-c1ccccc1",
        "output": "652"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN.CO.ClCCl.NC(=O)c1cc(-c2ccc(C=O)s2)cc2c(C3CCN(S(=O)(=O)CCCN4CCOCC4)CC3)c[nH]c12.[BH4-].[Na+]>>CNCc1ccc(-c2cc(C(N)=O)c3[nH]cc(C4CCN(S(=O)(=O)CCCN5CCOCC5)CC4)c3c2)s1",
        "output": "691"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COCCOc1cc(Cl)c(C(=O)O)c(Cl)c1.C[NH3+].Cl.F[P-](F)(F)(F)(F)F.F[P-](F)(F)(F)(F)F.NCc1ccc(Br)cc1>>COCCOc1cc(Cl)c(C(=O)NCc2ccc(Br)cc2)c(Cl)c1",
        "output": "753"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NCC(O)(Cn1cncn1)c1ccc(Cl)cc1Cl.O=[N+]([O-])c1cc(C(F)(F)F)ccc1S(=O)(=O)Cl>>O=[N+]([O-])c1cc(C(F)(F)F)ccc1S(=O)(=O)NCC(O)(Cn1cncn1)c1ccc(Cl)cc1Cl",
        "output": "43"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)CCc1ccc(F)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCc1ccc(F)cc1",
        "output": "225"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cccc([C@H]2CCC[C@H]2N2C(=O)c3ccccc3C2=O)c1.Cc1ccccc1.NN>>COc1cccc([C@H]2CCC[C@H]2N)c1",
        "output": "242"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC1CNCC(C)O1.CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cccc(C=O)c4)cc23)CC1.[Na+]>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cccc(CN5CC(C)OC(C)C5)c4)cc23)CC1",
        "output": "567"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.Cl.Cl.ClCCCl.NC(=O)OCC(N)c1ccccc1C(F)(F)F.O=C(O)Cn1nc(-c2ccc(Cl)cc2)n(Cc2ccccc2F)c1=O.On1nnc2ccccc21>>NC(=O)OCC(NC(=O)Cn1nc(-c2ccc(Cl)cc2)n(Cc2ccccc2F)c1=O)c1ccccc1C(F)(F)F",
        "output": "599"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=C(C)[C@H](CO)CC=C(C)C.CC[C@H](C)C(=O)O.CC[C@H](C)C(=O)OC[C@@H]1CC(=C(C)C)C1(C)C.CO>>C=C(C)[C@@H](CC=C(C)C)COC(=O)[C@@H](C)CC",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCO.Cl.NN.O.O=C1c2ccccc2C(=O)N1[C@@H]1CC[C@@H](OCCc2ccccc2)CC1>>N[C@@H]1CC[C@@H](OCCc2ccccc2)CC1",
        "output": "242"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)O.CCOC(=O)Cn1ccnc(Sc2ccccn2)c1=O.CO.ClCCl.[BH4-].[Li+]>>O=c1c(Sc2ccccn2)nccn1CCO",
        "output": "225"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.COc1c(C)cc(C)c(C=O)c1C.O.[Na+].[OH-]>>COc1c(C)cc(C)c(C=CC(C)=O)c1C",
        "output": "295"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.C[O-].Cc1cc(-c2ccccc2)nnc1Cl.O.[Na+]>>COc1nnc(-c2ccccc2)cc1C",
        "output": "407"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)c1cc(N)n(-c2ccccc2F)n1.O=C(Cl)Oc1ccccc1>>CC(C)(C)c1cc(NC(=O)Oc2ccccc2)n(-c2ccccc2F)n1",
        "output": "700"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C=O.CC(=O)O.Cc1nnc2c(NC3CCNCC3)cc(-c3cc4ccccc4n3Cc3ccccc3)nn12>>Cc1nnc2c(NC3CCN(C)CC3)cc(-c3cc4ccccc4n3Cc3ccccc3)nn12",
        "output": "217"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCNC(=O)N(C)c1cccc(-c2ccc(/C=C(\\CC)C(=O)OCC)cc2)c1.CCO.CCOCC.[Na+].[OH-]>>CCCCCNC(=O)N(C)c1cccc(-c2ccc(/C=C(\\CC)C(=O)O)cc2)c1",
        "output": "122"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCCn2c(nc3cnc4cc(OCc5ccccc5)ccc4c32)C1.Cc1ccc(S(=O)(=O)Cl)cc1.O=C(OO)c1cccc(Cl)c1.[NH4+].[OH-]>>CC(C)(C)OC(=O)N1CCCn2c(nc3c(N)nc4cc(OCc5ccccc5)ccc4c32)C1",
        "output": "959"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=C(O)Cc1ccc(O)cc1.O=[N+]([O-])c1oc2ccc(CBr)cc2c1-c1ccccc1.[Na+].[OH-]>>O=C(O)Cc1ccc(OCc2ccc3oc([N+](=O)[O-])c(-c4ccccc4)c3c2)cc1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CC2CNCCN2C1.CN1CCN(C2CCc3cc(C(=O)O)ccc3C2)CC1.Cl.Cl>>CN1CCN(C2CCc3cc(C(=O)N4CCN5CCCC5C4)ccc3C2)CC1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CC1C(=O)OC2CC3(C)OC3C(O)C(N(C)C)C3=CC(OC3=O)C21.CN(C)C=O.O.c1c[nH]cn1>>CC1C(=O)OC2CC3(C)OC3C(O[Si](C)(C)C(C)(C)C)C(N(C)C)C3=CC(OC3=O)C21",
        "output": "193"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.C[C@H]1Cn2ncc(N3CC(N)CC3=O)c2CN1C(=O)Nc1cc(F)c(F)c(F)c1.ClCCl.O=C(Cl)CCCCl>>C[C@H]1Cn2ncc(N3CC(NC(=O)CCCCl)CC3=O)c2CN1C(=O)Nc1cc(F)c(F)c(F)c1",
        "output": "45"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)S(=O)(=O)NC1CCCCC1(O)c1ccc(O)cc1.N#Cc1ccccc1CBr>>CC(C)S(=O)(=O)NC1CCCCC1(O)c1ccc(OCc2ccccc2C#N)cc1",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@@](F)(CO)C1.CCN(CC)CC.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1CCC[C@@](F)(COS(=O)(=O)C(F)(F)F)C1",
        "output": "582"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC1CCc2c(N3CCN(Cc4ccc([N+](=O)[O-])cc4)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23.[H][H].[Pd]>>CC1CCc2c(N3CCN(Cc4ccc(N)cc4)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23",
        "output": "507"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1CC(=O)CC(c2ccncc2[N+](=O)[O-])O1.CO.NCc1ccccc1.[BH4-].[Li+]>>CC1CC(NCc2ccccc2)CC(c2ccncc2[N+](=O)[O-])O1",
        "output": "589"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(-c3ccc(C(=O)c4ccccc4)cc3)sc2c1.Cl.ClCCl>>O=C(c1ccccc1)c1ccc(-c2sc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCNCC.C[C@@H]1CC[C@@H](C)N1C(=O)c1ccc(-c2ccc(OCCCCl)cc2)cc1>>CCN(CC)CCCOc1ccc(-c2ccc(C(=O)N3[C@H](C)CC[C@H]3C)cc2)cc1",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCn1ncc2c(NC3CCOCC3)c(-c3nc(CN)no3)cnc21.ClC(Cl)Cl.O=C(Cl)CCCCCl>>CCn1ncc2c(NC3CCOCC3)c(-c3nc(CNC(=O)CCCCCl)no3)cnc21",
        "output": "45"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.ClCCl.O=C(O)C1(c2cccs2)CCOCC1.O=S(Cl)Cl>>O=C(Cl)C1(c2cccs2)CCOCC1",
        "output": "53"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.CO[Si](CCCCl)(OC)OC.[N-]=[N+]=[N-].[N-]=[N+]=[N-].[Na+]>>CO[Si](CCCN=[N+]=[N-])(OC)OC",
        "output": "243"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCN(CC)CC.CN(C)C=O.COC(=O)[C@@H](N)CO.Cl.O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)OCc1ccccc1.On1nnc2ccccc21>>COC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1",
        "output": "129"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)OC(=O)Nc2ccc(OCCCCCCBr)cc21.COc1ccc(S)cc1OC>>COc1ccc(SCCCCCCOc2ccc3c(c2)C(C)(C)OC(=O)N3)cc1OC",
        "output": "124"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.NCc1cccc(Oc2ccccc2)c1.O=C(O)c1ccc2ncsc2c1>>O=C(NCc1cccc(Oc2ccccc2)c1)c1ccc2ncsc2c1",
        "output": "753"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)Cn1c(CCl)nc2cnc3cc(Br)ccc3c21.Cc1ccc(S(=O)(=O)Cl)cc1.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.[NH4+].[OH-]>>CC(C)Cn1c(CCl)nc2c(N)nc3cc(Br)ccc3c21",
        "output": "959"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Nc1ccc(C(=O)O)c2c1OCCO2.CC(C)COC(=O)Cl.CCN1CCCC1CN>>CCN1CCCC1CNC(=O)c1ccc(NC(C)=O)c2c1OCCO2",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)C1=CN=c2c(ccc3c2=CN=N3)C1=O.Cl.[Na+].[OH-]>>O=C(O)C1=CN=c2c(ccc3c2=CN=N3)C1=O",
        "output": "122"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCC(CC)CO.N#Cc1c(N)cccc1F.[H-].[Na+]>>CCC(CC)COc1cccc(N)c1C#N",
        "output": "485"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1ccc(C2(NC(=O)C3CC4CC4CN3Cc3cccc(C(F)(F)F)c3)CC2)cc1.O.[Li]O>>O=C(O)c1ccc(C2(NC(=O)C3CC4CC4CN3Cc3cccc(C(F)(F)F)c3)CC2)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.CC#N.CC(C)=O.COc1ccc(-c2ccc3c(c2)CCCC3=O)cc1.ClCCl.O.O=C=O>>O=C1CCCc2cc(-c3ccc(O)cc3)ccc21",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COc1cc([N+](=O)[O-])ccc1-c1cncs1>>COc1cc(N)ccc1-c1cncs1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCCn1cc(C(=O)O)c2cccc(C)c21.Cl.O=C(NCc1cc(C2CCNCC2)c(F)cc1F)C(F)(F)F>>COCCn1cc(C(=O)N2CCC(c3cc(CNC(=O)C(F)(F)F)c(F)cc3F)CC2)c2cccc(C)c21",
        "output": "256"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N[C@H]1C[C@H](O)C1.CI.[H-].[Na+]>>CO[C@@H]1C[C@@H](NC(=O)OC(C)(C)C)C1",
        "output": "140"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCOC(C)=O.Cc1ccc(NC(=O)C(F)(F)F)cc1C(F)(F)F.O.O=C1CCC(=O)N1Br>>O=C(Nc1ccc(CBr)c(C(F)(F)F)c1)C(F)(F)F",
        "output": "29"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)[O-].CC(=O)[O-].COC(=O)c1cc(Br)nc2c1[nH]c1cc(OC)c(Cl)cc12.COc1ccc(B(O)O)cc1.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd+2]>>COC(=O)c1cc(-c2ccc(OC)cc2)nc2c1[nH]c1cc(OC)c(Cl)cc12",
        "output": "869"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COc1ccc(CCc2c(Cc3ccccc3)sc3ccccc23)cc1.ClCCl.ClCCl>>Oc1ccc(CCc2c(Cc3ccccc3)sc3ccccc23)cc1",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.Cc1ccccc1.II.OCCCCCCc1ccccc1.c1c[nH]cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>ICCCCCCc1ccccc1",
        "output": "670"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cl[Sn]Cl.O=[N+]([O-])c1ccccc1S(=O)(=O)Nc1ccc(OCc2ccccc2)c2cccnc12>>Nc1ccccc1S(=O)(=O)Nc1ccc(OCc2ccccc2)c2cccnc12",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N1CCNC[C@H]1C.CC(C)C1=C(C(=O)N2[C@H](C)CC[C@H]2C(=O)O)SC2=N[C@@](C)(c3ccc(Cl)cc3)[C@@H](c3ccc(Cl)cc3)N21.Cl>>CC(=O)N1CCN(C(=O)[C@@H]2CC[C@@H](C)N2C(=O)C2=C(C(C)C)N3C(=N[C@@](C)(c4ccc(Cl)cc4)[C@H]3c3ccc(Cl)cc3)S2)C[C@H]1C",
        "output": "685"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN1C(=O)[C@@H]2[C@@H](C(F)(F)F)OC[C@]2(c2cc([N+](=O)[O-])ccc2F)N=C1NC(=O)OC(C)(C)C.CCO.[H][H].[Pd]>>CCN1C(=O)[C@@H]2[C@@H](C(F)(F)F)OC[C@]2(c2cc(N)ccc2F)N=C1NC(=O)OC(C)(C)C",
        "output": "71"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN1C(=O)CCC(C)(C)c2ccc(N)cc21.CN(C)S(=O)(=O)c1ccccc1Nc1nc(Cl)ncc1Cl>>CCN1C(=O)CCC(C)(C)c2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)N(C)C)n3)cc21",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O.CCOCC.O=C(Cl)OCCl.c1ccncc1>>CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)OCCl",
        "output": "144"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)COc1ccc(CC2SC(=O)NC2=O)cc1.CO.NCC(O)COCc1ccccc1.[BH3-]C#N.[Na+]>>CC(COc1ccc(CC2SC(=O)NC2=O)cc1)NCC(O)COCc1ccccc1",
        "output": "236"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(OCc1ccccc1)C(=O)CNC(=O)NCc1ccc(N)nc1.CO.[Pd]>>CCN(O)C(=O)CNC(=O)NCc1ccc(N)nc1",
        "output": "707"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.COCOc1ccc(C(=O)c2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)c(OCCOC(C)=O)c1.Cl.O.O.[Li+].[OH-]>>COCOc1ccc(C(=O)c2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)c(OCC(=O)O)c1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC1(C)CCC(C)(C)c2cc(C(C(N)=O)C(=O)OCc3ccccc3)ccc21.CCOCC.[Pd]>>CC1(C)CCC(C)(C)c2cc(C(C(N)=O)C(=O)O)ccc21",
        "output": "186"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCCC1=O.COc1ccc(N2CCOCC2)c2sc(NC(=O)c3ccnc(Br)c3)nc12.O=C([O-])[O-].OC1CNC1.[Cs+].[Cs+]>>COc1ccc(N2CCOCC2)c2sc(NC(=O)c3ccnc(N4CC(O)C4)c3)nc12",
        "output": "647"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.Cc1cnc(Cn2c(C)cc(O)c(Cl)c2=O)cn1.Fc1ccc(CBr)c(F)c1.O=C([O-])[O-].[K+].[K+]>>Cc1cnc(Cn2c(C)cc(OCc3ccc(F)cc3F)c(Cl)c2=O)cn1",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCCl.O=S(Cl)Cl.OCc1ccc(Cl)nc1>>ClCc1ccc(Cl)nc1",
        "output": "477"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)CN(CCCOc2ccc(Cl)cc2[N+](=O)[O-])CCC1(O)Cc1ccc(Cl)cc1.CCO.Cl[Sn]Cl.O.O>>CC1(C)CN(CCCOc2ccc(Cl)cc2N)CCC1(O)Cc1ccc(Cl)cc1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CC(O)C(S(=O)(=O)c2ccc(OCc3ccccc3)cc2)C1.ClCCl.O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1>>CC(C)(C)OC(=O)N1CC(=O)C(S(=O)(=O)c2ccc(OCc3ccccc3)cc2)C1",
        "output": "650"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1cc2nc(Cl)nc(N3CCOCC3)c2o1>>CNC(=O)c1cc2nc(Cl)nc(N3CCOCC3)c2o1",
        "output": "714"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.O=C1NC(=O)c2ccccc21.OCCCCCCCCCCCCCCCCCCCCBr.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C1c2ccccc2C(=O)N1CCCCCCCCCCCCCCCCCCCCBr",
        "output": "420"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1ncc(C(F)F)cc1Cl.[BH4-].[Na+]>>OCc1ncc(C(F)F)cc1Cl",
        "output": "711"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CN(C)C=O.Cc1cccc(CCCO)c1O.O=S(Cl)Cl.c1ccncc1>>Cc1cccc(CCCCl)c1O",
        "output": "96"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)COc1ccc(CNC(=O)c2ccc(CNC(=O)OC(C)(C)C)cc2)cc1.O.O.[Li+].[OH-]>>CC(C)(C)OC(=O)NCc1ccc(C(=O)NCc2ccc(OCC(=O)O)cc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1ccc2scc(-c3ccc(O)cc3C)c2c1.ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>COC(=O)c1ccc2scc(-c3ccc(OS(=O)(=O)C(F)(F)F)cc3C)c2c1",
        "output": "731"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(=O)(=O)c1ccc(-c2cc(CCl)on2)cc1.Fc1ccccc1-c1nc2cn[nH]cc-2n1>>CS(=O)(=O)c1ccc(-c2cc(Cn3cc4nc(-c5ccccc5F)nc-4cn3)on2)cc1",
        "output": "997"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(C)=O.CCN.CSc1c(Cl)nc(Cl)nc1Cl.[Na+].[OH-]>>CCNc1nc(Cl)c(SC)c(Cl)n1",
        "output": "544"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc(NS(=O)(=O)c2cccc(Cl)c2)c2c(-c3cccc(CNC(=O)OC(C)(C)C)c3)c(C)sc2n1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(NS(=O)(=O)c2cccc(Cl)c2)c2c(-c3cccc(CN)c3)c(C)sc2n1",
        "output": "793"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cc1ccc(NC(=O)Oc2ccccc2)cn1.Cl.ClCCl.NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1>>CS(=O)(=O)Cc1ccc(NC(=O)NCc2cc(C(F)(F)F)nn2-c2cccc(Cl)c2)cn1",
        "output": "488"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)Nc1ccc(F)cc1.O=C(Cl)CCl>>CC(C)N(C(=O)CCl)c1ccc(F)cc1",
        "output": "160"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)/C=C1\\CNC(=O)c2cc(OC)c(OC)cc21.CO.[Li+].[OH-]>>COc1cc2c(cc1OC)/C(=C/C(=O)O)CNC2=O",
        "output": "122"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCNCc1nc2ccccc2[nH]1.CCOC(C)=O.Cc1ccccc1.O=C(Cl)c1cccc(F)c1F.O=C([O-])O.[Na+]>>CCCCN(Cc1nc2ccccc2[nH]1)C(=O)c1cccc(F)c1F",
        "output": "201"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)c1cnc2n1CCN(C(C)=O)C2.Cl.[Na+].[OH-]>>CC(=O)N1CCn2c(C(=O)O)cnc2C1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrP(Br)Br.ClC(Cl)Cl.O.O=[N+]([O-])c1cc(Cl)ccc1CO>>O=[N+]([O-])c1cc(Cl)ccc1CBr",
        "output": "300"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N[C@@H](C)COc1ccc2nc(-c3ccc(O)c(F)c3)oc2c1.CC1(C)CO1>>CC(=O)N[C@@H](C)COc1ccc2nc(-c3ccc(OCC(C)(C)O)c(F)c3)oc2c1",
        "output": "277"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.O=C(C[C@@H](CC1CCCC1)C(=O)N1N=CC[C@H]1C(=O)Nc1ccc(F)cn1)NOCc1ccccc1.O=C(OO)c1cccc(Cl)c1>>O=C(C[C@@H](CC1CCCC1)C(=O)N1N=CC[C@H]1C(=O)Nc1ccc(F)c[n+]1[O-])NOCc1ccccc1",
        "output": "262"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(N)(CC)C(=O)NC.O=C(O)c1ccc(C2CC2)c(O[C@@H](CCO)C(F)(F)F)n1>>CCC(CC)(NC(=O)c1ccc(C2CC2)c(O[C@@H](CCO)C(F)(F)F)n1)C(=O)NC",
        "output": "738"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CC[Si](Cl)(CC)CC.N#Cc1cnc(N)cc1N[C@@H]1[C@H]2CC[C@H](C2)[C@@H]1CO>>CC[Si](CC)(CC)OC[C@H]1[C@@H]2CC[C@@H](C2)[C@H]1Nc1cc(N)ncc1C#N",
        "output": "193"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)N.Oc1ccc(OCCBr)cc1>>CC(C)NCCOc1ccc(O)cc1",
        "output": "147"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClCCl.Clc1ccc2c(c1)CNCc1nnc([C@@H]3CC[C@@H](c4nsc5ccccc45)CC3)n1-2>>CC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2[C@@H]2CC[C@@H](c3nsc4ccccc34)CC2)C1",
        "output": "240"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)OB(OC(C)C)OC(C)C.CCCCCC.CCOCC.COc1ccc(Br)c2ccccc12.Cl.[Li]CCCC>>COc1ccc(B(O)O)c2ccccc12",
        "output": "832"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Oc1cc(N2CCOCC2)c2ccccc2c1Cl.[H][H].[K+].[OH-].[Pd]>>Oc1cc(N2CCOCC2)c2ccccc2c1",
        "output": "253"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=O.CCN(CC)C(=O)c1ccc(Cn2nc(C(F)(F)F)c3c2CCNC3)cc1.O=CO>>CCN(CC)C(=O)c1ccc(Cn2nc(C(F)(F)F)c3c2CCN(C)C3)cc1",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)CCCC(=O)O.O=S(Cl)Cl>>CC(C)CCCC(=O)Cl",
        "output": "53"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.Cl.ClCCl.Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(C(=O)OC(C)(C)C)C4)n2)cn1>>Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CCNC4)CC3)n2)cn1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CNCCNC.Cc1ccccc1.O.O=C(c1ccccc1)c1ccc(Br)cc1.[C-]#N.[Cu]I.[NH4+].[Na+].[OH-]>>N#Cc1ccc(C(=O)c2ccccc2)cc1",
        "output": "65"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC[SiH](CC)CC.Clc1cccc2[nH]ccc12.O=C(O)C(F)(F)F>>Clc1cccc2c1CCN2",
        "output": "672"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCI.CN(C)C=O.CSc1nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c2c(=O)[nH]1.O.O=C([O-])[O-].[K+].[K+]>>CCn1c(SC)nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c2c1=O",
        "output": "326"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2sc3c(c12)CCC(C(=O)O)C3.CNCCO>>CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2sc3c(c12)CCC(C(=O)N(C)CCO)C3",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)c1cnn(C)c1OC.O.[K+].[OH-]>>COc1c(C(=O)O)cnn1C",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#Cc1cc(Cl)ccc1OCC(=O)OC(C)(C)C.Cc1ccc(S(C)(=O)=O)cc1I>>Cc1ccc(S(C)(=O)=O)cc1C#Cc1cc(Cl)ccc1OCC(=O)OC(C)(C)C",
        "output": "664"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COC(=O)[C@@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1.ClCCl.O=C(Cl)C(=O)Cl>>COC(=O)[C@H]1CC[C@@H](Oc2ccc(C(=O)Cl)cc2)CC1",
        "output": "448"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.Cc1cc(-c2cc[nH]c(=O)n2)ccn1.ClCCCCBr.O.[H-].[Na+]>>Cc1cc(-c2ccn(CCCCCl)c(=O)n2)ccn1",
        "output": "327"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.Cn1cnc(-c2cccc(N)c2)c1-c1cc2c(N)ncnc2s1.O=C=Nc1ccccc1>>Cn1cnc(-c2cccc(NC(=O)Nc3ccccc3)c2)c1-c1cc2c(N)ncnc2s1",
        "output": "473"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CNC.Cc1c(-c2ccn(C[C@H](C)NC(=O)c3csc(Br)n3)n2)ccc(C#N)c1Cl.c1ccncc1>>Cc1c(-c2ccn(C[C@H](C)NC(=O)c3csc(N(C)C)n3)n2)ccc(C#N)c1Cl",
        "output": "657"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.CCOCC.Cl.ClCc1ccc2ccccc2n1.O=C([O-])[O-].O=Cc1ccc(O)cc1.[K+].[K+]>>O=Cc1ccc(OCc2ccc3ccccc3n2)cc1",
        "output": "616"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CO.COC(=O)CCc1cc(NC(=O)C(F)(F)F)c(OCc2ccccc2)c(-c2ccc3c(cnn3C)c2)c1.[Pd]>>COC(=O)CCc1cc(NC(=O)C(F)(F)F)c(O)c(-c2ccc3c(cnn3C)c2)c1",
        "output": "23"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCN(CC[C@H](N)c3ccccc3)CC2)c1.CCCS(=O)(=O)Cl>>CCCS(=O)(=O)N[C@@H](CCN1CCC(c2cccc(NC(=O)C(C)C)c2)CC1)c1ccccc1",
        "output": "742"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cn2cc(N)cc(C(F)(F)F)c2n1.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(Cl)nc1>>Cc1cn2cc(NC(=O)c3ccc(Cl)nc3)cc(C(F)(F)F)c2n1",
        "output": "863"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)COCCN1.Cl.O=C(O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1>>CC1(C)COCCN1C(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1",
        "output": "729"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(C)(C)c1ccc(C=O)cc1.CO.O.O=C1CCCc2ccccc21.[K+].[OH-]>>CC(C)(C)c1ccc(C=C2CCc3ccccc3C2=O)cc1",
        "output": "85"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClC(Cl)Cl.NCC1CCOCC1.O.O=C(O)c1cc(COc2ccc(OC(F)(F)F)cc2)on1.On1nnc2ccccc21>>O=C(NCC1CCOCC1)c1cc(COc2ccc(OC(F)(F)F)cc2)on1",
        "output": "696"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(OCc1ccccc1)[C@@H]1CCCCN1c1nc2cc(C(F)(F)F)ccc2o1.[Li+].[OH-]>>O=C(O)[C@@H]1CCCCN1c1nc2cc(C(F)(F)F)ccc2o1",
        "output": "186"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COc1cc2c(Cl)ncnc2cc1OCCCN1CCN(C)CC1.O=C([O-])[O-].Oc1ccc2cccnc2c1.[K+].[K+].[Na+].[OH-]>>COc1cc2c(Oc3ccc4cccnc4c3)ncnc2cc1OCCCN1CCN(C)CC1",
        "output": "668"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1nc(NC2CCCCC2)c(C)c(C)c1OCc1ccccc1.[Pd]>>Cc1nc(NC2CCCCC2)c(C)c(C)c1O",
        "output": "264"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CC1(N)CS(=O)(=O)C1.CN.CO>>CNC(=O)CC1(N)CS(=O)(=O)C1",
        "output": "64"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CCOC(C)=O.COc1cccc([C@H]2O[C@H](CC(=O)Nc3ccc(C(=O)O)o3)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC.O.c1ccncc1>>COc1cccc([C@H]2O[C@H](CC(=O)Nc3ccc(C(=O)O)o3)C(=O)N(CC(C)(C)COC(C)=O)c3ccc(Cl)cc32)c1OC",
        "output": "126"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.N[C@@H](Cc1ccc2ccccc2c1)C(=O)O.O=C(NCCCl)Nc1ccnc2ccccc12.O=C([O-])O.[Na+].c1ccc(OC2CCNCC2)cc1>>O=C(NCCN1CCC(Oc2ccccc2)CC1)Nc1ccnc2ccccc12",
        "output": "138"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.COc1cc(C=O)cc(Cl)c1O.ClCCl>>O=Cc1cc(O)c(O)c(Cl)c1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.C=CCCC(Br)C1CCN(C(=O)OCc2ccccc2)CC1.CC(C)(C)O.CC(C)=O.CCOC(C)=O.C[N+]1([O-])CCOCC1.O.O=[Os](=O)(=O)=O.[Na+].[O-][I+3]([O-])([O-])[O-]>>O=CCCC(Br)C1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "571"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CC(c1c[nH]c2ccccc12)C(N)C(=O)N1C[C@@H](CN(C)C)Cc2cc(Cl)ccc21.CCN=C=NCCCN(C)C.Cn1c(C(=O)N2CCC(C(=O)O)CC2)cc2ccccc21.O=C([O-])[O-].On1nnc2ccccc21.[Na+].[Na+]>>CC(c1c[nH]c2ccccc12)C(NC(=O)C1CCN(C(=O)c2cc3ccccc3n2C)CC1)C(=O)N1C[C@@H](CN(C)C)Cc2cc(Cl)ccc21",
        "output": "133"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.CCOC(C)(C)c1nc2cc(C(=O)O)cc(C)n2c1CC1CCC(F)(F)CC1.Cl.NC1CCOCC1.O.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CCOC(C)(C)c1nc2cc(C(=O)NC3CCOCC3)cc(C)n2c1CC1CCC(F)(F)CC1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.Fc1ccc(CC2CCNCC2)cc1.O=C(O)c1cc(=O)c2cc(O)ccc2[nH]1>>O=C(c1cc(=O)c2cc(O)ccc2[nH]1)N1CCC(Cc2ccc(F)cc2)CC1",
        "output": "605"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NCCOc1ccccc1.O=C(O)c1cc2cc(Cl)ncc2[nH]1>>O=C(NCCOc1ccccc1)c1cc2cc(Cl)ncc2[nH]1",
        "output": "137"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)P1(=NC(C)(C)C)N(C)CCCN1C.CCS(=O)(=O)c1ccc(CBr)cc1.CN(C)C=O.COC(=O)Cc1c(C)[nH]c2ncccc12>>CCS(=O)(=O)c1ccc(Cn2c(C)c(CC(=O)OC)c3cccnc32)cc1",
        "output": "389"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COc1cc(-c2cc(C(=O)O)c3cc(Br)ccc3n2)cc(OC)c1OC.Cl.Cl.NC(CO)Cc1c[nH]c2ccncc12.O.On1nnc2ccccc21>>COc1cc(-c2cc(C(=O)NC(CO)Cc3c[nH]c4ccncc34)c3cc(Br)ccc3n2)cc(OC)c1OC",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1coc2c1C(=O)C(C)(C)CC2.COC(=O)c1coc2c1C(=O)N(C)C(C)(C)C2>>CN1C(=O)c2c(C(=O)O)coc2CC1(C)C",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.CCOC(=O)CC1c2cccc(C#N)c2OCCN1C(=O)OC(C)(C)C.CCOCC.CO.[BH4-].[Li+]>>CC(C)(C)OC(=O)N1CCOc2c(C#N)cccc2C1CCO",
        "output": "225"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1cccc(OCc2ccccc2)c1.O=C(Cl)c1ccccc1[N+](=O)[O-]>>O=C(Nc1cccc(OCc2ccccc2)c1)c1ccccc1[N+](=O)[O-]",
        "output": "11"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(NC(=O)c1cccc(Oc2ccc([N+](=O)[O-])cc2Cl)c1)C(N)=O.CCN(CC)CC.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C#N)NC(=O)c1cccc(Oc2ccc([N+](=O)[O-])cc2Cl)c1",
        "output": "172"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.O=C1CCNC(Cc2ccccc2)C1>>CC(C)(C)OC(=O)N1CCC(=O)CC1Cc1ccccc1",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC.CCN(C(C)C)C(C)C.COC1=CC(=O)[C@H]2C(=O)[C@]1(CC=C(C)C)C[C@H](O)[C@@]2(C)CCC=C(C)C.COCCOC.COCCl>>COCO[C@H]1C[C@@]2(CC=C(C)C)C(=O)[C@H](C(=O)C=C2OC)[C@]1(C)CCC=C(C)C",
        "output": "598"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].O=C([O-])[O-].[Na+].[Na+].[Na+].c1cnc2c(c1)CC1(CN3CCC1CC3)O2>>Brc1cnc2c(c1)CC1(CN3CCC1CC3)O2",
        "output": "292"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOCC.Cc1cccc(C(=O)O)c1C>>Cc1cccc(CO)c1C",
        "output": "72"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CO.COc1ccc2ncc3c(c2n1)CC(C[C@@H]1CC[C@@H](N)CC1)O3.ClCCCl.O=Cc1ccc2c(c1)NC(=O)CO2.[BH3-]C#N.[Na+]>>COc1ccc2ncc3c(c2n1)CC(C[C@@H]1CC[C@@H](NCc2ccc4c(c2)NC(=O)CO4)CC1)O3",
        "output": "468"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1c(-c2cccc(C(F)F)c2)c(=O)c(C(=O)O)cn1C1CCCC1.Cc1nnc(CN)o1.F[P-](F)(F)(F)(F)F>>Cc1nnc(CNC(=O)c2cn(C3CCCC3)c(C)c(-c3cccc(C(F)F)c3)c2=O)o1",
        "output": "674"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC1(C)C=Cc2cc(B(O)O)ccc2O1.CCCc1nc(C)[nH]c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCN(CC)CC.CCOC(C)=O.ClCCl.[Cu+2].c1ccncc1>>CCCc1nc(C)n(-c2ccc3c(c2)C=CC(C)(C)O3)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "962"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.Cl.Cl.Nc1nc2[nH]nc(-c3ccccc3)c2s1.O=C(Cl)c1ccncc1.[Na+].[OH-].c1ccncc1>>O=C(Nc1nc2[nH]nc(-c3ccccc3)c2s1)c1ccncc1",
        "output": "673"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1[nH]cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)c(=O)c1-c1cccc(C(F)F)c1.N#Cc1ccc(CBr)c(F)c1>>Cc1c(-c2cccc(C(F)F)c2)c(=O)c(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cn1Cc1ccc(C#N)cc1F",
        "output": "528"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.[N-]=[N+]=NCc1cccc(OCC(F)(F)F)n1.[Pd]>>NCc1cccc(OCC(F)(F)F)n1",
        "output": "89"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CC(=O)Nc1cc(F)c(Oc2ccnc(N)c2)cc1F.O=C(CC(=O)Nc1ccc(Oc2cc(Nc3ccc(OCc4ccccc4)cc3)ncn2)c(F)c1)Nc1ccc(F)cc1>>Nc1cc(Oc2cc(F)c(NC(=O)CC(=O)O)cc2F)ccn1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C(COC(=O)Cc1ccc([N+](=O)[O-])c(C)c1)(C(=O)OCC)c1ccccc1.CO.[C].[Pd]>>CCOC(=O)C(COC(=O)Cc1ccc(N)c(C)c1)(C(=O)OCC)c1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CO[C@H]1C[C@@H](NC(=O)OCc2ccccc2)CC[C@@H]1N.ClCCl>>CO[C@H]1C[C@@H](NC(=O)OCc2ccccc2)CC[C@@H]1NC(=O)OC(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrBr.CNC(=O)/C(=N/OC)c1ccccc1Oc1ccccc1.ClC(Cl)(Cl)Cl>>CNC(=O)/C(=N/OC)c1ccccc1Oc1ccc(Br)cc1",
        "output": "98"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1.N>>NC(=O)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1",
        "output": "432"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCN(Cc2ccc(C(=O)[O-])cc2C(F)(F)F)CC1.CCS(=O)(=O)c1ccc(Cl)cc1CN.Cl.O=C(O)c1cc(C(F)(F)F)ccn1>>CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(C(F)(F)F)ccn1",
        "output": "905"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCCN.Cc1ccc(S(=O)(=O)OCC2COc3c(F)cc(F)cc3O2)cc1>>CCCNCC1COc2c(F)cc(F)cc2O1",
        "output": "853"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br.Br.Nc1cnc2c(n1)CCNCC2.O=C(Cl)c1ccc(Cl)cc1>>Nc1cnc2c(n1)CCN(C(=O)c1ccc(Cl)cc1)CC2",
        "output": "201"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCc1nc2cnc3ccccc3c2n1CC1(N)CCCCC1.CN(C)c1ccncc1.CS(=O)(=O)Cl.ClCCl.c1ccncc1>>CCOCc1nc2cnc3ccccc3c2n1CC1(NS(C)(=O)=O)CCCCC1",
        "output": "493"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccc(OCCN2CCOCC2)c(Br)c1.[H][H].[Ni]>>Nc1ccc(OCCN2CCOCC2)c(Br)c1",
        "output": "202"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)C1(S(=O)(=O)c2ccc(OC)cc2)CCN(C(C)C)CC1.CO.[Na+].[OH-]>>COc1ccc(S(=O)(=O)C2(C(=O)O)CCN(C(C)C)CC2)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)CN(CC(OCC)OCC)S(=O)(=O)c1ccc2cc(Cl)ccc2c1.ClC(Cl)Cl.O.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CCOC(=O)CN(CC=O)S(=O)(=O)c1ccc2cc(Cl)ccc2c1",
        "output": "409"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=[N+]([O-])c1c(F)c(Br)cc(-c2ccccn2)c1I.[Cl-].[Fe].[NH4+]>>Nc1c(F)c(Br)cc(-c2ccccn2)c1I",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)NS(=O)(=O)Cl.CCN(CC)CC.CSc1ccc(N)cc1.ClCCl>>CSc1ccc(NS(=O)(=O)NC(C)C)cc1",
        "output": "395"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC(c2ncc(F)cc2Br)C1.CCN(CC)CC.CS(C)=O.O.OCC1CCNCC1>>CC(C)(C)OC(=O)N1CC(c2ncc(F)cc2N2CCC(CO)CC2)C1",
        "output": "597"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)[Si](C)(C)OCCN1CCN(c2ccc3[nH]ccc3c2)CC1.CN(C)c1ccncc1>>CC(C)(C)OC(=O)n1ccc2cc(N3CCN(CCO[Si](C)(C)C(C)(C)C)CC3)ccc21",
        "output": "748"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)N1Cc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Oc4ccccc4)cc3)c2C1.CC(O)CN.C[C@H]1COCCN1c1nc2c(c(-c3ccc(NC(=O)NCCO)cc3)n1)CN(C(=O)OC(C)(C)C)C2>>CC(O)CNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)nc3c2CN(C(C)C)C3)cc1",
        "output": "488"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CC1(O)CCC(NC(=O)c2cnc(Cl)cc2NC2CC2)CC1.Nc1ccc2ncsc2c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Na+].[Na+].[Pd].[Pd]>>CC1(O)CCC(NC(=O)c2cnc(Nc3ccc4ncsc4c3)cc2NC2CC2)CC1",
        "output": "434"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NC1CNC1.CN(C)C=O.CN1CCOCC1.F[P-](F)(F)(F)(F)F.O=C(O)c1c(F)cc(F)cc1Nc1ccc(I)cc1F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CC(C)(C)OC(=O)NC1CN(C(=O)c2c(F)cc(F)cc2Nc2ccc(I)cc2F)C1",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=O.CCOC(=O)CCCBr.O=C([O-])[O-].SC1c2ccccc2COc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc21.[K+].[K+]>>CCOC(=O)CCCSC1c2ccccc2COc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc21",
        "output": "185"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN1CCNCC1.CO.O.O=[N+]([O-])c1ccc(F)c(C(F)(F)F)c1>>CN1CCN(c2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1",
        "output": "26"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.Cc1ccc(S(=O)(=O)OCCCc2c[nH]c3ccc(C#N)cc23)cc1.O=C([O-])[O-].O=C1CCCCN1c1ccc(N2CCNCC2)cc1.[I-].[K+].[K+].[K+]>>N#Cc1ccc2[nH]cc(CCCN3CCN(c4ccc(N5CCCCC5=O)cc4)CC3)c2c1",
        "output": "429"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3ccc([N+](=O)[O-])c(C)c3)S(C)(=O)=O)c(C3CC3)cc12.[Pd]>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3ccc(N)c(C)c3)S(C)(=O)=O)c(C3CC3)cc12",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2ccc(C#N)c(-c3cccc(C=O)c3)c2)c1.CN1CCNCC1.ClCCl.[Na+]>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2ccc(C#N)c(-c3cccc(CN4CCN(C)CC4)c3)c2)c1",
        "output": "567"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.Nc1ccc(Br)cn1.O.O=C(O)[C@H](CC1CCCC1)c1ccc(Cl)c(Cl)c1.O=C1CCC(=O)N1Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccncc1>>O=C(Nc1ccc(Br)cn1)[C@H](CC1CCCC1)c1ccc(Cl)c(Cl)c1",
        "output": "368"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(N)CO.CS(=O)(=O)Nn1c(=O)[nH]c2cc([N+](=O)[O-])c(F)cc2c1=O>>CC(C)(CO)Nc1cc2c(=O)n(NS(C)(=O)=O)c(=O)[nH]c2cc1[N+](=O)[O-]",
        "output": "572"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.COCCBr.CS(=O)(=O)Oc1cccc(C2CCNCC2)c1F.O=C([O-])[O-].OC(c1cccc(C2CCNCC2)c1F)C(F)(F)F.[K+].[K+]>>COCCN1CCC(c2cccc(C(O)C(F)(F)F)c2F)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.Cc1cc(=O)oc2cc(O)ccc12.O=C(Cl)c1ccccc1>>Cc1cc(=O)oc2cc(OC(=O)c3ccccc3)ccc12",
        "output": "482"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CC[C@@H]1NC(=O)C[C@H]1O[Si](C)(C)C(C)(C)C.COc1cc(Br)ccc1C#N.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>CC[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)CC(=O)N1c1ccc(C#N)c(OC)c1",
        "output": "809"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.COc1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)N[C@@H]4CCNC4)c(C)[nH]c23)c1.Cl>>COc1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)N[C@@H]4CCN(C(C)=O)C4)c(C)[nH]c23)c1",
        "output": "125"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#Cc1ccc(S(C)(=O)=O)cc1.CCN(CC)CC.CN(C)C=O.COC(=O)COc1ccc(OCC#Cc2cc(Br)cc(C#CCN3CCOCC3)c2)cc1C.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>COC(=O)COc1ccc(OCC#Cc2cc(C#CCN3CCOCC3)cc(C#Cc3ccc(S(C)(=O)=O)cc3)c2)cc1C",
        "output": "659"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C1CCNC1.Cc1cccc2c(=O)[nH]c(Cl)cc12>>Cc1cccc2c(=O)[nH]c(N3CCC(N(C)C)C3)cc12",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1c(N)cc(C(C)(C)C)cc1NS(C)(=O)=O.O=C(O)c1ccc(Cl)c(-n2cc(-c3cccnc3)nn2)c1>>COc1c(NC(=O)c2ccc(Cl)c(-n3cc(-c4cccnc4)nn3)c2)cc(C(C)(C)C)cc1NS(C)(=O)=O",
        "output": "50"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.COc1cc(C=O)c(OC)cc1C.Cl.NO.c1ccncc1>>COc1cc(C#N)c(OC)cc1C",
        "output": "453"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCC1CCNC1.Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)O)cn2)c1O>>COCC1CCN(C(=O)c2ccc(-n3ncc(-c4ccc(C#N)cc4C)c3O)nc2)C1",
        "output": "256"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC1CCN(c2ccc(-c3noc(=O)[nH]3)c(Cl)c2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc21.ClCCl.O=C(O)C(F)(F)F>>NC1CCN(c2ccc(-c3noc(=O)[nH]3)c(Cl)c2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc21",
        "output": "793"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C[Si](C)(C)CCO.ClCCl.O.O=C(Cl)c1cccc(S(=O)(=O)Cl)c1.c1ccncc1>>C[Si](C)(C)CCOC(=O)c1cccc(S(=O)(=O)Cl)c1",
        "output": "51"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.O=[Mn]=O.OCc1cc(Cl)cc(-c2ccccn2)c1>>O=Cc1cc(Cl)cc(-c2ccccn2)c1",
        "output": "179"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClC(Cl)Cl.ClCCl.O=C(Nc1ccc(Cl)cn1)c1oc2ccccc2c1NC(=O)C1CCNCC1>>CC(=O)N1CCC(C(=O)Nc2c(C(=O)Nc3ccc(Cl)cn3)oc3ccccc23)CC1",
        "output": "125"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCC(O)c1cccc(O)c1.CCO.ClCC1CO1.O.[K+].[OH-]>>CCCCCC(O)c1cccc(OCC2CO2)c1",
        "output": "15"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.C[O-].Cc1c(N2CCN(C(C)C)CC2)ccc([N+](=O)[O-])c1Cl.O.[Na+]>>COc1c([N+](=O)[O-])ccc(N2CCN(C(C)C)CC2)c1C",
        "output": "57"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br.CC(=O)O.CSc1cc(N)ccc1C.O.O=N[O-].O=S(=O)(O)O.[Cu]Br.[Na+]>>CSc1cc(Br)ccc1C",
        "output": "373"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.O=C1CCc2cc3c(c(Cl)c2N1)CCNCC3>>CC(C)(C)OC(=O)N1CCc2cc3c(c(Cl)c2CC1)NC(=O)CC3",
        "output": "694"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(C(Cc2ccc(-c4ccc(C(F)(F)F)cn4)cc2)C(N)=O)n3C)nc1.ClCCl.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(C(C#N)Cc2ccc(-c4ccc(C(F)(F)F)cn4)cc2)n3C)nc1",
        "output": "172"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)NCC[C@]1(c2ccc(F)cc2)CCN([C@@H](C)c2ccc(-c3ccc(F)cc3F)cc2)C(=O)O1.CI.[H-].[Na+]>>CC(=O)N(C)CC[C@]1(c2ccc(F)cc2)CCN([C@@H](C)c2ccc(-c3ccc(F)cc3F)cc2)C(=O)O1",
        "output": "83"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCC1CC(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(Br)cn2)CC(Cc2ccccc2)N1C(=O)C1CCC(OC(C)=O)CC1.Cl.O>>CCC1CC(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(Br)cn2)CC(Cc2ccccc2)N1C(=O)C1CCC(O)CC1",
        "output": "325"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCCBr.CCO.Cc1cc(Br)c(O)c(Br)c1.[K+].[OH-]>>Cc1cc(Br)c(OCCBr)c(Br)c1",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cc(-c2ccc(C(F)(F)F)cc2)c(C(N)=O)cn1.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cc(-c2ccc(C(F)(F)F)cc2)c(C#N)cn1",
        "output": "624"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "B.C1CCOC1.N#CCc1ccsc1Br>>NCCc1ccsc1Br",
        "output": "246"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)C1CC1>>CCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)C1CC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)c1ncc(OCC(=O)O)cc1Cl.CN1CCOCC1.CS(=O)(=O)Nc1ccc(CN)cc1F.Cl>>CC(C)(C)c1ncc(OCC(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1Cl",
        "output": "599"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](O)[C@H](F)C1.CC(C)(C)[O-].N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1F.[K+]>>CC(C)(C)OC(=O)N1CC[C@H](Oc2ccc(-c3ncnc(Nc4ccc(N5CCN(C6COC6)CC5)cc4)n3)cc2C#N)[C@H](F)C1",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1cnc(SC)nc1-c1ccccc1Br.Cl.ClCCl.O>>CSc1ncc(C(=O)O)c(-c2ccccc2Br)n1",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N[C@H](CCc1ccccc1)C(=O)O.CCN(C(C)C)C(C)C.CCOC(=O)C(C#N)=NOC(N1CCOCC1)=[N+](C)C.COc1ccc(C2=NN(C3CCNCC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+]>>COc1ccc(C2=NN(C3CCN(C(=O)[C@@H](CCc4ccccc4)NC(=O)OC(C)(C)C)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=C(O)CC1NCCc2ccccc21.O=S(=O)(O)O>>COC(=O)CC1NCCc2ccccc21",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOCC.CS(=O)(=O)Cl.ClCCl.OCC1COc2ccc(Oc3ccccc3)cc2O1>>CS(=O)(=O)OCC1COc2ccc(Oc3ccccc3)cc2O1",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(=O)Nc1cc(O)c2cc(Br)ccc2n1.CCI.O=C([O-])[O-].[K+].[K+]>>CCOc1cc(NC(C)=O)nc2ccc(Br)cc12",
        "output": "198"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCO.Cl.NO.O=C(CN1CCCC1)c1ccc(OC(F)(F)F)cc1>>ON=C(CN1CCCC1)c1ccc(OC(F)(F)F)cc1",
        "output": "212"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)CCCC(C)CCO.CCCCCCCCCCBr.CCCC[N+](CCCC)(CCCC)CCCC.[Br-].[Na+].[OH-]>>CCCCCCCCCCOCCC(C)CCCC(C)C",
        "output": "95"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOc1ccc(C)nc1C(=O)O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.FC(F)(F)c1ccc(NC[C@@H]2C[C@H]3C[C@H]3CN2)nc1.F[B-](F)(F)F>>CCOc1ccc(C)nc1C(=O)N1C[C@@H]2C[C@@H]2C[C@H]1CNc1ccc(C(F)(F)F)cn1",
        "output": "605"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(CC)CC.CN(C)C=O.Cc1cccc2ccc(-n3cc(C(N)=O)ccc3=O)nc12.O=C(Cl)C(=O)Cl>>Cc1cccc2ccc(-n3cc(C#N)ccc3=O)nc12",
        "output": "624"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1cc(-c2cnco2)cc(-c2cnco2)c1.[Pd]>>Nc1cc(-c2cnco2)cc(-c2cnco2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.COc1cc(C)c(S(=O)(=O)N(Cc2ccc3c(c2)OCO3)[C@H](CNS(C)(=O)=O)C(=O)NOCc2ccccc2)c(C)c1.[Pd]>>COc1cc(C)c(S(=O)(=O)N(Cc2ccc3c(c2)OCO3)[C@H](CNS(C)(=O)=O)C(=O)NO)c(C)c1",
        "output": "707"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)O.CCOC(=O)CC(C(=O)OCC)n1ccc(=O)[nH]c1=O.[BH4-].[Na+]>>CCOC(=O)CC(CO)n1ccc(=O)[nH]c1=O",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClC(Cl)Cl.O=C([O-])[O-].O=S(Cl)Cl.O=c1c(CCc2ccccc2)nc2c(n1CCO)CCCC2.[K+].[K+]>>O=c1c(CCc2ccccc2)nc2c(n1CCCl)CCCC2",
        "output": "96"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)COc1ccc(OC/C=C(/c2ccc(Cl)cc2)c2ccc(C#CCN3CCC(CO)CC3)cc2)cc1C.Cl.O.O.[Cl-].[Li+].[NH4+].[OH-]>>Cc1cc(OC/C=C(/c2ccc(Cl)cc2)c2ccc(C#CCN3CCC(CO)CC3)cc2)ccc1OCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COc1c(O[C@@H]2CCC[C@H](N)C2)ccc2[nH]ncc12.Cl.O.On1nnc2ccccc21>>CCC(=O)N[C@H]1CCC[C@@H](Oc2ccc3[nH]ncc3c2OC)C1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(C)=O.CN(CCO)c1c(S(=O)(=O)C(F)(F)F)c(C#N)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl.Cc1ccc(S(=O)(=O)Cl)cc1.[Cl-].[H-].[NH4+].[Na+]>>Cc1ccc(S(=O)(=O)OCCN(C)c2c(S(=O)(=O)C(F)(F)F)c(C#N)nn2-c2c(Cl)cc(C(F)(F)F)cc2Cl)cc1",
        "output": "197"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.CCN(C(C)C)C(C)C.CCOC(=O)C1(C(N)=O)CCNCC1.Cl.ClCCl>>CCOC(=O)C1(C(N)=O)CCN(C(C)=O)CC1",
        "output": "369"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(S(N)(=O)=O)cc1[N+](=O)[O-].[Ni]>>COc1ccc(S(N)(=O)=O)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOc1ccc(CCl)cc1[N+](=O)[O-].CNC>>CCOc1ccc(CN(C)C)cc1[N+](=O)[O-]",
        "output": "156"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNCC1.CCOCC.CCc1nc2ccccc2c(=O)n1-c1ccc(OCCCCl)c(Br)c1>>CCc1nc2ccccc2c(=O)n1-c1ccc(OCCCN2CCCCC2)c(Br)c1",
        "output": "138"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)CCN.O=C(Nc1cccc(C(F)(F)F)c1)c1ccccc1NCc1ccnc(Br)c1.c1ccncc1>>CN(C)CCNc1cc(CNc2ccccc2C(=O)Nc2cccc(C(F)(F)F)c2)ccn1",
        "output": "715"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.Cc1ccc(C[Se]c2ccccc2C(=O)O)cc1.ClCCl.Nc1ccccc1.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>>Cc1ccc(C[Se]c2ccccc2C(=O)Nc2ccccc2)cc1",
        "output": "50"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CCn1nc(OC)c(C2CCN(C(=O)OC(C)(C)C)CC2)c1C>>CCn1nc(OC)c(C2CCNCC2)c1C",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCN(CCC)CCCc1nc2ccc(C#N)cc2n1CCC.CCO.[Na+].[Ni].[OH-]>>CCCN(CCC)CCCc1nc2ccc(CN)cc2n1CCC",
        "output": "175"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.Cc1ccc(S(=O)(=O)n2ccc3nc4cnc5ccccc5c4n32)cc1.ClC(Cl)Cl.ClCCCl.O.O=C(OO)c1cccc(Cl)c1.[NH4+].[OH-]>>Cc1ccc(S(=O)(=O)n2ccc3nc4c(N)nc5ccccc5c4n32)cc1",
        "output": "959"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1.O.O=C(O)c1ccc(Cl)s1>>O=C(NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1)c1ccc(Cl)s1",
        "output": "736"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCC(=O)Cl.ClCCl.Cn1nnnc1C(=NOCc1cccc(CN)n1)c1ccccc1>>CCCCCC(=O)NCc1cccc(CON=C(c2ccccc2)c2nnnn2C)n1",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=O.Cc1nccc(N2CCNCC2)n1.O=C(Cl)c1ccccc1.O=C([O-])[O-].[K+].[K+]>>Cc1nccc(N2CCN(C(=O)c3ccccc3)CC2)n1",
        "output": "201"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc(OC)c(OCCCCl)c1.Cl.[Na+].[OH-]>>COc1ccc(C(=O)O)cc1OCCCCl",
        "output": "222"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.N.O=C(O)Cn1nnnc1S>>NC(=O)Cn1nnnc1S",
        "output": "313"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOc1ccc(N(C(=O)OC(C)(C)C)c2c(CCCO[Si](C)(C)C(C)(C)C)c(N[C@H]3CCCN(C(=O)OC(C)(C)C)C3)nc3ccnn23)cc1.[F-]>>CCOc1ccc(N(C(=O)OC(C)(C)C)c2c(CCCO)c(N[C@H]3CCCN(C(=O)OC(C)(C)C)C3)nc3ccnn23)cc1",
        "output": "708"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)CC(NC(=O)OC(C)(C)C)c1ccccc1Cl>>CC(C)(C)OC(=O)NC(CCO)c1ccccc1Cl",
        "output": "343"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COC(=O)c1c(F)cccc1Oc1nc(OC)cc(OC)n1.O.[Na+].[OH-]>>COc1cc(OC)nc(Oc2cccc(F)c2C(=O)O)n1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.Cl.OCCCN1CCCCC1.Oc1ccc(-c2nc(CN3CCCCC3)co2)cc1F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Fc1cc(-c2nc(CN3CCCCC3)co2)ccc1OCCCN1CCCCC1",
        "output": "478"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=C[C@H]1OC(c2ccncc2[N+](=O)[O-])=C[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]1O[Si](C(C)C)(C(C)C)C(C)C.CC(=O)O.CCOC(C)=O.[Fe]>>C=C[C@H]1OC(c2ccncc2N)=C[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]1O[Si](C(C)C)(C(C)C)C(C)C",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCN(c1cccc2c1CC=CC(CO)Cc1cc(C)nc(OC)c1CNC2=O)C1CCOCC1.CO.Cl.O=C([O-])C(F)(F)F>>CCN(c1cccc2c1CC=CC(CO)Cc1cc(C)[nH]c(=O)c1CNC2=O)C1CCOCC1",
        "output": "758"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(C)C=O.COc1ccc2ncc(=O)n(CCC=O)c2n1.N[C@H]1CC(=O)N(c2ccc3c(n2)NC(=O)CO3)C1.O=C([O-])O.[Na+].[Na+]>>COc1ccc2ncc(=O)n(CCCN[C@H]3CC(=O)N(c4ccc5c(n4)NC(=O)CO5)C3)c2n1",
        "output": "426"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1ccc(O)cc1.Clc1ccc(OCCCCCCCBr)cc1.[Na]>>CCOC(=O)c1ccc(OCCCCCCCOc2ccc(Cl)cc2)cc1",
        "output": "385"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.Clc1cc(Cl)ncn1.NC[C@H](O)c1ccccc1.O=C([O-])O.[Na+]>>O[C@@H](CNc1cc(Cl)ncn1)c1ccccc1",
        "output": "166"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.Cc1ccn2ncnc(Oc3ccc([N+](=O)[O-])cc3F)c12.[Cl-].[NH4+].[Zn]>>Cc1ccn2ncnc(Oc3ccc(N)cc3F)c12",
        "output": "335"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1.ClCCCl.O=C(C1CNC1)N1CCCC1.[Na+]>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CC(C(=O)N4CCCC4)C3)n(C)c2n1",
        "output": "944"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCN1C(=O)N(N=Cc2ccccc2)C2CC(=O)CC21.CO.[BH4-].[Na+]>>CCCN1C(=O)N(N=Cc2ccccc2)C2CC(O)CC21",
        "output": "91"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.CC(Cl)Cl.N#Cc1cnc2c(Cl)cc(NCc3cn(C4CCCNCC4)nn3)cc2c1Nc1ccc(F)c(Cl)c1.[Na+]>>CC(C)N1CCCC(n2cc(CNc3cc(Cl)c4ncc(C#N)c(Nc5ccc(F)c(Cl)c5)c4c3)nn2)CC1",
        "output": "187"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1nn(Cc2ccc(OC)cc2)cc1NC(C)=O.O.[Li+].[OH-]>>COc1ccc(Cn2cc(NC(C)=O)c(C(=O)O)n2)cc1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOP(=O)(CCN)OCC.CCc1c(C)c2c(c(OCC[Si](C)(C)C)c1CC=O)C(=O)OC2.CN(C)C=O.O=C(O)C(=O)O.[Na+]>>CCOP(=O)(CCNCCc1c(CC)c(C)c2c(c1OCC[Si](C)(C)C)C(=O)OC2)OCC",
        "output": "426"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N(C)C.Cc1cc(-c2cc3ncccc3c(Cl)n2)ccc1N(C)C.O=C1CC(CO)CN1.[H-].[Na+]>>Cc1cc(-c2cc3ncccc3c(OCC3CNC(=O)C3)n2)ccc1N(C)C",
        "output": "461"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)c1ccc(-n2c3ccccc3c3c(-c4ccc(C#N)nc4)cccc32)cc1NCCCO.Cl>>N#Cc1ccc(-c2cccc3c2c2ccccc2n3-c2ccc(C(=O)O)c(NCCCO)c2)cn1",
        "output": "752"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.N#Cc1ccc(F)cc1Cl.O=C([O-])[O-].O=S1(=O)CCN2CCCC(c3ccc(O)cc3)C2=N1.[K+].[K+]>>N#Cc1ccc(Oc2ccc(C3CCCN4CCS(=O)(=O)N=C34)cc2)cc1Cl",
        "output": "564"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)C(NCCCNC(=O)OC(C)(C)C)c1nc2ncccc2c(=O)n1Cc1ccccc1.CCN(C(C)C)C(C)C.Cc1ccc(C(=O)Cl)cc1.Cc1ccc(C(=O)N(CCCNC(=O)OC(C)(C)C)C(c2nc3ncccc3c(=O)n2Cc2ccccc2)C(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(C(=O)N(CCCN)C(c2nc3ncccc3c(=O)n2Cc2ccccc2)C(C)C)cc1",
        "output": "538"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CO.CS[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1.O.O=S([O-])OO.[K+]>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](S(C)(=O)=O)CC1",
        "output": "847"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1ccc2[nH]ncc2c1C.ClCCl.O=C([O-])O.[Na+]>>Cc1c(O)ccc2[nH]ncc12",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(-c2cn(-c3ccncc3)c3cc(N4CCN(C(=O)OC(C)(C)C)CC4)ccc23)cc1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(-c2cn(-c3ccncc3)c3cc(N4CCNCC4)ccc23)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)COCC(CO)O1.CS(=O)(=O)Cl.ClCCl>>CC1(C)COCC(COS(C)(=O)=O)O1",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CC1.CC#N.CCOC(=O)/C=C/c1ccc(N(C(=O)OC(C)(C)C)[C@@H]2CCNC2)nc1.CCOC(C)=O.O.O=C([O-])O.O=C([O-])O.[I-].[K+].[K+].[Na+]>>CCOC(=O)/C=C/c1ccc(N(C(=O)OC(C)(C)C)[C@@H]2CCN(CC3CC3)C2)nc1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)Cc1cc(F)c2nc(Nc3cc(F)ccc3C)oc2c1.CO.Cl.[Na+].[OH-]>>Cc1ccc(F)cc1Nc1nc2c(F)cc(CC(=O)O)cc2o1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc(Nc2cn(C3CCCC3)c3c(C#N)cnc(OC)c23)c1.O.[Na+].[OH-]>>COc1ncc(C#N)c2c1c(Nc1cccc(C(=O)O)c1)cn2C1CCCC1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C(CCCOC1CCCCO1)P(=O)(OCC)OCC.CO>>CCOC(=O)C(CCCO)P(=O)(OCC)OCC",
        "output": "543"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.CCOC(C)=O.CNCC1CCOCC1.Cl.O=C(O)C1CC(O)(c2ccc(CN3CCCC3)c(Cl)c2)C1.[Na+].[OH-]>>CN(CC1CCOCC1)C(=O)C1CC(O)(c2ccc(CN3CCCC3)c(Cl)c2)C1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCCN(C(=O)Nc1ccc(C(=O)OCC)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C.CCO.Cl.O.[K+].[OH-]>>CCCCCN(C(=O)Nc1ccc(C(=O)O)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C",
        "output": "5"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CCCCC1.Nc1nc(Cl)cc(-c2cc(Cl)ccc2O)n1>>Nc1nc(Cl)cc(-c2cc(Cl)ccc2OCC2CCCCC2)n1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(CC(=O)O)NC(=O)OC(C)(C)C.NC1CCc2ccccc2NC1=O>>CC(C)(CC(=O)NC1CCc2ccccc2NC1=O)NC(=O)OC(C)(C)C",
        "output": "133"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Cc1cc(C(=O)N(c2ccccc2)c2ccc(O[Si](C)(C)C(C)(C)C)cc2)cn1-c1cc(C(F)(F)F)ccc1C(=O)N1Cc2ccccc2C[C@H]1CN(C)C.ClCCl.[K+].[OH-]>>Cc1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)cn1-c1cc(C(F)(F)F)ccc1C(=O)N1Cc2ccccc2C[C@H]1CN(C)C",
        "output": "754"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)N(C)C.ClC(Cl)Cl.Fc1cnc(Cl)cc1-c1ccc(C(F)(F)F)nc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[C-]#N.[C-]#N.[Fe+2].[Pd].[Pd].[Zn+2].[Zn].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>N#Cc1cc(-c2ccc(C(F)(F)F)nc2)c(F)cn1",
        "output": "726"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N[C@@H]1CCN(C(=O)c2nc3c(C(F)(F)F)cc(-c4ccoc4)cn3c2Cl)C1.O=C(O)CCCl>>O=C(CCCl)N[C@@H]1CCN(C(=O)c2nc3c(C(F)(F)F)cc(-c4ccoc4)cn3c2Cl)C1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)[Si](C)(C)Oc1ccc2nc(C=O)ccc2c1.CCOC(=O)C1CCNCC1.ClCCCl.[Na+]>>CCOC(=O)C1CCN(Cc2ccc3cc(O[Si](C)(C)C(C)(C)C)ccc3n2)CC1",
        "output": "829"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.ClCCl.Nc1ccccc1.O=C(Cl)c1ccc(Br)cc1>>O=C(Nc1ccccc1)c1ccc(Br)cc1",
        "output": "11"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Nc1cc([N+](=O)[O-])ccc1O.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)Nc1cc([N+](=O)[O-])ccc1O",
        "output": "473"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3[C@H]21.[Na+].[OH-]>>O=C1CCc2c(Oc3ccc4c(c3)[C@@H]3[C@H](O4)[C@H]3C(=O)O)ccnc2N1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOP(=O)(CCCCCCCCCCCCCCCCCCCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)OCC.C[Si](C)(C)Br.ClCCl>>O=P(O)(O)CCCCCCCCCCCCCCCCCCCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F",
        "output": "535"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1=COCCC1.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.O.OCc1ccc(Br)c2cccnc12.c1cc[nH+]cc1>>Brc1ccc(COC2CCCCO2)c2ncccc12",
        "output": "141"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[Si](C)(C)Oc1ccc(N)cc1.N#Cc1ccc([N+](=O)[O-])c(Br)c1>>CC(C)(C)[Si](C)(C)Oc1ccc(Nc2cc(C#N)ccc2[N+](=O)[O-])cc1",
        "output": "405"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C.CCC(C)=O.O=C1Nc2ccccc2C12CCCNC2>>CCC(C)N1CCCC2(C1)C(=O)Nc1ccccc12",
        "output": "187"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.CCc1ccc(C(F)(F)F)cc1.II.O=S(=O)(O)O.O=S([O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[O-][I+3]([O-])([O-])[O-]>>CCc1ccc(C(F)(F)F)cc1I",
        "output": "372"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)c1ccncc1.ClC(Cl)Cl.O.O=C(Cl)c1ccccc1.O=Cc1ccc(CCO)cc1>>O=Cc1ccc(CCOC(=O)c2ccccc2)cc1",
        "output": "51"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=Cc1ccc(-n2nnnc2-c2cccnc2NC(C)(C)C)c(F)c1F.CCOC(C)=O.[H][H].[Pd]>>CCc1ccc(-n2nnnc2-c2cccnc2NC(C)(C)C)c(F)c1F",
        "output": "555"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "N.O=[N+]([O-])c1ccccc1Cl.[Na+].[O-]c1ccccc1>>O=[N+]([O-])c1ccccc1Oc1ccccc1",
        "output": "299"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cccc(NC(=O)Nc2ccc(-c3c(Br)oc4ncnc(NC(=O)OC(C)(C)C)c34)cc2)c1.ClCCl.O=C(O)C(F)(F)F>>Cc1cccc(NC(=O)Nc2ccc(-c3c(Br)oc4ncnc(N)c34)cc2)c1",
        "output": "885"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOc1ccccc1C#N.NO>>CCOc1ccccc1C(N)=NO",
        "output": "400"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCC(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.F[P-](F)(F)(F)(F)F.NCCNC(=O)C/C=C/c1cccnc1>>CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCC(=O)NCCNC(=O)C/C=C/c1cccnc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCN1CCOCC1.C1CCOC1.CCN(CC)CC.COC(=O)COc1ccc(OC/C=C(/c2ccc(Cl)cc2)c2ccc(I)cc2)cc1C.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1.c1ccccc1>>COC(=O)COc1ccc(OC/C=C(/c2ccc(Cl)cc2)c2ccc(C#CCN3CCOCC3)cc2)cc1C",
        "output": "664"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Nc1cc(Cl)c(C(F)(F)F)cc1[N+](=O)[O-].O.[K]>>CCOc1cc(N)c([N+](=O)[O-])cc1C(F)(F)F",
        "output": "57"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ncccc1Oc1ccnc(NC(=O)OC(C)(C)C)c1.ClCCl.O=C(O)C(F)(F)F>>Cc1ncccc1Oc1ccnc(N)c1",
        "output": "885"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc(N(C)C=C2SC(=S)N(Cc3ccccc3)C2=O)cc1.ClCCl>>CN(C=C1SC(=S)N(Cc2ccccc2)C1=O)c1ccc(O)cc1",
        "output": "402"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1ccc(C(=O)NCc2ccc(-c3ncnc4[nH]c(C(=O)O)cc34)cc2F)cc1.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN(C)CCN>>CN(C)CCNC(=O)c1cc2c(-c3ccc(CNC(=O)c4ccc(C(C)(C)C)cc4)c(F)c3)ncnc2[nH]1",
        "output": "137"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CCC[C@H]1COc1cncc(CCCCCCO)c1.ClCCl.II.c1c[nH]cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN1CCC[C@H]1COc1cncc(CCCCCCI)c1",
        "output": "670"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)O.CCN(C(C)C)C(C)C.COc1cccc(Sc2ccn3nc([C@H](C)N)n(-c4ccccc4)c(=O)c23)c1.N#Cc1c(N)ncnc1Cl>>COc1cccc(Sc2ccn3nc([C@H](C)Nc4ncnc(N)c4C#N)n(-c4ccccc4)c(=O)c23)c1",
        "output": "110"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN.CCN=C=NCCCN(C)C.Cl.ClCCl.O=C(O)Cc1cc2c3c(c1)C(c1ccccc1)CCN3CCC2c1ccccc1.On1nnc2ccccc21>>CCNC(=O)Cc1cc2c3c(c1)C(c1ccccc1)CCN3CCC2c1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NCCN.CCOC(C)=O.CN(C)C=O.COc1ccc(-c2cc(=O)[nH]c(=S)n2CC(=O)O)c(OC)c1.c1ccncc1>>COc1ccc(-c2cc(=O)[nH]c(=S)n2CC(=O)NCCNC(=O)OC(C)(C)C)c(OC)c1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CC(=O)c1cccc(-n2cncn2)c1.CC(C)CN(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1C(F)(F)F>>CC(C)CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-n3cncn3)c2)cc1C(F)(F)F",
        "output": "929"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)C(C)(C)CCC(=O)N(C[C@@H]1CN(Cc2ccccc2)CCN1C(=O)OC(C)(C)C)C(C)C.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.O=C([O-])[O-].[Cl-].[K+].[K+].[Na+].[Na+]>>COC(=O)C(C)(C)CCC(=O)N(C[C@@H]1CN(Cc2ccccc2)CCN1)C(C)C",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC=CCc1c(O)ccc(Cl)c1Cl.CCCCCc1c(O)ccc(Cl)c1Cl.CCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.O=C(O)CCCCCBr.OC1Cc2c(ccc(Cl)c2Cl)O1.Oc1ccccc1.[Br-]>>CCCCCc1c(OCCCCCC(=O)O)ccc(Cl)c1Cl",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cl.N#Cc1cc([N+](=O)[O-])c(Cl)c([N+](=O)[O-])c1Cl.[Na+].[OH-]>>N#Cc1cc(N)c(Cl)c(N)c1Cl",
        "output": "204"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1cnc(Cl)nc1C(F)(F)F.C[O-].[Na+]>>COC(=O)c1cnc(OC)nc1C(F)(F)F",
        "output": "37"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1ccc(C(=O)O)c(F)c1C#N.COc1ccc(N)cc1.F[P-](F)(F)(F)(F)F.O.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>COc1ccc(NC(=O)c2ccc(OC)c(C#N)c2F)cc1",
        "output": "817"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNC1.Cc1ccccc1.O=C(CCl)Nc1ccc(Br)cc1>>O=C(CN1CCCC1)Nc1ccc(Br)cc1",
        "output": "340"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=c1c2cc(F)c(N3CCCC3)nc2n(C2CC2)c(=O)n1OCc1ccccc1.[H][H].[Pd]>>O=c1c2cc(F)c(N3CCCC3)nc2n(C2CC2)c(=O)n1O",
        "output": "630"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)O.CCN1CC2CCC(C1)c1cc(N)ccc12.CNC(=O)c1ccccc1Nc1nc(Cl)ncc1Cl.Cl>>CCN1CC2CCC(C1)c1cc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)ccc12",
        "output": "808"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCNCC1.O=C(O)c1cn(CCO)c2cc(Cl)c(F)cc2c1=O.c1ccncc1>>CN1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3CCO)CC1",
        "output": "280"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C(O)Cc1ccc(C(=O)O)o1>>COC(=O)Cc1ccc(C(=O)O)o1",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.COc1ccc(CS[C@H]2C[C@@H](C(=O)N3CC(N)C3)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1.ClCCl.O=C(Cl)OCc1ccc([N+](=O)[O-])cc1>>COc1ccc(CS[C@H]2C[C@@H](C(=O)N3CC(NC(=O)OCc4ccc([N+](=O)[O-])cc4)C3)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1",
        "output": "479"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.CCOC(=O)c1cc(OCc2ccccc2)c(F)cc1NC1CCOCC1.O.[K+].[OH-]>>O=C(O)c1cc(OCc2ccccc2)c(F)cc1NC1CCOCC1",
        "output": "5"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOC(C)=O.CN(C)C=O.Cc1noc(-c2ccc(Br)cc2)c1C(O)c1nnc(Cc2ccccc2)o1.c1c[nH]cn1>>Cc1noc(-c2ccc(Br)cc2)c1C(O[Si](C)(C)C(C)(C)C)c1nnc(Cc2ccccc2)o1",
        "output": "193"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.CN=C=O.Cl.Cl.Nc1ccc(-c2ccc(NC(=O)[C@H]3CN4CCC3CC4)cc2)cc1.O>>CNC(=O)Nc1ccc(-c2ccc(NC(=O)[C@H]3CN4CCC3CC4)cc2)cc1",
        "output": "176"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCn1cc(-c2cccc(-c3ccccc3)c2)nc1/C=C/c1ccc(Br)cc1.OB(O)c1ccc(O)cc1>>CCn1cc(-c2cccc(-c3ccccc3)c2)nc1/C=C/c1ccc(-c2ccc(O)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1ccc2ccc(O)cc2c1.CC(C)=O.CCI.O=C([O-])[O-].[K+].[K+]>>CCOc1ccc2ccc(NC(=O)OC(C)(C)C)cc2c1",
        "output": "198"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CO.O=C(O)c1ccc(CCc2ccccc2)cc1Nc1ccccc1[N+](=O)[O-].[C].[Pd]>>Nc1ccccc1Nc1cc(CCc2ccccc2)ccc1C(=O)O",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(CNc2nc(-c3nn(Cc4ccccc4F)c4ncccc34)ncc2[N+](=O)[O-])c(OC)c1.c1ccncc1>>COc1ccc(CNc2nc(-c3nn(Cc4ccccc4F)c4ncccc34)ncc2N)c(OC)c1",
        "output": "660"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.ClCCCl.O=Cc1ccccc1F.[Na+].c1ccc2ncc(Nc3ncnc4c3CNC4)cc2c1>>Fc1ccccc1CN1Cc2ncnc(Nc3cnc4ccccc4c3)c2C1",
        "output": "567"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCC.CCOC(C)=O.COC(=O)c1ccc2c(c1)OCC2(C)c1cc2c(cc1C)C(C)(C)CCC2(C)C.[Li+].[Na+].[OH-].[OH-]>>Cc1cc2c(cc1C1(C)COc3cc(C(=O)O)ccc31)C(C)(C)CCC2(C)C",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cc(O)ccc1-c1nc2ccc(C#N)cc2[nH]1.CS(=O)(=O)Cl>>COc1cc(OS(C)(=O)=O)ccc1-c1nc2ccc(C#N)cc2[nH]1",
        "output": "149"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Clc1ccnc2ccccc12.NCCO>>OCCNc1ccnc2ccccc12",
        "output": "78"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CS(=O)(=O)c1ccc(C(=O)N2CCOc3ccc(-c4ccc(N)c(N)c4)cc3C2)cc1.ClCCl.F[P-](F)(F)(F)(F)F>>CC(C)c1nc2ccc(-c3ccc4c(c3)CN(C(=O)c3ccc(S(C)(=O)=O)cc3)CCO4)cc2[nH]1",
        "output": "512"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.COc1ccc2c(c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O.O.O=C1CCC(=O)N1Br>>COc1ccc2c(c1)C(C)(C)c1[nH]c3cc(C#N)c(Br)cc3c1C2=O",
        "output": "4"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.Cl.Clc1ncnc(Cl)n1.N[C@@H]1CCN(c2ccc(F)cc2)C1.O.O=C([O-])[O-].[Na+].[Na+]>>Fc1ccc(N2CC[C@@H](Nc3ncnc(Cl)n3)C2)cc1",
        "output": "578"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(-c2cc(=O)c3c(OC)c(OC)c(OC)c(OC)c3o2)cc1OC.O=S(=O)(O)O.O=S(=O)(O)O.O=[N+]([O-])O>>COc1cc(-c2cc(=O)c3c(OC)c(OC)c(OC)c(OC)c3o2)c([N+](=O)[O-])cc1OC",
        "output": "21"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(=O)(=O)Cl.ClCCl.OC1CCCCCC1.c1ccncc1>>CS(=O)(=O)OC1CCCCCC1",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCCc1cccc(C(F)(F)F)c1>>COc1cc2nccc(Oc3ccc(NC(=O)OCCc4cccc(C(F)(F)F)c4)cc3)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Cc1c(COc2cc(O)c(C=O)cc2Br)cccc1-c1ccc2c(c1)OCCO2.N#Cc1cccc(CBr)c1.O.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1c(COc2cc(OCc3cccc(C#N)c3)c(C=O)cc2Br)cccc1-c1ccc2c(c1)OCCO2",
        "output": "127"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)c1cc(Cl)ncc1C(=O)NCC1CCOCC1.CO.CS(=O)(=O)O.Nc1ccc(F)c(F)c1>>CC(C)c1cc(Nc2ccc(F)c(F)c2)ncc1C(=O)NCC1CCOCC1",
        "output": "434"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "B.O=C(O)CCc1ccc(OC(F)F)c(F)c1>>OCCCc1ccc(OC(F)F)c(F)c1",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)c1ccc(OCc2ccccc2)cc1OCc1ccccc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.[Br-].[Br-].[Br-]>>O=C(CBr)c1ccc(OCc2ccccc2)cc1OCc1ccccc1",
        "output": "360"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Nc1cc(Cl)ccc1OCC1CO1.CC(C)O.CCO.O=c1[nH]c2cc(F)ccc2n1C1CCNCC1>>CC(=O)Nc1cc(Cl)ccc1OCC(O)CN1CCC(n2c(=O)[nH]c3cc(F)ccc32)CC1",
        "output": "76"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CC(C)(O)c1ccc(Br)cc1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.O.[K+]>>CC(C)(O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1",
        "output": "942"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCC(=O)Cl.Cc1c(N[C@@H](c2nnc(-c3ccc(N)cc3)o2)[C@@H](C)O[Si](C)(C)C(C)(C)C)ccc(C#N)c1Cl.ClCCl.c1ccncc1>>CCCC(=O)Nc1ccc(-c2nnc([C@H](Nc3ccc(C#N)c(Cl)c3C)[C@@H](C)O[Si](C)(C)C(C)(C)C)o2)cc1",
        "output": "9"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOCC.Cl.O.[N-]=[N+]=NCc1ccc(-c2nn(Cc3ccccc3)c3ccccc23)o1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NCc1ccc(-c2nn(Cc3ccccc3)c3ccccc23)o1",
        "output": "89"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(CSc1ccc(Cl)cc1)C(=O)CBr.Cc1ccccc1.O=C([O-])[O-].Oc1ccc(Cl)cc1.[K+].[K+]>>CC(C)(CSc1ccc(Cl)cc1)C(=O)COc1ccc(Cl)cc1",
        "output": "221"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.ClC(Cl)Cl.NCc1ccc(CO)o1.O=[N+]([O-])c1cnccc1Cl>>O=[N+]([O-])c1cnccc1NCc1ccc(CO)o1",
        "output": "78"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc(F)c(Br)cc1F.COc1ccc(Br)cc1C.c1ccc(CC2CCNCC2)cc1.c1ccc(CCN2CCNCC2)cc1>>COc1cc(F)c(N2CCC(Cc3ccccc3)CC2)cc1F",
        "output": "294"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(O)c1ccc(NS(=O)(=O)c2cc(-c3cccc(F)c3)c(Cl)s2)cc1O.OCCO>>O=C(OCCO)c1ccc(NS(=O)(=O)c2cc(-c3cccc(F)c3)c(Cl)s2)cc1O",
        "output": "33"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.COCCBr.O=C([O-])[O-].Oc1cc(Cl)cc(Br)c1.[Cs+].[Cs+]>>COCCOc1cc(Cl)cc(Br)c1",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)O.Cc1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)c(C(=O)N2C3CCC2C(COc2ccccn2)C3)n1.Cl>>Cc1ccc(N2CCNCC2)c(C(=O)N2C3CCC2C(COc2ccccn2)C3)n1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COc1ccc(S(=O)(=O)Cl)c2ccccc12.C[Si](C)(C)[N-][Si](C)(C)C.O=C(O)c1c[nH]c2ccccc12.O=C([O-])O.[Na+].[Na+]>>COc1ccc(S(=O)(=O)n2cc(C(=O)O)c3ccccc32)c2ccccc12",
        "output": "648"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCN.Cc1ccc(S(=O)(=O)OCC2COc3c(F)cc(S(C)(=O)=O)cc3O2)cc1>>CCNCC1COc2c(F)cc(S(C)(=O)=O)cc2O1",
        "output": "853"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.COc1ccc(C(=O)O)c(F)c1.Cc1ccc2nc(-c3ccc(N)cc3)cn2c1.O=S(Cl)Cl.c1ccncc1>>COc1ccc(C(=O)Nc2ccc(-c3cn4cc(C)ccc4n3)cc2)c(F)c1",
        "output": "50"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=C(CCCCl)c1ccccc1.OCCO>>ClCCCC1(c2ccccc2)OCCO1",
        "output": "93"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCC.CCN(C(C)C)C(C)C.CCOC(C)=O.CCOP(=O)(Cc1ccc(N)cc1)OCC.CS(=O)c1cccc(CN)c1.CS(=O)c1cccc(CNc2nc(Cl)ncc2C(F)(F)F)c1.CS(=O)c1cccc(CNc2ncc(C(F)(F)F)c(Cl)n2)c1.Cl.FC(F)(F)c1cnc(Cl)nc1Cl.O=C(O)C(F)(F)F>>CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(NCc3cccc(S(C)=O)c3)n2)cc1)OCC",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.CC(=O)O.Cc1ccc(F)c2c1CCCO2.Cc1ccccc1>>Cc1c(Br)cc(F)c2c1CCCO2",
        "output": "98"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cl.N#Cc1cccc(F)c1.O=C([O-])[O-].Oc1ccc(OC(F)(F)F)cc1.[Cs+].[Cs+]>>N#Cc1cccc(Oc2ccc(OC(F)(F)F)cc2)c1",
        "output": "564"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.O=c1c(OCc2ccccc2)c(-c2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)oc2cc(OCc3ccccc3)c(I)c(O)c12>>O=c1c(OCc2ccccc2)c(-c2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)oc2cc(OCc3ccccc3)c(I)c(OCc3ccccc3)c12",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)c1ccc(CC(=O)NC(CC(C)C)c2ccccc2N2CCCCC2)cc1OCC.Cl.[Na+].[OH-]>>CCOc1cc(CC(=O)NC(CC(C)C)c2ccccc2N2CCCCC2)ccc1C(=O)O",
        "output": "5"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1c(O)c2cc(F)ccc2n(Cc2ccccc2)c1=O.Cc1ccccc1.NC1CCCCC1.O>>O=C(NC1CCCCC1)c1c(O)c2cc(F)ccc2n(Cc2ccccc2)c1=O",
        "output": "498"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1=COCCC1.CC(O)C1CCN(C(=O)OC(C)(C)C)C1=O.Cc1ccc(S(=O)(=O)O)cc1.ClCCl>>CC(OC1CCCCO1)C1CCN(C(=O)OC(C)(C)C)C1=O",
        "output": "306"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCNC(=O)CCCNC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2c(c1)c1c(n2CCF)CCC(C2CCOCC2)C1>>CCNC(=O)CCCN(C)C(=O)c1ccc2c(c1)c1c(n2CCF)CCC(C2CCOCC2)C1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CCOC(=O)CCc1ccc(Oc2cc(F)cc(OC)c2)cc1C.ClCCl>>CCOC(=O)CCc1ccc(Oc2cc(O)cc(F)c2)cc1C",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=C1Nc2cc([N+](=O)[O-])ccc2OC1(F)F.[Pd]>>Nc1ccc2c(c1)NC(=O)C(F)(F)O2",
        "output": "202"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cccc(S(=O)(=O)Cl)c1.NC1CCN(CCc2c[nH]c3ccccc23)CC1.O>>COc1cccc(S(=O)(=O)NC2CCN(CCc3c[nH]c4ccccc34)CC2)c1",
        "output": "43"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.O.O=C([O-])[O-].O=Cc1c(Cl)cc(O)cc1Cl.[K+].[K+]>>COc1cc(Cl)c(C=O)c(Cl)c1",
        "output": "62"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(C(=O)Cl)cc1.OC[C@@H]1CC[C@H](n2cnc3c(NCC4CC4)ncnc32)O1>>Cc1ccc(C(=O)OC[C@@H]2CC[C@H](n3cnc4c(NCC5CC5)ncnc43)O2)cc1",
        "output": "51"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(CCl)N(C)C.COc1cc(-c2nc3ccc(O)cc3n2Cc2ccccc2C(F)(F)F)cc(OC)c1OC>>COc1cc(-c2nc3ccc(OCC(C)N(C)C)cc3n2Cc2ccccc2C(F)(F)F)cc(OC)c1OC",
        "output": "74"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1nnn(-c2cccc(Cl)c2)n1.O.[Li+].[OH-]>>O=C(O)c1nnn(-c2cccc(Cl)c2)n1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.Fc1cnc(Cl)nc1.NCC1CCN(C(=O)OCc2ccc(F)cc2)CC1>>O=C(OCc1ccc(F)cc1)N1CCC(CNc2ncc(F)cn2)CC1",
        "output": "544"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCO.Cc1nccc(Cl)n1.O=C(C1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1)N1CCNCC1>>Cc1nccc(N2CCN(C(=O)C3CCN(S(=O)(=O)c4ccc(Br)cc4)CC3)CC2)n1",
        "output": "162"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.Cl.NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCNCC1.O=C(O)/C=C/c1cccc(F)c1>>NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cccc(F)c2)CC1",
        "output": "811"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cc(C(=O)OCC)n(CC(=O)Nc2ccc(Cl)cn2)n1.Cl.O.[Na+].[OH-]>>CCOC(=O)c1cc(C(=O)O)n(CC(=O)Nc2ccc(Cl)cn2)n1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(=O)Cl.CCN(CC)CC.CCOCC.Cl.Cl.Cl.ClC(Cl)Cl.c1ccc([C@@H]2CN3CCNC[C@H]3c3ccccc32)cc1>>CCC(=O)N1CCN2C[C@@H](c3ccccc3)c3ccccc3[C@@H]2C1",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc2cc(-c3ccc(-c4ccccc4)n3Cc3ccccc3)ccc2c1.Cl.c1ccncc1>>Oc1ccc2cc(-c3ccc(-c4ccccc4)n3Cc3ccccc3)ccc2c1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)NCCN.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.O=C(O)c1ccc(-c2ncc(Br)c(Nc3cc(C4CC4)[nH]n3)n2)s1.On1nnc2ccccc21>>CC(=O)NCCNC(=O)c1ccc(-c2ncc(Br)c(Nc3cc(C4CC4)[nH]n3)n2)s1",
        "output": "736"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cccc(Sc2cnc(Nc3nc(C4CCN(C(=O)OC(C)(C)C)CC4)cs3)c(Oc3ccc(F)cc3Br)c2)c1.ClCCl.O.O=C(O)C(F)(F)F.O=C([O-])[O-].[Na+].[Na+]>>COc1cccc(Sc2cnc(Nc3nc(C4CCNCC4)cs3)c(Oc3ccc(F)cc3Br)c2)c1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C1CCC(N)CC1.CS(=O)(=O)CCOc1cccc2c1nnn2-c1ccnc(S(C)(=O)=O)n1>>CCOC(=O)C1CCC(Nc2nccc(-n3nnc4c(OCCS(C)(=O)=O)cccc43)n2)CC1",
        "output": "629"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1cc2c(cc1F)N(C1CCN(C(=O)OCc3ccccc3)CC1)C(=O)C2.Cl.[Na+].[OH-]>>O=C(O)c1cc2c(cc1F)N(C1CCN(C(=O)OCc3ccccc3)CC1)C(=O)C2",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#Cc1cc(OCc2ccccc2)c(OCc2ccccc2)nn1.C1=NCCCN(C2CCCCCCCCCC2)CCCCC1.C1CCOC1.Cc1cc(Br)ccc1C(F)(F)F.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>Cc1cc(C#Cc2cc(OCc3ccccc3)c(OCc3ccccc3)nn2)ccc1C(F)(F)F",
        "output": "659"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CCCCl.O=S(=O)(c1ccc(O)cc1)c1oc2ccccc2c1-c1ccccc1>>CCN(CC)CCCOc1ccc(S(=O)(=O)c2oc3ccccc3c2-c2ccccc2)cc1",
        "output": "74"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.COc1ccc(-c2nc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)ccc2Cl)cn1.Cl>>O=C(Nc1ccc(Cl)c(-c2ccc(=O)[nH]c2)n1)C1(c2ccc3c(c2)OC(F)(F)O3)CC1",
        "output": "758"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#Cc1ccc(N)nc1N.C1CCOC1.CCN(CC)CC.O.ON=C(Cl)Cc1ccc(Oc2ccccc2F)nc1>>Nc1ccc(-c2cc(Cc3ccc(Oc4ccccc4F)nc3)no2)c(N)n1",
        "output": "976"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(CO)C1CCCCC1.CCN(CC)CC.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)(C=O)C1CCCCC1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1CCOCC1.C[C@H](N)CNc1ccc(OC(F)(F)F)cc1.ClCCCl.ClCCl.O=C(O)[C@H](CS(=O)(=O)Cc1ccccc1)NC(=O)N1CCOCC1.On1nnc2ccccc21>>C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)[C@H](CS(=O)(=O)Cc1ccccc1)NC(=O)N1CCOCC1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CC2CNCC(C1)O2.CC(C)(C)[O-].Cc1ccccc1.Clc1cc(Br)cnc1Cl.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)OC(=O)N1CC2CN(c3cnc(Cl)c(Cl)c3)CC(C1)O2",
        "output": "597"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)C1(C)CCN(C2=NOC3(C2)CN(Cc2cc(OCC4(F)CC4)c(-c4ccc(F)cc4)c(C4CC4)c2)C3)CC1.[Na+].[OH-]>>CC1(C(=O)O)CCN(C2=NOC3(C2)CN(Cc2cc(OCC4(F)CC4)c(-c4ccc(F)cc4)c(C4CC4)c2)C3)CC1",
        "output": "281"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.NC(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1cccc(F)n1.O.O.O=C(O)c1ccc(F)c2ccccc12.On1nnc2ccccc21>>O=C(NC(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1cccc(F)n1)c1ccc(F)c2ccccc12",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.Clc1ccc2c(c1)CCC21CCNC1>>CC(C)(C)OC(=O)N1CCC2(CCc3cc(Cl)ccc32)C1",
        "output": "694"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1n[nH]c(N)c1-c1nc2ccc(CBr)cc2s1.NCCO>>Cc1n[nH]c(N)c1-c1nc2ccc(CNCCO)cc2s1",
        "output": "446"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cl.N#Cc1cccc(F)c1.O=C([O-])[O-].Oc1ccc2c(c1)CCC2.[Cs+].[Cs+]>>N#Cc1cccc(Oc2ccc3c(c2)CCC3)c1",
        "output": "564"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1=C(c2ccc3c(c2)C(C)(C)CCC3(C)C)CCCC1.CCOCC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC1(C)CCC(C)(C)c2cc(C3=C(CO)CCCC3)ccc21",
        "output": "150"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCO.COc1ccc2nc(-c3ccc(C)c([N+](=O)[O-])c3)cn2n1.O.[Fe]>>COc1ccc2nc(-c3ccc(C)c(N)c3)cn2n1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)O)CC2)nc1CN1CCCCC1=O.NS(=O)(=O)Cc1ccc(C(F)(F)F)cc1>>CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccc(C(F)(F)F)cc3)CC2)nc1CN1CCCCC1=O",
        "output": "644"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.Oc1ccc(Cl)cc1F.[Na+].[Na+]>>O=[N+]([O-])c1ccc(Oc2ccc(Cl)cc2F)cc1",
        "output": "564"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(C)=O.C[Mg]Br.O=C1CCC[C@H](Nc2nc(Cl)ncc2F)C1.[Cl-].[NH4+]>>CC1(O)CCC[C@H](Nc2nc(Cl)ncc2F)C1",
        "output": "514"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCC(NCc1ccc(NC(=O)c2cc(N(CC3CC3)C3CCCCC3)ncn2)cc1)C(=O)OC.CO.Cl.[Na+].[OH-]>>CCC(NCc1ccc(NC(=O)c2cc(N(CC3CC3)C3CCCCC3)ncn2)cc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cn2ncnc(N)c2c1-c1ccc([N+](=O)[O-])cc1.Cl.[Na+].[OH-]>>Nc1ncnn2cc(C(=O)O)c(-c3ccc([N+](=O)[O-])cc3)c12",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCN1CCNCC1.Cl.Oc1ccc(CCl)c2cccnc12>>C#CCN1CCN(Cc2ccc(O)c3ncccc23)CC1",
        "output": "156"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.COC(=O)[C@H]1CNCC[C@@H]1C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)C1(c2ccc(Cl)cc2)CCC1>>COC(=O)[C@H]1CN(C(=O)C2(c3ccc(Cl)cc3)CCC2)CC[C@@H]1C",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc2ncc(F)c(C(C)C(O)C34CCC(NC(=O)OC(C)(C)C)(CC3)CO4)c2n1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc2ncc(F)c(C(C)C(O)C34CCC(N)(CC3)CO4)c2n1",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.Cc1ccccc1.Nc1cccc(F)c1.O=C(O)c1c(Cl)cccc1[N+](=O)[O-].O=C([O-])O.O=S(Cl)Cl.[Na+]>>O=C(Nc1cccc(F)c1)c1c(Cl)cccc1[N+](=O)[O-]",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.ClCCl.OCc1cc2cc(Cl)ccc2[nH]1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCc1cc2cc(Cl)ccc2[nH]1",
        "output": "193"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=Cc1ccc(C)nc1.CS(C)=O.Cc1ccc2[nH]c3c(c2c1)C1CCC(C3)N1.O.Oc1ccc(O)cc1.[Na]>>Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CC2CCC1N2",
        "output": "986"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCl.O=C(O)CCBr.c1ccc(-c2cc3c(cn2)CCCN3c2ccnc(NC3CCNCC3)n2)cc1>>O=C(CCBr)N1CCC(Nc2nccc(N3CCCc4cnc(-c5ccccc5)cc43)n2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCOC(=O)C1(CCCc2c(F)cnc3ccc(OC)cc23)CCNCC1.Fc1cc(OCCBr)cc(F)c1F.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CCOC(=O)C1(CCCc2c(F)cnc3ccc(OC)cc23)CCN(CCOc2cc(F)c(F)c(F)c2)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.C[C@H]1C[C@@]2(C=CS(=O)(=O)N2c2cccc(F)c2)CCN1C(=O)OCc1ccccc1.Cl.ClCCl.[Na+].[OH-]>>C[C@H]1C[C@@]2(C=CS(=O)(=O)N2c2cccc(F)c2)CCN1",
        "output": "428"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-c2ccnc3[nH]ccc23)cc1.[K+].[OH-]>>O=C(O)c1ccc(-c2ccnc3[nH]ccc23)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.NN.O.O=C1c2ccccc2C(=O)N1Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1>>NCc1cc2nc(Cl)nc(N3CCOCC3)c2s1",
        "output": "242"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)c1cn(C)c2ccc(Br)cc12.Cl.O.[Na+].[OH-]>>Cn1cc(C(=O)O)c2cc(Br)ccc21",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1CCCC1=O.Clc1ncc(Br)cn1.O.O=C([O-])[O-].[K+].[K+].c1ccc(-c2c[nH]cn2)cc1>>Brc1cnc(-n2cnc(-c3ccccc3)c2)nc1",
        "output": "788"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1nc2c(c(-c3ccc(F)cc3)c1CO)CN(C(=O)OCC[Si](C)(C)C)CC2(C)C.CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-]>>CC(C)c1nc2c(c(-c3ccc(F)cc3)c1C=O)CN(C(=O)OCC[Si](C)(C)C)CC2(C)C",
        "output": "520"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)NC(=O)n1nc(NCC(=O)NC2CNC2)c2cc(C(F)(F)F)ccc21.COc1ccc(C2CCC(=O)CC2)cn1>>COc1ccc(C2CCC(N3CC(NC(=O)CNc4nn(C(=O)NC(C)C)c5ccc(C(F)(F)F)cc45)C3)CC2)cn1",
        "output": "187"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.ClCCl.Cn1cnc(S(=O)(=O)N2C[C@H](N)[C@@H](c3ccc(F)cc3)C2)c1.O.O=C(O)Cc1ccccc1Br.[Cl-].[Na+]>>Cn1cnc(S(=O)(=O)N2C[C@H](NC(=O)Cc3ccccc3Br)[C@@H](c3ccc(F)cc3)C2)c1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.O=C(NCC(=O)N1CCC[C@H]1C(=O)O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCN(C(=O)[C@@H]2CCCN2C(=O)CNC(=O)c2ccc(S(=O)(=O)Nc3ccccc3Oc3ccccc3)cc2)CC1",
        "output": "685"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)N1CCc2c1ccc([N+](=O)[O-])c2F.Cl>>O=[N+]([O-])c1ccc2c(c1F)CCN2",
        "output": "504"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(=O)(=O)c1cccc(N)c1.O=C(O)c1cnn2c(C3CC3)cc(-c3ccc(Cl)cc3)nc12>>CS(=O)(=O)c1cccc(NC(=O)c2cnn3c(C4CC4)cc(-c4ccc(Cl)cc4)nc23)c1",
        "output": "969"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cc(=O)[nH]nc1-c1ccccc1.O=P(Cl)(Cl)Cl>>Cc1cc(Cl)nnc1-c1ccccc1",
        "output": "537"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccc(-c2ccc(Br)c(C)c2)o1.O=C(O)c1ccc(B(O)O)cc1>>Cc1ccc(-c2ccc(-c3ccc(C(=O)O)cc3)c(C)c2)o1",
        "output": "837"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)Cc1ccc(-c2ccccc2NC(=O)c2cncc(Br)c2)s1.COCCOC.COc1ccc(B(O)O)c(OC)c1.N#N.O=C([O-])O.[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)Cc1ccc(-c2ccccc2NC(=O)c2cncc(-c3ccc(OC)cc3OC)c2)s1",
        "output": "833"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)[C@@H](O)C[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)O.CC(C)(C)[Si](C)(C)Cl.CCCCCC.CCOC(C)=O.CN(C)C=O.CO.O.O=C([O-])[O-].[K+].[K+].c1c[nH]cn1>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)[C@H](C[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)O)O[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CCc1ccc(O)c(Br)c1.OC1CCCCC1>>CCOC(=O)CCc1ccc(OC2CCCCC2)c(Br)c1",
        "output": "846"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC1CCc2c(O)c3c(c(O)c2C1)C(=O)c1cccc(O)c1C3=O.CO.Cl>>O=C1c2cccc(O)c2C(=O)c2c(O)c3c(c(O)c21)CC(O)CC3",
        "output": "325"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.Cl[Pd]Cl.O.O=C([O-])[O-].O=S1(=O)c2ccc(Cl)nc2N[C@H]2CCN1C2.OB(O)c1cccc(C(F)(F)F)c1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=S1(=O)c2ccc(-c3cccc(C(F)(F)F)c3)nc2N[C@H]2CCN1C2",
        "output": "865"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.Cc1ccccc1.FC(F)(F)c1ccc(OCC2CO2)cc1.Oc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl>>OC(COc1ccc(C(F)(F)F)cc1)COc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl",
        "output": "277"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCC(=O)Cl.COc1ccc(N)c([N+](=O)[O-])c1.O.c1ccncc1>>CCCCC(=O)Nc1ccc(OC)cc1[N+](=O)[O-]",
        "output": "134"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCC.CCOC(C)=O.O=C(O)CCc1ccc(C(F)(F)F)c(F)c1.O=S(=O)(O)Cl>>O=C1CCc2ccc(C(F)(F)F)c(F)c21",
        "output": "274"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)C(C)(C)c1ccc(Cl)c(F)c1.O.[K+].[OH-]>>CC(C)(C(=O)O)c1ccc(Cl)c(F)c1",
        "output": "203"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COCC1(C(C)=O)CCN(C(=O)OC(C)(C)C)CC1.ClCCl.N[C@@H]1C[C@H]1c1ccccc1.[Na+]>>COCC1(C(C)N[C@@H]2C[C@H]2c2ccccc2)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "236"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CCCl.CN(C)C=O.Cl.O=C([O-])[O-].Oc1cccc2c1c1cccc(F)c1n2Cc1ccccc1.[I-].[K+].[K+].[Na+]>>CCN(CC)CCOc1cccc2c1c1cccc(F)c1n2Cc1ccccc1",
        "output": "74"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.O=C(NC1CCN(c2ncnc3c2c(Br)cn3S(=O)(=O)c2ccccc2)CC1)c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+]>>O=C(NC1CCN(c2ncnc3[nH]cc(Br)c23)CC1)c1ccccc1",
        "output": "831"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCC.N#CC1(NCc2ccccc2)CCCC1.O.[Al+3].[H-].[H-].[H-].[H-].[K+].[Li+].[OH-]>>NCC1(NCc2ccccc2)CCCC1",
        "output": "246"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.Cc1cccc(C=O)c1.NNc1cc(N2CCOCC2)c2nc(-c3ccncc3)cn2n1>>Cc1cccc(C=NNc2cc(N3CCOCC3)c3nc(-c4ccncc4)cn3n2)c1",
        "output": "167"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCCCSc1ccccc1.O=C(Nc1cccc(C2CCNCC2)c1)C1CC1>>O=C(Nc1cccc(C2CCN(CCCCSc3ccccc3)CC2)c1)C1CC1",
        "output": "138"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC=[N+]=[N-].CCCCCCCSC1CCC(=O)C1CCCCCCC(=O)O.CCO.CCOCC.Cl>>CCCCCCCSC1CCC(=O)C1CCCCCCC(=O)OCC",
        "output": "47"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.ClCCl.N#C[C@]1(c2ccccn2)C[C@@H]1CO.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OC[C@H]1C[C@]1(C#N)c1ccccn1",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN[C@@H](Cc1c[nH]cn1)C(=O)O.CO>>CN[C@@H](Cc1c[nH]cn1)C(=O)OC",
        "output": "195"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)Oc1cc(C(F)(F)F)c2cc3c(cc2n1)OCC(CO)N3CC(F)(F)F.CI.[H-].[Na+]>>COCC1COc2cc3nc(OC(C)C)cc(C(F)(F)F)c3cc2N1CC(F)(F)F",
        "output": "140"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CC(N2CCNCC2)C1.Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)O)cn2)c1O>>Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)N3CCN(C4CCC4)CC3)cn2)c1O",
        "output": "256"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNCCN1.COC[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1ccc(Cl)nc1)C2>>COC[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1ccc(N3CCNCC3)nc1)C2",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O.O=C1c2ccccc2C(=O)c2cc([N+](=O)[O-])ccc21.[C].[Pd]>>Nc1ccc2c(c1)C(=O)c1ccccc1C2=O",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCC.CCCI.CCOC(C)=O.CN(C)C=O.Cc1cc(O)c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n1Cc1ccccc1.O.[H-].[Na+]>>CCCOc1cc(C)n(Cc2ccccc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "198"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1c([C@@H](O)CN2CCC(N)CC2)ccc2c1COC2=O.Cl.O=C(O)c1ccc(-n2cncn2)cc1>>Cc1c([C@@H](O)CN2CCC(NC(=O)c3ccc(-n4cncn4)cc3)CC2)ccc2c1COC2=O",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C#N)c1ccccn1.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(CN)c1ccccn1",
        "output": "246"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.COc1ccc(C(=O)Cl)cc1.ClCCl.NCCNc1nc(Cl)nc2c1ncn2C1CCCC1.O>>COc1ccc(C(=O)NCCNc2nc(Cl)nc3c2ncn3C2CCCC2)cc1",
        "output": "271"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.CC(=O)c1ccc(-c2ccc(N)cc2)o1>>CC(=O)Nc1ccc(-c2ccc(C(C)=O)o2)cc1",
        "output": "6"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCC/C=C\\CCCC(CCC/C=C\\CCCCC)C(CCC/C=C\\CCCCC)OC(=O)CCCCCBr.CCO.CNC>>CCCCC/C=C\\CCCC(CCC/C=C\\CCCCC)C(CCC/C=C\\CCCCC)OC(=O)CCCCCN(C)C",
        "output": "73"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=C(Cl)CC1(C(=O)O)CCCC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(Cc1ccco1)C(=O)[C@@H](N)Cc1ccc(-c2ccccc2)cc1.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)C(F)(F)F>>C=C(Cl)CC1(C(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N(C)Cc2ccco2)CCCC1",
        "output": "133"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1cccc(Br)c1>>CC(C)(C)OC(=O)NCc1cccc(Br)c1",
        "output": "686"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCCCC(CO)(CCCC)COC>>CCCCC(CCCC)(COC)CO[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)c1cc(O)no1.[Na+].[OH-]>>O=C(O)c1cc(O)no1",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrBr.ClC(Cl)Cl.Nc1cccc(Cl)n1>>Nc1nc(Cl)ccc1Br",
        "output": "292"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCBr.CCOCC.COC(OC)c1c[nH]c(-c2ccccc2)n1.CS(C)=O.[K+].[OH-]>>CCCCn1cc(C(OC)OC)nc1-c1ccccc1",
        "output": "276"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.Clc1ccnc(Cl)n1.O=C(O)C(F)(F)F.O=S(=O)(c1ccccc1Cl)[C@H]1CCNC1.[F-].[K+]>>O=S(=O)(c1ccccc1Cl)[C@H]1CCN(c2ccnc(Cl)n2)C1",
        "output": "162"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)/C=C/c1cnc2cc(CCc3nc(C(C)C)cs3)ccn2c1=O.CO.O.[Li+].[OH-]>>CC(C)c1csc(CCc2ccn3c(=O)c(/C=C/C(=O)O)cnc3c2)n1",
        "output": "122"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)O.COC(=O)c1cccc2cc(N)ccc12.COc1cc2ncnc(Cl)c2cc1OC.O.O=C(O)C(F)(F)F.[Na+].[OH-]>>COC(=O)c1cccc2cc(Nc3ncnc4cc(OC)c(OC)cc34)ccc12",
        "output": "352"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.CN(C)CCCO.O=S(=O)(c1ccc(/C=C/c2ccc(F)cc2F)nc1)c1ccccc1F.[H-].[Na+]>>CN(C)CCCOc1ccccc1S(=O)(=O)c1ccc(/C=C/c2ccc(F)cc2F)nc1",
        "output": "485"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1c(N)cc(Cl)cc1Cl.COc1ccc(S(=O)(=O)Cl)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1.ClCCCl.c1ccncc1>>COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2OC)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1",
        "output": "68"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.COc1cc(Nc2nc3cccc(-c4ccc(CN)cc4)c3o2)cc(OC)c1OC.c1ccncc1>>COc1cc(Nc2nc3cccc(-c4ccc(CNC(C)=O)cc4)c3o2)cc(OC)c1OC",
        "output": "206"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1cc2c(cc1C)-c1nc(-c3ncnn3C(C)C)cn1CCO2.COC(OC)N(C)C>>Cc1cc2c(cc1C(=O)/C=C/N(C)C)OCCn1cc(-c3ncnn3C(C)C)nc1-2",
        "output": "898"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1ccc2[nH]ccc2c1.CC(C)CI.CCOC(C)=O.CN(C)C=O.O.[H-].[Na+]>>CC(C)Cn1ccc2cc(Br)ccc21",
        "output": "302"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CN(C)C=O.CN(C)CCN(C)C.Fc1cc(-c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2)ccc1Br.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[C-]#N.[C-]#N.[Pd].[Pd].[Zn+2]>>N#Cc1ccc(-c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2)cc1F",
        "output": "65"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[O-].CS(C)=O.NC(=O)Cc1cc(Cl)ccn1.Nc1cc(F)c(O)cc1F.[K+].[Na+].[OH-]>>NC(=O)Cc1cc(Oc2cc(F)c(N)cc2F)ccn1",
        "output": "351"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)Cc1cc(=O)[nH][nH]1.CO.O.[Na+].[OH-]>>O=C(O)Cc1cc(=O)[nH][nH]1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#C[Si](C)(C)C.C1COCCO1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)NC(C)C.CCOC(C)=O.C[Si](C)(C)c1ccc(Br)cc1.Cl[Pd]Cl.N#Cc1ccccc1.N#Cc1ccccc1.[Cu]I>>C[Si](C)(C)C#Cc1ccc([Si](C)(C)C)cc1",
        "output": "671"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.CNC(=O)c1cc(Cl)ccn1.Cc1cc(C#N)ccc1O.O=C([O-])[O-].[K+].[K+]>>CNC(=O)c1cc(Oc2ccc(C#N)cc2C)ccn1",
        "output": "351"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C(OC(C)(C)C)OC(C)(C)C.Cc1ccccc1.O=C(O)c1ccccc1N1CN(c2ccccc2)C2(CCN(C(=O)OCc3ccccc3)CC2)C1=O>>CC(C)(C)OC(=O)c1ccccc1N1CN(c2ccccc2)C2(CCN(C(=O)OCc3ccccc3)CC2)C1=O",
        "output": "768"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)N.CCO.Clc1nc(Cl)c2ncn(C3CCCCO3)c2n1.O=C([O-])O.[Na+]>>CC(C)(C)Nc1nc(Cl)nc2c1ncn2C1CCCCO1",
        "output": "145"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "FC(F)(F)c1ccc(Cl)nc1.N>>Nc1ccc(C(F)(F)F)cn1",
        "output": "388"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CCCO.Cc1ccc(Cn2c(-c3ccc(Oc4ccc(N)cc4)cc3)cccc2=O)c(C)c1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCN(CC)CCCOC(=O)Nc1ccc(Oc2ccc(-c3cccc(=O)n3Cc3ccc(C)cc3C)cc2)cc1",
        "output": "960"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(C)=O.COc1ccc(Cn2ncc3c(N4CCC[C@H](NC(=O)OC(C)(C)C)C4)c(NC(=O)OC(C)(C)C)cnc32)cc1.Cl>>COc1ccc(Cn2ncc3c(N4CCC[C@H](NC(=O)OC(C)(C)C)C4)c(N)cnc32)cc1",
        "output": "877"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1nc(N)sc1C(=O)NCc1ccccc1.O=C(Cl)C1CC1>>Cc1nc(NC(=O)C2CC2)sc1C(=O)NCc1ccccc1",
        "output": "553"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)COc1ccc(F)c(NCc2cc(C)cc(-c3cccc(F)c3)c2F)c1F.O.O.[Li]O>>Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)c(F)c(-c2cccc(F)c2)c1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2nc3c(I)ccnc3[nH]2)cc1.Cl.O.[Li+].[OH-]>>O=C(O)c1ccc(-c2nc3c(I)ccnc3[nH]2)cc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(Cl)c(Br)c1.O[C@H]1CNC[C@@H]1O>>O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2C[C@H](O)[C@@H](O)C2)c(Br)c1",
        "output": "220"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)O.CN1C(=O)C(F)(F)CN(C2CCCC2)c2nc(Cl)ncc21.COc1cc(C(=O)O)ccc1N.Cl>>COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CI.CN(C)C=O.COC(=O)c1ccc(N(C)CC2(O)CCN(CCc3ccc(C#N)cc3)CC2)cc1.[H-].[Na+]>>COC(=O)c1ccc(N(C)CC2(OC)CCN(CCc3ccc(C#N)cc3)CC2)cc1",
        "output": "140"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCl.N#Cc1ccc(C(O)c2cccnc2)cc1F.O=[Mn]=O>>N#Cc1ccc(C(=O)c2cccnc2)cc1F",
        "output": "852"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC=C1Cc2cc(OCC(=O)O)c(Cl)c(Cl)c2C1=O.CO.O=S(=O)(O)O>>CC=C1Cc2cc(OCC(=O)OC)c(Cl)c(Cl)c2C1=O",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCn1c(=O)n(OCc2ccccc2)c(=O)c2cc(F)c(F)cc21.CO.[H][H].[Pd]>>CCn1c(=O)n(O)c(=O)c2cc(F)c(F)cc21",
        "output": "630"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CNCCN1CCN(c2nccnc2Cl)CC1.Cl.ClCCl.O=C([O-])O.O=S(=O)(Cl)c1cccnc1.[Na+]>>CN(CCN1CCN(c2nccnc2Cl)CC1)S(=O)(=O)c1cccnc1",
        "output": "169"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CSc1c(S(=O)(=O)NC(C)(C)C)ccn1C.ClCCl.O=C(O)C(F)(F)F>>CSc1c(S(N)(=O)=O)ccn1C",
        "output": "680"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)Br.O=C([O-])[O-].Oc1ccc(F)cc1Br.[Cs+].[Cs+]>>CC(C)Oc1ccc(F)cc1Br",
        "output": "153"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCc1ccccc1.O=C(NCc1cccc(F)c1)c1cccc2nc(-c3c(NC[C@@H](O)c4ccccc4)cc[nH]c3=O)[nH]c12.O=C(O)c1cccc2nc(-c3c(NC[C@@H](O)c4ccccc4)cc[nH]c3=O)[nH]c12>>O=C(NCc1ccccc1)c1cccc2nc(-c3c(NC[C@@H](O)c4ccccc4)cc[nH]c3=O)[nH]c12",
        "output": "790"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N(C)C.ClCCl.Nc1cc(C(F)(F)F)c(Br)cc1Cl.O=C(Cl)c1ccc(F)nc1>>O=C(Nc1cc(C(F)(F)F)c(Br)cc1Cl)c1ccc(F)nc1",
        "output": "642"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC[SiH](CC)CC.CN(C)CCN1Cc2cc(Cl)ccc2-c2c(C3CCCCC3)c3ccc(C(=O)OC(C)(C)C)cc3n2CC1=O.O.O=C(O)C(F)(F)F>>CN(C)CCN1Cc2cc(Cl)ccc2-c2c(C3CCCCC3)c3ccc(C(=O)O)cc3n2CC1=O",
        "output": "752"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCC/C=C\\CCCCCCCCO.COC(=O)CBr>>CCCCCCCC/C=C\\CCCCCCCCOC(=O)CBr",
        "output": "289"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C[C@H]1CN(c2ccc(Cl)c(N)c2)C[C@@H](C)N1.ClCCl.O=S(=O)(Cl)c1ccc(Br)cc1.c1ccncc1>>C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(Br)cc3)c2)C[C@@H](C)N1",
        "output": "68"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.CS(=O)(=O)N1CCN(C(=O)c2cc3c(=O)[nH]nc(Cl)c3o2)CC1.O.[H-].[Na+]>>Cn1nc(Cl)c2oc(C(=O)N3CCN(S(C)(=O)=O)CC3)cc2c1=O",
        "output": "229"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CO.COP(=O)(CC(C)=O)OC.COc1nc2cc([N+](=O)[O-])cc(CN)c2nc1OC.ClCCl.O=S(=O)([O-])[O-].[BH3-]C#N.[Mg+2].[Na+]>>COc1nc2cc([N+](=O)[O-])cc(CNC(C)CP(=O)(OC)OC)c2nc1OC",
        "output": "589"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCc1cc(CCNCc2ccc(C(C)(C)C)cc2)ccc1Cl.Cc1ccccc1.Cl.O=C(Cl)C(=O)Cl.O=C(O)c1cc(C(F)(F)F)cc(Cl)c1F.O=CN1CCCCC1>>CCc1cc(CCN(Cc2ccc(C(C)(C)C)cc2)C(=O)c2cc(C(F)(F)F)cc(Cl)c2F)ccc1Cl",
        "output": "794"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1ccc2[nH]nc(I)c2c1.ClCCl>>OCc1ccc2[nH]nc(I)c2c1",
        "output": "444"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOc1cccc(CC(=O)OC)c1.CO.[Na+].[OH-]>>CCOc1cccc(CC(=O)O)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CC2(CCN1)COC2.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O.O=C(O)c1ccc(NC(=O)N2Cc3ccccc3C2)nn1>>O=C(Nc1ccc(C(=O)N2CCC3(CC2)COC3)nn1)N1Cc2ccccc2C1",
        "output": "663"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)C1CCN(C(=O)Nc2cnc3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nn23)CC1.CO.O.O.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li+].[OH-]>>O=C(O)C1CCN(C(=O)Nc2cnc3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)nn23)CC1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)c1ccccc1Sc1ccccc1[N+](=O)[O-].[Pd]>>COC(=O)c1ccccc1Sc1ccccc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2ccc([N+](=O)[O-])cn2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=[N+]([O-])c1ccc(OC2CCNCC2)nc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CCCCc1cc(OC)cc(OC)c1.ClCCl>>CCCCc1cc(O)cc(O)c1",
        "output": "20"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=C(O)Cc1ccc(Oc2ccc(F)c(F)c2)nc1.O=C([O-])[O-].O=S(=O)(O)O.[Na+].[Na+]>>CCOC(=O)Cc1ccc(Oc2ccc(F)c(F)c2)nc1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.C[Si](C)(C)C#Cc1cncc(C(=O)N=[S@@](C)(=O)c2ccccc2)c1.O=C([O-])[O-].[K+].[K+]>>C#Cc1cncc(C(=O)N=[S@@](C)(=O)c2ccccc2)c1",
        "output": "337"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](CN)C1.CCN(C(C)C)C(C)C.CCOC(C)=O.CS(C)=O.Cc1cccc(F)c1[N+](=O)[O-]>>Cc1cccc(NC[C@@H]2CCN(C(=O)OC(C)(C)C)C2)c1[N+](=O)[O-]",
        "output": "572"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCOC(=O)CC1OC(c2cccc(OC)c2OC)c2cc(Cl)ccc2-n2c(CCOC)nnc21.Cl>>COCCc1nnc2n1-c1ccc(Cl)cc1C(c1cccc(OC)c1OC)OC2CC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C=C1CCCC1.CO.Cl.[K+].[OH-]>>O=C(O)C=C1CCCC1",
        "output": "122"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)n1c(-c2cc(C(F)(F)F)cc(S(=O)(=O)NC3CCCCC3)c2)cc2ccccc21.O=C(O)C(F)(F)F>>O=S(=O)(NC1CCCCC1)c1cc(-c2cc3ccccc3[nH]2)cc(C(F)(F)F)c1",
        "output": "848"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.ClCCl.O=C(Cl)c1cccc(C(F)(F)F)c1.O[C@@H]1C[C@H]2CNCCN2C1>>O=C(c1cccc(C(F)(F)F)c1)N1CCN2C[C@H](O)C[C@H]2C1",
        "output": "201"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1ccc(NC(=O)c2cc(Br)c3c(c2)C(c2ccc(C)cc2)=CC(C)(C)O3)cc1.CCOC(C)=O.CCOCC.CO.Cl.ClCCl.ClCCl.[Na+].[OH-]>>Cc1ccc(C2=CC(C)(C)Oc3c(Br)cc(C(=O)Nc4ccc(C(=O)O)cc4)cc32)cc1",
        "output": "5"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCOP(=O)(Cc1cc(F)c(F)c(F)c1)OCC.CO.C[Si](C)(C)Br.ClCCl.O>>O=P(O)(O)Cc1cc(F)c(F)c(F)c1",
        "output": "535"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.COCOc1cccc(C(F)(F)C(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c1.Cl.O=C([O-])O.[Na+]>>O=C1CCC(N2Cc3cc(CNC(=O)C(F)(F)c4cccc(O)c4)ccc3C2=O)C(=O)N1",
        "output": "755"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)OCc2cc([C@@H]3CN(CCc4ccc5c(c4)O[C@H](CO)CO5)C(=O)O3)ccc2O1.CCCC[N+](CCCC)(CCCC)CCCC.ClCCl.NC(=O)Nc1cccc(CBr)c1.O.O=S(=O)([O-])O.[Na+].[OH-]>>CC1(C)OCc2cc([C@@H]3CN(CCc4ccc5c(c4)O[C@H](COCc4cccc(NC(N)=O)c4)CO5)C(=O)O3)ccc2O1",
        "output": "464"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C[C@H](Cc1ccccc1)NC(=O)[C@H](C)c1cc(O)cc(C(F)(F)F)c1.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>C[C@H](Cc1ccccc1)NC(=O)[C@H](C)c1cc(OS(=O)(=O)C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "843"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC[C@](C)(N)CO.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.O=C(O)[C@H](CC(F)(F)Cc1ccccc1)NC(=O)N1CCOCC1.On1nnc2ccccc21>>CCC[C@@](C)(CO)NC(=O)[C@H](CC(F)(F)Cc1ccccc1)NC(=O)N1CCOCC1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2nc(C(C)(C)C(F)(F)F)ccc2c1.[Na+].[OH-]>>CC(C)(c1ccc2cc(C(=O)O)ccc2n1)C(F)(F)F",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](O)[C@H]1C(=O)O.CI.CN(C)C=O.O.O=C([O-])[O-].[Cl-].[K+].[K+].[Na+]>>COC(=O)[C@@H]1[C@@H](O)CCN1C(=O)OC(C)(C)C",
        "output": "415"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)OB(c2cnc(N)c(-c3cc4cc(N)ccc4s3)c2)OC1(C)C.CCc1cccc(N=C=O)c1>>CCc1cccc(NC(=O)Nc2ccc3sc(-c4cc(B5OC(C)(C)C(C)(C)O5)cnc4N)cc3c2)c1",
        "output": "473"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(OCc2c(-c3ccccn3)noc2C)nc1.Cl.O.O.[Li+].[OH-]>>Cc1onc(-c2ccccn2)c1COc1ccc(C(=O)O)cn1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COC(=O)c1ccc(CN2CCN(C)CC2)cn1.[BH4-].[Na+]>>CN1CCN(Cc2ccc(CO)nc2)CC1",
        "output": "546"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCCC[C@@H]1C(=O)Nc1ccc(C#Cc2cn(CCO)nc2-c2cc(Cl)ccc2O)cc1.ClCCl.O=C(O)C(F)(F)F>>O=C(Nc1ccc(C#Cc2cn(CCO)nc2-c2cc(Cl)ccc2O)cc1)[C@H]1CCCCN1",
        "output": "634"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(O)CN1CCC(c2ccc(F)cc2)(c2ccc(F)cc2)C1=O.O=C(O)CN1CCCC(c2ccc(F)cc2)(c2ccc(F)cc2)C1=O.c1ccc(C2(c3ccccc3)CCNC2)cc1.c1ccc2c(c1)CCNC2>>O=C(CN1CCC(c2ccc(F)cc2)(c2ccc(F)cc2)C1=O)N1CCc2ccccc2C1",
        "output": "633"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.COC(=O)[C@@H]1C[C@H](N)CN1C(=O)OC(C)(C)C.Cl.ClCCl.On1nnc2ccccc21>>COC(=O)[C@@H]1C[C@H](NC(=O)CNC(=O)OC(C)(C)C)CN1C(=O)OC(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Oc1ccc2cc(C(=O)O)ccc2c1.CN(C)C=O.O=S(Cl)Cl>>CC(=O)Oc1ccc2cc(C(=O)Cl)ccc2c1",
        "output": "3"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C1COCCN1.COc1cccc2c1nc(C(F)F)n2-c1cc(Cl)nc(SC)n1.O>>COc1cccc2c1nc(C(F)F)n2-c1cc(N2CCOCC2)nc(SC)n1",
        "output": "162"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCCCc1oc2ccc([N+](=O)[O-])cc2c1C(=O)c1ccc(O)cc1.ClCC1CO1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CCCCc1oc2ccc([N+](=O)[O-])cc2c1C(=O)c1ccc(OCC2CO2)cc1",
        "output": "15"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(N)=NO.CN1CCN(C(=O)N2CC(C(=O)O)CC(c3ccc(C(F)(F)F)cc3)C2)CC1=O.Cl>>CCc1noc(C2CC(c3ccc(C(F)(F)F)cc3)CN(C(=O)N3CCN(C)C(=O)C3)C2)n1",
        "output": "728"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1cc(Cl)c(N2CCNCC2)cc1N.COc1ccccc1-c1noc(C)c1C(=O)O>>COC(=O)c1cc(Cl)c(N2CCN(C(=O)c3c(-c4ccccc4OC)noc3C)CC2)cc1N",
        "output": "975"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCI.CN(C)C=O.COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2.O.O=C([O-])[O-].[K+].[K+]>>CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1",
        "output": "184"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.COc1c(OC(F)(F)F)cccc1C(O)c1cc(Cl)ccc1N.COc1ccc(C=O)c(OC)c1.[BH4-].[Na+]>>COc1ccc(CNc2ccc(Cl)cc2C(O)c2cccc(OC(F)(F)F)c2OC)c(OC)c1",
        "output": "359"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2ccc(C(=O)O)cc2)CC1.Cl.O=S(=O)(c1ccc2cc(Cl)ccc2c1)N1CCNCC1>>CC(C)(C)OC(=O)N1CCC(c2ccc(C(=O)N3CCN(S(=O)(=O)c4ccc5cc(Cl)ccc5c4)CC3)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC1(C)C[C@@H](N)CC[C@H]1O.CCN(C(C)C)C(C)C.CSc1ncc(C#N)c(Cl)n1>>CSc1ncc(C#N)c(N[C@H]2CC[C@@H](O)C(C)(C)C2)n1",
        "output": "166"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=O.CCOc1ccc(C(=O)Nc2ccc3c(c2Cl)CNCC3)cc1Br.O=CO.[Na+].[OH-]>>CCOc1ccc(C(=O)Nc2ccc3c(c2Cl)CN(C)CC3)cc1Br",
        "output": "69"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.NN.O.O=C1c2ccccc2C(=O)N1Cc1cc(-c2ccc(C3CC3)nc2)ncn1>>NCc1cc(-c2ccc(C3CC3)nc2)ncn1",
        "output": "242"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC12CCC(=O)C=C1c1c(cc(OCC(=O)OC(C)(C)C)c(Cl)c1Cl)C2.CCCC12CCC(=O)C=C1c1c(cc(OCC(=O)OC(C)(C)C)c(Cl)c1Cl)C2>>CCCC12CCC(=O)C=C1c1c(cc(OCC(=O)O)c(Cl)c1Cl)C2",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCCO.Oc1nc(Cl)nc2cnccc12>>COCCOc1nc(O)c2ccncc2n1",
        "output": "37"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O.CC1(C)CC(=O)CC(C)(C)N1OC1CCCCC1.CCCCCCCCCCCCN.[BH3-]C#N.[Na+]>>CCCCCCCCCCCCNC1CC(C)(C)N(OC2CCCCC2)C(C)(C)C1",
        "output": "236"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.O=Cc1cc2nc(Cl)ccc2n1Cc1ccccc1.[BH4-].[Na+]>>OCc1cc2nc(Cl)ccc2n1Cc1ccccc1",
        "output": "745"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.C[C@@H]1CN(C(=O)c2ccc(-n3cccn3)cc2)c2ccccc2CN1C(=O)NCC(=O)O.Cl.O.O.Oc1cccc2[nH]nnc12.[Cl-].[NH4+]>>C[C@@H]1CN(C(=O)c2ccc(-n3cccn3)cc2)c2ccccc2CN1C(=O)NCC(N)=O",
        "output": "313"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)CC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOCC.Cc1ccccc1.Fc1ccc(CBr)cc1.O.O=S(=O)([O-])O.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(OCc2ccc(F)cc2)CC1",
        "output": "464"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1cccc(N2CCC(N3CCOCC3)CC2)c1.C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2cccc(N3CCC(N4CCOCC4)CC3)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCC(=O)O.CCN=C=NCCCN(C)C.CN1CCOCC1.CNOC.Cl.Cl.ClCCl.On1nnc2ccccc21>>CCCCC(=O)N(C)OC",
        "output": "54"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.O=C(Nc1ccccc1)OCCCC(O)c1ccccc1.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>O=C(Nc1ccccc1)OCCCC(=O)c1ccccc1",
        "output": "32"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COCCOC.Cc1ncc(-c2cccc(Nc3nccc4c(Br)cccc34)c2)n1C.O=C([O-])[O-].OB(O)c1ccc(F)cc1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1ncc(-c2cccc(Nc3nccc4c(-c5ccc(F)cc5)cccc34)c2)n1C",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COC(=O)c1ccc(-c2nc(CCl)c(C)o2)cc1.Cc1ccc(O)cc1.O.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)c1ccc(-c2nc(COc3ccc(C)cc3)c(C)o2)cc1",
        "output": "760"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCSc1ccccc1-c1ccc2nc(C(F)(F)C(F)(F)F)cn2c1C.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>CCS(=O)c1ccccc1-c1ccc2nc(C(F)(F)C(F)(F)F)cn2c1C",
        "output": "500"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)Cn1c(C)c(Cc2ccccc2S(=O)(=O)N(C)c2ccccc2)c2c1CC(C)(C)CC2=O.O.[Na+].[OH-]>>Cc1c(Cc2ccccc2S(=O)(=O)N(C)c2ccccc2)c2c(n1CC(=O)O)CC(C)(C)CC2=O",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NCCC[C@H]1COCc2nc3cnc4ccccc4c3n21.ClCCl.O=C(OO)c1cccc(Cl)c1.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)OC(=O)NCCC[C@H]1COCc2nc3c[n+]([O-])c4ccccc4c3n21",
        "output": "820"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NC1CCOCC1CO.CCCCP(CCCC)CCCC.Cc1ccccc1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.Oc1ccc(-c2ccc(Cl)cn2)cc1.[Na+].[OH-]>>CC(C)(C)OC(=O)NC1CCOCC1COc1ccc(-c2ccc(Cl)cn2)cc1",
        "output": "550"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CNCCN1.O=S1CCN(c2nc(Cl)nc3c(SCc4ccccc4Cl)ncnc23)CC1>>O=S1CCN(c2nc(N3CCNCC3)nc3c(SCc4ccccc4Cl)ncnc23)CC1",
        "output": "36"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccnc(NC2CN(C(=O)OC(C)(C)C)C2)c1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccnc(NC2CNC2)c1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CNC(=O)c1ccc(Cl)nc1.CS(C)=O.Oc1ccc2c(c1)CCN(C1CCC1)CC2.[H-].[Na+]>>CNC(=O)c1ccc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)nc1",
        "output": "516"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCNCC1.F[P-](F)(F)(F)(F)F.O=C(O)C1CC12CCN(C(=O)OCc1ccccc1)CC2>>CN1CCN(C(=O)C2CC23CCN(C(=O)OCc2ccccc2)CC3)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CC2(CC2)CN1.O=C(O)C1CCc2c(sc3ncnc(Cl)c23)C1>>O=C(C1CCc2c(sc3ncnc(Cl)c23)C1)N1CCC2(CC2)C1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2nccnc2Cl)CC1.CN(C)C=O.OCCOc1cccc(O)c1.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCN(c2nccnc2OCCOc2cccc(O)c2)CC1",
        "output": "209"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNCC1.CCO.Cc1[nH]c(C=O)c(C)c1CN(C)C1CC1.O=C1Cc2cc(S(=O)(=O)Cc3ccccc3OCCN3CCOCC3)ccc2N1>>Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4ccccc4OCCN4CCOCC4)cc32)c(C)c1CN(C)C1CC1",
        "output": "911"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.COc1ccccc1N1CCN(CCc2ccc(O)c3c2CCCN3)CC1>>COc1ccccc1N1CCN(CCc2ccc(O)c3c2CCCN3C(C)=O)CC1",
        "output": "160"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.Cc1ccc(S(=O)(=O)Nc2c(C)cccc2C)cc1.O.O=N[O-].O=[N+]([O-])O.[Na+]>>Cc1ccc(S(=O)(=O)Nc2c(C)cc([N+](=O)[O-])cc2C)cc1",
        "output": "21"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1cnc2cn[nH]c2c1.O.[Na+].[OH-]>>O=C(O)c1cnc2cn[nH]c2c1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.COc1ccc(N2CCN[C@@H](Cc3ccccc3)C2)cc1OC1CCCC1.c1ccncc1>>COc1ccc(N2CCN(C(C)=O)[C@@H](Cc3ccccc3)C2)cc1OC1CCCC1",
        "output": "369"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCc1cc2c3ccccc3ccc2c2ccccc12.C1CCOC1.CC(N)(CO)CO.CCN(CC)CC>>CC(CO)(CO)NCc1cc2c3ccccc3ccc2c2ccccc12",
        "output": "446"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cc(NC(=O)c2c(Cl)cccc2Cl)ccn1.O=C(O)[C@@H]1C[C@H]1C(=O)O>>O=C(Nc1ccnc(NC(=O)[C@@H]2C[C@H]2C(=O)O)c1)c1c(Cl)cccc1Cl",
        "output": "368"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)c1ccncc1.COC[C@@H]1CN(CCN2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](Cc3ccc(C)c(N)c3)C2)CCO1.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COC[C@@H]1CN(CCN2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](Cc3ccc(C)c(NC(=O)C(F)(F)F)c3)C2)CCO1",
        "output": "106"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCc1cc(C(=O)CC)c(O)c(CCC)c1OC(C(=O)OC)c1ccccc1.[Na+].[OH-]>>CCCc1cc(C(=O)CC)c(O)c(CCC)c1OC(C(=O)O)c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.COC(=O)Oc1cc(Nc2ncnc3cc(N)ccc23)c(F)cc1C.COCC(=O)Cl.Cl.ClCCl>>COCC(=O)Nc1ccc2c(Nc3cc(OC(=O)OC)c(C)cc3F)ncnc2c1",
        "output": "9"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)CC(C)C=CC1CCCC1.CCOCC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC(C=CC1CCCC1)CCO",
        "output": "225"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.COc1ccc2[nH]cc(CCNC(=O)C3CC3)c2c1.O=C1CCC(=O)N1Br.[Na+].[OH-]>>COc1ccc2[nH]c(Br)c(CCNC(=O)C3CC3)c2c1",
        "output": "779"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1ccc(Oc2ccc3c(c2)CCC(c2ccccc2)O3)nc1.O=[N+]([O-])c1ccc(Oc2ccc3c(c2)CCC(c2ccc(C(F)(F)F)cc2)O3)nc1>>Nc1ccc(Oc2ccc3c(c2)CCC(c2ccc(C(F)(F)F)cc2)O3)nc1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)CNc1ccc(C(CC)=NOCc2ccc(C(F)(F)F)cc2)cc1.O.[Li+].[OH-]>>CCC(=NOCc1ccc(C(F)(F)F)cc1)c1ccc(NCC(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)o1.[H][H].[Pd]>>COc1nn(-c2ccc(N)cc2)c(=O)o1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CC(C)(C)OC(=O)N1C[C@@H](O)C[C@H]1c1ncc(-c2ccc(Br)cc2)[nH]1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CS(C)=O.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(C)OC(=O)N1C[C@@H](O)C[C@H]1c1ncc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)[nH]1",
        "output": "942"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C[C@@H](OC(=O)Nc1c(F)cnn1-c1ccc(Br)cc1)c1ccccc1Cl.Cc1cc(C2(C(=O)O)CC2)ccc1B(O)O>>Cc1cc(C2(C(=O)O)CC2)ccc1-c1ccc(-n2ncc(F)c2NC(=O)O[C@H](C)c2ccccc2Cl)cc1",
        "output": "837"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CN(C)C=O.FC(F)(F)c1cc(OCc2ccccc2)ccc1Br.[Li]CCCC>>O=Cc1ccc(OCc2ccccc2)cc1C(F)(F)F",
        "output": "638"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCc1cnc(-c2cnc(Cl)c(Cl)c2)o1.CN(C)C=O.O=C(O)C1CNC1>>CCc1cnc(-c2cnc(N3CC(C(=O)O)C3)c(Cl)c2)o1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(=O)Cl.Cc1[nH]c2c(-c3cc(C(F)F)ccc3OCC3CC3)ncnc2c1C(=O)NC1CCNCC1.Cl>>CCC(=O)N1CCC(NC(=O)c2c(C)[nH]c3c(-c4cc(C(F)F)ccc4OCC4CC4)ncnc23)CC1",
        "output": "125"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1c(N2CCC(C)(NC(=O)OC(C)(C)C)C2)c(F)c(N)c2c(=O)c(C(=O)O)cn(C3CC3)c12.Cl.O.[K+].[OH-]>>Cc1c(N2CCC(C)(N)C2)c(F)c(N)c2c(=O)c(C(=O)O)cn(C3CC3)c12",
        "output": "538"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.C[C@H](N)c1cccc(Br)c1.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)c([N+](=O)[O-])c1>>C[C@H](NS(=O)(=O)c1ccc([N+](=O)[O-])cc1[N+](=O)[O-])c1cccc(Br)c1",
        "output": "530"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC(C)(C)c1ccc(N)c(F)c1.O.O=S([O-])([O-])=S.O=S([O-])OO.[Br-].[K+].[Na+].[Na+].[Na+]>>CC(C)(C)c1cc(F)c(N)c(Br)c1",
        "output": "784"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.COc1ccc2ccc(F)c(CCCO)c2n1>>COc1ccc2ccc(F)c(CCC=O)c2n1",
        "output": "142"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1ccn(-c2cnc(Nc3cnc(C#N)cn3)cc2NCC2CCCN(C(=O)OC(C)(C)C)C2)c1.CO>>CCOC(=O)c1ccn(-c2cnc(Nc3cnc(C#N)cn3)cc2NCC2CCCNC2)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1NCCc2sc(Br)cc21.O=C(O)c1cc2ncc(Br)cn2n1>>CN1c2cc(Br)sc2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "995"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CCO.CN(c1ccccc1CNc1nc(-c2cc(F)c(OCOCC[Si](C)(C)C)cc2CC(F)(F)F)cc2c1c(C(N)=O)nn2COCC[Si](C)(C)C)S(=O)(=O)CCCCl>>CN(c1ccccc1CNc1nc(-c2cc(F)c(OCOCC[Si](C)(C)C)cc2CC(F)(F)F)cc2c1c(C(N)=O)nn2COCC[Si](C)(C)C)S(=O)(=O)CCCN1CCOCC1",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCOC(=O)Cl.ClCCl.Nc1ccc([N+](=O)[O-])c(N)c1.O.O=C([O-])O.[Na+]>>CCOC(=O)Nc1ccc([N+](=O)[O-])c(N)c1",
        "output": "102"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClC(Cl)Cl.O=C(O)c1cc(Cl)cc2c1OCCN2.O=C([O-])O.[Na+]>>CC(=O)N1CCOc2c(C(=O)O)cc(Cl)cc21",
        "output": "160"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COCCBr.COc1cc2nc(-c3cccc(NC(=O)c4cccnc4)c3)nc(Nc3ccc4c(cnn4C(=O)OC(C)(C)C)c3)c2cc1O.O=C([O-])[O-].[K+].[K+]>>COCCOc1cc2c(Nc3ccc4c(cnn4C(=O)OC(C)(C)C)c3)nc(-c3cccc(NC(=O)c4cccnc4)c3)nc2cc1OC",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CCCCCN(C)C(=O)[C@@H]1CC[C@@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C[C@H]1C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>C=CCCCCN(C)C(=O)[C@@H]1CC[C@@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C[C@H]1C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)O.CC(C)(C)OC(=O)N1CCC[C@H](N)C1.CC(Cl)Cl.CCCCCC.CCN(CC)CC.CCOC(C)=O.FC(F)(F)c1cnc(Cl)nc1Cl.[Cl-].[Cl-].[Zn+2]>>CC(C)(C)OC(=O)N1CCC[C@H](Nc2ncc(C(F)(F)F)c(Cl)n2)C1",
        "output": "544"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(=O)OC(C)(C)C)C(C)(C)C=C(C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21.ClCCl.O=C(O)C(F)(F)F>>CCNC(C)(C)C=C(C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21",
        "output": "800"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.NCc1cc(C(F)(F)F)on1.O=C(O)c1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1>>O=C(NCc1cc(C(F)(F)F)on1)c1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1cc(Sc2ccc(C=O)c(C)n2)ccc1Br.ClCCl.O.O=C([O-])O.[Cl-].[Na+].[Na+].[Na+]>>Cc1cc(Sc2ccc(CO)c(C)n2)ccc1Br",
        "output": "476"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC(C(=O)OCc1ccccc1)C1(O)CCC1.CCO.[Pd]>>CC(C)(C)OC(=O)NC(C(=O)O)C1(O)CCC1",
        "output": "186"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1ccc(CCl)cc1.CCN(CC)CC.CN(C)C=O.O.O=C(NC(=O)c1ccccc1)NC1CCNCC1>>CC(C)c1ccc(CN2CCC(NC(=O)NC(=O)c3ccccc3)CC2)cc1",
        "output": "156"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)NC1CCCCN(C(=O)OC(C)(C)C)C1.COCCCCN1C(=O)C(C)(C)Oc2cc(C(F)(F)F)c(C(=O)O)cc21>>COCCCCN1C(=O)C(C)(C)Oc2cc(C(F)(F)F)c(C(=O)N(C(C)C)C3CCCCN(C(=O)OC(C)(C)C)C3)cc21",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)Cc1cccc(C2OCCO2)c1.CCCCCC.CCOC(C)=O.CCOC(C)=O.N.O=S(=O)(O)O>>CC(C)(C)Cc1cccc(C=O)c1",
        "output": "655"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)c1ccc(N2CCC(c3ccccc3)CC2)cc1NC(=O)c1ccccc1.O=C(O)C(F)(F)F>>O=C(Nc1cc(N2CCC(c3ccccc3)CC2)ccc1C(=O)O)c1ccccc1",
        "output": "752"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CS(=O)(=O)Cl.N#CCOc1cccc(N)c1.c1ccncc1>>CS(=O)(=O)Nc1cccc(OCC#N)c1",
        "output": "194"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "N#Cc1c(F)cccc1F.O=C1NCCCC1(CO)C(=O)NC1CCCCC1>>N#Cc1c(F)cccc1OCC1(C(=O)NC2CCCCC2)CCCNC1=O",
        "output": "485"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.O=[N+]([O-])c1ccc(Oc2ncnn3cc(-c4ccnc(N5CCOCC5)c4)cc23)c(F)c1.[Cl-].[NH4+].[Zn]>>Nc1ccc(Oc2ncnn3cc(-c4ccnc(N5CCOCC5)c4)cc23)c(F)c1",
        "output": "335"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.NCc1ccccc1Cl.O=C(O)CN1C(=O)C(c2ccc(C(F)(F)F)cc2)=NC12CCCC2>>O=C(CN1C(=O)C(c2ccc(C(F)(F)F)cc2)=NC12CCCC2)NCc1ccccc1Cl",
        "output": "599"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.COCOc1c(N)cc(C(C)=O)cc1C(C)(C)C>>COCOc1c(NC(C)=O)cc(C(C)=O)cc1C(C)(C)C",
        "output": "9"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.Cn1c(C(F)(F)F)cc(=O)n(-c2cc(N)c(Cl)cc2F)c1=O.c1ccccc1>>CC(=O)Nc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl",
        "output": "6"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C([O-])[O-].O=S(=O)(Cc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1)c1ccc(F)cc1.[K+].[K+]>>O=S(=O)(Cc1ccc(C(OCc2ccccc2)(C(F)(F)F)C(F)(F)F)cc1)c1ccc(F)cc1",
        "output": "464"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(C)(O)CC(=O)Nc1ccc2c(c1)CCNC2.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)COc1cccnc1>>CCC(C)(O)CC(=O)Nc1ccc2c(c1)CCN(C(=O)COc1cccnc1)C2",
        "output": "633"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "N=C(NO)[C@H]1CCCN(C(=O)c2ccc(F)cc2)C1.O=C(O)Cc1ccccc1>>O=C(c1ccc(F)cc1)N1CCC[C@H](c2noc(Cc3ccccc3)n2)C1",
        "output": "924"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.CC(C)(C(=O)C(=O)O)c1ccccc1.ClC(Cl)(Cl)Cl.[Fe]>>CC(C)(C(=O)C(=O)O)c1ccc(Br)cc1",
        "output": "98"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O.O=C1c2ccccc2C(=O)c2c1cccc2[N+](=O)[O-].[Na+].[Na+].[S-2]>>Nc1cccc2c1C(=O)c1ccccc1C2=O",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc2ncnc(Sc3cccc(N)c3)c2cc1OC.O=C=Nc1ccc(C(F)(F)F)cc1>>COc1cc2ncnc(Sc3cccc(NC(=O)Nc4ccc(C(F)(F)F)cc4)c3)c2cc1OC",
        "output": "473"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrBr.CC(=O)O.CC(=O)c1ccc(OCC(=O)O)cc1>>O=C(O)COc1ccc(C(=O)CBr)cc1",
        "output": "173"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CO.CSc1ccc(CCC(=O)O)cc1.O=C(n1ccnc1)n1ccnc1>>COC(=O)CCc1ccc(SC)cc1",
        "output": "195"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCO.CC[O-].Clc1ccnc(Cl)n1.[Na+]>>CCOc1ccnc(Cl)n1",
        "output": "653"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(CC(=O)O)N1C(=O)c2ccccc2C1=O.NNC1=Nc2ccc(Cl)cc2C(c2ccccc2F)=NC1.O=C(n1ccnc1)n1ccnc1>>CC(CC(=O)NNC1=Nc2ccc(Cl)cc2C(c2ccccc2F)=NC1)N1C(=O)c2ccccc2C1=O",
        "output": "459"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)Cc1cn(Cc2ccccc2)cn1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCc1cn(Cc2ccccc2)cn1",
        "output": "225"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCBr.CCO.O.OCc1ccccc1O.[Na+].[OH-]>>CCCCOc1ccccc1CO",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.COc1ccc(N=Nc2c(S(=O)(=O)OC(C)C)cc3cc(Nc4nc(Cl)nc(Cl)n4)ccc3c2O)cc1.Cl.O=C([O-])[O-].OCCNCCO.[Na+].[Na+]>>COc1ccc(N=Nc2c(S(=O)(=O)OC(C)C)cc3cc(Nc4nc(Cl)nc(N(CCO)CCO)n4)ccc3c2O)cc1",
        "output": "214"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.N#Cc1cc(S(=O)(=O)Cl)ccc1F.NCc1ccccn1>>N#Cc1cc(S(=O)(=O)NCc2ccccn2)ccc1F",
        "output": "43"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(O)(CCc1ccc(Cl)cc1)Cn1ccnc1.CN(C)C=O.O=[N+]([O-])c1ccc(F)cc1.[H-].[H][H].[Mn+4].[Na+].[O-2].[O-2].c1ccccc1>>CC(CCc1ccc(Cl)cc1)(Cn1ccnc1)Oc1ccc([N+](=O)[O-])cc1",
        "output": "485"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)OC(=O)/N=N/C(=O)OC(C)C.COC(=O)c1ccccc1COc1cccc(CCO)c1.Cc1ccccc1.Oc1ccc(OCc2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1ccccc1COc1cccc(CCOc2ccc(OCc3ccccc3)cc2)c1",
        "output": "478"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)c1n[nH]c2c1CCCC2.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1n[nH]c2c1CCCC2",
        "output": "391"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCCCBr.CN(C)C=O.Clc1cccc2cc[nH]c12.O.[K+].[OH-]>>Clc1cccc2ccn(CCCBr)c12",
        "output": "470"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CN(C)C=O.COc1ccc(CO)cc1.CSc1nc(Cl)cc(Cl)n1.O.[H-].[Na+]>>COc1ccc(COc2cc(Cl)nc(SC)n2)cc1",
        "output": "653"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1[nH]c2ccccc2c1C(=O)N1CCC2(CC1)OCc1ccccc12.O=C(Cl)c1ccccc1.[H-].[Na+]>>Cc1c(C(=O)N2CCC3(CC2)OCc2ccccc23)c2ccccc2n1C(=O)c1ccccc1",
        "output": "232"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCCC.CCOC(C)=O.CI.COCC(CO)(COC1C2CC3CC(C2)CC1C3)C1CCCCC1.[H-].[Na+]>>COCC(COC)(COC1C2CC3CC(C2)CC1C3)C1CCCCC1",
        "output": "140"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OCc1c(F)c(N)c2c(=O)cc(-c3ccc(N)c(F)c3)oc2c1F.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.O=C(O)CCBr>>CC(=O)OCc1c(F)c(N)c2c(=O)cc(-c3ccc(NC(=O)CCBr)c(F)c3)oc2c1F",
        "output": "365"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)C1CCc2sc(-c3ccc(OCCCCl)cc3)nc2C1.O.O.[Li+].[OH-]>>O=C(O)C1CCc2sc(-c3ccc(OCCCCl)cc3)nc2C1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.Cc1ccc(O)cc1C.O.O=[N+]([O-])O>>Cc1ccc(O)c([N+](=O)[O-])c1C",
        "output": "21"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CN(C2CCOCC2)CCN1.CC#N.CCN(C(C)C)C(C)C.CCc1nccc(-c2ccc(C(=O)O)c(F)c2)c1C#Cc1ccc(NC)nc1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O>>CCc1nccc(-c2ccc(C(=O)N3CCN(C4CCOCC4)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)O.Cc1ccc(S(=O)(=O)n2ccc3c(Nc4ccc5c(cnn5C)c4)nc(Nc4ccc(C(N)=O)cc4)nc32)cc1.[K+].[OH-]>>Cn1ncc2cc(Nc3nc(Nc4ccc(C(N)=O)cc4)nc4[nH]ccc34)ccc21",
        "output": "949"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1ccc(CCCC2CCNCC2)cc1.COc1ccc(COC(=O)[C@@H](C2CCCCC2)N2C[C@H](C=O)[C@@H](c3ccccc3)C2)cc1.O=C(O)C(F)(F)F>>COC(=O)c1ccc(CCCC2CCN(C[C@H]3CN([C@@H](C(=O)OCc4ccc(OC)cc4)C4CCCCC4)C[C@@H]3c3ccccc3)CC2)cc1",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.Cc1ccc(S(=O)(=O)OCCCCc2c[nH]c3ccc(C#N)cc23)cc1.O=C([O-])[O-].O=c1c2ccoc2ccn1-c1ccc(N2CCNCC2)cc1.[I-].[K+].[K+].[K+]>>N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(-n5ccc6occc6c5=O)cc4)CC3)c2c1",
        "output": "429"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cc(-c2ccc3cc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)ccc3c2)ccc1Cl.[Na+].[OH-]>>CC(C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc2cc(-c3ccc(Cl)c(C(=O)O)c3)ccc2c1",
        "output": "5"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(B2OC(C)(C)C(C)(C)O2)c(F)c1.N#Cc1nc(N)ccc1Br>>CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2ccc(N)nc2C#N)c(F)c1",
        "output": "938"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.CC(O)c1ccccc1.N#Cc1ccc(O)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(Oc1ccc(C#N)cc1)c1ccccc1",
        "output": "342"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCNCC3)C2=O)c1.CCC(C)=O.O=C([O-])[O-].O=C1N(CCCCl)c2ccccc2C1(F)F.[I-].[K+].[K+].[Na+]>>CC(C)(C)OC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCN(CCCN4C(=O)C(F)(F)c5ccccc54)CC3)C2=O)c1",
        "output": "138"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)CSc1cccc(OC(C)=O)c1CC(=O)OCC.N>>CCOC(=O)CSc1cccc(O)c1CC(=O)OCC",
        "output": "22"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CNCC12CCC2.ClCCl.O.O=C(Cl)OCc1ccccc1.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)OC(=O)N[C@@H]1CN(C(=O)OCc2ccccc2)CC12CCC2",
        "output": "427"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1ncn2c1[C@@H]1CCN1C(=O)c1c(Cl)cccc1-2.Cl.O.[BH4-].[Li+]>>O=C1c2c(Cl)cccc2-n2cnc(CO)c2[C@@H]2CCN12",
        "output": "286"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1ccc(C2CC(N)CN(C(=O)N3CCCC3)C2)cc1.O=C(O)C(F)(F)F.O=C(O)c1ccc(-c2cccc(F)c2)cn1>>CCc1ccc(C2CC(NC(=O)c3ccc(-c4cccc(F)c4)cn3)CN(C(=O)N3CCCC3)C2)cc1",
        "output": "137"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=C(O)Cc1cccc(Br)c1>>CCOC(=O)Cc1cccc(Br)c1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)CCCl.CN(C)C=O.Sc1ccc(Br)cc1.[H-].[Na+]>>CC(C)(C)CCSc1ccc(Br)cc1",
        "output": "460"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1C(=O)CCc2cc(B3OC(C)(C)C(C)(C)O3)c(F)cc21.OCc1cncc(Br)c1>>CN1C(=O)CCc2cc(-c3cncc(CO)c3)c(F)cc21",
        "output": "938"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=[N+]=[N-].CCCCC(OCC(=O)O)c1ccco1.CCOCC.CN(N=O)C(=N)N[N+](=O)[O-].[K+].[OH-]>>CCCCC(OCC(=O)OC)c1ccco1",
        "output": "60"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C(=O)Oc1ccc(F)cc1)[C@@H]1CNC[C@H]1c1ccc(Cl)cc1.N#CC1CCC(C(=O)O)CC1>>CN(C(=O)Oc1ccc(F)cc1)[C@@H]1CN(C(=O)C2CCC(C#N)CC2)C[C@H]1c1ccc(Cl)cc1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=Cc1cc(O[Si](C)(C)C(C)(C)C)cc2nc(-c3ccc(O[Si](C)(C)C(C)(C)C)c(F)c3)oc12.CC(=O)O.CCOC(C)=O.O.O=C([O-])O.[Na+]>>C=Cc1cc(O[Si](C)(C)C(C)(C)C)cc2nc(-c3ccc(O)c(F)c3)oc12",
        "output": "754"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.CC1(NC(=O)OC(C)(C)C)CCCNC1.CCN(CC)CC.O=[N+]([O-])c1cnc2c(c1Cl)CCC2>>CC1(NC(=O)OC(C)(C)C)CCCN(c2c([N+](=O)[O-])cnc3c2CCC3)C1",
        "output": "398"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1cc(Cl)ccn1.O.O=S(=O)(O)O.O=[N+]([O-])O>>Nc1nccc(Cl)c1[N+](=O)[O-]",
        "output": "328"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNCC1.CCO.NN1C(=O)CSC1=S.O=Cc1ccc(Oc2ccccc2)cc1>>NN1C(=O)C(=Cc2ccc(Oc3ccccc3)cc2)SC1=S",
        "output": "314"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.Cl.Cn1c(Nc2c(Cl)ccc(CNC(=O)OC(C)(C)C)c2Cl)nc2cc(Cl)c(N3CCCC(C(F)(F)F)C3)cc21>>Cn1c(Nc2c(Cl)ccc(CN)c2Cl)nc2cc(Cl)c(N3CCCC(C(F)(F)F)C3)cc21",
        "output": "793"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CCO.COc1cc(Nc2nc(-c3cnc4c(c3)NCCO4)cn3ccnc23)ccc1N1CCC(=O)CC1.Cl.NO.[Na+]>>COc1cc(Nc2nc(-c3cnc4c(c3)NCCO4)cn3ccnc23)ccc1N1CCC(=NO)CC1",
        "output": "86"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.Cc1cc(C)c(C)c(O)c1.ClCCl.O.c1ccncc1>>CC(=O)Oc1cc(C)cc(C)c1C",
        "output": "46"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.Cl.ClCCl.NCC(F)(F)F.O.O=C(O)c1cc(Cl)ccn1.On1nnc2ccccc21>>O=C(NCC(F)(F)F)c1cc(Cl)ccn1",
        "output": "137"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)N1CCN(C(=O)[C@@H]2CC[C@@H](N)CC2)CC1.CCN(C(C)C)C(C)C.N#Cc1ccc(Cl)nc1>>CC(C)N1CCN(C(=O)[C@@H]2CC[C@@H](Nc3ccc(C#N)cn3)CC2)CC1",
        "output": "70"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COCCOc1cc2c(Nc3ccc4c(cnn4C(=O)OC(C)(C)C)c3)nc(-c3cccc(OCC(=O)NC(C)C)c3)nc2cc1OC.ClCCl.O=C(O)C(F)(F)F>>COCCOc1cc2c(Nc3ccc4[nH]ncc4c3)nc(-c3cccc(OCC(=O)NC(C)C)c3)nc2cc1OC",
        "output": "896"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.CN(C)C=O.COC(=O)[C@@H]1CC2(CC[C@H]1C(=O)O)OCCO2.O=C([O-])[O-].[K+].[K+]>>COC(=O)[C@@H]1CC2(CC[C@H]1C(=O)OCc1ccccc1)OCCO2",
        "output": "403"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.ClC(Cl)Cl.O=C(O)Cc1cccc(O)c1.O=S(=O)(O)O>>COC(=O)Cc1cccc(O)c1",
        "output": "17"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrP(Br)Br.C1CCOC1.CCOc1cccc(OCC)c1CO>>CCOc1cccc(OCC)c1CBr",
        "output": "300"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCCOCCOCCOCCC(=O)O.O=C(NCc1cccc(C(F)(F)F)c1)c1ccnc(-c2cc(N3CCCCC3)ccc2NC(=O)c2cccc(Cn3ccc4c(C(=O)O)cccc43)c2)c1>>O=C(O)CCOCCOCCOCCNC(=O)c1cccc2c1ccn2Cc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)C1(C)CSC(c2ccc(F)cc2)=N1.O.[K+].[OH-]>>CC1(C(=O)O)CSC(c2ccc(F)cc2)=N1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1CNCC(C)N1.ClCCl>>CC1CN(C(=O)OC(C)(C)C)CC(C)N1",
        "output": "694"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CCN(CC)CC.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C.ClCCl.F[P-](F)(F)(F)(F)F.O.[Na+].[OH-]>>COc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCN(CC)CC.CN.Cl.O=C(O)C1CN(C(c2ccccc2)c2ccccc2)C1.O=C(n1ccnc1)n1ccnc1>>CNC(=O)C1CN(C(c2ccccc2)c2ccccc2)C1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)c1cc2c(c(C3=CCCC3)c1C(O)c1ccc(C(F)(F)F)cc1)C(=O)CC(C)(C)O2.CO.N[C@@H]1c2ccccc2C[C@@H]1O>>CC(C)c1cc2c(c(C3CCCC3)c1C(O)c1ccc(C(F)(F)F)cc1)C(=O)CC(C)(C)O2",
        "output": "249"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.OC[C@]12CN(Cc3ccccc3)C[C@H]1c1ccccc12.Oc1ccc2c(c1)OCO2.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>c1ccc(CN2C[C@H]3c4ccccc4[C@@]3(COc3ccc4c(c3)OCO4)C2)cc1",
        "output": "550"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C1CCc2cccc(Nc3ncc(-c4ccc(C(F)(F)F)cc4)o3)c2C1.O=C1CCc2cccc(Nc3ncc(-c4ccc(Cl)cc4)o3)c2C1>>OC1CCc2cccc(Nc3ncc(-c4ccc(Cl)cc4)o3)c2C1",
        "output": "91"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc(SCCCCOc2ccc3c(c2)C(C)(C)OC(=O)N3)cc1C.OO>>Cc1ccc(S(=O)CCCCOc2ccc3c(c2)C(C)(C)OC(=O)N3)cc1C",
        "output": "199"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CN1CCOCC1.Cl.F[P-](F)(F)(F)(F)F.N#Cc1cnc2ccc(NCC(=O)O)cc2c1Nc1ccc(F)c(Cl)c1>>CNC(=O)CNc1ccc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cl.N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3OC(F)(F)F)CN2)CC1.O=C(O)C1(N2CCCCC2)CC1>>N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3OC(F)(F)F)CN2C(=O)C2(N3CCCCC3)CC2)CC1",
        "output": "297"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1cccc2ccccc12.Clc1ccc(Cl)cc1.[H][H]>>CCc1cccc2ccccc12",
        "output": "92"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)c1ccc(N2CCNCC2)cc1.CCOC(=O)Nc1nc2ccc(Cl)cc2nc1OC>>COc1nc2cc(Cl)ccc2nc1NC(=O)N1CCN(c2ccc(C(C)=O)cc2)CC1",
        "output": "613"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.FC(F)(F)c1cccc(CNc2nc(Cl)nc3ccc(C(c4ccc(Cl)cc4)c4ccc(Cl)cc4)cc23)c1.OCC(CO)CO.[H-].[Na+]>>OCC(CO)COc1nc(NCc2cccc(C(F)(F)F)c2)c2cc(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)ccc2n1",
        "output": "37"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrC(Br)(Br)Br.C1CCOC1.CC[Si](CC)(CC)c1[nH]c2cc(Cl)c(Cl)cc2c1CCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC[Si](CC)(CC)c1[nH]c2cc(Cl)c(Cl)cc2c1CCBr",
        "output": "378"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.CN(C)C=O.CN(c1ccc(Cl)nn1)C1CC(C)(C)NC(C)(C)C1.COc1cc(C(=O)O)ccc1B(O)O.ClCCl.Cl[Pd]Cl.O.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1cc(C(=O)O)ccc1-c1ccc(N(C)C2CC(C)(C)NC(C)(C)C2)nn1",
        "output": "866"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.II.OCC(O)COc1cc(Oc2ccc(F)cc2F)cc2[nH]ncc12.[K+].[OH-]>>OCC(O)COc1cc(Oc2ccc(F)cc2F)cc2[nH]nc(I)c12",
        "output": "923"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCC(Oc2cccc3ncnc(Cl)c23)CC1.Cc1c[nH]c2ccc(N)cc12>>Cc1c[nH]c2ccc(Nc3ncnc4cccc(OC5CCN(C)CC5)c34)cc12",
        "output": "352"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C3(N)COC3)s2)c1.ClCCl>>Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C3(NS(C)(=O)=O)COC3)s2)c1",
        "output": "493"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CNCCN1.CC#N.CCOC(C)=O.O=[N+]([O-])c1ccc(F)c(F)c1>>O=[N+]([O-])c1ccc(N2CCNCC2)c(F)c1",
        "output": "26"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)CCCCCCCCCCCCCCC(=O)O.CC(C)(C)OC(=O)N[C@@H](CCCCN)C(=O)O.CN(C)C(ON1C(=O)CCC1=O)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F>>CC(C)(C)OC(=O)CCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)O",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](OC1CCC(C2CCNC2=O)CC1)(c1ccccc1)c1ccccc1.CCOCC.CN(C)C=O.Clc1cc(OCc2ccccc2)cc(Cl)c1CBr.[H-].[Na+]>>CC(C)(C)[Si](OC1CCC(C2CCN(Cc3c(Cl)cc(OCc4ccccc4)cc3Cl)C2=O)CC1)(c1ccccc1)c1ccccc1",
        "output": "774"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=C(CN1CCCCC1)C1(c2ccc(Cl)c(Cl)c2)CCCC1.[BH4-].[Na+]>>OC(CN1CCCCC1)C1(c2ccc(Cl)c(Cl)c2)CCCC1",
        "output": "91"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Nc1cccc(C2CCN(CCCN)CC2)c1.Clc1ccc(-n2c(Cl)nc3ccccc32)cc1>>CC(=O)Nc1cccc(C2CCN(CCCNc3nc4ccccc4n3-c3ccc(Cl)cc3)CC2)c1",
        "output": "544"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(C)c1ncnn1-c1nc2c(s1)CCOc1cc(Br)ccc1-2.CC1(C)OB(c2cn[nH]c2)OC1(C)C.CCOC(C)=O.O.O=C([O-])[O-].[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)c1ncnn1-c1nc2c(s1)CCOc1cc(-c3cn[nH]c3)ccc1-2",
        "output": "971"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.N#CC1(c2ccc(OCC3CN(C4CCC4)C3)cc2)CCOCC1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>NCC1(c2ccc(OCC3CN(C4CCC4)C3)cc2)CCOCC1",
        "output": "246"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COCCOCCOC.Cc1cc(C)nc(N2CCNCC2)c1.Cc1cc(Cl)ccc1[N+](=O)[O-].Cl.O=C([O-])[O-].[K+].[K+]>>Cc1cc(C)nc(N2CCN(c3ccc([N+](=O)[O-])c(C)c3)CC2)c1",
        "output": "105"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(C)=O.CNCCO.ClCCCl.O=Cc1ccc(-c2ccc(C(CC3CCOCC3)c3ccc(S(=O)(=O)C4CC4)cc3)[nH]2)nc1.[Na+]>>CN(CCO)Cc1ccc(-c2ccc(C(CC3CCOCC3)c3ccc(S(=O)(=O)C4CC4)cc3)[nH]2)nc1",
        "output": "757"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1ccc2nc(-c3coc4ccccc34)c(N(C)C(C)C)nc2c1.Cl.O.[Na+].[OH-]>>CC(C)N(C)c1nc2cc(C(=O)O)ccc2nc1-c1coc2ccccc12",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1ccc2cn[nH]c2c1.CN(C)C=O.II.[K+].[OH-]>>CC(C)(C)c1ccc2c(I)n[nH]c2c1",
        "output": "923"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ncnc(Cl)c1C.Nc1ccc(C(F)(F)F)cc1>>Cc1ncnc(Nc2ccc(C(F)(F)F)cc2)c1C",
        "output": "352"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.C[Si](C)(C)C=[N+]=[N-].ClCCl.O=C(O)C(Sc1ccc(Cl)cc1)c1ccc(Cl)cc1>>COC(=O)C(Sc1ccc(Cl)cc1)c1ccc(Cl)cc1",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1.CCCOC(=O)Cl.CN(C)c1ccncc1.c1ccncc1>>CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1",
        "output": "102"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[Si](OC1CCC(CO)CC1)(c1ccccc1)c1ccccc1.CCN(CC)CC.CS(C)=O>>CC(C)(C)[Si](OC1CCC(C=O)CC1)(c1ccccc1)c1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Cc1ccc(Cl)c(S(=O)(=O)Cl)c1.CC(=O)Cc1ccc(Cl)c(S(N)(=O)=O)c1.N.NCCO>>CC(=O)Cc1ccc(Cl)c(S(=O)(=O)NCCO)c1",
        "output": "43"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(C)=O.CCOc1cc(Br)cc(C(=O)OC)c1.O.O.[BH4-].[Cl-].[Li+].[Na+]>>CCOc1cc(Br)cc(CO)c1",
        "output": "444"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)c1ccc(O)cc1.OC(CCl)CCCl>>CC(C)(C)c1ccc(OCC(O)CCCl)cc1",
        "output": "74"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)CCCCCNC(=O)OCc1ccccc1.CCO.[Pd]>>CC(C)(C)OC(=O)CCCCCN",
        "output": "574"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(N)COc1ccccc1.CCN(C(C)C)C(C)C.OC[C@H]1O[C@@H](n2cnc3c(Cl)ncnc32)[C@H](O)[C@@H]1O>>CC(COc1ccccc1)Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O",
        "output": "145"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Nc1ccc(C(F)(F)F)cn1.O=C(Cl)c1ccc(F)c([N+](=O)[O-])c1>>O=C(Nc1ccc(C(F)(F)F)cn1)c1ccc(F)c([N+](=O)[O-])c1",
        "output": "463"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)CC1CC(C)(C)c2cc(NC(=O)c3ccc(C=NN)cc3)ccc2O1.Cl.[Na+].[OH-]>>CC1(C)CC(CC(=O)O)Oc2ccc(NC(=O)c3ccc(C=NN)cc3)cc21",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)Nc1ccc(Nc2cc(Cl)ncn2)cc1.CC(C)(C)OC(N)=O.Cl>>Nc1ccc(Nc2cc(Cl)ncn2)cc1",
        "output": "782"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(=O)CCl.CO.Cn1nnc2c(C#N)nc(-c3ccc(OCCC4CCNCC4)c(C(F)(F)F)c3)cc21.O=C(O)C(F)(F)F>>CN(C)C(=O)CN1CCC(CCOc2ccc(-c3cc4c(nnn4C)c(C#N)n3)cc2C(F)(F)F)CC1",
        "output": "340"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCOc1ccc(C=O)cc1O.CO.COc1cc(OC)cc(C(C)=O)c1.[Na+].[OH-]>>CCCOc1ccc(/C=C/C(=O)c2cc(OC)cc(OC)c2)cc1O",
        "output": "656"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)NCC(=O)O.ClCCl.Nc1ccccc1>>CC(C)(C)OC(=O)NCC(=O)Nc1ccccc1",
        "output": "365"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CN.COC(=O)c1ccc(N(C)c2cc3c(cn2)ncn3C)c(C)c1>>CNC(=O)c1ccc(N(C)c2cc3c(cn2)ncn3C)c(C)c1",
        "output": "338"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)n1ccc(-c2ccc(-c3nc4cc(I)ccc4o3)cc2)n1.ClC(Cl)Cl.O=C(O)C(F)(F)F>>Ic1ccc2oc(-c3ccc(-c4cc[nH]n4)cc3)nc2c1",
        "output": "896"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCOC(C)=O.CSc1ccc(C(Cc2cccc(-c3cc(C(C)(C)S(C)(=O)=O)cc4cccnc34)c2)C(O)c2ccccc2)cc1.ClCCl.O=C([O-])O.[Na+]>>CSc1ccc(C(Cc2cccc(-c3cc(C(C)(C)S(C)(=O)=O)cc4cccnc34)c2)C(=O)c2ccccc2)cc1",
        "output": "32"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.C[Si](C)(C)C#Cc1ccc(OCC2CC2)cn1.[F-]>>C#Cc1ccc(OCC2CC2)cn1",
        "output": "337"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC[N+](CC)(CC)Cc1ccccc1.CN(C)CCCl.Cc1ccccc1.Cl.O.OCc1nc2c(s1)-c1ccccc1Sc1ccc(F)cc1-2.[Cl-].[Na+].[OH-]>>CN(C)CCOCc1nc2c(s1)-c1ccccc1Sc1ccc(F)cc1-2",
        "output": "308"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CCc1ccc(C=O)cc1.CC(=O)c1ccc(OCC=C(C)C)cc1OCC(=O)O.CCO.[K+].[OH-]>>C=CCc1ccc(C=CC(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1",
        "output": "295"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CN(c1cnc(OCc2ccccc2)c(-c2ccccc2)c1)c1ccnc(NC2CCN(C(=O)OC(C)(C)C)CC2)n1.Cl>>CN(c1cnc(OCc2ccccc2)c(-c2ccccc2)c1)c1ccnc(NC2CCNCC2)n1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCn1cc(C2CCN(C)CC2)c2cc(OC)cc(C)c21.Cl.c1ccncc1>>CCCn1cc(C2CCN(C)CC2)c2cc(O)cc(C)c21",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)Cc1csc(NC(=O)C(CC2CCCC2)c2ccc(Cl)c(Cl)c2)n1.[BH4-].[Na+]>>O=C(Nc1nc(CCO)cs1)C(CC1CCCC1)c1ccc(Cl)c(Cl)c1",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(NCc2ccc([N+](=O)[O-])c(F)c2)CC1.Cl.ClCCl>>O=[N+]([O-])c1ccc(CNC2CCNCC2)cc1F",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.COc1ccc(Nc2ncc(CN3CCNCC3)cc2-c2nc(C)nc3[nH]cnc23)cn1.ClCCl.O.[Cl-].[NH4+]>>COc1ccc(Nc2ncc(CN3CCN(C(C)=O)CC3)cc2-c2nc(C)nc3[nH]cnc23)cn1",
        "output": "369"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CI.O=C(CC(c1ccc(Br)cc1)c1ccccc1Cl)c1ccc(=O)[nH]c1.O=C([O-])[O-].[K+].[K+]>>Cn1cc(C(=O)CC(c2ccc(Br)cc2)c2ccccc2Cl)ccc1=O",
        "output": "191"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cl.ClCCl.O=C(OCC1CCNCC1)[C@](O)(c1ccccc1)c1cccc(O)c1.O=Cc1ccccc1.[Na+]>>O=C(OCC1CCN(Cc2ccccc2)CC1)[C@](O)(c1ccccc1)c1cccc(O)c1",
        "output": "567"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NCc1csc(C2CC2)n1.O=C(O)c1cnc(OCC(F)(F)F)c(C2CCCC2)c1>>O=C(NCc1csc(C2CC2)n1)c1cnc(OCC(F)(F)F)c(C2CCCC2)c1",
        "output": "674"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@@H]5CC[C@H](CC4=O)N5)cn3)nc2n1C1CCCC1>>CC(C)N1[C@@H]2CC[C@H]1CN(c1ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc1)C(=O)C2",
        "output": "187"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)c1cc(CN2CCNCC2)cc(C(C)(C)C)c1.CC(C)=O.CCCCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.CN(C)C=O.COCOc1ccc(C2(C)COc3cc(OCOC)ccc3C2c2ccc(OCCCl)cc2)cc1.O=C([O-])[O-].[I-].[K+].[K+]>>COCOc1ccc(C2(C)COc3cc(OCOC)ccc3C2c2ccc(OCCN3CCN(Cc4cc(C(C)(C)C)cc(C(C)(C)C)c4)CC3)cc2)cc1",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.CC#N.CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COCCCN(CCCc1ccc(Br)cc1)C(=O)OC(C)(C)C.[K+].[Pd+2]>>COCCCN(CCCc1ccc(B2OC(C)(C)C(C)(C)O2)cc1)C(=O)OC(C)(C)C",
        "output": "942"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)CC(C)C.Cc1nc2c(C)cccn2c(=O)c1CCBr.Cl.Fc1ccc2c(C3CCNCC3)noc2c1.O.O=C([O-])[O-].[I-].[K+].[Na+].[Na+]>>Cc1nc2c(C)cccn2c(=O)c1CCN1CCC(c2noc3cc(F)ccc23)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCS.COc1cc2c(cc1C(C)C)CCCC2=O.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(C)c1cc2c(cc1O)C(=O)CCC2",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C[Si](C)(C)[N-][Si](C)(C)C.FC(F)(F)c1cc(I)ccc1CBr.O=C1c2ccccc2C(=O)N1c1cc[nH]n1.[Li+]>>O=C1c2ccccc2C(=O)N1c1ccn(Cc2ccc(I)cc2C(F)(F)F)n1",
        "output": "635"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cc(CC)sc1Nc1ccc(Br)cc1[N+](=O)[O-].O.[Cl-].[NH4+].[Zn]>>CCOC(=O)c1cc(CC)sc1Nc1ccc(Br)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C/C=C\\c1cc(C(=O)OC)ccc1N1CCN(CCOCc2ccccc2)CC1.CO.Cl.[Na+].[OH-]>>C/C=C\\c1cc(C(=O)O)ccc1N1CCN(CCOCc2ccccc2)CC1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(C)=O.CCN.N#Cc1cnn(-c2ccc(C(F)(F)F)cc2Cl)c1NCC(=O)Cl>>CCNC(=O)CNc1c(C#N)cnn1-c1ccc(C(F)(F)F)cc1Cl",
        "output": "45"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.OCc1cc2ccc(Cl)cc2[nH]1.[Mn+4].[O-2].[O-2]>>O=Cc1cc2ccc(Cl)cc2[nH]1",
        "output": "263"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.CCO.Nc1cc(F)cc(Cl)c1>>CC(=O)Nc1cc(F)cc(Cl)c1",
        "output": "6"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1cc2c(cc1Br)C(=O)CC2.Cl.[Na+].[OH-]>>Nc1cc2c(cc1Br)C(=O)CC2",
        "output": "66"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.N#Cc1ccc2cc(Cc3cc(C(=O)O)ccn3)ccc2n1.NCc1ccc2c(N)nccc2c1.O.On1nnc2ccccc21>>N#Cc1ccc2cc(Cc3cc(C(=O)NCc4ccc5c(N)nccc5c4)ccn3)ccc2n1",
        "output": "753"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.C[Si](C)(C)C#Cc1cnc(N)c(C#N)n1.O=C([O-])[O-].[K+].[K+]>>C#Cc1cnc(N)c(C#N)n1",
        "output": "337"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CC(C(=O)O)C1.CC(C)COC(=O)Cl.CN1CCCC1=O.N.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N1CC(C(N)=O)C1",
        "output": "313"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(F)cc2C(F)(F)F)CC1.CC(Cl)Cl.ClCCl.O=C(O)C(F)(F)F>>Fc1ccc(N2CCNCC2)c(C(F)(F)F)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(C(C)C)C(C)C.CN(C)c1ccncc1.Cc1cc2c(cc1C(F)(F)F)NCCCC2=O.ClCCl>>Cc1cc2c(cc1C(F)(F)F)N(C(=O)OC(C)(C)C)CCCC2=O",
        "output": "827"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)Cl.Nc1ccc(N2CCN(c3ccncc3)CC2)cc1.c1ccncc1>>CS(=O)(=O)Nc1ccc(N2CCN(c3ccncc3)CC2)cc1",
        "output": "194"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC[C@H](N[S@@](=O)C(C)(C)C)c1ccc(Cl)c(Oc2cccc(C=O)c2)c1F.CO.[BH4-].[Na+]>>CC[C@H](N[S@@](=O)C(C)(C)C)c1ccc(Cl)c(Oc2cccc(CO)c2)c1F",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.COC(=O)Cl.COc1cc(N2CCNCC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1.ClCCl>>COC(=O)N1CCN(c2ccc(Nc3ncc(Cl)c(-c4cnc5ccccn45)n3)c(OC)c2)CC1",
        "output": "219"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCOC(C)=O.CO.O=C(N[C@H]1CCCC[C@@H]1O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2n1.[Pd]>>O=C(N[C@H]1CCCC[C@@H]1O)c1cc(Cc2cccnc2)c2ccccc2n1",
        "output": "40"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC1(c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cccc(F)c23)CCC(CO[Si](C)(C)C(C)(C)C)CC1.CCCC[N+](CCCC)(CCCC)CCCC.O.[F-]>>CC1(c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cccc(F)c23)CCC(CO)CC1",
        "output": "708"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccccc1N=C=O.ClCCl.Clc1ccc2c(N3CCNCC3)ccnc2c1>>Cc1ccccc1NC(=O)N1CCN(c2ccnc3cc(Cl)ccc23)CC1",
        "output": "323"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(-c2nc3cc(Cl)ccc3o2)cc1N.O=C(O)c1ccc2c(c1)C(=O)OC2=O>>COc1ccc(-c2nc3cc(Cl)ccc3o2)cc1N1C(=O)c2ccc(C(=O)O)cc2C1=O",
        "output": "475"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCOP(=O)(C#N)OCC.Cl.ClCCl.O=C(O)c1ccc(C(=O)c2cccs2)cc1.[Na+].[OH-].c1cc2c(o1)CNCC2>>O=C(c1ccc(C(=O)N2CCc3ccoc3C2)cc1)c1cccs1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCOc1nc(N)c2nc(OC)n(CCCC3CCCCN3)c2n1.CCCCOc1nc(N)c2nc(OC)n(CCCCCCC3CCN(C(=O)OCc4ccccc4)CC3)c2n1>>CCCCOc1nc(N)c2nc(OC)n(CCCCCCC3CCNCC3)c2n1",
        "output": "428"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1CCN(C=Nc2ccc(CN3CCN(S(=O)(=O)c4cc5ccc(Cl)cc5s4)CC3=O)cc2)CC1.CO.O.[Li+].[OH-]>>O=C(O)C1CCN(C=Nc2ccc(CN3CCN(S(=O)(=O)c4cc5ccc(Cl)cc5s4)CC3=O)cc2)CC1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CO.COc1cc(C(C)=O)ccc1OCCCCl.ClCCl.O=C([O-])O.O=C=O.[Na+]>>CC(=O)c1ccc(OCCCCl)c(O)c1",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1ccc(NC(=O)c2ccc3c(c2)C(c2ccc(C)cc2)=CCC3(C)C)cc1F.[Na+].[OH-]>>Cc1ccc(C2=CCC(C)(C)c3ccc(C(=O)Nc4ccc(C(=O)O)c(F)c4)cc32)cc1",
        "output": "5"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CN[C@H]1CCCC[C@@H]1NC.Cc1cc[nH]n1.Cc1ccccc1.O=C([O-])[O-].O=C1OC2(CCN(C(=O)C3(c4ccc(Br)cc4)CC3)C2)c2ccncc21.[Cu]I.[K+].[K+]>>Cc1ccn(-c2ccc(C3(C(=O)N4CCC5(C4)OC(=O)c4cnccc45)CC3)cc2)n1",
        "output": "919"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNC1.COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCBr>>COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCN1CCCC1",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "O=S(Cl)Cl.OCc1ccc(OCc2ccccc2)cc1OCc1ccccc1.c1ccccc1>>ClCc1ccc(OCc2ccccc2)cc1OCc1ccccc1",
        "output": "81"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1cccc(O)c1C.O.O=[N+]([O-])c1ccc(Cl)nc1.[H-].[Na+]>>COc1cccc(Oc2ccc([N+](=O)[O-])cn2)c1C",
        "output": "516"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCO.N#Cc1cc([N+](=O)[O-])cnc1SCc1ccccc1.[Fe]>>N#Cc1cc(N)cnc1SCc1ccccc1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CN(C)C=O.COc1ccc(CCl)cc1.Cl.O=C(c1ccc(-n2cc(-c3n[nH]c4ccc(Br)cc34)nn2)cc1)N1CCOCC1.[K+].[OH-]>>COc1ccc(Cn2nc(-c3cn(-c4ccc(C(=O)N5CCOCC5)cc4)nn3)c3cc(Br)ccc32)cc1",
        "output": "842"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCCCCCCCCCCCCNC(=O)OCC(CC#N)CN=[N+]=[N-].CCCCCCCCCCCCCCCCCCNC(=O)OCC(CN)CC(C)OC(=O)c1ccccc1.CO.[Pd]>>CCCCCCCCCCCCCCCCCCNC(=O)OCC(CN)CC#N",
        "output": "89"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.CCOC(=O)Cc1ccc(N)cc1.O=C([O-])[O-].O=CO.[Na+].[Na+]>>CCOC(=O)Cc1ccc(NC=O)cc1",
        "output": "27"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.O=c1cc(NCc2ccccc2)c2cncnc2n1OCc1ccccc1.[C].[H][H].[Pd]>>O=c1cc(NCc2ccccc2)c2cncnc2n1O",
        "output": "630"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)C(C)(C)c1ccc(N)cc1.O=C1CCC(=O)N1Br>>CCOC(=O)C(C)(C)c1ccc(N)c(Br)c1",
        "output": "4"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C=C(C)C(=O)Cl.O.OCCCl.c1ccncc1>>C=C(C)C(=O)OCCCl",
        "output": "320"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCc1cc(C(=O)O)no1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.ClC(Cl)Cl.NCC1CCOC1.On1nnc2ccccc21>>CCCCCc1cc(C(=O)NCC2CCOC2)no1",
        "output": "696"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.Cn1c(=O)[nH]c2ccc(OCCOCc3ccccc3)cc21.[Pd]>>Cn1c(=O)[nH]c2ccc(OCCO)cc21",
        "output": "178"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COCc1cc2c(C(=O)O)ccc(OC)c2o1.Cn1ncc(Cl)c1N>>COCc1cc2c(C(=O)Nc3c(Cl)cnn3C)ccc(OC)c2o1",
        "output": "917"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.COC(=O)N1CC(c2nc(-c3ccc(C)c(N)c3)no2)C1.Cc1ccc2ncc(C(=O)O)n2c1.ClCCl.O=C(Cl)C(=O)Cl.c1ccncc1>>COC(=O)N1CC(c2nc(-c3ccc(C)c(NC(=O)c4cnc5ccc(C)cn45)c3)no2)C1",
        "output": "889"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1cc(Cl)c(S(C)(=O)=O)c(Cl)c1.CC[BH-](CC)CC.O.[Li+]>>CS(=O)(=O)c1c(Cl)cc(CO)cc1Cl",
        "output": "311"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1C=C2C(=C(C3=CCN(C4CCC(=CC(=O)OC(C)(C)C)CC4)CC3)C1)NN=C1C=Cc3cc(F)cc2c31.ClCCl.O=C(O)C(F)(F)F>>CN1C=C2C(=C(C3=CCN(C4CCC(=CC(=O)O)CC4)CC3)C1)NN=C1C=Cc3cc(F)cc2c31",
        "output": "158"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)[C@@H]1[C@@H]2[C@H](CN1S(=O)(=O)c1ccc(F)cc1)C2(F)F.O.O.[Li+].[OH-]>>O=C(O)[C@@H]1[C@@H]2[C@H](CN1S(=O)(=O)c1ccc(F)cc1)C2(F)F",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "NCCCCCC(=O)O.O.O=C(Cl)c1ccc(Br)cc1.O=C([O-])[O-].[Na+].[Na+]>>O=C(O)CCCCCNC(=O)c1ccc(Br)cc1",
        "output": "271"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "N#Cc1ccc(CCO)cc1.O.O=C1CCC(=O)N1Br.O=S(=O)(O)O.[Al].[Na+].[OH-]>>N#Cc1ccc(CCO)c(Br)c1",
        "output": "4"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.COC(=O)c1cnc(Cl)nc1C(F)(F)F.Nc1cccc(Cl)c1>>COC(=O)c1cnc(Nc2cccc(Cl)c2)nc1C(F)(F)F",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "NNc1cc(=O)nc[nH]1.NNc1cc(O)ncn1.O=C1CCCCCC1>>Oc1cc(NN=C2CCCCCC2)ncn1",
        "output": "285"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc(F)c(C=O)cc1OC.O=S(=O)(O)O>>COc1cc(F)c(C=O)cc1O",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "B1C2CCCC1CCC2.C1CCOC1.C=CCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc21.O.OO.[Na+].[OH-]>>O=C(NCC(F)(F)F)C1(CCCO)c2ccccc2-c2ccccc21",
        "output": "465"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCOCC.COCC1(NC(=O)OCc2ccccc2)CCN(C(=O)OC(C)(C)C)CC1.Cl>>COCC1(NC(=O)OCc2ccccc2)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.CCCC(=C(c1ccc(OC(=O)C(C)(C)C)cc1)c1ccc(OC(=O)C(C)(C)C)cc1)c1cccc(O)c1.Cl.ClCCN1CCCCC1.O.O=C([O-])[O-].[K+].[K+]>>CCCC(=C(c1ccc(OC(=O)C(C)(C)C)cc1)c1ccc(OC(=O)C(C)(C)C)cc1)c1cccc(OCCN2CCCCC2)c1",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNCC1.CC#N.CCN(C(C)C)C(C)C.O=c1oc2cccnc2n1CCBr>>O=c1oc2cccnc2n1CCN1CCCCC1",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CN2CCN1CC2.COC(=O)[C@@H]1C[C@H](O)CN1C(=O)OC(C)(C)C.Cc1ccccc1.O=S(=O)(Cl)c1ccc(Br)cc1>>COC(=O)[C@@H]1C[C@H](OS(=O)(=O)c2ccc(Br)cc2)CN1C(=O)OC(C)(C)C",
        "output": "197"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.ClCCl.O=C(O)c1c(Cl)cncc1Cl.O=S(Cl)Cl>>O=C(Cl)c1c(Cl)cncc1Cl",
        "output": "3"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Fc1ccc(OCc2cn3cc(Br)cnc3n2)cc1.OB(O)c1ccccc1>>Fc1ccc(OCc2cn3cc(-c4ccccc4)cnc3n2)cc1",
        "output": "871"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCC.ClCCl.II.Nc1ccccc1F.O.O=C([O-])O.O=S([O-])O.[Na+]>>Nc1ccc(I)cc1F",
        "output": "372"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#CCCCO.CCNCC.Cc1ccccc1I>>Cc1ccccc1C#CCCCO",
        "output": "664"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cc(Nc2ncnc3cccc(O[C@H](C)CNC(=O)CO)c23)ccc1O.ClCc1ccccn1>>Cc1cc(Nc2ncnc3cccc(O[C@H](C)CNC(=O)CO)c23)ccc1OCc1ccccn1",
        "output": "616"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCC(Cc1cc2cc(OCCCNc3ccccn3)ccc2[nH]1)C(=O)OC.CO.O.[Na+].[OH-]>>CCCC(Cc1cc2cc(OCCCNc3ccccn3)ccc2[nH]1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CO.Cc1c(NC(=O)OCc2ccccc2)cccc1C(C[N+](=O)[O-])c1c[nH]c2cc(Br)ccc12.[Cl-].[NH4+].[Zn]>>Cc1c(NC(=O)OCc2ccccc2)cccc1C(CN)c1c[nH]c2cc(Br)ccc12",
        "output": "226"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CCCN.Clc1ccn2ncc(Br)c2n1>>CCN(CC)CCCNc1ccn2ncc(Br)c2n1",
        "output": "166"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCCN.COc1ccc(N2CCOCC2)c2sc(NC(=O)c3ccc(Cl)nc3)nc12.O=C([O-])[O-].[Cs+].[Cs+]>>COCCNc1ccc(C(=O)Nc2nc3c(OC)ccc(N4CCOCC4)c3s2)cn1",
        "output": "70"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#CCNC(=O)c1cccc(F)c1Nc1nc(Cl)ncc1Cl.CC1(C)CC(NC(=O)C(F)(F)F)C(=O)Nc2cc(N)ccc21>>C#CCNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)NC(=O)C(NC(=O)C(F)(F)F)CC3(C)C)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.Cl[Pd]Cl.NC(=O)c1ccc2cncc(Br)c2n1.O.O=C([O-])[O-].OB(O)c1ccc(-n2cccn2)cc1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>NC(=O)c1ccc2cncc(-c3ccc(-n4cccn4)cc3)c2n1",
        "output": "871"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(N)CC(=O)O.CCO.O=C([O-])[O-].O=[N+]([O-])c1ccccc1F.[K+].[K+]>>CC(C)(CC(=O)O)Nc1ccccc1[N+](=O)[O-]",
        "output": "572"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.CNOC.Cl.Cl.ClCCl.O=C(O)C1CCN(C(=O)OCc2ccccc2)CC1>>CON(C)C(=O)C1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "54"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)C1(CC(=O)OC(C)(C)C)Cc2ccccc2C1.Cl.O.[Na+].[OH-]>>CC(C)(C)OC(=O)CC1(C(=O)O)Cc2ccccc2C1",
        "output": "281"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(F)c(OCC(F)(F)F)c1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>Fc1ccc(CBr)cc1OCC(F)(F)F",
        "output": "29"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.NC1CCN(Cc2ccccc2)CC1.O=C(O)CCc1nc(-c2ccccn2)no1.O=C(n1ccnc1)n1ccnc1>>O=C(CCc1nc(-c2ccccn2)no1)NC1CCN(Cc2ccccc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCOC(=O)N1CCC(N)CC1.CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.ClCCl.O>>CCCCOC(=O)N1CCC(NS(C)(=O)=O)CC1",
        "output": "493"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.Cc1ccn2nc([C@H](C)N)n(-c3ccccc3)c(=O)c12.Cc1nc(Cl)c2ccsc2n1>>Cc1nc(N[C@@H](C)c2nn3ccc(C)c3c(=O)n2-c2ccccc2)c2ccsc2n1",
        "output": "723"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.Nc1nccs1.O=C(O)C(CC1CCCC1)c1ccc(-c2ccccc2)cc1>>O=C(Nc1nccs1)C(CC1CCCC1)c1ccc(-c2ccccc2)cc1",
        "output": "681"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)CCc1nc2ccccc2n1Cc1ccc(NC)c([N+](=O)[O-])c1.CO.ClCCl.[Pd]>>CCOC(=O)CCc1nc2ccccc2n1Cc1ccc(NC)c(N)c1",
        "output": "71"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)C1.CCOCC.Cl>>NC1CCN(c2nccnc2C2CN(c3ccc4ccccc4n3)C2)C1",
        "output": "538"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O.O=C(O)c1ccn(Cc2cccc(Cl)c2)c(=O)c1>>O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccn(Cc2cccc(Cl)c2)c(=O)c1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOc1cc(C(CC(=O)O)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC.Cl.NO.O=C(n1ccnc1)n1ccnc1>>CCOc1cc(C(CC(=O)NO)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC",
        "output": "480"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1c(Cl)c(C(=O)N2CCC(c3ccc(F)cc3)CC2)cn(C)c1=O.N#Cc1ccc(N)cc1Cl>>Cc1c(Nc2ccc(C#N)c(Cl)c2)c(C(=O)N2CCC(c3ccc(F)cc3)CC2)cn(C)c1=O",
        "output": "957"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(C(=O)c2cc(C(=O)c3ccc(OC)cc3)cc([N+](=O)[O-])c2)cc1.Cl.O.[Br-].[K+].c1ccncc1>>O=C(c1ccc(O)cc1)c1cc(C(=O)c2ccc(O)cc2)cc([N+](=O)[O-])c1",
        "output": "20"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrC(Br)(Br)Br.CC(=O)OCC(CCO)COC(C)=O.CN(C)C=O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(=O)OCC(CCBr)COC(C)=O",
        "output": "378"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)CBr.CCOC(C)=O.CN(C)C=O.COc1cc(O)ccc1C=O.O=C([O-])[O-].[K+].[K+]>>COc1cc(OCC(=O)OC(C)(C)C)ccc1C=O",
        "output": "393"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CC(=O)N(C)C)c1=O.C[C@H](N)CO>>C[C@@H](CO)NC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CC(=O)N(C)C)c1=O",
        "output": "498"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)o1.O=Cc1ccc(O)c(Cl)c1Cl>>O=C(C=Cc1ccc(O)c(Cl)c1Cl)c1ccc(-c2ccc(C(F)(F)F)cc2)o1",
        "output": "295"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.Cc1sc(NC(=O)c2ccc(Cl)nc2)nc1-c1ccccc1.Cl.FC(F)(F)c1cccc(C2CCNCC2)c1>>Cc1sc(NC(=O)c2ccc(N3CCC(c4cccc(C(F)(F)F)c4)CC3)nc2)nc1-c1ccccc1",
        "output": "220"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CO[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(OCCO)cc3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CO[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(OCC=O)cc3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCCc1ccc(C(O)CC(CO)(CO)NC(C)=O)cc1.CO.O.[Li+].[OH-]>>CCCCCCCCc1ccc(C(O)CC(N)(CO)CO)cc1",
        "output": "412"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCCc1cc(F)ccc1C=O.CO.NC1CC1.[BH4-].[Na+]>>C=CCCc1cc(F)ccc1CNC1CC1",
        "output": "468"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3c(c2)c(C2CCC2)cn3S(=O)(=O)c2ccccc2)c1F.CCOC(C)=O.CO.O=C([O-])[O-].[K+].[K+]>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]cc(C4CCC4)c3c2)c1F",
        "output": "831"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(N)c1ccccc1-c1ccc(Cl)cc1F.CCN(CC)CC.COc1cccc(S(=O)(=O)Cl)c1>>COc1cccc(S(=O)(=O)NC(C)c2ccccc2-c2ccc(Cl)cc2F)c1",
        "output": "530"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=C(C)CC(NC(=O)OC(C)(C)C)C(=O)OCC.CC(C)=O.[Li+].[OH-]>>C=C(C)CC(NC(=O)OC(C)(C)C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1ccc2c(c1)Nc1c(cnn1C)CN2C(=O)C1CCC(CN)CC1.ClCCl>>Cc1ccc2c(c1)Nc1c(cnn1C)CN2C(=O)C1CCC(CNS(C)(=O)=O)CC1",
        "output": "493"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Nc1cccc(CC2CCC(=O)C2)n1.[BH4-].[Na+]>>CC(C)(C)OC(=O)Nc1cccc(CC2CCC(O)C2)n1",
        "output": "91"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O=C(N1CCc2ccc([N+](=O)[O-])cc2CC1)C(F)(F)F.[Pd]>>Nc1ccc2c(c1)CCN(C(=O)C(F)(F)F)CC2",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCc1nc2cc(C)n(Cc3ccc(-c4ccccc4-c4nnnn4C(c4ccccc4)(c4ccccc4)c4ccccc4)cc3)n2n1.CCCc1nn2nc(C)cc2[nH]1>>CCCc1nc2cc(C)n(Cc3ccc(-c4ccccc4-c4nnn[nH]4)cc3)n2n1",
        "output": "815"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CC(C)OCCn1c(NC2CCNCC2)nc2ccccc21.CCN(CC)CC.CO.COc1ccc(-n2cnnn2)cc1C(=O)N1CCC(CCOS(C)(=O)=O)(c2ccccc2)C1.ClCCl.I>>COc1ccc(-n2cnnn2)cc1C(=O)N1CCC(CCN2CCC(Nc3nc4ccccc4n3CCOC(C)C)CC2)(c2ccccc2)C1",
        "output": "496"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[C@@H]1C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@@H]1NC(=O)OCc1ccccc1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.C[Si](C)(C)[N-][Si](C)(C)C.Cc1ccccc1.[Br-].[K+]>>C=C(C)[C@@H]1C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@@H]1NC(=O)OCc1ccccc1",
        "output": "601"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CN1CCC(c2c[nH]c3ccc(O)cc23)CC1.O=S(=O)(Cl)c1ccc(I)cc1.[Na+].[OH-]>>CN1CCC(c2c[nH]c3ccc(OS(=O)(=O)c4ccc(I)cc4)cc23)CC1",
        "output": "380"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.O=C(O)C1CN(C(c2ccccc2)c2ccccc2)C1.OCC1CN(C(c2ccccc2)c2ccccc2)C1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CS(=O)(=O)OCC1CN(C(c2ccccc2)c2ccccc2)C1",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.c1ccc(C2CCNCC2)cc1.c1ccc2c(OCC3CO3)cccc2c1>>OC(COc1cccc2ccccc12)CN1CCC(c2ccccc2)CC1",
        "output": "76"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(c1ccc2nc(N)cn2n1)c1nnc2ccc(Br)cn12.CCN(C(C)C)C(C)C.ClCCl.O=C(Cl)C1CC1.O=C(O)C(F)(F)F>>CC(c1ccc2nc(NC(=O)C3CC3)cn2n1)c1nnc2ccc(Br)cn12",
        "output": "399"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C1c2ccccc2C(=O)N1CCBr.c1ccc(C(=C2CCNCC2)c2ccccc2)cc1>>O=C1c2ccccc2C(=O)N1CCN1CCC(=C(c2ccccc2)c2ccccc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cccc2c1OC(CN=[N+]=[N-])C2.COc1cccc2c1OC(COS(=O)(=O)c1ccc(C)cc1)C2.[N-]=[N+]=[N-].[N-]=[N+]=[N-].[Na+].[Pd]>>COc1cccc2c1OC(CN)C2",
        "output": "89"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.NC(=O)n1ccc(-c2ccc(Oc3ccc([N+](=O)[O-])cc3)cc2)n1.[H][H].[Pd]>>NC(=O)n1ccc(-c2ccc(Oc3ccc(N)cc3)cc2)n1",
        "output": "335"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1nc2ccccc2cc1NC(=O)Oc1ccccc1.c1ccc2c(N3CCNCC3)cccc2c1>>COc1nc2ccccc2cc1NC(=O)N1CCN(c2cccc3ccccc23)CC1",
        "output": "525"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(F)c(B(O)O)c1.NC1=NC(c2ccncc2)(c2cccc(Br)c2)C2=NCC(F)(F)CN12>>COc1ccc(F)c(-c2cccc(C3(c4ccncc4)N=C(N)N4CC(F)(F)CN=C43)c2)c1",
        "output": "908"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CI.Cc1cc(C(=O)O)ccc1[N+](=O)[O-].O=C([O-])O.[Na+]>>COC(=O)c1ccc([N+](=O)[O-])c(C)c1",
        "output": "415"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)CCN.O=C(O)c1ccc(S(=O)(=O)Cc2c(O[C@H](Cn3ccnc3)c3ccccc3)ccc3c2CCCC3=O)cc1>>CN(C)CCNC(=O)c1ccc(S(=O)(=O)Cc2c(O[C@H](Cn3ccnc3)c3ccccc3)ccc3c2CCCC3=O)cc1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.O=C1CCCN1CC(O)CCl>>O=C(CCl)CN1CCCC1=O",
        "output": "87"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)C(C)C(C)NC1CCCC1.CCOCC.O.O=C([O-])O.O=[N+]([O-])c1cnc(Cl)nc1Cl.[K+]>>CCOC(=O)C(C)C(C)N(c1nc(Cl)ncc1[N+](=O)[O-])C1CCCC1",
        "output": "296"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCCCN.CCN=C=NCCCN(C)C.CCc1cc(-c2n[nH]c(C(=O)O)c2-c2ccc(OC)cc2)c(O)cc1O.CN1CCOCC1.Cl.ClCCl.On1nnc2ccccc21>>CCc1cc(-c2n[nH]c(C(=O)NCCCNC(=O)OC(C)(C)C)c2-c2ccc(OC)cc2)c(O)cc1O",
        "output": "816"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc(C(=O)c2ccc(Cl)c(S(N)(=O)=O)c2)cc1O[Si](C)(C)C(C)(C)C.[F-]>>COc1ccc(C(=O)c2ccc(Cl)c(S(N)(=O)=O)c2)cc1O",
        "output": "754"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(F)cc1.O=S(=O)(O)Cl>>COc1ccc(F)cc1S(=O)(=O)Cl",
        "output": "182"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)c1ccc(F)cc1.COC(OC)N(C)C>>CN(C)/C=C/C(=O)c1ccc(F)cc1",
        "output": "898"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CCC1C=NN=N1.CCN(CC)CC.CN(C)C=O.O=c1cc2ccc(Br)cc2cn1Cc1cc(F)c(O)c(F)c1.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>O=c1cc2ccc(C#CCC3C=NN=N3)cc2cn1Cc1cc(F)c(O)c(F)c1",
        "output": "659"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc2c(Cl)ncnc2cc1O.ClCCl.OCCN1CCN(CCF)CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc2c(Cl)ncnc2cc1OCCN1CCN(CCF)CC1",
        "output": "478"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.COc1cc2c(Cl)ncnc2cc1OCCCN1CCOCC1.C[Si](C)(C)[N-][Si](C)(C)C.Nc1c(Cl)cc(C#CCNC(=O)N2CCOCC2)c2c1OCO2.[Na+]>>COc1cc2c(Nc3c(Cl)cc(C#CCNC(=O)N4CCOCC4)c4c3OCO4)ncnc2cc1OCCCN1CCOCC1",
        "output": "161"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCN1.O=C(O)CCCCC1SCC(C(=O)Nc2nc(-c3ccc(C(=O)NC4CC4)cc3)cs2)N1C(=O)OCc1ccccc1>>O=C(NC1CC1)c1ccc(-c2csc(NC(=O)C3CSC(CCCCC(=O)N4CCOCC4)N3C(=O)OCc3ccccc3)n2)cc1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.Cc1cc(C(=O)Nc2c(F)ccc(O)c2C)c(F)c(-c2cccc(F)c2)c1>>Cc1cc(CNc2c(F)ccc(O)c2C)c(F)c(-c2cccc(F)c2)c1",
        "output": "215"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)O.CC(C)(C)[Si](C)(C)OCCN(C(=O)c1cc2c(s1)-c1ccccc1OCC2)c1ccccc1Cl.CCCC[N+](CCCC)(CCCC)CCCC.O.[F-]>>O=C(c1cc2c(s1)-c1ccccc1OCC2)N(CCO)c1ccccc1Cl",
        "output": "708"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.OC[C@@](O)(CNCc1ccccc1)C(F)(F)F.[H][H].[Pd]>>NC[C@](O)(CO)C(F)(F)F",
        "output": "561"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.O=Cc1ccc(Oc2ccccc2)cc1>>OCc1ccc(Oc2ccccc2)cc1",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)c1cccc(N)c1.Cc1cc(C)c(C(C(=O)O)=C2C(=O)Nc3ccccc32)[nH]1.Cl.Cl>>Cc1cc(C)c(C(C(=O)Nc2cccc(N(C)C)c2)=C2C(=O)Nc3ccccc32)[nH]1",
        "output": "170"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C=CC[C@@H](C)O.C=C[Mg]Cl.Cc1ccc(S(=O)(=O)Cl)cc1.Cl[Cu].[Cl-].[Li+]>>C=CC[C@@H](C)OS(=O)(=O)c1ccc(C)cc1",
        "output": "197"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)CCN.Cc1ccccc1.O=C=Nc1ccccc1>>CN(C)CCNC(=O)Nc1ccccc1",
        "output": "35"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC2(CCNC2=O)CC1.CI.[H-].[Na+]>>CN1CCC2(CCN(C(=O)OC(C)(C)C)CC2)C1=O",
        "output": "83"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.CS(=O)(=O)OCCC1CC1(F)F.C[C@@H](COc1cc2oc(-c3ccc(O)cc3)nc2cn1)NC(=O)OC(C)(C)C.O.O=C([O-])[O-].[K+].[K+]>>C[C@@H](COc1cc2oc(-c3ccc(OCCC4CC4(F)F)cc3)nc2cn1)NC(=O)OC(C)(C)C",
        "output": "702"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CNC.Cc1cc(C(=O)N2CCCCc3ccccc32)ccc1CNC(=O)NCC(=O)O.Cl>>Cc1cc(C(=O)N2CCCCc3ccccc32)ccc1CNC(=O)NCC(=O)N(C)C",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CCC(=O)c1ccc(OC)cc1.CCO.Cl.NO.O.[Na+]>>CCC(=NO)c1ccc(OC)cc1",
        "output": "212"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CO.C[Si](C)(C)C=[N+]=[N-].O=C(O)c1c(F)cccc1[N+](=O)[O-]>>COC(=O)c1c(F)cccc1[N+](=O)[O-]",
        "output": "33"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CCO.CCOC(=O)CCCC(=O)c1ccccc1.Cl.NO.[Na+]>>CCOC(=O)CCC/C(=N\\O)c1ccccc1",
        "output": "212"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Clc1cnc(Cl)c(Cl)c1.[NH4+].[OH-]>>Nc1ncc(Cl)cc1Cl",
        "output": "388"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1nc2c(O)cccc2o1.CCc1noc2cccc(O)c12.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)nc1.[K+].[K+]>>CCc1noc2cccc(Oc3ccc([N+](=O)[O-])cn3)c12",
        "output": "516"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)CCCCCCNc1cc(Cl)c(C)cc1[N+](=O)[O-].[H][H].[Ni]>>CCOC(=O)CCCCCCNc1cc(Cl)c(C)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)COCc2cc(C#N)c(O)nc21.O=P(Cl)(Cl)Cl>>CC1(C)COCc2cc(C#N)c(Cl)nc21",
        "output": "41"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.Cn1nc(-c2ccc(F)cc2)cc1N1CCN(C(=O)OC(C)(C)C)CC1.Cn1nc(-c2ccc(F)cc2)cc1N1CCNCC1.O=C1CCC(=O)N1Br>>Cn1nc(-c2ccc(F)cc2)c(Br)c1N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "620"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)[C@@H](NC(=O)OC(C)(C)C)C(=O)O.CCc1ccc([C@@H]2O[C@H](CO)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)cc1Cc1ccc2c(c1)OCCO2.CN(C)C=O.CN(C)c1ccncc1>>CCc1ccc([C@@H]2O[C@H](COC(=O)[C@H](NC(=O)OC(C)(C)C)C(C)C)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)cc1Cc1ccc2c(c1)OCCO2",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COc1ccnc(-c2ccc(F)c(NC(=S)NC(=O)c3ccccc3)c2)c1.Cl.[Na+].[OH-]>>COc1ccnc(-c2ccc(F)c(NC(N)=S)c2)c1",
        "output": "80"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(O)C(=O)O.Clc1cc(Nc2ncnc3cccc(OC[C@H]4CCCN4)c23)ccc1OCc1ccccn1>>CC(C)(O)C(=O)N1CCC[C@@H]1COc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)c1cccc(OC(C)C2CC2)c1.[BH4-].[Li+]>>CC(Oc1cccc(CO)c1)C1CC1",
        "output": "444"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCN1.Cc1cc(C(=O)O)ccc1-c1cc2nc(-c3cnc(N)nc3)nc(N3CCOCC3)c2s1>>Cc1cc(C(=O)N2CCOCC2)ccc1-c1cc2nc(-c3cnc(N)nc3)nc(N3CCOCC3)c2s1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1sc(N)nc1C.N#Cc1c(Cl)cccc1Oc1ccc(S(=O)(=O)Cl)cc1>>CC(=O)c1sc(NS(=O)(=O)c2ccc(Oc3cccc(Cl)c3C#N)cc2)nc1C",
        "output": "637"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)C#Cc1cccc(Cc2c(-c3ccccc3)n(C(=O)OC(C)(C)C)c3cc(OC)ccc23)n1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)C#Cc1cccc(Cc2c(-c3ccccc3)[nH]c3cc(OC)ccc23)n1",
        "output": "848"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.CN(C)C=O.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C.F[P-](F)(F)(F)(F)F.NCc1ccccc1.O.O=C([O-])O.[Na+]>>COc1cc(C(=O)NCc2ccccc2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "753"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)Cn1ccnc1CCC(=O)N1CCC(N(C)C)CC1.Cl.[Na+].[OH-]>>CN(C)C1CCN(C(=O)CCc2nccn2CC(=O)O)CC1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(O)Cn1ccc(N)n1.O=C(O)C(CC1CCCC1)n1ncc(Oc2ccccc2N2CCOCC2)cc1=O>>CC(C)(O)Cn1ccc(NC(=O)C(CC2CCCC2)n2ncc(Oc3ccccc3N3CCOCC3)cc2=O)n1",
        "output": "795"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1cc(F)cc(F)c1.Oc1cccnc1.[Cl-].[K+].[K+].[NH4+]>>O=[N+]([O-])c1cc(F)cc(Oc2cccnc2)c1",
        "output": "845"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.NC(=O)COc1ccc(C=O)cc1Cl.[BH4-].[Na+]>>NC(=O)COc1ccc(CO)cc1Cl",
        "output": "356"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrP(Br)Br.ClCCl.O=C([O-])O.OCc1c(Br)cccc1OC(F)(F)F.[Na+]>>FC(F)(F)Oc1cccc(Br)c1CBr",
        "output": "300"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.CCOC(C)=O.Nc1cc([N+](=O)[O-])c(CCO)c2ccccc12.c1ccncc1>>CC(=O)OCCc1c([N+](=O)[O-])cc(N)c2ccccc12",
        "output": "254"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(-c2nnc(Cl)cc2-c2ccccc2)cc1.Oc1cccc(F)c1F>>COc1ccc(-c2nnc(Oc3cccc(F)c3F)cc2-c2ccccc2)cc1",
        "output": "603"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.ClCCl.NN.O.O=C1c2ccccc2C(=O)N1OC[C@H]1COCCO1>>NOC[C@H]1COCCO1",
        "output": "452"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCNc1cc(C(=O)OC)cc(C(F)(F)F)c1.CCO.[Na+].[OH-]>>CCNc1cc(C(=O)O)cc(C(F)(F)F)c1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=Cc1ccc(OC)cc1CO[Si](C)(C)C(C)(C)C.CCOC(C)=O.[H][H]>>CCc1ccc(OC)cc1CO[Si](C)(C)C(C)(C)C",
        "output": "555"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CC2(CCN(c3ccc(C(=O)O)cn3)CC2)C1.CCOC(C)=O.CN(C)C=O.ClCCCl.Nc1ccccc1N.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CC2(CCN(c3ccc(C(=O)Nc4ccccc4N)cn3)CC2)C1",
        "output": "739"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)C(=N)NO.O=C(O)C1CC(c2cccc(C(F)(F)F)c2)CN(C(=O)N2CCOCC2)C1>>CC(C)(C)c1noc(C2CC(c3cccc(C(F)(F)F)c3)CN(C(=O)N3CCOCC3)C2)n1",
        "output": "924"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.C[O-].Cc1nc(Cl)nc(Cl)c1CN(C)[C@H]1CCCc2ccccc21.[Na+]>>COc1nc(Cl)nc(C)c1CN(C)[C@H]1CCCc2ccccc21",
        "output": "461"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(C)=O.NC(=O)C1CCNCC1.O=C(CCl)NC12CC3CC(CC(C3)C1)C2.O=C(O)C(F)(F)F.O=C([O-])[O-].[K+].[K+]>>NC(=O)C1CCN(CC(=O)NC23CC4CC(CC(C4)C2)C3)CC1",
        "output": "340"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.O=S(=O)(Nc1cccc2cc(CO)[nH]c12)c1cccs1.[Mn+4].[O-2].[O-2]>>O=Cc1cc2cccc(NS(=O)(=O)c3cccs3)c2[nH]1",
        "output": "263"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)[C@H](Cc1ccccc1)Nc1nccc(-c2ccc(OCc3ccccc3)cc2)n1.CCO.[Li+].[OH-]>>O=C(O)[C@H](Cc1ccccc1)Nc1nccc(-c2ccc(OCc3ccccc3)cc2)n1",
        "output": "278"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](C(=O)O)C1.CC(C)N1CC(=O)N(C)c2cnc(Nc3cc(N)cc(S(C)(=O)=O)c3)nc21>>CC(C)N1CC(=O)N(C)c2cnc(Nc3cc(NC(=O)[C@@H]4CCN(C(=O)OC(C)(C)C)C4)cc(S(C)(=O)=O)c3)nc21",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(S(=O)(=O)n2ccc3ncccc32)cc1.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cc1ccc(S(=O)(=O)n2ccc3c2ccc[n+]3[O-])cc1",
        "output": "820"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CN(C)NC(=O)c1cc2nccc(Oc3ccc([N+](=O)[O-])cc3F)c2s1.O.[Cl-].[Fe].[NH4+]>>CN(C)NC(=O)c1cc2nccc(Oc3ccc(N)cc3F)c2s1",
        "output": "335"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.N#Cc1ncc(N2C(=O)C3(CCC3)N(c3ccc(O)c(F)c3)C2=S)cc1C(F)(F)F.OCc1ccccc1>>N#Cc1ncc(N2C(=O)C3(CCC3)N(c3ccc(OCc4ccccc4)c(F)c3)C2=S)cc1C(F)(F)F",
        "output": "347"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)[C@](C)(O)C(F)(F)F.NN.O>>C[C@](O)(C(=O)NN)C(F)(F)F",
        "output": "130"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.Cc1nccc2c1[nH]c1ccc(-c3cccc(C#N)c3)cc12.Cl.O.[BH4-].[Na+]>>Cc1nccc2c1[nH]c1ccc(-c3cccc(CN)c3)cc12",
        "output": "175"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CCOC(C)=O.COC(=O)c1c2ccc3cc(OC)c(-c4cccc([N+](=O)[O-])c4)cc3c2nn1CCNC(=O)OC(C)(C)C.O.O.[Li+].[OH-]>>COc1cc2ccc3c(C(=O)O)n(CCNC(=O)OC(C)(C)C)nc3c2cc1-c1cccc([N+](=O)[O-])c1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCC(CCC)(C(=O)OC)c1ccccc1.COC(=O)C(C)(C)c1ccccc1>>CC(C)(C(=O)O)c1ccccc1",
        "output": "203"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Oc1cc(F)cc2c1ccn2-c1ccc(OCc2ccccc2)cc1.[Pd]>>Oc1ccc(-n2ccc3c(O)cc(F)cc32)cc1",
        "output": "698"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)N.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.O=C(O)c1cc(Oc2ccc(Nc3ncnc4ccn(CCOCCO)c34)cc2Cl)cc(C(F)(F)F)c1.On1nnc2ccccc21>>CC(C)(C)NC(=O)c1cc(Oc2ccc(Nc3ncnc4ccn(CCOCCO)c34)cc2Cl)cc(C(F)(F)F)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCCSc1ncccc1C(=O)O.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCCSc1ncccc1CO",
        "output": "293"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)NC(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CNC.COc1ccccc1-c1cn(S(=O)(=O)c2ccc(C)cc2)c2ncc(-c3cncc(CC(=O)O)n3)cc12.F[P-](F)(F)(F)(F)F>>COc1ccccc1-c1cn(S(=O)(=O)c2ccc(C)cc2)c2ncc(-c3cncc(CC(=O)N(C)C)n3)cc12",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C1=C2[C@H]3CC[C@@H]4[C@@]5(C)CC[C@H](OC(=O)CC(C)(C)C(=O)O)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]3(C)CC[C@@]2([C@@H](O)CNCc2ccc(Cl)cc2)CC1=O.CCN(CC)CC.CCOC(C)=O.CN(C)CC=O.CO.Cl.ClCCl.O.[BH3-]C#N.[Na+]>>CC(C)C1=C2[C@H]3CC[C@@H]4[C@@]5(C)CC[C@H](OC(=O)CC(C)(C)C(=O)O)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]3(C)CC[C@@]2([C@@H](O)CN(CCN(C)C)Cc2ccc(Cl)cc2)CC1=O",
        "output": "858"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1nc2ccccc2cc1NC(=O)Oc1ccccc1.c1cc(OCC2CC2)cc(N2CCNCC2)c1>>COc1nc2ccccc2cc1NC(=O)N1CCN(c2cccc(OCC3CC3)c2)CC1",
        "output": "525"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCNCc1cc(C(F)(F)F)ccc1-c1cncc(CC(=O)OC)c1.Cl.Cl.O=C(O)Cc1ccccc1>>CCN(Cc1cc(C(F)(F)F)ccc1-c1cncc(CC(=O)OC)c1)C(=O)Cc1ccccc1",
        "output": "633"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Fc1ccc(-c2ccc(Cl)nn2)cc1.OC1CN2CCC1CC2.[H-].[Na+]>>Fc1ccc(-c2ccc(OC3CN4CCC3CC4)nn2)cc1",
        "output": "407"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(=O)c1ccc(Cl)cc1.CCO.Cl.NO.c1ccncc1>>CCC(=NO)c1ccc(Cl)cc1",
        "output": "212"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)c1nc(-c2cc(Cl)c(C3CC3)cn2)no1.OCC1CCCO1>>CC(C)(C)c1nc(-c2cc(OCC3CCCO3)c(C3CC3)cn2)no1",
        "output": "651"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.Cl.ClCCl.NCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(Cl)c1ccc(F)c(C(F)(F)F)c1>>O=C1CCC(N2C(=O)c3cccc(CNC(=O)c4ccc(F)c(C(F)(F)F)c4)c3C2=O)C(=O)N1",
        "output": "411"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1CC(C(=O)O)CN1C(=O)OC(C)(C)C.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1cc(N)ccc1F.ClCCl.F[P-](F)(F)(F)(F)F>>Cc1cc(NC(=O)C2CC(C)N(C(=O)OC(C)(C)C)C2)ccc1F",
        "output": "365"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccccc1.Cl.O.O=[N+]([O-])c1ccc(Cl)nc1.Oc1ccc(Br)cc1.[Br-].[Na+].[OH-]>>O=[N+]([O-])c1ccc(Oc2ccc(Br)cc2)nc1",
        "output": "516"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC1NC(=O)c2c1cc(F)c(F)c2Nc1ccccc1Cl.CCOC(C)=O.CO.O=C1CCC(=O)N1I>>CC1NC(=O)c2c1cc(F)c(F)c2Nc1ccc(I)cc1Cl",
        "output": "834"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cc(OCc3ccccc3)ccc12.[Pd]>>Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cc(O)ccc12",
        "output": "23"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1n[nH]c(C)c1Cc1ccc(F)cc1.N#Cc1ccc(F)c(Cl)c1>>Cc1nn(-c2ccc(C#N)cc2Cl)c(C)c1Cc1ccc(F)cc1",
        "output": "751"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc(CC(=O)O)ccc1OC(C)=O.ClCCl.II.O=C([O-])C(F)(F)F.[Ag+]>>COc1cc(CC(=O)O)c(I)cc1OC(C)=O",
        "output": "372"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(CC(=O)O)Nc1ccc(F)c(Cl)c1.O.[Na+].[OH-]>>CC1CC(=O)c2c(ccc(F)c2Cl)N1",
        "output": "274"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(N2CCC(N3CCCC3C)C2)ccc1N.O=C(O)c1ccc2c(c1)OCCO2>>Cc1cc(N2CCC(N3CCCC3C)C2)ccc1NC(=O)c1ccc2c(c1)OCCO2",
        "output": "50"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1nc(Cl)ccc1Nc1cncnc1.Cl.[Li+].[OH-]>>O=C(O)c1nc(Cl)ccc1Nc1cncnc1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CCN(C(C)C)C(C)C.COc1cc2c(Sc3cccc(NC(=O)Nc4cc(C(C)(C)C)on4)c3)ncnc2cc1OCCCl.OCCN1CCNCC1.[I-]>>COc1cc2c(Sc3cccc(NC(=O)Nc4cc(C(C)(C)C)on4)c3)ncnc2cc1OCCN1CCN(CCO)CC1",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCO[C@@H](CO)C1.CC(C)(C)OC(=O)N1CCO[C@H](CO)C1>>CN1CCO[C@@H](CO)C1",
        "output": "881"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O.O=Cc1cc(C(=O)O)cs1.[BH4-].[Na+]>>O=C(O)c1csc(CO)c1",
        "output": "529"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.COC(=O)COc1ccc(S)cc1C.FC(F)(F)c1ccc(-c2ccc(CCBr)cc2)cc1.O.O=C([O-])[O-].[Cl-].[Cs+].[Cs+].[Na+]>>COC(=O)COc1ccc(SCCc2ccc(-c3ccc(C(F)(F)F)cc3)cc2)cc1C",
        "output": "124"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)C1CCCC1=O.Cl.O.[Na+].[OH-]>>O=C(O)C1CCCC1=O",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.O=C(O)c1cc([N+](=O)[O-])cc(C(F)(F)F)c1.[Pd]>>Nc1cc(C(=O)O)cc(C(F)(F)F)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2nc3cc(C#N)ccc3o2)cc1.O.[Na+].[OH-]>>N#Cc1ccc2oc(-c3ccc(C(=O)O)cc3)nc2c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)/C=C/c1cnn(C)c1-c1cccnc1.CO.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>Cn1ncc(/C=C/C(=O)O)c1-c1cccnc1",
        "output": "122"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCOCC1.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccc(C2CCNCC2)cc1>>O=C(N1CCC(c2ccccc2)CC1)C(F)(F)F",
        "output": "397"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCC(=O)c1cc2c(=O)c(C(=O)OCC)cn(CC)c2cc1C.CCO.[Na+].[OH-]>>CCCC(=O)c1cc2c(=O)c(C(=O)O)cn(CC)c2cc1C",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)c1ccc(B(O)O)cc1.CCCC(C(=O)OC)c1c(C)nc(-c2ccccc2)nc1Cl.CCN(C(C)C)C(C)C.COCCOC.O.[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCC(C(=O)OC)c1c(C)nc(-c2ccccc2)nc1-c1ccc(C(C)C)cc1",
        "output": "884"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.C[O-].Cn1nc(-c2ccc(Cl)c(CBr)c2)c(Cl)c1OC(F)F.[Na+]>>COCc1cc(-c2nn(C)c(OC(F)F)c2Cl)ccc1Cl",
        "output": "464"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.CN(C)C(=O)c1ccc(C(=O)O)cc1.CN(C)C=O.Cl.Cl.N#Cc1ccc(I)c(OCCN)c1>>CN(C)C(=O)c1ccc(C(=O)NCCOc2cc(C#N)ccc2I)cc1",
        "output": "902"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)[C@@H](CO)C1.ClCCl.[Ca+2].[OH-].[OH-]>>CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)[C@@H](C=O)C1",
        "output": "610"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.Clc1ccc(N2CCNCC2)cc1.Clc1nc2c(c(Nc3cccc(CN4CCOCC4)c3)n1)SCC2.O>>Clc1ccc(N2CCN(c3nc4c(c(Nc5cccc(CN6CCOCC6)c5)n3)SCC4)CC2)cc1",
        "output": "36"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "N#Cc1ccc(Cl)cc1F.O=S(=O)(O)O.O=[N+]([O-])O>>N#Cc1cc([N+](=O)[O-])c(Cl)cc1F",
        "output": "21"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCn1c(=O)n(Cc2ccccc2F)c(=O)c2[nH]c(Cc3ccc(N)cc3)nc21.O=S(=O)(Cl)Cc1ccccc1>>CCCCn1c(=O)n(Cc2ccccc2F)c(=O)c2[nH]c(Cc3ccc(NS(=O)(=O)Cc4ccccc4)cc3)nc21",
        "output": "194"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1.CO.[Ni]>>CCN1CCN(Cc2ccc(N)cc2)CC1",
        "output": "507"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1CCC(=O)c2ccccc21.CO.Cl.NO.O=C([O-])O.[Na+]>>CC1CCC(=NO)c2ccccc21",
        "output": "212"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.Nc1ccc(S(=O)(=O)Nc2nccs2)cc1.O=C(Cl)C(Cl)c1ccccc1.c1ccncc1>>O=C(Nc1ccc(S(=O)(=O)Nc2nccs2)cc1)C(Cl)c1ccccc1",
        "output": "9"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(Br)CC.COc1ccc(-c2nc(CCC(=O)c3ncccc3C)co2)cc1O>>CCC(CC)Oc1cc(-c2nc(CCC(=O)c3ncccc3C)co2)ccc1OC",
        "output": "153"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.COC(=O)CBr.O=C([O-])[O-].Oc1ccc(C2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1.[K+].[K+]>>COC(=O)COc1ccc(C2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1",
        "output": "557"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CCCCn1c(N)cc(=O)[nH]c1=O.CO.C[Si](C)(C)N[Si](C)(C)C.II.O=S(=O)([O-])[O-].[NH4+].[NH4+]>>CCCCn1c(N)cc(=O)n(Cc2ccccc2)c1=O",
        "output": "389"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@H](C(=O)O)CC1.ClCCCl.N.On1nnc2ccccc21>>CC(C)(C)OC(=O)N[C@H]1CC[C@@H](C(N)=O)CC1",
        "output": "313"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCN(CCO)S(=O)(=O)c1cccc2cnccc12.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.ClC(Cl)Cl.c1ccncc1>>CCCCCCN(CCOS(=O)(=O)c1ccc(C)cc1)S(=O)(=O)c1cccc2cnccc12",
        "output": "197"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc(N)ccn1.ClCCl.F[P-](F)(F)(F)(F)F>>COc1cc(NC(=O)C2NC(CC(C)(C)C)C(C#N)(c3ccc(Cl)cc3F)C2c2cccc(Cl)c2F)ccn1",
        "output": "563"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)C1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CCO1.O.[Li+].[OH-]>>O=C(O)C1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CCO1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.N#Cc1cccc(Oc2ccccc2Cl)c1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>NCc1cccc(Oc2ccccc2Cl)c1",
        "output": "175"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CN1CCC(Oc2ccc([N+](=O)[O-])c(-c3ccccc3)c2)CC1.[Pd]>>CN1CCC(Oc2ccc(N)c(-c3ccccc3)c2)CC1",
        "output": "202"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.O=S(=O)(Nc1cccc(-c2nc(N3CCOCC3)sc2-c2ccnc(Cl)n2)c1Cl)c1ccoc1.[NH4+].[OH-]>>Nc1nccc(-c2sc(N3CCOCC3)nc2-c2cccc(NS(=O)(=O)c3ccoc3)c2Cl)n1",
        "output": "312"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.COc1cccc(C(=O)NC(C)(CO)C(C)C)c1C.ClCCl.O=C([O-])O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>COc1cccc(C(=O)NC(C)(C=O)C(C)C)c1C",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.COC(=O)c1cccc(-c2nc(COc3ccc(C=O)cc3)c(C)o2)c1.O.[BH4-].[Na+]>>COC(=O)c1cccc(-c2nc(COc3ccc(CO)cc3)c(C)o2)c1",
        "output": "356"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C(=O)O)cc1.Cc1cccc(C)c1Oc1ccc2ccc(N)nc2n1.O>>COc1ccc(C(=O)Nc2ccc3ccc(Oc4c(C)cccc4C)nc3n2)cc1",
        "output": "744"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C(=O)OC(C)(C)C)c1ccc(-c2cnc3nc(-c4cc(NC(=O)N5CCCC5)ccc4Cl)cn3c2)cc1.ClCCl.O=C(O)C(F)(F)F>>CNc1ccc(-c2cnc3nc(-c4cc(NC(=O)N5CCCC5)ccc4Cl)cn3c2)cc1",
        "output": "830"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN1C(=N)/C(=C/c2ccc(O)c(OC)c2)NC1=O.Cc1ccc(S(=O)(=O)Cl)cc1.[Cl-].[NH4+].c1ccncc1>>CCN1C(=N)/C(=C/c2ccc(OS(=O)(=O)c3ccc(C)cc3)c(OC)c2)NC1=O",
        "output": "380"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)O.CCCC(=O)O[C@H](C)c1nccc(Cl)n1.CCN(CC)CC.c1cc2nc(N3CCNCC3)oc2cn1>>CCCC(=O)O[C@H](C)c1nccc(N2CCN(c3nc4ccncc4o3)CC2)n1",
        "output": "162"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.O.O=C1CCC(=O)N1Br.c1ccc2c(c1)ccc1c3ccccc3c3ccccc3c21>>Brc1cc2c3ccccc3c3ccccc3c2c2ccccc12",
        "output": "4"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.COc1cc2c(Cl)ncnc2cc1OCc1ccccc1.O=C(Nc1ccc(F)cc1)C1(C(=O)Nc2ccc(O)c(F)c2)CC1.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ncnc2cc1OCc1ccccc1",
        "output": "668"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc2c(OC)ccnc2c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1ccnc2cc(CO)ccc12",
        "output": "444"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1cc(C(=O)O)cc(-c2ccccc2)c1.O=S(=O)(O)O>>COC(=O)c1cc(C)cc(-c2ccccc2)c1",
        "output": "33"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCc1ccccc1N.Cn1cnc2cnc(Cl)cc21.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CCc1ccccc1Nc1cc2c(cn1)ncn2C",
        "output": "352"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2cc(-c3csc(NC(C)C)n3)nc3cc(OC)ccc23)CN1C(=O)OC(C)(C)C)C(=O)NS(=O)(=O)c1ccccc1NCCOCCOCCC(=O)OC.CO.O.[Li+].[OH-]>>C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2cc(-c3csc(NC(C)C)n3)nc3cc(OC)ccc23)CN1C(=O)OC(C)(C)C)C(=O)NS(=O)(=O)c1ccccc1NCCOCCOCCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1ccc(-c2ccc3c(c2)c(Cc2ccccc2)c(C)n3C)cc1.ClCCl>>Cc1c(Cc2ccccc2)c2cc(-c3ccc(O)cc3)ccc2n1C",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(CNC(=O)c1ccc(Cl)nn1)C1CC1.CCCC[N+](CCCC)(CCCC)CCCC.O=C([O-])[O-].O=C1N(C2CCNCC2)c2ccccc2C1(F)F.[I-].[K+].[K+]>>CC(CNC(=O)c1ccc(N2CCC(N3C(=O)C(F)(F)c4ccccc43)CC2)nn1)C1CC1",
        "output": "406"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCN(C2CCN(C(=O)[C@H](CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)Cc3cc(Br)c(N)c(C(F)(F)F)c3)CC2)CC1.CO.[Pd]>>CN1CCN(C2CCN(C(=O)[C@H](CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)Cc3ccc(N)c(C(F)(F)F)c3)CC2)CC1",
        "output": "350"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)CC(=O)Cl.COC(=O)[C@H](CN)NC(=O)c1ccc(C#C/C=C/c2ccc(CN3CCOCC3)cc2)cc1.Cl.ClC(Cl)Cl>>COC(=O)[C@H](CNC(=O)CN(C)C)NC(=O)c1ccc(C#C/C=C/c2ccc(CN3CCOCC3)cc2)cc1",
        "output": "45"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)c1ccc(F)cc1.O=C1CCC(=O)N1Br.O=S(=O)(O)O>>CS(=O)(=O)c1ccc(F)c(Br)c1",
        "output": "4"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(NC(=O)OC(C)(C)C)c1nc2ncccc2cc1-c1ccccn1.ClCCl.O=C(O)C(F)(F)F>>CC(N)c1nc2ncccc2cc1-c1ccccn1",
        "output": "538"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.NCCO.O=C([O-])O.O=Cc1ccc(Cl)cc1.[BH4-].[Na+].[Na+]>>OCCNCc1ccc(Cl)cc1",
        "output": "468"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.CC(C)=O.O.O=C(NC1CCCCC1O)OCc1ccccc1.O=S(=O)(O)O.O=S(=O)(O)O.O=[Cr](=O)=O>>O=C(NC1CCCCC1=O)OCc1ccccc1",
        "output": "87"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)c1sc(-c2ccccc2)cc1N(C(=O)C1CC=C(C)C1)C(C)C.O.[Li]O>>CC1=CCC(C(=O)N(c2cc(-c3ccccc3)sc2C(=O)O)C(C)C)C1",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCc1cc2c(C(F)(F)F)c(C#N)ccc2n1Cc1noc(-c2cc(C(=O)O)ccc2Cl)n1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl>>CCCc1cc2c(C(F)(F)F)c(C#N)ccc2n1Cc1noc(-c2cc(C(=O)Cl)ccc2Cl)n1",
        "output": "448"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCCCC(=O)O.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NC(=NO)c1ccc(CO)cc1.O.O.On1nnc2ccccc21>>CCCCCCCc1nc(-c2ccc(CO)cc2)no1",
        "output": "926"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)CC1C(=O)[C@@]2(C)CC[C@@H]1C2(C)C.NN.O>>CC1(C)[C@H]2CC[C@]1(C)C(=O)C2CC(=O)NN",
        "output": "130"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)Nc1nc2cc(OC)ccc2nc1OC.Cc1cccc(N2CCNCC2)c1>>COc1ccc2nc(OC)c(NC(=O)N3CCN(c4cccc(C)c4)CC3)nc2c1",
        "output": "613"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC1(C)CCc2c(C)c(O)c(C)c(C)c2O1.CS(C)=O.ClCc1ccccc1.O.O=C([O-])[O-].[K+].[K+]>>COC1(C)CCc2c(C)c(OCc3ccccc3)c(C)c(C)c2O1",
        "output": "49"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)NCc1nc(-c2ccccc2)no1.CCN(CC)CC.O=C(Cl)COc1ccc(-c2ccccc2)cc1>>CC(C)N(Cc1nc(-c2ccccc2)no1)C(=O)COc1ccc(-c2ccccc2)cc1",
        "output": "125"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "N#Cc1ccc(Cl)nc1.NN.O.O>>N#Cc1ccc(NN)nc1",
        "output": "417"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1cnc(C(F)(F)F)nc1O.Cl.O.[Na+].[OH-]>>O=C(O)c1cnc(C(F)(F)F)nc1O",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CO.CS(=O)(=O)c1ccc(CC(=O)O)cc1.C[Si](C)(C)C=[N+]=[N-].ClCCl>>COC(=O)Cc1ccc(S(C)(=O)=O)cc1",
        "output": "195"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)C1(C)CCCN(C(=O)OCc2ccccc2)C1.[Li+].[OH-]>>CC1(C(=O)O)CCCN(C(=O)OCc2ccccc2)C1",
        "output": "281"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CBr.CN(C)C=O.CN(Cc1cc(C2=CCCCC2)n(S(=O)(=O)c2cccc(O)c2)c1)C(=O)OC(C)(C)C.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)COc1cccc(S(=O)(=O)n2cc(CN(C)C(=O)OC(C)(C)C)cc2C2=CCCCC2)c1",
        "output": "123"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.CS(C)=O.Cc1nc(N2CCC(N)CC2)c2ccsc2n1.Cl.OCc1cccc(OCC2CO2)c1>>Cc1nc(N2CCC(NCC(O)COc3cccc(CO)c3)CC2)c2ccsc2n1",
        "output": "16"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)N(c1ccccc1)C1(c2nc(C)cs2)CCNCC1.CCOC(C)=O.ClC(Cl)Cl.O=C(Cl)c1ccccc1.c1ccncc1>>CC(=O)N(c1ccccc1)C1(c2nc(C)cs2)CCN(C(=O)c2ccccc2)CC1",
        "output": "201"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C=CCc1ccc(C(=O)OC)c(C)c1O.CO.Cl.[Na+].[OH-]>>C=CCc1ccc(C(=O)O)c(C)c1O",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(SC)c1cccc([N+](=O)[O-])c1.CO.Cl.[Sn]>>CCC(SC)c1cccc(N)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.Nc1cc(Cl)ncc1[N+](=O)[O-].[Ni]>>Nc1cnc(Cl)cc1N",
        "output": "269"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.II.O=Cc1ccc(O)c(OCc2ccccc2)c1.[Na+].[OH-]>>O=Cc1cc(I)c(O)c(OCc2ccccc2)c1",
        "output": "372"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COCCOc1ccc(C(F)(F)C(=O)O)cc1.Cl.NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O.O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+].c1ccncc1>>COCCOc1ccc(C(F)(F)C(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1",
        "output": "599"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#CCCCC.CCN(CC)CC.I[Cu]I.Nc1ccccc1I>>CCCCC#Cc1ccccc1N",
        "output": "664"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(C)cc(-c2c(-c3ccc(-c4ccccc4C(C)=O)nc3)cnn2CC#N)c1.CSC.ClCCl.FB(F)F>>CC(=O)c1ccccc1-c1ccc(-c2cnn(CC#N)c2-c2cc(C)cc(O)c2)cn1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C1Nc2ccc(OCCCCCl)cc2C(C2CCCCC2)(C2CCCCC2)O1.Sc1ccc(C2CCCCC2)cc1>>O=C1Nc2ccc(OCCCCSc3ccc(C4CCCCC4)cc3)cc2C(C2CCCCC2)(C2CCCCC2)O1",
        "output": "460"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC1(C)CCc2cc(B(O)O)ccc2O1.CCCc1nc(C)c(Br)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.Cl[Pd]Cl.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCCc1nc(C)c(-c2ccc3c(c2)CCC(C)(C)O3)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "871"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(C)=CCCC(C)CCO>>CC(C)=CCCC(C)CC=O",
        "output": "142"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.Cc1ccc(-c2ccc(Cl)cc2)cc1N.O.O=N[O-].[Na+]>>Cc1ccc(-c2ccc(Cl)cc2)cc1Br",
        "output": "373"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)C(Cc1ccccc1)Oc1ccc2cc(-c3cnc(-c4cn(Cc5ccccc5)c5ccccc45)o3)ccc2c1.Cl.[Na+].[OH-]>>O=C(O)C(Cc1ccccc1)Oc1ccc2cc(-c3cnc(-c4cn(Cc5ccccc5)c5ccccc45)o3)ccc2c1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=C(O)[C@@H]1C[C@@H](O)CN1.O=S(Cl)Cl>>COC(=O)[C@@H]1C[C@@H](O)CN1",
        "output": "536"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.N#CC1(c2cc(F)ccc2F)CCC(=O)CC1.[BH4-].[Na+]>>N#CC1(c2cc(F)ccc2F)CCC(O)CC1",
        "output": "91"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.ClCCCBr.O=C1Nc2ccccc2C1(F)F.[H-].[Na+]>>O=C1N(CCCCl)c2ccccc2C1(F)F",
        "output": "367"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)c1cc(CN=[N+]=[N-])cc(OC)c1.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1cc(CN)cc(OC)c1",
        "output": "562"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CNC.O.O=Cc1cc([N+](=O)[O-])ccc1Cl.[Na+]>>CN(C)Cc1cc([N+](=O)[O-])ccc1Cl",
        "output": "567"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(=O)O)c[nH]4)c3)cc2F)c1.Cl.OCCCN1CCOCC1>>Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(=O)OCCCN5CCOCC5)c[nH]4)c3)cc2F)c1",
        "output": "521"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1sc(-c2ccnc(NC(C)=O)c2)nc1-c1ccccc1Cl.Cl.O.O.[Li+].[OH-]>>CC(=O)Nc1cc(-c2nc(-c3ccccc3Cl)c(C(=O)O)s2)ccn1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1OC1CCNCC1(F)F.O=C(O)CO>>N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1OC1CCN(C(=O)CO)CC1(F)F",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCn1cc(-c2ccnc3c2cc(-c2ccc(NC(C)=O)cc2)n3S(=O)(=O)c2ccccc2)c(-c2ccc([N+](=O)[O-])cc2)n1.[H][H].[OH-].[OH-].[Pd+2]>>CCn1cc(-c2ccnc3c2cc(-c2ccc(NC(C)=O)cc2)n3S(=O)(=O)c2ccccc2)c(-c2ccc(N)cc2)n1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1C[C@H](Cc2ccc(Cl)c(Cl)c2)C[C@H]1CC#N>>CC(C)(C)OC(=O)N1C[C@H](Cc2ccc(Cl)c(Cl)c2)C[C@H]1CCN",
        "output": "246"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc(-c2ccncc2)nc1Cc1ccccc1.C#CC1(O)CN2CCC1CC2.CCN(CC)CC.CN(C)C=O.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>OC1(C#Cc2ccc(-c3ccncc3)nc2Cc2ccccc2)CN2CCC1CC2",
        "output": "719"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CNCCN1.Clc1nc(N2CCCCC2)c2nc(Cl)c(N3CCCCC3)nc2n1>>Clc1nc2c(N3CCCCC3)nc(N3CCNCC3)nc2nc1N1CCCCC1",
        "output": "214"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.COc1cc(C(=O)O)cc(C(F)(F)F)c1.On1nnc2ccccc21.[NH4+].[OH-]>>COc1cc(C(N)=O)cc(C(F)(F)F)c1",
        "output": "358"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(NC(=O)OC(C)(C)C)CCCN(c2ccncc2[N+](=O)[O-])C1.CO.N#N.[Pd]>>CC1(NC(=O)OC(C)(C)C)CCCN(c2ccncc2N)C1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.FC(F)(F)c1ccnc(Cl)n1.O=C([O-])[O-].Oc1ccccc1.[K+].[K+]>>FC(F)(F)c1ccnc(Oc2ccccc2)n1",
        "output": "542"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CC[C@H](O)[C@H](F)C1.CC(C)(C)[O-].N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1F.O.[K+]>>CC(C)(C)OC(=O)N1CC[C@H](Oc2ccc(-c3ncnc(Nc4ccc(N5CCN(C6COC6)CC5)cc4)n3)cc2C#N)[C@H](F)C1",
        "output": "485"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#Cc1c(C)cccc1C.C1COCCO1.CC(C)NC(C)C.N#Cc1c(F)c(F)c(Br)c(F)c1F.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Cc1cccc(C)c1C#Cc1c(F)c(F)c(C#N)c(F)c1F",
        "output": "659"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.COc1cc(C(N)=O)ccc1N(C)C.O=C([O-])[O-].O=P(Cl)(Cl)Cl.[Na+].[Na+]>>COc1cc(C#N)ccc1N(C)C",
        "output": "374"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCC.Cc1ccccc1NC(=O)Nc1ccc(CO)cc1.ClCCl.O=S(Cl)Cl>>Cc1ccccc1NC(=O)Nc1ccc(CCl)cc1",
        "output": "81"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(Cl)cc1B(O)O.Nc1c2c(nc3c(Br)cccc13)CN(C1CCC1)C2=O>>COc1ccc(Cl)cc1-c1cccc2c(N)c3c(nc12)CN(C1CCC1)C3=O",
        "output": "833"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COc1cc([N+](=O)[O-])c2nccc(C)c2c1OC.Cl>>COc1cc([N+](=O)[O-])c2nccc(C)c2c1O",
        "output": "402"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.O.O=C1CCC(=O)N1Br.Oc1ccc(-c2ccc3cc(O)ccc3c2)cc1>>Oc1ccc(-c2ccc3c(Br)c(O)ccc3c2)cc1",
        "output": "4"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.O=S(=O)(c1cccc2c(Cl)nccc12)N1CCC(O)C1>>O=C1CCN(S(=O)(=O)c2cccc3c(Cl)nccc23)C1",
        "output": "650"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.NCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2.O=C(O)CCc1c[nH]c2ccccc12.O=C(n1ccnc1)n1ccnc1>>O=C(CCc1c[nH]c2ccccc12)NCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)N1CCNCC1.CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CCl)c3)c2)c1>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN(C(C)C)CC4)c3)c2)c1",
        "output": "156"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(C)=O.CCOC(=O)C(C)Br.CN(c1ccc(O)cc1)c1cc2ccc(Cl)cc2c(Cl)n1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C(C)Oc1ccc(N(C)c2cc3ccc(Cl)cc3c(Cl)n2)cc1",
        "output": "455"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CC(O)CNC(=O)[C@@H](C)NC(=O)OC(C)(C)C.O>>CC(=O)CNC(=O)[C@@H](C)NC(=O)OC(C)(C)C",
        "output": "87"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCN(CCC(O)c3ccc(F)cc3)CC2)c1.Oc1ccc(C(F)(F)F)cc1>>CC(C)C(=O)Nc1cccc(C2CCN(CCC(Oc3ccc(C(F)(F)F)cc3)c3ccc(F)cc3)CC2)c1",
        "output": "342"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)c1ccc(O)c(C=O)c1.Cc1cccnc1C(=N)NN>>Cc1cccnc1-c1n[nH]c(-c2cc(C(C)(C)C)ccc2O)n1",
        "output": "994"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNCC1.C1CCOC1.O=C=NCC1OC(=C2C(=O)Nc3ccccc32)c2ccccc21>>O=C1Nc2ccccc2C1=C1OC(CNC(=O)N2CCCCC2)c2ccccc21",
        "output": "437"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Nc1nncc2ccccc12.O=C(O)C1CCN(c2cccnn2)CC1>>O=C(Nc1nncc2ccccc12)C1CCN(c2cccnn2)CC1",
        "output": "795"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1cnn(-c2ccnc3[nH]ccc23)c1.CN(C)C=O.C[Si](C)(C)CCOCCl.[H-].[Na+]>>C[Si](C)(C)CCOCn1ccc2c(-n3cc(Br)cn3)ccnc21",
        "output": "712"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCCC(O)C1.CI.O.[H-].[Na+]>>COC1CCCN(C(=O)OC(C)(C)C)C1",
        "output": "140"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)NC(=O)c1cc(-c2ccc(CN)cn2)n(-c2ccccc2)n1.CCN(CC)CC.CO.ClCCl.O=C(Cl)C1CCCC1>>CC(C)(C)NC(=O)c1cc(-c2ccc(CNC(=O)C3CCCC3)cn2)n(-c2ccccc2)n1",
        "output": "45"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)c1ccc(C[C@@H]2CN(Cc3ccccc3)CCN2C(=O)c2ncn(C3Cc4ccccc4C3)c2-c2ccccc2)cc1.[K+].[OH-]>>O=C(O)c1ccc(C[C@@H]2CN(Cc3ccccc3)CCN2C(=O)c2ncn(C3Cc4ccccc4C3)c2-c2ccccc2)cc1",
        "output": "5"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc2ncnc(Oc3ccc4c(C(=O)O)cccc4c3)c2cc1OC.COc1ccc(NC(=O)c2ccc(CN)cc2)c(N)c1>>COc1ccc(NC(=O)c2ccc(CNC(=O)c3cccc4cc(Oc5ncnc6cc(OC)c(OC)cc56)ccc34)cc2)c(N)c1",
        "output": "753"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.O=C(Cl)C1CCN(c2ccncc2)CC1.O=S(=O)(NC1CCNCC1)c1ccc2ccccc2c1>>O=C(C1CCN(c2ccncc2)CC1)N1CCC(NS(=O)(=O)c2ccc3ccccc3c2)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=O)NC(C)(C)Cc1ccccc1.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>CCC(=O)NC(C)(C)Cc1ccc([N+](=O)[O-])cc1",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cc1ccccc1S(=O)(=O)NC(=O)c1cccc([N+](=O)[O-])c1.O.[Pd]>>Cc1ccccc1S(=O)(=O)NC(=O)c1cccc(N)c1",
        "output": "489"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.CC(=O)O.O=Cc1c(O)ccc2ccccc12.O=S([O-])([O-])=S.[Na+].[Na+]>>O=Cc1c(O)ccc2cc(Br)ccc12",
        "output": "98"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NC[C@@H](F)CO.O>>CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)NC[C@@H](F)CO",
        "output": "674"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCOC(=O)c1cnc2c(cnn2CC)c1Cl.O.[K+].[OH-]>>CCn1ncc2c(Cl)c(C(=O)O)cnc21",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCSc1ccccc1C(=O)O.CN(C)C=O.ClC(Cl)Cl.O=C(Cl)C(=O)Cl>>CCSc1ccccc1C(=O)Cl",
        "output": "448"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(C)=O.C[O-].Cc1cn(-c2c(F)cc([N+](=O)[O-])cc2F)cn1.[Na+]>>COc1cc([N+](=O)[O-])cc(F)c1-n1cnc(C)c1",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[C@H](NS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@H](CO)Cc1ccccc1.CCN(CC)CC.CCOC(C)=O.CS(C)=O.ClCCl>>CC(C)(C)[C@H](NS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@H](C=O)Cc1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(O)CC1CCNCC1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.Cl.O=C(O)c1cc2ccccc2[nH]1.On1nnc2ccccc21>>CC(O)CC1CCN(C(=O)c2cc3ccccc3[nH]2)CC1",
        "output": "605"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.CN.CN(C)C=O.Cl.O=C(O)Cc1cccc(Br)c1.On1nnc2ccccc21>>CNC(=O)Cc1cccc(Br)c1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.ClCC1CO1.N#Cc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>N#Cc1ccc(OCC2CO2)cc1",
        "output": "15"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCn2c1cc(Cl)nc2=O.N#Cc1cc(CO)ccc1Oc1ccc(C(F)(F)F)nc1.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCn2c1cc(OCc1ccc(Oc3ccc(C(F)(F)F)nc3)c(C#N)c1)nc2=O",
        "output": "653"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COc1cc(Nc2nc3c(c(Cc4ccccc4)n2)CN(C(=O)OC(C)(C)C)CC3)ccc1-n1cnc(C)c1.Cl>>COc1cc(Nc2nc3c(c(Cc4ccccc4)n2)CNCC3)ccc1-n1cnc(C)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.O.O=C(CBr)N[C@@H]1CC[C@@H](Nc2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1.O=C([O-])[O-].[K+].[K+]>>O=C(CN1CCCC1)N[C@@H]1CC[C@@H](Nc2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1",
        "output": "443"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CCN=C=O.COc1ccc2cccc(C(CN)CO)c2c1.Cl>>CCNC(=O)NCC(CO)c1cccc2ccc(OC)cc12",
        "output": "244"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC.CCOC(C)=O.CN(C)c1ccncc1.Cc1cc(N2CCNCC2)c2c(Cl)cccc2n1.ClCCl.O=C=Nc1ccc(F)cc1>>Cc1cc(N2CCN(C(=O)Nc3ccc(F)cc3)CC2)c2c(Cl)cccc2n1",
        "output": "323"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCC.CO.C[Si](C)(C)C=[N+]=[N-].Cc1ccccc1.O=C(O)c1ccc([N+](=O)[O-])cc1O>>COC(=O)c1ccc([N+](=O)[O-])cc1O",
        "output": "195"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Clc1cnccn1.O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](N2CCNCC2)[C@H](c2ccccc2)C1>>O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](N2CCN(c3cnccn3)CC2)[C@H](c2ccccc2)C1",
        "output": "505"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(C)(C)c1cc(CN)n(-c2cccc(Cl)c2)n1.CN(C)c1ccncc1.O=C(Nc1ccccn1)Oc1ccccc1>>CC(C)(C)c1cc(CNC(=O)Nc2ccccn2)n(-c2cccc(Cl)c2)n1",
        "output": "488"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)CCN1C(=O)c2ccccc2C1=O.CO.Cl.NO.O=C([O-])O.[Na+].[Na+].[OH-]>>CC(CCN1C(=O)c2ccccc2C1=O)=NO",
        "output": "86"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CNCc1ccc(C(=O)N2CC3(C)CC2CC(C)(C)C3)cc1.O=C(O)c1cccc2c1OC(F)(F)O2>>CN(Cc1ccc(C(=O)N2CC3(C)CC2CC(C)(C)C3)cc1)C(=O)c1cccc2c1OC(F)(F)O2",
        "output": "794"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(=O)(=O)Cl.ClCCl.Nc1cc([C@@H](O)CN(Cc2ccccc2)[C@H](CO)Cc2ccc(Oc3ccccn3)cc2)ccc1OCc1ccccc1.O.c1ccncc1>>CS(=O)(=O)Nc1cc([C@@H](O)CN(Cc2ccccc2)[C@H](CO)Cc2ccc(Oc3ccccn3)cc2)ccc1OCc1ccccc1",
        "output": "194"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCCC(C)CC(C)CC(=O)OCC.CO.O.[Na+].[OH-]>>CCCCCCCC(C)CC(C)CC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].O=C(c1ccc(O)cc1)c1ccc(O)cc1.OCCCl.[Cs+].[Cs+].[I-].[Na+]>>O=C(c1ccc(O)cc1)c1ccc(OCCO)cc1",
        "output": "74"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1ccc(N)c(Cl)c1.Cc1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>Nc1ccc(CO)cc1Cl",
        "output": "444"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)CC(C)=O.CC(C)O.CCN.CCN(CC)CC.CO.COC(=O)CC[C@H](N)C(=O)O.O=CO>>CCNC(=O)CC[C@H](N)C(=O)O",
        "output": "392"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Nc1ccc(Cl)cc1C(=O)c1ccccc1.O=S(=O)(Cl)c1ccc2c(c1)OCC2>>O=C(c1ccccc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc2c(c1)OCC2",
        "output": "68"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)N1CCOC(COCc2ccccc2)C1.CCO.[Pd]>>CC(C)(C)N1CCOC(CO)C1",
        "output": "178"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCO.Fc1ccc(Br)cc1CBr.O.[C-]#N.[K+]>>N#CCc1cc(Br)ccc1F",
        "output": "39"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOCC.CN(C)CCCCN(CCC#N)C(=O)OC(C)(C)C.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CN(C)CCCCN(CCCN)C(=O)OC(C)(C)C",
        "output": "246"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCNCC.CCOCC.CN(C)C=O.O.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(CBr)cc1>>CCN(CC)C(=O)c1ccc(CBr)cc1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.ClCCl.O.O=C(O)c1cc(-c2ccc(O)cc2)nc2c1c(C1CC1)nn2C1CCCCO1>>CC(C)(C)OC(=O)N1CCN(C(=O)c2cc(-c3ccc(O)cc3)nc3c2c(C2CC2)nn3C2CCCCO2)CC1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)/C=C(\\c1ccccc1)c1ccncc1.CO.O.[Na+].[OH-]>>O=C(O)/C=C(\\c1ccccc1)c1ccncc1",
        "output": "122"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(c1ccc([N+](=O)[O-])cc1OC(=O)c1ccccc1)c1ccc([N+](=O)[O-])cc1OC(=O)c1ccccc1.CCO.NN.[Pd]>>CC(C)(c1ccc(N)cc1OC(=O)c1ccccc1)c1ccc(N)cc1OC(=O)c1ccccc1",
        "output": "204"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CC=C(c2ccc(N)c3ccccc23)CC1.CO.[Pd]>>CC(C)(C)OC(=O)N1CCC(c2ccc(N)c3ccccc23)CC1",
        "output": "806"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN(C)C=O.COC(=O)C1(N)Cc2ccccc2C1.COc1ccc(C(=O)O)cc1OC(C)=O.Cl.ClCCl.O=C(Cl)C(=O)Cl.O=C([O-])O.[Na+]>>COC(=O)C1(NC(=O)c2ccc(OC)c(OC(C)=O)c2)Cc2ccccc2C1",
        "output": "652"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "N#Cc1cc(Br)c2c(c1)cc1n2CCNC1=O.OB(O)c1ccc(Cl)c(C(F)(F)F)c1>>N#Cc1cc(-c2ccc(Cl)c(C(F)(F)F)c2)c2c(c1)cc1n2CCNC1=O",
        "output": "833"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)CCc1nc(-c2ccc(C)c(NC(=O)c3cnc4ccccn34)c2)no1.C[Mg]Br>>Cc1ccc(-c2noc(CCC(C)(C)O)n2)cc1NC(=O)c1cnc2ccccn12",
        "output": "514"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCC(CC)C(c1ccc(NC(=O)CCl)cc1)n1cncn1.CN1CCNCC1.O.O=C([O-])[O-].[K+].[K+]>>CCC(CC)C(c1ccc(NC(=O)CN2CCN(C)CC2)cc1)n1cncn1",
        "output": "340"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.Cc1cc(C=O)ccc1O.Cc1ccccc1.OCc1ccc(Cl)c(Cl)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(C=O)ccc1OCc1ccc(Cl)c(Cl)c1",
        "output": "347"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C#N)c1ccc(Oc2ccc3c(c2)S(=O)(=O)NC2CCCN32)cc1.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[H-].[Li+].[Na+]>>CC(CN)c1ccc(Oc2ccc3c(c2)S(=O)(=O)NC2CCCN32)cc1",
        "output": "246"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)S(=O)(=O)Cl.CCN(CC)CC.NCCc1nccn1CCCCc1ccc(OCc2coc(/C=C/c3ccc(C(F)(F)F)cc3)n2)cc1>>CC(C)S(=O)(=O)NCCc1nccn1CCCCc1ccc(OCc2coc(/C=C/c3ccc(C(F)(F)F)cc3)n2)cc1",
        "output": "493"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)Oc1ccc(B(O)O)cc1.CCCc1nc(C)c(Br)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1F.CCOC(C)=O.Cl[Pd]Cl.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCCc1nc(C)c(-c2ccc(OC(C)C)cc2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1F",
        "output": "871"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cccc(C)c1F.O=[N+]([O-])O>>Cc1cc([N+](=O)[O-])cc(C)c1F",
        "output": "21"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)NC1CCC(=O)CC1.ClCCCl.ClCCl.N[C@@H]1C[C@H]1c1ccc(OCc2cccc(Br)c2)cc1.[Na+]>>CC(C)(C)OC(=O)NC1CCC(N[C@@H]2C[C@H]2c2ccc(OCc3cccc(Br)c3)cc2)CC1",
        "output": "236"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cc1ccc(Cn2c(NC3CCCN(CCO)CC3)nc3cccnc32)o1.Clc1ncccn1.O.[H-].[Na+]>>Cc1ccc(Cn2c(NC3CCCN(CCOc4ncccn4)CC3)nc3cccnc32)o1",
        "output": "37"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.O.O=C(O)c1c(F)cc(F)cc1F>>OCc1c(F)cc(F)cc1F",
        "output": "72"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN.Cc1cc(C(=O)NC(C)c2cnc(OCC(F)(F)F)c(Cl)c2)cc(C(=O)O)n1.Cl>>CCNC(=O)c1cc(C(=O)NC(C)c2cnc(OCC(F)(F)F)c(Cl)c2)cc(C)n1",
        "output": "137"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)CC(C)C.CCC(=O)N(c1ccccc1)C1(COC)CCNCC1.Cc1ccc(S(=O)(=O)OCCc2cccc3ccccc23)cc1.O.O=C([O-])[O-].[Na+].[Na+]>>CCC(=O)N(c1ccccc1)C1(COC)CCN(CCc2cccc3ccccc23)CC1",
        "output": "429"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCN(C)C(=O)c1ccc(NC(CCCCOC)c2oc3ccc(OC)cc3c2C)cc1.[Na+].[OH-]>>COCCCCC(Nc1ccc(C(=O)N(C)CCC(=O)O)cc1)c1oc2ccc(OC)cc2c1C",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CCn1c(=O)n(CCCOC)c(=O)c2cc([N+](=O)[O-])ccc21.[H][H].[Pd]>>CCn1c(=O)n(CCCOC)c(=O)c2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1cccc(C(=O)O)c1F.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>O=C(O)c1cccc(CBr)c1F",
        "output": "29"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)cc1NCC1CCCCC1.Cl.O.[Na+].[OH-]>>O=C(O)c1cnc(Nc2ccc(N3CCOCC3)cc2)cc1NCC1CCCCC1",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.O.O=C(Cl)OCc1ccccc1.OCCCC1CCNCC1>>O=C(OCc1ccccc1)N1CCC(CCCO)CC1",
        "output": "427"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.Cl.O.O=C(Nc1ccncc1)c1cc(Nc2nc(Cl)nc3ccoc23)n[nH]1.c1ccc(C2CCCN2)nc1>>O=C(Nc1ccncc1)c1cc(Nc2nc(N3CCCC3c3ccccn3)nc3ccoc23)n[nH]1",
        "output": "36"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CCOCCNC(=O)OC(C)(C)C.CCOC(C)=O.Cl>>CCN(CC)CCOCCN",
        "output": "538"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OCCCCCCCCOc1cccc([N+](=O)[O-])c1C#N.CCO.[Pd]>>CC(=O)OCCCCCCCCOc1cccc(N)c1C#N",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)C[AlH]CC(C)C.CCOC(=O)C(O)(c1ncc(-c2cc(C)cc(Nc3ncc(F)c(C4CC4)n3)c2)s1)C(F)(F)F>>Cc1cc(Nc2ncc(F)c(C3CC3)n2)cc(-c2cnc(C(O)(CO)C(F)(F)F)s2)c1",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCCCc1nc(C)[nH]c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCN(CC)CC.CCOC(C)=O.ClCCl.OB(O)c1cccc(Br)c1.[Cu+2].c1ccncc1>>CCCCc1nc(C)n(-c2cccc(Br)c2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "962"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.CCOC(=O)N1c2ccc(OC)nc2[C@@H](N)C[C@H]1C.Clc1ncc(Br)cn1>>CCOC(=O)N1c2ccc(OC)nc2[C@@H](Nc2ncc(Br)cn2)C[C@H]1C",
        "output": "544"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](C[C@H](CCCO)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C.CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCCC[C@@H](C[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)COc1ccc2cc(-c3cc4ccc(C(=O)CCC(C)(C)C)cc4s3)ccc2c1Br.Cl.O.[K+].[OH-]>>CC(C)(C)CCC(=O)c1ccc2cc(-c3ccc4c(Br)c(OCC(=O)O)ccc4c3)sc2c1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCC/C=C\\C/C=C\\CCCCCCCCC(O)CCCCCCCC/C=C\\C/C=C\\CCCCC.CCN(CC)CC.ClCCl.O=C(Cl)CCBr>>CCCCC/C=C\\C/C=C\\CCCCCCCCC(CCCCCCCC/C=C\\C/C=C\\CCCCC)OC(=O)CCBr",
        "output": "126"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc(Br)c2ccccc12.CCO.NO.O=Cc1ccc(Br)c2ccccc12>>ON=Cc1ccc(Br)c2ccccc12",
        "output": "30"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CSCC(C)N.Cc1ccccc1.Clc1cc(-c2ccnc(Cl)n2)ccn1>>CSCC(C)Nc1nccc(-c2ccnc(Cl)c2)n1",
        "output": "544"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCN(C(=O)c2cnn3ccc(N4CCC[C@@H]4c4cc(F)ccc4F)cc23)CC1CO.Cl>>O=C(c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)cc12)N1CCNC(CO)C1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)c1cc(O)ccc1OCc1ccccc1.CC(C)=O.ClCC1CO1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)c1cc(OCC2CO2)ccc1OCc1ccccc1",
        "output": "15"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.CCOC(C)=O.Cc1cc(-c2cccc(N)c2)cc(C)c1OCC1CCCN(C)C1.ClCCl.O.c1ccncc1>>CC(=O)Nc1cccc(-c2cc(C)c(OCC3CCCN(C)C3)c(C)c2)c1",
        "output": "6"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CC(=O)N(C)C.Nc1cn2nc(I)ccc2n1.O>>CC(=O)Nc1cn2nc(I)ccc2n1",
        "output": "399"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "FC(F)(F)c1ccc2c(Cl)ccnc2c1.Nc1ccc(S(=O)(=O)N2CCN(c3cccc(Cl)c3)CC2)cc1>>O=S(=O)(c1ccc(Nc2ccnc3cc(C(F)(F)F)ccc23)cc1)N1CCN(c2cccc(Cl)c2)CC1",
        "output": "115"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CI.O=C1c2cc(COc3ccccc3)nn2C[C@@H](CO)N1c1ccc(F)cc1.[H-].[Na+]>>COC[C@@H]1Cn2nc(COc3ccccc3)cc2C(=O)N1c1ccc(F)cc1",
        "output": "140"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNCC1.Cl.O.O=C(O)CC(=O)O.O=Cc1cccc([N+](=O)[O-])c1.c1ccncc1>>O=C(O)C=Cc1cccc([N+](=O)[O-])c1",
        "output": "12"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COc1c(C(=O)NC2CCN(C(=O)COC(C)=O)CC2)n(C)c2c1c(=O)n(Cc1ccc(C(F)(F)F)nc1C)c1ccccc21.O.O=C([O-])O.O=C([O-])[O-].[K+].[K+].[Na+]>>COc1c(C(=O)NC2CCN(C(=O)CO)CC2)n(C)c2c1c(=O)n(Cc1ccc(C(F)(F)F)nc1C)c1ccccc21",
        "output": "687"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cn1cc(C(=O)CC(c2ccc(C(=O)O)c(F)c2)c2ccccc2Cl)ccc1=O.F[P-](F)(F)(F)(F)F.NC1CCOCC1>>Cn1cc(C(=O)CC(c2ccc(C(=O)NC3CCOCC3)c(F)c2)c2ccccc2Cl)ccc1=O",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccccc1Oc1c(Cl)nc(Cl)nc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1.c1ccc(N2CCNCC2)cc1>>COc1ccccc1Oc1c(Cl)nc(N2CCN(c3ccccc3)CC2)nc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1",
        "output": "36"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CN1CCC(O)C1=O.NCCN>>NCCNC(=O)CN1CCC(O)C1=O",
        "output": "64"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CCOCCOc1ccc(OC)cc1CBr.CC(=O)Nc1cc(F)ccc1Oc1ccccc1>>C=CCOCCOc1ccc(OC)cc1CN(C(C)=O)c1cc(F)ccc1Oc1ccccc1",
        "output": "688"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCN.CCN(CC)CC.CCS(=O)(=O)CCCl.Cc1ccccc1>>CCCCNCCS(=O)(=O)CC",
        "output": "279"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(Nc1ccc(OC(F)(F)C(F)F)cc1)c1cnc(Cl)c(Br)c1.O[C@@H]1CCNC1>>O=C(Nc1ccc(OC(F)(F)C(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(Br)c1",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCN(C2CCNCC2)CC1.N#CCBr>>N#CCN1CCC(N2CCCCC2)CC1",
        "output": "880"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=C1CCC2(CC1)C(=O)Nc1cc(Br)ccc12.[BH4-].[Na+]>>O=C1Nc2cc(Br)ccc2C12CCC(O)CC2",
        "output": "91"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COc1ccc2c(C(=O)c3ccc(OCCN4CCCCC4)cc3)c(-c3ccccc3CO)ccc2c1.ClCCl.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1ccc2c(C(O)c3ccc(OCCN4CCCCC4)cc3)c(-c3ccccc3CO)ccc2c1",
        "output": "157"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOCCCl.Cc1cc(O)cc(C)c1Br>>CCOCCOc1cc(C)c(Br)c(C)c1",
        "output": "74"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.O=C1N[C@H](C(=O)O)Cc2ccc([N+](=O)[O-])cc21.O=[Pt]=O>>Nc1ccc2c(c1)C(=O)N[C@H](C(=O)O)C2",
        "output": "489"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)CON=C(C(=O)NC1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccccc3)CS[C@H]12)c1nccc(N)n1.CC(C)OC(C)C.COc1ccccc1.O=C(O)C(F)(F)F>>Nc1ccnc(C(=NOCC(=O)O)C(=O)NC2C(=O)N3C(C(=O)[O-])=C(C[n+]4ccccc4)CS[C@H]23)n1",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.Nc1cccc2nc3c(nc12)N1CCCCC1CO3.O=C(Cl)c1ccccc1.[Na+].[OH-]>>O=C(Nc1cccc2nc3c(nc12)N1CCCCC1CO3)c1ccccc1",
        "output": "501"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.COc1ccc(Cn2nc(-c3ccccc3)ccc2=O)cc1.ClCCl>>O=c1ccc(-c2ccccc2)nn1Cc1ccc(O)cc1",
        "output": "207"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)C(=O)Nc1ccc(-c2ccnc(Cl)n2)cc1.CCOC(=O)Cc1ccc(N)cc1.CCOC(=O)Cc1ccc(Nc2nccc(-c3ccc(NC(=O)C(C)C)cc3)n2)cc1.CCOC(C)=O.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)C(=O)Nc1ccc(-c2ccnc(Nc3ccc(CC(=O)O)cc3)n2)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CNC(=O)c1nn(C)cc1[N+](=O)[O-].[Pd]>>CNC(=O)c1nn(C)cc1N",
        "output": "628"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C([O-])[O-].O=Cc1cc(Br)ccc1O.[K+].[K+]>>O=Cc1cc(Br)ccc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCS(=O)(=O)Nc1nn(C(=O)OC(C)(C)C)c2ccc(C3C(C#N)=C(C)NC(C)=C3C#N)cc12.ClCCl.O=C(O)C(F)(F)F>>CCCS(=O)(=O)Nc1n[nH]c2ccc(C3C(C#N)=C(C)NC(C)=C3C#N)cc12",
        "output": "896"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)[C@H](CC(C)C)NC(=O)Cc1ccc(NC(=O)Nc2ccccc2C)cc1.O.[K+].[OH-]>>Cc1ccccc1NC(=O)Nc1ccc(CC(=O)N[C@@H](CC(C)C)C(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCOC(=O)CCNC(=O)c1ccc(-c2nc(=O)o[nH]2)cc1.O.[Na+].[OH-]>>O=C(O)CCNC(=O)c1ccc(-c2nc(=O)o[nH]2)cc1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.N[C@@H](CC(=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)O.O>>CC(C)(C)OC(=O)N[C@@H](CC(=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)O",
        "output": "626"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(=O)(=O)c1ccc(Nc2ncnc3c(C4CCNCC4)coc23)c(F)c1.Cl.ClCCl.O.O=C(Cl)OCc1ccccc1.c1ccncc1>>CS(=O)(=O)c1ccc(Nc2ncnc3c(C4CCN(C(=O)OCc5ccccc5)CC4)coc23)c(F)c1",
        "output": "427"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COc1ccc(-c2ccc(C3(CC(=O)NOC4CCCCO4)CCN(S(C)(=O)=O)CCS3(=O)=O)s2)cc1.Cl>>COc1ccc(-c2ccc(C3(CC(=O)NO)CCN(S(C)(=O)=O)CCS3(=O)=O)s2)cc1",
        "output": "915"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.COc1cc2c(cc1OC)CC(=O)N(CC1CCCN(CCc3ccc(OCc4ccccc4)c(OC)c3)C1)CC2>>COc1cc(CCN2CCCC(CN3CCc4cc(OC)c(OC)cc4CC3=O)C2)ccc1O",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.ClCCl.Clc1nc(Cl)c2cccc(Br)c2n1>>Clc1nc(N2CCOCC2)c2cccc(Br)c2n1",
        "output": "296"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1(n2cnc(C)c2)CCC(F)(F)CC1.CO.N>>Cc1cn(C2(C(N)=O)CCC(F)(F)CC2)cn1",
        "output": "163"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C.C1COCCO1.CC#N.CCN(CC)CC.Cl.Nc1cccc(Oc2cccnc2)c1.O=C(Cl)c1ccn2c1CSC2c1cccnc1>>O=C(Nc1cccc(Oc2cccnc2)c1)c1ccn2c1CSC2c1cccnc1",
        "output": "642"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.C1COCCO1.CC(C)(CO[Si](C)(C)C(C)(C)C)c1ccc(C=O)cc1.Cl.O>>CC(C)(CO)c1ccc(C=O)cc1",
        "output": "708"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)N1Cc2cccnc2C1.ClCCl.O.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)N1Cc2ccc[n+]([O-])c2C1",
        "output": "262"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)COc1ccc2c(c1O)OC(C)(C)CC2=O.COS(=O)(=O)OC.[Na+].[OH-]>>COc1c(OCC(C)C)ccc2c1OC(C)(C)CC2=O",
        "output": "317"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.COC(=O)c1ccc2c(cnn2Cc2cc(OC(F)(F)F)ccc2OCC(C)C)c1.[Na+].[OH-]>>CC(C)COc1ccc(OC(F)(F)F)cc1Cn1ncc2cc(C(=O)O)ccc21",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COc1ccc(CCN)cc1F.Cl.Cl.ClCCl.O=C(Cl)C1(c2ccccc2Cl)CC1>>COc1ccc(CCNC(=O)C2(c3ccccc3Cl)CC2)cc1F",
        "output": "45"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC.CCN(CC)CC.CCOC(C)=O.CN(C)c1ccncc1.Cc1ccc([N+](=O)[O-])cc1N.Cl.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1ccc([N+](=O)[O-])cc1NC(=O)C(F)(F)F",
        "output": "106"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.Nc1nc(N2CCN(C(=O)COc3ccc(Cl)cc3)CC2)c2nc(Cl)ccc2n1.O.OB(O)c1ccc(C(F)(F)F)cc1.[F-].[K+]>>Nc1nc(N2CCN(C(=O)COc3ccc(Cl)cc3)CC2)c2nc(-c3ccc(C(F)(F)F)cc3)ccc2n1",
        "output": "865"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCCCCC.CCN.CO.COC(=O)CN(CCc1ccc(OCc2cccc(F)c2)c(OC)c1)CC1CC1.C[Al](C)C.Cc1ccccc1>>CCNC(=O)CN(CCc1ccc(OCc2cccc(F)c2)c(OC)c1)CC1CC1",
        "output": "392"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cl.O=C([O-])O.O=C1CSC(=O)N1Cc1ccc([N+](=O)[O-])cc1.[Fe].[Na+]>>Nc1ccc(CN2C(=O)CSC2=O)cc1",
        "output": "507"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "N#Cc1ccccc1.O.[Cl-].[Cl-].[N-]=[N+]=[N-].[Na+].[Na+].[OH-].[Zn+2]>>c1ccc(-c2nn[nH]n2)cc1",
        "output": "390"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)C1CN(Cc2ccccc2)CCC1c1ccsc1>>O=C(Cl)C1CN(Cc2ccccc2)CCC1c1ccsc1",
        "output": "56"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#C[C@]1(O)CCN(C)C1=O.COC(=O)c1nn(-c2cccc(Br)c2)c2ccnc(NC3CC3)c12>>COC(=O)c1nn(-c2cccc(C#C[C@]3(O)CCN(C)C3=O)c2)c2ccnc(NC3CC3)c12",
        "output": "659"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)C(=O)Cl.CCN(CC)C(=O)NC1(c2ccccc2Cl)C(=O)N(S(=O)(=O)c2ccc(N)cc2)c2ccc(Cl)cc21.c1ccncc1>>CCN(CC)C(=O)NC1(c2ccccc2Cl)C(=O)N(S(=O)(=O)c2ccc(NC(=O)C(C)(C)C)cc2)c2ccc(Cl)cc21",
        "output": "9"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1C[C@H]2CCCN2C[C@H]1c1cc[nH]n1.CCOC(C)=O.CN(C)C=O.Fc1ccc(CCl)cc1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1C[C@H]2CCCN2C[C@H]1c1ccn(Cc2ccc(F)cc2)n1",
        "output": "842"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1ncc2c(cc(-c3cccc(C(F)(F)F)c3)c(=O)n2Cc2ccccc2)c1O.C[O-].NCCC(=O)O.[Na+]>>O=C(O)CCNC(=O)c1ncc2c(cc(-c3cccc(C(F)(F)F)c3)c(=O)n2Cc2ccccc2)c1O",
        "output": "487"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.Cl.Cl.O.O=C(Cl)OCc1ccccc1.O=C([O-])O.O=c1[nH]c2ccc(NC3CC4(CCNCC4)C3)cc2o1.[Na+]>>O=C(OCc1ccccc1)N1CCC2(CC1)CC(Nc1ccc3[nH]c(=O)oc3c1)C2",
        "output": "427"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)C1(F)CCCN(C(=O)c2ccc(F)cc2)C1.O.[Na+].[OH-]>>O=C(c1ccc(F)cc1)N1CCCC(F)(C(=O)O)C1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CN(C)C=O.O.O=C(NCCBr)OCc1ccccc1.O=C([O-])[O-].Oc1ccc2c(c1)sc1ccccc12.[K+].[K+]>>O=C(NCCOc1ccc2c(c1)sc1ccccc12)OCc1ccccc1",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCn1ccc(O)c([N+](=O)[O-])c1=O.O=P(Cl)(Cl)Cl>>CCn1ccc(Cl)c([N+](=O)[O-])c1=O",
        "output": "177"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOc1cc(C(=O)CS(C)(=O)=O)cc(OCC)c1N.O.[BH4-].[Na+].[Na+].[OH-]>>CCOc1cc(C(O)CS(C)(=O)=O)cc(OCC)c1N",
        "output": "24"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)O[K].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CNC(=O)c1c(C23CCCC2C3)oc2cc(N(C)S(C)(=O)=O)c(Br)cc12.Cl[Pd]Cl.O.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CNC(=O)c1c(C23CCCC2C3)oc2cc(N(C)S(C)(=O)=O)c(B3OC(C)(C)C(C)(C)O3)cc12",
        "output": "942"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cc(C)nc(N2CC3CNCC3C2)n1.O=C(O)c1c(F)cccc1F>>Cc1cc(C)nc(N2CC3CN(C(=O)c4c(F)cccc4F)CC3C2)n1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCCl)ccc34)cc2)no1.CN(C)C=O.NCCO.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCNCCO)ccc34)cc2)no1",
        "output": "279"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)n1cc(CCO)c2ccnc(Cl)c21.CC(C)OC(=O)/N=N/C(=O)OC(C)C.Cc1ccccc1.Oc1ccc(OC(F)(F)F)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)n1cc(CCOc2ccc(OC(F)(F)F)cc2)c2ccnc(Cl)c21",
        "output": "478"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC1)CC(C(=O)O)C2.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CO.ClCCl.F[P-](F)(F)(F)(F)F.N>>CC(C)(C)OC(=O)N1CCC2(CC1)CC(C(N)=O)C2",
        "output": "313"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)CS(=O)(=O)Cl.C[Si](C)(C)CCOCn1ccc2nc(NC(=O)NC3CCCNC3)cnc21.Cl.Cl>>CC(C)CS(=O)(=O)N1CCCC(NC(=O)Nc2cnc3c(ccn3COCC[Si](C)(C)C)n2)C1",
        "output": "584"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O.O=[N+]([O-])c1cnc2ccc(Cl)nn12.OB(O)c1ccccc1.[Na+].[OH-].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=[N+]([O-])c1cnc2ccc(-c3ccccc3)nn12",
        "output": "866"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)O.CNC(=O)c1ccccc1Nc1nc(Cl)ncc1Cl.CS(=O)(=O)N1CC2CC(C1)c1cc(N)ccc12.O=C([O-])O.[Na+]>>CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)C2CC3CN(S(C)(=O)=O)C2)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCS(=O)(=O)Cl.NCc1ccc(Br)cc1F.c1ccncc1>>CCS(=O)(=O)NCc1ccc(Br)cc1F",
        "output": "742"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)[Si](Cl)(C(C)C)C(C)C.CCN(CC)CC.CN(C)c1ccncc1.COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(-c2ccc(C(=O)NC[C@H](O)CO)[nH]2)c1.ClCCl.O>>COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(-c2ccc(C(=O)NC[C@H](O)CO[Si](C(C)C)(C(C)C)C(C)C)[nH]2)c1",
        "output": "193"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCNCC1.COC(=O)[C@H](CC=O)C[C@@H](OC)c1ccc(F)cc1.[Na+]>>COC(=O)[C@@H](CCN1CCN(C(=O)OC(C)(C)C)CC1)C[C@@H](OC)c1ccc(F)cc1",
        "output": "484"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)CCN.ClCCl.O=C(Cl)c1ccccc1OCc1nc2ccccn2c1C#Cc1ccc(F)cc1>>CN(C)CCNC(=O)c1ccccc1OCc1nc2ccccn2c1C#Cc1ccc(F)cc1",
        "output": "271"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCOCCOCCBr.N#Cc1ccc(-c2ccc(O)cc2)cc1.O=C([O-])[O-].[K+].[K+]>>CCOCCOCCOc1ccc(-c2ccc(C#N)cc2)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.O=C(N[C@@H](CO)Cc1ccccc1)OCc1ccccc1>>O=C[C@@H](Cc1ccccc1)NC(=O)OCc1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.[Na+].c1ccc(-c2ccccn2)cc1>>[O-][n+]1ccccc1-c1ccccc1",
        "output": "262"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C.O.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "B.C1CCOC1.CO.CSC.O=C(O)Cc1ccc(F)c(F)c1>>OCCc1ccc(F)c(F)c1",
        "output": "231"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O.OC(CCl)CCc1cccnc1.Oc1ccc(-c2ccccc2)cc1.[Na+].[OH-]>>OC(CCc1cccnc1)COc1ccc(-c2ccccc2)cc1",
        "output": "74"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CCN.CCOC(=O)c1c(CCCOS(C)(=O)=O)[nH]c(C(=O)OC(C)(C)C)c1C.CCOC(C)=O.O.[Cl-].[Na+]>>CCOC(=O)c1c(CCCNCCN(CC)CC)[nH]c(C(=O)OC(C)(C)C)c1C",
        "output": "559"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CC(C)(C)OC(=O)N[C@@H]1CCN([C@@H]2CCCC[C@H]2O)C1.CCOC(C)=O.CN(C)C=O.O.[H-].[Na+]>>CC(C)(C)OC(=O)N[C@@H]1CCN([C@@H]2CCCC[C@H]2OCc2ccccc2)C1",
        "output": "464"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.ClCCl.O=C(O)CCCCCCCBr.O=S(Cl)Cl>>O=C(Cl)CCCCCCCBr",
        "output": "53"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Nc2nc3cc(O)ccc3o2)CC1.CN(C)C=O.COCCCBr.COCCCOc1ccc2oc(NC3CCNCC3)nc2c1.O=C([O-])[O-].[K+].[K+]>>COCCCOc1ccc2oc(NC3CCN(C(=O)OC(C)(C)C)CC3)nc2c1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)CC=CC(=O)O.CCNCC.CN(C)C=O.ClCCl.O=S(Cl)Cl>>CCN(CC)C(=O)C=CCC(C)C",
        "output": "517"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)[O-].CC1(C)c2ccccc2-c2ccc(Br)cc21.CCCCCC.Nc1ccc(Cl)cc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC1(C)c2ccccc2-c2ccc(Nc3ccc(Cl)cc3)cc21",
        "output": "405"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1ccc(S(=O)(=O)Cl)cc1.C[C@@H](COC(=O)N1CCC(Nc2ccccc2)CC1)N(Cc1ccccc1)Cc1ccccc1>>CCCc1ccc(S(=O)(=O)N(c2ccccc2)C2CCN(C(=O)OC[C@H](C)N(Cc3ccccc3)Cc3ccccc3)CC2)cc1",
        "output": "791"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)N(Cc1ccccc1)c1cc(Br)nc(N)c1[N+](=O)[O-].COCCN>>CCOC(=O)N(Cc1ccccc1)c1cc(NCCOC)nc(N)c1[N+](=O)[O-]",
        "output": "715"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCOC(=O)c1cnc(N2CCNCC2)c(Br)c1.O=C=Nc1ccccc1>>CCOC(=O)c1cnc(N2CCN(C(=O)Nc3ccccc3)CC2)c(Br)c1",
        "output": "323"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCOP(=O)(OCC)C(F)C(=O)O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1.O>>CCOP(=O)(OCC)C(F)C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1",
        "output": "365"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC[N+](CC)(CC)Cc1ccccc1.CI.Cl.Cn1cncc1C(O)(c1ccc(C=O)cc1)c1ccc2[nH]c(=O)cc(-c3cccc(Cl)c3)c2c1.O.[Cl-].[Na+].[OH-]>>Cn1cncc1C(O)(c1ccc(C=O)cc1)c1ccc2c(c1)c(-c1cccc(Cl)c1)cc(=O)n2C",
        "output": "191"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN(CCO)Cc1ccccc1.O=[N+]([O-])c1ccc(Br)cc1F.[H-].[Na+]>>CN(CCOc1cc(Br)ccc1[N+](=O)[O-])Cc1ccccc1",
        "output": "485"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.ClCCl.F[C@@H]1CCNCC[C@H]1Oc1cccc2ccc(-c3nnc4ccccn34)nc12.O=C([O-])[O-].O=CO.[Na+].[Na+]>>CN1CC[C@@H](F)[C@H](Oc2cccc3ccc(-c4nnc5ccccn45)nc23)CC1",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)C1(CCCn2c(=O)ccc3ccc(OC)cc32)CCN(CCOc2ccccc2)CC1.[Na+].[OH-]>>COc1ccc2ccc(=O)n(CCCC3(C(=O)O)CCN(CCOc4ccccc4)CC3)c2c1",
        "output": "281"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNC.CO.FCCOc1ccc2cc(-c3ccnc(Cl)n3)sc2c1>>CN(C)c1nccc(-c2cc3ccc(OCCF)cc3s2)n1",
        "output": "36"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C)[C@H](/C=C(\\Cl)C(F)(F)F)[C@@H]1C(=O)Cl.Cc1c(F)c(F)c(CO)c(F)c1F>>Cc1c(F)c(F)c(COC(=O)[C@H]2[C@@H](/C=C(\\Cl)C(F)(F)F)C2(C)C)c(F)c1F",
        "output": "126"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1cc(O)c2cc(Br)cc(OCc3ccccc3)c2n1.COC(=O)c1cc(O)c2cccc(OCc3ccccc3)c2n1>>O=C(O)c1cc(O)c2cc(Br)cc(OCc3ccccc3)c2n1",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)C(CC1CCCC1)N1C(=O)C(=O)c2ccccc21.O.O.[Li+].[OH-]>>O=C1C(=O)N(C(CC2CCCC2)C(=O)O)c2ccccc21",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C(=O)O)C(c1ccccc1)c1ccc2[nH]ccc2c1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1nccs1>>CC(C)(C(=O)Nc1nccs1)C(c1ccccc1)c1ccc2[nH]ccc2c1",
        "output": "681"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1c(-c2ccc(CC)cc2)csc1N1C(=O)c2ccccc2C1=O.CO.Cl.O.[Na+].[OH-]>>CCc1ccc(-c2csc(N3C(=O)c4ccccc4C3=O)c2C(=O)O)cc1",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.C[C@]12C[C@H](O)[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2C#N.Cl.c1ccncc1>>CC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CC[C@H](C#N)[C@@]4(C)C[C@H](O)[C@@H]32)C1",
        "output": "254"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1ccc2ncc(F)c(CC[C@H]3CC[C@H](N)CN3C(=O)OC(C)(C)C)c2n1.O=Cc1ccc2c(n1)NC(=O)CO2.[BH3-]C#N.[Na+]>>COc1ccc2ncc(F)c(CC[C@H]3CC[C@H](NCc4ccc5c(n4)NC(=O)CO5)CN3C(=O)OC(C)(C)C)c2n1",
        "output": "775"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(C(F)(F)F)cc1C(C)=O.ClB(Cl)Cl.ClCCl>>CC(=O)c1cc(C(F)(F)F)ccc1O",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.C[C@@H](N)CO.Cn1nc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)c2ccc(Cl)cc21.F[P-](F)(F)(F)(F)F.On1nnc2ccccc21>>C[C@H](CO)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12",
        "output": "737"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1cc(F)cnc1Oc1cccc(SCC)c1.O.O.[Li+].[OH-]>>CCSc1cccc(Oc2ncc(F)cc2C(=O)O)c1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)[C@@H]1CCNC1.CN(Cc1cn2c(F)cccc2n1)C1CCCc2cccnc21>>CN(Cc1cn2c(N3CC[C@@H](N(C)C)C3)cccc2n1)C1CCCc2cccnc21",
        "output": "756"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.Cc1ccc(C(=O)O)cc1C(F)(F)F.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(C)c(C(F)(F)F)c1",
        "output": "415"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1nc(NCc2c(C)cc(NC(=O)OC(C)(C)C)nc2C)c2cn(Cc3ccc(Cn4cccn4)cc3)nc2n1.Cl.ClCCl>>COc1nc(NCc2c(C)cc(N)nc2C)c2cn(Cc3ccc(Cn4cccn4)cc3)nc2n1",
        "output": "885"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NCCCCN1CCC(n2nnc3ccccc32)CC1.O=C(Cl)C(=O)Cl.O=C(O)C=Cc1cccnc1>>O=C(C=Cc1cccnc1)NCCCCN1CCC(n2nnc3ccccc32)CC1",
        "output": "549"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "N#CC1CCN(C(=O)N2CC(C(=O)O)CC(c3ccc(OC(F)(F)F)cc3)C2)CC1.N=C(NO)c1ccccc1F>>N#CC1CCN(C(=O)N2CC(c3ccc(OC(F)(F)F)cc3)CC(c3nc(-c4ccccc4F)no3)C2)CC1",
        "output": "895"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(NC(=O)c2cc(N3CCN(C(=O)OC(C)(C)C)CC3)cc(S(F)(F)(F)(F)F)c2)cc1-n1ccn2nc(-c3cn[nH]c3)cc12.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(NC(=O)c2cc(N3CCNCC3)cc(S(F)(F)(F)(F)F)c2)cc1-n1ccn2nc(-c3cn[nH]c3)cc12",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cc(-n2ncnn2)ccc1N.ClI>>Cc1cc(-n2ncnn2)cc(I)c1N",
        "output": "466"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOP([O-])OCC.Cc1ccc(Oc2ccc(C#N)cc2)nc1.ClC(Cl)(Cl)Cl.O.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C([O-])O.O=C1CCC(=O)N1Br.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>N#Cc1ccc(Oc2ccc(CBr)cn2)cc1",
        "output": "625"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1cc(CCCC(C)C)[nH]n1.CO.[Na+].[OH-]>>CC(C)CCCc1cc(C(=O)O)n[nH]1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC1(C)CCCC(C)(C)N1.C[Si](C)(C)c1c(Br)ccc(F)c1F.O.O=C=O.[Li]CCCC>>C[Si](C)(C)c1c(Br)cc(C(=O)O)c(F)c1F",
        "output": "387"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(-c2nnc(C3CCN(Cc4ccc(-c5nc6cc[nH]c(=O)c6cc5-c5ccccc5)cc4)CC3)[nH]2)cn1.Cl>>O=c1[nH]ccc2nc(-c3ccc(CN4CCC(c5nnc(-c6ccc(O)nc6)[nH]5)CC4)cc3)c(-c3ccccc3)cc12",
        "output": "408"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(CC)CC.CCOC(=O)N1c2ccccc2C=CC1OCC.C[NH3+].Nc1nc(C(=O)O)c2ccccc2n1.[Cl-]>>CNC(=O)c1nc(N)nc2ccccc12",
        "output": "137"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(CC)CC.CCOCC.CN(C)C=O.COc1nc(Cl)ccc1[N+](=O)[O-].O>>COc1nc(N2CCN(C(=O)OC(C)(C)C)CC2)ccc1[N+](=O)[O-]",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(=O)(=O)Cl.Cc1nc(N)nc(N)c1-c1cc(N)ccc1Cl.c1ccncc1>>Cc1nc(N)nc(N)c1-c1cc(NS(C)(=O)=O)ccc1Cl",
        "output": "194"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.CCc1cc(CC)c2oc(C(=O)O)cc(=O)c2c1OC.Cl.O=C([O-])O.[Na+]>>CCc1cc(CC)c2oc(C(=O)O)cc(=O)c2c1O",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#CCO.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Fc1ccc(I)cc1.I[Cu]I>>OCC#Cc1ccc(F)cc1",
        "output": "664"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Cc1cc(NC(=O)CCl)c2nc(C)n(-c3ccc(Cl)cc3Cl)c2n1>>Cc1cc(NCCCl)c2nc(C)n(-c3ccc(Cl)cc3Cl)c2n1",
        "output": "112"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1csc(Br)n1.O.[Li+].[OH-]>>O=C(O)c1csc(Br)n1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.O=C(CCCCCCOc1ccc(OCc2ccccc2)cc1)c1nnc(COCc2ccccc2)o1.[Pd]>>O=C(CCCCCCOc1ccc(O)cc1)c1nnc(COCc2ccccc2)o1",
        "output": "23"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN.COC(=O)C(Br)CCBr>>CNC(=O)C(Br)CCBr",
        "output": "392"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCOC(=O)c1cn(-c2ccc(N3CCOC3=O)cc2)c(=O)n([C@@H]2CCc3c2cccc3C(F)(F)F)c1=O.Cl.O>>O=C(O)c1cn(-c2ccc(N3CCOC3=O)cc2)c(=O)n([C@@H]2CCc3c2cccc3C(F)(F)F)c1=O",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cl.ClCCl.NCCC1CC1.O.O=C(O)c1ccc(N2CCN(C(=O)c3ccccc3C(F)(F)F)CC2)nc1.On1nnc2ccccc21>>O=C(NCCC1CC1)c1ccc(N2CCN(C(=O)c3ccccc3C(F)(F)F)CC2)nc1",
        "output": "674"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(Cc1cccc(C=CC(=O)OCc2ccccc2)c1)NC(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CC(C)(N)Cc1cccc(C=CC(=O)OCc2ccccc2)c1",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.Cn1nnnc1-c1cccc(NC(=O)Oc2ccccc2)c1.N[C@@H]1CCCC[C@@]12CCCN(Cc1ccc(F)cc1)C2>>Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@@]23CCCN(Cc2ccc(F)cc2)C3)c1",
        "output": "488"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.COc1ccc(-c2ccc(Cc3ccccc3)s2)cc1>>Oc1ccc(-c2ccc(Cc3ccccc3)s2)cc1",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.CNCCC#N.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)nc1.[K+].[K+]>>CN(CCC#N)c1ccc([N+](=O)[O-])cn1",
        "output": "220"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.NCCN.NCCNc1ccc(-c2ncc[nH]2)c(-c2ccc(Cl)cc2Cl)n1.Nc1nc(Cl)ccc1[N+](=O)[O-]>>Nc1nc(NCCNc2ccc(-c3ncc[nH]3)c(-c3ccc(Cl)cc3Cl)n2)ccc1[N+](=O)[O-]",
        "output": "70"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Br.CC(=O)O.CN(c1nccc(-n2cnc3ccccc32)n1)C1CCN(C(=O)OCc2ccccc2)C1.ClCCl>>CN(c1nccc(-n2cnc3ccccc32)n1)C1CCNC1",
        "output": "428"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C=CC[C@]1(c2ccc(F)cc2)CCN([C@@H](C)c2ccc(-c3ccc(=O)[nH]c3)cc2)C(=O)O1.CI.[H-].[Na+]>>C=CC[C@]1(c2ccc(F)cc2)CCN([C@@H](C)c2ccc(-c3ccc(=O)n(C)c3)cc2)C(=O)O1",
        "output": "191"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CN1CCCC1=O.Cc1nc(CO)c(CNC(=O)c2cc(NC(=O)c3cc(F)c(F)cc3Cl)[nH]n2)o1.O>>CC(=O)OCc1nc(C)oc1CNC(=O)c1cc(NC(=O)c2cc(F)c(F)cc2Cl)[nH]n1",
        "output": "254"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1c(SCCN2CCc3ccccc3C2)ccnc1CO.O=S(Cl)Cl>>Cc1c(SCCN2CCc3ccccc3C2)ccnc1CCl",
        "output": "594"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N[C@@H](C)COc1ccc2nc(-c3ccc(O)c(F)c3)oc2c1.FC(F)(F)CCI>>CC(=O)N[C@@H](C)COc1ccc2nc(-c3ccc(OCCC(F)(F)F)c(F)c3)oc2c1",
        "output": "198"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2C(C)C.CN(C)C=O.FC(F)CBr.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCC(F)F)cc1CC2C(C)C",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(O)c(F)c1.c1ccc2c(c1)CC[C@@H]1NCCC[C@H]21>>O=C(c1ccc(O)c(F)c1)N1CCC[C@@H]2c3ccccc3CC[C@@H]21",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)[C@H](CNC(=O)c1cc(OCCCCC2CCN(C(=O)OC(C)(C)C)CC2)no1)NS(=O)(=O)c1ccccc1.O.O=S(=O)([O-])O.[Li]O.[Na+]>>CC(C)(C)OC(=O)N1CCC(CCCCOc2cc(C(=O)NC[C@H](NS(=O)(=O)c3ccccc3)C(=O)O)on2)CC1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Br[Ni]Br.C1CCOC1.CO.O=[N+]([O-])c1ccc(CNc2ncccn2)cc1.[BH4-].[Na+]>>Nc1ccc(CNc2ncccn2)cc1",
        "output": "507"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)Br.CCOC(=O)c1c(-c2ccc(Cl)cc2)oc2ccc(O)cc12.CN1CCCC1=O.O.O=C([O-])[O-].[Cs+].[Cs+].[NH4+]>>CCOC(=O)c1c(-c2ccc(Cl)cc2)oc2ccc(OC(C)C)cc12",
        "output": "153"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COC(=O)c1cc2ccc(OCc3ccccc3)cc2oc1=O.Cl.O.[Na+].[OH-]>>O=C(O)c1cc2ccc(OCc3ccccc3)cc2oc1=O",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1ccc2c(C(=O)NCc3cc(F)cc(F)c3)c(C(C)C)n(Cc3ccccn3)c2c1.O.[Na+].[OH-]>>CC(C)c1c(C(=O)NCc2cc(F)cc(F)c2)c2ccc(C(=O)O)cc2n1Cc1ccccn1",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCC(C)COc1ccccc1OCC(C)CC.Cc1ccccc1.O.O=C1CCC(=O)N1Br>>CCC(C)COc1ccc(Br)cc1OCC(C)CC",
        "output": "4"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)C(CCC(=O)O)NC(=O)OC(C)(C)C.COC[C@@H]1CCCN1.ClCCCl.ClCCl.O.On1nnc2ccccc21>>COC[C@@H]1CCCN1C(=O)CCC(NC(=O)OC(C)(C)C)C(=O)OC",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=CC(=O)Cl.CO.NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O.[K+].[OH-]>>C=CC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO",
        "output": "298"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)CCO.CC(C)CCOc1cc(Cl)nc(-c2ccccc2)n1.CC(C)c1nc(Cl)cc(Cl)n1.CCCCC(CC)CO.Clc1cc(Cl)nc(-c2ccccc2)n1>>CCCCC(CC)COc1cc(Cl)nc(C(C)C)n1",
        "output": "653"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COCCOCCO.COc1ccc2nc(Cl)nc(C)c2c1.Cl[Pd]Cl.O.O.O=C(O)c1ccc(B(O)O)cc1.O=C([O-])[O-].[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1ccc2nc(-c3ccc(C(=O)O)cc3)nc(C)c2c1",
        "output": "874"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCN1C(=O)CCCc2cc(N)c(OC)cc21.CC[NH+](CC)CC.CC[NH+](CC)CC.CS(=O)(=O)N[C@@H]1CCCC[C@H]1Nc1nc(Cl)ncc1Cl.Cl.O=C([O-])[O-]>>CCN1C(=O)CCCc2cc(Nc3ncc(Cl)c(N[C@@H]4CCCC[C@H]4NS(C)(=O)=O)n3)c(OC)cc21",
        "output": "808"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCCCCCCCc1cccnc1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>OCCCCCCCc1cccnc1",
        "output": "708"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Br.CCCCc1nc2ccccn2c(=O)c1Br.CCCc1nc2ccccn2c(=O)c1Br.COc1ccc(B(O)O)cc1.OB(O)c1ccc(Cl)cc1>>CCCc1nc2ccccn2c(=O)c1-c1ccc(Cl)cc1",
        "output": "871"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)CC(c2ccccc2C2=CCN(C(=O)OC(C)(C)C)CC2)CC(C)(C)C1.ClCCl.O=C(O)C(F)(F)F>>CC1(C)CC(c2ccccc2C2=CCNCC2)CC(C)(C)C1",
        "output": "800"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CNC(C)(C)C.COc1cc2c(cc1C=C(C)C)-c1c(c(C(=O)O)nn1-c1cccs1)CO2.ClCCl.F[P-](F)(F)(F)(F)F>>COc1cc2c(cc1C=C(C)C)-c1c(c(C(=O)N(C)C(C)(C)C)nn1-c1cccs1)CO2",
        "output": "663"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)C(=Cc1ccccc1)Oc1ccccc1O.CC(C)=O.CCN(CC)CCCl.[Na]>>CCN(CC)CCOc1ccccc1OC(=Cc1ccccc1)C(C)=O",
        "output": "74"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cncc(-c2ccc(S(=O)(=O)NC3CCCCc4c(OCC(=O)OC(C)(C)C)cccc43)cc2)c1.[Na+].[OH-]>>Cc1cncc(-c2ccc(S(=O)(=O)NC3CCCCc4c(OCC(=O)O)cccc43)cc2)c1",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.Cc1c[nH]c2c1C(=O)CC(C)(C)C2.N#Cc1c(F)cc(Br)cc1N[C@H]1CCC[C@@H]1OCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>Cc1cn(-c2cc(F)c(C#N)c(N[C@H]3CCC[C@@H]3OCc3ccccc3)c2)c2c1C(=O)CC(C)(C)C2",
        "output": "349"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCC.CO.NC(=O)C(N)C1CC1.O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1>>NC(=O)C(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1",
        "output": "738"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1cc([N+](=O)[O-])cn1C(C)C.[Na+].[OH-]>>CC(C)n1cc([N+](=O)[O-])cc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1.ClCCl.O=C(O)C(F)(F)F>>Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCCNC1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(Oc1cncc(Cl)c1)C(=O)OC.O.[Na+].[OH-]>>CCC(Oc1cncc(Cl)c1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(C)cc(OCCO[Si](C)(C)C(C)(C)C)c1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>Cc1cc(CBr)cc(OCCO[Si](C)(C)C(C)(C)C)c1",
        "output": "29"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.C[C@@H]1C[C@@H](O)CC(C)(C)C1=O.c1ccncc1>>CC(=O)O[C@@H]1C[C@@H](C)C(=O)C(C)(C)C1",
        "output": "254"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CN1CCN(c2cccc3c2C[C@H](N)CO3)CC1.O=C(O)c1ccc(N2CCN(Cc3ccccc3)CC2)cc1.O=C(n1ccnc1)n1ccnc1>>CN1CCN(c2cccc3c2C[C@H](NC(=O)c2ccc(N4CCN(Cc5ccccc5)CC4)cc2)CO3)CC1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl.COC(=O)[C@H](CCC(=O)O)NC(=O)OCc1ccccc1.Cl.ClCCl.On1nnc2ccccc21>>CCOC(=O)C1=C(COCCNC(=O)CC[C@H](NC(=O)OCc2ccccc2)C(=O)OC)NC(C)=C(C(=O)OC)C1c1ccccc1Cl",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc2ncnc(Cl)c2cc1OC.Fc1cc(C2CNCCN2)c(Cl)cc1Cl>>COc1cc2ncnc(N3CCNC(c4cc(F)c(Cl)cc4Cl)C3)c2cc1OC",
        "output": "296"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1ccccc1-c1ccc(-c2ccc(C(F)(F)F)cc2)o1.Cl.O.[Na+].[OH-]>>O=C(O)c1ccccc1-c1ccc(-c2ccc(C(F)(F)F)cc2)o1",
        "output": "5"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.NC(=O)c1cnc(Oc2ccc(C=O)cc2F)cn1.NCCC1CCOCC1.[BH4-].[Na+]>>NC(=O)c1cnc(Oc2ccc(CNCCC3CCOCC3)cc2F)cn1",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.CC(N)Cc1ccccc1.O.O=S(=O)(O)O.[Na+].[OH-]>>CC(=O)NC(C)Cc1ccccc1",
        "output": "339"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)n1c(-c2cc(F)ccc2C#N)nc2cc(-c3cnc(N)nc3)ccc21.CCO.NO>>CC(C)(C)n1c(-c2cc(F)ccc2C(=N)NO)nc2cc(-c3cnc(N)nc3)ccc21",
        "output": "854"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.COC(=O)c1ccc2c(c1)Nc1nccnc1S2.Cc1ccccc1.ClCCl.[H-]>>OCc1ccc2c(c1)Nc1nccnc1S2",
        "output": "444"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(O)c(Br)c1.O=C(CBr)c1ccccc1.O=C([O-])[O-].[K+].[K+].c1ccccc1>>Cc1ccc(OCC(=O)c2ccccc2)c(Br)c1",
        "output": "221"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.O=Cc1ccc(F)c(Br)c1.[BH4-].[Na+]>>OCc1ccc(F)c(Br)c1",
        "output": "356"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cncc(SC)c1.Cl.Cl.[Cl-].[NH4+].c1cc[nH+]cc1>>CSc1cncc(O)c1",
        "output": "424"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Nc1ccccc1NS(=O)(=O)Cc1ccccc1.O=C=Nc1ccccc1Br>>O=C(Nc1ccccc1Br)Nc1ccccc1NS(=O)(=O)Cc1ccccc1",
        "output": "473"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.COC(=O)c1ccc(CO)cc1C.Oc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1ccc(COc2ccccc2)cc1C",
        "output": "550"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.Cn1cc(C2CCN(C(=O)OC(C)(C)C)CC2)c2cc(N)ccc21.O.O=S(=O)(Cl)c1ccc(F)cc1.c1ccncc1>>Cn1cc(C2CCN(C(=O)OC(C)(C)C)CC2)c2cc(NS(=O)(=O)c3ccc(F)cc3)ccc21",
        "output": "68"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CNCc1ccccc1.O=C(O)c1ccc2cc(O)ccc2c1>>CN(Cc1ccccc1)C(=O)c1ccc2cc(O)ccc2c1",
        "output": "794"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCC(Oc1cccc(C#N)c1)C(=O)Nc1ccc(-c2ccccc2S(C)(=O)=O)cc1.CCN(CC)CC.CO.Cl.O.[Cl-].[NH3+]O>>CCCC(Oc1cccc(C(=N)NO)c1)C(=O)Nc1ccc(-c2ccccc2S(C)(=O)=O)cc1",
        "output": "854"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)O)c3ccccc3n2)CC1.CN(C)C=O.Cl.ClCCCl.O.O=C(NC1CC1)[C@@H]1CCCN1.Oc1c(F)c(F)c(F)c(F)c1F>>CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NC3CC3)c3ccccc3n2)CC1",
        "output": "297"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1ccc(OC)c2nc(N)sc12.O=C(Cl)c1ccc(F)cc1>>COC(=O)c1ccc(OC)c2nc(NC(=O)c3ccc(F)cc3)sc12",
        "output": "673"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCC2=NCCCN2CC1.CC(C)(C)[Si](C)(C)Cl.ClCCl.NCCCO>>CC(C)(C)[Si](C)(C)OCCCN",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](OC(C)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CN(C)C=O.ClCCl.O=C([O-])[O-].[K+].[K+]>>C=C(C)[C@@H]1CC[C@]2(C(=O)OCc3ccccc3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](OC(C)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12",
        "output": "403"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C)CC.CN1CCNCC1.Cc1ccc(Oc2ccnc(Nc3cccc(CCl)c3)c2)c(C)n1.ClCCl>>Cc1ccc(Oc2ccnc(Nc3cccc(CN4CCN(C)CC4)c3)c2)c(C)n1",
        "output": "156"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1cccc(OCC(=O)C23CC4CC(CC(C4)C2)C3)c1.O.[Li+].[OH-]>>O=C(O)c1cccc(OCC(=O)C23CC4CC(CC(C4)C2)C3)c1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCc1cc(Cl)c2oc(Cc3ccc(OC)cc3)c(C)c2c1O.CCN(CC)CC.CCOC(=O)Cl>>CCCc1cc(Cl)c2oc(Cc3ccc(OC)cc3)c(C)c2c1OC(=O)OCC",
        "output": "261"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C/C=C/[C@H](OC)[C@H](C)[C@@H](OC)[C@@H](C)CO.CC(C)(C)C(=O)Cl.c1ccncc1>>C/C=C/[C@H](OC)[C@H](C)[C@@H](OC)[C@@H](C)COC(=O)C(C)(C)C",
        "output": "126"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)c1cc2cccc(OC)c2s1.CO.[Na+].[OH-]>>COc1cccc2cc(C(=O)O)sc12",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.CC1(C)CSc2ccccc2SC1.ClCCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)c1ccc2c(c1)SCC(C)(C)CS2",
        "output": "31"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.NC1COc2cc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)ccc2C1O.O>>CC(C)(C)OC(=O)NC1COc2cc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)ccc2C1O",
        "output": "631"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CN(C)C=O.CN1CCCC1.Cl.Cl.NC1CNC1.Nc1nc(-n2cc(C(=O)O)c(=O)c3cc(F)c(F)c(Br)c32)c(F)cc1F>>Nc1nc(-n2cc(C(=O)O)c(=O)c3cc(F)c(N4CC(N)C4)c(Br)c32)c(F)cc1F",
        "output": "676"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC=O.COc1nc(/C(=C/C2CCCC2)c2ccc(SC3CNC3)cc2)ccc1C.ClC(Cl)Cl.O.[Na+]>>CCN1CC(Sc2ccc(/C(=C\\C3CCCC3)c3ccc(C)c(OC)n3)cc2)C1",
        "output": "484"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1=CCC=CC1.CO.Cc1cc(-c2nc3[nH]nc(-c4ccco4)c3c(-c3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cc3)c2C#N)ccc1OCc1ccccc1.ClCCl.[Pd]>>Cc1cc(-c2nc3[nH]nc(-c4ccco4)c3c(-c3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cc3)c2C#N)ccc1O",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cccc(Cl)n1.O=S(=O)(O)O.O=[N+]([O-])O>>COc1ccc([N+](=O)[O-])c(Cl)n1",
        "output": "328"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.NCCCn1ccnc1.O=C[C@@H]1C[C@H]1CN1CCN(c2csc3cc(C(F)(F)F)ccc23)CC1.[BH4-]>>FC(F)(F)c1ccc2c(N3CCN(C[C@@H]4C[C@H]4CNCCCn4ccnc4)CC3)csc2c1",
        "output": "426"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.CCO.CCOC(C)=O.CN(C)C1CCN(C(=O)Nc2cc(Oc3ccc(N)cc3F)ncn2)CC1.Cc1ccccc1.O=C(Cc1ccc(F)cc1)N=C=S.O=C([O-])O.[Na+]>>CN(C)C1CCN(C(=O)Nc2cc(Oc3ccc(NC(=S)NC(=O)Cc4ccc(F)cc4)cc3F)ncn2)CC1",
        "output": "961"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.ClCCl.O.c1ccc2[nH]ccc2c1>>CC(C)(C)OC(=O)n1ccc2ccccc21",
        "output": "748"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.N#Cc1ccc(CBr)cc1.O=C([O-])[O-].Oc1cccc(O)c1.[K+].[K+]>>N#Cc1ccc(COc2cccc(O)c2)cc1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cn1cccc1CCN.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>Cn1cccc1CCNS(=O)(=O)c1ccc([N+](=O)[O-])cc1",
        "output": "43"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCc1ccc(C=O)[nH]1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>CCCc1[nH]c(C=O)cc1Br",
        "output": "796"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cl.N#Cc1ccnc(-n2nc(-c3ccc(Cl)cc3)cc2O)c1.O.[Na+].[OH-]>>O=C(O)c1ccnc(-n2nc(-c3ccc(Cl)cc3)cc2O)c1",
        "output": "445"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.CCOC(C)=O.N#CCBr.O=C([O-])[O-].Oc1cc(C(F)(F)F)nc2ccc(-c3cc4ccccc4o3)cc12.[Cs+].[Cs+]>>N#CCOc1cc(C(F)(F)F)nc2ccc(-c3cc4ccccc4o3)cc12",
        "output": "802"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCS(=O)(=O)Cl.CN(C)C=O.CN(C)c1ccncc1.NC(=O)c1cc(-c2ccccc2)nc2c(C3CCNCC3)c[nH]c12>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4ccccc4)nc23)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(NC(=O)OC(C)(C)C)CCN(c2ccc(S(C)(=O)=O)cn2)CC1.ClCCl.O=C(O)C(F)(F)F>>CC1(N)CCN(c2ccc(S(C)(=O)=O)cn2)CC1",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NCC(c1ccc(C(F)(F)F)nc1)N1CCC(F)(F)CC1.O=C(O)c1cccc(Cl)c1Cl>>O=C(NCC(c1ccc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1cccc(Cl)c1Cl",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOP(=O)(COCCNO)OCC.Cc1cc(C)nc(C)c1.ClCCl>>O=P(O)(O)COCCNO",
        "output": "535"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC#N.CC(C)(C)[O-].CN1CCCC1=O.COc1ccccc1O.O=C(NCc1ccc(C(F)(F)F)cc1)c1cnc(Cl)nc1N1CCCC1.[K+]>>COc1ccccc1Oc1ncc(C(=O)NCc2ccc(C(F)(F)F)cc2)c(N2CCCC2)n1",
        "output": "542"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)C1(CCCCCl)CC1.CCC(C)=O.CCOCC.[I-].[Na+]>>CC(C)(C)OC(=O)C1(CCCCI)CC1",
        "output": "97"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.Cl.O=C=O.OCCCc1cccc(Br)c1.[Li]CCCC>>O=C(O)c1cccc(CCCO)c1",
        "output": "654"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)n1c(=O)c(-c2ccc(F)c([N+](=O)[O-])c2)cc2cnc(N)nc21.CCOC(C)=O.CO.[Pd]>>CC(C)n1c(=O)c(-c2ccc(F)c(N)c2)cc2cnc(N)nc21",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCC1CC1.CN(C)C=O.O.O=C([O-])[O-].O=Cc1ccc(OC(F)F)c(O)c1.[K+].[K+]>>O=Cc1ccc(OC(F)F)c(OCC2CC2)c1",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)[C@H]1CN(CC#Cc2cccs2)CC[C@H]1CCC(=O)c1ccnc2ccc(OC)cc12.O.[BH4-].[Na+]>>COC(=O)[C@H]1CN(CC#Cc2cccs2)CC[C@H]1CCC(O)c1ccnc2ccc(OC)cc12",
        "output": "24"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)n1ncc2cc(N)ccc21.CCN(CC)CC.CCOC(C)=O.O=C(Cl)Oc1ccccc1>>CC(C)(C)OC(=O)n1ncc2cc(NC(=O)Oc3ccccc3)ccc21",
        "output": "102"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC#N.COc1nc(Cl)ncc1Br.Cc1cc(C)cc(N)c1.Cl>>COc1nc(Nc2cc(C)cc(C)c2)ncc1Br",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCC.CCN(CC)CC.CS(C)=O.ClCCl.O.OC(CCc1ccc(Cl)cc1)Cn1ccnc1>>O=C(CCc1ccc(Cl)cc1)Cn1ccnc1",
        "output": "87"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN1C(=O)N(c2cc(OC)cc(OC)c2)Cc2cnc(S(C)=O)nc21.CN1CCN(CCCCCN)CC1>>CCN1C(=O)N(c2cc(OC)cc(OC)c2)Cc2cnc(NCCCCCN3CCN(C)CC3)nc21",
        "output": "666"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.COC(=O)CC1CN(C(=O)OC(C)(C)C)CCN1.Cc1cc(Cl)c2ccccc2n1.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>COC(=O)CC1CN(C(=O)OC(C)(C)C)CCN1c1cc(C)nc2ccccc12",
        "output": "398"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.Cc1c(O)ccc(Br)c1C.Cc1cccc(-n2nnn(C)c2=O)c1CBr.O.O=C([O-])[O-].[K+].[K+]>>Cc1cccc(-n2nnn(C)c2=O)c1COc1ccc(Br)c(C)c1C",
        "output": "127"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COc1cc(OC)c2c(C)c(CCOS(C)(=O)=O)c(=O)oc2c1.COc1ccccc1N1CCNCC1>>COc1cc(OC)c2c(C)c(CCN3CCN(c4ccccc4OC)CC3)c(=O)oc2c1",
        "output": "496"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.COC(=O)c1ccc(CN2CCCNCC2)cc1.O=C(CCl)Nc1ccc(Oc2ccccc2)cc1.O=C([O-])O.[Na+]>>COC(=O)c1ccc(CN2CCCN(CC(=O)Nc3ccc(Oc4ccccc4)cc3)CC2)cc1",
        "output": "340"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(NC(=O)c2cc(N3CCOCC3)cc(C(F)(F)F)c2)cc1N.O=C(Cl)c1ccc(Cl)nc1>>Cc1ccc(NC(=O)c2cc(N3CCOCC3)cc(C(F)(F)F)c2)cc1NC(=O)c1ccc(Cl)nc1",
        "output": "642"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCCC1=O.C[C@H](Nc1ncnc2[nH]cnc12)c1cc2cccc(C=O)c2c(=O)n1-c1ccccc1.Cl.NO>>C[C@H](Nc1ncnc2[nH]cnc12)c1cc2cccc(C#N)c2c(=O)n1-c1ccccc1",
        "output": "453"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.OC1CCC2(CC1)OCCO2.c1ccncc1>>Cc1ccc(S(=O)(=O)OC2CCC3(CC2)OCCO3)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCC2=NCCCN2CC1.COCCOC.N#Cc1c(Cl)nc(N)nc1-c1ccccc1.Oc1ccccc1>>N#Cc1c(Oc2ccccc2)nc(N)nc1-c1ccccc1",
        "output": "668"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1c(-c2ccccc2OC)csc1N1C(=O)c2ccccc2C1=O.CO.Cl.O.[Na+].[OH-]>>COc1ccccc1-c1csc(N2C(=O)c3ccccc3C2=O)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)c1cc2c(OC(C)=O)cccc2n1Cc1ccc(Cl)c(Cl)c1.C[O-].Cl.[Na+]>>COC(=O)c1cc2c(O)cccc2n1Cc1ccc(Cl)c(Cl)c1",
        "output": "22"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.COc1ccc(C=O)c(O)c1Br.O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(C=O)c(OC)c1Br",
        "output": "62"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(O)c1ccc(-c2cc(C(N)=O)c(Nc3cccc(C=O)n3)s2)c(F)c1.O=C1NCC2(CCNCC2)O1>>CC(C)(O)c1ccc(-c2cc(C(N)=O)c(Nc3cccc(CN4CCC5(CC4)CNC(=O)O5)n3)s2)c(F)c1",
        "output": "829"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.Fc1cc(Cl)cc(Br)c1.O=C([O-])[O-].Oc1cccnc1.[K+].[K+]>>Clc1cc(Br)cc(Oc2cccnc2)c1",
        "output": "845"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)Nc1cnc(-c2ccncc2)s1.ClCCl.O=C(O)C(F)(F)F>>N[C@@H](Cc1ccc(F)cc1)C(=O)Nc1cnc(-c2ccncc2)s1",
        "output": "431"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCCCCCCCCCCC(O)c1coc([Si](C)(C)C)c1.CCOCC.CI.[H-].[Na+]>>CCCCCCCCCCCCC(OC)c1coc([Si](C)(C)C)c1",
        "output": "140"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)OC[C@@H](COc2ccc(CCCC(N)C#N)cc2)O1.CO.N.[H][H].[Ni]>>CC1(C)OC[C@@H](COc2ccc(CCCC(N)CN)cc2)O1",
        "output": "246"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CC(C)N1CCN(C(=O)c2ccc(-c3cncc(Br)c3)cc2)CC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COCCOC.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)N1CCN(C(=O)c2ccc(-c3cncc(B4OC(C)(C)C(C)(C)O4)c3)cc2)CC1",
        "output": "943"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.ClC(Cl)Cl.Clc1nc2nc(C3CC3)nc(Cl)c2s1.O=C(NCc1ccc(OC(F)(F)F)cc1)[C@H]1CNCCN1S(=O)(=O)c1ccc(OC(F)(F)F)cc1>>O=C(NCc1ccc(OC(F)(F)F)cc1)[C@H]1CN(c2nc3nc(C4CC4)nc(Cl)c3s2)CCN1S(=O)(=O)c1ccc(OC(F)(F)F)cc1",
        "output": "558"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)N1CCC(Oc2ccc(C3CCNCC3)cc2)CC1.ClCCl.N#Cc1ccc(C(=O)O)cc1.O.On1nnc2ccccc21>>CC(C)N1CCC(Oc2ccc(C3CCN(C(=O)c4ccc(C#N)cc4)CC3)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].O=[N+]([O-])c1ccc(Cl)cc1C(O)c1ccc(Cl)nc1.c1cc[nH+]cc1.c1cc[nH+]cc1>>O=C(c1ccc(Cl)nc1)c1cc(Cl)ccc1[N+](=O)[O-]",
        "output": "852"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCn1c(=O)c([N+](=O)[O-])c(C)n(CCC(C)C)c1=O.[Br-].[K+]>>CCCCn1c(=O)c(N)c(C)n(CCC(C)C)c1=O",
        "output": "660"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCO.O=C1CC2CSCC(C1)N2>>CC(C)(C)OC(=O)N1C2CSCC1CC(=O)C2",
        "output": "694"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.Cc1nc2c([N+](=O)[O-])ccc(C#N)c2o1.[Fe]>>Cc1nc2c(N)ccc(C#N)c2o1",
        "output": "269"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCc2c(nc(-c3ccc(F)cc3)n(NCc3ccc(Br)cc3)c2=O)C1.CCOC(C)=O.ClCCl.O=C(O)C(F)(F)F>>O=c1c2c(nc(-c3ccc(F)cc3)n1NCc1ccc(Br)cc1)CNCC2",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)OCc1c(-c2cc(Nc3cc4n(n3)CC(C)(C)OC4)c(=O)n(C)c2)ccnc1-n1ncc2cc(C(C)(C)C)cc(F)c2c1=O.CC(C)O.O.[Li+].[OH-]>>Cn1cc(-c2ccnc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(Nc2cc3n(n2)CC(C)(C)OC3)c1=O",
        "output": "348"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCBr.COC(=O)c1ccc(Oc2cccc(O)c2)cc1>>C=CCOc1cccc(Oc2ccc(C(=O)OC)cc2)c1",
        "output": "77"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COCCBr.Cc1c(O)cccc1Br>>COCCOc1cccc(Br)c1C",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(CCN1CCNCC1)c1ccccc1.CCOC(C)=O.CN(C)C=O.O=C(O)C1CSC(c2cccnc2)N1.On1nnc2ccccc21>>CC(C)(CCN1CCN(C(=O)C2CSC(c3cccnc3)N2)CC1)c1ccccc1",
        "output": "685"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCCOC.O.O=C([O-])[O-].O=[N+]([O-])c1ccccc1Br.OB(O)c1ccccc1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=[N+]([O-])c1ccccc1-c1ccccc1",
        "output": "837"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O=Cc1cccc(O)c1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1cccc(C=O)c1",
        "output": "746"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CCCCCCCCCCBr.CCOC(C)=O.COCCOCCOCCO.[Na+].[OH-]>>C=CCCCCCCCCCOCCOCCOCCOC",
        "output": "95"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccc(NC(=O)C(C)C)cc1C1CCN(CCCN)CC1.O=C(O)C(O)(c1ccccc1Cl)c1ccccc1Cl>>Cc1ccc(NC(=O)C(C)C)cc1C1CCN(CCCNC(=O)C(O)(c2ccccc2Cl)c2ccccc2Cl)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(=O)CN(Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)nc1)C1CNC1.CN(C)C=O.COCCOCCOCC(=O)O.Cl.O.On1nnc2ccccc21>>CCOC(=O)CN(Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)nc1)C1CN(C(=O)COCCOCCOC)C1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C(C)Cc1cc(F)c(O)c(F)c1.CN(C)C=O.ClCc1ccccc1.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C(C)Cc1cc(F)c(OCc2ccccc2)c(F)c1",
        "output": "49"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NC1(C#N)CCCC1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(C)OC(=O)NC1(CN)CCCC1",
        "output": "246"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccccc1N.ClC(Cl)Cl.Nc1cccc(Cl)c1C(=O)O.O=S(Cl)Cl.c1ccccc1>>COc1ccccc1NC(=O)c1c(N)cccc1Cl",
        "output": "50"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOCC.NCc1ccccn1.O.O=C(Cl)c1cc(OCc2ccccc2)ccc1OCC(F)(F)F.O=C([O-])[O-].[Na+].[Na+].c1ccccc1>>O=C(NCc1ccccn1)c1cc(OCc2ccccc2)ccc1OCC(F)(F)F",
        "output": "271"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccccc1.Nc1cccc(C(F)(F)F)c1.O=Cc1ccccc1F>>Fc1ccccc1C=Nc1cccc(C(F)(F)F)c1",
        "output": "329"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCc1nc2cccc(CO)c2n1Cc1ccccc1Cl.ClCCl.O=S(Cl)Cl>>CCCCc1nc2cccc(CCl)c2n1Cc1ccccc1Cl",
        "output": "477"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC1Oc2c(C(C)C)cccc2N(CCC(=O)OC)C1=O.CO.[Na+].[OH-]>>CCC1Oc2c(C(C)C)cccc2N(CCC(=O)O)C1=O",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC=O.ClCCl.FC(F)(F)c1nnc(N2CCNCC2)cc1-c1ccccc1.[Na+]>>CCN1CCN(c2cc(-c3ccccc3)c(C(F)(F)F)nn2)CC1",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C(=O)OC(C)(C)C)C1CCC(Oc2ncnc3sc4c(c23)[C@@H](CC(=O)O)CC4)CC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNC(=O)CN.Cl.F[P-](F)(F)(F)(F)F.O>>CNC(=O)CNC(=O)C[C@H]1CCc2sc3ncnc(OC4CCC(N(C)C(=O)OC(C)(C)C)CC4)c3c21",
        "output": "133"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.Clc1cncc(Cl)n1.NCC(O)CN1CCc2ccccc2C1>>OC(CNc1cncc(Cl)n1)CN1CCc2ccccc2C1",
        "output": "148"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CCCCCCCCCCO.II.c1c[nH]cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C=CCCCCCCCCCI",
        "output": "670"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.O=[N+]([O-])c1ccc2c(c1)CNCCC2>>CC(C)(C)OC(=O)N1CCCc2ccc([N+](=O)[O-])cc2C1",
        "output": "867"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1ccc(-c2nocc2C(=O)O)cc1.F[B-](F)(F)F.c1cncc(C2CCNC2)c1>>Cc1ccc(-c2nocc2C(=O)N2CCC(c3cccnc3)C2)cc1",
        "output": "975"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.NS(=O)(=O)c1cnc(Cl)c(Cl)c1.OCC1(F)CCC2(CC1)OCCO2.[Cl-].[H-].[NH4+].[Na+]>>NS(=O)(=O)c1cnc(OCC2(F)CCC3(CC2)OCCO3)c(Cl)c1",
        "output": "433"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc(C(=O)O)cc(CC(C)C)n1.Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@H]3C[C@H]3[C@H]2CN)c1>>Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@H]3C[C@H]3[C@H]2CNC(=O)c2cc(C)nc(CC(C)C)c2)c1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COc1cc(CCN2CCN(CCCc3ccccc3)CC2)ccc1OCc1ccccc1.[Pd]>>COc1cc(CCN2CCN(CCCc3ccccc3)CC2)ccc1O",
        "output": "23"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCc1cc([N+](=O)[O-])c(=O)[nH]c1C.CO.[Pd]>>CCc1cc(N)c(=O)[nH]c1C",
        "output": "269"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1c(Br)ccc(-c2cnc(N)cn2)c1F.OB(O)c1ccc(C(F)(F)F)cc1>>COc1c(-c2ccc(C(F)(F)F)cc2)ccc(-c2cnc(N)cn2)c1F",
        "output": "837"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC(=O)N1CCNCC1.CCN(CC)CC.COCCOc1nc(Cl)ccc1[N+](=O)[O-]>>COCCOc1nc(N2CCN(C(C)=O)CC2)ccc1[N+](=O)[O-]",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCN1.CC(C)(C)OC(=O)N1CCC(Oc2ccc(F)cc2Br)CC1.CC(C)(C)[O-].Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(F)cc2N2CCOCC2)CC1",
        "output": "294"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc(C)c(S(=O)(=O)Cl)c(C)c1.Cc1ccc2n1CCNC2CO.ClCCl>>COc1cc(C)c(S(=O)(=O)N2CCn3c(C)ccc3C2CO)c(C)c1",
        "output": "99"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CCOC(C)=O.CN(C)C=O.CO.COc1cc2c(Oc3ccc(NC(=O)C(=O)NCCc4ccccc4)cc3F)ccnc2cc1OCc1ccccc1.ClCCl.[OH-].[OH-].[Pd+2]>>COc1cc2c(Oc3ccc(NC(=O)C(=O)NCCc4ccccc4)cc3F)ccnc2cc1O",
        "output": "23"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)c1ccc(C(=O)O)cc1.NCCC(c1ccc(F)cc1)c1ccc(F)cc1>>CS(=O)(=O)c1ccc(C(=O)NCCC(c2ccc(F)cc2)c2ccc(F)cc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)CC(c2ccc(N)cn2)CC(C)(C)O1.ClCCl.O=C([O-])[O-].O=C1CCC(=O)N1Br.[Na+].[Na+]>>CC1(C)CC(c2ccc(N)c(Br)n2)CC(C)(C)O1",
        "output": "779"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(CCc1ccc(-c2ccccc2O)cc1)(C(=O)NOC1CCCCO1)S(C)(=O)=O.CO.Cl.ClCCl>>CC(CCc1ccc(-c2ccccc2O)cc1)(C(=O)NO)S(C)(=O)=O",
        "output": "915"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1ncccc1OCC12CNCC1C2.Cl.Cl.O=C(O)[C@@H]1CC[C@@H](C(F)(F)F)CC1.O=C(O)c1cc2ccccc2[nH]1>>CCOC(=O)c1ncccc1OCC12CC1CN(C(=O)[C@@H]1CC[C@@H](C(F)(F)F)CC1)C2",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(O)C1CCN(CCC(F)(F)F)CC1.O=S(Cl)Cl>>O=C(Cl)C1CCN(CCC(F)(F)F)CC1",
        "output": "53"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1=COCCC1.CCOCC.Cc1ccccc1S(=O)(=O)O.OCc1cc(CBr)oc1C(F)(F)F>>FC(F)(F)c1oc(CBr)cc1COC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.COc1cc(O)c2cc(-c3cn4nc([C@H](C)F)sc4n3)oc2c1.ClCCl.OCc1cccc(-c2cncnc2)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccccc1>>COc1cc(OCc2cccc(-c3cncnc3)c2)c2cc(-c3cn4nc([C@H](C)F)sc4n3)oc2c1",
        "output": "347"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COc1ccc(-c2ccn(CC[C@](C)(C(=O)NOC3CCCCO3)S(C)(=O)=O)c(=O)c2)c(F)c1.Cc1ccc(S(=O)(=O)O)cc1.O.c1cc[nH+]cc1>>COc1ccc(-c2ccn(CC[C@](C)(C(=O)NO)S(C)(=O)=O)c(=O)c2)c(F)c1",
        "output": "915"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCn1c(SC(CC)C(=O)OCC)nc2c1c(=O)[nH]c(=O)n2C.CO.N>>CCCCn1c(SC(CC)C(N)=O)nc2c1c(=O)[nH]c(=O)n2C",
        "output": "163"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1[C@H](N)C(=O)N1S(=O)(=O)O.O=CNc1nc(CC(=O)O)cs1.[Na+].[OH-]>>CC1[C@H](NC(=O)Cc2csc(NC=O)n2)C(=O)N1S(=O)(=O)O",
        "output": "133"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)Oc1ccc(O)cc1.CN(C(=O)Cl)c1ccccc1.ClCCl>>CN(C(=O)Oc1ccc(OC(C)(C)C)cc1)c1ccccc1",
        "output": "425"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.ClCCl.N#Cc1ccc2cc(Br)ccc2c1.[K+]>>CC1(C)OB(c2ccc3cc(C#N)ccc3c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)N=C=O.CC(C)(C)[Si](C)(C)OCCCCCCNC1CCCCC1>>CC(C)(C)NC(=O)N(CCCCCCO[Si](C)(C)C(C)(C)C)C1CCCCC1",
        "output": "437"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc(C(=O)NC2CCCCN(C(=O)OC(C)(C)C)C2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CCC(=O)N2C.ClCCl.O=C(O)C(F)(F)F>>COc1cc(C(=O)NC2CCCCNC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CCC(=O)N2C",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCc2ccc(-c3noc(-c4ccc(OC(CF)CF)c(C#N)c4)n3)cc2CC1.ClCCl.O=C(O)C(F)(F)F>>N#Cc1cc(-c2nc(-c3ccc4c(c3)CCNCC4)no2)ccc1OC(CF)CF",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Clc1cc(Br)cc(-c2nc(-c3ccccc3)nc(-c3ccccc3)n2)c1.O.OB(O)c1cc2ccccc2c2ccccc12.[Na+].[OH-].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Clc1cc(-c2nc(-c3ccccc3)nc(-c3ccccc3)n2)cc(-c2cc3ccccc3c3ccccc23)c1",
        "output": "837"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(C(=O)Cl)cc1.Nc1nc(N)c2c(N3CCNCC3)cccc2n1>>Cc1ccc(C(=O)N2CCN(c3cccc4nc(N)nc(N)c34)CC2)cc1",
        "output": "201"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br.CC(=O)O.COc1ccc(C(=O)O)cc1SC.O.O=C([O-])[O-].[Na+].[Na+]>>CSc1cc(C(=O)O)ccc1O",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)NC(Cc1ccc(C(=O)OC(C)(C)C)cc1)C(=O)OCc1ccccc1.CCO.[H][H].[Pd]>>CC(=O)NC(Cc1ccc(C(=O)OC(C)(C)C)cc1)C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CNCCNC1.C1CNCCNC1.CCO.CS(=O)(=O)c1ccc(CBr)cc1.Cl.Cl.[I-].[Na+]>>CS(=O)(=O)c1ccc(CN2CCCNCC2)cc1",
        "output": "248"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)OB(c2ccc(-c3cnc(N)cn3)c(F)c2)OC1(C)C.O=S(=O)(Nc1ccccc1Br)N1CCCC1>>Nc1cnc(-c2ccc(-c3ccccc3NS(=O)(=O)N3CCCC3)cc2F)cn1",
        "output": "933"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN.CO.Cl.ClCCl.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CNS(=O)(=O)c1ccccc1[N+](=O)[O-]",
        "output": "43"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(C)(C)c1nc2cc(N(C)C(C)=O)ccc2n1CC1CCOCC1>>CCOC(C)(C)c1nc2cc(NC)ccc2n1CC1CCOCC1",
        "output": "504"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)CCBr.CN(C)C=O.COc1ccc2c3c([nH]c2c1)CCCC3=O.O.O=C([O-])[O-].[Cs+].[Cs+]>>COc1ccc2c3c(n(CCC(C)(C)C)c2c1)CCCC3=O",
        "output": "470"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC=C(c2cc(C(=O)N3CCCCCC3)cs2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(c1csc(C2=CCNCC2)c1)N1CCCCCC1",
        "output": "800"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Cc1ccc(CCl)cc1[N+](=O)[O-].O>>Cc1ccc(CN2CCN(C(=O)OC(C)(C)C)CC2)cc1[N+](=O)[O-]",
        "output": "156"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.CCC(=O)N[C@H]1[C@H](O)C[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C.O.O=C(Cl)c1ccccc1.[Na+].[OH-]>>CCC(=O)N[C@H]1[C@H](O)C[C@H]2[C@@H]3CCc4cc(OC(=O)c5ccccc5)ccc4[C@H]3CC[C@@]21C",
        "output": "482"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(C(=O)O)cc2n1Cc1ccccc1.CCOC(C)=O.CN(C)c1ccncc1.ClCCCl.ClCCl.NN>>CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)c2ccc(C(=O)NN)cc2n1Cc1ccccc1",
        "output": "55"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1.O.O=[N+]([O-])O>>CCC(=C(CC)c1ccc(O)c([N+](=O)[O-])c1)c1ccc(O)cc1",
        "output": "21"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1cc(C(=O)O)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)cc1.F[P-](F)(F)(F)(F)F.N[C@H]1CC[C@H](O)CC1>>Cc1cc(C(=O)N[C@@H]2CC[C@@H](O)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CO.C[O-].Cc1nc(Cl)c(C#N)c2c1CCCC2.[Na+]>>COc1nc(C)c2c(c1C#N)CCCC2",
        "output": "433"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1ccc(C=C(C)c2ccc3c(c2)SCCC3(C)C)cc1.Cl.O.[K+].[OH-]>>CC(=Cc1ccc(C(=O)O)cc1)c1ccc2c(c1)SCCC2(C)C",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCC=CC[C@@](F)(C(=O)O)C(F)(F)F.CCOCC.[H][H]>>CCCCCCCC[C@@](F)(C(=O)O)C(F)(F)F",
        "output": "143"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COCCC(=O)O.Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)CN)cc1.F[P-](F)(F)(F)(F)F>>COCCC(=O)NCC(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1",
        "output": "133"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(C2(C(=O)N3CCN(C)CC3)CCOCC2)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1ccc(C2(CN3CCN(C)CC3)CCOCC2)cc1",
        "output": "112"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1[nH]c(CC)c(Cl)c1Cl.Cc1[nH]c(C(=O)O)cc1Cl>>CCc1[nH]c(C(=O)O)c(Cl)c1Cl",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1C[C@H]2CN(c3cncc(C(=O)O)c3)C[C@H]2C1.C[C@@H](N)c1ccccc1>>C[C@@H](NC(=O)c1cncc(N2C[C@@H]3CN(C(=O)OC(C)(C)C)C[C@@H]3C2)c1)c1ccccc1",
        "output": "790"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNCC1.Cc1cc(OCCCCl)ccc1-c1cn2c(n1)CC(C)CC2>>Cc1cc(OCCCN2CCCCC2)ccc1-c1cn2c(n1)CC(C)CC2",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCN(CC(=O)O)C(=O)OC(C)(C)C.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.NC12CC3CC(CC(C3)C1)C2>>CCCN(CC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)OC(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCC.CN(C)C=O.Fc1cccc(CBr)c1F.O.O=C([O-])[O-].O=Cc1cc(Cl)ccc1O.[K+].[K+]>>O=Cc1cc(Cl)ccc1OCc1cccc(F)c1F",
        "output": "127"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccc2ccccc2c1.CN(C)C=O.COC(=O)C(=O)c1ccc(O)cc1.[H-].[Na+]>>COC(=O)C(=O)c1ccc(OCc2ccc3ccccc3c2)cc1",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)N(C)C.CCOC(C)=O.COC(=O)c1ccc(Cl)nc1.Cc1cc(C(O)(C(C)c2ccc(O)cc2Cl)C(F)(F)F)cc(C)c1C#N.O.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)c1ccc(Oc2ccc(C(C)C(O)(c3cc(C)c(C#N)c(C)c3)C(F)(F)F)c(Cl)c2)nc1",
        "output": "516"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "FC(F)(F)c1nnc2ccc(N3CCNCC3)nn12.O=Cc1ccc2[nH]ccc2c1>>FC(F)(F)c1nnc2ccc(N3CCN(Cc4ccc5[nH]ccc5c4)CC3)nn12",
        "output": "567"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COc1cc(Cl)cc(Br)c1Cl.ClCCl.O>>Oc1cc(Cl)cc(Br)c1Cl",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CN(C)C(OC(C)(C)C)OC(C)(C)C.Cc1ccccc1.O=C(O)C1CN(C(=O)C(F)(F)F)C1>>CC(C)(C)OC(=O)C1CN(C(=O)C(F)(F)F)C1",
        "output": "768"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.N#Cc1cccc(C=O)c1.Nc1ccc(F)cc1>>N#Cc1cccc(C=Nc2ccc(F)cc2)c1",
        "output": "329"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cc1cc(/C=C/C(=O)OC(C)(C)C)sc1C=O.Cl>>Cc1cc(/C=C/C(=O)O)sc1C=O",
        "output": "158"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)c1c(-c2ccc(C)cn2)cnn1C.Cl.[Na+].[OH-]>>Cc1ccc(-c2cnn(C)c2C(=O)O)nc1",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.C[O-].N#Cc1ccc(Cl)nc1.O.[Na+]>>COc1ccc(C#N)cn1",
        "output": "433"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)NCCCC(=O)NCCCC(=O)c1ccc(Cl)cc1CCC(=O)O.CCN(CC)CC.CCOC(=O)CN.Cl.O=C(n1ccnc1)n1ccnc1>>CCOC(=O)CNC(=O)CCc1cc(Cl)ccc1C(=O)CCCNC(=O)CCCNC(C)=O",
        "output": "107"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)C=Cc1ccc(F)cc1C.CCOCC.CS(C)=O.Cc1cc(O)cc(OCc2ccccc2)c1.Cl.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C=Cc1ccc(Oc2cc(C)cc(OCc3ccccc3)c2)cc1C",
        "output": "564"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc(O)cc1C(=O)O.O.[Na+].[OH-]>>CC(C)(C)OC(=O)Nc1ccc(O)cc1C(=O)O",
        "output": "735"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.O=C([O-])O.O=C1CCC(=O)N1Br.[Na+].c1ccc(Oc2csc(C3OCCO3)c2)cc1>>Brc1sc(C2OCCO2)cc1Oc1ccccc1",
        "output": "807"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCl.Cn1cncc1C(O)(c1ccc2nc(C(F)(F)F)c(C(=O)N3CCCCC3)c(C(F)(F)F)c2c1)C1CCN(C(=O)OC(C)(C)C)CC1.Cn1cncc1C1(C(F)(F)F)Nc2ccc(C(=O)C3CCNCC3)cc2C(C(F)(F)F)=C1C(=O)N1CCCCC1.O=C(O)C(F)(F)F.[Na+].[OH-]>>Cn1cncc1C(O)(c1ccc2nc(C(F)(F)F)c(C(=O)N3CCCCC3)c(C(F)(F)F)c2c1)C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.CCN(CC)CC.CN(C)c1ccncc1.COCCCOc1cc(C[C@@H](C[C@H](N=[N+]=[N-])[C@@H](O)C[C@H](C(=O)NCC(C)(C)C(N)=O)C(C)C)C(C)C)ccc1OC.O>>COCCCOc1cc(C[C@@H](C[C@H](N=[N+]=[N-])[C@H](C[C@H](C(=O)NCC(C)(C)C(N)=O)C(C)C)OC(C)=O)C(C)C)ccc1OC",
        "output": "254"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(=O)c1cccc(N)n1.O>>CCOC(=O)c1cccc(NC(=O)OC(C)(C)C)n1",
        "output": "849"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.C[Si](C)(C)CCOCCl.Nc1[nH]ncc1Br.[H-].[Na+]>>C[Si](C)(C)CCOCn1ncc(Br)c1N",
        "output": "910"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCC1CO1.COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1O.CS(C)=O.O.O=C([O-])[O-].[K+].[K+]>>COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OCC1CO1",
        "output": "18"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)c1cn(C)c2cnc3cc(N4CCCC(C)(C)C4)c(F)cc3c2c1=O.Cl.O.[K+].[OH-]>>Cn1cc(C(=O)O)c(=O)c2c3cc(F)c(N4CCCC(C)(C)C4)cc3ncc21",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#CCOc1ccc(C[C@H](NC(=O)[C@@H](/C=C/CCCCCCC(=O)CCCCCCC)[C@@](O)(CC#N)C(=O)O)C(=O)OC)cc1.CO.[Li+].[OH-]>>CC#CCOc1ccc(C[C@H](NC(=O)[C@@H](/C=C/CCCCCCC(=O)CCCCCCC)[C@@](O)(CC#N)C(=O)O)C(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OCc1cncc(Br)c1.OB(O)c1ccc(F)cc1>>CC(=O)OCc1cncc(-c2ccc(F)cc2)c1",
        "output": "833"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(CC)CC.C[Si](C)(C)C#N.ClCCl.[O-][n+]1ccc(Cc2ccccc2)cc1>>N#Cc1cc(Cc2ccccc2)ccn1",
        "output": "720"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.COc1ccc2c(=O)[nH]ccc2c1.O=C1CCC(=O)N1Br>>COc1ccc2c(=O)[nH]cc(Br)c2c1",
        "output": "518"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.COc1cc(OC)c2c(=O)cc(-c3ccccc3Cl)oc2c1[C@@H]1CCN(C)[C@H]1CO.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.O=C([O-])O.[Na+]>>COc1cc(OC)c2c(=O)cc(-c3ccccc3Cl)oc2c1[C@@H]1CCN(C)[C@H]1C=O",
        "output": "610"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.NC(Cc1ccc(F)cc1)C(O)c1ccc(C(F)(F)F)cc1.O.O=C(Cl)C1CCCCC1.O=C([O-])O.[Na+]>>O=C(NC(Cc1ccc(F)cc1)C(O)c1ccc(C(F)(F)F)cc1)C1CCCCC1",
        "output": "45"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CI.CN(C)C=O.COc1ccc2[nH]cc(-c3cc4c(OC)ncnc4n3S(=O)(=O)c3ccc(C)cc3)c2c1.[H-].[Na+]>>COc1ccc2c(c1)c(-c1cc3c(OC)ncnc3n1S(=O)(=O)c1ccc(C)cc1)cn2C",
        "output": "191"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCCCCCCCCCCC(=O)Cl.CNCCCN(C)C.ClCCl>>CCCCCCCCCCCCCCCC(=O)N(C)CCCN(C)C",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.CN(C)CCCl.O=C([O-])[O-].O=[N+]([O-])c1cccc(O)c1.[K+].[K+]>>CN(C)CCOc1cccc([N+](=O)[O-])c1",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(=O)O.CC(C)COC(=O)Cl.CN1CCOCC1.CN1C[C@H](CNN)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21>>CC(=O)NNC[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1",
        "output": "459"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.Cc1oc(-c2ccccc2)nc1COc1ccc(COc2cncc(CC#N)c2)cc1.Cl.O.[Na+].[OH-]>>Cc1oc(-c2ccccc2)nc1COc1ccc(COc2cncc(CC(=O)O)c2)cc1",
        "output": "259"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@H](NC(=O)OCc1ccccc1)C(=O)O.Cc1cccc(C)c1NC(=O)c1cccn1N>>Cc1cccc(C)c1NC(=O)c1cccn1NC(=O)[C@H](C)NC(=O)OCc1ccccc1",
        "output": "459"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCO.CCCCOC(=O)CCc1ccc(N)cc1.ClCCN(CCCl)c1ccc(Cl)cc1.O=C([O-])[O-].[K+].[K+]>>CCCCOC(=O)CCc1ccc(N2CCN(c3ccc(Cl)cc3)CC2)cc1",
        "output": "640"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CCO.O=[N+]([O-])c1c(Cl)ccc(Cl)c1O.[Pt]>>Nc1c(Cl)ccc(Cl)c1O",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)c1cn(-c2ccnc(Cl)c2)nc1-c1ccccc1Cl.[Na+].[OH-]>>O=C(O)c1cn(-c2ccnc(Cl)c2)nc1-c1ccccc1Cl",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.C[Si](C)(C)C#Cc1ccc(OC(F)F)cc1.ClCCl.ClCCl.O=C([O-])[O-].[Cs+].[Cs+]>>C#Cc1ccc(OC(F)F)cc1",
        "output": "337"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCO.Cc1oc(-c2ccccc2)nc1CCOc1ccc(C=O)cc1.[BH4-].[Na+]>>Cc1oc(-c2ccccc2)nc1CCOc1ccc(CO)cc1",
        "output": "356"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)CC(O)CCCCN1CCCc2nc(-c3ccc(C)cc3)c(-c3ccc(C)cc3)nc21.O.[Na+].[OH-]>>Cc1ccc(-c2nc3c(nc2-c2ccc(C)cc2)N(CCCCC(O)CC(=O)O)CCC3)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1cccc(-c2ccnc(NCCc3ccc(O)cc3)n2)c1.O=S(=O)(Cl)Cc1ccccc1>>O=S(=O)(Cc1ccccc1)Nc1cccc(-c2ccnc(NCCc3ccc(O)cc3)n2)c1",
        "output": "194"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCc1nc2c(N)nc3ccccc3c2n1CCN.CS(=O)(=O)Cl.c1ccncc1>>CCCCc1nc2c(N)nc3ccccc3c2n1CCNS(C)(=O)=O",
        "output": "493"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.CS(=O)(=O)NC(=O)C1CCN(C(=O)OCc2ccccc2)CC1.[Pd]>>CS(=O)(=O)NC(=O)C1CCNCC1",
        "output": "428"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.N#Cc1cnc2cnc(F)cc2c1Cl.Nc1ccc(F)c(Cl)c1.O.O=C([O-])O.[Cl-].[Na+].[Na+]>>N#Cc1cnc2cnc(F)cc2c1Nc1ccc(F)c(Cl)c1",
        "output": "115"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cc1ccc(C(=O)O)cc1-c1ccc2c(O)nncc2c1.O=S(Cl)Cl>>COC(=O)c1ccc(C)c(-c2ccc3c(O)nncc3c2)c1",
        "output": "33"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)OB(c2ccc([N+](=O)[O-])c(NCc3ccccc3)c2)OC1(C)C.COCCOC.NS(=O)(=O)c1cccc(Br)c1.O.O=C([O-])[O-].[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NS(=O)(=O)c1cccc(-c2ccc([N+](=O)[O-])c(NCc3ccccc3)c2)c1",
        "output": "933"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCCBr.CC(C)=O.O=C([O-])[O-].Oc1ccc(O)cc1.[K+].[K+]>>Oc1ccc(OCCBr)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Clc1ncc(Cl)c(Cl)n1.Nc1ccc2[nH]ncc2c1.O=C([O-])[O-].[Na+].[Na+]>>Clc1ncc(Cl)c(Nc2ccc3[nH]ncc3c2)n1",
        "output": "161"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.O=Cc1cccc(OCc2ccc3ccc(Cl)cc3n2)c1.[BH4-].[Na+]>>OCc1cccc(OCc2ccc3ccc(Cl)cc3n2)c1",
        "output": "356"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)c1ccc(CN2CCN(C)CC2)c(C(F)(F)F)c1.Cl.[Na+].[OH-]>>CN1CCN(Cc2ccc(C(=O)O)cc2C(F)(F)F)CC1",
        "output": "5"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.ClCCl.N#CCC(=O)O.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1F)nn2CC1CCN1>>N#CCC(=O)N1CCC1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.O=C1NCCC1Cc1ccc(Cl)cc1>>Clc1ccc(CC2CCNC2)cc1",
        "output": "112"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)CC(c2cccc3ccccc23)c2ccc(OCC3CO3)cc2O1.CCO.CN>>CNCC(O)COc1ccc2c(c1)OC(C)(C)CC2c1cccc2ccccc12",
        "output": "16"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.COCCN(CCc1ccc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccc(F)cc5)cc4F)c3s2)nc1)C(=O)OC(C)(C)C.Cl>>COCCNCCc1ccc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccc(F)cc5)cc4F)c3s2)nc1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COc1cccc(C=CCCC(=O)O)c1.[Pd]>>COc1cccc(CCCCC(=O)O)c1",
        "output": "362"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.Clc1ncc(Cl)c(Cl)n1.c1nc2c([nH]1)CCNCC2>>Clc1ncc(Cl)c(N2CCc3nc[nH]c3CC2)n1",
        "output": "162"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.OCc1c(F)cc(Br)cc1F.[Mn+4].[O-2].[O-2]>>O=Cc1c(F)cc(Br)cc1F",
        "output": "179"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCOC(=O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)C2CCCC2)C1.O.[Li+].[OH-]>>O=C(O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)C2CCCC2)C1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2cc(F)c(=O)[nH]c2=O)C[C@@H]1O.CN(C)c1ccncc1.ClCCl.O=C1CCC(=O)O1.c1ccncc1>>CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2cc(F)c(=O)[nH]c2=O)C[C@@H]1OC(=O)CCC(=O)O",
        "output": "139"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)O)cn2)c1O.NC1CC1>>Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)NC3CC3)cn2)c1O",
        "output": "674"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(CC(=O)O)NC(=O)OCc1ccccc1.CN(C)C=O.O.O=C(n1ccnc1)n1ccnc1.OCCN1CCCCC1>>CC(C)(CC(=O)OCCN1CCCCC1)NC(=O)OCc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(C)=O.CCN(CC)CC.CN[C@H]1CN(Cc2ccccc2)CC[C@H]1C.CS(=O)(=O)Cl.Clc1ncnc2[nH]ccc12.O=C([O-])O.[Na+]>>C[C@@H]1CCN(Cc2ccccc2)C[C@@H]1N(C)c1ncnc2[nH]ccc12",
        "output": "540"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C(N)C(=O)c1nnc(C(C)(C)C)o1.CCN(CC)CC.CN(C)C=O.CS(=O)(=O)On1nnc2ccccc21.Cl.Nc1cnc(-c2ccccc2)n(CC(=O)O)c1=O.O>>CC(C)C(NC(=O)Cn1c(-c2ccccc2)ncc(N)c1=O)C(=O)c1nnc(C(C)(C)C)o1",
        "output": "645"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1cccc(Br)c1.CC#N.CN(C)C=O.Nc1nc(N)c2nc(CN3CCNCC3)nnc2n1.O.O=C(O)C(F)(F)F.O=C([O-])[O-].[K+].[K+]>>Nc1nc(N)c2nc(CN3CCN(Cc4cccc(Br)c4)CC3)nnc2n1",
        "output": "248"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "B.C1CCOC1.C1CCOC1.CCO.Nc1cc(F)ccc1C(=O)O>>Nc1cc(F)ccc1CO",
        "output": "72"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COc1cc(OC)c2c(=O)[nH]c(-c3cc(C)c(NC(=O)COC(C)=O)c(C)c3)nc2c1.Cl.ClCCl.O.O=C([O-])[O-].[K+].[K+]>>COc1cc(OC)c2c(=O)[nH]c(-c3cc(C)c(NC(=O)CO)c(C)c3)nc2c1",
        "output": "687"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@@H]1c1nnn(-c2cccc(C#N)c2)n1.ClCCl.O=C(O)C(F)(F)F>>N#Cc1cccc(-n2nnc([C@H]3CCCN3)n2)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CO.COC(=O)c1ccc2c(c1)CCCN(c1cc(Cl)c3cc(Cl)ccc3n1)C2.Cl.O.[Na+].[OH-]>>O=C(O)c1ccc2c(c1)CCCN(c1cc(Cl)c3cc(Cl)ccc3n1)C2",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1=COCCC1.C=CC(C)CO.CCOCC.Cc1ccc(S(=O)(=O)O)cc1>>C=CC(C)COC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC1(C)Cc2c(Cl)ccc([N+](=O)[O-])c2O1.O.[Fe]>>CC1(C)Cc2c(Cl)ccc(N)c2O1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C(O)CCOCCN1CCC(Oc2ccc(OC(F)(F)F)cc2)CC1.O=S(Cl)Cl>>O=C(Cl)CCOCCN1CCC(Oc2ccc(OC(F)(F)F)cc2)CC1",
        "output": "53"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1CN(C(=O)CCc2c(C=O)[nH]c3c2CCCC3)CC(C)N1.CNS(=O)(=O)c1ccc2c(c1)CC(=O)N2>>CNS(=O)(=O)c1ccc2c(c1)/C(=C/c1[nH]c3c(c1CCC(=O)N1CC(C)NC(C)C1)CCCC3)C(=O)N2",
        "output": "911"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCn1c(=O)nc(-c2cccc(Cl)c2)c2ccc(C(C)O)nc21.ClC(Cl)Cl.[Mn+4].[O-2].[O-2]>>CCn1c(=O)nc(-c2cccc(Cl)c2)c2ccc(C(C)=O)nc21",
        "output": "456"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cc(Oc2ccccc2)ccc1NC(=O)c1ccc(OCc2ccc(OC)c(OC)c2)c(Cl)c1.CO.O>>COc1ccc(COc2ccc(C(=O)Nc3ccc(Oc4ccccc4)cc3C(=O)O)cc2Cl)cc1OC",
        "output": "5"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C1CCOC1.CC(C)[N-]C(C)C.CN(C)C=O.Cc1cc(Br)cs1.[Li+]>>Cc1cc(Br)c(C=O)s1",
        "output": "617"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "NCCc1ccc(CN2CCCC2)cc1.O=C(O)c1ccc(-c2ccc(Cl)cc2)cn1>>O=C(NCCc1ccc(CN2CCCC2)cc1)c1ccc(-c2ccc(Cl)cc2)cn1",
        "output": "137"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.N#Cc1ccc(-c2nc(-c3ccccc3)cs2)cc1.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>c1ccc(-c2csc(-c3ccc(-c4nnn[nH]4)cc3)n2)cc1",
        "output": "390"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(F)c(Cl)c1Cl.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>Nc1ccc(F)c(Cl)c1Cl",
        "output": "782"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC(CO)c1ccc2c(c1)N(C(=O)OC(C)(C)C)CCC2(C)C.CCOCC.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CCCCCC(C=O)c1ccc2c(c1)N(C(=O)OC(C)(C)C)CCC2(C)C",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc(CO)ccc1Cl.O=[Mn]=O.c1ccccc1>>COc1cc(C=O)ccc1Cl",
        "output": "179"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)c1cc(C#N)c(Cl)nc1C.N>>CC(=O)c1cc(C#N)c(N)nc1C",
        "output": "388"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccnc(-c4ccc5c(=O)n(C)n(C)c5c4)c3)sc2c1-c1ccc(Cl)cc1.CO.[Na+].[OH-]>>Cc1cc2nc(-c3ccnc(-c4ccc5c(=O)n(C)n(C)c5c4)c3)sc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.CC(C)(F)CO[C@H]1CN(C(=O)OC(C)(C)C)[C@@H]([C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)CO1.CCN(CC)CC.ClCCl>>CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1CO[C@@H](OCC(C)(C)F)CN1C(=O)OC(C)(C)C",
        "output": "339"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)Cc1ccc(N2CCN(C)CC2)cc1.N>>CN1CCN(c2ccc(CC(N)=O)cc2)CC1",
        "output": "432"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CI.O=C(/C=C/c1ccc(Cl)cc1F)c1ccc(=O)[nH]c1.O=C([O-])[O-].[K+].[K+]>>Cn1cc(C(=O)/C=C/c2ccc(Cl)cc2F)ccc1=O",
        "output": "191"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(C)(C)OC(=O)NCCBr.COC(=O)c1c(O)cnc(OC(C)C)c1C.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1c(OCCNC(=O)OC(C)(C)C)cnc(OC(C)C)c1C",
        "output": "608"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCOC(C)=O.COc1ccc(C(C)C(O)(c2ccc(OC)nc2)C(F)(F)F)c(Cl)c1.Cl.O>>COc1ccc(C(C)C(O)(c2ccc(=O)[nH]c2)C(F)(F)F)c(Cl)c1",
        "output": "758"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COC(=O)CNC(=O)/C=C/c1ccccc1F.O.[Na+].[OH-]>>O=C(O)CNC(=O)/C=C/c1ccccc1F",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCc1nnc(-c2ccc(CO[Si](C)(C)C(C)(C)C)cc2)o1.CO.Cl>>CCc1nnc(-c2ccc(CO)cc2)o1",
        "output": "708"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)C(Oc1ccccc1)c1ccc(Oc2ccccc2)cc1.[K+].[OH-]>>O=C(O)C(Oc1ccccc1)c1ccc(Oc2ccccc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)[C@@H](CO)NC(=O)OC(C)(C)C.ClCCl.O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1>>CC(C)[C@@H](C=O)NC(=O)OC(C)(C)C",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.CCCC(=O)c1ccc(O)cc1.O=C([O-])[O-].OCCOCCCl.[K+].[K+]>>CCCC(=O)c1ccc(OCCOCCO)cc1",
        "output": "74"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(F)(F)c1nn2cc(-c3nc4c([N+](=O)[O-])cccc4o3)nc2s1.[Pd]>>CC(F)(F)c1nn2cc(-c3nc4c(N)cccc4o3)nc2s1",
        "output": "269"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CCO[C@@H]1CN(C2CCOCC2)C[C@H]1N.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CO.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)CNC(=O)c1cccc(C(F)(F)F)c1.On1nnc2ccccc21.[NH4+].[OH-]>>CCO[C@@H]1CN(C2CCOCC2)C[C@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.O.O=C([O-])[O-].O=Cc1ccc(Br)s1.OB(O)c1ccccc1.[K+].[K+].[Pd]>>O=Cc1ccc(-c2ccccc2)s1",
        "output": "864"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCCCCCCCCCCCCCOc1cc(CO)cc(OCCCCCCCCCCCCCCCCCC)c1OCCCCCCCCCCCCCCCCCC.CN(C)C=O.ClCCl.O=S(Cl)Cl>>CCCCCCCCCCCCCCCCCCOc1cc(CCl)cc(OCCCCCCCCCCCCCCCCCC)c1OCCCCCCCCCCCCCCCCCC",
        "output": "81"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(F)(F)CO.CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCC(C)(F)F)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCCO.COc1cc(N)c(C)cc1Cl.Cl.N#Cc1cnc2cc3c(cc2c1Cl)ncn3CCN1CCOCC1.O.O=C([O-])[O-].[Na+].[Na+].c1ccncc1>>COc1cc(Nc2c(C#N)cnc3cc4c(cc23)ncn4CCN2CCOCC2)c(C)cc1Cl",
        "output": "115"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.COc1ccc2c(c1)c(-c1cc3nc(CNC(=O)CCCO[Si](C)(C)C(C)(C)C)cnc3n1COCC[Si](C)(C)C)cn2C>>COc1ccc2c(c1)c(-c1cc3nc(CNC(=S)CCCO[Si](C)(C)C(C)(C)C)cnc3n1COCC[Si](C)(C)C)cn2C",
        "output": "695"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCO.Cc1ccc(C(=O)O)c([N+](=O)[O-])c1I.Cl.[Fe]>>Cc1ccc(C(=O)O)c(N)c1I",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.CSc1nccc(-c2noc3c(F)c4c(cc23)CC2(C(=O)NC(=O)NC2=O)[C@H]2[C@H](C)O[C@H](C)CN42)n1.ClCCl.O.O=S([O-])OO.[K+]>>C[C@@H]1CN2c3c(cc4c(-c5ccnc(S(C)(=O)=O)n5)noc4c3F)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1",
        "output": "840"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.N[C@@H]1c2ccccc2C[C@@H]1O>>CC(C)(C)OC(=O)N[C@@H]1c2ccccc2C[C@@H]1O",
        "output": "686"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNCC1.CCN(C(=O)CCl)c1cc(OC)ccc1C1CCc2cc(OC)ccc2C1.CN(C)C=O.O=C([O-])O.O=C([O-])[O-].[K+].[K+].[Na+]>>CCN(C(=O)CN1CCCCC1)c1cc(OC)ccc1C1CCc2cc(OC)ccc2C1",
        "output": "340"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.COc1cccc(C=O)c1O.ClCCl.O=C([O-])[O-].[K+].[K+]>>COc1cccc(C=O)c1OC(C)=O",
        "output": "46"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CS(C)=O.O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)CS(=O)c1ccccc1>>O=C(CS(=O)c1ccccc1)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CCCc1ccccc1",
        "output": "650"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)OB(c2ccc(N)nc2)OC1(C)C.Cc1cc(-c2cc(C(F)(F)F)nc(-c3ccnc(Cl)c3)n2)ccc1C(F)(F)F>>Cc1cc(-c2cc(C(F)(F)F)nc(-c3ccnc(-c4ccc(N)nc4)c3)n2)ccc1C(F)(F)F",
        "output": "968"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1c(Br)cccc1-n1c(=O)c2cc(F)ccc2n(C)c1=O.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1c(B2OC(C)(C)C(C)(C)O2)cccc1-n1c(=O)c2cc(F)ccc2n(C)c1=O",
        "output": "942"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrC(Br)(Br)Br.ClCCl.O=C([O-])O.OCCCSc1ccc(OCc2ccccc2)cc1.[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>BrCCCSc1ccc(OCc2ccccc2)cc1",
        "output": "378"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc([N+](=O)[O-])ccc1Nc1ccc2c(c1)CC(NCc1ccc(Cl)c(Cl)c1)C2.O.[Na+].[OH-]>>O=C(O)c1cc([N+](=O)[O-])ccc1Nc1ccc2c(c1)CC(NCc1ccc(Cl)c(Cl)c1)C2",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCCCCCCCCCC(=O)O.CO.O=S(=O)(O)c1cccs1>>CCCCCCCCCCCCCCCC(=O)OC",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)C=O.Cl.Clc1cnc(Cl)c(Cl)c1.O=C1N(c2ccccc2Cl)CC[C@]12CCCNC2>>O=C1N(c2ccccc2Cl)CC[C@]12CCCN(c1ncc(Cl)cc1Cl)C2",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCCCCCC(=O)Cl.CCOCC.NCCCCCC(=O)O.O.[Na+].[OH-]>>CCCCCCCCCCCC(=O)NCCCCCC(=O)O",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)OC[C@@H]1c2ccccc2C[C@H]1N.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.ClCCl.O=C(O)c1cc2sc(Cl)c(Cl)c2[nH]1.On1nnc2ccccc21>>CC(C)(C)[Si](C)(C)OC[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1",
        "output": "137"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CO.C[O-].OC(CCl)(c1ccc(F)cc1)c1ccc(-c2ccccc2)cc1.[Na+].c1c[nH]cn1>>OC(Cn1ccnc1)(c1ccc(F)cc1)c1ccc(-c2ccccc2)cc1",
        "output": "611"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.COC(=O)c1ccccc1C.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COC(=O)c1ccccc1CBr",
        "output": "545"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(C)=O.COc1cc(N2CCN(C(C)=O)CC2)c(C)cc1[N+](=O)[O-].O=[Pt]=O>>COc1cc(N2CCN(C(C)=O)CC2)c(C)cc1N",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=Cc1ccncc1[N+](=O)[O-].OCCO>>O=[N+]([O-])c1cnccc1C1OCCO1",
        "output": "117"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)Cc1cccc(OCc2ccc(OC)c(OCc3nc(-c4ccccc4)oc3C)c2)c1.Cl.O.[Na+].[OH-]>>COc1ccc(COc2cccc(CC(=O)O)c2)cc1OCc1nc(-c2ccccc2)oc1C",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.CCOc1nc2cccc(C)c2c(=O)o1.O=C1CCC(=O)N1Br>>CCOc1nc2cccc(CBr)c2c(=O)o1",
        "output": "29"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCOC(C)=O.ClCCl.NCCc1ccccc1.O=S(=O)(Cl)c1cccc(CC2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1>>O=S(=O)(NCCc1ccccc1)c1cccc(CC2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1",
        "output": "43"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N(CCc1ccc(O)cc1)C[C@H](O)c1cccnc1.Cc1cccc(C)n1.ClCCl.N.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N(CCc1ccc(OS(=O)(=O)C(F)(F)F)cc1)C[C@H](O)c1cccnc1",
        "output": "731"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CCO.CCOC(=O)c1cn([C@@H](C)CO)c2c(F)c(N3CCN(C)CC3)c(F)cc2c1=O.[K+].[OH-]>>C[C@@H](CO)n1cc(C(=O)O)c(=O)c2cc(F)c(N3CCN(C)CC3)c(F)c21",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CN(C)CCCCl.Cc1ccc2c(I)n[nH]c2c1.Cl.O.O=C([O-])[O-].[K+].[K+]>>Cc1ccc2c(I)nn(CCCN(C)C)c2c1",
        "output": "604"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)CBr.COc1ccc(-c2ccc3c(c2)COC3=O)c(O)c1OC(F)F.O=C([O-])[O-].[K+].[K+]>>COc1ccc(-c2ccc3c(c2)COC3=O)c(OCC(C)C)c1OC(F)F",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C(C)(C#N)N1C(=O)c2ccc3c(ccn3C)c2C1=O.CCOC(C)=O.CCOCC.ClCCl.O=S(=O)(O)O.[Na+].[OH-]>>CC(C)C(C)(C(N)=O)N1C(=O)c2ccc3c(ccn3C)c2C1=O",
        "output": "8"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COc1cccc(O)c1.N#Cc1cccnc1Cl.O=C([O-])[O-].[K+].[K+]>>COc1cccc(Oc2ncccc2C#N)c1",
        "output": "516"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCC1(CC(=O)OCC)OCCc2c1[nH]c1c(C)c(O)cc(C#N)c21.CCO.[Na+].[OH-]>>CCCC1(CC(=O)O)OCCc2c1[nH]c1c(C)c(O)cc(C#N)c21",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#CCCO.C1CCOC1.CC(C)NC(C)C.CCOCC.Cl.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O.Oc1ccc(-c2ccc(Br)cc2)cc1.[Cu]I>>OCCC#Cc1ccc(-c2ccc(O)cc2)cc1",
        "output": "659"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Cn1c2c(c3ccccc31)CCN(C(=O)OCc1ccccc1)C2.CO.[Pd]>>CC(C)(C)OC(=O)Cn1c2c(c3ccccc31)CCNC2",
        "output": "428"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCNc1nc(-c2cc(C)cc(OC)c2)c(-c2ccnc(Cl)n2)s1.Nc1ccc(N2CCOCC2)c(C(F)(F)F)c1.OCC(F)(F)F>>CCNc1nc(-c2cc(C)cc(OC)c2)c(-c2ccnc(Nc3ccc(N4CCOCC4)c(C(F)(F)F)c3)n2)s1",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#Cc1c(-c2ccccc2)noc1C.Nc1ccccc1I>>Cc1onc(-c2ccccc2)c1C#Cc1ccccc1N",
        "output": "664"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "NCC(c1ccncc1)c1ccc(C(F)(F)F)nc1.O=C(O)c1cccc(Cl)c1Cl>>O=C(NCC(c1ccncc1)c1ccc(C(F)(F)F)nc1)c1cccc(Cl)c1Cl",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)N=C=NC(C)C.CN(C)C=O.CSSC(C)(C)CCC(=O)O.NCCCOc1cc(CO)cc(CO)c1.O.O.On1nnc2ccccc21>>CSSC(C)(C)CCC(=O)NCCCOc1cc(CO)cc(CO)c1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CO.Cc1cc([C@@H]2CC[C@@H](c3nnc4n3-c3ccc(Cl)cc3CNC4)CC2)no1.F[P-](F)(F)(F)(F)F.O.O=C(O)CO>>Cc1cc([C@@H]2CC[C@@H](c3nnc4n3-c3ccc(Cl)cc3CN(C(=O)CO)C4)CC2)no1",
        "output": "633"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)c1ccncc1.Cl.ClCCl.OCc1cccc(Br)c1>>CC(C)(C)[Si](C)(C)OCc1cccc(Br)c1",
        "output": "193"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Brc1ccc2ccc3c(Br)ccc4ccc1c2c43.CC(=O)O.CC(=O)O.CC(C)(C)[O-].Cc1ccccc1.[Na+].[Pd].c1ccc(Nc2ccc3ccccc3c2)cc1>>Brc1ccc2ccc3c(N(c4ccccc4)c4ccc5ccccc5c4)ccc4ccc1c2c43",
        "output": "894"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.CCCCCC(=O)CCN1CCN(CCCc2ccccc2)CC1.CCO.[BH4-].[Na+]>>CCCCCC(O)CCN1CCN(CCCc2ccccc2)CC1",
        "output": "91"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "[N-]=[N+]=NCc1cc(F)cnc1Cl.[Pt]>>NCc1cc(F)cnc1Cl",
        "output": "89"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)O.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.Cl.O.OC1CCCC1>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)OC1CCCC1",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.COC(=O)C1CCc2ccc[n+]([O-])c21.ClC(Cl)Cl.O.O=P(Cl)(Cl)Cl>>COC(=O)C1CCc2ccc(Cl)nc21",
        "output": "2"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.CN(C)C=O.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C.F[P-](F)(F)(F)(F)F.N[C@H]1CCN(Cc2ccccc2)C1.O.O=C([O-])O.[Na+]>>COc1cc(C(=O)N[C@H]2CCN(Cc3ccccc3)C2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CN(C)CCc1ccc([N+](=O)[O-])c2[nH]ncc12.[Ni]>>CN(C)CCc1ccc(N)c2[nH]ncc12",
        "output": "269"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.O=[N+]([O-])c1ccc(F)cc1F.OC1CCC(O)CC1.[H-].[Na+]>>O=[N+]([O-])c1ccc(F)cc1OC1CCC(O)CC1",
        "output": "485"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)N1CCNCC1.CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](CNC(=O)c2cc(-c3ccc(F)nc3)nc3ccccc23)CC1.CS(C)=O.c1ccncc1>>CC(=O)N1CCN(c2ccc(-c3cc(C(=O)NC[C@@H]4CC[C@@H](CNC(=O)OC(C)(C)C)CC4)c4ccccc4n3)cn2)CC1",
        "output": "756"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCN(C1(C(=O)O)CC2CCC(C1)O2)S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl>>CCOC(=O)CCN(C1(C(=O)Cl)CC2CCC(C1)O2)S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1",
        "output": "56"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(-n2nc(Cl)cc2-c2ccc(OCc3ccccc3)cc2)cc1.CSc1ccccc1>>COc1ccc(-n2nc(Cl)cc2-c2ccc(O)cc2)cc1",
        "output": "23"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OCCNC(=O)[C@@H](N)Cc1ccc(OC(F)(F)F)cc1.O=C(O)c1ccc(Oc2ccc(C(F)(F)F)cc2)cc1>>CC(=O)OCCNC(=O)[C@H](Cc1ccc(OC(F)(F)F)cc1)NC(=O)c1ccc(Oc2ccc(C(F)(F)F)cc2)cc1",
        "output": "718"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(C)=O.O.O=C(OCc1ccccc1)C1(NS(=O)(=O)c2ccc(Oc3ccc(F)cc3)cc2)CCCC1.[Na+].[OH-]>>O=C(O)C1(NS(=O)(=O)c2ccc(Oc3ccc(F)cc3)cc2)CCCC1",
        "output": "186"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.COC(=O)Cl.ClCCl.N[C@H]1CCCC[C@@H]1n1cnc(C(=O)N2CCN(Cc3ccccc3)C[C@H]2Cc2ccccc2)c1-c1ccccc1>>COC(=O)N[C@H]1CCCC[C@@H]1n1cnc(C(=O)N2CCN(Cc3ccccc3)C[C@H]2Cc2ccccc2)c1-c1ccccc1",
        "output": "94"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(-c2ccc(OC)c(F)c2)c2ncnn12.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(-c2ccc(OC)c(F)c2)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.C[S-].O=C(O)CCCCCCCBr.[Na+]>>CSCCCCCCCC(=O)O",
        "output": "185"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNCC1.CCO.Cc1c(C(=O)NCCCN2CCCC2=O)c[nH]c1C=O.O=C1Cc2c(cccc2C2CCNCC2)N1>>Cc1c(C(=O)NCCCN2CCCC2=O)c[nH]c1C=C1C(=O)Nc2cccc(C3CCNCC3)c21",
        "output": "440"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CNC.Cl.O=C(Cl)CCCCl.[Na+].[OH-]>>CN(C)C(=O)CCCCl",
        "output": "125"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COc1ccccc1COCCCOc1ccc(N2C(=O)CN(C(=O)OC(C)(C)C)C[C@@H]2CO)cc1.Clc1ccc2ccccc2n1.[H-].[Na+]>>COc1ccccc1COCCCOc1ccc(N2C(=O)CN(C(=O)OC(C)(C)C)C[C@@H]2COc2ccc3ccccc3n2)cc1",
        "output": "433"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.CCCCCCCCc1ccc(OCC(O)Cn2ccc(C(=O)OC(C)(C)C)c2)cc1.CS(C)=O.O=C([O-])O.[Cl-].[Na+].[Na+]>>CCCCCCCCc1ccc(OCC(=O)Cn2ccc(C(=O)OC(C)(C)C)c2)cc1",
        "output": "87"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccc2[nH]c3ccc(Br)cc3c2c1.C1CCOC1.CCCCCCBr.[H-].[Na+]>>CCCCCCn1c2ccc(Br)cc2c2cc(Br)ccc21",
        "output": "470"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC(=O)[O-].Cc1ccccc1.NC[C@@H]1CCN(C(=O)C2CC2)C1.O=C([O-])[O-].O=[N+]([O-])c1ccc(C(F)(F)F)cc1Cl.[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>O=C(C1CC1)N1CC[C@@H](CNc2cc(C(F)(F)F)ccc2[N+](=O)[O-])C1",
        "output": "304"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CN(C)C(=O)CCl.Cl.Cn1ccc2c(-c3ccc(OCCC4CCNCC4)c(C(F)(F)F)c3)nc(C#N)nc21.O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CN(C)C(=O)CN1CCC(CCOc2ccc(-c3nc(C#N)nc4c3ccn4C)cc2C(F)(F)F)CC1",
        "output": "340"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)Cc1ccc(CCc2cc(F)cc(F)c2N)cc1.CCCCCCCN=C=O.c1ccccc1>>CCCCCCCNC(=O)Nc1c(F)cc(F)cc1CCc1ccc(CC(C)(C)C)cc1",
        "output": "176"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.CNOC.COC[C@H](C)Oc1cc(OCc2ccccc2)cc(C(=O)O)c1.Cl>>COC[C@H](C)Oc1cc(OCc2ccccc2)cc(C(=O)N(C)OC)c1",
        "output": "828"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1sc2nc(-c3ccccn3)nc(Cl)c2c1Cl.NCCc1ccc2c(c1)OCCO2>>Cc1sc2nc(-c3ccccn3)nc(NCCc3ccc4c(c3)OCCO4)c2c1Cl",
        "output": "723"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O.CCN=C=NCCCN(C)C.COC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](N)C(C)C.ClCCl.On1nnc2ccccc21>>COC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(C)C",
        "output": "133"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NC1CCNCC1.CN(C)C=O.FC(F)(F)c1cnc(Cl)c(Cl)c1.NC(=O)[O-].[K+]>>CC(C)(C)OC(=O)NC1CCN(c2ncc(C(F)(F)F)cc2Cl)CC1",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cl.Cl.N[C@@H]1CN2CCC1CC2.O=C(O)/C=C/c1ccccc1[N+](=O)[O-]>>O=C(/C=C/c1ccccc1[N+](=O)[O-])N[C@@H]1CN2CCC1CC2",
        "output": "767"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCN(Cc2ccc(Cl)cc2N2Cc3cccnc3C2)CC1.ClCCl.O=C(O)C(F)(F)F>>Clc1ccc(CN2CCNCC2)c(N2Cc3cccnc3C2)c1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CN(C)CCN1CCN(C(=O)Nc2cc(Oc3ccc([N+](=O)[O-])cc3F)ncn2)CC1.CO.[C].[H][H].[Pd]>>CN(C)CCN1CCN(C(=O)Nc2cc(Oc3ccc(N)cc3F)ncn2)CC1",
        "output": "335"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)c1ccc(-c2c(C)c(Cl)cc(C(C)=O)c2OC)cc1F.N>>COc1c(C(C)=O)cc(Cl)c(C)c1-c1ccc(C(N)=O)c(F)c1",
        "output": "67"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)NCc1cccc2c1CCNC2.CO.O.O=C([O-])O.O=CC1CC1.[BH3-]C#N.[Na+].[Na+]>>CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)NCc1cccc2c1CCN(CC1CC1)C2",
        "output": "858"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CS(=O)(=O)Cc1ccc(N)cn1.O=C(Cl)Oc1ccccc1.c1ccncc1>>CS(=O)(=O)Cc1ccc(NC(=O)Oc2ccccc2)cn1",
        "output": "763"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Nc1ccc(F)cc1.O=c1[nH]c2nccc(Cl)c2c2ccccc12>>O=c1[nH]c2nccc(Nc3ccc(F)cc3)c2c2ccccc12",
        "output": "922"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCOC(=O)c1c(Cl)c2cc(C(=O)c3ccc(OC(F)(F)F)cc3)ccc2n1-c1ccc(OC2CCCC2)cc1.Cl.O.[Na+].[OH-]>>O=C(c1ccc(OC(F)(F)F)cc1)c1ccc2c(c1)c(Cl)c(C(=O)O)n2-c1ccc(OC2CCCC2)cc1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Fc1cnc(Cl)nc1Cl.O.[Na]>>COc1nc(Cl)ncc1F",
        "output": "461"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Clc1cc(NC2CCCC2)c2[nH]c(C3=N[C@H](CCN4CCNCC4)CS3)cc2c1.O=C(O)CO>>O=C(CO)N1CCN(CC[C@@H]2CSC(c3cc4cc(Cl)cc(NC5CCCC5)c4[nH]3)=N2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COc1ccc(C(=O)Cl)cc1OC.ClCCl.N#CC1(c2ccc(N)cc2)CC1>>COc1ccc(C(=O)Nc2ccc(C3(C#N)CC3)cc2)cc1OC",
        "output": "11"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)OCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl.CO.O=C([O-])[O-].[K+].[K+]>>Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CO)c3Cl)cccn2c1Br",
        "output": "687"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NCCCCn1cnc2c(N)nc3ccccc3c21.O=C(O)c1ccc2ncccc2c1>>Nc1nc2ccccc2c2c1ncn2CCCCNC(=O)c1ccc2ncccc2c1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)CCc1ccc(OCCOC)cc1Oc1ncc(Cl)cc1Cl.CCOCC.CO.Cc1ccccc1.O.[H-]>>COCCOc1ccc(CCCO)c(Oc2ncc(Cl)cc2Cl)c1",
        "output": "225"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COCCCc1ncccc1-c1ccc(C(CNC(=O)OC(C)(C)C)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)c(C)c1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.[Na+]>>COCCCc1c(-c2ccc(C(CNC(=O)OC(C)(C)C)Cc3ccc(OCCOc4c(Cl)cc(C)cc4Cl)cc3)c(C)c2)ccc[n+]1[O-]",
        "output": "262"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[O-].COCCOc1cc2nccc(Cl)c2cc1C#N.CS(C)=O.Cc1cc(F)c(O)cc1OCc1ccccc1.O.O=C([O-])O.[K+].[Na+]>>COCCOc1cc2nccc(Oc3cc(OCc4ccccc4)c(C)cc3F)c2cc1C#N",
        "output": "351"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NCC(=O)N1CCC(Oc2ccccc2Cl)CC1.O.O=C(O)c1ccc(-c2nnco2)cc1.On1nnc2ccccc21>>O=C(NCC(=O)N1CCC(Oc2ccccc2Cl)CC1)c1ccc(-c2nnco2)cc1",
        "output": "718"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#CCOc1ccc(C(=O)Cl)cc1F.CCCC(C)N>>C#CCOc1ccc(C(=O)NC(C)CCC)cc1F",
        "output": "271"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)OB(c2ccc(N)nc2)OC1(C)C.FC(F)(F)c1cc(-c2ccc(Cl)c(Cl)c2)nc(-c2cccc(Br)c2)n1>>Nc1ccc(-c2cccc(-c3nc(-c4ccc(Cl)c(Cl)c4)cc(C(F)(F)F)n3)c2)cn1",
        "output": "954"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1cc2nc(-c3ccnc(-c4cccc(C#N)c4)c3)sc2c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>Cc1cc2nc(-c3ccnc(-c4cccc(-c5nnn[nH]5)c4)c3)sc2c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C",
        "output": "390"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1ccc2c(c1)[nH]c(=S)n2NC(=O)c1ccc(Cl)c(S(N)(=O)=O)c1.Cl.[Na+].[OH-]>>NS(=O)(=O)c1cc(C(=O)Nn2c(=S)[nH]c3cc(C(=O)O)ccc32)ccc1Cl",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCO.Clc1ccc2ncc(-c3cc4ccccc4o3)n2n1.NC[C@@H](O)c1ccccc1.[Cl-].[NH4+]>>O[C@H](CNc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1",
        "output": "241"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(C)c(C(O)c2c(C)cncc2Br)c(OC)c1OC.Cc1ccccc1.[Mn+4].[O-2].[O-2]>>COc1cc(C)c(C(=O)c2c(C)cncc2Br)c(OC)c1OC",
        "output": "59"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCOc1ccc2c(c1)C(c1ccc(OC)cc1OCOC)C(CO)C2c1ccc2c(c1)OCO2.CS(=O)(=O)Cl.ClCCl>>CCCOc1ccc2c(c1)C(c1ccc(OC)cc1OCOC)C(COS(C)(=O)=O)C2c1ccc2c(c1)OCO2",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CO.Cc1cnn(CCC2CCN(C(=O)OC(C)(C)C)CC2)c1.Cl>>Cc1cnn(CCC2CCNCC2)c1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.NNc1ccc(S(N)(=O)=O)cc1.O=Cc1ccc(Cl)cc1>>NS(=O)(=O)c1ccc(NN=Cc2ccc(Cl)cc2)cc1",
        "output": "167"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1cc2c(n1CC#N)CC(F)(F)CC2.[BH4-].[Na+]>>CCOC(=O)c1cc2c(n1CCN)CC(F)(F)CC2",
        "output": "246"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCc1c(OCCCOc2ccc([N+](=O)[O-])cc2)ccc2c1OC(CCC(=O)OCC)(CCC(=O)OCC)CC2=O.CCO.[Ni]>>CCCc1c(OCCCOc2ccc(N)cc2)ccc2c1OC(CCC(=O)OCC)(CCC(=O)OCC)CC2=O",
        "output": "202"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=C(O)c1ccc2c(c1)Sc1ccc(S)cc1C=C2.O=C(O)c1ccc2c(c1)Sc1ccccc1CC2>>OCc1ccc2c(c1)Sc1ccc(S)cc1C=C2",
        "output": "72"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CC[C@H](N)[C@H](c2ccc(Cl)c(Cl)c2)C1.CCN(CC)CC.Cc1ccc(S(=O)(=O)O)cc1.O.O=C(Cl)c1ccc(Cl)cc1>>CC(C)(C)OC(=O)N1CC[C@H](NC(=O)c2ccc(Cl)cc2)[C@H](c2ccc(Cl)c(Cl)c2)C1",
        "output": "271"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.Clc1ncc(Br)cn1.NCC1CCN(C(=O)[C@@H]2C[C@H]2c2ccccc2)CC1.O=C(O)C(F)(F)F.O=C([O-])[O-].[Cs+].[Cs+]>>O=C([C@@H]1C[C@H]1c1ccccc1)N1CCC(CNc2ncc(Br)cn2)CC1",
        "output": "544"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCCOCCOc1ccc(-c2ccc(N(C)Cc3cnn(C)c3)c(/C=C/C(=O)OCC)c2)cc1.CO.Cl.O.[Na+].[OH-]>>CCCCOCCOc1ccc(-c2ccc(N(C)Cc3cnn(C)c3)c(/C=C/C(=O)O)c2)cc1",
        "output": "122"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1ccc(Nc2nccc(-c3ccc(C(=O)NCCc4ccccc4)s3)n2)cc1.ClCCl>>O=C(NCCc1ccccc1)c1ccc(-c2ccnc(Nc3ccc(O)cc3)n2)s1",
        "output": "402"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)/C(F)=C(/C)c1cc2c(cc1OCC)OC(C)(C)C=C2c1ccccc1.[H-]>>CCOc1cc2c(cc1/C(C)=C(/F)CO)C(c1ccccc1)=CC(C)(C)O2",
        "output": "150"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(C)=O.OCCn1cc(-c2ccncc2)c(-c2ccc(OCc3ccccc3)cc2)n1.[Pd]>>OCCn1cc(-c2ccncc2)c(-c2ccc(O)cc2)n1",
        "output": "23"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)O.CC=C(C)C.O.O=Cc1c(F)cc(Br)cc1[N+](=O)[O-].[Na+].[O-][Cl+][O-]>>O=C(O)c1c(F)cc(Br)cc1[N+](=O)[O-]",
        "output": "384"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN.CS(C)=O.Nc1nc(Cl)ccc1C(=O)NCc1ccn(Cc2cccc(F)c2)c1.O.[Cl-].[Na+]>>CNc1ccc(C(=O)NCc2ccn(Cc3cccc(F)c3)c2)c(N)n1",
        "output": "70"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)Cn1nc(C(C)=O)c2cc(OCc3ccccc3)ccc21.[Pd]>>COC(=O)Cn1nc(C(C)=O)c2cc(O)ccc21",
        "output": "23"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#C[C@]1(O)CCN(C)C1=O.CCOC(=O)c1nn(-c2cccc(Br)c2)c2c1CN(C(=O)C1CC1)CC2>>CCOC(=O)c1nn(-c2cccc(C#C[C@]3(O)CCN(C)C3=O)c2)c2c1CN(C(=O)C1CC1)CC2",
        "output": "659"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(C)=O.O.O=[N+]([O-])c1ccc(CCl)cc1.[H-].[Na+].c1ccc2[nH]ccc2c1>>O=[N+]([O-])c1ccc(Cn2ccc3ccccc32)cc1",
        "output": "556"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cc(CNc2ccccc2C(=O)NOCC2CCCC2)ccc1F.O.[Li+].[OH-]>>O=C(O)c1cc(CNc2ccccc2C(=O)NOCC2CCCC2)ccc1F",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CC(=O)C12CCCCC1c1ccccc1C2=O.CO>>O=C(CBr)C12CCCCC1c1ccccc1C2=O",
        "output": "173"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NCc1ccco1.O=Cc1cccs1>>c1coc(CNCc2cccs2)c1",
        "output": "691"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.CC(=S)NC[C@H]1CN(c2ccc(N)c(F)c2)C(=O)O1.ClCCl.c1ccncc1>>CC(=O)Nc1ccc(N2C[C@H](CNC(C)=S)OC2=O)cc1F",
        "output": "6"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCN(c2cc(-c3ccc4c(c3)CNCC4)nc(N)n2)CC1.Cl.O=C(Cl)Cc1ccc(F)cc1>>CN1CCN(c2cc(-c3ccc4c(c3)CN(C(=O)Cc3ccc(F)cc3)CC4)nc(N)n2)CC1",
        "output": "240"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COCCCN1C(=O)CCc2ccc(COC3CN(C(=O)OC(C)(C)C)CCC3c3ccc(O)cc3)cc21.N#Cc1ccccc1OCCCCBr>>COCCCN1C(=O)CCc2ccc(COC3CN(C(=O)OC(C)(C)C)CCC3c3ccc(OCCCCOc4ccccc4C#N)cc3)cc21",
        "output": "75"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(F)c(Cl)c1.CS(C)=O.Cc1c(O)cccc1Cl.O=C([O-])[O-].[Cs+].[Cs+]>>COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(Oc2cccc(Cl)c2C)c(Cl)c1",
        "output": "727"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)c1nc(CC(C)(C)c2ccccc2)nc(O)c1OCc1ccccc1.Cl.O.O.O.[Li+].[OH-]>>CC(C)(Cc1nc(O)c(OCc2ccccc2)c(C(=O)O)n1)c1ccccc1",
        "output": "569"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cl.O.O=C(NCCCBr)OCC1c2ccccc2-c2ccccc21.O=C(O)c1ccccc1S.[Na+].[OH-]>>O=C(NCCCSc1ccccc1C(=O)O)OCC1c2ccccc2-c2ccccc21",
        "output": "124"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CCC(NC(=O)OCc1ccccc1)C(=O)NC(CC(C)C)C(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)C([NH3+])CCC(=O)NCCCN=[N+]=[N-].On1nnc2ccccc21.[Cl-]>>C#CCC(NC(=O)OCc1ccccc1)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)NCCCN=[N+]=[N-])C(=O)OC",
        "output": "129"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O.O=C(O)CCNc1ccc(Cl)nn1.OCc1ccccc1.[H-].[Na+]>>O=C(O)CCNc1ccc(OCc2ccccc2)nn1",
        "output": "407"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)C(=O)N1CCC(CCO[Si](C)(C)C(C)(C)C)(c2ccccc2)OC1.CCCC[N+](CCCC)(CCCC)CCCC.O=C([O-])O.[F-].[Na+]>>CC(C)(C)C(=O)N1CCC(CCO)(c2ccccc2)OC1",
        "output": "708"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)c1ccccc1.COc1cc(N2CCN(C)CC2)ccc1Nc1nc(Oc2cc(F)cc([N+](=O)[O-])c2)c2c(Cl)cn(COCC[Si](C)(C)C)c2n1.O=P(Cl)(Cl)Cl>>COc1cc(N2CCN(C)CC2)ccc1Nc1nc(Oc2cc(N)cc(F)c2)c2c(Cl)cn(COCC[Si](C)(C)C)c2n1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)c1nc(CCCOCc2ccccc2)n(C)c1Sc1cc(Cl)cc(Cl)c1.Cl.O=C([O-])O.[Na+]>>CC(C)c1nc(CCCO)n(C)c1Sc1cc(Cl)cc(Cl)c1",
        "output": "178"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)CCCc1ccc(Br)cc1.Cc1noc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)c1NC(=O)OC(C)c1ccccc1Cl.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1>>CCOC(=O)CCCc1ccc(-c2ccc(-c3onc(C)c3NC(=O)OC(C)c3ccccc3Cl)cc2)cc1",
        "output": "933"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C(=O)OC(C)(C)C)C1CCC(Oc2ncnc3sc4c(c23)[C@@H](CC(N)=O)CC4)CC1.Cl.ClCCl>>CNC1CCC(Oc2ncnc3sc4c(c23)[C@@H](CC(N)=O)CC4)CC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(N)cc1C(F)(F)F.Fc1cnc(Cl)nc1Cl>>Cc1ccc(Nc2nc(Cl)ncc2F)cc1C(F)(F)F",
        "output": "352"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2)C1(C#N)c1ccc(Cl)cc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CNC.ClCCl.F[P-](F)(F)(F)(F)F>>CN(C)C(=O)C1NC(CC(C)(C)C)C(C#N)(c2ccc(Cl)cc2)C1c1cccc(Cl)c1",
        "output": "685"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)[C@@H](N)[C@H]2SC1.COc1ccccc1.Cc1ccccc1.O=C(O)C(F)(F)F>>COC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1",
        "output": "228"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCOc1ccc(C=O)cc1.CO.COc1cc(OC)cc(C(C)=O)c1.[Na+].[OH-]>>CCCCOc1ccc(/C=C/C(=O)c2cc(OC)cc(OC)c2)cc1",
        "output": "656"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN.ClCCl.N#Cc1ncc(N2C(=O)C3(CCC3)N(c3ccc(CCCC(=O)O)cc3)C2=S)cc1C(F)(F)F.O.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1>>CNC(=O)CCCc1ccc(N2C(=S)N(c3cnc(C#N)c(C(F)(F)F)c3)C(=O)C23CCC3)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.FC(F)(F)c1ccc2[nH]ccc2c1.[BH3-]C#N.[Na+]>>FC(F)(F)c1ccc2c(c1)CCN2",
        "output": "672"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)/C(CC(=O)O)=C(\\c1ccc(Cl)cc1)c1ccc(S(C)(=O)=O)cc1.O.[Na+].[OH-]>>CS(=O)(=O)c1ccc(/C(=C(\\CC(=O)O)C(=O)O)c2ccc(Cl)cc2)cc1",
        "output": "122"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.CCSCC(O)(C(Nc1cccc2nc(C)ccc12)c1ccc(OC)c(F)c1Cl)C(F)(F)F.ClCCl>>CCSCC(O)(C(Nc1cccc2nc(C)ccc12)c1ccc(O)c(F)c1Cl)C(F)(F)F",
        "output": "207"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.O.O=C(O)C1CCCN1C(=O)OCc1ccccc1.O=C([O-])O.[K+]>>COC(=O)C1CCCN1C(=O)OCc1ccccc1",
        "output": "415"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOc1ccc(Cn2c3c(c4cc(C(=O)N5CCC(C)CC5)ccc42)CNCC3)cc1.O=C(O)C(F)(F)F.O=C1CCOCC1>>CCOc1ccc(Cn2c3c(c4cc(C(=O)N5CCC(C)CC5)ccc42)CN(C2CCOCC2)CC3)cc1",
        "output": "187"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)C.CC(C)C[Al+]CC(C)C.CC[Al](CC)CC.Cl.N#Cc1ccccc1-c1ccc(CO)cc1.O=N[O-].[N-]=[N+]=[N-].[Na+]>>OCc1ccc(-c2ccccc2-c2nnn[nH]2)cc1",
        "output": "390"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)[C@H](Cc1ccc(OC/C=C(\\C)c2ccc(-c3cc(Cl)cc(Cl)c3)cc2)cc1)OCC.[Na+].[OH-]>>CCO[C@@H](Cc1ccc(OC/C=C(\\C)c2ccc(-c3cc(Cl)cc(Cl)c3)cc2)cc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(C)=O.NC(=O)c1ccc(C(F)(F)F)cc1[N+](=O)[O-].[Pd]>>NC(=O)c1ccc(C(F)(F)F)cc1N",
        "output": "486"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(CC(O)CN)CC1.CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.CN(C)C=O.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C.F[P-](F)(F)(F)(F)F.O.O=C([O-])O.[Na+]>>COc1cc(C(=O)NCC(O)CN2CCN(C(=O)OC(C)(C)C)CC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CO[C@@H]1[C@H](O)[C@@H](CO[Si](OC(c2ccccc2)c2ccccc2)(O[Si](C)(C)C)O[Si](C)(C)C)O[C@H]1n1ccc(=O)[nH]c1=O.ClCCl>>CO[C@@H]1[C@H](OC(C)=O)[C@@H](CO[Si](OC(c2ccccc2)c2ccccc2)(O[Si](C)(C)C)O[Si](C)(C)C)O[C@H]1n1ccc(=O)[nH]c1=O",
        "output": "254"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1C(=O)COc2nc(-c3ccc(CNC(=O)OC(C)(C)C)cc3)c(-c3ccccc3)cc21.O=C(O)C(F)(F)F>>CN1C(=O)COc2nc(-c3ccc(CN)cc3)c(-c3ccccc3)cc21",
        "output": "793"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C#N)CCCc2ccccc21.CS(C)=O.O.O=C([O-])[O-].OO.[K+].[K+]>>CC1(C(N)=O)CCCc2ccccc21",
        "output": "632"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NC1CCNCC1.O=[N+]([O-])c1cc(C(F)(F)F)ccc1F>>CC(C)(C)OC(=O)NC1CCN(c2ccc(C(F)(F)F)cc2[N+](=O)[O-])CC1",
        "output": "26"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cl.Fc1ccc2[nH]cc(CCCBr)c2c1.NCC1COc2ccccc2O1>>Fc1ccc2[nH]cc(CCCNCC3COc4ccccc4O3)c2c1",
        "output": "147"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)CC1(c2ccccc2)CC1c1ccc(OCCc2ccc3c(n2)NCCC3)cc1.[Na+].[OH-]>>O=C(O)CC1(c2ccccc2)CC1c1ccc(OCCc2ccc3c(n2)NCCC3)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)CC(NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1.CO.[C].[H][H].[Pd]>>CC(C)CC(NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br.c1ccc(C(=C(c2ccccc2)c2ccccc2)c2ccccc2)cc1>>Brc1ccc(C(=C(c2ccccc2)c2ccccc2)c2ccccc2)cc1",
        "output": "4"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)c1c(OCc2ccccc2)ccc(Oc2c(C)cc([N+](=O)[O-])c3c2CCC3)c1O.CC[SiH](CC)CC.ClCCl.O.O=C(O)C(F)(F)F>>CCc1c(OCc2ccccc2)ccc(Oc2c(C)cc([N+](=O)[O-])c3c2CCC3)c1O",
        "output": "92"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(Cl)Cl.Cc1cccc(C)c1C.ClCCl.Cl[Sn](Cl)(Cl)Cl>>Cc1ccc(C=O)c(C)c1C",
        "output": "591"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.ClCC1CO1.O.Oc1cccc2ccccc12.[Na+].[OH-]>>c1ccc2c(OCC3CO3)cccc2c1",
        "output": "15"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCON.CO.CON=C(C(=O)OC)c1ccccc1COc1cccc(C(C)=O)c1.Cl>>CCCCON=C(C)c1cccc(OCc2ccccc2C(=NOC)C(=O)OC)c1",
        "output": "212"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)c1[nH]c(C)c(C)c1C(C)=O.[K+].[OH-]>>CC(=O)c1c(C(=O)O)[nH]c(C)c1C",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCOCC.ClCCl.OCCCn1ncc2cc(Br)ccc21.c1c[nH]cn1>>CC(C)(C)[Si](OCCCn1ncc2cc(Br)ccc21)(c1ccccc1)c1ccccc1",
        "output": "602"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(Cc1cccc(-c2cnc(N3CCN(c4ncc(CO)cc4Cl)CC3)nc2)c1)C(=O)CNC(=O)OC(C)(C)C.ClCCl.[Mn+4].[O-2].[O-2]>>CN(Cc1cccc(-c2cnc(N3CCN(c4ncc(C=O)cc4Cl)CC3)nc2)c1)C(=O)CNC(=O)OC(C)(C)C",
        "output": "520"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.Clc1ncc(Br)c(Cl)n1.NC(=O)C1CCNCC1.O=C([O-])O.[Na+]>>NC(=O)C1CCN(c2nc(Cl)ncc2Br)CC1",
        "output": "296"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1ccccc1O.Cl[Cu]Cl.Clc1ccccc1.II>>CCc1cc(I)ccc1O",
        "output": "372"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.Clc1nc(Cl)c2ccccc2n1.Nc1ccccc1F.O.O=C([O-])[O-].[K+].[K+]>>Fc1ccccc1Nc1nc(Cl)nc2ccccc12",
        "output": "352"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Br.Nc1cc(Cl)c(F)c(Cl)c1F.O.O=N[O-].[Na+]>>Fc1c(Cl)cc(Br)c(F)c1Cl",
        "output": "373"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)CN([C@@H](CCCCN)C(=O)O)S(=O)(=O)c1ccc([N+](=O)[O-])cc1.COc1cccc(C=CC(=O)O)c1OC>>COc1cccc(C=CC(=O)NCCCC[C@@H](C(=O)O)N(CC(C)C)S(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1OC",
        "output": "549"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)COc1cc2c3c(sc2c(Cl)c1Cl)CCCC3.Cl.[Na+].[OH-]>>O=C(O)COc1cc2c3c(sc2c(Cl)c1Cl)CCCC3",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.N#Cc1cc(C=O)ccc1-n1cnc([N+](=O)[O-])n1.O=C([O-])[O-].[Br-].[K+].[K+]>>C=Cc1ccc(-n2cnc([N+](=O)[O-])n2)c(C#N)c1",
        "output": "649"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)S(=O)(=O)c1ccc(-c2cncc(-c3cc(-c4ccc(CN(C)C(=O)OC(C)(C)C)cc4)no3)n2)cc1.ClCCl.O=C(O)C(F)(F)F>>CNCc1ccc(-c2cc(-c3cncc(-c4ccc(S(=O)(=O)C(C)C)cc4)n3)on2)cc1",
        "output": "887"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.Cc1nnc(-c2ccc(Cl)c([N+](=O)[O-])c2)[nH]1.Cl[Sn](Cl)(Cl)Cl>>Cc1nnc(-c2ccc(Cl)c(N)c2)[nH]1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCCCBr.CC(C)=O.CCCc1c(OCCCC(=O)OCC)ccc(C(C)=O)c1O.O=C([O-])[O-].[K+].[K+]>>CCCc1c(OCCCC(=O)OCC)ccc(C(C)=O)c1OCCCBr",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1cccc(C(C)C)c1N=C=O.CN(C)C=O.Cn1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccc(Oc3ccc4cccc(N)c4c3)cc21>>CC(C)c1cccc(C(C)C)c1NC(=O)Nc1cccc2ccc(Oc3ccc4nc(COc5ccc(CC6SC(=O)NC6=O)cc5)n(C)c4c3)cc12",
        "output": "473"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.C1COCCO1.CC(=O)N1CCc2c(c(Nc3ccc(-c4cn(COCC[Si](C)(C)C)nc4C(F)F)cc3F)nn2C2CCOC2)C1.Cl>>CC(=O)N1CCc2c(c(Nc3ccc(-c4c[nH]nc4C(F)F)cc3F)nn2C2CCOC2)C1",
        "output": "813"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCN(C(C)C)C(C)C.N#Cc1cc(-c2ncnc(Cl)n2)ccc1OC1CCOCC1.Nc1ccc(N2CCS(=O)(=O)CC2)cc1>>N#Cc1cc(-c2ncnc(Nc3ccc(N4CCS(=O)(=O)CC4)cc3)n2)ccc1OC1CCOCC1",
        "output": "592"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](n2ccc3c(NC(=O)c4ccccc4)ncnc32)O[C@@H]1COS(N)(=O)=O.c1ccncc1.c1ccncc1>>NS(=O)(=O)OC[C@H]1O[C@@H](n2ccc3c(NC(=O)c4ccccc4)ncnc32)C[C@@H]1O",
        "output": "708"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCO.N#CCc1ccc(N)cc1>>CC(C)(C)OC(=O)Nc1ccc(CC#N)cc1",
        "output": "735"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN(CCO[Si](C)(C)C(C)(C)C)C(=O)c1nc(CC2(c3ccccn3)CCCC2)nc(O)c1OCc1ccccc1.Cl>>CN(CCO)C(=O)c1nc(CC2(c3ccccn3)CCCC2)nc(O)c1OCc1ccccc1",
        "output": "708"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(CCOCCOCCOCCC(=O)OC(C)(C)C)Cc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)n1.ClCCl.O=C(O)C(F)(F)F>>CN(CCOCCOCCOCCC(=O)O)Cc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)n1",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C#N)c1cccc2c(-c3ccccc3)onc12.CCO.O.[Na+].[OH-]>>CC(C(=O)O)c1cccc2c(-c3ccccc3)onc12",
        "output": "259"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "B.C1CCOC1.CO.COB(OC)OC.CSC.O=C(O)c1cccnc1Nc1ccccc1>>OCc1cccnc1Nc1ccccc1",
        "output": "293"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.Nc1ccc(Br)cc1.O=C(Cl)c1c(F)cccc1F.c1ccncc1>>O=C(Nc1ccc(Br)cc1)c1c(F)cccc1F",
        "output": "11"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1cccc2ccncc12.O=C(O)c1ccc(-c2ccccc2)cc1>>O=C(Nc1cccc2ccncc12)c1ccc(-c2ccccc2)cc1",
        "output": "50"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccccc1-c1ccsc1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>BrCc1ccccc1-c1ccsc1",
        "output": "29"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)S(=O)(=O)c1ccccc1Nc1nc(Cl)ncc1Cl.COc1cc2c(cc1N)CCN(CC(=O)N1CCN(C)CC1)CC2>>COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)N(C)C)n1)CCN(CC(=O)N1CCN(C)CC1)CC2",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].O.O=C(O)c1c(F)ccc(O)c1[N+](=O)[O-].[Na+]>>O=C(O)c1c(F)cc(Br)c(O)c1[N+](=O)[O-]",
        "output": "98"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOc1cc(OCc2ccc(OC)cc2)ncc1-c1ccc(CC(=O)O)c(F)c1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1nnc(-c2cc(N)cc(C(F)(F)F)c2)o1.ClCCl.F[P-](F)(F)(F)(F)F>>CCOc1cc(OCc2ccc(OC)cc2)ncc1-c1ccc(CC(=O)Nc2cc(-c3nnc(C)o3)cc(C(F)(F)F)c2)c(F)c1",
        "output": "365"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)C(CNC(=O)OC(C)(C)C)Cc1cccnc1.CO.[Li+].[OH-]>>CC(C)(C)OC(=O)NCC(Cc1cccnc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)N(CCOS(C)(=O)=O)Sc1ccccc1.CS(C)=O.Oc1ccc(O)cc1.Oc1ccc(Oc2cc(F)cc(F)c2)cc1.c1ccncc1>>CCOC(=O)N(CCOc1ccc(Oc2cc(F)cc(F)c2)cc1)Sc1ccccc1",
        "output": "702"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#C[Si](C)(C)C.CC#N.COc1cc(Br)ccc1I.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1>>COc1cc(Br)ccc1C#C[Si](C)(C)C",
        "output": "826"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.Nc1c(I)c(C(=O)Cl)c(I)c(C(=O)Cl)c1I.O.O=C(Cl)CCl>>O=C(CCl)Nc1c(I)c(C(=O)Cl)c(I)c(C(=O)Cl)c1I",
        "output": "9"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrBr.CC(=O)O.CC(=O)c1ccc(I)cc1F>>O=C(CBr)c1ccc(I)cc1F",
        "output": "173"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COC(=O)c1cccc(OCc2nc3ccc(Oc4ncccc4Cl)cc3n2C)c1.[Na+].[OH-]>>Cn1c(COc2cccc(C(=O)O)c2)nc2ccc(Oc3ncccc3Cl)cc21",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)COc1ccc(CC(C)=O)cc1.FC(F)(F)c1nc(C2CNCCO2)cs1>>COC(=O)COc1ccc(CC(C)N2CCOC(c3csc(C(F)(F)F)n3)C2)cc1",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCNCC1.F[P-](F)(F)(F)(F)F.O=C(O)c1cncc(Br)c1>>CN1CCN(C(=O)c2cncc(Br)c2)CC1",
        "output": "256"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CS(=O)(=O)Oc1cccc(C2CCNCC2)c1F.O=C([O-])[O-].OCCI.Oc1c(OC(F)(F)F)cccc1C1CCNCC1.[K+].[K+]>>OCCN1CCC(c2cccc(OC(F)(F)F)c2O)CC1",
        "output": "184"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cc(Br)c(-c2cccc(Cl)c2)s1.N#Cc1cccc(-c2cc(C(=O)O)sc2-c2cc(F)cc(Cl)c2)c1>>O=C(O)c1cc(Br)c(-c2cccc(Cl)c2)s1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1nnn(C)c1-c1cnc2c3ccc(C4(O[Si](C)(C)C(C)(C)C)COC4)cc3n([C@H](c3ccc(F)cc3)C3CCOCC3)c2c1.[F-]>>Cc1nnn(C)c1-c1cnc2c3ccc(C4(O)COC4)cc3n([C@H](c3ccc(F)cc3)C3CCOCC3)c2c1",
        "output": "708"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N(Cc1cccc(C2CCNCC2)c1)C(=O)OC(C)(C)C.ClCCl.O=C=Nc1ccc(Cl)c(Cl)c1>>CC(C)(C)OC(=O)N(Cc1cccc(C2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)c1)C(=O)OC(C)(C)C",
        "output": "323"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.CCOc1ccc(CC(=O)OC)cc1O.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.OCCCc1cn(-c2ccc(C(F)(F)F)cn2)nc1C1CCCCC1>>CCOc1ccc(CC(=O)O)cc1OCCCc1cn(-c2ccc(C(F)(F)F)cn2)nc1C1CCCCC1",
        "output": "928"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CCN1CCCCC1.CCN(CC)CC.CN(C)C=O.COC(=O)COc1ccc(OCC#Cc2cc(Br)cc(Br)c2)cc1C.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COC(=O)COc1ccc(OCC#Cc2cc(Br)cc(C#CCN3CCCCC3)c2)cc1C",
        "output": "659"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1cc(Br)ccc1OCc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[K+].[Pd].[Pd]>>Cc1cc(B2OC(C)(C)C(C)(C)O2)ccc1OCc1ccccc1",
        "output": "942"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCOCc1ccccc1.CN(C)C=O.Nc1cc[nH]n1.O.O=C([O-])O.[Cl-].[H-].[Na+].[Na+].[Na+]>>Nc1ccn(CCCOCc2ccccc2)n1",
        "output": "577"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc(NC(=O)C(=O)c2c(C)n(Cc3ccc(Cl)cc3)c3ccc(CO)cc23)ccn1.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>COc1cc(NC(=O)C(=O)c2c(C)n(Cc3ccc(Cl)cc3)c3ccc(C=O)cc23)ccn1",
        "output": "179"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.Cl.O.O=C(N[C@H](CO)C12CC(C(F)(F)F)(C1)C2)[C@@H]1C[C@H]2C[C@H]2N1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OC[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1)C12CC(C(F)(F)F)(C1)C2",
        "output": "193"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@@H](Cc1ccc(F)cc1F)C(=O)O.CC(C)(C)[Si](C)(C)Cl.CCCCCC.CCOC(C)=O.CN(C)C=O.CO.O.O=C([O-])[O-].[K+].[K+].c1c[nH]cn1>>CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@H](C[C@@H](Cc1ccc(F)cc1F)C(=O)O)O[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.COc1cc2c(Oc3ccc(N)cc3)ccnc2cc1C#N.Cc1ccccc1.O=C=Nc1ccc(F)cc1>>COc1cc2c(Oc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)ccnc2cc1C#N",
        "output": "912"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(N)cc1-n1ccn2nc(-c3cccnc3)cc12.O=C(O)c1cccc(S(F)(F)(F)(F)F)c1>>COc1ccc(NC(=O)c2cccc(S(F)(F)(F)(F)F)c2)cc1-n1ccn2nc(-c3cccnc3)cc12",
        "output": "817"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.NC(=O)c1c(C(F)(F)F)ccc(Cl)c1Cl.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>N#Cc1c(C(F)(F)F)ccc(Cl)c1Cl",
        "output": "374"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCOC(=O)CCCCCBr.Cc1ccccc1.Cl.Clc1cccc(N2CCNCC2)c1>>CCOC(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCC=O.CO.Cl.[BH4-].[Na+]>>CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCCO",
        "output": "223"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CS(C)=O.Fc1ccc(-c2cc(C3CCCNC3)n(-c3ncccn3)n2)cc1.O=S(=O)(Cl)c1c(F)cccc1F>>O=S(=O)(c1c(F)cccc1F)N1CCCC(c2cc(-c3ccc(F)cc3)nn2-c2ncccn2)C1",
        "output": "99"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)c1snc(C(N)=O)c1N.O.[Na+].[OH-]>>NC(=O)c1nsc(C(=O)O)c1N",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3C(=O)OC)cc2)n1.CCO.[Na+].[OH-]>>CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)n1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1ccc2[nH]c(-c3cc(N4CCC(C(=O)O)C4)ccc3Cl)nc2c1.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+]>>Cc1ccc2[nH]c(-c3cc(N4CCC(C(=O)N5CCOCC5)C4)ccc3Cl)nc2c1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1ccc(C2CCC(=O)CC2)cc1.O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1>>COC(=O)c1ccc(C2CCC(N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1",
        "output": "187"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Cc1nc2c(o1)c(C(=O)O)cc1nc(Nc3c(Cl)cccc3Cl)[nH]c12.Nc1ccc(F)cc1.O=S(Cl)Cl.[H-].[Na+].c1ccccc1>>Cc1nc2c(o1)c(C(=O)Nc1ccc(F)cc1)cc1nc(Nc3c(Cl)cccc3Cl)[nH]c12",
        "output": "799"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl.OC(CC1CCN(Cc2ccccc2)CC1)c1ccccc1Cl>>O=C(CC1CCN(Cc2ccccc2)CC1)c1ccccc1Cl",
        "output": "32"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1ccc(-n2nccn2)c(C(=O)O)n1.FC(F)(F)c1ccc(OC[C@@H]2C[C@H]3C[C@H]3CN2)nc1.F[B-](F)(F)F>>Cc1ccc(-n2nccn2)c(C(=O)N2C[C@@H]3C[C@@H]3C[C@H]2COc2ccc(C(F)(F)F)cn2)n1",
        "output": "605"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)[C@H](N)C(=O)OCc1ccccc1.CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.Cl.Cl.O.O=C(O)Cc1cccc(OC(F)(F)F)c1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CC(C)[C@H](NC(=O)Cc1cccc(OC(F)(F)F)c1)C(=O)OCc1ccccc1",
        "output": "132"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(CN)c1cnc(-c2ccccc2)s1.O=C(O)c1cccc(-c2noc(C(F)(F)F)n2)c1>>CC(C)(CNC(=O)c1cccc(-c2noc(C(F)(F)F)n2)c1)c1cnc(-c2ccccc2)s1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COCCOc1ccc(N2CCN(CCN3C(=O)N(C)N4C5=C(c6ccco6)N=CN(N)C5=NC34)CC2)cc1.ClCCl>>CN1C(=O)N(CCN2CCN(c3ccc(OCCO)cc3)CC2)C2N=C3C(=C(c4ccco4)N=CN3N)N21",
        "output": "423"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.CCN(CC)CC.CN(C)c1nc(Cl)nc2ccccc12.Cl.NCc1ccc(NC(=O)c2ccc(-c3ccccc3)cc2)cc1>>CN(C)c1nc(NCc2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2)nc2ccccc12",
        "output": "364"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[C@H]1C(=O)[C@@]2(C)[C@H]([C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](N)c4ccccc4)C(C)=C1C3(C)C)[C@]1(OC(C)=O)CO[C@@H]1C[C@@H]2O.CCCCC.CCOC(C)=O.CO.ClC(Cl)Cl.O=C(Cl)c1ccccc1.O=C([O-])O.[Na+]>>CC(=O)O[C@H]1C(=O)[C@@]2(C)[C@H]([C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C(C)=C1C3(C)C)[C@]1(OC(C)=O)CO[C@@H]1C[C@@H]2O",
        "output": "411"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)CN(c1ccc2c(c1)CCN2C(=O)Nc1ccccc1)S(=O)(=O)c1cc(Cl)cc(Cl)c1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)CN(c1ccc2c(c1)CCN2C(=O)Nc1ccccc1)S(=O)(=O)c1cc(Cl)cc(Cl)c1",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(N)COc1cccc2c1C(N)=NS(=O)(=O)N2.Cl.N#Cc1cc(C(=O)O)ccn1>>CC(C)(COc1cccc2c1C(N)=NS(=O)(=O)N2)NC(=O)c1ccnc(C#N)c1",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)c1cccc(C(C)C)c1-n1c(-c2cccc(B3OC(C)(C)C(C)(C)O3)c2)nc2ccccc21.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.COc1cccc2oc3ccc(Cl)nc3c12.Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>COc1cccc2oc3ccc(-c4cccc(-c5nc6ccccc6n5-c5c(C(C)C)cccc5C(C)C)c4)nc3c12",
        "output": "955"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.COC(=O)c1ccc(NC(CC(C)C)c2oc3ccccc3c2C)cc1.[Na+].[OH-]>>Cc1c(C(CC(C)C)Nc2ccc(C(=O)O)cc2)oc2ccccc12",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.COCCC1CN(C(=O)OCc2ccccc2)CCN1.ClCCl.N#CBr>>COCCC1CN(C(=O)OCc2ccccc2)CCN1C#N",
        "output": "532"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(OC)c1nc2c(cc1C=O)CCCN2.ClCCl.[BH4-].[Na+]>>COC(OC)c1nc2c(cc1CO)CCCN2",
        "output": "476"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrC(Br)(Br)Br.CC#N.C[Si](C)(C)CCOCOc1cc2ccccc2cc1CO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C[Si](C)(C)CCOCOc1cc2ccccc2cc1CBr",
        "output": "750"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)NCCc1ccccc1.Cl.O=C(Cl)c1ccccc1.O=[N+]([O-])c1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)NCCc1ccc(C(=O)c2ccccc2)cc1",
        "output": "61"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.ClCCCl.FC(F)(F)c1ccc2c(S)ccnc2c1.O.O=C([O-])[O-].[Br-].[K+].[K+].[K+].[OH-]>>FC(F)(F)c1ccc2c(SCCCl)ccnc2c1",
        "output": "460"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCN(CCC)CCCCN(Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1)C(=O)OC(C)(C)C.CO.CO.Cl>>CCCN(CCC)CCCCNCc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1",
        "output": "887"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CC(C)(O)CNc1c(N)c(Cl)nc2ccccc12.COCCC(=O)Cl>>COCCC(=O)Nc1c(Cl)nc2ccccc2c1NCC(C)(C)O",
        "output": "422"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)COc1ccc(-c2cccc3c2c(C)c(-c2ccccc2)n3Cc2ccccc2)cc1.[K+].[OH-]>>Cc1c(-c2ccccc2)n(Cc2ccccc2)c2cccc(-c3ccc(OCC(=O)O)cc3)c12",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CSCC[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.ClCCl.F[P-](F)(F)(F)(F)F.Nc1ccc(OCc2ccccc2)cc1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CSCC[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc(OCc2ccccc2)cc1",
        "output": "646"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(O)c1cc(C(=O)O)cc(S(F)(F)(F)(F)F)c1.Cc1ccc(N)cc1-n1ccn2nc(-c3cccnc3)cc12>>Cc1ccc(NC(=O)c2cc(C(C)(C)O)cc(S(F)(F)(F)(F)F)c2)cc1-n1ccn2nc(-c3cccnc3)cc12",
        "output": "50"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC[SiH](CC)CC.CCc1ccc2c(F)cc(F)cc2c1C=O.COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.O=C(O)C(F)(F)F>>CCc1ccc2c(F)cc(F)cc2c1CNC(=O)c1c(OC)cc(O)c2c1OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C",
        "output": "996"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cc(=O)c(OCc2ccccc2)cn1-c1cccc(-c2ccccc2)c1.Cl>>Cc1cc(=O)c(O)cn1-c1cccc(-c2ccccc2)c1",
        "output": "264"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NC1CCOC1.O=C(O)CN1C[C@@H]2COCCN2c2nc(Cl)ncc21>>O=C(CN1C[C@@H]2COCCN2c2nc(Cl)ncc21)NC1CCOC1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)NCCNS(=O)(=O)c1ccc(-c2cn(C(=O)OC(C)(C)C)c3cc(F)ccc23)cn1.NC1CCN(c2ccc(-c3c[nH]c4cc(F)ccc34)cn2)CC1>>CC(=O)NCCNS(=O)(=O)c1ccc(-c2c[nH]c3cc(F)ccc23)cn1",
        "output": "848"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.CCOC(OCC)OCC.Cc1cc(Cl)ccc1C(=O)O.O=S(=O)(O)O>>Cc1cc(Cl)ccc1CO",
        "output": "72"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCc1ccc(Cl)cc1-c1cc(Cl)nc(N)n1.Nc1ccc(CCO)cc1>>CCc1ccc(Cl)cc1-c1cc(Nc2ccc(CCO)cc2)nc(N)n1",
        "output": "161"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)C(=O)Cl.ClCCl.Nc1ccc(C#Cc2ccccc2)cn1.c1ccncc1>>CC(C)(C)C(=O)Nc1ccc(C#Cc2ccccc2)cn1",
        "output": "332"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.ClCCCBr.O=C([O-])[O-].Oc1ccc2c(c1)CCN(C1CCC1)CC2.[K+].[K+]>>ClCCCOc1ccc2c(c1)CCN(C1CCC1)CC2",
        "output": "75"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].CCCCC/C=C\\C/C=C\\CCCCCCCCOc1ccc(C=O)cc1OCCCCCCCC/C=C\\C/C=C\\CCCCC.CCO.CNC.Cl.ClCCl.N.[BH4-].[Na+].[Ti+4]>>CCCCC/C=C\\C/C=C\\CCCCCCCCOc1ccc(CN(C)C)cc1OCCCCCCCC/C=C\\C/C=C\\CCCCC",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN=C=NCCCN(C)C.CCOC(=O)c1ccc(NC(=O)CC(C(=O)O)c2ccccc2)cc1.Cc1ccccc1NC(=O)Nc1ccc(N)cc1.Cl.On1nnc2ccccc21>>CCOC(=O)c1ccc(NC(=O)CC(C(=O)Nc2ccc(NC(=O)Nc3ccccc3C)cc2)c2ccccc2)cc1",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CC[C@@H](O)[C@H]1C(=O)O.CCO.Cl.[BH4-].[Cl-].[Li+].[Na+]>>CC(C)(C)OC(=O)N1CC[C@@H](O)[C@H]1CO",
        "output": "218"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.Nc1ccc(-c2n[nH]c(=O)c3cccn23)cc1.O=C(Cl)Oc1ccccc1.c1ccncc1>>O=C(Nc1ccc(-c2n[nH]c(=O)c3cccn23)cc1)Oc1ccccc1",
        "output": "102"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.CSc1ccc(Br)cc1Cl.Cl.[Li]CCCC>>CSc1ccc(B(O)O)cc1Cl",
        "output": "832"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cn2ncnc(Oc3ccc([N+](=O)[O-])cc3F)c2c1C.CO.[Cl-].[NH4+].[Zn]>>CCOC(=O)c1cn2ncnc(Oc3ccc(N)cc3F)c2c1C",
        "output": "335"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CC(C)(C)OC(=O)N1CCC2(CC1)N=C(CN)NC2=O.CCN(CC)CC.ClCCl>>CC(=O)NCC1=NC2(CCN(C(=O)OC(C)(C)C)CC2)C(=O)N1",
        "output": "45"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.N.N#CCc1ccc(OC(F)(F)F)cc1.[H][H].[Ni]>>NCCc1ccc(OC(F)(F)F)cc1",
        "output": "246"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br.C1CCOC1.C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCCBr.O.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)OC(=O)NCCCBr",
        "output": "631"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cc1nc2cccc3nc(SCCCCCN4C(=O)c5ccccc5C4=O)c1n23.O>>Cc1nc2cccc3nc(SCCCCCN)c1n23",
        "output": "242"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(=O)N(C)C.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.COCCCN.COc1cc(Nc2nc3ccccc3nc2NS(=O)(=O)c2ccc(C(=O)O)cc2)cc(OC)c1.Cl.On1nnc2ccccc21>>COCCCNC(=O)c1ccc(S(=O)(=O)Nc2nc3ccccc3nc2Nc2cc(OC)cc(OC)c2)cc1",
        "output": "835"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COCCO.COCCOc1ccc(N)cc1Cl.O=[N+]([O-])c1ccc(F)c(Cl)c1>>COCCOc1ccc([N+](=O)[O-])cc1Cl",
        "output": "485"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CI.CN(C)S(=O)(=O)n1ccnc1CO.[Cl-].[H-].[NH4+].[Na+]>>COCc1nccn1S(=O)(=O)N(C)C",
        "output": "140"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cc1cc(C2CC2)c(C(O)c2nc3cc(C#N)cnc3[nH]2)c2ccn(C(=O)OC(C)(C)C)c12.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1cc(C2CC2)c(C(O)c2nc3cc(C#N)cnc3[nH]2)c2cc[nH]c12",
        "output": "848"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1nc(C(C)(N)C2CC2)no1.O=C(O)c1cc(OCC(F)(F)F)c(C2CC2)cn1>>Cc1nc(C(C)(NC(=O)c2cc(OCC(F)(F)F)c(C3CC3)cn2)C2CC2)no1",
        "output": "137"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CC(C)(C)O[Na].CC(C)(C)[O-].CC(C)=O.CCC(C)=O.CCOCC.CN(C)P(=O)(N(C)C)N(C)C.CN1CCCN(C)C1=O.CS(C)=O.ClCc1ccccc1.O=C([O-])O.O=C([O-])[O-].O=C([O-])[O-].O=S1(=O)CCCC1.Oc1ccc(F)c(F)c1F.[K+].[K+].[K+].[Na+].[Na+].[Na+]>>Fc1ccc(OCc2ccccc2)c(F)c1F",
        "output": "49"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(C)c(Br)c(C)n1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>Cc1cc(CBr)nc(C)c1Br",
        "output": "590"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CN1c2ccccc2Sc2ccc(CC(=O)O)cc21.Cc1ccccc1.O.O=C([O-])[O-].O=S(=O)(O)O.[Na+].[Na+]>>CCOC(=O)Cc1ccc2c(c1)N(C)c1ccccc1S2",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)CCCCl.CN(C)C=O.COC(=O)Cc1ccc2c(c1)C(=C1CCNCC1)c1sccc1CO2.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>COC(=O)Cc1ccc2c(c1)C(=C1CCN(CCCC(C)=O)CC1)c1sccc1CO2",
        "output": "138"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)c1cc([N+](=O)[O-])c(O)cc1C(F)(F)F.[C].[Pd]>>COC(=O)c1cc(N)c(O)cc1C(F)(F)F",
        "output": "481"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(CO)ccc1C.ClCCl.[Mn+2].[O-2]>>COc1cc(C=O)ccc1C",
        "output": "179"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CCC(C)(C)c1ccc(NC(C)=O)cc1.O=[N+]([O-])O>>CCC(C)(C)c1ccc(NC(C)=O)c([N+](=O)[O-])c1",
        "output": "21"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(N)c1ccccn1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl.O=C(O)c1cnc2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc2c1.On1nnc2ccccc21>>CCC(NC(=O)c1cnc2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc2c1)c1ccccn1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCOC(=O)CCNC(CO[Si](C)(C)C(C)(C)C)CC(=O)OCC.O=C(Cl)OCc1ccccc1.O=C([O-])O.[Na+]>>CCOC(=O)CCN(C(=O)OCc1ccccc1)C(CO[Si](C)(C)C(C)(C)C)CC(=O)OCC",
        "output": "427"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN1CC[NH+](C)C1Cl.Cc1nc(C(=O)O)c(C)n1-c1ccccc1.ClCCl.F[P-](F)(F)(F)(F)F.NC12CC3CC(C1)CC(O)(C3)C2>>Cc1nc(C(=O)NC23CC4CC(CC(O)(C4)C2)C3)c(C)n1-c1ccccc1",
        "output": "697"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.ClCCl.Nc1ccc(-c2ccc3c(c2)ncn3-c2ccc(OCCO)cc2)cc1.c1ccncc1>>CC(=O)Nc1ccc(-c2ccc3c(c2)ncn3-c2ccc(OCCO)cc2)cc1",
        "output": "6"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.ClC(Cl)Cl.O=Cc1cccc(O)c1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1cccc(C=O)c1",
        "output": "746"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC(CF)c1cccc(Cl)c1.Cl>>NC(CF)c1cccc(Cl)c1",
        "output": "793"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.CC(C)CC(CNC(=O)OC(C)(C)C)CC(=O)NCCC#N.COC(=O)C(CC(=O)OC(C)(C)C)CC(C)C.Cl>>CC(C)CC(CC(=O)OC(C)(C)C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Nc1cccc(C#C[Si](C)(C)C)n1.CO.O=C([O-])[O-].[K+].[K+]>>C#Cc1cccc(NC(C)=O)n1",
        "output": "337"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCCCCBr.CC(C)=O.O=C([O-])[O-].O=C(c1ccc(O)cc1)c1c(-c2ccccc2)oc2ccccc12.[K+].[K+]>>O=C(c1ccc(OCCCCBr)cc1)c1c(-c2ccccc2)oc2ccccc12",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1Oc1ccc(Br)cc1.CCO.O.[C-]#N.[Na+]>>N#CCc1ccccc1Oc1ccc(Br)cc1",
        "output": "39"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Cc1ncc(-c2ccc(-c3cnn(C)c3)cc2)c2[nH]c(=O)ccc12.O=P(Cl)(Cl)Cl>>Cc1ncc(-c2ccc(-c3cnn(C)c3)cc2)c2nc(Cl)ccc12",
        "output": "100"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)Cc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.Cc1noc(-c2ccc(Br)cc2)c1[C@H](O)CSCc1ccccc1>>CCOC(=O)Cc1ccc(-c2ccc(-c3onc(C)c3[C@H](O)CSCc3ccccc3)cc2)cc1",
        "output": "933"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCc1ccc(O)c(-c2cc(CC=C)ccc2O)c1.CN(C)C=O.ICCCCCCCCCCOC1CCCCO1.[H-].[H][H].[Na+]>>C=CCc1ccc(O)c(-c2cc(CC=C)ccc2OCCCCCCCCCCOC2CCCCO2)c1",
        "output": "198"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cc1ccc(Oc2cccc([N+](=O)[O-])c2)cc1.[Pd]>>Cc1ccc(Oc2cccc(N)c2)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.COCC(=O)Nc1cc(Oc2ccc([N+](=O)[O-])c3ccccc23)ccn1.O=C([O-])[O-].[Fe].[Na+].[Na+]>>COCC(=O)Nc1cc(Oc2ccc(N)c3ccccc23)ccn1",
        "output": "335"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1cnc(CBr)cn1.C[Si](C)(C)[O-].Cl.O.[K+]>>O=C(O)c1cnc(CBr)cn1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cccc(OC)c1P(C1CCCCC1)C1CCCCC1.C[C@@H]1CN(C(=O)C2CCC(F)(F)CC2)CCN1c1nnc(Cl)c2ccncc12.N#Cc1ccc(B(O)O)cc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd]>>C[C@@H]1CN(C(=O)C2CCC(F)(F)CC2)CCN1c1nnc(-c2ccc(C#N)cc2)c2ccncc12",
        "output": "866"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.Cc1cc2cc(C(=O)O)ccc2n1Cc1ccc(Cl)cc1>>Cc1cc2cc(CO)ccc2n1Cc1ccc(Cl)cc1",
        "output": "72"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN.O=S(=O)(Nc1cccc2c(Cl)ccnc12)c1ccccc1>>CNc1ccnc2c(NS(=O)(=O)c3ccccc3)cccc12",
        "output": "78"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC1(CO)COC(=O)N1.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.O.[Cl-].[Na+].c1ccncc1>>CCC1(COS(=O)(=O)c2ccc(C)cc2)COC(=O)N1",
        "output": "197"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C(O)c1ccccc1-n1cccc1.c1ccc(-c2ccnc(N3CC4CNCC4C3)n2)cc1>>O=C(c1ccccc1-n1cccc1)N1CC2CN(c3nccc(-c4ccccc4)n3)CC2C1",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.Cl.NS(=O)(=O)c1ccc(Oc2ccc(F)cc2F)c([N+](=O)[O-])c1.O.[Fe].[NH4+]>>Nc1cc(S(N)(=O)=O)ccc1Oc1ccc(F)cc1F",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.Nc1cc(F)ccc1F.c1ccncc1>>Cc1ccc(S(=O)(=O)Nc2cc(F)ccc2F)cc1",
        "output": "68"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N[C@H]1CC[C@@H]2CN(c3cccc(C(F)(F)F)c3)C[C@@H]21.Cl>>N[C@H]1CC[C@@H]2CN(c3cccc(C(F)(F)F)c3)C[C@H]12",
        "output": "538"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(Cl)OC(=O)Cl.COCCOCCOCCO.ClCCl.c1ccncc1>>COCCOCCOCCOC(=O)OC(C)Cl",
        "output": "144"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)c1ccc(Cl)cc1.Cc1cc(C=O)cc(C)c1O>>Cc1cc(C=CC(=O)c2ccc(Cl)cc2)cc(C)c1O",
        "output": "295"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "N[C@@H]1CCC[C@@H]1N1CCCC1.O=C(O)c1c(Cl)cc(C(F)(F)F)cc1Cl>>O=C(N[C@@H]1CCC[C@@H]1N1CCCC1)c1c(Cl)cc(C(F)(F)F)cc1Cl",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)[O-].CCOC(C)=O.CS(=O)(=O)C1CCN(c2cc(Cl)nc3ccsc23)CC1.Cl.N[C@H]1CCN(C(=O)Cc2ccc(OC(F)(F)F)cc2)C1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CS(=O)(=O)C1CCN(c2cc(N[C@H]3CCN(C(=O)Cc4ccc(OC(F)(F)F)cc4)C3)nc3ccsc23)CC1",
        "output": "70"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.Cl.OCCCc1cc(-c2ccc(C(F)(F)F)cc2)no1>>CS(=O)(=O)OCCCc1cc(-c2ccc(C(F)(F)F)cc2)no1",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O.Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1Oc1ccc([N+](=O)[O-])cn1.Cl.N.[Zn]>>Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1Oc1ccc(N)cn1",
        "output": "269"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.O=C1NC(=O)c2ccccc21.OCCCCC1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C1c2ccccc2C(=O)N1CCCCC1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1",
        "output": "420"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CN(CCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)C(=O)OC(C)(C)C.Cl.ClCCl>>CNCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COC(=O)c1ccc(-c2ccc(C#N)nc2)cc1.Cl.O.[Li+].[OH-]>>N#Cc1ccc(-c2ccc(C(=O)O)cc2)cn1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)c1cc(C=O)cc(C(C)C)c1N.CO.ClCCl.O.[BH4-].[Na+]>>CC(C)c1cc(CO)cc(C(C)C)c1N",
        "output": "356"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)c1ccccc1B(O)O.O[C@H]1CCc2cc(Br)ccc21>>CC(C)c1ccccc1-c1ccc2c(c1)CC[C@@H]2O",
        "output": "837"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nccc(-c2ccc(Cl)nc2)n1.NC1CCCC1.O>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nccc(-c2ccc(NC3CCCC3)nc2)n1",
        "output": "70"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCN(C)CCCCCc1ccc2c(ccn2C(=O)OC(C)(C)C)c1.CCO.O.[Na+].[OH-]>>C=CCN(C)CCCCCc1ccc2[nH]ccc2c1",
        "output": "848"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCBr.O=C(O)c1cccc2ccccc12>>CCCCCOC(=O)c1cccc2ccccc12",
        "output": "416"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)CC(=O)Cl.Cc1cc(Nc2ncnc3cnc(F)cc23)ccc1OC1CCN(C(=O)C2CCCC2)CC1.Cc1cc(Nc2ncnc3cnc(N4CCOCC4)cc23)ccc1OC1CCNCC1>>Cc1cc(Nc2ncnc3cnc(N4CCOCC4)cc23)ccc1OC1CCN(C(=O)CC(C)(C)C)CC1",
        "output": "125"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1c(C)cc(N2CCC(C(=O)OC)CC2)nc1C.CO.[Na+].[OH-]>>CCOC(=O)c1c(C)cc(N2CCC(C(=O)O)CC2)nc1C",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.Cl.N#Cc1cccc(-c2csc(N)n2)c1.c1ccncc1>>Cc1ccc(S(=O)(=O)Nc2nc(-c3cccc(C#N)c3)cs2)cc1",
        "output": "637"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(=O)Cl.N#CC=C1CCN(c2ccc(N3C[C@H](CN)OC3=O)cc2F)CC1.c1ccncc1>>CCC(=O)NC[C@H]1CN(c2ccc(N3CCC(=CC#N)CC3)c(F)c2)C(=O)O1",
        "output": "45"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(O)C(=O)Nc1cc2c(cc1F)CC(=O)N2.Cc1c(C=O)[nH]c2c1C(=O)N(CCN1CCCC1)CC2>>Cc1c(C=C2C(=O)Nc3cc(NC(=O)C(C)(C)O)c(F)cc32)[nH]c2c1C(=O)N(CCN1CCCC1)CC2",
        "output": "440"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#Cc1ccccc1NCCCl.C1CCOC1.CC#N.CCOC(C)=O.CNC.O=C([O-])[O-].[I-].[Na+].[Na+].[Na+]>>C#Cc1ccccc1NCCN(C)C",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)O)cn2)c1O.NCCCCO>>Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)NCCCCO)cn2)c1O",
        "output": "674"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=[N+]([O-])c1ccc2c(c1)CCNCC2>>O=C(N1CCc2ccc([N+](=O)[O-])cc2CC1)C(F)(F)F",
        "output": "397"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)CN1CCc2nn(-c3cccnc3)cc2C1=O.CO.Cl.[Na+].[OH-]>>O=C(O)CN1CCc2nn(-c3cccnc3)cc2C1=O",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cl.O.O=[N+]([O-])c1ccc(S(=O)(=O)Nc2cc(-c3ccccc3)ncn2)cc1.[Fe]>>Nc1ccc(S(=O)(=O)Nc2cc(-c3ccccc3)ncn2)cc1",
        "output": "401"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)Cc1ccc(NC(=O)Nc2ccccc2C)c(OC)c1.[Na+].[OH-]>>COc1cc(CC(=O)O)ccc1NC(=O)Nc1ccccc1C",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.Nc1cccc(NC(=O)c2cccc(C(F)(F)F)c2)c1.O=CO>>O=CNc1cccc(NC(=O)c2cccc(C(F)(F)F)c2)c1",
        "output": "27"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCCS(C)(=O)=O)c1=O.NCCCN1CCCC1=O>>CS(=O)(=O)CCCn1c(=O)c(C(=O)NCCCN2CCCC2=O)c(O)c2ncc(Cc3ccc(F)cc3)cc21",
        "output": "498"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CCOC(C)=O.COc1cc(Br)cc(C)c1N.Cl.O.O=N[O-].O=[PH2]O.[Na+]>>COc1cc(C)cc(Br)c1",
        "output": "324"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)OC(=O)CCCCc1cc2cc(CO)ccc2c(=O)n1-c1ccc(F)cc1.ClCCl.O=S([O-])([O-])=S.[Na+].[Na+]>>CC(C)(C)OC(=O)CCCCc1cc2cc(C=O)ccc2c(=O)n1-c1ccc(F)cc1",
        "output": "179"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1ccccc1N(C)C.[BH4-].[Na+]>>CN(C)c1ccccc1CO",
        "output": "444"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O=Cc1ccc(-c2nc3nccn3cc2-c2ccccc2)cc1.c1ccc2nc(C3CCNCC3)cnc2c1>>c1ccc(-c2cn3ccnc3nc2-c2ccc(CN3CCC(c4cnc5ccccc5n4)CC3)cc2)cc1",
        "output": "567"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)CCc1ccc(N)cc1.Cl.Cl[Sn]Cl.O.O.O=N[O-].[Na+]>>CCOC(=O)CCc1ccc(NN)cc1",
        "output": "109"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1cc(-n2cc(NC(N)=O)c(C(N)=O)n2)ccc1I.Fc1ccc(S)cc1.N#N.OCCO.[Cu]I>>Cc1cc(-n2cc(NC(N)=O)c(C(N)=O)n2)ccc1Sc1ccc(F)cc1",
        "output": "565"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCOC(=O)/N=N/C(=O)OCC.N#Cc1ccc(O)cc1.O=C1C=C(OCCCCCCO)c2ccccc2C1=O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1ccc(OCCCCCCOC2=CC(=O)C(=O)c3ccccc32)cc1",
        "output": "478"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1c(CO)nc(-c2ccc(F)cc2)n1CC[C@@H]1C[C@H](CC(=O)OC(C)(C)C)OC(C)(C)O1.CCOC(C)=O.ClCCl.[Mn+4].[O-2].[O-2]>>CC(C)c1c(C=O)nc(-c2ccc(F)cc2)n1CC[C@@H]1C[C@H](CC(=O)OC(C)(C)C)OC(C)(C)O1",
        "output": "287"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCBr.CCC(C)=O.CCCCCC.CCOC(C)=O.O=C([O-])[O-].OCc1ccc(O)cc1.[K+].[K+]>>C=CCOc1ccc(CO)cc1",
        "output": "77"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.Cl[Pd]Cl.Clc1ccccc1-n1ncnc1-c1cn2c(n1)-c1cc(Br)ccc1OCC2.O.O=C([O-])[O-].OB(O)c1ccc(Cl)cc1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Clc1ccc(-c2ccc3c(c2)-c2nc(-c4ncnn4-c4ccccc4Cl)cn2CCO3)cc1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)Nc1ccc(-c2ccnc3[nH]ccc23)cc1.Cl.ClCCl>>Nc1ccc(-c2ccnc3[nH]ccc23)cc1",
        "output": "782"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC(C)=O.CCCC[N+](CCCC)(CCCC)CCCC.COCOc1ccc(C2COc3cc(OCOC)ccc3C2(O)c2ccc(OCCOCCCl)cc2)cc1.[I-].[I-].[Na+]>>COCOc1ccc(C2COc3cc(OCOC)ccc3C2(O)c2ccc(OCCOCCI)cc2)cc1",
        "output": "97"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)O.CC1C(=O)CC2(C)CCC1C2.[BH4-].[Na+]>>CC1C(O)CC2(C)CCC1C2",
        "output": "91"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1cccc(-n2c(C)ccc2-c2ccccc2O)c1.CN(C)C=O.Fc1ccc(CBr)c(Cl)c1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cccc(-n2c(C)ccc2-c2ccccc2OCc2ccc(F)cc2Cl)c1",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(C)=O.CSc1cc(-c2ccco2)nc(C(=O)NCc2ccc(F)cc2)c1OCc1ccccc1.O.O=S([O-])OO.[K+]>>CS(=O)(=O)c1cc(-c2ccco2)nc(C(=O)NCc2ccc(F)cc2)c1OCc1ccccc1",
        "output": "730"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "NCCN1CCCC1.O=C1CCC2(CC1)OCCO2>>C1CCN(CCNC2CCC3(CC2)OCCO3)C1",
        "output": "236"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCOC1CC(NC[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H](N)Cc2ccccc2)c2cc(Oc3ccccc3)ccc21.C=CCO[C@@H]1C[C@H](NC[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)c2cc(Br)ccc21.C=CC[C@@H](C(=O)O)N(C)C(=O)CCCCC>>C=CCOC1CC(NC[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](Cc2ccccc2)NC(=O)[C@H](CC=C)N(C)C(=O)CCCCC)c2cc(Oc3ccccc3)ccc21",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(CNCC(F)(F)F)(COCc2ccccc2)CC1.CO.Cl.[Pd]>>CC(C)(C)OC(=O)N1CCC(CO)(CNCC(F)(F)F)CC1",
        "output": "178"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CCOP(=O)(CO)OCC.CN(C)c1ccccn1.ClCCl.O>>CCOP(=O)(CO[Si](C)(C)C(C)(C)C)OCC",
        "output": "193"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.OC(C1CCCCC1)C1CCC(F)(F)CC1>>O=C(C1CCCCC1)C1CCC(F)(F)CC1",
        "output": "87"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(CC)CC.CN.CN(C)C=O.COc1ccc(CCNc2cc(-c3cccc(S(=O)(=O)Cl)c3)nc(OC)n2)cc1.O>>CNS(=O)(=O)c1cccc(-c2cc(NCCc3ccc(OC)cc3)nc(OC)n2)c1",
        "output": "43"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)C1(NC(=O)OC(C)(C)C)CC1CCO.CS(=O)(=O)Cl.ClCCl>>COC(=O)C1(NC(=O)OC(C)(C)C)CC1CCOS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.COc1cn[nH]c1-c1cc(C(=O)O)ccc1C.Cl.Cl.N#Cc1ccc(C2CNC2)cc1>>COc1cn[nH]c1-c1cc(C(=O)N2CC(c3ccc(C#N)cc3)C2)ccc1C",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1cccc(OCCN2CCCC2)c1.[H][H].[Pd]>>Nc1cccc(OCCN2CCCC2)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1c(CN)c(=O)c2ccc(C(F)(F)F)nc2n1-c1ccccc1.Cl.O=C(O)c1ccc(-c2ccn[nH]2)cc1>>COC(=O)c1c(CNC(=O)c2ccc(-c3ccn[nH]3)cc2)c(=O)c2ccc(C(F)(F)F)nc2n1-c1ccccc1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cl.Cl.NCC1CCCC(F)(F)C1.O=C(O)c1cc(C2CCOC2)n2cccc(Cl)c12.On1nnc2ccccc21>>O=C(NCC1CCCC(F)(F)C1)c1cc(C2CCOC2)n2cccc(Cl)c12",
        "output": "674"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Nc1ncnc2[nH]ccc(=O)c12.O=C1CCC(=O)N1I>>Nc1ncnc2[nH]cc(I)c(=O)c12",
        "output": "783"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CN(Cc1cn2c(F)cccc2n1)C1CCCc2cccnc21>>CN(Cc1cn2c(N3CCN(C(=O)OC(C)(C)C)CC3)cccc2n1)C1CCCc2cccnc21",
        "output": "756"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[C@H](N)CO.O=C(O)c1nn(-c2cnccn2)c2c1C[C@@H]1C[C@H]21>>CC(C)(C)[C@@H](CO)NC(=O)c1nn(-c2cnccn2)c2c1C[C@@H]1C[C@H]21",
        "output": "816"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CNCCO.Cc1nc2c(OC3CCOc4cc(F)cc(F)c43)cc(C(=O)O)cc2[nH]1>>Cc1nc2c(OC3CCOc4cc(F)cc(F)c43)cc(C(=O)N(C)CCO)cc2[nH]1",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)N1Cc2nc(Cl)nc(N3CCOC[C@@H]3C)c2C1.CCNC(=O)Nc1ccc(B2OC(C)(C)C(C)(C)O2)c(F)c1.CCO.COCCOC.ClCCl.Cl[Pd]Cl.O.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CN(C(C)=O)C3)c(F)c1",
        "output": "974"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1ccc2[nH]ccc2c1.C=Cc1ccccc1.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.[Pd+2]>>C(=Cc1ccc2[nH]ccc2c1)c1ccccc1",
        "output": "539"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CCOC(C)=O.CO.COc1ccc2c(C)cc(Cl)nc2c1.Cc1ccccc1.N[C@H]1C[C@H]2C[C@H](N(Cc3ccccc3)C(=O)OCc3ccccc3)[C@@H]1C2.[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COc1ccc2c(C)cc(N[C@H]3C[C@H]4C[C@H](N(Cc5ccccc5)C(=O)OCc5ccccc5)[C@@H]3C4)nc2c1",
        "output": "70"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CCOC(C)=O.CN.O=C(CN1CCOCC1)c1ccc(-c2ccccc2)cc1.[BH3-]C#N.[Na+]>>CNC(CN1CCOCC1)c1ccc(-c2ccccc2)cc1",
        "output": "693"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.O=C(O)c1ccc(CCl)cc1>>CC(C)OC(=O)c1ccc(CCl)cc1",
        "output": "33"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccnc(COC(C)=O)c1C.Cc1ccccc1.[Na+].[OH-]>>COc1ccnc(CO)c1C",
        "output": "348"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1c2ccccc2-c2nc3ccc(Cl)cc3c3cc(O)cc1c23.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CN1c2ccccc2-c2nc3ccc(Cl)cc3c3cc(OS(=O)(=O)C(F)(F)F)cc1c23",
        "output": "731"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(B(O)O)cc1.Cc1c(C(N)=O)[nH]c2c(Br)cc(F)cc12>>COc1ccc(-c2cc(F)cc3c(C)c(C(N)=O)[nH]c23)cc1",
        "output": "833"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCC1CO1.CCOC(C)=O.CN(C)C=O.N#Cc1cc2c(Oc3ccc(N)c(F)c3)ccnc2cc1O.O.O=C([O-])[O-].[K+].[K+]>>N#Cc1cc2c(Oc3ccc(N)c(F)c3)ccnc2cc1OCC1CO1",
        "output": "18"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C(C)=O)cc1OC.Cc1ccccc1.O=C([O-])[O-].[Cl-].[Cl-].[Fe].[Na+].[Na+].[Ru+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(C(C)O)cc1OC",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CSc1cccc(NS(=O)(=O)c2ccc(F)cc2[N+](=O)[O-])c1.Cl[Sn]Cl>>CSc1cccc(NS(=O)(=O)c2ccc(F)cc2N)c1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1c(C)c[nH]c1CC(=O)NCC1(O)CCN(C)CC1.Cl.[Na+].[OH-]>>CCOC(=O)c1c(C)c[nH]c1CCNCC1(O)CCN(C)CC1",
        "output": "112"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.Cc1ncc2n1C(=O)N(C1CCN(C(=O)[C@H](N)CS(=O)(=O)c3ccc4cc(Cl)ccc4c3)CC1)C2.ClCCl.O=C([O-])O.[Na+]>>CC(=O)N[C@H](CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)C(=O)N1CCC(N2Cc3cnc(C)n3C2=O)CC1",
        "output": "159"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.C[Si](C)(C)CCOCCl.O=c1[nH]nc(Cl)cc1Br.[H-].[Na+]>>C[Si](C)(C)CCOCn1nc(Cl)cc(Br)c1=O",
        "output": "910"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CSCOC(=O)Cn1nc(C(F)(F)F)cc1-c1ccc(-c2cccc(S(C)(=O)=O)c2)[nH]1.O=C1CCC(=O)N1Br>>CSCOC(=O)Cn1nc(C(F)(F)F)c(Br)c1-c1ccc(-c2cccc(S(C)(=O)=O)c2)[nH]1",
        "output": "620"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(=O)CC(N)C(F)(F)F.Cl>>CCOC(=O)CC(NC(=O)OC(C)(C)C)C(F)(F)F",
        "output": "631"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1ccc(-c2ccnc(NC3CCCCC3)c2)nc1N1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1ccc(-c2ccnc(NC3CCCCC3)c2)nc1N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc2c(Oc3ccc(/C=C/C(C)=O)cc3)c(-c3ccccc3C(C)C)sc2c1.ClCCl>>CC(=O)/C=C/c1ccc(Oc2c(-c3ccccc3C(C)C)sc3cc(O)ccc23)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc2c(ccc3cnn(CC(C)N)c32)c1.C[S+](C)[B-](Br)(Br)Br.ClCCCl.O=C([O-])O.[Na+]>>CC(N)Cn1ncc2ccc3cc(O)ccc3c21",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.O=[N+]([O-])c1ccc(NCc2ccccn2)nc1.[Pd]>>Nc1ccc(NCc2ccccn2)nc1",
        "output": "269"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCNCC.Cl.ClCCCCOc1ccccc1/C=C/c1nc2ccccc2o1>>CCN(CC)CCCCOc1ccccc1/C=C/c1nc2ccccc2o1",
        "output": "138"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Cl.Fc1ccc(C2CCC3(CC2)OCCO3)cc1>>O=C1CCC(c2ccc(F)cc2)CC1",
        "output": "251"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Nc1ccc(Sc2ccc3ccccc3c2)c(Cl)c1.O=S(=O)(Cl)c1ccc(I)cc1.c1ccncc1>>O=S(=O)(Nc1ccc(Sc2ccc3ccccc3c2)c(Cl)c1)c1ccc(I)cc1",
        "output": "68"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCOC(=O)c1ncccc1NC1COC1.O=C1CCC(=O)N1Br>>CCOC(=O)c1nc(Br)ccc1NC1COC1",
        "output": "779"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN.CCOC(=O)CN[C@H](C(=O)N1CC(c2cc(F)ccc2F)=C[C@H]1c1ccccc1)C(C)(C)C>>CCNC(=O)CN[C@H](C(=O)N1CC(c2cc(F)ccc2F)=C[C@H]1c1ccccc1)C(C)(C)C",
        "output": "64"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)c1cccc(Sc2c(C3CC3)n(-c3cnn(CCCC(=O)O)c3)c3c(F)c(Cl)ccc23)c1F.CN(C)C=O.CN1CCOCC1.Cl.O.On1nnc2ccccc21.[Cl-].[NH4+]>>CCOC(=O)c1cccc(Sc2c(C3CC3)n(-c3cnn(CCCC(N)=O)c3)c3c(F)c(Cl)ccc23)c1F",
        "output": "313"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)[N-]C(C)C.O.O=[N+]([O-])c1cc(C(F)(F)F)c(Br)cc1F.OCCCl.[Li+]>>O=[N+]([O-])c1cc(C(F)(F)F)c(Br)cc1OCCCl",
        "output": "485"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)n1nc(N)c2cc(C(=O)OC(C)(C)C)sc21.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(N2CCOCC2)cc1.O=C([O-])O.[Na+].c1ccncc1>>CCOC(=O)n1nc(NC(=O)c2ccc(N3CCOCC3)cc2)c2cc(C(=O)OC(C)(C)C)sc21",
        "output": "917"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N1CCNCC1.O=C1c2c(-c3ccc(F)cc3)cc(Cl)nc2OCCCN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CC(=O)N1CCN(c2cc(-c3ccc(F)cc3)c3c(n2)OCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)CC1",
        "output": "220"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1cc(O[Si](C)(C)C(C)(C)C)ccc1Br.ClCCl.Cl[Pd]Cl.[Fe+2].[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1cc(O[Si](C)(C)C(C)(C)C)ccc1B1OC(C)(C)C(C)(C)O1",
        "output": "942"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3n[nH]c4ccc(OC(F)F)cc34)nc12.CN(C)C=O.COC(=O)CCCBr.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)CCCn1nc(-c2cnc3c(n2)c(C(=O)NC(C)(C)C)cn3COCC[Si](C)(C)C)c2cc(OC(F)F)ccc21",
        "output": "577"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)C(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CSc1cccc(Oc2ncc(F)cc2C(=O)N[C@H]2CC[C@@H](N)CC2)c1.Cl.Cl.On1nnc2ccccc21>>CSc1cccc(Oc2ncc(F)cc2C(=O)N[C@H]2CC[C@@H](NC(=O)C(C)(C)C)CC2)c1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.NCCCn1cncn1.O.O=C(O)C1=Cc2c(ncnc2Nc2ccc(Oc3cccc(C(F)(F)F)c3)c(Cl)c2)NCC1.On1nnc2ccccc21>>O=C(NCCCn1cncn1)C1=Cc2c(ncnc2Nc2ccc(Oc3cccc(C(F)(F)F)c3)c(Cl)c2)NCC1",
        "output": "549"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1ccc(Cl)c(F)c1O.CC(C)=O.CI.O=C([O-])[O-].[K+].[K+]>>COc1c(C(C)=O)ccc(Cl)c1F",
        "output": "62"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1nncc2c1cnn2-c1ccc(F)cc1.CCOC(C)=O>>O=C(O)c1nncc2c1cnn2-c1ccc(F)cc1",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCCC.CCOC(C)=O.CN(C)c1ccncc1.Cc1c(Cl)ccc2c(N3CCNCC3)ccnc12.O=C=Nc1ccc(F)cc1>>Cc1c(Cl)ccc2c(N3CCN(C(=O)Nc4ccc(F)cc4)CC3)ccnc12",
        "output": "323"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.CCO.Cc1cccc(C)c1B(O)O.ClCCl.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])O.O=C([O-])[O-].O=c1[nH]cnc2ccc(Br)cc12.[K+].[K+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cccc(C)c1-c1ccc2nc[nH]c(=O)c2c1",
        "output": "837"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O.O=S([O-])S(=O)[O-].O=[N+]([O-])c1cc(Cn2ccnc2)ccc1NC1CCCCC1.[Na+].[Na+]>>Nc1cc(Cn2ccnc2)ccc1NC1CCCCC1",
        "output": "71"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOCC.COc1cccc(C2=C(COC=O)C(=O)N(C)CC2)c1.COc1cccc([C@]23CCN(C)C(=O)[C@H]2CCC2(C3)OCCO2)c1.[Cl-].[Na+]>>COc1cccc([C@]23CCN(C)C(=O)[C@H]2CCC(=O)C3)c1",
        "output": "251"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C2=C(C)NC(=O)CC2)cc1.Cc1cc(C)nc(C)c1.[I-].[Li+]>>CC1=C(c2ccc(O)cc2)CCC(=O)N1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C.CN1CCCC1=O.COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1.Cl.O=C(O)CS.[Na+].[OH-]>>CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.Nc1cc(F)c(Cl)cc1F.O=C1CCC(=O)N1Br>>Nc1c(F)cc(Cl)c(F)c1Br",
        "output": "4"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(O)C1CCN(Cc2ccc3nc(Cl)nc(N4CCOCC4)c3n2)CC1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.FC(F)(F)Cc1nc2ccccc2[nH]1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>CC(C)(O)C1CCN(Cc2ccc3nc(-n4c(CC(F)(F)F)nc5ccccc54)nc(N4CCOCC4)c3n2)CC1",
        "output": "788"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Cl.CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CNC3)cc1>>CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CN(C(C)=O)C3)cc1",
        "output": "125"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(CC(=O)O)c1ccccc1.Nn1nc(-c2ccc(Br)cc2)c2ccccc2c1=O>>CC(C)(CC(=O)Nn1nc(-c2ccc(Br)cc2)c2ccccc2c1=O)c1ccccc1",
        "output": "459"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(C)=O.Nc1cc(Cl)ccn1.O.Oc1ccc2[nH]ccc2c1.[H-].[Na+]>>Nc1cc(Oc2ccc3[nH]ccc3c2)ccn1",
        "output": "351"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C(CC#N)C4CCC(CO)C4)c3)ncnc21.ClCCl.NCCN.O=C(O)C(F)(F)F>>N#CCC(C1CCC(CO)C1)n1cc(-c2ncnc3[nH]ccc23)cn1",
        "output": "897"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(C(=O)NC2CCN(c3nc(Nc4ccc(OC)c(OC)n4)c4ncsc4n3)C2)cc1.Cl.O.[Li]O>>COc1ccc(Nc2nc(N3CCC(NC(=O)c4ccc(C(=O)O)cc4)C3)nc3scnc23)nc1OC",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCOS(C)(=O)=O.CCOC(C)=O.CN(C)C=O.COc1cc([N+](=O)[O-])ccc1O.O=C([O-])[O-].[K+].[K+]>>COc1cc([N+](=O)[O-])ccc1OCCNC(=O)OC(C)(C)C",
        "output": "702"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc2c(c1)C(CC(=O)O)C(=O)N2.NC(=O)c1cc(-c2cccnc2[C@@H](N)Cc2cc(F)cc(F)c2)ccc1F.O=C(O)C(F)(F)F>>COc1ccc2c(c1)C(CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)c1ncccc1-c1ccc(F)c(C(N)=O)c1)C(=O)N2",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccccn1.CN1CCOCC1.CNCC1CCN(Cc2ccccc2)C1.Cl.O.O=C(O)C(O)(c1ccccc1)C1CCCC1.Oc1cccc2[nH]nnc12>>CN(CC1CCN(Cc2ccccc2)C1)C(=O)C(O)(c1ccccc1)C1CCCC1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)c1ccc(N)cc1.O=Cc1ccc(F)cc1>>CC(C)c1ccc(NCc2ccc(F)cc2)cc1",
        "output": "359"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)C1CC1(F)c1ccccc1F.CO.[K]>>O=C(O)C1CC1(F)c1ccccc1F",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCN(CCC2CNCCO2)CC1.Cc1scc2c1N(C(=O)Cl)c1ccccc1NC2=O.Cl>>Cc1scc2c1N(C(=O)N1CCOC(CCN3CCCCC3)C1)c1ccccc1NC2=O",
        "output": "258"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(Cl)n2)s1.CS(=O)(=O)CCN>>CC(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(NCCS(C)(=O)=O)n2)s1",
        "output": "544"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)N.CC(C)(C)N.CCN(C(C)C)C(C)C.CCOCC.Cl.Cl.ClCCl.O=C(Cl)CCBr>>CC(C)(C)NC(=O)CCBr",
        "output": "45"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cccc(-n2c(C)ccc2-c2cc(Cl)ccc2O)c1.CCOC(C)=O.CN(C)C=O.Fc1ccc(CBr)cc1.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cccc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2)c1",
        "output": "127"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrBr.CC(=O)O.O.O=C1CCCCc2ccc(F)cc21>>O=C1c2cc(F)ccc2CCCC1Br",
        "output": "82"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CCOCC.CO.Cl.N#Cc1ccc(C=O)cc1.NO.[Na+]>>N#Cc1ccc(C=NO)cc1",
        "output": "30"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOCC1.CC(C)(C)O.CCCCCC.CN(C)C=O.Cl.N#Cc1ccc(-c2ccc(O)cc2)cc1.O.OCCCCCCBr.[Br-].[H-].[K+]>>N#Cc1ccc(-c2ccc(OCCCCCCO)cc2)cc1",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)c1cc(C(=O)N2CCCC(c3ccccc3F)C2)ccn1.CN(C)c1cc(C(=O)O)ccn1.Cc1cc(Cl)ccc1C1CCCNC1.Cl.Cl>>Cc1cc(Cl)ccc1C1CCCN(C(=O)c2ccnc(N(C)C)c2)C1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CN(CCCNc1ncnc2[nH]c(=O)[nH]c12)C(=O)OC(C)(C)C.Cl>>CNCCCNc1ncnc2[nH]c(=O)[nH]c12",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCBr.CCOC(=O)c1ccc(O)c(O)c1.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1ccc(OCC)c(O)c1",
        "output": "385"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)O.CCN=C=NCCCN(C)C.ClCCl.N[C@H]1CC[C@@H]2CN(Cc3ccccc3)C[C@H]12.O.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@H]1CC[C@@H]2CN(Cc3ccccc3)C[C@@H]21",
        "output": "216"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.O.O=C(CBr)c1ccc(Cl)cc1.OCC(O)c1ccc(Cl)cc1.c1ccccc1>>Clc1ccc(C2COC(CBr)(c3ccc(Cl)cc3)O2)cc1",
        "output": "93"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(c1ccccc1)n1nnc(-c2ccccc2-c2ccc(C=O)cc2)n1.CCO.O.[BH4-].[Na+]>>CC(C)(c1ccccc1)n1nnc(-c2ccccc2-c2ccc(CO)cc2)n1",
        "output": "356"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Cc1cccc(C)c1C(=O)O.O=S(Cl)Cl.c1ccncc1>>COC(=O)c1c(C)cccc1C",
        "output": "33"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.COc1cc(OCCCl)c2c(=O)[nH]cnc2c1.ClCCCl.O=P(Cl)(Cl)Cl>>COc1cc(OCCCl)c2c(Cl)ncnc2c1",
        "output": "14"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)C.Cl.O.O.[Li+].[OH-]>>CN(C)S(=O)(=O)c1cc([N+](=O)[O-])ccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C(CO)NC(=O)c1nsc2ccc(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)cc12.CCOCC.O=S(Cl)Cl>>CC(C)C(CCl)NC(=O)c1nsc2ccc(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)cc12",
        "output": "96"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.COC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OCc1ccccc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>COC(=O)[C@@H]1C[C@@H](OS(=O)(=O)c2ccc(C)cc2)CN1C(=O)OCc1ccccc1",
        "output": "197"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNCC1.COc1cccc(C2(CO)CCN(c3ccccc3OC)CC2)c1.Cc1ccc(S(=O)(=O)Cl)cc1.[Cl-].[NH4+].c1ccncc1>>COc1cccc(C2(CN3CCCCC3)CCN(c3ccccc3OC)CC2)c1",
        "output": "371"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.CO.ClC(Cl)Cl.Clc1ccc(C2CCNCC2)cc1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)c1nc(N2CCN(CCCCNC(=O)N3CCC(c4ccc(Cl)cc4)CC3)CC2)cc(C(F)(F)F)n1",
        "output": "734"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)O.CCOc1cc(N2CCC(N3CCN(S(C)(=O)=O)CC3)CC2)ccc1N.CCOc1ccc(-c2nc3ccccn3c2-c2ccnc(Cl)n2)cc1C(=O)Nc1c(F)cccc1F.Cc1ccc(S(=O)(=O)O)cc1>>CCOc1cc(N2CCC(N3CCN(S(C)(=O)=O)CC3)CC2)ccc1Nc1nccc(-c2c(-c3ccc(OCC)c(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1",
        "output": "808"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Cl.Cn1nc(C#N)cc1[N+](=O)[O-].O.[Fe]>>Cn1nc(C#N)cc1N",
        "output": "684"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2COC(C)C2)c2nc(C)nn12.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(C2COC(C)C2)c2nc(C)nn12",
        "output": "979"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.COc1cccc(C2CCCN2CCN2C(=O)c3ccccc3C2=O)c1>>O=C1c2ccccc2C(=O)N1CCN1CCCC1c1cccc(O)c1",
        "output": "732"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1cc(-n2nc(C)n(C(F)F)c2=O)c(Br)cc1Br.ClCCl>>Cc1nn(-c2cc(O)c(Br)cc2Br)c(=O)n1C(F)F",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@@H]1NCC[C@@H]1C(C)(C)O.Cc1cc(C#N)c(Cl)c(Cl)c1F.O=C([O-])[O-].[Li+].[Li+]>>Cc1cc(C#N)c(Cl)c(Cl)c1N1CC[C@H](C(C)(C)O)[C@@H]1C",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CI.CN(C)C=O.Clc1ccc(-c2nc[nH]c2-c2ccc(Cl)cc2Cl)c(Cl)c1.[H-].[Na+]>>Cn1cnc(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1Cl",
        "output": "404"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(NC[C@H]1NC[C@H]2C[C@H]21)c1cccc2occc12.O=C(O)c1nccnc1-c1ccccc1>>O=C(NC[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)c1nccnc1-c1ccccc1)c1cccc2occc12",
        "output": "729"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Cl.Cl[Sn]Cl.O.O.O=C(Nc1cccc([N+](=O)[O-])c1)c1ccc(F)cc1Cl.[NH4+].[OH-]>>Nc1cccc(NC(=O)c2ccc(F)cc2Cl)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCCC1C(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.Nc1cccc(-c2ccc(Cl)cc2)c1>>CC(C)(C)OC(=O)N1CCCC1C(=O)Nc1cccc(-c2ccc(Cl)cc2)c1",
        "output": "563"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1ncnc2ccc(-c3cccc(C(=O)O)c3)nc12>>CNC(=O)c1cccc(-c2ccc3ncnc(N)c3n2)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CN1CC=C(c2ccc(OC(F)(F)F)c(N)c2)CC1.[Pd]>>CN1CCC(c2ccc(OC(F)(F)F)c(N)c2)CC1",
        "output": "806"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)[P+](Cl)(N(C)C)N(C)C.CN1CCCC1=O.NCCCN(C(=O)c1cccs1)c1nc(-c2cc3ccccc3o2)cs1.O=C(O)CCN1CCCCC1.[O-][Cl+3]([O-])([O-])[O-]>>O=C(CCN1CCCCC1)NCCCN(C(=O)c1cccs1)c1nc(-c2cc3ccccc3o2)cs1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COC[C@H](C)N.C[Si](C)(C)CCOCn1cc(C(=O)O)c2nc(-c3n[nH]c4cc(Cl)cc(F)c34)cnc21.Cl.F[P-](F)(F)(F)(F)F.On1nnc2ccccc21>>COC[C@H](C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3n[nH]c4cc(Cl)cc(F)c34)nc12",
        "output": "737"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CO.Cn1c(Cc2ccccc2)ncc(-c2ccc(O)c(F)c2)c1=O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>Cn1c(Cc2ccccc2)ncc(-c2ccc(OS(=O)(=O)C(F)(F)F)c(F)c2)c1=O",
        "output": "843"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)Cc1coc(-c2cccs2)n1.[H-].[Li]>>OCCc1coc(-c2cccs2)n1",
        "output": "225"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CI.CN(C)C=O.COC(=O)c1ncccc1O.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ncccc1OC",
        "output": "661"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(C)=O.NCC(Nc1cccc([N+](=O)[O-])c1)C(F)(F)F.O>>CC(C)(C)OC(=O)NCC(Nc1cccc([N+](=O)[O-])c1)C(F)(F)F",
        "output": "631"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC1(c2cc(F)cc(OCc3ccc4c(c3)CCC(=O)N4C)c2)CCOCC1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>COC1(c2cc(F)cc(OCc3ccc4c(c3)CCC(=S)N4C)c2)CCOCC1",
        "output": "695"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(C(=O)NC2CC2)cc1-c1ccc(-c2nnc(CN)o2)cc1.ClCCl.O=S(=O)(Cl)Cc1ccccc1.c1ccncc1>>Cc1ccc(C(=O)NC2CC2)cc1-c1ccc(-c2nnc(CNS(=O)(=O)Cc3ccccc3)o2)cc1",
        "output": "493"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=C(c1ccc(OC(C)=O)cc1)c1ccc(OC(C)=O)cc1)c1ccc(/C=C/C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCC(=C(c1ccc(OC(C)=O)cc1)c1ccc(OC(C)=O)cc1)c1ccc(/C=C/C(=O)O)cc1",
        "output": "158"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)c1cc(-c2ccc(NC(=O)OC(C)(C)C)cn2)n(-c2cnccn2)n1.[Na+].[OH-]>>CC(C)(C)OC(=O)Nc1ccc(-c2cc(C(=O)O)nn2-c2cnccn2)nc1",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1coc(CN2C(=O)C3(COc4cc5c(cc43)CCO5)c3ccccc32)n1.O.[Na+].[OH-]>>O=C(O)c1coc(CN2C(=O)C3(COc4cc5c(cc43)CCO5)c3ccccc32)n1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "N#Cc1c([N+](=O)[O-])cccc1[N+](=O)[O-].OCCCCCCO>>N#Cc1c(OCCCCCCO)cccc1[N+](=O)[O-]",
        "output": "499"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1cc[n+]([O-])cc1.CN(C)C(=O)Cl.C[Si](C)(C)C#N.ClCCl.O=C([O-])[O-].[K+].[K+]>>CC(C)c1ccnc(C#N)c1",
        "output": "720"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)OC(=O)N1CCC(O)CC1.CCOC(C)=O.CN(C)C=O.Clc1ccc(Br)cn1.[H-].[Na+]>>CC(C)OC(=O)N1CCC(Oc2ccc(Br)cn2)CC1",
        "output": "433"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.ClCCl.Nc1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1.O=C(Cl)C(=O)Cl.O=C(O)c1ccccc1Cc1ccccc1>>O=C(Nc1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1)c1ccccc1Cc1ccccc1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.COC(=O)c1ccc(C2CCN(c3ccc(CN4CCOCC4)cc3)CC2)cc1.Cl.[Na+].[OH-]>>O=C(O)c1ccc(C2CCN(c3ccc(CN4CCOCC4)cc3)CC2)cc1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.NC12CC3CC(CC(C3)C1)C2.Nc1nc(Cl)cc(-c2cccc(Cl)c2Cl)n1>>Nc1nc(NC23CC4CC(CC(C4)C2)C3)cc(-c2cccc(Cl)c2Cl)n1",
        "output": "110"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CI.CN(C)C=O.Cn1cccc1-c1nsc2ccc(-n3c(=O)cc(C(F)(F)F)[nH]c3=O)cc12.O=C([O-])[O-].[K+].[K+]>>Cn1cccc1-c1nsc2ccc(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)cc12",
        "output": "570"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.CCc1cnc(-c2cnc(Cl)c(Cl)c2SC)o1.COC(=O)C1CCNCC1>>CCc1cnc(-c2cnc(N3CCC(C(=O)OC)CC3)c(Cl)c2SC)o1",
        "output": "220"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1nc(Cl)nc2c1ncn2Cc1ccccc1.OCCCO.[Na]>>Nc1nc(OCCCO)nc2c1ncn2Cc1ccccc1",
        "output": "37"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C[C@@H](N)C(F)(F)F.Nc1cnc(-c2ccc(-c3ccccc3C(=O)O)cc2F)cn1>>C[C@@H](NC(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1)C(F)(F)F",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)C[C@@H]1CC(=O)O.CC(C)=O.CI.O=C([O-])[O-].[K+].[K+]>>COC(=O)C[C@H]1CN(C(=O)OCc2ccccc2)CCN1C(=O)OC(C)(C)C",
        "output": "415"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)[C@H]1CC[C@@H](Oc2ccc(C(=O)Nc3nnc(COC4CCCC4)s3)cc2)CC1.Cl.O.O.[Li+].[OH-]>>O=C(Nc1nnc(COC2CCCC2)s1)c1ccc(O[C@@H]2CC[C@H](C(=O)O)CC2)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COCc1ccccc1N1CCN(C(=O)[C@H]2COc3ccccc3O2)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>COCc1ccccc1N1CCN(C[C@H]2COc3ccccc3O2)CC1",
        "output": "363"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1.O=C1CCC(O)(c2ccc(O)cc2)CC1>>O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(O)(c3ccc(O)cc3)CC2)C1",
        "output": "187"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)[O-].CC(=O)[O-].CN(C)C.ClCCl.N#Cc1cccc(Br)c1.O=C1CC(c2ccc(OCc3ccccc3)c(OC3CCCC3)c2)CN1.Oc1ccccc1.[Cu+2]>>N#Cc1cccc(N2CC(c3ccc(OCc4ccccc4)c(OC4CCCC4)c3)CC2=O)c1",
        "output": "809"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.O.O=C1Cc2cccc3cccc1c23.[BH4-].[Na+]>>OC1Cc2cccc3cccc1c23",
        "output": "24"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CI.CN(C)C=O.Cc1c(C(=O)O)cc(Cl)cc1[N+](=O)[O-].O=C([O-])[O-].[Na+].[Na+]>>COC(=O)c1cc(Cl)cc([N+](=O)[O-])c1C",
        "output": "415"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCCCBr.CC(C)=O.Nc1ccc(O)cc1[N+](=O)[O-].O=C([O-])[O-].[Cs+].[Cs+]>>Nc1ccc(OCCCBr)cc1[N+](=O)[O-]",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.C[O-].Cc1nc2ccc(Cl)nn2c1S(N)(=O)=O.[Na+]>>COc1ccc2nc(C)c(S(N)(=O)=O)n2n1",
        "output": "407"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)CCC1(OC)C=CC(OC)O1.CO.Cc1ccccc1.O.O=S(=O)([O-])[O-].[H-].[Na+].[Na+]>>COC1C=CC(CCC=O)(OC)O1",
        "output": "260"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)CC(C)(C)c1ccc(OCc2ccccc2)c(OCC2(C)CCC(CO)O2)c1.CCO.[Pd]>>CC(C)(C)CC(C)(C)c1ccc(O)c(OCC2(C)CCC(CO)O2)c1",
        "output": "23"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCCC1=O.Cc1cc(O)cc(=O)[nH]1.Cl.Fc1cc(Cl)cc(Br)c1.O.O=C([O-])[O-].[K+].[K+]>>Cc1cc(Oc2cc(Cl)cc(Br)c2)cc(=O)[nH]1",
        "output": "564"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)C(=O)Cl.CC(C)OC(C)C.CCN(CC)CC.Cl.O.OCC(F)(F)Br>>CC(C)(C)C(=O)OCC(F)(F)Br",
        "output": "126"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCOCC.CC[SiH](CC)CC.COc1ccc(C(=O)c2cc(Br)ccc2F)cc1.ClCCl.FB(F)F.O.[K+].[OH-]>>COc1ccc(Cc2cc(Br)ccc2F)cc1",
        "output": "181"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1ccn2c(-c3ccc4cccc(OCc5ccccc5)c4n3)cnc2c1.CO.O=C[O-].[NH4+].[OH-].[OH-].[Pd+2]>>CCc1ccn2c(-c3ccc4cccc(O)c4n3)cnc2c1",
        "output": "264"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1ccc(F)c(-c2c(F)ccc(NC(C)=O)c2F)n1.[Li+].[OH-]>>CC(=O)Nc1ccc(F)c(-c2nc(C(=O)O)ccc2F)c1F",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.N#CCCO.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCC#N",
        "output": "193"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCOC(C)=O.FC(F)(F)c1ccc(CNc2ncnc3c2CNCC3)cn1.N#Cc1cc(Br)ccc1F>>N#Cc1cc(Br)ccc1N1CCc2ncnc(NCc3ccc(C(F)(F)F)nc3)c2C1",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrBr.C1COCCO1.CC(=O)c1cccc2ccccc12>>O=C(CBr)c1cccc2ccccc12",
        "output": "173"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCCN(CC)C(C)CCCc1ccc([N+](=O)[O-])cc1.CCO.[H][H].[Pd]>>CCCCCCCN(CC)C(C)CCCc1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccccc1.CC#N.CCOC(C)=O.Cc1ccc(O)cn1.O.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(OCc2ccccc2)cn1",
        "output": "623"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.N#Cc1cnn2cccc2c1NC1CCCC1.OO.[NH4+].[OH-]>>NC(=O)c1cnn2cccc2c1NC1CCCC1",
        "output": "677"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.Cc1nc(N)ccc1C#N.O=C1CCC(=O)N1Cl>>Cc1nc(N)c(Cl)cc1C#N",
        "output": "743"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@@H]1CN2C(=N1)C(N1CC(N(C)C(=O)OC(C)(C)C)C1)=Nc1ncc(Br)cc12.ClCCl.O=C(O)C(F)(F)F>>CNC1CN(C2=Nc3ncc(Br)cc3N3C[C@@H](C)N=C23)C1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN.Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1nccc(-c2ccc(Cl)nc2)n1.O>>CNc1ccc(-c2ccnc(Nc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)n2)cn1",
        "output": "70"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCC.O=C(N1CCC(O)CC1)C12CC(c3ccccc31)c1ccccc12.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OC1CCN(CC23CC(c4ccccc42)c2ccccc23)CC1",
        "output": "112"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nc1nc(-c2sccc2Cl)cs1.O=S(=O)(Cl)c1c(Cl)cc(Cl)cc1Cl>>O=S(=O)(Nc1nc(-c2sccc2Cl)cs1)c1c(Cl)cc(Cl)cc1Cl",
        "output": "637"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC[C@H]1CN(C(=O)OC(C)(C)C)CCN1c1ccc([N+](=O)[O-])nc1.CO.[Pd]>>CC[C@H]1CN(C(=O)OC(C)(C)C)CCN1c1ccc(N)nc1",
        "output": "457"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.CN(C)C=O.O.O=C([O-])[O-].Oc1cccnc1Br.[K+].[K+]>>Brc1ncccc1OCc1ccccc1",
        "output": "623"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC[C@@H]1C(=O)N(C)c2cnc(-n3ccc(C(=O)O)n3)nc2N1C1CCCC1.CN.Cl>>CC[C@@H]1C(=O)N(C)c2cnc(-n3ccc(C(=O)NC)n3)nc2N1C1CCCC1",
        "output": "816"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cc1cc(N)c2c(c1)CC(CO)O2.O=C1CCC(=O)N1Br>>Cc1cc(N)c2c(c1Br)CC(CO)O2",
        "output": "4"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCCC1=O.C[C@@](O)(C(=O)Nc1ccc(S(=O)(=O)c2ccccc2F)cc1Cl)C(F)(F)F.NCCO.[Cl-].[NH4+]>>C[C@@](O)(C(=O)Nc1ccc(S(=O)(=O)c2ccccc2NCCO)cc1Cl)C(F)(F)F",
        "output": "572"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.Nc1ccccc1N.O.O=C([O-])[O-].O=C1CCN([C@@H]2Cc3ccc(F)c4cccc2c34)CC1.[K+].[K+].[Na+]>>Nc1ccccc1NC1CCN([C@@H]2Cc3ccc(F)c4cccc2c34)CC1",
        "output": "469"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "B.C1CCOC1.C1CCOC1.CC(C)(C#N)Cc1cccc(Br)c1>>CC(C)(CN)Cc1cccc(Br)c1",
        "output": "246"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CSc1ccc(Br)cn1.[K+]>>CSc1ccc(B2OC(C)(C)C(C)(C)O2)cn1",
        "output": "943"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(CC=O)C(=O)OC(C)(C)C.CN(CC=O)C(=O)OC(C)(C)C.ClC(Cl)Cl.N[C@H]1CCCN(C(=O)OCc2ccccc2)C1.O.[Na+]>>CN(CCN[C@H]1CCCN(C(=O)OCc2ccccc2)C1)C(=O)OC(C)(C)C",
        "output": "426"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)n1ncc2cccc([N+](=O)[O-])c21.CCOC(C)=O.[Pd]>>CC(C)(C)OC(=O)n1ncc2cccc(N)c21",
        "output": "269"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.N[C@@H](CO)c1ccc(F)cc1.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)nc1Cl.[K+].[K+]>>O=[N+]([O-])c1ccc(Cl)nc1N[C@@H](CO)c1ccc(F)cc1",
        "output": "612"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.Nc1cc(Br)cc([N+](=O)[O-])c1>>CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1",
        "output": "6"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=CBr)c1ccc(Cl)cc1.CN(C)C=O.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3.O=C(O)[C@@H]1CCCN1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>C/C(=C\\n1c2c(c3cc(C)ccc31)CN(C)CC2)c1ccc(Cl)cc1",
        "output": "987"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1cccc(-c2n[nH]c3c2Cc2sccc2-3)c1.C1CCOC1.C[Si](C)(C)CCOCCl.[H-].[Na+]>>C[Si](C)(C)CCOCn1nc(-c2cccc(Br)c2)c2c1-c1ccsc1C2",
        "output": "910"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1cccc(Cc2c(-c3ccccc3)nn3cc(C#N)ccc23)n1.Cl.[K+].[OH-]>>N#Cc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN.Nc1nnc(-c2ccnc(Cl)c2)s1.O>>CNc1cc(-c2nnc(N)s2)ccn1",
        "output": "70"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.Cc1ccc(S(=O)(=O)OCCCNc2ccc(C#N)cc2)cc1.ClCCl.O.O=C([O-])[O-].[K+].[K+].c1ccc(CN2CC3CCC(C2)N3)cc1>>N#Cc1ccc(NCCCN2C3CCC2CN(Cc2ccccc2)C3)cc1",
        "output": "429"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(C)=O.C[Si](C)(C)CCOCn1ccc2c1ncc1c(=O)[nH]c(=O)n([C@@H]3CC[C@@H](CO)CC3)c12.Cc1ccccc1.O=C(O)c1ccccc1I(=O)=O.O=C([O-])O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>C[Si](C)(C)CCOCn1ccc2c1ncc1c(=O)[nH]c(=O)n([C@@H]3CC[C@@H](C=O)CC3)c12",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)n1nc(-c2ccc(O)cc2)c(C#N)c1N.CCOC(=O)c1nc(N2CCc3cccc(C(=O)N(COCC[Si](C)(C)C)c4nc5ccccc5s4)c3C2)sc1-c1ccc(CO)cc1.O=C(/N=N/C(=O)OCc1ccccc1)OCc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1nc(N2CCc3cccc(C(=O)N(COCC[Si](C)(C)C)c4nc5ccccc5s4)c3C2)sc1-c1ccc(COc2ccc(-c3nn(C(=O)OC(C)(C)C)c(N)c3C#N)cc2)cc1",
        "output": "550"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.O=C(CCBr)c1ccccc1.OCCO.c1ccccc1>>BrCCC1(c2ccccc2)OCCO1",
        "output": "93"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.COC(=O)[C@@H]1C[C@@H](OS(C)(=O)=O)CN1C(=O)OCc1ccc(OC)cc1.O=S(=O)(O)O.[BH4-].[Na+]>>COc1ccc(COC(=O)N2C[C@H](OS(C)(=O)=O)C[C@H]2CO)cc1",
        "output": "430"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)Cl.O=C(O)C1CN(C(c2ccccc2)c2ccccc2)C1>>OCC1CN(C(c2ccccc2)c2ccccc2)C1",
        "output": "231"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCCSC)CC2)c2ncnn12.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n([C@@H]2CC[C@@H](OCCSC)CC2)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H]2[C@H](C1)c1cc(Br)cc3c1N2CC3.COc1ccc(B(O)O)c(OC)c1>>COc1ccc(-c2cc3c4c(c2)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@H]2N4CC3)c(OC)c1",
        "output": "837"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1.CSCC[C@H](N)C(=O)O.Cl.[Li+].[OH-]>>CC(C)C[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(=O)Cl.ClC(Cl)Cl.O=C([O-])O.[Na+].c1ccc(N2CC3(CCNCC3)c3ccccc32)cc1>>CCC(=O)N1CCC2(CC1)CN(c1ccccc1)c1ccccc12",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.Cc1ccc(-c2cc3c4cc(C)ccc4[nH]c3n(C)c2=O)c(C)c1.[H-].[Na+]>>Cc1ccc(-c2cc3c4cc(C)ccc4n(C)c3n(C)c2=O)c(C)c1",
        "output": "570"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.Cl.Fc1ncccc1Br.O.O=C([O-])[O-].[Cs+].[Cs+].c1ccc2nc(C3CNC3)ccc2c1>>Brc1cccnc1N1CC(c2ccc3ccccc3n2)C1",
        "output": "756"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)Cn1ccc2ccc(OCc3c(Br)c(-c4ccc(C(F)(F)F)cc4)nn3C)cc21.[Li+].[OH-]>>Cn1nc(-c2ccc(C(F)(F)F)cc2)c(Br)c1COc1ccc2ccn(CC(=O)O)c2c1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.NC12CC3CC(CC(C3)C1O)C2>>CC(C)(C)OC(=O)NC12CC3CC(CC(C3)C1O)C2",
        "output": "631"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1c2n(c3c(Br)cc(F)cc13)CCNC2=O.OB(O)c1ccc(F)nc1>>Cc1c2n(c3c(-c4ccc(F)nc4)cc(F)cc13)CCNC2=O",
        "output": "883"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)OC(C)C.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CCc1nnc(C(C)(N)CO)o1.CN(C)C=O.Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)O.Cl.O.O=C(O)C(F)(F)F.On1nnc2ccccc21>>CCc1nnc(C(C)(CO)NC(=O)c2c(C)nc3c(OCc4c(F)cccc4F)cccn23)o1",
        "output": "697"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)c1ccc(Cl)cc1Br.CO.Cl.[BH4-].[Na+]>>CC(O)c1ccc(Cl)cc1Br",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(CNC(=O)C2(CCCCBr)c3ccccc3-c3ccccc32)cc1.c1ccc2sc(N3CCNCC3)nc2c1>>COc1ccc(CNC(=O)C2(CCCCN3CCN(c4nc5ccccc5s4)CC3)c3ccccc3-c3ccccc32)cc1",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CCN(CC)CCN.Cc1[nH]c(C=O)c(C)c1C(=O)O.On1nnc2ccccc21>>CCN(CC)CCNC(=O)c1c(C)[nH]c(C=O)c1C",
        "output": "674"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCc1nnc2cc(C)c(-c3ccc(C#N)cc3)nn12.OO.[Na+].[OH-]>>CCc1nnc2cc(C)c(-c3ccc(C(N)=O)cc3)nn12",
        "output": "180"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc2c(Oc3cc(C)c(C)nc3-c3ccc(C)cn3)ccnc2cc1OCc1ccccc1.CS(=O)(=O)O.O=C(O)C(F)(F)F>>COc1cc2c(Oc3cc(C)c(C)nc3-c3ccc(C)cn3)ccnc2cc1O",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)CCCCCBr.CC(C)=O.CCCCNC(=O)[C@H](C)C[C@H](O)[C@H](Cc1cccc(O)c1)NC(=O)[C@H](C)NC(=O)OC(C)(C)C.CCOC(C)=O.O.[I-].[K+]>>CCCCNC(=O)[C@H](C)C[C@H](O)[C@H](Cc1cccc(OCCCCCC(=O)OC(C)(C)C)c1)NC(=O)[C@H](C)NC(=O)OC(C)(C)C",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNCC1.CCO.Cl.O=Cc1cccc(OCCCNC(=O)CS(=O)Cc2ccco2)c1.[BH4-].[Na+]>>O=C(CS(=O)Cc1ccco1)NCCCOc1cccc(CN2CCCCC2)c1",
        "output": "567"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCOc1cccc2c1CCNC2.CCN(CC)CC.Cl.O>>CCCOc1cccc2c1CCN(C(=O)OC(C)(C)C)C2",
        "output": "867"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)[C@@H](C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O)N(C)C(=O)OCc1ccccc1.CO.[H][H].[OH-].[OH-].[Pd+2]>>CN[C@H](C(=O)N(C)[C@@H](Cc1ccc(O)c(C(C)(C)C)c1)C(N)=O)C(C)C",
        "output": "568"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CC1.O=C(c1cc2nccc(Cl)c2s1)N1CC[C@@H](O)C1>>O=C(c1cc2nccc(Cl)c2s1)N1CC[C@@H](OCC2CC2)C1",
        "output": "95"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)S(=O)NC(CC(=O)O)c1ccc(F)c(Oc2ccccc2)c1F.CCN=C=NCCCN(C)C.CN(C)C=O.Nc1ccncc1.On1nnc2ccccc21>>CC(C)(C)S(=O)NC(CC(=O)Nc1ccncc1)c1ccc(F)c(Oc2ccccc2)c1F",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)CCC(C)(C)N1.CO.O=c1c2ccccc2cc(OCC(O)CCl)c2sccc12.O=c1c2ccccc2cc(OCC2CO2)c2sccc12>>CC1(C)CCC(C)(C)N1CC(O)COc1cc2ccccc2c(=O)c2ccsc12",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1c(-c2c(Cl)cncc2Cl)noc1C.[Na+].[OH-]>>Cc1onc(-c2c(Cl)cncc2Cl)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.COc1ccc(Sc2ccc(CN)cc2)cc1.Nc1ncccc1C(=O)O.O=C([O-])O.On1nnc2ccccc21.[Na+]>>COc1ccc(Sc2ccc(CNC(=O)c3cccnc3N)cc2)cc1",
        "output": "790"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.O.O=C(O)c1ccnc(Cl)c1.O=S(=O)(O)O>>CCOC(=O)c1ccnc(Cl)c1",
        "output": "33"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.COc1ccnc(CSc2nc3ccccc3[nH]2)c1C>>Cc1c(O)ccnc1CSc1nc2ccccc2[nH]1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.N.O.O=[N+]([O-])c1ccc(O)c(OC(F)(F)F)c1.[Cl-]>>Nc1ccc(O)c(OC(F)(F)F)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cc1ccc(Cl)c(S(C)(=O)=O)c1.CO.[Pd]>>CC(=O)Cc1cccc(S(C)(=O)=O)c1",
        "output": "253"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1cccc(-c2ocnc2C(=O)Nc2cnn(CCO)c2)c1.ClCCl>>Cc1cccc(-c2ocnc2C(=O)Nc2cnn(CCOS(C)(=O)=O)c2)c1",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CS(C)=O.Cc1ccc(-c2c(CNC(=O)OC(C)(C)C)c(CC(C)C)nc3ccc(C#N)cc23)cc1.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>Cc1ccc(-c2c(CNC(=O)OC(C)(C)C)c(CC(C)C)nc3ccc(-c4nn[nH]n4)cc23)cc1",
        "output": "390"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOCCCc1ccc(Oc2ccc3c(c2)C=C(C(=O)OC)CCS3(=O)=O)cc1.CO.[Na+].[OH-]>>CCOCCCc1ccc(Oc2ccc3c(c2)C=C(C(=O)O)CCS3(=O)=O)cc1",
        "output": "58"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](N)[C@H](c2ccc(F)c(Cl)c2)C1.Cc1ccc(S(=O)(=O)O)cc1.O=C(O)c1ccc(Cl)cc1>>CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)c2ccc(Cl)cc2)[C@H](c2ccc(F)c(Cl)c2)C1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.Cc1c(NC(=O)[C@@](C)(O)C(F)(F)F)ccc(I)c1Cl.O=C(O)c1ccc(S)cc1.O=[Cu-]>>Cc1c(NC(=O)[C@@](C)(O)C(F)(F)F)ccc(Sc2ccc(C(=O)O)cc2)c1Cl",
        "output": "565"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCCCC.CCOC(C)=O.CN(C)C=O.COC(=O)c1ccc(COCCO)cc1.c1c[nH]cn1>>COC(=O)c1ccc(COCCO[Si](C)(C)C(C)(C)C)cc1",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.Nc1cc(-c2ccncc2)c(-c2ccco2)nc1N.O=C(Cl)C1CC1>>Nc1nc(-c2ccco2)c(-c2ccncc2)cc1NC(=O)C1CC1",
        "output": "422"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.ClCCl.NCc1ccco1.O=C(O)c1ccc(OCC(=O)C23CC4CC(CC(C4)C2)C3)cc1>>O=C(NCc1ccco1)c1ccc(OCC(=O)C23CC4CC(CC(C4)C2)C3)cc1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CN1C(=O)[C@@H](N)CCC[C@H]1c1ccccc1.CN1CCOCC1.C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O.Cl.ClCCl>>C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@H]1CCC[C@@H](c2ccccc2)N(C)C1=O",
        "output": "133"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.COc1cccc(-n2nnn(C)c2=O)c1CBr.O.O=C([O-])[O-].Oc1cccc(O)c1.[K+].[K+]>>COc1cccc(-n2nnn(C)c2=O)c1COc1cccc(O)c1",
        "output": "127"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C[C@H](N)C(=O)C1(N)C(=O)N(CC(C)(C)C)c2ccccc2N(CC(C)(C)C)C1=O.Cl.O=C(O)Cc1cc(F)cc(F)c1>>C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)C1(N)C(=O)N(CC(C)(C)C)c2ccccc2N(CC(C)(C)C)C1=O",
        "output": "645"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCNC(=O)NC(C)(C)COc1cccc(N)c1C#N.NS(=O)(=O)Cl>>CCNC(=O)NC(C)(C)COc1cccc(NS(N)(=O)=O)c1C#N",
        "output": "395"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OCCNCC(O)c1ccc(Br)cc1F>>CC(C)(C)OC(=O)N(CCO)CC(O)c1ccc(Br)cc1F",
        "output": "694"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1cccc(OCc2ccccc2)c1.CC(C)(C)C(=O)CC(=O)C(C)(C)C.CN1CCCC1=O.COC(=O)CCc1ccc(O)cc1C.Cl[Cu].O.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)CCc1ccc(Oc2cccc(OCc3ccccc3)c2)cc1C",
        "output": "238"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(C(=O)N(C)C2CN(C(=O)C3CCNCC3)CC2c2ccc(Cl)cc2)cc1C(F)(F)F.O=CC1CC1>>COc1ccc(C(=O)N(C)C2CN(C(=O)C3CCN(CC4CC4)CC3)CC2c2ccc(Cl)cc2)cc1C(F)(F)F",
        "output": "484"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(CCc1ccccc1NS(=O)(=O)c1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CN[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1NS(=O)(=O)c1ccccc1",
        "output": "634"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)c1cnc2sc3ccccc3n12.Nc1nc2ccccc2s1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1cnc2sc3ccccc3n12",
        "output": "286"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.COc1ccc(B(O)O)cc1.Cc1cnc(Cl)c(C)n1.Cl[Pd]Cl.O.O=C([O-])[O-].[Na+].[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(-c2ncc(C)nc2C)cc1",
        "output": "875"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)[C@H](Cc1ccc(OCc2c(C)noc2C)cc1)Nc1nc(-c2ccccc2)cs1.Cl.O.O.[Li+].[OH-]>>Cc1noc(C)c1COc1ccc(C[C@H](Nc2nc(-c3ccccc3)cs2)C(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "B#B.CN(C)CCC(=O)c1ccccc1.CNCCC(Oc1ccc(C(F)(F)F)cc1)c1ccccc1.Cl>>CN(C)CCC(O)c1ccccc1",
        "output": "24"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cn(-c2ccc(CN3CCCC3)cc2)c2c(C#N)c(N3CCN(c4ccccn4)CC3)c(F)cc2c1=O.CO.Cl.[Na+].[OH-]>>N#Cc1c(N2CCN(c3ccccn3)CC2)c(F)cc2c(=O)c(C(=O)O)cn(-c3ccc(CN4CCCC4)cc3)c12",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(Cc1ncn2c1CCc1cc(C)ccc1-2)N1CC[C@H](NC(=O)OC(C)(C)C)C1.CO.[Na+].[OH-]>>Cc1ccc2c(c1)CCc1c(CC(C(=O)O)N3CC[C@H](NC(=O)OC(C)(C)C)C3)ncn1-2",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)C(=O)OCCOc1ccccc1.CC(C)O.CCCCCC.O.O=C(O)Cc1ccccc1>>CC(C)(C)C(=O)OCCOc1ccc(C(=O)Cc2ccccc2)cc1",
        "output": "435"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.NCCN1C(=O)C(NC(=O)c2cc3cc(Cl)ncc3[nH]2)Cc2ccccc21.O=C(O)C(F)(F)F>>CS(=O)(=O)NCCN1C(=O)C(NC(=O)c2cc3cc(Cl)ncc3[nH]2)Cc2ccccc21",
        "output": "493"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CN(C)C=O.ClCCl.Nc1cc(C(F)F)ccn1.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(Br)c(F)c1>>O=C(Nc1cc(C(F)F)ccn1)c1ccc(Br)c(F)c1",
        "output": "744"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Nc1nc2cc([N+](=O)[O-])ccc2[nH]1.CO.[Pd]>>CC(C)(C)OC(=O)Nc1nc2cc(N)ccc2[nH]1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)C1(S(=O)(=O)c2ccc(OCCC(C)C)cc2)CCN(Cc2ccccc2)CC1.CO.[Na+].[OH-]>>CC(C)CCOc1ccc(S(=O)(=O)C2(C(=O)O)CCN(Cc3ccccc3)CC2)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.Cl.NCc1ccc(Cl)cc1.O.O=C(O)CCNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.On1nnc2ccccc21>>O=C(CCNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCc1ccc(Cl)cc1",
        "output": "599"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCOCCOCCOCCOCCO1.CCCCCCCCBr.[K+].[OH-].c1ccc2[nH]ccc2c1.c1ccccc1>>CCCCCCCCn1ccc2ccccc21",
        "output": "470"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCN1.ClCCl.N#Cc1ccc(S(=O)(=O)Cl)c(Cl)c1>>N#Cc1ccc(S(=O)(=O)N2CCOCC2)c(Cl)c1",
        "output": "99"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.COc1cc2oc(=O)c3c(c2cc1O)CCC3.O=C([O-])O.OCCCCl.[K+]>>COc1cc2oc(=O)c3c(c2cc1OCCCO)CCC3",
        "output": "74"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1cc(OCC(C)C)c[n+]([O-])c1.O=P(Cl)(Cl)Cl>>COC(=O)c1cnc(Cl)c(OCC(C)C)c1",
        "output": "2"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)c1ncn2c1[C@@H]1CCCN1C(=O)c1c-2ccc(F)c1F.O.[Na+].[OH-]>>O=C(O)c1ncn2c1[C@@H]1CCCN1C(=O)c1c-2ccc(F)c1F",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=C(O)c1ccc(OCCCN2CCCCC2)cc1C(F)(F)F.O=S(Cl)Cl>>O=C(Cl)c1ccc(OCCCN2CCCCC2)cc1C(F)(F)F",
        "output": "3"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClCCl.Nc1ccc(Cl)cc1C(=O)c1ccccc1.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)Nc1ccc(Cl)cc1C(=O)c1ccccc1",
        "output": "473"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(CC)CO.ClCCl.O=C(Cl)c1ccc(CBr)cc1>>CCC(CC)COC(=O)c1ccc(CBr)cc1",
        "output": "51"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.COc1cc(C)c(C)cc1OC.Cc1ccccc1>>Cc1cc(O)c(O)cc1C",
        "output": "19"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.COC(=O)c1cc(C(F)(F)F)cnc1Br.[H-]>>OCc1cc(C(F)(F)F)cnc1Br",
        "output": "522"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.ClCCl.O=C(O)[C@@H]1CN(Cc2ccccc2)C[C@@H]1c1ccc(Cl)c(Cl)c1.O=C([O-])[O-].O=S(=O)(O)O.[Na+].[Na+]>>COC(=O)[C@@H]1CN(Cc2ccccc2)C[C@@H]1c1ccc(Cl)c(Cl)c1",
        "output": "195"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc(C2CCN(CCS(C)(=O)=O)CC2)c(C)cc1N.COc1ccc(-c2nc3ccccn3c2-c2ccnc(Cl)n2)cc1C(=O)Nc1c(F)cccc1F.C[O-].Cc1ccc(S(=O)(=O)O)cc1.ClCCl.OCC(F)(F)F.[Na+]>>COc1cc(C2CCN(CCS(C)(=O)=O)CC2)c(C)cc1Nc1nccc(-c2c(-c3ccc(OC)c(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1",
        "output": "808"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)c1cc(SC)cc(N)n1.[BH4-].[Li+]>>CSc1cc(N)nc(CO)c1",
        "output": "546"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)Cc1ccc([N+](=O)[O-])cc1>>O=C(Cl)Cc1ccc([N+](=O)[O-])cc1",
        "output": "56"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CI.CN(C)C=O.COC(=O)c1c(C)cc(-c2cccc(C(F)(F)F)c2)[nH]c1=O.COC(=O)c1c(C)cc(-c2cccc(C(F)(F)F)c2)nc1O.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)c1c(C)cc(-c2cccc(C(F)(F)F)c2)n(C)c1=O",
        "output": "191"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "B.C1CCOC1.C=CCc1c(Cl)nc2ccnn2c1N(C(=O)OC(C)(C)C)c1ccc(OCC)cc1.CSC.OO.[Na+].[OH-]>>CCOc1ccc(N(C(=O)OC(C)(C)C)c2c(CCCO)c(Cl)nc3ccnn23)cc1",
        "output": "465"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CCN(c1nc(Cl)ncc1[N+](=O)[O-])C1CCCC1C.CCOC(C)=O.[H][H].[Pd]>>CCOC(=O)CCN(c1nc(Cl)ncc1N)C1CCCC1C",
        "output": "660"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C(=O)Cl.CCN(CC)CC.ClCCl.O=[N+]([O-])c1ccc(N2CCNCC2)c(Cl)c1>>CC(C)C(=O)N1CCN(c2ccc([N+](=O)[O-])cc2Cl)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)c1cc(B2OC(C)(C)C(C)(C)O2)ccc1O.Cc1c(C(=O)NC2CCOCC2)cc(Br)n1CC1CCCCC1.Cl[Pd]Cl.O.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1c(C(=O)NC2CCOCC2)cc(-c2ccc(O)c(C(C)(C)C)c2)n1CC1CCCCC1",
        "output": "939"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)c1ccccc1SC1CN(C(=O)c2ccccc2)C1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>CC(C)(C)c1ccccc1S(=O)C1CN(C(=O)c2ccccc2)C1",
        "output": "500"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(CC(=O)O)cc1.CCOC(Cc1ccc(O)c(C)c1)C(=O)OCc1ccccc1.CCOC(Cc1ccc(OC(=O)Cc2nc(-c3ccccc3)oc2C)c(Cc2ccccc2)c1)C(=O)OCc1ccccc1>>CCOC(Cc1ccc(OC(=O)Cc2ccc(NC(=O)OC(C)(C)C)cc2)c(C)c1)C(=O)OCc1ccccc1",
        "output": "108"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(CO)COCc1ccccc1.CCOC(C)=O.ClCCl>>CC(C=O)COCc1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)CCO.COc1cc2c(Oc3ccc4[nH]ccc4c3)ncnc2cc1O>>COc1cc2c(Oc3ccc4[nH]ccc4c3)ncnc2cc1OCCN(C)C",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCCCCNC(=O)N(C)c1cccc(-c2ccc(CC(OCC)C(=O)OCC)cn2)c1.[Li+].[OH-]>>CCCCCCCNC(=O)N(C)c1cccc(-c2ccc(CC(OCC)C(=O)O)cn2)c1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COC(=O)Cc1ccc([N+](=O)[O-])c(O)c1.[Pd]>>COC(=O)Cc1ccc(N)c(O)c1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.N#Cc1ccc(-n2cc3cc(F)cc(C(N)=O)c3n2)cc1.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>NC(=O)c1cc(F)cc2cn(-c3ccc(-c4nnn[nH]4)cc3)nc12",
        "output": "390"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)[C@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)NCC(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(C)C.ClCCl>>COC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(C)C)C(C)C)C(C)C",
        "output": "133"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.Cc1cc(I)ccc1O.c1c[nH]cn1>>Cc1cc(I)ccc1O[Si](C)(C)C(C)(C)C",
        "output": "746"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)OC(=O)/N=N/C(=O)OC(C)C.Cc1ccccc1.Cc1oc(C(C)(C)C)nc1CCO.O=Cc1ccc(O)c2ccccc12.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1oc(C(C)(C)C)nc1CCOc1ccc(C=O)c2ccccc12",
        "output": "478"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CNCCN(C)C.COc1ccc(CN(Cc2ccc(OC)cc2)c2ncc(-c3nc(N4CCOCC4)nc4c3CCN4c3ccc(C(=O)O)cc3)cn2)cc1>>COc1ccc(CN(Cc2ccc(OC)cc2)c2ncc(-c3nc(N4CCOCC4)nc4c3CCN4c3ccc(C(=O)N(C)CCN(C)C)cc3)cn2)cc1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.COC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N.O=C(CNC(=O)OCc1ccccc1)N[C@@H](Cc1ccccc1)C(=O)O.O=C(n1ccnc1)n1ccnc1>>COC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)OCc1ccccc1",
        "output": "133"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.O=C(O)c1ccc2cccnc2c1O.O=S(Cl)Cl>>O=C(Cl)c1ccc2cccnc2c1O",
        "output": "3"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COCCn1nc2c(N)nc3ccccc3c2c1CC(C)(C)N.Cl.O=C(Cl)c1ccncc1>>COCCn1nc2c(N)nc3ccccc3c2c1CC(C)(C)NC(=O)c1ccncc1",
        "output": "271"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCc1cc(-c2ccc(C(=O)O)cn2)c(C)[nH]c1=O.OC1CCNC1>>CCc1cc(-c2ccc(C(=O)N3CCC(O)C3)cn2)c(C)[nH]c1=O",
        "output": "256"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOc1ccc(C=CC(=O)O)cc1.[Pd]>>CCOc1ccc(CCC(=O)O)cc1",
        "output": "344"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.CS(=O)(=O)c1ccc(C(Cc2ccc(F)cc2)C(=O)O)cc1.CSc1cnc(N)cn1.Cl.ClCCl>>CSc1cnc(NC(=O)C(Cc2ccc(F)cc2)c2ccc(S(C)(=O)=O)cc2)cn1",
        "output": "692"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.C[C@@H](CO)NC(=O)OC(C)(C)C.ClC(Cl)Cl.O>>C[C@@H](COS(C)(=O)=O)NC(=O)OC(C)(C)C",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Clc1ccc2cc[nH]c2c1.O.[Na+].[OH-]>>O=Cc1c[nH]c2cc(Cl)ccc12",
        "output": "266"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)O)c[nH]c23)c1.CCN(CC)CC.CCN=C=NCCCN(C)C.C[C@H](O)C(=O)N1CCC(N)CC1.Cl.Cl.ClCCl.On1nnc2ccccc21>>CC(=O)c1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)NC4CCN(C(=O)[C@H](C)O)CC4)c[nH]c23)c1",
        "output": "737"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccccc1.CC#N.CCOC(=O)C(O)(CC)CNC1CCCC1.CCOC(C)=O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C(O)(CC)CN(Cc1ccccc1)C1CCCC1",
        "output": "248"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.OCc1ccc(Cl)cc1.[Na+]>>COc1cc2nccc(Oc3cc(C)c(NC(=O)OCc4ccc(Cl)cc4)cc3C)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(C)=O.ClCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1.O.O=C1c2ccccc2C(=O)N1CCCOc1ccc(O)cc1.[Na+].[OH-]>>O=C1c2ccccc2C(=O)N1CCCOc1ccc(OCCN2CCN(CCCN3c4ccccc4Sc4ccc(Cl)cc43)CC2)cc1",
        "output": "74"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C(=O)O)C1CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1ccc(C(=O)Nc2cc(F)cc(CN3CCN[C@@H](C)C3)c2C)cn1.F[P-](F)(F)(F)(F)F.O>>Cc1ccc(C(=O)Nc2cc(F)cc(CN3CCN(C(=O)C(C)C4CC4)[C@@H](C)C3)c2C)cn1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.O=C1CCN(c2ccc(CN3CCOCC3)cc2)CC1>>c1cc(N2CCC(N3CCOCC3)CC2)ccc1CN1CCOCC1",
        "output": "187"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)[C@@H]1O[C@H]1C(=O)OCC.[K+].[OH-]>>CCOC(=O)[C@@H]1O[C@H]1C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC(=O)O.Cl.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3OCC4)CC2)CC1>>CCCC(=O)N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3OCC4)CC2)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.COC(=O)c1cc(Cl)ccc1NC(=O)[C@@H]1CCCN1.Cl.Cl.O.O=C(O)Cc1cccc(-c2ccoc2)c1.On1nnc2ccccc21>>COC(=O)c1cc(Cl)ccc1NC(=O)[C@@H]1CCCN1C(=O)Cc1cccc(-c2ccoc2)c1",
        "output": "297"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=C(Nc1cccc2ccccc12)c1ccccc1[N+](=O)[O-].[Pd]>>Nc1ccccc1C(=O)Nc1cccc2ccccc12",
        "output": "486"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cl[Ni]Cl.O=[N+]([O-])c1cc(OCc2ccccc2)c(C(F)(F)F)cc1F.[BH4-].[Na+]>>Nc1cc(OCc2ccccc2)c(C(F)(F)F)cc1F",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.COCCl.COc1cc(C(=O)Cn2c(-c3nonc3N)nc3ccccc32)ccc1O>>COCOc1ccc(C(=O)Cn2c(-c3nonc3N)nc3ccccc32)cc1OC",
        "output": "375"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)Cl)cc1.Nc1cc(F)c(F)cc1C(=O)c1ccncc1>>CC(C)(C)c1ccc(S(=O)(=O)Nc2cc(F)c(F)cc2C(=O)c2ccncc2)cc1",
        "output": "68"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cl.ClC(Cl)Cl.O.O=C1CCNCC1.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(=O)CC1",
        "output": "694"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCN(CCN)CCCC.O=C(O)c1ccc(Cl)cc1Nc1ccnc2cc(Cl)ccc12>>CCCCN(CCCC)CCNC(=O)c1ccc(Cl)cc1Nc1ccnc2cc(Cl)ccc12",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)c1ccc(N2C[C@@H](CN=[N+]=[N-])OC2=O)cc1F.O=Cc1cn(CC(=O)NCc2ccccc2)c2ccccc12.[BH3-]C#N.[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)c1ccc(N2C[C@H](CN)OC2=O)cc1F",
        "output": "89"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.COC(OC)C(C)Nc1ccc2c(c1)Sc1cccc(-c3cc(N4CCOCC4)cc(=O)[nH]3)c1S2.F[B-](F)(F)F.O.[Cl-].[Li+].[Na+]>>CC(C=O)Nc1ccc2c(c1)Sc1cccc(-c3cc(N4CCOCC4)cc(=O)[nH]3)c1S2",
        "output": "234"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCOC(=O)c1c(C)nc2c(OCc3ccccc3)cccn12.Cl.[Na+].[OH-]>>Cc1nc2c(OCc3ccccc3)cccn2c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.O=C1CCC2(CC1)CC(=O)c1cc(Br)ccc1O2.[BH4-].[Na+]>>O=C1CC2(CCC(O)CC2)Oc2ccc(Br)cc21",
        "output": "91"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CS(C)=O.Cc1ccc(B(O)O)cc1.Cc1ccc(C)cc1.N#Cc1ccccc1Cl.O.O.O=S(=O)([O-])c1cccc(P(c2cccc(S(=O)(=O)[O-])c2)c2cccc(S(=O)(=O)[O-])c2)c1.OCCOCCO.[F-].[K+].[Na+].[Na+].[Na+].[Pd+2]>>Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "892"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1cc(-c2cnn(C)c2)c2ccc(C)c(F)c2n1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)c1cc(-c2cnn(C)c2)c2ccc(CBr)c(F)c2n1",
        "output": "29"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1sc2nc(Cl)nc(Cl)c2c1Cl.NCCc1ccc2c(c1)OCO2>>Cc1sc2nc(Cl)nc(NCCc3ccc4c(c3)OCO4)c2c1Cl",
        "output": "723"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)C(C)(C)c1ccccc1.O.[K+].[OH-]>>CC(C)(C(=O)O)c1ccccc1",
        "output": "203"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CBr.CN(C)C=O.Cc1ccc(C2CCCN(C(=O)OCc3ccccc3)C2)cc1O.O.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)COc1cc(C2CCCN(C(=O)OCc3ccccc3)C2)ccc1C",
        "output": "123"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCOC(CN)C1.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Nc1ncnn2c(C(=O)O)ccc12.O.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CC(C)(C)OC(=O)N1CCOC(CNC(=O)c2ccc3c(N)ncnn23)C1",
        "output": "816"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)Cc1ccc2c(C(C)=O)cn(CC(=O)N3C[C@H](F)C[C@H]3C(=O)NCc3cccc(Cl)c3F)c2c1.O.[Na+].[OH-]>>CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cc(CC(=O)O)ccc12",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.CCOC(C)=O.OCCN1CCOCC1.Oc1ccc(Br)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Brc1ccc(OCCN2CCOCC2)cc1",
        "output": "550"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=[N+]([O-])c1cccc(-c2nc3n(n2)CCc2ccccc2-3)c1.[Pd]>>Nc1cccc(-c2nc3n(n2)CCc2ccccc2-3)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)CCC(C)(C)c2c1cc(C(=O)O)c(O)c2Br.CC1(C)CCC(C)(C)c2cc(C(=O)O)c(O)cc21.COCCl>>COCOc1c(C(=O)O)cc2c(c1Br)C(C)(C)CCC2(C)C",
        "output": "375"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCOC(=O)c1cn(-c2cc(C(C)(C)C)cc(C3(C)CC3)c2)c(C(O)C2CCCCC2)c1C.ClCCl>>CCOC(=O)c1cn(-c2cc(C(C)(C)C)cc(C3(C)CC3)c2)c(C(=O)C2CCCCC2)c1C",
        "output": "456"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCCCCCCCCCCCCCCC(=O)OC.C[O-].Cc1ccccc1.OCCN1CCOCC1.[Na+]>>CCCCCCCCCCCCCCCCCCCCCC(=O)OCCN1CCOCC1",
        "output": "289"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCI.CCOC(C)=O.CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(CN2CCNCC2)cc(OC(F)(F)F)c1.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCN1CCN(Cc2cc(OC(F)(F)F)cc(C(=O)NCc3cc(Cl)ccc3S(=O)(=O)CC)c2)CC1",
        "output": "184"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)CNn1c(=O)c(C2=NS(=O)(=O)c3cc(O)ccc3N2)c(O)c2ccccc21.COC(=O)c1cc(Cl)nc(Cl)c1.O=C([O-])[O-].O=[Cu].[K+].[K+].c1ccncc1>>COC(=O)c1cc(Cl)nc(Oc2ccc3c(c2)S(=O)(=O)N=C(c2c(O)c4ccccc4n(NCC(C)C)c2=O)N3)c1",
        "output": "516"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CCBr.CN(C)C=O.O.O=C([O-])[O-].Oc1ccc(-c2nc3c(NC4CCCC4)cccn3c2-c2ccnc(NC3CCCC3)n2)cc1.[Cs+].[Cs+]>>C=CCOc1ccc(-c2nc3c(NC4CCCC4)cccn3c2-c2ccnc(NC3CCCC3)n2)cc1",
        "output": "77"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.N#Cc1cccc2c1nc(-c1c(F)cccc1F)n2Cc1c(F)cccc1F.O=C([O-])[O-].OO.[Na+].[Na+]>>NC(=O)c1cccc2c1nc(-c1c(F)cccc1F)n2Cc1c(F)cccc1F",
        "output": "677"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cn1nccc1-c1nc2ccccc2[nH]1.O=c1cc(CBr)c2ccc(F)c(F)c2[nH]1>>Cn1nccc1-c1nc2ccccc2n1Cc1cc(=O)[nH]c2c(F)c(F)ccc12",
        "output": "658"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCOC(=O)CC1CCN(c2ncc(S(C)(=O)=O)cc2N)CC1.O=C(Cl)c1cccc(Cl)c1>>CCOC(=O)CC1CCN(c2ncc(S(C)(=O)=O)cc2NC(=O)c2cccc(Cl)c2)CC1",
        "output": "501"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cc(N)ccc1Br.O=C1C=CC(=O)O1>>Cc1cc(N2C(=O)C=CC2=O)ccc1Br",
        "output": "410"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCC#Cc1cc(Cl)c(Nc2ncnc3cc(OCCCCl)cc(OC(C)C)c23)c2c1OCO2.COCCO.ClCCl.O=CN1CCNCC1.[I-].[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COCC#Cc1cc(Cl)c(Nc2ncnc3cc(OCCCN4CCN(C=O)CC4)cc(OC(C)C)c23)c2c1OCO2",
        "output": "138"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cn1c(CO[Si](C)(C)C(C)(C)C)cc2c3c(ccc21)C(O)CCC=C3.[Pd]>>Cn1c(CO[Si](C)(C)C(C)(C)C)cc2c3c(ccc21)C(O)CCCC3",
        "output": "362"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Cc1ccccc1.N.O.O=C(O)Cc1ccc(CBr)cc1>>NC(=O)Cc1ccc(CBr)cc1",
        "output": "313"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.FC(F)(F)c1ccnc(Cl)c1.O.Oc1ccc(I)cc1.[H-].[Na+]>>FC(F)(F)c1ccnc(Oc2ccc(I)cc2)c1",
        "output": "516"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1cnc(Oc2cccc(C=C3CCNCC3)c2)nc1.CC#N.CCN(C(C)C)C(C)C.Nc1cccnc1.O=C(Nc1cccnc1)Oc1ccccc1.O=C(O)C(F)(F)F>>O=C(Nc1cccnc1)N1CCC(=Cc2cccc(Oc3ncc(Br)cn3)c2)CC1",
        "output": "525"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1[nH]c(C)c(Br)c1C#N.CO.O.[Li+].[OH-]>>Cc1[nH]c(C(=O)O)c(C#N)c1Br",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.c1ccc2c(c1)cc1n2CCNC1>>CC(C)(C)OC(=O)N1CCn2c(cc3ccccc32)C1",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.Cn1c(CCc2ccc(F)cc2)cc(=O)n1-c1ccc(F)cc1.O=C1CCC(=O)N1Br.[Al]>>Cn1c(CCc2ccc(F)cc2)c(Br)c(=O)n1-c1ccc(F)cc1",
        "output": "620"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CS(=O)(=O)c1ccc(C(=O)O)cc1.ClCCl.Nc1ccccc1Cl.O=S(Cl)Cl>>CS(=O)(=O)c1ccc(C(=O)Nc2ccccc2Cl)cc1",
        "output": "50"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)[O-].Nc1ccc(Br)cc1.O=[N+]([O-])c1cc(S(=O)(=O)Cl)ccc1Cl.[Na+]>>O=[N+]([O-])c1cc(S(=O)(=O)Nc2ccc(Br)cc2)ccc1Cl",
        "output": "68"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)N.CCc1nc(Cl)c([N+](=O)[O-])c(Cl)n1>>CCc1nc(Cl)c([N+](=O)[O-])c(NC(C)C)n1",
        "output": "166"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O.OCC1CC1>>C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)OCC1CC1",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCCOc2ccccc2CCN)cc1.CS(=O)(=O)Cl.ClCCl>>COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCCOc2ccccc2CCNS(C)(=O)=O)cc1",
        "output": "493"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(C)c4)c3)c3cc(-c4ccc(N5CCN(C[C@H](C)O)CC5)cc4)cnc32)cc1.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4ccc(C5CCNCC5)cc4)cnc32)cc1.Cl.O.[Li+].[OH-]>>Cc1cccc(Cn2cc(-c3c[nH]c4ncc(-c5ccc(N6CCN(C[C@H](C)O)CC6)cc5)cc34)cn2)c1",
        "output": "949"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.COC(=O)CCCCCOc1ccc2nc(Cl)n(-c3ccccc3)c2c1>>COC(=O)CCCCCOc1ccc2nc(N3CCOCC3)n(-c3ccccc3)c2c1",
        "output": "36"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCCNCC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cl.O=C(O)Cc1cccc(CC(=O)O)c1.On1nnc2ccccc21>>O=C(O)Cc1cccc(CC(=O)N2CCCCCC2)c1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)CC(c1ccc(-c2ccccc2)cc1)n1cnc2cc(N)ccc21.Cl>>Nc1ccc2c(c1)ncn2C(CC(=O)O)c1ccc(-c2ccccc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Cl[Sn]Cl.O.O.O=[N+]([O-])c1ccc(-c2nc(N3CCSCC3)nc(N3C4CCC3COC4)n2)cc1.c1ccncc1>>Nc1ccc(-c2nc(N3CCSCC3)nc(N3C4CCC3COC4)n2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Nc1ccc2cnn(CCN3CCCC3)c2c1.O=C(O)CCc1ccc(OCc2ccccc2)cc1>>O=C(CCc1ccc(OCc2ccccc2)cc1)Nc1ccc2cnn(CCN3CCCC3)c2c1",
        "output": "365"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CCOC(=O)c1cn(C)c2nc3c(F)c(F)c(F)cc3cc2c1=O.Cl.O>>Cn1cc(C(=O)O)c(=O)c2cc3cc(F)c(F)c(F)c3nc21",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "O=C(Cl)Oc1ccccc1.Oc1ccccc1.[Al+3].[Ni+2].[OH-].[OH-].[OH-].[OH-].[OH-]>>O=C(Oc1ccccc1)Oc1ccccc1",
        "output": "261"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)Cc1ccc(C(=O)O)c(Cl)c1.Nc1ccc(Cl)c(-c2ccccn2)c1>>CS(=O)(=O)Cc1ccc(C(=O)Nc2ccc(Cl)c(-c3ccccn3)c2)c(Cl)c1",
        "output": "50"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4ccc(C5CCNCC5)cc4)cnc32)cc1.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4ccc(N5CCN(C(=O)OC(C)(C)C)CC5)c([N+](=O)[O-])c4)cnc32)cc1.Cl.O.[Li+].[OH-]>>CC(C)(C)OC(=O)N1CCN(c2ccc(-c3cnc4[nH]cc(-c5cnn(Cc6cccc(F)c6)c5)c4c3)cc2[N+](=O)[O-])CC1",
        "output": "949"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CI.Cc1cc(C)c(N2CCN(C(=O)c3ccc(N4C(=O)OC[C@H]4CO)nc3)CC2)nc1C>>COC[C@@H]1COC(=O)N1c1ccc(C(=O)N2CCN(c3nc(C)c(C)cc3C)CC2)cn1",
        "output": "140"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)COc1cccc2c1CC(NS(=O)(=O)c1ccccc1)CC2.O.[K+].[OH-]>>O=C(O)COc1cccc2c1CC(NS(=O)(=O)c1ccccc1)CC2",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cccc2c(=O)n(NC(=O)Nc3ccc(Br)cc3)cnc12.ClB(Cl)Cl.ClCCl.O=C([O-])O.[Na+]>>O=C(Nc1ccc(Br)cc1)Nn1cnc2c(O)cccc2c1=O",
        "output": "424"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)Cn2nc(-c3ccc(F)cc3)nc2-c2ccc(F)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(Cn1nc(-c2ccc(F)cc2)nc1-c1ccc(F)cc1)N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CC2CN(C(=O)OC(C)(C)C)CC(C1)N2.CCO.Fc1ccc(CCl)cc1.O=C([O-])[O-].[K+].[K+]>>CC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CC2CN(C(=O)OC(C)(C)C)CC(C1)N2Cc1ccc(F)cc1",
        "output": "156"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)CBr.Oc1cccc2c1CCC2>>COC(=O)COc1cccc2c1CCC2",
        "output": "557"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)Cn1c(=O)[nH]c2ccc(Cl)cc2c1=O.CN(C)C=O.Fc1cc(Br)ccc1CBr.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)Cn1c(=O)c2cc(Cl)ccc2n(Cc2ccc(Br)cc2F)c1=O",
        "output": "389"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.COc1ccc(F)c(-c2ccc(C3CCc4ccc(Br)cc4O3)cc2)c1.Cl[Pd]Cl.O.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1ccc(F)c(-c2ccc(C3CCc4ccc(B5OC(C)(C)C(C)(C)O5)cc4O3)cc2)c1",
        "output": "942"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C)=O.CCNc1ccc(C#N)cc1N=C1SC(=C2Sc3ccc(O)cc3N2C)C(=O)N1Cc1ccccc1.COC(=O)CBr.O=C([O-])[O-].[K+].[K+]>>CCNc1ccc(C#N)cc1N=C1SC(=C2Sc3ccc(OCC(=O)OC)cc3N2C)C(=O)N1Cc1ccccc1",
        "output": "557"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCN(c1ccncc1)n1cc(C)c2cc(O)ccc21.CN=C=O.O=C([O-])[O-].[K+].[K+]>>CCCN(c1ccncc1)n1cc(C)c2cc(OC(=O)NC)ccc21",
        "output": "104"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1ccc(-c2ccc(CN3CCOCC3)o2)c(C)c1.Cl>>Cc1cc(C(=O)O)ccc1-c1ccc(CN2CCOCC2)o1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)c1ccc(C#CC(C)(C)C)c(Cl)c1.CO.[Rh]>>CC(=O)c1ccc(CCC(C)(C)C)c(Cl)c1",
        "output": "717"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)c1cc2c(Cl)ccc(Oc3ccc([N+](=O)[O-])cc3)c2n1C.Cl[Sn]Cl.N.O.O.O>>CCOC(=O)c1cc2c(Cl)ccc(Oc3ccc(N)cc3)c2n1C",
        "output": "335"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc(C(C)C(=O)NCc2ccc(C(F)(F)F)nc2N2CCC(C)CC2)ccc1CNC(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>COc1cc(C(C)C(=O)NCc2ccc(C(F)(F)F)nc2N2CCC(C)CC2)ccc1CN",
        "output": "793"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.C1CCC2=NCCCN2CC1.CN(C)C=O.Cc1ccc2[nH]c(C(=O)O)cc2c1>>Cc1ccc2[nH]c(C(=O)OCc3ccccc3)cc2c1",
        "output": "403"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCC.CO.COc1ccc2ccc(C(=O)O)c(O)c2c1.FB(F)F>>COC(=O)c1ccc2ccc(OC)cc2c1O",
        "output": "195"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)C(=O)c1ccc(OCCOc2ccccc2)cc1.[Na+].[OH-]>>O=C(O)C(=O)c1ccc(OCCOc2ccccc2)cc1",
        "output": "506"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccccc1.NC(=O)c1cccc(C(F)(F)F)c1Cl.O.O=S(Cl)Cl>>N#Cc1cccc(C(F)(F)F)c1Cl",
        "output": "374"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=S(Cl)Cl.OCCc1cccnc1>>ClCCc1cccnc1",
        "output": "96"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCCN1CCC[C@H]1C.CC(C)NC(C)C.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Nc1ccc(Br)cc1I.[Cu]I>>C[C@@H]1CCCN1CCC#Cc1cc(Br)ccc1N",
        "output": "664"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)c1ccc(-c2cc(C)c3nc(OC)ccc3c2)cc1.Cl>>COC(=O)c1ccc(-c2cc(C)c3[nH]c(=O)ccc3c2)cc1",
        "output": "758"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCO.CN(C)CC(O)COc1ccc(N)cc1.CO.Cl.Clc1nccc(N2CCc3ccccc32)n1>>CN(C)CC(O)COc1ccc(Nc2nccc(N3CCc4ccccc43)n2)cc1",
        "output": "907"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(CN)(C(=O)Nc2ccc(F)cn2)CC1.Cl>>NCC1(C(=O)Nc2ccc(F)cn2)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.COc1cccc(Br)c1.S=C=S>>COc1ccc(C(C)=O)c(Br)c1",
        "output": "31"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCO.Cc1ccc(CO)cc1N.Clc1ccnc(Cl)n1>>Cc1ccc(CO)cc1Nc1ccnc(Cl)n1",
        "output": "161"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)Nc1cc2nc(-c3ccccc3)cn2cc1Br.ClCCl.O=C(O)C(F)(F)F>>Nc1cc2nc(-c3ccccc3)cn2cc1Br",
        "output": "782"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#CCNC(=O)c1cccc(F)c1Nc1nc(Cl)ncc1Cl.CC(=O)N1CCCOc2cc(N)ccc21.CC(C)O.CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.O=C([O-])[O-]>>C#CCNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)OCCCN3C(C)=O)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(C2Cc3cc(N4CCNCC4)ncc3O2)CC1.CCN(CC)CC.ClCCl.O=S(=O)(Cl)C1CC1>>CC(C)(C)OC(=O)N1CCC(C2Cc3cc(N4CCN(S(=O)(=O)C5CC5)CC4)ncc3O2)CC1",
        "output": "584"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.OCc1cc(C2CC2)c(OC(F)(F)F)c(C2CC2)c1>>O=Cc1cc(C2CC2)c(OC(F)(F)F)c(C2CC2)c1",
        "output": "179"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)c1ccn2ncc(C=O)c2c1.[Na+].[OH-]>>O=Cc1cnn2ccc(C(=O)O)cc12",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)cc1F.Sc1cccc2cnccc12.[K+].[K+]>>O=[N+]([O-])c1ccc(Cl)cc1Sc1cccc2cnccc12",
        "output": "675"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.CNC.O=C(O)Cc1ccc2nsnc2c1.O=C([O-])O.[Na+]>>CN(C)C(=O)Cc1ccc2nsnc2c1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOCC.C[Mg]Br.Cc1ccc2c(N3CCN(CCC(=O)c4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1>>Cc1ccc2c(N3CCN(CCC(C)(O)c4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1",
        "output": "586"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CO.Fc1ccccc1CBr.O[C@@H]1CCC[C@@H]1O.[H-].[H][H].[Na+]>>O[C@H]1CCC[C@H]1OCc1ccccc1F",
        "output": "464"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.Cl.N#Cc1ccnc(Cl)c1.OCCSc1nc[nH]n1.[H-].[Na+]>>N#Cc1ccnc(OCCSc2nc[nH]n2)c1",
        "output": "433"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.Cc1cc(C(=O)Nc2c(C)ccc(O)c2C)c(F)c(-c2cccc(F)c2)c1>>Cc1cc(CNc2c(C)ccc(O)c2C)c(F)c(-c2cccc(F)c2)c1",
        "output": "215"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC#N.CC(=O)[O-].CC(=O)c1cc(Cl)c2cccnc2c1N1CCC(Oc2ccccc2)CC1.CO.[BH3-]C#N.[NH4+].[Na+]>>CC(N)c1cc(Cl)c2cccnc2c1N1CCC(Oc2ccccc2)CC1",
        "output": "552"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C[AlH]CC(C)C.COC(=O)c1cccc2oc(C)cc12.ClCCl.[Na+].[OH-]>>Cc1cc2c(CO)cccc2o1",
        "output": "444"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.Nc1ccc2c(c1)CCN(C(=O)OCc1ccccc1)CC2.O=S(=O)(Cl)c1ccc(-c2ccccc2)cc1.c1ccncc1>>O=C(OCc1ccccc1)N1CCc2ccc(NS(=O)(=O)c3ccc(-c4ccccc4)cc3)cc2CC1",
        "output": "68"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1ccc(-c2ccc(OCC3CCN(CC(C)(C)F)CC3)c(C#N)c2)c(F)c1.O.O.[Li]O>>CC(C)(F)CN1CCC(COc2ccc(-c3ccc(C(=O)O)cc3F)cc2C#N)CC1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(CC)CC.CO.COC(=O)CCCc1ccc(OCC(=O)N(C)C)c(-c2ccccc2)c1.ClC(Cl)Cl.O>>CN(C)C(=O)COc1ccc(CCCC(=O)O)cc1-c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CO.COC(=O)c1c[nH]c(-c2ccc(F)cc2C(F)(F)F)c1C.Cl.[Na+].[OH-]>>Cc1c(C(=O)O)c[nH]c1-c1ccc(F)cc1C(F)(F)F",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)OC[C@H](C)N(c1ccccc1)C2.NO.[Na+].[OH-]>>C[C@H]1COc2cc(C(=O)NO)ccc2CN1c1ccccc1",
        "output": "988"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCO.Cl.ClCCNCCCl.Nc1ccc(F)c(F)c1.O=C([O-])[O-].[Na+].[Na+]>>Fc1ccc(N2CCNCC2)cc1F",
        "output": "640"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "NCCO.O=C(O)c1nc(Cl)c2ccccc2c1O>>O=C(NCCO)c1nc(Cl)c2ccccc2c1O",
        "output": "137"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)CN1CCC(C2CCN(C(=O)[C@@H](Cc3ccc(CC)c(CC)c3)NC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)CC1.Cl.[Na+].[OH-]>>CCc1ccc(C[C@@H](NC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(C3CCN(CC(=O)O)CC3)CC2)cc1CC",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCO.CCOC(=O)c1cc(C#N)c(N2CC(C(=O)O)C2)nc1C.ClCCl.NS(=O)(=O)Cc1ccccc1.O.O=S(=O)([O-])O.On1nnc2ccccc21.[K+]>>CCOC(=O)c1cc(C#N)c(N2CC(C(=O)NS(=O)(=O)Cc3ccccc3)C2)nc1C",
        "output": "644"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cl.ClCCN1CCCC1.Fc1ccc2[nH]nc(I)c2c1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>Fc1ccc2c(c1)c(I)nn2CCN1CCCC1",
        "output": "604"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.Cc1cc(-c2cccc(F)c2)cc(C(=O)Nc2c(F)ccc(O)c2C)c1F>>Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(O)c2C)c1F",
        "output": "215"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)N(C(=O)[O-])C1CCN(C(F)(F)F)C1.CC(C)(C)OC(=O)N[C@]1(C(F)(F)F)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2cncnc2)C1.CC(C)O.CCN(C(C)C)C(C)C.CCOC(C)=O.ClCCl.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(Cl)c(-c2cncnc2)c1.O=C(O)C(F)(F)F>>N[C@]1(C(F)(F)F)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2cncnc2)C1",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCCn1c(N2CCCN(CCC3(c4ccccc4)CCNC3)CC2)nc2ccccc21.CO.COc1ccc(-c2nnn[nH]2)cc1C(=O)O.Cl.ClCCl>>CCOCCn1c(N2CCCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(-c5nnn[nH]5)ccc4OC)C3)CC2)nc2ccccc21",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOCC.N#C[C@@]1(c2ccccc2)C[C@H]1COCc1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NC[C@@]1(c2ccccc2)C[C@H]1COCc1ccccc1",
        "output": "246"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)O.CNC.Cn1c(=O)cc(Cl)n(-c2cccc(C(F)(F)F)c2)c1=O>>CN(C)c1cc(=O)n(C)c(=O)n1-c1cccc(C(F)(F)F)c1",
        "output": "162"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)c1ccccn1.ClCCCl.Nc1ccccc1.O=C(O)c1cc(-c2ccccc2)c[nH]c1=O.Oc1cccc2[nH]nnc12>>O=C(Nc1ccccc1)c1cc(-c2ccccc2)c[nH]c1=O",
        "output": "739"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)C1CCC2(CC1)CC(O)(C#N)CO2.CO.Cl.O=C([O-])O.[H][H].[Na+]>>CC(C)(C)C1CCC2(CC1)CC(O)(CN)CO2",
        "output": "246"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1c(Cl)ccc(CNC(=O)C(C)C)c1F.CO.O.[Na+].[OH-]>>CC(C)C(=O)NCc1ccc(Cl)c(C(=O)O)c1F",
        "output": "5"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCN(CC)CCN.Clc1nc(Cl)c2ncn(C3CCCC3)c2n1>>CCN(CC)CCNc1nc(Cl)nc2c1ncn2C1CCCC1",
        "output": "145"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-n3cncn3)c2)cc1C(F)(F)F.ClCCl.O=C(O)C(F)(F)F>>CN(C)c1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-n3cncn3)c1)=N2",
        "output": "930"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)c1ccc(Oc2ccc(Br)cc2)cc1.C[Mg]Br>>CC(C)(O)c1ccc(Oc2ccc(Br)cc2)cc1",
        "output": "586"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CC(C)n1nc(C(=O)N[C@H]2C[C@@H](CN)N(C(=O)OC(C)(C)C)C2)c2ccccc21.CCN(CC)CC.ClCCl.O>>CC(=O)NC[C@@H]1C[C@H](NC(=O)c2nn(C(C)C)c3ccccc23)CN1C(=O)OC(C)(C)C",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.O=C1CCCc2cc(O)ccc21.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>O=C1CCCc2cc(OS(=O)(=O)C(F)(F)F)ccc21",
        "output": "731"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)C(NC(=O)c1cc(OCC(F)(F)F)c(C2CC2)cn1)C(=O)O.CNC.Cl>>CN(C)C(=O)C(NC(=O)c1cc(OCC(F)(F)F)c(C2CC2)cn1)C(C)(C)C",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=CBr)c1ccncc1.CN(C)C=O.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3.O=P([O-])([O-])[O-].O=S(=O)([O-])[O-].[Cu+2].[K+].[K+].[K+].c1cnc2c(c1)ccc1cccnc12>>C/C(=C\\n1c2c(c3cc(C)ccc31)CN(C)CC2)c1ccncc1",
        "output": "987"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)c1cccc(OC2CCN(Cc3ccccc3)CC2)c1.[Na+].[OH-]>>O=C(O)c1cccc(OC2CCN(Cc3ccccc3)CC2)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].COc1ncccc1C#N.[Na+]>>COc1ncc(Br)cc1C#N",
        "output": "292"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1cn(-c2cc3[nH]c(=O)[nH]c3cc2C)c(=O)[nH]c1=O.Cc1c(CBr)cccc1C(F)(F)F>>CCOC(=O)c1cn(-c2cc3[nH]c(=O)[nH]c3cc2C)c(=O)n(Cc2cccc(C(F)(F)F)c2C)c1=O",
        "output": "389"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)CCS(=O)(=O)N(C(=O)OC(C)(C)C)c1ccc(C(=O)O)cc1.CN(C)c1ccncc1.ClCCCl.ClCCl.[O-][n+]1cc(Cl)c(C[C@H](O)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1>>CN(C)CCS(=O)(=O)N(C(=O)OC(C)(C)C)c1ccc(C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)cc1",
        "output": "33"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O=[N+]([O-])c1cnccc1Cl.OCc1ccc(Cl)cc1>>O=[N+]([O-])c1cnccc1OCc1ccc(Cl)cc1",
        "output": "651"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C[Si](C)(C)[N-][Si](C)(C)C.Cc1c(Br)cnc(Cl)c1N.O.O=S(=O)(Cl)c1ccc(F)cc1F.[Li+]>>Cc1c(Br)cnc(Cl)c1NS(=O)(=O)c1ccc(F)cc1F",
        "output": "554"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1cc(-c2cccc(OC3CCCCO3)c2)cc2nn(C3CCCCO3)cc12.[Pd]>>Nc1cc(-c2cccc(OC3CCCCO3)c2)cc2nn(C3CCCCO3)cc12",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NC1CCCCC1.O=C(O)CNC(=O)c1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1>>O=C(CNC(=O)c1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1)NC1CCCCC1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.O=C1CCC(=O)N1Br.OCCCCc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>BrCCCCc1ccccc1",
        "output": "581"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCNC1.CCOC(=O)c1ccc(CBr)c(C(F)(F)F)c1.CCOC(=O)c1ccc(CN2CC[C@@H](NC(=O)OC(C)(C)C)C2)c(C(F)(F)F)c1.CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CC[C@@H](NC(=O)OC(C)(C)C)C2)c(C(F)(F)F)c1.[K+].[OH-]>>CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CC[C@H](N)C2)c(C(F)(F)F)c1",
        "output": "538"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(C)=O.NN.O.O.O=C1c2ccccc2C(=O)N1CCn1cc2c(-c3ccc(F)cc3)c(-c3ccncc3)c(-c3ccc(F)cc3)nc2n1>>NCCn1cc2c(-c3ccc(F)cc3)c(-c3ccncc3)c(-c3ccc(F)cc3)nc2n1",
        "output": "242"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)Cc1ccc(NC(=O)Nc2ccccc2Br)c(Cl)c1.[Na+].[OH-]>>O=C(O)Cc1ccc(NC(=O)Nc2ccccc2Br)c(Cl)c1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(C(=O)O)cc1/C=C/c1ccc(Br)cc1.NC(CO)CO>>COc1ccc(C(=O)NC(CO)CO)cc1/C=C/c1ccc(Br)cc1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccc(S(=O)(=O)n2cc(-c3ccc(-c4nnn[nH]4)cc3)c3cc(-c4ccccc4)cnc32)cc1.O.[F-]>>c1ccc(-c2cnc3[nH]cc(-c4ccc(-c5nnn[nH]5)cc4)c3c2)cc1",
        "output": "949"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC1(OCC)CCC(=O)CC1.ClCCCl.NCc1ccccc1.O=C([O-])O.[Na+].[Na+].[Na+].[OH-]>>CCOC1(OCC)CCC(NCc2ccccc2)CC1",
        "output": "589"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCOC(=O)C(c1ccc(CN2N=C(c3ccccc3)OCC2=O)cc1)C(C)C(F)(F)F.[Na+].[OH-]>>CC(C(C(=O)O)c1ccc(CN2N=C(c3ccccc3)OCC2=O)cc1)C(F)(F)F",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1cc(Cc2cccnc2)cc2cccnc12.O=[N+]([O-])c1cccc(B(O)O)c1>>O=[N+]([O-])c1cccc(-c2cc(Cc3cccnc3)cc3cccnc23)c1",
        "output": "833"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCBr.CC(C)(O)C(=O)c1ccc(O)cc1.CS(C)=O.O.[H-].[Na+]>>C=CCOc1ccc(C(=O)C(C)(C)O)cc1",
        "output": "77"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2ccc(N)cc2)C1.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[B-](F)(F)F.O=C(O)c1ccc(Cl)cn1>>CC(C)(C)OC(=O)N1CCC(c2ccc(NC(=O)c3ccc(Cl)cn3)cc2)C1",
        "output": "548"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CC(C)(C)[O-].Cc1cc(Cl)ccn1.Nc1ccc(O)cc1F.[K+]>>Cc1cc(Oc2ccc(N)c(F)c2)ccn1",
        "output": "351"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC[SiH](CC)CC.O=C(O)C(F)(F)F.O=C1COc2cc(C(=O)CCCBr)ccc2N1>>O=C1COc2cc(CCCCBr)ccc2N1",
        "output": "92"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ccc(Cl)cc1-c1ccc(Br)cc1.[Br-].[Li]CCCC>>C=Cc1ccc(Cl)cc1-c1ccc(Br)cc1",
        "output": "649"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.NC(=O)c1ccc(-c2ccc3[nH]cc(C[C@H]4CCCN4C(=O)OCc4ccccc4)c3c2)cc1>>NC(=O)c1ccc(-c2ccc3[nH]cc(C[C@H]4CCCN4)c3c2)cc1",
        "output": "428"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=C(Nc1ccc(F)cc1)N1CCNCC1.O=Cc1ccc2c(c1)OCO2>>O=C(Nc1ccc(F)cc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1",
        "output": "567"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCO.COC(=O)COc1ccc(NCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C.[Li+].[OH-]>>Cc1cc(NCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C)ccc1OCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CN(C)C=O.COc1cc(C=O)ccc1O.[H-].[Na+]>>COc1cc(C=O)ccc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1nc2c3c(c(C(=O)O)cc2n1C)CCC1(Cc2ccccc2C1)N3.F[B-](F)(F)F.OC1CNC1>>Cc1nc2c3c(c(C(=O)N4CC(O)C4)cc2n1C)CCC1(Cc2ccccc2C1)N3",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCCCOC(=O)c1ccc(=O)[nH]n1.O.O=C([O-])[O-].O=P(Cl)(Cl)Cl.[K+].[K+]>>CCCCOC(=O)c1ccc(Cl)nn1",
        "output": "537"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNC1.Cc1cccc(NC(=O)CN2C(=O)N(CC(=O)O)c3ccccc3N(C3CCCCCC3)C2=O)c1>>Cc1cccc(NC(=O)CN2C(=O)N(CC(=O)N3CCCC3)c3ccccc3N(C3CCCCCC3)C2=O)c1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)C(C)c1cccc(C(=O)c2ccccc2)c1.ClC(Cl)Cl.[BH4-].[Na+]>>COC(=O)C(C)c1cccc(C(O)c2ccccc2)c1",
        "output": "157"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.C1=CCCCC1.COc1ccc(S(=O)(=O)N2c3ccc(F)cc3-c3ccccc3C2C)cc1.ClCCl>>CC1c2ccccc2-c2cc(F)ccc2N1S(=O)(=O)c1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.COc1ccc(CCNc2nccc(-c3cccc([N+](=O)[O-])c3)n2)cc1OC.[C].[Pd]>>COc1ccc(CCNc2nccc(-c3cccc(N)c3)n2)cc1OC",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C[C@H](N)c1ccc(C(=O)OC(C)(C)C)cc1.N#Cc1cccc(Oc2ncc(Cl)cc2C(=O)O)c1>>C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(C#N)c1)c1ccc(C(=O)OC(C)(C)C)cc1",
        "output": "790"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(O)c1ccc(Br)cc1.O=S(Cl)Cl>>O=C(Cl)c1ccc(Br)cc1",
        "output": "3"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1c(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)cnn1C.Cl.O.[Na+].[OH-]>>Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCCCCCN.O=C=Nc1ccccc1>>CCCCCCCCNC(=O)Nc1ccccc1",
        "output": "35"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(O)c(C=O)c1.N=C(NN)c1ncccc1C(F)(F)F>>Cc1ccc(O)c(-c2nc(-c3ncccc3C(F)(F)F)n[nH]2)c1",
        "output": "994"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.COc1ccc2cc(C(=O)Nc3cccc(-c4ccc(F)cc4F)c3)[nH]c2c1.ClCCl>>O=C(Nc1cccc(-c2ccc(F)cc2F)c1)c1cc2ccc(O)cc2[nH]1",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#CCO.COc1ccc(Nc2ncc3c(n2)-c2ccc(I)cc2NC(=O)C3)cc1OC>>COc1ccc(Nc2ncc3c(n2)-c2ccc(C#CCO)cc2NC(=O)C3)cc1OC",
        "output": "664"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.Cc1nc(N(C)C)ccc1[N+](=O)[O-].[Ni]>>Cc1nc(N(C)C)ccc1N",
        "output": "269"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.C[C@H]1CNC[C@H](C)N1.Cl.Cl.ClCCl>>C[C@H]1CN(C(=O)OC(C)(C)C)C[C@H](C)N1",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.Oc1ccc2[nH]c3c(c2c1)CCSc1ccccc1-3>>CC(C)(C)[Si](C)(C)Oc1ccc2[nH]c3c(c2c1)CCSc1ccccc1-3",
        "output": "746"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(C)=O.COc1ccc(CCN)cc1Br.O=C(n1ccnc1)n1ccnc1.O=CO>>COc1ccc(CCNC=O)cc1Br",
        "output": "370"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCc1nc2c(cc1C(=O)OCC)C(=O)N(C1CCN(Cc3cc(C4CC4)c(-c4ccc(F)cc4)c(F)c3OCC)CC1)CC2.CCO.[Na+].[OH-]>>CCCc1nc2c(cc1C(=O)O)C(=O)N(C1CCN(Cc3cc(C4CC4)c(-c4ccc(F)cc4)c(F)c3OCC)CC1)CC2",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(C)c(CN)c(=O)[nH]1.Cc1nn(C2CCCCC2)c2nc(C3CC3)cc(C(=O)O)c12>>Cc1cc(C)c(CNC(=O)c2cc(C3CC3)nc3c2c(C)nn3C2CCCCC2)c(=O)[nH]1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCCl.O=S(=O)(c1ccc(Br)cc1)n1c(CO)cc2ccccc21.[Cl-].[Na+]>>O=Cc1cc2ccccc2n1S(=O)(=O)c1ccc(Br)cc1",
        "output": "263"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCCCC(CC(=O)OCC)c1sc2cc(C(F)(F)F)ccc2c1C.Cc1ccccc1.O.[H-]>>CCCCC(CCO)c1sc2cc(C(F)(F)F)ccc2c1C",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)O.CC(C)(C)OC(=O)N1CCCNCC1.CO.O=C1CCCCC1.[BH3-]C#N.[Na+]>>CC(C)(C)OC(=O)N1CCCN(C2CCCCC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(CCl)NC12CC3CC(CC(C3)C1)C2.c1ccc(CN2CCNCC2)cc1>>O=C(CN1CCN(Cc2ccccc2)CC1)NC12CC3CC(CC(C3)C1)C2",
        "output": "340"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=CC[C@](N)(Cc1ccccc1)C(=O)O.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.Cl.O.O=C([O-])O.[Na+]>>C=CC[C@@](Cc1ccccc1)(NC(=O)OC(C)(C)C)C(=O)O",
        "output": "626"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CCN(CC)CCNC(=O)c1c[nH]c(C=O)c1C.CCO.O=C1Cc2c(cccc2-c2cccc(Br)c2)N1>>CCN(CC)CCNC(=O)c1c[nH]c(C=C2C(=O)Nc3cccc(-c4cccc(Br)c4)c32)c1C",
        "output": "440"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC1(C)OB(c2cn[nH]c2)OC1(C)C.COCCBr.O=C([O-])[O-].[Cs+].[Cs+]>>COCCn1cc(B2OC(C)(C)C(C)(C)O2)cn1",
        "output": "577"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOCC.COC(=O)[C@H](Cc1ccc(OCCN(C)C(=O)OC(C)(C)C)cc1)NC(=O)[C@@H]1CC[C@@H](C(C)C)CC1.ClC(Cl)Cl.ClCCl.O=C(O)C(F)(F)F>>CNCCOc1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](C(C)C)CC2)C(=O)OC)cc1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NCCCNC(c1nc2cc(Cl)ccc2nc1Cc1ccccc1)C1CC1.CCN(CC)CC.Cc1ccc(C(=O)Cl)cc1.ClCCl>>Cc1ccc(C(=O)N(CCCNC(=O)OC(C)(C)C)C(c2nc3cc(Cl)ccc3nc2Cc2ccccc2)C2CC2)cc1",
        "output": "201"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Fc1ccccn1.OC1CCN(Cc2cc(Br)ccc2OCc2ccc(Cl)cc2)CC1.[H-].[Na+]>>Clc1ccc(COc2ccc(Br)cc2CN2CCC(Oc3ccccn3)CC2)cc1",
        "output": "541"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cn2cc(NC(=O)C(C[C@@H]3CCCCO3)n3cc(OC)c(-c4cc(Cl)ccc4C#N)cc3=O)ccc2n1.[Li+].[OH-]>>COc1cn(C(C[C@@H]2CCCCO2)C(=O)Nc2ccc3nc(C(=O)O)cn3c2)c(=O)cc1-c1cc(Cl)ccc1C#N",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C(=O)c1cc2c(s1)-c1ccc(Br)cc1OCC2)c1ccccc1Cl.Nc1cccc(B(O)O)c1>>CN(C(=O)c1cc2c(s1)-c1ccc(-c3cccc(N)c3)cc1OCC2)c1ccccc1Cl",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.Cn1c2cc(Cl)ccc2c2c(CO)nn(-c3ccccc3)c(=O)c21.[Mn+4].[O-2].[O-2]>>Cn1c2cc(Cl)ccc2c2c(C=O)nn(-c3ccccc3)c(=O)c21",
        "output": "573"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNC.O=S1(=O)N(CCOCCBr)c2ccccc2N1c1ccccc1F>>CN(C)CCOCCN1c2ccccc2N(c2ccccc2F)S1(=O)=O",
        "output": "73"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)CC1CCNCC1.O.O=[N+]([O-])c1cc(Cl)ccc1Cl>>CCOC(=O)CC1CCN(c2ccc(Cl)cc2[N+](=O)[O-])CC1",
        "output": "105"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Nc1nc2ccc(-c3ccccc3C(=O)C3CCOCC3)cc2cc1N1CCOCC1.[BH4-].[Na+]>>Nc1nc2ccc(-c3ccccc3C(O)C3CCOCC3)cc2cc1N1CCOCC1",
        "output": "24"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.CCO.COc1cc(-c2nc(C)no2)cc([N+](=O)[O-])c1OC.ClCCl>>Cc1noc(-c2cc(O)c(O)c([N+](=O)[O-])c2)n1",
        "output": "19"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)CCSC(c1ccccc1)C1(OC)CCOCC1.O>>COC1(C(SCCC(=O)O)c2ccccc2)CCOCC1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.ClC(Cl)Cl.O=C1CCCCC1c1ccccc1Cl>>O=C1C(Br)CCCC1c1ccccc1Cl",
        "output": "82"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC1(C(=O)O)CCCC1.CCOC(C)=O.CN(C)C=O.ClCCCl.O.O.On1nnc2ccccc21.[NH4+].[OH-]>>CC(C)(C)OC(=O)NC1(C(N)=O)CCCC1",
        "output": "313"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NNc1cnc2ccc(Br)cc2n1.O=C(O)C1CC1>>O=C(NNc1cnc2ccc(Br)cc2n1)C1CC1",
        "output": "459"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.O=C([O-])[O-].OCCCCCCCl.Oc1ccc(Cc2ccccc2)cc1.[K+].[K+].[Na+].[OH-]>>OCCCCCCOc1ccc(Cc2ccccc2)cc1",
        "output": "74"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CCCN1C2CCC1CC(=O)C2.CO.CS(=O)(=O)n1ncc2cc(N)ccc21.[BH3-]C#N.[Na+].[Na+].[OH-]>>CCCN1C2CCC1CC(Nc1ccc3c(cnn3S(C)(=O)=O)c1)C2",
        "output": "469"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=Cc1cc(Cl)cc(Br)c1O.O=c1cc(N2CCNCC2)nc[nH]1>>O=c1cc(N2CCN(Cc3cc(Cl)cc(Br)c3O)CC2)nc[nH]1",
        "output": "567"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)CCC=C[C@@H]1CC[C@@H](c2cccc(F)c2F)CC1.CCOC(C)=O>>CCOC(=O)CCCC[C@@H]1CC[C@@H](c2cccc(F)c2F)CC1",
        "output": "143"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)C(=C(c1ccc(F)cc1)c1ccc(F)cc1)c1nnn(C(C)(C)C)n1.Cl.ClCCl.[H-]>>CC(C)(C)n1nnc(C(CO)=C(c2ccc(F)cc2)c2ccc(F)cc2)n1",
        "output": "150"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN1CCOCC1.Cc1ccc(C(=O)O)s1.Cl.ClCCl.Clc1ccc(C(c2ccccc2)N2CCNCC2)cc1>>Cc1ccc(C(=O)N2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)s1",
        "output": "857"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cl.NCCNC(=O)N1CCOCC1.[Na+].[OH-].c1cc(OCC2CO2)ccc1OCCOCC1CC1>>O=C(NCCNCC(O)COc1ccc(OCCOCC2CC2)cc1)N1CCOCC1",
        "output": "16"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.COc1cc(N)ccc1C1CC1.ClCCl>>Nc1ccc(C2CC2)c(O)c1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1ccc(Cc2c(C)cc3c(c2C)C(C)(C)CCO3)o1.Cl.O>>Cc1cc2c(c(C)c1Cc1ccc(C(=O)O)o1)C(C)(C)CCO2",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)Oc1cc(Cl)ccc1[N+](=O)[O-].CO.NN.O.[Ni]>>CC(C)Oc1cc(Cl)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.NS(=O)(=O)C1CC1.O=C(O)c1cc(Cl)c(F)cc1F.O=C(n1ccnc1)n1ccnc1>>O=C(NS(=O)(=O)C1CC1)c1cc(Cl)c(F)cc1F",
        "output": "580"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOC(C)=O.CN(C)C=O.Cc1c(N[C@@H](C(=O)NNC(=O)c2ccc3[nH]ccc3c2)[C@H](C)O)ccc(C#N)c1Cl.O.c1c[nH]cn1>>Cc1c(N[C@@H](C(=O)NNC(=O)c2ccc3[nH]ccc3c2)[C@H](C)O[Si](C)(C)C(C)(C)C)ccc(C#N)c1Cl",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1ccc(C[C@H](NC(=O)[C@H](C)N)C(=O)OCc2ccccc2)cc1.F[P-](F)(F)(F)(F)F.O=C(O)CN1CCOCC1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)OCc2ccccc2)cc1",
        "output": "133"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.Cc1ccccc1-c1n[nH]c(N)c1C.ClCCCl.O=C(O)CCCN1CCCC1>>Cc1ccccc1-c1n[nH]c(NC(=O)CCCN2CCCC2)c1C",
        "output": "795"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC.CCOCC.CO.Cc1ccc(S(=O)(=O)O)cc1.O.O.O=C(O)CCCCCCc1ncsc1C(=O)O>>COC(=O)CCCCCCc1ncsc1C(=O)O",
        "output": "195"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C(=O)Cl.CN(C)c1ccncc1.N#CC1(c2cccc(C(=O)Nc3cc(Oc4ccc5nc(N)sc5n4)ccc3F)c2Cl)CC1.O.c1ccncc1>>CC(C)C(=O)Nc1nc2ccc(Oc3ccc(F)c(NC(=O)c4cccc(C5(C#N)CC5)c4Cl)c3)nc2s1",
        "output": "553"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.Cl.O=C1CCCN(C(=O)c2ccc([N+](=O)[O-])cc2)c2ccsc21.[Fe].[Na+].[OH-]>>Nc1ccc(C(=O)N2CCCC(=O)c3sccc32)cc1",
        "output": "28"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN.O=C(O)c1cccc(F)c1F.O=S(Cl)Cl>>CNC(=O)c1cccc(F)c1F",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N(C)C.CN(C)CC#C[C@@H]1CC[C@@H](N(C)c2ccc(Cl)nn2)CC1.C[O-].[Na+]>>COc1ccc(N(C)[C@@H]2CC[C@@H](C#CCN(C)C)CC2)nn1",
        "output": "407"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.N#Cc1c(-c2cccnc2)[nH]c2cc(F)ccc12.O=C([O-])O.[H-].[Na+].[Na+]>>Cn1c(-c2cccnc2)c(C#N)c2ccc(F)cc21",
        "output": "191"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.C1CCOC1.COc1cc(C(=O)O)c(Cl)cc1Cl.O>>COc1cc(CO)c(Cl)cc1Cl",
        "output": "72"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.N#Cc1cccc(S(=O)(=O)Cl)c1.NCCc1ccc(Br)cc1>>N#Cc1cccc(S(=O)(=O)NCCc2ccc(Br)cc2)c1",
        "output": "43"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.c1ccc(CN2CC(c3ccccc3)OC3(CCNCC3)C2)cc1>>CC(C)(C)OC(=O)N1CCC2(CC1)CN(Cc1ccccc1)CC(c1ccccc1)O2",
        "output": "694"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2ccc(-c3ccnc(N)c3)nc2n1.c1ccncc1>>CC(=O)Nc1cc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)ccn1",
        "output": "394"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#CCOc1ccc(CCN)cc1OC.CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cl.F[P-](F)(F)(F)(F)F.O=C(CC(O)C(=O)O)c1ccc(Cl)cc1>>C#CCOc1ccc(CCNC(=O)C(O)CC(=O)c2ccc(Cl)cc2)cc1OC",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(=O)Cl.CC(=O)OCc1ccc(C2C(C)C(=O)N(OCC[Si](C)(C)C)S2(=O)=O)c(Br)c1.CO>>CC1C(=O)N(OCC[Si](C)(C)C)S(=O)(=O)C1c1ccc(CO)cc1Br",
        "output": "497"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#CC[C@H](NC(=O)OC(C)(C)C)C(=O)OC.CCNCC.CCOCC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Fc1ccccc1COc1ccc(Br)nc1.I[Cu]I>>COC(=O)[C@H](CC#Cc1ccc(OCc2ccccc2F)cn1)NC(=O)OC(C)(C)C",
        "output": "777"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COc1c([N+](=O)[O-])cc(C(C)(C)C)cc1[N+](=O)[O-].O=C[O-].[NH4+].[Pd]>>COc1c(N)cc(C(C)(C)C)cc1N",
        "output": "204"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CNC1CCn2c(nc(C(=O)NCc3ccc(F)cc3)c(O)c2=O)C1.Cl.ClCCl.O.On1nnc2ccccc21>>CC(=O)N(C)C1CCn2c(nc(C(=O)NCc3ccc(F)cc3)c(O)c2=O)C1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)CCCCl.Cl.OCc1nc2c(s1)-c1ccccc1Sc1ccc(F)cc1-2>>CN(C)CCCOCc1nc2c(s1)-c1ccccc1Sc1ccc(F)cc1-2",
        "output": "308"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "N#CCc1ccnc(Cl)c1[N+](=O)[O-].c1ccc(CN2CCNCC2)cc1>>N#CCc1ccnc(N2CCN(Cc3ccccc3)CC2)c1[N+](=O)[O-]",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1ccc(OCc2ccccc2)c(OC)c1.[Na+].[OH-]>>COc1cc(C(=O)O)ccc1OCc1ccccc1",
        "output": "222"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(OCC)[C@H](C)N(Cc1cccc2cccnc12)C(=O)[C@@H](N)Cc1ccc(OC(C)(C)C)cc1.O=C(O)CONC(=O)NCc1ccc(Cl)cc1>>CCOC(OCC)[C@H](C)N(Cc1cccc2cccnc12)C(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)CONC(=O)NCc1ccc(Cl)cc1",
        "output": "133"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCC.CCOC(C)=O.C[Mg]Br.Cc1c(C)c2c(c(C)c1NC(=O)CC(C)(C)C)C(c1ccc(C=O)cc1)CO2>>Cc1c(C)c2c(c(C)c1NC(=O)CC(C)(C)C)C(c1ccc(C(C)O)cc1)CO2",
        "output": "787"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.COC(=O)Cl.COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC1CCNCC1.ClCCl>>COC(=O)N1CCC(Oc2cc3c(Nc4cccc(Cl)c4F)ncnc3cc2OC)CC1",
        "output": "219"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCO.Cc1ccc2ccc(C(=O)O)c(O)c2n1.ClCCl.[K+].[OH-]>>CCCCOC(=O)c1ccc2ccc(C)nc2c1O",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.COC(=O)Cl.ClCCl.Nc1cccc(N2CCN(Cc3ccccc3)CC2)c1.O>>COC(=O)Nc1cccc(N2CCN(Cc3ccccc3)CC2)c1",
        "output": "102"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)n1ccc2ccc([N+](=O)[O-])cc21.CO.[BH4-].[Na+]>>CC(C)(C)OC(=O)n1ccc2ccc(N)cc21",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl.NCc1ccc(F)cc1Cl.O=C(O)[C@@H]1CCC(=O)N1Cc1ccccc1.On1nnc2ccccc21>>O=C(NCc1ccc(F)cc1Cl)[C@@H]1CCC(=O)N1Cc1ccccc1",
        "output": "797"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CC[C@@H](NC(=O)c2cn3ccccc3n2)CC1.Cl>>N[C@@H]1CC[C@H](NC(=O)c2cn3ccccc3n2)CC1",
        "output": "538"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2ccc(OCC3CCN(CC(C)(C)F)CC3)c(C#N)c2)cn1.O.O.[Li]O>>CC(C)(F)CN1CCC(COc2ccc(-c3ccc(C(=O)O)nc3)cc2C#N)CC1",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C(=O)O)(c1ccccc1)c1ccccc1.NCCCN1CCC(c2cccc(NC(=O)C3CC3)c2)CC1>>CC(C(=O)NCCCN1CCC(c2cccc(NC(=O)C3CC3)c2)CC1)(c1ccccc1)c1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOCC.CO.COc1cccc2c(Cl)nccc12.COc1ccccc1.Cc1ccccc1N>>COc1cccc2c(Nc3ccccc3C)nccc12",
        "output": "434"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(=O)Cc1cccc2[nH]c(=O)n(-c3cccc(S(=O)(=O)N4CCCc5ccccc54)c3)c(=O)c12.[Na+].[OH-]>>O=C(O)Cc1cccc2[nH]c(=O)n(-c3cccc(S(=O)(=O)N4CCCc5ccccc54)c3)c(=O)c12",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1c([C@@H](O)CN2C3CCC2CC(N)C3)ccc2c1COC2=O.Cl.O=C(O)c1ccc(-n2cnnn2)nc1>>Cc1c([C@@H](O)CN2C3CCC2CC(NC(=O)c2ccc(-n4cnnn4)nc2)C3)ccc2c1COC2=O",
        "output": "674"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)[N-]C(C)C.CN(C)C=O.COc1ccc(F)cc1Br.[Li+]>>COc1ccc(F)c(C=O)c1Br",
        "output": "239"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.COc1cc(C(=O)C(C)C)ccc1O.ClCCl.O=[N+]([O-])O>>COc1cc(C(=O)C(C)C)cc([N+](=O)[O-])c1O",
        "output": "21"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.CS(=O)(=O)Nc1cc(Br)cc(C(=O)c2ccnc(Cl)c2)c1.C[O-].[Na+]>>COc1cc(C(=O)c2cc(Br)cc(NS(C)(=O)=O)c2)ccn1",
        "output": "433"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)CNC(=O)CNC(=O)CN.CCCCCCCCCCCCCCCC(=O)OCC(CSCCC(=O)O)OC(=O)CCCCCCCCCCCCCCC.CCN(CC)CC.CCOP(=O)(C#N)OCC.CN(C)C=O.Cl.O>>CCCCCCCCCCCCCCCC(=O)OCC(CSCCC(=O)NCC(=O)NCC(=O)NCC(=O)OC(C)(C)C)OC(=O)CCCCCCCCCCCCCCC",
        "output": "133"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(CCN)cc1OC.O=CC1CC1>>COc1ccc(CCNCC2CC2)cc1OC",
        "output": "426"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cl[Sn]Cl.N#CCc1ccc([N+](=O)[O-])c(Cl)c1Br.O.O.O=C([O-])O.[Na+]>>N#CCc1ccc(N)c(Cl)c1Br",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(F)cc1CN(c1ccc(C#N)c(Cl)c1)[C@H]1CCNC1.O=S(=O)(Cl)Cc1ccccc1>>Cc1ccc(F)cc1CN(c1ccc(C#N)c(Cl)c1)[C@H]1CCN(S(=O)(=O)Cc2ccccc2)C1",
        "output": "584"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.O=C([O-])[O-].OCCBr.Oc1cccc(Nc2ncc(-c3ccc(OC(F)F)cc3)cn2)c1.[Cs+].[Cs+]>>OCCOc1cccc(Nc2ncc(-c3ccc(OC(F)F)cc3)cn2)c1",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1cn(Cc2ccc(OC)cc2OC)c2nc(N3CC(O)C(NCc4ccccc4)C3)c(F)cc2c1=O.O.O.[Li+].[OH-]>>COc1ccc(Cn2cc(C(=O)O)c(=O)c3cc(F)c(N4CC(O)C(NCc5ccccc5)C4)nc32)c(OC)c1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CN(C)C=O.O.O=C(O)c1cccc(C(=O)O)n1.O=C([O-])O.[Na+]>>O=C(O)c1cccc(C(=O)OCc2ccccc2)n1",
        "output": "403"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCN1Cc2cc(Oc3cccc(CN)c3)ccc2N=C1NC(=O)OC(C)(C)C.Cc1cc(C)c(C=O)c(C)c1.ClCCCl.O=C([O-])O.[Na+].[Na+]>>CCCN1Cc2cc(Oc3cccc(CNCc4c(C)cc(C)cc4C)c3)ccc2N=C1NC(=O)OC(C)(C)C",
        "output": "683"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.COCCl.O.O=[N+]([O-])c1cc2c(cc1O)CCC2>>COCOc1cc2c(cc1[N+](=O)[O-])CCC2",
        "output": "375"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=O.CC(=O)CC(C)C.CCc1ccccc1.CO.O=S(=O)(O)O.c1ccc2ccccc2c1>>O=Cc1cccc2ccccc12",
        "output": "451"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Cl.NO.O.O=Cc1ccc(F)cc1.[Na+].[OH-]>>ON=Cc1ccc(F)cc1",
        "output": "30"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1c(F)cc([N+](=O)[O-])cc1Br.Cl>>Cc1c(F)cc(N)cc1Br",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN=C=NCCCN(C)C.CN1CCCc2ccc(N)cc21.Cl.ClCCl.O.O=C(O)c1ccc(-c2ccccc2)nc1.On1nnc2ccccc21>>CN1CCCc2ccc(NC(=O)c3ccc(-c4ccccc4)nc3)cc21",
        "output": "739"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.Oc1ccccc1O.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1ccccc1O",
        "output": "746"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.CCc1cc(Cl)c2cccc(OC)c2n1.N>>CCc1cc(Cl)c2cccc(O)c2n1",
        "output": "424"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "O=C(O)c1cc2ncc(Cl)cn2n1.c1coc(-c2ccc3n2CCNC3)c1>>O=C(c1cc2ncc(Cl)cn2n1)N1CCn2c(ccc2-c2ccco2)C1",
        "output": "663"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)O)cc3)c(Cl)cc21.CN(C)C=O.NCCc1ccccc1.O>>CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)NCCc4ccccc4)cc3)c(Cl)cc21",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc2c(Cl)nc(Nc3cc(C)[nH]n3)cc2c1.Oc1ccc(Cl)cc1>>COc1ccc2c(Oc3ccc(Cl)cc3)nc(Nc3cc(C)[nH]n3)cc2c1",
        "output": "516"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N(C)C.Cl[Pd]Cl.Nc1cc(Br)cc(-c2ccc(F)cc2F)c1.O.O=C([O-])[O-].OB(O)c1ccc(F)nc1.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Nc1cc(-c2ccc(F)nc2)cc(-c2ccc(F)cc2F)c1",
        "output": "899"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccccc1.Nc1ccc(Cl)cc1Cl.O=C(O)c1cc(S(=O)(=O)Cl)ccc1Cl.[Na+].[OH-]>>O=C(O)c1cc(S(=O)(=O)Nc2ccc(Cl)cc2Cl)ccc1Cl",
        "output": "68"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.NCCCN1CCOCC1.O=C(NC(Cc1ccccc1)C(=O)O)c1cc2cc(Cl)ccc2[nH]1>>O=C(NC(Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1cc2cc(Cl)ccc2[nH]1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C1CCOC1.CCOCC.NC(=O)C12CCCN(CCC1)C2.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>NCC12CCCN(CCC1)C2",
        "output": "112"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN1C(C)(C)CC(N)CC1(C)C.COc1cc(C(=O)O)ccc1-c1cc2cc(Cl)c(Cl)cc2[nH]1.O.On1nnc2cccnc21>>COc1cc(C(=O)NC2CC(C)(C)N(C)C(C)(C)C2)ccc1-c1cc2cc(Cl)c(Cl)cc2[nH]1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COc1cnc2[nH]cc(-c3cc(Cl)nc(NC4CCC(CC5CCC(N)CC5)CC4)c3)c2c1.O=C1CCCCC1.[BH3-]C#N.[Cl-].[Cl-].[Na+].[Zn+2]>>COc1cnc2[nH]cc(-c3cc(Cl)nc(NC4CCC(CC5CCC(NC6CCCCC6)CC5)CC4)c3)c2c1",
        "output": "236"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COc1ccc(CCl)cc1.O.O=C([O-])[O-].O=C1CCCc2cc(O)ccc21.[Cs+].[Cs+]>>COc1ccc(COc2ccc3c(c2)CCCC3=O)cc1",
        "output": "49"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)CN1CCN(C(=O)c2ccc(F)cc2)CC1.NN>>NNC(=O)CN1CCN(C(=O)c2ccc(F)cc2)CC1",
        "output": "164"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.C[C@H]1CO[C@@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(OCOC(=O)OCCCOCc4ccccc4)c3C(=O)N12.O=C(OCI)OCCCOCc1ccccc1.O=C([O-])[O-].O=S(=O)([O-])O.[K+].[K+]>>C[C@H]1CO[C@@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(OCOC(=O)OCCCO)c3C(=O)N12",
        "output": "178"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.N#Cc1cc(C=O)ccc1Oc1cccc(C(F)(F)F)c1.[BH4-].[Na+]>>N#Cc1cc(CO)ccc1Oc1cccc(C(F)(F)F)c1",
        "output": "356"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.COC(=O)c1cccc(CC(=O)O)c1.Cl.ClCCl.NCC1CN(Cc2ccc(Cl)c(Cl)c2)CCO1.On1nnc2ccccc21>>COC(=O)c1cccc(CC(=O)NCC2CN(Cc3ccc(Cl)c(Cl)c3)CCO2)c1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CON(C)C(=O)c1ccc(CN(C(=O)OC(C)(C)C)[C@@H]2CC[C@@H](C(C)(C)C)CC2)cc1.ClCCl.O=C(O)C(F)(F)F>>CON(C)C(=O)c1ccc(CN[C@@H]2CC[C@@H](C(C)(C)C)CC2)cc1",
        "output": "887"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCS(=O)(=O)Cl.ClCCl.NC1CCCc2c(Br)cncc21>>CCS(=O)(=O)NC1CCCc2c(Br)cncc21",
        "output": "493"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CC(C)(O)c1ccccc1CC[C@H](O)c1cccc(C=Cc2ccc3ccc(Cl)cc3n2)c1.CCN(CC)CC.ClCCl>>CC(=O)O[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1",
        "output": "254"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1c1ncc(-c2cnc(-c3ccc(-c4cnc([C@@H]5CCCN5C(=O)OCc5ccccc5)[nH]4)cc3)nc2)[nH]1.CO.O.O=C([O-])[O-].[K+].[K+].[Pd]>>CC(C)(C)OC(=O)N1CCC[C@H]1c1ncc(-c2cnc(-c3ccc(-c4cnc([C@@H]5CCCN5)[nH]4)cc3)nc2)[nH]1",
        "output": "428"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#C[Si](C)(C)C.C1CCOC1.CCN(C(C)C)C(C)C.COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1I.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1C#C[Si](C)(C)C",
        "output": "826"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN1C(=O)CCc2cc(Br)ccc21.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CN1C(=O)CCc2cc(B3OC(C)(C)C(C)(C)O3)ccc21",
        "output": "942"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CNc1cc(-c2ccc(Cl)c3c(NS(C)(=O)=O)nn(C)c23)c([C@@H](N)Cc2cc(F)cc(F)c2)nc1C#CC(C)(C)O.CSc1ncc(-c2cccc3c(N)nn(C)c23)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)F)c3c2C(F)(F)CCC3(F)F)n1.O=C(O)Cn1nc(C(F)F)c2c1C(F)(F)[C@@H]1C[C@H]21>>CNc1cc(-c2ccc(Cl)c3c(NS(C)(=O)=O)nn(C)c23)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)F)c3c2C(F)(F)[C@@H]2C[C@H]32)nc1C#CC(C)(C)O",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)c1cc(Br)nc2c1c(CC)nn2C(C)C.[Na+].[OH-]>>CCc1nn(C(C)C)c2nc(Br)cc(C(=O)O)c12",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)C[C@H]1CN(C(=O)c2ccc(Oc3ccccc3)cc2)[C@@H](CC(C)C)C(=O)N1.CC(C)[C@@H]1NC[C@H](c2ccccc2)NC1=O.O=C(O)[C@@H]1C[C@H]1c1ccccc1>>CC(C)[C@H]1C(=O)N[C@@H](c2ccccc2)CN1C(=O)[C@@H]1C[C@H]1c1ccccc1",
        "output": "297"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCBr.CCC(C)=O.COC(=O)C(C)(C)Cc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>C=CCOc1ccc(CC(C)(C)C(=O)OC)cc1",
        "output": "77"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(C)Oc1ccc(O)c(Cl)c1.CN(C)C=O.ClCc1ccc(Cl)cc1.O=C([O-])[O-].[K+].[K+]>>CCC(C)Oc1ccc(OCc2ccc(Cl)cc2)c(Cl)c1",
        "output": "49"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cl.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3OCC4)CC2)CC1.O=C(O)c1ccccc1>>O=C(N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3OCC4)CC2)CC1)c1ccccc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cc1nc(-c2nn3ccccc3c2-c2ccnc(F)c2)cs1.NC1CCCC1.O=C([O-])[O-].[K+].[K+]>>Cc1nc(-c2nn3ccccc3c2-c2ccnc(NC3CCCC3)c2)cs1",
        "output": "810"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(F)(F)c1coc(CN)n1.COc1ccc(C[C@H]2NC(=O)n3c2nc2ccccc23)cc1>>COc1ccc(C[C@@H](NC(=O)NCc2nc(C(C)(F)F)co2)c2nc3ccccc3[nH]2)cc1",
        "output": "999"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(COCc2cc(C(F)(F)F)cc3cc[nH]c23)(c2ccccc2)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CN1CCC(COCc2cc(C(F)(F)F)cc3cc[nH]c23)(c2ccccc2)CC1",
        "output": "881"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.O.[N-]=[N+]=N[C@H]1CCCC[C@H]1Oc1ccc(Br)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N[C@H]1CCCC[C@H]1Oc1ccc(Br)cc1",
        "output": "89"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)O.[Na+].[OH-]>>CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)O",
        "output": "631"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.COc1cc(C)c2c(c1C)C(O)CC2.[Pd]>>COc1cc(C)c2c(c1C)CCC2",
        "output": "447"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCC(C)(C)CO.CCOCC.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CCCCCCC(C)(C)C=O",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.COCOc1ccc(-c2noc(C3(CN4CCN(C)CC4)CC3)c2-c2ccccc2)cc1.Cl.[Na+].[OH-]>>CN1CCN(CC2(c3onc(-c4ccc(O)cc4)c3-c3ccccc3)CC2)CC1",
        "output": "755"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNCCC(=O)OC(C)(C)C.N#Cc1ccc(CBr)cc1>>CN(CCC(=O)OC(C)(C)C)Cc1ccc(C#N)cc1",
        "output": "248"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)c1cnc2ccc(Cl)nc2c1Nc1ccc(N2CCC[C@H](NC(=O)OC(C)(C)C)C2)nc1.CC1(C)OB(c2cc(F)c(O)c(Cl)c2)OC1(C)C>>CC(=O)c1cnc2ccc(-c3cc(F)c(O)c(Cl)c3)nc2c1Nc1ccc(N2CCC[C@H](NC(=O)OC(C)(C)C)C2)nc1",
        "output": "955"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)Cc1cc([N+](=O)[O-])c(F)cc1C#N.CCOC(C)=O.CO.[Pd]>>CCOC(=O)Cc1cc(N)c(F)cc1C#N",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)CCc1ccc(OCOC)cc1Oc1ccc(C(F)(F)F)cn1.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>COCOc1ccc(CCCO)c(Oc2ccc(C(F)(F)F)cn2)c1",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.CO.COc1c2n(c3c(N(C)S(C)(=O)=O)cn(Cc4ccc(F)c(Cl)c4)c(=O)c13)CCN(C)C2=O.ClCCl>>CN1CCn2c(c(O)c3c(=O)n(Cc4ccc(F)c(Cl)c4)cc(N(C)S(C)(=O)=O)c32)C1=O",
        "output": "424"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1CCNC(C)C1.CCN(CC)CC.Cl.O>>CC1CCN(C(=O)OC(C)(C)C)C(C)C1",
        "output": "694"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCC1CCc2cc(CO)ccc2C1.CCN(CC)CC.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.O=S(=O)(c1ccc2cc(Cl)ccc2c1)N1CCNCC1.O=[Cr](=O)([O-])Cl.[Na+].c1cc[nH+]cc1>>CC(C)(C)OC(=O)NCC1CCc2cc(CN3CCN(S(=O)(=O)c4ccc5cc(Cl)ccc5c4)CC3)ccc2C1",
        "output": "765"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.OCCc1cccc(I)c1.c1ccncc1>>CC(=O)OCCc1cccc(I)c1",
        "output": "254"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.CNC.F[P-](F)(F)(F)(F)F.O=C(O)CN1C(=O)N(c2ccccc2Cl)Cc2cnc(SCc3ccccc3)nc21.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CN(C)C(=O)CN1C(=O)N(c2ccccc2Cl)Cc2cnc(SCc3ccccc3)nc21",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)[C@@H](C)N.CCN(CC)CC.CCN(CC)CCCNc1nc(-c2cc(C(=O)O)ccc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F>>CCN(CC)CCCNc1nc(-c2cc(C(=O)N[C@H](C)C(C)C)ccc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NC1=NC(CO)CS1.CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCC2CSC(NC(=O)OC(C)(C)C)=N2)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=CCC(C(O)CC(=O)OC)C1CCCC1.CO.[K+].[OH-]>>C=CCC(C(O)CC(=O)O)C1CCCC1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CCCC#Cc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N2CCCCC2)cc1.CCOC(C)=O.[Pd+2]>>CC(C)(C)OC(=O)CCCCCc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N2CCCCC2)cc1",
        "output": "717"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1c(C)n(CCN2CCOCC2)c2ccccc12.CCO.CCOC(C)=O.O=Cc1ccccc1F.[K+].[OH-]>>Cc1c(C(=O)C=Cc2ccccc2F)c2ccccc2n1CCN1CCOCC1",
        "output": "295"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1ncc2c(c1O)CCN(Cc1ccc(OC)cc1OC)C2=O.C[O-].NCCC(=O)O.O=C([O-])O.[Na+].[Na+]>>COc1ccc(CN2CCc3c(cnc(C(=O)NCCC(=O)O)c3O)C2=O)c(OC)c1",
        "output": "487"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.COc1c(Cl)ccc2ccc(O)nc12.O.O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+]>>COc1c(Cl)ccc2ccc(Cl)nc12",
        "output": "41"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=C(O)c1cccc(-c2ccccc2)c1O.O=S(=O)(O)O>>COC(=O)c1cccc(-c2ccccc2)c1O",
        "output": "33"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COCOc1ccc(C2(C)COc3cc(OCOC)ccc3C2CCCCCCCCCO[Si](C)(C)C(C)(C)C)cc1.COCOc1ccc2c(c1)OCC(C)C2C#CCCCCCCCO[Si](C)(C)C(C)(C)C>>COCOc1ccc2c(c1)OCC(C)(c1ccc(O)cc1)C2CCCCCCCCCO[Si](C)(C)C(C)(C)C",
        "output": "755"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.O=C1CCC(=O)N1Br.c1csc(-c2ccc(-c3cccs3)[nH]2)c1>>Brc1cc(-c2cccs2)[nH]c1-c1cccs1",
        "output": "796"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.Cl.Nc1ccccc1.O.O.O=C1CCNCC1.[Zn]>>c1ccc(NC2CCNCC2)cc1",
        "output": "469"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN1CCN(C)C[C@@H](N)C1.CN(C)C=O.CNc1nc(OC)c(C(=O)O)cc1Br>>CCN1CCN(C)C[C@@H](NC(=O)c2cc(Br)c(NC)nc2OC)C1",
        "output": "674"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Br.CC(=O)O.CCO.Cc1cc(Cl)ccc1-n1nc(C(=O)OCC(Cl)(Cl)Cl)c(C)c1-c1ccc(OCc2ccccc2)cc1>>Cc1cc(Cl)ccc1-n1nc(C(=O)OCC(Cl)(Cl)Cl)c(C)c1-c1ccc(O)cc1",
        "output": "23"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCNCC(O)(CNc1cccc2c1cnn2-c1ccccc1)C(F)(F)F.O=C(O)c1ccccc1F>>CCN(CC(O)(CNc1cccc2c1cnn2-c1ccccc1)C(F)(F)F)C(=O)c1ccccc1F",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CO.COC(=O)c1cnc(N2CCN(S(=O)(=O)c3ccc(-c4ccccc4)cc3)CC2)s1.C[O-].Cl.Cl.NO.[Na+]>>O=C(O)c1cnc(N2CCN(S(=O)(=O)c3ccc(-c4ccccc4)cc3)CC2)s1",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)O.CC(C)(C)O.CCN(CC)CC.CCOCC.ClCCCl.ClCCCl.FC(F)(F)c1cnc(Cl)nc1Cl.Nc1ccc2c(c1)C(F)(F)C(=O)N2.[Cl-].[Cl-].[Zn+2]>>O=C1Nc2ccc(Nc3ncc(C(F)(F)F)c(Cl)n3)cc2C1(F)F",
        "output": "808"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNC1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CCOC(C)=O.CN(C)C=O.N#Cc1ccc(Br)cc1.[Na+].[Pd+2]>>N#Cc1ccc(N2CCCC2)cc1",
        "output": "294"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCCCCCCCCOCCOCCOP(=O)([O-])OCCBr.c1ccncc1>>CCCCCCCCCCCCCCOCCOCCOP(=O)([O-])OCC[n+]1ccccc1",
        "output": "470"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1ccc(C(=O)O)cc1Cl.Cl.NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O.O.O=C(n1ccnc1)n1ccnc1>>Cc1ccc(C(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1Cl",
        "output": "753"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.N#Cc1ccc(C(=O)O)c(F)c1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(C#N)cc1F",
        "output": "415"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "B.C1CCOC1.C1CCOC1.C=C[C@H]1C[C@@H]1c1ccc(Br)cc1.OO>>OCC[C@H]1C[C@@H]1c1ccc(Br)cc1",
        "output": "465"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)[C@H](CN)NS(=O)(=O)c1ccc(-c2ccc(S(=O)(=O)NCCNC(=O)OCc3ccccc3)cc2)cc1.O=C(O)c1ccc2c(cnn2CCCNc2ncccn2)c1>>COC(=O)[C@H](CNC(=O)c1ccc2c(cnn2CCCNc2ncccn2)c1)NS(=O)(=O)c1ccc(-c2ccc(S(=O)(=O)NCCNC(=O)OCc3ccccc3)cc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCC(O)C2)c(Br)c1.OB(O)c1cccnc1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCC(O)C2)c(-c2cccnc2)c1",
        "output": "883"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(O)c1ccn2c(Br)cnc2n1.OB(O)c1cccc(-c2cccnc2)c1F>>CC(C)(O)c1ccn2c(-c3cccc(-c4cccnc4)c3F)cnc2n1",
        "output": "876"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)CC1C2CCCC1CCC2.CO.[Na+].[OH-]>>O=C(O)CC1C2CCCC1CCC2",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "NC[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)c1nc(N)sc1-c1cccc(F)c1.O=C(O)c1cnc2sccn12>>Nc1nc(C(=O)N2[C@H](CNC(=O)c3cnc4sccn34)C[C@@H]3C[C@@H]32)c(-c2cccc(F)c2)s1",
        "output": "697"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(B2OC(C)(C)C(C)(C)O2)cn1.COC(=O)c1cnc(F)c(Br)c1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Na+].[Na+].[Pd].[Pd]>>CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(-c2cc(C(=O)OC)cnc2F)cn1",
        "output": "967"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCC(=O)N(Cc1ccc(C#Cc2ccc(CCCC)cc2)cc1)Cc1ccc(C(=O)OC)cc1.[Na+].[OH-]>>CCCCCC(=O)N(Cc1ccc(C#Cc2ccc(CCCC)cc2)cc1)Cc1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CS(=O)(=O)N1CCNCC1.ClCCl.F[P-](F)(F)(F)(F)F.N#Cc1ccc(N2N=C3c4ccc(C(=O)O)nc4CCC3C2C2CCCC2)cc1Cl>>CS(=O)(=O)N1CCN(C(=O)c2ccc3c(n2)CCC2C3=NN(c3ccc(C#N)c(Cl)c3)C2C2CCCC2)CC1",
        "output": "605"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)Cc1ccccc1OCc1cccc(-c2cccc([C@H](N)CO)c2Cl)c1.ClCCl.O=C(O)C(F)(F)F>>N[C@H](CO)c1cccc(-c2cccc(COc3ccccc3CC(=O)O)c2)c1Cl",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1ccccc1Br.CC(C)=O.CCOC(C)=O.CO.O.[BH4-].[Na+]>>CC(O)c1ccccc1Br",
        "output": "24"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O.Cl.O=S(=O)(c1cccnc1)c1cnc(N2CCNCC2)s1>>CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ncc(S(=O)(=O)c3cccnc3)s2)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)C1CN(S(=O)(=O)c2ccc3cc(Cl)ccc3c2)CCN1C(=O)c1nc2c(s1)CNC(C)C2.O.[Na+].[OH-]>>CC1Cc2nc(C(=O)N3CCN(S(=O)(=O)c4ccc5cc(Cl)ccc5c4)CC3C(=O)O)sc2CN1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(-c2cc(CCl)on2)c(O)c1.Fc1cccc(-c2nc3cn[nH]cc-3n2)c1F>>COc1ccc(-c2cc(Cn3cc4nc(-c5cccc(F)c5F)nc-4cn3)on2)c(O)c1",
        "output": "997"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(=O)[O-].CO.Nc1ccc(S(=O)(=O)O)cc1.O.O.O.O.O=C(c1ccccc1)c1ccc(CBr)cc1.[Na+]>>O=C(c1ccccc1)c1ccc(CNc2ccc(S(=O)(=O)O)cc2)cc1",
        "output": "272"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(=O)OC(C)=O.Cl.Cl.Clc1cccc(Nc2ncnc3[nH]nc(N4CCNCC4)c23)c1.O.O=C([O-])[O-].[K+].[K+]>>CC(=O)N1CCN(c2n[nH]c3ncnc(Nc4cccc(Cl)c4)c23)CC1",
        "output": "369"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)CCNc1cc(F)cc(-c2ccnc(N)c2[N+](=O)[O-])c1.CO.[Pd]>>CN(C)CCNc1cc(F)cc(-c2ccnc(N)c2N)c1",
        "output": "269"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C(=O)O)n1ccc(-c2cc(Cl)ccc2C#N)cc1=O.Cn1c(=O)c2ccc(N)cc2n1C(=O)OC(C)(C)C>>CC(C(=O)Nc1ccc2c(=O)n(C)n(C(=O)OC(C)(C)C)c2c1)n1ccc(-c2cc(Cl)ccc2C#N)cc1=O",
        "output": "365"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccccc1O.Cc1cc(Nc2cc3ccccc3c(Cl)n2)n[nH]1>>COc1ccccc1Oc1nc(Nc2cc(C)[nH]n2)cc2ccccc12",
        "output": "516"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(N)CO.CN(C)C=O.Cn1c(Cl)nc2nn(Cc3ccc(-c4ccccc4)cc3)cc2c1=O>>Cn1c(NC(C)(C)CO)nc2nn(Cc3ccc(-c4ccccc4)cc3)cc2c1=O",
        "output": "544"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.COC(OC)OC.CS(=O)(=O)N1CCNCC1.Cn1c(C=O)nc2c(N3CCOCC3)nc(Cl)nc21.[Na+]>>Cn1c(CN2CCN(S(C)(=O)=O)CC2)nc2c(N3CCOCC3)nc(Cl)nc21",
        "output": "944"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN[C@@H](COc2ccc3ccccc3c2)C1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)[O-].COc1ccccc1COCCCOc1ccc(Br)cc1.Cc1ccccc1.[K+].[Pd]>>COc1ccccc1COCCCOc1ccc(N2CCN(C(=O)OC(C)(C)C)C[C@@H]2COc2ccc3ccccc3c2)cc1",
        "output": "294"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.C[C@@](O)(C(=O)Nc1cccc(N)c1Cl)C(F)(F)F.O.O=N[O-].O=S(=O)(O)O.[I-].[K+].[Na+]>>C[C@@](O)(C(=O)Nc1cccc(I)c1Cl)C(F)(F)F",
        "output": "200"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)CCC(=O)c1ccc(OCc2cc(C)ccc2C)cc1.[Na+].[OH-]>>Cc1ccc(C)c(COc2ccc(C(=O)CCC(=O)O)cc2)c1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNCC1.Cl.O=C(O)c1cc2cc(OCCCN3CCCCC3)cnc2[nH]1>>O=C(c1cc2cc(OCCCN3CCCCC3)cnc2[nH]1)N1CCCCC1",
        "output": "605"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(C)cc1N.FC(F)(F)c1cc(Cl)nc(-c2ccccn2)n1>>COc1ccc(C)cc1Nc1cc(C(F)(F)F)nc(-c2ccccn2)n1",
        "output": "161"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)N1CCNCC1.COc1cc(N2CCC(=O)CC2)ccc1[N+](=O)[O-]>>COc1cc(N2CCC(N3CCN(C(C)C)CC3)CC2)ccc1[N+](=O)[O-]",
        "output": "187"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1ncc2cc(Oc3ccccn3)ccc2c1O.C[O-].NCCC(=O)O.[Na+]>>O=C(O)CCNC(=O)c1ncc2cc(Oc3ccccn3)ccc2c1O",
        "output": "487"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.O=CCCCOc1ccc2c(n1)NC(=O)CC2.O=c1ccc2cccc(N3CCNCC3)c2[nH]1>>O=C1CCc2ccc(OCCCCN3CCN(c4cccc5ccc(=O)[nH]c45)CC3)nc2N1",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrC(Br)(Br)Br.ClCCl.OCCOCCOCCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>OCCOCCOCCBr",
        "output": "378"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(C(C)C)C(C)C.CN(C)C=O.Cc1cnn(CCC2CCNCC2)c1.Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)O)n1>>Cc1cnn(CCC2CCN(C(=O)/C=C/c3ccc(Cl)cc3Cn3nnc(C)n3)CC2)c1",
        "output": "811"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1sc(NOC(=O)OC(C)(C)C)nc1C(F)(F)F.CO.Cl.[Na+].[OH-]>>CC(C)(C)OC(=O)ONc1nc(C(F)(F)F)c(C(=O)O)s1",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOP(=O)(C#N)OCC.Cn1cc(C(=O)O)cc1-c1c2c(=O)n(C)c(=O)n(CC3CC3)c2nn1Cc1ccnc2ccc(Cl)cc12.NC1CC1>>Cn1cc(C(=O)NC2CC2)cc1-c1c2c(=O)n(C)c(=O)n(CC3CC3)c2nn1Cc1ccnc2ccc(Cl)cc12",
        "output": "674"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COc1cc(C=O)ccc1OCc1nc(-c2ccco2)oc1C.O.[BH4-].[Na+]>>COc1cc(CO)ccc1OCc1nc(-c2ccco2)oc1C",
        "output": "356"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)C(C)(C)Oc1ccc(O)cc1C.CCOC(=O)C(C)(C)Oc1ccc(OCC(=O)O)cc1C.COC(=O)CCl.Nc1cccc(-c2ccc(C(F)(F)F)cc2)c1>>CCOC(=O)C(C)(C)Oc1ccc(OCC(=O)Nc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1C",
        "output": "365"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.COC(C)O.COc1cc2ncc(C#N)c(Cl)c2cc1[N+](=O)[O-].Nc1ccc(F)c(Cl)c1>>COc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1[N+](=O)[O-]",
        "output": "115"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Fc1ccc(Br)cc1.O=C1CCC2(CC1)OCCO2.[Mg]>>OC1(c2ccc(F)cc2)CCC2(CC1)OCCO2",
        "output": "321"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNC1.C1CSCN1.O=C(CC1CCc2ccccc21)C1SCN[C@@H]1C(=O)O.O=C(C[C@@H]1CCc2ccccc2C1)C1SCN[C@@H]1C(=O)O>>O=C(C[C@@H]1CCc2ccccc2C1)C1SCN[C@@H]1C(=O)N1CCCC1",
        "output": "685"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCOC(=O)c1cc(Oc2ccc3[nH]ccc3c2)ncn1.O.[BH3-]C#N.[Na+]>>CCOC(=O)c1cc(Oc2ccc3c(c2)CCN3)ncn1",
        "output": "672"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCN(C2CCNCC2)CC1.C1COCCO1.CCN(CC)CC.O=[N+]([O-])c1ccc(F)cc1>>O=[N+]([O-])c1ccc(N2CCC(N3CCCCC3)CC2)cc1",
        "output": "26"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O=[N+]([O-])c1ccc(S)cc1.OCCBr.[Na+].[OH-]>>O=[N+]([O-])c1ccc(SCCO)cc1",
        "output": "124"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OCc1csc(Nc2ccc(Oc3ccccc3)cn2)n1.CCO.O.[Na+].[OH-]>>OCc1csc(Nc2ccc(Oc3ccccc3)cn2)n1",
        "output": "348"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1ccc(NC(=O)C(CCOC)n2cc(OC)c(-c3cc(Cl)ccc3C#N)cc2=O)cc1.CO.O.O=C([O-])[O-].[Cs+].[Cs+]>>COCCC(C(=O)Nc1ccc(C(=O)O)cc1)n1cc(OC)c(-c2cc(Cl)ccc2C#N)cc1=O",
        "output": "5"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOP(=O)(CO)OCC.CN(C)C=O.O=[N+]([O-])c1cc(Br)ccc1F.[Na]>>CCOP(=O)(COc1ccc(Br)cc1[N+](=O)[O-])OCC",
        "output": "485"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccccc1Br.C1COCCO1.CCOCCO.O=C([O-])[O-].OB(O)c1ccc2c(c1)c1ccccc1n2-c1ccccc1.[Na+].[Na+].c1ccc([PH](c2ccccc2)(c2ccccc2)[Pd-4]([PH](c2ccccc2)(c2ccccc2)c2ccccc2)([PH](c2ccccc2)(c2ccccc2)c2ccccc2)[PH](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Brc1ccccc1-c1ccc2c(c1)c1ccccc1n2-c1ccccc1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)N=C=O.Nc1ccc2c(c1)CCC(=O)N2.c1ccccc1>>CC(C)NC(=O)Nc1ccc2c(c1)CCC(=O)N2",
        "output": "176"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cc(S(=O)(=O)N(C)C)ccc1B(O)O.Clc1ccccc1-c1cc2nc(Br)cnc2[nH]1>>Cc1cc(S(=O)(=O)N(C)C)ccc1-c1cnc2[nH]c(-c3ccccc3Cl)cc2n1",
        "output": "876"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cc1c(-c2ccnc(Cl)n2)sc2ccc(Cl)cc12.[NH4+].[OH-]>>Cc1c(-c2ccnc(N)n2)sc2ccc(Cl)cc12",
        "output": "312"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCCCCCCC(=O)Cl.CCN(CC)CC.Cl.Cl.ClCCl.NCCCSc1ccncc1>>CCCCCCCCCCCC(=O)NCCCSc1ccncc1",
        "output": "45"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NCCC(O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1.O=C(O)c1ccc2[nH]c(=O)sc2c1>>O=C(NCCC(O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1ccc2[nH]c(=O)sc2c1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)C(=O)Cl.CCN(C(C)C)C(C)C.CN(C)c1ccncc1.ClCCl.NC(c1ccc2ccc(-c3ccccc3)nc2c1)c1nccnc1Cl>>CC(C)(C)C(=O)NC(c1ccc2ccc(-c3ccccc3)nc2c1)c1nccnc1Cl",
        "output": "206"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC[Sn](CCCC)(CCCC)c1ccc(OC)cc1[N+](=O)[O-].CCO.COc1ccc(-c2nc3ccc(OC)cc3s2)c([N+](=O)[O-])c1.COc1ccc2nc(Cl)sc2c1.Cl.Cl[Sn]Cl.N.O.O>>COc1ccc(-c2nc3ccc(OC)cc3s2)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(O)(CC)c1ccc(C)cc1Br.CCN(C(C)C)C(C)C.COCCl.ClCCl.[Cl-].[NH4+]>>CCC(CC)(OCOC)c1ccc(C)cc1Br",
        "output": "598"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OB(c2ccc(C3(C(F)(F)F)CC3)cc2)OC1(C)C.Cn1cnc(-c2cc(C#N)ccn2)c1Br>>Cn1cnc(-c2cc(C#N)ccn2)c1-c1ccc(C2(C(F)(F)F)CC2)cc1",
        "output": "937"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COC(C)(C)C.COCC(C)Oc1cc(C#N)cc(Oc2ccc(S(C)(=O)=O)cc2)c1.Cl.O.[Na+].[OH-]>>COCC(C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(C(=O)O)c1",
        "output": "445"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.OCc1ccc(OC(F)(F)F)cc1>>O=Cc1ccc(OC(F)(F)F)cc1",
        "output": "179"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.Cl.O.O=C(O)CCCC1CCCCN1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCCCC1CCCC(=O)O",
        "output": "694"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCN(CC1CC1)c1cc(C(=O)O)ncn1.CCN(C(C)C)C(C)C.COC(=O)Cl.Cc1nccn1-c1cccc(N)c1.ClCCl>>CCCN(CC1CC1)c1cc(C(=O)Nc2cccc(-n3ccnc3C)c2)ncn1",
        "output": "548"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CCN(CC)CC.CCOC(C)=O.ClCCl.NC1CCN(CCCOCCc2ccc3sccc3c2)C1.O>>CC(=O)NC1CCN(CCCOCCc2ccc3sccc3c2)C1",
        "output": "45"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)[C@H](Cc1ccc(OCCCCc2ccc([N+](=O)[O-])cc2)cc1)OCC.O.[Li+].[OH-]>>CCO[C@@H](Cc1ccc(OCCCCc2ccc([N+](=O)[O-])cc2)cc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CCn1nc(C)cc1CCCN.CN(C)C=O.Cc1ccc(CCC(=O)O)cc1C.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CCn1nc(C)cc1CCCNC(=O)CCc1ccc(C)c(C)c1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)C1(C(=O)O)CCN(C(=O)OC(C)(C)C)CC1.Cl>>COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)C1(C(=O)O)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.O.O=Cc1ccc(OCCOc2cnc(-c3ccccc3)c(-c3ccccc3)n2)cc1.[BH4-].[Na+]>>OCc1ccc(OCCOc2cnc(-c3ccccc3)c(-c3ccccc3)n2)cc1",
        "output": "356"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc(Nc2nc(N)c3scc(-c4cccc(NC(=O)NC(C)C)c4)c3n2)cc(OC)c1OC.CS(=O)(=O)Cl.Nc1cccc(-c2csc3c(N)nc(Cl)nc23)c1>>CS(=O)(=O)Nc1cccc(-c2csc3c(N)nc(Cl)nc23)c1",
        "output": "194"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=O.CCC(NCCCn1ccnc1)c1ccc(Cl)cc1.O=C(O)C(=O)O.O=CO>>CCC(c1ccc(Cl)cc1)N(C)CCCn1ccnc1",
        "output": "69"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.CN(C)C1CCC(Oc2cccc3sc4c(c23)CNCC4)CC1.ClCCl.O=C(O)C(F)(F)F>>CC(=O)N1CCc2sc3cccc(OC4CCC(N(C)C)CC4)c3c2C1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)[N-]C(C)C.COc1cccc(F)c1C#N.O=C=O.[Li+]>>COc1ccc(C(=O)O)c(F)c1C#N",
        "output": "387"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CBr.CCc1ccccc1O.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)COc1ccccc1CC",
        "output": "123"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C(=O)Cl.ClCCl.N#Cc1ccc(CCCNCCO)cc1.O>>CN(C)C(=O)N(CCO)CCCc1ccc(C#N)cc1",
        "output": "258"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)Cc1ccc(NS(C)(=O)=O)cc1.CO.O.O.[Li+].[OH-]>>CS(=O)(=O)Nc1ccc(CC(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNCCN1.O=S1CCN(c2nc(Cl)nc3nc(N4CCOCC4)c(Cl)nc23)CC1>>O=S1CCN(c2nc(N3CCNCC3)nc3nc(N4CCOCC4)c(Cl)nc23)CC1",
        "output": "36"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "B.C1CCOC1.C1CCOC1.CCC(=O)N1CC(c2ccc(NS(=O)(=O)c3ccc(OC(F)(F)F)cc3)cc2)C1>>CCCN1CC(c2ccc(NS(=O)(=O)c3ccc(OC(F)(F)F)cc3)cc2)C1",
        "output": "112"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)Nc1ccc2c(c1)C[C@@H](CO)C2.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OC[C@H]2Cc3ccc(NC(=O)OC(C)(C)C)cc3C2)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1cc(-c2ccc(C(O)(c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)C(C)C)cc2)cc(C(F)(F)F)c1.Cl.c1ccncc1>>CC(=O)Nc1cc(-c2ccc(C(O)(c3c[nH]cn3)C(C)C)cc2)cc(C(F)(F)F)c1",
        "output": "838"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.N[C@@H]1CC[C@@H](NC(=O)c2c[nH]c3c(-c4ccc(F)cc4OCC4CC4)ncnc23)CC1>>CC(=O)N[C@@H]1CC[C@@H](NC(=O)c2c[nH]c3c(-c4ccc(F)cc4OCC4CC4)ncnc23)CC1",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCC(=O)c1cc2ccc(O)cc2oc1=O.CI.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCCC(=O)c1cc2ccc(OC)cc2oc1=O",
        "output": "62"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CCC(C(=O)c1ccc(C2OCCO2)cc1)C1CCCCC1.Cl>>C=CCC(C(=O)c1ccc(C=O)cc1)C1CCCCC1",
        "output": "655"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cl.Clc1ccc(-n2ccnc2)nn1.OC1CCCN(Cc2ccccc2)C1.[H-].[Na+]>>c1ccc(CN2CCCC(Oc3ccc(-n4ccnc4)nn3)C2)cc1",
        "output": "407"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCC.N#Cc1ncc([N+](=O)[O-])cc1C(F)(F)F.[Au]>>N#Cc1ncc(N)cc1C(F)(F)F",
        "output": "269"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1cc2c(-c3ccc4c5c(ccnc35)CCO4)c([C@H](OC(C)(C)C)C(=O)OC)c(C)cn2n1.[Na+].[OH-]>>COC(=O)[C@@H](OC(C)(C)C)c1c(C)cn2nc(C(=O)O)cc2c1-c1ccc2c3c(ccnc13)CCO2",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)COc1ccc(SC(CCc2ccccc2)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C.Cl.[Na+].[OH-]>>Cc1cc(SC(CCc2ccccc2)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)ccc1OCC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)COc1cccc2c1CCCCC2NS(=O)(=O)c1cc(F)cc(C(F)(F)F)c1.[Na+].[OH-]>>O=C(O)COc1cccc2c1CCCCC2NS(=O)(=O)c1cc(F)cc(C(F)(F)F)c1",
        "output": "278"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](N)CC1.Cc1[nH]c2c(-c3cc(C(F)F)ccc3OCC3CC3)ncnc2c1C(=O)O>>Cc1[nH]c2c(-c3cc(C(F)F)ccc3OCC3CC3)ncnc2c1C(=O)N[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1",
        "output": "737"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1nc(CCOCc2ccccc2)n(Cc2ccncc2)c1Sc1cc(Cl)cc(Cl)c1.Cl.O=C([O-])O.[Na+]>>CC(C)c1nc(CCO)n(Cc2ccncc2)c1Sc1cc(Cl)cc(Cl)c1",
        "output": "178"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C(=O)c1cnc2ccc(Br)cc2c1N1CCC(CN2CCCC2)CC1.OB(O)c1ccc(O)c(Cl)c1>>CC(C)C(=O)c1cnc2ccc(-c3ccc(O)c(Cl)c3)cc2c1N1CCC(CN2CCCC2)CC1",
        "output": "837"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)N(CCCl)C(C)C.COc1ccc(-c2ccc3cc(OC)ccc3c2)c(C(=O)c2ccc(O)cc2)c1.Cl>>COc1ccc(-c2ccc3cc(OC)ccc3c2)c(C(=O)c2ccc(OCCN(C(C)C)C(C)C)cc2)c1",
        "output": "74"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1cc(C(=O)NC2(C(=O)O)CC2)cc(C(C)(C)C)c1O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.NCc1nccs1>>CC(C)(C)c1cc(C(=O)NC2(C(=O)NCc3nccs3)CC2)cc(C(C)(C)C)c1O",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)c1ccc2c(c1)C(=O)OC2=O.COC(=O)C(CN)C1(C)OCCO1>>COC(=O)C(CN1C(=O)c2ccc(C(C)(C)C)cc2C1=O)C1(C)OCCO1",
        "output": "341"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CO.COC(=O)C1(O)CCNCC1.ClCCl>>COC(=O)C1(O)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cl.ClCCl.N#CCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.O.[Na+].[OH-]>>O=C(O)Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1",
        "output": "259"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C(=O)c1ccsc1.CO.O.[Na+].[OH-]>>O=C(O)C(=O)c1ccsc1",
        "output": "472"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CC(c2n[nH]c3c2CNCC3)C1.Cl.ClCCl.O=C=Nc1cccc(Cl)c1>>O=C(Nc1cccc(Cl)c1)N1CCc2[nH]nc(C3CCC3)c2C1",
        "output": "323"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCN(C(C)C)C(C)C.O=P(Cl)(Cl)Cl.O=[N+]([O-])c1cnc2ccc(Cl)cc2c1O>>O=[N+]([O-])c1cnc2ccc(Cl)cc2c1Cl",
        "output": "177"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)C(C)(C)C(C)Nc1c(C(N)=O)cnn2cc(-c3ccccc3)cc12.O.[K+].[OH-]>>CC(Nc1c(C(N)=O)cnn2cc(-c3ccccc3)cc12)C(C)(C)C(=O)O",
        "output": "361"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.[N-]=[N+]=N[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)C[C@H]1O.[Pd]>>N[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)C[C@H]1O",
        "output": "89"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)CCCBr.CN(C)C=O.Cc1ccc(-c2c(CNC(=O)OC(C)(C)C)c(CC(C)C)nc(C)c2C(=O)O)cc1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CCCOC(=O)c1c(C)nc(CC(C)C)c(CNC(=O)OC(C)(C)C)c1-c1ccc(C)cc1",
        "output": "416"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(Cc1nc2ccccc2n1CCCN)C1CCCc2cccnc21.N#CCCCn1c(CN(CCc2ccccc2)C2CCCc3cccnc32)nc2ccccc21>>NCCCCn1c(CN(CCc2ccccc2)C2CCCc3cccnc32)nc2ccccc21",
        "output": "246"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.COc1ccc2c(c1)CC(O)CC2.O=S(=O)(O)O>>COc1ccc2c(c1)CC(OC(C)=O)CC2",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1ccc(CN2CCC(CNC(=O)c3n[nH]c4ccc(Br)cc34)CC2)o1.COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4nc(C(=O)O)cs4)CC3)c2c1>>O=C(O)c1ccc(CN2CCC(CNC(=O)c3n[nH]c4ccc(Br)cc34)CC2)o1",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCOP(=O)(C#N)OCC.Cl.ClCCl.O.O=C(O)c1ccc2c(c1)S(=O)(=O)c1ccccc1C2=O.c1cc2c(o1)CCNC2>>O=C1c2ccccc2S(=O)(=O)c2cc(C(=O)N3CCc4occc4C3)ccc21",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C1CNCCN1.ClCc1cccc(Oc2ccccc2)c1>>c1ccc(Oc2cccc(CN3CCNCC3)c2)cc1",
        "output": "156"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.NCCCNc1nsc2ccccc12.O=C(Cl)c1ccc(Cl)cc1>>O=C(NCCCNc1nsc2ccccc12)c1ccc(Cl)cc1",
        "output": "271"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCc1cnc(N2CCC(COC3CNC3)CC2)nc1.CN1CCCC1=O.CS(=O)(=O)c1ncc2c(n1)CCN(S(C)(=O)=O)C2.Cl>>CCc1cnc(N2CCC(COC3CN(c4ncc5c(n4)CCN(S(C)(=O)=O)C5)C3)CC2)nc1",
        "output": "679"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.Nc1ccc(-n2ccc(-c3ccccn3)n2)c(F)c1.O.O=C(Cl)OCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>O=C(Nc1ccc(-n2ccc(-c3ccccn3)n2)c(F)c1)OCc1ccccc1",
        "output": "509"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.ClCCl.Nc1ccc(SCc2csc(N)n2)cc1.O=C(OO)c1cccc(Cl)c1>>Nc1ccc(S(=O)Cc2csc(N)n2)cc1",
        "output": "500"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COc1cc(Br)cc(C=O)c1.[C-]#N.[C-]#N.[Zn+2]>>COc1cc(C#N)cc(C=O)c1",
        "output": "65"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OCC(=O)Nc1cncc(-c2ccc3c(c2)CCC(=O)N3C)c1.CO.O=C([O-])[O-].[Na+].[Na+]>>CN1C(=O)CCc2cc(-c3cncc(NC(=O)CO)c3)ccc21",
        "output": "687"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCNCC.COCCc1nc2c(N)nc3ccccc3c2n1CCCN(Cc1cccc(OC2(C(=O)OC)CC2)c1)C(=O)CCl.Cl>>CCN(CC)CC(=O)N(CCCn1c(CCOC)nc2c(N)nc3ccccc3c21)Cc1cccc(OC2(C(=O)OC)CC2)c1",
        "output": "340"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)C1(O)CCOc2ccc(Cl)cc21.O.O.[Li]O>>O=C(O)C1(O)CCOc2ccc(Cl)cc21",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(N2CCN[C@@H](Cc3ccccc3)C2)cc1OC1CCC1.O=C(O)Cc1nn[nH]n1>>COc1ccc(N2CCN(C(=O)Cc3nn[nH]n3)[C@@H](Cc3ccccc3)C2)cc1OC1CCC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)C(=O)COc1ccccc1.ClCCl.O=C(Cl)CCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CCN(CC)C(=O)COc1ccc(C(=O)CCl)cc1",
        "output": "31"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)/C(=N\\OCC(=O)N(CC)CC)c1csc(N)n1.CO.O.[Na+].[OH-]>>CCN(CC)C(=O)CO/N=C(\\C(=O)O)c1csc(N)n1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.O=C(O)CCc1cccc(Br)c1>>OCCCc1cccc(Br)c1",
        "output": "231"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C=C(C)C(=O)NCC(=O)NCC(=O)O.CN(C)C=O.O=[N+]([O-])c1ccc(O)cc1.[Al]>>C=C(C)C(=O)NCC(=O)NCC(=O)Oc1ccc([N+](=O)[O-])cc1",
        "output": "108"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cl.N[C@@H]1C[C@H]1c1ccc(NC(=O)c2cccc(Cc3ccccc3)c2)cc1.O.O=C([O-])O.O=Cc1ccccc1.[BH4-].[Na+].[Na+]>>O=C(Nc1ccc([C@@H]2C[C@H]2NCc2ccccc2)cc1)c1cccc(Cc2ccccc2)c1",
        "output": "468"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CN1CCNCC1.O=C([O-])[O-].O=[N+]([O-])c1cccc(CBr)c1.[K+].[K+]>>CN1CCN(Cc2cccc([N+](=O)[O-])c2)CC1",
        "output": "248"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COc1cccc(C2CC(Cn3nnc(CC(=O)[O-])n3)c3nnc(C(F)(F)F)n3-c3ccc(Cl)cc32)c1OC.Cl.O.O=C([O-])[O-].[K+].[K+]>>COc1cccc(C2CC(Cn3nnc(CC(=O)O)n3)c3nnc(C(F)(F)F)n3-c3ccc(Cl)cc32)c1OC",
        "output": "151"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)OB(c2cc(N)cnc2Oc2ccc(F)cc2F)OC1(C)C.CCS(=O)(=O)Cl.ClCCl.O.c1ccncc1>>CCS(=O)(=O)Nc1cnc(Oc2ccc(F)cc2F)c(B2OC(C)(C)C(C)(C)O2)c1",
        "output": "812"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1ccc(-c2ccc(C(=O)CCC(=O)O)cc2)cc1.CCO.Cl.NO.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)c1ccc(-c2ccc(C(CCC(=O)O)=NO)cc2)cc1",
        "output": "212"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.CCOc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.COC(=O)Cc1cc(OC)ccc1O.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CCOc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCOc1ccc(OC)cc1CC(=O)O",
        "output": "928"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C1CN(C2COC2)CCN1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccc(Cl)cc21)=[N+](C)C.F[B-](F)(F)F.Nc1nn2cc(F)cnc2c1C(=O)Nc1cncc(F)c1N1CCC(C(=O)O)CC1.O>>Nc1nn2cc(F)cnc2c1C(=O)Nc1cncc(F)c1N1CCC(C(=O)N2CCN(C3COC3)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrC(Br)(Br)Br.CC#N.OCCc1c[nH]c2ccc(F)cc12.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Fc1ccc2[nH]cc(CCBr)c2c1",
        "output": "378"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.CSc1nccc(-c2cccnc2C)n1.O=C([O-])O.O=S([O-])OO.[K+].[Na+]>>Cc1ncccc1-c1ccnc(S(C)(=O)=O)n1",
        "output": "840"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.NC(=O)Nc1cn(-c2ccc(I)c(Cl)c2)nc1C(N)=O.O=C([O-])[O-].OB(O)c1cccc(O)c1.[Cs+].[Cs+]>>NC(=O)Nc1cn(-c2ccc(-c3cccc(O)c3)c(Cl)c2)nc1C(N)=O",
        "output": "855"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)/C=C/C(=O)c1nn(-c2cccc(OC(F)F)c2)ccc1=O.NNc1cccc(Cl)c1>>O=c1ccn(-c2cccc(OC(F)F)c2)nc1-c1ccnn1-c1cccc(Cl)c1",
        "output": "984"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.CN(CCF)c1cccc(O)c1.O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+]>>CN(CCF)c1ccc(C=O)c(O)c1",
        "output": "239"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)CBr.CCCCCC.CCc1ccc(-c2c(-c3ccccc3)oc3nccc(OCCCO)c23)cc1.CN(C)C=O.Cl.O>>CCc1ccc(-c2c(-c3ccccc3)oc3nccc(OCCCOCC(=O)OC(C)(C)C)c23)cc1",
        "output": "669"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4Nc4cccc(Br)n4)cc3)cc2)CC1.OB(O)c1c(Cl)cccc1Cl>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4Nc4cccc(-c5c(Cl)cccc5Cl)n4)cc3)cc2)CC1",
        "output": "869"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1cc2nccc(Oc3cccc(C(=O)Nc4cc(C)ccc4F)c3)c2s1.Cl.O.[Na+].[OH-]>>Cc1ccc(F)c(NC(=O)c2cccc(Oc3ccnc4cc(C(=O)O)sc34)c2)c1",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)CCCNC(=O)c1ccc(N2CCNCC2)nn1.O=C(Cl)c1cc(F)ccc1C(F)(F)F>>CC(C)CCCNC(=O)c1ccc(N2CCN(C(=O)c3cc(F)ccc3C(F)(F)F)CC2)nn1",
        "output": "201"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)CCCOc1ccccc1/C=C/I.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCCOc1ccccc1/C=C/I",
        "output": "225"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N1CCNCC1.CCc1cc(-c2cccc(C=O)n2)c(C)[nH]c1=O>>CCc1cc(-c2cccc(CN3CCN(C(C)=O)CC3)n2)c(C)[nH]c1=O",
        "output": "829"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.CCOc1cc(C=O)ccc1OC.O=[N+]([O-])O>>CCOc1cc(C=O)cc([N+](=O)[O-])c1OC",
        "output": "21"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COc1ccc2c(c1)CCC1(CCCCN1CCCC(CC#N)(c1ccccc1)c1ccccc1)C2.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>COc1ccc2c(c1)CCC1(CCCCN1CCCC(CCN)(c1ccccc1)c1ccccc1)C2",
        "output": "246"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCNCC1.COCCOC.C[C@H](NC(=O)OC(C)(C)C)c1cccc(Br)c1.ClCCl.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>C[C@H](NC(=O)OC(C)(C)C)c1cccc(N2CCN(C)CC2)c1",
        "output": "953"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc(Cl)ccc1N1CCNCC1.Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)O.F[P-](F)(F)(F)(F)F>>COc1cc(Cl)ccc1N1CCN(C(=O)Cn2nc(C(F)(F)F)c(Cl)c2C)CC1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)Cl.CO.COC(=O)CCCCCCCC(=O)O.O.[BH4-].[Na+]>>COC(=O)CCCCCCCCO",
        "output": "231"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO.CCOC(=O)Cc1cn2nc(C(F)(F)F)sc2n1.ClCCl.O.[BH4-].[Cl-].[NH4+].[NH4+].[Na+].[OH-]>>OCCc1cn2nc(C(F)(F)F)sc2n1",
        "output": "225"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(=O)CCl.CO.Nc1ncnn2c(CC3CNCCO3)cc(-c3ccc4cn(Cc5ccccc5)nc4c3)c12>>CN(C)C(=O)CN1CCOC(Cc2cc(-c3ccc4cn(Cc5ccccc5)nc4c3)c3c(N)ncnn23)C1",
        "output": "340"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(CC)CC.CCN(CC)CCC1CCNCC1.CCN=C=NCCCN(C)C.CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21.Cl.Cl.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CCN(CC)CCC1CCN(C(=O)Cc2ccc3c(c2)/C(=C\\CCN(C)C)c2ccccc2CO3)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](OCc1c(Cl)ccc(N)c1Cl)(c1ccccc1)c1ccccc1.ClCCl.O.O=C(Cl)CN1C(=O)c2ccccc2C1=O>>CC(C)(C)[Si](OCc1c(Cl)ccc(NC(=O)CN2C(=O)c3ccccc3C2=O)c1Cl)(c1ccccc1)c1ccccc1",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CCO.CS(C)=O.N#Cc1cc(F)c(NC2(C(N)=O)CCCC2)nc1Nc1cnc2ccccc2c1.OO.[Na+].[OH-]>>NC(=O)c1cc(F)c(NC2(C(N)=O)CCCC2)nc1Nc1cnc2ccccc2c1",
        "output": "677"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1cc2cc(NC(=O)CC)ccc2[nH]1.O.O=C([O-])[O-].[Cs+].[Cs+]>>CCC(=O)Nc1ccc2[nH]c(C(=O)O)cc2c1",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CCSc1nc(-c2ccc(OCCCl)c(OC)c2)cc2nccn12.[Na+].[OH-]>>CCSc1nc(-c2ccc(OCCN3CCOCC3)c(OC)c2)cc2nccn12",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.COCCOCCOCCBr.COc1cc([N+](=O)[O-])ccc1S.O=C([O-])[O-].[K+].[K+]>>COCCOCCOCCSc1ccc([N+](=O)[O-])cc1OC",
        "output": "124"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.COc1cc([N+](=O)[O-])c(O)cc1C.[Pd]>>COc1cc(N)c(O)cc1C",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCBr.CN(C)C=O.O[C@@H]1CCC[C@H](OCc2ccccc2)C1.[H-].[Na+]>>C=CCO[C@@H]1CCC[C@H](OCc2ccccc2)C1",
        "output": "120"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CO.O=[N+]([O-])c1cc(-c2cccnc2)ccc1O.[Pd]>>Nc1cc(-c2cccnc2)ccc1O",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1ccsn1.O=C(NC(=S)NCCCNc1ccsn1)c1ccccc1>>NC(=S)NCCCNc1ccsn1",
        "output": "80"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.ClCCl.O.O=[N+]([O-])c1cnc(OCC2CC2)c(Br)c1.[Cl-].[NH4+].[Zn]>>Nc1cnc(OCC2CC2)c(Br)c1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1ccc(CCNC(=O)c2ccc(-c3ccc(Cl)cc3)cc2)cc1.Cl.[Na+].[OH-]>>O=C(O)c1ccc(CCNC(=O)c2ccc(-c3ccc(Cl)cc3)cc2)cc1",
        "output": "5"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CS(C)=O.Cc1nn(-c2ccc(C#N)c(F)c2)c2c1C(=O)CC(C)(C)C2.N[C@H]1CCC[C@@H]1OCc1ccccc1>>Cc1nn(-c2ccc(C#N)c(N[C@H]3CCC[C@@H]3OCc3ccccc3)c2)c2c1C(=O)CC(C)(C)C2",
        "output": "572"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CO.O=C(O)Cc1c[nH]c2ccc(O)cc12>>COC(=O)Cc1c[nH]c2ccc(O)cc12",
        "output": "195"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc(OC)c(N(C(=O)OC(C)(C)C)S(C)(=O)=O)c1.[Li+].[OH-]>>COc1ccc(C(=O)O)cc1N(C(=O)OC(C)(C)C)S(C)(=O)=O",
        "output": "222"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)N1CCN(S(C)(=O)=O)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1c(Cl)c2cc(Oc3ccc(C(F)(F)F)cc3)ccc2n1-c1ccc(OC(C)C)cc1.Cl.ClCCl.O.[Na+].[OH-]>>CC(C)Oc1ccc(-n2c(C(=O)O)c(Cl)c3cc(Oc4ccc(C(F)(F)F)cc4)ccc32)cc1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrP(Br)Br.Cc1ccccc1.O.O=S1(=O)CCc2cc(CO)ccc21>>O=S1(=O)CCc2cc(CBr)ccc21",
        "output": "300"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COC[C@H](C)N.ClCCl.O=Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)nc1.[Na+]>>COC[C@H](C)NCc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)nc1",
        "output": "441"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.COc1ccc(CC(=O)NCc2ccccc2N(C)S(C)(=O)=O)cc1OC.CSC>>COc1ccc(CCNCc2ccccc2N(C)S(C)(=O)=O)cc1OC",
        "output": "533"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)CCCCCCNC(=O)C(CO)NS(=O)(=O)c1ccc(Cl)cc1.CS(=O)(=O)Cl>>COC(=O)CCCCCCNC(=O)C(COS(C)(=O)=O)NS(=O)(=O)c1ccc(Cl)cc1",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCCCCCC(=O)O.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NCCc1ccccc1.On1nnc2ccccc21>>CC(C)(C)OC(=O)NCCCCCC(=O)NCCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)c1ccc(CCF)c(S(=O)(=O)N2CCCC(OCc3ccccc3)CC2)c1.Cl.O>>O=C(O)c1ccc(CCF)c(S(=O)(=O)N2CCCC(OCc3ccccc3)CC2)c1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.Nc1ccc(C=O)cc1[N+](=O)[O-].O.O=CO>>O=CNc1ccc(C=O)cc1[N+](=O)[O-]",
        "output": "27"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)=O.CCOC(=O)c1c(C)nc(NN)c2nnn(CC)c12>>CCOC(=O)c1c(C)nc(NN=C(C)C)c2nnn(CC)c12",
        "output": "285"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.CN1CCC[C@H]1CO.COC(=O)C(O)(c1cccs1)c1cccs1.Cc1ccccc1.[Na]>>CN1CCC[C@H]1COC(=O)C(O)(c1cccs1)c1cccs1",
        "output": "289"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cccc2cc(OC(C)C)ccc12.O=C1CCC(=O)N1Br>>CC(C)Oc1ccc2c(CBr)cccc2c1",
        "output": "29"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CO.COC(=O)c1cc2c(N)cccc2s1.O.O.[Li+].[OH-]>>Nc1cccc2sc(C(=O)O)cc12",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=O.CC1CC(Oc2ccc([N+](=O)[O-])cc2Cl)CCN1C(=O)OC(C)(C)C.O=C([O-])[O-].O=CO.[K+].[K+]>>CC1CC(Oc2ccc([N+](=O)[O-])cc2Cl)CCN1C",
        "output": "881"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(C(=O)O)cc1.O.O=S(=O)(O)O.OB(O)O.Oc1ccc(O)cc1>>COc1ccc(C(=O)Oc2ccc(O)cc2)cc1",
        "output": "355"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC=O.CO.COc1ccc(-c2[nH]c(-c3ccc(N)cc3)nc2C(=O)Nc2nccs2)cc1.O=C([O-])O.O=S(=O)(O)O.[BH4-].[Na+].[Na+]>>CCNc1ccc(-c2nc(C(=O)Nc3nccs3)c(-c3ccc(OC)cc3)[nH]2)cc1",
        "output": "336"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CCOCC.CO.C[Si](C)(C)C=[N+]=[N-].Cc1ccccc1.O=C(O)c1cc([N+](=O)[O-])c(F)cc1Cl>>COC(=O)c1cc([N+](=O)[O-])c(F)cc1Cl",
        "output": "195"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cc(NC(=O)Nc2ccccc2)ccc1N.O=S(=O)(Cl)c1cccc(-c2ccc(F)cc2)c1>>Cc1cc(NC(=O)Nc2ccccc2)ccc1NS(=O)(=O)c1cccc(-c2ccc(F)cc2)c1",
        "output": "68"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)[C@@H]1C[C@H]1C(=O)OCC.[Na+].[OH-]>>CCOC(=O)[C@@H]1C[C@H]1C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCc1cccc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(S(=O)(=O)C4CC4)cc3)s2)c1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.O.[F-]>>O=C(Nc1ncc(Oc2cccc(CO)c2)s1)C(OC1CCOCC1)c1ccc(S(=O)(=O)C2CC2)cc1",
        "output": "708"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)c1cc(COCCc2ccccc2)on1.O.[K+].[OH-]>>O=C(O)c1cc(COCCc2ccccc2)on1",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Nc1ccc(Br)cc1.CI.CN(C)C=O.O=C([O-])O.[H-].[Na+].[Na+]>>CC(=O)N(C)c1ccc(Br)cc1",
        "output": "237"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=O.O.O=CO.[Na+].[OH-].c1cncc(C2NC3CCC2CC3)c1>>CN1C2CCC(CC2)C1c1cccnc1",
        "output": "217"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1c(SCCCCl)ccnc1CSc1ccncc1.Sc1ccncc1.[Na+].[OH-]>>Cc1c(SCCCSc2ccncc2)ccnc1CSc1ccncc1",
        "output": "460"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1ccc2nc(Cc3ccccc3)n(Cc3ccc(Cl)cc3Cl)c2c1.Cl.[Na+].[OH-]>>O=C(O)c1ccc2nc(Cc3ccccc3)n(Cc3ccc(Cl)cc3Cl)c2c1",
        "output": "5"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1=C(CCCCCCl)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C1=O.CCC(C)=O.CCOC(C)=O.[I-].[Na+]>>CC1=C(CCCCCI)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C1=O",
        "output": "97"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC2(CC1)CNC2.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CCOC(C)=O.CS(=O)(=O)c1cnc(Cl)cn1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>CC(C)(C)OC(=O)N1CCC2(CC1)CN(c1cnc(S(C)(=O)=O)cn1)C2",
        "output": "505"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.Cc1ccc(-c2noc(CNCC(C)C)n2)cc1.Cc1ccc(OCC(=O)Cl)cc1>>Cc1ccc(OCC(=O)N(Cc2nc(-c3ccc(C)cc3)no2)CC(C)C)cc1",
        "output": "125"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNC1.O=C(O)c1ccnc(Cl)c1>>O=C(O)c1ccnc(N2CCCC2)c1",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(N)c1nnc(-c2ccccc2)o1.CC1(COc2cc(C(=O)O)ncc2C2CC2)COC1.CCN(C(C)C)C(C)C.COc1nc(OC)nc([N+]2(C)CCOCC2)n1.ClCCl.[Cl-]>>CC1(COc2cc(C(=O)NC(C)(C)c3nnc(-c4ccccc4)o3)ncc2C2CC2)COC1",
        "output": "137"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.ClCCBr.O.O=c1[nH]c2ccccc2n1CCOC1CCCCO1>>O=c1n(CCCl)c2ccccc2n1CCOC1CCCCO1",
        "output": "495"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cccc(C(=CCBr)c2ccccc2C)c1.Cc1ccccc1.OCCO.[Li]CCCC>>COc1cccc(C(=CCOCCO)c2ccccc2C)c1",
        "output": "120"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.CCN(C(C)C)C(C)C.CCc1cccc(CC)c1-c1cc2c(C(O)CC(C)C)cn(-c3ccc(C(C)C)cc3)c2cn1.CN(C)c1ccncc1.ClCCl>>CCc1cccc(CC)c1-c1cc2c(C(CC(C)C)OC(C)=O)cn(-c3ccc(C(C)C)cc3)c2cn1",
        "output": "254"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.Nc1ccc2nc(C(=O)c3ccccc3)cn2c1>>CC(=O)Nc1ccc2nc(C(=O)c3ccccc3)cn2c1",
        "output": "724"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cc1onc(-c2ccccc2)c1COc1ccc([N+](=O)[O-])cn1.[Cl-].[NH4+].[Zn]>>Cc1onc(-c2ccccc2)c1COc1ccc(N)cn1",
        "output": "269"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.O=C(Nc1c(Cl)cc(O)cc1[N+](=O)[O-])C1CCOCC1.[H][H].[Ni]>>Nc1cc(O)cc(Cl)c1NC(=O)C1CCOCC1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CI.Cc1noc(-c2ccc(-c3ccc(C4(C(=O)O)CC4)cc3)cc2)c1CCC(=O)Nc1ccccc1>>Cc1noc(-c2ccc(-c3ccc(C4(C(=O)O)CC4)cc3)cc2)c1CCC(=O)N(C)c1ccccc1",
        "output": "237"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=C1[C@H](Cc2c(Cl)cc(O)cc2Cl)CCN1C1CCOCC1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>O=C1[C@H](Cc2c(Cl)cc(OS(=O)(=O)C(F)(F)F)cc2Cl)CCN1C1CCOCC1",
        "output": "731"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)Cc1cccc(Cl)c1OCc1ccccc1.[C].[Pd]>>COC(=O)Cc1cccc(Cl)c1O",
        "output": "23"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)c1nnc(-c2nccnc2N)o1.O=C1CCC(=O)N1Br>>CC(C)(C)c1nnc(-c2nc(Br)cnc2N)o1",
        "output": "665"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCO.CCOC(=O)CC(=O)c1ccc2c(cnn2CC)c1.Cc1ccc(S(=O)(=O)O)cc1.Cc1cnoc1-c1cn[nH]c1N>>CCn1ncc2cc(-c3cc(=O)n4ncc(-c5oncc5C)c4[nH]3)ccc21",
        "output": "513"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.Cc1ccc(S(=O)(=O)OCCCCc2c[nH]c3ccc(C#N)cc23)cc1.O=C([O-])[O-].O=c1c2cccnc2ccn1-c1ccc(N2CCNCC2)cc1.[I-].[K+].[K+].[K+]>>N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(-n5ccc6ncccc6c5=O)cc4)CC3)c2c1",
        "output": "429"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.CC(=O)Oc1ccc2ncccc2c1.ClC(Cl)(Cl)Cl.c1ccncc1>>CC(=O)Oc1ccc2ncc(Br)cc2c1",
        "output": "292"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCCCC1CCO.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)N1CCCCC1CCOS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCOC(C)=O.Cc1ccsc1-c1cn(CCCO)c(=O)[nH]c1=O>>Cc1ccsc1-c1cn(CCC=O)c(=O)[nH]c1=O",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1c(N2CCCCC2)nc2ccc(Cl)cc2c1Cc1ccccc1Cl.[Na+].[OH-]>>O=C(O)c1c(N2CCCCC2)nc2ccc(Cl)cc2c1Cc1ccccc1Cl",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.O=C1CC(c2ccccc2)Oc2cc(O)ccc21.OCCn1ccnc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C1CC(c2ccccc2)Oc2cc(OCCn3ccnc3)ccc21",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOCCO.COc1cc2ncc(C#N)c(Cl)c2cc1OC.Cc1cc(O)ccc1N.Cl.c1ccncc1>>COc1cc2ncc(C#N)c(Nc3ccc(O)cc3C)c2cc1OC",
        "output": "115"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCC(CC)(O[Si](C)(C)C)C(F)(F)C=O.CCO.[BH4-].[Na+]>>CCC(CC)(O[Si](C)(C)C)C(F)(F)CO",
        "output": "223"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cn1cc(-c2ccnc(-n3ncc4c5c(sc4c3=O)CCCC5)c2C=O)cc(Nc2ccccn2)c1=O.[BH4-].[Na+]>>Cn1cc(-c2ccnc(-n3ncc4c5c(sc4c3=O)CCCC5)c2CO)cc(Nc2ccccn2)c1=O",
        "output": "476"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1.O=C(O)Cn1nnc2ccccc21>>O=C(Cn1nnc2ccccc21)N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1",
        "output": "133"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCC.CCOC(C)=O.CO.COC(=O)C(C)c1ccc(S(C)(=O)=O)c(Cl)c1.Cl.O.[Na+].[OH-]>>CC(C(=O)O)c1ccc(S(C)(=O)=O)c(Cl)c1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C(N)=O)C(F)(F)F.O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3>>CC(C)(C#N)C(F)(F)F",
        "output": "172"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.O=C(O)c1cnoc1-c1ccccc1>>O=C(c1cnoc1-c1ccccc1)N1CCCC1",
        "output": "975"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)COc1ccc2c(c1)S(=O)(=O)N=C(c1c(O)c3ccccc3n(CCC(C)C)c1=O)N2.Cl.O.[Na+].[OH-]>>CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(OCC(=O)O)ccc3N2)c(O)c2ccccc21",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(c1cc(NC(=O)Oc2ccccc2)no1)C(F)(F)F.CCOc1cc2c(Sc3cccc(N)c3)ncnc2cc1OC.CN(C)c1ccncc1>>CCOc1cc2c(Sc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)ncnc2cc1OC",
        "output": "948"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(NCCCN)c2c1>>CC(=O)NCCCNc1cc(N2CCS(=O)(=O)c3ccccc3C2)nc2ccc(C)cc12",
        "output": "339"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(Br)c(Oc2ccc([N+](=O)[O-])cc2)c(Br)c1.Cl.ClCCl>>O=[N+]([O-])c1ccc(Oc2c(Br)cc(O)cc2Br)cc1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ncccc1CO.O=S(=O)(Nc1ncc(Cl)nc1Cl)c1cccc(Cl)c1Cl>>Cc1ncccc1COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl",
        "output": "209"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)NCc1ccc2c(c1)N(C1CCNCC1)CC2.COc1ccc(CCBr)cc1>>COc1ccc(CCN2CCC(N3CCc4ccc(CNC(C)=O)cc43)CC2)cc1",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=[N+]=[N-].CCCCCCCCC(O)/C=C/C=C/c1ccccc1CCCCC(=O)O.ClCCl>>CCCCCCCCC(O)/C=C/C=C/c1ccccc1CCCCC(=O)OC",
        "output": "60"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)Cc1ccc(C(=O)c2ccc(CC(C)C)cc2C(C)Cl)c(C(C)Cl)c1.CC(C)Cc1ccccc1.CC(Cl)C(=O)Cl.COc1ccc2ccccc2c1>>COc1ccc2cc(C(=O)C(C)Cl)ccc2c1",
        "output": "31"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(C)(C)c1cc(S(=O)(=O)/C=C/C#N)ccc1OCC(=O)O.CCN=C=NCCCN(C)C.Cl.NCc1ccc(F)cc1.On1nnc2ccccc21>>CC(C)(C)c1cc(S(=O)(=O)/C=C/C#N)ccc1OCC(=O)NCc1ccc(F)cc1",
        "output": "599"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCN=C=S.ClCCl.NC1CCN(C(=O)c2ccc(-n3ccnc3)cc2)CC1>>CCCCNC(=S)NC1CCN(C(=O)c2ccc(-n3ccnc3)cc2)CC1",
        "output": "79"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1ccc(OC)c(NC(=O)CCl)c1.ClCCl.O>>O=C(CCl)Nc1cc(O)ccc1O",
        "output": "20"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CNc1ccnc(N)c1.COc1cc(OC)cc(C(=O)CBr)c1>>CNc1ccn2cc(-c3cc(OC)cc(OC)c3)nc2c1",
        "output": "508"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)C1=CN(C)C=C(C(=O)OC)C1C=C(C)C.Cl.[Li+].[OH-]>>COC(=O)C1=CN(C)C=C(C(=O)O)C1C=C(C)C",
        "output": "58"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1ccc(C#Cc2ccc(C3(OC(C)C)CC3)c(CC)c2)cc1.[Na+].[OH-]>>CCc1cc(C#Cc2ccc(C(=O)O)cc2)ccc1C1(OC(C)C)CC1",
        "output": "5"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)c1nc(C(F)(F)F)c(C(F)(F)F)nc1N.Cl.O.[Na+].[OH-]>>Nc1nc(C(F)(F)F)c(C(F)(F)F)nc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)c1ccnc(CO)c1.ClCCl.O=[Se]=O>>CC(C)(C)c1ccnc(C=O)c1",
        "output": "263"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C.N>>CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(N)=O",
        "output": "432"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NCCCCn1cnc2c(N)nc3ccccc3c21.O=C(Cl)c1cccc2cccnc12>>Nc1nc2ccccc2c2c1ncn2CCCCNC(=O)c1cccc2cccnc12",
        "output": "353"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c(F)c1.OCCN1CCOCC1.[Cs+].[Cs+]>>O=[N+]([O-])c1ccc(OCCN2CCOCC2)c(F)c1",
        "output": "485"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(=O)CC(C)N.ClCCCl.O=C([O-])O.O=Cc1ccccc1.[Na+].[Na+]>>CCOC(=O)CC(C)NCc1ccccc1",
        "output": "468"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1c(Nc2ccc(I)cc2F)c(N)c2n(c1=O)CCS2.O=S(=O)(Cl)C1CC(OCc2ccccc2)C1.c1ccncc1>>Cc1c(Nc2ccc(I)cc2F)c(NS(=O)(=O)C2CC(OCc3ccccc3)C2)c2n(c1=O)CCS2",
        "output": "812"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOc1ccc(-c2ccc(CCCc3nn(-c4ccc(C(F)(F)F)cc4)c(=O)n3-c3ccccc3F)cc2)cc1CC(=O)OC.CO.O.[Li+].[OH-]>>CCOc1ccc(-c2ccc(CCCc3nn(-c4ccc(C(F)(F)F)cc4)c(=O)n3-c3ccccc3F)cc2)cc1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OCCC(C)(O)c1ccccc1-c1ccccc1.CCO.O.[Na+].[OH-]>>CC(O)(CCO)c1ccccc1-c1ccccc1",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.Cn1ncc(C(=O)O)c1C(=O)Nc1ccc2nc(N3CCCC3)nn2c1>>Cn1ncc(C(=O)N2CCOCC2)c1C(=O)Nc1ccc2nc(N3CCCC3)nn2c1",
        "output": "733"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1O[C@@H]1CC[C@H](NC(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1O[C@@H]1CC[C@H](N)CC1",
        "output": "538"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CS(C)=O.Cl[Pd]Cl.O.O=C(N=S1(=O)CCN(c2ccc(Br)cc2)CC1)C(F)(F)F.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc(N3CCS(=O)(=NC(=O)C(F)(F)F)CC3)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc2c(Cl)nc(Nc3cc(C)[nH]n3)cc2c1.N#Cc1ccc(B(O)O)cc1>>COc1ccc2c(-c3ccc(C#N)cc3)nc(Nc3cc(C)[nH]n3)cc2c1",
        "output": "865"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCCBr.CCCNC(=O)Nc1ccc(Oc2ncnc3cc(O)c(OC)cc23)cc1Cl.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCCNC(=O)Nc1ccc(Oc2ncnc3cc(OCCBr)c(OC)cc23)cc1Cl",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)Cc1ccc(Cc2cc(-c3cccc(Cl)c3)nc(C(F)(F)F)c2)cc1>>OCCc1ccc(Cc2cc(-c3cccc(Cl)c3)nc(C(F)(F)F)c2)cc1",
        "output": "343"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCC(CN)(c2nc(-c3ccccc3)cs2)CC1.O=C(O)c1cccc(-c2noc(C(F)(F)F)n2)c1>>CN1CCC(CNC(=O)c2cccc(-c3noc(C(F)(F)F)n3)c2)(c2nc(-c3ccccc3)cs2)CC1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COc1cc(NC(=O)OCCN(C)[C@@H]2CC[C@@H](OC(=O)C(O)(c3cccs3)c3cccs3)CC2)c(Cl)cc1CO[Si](C)(C)C(C)(C)C.Cl.O=C([O-])O.[Na+]>>COc1cc(NC(=O)OCCN(C)[C@@H]2CC[C@@H](OC(=O)C(O)(c3cccs3)c3cccs3)CC2)c(Cl)cc1CO",
        "output": "708"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3ccc(C(=O)O)cc23)ccn1.Cl.F[P-](F)(F)(F)(F)F.NC1CCCC(CO)(Oc2cccc(F)c2)C1>>Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3ccc(C(=O)NC4CCCC(CO)(Oc5cccc(F)c5)C4)cc23)ccn1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#C[C@@H](CC(=O)OC)c1ccc(O)cc1.Cc1cc(OCCCS(C)(=O)=O)ccc1-c1csc2ccc(CO)cc12.O=C(/N=N/C(=O)OCc1ccccc1)OCc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC#C[C@@H](CC(=O)OC)c1ccc(OCc2ccc3scc(-c4ccc(OCCCS(C)(=O)=O)cc4C)c3c2)cc1",
        "output": "347"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Cc1nc(-c2ccc(C(F)(F)F)cc2)ccc1CCl.O.Oc1ccc(CCCCn2ccnn2)cc1.[H-].[Na+]>>Cc1nc(-c2ccc(C(F)(F)F)cc2)ccc1COc1ccc(CCCCn2ccnn2)cc1",
        "output": "678"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOP(=O)(OCC)On1nnc2ccccc2c1=O.CN1CCNCC1.COC(=O)CCC[C@H](NC(=O)c1ccc(F)cc1)C(=O)O.O=P([O-])(O)O.[K+].c1c[nH]cn1>>COC(=O)CCC[C@H](NC(=O)c1ccc(F)cc1)C(=O)N1CCN(C)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CN(C(C)(C)C#N)C3)ccc1-2.CS(C)=O.O.O=C([O-])[O-].OO.[K+].[K+]>>CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CN(C(C)(C)C(N)=O)C3)ccc1-2",
        "output": "632"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CCOC(=O)c1cn(-c2ccc3c(c2)sc(=O)n3C)c(=O)n(C2CCc3c(OC)cccc32)c1=O.Cl>>COc1cccc2c1CCC2n1c(=O)c(C(=O)O)cn(-c2ccc3c(c2)sc(=O)n3C)c1=O",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.COc1ccc(CN2CC(COS(C)(=O)=O)CC2=O)c(OC)c1.O.[I-].[N-]=[N+]=[N-].[Na+].[Na+]>>COc1ccc(CN2CC(CN=[N+]=[N-])CC2=O)c(OC)c1",
        "output": "322"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)c(C(F)(F)F)c2)CC1.CCOC(C)=O.Cl>>O=C(Cc1ccc(OC2CCNCC2)cc1C(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(CCC(=O)O)cc1F.Cl.c1ccncc1>>O=C(O)CCc1ccc(O)c(F)c1",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)C(Oc1nc(OC)cc(OC)n1)C(C)(OCc1ccccc1)c1ccccc1.[Na+].[OH-]>>COc1cc(OC)nc(OC(C(=O)O)C(C)(OCc2ccccc2)c2ccccc2)n1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClC(Cl)(Cl)Cl.O=C1NCCN1c1ccccc1.O=S(=O)(O)Cl>>O=C1NCCN1c1ccc(S(=O)(=O)Cl)cc1",
        "output": "182"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NC(C)(C)C(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(=O)[C@@H](N)COCc1ccccc1.Cl.ClCCl.On1nnc2cccnc21>>CCOC(=O)[C@H](COCc1ccccc1)NC(=O)C(C)(C)NC(=O)OC(C)(C)C",
        "output": "107"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.O=[Mn]=O.OCc1cnccc1Oc1ccccc1>>O=Cc1cnccc1Oc1ccccc1",
        "output": "520"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Br.CC(=O)O.COc1cc(CCNC(=O)C(=CO)c2ccc(C)cc2)ccc1OCc1ccccc1>>COc1cc(CCNC(=O)C(=CO)c2ccc(C)cc2)ccc1O",
        "output": "23"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCCCN1CC(O)C2(CC2)C1>>CS(=O)(=O)OCCCN1CC(O)C2(CC2)C1",
        "output": "0"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1ccc2c(c1)[nH]c1c(C(=O)O)cc(C)c(Br)c12.CCOC(C)=O.ClCCCl.ClCCl.On1nnc2ccccc21.[NH4+].[OH-]>>CCOC(=O)c1ccc2c(c1)[nH]c1c(C(N)=O)cc(C)c(Br)c12",
        "output": "704"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)C(=O)Nc1ccc(C(F)(F)F)cc1[N+](=O)[O-].CCO.[H][H].[Pd]>>CC(C)C(=O)Nc1ccc(C(F)(F)F)cc1N",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Nc1ccnc(Cl)c1.O.[H-].[Na+]>>COc1cc(N)ccn1",
        "output": "433"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccc2c(c1)CCNCC2>>O=C(N1CCc2ccccc2CC1)C(F)(F)F",
        "output": "397"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCl.O=[Cr](=O)([O-])Cl.OCC1CCN(c2nc(Cl)nc3scc(-c4ccccc4)c23)CC1.c1cc[nH+]cc1>>O=CC1CCN(c2nc(Cl)nc3scc(-c4ccccc4)c23)CC1",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.ClCCl.O.O=Cc1c(Cl)cccc1-n1ccc2cc(C3CC3)cc(F)c2c1=O.[BH4-].[Na+]>>O=c1c2c(F)cc(C3CC3)cc2ccn1-c1cccc(Cl)c1CO",
        "output": "356"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrP(Br)Br.COc1cc(Cl)cc(CO)c1Cl.Cc1ccccc1>>COc1cc(Cl)cc(CBr)c1Cl",
        "output": "300"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(CO)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CCC4CCCC[C@]4(C)[C@H]3CC[C@]12C.O.O=C(O)CCl>>CC(CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CCC4CCCC[C@]4(C)[C@H]3CC[C@]12C)COC(=O)CCl",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(F)cc2F)c(OC)c1.CS(C)=O.O=C([O-])[O-].Oc1cc(-c2ccccc2F)c(Cl)cc1I.[K+].[K+]>>COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(Oc3cc(-c4ccccc4F)c(Cl)cc3I)cc2F)c(OC)c1",
        "output": "564"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CC(=O)c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1.ClCCl.O>>CC(C)(C)c1cc(C(=O)CBr)cc(C(C)(C)C)c1O",
        "output": "173"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCCCNc1c([N+](=O)[O-])cnc2ccccc12.[Pt]>>CC(C)(C)OC(=O)NCCCNc1c(N)cnc2ccccc12",
        "output": "269"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)c1ccc(-c2nc(NCC(c3ccccc3)c3ccc[nH]3)c3ccccc3n2)cc1.CO.CS(=O)(=O)Nc1ccc(B(O)O)cc1.ClCCl.Clc1nc(NCC(c2ccccc2)N2CCOCC2)c2ccccc2n1>>CS(=O)(=O)Nc1ccc(-c2nc(NCC(c3ccccc3)N3CCOCC3)c3ccccc3n2)cc1",
        "output": "874"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COc1ccc(Br)nc1C(=O)NCc1ccc(Cl)cc1.[Cl-].[Li+]>>O=C(NCc1ccc(Cl)cc1)c1nc(Br)ccc1O",
        "output": "424"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.COC(=O)c1ccc(N)cc1.ClCCl>>COC(=O)c1ccc(NC(=O)CNC(=O)OC(C)(C)C)cc1",
        "output": "710"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CNCC(OC)OC.COc1c(C=O)ccc2c1OCO2.Cl.[BH3-]C#N.[Na+].[Na+].[OH-]>>COc1c(CO)ccc2c1OCO2",
        "output": "356"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C(O)c1ccc(F)cc1F.O=S(=O)(Cl)Cl>>COC(=O)c1ccc(F)cc1F",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(C)=O.N#Cc1cccc(Oc2ccc([N+](=O)[O-])c(Oc3cccc(C#N)c3)n2)c1.[H][H].[Pd]>>N#Cc1cccc(Oc2ccc(N)c(Oc3cccc(C#N)c3)n2)c1",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CCc1ccccc1)C(=O)O.CCN(CC)CC.CNOC.Cl.ClCCCl.ClCCl.On1nnc2ccccc21>>CON(C)C(=O)[C@H](CCc1ccccc1)NC(=O)OC(C)(C)C",
        "output": "54"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.FC(F)(F)c1ccc(-c2cc(Cl)nc(Cl)n2)cc1.Nc1cccc2c1CC(O)CC2>>OC1CCc2cccc(Nc3cc(-c4ccc(C(F)(F)F)cc4)nc(Cl)n3)c2C1",
        "output": "161"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=C([O-])O.O=Cc1cc(Cl)cc(Cl)c1.OCCO.[Na+]>>Clc1cc(Cl)cc(C2OCCO2)c1",
        "output": "117"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "N.O=C(O)Cc1ccc2c(c1)OCCO2.O=S(Cl)Cl>>NC(=O)Cc1ccc2c(c1)OCCO2",
        "output": "313"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCCCCCCCCBr.CCOC(C)=O.CN1CCCC1=O.COCCOC.Cc1cccc(OCCCCCCCCBr)c1.O=C([O-])[O-].Oc1cccc(F)c1.[K+].[K+]>>Fc1cccc(OCCCCCCCCBr)c1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.O=C1Nc2ccccc2/C1=C(/Nc1cccc([N+](=O)[O-])c1)c1ccccc1.[H][H].[Pd]>>Nc1cccc(N/C(=C2\\C(=O)Nc3ccccc32)c2ccccc2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cl.ClCc1cccnc1.O=S(=O)(c1cc(O)c2ccccc2c1)N1CC2CCC(CC2)C1.[H-].[Na+]>>O=S(=O)(c1cc(OCc2cccnc2)c2ccccc2c1)N1CC2CCC(CC2)C1",
        "output": "678"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2cc(C=O)nc(C(F)(F)F)n2)CC1.CNC.N#CCNC(=O)CNc1ccc(C(=O)O)cc1>>CN(C)Cc1cc(OC2CCN(C(=O)OC(C)(C)C)CC2)nc(C(F)(F)F)n1",
        "output": "829"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=[N+]([O-])c1cc(C(F)(F)F)cnc1O.[H][H].[Pd]>>Nc1cc(C(F)(F)F)cnc1O",
        "output": "269"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN1CCNCC1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cc([N+](=O)[O-])cc(C(F)(F)F)c1>>CCN1CCN(C(=O)c2cc([N+](=O)[O-])cc(C(F)(F)F)c2)CC1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(CO)cc1N.O=C(Cl)CC12CC3CC(CC(C3)C1)C2>>Cc1ccc(CO)cc1NC(=O)CC12CC3CC(CC(C3)C1)C2",
        "output": "9"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CN(C)C=O.COc1cc2c(Cl)ncnc2cc1OCCCN1CCOCC1.C[Si](C)(C)[N-][Si](C)(C)C.Nc1c(Cl)cc(C#Cc2ccccn2)c2c1OCO2.[Cl-].[NH4+].[Na+]>>COc1cc2c(Nc3c(Cl)cc(C#Cc4ccccn4)c4c3OCO4)ncnc2cc1OCCCN1CCOCC1",
        "output": "161"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)OCc1cccc(CN2C(=O)c3ccccc3C2=O)c1.CCO.ClCCl.NN.O>>CC(C)(C)[Si](C)(C)OCc1cccc(CN)c1",
        "output": "418"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CC(C)(C)OC(=O)N1CCc2ccc(S(=O)(=O)c3cccc(O)c3)cc2CC1.CN(C)C=O.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCc2ccc(S(=O)(=O)c3cccc(OCc4ccccc4)c3)cc2CC1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc2c(NC(C)C)ncnc2cc1O.CSCCCCO.ClCCl.O.O=C(/N=N/C(=O)N1CCCCC1)N1CCCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc2c(NC(C)C)ncnc2cc1OCCCCSC",
        "output": "478"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCNCC1.COC(OC)OC.ClCCCl.O=Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1.[Na+]>>CC(C)(C)OC(=O)N1CCN(Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1",
        "output": "792"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCO.O=C(NCC1CCN(Cc2ccccc2)CC1)c1c2n(c3ccccc13)CCCO2.O=C(O)C(=O)O>>O=C(NCC1CCNCC1)c1c2n(c3ccccc13)CCCO2",
        "output": "84"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)CCO.Cl.Cl.Clc1ccc(Cl)nc1.O=C([O-])[O-].OC[C@@H]1CC[C@H]2CNCCN2C1.[Na+].[Na+]>>OC[C@@H]1CC[C@H]2CN(c3ccc(Cl)cn3)CCN2C1",
        "output": "220"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.COCCOC.Nc1cc(C(F)(F)F)ccc1N1CCOCC1>>CC(=O)Nc1cc(C(F)(F)F)ccc1N1CCOCC1",
        "output": "6"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOc1ccc(OCc2ccccc2)cc1C#N.CO.[Pd]>>CCOc1ccc(O)cc1C#N",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOc1cc(C=O)cc(OCC)c1-c1ccc(F)cc1.COC(=O)[C@H]1CC[C@@H](C2=NOC3(CNC3)C2)CC1.Cl>>CCOc1cc(CN2CC3(CC([C@@H]4CC[C@H](C(=O)OC)CC4)=NO3)C2)cc(OCC)c1-c1ccc(F)cc1",
        "output": "567"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CN(C2CCOCC2)CCN1.CN(C)C=O.Cl.Cl.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[K+].[K+]>>O=[N+]([O-])c1ccc(N2CCN(C3CCOCC3)CC2)cc1",
        "output": "26"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCC[C@@H](O)c1cccc(O)c1.CN(C)C=O.Cc1ccc(S(=O)(=O)OCC2CCCSC2)cc1.O=C([O-])[O-].Oc1ccccc1.[K+].[K+]>>CC(C)(C)OC(=O)NCC[C@@H](O)c1cccc(OCC2CCCSC2)c1",
        "output": "438"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCCCOc1ccc(Oc2ccccc2)cc1.CCCO[C@@H](Cc1ccc(O)cc1)C(=O)OCC>>CCCO[C@@H](Cc1ccc(OCCCOc2ccc(Oc3ccccc3)cc2)cc1)C(=O)OCC",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCBr.CCC(C)=O.CCOC(=O)CCc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>C=CCOc1ccc(CCC(=O)OCC)cc1",
        "output": "77"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCOC(C)=O.CO.Nc1cncc(Cl)n1.[H-].[Na+]>>COc1cncc(N)n1",
        "output": "209"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.O.O=P(Cl)(Cl)Cl.Oc1cc(C(F)(F)F)nc(C2CC2)n1>>FC(F)(F)c1cc(Cl)nc(C2CC2)n1",
        "output": "25"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(Br)cc1[N+](=O)[O-].Nc1ccc(Sc2ccccc2)c2c1C(=O)c1ccccc1C2=O.O=C([O-])[O-].O=[N+]([O-])c1ccccc1.[Na+].[Na+]>>Cc1ccc(Nc2ccc(Sc3ccccc3)c3c2C(=O)c2ccccc2C3=O)cc1[N+](=O)[O-]",
        "output": "405"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN.CCN(C(C)C)C(C)C.CN(C)C=O.FC1(F)CCN(c2nc(Cl)nc3c2nnn3Cc2ccccc2Cl)C1>>CCNc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3Cl)c2n1",
        "output": "578"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Nc1cc(C(=O)O)ccc1C(=O)O.O=S(=O)(O)O>>COC(=O)c1ccc(C(=O)O)c(N)c1",
        "output": "33"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1cc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)nc1OCc1ccccc1.Cl.O.[Na+].[OH-]>>O=C(O)c1cc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)nc1OCc1ccccc1",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(F)ccc1Br.Cc1cc(F)ccc1O.Cc1ccc(F)cc1Br>>Cc1cc(F)ccc1Oc1cc(F)ccc1C",
        "output": "238"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.ClCCl.FC(F)(F)c1cnc2[nH]ccc2c1.O=S(=O)(Cl)c1ccccc1.[Br-].[Na+].[OH-]>>O=S(=O)(c1ccccc1)n1ccc2cc(C(F)(F)F)cnc21",
        "output": "354"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCO.CN.Cl.Fc1ccc2ncnc(Nc3cccc(Br)c3)c2n1>>CNc1ccc2ncnc(Nc3cccc(Br)c3)c2n1",
        "output": "810"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.COCCBr.CS(=O)(=O)c1cccc(Nc2cc(-c3ccccc3O)ncn2)c1.O=C([O-])[O-].[K+].[K+]>>COCCOc1ccccc1-c1cc(Nc2cccc(S(C)(=O)=O)c2)ncn1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C(=O)O.CNC>>CCOC(=O)C=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C(=O)N(C)C",
        "output": "517"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CNC(C(=O)O)c1ccccc1.CO.O=S(Cl)Cl>>CNC(C(=O)OC)c1ccccc1",
        "output": "195"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCC(Oc2ccc(-c3n[nH]c4ccc(N)cc34)cc2)CC1.F[B-](F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(c1ccccc1)C1CC1>>CN1CCC(Oc2ccc(-c3n[nH]c4ccc(NC(=O)C(c5ccccc5)C5CC5)cc34)cc2)CC1",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1cnc(Cl)c([N+](=O)[O-])c1.C[O-].[Na+]>>COC(=O)c1cnc(OC)c([N+](=O)[O-])c1",
        "output": "433"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl.C[S-].[Na+]>>Cc1c(Cl)c(O)nc2sc(C(=O)NC3CC3)c(N)c12",
        "output": "408"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNCC1.CCO.Cc1c(C(=O)N2CCN(C)CC2)c[nH]c1C=O.O=C1Cc2c(cccc2-c2ccccc2F)N1>>Cc1c(C(=O)N2CCN(C)CC2)c[nH]c1C=C1C(=O)Nc2cccc(-c3ccccc3F)c21",
        "output": "440"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.Cl.ClCCl.NCCCCN1C(=O)c2cccc(NC(=O)c3ccc(Cl)s3)c2C1=O.O=C(Cl)c1ccncc1.O=C(O)C(F)(F)F>>O=C(NCCCCN1C(=O)c2cccc(NC(=O)c3ccc(Cl)s3)c2C1=O)c1ccncc1",
        "output": "271"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCNC(=O)Nc1cccc(-n2c([C@H](C)O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)nc3cccc(Cl)c3c2=O)c1.CCOC(C)=O.O=C([O-])O.O=C1CC[C@@H](C(=O)O)N1.[Na+]>>CCNC(=O)Nc1cccc(-n2c([C@H](C)O)nc3cccc(Cl)c3c2=O)c1",
        "output": "781"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.Br.BrCCCN1CCCCC1.CCN(CC)CCCBr.CCN(CC)CCCn1nc(N)c2c(Cl)cccc21.Nc1n[nH]c2ccc(Cl)cc12.Nc1n[nH]c2cccc(Cl)c12>>Nc1nn(CCCN2CCCCC2)c2ccc(Cl)cc12",
        "output": "577"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)c1ccc(N=C=O)cc1.CC[C@H](N)CC(=O)OC.ClCCl>>CC[C@@H](CC(=O)OC)NC(=O)Nc1ccc(C(C)(C)C)cc1",
        "output": "35"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1nnn(-c2ccccc2F)c1-c1cn(-c2ccc(C(=O)O)cn2)cn1.NC1CCOCC1>>Cc1nnn(-c2ccccc2F)c1-c1cn(-c2ccc(C(=O)NC3CCOCC3)cn2)cn1",
        "output": "674"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O.CCOC(=O)c1cn2nc(SC)sc2n1.C[Si](C)(C)O[Na]>>CSc1nn2cc(C(=O)O)nc2s1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCOC(C)=O.CCOC(C)=O.CO.COc1cc(C(=O)N2CCC(CCOS(C)(=O)=O)(c3ccccc3)C2)cc(OC)c1OC.Cl.OCCn1c(N2CCCNCC2)nc2ccccc21.[I-].[K+]>>COc1cc(C(=O)N2CCC(CCN3CCCN(c4nc5ccccc5n4CCO)CC3)(c3ccccc3)C2)cc(OC)c1OC",
        "output": "496"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)c1cc(S(=O)(=O)Nc2cc(Cl)cnc2Br)ccc1Cl.CCOCC.C[Mg]Br>>CC(C)(O)c1cc(S(=O)(=O)Nc2cc(Cl)cnc2Br)ccc1Cl",
        "output": "586"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCc1cc(Oc2cnccn2)ccc1O.CCOC(=O)C(O)c1ccc(OCCCBr)cc1>>CCCc1cc(Oc2cnccn2)ccc1OCCCOc1ccc(C(O)C(=O)OCC)cc1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)c1ccncc1.Cc1nc(N)sc1C(=O)NCc1ccccc1.O=C(Cl)c1ccccc1>>Cc1nc(NC(=O)c2ccccc2)sc1C(=O)NCc1ccccc1",
        "output": "673"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1nc(N2CCN(c3ccccc3)CC2)nc2c1ccc(=O)n2-c1ccc(C(=O)O)cc1.ClCCl.O=C(Cl)C(=O)Cl>>Cc1nc(N2CCN(c3ccccc3)CC2)nc2c1ccc(=O)n2-c1ccc(C(=O)Cl)cc1",
        "output": "448"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.C=C/C=C/C1(C)CCN(C(=O)OC(C)(C)C)CC1.Cl>>C=C/C=C/C1(C)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)c1ccc(O)cc1.CO.COc1ccc(C=O)cc1.Cl.[Na+].[OH-]>>COc1ccc(C=CC(=O)c2ccc(O)cc2)cc1",
        "output": "295"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C[N+](=O)[O-].Cl.ClC(Cl)C(Cl)Cl.O=C(O)c1ccc(C(=O)O)cc1.O=S(=O)(O)O.Oc1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(O)c1ccc(C(=O)c2ccc(O)cc2)cc1",
        "output": "275"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)NCCc4ccc5c(c4)OCO5)cc3)c(Cl)cc21.CCOC(C)=O.Cl.OCCC1CCCO1.[Na+].[OH-]>>O=C(NCCc1ccc2c(c1)OCO2)c1ccc(Oc2cc3c(cc2Cl)C(C(=O)O)CCO3)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(C(=O)C(C)(C)Br)cc1OC.Cc1ccccc1.Cl.[Al+3].[Br-].[Br-].[Br-]>>COc1cc(C(=O)C(C)(C)Br)ccc1O",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCOc1cc(F)c(F)c(Nc2ccc(I)cc2Cl)c1[N+](=O)[O-].CCO.O.O=S([O-])S(=O)[O-].[Na+].[Na+]>>C=CCOc1cc(F)c(F)c(Nc2ccc(I)cc2Cl)c1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CNCCO.O=C([O-])[O-].O=[N+]([O-])c1cccnc1Cl.[K+].[K+]>>CN(CCO)c1ncccc1[N+](=O)[O-]",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCCCC1.CN(C)C=O.Cc1c(-c2cccnc2)[nH]c2ccccc12.N#Cc1ccc(CBr)cc1.[H-].[Na+]>>Cc1c(-c2cccnc2)n(Cc2ccc(C#N)cc2)c2ccccc12",
        "output": "528"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(C(C)C)C(C)C.CCOC(=O)/C=C/c1cccc2c1CCNC2.Cl.ClCCl.O.O=CC1CC1.[Na+]>>CCOC(=O)/C=C/c1cccc2c1CCN(CC1CC1)C2",
        "output": "858"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.Nc1cc(Cl)c([N+](=O)[O-])cc1O.O=C(Cl)c1ccc(Cl)c(Cl)c1>>O=C(Nc1cc(Cl)c([N+](=O)[O-])cc1O)c1ccc(Cl)c(Cl)c1",
        "output": "11"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(NCC1CC1)[C@@H]1CCNC1.O=Cc1ccc(F)c(C(=O)O)c1>>O=Cc1ccc(F)c(C(=O)N2CC[C@@H](C(=O)NCC3CC3)C2)c1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.Cc1c(Cl)[nH]c(=O)n(Cc2ccccc2)c1=O.ClCCCBr.O=C([O-])[O-].[K+].[K+]>>Cc1c(Cl)n(CCCCl)c(=O)n(Cc2ccccc2)c1=O",
        "output": "327"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1ccc(OC(C)C(=O)OC)c(C=O)c1.CO.C[O-].[BH4-].[Na+].[Na+]>>CCc1ccc(OC(C)C(=O)OC)c(CO)c1",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)CC(C)n1cnc2cc(N)ccc21.Cl>>CC(CC(=O)O)n1cnc2cc(N)ccc21",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CO.Cl.N[C@H]1CCN(c2cccc(Br)n2)C1.O=Cc1ccc(Cl)cc1Cl.[BH4-].[Na+]>>Clc1ccc(CN[C@H]2CCN(c3cccc(Br)n3)C2)c(Cl)c1",
        "output": "468"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1ccc2c(N)ncnc21.CC(=O)OC(C)=O.CCN(CC)CC.CN(C)C=O>>C#C[C@@]1(O)[C@H](OC(C)=O)[C@@H](CO)O[C@H]1n1ccc2c(N)ncnc21",
        "output": "254"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1nc(N)ccc1COCC1CC1.O=S(=O)(Cl)c1cc(F)ccc1F>>Cc1nc(NS(=O)(=O)c2cc(F)ccc2F)ccc1COCC1CC1",
        "output": "462"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCN.CCN(CC)CC.CCN(CC)CCCNc1nc(-c2cccc(C(=O)O)c2)c2ccc(=O)n(-c3c(F)cccc3F)c2n1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F>>CCCNC(=O)c1cccc(-c2nc(NCCCN(CC)CC)nc3c2ccc(=O)n3-c2c(F)cccc2F)c1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(Cl)c(B(O)O)c1.Nc1ccc(Br)cc1F>>COc1ccc(Cl)c(-c2ccc(N)c(F)c2)c1",
        "output": "837"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(OC)c(Cl)c(-c2cc3cnc(SC)nc3n(CCCN3[C@H](C)CN(C(=O)OC(C)(C)C)C[C@@H]3C)c2=O)c1.ClCCl.O=C(OO)c1cccc(Cl)c1>>COc1cc(OC)c(Cl)c(-c2cc3cnc(S(C)=O)nc3n(CCCN3[C@H](C)CN(C(=O)OC(C)(C)C)C[C@@H]3C)c2=O)c1",
        "output": "595"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1cc(OCC(F)(F)C(F)(F)F)nn1-c1cc(SCC(F)(F)F)c(C)cc1F.Cl.O.[K+].[OH-]>>Cc1cc(F)c(-n2nc(OCC(F)(F)C(F)(F)F)cc2C(=O)O)cc1SCC(F)(F)F",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CCO.CCOCC.Oc1ccccc1Br.[Na+].[OH-]>>Brc1ccccc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1[nH]c(C=C2C(=O)Nc3ccc(Cl)cc32)c(C)c1C(=O)O.NCC(O)CN1CCOCC1>>Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(Cl)cc32)c(C)c1C(=O)NCC(O)CN1CCOCC1",
        "output": "674"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.CO.ClC(Cl)Cl.O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1C(F)(F)F.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2cc(C(F)(F)F)c(=O)[nH]c2=O)C[C@@H]1O",
        "output": "193"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(O)c([N+](=O)[O-])c1[N+](=O)[O-].ClCC1CO1.[Na+].[OH-]>>Cc1ccc(OCC2CO2)c([N+](=O)[O-])c1[N+](=O)[O-]",
        "output": "15"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOCC1.CCOC(=O)c1ccccc1CCC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1.CO.O.O.[Li+].[OH-]>>O=C(CCc1ccccc1C(=O)O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1",
        "output": "5"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)Cc1csc(N2CC[C@H](N)[C@H](OC)C2)n1.CCc1[nH]c(C(=O)O)nc1Cl.Cl.On1nnc2ccccc21>>CCOC(=O)Cc1csc(N2CC[C@H](NC(=O)c3nc(Cl)c(CC)[nH]3)[C@H](OC)C2)n1",
        "output": "951"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C1NCCc2ccccc21.O=C(O)c1cc2ncc(Br)cn2n1>>CC(C)C1c2ccccc2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "952"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CC[C@H]1C2=CC[C@@H](C(F)(F)F)[C@@H]1C=O.Nc1cccc(F)c1>>C[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CC[C@H]1C2=CC[C@@H](C(F)(F)F)[C@@H]1CNc1cccc(F)c1",
        "output": "336"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C/C(=C(\\F)CO)c1cc2c(c(Br)c1OC(C)C)C(C)(C)CC=C2C(C)(C)C.CC#N.CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-]>>C/C(=C(\\F)C=O)c1cc2c(c(Br)c1OC(C)C)C(C)(C)CC=C2C(C)(C)C",
        "output": "183"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.O=C(O)c1c[nH]cn1.On1nnc2ccccc21.c1ccc2c(c1)CC(Nc1ncc3c(n1)CCNC3)C2>>O=C(c1c[nH]cn1)N1CCc2nc(NC3Cc4ccccc4C3)ncc2C1",
        "output": "729"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc2cc(-n3c(C)nnc3C)cc(C)c2n1.Cl.O=C([O-])[O-].[Na+].[Na+]>>Cc1cc(-n2c(C)nnc2C)cc2ccc(=O)[nH]c12",
        "output": "758"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(C)=O.FCCBr.N#Cc1ccc2cc(O)ccc2c1.O=C([O-])[O-].[K+].[K+]>>N#Cc1ccc2cc(OCCF)ccc2c1",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)Cc1ccc(C(F)(F)F)cc1[N+](=O)[O-].ClCCl.O=C(O)C(F)(F)F>>O=C(O)Cc1ccc(C(F)(F)F)cc1[N+](=O)[O-]",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCCN1CCc2ccc(N)cc2CC1.Fc1cccc(OC2CCOCC2)c1Nc1nc(Cl)ncc1Cl>>COCCN1CCc2ccc(Nc3ncc(Cl)c(Nc4c(F)cccc4OC4CCOCC4)n3)cc2CC1",
        "output": "808"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.N#CCc1ccc(C(=O)O)cc1.O=S(Cl)Cl>>N#CCc1ccc(C(=O)Cl)cc1",
        "output": "3"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC1(CCOc2ccnc(COC(C)=O)c2C)OCCO1.CO.[Na+].[OH-]>>CCCC1(CCOc2ccnc(CO)c2C)OCCO1",
        "output": "348"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCC(C)(C)S(=O)(=O)C[C@@H](Cc1ccccc1)C(=O)O.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)C1CC1.On1nnc2ccccc21>>CC(C)(C)OC(=O)NCC(C)(C)S(=O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)C1CC1",
        "output": "133"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCCCCCCCCCCCCN(C(=O)CCCCCCCCCCC)[C@]1(N)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1C(=O)CN.NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)O>>CCCCCCCCCCCCCCCCCCN(C(=O)CCCCCCCCCCC)[C@]1(N)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1C(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)OCc1ccccc1",
        "output": "645"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "B.C1CCOC1.C1CCOC1.CCOC(=O)c1c(CCCOc2cccc3ccccc23)c2cccc(Br)c2n1CC(=O)N1CCOCC1>>CCOC(=O)c1c(CCCOc2cccc3ccccc23)c2cccc(Br)c2n1CCN1CCOCC1",
        "output": "112"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cc1cc(C=C(C(=O)O)c2ccc(O)cc2)ccc1F.O=S(=O)(O)O>>COC(=O)C(=Cc1ccc(F)c(C)c1)c1ccc(O)cc1",
        "output": "174"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.Nc1ccc(Cl)cc1I.c1ccncc1>>CC(C)(C)OC(=O)Nc1ccc(Cl)cc1I",
        "output": "735"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCCCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.CCOC(C)=O.CN(C)Cc1c(OCC2CC2)ccc2c(CCC3CCN(CC4(CO[Si](c5ccccc5)(c5ccccc5)C(C)(C)C)CC4)CC3)noc12.[Cl-].[F-].[NH4+]>>CN(C)Cc1c(OCC2CC2)ccc2c(CCC3CCN(CC4(CO)CC4)CC3)noc12",
        "output": "781"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccccc1.ClCCl.O=S(Cl)Cl.O=[N+]([O-])c1cccc(Cl)c1CCO>>O=[N+]([O-])c1cccc(Cl)c1CCCl",
        "output": "96"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(CC)CC.Cl.Cl.ClCCl.NCCCOc1cccc2nccn12.O=S(=O)(Cl)c1ccccc1>>O=S(=O)(NCCCOc1cccc2nccn12)c1ccccc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)CCS(=O)(=O)Cl.Cc1ccc(NC(=O)Nc2nc(CN)cs2)c(C(=O)C2CCCC2)c1>>COC(=O)CCS(=O)(=O)NCc1csc(NC(=O)Nc2ccc(C)cc2C(=O)C2CCCC2)n1",
        "output": "493"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)O.CCN(C(C)C)C(C)C.CCOCC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.Cl.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)-c1ccccc1C2N1CCNCC1>>CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N1CCN(C2c3ccccc3-c3ccccc32)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCNc1nc(Cl)nc2ccc([N+](=O)[O-])cc12.CC(C)(C)N.O>>C=CCNc1nc(NC(C)(C)C)nc2ccc([N+](=O)[O-])cc12",
        "output": "544"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(C)=O.COC(=O)c1c[nH]c(-c2ccc(C3CCCCC3)cc2)c1.Cc1ccccc1.Cl.[H-]>>OCc1c[nH]c(-c2ccc(C3CCCCC3)cc2)c1",
        "output": "522"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCBr.CN(C)C=O.O.O=C([O-])[O-].O=Cc1cnc2cc(O)ccc2c1.[K+].[K+]>>CCCCCCCOc1ccc2cc(C=O)cnc2c1",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCOC(=O)NC(CC(=O)OCC)c1cccc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1.CCO.Cl[Sn]Cl.[Na+].[OH-]>>C=CCOC(=O)NC(CC(=O)OCC)c1cccc(NS(=O)(=O)c2cccc(N)c2)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1NCc2nc(NC3CCOCC3)ncc21.CCN(C(C)C)C(C)C.C[C@@H](N=C=O)c1cccc(Cl)c1.ClCCl>>CC1c2cnc(NC3CCOCC3)nc2CN1C(=O)N[C@H](C)c1cccc(Cl)c1",
        "output": "583"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COC(=O)c1csc(C=O)c1.[BH4-].[Na+]>>COC(=O)c1csc(CO)c1",
        "output": "529"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C1CCc2oc3ccc(C(=O)O)cc3c2C1.Nc1cccnc1>>CN(C)C1CCc2oc3ccc(C(=O)Nc4cccnc4)cc3c2C1",
        "output": "759"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC[C@@H](c1ccccc1)N(Cc1ccc(C(=O)OC)cc1)S(=O)(=O)c1ccc(Cl)cc1.O.O.[Li+].[OH-]>>CC[C@@H](c1ccccc1)N(Cc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccc(Cl)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)[C@@H](N)CCCCN.Cl.Cl.O=C(O)CNC(=O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(Cl)cc2Cl)cc1>>COC(=O)[C@@H](N)CCCCNC(=O)CNC(=O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(Cl)cc2Cl)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.CCN1C(=O)C(C)(C)c2ccc(N)cc21>>CCN1C(=O)C(C)(C)c2ccc(NC(C)=O)cc21",
        "output": "6"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CN1CCCC1=O.COCOc1cc(F)c(Br)cc1F.OCc1ccncc1.[H-].[Na+]>>COCOc1cc(OCc2ccncc2)c(Br)cc1F",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)CNC(=O)c1cc(-c2cccc(OCc3ccccc3)c2)[nH]n1.CO.O.O.[Li]O>>O=C(O)CNC(=O)c1cc(-c2cccc(OCc3ccccc3)c2)[nH]n1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCc1c(O)c(C)cc2ccc(=O)oc12.CC(=O)OC(C)=O.CC(=O)O[Na].O>>C=CCc1c(OC(C)=O)c(C)cc2ccc(=O)oc12",
        "output": "46"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1=CCCCC1.CCO.COc1ccc(-c2nc(C(F)F)oc2-c2ccc(OCc3ccccc3)cc2)cn1.[OH-].[OH-].[Pd+2]>>COc1ccc(-c2nc(C(F)F)oc2-c2ccc(O)cc2)cn1",
        "output": "23"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCC(CC(=O)c1ccc(OC)cc1)C(F)(F)F.CCOCC.O=S(=O)(O)O.[Al+3].[Al+3].[Cl-].[Cl-].[Cl-].[H-].[H-].[H-].[H-].[Li+]>>CCCCC(CCc1ccc(OC)cc1)C(F)(F)F",
        "output": "92"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.C[C@@H]1CNC[C@H]1NC(=O)OC(C)(C)C.ClCCl.O=C(Cl)c1ccccc1>>C[C@@H]1CN(C(=O)c2ccccc2)C[C@H]1NC(=O)OC(C)(C)C",
        "output": "201"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC1=C(c2c(C)cc(Br)cc2C)C(=O)CC1CC#N.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[K+].[Pd].[Pd]>>COC1=C(c2c(C)cc(B3OC(C)(C)C(C)(C)O3)cc2C)C(=O)CC1CC#N",
        "output": "942"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cc(C)nn1CCOC.CCOC(C)=O.Cl.[Na+].[OH-]>>COCCn1nc(C)cc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CO.COc1cc(C)c(-c2nc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)cc(C)c2C)cn1.C[Si](C)(C)I>>Cc1cc(O)ncc1-c1nc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)cc(C)c1C",
        "output": "408"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CN(C)C=O.COC(=O)CCc1ccc(O)cc1.[H-].[Na+]>>COC(=O)CCc1ccc(OCc2ccccc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C[C@@H](COC1CCCCO1)n1cc(C(=O)c2cncc(N)c2)c2cncnc21.O=C(O)Cn1nc2ccccc2n1>>C[C@@H](COC1CCCCO1)n1cc(C(=O)c2cncc(NC(=O)Cn3nc4ccccc4n3)c2)c2cncnc21",
        "output": "724"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C(N[C@H]1CCN(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1)c1coc(N2CC(O)C2)n1>>CS(=O)(=O)OC1CN(c2nc(C(=O)N[C@H]3CCN(C(=O)OCc4ccc([N+](=O)[O-])cc4)C3)co2)C1",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(Oc2ccc(Nc3ncnc4ccc(NC5=NC6CN(C(=O)OC(C)(C)C)CC6O5)cc34)cc2C)cn1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(Oc2ccc(Nc3ncnc4ccc(NC5=NC6CNCC6O5)cc34)cc2C)cn1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCI.CN(C)C=O.O=C([O-])[O-].O=Cc1cccc(OC(F)(F)F)c1O.[K+].[K+]>>CCOc1c(C=O)cccc1OC(F)(F)F",
        "output": "198"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.CC(C)(C#N)C(O)CC[Si](C)(C)C(C)(C)C.CCN(CC)CC.CCOCC.CN(C)c1ccncc1>>CC(=O)OC(CC[Si](C)(C)C(C)(C)C)C(C)(C)C#N",
        "output": "254"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCl.Nc1cccc2cccnc12.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>O=[N+]([O-])c1ccccc1S(=O)(=O)Nc1cccc2cccnc12",
        "output": "554"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)c1ccc(NC2CCNCC2)cc1.CCCCCO.COc1cc2cnc(Cl)nc2cc1OC>>COc1cc2cnc(N3CCC(Nc4ccc(C(=O)OC(C)(C)C)cc4)CC3)nc2cc1OC",
        "output": "36"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCC(CC)(c1ccc(OCC(O)C(C)(C)C)c(C)c1)c1cc2cc(C(=O)OC)ccc2o1.CO.[Na+].[OH-]>>CCC(CC)(c1ccc(OCC(O)C(C)(C)C)c(C)c1)c1cc2cc(C(=O)O)ccc2o1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCc2oc3ccc(S(=O)(=O)c4ccc(F)cc4)cc3c2C1.ClCCl.O=C(O)C(F)(F)F>>O=S(=O)(c1ccc(F)cc1)c1ccc2oc3c(c2c1)CNCC3",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.CO.C[S-].O=C1Nc2ccccc2OC1CCBr.[Na+]>>CSCCC1Oc2ccccc2NC1=O",
        "output": "185"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.NC(=O)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1N(CCO)CCI.O=C([O-])O.[Na+]>>CS(=O)(=O)OCCN(CCI)c1c(C(N)=O)cc([N+](=O)[O-])cc1[N+](=O)[O-]",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.Cc1ccc2c(c1)N(CC(=O)c1ccsc1)C(=O)C(NC(=O)OC(C)(C)C)CN2C(=O)C(C)(C)C.Cl>>Cc1ccc2c(c1)N(CC(=O)c1ccsc1)C(=O)C(N)CN2C(=O)C(C)(C)C",
        "output": "431"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N1CCc2c(c(-c3ccc(C(F)(F)F)cc3)nn2CC2CO2)C1.CO.ClCCl.ClCCl.N#Cc1ccccc1N1CCNCC1.O.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3]>>CC(=O)N1CCc2c(c(-c3ccc(C(F)(F)F)cc3)nn2CC(O)CN2CCN(c3ccccc3C#N)CC2)C1",
        "output": "76"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(CNCc1ccccc1)C(C)O[Si](C)(C)C(C)(C)C.CO.[H][H].[Pd]>>CCOC(=O)C(CN)C(C)O[Si](C)(C)C(C)(C)C",
        "output": "561"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1ncc2onc(-c3ccccc3)c2c1O.C[C@H](N)C(=O)O>>C[C@H](NC(=O)c1ncc2onc(-c3ccccc3)c2c1O)C(=O)O",
        "output": "977"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.C[C@@H]1C[C@@H](O)c2ncnc(-c3ccc(C(=O)O)s3)c21.ClCCl.F[P-](F)(F)(F)(F)F.[N-]=[N+]=NC[C@@H](N)Cc1ccc(Cl)cc1Cl>>C[C@@H]1C[C@@H](O)c2ncnc(-c3ccc(C(=O)N[C@H](CN=[N+]=[N-])Cc4ccc(Cl)cc4Cl)s3)c21",
        "output": "736"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)Cn1c(Cl)nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc21.CN1CCCC1=O.C[C@@H]1CN[C@@H](C)CN1>>CC(C)Cn1c(N2C[C@@H](C)NC[C@@H]2C)nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc21",
        "output": "36"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.O.O=[N+]([O-])c1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1.O=[Pt]>>Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1CC(O)(c2ccccc2)CN1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O=C(O)c1cn[nH]c1-c1ccc(F)cc1.c1ccncc1>>CC1CC(O)(c2ccccc2)CN1C(=O)c1cn[nH]c1-c1ccc(F)cc1",
        "output": "733"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)CCC(C)(C)c2cc(C(F)(F)C(=O)O)ccc21.CCN(CC)CC.CN(C)C=O.CN(C)c1ccncc1.COC(=O)c1ccc(CN)cc1.ClCCl.O=S(Cl)Cl.[Cl-].[NH4+]>>COC(=O)c1ccc(CNC(=O)C(F)(F)c2ccc3c(c2)C(C)(C)CCC3(C)C)cc1",
        "output": "599"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.NNC1=Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1.O=C(CO)CCl>>OCC(CCl)=NNC1=Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1",
        "output": "285"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)C(C)(C)NC(=O)Cc1ccc(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)cc1.CCOCC.ClCCl.O=C(O)C(F)(F)F>>CC(C)(NC(=O)Cc1ccc(-n2c(N)c(C(=O)c3ccc(F)cc3F)ccc2=O)cc1)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.C1COCCO1.CC1(C)OB(c2ccc(OC(F)F)cc2)OC1(C)C.Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)cnc1Cl.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)cnc1-c1ccc(OC(F)F)cc1",
        "output": "955"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COC(=O)c1cnc(Cl)cn1.OC1CCN(c2ccc(C(F)(F)F)cc2)CC1.[H-].[Na+]>>COC(=O)c1cnc(OC2CCN(c3ccc(C(F)(F)F)cc3)CC2)cn1",
        "output": "209"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[O-].CI.CN(C)C=O.COC(=O)c1c[nH]c(Br)c1.[K+]>>COC(=O)c1cc(Br)n(C)c1",
        "output": "191"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccnc(N2CCNCC2)n1.Cl.O=CCCCOc1ccc2c(n1)NC(=O)CC2>>Cc1ccnc(N2CCN(CCCCOc3ccc4c(n3)NC(=O)CC4)CC2)n1",
        "output": "484"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.N#N.[Pd].c1ccc(COc2ccc3cc[nH]c3c2)cc1>>Oc1ccc2cc[nH]c2c1",
        "output": "23"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.ClCCCl.NCCc1ccccc1C(F)(F)F.O=C(O)Cn1nc(-c2ccc(Cl)cc2)n(Cc2ccccc2F)c1=O.On1nnc2ccccc21>>O=C(Cn1nc(-c2ccc(Cl)cc2)n(Cc2ccccc2F)c1=O)NCCc1ccccc1C(F)(F)F",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(N)CO.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1nc(CCc2c(-c3ccccc3)noc2C)sc1C(=O)O.F[B-](F)(F)F>>Cc1nc(CCc2c(-c3ccccc3)noc2C)sc1C(=O)NC(C)CO",
        "output": "534"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1c(C(C)=O)cc(Cl)c(F)c1C1CN(C(=O)OC(C)(C)C)C1.[BH4-].[Na+]>>COc1c(C(C)O)cc(Cl)c(F)c1C1CN(C(=O)OC(C)(C)C)C1",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cc1ccc([N+](=O)[O-])cc1CC(=O)N1CCC(c2c[nH]c3c(Cl)cccc23)CC1.Cl.[Fe]>>Cc1ccc(N)cc1CC(=O)N1CCC(c2c[nH]c3c(Cl)cccc23)CC1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.CC(=O)[O-].CC(=O)[O-].CCCCc1nc(C)n(-c2cccc(Br)c2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.Cc1ccccc1.O.O=P([O-])([O-])[O-].OB(O)C1CC1.[K+].[K+].[K+].[Pd+2]>>CCCCc1nc(C)n(-c2cccc(C3CC3)c2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "956"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cccc(N)c1.O=C(O)c1ccc(Cl)c(C(F)(F)F)c1>>COc1cccc(NC(=O)c2ccc(Cl)c(C(F)(F)F)c2)c1",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CCN.CCOC(C)=O.Clc1cc(Br)ccn1.O>>CCN(CC)CCNc1cc(Br)ccn1",
        "output": "70"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(O)CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1",
        "output": "91"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1ccc(C#C[Si](C)(C)C)cc1.O=C([O-])[O-].[K+].[K+]>>C#Cc1ccc(C(=O)OCC)cc1",
        "output": "337"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(Cc2ccccc2)CO1.O=C1C(=O)c2ccccc2C2=C1SCC1(CCNCC1)O2>>CC(O)(Cc1ccccc1)CN1CCC2(CC1)CSC1=C(O2)c2ccccc2C(=O)C1=O",
        "output": "76"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCC1CC1.CC(C)(C)[O-].CCOC(C)=O.CCOc1cc(Cc2cnc(N)nc2N)cc(O)c1-c1cccc(N)c1.CN(C)C=O.O.[K+]>>CCOc1cc(Cc2cnc(N)nc2N)cc(OCC2CC2)c1-c1cccc(N)c1",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1N.CN(C)C=O.Cn1nnnc1-c1cccc(NC(=O)Oc2ccccc2)c1>>Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN(CCCc2ccc(F)cc2)C(=O)OC(C)(C)C)c1",
        "output": "488"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[SiH2]OC(C)(C)c1ccc(N)nc1.CC(C)Oc1cc(OCCc2ccsc2)cc(C(=O)O)c1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.c1ccncc1>>CC(C)Oc1cc(OCCc2ccsc2)cc(C(=O)Nc2ccc(C(C)(C)O[SiH2]C(C)(C)C)cn2)c1",
        "output": "744"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)O.CCCCc1nc(Cl)c(COCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.O>>CCCCc1nc(Cl)c(COCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1",
        "output": "815"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N1CCC(C(=O)c2ccc(F)cc2)CC1.Cc1ccc(S(=O)(=O)O)cc1.O.OCCO.c1ccccc1>>CC(=O)N1CCC(C2(c3ccc(F)cc3)OCCO2)CC1",
        "output": "93"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(S(=O)(=O)Cl)cc1.c1ccc2[nH]ccc2c1>>COc1ccc(S(=O)(=O)n2ccc3ccccc32)cc1",
        "output": "648"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(-c2ncc(C(=O)NCC3(O)CCN(C(=O)OC(C)(C)C)CC3)n2N)cc1.O.O=C([O-])O.O=CO.[Na+]>>Cc1ccc(-c2ncc(C(=O)NCC3(O)CCNCC3)n2N)cc1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CO.COc1ccc2cc(C)c(Cl)nc2c1.[H][H].[Pd]>>COc1ccc2cc(C)cnc2c1",
        "output": "40"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[Si](C)(C)N1C(=O)C[C@@H]1C(=O)O.CN(C)c1ccncc1.ClCCCl.ClCCl.O.OCc1ccccc1>>CC(C)(C)[Si](C)(C)N1C(=O)C[C@@H]1C(=O)OCc1ccccc1",
        "output": "536"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC[Sn](Cl)(CCCC)CCCC.CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C#N)nc1.[N-]=[N+]=[N-].[Na+]>>CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)nc1",
        "output": "390"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CNCCN1.Clc1cncc(OCCCCCOc2ccccc2)n1.O=C([O-])[O-].O=[O+][O-].OCCCCCOc1ccccc1.[K+].[K+]>>c1ccc(OCCCCCOc2cncc(N3CCNCC3)n2)cc1",
        "output": "505"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN.O=S1(=O)N(CCCBr)c2ccccc2N1c1ccccc1F>>CNCCCN1c2ccccc2N(c2ccccc2F)S1(=O)=O",
        "output": "147"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.CCOC(=O)CBr.C[C@@H](Cn1ncc2ccc(O)c(Br)c21)NC(=O)OCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)COc1ccc2cnn(C[C@H](C)NC(=O)OCc3ccccc3)c2c1Br",
        "output": "123"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCl.O=C(O)c1c(Cl)cc(Br)cc1Cl.O=S(Cl)Cl>>O=C(Cl)c1c(Cl)cc(Br)cc1Cl",
        "output": "3"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(/C(C#N)=C/c2cn(Cc3ccc(F)cc3)c3cc(Cl)ccc23)cc1.CO.[Na+].[OH-]>>N#C/C(=C\\c1cn(Cc2ccc(F)cc2)c2cc(Cl)ccc12)c1ccc(C(=O)O)cc1",
        "output": "5"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.ClCCl.O=C(O)C1(c2ccc(-c3ccc(Cl)c(Cl)c3)c(F)c2)CC1.OCC1CO1>>O=C(OCC1CO1)C1(c2ccc(-c3ccc(Cl)c(Cl)c3)c(F)c2)CC1",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CN[C@@H](CN2CCCC2)C1.CC1(C)OB(c2ccc(C(=O)O)cc2)OC1(C)C>>CC1(C)OB(c2ccc(C(=O)N3CCC[C@@H]3CN3CCCC3)cc2)OC1(C)C",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.NCCC(=O)O.O=C([O-])O.O=[N+]([O-])c1ccc(F)c([N+](=O)[O-])c1.[Na+]>>O=C(O)CCNc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]",
        "output": "572"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCc1nsc(C(=O)NC(C)C)c1C(=O)OC.O.[K+].[OH-]>>CCc1nsc(C(=O)NC(C)C)c1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1cccc(C(OCCNC(=O)OC)c2cc(Cl)ccc2C)c1.CO.O.[Li+].[OH-]>>COC(=O)NCCOC(c1cccc(C(=O)O)c1)c1cc(Cl)ccc1C",
        "output": "5"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cnn(C2CCN(C(=O)OC(C)C)CC2)c1Br.CCOC(C)=O.CO.[Na+].[OH-]>>CC(C)OC(=O)N1CCC(n2ncc(CO)c2Br)CC1",
        "output": "471"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1cc2c(=O)n3cc(C(N)=O)ccc3nc2s1.ClC(Cl)Cl.O=P(Cl)(Cl)Cl>>Cc1cc2c(=O)n3cc(C#N)ccc3nc2s1",
        "output": "624"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1c(N(C(C)=O)C(=O)OC(C)(C)C)c2cc(O)ccc2n1-c1ccc(OC(C)C)cc1.OB(O)c1ccc(OC(F)(F)F)cc1>>CCOC(=O)c1c(N(C(C)=O)C(=O)OC(C)(C)C)c2cc(Oc3ccc(OC(F)(F)F)cc3)ccc2n1-c1ccc(OC(C)C)cc1",
        "output": "920"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)C(CC(C)C)c1cc(O)cc(-c2cc(F)cc(C(F)(F)F)c2)c1.OB(O)c1cccc(C(F)(F)F)c1>>COC(=O)C(CC(C)C)c1cc(Oc2cccc(C(F)(F)F)c2)cc(-c2cc(F)cc(C(F)(F)F)c2)c1",
        "output": "920"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "N.O=C(O)Cn1ncc2c(-c3ccc(F)cc3)c(-c3ccncc3)c(-c3ccc(F)cc3)nc21>>NC(=O)Cn1ncc2c(-c3ccc(F)cc3)c(-c3ccncc3)c(-c3ccc(F)cc3)nc21",
        "output": "313"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.CNCCc1ccccc1.O=C(Cl)CCl>>CN(CCc1ccccc1)C(=O)CCl",
        "output": "125"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Nc1cc(Br)ccn1.ClCCl.O.O=C(OO)c1cccc(Cl)c1.O=C([O-])[O-].[K+].[K+]>>CC(=O)Nc1cc(Br)cc[n+]1[O-]",
        "output": "262"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CO.FC(F)(F)c1ccc([C@@]23CNC[C@@H]2C3)cc1.O=CCCn1cc(-c2cnccn2)c(=O)[nH]c1=O.[Na+].[Na+].[OH-]>>O=c1[nH]c(=O)n(CCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)cc1-c1cnccn1",
        "output": "484"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)CCOCCc1ccc2ccccc2c1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)CCOCCc1ccc2ccccc2c1",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C(=O)O)c1ccc(COCCO)c(F)c1.CC(C)(C)c1cc(CN)n(-c2cccc(Cl)c2)n1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.On1nnc2ccccc21>>CC(C(=O)NCc1cc(C(C)(C)C)nn1-c1cccc(Cl)c1)c1ccc(COCCO)c(F)c1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cn1c(Cl)nc2c(Cl)ccc(C(CC)CC)c21.CN1CCCC1=O.Nc1ccc(Cl)cc1Cl.O=C([O-])O.[Na+]>>CCOC(=O)Cn1c(Nc2ccc(Cl)cc2Cl)nc2c(Cl)ccc(C(CC)CC)c21",
        "output": "808"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CBr.CN(C)C=O.O.O=C([O-])[O-].Oc1c(F)cc(Br)cc1Cl.[K+].[K+]>>CC(C)COc1c(F)cc(Br)cc1Cl",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.COC(=O)c1cc2cc(F)c(OCc3ccccc3)cc2[nH]1.[Pd]>>COC(=O)c1cc2cc(F)c(O)cc2[nH]1",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CN.O.O=C1c2ccccc2C(=O)N1C[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1.[Cl-].[Na+]>>NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1",
        "output": "242"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CN(C)C=O.Cl.N#Cc1ccc2oc3cc([N+](=O)[O-])ccc3c2c1.NO.O>>N=C(NO)c1ccc2oc3cc([N+](=O)[O-])ccc3c2c1",
        "output": "854"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cc(Cl)c2ccccc2n1.O.O=[Se]=O>>O=Cc1cc(Cl)c2ccccc2n1",
        "output": "619"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.NCc1cccc(Cl)c1.O=C(Cl)c1ccc(CCl)cc1>>O=C(NCc1cccc(Cl)c1)c1ccc(CCl)cc1",
        "output": "411"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1ccc2scnc2c1.O.[Na+].[OH-]>>O=C(O)c1ccc2scnc2c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCc1cc2nccn2cc1-c1ccc(Cl)cc1Cl.ClCCl.O=C(O)C(F)(F)F>>NCc1cc2nccn2cc1-c1ccc(Cl)cc1Cl",
        "output": "538"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCC.CN(C)C=O.Cc1cc(F)cc(F)c1.O=S(=O)(O)O.[Li]CCCC>>Cc1cc(F)c(C=O)c(F)c1",
        "output": "239"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCOC(=O)CC1CCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21.Cl.O.[Li]O>>O=C(O)CC1CCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CS(C)=O.C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)NC3CC3)cc2)nc2c1CNC2.ClCCCl.O.O=C(O)C1CC1.On1nnc2ccccc21>>C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)NC3CC3)cc2)nc2c1CN(C(=O)C1CC1)C2",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCC(O)(/C=C/c1ccc(C(CC)(CC)c2cc(C)c(B3OC(C)(C)C(C)(C)O3)c(C)c2)cc1C)CC.COC(=O)Cc1ccc(Br)cc1.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1ccccc1.O.O=P([O-])([O-])[O-].[Cl-].[K+].[K+].[K+].[NH4+].[Pd+2]>>CCC(O)(/C=C/c1ccc(C(CC)(CC)c2cc(C)c(-c3ccc(CC(=O)OC)cc3)c(C)c2)cc1C)CC",
        "output": "933"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)C1=Cc2cc(Cl)c(Oc3ccc(CC)cc3)cc2OC1C(F)(F)F.CO.Cl.O.[Li+].[OH-]>>CCc1ccc(Oc2cc3c(cc2Cl)C=C(C(=O)O)C(C(F)(F)F)O3)cc1",
        "output": "122"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.COc1ccccc1COCCCOc1ccc(N2C(=O)CN(C(=O)OC(C)(C)C)C[C@@H]2CO)cc1.ClCCl.O=C(Cl)c1ccc2ccccc2c1>>COc1ccccc1COCCCOc1ccc(N2C(=O)CN(C(=O)OC(C)(C)C)C[C@@H]2COC(=O)c2ccc3ccccc3c2)cc1",
        "output": "51"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1=C(N2C=CC3(CCN(C(=O)OC(C)(C)C)CC3)C2=O)COC1=O.O=C(O)C(F)(F)F>>CC1=C(N2C=CC3(CCNCC3)C2=O)COC1=O",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].Cc1ccccc1.O=C(O)Cc1ccc(O)cc1.Oc1cccc(O)c1.[Na+]>>O=C(Cc1ccc(O)cc1)c1ccc(O)cc1O",
        "output": "435"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCOc1c(-c2cccc3sc(C=C(F)C(=O)OCC)cc23)cc(C(C)C)cc1C(C)C.CO.[Li+].[OH-]>>CCCOc1c(-c2cccc3sc(/C=C(/F)C(=O)O)cc23)cc(C(C)C)cc1C(C)C",
        "output": "122"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCC(Sc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)C(=O)O.CCN(CC)CC.Cc1cccc(C)c1N.O=C(Cl)C(=O)Cl.c1ccccc1>>CCCC(Sc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)C(=O)Nc1c(C)cccc1C",
        "output": "365"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.ClCCl.N#CC1=C(O)C2C(c3ccc(CO)cc3)=CSC2NC1=O.O=[Ru](=O)(=O)[O-]>>N#CC1=C(O)C2C(c3ccc(C=O)cc3)=CSC2NC1=O",
        "output": "179"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(C)=O.CCCCCCI.O.O=C([O-])[O-].O=[N+]([O-])c1cccc(O)c1.[K+].[K+]>>CCCCCCOc1cccc([N+](=O)[O-])c1",
        "output": "198"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOCC.N#CCC1C=CC=CC=C1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCCC1C=CC=CC=C1",
        "output": "246"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)C(CN1CCC(NC(=O)OC(C)(C)C)CC1)c1cccc2ccc(OC)nc12.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>COc1ccc2cccc(C(CO)CN3CCC(NC(=O)OC(C)(C)C)CC3)c2n1",
        "output": "343"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)Cn1ncc2ccccc21.N>>NC(=O)Cn1ncc2ccccc21",
        "output": "432"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.CCN1CCOCC1.CN(C)C=O.ClCCCl.N#Cc1cc(-c2nc(-c3ccc4c(c3)CCNCC4)no2)ccc1N1CCC(F)C1.On1nnc2ccccc21>>CC(C)(C)OC(=O)NCC(=O)N1CCc2ccc(-c3noc(-c4ccc(N5CCC(F)C5)c(C#N)c4)n3)cc2CC1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(S(=O)(=O)Cl)c3)n2)n1.Cl.OC1CNC1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(S(=O)(=O)N4CC(O)C4)c3)n2)n1",
        "output": "99"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#Cc1cccnc1N.C1CCOC1.CCN(CC)CC.ON=C(Cl)Cc1ccc(CCc2ccco2)cc1>>Nc1ncccc1-c1cc(Cc2ccc(CCc3ccco3)cc2)no1",
        "output": "976"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)C[AlH]CC(C)C.COC(=O)c1ccc(-c2ncc(-c3ccccc3)o2)cc1.ClCCl.O=C([O-])C(O)C(O)C(=O)[O-].[K+].[Na+]>>OCc1ccc(-c2ncc(-c3ccccc3)o2)cc1",
        "output": "444"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.N#Cc1cnc2ccc([N+](=O)[O-])cc2c1Nc1ccc2[nH]ccc2c1.NN.[Pd]>>N#Cc1cnc2ccc(N)cc2c1Nc1ccc2[nH]ccc2c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.ClCCOc1cccc2c1c1cccc3c1n2C(c1ccccc1)CO3.NCCO.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>OCCNCCOc1cccc2c1c1cccc3c1n2C(c1ccccc1)CO3",
        "output": "279"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=Cc1ccc(C(F)(F)F)nc1.CN1CCCC1=O.Cc1ccc2[nH]c3c(c2c1)CN(C)C1(CC1)C3.[K+].[OH-]>>Cc1ccc2c(c1)c1c(n2CCc2ccc(C(F)(F)F)nc2)CC2(CC2)N(C)C1",
        "output": "986"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CC(N)=O.CCN(CC)c1ccc2c(c1)N(C(=O)c1ccc(N(C)C)cc1)[C@@H](C)C[C@H]2N(C(C)=O)c1ccc(Cl)cc1.CCNCC>>CCN(CC)c1ccc(N(C(C)=O)[C@@H]2C[C@H](C)N(C(=O)c3ccc(N(C)C)cc3)c3cc(N(CC)CC)ccc32)cc1",
        "output": "105"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)c1nc(-c2cccc(N)c2F)c(-c2ccncn2)s1.CC(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Cl)n2)s1.O=S(=O)(Cl)c1cccc(F)c1>>CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3cccc(F)c3)c2F)c(-c2ccncn2)s1",
        "output": "68"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)O.CC(C)(C)[O-].CN1CCNCC1.O=c1c2cc(Br)ccc2cc(Br)c2ccccc12.O=c1c2ccccc2cc(Br)c2ccc(Br)cc12.[K+]>>CN1CCN(c2cc3ccccc3c(=O)c3cc(Br)ccc23)CC1",
        "output": "294"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Cl.O=C(Cl)c1cccc(F)c1.c1ccc(-c2noc(C3CCCNC3)n2)cc1>>O=C(c1cccc(F)c1)N1CCCC(c2nc(-c3ccccc3)no2)C1",
        "output": "201"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClCCl.Nc1cc(Cl)cc(Cl)c1.O=C([O-])O.S=C(Cl)Cl.[Na+]>>S=C=Nc1cc(Cl)cc(Cl)c1",
        "output": "114"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=CCCC(C)CCOC(=O)C=Cc1ccccc1O.CC/C=C\\CCOC(=O)Cl.c1ccncc1>>CCC=CCCOC(=O)Oc1ccccc1C=CC(=O)OCCC(C)CCC=C(C)C",
        "output": "261"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCO.CCOc1cc(C=O)ccc1OC.CCc1cnc(NC2CCNCC2)nc1.[BH3-]C#N.[Na+]>>CCOc1cc(CN2CCC(Nc3ncc(CC)cn3)CC2)ccc1OC",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C[C@@]1(c2ccc3cc(O)ccc3c2)COC(=O)N1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>C[C@@]1(c2ccc3cc(OS(=O)(=O)C(F)(F)F)ccc3c2)COC(=O)N1",
        "output": "731"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN=C=O.ClCCl.Nc1ccc2c(c1)C(CN1CCC(n3ccc4cc(Cl)ccc43)CC1)CC2>>CNC(=O)Nc1ccc2c(c1)C(CN1CCC(n3ccc4cc(Cl)ccc43)CC1)CC2",
        "output": "176"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCCCCCCCBr.OCCCc1ccccc1>>BrCCCCCCCOCCCc1ccccc1",
        "output": "95"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1ccnc(-c2ccc(OC(F)(F)F)cc2)n1.CO.[BH4-].[Li+]>>OCc1ccnc(-c2ccc(OC(F)(F)F)cc2)n1",
        "output": "711"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)c1nn(-c2cc(C(C)(C)C)nc(C(C)(C)C)c2)c(CC2CCCCC2)c1Cl.O.O.[Li]O>>CC(C)(C)c1cc(-n2nc(C(=O)O)c(Cl)c2CC2CCCCC2)cc(C(C)(C)C)n1",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1cc(NS(C)(=O)=O)cc([N+](=O)[O-])c1>>COC(=O)c1cc(N)cc(NS(C)(=O)=O)c1",
        "output": "481"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#C[Si](C)(C)C.CCOCC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Nc1ccc(I)cc1F.[Cu]I>>C[Si](C)(C)C#Cc1ccc(N)c(F)c1",
        "output": "826"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC1)N=C(c1ccccc1)NC2=O.ClCCl.O=C(O)C(F)(F)F>>O=C1NC(c2ccccc2)=NC12CCNCC2",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Clc1cc(Nc2cc(C3CC3)[nH]n2)nc(N2CCCC2c2cc(-c3ccccn3)no2)n1.OCCO.[H-].[Na+]>>OCCOc1cc(Nc2cc(C3CC3)[nH]n2)nc(N2CCCC2c2cc(-c3ccccn3)no2)n1",
        "output": "653"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)c1ccncc1.CS(=O)(=O)Cl.CSc1nc(Cl)c(CCO)c(NC2CC(F)(F)C2)n1.ClCCl>>CSc1nc(Cl)c(CCOS(C)(=O)=O)c(NC2CC(F)(F)C2)n1",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.COCCN(C)c1ccc(NC(=O)Oc2ccccc2)cn1.Cl.ClCCl.NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1>>COCCN(C)c1ccc(NC(=O)NCc2cc(C(F)(F)F)nn2-c2cccc(Cl)c2)cn1",
        "output": "488"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cl.Cl.Nc1c(F)c(N)c(F)c(F)c1F.O=C(C(CCBr)c1ccccc1)N1C2CCCC1CC2.[I-].[K+].c1ccc(N2CCNCC2)nc1>>O=C(C(CCN1CCN(c2ccccn2)CC1)c1ccccc1)N1C2CCCC1CC2",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N(C)C.O=C(NCc1ccc(Cl)cc1Cl)c1ccc(F)nc1.OCCN1CCOCC1.[H-].[Na+]>>O=C(NCc1ccc(Cl)cc1Cl)c1ccc(OCCN2CCOCC2)nc1",
        "output": "541"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCOC(=O)[C@H]1CNC[C@@H]1C(=O)Nc1ccc(Cl)cc1.CS(=O)(=O)Cl.Cl>>CCOC(=O)[C@H]1CN(S(C)(=O)=O)C[C@@H]1C(=O)Nc1ccc(Cl)cc1",
        "output": "584"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCc1cnc(-c2ccc(O)cc2)nc1.FC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)OC(F)(F)COCCCCCCBr>>CCCCCCCCc1cnc(-c2ccc(OCCCCCCOCC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)OC(F)(F)F)cc2)nc1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(SCc3ccc(C(=O)O)cn3)c2CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCc1ccc(C(F)(F)F)cc1F.O>>CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(SCc3ccc(C(=O)NCc4ccc(C(F)(F)F)cc4F)cn3)c2CC1",
        "output": "790"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C(OCc1ccccc1)N(CCCO)c1cccc[n+]1[O-]>>CS(=O)(=O)OCCCN(C(=O)OCc1ccccc1)c1cccc[n+]1[O-]",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "N.O=C(O)c1c(C(F)(F)F)ccc(Cl)c1Cl.O=S(Cl)Cl.c1ccccc1.c1ccncc1>>NC(=O)c1c(C(F)(F)F)ccc(Cl)c1Cl",
        "output": "358"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCNCC1.O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](c2ccc(Cl)cc2)[C@H](c2ccccc2)C1.c1ccc(-c2ccccc2P(C2CCCCC2)C2CCCCC2)cc1>>CN1CCN(c2ccc([C@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@H]3c3ccccc3)cc2)CC1",
        "output": "105"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(C)=O.Cc1cc(F)ccc1-c1cc(Cl)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.O.O=C([O-])[O-].O[C@H]1CCN2CCNCC12.[K+].[K+]>>Cc1cc(F)ccc1-c1cc(N2CCN3CC[C@H](O)C3C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CS(=O)(=O)OCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1CCCn2c1cc(Cl)nc2=O.N#Cc1cc(CO)ccc1Oc1ccc(C(F)(F)F)cc1>>CN1CCCn2c1cc(OCc1ccc(Oc3ccc(C(F)(F)F)cc3)c(C#N)c1)nc2=O",
        "output": "653"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCC(=O)O.COc1cc(OC[C@H]2C[C@H](O)CN2)c2c(Nc3ccc(F)c(Cl)c3)ncnc2c1>>COCC(=O)N1C[C@@H](O)C[C@@H]1COc1cc(OC)cc2ncnc(Nc3ccc(F)c(Cl)c3)c12",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CC(=O)c1ccccc1N.CC(Cl)Cl>>CC(=O)Nc1ccccc1C(C)=O",
        "output": "9"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)c1cc(-c2ccn(C)c2)n(-c2cccnc2)n1.[Na+].[OH-]>>Cn1ccc(-c2cc(C(=O)O)nn2-c2cccnc2)c1",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1=COCCC1.ClCCl.O=C1N=C(N[C@H]2C[C@@H]3CC[C@H]2C3)SC1CCO>>O=C1N=C(N[C@H]2C[C@@H]3CC[C@H]2C3)SC1CCOC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.COC(=O)C(=O)Nc1cccc(CO)c1.[Mn+4].[O-2].[O-2]>>COC(=O)C(=O)Nc1cccc(C=O)c1",
        "output": "179"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)NS(=O)(=O)c1ccc(-c2nc(Nc3cc(C4CC4)n[nH]3)cc(C3CC3)n2)s1.O=C(O)C(F)(F)F>>NS(=O)(=O)c1ccc(-c2nc(Nc3cc(C4CC4)n[nH]3)cc(C3CC3)n2)s1",
        "output": "680"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(CCCN4CC(C#N)C4)c4ccc(OC(F)F)cc34)nc12.ClCCl.O=C(O)C(F)(F)F>>CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3nn(CCCN4CC(C#N)C4)c4ccc(OC(F)F)cc34)nc12",
        "output": "981"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#Cc1cc(OCc2ccccc2)c(OCc2ccccc2)nn1.C1=NCCCN(C2CCCCCCCCCC2)CCCCC1.C1CCOC1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.FC(F)(F)c1ccc(I)cn1.[Cu]I>>FC(F)(F)c1ccc(C#Cc2cc(OCc3ccccc3)c(OCc3ccccc3)nn2)cn1",
        "output": "819"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.Cc1c(CO)cccc1-c1ccc2c(c1)OCCO2.O=Cc1cc(Cl)c(O)cc1O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1c(COc2cc(O)c(C=O)cc2Cl)cccc1-c1ccc2c(c1)OCCO2",
        "output": "347"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NCCc1ccc(O)cc1.ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CC(C)(C)OC(=O)NCCc1ccc(OS(=O)(=O)C(F)(F)F)cc1",
        "output": "731"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)c1ccc(Cl)cc1.CC(C)O>>CC(O)c1ccc(Cl)cc1",
        "output": "24"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCc1ccc(C2CC(C(=O)O)CN(C(=O)N3CCOCC3)C2)cc1.N=C(NO)c1cccc(C(F)(F)F)c1>>CCc1ccc(C2CC(c3nc(-c4cccc(C(F)(F)F)c4)no3)CN(C(=O)N3CCOCC3)C2)cc1",
        "output": "895"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@@H]32)C1.CCO.O.[BH4-].[Na+]>>CC(=O)OC1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CCC(O)[C@@]4(C)CC[C@@H]32)C1",
        "output": "91"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)c1ccc(OCC(=O)O)cc1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CS(=O)(=O)Nc1ccc(CN)cc1F.Cl.Cl>>CC(C)(C)c1ccc(OCC(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1",
        "output": "599"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.CCCc1cc(OC)c(C(=O)c2ccccc2)cc1OC.ClCCl.O>>CCCc1cc(O)c(C(=O)c2ccccc2)cc1O",
        "output": "20"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[O-].CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1cc(Br)nc(C)c1NC(=O)CC(C)(C)C.Cc1ccccc1.[K+].c1ncc2c(n1)CCNC2>>Cc1cc(N2CCc3ncncc3C2)nc(C)c1NC(=O)CC(C)(C)C",
        "output": "647"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)OC(C)C.CCOC(C)=O.CO.C[O-].O.O=C1CC(C=C(F)F)CN1Cc1c(C(F)(F)F)nc2ccc(Cl)nn12.[Na+]>>COc1ccc2nc(C(F)(F)F)c(CN3CC(C=C(F)F)CC3=O)n2n1",
        "output": "407"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)c1ccc(CBr)cc1.O=C(c1ccccc1)c1cnc2c(C(F)(F)F)cccc2c1-c1cccc(O)c1>>CC(C)c1ccc(COc2cccc(-c3c(C(=O)c4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)cc1",
        "output": "127"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1cccc(CN2CCC(Nc3ncnc4ccc(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)cc34)CC2)c1.Cl.[Na+].[OH-]>>O=C(O)c1cccc(CN2CCC(Nc3ncnc4ccc(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)cc34)CC2)c1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)c1cc(=O)[nH]c2ccccc12.Cc1ccccc1.O=P(Cl)(Cl)Cl>>COC(=O)c1cc(Cl)nc2ccccc12",
        "output": "100"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)Oc1ccc(C(=O)O)cc1OC.O=S(Cl)Cl>>COC(=O)Oc1ccc(C(=O)Cl)cc1OC",
        "output": "3"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COCCI.[H-].[Na+].c1ccc2[nH]ccc2c1>>COCCn1ccc2ccccc21",
        "output": "302"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)C1=NNC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1.[K+].[OH-]>>CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)O)=NN1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)c1nc(N2CCN[C@H](C)C2)c(C#N)cc1Br.CCN(CC)CC.COc1ccc(CCl)cc1>>COc1ccc(CN2CCN(c3nc(C(C)C)c(Br)cc3C#N)C[C@H]2C)cc1",
        "output": "156"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O=C(O)CNc1ccc(O)cc1>>COC(=O)CNc1ccc(O)cc1",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)Cc1cn(C(N)=O)c2ccccc12.CO.O.[Na+].[OH-]>>NC(=O)n1cc(CC(=O)O)c2ccccc21",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#CCO.C1CCOC1.CCN(C(C)C)C(C)C.ClC(Cl)Cl.Clc1cc(Cl)cc(I)c1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Cl-].[Cu]I.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>OCC#Cc1cc(Cl)cc(Cl)c1",
        "output": "664"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CNC(=O)c1c(-c2ccc(F)cc2)oc2nc(N(C)S(C)(=O)=O)c(C(C)=O)cc12.[BH4-]>>CNC(=O)c1c(-c2ccc(F)cc2)oc2nc(N(C)S(C)(=O)=O)c(C(C)O)cc12",
        "output": "449"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COCCOc1ccc(C#CC2(O)CN3CCC2CC3)cc1.[H][H].[Pd]>>COCCOc1ccc(CCC2(O)CN3CCC2CC3)cc1",
        "output": "717"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC1=C(OC)C(=O)C(Cc2ccc(CCC(=O)O)cc2)=C(C)C1=O.NCc1ccccc1>>COC1=C(OC)C(=O)C(Cc2ccc(CCC(=O)NCc3ccccc3)cc2)=C(C)C1=O",
        "output": "599"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cn1ccnc1Cn1c(C(=O)O)cc2ccccc21.F[P-](F)(F)(F)(F)F.NCC1(c2cccnc2)CCCCC1.O>>Cn1ccnc1Cn1c(C(=O)NCC2(c3cccnc3)CCCCC2)cc2ccccc21",
        "output": "137"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.FC(F)(F)Cc1nc2cc(Cl)c(Cl)cc2[nH]1.FC(F)(F)c1ccccc1CBr.O=C([O-])[O-].[K+].[K+]>>FC(F)(F)Cc1nc2cc(Cl)c(Cl)cc2n1Cc1ccccc1C(F)(F)F",
        "output": "658"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCc1cccc(C(=O)O)c1.CO.O.O=S(=O)(O)O>>CCc1cccc(C(=O)OC)c1",
        "output": "33"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CCCC[C@H]1C.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>C[C@@H]1CCCC[C@@H]1Nc1c(CO)cnc2[nH]ccc12",
        "output": "383"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CNC1.O=C(O)Cc1ccc(S(=O)(=O)Cl)cc1>>O=C(O)Cc1ccc(S(=O)(=O)N2CCC2)cc1",
        "output": "99"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCCCCCCCC(=O)O.O=C(Cl)CCl.Oc1ccccc1>>CCCCCCCCC(=O)Oc1ccccc1",
        "output": "108"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Br.CO.Cc1ccccc1.ClCCl.NCCBr.Nc1cccc(F)c1>>NCCNc1cccc(F)c1",
        "output": "273"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.CN(C)C=O.O.O=C([O-])[O-].O=Cc1cc(Br)ccc1F.[K+].[K+]>>O=Cc1cc(Br)ccc1N1CCCC1",
        "output": "868"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC#N.CC(=O)[O-].CC(=O)c1cc(Cl)c2cccnc2c1N1CCN(C(=O)C2CC2)CC1.CO.[BH3-]C#N.[NH4+].[Na+]>>CC(N)c1cc(Cl)c2cccnc2c1N1CCN(C(=O)C2CC2)CC1",
        "output": "552"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1ccc([N+](=O)[O-])cc1O.O=C=Nc1cccc(Br)c1>>O=C(Nc1cccc(Br)c1)Nc1ccc([N+](=O)[O-])cc1O",
        "output": "473"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.Cc1cccc(C#CC2(O)CCCC3CN(C(=O)OC(C)(C)C)CC32)c1.Cl>>Cc1cccc(C#CC2(O)CCCC3CNCC32)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCc1cc2cc(OC)c(Cl)c(Cl)c2s1.Cl.O.c1ccncc1>>CCCCc1cc2cc(O)c(Cl)c(Cl)c2s1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCc1nc2c(F)ccc(O[C@@H](C)C(=O)OC)c2c(OC(F)F)c1Cc1ccc(C(=O)N2CCCC2)cc1Cl.O.[Li+].[OH-]>>CCc1nc2c(F)ccc(O[C@@H](C)C(=O)O)c2c(OC(F)F)c1Cc1ccc(C(=O)N2CCCC2)cc1Cl",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.O=C([O-])[O-].O=c1[nH]cc(-c2ccccc2)c2ccccc12.OCCCCl.[K+].[K+]>>O=c1c2ccccc2c(-c2ccccc2)cn1CCCO",
        "output": "42"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(Cc1cccc(CCC(=O)O)c1)NC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(O)c(CO)c1.NCc1ccc(Cl)c(Cl)c1>>CC(C)(Cc1cccc(CCC(=O)NCc2ccc(Cl)c(Cl)c2)c1)NC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(O)c(CO)c1",
        "output": "599"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC1(C(=O)Nc2ccc(Br)cc2)CCCC1.CCCC[N+](CCCC)(CCCC)CCCC.CSc1ccccc1B(O)O.Cc1ccccc1.O.O=C([O-])[O-].[Br-].[Na+].[Na+]>>CSc1ccccc1-c1ccc(NC(=O)C2(NC(=O)OC(C)(C)C)CCCC2)cc1",
        "output": "837"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)O.CCOC(=O)C(C)Oc1ccc(Oc2cnc3cc(Cl)ccc3n2)cc1F.O.[Na+].[OH-]>>CC(Oc1ccc(Oc2cnc3cc(Cl)ccc3n2)cc1F)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)CNCc1ccc(C#N)cc1.CCN(CC)CC.ClCCl>>CC(C)CN(Cc1ccc(C#N)cc1)C(=O)OC(C)(C)C",
        "output": "867"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)n1nc([N+](=O)[O-])cc1C1CC1.CCO.[Pd]>>CC(C)(C)OC(=O)n1nc(N)cc1C1CC1",
        "output": "684"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCN(CC1CCNCC1)c1ncnc2c1cnn2-c1ccc(S(C)(=O)=O)cc1F.CN(C)C=O.Cl.FC(F)(F)c1ccc(Br)nc1>>CCN(CC1CCN(c2ccc(C(F)(F)F)cn2)CC1)c1ncnc2c1cnn2-c1ccc(S(C)(=O)=O)cc1F",
        "output": "647"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.ClCCCSc1ccccc1.OCCNCCO.[I-].[Na+]>>OCCN(CCO)CCCSc1ccccc1",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CC(C)C1=CCC(C)(C)c2cc(O)c(Br)cc21.CCCI.O=C([O-])[O-].[K+].[K+]>>CCCOc1cc2c(cc1Br)C(C(C)C)=CCC2(C)C",
        "output": "198"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCCC(O)C1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.c1ccncc1>>Cc1ccc(S(=O)(=O)OC2CCCN(C(=O)OC(C)(C)C)C2)cc1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)c1cc2cc(-c3cccnc3)ccc2s1.O.O.[Li+].[OH-]>>O=C(O)c1cc2cc(-c3cccnc3)ccc2s1",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1CC(CNC(=O)OC(C)(C)C)CCN1.ClCCl.O=C(Cl)OCc1cc(Cl)cc(Cl)c1.O=C([O-])O.[Na+]>>CC1CC(CNC(=O)OC(C)(C)C)CCN1C(=O)OCc1cc(Cl)cc(Cl)c1",
        "output": "427"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CC(C)(C)[Si](OCc1ccc(CCCC2OCCO2)cc1)(c1ccccc1)c1ccccc1.Cl.O=C([O-])[O-].[K+].[K+].c1c[nH]cn1>>CC(C)(C)[Si](OCc1ccc(CCCC=O)cc1)(c1ccccc1)c1ccccc1",
        "output": "740"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)NCc1ccc(Oc2ccc3c(c2)COB3O)cc1.Cl.ClCCl>>NC(Cc1ccccc1)C(=O)NCc1ccc(Oc2ccc3c(c2)COB3O)cc1",
        "output": "431"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.Cc1ccc(C)c2c1c1cc(Br)ccc1n2C(C)C.O.O=[N+]([O-])O>>Cc1c([N+](=O)[O-])cc(C)c2c1c1cc(Br)ccc1n2C(C)C",
        "output": "21"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.CCOC(C)=O.C[C@H](CO)CBr.O.c1ccncc1>>CC(=O)OC[C@@H](C)CBr",
        "output": "254"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)CCCl.Cl.NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1NCC(c1cccc(O)c1)C2>>CN(C)CCOc1cccc(C2CNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn3C2)c1",
        "output": "74"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(Cc1nc(-c2cccc(C(=O)OC)c2)oc1C)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1.CCOCC.Cl.O.[Li+].[OH-]>>CCN(Cc1nc(-c2cccc(C(=O)O)c2)oc1C)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1c(O)ccc(C(C)=O)c1O.N#Cc1cncc(Sc2cccc(CO)c2)c1>>CCCc1c(OCc2cccc(Sc3cncc(C#N)c3)c2)ccc(C(C)=O)c1O",
        "output": "347"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOCC.Nc1ccc(NNC(=O)c2ccccc2)cc1.S=C=Nc1ccccc1>>O=C(NNc1ccc(NC(=S)Nc2ccccc2)cc1)c1ccccc1",
        "output": "474"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.FC(F)(F)c1ccccc1OC1CCNCC1.O.O=C(O)C(F)(F)F.O=C(O)CNC(=O)c1cc(-c2ccccc2)[nH]n1.On1nnc2ccccc21>>O=C(NCC(=O)N1CCC(Oc2ccccc2C(F)(F)F)CC1)c1cc(-c2ccccc2)[nH]n1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.O=C([O-])[O-].O=C1CCc2cc(F)ccc21.OCC(F)(F)C(F)(F)F.[K+].[K+]>>O=C1CCc2cc(OCC(F)(F)C(F)(F)F)ccc21",
        "output": "485"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCN(CC)CC.CN(C)C=O.COC(=O)[C@H](CNC(=O)c1ccc2c(cnn2Cc2cc(=O)[nH]c(N)n2)c1)NS(=O)(=O)c1cccc2ccccc12.O.On1nnc2ccccc21>>Nc1nc(Cn2ncc3cc(C(=O)NC[C@H](NS(=O)(=O)c4cccc5ccccc45)C(=O)O)ccc32)cc(=O)[nH]1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1ccccc1Nc1cccc(-c2ccc3ccccc3c2)n1.O.[Li+].[OH-]>>O=C(O)c1ccccc1Nc1cccc(-c2ccc3ccccc3c2)n1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)C(C)(C)c1ccc(-c2ccc(CCc3cn(Cc4ccccc4)nn3)cc2)cc1.CCOC(=O)C(C)(C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.O.O.[Li+].[OH-]>>CC(C)(C(=O)O)c1ccc(-c2ccc(CCc3cn(Cc4ccccc4)nn3)cc2)cc1",
        "output": "615"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCCCCCCCCCCCOCC1CO1.CCO.COCCCN>>CCCCCCCCCCCCCCCCOCC(O)CNCCCOC",
        "output": "16"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C1CCOC1.CC1(C)CNC(=O)c2cc3ccc(C(=O)O)cc3n21.CN(C)C=O.Cc1cccc(C)n1.ClCCl.Nc1nccs1.O=C(Cl)C(=O)Cl>>CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4nccs4)cc3n21",
        "output": "918"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1cc2cccc(NS(=O)(=O)c3ccccn3)c2n1COC.CO.O=C(O)CC(O)(CC(=O)O)C(=O)O.[K+].[OH-]>>COCn1c(C(=O)O)cc2cccc(NS(=O)(=O)c3ccccn3)c21",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCCNCC1.CN(C)C=O.O.O=C([O-])[O-].O=Cc1cc(Br)ccc1F.[K+].[K+]>>O=Cc1cc(Br)ccc1N1CCCCCC1",
        "output": "868"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrBr.C1CCOC1.CC(=O)c1ccc2c(c1)COC(C)(C)O2.COC(C)(C)C.C[Si](C)(C)Cl.C[Si](C)(C)[N-][Si](C)(C)C.[Na+]>>CC1(C)OCc2cc(C(=O)CBr)ccc2O1",
        "output": "173"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.CCOC(=O)CC(O)C(C)Oc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1.c1ccccc1.c1ccncc1>>CCOC(=O)CC(OC(C)=O)C(C)Oc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1",
        "output": "126"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(C)C(C)C(=O)Cl.CCOC(=O)c1cnc2c3cc(N)ccc3c(C)cn2c1=O.c1ccncc1>>CCOC(=O)c1cnc2c3cc(NC(=O)C(C)C(C)CC)ccc3c(C)cn2c1=O",
        "output": "9"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "N#CCc1ccc(O)c(C=O)c1.O=C1CCC(=O)N1Br>>N#CCc1cc(Br)c(O)c(C=O)c1",
        "output": "4"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCCCCBr.O.OCCCc1ncccc1OCc1ccccc1.[Na+].[OH-]>>BrCCCCCCOCCCc1ncccc1OCc1ccccc1",
        "output": "95"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)CN(CC(C)C)c1ccc(Br)cc1N.CCN(CC)CC.CCOCC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cc1ccc(CC(=O)O)cc1.F[P-](F)(F)(F)(F)F>>Cc1ccc(CC(=O)Nc2cc(Br)ccc2N(CC(C)C)CC(C)C)cc1",
        "output": "365"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.NC1CCCCC1.O=C(Cl)c1ccc(Br)cc1>>O=C(NC1CCCCC1)c1ccc(Br)cc1",
        "output": "271"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1ccc(-c2cccc(F)c2)c([N+](=O)[O-])c1.CCO.CCOC(C)=O.[Pd]>>CC(C)(C)c1ccc(-c2cccc(F)c2)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)c1cc(C)c2[nH]c(=O)oc2c1.Cl.O.[Na+].[OH-]>>Cc1cc(C(=O)O)cc2oc(=O)[nH]c12",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.FC(F)(F)c1c(OCc2ccccc2)ccn2c(CC3CC3)nnc12.[Pd]>>Oc1ccn2c(CC3CC3)nnc2c1C(F)(F)F",
        "output": "23"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O=C(O)Cn1c(-c2cccs2)n[nH]c1=S.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCn1c(-c2cccs2)n[nH]c1=S",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.ClCCNCCCl.Clc1ccccc1Cl.Nc1ccccc1C1=CCCCCCC1>>C1=C(c2ccccc2N2CCNCC2)CCCCCC1",
        "output": "640"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)c1ccc2c(c1)nc(-c1c(Cl)cccc1Cl)n2C.[Na+].[OH-]>>Cn1c(-c2c(Cl)cccc2Cl)nc2cc(C(=O)O)ccc21",
        "output": "5"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)NC(=O)Cc1cccc(N)c1.CC(C)=O.CCN(CC)CC.COC(=O)Cl>>COC(=O)Nc1cccc(CC(=O)NC(C)(C)C)c1",
        "output": "102"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)CN.CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)NCC(=O)OC(C)(C)C.CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)O.COc1ccc(Cl)cc1CC1CNC(=O)CN(S(=O)(=O)c2ccc(Cl)c(C(=O)O)c2)C1=O.Cl.Nc1ccccc1>>COc1ccc(Cl)cc1CC1CNC(=O)CN(S(=O)(=O)c2ccc(Cl)c(C(=O)Nc3ccccc3)c2)C1=O",
        "output": "50"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COCCN.COc1cc([N+](=O)[O-])ccc1Cl>>COCCNc1ccc([N+](=O)[O-])cc1OC",
        "output": "304"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=Cc1ccc(OC(C)=O)cc1.CO.COCC(C)O.Cl.O>>C=Cc1ccc(O)cc1",
        "output": "22"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1[C@H](N)CCN1[C@H](CO)c1ccccc1.CCN(CC)CC>>CC1[C@H](NC(=O)OC(C)(C)C)CCN1[C@H](CO)c1ccccc1",
        "output": "631"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](OCCCCl)C[C@]4(C)[C@H]3C(=O)C[C@]12C.CCOCC.Cc1ccc(S(=O)(=O)O)cc1.O=C([O-])O.OCCO.[Na+].c1ccccc1>>CC1([C@H]2CC[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](OCCCCl)C[C@]5(C)[C@H]4C(=O)C[C@@]32C)OCCO1",
        "output": "265"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CC(C)(C)c1ccc(CC(O)CC2CCCCC2)cc1[N+](=O)[O-].CCN(CC)CC.CN(C)C=O.CN(C)c1ccncc1.O>>CC(C)(C)c1ccc(CC(CC2CCCCC2)O[Si](C)(C)C(C)(C)C)cc1[N+](=O)[O-]",
        "output": "193"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)CCn1ccnc1CCC(=O)O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)[C@H]1CCNC1.ClCCl.F[P-](F)(F)(F)(F)F>>CCOC(=O)CCn1ccnc1CCC(=O)N1CC[C@H](N(C)C)C1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.NC1CCOCC1.O.O=[N+]([O-])c1ccc(Br)cc1F>>O=[N+]([O-])c1ccc(Br)cc1NC1CCOCC1",
        "output": "572"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)N1CC=C(C(C)(C)c2ccc([N+](=O)[O-])cc2)CC1.[Pd]>>CCOC(=O)N1CC=C(C(C)(C)c2ccc(N)cc2)CC1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCN(CCC)C(=O)c1cc(Br)cc(C(=O)OC)c1.CO.O.O.[Li+].[OH-]>>CCCN(CCC)C(=O)c1cc(Br)cc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOCC.Cc1ncc(-c2ccnc(NC3CCN(C(=O)OCc4ccccc4)CC3)n2)n1C(C)C.[Pd]>>Cc1ncc(-c2ccnc(NC3CCNCC3)n2)n1C(C)C",
        "output": "428"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.O=[N+]([O-])c1c(NCc2ccccc2)cc(-c2ncco2)nc1NCc1ccccc1.[Ni]>>Nc1c(NCc2ccccc2)cc(-c2ncco2)nc1NCc1ccccc1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.COc1ccc(S(=O)(=O)C(C)(F)C2CCNCC2)cn1.CS(C)=O.Cl.O=C(Nc1ccnnc1)Oc1ccccc1>>COc1ccc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3ccnnc3)CC2)cn1",
        "output": "525"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=O.CC#N.CCCCCCC.CCN(CC)CC.CCOC(C)=O.CO.Cc1ccccc1CC#N.Cl.Oc1cccc(Br)c1.[Cl-].[Cl-].[Mg+2]>>O=Cc1ccc(Br)cc1O",
        "output": "451"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NC(=O)NCCNc1ccc([N+](=O)[O-])cc1.O=S([O-])S(=O)[O-].[Na+].[OH-]>>NC(=O)NCCNc1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)[C@H]1CCN[C@@H](C)C1>>COC(=O)[C@H]1CCN(C(=O)OC(C)(C)C)[C@@H](C)C1",
        "output": "694"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(F)ccc1S(=O)(=O)Cl.N#Cc1ccc(-c2cncc(N)c2)cc1Cl.c1ccncc1>>Cc1cc(F)ccc1S(=O)(=O)Nc1cncc(-c2ccc(C#N)c(Cl)c2)c1",
        "output": "554"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)O.Cc1cc(C)cc(I)c1.O=C([O-])[O-].OCCO.Sc1ccccc1Cl.[Cu]I.[K+].[K+]>>Cc1cc(C)cc(Sc2ccccc2Cl)c1",
        "output": "565"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Clc1ccc2cc[nH]c2c1.O=C(N1CCN(c2cc(S(=O)(=O)Cl)ccc2OCC(F)(F)C(F)F)CC1)C(Cl)(Cl)Cl.[H-].[Na+]>>O=C(N1CCN(c2cc(S(=O)(=O)n3ccc4ccc(Cl)cc43)ccc2OCC(F)(F)C(F)F)CC1)C(Cl)(Cl)Cl",
        "output": "648"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)N(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.O=C(O)C(F)(F)F>>CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)N(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.O=C(N1CCC(NCCSc2cccs2)CC1)C(F)(F)F>>CC(C)(C)OC(=O)N(CCSc1cccs1)C1CCN(C(=O)C(F)(F)F)CC1",
        "output": "694"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Nc1ccc(O)cc1[N+](=O)[O-].O=Cc1ccc(F)c(Cl)c1>>Nc1ccc(Oc2ccc(C=O)cc2Cl)cc1[N+](=O)[O-]",
        "output": "564"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCC(Oc1ccc(C(=O)OCC)cc1)c1ccc(-c2ccc(C(F)(F)F)cc2)nc1.CCO.[Na+].[OH-]>>CCCCCCC(Oc1ccc(C(=O)O)cc1)c1ccc(-c2ccc(C(F)(F)F)cc2)nc1",
        "output": "386"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)c1cccc(-n2ncc3c(N)cccc32)c1.Cc1cc(N)c2cn[nH]c2c1.Ic1ccccc1>>Cc1cc(N)c2cnn(-c3ccccc3)c2c1",
        "output": "901"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Nc1nccc(C=O)c1[N+](=O)[O-].[BH4-].[Na+]>>Nc1nccc(CO)c1[N+](=O)[O-]",
        "output": "356"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.Nc1ccc(-c2cnc(CNS(=O)(=O)C(F)(F)F)s2)cc1.O=S(=O)(Cl)c1ccccc1>>O=S(=O)(Nc1ccc(-c2cnc(CNS(=O)(=O)C(F)(F)F)s2)cc1)c1ccccc1",
        "output": "68"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1ccccc1S(=O)(=O)N=C=O.COc1cc(OC)nc(N)n1.ClCCl.O.[Na+].[OH-]>>COC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc1nc(OC)cc(OC)n1",
        "output": "566"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CNc1ncccc1[N+](=O)[O-].N#N.NN.O.[Pd]>>CNc1ncccc1N",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CO.Cc1c(C(N)=O)sc2ncnc(Nc3ccc(F)cc3O[C@@H]3CC[C@@H](N(C)C(=O)OC(C)(C)C)CC3)c12.Cl>>CN[C@@H]1CC[C@@H](Oc2cc(F)ccc2Nc2ncnc3sc(C(N)=O)c(C)c23)CC1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Clc1cc(Cl)nc(Cl)n1.N#Cc1cc(CO)ccc1Oc1cccc(C(F)(F)F)c1.[H-].[Na+]>>N#Cc1cc(COc2cc(Cl)nc(Cl)n2)ccc1Oc1cccc(C(F)(F)F)c1",
        "output": "653"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.ClC(Cl)Cl.Clc1cncc(N2CCNCC2)n1.O=C([O-])[O-].Oc1ccccc1.[K+].[K+]>>c1ccc(Oc2cncc(N3CCNCC3)n2)cc1",
        "output": "210"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=C(C)C(=O)Cl.CCOCC.C[Si](C)(C)O[Si](CCCN)(O[Si](C)(C)C)O[Si](C)(C)C.O.c1ccncc1>>C=C(C)C(=O)NCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C",
        "output": "298"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(O)c1cccc(Br)n1.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(=O)c1cccc(Br)n1",
        "output": "456"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1CN(C)C(=O)c2c(OCc3ccccc3)c3c(=O)n(Cc4ccc(F)cc4)ncc3n21.CO.[OH-].[OH-].[Pd+2]>>CC1CN(C)C(=O)c2c(O)c3c(=O)n(Cc4ccc(F)cc4)ncc3n21",
        "output": "264"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CC1(C)CCC(C)(C)c2cc(C(=O)Nc3cc(F)c(C(=O)O)c(F)c3)c(O)cc21.CCI.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1c(F)cc(NC(=O)c2cc3c(cc2O)C(C)(C)CCC3(C)C)cc1F",
        "output": "196"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)C(C)(C)Cc1cc2cc(OCc3ccc4occc4n3)ccc2n1Cc1ccc(Cl)cc1.[Li+].[OH-]>>CC(C)(Cc1cc2cc(OCc3ccc4occc4n3)ccc2n1Cc1ccc(Cl)cc1)C(=O)O",
        "output": "361"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[O-].CCC(=O)c1cc(Cl)ccc1NS(=O)(=O)C(F)(F)F.CCO.Cl.NOCc1ccc(C(F)(F)F)cc1C(F)(F)F.[Na+]>>CCC(=NOCc1ccc(C(F)(F)F)cc1C(F)(F)F)c1cc(Cl)ccc1NS(=O)(=O)C(F)(F)F",
        "output": "212"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCC(N2CCCCC2=O)CC1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1ccccc1>>CC(C)(C)OC(=O)N1CCC(N2CCCCC2=S)CC1",
        "output": "695"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NCCO[N+](=O)[O-].O=C1NC(C(=O)O)C(c2ccccc2)S1.O=[N+]([O-])O>>O=C1NC(C(=O)NCCO[N+](=O)[O-])C(c2ccccc2)S1",
        "output": "216"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "N.N[C@@H]1C2CC3CC1CN(C3)C2.O=C(O)c1ccc2c(c1)OCO2>>O=C(N[C@@H]1C2CC3CC1CN(C3)C2)c1ccc2c(c1)OCO2",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=O.CC(=O)O.CO.COc1ncc(N2CCOc3ccc(O[C@H]4CCN(C(=O)[C@@H]5CCNC5)C4)cc32)cc1C#N.ClCCl.O=C([O-])O.[BH3-]C#N.[Na+].[Na+]>>COc1ncc(N2CCOc3ccc(O[C@H]4CCN(C(=O)[C@@H]5CCN(C)C5)C4)cc32)cc1C#N",
        "output": "217"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#Cc1cnc2c(C)cc(-c3ccc(C(F)(F)F)cc3)cn12.NS(=O)(=O)c1ccc(Br)s1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)cn2c(C#Cc3ccc(S(N)(=O)=O)s3)cnc12",
        "output": "766"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(-c2ccc(Cl)cc2)c(C(=O)Nc2ccc(N(CCc3cscn3)C(=O)OC(C)(C)C)cc2)c1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(-c2ccc(Cl)cc2)c(C(=O)Nc2ccc(NCCc3cscn3)cc2)c1",
        "output": "830"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.Cl.Nc1ccccc1.O=C1CC(=O)N(c2ccc(C(=O)O)cc2)c2ccc3ccccc3c2N1.On1nnc2ccccc21>>O=C1CC(=O)N(c2ccc(C(=O)Nc3ccccc3)cc2)c2ccc3ccccc3c2N1",
        "output": "50"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(N)CC1.CCN(C(C)C)C(C)C.Clc1nc(Cl)c2cc(Br)ccc2n1.O>>CC(C)(C)OC(=O)N1CCC(Nc2nc(Cl)nc3ccc(Br)cc23)CC1",
        "output": "110"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.O=C(O)c1ccc(-c2cccnc2)cc1.O=S(=O)(O)O.[Na+].[OH-]>>COC(=O)c1ccc(-c2cccnc2)cc1",
        "output": "33"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(Oc1cccc2ccc(-c3nnc4ccccn34)nc12)[C@@H](CC)CNC(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CCC(Oc1cccc2ccc(-c3nnc4ccccn34)nc12)[C@@H](CC)CN",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cnc3ccc(C(=O)c4cc(N)ccc4F)cc3n2)CC1.ClCCl.O=C=Nc1cccc(C(F)(F)F)c1>>CC(C)(C)OC(=O)N1CCN(c2cnc3ccc(C(=O)c4cc(NC(=O)Nc5cccc(C(F)(F)F)c5)ccc4F)cc3n2)CC1",
        "output": "473"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CN(CCCl)c1cc(Br)c(C(F)(F)F)cc1[N+](=O)[O-].[Fe]>>CN(CCCl)c1cc(Br)c(C(F)(F)F)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O.O=P(Cl)(Cl)Cl.O=c1cc(-c2ccccc2)nc(-c2ccc(C(F)(F)F)cc2)[nH]1.[Na+].[OH-]>>FC(F)(F)c1ccc(-c2nc(Cl)cc(-c3ccccc3)n2)cc1",
        "output": "14"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.C[Si](C)(C)[N-][Si](C)(C)C.Cc1ccc(C(C)(C)C)cc1N.Fc1ccc2nc(Cl)c3ccnc(Cl)c3c2c1.[Na+]>>Cc1ccc(C(C)(C)C)cc1Nc1nc2ccc(F)cc2c2c(Cl)nccc12",
        "output": "434"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.CC(=O)c1ccc(F)cc1O.CN(C)C=O.Cl.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1ccc(F)cc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCOC(=O)CBr.CNCCc1c(Cl)cccc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CN(C)CCc1c(Cl)cccc1[N+](=O)[O-]",
        "output": "467"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)OB(c2ccc(-c3nc4c(ncn4-c4cccc(C#N)c4)c(=O)n3-c3ccc(Cl)cc3)cc2)OC1(C)C.CN(C)C=O.Cl[Pd]Cl.Nc1ccc(Br)nc1.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>N#Cc1cccc(-n2cnc3c(=O)n(-c4ccc(Cl)cc4)c(-c4ccc(-c5ccc(N)cn5)cc4)nc32)c1",
        "output": "939"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCN.CCO.CCOC(=O)COc1ccc(C=O)cc1CC>>CCCCNCc1ccc(OCC(=O)OCC)c(CC)c1",
        "output": "468"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1[nH]c(C)c(-c2cccc(C(=O)O)c2)c1C.CCOC(C)=O.ClCCl.Nc1ccc(Br)cc1F.O=C(Cl)C(=O)Cl.O=C([O-])O.[Na+]>>CCOC(=O)c1[nH]c(C)c(-c2cccc(C(=O)Nc3ccc(Br)cc3F)c2)c1C",
        "output": "50"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccccc1.Cl.O=C(Cl)c1cccc(Cl)c1.Oc1ccccc1.c1ccncc1>>O=C(Oc1ccccc1)c1cccc(Cl)c1",
        "output": "482"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.O=C(O)C(Cl)Cl.O=C1CCC(=O)N1I.O=c1cc(O)ccn1Cc1cccc(F)c1>>O=c1c(I)c(O)ccn1Cc1cccc(F)c1",
        "output": "783"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1COc1cnc(Cl)c(-c2ccccc2)c1.CCO.Cl>>Clc1ncc(OC[C@@H]2CCCN2)cc1-c1ccccc1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CN(c1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccccc1[N+](=O)[O-].[Pd]>>CN(c1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccccc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.Cc1ccc(-c2c(CN)c(CC(C)(C)C)nc(C)c2C(=O)O)cc1.Cl.Cl.Cl.O=C(Cl)OCc1ccccc1.[Na+].[OH-]>>Cc1ccc(-c2c(CNC(=O)OCc3ccccc3)c(CC(C)(C)C)nc(C)c2C(=O)O)cc1",
        "output": "479"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)(CN)C(C)(C)c1ccc2c(cnn2-c2ccc(F)cc2)c1.CCN(C(C)C)C(C)C.CO.O=C(Nc1nccs1)Oc1ccccc1.O=C(O)C(F)(F)F>>CC(C)(CNC(=O)Nc1nccs1)C(C)(C)c1ccc2c(cnn2-c2ccc(F)cc2)c1",
        "output": "488"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.NC(=O)C(F)(F)c1ccccc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>N#CC(F)(F)c1ccccc1",
        "output": "172"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)CCc1ccc(Oc2ncnc3oc(-c4ccccc4)c(-c4ccc(OC)cc4)c23)cc1.Cl.[Na+].[OH-]>>COc1ccc(-c2c(-c3ccccc3)oc3ncnc(Oc4ccc(CCC(=O)O)cc4)c23)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)N1CCn2nc(Nc3cc(Br)cn(C)c3=O)cc2C1.CC(=O)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[K+].[Pd].[Pd]>>CC(=O)N1CCn2nc(Nc3cc(B4OC(C)(C)C(C)(C)O4)cn(C)c3=O)cc2C1",
        "output": "943"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CCO.Cc1c(C=O)[nH]c2c1C(=O)N(CCN1CCOCC1)CCC2.O=C1Cc2cc(S(=O)(=O)Cc3ccc(F)cc3)ccc2N1>>Cc1c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4ccc(F)cc4)cc32)[nH]c2c1C(=O)N(CCN1CCOCC1)CCC2",
        "output": "911"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CSc1ccccc1NC(C)=O.ClCCl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.[Na+]>>CC(=O)Nc1ccccc1S(C)=O",
        "output": "500"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COCC(=O)Cl.Nc1nc2ccccc2s1.c1ccncc1>>COCC(=O)Nc1nc2ccccc2s1",
        "output": "553"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCc1cnc(CCNC(=O)OCc2ccccc2)o1.CO.O=C[O-].[NH4+].[Pd]>>CCc1cnc(CCN)o1",
        "output": "574"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Nc1cccc(O)c1.OCCOc1cccc(Nc2nc(Cl)ncc2Cl)c1>>OCCOc1cccc(Nc2nc(Nc3cccc(O)c3)ncc2Cl)c1",
        "output": "808"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)P1(=NC(C)(C)C)N(C)CCCN1C.CN(C)C=O.COC(=O)Cc1c[nH]c2ncccc12.Clc1ccc(CBr)cc1Cl>>COC(=O)Cc1cn(Cc2ccc(Cl)c(Cl)c2)c2ncccc12",
        "output": "389"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CNCCN(C)C.Cn1c(-c2nnc3ccc(Cl)nn23)cnc1[N+](=O)[O-]>>CN(C)CCN(C)c1ccc2nnc(-c3cnc([N+](=O)[O-])n3C)n2n1",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCn1cc(-c2ccc(C3(c4nnc5n4CCSC(C)(CO[Si](C)(C)C(C)(C)C)C5)CC3)cc2)cn1.CO.Cl>>CCn1cc(-c2ccc(C3(c4nnc5n4CCSC(C)(CO)C5)CC3)cc2)cn1",
        "output": "708"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=C1NCCc2[nH]c(-c3cccc4ccc(Cl)nc34)cc21.Oc1cccc(Cl)c1.[H-].[Na+]>>O=C1NCCc2[nH]c(-c3cccc4ccc(Oc5cccc(Cl)c5)nc34)cc21",
        "output": "516"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[O-].Cc1cc(C)cc(N)c1.Cc1cccc(C)c1-c1ccc(Nc2nccnc2Cl)cc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Cc1cc(C)cc(Nc2nccnc2Nc2ccc(-c3c(C)cccc3C)cc2)c1",
        "output": "780"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CC(OCc2ccccc2)CC1CO.CCCCCC.CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.Cl.ClCCl>>CC(C)(C)OC(=O)N1CC(OCc2ccccc2)CC1COS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)CC(=O)O.COc1cc(-c2ccc3c(c2)Nc2ccc(N)cc2NC3=O)ccc1[N+](=O)[O-].F[P-](F)(F)(F)(F)F>>COc1cc(-c2ccc3c(c2)Nc2ccc(NC(=O)CN(C)C)cc2NC3=O)ccc1[N+](=O)[O-]",
        "output": "365"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@@H](OC(=O)NCCCCl)C1.CCO.CNC>>CN(C)CCCNC(=O)O[C@@H]1CCCN(C(=O)OC(C)(C)C)C1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.Cc1[nH]c(C)c(C#N)c1Br.[Cl-].[Na+]>>Cc1c(Br)c(C#N)c(C)n1C(=O)OC(C)(C)C",
        "output": "748"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.Cc1c(CC(=O)O)cc2ccc(F)cc2c1C(=O)c1ccc(S(C)(=O)=O)cc1.[H][H].[Pd]>>Cc1c(CC(=O)O)cc2ccc(F)cc2c1C(O)c1ccc(S(C)(=O)=O)cc1",
        "output": "157"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NC1CC1.O=C(O)c1n[nH]c2cc(Nc3nc(NC4CC4)c4occc4n3)ccc12.O=C([O-])[O-].O=C([O-])c1n[nH]c2ccccc12.[Na+].[Na+]>>O=C(NC1CC1)c1n[nH]c2cc(Nc3nc(NC4CC4)c4occc4n3)ccc12",
        "output": "816"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.CN(C)C=O.O=c1[nH]c2ccccc2n1C1CCNCC1>>CC(C)(C)OC(=O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1",
        "output": "694"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CS(C)=O.Cl.F[B-](F)(F)F.NCC(N)=O.O.O=C(O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4=O)cc3)n2)cc1>>NC(=O)CNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4=O)cc3)n2)cc1",
        "output": "718"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccccc1-c1nc2ccnc(C(F)(F)F)c2c(=O)n1[C@H](C)Cc1ccccc1.ClB(Cl)Cl.ClCCl.OCCNCCO>>C[C@H](Cc1ccccc1)n1c(-c2ccccc2O)nc2ccnc(C(F)(F)F)c2c1=O",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(N)CC1.CCN(CC)CC.COc1cc(Br)ccc1S(=O)(=O)Cl.COc1ccc(S(=O)(=O)Cl)c(Br)c1>>COc1cc(Br)ccc1S(=O)(=O)NC1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "43"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCC1CCCC(C(F)(F)F)C1.O=C(O)c1cn(C2CCOC2)c2cccc(Cl)c12>>O=C(NCC1CCCC(C(F)(F)F)C1)c1cn(C2CCOC2)c2cccc(Cl)c12",
        "output": "674"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(=O)C1CCNCC1.CN(C)C=O.COC(=O)CC1(CC(=O)OC)CC(c2cc(O)ccc2CCC(=O)O)=NO1.O.On1nnc2ccccc21>>CCOC(=O)C1CCN(C(=O)CCc2ccc(O)cc2C2=NOC(CC(=O)OC)(CC(=O)OC)C2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.Cn1c(=O)ccn(-c2ccc([N+](=O)[O-])cc2Cl)c1=O.[Cl-].[NH4+].[Zn]>>Cn1c(=O)ccn(-c2ccc(N)cc2Cl)c1=O",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCC2=NCCCN2CC1.CN(C)C=O.C[Si](C)(C)CCOCn1c(S(C)(=O)=O)nc2cc(Cl)c(I)nc21.O[C@@H]1CO[C@@H]2[C@H](O)CO[C@H]12>>C[Si](C)(C)CCOCn1c(O[C@@H]2CO[C@@H]3[C@H](O)CO[C@H]23)nc2cc(Cl)c(I)nc21",
        "output": "667"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NCC(N)c1ccccc1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1nc(C)c2cc(C(=O)Nc3cc(C(=O)O)ccc3Cl)c(=O)[nH]c2n1.F[P-](F)(F)(F)(F)F.O>>COc1nc(C)c2cc(C(=O)Nc3cc(C(=O)NC(CNC(=O)OC(C)(C)C)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1",
        "output": "753"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCBr.CN(C)C=O.Cn1c(=O)n(CCCO)c(=O)c2c(Cc3ccc(Cl)cc3)c(O)ccc21.O.O=C([O-])[O-].[K+].[K+]>>CCCOc1ccc2c(c1Cc1ccc(Cl)cc1)c(=O)n(CCCO)c(=O)n2C",
        "output": "75"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1Cc2ccc(-c3ccc(C(=O)O)nc3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1.Cl.F[C@H]1CCNC1>>CC1Cc2ccc(-c3ccc(C(=O)N4CC[C@H](F)C4)nc3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1",
        "output": "605"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCc1cccc(Br)c1.CCOC(C)=O.CN(C)C=O.COC(=O)CCc1ccc(O)cc1.[H-].[Na+]>>COC(=O)CCc1ccc(OCc2cccc(Br)c2)cc1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccccc1.NCC1CCNCC1.O=Cc1ccccc1.O=S(=O)([O-])O.[K+]>>CC(C)(C)OC(=O)N1CCC(CN)CC1",
        "output": "694"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1cc(N2CCC(O)CC2)c(F)cc1[N+](=O)[O-].CO.[Na+].[OH-]>>Nc1cc(N2CCC(O)CC2)c(F)cc1[N+](=O)[O-]",
        "output": "66"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)CC(C)c1ccc2c(c1)N(C(=O)OC(C)(C)C)CCN2.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc(CC(=O)O)ccc1NC(=O)Nc1ccccc1C.F[P-](F)(F)(F)(F)F>>CCOC(=O)CC(C)c1ccc2c(c1)N(C(=O)OC(C)(C)C)CCN2C(=O)Cc1ccc(NC(=O)Nc2ccccc2C)c(OC)c1",
        "output": "315"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.O=C(O)c1ccc2nc(-c3c(Cl)cccc3C(F)(F)F)[nH]c2c1.O=S(Cl)Cl>>O=C(Cl)c1ccc2nc(-c3c(Cl)cccc3C(F)(F)F)[nH]c2c1",
        "output": "3"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O=C(O)Cc1ccc2c(c1)C(=O)c1sccc1CO2.O=S(=O)(O)O>>COC(=O)Cc1ccc2c(c1)C(=O)c1sccc1CO2",
        "output": "17"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)[C@H](Cc1ccccc1)Nc1c(NCc2ccccc2)c(=O)c1=O.[Li+].[OH-]>>O=C(O)[C@H](Cc1ccccc1)Nc1c(NCc2ccccc2)c(=O)c1=O",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "N#Cc1cccc(Br)c1.Nc1ccc2ccccc2c1[N+](=O)[O-].O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])O.O=C([O-])[O-].[Cs+].[Cs+].[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>N#Cc1cccc(Nc2ccc3ccccc3c2[N+](=O)[O-])c1",
        "output": "405"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cccc(C=O)c4)cc23)CC1.CNC.CS(C)=O.[Na+]>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cccc(CN(C)C)c4)cc23)CC1",
        "output": "567"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Nc1cccc(SCCO)c1[N+](=O)[O-].[Pd]>>Nc1cccc(SCCO)c1N",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CCN(CC)CC.CN1CCNCC1.O=C(O)c1cc(S(=O)(=O)Cl)ccc1F>>CN1CCN(S(=O)(=O)c2ccc(F)c(C(=O)O)c2)CC1",
        "output": "99"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)C[C@H](N)C(=O)N1CC(O)C(SCc2ccccc2)C1.CCCCCC.CCN=C=NCCCN(C)C.CCOC(C)=O.CN1CCOCC1.Cl.ClCCl.O=C(O)C(F)(F)F.O=C(O)c1ccc2ccccc2n1.On1nnc2ccccc21>>CC(C)C[C@H](NC(=O)c1ccc2ccccc2n1)C(=O)N1CC(O)C(SCc2ccccc2)C1",
        "output": "738"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.C[C@H]1C[C@H](NC(=O)OC(C)(C)C)CN1Cc1ccccc1.[H][H].[Pd]>>C[C@H]1C[C@H](NC(=O)OC(C)(C)C)CN1",
        "output": "84"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)c1c(-c2ccc(F)cc2)nn2c1CCC2C.[Na+].[OH-]>>CC1CCc2c(C(=O)O)c(-c3ccc(F)cc3)nn21",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1sc(C)c2c(=O)n3cc(C(N)=O)ccc3nc12.ClC(Cl)Cl.O=P(Cl)(Cl)Cl.c1ccncc1>>Cc1sc(C)c2c(=O)n3cc(C#N)ccc3nc12",
        "output": "624"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.COC(=O)Cc1ccc(O)cc1F.COCc1noc(N2CCC([C@H]3C[C@H]3CCO)CC2)n1.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COCc1noc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)OC)c(F)c3)CC2)n1",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Nc1ccc(O)c(C(=O)O)c1.O>>CC(C)(C)OC(=O)Nc1ccc(O)c(C(=O)O)c1",
        "output": "735"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1c(Br)c(-c2cccc([N+](=O)[O-])c2)c(C)c(C#N)c1NC(=O)C(C)(C)C.ClCCl.O.O=C([O-])[O-].[Na+].[Na+]>>Cc1c(C#N)c(NC(=O)C(C)(C)C)c(O)c(Br)c1-c1cccc([N+](=O)[O-])c1",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OB(c2cc(Cl)c(O)c(Cl)c2)OC1(C)C.CCC(=O)c1cnc2ccc(Br)cc2c1N[C@@H]1CC[C@@H](N(C)C)CC1>>CCC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)cc2c1N[C@@H]1CC[C@@H](N(C)C)CC1",
        "output": "933"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)[C@@H](NS(C)(=O)=O)C(C)(C)C.Cl>>CC(C)(C)[C@H](NS(C)(=O)=O)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CO.Cl.NCC12CC3CC(C1)CC(C(=O)O)(C3)C2>>COC(=O)C12CC3CC(CC(CN)(C3)C1)C2",
        "output": "195"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.ClCCl.Cn1nc(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(-c4ccc(N)nc4)ccc3ncc21>>CC(=O)Nc1ccc(-c2ccc3ncc4c(c(-c5ccc(C(C)(C)C#N)cc5)nn4C)c3c2)cn1",
        "output": "394"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CCOC(=O)C1CCC(Oc2ccc(Cl)cc2[N+](=O)[O-])C1.ClCCl.[Zn]>>CCOC(=O)C1CCC(Oc2ccc(Cl)cc2N)C1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.NC(=O)c1cnc(Oc2ccc(C=O)cc2F)cn1.NCCc1ccc(F)cc1.[BH4-].[Na+]>>NC(=O)c1cnc(Oc2ccc(CNCCc3ccc(F)cc3)cc2F)cn1",
        "output": "468"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O=C(O)Cc1ccccc1F.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCc1ccccc1F",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClC(Cl)Cl.Fc1cc2[nH]c(S)nc2cc1N1CCNCC1.[Br-].[K+].[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCN(c2cc3nc(S)[nH]c3cc2F)CC1",
        "output": "694"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.COc1ccc2c(c1OC)C(=O)N1C[C@H](O)C[C@H]1C(=O)N2.O.c1c[nH]cn1>>COc1ccc2c(c1OC)C(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)C[C@H]1C(=O)N2",
        "output": "193"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCc1cccc(N)c1>>CC(C)(C)OC(=O)NCCc1cccc(N)c1",
        "output": "631"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)C=O.Nc1ccc(Oc2cncnc2)nc1.O=C(O)c1c[nH]c2ccccc12>>O=C(Nc1ccc(Oc2cncnc2)nc1)c1c[nH]c2ccccc12",
        "output": "863"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Cn1cc(Nc2nc3c(C4=CCN(C(=O)CCC(F)(F)F)CC4)cccn3n2)cn1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)Cn1cc(Nc2nc3c(C4=CCN(C(=O)CCC(F)(F)F)CC4)cccn3n2)cn1",
        "output": "278"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1sc2ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)cc2c1-c1ccccc1.O.[Na+].[OH-]>>CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3sc(C(=O)O)c(-c4ccccc4)c3c2)cc1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Cl.O.O=Cc1cc(C(F)(F)F)ccc1I.[BH4-].[Na+]>>OCc1cc(C(F)(F)F)ccc1I",
        "output": "356"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1ccc(Br)c(CBr)c1.[N-]=[N+]=[N-].[Na+]>>COc1ccc(Br)c(CN=[N+]=[N-])c1",
        "output": "643"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.Cc1cccc(C(=O)Cl)c1.Cl.Clc1ccc(Cl)cc1.[Al+3].[Cl-].[Cl-].[Cl-]>>Cc1cccc(C(=O)c2cc(Cl)ccc2Cl)c1",
        "output": "61"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCNCC1.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CC(F)(F)C(=O)N2C.F[P-](F)(F)(F)(F)F>>COc1cc(C(=O)N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CC(F)(F)C(=O)N2C",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Clc1ncnc(Cl)n1.N#Cc1cc(N)ccc1N1CCN(C2COC2)CC1.O>>N#Cc1cc(Nc2ncnc(Cl)n2)ccc1N1CCN(C2COC2)CC1",
        "output": "592"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OCC(=O)Nc1c(C)csc1C.CO.N>>Cc1csc(C)c1NC(=O)CO",
        "output": "687"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.Nc1ccc(F)c(-c2nn3c(c2-c2ccncc2)SCC3)c1F.O=S(=O)(Cl)c1cc(F)ccc1F.[K+].[OH-].c1ccncc1>>O=S(=O)(Nc1ccc(F)c(-c2nn3c(c2-c2ccncc2)SCC3)c1F)c1cc(F)ccc1F",
        "output": "68"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.N#Cc1c(F)cc(F)cc1Br.NN.O>>Nc1n[nH]c2cc(F)cc(Br)c12",
        "output": "945"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1ccc(C(F)(F)F)cc1.Nc1nc(Cl)cc(-c2cc(Cl)cc(Cl)c2Cl)n1>>Nc1nc(Nc2ccc(C(F)(F)F)cc2)cc(-c2cc(Cl)cc(Cl)c2Cl)n1",
        "output": "352"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.NCCN1CCC(CN2CCCCC2)C1.O=C1Nc2cccnc2N(C(=O)Cl)c2ccccc21>>O=C1Nc2cccnc2N(C(=O)NCCN2CCC(CN3CCCCC3)C2)c2ccccc21",
        "output": "454"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.CI.O=C([O-])[O-].Oc1ccc2cccnc2c1Br.[K+].[K+]>>COc1ccc2cccnc2c1Br",
        "output": "62"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](c2ccc(F)cc2)[C@H](CO)C1.CN(C)C=O.FC(F)(F)c1cc(CBr)cc(C(F)(F)F)c1.[H-].[Na+]>>CC(C)(C)OC(=O)N1CC[C@@H](c2ccc(F)cc2)[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1",
        "output": "464"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cl.N#Cc1c(I)c(C(=O)O)c(I)c(C(=O)O)c1I.O.[Na+].[OH-]>>NC(=O)c1c(I)c(C(=O)O)c(I)c(C(=O)O)c1I",
        "output": "419"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)N1CCC(N)CC1.COc1ccc(-c2nc3cc(OC)cc(OC)c3c(=O)[nH]2)c(F)c1.C[Si](C)(C)[N-][Si](C)(C)C.O.[Li+]>>COc1ccc(-c2nc3cc(OC)cc(OC)c3c(=O)[nH]2)c(NC2CCN(C(C)C)CC2)c1",
        "output": "572"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1ccc2c(c1)nc(Nc1c(F)cccc1F)n2C.O.[Na+].[OH-]>>Cn1c(Nc2c(F)cccc2F)nc2cc(C(=O)O)ccc21",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1ccc(-c2cc(C(=O)O)cc(C(O)c3ccccn3)c2)cc1.Cc1ccc([C@@H](C)N)cn1.Cl.Cl>>Cc1ccc(-c2cc(C(=O)N[C@H](C)c3ccc(C)nc3)cc(C(O)c3ccccn3)c2)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCc1ccc2c(c1)oc1cc([Sn](C)(C)C)ccc12.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.[Cl-].[F-].[NH4+]>>C[Sn](C)(C)c1ccc2c(c1)oc1cc(CO)ccc12",
        "output": "708"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C(O)c1ccc(O)c(Cl)c1.O=C([O-])O.O=S(=O)(O)O.[Na+]>>COC(=O)c1ccc(O)c(Cl)c1",
        "output": "33"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1cccc([N+](=O)[O-])c1Br.ClCCl.Cl[Sn]Cl.O.[Na+].[OH-]>>COC(=O)c1cccc(N)c1Br",
        "output": "481"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCC(=O)Cl.CCN(CC)CC.ClCCl.Cn1c(-c2cncc(CN)c2)c(C#N)c2ccc(Cl)cc21>>CCCC(=O)NCc1cncc(-c2c(C#N)c3ccc(Cl)cc3n2C)c1",
        "output": "45"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.ClCCBr.O=C([O-])[O-].Oc1ccc(Cl)cc1.[K+].[K+]>>ClCCOc1ccc(Cl)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.COC(=O)c1ccccc1-c1cc(-c2ccc(OC)cc2)on1.Cl.O>>COc1ccc(-c2cc(-c3ccccc3C(=O)O)no2)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CCCCCCN.O=C(O)/C=C/c1ccc(O)c(O)c1>>CCCCCCNC(=O)/C=C/c1ccc(O)c(O)c1",
        "output": "767"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O.O=C(O)c1ccc(CCCBr)cc1.O=S(=O)(O)O.c1ccccc1>>CCOC(=O)c1ccc(CCCBr)cc1",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)C(C)(C)Cc1ncc(-c2ccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)cc2)o1.O=C(O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1>>CC(C)(Cc1ncc(-c2ccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)cc2)o1)C(=O)O",
        "output": "361"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCOCCOCCOCCOCCO1.CC(C)Br.O=[N+]([O-])c1cc(Br)ccc1O.[K+].[OH-].c1ccccc1>>CC(C)Oc1ccc(Br)cc1[N+](=O)[O-]",
        "output": "153"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(N2CCOCC2)c2sc(NC(=O)c3ccnc(Br)c3)nc12.O=C([O-])[O-].OC1CCNCC1.[Cs+].[Cs+]>>COc1ccc(N2CCOCC2)c2sc(NC(=O)c3ccnc(N4CCC(O)CC4)c3)nc12",
        "output": "647"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=NOCCO)c1ccc2ccccc2c1.CCOC(=O)N=NC(=O)OCC.O=C1SC(Cc2ccc(O)cc2)C(=O)N1C(c1ccccc1)(c1ccccc1)c1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(=NOCCOc1ccc(CC2SC(=O)N(C(c3ccccc3)(c3ccccc3)c3ccccc3)C2=O)cc1)c1ccc2ccccc2c1",
        "output": "550"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CO.O.O=C1CCc2cc(Br)ccc21.[Cl-].[NH3+]O.[Na+]>>ON=C1CCc2cc(Br)ccc21",
        "output": "212"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.Cl.Cl.NCc1ccc(F)cn1.O=[N+]([O-])c1cnc(-c2cnc3ccc(F)cn23)nc1Cl>>O=[N+]([O-])c1cnc(-c2cnc3ccc(F)cn23)nc1NCc1ccc(F)cn1",
        "output": "166"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NC(=O)c1nc2n(c1C(=O)O)C1CC(C1)c1ccc(Br)cc1-2.NC1CC1>>NC(=O)c1nc2n(c1C(=O)NC1CC1)C1CC(C1)c1ccc(Br)cc1-2",
        "output": "697"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCc2c(sc3ccc(Br)cc23)C1.CS(C)=O.O=C([O-])[O-].O=c1cc(OCc2ccccc2)cc[nH]1.Oc1cccc2cccnc12.[Cu]I.[K+].[K+]>>CC(C)(C)OC(=O)N1CCc2c(sc3ccc(-n4ccc(OCc5ccccc5)cc4=O)cc23)C1",
        "output": "349"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC1CCNCC1.O=[N+]([O-])c1cnc(Cl)nc1Cl>>CC1CCN(c2nc(Cl)ncc2[N+](=O)[O-])CC1",
        "output": "296"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Nc1nccc(Oc2cc(F)ccc2F)c1I.O=C([O-])O.O=S(=O)(O)O.O=[N+]([O-])O.[Na+]>>Nc1nccc(Oc2cc(F)c([N+](=O)[O-])cc2F)c1I",
        "output": "21"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)N1CCCC(C(=O)O)C1.ClCCl.Nc1ccccc1F>>CC(C)(C)OC(=O)N1CCCC(C(=O)Nc2ccccc2F)C1",
        "output": "365"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COC(=O)C[C@@H]1Cc2ccc(OC)cc2CN(Cc2ccc(C(F)(F)F)cc2)C1=O.ClCCl>>COC(=O)C[C@@H]1Cc2ccc(O)cc2CN(Cc2ccc(C(F)(F)F)cc2)C1=O",
        "output": "732"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COc1ccc([Si](C)(C)C)cc1[N+](=O)[O-].[H][H].[Pd]>>COc1ccc([Si](C)(C)C)cc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COc1cccc2c1NC(=O)N(C1CCN(Cc3ccccc3)CC1)C2.[Pd]>>COc1cccc2c1NC(=O)N(C1CCNCC1)C2",
        "output": "84"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)n1c([C@H](C)NC(=O)OC(C)(C)C)nc2ccc(F)c(-c3ccccn3)c21.ClCCl.O=C(O)C(F)(F)F>>CC(C)n1c([C@H](C)N)nc2ccc(F)c(-c3ccccn3)c21",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.CO.COc1cc2cn[nH]c(=O)c2cc1OC.ClC(Cl)Cl.ClCCCBr>>COc1cc2cnn(CCCCl)c(=O)c2cc1OC",
        "output": "577"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2c(-c3cccc(F)c3)cnc3[nH]ccc23)CC1.Cl.Cl.ClCCl.Nc1c(F)c(N)c(F)c(F)c1F.O=C(O)C(F)(F)F>>Fc1cccc(-c2cnc3[nH]ccc3c2N2CCNCC2)c1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CN(C)C=O.Cc1cccc(C(=O)O)c1OCc1ccccc1.O=C(Cl)C(=O)Cl>>Cc1cccc(C(=O)Cl)c1OCc1ccccc1",
        "output": "448"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1c[nH]nc1C(F)(F)F.OB(O)c1ccc2[nH]ccc2c1>>CCOC(=O)c1cn(-c2ccc3[nH]ccc3c2)nc1C(F)(F)F",
        "output": "925"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(N)CO.O>>CC(C)(CO)NC(=O)OC(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(NC(=O)c1ccc(-c2cnc3ncc(C4(c5ccc6ncccc6c5)CC4)n3c2)cc1F)C(=O)O.CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CNC.F[P-](F)(F)(F)(F)F>>CC(NC(=O)c1ccc(-c2cnc3ncc(C4(c5ccc6ncccc6c5)CC4)n3c2)cc1F)C(=O)N(C)C",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.NS(=O)(=O)c1nc2ccc(O)cc2s1.c1ccncc1>>Cc1ccc(S(=O)(=O)Oc2ccc3nc(S(N)(=O)=O)sc3c2)cc1",
        "output": "380"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=[N+]([O-])c1ccc(F)cc1OC(CF)CF.[Ni]>>Nc1ccc(F)cc1OC(CF)CF",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.ClCCl.ClCCl.O=C([O-])O.O=c1[nH]c(=O)n(C2CSC(COCc3ccccc3)CO2)cc1F.[Na+]>>O=c1[nH]c(=O)n(C2CSC(CO)CO2)cc1F",
        "output": "178"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cl.O=C(O)CCc1ccc(O)cc1>>CCOC(=O)CCc1ccc(O)cc1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CNC.COc1ccc2c(c1)c(-c1cc3c4c(cnc3n1S(=O)(=O)c1ccc(C)cc1)cnn4C)cn2CC1CO1>>COc1ccc2c(c1)c(-c1cc3c4c(cnc3n1S(=O)(=O)c1ccc(C)cc1)cnn4C)cn2CC(O)CN(C)C",
        "output": "76"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.C1COCCO1.CC(C)(C)[O-].CCCc1cccc(CCC)c1-n1cc[n+](-c2c(CCC)cccc2CCC)c1.O=c1cc(Oc2ccccc2)c2cc(Br)ccc2[nH]1.[Cl-].[K+]>>O=c1cc(Oc2ccccc2)c2cc(N3CCOCC3)ccc2[nH]1",
        "output": "294"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)CCCNc1ccc(-c2ccccc2)cc1.O=C(Cl)c1ccc(Cl)cc1.c1ccccc1>>CCOC(=O)CCCN(C(=O)c1ccc(Cl)cc1)c1ccc(-c2ccccc2)cc1",
        "output": "614"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1CCCCN1.CCOCC.CS(C)=O.N#Cc1ccc(F)c(C(F)(F)F)c1>>CC1CCCCN1c1ccc(C#N)cc1C(F)(F)F",
        "output": "26"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "FC(F)(F)c1cnc(Cl)nc1.NC1CCCc2c1[nH]c1ccc(Br)cc21>>FC(F)(F)c1cnc(NC2CCCc3c2[nH]c2ccc(Br)cc32)nc1",
        "output": "544"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCN1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COC(=O)c1ccc2c(C3CCCCC3)c(Br)n(CC(=O)O)c2c1.F[P-](F)(F)(F)(F)F>>COC(=O)c1ccc2c(C3CCCCC3)c(Br)n(CC(=O)N3CCOCC3)c2c1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(CN)c1ccc(C(=O)Nc2cn3cc(Cl)ccc3n2)cc1.CCN=C=NCCCN(C)C.O=C(O)C(O)CO.On1nnc2ccccc21>>CC(C)(CNC(=O)C(O)CO)c1ccc(C(=O)Nc2cn3cc(Cl)ccc3n2)cc1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCNCCCO.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COC(=O)c1ccc2c(c1)N=C(N)CC(C(=O)O)=C2.Cl.F[P-](F)(F)(F)(F)F.O>>CCCN(CCCO)C(=O)C1=Cc2ccc(C(=O)OC)cc2N=C(N)C1",
        "output": "517"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.NCC1Cc2cccc(-c3ccccc3Cl)c2O1.O=C(Cl)OCc1ccccc1>>O=C(NCC1Cc2cccc(-c3ccccc3Cl)c2O1)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)(C)C(=O)CCl.ClCCl.N#Cc1ccc(NCCCN2CC3CNCC(C2)O3)cc1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)C(=O)CN1CC2CN(CCCNc3ccc(C#N)cc3)CC(C1)O2",
        "output": "414"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)O.CCc1cc(C(=O)O)c2cc(C(C)C)cccc1-2>>CCc1cc(C(=O)OC(C)C)c2cc(C(C)C)cccc1-2",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CN(C)CCn1c(=O)c2ccc([N+](=O)[O-])cc2c2cnc3cc4c(cc3c21)OCO4.NN.O.[Ni]>>CN(C)CCn1c(=O)c2ccc(N)cc2c2cnc3cc4c(cc3c21)OCO4",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.Cl.O=C(O)c1cc(COC(=O)c2c(-c3ccccc3)c3cc(Br)ccc3c(=O)n2Cc2ccccc2)ccn1.O=S(=O)(O)O>>COC(=O)c1cc(COC(=O)c2c(-c3ccccc3)c3cc(Br)ccc3c(=O)n2Cc2ccccc2)ccn1",
        "output": "331"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.O=C1C(=O)N2CCOc3cccc1c32.O=[N+]([O-])O>>O=C1C(=O)N2CCOc3cc([N+](=O)[O-])cc1c32",
        "output": "21"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)c1cncc(Br)c1.COC(OC)N(C)C>>CN(C)C=CC(=O)c1cncc(Br)c1",
        "output": "576"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrBr.CC(=O)O.CNc1c([N+](=O)[O-])ccc(-c2ccccc2Cl)c1C#N>>CNc1c([N+](=O)[O-])cc(Br)c(-c2ccccc2Cl)c1C#N",
        "output": "98"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCc1cccc(N)c1.O=C1CCC(=O)N1Cl>>CCc1cc(N)ccc1Cl",
        "output": "121"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cc1cc([N+](=O)[O-])c(C)c(Cl)c1O.[Pt]>>Cc1cc(N)c(C)c(Cl)c1O",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCC(O)CCC.CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.[Na+]>>CCCC(CCC)OC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(C)c1C",
        "output": "960"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(C=O)cc1.c1cc2[nH]ncc2cc1NC1CC2CCC1N2>>Cc1ccc(CN2C3CCC2C(Nc2ccc4[nH]ncc4c2)C3)cc1",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.N#Cc1ccncc1.NO>>N=C(NO)c1ccncc1",
        "output": "854"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)n1nc(CCCO)c2c(Nc3c(-c4ncccn4)oc4cnccc34)cccc21.ClCCl.O=C(O)C(F)(F)F>>OCCCc1n[nH]c2cccc(Nc3c(-c4ncccn4)oc4cnccc34)c12",
        "output": "896"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCOC(C)=O.CNC.COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(N3CCCc4cc(S(=O)(=O)Cl)ccc43)nc2c1.Cl.ClCCl>>COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(N3CCCc4cc(S(=O)(=O)N(C)C)ccc43)nc2c1",
        "output": "99"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COc1ccc2[nH]cc(-c3cc4c(OC)ncnc4n3S(=O)(=O)c3ccc(C)cc3)c2c1.[K+].[OH-]>>COc1ccc2[nH]cc(-c3cc4c(OC)ncnc4[nH]3)c2c1",
        "output": "949"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1[nH]c(C2Cc3ccccc3CN2C(=O)OC(C)(C)C)nc1-c1ccccc1.O=C(O)C(F)(F)F>>Cc1[nH]c(C2Cc3ccccc3CN2)nc1-c1ccccc1",
        "output": "887"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCc1nc(SC)ncc1CO.CI>>CCc1nc(SC)ncc1COC",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.NC(=O)N1CCCc2cc(-c3cncc(OCc4ccccc4)c3)cnc21.[Pd]>>NC(=O)N1CCCc2cc(-c3cncc(O)c3)cnc21",
        "output": "264"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CO.Cl.ClCCl.Cn1cc(Nc2ncc(Cl)c(NC3CCCC(NC(=O)OC(C)(C)C)C3)n2)cn1>>Cn1cc(Nc2ncc(Cl)c(NC3CCCC(N)C3)n2)cn1",
        "output": "538"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)c1c(CN(C(=O)OCc2ccccc2)S(=O)(=O)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)ccc2ccccc12.ClCCl.O=C(O)C(F)(F)F>>O=C(O)c1c(CN(C(=O)OCc2ccccc2)S(=O)(=O)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)ccc2ccccc12",
        "output": "752"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#Cc1cc2c(cc1C)OC(C)(C)CC2(C)C.CCN(CC)CC.CCOC(=O)c1ccc(Cl)nc1.Cl[Pd]Cl.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1ccc(C#Cc2cc3c(cc2C)OC(C)(C)CC3(C)C)nc1",
        "output": "818"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1ccnc(NC(=O)NC(C)C)c1.CO.[Na+].[OH-]>>CC(C)NC(=O)Nc1cc(C(=O)O)ccn1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C[C@H](N)Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1.O=C(O)c1ccc(-n2cccn2)nn1>>C[C@@H](Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1)NC(=O)c1ccc(-n2cccn2)nn1",
        "output": "816"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)Cc2cccc(C(=O)O)c2O1.Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CN)c1>>Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2cccc3c2OC(C)(C)C3)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)[C@@H](C)[C@H](c1ccc2c(c1)OC(c1ccc(-c3ccnc(OC)c3)cc1F)CC2)C1CC1.[Li+].[OH-]>>COc1cc(-c2ccc(C3CCc4ccc([C@H](C5CC5)[C@H](C)C(=O)O)cc4O3)c(F)c2)ccn1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#Cc1cc(Nc2cc(Oc3ccc(N)c4ccccc34)ccn2)cc(C(=O)NCCOCCOCCOC)c1.CC(=O)OC(C)C.CCN(CC)CC.COc1c(NC(=O)Oc2ccccc2)cc(C(C)(C)C)cc1C(N)=O>>C#Cc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(C(N)=O)c4OC)c4ccccc34)ccn2)cc(C(=O)NCCOCCOCCOC)c1",
        "output": "965"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCNCC1.CCO.N#Cc1cc([N+](=O)[O-])ccc1Cl>>N#Cc1cc([N+](=O)[O-])ccc1N1CCCCC1",
        "output": "105"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCc1ccccc1.CC(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3n[nH]c4cc(Cl)ccc34)nc12.CN(C)C=O.O.[H-].[Na+]>>CC(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(Cc4ccccc4)c4cc(Cl)ccc34)nc12",
        "output": "635"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)[C@H](Cc1ccccc1)Nc1cc(-c2ccc(COc3ccccc3)cc2)ncn1.[Na+].[OH-]>>O=C(O)[C@H](Cc1ccccc1)Nc1cc(-c2ccc(COc3ccccc3)cc2)ncn1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(Nc2c(C(=O)C3CC3)cnc3ccc(Br)cc23)cc1.CC1(C)OB(c2cc(F)c(O)c(Cl)c2)OC1(C)C>>CC(C)(C)OC(=O)NCc1ccc(Nc2c(C(=O)C3CC3)cnc3ccc(-c4cc(F)c(O)c(Cl)c4)cc23)cc1",
        "output": "933"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=Cc1ccc(S(=O)(=O)Cl)cc1.CC(C)c1ccc(N)nc1.c1ccncc1>>C=Cc1ccc(S(=O)(=O)Nc2ccc(C(C)C)cn2)cc1",
        "output": "462"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.ClCCl.O=Cc1ccc(OC2CCCC2)cc1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>O=Cc1ccc(OC2CCCC2)cc1OS(=O)(=O)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(C)(C)c1cc(C=O)ccc1O.CCOCC.Cl.NO>>CC(C)(C)c1cc(C#N)ccc1O",
        "output": "453"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)C(C#N)(CCCI)c1ccc(C#N)s1.CCN(CC)CC.N#Cc1ccc(CCCN2CCNCC2)s1>>CC(C)C(C#N)(CCCN1CCN(CCCc2ccc(C#N)s2)CC1)c1ccc(C#N)s1",
        "output": "184"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "NCC(NC(=O)OCc1ccccc1)C(=O)N1CCCCC1.O=C(Cl)C1CCN(c2ccncc2)CC1>>O=C(NC(CNC(=O)C1CCN(c2ccncc2)CC1)C(=O)N1CCCCC1)OCc1ccccc1",
        "output": "45"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCOC(C)=O.CO.COc1ccc2ncc(=O)n(CCN3CCC(N)CC3)c2c1.ClC(Cl)Cl.O=C([O-])O.O=Cc1ccc2c(c1)NC(=O)CO2.[BH3-]C#N.[Na+].[Na+]>>COc1ccc2ncc(=O)n(CCN3CCC(NCc4ccc5c(c4)NC(=O)CO5)CC3)c2c1",
        "output": "468"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cn1cc(C=CC(=O)O)cn1.O=C([O-])[O-].O=S(=O)(O)O.[Na+].[Na+]>>COC(=O)C=Cc1cnn(C)c1",
        "output": "174"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Nc1cccc(CO)c1.O=[N+]([O-])c1cc(C(F)(F)F)c(F)cc1F>>O=[N+]([O-])c1cc(C(F)(F)F)c(F)cc1Nc1cccc(CO)c1",
        "output": "609"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=CCc1cc(C(=O)OCC)ccc1OC.CCO.Cl.[Na+].[OH-]>>C=CCc1cc(C(=O)O)ccc1OC",
        "output": "386"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1ccc(CCO)cn1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCCc2ccc(C(C)(C)C)nc2)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#CCC(Cc1cccnc1)(C(=O)O)S(=O)(=O)c1ccc(F)cc1.Cl.NO>>CC#CCC(Cc1cccnc1)(C(=O)NO)S(=O)(=O)c1ccc(F)cc1",
        "output": "480"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.Cc1cccc(Cl)n1.O=C([O-])O.OO.[Na+]>>Cc1cccc(Cl)[n+]1[O-]",
        "output": "396"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COc1ccc(OC)c(CC(=O)O)c1.O=S(=O)(O)O>>COC(=O)Cc1cc(OC)ccc1OC",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)CCOCCOc1nc(NCc2cccc(C(F)(F)F)c2)c2cc(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)ccc2n1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)CCOCCOc1nc(NCc2cccc(C(F)(F)F)c2)c2cc(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)ccc2n1",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Cl.CO.O=C(O)Cc1ccsc1>>COC(=O)Cc1ccsc1",
        "output": "195"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)[O-].CC1(C)OB(O)c2cc(F)c(C=O)cc21.Cl.NO.O.[Na+]>>CC1(C)OB(O)c2cc(F)c(C=NO)cc21",
        "output": "30"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.[H][H].[N-]=[N+]=NCCc1ccc(C(N)=O)cc1.[Pd]>>NCCc1ccc(C(N)=O)cc1",
        "output": "89"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)[C@H]1CCCC[C@H]1O.COc1ccc2c(C(=O)c3ccc(F)cc3)c(-c3ccc(OCCN4CCCC4)cc3)sc2c1>>COc1ccc2c(C(=O)c3ccc(O[C@@H]4CCCC[C@@H]4N(C)C)cc3)c(-c3ccc(OCCN4CCCC4)cc3)sc2c1",
        "output": "485"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CS(=O)(=O)OCCc1cc2cc(-c3cccc(C#N)c3)ccc2o1.C[C@@H]1CCCN1.ClCCl.O=C([O-])[O-].[Cs+].[Cs+]>>C[C@@H]1CCCN1CCc1cc2cc(-c3cccc(C#N)c3)ccc2o1",
        "output": "496"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCNCC1.COc1cc(F)ccc1[N+](=O)[O-].CS(C)=O.O.O=C([O-])[O-].[K+].[K+]>>COc1cc(N2CCN(C)CC2)ccc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.NCc1nccs1.O=C(O)c1ccc(N2CC3=C(CN(C(=O)c4ccccc4C(F)(F)F)C3)C2)nc1>>O=C(NCc1nccs1)c1ccc(N2CC3=C(CN(C(=O)c4ccccc4C(F)(F)F)C3)C2)nc1",
        "output": "674"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)c1nn(-c2c(Cl)cccc2Cl)nc1COc1ccccc1.O.O.[K+].[OH-]>>O=C(O)c1nn(-c2c(Cl)cccc2Cl)nc1COc1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1=COCCC1.C1CCOC1.CC(=O)OCCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2[C@@H](F)C[C@]3(C)C(=O)CC[C@H]3[C@H]12.CCN(CC)CC.CCOC(C)=O.Cc1ccc(S(=O)(=O)O)cc1>>CC(=O)OCCCCC[C@@H]1Cc2cc(OC3CCCCO3)ccc2[C@H]2[C@@H](F)C[C@]3(C)C(=O)CC[C@H]3[C@H]12",
        "output": "319"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.C[Si](C)(C)CCOC(=O)NC1CC2(CCNCC2)c2c(Br)cccc21.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)C=Cc1ccccc1C(F)(F)F>>C[Si](C)(C)CCOC(=O)NC1CC2(CCN(C(=O)/C=C/c3ccccc3C(F)(F)F)CC2)c2c(Br)cccc21",
        "output": "517"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCc2cc(NC(=O)C3=C(c4ccc(C(F)(F)F)cc4)CCCC3)ccc2C1.ClCCl.O=C(O)C(F)(F)F>>O=C(Nc1ccc2c(c1)CCNC2)C1=C(c2ccc(C(F)(F)F)cc2)CCCC1",
        "output": "887"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.Cl[Pd]Cl.O.O=C(O)c1ccc2cncc(Br)c2n1.O=C([O-])[O-].OB(O)c1ccc(Cl)cc1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=C(O)c1ccc2cncc(-c3ccc(Cl)cc3)c2n1",
        "output": "871"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc(CO)c1C#N.ClCCl.[Mn+4].[O-2].[O-2]>>CC#CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc(C=O)c1C#N",
        "output": "287"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCCCCCCc1ccc(-c2ccsc2)s1.CN(C)C=O.O=C1CCC(=O)N1Br>>CCCCCCCCCCCCc1ccc(-c2ccsc2Br)s1",
        "output": "807"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCS.CN(C)C=O.COc1c(C(C)=O)cc2c(c1Br)C(C)(C)CC=C2C(C)(C)C.[H-].[Na+]>>CC(=O)c1cc2c(c(Br)c1O)C(C)(C)CC=C2C(C)(C)C",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.COC(=O)Cc1cc2ccc(F)cc2c(-c2ccc(NS(=O)(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2)c1C.[Na+].[OH-]>>Cc1c(CC(=O)O)cc2ccc(F)cc2c1-c1ccc(NS(=O)(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)c1ccc(N)nc1.Cc1noc(C)c1COc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>Cc1noc(C)c1COc1ccc(S(=O)(=O)Nc2ccc(C(C)C)cn2)cc1",
        "output": "462"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCN(CC)CC.CCO.COCCCn1cc(N)cn1.N#Cc1cc(-c2ccnc(Cl)n2)ccc1OC1CCOCC1>>COCCCn1cc(Nc2nccc(-c3ccc(OC4CCOCC4)c(C#N)c3)n2)cn1",
        "output": "992"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.CCCN(C(=O)[C@@H](NC(=O)[C@H]1CCCCN1C)C(C)C)[C@H](C[C@@H](O)c1nc(C(=O)O)cs1)C(C)C.O.c1ccncc1>>CCCN(C(=O)[C@@H](NC(=O)[C@H]1CCCCN1C)C(C)C)[C@H](C[C@@H](OC(C)=O)c1nc(C(=O)O)cs1)C(C)C",
        "output": "254"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1nc2cc(OC3CCN(C(=O)OC(C)(C)C)CC3)c(O[Si](C)(C)C(C)(C)C)cc2n1Cc1ccc(C#N)c2ccccc12.[F-]>>Cc1nc2cc(OC3CCN(C(=O)OC(C)(C)C)CC3)c(O)cc2n1Cc1ccc(C#N)c2ccccc12",
        "output": "754"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.N#Cc1cccc(C=O)c1.O=C(Nc1ccc(N2CCNCC2)cc1)C1=C(c2ccc(C(F)(F)F)cc2)CCCC1.[Na+]>>N#Cc1cccc(CN2CCN(c3ccc(NC(=O)C4=C(c5ccc(C(F)(F)F)cc5)CCCC4)cc3)CC2)c1",
        "output": "567"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)CCNCc1ccccc1.CCN(CC)CC.Cl.ClCCl.O.O=C(O)C1Cc2c(Cl)cccc21.O=P1([O-])OP(=O)([O-])OP(=O)([O-])OP(=O)([O-])O1.[Na+].[Na+].[Na+].[Na+]>>CC(=O)CCN(Cc1ccccc1)C(=O)C1Cc2c(Cl)cccc21",
        "output": "633"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)[C@H]1CCCN1C(=O)c1ccccc1-c1ccc(OCC2CCN(CC(C)(C)F)CC2)cc1.Cl.O.O.[Li]O>>CC(C)(F)CN1CCC(COc2ccc(-c3ccccc3C(=O)N3CCC[C@@H]3C(=O)O)cc2)CC1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cl.O=c1[nH]c(C2CCNC2)cc2ccccc12.OCCBr>>O=c1[nH]c(C2CCN(CCO)C2)cc2ccccc12",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCN(C2CCNCC2)CC1.C1CCOC1.O=[N+]([O-])c1ccc(F)c(F)c1>>O=[N+]([O-])c1ccc(N2CCC(N3CCCCC3)CC2)c(F)c1",
        "output": "26"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCOC(C)=O.O=C(CBr)Nc1ccc2ncnn2n1.O=C([O-])[O-].[K+].[K+].c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>O=C(CN1CCN(C(c2ccccc2)c2ccccc2)CC1)Nc1ccc2ncnn2n1",
        "output": "443"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)CNc1cccc(C(=O)O)c1.CCNCC.O.O=C(c1ncc[nH]1)c1ncc[nH]1>>CCN(CC)C(=O)c1cccc(NCC(=O)OC(C)(C)C)c1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(N)c1ncco1.O=C(O)c1ccc(N2CCCC2=O)c(OCC2CC2)n1>>CC(C)(NC(=O)c1ccc(N2CCCC2=O)c(OCC2CC2)n1)c1ncco1",
        "output": "137"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CN(CCO)C(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCCN(C)C(=O)OC(C)(C)C)cc1",
        "output": "197"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)C(C)N1CCCC1.NN.O>>CC(C(=O)NN)N1CCCC1",
        "output": "164"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1c(-c2ccc(N(C)C)nc2)nc2cc(F)cc(F)c2c1Cl.Cc1ccccc1.Nc1cncc(N2CCOCC2)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1c(-c2ccc(N(C)C)nc2)nc2cc(F)cc(F)c2c1Nc1cncc(N2CCOCC2)c1",
        "output": "859"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.Cc1cnc(Cl)nc1NC1CCC2(CC1)CCN(C(=O)OC(C)(C)C)CC2.Cl.Cn1cc(N)cn1>>Cc1cnc(Nc2cnn(C)c2)nc1NC1CCC2(CC1)CCN(C(=O)OC(C)(C)C)CC2",
        "output": "992"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cn(C(C)(C)C)c2ccc(I)cc2c1=O.O.[Na+].[OH-]>>CC(C)(C)n1cc(C(=O)O)c(=O)c2cc(I)ccc21",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)(C)OC(=O)Nc1cncc(Br)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.[K+]>>CC(C)(C)OC(=O)Nc1cncc(B2OC(C)(C)C(C)(C)O2)c1",
        "output": "943"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)Cl.Nc1ccc(N)c([N+](=O)[O-])c1.c1ccncc1>>CS(=O)(=O)Nc1ccc(N)c([N+](=O)[O-])c1",
        "output": "194"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCO.COCC(=O)c1ccc(OC(F)(F)F)c(F)c1.Cl.NO>>COCC(=NO)c1ccc(OC(F)(F)F)c(F)c1",
        "output": "212"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCNC.CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)O)CC1>>CCCN(C)C(=O)CC1CCN(C(=O)N2C(c3cnc(C(C)(C)C)cc3OCC)=N[C@@](C)(c3ccc(Cl)cc3)[C@@]2(C)c2ccc(Cl)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.CC(C)=O.O.O=C(Cl)OCc1ccccc1.O=C([O-])[O-].OCC1CCC2CNCCN2C1.[Na+].[Na+]>>O=C(OCc1ccccc1)N1CCN2CC(CO)CCC2C1",
        "output": "427"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.O=C(Nc1ccc(F)cc1)N1CCN(c2cc(NCCNC(=O)C(F)(F)F)nc3cc(Cl)ccc23)CC1.[K+].[OH-]>>NCCNc1cc(N2CCN(C(=O)Nc3ccc(F)cc3)CC2)c2ccc(Cl)cc2n1",
        "output": "805"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)[C@H](Cc1ccccc1)NC(=O)CC1CCN(c2cc(C)nc3c2c(C)cn3-c2c(C)cc(Br)cc2C)CC1.O=S(=O)([O-])O.[K+].[Na+].[OH-]>>Cc1cc(N2CCC(CC(=O)N[C@@H](Cc3ccccc3)C(=O)O)CC2)c2c(C)cn(-c3c(C)cc(Br)cc3C)c2n1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[O-].C[C@@H]1CNCCN1.Cc1ccccc1.Fc1ccc(-c2ccc(Br)cc2)cc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>C[C@@H]1CN(c2ccc(-c3ccc(F)cc3)cc2)CCN1",
        "output": "294"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCO.CCOC(C)=O.COc1ccc(B(O)O)cc1.Cl.Cl[Pd]Cl.O=C(O)c1cc2c(Br)cccc2[nH]1.O=C([O-])[O-].[Na+].[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(-c2cccc3[nH]c(C(=O)O)cc23)cc1",
        "output": "909"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=C(O)c1ccc(Br)c[n+]1[O-].O=S(Cl)Cl>>COC(=O)c1ccc(Br)c[n+]1[O-]",
        "output": "331"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)NCCCCCCCC=O)c4)cc23)c1.COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)Nc5ccc(C#CCCCCO)cc5)c4)cc23)c1>>COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)Nc5ccc(C#CCCCC=O)cc5)c4)cc23)c1",
        "output": "142"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCCOCCOc1ccc(C2CCC(N)CC2)cc1.Cc1nccc(Cl)c1Cl>>CCOCCOCCOc1ccc(C2CCC(Nc3ccnc(C)c3Cl)CC2)cc1",
        "output": "78"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCCC1=O.CNCCNC.Cc1cc[nH]c(=O)c1N1CCc2nc(N)ncc2C1.Cc1ccc(I)cc1.I[Cu]I.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>Cc1ccc(-n2ccc(C)c(N3CCc4nc(N)ncc4C3)c2=O)cc1",
        "output": "267"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.COCc1cc(Nc2nc3ccc(Br)cc3s2)nc(S(C)(=O)=O)n1.N[C@H]1CC[C@H](O)CC1.O>>COCc1cc(Nc2nc3ccc(Br)cc3s2)nc(N[C@@H]2CC[C@@H](O)CC2)n1",
        "output": "629"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(N)C(=O)O>>CC(C)(C)OC(=O)NC(C)(C)C(=O)O",
        "output": "626"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.Cc1cc(Cl)ccc1C1c2c(ccn2C(C)C)C(=O)N1c1cccc(Cl)c1F.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>Cc1cc(Cl)ccc1C1c2c(cc(Br)n2C(C)C)C(=O)N1c1cccc(Cl)c1F",
        "output": "779"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)Nc1cc(COC(C)=O)ccn1.O.[Na+].[OH-]>>CC(=O)Nc1cc(CO)ccn1",
        "output": "348"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1[C@@H](Cc2ccc(O)cc2)COC1(C)C.CN(C)CC(=O)O.COc1ccc(I)cc1.ClCCl.O=C([O-])[O-].[Cs+].[Cs+]>>COc1ccc(Oc2ccc(C[C@H]3COC(C)(C)N3C(=O)OC(C)(C)C)cc2)cc1",
        "output": "382"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1cc(C=CC(=O)OC(C)(C)C)cc(C)c1N(C)S(=O)(=O)c1ccc(OC)cc1.O=C(O)C(F)(F)F>>COC(=O)c1cc(C=CC(=O)O)cc(C)c1N(C)S(=O)(=O)c1ccc(OC)cc1",
        "output": "158"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCBr.CN(C)C=O.O=C(O)c1ccccc1Nc1cccc(C(F)(F)F)c1.[K]>>CCCCOC(=O)c1ccccc1Nc1cccc(C(F)(F)F)c1",
        "output": "416"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)OB(c2ccccc2N)OC1(C)C.CS(=O)(=O)Cl.c1ccncc1>>CC1(C)OB(c2ccccc2NS(C)(=O)=O)OC1(C)C",
        "output": "194"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.CN(C)C=O.CO.COc1cc2c(Cl)cnnc2cc1O.Cl.ClCCCN1CCOCC1.O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>COc1cc2c(Cl)cnnc2cc1OCCCN1CCOCC1",
        "output": "74"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCCCO.CN(C)c1ccncc1.Cl.Cn1c(CCCC(=O)O)nc2cc(N(CCCl)CCCl)ccc21>>CCCCOC(=O)CCCc1nc2cc(N(CCCl)CCCl)ccc2n1C",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCBr.CCC(C)=O.O=C([O-])[O-].O=[N+]([O-])c1cccc(O)c1.[K+].[K+]>>O=[N+]([O-])c1cccc(OCCCBr)c1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CCOC(=O)CBr.COc1cc(-c2cc(=Nc3c(C)cc(C)cc3C)n(C)c(=O)n2C)ccc1O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)COc1ccc(-c2cc(=Nc3c(C)cc(C)cc3C)n(C)c(=O)n2C)cc1OC",
        "output": "123"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCCCCCCCCC1(CCCCCCCCCC)c2cc(Br)ccc2-c2ccc(Br)cc21.CN(C)C=O.Cc1ccccc1.Cl.[Li]CCCC>>CCCCCCCCCCC1(CCCCCCCCCC)c2cc(Br)ccc2-c2ccc(C=O)cc21",
        "output": "638"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.C[Si](C)(C)C=[N+]=[N-].Cc1ccccc1.O=C(O)C(Br)c1ccccc1Cl>>COC(=O)C(Br)c1ccccc1Cl",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)c1ccncc1.COc1cc2nccc(Cl)c2cc1OC.Cc1ccc(O)c(C(=O)c2ccccc2)c1.Clc1ccccc1Cl>>COc1cc2nccc(Oc3ccc(C)cc3C(=O)c3ccccc3)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.ClCCCl.N[C@@H]1CC[C@@H](c2ccccc2)CC1.O=C(O)CCc1ccc(O)cc1.On1nnc2ccccc21>>O=C(CCc1ccc(O)cc1)N[C@@H]1CC[C@@H](c2ccccc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCN(Cc2cc([N+](=O)[O-])cc(C(C)(C)C#N)c2)CC1.CO.[Pd]>>CN1CCN(Cc2cc(N)cc(C(C)(C)C#N)c2)CC1",
        "output": "71"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COc1cccc(C2C(C(=O)O)CC(=O)N2c2ccccc2)c1.FB(F)F>>COC(=O)C1CC(=O)N(c2ccccc2)C1c1cccc(OC)c1",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COc1cc([N+](=O)[O-])ccc1OCCN1CCC(OC)CC1.ClCCl>>COc1cc(N)ccc1OCCN1CCC(OC)CC1",
        "output": "202"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)Cn1cc(C(=O)N2CCN(c3ccccc3C(C)(C)C)CC2)nc1C.Cl.[Li+].[OH-]>>Cc1nc(C(=O)N2CCN(c3ccccc3C(C)(C)C)CC2)cn1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1.NN.O>>COc1ccccc1N1CCN(CCCCN)CC1",
        "output": "242"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCN(CCN)CC1.COc1cc(Nc2cc(Oc3ccc(NC(=O)OC(C)(C)C)c4ccccc34)ccn2)cc(C(=O)O)c1.F[P-](F)(F)(F)(F)F>>COc1cc(Nc2cc(Oc3ccc(NC(=O)OC(C)(C)C)c4ccccc34)ccn2)cc(C(=O)NCCN2CCN(C)CC2)c1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CN[C@H](CN2CCCC2)C1.CCN(CC)CC.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(OCCO)cc1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>O=C(c1ccc(OCCO)cc1)N1CCC[C@H]1CN1CCCC1",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)C(=O)c1ccc(OCCOc2cccc3ccccc23)cc1.[Na+].[OH-]>>O=C(O)C(=O)c1ccc(OCCOc2cccc3ccccc23)cc1",
        "output": "506"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1cc(/C=C/C(=O)N2CCNCC2)cc(C)c1Oc1ccc(O)cn1.Cc1ccc(OC/C=C/c2ccc(CCl)c(C)c2)cc1>>Cc1ccc(OC/C=C/c2ccc(CN3CCN(C(=O)/C=C/c4cc(C)c(Oc5ccc(O)cn5)c(C)c4)CC3)c(C)c2)cc1",
        "output": "156"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=S(=O)(Cl)c1ccc(Cl)cc1.c1ccc(C2CCCN2)cc1>>O=S(=O)(c1ccc(Cl)cc1)N1CCCC1c1ccccc1",
        "output": "900"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)c1cc(N[C@H]2CC[C@@H](CNC(=O)OCc3ccccc3)CC2)nc2ccccc12.CO.[Pd]>>CN(C)c1cc(N[C@H]2CC[C@@H](CN)CC2)nc2ccccc12",
        "output": "574"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.N#CCBr.N#CCc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>N#CCOc1ccc(CC#N)cc1",
        "output": "802"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CC(=O)Cl.CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN3CCC[C@@H](N)C3)c2n1.CO.ClCCl>>C=CC(=O)N[C@@H]1CCCN(CCn2c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)C1",
        "output": "298"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)n1nc(-c2ccccc2)c2ccc(N)cc21.ClCCl.Fc1ccccc1Br.O.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)OC(=O)n1nc(-c2ccccc2)c2ccc(Nc3ccccc3F)cc21",
        "output": "405"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCCCC1.CO.ClCCl.N.O=C1Nc2ccccc2CN1C1CCN(C2CCN(Cc3ccccc3)CC2)CC1.[OH-].[OH-].[Pd+2]>>O=C1Nc2ccccc2CN1C1CCN(C2CCNCC2)CC1",
        "output": "84"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)OB(c2cccc(N)c2)OC1(C)C.CS(=O)(=O)Cl>>CC1(C)OB(c2cccc(NS(C)(=O)=O)c2)OC1(C)C",
        "output": "194"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)CCCOc1ccc(N)cc1-c1ccnn1C.ClCCl.O=C=Nc1ccccc1Cl>>CN(C)CCCOc1ccc(NC(=O)Nc2ccccc2Cl)cc1-c1ccnn1C",
        "output": "804"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.Cc1ccc(S(=O)(=O)O)cc1.Nc1nc(N)c(C(=O)/N=C2\\NCC3(CCN(C(=O)c4cccc5c4ccn5CCOC4CCCCO4)CC3)N2)nc1Cl.O>>Nc1nc(N)c(C(=O)/N=C2\\NCC3(CCN(C(=O)c4cccc5c4ccn5CCO)CC3)N2)nc1Cl",
        "output": "543"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CC(C)O.CCN(C(C)C)C(C)C.Clc1ccn2ncc(Br)c2n1.O>>CC(C)(C)OC(=O)N1CCN(c2ccn3ncc(Br)c3n2)CC1",
        "output": "162"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C(=O)OC(C)(C)C)[C@H](Cc1ccc2ccccc2c1)C(=O)O.CN[C@H](Cc1ccccc1)C(=O)N(C)N(C)C.Cl.ClCCl.On1nnc2cccnc21>>CN(C(=O)OC(C)(C)C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N(C)N(C)C",
        "output": "297"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCN.CCOC(C)=O.Nc1nc(Cl)nc2c1ncn2C1CCCCO1.OCCO>>CCCCCNc1nc(N)c2ncn(C3CCCCO3)c2n1",
        "output": "578"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(C)=O.O=C(O)c1ccc([N+](=O)[O-])cn1.O=C([O-])O.O=S(=O)(O)O.[Na+]>>CCOC(=O)c1ccc([N+](=O)[O-])cn1",
        "output": "331"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CN.O=C(O)c1ccc2ccn(C3CCN(C(=O)OCc4ccccc4)CC3)c2c1.O=C(n1ccnc1)n1ccnc1>>CNC(=O)c1ccc2ccn(C3CCN(C(=O)OCc4ccccc4)CC3)c2c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)C1CCCC1.O=C1N[C@@H]2CCCC[C@H]2N1C1CCN(C2CCNCC2)CC1>>O=C(C1CCCC1)N1CCC(N2CCC(N3C(=O)N[C@@H]4CCCC[C@H]43)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.N#Cc1cnc2ccc(N)cc2c1Nc1ccc(F)c(Cl)c1.O=C1CCCC1c1ccccn1.[BH3-]C#N.[Na+]>>N#Cc1cnc2ccc(NC3CCCC3c3ccccn3)cc2c1Nc1ccc(F)c(Cl)c1",
        "output": "469"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCn1c(=O)c(NC(=O)Nc2c(C(C)C)cccc2C(C)C)c(-c2cccc(OCCCCl)c2)c2cccnc21.CN(C)C=O.O.O=C([O-])[O-].[I-].[K+].[K+].[Na+].c1c[nH]cn1>>CCCCn1c(=O)c(NC(=O)Nc2c(C(C)C)cccc2C(C)C)c(-c2cccc(OCCCn3ccnc3)c2)c2cccnc21",
        "output": "611"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N(CC=O)Cc1ccc2c(c1)OCO2.CNC(=O)C1CCNC1c1cc(C)nc(-n2ccnc2)n1.COC(OC)OC.O.[BH3-]C#N.[Na+]>>CNC(=O)C1CCN(CCN(Cc2ccc3c(c2)OCO3)C(=O)OC(C)(C)C)C1c1cc(C)nc(-n2ccnc2)n1",
        "output": "484"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=C(C)CN1C(=O)CC[C@H]1C(=O)O.CCN=C=NCCCN(C)C.Cl.ClCCl.NCc1ccc(F)cc1Cl.On1nnc2ccccc21>>C=C(C)CN1C(=O)CC[C@H]1C(=O)NCc1ccc(F)cc1Cl",
        "output": "797"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)C1CC1C(F)(F)F.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCC1CC1C(F)(F)F",
        "output": "225"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)NC1C2CC3(O)CC1CC(O)(C2)C3.Cl>>NC1C2CC3(O)CC1CC(O)(C2)C3",
        "output": "412"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COCCOC.Cc1nc(CC2CCN(c3ncc(Br)cn3)CC2)nc(C(=O)OC(C)(C)C)c1OCc1ccccc1.ClCCl.Cl[Pd]Cl.O.O=P([O-])([O-])[O-].OB(O)c1ccccc1.[Fe+2].[K+].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1nc(CC2CCN(c3ncc(-c4ccccc4)cn3)CC2)nc(C(=O)OC(C)(C)C)c1OCc1ccccc1",
        "output": "871"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.O.O=C(C1COc2ccccc2O1)N1CCNCC1.O=C([O-])[O-].O=Cc1cccc(F)c1F.[K+].[K+]>>O=Cc1cccc(F)c1N1CCN(C(=O)C2COc3ccccc3O2)CC1",
        "output": "868"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C(=O)Cl)CCCCC1.CCN(CC)CC.NCCN1CCN(c2ncccn2)CC1>>CC1(C(=O)NCCN2CCN(c3ncccn3)CC2)CCCCC1",
        "output": "45"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CC(=O)Nc1ccc2c(c1)NC(=O)C2.CCO.CCOC(C)=O.O=Cc1ccc(OCCN2CCOCC2)c(C2CCCCC2)c1>>CC(=O)Nc1ccc2c(c1)NC(=O)C2=Cc1ccc(OCCN2CCOCC2)c(C2CCCCC2)c1",
        "output": "439"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C1CCNCC1.FC(F)(F)c1ccc(Br)cc1>>CCOC(=O)C1CCN(c2ccc(C(F)(F)F)cc2)CC1",
        "output": "294"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(CCc1ccccc1)CC(F)(F)C(=O)N2C.NC1CCOCC1>>COc1cc(C(=O)NC2CCOCC2)ccc1Nc1ncc2c(n1)N(CCc1ccccc1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(F)cc2Cl)n(-c2ccccc2)n1.Cl.[Na+].[OH-]>>O=C(O)c1cc(NC(=O)c2cc(-c3ccccn3)c(F)cc2Cl)n(-c2ccccc2)n1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.ClCCl.O=S(Cl)Cl.OCc1ccc(-c2noc(-c3ccc(-c4ccccc4)c(F)c3)n2)cc1>>Fc1cc(-c2nc(-c3ccc(CCl)cc3)no2)ccc1-c1ccccc1",
        "output": "81"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=C(O)Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1.O=S(=O)(O)O>>COC(=O)Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1ccc(N2CCN(CC(=O)O)CC2)cc1.Cl.N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1>>CC(=O)c1ccc(N2CCN(CC(=O)N[C@@H](COCc3ccccc3)C(=O)Nc3ccc(Oc4ccc(F)cc4)cc3)CC2)cc1",
        "output": "133"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)c1ccc(S(=O)(=O)Nc2ccc(CC#N)nc2)cc1.CCO.N.[Ni]>>CC(C)c1ccc(S(=O)(=O)Nc2ccc(CCN)nc2)cc1",
        "output": "246"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.CI.ClCCl.N.O.O=C([O-])[O-].Oc1ccc(Br)cc1Cc1ccccc1.[K+].[K+]>>COc1ccc(Br)cc1Cc1ccccc1",
        "output": "62"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CI.COCCCN1C(=O)COc2ccc(COC3CN(C(=O)OCc4ccccc4)CCC3c3ccc(OC[C@H](O)COc4ccccc4)cc3)cc21.[H-].[Na+]>>COCCCN1C(=O)COc2ccc(COC3CN(C(=O)OCc4ccccc4)CCC3c3ccc(OC[C@@H](COc4ccccc4)OC)cc3)cc21",
        "output": "140"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCCCCCCCCCCCCC(=O)O.ClCCCl.O=C(Cl)C(=O)Cl>>CCCCCCCCCCCCCCCCCC(=O)Cl",
        "output": "56"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCOC(C)=O.Cc1ccccc1.Cl.Cl.N#CCc1cc(Cl)ccc1Br.[N-]=[N+]=[N-].[Na+]>>Clc1ccc(Br)c(Cc2nn[nH]n2)c1",
        "output": "366"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(CN(Cc3ncc[nH]3)Cc3ncc[nH]3)cc2)CC1.CO.Cl>>O=C(c1ccc(CN(Cc2ncc[nH]2)Cc2ncc[nH]2)cc1)N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.CS(=O)(=O)c1ccc(CBr)cc1.FC(F)(F)Cc1nc2cc(Cl)c(Cl)cc2[nH]1.O=C([O-])[O-].[K+].[K+]>>CS(=O)(=O)c1ccc(Cn2c(CC(F)(F)F)nc3cc(Cl)c(Cl)cc32)cc1",
        "output": "658"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)c1ccc2nc(-c3ccccc3)c(Cl)nc2c1.CS(C)=O.Cc1ccccc1.NCCc1ccccc1Br.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc2nc(-c3ccccc3)c(NCCc3ccccc3Br)nc2c1",
        "output": "148"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)N1CC[C@H](N)C1.CCOCC.ClCCl.O=CO.Oc1c(F)c(F)c(F)c(F)c1F>>CC(C)(C)OC(=O)N1CC[C@H](NC=O)C1",
        "output": "370"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CN1CCCN(c2ccc([N+](=O)[O-])cn2)CC1.[Pd]>>CN1CCCN(c2ccc(N)cn2)CC1",
        "output": "269"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CN(C)C=O.Cc1cc(C(=O)c2cc(Cl)ncn2)cc2c1NC(=O)C2.O.O=c1[nH]c2ncccc2n1C1CCNCC1>>Cc1cc(C(=O)c2cc(N3CCC(n4c(=O)[nH]c5ncccc54)CC3)ncn2)cc2c1NC(=O)C2",
        "output": "162"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(C(C)C)C(C)C.Cc1ccc(N2CCNCC2)cc1C.O=CCCc1cc(-c2ccc(F)cc2)n(-c2ccccc2)n1.[Na+]>>Cc1ccc(N2CCN(CCCc3cc(-c4ccc(F)cc4)n(-c4ccccc4)n3)CC2)cc1C",
        "output": "484"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)c1ccc2c(c1)C(C)NCC2.O=C(O)c1cc2ncc(Br)cn2n1>>CCN(CC)c1ccc2c(c1)C(C)N(C(=O)c1cc3ncc(Br)cn3n1)CC2",
        "output": "952"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClC(Cl)(Cl)Cl.ClCCl.O=C(O)c1ccc(N(CCCl)CCCl)cc1.O=S(Cl)Cl.c1ccccc1>>O=C(Cl)c1ccc(N(CCCl)CCCl)cc1",
        "output": "3"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O[C@@H](c1ccccc1)C1CCOCC1>>CS(=O)(=O)O[C@@H](c1ccccc1)C1CCOCC1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1ccc2c(c1)CCN2C(=O)c1ccccc1.O.O.[Li]O>>O=C(O)c1ccc2c(c1)CCN2C(=O)c1ccccc1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)N1CCN(C(=O)[C@H]2CCNC2)CC1.CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.CO.COCCOC.Cc1noc(-c2ccc(Br)cc2F)n1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>Cc1noc(-c2ccc(N3CC[C@H](C(=O)N4CCN(C(C)C)CC4)C3)cc2F)n1",
        "output": "294"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)COc1ccc(Sc2cc(C#Cc3ccc(S(C)(=O)=O)cc3)cc(Oc3ccc(C(F)(F)F)cn3)c2)cc1C.Cl.[Na+].[OH-]>>Cc1cc(Sc2cc(C#Cc3ccc(S(C)(=O)=O)cc3)cc(Oc3ccc(C(F)(F)F)cn3)c2)ccc1OCC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc2c(c1)c(C(=O)O)c(C)n2CCc1ccc(OC)c(OC)c1.O=C1OC2(CCNCC2)c2ccccc21>>COc1ccc2c(c1)c(C(=O)N1CCC3(CC1)OC(=O)c1ccccc13)c(C)n2CCc1ccc(OC)c(OC)c1",
        "output": "256"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1ccc(S(=O)(=O)Cl)c2ccccc12.O=C(O)C1CNc2ccccc21.O=C([O-])O.[Na+]>>COc1ccc(S(=O)(=O)N2CC(C(=O)O)c3ccccc32)c2ccccc12",
        "output": "791"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CC2CC1CN2.CCN(CC)CC.Cl.ClCCl.O=C(CBr)C1(c2ccc(Cl)c(Cl)c2)CCC1>>O=C(CN1CC2CCC1C2)C1(c2ccc(Cl)c(Cl)c2)CCC1",
        "output": "413"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.C[C@H](O)CN.N#Cc1cnc2cnc(F)cc2c1Nc1ccc(F)c(Cl)c1>>C[C@H](O)CNc1cc2c(Nc3ccc(F)c(Cl)c3)c(C#N)cnc2cn1",
        "output": "810"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)C1CNc2cc(Cl)c([N+](=O)[O-])c([N+](=O)[O-])c2O1.CN(C)c1ccncc1>>CCOC(=O)C1CN(C(=O)OC(C)(C)C)c2cc(Cl)c([N+](=O)[O-])c([N+](=O)[O-])c2O1",
        "output": "827"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@H](NC(=O)c1ncc[nH]1)C(=O)OC(C)(C)C.Cc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>C[C@H](NC(=O)c1ncc[nH]1)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cc1ccccc1.Cl[Pd]Cl.O=C(O)c1n[nH]c2cc(Cl)c(Br)cc12.O=C([O-])[O-].OCc1ccc(B(O)O)cc1.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=C(O)c1n[nH]c2cc(Cl)c(-c3ccc(CO)cc3)cc12",
        "output": "837"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCI.COc1c(N2CCCC(=C(F)CNC(=O)OC(C)(C)C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)c1cn(C2CC2)c2c(OC)c(N3CCCC(=C(F)CNC(=O)OC(C)(C)C)C3)c(F)cc2c1=O",
        "output": "196"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCc1ccc2nc(COc3ccc(F)c(C(N)=O)c3F)sc2n1.CO.[Pd]>>CCCc1ccc2nc(COc3ccc(F)c(C(N)=O)c3F)sc2n1",
        "output": "116"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)O.CCCCOc1cc(/C=C(\\OCC)C(=O)OC)ccc1-c1cccc(N(C)C(=O)NCCc2ccccc2)c1.CO.O.O.[Li+].[OH-]>>CCCCOc1cc(/C=C(\\OCC)C(=O)O)ccc1-c1cccc(N(C)C(=O)NCCc2ccccc2)c1",
        "output": "58"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3[C@@H](OC(=O)CI)C[C@]12C.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](OS(C)(=O)=O)CC[C@]4(C)[C@H]3[C@@H](OC(=O)CI)C[C@]12C",
        "output": "0"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.O.O=C([O-])[O-].OCCCBr.Oc1ccc(Br)cc1.[Cl-].[K+].[K+].[NH4+]>>OCCCOc1ccc(Br)cc1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1ccccc1C(=O)O.O=Cc1ccc2c(c1)CCO2>>O=C(O)c1ccccc1NCc1ccc2c(c1)CCO2",
        "output": "359"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.O=C1CCC(=O)N1Cl.O=[N+]([O-])c1ccc(Cl)nc1NCC(F)(F)F>>O=[N+]([O-])c1cc(Cl)c(Cl)nc1NCC(F)(F)F",
        "output": "743"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.CS(=O)(=O)c1cc(C(=O)O)ccc1N.O=S(Cl)Cl>>COC(=O)c1ccc(N)c(S(C)(=O)=O)c1",
        "output": "33"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)CN(C)C(=O)Nc1cc(-c2ccccc2OC)ncn1.O.[Li+].[OH-]>>COc1ccccc1-c1cc(NC(=O)N(C)CC(=O)O)ncn1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN(C)C=O.COC(=O)c1cc(Cl)cc2c1c(C)cn2C(C)C.ClCCl.O=C1CCC(=O)N1Br>>COC(=O)c1cc(Cl)cc2c1c(C)c(Br)n2C(C)C",
        "output": "779"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C(=O)Nc1ccc2ncccc2c1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.CI.CN(C)C=O.[H-].[Na+]>>CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc2ncccc2c1-c1ccccc1",
        "output": "237"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)[O-].Clc1ccccc1.NCCCCNc1ccccc1.[Na+]>>c1ccc(NCCCCNc2ccccc2)cc1",
        "output": "304"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)CCN.Nc1ncc(-c2nc(N3CCOCC3)c3sc(-c4ccnc(F)c4)cc3n2)cn1>>CS(=O)(=O)CCNc1cc(-c2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)ccn1",
        "output": "810"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1cccc(-c2c(Cc3ccccc3)cnc3c(C(F)(F)F)cccc23)c1.O=Cc1c(Cl)ccc(Cl)c1Cl>>FC(F)(F)c1cccc2c(-c3cccc(NCc4c(Cl)ccc(Cl)c4Cl)c3)c(Cc3ccccc3)cnc12",
        "output": "359"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.C1COCCO1.COC(=O)C1CCOc2cc(Oc3ccc(C(=O)NCCc4ccc(C(F)(F)F)cn4)cc3)c(C#N)cc21.Cl.O.O.[Li+].[OH-]>>N#Cc1cc2c(cc1Oc1ccc(C(=O)NCCc3ccc(C(F)(F)F)cn3)cc1)OCCC2C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)C1CN(C(=O)OC(C)(C)C)c2cc(Cl)c([N+](=O)[O-])cc2O1.O.[Cl-].[NH4+].[Zn]>>CCOC(=O)C1CN(C(=O)OC(C)(C)C)c2cc(Cl)c(N)cc2O1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)n1cccc1-c1cnc(N)c(OCc2c(Cl)cccc2Cl)c1.CCO.O.O=C([O-])[O-].[Na+].[Na+]>>Nc1ncc(-c2ccc[nH]2)cc1OCc1c(Cl)cccc1Cl",
        "output": "848"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1c(CC)nc2c(cnn2CC)c1NC1CCOCC1.CO.Cl.O.O.[Cl-].[Li+].[Na+].[OH-]>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.ClCCl.N#Cc1c[nH]c(-c2nc([C@H]3CCCNC3)no2)c1.O=C(O)c1ccnc(F)c1.On1nnc2cccnc21>>N#Cc1c[nH]c(-c2nc([C@H]3CCCN(C(=O)c4ccnc(F)c4)C3)no2)c1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CCCCCCCCCCCCCCCCOC(=O)Cl.Cc1ccccc1.Nc1ccn(C2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1.O=C([O-])O.[Na+]>>CCCCCCCCCCCCCCCCOC(=O)Nc1ccn(C2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1",
        "output": "502"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CCCCCCCc1nc(-c2ccccn2)no1.CO.[Na+].[OH-]>>O=C(O)CCCCCCCc1nc(-c2ccccn2)no1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.C1COCCO1.Cc1ccc(N(c2ccc(C)cc2)c2c3ccccc3cc3ccccc23)cc1.O.O=S([O-])([O-])=S.[K+].[Na+].[Na+].[OH-]>>Cc1ccc(N(c2ccc(C)cc2)c2c3ccccc3c(Br)c3ccccc23)cc1",
        "output": "98"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.CS(=O)(=O)c1ccc(O)cn1.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c(F)c1OCc1ccccc1.[K+].[K+]>>CS(=O)(=O)c1ccc(Oc2ccc([N+](=O)[O-])c(OCc3ccccc3)c2F)cn1",
        "output": "845"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.COC(=O)c1ccnc(N2CCNCC2)c1.ClCCl.O=C(Cl)c1cc(F)ccc1C(F)(F)F>>COC(=O)c1ccnc(N2CCN(C(=O)c3cc(F)ccc3C(F)(F)F)CC2)c1",
        "output": "201"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.ClCCl.Nc1cc(F)ccc1F>>CC(=O)Nc1cc(F)ccc1F",
        "output": "6"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCCCC(C=Cc1ccc(C(=O)OC)cc1)c1ccc2c(c1)OCCC2(C)C.CO.O.O.[Li+].[OH-]>>CCCCCC(C=Cc1ccc(C(=O)O)cc1)c1ccc2c(c1)OCCC2(C)C",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccccc1.Cc1cc(C)cc(-c2c(OCCC3CCCCN3C(=O)OC(C)(C)C)c3cc(C(=O)N4CCCC4)c(Cl)cc3[nH]c2=O)c1.O=C(O)C(F)(F)F>>Cc1cc(C)cc(-c2c(OCCC3CCCCN3)c3cc(C(=O)N4CCCC4)c(Cl)cc3[nH]c2=O)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1cccc(C(C)(C)C)n1.CCOC(C)=O.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)c1cccc(C(C)(C)C)[n+]1[O-]",
        "output": "262"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC12CCC3CC31CN(C(=O)OCc1ccccc1)C2.CO.[C].[H][H].[Pd]>>CC(C)(C)OC(=O)NC12CCC3CC31CNC2",
        "output": "428"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CO.COC(OC)OC.NCCCCNC(=O)c1ccc(CN(Cc2ncc[nH]2)Cc2ncc[nH]2)cc1.O=C1CCCCCC1.[BH3-]C#N.[Na+]>>O=C(NCCCCNC1CCCCCC1)c1ccc(CN(Cc2ncc[nH]2)Cc2ncc[nH]2)cc1",
        "output": "236"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)c1cc(-c2ccc(OCc3ccccc3)cn2)n(-c2ccc(C)nc2)n1.CCOC(C)=O.[H][H].[Pd]>>CCOC(=O)c1cc(-c2ccc(O)cn2)n(-c2ccc(C)nc2)n1",
        "output": "264"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC(CN)(C2CCCCC2)CC1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)N1CCC(CNS(C)(=O)=O)(C2CCCCC2)CC1",
        "output": "493"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cn1c(C(C)(C)NC(=O)OCc2ccccc2)nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O.[Pd]>>Cn1c(C(C)(C)N)nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O",
        "output": "574"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.CNC(=O)c1cccc(F)c1Nc1nc(Cl)ncc1Cl.COCCN1C(=O)CCCc2cc(N)ccc21.O>>CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)CCCC(=O)N3CCOC)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COCCOC.O=C(O)c1cc(Cl)c(O)c(Cl)c1.O=S(Cl)Cl>>O=C(Cl)c1cc(Cl)c(O)c(Cl)c1",
        "output": "3"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)C1CN(C(=O)OC(C)(C)C)CC(F)(F)C1.ClCCl.[BH4-].[Na+]>>CC(C)(C)OC(=O)N1CC(CO)CC(F)(F)C1",
        "output": "343"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCc1ccc(C2CC(C(=O)O)CN(C(=O)C3CCCC3)C2)cc1.NC(Cc1ccccc1Cl)=NO>>CCc1ccc(C2CC(c3nc(Cc4ccccc4Cl)no3)CN(C(=O)C3CCCC3)C2)cc1",
        "output": "728"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CI.C[C@H]1C[C@H](C(=O)O)N(C(=O)OC(C)(C)C)C1.O=C([O-])[O-].[K+].[K+]>>COC(=O)[C@H]1C[C@H](C)CN1C(=O)OC(C)(C)C",
        "output": "415"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)O.COC(OC)C(CNC(=O)OC(C)(C)C)SCc1ccccc1.O>>CC(C)(C)OC(=O)NCC(C=O)SCc1ccccc1",
        "output": "234"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.CCN(CC)CC.CNC1CCC2(C)C(=CCC3C2CCC24CN(C)C(C)C2CCC34)C1.ClCCl>>CC(=O)N(C)C1CCC2(C)C(=CCC3C2CCC24CN(C)C(C)C2CCC34)C1",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "NC12CC3CC(CC(C3)C1)C2.O=Cc1c(F)c(F)c(O)c(F)c1F>>Oc1c(F)c(F)c(CNC23CC4CC(CC(C4)C2)C3)c(F)c1F",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCc1cnc(Cl)nc1.Cc1nc(OCCCC2CCNCC2)ccc1C(=O)NC[C@H](O)CO>>CCc1cnc(N2CCC(CCCOc3ccc(C(=O)NC[C@H](O)CO)c(C)n3)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC1CCCN1.CCOC(C)=O.Cc1nc(-c2ccc(OCCCCl)cc2)sc1C(=O)N1CCOCC1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>Cc1nc(-c2ccc(OCCCN3CCCC3C)cc2)sc1C(=O)N1CCOCC1",
        "output": "138"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC1(CC)OB(O)c2cc(CN)ccc21.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)n2cccc12>>CCC1(CC)OB(O)c2cc(CNC(=O)c3ccc(C4=NOC(c5cc(Cl)c(Cl)c(Cl)c5)(C(F)(F)F)C4)n4cccc34)ccc21",
        "output": "790"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(CC2(C(=O)O)CCN(Cc3ccccc3)CC2)cc1.CS(=O)(=O)O.O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3.[Na+].[OH-]>>COc1ccc2c(c1)C(=O)C1(CCN(Cc3ccccc3)CC1)C2",
        "output": "274"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)[C@@H](N)Cc1ccc(NC(=O)c2c(C)cccc2Cl)cc1.O=C(O)c1c(Cl)cccc1Cl>>COC(=O)[C@H](Cc1ccc(NC(=O)c2c(C)cccc2Cl)cc1)NC(=O)c1c(Cl)cccc1Cl",
        "output": "652"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(OC)OC.NCCCO.O=Cc1cccc([N+](=O)[O-])c1.[BH4-].[Na+]>>O=[N+]([O-])c1cccc(CNCCCO)c1",
        "output": "468"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)NC[C@H]3CCCCN3C(=O)OC(C)(C)C)n2c1.Cl.O=C(O)C(F)(F)F>>Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)NC[C@H]3CCCCN3)n2c1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(CCCc1ccc(Br)cc1)C(=O)Nc1cccc(C#N)c1.CNCCc1ccc(Br)cc1.N#Cc1cccc(N=C=O)c1>>CN(CCc1ccc(Br)cc1)C(=O)Nc1cccc(C#N)c1",
        "output": "323"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCc1nc2c(F)ccc(OCC(=O)OC)c2c(OC(F)F)c1Cc1ccc(NS(=O)(=O)CC)cc1.CO.O.[Na+].[OH-]>>CCc1nc2c(F)ccc(OCC(=O)O)c2c(OC(F)F)c1Cc1ccc(NS(=O)(=O)CC)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CBr.CN(C)C=O.O.O=C([O-])[O-].O=Cc1ccc(O)cc1.[K+].[K+]>>CCOC(=O)COc1ccc(C=O)cc1",
        "output": "123"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccccc1OC.O=C1CCC(=O)O1.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(C(=O)CCC(=O)O)cc1OC",
        "output": "345"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCN(C(=O)c2cccc(Nc3c(Cl)c(=O)c3=O)c2O)CC1.CS(C)=O.Nc1ccc(F)cc1Cl>>CN1CCN(C(=O)c2cccc(Nc3c(Nc4ccc(F)cc4Cl)c(=O)c3=O)c2O)CC1",
        "output": "510"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNC1.Fc1cc(F)c(F)c(Br)c1>>Fc1cc(F)c(N2CCCC2)c(Br)c1",
        "output": "26"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)C1CCN(C(=O)OC(C)(C)C)C1c1cc([N+](=O)[O-])ccc1S(=O)(=O)C(C)C.[Pd]>>COC(=O)C1CCN(C(=O)OC(C)(C)C)C1c1cc(N)ccc1S(=O)(=O)C(C)C",
        "output": "71"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)c1ccc(OCc2c(-c3ccccc3)noc2C)nc1.COC(=O)c1ccc(OCc2conc2-c2ccc(Cl)cc2)nc1.NC(CO)CO>>O=C(NC(CO)CO)c1ccc(OCc2conc2-c2ccc(Cl)cc2)nc1",
        "output": "862"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Nc1ccc(Cl)cc1O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c(Cl)c1.[K+].[K+]>>Nc1ccc(Cl)cc1Oc1ccc([N+](=O)[O-])cc1Cl",
        "output": "564"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1Cc2c(N)n[nH]c2C1(C)C.CCN(C(C)C)C(C)C.C[Si](C)(C)CCOCCl>>CC(C)(C)OC(=O)N1Cc2c(N)nn(COCC[Si](C)(C)C)c2C1(C)C",
        "output": "910"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)c1cccc(C2(NC[C@@H](O)[C@@H](N)Cc3ccc(Nc4cc(-c5ccccc5)ncn4)cc3)CC2)c1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.COCC(=O)O.Cl>>COCC(=O)N[C@@H](Cc1ccc(Nc2cc(-c3ccccc3)ncn2)cc1)[C@H](O)CNC1(c2cccc(C(C)(C)C)c2)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1onc(-c2ccccc2)c1-c1c[nH]cn1.Fc1ccc(C(F)(F)F)cc1>>Cc1onc(-c2ccccc2)c1-c1cn(-c2ccc(C(F)(F)F)cc2)cn1",
        "output": "701"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.CCOC(C)=O.CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2cc(CN3CC[C@@H](N)C3)c(OC(F)(F)F)cc2c1=O.ClCCl.[Cl-].[NH4+].c1ccncc1>>CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2cc(CN3CC[C@@H](NC(C)=O)C3)c(OC(F)(F)F)cc2c1=O",
        "output": "45"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCOC(=O)c1c(C)nc(NCCCc2cccc(O)c2F)nc1C.O.O.[Li+].[OH-]>>Cc1nc(NCCCc2cccc(O)c2F)nc(C)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCOCCCCCCN1CCC(=O)CC1.Cl.NO>>CCCOCCCCCCN1CCC(=NO)CC1",
        "output": "86"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COC1(CC#N)CCNCC1.Cl.Nc1ccnc(Cl)n1>>COC1(CC#N)CCN(c2nccc(N)n2)CC1",
        "output": "36"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.C[Si](C)(C)C=[N+]=[N-].ClCCl.O=C1CC(C(=O)O)C1>>COC(=O)C1CC(=O)C1",
        "output": "195"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(CC(=O)O)CC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CS(=O)(=O)c1ccc(N2CCNCC2)cc1.O.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCC(CC(=O)N2CCN(c3ccc(S(C)(=O)=O)cc3)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cc1ccc(NC(=O)OC(C)(C)C)cc1[N+](=O)[O-].[Pd]>>Cc1ccc(NC(=O)OC(C)(C)C)cc1N",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCC(CCCN2CCNCC2)CC1.COc1ccc(Br)cc1C.Fc1cc(Br)ccc1OCc1ccccc1.c1ccc(CCN2CCNCC2)cc1>>Fc1cc(N2CCN(CCCC3CCCCC3)CC2)ccc1OCc1ccccc1",
        "output": "294"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CC(CC(C)C)C(=O)O.CN1CCOCC1.ClCCCl.NCc1ccc(-c2ccccc2)cc1.On1nnc2ccccc21>>CCOC(=O)CC(CC(C)C)C(=O)NCc1ccc(-c2ccccc2)cc1",
        "output": "599"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1ccccc1S(N)(=O)=O.O=C(O)c1cccc(OCc2ccc(C(F)(F)F)cc2)c1.O=S(Cl)Cl.c1ccccc1>>NS(=O)(=O)c1ccccc1NC(=O)c1cccc(OCc2ccc(C(F)(F)F)cc2)c1",
        "output": "50"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-n2ccc(C(F)(F)F)n2)cn1.O.[Li+].[OH-]>>O=C(O)c1ccc(-n2ccc(C(F)(F)F)n2)cn1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C(Cc1ccc(OCCNC(=O)c2ccc(-c3ccc(F)cc3)cc2)cc1)Oc1ccc(C(C)C)cc1.[Na+].[OH-]>>CC(C)c1ccc(OC(Cc2ccc(OCCNC(=O)c3ccc(-c4ccc(F)cc4)cc3)cc2)C(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc(CCCCCCCCBr)cc1.ClCCl.O>>Oc1ccc(CCCCCCCCBr)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=CC(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.N#Cc1cnc2c(sc3ccc(N)cc32)c1Nc1cccc(Br)c1>>C=CC(=O)Nc1ccc2sc3c(Nc4cccc(Br)c4)c(C#N)cnc3c2c1",
        "output": "170"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Br.COc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1>>O=[N+]([O-])c1cc(O)cc([N+](=O)[O-])c1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cccc(-c2cc(-c3ccccn3)cn(-c3ccccc3)c2=O)n1.Cl>>O=c1c(-c2cccc(O)n2)cc(-c2ccccn2)cn1-c1ccccc1",
        "output": "408"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "FC(F)(F)c1cccc(CBr)c1Cl.N#Cc1ccnc(-c2c[nH]cn2)c1>>N#Cc1ccnc(-c2cn(Cc3cccc(C(F)(F)F)c3Cl)cn2)c1",
        "output": "658"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)CNc1c(F)cccc1F.Cc1noc(C)c1COc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>Cc1noc(C)c1COc1ccc(S(=O)(=O)N(CC(C)C)c2c(F)cccc2F)cc1",
        "output": "791"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)[C@H](CNC(=O)C1CCN(c2cccc(NC(=S)NCc3ccccc3)c2)CC1)NC(=O)OCc1ccccc1.O=C(O)C(F)(F)F.[Na+].[OH-]>>O=C(N[C@@H](CNC(=O)C1CCN(c2cccc(NC(=S)NCc3ccccc3)c2)CC1)C(=O)O)OCc1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O=c1ccccn1-c1ccc([N+](=O)[O-])cc1Cl.[Cl-].[NH4+].[Zn]>>Nc1ccc(-n2ccccc2=O)c(Cl)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CCO.O=[N+]([O-])c1ccccc1-n1cccc1.[Fe]>>Nc1ccccc1-n1cccc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N(c1cscn1)S(=O)(=O)c1cc(Cl)c(F)cc1F.CS(C)=O.Nc1cc(-c2cc(F)ccc2O)ccn1.O.O=C([O-])[O-].[Cl-].[K+].[K+].[NH4+]>>CC(C)(C)OC(=O)N(c1cscn1)S(=O)(=O)c1cc(Cl)c(Oc2ccc(F)cc2-c2ccnc(N)c2)cc1F",
        "output": "564"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCOC(C)=O.CO.COc1ccc(-c2nc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)cc(C)c2C)c(C)n1.C[Si](C)(C)I>>Cc1cc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc(-c2ccc(=O)[nH]c2C)c1C",
        "output": "758"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C(=O)O)c1ccc(CBr)cc1.CCO.O.[C-]#N.[K+]>>CC(C(=O)O)c1ccc(CC#N)cc1",
        "output": "39"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.CCO.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)ccc2Oc2cc(Cl)ncn2)cc1.O=C([O-])[O-].[Na+].[Na+]>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)ccc2Oc2cc(N3CCOCC3)ncn2)cc1",
        "output": "162"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.COC(=O)c1c(C)cc(Cl)nc1Cl.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COC(=O)c1c(CBr)cc(Cl)nc1Cl",
        "output": "29"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccccc1-c1ccc2c(c1)NC(=O)C2.Cc1cc(CCC(=O)O)c(C=O)[nH]1>>COc1ccccc1-c1ccc2c(c1)NC(=O)C2=Cc1[nH]c(C)cc1CCC(=O)O",
        "output": "440"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CSc1nc(Nc2cccc(OCc3ccccc3)c2)cc(N(C)C)n1.ClCCl.O=C(OO)c1cccc(Cl)c1>>CN(C)c1cc(Nc2cccc(OCc3ccccc3)c2)nc(S(C)=O)n1",
        "output": "595"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)c1nc(N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)ccc1CCCI.CCOC(=O)c1nc(N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)sc1CCCI.N#Cc1cscc1-c1ccc(OCCCc2sc(N3CCc4cccc(C(=O)Nc5nc6ccccc6s5)c4C3)nc2C(=O)O)cc1.O=C(O)C(F)(F)F.Oc1ccnc(Cl)c1>>CC(C)(C)OC(=O)c1nc(N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)ccc1CCCOc1ccnc(Cl)c1",
        "output": "198"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CO.O.O=C1c2ccccc2C(=O)N1CC=Cc1ccc(O)cc1.[Pd]>>O=C1c2ccccc2C(=O)N1CCCc1ccc(O)cc1",
        "output": "362"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)COc1ncc(Oc2ccc(C#N)cc2)cc1Cl.CCOC(C)=O.CS(C)=O.O=C([O-])[O-].OO.[K+].[K+]>>CC(C)COc1ncc(Oc2ccc(C(N)=O)cc2)cc1Cl",
        "output": "180"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)[Si](Cl)(C(C)C)C(C)C.CN(C)C=O.Cl.O=C(OCc1ccccc1)N1C[C@H](O)[C@@H](c2ccc(O)cc2)[C@H](CO)C1.c1c[nH]cn1>>CC(C)[Si](OC[C@@H]1CN(C(=O)OCc2ccccc2)C[C@H](O)[C@H]1c1ccc(O)cc1)(C(C)C)C(C)C",
        "output": "193"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1cccc([C@H](C)N)c1.COC(=O)COc1cccc(Cn2c(C)c(C)c3cc(C(=O)O)ccc32)c1.Cl>>COC(=O)COc1cccc(Cn2c(C)c(C)c3cc(C(=O)N[C@@H](C)c4cccc(C(C)C)c4)ccc32)c1",
        "output": "753"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C[C@H](CO)[C@H]1CC=C2C3=C(CC[C@@]21C)[C@@]1(C)CC[C@H](OC(=O)c2ccccc2)C(C)(C)[C@@H]1CC3.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>C[C@H](C=O)[C@H]1CC=C2C3=C(CC[C@@]21C)[C@@]1(C)CC[C@H](OC(=O)c2ccccc2)C(C)(C)[C@@H]1CC3",
        "output": "142"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1ccc(CC(=O)O)cc1.CCN(CC)CC.CCN=C=NCCCN(C)C.C[C@@H](N)c1ccc(Br)cn1.Cl.Cl.ClCCl.On1nnc2cccnc21>>CC(C)c1ccc(CC(=O)N[C@H](C)c2ccc(Br)cn2)cc1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.C[Si](C)(C)Cl.O=C(O)c1cc(O)c(Br)c(O)c1>>COC(=O)c1cc(O)c(Br)c(O)c1",
        "output": "33"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(CCl)cc1.CSc1nccc(-c2cn[nH]c2)n1.ClCCl.O>>COc1ccc(Cn2cc(-c3ccnc(SC)n3)cn2)cc1",
        "output": "842"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CC(N)C1.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(C)(F)C(=O)N2C.Cl.F[P-](F)(F)(F)(F)F>>COc1cc(C(=O)NC2CN(C)C2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(C)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.C[O-].O=C(O)c1cccc(CBr)c1.[Na+]>>COCc1cccc(C(=O)O)c1",
        "output": "464"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NC(=O)c1ccc2cncc(Br)c2n1.OB(O)c1ccc(Cl)c(F)c1>>NC(=O)c1ccc2cncc(-c3ccc(Cl)c(F)c3)c2n1",
        "output": "871"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCOC[C@H](NC(=O)OC(C)(C)C)C(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C.COC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C.Cl.O.O=C(O)C(F)(F)F.On1nnc2ccccc21>>C=CCOC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)OC)C(C)C)C(C)C",
        "output": "133"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C1C(c2ccccc2)=C1c1cccc(Cl)c1.CO.[K+].[OH-]>>O=C(O)C1C(c2ccccc2)=C1c1cccc(Cl)c1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CS(C)=O.O=C(NCc1cn(-c2ccc(-n3ccccc3=O)cc2N2CCNCC2)nn1)c1ccc(Cl)s1.c1ccncc1>>CC(=O)N1CCN(c2cc(-n3ccccc3=O)ccc2-n2cc(CNC(=O)c3ccc(Cl)s3)nn2)CC1",
        "output": "125"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC1CCCC(C(=O)O)C1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCc1cccc(Cl)c1>>CC(C)(C)OC(=O)NC1CCCC(C(=O)NCc2cccc(Cl)c2)C1",
        "output": "599"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[O-].CS(C)=O.C[C@]12CC[C@H]3C(=CCc4cc(O)ccc43)[C@@H]1CCC2=O.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-].[K+]>>C=C1CC[C@H]2C3=CCc4cc(O)ccc4[C@H]3CC[C@]12C",
        "output": "601"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CC(C)O.CCOC(C)=O.CN(C)C=O.O=C(Cl)c1ccc(F)cc1C(F)(F)F.O=C(O)c1ccc(F)cc1C(F)(F)F.O=S(Cl)Cl.c1ccncc1>>CC(C)OC(=O)c1ccc(F)cc1C(F)(F)F",
        "output": "33"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)c1cc2nnc(-c3ccccc3)n2nc1Cl.CN(C)C=O.Cn1cnc(CO)n1.O.[H-].[Na+]>>CCN(CC)c1cc2nnc(-c3ccccc3)n2nc1OCc1ncn(C)n1",
        "output": "407"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CC(C)c1nnc2ccc(-c3cn(C4CCNC4)nc3-c3ccc(F)cc3F)nn12.CCN(C(C)C)C(C)C.ClCCl>>CC(=O)N1CCC(n2cc(-c3ccc4nnc(C(C)C)n4n3)c(-c3ccc(F)cc3F)n2)C1",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cl[Sn]Cl.O.O.O=[N+]([O-])c1cccc(/C=C/c2cccc(OC(F)(F)F)c2)c1>>Nc1cccc(/C=C/c2cccc(OC(F)(F)F)c2)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(CCS(=O)(=O)CC(O)CO)NC(=O)OCc1ccccc1.CO.[H][H].[Pd]>>CC(C)(N)CCS(=O)(=O)CC(O)CO",
        "output": "574"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)C[C@H](NC(=O)[C@@H](NC(=O)CN1CCOCC1)C(C)(C)C)C(=O)OCc1ccccc1.CO.[OH-].[OH-].[Pd+2]>>CC(C)C[C@H](NC(=O)[C@@H](NC(=O)CN1CCOCC1)C(C)(C)C)C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)c(-c2ccnc(Cl)n2)s1.CCN(C(C)C)C(C)C.CO.ClCCl.NCCN1CCCC1=O>>CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)c(-c2ccnc(NCCN3CCCC3=O)n2)s1",
        "output": "544"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1cc(C)c(NC(=O)c2cc(-c3cccc(CO)c3)nc3ccccc23)c(C)c1.CO.Cl.[Na+].[OH-]>>Cc1cc(C(=O)O)cc(C)c1NC(=O)c1cc(-c2cccc(CO)c2)nc2ccccc12",
        "output": "5"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.C[C@@H](CO[Si](C)(C)C(C)(C)C)Nc1c([N+](=O)[O-])cnc2cc(Br)ccc12.[Pt]>>C[C@@H](CO[Si](C)(C)C(C)(C)C)Nc1c(N)cnc2cc(Br)ccc12",
        "output": "269"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cn(C(C)C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N.O=C(O)C(F)(F)F>>COc1cn(C(C)C(=O)Nc2ccc(C(=O)O)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N",
        "output": "752"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)O.Cl.ClCCl.O=[N+]([O-])c1ccc(OC2CCN(Cc3ccc(C(O)(C(F)(F)F)C(F)(F)F)cc3)CC2)c(Br)c1.[Fe]>>Nc1ccc(OC2CCN(Cc3ccc(C(O)(C(F)(F)F)C(F)(F)F)cc3)CC2)c(Br)c1",
        "output": "202"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.OCc1ccc(CCc2ccco2)cc1.[Mn+4].[O-2].[O-2]>>O=Cc1ccc(CCc2ccco2)cc1",
        "output": "179"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)Cl.Cl.NC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C2CC2)c1=O)c1ccccc1C(F)(F)F.c1ccncc1>>CS(=O)(=O)NC(CNC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C2CC2)c1=O)c1ccccc1C(F)(F)F",
        "output": "742"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(Oc1ccccc1Cl)C(=O)O.C[C@H]1C=CC2=C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O)[C@@H]2[C@H]1CC[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CC(=O)O1>>CC(Oc1ccccc1Cl)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O[Si](C)(C)C(C)(C)C)CC(=O)O3)[C@H]21",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#CC(CC(=O)OCC)c1ccc(N)cc1.CC(Oc1cccc(C(C)C)c1)C(=O)O.CCN1CCOCC1.CCN=C=NCCCN(C)C.CN(C)C=O.O.O.On1nnc2ccccc21>>CC#CC(CC(=O)OCC)c1ccc(NC(=O)C(C)Oc2cccc(C(C)C)c2)cc1",
        "output": "365"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1ncc2c(cc(-c3cnccn3)c(=O)n2Cc2ccccc2)c1O.C[O-].NCCC(=O)O.[Na+]>>O=C(O)CCNC(=O)c1ncc2c(cc(-c3cnccn3)c(=O)n2Cc2ccccc2)c1O",
        "output": "487"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cc1ccc(-c2c(CNC(=O)OC(C)(C)C)c(CC(C)C)nc(C)c2C(=O)O)cc1.Cl.On1nnc2ccccc21.[NH4+]>>Cc1ccc(-c2c(CNC(=O)OC(C)(C)C)c(CC(C)C)nc(C)c2C(N)=O)cc1",
        "output": "704"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc2nccc(Oc3ccc(CC(=O)O)cc3)c2cc1OC.COc1ccc(Cn2nc(N(C)C(=O)OC(C)(C)C)cc2N)cc1OC>>COc1ccc(Cn2nc(N(C)C(=O)OC(C)(C)C)cc2NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cc1OC",
        "output": "795"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.COC(=O)c1ccnc(N)c1.F[P-](F)(F)(F)(F)F.O=C(O)COc1cc(Cl)c(Cl)cc1Cl.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>COC(=O)c1ccnc(NC(=O)COc2cc(Cl)c(Cl)cc2Cl)c1",
        "output": "368"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC2=NCCCN2CC1.CN(C)C=O.ClC(c1ccccc1)(c1ccccc1)c1ccccc1.OCc1cc(Br)c(Br)o1>>Brc1cc(COC(c2ccccc2)(c2ccccc2)c2ccccc2)oc1Br",
        "output": "250"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCCC1C(=O)O.CI.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>COC(=O)C1CCCN1C(=O)OC(C)(C)C",
        "output": "415"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)O.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cc(N)ccc1Cl>>Cc1cc(NC(=O)OC(C)(C)C)ccc1Cl",
        "output": "735"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(Cc2[nH]c3cc(Cl)c(-c4ccc(-c5ccc(S(C)(=O)=O)cc5)cc4)cc3c2F)ccc1C.Cl.O.[Na+].[OH-]>>Cc1ccc(Cc2[nH]c3cc(Cl)c(-c4ccc(-c5ccc(S(C)(=O)=O)cc5)cc4)cc3c2F)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N[C@@H]1CCCC[C@H]1O.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CN[C@@H]1CCCC[C@H]1O",
        "output": "881"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(=O)(=O)Cl.Cc1cc(N2CCC(CCO)CC2)c2c(C)cn(-c3c(C)cc(Br)cc3C)c2n1.ClC(Cl)Cl.O.c1ccncc1>>Cc1cc(N2CCC(CCOS(C)(=O)=O)CC2)c2c(C)cn(-c3c(C)cc(Br)cc3C)c2n1",
        "output": "0"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CNC.ClCCl.O=C(O)c1cccc(S(=O)(=O)Cl)c1>>CN(C)S(=O)(=O)c1cccc(C(=O)O)c1",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)O[C@@H]1CO[C@@H]2[C@H](Oc3nc4cc(Cl)c(-c5ccc([C@@H]6CC[C@@H](O)CC6)cc5)nc4n3COCC[Si](C)(C)C)CO[C@@H]21.CC(C)N=C=O>>CC(C)NC(=O)O[C@@H]1CC[C@@H](c2ccc(-c3nc4c(cc3Cl)nc(O[C@@H]3CO[C@H]5[C@@H]3OC[C@H]5O[Si](C)(C)C(C)(C)C)n4COCC[Si](C)(C)C)cc2)CC1",
        "output": "235"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1N.CCOC(C)=O.COC(=O)c1c(C#N)cc(Cl)nc1-c1cnn(C)c1.O>>COC(=O)c1c(C#N)cc(N[C@@H]2CCCC[C@@H]2NC(=O)OC(C)(C)C)nc1-c1cnn(C)c1",
        "output": "70"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.ClCCl.NCC1CCN(c2nccc(/C=C3\\NC(=O)NC3=O)n2)CC1.O=Cc1cccc(-c2ccsc2)n1.[Na]>>O=C1NC(=O)/C(=C/c2ccnc(N3CCC(CNCc4cccc(-c5ccsc5)n4)CC3)n2)N1",
        "output": "775"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.C1CCOC1.CCCCCCCCOC1CCC(=O)N1.CCCC[N+](CCCC)(CCCC)CCCC.[Br-].[K+].[OH-]>>CCCCCCCCOC1CCC(=O)N1Cc1ccccc1",
        "output": "774"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)c1ccc(CN)cc1.CO.Cc1ccc(C(C)CC=O)o1.Cl.[BH4-].[Na+]>>Cc1ccc(C(C)CCNCc2ccc(C(C)(C)C)cc2)o1",
        "output": "627"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.Nc1ccc(Oc2cc(-n3cncn3)ncn2)cc1.O=C=Nc1ccc(Cl)c(C(F)(F)F)c1>>O=C(Nc1ccc(Oc2cc(-n3cncn3)ncn2)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1",
        "output": "912"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccccc1.O=C(Cl)CCCCCl.[Al+3].[Cl-].[Cl-].[Cl-].c1ccc2c(c1)CCO2>>O=C(CCCCCl)c1ccc2c(c1)CCO2",
        "output": "31"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1nc(C(C)(N)CC2CC2)no1.O=C(O)c1cc(OCCF)c(C2CC2)cn1>>Cc1nc(C(C)(CC2CC2)NC(=O)c2cc(OCCF)c(C3CC3)cn2)no1",
        "output": "137"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCOc1ccc2ccccc2c1CO.Cc1ccccc1.O.O=S(Cl)Cl.c1ccncc1>>C=CCOc1ccc2ccccc2c1CCl",
        "output": "81"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(CCCC#N)CC1.CO.N.[Ni]>>CC(C)(C)OC(=O)N1CCC(CCCCN)CC1",
        "output": "246"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCCCOc1ccnc2ccccc12>>CS(=O)(=O)OCCCOc1ccnc2ccccc12",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO.Cc1cc(-c2cccc(C#N)c2)c(C(=O)OCc2ccccc2)c(C)n1.[H][H].[Pd]>>Cc1cc(-c2cccc(C#N)c2)c(C(=O)O)c(C)n1",
        "output": "291"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CNC.CO.COc1ccc(N(C)c2nc(Cl)nc3ccc([N+](=O)[O-])cc23)cc1>>COc1ccc(N(C)c2nc(N(C)C)nc3ccc([N+](=O)[O-])cc23)cc1",
        "output": "36"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCNCC.COc1ccc(-c2cc(C(=O)O)nc3ccccc23)cc1.O=S(Cl)Cl>>CCN(CC)C(=O)c1cc(-c2ccc(OC)cc2)c2ccccc2n1",
        "output": "605"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCNCC3)c12.Cl.Cl.O=S(=O)(Cl)c1ccccc1>>COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(S(=O)(=O)c4ccccc4)CC3)c12",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[C@@H](N)C(F)(F)F.Cl.ClCCl.O=C(Cl)c1cc(F)c(Cl)cc1F.O=C([O-])O.[Na+]>>C[C@@H](NC(=O)c1cc(F)c(Cl)cc1F)C(F)(F)F",
        "output": "271"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.CCc1ccccc1NC(C)=O.O.O=C([O-])[O-].O=[N+]([O-])O.[Na+].[Na+]>>CCc1cccc([N+](=O)[O-])c1NC(C)=O",
        "output": "21"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CN(CC(=O)Nc1cccc(-c2cnc(NCCN3C(=O)NC(=O)C3(C)C)nc2-c2ccc(Cl)s2)c1)C(=O)OC(C)(C)C.Cl>>CNCC(=O)Nc1cccc(-c2cnc(NCCN3C(=O)NC(=O)C3(C)C)nc2-c2ccc(Cl)s2)c1",
        "output": "634"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.Cl.ClC1(Cl)CCC2(CC1)OCCO2.O>>O=C1CCC(Cl)(Cl)CC1",
        "output": "251"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)C(=O)Nc1ccccn1.CN(C)CCN(C)C.II.O.[Li]CCCC>>CC(C)(C)C(=O)Nc1ncccc1I",
        "output": "850"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COc1ccc(C(=O)c2cccc(S(=O)(=O)Cl)c2)cc1.ClCCl.N>>COc1ccc(C(=O)c2cccc(S(N)(=O)=O)c2)cc1",
        "output": "245"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OCCOCn1cpc2ncnc(N)c21.N>>Nc1ncnc2pcn(COCCO)c12",
        "output": "225"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.N#CC1(c2ccccc2)CCNCC1>>CC(C)(C)OC(=O)N1CCC(C#N)(c2ccccc2)CC1",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Cc1ccc(N)cc1-c1ccc(C(=O)NCC2CC2)cc1.Cc1oc(-c2ccccc2)cc1C(=O)O>>Cc1ccc(NC(=O)c2cc(-c3ccccc3)oc2C)cc1-c1ccc(C(=O)NCC2CC2)cc1",
        "output": "799"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.C[C@@H](N)C(=O)NCC(=O)OCc1ccccc1.C[C@H](NC(=O)CNC(=O)OC(C)(C)C)C(=O)NCC(=O)O.Cl.Cl.O.On1nnc2ccccc21>>C[C@H](NC(=O)CNC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](C)C(=O)NCC(=O)OCc1ccccc1",
        "output": "133"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)c1cc(C(F)(F)F)ccc1NS(=O)(=O)C(F)(F)F.Cl.O.[Li+].[OH-]>>O=C(O)c1cc(C(F)(F)F)ccc1NS(=O)(=O)C(F)(F)F",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CI.CN(C)C=O.CSc1nn2cc(-c3nc4ccc(O)cc4o3)nc2s1.O.[H-].[Na+]>>COc1ccc2nc(-c3cn4nc(SC)sc4n3)oc2c1",
        "output": "62"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CC(O)(CC)c1ccc(Cl)c(Cl)c1.C[Al](C)C.Cl.ClCCl.N>>CCC(O)(CC(N)=O)c1ccc(Cl)c(Cl)c1",
        "output": "163"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN=C=O.COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)C4CCN(C5CCNC5)C4)c3Cl)cccc2n1Cc1ccccn1.ClCCl>>CNC(=O)N1CCC(N2CCC(C(=O)NCC(=O)N(C)c3ccc(Cl)c(COc4cccc5c4nc(OC)n5Cc4ccccn4)c3Cl)C2)C1",
        "output": "437"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOP(=O)(COc1ccc(-c2c3ccccc3cc3sc4ccccc4c23)cc1)OCC.C[Si](C)(C)I.ClCCl>>O=P(O)(O)COc1ccc(-c2c3ccccc3cc3sc4ccccc4c23)cc1",
        "output": "535"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.COC(=O)c1cccc([N+](=O)[O-])c1SCc1ccccc1.O.[Fe]>>COC(=O)c1cccc(N)c1SCc1ccccc1",
        "output": "481"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CC[C@H](N)C1.CN1CCOCC1.Cc1ccccc1>>CC(=O)N[C@H]1CCN(C(=O)OC(C)(C)C)C1",
        "output": "339"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)[C@H]1CCCN(CC(O)(c2ccccc2)c2ccccn2)C1.O.[Na+].[OH-]>>O=C(O)[C@H]1CCCN(CC(O)(c2ccccc2)c2ccccn2)C1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1ccc(OCCc2ccncc2)cc1.C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.Cl[Pd]Cl.O.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc(OCCc3ccncc3)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Nc1cccc(S(=O)(=O)C(F)(F)F)c1.O=C(O)c1c(O)ccc2ccccc12>>O=C(Nc1cccc(S(=O)(=O)C(F)(F)F)c1)c1c(O)ccc2ccccc12",
        "output": "50"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2ccc([N+](=O)[O-])cc2OC(F)F)CC1.CO.[Pd]>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(N)cc2OC(F)F)CC1",
        "output": "202"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCC(NC(=O)OCc1ccccc1)P(=O)(OC)O[C@@H](CCCCNC(=O)C(F)(F)F)C(=O)N1CCC[C@H]1C(=O)OCC.CCOC(=O)[C@@H]1CCCN1.CO.[OH-].[OH-].[Pd+2]>>CCCCC(N)P(=O)(OC)O[C@@H](CCCCNC(=O)C(F)(F)F)C(=O)N1CCC[C@H]1C(=O)OCC",
        "output": "574"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.C[Si](C)(C)C(C(N)=O)[Si](C)(C)C.O=C(NN1CCNC1=O)c1cc(=O)c(OCc2ccccc2)c[nH]1>>O=C(NN1CCNC1=O)c1cc(=O)c(O)c[nH]1",
        "output": "264"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCN(S(C)(=O)=O)C(CO)C1.CI.CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1CO.ClCCl.[H-].[Na+]>>COCC1CN(C(=O)OC(C)(C)C)CCN1S(C)(=O)=O",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCOc2ccc(N)cc21.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2cc3n(c2c1)CCNC3=O>>CC(C)(C)OC(=O)N1CCOc2ccc(NC(=O)c3ccc4cc5n(c4c3)CCNC5=O)cc21",
        "output": "817"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COc1cccc(CCN)c1.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cc2sc(Cl)c(Cl)c2[nH]1.O=C([O-])[O-].[Ca+2]>>COc1cccc(CCNC(=O)c2cc3sc(Cl)c(Cl)c3[nH]2)c1",
        "output": "137"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)O)ccc3C)cc12.Cl.ClCCl.NC1(c2ncccn2)CC1.On1nnc2ccccc21>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5ncccn5)CC4)ccc3C)cc12",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1cc(C)ccc1-c1ccn(C)n1.Cc1ccc(-c2cnn(C)c2)c(C(=O)O)c1>>Cc1ccc(-c2ccn(C)n2)c(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCc1cc(-c2ccc(C(=O)O)s2)c(C)[nH]c1=O.NCc1ccccn1>>CCc1cc(-c2ccc(C(=O)NCc3ccccn3)s2)c(C)[nH]c1=O",
        "output": "736"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Brc1ccc(C2CCNC2)cc1.C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCO.CCOC(C)=O.ClC(Cl)Cl.[H-]>>CN1CCC(c2ccc(Br)cc2)C1",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cc(O[Si](C)(C)C(C)(C)C)ccc1F.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>CC(C)(C)[Si](C)(C)Oc1ccc(F)c(CBr)c1",
        "output": "29"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1nc(S(C)(=O)=O)ncc1-c1ccccc1.CO.ClCCl.O>>COc1ncc(-c2ccccc2)c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1",
        "output": "667"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CCc2c(-c3ccccc3)ccc3c(=O)c(C(=O)O)cn1c23.O=[N+]([O-])O>>CC1CCc2c(-c3ccc([N+](=O)[O-])cc3)ccc3c(=O)c(C(=O)O)cn1c23",
        "output": "21"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCN(c2cc(C(=O)O)cc(C(F)(F)F)c2)CC1.Cc1ccc(N)cc1Nc1ncccc1-c1cc(NC2CC2)ncn1.F[P-](F)(F)(F)(F)F>>Cc1ccc(NC(=O)c2cc(N3CCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1ncccc1-c1cc(NC2CC2)ncn1",
        "output": "50"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.C1COCCO1.CCOC(=O)Cc1ccc(C=C2CCCC2=O)cc1>>O=C(O)Cc1ccc(C=C2CCCC2=O)cc1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CN1CCOCC1.Cl.F[P-](F)(F)(F)(F)F.N[C@H]1CCOC1.O=C(O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1>>O=C(N[C@H]1CCOC1)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.C[O-].Cc1c(F)cnc(Cl)c1Br.O.[Na+]>>COc1ncc(F)c(C)c1Br",
        "output": "433"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.CO[C@H](c1ccc(N2CCC3(CCC(=O)CC3)C2=O)cc1)C(F)(F)F.[BH4-].[Na+]>>CO[C@H](c1ccc(N2CCC3(CCC(O)CC3)C2=O)cc1)C(F)(F)F",
        "output": "91"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "NC(=O)c1cc(-c2cccnc2[C@@H](N)Cc2cc(F)cc(F)c2)ccc1F.O=C(O)C(F)(F)F.O=C(O)Cn1nc(C(F)(F)F)c2c1C1CC1CC2>>NC(=O)c1cc(-c2cccnc2[C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)(F)F)c3c2C2CC2CC3)ccc1F",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1cc(NC(=O)c2ccccc2Cl)n(C(=O)OC(C)(C)C)n1.Cl>>COC(=O)c1cc(NC(=O)c2ccccc2Cl)[nH]n1",
        "output": "896"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CO.COC(=O)c1cc(C(C)=O)ccc1OC.COC(OC)N(C)C>>COC(=O)c1cc(C(=O)/C=C/N(C)C)ccc1OC",
        "output": "898"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(=O)Cl.Cc1cc(Br)cc(F)c1N.Cl.O.c1ccncc1>>Cc1cc(Br)cc(F)c1NC(=O)C(C)(C)C",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.CCC1(C)Cc2c(C)c(C)c(C=O)c(C)c2C1.Cl.O.[Na+].[OH-]>>CCC1(C)Cc2c(C)c(C)c(C=CC(C)=O)c(C)c2C1",
        "output": "295"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCC1CCCO1.CCCn1c(COCC)nc2c(N)nc3ccc(O)cc3c21.CN(C)C=O.O.O=C([O-])[O-].[Cl-].[Cs+].[Cs+].[Na+]>>CCCn1c(COCC)nc2c(N)nc3ccc(OCC4CCCO4)cc3c21",
        "output": "18"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "N[C@H]1CCN(CCc2ccc(F)cc2)C1.O=C(O)C1C2CCC1CC2>>O=C(N[C@H]1CCN(CCc2ccc(F)cc2)C1)C1C2CCC1CC2",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(C=O)c(Br)c1.O=S(=O)(O)O.O=[N+]([O-])O>>Cc1cc(Br)c(C=O)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)O[Al](OC(C)(C)C)OC(C)(C)C.CCOCC.COC(=O)NC(C(=O)NN(CC(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1)Cc1ccc(-c2ccccn2)cc1)C(C)(C)C.[H-].[Li+]>>COC(=O)NC(C(=O)NN(Cc1ccc(-c2ccccn2)cc1)CC(O)C(Cc1ccccc1)NC(=O)OCc1ccccc1)C(C)(C)C",
        "output": "91"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC2=NCCCN2CC1.CCOC(=O)C1CCN(CCN)CC1.CS(C)=O.Cc1cc([N+](=O)[O-])c(Cl)cc1Cl>>CCOC(=O)C1CCN(CCNc2cc(Cl)c(C)cc2[N+](=O)[O-])CC1",
        "output": "304"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)Nc1noc2ccc(CN3C(=O)c4ccccc4C3=O)cc12.CCCCO.CCOC(C)=O.ClCCl.NN.O>>CC(C)(C)OC(=O)Nc1noc2ccc(CN)cc12",
        "output": "418"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)c1cnc(Cl)c([N+](=O)[O-])c1NC1CCCN(C(=O)OC(C)(C)C)CC1.CO.N>>CCOC(=O)c1cnc(N)c([N+](=O)[O-])c1NC1CCCN(C(=O)OC(C)(C)C)CC1",
        "output": "388"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CI.CN(C)C=O.COCCCN1CCOc2ccc(CO[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)[C@@H](CCNC(C)=O)C[C@@H]3c3ccc(OC)cc3)cc21.Cl.[H-].[Na+]>>COCCCN1CCOc2ccc(CO[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)[C@@H](CCN(C)C(C)=O)C[C@@H]3c3ccc(OC)cc3)cc21",
        "output": "83"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COc1cnc(-c2nn(Cc3c(Cl)ccc([N+](=O)[O-])c3Cl)c3ccccc23)nc1Nc1ccncc1.NN.[Ni]>>COc1cnc(-c2nn(Cc3c(Cl)ccc(N)c3Cl)c3ccccc23)nc1Nc1ccncc1",
        "output": "71"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCNCC.Cc1oc(-c2ccc(Br)cc2)nc1CCOS(C)(=O)=O>>CCN(CC)CCc1nc(-c2ccc(Br)cc2)oc1C",
        "output": "496"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.ClCCl.Nc1nc(-c2ccc(Cl)cc2)cs1.O=C(Cl)C(=O)Cl.O=C(O)Cc1ccc2c(c1)OCO2.c1ccncc1>>O=C(Cc1ccc2c(c1)OCO2)Nc1nc(-c2ccc(Cl)cc2)cs1",
        "output": "681"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)Nc1ccc(F)cc1CN1CCC(COc2cc(F)c(C(=O)O)cc2C2CC2)CC1.CS(N)(=O)=O.NS(=O)(=O)C1CC1.O=C(O)c1cc(C2CC2)c(OCC2(F)CCN(Cc3cc(C(F)(F)F)cc(Cl)c3F)CC2)cc1F>>CC(C)Nc1ccc(F)cc1CN1CCC(COc2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc2C2CC2)CC1",
        "output": "580"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(Cc2cn(C)c3ccc(NC(=O)OC4CCCC4)cc23)c(OC)c1.O.O.[Li+].[OH-]>>COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=C(Nc1cccc(F)c1)c1cc2cc(C3CCN(Cc4ccccc4)C3)ccc2[nH]1.[Pd]>>O=C(Nc1cccc(F)c1)c1cc2cc(C3CCNC3)ccc2[nH]1",
        "output": "84"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)c1ncn(-c2ccc(C#N)cc2F)n1.[Na+].[OH-]>>N#Cc1ccc(-n2cnc(C(=O)O)n2)c(F)c1",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COc1cc(N)c(Cl)cc1Cl.N#Cc1cnc2c(Br)csc2c1Br.N#Cc1cnc2c(Br)csc2c1Cl.[Cl-].[H-].[Na+].[Na+]>>COc1cc(Nc2c(C#N)cnc3c(Br)csc23)c(Cl)cc1Cl",
        "output": "927"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCOC(CCCN)OCC.CN(C)c1cccc2c(S(=O)(=O)Cl)cccc12.ClCCl>>CCOC(CCCNS(=O)(=O)c1cccc2c(N(C)C)cccc12)OCC",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)[C@@H](NC(=O)c1cc2ccccc2cc1N)C1CCCCC1.Cl.O=C=Nc1c(Cl)cc(F)cc1Cl.c1ccncc1>>COC(=O)[C@@H](NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(Cl)cc(F)cc1Cl)C1CCCCC1",
        "output": "993"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CO.O=S(Cl)Cl>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CCl",
        "output": "477"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=Cc1ccc2c(c1)cc(-c1ccccc1)n2S(=O)(=O)c1ccccc1.[BH4-].[Cl-].[NH4+].[Na+]>>O=S(=O)(c1ccccc1)n1c(-c2ccccc2)cc2cc(CO)ccc21",
        "output": "356"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O.CCN=C=NCCCN(C)C.CN.CN(C)C=O.CN1CCOCC1.Cl.Cl.O.O.On1nnc2ccccc21.On1nnc2ccccc21>>CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.COC(=O)Cc1ccccc1O.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.OCCCc1cn(-c2ccc(C(F)(F)F)cn2)nc1C1CCCCC1>>O=C(O)Cc1ccccc1OCCCc1cn(-c2ccc(C(F)(F)F)cn2)nc1C1CCCCC1",
        "output": "928"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.CCOC(C)=O.C[C@H](N)c1nc2ccc(F)cc2n1-c1cc(F)cc(F)c1.N#Cc1c(N)ncnc1Cl>>C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2n1-c1cc(F)cc(F)c1",
        "output": "110"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CN(C)c1ccncc1.ClCCl.N#Cc1cnc(N)cc1C(F)(F)F.O=C(Cl)c1ccc(Br)cc1>>N#Cc1cnc(NC(=O)c2ccc(Br)cc2)cc1C(F)(F)F",
        "output": "463"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)O[C@@H](c1ccccc1-c1ccc(Cl)cc1)C1CCN(c2ccc(C(=O)O)cc2)CC1.NS(=O)(=O)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c([N+](=O)[O-])c1>>CC(C)(C)[Si](C)(C)O[C@@H](c1ccccc1-c1ccc(Cl)cc1)C1CCN(c2ccc(C(=O)NS(=O)(=O)c3ccc(N[C@H](CCN4CCOCC4)CSc4ccccc4)c([N+](=O)[O-])c3)cc2)CC1",
        "output": "579"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.N#Cc1ccc(F)c([N+](=O)[O-])c1.NCCCO>>N#Cc1ccc(NCCCO)c([N+](=O)[O-])c1",
        "output": "572"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrBr.CC(=O)O.Cc1cc(NCC(C)O)c2ccccc2n1>>Cc1nc2ccccc2c(NCC(C)O)c1Br",
        "output": "292"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C(=O)OC(C)(C)C)C1CN(Cc2ccccc2)CC1c1ccccc1.CO.O=C[O-].[NH4+].[Pd]>>CN(C(=O)OC(C)(C)C)C1CNCC1c1ccccc1",
        "output": "84"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCC1CC1.CS(C)=O.O=C([O-])[O-].O=c1cc(Cl)[nH]c(=O)[nH]1.[K+].[K+].[Na+].[OH-]>>O=c1cc(Cl)n(CC2CC2)c(=O)[nH]1",
        "output": "327"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.C[C@H](N)C#N.F[P-](F)(F)(F)(F)F.O=C(O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1>>C[C@@H](C#N)NC(=O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.Cc1nc(C(=O)O)c(C(=O)NCCc2nc3ccccc3n2C)n1C>>Cc1nc(C(=O)N2CCOCC2)c(C(=O)NCCc2nc3ccccc3n2C)n1C",
        "output": "729"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)C(=O)Cl.CCN(CC)CC.COc1ccccc1N.ClCCl.O>>COc1ccccc1NC(=O)C(C)(C)C",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.N#Cc1cccc(C(=O)O)c1.NO>>N=C(NO)c1cccc(C(=O)O)c1",
        "output": "854"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CO.CSc1nn2cc(-c3nc4ccc(O)cc4o3)nc2s1.Cl.ClCc1ccccn1.O.O=C([O-])[O-].[Cs+].[Cs+]>>CSc1nn2cc(-c3nc4ccc(OCc5ccccn5)cc4o3)nc2s1",
        "output": "616"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(O)(c1ccccc1)c1ccc(Cl)c(N)c1.CCC(O)(c1ccccc1)c1ccccc1N.CO.[K+].[OH-]>>CCC(O)(c1ccccc1)c1cccc(N)c1",
        "output": "253"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1CC(=O)NN=C1c1ccc(N2CCNCC2)c([N+](=O)[O-])c1.CCN(CC)CC.COc1ccc(C(=O)Cl)cc1.ClCCCl.O>>COc1ccc(C(=O)N2CCN(c3ccc(C4=NNC(=O)CC4C)cc3[N+](=O)[O-])CC2)cc1",
        "output": "201"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCCC1=O.Cl.F[P-](F)(F)(F)(F)F.NC1CCC(n2c(=O)c3cc(F)cnc3n(C3CCCC3)c2=O)CC1.O=C(O)c1cn2ccccc2n1.On1nnc2cccnc21>>O=C(NC1CCC(n2c(=O)c3cc(F)cnc3n(C3CCCC3)c2=O)CC1)c1cn2ccccc2n1",
        "output": "697"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.ClCCl.N#C[C@@H]1C[C@@]2(c3ccccc3)[C@H](O)CC[C@@H]1N2Cc1ccccc1.O=C(Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>N#C[C@@H]1C[C@@]2(c3ccccc3)[C@H](OC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC[C@@H]1N2Cc1ccccc1",
        "output": "51"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "O=C(O)c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1.c1cncc(C2CCCN2)c1>>O=C(c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1)N1CCCC1c1cccnc1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccc2c(c1)OCCn1cc(-c3ncnn3CCO)nc1-2.COC(OC)N(C)C>>CN(C)/C=C/C(=O)c1ccc2c(c1)OCCn1cc(-c3ncnn3CCO)nc1-2",
        "output": "898"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OCCCNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CN[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCCCOC(C)=O",
        "output": "634"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCCBr.C=C(C)n1c(=O)[nH]c2ccccc21.CN(C)C=O.[H-].[Na+]>>C=C(C)n1c(=O)n(CCBr)c2ccccc21",
        "output": "495"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C(=O)OC(C)(C)C)C(COCc1ccccc1)COCC1COC(C)(C)O1.CO.[H][H].[Pd]>>CN(C(=O)OC(C)(C)C)C(CO)COCC1COC(C)(C)O1",
        "output": "178"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCN[C@@H](Cn2ccnc2)C1.CO.COC[C@]1(O)CCCC[C@H]1n1cnc(C(=O)N2CCNC[C@H]2CCOc2ccccc2C(C)=O)c1-c1ccccc1.O=C([O-])O.[BH4-].[Na+].[Na+]>>COC[C@]1(O)CCCC[C@H]1n1cnc(C(=O)N2CCNC[C@H]2CCOc2ccccc2C(C)O)c1-c1ccccc1",
        "output": "24"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)Cc2c(C(=O)O)ccc(Cl)c2NC1c1cccc(N2CCOCC2)c1.CN(C)C=O.NS(=O)(=O)C1CC1.O=C(n1ccnc1)n1ccnc1.[H-].[Na+]>>CC1(C)Cc2c(C(=O)NS(=O)(=O)C3CC3)ccc(Cl)c2NC1c1cccc(N2CCOCC2)c1",
        "output": "580"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.O=C(C1CNC1)N1CCCN(C2CCC2)CC1.O=C(Cl)CCl.O=C([O-])[O-].[Na+].[Na+]>>O=C(CCl)N1CC(C(=O)N2CCCN(C3CCC3)CC2)C1",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1cc(COCC2(c3ccccc3)CCNCC2)c2ccccc2n1.ClCCl.[Na+]>>Cc1cc(COCC2(c3ccccc3)CCN(C)CC2)c2ccccc2n1",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC[Sn](CCCC)(CCCC)O[Sn](CCCC)(CCCC)CCCC.COC(=O)c1ccc2c(cnn2S(=O)(=O)c2ccc(C)cc2)c1Nc1ccc(I)cc1F.Cc1ccccc1>>Cc1ccc(S(=O)(=O)n2ncc3c(Nc4ccc(I)cc4F)c(C(=O)O)ccc32)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)c1cc2cc(Cl)cc(Cc3ccc(C(=O)O)o3)c2o1.CCN=C=NCCCN(C)C.CCOCC.CN(C)C=O.Nc1ccc(CO)cc1.O.Oc1cccc2[nH]nnc12>>CC(C)c1cc2cc(Cl)cc(Cc3ccc(C(=O)Nc4ccc(CO)cc4)o3)c2o1",
        "output": "860"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1C(=O)COc2cc(C3(O)C(=O)N(C(c4ccccc4)c4ccccc4)c4ccccc43)c(O)cc21.O=C1N(Cc2ccc(C(F)(F)F)o2)c2ccccc2C1(O)c1cc(Br)ccc1O>>O=C1C(c2cc(Br)ccc2O)c2ccccc2N1Cc1ccc(C(F)(F)F)o1",
        "output": "964"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1[nH]c(=O)[nH]c1C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>Cc1[nH]c(=O)[nH]c1C(=O)O",
        "output": "569"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)C1=Cc2cc(Cl)c(CBr)cc2OC1C(F)(F)F.CN(C)C=O.CNC(C)C.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C1=Cc2cc(Cl)c(CN(C)C(C)C)cc2OC1C(F)(F)F",
        "output": "248"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.COCc1cnc(Cl)nc1.CS(=O)(=O)c1c(F)cc(COC[C@@H]2C[C@@H]2C2CCNCC2)cc1F.CS(C)=O.Cl.O=C([O-])[O-].[Cs+].[Cs+]>>COCc1cnc(N2CCC([C@H]3C[C@H]3COCc3cc(F)c(S(C)(=O)=O)c(F)c3)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N(C)C.CC(C)(C)[O-].CN1CCCC1CCCl.COCOc1cccc(CCc2ccccc2O)c1.Cl.[K+]>>COCOc1cccc(CCc2ccccc2OCCC2CCCN2C)c1",
        "output": "74"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COCCN(CCOC)c1ccccc1N.O.S=C(Cl)Cl>>COCCN(CCOC)c1ccccc1N=C=S",
        "output": "114"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1=COCCC1.CCCCCCCCCCC[C@H](CC(=O)N[C@@H](CO)CCCNC(=O)OCc1ccccc1)OCc1ccccc1.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.c1cc[nH+]cc1>>CCCCCCCCCCC[C@H](CC(=O)N[C@H](CCCNC(=O)OCc1ccccc1)COC1CCCCO1)OCc1ccccc1",
        "output": "306"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=c1cc(COC2CCCCO2)occ1OCCCCBr.[H-].[Na+].c1ccc2[nH]ccc2c1>>O=c1cc(COC2CCCCO2)occ1OCCCCn1ccc2ccccc21",
        "output": "470"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNCCC#Cc1cccc(CF)n1.O=S(=O)(Cl)c1ccccc1Cl>>CN(CCC#Cc1cccc(CF)n1)S(=O)(=O)c1ccccc1Cl",
        "output": "99"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(N)sc4n3)c2)n(C)n1.O.O=C(Cl)C1CC1>>Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4n3)c2)n(C)n1",
        "output": "553"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CCCC(C)(C)CO.CC(=O)NCCCS(=O)(=O)Cl.CCN(CC)CC.CN(C)c1ccncc1.ClCCl>>C=CCCC(C)(C)COS(=O)(=O)CCCNC(C)=O",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC#N.Cc1ccc(S(=O)(=O)O)cc1.N#CCC1(n2cc(-c3ccnc(Cl)n3)cn2)CCN(C(=O)c2ccno2)CC1.Nc1ccc(-n2cccn2)cc1.O>>N#CCC1(n2cc(-c3ccnc(Nc4ccc(-n5cccn5)cc4)n3)cn2)CCN(C(=O)c2ccno2)CC1",
        "output": "808"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)c1ccc(CN2CCC(CO)CC2)cc1.CCN(CC)CC.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)c1ccc(CN2CCC(C=O)CC2)cc1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)N.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc2ccc(C(=O)O)c(C3CC3)c2n1.F[P-](F)(F)(F)(F)F>>Cc1ccc2ccc(C(=O)NC(C)(C)C)c(C3CC3)c2n1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)Nc1nc2ccc(C(=O)NCCOC(C)C)cc2n2c(=O)[nH]nc12.CCOCC.Cl.ClCCl.FB(F)F.[BH4-].[Na+].[Na+].[OH-]>>CC(C)Nc1nc2ccc(CNCCOC(C)C)cc2n2c(=O)[nH]nc12",
        "output": "215"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCC=CCCCCCCCC.CCOCC.O.OO.[Cl-].[Na+].[Na+].[OH-]>>CCCCCCCCCCCC",
        "output": "143"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)OC(=O)Nc2ccc(OCCCCCl)cc21.COc1cccc(S)c1>>COc1cccc(SCCCCOc2ccc3c(c2)C(C)(C)OC(=O)N3)c1",
        "output": "460"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCCCCCCC(=O)N(C)Cc1cc(-c2ccccc2)cc(-c2ccc(C=C3SC(=O)NC3=O)cc2)c1.[H][H]>>CCCCCCCC(=O)N(C)Cc1cc(-c2ccccc2)cc(-c2ccc(CC3SC(=O)NC3=O)cc2)c1",
        "output": "762"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCN(CC)CC.CNC.Cl.ClC(Cl)Cl.Oc1cccc(-c2nc(-c3ccnc(F)c3)c3sccc3n2)c1>>CN(C)c1cc(-c2nc(-c3cccc(O)c3)nc3ccsc23)ccn1",
        "output": "756"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.CCOC(C)=O.C[C@H]1CNC[C@H](C)N1S(=O)(=O)c1ccc(C(C)(C)C)cc1.Clc1cccnc1Cl>>C[C@H]1CN(c2ncccc2Cl)C[C@H](C)N1S(=O)(=O)c1ccc(C(C)(C)C)cc1",
        "output": "220"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=O.C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1.ClCCl>>C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1C",
        "output": "217"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cccc(C2Oc3cccc(OC)c3-c3ccc(CS(N)(=O)=O)cc32)c1.CCOC(C)=O.Cl.[Li+].[OH-]>>COc1cccc2c1-c1ccc(CS(N)(=O)=O)cc1C(c1cccc(C(=O)O)c1)O2",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OCc4ccccc4)cc3)oc2c1.CO.[H][H].[Pd]>>CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(O)cc3)oc2c1",
        "output": "23"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.CCOC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)OC(C)(C)C.CCOC(C)=O>>CCOC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)OC(C)(C)C",
        "output": "6"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "N=C(NN)c1ncccc1Br.O=Cc1cccc([N+](=O)[O-])c1>>O=[N+]([O-])c1cccc(-c2nc(-c3ncccc3Br)n[nH]2)c1",
        "output": "994"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCOC(=O)C(C)OP(=O)(CCNC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)Oc1ccccc1.CN(C)C=O.O.[Na+].[OH-]>>CC(OP(=O)(CCNC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)Oc1ccccc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN[C@@H]1CC[C@@H](O)CC1.ClCCl.c1c[nH]cn1>>CN[C@@H]1CC[C@@H](O[Si](C)(C)C(C)(C)C)CC1",
        "output": "193"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(COc2nc(SC)ncc2C(=O)NCc2ccc(F)cc2)cc1Cl.ClCCl.O=C(OO)c1cccc(Cl)c1>>COc1ccc(COc2nc(S(C)=O)ncc2C(=O)NCc2ccc(F)cc2)cc1Cl",
        "output": "595"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCl.Nc1cc(F)cc(F)c1C(=O)O.O=C(Cl)Cc1ccc2c(c1)OCO2.c1ccncc1>>O=C(Cc1ccc2c(c1)OCO2)Nc1cc(F)cc(F)c1C(=O)O",
        "output": "9"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrBr.CCc1ncsc1CSc1nc(O)cc(C(F)(F)F)n1.ClC(Cl)(Cl)Cl.ClCCl.ClCCl.O.O=S([O-])([O-])=S.[Na+].[Na+]>>CCc1ncsc1CSc1nc(O)c(Br)c(C(F)(F)F)n1",
        "output": "381"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1ncc(Br)cc1C(=O)Nc1ccncc1.O=C(O)CCc1ccc(B(O)O)cc1>>Nc1ncc(-c2ccc(CCC(=O)O)cc2)cc1C(=O)Nc1ccncc1",
        "output": "833"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.N#CCC(O)c1cccc(N)c1.O=CCc1ccccc1.[BH4-].[Na+]>>N#CCC(O)c1cccc(NCCc2ccccc2)c1",
        "output": "336"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C[C@H](N)C(=O)N[C@H](C=O)CC(=NNC(N)=O)OC(C)(C)C.CCN=C=NC(N)CC(C)C.CN1CCCC1=O.Cl.ClCCl.O.O=C(O)COc1cccc2ccccc12.Oc1cccc2[nH]nnc12>>CC(C)C[C@H](NC(=O)COc1cccc2ccccc12)C(=O)N[C@H](C=O)CC(=NNC(N)=O)OC(C)(C)C",
        "output": "133"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCC[n+]1ccn(C)c1.CCOCC.Cc1cnc2c(C)nn(Cc3ccccc3)c2n1.F[B-](F)(F)F.O=C1CCC(=O)N1Br>>Cc1nc2c(nc1Br)c(C)nn2Cc1ccccc1",
        "output": "665"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.ClCCl.O=C(OCc1ccccc1)N1CCC([C@H]2C[C@H]2CCO)CC1.Oc1cc(F)c(Br)cc1F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(OCc1ccccc1)N1CCC([C@H]2C[C@H]2CCOc2cc(F)c(Br)cc2F)CC1",
        "output": "478"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CC#N.CCOC(C)=O.CCc1cc(C=O)cc(C)c1O.O.O=C([O-])[O-].[K+].[K+]>>CCc1cc(C=O)cc(C)c1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[C@@H]1C[C@H]1c1ccccc1Cl.CO.CON.Cl.O.c1ccncc1>>CON=C(C)[C@@H]1C[C@H]1c1ccccc1Cl",
        "output": "86"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=[N+]([O-])c1cc2c(cnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1CCNCc1ccc(F)cc1.[Zn]>>Nc1cc2c(cnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1CCNCc1ccc(F)cc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNCCc1ccccn1.F[P-](F)(F)(F)(F)F.Nc1ccc(C(=O)O)cc1>>CN(CCc1ccccn1)C(=O)c1ccc(N)cc1",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)CC(C)N1CCc2ccc([N+](=O)[O-])cc2C1.Cl[Sn](Cl)(Cl)Cl.O.O.O=C([O-])O.[Na+]>>CCOC(=O)CC(C)N1CCc2ccc(N)cc2C1",
        "output": "71"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOP(=O)(CNc1ccc(Cl)cc1[N+](=O)[O-])OCC.[H][H].[Pt]>>CCOP(=O)(CNc1ccc(Cl)cc1N)OCC",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(O)(CN)C1CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O=C(O)c1cc(Br)c(OCC(F)(F)F)nc1C(F)(F)F>>CC(O)(CNC(=O)c1cc(Br)c(OCC(F)(F)F)nc1C(F)(F)F)C1CC1",
        "output": "674"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCCC1=O.COc1cc2c(Cl)ncnc2cc1OCc1ccccc1.Cc1cc2c(F)c(O)ccc2[nH]1.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCc1ccccc1",
        "output": "668"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.COCCl.Cc1cc(O)cc(C)c1-c1cccc(C=O)c1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>COCOc1cc(C)c(-c2cccc(C=O)c2)c(C)c1",
        "output": "375"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COCCn1c(-c2ccc(C(C)C)cc2)nc2c(Br)c(C=O)cc(OC)c21.[BH4-].[Na+]>>COCCn1c(-c2ccc(C(C)C)cc2)nc2c(Br)c(CO)cc(OC)c21",
        "output": "356"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.O=C(O)Cc1cc([N+](=O)[O-])ccc1F>>O=[N+]([O-])c1ccc(F)c(CCO)c1",
        "output": "231"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCI.Nc1nc(-c2ccco2)c(-c2ccc(=O)[nH]c2)c(-c2ccco2)n1>>CCn1cc(-c2c(-c3ccco3)nc(N)nc2-c2ccco2)ccc1=O",
        "output": "302"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCBr.CCCN(CCC)C1Cc2cc(O)c(OS(=O)(=O)C(F)(F)F)cc2C1>>CCCN(CCC)C1Cc2cc(OCC)c(OS(=O)(=O)C(F)(F)F)cc2C1",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "NCCCN1CCC(c2cccc(NC(=O)C3CC3)c2)CC1.O=C(O)C1(c2ccc(Cl)cc2)CC1>>O=C(Nc1cccc(C2CCN(CCCNC(=O)C3(c4ccc(Cl)cc4)CC3)CC2)c1)C1CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(Oc1nc2ccc(Cl)cc2c(-c2cccc(Cl)c2)c1C(=O)OC(C)(C)C)C(F)(F)F.Cl>>CC(Oc1nc2ccc(Cl)cc2c(-c2cccc(Cl)c2)c1C(=O)O)C(F)(F)F",
        "output": "569"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.Cl.ClCc1ccccc1.O=C([O-])O.O=Cc1ccc(O)cc1O.[I-].[K+].[Na+]>>O=Cc1ccc(OCc2ccccc2)cc1O",
        "output": "49"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(CCCCCl)c1ccc(C(F)(F)F)cc1.O=C(Nc1cccc(C2CCNCC2)c1)C1CC1>>O=C(CCCCN1CCC(c2cccc(NC(=O)C3CC3)c2)CC1)c1ccc(C(F)(F)F)cc1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCCCCCCC(=O)O.ClC(Cl)Cl.O.Oc1cccc(O)c1.[Ca+2].[Cl-].[Cl-].[Cl-].[Cl-].[Zn+2]>>CCCCCCCCCCCC(=O)c1ccc(O)cc1O",
        "output": "435"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrC(Br)(Br)Br.CN(C)C=O.Cc1cc(-c2nc3cc(F)cc(F)c3c(=O)[nH]2)cc(C)c1OCCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(-c2nc3cc(F)cc(F)c3c(=O)[nH]2)cc(C)c1OCCBr",
        "output": "378"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCc2nc(Nc3ccccc3)ncc2C1.CC(C)=O.CC(C)O.Cl>>c1ccc(Nc2ncc3c(n2)CCNC3)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCc1nc(OC)c(NC(=O)N2CCN(c3cccc(F)c3)CC2)cc1C(=O)O.Nc1cc(CO)cc(Nc2c3ccccc3nc3ccccc23)c1>>CCc1nc(OC)c(NC(=O)N2CCN(c3cccc(F)c3)CC2)cc1C(=O)Nc1cc(CO)cc(Nc2c3ccccc3nc3ccccc23)c1",
        "output": "739"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)c1cnn(-c2c(Cl)cc(Cl)cc2Cl)c1C.O.[Na+].[OH-]>>Cc1c(C(=O)O)cnn1-c1c(Cl)cc(Cl)cc1Cl",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNC1.C1COCCO1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CCN(CC)CC.O=C([O-])[O-].OCc1cncc(Br)c1.[Cs+].[Cs+]>>OCc1cncc(N2CCCC2)c1",
        "output": "597"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrC1CCOCC1.CS(=O)(=O)OC1CCOCC1.Cc1cc(O)cc(C)c1Br.Cc1ccc(S(=O)(=O)OC2CCOCC2)cc1.ClC1CCOCC1.IC1CCOCC1.OC1=CCOC=C1>>Cc1cc(OC2CCOCC2)cc(C)c1Br",
        "output": "318"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1COc1cncc(N2CCC(CCOc3ccc(OCc4ccccc4)cc3)CC2)c1.CO.ClCCl.[Pd]>>CC(C)(C)OC(=O)N1CCC[C@H]1COc1cncc(N2CCC(CCOc3ccc(O)cc3)CC2)c1",
        "output": "23"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COc1ccc(CC(O)COS(=O)(=O)c2ccc(C)cc2)c(OCc2ccccc2)c1.[Pd]>>COc1ccc(CC(O)COS(=O)(=O)c2ccc(C)cc2)c(O)c1",
        "output": "23"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NC(C)(C)C(=O)Nc1nc(-c2ccccc2)c(Cc2ccccc2)s1.CCOC(C)=O.Cl>>CC(C)(N)C(=O)Nc1nc(-c2ccccc2)c(Cc2ccccc2)s1",
        "output": "431"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NC1C2CC3CC1CC(O)(C3)C2.O=C(O)c1cccc(OCCC2CCN(S(=O)(=O)C3CC3)CC2)c1>>O=C(NC1C2CC3CC1CC(O)(C3)C2)c1cccc(OCCC2CCN(S(=O)(=O)C3CC3)CC2)c1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COc1ccnc(-c2cccc([N+](=O)[O-])c2)c1.[Pd]>>COc1ccnc(-c2cccc(N)c2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CC(C)(C)OC(=O)N1CC=C(c2ccn3nccc3n2)CC1.CO>>C1=C(c2ccn3nccc3n2)CCNC1",
        "output": "800"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.II.O.O=C([O-])[O-].O=Cc1ccc2cn[nH]c2c1.O=S([O-])S(=O)[O-].[K+].[K+].[Na+].[Na+]>>O=Cc1ccc2c(I)n[nH]c2c1",
        "output": "923"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)OC(C)C.CCOC(C)=O.CN1CCNCC1.COc1ccc(Nc2nc(N[C@@H]3CC[C@@H](O)CC3)c(Cl)nc2C(N)=O)cc1N1CCC(=O)CC1.ClCCCl.O=C([O-])O.[Na+].[Na+]>>COc1ccc(Nc2nc(N[C@@H]3CC[C@@H](O)CC3)c(Cl)nc2C(N)=O)cc1N1CCC(N2CCN(C)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CNC(=O)c1ccc(Oc2cc3c(cc2I)CCNCC3)nc1.CO.O=C1CCC1>>CNC(=O)c1ccc(Oc2cc3c(cc2I)CCN(C2CCC2)CC3)nc1",
        "output": "187"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CO.COC(=O)c1c(O)cc(C=O)cc1F.Cl.[Na+].[OH-]>>O=Cc1cc(O)c(C(=O)O)c(F)c1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CN(C)CCNc1ccc([N+](=O)[O-])cn1.Cl.O.[Cl-].[Fe].[NH4+]>>CN(C)CCNc1ccc(N)cn1",
        "output": "269"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)Nc1cc(CCc2cccc(N)c2)ccn1.CN(C)C=O.Fc1cnc(Cl)nc1Cl.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)Nc1cc(CCc2cccc(Nc3nc(Cl)ncc3F)c2)ccn1",
        "output": "352"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.N#CC1(c2ccsc2)CCCCC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCC1(c2ccsc2)CCCCC1",
        "output": "246"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CN1CC2CN(C(=O)OC(C)(C)C)CCc3c(Cl)cc(Cl)c1c32.Cl.O=C([O-])O.[Na+]>>CN1CC2CNCCc3c(Cl)cc(Cl)c1c32",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.CC(C)(C)c1cc(CC(NC(=O)OCc2ccccc2)c2nccs2)ccc1O.CSc1ccccc1.ClCCl.O.[Na+].[OH-]>>CC(C)(C)c1cc(CC(N)c2nccs2)ccc1O",
        "output": "574"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COc1ccc(-c2nn(COCC[Si](C)(C)C)c3c2Cc2sc(-c4ccncc4)cc2-3)cc1.Cl>>COc1ccc(-c2n[nH]c3c2Cc2sc(-c4ccncc4)cc2-3)cc1",
        "output": "813"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(CC2CN(Cc3ccccc3)CC2O)n1.CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)Nc1cccc(CC2CN(Cc3ccccc3)CC2=O)n1",
        "output": "650"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](N)C1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)C1CC1>>CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)C2CC2)C1",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cl.Cn1c(=O)n(CCOC2CCCCO2)c(=O)c2c1nc(OCCOc1cccc(OC(F)(F)F)c1)n2Cc1ccc(Cl)cc1.O=C([O-])O.[Na+]>>Cn1c(=O)n(CCO)c(=O)c2c1nc(OCCOc1cccc(OC(F)(F)F)c1)n2Cc1ccc(Cl)cc1",
        "output": "543"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)OB(c2cnc3[nH]ccc3c2)OC1(C)C.NC(=O)c1ccc(Br)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)F)c3c2C(F)(F)CCC3(F)F)n1>>NC(=O)c1ccc(-c2cnc3[nH]ccc3c2)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)F)c3c2C(F)(F)CCC3(F)F)n1",
        "output": "967"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(c2csc(Cn3ccc([N+](=O)[O-])n3)n2)OCCO1.CCO.N#N.O.[Cl-].[Fe].[NH4+]>>CC1(c2csc(Cn3ccc(N)n3)n2)OCCO1",
        "output": "684"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COCC[C@H]1CN(C2=Nc3ccccc3Nc3ccc(C)cc32)CCN1.ClCCCl.[Na+]>>COCC[C@H]1CN(C2=Nc3ccccc3Nc3ccc(C)cc32)CCN1C",
        "output": "217"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C(=O)Nc1cncc(C2CCN(CCCN)CC2)c1.O=C(O)C(O)(c1ccccc1)c1ccccc1>>CC(C)C(=O)Nc1cncc(C2CCN(CCCNC(=O)C(O)(c3ccccc3)c3ccccc3)CC2)c1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)COC(=O)Cl.CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O.CSCC[C@@H](N)C(N)=O>>CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)C(N)=O",
        "output": "133"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)Cc1cncc(-c2ccc(F)cc2CN(CC)C(=O)C2CC2)c1.CO.[Li+].[OH-]>>CCN(Cc1cc(F)ccc1-c1cncc(CC(=O)O)c1)C(=O)C1CC1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CNC.COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)[nH]c2c1OCCCCCCBr.CS(C)=O>>COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)[nH]c2c1OCCCCCCN(C)C",
        "output": "73"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C(=O)Cl.ClCCl.Clc1cccc(C#CC2=NOC3(CCNC3)C2)c1>>CN(C)C(=O)N1CCC2(CC(C#Cc3cccc(Cl)c3)=NO2)C1",
        "output": "258"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.CO.NC(C(=O)O)C(c1ccccc1)N(C=O)Cc1ccccc1.O=S(Cl)Cl>>COC(=O)C(N)C(c1ccccc1)N(C=O)Cc1ccccc1",
        "output": "195"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CCOC(C)=O.COC(=O)Cc1nc(Cl)c(F)c(OC)n1.O>>COC(=O)Cc1nc(OC)c(F)c(N2CCOCC2)n1",
        "output": "162"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCOc1cc(F)c(Cn2nc(-c3ncc(OC)c(Nc4ccc(O[Si](C)(C)C(C)(C)C)cc4)n3)c3ccccc32)c(F)c1.Cl>>CCOc1cc(F)c(Cn2nc(-c3ncc(OC)c(Nc4ccc(O)cc4)n3)c3ccccc32)c(F)c1",
        "output": "754"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CCN(CC)CC.CCOC(=O)c1cn2c(cc1=O)-c1cc(OCC)c(OCC)cc1CC2CN.ClCCl.O>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OCC)c(OCC)cc1CC2CNC(C)=O",
        "output": "45"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1ccc2nccc(C(O)CN3CCOC(CN)C3)c2c1.ClCCl.O=Cc1ccc2c(c1)OCO2.[BH4-].[Na+]>>COc1ccc2nccc(C(O)CN3CCOC(CNCc4ccc5c(c4)OCO5)C3)c2c1",
        "output": "468"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CC(n2cc(B3OC(C)(C)C(C)(C)O3)cn2)C1.CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(Br)ccc1-2>>CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cnn(C4CN(C(=O)OC(C)(C)C)C4)c3)ccc1-2",
        "output": "971"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.O.O=C1COc2cccc(OCc3ccccc3)c2N1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>c1ccc(COc2cccc3c2NCCO3)cc1",
        "output": "363"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccccc1B(O)O.O=S(=O)(NCCCCCO)c1ccc(Br)cc1>>COc1ccccc1-c1ccc(S(=O)(=O)NCCCCCO)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cc1ccc(-c2nc(CCN3C(=O)c4ccccc4C3=O)cn2C(c2nc3cc(Cl)ccc3c(=O)n2Cc2ccccc2)C(C)C)cc1.NN>>Cc1ccc(-c2nc(CCN)cn2C(c2nc3cc(Cl)ccc3c(=O)n2Cc2ccccc2)C(C)C)cc1",
        "output": "242"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1sc(C2CCNCC2)nc1CCc1ccccc1.Cc1cc(C(F)(F)F)nn1CC(=O)O>>Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(CCc3ccccc3)c(Br)s2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CC(C)CCCCCCCBr.O=C(Cc1ccccc1)c1cc(O)ccc1O.O=C([O-])[O-].[K+].[K+]>>CC(C)CCCCCCCOc1ccc(O)c(C(=O)Cc2ccccc2)c1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)C(=O)Cl.CCN(C(C)C)C(C)C.COC(=O)c1ccc(F)c(CN)c1Cl.ClCCl>>COC(=O)c1ccc(F)c(CNC(=O)C(C)(C)C)c1Cl",
        "output": "206"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cccc2nc(C(C)C)n(Cc3ccc(-c4ccccc4-c4nnn[nH]4)cc3)c12.CO.[Na+].[OH-]>>CC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1",
        "output": "5"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NC12CC3CC(C1)C(Nc1c(C(=O)C4CC4)cnc4ccc(Br)cc14)C(C3)C2.COc1cc(B2OC(C)(C)C(C)(C)O2)cc(Cl)c1O>>COc1cc(-c2ccc3ncc(C(=O)C4CC4)c(NC4C5CC6CC4CC(NC(=O)OC(C)(C)C)(C6)C5)c3c2)cc(Cl)c1O",
        "output": "933"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)NC(=O)c1csc(CN2CCN(C(=O)OC(C)(C)C)CC2)n1.ClCCl.O=C(O)C(F)(F)F>>CC(C)(C)NC(=O)c1csc(CN2CCNCC2)n1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)N1CC2CCN(Cc3ccccc3)C2C1.Cl>>c1ccc(CN2CCC3CNCC32)cc1",
        "output": "283"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1nc2cc(N)cnc2n1C.Cl.Cl.O=C(O)c1cc2cc(F)ccc2n1Cc1cccc(F)c1.On1nnc2ccccc21>>Cc1nc2cc(NC(=O)c3cc4cc(F)ccc4n3Cc3cccc(F)c3)cnc2n1C",
        "output": "776"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)O.CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)[O-].CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)[O-].O.[Ca+2]>>CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)O",
        "output": "151"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)CN(Cc1ccc(F)cc1[N+](=O)[O-])C(=O)OC(C)(C)C.Cl.O.[Li+].[OH-]>>CC(C)(C)OC(=O)N(CC(=O)O)Cc1ccc(F)cc1[N+](=O)[O-]",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CN1CCN(C2CCNCC2)CC1.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)c(OC(F)F)c1.[K+].[K+]>>CN1CCN(C2CCN(c3ccc([N+](=O)[O-])cc3OC(F)F)CC2)CC1",
        "output": "105"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].CCO.COc1cc(N2CCC(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl.ClCCl.N.[BH4-].[NH4+].[Na+].[OH-].[Ti+4]>>COc1cc(N2CCC(C(N)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl",
        "output": "63"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#Cc1cnn2ccc(-c3ccc(C(=O)O)cc3)nc12.CC(C)(C)OC(=O)N1CCNCC1.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[P-](F)(F)(F)(F)F>>C#Cc1cnn2ccc(-c3ccc(C(=O)N4CCN(C(=O)OC(C)(C)C)CC4)cc3)nc12",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1Cn2ncc(N3CC(C)(C)CC3=O)c2CN1.Fc1ccc(-c2cnn3c2CNCC3)cc1.O=C(Nc1ccc(F)c(Cl)c1)Oc1ccccc1.O=C(Nc1ccc(F)c(Cl)n1)N1CCn2ncc(-c3ccc(F)cc3)c2C1>>CC1Cn2ncc(N3CC(C)(C)CC3=O)c2CN1C(=O)Nc1ccc(F)c(Cl)c1",
        "output": "525"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)CC(=O)Cl.ClCCl.NC(CO)(CO)CO.NCCc1cccs1>>CC(C)(C)CC(=O)NCCc1cccs1",
        "output": "45"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cc(-c2nc(N)nc(C)c2C#Cc2ccc(N)nc2)ccc1Cl.O.[Li+].[OH-]>>Cc1nc(N)nc(-c2ccc(Cl)c(C(=O)O)c2)c1C#Cc1ccc(N)nc1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(C(CO)Sc2ccc3c(c2)C=CC(C)(C)O3)cc(OC)c1OC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.c1ccncc1>>COc1cc(C(COS(=O)(=O)c2ccc(C)cc2)Sc2ccc3c(c2)C=CC(C)(C)O3)cc(OC)c1OC",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N1CCN(c2nc(N)nc3ccc(Br)cc23)CC1.CC(=O)Nc1ccc(B(O)O)cc1>>CC(=O)Nc1ccc(-c2ccc3nc(N)nc(N4CCN(C(C)=O)CC4)c3c2)cc1",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CCCl.CCO.CC[O-].Cl.O=C([O-])[O-].O=[N+]([O-])c1ccc(O)cc1.[K+].[K+].[Na+]>>CCN(CC)CCOc1ccc([N+](=O)[O-])cc1",
        "output": "74"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NN.O.O=C(c1ccccc1)N1CCc2nnc(Cl)cc2C1>>NNc1cc2c(nn1)CCN(C(=O)c1ccccc1)C2",
        "output": "284"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)CCO.Nc1cccc(Cl)n1.[Na]>>CN(C)CCOc1cccc(N)n1",
        "output": "433"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CNC(C)C.C[Si](C)(C)CCN1C(=O)CN(c2ccc(CCC(=O)O)cc2OCc2ccccc2)S1(=O)=O.Cl.O.On1nnc2cccnc21>>CC(C)N(C)C(=O)CCc1ccc(N2CC(=O)N(CC[Si](C)(C)C)S2(=O)=O)c(OCc2ccccc2)c1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)CCCc1cccc(OCc2c(C)cccc2C)c1.[Na+].[OH-]>>Cc1cccc(C)c1COc1cccc(CCCC(=O)O)c1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)C1CC(=O)N(c2ccc(OCc3cccc(F)c3)cc2)C1.Cl.[Na+].[OH-]>>O=C(O)C1CC(=O)N(c2ccc(OCc3cccc(F)c3)cc2)C1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN[C@H](CN1CC[C@H](O)C1)c1cccc(C#C[Si](C)(C)C)c1.CO.Cl.O.[K+].[OH-]>>C#Cc1cccc([C@@H](CN2CC[C@H](O)C2)NC)c1",
        "output": "337"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.Brc1ccc2[nH]c3ccc(Br)cc3c2c1.CC(C)=O.CCCC[N+](CCCC)(CCCC)CCCC.O=S(=O)([O-])O.[K+].[OH-]>>Brc1ccc2c(c1)c1cc(Br)ccc1n2Cc1ccccc1",
        "output": "528"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCn1c(-c2ccccc2)nc2cc(C(=O)OC)ccc21.Cc1ccccc1.O.[Na+].[OH-]>>CCCn1c(-c2ccccc2)nc2cc(CO)ccc21",
        "output": "444"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOc1ccc(C(=O)CCC(=O)Nc2cc(-c3ccccc3)c3ccc(/C=C/C(=O)OC(C)(C)C)cc3n2)cc1OCC.O=C(O)C(F)(F)F>>CCOc1ccc(C(=O)CCC(=O)Nc2cc(-c3ccccc3)c3ccc(/C=C/C(=O)O)cc3n2)cc1OCC",
        "output": "158"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(C)=O.CCCc1c(OCCCCCBr)ccc(C(C)=O)c1O.CCOC(=O)CCC1(CCC(=O)OCC)OCC(CS)S1>>CCCc1c(OCCCCCSCC2COC(CCC(=O)OCC)(CCC(=O)OCC)S2)ccc(C(C)=O)c1O",
        "output": "185"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.COCC(C)O.C[Si](C)(C)[N-][Si](C)(C)C.N#Cc1cc(F)cc(Br)c1.O.[Na+]>>COCC(C)Oc1cc(Br)cc(C#N)c1",
        "output": "485"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=C(NC1CCOCC1)c1cccc([N+](=O)[O-])c1.O=C[O-].[NH4+].[Pd]>>Nc1cccc(C(=O)NC2CCOCC2)c1",
        "output": "489"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Nc1cccc(C2CCNCC2)c1.CC(=O)O.CC(C)(C)OC(=O)N1CC(C=O)C1.CCOC(C)=O.CO.[BH4-].[Na+].[Na+].[OH-]>>CC(=O)Nc1cccc(C2CCN(CC3CN(C(=O)OC(C)(C)C)C3)CC2)c1",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)c1ccc(-c2ccc(OC)c(-c3ccc(C(F)(F)F)cc3CN3CC[C@@H](c4ccccc4OC)OC3=O)c2)c(C)c1.[K+].[OH-]>>COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)cc1CN1CC[C@@H](c2ccccc2OC)OC1=O",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCC(C)NC(=O)c1ccc(Cl)cc1>>CCCC(C)NCc1ccc(Cl)cc1",
        "output": "215"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1c([C@@H](O)CN2CCNC3CC32)ccc2c1COC2=O.F[P-](F)(F)(F)(F)F.O.O=C(O)C(F)(F)F.O=C(O)Cc1ccc(-n2cnnn2)nc1>>Cc1c([C@@H](O)CN2CCN(C(=O)Cc3ccc(-n4cnnn4)nc3)C3CC32)ccc2c1COC2=O",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOCC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O=C(OCc1ccccc1)N1CCC[C@H]1CO>>Cc1ccc(S(=O)(=O)OC[C@@H]2CCCN2C(=O)OCc2ccccc2)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1c[nH]c(=O)c2ccccc12.O=P(Cl)(Cl)Cl>>COC(=O)c1cnc(Cl)c2ccccc12",
        "output": "100"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)COc1cc(C)c(Cc2ccc(O)c(S(=O)(=O)c3ccc(F)cc3)c2)c(C)c1.[Na+].[OH-]>>Cc1cc(OCC(=O)O)cc(C)c1Cc1ccc(O)c(S(=O)(=O)c2ccc(F)cc2)c1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cc1cc(Br)ccc1C(=O)O.O=C([O-])O.O=S(=O)(O)O.[Na+]>>COC(=O)c1ccc(Br)cc1C",
        "output": "33"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CC1OB(O)c2cc(O)cc(Cl)c21.CN(C)C=O.Cl.Clc1cnccn1.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)CC1OB(O)c2cc(Oc3cnccn3)cc(Cl)c21",
        "output": "210"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)OCCCS(=O)(=O)NC(=O)c1ccc([C@H](C)NC(=O)c2cccc3ccn(Cc4ccc(Cl)cc4)c23)cc1.CO.Cl.O.[Na+].[OH-]>>C[C@H](NC(=O)c1cccc2ccn(Cc3ccc(Cl)cc3)c12)c1ccc(C(=O)NS(=O)(=O)CCCO)cc1",
        "output": "225"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NC1(c2ccc(-c3nc(Cl)c([N+](=O)[O-])cc3-c3ccccc3)cc2)CCC1.CCN(CC)CC.CCO.CCOC(=O)CCN.Cl.O>>CCOC(=O)CCNc1nc(-c2ccc(C3(NC(=O)OC(C)(C)C)CCC3)cc2)c(-c2ccccc2)cc1[N+](=O)[O-]",
        "output": "70"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=O.Cc1c(N2CCNC(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12.O=C([O-])O.O=CO.O=C[O-].[Na+].[Na+]>>Cc1c(N2CCN(C)C(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12",
        "output": "217"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)N=NC(=O)OCC.CCOC(Cc1ccc(O)c2ccsc12)C(=O)OC.COc1ccc(-c2nc(CCO)c(C)o2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(Cc1ccc(OCCc2nc(-c3ccc(OC)cc3)oc2C)c2ccsc12)C(=O)OC",
        "output": "478"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC(C)=O.CC(Cl)Cl.NCCCCO.[BH3-]OC(C)=O.[Na+]>>CC(C)NCCCCO",
        "output": "236"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(=O)C(Cc1ccc(OCCO)cc1)Oc1ccc(F)cc1.CS(=O)(=O)Cl>>CCOC(=O)C(Cc1ccc(OCCOS(C)(=O)=O)cc1)Oc1ccc(F)cc1",
        "output": "0"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cnn(-c2cnc(-c3ccccc3)c(C#N)c2)c1.CO.Cl.[Na+].[OH-]>>N#Cc1cc(-n2cc(C(=O)O)cn2)cnc1-c1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#CCC(C)O.CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O.c1c[nH]cn1>>C#CCC(C)O[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.C[Si](C)(C)I.Nc1nccc(-c2c(-c3ccc(F)cc3)nc3cc(C4CCN(C(=O)OCc5ccccc5)CC4)ccn23)n1>>Nc1nccc(-c2c(-c3ccc(F)cc3)nc3cc(C4CCNCC4)ccn23)n1",
        "output": "428"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nn1nc(C(F)(F)F)c2ccccc2c1=O.O=C(O)Cc1ccc2ccccc2c1>>O=C(Cc1ccc2ccccc2c1)Nn1nc(C(F)(F)F)c2ccccc2c1=O",
        "output": "459"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)C(C)(N)Cc1c[nH]c2ccccc12.Cc1cc(C(N)=O)ccc1C#Cc1ccc(OC(F)(F)F)c(C(=O)O)c1.O.On1nnc2ccccc21>>COC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)c1cc(C#Cc2ccc(C(N)=O)cc2C)ccc1OC(F)(F)F",
        "output": "652"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.O=C(c1ccc(Cl)cc1)c1ccccc1Cl.[BH4-].[Na+]>>OC(c1ccc(Cl)cc1)c1ccccc1Cl",
        "output": "157"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cn1cc(Br)c(-c2cccc(N)c2)n1.F[P-](F)(F)(F)(F)F.O=C(O)Cc1ccc(OC(F)(F)F)cc1.On1nnc2ccccc21>>Cn1cc(Br)c(-c2cccc(NC(=O)Cc3ccc(OC(F)(F)F)cc3)c2)n1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.Cl[Pd]Cl.Clc1cc(Cl)ncn1.O.O=C([O-])[O-].OB(O)c1ccc(C(F)(F)F)cc1F.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Fc1cc(C(F)(F)F)ccc1-c1cc(Cl)ncn1",
        "output": "884"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.ClCCl.On1nnc2ccccc21>>C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCCC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCc1ccc(Cc2ccc(CC(=O)O)cc2OCc2ccccc2)cc1.Cl.O=C([O-])O.[NH4+].c1ccncc1>>CCc1ccc(Cc2ccc(CC(N)=O)cc2OCc2ccccc2)cc1",
        "output": "313"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[Zn]OC(C)=O.CC1Cc2cc(Br)ccc2N(c2cccnc2)CCO1.CN(C)C=O.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[C-]#N.[C-]#N.[Pd].[Pd].[Zn+2].[Zn]>>CC1Cc2cc(C#N)ccc2N(c2cccnc2)CCO1",
        "output": "65"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCC2=NCCCN2CC1.CC#N.CI.O=C(O)c1ccc2[nH]ccc2c1>>COC(=O)c1ccc2[nH]ccc2c1",
        "output": "415"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)CC(=O)O.Cl.Nc1ncnn2c([C@H]3CCCNC3)cc(-c3ccc4cn(Cc5ccccc5)nc4c3)c12.On1nnc2ccccc21>>CN(C)CC(=O)N1CCC[C@H](c2cc(-c3ccc4cn(Cc5ccccc5)nc4c3)c3c(N)ncnn23)C1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)Cn1ncc2cc([N+](=O)[O-])ccc21.CCO.O.[Cl-].[Fe].[NH4+]>>CC(C)Cn1ncc2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.Nc1ccc([N+](=O)[O-])cc1C(=O)c1ccccc1F.c1ccncc1>>Cc1ccc(S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2C(=O)c2ccccc2F)cc1",
        "output": "68"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)[O-].CCOC(C)=O.Cl.N#Cc1cc(C=O)ccc1-n1cncn1.NO.O.O.[Na+]>>N#Cc1cc(C=NO)ccc1-n1cncn1",
        "output": "30"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NC1(c2ccccc2)CCN(Cc2ccccc2)C1.CO.[H][H].[Pd]>>CC(C)(C)OC(=O)NC1(c2ccccc2)CCNC1",
        "output": "84"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)CC(C)c1ccc(OCCOC)cc1O.CN(C)C=O.FC(F)(F)c1cnc(Cl)c(Cl)c1.[Cl-].[H-].[NH4+].[Na+]>>CCOC(=O)CC(C)c1ccc(OCCOC)cc1Oc1ncc(C(F)(F)F)cc1Cl",
        "output": "516"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.COC(=O)c1ccc(OS(=O)(=O)C(F)(F)F)cc1OC.O.O=S(=O)(O)O>>COc1cc(OS(=O)(=O)C(F)(F)F)ccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCCCCCCCCCCC(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.ClCCl.O=C([O-])C(F)(F)F.O=C1c2ccccc2C(=O)N1OCCC1CCNCC1>>CCCCCCCCCCCCCCCC(=O)N1CCC(CCON2C(=O)c3ccccc3C2=O)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COCCOCCOCCOCCS(=O)(=O)CCC(C)(C)NC(=O)OCc1ccccc1>>COCCOCCOCCOCCS(=O)(=O)CCC(C)(C)N",
        "output": "574"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc2[nH]cc(C#N)c(=O)c2c1.ClCC1CCCCC1>>COc1ccc2c(c1)c(=O)c(C#N)cn2CC1CCCCC1",
        "output": "42"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.CN(C)C=O.CS(=O)(=O)O.CS(C)=O.F[P-](F)(F)(F)(F)F.NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O.O=C(O)C(F)(F)c1ccccc1OC(F)(F)F>>O=C1CCC(N2Cc3cc(CNC(=O)C(F)(F)c4ccccc4OC(F)(F)F)ccc3C2=O)C(=O)N1",
        "output": "599"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CN1CCCC1=O.COc1cc(C(=O)N2CCc3cc(F)ccc32)cc(Cl)n1.COc1ccc2c(c1)CCN(C1CCNCC1)C(=O)N2.O=C([O-])[O-].[K+].[K+]>>COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)N4CCc5cc(F)ccc54)cc(OC)n3)CC1)C(=O)N2",
        "output": "220"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)N1Cc2[nH]c3ccc(F)cc3c2C1.Fc1ccc(Br)cc1.NCCN.O.O=C([O-])[O-].[Na+].[Na+]>>CCOC(=O)N1Cc2c(n(-c3ccc(F)cc3)c3ccc(F)cc23)C1",
        "output": "349"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCI.CCOC(=O)c1sc(CC)c(C#N)c1-c1ccc(-c2ccccc2O)cc1.CN(C)C=O.Cl.O=C([O-])[O-].[K+].[K+]>>CCCOc1ccccc1-c1ccc(-c2c(C(=O)OCC)sc(CC)c2C#N)cc1",
        "output": "198"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cl.ClCCl.O=C([O-])O.OCCCCc1cccc2nccn12.[Na+]>>CS(=O)(=O)OCCCCc1cccc2nccn12",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1cccc(N)c1.F[P-](F)(F)(F)(F)F.Nc1ncc2c(n1)CCN(c1cccc(C(=O)O)c1)C2>>Cc1cccc(NC(=O)c2cccc(N3CCc4nc(N)ncc4C3)c2)c1",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)C[AlH]CC(C)C.CCOC(=O)C=C(c1sccc1C)c1sccc1C.ClCCl.[Cl-].[NH4+]>>Cc1ccsc1C(=CCO)c1sccc1C",
        "output": "150"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCOc1ccc(F)c2c(=O)c(-c3ccc(OC)cc3)cn(CC(=O)NCCN3CCOCC3)c12.CCOC(C)=O.CI.CN(C)C=O.O.[H-].[Na+]>>CCCOc1ccc(F)c2c(=O)c(-c3ccc(OC)cc3)cn(CC(=O)N(C)CCN3CCOCC3)c12",
        "output": "83"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.Cc1nn(C)c(-n2ccc3cc(Cl)ccc32)c1CCO.O>>Cc1nn(C)c(-n2ccc3cc(Cl)ccc32)c1CCOS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CCN.CN1CCOCC1.COc1nc(Cl)nc(OC)n1.Cc1cc(SC(CCCC(F)(F)F)c2ccc(C(=O)O)cc2)cc(C)c1Br.Cl.ClCCl.O>>CCOC(=O)CCNC(=O)c1ccc(C(CCCC(F)(F)F)Sc2cc(C)c(Br)c(C)c2)cc1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCN(c2nc(N)nc3cc(C(=O)O)ccc23)CC1.F[P-](F)(F)(F)(F)F.NC(Cc1ccc(-c2ccccc2)cc1)c1nccs1>>CN1CCN(c2nc(N)nc3cc(C(=O)NC(Cc4ccc(-c5ccccc5)cc4)c4nccs4)ccc23)CC1",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCO.CCOC(C)=O.CN(C)C=O.CN1CCCC1=O.COc1cc(C(C)c2cccc3nc(Nc4ccc(C(F)(F)F)cc4)nn23)ccn1.CS(=O)(=O)OS(C)(=O)=O.N#N.O.O=C([O-])O.[H][H].[Na+].[Pd]>>CC(c1cc[nH]c(=O)c1)c1cccc2nc(Nc3ccc(C(F)(F)F)cc3)nn12",
        "output": "758"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCC.O.O=Cc1ccc(F)c(Oc2ccccc2)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OCc1ccc(F)c(Oc2ccccc2)c1",
        "output": "356"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COCC(NC(=O)OC(C)(C)C)c1cccc(CCNC(=O)OCc2ccccc2)c1.[Pd]>>COCC(NC(=O)OC(C)(C)C)c1cccc(CCN)c1",
        "output": "574"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)Cl.N.O.O=C(O)COCCN1CCN2c3ccccc3Cc3ccccc3C2C1>>NC(=O)COCCN1CCN2c3ccccc3Cc3ccccc3C2C1",
        "output": "313"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.C[Si](C)(C)CCOCn1c(-c2cc(C(F)(F)F)ccn2)nc2ccc(Br)cc21.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[K+].[Pd].[Pd]>>CC1(C)OB(c2ccc3nc(-c4cc(C(F)(F)F)ccn4)n(COCC[Si](C)(C)C)c3c2)OC1(C)C",
        "output": "934"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "FC(F)(F)c1cc(Cl)nc(-c2ccccn2)n1.Nc1cc(O)ccc1Cl>>Oc1ccc(Cl)c(Nc2cc(C(F)(F)F)nc(-c3ccccn3)n2)c1",
        "output": "161"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CCN(C(C)C)C(C)C.CN(C)C=O.CNCCc1ccccc1.C[C@H](NC(=O)OC(C)(C)C)C(=O)O.F[P-](F)(F)(F)(F)F>>C[C@H](NC(=O)OC(C)(C)C)C(=O)N(C)CCc1ccccc1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.O=[N+]([O-])c1ccc2[nH]ncc2c1>>CC(C)(C)OC(=O)n1ncc2cc([N+](=O)[O-])ccc21",
        "output": "841"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Cc1ccc(N)cc1-c1ccc2c(c1)CC(C)(C)C2=O.O=C=NCc1ccccc1>>Cc1ccc(NC(=O)NCc2ccccc2)cc1-c1ccc2c(c1)CC(C)(C)C2=O",
        "output": "888"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNCC1.CCO.Cc1[nH]c(C=O)c(C)c1C(=O)N1CCN(C)CC1.Cl.O=C1Cc2c(cccc2-c2cncc(C(=O)O)c2)N1>>Cc1[nH]c(C=C2C(=O)Nc3cccc(-c4cncc(C(=O)O)c4)c32)c(C)c1C(=O)N1CCN(C)CC1",
        "output": "440"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCOC(C)=O.CN1CCN(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cl.Cl[Pd]Cl.O=C(O)c1n[nH]c2cc(Cl)c(Br)cc12.O=C([O-])[O-].[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CN1CCN(c2ccc(-c3cc4c(C(=O)O)n[nH]c4cc3Cl)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC(=O)c1ccc(O)c(CCCc2ccccc2)c1O.CCOCC.COC(=O)CCCCCOc1cccc(CCCCCCOS(C)(=O)=O)c1CCC(=O)OC.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>COC(=O)CCCCCOc1cccc(CCCCCCOc2ccc(C(C)=O)c(O)c2CCCc2ccccc2)c1CCC(=O)OC",
        "output": "702"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc2c(c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O.Cl.c1ccncc1>>CC1(C)c2cc(O)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C1COCCO1.CCOC(=O)c1ccc2nc(N3CC[C@@H](N4CCCCC4)C3)sc2c1.CCOC(C)=O.CO.CO.Cl.O.O.[Li+].[OH-]>>O=C(O)c1ccc2nc(N3CC[C@@H](N4CCCCC4)C3)sc2c1",
        "output": "5"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Clc1cccc(CC2CCCN2)c1.O=C(O)c1nc2cc(F)c(F)cc2nc1O>>O=C(c1nc2cc(F)c(F)cc2nc1O)N1CCCC1Cc1cccc(Cl)c1",
        "output": "729"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.O=C(NCC(=O)N1CCNCC1)c1ccc(-c2ccccc2)cc1.O=C(O)c1ccccc1Cl.On1nnc2ccccc21>>O=C(NCC(=O)N1CCN(C(=O)c2ccccc2Cl)CC1)c1ccc(-c2ccccc2)cc1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1nc(N2CCN(C(=O)COc3ccc(Cl)cc3)CC2)c2nc(Cl)ccc2n1.OB(O)c1cccc(F)c1>>Nc1nc(N2CCN(C(=O)COc3ccc(Cl)cc3)CC2)c2nc(-c3cccc(F)c3)ccc2n1",
        "output": "865"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COCCOC[C@@H](N)CC1CC1.O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1>>COCCOC[C@H](CC1CC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1",
        "output": "137"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)C1=C(C)N=C(C)N(CC(=O)OCc2ccccc2)C1c1cc(F)c(F)c(F)c1.O.[Pd]>>COC(=O)C1=C(C)N=C(C)N(CC(=O)O)C1c1cc(F)c(F)c(F)c1",
        "output": "186"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.COCCNC(=O)c1ccc2cncc(Br)c2n1.COc1cccc(B(O)O)c1.Cl[Pd]Cl.O.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COCCNC(=O)c1ccc2cncc(-c3cccc(OC)c3)c2n1",
        "output": "871"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)(C)OC(=O)c1cc(C2CC2)c(O[C@@H]2CCCNC2)cc1F.CC(C)N(C(=O)CBr)C(C)C.O=C([O-])[O-].[K+].[K+]>>CC(C)N(C(=O)CN1CCC[C@@H](Oc2cc(F)c(C(=O)OC(C)(C)C)cc2C2CC2)C1)C(C)C",
        "output": "443"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.O.O=C1CC2CCCC(C1)N2Cc1ccccc1.[AlH4-].[Li+].[Na+].[OH-]>>OC1CC2CCCC(C1)N2Cc1ccccc1",
        "output": "91"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.Nc1cc(F)ccc1CO.O=C(Cl)CCc1ccccc1>>O=C(CCc1ccccc1)Nc1cc(F)ccc1CO",
        "output": "9"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCSc1ccc(Cl)cc1NNC(=O)c1cc(C)c(Br)cc1[N+](=O)[O-].N#Cc1ccc(Sc2ccccc2)c(NN)c1.Nc1ccc(C(F)(F)F)cc1C(=O)O>>N#Cc1ccc(Sc2ccccc2)c(NNC(=O)c2cc(C(F)(F)F)ccc2N)c1",
        "output": "55"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)O.CCCC1CC=C(c2ccc(Br)cc2F)CC1.Cc1ccccc1.[Pd]>>CCCC1CCC(c2ccc(Br)cc2F)CC1",
        "output": "249"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cl.Cl.N#CCC(=O)O.N[C@@H]1CC[C@@H](CCN2CCCCC2c2coc3cccc-3c2)CC1>>N#CCC(=O)N[C@@H]1CC[C@@H](CCN2CCCCC2c2coc3cccc-3c2)CC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.CN(C)C=O.CNC.Cc1cc(C)c(-c2ccc(C[C@H](NC(=O)[C@@H]3CC[C@@H](CNC(=O)OC(C)(C)C)CC3)C(=O)Nc3ccc(-c4nn[nH]n4)cc3)cc2)cc1C(=O)O.F[P-](F)(F)(F)(F)F>>Cc1cc(C)c(-c2ccc(C[C@H](NC(=O)[C@@H]3CC[C@@H](CNC(=O)OC(C)(C)C)CC3)C(=O)Nc3ccc(-c4nn[nH]n4)cc3)cc2)cc1C(=O)N(C)C",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1ccc(Cl)cc1.CCO.O=Cc1ccccc1>>O=C(C=Cc1ccccc1)c1ccc(Cl)cc1",
        "output": "295"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#Cc1ccc(NC2CC2)nn1.CN1CCN(Cc2ccc3nc(-c4ccc(Cl)c(I)c4)[nH]c3c2)CC1>>CN1CCN(Cc2ccc3nc(-c4ccc(Cl)c(C#Cc5ccc(NC6CC6)nn5)c4)[nH]c3c2)CC1",
        "output": "664"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClCCl.Cn1ccc2c3nc(-c4ccc(N)cc4)nc(N4CCOCC4)c3ccc21>>CC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3ccc4c(ccn4C)c3n2)cc1",
        "output": "9"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CO.[OH-].[OH-].[Pd+2].c1ccc(COc2ccc(-c3nnc(C4(c5cccs5)CCC4)n3C3CC3)cc2)cc1>>Oc1ccc(-c2nnc(C3(c4cccs4)CCC3)n2C2CC2)cc1",
        "output": "23"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCN(CC)CC.CCN(CC)c1ccc(C(=O)O)cc1.Nc1ccc(Cl)cc1N1CCN(CCC(F)(F)F)CC1.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>>CCN(CC)c1ccc(C(=O)Nc2ccc(Cl)cc2N2CCN(CCC(F)(F)F)CC2)cc1",
        "output": "50"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)CN1CCn2c(CC3(c4ccccc4)CCCC3)nc(=O)c(OCc3ccccc3)c2C1=O.O=C1c2c(O)c(=O)nc(CC3(c4ccccc4)CCCC3)n2CCN1C1CC1>>CC(C)(C)CN1CCn2c(CC3(c4ccccc4)CCCC3)nc(=O)c(O)c2C1=O",
        "output": "492"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "B.C1CCOC1.C1CCOC1.Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1CC(=O)O>>Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1CCO",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.CSC.Cc1cc(C(F)(F)C(=O)N2CCOCC2)cc([N+](=O)[O-])c1N.N#N.O=C([O-])O.[Na+]>>Cc1cc(C(F)(F)CN2CCOCC2)cc([N+](=O)[O-])c1N",
        "output": "112"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.OCc1c(Cl)cc(Cl)cc1Cl>>O=Cc1c(Cl)cc(Cl)cc1Cl",
        "output": "179"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N1Cc2cc(F)c(Cl)nc2C=Cc2cc(Cl)ccc21.COc1ccc(-c2nc3c(cc2F)CN(C(C)=O)c2ccccc2C=C3)cn1.COc1ccc(B2OC(C)(C)C(C)(C)O2)cn1>>COc1ccc(-c2nc3c(cc2F)CN(C(C)=O)c2ccc(Cl)cc2C=C3)cn1",
        "output": "968"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].CCC(=O)c1cc(Cl)c(C)c(Br)c1OC.CCO.N.[BH4-].[Na+].[Ti+4]>>CCC(N)c1cc(Cl)c(C)c(Br)c1OC",
        "output": "552"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N(C)C.CC(C)(C#N)c1cccc(C(=O)Cl)c1.Cl.Cl.Nc1cccc(Oc2ccc(N)nc2)c1.O=C([O-])O.[Na+]>>CC(C)(C#N)c1cccc(C(=O)Nc2cccc(Oc3ccc(N)nc3)c2)c1",
        "output": "11"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCC(CN2CCOCC2)NC1.O=C1Nc2ccccc2N(C(=O)CCl)c2ccccc21>>O=C1Nc2ccccc2N(C(=O)CN2CCCCC2CN2CCOCC2)c2ccccc21",
        "output": "340"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CO.CS(=O)(=O)c1ccc(C(=O)O)cc1.F[P-](F)(F)(F)(F)F.N#Cc1cc(Cl)cc(Oc2c(Cl)ccc(CN)c2F)c1>>CS(=O)(=O)c1ccc(C(=O)NCc2ccc(Cl)c(Oc3cc(Cl)cc(C#N)c3)c2F)cc1",
        "output": "753"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCBr.CN(C)C=O.COC(=O)c1ccc(O)c(OC)c1.O=C([O-])[O-].[K+].[K+]>>CCOc1ccc(C(=O)OC)cc1OC",
        "output": "385"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.COc1cc(OC)nc(CN)n1.ClCCl.O=C(O)c1cnccc1C(F)(F)F.O=S(Cl)Cl>>COc1cc(OC)nc(CNC(=O)c2cnccc2C(F)(F)F)n1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(-c3cc(C4CC4)cc(Cl)n3)cn2)CC1.O=C(O)C(F)(F)F>>Clc1cc(C2CC2)cc(-c2ccc(N3CCNCC3)nc2)n1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCC[N+](CCC)(CCC)CCC.CCOc1cc2c(cc1/C(CC)=C(/F)CO)C(C)(C)CCC2(C)C.C[N+]1([O-])CCOCC1.ClCCl>>CCOc1cc2c(cc1/C(CC)=C(/F)C=O)C(C)(C)CCC2(C)C",
        "output": "183"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.C=C(C)CC1C(=O)N(CC(=O)OCC)CC(c2ccccc2Cl)c2cc(Cl)ccc21.Cl.ClCCl.O.[Na+].[OH-]>>C=C(C)CC1C(=O)N(CC(=O)O)CC(c2ccccc2Cl)c2cc(Cl)ccc21",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CSc1cc(-c2ccccc2OCc2ccccc2)[nH]c(=O)c1C#N.ClCCl.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1cc(-c2ccccc2OCc2ccccc2)[nH]c(=O)c1C#N",
        "output": "500"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COCCCCN.Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)O)cn2)c1O.Cl.On1nnc2ccccc21.[Cl-].[NH4+]>>COCCCCNC(=O)c1ccc(-n2ncc(-c3ccc(C#N)cc3C)c2O)nc1",
        "output": "674"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CNC(C)(C)C.COc1ccc(-n2nc(C(=O)O)cc2-c2ccccn2)nn1>>COc1ccc(-n2nc(C(=O)N(C)C(C)(C)C)cc2-c2ccccn2)nn1",
        "output": "663"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)c1cc(Cl)ccn1.CC(C)(C)[O-].Nc1ccc(O)cc1F.[K+]>>CC(C)(C)OC(=O)c1cc(Oc2ccc(N)c(F)c2)ccn1",
        "output": "351"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CO.COC1C(=O)CCC(O)(CSCc2ccccc2CO)C1C1(C)OC1CC=C(C)C.[BH3-]C#N.[NH4+].[Na+]>>COC1C(N)CCC(O)(CSCc2ccccc2CO)C1C1(C)OC1CC=C(C)C",
        "output": "63"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cc1cc(N)ccc1N1C(=O)c2ccc(Cl)cc2C1=O.O=C=Nc1ccccc1>>Cc1cc(NC(=O)Nc2ccccc2)ccc1N1C(=O)c2ccc(Cl)cc2C1=O",
        "output": "473"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=C(C)C1CCC(C)C1(C)C=O.CC(C)O.[BH4-].[Na+]>>C=C(C)C1CCC(C)C1(C)CO",
        "output": "223"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN=C=NCCCN(C)C.Cl.ClCCl.N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)c1nc2ccccc2s1.O.O=C(O)C1CCCCC1.On1nnc2ccccc21>>O=C(NCCCC[C@H](NC(=O)C1CCCCC1)C(=O)c1nc2ccccc2s1)OCc1ccccc1",
        "output": "645"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNC1.C1COCCO1.Cc1[nH]c2ccc(CCOS(C)(=O)=O)cc2c1C(=O)OC(C)c1ccc(F)cc1>>Cc1[nH]c2ccc(CCN3CCCC3)cc2c1C(=O)OC(C)c1ccc(F)cc1",
        "output": "496"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrBr.CC(=O)Nc1ccccc1C(C)=O.ClC(Cl)Cl>>CC(=O)Nc1ccccc1C(=O)CBr",
        "output": "173"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(O)CN.CCOC(C)=O.CO.O>>CC(O)CNC(=O)OC(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)CN.Cc1ccc(F)c(Cl)n1>>Cc1ccc(F)c(NCC(C)(C)C)n1",
        "output": "70"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(CCO)CC1=CCCCC1.Cc1ccccc1.O.O=C([O-])O.[Br-].[Na+].[Na+].[Na+].[O-]Cl>>CC(CC=O)CC1=CCCCC1",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cccc(Oc2ccc([N+](=O)[O-])nc2)c1>>CC(C)(C)OC(=O)Nc1cccc(Oc2ccc([N+](=O)[O-])nc2)c1",
        "output": "735"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C[C@H]1CNC[C@@H](C)N1.Nc1c(F)c(F)cc2c1c(=O)c(C(=O)O)cn2C1CC1.c1ccncc1>>C[C@H]1CN(c2cc3c(c(N)c2F)c(=O)c(C(=O)O)cn3C2CC2)C[C@@H](C)N1",
        "output": "676"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.COc1ccc(C[C@@](C)(C#N)N[C@@H](C(N)=O)c2ccccc2)cc1.ClCCl.N.O=S(=O)(O)O>>COc1ccc(C[C@](C)(N[C@@H](C(N)=O)c2ccccc2)C(N)=O)cc1",
        "output": "8"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCNc1ccc(N)cc1-c1nc2cc(-c3ccccc3)ccc2o1.O=C(O)c1ccc2c(c1)C(=O)OC2=O>>CCCCNc1ccc(N2C(=O)c3ccc(C(=O)O)cc3C2=O)cc1-c1nc2cc(-c3ccccc3)ccc2o1",
        "output": "475"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.CCOc1c(C(C)n2nc(C(F)F)c3c(N)ncnc32)cc(Cl)c(F)c1C1CNC1.Cl.Cl>>CCOc1c(C(C)n2nc(C(F)F)c3c(N)ncnc32)cc(Cl)c(F)c1C1CN(C(C)C)C1",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=[N+]=[N-].O=C(O)C(CO)=NNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=NC1>>COC(=O)C(CO)=NNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=NC1",
        "output": "60"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCn1cc(C2(c3cccc(-c4cccnc4F)c3)N=C(N)N(C)C2=O)cc1C=O.CO.[BH4-].[Na+]>>CCn1cc(C2(c3cccc(-c4cccnc4F)c3)N=C(N)N(C)C2=O)cc1CO",
        "output": "745"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.Cl.ClCCl.O=C(NCCCC[C@H](NC(=O)C1CNCCO1)C(=O)c1nc2ccccc2s1)OCc1ccccc1>>CC(=O)N1CCOC(C(=O)N[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)c2nc3ccccc3s2)C1",
        "output": "125"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CC(=O)c1ccccc1.CO.O=C[O-].[Ir].[NH4+]>>CC(N)c1ccccc1",
        "output": "552"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl.O=C(NC1CCCNC1)c1ccc(Cl)cc1.O=C(O)c1cccc(-c2ccco2)c1>>O=C(NC1CCCN(C(=O)c2cccc(-c3ccco3)c2)C1)c1ccc(Cl)cc1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCP(=CC#N)(CCCC)CCCC.CCO.Cc1ccc(N(CC(C)C)S(=O)(=O)c2ccc(OCC3CCOCC3)cc2O)c(C)c1.Cc1ccccc1>>CCOc1cc(OCC2CCOCC2)ccc1S(=O)(=O)N(CC(C)C)c1ccc(C)cc1C",
        "output": "478"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Fc1cc(F)cc(C[C@@H]2CN(Cc3ccccc3)CCN2)c1.O=C(O)c1ncn([C@H]2CCCC[C@H]2O)c1-c1ccccc1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>O=C(c1ncn([C@H]2CCCC[C@H]2O)c1-c1ccccc1)N1CCN(Cc2ccccc2)C[C@H]1Cc1cc(F)cc(F)c1",
        "output": "729"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC(CCOc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1.CC(C)(C)OC(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1>>NC(CCOc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1",
        "output": "431"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)Cl.Cc1nnsc1CO.O>>CCOC(=O)OCc1snnc1C",
        "output": "144"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCC(=O)Cl.CCN(CC)CC.Cl.Nc1cnc2cc(F)ccc2c1O.O=C([O-])O.[Na+]>>CCCC(=O)Nc1cnc2cc(F)ccc2c1O",
        "output": "422"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOCC.COC(=O)c1ccc2c(c1)SCc1ccccc1C2=Cc1nnnn1C(c1ccccc1)(c1ccccc1)c1ccccc1.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>OCc1ccc2c(c1)SCc1ccccc1C2=Cc1nnnn1C(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "444"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.COc1cc(C#N)c(CCCO)c(C#N)c1O.ClCCl.O=S([O-])[O-].[Na+].[Na+]>>N#Cc1cc(O)c(O)c(C#N)c1CCCO",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)COC(=O)Cl.COc1cc(-c2cn(C3CCOCC3)c3ncnc(N)c23)ccc1N.ClCCl.c1ccncc1>>COc1cc(-c2cn(C3CCOCC3)c3ncnc(N)c23)ccc1NC(=O)OCC(C)(C)C",
        "output": "102"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC[C@H](N[C@@H](C)C(=O)O)C(=O)OCC.N>>CCC[C@H](N[C@@H](C)C(=O)O)C(N)=O",
        "output": "163"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)/C=C/c1ccc(Oc2c(-c3cccc(OC)c3)c(C)cc3cc(OC)ccc23)cc1.Cl.[Li+].[OH-]>>COc1cccc(-c2c(C)cc3cc(OC)ccc3c2Oc2ccc(/C=C/C(=O)O)cc2)c1",
        "output": "122"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cl.Nc1cc(C(=O)O)ccc1F.Oc1cccc2[nH]nnc12.[Cl-].[NH4+]>>NC(=O)c1ccc(F)c(N)c1",
        "output": "358"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccn(-c2ccc(OC[C@H]3COCC[C@@H]3NC(=O)OC(C)(C)C)cc2)n1.O=C1CCC(=O)N1Cl>>Cc1nn(-c2ccc(OC[C@H]3COCC[C@@H]3NC(=O)OC(C)(C)C)cc2)cc1Cl",
        "output": "856"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cl.N#Cc1ccc(OC(F)(F)F)cc1.NO>>N=C(NO)c1ccc(OC(F)(F)F)cc1",
        "output": "854"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC1(c2ccccc2C)CCc2c(CCl)cc3c(nc(C)n3C)c2O1.C[O-].[Na+]>>COCc1cc2c(nc(C)n2C)c2c1CCC(OC)(c1ccccc1C)O2",
        "output": "208"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(Cl)Cl.CCO.O=C(Cl)C(=O)Cl.O=C(O)c1cn(-c2cc([N+](=O)[O-])c(F)cc2F)c2cc(F)c(F)cc2c1=O>>CCOC(=O)c1cn(-c2cc([N+](=O)[O-])c(F)cc2F)c2cc(F)c(F)cc2c1=O",
        "output": "521"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNCC1.COc1ccc(C(=O)N2CCN(c3ccc([N+](=O)[O-])c(C=O)c3)CC2)cc1OC.O=C(O)CC(=O)O.c1ccncc1>>COc1ccc(C(=O)N2CCN(c3ccc([N+](=O)[O-])c(C=CC(=O)O)c3)CC2)cc1OC",
        "output": "12"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COc1ccccc1Oc1cc(Oc2cccnc2)cc(N)c1[N+](=O)[O-].[C].[H][H].[OH-].[OH-].[Pd+2]>>COc1ccccc1Oc1cc(Oc2cccnc2)cc(N)c1N",
        "output": "335"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN.CN1CCCC1=O.C[C@H]1COCCN1c1cc(C(C)(C)S(C)(=O)=O)nc(-c2cnc(NC(=O)Oc3ccccc3)s2)n1>>CNC(=O)Nc1ncc(-c2nc(N3CCOC[C@@H]3C)cc(C(C)(C)S(C)(=O)=O)n2)s1",
        "output": "488"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C/C(=C/C(=O)O)CCCCC(O)c1ccc2ccccc2c1.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCOCC.ClCCl.O=S([O-])O.[Na+]>>C/C(=C/C(=O)O)CCCCC(=O)c1ccc2ccccc2c1",
        "output": "32"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(C)=O.NC(=O)c1ccc2ccccc2c1.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>NCc1ccc2ccccc2c1",
        "output": "215"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(=O)c1c[nH]c2ccccc2c1=O.CN(C)C=O>>CCOC(=O)c1cn(C(=O)OC(C)(C)C)c2ccccc2c1=O",
        "output": "748"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COCCN.ClCCl.O=C1Cc2cc(S(=O)(=O)Cl)ccc2N1.c1ccncc1>>COCCNS(=O)(=O)c1ccc2c(c1)CC(=O)N2",
        "output": "43"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCCl.O=C(Cl)C(=O)Cl.O=C(O)CCc1ccc(N(CCCl)CCCl)cc1>>O=C(Cl)CCc1ccc(N(CCCl)CCCl)cc1",
        "output": "56"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3CC(C)C[C@@H]3[C@H]2CN)c1.Cc1cccc(C(=O)O)c1>>Cc1cccc(C(=O)NC[C@@H]2[C@H]3CC(C)C[C@H]3CN2C(=O)c2nc(C)sc2-c2cccc(C)c2)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCN(CC)CC.Cl.N#Cc1ccc(Cl)nn1.O=C1O[C@@H](CO)CN1c1ccc(N2CCNCC2)c(F)c1>>N#Cc1ccc(N2CCN(c3ccc(N4C[C@H](CO)OC4=O)cc3F)CC2)nn1",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)Cn1ccc2ccc(OCc3cc(-c4ccc(OC(F)(F)F)cc4)nn3C)cc21.[Li+].[OH-]>>Cn1nc(-c2ccc(OC(F)(F)F)cc2)cc1COc1ccc2ccn(CC(=O)O)c2c1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Cc1ccccc1-c1c(Cl)ccc2c1OC(CN=[N+]=[N-])C2.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1ccccc1-c1c(Cl)ccc2c1OC(CN)C2",
        "output": "89"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)[C@H]1CN(Cc2ccccc2)C[C@@H]1c1ccc(Cl)cc1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OC[C@H]1CN(Cc2ccccc2)C[C@@H]1c1ccc(Cl)cc1",
        "output": "343"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.CN(C)C=O.NCc1cc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)ccc1Br.O.c1ccncc1>>CC(=O)NCc1cc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)ccc1Br",
        "output": "206"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cl.O=c1cc(OCc2ccc(Cl)cc2)cnn1C1CCCCO1>>O=c1cc(OCc2ccc(Cl)cc2)cn[nH]1",
        "output": "689"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1CCNCC1.CCN=C=NCCCN(C)C.COC1=C(OC)C(=O)C(Cc2ccc(OCc3cccnc3)c(C(=O)O)c2)=C(C)C1=O.Cl.ClCCl>>COC1=C(OC)C(=O)C(Cc2ccc(OCc3cccnc3)c(C(=O)N3CCC(C)CC3)c2)=C(C)C1=O",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CN(C)Cc1ccc(-c2cccc(-n3c(=O)n([C@@H]4CC[C@H](NC(=O)OC(C)(C)C)CC4)c(=O)c4cc(F)cnc43)c2)cc1.Cl>>CN(C)Cc1ccc(-c2cccc(-n3c(=O)n([C@H]4CC[C@@H](N)CC4)c(=O)c4cc(F)cnc43)c2)cc1",
        "output": "538"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.COC(=O)C(NC(=O)OC(C)(C)C)c1ccc(C(=O)Nc2ccncc2)cc1.Cl.O.[Li+].[OH-]>>CC(C)(C)OC(=O)NC(C(=O)O)c1ccc(C(=O)Nc2ccncc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cncn1-c1cc(NC(=O)OC(C)(C)C)cc(C(F)(F)F)c1.Cc1nccn1-c1cc(NC(=O)OC(C)(C)C)cc(C(F)(F)F)c1>>Cc1cncn1-c1cc(N)cc(C(F)(F)F)c1",
        "output": "782"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)OB(c2ccc(S(=O)(=O)c3ccc(N)nc3)cc2)OC1(C)C.COCCOC.O.O=C([O-])[O-].OC(c1ccc(Cl)nc1)(C(F)(F)F)C(F)(F)F.[Cs+].[Cs+]>>Nc1ccc(S(=O)(=O)c2ccc(-c3ccc(C(O)(C(F)(F)F)C(F)(F)F)cn3)cc2)cn1",
        "output": "955"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O=C(O)c1cc(I)cc2c(O)ncnc12.O=S(=O)(O)O>>CCOC(=O)c1cc(I)cc2c(O)ncnc12",
        "output": "521"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)[C@@H]1CCC[C@H]1C(=O)OCC.O.[Li+].[OH-]>>CCOC(=O)[C@@H]1CCC[C@H]1C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CNc1cc2c(cc1F)C(=O)N(c1ccc([N+](=O)[O-])cc1)CO2.[Pd]>>CNc1cc2c(cc1F)C(=O)N(c1ccc(N)cc1)CO2",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)C12CCC(CO)(CC1)C2.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>COC(=O)C12CCC(C=O)(CC1)C2",
        "output": "142"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Cl)n3)c3ccccc23)n(-c2ccc(P(C)(C)=O)cc2)n1.Nc1ccc(SCCO)cc1>>CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(SCCO)cc4)n3)c3ccccc23)n(-c2ccc(P(C)(C)=O)cc2)n1",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.N#CCC(O)c1cccc(O)c1>>NCCC(O)c1cccc(O)c1",
        "output": "246"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O.COc1ccc(C(=O)CCC(=O)O)cc1.[C].[Pd]>>COc1ccc(CCCC(=O)O)cc1",
        "output": "92"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CN(C)C=O.COCCOC.CS(=O)(=O)Cc1nc(Cl)cc(Cl)n1.O.O=C([O-])[O-].OB(O)c1ccc2[nH]ccc2c1.[Na+].[Na+]>>CS(=O)(=O)Cc1nc(Cl)cc(-c2ccc3[nH]ccc3c2)n1",
        "output": "884"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cc1cc(N)ccc1F.II.O.O=C([O-])O.[Na+]>>Cc1cc(N)c(I)cc1F",
        "output": "372"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)c1c2c(cc3c(Cl)cccc13)CC1(COC(C)(C)OC1)C2.CC(C)Oc1cccc(OC(C)C)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.CCCCCC.CCOC(C)=O.CNC.C[Si](C)(C)[N-][Si](C)(C)C.[Li+]>>CC(=O)c1c2c(cc3c(N(C)C)cccc13)CC1(COC(C)(C)OC1)C2",
        "output": "105"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)CNc1ccc2oc3c(OC)ccc(C(=O)Nc4c(Cl)cncc4Cl)c3c2c1.CO.O.[K+].[OH-]>>COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2c1oc1ccc(NCC(=O)O)cc12",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClCCl.O=C1Nc2ncccc2[C@@]12Cc1cc3ccc(CO)nc3cc1C2.O=S(Cl)Cl>>O=C1Nc2ncccc2[C@@]12Cc1cc3ccc(CCl)nc3cc1C2",
        "output": "594"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1Cl.Cn1nc(COC2CCCCO2)cc1-c1cccc(C(=O)CC(=O)OC(C)(C)C)c1>>CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3cc(COC4CCCCO4)nn3C)c2)cc1Cl",
        "output": "929"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCC(C(=O)[O-])n1c(=NC(=O)c2ccc(C)cc2)sc2cc(OCc3ccccc3)ccc21.CO.[Na+].[OH-]>>CCC(C(=O)O)n1c(=NC(=O)c2ccc(C)cc2)sc2cc(OCc3ccccc3)ccc21",
        "output": "151"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CC(=O)O)Cc1cc(F)c(F)cc1F.CCC1NCCc2nccnc21.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.Cl.On1nnc2ccccc21>>CCC1c2nccnc2CCN1C(=O)C[C@@H](Cc1cc(F)c(F)cc1F)NC(=O)OC(C)(C)C",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCCCCCBr.CCCC[N+](CCCC)(CCCC)CCCC.CCCc1cc(S)ccc1C.Cc1ccccc1.O.[Br-].[Na+].[OH-]>>CCCc1cc(SCCCCCBr)ccc1C",
        "output": "124"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Clc1ccc(C2CCNC2)cc1.O=C(O)C(=O)O.O=C(O)c1cnoc1-c1ccccc1Cl>>O=C(c1cnoc1-c1ccccc1Cl)N1CCC(c2ccc(Cl)cc2)C1",
        "output": "975"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COc1ncccc1-n1ccc2c([N+](=O)[O-])cccc2c1=O.[Pd]>>COc1ncccc1-n1ccc2c(N)cccc2c1=O",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCO.CCOC(C)=O.Cc1cc(Br)cc(C)c1OCCO.O.O=C(O)c1ccc(B(O)O)cc1.[Cs+].[F-]>>Cc1cc(-c2ccc(C(=O)O)cc2)cc(C)c1OCCO",
        "output": "837"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C(Nc1ccccc1)c1csc(N2CC(O)C2)n1>>CS(=O)(=O)OC1CN(c2nc(C(=O)Nc3ccccc3)cs2)C1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)CC(=O)CC(=O)OCC.CCOCC.COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(=O)(=O)CCCCl)CC2)nc1N.NC(CCO)CCO.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(=O)(=O)CCCNC(CCO)CCO)CC2)nc1N",
        "output": "279"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COc1cc2nc(C)ccc2cc1C.ClCCl.O.O=S(=O)([O-])[O-].O=[Se]=O.[Mg+2]>>COc1cc2nc(C=O)ccc2cc1C",
        "output": "619"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.NCCO.O=C(Cl)c1cc([N+](=O)[O-])ccc1Cl.O=C([O-])O.[Na+]>>O=C(NCCO)c1cc([N+](=O)[O-])ccc1Cl",
        "output": "271"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#CC1CCCCCC1.O=C(NCCC(O)c1cccc(Br)c1)C(F)(F)F>>O=C(NCCC(O)c1cccc(C#CC2CCCCCC2)c1)C(F)(F)F",
        "output": "659"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(OC(=O)Cl)cc1.O=C(Nc1ccc(N2CCNCC2)nc1)c1nc(-c2ccccc2)oc1C(F)(F)F>>Cc1ccc(OC(=O)N2CCN(c3ccc(NC(=O)c4nc(-c5ccccc5)oc4C(F)(F)F)cn3)CC2)cc1",
        "output": "219"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1CC[C@H](O)C1.COC(=O)C(O)(c1cccs1)c1cccs1.Cc1ccccc1>>CN1CC[C@H](OC(=O)C(O)(c2cccs2)c2cccs2)C1",
        "output": "289"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)[C@H](Cc1ccc(OCCc2ccc(OS(C)(=O)=O)cc2)cc1)OCC.CCOC(C)=O.O.[Li+].[OH-]>>CCO[C@@H](Cc1ccc(OCCc2ccc(OS(C)(=O)=O)cc2)cc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CO.COC(=O)Cc1ccc(NC(=O)Nc2ccccn2)cc1.Cl.[Na+].[OH-]>>O=C(O)Cc1ccc(NC(=O)Nc2ccccn2)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOc1c(C)c(C)c(O)c(C=O)c1C.Cc1ccc(C(C)C)c(OCCN)c1.c1ccccc1>>CCOc1c(C)c(C)c(O)c(CNCCOc2cc(C)ccc2C(C)C)c1C",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)CCO.CCCN(CCC)CCC.CCn1ccc2nc(N3CCNCC3)ncc2c1=O.COc1cc2cnc(Cl)nc2cc1OC>>CCn1ccc2nc(N3CCN(c4ncc5cc(OC)c(OC)cc5n4)CC3)ncc2c1=O",
        "output": "36"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCOC(=O)C(F)(F)c1cnn(C)c(=O)c1.Cl.O>>Cn1ncc(C(F)(F)C(=O)O)cc1=O",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nc1ccccc1C(=O)c1ccncc1.Nc1cccnc1Cl>>Nc1cccnc1Nc1ccccc1C(=O)c1ccncc1",
        "output": "434"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cccc(-n2nc(C)cc2-c2ccnc(Cl)c2)c1.NCc1ccccc1>>Cc1cccc(-n2nc(C)cc2-c2ccnc(NCc3ccccc3)c2)c1",
        "output": "612"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1ccc2[nH]ccc2c1.CN(C)C=O.Cc1ccc(O)cc1.O.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(Oc2ccc3[nH]ccc3c2)cc1",
        "output": "238"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.CO.COc1cccc(N2CCNCC2)c1.ClC(Cl)Cl.O=C(n1ccnc1)n1ccnc1>>COc1cccc(N2CCN(C(=O)NCCCCN3CCN(c4cc(C(F)(F)F)nc(C(C)(C)C)n4)CC3)CC2)c1",
        "output": "734"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)=O.COc1ccc(I)cc1.O.O=C([O-])[O-].OB(O)c1cccc(O)c1.[K+].[K+].[Pd+2]>>COc1ccc(-c2cccc(O)c2)cc1",
        "output": "855"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.N#CBr.NC(=O)c1cnc(NC2CCCNC2)nc1Oc1ccc(Oc2ccccc2)cc1.O.O=C([O-])O.[Na+]>>N#CN1CCCC(Nc2ncc(C(N)=O)c(Oc3ccc(Oc4ccccc4)cc3)n2)C1",
        "output": "532"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Nc1ccc(O)cc1.O.O=[N+]([O-])c1cccnc1Cl>>O=[N+]([O-])c1cccnc1Nc1ccc(O)cc1",
        "output": "434"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cl.Nc1cc(-n2ccc(=O)cc2)c(Cl)cc1[N+](=O)[O-].O.[Fe]>>Nc1cc(Cl)c(-n2ccc(=O)cc2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)Cc1cnc([N+](=O)[O-])cc1C.[Pd]>>CCOC(=O)Cc1cnc(N)cc1C",
        "output": "457"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C.O.c1ccncc1>>CC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(C)=O)[C@@]4(C)CC(=O)[C@@H]32)C1",
        "output": "254"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(O)N1CCN(c2ccc(Nc3ncc4cccc(Br)c4n3)cc2)CC1.Cl[Pd]Cl.Nc1cccc(B(O)O)c1.O.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(O)N1CCN(c2ccc(Nc3ncc4cccc(-c5cccc(N)c5)c4n3)cc2)CC1",
        "output": "833"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccc(O)cc1.CN(C)C=O.O.O=C([O-])[O-].OCCOCCCl.[K+].[K+]>>CC(=O)c1ccc(OCCOCCO)cc1",
        "output": "74"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)N1CCc2c(c(N3CC(O[Si](C)(C)C(C)(C)C)Cc4cc(-c5cnn(C)c5)ccc43)nn2[C@H]2CCOC2)C1.CCCC[N+](CCCC)(CCCC)CCCC.O.[F-]>>CC(=O)N1CCc2c(c(N3CC(O)Cc4cc(-c5cnn(C)c5)ccc43)nn2[C@H]2CCOC2)C1",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CN1CCNCC1.O=C([O-])[O-].O=C1Nc2cccnc2N(C(=O)CCCCCl)c2ccccc21.[Na+].[Na+]>>CN1CCN(CCCCC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1",
        "output": "138"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)C1CC(=O)N(c2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)C1.[Na+].[OH-]>>COc1cc2nccc(Oc3ccc(N4CC(C(=O)O)CC4=O)cc3)c2cc1OC",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)c1cccc(CN2CN(C3CCCCC3)C3(CCNCC3)C2=O)c1.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].O=c1[nH]c2ccccc2n1CCCI.[K+].[K+]>>CC(C)(C)OC(=O)c1cccc(CN2CN(C3CCCCC3)C3(CCN(CCCn4c(=O)[nH]c5ccccc54)CC3)C2=O)c1",
        "output": "184"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CCCBr.CCOC(C)=O.CCc1c(B2OC(C)(C)C(C)(C)O2)cccc1C1CCNCC1.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CCCN1CCC(c2cccc(B3OC(C)(C)C(C)(C)O3)c2CC)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=[N+]([O-])c1cccc(-n2ccnc2)c1.[C].[Pd]>>Nc1cccc(-n2ccnc2)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CNCCN1.CCn1cc(C(=O)O)c(=O)c2cc(Cl)c(Cl)cc21.CS(C)=O>>CCn1cc(C(=O)O)c(=O)c2cc(Cl)c(N3CCNCC3)cc21",
        "output": "280"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COCCCCc1ccnc(C(=O)OC)c1.O.O.[Li+].[OH-]>>COCCCCc1ccnc(C(=O)O)c1",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1Br.O=c1[nH]c(Cl)ncc1F>>O=c1c(F)cnc(Cl)n1Cc1ccccc1Br",
        "output": "389"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N1CCNCC1.CN(C)c1ccncc1.O=S(=O)(Cl)c1cccc2ccccc12.c1ccncc1>>CC(=O)N1CCN(S(=O)(=O)c2cccc3ccccc23)CC1",
        "output": "99"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.C1COCCO1.CC(C)(C)[O-].CCOCC.CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1cc(CCc2cc(Br)cc(C#N)c2)nc(-n2c(C)ccc2C)c1.NCCc1ccccn1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1cc(CCc2cc(C#N)cc(NCCc3ccccn3)c2)nc(-n2c(C)ccc2C)c1",
        "output": "519"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.COc1cc(C2C(C#N)=C(N)Oc3c2ccc2c(N)cccc32)cc(Br)c1OC.O.c1ccncc1>>COc1cc(C2C(C#N)=C(N)Oc3c2ccc2c(NC(C)=O)cccc32)cc(Br)c1OC",
        "output": "6"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C(=O)O)c1ccccc1.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4CN)cc3)cc2)CC1.ClCCl.On1nnc2ccccc21>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4CNC(=O)C(C)(C)c4ccccc4)cc3)cc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1ccccn1.C#CCCc1nc2c(F)ccc(F)c2o1>>Fc1ccc(F)c2oc(CCC#Cc3ccccn3)nc12",
        "output": "777"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=[N+]([O-])c1ccc2c(c1)OC(CO)CO2.[Pd]>>Nc1ccc2c(c1)OC(CO)CO2",
        "output": "202"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cc(-c3ccc(-c4ccc(F)cc4)cc3)c(C(F)(F)F)nn2)CC1.ClCCl.O=C(O)C(F)(F)F>>Fc1ccc(-c2ccc(-c3cc(N4CCNCC4)nnc3C(F)(F)F)cc2)cc1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CC(C)(C)O.ClCCl.O=C1c2ccccc2C(=O)N1CCc1c[nH]c2ccc(Br)cc12>>CC(C)(O)C=Cc1ccc2[nH]cc(CCN3C(=O)c4ccccc4C3=O)c2c1",
        "output": "539"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1ncc(-c2cccc(NC(=O)OCc3ccccc3)c2C)c2c1[nH]c1cc(OC3CCOC3)ccc12.CO.O.O.[Li+].[OH-]>>Cc1c(NC(=O)OCc2ccccc2)cccc1-c1cnc(C(=O)O)c2[nH]c3cc(OC4CCOC4)ccc3c12",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCC[N+](CCC)(CCC)CCC.CCOC(=O)C1CCC(O)CC1.C[N+]1([O-])CCOCC1.O=[Ru](=O)(=O)[O-]>>CCOC(=O)C1CCC(=O)CC1",
        "output": "87"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc2ncc(C#N)c(Nc3ccc(Cl)cc3F)c2cc1OC.Cl.[NH4+].[OH-].c1ccncc1>>N#Cc1cnc2cc(O)c(O)cc2c1Nc1ccc(Cl)cc1F",
        "output": "19"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1ccc(Cl)nc1.Cn1nnc(-c2ccc(F)cc2)c1CO.O.[H-].[Na+]>>COC(=O)c1ccc(OCc2c(-c3ccc(F)cc3)nnn2C)nc1",
        "output": "433"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)[C@@H](Cc1cc(Cl)c(N)c(C(F)(F)F)c1)OC(=O)N1CCC(N2CCc3cc(OC)ccc3NC2=O)CC1.Cl.O.[Li+].[OH-]>>COc1ccc2c(c1)CCN(C1CCN(C(=O)O[C@H](Cc3cc(Cl)c(N)c(C(F)(F)F)c3)C(=O)O)CC1)C(=O)N2",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCc1ccc(C(=O)OC)cc1C(F)(F)F.Cl.[BH4-].[Li+]>>CCc1ccc(CO)cc1C(F)(F)F",
        "output": "444"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CNCCN(C)C.O=C(O)c1cc2c(Nc3cc4cn[nH]c4cn3)ncnc2[nH]1>>CN(C)CCN(C)C(=O)c1cc2c(Nc3cc4cn[nH]c4cn3)ncnc2[nH]1",
        "output": "605"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCN(c2cnc3ccc(-c4cncc(S(N)(=O)=O)c4)cc3n2)CC1.O=C(O)C(F)(F)F>>NS(=O)(=O)c1cncc(-c2ccc3ncc(N4CCNCC4)nc3c2)c1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=C(C)CC(O)(CCCl)c1ccccc1.CC#N.CC(C)(C)OC(=O)N1CCC[C@H](N)C1.O=C([O-])[O-].[K+].[K+]>>C=C(C)CC(O)(CCN[C@H]1CCCN(C(=O)OC(C)(C)C)C1)c1ccccc1",
        "output": "279"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)c1cccc(C(C)C)c1N=C=O.CCOC(C)=O.NC1COc2ccccc2C1>>CC(C)c1cccc(C(C)C)c1NC(=O)NC1COc2ccccc2C1",
        "output": "35"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.Cc1cc(C)c(S(=O)(=O)N2CC(C)(C)NC(=O)C2CC(=O)O)c(C)c1.ClCCCl.NC1CCCCCC1>>Cc1cc(C)c(S(=O)(=O)N2CC(C)(C)NC(=O)C2CC(=O)NC2CCCCCC2)c(C)c1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CO.CO.COC(=O)CC(N)c1ccccc1.COC(=O)CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1.ClCCl.NC(CC(=O)O)c1ccccc1.O.O=S(=O)(Cl)c1ccc2ccccc2c1.O=S(Cl)Cl.[Li+].[OH-]>>O=C(O)CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1",
        "output": "530"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc2c(OCCBr)cccc2n1.O=C(NC1CCCC1)c1cccc(CC2CCNCC2)c1>>Cc1ccc2c(OCCN3CCC(Cc4cccc(C(=O)NC5CCCC5)c4)CC3)cccc2n1",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCCl.ClCCl.O=C(O)CC(c1ccccc1)c1ccccc1.O=C1CNCCN1>>O=C1CN(C(=O)CC(c2ccccc2)c2ccccc2)CCN1",
        "output": "297"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1ccc(C(=O)O)cc1.COc1ccc(-c2cccs2)cc1C=O>>COc1ccc(-c2cccs2)cc1/C=C/C(=O)c1ccc(C(=O)O)cc1",
        "output": "656"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)N(CCCn1c(Sc2ncc(C(F)(F)F)cc2Cl)nc(C(N)=O)c1N)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CC(C)NCCCn1c(Sc2ncc(C(F)(F)F)cc2Cl)nc(C(N)=O)c1N",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(C)=O.COC(=O)c1cc([N+](=O)[O-])nn1-c1ccccc1.[Cl-].[Fe].[NH4+]>>COC(=O)c1cc(N)nn1-c1ccccc1",
        "output": "684"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(C(F)(F)F)cnc1Nc1ccc2c(ccn2Cc2ccccc2)c1.[Na+].[OH-]>>O=C(O)c1cc(C(F)(F)F)cnc1Nc1ccc2c(ccn2Cc2ccccc2)c1",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.Nc1cc2cccnc2c(Br)n1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].O=[N+]([O-])c1cccc(B(O)O)c1.[Na+].[Na+].[Pd]>>Nc1cc2cccnc2c(-c2cccc([N+](=O)[O-])c2)n1",
        "output": "876"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1.Cl>>N[C@@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "B.C1CCOC1.CC(=O)NCc1ccc(Cl)cc1.CSC.Cl>>CCNCc1ccc(Cl)cc1",
        "output": "533"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC=O.CO.Cl.NCc1ccc(N/C(=C2\\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1.[BH3-]C#N.[Na+]>>CCCNCc1ccc(N/C(=C2\\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1",
        "output": "627"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCCCCCCCN(C(=O)CCCCCCCCCCC)[C@]1(N)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1C(=O)CN.O=C(O)CNC(=O)CNC(=O)CNC(=O)OCc1ccccc1>>CCCCCCCCCCCCCCN(C(=O)CCCCCCCCCCC)[C@]1(N)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1C(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)OCc1ccccc1",
        "output": "645"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)N(C)C.CC(C)(C)OC(=O)C1CNC1.CCN(C(C)C)C(C)C.CCOC(=O)c1cnc(Cl)c(Cl)c1N>>CCOC(=O)c1cnc(N2CC(C(=O)OC(C)(C)C)C2)c(Cl)c1N",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)C=O.CNc1ccccc1.O=C(O)C1Cc2c([N+](=O)[O-])cc3[nH]c(=O)c(=O)[nH]c3c2C1.O=C(n1ccnc1)n1ccnc1>>CN(C(=O)C1Cc2c([N+](=O)[O-])cc3[nH]c(=O)c(=O)[nH]c3c2C1)c1ccccc1",
        "output": "315"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CC(N)(CO)CO.[H-].[Na+]>>CC(N)(CO)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C",
        "output": "602"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cc(Br)cnc1C1(O)CCC2(CC1)OCCO2.Cl.O=C([O-])O.[Na+]>>Cc1cc(Br)cnc1C1(O)CCC(=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C.CS(=O)(=O)Cl.Cn1ccnc1C=C[C@@H]1C[C@@H](O)CN1C(=O)OCc1ccccc1.O>>Cn1ccnc1C=C[C@@H]1C[C@@H](OS(C)(=O)=O)CN1C(=O)OCc1ccccc1",
        "output": "0"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1cc(F)cc(-c2nn(C(C)c3oc4ccccc4c(=O)c3-c3cccc(F)c3)c3ncnc(N)c23)c1.ClCCl>>CC(c1oc2ccccc2c(=O)c1-c1cccc(F)c1)n1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc21",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCc1cccc(Oc2cc(Cl)ccc2N(Cc2ccc(Cl)c(Cl)c2)C(=O)CCC(=O)O)c1.CCN(CC)CC.CCOP(=O)(C#N)OCC.CN(C)C=O.NCc1ccccc1F.O>>CC(C)(C)OC(=O)NCc1cccc(Oc2cc(Cl)ccc2N(Cc2ccc(Cl)c(Cl)c2)C(=O)CCC(=O)NCc2ccccc2F)c1",
        "output": "599"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc2c(ccc3nc(N)c(Cc4ccccc4)nc32)c1.Cl.O.c1cc[nH+]cc1>>Nc1nc2ccc3cc(O)ccc3c2nc1Cc1ccccc1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1c(-c2ccc(F)cc2)oc2cc(N)c(Br)cc12.ClCCl.O.O=S(=O)(Cl)c1ccccc1.c1ccncc1>>COC(=O)c1c(-c2ccc(F)cc2)oc2cc(NS(=O)(=O)c3ccccc3)c(Br)cc12",
        "output": "68"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Cl[Sn]Cl.O.O=[N+]([O-])c1ccc2nccc(Sc3ccc(Nc4nnc(-c5ccccc5)c5ccccc45)cc3)c2c1>>Nc1ccc2nccc(Sc3ccc(Nc4nnc(-c5ccccc5)c5ccccc45)cc3)c2c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.CCI.Cc1c(O)cccc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>CCOc1cccc([N+](=O)[O-])c1C",
        "output": "198"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#C[C@@H](CC(=O)OCC)c1ccc(O)cc1.COc1cnc(-c2csc3ccc(CCl)cc23)c(C)c1>>CC#C[C@@H](CC(=O)OCC)c1ccc(OCc2ccc3scc(-c4ncc(OC)cc4C)c3c2)cc1",
        "output": "49"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O=C(OCc1ccccc1)[C@]1(C(F)(F)F)CO1.O=[Pt].[H][H]>>O=C(O)[C@]1(C(F)(F)F)CO1",
        "output": "186"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc(-c2nnc3c4ccccc4c(Cl)nn23)no1.OCc1ccc(CO)nn1>>Cc1cc(-c2nnc3c4ccccc4c(OCc4ccc(CO)nn4)nn23)no1",
        "output": "407"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN.O=C1Nc2cc(C(=O)O)ccc2/C1=C(/Nc1ccc(CN2CCCCC2)cc1)c1ccccc1>>CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\\Nc1ccc(CN2CCCCC2)cc1)c1ccccc1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)Cc1sc(S)nc1C.Cl.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1nc(S)sc1CCO",
        "output": "225"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.CCO.CCOCC1COc2c(cc3ncc(C(=O)OCC)c(O)c3c2N)O1>>CCOCC1COc2c(cc3ncc(C(=O)OCC)c(O)c3c2NC(C)=O)O1",
        "output": "6"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NC1CCNC1.O=C(O)c1c2n(c3cc(Cl)c(F)cc3c1=O)CCS2.c1ccncc1>>CC(C)(C)OC(=O)NC1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)c2n3CCS2)C1",
        "output": "280"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ncc(CNc2ccc(-c3ccc(C#N)cc3)cc2F)c(CO)c1O.N#Cc1ccc(CBr)cc1>>Cc1ncc(CNc2ccc(-c3ccc(C#N)cc3)cc2F)c(CO)c1OCc1ccc(C#N)cc1",
        "output": "623"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)NC(C)C.CN(C)C=O.Fc1ccc(Cl)c(Br)c1.O.[Li]CCCC>>O=Cc1c(F)ccc(Cl)c1Br",
        "output": "239"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1cnc(N2CCC(NC(=O)c3[nH]c(C#N)c(Cl)c3Cl)CC2)s1.Cc1[nH]c(C(=O)NC2CCN(c3nc(O)c(C#N)s3)CC2)c(Cl)c1Cl>>N#Cc1[nH]c(C(=O)NC2CCN(c3ncc(C(=O)O)s3)CC2)c(Cl)c1Cl",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)c1cn(-c2ccc(F)cc2)c2c(F)c(N3CCC(n4ccnn4)C3)c(F)cc2c1=O.[Na+].[OH-]>>O=C(O)c1cn(-c2ccc(F)cc2)c2c(F)c(N3CCC(n4ccnn4)C3)c(F)cc2c1=O",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)[O-].CCCCCCC.Fc1ccccn1.O=C([O-])O.OCc1ccc(Br)cc1.[K+].[Na+]>>Brc1ccc(COc2ccccn2)cc1",
        "output": "541"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)C1=Cc2cc(Br)ccc2CCC1.[Na+].[OH-]>>O=C(O)C1=Cc2cc(Br)ccc2CCC1",
        "output": "58"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[Si](C)(C)OCc1cccc(B(O)O)c1.Cc1cc(Br)cc(CN2C(=O)c3ccccc3C2=O)c1.O=C([O-])[O-].[K+].[K+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(CN2C(=O)c3ccccc3C2=O)cc(-c2cccc(CO[Si](C)(C)C(C)(C)C)c2)c1",
        "output": "908"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NC1CCC(F)(F)CC1.ClCCl.O=C(O)C(F)(F)F>>NC1CCC(F)(F)CC1",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)CCCC(=O)C1.CCO.Cl.NO.O.O=C([O-])[O-].[Na+].[Na+]>>CC1(C)CCCC(=NO)C1",
        "output": "86"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COC(=O)c1ccc2[nH]c(C)c(Cc3ccc(-c4ccccc4)cc3Cl)c2c1.Cl.O.[Na+].[OH-]>>Cc1[nH]c2ccc(C(=O)O)cc2c1Cc1ccc(-c2ccccc2)cc1Cl",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CO1.CCOc1ccc(OCC2CO2)cc1.CNCc1c(C)nn(Cc2ccccc2Cl)c1C.CO>>CCOc1ccc(OCC(O)CN(C)Cc2c(C)nn(Cc3ccccc3Cl)c2C)cc1",
        "output": "76"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=[N+]=[N-].CC(=O)O.CC(C)C(C(N)=O)(c1ccccc1)N(C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1ccccc1)c1ccccc1.CCOCC>>COC(=O)CC[C@@H](NC(=O)Nc1ccccc1)C(=O)N(c1ccccc1)C(C(N)=O)(c1ccccc1)C(C)C",
        "output": "60"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CS(C)=O.Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2nc(Cl)n(CC3CC3)c2n1.NCCN1CCOCC1>>Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2nc(NCCN3CCOCC3)n(CC3CC3)c2n1",
        "output": "578"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O=C1CCCc2c1[nH]c1ccc(Cl)c(Cl)c21.O=Cc1ccccc1.[K+].[OH-]>>O=C1C(=Cc2ccccc2)CCc2c1[nH]c1ccc(Cl)c(Cl)c21",
        "output": "85"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCP(=CC#N)(CCCC)CCCC.CCO.CN1C(=O)Cc2c1ccc(-c1cccnc1)c2O.Cc1ccccc1.ClCCl.O.[Cl-].[Na+]>>CCOc1c(-c2cccnc2)ccc2c1CC(=O)N2C",
        "output": "478"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.O.[N-]=[N+]=NCCOCCOCCOc1cccc2cccnc12.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NCCOCCOCCOc1cccc2cccnc12",
        "output": "89"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)OC(=O)N1C[C@H](CO)N(C(=O)OCC2c3ccccc3-c3ccccc32)C2(CC2)C1.ClCCl>>CC(C)(C)OC(=O)N1C[C@H](C=O)N(C(=O)OCC2c3ccccc3-c3ccccc32)C2(CC2)C1",
        "output": "610"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C(=O)N2CC3CNCC3C2)c(OC)c1.Cc1cccc(Cl)n1>>COc1ccc(C(=O)N2CC3CN(c4cccc(C)n4)CC3C2)c(OC)c1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Clc1ccc2nc(Cl)ccc2c1.NC1CCCC(N)C1.c1ccncc1>>NC1CCCC(Nc2ccc3cc(Cl)ccc3n2)C1",
        "output": "70"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NCCNc1nc2ccccc2s1>>NCCNc1nc2ccccc2s1",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cccc(CBr)c1.NCc1ccccc1.Nc1nc(N)c2c(OCC3CCNCC3)cccc2n1>>Cc1cccc(CN2CCC(COc3cccc4nc(N)nc(N)c34)CC2)c1",
        "output": "248"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=C(C)CBr.CC(C)(N)CO.CN(C)C=O.[H-].[Na+]>>C=C(C)COCC(C)(C)N",
        "output": "120"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COc1ccc([N+](=O)[O-])c(C)c1.[Pd]>>COc1ccc(N)c(C)c1",
        "output": "202"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cc1cc([N+](=O)[O-])ccc1N1CCN(C(c2ccccc2)c2ncco2)CC1.[H][H].[Pd]>>Cc1cc(N)ccc1N1CCN(C(c2ccccc2)c2ncco2)CC1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1cc(O)c2cc([N+](=O)[O-])cc(OC)c2n1.COC(=O)c1cc(O)c2cccc([N+](=O)[O-])c2n1>>COC(=O)c1cc(O)c2cc(N)cc(OC)c2n1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN.COC(=O)C(C)Nc1nc(-c2ccc(F)c3ccccc23)cc(C(C)C)n1>>CNC(=O)C(C)Nc1nc(-c2ccc(F)c3ccccc23)cc(C(C)C)n1",
        "output": "392"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOc1cccc(-c2ccc3c(c2)NC(=O)C3)c1.COc1c(C(C)C)cc(C=O)cc1C(C)C>>CCOc1cccc(-c2ccc3c(c2)NC(=O)C3=Cc2cc(C(C)C)c(OC)c(C(C)C)c2)c1",
        "output": "439"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)c1ccc(C#N)cc1.CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].CN.[BH4-].[NH4+].[Na+].[OH-].[Ti+4]>>CNC(C)c1ccc(C#N)cc1",
        "output": "693"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1cc([N+](=O)[O-])ccc1F.[Pd]>>COC(=O)c1cc(N)ccc1F",
        "output": "481"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.ClCCl.O=S(=O)(Cl)Cl.O=S(=O)(Cl)c1cc(Cl)cc(Cl)c1O.c1ccncc1>>CC(=O)Oc1c(Cl)cc(Cl)cc1S(=O)(=O)Cl",
        "output": "111"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cn1c(Cl)nc2ccccc21.CN(C)C=O.O.Oc1ccc(-n2c3ncccc3n3ccnc23)cc1.[H-].[Na+]>>CC(=O)Cn1c(Oc2ccc(-n3c4ncccc4n4ccnc34)cc2)nc2ccccc21",
        "output": "542"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCP(CCCC)CCCC.CCOC(C)=O.COC(=O)C1=C(c2ccc(CCCO)cc2)C2(CC2)CN(C(=O)OC(C)(C)C)C1.Cc1ccccc1.Oc1c(F)ccc(F)c1Cl>>COC(=O)C1=C(c2ccc(CCCOc3c(F)ccc(F)c3Cl)cc2)C2(CC2)CN(C(=O)OC(C)(C)C)C1",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)OCC[C@@H]1C[C@@H]1C1CCN(c2ccc(C=O)cn2)CC1.CO.[BH4-].[Na+]>>CC(C)(C)[Si](C)(C)OCC[C@@H]1C[C@@H]1C1CCN(c2ccc(CO)cn2)CC1",
        "output": "476"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1Cc2ccc(O)cc2O1.CCC(C)=CCCC(C)=CCBr>>CCC(C)=CCCC(C)=CCOc1ccc2c(c1)OC(C)C2",
        "output": "77"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.CC(=O)O.O.c1ccc2c(c1)oc1ccccc12>>Brc1ccc2oc3ccccc3c2c1",
        "output": "98"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrP(Br)Br.CCc1cncc(Cl)c1CO.ClC(Cl)Cl>>CCc1cncc(Cl)c1CBr",
        "output": "300"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)Cc1cccc(-c2c(CO)cc3ccccn23)c1.O=[Mn]=O>>CN(C)Cc1cccc(-c2c(C=O)cc3ccccn23)c1",
        "output": "520"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)O.CCN(CC)CC.N[C@H]1CO[C@@H](CO)C1.Nc1c(Cl)ncnc1Cl>>Nc1c(Cl)ncnc1N[C@H]1CO[C@@H](CO)C1",
        "output": "166"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COc1c(C(C)=O)cc(Cl)c(Cl)c1I.[BH4-].[Na+]>>COc1c(C(C)O)cc(Cl)c(Cl)c1I",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)CC(=O)c1cccc(-n2nncc2COC2CCCCO2)c1.CC(C)N(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1C(F)(F)F>>CC(C)N(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-n3nncc3COC3CCCCO3)c2)cc1C(F)(F)F",
        "output": "929"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCC.CCOC(C)=O.COCCCCCCCCCCCC(=O)O>>COCCCCCCCCCCCCO",
        "output": "231"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.COCCOC.COc1cc(F)ccc1B(O)O.Cl[Pd]Cl.Clc1cc(Cl)ncn1.O=C([O-])[O-].[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1cc(F)ccc1-c1cc(Cl)ncn1",
        "output": "884"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)O.CC1(C)CCCC(C)(C)N1.CCOC(C)=O.CCOCC.CN(C)C=O.Fc1ccc2c(Cl)noc2c1F.[Li]CCCC>>O=Cc1cc2c(Cl)noc2c(F)c1F",
        "output": "239"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCc1nc(CO[Si](C)(C)C(C)(C)C)c(/C=C(\\Cc2cccs2)c2nnn[nH]2)n1Cc1ccccc1Cl.Cl>>CCCCc1nc(CO)c(/C=C(\\Cc2cccs2)c2nnn[nH]2)n1Cc1ccccc1Cl",
        "output": "708"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1cc(N2CCN(CCOc3ccccc3)C2=O)sc1C(=O)O.Cc1cc(N2CCN(Cc3ccc(F)cc3)C2=O)sc1C(=O)O.Cn1cc(CN)cn1>>Cc1cc(N2CCN(Cc3ccc(F)cc3)C2=O)sc1C(=O)NCc1cnn(C)c1",
        "output": "736"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCc1nc(C)c(C(O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCCc1nc(C)c(C(O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CNCC(C(=O)OC(C)(C)C)c1ccc([C@@H]2CC[C@@H](NC)CC2)cc1.O=C(Cl)c1ccc(Cl)cc1>>CNCC(C(=O)OC(C)(C)C)c1ccc([C@@H]2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)CC2)cc1",
        "output": "201"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.CCOC(=O)c1nc2ccc(Cl)cc2nc1O.O.[K+].[OH-]>>O=C(O)c1nc2ccc(Cl)cc2nc1O",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)N.O=C(O)c1ccc(Br)cc1F>>CC(C)NC(=O)c1ccc(Br)cc1F",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)CN.CCO.Nc1nc(Cl)cc(Cl)n1>>CC(C)CNc1cc(Cl)nc(N)n1",
        "output": "166"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COc1cc(Nc2ccc(N3CC(N4CCC(CO[Si](C)(C)C(C)(C)C)CC4)C3)cc2)c(NC(C)=O)cn1.O.[F-]>>COc1cc(Nc2ccc(N3CC(N4CCC(CO)CC4)C3)cc2)c(NC(C)=O)cn1",
        "output": "708"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1ccc2ncc(=O)n(CCN3CCC(N)CC3)c2c1.ClC(Cl)Cl.O=C([O-])O.O=Cc1nc2c(cc1Cl)SCC(=O)N2.[Na+].[Na+]>>COc1ccc2ncc(=O)n(CCN3CCC(NCc4nc5c(cc4Cl)SCC(=O)N5)CC3)c2c1",
        "output": "775"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.COc1ccc(F)c(F)c1CBr.Cl.O.O=[N+]([O-])c1cc(O)c(O)cc1Cl.[H-].[Na+]>>COc1ccc(F)c(F)c1COc1cc([N+](=O)[O-])c(Cl)cc1O",
        "output": "127"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COCC(=O)Cl.O=C(NCC1CNCCO1)c1c[nH]c2c(-c3c(OCC4CC4)ccc4c3OCO4)ncnc12>>COCC(=O)N1CCOC(CNC(=O)c2c[nH]c3c(-c4c(OCC5CC5)ccc5c4OCO5)ncnc23)C1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCNCC2)c1.C[C@@H](CCl)COc1ccc(Cl)cc1>>CC(C)C(=O)Nc1cccc(C2CCN(C[C@H](C)COc3ccc(Cl)cc3)CC2)c1",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCO)cs1.CC(C)OC(=O)[N+](=[N-])C(=O)OC(C)C.Oc1ccc(Br)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCOc2ccc(Br)cc2)cs1",
        "output": "478"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1c([C@@H](O)CN2CCC(N)CC2)ccc2c1COC2=O.Cl.N#Cc1ccc(C(=O)O)cn1>>Cc1c([C@@H](O)CN2CCC(NC(=O)c3ccc(C#N)nc3)CC2)ccc2c1COC2=O",
        "output": "674"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCC=O.NCc1cccc(Cl)c1>>CCCCNCc1cccc(Cl)c1",
        "output": "627"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cc1cc2cccc([N+](=O)[O-])c2[nH]1.NN.O.[Ni]>>Cc1cc2cccc(N)c2[nH]1",
        "output": "269"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=C(C)C(=O)Cl.CN(CCCCCCCCCCCO)c1ccc(N=Nc2ccc([N+](=O)[O-])cc2)cc1>>C=C(C)C(=O)OCCCCCCCCCCCN(C)c1ccc(N=Nc2ccc([N+](=O)[O-])cc2)cc1",
        "output": "320"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCCc1nc2cc(C(=O)OC)sc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1.O.O.[Li+].[OH-]>>CCCCc1nc2cc(C(=O)O)sc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].CCNc1ncccc1C(=O)Nc1c(C)cc(Cl)nc1Cl.O.[K+]>>CCNc1ncc(Br)cc1C(=O)Nc1c(C)cc(Cl)nc1Cl",
        "output": "292"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CNC.O=S(=O)(Cl)c1ccc(Br)cc1>>CN(C)S(=O)(=O)c1ccc(Br)cc1",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)CCC(C)(C)c2cc(-c3cc(N4CCNCC4)on3)ccc21.O=CCCCCO>>CC1(C)CCC(C)(C)c2cc(-c3cc(N4CCN(CCCCCO)CC4)on3)ccc21",
        "output": "484"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN.Cl.Clc1nc(Cl)nc(Cl)n1>>CNc1nc(Cl)nc(Cl)n1",
        "output": "578"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.ClCCl.Nc1c[nH]c2ncc(Br)c(F)c12.O.O.O=C(O)C1CCC1.O=C1OCCN1P(=O)(Cl)N1CCOC1=O.[Li]O>>O=C(Nc1c[nH]c2ncc(Br)c(F)c12)C1CCC1",
        "output": "724"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4nc(OCCN5C(=O)c6ccccc6C5=O)ccn4c3-c3ccccc3)cc2)CCC1.CO.Cl.ClCCl.[Na+].[OH-]>>NC1(c2ccc(-c3nc4nc(OCCN5C(=O)c6ccccc6C5=O)ccn4c3-c3ccccc3)cc2)CCC1",
        "output": "793"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)CCCCCCCOc1nc(-c2ccccc2)c(-c2ccccc2)n1-c1ccccc1.O.[Na+].[OH-]>>O=C(O)CCCCCCCOc1nc(-c2ccccc2)c(-c2ccccc2)n1-c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.Nc1cccc(Cl)c1.Nc1nc(-c2ccco2)c2nnn(CC(=O)O)c2n1.O.O=C(c1ncc[nH]1)c1ncc[nH]1>>Nc1nc(-c2ccco2)c2nnn(CC(=O)Nc3cccc(Cl)c3)c2n1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(S(=O)(=O)NCCc2cccc(OCC(=O)O)c2)cc1.NCc1ccccc1.O=C(O)CCCOc1cccc(CCNS(=O)(=O)c2ccc(Cl)cc2)c1.O=C(c1ncc[nH]1)c1ncc[nH]1.O=[N+]([O-])c1ccc(O)cc1>>Cc1ccc(S(=O)(=O)NCCc2cccc(OCC(=O)NCc3ccccc3)c2)cc1",
        "output": "599"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)COc1ccc(OCc2ncc(-c3ccccc3Cl)s2)cc1C.Cl.O.[Li+].[OH-]>>Cc1cc(OCc2ncc(-c3ccccc3Cl)s2)ccc1OCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C(=O)O)cc1/C=C/c1ccc(OC(F)(F)F)cc1.NC1CCCC1>>COc1ccc(C(=O)NC2CCCC2)cc1/C=C/c1ccc(OC(F)(F)F)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.Nc1cccc(Cl)n1.O=C1CCC(=O)N1Br>>Nc1ccc(Br)c(Cl)n1",
        "output": "518"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N(C)C.Nc1nc(Cl)cc(C(F)(F)F)n1.O.O=C(NCc1ccc(CO)cc1)C(F)(F)F.[H-].[Na+]>>Nc1nc(OCc2ccc(CNC(=O)C(F)(F)F)cc2)cc(C(F)(F)F)n1",
        "output": "461"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COc1ccc(OC)c(Br)c1.ClCCl.O.O=C(Cl)c1ccccc1.O=S(=O)(O)C(F)(F)F.[Na+].[OH-]>>COc1cc(C(=O)c2ccccc2)c(OC)cc1Br",
        "output": "61"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)c1cc(-c2ccccc2)c(-c2ccc(Cl)cc2)nc1OC.Cl.O.[Na+].[OH-]>>COc1nc(-c2ccc(Cl)cc2)c(-c2ccccc2)cc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.O.O=C(O)Cc1ccccc1I.Sc1ccccc1.[Cu].[K+].[OH-]>>O=C(O)Cc1ccccc1Sc1ccccc1",
        "output": "565"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=O)Cl.CCN(CC)CC.CCOCC.Oc1ccc(N=Nc2ccccc2)cc1>>CCC(=O)Oc1ccc(N=Nc2ccccc2)cc1",
        "output": "111"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc(-c2cc(CCl)ccn2)cc(OC)c1OC.NC(=O)C1CCNCC1>>COc1cc(-c2cc(CN3CCC(C(N)=O)CC3)ccn2)cc(OC)c1OC",
        "output": "156"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=C(CO)Nc1ccc2c(c1)CC(=O)N2.O=Cc1[nH]c2c(c1-c1ccc(F)cc1)C(=O)NCC2>>O=C(CO)Nc1ccc2c(c1)C(=Cc1[nH]c3c(c1-c1ccc(F)cc1)C(=O)NCC3)C(=O)N2",
        "output": "440"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cl[Sn]Cl.O.O.O=C([O-])O.O=[N+]([O-])c1ccc(-c2nc(C(F)(F)F)n[nH]2)cc1.[Na+]>>Nc1ccc(-c2nc(C(F)(F)F)n[nH]2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C(=O)O)n1cc(Cl)c(-c2cc(Cl)ccc2C#N)cc1=O.CC(C)(C)OC(=O)n1[nH]c(=O)cc1-c1ccc(N)cc1>>CC(C(=O)Nc1ccc(-c2cc(=O)[nH]n2C(=O)OC(C)(C)C)cc1)n1cc(Cl)c(-c2cc(Cl)ccc2C#N)cc1=O",
        "output": "365"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.CON(C)C(=O)c1cc2c(OC[C@@H](O)CN3CCC(c4ccc5ccccc5c4)CC3)cccc2o1.c1ccncc1>>CON(C)C(=O)c1cc2c(OC[C@H](CN3CCC(c4ccc5ccccc5c4)CC3)OC(C)=O)cccc2o1",
        "output": "254"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)c1ccccc1Nc1nc2ccc(C(=O)O)cc2[nH]1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COc1n[nH]c2cc(N)ccc12.F[P-](F)(F)(F)(F)F>>COc1n[nH]c2cc(NC(=O)c3ccc4nc(Nc5ccccc5C(C)C)[nH]c4c3)ccc12",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cc2c(cc1O)CCNC2.O=C(O)c1cc2ncc(Br)cn2n1>>COc1cc2c(cc1O)CCN(C(=O)c1cc3ncc(Br)cn3n1)C2",
        "output": "952"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cccc(C(=N)NN)n1.O=Cc1ccc(OCc2ccccc2)cc1O>>Cc1cccc(-c2n[nH]c(-c3ccc(OCc4ccccc4)cc3O)n2)n1",
        "output": "994"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.ClCC1CO1.O=Cc1cc(Br)ccc1O>>O=Cc1cc(Br)ccc1OCC(O)CCl",
        "output": "277"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-c2cc(C(F)(F)F)ccc2CNc2ccc(-c3ccc(Cl)cc3C)c(Cl)c2)cc1.[Na+].[OH-]>>Cc1cc(Cl)ccc1-c1ccc(NCc2ccc(C(F)(F)F)cc2-c2ccc(C(=O)O)cc2)cc1Cl",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCOC(C)=O.CS(C)=O.O.O=C(Cc1ccccc1)NC1C(=O)N2C(C(=O)O)C(CO)CS[C@H]12.O=[N+]([O-])c1ccc(CBr)cc1>>O=C(Cc1ccccc1)NC1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)C(CO)CS[C@H]12",
        "output": "403"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.CC(=O)Oc1ccc2cc(C)sc2c1.CCN(CC)CC.Cc1cc2ccc(O)cc2o1>>CC(=O)Oc1ccc2cc(C)oc2c1",
        "output": "111"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CN.CS(=O)(=O)OC[C@H](C[C@H]1CCCOC1)NC(=O)OCc1ccccc1>>CNC[C@H](C[C@H]1CCCOC1)NC(=O)OCc1ccccc1",
        "output": "559"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COc1ccc2c(c1)C(=O)C(C)(C)CC2.ClCCl.O.[BH4-].[Na+]>>COc1ccc2c(c1)C(O)C(C)(C)CC2",
        "output": "24"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)Cn1nc(-c2ccccc2O)nc1-c1ccccc1O.OCCNCCO>>O=C(Cn1nc(-c2ccccc2O)nc1-c1ccccc1O)N(CCO)CCO",
        "output": "494"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)[C@H](Cc1ccc(OC/C=C/c2cc(Br)cc(Br)c2)cc1)OCC.[Na+].[OH-]>>CCO[C@@H](Cc1ccc(OC/C=C/c2cc(Br)cc(Br)c2)cc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN.O=C(Nc1ccc(CNc2nc(Cl)nc3ccccc23)cc1)c1ccc(F)cc1>>CCNc1nc(NCc2ccc(NC(=O)c3ccc(F)cc3)cc2)c2ccccc2n1",
        "output": "544"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.O=C(Nc1ccc2c(c1)CCC2)c1cc([N+](=O)[O-])ccc1-c1cccs1.[Pd]>>Nc1ccc(-c2cccs2)c(C(=O)Nc2ccc3c(c2)CCC3)c1",
        "output": "489"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCCCC.COc1cc(Br)cc(OC)c1.COc1ccc(C=O)cc1F.O.[Li]CCCC>>COc1cc(OC)cc(C(O)c2ccc(OC)c(F)c2)c1",
        "output": "379"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCC(=O)NCc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccncc3)cc2)cc1.O=C(O)C(F)(F)F>>CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccncc3)cc2)n(-c2ccc(CNC(=O)CN)cc2)n1",
        "output": "431"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCCOc1ccccc1F>>COc1cc2ncnc(Oc3ccc(NC(=O)OCCOc4ccccc4F)cc3)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.CS(=O)(=O)OCCCc1ccc2c(c1)COC2=C1C(=O)Nc2ccc(F)cc21.O.OC1CCNCC1>>O=C1Nc2ccc(F)cc2C1=C1OCc2cc(CCCN3CCC(O)CC3)ccc21",
        "output": "496"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(c1c2c(nn1-c1ccc(Cl)cc1)CCC2)C1CCCCC1.CO.[Na+].[OH-]>>O=C(O)C(c1c2c(nn1-c1ccc(Cl)cc1)CCC2)C1CCCCC1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(O)cc2)CC1.CCC(C)=O.ClCCCBr.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(c2ccc(OCCCCl)cc2)CC1",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.CC1(C2CCCC2)Cc2cc(O)c(Cl)c(Cl)c2C1=O.N#CCCCCBr.O=C([O-])[O-].[K+].[K+]>>CC1(C2CCCC2)Cc2cc(OCCCCC#N)c(Cl)c(Cl)c2C1=O",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(=O)CCNC.CN(C)C=O.COc1ccc2oc(C(CCCCSC)Nc3ccc(C(=O)O)cc3)c(C)c2c1.Cl.O.On1nnc2ccccc21.[Cl-].[NH4+]>>CCOC(=O)CCN(C)C(=O)c1ccc(NC(CCCCSC)c2oc3ccc(OC)cc3c2C)cc1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#Cc1cccnc1.Cc1ccc(C(=O)O)cc1-n1cc(-c2ccc(Cl)nc2)nn1.Cc1ccc(C(=O)O)cc1N=[N+]=[N-]>>Cc1ccc(C(=O)O)cc1-n1cc(-c2cccnc2)nn1",
        "output": "40"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C[C@H](Cc1cccc(CO)c1)N(C[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(OC(=O)OC(C)(C)C)c2[nH]c(=O)ccc12)C(=O)OC(C)(C)C.ClCCl.[Mn+4].[O-2].[O-2]>>C[C@H](Cc1cccc(C=O)c1)N(C[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(OC(=O)OC(C)(C)C)c2[nH]c(=O)ccc12)C(=O)OC(C)(C)C",
        "output": "179"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.Nc1cccc(C(F)(F)F)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>O=C(Nc1cccc(C(F)(F)F)c1)C(F)(F)F",
        "output": "106"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(OCc1ccc([N+](=O)[O-])cc1)N1C[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1CO.[Cl-].[NH4+]>>O=C[C@@H]1C[C@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)CN1C(=O)OCc1ccc([N+](=O)[O-])cc1",
        "output": "610"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1ncn(CC(C)C)c1-c1ccccc1Br.CO.O.O=S(=O)([O-])O.[K+].[Na+].[OH-]>>CC(C)Cn1cnc(C(=O)O)c1-c1ccccc1Br",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC(CCC)COc1cccc(C[C@@H](O)CCl)c1.[N-]=[N+]=[N-].[Na+]>>CCCC(CCC)COc1cccc(C[C@@H](O)CN=[N+]=[N-])c1",
        "output": "243"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CC[O-].ClCCCCCBr.Oc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1.[Na+]>>ClCCCCCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1CC(=O)NN=C1c1ccc(NCC(C)(C)NC(=O)OCc2ccccc2)cc1.CO.[C].[H][H].[Pd]>>CC1CC(=O)NN=C1c1ccc(NCC(C)(C)N)cc1",
        "output": "574"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(N)CN.CCN(C(C)C)C(C)C.CCOC(=O)c1cnc(Cl)c(Cl)c1.CCOC(C)=O.CN1CCN(C)C1=O.O>>CCOC(=O)c1cnc(NCC(C)(C)N)c(Cl)c1",
        "output": "70"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(S(=O)(=O)N2CCN(C(C)c3ncc(Br)c(=O)[nH]3)CC2)cc1.O=P(Cl)(Cl)Cl>>COc1ccc(S(=O)(=O)N2CCN(C(C)c3ncc(Br)c(Cl)n3)CC2)cc1",
        "output": "14"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CNC.Cc1ccc(F)cc1S(=O)(=O)Cl>>Cc1ccc(F)cc1S(=O)(=O)N(C)C",
        "output": "99"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)O.CCO.Cl.O.O=[N+]([O-])c1cccc2c(Br)cccc12.[Fe]>>Nc1cccc2c(Br)cccc12",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ncc(Br)c(O)n1.O=P(Cl)(Cl)Cl>>Cc1ncc(Br)c(Cl)n1",
        "output": "25"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1ccc(-n2ncnn2)cc1.O=C(O)c1ccc(B(O)O)cc1.O=[N+]([O-])c1ccc(Cl)c(O)c1>>O=C(O)c1ccc(-c2ccc(-n3ncnn3)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)CCBr.CCO.Nc1ccc(O)cc1[N+](=O)[O-].O.[Li]O>>CC(C)CCOc1ccc(N)c([N+](=O)[O-])c1",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)N.O=Cc1ccc(-c2noc(-c3nnn(-c4ccccc4F)c3-c3ccncc3)n2)cc1>>CC(C)NCc1ccc(-c2noc(-c3nnn(-c4ccccc4F)c3-c3ccncc3)n2)cc1",
        "output": "468"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)C#N.CO.ClCCl.Clc1nc2ccccc2[nH]1.Clc1ncnc(Nc2cccc(Cn3ccnn3)c2)n1.O=C([O-])[O-].[K+].[K+]>>Clc1nc2ccccc2n1-c1ncnc(Nc2cccc(Cn3ccnn3)c2)n1",
        "output": "916"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)Nc1cc(F)c(C(=O)O)cc1[N+](=O)[O-].Cl>>Nc1cc(F)c(C(=O)O)cc1[N+](=O)[O-]",
        "output": "66"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)Nc1cc(N(Cc2cccc(Cl)c2)C(=O)C(F)(F)F)c(NC(=O)C(F)(F)F)cc1F.CO.Cl.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)Nc1cc(N(Cc2cccc(Cl)c2)C(=O)C(F)(F)F)c(N)cc1F",
        "output": "491"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CCC1CCCCN1S(=O)(=O)c1cc(C)c(Cl)cc1C.CO.O.[K+].[OH-]>>Cc1cc(S(=O)(=O)N2CCCCC2CCC(=O)O)c(C)cc1Cl",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCO.CN.ClCCl.Nc1ncc(Br)cc1C(=O)O.O=C(Cl)OC(Cl)(Cl)Cl>>CNC(=O)c1cc(Br)cnc1N",
        "output": "674"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N(CCCOc1cccc2oc(C(=O)O)c(CO)c12)C(C)(C)C.CI.CN(C)C=O.Cl.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1oc2cccc(OCCCN(C(=O)OC(C)(C)C)C(C)(C)C)c2c1CO",
        "output": "415"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Clc1nc(Cl)nc(Cl)n1.NC(=O)c1cnc2sccc2c1Cl>>N#Cc1cnc2sccc2c1Cl",
        "output": "624"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)C1CC(CO)CC1CC.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CCOC(=O)C1CC(C=O)CC1CC",
        "output": "142"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.O=CCCCc1ccccc1.Oc1ccc(SC2CCCNC2)cc1>>Oc1ccc(SC2CCCN(CCCCc3ccccc3)C2)cc1",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)[C@H](Cc1ccc(OCC=Cc2ccc3ccccc3n2)cc1)OCC.[Na+].[OH-]>>CCO[C@@H](Cc1ccc(OCC=Cc2ccc3ccccc3n2)cc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CCO.O=C(O)c1n[nH]cc1[N+](=O)[O-]>>CCOC(=O)c1n[nH]cc1[N+](=O)[O-]",
        "output": "47"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCCOCc1ccccc1.CN(C)C=O.Cc1ccccc1C1(O)CN(C(=O)OC(C)(C)C)C1.O.[H-].[Na+]>>Cc1ccccc1C1(OCCCCOCc2ccccc2)CN(C(=O)OC(C)(C)C)C1",
        "output": "95"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#CC(C)(C)O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ccc(Br)cc1.[Cu]I>>CC(C)(O)C#Cc1ccc(C=O)cc1",
        "output": "659"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.N#Cc1ccc(OCCCO)nc1.O.[Cl-].[Na+]>>CC(C)(C)[Si](C)(C)OCCCOc1ccc(C#N)cn1",
        "output": "193"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)c1ccc(I)c(Oc2ccc3ccccc3c2)c1.Cl.O.[BH4-].[Li+]>>OCc1ccc(I)c(Oc2ccc3ccccc3c2)c1",
        "output": "444"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Oc1ccc2c(c1)C(=O)C(Br)=C2c1ccccc1.CCOC(C)=O.CO.O=C([O-])[O-].[K+].[K+]>>O=C1C(Br)=C(c2ccccc2)c2ccc(O)cc21",
        "output": "22"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)Cc1nc(-c2cccc(C)c2)c(-c2ccnc(N)c2)s1.Cl.[Na+].[OH-]>>Cc1cccc(-c2nc(CC(=O)O)sc2-c2ccnc(N)c2)c1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CC(=O)NCc1nc(C(C)=O)cs1.CC(=O)O.O>>CC(=O)NCc1nc(C(=O)CBr)cs1",
        "output": "173"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N(C)C.CC(C)(C)OC(=O)N[C@@H](CC(=O)OCc1ccccc1)C(=O)O.CCN(C(C)C)C(C)C.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>CNC(=O)[C@H](CC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(/C=C/c2nc(-c3ccc(Cl)cc3Cl)cn2CC(=O)O)cc1.COc1ccc(CCN)cc1>>COc1ccc(/C=C/c2nc(-c3ccc(Cl)cc3Cl)cn2CC(=O)NCCc2ccc(OC)cc2)cc1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1CO.CCN(CC)CC.CCOCC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CC(C)(C)OC(=O)N1CCC[C@H]1C=O",
        "output": "610"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CN(C[C@@H]1CC[C@@H](CCO)CC1)C(=O)OCc1ccccc1.[Pd]>>CNC[C@@H]1CC[C@@H](CCO)CC1",
        "output": "428"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCn1c(=O)c2[nH]c(C34CCCC(CCC(=O)OC)(CC3)C4)nc2n(CCC)c1=O.[Na+].[OH-]>>CCCn1c(=O)c2[nH]c(C34CCCC(CCC(=O)O)(CC3)C4)nc2n(CCC)c1=O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)Cc1cc2ccc(F)cc2c(C2CCNCC2)c1C.COc1ccccc1N=C=O.ClCCl.O>>COC(=O)Cc1cc2ccc(F)cc2c(C2CCN(C(=O)Nc3ccccc3OC)CC2)c1C",
        "output": "323"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CN.O.O=[N+]([O-])c1cccc(Cl)c1F>>CNc1c(Cl)cccc1[N+](=O)[O-]",
        "output": "572"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CS(=O)(=O)c1ccc(-c2ncc3c(n2)C[C@@H](C2CCNCC2)O3)cc1>>CC(C)(C)OC(=O)N1CCC([C@@H]2Cc3nc(-c4ccc(S(C)(=O)=O)cc4)ncc3O2)CC1",
        "output": "694"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CCON=O.ClC(Cl)Cl.N#Cc1cc2c(cc1N)CCC2.[I-]>>N#Cc1cc2c(cc1I)CCC2",
        "output": "200"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCC.CCO.Nc1c(Cl)cc(C(F)(F)F)cc1[N+](=O)[O-].O=N[O-].O=S(=O)(O)O.[Na+]>>O=[N+]([O-])c1cc(Cl)cc(C(F)(F)F)c1",
        "output": "324"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C3(OC)CCN(C(=O)OC(C)(C)C)CC3)n(C)c2n1.ClCCl.O=C(O)C(F)(F)F>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C3(OC)CCNCC3)n(C)c2n1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)CNCCc1cn(C)c2c(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)cccc12.Cl.[Na+].[OH-]>>CC(C)Oc1ccc(-c2nc(-c3cccc4c(CCNCC(=O)O)cn(C)c34)no2)cc1Cl",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC[N+](CC)(CC)CC.O.O=P(Cl)(Cl)Cl.O=c1ccc2c([nH]1)CCN(Cc1ccccc1)C2.[Cl-]>>Clc1ccc2c(n1)CCN(Cc1ccccc1)C2",
        "output": "100"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CBr.CCCC[N+](CCCC)(CCCC)CCCC.CN1CN([C@@H]2CC[C@@H](O)CC2)CN(C)C1=O.Cc1ccccc1.O.O=S(=O)([O-])O.[Na+].[OH-]>>CN1CN([C@@H]2CC[C@@H](OCC(=O)OC(C)(C)C)CC2)CN(C)C1=O",
        "output": "669"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(C)c(S(=O)(=O)N2CCc3ccc(CO)cc3C2)c(C)c1.CS(=O)(=O)Cl.ClCCl>>COc1cc(C)c(S(=O)(=O)N2CCc3ccc(COS(C)(=O)=O)cc3C2)c(C)c1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.Cc1ccc2[nH]cc(/C=C/C(=O)O)c2c1.O>>Cc1ccc2c(c1)c(/C=C/C(=O)O)cn2C(=O)OC(C)(C)C",
        "output": "748"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1c(Cl)cccc1S(=O)(=O)Cl.Cc1noc2ccc(N)cc12.ClCCl.O=C([O-])O.[Na+].c1ccncc1>>Cc1c(Cl)cccc1S(=O)(=O)Nc1ccc2onc(C)c2c1",
        "output": "68"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Nc1cccc(B2OC(C)(C)C(C)(C)O2)c1.Oc1cccc(-c2ccc3c(Br)c(O)ccc3c2)c1>>CC(=O)Nc1cccc(-c2c(O)ccc3cc(-c4cccc(O)c4)ccc23)c1",
        "output": "933"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccccc1CN.O=[N+]([O-])c1ccc2nc(Cl)ccc2c1>>COc1ccccc1CNc1ccc2cc([N+](=O)[O-])ccc2n1",
        "output": "612"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.CCN(CC)CC.CCOC(=O)Cl.Cc1cccc(N)c1CO.ClCCl.O=C([O-])O.[Na+]>>Cc1cccc(NC(=O)CNC(=O)OC(C)(C)C)c1CO",
        "output": "365"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.Clc1cccc(Cl)c1N1CCNCC1.FC(F)(F)c1ccc2nc(Cl)[nH]c2c1.O>>FC(F)(F)c1ccc2nc(N3CCN(c4c(Cl)cccc4Cl)CC3)[nH]c2c1",
        "output": "36"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCOC(=O)N1C[C@H](OS(C)(=O)=O)C[C@H]1CO.CCN(CC)CC.ClCCl.O=S(=O)(Cl)c1ccc(Cl)cc1>>C=CCOC(=O)N1C[C@H](OS(C)(=O)=O)C[C@H]1COS(=O)(=O)c1ccc(Cl)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COS(=O)(=O)OC.COc1ccc(C(=O)O)c(O)c1.O=C(O)c1ccc(O)cc1O.O=P(Cl)(Cl)Cl.Oc1ccccc1>>COc1ccc(C(=O)Oc2ccccc2)c(O)c1",
        "output": "355"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=CC(=O)Cl.Nc1ccccc1>>C=CC(=O)Nc1ccccc1",
        "output": "10"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.O=C([O-])[O-].ON=Cc1ccccc1O.Oc1ccc(Br)c(F)c1.[Cs+].[Cs+].[Cu]I.c1cn[nH]c1>>Oc1ccc(-n2cccn2)c(F)c1",
        "output": "919"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)C(=O)Cl.CCN(CC)CC.ClCCl.Nc1ccncc1.O>>CC(C)(C)C(=O)Nc1ccncc1",
        "output": "9"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc(OC)c2c(=O)cc(-c3cc(C)ccc3Cl)oc2c1[C@@H]1CCN(C)[C@H]1CO.Cl.c1ccncc1>>Cc1ccc(Cl)c(-c2cc(=O)c3c(O)cc(O)c([C@@H]4CCN(C)[C@H]4CO)c3o2)c1",
        "output": "20"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCNCC(O)(CNc1cc(C)cc2c1cnn2-c1ccccc1)C(F)(F)F.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccccc1C(=O)O.F[P-](F)(F)(F)(F)F>>CCN(CC(O)(CNc1cc(C)cc2c1cnn2-c1ccccc1)C(F)(F)F)C(=O)c1ccccc1C",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CNCCNC.O=C1NCCC12CCC1(CC2)OCCO1.O=P([O-])([O-])[O-].OC(c1ccc(I)cc1)C(F)(F)F.[K+].[K+].[K+]>>O=C1N(c2ccc(C(O)C(F)(F)F)cc2)CCC12CCC1(CC2)OCCO1",
        "output": "921"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1c(Cl)c(C)c(C(C)=O)c(OCCBr)c1OCCCc1ccccc1.Cl.OC1CNC1>>COc1c(Cl)c(C)c(C(C)=O)c(OCCN2CC(O)C2)c1OCCCc1ccccc1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CN(C)C=O.CN(C)c1ccncc1.COC(=O)[C@@H]1[C@H](O)CCN1C(=O)OC(C)(C)C.c1c[nH]cn1>>COC(=O)[C@@H]1[C@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CCN1C(=O)OC(C)(C)C",
        "output": "602"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCc1nc2cc(Br)ccc2n1-c1ccc(CCO)cc1.CS(C)=O.ClCCl.Cl[Pd]Cl.O.[Fe+2].[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCc1nc2cc(B3OC(C)(C)C(C)(C)O3)ccc2n1-c1ccc(CCO)cc1",
        "output": "934"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCc1cc(C(=O)OCC)n(C)n1.Cl.O.[Na+].[OH-]>>CCCc1cc(C(=O)O)n(C)n1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cl.NO.O=C1CCN(Cc2ccccc2)CC1.c1ccncc1>>ON=C1CCN(Cc2ccccc2)CC1",
        "output": "86"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.CN(C)C=O.Cc1noc2nc(CC(C)C)[nH]c(=O)c12.O.O=C([O-])[O-].[K+].[K+]>>Cc1noc2nc(CC(C)C)n(Cc3ccccc3)c(=O)c12",
        "output": "389"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCC(CCC)C(=O)Cl.O=C(O)c1ccccc1O>>CCCC(CCC)C(=O)c1ccc(O)c(C(=O)O)c1",
        "output": "31"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOP(=O)(Cc1ccc(N)cc1)OCC.CS(=O)(=O)c1cccc(CN)c1.CS(=O)(=O)c1cccc(CNc2nc(Cl)ncc2C(F)(F)F)c1.CS(=O)(=O)c1cccc(CNc2ncc(C(F)(F)F)c(Cl)n2)c1.FC(F)(F)c1cnc(Cl)nc1Cl.O=C(O)C(F)(F)F>>CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(NCc3cccc(S(C)(=O)=O)c3)n2)cc1)OCC",
        "output": "808"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(C(=O)c2c(C)n(CCO)c3ccccc23)cc1.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>COc1ccc(C(=O)c2c(C)n(CCOS(=O)(=O)c3ccc(C)cc3)c3ccccc23)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(N)c1nccs1.O=C(O)c1ccc(C(F)(F)F)c(OCC2CC2)n1>>CC(C)(NC(=O)c1ccc(C(F)(F)F)c(OCC2CC2)n1)c1nccs1",
        "output": "137"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CCOc1ccc([N+](=O)[O-])cc1)C(=O)OC(C)(C)C.CCO.[Pd]>>CCN(CCOc1ccc(N)cc1)C(=O)OC(C)(C)C",
        "output": "202"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=O.CC#N.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NCC4CNCCO4)c4c3OCC4)nc2N1C1CCCC1.O.O=C([O-])O.[Na+].[Na+]>>CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NCC4CN(C)CCO4)c4c3OCC4)nc2N1C1CCCC1",
        "output": "217"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CCOC(=O)c1ccc2cc(Br)ccc2n1.CCOC(C)=O.O.O=P([O-])([O-])[O-].OB(O)c1ccc(O)cc1.[K+].[K+].[K+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1ccc2cc(-c3ccc(O)cc3)ccc2n1",
        "output": "837"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "O=C1CCc2ccc(O)cc2N1.O=S(=O)(CCCCBr)c1ccccc1>>O=C1CCc2ccc(OCCCCS(=O)(=O)c3ccccc3)cc2N1",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN1CC(N)(c2ccccc2)CCC1=O.O>>CN1CC(NC(=O)OC(C)(C)C)(c2ccccc2)CCC1=O",
        "output": "686"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C(=O)Cl.CN(C)C=O.C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)NC3CC3)cc2F)nc2c1CCNC2>>C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)NC3CC3)cc2F)nc2c1CCN(C(=O)N(C)C)C2",
        "output": "258"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClCCl.Nc1ccc2nc([C@H]3C[C@@H](N4CCCCC4)C3)sc2c1.O>>CC(=O)Nc1ccc2nc([C@H]3C[C@@H](N4CCCCC4)C3)sc2c1",
        "output": "9"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)C#N.CCN1CCOCC1.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COc1c(F)cc(CC(NC(=O)OC(C)(C)C)C(=O)O)cc1F.F[B-](F)(F)F.N#N.Nc1ccccc1N.O>>COc1c(F)cc(CC(NC(=O)OC(C)(C)C)c2nc3ccccc3[nH]2)cc1F",
        "output": "512"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCOC(=O)/C=C/c1cc(SCc2ccccc2)ccc1N.CCOC(C)=O.COC1CCCC1.COc1cc2ccccc2cc1Br.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>CCOC(=O)/C=C/c1cc(SCc2ccccc2)ccc1Nc1cc2ccccc2cc1OC",
        "output": "405"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrC(Br)(Br)Br.CN(C)C=O.COc1cc(OC)c2c(=O)[nH]c(-c3cc(C)c(CCCO)c(C)c3)nc2c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc(OC)c2c(=O)[nH]c(-c3cc(C)c(CCCBr)c(C)c3)nc2c1",
        "output": "378"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)N(C)C.CN(C)C=O.Cn1nccc1C(=O)O.Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)ccc1Cl.O=S(Cl)Cl>>Cn1nccc1C(=O)Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)ccc1Cl",
        "output": "844"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.COc1nnc(C(C)(F)F)cc1CO.CS(=O)(=O)Cl.ClCCl.O>>COc1nnc(C(C)(F)F)cc1COS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=O.O=CO.[Na+].[OH-].c1ccc2c(c1)C1CCNCC2C1>>CN1CCC2CC(C1)c1ccccc12",
        "output": "217"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc(C(C)C(O)(c2cccc3cnccc23)C(F)(F)F)c(Cl)c1.ClCCl.O=C([O-])O.[Na+]>>CC(c1ccc(O)cc1Cl)C(O)(c1cccc2cnccc12)C(F)(F)F",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COCCN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3cc(C)no3)c2)cc1Cl.ClCCl.O=C(O)C(F)(F)F>>COCCN(C)c1cc2c(cc1Cl)NC(=O)CC(c1cccc(-c3cc(C)no3)c1)=N2",
        "output": "930"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(CCCC(C)(C)C(=O)O)C(=O)O.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.OCc1ccccc1>>CC(C)(CCCC(C)(C)C(=O)OCc1ccccc1)C(=O)O",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC1(CC)OC(=O)N(CCC(C)(C)NCC(O)c2cc(OCc3ccccc3)cc3c2OCC(=O)N3)c2cc(F)ccc21.Cl>>CCC1(CC)OC(=O)N(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c2cc(F)ccc21",
        "output": "23"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OC)c1OC.ClB(Cl)Cl.ClCCl.O>>COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(O)c1OC",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NCCBr.CN(C)C=O.CSc1cc2c(cc1Sc1nc3c(N)nccc3[nH]1)OCO2.O=C([O-])[O-].[Cs+].[Cs+]>>CSc1cc2c(cc1Sc1nc3c(N)nccc3n1CCNC(=O)OC(C)(C)C)OCO2",
        "output": "276"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)c1c(NS(=O)(=O)c2ccc(F)cc2Br)ccc2c1[nH]c(=O)c1occc12.[I-].[Li+].c1ccncc1>>O=C(O)c1c(NS(=O)(=O)c2ccc(F)cc2Br)ccc2c1[nH]c(=O)c1occc12",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cccc(N=C=O)c1.c1ccc(CC2CCNCC2)cc1>>Cc1cccc(NC(=O)N2CCC(Cc3ccccc3)CC2)c1",
        "output": "323"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1ccc(CN)o1.Cc1nc(-n2ccc(OCc3ccccc3)cc2=O)sc1C(=O)O>>CCOC(=O)c1ccc(CNC(=O)c2sc(-n3ccc(OCc4ccccc4)cc3=O)nc2C)o1",
        "output": "534"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@@H](c2nc3ccccc3[nH]2)C1.CN(C)C=O.COCCCBr.[H-].[Na+]>>COCCCn1c([C@@H]2CCCN(C(=O)OC(C)(C)C)C2)nc2ccccc21",
        "output": "495"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(C)=O.CCn1cc(-c2ccc3c(c2)ncn3-c2cc(NC(C)=O)cc(-n3cccc3)c2)cn1.[Na+].[OH-]>>CCn1cc(-c2ccc3c(c2)ncn3-c2cc(N)cc(-n3cccc3)c2)cn1",
        "output": "66"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CNC.Clc1nccnc1-c1nc2ccccc2[nH]1>>CN(C)c1nccnc1-c1nc2ccccc2[nH]1",
        "output": "505"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cncc(B2OC(C)(C)C(C)(C)O2)c1.O=Cc1cccc(Br)c1>>COc1cncc(-c2cccc(C=O)c2)c1",
        "output": "954"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(C)=O.CN(C)Cc1c(OCC2CC2)ccc2c(CCC3CCNCC3)noc12.Cl.ClCCl.O=Cc1cccc2ccccc12.[Na+]>>CN(C)Cc1c(OCC2CC2)ccc2c(CCC3CCN(Cc4cccc5ccccc45)CC3)noc12",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cl.O=C(O)Cc1c(Cl)nc(-c2ccccc2)n1Cc1ccccc1>>CCOC(=O)Cc1c(Cl)nc(-c2ccccc2)n1Cc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc(C(=O)CN2C(=O)C(NC(=O)Nc3cccc(C(=O)OC(C)(C)C)c3)CN(C3CCCCC3)c3ccccc32)c(C)s1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(C(=O)CN2C(=O)C(NC(=O)Nc3cccc(C(=O)O)c3)CN(C3CCCCC3)c3ccccc32)c(C)s1",
        "output": "752"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC(O)c1cccc(Cl)c1>>CC(C)(C)OC(=O)NCC(O)c1cccc(Cl)c1",
        "output": "631"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCCc1ccccc1.CN(C)C=O.Cc1ccc2[nH]c3c(c2c1)CCN(C)CC3.I[Cu]I.O.O=C(O)[C@@H]1CCCN1.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)CC1",
        "output": "470"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N1CCC(C(=O)Cl)CC1.COc1cccc(OC)c1.S=C=S.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(C(=O)C2CCN(C(C)=O)CC2)c(OC)c1",
        "output": "31"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.Cc1cc(/C=C/C#N)cc(C)c1N.Cl.Clc1ccnc(Cl)n1.O>>Cc1cc(/C=C/C#N)cc(C)c1Nc1ccnc(Cl)n1",
        "output": "161"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCC(Br)C(=O)Cl.CCCCCCCCCCC[C@@H](O)CC(=O)OC.ClCCl.O.c1ccncc1>>CCCCCCCCCCC[C@H](CC(=O)OC)OC(=O)C(Br)CCCCCC",
        "output": "126"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1ccc(S(=O)(=O)n2cc(-c3c(C)nn(Cc4cccc(F)c4)c3C)c3cc(-c4cccc(N5CCNCC5)c4)cnc32)cc1.O=C([O-])[O-].OCCBr.[K+].[K+]>>Cc1ccc(S(=O)(=O)n2cc(-c3c(C)nn(Cc4cccc(F)c4)c3C)c3cc(-c4cccc(N5CCN(CCO)CC5)c4)cnc32)cc1",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1ccc(=O)n(CCCNC(=O)c2ccccn2)c1.O.O=C([O-])[O-].[Na+].[Na+]>>O=C(O)c1ccc(=O)n(CCCNC(=O)c2ccccn2)c1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C[C@@H]1COCCN1.O=C(O)c1[nH]c2ncnc(Nc3cc4cn[nH]c4cn3)c2c1Br>>C[C@@H]1COCCN1C(=O)c1[nH]c2ncnc(Nc3cc4cn[nH]c4cn3)c2c1Br",
        "output": "605"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NCC1CCCC(C(=O)O)C1.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1ccc2nccc(N)c2c1.F[P-](F)(F)(F)(F)F>>COc1ccc2nccc(NC(=O)C3CCCC(CNC(=O)OC(C)(C)C)C3)c2c1",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCC(C(=O)OCC)n1ccc(C(F)(F)F)n1.CCOC(=O)C(Br)C(C)C>>CCCCC(C(=O)O)n1ccc(C(F)(F)F)n1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.Cc1ccccc1.NCCOCCO.O.O=C([O-])[O-].O=[N+]([O-])c1ccccc1CS(=O)(=O)Cl.[K+].[K+]>>O=[N+]([O-])c1ccccc1CS(=O)(=O)NCCOCCO",
        "output": "493"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br.CC(=O)O.CCOC(=O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)n1.CCOCC.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2O)n1",
        "output": "23"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.Cc1cc(F)c(N)cc1[N+](=O)[O-].Cl.O.O=N[O-].[I-].[K+].[Na+]>>Cc1cc(F)c(I)cc1[N+](=O)[O-]",
        "output": "200"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCNc1cc(C(N)=O)cc(S(N)(=O)=O)c1Oc1ccccc1.CCCCOc1cc(C(=O)NCCCN2CCCCC2)cc(S(N)(=O)=O)c1Cc1ccccc1>>CCCCOc1cc(CNCCCN2CCCCC2)cc(S(N)(=O)=O)c1Cc1ccccc1",
        "output": "215"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cccc(-c2cc(Cl)nc(N)n2)c1C.NCc1cc(C2CC2)n[nH]1>>Cc1cccc(-c2cc(NCc3cc(C4CC4)n[nH]3)nc(N)n2)c1C",
        "output": "166"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC[Sn](Cl)(CCCC)CCCC.CCCCc1nc2n(c(=O)c1Cc1ccc(-c3ccccc3C#N)cc1)C(C)C(=O)N2.CN(C)C=O.Cc1ccccc1.[N-]=[N+]=[N-].[Na+]>>CCCCc1nc2n(c(=O)c1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(C)C(=O)N2",
        "output": "390"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N2CCNCC2)CC1.CCO.O=CC1CC1.[BH3-]C#N.[Na+]>>CC(C)(C)OC(=O)N1CCC(N2CCN(CC3CC3)CC2)CC1",
        "output": "484"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O=C1OCCN1CCO>>Cc1ccc(S(=O)(=O)OCCN2CCOC2=O)cc1",
        "output": "197"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCOC(C)=O.COCCOCCOCCN.COc1cc(N)cc(C(=O)O)c1.O=C([O-])O.[Na+]>>COCCOCCOCCNC(=O)c1cc(N)cc(OC)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)[O-].CNc1ccc(Cl)c(F)c1.O.O=C=O.[K+].[Li]CCCC>>CNc1ccc(Cl)c(F)c1C(=O)O",
        "output": "387"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C1OC(CCCO)CN1N=Cc1ccccc1.O=S(Cl)Cl.c1ccncc1>>O=C1OC(CCCCl)CN1N=Cc1ccccc1",
        "output": "96"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CO.Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCNCCCC(=O)OC(C)(C)C)c2cc1C.O=Cc1ccc(Cl)cc1.[BH3-]C#N.[Na+]>>Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCN(CCCC(=O)OC(C)(C)C)Cc3ccc(Cl)cc3)c2cc1C",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN1CC[NH+](C)C1Cl.COC1=C(OC)C(=O)C(Cc2ccc(OCc3cccnc3)c(C(=O)O)c2)=C(C)C1=O.ClCCl.Nc1cccnc1.[Cl-]>>COC1=C(OC)C(=O)C(Cc2ccc(OCc3cccnc3)c(C(=O)Nc3cccnc3)c2)=C(C)C1=O",
        "output": "759"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCN(C(C)C)C(C)C.Clc1cc(Cl)nc(N2CCOCC2)n1.NCCNc1ccccc1>>Clc1cc(NCCNc2ccccc2)nc(N2CCOCC2)n1",
        "output": "166"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CC[C@H]1C2=CC[C@@H](C(F)(F)F)[C@@H]1N.O=C=Nc1cccc(F)c1>>C[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CC[C@H]1C2=CC[C@@H](C(F)(F)F)[C@@H]1NC(=O)Nc1cccc(F)c1",
        "output": "35"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cc1[nH]c(=O)c(C#N)c(C)c1Br.Cl.[BH4-].[Na+]>>Cc1[nH]c(=O)c(CN)c(C)c1Br",
        "output": "560"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)OC[C@H](CON)O1.O=C(O)c1ccnc(Cl)c1Nc1ccc(I)cc1F>>CC1(C)OC[C@H](CONC(=O)c2ccnc(Cl)c2Nc2ccc(I)cc2F)O1",
        "output": "741"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#CCC[C@@H](O)CO[Si](C)(C)C(C)(C)C.CC(C)(C)[Si](C)(C)Cl.CCCCCCC.CCOC(C)=O.CN(C)C=O.COC(C)(C)C.c1c[nH]cn1>>C#CCC[C@H](CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCC([NH2+]C2CCCCC2)CC1.CC(C(=O)[O-])c1cc(C(F)(F)F)cc(C(F)(F)F)c1.CCOC(C)=O>>CC(C(=O)O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "151"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cccc(Cl)c1.ClCCl.O=C(Cl)c1ccc(Cl)cc1.O=C([O-])O.[Al+3].[Cl-].[Cl-].[Cl-].[Na+]>>COc1ccc(C(=O)c2ccc(Cl)cc2)c(Cl)c1",
        "output": "61"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.CCCCC.COC(=O)c1c(C)n(S(=O)(=O)c2ccccc2)c2ncc(Br)cc12.ClCCCl.O=C1CCC(=O)N1Br>>COC(=O)c1c(CBr)n(S(=O)(=O)c2ccccc2)c2ncc(Br)cc12",
        "output": "590"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.COCCl.ClCCl.O.Oc1cc(C(F)(F)F)ccc1F>>COCOc1cc(C(F)(F)F)ccc1F",
        "output": "375"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.COc1ccc(Cl)c(Nc2ncnc3cc(OCc4ccccc4)cc(OCCCN4CCCC4)c23)c1.[H][H].[Pd]>>COc1ccc(Cl)c(Nc2ncnc3cc(O)cc(OCCCN4CCCC4)c23)c1",
        "output": "23"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNC1.CCOC(C)=O.Cl.ClCCl.O=C1Cc2cc(S(=O)(=O)Cl)ccc2N1.c1ccncc1>>O=C1Cc2cc(S(=O)(=O)N3CCCC3)ccc2N1",
        "output": "99"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.Cl.Clc1nc(N2CCCCC2)nc2ccccc12.NCc1ccnc2ccccc12>>c1ccc2c(CNc3nc(N4CCCCC4)nc4ccccc34)ccnc2c1",
        "output": "110"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cl.O=C(Nc1cccc([N+](=O)[O-])c1)c1ccc(F)cc1Cl.[NH4+].[OH-]>>Nc1cccc(NC(=O)c2ccc(F)cc2Cl)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(C2=CCOc3ccccc32)cc1.O.O.[Li+].[OH-]>>O=C(O)c1ccc(C2=CCOc3ccccc32)cc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CN1C2CCC1CC(Sc1ccc([N+](=O)[O-])nc1)C2.Cl[Sn]Cl.O.O>>CN1C2CCC1CC(Sc1ccc(N)nc1)C2",
        "output": "457"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)CCn1c(-c2ccc(Cl)cc2N)c(C2CCCCC2)c2ccc(C(=O)OC)cc21.CO.Cl.O.[Na+].[OH-]>>COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccc(Cl)cc3N)n(CCC(=O)O)c2c1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cc1cc(Br)ccc1CO.ClCCl.O=S(Cl)Cl>>Cc1cc(Br)ccc1CCl",
        "output": "81"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1cccc(-c2nc(C(F)(F)F)ccc2CNC(=O)C(C)c2cccc(CN)c2)c1.ClCCl>>Cc1cccc(-c2nc(C(F)(F)F)ccc2CNC(=O)C(C)c2cccc(CNS(C)(=O)=O)c2)c1",
        "output": "742"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(C(C)C)C(C)C.Cc1ccc(-c2cc(CCC=O)nn2C(C)(C)C)cc1.Clc1ccc(N2CCNCC2)cc1Cl.[Na+]>>Cc1ccc(-c2cc(CCCN3CCN(c4ccc(Cl)c(Cl)c4)CC3)nn2C(C)(C)C)cc1",
        "output": "484"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "I.Nc1cc(Cl)c(Br)c(I)c1.Oc1ccccc1.[H][H]>>Nc1cc(Cl)cc(I)c1",
        "output": "350"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cc(C(=O)O)ccc1B(O)O.Cc1nnc(-c2ccc(Br)c(C)c2)o1>>Cc1nnc(-c2ccc(-c3ccc(C(=O)O)cc3C)c(C)c2)o1",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCI.CN(C)C=O.COc1cc2nccc(Oc3ccc(O)cc3C(C)=O)c2cc1OC.O=C([O-])[O-].[K+].[K+]>>CCCCOc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(C(C)=O)c1",
        "output": "198"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN1CCOCC1.CNC.ClCCCl.O=C(O)[C@@H]1COCC(=O)N1Cc1ccccc1.On1nnc2cccnc21>>CN(C)C(=O)[C@@H]1COCC(=O)N1Cc1ccccc1",
        "output": "685"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)CCc1ccc(OCc2sc(F)cc2-c2ccc(Cl)cc2)c(C)c1C.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1c(CCCO)ccc(OCc2sc(F)cc2-c2ccc(Cl)cc2)c1C",
        "output": "225"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.N[C@@H](CO)c1ccccc1.O.O=C(Cl)C1(Br)CC1.O=C([O-])[O-].[Na+].[Na+].[Na+].[OH-]>>O=C(N[C@@H](CO)c1ccccc1)C1(Br)CC1",
        "output": "206"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)CCCC(C)(C)N1.CCCCCO.c1ccc(Cc2cccc(OCC3CO3)c2)nc1>>CC1(C)CCCC(C)(C)N1CC(O)COc1cccc(Cc2ccccn2)c1",
        "output": "76"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.O=S(=O)(c1ccccc1)n1cc(CO)c(-c2ccccc2)c1-c1ccccc1.O=[Ru](=O)(=O)[O-]>>O=Cc1cn(S(=O)(=O)c2ccccc2)c(-c2ccccc2)c1-c1ccccc1",
        "output": "520"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCCN.CCN(CC)CC.O=C(O)C=Cc1ccccc1I.O=S(Cl)Cl>>CC(C)(C)OC(=O)NCCNC(=O)/C=C/c1ccccc1I",
        "output": "549"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(OCC)c1cc2cncc(-c3ccc(C(=O)O)cc3)c2o1.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.NCCO>>CCOC(OCC)c1cc2cncc(-c3ccc(C(=O)NCCO)cc3)c2o1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)O.CN(C)C=O.Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(=O)NCCC=O)c[nH]4)c3)cc2)c1.O.OC1CCNCC1.[BH3-]C#N.[Na+]>>Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(=O)NCCCN5CCC(O)CC5)c[nH]4)c3)cc2)c1",
        "output": "484"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(Cl)ccc1Oc1ccc(C#N)cc1-c1cccnc1OC.CS(C)=O.O=C([O-])[O-].OO.[K+].[K+]>>COc1cc(Cl)ccc1Oc1ccc(C(N)=O)cc1-c1cccnc1OC",
        "output": "180"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.O=CCc1ccc(OC(F)F)cc1.[BH4-].[Na+]>>OCCc1ccc(OC(F)F)cc1",
        "output": "223"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)O.CN=C=S.NCCOCc1c[nH]cn1>>CNC(=S)NCCOCc1c[nH]cn1",
        "output": "79"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1ccc(-n2cnnc2S)cc1.O.[Na+].[OH-]>>O=C(O)c1ccc(-n2cnnc2S)cc1",
        "output": "5"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1csc2nc(-c3cnccn3)nc(Cl)c12.NCCc1ccc2c(c1)OCO2>>Cc1csc2nc(-c3cnccn3)nc(NCCc3ccc4c(c3)OCO4)c12",
        "output": "723"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].Cc1cccc([N+](=O)[O-])c1Br.Cc1ccccc1.Nc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Cc1cccc([N+](=O)[O-])c1Nc1ccccc1",
        "output": "405"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)C1CN(Cc2ccc(-c3cc4cc(Cc5nccs5)ccc4o3)c(F)c2)C1.Cl.O.[Li+].[OH-]>>O=C(O)C1CN(Cc2ccc(-c3cc4cc(Cc5nccs5)ccc4o3)c(F)c2)C1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN.Cl.ClCCl.O.O=[N+]([O-])c1ccc(CCBr)cc1>>CNCCc1ccc([N+](=O)[O-])cc1",
        "output": "147"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NC1CCNCC1.CCN(CC)CC.ClCCl.Oc1ccccc1-c1nc(Cl)c2ccccc2n1>>CC(C)(C)OC(=O)NC1CCN(c2nc(-c3ccccc3O)nc3ccccc23)CC1",
        "output": "296"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C#N)c1ccc(Cl)nc1.COC(=O)c1ccnc(N)c1.COc1ccc(OC)c(P(C2CCCCC2)C2CCCCC2)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.COc1ccc(OC)c(P(C2CCCCC2)C2CCCCC2)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.Cl[Pd+].NCCc1[c-]cccc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccnc(Nc2ccc(C(C)(C)C#N)cn2)c1",
        "output": "606"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C/C(=N\\[Si](C)(C)C)O[Si](C)(C)C.CC(Cl)Cl.Fc1cccc(C(F)(F)F)c1CBr.O=c1[nH]cc(Br)c(=O)[nH]1>>O=c1[nH]c(=O)n(Cc2c(F)cccc2C(F)(F)F)cc1Br",
        "output": "389"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)c1ccc(O)c(C(C)(C)C)c1.CCN(CC)CC.CN(C)c1ccncc1.COC(=O)Cl.ClCCl.O>>COC(=O)Oc1ccc(C(C)(C)C)cc1C(C)(C)C",
        "output": "261"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc(C(=O)O)cc1-n1ccc2ccc(O)cc2c1=O.F[P-](F)(F)(F)(F)F.NC1CCC1.O>>Cc1ccc(C(=O)NC2CCC2)cc1-n1ccc2ccc(O)cc2c1=O",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.[Pd].c1ccc(COc2cc3nncn3cc2C2CC2)cc1>>Oc1cc2nncn2cc1C1CC1",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.COC(=O)/C=C/c1ccc2c(c1)C(=O)CC1(CCCN(Cc3ccccc3)CC1)O2.Cl>>O=C(O)/C=C/c1ccc2c(c1)C(=O)CC1(CCCN(Cc3ccccc3)CC1)O2",
        "output": "58"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cn(C)c2nc(OC)c(I)cc2c1=O.CO.Cl.[Na+].[OH-]>>COc1nc2c(cc1I)c(=O)c(C(=O)O)cn2C",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COc1cc(NC(=O)C(F)(F)F)c(C)cc1Cl.[Na+].[OH-]>>COc1cc(N)c(C)cc1Cl",
        "output": "491"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccccc1N.O=C(Cl)c1cccc(S(=O)(=O)Cl)c1>>COc1ccccc1NC(=O)c1cccc(S(=O)(=O)Cl)c1",
        "output": "11"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.COc1cc(OC)c(Cl)c(-c2ccc(C(=O)Nc3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cc3)c3nccnc23)c1Cl.Cl.ClCCl.O>>COc1cc(OC)c(Cl)c(-c2ccc(C(=O)Nc3ccc(N4CCNCC4)cc3)c3nccnc23)c1Cl",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCc1ccccc1Br.CC#N.CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C>>CC(C)(C)OC(=O)N1CCN(Cc2ccccc2Br)CC1",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCNC(=O)c1cc(Br)cc(C(=O)OC)c1.CO.O.[Li+].[OH-]>>CCNC(=O)c1cc(Br)cc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "FC(F)(F)c1ccc(-c2cc(CCl)on2)c(C(F)(F)F)c1.Fc1ccc(F)c(-c2nc3cn[nH]cc-3n2)c1>>Fc1ccc(F)c(-c2nc3cnn(Cc4cc(-c5ccc(C(F)(F)F)cc5C(F)(F)F)no4)cc-3n2)c1",
        "output": "997"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)N1CCNCC1.CC(C)(C)O.CC(C)(C)[O-].CCNc1ncc2c(n1)N1CCC[C@H]1CN(c1cncc(Br)c1)C2=O.CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CCNc1ncc2c(n1)N1CCC[C@H]1CN(c1cncc(N3CCN(C(C)=O)CC3)c1)C2=O",
        "output": "597"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=C(NC1(C(=O)OCc2ccccc2)CCCCC1)N1CCSC1.[Na+].[OH-]>>O=C(NC1(C(=O)O)CCCCC1)N1CCSC1",
        "output": "186"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCNc1cc2ncnc(N3CCN(C(=S)NCc4ccccc4)CC3)c2cc1N.ClCCl.O.O=C(Cl)c1ccccc1>>CCNc1cc2ncnc(N3CCN(C(=S)NCc4ccccc4)CC3)c2cc1NC(=O)c1ccccc1",
        "output": "11"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.CCCCCBr.O=C([O-])[O-].Oc1ccccc1.[K+].[K+]>>CCCCCOc1ccccc1",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CCN(C(=O)c2[nH]c(=O)n(C3CCCNC3)c2-c2ccccc2)CC1.ClCCl>>CC(=O)N1CCCC(n2c(-c3ccccc3)c(C(=O)N3CCN(C(=O)OC(C)(C)C)CC3)[nH]c2=O)C1",
        "output": "369"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.NCCN1CCC(Oc2ccc(F)c(F)c2)CC1.O=CC1CC1>>Fc1ccc(OC2CCN(CCNCC3CC3)CC2)cc1F",
        "output": "426"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COc1ccc(C(=O)NCc2cccc(C(=O)Nc3cnc4c(c3)CN(C(=O)OC(C)(C)C)CC4)c2)cc1OC.Cl.ClCCl>>COc1ccc(C(=O)NCc2cccc(C(=O)Nc3cnc4c(c3)CNCC4)c2)cc1OC",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.CN(C)CC1(c2ccc(O)cc2)CCOCC1.CO.COC1CCN(CCCCl)CC1.ClCCl.N.O=C([O-])[O-].[K+].[K+]>>COC1CCN(CCCOc2ccc(C3(CN(C)C)CCOCC3)cc2)CC1",
        "output": "74"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Nc1cccc(Oc2ccc([N+](=O)[O-])cn2)c1.CCO.[C].[Pd]>>CC(C)(C)OC(=O)Nc1cccc(Oc2ccc(N)cn2)c1",
        "output": "269"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1cc(C(F)(F)F)cnc1N[C@H]1CCC[C@@H]1N.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1ncccc1-c1ncccn1>>Cc1cc(C(F)(F)F)cnc1N[C@H]1CCC[C@@H]1NC(=O)c1ncccc1-c1ncccn1",
        "output": "137"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)[C@@H](N)CCSC.O=C(O)c1ccc(Oc2ccccn2)cc1-c1ccccc1>>COC(=O)[C@H](CCSC)NC(=O)c1ccc(Oc2ccccn2)cc1-c1ccccc1",
        "output": "652"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)c1ccc(NCC(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1.[K+].[OH-]>>O=C(O)c1ccc(NCC(c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1",
        "output": "5"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)c1ccccc1CN1CN(c2ccccc2)C2(CCN(C(=O)OCc3ccccc3)CC2)C1=O.CO.[Pd]>>CC(C)(C)OC(=O)c1ccccc1CN1CN(c2ccccc2)C2(CCNCC2)C1=O",
        "output": "428"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cl.ClCc1ccc(-n2ccnc2)cc1.O.O=C(O)CC1CCCc2c([nH]c3ccc(F)cc23)C1.[H-].[Na+]>>O=C(O)CC1CCCc2c(n(Cc3ccc(-n4ccnc4)cc3)c3ccc(F)cc23)C1",
        "output": "556"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc(C)nc(Cl)n1.Nc1cnc(-c2ccc(C3CCC3)c(O)c2F)cn1>>Cc1cc(C)nc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)n1",
        "output": "542"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(O)CCC(=O)c1cccc(O)c1.O=[N+]([O-])O>>O=C(O)CCC(=O)c1ccc([N+](=O)[O-])c(O)c1",
        "output": "21"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CC(C)=O.CCCCCCC(C)(C)c1ccc(C2CN(Cc3ccccc3)CCC2O)c(OCc2ccccc2)c1.O.O=S(=O)(O)O.[Cr+6].[NH4+].[O-2].[O-2].[O-2].[OH-]>>CCCCCCC(C)(C)c1ccc(C2CN(Cc3ccccc3)CCC2=O)c(OCc2ccccc2)c1",
        "output": "87"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.Cc1ccccc1.Fc1ccc(N2CCNCC2)cc1.O=S1(=O)c2cccc3cccc(c23)N1CCCCl>>O=S1(=O)c2cccc3cccc(c23)N1CCCN1CCN(c2ccc(F)cc2)CC1",
        "output": "138"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCS.CN(C)C=O.COc1ccc2ccn3cccc3c(=O)c2c1.Cl.[H-].[H][H].[Na+]>>O=c1c2cc(O)ccc2ccn2cccc12",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C[O-].O=[N+]([O-])c1ccc(F)c(-c2nc3cc(-c4ccccc4)ccc3o2)c1.[Na+]>>COc1ccc([N+](=O)[O-])cc1-c1nc2cc(-c3ccccc3)ccc2o1",
        "output": "485"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1nc(C)c2nc(-c3ccc(F)cc3)sc2c1O.CO.C[O-].NCC(=O)O.[Na+]>>Cc1nc(C(=O)NCC(=O)O)c(O)c2sc(-c3ccc(F)cc3)nc12",
        "output": "977"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(Cc3ccccc3)cc(C=O)c2c1.ClCCl.[Na+]>>Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(Cc3ccccc3)cc(CN3CCCC3)c2c1",
        "output": "757"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCc1cnc(-c2cnc(N3CCC(C(=O)OC)CC3)c([N+](=O)[O-])c2)o1.CO.[Na+].[OH-]>>CCc1cnc(-c2cnc(N3CCC(C(=O)O)CC3)c([N+](=O)[O-])c2)o1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCOC(C)=O.COC(=O)c1c(CC2CCN(Cc3cnc(-c4ccccn4)s3)CC2)c(=O)c2ccccc2n1CCCNC(=O)OCc1ccccc1.C[Si](C)(C)I>>COC(=O)c1c(CC2CCN(Cc3cnc(-c4ccccn4)s3)CC2)c(=O)c2ccccc2n1CCCN",
        "output": "574"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CCO.Cl.NO.O=Cc1ccc(C(F)(F)F)cc1.[Na+]>>ON=Cc1ccc(C(F)(F)F)cc1",
        "output": "30"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)C(=O)Cl.CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4O)no2)cc1C#N.ClCCl.c1ccncc1>>CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4OC(=O)C(C)(C)C)no2)cc1C#N",
        "output": "126"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(=O)C1CC12CCNCC2.ClCCCl.O=C1CCOCC1.[Na+]>>CCOC(=O)C1CC12CCN(C1CCOCC1)CC2",
        "output": "187"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCC[C@@H](CCO)Nc1nc(N)nc(C)c1CCCN.COC(=O)Cc1ccc(C=O)cc1.[Na+]>>CCCC[C@@H](CCO)Nc1nc(N)nc(C)c1CCCNCc1ccc(CC(=O)OC)cc1",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CCOc1ccc(N)cc1Cl.O=C(O)COc1ccc(-c2cccs2)cc1Cl>>CCN(CC)CCOc1ccc(NC(=O)COc2ccc(-c3cccs3)cc2Cl)cc1Cl",
        "output": "646"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1c(CO)ncnc1OC(F)F.ClCCl.O=S(Cl)Cl>>Cc1c(CCl)ncnc1OC(F)F",
        "output": "594"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.COC(=O)c1cc(CO)c(C)o1.Oc1ccc(-c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1cc(COc2ccc(-c3ccccc3)cc2)c(C)o1",
        "output": "550"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)CCCc1ccc(-c2nc(NC3CC(C)(C)NC(C)(C)C3)ncc2C)s1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1cnc(NC2CC(C)(C)NC(C)(C)C2)nc1-c1ccc(CCCCO)s1",
        "output": "343"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCC(CNC(=O)Cc2cc(F)cc(F)c2)(c2ccc(I)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(Cc1cc(F)cc(F)c1)NCC1(c2ccc(I)cc2)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc([N+](=O)[O-])ccc1N1CCN(C(=O)OC(C)(C)C)C(C)(C)C1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>COc1cc([N+](=O)[O-])ccc1N1CCNC(C)(C)C1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCC1CC1.O.O=C([O-])[O-].O=c1[nH]ccc2cc(Br)ccc12.[Cs+].[Cs+]>>O=c1c2ccc(Br)cc2ccn1CC1CC1",
        "output": "470"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=CCC(C)(C=O)c1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>C=CCC(C)(CO)c1ccccc1",
        "output": "223"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)n1nc(N)nc1-c1cn2c(n1)-c1ccc(Br)cc1OCC2.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccc(Cl)cc1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)n1nc(N)nc1-c1cn2c(n1)-c1ccc(-c3ccc(Cl)cc3)cc1OCC2",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.N#Cc1ccc(-c2cc(NCC3CCCCC3)nc(N)n2)cc1F.NN.O>>Nc1nc(NCC2CCCCC2)cc(-c2ccc3c(N)n[nH]c3c2)n1",
        "output": "945"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(Cl)Cl.CCOC(C)=O.Cn1nc(CO)c2c1C1CCC2CC1>>Cn1nc(C=O)c2c1C1CCC2CC1",
        "output": "573"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCOC(COc1ccc(N)cc1OC)OCC.CN(C)c1ccncc1.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(Cl)cc1[N+](=O)[O-]>>CCOC(COc1ccc(NC(=O)c2ccc(Cl)cc2[N+](=O)[O-])cc1OC)OCC",
        "output": "817"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.CC(C)(C)OC(=O)N1CCNCC1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)[C@@H]1CC[C@@H](Cn2c(=O)[nH]c3ccccc3c2=O)CC1>>CC(C)(C)OC(=O)N1CCN(C(=O)[C@@H]2CC[C@@H](Cn3c(=O)[nH]c4ccccc4c3=O)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)N1CCN(CCCCNC(C)=O)CC1.Cl.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)N1CCN(CCCCN)CC1",
        "output": "412"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CC[NH2+]CCCC(=O)NC1CC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cn1c2c(c3cc(C(=O)O)ccc31)CC(C1CCOCC1)CC2.F[P-](F)(F)(F)(F)F.[Cl-]>>CCN(CCCC(=O)NC1CC1)C(=O)c1ccc2c(c1)c1c(n2C)CCC(C2CCOCC2)C1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)NCC1CN(c2ccc(C3CCC(O)CC3)c(F)c2)C(=O)O1.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CC(=O)NCC1CN(c2ccc(C3CCC(=O)CC3)c(F)c2)C(=O)O1",
        "output": "87"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCC(=O)Nc1cc2c(cc1F)CC(=O)N2.Cc1c(C=O)[nH]c2c1C(=O)N(CCN1CCCCC1)CC2>>COCC(=O)Nc1cc2c(cc1F)C(=Cc1[nH]c3c(c1C)C(=O)N(CCN1CCCCC1)CC3)C(=O)N2",
        "output": "440"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)/C=C/c1ccc(N(C(=O)OC(C)(C)C)[C@@H]2CCN(CC3CCCC3)C2)nc1.Cl.[Na+].[OH-]>>CC(C)(C)OC(=O)N(c1ccc(/C=C/C(=O)O)cn1)[C@@H]1CCN(CC2CCCC2)C1",
        "output": "122"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.CCS(=O)(=O)Cl.Nc1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1>>CCS(=O)(=O)Nc1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1",
        "output": "194"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)CCCBr.CN(C)C=O.NC1CC1.O.[Cs+].[OH-]>>CCOC(=O)CCCNC1CC1",
        "output": "147"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.O=C(O)Cc1ccccc1I.O=S(=O)(O)O>>COC(=O)Cc1ccccc1I",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1nc2ccc(C(O)(c3ccc(C#N)cc3)c3cncn3C)cc2c(Cl)c1O.OCC1CC1>>COc1nc2ccc(C(O)(c3ccc(C#N)cc3)c3cncn3C)cc2c(Cl)c1OCC1CC1",
        "output": "547"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCc1nnnn1-c1cccc(C2Nc3ccc(C(=O)O)cc3CC2(C)C)c1.CN(C)C=O.NS(=O)(=O)C1CC1.O=C(n1ccnc1)n1ccnc1.[H-].[Na+]>>CCc1nnnn1-c1cccc(C2Nc3ccc(C(=O)NS(=O)(=O)C4CC4)cc3CC2(C)C)c1",
        "output": "580"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CNc1nc(Cl)nc2c1CCC2c1cc(F)c(F)c(F)c1.COc1cc(N)ccc1-n1cnc(Cl)n1>>CNc1nc(Nc2ccc(-n3cnc(Cl)n3)c(OC)c2)nc2c1CCC2c1cc(F)c(F)c(F)c1",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CC(=O)Cl.CCC1(C)CC(O)C(C)C(C)(CC)N1OC(C)c1ccccc1.CCN(CC)CC.Cc1ccccc1>>C=CC(=O)OC1CC(C)(CC)N(OC(C)c2ccccc2)C(C)(CC)C1C",
        "output": "320"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O.O=[N+]([O-])c1ccc(F)cc1.OCc1cccc(F)c1.[K+].[OH-]>>O=[N+]([O-])c1ccc(OCc2cccc(F)c2)cc1",
        "output": "485"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cnn(C5CCNCC5)c4)cnn23)c1.O=C(O)CC1CCCO1>>O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cnn(C5CCN(C(=O)CC6CCCO6)CC5)c4)cnn23)c1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCCCCBr.CC(C)=O.O=C(OCc1ccccc1)N1CCNCC1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CC(C)(C)OC(=O)NCCCCN1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCI.CN(C)C=O.Cc1ccccc1.O.O=Cc1ccc2[nH]c3cc(F)ccc3c2c1.[H-].[Na+]>>CCn1c2ccc(C=O)cc2c2ccc(F)cc21",
        "output": "302"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC1CCCN1.Cl.ClCCCOc1ccc(-c2nc(CN3CCCCC3)c(Br)o2)cc1.[I-].[Na+]>>CC1CCCN1CCCOc1ccc(-c2nc(CN3CCCCC3)c(Br)o2)cc1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cccc(C=O)c4)cc23)CC1.[Na+].c1csc(C2CCCN2)c1>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cccc(CN5CCCC5c5cccs5)c4)cc23)CC1",
        "output": "567"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC1(C)CC(=O)c2c(C(=O)Nc3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cn3)coc2C1.Cl.O=C([O-])[O-].[K+].[K+]>>CC1(C)CC(=O)c2c(C(=O)Nc3ccc(N4CCNCC4)cn3)coc2C1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)[C@@H](N)[C@@H](C)OC1(C)CCCC1.F[P-](F)(F)(F)(F)F.Nc1cc2ccccc2cc1C(=O)O>>COC(=O)[C@@H](NC(=O)c1cc2ccccc2cc1N)[C@@H](C)OC1(C)CCCC1",
        "output": "652"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrBr.CC(=O)c1cc(C)ccc1O.ClCCl.O.[Fe]>>CC(=O)c1cc(C)cc(Br)c1O",
        "output": "98"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C=CC[C@@H]1CCC2(C[C@H]1c1ccc(C(C)(C)CCCCCC)cc1OCc1ccccc1)OCCO2.CCOCC.O.O=S([O-])[O-].O=[Os](=O)(=O)=O.[Na+].[Na+].[Na+].[O-][I+3]([O-])([O-])[O-]>>CCCCCCC(C)(C)c1ccc([C@@H]2CC3(CC[C@H]2CC=O)OCCO3)c(OCc2ccccc2)c1",
        "output": "571"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.O.O=C1CCCc2ccc(N3CCCC3)cc21.[BH4-].[Na+]>>OC1CCCc2ccc(N3CCCC3)cc21",
        "output": "24"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.N=c1n(Cc2cccc3[nH]ccc23)c2ccccc2n1C1CCNCC1.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)cc1F.[Cs+].[Cs+]>>N=c1n(Cc2cccc3[nH]ccc23)c2ccccc2n1C1CCN(c2cc(Cl)ccc2[N+](=O)[O-])CC1",
        "output": "26"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1ccc(I)cc1.Cc1ccccc1.O=C([O-])[O-].OB(O)c1ccc2ccc3cccc4ccc1c2c34.[Na+].[Na+]>>Brc1ccc(-c2ccc3ccc4cccc5ccc2c3c45)cc1",
        "output": "855"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCOC(=O)CC1CCCn2c1cc1cc(OCc3cc(C#N)cc(OC(F)(F)F)c3)ccc12.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li+].[OH-]>>N#Cc1cc(COc2ccc3c(c2)cc2n3CCCC2CC(=O)O)cc(OC(F)(F)F)c1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1c(C=O)[nH]c2c1C(=O)N(CCN1CCCCC1)CC2.Cc1cccc2c1CC(=O)N2>>Cc1cccc2c1C(=Cc1[nH]c3c(c1C)C(=O)N(CCN1CCCCC1)CC3)C(=O)N2",
        "output": "440"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC[C@H](NC(=O)C1(NC(=O)N2CCOCC2)CCCCC1)C(O)C(=O)OCc1ccccc1.CO.[C].[Pd]>>CCCC[C@H](NC(=O)C1(NC(=O)N2CCOCC2)CCCCC1)C(O)C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CN(C)C=O.Cc1ccc(-c2ncccn2)c(C(=O)N2C[C@@H]3C[C@@H]3C[C@H]2CN)n1.Fc1cc(C(F)(F)F)cnc1F.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(-c2ncccn2)c(C(=O)N2C[C@@H]3C[C@@H]3C[C@H]2CNc2ncc(C(F)(F)F)cc2F)n1",
        "output": "810"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)NS(=O)(=O)c1ccc(-c2cn(-c3nc(-c4ccc(F)c(F)c4)cc(C(F)(F)F)n3)cn2)s1.ClCCl.O=C(O)C(F)(F)F>>NS(=O)(=O)c1ccc(-c2cn(-c3nc(-c4ccc(F)c(F)c4)cc(C(F)(F)F)n3)cn2)s1",
        "output": "680"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].CCOCC.COc1ccc(C(=O)O)c(OC)c1OC.[Na+]>>COc1c(Br)cc(C(=O)O)c(OC)c1OC",
        "output": "98"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.CCOC(C)=O.N#Cc1cc(Br)ccc1CBr.O=C([O-])[O-].Oc1ccc(Cl)c(Cl)c1.[K+].[K+]>>N#Cc1cc(Br)ccc1COc1ccc(Cl)c(Cl)c1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)C(=O)OCn1ccc2c(-c3cnn(C4CCCC4CO)c3)cnnc21.CN(C)c1ccncc1.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)C(=O)OCn1ccc2c(-c3cnn(C4CCCC4COS(C)(=O)=O)c3)cnnc21",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#C[Si](C)(C)C.C1CCNCC1.Ic1ccc(OCCN2CCCC2)cc1.[Cu]I>>C[Si](C)(C)C#Cc1ccc(OCCN2CCCC2)cc1",
        "output": "826"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN(C)CCCC(=O)O.COc1ccc(Oc2ccc(CNC(=O)C3(N)CC3)cc2)c(C(F)(F)F)c1.F[B-](F)(F)F>>COc1ccc(Oc2ccc(CNC(=O)C3(NC(=O)CCCN(C)C)CC3)cc2)c(C(F)(F)F)c1",
        "output": "133"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "N#CC1CCN(C(=O)N2CC(C(=O)O)CC(c3ccc(C(F)(F)F)cc3)C2)CC1.NC(=NO)c1cccc(Cl)c1>>N#CC1CCN(C(=O)N2CC(c3ccc(C(F)(F)F)cc3)CC(c3nc(-c4cccc(Cl)c4)no3)C2)CC1",
        "output": "926"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccccc1I.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>BrCc1ccccc1I",
        "output": "29"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "N#Cc1ccc(F)cc1.O=Cc1cccc(O)c1>>N#Cc1ccc(Oc2cccc(C=O)c2)cc1",
        "output": "564"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CC(C)(C)c1ccc(Br)cc1.CNCCCN(C)C.Cc1ccccc1.[Na+].[Pd+2]>>CN(C)CCCN(C)c1ccc(C(C)(C)C)cc1",
        "output": "294"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)C1OC(=O)Nc2ccc(OCCCCl)cc21.COc1ccc(S)cc1OC>>COc1ccc(SCCCOc2ccc3c(c2)C(C(C)C)OC(=O)N3)cc1OC",
        "output": "460"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.CI.CN(C)C=O.COc1cc(OC)cc(C(=O)c2ccc3cc[nH]c3c2)c1.[K+].[OH-]>>COc1cc(OC)cc(C(=O)c2ccc3ccn(C)c3c2)c1",
        "output": "191"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.NS(=O)(=O)Cc1ccc([N+](=O)[O-])cc1.O=[Pd]>>Nc1ccc(CS(N)(=O)=O)cc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(N=C=S)cc(OC)c1.Nc1ccc2[nH]cnc2c1>>COc1cc(NC(=S)Nc2ccc3[nH]cnc3c2)cc(OC)c1",
        "output": "474"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.N#CCC(=O)O.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1F)nn2[C@@H]1CCCNC1.O=C(n1ccnc1)n1ccnc1>>N#CCC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.NC1CCC1.O=C([O-])O.O=[N+]([O-])c1cc(C(F)(F)F)cnc1Cl.[Na+]>>O=[N+]([O-])c1cc(C(F)(F)F)cnc1NC1CCC1",
        "output": "70"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)[Si](OS(=O)(=O)C(F)(F)F)(C(C)C)C(C)C.CCN(CC)CC.ClCCl.OC[C@H]1CCN(c2nnc3ccc(F)cn23)C1>>CC(C)[Si](OC[C@H]1CCN(c2nnc3ccc(F)cn23)C1)(C(C)C)C(C)C",
        "output": "839"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCc1c(CNC)ccc2ccccc12.CN1CC(=O)Nc2ncc(/C=C/C(=O)O)cc2C1.CNCc1cn(C)c2ccccc12.Cl.Cl.O=C(O)/C=C/c1cnc2c(c1)CN(C(=O)OCc1ccccc1)CC(=O)N2>>CN(Cc1cn(C)c2ccccc12)C(=O)/C=C/c1cnc2c(c1)CN(C(=O)OCc1ccccc1)CC(=O)N2",
        "output": "811"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cc1ccc(S(=O)(=O)OCCCCCCCl)cc1.O=C([O-])[O-].Oc1ccc(-c2ccccc2)cc1.[K+].[K+]>>ClCCCCCCOc1ccc(-c2ccccc2)cc1",
        "output": "438"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1c(-c2ccc(OC)cc2)nc2[nH]nc(C)c2c1CCNC(=O)OCc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)c1c(-c2ccc(OC)cc2)nc2[nH]nc(C)c2c1CCN",
        "output": "574"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(C(C)(C)C)ccc1O.ClCC1CO1>>Cc1cc(C(C)(C)C)ccc1OCC1CO1",
        "output": "15"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Nc2nc(OCCN)nc3ccc(C(O)(c4ccc(Cl)cc4)c4ccc(Cl)cc4)cc23)CC1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)N1CCC(Nc2nc(OCCNS(C)(=O)=O)nc3ccc(C(O)(c4ccc(Cl)cc4)c4ccc(Cl)cc4)cc23)CC1",
        "output": "493"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)Cc1cccc(Nc2ncnc3oc(-c4ccccc4)c(-c4ccc(OC)cc4)c23)c1.NN.O>>COc1ccc(-c2c(-c3ccccc3)oc3ncnc(Nc4cccc(CC(=O)NN)c4)c23)cc1",
        "output": "130"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)[C@@](C)(CCn1cc(F)c(-c2cccc(Oc3nccs3)c2)cc1=O)S(C)(=O)=O.C[C@@](CCn1cc(F)c(-c2ccc(-n3nccn3)cc2)cc1=O)(C(=O)O)S(C)(=O)=O>>C[C@@](CCn1cc(F)c(-c2cccc(Oc3nccs3)c2)cc1=O)(C(=O)O)S(C)(=O)=O",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.Cl.NCCc1c[nH]cn1.O.O=C(O)c1cnc(-c2cccc(Cn3nc(-c4cc(F)c(F)c(F)c4)ccc3=O)c2)nc1.On1nnc2ccccc21>>O=C(NCCc1c[nH]cn1)c1cnc(-c2cccc(Cn3nc(-c4cc(F)c(F)c(F)c4)ccc3=O)c2)nc1",
        "output": "737"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CCc1cncnc1C(=O)O.Nc1cc(C(F)(F)F)cnc1O.O=C([O-])O.[Na+].c1ccncc1>>CCc1cncnc1C(=O)Nc1cc(C(F)(F)F)cnc1O",
        "output": "776"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cc1ccc(CBr)cc1.Cc1ccc(OCCc2ccc(CN3CCN(C(=O)/C=C/c4cc(C)c(Oc5ccc(O)cn5)c(Cl)c4)CC3)cc2)cc1.[H-].[Na+]>>Cc1ccc(COc2ccc(Oc3c(C)cc(/C=C/C(=O)N4CCN(Cc5ccc(CCOc6ccc(C)cc6)cc5)CC4)cc3Cl)nc2)cc1",
        "output": "623"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C1CCNCC1.CN(C)C=O.ClCCCl.O=C(O)C1(C(F)(F)F)CCCCC1.On1nnc2ccccc21.[Cl-].[NH4+]>>CCOC(=O)C1CCN(C(=O)C2(C(F)(F)F)CCCCC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)c1ccc2nnn(Cc3ccc(Cl)cc3Cl)c2c1.Cl.O.[Na+].[OH-]>>O=C(O)c1ccc2nnn(Cc3ccc(Cl)cc3Cl)c2c1",
        "output": "5"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCCCCCCCc1cnc(-c2ccc(C(=O)O)cc2)nc1.O=S(Cl)Cl>>CCCCCCCCCCCc1cnc(-c2ccc(C(=O)Cl)cc2)nc1",
        "output": "3"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Brc1cnc2[nH]c3cnc(-c4cccnc4)cc3c2c1.C1COCCO1.CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CN1CCNCC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[K+].[Pd].[Pd]>>CN1CCN(c2cnc3[nH]c4cnc(-c5cccnc5)cc4c3c2)CC1",
        "output": "597"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(=O)OC(C)(C)CCCCCBr.CCNCCCC(O)c1ccc(NS(C)(=O)=O)cc1.O=C([O-])O.[Na+]>>CCN(CCCCCC(C)(C)OC(C)=O)CCCC(O)c1ccc(NS(C)(=O)=O)cc1",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCCCCCCCCCCCCCNC(=O)OCC(CN)CC(C)OC(=O)c1ccccc1.CCCCCCCCCCCCCCCCSCC(CN=[N+]=[N-])CC(C)OC(=O)c1ccccc1.CO.[Pd]>>CCCCCCCCCCCCCCCCSCC(CN)CC(C)OC(=O)c1ccccc1",
        "output": "89"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1cc(C)c(CN)c(O)n1.ClCCl.F[P-](F)(F)(F)(F)F.N#Cc1c(Oc2ccc(C(=O)O)cc2Cl)cccc1-c1ccncn1.O>>Cc1cc(C)c(CNC(=O)c2ccc(Oc3cccc(-c4ccncn4)c3C#N)c(Cl)c2)c(O)n1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cccc(CN2C(=O)CCc3cc(-c4ccc(C(F)(F)F)cc4)ccc32)c1.CN(C)C=O.CO.[K+].[OH-]>>O=C(O)c1cccc(CN2C(=O)CCc3cc(-c4ccc(C(F)(F)F)cc4)ccc32)c1",
        "output": "5"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1=COCCC1.CCN(CC)CC.COC(=O)C1CC(O)CCN1C(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O>>COC(=O)C1CC(OC2CCCCO2)CCN1C(=O)OC(C)(C)C",
        "output": "141"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COc1cc(C(=O)O)ccn1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>COc1cc(CO)ccn1",
        "output": "72"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COc1ccc(C(C)=CBr)cc1.Cc1ccc2[nH]c3c(c2c1)CCN(C)CC3.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>COc1ccc(/C(C)=C/n2c3c(c4cc(C)ccc42)CCN(C)CC3)cc1",
        "output": "987"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1c(NCC2(NC(=O)OC(C)(C)C)CCCC2O[Si](C)(C)C(C)(C)C)ccc(C#N)c1Cl.O.[F-]>>Cc1c(NCC2(NC(=O)OC(C)(C)C)CCCC2O)ccc(C#N)c1Cl",
        "output": "708"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCOc1ccc(S(=O)(=O)Cl)cc1-c1nn2c(CCC)nc(C)c2c(=O)[nH]1.CO.ClCCl.OC1CCNCC1>>CCCOc1ccc(S(=O)(=O)N2CCC(O)CC2)cc1-c1nn2c(CCC)nc(C)c2c(=O)[nH]1",
        "output": "99"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCCC1C(=O)Nc1ccc(Br)cc1F.CCCC[N+](CCCC)(CCCC)CCCC.CSc1ccccc1B(O)O.Cc1ccccc1.O=C([O-])[O-].[Br-].[Na+].[Na+]>>CSc1ccccc1-c1ccc(NC(=O)C2CCCN2C(=O)OC(C)(C)C)c(F)c1",
        "output": "837"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N1CCNCC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.O.O=C([O-])O.O=Cc1cccc(Oc2ccccc2)c1.[Na+].[Na+]>>CC(=O)N1CCN(Cc2cccc(Oc3ccccc3)c2)CC1",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC.ClCCl.Fc1cccc(F)c1CBr.Nc1ncccc1O.O.[Cl-].[Na+].[OH-]>>Nc1ncccc1OCc1c(F)cccc1F",
        "output": "623"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.COC(=O)Cc1cccc(C(C)C)c1O.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCOc1c(CC(=O)OC)cccc1C(C)C",
        "output": "478"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCN(CCN)CC1.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)C=Cc1cccnc1>>CC(C)(C)OC(=O)N1CCN(CCNC(=O)C=Cc2cccnc2)CC1",
        "output": "549"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)[C@@H](N)Cc1ccc(NC(=O)c2c(Cl)cccc2Cl)cc1.Cl.[N-]=[N+]=NCCCCC1(C(=O)O)CCCC1>>COC(=O)[C@H](Cc1ccc(NC(=O)c2c(Cl)cccc2Cl)cc1)NC(=O)C1(CCCCN=[N+]=[N-])CCCC1",
        "output": "129"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.Cc1c(-c2cnn(C)c2)ccc2c1CCN2C(=O)OC(C)(C)C.Cl>>Cc1c(-c2cnn(C)c2)ccc2c1CCN2",
        "output": "830"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrC(Br)(Br)Br.CCOCC.OCCc1ccc(Cl)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Clc1ccc(CCBr)cc1",
        "output": "378"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCO.COC(=O)/C=C/c1cc(OC(C)C)nn1Cc1ncc(C(F)(F)F)cc1Cl.Cl.[Na+].[OH-]>>CC(C)Oc1cc(/C=C/C(=O)O)n(Cc2ncc(C(F)(F)F)cc2Cl)n1",
        "output": "58"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Clc1nc(Cl)c2cc(Br)ccc2n1.O.OCc1ccccc1.[H-].[Na+]>>Clc1nc(OCc2ccccc2)c2cc(Br)ccc2n1",
        "output": "461"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)Cl.COC(C)(C)C.O=C=O.OCC(F)(F)C(F)F.c1ccncc1>>CCOC(=O)OCC(F)(F)C(F)F",
        "output": "144"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN=C=NCCCN(C)C.Cl.ClCCl.Fc1ccccc1N1CCNCC1.Nc1onc(-c2ccccc2Cl)c1C(=O)O>>Nc1onc(-c2ccccc2Cl)c1C(=O)N1CCN(c2ccccc2F)CC1",
        "output": "975"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)c1nsc(N2CCC(N3CCC(Oc4ccc(Br)cc4F)C3=O)CC2)n1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCN(C(C)C)C(C)C.CCS.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]>>CCSc1ccc(OC2CCN(C3CCN(c4nc(C(C)C)ns4)CC3)C2=O)c(F)c1",
        "output": "824"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCC.CCN(CC)CC.ClC(Cl)Cl.Clc1cc(Cl)nc(Cl)n1.Nc1ccc(OC(F)(F)F)cc1>>FC(F)(F)Oc1ccc(Nc2nc(Cl)cc(Cl)n2)cc1",
        "output": "907"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CNC(=O)CCNCC(C)C.ClCCl.Clc1ncc(Br)c(Cl)n1>>CNC(=O)CCN(CC(C)C)c1nc(Cl)ncc1Br",
        "output": "296"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Nc1cc(-c2cc3ccccc3s2)c2[nH]ncc2c1.O=C1COc2ccc(S(=O)(=O)Cl)cc2N1>>O=C1COc2ccc(S(=O)(=O)Nc3cc(-c4cc5ccccc5s4)c4[nH]ncc4c3)cc2N1",
        "output": "68"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(CCc1ncc(-c2ccc([N+](=O)[O-])cc2)s1)C(=O)NS(=O)(=O)C(F)(F)F.Cc1nnc(CC2CCC(c3ncc(-c4ccc(N)cc4)s3)CC2)o1>>CC(C)(CCc1ncc(-c2ccc(N)cc2)s1)C(=O)NS(=O)(=O)C(F)(F)F",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CN=C=O.Cc1ccc(Cn2c(NC3CCN(CCN)CC3)nc3ccccc32)o1>>CNC(=O)NCCN1CCC(Nc2nc3ccccc3n2Cc2ccc(C)o2)CC1",
        "output": "244"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1nc(NC(C)=O)nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c12.ClCCl.O=C(O)C(F)(F)F>>COc1nc(NC(C)=O)nc2oc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)c12",
        "output": "793"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1nnn(C)c1-c1cnc2c3ccc(C(C)(C)N)c(F)c3n([C@H](c3ccccc3)C3CCOCC3)c2c1.ClCCl>>Cc1nnn(C)c1-c1cnc2c3ccc(C(C)(C)NS(C)(=O)=O)c(F)c3n([C@H](c3ccccc3)C3CCOCC3)c2c1",
        "output": "742"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCN.CCN=C=NCCCN(C)C.Cl.ClCCl.O=C(O)c1cccc(Cl)n1>>CCCCNC(=O)c1cccc(Cl)n1",
        "output": "137"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.ClCCl.O=S(=O)(c1ccccc1)c1ccc(O)cc1.c1ccncc1>>CC(=O)Oc1ccc(S(=O)(=O)c2ccccc2)cc1",
        "output": "111"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)c1cc2cnccc2s1.CCOC(C)=O.CN(C)C=O.COC(OC)N(C)C.O>>CN(C)/C=C/C(=O)c1cc2cnccc2s1",
        "output": "898"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(Cl)Cl.CCCCCCCCC(=O)Cl.Nc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1.c1ccncc1>>CCCCCCCCC(=O)Nc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1",
        "output": "9"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc(P(=O)(c2ccccc2)c2ccccc2)cc1.ClCCl>>O=P(c1ccccc1)(c1ccccc1)c1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CSc1cnc(N)c(I)c1.O=C([O-])O.O=S(=O)(Cl)c1ccccc1.[Na+].c1ccncc1>>CSc1cnc(NS(=O)(=O)c2ccccc2)c(I)c1",
        "output": "462"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN=C=NCCCN(C)C.CN1CCOCC1.Cc1cc(C(=O)O)ncc1C(Sc1ccc(C(F)(F)F)nc1)c1cc(F)ccc1F.Cl.ClCCl.NCCO.On1nnc2ccccc21>>Cc1cc(C(=O)NCCO)ncc1C(Sc1ccc(C(F)(F)F)nc1)c1cc(F)ccc1F",
        "output": "137"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)CN2CCC(c3ccc(Cl)cc3)(c3ccc(Cl)cc3)C2=O)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(CN1CCC(c2ccc(Cl)cc2)(c2ccc(Cl)cc2)C1=O)N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)Nc1ccncc1CCO.ClCCl.O=C(O)C(F)(F)F>>Nc1ccncc1CCO",
        "output": "782"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.Cl.Cl.ClCCl.O=C(Cl)CCl.O=C1O[C@@H](COc2ccon2)CN1c1ccc(N2CCNCC2)c(F)c1>>O=C(CCl)N1CCN(c2ccc(N3C[C@H](COc4ccon4)OC3=O)cc2F)CC1",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COc1ccc(Cn2c(=O)n([C@H]3CCNC3)c3ccc(C#N)cc32)cc1Cl.CS(=O)(=O)Cl.ClCCl.O>>COc1ccc(Cn2c(=O)n([C@H]3CCN(S(C)(=O)=O)C3)c3ccc(C#N)cc32)cc1Cl",
        "output": "584"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)C.CCN(CC)CC.COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(N)c4ccccc34)n2)cc(OC)n1.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Oc2ccccc2)cc1>>COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(C)cc4)c4ccccc34)n2)cc(OC)n1",
        "output": "965"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CCOC(=O)c1cn(CC)c2cc(N3CCNCC3)c(F)cc2c1=O.Cl>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)cc21",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC(=O)Cl.Cl.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-].c1ccc2c(c1)CCO2>>CCC(=O)c1ccc2c(c1)CCO2",
        "output": "31"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CCOc1ccccc1OCC1CO1.CC1CC(=O)NN=C1c1ccc(OCCN)cc1>>C=CCOc1ccccc1OCC(O)CNCCOc1ccc(C2=NNC(=O)CC2C)cc1",
        "output": "16"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Clc1nc2ccccc2[nH]1.Nc1cccc(C(F)(F)F)c1>>FC(F)(F)c1cccc(Nc2nc3ccccc3[nH]2)c1",
        "output": "808"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.Clc1ccnc(-n2ccnc2)n1.OCCC1CCCCN1>>OCCC1CCCCN1c1ccnc(-n2ccnc2)n1",
        "output": "162"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C.CCOC(C)=O.COc1cc([N+](=O)[O-])ccc1S(=O)(=O)NCCCCCC(=O)O>>COc1cc(N)ccc1S(=O)(=O)NCCCCCC(=O)O",
        "output": "401"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)c1cc(C2CC2)c(CO)cc1F.COC(=O)c1cc(Cl)c(CO)cc1F.Oc1cc(Cl)cc(Cl)c1.Oc1cnc(OCC(F)(F)C(F)F)c(Cl)c1>>CC(C)(C)OC(=O)c1cc(C2CC2)c(COc2cc(Cl)cc(Cl)c2)cc1F",
        "output": "550"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Cc1nnc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)s1.Cl.O.[Fe]>>Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1",
        "output": "401"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Nc1c([N+](=O)[O-])cccc1[N+](=O)[O-]>>Nc1cccc(N)c1N",
        "output": "204"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCOC(C)=O.CN(C)C=O.Cc1cc([N+](=O)[O-])cnc1Cl.O.O=C([O-])[O-].[K+].[K+]>>Cc1cc([N+](=O)[O-])cnc1N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)[O-].CO.Cl.NO.O=C1CC(CCCN2CCN(c3ccc(F)cc3)CC2)S(=O)(=O)c2ccccc21.[Na+]>>O=S1(=O)c2ccccc2C(=NO)CC1CCCN1CCN(c2ccc(F)cc2)CC1",
        "output": "212"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCCCO.CCN(C(C)C)C(C)C.CN(C)c1ccncc1.ClCCCl.ClCCl.O=C(O)CCCCCCC(=O)O>>CCCCCCCCCOC(=O)CCCCCCC(=O)O",
        "output": "47"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Nc1ccc2nc(-c3ccc(C4CCCCC4)cc3)cc(N)c2c1.Cl.[Na+].[OH-]>>Nc1ccc2nc(-c3ccc(C4CCCCC4)cc3)cc(N)c2c1",
        "output": "66"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrBr.ClC(Cl)(Cl)Cl.O=S([O-])([O-])=S.[Na+].[Na+].c1ccc(-c2ccc(-c3c4ccccc4cc4ccccc34)cc2)cc1>>Brc1c2ccccc2c(-c2ccc(-c3ccccc3)cc2)c2ccccc12",
        "output": "98"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CCOCC.ClCCl.O=[Cr](=O)([O-])Cl.OCC(F)=CC(F)(F)F.[Na+].c1cc[nH+]cc1>>O=C/C(F)=C/C(F)(F)F",
        "output": "183"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1nc2cnc(Nc3ccnc(NCC(F)(F)C(=O)O)n3)cc2n1C(C)C.F[P-](F)(F)(F)(F)F.[Cl-].[NH4+]>>Cc1nc2cnc(Nc3ccnc(NCC(F)(F)C(N)=O)n3)cc2n1C(C)C",
        "output": "313"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.Cc1c(C)c2c(c(C)c1O)CCC(C)(C#Cc1csc3ccccc13)O2.c1ccncc1>>CC(=O)Oc1c(C)c(C)c2c(c1C)CCC(C)(C#Cc1csc3ccccc13)O2",
        "output": "46"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCCC1=O.COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c2cc(C3CC3)nn12.O=[W](=O)(O)O.OO.[Mn+4].[O-2].[O-2]>>COc1ccc(C(=O)Cc2c(Cl)c[n+]([O-])cc2Cl)c2cc(C3CC3)nn12",
        "output": "396"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COCCCN.O=C(O)c1ccc(C(=O)Nc2ccc(Cl)c(-c3ccccn3)c2)c(Cl)c1>>COCCCNC(=O)c1ccc(C(=O)Nc2ccc(Cl)c(-c3ccccn3)c2)c(Cl)c1",
        "output": "902"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CN1CCN(Cc2ccc(-c3cc4nccc(Oc5ccc([N+](=O)[O-])cc5F)c4s3)nc2)CC1.O.[Cl-].[Fe].[NH4+]>>CN1CCN(Cc2ccc(-c3cc4nccc(Oc5ccc(N)cc5F)c4s3)nc2)CC1",
        "output": "335"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCc1[nH]n(C2CCCC2)c2nc(-c3cc(C)nc(Cl)c3)nc(=O)c1-2.CN(C)C=O.[Pd]>>CCc1[nH]n(C2CCCC2)c2nc(-c3ccnc(C)c3)nc(=O)c1-2",
        "output": "40"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cl.NO.O.O=Cc1cc(Br)ccc1OC(F)(F)F>>ON=Cc1cc(Br)ccc1OC(F)(F)F",
        "output": "30"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COC(=O)c1nc(-c2ccco2)cc(SC)c1OCc1ccccc1.O.[Li+].[OH-]>>CSc1cc(-c2ccco2)nc(C(=O)O)c1OCc1ccccc1",
        "output": "152"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COC(=O)C(Cc1ccccc1)NC(=O)c1ccc(-c2ccc(O)cc2)cc1.Cc1cccc(CBr)c1>>COC(=O)C(Cc1ccccc1)NC(=O)c1ccc(-c2ccc(OCc3cccc(C)c3)cc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cc(C)c2sccc(=O)c2c1C.CCOC(=O)c1cc(Cl)c2c(c1C)C(=O)CCS2>>Cc1cc(C(=O)O)c(C)c2c(=O)ccsc12",
        "output": "5"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.C[O-].Cc1ccnc(F)c1-c1ccc2cc(N)ncc2c1.O=C([O-])O.[Na+].[Na+]>>COc1nccc(C)c1-c1ccc2cc(N)ncc2c1",
        "output": "541"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCc2c(C(=O)O)n[nH]c2C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.Fc1cc(F)c(C(F)(F)F)c(C2CCNCC2)c1.O>>CC(C)(C)OC(=O)N1CCc2c(C(=O)N3CCC(c4cc(F)cc(F)c4C(F)(F)F)CC3)n[nH]c2C1",
        "output": "663"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(C)=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1OCC(F)(F)F.OC1CCNCC1.[K+].[K+]>>O=[N+]([O-])c1ccc(N2CCC(O)CC2)cc1OCC(F)(F)F",
        "output": "26"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.N#Cc1ccc(-c2cc(N3CCOC(c4nc5cc(Cl)ccc5[nH]4)C3)nc(N)n2)cc1F.NN.O>>Nc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2CCOC(c3nc4cc(Cl)ccc4[nH]3)C2)n1",
        "output": "945"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.COCCCO.Oc1ccccc1I.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COCCCOc1ccccc1I",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.C[C@H](Nc1nccc(N(C)c2ccnc(-c3ccccc3)n2)n1)c1ccc(CCNC(=O)OCc2ccccc2)cc1.[Pd]>>C[C@H](Nc1nccc(N(C)c2ccnc(-c3ccccc3)n2)n1)c1ccc(CCN)cc1",
        "output": "574"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COc1ccc(Cl)cc1S(=O)(=O)Cl.NCC(NC(=O)OCc1ccccc1)C(=O)O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>COc1ccc(Cl)cc1S(=O)(=O)NCC(NC(=O)OCc1ccccc1)C(=O)O",
        "output": "43"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cc1nc(N[C@H]2CC[C@@H](CNC(=O)OCc3ccccc3)CC2)cc(N(C)C)n1.[Pd]>>Cc1nc(N[C@H]2CC[C@@H](CN)CC2)cc(N(C)C)n1",
        "output": "574"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCCNCC1.Cc1nc2ccc(Br)cc2c(-c2ccc(F)cc2)c1C(=O)C(F)(F)F>>Cc1nc2ccc(N3CCCCCC3)cc2c(-c2ccc(F)cc2)c1C(=O)C(F)(F)F",
        "output": "294"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(C)(C)c1ccc(N)c([N+](=O)[O-])c1.CCO.O.[Ca+2].[Cl-].[Cl-].[Fe]>>CCC(C)(C)c1ccc(N)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCc1ccc(Cl)cc1Cl.Nc1nc(N)c2c(N3CCNCC3)cccc2n1>>Nc1nc(N)c2c(N3CCN(Cc4ccc(Cl)cc4Cl)CC3)cccc2n1",
        "output": "156"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)Nc1cc(F)c(Cl)cc1F.O=S(=O)(O)O.O=[N+]([O-])O>>CCOC(=O)Nc1c(F)cc(Cl)c(F)c1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC=C(c2ccc3[nH]ncc3c2)CC1.CO.[Pd]>>CC(C)(C)OC(=O)N1CCC(c2ccc3[nH]ncc3c2)CC1",
        "output": "806"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCOC(=O)C1(NC(=O)c2cccnc2N(C)CC)Cc2ccccc2C1.CO.O>>CCN(C)c1ncccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN.Cl.O=S1(=O)N(CCCCBr)Cc2ccccc2N1c1ccccc1F>>CNCCCCN1Cc2ccccc2N(c2ccccc2F)S1(=O)=O",
        "output": "147"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)Nc1cc(C#N)cc(N2CCOC(C(=O)N3CCOCC3)C2)c1Cl.ClCCl.O=C(O)C(F)(F)F>>N#Cc1cc(N)c(Cl)c(N2CCOC(C(=O)N3CCOCC3)C2)c1",
        "output": "782"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCOCCN.CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CC(=O)N(C)C)c1=O>>CCCOCCNC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CC(=O)N(C)C)c1=O",
        "output": "498"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCc1nc2c(N)nc3cc(OCCCNC(=O)OC(C)(C)C)ccc3c2s1.CCO.Cl>>CCCc1nc2c(N)nc3cc(OCCCN)ccc3c2s1",
        "output": "538"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(c1cccc(-c2cccn3nc(N)nc23)c1)S(C)(=O)=O.CN1CCC(c2cccc(Br)c2)CC1.Cl.c1ccc(P(C2CCCCC2)C2CCCCC2)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c1>>CN1CCC(c2cccc(Nc3nc4c(-c5cccc(N(C)S(C)(=O)=O)c5)cccn4n3)c2)CC1",
        "output": "970"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCOCC.CCOc1ccc(C(=O)c2cc(Br)c3c(c2Cl)CC(C)O3)cc1.CC[SiH](CC)CC.ClCCl.FB(F)F.O=C([O-])[O-].[K+].[K+]>>CCOc1ccc(Cc2cc(Br)c3c(c2Cl)CC(C)O3)cc1",
        "output": "181"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COCC(COC)n1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)OC)cc4)cc3)nc21.Cl.O.[Na+].[OH-]>>COCC(COC)n1ncc2c(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)O)cc4)cc3)nc21",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)N(C)C.CCNCC.N#Cc1ccc(Br)c(C(F)(F)F)c1.O=C([O-])O.[Na+]>>CCN(CC)c1ccc(C#N)cc1C(F)(F)F",
        "output": "294"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO[C@@H]1CN(CCn2c(=O)ccc3ccc(C#N)cc32)CC[C@H]1NC(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CO[C@@H]1CN(CCn2c(=O)ccc3ccc(C#N)cc32)CC[C@H]1N",
        "output": "538"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.ClCCl.N#Cc1cnc(Cl)c(Cl)c1>>CC(C)(C)OC(=O)N1CCN(c2ncc(C#N)cc2Cl)CC1",
        "output": "220"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Cl.N#Cc1c(F)cc(-c2ccnn2C2CCCCO2)cc1Cl.O.O=C([O-])O.[Na+]>>N#Cc1c(F)cc(-c2ccn[nH]2)cc1Cl",
        "output": "689"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.COc1ccc(Oc2ccc([N+](=O)[O-])cc2)c2ccccc12.[Pd]>>COc1ccc(Oc2ccc(N)cc2)c2ccccc12",
        "output": "335"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CCNCC2)nc1C(F)(F)F.O=C=Nc1ccc2ccccc2c1>>CCOC(=O)c1cc(C#N)c(N2CCN(C(=O)Nc3ccc4ccccc4c3)CC2)nc1C(F)(F)F",
        "output": "323"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=C1CCOc2ccc(Br)cc21.[Fe+2].[K+].c1ccc(P(c2ccccc2)c2ccc[cH-]2)cc1.c1ccc(P(c2ccccc2)c2ccc[cH-]2)cc1>>CC1(C)OB(c2ccc3c(c2)C(=O)CCO3)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.COC(C[C@H]1NC(=O)[C@@H]1N1C(=O)c2ccccc2C1=O)OC>>O=CC[C@H]1NC(=O)[C@@H]1N1C(=O)c2ccccc2C1=O",
        "output": "234"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.CCN(CC)c1ccc(N)cc1.CCOC(C)=O.Cl.Nc1cc(Cl)ncn1.O=C([O-])[O-].[K+].[K+]>>CCN(CC)c1ccc(Nc2cc(N)ncn2)cc1",
        "output": "161"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.Cn1cncc1C(O)c1ccc(C#N)c(Br)c1.N#Cc1ccc(CBr)cc1.O=[Ag-]>>Cn1cncc1C(OCc1ccc(C#N)cc1)c1ccc(C#N)c(Br)c1",
        "output": "464"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)CC(c1ccccc1)n1cnc2cc(C(=O)O)ccc21.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.c1cnc(N2CCNCC2)cn1>>CCOC(=O)CC(c1ccccc1)n1cnc2cc(C(=O)N3CCN(c4cnccn4)CC3)ccc21",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN.O.O=[N+]([O-])c1ccc(Cl)c([N+](=O)[O-])c1.[Na+].[OH-]>>CNc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]",
        "output": "304"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.O=C=NCc1ccccc1Cl.OC[C@@H]1CCCN1>>O=C(NCc1ccccc1Cl)N1CCC[C@H]1CO",
        "output": "583"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.ClCCl.N.N#CC[C@@H](O)c1cccc(OCC2CCCCCC2)n1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCC[C@@H](O)c1cccc(OCC2CCCCCC2)n1",
        "output": "246"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C(O)C([NH3+])Cc1ccccc1.Cc1cn(-c2ncccc2C(=O)O)nc1-c1ccccc1.[Cl-]>>CCOC(=O)C(O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1cc(C)c(-c2ccccc2)n1",
        "output": "674"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1CCNCC1.CC(C)(C)[O-].CCCCCC.CCOC(C)=O.CCc1cc(OC)ccc1Br.Cc1ccccc1.P.[Na+].[Pd+2]>>CCc1cc(OC)ccc1N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "294"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1(C(=O)O)CC1.[Na+].[OH-]>>CC(C)(C)OC(=O)NC1(C(=O)O)CC1",
        "output": "626"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)N1C2C=C(c3ccc4ccccc4c3)CC1CC2.O=C[O-].[NH4+].[Pd]>>CCOC(=O)N1C2CCC1CC(c1ccc3ccccc3c1)C2",
        "output": "806"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1cc(-n2nnnc2SC)ccc1OC.O.[Li+].[OH-]>>COc1ccc(-n2nnnc2SC)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.COCC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(CO[Si](C)(C)C(C)(C)C)cc3)c3ccccc23)ccn1.[F-]>>COCC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(CO)cc3)c3ccccc23)ccn1",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)Oc1cc(C#C[Si](C)(C)C)cc2c1C(=O)CCC2(C)C.CO.O=C([O-])[O-].[K+].[K+]>>C#Cc1cc(OC(C)C)c2c(c1)C(C)(C)CCC2=O",
        "output": "337"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#Cc1cccnc1.CCN(CC)CC.CS(C)=O.O=C(NC1CC1)c1nn(-c2cccc(Br)c2)c2ncccc2c1=O.[Cu]I>>O=C(NC1CC1)c1nn(-c2cccc(C#Cc3cccnc3)c2)c2ncccc2c1=O",
        "output": "659"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.ClCCl.NCCO.Nc1cccnc1N1CCN(C(=O)c2ccc(C(=O)O)cn2)CC1.On1nnc2ccccc21>>Nc1cccnc1N1CCN(C(=O)c2ccc(C(=O)NCCO)cn2)CC1",
        "output": "674"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "NC1CCC(Nc2ccc3ccccc3n2)CC1.O=CC12CC(c3ccccc31)c1ccccc12>>c1ccc2c(c1)C1CC2(CNC2CCC(Nc3ccc4ccccc4n3)CC2)c2ccccc21",
        "output": "426"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc(-c2cnn3c(-c4cccc(NC(=O)c5cccc(C(F)(F)F)c5)c4)ccnc23)c1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li+].[OH-]>>O=C(O)c1cccc(-c2cnn3c(-c4cccc(NC(=O)c5cccc(C(F)(F)F)c5)c4)ccnc23)c1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.CC(=O)O.COc1ccc(Cl)cc1Nc1nc(C)c(C(C)=O)s1.[Br-].[Br-].[Br-].c1cc[nH+]cc1.c1cc[nH+]cc1.c1cc[nH+]cc1>>COc1ccc(Cl)cc1Nc1nc(C)c(C(=O)CBr)s1",
        "output": "360"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)Cc1ccc(C2=CCCCC2)cc1.[Na+].[OH-]>>O=C(O)Cc1ccc(C2=CCCCC2)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cnn2ccc(OC)cc12.[Li+].[OH-]>>COc1ccn2ncc(C(=O)O)c2c1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCc1cc(N2CCS(=O)(=O)c3ccccc3C2)nc2ccc(CC)cc12.CO.Cl.[Li+].[OH-]>>CCc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(CCC(=O)O)c2c1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.O=[Cr](=O)([O-])Cl.OCc1ccc(Br)c(Cl)c1.c1cc[nH+]cc1>>O=Cc1ccc(Br)c(Cl)c1",
        "output": "179"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "B.C1CCOC1.CSC.CSc1cc(Br)cc(F)c1C(=O)O>>CSc1cc(Br)cc(F)c1CO",
        "output": "72"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.N#Cc1cc([N+](=O)[O-])ccc1N1CCCCC1.O.[Cl-].[Fe].[NH4+]>>N#Cc1cc(N)ccc1N1CCCCC1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCN(C2CCNCC2)C1.COc1ccccc1-c1cc(Cl)nc2c1C(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)CCCO2>>COc1ccccc1-c1cc(N2CCC(N3CCCC3)CC2)nc2c1C(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)CCCO2",
        "output": "220"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br.CC(=O)Nc1cc(=O)n(OCc2ccccc2)c2ncccc12>>CC(=O)Nc1cc(=O)n(O)c2ncccc12",
        "output": "630"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CCN(CC)CC.ClCCl.O=S(=O)(Cl)c1ccc(F)cc1F>>CC(C)(C)OC(=O)N1CCC(NS(=O)(=O)c2ccc(F)cc2F)CC1",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CO.Cc1ccc(C(=O)Nc2ccc(C(O)CCc3ccccn3)cc2)c(-c2ccc(C(F)(F)F)cc2)c1.Cl.[H][H].[Pd]>>Cc1ccc(C(=O)Nc2ccc(CCCc3ccccn3)cc2)c(-c2ccc(C(F)(F)F)cc2)c1",
        "output": "447"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1c(CSc2nccn2C)nc2cc(OC)c(OC)cc2c1-c1ccc(OC)c(OC)c1.ClCCl.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)c1c(CS(=O)c2nccn2C)nc2cc(OC)c(OC)cc2c1-c1ccc(OC)c(OC)c1",
        "output": "595"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)C(Oc1cc(OC)nc(OC)n1)C(OC)(c1ccccc1)c1ccccc1.O.[K+].[OH-]>>COc1cc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc(OC)n1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)c1ccncc1.CS[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O.ClC(Cl)Cl.ClCCCl>>CS[C@@H]1O[C@H](CO[Si](C)(C)C(C)(C)C)[C@H](O)[C@H](O)[C@H]1O",
        "output": "193"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#CCCCO.CC=Cc1cccc(C#CCCC=O)c1>>CC=Cc1cccc(C#CCCCO)c1",
        "output": "223"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(C)=O.CC[C@@H](C)Oc1ccc([N+](=O)[O-])cc1.[Pd]>>CC[C@@H](C)Oc1ccc(N)cc1",
        "output": "202"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.CC(C)[O-].O=C(O)c1cc(Cl)nc(Cl)c1.[Na+]>>CC(C)Oc1cc(C(=O)O)cc(Cl)n1",
        "output": "433"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCOCc1cc(C)nc(OC)c1CN.C=CCc1c(C(=O)O)cccc1N(CC)C1CCOCC1.CN(C)C=O.CN1CCOCC1.ClCCCl.O.On1nnc2cccnc21>>C=CCOCc1cc(C)nc(OC)c1CNC(=O)c1cccc(N(CC)C2CCOCC2)c1CC=C",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCOC(=O)Cl.C[C@@H](O)CN.O.[Na+].[OH-]>>CCOC(=O)NC[C@@H](C)O",
        "output": "94"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)[O-].CCO.Cl.NO.O.O=Cc1ccc(N2CCC3(CC2)OCCO3)cc1.[Na+]>>ON=Cc1ccc(N2CCC3(CC2)OCCO3)cc1",
        "output": "30"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cl[Sn]Cl.O=[N+]([O-])c1ccc(S(=O)(=O)Nc2ccccc2OC(F)(F)F)cc1>>Nc1ccc(S(=O)(=O)Nc2ccccc2OC(F)(F)F)cc1",
        "output": "401"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(=O)(=O)OCC[C@@H]1OCCc2cc(Br)ccc21.C[C@@H]1CN(c2csc3cc(C#N)ccc23)CCN1>>C[C@@H]1CN(c2csc3cc(C#N)ccc23)CCN1CC[C@@H]1OCCc2cc(Br)ccc21",
        "output": "496"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COc1ccc(-c2cc(=O)c3ccc(OCC4CO4)cc3o2)cc1OC.c1ccc(N2CCNCC2)cc1>>COc1ccc(-c2cc(=O)c3ccc(OCC(O)CN4CCN(c5ccccc5)CC4)cc3o2)cc1OC",
        "output": "76"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cc2ncnc(C3CCNCC3)c2cc1OC.ClCCl.O=C(Nc1ccc(OC2CCCC2)nc1)Oc1ccc([N+](=O)[O-])cc1>>COc1cc2ncnc(C3CCN(C(=O)Nc4ccc(OC5CCCC5)nc4)CC3)c2cc1OC",
        "output": "770"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CCCCCC.Nc1cccc2ccc(O)cc12.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>O=[N+]([O-])c1ccc(S(=O)(=O)Nc2cccc3ccc(O)cc23)cc1",
        "output": "68"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(=O)N1CC(C)(C)c2ccc(N3CCOCC3)cc21.Cl.O=C([O-])O.[Na+]>>CC1(C)CNc2cc(N3CCOCC3)ccc21",
        "output": "504"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.O=S(=O)(CCn1c2ccccc2c2ccccc21)c1ccccc1.O=[N+]([O-])[O-].[Ce].[NH4+]>>O=[N+]([O-])c1ccc2c(c1)c1ccccc1n2CCS(=O)(=O)c1ccccc1",
        "output": "103"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=C1CCCN1c1cccc([N+](=O)[O-])c1.[H][H].[Pd]>>Nc1cccc(N2CCCC2=O)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCCN(CCC)Cc1ccc(NC(=O)c2ccc(CNC(=O)OC(C)(C)C)cc2)cc1.CO.Cl>>CCCN(CCC)Cc1ccc(NC(=O)c2ccc(CN)cc2)cc1",
        "output": "793"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(O)cc1.CCOC(=O)CBr.CN(C)C=O.ClC(Cl)Cl.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)COc1ccc(NC(=O)OC(C)(C)C)cc1",
        "output": "123"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccccc1.Cc1cnc(S(C)(=O)=O)nc1-c1ccc(Br)s1.NCCN1CCNC1=O>>Cc1cnc(NCCN2CCNC2=O)nc1-c1ccc(Br)s1",
        "output": "629"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCCC=O.CSc1ccc(/C=C2/C(C)=C(CCON)c3cc(F)ccc32)cc1>>COCCC=NOCCC1=C(C)/C(=C/c2ccc(SC)cc2)c2ccc(F)cc21",
        "output": "118"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNC1.C1CCOC1.CCOC(=O)c1cc2cc(C(=O)CCl)ccc2[nH]1.CCOC(C)=O.CN1CCCC1=O>>CCOC(=O)c1cc2cc(C(=O)CN3CCCC3)ccc2[nH]1",
        "output": "414"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(c1ccc(N(C)c2ccc(O)cc2)cc1)C1CC1.Oc1nc(Cl)nc2cnccc12>>CC(c1ccc(N(C)c2ccc(Oc3nc(O)c4ccncc4n3)cc2)cc1)C1CC1",
        "output": "542"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)Cc1ccc(C#N)c(OC)c1.CO.[Li+].[OH-]>>COc1cc(CC(=O)O)ccc1C#N",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C[C@@H](CCl)CBr.Oc1cccc(Cl)c1>>C[C@@H](CCl)COc1cccc(Cl)c1",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1CCCO1.CCN(CC)CC.CCOC(=O)Cl.CCOC(C)=O.Nc1cc(C(F)(F)F)nc(Cl)c1[N+](=O)[O-]>>CCOC(=O)Nc1cc(C(F)(F)F)nc(Cl)c1[N+](=O)[O-]",
        "output": "102"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCc2ccc(C(C#N)Cc3ccccc3)cc2C1.O=C([O-])O.O=CO.[Na+]>>N#CC(Cc1ccccc1)c1ccc2c(c1)CNCC2",
        "output": "887"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN.ClCCl.O=S(=O)(Cl)c1ccc(Br)cc1C(F)(F)F>>CCNS(=O)(=O)c1ccc(Br)cc1C(F)(F)F",
        "output": "43"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCc1nc(CO)n(Cc2ccccn2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCCc1nc(CO)n(Cc2ccccn2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCN.O=C(Cl)C(c1ccccc1)c1ccccc1>>CCCCCCNC(=O)C(c1ccccc1)c1ccccc1",
        "output": "45"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=CC(=O)N1CC(N2CCNCC2C)C1.CCN(CC)CC.CCOC(=O)Cl.CN1CCOCC1.Cl.ClCCl.O=C(O)CNc1cc(C2CC2)c(Cl)cc1O>>C=CC(=O)N1CC(N2CCN(C(=O)CNc3cc(C4CC4)c(Cl)cc3O)CC2C)C1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Cc1ccccc1-c1cc(N2CCOCC2)nc2ccc(NC(=O)OC(C)(C)C)cc12.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CNc1ccc2nc(N3CCOCC3)cc(-c3ccccc3C)c2c1",
        "output": "881"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COc1cc2c(c([N+](=O)[O-])c1OC)c(=O)c(C(=O)O)cn2C1CC1.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[S-2]>>COc1cc2c(c(N)c1OC)c(=O)c(C(=O)O)cn2C1CC1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.Cl[Sn]Cl.O=C([O-])[O-].O=C(c1cc([N+](=O)[O-])ccc1F)N1CCOCC1.[K+].[K+]>>Nc1ccc(F)c(C(=O)N2CCOCC2)c1",
        "output": "489"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(C)=O.O.OCc1ccc2[nH]nc(COC3CCCCO3)c2c1>>O=Cc1ccc2[nH]nc(COC3CCCCO3)c2c1",
        "output": "179"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Nc1cccc(Oc2ccnc3[nH]c(=O)[nH]c23)c1.O=C(Cl)c1ccc(C(F)(F)F)cc1>>O=C(Nc1cccc(Oc2ccnc3[nH]c(=O)[nH]c23)c1)c1ccc(C(F)(F)F)cc1",
        "output": "11"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.Cc1ccc2c(c1)nc(C(C)(C)O)n2C1CCN(C(=O)C2Cc3ccc(NC(=O)OC(C)(C)C)cc3C2)CC1.Cl>>Cc1ccc2c(c1)nc(C(C)(C)O)n2C1CCN(C(=O)C2Cc3ccc(N)cc3C2)CC1",
        "output": "782"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(N)CC2)n1.O=C(O)c1cncnc1>>Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3cncnc3)CC2)n1",
        "output": "989"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C(O)c1cnc2c(Cl)cccc2c1O.O=S(Cl)Cl>>O=C(Cl)c1cnc2c(Cl)cccc2c1O",
        "output": "188"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1c(N2CCOCC2)n(C2CC2)c2cc(OCc3nc(C(C)C)cs3)c(F)cc2c1=O.CSC.ClC(Cl)Cl.ClCCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(C)c1csc(COc2cc3c(cc2F)c(=O)c(C(=O)O)c(N2CCOCC2)n3C2CC2)n1",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CNCCN(C)C.COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)[nH]c2c1OCCCCCCCl>>COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)[nH]c2c1OCCCCCCN(C)CCN(C)C",
        "output": "138"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CN2CCN1CC2.CC1(C)CC(OC(=O)Nc2ccccc2)CC(C)(C)N1CC(O)c1ccccc1.O=C=Nc1ccccc1.c1ccccc1>>CC1(C)CC(OC(=O)Nc2ccccc2)CC(C)(C)N1CC(OC(=O)Nc1ccccc1)c1ccccc1",
        "output": "34"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)Cc1ccc2c(c1)NC(=O)CS2.Cl.O.O.O.[Li]O>>O=C(O)Cc1ccc2c(c1)NC(=O)CS2",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.ClCCl.OCCc1c(Cl)nc2ccnn2c1Cl.[Cl-].[NH4+]>>CC(C)(C)[Si](C)(C)OCCc1c(Cl)nc2ccnn2c1Cl",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc2c(c1)Sc1ccc(SC)cc1C(N1CCNCC1)C2.Cc1ccccc1.O=C([O-])[O-].O=C1CCCN1CCCl.[I-].[K+].[K+].[Na+]>>COc1ccc2c(c1)Sc1ccc(SC)cc1C(N1CCN(CCN3CCCC3=O)CC1)C2",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.Fc1ccc2cccnc2c1F.O=C1CCC(=O)N1I>>Fc1ccc2cc(I)cnc2c1F",
        "output": "783"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCCCCC.CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1C(=O)OCC.Cl.[H-]>>CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CO",
        "output": "471"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCn1cc(-c2ccnc3[nH]ccc23)c(-c2ccc(N)cc2)n1.O=C(Cl)Cc1cccs1>>CCn1cc(-c2ccnc3[nH]ccc23)c(-c2ccc(NC(=O)Cc3cccs3)cc2)n1",
        "output": "9"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)Nc1cc(Cl)c(C(F)(F)F)cc1NC(=O)CC(=O)c1cccc(-c2ccnc(C(F)(F)F)c2)c1.ClCCl.O=C(O)C(F)(F)F>>O=C1CC(c2cccc(-c3ccnc(C(F)(F)F)c3)c2)=Nc2cc(Cl)c(C(F)(F)F)cc2N1",
        "output": "930"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)c1ccc(NCC(F)(F)F)cc1.O.[K+].[OH-]>>O=C(O)c1ccc(NCC(F)(F)F)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.N#CC1(c2cccc([N+](=O)[O-])c2)CC1.[Pd]>>N#CC1(c2cccc(N)c2)CC1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)Cl.C[C@@H](N)c1ccc(Br)cc1.ClCCl.c1ccncc1>>C[C@@H](NS(C)(=O)=O)c1ccc(Br)cc1",
        "output": "742"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(-c2ccc(CN)cn2)ccn1.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(Oc2ccccc2)nc1>>Cc1cc(-c2ccc(CNC(=O)c3ccc(Oc4ccccc4)nc3)cn2)ccn1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)C=O.COC(=O)C[C@@H]1CC[C@@H](NCC2CCCC2)[C@H](c2ccc(C(F)(F)F)cc2)O1.[Na+]>>COC(=O)C[C@@H]1CC[C@@H](N(CC(C)C)CC2CCCC2)[C@H](c2ccc(C(F)(F)F)cc2)O1",
        "output": "484"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)Cc1ccccc1Oc1ccccc1.NN.O.O>>NNC(=O)Cc1ccccc1Oc1ccccc1",
        "output": "130"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)N(C)C.CCC(Cc1ccccc1)(C(=O)c1ccc(F)cc1)N(C)C.NCCCO.O.O=C([O-])[O-].[K+].[K+]>>CCC(Cc1ccccc1)(C(=O)c1ccc(NCCCO)cc1)N(C)C",
        "output": "572"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCO.NC1CCOCC1.Nc1nc(Cl)c(N)c(Cl)n1.O=C([O-])O.[Na+]>>Nc1nc(Cl)c(N)c(NC2CCOCC2)n1",
        "output": "166"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C/C=C/C(=O)O.C1CCOC1.CCN(C(C)C)C(C)C.NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn(C2CCCNC2)c1N>>C/C=C/C(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c(C(N)=O)c2N)C1",
        "output": "870"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1cc(Br)cc(OC)c1.ClCCl>>Oc1cc(O)cc(Br)c1",
        "output": "20"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCN1CCC(NC(=O)c2cc(F)c(N)cc2F)CC1.CN1C(=O)C2(CC2)CN(C2CCCC2)c2nc(Cl)ncc21.O=C([O-])[O-].[Cs+].[Cs+]>>CCN1CCC(NC(=O)c2cc(F)c(Nc3ncc4c(n3)N(C3CCCC3)CC3(CC3)C(=O)N4C)cc2F)CC1",
        "output": "941"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCOC(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)C[C@H]1CCOS(C)(=O)=O.CCOC(C)=O.CN(C)C=O.O.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>C=CCOC(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)C[C@H]1CCN=[N+]=[N-]",
        "output": "322"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)CC(c1nc2cc(C#N)ccc2[nH]1)c1c(OC)cc(C)c2[nH]ccc12.O.[Na+].[OH-]>>COc1cc(C)c2[nH]ccc2c1C(CC(=O)O)c1nc2cc(C#N)ccc2[nH]1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CCBr.CN(C)C=O.O=[N+]([O-])c1ccc(O)c(Br)c1.[H-].[Na+]>>C=CCOc1ccc([N+](=O)[O-])cc1Br",
        "output": "77"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CN1CCOCC1.CNOC.COc1nc(Cl)nc(OC)n1.O=C(O)COc1ccc(Br)cc1>>CON(C)C(=O)COc1ccc(Br)cc1",
        "output": "54"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)C(C)(C)c1cccc(C#N)c1.O.[Li+].[OH-]>>CC(C)(C(=O)O)c1cccc(C#N)c1",
        "output": "203"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=CCBr.CN(C)C=O.Cc1ccccc1-c1ccc(O)cc1.O>>C=CCOc1ccc(-c2ccccc2C)cc1",
        "output": "77"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1c(N2CCC(F)(F)CC2)nc2ccc(Cl)cc2c1-c1ccccc1.[Na+].[OH-]>>O=C(O)c1c(N2CCC(F)(F)CC2)nc2ccc(Cl)cc2c1-c1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cn(Cc2ccccc2)nc1OCc1ccc(OCc2nc(-c3ccco3)oc2C)c(OCc2ccccc2)c1.CCOC(C)=O.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>Cc1oc(-c2ccco2)nc1COc1ccc(COc2nn(Cc3ccccc3)cc2CO)cc1OCc1ccccc1",
        "output": "471"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(OC)c(N)c1.O=C(Cl)Cc1ccccc1.O=C([O-])[O-].[Na+].[Na+].c1ccccc1>>COc1ccc(OC)c(NC(=O)Cc2ccccc2)c1",
        "output": "9"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "N=C1NC(=O)C(Cc2ccc(N3CCC(=O)CC3)cc2)S1.NC[C@H](O)COc1cccc2[nH]c(=O)[nH]c12>>N=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)COc4cccc5[nH]c(=O)[nH]c45)CC3)cc2)S1",
        "output": "236"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)C1(NC(=O)CC(c2ccccc2)c2ccccc2)CCCCC1.O.[Li+].[OH-]>>O=C(CC(c1ccccc1)c1ccccc1)NC1(C(=O)O)CCCCC1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(Cn2ncc3c(C#Cc4cnc5ccc(-c6ccc(C(=O)N7CCOCC7)cc6)cn45)ccnc32)cc1.O=C(O)C(F)(F)F>>O=C(c1ccc(-c2ccc3ncc(C#Cc4ccnc5[nH]ncc45)n3c2)cc1)N1CCOCC1",
        "output": "978"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CCBr.CC#N.Cc1ccc(Cl)c(O)c1.O=C([O-])[O-].[K+].[K+]>>C=CCOc1cc(C)ccc1Cl",
        "output": "77"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1cc(-c2ncnc(-c3cccnc3C(F)(F)F)n2)cc([N+](=O)[O-])c1OC.ClCCl>>O=[N+]([O-])c1cc(-c2ncnc(-c3cccnc3C(F)(F)F)n2)cc(O)c1O",
        "output": "19"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)Cc2c(ccc3c2C(c2cccc(-c4ccc(C(=O)O)cc4)c2)=NCC3(C)C)O1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.On1nnc2ccccc21.[NH4+]>>CC1(C)Cc2c(ccc3c2C(c2cccc(-c4ccc(C(N)=O)cc4)c2)=NCC3(C)C)O1",
        "output": "358"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCC[C@@H](C)Oc1ccc(-c2ccc(O)cc2)cc1.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CCCCCC[C@@H](C)Oc1ccc(-c2ccc(OS(=O)(=O)C(F)(F)F)cc2)cc1",
        "output": "731"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.Nc1ccc([N+](=O)[O-])cc1Cl.O.c1ccncc1>>Cc1ccc(S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2Cl)cc1",
        "output": "68"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CO.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(-c2cnc3ncc(C4(c5ccc6ncccc6c5)CC4)n3c2)c(F)c1>>CNC(=O)c1ccc(-c2cnc3ncc(C4(c5ccc6ncccc6c5)CC4)n3c2)c(F)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC[C@H]1CN(c2ccc3c(c2)CCN(C(=O)OCc2ccccc2)C3)C(=O)O1.O.O.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)NC[C@H]1CN(c2ccc3c(c2)CCN(C(=O)OCc2ccccc2)C3)C(=O)O1",
        "output": "631"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccc(Br)cc1.CCC(C)=O.CCOC(C)=O.O=C([O-])[O-].O=C1Nc2ccccc2C12COc1cc3c(cc12)OCO3.[Cs+].[Cs+]>>O=C1N(Cc2ccc(Br)cc2)c2ccccc2C12COc1cc3c(cc12)OCO3",
        "output": "688"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)OCC[C@@H]1OCCc2cc(-c3cccnc3)ccc21.C[C@@H]1CN(c2cccc3cc(C#N)ccc23)CCN1>>C[C@@H]1CN(c2cccc3cc(C#N)ccc23)CCN1CC[C@@H]1OCCc2cc(-c3cccnc3)ccc21",
        "output": "496"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)c1cc2c(cc1Cl)N(C(=O)OC(C)(C)C)CC(C(=O)N1CCC(C#N)(Cc3ccc(F)nc3)CC1)O2.ClCCl.O=C(O)C(F)(F)F>>CN(C)c1cc2c(cc1Cl)NCC(C(=O)N1CCC(C#N)(Cc3ccc(F)nc3)CC1)O2",
        "output": "830"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.C1CCNCC1.CC(=O)O.CCO.O=C1Cc2ccccc2N1.O=Cc1[nH]c2c(c1CCC(=O)O)CCCC2>>O=C(O)CCc1c(C=C2C(=O)Nc3ccccc32)[nH]c2c1CCCC2",
        "output": "440"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.Cc1ccc(N)cc1[N+](=O)[O-].ClCCl.O=C(Cl)c1cccc(C(F)(F)F)c1>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1[N+](=O)[O-]",
        "output": "11"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CSCC[C@H](N)C(N)=O.Cl.O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1>>CSCC[C@H](NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(N)=O",
        "output": "738"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOCC.CN(C)C=O.Cc1cscc1C.Cl.[Li]CCCC>>Cc1csc(C=O)c1C",
        "output": "617"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCS.COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2ccc(OC3CCCN(C)C3)cc2)cc1.[Al+3].[Cl-].[Cl-].[Cl-]>>CN1CCCC(Oc2ccc(C(=O)c3c(-c4ccc(O)cc4)sc4cc(O)ccc34)cc2)C1",
        "output": "20"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(Cc1ccc(Cl)c(Cl)c1)C(=O)C1=C(O)C(=O)N(CCCC(=O)O)C1.NS(=O)(=O)C1(c2ccccc2)CC1>>CN(Cc1ccc(Cl)c(Cl)c1)C(=O)C1=C(O)C(=O)N(CCCC(=O)NS(=O)(=O)C2(c3ccccc3)CC2)C1",
        "output": "644"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.Br.CC(=O)N(C)C.COc1ccc(CCCl)cc1.O=C([O-])[O-].Oc1ncnc2nc(CC3CCNCC3)n(Cc3ccc(F)cc3)c12.[Na+].[Na+]>>COc1ccc(CCN2CCC(Cc3nc4ncnc(O)c4n3Cc3ccc(F)cc3)CC2)cc1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(=O)(=O)c1ccc(N2CCNCC2)c(F)c1.CS(=O)(=O)c1ccc(SCC(F)(F)F)c(C(=O)O)c1>>CS(=O)(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3SCC(F)(F)F)CC2)c(F)c1",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCc2ccc(B3OC(C)(C)C(C)(C)O3)cc2CC1.COC(=O)c1ccc(Cl)nc1>>COC(=O)c1ccc(-c2ccc3c(c2)CCN(C(=O)OC(C)(C)C)CC3)nc1",
        "output": "955"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br.Br.CC(=O)N(C)C.CCN(C(C)C)C(C)C.ClCCCl.N#Cc1ccc(-c2nnc(Cc3cccc(C(=O)O)c3)o2)cc1.Nc1nc2c(s1)C[C@@H](N1CCOCC1)CC2.O.O=C([O-])O.[Na+]>>N#Cc1ccc(-c2nnc(Cc3cccc(C(=O)Nc4nc5c(s4)C[C@@H](N4CCOCC4)CC5)c3)o2)cc1",
        "output": "918"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1ccc(Cn2ccnc2)cn1.Nc1ccccc1B(O)O>>Nc1ccccc1-c1ccc(Cn2ccnc2)cn1",
        "output": "869"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.Cl.N#Cc1cccc(Cc2cccc3nc(Nc4ccccc4)nn23)c1.O.OO.[Na+].[OH-]>>NC(=O)c1cccc(Cc2cccc3nc(Nc4ccccc4)nn23)c1",
        "output": "180"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.ClC(Cl)Cl.FC(F)(F)c1nc(Cl)c2sc(Cl)nc2n1.O=C(NCc1ccc(OC(F)F)c(F)c1)[C@H]1CNCCN1S(=O)(=O)c1ccc(OC(F)(F)F)cc1>>O=C(NCc1ccc(OC(F)F)c(F)c1)[C@H]1CN(c2nc3nc(C(F)(F)F)nc(Cl)c3s2)CCN1S(=O)(=O)c1ccc(OC(F)(F)F)cc1",
        "output": "558"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCCCCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.CCOC(C)=O.CN(C)Cc1c(OCC2CC2)ccc2c(CCC3CCNCC3)noc12.Clc1ncccn1.O.O.[F-].[Na+].[OH-]>>CN(C)Cc1c(OCC2CC2)ccc2c(CCC3CCN(c4ncccn4)CC3)noc12",
        "output": "36"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)[Mg]Cl.COC(=O)c1ccc(C)c(-n2cc(Cl)nc(N3CCN(C)CC3)c2=O)c1.NC1CC1.[Cl-].[NH4+]>>Cc1ccc(C(=O)NC2CC2)cc1-n1cc(Cl)nc(N2CCN(C)CC2)c1=O",
        "output": "338"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CCO.CCOC(=O)C1CC1c1ccc(OC)c(C)c1C.ClCCl.O=C([O-])O.[Na+]>>CCOC(=O)C1CC1c1ccc(O)c(C)c1C",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)[O-].CCO.Cl.NO.O.O=C1CC[C@H](c2ccccc2)C1.[Na+]>>ON=C1CC[C@H](c2ccccc2)C1",
        "output": "86"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.CCO.COc1ccc(-c2cn3cccnc3n2)c2ccccc12.ClCCl>>Oc1ccc(-c2cn3cccnc3n2)c2ccccc12",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(N1CC(CCl)c2c1ccc1ccccc21)C(F)(F)F.O=S(=O)(O)Cl>>O=C(N1CC(CCl)c2c1ccc1cc(S(=O)(=O)Cl)ccc21)C(F)(F)F",
        "output": "182"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)CCN.CC(=O)N(C)C.CCN(CC)CC.CCOC(C)=O.Cl.O=C(Cl)Cc1ccc(F)cc1.O=C([O-])O.[Na+]>>CC(=O)CCNC(=O)Cc1ccc(F)cc1",
        "output": "45"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccccc1C.O=C(O)Cc1ccccc1Cl.O=C([O-])[O-].Oc1ccc(Cl)cc1.[Cu].[K+].[K+]>>O=C(O)Cc1ccccc1Oc1ccc(Cl)cc1",
        "output": "299"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN(Cc1ccccc1)c1cccc(C(=O)O)c1C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(C)c(CN)c(=O)[nH]1.F[P-](F)(F)(F)(F)F.O>>CCN(Cc1ccccc1)c1cccc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCNCC.CN(C)C=O.COc1ccc2c(=O)c3ccc(C(=O)O)cc3oc2c1>>CCN(CC)C(=O)c1ccc2c(=O)c3ccc(OC)cc3oc2c1",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)C(CC[N+](=O)[O-])c1cccc(Br)c1.[BH4-].[Na+]>>COC(=O)C(CCN)c1cccc(Br)c1",
        "output": "226"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.O=C1S/C(=C\\c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)C(=O)N1[C@H]1CCNC1>>CN1CC[C@H](N2C(=O)S/C(=C\\c3ccc4c(cnn4Cc4ccc(Cl)cc4C(F)(F)F)c3)C2=O)C1",
        "output": "217"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.ClCCCBr.ClCCl>>CC(C)(C)OC(=O)N1CCN(CCCCl)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)SCC1(C(=O)O)CCc2ccccc2C1.CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.Cc1ccc(S(=O)(=O)O)cc1.Cl.NCC(O)C(=O)OCc1ccccc1>>CC(=O)SCC1(C(=O)NCC(O)C(=O)OCc2ccccc2)CCc2ccccc2C1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](N)CC1.COc1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)O)c[nH]c23)c1>>COc1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)N[C@@H]4CC[C@@H](NC(=O)OC(C)(C)C)CC4)c[nH]c23)c1",
        "output": "737"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CCN(CC)CC.CN(C)C=O.Cl.O=C1OCc2cc(CCBr)ccc21.[I-].c1c2c(cc3nonc13)CC(N1CCNCC1)CC2>>O=C1OCc2cc(CCN3CCN(C4CCc5cc6nonc6cc5C4)CC3)ccc21",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.Nc1ccc(CCn2c3c(c(=O)[nH]c2=O)CCCC3)cc1.O.O=S(=O)(Cl)c1cccs1.c1ccncc1>>O=c1[nH]c(=O)n(CCc2ccc(NS(=O)(=O)c3cccs3)cc2)c2c1CCCC2",
        "output": "861"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(c1oc(=O)c2ccccc2c1-c1ccccc1)n1nc(-c2cc(F)cc(O[Si](C)(C)C(C)(C)C)c2)c2c(N)ncnc21.CCO.Cl>>CC(c1oc(=O)c2ccccc2c1-c1ccccc1)n1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc21",
        "output": "754"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.NOCC(=O)O.O.O=C1CCCc2cc(OCCn3ccnc3)ccc21.c1ccncc1>>O=C(O)CON=C1CCCc2cc(OCCn3ccnc3)ccc21",
        "output": "212"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.COC(=O)CBr.O=C([O-])[O-].Oc1ccc(C2CC2)cc1.[I-].[K+].[Na+].[Na+]>>COC(=O)COc1ccc(C2CC2)cc1",
        "output": "557"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CN(CCc1ccccc1OCc1ccccc1)C(=O)OC(C)(C)C.[Pd]>>CN(CCc1ccccc1O)C(=O)OC(C)(C)C",
        "output": "23"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].Cl.NO.O.O=C1CCCN(Cc2ccccc2)CC1.[Na+].[Na+].[OH-]>>ON=C1CCCN(Cc2ccccc2)CC1",
        "output": "86"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O.O=C(O)CN(CC(=O)O)Cc1ccc([N+](=O)[O-])cc1.[Na+].[OH-].[Pd]>>Nc1ccc(CN(CC(=O)O)CC(=O)O)cc1",
        "output": "507"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)c1cc([N+](=O)[O-])c(Cl)c([N+](=O)[O-])c1.CCCNCCC.c1ccccc1>>CCCN(CCC)c1c([N+](=O)[O-])cc(C(C)=O)cc1[N+](=O)[O-]",
        "output": "105"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)c1ccc(-c2cccc(-n3ncc4cc(C(C)(C)C)ccc4c3=O)c2COC(C)=O)n1C.N>>COC(=O)c1ccc(-c2cccc(-n3ncc4cc(C(C)(C)C)ccc4c3=O)c2CO)n1C",
        "output": "497"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cc(-c2cnn(C)c2)n(-c2cccnc2)n1.O.O.[Li+].[OH-]>>Cn1cc(-c2cc(C(=O)O)nn2-c2cccnc2)cn1",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.COc1ncc(C)cc1Br.ClCCl.O.O=C1CCC(=O)N1Br>>COc1ncc(CBr)cc1Br",
        "output": "625"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[C@@H]1CC[C@@H](Oc2ccc3cc(CNCC#N)ccc3c2)CC1.CC(C)O.O.O=C([O-])O.[Br-].[Br-].[N-]=[N+]=[N-].[Na+].[Na+].[Zn+2]>>CC(C)(C)[C@@H]1CC[C@@H](Oc2ccc3cc(CNCc4nnn[nH]4)ccc3c2)CC1",
        "output": "366"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)Oc1ccc(F)cc1Br.O=S(=O)(O)O.O=[N+]([O-])O>>COC(=O)Oc1cc([N+](=O)[O-])c(F)cc1Br",
        "output": "21"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)Cc1nc(-c2ccccc2)ncc1C(=O)O.Cl.O.[NH4+].[OH-]>>NC(=O)Cc1nc(-c2ccccc2)ncc1C(=O)O",
        "output": "432"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)CC(C)C.CCCCCCC.CCN(CC)CC.CCOC(=O)[C@@H]1CCCNC1.CCOC(C)=O.CS(=O)(=O)Cl.Cc1ccccc1.O.O=C(O)C(O)C(O)C(=O)O.O=C([O-])[O-].OCCOCCN1Cc2ccccc2Cc2ccccc21.[K+].[K+]>>CCOC(=O)[C@@H]1CCCN(CCOCCN2Cc3ccccc3Cc3ccccc32)C1",
        "output": "371"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(Cl)C(Cl)(Cl)Cl.Oc1ccc(Cl)cc1>>O=C(Oc1ccc(Cl)cc1)C(Cl)(Cl)Cl",
        "output": "111"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=C1CC[C@H]2[C@H](CCN)[C@@H]([C@@]3(C)CC[C@H](O)C[C@@H]3O)CC[C@]12C.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O=C(O)c1ccc2c(c1)OCO2>>C=C1CC[C@H]2[C@H](CCNC(=O)c3ccc4c(c3)OCO4)[C@@H]([C@@]3(C)CC[C@H](O)C[C@@H]3O)CC[C@]12C",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCCCc1ccc(C(=O)O)nc1.CCN(CC)CC.C[n+]1ccccc1Cl.Cl.Cl.N[C@@H]1CN2CCC1CC2.O.[I-]>>CCCCc1ccc(C(=O)N[C@@H]2CN3CCC2CC3)nc1",
        "output": "137"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)CCn1c(=O)c(=O)n(-c2ccccc2)c2cnc(Cl)nc21.C[C@@H]1C(=O)N(c2ccccc2)c2cnc(Cl)nc2N1C1CCCCC1.NC1CCCC1.Nc1ccc2[nH]ncc2c1>>CC(C)CCn1c(=O)c(=O)n(-c2ccccc2)c2cnc(Nc3ccc4[nH]ncc4c3)nc21",
        "output": "592"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.NC1CCN(c2nccc(-c3c[nH]c4ncccc34)n2)CC1.O.c1ccncc1>>CC(=O)NC1CCN(c2nccc(-c3c[nH]c4ncccc34)n2)CC1",
        "output": "339"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1cc(F)c(F)c(OCC(=O)OC(C)(C)C)c1F.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1cc(F)c(F)c(OCC(=O)O)c1F",
        "output": "278"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CCON.CC(C)C(=O)N1CCN([C@@H](CNC(=O)OC(C)(C)C)C(=O)O)CC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[B-](F)(F)F.O=C([O-])O.[Na+]>>C=CCONC(=O)[C@H](CNC(=O)OC(C)(C)C)N1CCN(C(=O)C(C)C)CC1",
        "output": "480"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCNCC.CN(C)C=O.COC(=O)c1ccc2nc(-c3ccccc3)c(Br)nc2c1>>CCN(CC)c1nc2cc(C(=O)OC)ccc2nc1-c1ccccc1",
        "output": "211"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1nc(-c2cnc3c(n2)c(C(=O)N[C@@H](C(=O)N2CC(C#N)C2)C2CC2)cn3COCC[Si](C)(C)C)cn1-c1ccccc1.ClCCl.O=C(O)C(F)(F)F>>Cc1nc(-c2cnc3[nH]cc(C(=O)N[C@@H](C(=O)N4CC(C#N)C4)C4CC4)c3n2)cn1-c1ccccc1",
        "output": "981"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C(=O)O)c1ccccc1.ClC(Cl)(Cl)Cl.O=S(Cl)Cl>>CC(C(=O)Cl)c1ccccc1",
        "output": "53"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCN(c2cccc(N)c2)CC1.CS(=O)(=O)c1ccc(Oc2cccn3nc(Cl)nc23)cc1>>CN1CCN(c2cccc(Nc3nc4c(Oc5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1",
        "output": "990"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(CCN)c1cc(Cl)c(N)c(Cl)c1.COc1cc2c(cc1OC)CC(=O)N(CCCCl)CC2>>COc1cc2c(cc1OC)CC(=O)N(CCCNCCN(C)c1cc(Cl)c(N)c(Cl)c1)CC2",
        "output": "279"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.O=C1CCc2cc(-c3ccc(C(F)(F)F)c([N+](=O)[O-])c3)ccc2N1.[Zn]>>Nc1cc(-c2ccc3c(c2)CCC(=O)N3)ccc1C(F)(F)F",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.O.O=C(Cl)OC1CCCCC1.O=Cc1ccccc1O>>O=Cc1ccccc1OC(=O)OC1CCCCC1",
        "output": "261"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCCCC1.CN(C)C=O.CN(C)CCN(C)C.Cl.Sc1ccc(Cl)cc1.[Li]CCCC>>O=Cc1cc(Cl)ccc1S",
        "output": "239"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)OC(=O)Cl.CCN(CC)CC.ClCCl.O=C([O-])O.O=C1CO[C@H]2CCCC[C@@H]2N1C1CCN(C2CCNCC2)CC1.[Na+]>>CC(C)OC(=O)N1CCC(N2CCC(N3C(=O)CO[C@H]4CCCC[C@@H]43)CC2)CC1",
        "output": "219"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CN(Cc1cccc(-c2ccc(C=C3SC(=O)NC3=O)cc2)c1)C(=O)OC(C)(C)C>>CN(Cc1cccc(-c2ccc(CC3SC(=O)NC3=O)cc2)c1)C(=O)OC(C)(C)C",
        "output": "762"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCCCCC(=O)/C=C/C1CCCC(=O)N1CC#CCCCC(=O)OC.O=P([O-])([O-])[O-]>>CCCCCC(=O)/C=C/C1CCCC(=O)N1CC#CCCCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCNS(=O)(=O)N1CCC(C#N)(CC2CC2)CC1.CCO.CCO.O.[Na+].[OH-]>>CCNS(=O)(=O)N1CCC(CN)(CC2CC2)CC1",
        "output": "246"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cc1ccc(C(=O)O)c(C)c1.O=S(=O)(O)O.[Ca+2].[OH-].[OH-]>>CCOC(=O)c1ccc(C)cc1C",
        "output": "33"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.O.OCc1cc(Br)co1.[H-].[Na+]>>COCc1cc(Br)co1",
        "output": "140"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1nc(C)c2c(-c3ccccc3)noc2c1O.CC[O-].CN(C)C=O.Cl.NCC(=O)O.O.[Na+]>>Cc1nc(C(=O)NCC(=O)O)c(O)c2onc(-c3ccccc3)c12",
        "output": "977"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Clc1nccc2ccccc12.O=S(=O)(O)O.O=[N+]([O-])O.O=[N+]([O-])[O-].[K+]>>O=[N+]([O-])c1cccc2c(Cl)nccc12",
        "output": "103"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCCCCCOc1ccc(C(=O)O)cc1.CCCCOCC(F)(F)C(F)(F)C(F)(F)COc1ccc(O)cc1.CN(C)c1ccncc1.ClCCl>>CCCCCCCCCCOc1ccc(C(=O)Oc2ccc(OCC(F)(F)C(F)(F)C(F)(F)COCCCC)cc2)cc1",
        "output": "355"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H]1CN=[N+]=[N-].CO.[H][H].[Pd]>>CC(C)(C)OC(=O)N1CC[C@@H]1CN",
        "output": "89"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)Cn1c(=O)oc2cc(N)ccc21.CS(=O)(=O)Cl.c1ccncc1>>COC(=O)Cn1c(=O)oc2cc(NS(C)(=O)=O)ccc21",
        "output": "194"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccccc1.O.O=C1Nc2ccc(O)cc2C1=Cc1c[nH]c2ncccc12.OCC(O)CCl>>O=C1Nc2ccc(OCC(O)CO)cc2C1=Cc1c[nH]c2ncccc12",
        "output": "74"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCC1(S(=O)(=O)Cl)CC1.Nc1c(F)cc(F)c(F)c1Nc1ccc(I)cc1F>>C=CCC1(S(=O)(=O)Nc2c(F)cc(F)c(F)c2Nc2ccc(I)cc2F)CC1",
        "output": "194"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1cnc2cc(Cl)cc(Cl)c2c1O.O=C([O-])[O-].O=C([O-])[O-].[K+].[K+].[K+].[Na+].[Na+].[Na+].[OH-].[OH-]>>O=C(O)c1cnc2cc(Cl)cc(Cl)c2c1O",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.N#Cc1ccc(Cl)nc1.O=C([O-])O.OCCN1CCOCC1.[H-].[Na+].[Na+]>>N#Cc1ccc(OCCN2CCOCC2)nc1",
        "output": "433"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CN2CCN1CC2.CC(C)=O.NCC(O)CC(=O)O.O.O=S(=O)(Cl)c1ccc(N2CCCCCC2)cc1>>O=C(O)CC(O)CNS(=O)(=O)c1ccc(N2CCCCCC2)cc1",
        "output": "43"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CC#N.O=[N+]([O-])c1cccc(F)c1>>O=[N+]([O-])c1cccc(N2CCOCC2)c1",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1nccs1.CC(C)(C)OC(=O)N1CC2CNCC2C1.CCCCO>>CC(C)(C)OC(=O)N1CC2CN(c3nccs3)CC2C1",
        "output": "657"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)N[C@@H]1CCc2cccc(N3CCNCC3)c2C1.CC(C)=O.CCBr.CCCCCC.CCOC(C)=O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CCN1CCN(c2cccc3c2C[C@H](NC(C)=O)CC3)CC1",
        "output": "73"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COC(=O)c1cccc(Oc2ccc(Cl)cc2N)c1.Cc1ccc2c(Cl)ccnc2n1>>COC(=O)c1cccc(Oc2ccc(Cl)cc2Nc2ccnc3nc(C)ccc23)c1",
        "output": "922"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.CNCCO.Nc1cc(Cl)ccc1[N+](=O)[O-].O.O=C([O-])[O-].[K+].[K+]>>CN(CCO)c1ccc([N+](=O)[O-])c(N)c1",
        "output": "105"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(O)CC(O)(C(F)(F)F)C(F)(F)F.O=C(Cl)C1CC2C=CC1C2.[CH2-]CCC.[Li+]>>CC(CC(O)(C(F)(F)F)C(F)(F)F)OC(=O)C1CC2C=CC1C2",
        "output": "126"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc(C2(C(F)(F)F)C=NC(c3ccccc3)C2)ccc1NC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>Cc1cc(C2(C(F)(F)F)C=NC(c3ccccc3)C2)ccc1N",
        "output": "782"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccccc1CC(C)=O.NCC(O)c1cccc(Cl)c1>>COc1ccccc1CC(C)NCC(O)c1cccc(Cl)c1",
        "output": "236"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)O/N=C(\\C(=O)O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1.CCOC(C)=O.ClCCl.ClP(Cl)(Cl)(Cl)Cl.NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(CCl)CS[C@H]12>>CC(C)O/N=C(\\C(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(CCl)CS[C@H]12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1",
        "output": "587"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CCCN1.Cc1nc2ccc(Br)cc2c(-c2ccccc2)c1C(=O)C(F)(F)F>>Cc1nc2ccc(N3CCCC3C)cc2c(-c2ccccc2)c1C(=O)C(F)(F)F",
        "output": "294"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=C(O)c1ccc(O)c(F)c1F.O=S(Cl)Cl>>COC(=O)c1ccc(O)c(F)c1F",
        "output": "33"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.N#CC(C#N)(CCC1CCC2(CC1)OCCO2)CCC(F)(F)F.O>>N#CC(C#N)(CCC1CCC(=O)CC1)CCC(F)(F)F",
        "output": "251"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1=COCCC1.CCCCCC.OCCCCl>>ClCCCOC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.COc1cc(OC)nc(Oc2cccc(Cl)c2C(=O)O)n1.ClCCl.O=[N+]([O-])c1ccc(O)cc1>>COc1cc(OC)nc(Oc2cccc(Cl)c2C(=O)Oc2ccc([N+](=O)[O-])cc2)n1",
        "output": "355"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=CC1(c2ccccc2)CCC=CCC1.[BH4-].[Na+]>>OCC1(c2ccccc2)CCC=CCC1",
        "output": "223"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COc1ccc(-c2ccc(C(=O)OCc3ccccc3)nc2C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C.[Pd]>>COc1ccc(-c2ccc(C(=O)O)nc2C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C",
        "output": "291"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CC(=O)[O-].NCc1ccc(C(=O)O)cc1.O.[Na+]>>CC(=O)NCc1ccc(C(=O)O)cc1",
        "output": "599"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.Cc1cc(O)cc(C)c1Cl.ClCCl.O=C(O)C(F)(F)F.OCCCc1c[nH]c2c(Br)cccc12.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(OCCCc2c[nH]c3c(Br)cccc23)cc(C)c1Cl",
        "output": "478"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCOC)cc1CC2C1(C)CC1.CO.Cl.[Li+].[OH-]>>COCCOc1cc2c(cc1OC)-c1cc(=O)c(C(=O)O)cn1C(C1(C)CC1)C2",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)C1(CS(=O)(=O)N2CCC(Oc3ccc(C(F)(F)F)cc3)CC2)CCOCC1.O.O.[Li+].[OH-]>>O=C(O)C1(CS(=O)(=O)N2CCC(Oc3ccc(C(F)(F)F)cc3)CC2)CCOCC1",
        "output": "361"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.NCc1ccccc1N.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)NCc1ccccc1N",
        "output": "686"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C(O)C(F)(F)F.O=c1c2cc(F)c(N3CCCC3)cc2n(-c2ccc(O)cc2)c(=O)n1OCc1ccccc1>>O=c1c2cc(F)c(N3CCCC3)cc2n(-c2ccc(O)cc2)c(=O)n1O",
        "output": "630"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.N.N#CCCCCCCCCC(=O)O.[Rh]>>NCCCCCCCCCC(=O)O",
        "output": "246"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.OCCCl.Oc1ccc(S)cc1.[K+].[OH-]>>OCCSc1ccc(O)cc1",
        "output": "460"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C)=O.O=C(C1CCOCC1)N1CCC(c2ccc(O)cc2)CC1.O=C([O-])[O-].OCCCCl.[K+].[K+]>>O=C(C1CCOCC1)N1CCC(c2ccc(OCCCO)cc2)CC1",
        "output": "74"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)c1sc(-c2ccc(Oc3ccccc3)cc2)cc1N(CC(=O)N1CCOCC1)C(=O)c1ccc(Cl)cc1Cl.Cl.O.O.[Li]O>>O=C(O)c1sc(-c2ccc(Oc3ccccc3)cc2)cc1N(CC(=O)N1CCOCC1)C(=O)c1ccc(Cl)cc1Cl",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CS(=O)(=O)c1ccc(F)c(Br)c1.NC1CCCCC1>>CS(=O)(=O)c1ccc(NC2CCCCC2)c(Br)c1",
        "output": "572"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Clc1ccccc1.O=C(Cl)c1cccc([N+](=O)[O-])c1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(c1ccc(Cl)cc1)c1cccc([N+](=O)[O-])c1",
        "output": "61"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "N.O=[N+]([O-])c1cnc(Cl)nc1NCCO>>Nc1ncc([N+](=O)[O-])c(NCCO)n1",
        "output": "312"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCN(CCC)C1CCc2cccc(C=O)c2C1.CCO.Cl.O.[BH4-].[Na+]>>CCCN(CCC)C1CCc2cccc(CO)c2C1",
        "output": "356"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N1CCN(c2ccc(N)nc2)CC1.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(-c2ccc(CC(=O)O)cc2C#N)ccn1.F[P-](F)(F)(F)(F)F.O>>CC(=O)N1CCN(c2ccc(NC(=O)Cc3ccc(-c4ccnc(C)c4)c(C#N)c3)nc2)CC1",
        "output": "368"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CCI.O=C([O-])[O-].O=Cc1c(O)ccc2ccccc12.[K+].[K+]>>CCOc1ccc2ccccc2c1C=O",
        "output": "198"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Nc1nc(-c2ccc(-c3ccccc3)cc2)c(Cl)cc1[N+](=O)[O-].O.[Cl-].[Fe].[NH4+]>>Nc1cc(Cl)c(-c2ccc(-c3ccccc3)cc2)nc1N",
        "output": "269"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.C[C@H](N)[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1.O=Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>C[C@H](NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1",
        "output": "468"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN1CCN(CCCN)CC1.O=Cc1cc(-c2ccc3c(c2)OCO3)n(S(=O)(=O)c2cccc(Cl)c2)c1.[Na+]>>CN1CCN(CCCNCc2cc(-c3ccc4c(c3)OCO4)n(S(=O)(=O)c3cccc(Cl)c3)c2)CC1",
        "output": "441"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCCc1c(OCCF)ccc2cc(C(=O)Nc3ccc(CN(C)C(=O)OC(C)(C)C)cc3)c(=O)oc12.Cl>>CCCc1c(OCCF)ccc2cc(C(=O)Nc3ccc(CNC)cc3)c(=O)oc12",
        "output": "887"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.COC(=O)c1cc(F)c(CN)nc1Nc1ccc([Si](C)(C)C)cc1F.O=CO>>COC(=O)c1cc(F)c(CNC=O)nc1Nc1ccc([Si](C)(C)C)cc1F",
        "output": "370"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)[C@@H](Oc1nc(C)cc(CO)n1)C(OC)(c1ccccc1)c1ccccc1.O.[Na+].[OH-]>>COC(c1ccccc1)(c1ccccc1)[C@H](Oc1nc(C)cc(CO)n1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CO1.CCC1(C)CC(NC(=O)c2ccccc2)C(C)C(C)(CC)N1.CO.Cl>>CCC1(C)CC(NC(=O)c2ccccc2)C(C)C(C)(CC)N1CCO",
        "output": "76"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(C=O)c(C)c1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.Nc1ccc(Cl)cc1Cl>>Cc1ccc(C=Nc2ccc(Cl)cc2Cl)c(C)c1",
        "output": "329"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.COc1c(C)cnc(Cn2nc(CC(O)C#N)c3c(Cl)nc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nc32)c1C.Cc1ccc(S(=O)(=O)Cl)cc1.ClC(Cl)Cl.ClCCl>>COc1c(C)cnc(Cn2nc(CC(C#N)OS(=O)(=O)c3ccc(C)cc3)c3c(Cl)nc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nc32)c1C",
        "output": "197"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1cccc2c1cc(C(=O)OC(C)(C)C)n2Cc1cc(-c2ccc(Cl)s2)on1.Cc1ccccc1.O=C(O)C(F)(F)F>>COC(=O)c1cccc2c1cc(C(=O)O)n2Cc1cc(-c2ccc(Cl)s2)on1",
        "output": "569"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCN1C(=O)C(O)(c2cc(Br)ccc2O)c2ccccc21.CCCCCN1C(=O)C(O)(c2cc(Cl)c(Cl)cc2O)c2ccccc21>>CCCCCN1C(=O)C(c2cc(Cl)c(Cl)cc2O)c2ccccc21",
        "output": "964"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.Cc1ccnc(N2CCN(CCc3c(C)n4c5c(cc(N)cc35)CCC4)CC2)c1.ClC(Cl)Cl.O=C(Cl)c1ccccc1>>Cc1ccnc(N2CCN(CCc3c(C)n4c5c(cc(NC(=O)c6ccccc6)cc35)CCC4)CC2)c1",
        "output": "11"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1nc2ccc(C(O)C3CCN(C(=O)OC(C)(C)C)CC3)cc2c(Cl)c1Cc1ccc(C(F)(F)F)cc1.ClCCl.O=C(O)C(F)(F)F.[Na+].[OH-]>>COc1nc2ccc(C(O)C3CCNCC3)cc2c(Cl)c1Cc1ccc(C(F)(F)F)cc1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.Cc1cc(O)ccc1Cl.O.O=S(=O)(O)O>>CC(=O)Oc1ccc(Cl)c(C)c1",
        "output": "46"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1nnc(-c2cn(COCC[Si](C)(C)C)c3ncnc(-c4cccc([N+](=O)[O-])c4)c23)s1>>Cc1nnc(-c2cn(COCC[Si](C)(C)C)c3ncnc(-c4cccc(N)c4)c23)s1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CN1CCN(c2nn(C3CCOCC3)c3c2CNCC3)c2cc(C#N)c(-c3cnn(C)c3)cc21.ClCCl>>CC(=O)N1CCc2c(c(N3CCN(C)c4cc(-c5cnn(C)c5)c(C#N)cc43)nn2C2CCOCC2)C1",
        "output": "369"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc2c(cc1OC)C(=O)CCO2.Cl.ClCCl.c1ccncc1>>O=C1CCOc2cc(O)c(O)cc21",
        "output": "19"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(C)=O.CCCCCCCCCCCCCCBr.COC(=O)c1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>CCCCCCCCCCCCCCOc1ccc(C(=O)OC)cc1",
        "output": "385"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)CCN.CCN(C(C)C)C(C)C.CCc1cc(-c2noc(-c3cc(C)nc(N(C)C(C)C)c3)n2)cc(C)c1CCC(=O)O.CN(C)C=O.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CCc1cc(-c2noc(-c3cc(C)nc(N(C)C(C)C)c3)n2)cc(C)c1CCC(=O)NCCC(=O)OC(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.Cc1cccnc1[C@@H]1CCC[C@H](c2ncccc2C)N1.N#Cc1ccc(CBr)cc1F>>Cc1cccnc1[C@@H]1CCC[C@H](c2ncccc2C)N1Cc1ccc(C#N)c(F)c1",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(C)=O.Clc1ccc(Cl)nc1.O=C(CN1CCNCC1)NC1C2CC3CC(C2)CC1C3.O=C([O-])[O-].[Na+].[Na+]>>O=C(CN1CCN(c2ccc(Cl)cn2)CC1)NC1C2CC3CC(C2)CC1C3",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C(=O)O)c1cn2nc(Cl)ccc2n1.CCN(CC)CC.CN(C)C=O.CNC.Cl>>CN(C)C(=O)C(C)(C)c1cn2nc(Cl)ccc2n1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COCCOC.Cn1ncc(Br)c1Nc1ccc(I)cc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].OB(O)c1ccc(Cl)cc1.[Cs+].[Cs+].[Pd].[Pd]>>Cn1ncc(Br)c1Nc1ccc(-c2ccc(Cl)cc2)cc1",
        "output": "855"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.C[C@H](N)C1CCC1.O=Cc1ccccc1.[Na+]>>C[C@H](NCc1ccccc1)C1CCC1",
        "output": "468"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.ClCCl.O=C(CN1CCc2c([nH]c3ccccc23)C1c1ccccc1)OCc1ccccc1.[H][H].[Pd]>>O=C(O)CN1CCc2c([nH]c3ccccc23)C1c1ccccc1",
        "output": "186"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.N#Cc1ccc(Cc2cnn(-c3ccc(OC(F)(F)F)cc3)c2C2CCCCC2)cc1.O.[K+].[OH-]>>O=C(O)c1ccc(Cc2cnn(-c3ccc(OC(F)(F)F)cc3)c2C2CCCCC2)cc1",
        "output": "445"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCC(=O)O.CCN(C(C)C)C(C)C.CN(C)C=O.NC[C@H]1CN(c2ccc(C3=NNC(=O)CS3)c(F)c2)C(=O)O1>>CCC(=O)NC[C@H]1CN(c2ccc(C3=NNC(=O)CS3)c(F)c2)C(=O)O1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CC(C)(C)c1cc[nH]n1.CN(C)C=O.O.[H-].[Na+]>>CC(C)(C)c1ccn(Cc2ccccc2)n1",
        "output": "635"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCOC(C)=O.CCOCC.COc1ccc(C(=O)Nc2ncccc2NC(=O)OC(C)(C)C)cc1.FB(F)F.O=C([O-])O.[Na+]>>COc1ccc(C(=O)Nc2ncccc2N)cc1",
        "output": "877"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCC.CCOC(C)=O.O=C(O)C(F)(F)F.O=C(O)CCSc1cccc(Cl)c1Cl.O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C([O-])[O-].[Na+].[Na+]>>O=C1CCSc2c1ccc(Cl)c2Cl",
        "output": "274"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNC1.Cc1oc(-c2ccccc2)nc1CCNC(=O)c1c(C(=O)O)cnn1C>>Cc1oc(-c2ccccc2)nc1CCNC(=O)c1c(C(=O)N2CCCC2)cnn1C",
        "output": "733"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cc(-c2ncc(F)c3c(C(=O)C(=O)N4CCN(c5nnnn5-c5ccccc5)CC4)c[nH]c23)n[nH]1.CN(C)C=O.Cl.O.O.[Li+].[OH-]>>O=C(O)c1cc(-c2ncc(F)c3c(C(=O)C(=O)N4CCN(c5nnnn5-c5ccccc5)CC4)c[nH]c23)n[nH]1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O=C(CCCCC(=O)N1C[C@H](CO)[C@@H](c2cccc(C(F)(F)F)c2)C1)OCc1ccccc1.O=C(Cl)C(=O)Cl>>O=C[C@H]1CN(C(=O)CCCCC(=O)OCc2ccccc2)C[C@@H]1c1cccc(C(F)(F)F)c1",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.C[C@H](CCCO)[C@H]1CC[C@H]2[C@@H]3[C@H](OCc4ccccc4)C[C@H]4C[C@@H](OC5CCCCO5)CC[C@]4(C)[C@H]3CC[C@]12C.ClCCl.O=C(Cl)C(=O)Cl.O=C([O-])O.[Na+]>>C[C@H](CCC=O)[C@H]1CC[C@H]2[C@@H]3[C@H](OCc4ccccc4)C[C@H]4C[C@@H](OC5CCCCO5)CC[C@]4(C)[C@H]3CC[C@]12C",
        "output": "142"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.O=C(OC(=O)C(F)(F)F)C(F)(F)F.OCCN1CCNCC1>>O=C(N1CCN(CCO)CC1)C(F)(F)F",
        "output": "397"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)Cc1csc(N)n1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)c1ccncc1.CN1CCOCC1.Cc1cc(C)cc(S(=O)(=O)N2CCc3ccc(C(=O)O)cc32)c1.F[P-](F)(F)(F)(F)F>>CCOC(=O)Cc1csc(NC(=O)c2ccc3c(c2)N(S(=O)(=O)c2cc(C)cc(C)c2)CC3)n1",
        "output": "918"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.OCC1CCOCC1>>Cc1ccc(S(=O)(=O)OCC2CCOCC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(CO[Si](C)(C)C(C)(C)C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(C#N)cc3)c2)c2cncnc21.Cl.ClCCl.[Na+].[OH-]>>CC(C)(CO)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(C#N)cc3)c2)c2cncnc21",
        "output": "708"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.Cn1cc2c(-c3ccc(Cl)nc3)c(-c3ccncc3)c(-c3ccc(F)cc3)nc2n1.[Zn]>>Cn1cc2c(-c3cccnc3)c(-c3ccncc3)c(-c3ccc(F)cc3)nc2n1",
        "output": "40"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CC=C(c2cc(=O)[nH]c3ccc(C(c4ccc(Cl)cc4)c4ccc(Cl)cc4)cc23)CC1.ClCCl.O=C(O)C(F)(F)F>>O=c1cc(C2=CCNCC2)c2cc(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)ccc2[nH]1",
        "output": "800"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[O-].CC(Oc1nncc2cc(Br)ccc12)C(F)(F)F.CO.Cc1ccccc1.Nc1ccc(F)cc1F.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(-c2ccccc2P(C2CCCCC2)C2CCCCC2)cc1>>CC(Oc1nncc2cc(Nc3ccc(F)cc3F)ccc12)C(F)(F)F",
        "output": "405"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F.NC(=O)CC(N)C1CCOC1.O=C(O)c1ccc(C2CC2)c(OCC2CC2)n1>>NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CCOC1",
        "output": "137"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc2nccc(Cl)c2cc1OC.Cc1ccc(C(=O)c2ccc(O)cc2)cc1>>COc1cc2nccc(Oc3ccc(C(=O)c4ccc(C)cc4)cc3)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1cc(C)c(-c2cccc(C=O)c2)c(C)c1.O=C(O)CC(O)(CC(=O)O)C(=O)O.[BH4-].[Na+]>>Cc1cc(C)c(-c2cccc(CO)c2)c(C)c1",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)CN.CCOCC.O=C=NCCCl>>CC(C)(C)CNC(=O)NCCCl",
        "output": "244"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C1CNCCC1=O.CN(C)C=O.ClCCl.O.O=C(Cl)C(=O)Cl.O=C(O)COc1ccccc1>>CCOC(=O)C1CN(C(=O)COc2ccccc2)CCC1=O",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)N(C)C.CC(C)(C)OC(=O)NCC1(C(=O)O)CCN(c2ncnc3[nH]ccc23)CC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CS(=O)(=O)c1ccc2nc(N)sc2c1.F[P-](F)(F)(F)(F)F>>CC(C)(C)OC(=O)NCC1(C(=O)Nc2nc3ccc(S(C)(=O)=O)cc3s2)CCN(c2ncnc3[nH]ccc23)CC1",
        "output": "681"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.O.O=C(NC(=S)Nc1ccc2c(c1)C(=O)Nc1ccccc1N2)c1ccccc1.[Na+].[OH-]>>NC(=S)Nc1ccc2c(c1)C(=O)Nc1ccccc1N2",
        "output": "80"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COCCl.Oc1c(Br)cccc1Br>>COCOc1c(Br)cccc1Br",
        "output": "375"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.CN(C)c1cc(C=O)ccc1O.COCCl.O.[H-].[Na+]>>COCOc1ccc(C=O)cc1N(C)C",
        "output": "375"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.CO.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O=C(Cc1ccccc1)N1CCC(Cn2ccc3cc(-c4cnn(C5CCCCO5)c4)ccc32)CC1>>O=C(Cc1ccccc1)N1CCC(Cn2ccc3cc(-c4cn[nH]c4)ccc32)CC1",
        "output": "689"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCNCC1.CS(=O)(=O)OCCc1ccc(Nc2ncc3c(n2)-c2ccccc2C(c2ccc(Cl)c(Cl)c2)C3)cc1>>CN1CCN(CCc2ccc(Nc3ncc4c(n3)-c3ccccc3C(c3ccc(Cl)c(Cl)c3)C4)cc2)CC1",
        "output": "496"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)Cc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12.CN>>CNC(=O)Cc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12",
        "output": "64"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COCOc1ccc2ncn(-c3cc(O[C@H](C)c4ccccc4C(F)(F)F)c(C(=O)OC)s3)c2c1.Cl.ClCCl.O.O=C([O-])O.[Na+]>>COC(=O)c1sc(-n2cnc3ccc(O)cc32)cc1O[C@H](C)c1ccccc1C(F)(F)F",
        "output": "755"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC#N.CN(C)c1ccncc1.FC(F)(F)c1cnc(Cl)c(Cl)c1.O.[C-]#N.[Na+]>>N#Cc1ncc(C(F)(F)F)cc1Cl",
        "output": "726"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(C)=O.ClCCl.N#Cc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(CC2CC2)CC[C@]314.O=C([O-])[O-].OO.[K+].[K+]>>NC(=O)c1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(CC2CC2)CC[C@]314",
        "output": "180"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN(c1cc(Br)c(F)c(C(=O)O)c1C)C1CCOCC1.CCOC(C)=O.CN(C)C=O.Cc1cc(C)c(CN)c(=O)[nH]1.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CCN(c1cc(Br)c(F)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.CNc1nc(CO)ccc1C.[H-].[Na+]>>CNc1nc(CO[Si](C)(C)C(C)(C)C)ccc1C",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ccc(Br)cc1F.[Br-].[Li]CCCC>>C=Cc1ccc(Br)cc1F",
        "output": "649"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCNCC1.CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Cc1cc(Br)cnc1Nc1ncc2c3ccncc3n(C3CCCC3)c2n1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Cl-].[NH4+].[Na+].[Pd].[Pd]>>Cc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)cnc1Nc1ncc2c3ccncc3n(C3CCCC3)c2n1",
        "output": "597"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC(=O)Cl.Cc1ccc(OCC2CC2)c(-c2nc(C)nc3c(C(=O)NC4CCNCC4)c(C)[nH]c23)c1.Cl>>CCC(=O)N1CCC(NC(=O)c2c(C)[nH]c3c(-c4cc(C)ccc4OCC4CC4)nc(C)nc23)CC1",
        "output": "125"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(C)(C)c1ccccc1O.O=C1CCC(=O)N1Br>>CC(C)(C)c1cc(Br)ccc1O",
        "output": "4"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(Nc1cnc2ccccc2c1)C(=O)O.CCCC[C@H](N)C(=O)OC.Cl>>CCCC[C@H](NC(=O)C(C)Nc1cnc2ccccc2c1)C(=O)OC",
        "output": "129"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cl.N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O.N[C@@H](Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1)C(=O)O.O=C([O-])O.[Na+]>>COC(=O)[C@@H](N)Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)[C@@H](N)CO.CO.C[C@H](NC(=O)Cc1cccc([N+](=O)[O-])c1)C(=O)O.Cl.ClC(Cl)Cl>>CCOC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)Cc1cccc([N+](=O)[O-])c1",
        "output": "107"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CNCCN1.CC1CCc2ccccc2C1Nc1cc(F)ccc1S(C)(=O)=O.CCN(C(C)C)C(C)C.CN(C)C=O.O>>CC1CCc2ccccc2C1Nc1cc(N2CCNCC2)ccc1S(C)(=O)=O",
        "output": "26"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CC#N.N#CC1(c2cccc(C(=O)Nc3cccc(Oc4ccc5nc(NC(=O)CCl)cn5n4)c3)c2)CC1>>N#CC1(c2cccc(C(=O)Nc3cccc(Oc4ccc5nc(NC(=O)CN6CCOCC6)cn5n4)c3)c2)CC1",
        "output": "340"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCN.Cc1ccc(S(=O)(=O)OCC2Cc3cc(F)cc(-c4c(Cl)cccc4Cl)c3O2)cc1>>CCCNCC1Cc2cc(F)cc(-c3c(Cl)cccc3Cl)c2O1",
        "output": "853"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCNC(C)C.O=C(Nc1ccc2[nH]ncc2c1)c1cc(Cl)ncn1>>CCCN(c1cc(C(=O)Nc2ccc3[nH]ncc3c2)ncn1)C(C)C",
        "output": "162"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cc1cccc(C)c1NC(=O)CN1CCN(CC(O)CNC(=O)OCc2ccccc2)CC1>>Cc1cccc(C)c1NC(=O)CN1CCN(CC(O)CN)CC1",
        "output": "574"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc2c(c1)S(=O)(=O)CCN(c1cc(Cl)c3cc(Cl)ccc3n1)C2.NCC1(CN)COC1>>COc1ccc2c(c1)S(=O)(=O)CCN(c1cc(NCC3(CN)COC3)c3cc(Cl)ccc3n1)C2",
        "output": "78"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Nc1ccc(Cl)c(NC(=O)c2ccccc2)c1.O=C(O)c1ccc(CBr)nc1>>O=C(Nc1ccc(Cl)c(NC(=O)c2ccccc2)c1)c1ccc(CBr)nc1",
        "output": "739"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.COc1cccc(F)c1C1CCN(c2cnnc(NN)c2Cl)CC1.O.O=C(Cl)CC(F)(F)F.O=C([O-])O.[Na+]>>COc1cccc(F)c1C1CCN(c2cnnc(NNC(=O)CC(F)(F)F)c2Cl)CC1",
        "output": "450"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC1CCN(c2cccc3ccc(-c4cnc5cc(-c6cccnc6)ccn45)nc23)CC1.CO.CO.ClC(Cl)Cl.ClC(Cl)Cl.ClCCl.O=C(O)C(F)(F)F>>NC1CCN(c2cccc3ccc(-c4cnc5cc(-c6cccnc6)ccn45)nc23)CC1",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCCl.ClCCl.NCc1ccc(Cl)c(Cl)c1.Nc1ccc([N+](=O)[O-])cc1C(=O)O.O.On1nnc2ccccc21.[Cl-].[NH4+]>>Nc1ccc([N+](=O)[O-])cc1C(=O)NCc1ccc(Cl)c(Cl)c1",
        "output": "753"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCc1ccccc1.C1CCOC1.CS(C)=O.O.Oc1ccc(C2(O)CCC3(CC2)OCCO3)nc1.[H-].[Na+]>>OC1(c2ccc(OCc3ccccc3)cn2)CCC2(CC1)OCCO2",
        "output": "623"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.Cl[Ru](Cl)Cl.Clc1ccccc1.O.O.O.O=Cc1ccccc1-c1ccc(C(F)(F)F)cc1.O=S(=O)(O)O.[Br-].[Na+].[O-]Cl>>O=C(O)c1ccccc1-c1ccc(C(F)(F)F)cc1",
        "output": "384"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CCOC(=O)c1ccc(Nc2nc(Cl)nc3[nH]cnc23)cc1.N[C@H]1CC[C@H](N)CC1>>CCN(CC)CCOC(=O)c1ccc(Nc2nc(N[C@@H]3CC[C@@H](N)CC3)nc3[nH]cnc23)cc1",
        "output": "544"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(CC)C(=O)Cl.Nc1ccc(N2CCC(C(c3ccccc3)c3ccccc3)CC2)c(F)c1>>CCC(CC)C(=O)Nc1ccc(N2CCC(C(c3ccccc3)c3ccccc3)CC2)c(F)c1",
        "output": "9"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.O=[N+]([O-])c1cc(C2CC2)ccc1F.[Fe]>>Nc1cc(C2CC2)ccc1F",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)/C=C(C)/C=C/C=C(/C)c1cc2c(cc1OC)OC(C)(C)C=C2C(C)C.[Na+].[OH-]>>COc1cc2c(cc1/C(C)=C\\C=C\\C(C)=C\\C(=O)O)C(C(C)C)=CC(C)(C)O2",
        "output": "122"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Brc1ccc2c3ccccc3n(-c3ccccn3)c2c1.O=C(O)[C@@H]1CCCN1.O=C([O-])[O-].[Cu]I.[K+].[K+].c1ccc2c(c1)[nH]c1cc(-n3cccn3)ccc12>>c1ccc(-n2c3ccccc3c3ccc(-n4c5ccccc5c5ccc(-n6cccn6)cc54)cc32)nc1",
        "output": "982"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1c(N2CCN(C(=O)C(Cl)(Cl)Cl)CC2)ccc2ccccc12.ClCCl.ClP(Cl)(Cl)(Cl)Cl.O=S(=O)(O)Cl>>COc1c(N2CCN(C(=O)C(Cl)(Cl)Cl)CC2)cc(S(=O)(=O)Cl)c2ccccc12",
        "output": "182"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCCCc1ccccc1.CCOC(=O)c1ccc(CCN2CCNCC2)cc1.CN(C)P(=O)(N(C)C)N(C)C>>CCOC(=O)c1ccc(CCN2CCN(CCCc3ccccc3)CC2)cc1",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCCC1c1cn(-c2ccc(Br)cc2)c(C(C)(C)c2ccccc2Cl)n1.CS(=O)(=O)c1cccc(B(O)O)c1.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCCC1c1cn(-c2ccc(-c3cccc(S(C)(=O)=O)c3)cc2)c(C(C)(C)c2ccccc2Cl)n1",
        "output": "837"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CI.CN(C)C=O.COc1ccc(C2CNC(=O)CO2)cc1OC.O.[H-].[Na+]>>COc1ccc(C2CN(C)C(=O)CO2)cc1OC",
        "output": "83"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.O=C(Cl)Oc1ccccc1.O=C(Nc1ccc(N2CCNCC2)nc1)c1nnc(Nc2ccccc2F)o1>>O=C(Nc1ccc(N2CCN(C(=O)Oc3ccccc3)CC2)nc1)c1nnc(Nc2ccccc2F)o1",
        "output": "219"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N1CCN(C2CNC2)CC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.CN(C[C@@H](CC=O)c1ccc(F)cc1)C(=O)c1cc(Cl)cc(C(F)(F)F)c1.CO.Cl.[Na+]>>CC(=O)N1CCN(C2CN(CC[C@H](CN(C)C(=O)c3cc(Cl)cc(C(F)(F)F)c3)c3ccc(F)cc3)C2)CC1",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOCCOc1ccc(COc2ccc3c(c2)C=C(C(=O)OC)CCS3(=O)=O)cc1.CO.O=C([O-])[O-].[K+].[K+]>>CCOCCOc1ccc(COc2ccc3c(c2)C=C(C(=O)O)CCS3(=O)=O)cc1",
        "output": "58"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.Fc1cncc2cn(-c3c(Cl)cc(Br)cc3Cl)nc12.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1cc(F)c2nn(-c3c(Cl)cc(Br)cc3Cl)cc2c1",
        "output": "262"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCCCCCCCCOc1ccc(C(=O)O)cc1OCCCCCCCCCCCCCC.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl>>CCCCCCCCCCCCCCOc1ccc(C(=O)Cl)cc1OCCCCCCCCCCCCCC",
        "output": "448"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.Cc1nnc2n1-c1ccccc1N(c1ccc(Cl)cc1)C(=O)C2>>Cc1nnc2n1-c1ccccc1N(c1ccc(Cl)cc1)CC2",
        "output": "112"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.O=C1c2ccccc2C(=O)N1CCCCBr.Oc1ccncc1>>O=C1c2ccccc2C(=O)N1CCCCOc1ccncc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCOC(C)=O.COc1ccc(CN2C(=O)[C@H](N)[C@@H]2c2ccccc2C2OCCO2)c(OC)c1.O=C(Cl)COc1ccccc1>>COc1ccc(CN2C(=O)[C@H](NC(=O)COc3ccccc3)[C@@H]2c2ccccc2C2OCCO2)c(OC)c1",
        "output": "159"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cl.O=C(O)Cc1ccc2nc(-c3ccccc3)oc2c1>>CCOC(=O)Cc1ccc2nc(-c3ccccc3)oc2c1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[C@H]1CN(C(=O)OC(C)(C)C)CCN1.O=[N+]([O-])c1ccc(Br)cn1>>C[C@H]1CN(C(=O)OC(C)(C)C)CCN1c1ccc([N+](=O)[O-])nc1",
        "output": "597"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)c1nn(CC(=O)O)c2cc(P(=O)(OCC)OCC)ccc12.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O=C(NCc1cccc(Cl)c1F)[C@@H]1C[C@@H](F)CN1>>CCOC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cc(P(=O)(OCC)OCC)ccc12",
        "output": "297"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1cccc(Oc2ccccc2)c1.CC(=O)/C=C(/C)[O-].CC(=O)/C=C(/C)[O-].CC(=O)/C=C(/C)[O-].CN1CCCC1=O.O=C([O-])[O-].Oc1cccc(-c2ccc(-n3c4ccccc4c4ccccc43)cc2)c1.[Cu]I.[Fe+3].[K+].[K+]>>c1ccc(Oc2cccc(Oc3cccc(-c4ccc(-n5c6ccccc6c6ccccc65)cc4)c3)c2)cc1",
        "output": "238"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COCCOC.Cl[Pd]Cl.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.N#N.Nc1ccc(Br)cc1[N+](=O)[O-].O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cn1cc(-c2ccc(N)c([N+](=O)[O-])c2)cn1",
        "output": "971"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.Cc1c(Br)cncc1[N+](=O)[O-].OO>>Cc1c(Br)c[n+]([O-])cc1[N+](=O)[O-]",
        "output": "396"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.COCCOC.Clc1ccc(Cl)nn1.O=C([O-])[O-].O=[N+]([O-])c1cccc(B(O)O)c1.[Na+].[Na+]>>O=[N+]([O-])c1cccc(-c2ccc(Cl)nn2)c1",
        "output": "866"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1c(C=CCCCCCCCCCC(=O)O)cccc1C(=O)c1ccc(Cl)cc1.[H][H].[Ni]>>Cc1c(CCCCCCCCCCCC(=O)O)cccc1C(=O)c1ccc(Cl)cc1",
        "output": "362"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCO.COc1cccc([N+](=O)[O-])c1Br.O.O=C([O-])[O-].[Fe].[Na+].[Na+]>>COc1cccc(N)c1Br",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1cc(Br)cc(Nc2nccc(C(F)F)n2)c1.ClCCl.ClCCl.Cl[Pd]Cl.O.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cc(Nc2nccc(C(F)F)n2)cc(B2OC(C)(C)C(C)(C)O2)c1",
        "output": "942"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(N2CCOCC2)c2cccnc12.[K+].[K+]>>Nc1ccc(N2CCOCC2)c2cccnc12",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC1(C)OCC(c2ccc3cc(Br)ccc3c2)([N+](=O)[O-])CO1.CN(C)CC(=O)O.Cl.Oc1ccc(Oc2ccccc2)cc1.[Cu]I>>CC1(C)OCC(c2ccc3cc(Oc4ccc(Oc5ccccc5)cc4)ccc3c2)([N+](=O)[O-])CO1",
        "output": "238"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.C[Si](C)(C)C#Cc1cnc(-c2ccccc2)nc1Nc1cc(C2CC2)[nH]n1.[Na+].[OH-]>>C#Cc1cnc(-c2ccccc2)nc1Nc1cc(C2CC2)[nH]n1",
        "output": "337"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCn1cc(C#N)c2ccc(Cl)cc21.CN1CCNCC1.COCCOC.ClCCl.Clc1ccc2cc[nH]c2c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd].c1ccc(-c2ccccc2P(C2CCCCC2)C2CCCCC2)cc1>>CCn1cc(C#N)c2ccc(N3CCN(C)CC3)cc21",
        "output": "280"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.ClC(Cl)Cl.ClCCl.O=C(Cl)OCc1ccccc1.O=C(O)CC(O)(CC(=O)O)C(=O)O.OC1CCCNC1>>O=C(OCc1ccccc1)N1CCCC(O)C1",
        "output": "427"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(C)(C)N.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cccc(C(=O)O)c3)cc12.F[P-](F)(F)(F)(F)F>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cccc(C(=O)NC(C)(C)C)c3)cc12",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CSc1ncc2cc(-c3ccc(-c4cncc(C)n4)cc3Cl)c(=O)n(CC3OCC(NC(=O)OC(C)(C)C)CO3)c2n1.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cc1cncc(-c2ccc(-c3cc4cnc(S(C)=O)nc4n(CC4OCC(NC(=O)OC(C)(C)C)CO4)c3=O)c(Cl)c2)n1",
        "output": "595"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CNc1nc(Cl)ncc1Cl.COc1cc(C(=O)N2CCOCC2)c(C(F)(F)F)cc1N.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O=C([O-])O.[Na+]>>CNc1nc(Nc2cc(C(F)(F)F)c(C(=O)N3CCOCC3)cc2OC)ncc1Cl",
        "output": "941"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN1[C@@H](C(=O)Nc2ccc(C(=O)OC)cc2)[C@H](c2cccc(Cl)c2F)[C@@](C#N)(c2ccc(Cl)cc2F)[C@@H]1CC(C)(C)C.CO.O.[Li+].[OH-]>>CCN1[C@@H](C(=O)Nc2ccc(C(=O)O)cc2)[C@H](c2cccc(Cl)c2F)[C@@](C#N)(c2ccc(Cl)cc2F)[C@@H]1CC(C)(C)C",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(CCN(C)C(=O)OC(C)(C)C)CC(=O)OCc1ccccc1.CO.[C].[Pd]>>CN(CCN(C)C(=O)OC(C)(C)C)CC(=O)O",
        "output": "186"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2c[nH]c3cc(N4CCOCC4)ncc23)CC1.ClCCl.O=C(O)C(F)(F)F>>c1[nH]c2cc(N3CCOCC3)ncc2c1C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(C)=O.Cc1cccc(N=C=O)c1.NC(=O)n1c(-c2cccc(N)c2)cc2ccccc21>>Cc1cccc(NC(=O)Nc2cccc(-c3cc4ccccc4n3C(N)=O)c2)c1",
        "output": "473"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)Cn1cncc1CCCc1ccccc1.Cl>>O=C(O)Cn1cncc1CCCc1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC1)CC(O)(c1ccc(F)c(Cl)c1)C2.CI.CN(C)C=O.[H-].[Na+]>>COC1(c2ccc(F)c(Cl)c2)CC2(CCN(C(=O)OC(C)(C)C)CC2)C1",
        "output": "140"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CO.O=C(NCCCN1CCC(C(=O)c2ccc(F)cc2)CC1)c1ccccc1[N+](=O)[O-].[H][H].[Pt].c1ccsc1>>Nc1ccccc1C(=O)NCCCN1CCC(C(=O)c2ccc(F)cc2)CC1",
        "output": "486"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(N)C(Cc1ccc(Cl)cc1)c1ccc(Cl)cc1.CCN(C(C)C)C(C)C.Cl.ClCCl.O=S(=O)(Cl)c1ccc2ccccc2c1>>CC(NS(=O)(=O)c1ccc2ccccc2c1)C(Cc1ccc(Cl)cc1)c1ccc(Cl)cc1",
        "output": "43"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cc(CN)no1.O=C(O)c1cc(-c2ccc(Cl)cc2)c(OCC(F)(F)F)cn1>>Cc1cc(CNC(=O)c2cc(-c3ccc(Cl)cc3)c(OCC(F)(F)F)cn2)no1",
        "output": "137"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CO.Cc1nnc(N2CCC(=O)CC2)o1.Cl.NOCc1ccccc1.[NH4+]>>Cc1nnc(N2CCC(=NOCc3ccccc3)CC2)o1",
        "output": "86"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.COc1ccc(F)c(Cl)c1.ClCCl.O=C1CCC(=O)N1I.O=S(=O)(O)O>>COc1cc(Cl)c(F)cc1I",
        "output": "834"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C=CC(=O)Cl.CCN(C(C)C)C(C)C.ClCCl.Nc1ccc2oc(-c3ccc4cc5n(c4c3)C3(CCC3)CNC5=O)nc2c1>>C=CC(=O)Nc1ccc2oc(-c3ccc4cc5n(c4c3)C3(CCC3)CNC5=O)nc2c1",
        "output": "10"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.CCCCc1ccc(N)cc1.CCN(CC)CC.CN(C)c1ccncc1.Cc1ccccc1>>CCCCc1ccc(NC(C)=O)cc1",
        "output": "6"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.C[C@@H](O)[C@H](N)CO.Cn1nc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)c2ccc(F)cc21.F[P-](F)(F)(F)(F)F>>C[C@@H](O)[C@@H](CO)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(F)ccc34)nc12",
        "output": "737"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc(OC)cc(OC)c1.Cl.Cl[Sn](Cl)(Cl)Cl.O=C(Cl)CCCCCl.c1ccccc1>>COc1cc(OC)c(C(=O)CCCCCl)c(OC)c1",
        "output": "31"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N(CCCl)C(C)C.CN(C)CCCOc1ccc(-c2cnc(Nc3ccccc3)s2)cc1.CO.Cl.ClCCl.Oc1ccc(Nc2ncc(-c3ccsc3)s2)cc1>>CC(C)N(CCOc1ccc(Nc2ncc(-c3ccsc3)s2)cc1)C(C)C",
        "output": "74"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CN(C)CCN1C(=O)c2cccc3cc4cccc(N)c4c(c23)C1=O.FC(F)(F)Oc1ccccc1N=C=S>>CN(C)CCN1C(=O)c2cccc3cc4cccc(NC(=S)Nc5ccccc5OC(F)(F)F)c4c(c23)C1=O",
        "output": "474"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN=C=NCCCN(C)C.NCC(=O)NC1CN(C2CCC(c3ccccc3)CC2)C1.O=C(O)C(F)(F)F.O=C(O)c1cc(O)cc(C(F)(F)F)c1>>O=C(CNC(=O)c1cc(O)cc(C(F)(F)F)c1)NC1CN(C2CCC(c3ccccc3)CC2)C1",
        "output": "718"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCI.CN(C)C=O.COC(=O)c1c[nH]c2ccccc12.O.[H-].[Na+]>>CCn1cc(C(=O)OC)c2ccccc21",
        "output": "302"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cn(CCC#N)c2nc(N3CC(NC(=O)OC(C)(C)C)C3)c(F)cc2c1=O.CO.[Li+].[OH-]>>CC(C)(C)OC(=O)NC1CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3CCC#N)C1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCn1nnn(-c2cc(O)c(Cl)cc2Cl)c1=O.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CCCn1nnn(-c2cc(OS(C)(=O)=O)c(Cl)cc2Cl)c1=O",
        "output": "149"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1cc2sc3c(c2[nH]1)CCN(C(=O)OCC)CC3.[K+].[OH-]>>CCOC(=O)N1CCc2sc3cc(C(=O)O)[nH]c3c2CC1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)CBr.CN(C)C=O.COC(=O)C(C)(O)c1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)C(C)(O)c1ccc(OCC(=O)OC(C)(C)C)cc1",
        "output": "393"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N[C@H]1CCC[C@@H]1N(Cc1ccccc1)Cc1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CN[C@H]1CCC[C@@H]1N(Cc1ccccc1)Cc1ccccc1",
        "output": "881"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)c1nc2ccccc2[nH]1.Cn1c(CN2CCC(C(C)(C)O)CC2)nc2c(N3CCOCC3)nc(Cl)nc21>>CC(C)c1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(C(C)(C)O)CC3)n(C)c2n1",
        "output": "916"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#Cc1cnc2ccc(OC(SC)C(=O)O)cc2c1.CC#N.CC(N)(C#N)CO.CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F.O.On1nnc2cccnc21.[Cl-].[Na+]>>C#Cc1cnc2ccc(OC(SC)C(=O)NC(C)(C#N)CO)cc2c1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)CCc1nc2c(c(=O)[nH]1)CCCN2.ClCCl.O=C(O)C(F)(F)F>>O=C(O)CCc1nc2c(c(=O)[nH]1)CCCN2",
        "output": "278"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CNc1ncccc1C#N.CO.Cl>>CNc1ncccc1CN",
        "output": "560"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)NCCOc1cc([N+](=O)[O-])ccc1C#N.ClCCl.O=C(O)C(F)(F)F>>N#Cc1ccc([N+](=O)[O-])cc1OCCN",
        "output": "538"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cc2ccc(NS(C)(=O)=O)cc2[nH]1.O.[Li+].[OH-]>>CS(=O)(=O)Nc1ccc2cc(C(=O)O)[nH]c2c1",
        "output": "152"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)O.CC1CCC(N)CC1C.CCN=C=NCCCN(C)C.Cl.ClCCl>>CC1CCC(NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC(=O)OC(C)(C)C)CC1C",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)N1Cc2cc(F)c(Cl)nc2C=Cc2cc(Cl)ccc21.CC1(C)OB(c2ccc(N3CCOCC3)nc2)OC1(C)C.COc1ccc(-c2nc3c(cc2F)CN(C(C)=O)c2ccccc2C=C3)cn1>>CC(=O)N1Cc2cc(F)c(-c3ccc(N4CCOCC4)nc3)nc2C=Cc2cc(Cl)ccc21",
        "output": "968"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCCl.Nc1cc(-c2c[nH]c3ccccc23)n[nH]1.O=C(O)CCCN1CCCCC1.O=C[O-]>>O=C(CCCN1CCCCC1)Nc1cc(-c2c[nH]c3ccccc23)n[nH]1",
        "output": "795"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(Oc2ccc(Nc3ncnc4[nH]nc(OCCOS(C)(=O)=O)c34)cc2F)cn1.OC[C@H]1CCCN1.[I-].[K+]>>Cc1ccc(Oc2ccc(Nc3ncnc4[nH]nc(OCCN5CCC[C@@H]5CO)c34)cc2F)cn1",
        "output": "496"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cl.Cl[Sn]Cl.Nc1ccc(-c2cccnc2)cc1.O.O.O.O=N[O-].[K+].[Na+].[OH-]>>NNc1ccc(-c2cccnc2)cc1",
        "output": "109"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CO.Cc1cc(O)n[nH]1>>Cc1cc(O)nn1C(=O)OC(C)(C)C",
        "output": "841"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(Cn2nc(N3CCN(C)CC3)c3c(Oc4ccc(NC(=O)c5ccnn(-c6ccc(F)cc6)c5=O)cc4F)ccnc32)cc1.O=C(O)C(F)(F)F>>CN1CCN(c2n[nH]c3nccc(Oc4ccc(NC(=O)c5ccnn(-c6ccc(F)cc6)c5=O)cc4F)c23)CC1",
        "output": "978"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)Cl.Nc1cccc(CO)c1F.O.O=C([O-])[O-].[Na+].[Na+]>>CCOC(=O)Nc1cccc(CO)c1F",
        "output": "102"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.O=S(=O)(O)O.O=S(=O)([O-])[O-].[Ag+2].[K+].[OH-].c1ccc2c(c1)CCCCN2>>Brc1ccc2c(c1)NCCCC2",
        "output": "98"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC1(O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CNC1.CN(C)C=O.CO.Cl.N#Cc1ccc(C=O)cc1.[BH3-]C#N.[Na+]>>CC1(O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CN(Cc2ccc(C#N)cc2)C1",
        "output": "567"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCP(=O)(O)O.CCN(CC)CC.CN(C)c1cc(C(=O)O)ccn1.Cl.ClCCl.N#Cc1ccccc1C1CCCNC1>>CN(C)c1cc(C(=O)N2CCCC(c3ccccc3C#N)C2)ccn1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC[C@H](C)Nc1cc(C(=O)OC)cc(S(=O)(=O)N(C)C)n1.[Li+].[OH-]>>CC[C@H](C)Nc1cc(C(=O)O)cc(S(=O)(=O)N(C)C)n1",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CO.COC(=O)C(C)(C)CNC(=O)c1ncc2cc(NCc3ccc(OC)cc3)ccc2c1O.Cl.O.[Na+].[OH-]>>COc1ccc(CNc2ccc3c(O)c(C(=O)NCC(C)(C)C(=O)O)ncc3c2)cc1",
        "output": "361"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cc2c(Nc3ccc(C)cc3F)ncnc2cc1OCc1ccccc1.Cl.O=C(O)C(F)(F)F>>COc1cc2c(Nc3ccc(C)cc3F)ncnc2cc1O",
        "output": "23"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(=O)O.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O=C([O-])C(F)(F)F.[NH3+]CCNC(=O)c1cnn2cc(Cc3ccc(Br)cc3)cnc12>>CCC(=O)NCCNC(=O)c1cnn2cc(Cc3ccc(Br)cc3)cnc12",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(Cl)c2c1.NCCN>>Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(NCCN)c2c1",
        "output": "78"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(CC2NCCc3cc(OC)c(OC(C)C)cc32)cc1OC.NCc1ccccc1.O=C(Br)CBr>>COc1ccc(CC2c3cc(OC(C)C)c(OC)cc3CCN2CC(=O)NCc2ccccc2)cc1OC",
        "output": "946"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCc1cccc2nn(-c3ccc(C#N)cc3)cc12.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.[F-]>>N#Cc1ccc(-n2cc3c(CO)cccc3n2)cc1",
        "output": "708"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(C(=O)c2ccccc2F)c(Cl)c1Cl.Cl.[Al+3].[Cl-].[Cl-].[Cl-].c1ccccc1>>O=C(c1ccccc1F)c1ccc(O)c(Cl)c1Cl",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.N#CCBr.NC(=O)c1cnc(Nc2ccc(C3CCNCC3)cc2)nc1NC1CC1>>N#CCN1CCC(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1",
        "output": "880"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CS(C)=O.N#C[C@@H]1C[C@H](F)CN1C(=O)CCl.NC12CC3CC1CC(c1ccc(N4CCCS4(=O)=O)cc1)(C3)C2.O=C([O-])[O-].[K+].[K+]>>N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CC3CC1CC(c1ccc(N4CCCS4(=O)=O)cc1)(C3)C2",
        "output": "330"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN1CCC(=O)CC1.CO.ClCCCl.NN1C(=O)Cc2ccccc21.Nc1ccc2c(c1)CC(=O)N2.[Na+]>>CCN1CCC(Nc2ccc3c(c2)CC(=O)N3)CC1",
        "output": "469"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=Cc1ccc(F)cc1.OCc1ccc(Cl)cc1Br>>OCc1ccc(Cl)cc1/C=C/c1ccc(F)cc1",
        "output": "539"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)N.N#Cc1cc(C(=O)O)ccc1Cl.O=C(n1ccnc1)n1ccnc1>>CC(C)NC(=O)c1ccc(Cl)c(C#N)c1",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.N[C@@H]1CCCC[C@H]1N>>Cc1ccc(S(=O)(=O)N[C@@H]2CCCC[C@H]2N)cc1",
        "output": "43"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cc1c(NCC2CC2)nc(C2CC2)nc1OCC(=O)O.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F>>COC(=O)COc1nc(C2CC2)nc(NCC2CC2)c1C",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)OC(COS(C)(=O)=O)Cc1ccc(Cl)cc1.CO.O.[N-]=[N+]=[N-].[Na+]>>CC(C)OC(CN=[N+]=[N-])Cc1ccc(Cl)cc1",
        "output": "322"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC[C@@H](NC(=O)c1ccn2c1COCC2)c1ccccc1.ClCCl.O.O=C1CCC(=O)N1Br.[Na+].[OH-]>>CC[C@@H](NC(=O)c1cc(Br)n2c1COCC2)c1ccccc1",
        "output": "779"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1cnccc1C1CCO1.CC1(C)OB(c2ccc(C#N)c(Cl)c2)OC1(C)C.CCOC(C)=O.CN(C)C=O.ClCCl.Cl[Pd]Cl.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>N#Cc1ccc(-c2cnccc2C2CCO2)cc1Cl",
        "output": "938"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.C[Si](C)(C)C#Cc1c[nH]nc1-c1cccc([N+](=O)[O-])c1.[F-].[K+]>>C#Cc1c[nH]nc1-c1cccc([N+](=O)[O-])c1",
        "output": "337"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(S(=O)Cc2ccc(F)cc2)CC1.O=CO>>O=S(Cc1ccc(F)cc1)C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.[H][H].[OH-].[OH-].[Pd+2].c1ccc(COCCOc2ccc(C3CCCCC3)cc2)cc1>>OCCOc1ccc(C2CCCCC2)cc1",
        "output": "178"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1ccccc1[O-].Cc1ccc(S(=O)(=O)OCC2CC(=O)N(C)C2)cc1.[K+]>>CCc1ccccc1OCC1CC(=O)N(C)C1",
        "output": "438"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CS(C)=O.Nc1nc(Cl)ccc1[N+](=O)[O-].c1ccc(C2CNCCO2)nc1>>Nc1nc(N2CCOC(c3ccccn3)C2)ccc1[N+](=O)[O-]",
        "output": "220"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COc1c(NS(=O)(=O)C(F)(F)F)cc(C(C)(C)C)cc1[N+](=O)[O-].O.[Cl-].[Fe].[NH4+]>>COc1c(N)cc(C(C)(C)C)cc1NS(=O)(=O)C(F)(F)F",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.Cl.NCCCN1c2ccccc2CCc2ccc(Cl)cc21.O=S(=O)(Cl)c1ccc(OC(F)(F)F)cc1>>O=S(=O)(NCCCN1c2ccccc2CCc2ccc(Cl)cc21)c1ccc(OC(F)(F)F)cc1",
        "output": "43"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.Clc1nc2c(c(-c3ccccc3)n1)CCC2.Nc1ccc(C(=O)O)cc1>>O=C(O)c1ccccc1",
        "output": "324"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.N#Cc1cc([N+](=O)[O-])ccc1N.O.[Na+].[OH-]>>N#Cc1cc(N)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.CC(C)(C)O.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CCCCCCC.Cc1nc2ccc(Br)cc2c(-c2ccc(C(F)(F)F)cc2)c1S(C)(=O)=O.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1nc2ccc(N3CCOCC3)cc2c(-c2ccc(C(F)(F)F)cc2)c1S(C)(=O)=O",
        "output": "294"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CC(N2CCC3(CCNCC3)CC2)C1.CS(C)=O.Clc1ccc(Cl)nn1.O.O=C([O-])[O-].[K+].[K+]>>Clc1ccc(N2CCC3(CC2)CCN(C2CCC2)CC3)nn1",
        "output": "406"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1ccc2c(c1)CCNC2.ClCCl.Oc1ccc2c(c1)CCNC2>>CC(C)(C)OC(=O)N1CCc2cc(O)ccc2C1",
        "output": "867"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br.Cc1nccn1-c1ccc(N)cc1.O.O=N[O-].[Na+]>>Cc1nccn1-c1ccc(Br)cc1",
        "output": "373"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)CC(CCCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCCc1cccnc1.CO.[Na+].[OH-]>>O=C(O)CC(CCCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCCc1cccnc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CS(=O)(=O)c1ccc(B(O)O)cc1.Cc1cccc(C#Cc2ccnc(Cl)c2)n1.Cc1ccccc1.O.O=C([O-])[O-].[Na+].[Na+]>>Cc1cccc(C#Cc2ccnc(-c3ccc(S(C)(=O)=O)cc3)c2)n1",
        "output": "865"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCc1nc2c(C)ccc(OCCCCN3CNC4CC=CC=C43)c2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCCCc1nc2c(C)ccc(OCCCCN3CNC4CC=CC=C43)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)c1cccc(Cl)c1.CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(CCN)c1cccc(Cl)c1.CC1(c2cccc(Cl)c2)C=CC=C(C=CC#N)C1.COc1cccc(C(C)=O)c1.[2H][2H].[BH3-]C#N.[Na+].[OH-].[OH-].[Pd+2].[Ti+4]>>COc1cccc(C(C)NCCC(C)c2cccc(Cl)c2)c1",
        "output": "693"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCc1ccc(CCOc2ccc([N+](=O)[O-])cc2)nc1.Cc1ccccc1.[H][H].[Pd]>>CCc1ccc(CCOc2ccc(N)cc2)nc1",
        "output": "202"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccccc1.Cc1oc(-c2ccccc2)nc1COc1ccc(CO)cc1.O=S(Cl)Cl>>Cc1oc(-c2ccccc2)nc1COc1ccc(CCl)cc1",
        "output": "81"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.N#CCCSc1ccc(N)c([N+](=O)[O-])c1.O.[Fe]>>N#CCCSc1ccc(N)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc(C(F)COCc4ccccc4)c(-c4cc5c(F)cccc5[nH]4)n3)cc12.[OH-].[OH-].[Pd+2]>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc(C(F)CO)c(-c4cc5c(F)cccc5[nH]4)n3)cc12",
        "output": "178"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.ClCCCCBr.OCc1cc2ccccn2n1.[H-].[Na+]>>ClCCCCOCc1cc2ccccn2n1",
        "output": "95"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1cccc(OCc2ccccc2)c1.CC(C)(C)C(=O)CC(=O)C(C)(C)C.CN1CCCC1=O.COC(=O)CCc1ccc(O)cc1C.Cl[Cu].O>>COC(=O)CCc1ccc(Oc2cccc(OCc3ccccc3)c2)cc1C",
        "output": "238"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1CCN(CCCO)CC1.N#Cc1ccc(Cl)nc1.[H-].[Na+]>>CN1CCN(CCCOc2ccc(C#N)cn2)CC1",
        "output": "433"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C1COCCN1.CC(C)C1=CC(C(C)C)=C(c2ccccc2)C(C(C)C)(P(C2CCCCC2)C2CCCCC2)C1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.COc1ccc(-c2cnc(Cl)cc2N)cn1.C[Si](C)(C)[N-][Si](C)(C)C.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Li+].[Pd].[Pd]>>COc1ccc(-c2cnc(N3CCOCC3)cc2N)cn1",
        "output": "220"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1=COC=CO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1c(Br)cncc1C1CC1.ClCCl.[K+]>>Cc1c(B2OC(C)(C)C(C)(C)O2)cncc1C1CC1",
        "output": "943"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(O)c1cc(C(=O)O)n[nH]1.CN(C)C=O.C[C@H](N)Cn1ccc(-c2cc(F)c(C#N)c(Cl)c2)n1.O.On1nnc2ccccc21>>C[C@@H](Cn1ccc(-c2cc(F)c(C#N)c(Cl)c2)n1)NC(=O)c1cc(C(C)(C)O)[nH]n1",
        "output": "816"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN(C)C(=O)Cl.CS(C)=O.O=C1c2cc(CN3CCC(F)(F)CC3)c3cccnc3c2CN1c1cccc(O)c1.[H-].[Na+]>>CN(C)C(=O)Oc1cccc(N2Cc3c(cc(CN4CCC(F)(F)CC4)c4cccnc34)C2=O)c1",
        "output": "425"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC(=O)NC(C)(C)Cn1c(COCC)nc2cnc3ccccc3c21.ClCCl.O=C(OO)c1cccc(Cl)c1>>CCOCC(=O)NC(C)(C)Cn1c(COCC)nc2c[n+]([O-])c3ccccc3c21",
        "output": "820"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(Cl)c1ccc(-n2cccn2)cc1.O=C1C(=O)c2ccccc2C2=C1SCC1(CCNCC1)O2>>O=C1C(=O)c2ccccc2C2=C1SCC1(CCN(C(=O)c3ccc(-n4cccn4)cc3)CC1)O2",
        "output": "201"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrC(Br)(Br)Br.ClCCl.O=Cc1ccc2c(c1)[nH]c(=O)n2CCCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=Cc1ccc2c(c1)[nH]c(=O)n2CCCBr",
        "output": "378"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOCC.CN(CCNC1CCCc2cc(S(=O)(=O)c3ccccc3)ccc21)C(=O)OC(C)(C)C.Cl>>CNCCNC1CCCc2cc(S(=O)(=O)c3ccccc3)ccc21",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN.CCN(CC)CC.Cl.O=C(O)c1ccc(Br)cc1F>>CCNC(=O)c1ccc(Br)cc1F",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CNS(=O)(=O)CCc1ccc(N)cc1.ClCCl.O=C1CCC(=O)N1Br>>CNS(=O)(=O)CCc1ccc(N)c(Br)c1",
        "output": "4"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Cl.O.O=C1CCCc2cc(O)ccc21.O=Cc1ccc(Br)cc1>>O=C1C(=Cc2ccc(Br)cc2)CCc2cc(O)ccc21",
        "output": "85"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)c1nc(N2CCNCC2)cc(C2(C)CC2)n1.CCN(CC)CC.CN(C)C=O.ClCCCBr.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)c1nc(N2CCN(CCCCl)CC2)cc(C2(C)CC2)n1",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCN.ClCCl.O=C(Cl)c1ccc2c(c1)N=C(Cl)c1ccc(F)cc1S2>>CCCCNC(=O)c1ccc2c(c1)N=C(Cl)c1ccc(F)cc1S2",
        "output": "271"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCOc1ccc2c(=O)c3ccccc3oc2c1C(C)=O.CCO.O.O=Cc1ccccc1.[K+].[OH-]>>C=CCOc1ccc2c(=O)c3ccccc3oc2c1C(=O)C=Cc1ccccc1",
        "output": "295"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CCCCCC.CCOC(C)=O.CN(C)CC[C@H](O)c1cccs1.CS(C)=O.Fc1cccc2ccccc12.O.O=C([O-])c1ccccc1.[H-].[K+].[Na+]>>CN(C)CC[C@H](Oc1cccc2ccccc12)c1cccs1",
        "output": "485"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CCOC(=O)N1CCC(=O)C(CC)C1.CO.[BH3-]C#N.[NH4+].[Na+]>>CCOC(=O)N1CCC(N)C(CC)C1",
        "output": "63"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1cc(Cl)c(Cl)c(OC)c1.Cl.[Na+].[OH-]>>COc1cc(C(=O)O)cc(Cl)c1Cl",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCNCC1.CC(C)=O.CCN1CCN(c2ccc([N+](=O)[O-])c(N)c2)CC1.ClCCl.O.[Na+]>>CC(C)N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "187"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)c1ncco1.ClCCl.NCCN.O=C(O)C(F)(F)F>>CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)c1ncco1",
        "output": "981"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)[S-].CN(C)C=O.COc1cc2nccc(Nc3n[nH]c(C)c3C)c2cc1S(=O)(=O)C(C)(C)C.[Na+]>>Cc1[nH]nc(Nc2ccnc3cc(O)c(S(=O)(=O)C(C)(C)C)cc23)c1C",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC(C)(O)c1cc(Br)cc(C(C)(C)O)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CS(C)=O.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(O)c1cc(B2OC(C)(C)C(C)(C)O2)cc(C(C)(C)O)c1",
        "output": "942"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "N[C@H]1CCCc2ccccc21.O=Cc1cccc([N+](=O)[O-])c1>>O=[N+]([O-])c1cccc(CN[C@H]2CCCc3ccccc32)c1",
        "output": "683"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1c(C(=O)O)c2cnc(Br)cc2n1C(C)C.F[P-](F)(F)(F)(F)F.NC1CCOCC1.O=C([O-])O.[Na+]>>Cc1c(C(=O)NC2CCOCC2)c2cnc(Br)cc2n1C(C)C",
        "output": "674"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)c1cccc([N+](=O)[O-])c1C#N.CO.Cl.[Fe]>>CN(C)c1cccc(N)c1C#N",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C[O-].Cc1ccccc1.FC(F)(F)c1ccc(Cc2c(Cl)nc3ccc(I)cc3c2Cl)cc1.O=C([O-])O.[Na+].[Na+]>>COc1nc2ccc(I)cc2c(Cl)c1Cc1ccc(C(F)(F)F)cc1",
        "output": "433"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1cc(C(=O)OCC)cc(-c2ncc[nH]2)c1.CI.[H-].[Na+]>>CCOC(=O)c1cc(C(=O)OCC)cc(-c2nccn2C)c1",
        "output": "404"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1cccc(CNc2cncc(-c3cccc(O)c3)c2)c1.O.[Li+].[OH-]>>O=C(O)c1cccc(CNc2cncc(-c3cccc(O)c3)c2)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)C1CCC(=O)C(C(C)(C)C)C1.CC(C)(C)c1ccc(O)c(C(C)(C)C)c1.[Ni]>>CC(C)(C)C1CCC(O)C(C(C)(C)C)C1",
        "output": "91"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCC(C)(c1ccc(O)c(C)c1)c1ccc(O)c(C)c1.O.[NH4+].[OH-]>>Cc1cc(C(C)(CCC(N)=O)c2ccc(O)c(C)c2)ccc1O",
        "output": "163"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCSCCCN(CC)CC(O)CNc1ccc(C#N)cc1.CCO.Cc1ccc(S(=O)(=O)O)cc1.O=C(OO)c1cccc(Cl)c1.[Ca+2].[OH-].[OH-]>>CCCS(=O)CCCN(CC)CC(O)CNc1ccc(C#N)cc1",
        "output": "13"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CCc1c(C)c2c(c(C)c1O)C(C)(C)CC(=O)O2.CCN(C(C)C)C(C)C.COCCl.ClCCl>>C=CCc1c(C)c2c(c(C)c1OCOC)C(C)(C)CC(=O)O2",
        "output": "375"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)CC(=O)O.CN1CCCC1=O.CS(C)=O.F[P-](F)(F)(F)(F)F.N[C@@H]1CC[C@@H](Nc2cc(-c3cccc(NCc4cccc(F)c4)n3)c(Cl)cn2)CC1>>CN(C)CC(=O)N[C@@H]1CC[C@@H](Nc2cc(-c3cccc(NCc4cccc(F)c4)n3)c(Cl)cn2)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)/C=C/[C@@H]1CC[C@@H](c2ccc(C(=O)Nc3nc(Cc4ccccc4)no3)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)/C=C/[C@@H]1CC[C@@H](c2ccc(C(=O)Nc3nc(Cc4ccccc4)no3)cc2)CC1",
        "output": "158"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCBr.CCC(C)=O.COc1ccc(CNc2cn[nH]c(=O)c2Cl)cc1OCCN1CCN(Cc2ccc(F)cc2)CC1.O=C([O-])[O-].[K+].[K+]>>CCn1ncc(NCc2ccc(OC)c(OCCN3CCN(Cc4ccc(F)cc4)CC3)c2)c(Cl)c1=O",
        "output": "577"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC1(N)CN(C(=O)OC(C)(C)C)C1.CCN(CC)CC.COc1ccc(Br)cc1S(=O)(=O)Cl>>COc1ccc(Br)cc1S(=O)(=O)NC1(C)CN(C(=O)OC(C)(C)C)C1",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(COc2ccc(Br)cc2)CC1.O.O=C([O-])[O-].OB(O)c1ccc(O)cc1.[Cs+].[Cs+]>>CC(C)(C)OC(=O)N1CCC(COc2ccc(-c3ccc(O)cc3)cc2)CC1",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Nc1ccc(I)cc1F.O=C1COCCN1>>Nc1ccc(N2CCOCC2=O)cc1F",
        "output": "921"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCOc1ccc(N2CCN(C(=O)CC3OCCc4cc(Br)ccc43)CC2)cc1.COc1ccccc1N1CCN(CCC2OCCc3ccccc32)CC1.Cl.Cl.O.O=C(O)CC1OCCc2cc(Br)ccc21>>CCCCOc1ccc(N2CCN(CCC3OCCc4cc(Br)ccc43)CC2)cc1",
        "output": "112"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)CCCCBr.FC(F)(F)c1ccc(CBr)o1.O=C1Nc2cccc(Br)c2C12COc1cc3c(cc12)OCO3.O=C1Nc2ccccc2C12COc1cc3c(cc12)OCO3>>CCOC(=O)CCCCN1C(=O)C2(COc3cc4c(cc32)OCO4)c2ccccc21",
        "output": "367"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.COC(=O)c1ccccc1-c1ccc(CNc2nc(NCCC(C)C)nc3ccccc23)cc1.Cl.[Na+].[OH-]>>CC(C)CCNc1nc(NCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.OCc1nc2ccc3nsccc3c2n1>>Cc1ccc(S(=O)(=O)OCc2nc3ccc4nsccc4c3n2)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(CNS(=O)(=O)c2c(Cl)ccc([N+](=O)[O-])c2O)CC1.[H][H].[Pd]>>CC(C)(C)OC(=O)N1CCC(CNS(=O)(=O)c2c(Cl)ccc(N)c2O)CC1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)C(C)(C)c1ccc(C)cc1.CCO.O.O=Cc1cccc(Oc2ccccc2)c1.[K+].[OH-]>>Cc1ccc(C(C)(C)C(=O)C=Cc2cccc(Oc3ccccc3)c2)cc1",
        "output": "295"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CSc1nc(O)c(C#N)c(-c2ccc(Cl)c(Cl)c2)n1.O=P(Cl)(Cl)Cl>>CSc1nc(Cl)c(C#N)c(-c2ccc(Cl)c(Cl)c2)n1",
        "output": "168"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCC1CCC(C2CCC(CCC(=O)OCC)CC2)CC1.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[Li+].[NH4+]>>CCCC1CCC(C2CCC(CCCO)CC2)CC1",
        "output": "225"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCc1cc(NC(=O)Oc2ccccc2)c(OC)nc1C.Cc1cccc(C)c1N1CCNCC1>>CCc1cc(NC(=O)N2CCN(c3c(C)cccc3C)CC2)c(OC)nc1C",
        "output": "525"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)Nc1cnccc1C(=O)O.CO.Cl>>Nc1cnccc1C(=O)O",
        "output": "877"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1CCCCC1N.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@@H]1CC[C@H](C(=O)O)CN1c1cc(-c2ccc(C#N)c(F)c2)nc(N)n1.F[P-](F)(F)(F)(F)F.O>>CC1CCCCC1NC(=O)[C@H]1CC[C@@H](C)N(c2cc(-c3ccc(C#N)c(F)c3)nc(N)n2)C1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CN(C)C=O.COc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1N.O.O=CCCCCl.O=S(=O)(O)O.[BH4-].[Na+]>>COc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NCCCCCl",
        "output": "336"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.Fc1cccc(CBr)c1.O=C([O-])[O-].Oc1ccc(-c2cc(Cn3ccnc3)on2)cc1.[K+].[K+]>>Fc1cccc(COc2ccc(-c3cc(Cn4ccnc4)on3)cc2)c1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(CNC(=O)c2cc(Cl)cnc2Oc2ccc(F)cc2)cc1.Cl.[Na+].[OH-]>>O=C(O)c1ccc(CNC(=O)c2cc(Cl)cnc2Oc2ccc(F)cc2)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#Cc1ncc(-c2ccc(Cl)cc2)cc1Cl.OCCOc1ccc(I)cc1>>OCCOc1ccc(C#Cc2ncc(-c3ccc(Cl)cc3)cc2Cl)cc1",
        "output": "664"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCOC(C)=O.COCCl.O.O=C([O-])[O-].Oc1cc(Br)ccc1Cl.[K+].[K+]>>COCOc1cc(Br)ccc1Cl",
        "output": "375"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc2[nH]c(=O)c3sccc3c2c1Br.C[C@@H](CNC(=O)OC(C)(C)C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1>>COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc([C@@H](C)CNC(=O)OC(C)(C)C)cc1",
        "output": "972"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCOCCOCCOCCOCCO1.CC#N.CCOC(=O)c1c(-c2ccc(O)cc2)c(C#N)cn1C.ClCCl.O.O=[N+]([O-])c1ccccc1F>>CCOC(=O)c1c(-c2ccc(Oc3ccccc3[N+](=O)[O-])cc2)c(C#N)cn1C",
        "output": "564"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NC1CCCNC1.CCN(C(C)C)C(C)C.CCO.O=[N+]([O-])c1ccccc1F>>CC(C)(C)OC(=O)NC1CCCN(c2ccccc2[N+](=O)[O-])C1",
        "output": "26"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCOC(C)=O.CN(C)c1ccc(P(C(C)(C)C)C(C)(C)C)cc1.CN(C)c1ccc(P(C(C)(C)C)C(C)(C)C)cc1.Cl[Pd]Cl.O.O=P([O-])([O-])[O-].O=[N+]([O-])c1cccc2c(Cl)nccc12.OB(O)c1ccccc1.[K+].[K+].[K+]>>O=[N+]([O-])c1cccc2c(-c3ccccc3)nccc12",
        "output": "865"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CN.Cc1cccc(Nc2cc(Nc3cccc(OCC4CO4)c3)ncn2)c1.O>>CNCC(O)COc1cccc(Nc2cc(Nc3cccc(C)c3)ncn2)c1",
        "output": "16"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CCCCCCC(=O)O.CCCCCC.COc1cc(CCCO)ccc1O>>COc1cc(CCCOC(=O)CCCCCCC(C)C)ccc1O",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N1CCNCC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.Cc1cc(C=O)cc(NC(=O)OC(C)(C)C)c1.O=C([O-])O.[Na+].[Na+]>>CC(=O)N1CCN(Cc2cc(C)cc(NC(=O)OC(C)(C)C)c2)CC1",
        "output": "567"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc2c(c1)OC[C@@H](c1ccc(F)cc1)[C@@H]2c1ccc(OCCN2CCCCC2)cc1.Cl.c1ccncc1>>Oc1ccc2c(c1)OC[C@@H](c1ccc(F)cc1)[C@@H]2c1ccc(OCCN2CCCCC2)cc1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2ccoc2)cc1[N+](=O)[O-].[Ni]>>CC(C)(C)OC(=O)Nc1ccc(-c2ccoc2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(CC)CC.COc1ccc(N2CCNCC2)cc1.CS(=O)(=O)OCCCNc1ccnc2cc(Cl)ccc12.O=C([O-])O.[Na+]>>COc1ccc(N2CCN(CCCNc3ccnc4cc(Cl)ccc34)CC2)cc1",
        "output": "496"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.CS(=O)(=O)c1nccc(Oc2ccc(NC(=O)c3cc(F)cc(N4CCOCC4)c3)c3ccccc23)n1.CS(C)=O.ClCCl>>COc1nccc(Oc2ccc(NC(=O)c3cc(F)cc(N4CCOCC4)c3)c3ccccc23)n1",
        "output": "667"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2ccc(F)cc2Cl)CN1.O=C(O)Cn1nccn1>>O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2ccc(F)cc2Cl)CN1C(=O)Cn1nccn1",
        "output": "297"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.CN1CCN(c2ccc(Br)cc2C#N)CC1.O.[K+]>>CN1CCN(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2C#N)CC1",
        "output": "942"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)(C)OC(=O)CC[C@@H](CO)NC(=O)OCc1ccccc1.CI.O=[Ag]>>COC[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1",
        "output": "140"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.C1COCCO1.COc1ccc(F)cc1C(=O)c1cnc(NC2CCN(S(=O)(=O)CCCCl)CC2)nc1N.[I-].[K+]>>COc1ccc(F)cc1C(=O)c1cnc(NC2CCN(S(=O)(=O)CCCN3CCCC3)CC2)nc1N",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1nnc2n1CCNC2C.O=C(O)c1cc2ncc(Cl)cn2n1>>Cc1nnc2n1CCN(C(=O)c1cc3ncc(Cl)cn3n1)C2C",
        "output": "663"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC[C@H](NC(=O)OC(C)(C)C)C(=O)O.CCN(CC)CC.Cc1ccc(C(=O)NC[C@@H](N)C(C)C)cc1.Cl.ClCCl.O=C(n1ccnc1)n1ccnc1>>CCC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](CNC(=O)c1ccc(C)cc1)C(C)C",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)N=C=O.CCn1cc(-c2ccnc3[nH]ccc23)c(-c2ccc(N)cc2)n1.ClCCl.O.c1ccncc1>>CCn1cc(-c2ccnc3[nH]ccc23)c(-c2ccc(NC(=O)NC(C)C)cc2)n1",
        "output": "176"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)/N=N/C(=O)OCC.CCOC(C)=O.COCCOCCO.Cc1ccccc1.Cc1ccccc1C(=O)c1ccc(Nc2ccccc2NC(=O)CCC(=O)O)cc1Cl.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COCCOCCOC(=O)CCC(=O)Nc1ccccc1Nc1ccc(C(=O)c2ccccc2C)c(Cl)c1",
        "output": "47"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc(CN(C)CCN(C)Cc2ccc(Oc3ccc(-c4ncco4)cc3)cc2)cc1.[Na+].[OH-]>>CN(CCN(C)Cc1ccc(C(=O)O)cc1)Cc1ccc(Oc2ccc(-c3ncco3)cc2)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCI.CCO.CCOC(=O)C(CC)c1ccc(C(=O)c2ccc(Cl)cc2)n1C.CCOC(=O)Cc1ccc(C(=O)c2ccc(Cl)cc2)n1C.CCOCC.Cl.N.[Cl-].[NH2-].[NH4+].[Na+].[Na+].[OH-]>>CCC(C(=O)O)c1ccc(C(=O)c2ccc(Cl)cc2)n1C",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cc1ccccc1.O=C(O)c1cc(Cl)cnc1Cl.O=C([O-])O.O=S(=O)(O)O.[Na+]>>CCOC(=O)c1cc(Cl)cnc1Cl",
        "output": "521"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C[C@@H](CO)CF.Cc1cccc(C)n1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>C[C@H](CF)COS(=O)(=O)C(F)(F)F",
        "output": "582"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)C(C)(C)COc1c(-c2ccc3c(c2)COC3=O)ccc(OC)c1OC.O.[Li+].[OH-]>>COc1ccc(-c2ccc3c(c2)COC3=O)c(OCC(C)(C)C(=O)O)c1OC",
        "output": "361"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1cc(Br)ccc1O.[K+].[K+]>>O=[N+]([O-])c1cc(Br)ccc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C(O)c1cnc(Cl)c(-c2ccc(Cl)cc2)c1.OCC(F)(F)F>>O=C(O)c1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1",
        "output": "433"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.Cc1cc([N+](=O)[O-])cnc1Cl.O=C(OCc1ccccc1)N1CCC([C@H]2C[C@H]2CCO)CC1.[H-].[Na+]>>Cc1cc([N+](=O)[O-])cnc1OCC[C@@H]1C[C@@H]1C1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "433"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCc1ccccc1.CCN(CC)C(=O)c1ccc(C(CCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)c2cccc(OC)c2)cc1.CN(C)C=O.O.[H-].[Na+]>>CCN(CC)C(=O)c1ccc(C(CCN2CCC(n3c(=O)n(Cc4ccccc4)c4ccccc43)CC2)c2cccc(OC)c2)cc1",
        "output": "658"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@H](N)C(C)(C)C.Cn1nc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)c2ccc(F)cc21.F[P-](F)(F)(F)(F)F.O>>C[C@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)C(C)(C)C",
        "output": "737"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)C=Cc1ccccc1.[Na+].[OH-]>>COc1ccc(C[C@H](NC(=O)C=Cc2ccccc2)C(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)Cc1cccc(OCc2cccc(OCc3nc(-c4ccccc4)oc3C)n2)c1.[Na+].[OH-]>>Cc1oc(-c2ccccc2)nc1COc1cccc(COc2cccc(CC(=O)O)c2)n1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cl.Cl[Sn]Cl.O=C1NC(=O)C(=Cc2cccc(-c3cccc([N+](=O)[O-])c3O)c2)S1>>Nc1cccc(-c2cccc(C=C3SC(=O)NC3=O)c2)c1O",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COCCN.Cl.O=C(O)C1=Cc2c(ncnc2Nc2ccc(Oc3cccc(C(F)(F)F)c3)c(Cl)c2)NCC1.On1nnc2ccccc21>>COCCNC(=O)C1=Cc2c(ncnc2Nc2ccc(Oc3cccc(C(F)(F)F)c3)c(Cl)c2)NCC1",
        "output": "549"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1cc2c(Oc3ccc([N+](=O)[O-])cc3)ccnc2o1.[Fe]>>COC(=O)c1cc2c(Oc3ccc(N)cc3)ccnc2o1",
        "output": "335"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Oc1c(C(C)(C)C)cc2c(c1C(C)(C)C)CC(C)(COc1ccc(NC(=N)N)cc1)O2.CC(C)C[Al+]CC(C)C.Cc1ccccc1.[Cl-].[H-].[NH4+]>>CC1(COc2ccc(NC(=N)N)cc2)Cc2c(cc(C(C)(C)C)c(O)c2C(C)(C)C)O1",
        "output": "22"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.COc1ccc2c(c1)C(C)(C)CNC2>>CC1(C)CNCc2ccc(O)cc21",
        "output": "207"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCC.CCOC(C)=O.CNc1nc(Cl)ccc1[N+](=O)[O-]>>CNc1nc(Cl)ccc1N",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCCOc1ccc(C=O)cc1.NCCc1ccccc1F>>CCCCCCCCOc1ccc(CNCCc2ccccc2F)cc1",
        "output": "468"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COC(=O)c1cc2cc(O)ccc2s1.ClCc1cccnc1.O.[H-].[Na+]>>COC(=O)c1cc2cc(OCc3cccnc3)ccc2s1",
        "output": "678"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CSCC[C@@H](CO)NC(=O)C1(NC(=O)c2ccc(CN3CCOCC3)cc2)CCCCC1.ClCCl.O=C([O-])O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>CSCC[C@@H](C=O)NC(=O)C1(NC(=O)c2ccc(CN3CCOCC3)cc2)CCCCC1",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.COc1ccccc1N1CCN(CCCCl)CC1.Fc1c(F)c(F)c(OC2CCNCC2)c(F)c1F.O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>COc1ccccc1N1CCN(CCCN2CCC(Oc3c(F)c(F)c(F)c(F)c3F)CC2)CC1",
        "output": "138"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCSc1ccc(C(=O)O)c(OCCCNC(=O)OC(C)(C)C)c1.Cc1ccc(N)c(C(=O)Nc2ccc(Cl)cn2)n1>>CCSc1ccc(C(=O)Nc2ccc(C)nc2C(=O)Nc2ccc(Cl)cn2)c(OCCCNC(=O)OC(C)(C)C)c1",
        "output": "759"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1sc2cc(OCCCCBr)ccc2c1-c1ccc(C(F)(F)F)cc1.OC1CCNCC1>>Cc1sc2cc(OCCCCN3CCC(O)CC3)ccc2c1-c1ccc(C(F)(F)F)cc1",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2ccc(O)cc2)C(O)C1.ClCc1ccccc1>>CC(C)(C)OC(=O)N1CCC(c2ccc(OCc3ccccc3)cc2)C(O)C1",
        "output": "49"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.ClCCl.OB(O)c1cccc(F)c1.Oc1ccccc1Br.[Cu+2]>>Fc1cccc(Oc2ccccc2Br)c1",
        "output": "920"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(C(=O)O)c(OC(C)C)cc12.CO.[BH4-].[Na+]>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(CO)c(OC(C)C)cc12",
        "output": "72"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCC12CCC(c3ccc(C(=O)O)cc3)(CC1)CC2.CCCCCc1ccc(O)c(C#N)c1C#N.Cl.O=S(Cl)Cl.c1ccncc1>>CCCCCc1ccc(OC(=O)c2ccc(C34CCC(CCCCC)(CC3)CC4)cc2)c(C#N)c1C#N",
        "output": "355"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C/C=C/[C@@H](c1ccc(-c2ccc(F)cc2)cc1)[C@H](NC(=O)OC(C)(C)C)C(=O)OC.C1CCOC1.CO.[Li+].[OH-]>>C/C=C/[C@@H](c1ccc(-c2ccc(F)cc2)cc1)[C@H](NC(=O)OC(C)(C)C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CSc1ccc(C(=O)CBr)cc1.ClCCl.O.O=C([O-])[O-].O=S(=O)([O-])O.Oc1ccc(F)cc1F.[K+].[K+]>>CSc1ccc(C(=O)COc2ccc(F)cc2F)cc1",
        "output": "221"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(C)=O.Cc1ccc(S(=O)(=O)n2ccc3c4c(cnc32)CCCN4C2CCCCC2)cc1.O.[Na+].[OH-]>>c1cc2c3c(cnc2[nH]1)CCCN3C1CCCCC1",
        "output": "949"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCOC(=O)C1(CNc2c([N+](=O)[O-])cnc3ccccc23)CCCCC1.[Pt]>>CCOC(=O)C1(CNc2c(N)cnc3ccccc23)CCCCC1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrB(Br)Br.CO.COc1cc(OC)c(-c2ccccc2F)cc1-c1ccccc1F.ClCCl.O>>Oc1cc(O)c(-c2ccccc2F)cc1-c1ccccc1F",
        "output": "20"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cccc(NS(=O)(=O)c2ccc(-c3ccc(Cl)cc3)cc2)n1.Cc1cccc(NS(=O)(=O)c2ccc(Br)cc2F)n1.N#Cc1ccc(B(O)O)cc1>>Cc1cccc(NS(=O)(=O)c2ccc(-c3ccc(C#N)cc3)cc2F)n1",
        "output": "837"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "N#Cc1ccc(N(CCO)CC(F)(F)F)cc1C(F)(F)F.NS(=O)(=O)c1ccc(O)cc1>>N#Cc1ccc(N(CCOc2ccc(S(N)(=O)=O)cc2)CC(F)(F)F)cc1C(F)(F)F",
        "output": "478"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(CCN)OCC.C[C@H](NC(=O)OCc1ccccc1)C(=O)O.Cl.Oc1cccc2[nH]nnc12>>CCOC(CCNC(=O)[C@H](C)NC(=O)OCc1ccccc1)OCC",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.Cl.ClC(Cl)Cl.O.O=C(Nc1ccc(C(=O)c2ccccc2)cc1)Oc1ccccc1.O=C1OC2(CCNCC2)c2ccccc21>>O=C(c1ccccc1)c1ccc(NC(=O)N2CCC3(CC2)OC(=O)c2ccccc23)cc1",
        "output": "525"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1cccc(-c2ccc3c(-c4cccc(N)c4)c(OC)ccc3c2)c1>>Nc1cccc(-c2c(O)ccc3cc(-c4cccc(O)c4)ccc23)c1",
        "output": "20"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.Nc1ccc(C(F)(F)F)cc1CO.O=N[O-].O=S(=O)(O)O.[I-].[K+].[Na+]>>OCc1cc(C(F)(F)F)ccc1I",
        "output": "200"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=NS(=O)(=O)c1ccccc1-c1ccc(CBr)cc1.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+].c1ccc(-c2nc(-c3ccccc3)c(-c3ccccc3)[nH]2)cc1>>CN(C)C=NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(-c3ccccc3)nc(-c3ccccc3)c2-c2ccccc2)cc1",
        "output": "658"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CS(=O)(=O)O.O=C(NC(c1ccccc1)C(O)C(=O)O)OCc1ccccc1>>CCOC(=O)C(O)C(NC(=O)OCc1ccccc1)c1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O.OCCOCCOCCCl.[Br-].[I-].[K+].[K+].[N-]=[N+]=[N-].[Na+]>>[N-]=[N+]=NCCOCCOCCO",
        "output": "243"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COc1cc(C=O)ccc1O.Cc1oc(-c2cccc(OS(C)(=O)=O)c2)nc1CCl.O.O=C([O-])[O-].[K+].[K+]>>COc1cc(C=O)ccc1OCc1nc(-c2cccc(OS(C)(=O)=O)c2)oc1C",
        "output": "760"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COC(=O)c1cc(-c2ccc3cc(OC)ccc3c2)ccc1F.ClCCl>>COC(=O)c1cc(-c2ccc3cc(O)ccc3c2)ccc1F",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN.COc1cc2c(c(-c3cc(Cl)ccc3OC)c1)OC(COS(=O)(=O)c1ccc(C)cc1)C2>>CNCC1Cc2cc(OC)cc(-c3cc(Cl)ccc3OC)c2O1",
        "output": "853"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cc(S(C)(=O)=O)ccc1OCCCCN.c1ccc(OCC2CO2)cc1>>COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cc(S(C)(=O)=O)ccc1OCCCCNCC(O)COc1ccccc1",
        "output": "16"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCc1cc(CC)n(C[C@@H]2CC[C@@H](N)CC2)n1.Cc1ncc(Cl)cc1C(=O)Cl.Cl.ClCCl>>CCc1cc(CC)n(C[C@@H]2CC[C@@H](NC(=O)c3cc(Cl)cnc3C)CC2)n1",
        "output": "353"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C(=O)O)n1cc(I)c2cnc(Cl)nc21.CC(C)COC(=O)Cl.CCN(CC)CC.O.[BH4-].[Na+]>>CC(C)(CO)n1cc(I)c2cnc(Cl)nc21",
        "output": "231"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.OCc1ccc(OCCBr)cc1.OCc1ccc(OCCCl)cc1.Oc1ccc(Cl)c2ccccc12>>ClCCOc1ccc(COc2ccc(Cl)c3ccccc23)cc1",
        "output": "347"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CCc1nn(Cc2ccc(C)nc2OC)c2cccc(NC(=O)c3cnc4ccccn34)c12.Cl.O.O=C([O-])O.[Na+]>>CCc1nn(Cc2ccc(C)nc2O)c2cccc(NC(=O)c3cnc4ccccn34)c12",
        "output": "408"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCc1cc(CO)nc(C(F)(F)F)c1.ClCCl>>CCc1cc(C=O)nc(C(F)(F)F)c1",
        "output": "263"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C(N1CCC(C2Cc3ccccc3O2)CC1)C(F)(F)F.O=C1CCC(=O)N1Br>>O=C(N1CCC(C2Cc3cc(Br)ccc3O2)CC1)C(F)(F)F",
        "output": "4"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CN(C)C=O.CNC(=O)c1cc(CSc2nc(Cl)c(C#N)c(-c3ccccc3)c2C#N)ccn1.CNCCO.O>>CNC(=O)c1cc(CSc2nc(N(C)CCO)c(C#N)c(-c3ccccc3)c2C#N)ccn1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COC(=O)Cc1c(Cl)nc(Cc2ccc(N)cc2)nc1N(C)CC(=O)NC1CCCC1.ClCCCl.O.O=CC1CCCCC1.[Na+].[Na+].[OH-]>>COC(=O)Cc1c(Cl)nc(Cc2ccc(NCC3CCCCC3)cc2)nc1N(C)CC(=O)NC1CCCC1",
        "output": "336"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COc1cc(-c2cccc(Cl)c2)c2cc(C(O)(c3cccnc3)c3cccnc3)ccc2n1.Cl>>O=c1cc(-c2cccc(Cl)c2)c2cc(C(O)(c3cccnc3)c3cccnc3)ccc2[nH]1",
        "output": "758"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)CCn1c(=O)n(Cc2ccc(Cl)c3c(C)c(C)n(C)c23)c2ccccc21.O.O.[Li+].[OH-]>>Cc1c(C)n(C)c2c(Cn3c(=O)n(CCC(=O)O)c4ccccc43)ccc(Cl)c12",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)N(Cc1cccnc1)Cc1cc(C(F)(F)F)ccc1-c1cc(C(C)C)ccc1OC.ClCCl.O=C(OO)c1cccc(Cl)c1.O=S([O-])O.[Na+]>>COC(=O)N(Cc1ccc[n+]([O-])c1)Cc1cc(C(F)(F)F)ccc1-c1cc(C(C)C)ccc1OC",
        "output": "262"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Fc1ccccc1Br.O=C1N(c2ccc(OC(F)(F)F)cc2)CCC12CCNCC2>>O=C1N(c2ccc(OC(F)(F)F)cc2)CCC12CCN(c1ccccc1F)CC2",
        "output": "294"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COc1cc(C(O)(C(F)(F)F)C(F)(F)F)ccc1CCC(=O)O.Cc1ccccc1.O=S(=O)(O)O>>COC(=O)CCc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1OC",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)C(=O)c1ccc(Cn2nc(C(F)(F)F)c3c2CCN(C(=O)OC(C)(C)C)C3)cc1.ClCCl.O=C(O)C(F)(F)F>>CCN(CC)C(=O)c1ccc(Cn2nc(C(F)(F)F)c3c2CCNC3)cc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.Nc1ccccc1C(=O)c1cccc(Cl)c1.O=[N+]([O-])c1cccnc1Cl>>O=C(c1cccc(Cl)c1)c1ccccc1Nc1ncccc1[N+](=O)[O-]",
        "output": "434"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1[nH]cnc1-c1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1[nH]cnc1-c1ccccc1",
        "output": "286"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "OB(O)c1cccnc1.Oc1cccc(-c2ccc3c(Br)c(O)ccc3c2)c1>>Oc1cccc(-c2ccc3c(-c4cccnc4)c(O)ccc3c2)c1",
        "output": "899"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C1COCCOCCOCCOCCO1.Cc1ccc(Oc2ccc(Nc3ncnc4cccc(F)c34)cc2C)cn1.OC[C@H]1CCCN1.[H-].[Na+]>>Cc1ccc(Oc2ccc(Nc3ncnc4cccc(OC[C@H]5CCCN5)c34)cc2C)cn1",
        "output": "958"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCCCCCCc1ccc2c(c1)CCC(C(CO)(CO)NC(C)=O)C2.CCCCCCCCc1ccc2c(c1)CCC(C(CO)NC(C)=O)C2.CCOC(C)=O.CO.O.[Li+].[OH-]>>CCCCCCCCc1ccc2c(c1)CCC(C(N)(CO)CO)C2",
        "output": "412"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(=O)CC1.CCCCCC.CCCCCCC.CCCC[Mg]CCCC.O=C(O)C1(c2ccc(Br)cc2)CC1.[Li]CCCC>>CC(C)(C)OC(=O)N1CCC(O)(c2ccc(C3(C(=O)O)CC3)cc2)CC1",
        "output": "321"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCN1CCC(C)CC1.CC(=O)[O-].CC(=O)[O-].CCNCC.Cc1ccccc1C(=O)P(C(=O)c1ccccc1C)C(=O)c1ccccc1C.Fc1cccc(I)c1.[Cu]I.[Pd+2]>>CC1CCN(CC#Cc2cccc(F)c2)CC1",
        "output": "664"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOc1cc(C(CC(=O)O)N2Cc3cccc(NC(=O)C4CC4)c3C2=O)ccc1OC(F)F.Cl.NO.O=C(n1ccnc1)n1ccnc1>>CCOc1cc(C(CC(=O)NO)N2Cc3cccc(NC(=O)C4CC4)c3C2=O)ccc1OC(F)F",
        "output": "480"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCN(CC1CCOC1)C(=C[N+](=O)[O-])SC.CCN>>CCCN(CC1CCOC1)C(=C[N+](=O)[O-])NCC",
        "output": "270"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC1(c2ncc(Sc3ccc(C(C)=O)cc3)s2)CCOC1C.Cl.NO>>COC1(c2ncc(Sc3ccc(/C(C)=N/O)cc3)s2)CCOC1C",
        "output": "212"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCOC(=O)COc1cc(N)c(F)cc1Cl.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.O=C1OC(=O)C2=C1CCCC2>>CCCCCOC(=O)COc1cc(N2C(=O)C3=C(CCCC3)C2=O)c(F)cc1Cl",
        "output": "410"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)CCc1ccc2c(c1)C(=O)c1ccccc1-2.CO.O.[Na+].[OH-]>>CC(O)CCc1ccc2c(c1)C(=O)c1ccccc1-2",
        "output": "325"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)CCC(=O)N1CCc2cc(S(=O)(=O)Cl)ccc21.Cl.ClCCl.Fc1ccc(N2CCNCC2)cc1.O.c1ccncc1>>COC(=O)CCC(=O)N1CCc2cc(S(=O)(=O)N3CCN(c4ccc(F)cc4)CC3)ccc21",
        "output": "99"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCBr.CN(C)C=O.Cc1ccc(O)c(Cl)c1.O.O=C([O-])[O-].[K+].[K+]>>C=CCOc1ccc(C)cc1Cl",
        "output": "77"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCOCC1.COc1ccc(COC(=O)[C@H](CC(=O)OC(C)(C)C)O/N=C(\\C(=O)O)c2nc(NC(=O)OC(C)(C)C)sc2Cl)cc1.Cl.ClCCl.N[C@@H]1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(CCl)CS[C@H]12.O=P(Cl)(Cl)Oc1ccccc1>>COc1ccc(COC(=O)[C@H](CC(=O)OC(C)(C)C)O/N=C(\\C(=O)N[C@@H]2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(CCl)CS[C@H]23)c2nc(NC(=O)OC(C)(C)C)sc2Cl)cc1",
        "output": "587"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C(=O)OC(C)(C)C)C1CCN(Cc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>CNC1CCN(Cc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)CC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCOC(=O)c1ccc(N2CCN(Cc3ccccc3-c3ccc(Cl)cc3)CC2)cc1.O>>O=C(O)c1ccc(N2CCN(Cc3ccccc3-c3ccc(Cl)cc3)CC2)cc1",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cc(C2CC2)cnc1N1CCNCC1.Cc1cc(N2CCCS2(=O)=O)ccc1C(=O)O.Cl>>Cc1cc(N2CCCS2(=O)=O)ccc1C(=O)N1CCN(c2ncc(C3CC3)cc2C)CC1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)CCN.CO.NC(=O)c1cnc(Oc2ccc(C=O)cc2)cn1.[BH4-].[Na+]>>CC(C)CCNCc1ccc(Oc2cnc(C(N)=O)cn2)cc1",
        "output": "468"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(O[Si](C)(C)C)c1cccc(Br)c1.CCC(CC)(c1ccc(OC[C@H]2CCC(=O)O2)c(C)c1)c1ccc(B2OC(C)(C)C(C)(C)O2)c(C)c1.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].[Na+].[Na+]>>CCC(CC)(c1ccc(OC[C@H]2CCC(=O)O2)c(C)c1)c1ccc(-c2cccc(C(O[Si](C)(C)C)C(C)(C)C)c2)c(C)c1",
        "output": "933"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)C(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3cc(O)cc(N4CCCC4)c3)nc12.CC(C)OC(=O)N=NC(=O)OC(C)C.CSCCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CSCCOc1cc(-c2cnc3c(n2)c(C(=O)C(C)(C)C)cn3COCC[Si](C)(C)C)cc(N2CCCC2)c1",
        "output": "550"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)c1ccncc1.COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(-c2ccc(C(=O)O)[nH]2)c1.ClCCl.NCCSC(c1ccccc1)(c1ccccc1)c1ccccc1>>COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(-c2ccc(C(=O)NCCSC(c3ccccc3)(c3ccccc3)c3ccccc3)[nH]2)c1",
        "output": "137"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Nc1ccc2cnn(CCN3CCCC3)c2c1.O=C(O)Cc1ccc(Oc2ccccc2)cc1>>O=C(Cc1ccc(Oc2ccccc2)cc1)Nc1ccc2cnn(CCN3CCCC3)c2c1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN1CCOCC1.CCN=C=NCCCN(C)C.Cl.ClCCl.NCc1ccc(F)cc1Cl.O=C(O)Cc1cnn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c1.On1nnc2ccccc21>>O=C(Cc1cnn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c1)NCc1ccc(F)cc1Cl",
        "output": "599"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCC.CN(C)C=O.Fc1cccc(F)n1.O.O=C([O-])[O-].O=S(=O)([O-])[O-].Oc1ccc(C(F)(F)F)cc1.[K+].[K+].[Mg+2]>>Fc1cccc(Oc2ccc(C(F)(F)F)cc2)n1",
        "output": "727"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Oc1ccc(-c2cnc[nH]c2=O)cc1OC(C)=O.O=P(Cl)(Cl)Cl>>CC(=O)Oc1ccc(-c2cncnc2Cl)cc1OC(C)=O",
        "output": "14"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1onc(-c2ccccc2)c1CNc1ccc(C(=O)O)cn1.F[B-](F)(F)F.NCCO>>Cc1onc(-c2ccccc2)c1CNc1ccc(C(=O)NCCO)cn1",
        "output": "674"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(C)=O.CCc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1NC(=O)c1ccc(CNC(=O)OC(C)(C)C)c(C)c1.Cl.O.O=C([O-])O.[Na+]>>CCc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1NC(=O)c1ccc(CN)c(C)c1",
        "output": "793"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)c1ccc(NS(C)(=O)=O)cc1.O.[Na+].[OH-]>>CS(=O)(=O)Nc1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COCOc1cccnc1C(O)c1cccc(Br)c1.O=C(OO)c1cccc(Cl)c1.O=S([O-])[O-].[Na+].[Na+]>>COCOc1ccc[n+]([O-])c1C(O)c1cccc(Br)c1",
        "output": "262"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCC(=O)Cl.Fc1ccc2ccccc2c1>>CCCC(=O)c1cccc2ccc(F)cc12",
        "output": "31"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.CCOC(=O)c1c(OCc2ccccc2)c(OCc2ccccc2)c(C(=O)N(C)C)n1-c1ccc(O)cc1.CSCCCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1c(OCc2ccccc2)c(OCc2ccccc2)c(C(=O)N(C)C)n1-c1ccc(OCCCSC)cc1",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCOC(=O)CCCCCBr.Cc1cccnc1[C@@H]1CCC[C@H](c2ncccc2C)N1>>CCOC(=O)CCCCCN1[C@H](c2ncccc2C)CCC[C@@H]1c1ncccc1C",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.COC(=O)c1ccc2c(c1)CC[C@H]2N.Cl.ClCCl.O=S(=O)(Cl)c1ccccc1Cl>>COC(=O)c1ccc2c(c1)CC[C@H]2NS(=O)(=O)c1ccccc1Cl",
        "output": "530"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1cccc(Br)n1.CN(C)C=O.OCc1ccccc1.[H-].[Na+]>>Brc1cccc(OCc2ccccc2)n1",
        "output": "551"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCNCc1ccccc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O=C(O)Cc1ccc(O)c(F)c1>>CCCCCCN(Cc1ccccc1)C(=O)Cc1ccc(O)c(F)c1",
        "output": "633"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)C(c1ccccc1)C(C)C.O.[Na+].[OH-]>>CC(C)C(C(=O)O)c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(=O)(=O)Cl.O=C1N(c2ccc(OC(F)(F)F)cc2)CCC12CCNCC2>>CS(=O)(=O)N1CCC2(CCN(c3ccc(OC(F)(F)F)cc3)C2=O)CC1",
        "output": "584"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(=O)Cl.CN(C)CCc1ccccc1.O.S=C=S.[Al+3].[Cl-].[Cl-].[Cl-].[Na+].[OH-]>>CCC(=O)c1ccc(CCN(C)C)cc1",
        "output": "31"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CCCCCCBr.CN(C)C=O.CNCCNC(=O)C(F)(F)F.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CCCCCCN(C)CCNC(=O)C(F)(F)F",
        "output": "73"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.C1COCCO1.CCOC(C)=O.COCOc1ccc(-c2ccc3c(c2CNc2ccccc2OC)C(C)=CC(C)(C)N3)c(OC)c1.Cl>>COc1ccccc1NCc1c(-c2ccc(O)cc2OC)ccc2c1C(C)=CC(C)(C)N2",
        "output": "755"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COc1ccc(C(=O)Cl)cc1OC1CC=CC1.COc1ccc(C(=O)O)cc1OC1CC=CC1.Nc1c(Cl)cncc1Cl.O=C([O-])[O-].[H-].[K+].[K+].[Na+]>>COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)cc1OC1CC=CC1",
        "output": "11"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCS.COc1ccc2c(C(=O)c3ccc(OCCN4CCCCC4)cc3)c(-c3ccc(OC)c(F)c3)sc2c1.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)c(F)c2)sc2cc(O)ccc12",
        "output": "20"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(C)=O.O=C([O-])[O-].OCCCCl.Oc1ccc(-n2ccnc2)cc1.[K+].[K+]>>OCCCOc1ccc(-n2ccnc2)cc1",
        "output": "74"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCO.CCOC(=O)C(C(=O)OCC)C1CN(C(=O)OCc2ccccc2)C1.[K+].[OH-]>>CCOC(=O)C(C(=O)O)C1CN(C(=O)OCc2ccccc2)C1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N1CCC(CCC(=O)O)CC1.O=C1CCc2cccc3c2N1CCC3>>CC(=O)N1CCC(CCC(=O)c2cc3c4c(c2)CCC(=O)N4CCC3)CC1",
        "output": "435"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccccn1.C#CCCn1nc(C)c(-c2ccc(F)cc2)n1.c1ccncc1>>Cc1nn(CCC#Cc2ccccn2)nc1-c1ccc(F)cc1",
        "output": "777"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc(COC(CCc2ccc(I)cc2)C(CCO[Si](C)(C)C(C)(C)C)C(=O)OC(C)(C)C)cc1.[F-]>>COc1ccc(COC(CCc2ccc(I)cc2)C(CCO)C(=O)OC(C)(C)C)cc1",
        "output": "708"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCC.COC(COc1ccc(Br)cc1C)OC.Cl.[Cl-].[Na+]>>Cc1cc(Br)ccc1OCC=O",
        "output": "234"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCc1ccc2c(C)c(Cc3ccccc3[N+](=O)[O-])c(=O)n(Cc3ccc(-c4ccccc4-c4nnn[nH]4)cc3)c2c1>>CCc1ccc2c(C)c(Cc3ccccc3N)c(=O)n(Cc3ccc(-c4ccccc4-c4nnn[nH]4)cc3)c2c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COC(=O)c1ccc[nH]c1=O.Cl.ClCCC(c1ccccc1)c1ccccc1.[H-].[Na+]>>COC(=O)c1cccn(CCC(c2ccccc2)c2ccccc2)c1=O",
        "output": "42"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCCC(c2ccc(F)c(O)c2)C1.CC(C)=O.COCCBr.O=C([O-])[O-].[K+].[K+]>>COCCOc1cc(C2CCCN(C(=O)OC(C)(C)C)C2)ccc1F",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(Cl)OC(=O)Cl.CCN(C(C)C)C(C)C.COc1c(C(=O)NC2CCN(Cc3ccccc3)CC2C)n(C)c2c1c(=O)n(CC(=O)c1ccccc1)c1ccccc21>>COc1c(C(=O)NC2CCNCC2C)n(C)c2c1c(=O)n(CC(=O)c1ccccc1)c1ccccc21",
        "output": "84"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)[Mg]Cl.CCOCC.CN(C)C=O.Cl.O=C(O)c1cc(Br)cc(S(F)(F)(F)(F)F)c1>>O=Cc1cc(C(=O)O)cc(S(F)(F)(F)(F)F)c1",
        "output": "638"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)/C(C)=C/CCC#Cc1ccccc1.O.[K+].[OH-]>>C/C(=C\\CCC#Cc1ccccc1)C(=O)O",
        "output": "122"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCNC(=O)Nc1cc(Cl)ccn1.CN(C)C=O.O.O=C1CCC(=O)N1Br>>CCNC(=O)Nc1cc(Cl)c(Br)cn1",
        "output": "518"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COc1cc(C(=O)[C@@H](C)NC(=O)OC(C)(C)C)ccc1SC.[BH4-].[Na+]>>COc1cc(C(O)[C@@H](C)NC(=O)OC(C)(C)C)ccc1SC",
        "output": "24"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(c1ccccc1C(F)(F)F)N1CCN(c2ccc(Cl)nn2)CC1.OCCC1CC1.OCCc1ccccc1>>O=C(c1ccccc1C(F)(F)F)N1CCN(c2ccc(OCCC3CC3)nn2)CC1",
        "output": "407"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CC[C@@H]1NC(=O)C[C@]1(C)O.N#Cc1ccc(Br)cc1Cl.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>CC[C@@H]1N(c2ccc(C#N)c(Cl)c2)C(=O)C[C@]1(C)O",
        "output": "809"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)[C@@H](N)Cc1ccc(OC)c(OC)c1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>COc1ccc(C[C@H](N)CO)cc1OC",
        "output": "343"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CNc1ccc(S(C)(=O)=O)cc1[N+](=O)[O-].[Pd]>>CNc1ccc(S(C)(=O)=O)cc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.FC(F)COc1ccccc1.O=C(Cl)c1cc(Br)ccc1Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(c1ccc(OCC(F)F)cc1)c1cc(Br)ccc1Cl",
        "output": "61"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCCCc1ccc(-c2ccc(C(=O)O)cc2)cc1.CS(N)(=O)=O.O=S(Cl)Cl.c1ccncc1>>CCCCCCCCc1ccc(-c2ccc(C(=O)NS(C)(=O)=O)cc2)cc1",
        "output": "580"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCO.CCN.CCN(C(C)C)C(C)C.Nc1nc(Cl)cc(Cl)n1>>CCNc1cc(Cl)nc(N)n1",
        "output": "166"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC1(C)OB(c2ccc(-c3nc4c(cc3Cl)nc(O[C@@H]3CO[C@@H]5[C@H](O)CO[C@@H]53)n4COCC[Si](C)(C)C)cc2)OC1(C)C.CN=S(=O)(NC)c1ccc(Br)cc1>>CN=S(=O)(NC)c1ccc(-c2ccc(-c3nc4c(cc3Cl)nc(O[C@@H]3CO[C@@H]5[C@H](O)CO[C@@H]53)n4COCC[Si](C)(C)C)cc2)cc1",
        "output": "933"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.COc1c(OC(F)F)ccc(-c2cccc3c2CCC3=O)c1O.O=C([O-])[O-].OCC1(CBr)COC1.[K+].[K+]>>COc1c(OC(F)F)ccc(-c2cccc3c2CCC3=O)c1OCC1(CO)COC1",
        "output": "75"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.O.O=[N+]([O-])c1ccc(CN(Cc2ccccn2)S(=O)(=O)c2ccc(Cl)cc2)cc1.[Cl-].[Fe].[NH4+]>>Nc1ccc(CN(Cc2ccccn2)S(=O)(=O)c2ccc(Cl)cc2)cc1",
        "output": "507"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NCCCCCCO.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CC(C)(C)OC(=O)NCCCCCC=O",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(Cc1cc(Br)ccc1OCC1CCCC1)c1ccc(C(=O)OC)cn1.CO.[Na+].[OH-]>>CCN(Cc1cc(Br)ccc1OCC1CCCC1)c1ccc(C(=O)O)cn1",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CC(O)c1c(C)noc1-c1ccc(Br)cc1.CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1>>C=CC(O)c1c(C)noc1-c1ccc(-c2ccc(C3(C(=O)OCC)CC3)cc2)cc1",
        "output": "933"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CI.Cc1cc2[nH]ncc2cc1Br.O.[H-].[Na+]>>Cc1cc2c(cnn2C)cc1Br",
        "output": "229"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(C)=O.COCOc1c(C2CCCCC2)ccc(B(O)O)c1F.Nc1ncc(Br)cn1.O=C([O-])[O-].[Na+].[Na+]>>COCOc1c(C2CCCCC2)ccc(-c2cnc(N)nc2)c1F",
        "output": "871"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CN)c1.O=C(O)c1ccc(Br)cc1>>Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2ccc(Br)cc2)c1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#CC.CCN(CC)CC.CCOC(=O)c1cc(Br)cnc1C(=O)OCC.CS(C)=O.Cl[Pd]Cl.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC#Cc1cnc(C(=O)OCC)c(C(=O)OCC)c1",
        "output": "719"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CN1CCc2nc(N)sc2C1.N#Cc1cccc(NC(=O)COc2cccc(C(=O)O)c2)c1.O>>CN1CCc2nc(NC(=O)c3cccc(OCC(=O)Nc4cccc(C#N)c4)c3)sc2C1",
        "output": "918"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C1(C(=O)OCC)CC(OCc2ccccc2)C1.[Pd]>>CCOC(=O)C1(C(=O)OCC)CC(O)C1",
        "output": "178"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CI.CN(C)c1ccc(Br)c(CO)c1.[H-].[Na+]>>COCc1cc(N(C)C)ccc1Br",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)C=Cc1c(-c2ccccc2)nn2ccccc12.[Na+].[OH-]>>O=C(O)C=Cc1c(-c2ccccc2)nn2ccccc12",
        "output": "58"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1ccc(Br)cc1.COc1ccccc1-c1ccc(Br)cc1.OB(O)c1ccccc1>>Brc1ccc(-c2ccccc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1(C)c2ccccc2-c2cc3c(cc21)[nH]c1ccc(Br)cc13.CN(C)c1ccncc1.O>>CC(C)(C)OC(=O)n1c2ccc(Br)cc2c2cc3c(cc21)C(C)(C)c1ccccc1-3",
        "output": "748"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(=O)(=O)c1nccc(Oc2ccc(NC(=O)c3cc(F)cc(N4CCCCC4)c3)c3ccccc23)n1.OCC1CCNCC1>>O=C(Nc1ccc(Oc2ccnc(N3CCC(CO)CC3)n2)c2ccccc12)c1cc(F)cc(N2CCCCC2)c1",
        "output": "679"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCOC(C)=O.COc1ccc2ncc(=O)n(CCC3(O)CCC4(CC3)OCCO4)c2c1.O=C(O)C(F)(F)F.O=C([O-])O.[Cl-].[Na+].[Na+]>>COc1ccc2ncc(=O)n(CCC3(O)CCC(=O)CC3)c2c1",
        "output": "251"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cn(C(CC2CCC2)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1C#N.Nc1ccc(-c2c[nH]c(=O)o2)cc1>>COc1cn(C(CC2CCC2)C(=O)Nc2ccc(-c3c[nH]c(=O)o3)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C(=O)O)CCC1.CCN(C(C)C)C(C)C.CCOC(=O)c1ccc2c(c1)OCCN[C@@H]2C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F>>CCOC(=O)c1ccc2c(c1)OCCN(C(=O)C1(C)CCC1)[C@@H]2C",
        "output": "633"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C(C)COC)c2nc(C)nn12.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(C(C)COC)c2nc(C)nn12",
        "output": "979"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1cccc(C(C)(C)C)n1.COC(=O)C12CCC(O)(CC1)C2.ClCCl.ClCc1ccccc1Oc1ccccc1.O=S(=O)([O-])C(F)(F)F.[Ag+]>>COC(=O)C12CCC(OCc3ccccc3Oc3ccccc3)(CC1)C2",
        "output": "208"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.COc1cccc(P(=O)(c2ccccc2)c2ccccc2)c1.ClCCl>>O=P(c1ccccc1)(c1ccccc1)c1cccc(O)c1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(Cl)Cl.CCOC(=O)c1ccc[nH]1.NC(CO)(CO)CO.O=C(Cl)Cc1ccc(Cl)cc1.[Al+3].[Cl-].[Cl-].[Cl-]>>CCOC(=O)c1cc(C(=O)Cc2ccc(Cl)cc2)c[nH]1",
        "output": "524"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)CN1CCCC1.Cl>>O=C(O)CN1CCCC1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)c1ccc([N+](=O)[O-])cc1O.CI.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>COc1cc([N+](=O)[O-])ccc1C(C)(C)C",
        "output": "62"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(c1ccccc1-c1ccccc1)C(C)(C)C.CC(C)(C)[O-].CCN(CC)C(=O)COc1ccc(Cl)cc1.O=C(N[C@H]1CCCNC1)C12CC3CC(C1)C(O)C(C3)C2.[Na+].[Pd+2]>>CCN(CC)C(=O)COc1ccc(N2CCC[C@H](NC(=O)C34CC5CC(C3)C(O)C(C5)C4)C2)cc1",
        "output": "105"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(OC(c2cc(-c3ccccc3)oc2C)C2CCC2)cc1.Cl.O.[Li+].[OH-]>>Cc1oc(-c2ccccc2)cc1C(Oc1ccc(C(=O)O)cc1)C1CCC1",
        "output": "222"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C(On1nnc2ccc(Cl)cc21)=[N+](C)C.CN(C)C=O.CN(C)c1ccncc1.C[C@H]1CNC[C@@H](C)O1.F[P-](F)(F)(F)(F)F.NC(=O)c1cc(Br)cc2c1[nH]c1cc(C(=O)O)ccc12.O.[Cl-].[Li+]>>C[C@H]1CN(C(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)cc(Br)cc23)C[C@@H](C)O1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3-c3ccccc3)CC2)c(F)c1.CO.CON.Cl.c1ccncc1>>CO/N=C(\\C)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3-c3ccccc3)CC2)c(F)c1",
        "output": "212"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Br.CCN(CC)CCBr.CO.O=C([O-])[O-].OCCS.[Na+].[Na+]>>CCN(CC)CCSCCO",
        "output": "185"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1.CS(=O)(=O)N1CCC(c2ncc(-c3ccc(N)cc3)s2)CC1.O=C=Nc1ccccc1F>>CS(=O)(=O)N1CCC(c2ncc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)s2)CC1",
        "output": "473"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#Cc1ccc(C(=O)OC(C)(C)C)cc1.CC#N.CCN(CC)CC.CCOC(=O)c1ccc(-c2ccc(Br)cc2)cc1.[Cu]I.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1ccc(-c2ccc(C#Cc3ccc(C(=O)OC(C)(C)C)cc3)cc2)cc1",
        "output": "659"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1c(C)noc1C(=O)N1CCCCC1.O.[Na+].[OH-]>>Cc1noc(C(=O)N2CCCCC2)c1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1CN(Cc2cc([N+](=O)[O-])cc3ccoc23)CCN1.CCN(CC)CC.ClCCl.O=C([O-])[O-].[Na+].[Na+]>>CC1CN(Cc2cc([N+](=O)[O-])cc3ccoc23)CCN1C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)OCCOc1ccc([N+](=O)[O-])cc1F.CCOC(C)=O.[Pd]>>CC(C)(C)[Si](C)(C)OCCOc1ccc(N)cc1F",
        "output": "202"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1ccccc1-c1nc(Cl)c2cc(F)ccc2n1.ClCCl>>Oc1ccccc1-c1nc(Cl)c2cc(F)ccc2n1",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.C=CCc1cc(Cl)cc2nc(Cc3ccccc3Cl)oc12.CC(C)CCBCCC(C)C.CC=C(C)C.ClCCl.O.OO.[Na+].[OH-]>>OCCCc1cc(Cl)cc2nc(Cc3ccccc3Cl)oc12",
        "output": "465"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(O)C1CCCCC1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CCC(OS(C)(=O)=O)C1CCCCC1",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCCOc1nc(N)c2[nH]c(=O)n(CCCNCCN(C)C)c2n1.CN1CCCC1=O.COC(=O)Cc1cccc(C=O)c1.ClCCCl.[Na+]>>CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(CCN(C)C)Cc3cccc(CC(=O)OC)c3)c2n1",
        "output": "567"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCO.CCOC(=O)C1CCC(N)CC1.CS(=O)c1nccc(-n2nnc3c(I)cccc32)n1>>CCOC(=O)C1CCC(Nc2nccc(-n3nnc4c(I)cccc43)n2)CC1",
        "output": "666"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)O.CC1Cc2cc(C#N)ccc2N(c2ccccc2)CCO1.CCOC(C)=O.CO.O.[Cl-].[K+].[Na+].[OH-]>>CC1Cc2cc(C(N)=O)ccc2N(c2ccccc2)CCO1",
        "output": "419"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cn1cc(CCO)cn1.O=S(Cl)Cl>>Cn1cc(CCCl)cn1",
        "output": "96"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COc1cc(C(=O)O)c2c(c1OC)CCCC2.ClCCl.O=C(Cl)C(=O)Cl>>COc1cc(C(=O)Cl)c2c(c1OC)CCCC2",
        "output": "448"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.C[N+](=O)[O-].O=Cc1ccccc1Cl.[Na+].[OH-]>>O=[N+]([O-])C=Cc1ccccc1Cl",
        "output": "282"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(O)nc(C)c1C#N.O.O=S(=O)(O)O.O=[N+]([O-])O.[Na+].[OH-]>>Cc1nc(O)c([N+](=O)[O-])c(C)c1C#N",
        "output": "328"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1C[C@@H]2O[C@@H]2[C@H]1C(=O)OCc1ccccc1.CCOC(C)=O.[OH-].[OH-].[Pd+2]>>CC(C)(C)OC(=O)N1C[C@@H]2O[C@@H]2[C@H]1C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)C=O.O.OCCCc1nc2ccccc2[nH]1>>CC(C)(C)[Si](C)(C)OCCCc1nc2ccccc2[nH]1",
        "output": "193"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)O.CCOC(C)=O.Clc1nccc(-c2c[nH]nc2-c2cccc(OCc3ccccc3)c2)n1.Nc1ccc(C(=O)O)cc1>>O=C(O)c1ccc(Nc2nccc(-c3c[nH]nc3-c3cccc(OCc4ccccc4)c3)n2)cc1",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CI.CN(C)C=O.O.O=C1NCCc2[nH]c3c(F)cccc3c21.[H-].[Na+]>>Cn1c2c(c3cccc(F)c31)C(=O)NCC2",
        "output": "191"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)C(=O)Cl.CN(C)C=O.Cc1ccc2c(c1)c1c(n2CC(C)(O)c2cccnc2)CCN(C)C1.[H-].[Na+]>>Cc1ccc2c(c1)c1c(n2CC(C)(OC(=O)C(C)(C)C)c2cccnc2)CCN(C)C1",
        "output": "126"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)C1CCCN(COS(C)(=O)=O)c2c1cc(OCc1ccccc1)c1ccccc21.[Pd]>>CC(C)(C)OC(=O)C1CCCN(COS(C)(=O)=O)c2c1cc(O)c1ccccc21",
        "output": "698"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CCOc1ccc(C(=O)c2cc(I)ccc2Cl)cc1.CC[SiH](CC)CC.COC(C)(C)C.O=C([O-])O.[Na+]>>CCOc1ccc(Cc2cc(I)ccc2Cl)cc1",
        "output": "181"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)NC(=O)c1ccc2n1CCNC2.O=C(O)c1cc2ncc(Br)cn2n1>>CC(C)NC(=O)c1ccc2n1CCN(C(=O)c1cc3ncc(Br)cn3n1)C2",
        "output": "663"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(C)=O.N#Cc1cc([N+](=O)[O-])ccc1Cl.O.Oc1ccc(Cl)cc1Cl.[Na+].[OH-]>>N#Cc1cc([N+](=O)[O-])ccc1Oc1ccc(Cl)cc1Cl",
        "output": "299"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(C)=O.CI.CN(C)C=O.O=C(O)C(CCc1ccc(Cl)cc1)(Cn1cncn1)c1ccccc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)C(CCc1ccc(Cl)cc1)(Cn1cncn1)c1ccccc1",
        "output": "415"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.COC(=O)c1nc2c(C(F)(F)F)cc(C#C[Si](C)(C)C)cn2c1Cl.[F-]>>C#Cc1cc(C(F)(F)F)c2nc(C(=O)OC)c(Cl)n2c1",
        "output": "337"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)C1(Sc2ccnc3ccc(C#N)cc23)CCC1.Cl.ClCCl.O.O.[Li+].[OH-]>>N#Cc1ccc2nccc(SC3(C(=O)O)CCC3)c2c1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)CCC(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1.Cl>>O=C(O)CCC(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)n1cc(C=O)c2cccnc21.CCO.[BH4-].[Na+]>>CC(C)(C)OC(=O)n1cc(CO)c2cccnc21",
        "output": "476"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cc1ncc[nH]1.O=C([O-])[O-].O=C1c2ccccc2C(=O)N1CCBr.[K+].[K+]>>Cc1nccn1CCN1C(=O)c2ccccc2C1=O",
        "output": "276"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Cc1ccc(S(=O)(=O)OCCCN2CCOCC2)cc1.NC(=O)c1sc(-n2cnc3ccc(O)cc32)nc1-c1cccc(Cl)c1.O=C([O-])[O-].[Cs+].[Cs+]>>NC(=O)c1sc(-n2cnc3ccc(OCCCN4CCOCC4)cc32)nc1-c1cccc(Cl)c1",
        "output": "438"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CI.CN(C)C=O.O.O=C(O)c1cccc([N+](=O)[O-])c1Br.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cccc([N+](=O)[O-])c1Br",
        "output": "415"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)c1ncccc1S(=O)(=O)c1ccc(/C=C/c2ccc(F)cc2)cc1.O.[Li+].[Na+].[OH-].[OH-]>>O=C(O)c1ncccc1S(=O)(=O)c1ccc(/C=C/c2ccc(F)cc2)cc1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CN(C)C(=O)Cl.CN(C)C=O.NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1OCCC1CCCCN1>>CN(C)C(=O)N1CCCCC1CCOc1cc(F)cc(Nc2ccc(I)cc2F)c1C(N)=O",
        "output": "258"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)Cc1cccc(O)c1.COCCl.O.[H-].[Na+]>>CCOC(=O)Cc1cccc(OCOC)c1",
        "output": "375"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N[C@@H](Cc1ccc(N)cc1)[C@H]1CN(C2(c3cccc(C(C)C)c3)CC2)C(=O)O1.CC(C)O.Cl.Fc1ccc(-c2cc(Cl)ncn2)cc1>>CC(=O)N[C@@H](Cc1ccc(Nc2cc(-c3ccc(F)cc3)ncn2)cc1)[C@H]1CN(C2(c3cccc(C(C)C)c3)CC2)C(=O)O1",
        "output": "161"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)CCCc1nc(Cl)c(C#N)cc1C(=O)OCC.O=C(NS(=O)(=O)Cc1ccccc1)C1CCNCC1>>CCOC(=O)CCCc1nc(N2CCC(C(=O)NS(=O)(=O)Cc3ccccc3)CC2)c(C#N)cc1C(=O)OCC",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCC(=O)Cl.COc1ccc(F)cc1C(=O)c1cnc(NC2CCNCC2)nc1N.O=C(O)C(F)(F)F>>CCCC(=O)N1CCC(Nc2ncc(C(=O)c3cc(F)ccc3OC)c(N)n2)CC1",
        "output": "125"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C=CCC[C@@H](C)O[C@@H](CC)[C@H](NC(=O)OC(C)(C)C)C(=O)OC.CO.Cl.[Li+].[OH-]>>C=CCC[C@@H](C)O[C@@H](CC)[C@H](NC(=O)OC(C)(C)C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)[C@H](NS(=O)(=O)c1ccc2oc3cc(-c4nccs4)ccc3c2c1)C(C)C.O.O.[Li+].[OH-]>>CC(C)[C@@H](NS(=O)(=O)c1ccc2oc3cc(-c4nccs4)ccc3c2c1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccccc1.ClCCl.NC1CC1.O=S(=O)([O-])[O-].[BH4-].[Mg+2].[Na+]>>CC(NC1CC1)c1ccccc1",
        "output": "693"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccc4c(=O)n(C)n(C)c4c3)sc2c1-c1ccc(Cl)cc1.CO.[Na+].[OH-]>>Cc1cc2nc(-c3ccc4c(=O)n(C)n(C)c4c3)sc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cl.ClCCl.NO.O=Cc1cc([N+](=O)[O-])ccc1O.c1ccncc1>>O=[N+]([O-])c1ccc(O)c(C=NO)c1",
        "output": "30"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN1CCCc2c1c1cc(OC3CCNCC3)ccc1[nH]c2=O.CO.ClC(Cl)Cl.ClCCl.[Na+].[Na+].[OH-]>>CN1CCC(Oc2ccc3[nH]c(=O)c4c(c3c2)N(C)CCC4)CC1",
        "output": "217"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCc1nn(-c2ccc(C#N)c(Cl)c2)c(CC)c1Cc1ccc(C(=O)OC)cc1.CO.O.[Li+].[OH-]>>CCc1nn(-c2ccc(C#N)c(Cl)c2)c(CC)c1Cc1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.O=[N+]([O-])c1ccc(N2CCC(CO)CC2)cc1.[Pd]>>Nc1ccc(N2CCC(CO)CC2)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(=O)c1nc(-c2ccc(Cl)cc2)n(-c2ccccc2Cl)c1CC=O.ClCCCl.NC1CCCC1.[Na+]>>CCOC(=O)c1nc(-c2ccc(Cl)cc2)n(-c2ccccc2Cl)c1CCNC1CCCC1",
        "output": "426"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.COc1ccc([C@@H](O)Cc2c(Cl)c[n+]([O-])cc2Cl)cc1OC.Cl.ClCCl.O.O=C(O)c1ccc(CC2OCCO2)cc1>>COc1ccc([C@H](Cc2c(Cl)c[n+]([O-])cc2Cl)OC(=O)c2ccc(CC3OCCO3)cc2)cc1OC",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)C(=O)Cl.COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCC(N)CC4)cc3)nc2c1.[Na+].[OH-]>>COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCC(NC(=O)N(C)C)CC4)cc3)nc2c1",
        "output": "454"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@@H](C(OCCO)c2cccc(F)c2F)C1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O>>CC(C)(C)OC(=O)N1CCC[C@@H](C(OCCOS(C)(=O)=O)c2cccc(F)c2F)C1",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1cc(-c2cncc(C(=O)O)c2)c(C)[nH]c1=O.NCC1CC(c2ccncc2)=NO1>>CCc1cc(-c2cncc(C(=O)NCC3CC(c4ccncc4)=NO3)c2)c(C)[nH]c1=O",
        "output": "674"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.Nc1cccc2c1C[C@H](O)CC2.O=C(O)C1CCN(c2cccc(Cl)c2)CC1.On1nnc2ccccc21>>O=C(Nc1cccc2c1C[C@H](O)CC2)C1CCN(c2cccc(Cl)c2)CC1",
        "output": "365"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COCCBr.COc1cccc(C(=O)NC2CCN(Cc3ccc4ccc(O)cc4c3)CC2)c1.O.O=C([O-])[O-].[K+].[K+]>>COCCOc1ccc2ccc(CN3CCC(NC(=O)c4cccc(OC)c4)CC3)cc2c1",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)Cl.Cl.Nc1ccccc1Cl.c1ccncc1>>CCOC(=O)Nc1ccccc1Cl",
        "output": "102"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.COc1cnc2[nH]cc(I)c2c1.O.O=S(=O)(Cl)c1ccccc1.[H-].[Na+]>>COc1cnc2c(c1)c(I)cn2S(=O)(=O)c1ccccc1",
        "output": "354"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=[N+]([O-])c1cc(Br)ccc1Br.Oc1ccccc1F>>O=[N+]([O-])c1cc(Br)ccc1Oc1ccccc1F",
        "output": "238"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.CC1(C)[C@H](N)C[C@@H]1O.CCN(C(C)C)C(C)C.CSc1ncc(C#N)c(Cl)n1>>CSc1ncc(C#N)c(N[C@@H]2C[C@H](O)C2(C)C)n1",
        "output": "166"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(CCOCCN(C)S(N)(=O)=O)C(=O)COc1ccccc1-c1c(C2CCCCC2)c2ccc(C(=O)O)cc2n1C.COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccccc3OCC(=O)N(C)CCCCN(C)S(N)(=O)=O)n(C)c2c1>>CN(CCCCN(C)S(N)(=O)=O)C(=O)COc1ccccc1-c1c(C2CCCCC2)c2ccc(C(=O)O)cc2n1C",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cc(B(O)O)ccc1F.Nc1nc(N2CCN(C(=O)COc3ccc(Cl)cc3)CC2)c2nc(Cl)ccc2n1>>Cc1cc(-c2ccc3nc(N)nc(N4CCN(C(=O)COc5ccc(Cl)cc5)CC4)c3n2)ccc1F",
        "output": "865"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COc1cccc(Sc2c(C(C)C)nc(COCc3ccccc3)n2Cc2ccncc2)c1.Cl>>COc1cccc(Sc2c(C(C)C)nc(CO)n2Cc2ccncc2)c1",
        "output": "178"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.CON.Cl.ClCCCl.O=C(O)CCCCCCC(=O)c1ccc2ccccc2c1.On1nnc2ccccc21>>CONC(=O)CCCCCCC(=O)c1ccc2ccccc2c1",
        "output": "480"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(-c2cc(C3CCN(C(=O)N(C)O)CC3)n(CC(=O)OC(C)(C)C)c2-c2ccc(OC)cc2)cc1.C[Si](C)(C)OS(=O)(=O)C(F)(F)F.Cc1cccc(C)n1.Cl.ClCCl>>COc1ccc(-c2cc(C3CCN(C(=O)N(C)O)CC3)n(CC(=O)O)c2-c2ccc(OC)cc2)cc1",
        "output": "278"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(CF)(CF)C(=O)C(Oc1ccc(Cl)cc1)n1cncn1.CO.Cl.[BH4-].[Na+]>>CC(CF)(CF)C(O)C(Oc1ccc(Cl)cc1)n1cncn1",
        "output": "91"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCc1ccc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CO)C(C)C)cc1OCCCOC.CS(=O)(=O)Cl.ClCCl>>CCc1ccc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2COS(C)(=O)=O)C(C)C)cc1OCCCOC",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)O.CCN(C(C)C)C(C)C.Clc1ncnc(Cl)n1.Nc1cccc(CS(=O)(=O)C2CCCC2)c1>>O=S(=O)(Cc1cccc(Nc2ncnc(Cl)n2)c1)C1CCCC1",
        "output": "592"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC.CCCCCCCCC1(CCCCCCCC)c2ccccc2-c2ccc(C=O)cc21.CCOCC.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-].[Li]CCCC>>C=Cc1ccc2c(c1)C(CCCCCCCC)(CCCCCCCC)c1ccccc1-2",
        "output": "649"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClP(Cl)(Cl)(Cl)Cl.O=P(Cl)(Cl)Cl.Oc1ncc(I)cc1Cl>>Clc1cc(I)cnc1Cl",
        "output": "41"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccc(C2CC2)nc1.C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc(C3CC3)nc2)OC1(C)C",
        "output": "943"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1[nH]c(C=O)c(C)c1CCCN(C)C.O=C1Cc2cc(Br)ccc2N1>>Cc1[nH]c(C=C2C(=O)Nc3ccc(Br)cc32)c(C)c1CCCN(C)C",
        "output": "440"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O=Cc1cc(Cl)ccc1OCCC1CCOCC1.[BH4-].[Na+]>>OCc1cc(Cl)ccc1OCCC1CCOCC1",
        "output": "356"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)[Si](Cl)(C(C)C)C(C)C.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.OCCCN1CCC[C@H]1c1nnc2ccc(F)cn12>>CC(C)[Si](OCCCN1CCC[C@H]1c1nnc2ccc(F)cn12)(C(C)C)C(C)C",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COC(=O)COc1ccccc1Oc1cc(O)ccc1[N+](=O)[O-].FC(F)(F)c1cnc(Cl)c(Cl)c1.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)COc1ccccc1Oc1cc(Oc2ncc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-]",
        "output": "516"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cc(=O)c2cc(-c3ccc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)cc3)ccc2o1.ClCCl.O=C([O-])O.[Na+]>>CC(C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc(-c2ccc3oc(C(=O)O)cc(=O)c3c2)cc1",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCn1c(C)c(CCc2ccc(Cl)cc2)c2cc(O)ccc21.CCOC(=O)C(C)(C)Br>>CCCn1c(C)c(CCc2ccc(Cl)cc2)c2cc(OC(C)(C)C(=O)OCC)ccc21",
        "output": "305"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCN(c2ccc(C=O)cc2)CC1.FC(F)(F)c1nnc2ccc(N3CCNCC3)nn12>>CN1CCN(c2ccc(CN3CCN(c4ccc5nnc(C(F)(F)F)n5n4)CC3)cc2)CC1",
        "output": "567"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOP(=O)(CCN)OCC.CCOP(=O)(CCN)OCC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COCCNC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CC(=O)O)c1=O.F[P-](F)(F)(F)(F)F.O.O=C(O)C(=O)O>>CCOP(=O)(CCNC(=O)Cn1c(=O)c(C(=O)NCCOC)c(O)c2ncc(Cc3ccc(F)cc3)cc21)OCC",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N(C)C.CCN=C=NCCCN(C)C.CCOC(=O)c1oc(N2CC[C@H](N)[C@H](OC)C2)nc1C.CCc1[nH]c(C(=O)O)nc1Cl.Cl.ClCCl.On1nnc2ccccc21>>CCOC(=O)c1oc(N2CC[C@H](NC(=O)c3nc(Cl)c(CC)[nH]3)[C@H](OC)C2)nc1C",
        "output": "951"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.BrBr.CC(=O)O.CC(=O)c1cnc(N)c(Cl)c1>>Nc1ncc(C(=O)CBr)cc1Cl",
        "output": "173"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)CCO.C[Si](C)(C)[N-][Si](C)(C)C.N#Cc1ccc(Cl)nc1.[Na+]>>CC(C)(C)CCOc1ccc(C#N)cn1",
        "output": "433"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CO.COc1cc(C=O)cc(OC)c1.ClCCl.O=C1N(CCN2CCNCC2)CCC1(c1ccc(F)cc1)c1ccc(F)cc1>>COc1cc(CN2CCN(CCN3CCC(c4ccc(F)cc4)(c4ccc(F)cc4)C3=O)CC2)cc(OC)c1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "N#Cc1cccc(N)c1.O=C(O)c1ccc(-c2ccccc2)o1>>N#Cc1cccc(NC(=O)c2ccc(-c3ccccc3)o2)c1",
        "output": "860"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CON.Cl.Cl.O=C(NC(Cc1ccccc1)C(O)C(=O)O)c1cccnc1-n1cc2ccccc2n1>>CONC(=O)C(O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1cc2ccccc2n1",
        "output": "480"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.C1COCCO1.COC(=O)c1ccc2nc(-c3ccccc3)c(Br)nc2c1.COc1ccc(B(O)O)cc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>COC(=O)c1ccc2nc(-c3ccccc3)c(-c3ccc(OC)cc3)nc2c1",
        "output": "876"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)OCC(C)(C)C(C(=O)NCCC(=O)O)O1.Nc1ccccc1O>>CC1(C)OCC(C)(C)C(C(=O)NCCC(=O)Nc2ccccc2O)O1",
        "output": "365"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)C(C)c1ccc(N2CCNC2=O)cc1.O=C([O-])[O-].[Na+].[Na+]>>CC(C(=O)O)c1ccc(N2CCNC2=O)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C1CC(c2ccc(F)cc2)Oc2ccc(O)cc21.Oc1ccc2c(c1)C(O)CC(c1ccccc1)O2>>Oc1ccc2c(c1)C(O)CC(c1ccc(F)cc1)O2",
        "output": "24"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCN(CC(=O)OC(C)(C)C)Cc1ccccc1-3.ClCCl.O.O=C(O)C(F)(F)F>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCN(CC(=O)O)Cc1ccccc1-3",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCCCBr.CN(C)C=O.O=Cc1ccc(O)cc1.[H-].[Na+]>>CCCCCCCCOc1ccc(C=O)cc1",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)COc1ccc(C#N)cc1[N+](=O)[O-].[Pd]>>COC(=O)COc1ccc(C#N)cc1N",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCNC(=O)Nc1ccc(Oc2ccnc3cc(O)c(OC)cc23)cc1Cl.CN(C)C=O.Cl.ClCc1ccncc1.O.O=C([O-])[O-].[K+].[K+]>>CCCNC(=O)Nc1ccc(Oc2ccnc3cc(OCc4ccncc4)c(OC)cc23)cc1Cl",
        "output": "49"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.ClCCl.NCc1ccc(-c2ccc([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)cc2)cn1.O>>CC(=O)NCc1ccc(-c2ccc([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)cc2)cn1",
        "output": "339"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1c(Br)c(-c2cccnc2)n2c1CCCC2.[Na+].[OH-]>>O=C(O)c1c(Br)c(-c2cccnc2)n2c1CCCC2",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CS(=O)(=O)c1cccc(Oc2ccc([N+](=O)[O-])cc2Cl)c1.O.[Ca+2].[Cl-].[Cl-]>>CS(=O)(=O)c1cccc(Oc2ccc(N)cc2Cl)c1",
        "output": "335"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.COc1ccc(CC(=O)O)cc1OC.ClCCCl.ClCCl.O.O=S(Cl)Cl.OCc1ccccc1>>COc1ccc(CC(=O)OCc2ccccc2)cc1OC",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)c1ccc2nc3ccc(C(=O)O)cn3c(=O)c2c1.CCN(CC)CC.CN(C)C=O.NCCCCCCc1cccnc1.O.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1.[Na+].[OH-]>>CC(C)c1ccc2nc3ccc(C(=O)NCCCCCCc4cccnc4)cn3c(=O)c2c1",
        "output": "674"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CC1.NC(=O)c1ccnc(-c2c[nH]cn2)c1>>NC(=O)c1ccnc(-c2cn(CC3CC3)cn2)c1",
        "output": "276"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CCN(CC)CC.ClCCl.O.O=C(Cl)COc1cccc(Br)c1>>CC(C)(C)OC(=O)N1CCC(NC(=O)COc2cccc(Br)c2)CC1",
        "output": "45"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(C)=O.ClCCl.NNc1nncc(N2CCC(c3cccc(Cl)c3Cl)CC2)c1Cl.O.O=C(O)CC1CC1.O=C([O-])O.O=S(Cl)Cl.[Na+]>>O=C(CC1CC1)NNc1nncc(N2CCC(c3cccc(Cl)c3Cl)CC2)c1Cl",
        "output": "459"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)[C@H](CCc1ccc(O)cc1)NC(=O)OCc1ccncc1.Cl.O.[Li+].[OH-]>>O=C(N[C@@H](CCc1ccc(O)cc1)C(=O)O)OCc1ccncc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1n[nH]c(=O)c(-c2c(F)cc(F)cc2F)c1-c1ccc(C(F)(F)F)cc1.O=P(Cl)(Cl)Cl>>Cc1nnc(Cl)c(-c2c(F)cc(F)cc2F)c1-c1ccc(C(F)(F)F)cc1",
        "output": "537"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(c1ccc(NCC2CCC(F)(F)CC2)c([N+](=O)[O-])c1)S(=O)(=O)c1ccccc1.[Pd]>>CN(c1ccc(NCC2CCC(F)(F)CC2)c(N)c1)S(=O)(=O)c1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])cc2)C(=O)C1.ClCCl.O=C(O)C(F)(F)F>>O=C1CNCCN1c1ccc([N+](=O)[O-])cc1",
        "output": "634"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCC/C(=C\\C=C\\C(=O)OC)c1ccc(OC)cc1.CO.[Na+].[OH-]>>CCCC/C(=C\\C=C\\C(=O)O)c1ccc(OC)cc1",
        "output": "58"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.COC1=CCC2C(O)CCC2C1.c1ccncc1>>COC1=CCC2C(CCC2OC(C)=O)C1",
        "output": "254"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCCCCC#Cc1ccccn1.O=c1[nH]ncc2ccccc12>>O=c1c2ccccc2cnn1CCCCC#Cc1ccccn1",
        "output": "577"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(C)C[Al+]CC(C)C.CCCCCCC.CCOC(=O)C(C)Oc1ccc(Oc2ncc(Cl)cc2Cl)cc1.Cc1ccccc1.[H-]>>CC(C=O)Oc1ccc(Oc2ncc(Cl)cc2Cl)cc1",
        "output": "260"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)Cc1ncc(-c2onc([C@@H](CCCOCc3ccccc3)CC(=O)OC(C)(C)C)c2C2CC2)s1.Cc1ccccc1.O=C(O)C(F)(F)F>>CC(C)Cc1ncc(-c2onc([C@@H](CCCOCc3ccccc3)CC(=O)O)c2C2CC2)s1",
        "output": "278"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Oc1ccc(-c2cccc(C=O)c2)cc1C12CC3CC(CC(C3)C1)C2.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>O=Cc1cccc(-c2ccc(O)c(C34CC5CC(CC(C5)C3)C4)c2)c1",
        "output": "754"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NC1CCCC1.O=C(O)c1ccncc1Nc1ccc(I)cc1F>>O=C(NC1CCCC1)c1ccncc1Nc1ccc(I)cc1F",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.COC(=O)c1ccc(N)cc1.ClCCl.O=C(O)Cc1ccc2c(c1)CCC(NS(=O)(=O)c1cccs1)C2.O=S(Cl)Cl>>COC(=O)c1ccc(NC(=O)Cc2ccc3c(c2)CCC(NS(=O)(=O)c2cccs2)C3)cc1",
        "output": "710"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCOC(C)=O.COc1cccc(CO)c1.Clc1cncc(Cl)n1.O.[H-].[Na+]>>COc1cccc(COc2cncc(Cl)n2)c1",
        "output": "209"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)OC(=O)Nc1cnc2nc(-c3cc([N+](=O)[O-])ccc3F)cn2c1.[Ni]>>CC(C)OC(=O)Nc1cnc2nc(-c3cc(N)ccc3F)cn2c1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1nc(C(C)(C)N)no1.O=C(O)c1ccc(Br)c(OCC2CC2)n1>>Cc1nc(C(C)(C)NC(=O)c2ccc(Br)c(OCC3CC3)n2)no1",
        "output": "137"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.CN(C)C=O.Cc1cc(NC(=O)c2cnc(Cl)c(Cl)c2)nn1Cc1cc(Cl)ccc1OCC(C)C>>Cc1cc(NC(=O)c2cnc(N3CCOCC3)c(Cl)c2)nn1Cc1cc(Cl)ccc1OCC(C)C",
        "output": "220"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCOC(=O)[C@H](Cc1ccc(NC(=O)c2c(Cl)cncc2Cl)cc1)NC(=O)[C@@H]1C[C@@H](SC2CCCC2)CN1S(=O)(=O)c1cccc(C#N)c1.[Li+].[OH-]>>N#Cc1cccc(S(=O)(=O)N2C[C@H](SC3CCCC3)C[C@H]2C(=O)N[C@@H](Cc2ccc(NC(=O)c3c(Cl)cncc3Cl)cc2)C(=O)O)c1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.Cl.O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1>>COC(=O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.O=C(Cl)c1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-].c1ccc(C2CCCCC2)cc1>>O=C(c1ccccc1)c1ccc(C2CCCCC2)cc1",
        "output": "61"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1ccnc(-c2cc(N3CCCCC3)ccc2NC(=O)c2cccc(CSCCC(=O)OC(C)(C)C)c2)c1.O.O.[Li+].[OH-]>>CC(C)(C)OC(=O)CCSCc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)O)ccn2)c1",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)C1CC(=O)N(c2ccc(F)cc2)C1.[BH4-].[Cl-].[Li+].[Na+]>>O=C1CC(CO)CN1c1ccc(F)cc1",
        "output": "225"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.NN1CCCCC1.O=C(Cl)CCCCl.O=C([O-])O.[Na+]>>O=C(CCCCl)NN1CCCCC1",
        "output": "450"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C[Si](C)(C)I.ClCCl.O=C(N[C@H]1CCS[C@H]2CCCCN2C1=O)OCc1ccccc1>>N[C@H]1CCS[C@H]2CCCCN2C1=O",
        "output": "128"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN(C)C=O.COc1nc(CCc2ccc(O)cc2)c(C)c(OCc2ccccc2)c1OC.Cc1ccc(S(=O)(=O)OCCF)cc1.[Na+].[OH-]>>COc1nc(CCc2ccc(OCCF)cc2)c(C)c(OCc2ccccc2)c1OC",
        "output": "438"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=[N+]([O-])c1c(F)cccc1F.Oc1ccc(C(F)(F)F)cc1Cl>>O=[N+]([O-])c1c(F)cccc1Oc1ccc(C(F)(F)F)cc1Cl",
        "output": "564"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=CCBr.CN(C)C=O.O=C([O-])[O-].[K+].[K+].c1ccc2c(c1)CC[C@@H]1CNCC[C@@H]21>>CC(C)=CCN1CC[C@H]2c3ccccc3CC[C@@H]2C1",
        "output": "252"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CC[C@H](N)C(O)C(=O)NC1CC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CS(=O)(=O)c1cccc(S(=O)(=O)C[C@H](N[C@@H](c2ccc(F)cc2)C(F)(F)F)C(=O)O)c1.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>CC[C@H](NC(=O)[C@H](CS(=O)(=O)c1cccc(S(C)(=O)=O)c1)N[C@@H](c1ccc(F)cc1)C(F)(F)F)C(O)C(=O)NC1CC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(=O)CC1.COc1cc(F)ccc1N>>COc1cc(F)ccc1NC1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "469"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#Cc1ccccc1.CN(C)C[C@@H](CC(=O)OCc1ccccc1)NS(=O)(=O)c1ccc(Br)s1>>CN(C)C[C@@H](CC(=O)OCc1ccccc1)NS(=O)(=O)c1ccc(C#Cc2ccccc2)s1",
        "output": "766"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNCCN1.CC#N.Clc1nccnc1OCCOc1cccc(Br)c1.O=C([O-])[O-].[K+].[K+]>>Brc1cccc(OCCOc2nccnc2N2CCNCC2)c1",
        "output": "505"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)C1=C(Sc2ccc3c(c2)OCO3)c2ccccc2S(=O)(=O)N1Cc1ccc2c(c1)OCO2.Cl.O.[Li+].[OH-]>>O=C(O)C1=C(Sc2ccc3c(c2)OCO3)c2ccccc2S(=O)(=O)N1Cc1ccc2c(c1)OCO2",
        "output": "58"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC1CN(C(=O)OCc2ccccc2)CC(NC(=O)OC(C)(C)C)C1O.ClCCl.O=C([O-])O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+].c1ccncc1>>CC1CN(C(=O)OCc2ccccc2)CC(NC(=O)OC(C)(C)C)C1=O",
        "output": "87"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.Nc1ccc(Br)cc1.O=C(Cl)Cc1ccccc1>>O=C(Cc1ccccc1)Nc1ccc(Br)cc1",
        "output": "9"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Fc1ccc2nnc(CCN3CCCC3)n2c1.N[C@H]1CC[C@@H](O)c2ccccc21.[H-].[Na+]>>N[C@H]1CC[C@@H](Oc2ccc3nnc(CCN4CCCC4)n3c2)c2ccccc21",
        "output": "823"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCC(N2CCNCC2)C1.C1CCOC1.CCN(CC)CC.CCOC(=O)C1CCC(Nc2ccccc2F)CC1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CO.F[B-](F)(F)F.O.O.[Li]O>>O=C(C1CCC(Nc2ccccc2F)CC1)N1CCN(C2CCCC2)CC1",
        "output": "494"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.NC(=O)c1[nH]cnc1-c1ccc([N+](=O)[O-])cc1.[H][H].[Pd]>>NC(=O)c1[nH]cnc1-c1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)[O-].COc1ccc(F)c(C=O)c1.Cc1ccccc1.O=C1CSC(=S)N1.[NH4+]>>COc1ccc(F)c(C=C2SC(=S)NC2=O)c1",
        "output": "314"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(F)cc1C(=O)c1cnc(NC2CCNCC2)nc1N.O=C(O)C(F)(F)F.O=C(O)CCN1CCCCC1>>COc1ccc(F)cc1C(=O)c1cnc(NC2CCN(C(=O)CCN3CCCCC3)CC2)nc1N",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCCCCCCCCC(=O)NCCN=[N+]=[N-].CCN(CC)CC.Cc1c(C)c(C)c(S(=O)(=O)Cl)c(C)c1C.ClCCl.[N-]=[N+]=NCCN>>Cc1c(C)c(C)c(S(=O)(=O)NCCN=[N+]=[N-])c(C)c1C",
        "output": "43"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cl.Cl[Sn]Cl.O=[N+]([O-])c1c(F)cccc1OCc1ccccc1>>Nc1c(F)cccc1OCc1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(C)=O.C[C@@H]1CN([C@H](c2ccsc2)c2cccc(O)c2)[C@@H](C)CN1.O=Cc1ccc(F)cc1.OCc1ccc(F)cc1.[Na+]>>C[C@@H]1CN([C@H](c2ccsc2)c2cccc(O)c2)[C@@H](C)CN1Cc1ccc(F)cc1",
        "output": "765"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.C[C@@H](O)C(F)(F)F.Cc1cc(-c2nc(-c3cccc4c3ccn4CC(N)=O)no2)ccc1F.O.[H-].[Na+]>>Cc1cc(-c2nc(-c3cccc4c3ccn4CC(N)=O)no2)ccc1O[C@H](C)C(F)(F)F",
        "output": "485"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.CC(C)C1CCc2ncnc(N3CC4(CCN(Cc5ccccc5)CC4)c4c(CN)cccc43)c21.ClCCCl.[Na+]>>CC(C)NCc1cccc2c1C1(CCN(Cc3ccccc3)CC1)CN2c1ncnc2c1C(C(C)C)CC2",
        "output": "589"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=C(O)c1cc([N+](=O)[O-])ccc1O.O=S(=O)(O)O>>COC(=O)c1cc([N+](=O)[O-])ccc1O",
        "output": "33"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCCCCCCCCCBr.CCOC(=O)c1cc[nH]c1.CN(C)C=O.O.[H-].[Na+]>>CCCCCCCCCCCCCCn1ccc(C(=O)OCC)c1",
        "output": "470"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCC.CN(C)C=O.O.OCCCBr.SC1CCCC1.[H-].[Na+]>>OCCCSC1CCCC1",
        "output": "185"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)c1cc(C(=O)O)[nH]n1.CC(N)Cc1ccc(-c2ccc(Cl)c(Cl)c2)o1.CN(C)C=O.ClCCl.ClCCl>>CC(Cc1ccc(-c2ccc(Cl)c(Cl)c2)o1)NC(=O)c1cc(C(C)(C)C)n[nH]1",
        "output": "816"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CCCCCO.CCOCC.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CCOC(=O)CCCCC=O",
        "output": "142"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1NCC12COC2.CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc3c(c12)CCC(C(=O)O)C3.O=C(O)C(=O)O>>CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc3c(c12)CCC(C(=O)N1CC2(COC2)C1)C3",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCNC1.C=C(C)C(=O)Cl.CCN(CC)CC.CCOCC.O>>C=C(C)C(=O)N1CCCC1",
        "output": "135"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCOC(C)=O.Cn1c(=O)c2c(nc(Cl)n2-c2ccccc2Cl)n(C)c1=O>>Cn1c(=O)c2c(nc(N3CCN(C(=O)OC(C)(C)C)CC3)n2-c2ccccc2Cl)n(C)c1=O",
        "output": "36"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1nc2ccc(C(O)(c3ccc(C(F)(F)F)nc3)c3cncn3C)cc2c(Cl)c1CCC1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F.[Na+].[OH-]>>COc1nc2ccc(C(O)(c3ccc(C(F)(F)F)nc3)c3cncn3C)cc2c(Cl)c1CCC1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2C=O)c1.N[C@H]1c2ccccc2C[C@H]1O>>COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CN[C@H]2c3ccccc3C[C@H]2O)c1",
        "output": "683"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1nc(C(=O)N2[C@H]3C[C@H]3C[C@H]2CN)c(-c2cccc(F)c2)s1.O=C(O)c1cc2cc(F)ccc2[nH]1>>Cc1nc(C(=O)N2[C@H]3C[C@H]3C[C@H]2CNC(=O)c2cc3cc(F)ccc3[nH]2)c(-c2cccc(F)c2)s1",
        "output": "137"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.O=C1C(Br)=C(c2ccccc2)c2ccc(O)cc21.OCCN1CCOCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C1C(Br)=C(c2ccccc2)c2ccc(OCCN3CCOCC3)cc21",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)[C@@H](NC(=O)c1ccc(Cl)cc1N)C1CCCCC1.O=C=Nc1c(Cl)cc(Cl)cc1Cl.c1ccncc1>>COC(=O)[C@@H](NC(=O)c1ccc(Cl)cc1NC(=O)Nc1c(Cl)cc(Cl)cc1Cl)C1CCCCC1",
        "output": "993"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.COC1CCC(CO)CO1.c1ccncc1>>COC1CCC(COC(C)=O)CO1",
        "output": "254"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CCS(=O)(=O)Nc1ccc(NCC2CCC(F)(F)CC2)c([N+](=O)[O-])c1.CO.[Pd]>>CCS(=O)(=O)Nc1ccc(NCC2CCC(F)(F)CC2)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)N.CC1(C)[C@H]2CC[C@]1(C)c1c2c(C(=O)O)nn1-c1ccc(F)cc1F.CCN(CC)CC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F>>CC(C)(C)NC(=O)c1nn(-c2ccc(F)cc2F)c2c1[C@@H]1CC[C@@]2(C)C1(C)C",
        "output": "816"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CCN(c2nc3ncc(Cl)cc3n3cnnc23)C1.ClCCl.O=C(O)C(F)(F)F>>N[C@@H]1CCN(c2nc3ncc(Cl)cc3n3cnnc23)C1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNCCNc1ccnc(N)n1.Cl.Cl.Nc1nc(Cl)c2c(n1)-c1ccccc1CCC2>>CN(CCNc1ccnc(N)n1)c1nc(N)nc2c1CCCc1ccccc1-2",
        "output": "296"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CCCc1cnc(N)cn1)C(=O)O.Cl.FC(F)=C1CCNCC1>>CC(C)(C)OC(=O)N[C@@H](CCCc1cnc(N)cn1)C(=O)N1CCC(=C(F)F)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(N)C(=O)OCC(C)C.O=C(O)Cc1ccccc1O>>CCC(NC(=O)Cc1ccccc1O)C(=O)OCC(C)C",
        "output": "107"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].Cc1cc(C(=O)O)ccc1Br.Cc1cccc(B(O)O)c1.O.[Pd+2]>>Cc1cccc(-c2ccc(C(=O)O)cc2C)c1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCCCn1c2ccccc2c2ccccc21>>CS(=O)(=O)OCCCn1c2ccccc2c2ccccc21",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1c(F)ccc(N)c1F.O=C([O-])Cc1nc(N2CCOCC2)cc(=O)[nH]1.[Na+]>>COc1c(F)ccc(NC(=O)Cc2nc(N3CCOCC3)cc(=O)[nH]2)c1F",
        "output": "891"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O.COC(=O)Cc1c2n(c3ncccc13)CC(N(C)S(=O)(=O)c1ccc(F)cc1)CC2.O.O.[Cl-].[Li+].[Na+].[OH-]>>CN(C1CCc2c(CC(=O)O)c3cccnc3n2C1)S(=O)(=O)c1ccc(F)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COc1nc(C(F)(F)F)cc(CO[Si](C)(C)C(C)(C)C)c1CCN.ClCCl>>COc1nc(C(F)(F)F)cc(CO[Si](C)(C)C(C)(C)C)c1CCNC(=O)OC(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CO.COc1ccn2c(-c3ccccc3)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)nc2n1.Cl.ClCCl.[Na+].[OH-]>>COc1ccn2c(-c3ccccc3)c(-c3ccc(C4(N)CCC4)cc3)nc2n1",
        "output": "793"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.O=C(N[C@H]1CCOC1)C1CCN(c2cncnc2-c2ccc(F)cc2)CC1.[Cl-].[H-].[NH4+].[Na+].c1ccncc1>>CN(C(=O)C1CCN(c2cncnc2-c2ccc(F)cc2)CC1)[C@H]1CCOC1",
        "output": "83"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Cc1ccc(S(=O)(=O)OCCc2csc(NC(=O)OC(C)(C)C)n2)cc1.O=C(Nc1ccc(O)cc1)c1ccccc1-c1ccc(C(F)(F)F)cc1.[H-].[Na+]>>CC(C)(C)OC(=O)Nc1nc(CCOc2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cc2)cs1",
        "output": "438"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCC.CCOC(C)=O.CNCC(c1ccc(Cl)cc1)c1ccc(Cl)cc1>>CC(=O)N(C)CC(c1ccc(Cl)cc1)c1ccc(Cl)cc1",
        "output": "494"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)C(CNC(=O)OCc1ccccc1)c1ccccc1C(F)(F)F.[Pd]>>CCOC(=O)C(CN)c1ccccc1C(F)(F)F",
        "output": "574"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Nc1ccc(B(O)O)cc1.CNc1cc(Cl)nc(N)n1>>CNc1cc(-c2ccc(NC(C)=O)cc2)nc(N)n1",
        "output": "884"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C(=O)c1ccc(OCc2ccccc2)cc1)N1CCC2(CC1)C(=O)N(C)c1ccccc12.CC(C)O.O.[BH4-].[Na+]>>CC(C(O)c1ccc(OCc2ccccc2)cc1)N1CCC2(CC1)C(=O)N(C)c1ccccc12",
        "output": "24"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCCOCCOCCO.O.O=C(Cl)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1Cl.c1ccncc1>>CCOCCOCCOCCOC(=O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1Cl",
        "output": "51"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccccc4)oc4cc(F)c(F)cc4c3=O)cc2)CCC1.NC1(c2ccc(-c3c(-c4ccccc4)oc4ccc(F)cc4c3=O)cc2)CCC1>>NC1(c2ccc(-c3c(-c4ccccc4)oc4cc(F)c(F)cc4c3=O)cc2)CCC1",
        "output": "793"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=CCc1c(Cl)nc2ccnn2c1Cl.O.O=S([O-])[O-].O=[Os](=O)(=O)=O.[Na+].[Na+].[Na+].[O-][I+3]([O-])([O-])[O-]>>O=CCc1c(Cl)nc2ccnn2c1Cl",
        "output": "571"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.Cc1ccccc1.O=[N+]([O-])c1cnc2cccnc2c1NCc1cc(-c2ccc(F)cc2)no1.[Pt]>>Nc1cnc2cccnc2c1NCc1cc(-c2ccc(F)cc2)no1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1nc2n(c(=O)c1CCCl)CCCC2.Fc1ccc2c(C3CCNCC3)noc2c1.O=C([O-])[O-].[Na+].[Na+]>>Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2",
        "output": "138"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1ccc2nc(CCN)cn2c1.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(-c2cccc(F)c2)nc1>>Cc1ccc2nc(CCNC(=O)c3ccc(-c4cccc(F)c4)nc3)cn2c1",
        "output": "674"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(C)=O.CNC.COC(=O)C1CC(=O)C1.[Na+].[Na+].[OH-]>>COC(=O)C1CC(N(C)C)C1",
        "output": "187"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COC(=O)CCN.COC(=O)c1ccc(C(CC(C)C)Nc2cc(C)c(-c3ccc(C(F)(F)F)cc3)c(C)c2)nc1.Cl.Cl.F[P-](F)(F)(F)(F)F.O.[Cl-].[Li+].[NH4+].[OH-]>>COC(=O)CCNC(=O)c1ccc(C(CC(C)C)Nc2cc(C)c(-c3ccc(C(F)(F)F)cc3)c(C)c2)nc1",
        "output": "862"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)CC=O.CC(C)=CCN(c1ccc(CCc2ccccc2)cc1)C1CCNCC1>>CC(C)=CCN(c1ccc(CCc2ccccc2)cc1)C1CCN(CCC(C)(C)C)CC1",
        "output": "484"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)N1CCc2c(sc(C)c2CCCCCl)C1.Cl.Fc1ccc2c(C3CCNCC3)noc2c1>>CC(=O)N1CCc2c(sc(C)c2CCCCN2CCC(c3noc4cc(F)ccc34)CC2)C1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(NS(=O)(=O)C(F)(F)F)c1ncc(-c2ccc(N)cc2)s1.COC(=O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1.O=C=Nc1ccccc1Cl>>CC(C)(NS(=O)(=O)C(F)(F)F)c1ncc(-c2ccc(NC(=O)Nc3ccccc3Cl)cc2)s1",
        "output": "473"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1cc(S(=O)(=O)Cl)ccc1Cl.Nc1cc(Cl)cnc1Br.c1ccncc1>>CC(C)(C)c1cc(S(=O)(=O)Nc2cc(Cl)cnc2Br)ccc1Cl",
        "output": "554"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1nc2c(C)cc(C)nc2n1Cc1ccc(C(=O)O)cc1.NCCCCN1CCCCCC1>>CCc1nc2c(C)cc(C)nc2n1Cc1ccc(C(=O)NCCCCN2CCCCCC2)cc1",
        "output": "821"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(C#CC#CC(C)N2CCOCC2)cc1.O>>CC(C#CC#Cc1ccc(C(=O)O)cc1)N1CCOCC1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CNS(=O)(=O)c1ccccc1Nc1nc(Cl)ncc1Br.COc1ccc(N)c(OC)c1.Cl.O>>CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(OC)cc2OC)ncc1Br",
        "output": "907"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc(Cc2cnc(N)nc2N)c2cccnc2c1.O=S(=O)(O)O.O=[N+]([O-])O.[Na+].[OH-]>>COc1cc(Cc2cnc(N)nc2N)c2cccnc2c1[N+](=O)[O-]",
        "output": "328"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.Cl.ClCCCl.NNc1ccc(F)cn1.O=C(O)CCN1CCCC1.On1nnc2ccccc21>>O=C(CCN1CCCC1)NNc1ccc(F)cn1",
        "output": "459"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)N=C=NC(C)C.CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)c1ccncc1.Cl.NCC(N)=O.O=C(O)c1cccc(OCCCOc2ncnc3scc(-c4ccc(F)cc4)c23)c1.On1nnc2ccccc21>>NC(=O)CNC(=O)c1cccc(OCCCOc2ncnc3scc(-c4ccc(F)cc4)c23)c1",
        "output": "718"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CN(C)c1ccc(OC(F)(F)F)cc1.CO.Cl.O.[K+].[OH-]>>CN(CC(=O)O)c1ccc(OC(F)(F)F)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOc1ccc(C2(C(=O)Cl)CC2(Cl)Cl)cc1.Cc1ccccc1.Cl.O.OCc1ccc(F)c(Oc2ccccc2)c1.c1ccncc1>>CCOc1ccc(C2(C(=O)OCc3ccc(F)c(Oc4ccccc4)c3)CC2(Cl)Cl)cc1",
        "output": "126"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.CCOC(C)=O.[Pd]>>CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1nc2sccn2c1C(=O)NC[C@H]1NC[C@@H]2C[C@H]12.Nc1nc(C(=O)O)c(-c2cccc(F)c2)s1>>Cc1nc2sccn2c1C(=O)NC[C@@H]1[C@H]2C[C@H]2CN1C(=O)c1nc(N)sc1-c1cccc(F)c1",
        "output": "747"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Ic1ccccc1.OB(O)c1ccccc1.[K+].[OH-]>>c1ccc(-c2ccccc2)cc1",
        "output": "855"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COc1cc(C)cc(Br)c1.Cl.ClCCl.O=Cc1ccccc1.[Li]CCCC>>COc1cc(C)cc(C(O)c2ccccc2)c1",
        "output": "379"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.COC(=O)Cc1ccc(O)cc1.Cc1oc(-c2ccccc2)nc1COc1ccc(CCl)cc1.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)Cc1ccc(OCc2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)cc1",
        "output": "49"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc(C2=NSC(C)(c3cc(Cl)cc(Cl)c3)C2)cc1C.O.[Li+].[OH-]>>Cc1cc(C2=NSC(C)(c3cc(Cl)cc(Cl)c3)C2)ccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCC(=O)Cl.Cc1[nH]c2c(-c3cc(C(F)F)ccc3OCC3CC3)ncnc2c1C(=O)N[C@@H]1CC[C@@H](N)C[C@H]1F>>COCC(=O)N[C@@H]1CC[C@@H](NC(=O)c2c(C)[nH]c3c(-c4cc(C(F)F)ccc4OCC4CC4)ncnc23)[C@H](F)C1",
        "output": "45"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCc1ccc(Oc2ccc(C)c(O)c2)cc1C.CS(C)=O.Cl.Fc1ccc(C(F)(F)F)cc1Br.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CCc1ccc(Oc2ccc(C)c(Oc3ccc(C(F)(F)F)cc3Br)c2)cc1C",
        "output": "564"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)[C@H]1[C@@H]2CC[C@@](N)(C(=O)O)[C@H]12.Cl.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)[C@H]1[C@@H]2CC[C@@](NC(=O)OC(C)(C)C)(C(=O)O)[C@H]12",
        "output": "626"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.C1COCCO1.CN(CCOc1ncc(B2OC(C)(C)C(C)(C)O2)cc1C(F)(F)F)C(=O)OC(C)(C)C.CNc1cc(Cl)nc(C#N)c1N.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>CNc1cc(-c2cnc(OCCN(C)C(=O)OC(C)(C)C)c(C(F)(F)F)c2)nc(C#N)c1N",
        "output": "968"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCS(=O)(=O)Cl.ClCCl.NCCSc1cccc2nccn12>>CCS(=O)(=O)NCCSc1cccc2nccn12",
        "output": "493"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrBr.Cl.O=C1CCc2ccccc21.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C1CCc2ccc(Br)cc21",
        "output": "98"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN1CC[NH+](C)C1Cl.ClC(Cl)Cl.ClCCl.NCc1ccccc1.O=C(O)c1cccc(S(=O)(=O)N2CCCCC2)c1.[Cl-]>>O=C(NCc1ccccc1)c1cccc(S(=O)(=O)N2CCCCC2)c1",
        "output": "753"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)NC1CCNCC1.CCN1CCC(=O)CC1.O.[Na+]>>CCN1CCC(N2CCC(NC(=O)OC(C)(C)C)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(=O)CC1.CC(Cl)Cl.Nc1ccc(Br)cc1.[Na+]>>CC(C)(C)OC(=O)N1CCC(Nc2ccc(Br)cc2)CC1",
        "output": "469"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCOc1cc(Cc2cnc(N)nc2N)cc(OCC)c1-c1cccc(N)c1.CN(C)C=O.CS(=O)(=O)Cl>>CCOc1cc(Cc2cnc(N)nc2N)cc(OCC)c1-c1cccc(NS(C)(=O)=O)c1",
        "output": "194"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN(C)C=O.CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)O)ccc3C)cc12.Cl.NC1(c2cccnn2)CC1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5cccnn5)CC4)ccc3C)cc12",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(CBr)CC1.CN(C)C=O.NC(=O)c1n[nH]c2c1CCc1cnc(I)nc1-2.O.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)(C)OC(=O)N1CCC(Cn2nc(C(N)=O)c3c2-c2nc(I)ncc2CC3)CC1",
        "output": "577"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)Br.CC(C)c1cc2c(cc1O)C(=O)CCC2.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CC(C)Oc1cc2c(cc1C(C)C)CCCC2=O",
        "output": "153"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCN=C=NCCCN(C)C.COc1cc2c(cc1C(=O)CCC(=O)O)CCCC2.Nc1nc(-c2ccccc2)c(Cc2ccccc2)s1.O.On1nnc2ccccc21>>COc1cc2c(cc1C(=O)CCC(=O)Nc1nc(-c3ccccc3)c(Cc3ccccc3)s1)CCCC2",
        "output": "681"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CCO.Cc1c(OCc2ccccc2)cc(C#N)cc1[N+](=O)[O-].[Fe]>>Cc1c(N)cc(C#N)cc1OCc1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)N.CCCCc1oc2ccccc2c1S(=O)(=O)c1ccc(OCC2CO2)cc1.ClC(Cl)Cl>>CCCCc1oc2ccccc2c1S(=O)(=O)c1ccc(OCC(O)CNC(C)C)cc1",
        "output": "16"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)Oc1cc(F)ccc1[N+](=O)[O-].CN1CCNCC1.CS(C)=O.O.O=C([O-])[O-].[K+].[K+]>>CC(C)Oc1cc(N2CCN(C)CC2)ccc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCO.N#Cc1cc(-c2ccc(Cl)cc2)c(-c2ccccc2Cl)nc1OCc1ccc(F)c(F)c1.O.O=C(O)C(F)(F)F.OO.[K+].[OH-]>>NC(=O)c1cc(-c2ccc(Cl)cc2)c(-c2ccccc2Cl)nc1OCc1ccc(F)c(F)c1",
        "output": "677"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.C1CCOC1.CCN(CC)CC.CCOC(C)=O.CN(C)c1ccncc1.Nc1ncc(Br)s1.O=C(Cl)C12CC3CC(CC(C3)C1)C2>>O=C(Nc1ncc(Br)s1)C12CC3CC(CC(C3)C1)C2",
        "output": "553"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.COc1ccc(-c2ccn3c(-c4ccc(CNC(=O)Nc5cc(C(C)(C)C)on5)cc4)cnc3c2)cn1>>CC(C)(C)c1cc(NC(=O)NCc2ccc(-c3cnc4cc(-c5ccc(=O)[nH]c5)ccn34)cc2)no1",
        "output": "758"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.ClCCl.Fc1cc(C(F)(F)F)ccc1/C=C/c1nc(COc2ccc(CSCCn3ccnn3)cc2)co1.O=C(OO)c1cccc(Cl)c1>>O=S(CCn1ccnn1)Cc1ccc(OCc2coc(/C=C/c3ccc(C(F)(F)F)cc3F)n2)cc1",
        "output": "13"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCN(CCC2CCNCC2)C1.COc1cc(C)c(S(=O)(=O)N2CCCC2COCC(=O)O)c(C)c1.ClCCl.O=C([O-])O.[Na+]>>COc1cc(C)c(S(=O)(=O)N2CCCC2COCC(=O)N2CCC(CCN3CCCC3)CC2)c(C)c1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=C(C)C(=O)OCCN=C=O.C=C(C)C(=O)OCCNC(=O)Nc1ccc(-c2ccc(NC(=O)NCCOC(=O)C(=C)C)c([N+](=O)[O-])c2)cc1[N+](=O)[O-].CC(=O)N(C)C.CC(=O)O.CCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCC(=O)[O-].CCCC[Sn+2]CCCC.N.Nc1ccc(-c2ccc(N)c([N+](=O)[O-])c2)cc1[N+](=O)[O-].O>>C=C(C)C(=O)OCCNC(=O)Nc1ccc(-c2ccc(NC(=O)NCCOC(=O)C(=C)C)c(N)c2)cc1N",
        "output": "204"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1[nH]c(C)c(-c2ccc(C(=O)O)cc2)c1C.CCOC(C)=O.CN(C)C=O.ClCCl.Nc1ccc(N2CCOCC2)cc1.O=C(Cl)C(=O)Cl.O=C([O-])O.[Na+]>>CCOC(=O)c1[nH]c(C)c(-c2ccc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc2)c1C",
        "output": "50"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CC(C2CNC2)CCO1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1.COC(OC)OC.ClCCCl.[Na+]>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CC(C4CCOCC4)C3)n(C)c2n1",
        "output": "944"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.C1CCOC1.COC(=O)Cl.C[C@H](N)CNc1nccc(-c2[nH]c(C3(C)CC3)nc2Br)n1.O.O=C([O-])O.[Na+]>>COC(=O)N[C@@H](C)CNc1nccc(-c2[nH]c(C3(C)CC3)nc2Br)n1",
        "output": "94"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCCSSCCN.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cnc(C(=O)O)c[n+]1[O-].F[P-](F)(F)(F)(F)F>>Cc1cnc(C(=O)NCCSSCCNC(=O)OC(C)(C)C)c[n+]1[O-]",
        "output": "697"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1c(S(=O)(=O)N[C@H](C)C(F)(F)F)cn(C)c1C(=O)O.Nc1cc(F)c(F)c(Cl)c1>>Cc1c(S(=O)(=O)N[C@H](C)C(F)(F)F)cn(C)c1C(=O)Nc1cc(F)c(F)c(Cl)c1",
        "output": "548"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC.CI.CN(C)C=O.O.O=C([O-])[O-].Oc1ccc(OC(F)(F)F)cc1Br.[K+].[K+]>>COc1ccc(OC(F)(F)F)cc1Br",
        "output": "62"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(CC)c1ccc(OC)c2nc(Cl)n(C)c12.CN1CCCC1=O.COc1cc(Cl)cc(C)c1N.O>>CCC(CC)c1ccc(OC)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12",
        "output": "808"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc(-n2cccn2)cc1.ClCCl>>Oc1ccc(-n2cccn2)cc1",
        "output": "402"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOP(=O)(C#N)OCC.CNOC.Cl.N#Cc1cc(C(=O)O)cc(C(F)(F)F)c1>>CON(C)C(=O)c1cc(C#N)cc(C(F)(F)F)c1",
        "output": "828"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.COc1ccc(CCCC(=O)O)cc1.ClCCl.O=C([O-])O.[Na+]>>O=C(O)CCCc1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(-c2ccc(C(F)(F)F)cc2)cc1C(=O)O.Cc1noc([C@H](N)Cc2cccc(-c3ccc(F)c(Cl)c3)c2)n1.Cl>>COc1ccc(-c2ccc(C(F)(F)F)cc2)cc1C(=O)N[C@H](Cc1cccc(-c2ccc(F)c(Cl)c2)c1)c1nc(C)no1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(CO)n1cc(Br)cn1.ClCCN1CCCC1.[H-].[Na+]>>CC(C)(COCCN1CCCC1)n1cc(Br)cn1",
        "output": "308"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ncc(-c2cc3cncc(-c4cc(C)c(OC)c(C)c4)c3o2)cc1N.CS(=O)(=O)Cl>>COc1ncc(-c2cc3cncc(-c4cc(C)c(OC)c(C)c4)c3o2)cc1NS(C)(=O)=O",
        "output": "812"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1ccccc1.Nc1ncc(Cl)nc1C(=O)O>>Nc1ncc(Cl)nc1C(=O)Nc1ccccc1",
        "output": "889"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCSc1c([N+](=O)[O-])cc(C(=O)O)cc1S(N)(=O)=O.Cc1ccccc1Sc1c([N+](=O)[O-])cc(C(=O)O)cc1S(N)(=O)=O>>Cc1ccccc1Sc1c(N)cc(C(=O)O)cc1S(N)(=O)=O",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1ccc(-c2cccc(C(CC(=O)c3ccnc(C)c3)c3ccccc3C)c2)cc1F.Cl.NO.O=C([O-])O.[Na+]>>COC(=O)c1ccc(-c2cccc(C(CC(=NO)c3ccnc(C)c3)c3ccccc3C)c2)cc1F",
        "output": "212"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)Cl.Cc1c2c(nc3c(C(F)(F)F)cccc13)CCNCC2>>CCOC(=O)N1CCc2nc3c(C(F)(F)F)cccc3c(C)c2CC1",
        "output": "219"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C(OC(C)(C)C)OC(C)(C)C.Cc1ccccc1.O=C(O)c1cc2c(Br)cccc2[nH]1>>CC(C)(C)OC(=O)c1cc2c(Br)cccc2[nH]1",
        "output": "768"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.COC(=O)c1cccc(NC(=O)c2ccc(C#N)cc2)c1.NN.O>>N#Cc1ccc(C(=O)Nc2cccc(C(=O)NN)c2)cc1",
        "output": "421"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)C(Cc1cc(OCC)c(O)cc1F)OCC.CCOC(=O)N=NC(=O)OCC.COC(=O)CC(=O)C(C)Br.Cc1sc(-c2ccc(Cl)cc2)nc1CCO.NC(=S)c1ccc(Cl)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)C(Cc1cc(OCC)c(OCCc2nc(-c3ccc(Cl)cc3)sc2C)cc1F)OCC",
        "output": "478"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC=C(c2ccc3nc(OC4CCN(C(=O)OCC[Si](C)(C)C)CC4)sc3c2)CC1.CCOC(C)=O.[Pd]>>CC(C)(C)OC(=O)N1CCC(c2ccc3nc(OC4CCN(C(=O)OCC[Si](C)(C)C)CC4)sc3c2)CC1",
        "output": "806"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.N#Cc1c(NCc2ccccc2)cccc1-c1ccccc1.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>NCc1c(NCc2ccccc2)cccc1-c1ccccc1",
        "output": "175"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.Clc1ccc(Cl)nc1.[C-]#N.[C-]#N.[Zn+2].[Zn]>>N#Cc1ccc(Cl)cn1",
        "output": "726"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccc(Br)cc1.CCOC(C)=O.CS(C)=O.[N-]=[N+]=[N-].[Na+]>>[N-]=[N+]=NCc1ccc(Br)cc1",
        "output": "643"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)C(C)(C)Cc1[nH]c2cc(OCc3ccc4ccccc4n3)ccc2c1Cc1ccc(Cl)cc1.COC(=O)C(C)(C)Cc1c(SC(C)(C)C)c2cc(OC)ccc2n1Cc1ccc(Cl)cc1.O.[Na]>>CC(C)(Cc1[nH]c2cc(OCc3ccc4ccccc4n3)ccc2c1Cc1ccc(Cl)cc1)C(=O)O",
        "output": "361"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COS(=O)(=O)OC.Cc1cc(O)cc(O)c1.[Na+].[OH-]>>COc1cc(C)cc(O)c1",
        "output": "317"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCN(CC)CC.NC[C@@H]1C[C@@H](n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc32)C1.O=C(Cl)CCl>>Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2[C@@H]1C[C@@H](CNC(=O)CCl)C1",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.N#Cc1cccc(C(F)(F)c2cc(OCC(F)F)cc([N+](=O)[O-])c2)c1.O.[Cl-].[NH4+].[Zn]>>N#Cc1cccc(C(F)(F)c2cc(N)cc(OCC(F)F)c2)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.Cc1c(N[C@@H]2CCOC2)nc(-c2cccc(O)c2)nc1N1CCOCC1.ClCC1CO1.O=C([O-])[O-].[K+].[K+]>>Cc1c(N[C@@H]2CCOC2)nc(-c2cccc(OCC3CO3)c2)nc1N1CCOCC1",
        "output": "15"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.COC(=O)c1ccc(C)c(C(=O)c2ccc(N)cc2Cl)c1.Fc1cc(Cl)ccc1Br.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2]>>COC(=O)c1ccc(C)c(C(=O)c2ccc(Nc3ccc(Cl)cc3F)cc2Cl)c1",
        "output": "405"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)c1ccc2c(c1)CC(C)(C)C(c1ccc(N3CCOCC3)cc1)N2.CO.Cl.O.O.[Li+].[OH-]>>CC1(C)Cc2cc(C(=O)O)ccc2NC1c1ccc(N2CCOCC2)cc1",
        "output": "5"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)CC(=O)Cl.CCOC(C)=O.CSc1nccc(-c2c(-c3cccc(C)n3)nc3nc(N)ccn23)n1.O.c1ccncc1>>CSc1nccc(-c2c(-c3cccc(C)n3)nc3nc(NC(=O)CC(C)(C)C)ccn23)n1",
        "output": "332"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1cc(OCC(N)=O)cc(C(=O)OC)c1.[Na+].[OH-]>>COC(=O)c1cc(OCC(N)=O)cc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CNC.CO.O=S(=O)(Cl)c1cnc(Cl)c(Br)c1>>CN(C)S(=O)(=O)c1cnc(Cl)c(Br)c1",
        "output": "169"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CI.C[Si](C)(C)[N-][Si](C)(C)C.Cn1ncc([N+](=O)[O-])c1N1CCC(NC(=O)OC(C)(C)C)CC(F)(F)C1.O.[Li+]>>CN(C(=O)OC(C)(C)C)C1CCN(c2c([N+](=O)[O-])cnn2C)CC(F)(F)C1",
        "output": "803"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC1(C(=O)Nc2cc(OC(C)C)n(COCC[Si](C)(C)C)n2)CCCN(S(=O)(=O)c2cn(C)cn2)C1.O=C(O)C(F)(F)F>>CCC1(C(=O)Nc2cc(OC(C)C)[nH]n2)CCCN(S(=O)(=O)c2cn(C)cn2)C1",
        "output": "813"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COCC1CCCN1c1cnn2c1CNCC2.Fc1ccc(-c2cnn3c2CNCC3)cc1.O=C(Nc1ccc(F)c(Cl)c1)Oc1ccccc1.O=C(Nc1ccc(F)c(Cl)n1)N1CCn2ncc(-c3ccc(F)cc3)c2C1>>COCC1CCCN1c1cnn2c1CN(C(=O)Nc1ccc(F)c(Cl)c1)CC2",
        "output": "525"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1nn(-c2ccc(OC)cc2)c2c1CCN(c1ccc(-n3ccccc3=O)cc1)C2=O.CO.Cl.O.[Li+].[OH-]>>COc1ccc(-n2nc(C(=O)O)c3c2C(=O)N(c2ccc(-n4ccccc4=O)cc2)CC3)cc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CCOC(C)=O.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(B3OC(C)(C)C(C)(C)O3)cc12.Clc1ccc2c(n1)-c1c(Cl)c3ccccc3n1CO2.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc4c(n3)-c3c(Cl)c5ccccc5n3CO4)cc12",
        "output": "955"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.FC(F)(F)c1ccc(Cl)nc1.NN>>NNc1ccc(C(F)(F)F)cn1",
        "output": "417"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CC2CNCC12.CN1CCCC1=O.O.O=C(Nc1ccc(Cl)nc1)c1cc2cc(F)ccc2n1Cc1cccc(F)c1.[K+].[OH-]>>O=C(Nc1ccc(N2CC3CCC3C2)nc1)c1cc2cc(F)ccc2n1Cc1cccc(F)c1",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOc1cc(C(=O)OC)nc2c(C3CC3)cccc12.CO.Cl.ClC(Cl)Cl>>CCOc1cc(C(=O)O)nc2c(C3CC3)cccc12",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(C#N)nc1.CO.O.O=S(=O)([O-])O.[K+].[Pd]>>CC(C)(C)OC(=O)NCc1ccc(CN)nc1",
        "output": "205"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)CCN.O=C(O)[C@@H]1CCCN(S(=O)(=O)c2ccccc2Cl)C1>>CC(C)CCNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccccc2Cl)C1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1c(C#N)ccnc1F.CS(C)=O.C[C@@H]1CC[C@@H](O)CN1C(=O)OC(C)(C)C.[H-].[Na+]>>COc1c(C#N)ccnc1O[C@@H]1CC[C@@H](C)N(C(=O)OC(C)(C)C)C1",
        "output": "541"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.Cl.ClCCl.Nc1cc(C(F)(F)F)ccc1N1CCOCC1.O.O=C(Cl)c1ccncc1>>O=C(Nc1cc(C(F)(F)F)ccc1N1CCOCC1)c1ccncc1",
        "output": "11"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)CCC(NC(=O)Nc1ccc2c(c1)CCC2)c1ccc(C(=O)OCc2ccccc2)cc1.CO.[Pd]>>CN(C)CCC(NC(=O)Nc1ccc2c(c1)CCC2)c1ccc(C(=O)O)cc1",
        "output": "290"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(O)c1ccc(-c2nn(-c3ccc(C(=O)O)cc3)c3ccccc23)cc1.O=S(=O)(O)O.O=[N+]([O-])O.[Na+].[OH-]>>O=C(O)c1ccc(-c2nn(-c3ccc(C(=O)O)cc3)c3ccc([N+](=O)[O-])cc23)cc1",
        "output": "21"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCl.O=C(Cl)CCl.[Al+3].[Cl-].[Cl-].[Cl-].c1ccc2c(c1)CCCO2>>O=C(CCl)c1ccc2c(c1)CCCO2",
        "output": "31"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1ccc(C(Nc2nc3ccc(F)cc3cc2C)C2CC(C)(C)C2)cc1.Cc1cc2ccccc2nc1NC(c1ccc(C(=O)O)cc1)C1CC(C)(C)C1>>Cc1cc2cc(F)ccc2nc1NC(c1ccc(C(=O)O)cc1)C1CC(C)(C)C1",
        "output": "5"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(NC(=O)C(C)(C)NC(=O)c2ccc3c(C4CCCCC4)c4n(c3c2)CCOc2cc(OC)ccc2-4)cc1.Cl.[Na+].[OH-]>>COc1ccc2c(c1)OCCn1c-2c(C2CCCCC2)c2ccc(C(=O)NC(C)(C)C(=O)Nc3ccc(C(=O)O)cc3)cc21",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COCCOc1ccc([N+](=O)[O-])cn1.[Pd]>>COCCOc1ccc(N)cn1",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)c1ccc(OCc2conc2-c2ccc(F)cc2)nc1.NCC(O)C(F)(F)F>>O=C(NCC(O)C(F)(F)F)c1ccc(OCc2conc2-c2ccc(F)cc2)nc1",
        "output": "862"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(=O)CC1.O=C(C1CNCCN1C(=O)OCc1ccccc1)N1CCOCC1.[Na+]>>CC(C)(C)OC(=O)N1CCC(N2CCN(C(=O)OCc3ccccc3)C(C(=O)N3CCOCC3)C2)CC1",
        "output": "187"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C[C@H]1CN(c2nc3ccccc3s2)C[C@@H](C)N1.O=C(NCC(F)(F)F)C1(CCCCBr)c2ccccc2-c2ccccc21>>C[C@H]1CN(c2nc3ccccc3s2)C[C@@H](C)N1CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)CC1.CC(C)(C)[O-].Cc1c(Cl)ncnc1Cl.[K+]>>Cc1c(Cl)ncnc1OC1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "653"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.CC(=O)O.COc1cc(CCNC(=O)C(=COC(F)F)c2ccc3c(c2)CCCC3)ccc1OCc1ccccc1.O>>COc1cc(CCNC(=O)C(=COC(F)F)c2ccc3c(c2)CCCC3)ccc1O",
        "output": "23"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCC(=O)N[C@@H](C)C(=O)Oc1ccc(-c2sc3cc(O[Si](C)(C)C(C)(C)C)ccc3c2C(=O)c2ccc(OCCN3CCOCC3)cc2)cc1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCC(=O)N[C@@H](C)C(=O)Oc1ccc(-c2sc3cc(O)ccc3c2C(=O)c2ccc(OCCN3CCOCC3)cc2)cc1",
        "output": "754"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.COCCN1CCNCC1.Nc1cc(Cl)ccc1[N+](=O)[O-].O.O=C([O-])[O-].[K+].[K+]>>COCCN1CCN(c2ccc([N+](=O)[O-])c(N)c2)CC1",
        "output": "105"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)CCON=O.CCO.COc1ccc(-c2nc(Sc3ccc(C(F)(F)F)cc3N)[nH]c2-c2ccc(OC)cc2)cc1.Cl.Cl>>COc1ccc(-c2nc(Sc3ccc(C(F)(F)F)cc3)[nH]c2-c2ccc(OC)cc2)cc1",
        "output": "324"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#Cc1cccc(S(=O)(=O)CCC)c1.CC(C)(C)OC(=O)COc1ccc(F)cc1Br.CCCS(=O)(=O)c1ccc(F)c(C#Cc2cc(Cl)ccc2OCC(=O)OC(C)(C)C)c1>>CCCS(=O)(=O)c1cccc(C#Cc2cc(F)ccc2OCC(=O)OC(C)(C)C)c1",
        "output": "659"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(CC(=O)O)c(C(=O)c2cccc(F)c2)c1.COc1ccc(CC(=O)O)c(C(=O)c2ccccc2)c1>>COc1ccc(CC(=O)O)c(Cc2cccc(F)c2)c1",
        "output": "181"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1c(F)cc(Br)cc1C=O.N#Cc1ccc(B(O)O)cc1>>COc1c(F)cc(-c2ccc(C#N)cc2)cc1C=O",
        "output": "837"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO[C@@H](Cc1ccc(O)cc1C)C(=O)OC.Cc1oc(-c2ccccc2)nc1CCl.O=C([O-])[O-].[Cs+].[Cs+].[I-].[K+]>>CCO[C@@H](Cc1ccc(OCc2nc(-c3ccccc3)oc2C)cc1C)C(=O)OC",
        "output": "760"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCO.NCCCO.O=[N+]([O-])c1cc(C(F)(F)F)ccc1Cl>>O=[N+]([O-])c1cc(C(F)(F)F)ccc1NCCCO",
        "output": "304"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.Cl.O=CCC(CC(=O)n1ccc2ccccc21)c1ccc(Cl)c(Cl)c1.OC1(c2ccccc2)CCNCC1.[BH3-]C#N.[Na+]>>O=C(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)n1ccc2ccccc21",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrP(Br)Br.ClCCl.OCc1c(F)cc(Br)cc1F>>Fc1cc(Br)cc(F)c1CBr",
        "output": "300"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C1CCOC1.CC(C#N)c1nc(CO[Si](C)(C)C(C)(C)C)n(C)c1Sc1cccc(Cl)c1.CCCC[N+](CCCC)(CCCC)CCCC.O.[F-]>>CC(C#N)c1nc(CO)n(C)c1Sc1cccc(Cl)c1",
        "output": "708"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)Cl.O=C1OCCN1c1cccc(CCO)c1>>CS(=O)(=O)OCCc1cccc(N2CCOC2=O)c1",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Fc1cc(C(F)(F)F)cnc1F.OCCO>>OCCOc1ncc(C(F)(F)F)cc1F",
        "output": "541"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)CC(C)C.CNCCCCCO.Clc1nc2ccccc2s1.O=C([O-])[O-].[I-].[Na+].[Na+]>>CN(CCCCCO)c1nc2ccccc2s1",
        "output": "558"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.Cc1cc(C(=O)O)ccc1Br.[C-]#N.[C-]#N.[Pd].[Zn+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(C(=O)O)ccc1C#N",
        "output": "65"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCn1cc(C(=O)OCC)nc1Cc1ccc(Br)cc1.Cc1ccccc1.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccccc1-c1nnnn1C(c1ccccc1)(c1ccccc1)c1ccccc1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCCn1cc(C(=O)OCC)nc1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BC#N.C1CCOC1.CC(C)(C)CNc1noc2ccc(-c3cccc(C=O)c3)cc12.NC1CC1.O=C([O-])O.[H-].[Na+].[Na+]>>CC(C)(C)CNc1noc2ccc(-c3cccc(CNC4CC4)c3)cc12",
        "output": "468"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCS(=O)(=O)c1ccc(Cn2c(C)c(CC(=O)OC)c3cccnc32)c(C(F)(F)F)c1.CO.[Na+].[OH-]>>CCS(=O)(=O)c1ccc(Cn2c(C)c(CC(=O)O)c3cccnc32)c(C(F)(F)F)c1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCCN.CCN(CC)CC.O=[N+]([O-])c1cc(S(=O)(=O)Cl)sc1Cl>>CC(C)(C)OC(=O)NCCNS(=O)(=O)c1cc([N+](=O)[O-])c(Cl)s1",
        "output": "600"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)CS(=O)(=O)c1ccc2c(-c3ccccc3F)noc2c1Cl.CO.[Na+].[OH-]>>O=C(O)CS(=O)(=O)c1ccc2c(-c3ccccc3F)noc2c1Cl",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.COCOc1c(C)cc(-c2nc3cc(OCCOCc4cccnc4)cc(OC)c3c(=O)[nH]2)cc1C.O.O=S(=O)(O)O>>COc1cc(OCCOCc2cccnc2)cc2nc(-c3cc(C)c(O)c(C)c3)[nH]c(=O)c12",
        "output": "755"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.CCOC(=O)c1cccc(C2=C(c3cc(C)ccc3O)CCC2)n1.CCOCC.Fc1ccc(CBr)cc1.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cccc(C2=C(c3cc(C)ccc3OCc3ccc(F)cc3)CCC2)n1",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "N#Cc1cc(N)ccc1N1CCC(N2CCOCC2)CC1.O=C(O)c1sc2ccccc2c1Cl>>N#Cc1cc(NC(=O)c2sc3ccccc3c2Cl)ccc1N1CCC(N2CCOCC2)CC1",
        "output": "822"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COc1ccc2cc(C(=O)C(C)OS(C)(=O)=O)ccc2c1.[BH4-].[Na+]>>COc1ccc2cc(C(O)C(C)OS(C)(=O)=O)ccc2c1",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)n1cc(Cn2ccc3c([N+](=O)[O-])cccc32)c2cccnc21.[Pd]>>CC(C)(C)OC(=O)n1cc(Cn2ccc3c(N)cccc32)c2cccnc21",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cccc(C=O)c4)cc23)CC1.C[C@H](O)CN.[Na+]>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cccc(CNC[C@H](C)O)c4)cc23)CC1",
        "output": "468"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O=CCCNC(=O)c1cc([N+](=O)[O-])c(Sc2c(Cl)cncc2Cl)s1.OCC1CCNCC1>>O=C(NCCCN1CCC(CO)CC1)c1cc([N+](=O)[O-])c(Sc2c(Cl)cncc2Cl)s1",
        "output": "484"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCO.O.O=[N+]([O-])c1cc(Br)cc2cccnc12.[Fe].[Na+].[OH-]>>Nc1cc(Br)cc2cccnc12",
        "output": "269"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccc(-c2ccc3ccccc3c2)c2ccccc12.CC(C)OB(OC(C)C)OC(C)C.CCCCCC.CCOCC.Cc1ccccc1.Cl.[Li]CCCC>>OB(O)c1ccc(-c2ccc3ccccc3c2)c2ccccc12",
        "output": "832"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.O=c1onc(-c2nonc2NCCO)n1-c1cccc(C(F)(F)F)c1>>CS(=O)(=O)OCCNc1nonc1-c1noc(=O)n1-c1cccc(C(F)(F)F)c1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(c1ccccc1)N1CCC(CO)CC1>>O=CC1CCN(C(=O)c2ccccc2)CC1",
        "output": "142"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)c1ccc(N)cc1.COc1cn(C(CC2CCOC2)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1C#N>>COc1cn(C(CC2CCOC2)C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N",
        "output": "710"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.Cc1c(N)cccc1[N+](=O)[O-].O.O=C(Cl)OCCCl.O=C([O-])[O-].O=C=O.[Ca+2]>>Cc1c(NC(=O)OCCCl)cccc1[N+](=O)[O-]",
        "output": "102"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cc(C)cc(CCCO)c1.ClCCl.O=C1CCC(=O)N1Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(C)cc(CCCBr)c1",
        "output": "581"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1cccc(F)c1.O=C(O)c1ccccc1>>Nc1ccc(C(=O)c2ccccc2)c(F)c1",
        "output": "275"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(C)C=O.CNC.COc1cc(Nc2c(C#N)cnc3c(-c4ccc(C=O)cc4)csc23)c(Cl)cc1Cl.ClCCl.[Na+]>>COc1cc(Nc2c(C#N)cnc3c(-c4ccc(CN(C)C)cc4)csc23)c(Cl)cc1Cl",
        "output": "567"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCc1cc(S(=O)(=O)C(F)(F)F)ccc1N.Cc1c(Cl)cc(C(C)(C)C)c(O)c1C(=O)O>>CCc1cc(S(=O)(=O)C(F)(F)F)ccc1NC(=O)c1c(C)c(Cl)cc(C(C)(C)C)c1O",
        "output": "50"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN.CN1CCCC1=O.Nc1cc([N+](=O)[O-])ccc1F.O.O=C([O-])[O-].[K+].[K+]>>CNc1ccc([N+](=O)[O-])cc1N",
        "output": "572"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCCCC1.CCOCC.N#CC1(O)C2CC3CC(C2)CC1C3.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCC1(O)C2CC3CC(C2)CC1C3",
        "output": "246"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.Clc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.OB(O)c1ccccc1.[Pd].[Pd]>>c1ccc(-c2ccccc2)cc1",
        "output": "892"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC1CCCC1N.CCN(CC)CC.CCOC(C)=O.Cl.O=C(Cl)c1ccc(F)c(F)c1>>CC1CCCC1NC(=O)c1ccc(F)c(F)c1",
        "output": "271"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.COC(=O)c1c(CSC)[n+]([O-])c2ccccc2[n+]1[O-].ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>COC(=O)c1c(CS(C)=O)[n+]([O-])c2ccccc2[n+]1[O-]",
        "output": "13"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.CN(C)c1nc2ccccc2nc1/C=C/c1nc(Cl)cc(N2CCCC2)n1.CNC1CCOCC1.[Na+].[Pd+2]>>CN(C)c1nc2ccccc2nc1/C=C/c1nc(N2CCCC2)cc(N(C)C2CCOCC2)n1",
        "output": "162"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Clc1nc(Cl)c2c3c(sc2n1)CCCC3.NCCc1ccc2c(c1)OCO2>>Clc1nc(NCCc2ccc3c(c2)OCO3)c2c3c(sc2n1)CCCC3",
        "output": "723"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.CON=CC(CC(C)O)Sc1ccccn1.CS(=O)(=O)Cl.O>>CON=CC(CC(C)OS(C)(=O)=O)Sc1ccccn1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[O-].CCCCc1nc(Cl)c(CO)n1Cc1ccc(OCc2ccccc2C#N)cc1.CI.CS(C)=O.O.[K+]>>CCCCc1nc(Cl)c(COC)n1Cc1ccc(OCc2ccccc2C#N)cc1",
        "output": "140"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CCNC(=O)c1ccc(-c2cc(F)c(F)cc2CBr)cn1.CN(C)C=O.Nc1ccc(I)c(Cl)c1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CCNC(=O)c1ccc(-c2cc(F)c(F)cc2CNc2ccc(I)c(Cl)c2)cn1",
        "output": "272"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)COc1ccccc1S(=O)(=O)Cl.CNC.Cl.c1ccncc1>>CCOC(=O)COc1ccccc1S(=O)(=O)N(C)C",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCCC(CCBr)C1.CN(C)C=O.OCc1cc(Br)ccc1F.[H-].[I-].[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCCC(CCOCc2cc(Br)ccc2F)C1",
        "output": "95"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCNCC2)c1.Cc1ccc(C(=O)CCCCl)cc1.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(C(=O)CCCN2CCC(c3cccc(NC(=O)C(C)C)c3)CC2)cc1",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(C)=O.ClCc1cccc(OCc2ccc3ccccc3n2)c1.N#Cc1nc2ccc(O)cc2o1.[Na+].[OH-]>>N#Cc1nc2ccc(OCc3cccc(OCc4ccc5ccccc5n4)c3)cc2o1",
        "output": "49"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)OB(c2ccc(C(=O)O)c(F)c2)OC1(C)C.CCCc1ccnc(N)c1>>CCCc1ccnc(NC(=O)c2ccc(B3OC(C)(C)C(C)(C)O3)cc2F)c1",
        "output": "744"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCN=C=NCCCN(C)C.Cl.NC(Cc1ccc(F)cc1)C(O)c1ccc(C(F)(F)F)cc1.O.O=C(O)CCCc1ccccc1.On1nnc2ccccc21>>O=C(CCCc1ccccc1)NC(Cc1ccc(F)cc1)C(O)c1ccc(C(F)(F)F)cc1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O[C@H](C)CCCCn1c(=O)c2c(=O)cc(C)n(Cc3ccccc3)c2n(C)c1=O.CO.Cl>>Cc1cc(=O)c2c(=O)n(CCCC[C@@H](C)O)c(=O)n(C)c2n1Cc1ccccc1",
        "output": "325"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CN2CCC(CC2)N1.O=C(Cl)Oc1ccccc1-c1ccccc1>>O=C(Oc1ccccc1-c1ccccc1)N1CCN2CCC1CC2",
        "output": "219"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClC(Cl)Cl.O=C([O-])O.O=S(Cl)Cl.OCc1ccncc1Cl.[Na+]>>ClCc1ccncc1Cl",
        "output": "81"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCOC(=O)CCn1cnc2c(=O)[nH]cnc21.NCCc1ccc(S(N)(=O)=O)cc1>>NS(=O)(=O)c1ccc(CCNC(=O)CCn2cnc3c(=O)[nH]cnc32)cc1",
        "output": "64"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)C(=O)Cl.CCC1(CC)NC(C)(CO)COC1=O.CCN(CC)CC.CN(C)c1ccncc1.ClCCl>>CCC1(CC)NC(C)(COC(=O)C(C)(C)C)COC1=O",
        "output": "126"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(O)c1cc2ncc(Cl)cn2n1.c1ccc(-c2nnc3n2CCNC3)nc1>>O=C(c1cc2ncc(Cl)cn2n1)N1CCn2c(nnc2-c2ccccn2)C1",
        "output": "663"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "N[C@H]1CCCc2ccccc21.O=Cc1cccc(Cl)c1Cl>>Clc1cccc(CN[C@H]2CCCc3ccccc32)c1Cl",
        "output": "683"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCN1.C1COCCO1.CCN(CC)CC.CCOC(C)=O.C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1nc(Cl)ccc1Br>>C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1nc(N2CCOCC2)ccc1Br",
        "output": "220"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1CCCN(C(=O)/C=C/c2ccc(Sc3ccccc3C(C)C)c([N+](=O)[O-])c2)C1.[K+].[Na+].[OH-].[OH-]>>CC(C)c1ccccc1Sc1ccc(/C=C/C(=O)N2CCCC(C(=O)O)C2)cc1[N+](=O)[O-]",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(N=C=O)c1ccccc1.CCCCCC.CCOC(C)=O.Clc1ccc2c(N3CCNCC3)ccnc2c1>>CC(NC(=O)N1CCN(c2ccnc3cc(Cl)ccc23)CC1)c1ccccc1",
        "output": "583"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(CCS(=O)(=O)C2CCN(C(=O)OCc3ccccc3)CC2)CC1.Cl>>O=C(OCc1ccccc1)N1CCC(S(=O)(=O)CCC2CCNCC2)CC1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCOC(C)=O.Cc1cc(Nc2nc(S(=O)c3ccc(F)cc3)cc3ccccc23)nn1C(=O)OC(C)(C)C.Cl>>Cc1cc(Nc2nc(S(=O)c3ccc(F)cc3)cc3ccccc23)n[nH]1",
        "output": "896"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.Cl.Nc1cccc(OCC(=O)O)c1.O.O=N[O-].[N-]=[N+]=[N-].[Na+].[Na+]>>[N-]=[N+]=Nc1cccc(OCC(=O)O)c1",
        "output": "189"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.CC(=O)O.O.O=C(O)c1cccc2c1OCC2.[Fe]>>O=C(O)c1cc(Br)cc2c1OCC2",
        "output": "98"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN.CN(C)C=O.N#Cc1ccc(Cl)nc1>>CNc1ccc(C#N)cn1",
        "output": "70"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cl.Nc1ccc(Cl)c(C(=O)O)c1>>COC(=O)c1cc(N)ccc1Cl",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCNCC.CCOC(=O)Cl.ClC(Cl)Cl.O=C(O)c1cc2ccc(Cl)cc2c(-c2ccccc2Cl)n1>>CCN(CC)C(=O)c1cc2ccc(Cl)cc2c(-c2ccccc2Cl)n1",
        "output": "605"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCCC.CCOCC.COC(=O)C1CCN(C(=O)OC(C)(C)C)CC1.Cl.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(C)OC(=O)N1CCC(CO)CC1",
        "output": "343"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cn1cc(CNc2ccccc2[N+](=O)[O-])c2ccccc21.[H][H].[Pd]>>Cn1cc(CNc2ccccc2N)c2ccccc21",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOCC.COC(=O)C(CN1CCC(NC(=O)OC(C)(C)C)CC1)c1c(F)ccc2ccc(OC)nc12.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+].[Na+].[OH-]>>COc1ccc2ccc(F)c(C(CO)CN3CCC(NC(=O)OC(C)(C)C)CC3)c2n1",
        "output": "343"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CCN(C(C)C)C(C)C.CN(C)C=O.N#Cc1ccc(Cl)nc1.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCC(Nc2ccc(C#N)cn2)CC1",
        "output": "70"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)c1ccc(C=O)c2ccccc12.Nc1cccc(-c2c(Cc3ccccc3)cnc3c(C(F)(F)F)cccc23)c1>>CN(C)c1ccc(CNc2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)c2ccccc12",
        "output": "359"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(Br)c1ncnc(Cl)c1I.CCN(CC)CC.Cc1ccccc1.NCCc1ccc(OC(F)(F)F)cc1>>CC(Br)c1ncnc(NCCc2ccc(OC(F)(F)F)cc2)c1I",
        "output": "110"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CN(C)C=O.Cc1cc(Br)cc(C(=O)O)c1C.O.OB(O)c1ccc(F)c(F)c1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Cc1cc(-c2ccc(F)c(F)c2)cc(C(=O)O)c1C",
        "output": "837"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CN(C)C=O.Cl.O.O=C(O)c1cc(O)cc(Br)c1.O=C([O-])[O-].[K+].[K+]>>O=C(O)c1cc(Br)cc(OCc2ccccc2)c1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1CN(c2nn(N)c(=O)c3ccccc23)CC(C)O1.O=C(Cl)Cc1ccc(Cl)cc1>>CC1CN(c2nn(NC(=O)Cc3ccc(Cl)cc3)c(=O)c3ccccc23)CC(C)O1",
        "output": "450"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCO.Cc1ccc(-n2cccc2)c([N+](=O)[O-])c1.O.O=S([O-])S(=O)[O-].[Na+].[Na+]>>Cc1ccc(-n2cccc2)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CS(=O)(=O)OCCn1c(=O)oc2ccccc21.O=C([O-])[O-].[K+].[K+].c1ccc2c3c([nH]c2c1)CNCC3>>O=c1oc2ccccc2n1CCN1CCc2c([nH]c3ccccc23)C1",
        "output": "496"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1.CCN(CC)CC.C[C@@H](Cn1ncc2ccc3oc(CN)cc3c21)NC(=O)OCc1ccccc1.O.O=C([O-])O.[Na+]>>CC(=O)Nc1ccc(S(=O)(=O)NCc2cc3c(ccc4cnn(C[C@H](C)NC(=O)OCc5ccccc5)c43)o2)cc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN(C)C=O.COC(=O)C(C)(C)COc1cc(C)c(B2OC(C)(C)C(C)(C)O2)cn1.N#Cc1ccc(Br)cc1F.O.O=C([O-])[O-].[Na+].[Na+]>>COC(=O)C(C)(C)COc1cc(C)c(-c2ccc(C#N)c(F)c2)cn1",
        "output": "954"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)C=Cc4ccc(N)c(C)c4)c3Cl)c2n1.ClCCl>>Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)C=Cc4ccc(NS(C)(=O)=O)c(C)c4)c3Cl)c2n1",
        "output": "194"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.COC(=O)CCCSCCN1C(=O)CCC[C@@H]1/C=C/C(O)Cc1ccccc1.O=P([O-])([O-])[O-]>>O=C(O)CCCSCCN1C(=O)CCC[C@@H]1/C=C/C(O)Cc1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCN=C=O.Cc1n[nH]c2nc(-c3ccc(O)cc3F)cc(CN3CCCNC(C)C3)c12.O>>CCNC(=O)N1CCCN(Cc2cc(-c3ccc(O)cc3F)nc3[nH]nc(C)c23)CC1C",
        "output": "437"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br.CC(=O)O.COc1ccc(CCCC(=O)O)cc1>>O=C(O)CCCc1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.CN(C)C=O.O.O=C([O-])[O-].O=Cc1cnn2c(NC3CC3)cc(Cl)nc12.[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(c2cc(NC3CC3)n3ncc(C=O)c3n2)CC1",
        "output": "162"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CCCC1=O.O=S(=O)(Nc1ncc(Cl)nc1Cl)c1cccc(Cl)c1Cl.OCc1cccc(CO)n1>>O=S(=O)(Nc1ncc(Cl)nc1OCc1cccc(CO)n1)c1cccc(Cl)c1Cl",
        "output": "209"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Fc1cccc(F)c1Br.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>O=[N+]([O-])c1ccc(F)c(Br)c1F",
        "output": "103"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(C)O.CCNc1nc(Cl)ncc1C#N.CO.Cl.Nc1ccc(S(=O)(=O)NCC(O)CN2CCCCC2)cc1>>CCNc1nc(Nc2ccc(S(=O)(=O)NCC(O)CN3CCCCC3)cc2)ncc1C#N",
        "output": "808"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)[Si](C)(C)OCCCn1ccc2c3c(c(-c4ccccc4Cl)cc21)C(=O)NC3=O.O=S(=O)(O)O>>O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1c2ccn1CCCO",
        "output": "708"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)O.CCOC(=O)c1nc(CC2CCCCC2)n(-c2cccc(Cl)c2F)c1-c1ccc(F)c(Cl)c1.CCOC(C)=O.O.[BH4-].[Na+]>>OCc1nc(CC2CCCCC2)n(-c2cccc(Cl)c2F)c1-c1ccc(F)c(Cl)c1",
        "output": "286"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCn1c(C(=O)O)c(C)c2cc(F)ccc21.Cc1cc(Oc2cc(F)cc(CN)c2)ccc1OC(C)(C)C(=O)O>>CCn1c(C(=O)NCc2cc(F)cc(Oc3ccc(OC(C)(C)C(=O)O)c(C)c3)c2)c(C)c2cc(F)ccc21",
        "output": "905"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN.CN(CC(=O)O)c1ccc(NC(=O)c2nc(-c3ccccc3)oc2C(F)(F)F)cn1>>CNC(=O)CN(C)c1ccc(NC(=O)c2nc(-c3ccccc3)oc2C(F)(F)F)cn1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)C[AlH]CC(C)C.COC(=O)c1cc2cccnn2c1-c1ccccn1.Cc1ccccc1.ClCCl>>OCc1cc2cccnn2c1-c1ccccn1",
        "output": "522"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)C1(NC(=O)c2cc3ccccc3cc2NC(=O)Nc2c(Cl)cc(Cl)cc2Cl)CCSCC1.Cl.O.[Li+].[OH-]>>O=C(Nc1cc2ccccc2cc1C(=O)NC1(C(=O)O)CCSCC1)Nc1c(Cl)cc(Cl)cc1Cl",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNCC1.Fc1ccc(-n2ccc3cc(OCCCCCCCBr)ccc32)cc1>>Fc1ccc(-n2ccc3cc(OCCCCCCCN4CCCCC4)ccc32)cc1",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)c1cc(-c2ccc(C)cc2)cc(-n2cnnn2)c1.O.O.[Li]O>>Cc1ccc(-c2cc(C(=O)O)cc(-n3cnnn3)c2)cc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COc1ccc(-c2c[nH]c(C3CN(c4cc(-c5ccc(C#N)c(F)c5)nc(N)n4)CCO3)n2)cc1.NN>>COc1ccc(-c2c[nH]c(C3CN(c4cc(-c5ccc6c(N)n[nH]c6c5)nc(N)n4)CCO3)n2)cc1",
        "output": "945"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1(CCOC)CCN(S(=O)(=O)c2ccccc2Cl)CC1.CO.[Na+].[OH-]>>COCCC1(C(=O)O)CCN(S(=O)(=O)c2ccccc2Cl)CC1",
        "output": "281"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(NC(=O)OCc2ccccc2)CCNCC1.COCCOc1ccn2c(-c3ccc4c(F)ccc(Br)c4n3)cnc2c1.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COCCOc1ccn2c(-c3ccc4c(F)ccc(N5CCC(C)(NC(=O)OCc6ccccc6)CC5)c4n3)cnc2c1",
        "output": "597"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.COC(=O)c1ccc(Cc2cn(C)c3ccc(C(=O)OCc4ccccc4)cc23)c(OC)c1.O=CO.[Pd]>>COC(=O)c1ccc(Cc2cn(C)c3ccc(C(=O)O)cc23)c(OC)c1",
        "output": "290"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCOc1ccc2c(=O)c(C)c(-c3ccccc3)oc2c1C(C)=O.CCO.COc1cccc(C=O)c1.O.[K+].[OH-]>>C=CCOc1ccc2c(=O)c(C)c(-c3ccccc3)oc2c1C(=O)C=Cc1cccc(OC)c1",
        "output": "295"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.O=C(CBr)c1ccccc1O.O=[N+]([O-])O>>O=C(CBr)c1cc([N+](=O)[O-])ccc1O",
        "output": "21"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCOC(=O)Cc1ccc2c(c1)Cc1c-2[nH]c(=O)c2nccn12.Cl>>O=C(O)Cc1ccc2c(c1)Cc1c-2[nH]c(=O)c2nccn12",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1Br.CCO.O.[C-]#N.[Na+]>>N#CCc1ccccc1Br",
        "output": "39"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.ClC(Cl)Cl.O=S(=O)(Cl)c1ccc(Br)cc1>>CC(C)(C)OC(=O)N1CCC(NS(=O)(=O)c2ccc(Br)cc2)CC1",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)C1CNc2ccccc21.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCC1CNc2ccccc21",
        "output": "225"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1C(=O)[C@H](O)C(C)(C)C.CCOCC.Cl.ClCCl>>CC(C)(C)[C@@H](O)C(=O)N1CCC[C@H]1C(=O)NCc1cc(Cl)ccc1CN",
        "output": "793"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.COC(=O)[C@@H]1CCC[C@@H]1N.Cl.O=C([O-])O.O=Cc1ccc(F)cc1.O=S(=O)([O-])[O-].[BH4-].[Mg+2].[Na+].[Na+]>>COC(=O)[C@@H]1CCC[C@@H]1NCc1ccc(F)cc1",
        "output": "468"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CNCCOc1cc(Cl)c(OC)c(Cl)c1.COc1cc2c(cc1OC)CC(=O)N(CCCCl)CC2>>COc1cc2c(cc1OC)CC(=O)N(CCCN(C)CCOc1cc(Cl)c(OC)c(Cl)c1)CC2",
        "output": "138"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.C[Si](C)(C)CCOCCl.ClCCl.Clc1nc(Cl)c2c(I)c[nH]c2n1.O.[Cl-].[H-].[NH4+].[Na+]>>C[Si](C)(C)CCOCn1cc(I)c2c(Cl)nc(Cl)nc21",
        "output": "712"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1ccc(N=C=S)cc1.CO.Nc1cc([N+](=O)[O-])ccc1O>>CCc1ccc(NC(=S)Nc2cc([N+](=O)[O-])ccc2O)cc1",
        "output": "474"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)Cc1cn2c(C(=O)NCC34CC5CC(CC(C5)C3)C4)cccc2n1.[BH4-].[Li+]>>O=C(NCC12CC3CC(CC(C3)C1)C2)c1cccc2nc(CCO)cn12",
        "output": "225"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N1c2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)cc2[C@H](Nc2ccc(C(N)=O)cc2)[C@@H](C)[C@@H]1C.CO.ClCCl.O=C(O)C(F)(F)F>>CC(=O)N1c2ccc(N3CCNCC3)cc2[C@H](Nc2ccc(C(N)=O)cc2)[C@@H](C)[C@@H]1C",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.ClCCl.Cn1cc(Nc2ncc(Cl)c(NC3CNCC34CCCC4)n2)cn1.F[P-](F)(F)(F)(F)F.N#CCC(=O)O.O>>Cn1cc(Nc2ncc(Cl)c(NC3CN(C(=O)CC#N)CC34CCCC4)n2)cn1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc2c([nH]1)CCNN2C.O=C(O)c1cc2ncc(Br)cn2n1>>Cc1cc2c([nH]1)CCN(C(=O)c1cc3ncc(Br)cn3n1)N2C",
        "output": "995"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.CC(c1ccc(-c2ccccc2)c(F)c1)c1csc(NC(=S)NC(=O)c2ccccc2)n1.CO.O.O=C([O-])[O-].[K+].[K+]>>CC(c1ccc(-c2ccccc2)c(F)c1)c1csc(NC(N)=S)n1",
        "output": "80"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)/C=C/C(=O)OCC.CCOC(=O)C=[N+]=[N-].CCOC(=O)[C@@H]1C[C@H]1c1cc(F)c([N+](=O)[O-])cc1F.ClC(Cl)Cl.O=[Pt]>>CCOC(=O)[C@@H]1C[C@H]1c1cc(F)c(N)cc1F",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "O=C(Cl)Oc1ccc(Cl)cc1.[Br-].[K+].c1ccc(CCCCN2CCNCC2)cc1>>O=C(Oc1ccc(Cl)cc1)N1CCN(CCCCc2ccccc2)CC1",
        "output": "219"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCOC(=O)CBr.O=C([O-])[O-].O=C1CC2(CCCCC2)Sc2cc(O)cc(O)c21.[K+].[K+]>>CCOC(=O)COc1cc(O)c2c(c1)SC1(CCCCC1)CC2=O",
        "output": "123"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.N#Cc1ccc(F)c(C=O)c1F.O.[BH4-].[Na+]>>N#Cc1ccc(F)c(CO)c1F",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)COc1cc(C(=O)O)ccc1Cl.Cc1c(OC2CCN(C[C@H](O)CN)CC2)ccc(Cl)c1Cl>>Cc1c(OC2CCN(C[C@H](O)CNC(=O)c3ccc(Cl)c(OCC(=O)OC(C)(C)C)c3)CC2)ccc(Cl)c1Cl",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)Cn1c(-c2ccccc2)nnc1C12CC3CC(CC(C3)C1)C2.[Na+].[OH-]>>O=C(O)Cn1c(-c2ccccc2)nnc1C12CC3CC(CC(C3)C1)C2",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC(=O)Nc1ccc(OC)c(C2CCN(CCCN)CC2)c1.O=C(Cl)C(c1ccccc1)c1ccccc1>>CCCC(=O)Nc1ccc(OC)c(C2CCN(CCCNC(=O)C(c3ccccc3)c3ccccc3)CC2)c1",
        "output": "45"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.CN(C)c1ccncc1.ClCCl.O.OCCCc1cccnc1>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)OCCCc1cccnc1",
        "output": "536"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC1)CO2.CN(C)C=O.Cc1ccccc1O.O.O=C([O-])[O-].[K+].[K+]>>Cc1ccccc1OCC1(O)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "277"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=CCBr)CBr.COCCOC.OCc1ccc2c(c1)OCO2.[Na]>>CC(=CCOCc1ccc2c(c1)OCO2)CBr",
        "output": "120"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Nc1cccc(F)c1.O=C(Nc1cccc(-c2nc(NCCCN3CCOCC3)sc2-c2ccnc(Cl)n2)c1)c1c(F)cccc1F>>O=C(Nc1cccc(-c2nc(NCCCN3CCOCC3)sc2-c2ccnc(Nc3cccc(F)c3)n2)c1)c1c(F)cccc1F",
        "output": "808"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=C1CCCCc2ccc([N+](=O)[O-])cc21.[Pd]>>Nc1ccc2c(c1)C(=O)CCCC2",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Clc1nccc(-c2cccc(CNCCc3ccncc3)c2)n1.NCCc1ccc(O)c(Cl)c1>>Oc1ccc(CCNc2nccc(-c3cccc(CNCCc4ccncc4)c3)n2)cc1Cl",
        "output": "544"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCCOc1cc(CCC(=O)OC)ccc1CCCc1ccc(O)c(OC)c1.CCCCS(=O)(=O)Cl.CCN(CC)CC.CCOC(C)=O.O>>CCCCOc1cc(CCC(=O)OC)ccc1CCCc1ccc(OS(=O)(=O)CCCC)c(OC)c1",
        "output": "149"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.CCOCC.CO.COc1cccc(C(=O)N(CC=O)c2ccccc2OC)c1.O=C(c1ccc(F)cc1)C1CCNCC1.[BH3-]C#N.[Na+]>>COc1cccc(C(=O)N(CCN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc2OC)c1",
        "output": "484"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.N#Cc1ccc(Oc2cc(Br)cnc2NC(=S)NC(=O)c2ccccc2)cc1.[Na+].[OH-]>>N#Cc1ccc(Oc2cc(Br)cnc2NC(N)=S)cc1",
        "output": "80"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1c(Br)cn2cc(C[C@@H]3CCCCN3)nc2c1C.Cc1nc(C(=O)O)c(-c2ccccc2)s1.F[B-](F)(F)F.O.[Cl-].[Na+]>>Cc1nc(C(=O)N2CCCC[C@H]2Cc2cn3cc(Br)c(C)c(C)c3n2)c(-c2ccccc2)s1",
        "output": "747"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1ccc2c(c1)OCCc1sc(-c3ncnn3Cc3ccncc3)nc1-2.CC(C)(O)Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>CC(C)(O)Cn1cc(-c2ccc3c(c2)OCCc2sc(-c4ncnn4Cc4ccncc4)nc2-3)cn1",
        "output": "971"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.CS(=O)(=O)Nc1ccc(NCC(=O)O)cc1.Cl.c1ccc(OC2CCNCC2)cc1>>CS(=O)(=O)Nc1ccc(NCC(=O)N2CCC(Oc3ccccc3)CC2)cc1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCC.CCOC(C)=O.Cc1oc2c(C)c(C)c(N)c(C)c2c1-c1ccccc1.O=C(Cl)c1ccc(F)cc1>>Cc1oc2c(C)c(C)c(NC(=O)c3ccc(F)cc3)c(C)c2c1-c1ccccc1",
        "output": "11"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COCCN1CCN(c2ccc([N+](=O)[O-])cc2C)CC1.[Pd]>>COCCN1CCN(c2ccc(N)cc2C)CC1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1cc(C)c2[nH]c(=O)n(-c3cc(S(=O)(=O)C(C)(C)c4ccccc4)c(OC)cc3Cl)c2n1.CO.Cl.O.O.[Li+].[OH-]>>COc1cc(Cl)c(-n2c(=O)[nH]c3c(C)cc(C(=O)O)nc32)cc1S(=O)(=O)C(C)(C)c1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.COc1cccc(-c2nc(C(C)(C)C)co2)c1>>CC(C)(C)c1coc(-c2cccc(O)c2)n1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br.C1COCCO1.NCCBr.O.O=C(Cl)OCc1ccccc1.[Na+].[OH-]>>O=C(NCCBr)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClC(Cl)Cl.N#CBr.O=C([O-])O.[I-].[K+].[Na+].c1ccc2c(C3CCNCC3)noc2c1>>N#CN1CCC(c2noc3ccccc23)CC1",
        "output": "532"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CO.COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1.Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O>>COc1ccc(C(OC[C@H]2O[C@@H](n3cc(C)c(=O)[nH]c3=O)C[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1",
        "output": "250"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CSCCN1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(=O)COc1ccc(S(=O)(=O)n2cc(C=O)c3cc(-c4ccc(C(F)(F)F)cc4)ccc32)cc1C.ClCCl.O=C([O-])O.[Na+].[Na+]>>CCOC(=O)COc1ccc(S(=O)(=O)n2cc(CN3CCSCC3)c3cc(-c4ccc(C(F)(F)F)cc4)ccc32)cc1C",
        "output": "757"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1nc(-n2nc(Cc3ccccc3F)c3ncc(F)cc32)nc(N)c1[N+](=O)[O-].[H][H].[Pd].c1ccncc1>>Nc1nc(-n2nc(Cc3ccccc3F)c3ncc(F)cc32)nc(N)c1N",
        "output": "660"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(Cl)Cl.CCI.O.O=C(O)c1c(F)c(F)c(F)c(F)c1F.O=S(Cl)Cl.Oc1ccc(Oc2ccccc2)cc1.[Al+3].[Cl-].[Cl-].[Cl-].[Na+].[OH-]>>O=C(Cl)c1c(F)c(F)c(F)c(F)c1F",
        "output": "3"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCCCCCNC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CCCCCCCCCCNC(=O)[C@@H]1CCCN1",
        "output": "634"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COCCN(CCc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)on5)cc4F)c3s2)nc1)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>COCCNCCc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)Nc5cc(C)on5)cc4F)c3s2)nc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COC(=O)c1ccc(Nc2ccc(F)cc2)c([N+](=O)[O-])c1.Cl[Sn]Cl.O.O.O=C([O-])O.[Na+]>>COC(=O)c1ccc(Nc2ccc(F)cc2)c(N)c1",
        "output": "481"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1nnn(-c2ccc(C(F)(F)F)cn2)c1C.Cl.[Na+].[OH-]>>Cc1c(C(=O)O)nnn1-c1ccc(C(F)(F)F)cn1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cccc(N(C)C(=O)c2ccc(Br)s2)c1.OB(O)c1cccc(F)c1.[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cccc(N(C)C(=O)c2ccc(-c3cccc(F)c3)s2)c1",
        "output": "864"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CN1CCCN(c2ccc([N+](=O)[O-])cc2)CC1.[Pd]>>CN1CCCN(c2ccc(N)cc2)CC1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C=CCSc1ccccc1C(N)=O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>C=CCSc1ccccc1CN",
        "output": "215"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)Cc1c(C(=O)c2cc3c(cn2)CCCC3)[nH]c2cc(Cl)ccc12.[Na+].[OH-]>>O=C(O)Cc1c(C(=O)c2cc3c(cn2)CCCC3)[nH]c2cc(Cl)ccc12",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Brc1ccc(I)cc1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)NCCC1CCNCC1.CCOC(C)=O.Cc1ccccc1.O.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1.c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)OC(=O)NCCC1CCN(c2ccc(Br)cc2)CC1",
        "output": "931"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCS(=O)(=O)Cc1cc(N2CCOC[C@@H]2C)nc(-c2ccc(N)cc2)n1.O=C(Cl)Oc1ccccc1.O=C([O-])O.[Na+]>>CCS(=O)(=O)Cc1cc(N2CCOC[C@@H]2C)nc(-c2ccc(NC(=O)Oc3ccccc3)cc2)n1",
        "output": "102"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=C(Nc1ccccn1)N1CCc2cc([N+](=O)[O-])ccc21.O=C[O-].[C].[NH4+].[Pd]>>Nc1ccc2c(c1)CCN2C(=O)Nc1ccccn1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.CC(=O)O.CC(=O)c1ccccc1>>O=C(CBr)c1ccccc1",
        "output": "173"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)COCCN1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F.O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1>>CC1(C)COCCN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1",
        "output": "605"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CC(C)=O.CCOc1ccc(C2(CC(O)Cc3cccc(Oc4ccccc4)c3)CC2)cc1.O.O=S(=O)(O)O.O=[Cr](=O)=O>>CCOc1ccc(C2(CC(=O)Cc3cccc(Oc4ccccc4)c3)CC2)cc1",
        "output": "87"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1CC(O)(c2ccccc2)CN1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O=C(O)c1cnoc1-c1ccc(F)cc1>>CC1CC(O)(c2ccccc2)CN1C(=O)c1cnoc1-c1ccc(F)cc1",
        "output": "975"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CN(C)c1ccc(C2CC3CCCC2N3)cn1.O=C(Cl)OCC1c2ccccc2-c2ccccc21.O=C([O-])[O-].[Na+].[Na+]>>CN(C)c1ccc(C2CC3CCCC2N3C(=O)OCC2c3ccccc3-c3ccccc32)cn1",
        "output": "219"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1ccc(C=O)cc1.CO.Cl.Cl.NCCc1ccc(F)c(Cl)c1.O=C([O-])[O-].[BH4-].[K+].[K+].[Na+]>>CC(C)(C)c1ccc(CNCCc2ccc(F)c(Cl)c2)cc1",
        "output": "468"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCNC(=O)Nc1nc2cc(-c3nc(N4CCC(C)(C(=O)OCC)CC4)ns3)cc(-c3ccccn3)c2s1.CCO.[Na+].[OH-]>>CCNC(=O)Nc1nc2cc(-c3nc(N4CCC(C)(C(=O)O)CC4)ns3)cc(-c3ccccn3)c2s1",
        "output": "281"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(=O)c1coc(CO)n1.CN(C)c1ccncc1.CS(=O)(=O)Cl.ClCCl.N#N>>CCOC(=O)c1coc(COS(C)(=O)=O)n1",
        "output": "0"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CNCCN1.C1COCCO1.Cc1nc(N2CCS(=O)CC2)nc(Cl)c1C#N>>Cc1nc(N2CCS(=O)CC2)nc(N2CCNCC2)c1C#N",
        "output": "296"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OCCOCCNC(C)(C)C.CO.C[O-].[Na+]>>CC(C)(C)NCCOCCO",
        "output": "225"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(CCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2c1CCN(CC1CC1)C2)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CNCCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2c1CCN(CC1CC1)C2",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)C1=C(c2ccccc2)c2ccccc2C1c1ccc(OC)cc1.CCOC(C)=O.COc1ccc(C2c3ccccc3C(c3ccccc3)C2C(=O)[O-])cc1.[Pd]>>COc1ccc(C2c3ccccc3C(c3ccccc3)C2C(=O)O)cc1",
        "output": "151"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C(=O)OC(C)(C)C)c1cccc(-n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)c1.ClCCl.O=C(O)C(F)(F)F>>CNc1cccc(-n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)c1",
        "output": "830"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.COc1ccc2ncc(=O)n(CC=O)c2n1.ClCCl.O=C(NC[C@@H]1CCCNC1)OCc1ccccc1.O=S(=O)([O-])[O-].[Na+].[Na+].[Na+]>>COc1ccc2ncc(=O)n(CCN3CCC[C@@H](CNC(=O)OCc4ccccc4)C3)c2n1",
        "output": "484"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.COC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OC(C)(C)C.CS(=O)(=O)Cl.ClCCl.O=C([O-])O.[Na+]>>COC(=O)[C@@H]1C[C@@H](OS(C)(=O)=O)CN1C(=O)OC(C)(C)C",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOC(C)=O.CN(C)C=O.COC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OCc1ccccc1.c1c[nH]cn1>>COC(=O)[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)OCc1ccccc1",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](Cc2ccccc2)[C@@H](N)C1.COCCCCN1C(=O)C(C)(C)Oc2cc(C(F)(F)F)c(C(=O)O)cc21>>COCCCCN1C(=O)C(C)(C)Oc2cc(C(F)(F)F)c(C(=O)N[C@H]3CN(C(=O)OC(C)(C)C)CC[C@@H]3Cc3ccccc3)cc21",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1cc(C#N)ccc1N(C)c1cc2c(cn1)ncn2C.CO.ClCCl.O.[Na+].[OH-]>>CCc1cc(C(N)=O)ccc1N(C)c1cc2c(cn1)ncn2C",
        "output": "419"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)c1ccncc1.CNC.Cl.ClCCl.O.O=C(O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F.O=C([O-])[O-].[Na+].[Na+]>>CN(C)C(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C[C@H](N)C(N)=O.O=C(O)c1cc(OCC2CC2)c(Br)cn1>>CC(C)C[C@H](NC(=O)c1cc(OCC2CC2)c(Br)cn1)C(N)=O",
        "output": "738"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CCOC(C)=O.O=[N+]([O-])c1ccc(OCCN2CCCC2)c(Cl)c1.[Zn]>>Nc1ccc(OCCN2CCCC2)c(Cl)c1",
        "output": "202"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1ccccc1.CC(=O)O.CCOC(C)=O.CN(C)C=O.Cc1cc(C=O)cc(C)c1O.O.[H-].[Na+]>>Cc1cc(C=O)cc(C)c1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](C(O)c3ccc(OC)cc3)CC2)c2ncnn12.CCN(CC)CC.CS(C)=O.Cl>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](C(=O)c3ccc(OC)cc3)CC2)c2ncnn12",
        "output": "32"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(Cl)CC[N+](=O)[O-].c1ccccc1>>O=C(CC[N+](=O)[O-])c1ccccc1",
        "output": "31"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(CC)CC.COCC(=O)Cl.Cc1onc(-c2ccccc2)c1COc1ccc(N)nn1>>COCC(=O)Nc1ccc(OCc2c(-c3ccccc3)noc2C)nn1",
        "output": "527"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.N#Cc1c(Cl)c(Cl)c(Cl)c(Cl)c1C#N.O.Oc1ccccc1.[K+].[OH-]>>N#Cc1c(Cl)c(Cl)c(Oc2ccccc2)c(Cl)c1C#N",
        "output": "299"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1c(NCc2ccc(OC)c(Cl)c2)nc(SCc2ccccc2)nc1N1CCn2ccnc2C1.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.[Na+]>>COC(=O)c1c(NCc2ccc(OC)c(Cl)c2)nc(S(=O)Cc2ccccc2)nc1N1CCn2ccnc2C1",
        "output": "595"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[B-](F)(F)F.N[C@@H](Cc1cccnc1)C(=O)N1CCCC1.O=C(O)c1cc2cc(Cl)ncc2[nH]1>>O=C(N[C@@H](Cc1cccnc1)C(=O)N1CCCC1)c1cc2cc(Cl)ncc2[nH]1",
        "output": "738"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CN1CCC(n2cc(Nc3ncc(Cl)c(N(C)c4cccc([N+](=O)[O-])c4)n3)cn2)CC1.ClCCl.[Ni]>>CN1CCC(n2cc(Nc3ncc(Cl)c(N(C)c4cccc(N)c4)n3)cn2)CC1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)CC(=O)O.CCOC(C)=O.COc1c(NN)ncnc1N1CCC(c2ccc(F)cc2)CC1.ClCCl.O.O=C([O-])O.O=S(Cl)Cl.[Na+]>>COc1c(NNC(=O)CC(C)(C)C)ncnc1N1CCC(c2ccc(F)cc2)CC1",
        "output": "459"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCCCCCCCCCCCCCNC(=O)OCC(CO)CC(C)OC(=O)c1ccccc1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CCCCCCCCCCCCCCCCCCNC(=O)OCC(COS(C)(=O)=O)CC(C)OC(=O)c1ccccc1",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CCO.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)nc1.[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCC(Nc2ccc([N+](=O)[O-])cn2)CC1",
        "output": "70"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.CS(=O)(=O)Cl.O.O=Cc1cc(-c2ccc(CO)cc2)cs1.[Cl-].[Li+]>>O=Cc1cc(-c2ccc(CCl)cc2)cs1",
        "output": "713"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.N[C@@H]1CC[C@@H](Nc2cc(Nc3ccc([N+](=O)[O-])cc3)c3nccn3n2)CC1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](Nc2cc(Nc3ccc([N+](=O)[O-])cc3)c3nccn3n2)CC1",
        "output": "631"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.CCN(CC)CC.CCOC(C)=O.CN(C)c1ccncc1.C[C@@H](c1ccc(C2CCNCC2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O>>CC(=O)N1CCC(c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)CC1",
        "output": "369"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)NC[C@@H]1CN(C(=O)OC(C)(C)C)CCO[C@H]1c1ccc(Cl)c(Cl)c1.CCOC(C)=O.CI.[H-].[Na+]>>CC(=O)N(C)C[C@@H]1CN(C(=O)OC(C)(C)C)CCO[C@H]1c1ccc(Cl)c(Cl)c1",
        "output": "83"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(O)nc1C.O=S(=O)(O)O.O=[N+]([O-])O>>Cc1cc([N+](=O)[O-])c(O)nc1C",
        "output": "328"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN1CCOCC1.C[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cc1cccc(Nc2ccccc2)c1N.Cl.ClCCl.On1nnc2ccccc21>>Cc1cccc(Nc2ccccc2)c1NC(=O)[C@H](C)NC(=O)OC(C)(C)C",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1cc2cc(F)cnc2nc1C(F)(F)F.CCOC(C)=O.O.O.[Li+].[OH-]>>O=C(O)c1cc2cc(F)cnc2nc1C(F)(F)F",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)c1cc(N2CCCC2=O)cc([N+](=O)[O-])c1.[Ni]>>COC(=O)c1cc(N)cc(N2CCCC2=O)c1",
        "output": "481"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)CCNC(=O)c1cc(F)c(CSc2ncc(C(C)(C)c3ccc(Cl)c(Cl)c3)n2-c2ccc(F)c(OC)c2)c(F)c1.Cl.[Na+].[OH-]>>COc1cc(-n2c(C(C)(C)c3ccc(Cl)c(Cl)c3)cnc2SCc2c(F)cc(C(=O)NCCC(=O)O)cc2F)ccc1F",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCCn1cnc(-c2cc(C)c3nc(CCC)n(Cc4ccc(-c5ccccc5C(=O)OC(C)(C)C)cc4)c3c2)c1.ClCCl.O=C(O)C(F)(F)F>>CCCCCCn1cnc(-c2cc(C)c3nc(CCC)n(Cc4ccc(-c5ccccc5C(=O)O)cc4)c3c2)c1",
        "output": "752"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1ccc(Cl)cc1-c1nccc2ccccc12.O=S(=O)(Cl)c1ccc(-c2cnco2)cc1>>O=S(=O)(Nc1ccc(Cl)cc1-c1nccc2ccccc12)c1ccc(-c2cnco2)cc1",
        "output": "68"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1scc(Br)c1-c1ncco1.O=C(O)CN1C(=O)CCc2ncccc21>>O=C(CN1C(=O)CCc2ncccc21)Nc1scc(Br)c1-c1ncco1",
        "output": "882"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C=CCBr.C=CCC(O)C[C@H]1COC(C)(C)N1C(=O)OC(C)(C)C.[H-].[Na+]>>C=CCOC(CC=C)C[C@H]1COC(C)(C)N1C(=O)OC(C)(C)C",
        "output": "120"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCC2=NCCCN2CC1.CI.CN(CC(=O)O)C(=O)OC(C)(C)C.c1ccccc1>>COC(=O)CN(C)C(=O)OC(C)(C)C",
        "output": "415"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.Cc1nc(C(C)(CO)NC(=O)c2cc(OCC(F)(F)F)c(C3CC3)cn2)no1.ClCCl>>Cc1nc(C(C)(C=O)NC(=O)c2cc(OCC(F)(F)F)c(C3CC3)cn2)no1",
        "output": "142"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CCO.CCOC(C)=O.O=C(O)C[C@@H]1CSC(c2cc3cc(F)cc(NC4CCCC4)c3[nH]2)=N1>>CCOC(=O)C[C@@H]1CSC(c2cc3cc(F)cc(NC4CCCC4)c3[nH]2)=N1",
        "output": "47"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.NCc1cc(Cl)cc2c1ncn2C1CCCCO1>>CC(C)(C)OC(=O)NCc1cc(Cl)cc2c1ncn2C1CCCCO1",
        "output": "686"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1cncc(-n2cnnn2)c1.O.[Li+].[OH-]>>O=C(O)c1cncc(-n2cnnn2)c1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)O.CCOC(C)=O.COc1ccc(S(=O)(=O)N(CCOC2CCCCO2)c2ccc(Cl)cc2C(O)c2ccccc2Cl)cc1OC.O>>COc1ccc(S(=O)(=O)N(CCO)c2ccc(Cl)cc2C(O)c2ccccc2Cl)cc1OC",
        "output": "543"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCCc1ccccc1.CN(C)C=O.NC(=O)c1ccc(Oc2ccc3c(c2)CCNCC3)nc1.O=C([O-])[O-].[K+].[K+]>>NC(=O)c1ccc(Oc2ccc3c(c2)CCN(CCc2ccccc2)CC3)nc1",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N1CCn2c1nc1c2c(=O)n(CCCC[C@@H](C)O[Si](C)(C)C(C)(C)C)c(=O)n1C.CCN(CC)CC.CCOCC.CO.Cl.O>>CC(=O)N1CCn2c1nc1c2c(=O)n(CCCC[C@@H](C)O)c(=O)n1C",
        "output": "708"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCI.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].Oc1ccc2c(-c3cccnc3)csc2c1.[K+].[K+]>>CCCCCOc1ccc2c(-c3cccnc3)csc2c1",
        "output": "198"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)C1CCN(c2ncccc2-c2ccc(Cl)c(C(=O)O)c2)CC1.NCC1CCCCCC1>>COC(=O)C1CCN(c2ncccc2-c2ccc(Cl)c(C(=O)NCC3CCCCCC3)c2)CC1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C/C=C\\c1cc(C(O)(C(F)(F)F)C(F)(F)F)ccc1N1CCN(CCOCc2ccccc2)CC1.CCN(C(C)C)C(C)C.COCCl.ClCCl.O>>C/C=C\\c1cc(C(OCOC)(C(F)(F)F)C(F)(F)F)ccc1N1CCN(CCOCc2ccccc2)CC1",
        "output": "598"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CC[C@H](C)[C@@H](CO)N(C)Cc1ccccc1.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC[C@H](C)[C@@H](C=O)N(C)Cc1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=[N+]([O-])c1ccc(F)c(F)c1.Oc1ccc(C(F)(F)F)cc1C(F)(F)F>>O=[N+]([O-])c1ccc(Oc2ccc(C(F)(F)F)cc2C(F)(F)F)c(F)c1",
        "output": "564"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)CC(=O)O.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.Fc1cc(-n2cnnn2)ccc1-c1ccc2oc(C3CCNCC3)nc2c1.O.O=C(O)C(F)(F)F.On1nnc2ccccc21>>CC(C)CC(=O)N1CCC(c2nc3cc(-c4ccc(-n5cnnn5)cc4F)ccc3o2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCC.CCOC(C)=O.CO.C[Si](C)(C)C=[N+]=[N-].Cc1ccccc1.N#N.O=C(O)c1ccc(CBr)cc1>>COC(=O)c1ccc(CBr)cc1",
        "output": "195"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)N1CCNCC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1>>CC(C)N1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.O=C(O)Cc1c[nH]c2ccccc12.O=C1CCC(c2ccccc2)(c2ccccc2)C2CNCC12>>O=C1CCC(c2ccccc2)(c2ccccc2)C2CN(C(=O)Cc3c[nH]c4ccccc34)CC12",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COC(=O)c1ccc(NC(=O)C(C)(C)C)nc1NC(=O)C(C)(C)C.O=C1CCC(=O)N1Cl>>COC(=O)c1cc(Cl)c(NC(=O)C(C)(C)C)nc1NC(=O)C(C)(C)C",
        "output": "743"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C[C@H](N)Cn1cc(-c2ccc(F)c(F)c2)cn1.Cc1ccc(-n2nccn2)c(C(=O)O)n1.Cl>>Cc1ccc(-n2nccn2)c(C(=O)N[C@@H](C)Cn2cc(-c3ccc(F)c(F)c3)cn2)n1",
        "output": "137"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CCC(=O)[O-])C(=O)[O-]>>CCNC(=O)CC[C@H](N)C(=O)O",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N1CCC([C@@H](C)C(=O)O)CC1.Nc1ccc(-c2cc(F)cc(F)c2)cc1>>CC(=O)N1CCC([C@@H](C)C(=O)Nc2ccc(-c3cc(F)cc(F)c3)cc2)CC1",
        "output": "365"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Br.CS(=O)(=O)OCCc1cc2cc(-c3cccc(C#N)c3)ccc2o1.C[C@H]1CCCN1>>C[C@H]1CCCN1CCc1cc2cc(-c3cccc(C#N)c3)ccc2o1",
        "output": "496"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.NN.O=C1c2ccccc2C(=O)N1Cc1c(-c2ccccc2)nc2ncccc2c1-c1ccccc1>>NCc1c(-c2ccccc2)nc2ncccc2c1-c1ccccc1",
        "output": "242"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1cccc(C(C)=O)c1.COC(OC)N(C)C.Cc1ccccc1>>COC(=O)c1cccc(C(=O)C=CN(C)C)c1",
        "output": "576"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.COCOC1(c2ncc(-c3c(Cl)cnc4c3cc(-c3ccc(C=O)c(F)c3)n4S(=O)(=O)c3ccc(C)cc3)s2)CCC1.Cl.ClCCl.FC1CCNCC1.[Na+]>>COCOC1(c2ncc(-c3c(Cl)cnc4c3cc(-c3ccc(CN5CCC(F)CC5)c(F)c3)n4S(=O)(=O)c3ccc(C)cc3)s2)CCC1",
        "output": "567"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.O=C(NCCCCO)OCc1ccccc1>>CS(=O)(=O)OCCCCNC(=O)OCc1ccccc1",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1c2cc(Cl)nc(=O)n2CC1(C)C.OCc1cc(F)c(F)c(F)c1>>CN1c2cc(OCc3cc(F)c(F)c(F)c3)nc(=O)n2CC1(C)C",
        "output": "653"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.O=[Pt]=O.OCCCCCCC#Cc1ccc(Cl)c(Cl)c1>>OCCCCCCCCc1ccc(Cl)c(Cl)c1",
        "output": "717"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.OCc1cn(Cc2ccc3cc(OCc4ccccc4)ccc3c2)cc1-c1ccccc1.[Mn+4].[O-2].[O-2]>>O=Cc1cn(Cc2ccc3cc(OCc4ccccc4)ccc3c2)cc1-c1ccccc1",
        "output": "520"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCc1ccc(Cn2c(=Nc3ccc(OC(C)C)c(C)c3)[nH]c(=O)n(C[C@H](C)C(=O)OC)c2=O)cc1.CO.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li+].[OH-]>>CCc1ccc(Cn2c(=Nc3ccc(OC(C)C)c(C)c3)[nH]c(=O)n(C[C@H](C)C(=O)O)c2=O)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(O)CC(C)O.O=C(Cl)c1ccccc1.c1ccncc1>>CC(O)CC(C)OC(=O)c1ccccc1",
        "output": "51"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.Cc1nnn(-c2ccc([N+](=O)[O-])cc2)n1.[Pd]>>Cc1nnn(-c2ccc(N)cc2)n1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CN(C)C1(c2ccccc2)CCC(CNC(=O)Oc2ccccc2)CC1.COc1ccc2[nH]cc(C3CCNCC3)c2c1>>COc1ccc2[nH]cc(C3CCN(C(=O)NCC4CCC(c5ccccc5)(N(C)C)CC4)CC3)c2c1",
        "output": "525"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1CN(C(=O)OC(C)(C)C)CCN1.Cc1ccccc1.FC(F)(F)c1ccc(Br)cc1.c1ccc(-c2ccccc2P(C2CCCCC2)C2CCCCC2)cc1>>CC1CN(C(=O)OC(C)(C)C)CCN1c1ccc(C(F)(F)F)cc1",
        "output": "294"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Cn1c(SCCNC(=O)OC(C)(C)C)nc2ccccc21.Cl.O.[Na+].[OH-]>>CC(C)(C)OC(=O)NCCSc1nc2ccccc2n1CC(=O)O",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Cc1ccc(S(=O)(=O)O)cc1.O.O=C1CC(C(=O)O)CC(O)=C1N=Nc1ccccc1.c1ccccc1>>COC(=O)C1CC(=O)C(N=Nc2ccccc2)=C(O)C1",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(C)(C)OC(=O)N[C@H](CSc1ccc2cc(Cl)ccc2c1)C(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.Cc1ncc2n1C(=O)N(C1CCNCC1)C2.Cl.Cl.On1nnc2ccccc21>>Cc1ncc2n1C(=O)N(C1CCN(C(=O)[C@@H](CSc3ccc4cc(Cl)ccc4c3)NC(=O)OC(C)(C)C)CC1)C2",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COCOc1cc(CCc2ccc(OCC3CC3)cc2)ccc1C(=O)OC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>COCOc1cc(CCc2ccc(OCC3CC3)cc2)ccc1CO",
        "output": "444"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3cccc(CN(C)C)c3)ncc2c1=O.CN.CO>>CNC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3cccc(CN(C)C)c3)ncc2c1=O",
        "output": "498"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)N.Cc1onc(-c2cccc(Cl)c2)c1COc1ccc(C(=O)O)cn1.Cc1onc(-c2ccncn2)c1COc1ccc(C(=O)O)cn1>>Cc1onc(-c2ccncn2)c1COc1ccc(C(=O)NC(C)C)cn1",
        "output": "674"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1cn(-c2ccccc2C)c2ccccc12.[Na+].[OH-]>>Cc1ccccc1-n1cc(C(=O)O)c2ccccc21",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCCCCCCCCCCCCCC(=O)Cl.CN(C)C=O.NCC(O)CO.c1ccncc1>>CCCCCCCCCCCCCCCCCC(=O)NCC(O)CO",
        "output": "45"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)C(=O)Nc1cccc(Br)c1.O=S(=O)(O)O.O=S(=O)=O.O=[N+]([O-])O>>CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(Br)c1",
        "output": "21"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.CC(C)=O.COc1ccc(CCC(=O)C(F)(F)F)cc1.ClCCl.O=C=O>>O=C(CCc1ccc(O)cc1)C(F)(F)F",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCOCC.CCc1cc(-c2noc(C)n2)c(C)nc1OC.C[Si](C)(C)Cl.O.[I-].[Na+]>>CCc1cc(-c2noc(C)n2)c(C)[nH]c1=O",
        "output": "758"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.COC(=O)c1csc(C(C)=O)c1OC(=O)c1ccccc1.ClC(Cl)(Cl)Cl>>COC(=O)c1csc(C(=O)CBr)c1OC(=O)c1ccccc1",
        "output": "173"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1ccccc1O.Clc1ccc(-c2coc(CCCI)n2)cc1.O.O=C([O-])[O-].[K+].[K+]>>COc1ccccc1OCCCc1nc(-c2ccc(Cl)cc2)co1",
        "output": "198"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1c(C(=O)[O-])sc2nc(Cc3ccc(Cl)c(Cl)c3)[nH]c(=O)c12.Cl.O.[Na+].[Na+].[OH-]>>Cc1c(C(=O)O)sc2nc(Cc3ccc(Cl)c(Cl)c3)[nH]c(=O)c12",
        "output": "151"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.C[Si](C)(C)C#Cc1ccc(C=O)c(F)c1.O=C([O-])[O-].[K+].[K+]>>C#Cc1ccc(C=O)c(F)c1",
        "output": "337"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCC.CCCCCCC(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COC(=O)[C@@H](N)CO.ClCCl.F[P-](F)(F)(F)(F)F.On1nnc2ccccc21>>CCCCCCC(=O)N[C@@H](CO)C(=O)OC",
        "output": "129"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCNC.O=C(CCl)Nc1ccccc1[N+](=O)[O-].c1ccccc1>>CCCCN(C)CC(=O)Nc1ccccc1[N+](=O)[O-]",
        "output": "340"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCS(=O)(=O)Nc1ccc(S(=O)(=O)Cl)cc1.COc1cc(OC)cc(N2CCN(Cc3ccccc3)C(CN)C2)c1>>CCS(=O)(=O)Nc1ccc(S(=O)(=O)NCC2CN(c3cc(OC)cc(OC)c3)CCN2Cc2ccccc2)cc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "N[C@H]1CCS[C@H]2CC[C@H](C(F)(F)F)CN2C1=O.O=C(N[C@H]1CCS[C@H]2CC[C@@H](C(F)(F)F)CN2C1=O)OCc1ccccc1>>N[C@H]1CCS[C@H]2CC[C@@H](C(F)(F)F)CN2C1=O",
        "output": "128"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.CCOC(C)=O.CO.COCCS(=O)(=O)Nc1ccc2c(c1)CCNC2.Cl.O.O=C(O)COc1cccnc1.[Cl-].[Na+]>>COCCS(=O)(=O)Nc1ccc2c(c1)CCN(C(=O)COc1cccnc1)C2",
        "output": "633"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cl.Nc1cc(Cl)ccc1C(=O)O>>COC(=O)c1ccc(Cl)cc1N",
        "output": "33"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1ccc(OCc2ccccc2)cc1.C1CCOC1.CC1(C)CCC(=O)CC1.II.[Mg]>>CC1(C)CCC(O)(c2ccc(OCc3ccccc3)cc2)CC1",
        "output": "321"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.O=c1[nH]cnc2cc(F)cc(F)c12.OCc1ccccc1.[H-].[Na+]>>O=c1[nH]cnc2cc(F)cc(OCc3ccccc3)c12",
        "output": "958"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O.O=[N+]([O-])c1cccc2ccc(Br)cc12.[Fe]>>Nc1cccc2ccc(Br)cc12",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)C(C)CNC(=O)OCc1ccc(OC)cc1.[Li].[OH-]>>COc1ccc(COC(=O)NCC(C)C(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.ClCCl.NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(C3CCCCN3)cc2)ncc1C(F)(F)F.[Na+]>>CN1CCCCC1c1ccc(Nc2ncc(C(F)(F)F)c(CCc3ccccc3CC(N)=O)n2)cc1",
        "output": "69"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.COC(=O)c1ccc2c(c1)C(C)(C)CC(c1cccc(Br)c1)N2.CS(C)=O.O.O=C(O)[C@@H]1CCCN1.[Cu]I>>COC(=O)c1ccc2c(c1)C(C)(C)CC(c1cccc(N3CCOCC3)c1)N2",
        "output": "953"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)c1ccc(O)c(C)c1O.CC(C)OC(=O)/N=N/C(=O)OC(C)C.CCOC(C)=O.N#Cc1ccc(Sc2cccc(CO)c2)cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(=O)c1ccc(OCc2cccc(Sc3ccc(C#N)nc3)c2)c(C)c1O",
        "output": "347"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1cn(C)c(=O)cc1Nc1ccc(CC)cc1F.[Na+].[OH-]>>CCc1ccc(Nc2cc(=O)n(C)cc2C(=O)O)c(F)c1",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)N1CCc2ccc3c(c2CC1)C(CC)CCO3.Cl.O.[K+].[OH-]>>CCC1CCOc2ccc3c(c21)CCNCC3",
        "output": "283"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Nc1ccccc1N.O=C=NC1CCCCC1.c1ccccc1>>Nc1ccccc1NC(=O)NC1CCCCC1",
        "output": "176"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)O)CC1.CC[C@@H](N)c1ccccc1>>CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)N[C@H](CC)c2ccccc2)CC1",
        "output": "599"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)NC1CCN(c2ccc([N+](=O)[O-])cc2)CC1.CI.[Cl-].[H-].[NH4+].[Na+]>>CC(=O)N(C)C1CCN(c2ccc([N+](=O)[O-])cc2)CC1",
        "output": "83"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.CCOC(C)=O.COC(=O)Cc1cc(C)cc(S(=O)(=O)Cl)c1.O=C1CCC(=O)N1Br.c1ccccc1>>COC(=O)Cc1cc(CBr)cc(S(=O)(=O)Cl)c1",
        "output": "29"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C(O)Cc1cc(Cl)cc(Br)c1.O=S(=O)(O)O>>COC(=O)Cc1cc(Cl)cc(Br)c1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC=O.COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCNCc2ccc(C)cc2)CC1.[BH3-]C#N.[Na+]>>CCN(CCCCCN1CCC(CNC(=O)c2cc(Cl)c(N)cc2OC)CC1)Cc1ccc(C)cc1",
        "output": "858"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CCCNC1.CCN(C(C)C)C(C)C.CCOCC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNc1ccc(C(=O)O)cc1[N+](=O)[O-].F[P-](F)(F)(F)(F)F.O>>CNc1ccc(C(=O)N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)cc1[N+](=O)[O-]",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.C[O-].Fc1cc(C(F)(F)F)ccc1C=Cc1nc(CCl)co1.Oc1ccc(CCCCn2ccnn2)cc1.[I-].[K+].[Na+]>>Fc1cc(C(F)(F)F)ccc1/C=C/c1nc(COc2ccc(CCCCn3ccnn3)cc2)co1",
        "output": "760"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COc1cc([N+](=O)[O-])ccc1-c1cnc2ccnn2c1N.[Ni]>>COc1cc(N)ccc1-c1cnc2ccnn2c1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCC.CCOC(=O)c1cccc(Br)n1.CCOC(C)=O.OCC(C1CCCCC1)n1c(-c2ccc(Cl)cc2)nc2cc(F)c(F)cc21>>CCOC(=O)c1cccc(OCC(C2CCCCC2)n2c(-c3ccc(Cl)cc3)nc3cc(F)c(F)cc32)n1",
        "output": "551"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[O-].COc1cccc(-c2ccc(F)c(C#N)c2)c1.CS(C)=O.Nc1ccncc1.[K+]>>COc1cccc(-c2ccc(Nc3ccncc3)c(C#N)c2)c1",
        "output": "609"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1N.CCCc1cc(C)cc(Nc2cc(Cl)nnc2C(N)=O)n1.CCOC(C)=O.CN1CCCC1=O.O.[Cl-].[Na+]>>CCCc1cc(C)cc(Nc2cc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)nnc2C(N)=O)n1",
        "output": "241"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CN(C(=O)OCC(C)(C)C(=O)OC)C2CC2)C(C)C)ccc1OC.O>>COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CN(C(=O)OCC(C)(C)C(=O)O)C2CC2)C(C)C)ccc1OC",
        "output": "361"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CNC(=O)c1cc(Oc2ccc(N=[CH2+]c3cc(C(C)(C)C)nn3-c3cccc(CO)c3)c(F)c2)ccn1.CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3cccc(CO)c3)c(F)c2)ccn1.COCC(=O)Cl.ClCCl.c1ccncc1>>CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3cccc(COC(=O)COC)c3)c(F)c2)ccn1",
        "output": "126"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(CC=C(C)CCCC(C)COC1CCCCO1)C(C)=Cc1csc(C)n1.CCO.Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1>>CC(=O)OC(CC=C(C)CCCC(C)CO)C(C)=Cc1csc(C)n1",
        "output": "543"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2cn[nH]c2c1.c1ccc2c(c1)C[C@@H]1NCCC[C@H]21>>O=C(c1ccc2cn[nH]c2c1)N1CCC[C@@H]2c3ccccc3C[C@@H]21",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1sc2ncccc2c1NC(=O)CC(C)C.[Li+].[OH-]>>CC(C)CC(=O)Nc1c(C(=O)O)sc2ncccc12",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)c1ccccc1OC1CNC1.O=S(=O)(Cl)c1ccccc1.c1ccncc1>>CC(C)(C)c1ccccc1OC1CN(S(=O)(=O)c2ccccc2)C1",
        "output": "99"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.O=Cc1cccc(O)c1.OCCc1ccccn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=Cc1cccc(OCCc2ccccn2)c1",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)/C=C/C(=O)c1nn(-c2cccc(S(=O)(=O)N3CCCC3)c2)ccc1=O.NNc1ccccc1F>>O=c1ccn(-c2cccc(S(=O)(=O)N3CCCC3)c2)nc1-c1ccnn1-c1ccccc1F",
        "output": "984"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Nc1nc(C)c(-c2cc(S(=O)(=O)Cl)sc2Br)s1.CCN(CC)CC.CN1CCC(N)CC1.ClCCl>>CC(=O)Nc1nc(C)c(-c2cc(S(=O)(=O)NC3CCN(C)CC3)sc2Br)s1",
        "output": "600"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CNCCc1ccc(Oc2ccc(O)cc2)cc1.ClCCCl.O=Cc1ccccc1.[Na+]>>CN(CCc1ccc(Oc2ccc(O)cc2)cc1)Cc1ccccc1",
        "output": "567"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1CN(C(=O)OC(C)(C)C)CCN1.CCOC(C)=O.Cc1ccccc1.FC(F)(F)c1ccc(Br)cc1.c1ccc(-c2ccccc2P(C2CCCCC2)C2CCCCC2)cc1>>CC1CN(C(=O)OC(C)(C)C)CCN1c1ccc(C(F)(F)F)cc1",
        "output": "294"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.COc1ccc(C=O)cc1OC.NNc1ccc(-c2cnco2)cc1>>COc1ccc(C=NNc2ccc(-c3cnco3)cc2)cc1OC",
        "output": "167"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCc1cccc(CN(Cc2ccc(C(F)(F)F)cc2)S(=O)(=O)c2cc(Cl)cc(Cl)c2O)c1.ClCCl.O=C(O)C(F)(F)F>>NCc1cccc(CN(Cc2ccc(C(F)(F)F)cc2)S(=O)(=O)c2cc(Cl)cc(Cl)c2O)c1",
        "output": "793"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNOC.C[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.F[P-](F)(F)(F)(F)F.O>>CON(C)C(=O)[C@H](C)NC(=O)OC(C)(C)C",
        "output": "54"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.Nc1ccc2c(c1)N(C1CCN(CCc3ccc(F)cc3)CC1)CC2.O=C1CCC(=O)N1Cl>>Nc1cc2c(cc1Cl)CCN2C1CCN(CCc2ccc(F)cc2)CC1",
        "output": "121"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)[Si](OCCC1(c2ccccc2)SC(c2cc(F)ccc2F)=NN1c1nc2c(s1)CNCC2)(c1ccccc1)c1ccccc1.ClCCCl.O=C([O-])[O-].[Na+].[Na+].[Na+]>>CN1CCc2nc(N3N=C(c4cc(F)ccc4F)SC3(CCO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)c3ccccc3)sc2C1",
        "output": "217"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.OCCO.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCO",
        "output": "193"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCCc1ccc2c(c1)OCO2.CC#N.CNC(C)(C)CCC(C(N)=O)(c1ccccc1)c1ccccc1.O=C([O-])[O-].[K+].[K+]>>CN(CCc1ccc2c(c1)OCO2)C(C)(C)CCC(C(N)=O)(c1ccccc1)c1ccccc1",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)c1ccc(Nc2cc3c4c(c2)CCCC4CCC3)cc1.Cl.[Na+].[OH-]>>O=C(O)c1ccc(Nc2cc3c4c(c2)CCCC4CCC3)cc1",
        "output": "5"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "B#B.C1CCOC1.CCOC(=O)c1ccc(NC(=O)C(C)Oc2ccc(Cl)c3ccccc23)cc1>>CCOC(=O)c1ccc(NCC(C)Oc2ccc(Cl)c3ccccc23)cc1",
        "output": "112"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.ClCCl.O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@H]2CN(C3CNC3)CCO2)CC1>>CC(=O)N1CC(N2CCO[C@@H](CN3CCN(C(=O)Nc4ccc(Cl)c(Cl)c4)CC3)C2)C1",
        "output": "369"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "NCC1CCOCC1.Nc1cccnc1C(=O)O>>Nc1cccnc1C(=O)NCC1CCOCC1",
        "output": "137"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)Cl.Cc1ccc2c(c1)c(-c1ccc(F)cc1)cn2C1CCN(CCN)CC1.ClCCl.O=C([O-])[O-].[K+].[K+]>>COC(=O)NCCN1CCC(n2cc(-c3ccc(F)cc3)c3cc(C)ccc32)CC1",
        "output": "94"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc2nccc(CCC(N)CCC3CN(c4ccc5c(c4)OCCO5)C(=O)O3)c2n1.CS(=O)(=O)Cl.ClCCl>>COc1ccc2nccc(CCC(CCC3CN(c4ccc5c(c4)OCCO5)C(=O)O3)NS(C)(=O)=O)c2n1",
        "output": "493"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC(=O)Oc1cc(C(C)C)c(Oc2ccc([N+](=O)[O-])c(O)c2)c(C(C)C)c1C.CO.[H][H].[Pd]>>CCC(=O)Oc1cc(C(C)C)c(Oc2ccc(N)c(O)c2)c(C(C)C)c1C",
        "output": "335"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.Cl.Fc1cc(CO[C@H]2CCNC[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1.O>>CS(=O)(=O)N1CC[C@H](OCc2cc(F)cc(C(F)(F)F)c2)[C@H](C(c2ccccc2)c2ccccc2)C1",
        "output": "584"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(Cl)Cl.CCN=C=NCCC[N+](C)(C)C.CN(C)C=O.COCCN.Cc1cc(-c2cc(-c3cccc(C(=O)O)c3)[nH]c(=O)n2)ccc1O.On1nnc2ccccc21.[I-]>>COCCNC(=O)c1cccc(-c2cc(-c3ccc(O)c(C)c3)nc(=O)[nH]2)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC1Cc2cc(OCC(=O)O)c(Cl)c(Cl)c2C1=O.Cl.O.[BH4-].[K+]>>CCC1Cc2cc(OCC(=O)O)c(Cl)c(Cl)c2C1O",
        "output": "24"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.O=C(O)CNC(CO)(CO)CO.O=S(=O)(O)O>>CCOC(=O)CNC(CO)(CO)CO",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.CCCC(CCC)c1ccc(O)cc1.CCOC(C)=O.O.O=C([O-])[O-].O=Cc1ccc(-c2ccc(CCl)cc2)s1.[I-].[K+].[K+].[K+]>>CCCC(CCC)c1ccc(OCc2ccc(-c3ccc(C=O)s3)cc2)cc1",
        "output": "49"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.Cl.N#Cc1ccc2c(c1)c(-c1cc3ccccc3o1)nn2C1CCCCO1>>N#Cc1ccc2[nH]nc(-c3cc4ccccc4o3)c2c1",
        "output": "689"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1ccccc1C(=O)O.O=C1OC(=O)c2c1cccc2[N+](=O)[O-]>>O=C(O)c1ccccc1N1C(=O)c2cccc([N+](=O)[O-])c2C1=O",
        "output": "475"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cnn(C)c1C(=O)Nc1ccn2nc(Br)nc2c1.CO.O.O.[Li+].[OH-]>>Cn1ncc(C(=O)O)c1C(=O)Nc1ccn2nc(Br)nc2c1",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrC(Br)(Br)Br.CCOC(=O)c1cc(C2CC2)c2c(C)c(-c3ccc(CO)cc3)ccn2c1=O.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1cc(C2CC2)c2c(C)c(-c3ccc(CBr)cc3)ccn2c1=O",
        "output": "750"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CC(=O)O[Cu]OC(C)=O.Cc1ccc(B(O)O)cc1C.O=C([O-])[O-].O=S1(=O)CCN2CCC[C@@H](c3ccc(O)cc3)C2=N1.[Cs+].[Cs+].c1ccncc1>>Cc1ccc(Oc2ccc([C@@H]3CCCN4CCS(=O)(=O)N=C34)cc2)cc1C",
        "output": "920"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CN1CCn2c1cc(Cl)nc2=O.N#Cc1ccc(Oc2ccc(CO)cc2F)cc1Cl.[H-].[Na+]>>CN1CCn2c1cc(OCc1ccc(Oc3ccc(C#N)c(Cl)c3)c(F)c1)nc2=O",
        "output": "653"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CON.Cc1cc(Br)c([N+](=O)[O-])cc1C=O.Cl>>CON=Cc1cc([N+](=O)[O-])c(Br)cc1C",
        "output": "30"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C1COCCN1.CCOC(C)=O.O=C(O)Cc1ccccc1CCl>>O=C(O)Cc1ccccc1CN1CCOCC1",
        "output": "156"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(C(=O)OC)cc34)cc2)no1.[Li+].[OH-]>>CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(C(=O)O)cc34)cc2)no1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrP(Br)Br.CCOCC.COc1ccc(OC)c(C(C)CCO)c1>>COc1ccc(OC)c(C(C)CCBr)c1",
        "output": "301"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CO.C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)[C@@H]1CC[C@H](Nc2cc(OCCN3CCCCC3)ncc2[N+](=O)[O-])CC1.Cl[Sn]Cl>>C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1C(=O)[C@H]1CC[C@@H](Nc2cc(OCCN3CCCCC3)ncc2N)CC1",
        "output": "269"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.Cl.F[P-](F)(F)(F)(F)F.NS(=O)(=O)c1ccc(C(=O)N2C[C@H]3CNC[C@@H]3C2)cc1.O=C(O)CCc1ccc(OC(F)(F)F)cc1>>NS(=O)(=O)c1ccc(C(=O)N2C[C@H]3CN(C(=O)CCc4ccc(OC(F)(F)F)cc4)C[C@@H]3C2)cc1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.ClCCl.Nc1cccc(N)c1.[Na+].[OH-]>>CC(C)(C)OC(=O)Nc1cccc(N)c1",
        "output": "735"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)Cn1c(=O)n(C)c(=O)c2c(-c3cc(C(=O)O)cn3C)n(Cc3c[nH]c4ccc(Cl)cc34)nc21.CC(C)N.CCOP(=O)(C#N)OCC>>CC(C)Cn1c(=O)n(C)c(=O)c2c(-c3cc(C(=O)NC(C)C)cn3C)n(Cc3c[nH]c4ccc(Cl)cc34)nc21",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Br.CCOC(C)=O.CCn1cc(C(=O)OC)c2cc(N)c(OC)cc2c1=O.O.O=N[O-].O=S(=O)(O)O.[Cu]Br.[Na+]>>CCn1cc(C(=O)OC)c2cc(Br)c(OC)cc2c1=O",
        "output": "373"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)CNc1c([N+](=O)[O-])cnc2cc(Br)ccc12.CC(C)O.O.O=S([O-])S(=O)[O-].[Na+].[Na+]>>CC(C)CNc1c(N)cnc2cc(Br)ccc12",
        "output": "269"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN1CCCOc2ccc([N+](=O)[O-])cc21.CCO.NN.O.[Pd]>>CCN1CCCOc2ccc(N)cc21",
        "output": "202"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CO.COC(=O)c1ccc2sc(/C=C/c3cccc([N+](=O)[O-])c3)nc2c1.O.[Ca+2].[Cl-].[Cl-].[Zn]>>COC(=O)c1ccc2sc(/C=C/c3cccc(N)c3)nc2c1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cc1cnc(C=O)c(C)c1.NCCCCO.[BH4-].[Na+]>>Cc1cnc(CNCCCCO)c(C)c1",
        "output": "775"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Cl[Sn]Cl.Nc1nccc(Oc2cc(F)c([N+](=O)[O-])cc2F)c1I.O.O>>Nc1cc(F)c(Oc2ccnc(N)c2I)cc1F",
        "output": "335"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)c1cn(-c2ccc(CO)cc2)c2c(Cl)c(F)c(F)cc2c1=O.CCOC(C)=O.CS(C)=O.c1ccc(N2CCNCC2)nc1>>CCOC(=O)c1cn(-c2ccc(CO)cc2)c2c(Cl)c(N3CCN(c4ccccn4)CC3)c(F)cc2c1=O",
        "output": "676"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)COc1ccc(C(=O)c2cccs2)c2c1CCCC2.O.[K+].[OH-]>>O=C(O)COc1ccc(C(=O)c2cccs2)c2c1CCCC2",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.N[C@@H]1CC[C@@H](c2ccccc2)CC1.O=C=Nc1ccc(F)cc1>>O=C(Nc1ccc(F)cc1)N[C@@H]1CC[C@@H](c2ccccc2)CC1",
        "output": "35"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(N=C=O)c1cccc(Cl)c1.CCCCCC.CCCCCNC.[C-]#N>>CCCCCN(C)C(=O)NC(C)(C)c1cccc(Cl)c1",
        "output": "583"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2nc(-c3cc4ccccc4[nH]c3=O)cs2)cc1.ClCCl.O=C(O)C(F)(F)F>>Nc1ccc(-c2nc(-c3cc4ccccc4[nH]c3=O)cs2)cc1",
        "output": "782"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCOC(C)=O.CS(C)=O.Cc1cnc(-c2cc(Cl)ncc2Cl)c(C)c1.[Cs+].[F-]>>Cc1cnc(-c2cc(N3CCN(C(=O)OC(C)(C)C)CC3)ncc2Cl)c(C)c1",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CNCC12CC2.CS(C)=O.Cc1c(F)c(F)c(N)c2c(=O)c(C(=O)O)cn(C3CC3)c12>>Cc1c(N2C[C@@H](NC(=O)OC(C)(C)C)C3(CC3)C2)c(F)c(N)c2c(=O)c(C(=O)O)cn(C3CC3)c12",
        "output": "676"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cn1c(NCc2ccccc2)ncc(-c2ccc(OCc3ccccc3)c(F)c2)c1=O.O=C(O)C(F)(F)F>>Cn1c(NCc2ccccc2)ncc(-c2ccc(O)c(F)c2)c1=O",
        "output": "23"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCP(=O)(CCC)c1cccc([N+](=O)[O-])c1.CO.N#N.[Pd]>>CCCP(=O)(CCC)c1cccc(N)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)NC1CCNC1.CCN(CC)CC.O=c1c2cc(F)c(F)cc2n(-c2cc(F)c(F)cc2F)c(=O)n1OCc1ccccc1>>CC(C)(C)OC(=O)NC1CCN(c2cc3c(cc2F)c(=O)n(OCc2ccccc2)c(=O)n3-c2cc(F)c(F)cc2F)C1",
        "output": "676"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrBr.ClC(Cl)(Cl)Cl.FC1(F)Oc2ccccc2O1.O.[Fe]>>FC1(F)Oc2ccc(Br)cc2O1",
        "output": "98"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.Cn1ccc(-c2ccc(CO)cc2)n1.O.O=C([O-])O.O=S(Cl)Cl.[Na+]>>Cn1ccc(-c2ccc(CCl)cc2)n1",
        "output": "81"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc(C)cc(B(O)O)c1O.COc1ccc(O)c(-c2cccc(-c3cccc(Br)n3)n2)c1>>COc1ccc(O)c(-c2cccc(-c3cccc(-c4cc(C)cc(OC)c4O)n3)n2)c1",
        "output": "869"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.O.O=C(CCCCCC1(C(=O)O)CCCC1)CCCCCC1(C(=O)O)CCCC1.[BH4-].[Na+].[Na+].[OH-]>>O=C(O)C1(CCCCCC(O)CCCCCC2(C(=O)O)CCCC2)CCCC1",
        "output": "91"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)C[C@@H]1NC[C@H](C2CCCC2)NC1=O.CC(C)C[C@H]1CN(C(=O)/C=C/c2ccccc2)[C@@H](CC(C)C)C(=O)N1.O=C(O)[C@@H]1C[C@H]1c1ccc(Cl)cc1>>CC(C)C[C@H]1C(=O)N[C@@H](C2CCCC2)CN1C(=O)[C@@H]1C[C@H]1c1ccc(Cl)cc1",
        "output": "297"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1oc(-c2ccccc2)nc1CCOc1ccc2c(c1)OCC(C(=O)OC(C)(C)C)C2.O=CO>>Cc1oc(-c2ccccc2)nc1CCOc1ccc2c(c1)OCC(C(=O)O)C2",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "N.N#Cc1cc(C(F)(F)F)cc2c1cnn2C1CCCCO1.[Ni]>>NCc1cc(C(F)(F)F)cc2c1cnn2C1CCCCO1",
        "output": "175"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CO1.C1COCCO1.CCOC(C)=O.O=C(Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)NC1CCCCC1.O=C([O-])[O-].[Cs+].[Cs+]>>O=C(Cc1cc(I)c(Oc2cc(I)c(OCC3CO3)c(I)c2)c(I)c1)NC1CCCCC1",
        "output": "18"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cl.NO.O.O=C([O-])[O-].O=C1CCOc2cc(Cl)c(Cl)cc21.[K+].[K+]>>ON=C1CCOc2cc(Cl)c(Cl)cc21",
        "output": "212"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)Cc1c([N+](=O)[O-])cc([N+](=O)[O-])c2ccccc12.O>>CCOC(=O)Cc1c([N+](=O)[O-])cc(N)c2ccccc12",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC1CCN(CC(=O)O)C1=O.CCN(CC)CC.C[C@H]1CCC[C@@H](C)N1CCN.C[n+]1ccccc1Cl.ClCCl.[I-]>>CC(=O)OC1CCN(CC(=O)NCCN2[C@@H](C)CCC[C@H]2C)C1=O",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)c1ccc([N+](=O)[O-])c(NC(=O)C(F)(F)F)c1.CO.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)c1ccc([N+](=O)[O-])c(N)c1",
        "output": "491"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOc1ccc2c(c1)CN(c1cc(Cl)c3ccccc3n1)CCC2.NCCN>>CCOc1ccc2c(c1)CN(c1cc(NCCN)c3ccccc3n1)CCC2",
        "output": "78"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.Nc1c([N+](=O)[O-])ccc(F)c1F.O.O=C1CCC(=O)N1Br>>Nc1c([N+](=O)[O-])cc(Br)c(F)c1F",
        "output": "4"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)[C@@H](N)Cc1ccccc1.COc1ccc(Br)c(C(=O)O)c1.Cl>>N[C@@H](Cc1ccccc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.O=C(O)Cc1ccc(O)cc1.O=C([O-])O.O=S(=O)(O)O.[Na+]>>CCOC(=O)Cc1ccc(O)cc1",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccncc1.O=C(c1ccccc1)c1cnc2c(C(F)(F)F)cccc2c1-c1cccc(O)c1>>O=C(c1ccccc1)c1cnc2c(C(F)(F)F)cccc2c1-c1cccc(OCc2ccncc2)c1",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CN2CCC(CC2)N1.Cl.Cl.O=C(O)c1cc(-c2ccc3ccccc3c2)[nH]n1>>O=C(c1cc(-c2ccc3ccccc3c2)[nH]n1)N1CCN2CCC1CC2",
        "output": "663"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(Oc1ccc(N2CCC3(CCN(Cc4ccccc4)CC3O)C2=O)cc1)C(F)(F)F.[OH-].[OH-].[Pd+2]>>CC(Oc1ccc(N2CCC3(CCNCC3O)C2=O)cc1)C(F)(F)F",
        "output": "84"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(=O)c1noc2c1CNCC2.Cl.O>>CCOC(=O)c1noc2c1CN(C(=O)OC(C)(C)C)CC2",
        "output": "694"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)C(O)C(Cc1ccccc1)NC(=O)c1cccnc1-c1csc(-c2ccccc2)n1.O>>O=C(NC(Cc1ccccc1)C(O)C(=O)O)c1cccnc1-c1csc(-c2ccccc2)n1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)N1CCNCC1.Cl.Cl.O=C(O)CCC(=NO)c1ccccc1>>CC(C)N1CCN(C(=O)CCC(=NO)c2ccccc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1ccc(S(=O)(=O)C(F)(F)F)cc1Cl.O=C(O)c1ccc(Cl)cc1O>>O=C(Nc1ccc(S(=O)(=O)C(F)(F)F)cc1Cl)c1ccc(Cl)cc1O",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C(Cc1ccc2ccc3cccc4ccc1c2c34)OCCOCCO.O=C(O)c1cc(OCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)c(OCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)c(OCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)c1>>O=C(Cc1ccc2ccc3cccc4ccc1c2c34)OCCOCCOC(=O)c1cc(OCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)c(OCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)c(OCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)c1",
        "output": "33"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(CN2CCSc3cnc(OC)cc3C2)ccc1F.O.[Li+].[OH-]>>COc1cc2c(cn1)SCCN(Cc1ccc(F)c(C(=O)O)c1)C2",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(Oc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-])C(=O)Cl.CCOP(=O)(OCC)C(C)O>>CCOP(=O)(OCC)C(C)OC(=O)C(C)Oc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-]",
        "output": "126"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C1CCOC1.CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(C)=O)CC2)c2ncnn12.C[Mg]Br.[Cl-].[NH4+]>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(C)(C)O)CC2)c2ncnn12",
        "output": "514"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1ccc2ncccc2c1.C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.COc1cc(OC)c(C(C)C)cc1-c1nnc(N)n1-c1ccc2c(ccn2C)c1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>COc1cc(OC)c(C(C)C)cc1-c1nnc(Nc2ccc3ncccc3c2)n1-c1ccc2c(ccn2C)c1",
        "output": "970"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.COc1ccnc(Br)c1.OB(O)c1cccc(F)c1>>COc1ccnc(-c2cccc(F)c2)c1",
        "output": "869"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)/C=C/c1ccc(/C(=C(\\c2ccccc2)C2CCC2)c2ccc3[nH]ncc3c2)cc1.CI.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)/C=C/c1ccc(/C(=C(\\c2ccccc2)C2CCC2)c2ccc3c(cnn3C)c2)cc1",
        "output": "229"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CCN(CC)CCNC(=O)c1c(C)[nH]c(C=O)c1C.CCO.O=C1Cc2cc(S(=O)(=O)Cc3ccccc3)ccc2N1>>CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4ccccc4)cc32)c1C",
        "output": "911"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN.ClCCl.O=C(O)c1cc(S(=O)(=O)Cl)ccc1O>>CNS(=O)(=O)c1ccc(O)c(C(=O)O)c1",
        "output": "43"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCNS(=O)(=O)c1c(Cl)ccc(N)c1O.NC(N)=O.O=C=Nc1ccccc1Cl>>CCCNS(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2ccccc2Cl)c1O",
        "output": "473"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cn1nccc1-c1cccc(N)c1.F[P-](F)(F)(F)(F)F.O=C(O)c1cc2cccc(O)c2oc1=O>>Cn1nccc1-c1cccc(NC(=O)c2cc3cccc(O)c3oc2=O)c1",
        "output": "799"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCOP(=O)(CCCCCC(O)c1ccc(-c2ccc(C)cc2)cc1)OCC.C[Si](C)(C)Cl.[Cl-].[I-].[NH4+].[Na+]>>Cc1ccc(-c2ccc(C(O)CCCCCP(=O)(O)O)cc2)cc1",
        "output": "535"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl.NS(=O)(=O)c1cccc(-c2ccc3c(c2)C(=O)CCC3)n1.O=C(O)CCCCCc1ccccc1>>O=C(CCCCCc1ccccc1)NS(=O)(=O)c1cccc(-c2ccc3c(c2)C(=O)CCC3)n1",
        "output": "801"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(=O)Cn1cc(C=O)c2ccccc21.O.[Na+].[OH-]>>O=Cc1cn(CC(=O)O)c2ccccc12",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)NCC(O)COc1cccc(N)c1C(N)=O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(C)NCC(O)COc1cccc(N)c1CN",
        "output": "215"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCOc1ccc(C(=O)O)cc1.CN(C)C=O.COc1ccc(C(=O)Nc2ccccc2N)cc1.ClCCl.[Cl-]>>CCOc1ccc(C(=O)Nc2ccccc2NC(=O)c2ccc(OC)cc2)cc1",
        "output": "50"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCOC(C)=O.CCc1c(C(=O)OC(C)C)ncc2[nH]c3ccc(NC(C)=O)cc3c12.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCc1c(C(=O)OC(C)C)ncc2[nH]c3ccc(NC(C)=S)cc3c12",
        "output": "695"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CN(C)C=O.COc1cc(F)ccc1C(C)=O.C[S-].[Na+]>>COc1cc(SC)ccc1C(C)=O",
        "output": "503"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CC(=O)Cl.NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2cc(-c3cccc(N)c3)[nH]c12>>C=CC(=O)Nc1cccc(-c2cn3nc(-c4ccc(Oc5ccccc5)cc4)c(C(N)=O)c3[nH]2)c1",
        "output": "10"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)C1CC(S(=O)(=O)c2ccccc2C(F)(F)F)CN1c1cccc(S(C)(=O)=O)c1.[Li+].[OH-]>>CS(=O)(=O)c1cccc(N2CC(S(=O)(=O)c3ccccc3C(F)(F)F)CC2C(=O)O)c1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CNCC(O)CO.COc1cc(C(=O)N2Cc3ccc(C(=O)O)n3Cc3ccccc32)ccc1-c1ccccc1C(F)(F)F.Cl.O.On1nnc2ccccc21>>COc1cc(C(=O)N2Cc3ccc(C(=O)N(C)CC(O)CO)n3Cc3ccccc32)ccc1-c1ccccc1C(F)(F)F",
        "output": "605"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO[C@@H](C)C(=O)O.Cl.N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3OCO4)CC2)CC1>>CO[C@@H](C)C(=O)N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3OCO4)CC2)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.NCC1CCOCC1.O=C=Nc1ccc(C(F)(F)F)cc1>>O=C(NCC1CCOCC1)Nc1ccc(C(F)(F)F)cc1",
        "output": "35"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(c1ccnc(S(C)=O)n1)c1nccc(-c2ccccc2)n1.CS(C)=O.NCCc1ccccc1Cl>>CN(c1ccnc(NCCc2ccccc2Cl)n1)c1nccc(-c2ccccc2)n1",
        "output": "666"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=S([O-])S(=O)[O-].[Na+].[Na+]>>CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cc[n+]([O-])cc2)cc1",
        "output": "262"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.COc1ccc(CN2NC(=O)C3CC3C2=O)cc1.ClCCl.O>>O=C1NN(Cc2ccc(O)cc2)C(=O)C2CC12",
        "output": "207"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl.Nc1cccc(-n2cncn2)c1.O=C(O)c1cccc2c1[nH]c1ccccc12.On1nnc2ccccc21>>O=C(Nc1cccc(-n2cncn2)c1)c1cccc2c1[nH]c1ccccc12",
        "output": "739"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(CC)(OC)c1cccnc1CO.ClCCl.O=[Mn]=O>>CCC(CC)(OC)c1cccnc1C=O",
        "output": "263"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)N.CN(C)C=O.Clc1ncc2cccc(Br)c2n1.O>>CC(C)(C)Nc1ncc2cccc(Br)c2n1",
        "output": "544"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C)=O.Cc1c(O)cccc1Cl.ClCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>Cc1c(Cl)cccc1OCc1ccccc1",
        "output": "49"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)C1CN(C(=O)OC(C)(C)C)C1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC(C)(C)OC(=O)N1CC(CO)C1",
        "output": "343"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)OB(c2ccc(O)c(C=O)c2)OC1(C)C.CCN(CC)CC.COCCOC.COc1ccc(COC(=O)c2ccc3nc(Br)c(N(C)C(C)C)nc3c2)cc1.Cl[Pd]Cl.O.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1ccc(COC(=O)c2ccc3nc(-c4ccc(O)c(C=O)c4)c(N(C)C(C)C)nc3c2)cc1",
        "output": "937"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCN(CC)CC.CCOC(C)=O.Cl.Nc1nc(Cl)ccc1[N+](=O)[O-].O=C([C@@H]1CCCNC1)N1CCCC1.[Cl-].[NH4+]>>Nc1nc(N2CCC[C@@H](C(=O)N3CCCC3)C2)ccc1[N+](=O)[O-]",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)C(=O)Cl.ClCCl.Nc1cc([N+](=O)[O-])ccc1Cl>>CC(C)(C)C(=O)Nc1cc([N+](=O)[O-])ccc1Cl",
        "output": "9"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)c1ccc([N+](=O)[O-])cc1C(=O)N[C@@H]1CC[C@@H](C(F)(F)F)CC1.CO.Cc1ncc(COP(=O)(O)O)c(C=O)c1O.O.[H][H].[Pd]>>CN(C)c1ccc(N)cc1C(=O)N[C@@H]1CC[C@@H](C(F)(F)F)CC1",
        "output": "489"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C(c1cc2cc(O)ccc2[nH]1)N1CCOCC1.OCCCN1CC2CC2C1>>O=C(c1cc2cc(OCCCN3CC4CC4C3)ccc2[nH]1)N1CCOCC1",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CS(C)=O.C[C@@H]1CC[C@@H](Cn2c(N3CCN[C@@H]4CCC[C@H]43)nc3cc(C#N)nc(-c4cncc(Cl)c4)c32)CC1.F[P-](F)(F)(F)(F)F>>CC(=O)N1CCN(c2nc3cc(C#N)nc(-c4cncc(Cl)c4)c3n2C[C@@H]2CC[C@@H](C)CC2)[C@@H]2CCC[C@H]21",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1ccc(N)cc1.F[P-](F)(F)(F)(F)F.O=C(O)Cc1ccc(Cl)nc1>>Cc1ccc(NC(=O)Cc2ccc(Cl)nc2)cc1",
        "output": "365"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)/C=C/c1cccc2c1nn1cc(-c3ccccc3)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)nc21.Cl>>COC(=O)/C=C/c1cccc2c1nn1cc(-c3ccccc3)c(-c3ccc(C4(N)CCC4)cc3)nc21",
        "output": "793"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cc(O)ccn2)CC1.Oc1nc(Cl)nc2cnccc12>>CC(C)(C)OC(=O)N1CCN(c2cc(Oc3nc(O)c4ccncc4n3)ccn2)CC1",
        "output": "542"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1c[nH]c(Sc2ccc(F)cc2)c1.[Na+].[OH-]>>O=C(O)c1c[nH]c(Sc2ccc(F)cc2)c1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CNCCN1.CC(C)(C)[O-].CCOCC.Cc1ccccc1.N#Cc1cccc(Br)c1.[Na+].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>N#Cc1cccc(N2CCNCC2)c1",
        "output": "294"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2c[nH]c3ccc(N4CNc5ncccc54)cc23)CC1.ClCCl>>c1cnc2c(c1)N(c1ccc3[nH]cc(C4CCNCC4)c3c1)CN2",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.Cc1ncccc1CO>>Cc1ncccc1C=O",
        "output": "520"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N1CCNCC1.CCCCCO.Cl.Clc1ccc2nc(-c3ccccc3)c(-c3ccnnc3)n2n1>>CC(C)N1CCN(c2ccc3nc(-c4ccccc4)c(-c4ccnnc4)n3n2)CC1",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COc1ccc(Cn2nc(C)c3c(Oc4ccc([N+](=O)[O-])cn4)ccnc32)cc1.O=C([O-])[O-].[Na+].[Na+]>>COc1ccc(Cn2nc(C)c3c(Oc4ccc(N)cn4)ccnc32)cc1",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CN2CCN1CC2.CC1(C)CC(O)CC(C)(C)N1.ClCCl.O=C(Cl)Oc1ccccc1>>CC1(C)CC(OC(=O)Oc2ccccc2)CC(C)(C)N1",
        "output": "144"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(CCNC(=O)OC(C)(C)C)c(Cl)c1.O=C1CCC(=O)N1Cl>>COc1cc(Cl)c2[nH]c(=O)c3sccc3c2c1-c1ccc(CCNC(=O)OC(C)(C)C)c(Cl)c1",
        "output": "743"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.COC(=O)c1cccc(NC(=O)c2cc([N+](=O)[O-])ccc2Cl)c1.[Na+].[OH-]>>O=C(O)c1cccc(NC(=O)c2cc([N+](=O)[O-])ccc2Cl)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)[C@H]1CC[C@H]2[C@@H]3[C@@H](C)C[C@H]4NC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C.CCOCC.C[Mg]Br.[Cl-].[NH4+]>>C[C@H]1C[C@H]2NC(=O)C=C[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3C(C)(C)O)[C@H]12",
        "output": "514"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCCCCCCCCCCC(CCCCCCCCCCC(=O)O)(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C.ClCCl.O=C1CCC(=O)N1O>>CCCCCCCCCCCC(CCCCCCCCCCC(=O)ON1C(=O)CCC1=O)(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C",
        "output": "303"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCC.CCN(CC)CC.CCOC(C)=O.CS(C)=O.OCCCc1ccccc1Cl.c1cc[nH+]cc1>>O=CCCc1ccccc1Cl",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.O=C1COc2ccc(C(O)CN3CCN(C(=O)OCc4ccccc4)CC3)cc2N1.[Pd]>>O=C1COc2ccc(C(O)CN3CCNCC3)cc2N1",
        "output": "428"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1ccc2c(c1)CCN(c1ccccc1)C2Cc1ccc(Br)cc1.ClCCl.O.O=C([O-])O.[Na+]>>Oc1ccc2c(c1)CCN(c1ccccc1)C2Cc1ccc(Br)cc1",
        "output": "207"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.COC(=O)C1(Nc2cccc([N+](=O)[O-])c2)CCNCC1.Cl.O>>COC(=O)C1(Nc2cccc([N+](=O)[O-])c2)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "694"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CCOC(=O)c1cn(-c2ccc3c(c2)OCC(=O)N3C)c(=O)n(Cc2cccc([N+](=O)[O-])c2C)c1=O.Cl.O>>Cc1c(Cn2c(=O)c(C(=O)O)cn(-c3ccc4c(c3)OCC(=O)N4C)c2=O)cccc1[N+](=O)[O-]",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1CCCC(O)C1.Cl.Fc1ccc(Nc2ncnc3cccc(F)c23)cc1Cl>>CN1CCCC(Oc2cccc3ncnc(Nc4ccc(F)c(Cl)c4)c23)C1",
        "output": "958"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCNC(C(=O)Nc2ccc3ccccc3c2)C1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)c1ccncc1.Cc1cc(Cl)ccc1OCCCC(=O)O.ClCCCl.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(Cl)ccc1OCCCC(=O)N1CCN(C(=O)OC(C)(C)C)CC1C(=O)Nc1ccc2ccccc2c1",
        "output": "297"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(N)c1noc(C)n1.CCCCCCC.CO.Cl.O=C(O)c1ccc(C2CC2)c(OCC2CC2)n1>>CCC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1noc(C)n1",
        "output": "137"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](COCc1ccccc1)C(=O)NCCCCN(CCCNC(=O)OCc1ccccc1)C(=O)OCc1ccccc1.O=C(O)C(F)(F)F>>N[C@@H](COCc1ccccc1)C(=O)NCCCCN(CCCNC(=O)OCc1ccccc1)C(=O)OCc1ccccc1",
        "output": "431"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CCO.Cc1cc([N+](=O)[O-])ccc1OC(F)F.O.[Fe]>>Cc1cc(N)ccc1OC(F)F",
        "output": "202"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O.O=Cc1ccc(OCCCF)c(Cl)c1.[BH4-].[Na+]>>OCc1ccc(OCCCF)c(Cl)c1",
        "output": "356"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=C(C)C(=O)Cl.CCN(CC)CC.Cc1ccccc1.OC1c2ccccc2-c2ccccc21>>C=C(C)C(=O)OC1c2ccccc2-c2ccccc21",
        "output": "320"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.O=P(Cl)(Cl)Cl.O=c1[nH]c(C(F)(F)c2ccc(F)cn2)nc2c(F)cccc12>>Fc1ccc(C(F)(F)c2nc(Cl)c3cccc(F)c3n2)nc1",
        "output": "14"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.COc1ccc(C(=O)Nc2ccc(C3(C(=O)O)CCCC3)cc2)cc1OC.ClCCCl.On1nnc2ccccc21>>COc1ccc(C(=O)Nc2ccc(C3(C(=O)N4CCOCC4)CCCC3)cc2)cc1OC",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.O.O=Cc1cc2c(cc1OS(=O)(=O)C(F)(F)F)CCCC2.[BH4-].[Na+]>>O=S(=O)(Oc1cc2c(cc1CO)CCCC2)C(F)(F)F",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.CC(C)(C)CO[C@H]1CN(C(=O)OC(C)(C)C)[C@@H]([C@@H](O)[C@@H](N)Cc2cc(F)cc(Cl)c2)CO1.CCN(CC)CC.ClCCl>>CC(=O)N[C@@H](Cc1cc(F)cc(Cl)c1)[C@H](O)[C@H]1CO[C@@H](OCC(C)(C)C)CN1C(=O)OC(C)(C)C",
        "output": "339"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc2ncnc(Oc3ccc(N)cc3C)c2cc1OC.ClC(Cl)Cl.O=C=Nc1ccc(F)cc1F>>COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3C)c2cc1OC",
        "output": "912"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Fc1cccc(Br)c1C(F)(F)F.O=C([O-])[O-].OB(O)c1ccncc1.[Cl-].[Cs+].[Cs+].[NH4+]>>Fc1cccc(-c2ccncc2)c1C(F)(F)F",
        "output": "904"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CS(=O)(=O)c1ccc2nc(-c3ccc(B(O)O)cc3)[nH]c2c1.Cc1ccsc1Br>>Cc1ccsc1-c1ccc(-c2nc3ccc(S(C)(=O)=O)cc3[nH]2)cc1",
        "output": "864"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Nc1ncc(Cl)cc1[N+](=O)[O-].[Ni]>>Nc1cc(Cl)cnc1N",
        "output": "269"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)c1ccc(N)cc1.COc1ccc(C(=O)O)cc1S(=O)(=O)N1CCCCC1>>COc1ccc(C(=O)Nc2ccc(C(C)C)cc2)cc1S(=O)(=O)N1CCCCC1",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cccc(C)c1B(O)O.Fc1ccc(OCc2cn3cc(Br)cnc3n2)cc1>>Cc1cccc(C)c1-c1cnc2nc(COc3ccc(F)cc3)cn2c1",
        "output": "871"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.N.O=S(=O)(Nc1cccc(-c2nc(N3CCOCC3)sc2-c2ccnc(Cl)n2)c1F)c1cc(F)ccc1F>>Nc1nccc(-c2sc(N3CCOCC3)nc2-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)n1",
        "output": "312"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.FC(F)(F)c1cc(Br)cnc1Cl>>FC(F)(F)c1cc(Br)cnc1N1CCOCC1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(C)Br.CN(C)C=O.O=C([O-])[O-].O=C1C2=C(CCCC2)C(=O)N1c1cc(O)ccc1F.[I-].[K+].[K+].[K+]>>CC(C)Oc1ccc(F)c(N2C(=O)C3=C(CCCC3)C2=O)c1",
        "output": "153"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COC(=O)c1ccc(C2CCNC2)c(C(F)(F)F)c1.F[P-](F)(F)(F)(F)F.O.O=C(O)c1ccc[nH]1>>COC(=O)c1ccc(C2CCN(C(=O)c3ccc[nH]3)C2)c(C(F)(F)F)c1",
        "output": "605"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(=O)(=O)Cl.OC1CN(C(c2ccccc2)c2ccccc2)C1.c1ccncc1>>CS(=O)(=O)OC1CN(C(c2ccccc2)c2ccccc2)C1",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.Cc1c(CNc2ncc([N+](=O)[O-])c(N3CCc4nc[nH]c4CC3)n2)cccc1-c1cccc(CNC(=O)OC(C)(C)C)c1.Cl.ClCCl>>Cc1c(CNc2ncc([N+](=O)[O-])c(N3CCc4nc[nH]c4CC3)n2)cccc1-c1cccc(CN)c1",
        "output": "793"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCc1cc2cc(OC)ccc2c(OC(C)=O)c1-c1ccccc1.CO.C[O-].N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O.[Na+]>>CCc1cc2cc(OC)ccc2c(O)c1-c1ccccc1",
        "output": "22"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(=O)C1CCC(NC2CC2)CC1.ClCCl.O=C1COC1.[Na+]>>CCOC(=O)C1CCC(N(C2CC2)C2COC2)CC1",
        "output": "983"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cc2cc(Oc3ncnc4cc(O)ccc34)ccc2[nH]1.OCCCN1CCOCC1>>Cc1cc2cc(Oc3ncnc4cc(OCCCN5CCOCC5)ccc34)ccc2[nH]1",
        "output": "478"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O=C(Cl)c1ccc2c(c1)OCO2.O=c1cc(O)c(Cl)c[nH]1.c1ccncc1>>O=C(Oc1cc(=O)[nH]cc1Cl)c1ccc2c(c1)OCO2",
        "output": "482"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCn1cc(C=C2C(=O)Nc3ccccc32)c2ccccc21.CO.Cl.[Li+].[OH-]>>O=C(O)CCn1cc(C=C2C(=O)Nc3ccccc32)c2ccccc21",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Br.CCN(C(C)C)C(C)C.CCN(CC)CCBr.Nc1ccc(-c2cccc3nc(NC(=O)C4CC4)nn23)cc1>>CCN(CC)CCNc1ccc(-c2cccc3nc(NC(=O)C4CC4)nn23)cc1",
        "output": "273"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCc1nn(-c2ccc(C(=O)O)cc2C(F)(F)F)c2c1CCC2.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[B-](F)(F)F.N#Cc1ccc(OCc2ccccc2)c(CN)c1>>CC(C)(C)OC(=O)NCc1nn(-c2ccc(C(=O)NCc3cc(C#N)ccc3OCc3ccccc3)cc2C(F)(F)F)c2c1CCC2",
        "output": "753"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(c1ccccc1[N+](=O)[O-])S(C)(=O)=O.Cl.Cl[Sn]Cl.O.O.[Na+].[OH-]>>CN(c1ccccc1N)S(C)(=O)=O",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCCCC.CCOC(=O)N=NC(=O)OCC.Cc1cc(O)cc(OS(=O)(=O)c2ccccc2S(C)(=O)=O)c1.OCCCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(OCCCO)cc(OS(=O)(=O)c2ccccc2S(C)(=O)=O)c1",
        "output": "478"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(N)CO.CCN(C(C)C)C(C)C.CCOc1ccc2c(c1)n(C1CCCCC1)c(=O)n2S(=O)(=O)c1ccc(C(=O)O)cc1OC.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.ClCCl.F[P-](F)(F)(F)(F)F>>CCOc1ccc2c(c1)n(C1CCCCC1)c(=O)n2S(=O)(=O)c1ccc(C(=O)NC(C)(C)CO)cc1OC",
        "output": "835"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cc1ccc(Sc2ccc([N+](=O)[O-])c(N(C)C(=O)OC(C)(C)C)c2)cc1.[Pd]>>Cc1ccc(Sc2ccc(N)c(N(C)C(=O)OC(C)(C)C)c2)cc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COC(=O)Cc1c(C)nc(Cl)nc1Cl.O=C([O-])[O-].Oc1cccc(-c2ccccc2)c1.[K+].[K+]>>COC(=O)Cc1c(C)nc(Cl)nc1Oc1cccc(-c2ccccc2)c1",
        "output": "668"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1=C(C)C(C)([Rh+]Cl)C(C)=C1C.CCN(CC)CC.CCOC(C)=O.Cc1ccc(S(=O)(=O)N[C@H](c2ccccc2)[C@H](N)c2ccccc2)cc1.Cl.O=C(CCl)c1cccc(Cl)c1.O=CO>>OC(CCl)c1cccc(Cl)c1",
        "output": "24"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NC1CCOCC1.O=C(O)c1cc2c(Nc3ccc4[nH]ncc4c3)ncnc2[nH]1>>O=C(NC1CCOCC1)c1cc2c(Nc3ccc4[nH]ncc4c3)ncnc2[nH]1",
        "output": "137"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.C[O-].Cl.N#Cc1ccccc1N.NO.[Na+]>>NC(=NO)c1ccccc1N",
        "output": "400"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.CCN(CC)CC.CN(CCN1CCNCC1)C(=O)c1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1.ClCCl>>CC(=O)N1CCN(CCN(C)C(=O)c2cccc(C(=O)Nc3ccc(N4CCCCC4)cc3-c3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccn3)c2)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)C(N)Cc1n[nH]c2c(C(F)(F)F)cccc12.[BH4-].[Li+]>>NC(CO)Cc1n[nH]c2c(C(F)(F)F)cccc12",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OCc1ccc2c([N+](=O)[O-])cccc2n1.CC(C)=O.[Ni]>>CC(=O)OCc1ccc2c(N)cccc2n1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=O.CC(=O)O.CN(C)C1(c2cccs2)CCC2(CCNC2)CC1.CO.O=C([O-])O.[BH3-]C#N.[Na+].[Na+]>>CN1CCC2(CCC(c3cccs3)(N(C)C)CC2)C1",
        "output": "217"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.ClCCl.Cn1cc(-c2cc(O)c3ccnn3c2)cn1.O=C1CCC(=O)N1Br>>Cn1cc(-c2cc(O)c3c(Br)cnn3c2)cn1",
        "output": "620"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.O=Cc1ccccc1Br.OCCO>>Brc1ccccc1C1OCCO1",
        "output": "117"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.CCOC(=O)CCc1ccc(OC)cc1F.ClCCl>>CCOC(=O)CCc1ccc(O)cc1F",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCc1ccccc1.O.OCCO.[Na+].[OH-]>>OCCOCc1ccccc1",
        "output": "208"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2sc(NC(=N)N)nc2C)cc1.[Li+].[OH-]>>Cc1nc(NC(=N)N)sc1-c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1=COCCC1.CC1(C)[C@H]2CC=C(CCO)[C@@H]1C2.Cl.Cl.ClCCl.[Na+].[OH-]>>CC1(C)[C@H]2CC=C(CCOC3CCCCO3)[C@@H]1C2",
        "output": "141"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](N)[C@H](n2ccnc2)C1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1[nH]c(C(=O)O)c(Cl)c1Cl.F[P-](F)(F)(F)(F)F>>Cc1[nH]c(C(=O)N[C@H]2CCN(C(=O)OC(C)(C)C)C[C@H]2n2ccnc2)c(Cl)c1Cl",
        "output": "137"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrC(Br)(Br)Br.Cc1ccccc1.O=C(CCCO)c1ccccc1[N+](=O)[O-].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(CCCBr)c1ccccc1[N+](=O)[O-]",
        "output": "378"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)Cc1cccc(Oc2ccc(Br)cc2C=O)c1.NC[C@@H](O)c1ccccc1>>COC(=O)Cc1cccc(Oc2ccc(Br)cc2CNC[C@@H](O)c2ccccc2)c1",
        "output": "468"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNC1.COc1cc(Cl)ncc1[N+](=O)[O-]>>COc1cc(N2CCCC2)ncc1[N+](=O)[O-]",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#CC(O)CCCCCCCC.OCCCCC1OC1c1cccc(Br)n1>>CCCCCCCCC(O)C#Cc1cccc(C2OC2CCCCO)n1",
        "output": "777"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C(Cl)c1cc(F)ccc1C(F)(F)F.O=C(NCCC1CCC1)c1ccc(N2CCNCC2)nn1>>O=C(NCCC1CCC1)c1ccc(N2CCN(C(=O)c3cc(F)ccc3C(F)(F)F)CC2)nn1",
        "output": "201"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.O=[N+]([O-])c1ccc(CCn2cccn2)cc1.[C].[Pd]>>Nc1ccc(CCn2cccn2)cc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)OB(c2ccc3c(c2)CCCO3)OC1(C)C.Cc1nccc2c1[nH]c1ccc(Br)cc12>>Cc1nccc2c1[nH]c1ccc(-c3ccc4c(c3)CCCO4)cc12",
        "output": "933"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "B.C1CCOC1.C1CCOC1.O=C(O)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1>>O=[N+]([O-])c1cc(CO)cc([N+](=O)[O-])c1",
        "output": "72"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=COCCON.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.O=C(O)c1ccc2[nH]ncc2c1Nc1ccc(I)cc1F.On1nnc2ccccc21>>C=COCCONC(=O)c1ccc2[nH]ncc2c1Nc1ccc(I)cc1F",
        "output": "741"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(-c2cccc(N)c2)n2nc(-c3ccncc3)cc2n1.O=C(Cl)c1cccc(C(F)(F)F)c1.c1ccncc1>>Cc1cc(-c2cccc(NC(=O)c3cccc(C(F)(F)F)c3)c2)n2nc(-c3ccncc3)cc2n1",
        "output": "11"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CCOC(C)=O.C[C@@H](O)[C@@H]1CCC(c2cc(F)c(F)c(F)c2)N1C(=O)OC(C)(C)C.Cl>>C[C@@H](O)[C@@H]1CCC(c2cc(F)c(F)c(F)c2)N1",
        "output": "887"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CC(C)CO.CN(C)C=O.O.O=C(O)c1cnc(Cl)c(Cl)c1.[H-].[Na+]>>CC(C)COc1ncc(C(=O)O)cc1Cl",
        "output": "433"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1.O.O=C(O)c1ccc(-c2cc(F)ccc2F)cc1.On1nnc2ccccc21>>O=C(NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1)c1ccc(-c2cc(F)ccc2F)cc1",
        "output": "718"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CNC1CCN(Cc2ccccc2)CC1.Cc1nc(NCC(=O)O)nc(C)c1[N+](=O)[O-]>>Cc1nc(NCC(=O)N(C)C2CCN(Cc3ccccc3)CC2)nc(C)c1[N+](=O)[O-]",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)N.CCN=C=NCCCN(C)C.CN(C)C=O.C[Si](C)(C)CCOCn1cc(C(=O)O)c(-c2nc(-c3ccccc3)cs2)n1.Cl.On1nnc2ccccc21>>CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)nc1-c1nc(-c2ccccc2)cs1",
        "output": "621"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1c[nH]cn1.COC(=O)c1cn(-c2nccc(C)c2F)cn1.CS(C)=O.Cc1ccnc(Br)c1F.O=C([O-])[O-].[Cu]I.[K+].[K+]>>Cc1ccnc(-n2cnc(C(=O)O)c2)c1F",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrP(Br)Br.C1COCCO1.CCOC(C)=O.O.OCc1ccccc1Oc1ccc(Cl)cc1Cl>>Clc1ccc(Oc2ccccc2CBr)c(Cl)c1",
        "output": "300"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)c1ccc(C(=O)Nc2ccc3[nH]nc(-c4ccc(OC)cc4)c3c2)cc1.COC(=O)c1ccc(C(=O)Nc2ccc3c(c2)c(-c2ccc(OC)cc2)nn3C2CCCCO2)cc1.Cl.O=C([O-])O.[Na+]>>COc1ccc(-c2n[nH]c3ccc(NC(=O)c4ccc(C(=O)O)cc4)cc23)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)N.CCO.Nc1nc(Cl)cc(Cl)n1>>CC(C)(C)Nc1cc(Cl)nc(N)n1",
        "output": "166"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCO.Nc1ccccc1C(=O)O.O.O=C([O-])[O-].O=[N+]([O-])c1cc(Cl)ccc1F.[Cu].[K+].[K+].[Na+].[OH-]>>O=C(O)c1ccccc1Nc1ccc(Cl)cc1[N+](=O)[O-]",
        "output": "609"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)CC(=O)O.Cc1ccc(NC(=O)Nc2nc(CN)cs2)c(C(=O)C2CCCC2)c1>>Cc1ccc(NC(=O)Nc2nc(CNC(=O)CN(C)C)cs2)c(C(=O)C2CCCC2)c1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Nc1c(C(=O)O)cccc1C(=O)C(F)(F)F.O=S(Cl)Cl>>Nc1c(C(=O)Cl)cccc1C(=O)C(F)(F)F",
        "output": "3"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)C(c1ccccc1Cl)n1cc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1.[Li+].[OH-]>>O=C(O)C(c1ccccc1Cl)n1cc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.COc1ccc(C)c([N+](=O)[O-])c1.ClC(Cl)(Cl)Cl.O.O=C1CCC(=O)N1Br>>COc1ccc(CBr)c([N+](=O)[O-])c1",
        "output": "29"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CSc1ccc(CBr)cc1.Cc1c(C)c2c(c(C)c1O)C(c1ccc(C(C)C)cc1)C(C)(C)O2>>CSc1ccc(COc2c(C)c(C)c3c(c2C)C(c2ccc(C(C)C)cc2)C(C)(C)O3)cc1",
        "output": "127"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1ccccc1.CCc1ccc(C=O)cc1>>CCc1ccc(C=CC(=O)c2ccccc2)cc1",
        "output": "295"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)O.CCN1CCOCC1.CNC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)CP(=O)(CN)OC.ClCCl>>CNC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)CP(=O)(CNC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)OC",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)C=O.ClCCl.NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(C=CSc3ccncc3)CS[C@H]12.O=C(O)/C(=N\\OC(c1ccccc1)(c1ccccc1)c1ccccc1)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>O=C(NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(C=CSc3ccncc3)CS[C@H]12)C(=NOC(c1ccccc1)(c1ccccc1)c1ccccc1)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1",
        "output": "587"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)/C=C/C(=O)c1nn(-c2cccc(S(C)(=O)=O)c2)ccc1=O.Cc1c(F)cccc1NN>>Cc1c(F)cccc1-n1nccc1-c1nn(-c2cccc(S(C)(=O)=O)c2)ccc1=O",
        "output": "984"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCOC(=O)C(C)c1ccc(N)c(F)c1.Cc1ccc(S(=O)(=O)O)cc1.O.O.O=N[O-].[I-].[Na+]>>CCOC(=O)C(C)c1ccc(I)c(F)c1",
        "output": "200"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.C=CC1(c2ccc(Cl)cc2)CCN(C(=O)OC(C)(C)C)CC1.Cl>>C=CC1(c2ccc(Cl)cc2)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(COc1ccc([N+](=O)[O-])c2ccccc12)c1ccnc(NC(=O)OC(C)(C)C)c1.CCOC(C)=O.CO.[H][H].[Pt]>>CC(COc1ccc(N)c2ccccc12)c1ccnc(NC(=O)OC(C)(C)C)c1",
        "output": "202"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COc1cc(F)c([N+](=O)[O-])cc1OC1CCCC1.[H][H].[Pd]>>COc1cc(F)c(N)cc1OC1CCCC1",
        "output": "202"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.NN.O.O=C1c2ccccc2C(=O)N1CCOc1ccc(Cn2cccn2)cc1>>NCCOc1ccc(Cn2cccn2)cc1",
        "output": "242"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)C1C(c2ccccc2)CCN1C(=O)c1nc2c(C(F)(F)F)cc(-c3ccoc3)cn2c1Cl.[Li+].[OH-]>>O=C(O)C1C(c2ccccc2)CCN1C(=O)c1nc2c(C(F)(F)F)cc(-c3ccoc3)cn2c1Cl",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CNc2ccccc2NC1=O.ClCCl.O.O=C(Cl)c1ccc([N+](=O)[O-])cc1.c1ccncc1>>CC(C)(C)OC(=O)N[C@H]1CN(C(=O)c2ccc([N+](=O)[O-])cc2)c2ccccc2NC1=O",
        "output": "614"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=C(c1ccccc1)c1cccc(N)c1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CS(=O)(=O)Nc1ccc2sc(C(=O)O)cc2c1.F[P-](F)(F)(F)(F)F.Nc1cccc(C2(c3ccccc3)CC2)c1>>CS(=O)(=O)Nc1ccc2sc(C(=O)Nc3cccc(C4(c5ccccc5)CC4)c3)cc2c1",
        "output": "822"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.Cc1ccc(S(=O)(=O)O)cc1.FC(F)(F)Oc1ccccc1C(CCN1CCN(c2cccc3c2OCCO3)CC1)C1OCCO1.O.O>>O=CC(CCN1CCN(c2cccc3c2OCCO3)CC1)c1ccccc1OC(F)(F)F",
        "output": "740"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)N.CC(C)N(C)c1nc2cc(C(=O)O)ccc2nc1-c1ccc2[nH]ncc2c1.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.ClCCl.O>>CC(C)N(C)c1nc2cc(C(=O)NC(C)(C)C)ccc2nc1-c1ccc2[nH]ncc2c1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)NC(CCc1ccc(C(O)CCCCc2ccccc2)cc1)(CO[Si](C)(C)C(C)(C)C)CO[Si](C)(C)C(C)(C)C.CCN(CC)CC.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl>>CC(=O)NC(CCc1ccc(C(=O)CCCCc2ccccc2)cc1)(CO[Si](C)(C)C(C)(C)C)CO[Si](C)(C)C(C)(C)C",
        "output": "32"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CCO.CCOC(=O)c1[nH]c2c(c1CC)C(=O)CC(C)(C)C2.O.[K+].[OH-]>>CCc1c(C(=O)O)[nH]c2c1C(=O)CC(C)(C)C2",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(=O)c1ccc(Oc2cc(F)cc(C3(OC)CCOC3C)c2)cc1.Cl.NO>>CCC(=NO)c1ccc(Oc2cc(F)cc(C3(OC)CCOC3C)c2)cc1",
        "output": "212"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=CCBr.CC(C)=O.Cc1ccc(Nc2ccnc(N)n2)cc1O.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)=CCOc1cc(Nc2ccnc(N)n2)ccc1C",
        "output": "77"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCc1c(O)cccc1[N+](=O)[O-].CC(=O)OC(C)=O.c1ccncc1>>C=CCc1c(OC(C)=O)cccc1[N+](=O)[O-]",
        "output": "46"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC(CO)C1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.[Cl-].[NH4+]>>CC(C)(C)OC(=O)N1CC(COS(C)(=O)=O)C1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCBr.CN(C)C=O.C[C@@H](NC(=O)Cc1ccc(-c2ccccc2)cc1)c1ccc(O)cn1.O=C([O-])[O-].[K+].[K+]>>CCCOc1ccc([C@@H](C)NC(=O)Cc2ccc(-c3ccccc3)cc2)nc1",
        "output": "608"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrP(Br)Br.COCCOC.O.OCc1cc(F)ccc1Br>>Fc1ccc(Br)c(CBr)c1",
        "output": "300"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(CC2CN(Cc3ccccc3)CC2O)n1.CO.[Pd]>>CC(C)(C)OC(=O)Nc1cccc(CC2CNCC2O)n1",
        "output": "84"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "N#Cc1ccc(B(O)O)cc1.O=Cc1cc(Br)ccc1O>>N#Cc1ccc(-c2ccc(O)c(C=O)c2)cc1",
        "output": "837"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)CCCN.Cc1ccc(Cl)c([N+](=O)[O-])c1.Cc1ccccc1>>Cc1ccc(NCCCN(C)C)c([N+](=O)[O-])c1",
        "output": "304"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C.CC(C)C(=O)Cl.CCN(CC)CC.CN(C)C=O.CO.Cl.NC1c2ccccc2-c2[nH]c(=O)c3nccn3c21>>CC(C)C(=O)NC1c2ccccc2-c2[nH]c(=O)c3nccn3c21",
        "output": "206"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(=O)(=O)c1cccc(S(=O)(=O)n2cc(CO)cc2Br)c1.O=S(=O)=O>>CS(=O)(=O)c1cccc(S(=O)(=O)n2cc(C=O)cc2Br)c1",
        "output": "520"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cccc(NC(=O)[C@@H](N)C(C)C)c1C(=O)O.O=C(O)CNC(=O)C1c2ccccc2-c2ccccc21>>Cc1cccc(NC(=O)[C@@H](NC(=O)CNC(=O)C2c3ccccc3-c3ccccc32)C(C)C)c1C(=O)O",
        "output": "133"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCc1ccccc1-c1ccc(CO[Si](C)(C)C(C)(C)C)cc1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.[F-]>>CC(C)(C)OC(=O)NCc1ccccc1-c1ccc(CO)cc1",
        "output": "708"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)C=O.COc1ccc2ccc(C#N)cc2c1OS(=O)(=O)C(F)(F)F.OB(O)c1ccccc1.[Cl-].[NH4+]>>COc1ccc2ccc(C#N)cc2c1-c1ccccc1",
        "output": "825"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.NC[C@@H]1CCN(c2nc(-c3ccc(N4CCOCC4)cc3)cc3nccnc23)C1>>CS(=O)(=O)NC[C@@H]1CCN(c2nc(-c3ccc(N4CCOCC4)cc3)cc3nccnc23)C1",
        "output": "493"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)CN(Cc1cc(F)cc(F)c1)C(=O)OC(C)(C)C.C[Si](C)(C)[O-].[K+]>>CC(C)(C)OC(=O)N(CC(=O)O)Cc1cc(F)cc(F)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1ccc(Nc2nccc(-c3cccnc3)n2)cc1.CCOC(=O)c1ccc(Nc2nccc(Nc3nccs3)n2)cc1>>O=C(O)c1ccc(Nc2nccc(Nc3nccs3)n2)cc1",
        "output": "5"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1ccc(-c2c(F)cccc2F)nc1.CO.[Na+].[OH-]>>O=C(O)c1ccc(-c2c(F)cccc2F)nc1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.NC1CCOCC1.Nc1nc(Cl)cc(Cl)n1>>Nc1nc(Cl)cc(NC2CCOCC2)n1",
        "output": "166"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C(C)(C)Br.Oc1ccc2c(c1)c(-c1ccncc1)c1n2CCCC1>>CCOC(=O)C(C)(C)Oc1ccc2c(c1)c(-c1ccncc1)c1n2CCCC1",
        "output": "305"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.CCc1cccc(N)c1>>CCc1cccc(NC(C)=O)c1",
        "output": "6"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NCCCCCC(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCN1CCNCC1)c1nnc(C)n1-2.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+]>>Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCN1CCN(C(=O)CCCCCNC(=O)OC(C)(C)C)CC1)c1nnc(C)n1-2",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.Cc1cc(=O)n(C2CCCC2)c2nc(Cl)ncc12.O.O=C(O)C(=O)O.O=C1CCC(=O)N1Br.O=S([O-])O.[Na+]>>Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Cl)ncc12",
        "output": "518"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1cccc(SCc2ccccc2)n1.CCN.O>>CCNc1cccc(SCc2ccccc2)n1",
        "output": "715"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CNC1CCCN(C2c3ccccc3Oc3ccccc32)C1.ClC(Cl)Cl>>CC(=O)N(C)C1CCCN(C2c3ccccc3Oc3ccccc32)C1",
        "output": "369"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)Nc1cncc(C#Cc2cc([N+](=O)[O-])ccc2NC(=O)OC(C)(C)C)c1.CO.O.[Fe]>>CC(C)(C)OC(=O)Nc1cncc(C#Cc2cc(N)ccc2NC(=O)OC(C)(C)C)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC[C@H]1COc1cccc2[nH]ccc12.O=S(=O)(Cl)c1ccccc1.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCC[C@H]1COc1cccc2c1ccn2S(=O)(=O)c1ccccc1",
        "output": "648"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.C[C@@H](N)Cn1cccn1.Cn1nc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)c2ccc(F)cc21.F[B-](F)(F)F.O.O=C(O)C(F)(F)F>>C[C@H](Cn1cccn1)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(F)ccc34)nc12",
        "output": "737"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.COC(=O)c1ccc2c(c1)CCC1C2=NN(c2ccc(C#N)c(OCc3ccccc3)c2)C1C1CCCC1.[H][H].[Pd]>>COC(=O)c1ccc2c(c1)CCC1C2=NN(c2ccc(C#N)c(O)c2)C1C1CCCC1",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ccc(Oc2ccc(Cl)c(OC(F)(F)F)c2)cc1.[Br-].[Li]CCCC>>C=Cc1ccc(Oc2ccc(Cl)c(OC(F)(F)F)c2)cc1",
        "output": "649"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(C)=O.O=C([O-])[O-].O=C1/C(=C/c2ccc(O)cc2)Oc2ccc(I)cc21.OCCCl.[K+].[K+]>>O=C1/C(=C/c2ccc(OCCO)cc2)Oc2ccc(I)cc21",
        "output": "74"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1ccc2c(Nc3cc(C(=O)Cl)ccc3Oc3ccc(OCc4ccccc4)cc3)ncnc2n1.Nc1cccc(F)c1>>CC(C)c1ccc2c(Nc3cc(C(=O)Nc4cccc(F)c4)ccc3Oc3ccc(OCc4ccccc4)cc3)ncnc2n1",
        "output": "11"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN(C)C=O.Cc1ccc([N+](=O)[O-])cc1CC(=O)O.Clc1cccc2c(C3CCNCC3)c[nH]c12.O=C(n1ccnc1)n1ccnc1>>Cc1ccc([N+](=O)[O-])cc1CC(=O)N1CCC(c2c[nH]c3c(Cl)cccc23)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C1Cc2ccc(Br)c3cccc1c23.[BH4-].[Cl-].[NH4+].[Na+]>>OC1Cc2ccc(Br)c3cccc1c23",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Nc1cc(Cl)c(-c2cnccn2)cc1/C=C/C(=O)O.Fc1ccc(CN2CC3COCC(C2)N3)cc1>>CC(=O)Nc1cc(Cl)c(-c2cnccn2)cc1/C=C/C(=O)N1C2COCC1CN(Cc1ccc(F)cc1)C2",
        "output": "811"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)N(C)C.CC1=C(C(=O)O)C(c2ccccc2)NC(=S)N1.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.COc1ccc(CO)cc1>>COc1ccc(COC(=O)C2=C(C)NC(=S)NC2c2ccccc2)cc1",
        "output": "174"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(=O)Cl.CCN(CC)CC.Cl.ClCCl.Cn1cc(Br)cc(Nc2cccc(OCCN)n2)c1=O>>CCC(=O)NCCOc1cccc(Nc2cc(Br)cn(C)c2=O)n1",
        "output": "45"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)CC(O[Si](C)(C)C(C)(C)C)[C@@H](NC(=O)OCc1ccccc1)C(C)C.CCOC(C)=O.[BH4-].[Ca+2].[Cl-].[Cl-].[Na+]>>CC(C)[C@H](NC(=O)OCc1ccccc1)C(CCO)O[Si](C)(C)C(C)(C)C",
        "output": "225"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNC1.CCS(=O)(=O)c1ccc(-c2nc(-c3nc4cc(OC)cc(OC)c4c(=O)[nH]3)ccc2OCCBr)cc1.CS(C)=O.O>>CCS(=O)(=O)c1ccc(-c2nc(-c3nc4cc(OC)cc(OC)c4c(=O)[nH]3)ccc2OCCN2CCCC2)cc1",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.COC(=O)CNC(=O)c1n[nH]c2ccc(Nc3ccnc(N)n3)cc12.Cl.[Na+].[OH-]>>Nc1nccc(Nc2ccc3[nH]nc(C(=O)NCC(=O)O)c3c2)n1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CC[C@H](C)NS(=O)(=O)c1ccc(C)cc1.C[Si](C)(C)C#CC[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1>>C#CC[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1",
        "output": "337"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[N-]=[N+]=NCC1CCC(COc2ccccc2)OC1>>NCC1CCC(COc2ccccc2)OC1",
        "output": "89"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1cn(CCCCc2cc3c(F)c(C4CC4)[nH]c3nn2)nn1.O.[Li+].[OH-]>>O=C(O)c1cn(CCCCc2cc3c(F)c(C4CC4)[nH]c3nn2)nn1",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOP(=O)(OCC)C(F)(F)CCO.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>CCOP(=O)(OCC)C(F)(F)CCOS(=O)(=O)c1ccc(C)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].COc1cccc([N+](=O)[O-])c1N.[Na+]>>COc1cc(Br)cc([N+](=O)[O-])c1N",
        "output": "98"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(F)CN1CCC(COc2ccc(-c3ccc(C(=O)O)cc3)cc2)CC1.CCN(C(C)C)C(C)C.CN(C)C=O.ClCCCl.On1nnc2ccccc21.[Cl-].[NH4+]>>CC(C)(F)CN1CCC(COc2ccc(-c3ccc(C(N)=O)cc3)cc2)CC1",
        "output": "358"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC(CN2CCCCC2)C1.ClCCl.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F>>C1CCN(CC2CNC2)CC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCCBr.CC(C)=O.O=C([O-])[O-].OCCc1ccc(O)cc1.[K+].[K+]>>OCCc1ccc(OCCBr)cc1",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)/N=N/C(=O)OCC.ClCCl.OCCN1CCOCC1.Oc1ccc(-c2n[nH]c3c2Cc2ccccc2-3)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>c1ccc2c(c1)Cc1c(-c3ccc(OCCN4CCOCC4)cc3)n[nH]c1-2",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)/N=N/C(=O)OCC.CCOC(C)=O.CCc1cc(C)c2c(c1)[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1N(CCO)C2=O.Cc1ccccc1.Oc1cccnc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCc1cc(C)c2c(c1)[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1N(CCOc1cccnc1)C2=O",
        "output": "547"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCN(CCCOS(C)(=O)=O)Cc1c2ccccc2cc2ccccc12.NCCCO>>CCN(CCCNCCCO)Cc1c2ccccc2cc2ccccc12",
        "output": "559"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.CN1CCNCC1.O.O=S(=O)(c1ccccc1)n1cc(-c2ccc3nc(CCl)[nH]c3c2)c2ccc(F)cc21>>CN1CCN(Cc2nc3ccc(-c4cn(S(=O)(=O)c5ccccc5)c5cc(F)ccc45)cc3[nH]2)CC1",
        "output": "257"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)c1ccc(N2CCNCC2)c(F)c1.CC(C)Sc1ccc(S(C)(=O)=O)cc1C(=O)O>>CC(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3SC(C)C)CC2)c(F)c1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C1COCCN1.CC(C)(C)[O-].Clc1cc(Cl)cc(I)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Clc1cc(Cl)cc(N2CCOCC2)c1",
        "output": "931"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.Cc1cc(C)cc(Sc2ccc3nc(CCl)n(C)c3n2)c1.O=S(=O)(O)O.O=[N+]([O-])O>>Cc1cc(Sc2ccc3nc(CCl)n(C)c3n2)cc(C)c1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)c1ccc(CC(=O)O)cc1.Nn1nc(C(F)(F)F)c2ccccc2c1=O>>CN(C)c1ccc(CC(=O)Nn2nc(C(F)(F)F)c3ccccc3c2=O)cc1",
        "output": "459"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCOCC.COC(=O)c1ccc(CN(C2CCCCC2F)S(=O)(=O)c2ccc(Cl)cc2)cc1.Cl.O.[Li+].[OH-]>>O=C(O)c1ccc(CN(C2CCCCC2F)S(=O)(=O)c2ccc(Cl)cc2)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.C[Si](C)(C)C#Cc1cc(Cl)cc(Cl)c1.[K+].[OH-]>>C#Cc1cc(Cl)cc(Cl)c1",
        "output": "337"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)CC1(C(CCN2C(=O)c3ccccc3C2=O)C(=O)NOCc2ccccc2)CCN(CCc2ccccc2)C1=O.[OH-].[OH-].[Pd+2].[Pd]>>CC(C)CC1(C(CCN2C(=O)c3ccccc3C2=O)C(=O)NO)CCN(CCc2ccccc2)C1=O",
        "output": "707"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNCCN(C)C.ClCCl.F[P-](F)(F)(F)(F)F.N#Cc1ccc(N2N=C3c4ccc(C(=O)O)nc4CCC3C2C2CCCC2)cc1Cl.O>>CN(C)CCN(C)C(=O)c1ccc2c(n1)CCC1C2=NN(c2ccc(C#N)c(Cl)c2)C1C1CCCC1",
        "output": "605"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.C[Si](C)(C)C#Cc1ccc(-c2cnco2)cc1.O=C([O-])[O-].[K+].[K+]>>C#Cc1ccc(-c2cnco2)cc1",
        "output": "337"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1NCCn2c(-c3ccc(F)nc3)nnc21.O=C(O)c1cc2ncc(Br)cn2n1>>CC1c2nnc(-c3ccc(F)nc3)n2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "663"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C1CCc2[nH]c3ccc(N)cc3c2C1.CS(=O)(=O)c1ccc(C(=O)O)cc1>>CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(S(C)(=O)=O)cc4)cc3c2C1",
        "output": "50"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.N#Cc1ccc(Br)cc1F.[C-]#N.[C-]#N.[Pd].[Zn+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1ccc(C#N)c(F)c1",
        "output": "65"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.NCCC(O)(c1ccccc1)c1ccccc1.O=C(Cl)c1ccccc1.c1ccncc1>>O=C(NCCC(O)(c1ccccc1)c1ccccc1)c1ccccc1",
        "output": "271"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccccc1Oc1ccc(Cl)cc1Cl>>Nc1ccccc1Oc1ccc(Cl)cc1Cl",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Br.Br.C1COCCO1.CC(=O)OC(C)=O.O=C([O-])[O-].Oc1ccc(N2CCNCC2)cc1.[K+].[K+]>>CC(=O)N1CCN(c2ccc(O)cc2)CC1",
        "output": "369"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CI.CN(C)C=O.O=C([O-])[O-].O=c1cc(Br)c2cc(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)ccc2[nH]1.[K+].[K+]>>Cn1c(=O)cc(Br)c2cc(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)ccc21",
        "output": "191"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C[C@H]1CCCN1CCCO.O=[N+]([O-])c1ccc(O)cc1>>C[C@H]1CCCN1CCCOc1ccc([N+](=O)[O-])cc1",
        "output": "478"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc(O)nc2ccccc12.O=[N+]([O-])O.[Na+].[OH-]>>Cc1cc(O)nc2ccc([N+](=O)[O-])cc12",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=Cc1ccc(F)cc1.N#Cc1ccnc(-n2nccc2OCc2ccc(Cl)cc2/C=C/c2ccc(F)cc2)c1.OCc1ccc(Cl)cc1Br>>OCc1ccc(Cl)cc1/C=C/c1ccc(F)cc1",
        "output": "539"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1CC[C@@H](c2cccc3[nH]cnc23)[C@H](c2ccc(Br)cc2Cl)C1.CC(C)O.CCOC(C)=O.COCCCc1ccccc1B(O)O.O=C([O-])[O-].[Na+].[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COCCCc1ccccc1-c1ccc([C@@H]2CN(C(=O)OC(C)(C)C)CC[C@H]2c2cccc3[nH]cnc23)c(Cl)c1",
        "output": "837"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCn1c2c(c3cc(C(=O)N4CCC(C)CC4)ccc31)CN(C1CCN(C(=O)OC(C)(C)C)CC1)CC2.ClCCl.O=C(O)C(F)(F)F>>C=CCn1c2c(c3cc(C(=O)N4CCC(C)CC4)ccc31)CN(C1CCNCC1)CC2",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CNC.C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CC2CO2)(c2ccc(F)cc2)OC1=O>>C[C@@H](c1ccc(-c2ccc(F)cc2F)cc1)N1CC[C@](CC(O)CN(C)C)(c2ccc(F)cc2)OC1=O",
        "output": "76"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC(C=NN1CC(=O)NC1=O)Cc1ccccc1.Cl>>NC(C=NN1CC(=O)NC1=O)Cc1ccccc1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCCC(CCN2C(=O)C3(COc4cc5c(cc43)OCO5)c3ccccc32)C1.ClCCl.O=C(O)C(F)(F)F>>O=C1N(CCC2CCCNC2)c2ccccc2C12COc1cc3c(cc12)OCO3",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(Cc1cccc(C#C[Si](C)(C)C)c1)C1CC1.CO.O=C([O-])[O-].[K+].[K+]>>C#Cc1cccc(CN(C)C2CC2)c1",
        "output": "337"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(O)Cn1ccc(N)n1.CC(C)S(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)O)cc1.CN(C)C=O.Cc1cccc(C)n1.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)S(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2ccn(CC(C)(C)O)n2)cc1",
        "output": "795"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CI.CN(C)C=O.C[Si](C)(C)[N-][Si](C)(C)C.O=[N+]([O-])c1ccc2c(Br)c[nH]c2c1.[Li+]>>Cn1cc(Br)c2ccc([N+](=O)[O-])cc21",
        "output": "191"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(=O)Oc1cc(C=O)c2ccccc2c1.CC[SiH](CC)CC.COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.O=C(O)C(F)(F)F>>COc1cc(O)c2c(c1C(=O)NCc1cc(OC(C)=O)cc3ccccc13)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C",
        "output": "996"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)Cl.COC(=O)C1(NC(=O)c2cc3ccccc3cc2NC(=O)Nc2c(C)cc(C)cc2C)CCNCC1.ClCCl>>CCOC(=O)N1CCC(NC(=O)c2cc3ccccc3cc2NC(=O)Nc2c(C)cc(C)cc2C)(C(=O)OC)CC1",
        "output": "219"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1ccc(-c2ccc(OCCCCBr)cc2)cc1.C[O-].Cl.O.O=S(=O)(O)O.[Na+]>>COCCCCOc1ccc(-c2ccc(C(=O)OC)cc2)cc1",
        "output": "95"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1cc(=O)c2c(C)cc(I)cc2[nH]1.CCOC(=O)c1cc(=O)c2c(I)cc(C)cc2[nH]1.[Na+].[OH-]>>Cc1cc(I)c2c(=O)cc(C(=O)O)[nH]c2c1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)c1cc2cc(OC(=O)c3ccccc3)cnc2n1C(=O)OC(C)(C)C.COC(=O)c1cc2c(nc1COCC1CC1)N1[C@H](C)CN(C(=O)OC(C)(C)C)C[C@H]1C2.[H-]>>C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3cc(CO)c(COCC4CC4)nc3N12",
        "output": "522"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.ClCCCBr.O=C([O-])[O-].OCCc1ccc(O)cc1.[K+].[K+]>>OCCc1ccc(OCCCCl)cc1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[C@@H](O[C@H]1CCc2ncccc2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.[Na+].[OH-]>>C[C@@H](O[C@H]1CCc2c(ccc[n+]2[O-])[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "262"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccc(N)cc1.CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.CCN(C(C)C)C(C)C.CCOC(=O)C(C#N)=NOC(N(C)C)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F>>CC(=O)c1ccc(NC(=O)C2CCN(C(=O)OC(C)(C)C)CC2)cc1",
        "output": "365"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)CC1.CN(C)C=O.Cn1c(Cl)nc2ccccc21.O.[H-].[Na+]>>Cn1c(OC2CCN(C(=O)OC(C)(C)C)CC2)nc2ccccc21",
        "output": "37"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(C)(O)C#Cc1ccc(C(CC2CCCC2)C(=O)O)cc1.CCN(CC)CC.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.ClCCl.F[P-](F)(F)(F)(F)F.Nc1nccs1>>CCC(C)(O)C#Cc1ccc(C(CC2CCCC2)C(=O)Nc2nccs2)cc1",
        "output": "681"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.Fc1ccc([C@H]2CNCCN2Cc2cncc(Br)c2)cc1.[Na+]>>CN1CCN(Cc2cncc(Br)c2)[C@@H](c2ccc(F)cc2)C1",
        "output": "217"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)[O-].CC(C)C[AlH]CC(C)C.COC(=O)c1ccc2ncn(-c3ccccc3)c2c1.[Na+]>>OCc1ccc2ncn(-c3ccccc3)c2c1",
        "output": "444"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCCBr.CCO.Oc1ccc2nonc2c1.[Na+].[OH-]>>BrCCOc1ccc2nonc2c1",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cc2ccccn2c1-c1ccn(CCCl)n1.O=C([O-])[O-].OCCNCCO.[K+].[K+]>>CCOC(=O)c1cc2ccccn2c1-c1ccn(CCN(CCO)CCO)n1",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CSCCN1C(C)c2cc(Br)ccc2S1(=O)=O.ClCCl.O=C(OO)c1cccc(Cl)c1>>CC1c2cc(Br)ccc2S(=O)(=O)N1CCS(C)=O",
        "output": "13"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(C)(C)OC(=O)NC1CCNC1.CCN(CC)CC.CCOC(=O)c1cc(F)c(F)c(Cl)c1F.CCOC(C)=O>>CCOC(=O)c1cc(F)c(N2CCC(NC(=O)OC(C)(C)C)C2)c(Cl)c1F",
        "output": "773"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NC1CCC(N)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.Cn1nc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)c2ccc(Cl)cc21.F[P-](F)(F)(F)(F)F.O>>Cn1nc(-c2cnc3c(n2)c(C(=O)NC2CCC(NC(=O)OC(C)(C)C)C2)cn3COCC[Si](C)(C)C)c2ccc(Cl)cc21",
        "output": "737"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CN(CCc1ccc([N+](=O)[O-])cc1)Cc1nc2cc([N+](=O)[O-])ccc2o1.[Ni]>>CN(CCc1ccc(N)cc1)Cc1nc2cc(N)ccc2o1",
        "output": "204"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCCN.CCCCO.CCN(C(C)C)C(C)C.COc1ccc(N(C)c2nc(Cl)nc3ccc(OC)cc23)cc1.COc1ccc(N(C)c2nc(NCCNC(=O)OC(C)(C)C)nc3ccc(OC)cc23)cc1>>COc1ccc(N(C)c2nc(NCCN)nc3ccc(OC)cc23)cc1",
        "output": "538"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CNC.Fc1ccccc1Cn1cnc2cnc(Cl)nc21>>CN(C)c1ncc2ncn(Cc3ccccc3F)c2n1",
        "output": "214"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(-c2nc3cc(Br)ccc3o2)cc1[N+](=O)[O-].N#Cc1cccc(B(O)O)c1>>COc1ccc(-c2nc3cc(-c4cccc(C#N)c4)ccc3o2)cc1[N+](=O)[O-]",
        "output": "909"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCOCC.Cl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.OCC(F)(F)C(F)(F)C(F)(F)F>>O=S(=O)(OCC(F)(F)C(F)(F)C(F)(F)F)C(F)(F)F",
        "output": "582"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(C3CCCCC3)c(Br)n(CC(=O)N3CCOCC3)c2c1.[Li+].[OH-]>>O=C(O)c1ccc2c(C3CCCCC3)c(Br)n(CC(=O)N3CCOCC3)c2c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CNCc1cc2ccccc2[nH]1.ClCCCl.Nc1ccc(C=CC(=O)O)cn1.O.On1nnc2ccccc21>>CN(Cc1cc2ccccc2[nH]1)C(=O)/C=C/c1ccc(N)nc1",
        "output": "517"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOCC.N#CCCCN1CCOCC1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCCCCN1CCOCC1",
        "output": "246"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CI.CN(C)C=O.Oc1ccc2c(c1)OCO2.[H-].[Na+]>>COc1ccc2c(c1)OCO2",
        "output": "62"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.Cc1c(-c2ccccn2)nc2cc(F)ccc2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21.O=C1CCC(=O)N1Br>>Cc1c(-c2ccccn2)nc2cc(F)ccc2c1N1CC(C)(C)c2nc(Br)c(N3CCOCC3)cc21",
        "output": "779"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#C[C@]1(O)CCN(C)C1=O.COC(=O)c1nn(-c2cc(Br)cc(CC#N)c2)c2ncccc12>>COC(=O)c1nn(-c2cc(C#C[C@]3(O)CCN(C)C3=O)cc(CC#N)c2)c2ncccc12",
        "output": "659"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1CN(C(=O)Cc2ccccc2)CC(C)N1.O=C(NCC(F)(F)F)C1(CCCCBr)c2ccccc2-c2ccccc21>>CC1CN(C(=O)Cc2ccccc2)CC(C)N1CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCC(S)CN.CCN(C(C)C)C(C)C.C[Si](C)(C)Cl.O=C(Cl)OCc1ccc([N+](=O)[O-])cc1>>CCC(S)CNC(=O)OCc1ccc([N+](=O)[O-])cc1",
        "output": "479"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccccc1Oc1c(Cl)nc(N2CCN(C(C)C)CC2)nc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1.OCCCO>>COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCN(C(C)C)CC2)nc1OCCCO",
        "output": "653"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC(C)(C)c1ccc(S(=O)(=O)Cl)cc1.Nc1ccc(Cl)cc1C(=O)c1ccccc1>>CCC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccccc2)cc1",
        "output": "68"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.CN(C)CCCl.Cl.Nc1cc(Cl)ccc1O.O=C([O-])[O-].[K+].[K+]>>CN(C)CCOc1ccc(Cl)cc1N",
        "output": "74"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.C=CC(=O)N[C@H]1CC[C@@H](Nc2nc(Cl)nc3ccsc23)CC1.Cn1cc(N)cn1.O=C(O)C(F)(F)F.[Na+].[OH-]>>C=CC(=O)N[C@H]1CC[C@@H](Nc2nc(Nc3cnn(C)c3)nc3ccsc23)CC1",
        "output": "992"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)CN1CCN(C2(c3ccccc3)C(=O)Nc3ccc(-c4c(C)noc4C)cc32)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)(N1CCN(CCO)CC1)C(=O)N2",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CCO)C(=O)OC(C)(C)C.CCOC(C)=O.ClCCl.c1ccncc1>>CC(C)(C)OC(=O)N[C@@H](CC=O)C(=O)OC(C)(C)C",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.CC(C)(C)C(=O)c1ccc(CBr)cc1.Oc1ccccc1.[H-].[Na+]>>CC(C)(C)C(=O)c1ccc(COc2ccccc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=CC(=O)Cl.CCN(CC)CC.CN(C)C=O.Cc1cccc(Nc2c(C#N)cnc3ccc(N)cc23)c1.O=C([O-])O.[Na+]>>C=CC(=O)Nc1ccc2ncc(C#N)c(Nc3cccc(C)c3)c2c1",
        "output": "10"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CC#N.CCN(CC)CC.COC(=O)C1CNCCN1C(=O)OC(C)(C)C>>COC(=O)C1CN(Cc2ccccc2)CCN1C(=O)OC(C)(C)C",
        "output": "248"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.Cc1nnc([C@H]2CCCN2)n1Cc1ccc(Cl)cc1.Cl.ClCCl.O=C=Nc1ccc(Cl)cc1>>Cc1nnc([C@H]2CCCN2C(=O)Nc2ccc(Cl)cc2)n1Cc1ccc(Cl)cc1",
        "output": "323"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(NCCCCO)OCc1ccccc1>>O=CCCCNC(=O)OCc1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.Cl.O.[N-]=[N+]=NCC1CN(c2ccc3cc(-c4ccccc4C(F)(F)F)[nH]c(=O)c3c2)C(=O)O1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NCC1CN(c2ccc3cc(-c4ccccc4C(F)(F)F)[nH]c(=O)c3c2)C(=O)O1",
        "output": "89"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)c1ccc(-c2cnc(C)o2)c(OC)c1.Cl.[Na+].[OH-]>>COc1cc(C(=O)O)ccc1-c1cnc(C)o1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC=O.COCCCOc1cc(CC(N)C2(C)CC2)ccc1OC.O=CO>>COCCCOc1cc(CC(NC=O)C2(C)CC2)ccc1OC",
        "output": "370"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)C1Cc2ccccc2N1C(=O)OCc1ccccc1.[BH4-].[Li+]>>O=C(OCc1ccccc1)N1c2ccccc2CC1CO",
        "output": "430"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H](N)[C@@H]1c1ccccc1.CC(C)(C)OC(=O)N1CCC[C@H](NCc2cc(C(C)(F)F)ccc2OC(F)(F)F)[C@@H]1c1ccccc1.COc1ccc(C(C)(C)C(F)(F)F)cc1C=O>>COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN(C(=O)OC(C)(C)C)[C@H]1c1ccccc1",
        "output": "468"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)c1ccncc1.COC(=O)Cc1ccc(O)c(OC)c1.ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>COC(=O)Cc1ccc(OS(=O)(=O)C(F)(F)F)c(OC)c1",
        "output": "731"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(=O)OCc1cc(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c(N2C[C@@H](C)O[C@@H](C)C2)c(F)c1F.Cl.O>>CC(=O)OCc1cc(CO)c(N2C[C@@H](C)O[C@@H](C)C2)c(F)c1F",
        "output": "781"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCc1ncc(CO)n1Cc1ccccc1Cl.ClCCl>>CCCCc1ncc(C=O)n1Cc1ccccc1Cl",
        "output": "287"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)c1cc(C(=O)N2CCCC(c3ccccc3F)C2)ccn1.CNc1cc(C(=O)O)ccn1.Cc1ccc(C2CCCNC2)cc1.Cl>>CNc1cc(C(=O)N2CCCC(c3ccc(C)cc3)C2)ccn1",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.COC(=O)CCC(=O)Cl.ClCCl.Nc1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)c(F)c1>>COC(=O)CCC(=O)Nc1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)c(F)c1",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(=O)[O-].CC(=O)[O-].CCCCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCO.CCOC(C)=O.O.O=C([O-])[O-].O=C1CCCc2cc(OS(=O)(=O)C(F)(F)F)ccc21.OB(O)c1cccc(OCc2ccccc2)c1.[Br-].[K+].[K+].[Pd+2]>>O=C1CCCc2cc(-c3cccc(OCc4ccccc4)c3)ccc21",
        "output": "825"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=Cc1cc(C(=O)O)c(F)cc1Oc1cnc(OC(C)C)c(Cl)c1.CN(C)S(N)(=O)=O.NS(=O)(=O)N1CCC1.O=C(O)c1cc(Cl)c(Oc2ccc(Cl)c(C(F)(F)F)c2)cc1F>>C=Cc1cc(C(=O)NS(=O)(=O)N2CCC2)c(F)cc1Oc1cnc(OC(C)C)c(Cl)c1",
        "output": "886"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.ClCCl.F[P-](F)(F)(F)(F)F.NCc1nccnc1Cl.O=C(O)[C@@H]1CC[C@@H]2CCCC(=O)N2C1>>O=C(NCc1nccnc1Cl)[C@@H]1CC[C@@H]2CCCC(=O)N2C1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1cc(C)c([N+](=O)[O-])cc1F.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>Cc1cc(CBr)c(F)cc1[N+](=O)[O-]",
        "output": "29"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(Cl)OC(=O)Cl.CN1CCOCC1.Cl.ClCCl.NCC1(CC(=O)OCc2ccccc2)CCCCC1>>CC(Cl)OC(=O)NCC1(CC(=O)OCc2ccccc2)CCCCC1",
        "output": "94"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(O)(c1ccc(OCc2ccccc2)cc1)c1cccc(C(F)(F)F)c1.CO.[H][H].[Pd]>>CCC(O)(c1ccc(O)cc1)c1cccc(C(F)(F)F)c1",
        "output": "23"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCCCC.CCO.CCOC(C)=O.CCOC(C)=O.O.O=C(Nc1cc(Oc2ccc([N+](=O)[O-])cc2F)ccn1)N1CCCC1.[Cl-].[Fe].[NH4+]>>Nc1ccc(Oc2ccnc(NC(=O)N3CCCC3)c2)c(F)c1",
        "output": "335"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(=O)O.O=[N+]([O-])O.Oc1ccnc2cc(-c3ccccc3)ccc12>>O=[N+]([O-])c1cnc2cc(-c3ccccc3)ccc2c1O",
        "output": "328"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COc1ccc2ncc(C(N)=O)c(Cl)c2c1.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COc1ccc2ncc(C#N)c(Cl)c2c1",
        "output": "624"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].COc1ccc(N2CCNCC2)c(OC)c1.Cc1c(C)c2c(c(C)c1Br)CC(C)(C)O2.Cc1ccccc1.O.[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COc1ccc(N2CCN(c3c(C)c(C)c4c(c3C)CC(C)(C)O4)CC2)c(OC)c1",
        "output": "294"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.CN(Cc1ccccc1)c1cc(Cl)cc(Cl)c1.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>CN(Cc1ccccc1)c1cc(Cl)c(C=O)c(Cl)c1",
        "output": "239"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CS(=O)c1nc(-c2ccc(Cl)c(Cl)c2)c2c(N)c(C(N)=O)sc2n1.NC1CCCCC1>>NC(=O)c1sc2nc(NC3CCCCC3)nc(-c3ccc(Cl)c(Cl)c3)c2c1N",
        "output": "666"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n([C@@H]3CCNC3)c12.CS(=O)(=O)Cl.Cl.Cl>>COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n([C@@H]3CCN(S(C)(=O)=O)C3)c12",
        "output": "584"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN(C)C=O.Cl.NCCN1c2ccccc2CCc2ccc(Cl)cc21.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1>>O=S(=O)(NCCN1c2ccccc2CCc2ccc(Cl)cc21)c1ccc(C(F)(F)F)cc1",
        "output": "43"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1CNCCO1.CCN(C(C)C)C(C)C.CN(C)C=O.C[C@@H](C(=O)O)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O.ClCCl>>CC1CN(C(=O)[C@H](C)N2CC[C@H](NS(=O)(=O)c3ccc4cc(Cl)ccc4c3)C2=O)CCO1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CI.CN(C)C=O.COc1cc(OC)c2[nH]cc(-c3cc4cccnc4n3S(=O)(=O)c3ccc(C)cc3)c2c1.O.[H-].[Na+]>>COc1cc(OC)c2c(c1)c(-c1cc3cccnc3n1S(=O)(=O)c1ccc(C)cc1)cn2C",
        "output": "191"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cl.NCc1ccc(C(=O)O)cc1.O.[Na+].[OH-]>>CC(C)(C)OC(=O)NCc1ccc(C(=O)O)cc1",
        "output": "686"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.NC[C@H]1CC[C@@H](CCOc2ccccc2)CC1.O=C(O)c1cnc(O)c(Cl)c1>>O=C(NC[C@@H]1CC[C@H](CCOc2ccccc2)CC1)c1cnc(O)c(Cl)c1",
        "output": "674"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@@H](N)Cc1ccccc1.CCN1CCOCC1.CCOC(C)=O.NC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)O.Oc1cccc2[nH]nnc12>>CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(C)N1CCn2c(Cc3ccc(Cl)cc3-c3ccncc3)nc(=O)c(OCc3ccccc3)c2C1=O.O=S(=O)(O)O>>CC(C)N1CCn2c(Cc3ccc(Cl)cc3-c3ccncc3)nc(=O)c(O)c2C1=O",
        "output": "492"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NCCC(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COc1ccc(C2=NN(C3CCNCC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>COc1ccc(C2=NN(C3CCN(C(=O)CCNC(=O)OC(C)(C)C)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CCN(CC)CC.COc1ccc(-c2cccc3c2CCC3=O)c(OCC2(CN)COC2)c1OC.ClCCl.O>>COc1ccc(-c2cccc3c2CCC3=O)c(OCC2(CNC(C)=O)COC2)c1OC",
        "output": "45"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)CN1CCCC(c2ccccc2)(c2ccccc2)C1=O>>CC(C)(C)OC(=O)N1CCC(NC(=O)CN2CCCC(c3ccccc3)(c3ccccc3)C2=O)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C(NC(C(=O)O)c1cccs1)c1cccn(Cc2ccc(F)c(F)c2)c1=O.O=S(Cl)Cl>>COC(=O)C(NC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)c1cccs1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CCOP(=O)(CCc1ccncc1)OCC.O=C(OO)c1cccc(Cl)c1>>CCOP(=O)(CCc1cc[n+]([O-])cc1)OCC",
        "output": "262"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.CCCCCC.COc1cccc(CNC(=O)c2[nH]c3ccc(Cl)cc3c2S(=O)(=O)c2ccccc2)c1.ClCCl.O=C([O-])O.[Na+]>>O=C(NCc1cccc(O)c1)c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1",
        "output": "732"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(N[C@@H]1C[C@H]1c1ccccc1)C1CCN(C(=O)OC(C)(C)C)CC1.Cl.ClC(Cl)Cl>>CC(N[C@@H]1C[C@H]1c1ccccc1)C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.C1COCCO1.CCOC(=O)C1CNC(=O)C1C.[H-].[Na+]>>CCOC(=O)C1CN(Cc2ccccc2)C(=O)C1C",
        "output": "774"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)Cn1nc(C(F)(F)F)c2c1C1CC1CO2.CCOC(C)=O.CO.O>>O=C(O)Cn1nc(C(F)(F)F)c2c1C1CC1CO2",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COC(=O)C1CCC(=O)CC1(C)C.Cl.[BH4-].[Na+]>>COC(=O)C1CCC(O)CC1(C)C",
        "output": "91"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCC.CCOC(C)=O.CO.NN.O.O=C(N[C@@H](c1ccc(OC(F)(F)F)c(F)c1)c1ncccc1F)c1cc(O)c([N+](=O)[O-])cn1.[Ni]>>Nc1cnc(C(=O)N[C@@H](c2ccc(OC(F)(F)F)c(F)c2)c2ncccc2F)cc1O",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(Cl)Cl.CC(Cl)OC(=O)Cl.CN(C(=O)COc1cccc(Cl)c1)C1CCN(Cc2ccccc2)CC1>>CN(C(=O)COc1cccc(Cl)c1)C1CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cc1ccc2sc(-c3nn(COCC[Si](C)(C)C)cc3C(=O)NC(C)(C)CO)cc2c1.ClCCl.O=C(O)C(F)(F)F.[NH4+].[OH-]>>Cc1ccc2sc(-c3n[nH]cc3C(=O)NC(C)(C)CO)cc2c1",
        "output": "813"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COc1cc(OC)c(F)c(N2Cc3cnc(Nc4c(C)cccc4[N+](=O)[O-])cc3C3(CC3)C2=O)c1F.[Pd]>>COc1cc(OC)c(F)c(N2Cc3cnc(Nc4c(C)cccc4N)cc3C3(CC3)C2=O)c1F",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.Cl.NCc1nccnc1Cl.O=CO>>O=CNCc1nccnc1Cl",
        "output": "370"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCO.CCOC(=O)C1C2Cc3cc(NCc4cc(-c5ccc(OCCCS(C)(=O)=O)nc5C)ccc4F)ncc3C21.Cl.O.[Li+].[OH-]>>Cc1nc(OCCCS(C)(=O)=O)ccc1-c1ccc(F)c(CNc2cc3c(cn2)C2C(C3)C2C(=O)O)c1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(-n2ccnc2[C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)(F)F)c3c2CCCC3)cc1.Cl.NC(Cc1cc(F)cc(F)c1)c1cnc(-c2ccc(Cl)cc2)o1.O=C(O)Cn1nc(C(F)(F)F)c2c1CCCC2>>O=C(Cn1nc(C(F)(F)F)c2c1CCCC2)NC(Cc1cc(F)cc(F)c1)c1cnc(-c2ccc(Cl)cc2)o1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.Cl.ClCCl.Cn1ncc2c1Nc1cc(Cl)ccc1N(C(=O)c1ccc(CN)c(F)c1)C2.O=C(Cl)C1CC1.O=C([O-])C1=NN(c2ccc(S(=O)(=O)[O-])cc2)C(=O)C1N=Nc1ccc(S(=O)(=O)[O-])cc1.[Na+].[Na+].[Na+]>>Cn1ncc2c1Nc1cc(Cl)ccc1N(C(=O)c1ccc(CNC(=O)C3CC3)c(F)c1)C2",
        "output": "206"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(OCC)P(=O)(CCCN(C)Cc1ccc(Cl)cc1)OCC.O.O.[Li+].[OH-]>>CCOC(OCC)P(=O)(O)CCCN(C)Cc1ccc(Cl)cc1",
        "output": "618"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)OCC1(CC1)N(C(=O)C1CCOCC1)C2.NO.[Na+].[OH-]>>O=C(NO)c1ccc2c(c1)OCC1(CC1)N(C(=O)C1CCOCC1)C2",
        "output": "988"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC(C)CBr.Oc1ccc(-c2ccc(Cn3cc4nc(-c5cccc(F)c5F)nc-4cn3)nn2)c(C(F)(F)F)c1>>CCC(C)COc1ccc(-c2ccc(Cn3cc4nc(-c5cccc(F)c5F)nc-4cn3)nn2)c(C(F)(F)F)c1",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)c1c[nH]c2ccc(O)cc12.CCOC(C)=O.CS(C)=O.Cc1cc([N+](=O)[O-])cc(C)c1F.O.O=C([O-])[O-].[K+].[K+]>>Cc1cc([N+](=O)[O-])cc(C)c1Oc1ccc2[nH]cc(C(C)C)c2c1",
        "output": "564"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.Cc1ccc(N)cc1.O=Cc1ccccc1[N+](=O)[O-]>>Cc1ccc(N=Cc2ccccc2[N+](=O)[O-])cc1",
        "output": "329"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CNC(C)CO.N#Cc1cc([N+](=O)[O-])c(F)cc1Br.O>>CC(CO)N(C)c1cc(Br)c(C#N)cc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCC1=C(C)C(=O)C(C(C)(C)CC(=O)O)=C(C)C1=O.Oc1ccc(N(CCCl)CCCl)cc1>>CCCC1=C(C)C(=O)C(C(C)(C)CC(=O)Oc2ccc(N(CCCl)CCCl)cc2)=C(C)C1=O",
        "output": "108"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)OCc1ccccc1CN1C(=O)c2ccccc2C1=O.CCOCC.CO.Cl.O>>O=C1c2ccccc2C(=O)N1Cc1ccccc1CO",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "N[C@@H]1CC[C@@H](NC(=O)c2c[nH]c3c(-c4ccccc4OCC4CC4)ncnc23)CC1.O=C(Cl)C1CC1>>O=C(N[C@@H]1CC[C@@H](NC(=O)C2CC2)CC1)c1c[nH]c2c(-c3ccccc3OCC3CC3)ncnc12",
        "output": "45"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cn1cc(C(=O)NCCCO)c(Nc2ccc(C#CCO)cc2F)cc1=O.[Pd]>>Cn1cc(C(=O)NCCCO)c(Nc2ccc(CCCO)cc2F)cc1=O",
        "output": "717"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.[Pd].c1ccc(COc2ccccc2-c2cocn2)cc1>>Oc1ccccc1-c1cocn1",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.Cn1ccc2cc(N(C(=O)c3cc(-c4ccc(OCC(=O)N5CCCCC5)cc4C(=O)N4Cc5ccccc5C[C@H]4CN4CCOCC4)n4c3CCCC4)c3ccc(O[Si](C)(C)C(C)(C)C)cc3)cnc21.O=C([O-])O.[F-].[Na+]>>Cn1ccc2cc(N(C(=O)c3cc(-c4ccc(OCC(=O)N5CCCCC5)cc4C(=O)N4Cc5ccccc5C[C@H]4CN4CCOCC4)n4c3CCCC4)c3ccc(O)cc3)cnc21",
        "output": "754"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(F)c(B(O)O)c1.ClCCl.Cl[Pd]Cl.O=C(O)c1nc(Br)ccc1F.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1ccc(F)c(-c2ccc(F)c(C(=O)O)n2)c1",
        "output": "869"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)C[AlH]CC(C)C.CCOC(=O)c1cn2cc(Br)sc2n1.ClCCl.O>>OCc1cn2cc(Br)sc2n1",
        "output": "286"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCl.CCN(CC)CC.COc1ccc(C(=O)N2CCCc3cc(C4=NN(C(=O)OCCCN5CCNCC5)C(=O)SC4C)ccc32)cc1OC.Cc1ccccc1>>CCN1CCN(CCCOC(=O)N2N=C(c3ccc4c(c3)CCCN4C(=O)c3ccc(OC)c(OC)c3)C(C)SC2=O)CC1",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CCOCC1.COc1cc2c(cc1F)C1(CO2)C(=O)Nc2ccccc21.Cc1noc2cc3c(cc12)C1(CO3)C(=O)Nc2ccccc21.FC(F)(F)c1ccc(CBr)o1>>COc1cc2c(cc1F)C1(CO2)C(=O)N(CC2CCOCC2)c2ccccc21",
        "output": "367"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)C(CNC(C)=O)c1ccc(C(=O)OC(C)(C)C)cc1.O=C(O)CC(O)(CC(=O)O)C(=O)O.[K+].[OH-]>>CC(=O)NCC(C(=O)O)c1ccc(C(=O)OC(C)(C)C)cc1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC[Sn](CCC)(CCC)CCCBr.CCOCC.CN(C)CCCN.O=C([O-])O.[Na+]>>CCC[Sn](CCC)(CCC)CCCNCCCN(C)C",
        "output": "147"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)Cl.Nc1cc(Br)cnc1N.c1ccncc1>>CCOC(=O)Nc1cc(Br)cnc1N",
        "output": "763"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1ccc2nc(-c3cccc(N)c3)oc2c1.O=C(O)c1ccc2c(c1)C(=O)OC2=O>>COC(=O)c1ccc2nc(-c3cccc(N4C(=O)c5ccc(C(=O)O)cc5C4=O)c3)oc2c1",
        "output": "475"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.COc1ccc([N+](=O)[O-])c(NC2COC(C)(C)OC2)n1.[H][H].[Pd]>>COc1ccc(N)c(NC2COC(C)(C)OC2)n1",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.N.O=C(O)c1c(C(F)(F)F)ccc(Cl)c1F.O=S(Cl)Cl>>NC(=O)c1c(C(F)(F)F)ccc(Cl)c1F",
        "output": "358"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)COc1ccc(OC(C)=O)cc1.C[O-].Cl.[Na+]>>COC(=O)COc1ccc(O)cc1",
        "output": "22"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COc1cc(C=O)cc(OC)c1OC.C[C@H](N)[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1>>COc1cc(CN[C@@H](C)[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)cc(OC)c1OC",
        "output": "468"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CNOC.Cl.ClCCCl.O=C(O)c1ccc(CO)cc1>>CON(C)C(=O)c1ccc(CO)cc1",
        "output": "828"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[Si](C)(C)Oc1ccc(C2(O)CCC(=O)CC2)cc1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>O=C1CCC(O)(c2ccc(O)cc2)CC1",
        "output": "754"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc(-c2cc(Oc3ncccn3)cc(C(=O)O)c2)cc1.Cc1ccc([C@@H](C)N)cn1.Cl.Cl.F[P-](F)(F)(F)(F)F>>Cc1ccc(-c2cc(Oc3ncccn3)cc(C(=O)N[C@H](C)c3ccc(C)nc3)c2)cc1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)O.CCCCCCCNC(=O)N(C)c1cccc(-c2ccc(/C=C(\\OC)C(=O)OC)cc2)c1.[Na+].[OH-]>>CCCCCCCNC(=O)N(C)c1cccc(-c2ccc(/C=C(\\OC)C(=O)O)cc2)c1",
        "output": "58"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COc1ccc2c(c1)C(=O)CC(C)(C)C2.ClCCl>>CC1(C)CC(=O)c2cc(O)ccc2C1",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCI.CCOC(C)=O.CN(C)C=O.O.O=C([O-])[O-].O=Cc1cc(C2CC2)c(-c2ccc(F)cc2)cc1O.[K+].[K+]>>CCOc1cc(-c2ccc(F)cc2)c(C2CC2)cc1C=O",
        "output": "198"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCc1nc(N)c2c(n1)c(C#CCCCC=O)cn2COCc1ccccc1.CCCCc1nc(N)c2c(n1)c(C#CCCCCO)c(C)n2COCc1ccccc1>>CCCCc1nc(N)c2c(n1)c(C#CCCCC=O)c(C)n2COCc1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1cnc(N[C@H]2CC[C@@H](NCc3ccccc3)CC2)cc1N(C)CCc1ccccc1.[C].[Pd]>>Cc1cnc(N[C@H]2CC[C@@H](N)CC2)cc1N(C)CCc1ccccc1",
        "output": "561"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.O=[N+]([O-])c1cccc(-c2ccncn2)c1.[Pd]>>Nc1cccc(-c2ccncn2)c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CN1CCOCC1.CO.COc1nc(OC)nc([N+]2(C)CCOCC2)n1.Cc1ccc(N2CCCNCC2)c(C)c1.Cl.O.O.O=C(O)c1ccc(N2CCCS2(=O)=O)cc1.[Cl-]>>Cc1ccc(N2CCCN(C(=O)c3ccc(N4CCCS4(=O)=O)cc3)CC2)c(C)c1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)c1ccc(CNCCc2ccc(Cl)c(Cl)c2)cc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O.O=C(O)c1cccc2cc[nH]c12>>CC(C)(C)c1ccc(CN(CCc2ccc(Cl)c(Cl)c2)C(=O)c2cccc3cc[nH]c23)cc1",
        "output": "893"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COc1cc(N)c(CO)cn1.O=[Mn]=O>>COc1cc(N)c(C=O)cn1",
        "output": "520"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)N.CCN(CC)CC.CN(C)C=O.Cc1ncccc1C(=O)O.ClCCCl.On1nnc2ccccc21>>Cc1ncccc1C(=O)NC(C)C",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CCOC(=O)c1cn([C@@H]2C[C@@H]2F)c2c(C)c(F)cc(N)c2c1=O.O.O=S(=O)(O)O>>Cc1c(F)cc(N)c2c(=O)c(C(=O)O)cn([C@@H]3C[C@@H]3F)c12",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN[C@@H]1CC[C@@H](C(=O)O)CC1.C[Si](C)(C)N[Si](C)(C)C.Cl.Cl.O.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1.[Na+].[OH-]>>CN([C@@H]1CC[C@@H](C(=O)O)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1",
        "output": "99"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)Cc1c(C(=O)OCC)c2cc(O)ccc2n1-c1ccc(C(C)C)cc1.OB(O)c1ccc(C(F)(F)F)cc1>>CCOC(=O)Cc1c(C(=O)OCC)c2cc(Oc3ccc(C(F)(F)F)cc3)ccc2n1-c1ccc(C(C)C)cc1",
        "output": "920"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCC1CO1.CN(C)C=O.COc1cc2c(Oc3cc(C)c(C)nc3-c3nc(C)c(C)s3)ccnc2cc1O.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(Oc3cc(C)c(C)nc3-c3nc(C)c(C)s3)ccnc2cc1OCC1CO1",
        "output": "18"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.Cc1cc(CO[Si](C)(C)C(C)(C)C)ccc1Br.Cc1cccc(C=O)c1.II.[Cl-].[Mg].[NH4+]>>Cc1cccc(C(O)c2ccc(CO[Si](C)(C)C(C)(C)C)cc2C)c1",
        "output": "379"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(=O)(=O)Cl.Cc1cccc(C(CO)NC(=O)OC(C)(C)C)n1.ClCCl.O=C([O-])O.[Na+]>>Cc1cccc(C(COS(C)(=O)=O)NC(=O)OC(C)(C)C)n1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(O)C3)C(C)CCC1=O)C(C)CC2OC.CCN(C(C)C)C(C)C.CN(C)c1ccncc1.ClCCl.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(OS(=O)(=O)c4ccccc4[N+](=O)[O-])C3)C(C)CCC1=O)C(C)CC2OC",
        "output": "197"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCn1c2c(c3cc(C(=O)O)ccc31)CC(C1CCOCC1)CC2.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNCCCC(=O)OC.Cl.F[P-](F)(F)(F)(F)F>>CCn1c2c(c3cc(C(=O)N(C)CCCC(=O)OC)ccc31)CC(C1CCOCC1)CC2",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C/C(=C\\COC1CCCCO1)CC/C=C(\\C)CCC(O)c1ccc(Br)cc1.ClCCl.O=C([O-])[O-].[Mn+4].[Na+].[Na+].[O-2].[O-2]>>C/C(=C\\COC1CCCCO1)CC/C=C(\\C)CCC(=O)c1ccc(Br)cc1",
        "output": "32"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1cc2c(cc1[N+](=O)[O-])OCO2.O.[Cl-].[Fe].[NH4+]>>Cc1cc2c(cc1N)OCO2",
        "output": "202"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1ccc(CCC(=O)OC)c(F)c1.Clc1cc(Cl)cc(Br)c1>>COC(=O)CCc1ccc(C#Cc2cc(Cl)cc(Cl)c2)cc1F",
        "output": "659"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC(C(=O)OC)c1c(C)nc2sc3c(c2c1-c1cccs1)CCC3.CO.Cl.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc2sc3c(c2c1-c1cccs1)CCC3",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Cl.O=[N+]([O-])c1ccc(CCBr)cc1.O=[N+]([O-])c1ccc(CCN2CCNCC2)cc1>>O=[N+]([O-])c1ccc(CCN2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)cc1",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NC[C@H]1CN(c2ccc3c(c2)CCCc2cnoc2-3)C(=O)O1.O=C(O)CC(F)(F)F>>O=C(CC(F)(F)F)NC[C@H]1CN(c2ccc3c(c2)CCCc2cnoc2-3)C(=O)O1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)C[C@@H]1Cc2cc(Br)c3[nH]nc(Br)c3c2CN(CC(F)(F)F)C1=O.Cl.O.O.[Li+].[OH-]>>O=C(O)C[C@@H]1Cc2cc(Br)c3[nH]nc(Br)c3c2CN(CC(F)(F)F)C1=O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(Cl)OC(=O)Cl.ClCCl.OCc1ccccc1.c1ccncc1>>CC(Cl)OC(=O)OCc1ccccc1",
        "output": "144"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)OC(=O)N=NC(=O)OC(C)C.COC(=O)C[C@@H]1COc2cc(O)ccc21.Cc1cc(O[C@@H]2CCOC2)cc(C)c1-c1cccc(CO)c1.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)C[C@@H]1COc2cc(OCc3cccc(-c4c(C)cc(O[C@@H]5CCOC5)cc4C)c3)ccc21",
        "output": "347"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)C(C)(C)c1cccc(OC)c1.[Li+].[OH-]>>COc1cccc(C(C)(C)C(=O)O)c1",
        "output": "203"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1csc(-c2ccc(-c3onc(C)c3NC(=O)OC(C)c3ccccc3Cl)cc2)n1.Cl.[Li+].[OH-]>>Cc1noc(-c2ccc(-c3nc(C(=O)O)cs3)cc2)c1NC(=O)OC(C)c1ccccc1Cl",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CC(=O)SCC(Cc1ccccc1)C(=O)O.CCN(CC)CC.Cc1ccc(S(=O)(=O)[O-])cc1.ClC(Cl)Cl.NCC(=O)OCc1ccccc1.On1nnc2ccccc21>>CC(=O)SCC(Cc1ccccc1)C(=O)NCC(=O)OCc1ccccc1",
        "output": "132"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.O.O=C1CCC(=O)N1Br.O=C1c2ccccc2C(=O)N1CC1CN2CCOc3cccc1c32>>O=C1c2ccccc2C(=O)N1CC1CN2CCOc3cc(Br)cc1c32",
        "output": "4"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Br.BrBr.CC(=O)C1(c2ccccc2)CCC1.CO.O>>O=C(CBr)C1(c2ccccc2)CCC1",
        "output": "173"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1ccc(OCCC2CCN(C(=O)OC(C)(C)C)CC2)nc1.[Li+].[OH-]>>CC(C)(C)OC(=O)N1CCC(CCOc2ccc(C(=O)O)cn2)CC1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccc(Br)cc1.C1CCOC1.C1CSCCN1.O=C([O-])[O-].[K+].[K+]>>Brc1ccc(CN2CCSCC2)cc1",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCNCC(O)(CNc1cc(C)cc2c1cnn2-c1ccc(F)cc1)C(F)(F)F.O=C(O)c1ccccc1>>CCN(CC(O)(CNc1cc(C)cc2c1cnn2-c1ccc(F)cc1)C(F)(F)F)C(=O)c1ccccc1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(N)CO.CC1CCCN1c1cccc(Nc2cc(-c3cccc(C(=O)O)c3)nn3ccnc23)n1.CCN=C=NCCCN(C)C.CN(C)C=O.ClCCl.Cn1ccnc1>>CC(CO)NC(=O)c1cccc(-c2cc(Nc3cccc(N4CCCC4C)n3)c3nccn3n2)c1",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CNc1cccc(OCc2ccccc2)c1[N+](=O)[O-].CO.NN.O>>CNc1cccc(OCc2ccccc2)c1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)C1CCCCN1C(=O)c1ccc(COc2ccc(-c3ccccc3)cc2)o1.CO.O.O.[Li+].[OH-]>>O=C(O)C1CCCCN1C(=O)c1ccc(COc2ccc(-c3ccccc3)cc2)o1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)N1CCN(C(=O)c2ccc3[nH]c(C(=O)O)cc3c2)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.FC1(F)CCNCC1.F[B-](F)(F)F>>CC(C)N1CCN(C(=O)c2ccc3[nH]c(C(=O)N4CCC(F)(F)CC4)cc3c2)CC1",
        "output": "605"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.Cc1ccc(S(=O)(=O)OCC(C)c2ccc(C(=O)c3ccccc3)cc2)cc1.c1ccc(CN2CCNCC2)cc1>>CC(CN1CCN(Cc2ccccc2)CC1)c1ccc(C(=O)c2ccccc2)cc1",
        "output": "429"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C=Cc1ccc(N)c(O)c1.ClC(Cl)Cl.O=C(Cl)CCl.O=C([O-])O.[Na+]>>CCOC(=O)C=Cc1ccc(NC(=O)CCl)c(O)c1",
        "output": "9"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CCCCCCCOC1CCCCO1.CO.ClC(Cl)Cl>>C#CCCCCCCO",
        "output": "543"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCBr.CCCCCCCCOc1cc2c(c(F)n1)C(F)(F)C(c1ccc(O)cn1)CC2.CN(C)C=O.O.[H-].[Na+]>>CCCCCCCCOc1ccc(C2CCc3cc(OCCCCCCCC)nc(F)c3C2(F)F)nc1",
        "output": "608"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COc1cc(C(=O)O)cc(CCCO)c1OC.C[Si](C)(C)C=[N+]=[N-]>>COC(=O)c1cc(CCCO)c(OC)c(OC)c1",
        "output": "195"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.CCOC(=O)C(C)(C)Oc1ccc(OCCc2ccc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C.[Na+].[OH-]>>Cc1cc(OCCc2ccc(-c3ccc(C(F)(F)F)cc3)nc2C)ccc1OC(C)(C)C(=O)O",
        "output": "192"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CN.CO.COC(=O)COc1ccc(C(C)=O)cc1-c1cccc(C(F)(F)F)c1.Cl.[BH3-]C#N.[Na+]>>CNC(C)c1ccc(OCC(=O)OC)c(-c2cccc(C(F)(F)F)c2)c1",
        "output": "693"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1ccc2c(-c3ccc(C#N)cc3)c(-c3ccc(OC)cc3)c(C)nn12.CN(C)C=O.OO.[Na+].[OH-]>>CCc1ccc2c(-c3ccc(C(N)=O)cc3)c(-c3ccc(OC)cc3)c(C)nn12",
        "output": "180"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)n1c(-c2ccccc2C#N)nc2cc(-c3cnc(N)nc3)ccc21.CCO.NO>>CC(C)(C)n1c(-c2ccccc2C(=N)NO)nc2cc(-c3cnc(N)nc3)ccc21",
        "output": "854"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Nc1ccc(Cl)cc1.O.O=N[O-].[Na+]>>NNc1ccc(Cl)cc1",
        "output": "109"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCNC(=O)c1ccc(NC(CC(C)C)c2oc3ccc(OC)cc3c2C)cc1.[Na+].[OH-]>>COc1ccc2oc(C(CC(C)C)Nc3ccc(C(=O)NCCC(=O)O)cc3)c(C)c2c1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CI.O.O=Cc1ccc(CO)cc1.[H-].[Na+]>>COCc1ccc(C=O)cc1",
        "output": "140"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCCBr.CCC(C)=O.CCCCc1oc2ccccc2c1C(=O)c1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>CCCCc1oc2ccccc2c1C(=O)c1ccc(OCCBr)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1cc2c(=O)c(Cc3cccnc3)cn3c4cc(Br)ccc4c(c1)c23.ClCCl.O=C([O-])[O-].[Na+].[Na+]>>O=c1c(Cc2cccnc2)cn2c3cc(Br)ccc3c3cc(O)cc1c32",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2ccn(C3CCN(CCc4c(OC)ccc5c4OC(C)(C)CC5=O)CC3)c2c1.Cl.[Na+].[OH-]>>COc1ccc2c(c1CCN1CCC(n3ccc4ccc(C(=O)O)cc43)CC1)OC(C)(C)CC2=O",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CI.CN(C)C=O.COC(=O)c1sc(C2=CCC(C)(C)CC2)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)[C@@H]1CC[C@@H](O)CC1.[H-].[Na+]>>COC(=O)c1sc(C2=CCC(C)(C)CC2)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)[C@@H]1CC[C@@H](OC)CC1",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC(O)C(=O)O.O.[Na+].[OH-]>>CC(C)(C)OC(=O)NCC(O)C(=O)O",
        "output": "631"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COc1ccc(Oc2cccc(C=O)c2)cc1.[BH4-].[Na+]>>COc1ccc(Oc2cccc(CO)c2)cc1",
        "output": "356"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C[AlH]CC(C)C.COC(=O)c1ccc(Br)c(OC)n1.ClCCl.O=C([O-])C(O)C(O)C(=O)[O-]>>COc1nc(CO)ccc1Br",
        "output": "546"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.O=C(Cl)N1CCCCC1.O=C(O)C(F)(F)F.O=C1NC(C2CCCNC2)=NC12CCN(S(=O)(=O)c1cccc(Cl)c1)CC2>>O=C(N1CCCCC1)N1CCCC(C2=NC3(CCN(S(=O)(=O)c4cccc(Cl)c4)CC3)C(=O)N2)C1",
        "output": "258"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cc(C)c(N2CCNCC2)nc1C.O=C(Cl)c1ccc(I)cc1>>Cc1cc(C)c(N2CCN(C(=O)c3ccc(I)cc3)CC2)nc1C",
        "output": "201"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(-c2ccc(C=O)s2)cc1.NC12CC3CC(CC(C3)C1)C2>>COc1ccc(-c2ccc(CNC34CC5CC(CC(C5)C3)C4)s2)cc1",
        "output": "691"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.O=C(NCc1ccccc1Cl)c1cccnc1Oc1cccc([N+](=O)[O-])c1.O=[Pt]=O.[H][H]>>Nc1cccc(Oc2ncccc2C(=O)NCc2ccccc2Cl)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1nc(CCc2ccc(CCNC(=S)NC(=O)c3ccccc3)cc2)cs1.CCO.Cl.[Na+].[OH-]>>CC(=O)Nc1nc(CCc2ccc(CCNC(N)=S)cc2)cs1",
        "output": "80"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1C[C@H](Sc2ccc(F)cc2Cl)C[C@H]1C(=O)NC1(C#N)CC1.O=CO>>N#CC1(NC(=O)[C@@H]2C[C@@H](Sc3ccc(F)cc3Cl)CN2)CC1",
        "output": "634"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrBr.CC(=O)O.CCOCC.Cc1ccc(N)nc1.[Na+].[OH-]>>Cc1cnc(N)c(Br)c1",
        "output": "292"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)O.Cl[Co]Cl.O.O=C1NC(=O)C(=Cc2ccc(OCC(O)c3cccc(F)c3)cc2)S1.[BH4-].[Na+].c1ccc(-c2ccccn2)nc1>>O=C1NC(=O)C(Cc2ccc(OCC(O)c3cccc(F)c3)cc2)S1",
        "output": "762"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCc1nc2c(C)ccc(OCCCCCN3CNC4CC=CC=C43)c2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCCCc1nc2c(C)ccc(OCCCCCN3CNC4CC=CC=C43)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(-c2cc(Cl)nnc2-c2ccc(OC)cc2)cc1.N#Cc1cccc(O)c1>>COc1ccc(-c2cc(Oc3cccc(C#N)c3)nnc2-c2ccc(OC)cc2)cc1",
        "output": "603"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)c1cc2ccccc2o1.[Na+].[OH-]>>COc1ccc(C[C@H](NC(=O)c2cc3ccccc3o2)C(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.Cc1c(C(=O)OCc2ccccc2)cc(Br)cc1[N+](=O)[O-].O.[Cl-].[Fe].[NH4+]>>Cc1c(N)cc(Br)cc1C(=O)OCc1ccccc1",
        "output": "481"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.NCCn1cccn1.O.O=[N+]([O-])c1ccc(F)cc1>>O=[N+]([O-])c1ccc(NCCn2cccn2)cc1",
        "output": "572"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(=O)C(CNC(=O)OC(C)(C)C)Cc1ccc(OCCO)cc1.[Li+].[OH-]>>CC(C)(C)OC(=O)NCC(Cc1ccc(OCCO)cc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CCC1CCCCC1=O.CCO.Cl.NO.O.[Na+]>>CCC1CCCCC1=NO",
        "output": "86"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.CC#N.ClCCl.N#Cc1ccc(O)cc1F.O=C([O-])[O-].[K+].[K+]>>N#Cc1ccc(OCc2ccccc2)cc1F",
        "output": "127"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.C1COCCO1.CC1(NC(=O)OCc2ccccc2)CCN(C(=O)OC(C)(C)C)CC1.Cl>>CC1(NC(=O)OCc2ccccc2)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COc1ccc(Oc2ncc(-c3cc(C(C)N4C(=O)c5ccccc5C4=O)on3)s2)c(Cl)c1.NN.O>>COc1ccc(Oc2ncc(-c3cc(C(C)N)on3)s2)c(Cl)c1",
        "output": "242"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)OB(c2ccc(-c3cnc(N)nc3)c(F)c2)OC1(C)C.Nc1ccnc(Oc2ccccc2Br)n1>>Nc1ccnc(Oc2ccccc2-c2ccc(-c3cnc(N)nc3)c(F)c2)n1",
        "output": "933"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)N=NC(=O)OCC.COCCSc1ncnc2cc(O)ccc12.ClCCl.O=S1(=O)CCN(CCCO)CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COCCSc1ncnc2cc(OCCCN3CCS(=O)(=O)CC3)ccc12",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)/C=C/c1c(N2CCC[C@@H](OC(=O)NCCCl)C2)nc2cc(C(=O)Nc3nc(C(C)(C)C)cs3)ccn2c1=O.Cl>>CC(C)(C)c1csc(NC(=O)c2ccn3c(=O)c(/C=C/C(=O)O)c(N4CCC[C@@H](OC(=O)NCCCl)C4)nc3c2)n1",
        "output": "158"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)c1ccncc1.ClCCl.O=C(Cl)CCl.O=C([O-])O.O[C@@H]1CCCC[C@H]1c1ccccc1.[Na+]>>O=C(CCl)O[C@@H]1CCCC[C@H]1c1ccccc1",
        "output": "126"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Cc1[nH]cc(C(O)C(F)(F)F)c(=O)c1OCc1ccccc1.[Pd]>>Cc1[nH]cc(C(O)C(F)(F)F)c(=O)c1O",
        "output": "264"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.C1CCOC1.Cn1cc(-c2cc(Oc3ccc(NC(=O)NC4CC(=O)N(C(C)(C)C)C4)c(F)c3)ccn2)cn1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cn1cc(-c2cc(Oc3ccc(NC(=O)NC4CCN(C(C)(C)C)C4)c(F)c3)ccn2)cn1",
        "output": "112"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.Fc1ccc(OC2CCNCC2)c(Br)c1>>CS(=O)(=O)N1CCC(Oc2ccc(F)cc2Br)CC1",
        "output": "584"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)c1noc(N2CCC(NC3CC3)CC2)n1.Cc1nccn1-c1ccc(C(=O)O)cc1>>Cc1nccn1-c1ccc(C(=O)N(C2CC2)C2CCN(c3nc(C(C)C)no3)CC2)cc1",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.CO.COc1ccc(C=Cc2nc(Cc3ccccc3)no2)cc1OC.ClC(Cl)Cl.ClCCl.O=C([O-])[O-].[Na+].[Na+]>>Oc1ccc(C=Cc2nc(Cc3ccccc3)no2)cc1O",
        "output": "19"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NCCO.O.O=C(O)c1ccc(Cn2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c32)cc1.O=C([O-])O.O=C1CCC(=O)N1O.[Na+]>>O=C(NCCO)c1ccc(Cn2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c32)cc1",
        "output": "821"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC2(CC1)CCN(c1ccc(C3CCC(O[Si](C)(C)C(C)(C)C)CC3)cc1F)C2=O.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.CO.ClCCl.[F-]>>CC(C)(C)OC(=O)N1CCC2(CC1)CCN(c1ccc(C3CCC(O)CC3)cc1F)C2=O",
        "output": "708"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Cl.Nc1ccc(N2CCSCC2)cc1>>COc1ccc2nc(Nc3ccc(N4CCSCC4)cc3)c3n[nH]cc3c2c1",
        "output": "998"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1CN(S(=O)(=O)c2ccc3ccccc3c2)CCN1.O=C(Cl)C1CCN(c2ccncc2)CC1>>CC1CN(S(=O)(=O)c2ccc3ccccc3c2)CCN1C(=O)C1CCN(c2ccncc2)CC1",
        "output": "125"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.CNOC.Cl.ClCCCl.ClCCl.O.O=C(c1ccc(Cl)cc1)[C@@H]1CC[C@H](C(=O)O)CC1.On1nnc2ccccc21>>CON(C)C(=O)[C@@H]1CC[C@H](C(=O)c2ccc(Cl)cc2)CC1",
        "output": "54"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C(=O)OC(C)(C)C)n1cc(F)c(-c2cc(Cl)ccc2C#N)cc1=O.O=C(O)C(F)(F)F>>CC(C(=O)O)n1cc(F)c(-c2cc(Cl)ccc2C#N)cc1=O",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccccc1.O=C(O)C1CCN(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)CC1.O=S(Cl)Cl>>O=C(Cl)C1CCN(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)CC1",
        "output": "53"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCc1nc(C(=O)N2CCOC3(CCN(Cc4cccc(CCOCCC(=O)OC(C)(C)C)c4Cl)CC3)C2)cs1.ClCCl.O=C(O)C(F)(F)F>>CCc1nc(C(=O)N2CCOC3(CCN(Cc4cccc(CCOCCC(=O)O)c4Cl)CC3)C2)cs1",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CO.Cl.Cn1ccnc1COc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc2cc(C3=NCC(CC(=O)O)S3)[nH]c12.On1nnc2ccccc21.[NH4+]>>Cn1ccnc1COc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc2cc(C3=NCC(CC(N)=O)S3)[nH]c12",
        "output": "313"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)C[AlH]CC(C)C.COC(=O)c1ccc(CS(=O)(=O)c2ccccc2)cc1.ClCCl.[Cl-].[NH4+]>>O=S(=O)(Cc1ccc(CO)cc1)c1ccccc1",
        "output": "444"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1cnc(Oc2cc3ccccc3cn2)c(Cl)c1.O=S(=O)(Cl)c1ccc(Cl)cc1>>O=S(=O)(Nc1cnc(Oc2cc3ccccc3cn2)c(Cl)c1)c1ccc(Cl)cc1",
        "output": "554"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)N1CCC(NC(=O)c2cc3cc(C(=O)O)ccc3n2Cc2cc(-c3ccc(Cl)s3)on2)CC1.CCO.CN(C)C=O.CN(C)c1ccncc1>>CCOC(=O)c1ccc2c(c1)cc(C(=O)NC1CCN(C(C)C)CC1)n2Cc1cc(-c2ccc(Cl)s2)on1",
        "output": "33"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(=O)c1cccc2nc(N3CC[C@H](NC(=O)c4nc(Cl)c(CC)[nH]4)[C@H](N)C3)sc12.O=C1CCOCC1.[Na+]>>CCOC(=O)c1cccc2nc(N3CC[C@H](NC(=O)c4nc(Cl)c(CC)[nH]4)[C@H](NC4CCOCC4)C3)sc12",
        "output": "236"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCCC[Sn](=O)CCCCCCCC.CN1C(C)(C)CC(O)CC1(C)C.COC(=O)CCc1cc(-n2nc3ccc(S(=O)(=O)c4ccccc4)cc3n2)c(O)c(C(C)(C)C)c1>>CN1C(C)(C)CC(OC(=O)CCc2cc(-n3nc4ccc(S(=O)(=O)c5ccccc5)cc4n3)c(O)c(C(C)(C)C)c2)CC1(C)C",
        "output": "289"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCOC(C)=O.CN(CCN)CCNC(=O)OC(C)(C)C.COc1c(C)c2c(c(O)c1C/C=C(\\C)CCC(=O)O)C(=O)OC2.ClCCCl>>COc1c(C)c2c(c(O)c1C/C=C(\\C)CCC(=O)NCCN(C)CCNC(=O)OC(C)(C)C)C(=O)OC2",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCC12CC3CC(CC(C3)C1)C2.CN(C)C=O.O=c1ccc(Br)c[nH]1.[H-].[Na+]>>O=c1ccc(Br)cn1CC12CC3CC(CC(C3)C1)C2",
        "output": "470"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCC(=O)Cl.COC(=O)c1ccc(CN2CCOc3ccc(N)cc32)c(OC)c1.ClCCl>>CCCCCC(=O)Nc1ccc2c(c1)N(Cc1ccc(C(=O)OC)cc1OC)CCO2",
        "output": "134"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCOC(C)=O.CN1CCNCC1.COc1ccc(Br)cc1[N+](=O)[O-].N#N.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>COc1ccc(N2CCN(C)CC2)cc1[N+](=O)[O-]",
        "output": "294"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.N#CC1CCC(=O)C1CCCCCCCO.OCCO.c1ccccc1>>N#CC1CCC2(OCCO2)C1CCCCCCCO",
        "output": "265"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.ClCCl.Cn1nc(-c2cnc3c(n2)c(C(=O)NC(C)(C)C)cn3COCC[Si](C)(C)C)c2cc(C#N)ccc21.NCCN.O.O=C(O)C(F)(F)F>>Cn1nc(-c2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c2cc(C#N)ccc21",
        "output": "981"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)Oc1ccc(Oc2nnc(-c3ccc(C(C)N4C(=O)c5ccccc5C4=O)s3)s2)cc1.CCO.ClCCl.ClCCl.NN.O>>CC(C)Oc1ccc(Oc2nnc(-c3ccc(C(C)N)s3)s2)cc1",
        "output": "242"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.Cc1cccc(O)c1.ClCCl.O=C(Cl)c1ccccc1>>Cc1cccc(OC(=O)c2ccccc2)c1",
        "output": "482"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(Cl)C(=O)Cl.O=C(O)CN1C(=O)O[C@H](c2ccccc2)[C@@H]1c1ccccc1.c1ccccc1>>O=C(Cl)CN1C(=O)O[C@H](c2ccccc2)[C@@H]1c1ccccc1",
        "output": "56"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CCN=C=NCCCN(C)C.CN(C)C=O.COc1ccc(Cn2cc(NC(=O)c3c(F)cccc3F)c(-c3nc(C(=O)O)c(CC(C)C)[nH]3)n2)cc1.Cl.On1nnc2ccccc21>>COc1ccc(Cn2cc(NC(=O)c3c(F)cccc3F)c(-c3nc(C(=O)N4CCOCC4)c(CC(C)C)[nH]3)n2)cc1",
        "output": "729"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=CN1CCNCC1.Sc1ncnc2c(N3CCOCC3)nc(Cl)nc12>>O=CN1CCN(c2nc(N3CCOCC3)c3ncnc(S)c3n2)CC1",
        "output": "36"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C#N)c1ccc(C(F)(F)F)cc1.N.[Ni]>>CC(C)(CN)c1ccc(C(F)(F)F)cc1",
        "output": "246"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(C(=O)OC(C)(C)C)C1CCC(=O)CC1.CN1CCNCC1.ClCCl.O=C([O-])O.[Na+].[Na+]>>CN1CCN(C2CCC(N(C)C(=O)OC(C)(C)C)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.COCCOc1cnc(Cl)nc1.ClCCl.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1cccc(Cl)c1.[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COCCOc1cnc(-c2cccc(Cl)c2)nc1",
        "output": "874"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C(O)c1cn(-c2ccc(F)cc2F)c2c(F)c(F)c(F)cc2c1=O.O=CNCCC1CNCCO1>>O=CNCCC1CN(c2c(F)cc3c(=O)c(C(=O)O)cn(-c4ccc(F)cc4F)c3c2F)CCO1",
        "output": "676"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.CS(C)=O.ClCCCCBr.N#Cc1c[nH]c(=O)[nH]c1=O.O.O=C([O-])[O-].[K+].[K+]>>N#Cc1cn(CCCCCl)c(=O)[nH]c1=O",
        "output": "327"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.Cc1ccc(S(=O)(=O)OCCc2ccccc2N2CCCCC2=O)cc1.Cl.Fc1cccc(C2CCCNC2)c1.O=C([O-])[O-].[K+].[K+]>>O=C1CCCCN1c1ccccc1CCN1CCCC(c2cccc(F)c2)C1",
        "output": "429"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(NCCCNC(=O)OC(C)(C)C)c1nc2onc(C(F)(F)F)c2c(=O)n1Cc1ccccc1.CCN(CC)CC.Cc1ccc(C(=O)Cl)cc1.ClCCl>>CCC(c1nc2onc(C(F)(F)F)c2c(=O)n1Cc1ccccc1)N(CCCNC(=O)OC(C)(C)C)C(=O)c1ccc(C)cc1",
        "output": "201"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N1CCNCC1.CO.COc1cc(CC=O)ccc1C#N.[BH3-]C#N.[Na+]>>COc1cc(CCN2CCN(C(=O)OC(C)(C)C)CC2)ccc1C#N",
        "output": "484"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1nn(-c2c(F)cccc2C=O)cc1CN1CCC2(CC1)OCC(F)(F)c1cc(Cl)sc12.ClCCCl.NCCO.O=C([O-])O.[Na+].[Na+]>>Cc1nn(-c2c(F)cccc2CNCCO)cc1CN1CCC2(CC1)OCC(F)(F)c1cc(Cl)sc12",
        "output": "468"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(Cl)Cl.ClCCl.O=S(=O)(NCC1Cc2ccccc2C1)c1ccc(Cl)cc1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=Cc1ccc2c(c1)CC(CNS(=O)(=O)c1ccc(Cl)cc1)C2",
        "output": "591"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)c1cc2cc(c1)OCCSc1cccc(c1)Nc1nc(ncc1Cl)N2.[Na+].[OH-]>>O=C(O)c1cc2cc(c1)OCCSc1cccc(c1)Nc1nc(ncc1Cl)N2",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCNCC(O)(CNc1cc(C)cc2c1cnn2-c1ccc(F)cc1)C(F)(F)F.Cc1ccccc1C(=O)O>>CCN(CC(O)(CNc1cc(C)cc2c1cnn2-c1ccc(F)cc1)C(F)(F)F)C(=O)c1ccccc1C",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Br.CC(=O)O.COc1cccc(-c2nc3ccsc3c(=O)[nH]2)c1>>O=c1[nH]c(-c2cccc(O)c2)nc2ccsc12",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccccn1.CC(C)(C)OC(=O)N1CCC(O)CC1.CCCCCC.CS(C)=O.O.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCC(Oc2ccccn2)CC1",
        "output": "551"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CCC(O)(c1ccc(O)cc1)c1cccc(C(F)(F)F)c1.CCN(CC)C(=O)CCl.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CCN(CC)C(=O)COc1ccc(C(O)(CC)c2cccc(C(F)(F)F)c2)cc1",
        "output": "458"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.FCCCc1ccc(Nc2nc(Cl)ncc2F)cc1.Nc1ccc(S(N)(=O)=O)cc1.O=C(O)C(F)(F)F>>NS(=O)(=O)c1ccc(Nc2ncc(F)c(Nc3ccc(CCCF)cc3)n2)cc1",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NC1(C(=O)NCc2ccc(Nc3ccccc3C(F)(F)F)cn2)CCCCC1.O=C(O)c1cncnc1>>O=C(NC1(C(=O)NCc2ccc(Nc3ccccc3C(F)(F)F)cn2)CCCCC1)c1cncnc1",
        "output": "989"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCc1cc(C(=O)OCC)c2cnn(C(C)C)c2n1.CCO.[Na+].[OH-]>>CCCc1cc(C(=O)O)c2cnn(C(C)C)c2n1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOCCC(=N)NO.CCc1ccc(C2CC(C(=O)O)CN(C(=O)N3CCSCC3)C2)cc1>>CCOCCc1noc(C2CC(c3ccc(CC)cc3)CN(C(=O)N3CCSCC3)C2)n1",
        "output": "924"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CCCN.COc1cc2nc(Cl)nc(NC3CCN(Cc4c(OCCN(C)C)cccc4N(C)C)CC3)c2cc1OC>>CCN(CC)CCCNc1nc(NC2CCN(Cc3c(OCCN(C)C)cccc3N(C)C)CC2)c2cc(OC)c(OC)cc2n1",
        "output": "544"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN1CCOCC1.Cl.O=C(O)CN1C(=O)C(=Cc2ccc(OCCc3ccccc3)c(OCc3ccccc3)c2)SC1=S.On1nnc2cccnc21.[Cl-].[NH4+]>>NC(=O)CN1C(=O)C(=Cc2ccc(OCCc3ccccc3)c(OCc3ccccc3)c2)SC1=S",
        "output": "313"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.O=C(O)CCCCCCCCCCCBr.Oc1ccc(F)cc1.[H-].[Na+]>>O=C(O)CCCCCCCCCCCOc1ccc(F)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "NCC(c1ccc(Cl)cc1)C1CCOCC1.O=C(O)c1c(F)cccc1Cl>>O=C(NCC(c1ccc(Cl)cc1)C1CCOCC1)c1c(F)cccc1Cl",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOCC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[N-]=[N+]=NC1CCC2=C(C1)c1ccccc1Oc1ccccc12>>NC1CCC2=C(C1)c1ccccc1Oc1ccccc12",
        "output": "89"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COc1cc(OCc2ccccc2)ccc1-c1nc(C)c(-c2cccnc2)[nH]1.[H][H].[Pd]>>COc1cc(O)ccc1-c1nc(C)c(-c2cccnc2)[nH]1",
        "output": "23"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCCCCC.CCOC(C)=O.CN(C)C=O.O.Oc1ccc(O)cc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1ccc(O)cc1",
        "output": "746"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)CN(c1ccccc1C(F)(F)F)S(=O)(=O)c1ccc(Br)cc1.CS(=O)(=O)c1ccc(B(O)O)cc1.Cl[Pd]Cl.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)CN(c1ccccc1C(F)(F)F)S(=O)(=O)c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCOC(=S)c1cnc(C)nc1Cl.Nc1ccc(F)cc1>>CCOC(=S)c1cnc(C)nc1Nc1ccc(F)cc1",
        "output": "161"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCCOc1ccn2nccc2c1.c1cc2c(c(N3CCNCC3)c1)OCCC2>>c1cc2c(c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)c1)OCCC2",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CN.N#Cc1cnc2cnc(F)cc2c1Nc1cccc(Br)c1>>CNc1cc2c(Nc3cccc(Br)c3)c(C#N)cnc2cn1",
        "output": "810"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Cc1cc2c(c3ccc(=O)[nH]c13)OC(C(O)COS(C)(=O)=O)C2.[N-]=[N+]=[N-].[Na+]>>Cc1cc2c(c3ccc(=O)[nH]c13)OC(C(O)CN=[N+]=[N-])C2",
        "output": "322"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.COC(=O)Cl.ClCCl.Nc1ccc(N2CCOCC2)cc1>>COC(=O)Nc1ccc(N2CCOCC2)cc1",
        "output": "102"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C[C@@H]1CN(c2ccc([N+](=O)[O-])cc2F)[C@@H](C)CN1.C[C@H]1CNC[C@@H](C)N1.O=[N+]([O-])c1ccc(F)cc1>>C[C@@H]1CN(c2ccc([N+](=O)[O-])cc2)C[C@H](C)N1",
        "output": "26"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)c1cn(CC(F)CCn2ccc(NC(=O)Cc3ccccc3)cc2=O)nn1.CO.[Li+].[OH-]>>O=C(Cc1ccccc1)Nc1ccn(CCC(F)Cn2cc(C(=O)O)nn2)c(=O)c1",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)CCN(C)c1ccccc1.CCO.Cl.NO.O.O=C([O-])[O-].[Na+].[Na+]>>CC(CCN(C)c1ccccc1)=NO",
        "output": "86"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)Cc2cc(Br)ccc2O1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)Cc2cc(B3OC(C)(C)C(C)(C)O3)ccc2O1",
        "output": "942"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(C2CCC(O)CC2NC(=O)c2ccc(OCC3CC3)c(OCC3CC3)c2)cc1OC.ClCCl.[Cr+3].[Cr+3].[O-2].[O-2].[O-2].c1ccncc1>>COc1ccc(C2CCC(=O)CC2NC(=O)c2ccc(OCC3CC3)c(OCC3CC3)c2)cc1OC",
        "output": "87"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.COc1ccc([N+](=O)[O-])cc1C(=O)O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cc([N+](=O)[O-])ccc1OC",
        "output": "415"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCC(CCC)c1ccccc1.COC(Cl)Cl.ClC(Cl)Cl.Cl[Ti](Cl)(Cl)Cl>>CCCC(CCC)c1ccc(C=O)cc1",
        "output": "591"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=[N+]=[N-].CC(=O)SCCC(=O)N1CC(=O)C[C@H]1C(=O)O.CCOCC>>COC(=O)[C@@H]1CC(=O)CN1C(=O)CCSC(C)=O",
        "output": "60"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C(=O)NC(C(=O)N1CC(O)CC1C(=O)c1c[nH]c2cc(F)ccc12)C(C)(C)C)N(C)C(=O)OCc1ccccc1.CO.[H][H].[Pd]>>CNC(C)C(=O)NC(C(=O)N1CC(O)CC1C(=O)c1c[nH]c2cc(F)ccc12)C(C)(C)C",
        "output": "568"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)n1nc(-c2ccc(O)cc2)c(C#N)c1N.CCOC(=O)c1nc(N2CCc3cccc(C(=O)N(COCC[Si](C)(C)C)c4nc5ccccc5s4)c3C2)sc1-c1ccc(COc2ccc(-c3nn(C(=O)OC(C)(C)C)c(N)c3C#N)cc2)cc1.CN(C)CCO.Oc1ccc(OCc2ccccc2)cc1>>CN(C)CCOc1ccc(OCc2ccccc2)cc1",
        "output": "550"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "N.N[C@@H]1c2ccccc2C[C@H]1O.O=C(Cl)c1ccccc1>>O=C(N[C@@H]1c2ccccc2C[C@H]1O)c1ccccc1",
        "output": "411"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(=O)CC1.Nc1ccc(Cl)cc1>>CC(C)(C)OC(=O)N1CCC(Nc2ccc(Cl)cc2)CC1",
        "output": "469"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.[OH-].[OH-].[Pd+2].c1ccc(CN2CCO[C@@H]3COC[C@H]32)cc1>>C1CO[C@@H]2COC[C@H]2N1",
        "output": "84"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCc1c[nH]cc1C(=O)OC.O=C1CCC(=O)N1Br.c1ccncc1>>CCCc1c(C(=O)OC)c[nH]c1Br",
        "output": "779"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1noc(-c2ccc(Br)cc2)c1CN1CCC(c2ccccc2)CC1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4CN4CCC(c5ccccc5)CC4)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(Oc1ccc(Cl)cc1C=O)C(=O)OC.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.OCCO>>CCC(Oc1ccc(Cl)cc1C1OCCO1)C(=O)OC",
        "output": "117"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCCCc1ccc(OCC(O[Si](C)(C)C(C)(C)C)c2nc(C(=O)OC)cs2)cc1.CO.Cl>>CCCCCCCCc1ccc(OCC(O)c2nc(C(=O)OC)cs2)cc1",
        "output": "708"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CNOC.Cl.O.O.O=C(O)c1ccc(F)c(F)c1.On1nnc2ccccc21>>CON(C)C(=O)c1ccc(F)c(F)c1",
        "output": "828"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COc1ccc(C(=O)N(C[C@H]2CN(C(=O)OC(C)(C)C)C[C@@H]2Cc2ccccc2)C(C)C)cc1OCCOCc1ccccc1.[OH-].[OH-].[Pd+2]>>COc1ccc(C(=O)N(C[C@H]2CN(C(=O)OC(C)(C)C)C[C@@H]2Cc2ccccc2)C(C)C)cc1OCCO",
        "output": "178"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCc1ccc(C2CNCC(C(=O)OC)C2)cc1.O=C(Cl)N1CCOCC1>>CCc1ccc(C2CC(C(=O)OC)CN(C(=O)N3CCOCC3)C2)cc1",
        "output": "258"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(Oc1ccc(Oc2ncc(Cl)cc2Cl)cc1)C(=O)O.CN(C)C=O.ClC(Cl)Cl.O=S(Cl)Cl>>CC(Oc1ccc(Oc2ncc(Cl)cc2Cl)cc1)C(=O)Cl",
        "output": "53"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(S(=O)(=O)c2cnc3ccccc3c2O)cc1.O=P(Cl)(Cl)Cl>>Cc1ccc(S(=O)(=O)c2cnc3ccccc3c2Cl)cc1",
        "output": "177"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COc1cc(OC)c2c(=O)cc(-c3cccc(C)c3Cl)oc2c1[C@@H]1CCN(C)[C@H]1CO.Cl.O=C([O-])[O-].[Na+].[Na+].c1ccncc1>>Cc1cccc(-c2cc(=O)c3c(O)cc(O)c([C@@H]4CCN(C)[C@H]4CO)c3o2)c1Cl",
        "output": "20"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCO.O=[N+]([O-])c1cccc(-c2cnccn2)c1.[Pd]>>Nc1cccc(-c2cnccn2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=O.O=C1S/C(=C\\c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)C(=O)N1[C@@H]1CCNC[C@H]1F>>CN1CC[C@@H](N2C(=O)S/C(=C\\c3ccc4c(cnn4Cc4ccc(Cl)cc4C(F)(F)F)c3)C2=O)[C@H](F)C1",
        "output": "217"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "N.Nc1ccccc1N.O.O=C(O)CCCCC1CCCCC1>>c1ccc2[nH]c(CCCCC3CCCCC3)nc2c1",
        "output": "512"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCCBr.CCCCCc1cc(OC2CCNCC2)c2ncccc2c1.CCCCc1cc(OC2CCN(CCCNC(=O)OC(C)(C)C)CC2)c2ncccc2c1>>CCCCCc1cc(OC2CCN(CCCNC(=O)OC(C)(C)C)CC2)c2ncccc2c1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C(O)c1cc[n+]([O-])cc1.O=P(Cl)(Cl)Cl.[P]>>O=C(O)c1ccnc(Cl)c1",
        "output": "2"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "B.CC(=O)O.CC(C)(C)OC(=O)N1CCC(=O)N(CCC=O)CC1.CCO.Cl.ClCCCl.OC1CNCCC12CC2.c1ccncc1>>CC(C)(C)OC(=O)N1CCC(=O)N(CCCN2CCC3(CC3)C(O)C2)CC1",
        "output": "484"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)OCCOc1nc(Cl)c(Cl)cc1C#N.OB1OCc2cc(O)cc(F)c21>>CC(C)OCCOc1nc(Oc2cc(F)c3c(c2)COB3O)c(Cl)cc1C#N",
        "output": "516"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CC=C(c2ccc([N+](=O)[O-])cc2)CC1.CC(C)C(=O)Nc1cccc(C2CCNCC2)c1.Cl>>O=[N+]([O-])c1ccc(C2=CCNCC2)cc1",
        "output": "800"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1CCN(c2cccc(Br)c2)CC1.CS(=O)(=O)c1ccccc1-c1cccn2nc(N)nc12.c1ccc(P(C2CCCCC2)C2CCCCC2)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c1>>CN1CCN(c2cccc(Nc3nc4c(-c5ccccc5S(C)(=O)=O)cccn4n3)c2)CC1",
        "output": "970"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)C1CC=C(c2ccc3c(CC)nn(-c4ccc(F)cc4)c3c2)CC1.CO.[Na+].[OH-]>>CCc1nn(-c2ccc(F)cc2)c2cc(C3=CCC(C(=O)O)CC3)ccc12",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1[nH]c2cc(Cl)cc(Cl)c2c1NS(=O)(=O)c1ccccc1.Cl.O.O.[Li+].[OH-]>>O=C(O)c1[nH]c2cc(Cl)cc(Cl)c2c1NS(=O)(=O)c1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCC(=O)Nc1cccc(C2CCN(CCCN)CC2)c1.O=C(O)C1(c2ccc(Cl)cc2)CCCC1>>CCCC(=O)Nc1cccc(C2CCN(CCCNC(=O)C3(c4ccc(Cl)cc4)CCCC3)CC2)c1",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1n[nH]c2ncc(Br)cc12.Cl.[Na+].[OH-]>>O=C(O)c1n[nH]c2ncc(Br)cc12",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.COc1cc(Br)c(F)cc1N.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[C-]#N.[C-]#N.[Pd].[Pd].[Zn+2]>>COc1cc(C#N)c(F)cc1N",
        "output": "65"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CCOC(=O)COc1ncccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1[N+](=O)[O-].O.[Fe]>>CCOC(=O)COc1ncccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1N",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)COc1ccc(SCc2ccc(OCc3ccc(Cl)cc3Cl)cc2)c2c1CCC2.[Br-].[K+]>>O=C(O)COc1ccc(SCc2ccc(OCc3ccc(Cl)cc3Cl)cc2)c2c1CCC2",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#CCCCC#N.CCCC[N+](CCCC)(CCCC)CCCC.O=C(NOCc1cccc(I)c1)c1ccccc1NCc1ccncc1.[I-]>>N#CCCCC#Cc1cccc(CONC(=O)c2ccccc2NCc2ccncc2)c1",
        "output": "664"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CS(=O)(=O)N1CCc2c(c(-c3ccc(C(F)(F)F)cc3)nn2CCC=O)C1.ClCCl.O=C([O-])O.O=[N+]([O-])c1ccccc1N1CCNCC1.[Na+].[Na+]>>CS(=O)(=O)N1CCc2c(c(-c3ccc(C(F)(F)F)cc3)nn2CCCN2CCN(c3ccccc3[N+](=O)[O-])CC2)C1",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)Cc1cccc(N(C(=O)c2ccccc2)c2ccccc2)c1.[Na+].[OH-]>>O=C(O)Cc1cccc(N(C(=O)c2ccccc2)c2ccccc2)c1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cn1c(N2CCOCC2)nc(-c2nc(Cc3ccc(F)cc3)no2)c(OCc2ccccc2)c1=O.O=C(O)C(F)(F)F>>Cn1c(N2CCOCC2)nc(-c2nc(Cc3ccc(F)cc3)no2)c(O)c1=O",
        "output": "492"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCc1ccccc1.O.O=C(CC1CCCc2cc(O)ccc21)N(Cc1ccccc1)CC1CC=CC1.O=C([O-])[O-].[K+].[K+]>>O=C(CC1CCCc2cc(OCc3ccccc3)ccc21)N(Cc1ccccc1)CC1CC=CC1",
        "output": "127"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNC1.CC(=O)O.ClCCl.Cn1cc(-c2cccc(C3(C=O)CCN(c4ncnc5[nH]cnc45)CC3)c2)cn1.[BH4-].[Na+]>>Cn1cc(-c2cccc(C3(CN4CCCC4)CCN(c4ncnc5[nH]cnc45)CC3)c2)cn1",
        "output": "484"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1CNc2ccccc21.CCN(CC)CC.ClC(Cl)Cl.O=C(Cl)CCl>>CC1CN(C(=O)CCl)c2ccccc21",
        "output": "160"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1cccc(Br)n1.CC(C)O>>CC(C)Oc1cccc(Br)n1",
        "output": "551"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)CCc1cc(OCc2ccc(-c3cc(OC)ccc3F)c(CC(C)(C)C)n2)ccc1OC.CO.Cl.O.[Na+].[OH-]>>COc1ccc(F)c(-c2ccc(COc3ccc(OC)c(CCC(=O)O)c3)nc2CC(C)(C)C)c1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOCC.CCc1cc([N+](=O)[O-])c(O)cc1F.CI.CS(C)=O.O.O=C([O-])[O-].[K+].[K+]>>CCc1cc([N+](=O)[O-])c(OC)cc1F",
        "output": "62"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1nn(-c2ccccc2)cc1[N+](=O)[O-].Cl.O.[Na+].[OH-]>>O=C(O)c1nn(-c2ccccc2)cc1[N+](=O)[O-]",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(NC1CC1)c1ccc(C#C[Si](C)(C)C)cc1.CO.O=C([O-])[O-].[K+].[K+]>>C#Cc1ccc(C(C)NC2CC2)cc1",
        "output": "337"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccccc1C(=O)O.NCC1(c2ccc(C(F)(F)F)nc2)CCC(F)(F)CC1>>Cc1ccccc1C(=O)NCC1(c2ccc(C(F)(F)F)nc2)CCC(F)(F)CC1",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Nc1cc(CN2CCOCC2)cc(Nc2ncc3cc(Br)ccc3n2)c1.CC1(C)OB(c2cn[nH]c2)OC1(C)C.COCCOC.ClCCl.O=C([O-])[O-].[Na+].[Na+]>>CC(=O)Nc1cc(CN2CCOCC2)cc(Nc2ncc3cc(-c4cn[nH]c4)ccc3n2)c1",
        "output": "971"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.CN(CCO)C(=O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-]>>CC(=O)OCCN(C)C(=O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-]",
        "output": "126"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.O=CN1CCNCC1>>CS(=O)(=O)N1CCN(C=O)CC1",
        "output": "584"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc2c3c(c(=O)oc2c1)CNCC3.O.O=S(=O)(O)O.O=[N+]([O-])O.[NH4+].[OH-]>>COc1cc2oc(=O)c3c(c2cc1[N+](=O)[O-])CCNC3",
        "output": "21"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(Cc1ccc(OCc2sc(-c3cccc(OC)c3)nc2C)cc1C)OCC.[Li+].[OH-]>>CCOC(Cc1ccc(OCc2sc(-c3cccc(OC)c3)nc2C)cc1C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.FC(F)(F)Oc1cc(CBr)ccc1Br.O.O=C([O-])O.[C-]#N.[K+].[Na+]>>N#CCc1ccc(Br)c(OC(F)(F)F)c1",
        "output": "39"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCOC(=O)CCc1ccc(Br)nc1.CS(=O)(=O)Cl.ClCCl.OB(O)c1ccc(F)cc1.OCCCc1ccc(-c2ccc(F)cc2)nc1>>CS(=O)(=O)OCCCc1ccc(-c2ccc(F)cc2)nc1",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCCOc1ccc(F)cc1>>CS(=O)(=O)OCCOc1ccc(F)cc1",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C[C@H]1CN(S(C)(=O)=O)Cc2nc3cnc4ccccc4c3n21.ClCCl.O=C(OO)c1cccc(Cl)c1.O=C([O-])[O-].[Na+].[Na+]>>C[C@H]1CN(S(C)(=O)=O)Cc2nc3c[n+]([O-])c4ccccc4c3n21",
        "output": "820"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Nc1cc2nc(-c3ccccc3)cn2cc1C1CC1.ClCCl.O=C(O)C(F)(F)F>>Nc1cc2nc(-c3ccccc3)cn2cc1C1CC1",
        "output": "782"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(Cc1ccnc(NC(=O)OC(C)(C)C)c1)Oc1ccc([N+](=O)[O-])c2ccccc12.CO.[H][H].[Pt]>>CC(Cc1ccnc(NC(=O)OC(C)(C)C)c1)Oc1ccc(N)c2ccccc12",
        "output": "202"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Cl.CCN(C(C)C)C(C)C.CN(C)c1ccncc1.ClCCl.NC(c1ccc2ccc(-c3ccccc3)nc2c1)c1nccnc1Cl.O>>CC(=O)NC(c1ccc2ccc(-c3ccccc3)nc2c1)c1nccnc1Cl",
        "output": "206"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CC[C@H](N)C1.ClCCl.O=Cc1ccccc1-c1ccccc1.O=S(=O)([O-])[O-].[Mg+2].[Na+]>>CC(C)(C)OC(=O)N1CC[C@H](NCc2ccccc2-c2ccccc2)C1",
        "output": "468"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)CCC#Cc1cccc2c1/C(=C/c1[nH]ccc1OC)C(=O)N2.O.O.[Li]O>>COc1cc[nH]c1/C=C1\\C(=O)Nc2cccc(C#CCCC(=O)O)c21",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.O.O=C(NCC(=O)N1CCNCC1)c1ccc(-c2ccccc2)cc1.O=C(O)c1ccnc(Cl)c1.On1nnc2ccccc21>>O=C(NCC(=O)N1CCN(C(=O)c2ccnc(Cl)c2)CC1)c1ccc(-c2ccccc2)cc1",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)NCCc1ccccc1.ClCCl.O=S(=O)(O)Cl>>CC(=O)NCCc1ccc(S(=O)(=O)Cl)cc1",
        "output": "182"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C(C)(C)C(O)/C(C)=C/Cc1c(O)c2c(c(C)c1OC)COC2=O.CCOC(C)=O.CCOCC>>COc1c(C)c2c(c(O)c1C/C=C(\\C)C(O)C(C)(C)C(=O)O)C(=O)OC2",
        "output": "281"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CCO.O=[N+]([O-])c1cccc2[nH]ccc12.[Fe]>>Nc1cccc2[nH]ccc12",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CI.CN(C)C=O.COc1cc(C(=O)N2CCC3(CC2)Oc2ccccc2-n2cccc23)ccc1C(C)(C)O.[H-].[Na+]>>COc1cc(C(=O)N2CCC3(CC2)Oc2ccccc2-n2cccc23)ccc1C(C)(C)OC",
        "output": "140"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCOC(C)=O.CN(C)C=O.O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl.Oc1ccc(-c2cc(=S)ss2)cc1.Oc1cccc2[nH]nnc12>>O=C(Cc1ccccc1Nc1c(Cl)cccc1Cl)Oc1ccc(-c2cc(=S)ss2)cc1",
        "output": "108"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1.O=C(Cl)N1CCCC1>>CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)N5CCCC5)CC4)cn3)nc2n1C1CCCC1",
        "output": "258"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cc(Cl)ccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(Oc2cccc(C(=O)O)c2)c(F)c1.Cl.NO.O=C([O-])O.[Na+]>>Cc1cc(Cl)ccc1C(C/C(=N\\O)c1ccc(=O)n(C)c1)c1ccc(Oc2cccc(C(=O)O)c2)c(F)c1",
        "output": "966"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCCCCOC1=C(c2ccccc2)C(CCC(=O)OCC)OC1=O.Cl.O>>CCCCCOC1=C(c2ccccc2)C(CCC(=O)O)OC1=O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)O.CCOC(C)=O.CN(C)C=O.Cn1nnn(-c2cc([N+](=O)[O-])ccc2F)c1=O.O.[H-].[Na+]>>CC(C)Oc1ccc([N+](=O)[O-])cc1-n1nnn(C)c1=O",
        "output": "485"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN(C)C=O.CS(=O)(=O)c1ccc(Nc2ncnc(OC3CCNCC3)c2[N+](=O)[O-])cc1.O=S(=O)(Cl)c1cccs1>>CS(=O)(=O)c1ccc(Nc2ncnc(OC3CCN(S(=O)(=O)c4cccs4)CC3)c2[N+](=O)[O-])cc1",
        "output": "798"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1ccc2oc(-c3ccc(C(N)=O)nc3)cc2c1.ClCCl.O.O=C([O-])O.[Na+]>>NC(=O)c1ccc(-c2cc3cc(O)ccc3o2)cn1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COc1ccc2cc([C@H]3[C@@H]4CC[C@@H](C4)[C@@H]3CN(C)C)ccc2c1.O>>CN(C)C[C@H]1[C@H]2CC[C@H](C2)[C@@H]1c1ccc2cc(O)ccc2c1",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cn(-c2cccc(Br)c2)c2ncccc2c1=O.Cl.O.OCC1CCCO1.[Na+].[OH-]>>O=C(O)c1cn(-c2cccc(Br)c2)c2ncccc2c1=O",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1sc(CCc2conc2-c2ccccn2)nc1C.O.O.[Li+].[OH-]>>Cc1nc(CCc2conc2-c2ccccn2)sc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.C[C@H](CCO)C1CCN(C(=O)OC(C)(C)C)CC1.ClCCl>>C[C@H](CCOS(C)(=O)=O)C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N(Cc1cc2c(cn1)OCCO2)C1CCNCC1.CO.ClC(Cl)Cl.ClCCl.O=C([O-])O.O=CCn1c(=O)cnc2ccc(-n3cncn3)nc21.[BH3-]C#N.[Na+].[Na+]>>CC(C)(C)OC(=O)N(Cc1cc2c(cn1)OCCO2)C1CCN(CCn2c(=O)cnc3ccc(-n4cncn4)nc32)CC1",
        "output": "484"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCC.CCCCCCCCCCO.CS(=O)(=O)Cl.Cc1cc(C)nc(C)c1>>CCCCCCCCCCOS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCI.CN(C)C=O.COc1ccc(-c2cc(=Nc3c(C)cc(C)cc3C)n(C)c(=O)[nH]2)cc1OC.O.[K+].[OH-]>>CCn1c(-c2ccc(OC)c(OC)c2)cc(=Nc2c(C)cc(C)cc2C)n(C)c1=O",
        "output": "326"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1nc(N2CCNCC2)c(C#N)c(C)c1Cl.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)/C=C/C(F)(F)F>>Cc1nc(N2CCN(C(=O)/C=C/C(F)(F)F)CC2)c(C#N)c(C)c1Cl",
        "output": "870"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(Nc2cc3ccccc3c(Cl)n2)n[nH]1.Cc1cccc(B(O)O)c1>>Cc1cccc(-c2nc(Nc3cc(C)[nH]n3)cc3ccccc23)c1",
        "output": "865"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.COc1ccc(C)c(Cl)c1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COc1ccc(CBr)c(Cl)c1",
        "output": "29"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C=CC(=O)Cl.CO.Cl.ClCCl.O=C(Nc1nc2ccccc2n1C1CCNCC1)c1ccc(Cl)cc1>>C=CC(=O)N1CCC(n2c(NC(=O)c3ccc(Cl)cc3)nc3ccccc32)CC1",
        "output": "135"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(c2ccc(C(C)C)cc2)=CC(C)(C)O3)cc1.Cl.[Na+].[OH-]>>CC(C)c1ccc(C2=CC(C)(C)Oc3ccc(C#Cc4ccc(C(=O)O)cc4)cc32)cc1",
        "output": "5"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.CC(=O)O.COc1ccc(CCN)cc1OC>>COc1cc(Br)c(CCN)cc1OC",
        "output": "98"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C(=C1CCNCC1)c1cccc(OCc2ccccc2)c1.O=C(Nc1cccnc1)Oc1ccccc1.O=C(O)C(F)(F)F>>O=C(Nc1cccnc1)N1CCC(=Cc2cccc(OCc3ccccc3)c2)CC1",
        "output": "525"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CC(N2CCNCC2)C1.CCN(C(C)C)C(C)C.CCOC(C)=O.Cl.Cl.Clc1cc(Cl)ncn1.O>>Clc1cc(N2CCN(C3CCC3)CC2)ncn1",
        "output": "162"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)[C@@H]1CC(=O)N(c2ccc(OCc3c(F)cccc3F)cc2)C1>>CNC(=O)[C@@H]1CC(=O)N(c2ccc(OCc3c(F)cccc3F)cc2)C1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)C1(N)CCN(Cc2ccccc2)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NC1(CO)CCN(Cc2ccccc2)CC1",
        "output": "343"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.NC(=O)c1ccc(Oc2ccc(C=O)cc2)nc1.O=C(O)/C=C/C(=O)O.[Na+].c1ccc(C2CCCCNC2)cc1>>NC(=O)c1ccc(Oc2ccc(CN3CCCCC(c4ccccc4)C3)cc2)nc1",
        "output": "567"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NC1=N[C@](C)(c2cc(NC(=O)OC(C)(C)C)ccc2F)Cn2c(CO)cnc21.ClCCl.[Mn+4].[O-2].[O-2]>>CC(C)(C)OC(=O)NC1=N[C@](C)(c2cc(NC(=O)OC(C)(C)C)ccc2F)Cn2c(C=O)cnc21",
        "output": "287"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCN(C(C)C)C(C)C.COc1ccc(CO)cc1.CS(=O)(=O)Cl>>COc1ccc(COS(C)(=O)=O)cc1",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COC(=O)c1cc2c(s1)-c1ccc(Br)cc1OCC2.Cl.ClCCCl.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)CCCOc1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C1CCCOc2ccccc21",
        "output": "274"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)[C@@H]1CC[C@H](C(=O)OCC)N1Cc1ccccc1.NCc1ccccc1>>CCOC(=O)[C@H]1CC[C@@H](C(=O)O)N1Cc1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)C[C@@H]1CC[C@@H](c2ccc(NC(=O)c3nnc(NC(=O)c4ccc(Cl)cc4)o3)cc2)CC1.Cl.O.[Li+].[OH-]>>O=C(O)C[C@@H]1CC[C@@H](c2ccc(NC(=O)c3nnc(NC(=O)c4ccc(Cl)cc4)o3)cc2)CC1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)COc1cc(C=O)ccc1OC.COCCc1nc2c(N)nc3ccccc3c2n1CCCN>>CCOC(=O)COc1cc(CNCCCn2c(CCOC)nc3c(N)nc4ccccc4c32)ccc1OC",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(Cl)Cl.CCCCCC(=O)Cl.CO.Cl.OC1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)C1>>CCCCCC(=O)OC1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)C1",
        "output": "126"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN.CCN.COC(=O)Cc1cc(-c2ccc(-c3cccc(S(C)(=O)=O)c3)s2)n(-c2ccccc2Cl)n1.Cl>>CCNC(=O)Cc1cc(-c2ccc(-c3cccc(S(C)(=O)=O)c3)s2)n(-c2ccccc2Cl)n1",
        "output": "392"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1CNC(C(C)(C)O)CO1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cc(C(=O)O)cn2nc(NCc3cccc(Cl)c3)nc12.F[P-](F)(F)(F)(F)F>>COc1cc(C(=O)N2CC(C)OCC2C(C)(C)O)cn2nc(NCc3cccc(Cl)c3)nc12",
        "output": "256"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cl.O=C(O)c1ccc(Cl)cc1O.O=C([O-])O.[Na+]>>COC(=O)c1ccc(Cl)cc1O",
        "output": "33"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrBr.CC(=O)N1c2cccc(C(F)(F)F)c2CC1C.CC(=O)O.O=C([O-])O.[Na+]>>CC(=O)N1c2ccc(Br)c(C(F)(F)F)c2CC1C",
        "output": "98"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.NCCc1ccc(-c2ccc(Cl)c(Cl)c2)o1.O=C(O)c1c[nH]cn1>>O=C(NCCc1ccc(-c2ccc(Cl)c(Cl)c2)o1)c1c[nH]cn1",
        "output": "697"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CN(C)c1ccc(C=O)cc1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-].[Li]CCCC>>C=Cc1ccc(N(C)C)cc1",
        "output": "649"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCOc1c(C(=CC=CC(C)=CC(=O)OCC)CC)cc(C(C)C)cc1C(C)C.CCO.Cl.[Na+].[OH-]>>CCCOc1c(C(=CC=CC(C)=CC(=O)O)CC)cc(C(C)C)cc1C(C)C",
        "output": "122"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C1C2CN(Cc3ccccc3)CC21.CO.[OH-].[OH-].[Pd+2]>>CN(C)C1C2CNCC21",
        "output": "84"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NCC1CCCN1C(=O)c1ccc(C(=O)NC(Cc2ccccn2)c2nc3cc(Cl)ccc3[nH]2)cc1Cl.CO.ClCCl.ClCl.N.O=C(O)C(F)(F)F>>NCC1CCCN1C(=O)c1ccc(C(=O)NC(Cc2ccccn2)c2nc3cc(Cl)ccc3[nH]2)cc1Cl",
        "output": "538"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(C#N)c2)cc1-c1cccc(F)c1F.ClCCl.O=C(O)C(F)(F)F>>CN(C)c1cc2c(cc1-c1cccc(F)c1F)NC(=O)CC(c1cccc(C#N)c1)=N2",
        "output": "930"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COC(=O)c1ccc2cc(-c3ccc(OCc4c(-c5c(Cl)cccc5Cl)noc4C4CCC4)cc3)ccc2n1.Cl.[Na+].[OH-]>>O=C(O)c1ccc2cc(-c3ccc(OCc4c(-c5c(Cl)cccc5Cl)noc4C4CCC4)cc3)ccc2n1",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(c1ccccc1C(F)(F)F)S(=O)(=O)Cl.CCOC(=O)CCc1ccc(S(=O)(=O)CCc2c(CCN)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1>>CCOC(=O)CCc1ccc(S(=O)(=O)CCc2c(CCNS(=O)(=O)C(C)c3ccccc3C(F)(F)F)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1",
        "output": "493"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1c(Cl)nnc(Cl)c1C.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>Cc1c(Cl)nnc(Cl)c1CBr",
        "output": "625"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "NC[C@H]1CC[C@@H](OCc2ccccc2)CC1.O=C(O)c1cn[nH]c1>>O=C(NC[C@H]1CC[C@@H](OCc2ccccc2)CC1)c1cn[nH]c1",
        "output": "621"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(NC(=O)c1ccc2cncc(Br)c2n1)C(C)(C)O.OB(O)c1ccc(Cl)cc1Cl>>CC(NC(=O)c1ccc2cncc(-c3ccc(Cl)cc3Cl)c2n1)C(C)(C)O",
        "output": "871"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.NCc1ccccc1.Nc1nc(Cl)ncc1-c1nnn[nH]1>>Nc1nc(NCc2ccccc2)ncc1-c1nnn[nH]1",
        "output": "364"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)C(=O)c1cn(Cc2ccccc2)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc12.Cl.O.[K+].[OH-]>>O=C(O)C(=O)c1cn(Cc2ccccc2)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc12",
        "output": "472"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)C(Nc1ccc(C(=N)NO)cc1)c1cc(OCC)cc(OCC)c1F.Cl.[Na+].[OH-]>>CCOc1cc(OCC)c(F)c(C(Nc2ccc(C(=N)NO)cc2)C(=O)O)c1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC12CC3CC(C1)C(C#N)C(C3)C2.Cl>>N#CC1C2CC3CC1CC(N)(C3)C2",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCN[C@@H]1CNCC[C@H]1NC(=O)c1nc(Cl)c(CC)[nH]1.CCOC(=O)c1sc(Br)nc1C.O=C([O-])[O-].[Na+].[Na+]>>CCCN[C@@H]1CN(c2nc(C)c(C(=O)OCC)s2)CC[C@H]1NC(=O)c1nc(Cl)c(CC)[nH]1",
        "output": "657"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(COCc1ccccc1)Nc1cc2c(cc1Br)C(=O)CC2.[C-]#N.[C-]#N.[Fe+2].[Pd].[Pd].[Zn+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>N#Cc1cc2c(cc1NC(=O)COCc1ccccc1)CCC2=O",
        "output": "65"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1cc(N)c(F)cc1Br.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[K+].[Pd].[Pd]>>Cc1cc(N)c(F)cc1B1OC(C)(C)C(C)(C)O1",
        "output": "942"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCCC.CC(=O)[O-].CC(=O)[O-].CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.COC(=O)CCn1c(=O)c2cc(I)ccc2n(Cc2cn(C(=O)NC(C)(C)C)c3ccccc23)c1=O.O=C([O-])[O-].[Br-].[K+].[K+].[Pd+2]>>CCCC=Cc1ccc2c(c1)c(=O)n(CCC(=O)OC)c(=O)n2Cc1cn(C(=O)NC(C)(C)C)c2ccccc12",
        "output": "725"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(C)N.CCN(CC)CC.CO.COc1cc2ncnc(Oc3ccc(N)c(F)c3)c2cc1OC.ClC(Cl)Cl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCC(C)NC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1F",
        "output": "913"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(-c2ccc(Cl)cn2)cc(-n2nnnc2C(C)C)c1.O.[Li+].[OH-]>>CC(C)c1nnnn1-c1cc(C(=O)O)cc(-c2ccc(Cl)cn2)c1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(-c2cccnc2C#N)cc1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>N#Cc1ncccc1-c1ccc(CBr)cc1",
        "output": "29"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.O=c1cc(OCc2cccs2)ccn1CCc1ccc(CO)cc1>>O=c1cc(OCc2cccs2)ccn1CCc1ccc(CN2CCCC2)cc1",
        "output": "765"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CS(=O)(=O)C1Cc2cc(Cl)ccc2C1O.ClCCl.c1ccncc1>>CC(=O)OC1c2ccc(Cl)cc2CC1S(C)(=O)=O",
        "output": "254"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N)c(-c3cc(C(=O)NC4(c5ccccc5)CC4)ccc3C)cc12.CO.CS(=O)(=O)Cl.ClCCCl.c1ccncc1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(NS(C)(=O)=O)c(-c3cc(C(=O)NC4(c5ccccc5)CC4)ccc3C)cc12",
        "output": "194"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cccc(S(=O)(=O)Cl)c1.Nc1ccccc1N>>Cc1cccc(S(=O)(=O)Nc2ccccc2N)c1",
        "output": "68"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(N)CCC1.CCN(C(C)C)C(C)C.CCOC(=O)N1CCC2(CC(N3CCC(F)(C(=O)O)CC3)C2)C1.Cl.O=S(Cl)Cl>>CCOC(=O)N1CCC2(CC(N3CCC(F)(C(=O)NC4(C)CCC4)CC3)C2)C1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)n1sc(-c2cccc(OCc3ccccc3)c2)cc1=O.O=C(O)C(F)(F)F>>CC(C)(C)n1sc(-c2cccc(O)c2)cc1=O",
        "output": "23"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCn1cc(-n2c(C)c(Sc3cccc(CC(=O)O)c3)c3ccc(Cl)cc32)cn1.NS(=O)(=O)c1ccccc1>>CCCn1cc(-n2c(C)c(Sc3cccc(CC(=O)NS(=O)(=O)c4ccccc4)c3)c3ccc(Cl)cc32)cn1",
        "output": "801"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCC.CCOCC.CCOCC.COc1ccc(C(=O)CCCCl)cc1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.OCCO>>COc1ccc(C2(CCCCl)OCCO2)cc1",
        "output": "93"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.Cn1c(S(C)(=O)=O)nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c2c1=O.O[C@@H]1CCNC1>>Cn1c(N2CC[C@@H](O)C2)nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c2c1=O",
        "output": "679"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Br.CC(=O)O.COc1ccc2ncc(C(=O)O)c(Br)c2n1.[Na+].[OH-]>>O=C(O)c1cnc2ccc(O)nc2c1Br",
        "output": "408"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CC1OCC(CO)N(Cc2ccccc2)C1=O.CN(C)C=O.c1c[nH]cn1>>CC1OCC(CO[Si](C)(C)C(C)(C)C)N(Cc2ccccc2)C1=O",
        "output": "193"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.Cl[Pd]Cl.O=S(=O)(Nc1cc(Br)cnc1Cl)c1cccc(OC(F)F)c1.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2cnc(Cl)c(NS(=O)(=O)c3cccc(OC(F)F)c3)c2)OC1(C)C",
        "output": "943"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)C1(Cl)CC1.CCO.O.O=Cc1ccc(Cl)cc1.[Na+].[OH-]>>O=C(C=Cc1ccc(Cl)cc1)C1(Cl)CC1",
        "output": "295"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNCC1.CC(=O)O.ClCCCl.O=Cc1ccc(F)cc1>>Fc1ccc(CN2CCCCC2)cc1",
        "output": "567"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCOC(=O)c1ccc(OCCCCN2CCN(CCC(C)(C)C)CC2)c(F)c1.O.[Na+].[OH-]>>CC(C)(C)CCN1CCN(CCCCOc2ccc(C(=O)O)cc2F)CC1",
        "output": "386"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCCCn1cncn1.C1CCC2=NCCCN2CC1.CC(C)O.O=C1CCc2cc(S)ccc2N1>>O=C1CCc2cc(SCCCn3cncn3)ccc2N1",
        "output": "124"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.OCC1(O)CC2COCC(C1)N2Cc1ccccc1.[Pd]>>OCC1(O)CC2COCC(C1)N2",
        "output": "84"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.Cc1ccc(-c2nc3cccc([N+](=O)[O-])c3nc2-c2ccc(C)cc2)cc1>>Cc1ccc(-c2nc3cccc(N)c3nc2-c2ccc(C)cc2)cc1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(N)cc1-c1c(F)cnn1C.ClCCl.O=C=Nc1ccc(F)cc1>>COc1ccc(NC(=O)Nc2ccc(F)cc2)cc1-c1c(F)cnn1C",
        "output": "804"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCCCn1c(=O)c2c(NC)n[nH]c2n(CCOCc2ccccc2)c1=O.C[Si](C)(C)Cl.[I-].[Na+]>>CCCCn1c(=O)c2c(NC)n[nH]c2n(CCO)c1=O",
        "output": "178"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN1C(=O)C(C)(C)c2ccc(N)cc21.Cl.ClCCl.O.O=C(Cl)c1ccncc1.O=C([O-])[O-].[Na+].[Na+]>>CN1C(=O)C(C)(C)c2ccc(NC(=O)c3ccncc3)cc21",
        "output": "11"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)COc1ccc(C(F)(F)F)cc1-c1ccc(S(=O)(=O)C(C)C)c(F)c1.[Na+].[OH-]>>CC(C)S(=O)(=O)c1ccc(-c2cc(C(F)(F)F)ccc2OCC(=O)O)cc1F",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.OCc1cc2c(cn1)OCC2.[Mn+4].[O-2].[O-2]>>O=Cc1cc2c(cn1)OCC2",
        "output": "263"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.Nc1ccccc1.O=C=Nc1ccc(Cl)c([N+](=O)[O-])c1>>O=C(Nc1ccccc1)Nc1ccc(Cl)c([N+](=O)[O-])c1",
        "output": "473"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(NCCO[Si](C)(C)C(C)(C)C)c([N+](=O)[O-])c2)cc1.CCOC(C)=O.[Pd]>>CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(NCCO[Si](C)(C)C(C)(C)C)c(N)c2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCC(=O)N(CCN(C)C)c1ccccc1-3.ClCCl>>CN(C)CCN1C(=O)CCn2c(c(C3CCCCC3)c3ccc(C(=O)O)cc32)-c2ccccc21",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.C1COCCO1.CC1(C)OB(c2ccc(OCc3ccncc3)c(C(F)(F)F)c2)OC1(C)C.CNc1cc(Cl)nc(C#N)c1N.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>CNc1cc(-c2ccc(OCc3ccncc3)c(C(F)(F)F)c2)nc(C#N)c1N",
        "output": "955"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2CCC3(CC2)OCCO3)c2ncnn12.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(C2CCC3(CC2)OCCO3)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CC[C@@H]1CC[C@H](Oc2ccc3cc(C=O)ccc3c2)CC1.O=C1CCC(=O)N1Cl>>CC[C@H]1CC[C@@H](Oc2ccc3cc(C=O)ccc3c2Cl)CC1",
        "output": "121"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)C1CCNCC1.Cc1cc(O[C@@H]2CC[C@@H](C(C)(C)C)CC2)c(C=O)c2ccccc12.[BH3-]C#N.[Na+]>>CCOC(=O)C1CCN(Cc2c(O[C@@H]3CC[C@@H](C(C)(C)C)CC3)cc(C)c3ccccc23)CC1",
        "output": "567"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.O=[Pt]=O.[N-]=[N+]=NCc1cn(-c2ccccc2Cl)c2cc(Cl)ccc2c1=O>>NCc1cn(-c2ccccc2Cl)c2cc(Cl)ccc2c1=O",
        "output": "89"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)(C)[Si](C)(C)OCCn1c(CCl)nc2cnc3cc(OCc4ccccc4)ccc3c21.O>>OCCn1c(CCl)nc2cnc3cc(OCc4ccccc4)ccc3c21",
        "output": "708"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1ccc(C(=O)NN=C(C)c2nn(C)c(-c3ccc(CC(C)C)cc3)c2O)cc1.Cl.O.[Na+].[OH-]>>CC(=NNC(=O)c1ccc(C(=O)O)cc1)c1nn(C)c(-c2ccc(CC(C)C)cc2)c1O",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.Cl[Pd]Cl.O.O=C(NCc1cc(Br)ccc1F)[C@@H]1C[C@@H](F)CN1S(=O)(=O)c1ccc(F)cc1.O=C([O-])[O-].OB(O)c1ccc(C(F)(F)F)cc1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=C(NCc1cc(-c2ccc(C(F)(F)F)cc2)ccc1F)[C@@H]1C[C@@H](F)CN1S(=O)(=O)c1ccc(F)cc1",
        "output": "908"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCc1nc2c(Cl)nc(C)cc2n1-c1ccc(CCNC(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCc1nc2c(Cl)nc(C)cc2n1-c1ccc(CCN)cc1",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.COC(=O)Cc1cccc(O)c1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCOc1cccc(CC(=O)O)c1",
        "output": "928"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=O.CC#N.CC(=O)O.CC(C)=O.CNC1(c2ccc(N3CCc4c(C(F)(F)F)nn(-c5ccc(OC)cc5)c4C3=O)cc2)CC1.[BH3-]C#N.[Na+].[Na+].[OH-]>>COc1ccc(-n2nc(C(F)(F)F)c3c2C(=O)N(c2ccc(C4(N(C)C)CC4)cc2)CC3)cc1",
        "output": "69"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1cnc(Cl)c(Cl)c1.CCOC(C)=O.CN(C)C=O.N[C@@H]1CCN(Cc2ccccc2)C1.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cnc(N[C@@H]2CCN(Cc3ccccc3)C2)c(Cl)c1",
        "output": "70"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C#N)(CC1CC1)c1cccc(C(=O)O)c1.CN(C)C=O.CN1CCCC1=O.COc1ccc(N)cc1Oc1ccc2nc(NC(=O)C3CC3)cn2n1.O=C(Cl)C(=O)Cl>>COc1ccc(NC(=O)c2cccc(C(C)(C#N)CC3CC3)c2)cc1Oc1ccc2nc(NC(=O)C3CC3)cn2n1",
        "output": "817"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1c(Cl)cc(C(C)(C)C)c(O)c1C(=O)O.N#Cc1cc(S(=O)(=O)C(F)(F)F)ccc1N>>Cc1c(Cl)cc(C(C)(C)C)c(O)c1C(=O)Nc1ccc(S(=O)(=O)C(F)(F)F)cc1C#N",
        "output": "50"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CCO.Cl.Nc1c(NCCCOc2cccc(C=O)c2)c(=O)c1=O.O.[Pd]>>Nc1c(NCCCOc2cccc(CO)c2)c(=O)c1=O",
        "output": "356"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N1CCC(CC(=O)Nc2ccc(Br)cc2)CC1.OB(O)c1cccc(F)c1F>>CC(=O)N1CCC(CC(=O)Nc2ccc(-c3cccc(F)c3F)cc2)CC1",
        "output": "837"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CC1CC(O)CCO1.CCCCc1nc(C)n(-c2ccc(O)cc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCCc1nc(C)n(-c2ccc(OC3CCOC(C)C3)cc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "846"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cl.NCc1ccc(F)cc1.O=C(O)c1cc2cc(OCCCN3CCCCC3)cnc2[nH]1>>O=C(NCc1ccc(F)cc1)c1cc2cc(OCCCN3CCCCC3)cnc2[nH]1",
        "output": "905"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCCOc1c(/C(C)=C(/F)CO)cc2c(c1Br)C(C)(C)CC=C2C(C)C.CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-]>>CCCOc1c(/C(C)=C(/F)C=O)cc2c(c1Br)C(C)(C)CC=C2C(C)C",
        "output": "183"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)CBr.CN(C)C=O.O=C([O-])[O-].O=S(=O)(c1ccccc1)c1ccc(-c2cc(Cl)ccc2O)cc1.[K+].[K+]>>CC(C)(C)OC(=O)COc1ccc(Cl)cc1-c1ccc(S(=O)(=O)c2ccccc2)cc1",
        "output": "393"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1CCCCN1.Cc1cc(C#N)cnc1F>>Cc1cc(C#N)cnc1N1CCCCC1C",
        "output": "756"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1=CCCCC1.CC1CN(c2ccc([N+](=O)[O-])c(C(=O)O)c2)CC(C)O1.[Pd]>>CC1CN(c2ccc(N)c(C(=O)O)c2)CC(C)O1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1noc(-c2ccc(Br)cc2)c1C(CCCc1ccccc1)NS(C)(=O)=O>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4C(CCCc4ccccc4)NS(C)(=O)=O)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)c1ccccc1.CC(C)(C)O[Na].CC(C)O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(O)c1ccccc1",
        "output": "24"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)c1ccc(C(=O)O)cc1C#N.CCOC(=O)CCl>>CC(C)c1ccc(CO)cc1C#N",
        "output": "72"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(N)CO.CCCCc1noc(C)c1COc1ccc(C(=O)OC)cn1>>CCCCc1noc(C)c1COc1ccc(C(=O)NC(C)(C)CO)cn1",
        "output": "862"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.CCN(CC)CC.CON=C1C[C@@H](c2nc(C3CCNCC3)no2)N(C(=O)c2ccc(-c3ccccc3)cc2)C1.ClCCl.O=C([O-])[O-].[Na+].[Na+]>>CON=C1C[C@@H](c2nc(C3CCN(C(C)=O)CC3)no2)N(C(=O)c2ccc(-c3ccccc3)cc2)C1",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)NCCCl.CN(C)C=O.O=C([O-])[O-].Oc1cc(Oc2ccccc2)ccc1Cl.[K+].[K+]>>CCOC(=O)NCCOc1cc(Oc2ccccc2)ccc1Cl",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)C(NC(=O)Cn1c(-c2ccccc2)ncc(NC(=O)NCc2cccnc2)c1=O)C(O[Si](C)(C)C(C)(C)C)C(F)(F)F.CO.ClCCl>>CC(C)C(NC(=O)Cn1c(-c2ccccc2)ncc(NC(=O)NCc2cccnc2)c1=O)C(O)C(F)(F)F",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CCO.O=C1Cc2ccccc2N1.O=Cc1[nH]c2c(c1CCCN1CCOCC1)CCCCC2>>O=C1Nc2ccccc2/C1=C/c1[nH]c2c(c1CCCN1CCOCC1)CCCCC2",
        "output": "911"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@@H]1CN(c2ccc(F)cc2C(F)(F)F)CCN1S(=O)(=O)c1ccc(C2CCN(C(=O)OC(C)(C)C)CC2)s1.ClCCl.O=C(O)C(F)(F)F>>C[C@@H]1CN(c2ccc(F)cc2C(F)(F)F)CCN1S(=O)(=O)c1ccc(C2CCNCC2)s1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.Nc1cc(B(O)O)c(F)cc1F.O=C=Nc1ccc(C(F)(F)F)cc1>>O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cc(B(O)O)c(F)cc1F",
        "output": "473"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1cc(-c2cnn(CCN3CCOCC3)c2)ccc1OCc1ccc(F)cc1.O.[Li+].[OH-]>>O=C(O)c1cc(-c2cnn(CCN3CCOCC3)c2)ccc1OCc1ccc(F)cc1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CO.COC(=O)C(c1ccccc1)N1CCCc2cc(OC)c(OC)cc2C1Cc1ccc(OC)c(OC)c1.[Na+].[OH-]>>COc1ccc(CC2c3cc(OC)c(OC)cc3CCCN2C(C(=O)O)c2ccccc2)cc1OC",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O=C(c1ccc(Cc2ccc([N+](=O)[O-])cc2)cc1)N1CCCC1.[Pd]>>Nc1ccc(Cc2ccc(C(=O)N3CCCC3)cc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Fc1cnc(Cl)nc1Cl.Fc1cnc(Cl)nc1Nc1cccc(-c2nnn[nH]2)c1.Nc1ccc(Cl)c(C(F)(F)F)c1>>Fc1cnc(Cl)nc1Nc1ccc(Cl)c(C(F)(F)F)c1",
        "output": "161"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.Cc1onc(-c2ccc(F)cc2)c1CO.Clc1ccc(Br)cn1.O.[H-].[Na+]>>Cc1onc(-c2ccc(F)cc2)c1COc1ccc(Br)cn1",
        "output": "433"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCOC(=O)c1csc(SCC[C@@H]2[C@@H](CO)CC[C@@H]2OC(C)=O)n1.CCOC(C)=O.CS(C)=O.Cl.[S]>>CCOC(=O)c1csc(SCC[C@@H]2[C@@H](C=O)CC[C@@H]2OC(C)=O)n1",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "B.C1CCOC1.C1COCCO1.CC(C)CC1C(=O)NCCN1Cc1ccccc1-c1ccc(Cl)cc1.CO.CSC.Cl>>CC(C)CC1CNCCN1Cc1ccccc1-c1ccc(Cl)cc1",
        "output": "490"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CN(CCCCC(=O)OC[C@@H]1CC(c2ccc(-c3ccc(N4C[C@H](Cn5ccnn5)OC4=O)cc3F)cn2)=NO1)C(=O)OC(C)(C)C.CO.Cl>>CNCCCCC(=O)OC[C@@H]1CC(c2ccc(-c3ccc(N4C[C@H](Cn5ccnn5)OC4=O)cc3F)cn2)=NO1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.N#CC1(c2ccccc2)CCC(=O)CC1.[BH4-].[Na+]>>N#CC1(c2ccccc2)CCC(O)CC1",
        "output": "91"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Cc1cc2nc(NC(=O)OC(C)(C)C)[nH]c2c(C)c1[N+](=O)[O-].[H][H]>>Cc1cc2nc(NC(=O)OC(C)(C)C)[nH]c2c(C)c1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrC(Br)(Br)Br.C=CCCCCCCCCCCCO.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C=CCCCCCCCCCCCBr",
        "output": "378"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cc(Nc2cncc(Cl)n2)cc(OC)c1OC.O=C([O-])[O-].Oc1ccccc1.[K+].[K+]>>COc1cc(Nc2cncc(Oc3ccccc3)n2)cc(OC)c1OC",
        "output": "210"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1cc(N2CCCCCC2)c2ccc(CO)cc2n1.N#Cc1ccc(F)cc1.[H-].[Na+]>>Cc1cc(N2CCCCCC2)c2ccc(COc3ccc(C#N)cc3)cc2n1",
        "output": "485"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)CC1.CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.CC(C)n1c(C(=O)N2CCS(=O)(=O)CC2)cc2cc(O)ccc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)n1c(C(=O)N2CCS(=O)(=O)CC2)cc2cc(OC3CCN(C(=O)OC(C)(C)C)CC3)ccc21",
        "output": "846"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)O.CCN=C=NCCCN(C)C.CCOC(C)=O.CN1CCOCC1.C[C@H]1CN(Cc2ccc(-c3ccc(C(CC4CCOCC4)c4ccc(S(=O)(=O)C5CC5)cc4)[nH]3)nc2)CCN1.Cl.On1nnc2ccccc21>>CC(=O)N1CCN(Cc2ccc(-c3ccc(C(CC4CCOCC4)c4ccc(S(=O)(=O)C5CC5)cc4)[nH]3)nc2)C[C@@H]1C",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.O=C(N[C@@H](Cc1ccccc1)C(=O)O)OCc1ccccc1.O=[N+]([O-])c1ccc(O)cc1.[C-]#[N+]C(C)C>>O=C(N[C@@H](Cc1ccccc1)C(=O)Oc1ccc([N+](=O)[O-])cc1)OCc1ccccc1",
        "output": "108"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)c1c(CF)nn(C)c1CF.[Na+].[OH-]>>Cn1nc(CF)c(C(=O)O)c1CF",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)NCCn1cc(C(=O)N2CCN(c3ccccc3F)CC2)c2ccc(Cl)cc21.CI.CN(C)C=O.[H-].[Na+]>>CC(=O)N(C)CCn1cc(C(=O)N2CCN(c3ccccc3F)CC2)c2ccc(Cl)cc21",
        "output": "83"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(O)CCc1ccc(F)cc1.O=S(Cl)Cl>>O=C(Cl)CCc1ccc(F)cc1",
        "output": "53"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)c1ccc(B(O)O)cc1.CN(C)C=O.ClCCl.Cl[Pd]Cl.O=C(OCc1ccccc1)c1cc(Cl)nc2ccccc12.O=P([O-])([O-])[O-].[Fe+2].[K+].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(=O)c1ccc(-c2cc(C(=O)OCc3ccccc3)c3ccccc3n2)cc1",
        "output": "865"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.O=[Cr](=O)([O-])Cl.OCc1ccc(OC2C=CCCC2)cc1.c1cc[nH+]cc1>>O=Cc1ccc(OC2C=CCCC2)cc1",
        "output": "179"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.Cl.Fc1ccc(C(F)(F)CCBr)cc1.O.O=C(O)c1ccccc1S.O=C([O-])[O-].[K+].[K+]>>O=C(O)c1ccccc1SCCC(F)(F)c1ccc(F)cc1",
        "output": "124"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNCC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(C=O)CC1.ClCCCl.[Na+]>>CC(C)(C)OC(=O)N1CCC(CN2CCCCC2)CC1",
        "output": "484"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-n3ncc4cc(Cl)ccc43)nc12.ClCCl.O=C(O)C(F)(F)F>>CC(C)(C)NC(=O)c1c[nH]c2ncc(-n3ncc4cc(Cl)ccc43)nc12",
        "output": "981"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[N-]=[N+]=NCC(O)COCCCCCCCCc1ccccc1>>NCC(O)COCCCCCCCCc1ccccc1",
        "output": "89"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCc1[nH]c(C(=O)O)nc1Cl.CN(C)[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1N.Cl.O.On1nnc2ccccc21>>CCc1[nH]c(C(=O)N[C@H]2CCN(C(=O)OC(C)(C)C)C[C@H]2N(C)C)nc1Cl",
        "output": "951"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2ccc(-c3cn(S(=O)(=O)c4ccccc4)c4cc(F)ccc34)cn2)CC1.CCOCC.CO.Cl>>O=S(=O)(c1ccccc1)n1cc(-c2ccc(OC3CCNCC3)nc2)c2ccc(F)cc21",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CC(C)(C)O[K].COc1cc2nc(Cl)nc(N3CCCCC3)c2cc1OC.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COc1cc2nc(NC3CCN(C(=O)OC(C)(C)C)CC3)nc(N3CCCCC3)c2cc1OC",
        "output": "544"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.C[Si](C)(C)[N-][Si](C)(C)C.Cc1cccc(C)c1Br.Cl.O.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C([O-])O.OCC1CCNC1.[Li+].[Na+].[Pd]>>Cc1cccc(C)c1N1CCC(CO)C1",
        "output": "294"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNC1.COC(=O)c1ccc(F)cc1OCCCNC(=O)OC(C)(C)C>>COC(=O)c1ccc(N2CCCC2)cc1OCCCNC(=O)OC(C)(C)C",
        "output": "773"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cccc(N)c1.Fc1ccc(Nc2cc(Cl)ncn2)cc1Cl>>COc1cccc(Nc2cc(Nc3ccc(F)c(Cl)c3)ncn2)c1",
        "output": "161"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=C1CCc2cc(Br)ccc21.O=[N+]([O-])O>>O=C1CCc2cc(Br)c([N+](=O)[O-])cc21",
        "output": "21"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1cc([N+](=O)[O-])cc2cc[nH]c12.[Pd]>>Cc1cc(N)cc2cc[nH]c12",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CO.CO.COc1cnc2ccc(=O)n(CCN3CCC(N)CC3)c2c1.C[O-].Cl.ClC(Cl)Cl.O.O=C([O-])O.O=Cc1cnc2cccnc2c1.[BH3-]C#N.[Na+].[Na+].[Na+]>>COc1cnc2ccc(=O)n(CCN3CCC(NCc4cnc5cccnc5c4)CC3)c2c1",
        "output": "441"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(CCc4ccccc4)c3)c3cc(-c4ccc(F)c(NS(C)(=O)=O)c4)cnc32)cc1.O.[Li+].[OH-]>>CS(=O)(=O)Nc1cc(-c2cnc3[nH]cc(-c4cnn(CCc5ccccc5)c4)c3c2)ccc1F",
        "output": "949"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)cc1C.Cl.O.[Na+].[OH-]>>Cc1cc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CCO.CCOc1cc(C=O)ccc1OC.COC(=O)COc1cccc2nc(NC3CCNCC3)oc12.[BH3-]C#N.[Na+]>>CCOc1cc(CN2CCC(Nc3nc4cccc(OCC(=O)OC)c4o3)CC2)ccc1OC",
        "output": "567"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.ClCCCI.O=[N+]([O-])c1ccc2cc[nH]c2c1.[H-].[Na+]>>O=[N+]([O-])c1ccc2ccn(CCCCl)c2c1",
        "output": "302"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)C[C@H]1CC[C@@H](OC2CCNCC2)CC1.O.[Li+].[OH-]>>O=C(O)C[C@H]1CC[C@@H](OC2CCNCC2)CC1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COP(=O)(O)C1N2C(=O)C(N)[C@H]2SC1(C)C.O.O=C(Cl)Cc1ccccc1.[Na+].[OH-]>>COP(=O)(O)C1N2C(=O)C(NC(=O)Cc3ccccc3)[C@H]2SC1(C)C",
        "output": "159"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CN1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1.COc1ccc(Cl)c(-c2cc(C)c3nc(N)nnc3c2)c1.[K+].[Pd+2]>>COc1ccc(Cl)c(-c2cc(C)c3nc(Nc4ccc(S(=O)(=O)N5CCN(C)CC5)cc4)nnc3c2)c1",
        "output": "970"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(CCBr)cc1.[K+].[K+].c1ccc(CNCCCN2CCOCC2)cc1>>O=[N+]([O-])c1ccc(CCN(CCCN2CCOCC2)Cc2ccccc2)cc1",
        "output": "722"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.O=C(Cl)OCc1ccccc1.O=C([O-])O.O[C@H]1CCNC1.[Na+]>>O=C(OCc1ccccc1)N1CC[C@H](O)C1",
        "output": "427"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCN(CC(=O)O)c1ccc(C=O)cc1[N+](=O)[O-].CCO.O.[BH4-].[Na+]>>CCN(CC(=O)O)c1ccc(CO)cc1[N+](=O)[O-]",
        "output": "356"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(CCO)n1cc(-c2ncnc3c2ccn3COCC[Si](C)(C)C)cn1.COC(=O)Cl.O.c1ccncc1>>CCC(CCOC(=O)OC)n1cc(-c2ncnc3c2ccn3COCC[Si](C)(C)C)cn1",
        "output": "144"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1nc2c3c(c(C(=O)O)cc2n1C)CCC1(Cc2ccccc2C1)N3.F[B-](F)(F)F.N>>Cc1nc2c3c(c(C(N)=O)cc2n1C)CCC1(Cc2ccccc2C1)N3",
        "output": "358"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccccc1.ClC(Cl)Cl.Fc1ncccc1-c1cc(Cl)nc2c1CCCC2.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].OCc1cccc(F)n1.[Cs+].[Cs+].[Pd].[Pd]>>Fc1cccc(COc2cc(-c3cccnc3F)c3c(n2)CCCC3)n1",
        "output": "433"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.Cl.O.OCc1c[nH]cn1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCc1c[nH]cn1",
        "output": "193"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(=CCO[C@@H]1CCC[C@H](OCc2nc(-c3ccc(F)cc3)oc2C)C1)CC.CCOC(C)=O.CO.Cl.[Na+].[OH-]>>CCC(=CCO[C@@H]1CCC[C@H](OCc2nc(-c3ccc(F)cc3)oc2C)C1)C(=O)O",
        "output": "122"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1nc(C2CCC2)cc(N2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2)n1.CCO.NN.O>>CC(C)(C)c1nc(C2CCC2)cc(N2CCN(CCCCN)CC2)n1",
        "output": "242"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)CCCl.CS(C)=O.Cl.O=[N+]([O-])c1cccc(O)c1.[K+].[OH-]>>CN(C)CCOc1cccc([N+](=O)[O-])c1",
        "output": "74"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1ccccc1.CCOC(=O)COc1ccc(Sc2cc(Br)cc(OCC(CC)CC)c2)cc1C.CCOC(=O)COc1ccc(Sc2cc(C#Cc3ccc(CO)cc3)cc(OCCc3ccc(Cl)cc3)c2)cc1C>>CCOC(=O)COc1ccc(Sc2cc(C#Cc3ccccc3)cc(OCC(CC)CC)c2)cc1C",
        "output": "659"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#CCBr.CO.Cc1ccccc1.O=Cc1ccc(Br)cc1O.[Na+].[OH-]>>C#CCOc1cc(Br)ccc1C=O",
        "output": "154"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C[O-].O=[N+]([O-])c1cc(C(F)(F)F)ccc1Cl.[Na+]>>COc1ccc(C(F)(F)F)cc1[N+](=O)[O-]",
        "output": "57"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCNC(C(F)(F)F)C1.CO.COc1cc(CC=O)ccc1C#N.[BH3-]C#N.[Na+]>>COc1cc(CCN2CCN(C(=O)OC(C)(C)C)CC2C(F)(F)F)ccc1C#N",
        "output": "484"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.Cc1[nH]nc(Nc2ccnc3ccc(SC4CCOC4)cc23)c1C.O.O=S([O-])OO.[K+]>>Cc1[nH]nc(Nc2ccnc3ccc(S(=O)(=O)C4CCOC4)cc23)c1C",
        "output": "730"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(C(=O)O)c(F)c1.O=S(=O)(O)O.O=[N+]([O-])O>>Cc1cc(F)c(C(=O)O)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2ccc3c(c2)cc2n3CCNC2=O)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C1NCCn2c1cc1cc(OC3CCNCC3)ccc12",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)Cc1c(C)n(Cc2ccc([N+](=O)[O-])cc2)c2ncccc12.[Na+].[OH-]>>Cc1c(CC(=O)O)c2cccnc2n1Cc1ccc([N+](=O)[O-])cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NCCN(CC1CCCCC1)S(=O)(=O)c1ccccn1.CC(C)O.Cl>>NCCN(CC1CCCCC1)S(=O)(=O)c1ccccn1",
        "output": "538"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CNC.ClCCl.O=[N+]([O-])c1ccc(Cc2ccc(S(=O)(=O)Cl)cc2)cc1>>CN(C)S(=O)(=O)c1ccc(Cc2ccc([N+](=O)[O-])cc2)cc1",
        "output": "99"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.Cc1cnc(Cl)nc1N.Nc1cccc(S(=O)(=O)N2CCCCC2)c1>>Cc1cnc(Nc2cccc(S(=O)(=O)N3CCCCC3)c2)nc1N",
        "output": "808"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCOc1c(OC)cc(C(=O)Cl)cc1OC.CCN(C)C1(CN)CCCCC1>>CCCCOc1c(OC)cc(C(=O)NCC2(N(C)CC)CCCCC2)cc1OC",
        "output": "271"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2C2CCCN2C(C)=O)cn1.ClC(Cl)Cl.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(=O)N1CCCC1c1cc2[nH]c(-c3ccccn3)nc2cc1Oc1ccc(CO)nc1",
        "output": "711"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.Oc1ccccc1>>CS(=O)(=O)Oc1ccccc1",
        "output": "149"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCI.CN(C)C=O.O=C([O-])[O-].O=Cc1cc(Br)c(-c2ccc(F)cc2)c(F)c1O.[K+].[K+]>>CCOc1c(C=O)cc(Br)c(-c2ccc(F)cc2)c1F",
        "output": "198"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOc1ccc(C(CO)C(F)(F)F)cc1.CN(C)C=O.Fc1ccc(Oc2cccc(CBr)c2)cc1.[H-].[Na+]>>CCOc1ccc(C(COCc2cccc(Oc3ccc(F)cc3)c2)C(F)(F)F)cc1",
        "output": "464"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)c1ccc(CNC(=O)OCc2ccccc2)cc1OCc1ccccc1.Cl.O.O.[Li+].[OH-]>>O=C(NCc1ccc(C(=O)O)c(OCc2ccccc2)c1)OCc1ccccc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C(=O)O)c1ccc2cc(O)ccc2c1.CCCCI>>CCCCOc1ccc2cc(C(C)C(=O)O)ccc2c1",
        "output": "198"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(CC)CC.NC(CO)CO.O=S(=O)(Cl)c1ccc(Cl)s1>>O=S(=O)(NC(CO)CO)c1ccc(Cl)s1",
        "output": "600"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)CN([C@@H](CCCCN)C(=O)O)S(=O)(=O)c1ccc([N+](=O)[O-])cc1.O=C(O)C=Cc1cccc([N+](=O)[O-])c1>>CC(C)CN([C@@H](CCCCNC(=O)C=Cc1cccc([N+](=O)[O-])c1)C(=O)O)S(=O)(=O)c1ccc([N+](=O)[O-])cc1",
        "output": "549"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClC(Cl)Cl.Nc1cccc(OCCCN2CCOCC2)c1.O.O=C(O)Cc1ccc2c(c1)OCO2.On1nnc2ccccc21>>O=C(Cc1ccc2c(c1)OCO2)Nc1cccc(OCCCN2CCOCC2)c1",
        "output": "365"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cc(-c2cccc(OC)c2)n(-c2ccc(F)c(Cl)c2)n1.O=C(O)c1cc(-c2cc(F)cc(Cl)c2)n(-c2ccc(F)c(Cl)c2)n1>>COc1cccc(-c2cc(C(=O)O)nn2-c2ccc(F)c(Cl)c2)c1",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCn1c2c(c3cc(C)ccc31)CN(C)CC2.NC1CCCC1>>Cc1ccc2c(c1)c1c(n2CCC(=O)NC2CCCC2)CCN(C)C1",
        "output": "64"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.CCN(CC)CC.CN(C)C(=O)c1cc(Cl)nc2ccccc12.Cl.ClC(Cl)Cl.N[C@H]1CCN(C(=O)Cc2ccc(OC(F)(F)F)cc2)C1>>CN(C)C(=O)c1cc(N[C@H]2CCN(C(=O)Cc3ccc(OC(F)(F)F)cc3)C2)nc2ccccc12",
        "output": "70"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.CCOC(C)=O.COc1cc(C)cc(C)c1-c1cccc2c(N(CC3CC3)CC3CC3)c(SC)nn12.ClCCl.ClCCl>>CSc1nn2c(-c3c(C)cc(C)cc3O)cccc2c1N(CC1CC1)CC1CC1",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CN(C)CCCl.O=C([O-])[O-].Oc1ccc2c(Cl)nccc2c1.[Cs+].[Cs+]>>CN(C)CCOc1ccc2c(Cl)nccc2c1",
        "output": "74"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(c1ccc(Cl)cc1)(n1ccc2c(NC(=O)OC(C)(C)C)cccc21)C1(O)CC1.CO.Cl>>CCC(c1ccc(Cl)cc1)(n1ccc2c(N)cccc21)C1(O)CC1",
        "output": "782"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N(c1cc(CCC=O)ccc1-c1ccccc1)[C@@H]1CC[C@@H](N)CC1.CCN(C(C)C)C(C)C.CN.CO.ClC(Cl)Cl.[BH3-]C#N.[Na+]>>CNCCCc1ccc(-c2ccccc2)c(N(C(=O)OC(C)(C)C)[C@@H]2CC[C@@H](N)CC2)c1",
        "output": "426"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)cc1Cl.Oc1ccccc1-c1ccccc1.[K+].[K+]>>O=[N+]([O-])c1ccc(Cl)cc1Oc1ccccc1-c1ccccc1",
        "output": "299"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.CO.FC(F)(F)c1cc(Cl)nc(Cl)c1.[Na+].[OH-]>>COc1cc(C(F)(F)F)cc(Cl)n1",
        "output": "433"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O=C(O)c1ccc2c(c1)C=C(n1ccnc1)CC2.O=S(Cl)Cl>>CCOC(=O)c1ccc2c(c1)C=C(n1ccnc1)CC2",
        "output": "33"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.COc1cccc2oc(S(=O)(=O)N(C)C)cc12>>CN(C)S(=O)(=O)c1cc2c(O)cccc2o1",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1c(O)c2ncc(Cc3ccccc3)cc2n(Cc2ccc([N+](=O)[O-])cc2)c1=O.NCc1ccco1>>O=C(NCc1ccco1)c1c(O)c2ncc(Cc3ccccc3)cc2n(Cc2ccc([N+](=O)[O-])cc2)c1=O",
        "output": "498"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1ccc(F)cc1Cl.Oc1ccccc1Cl>>CC(=O)c1ccc(Oc2ccccc2Cl)cc1Cl",
        "output": "564"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Nc1nc2cnc(N(C)c3ccc(F)c(NC(=O)OC(C)(C)C)c3)nc2s1.COc1ccccc1.O=C(O)C(F)(F)F>>CC(=O)Nc1nc2cnc(N(C)c3ccc(F)c(N)c3)nc2s1",
        "output": "782"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)C1CC(Oc2nc3c(F)c(-c4ccc(-c5ccccc5)cc4)c(F)cc3[nH]2)C1.CCOC(C)=O.C[Si](C)(C)O[K]>>O=C(O)C1CC(Oc2nc3c(F)c(-c4ccc(-c5ccccc5)cc4)c(F)cc3[nH]2)C1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cccnc1N.Cl.[Na+].[OH-]>>Nc1ncccc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCc2ccc(-c3noc(-c4ccc(F)c(C#N)c4)n3)cc2CC1.CC(C)N.CN(C)C=O.[H-].[Na+]>>CC(C)Nc1ccc(-c2nc(-c3ccc4c(c3)CCN(C(=O)OC(C)(C)C)CC4)no2)cc1C#N",
        "output": "572"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.Cl.O=C(NC1CC2CCCC(C1)N2)C1c2ccccc2Oc2ccccc21.O=C([O-])O.O=CC1CCCCCCC1.[Na+].[Na+]>>O=C(NC1CC2CCCC(C1)N2CC1CCCCCCC1)C1c2ccccc2Oc2ccccc21",
        "output": "484"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(N)(CC(N)=O)C1CC1.O=C(O)c1cc(OCC(F)(F)F)c(C2(F)CCC2)cn1>>CC(CC(N)=O)(NC(=O)c1cc(OCC(F)(F)F)c(C2(F)CCC2)cn1)C1CC1",
        "output": "137"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1CCc1cccc(N2C(=O)N(c3ccccc3Br)Cc3cnc(Nc4ccccc4)nc32)c1>>NCCc1cccc(N2C(=O)N(c3ccccc3Br)Cc3cnc(Nc4ccccc4)nc32)c1",
        "output": "242"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COCCOC.Cc1cc(C)c(CNC(=O)c2cc(Cl)nc3c2cnn3C(C)C)c(=O)[nH]1.ClCCl.ClCCl.Cl[Pd]Cl.Nc1ccc(B(O)O)cc1.O.O=C([O-])O.[Fe+2].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(N)cc3)nc3c2cnn3C(C)C)c(=O)[nH]1",
        "output": "865"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)C=O.CO.NCCn1c(Sc2cc3c(cc2Cl)OCO3)nc2c(N)nccc21.O.[BH3-]C#N.[Na+]>>CC(C)(C)CNCCn1c(Sc2cc3c(cc2Cl)OCO3)nc2c(N)nccc21",
        "output": "426"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.NC(=O)c1ccccc1Nc1cccc([N+](=O)[O-])c1>>N#Cc1ccccc1Nc1cccc([N+](=O)[O-])c1",
        "output": "374"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cc1ccc(CC#N)c(OCc2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)n1.Cl.O.[Na+].[OH-]>>Cc1ccc(CC(=O)O)c(OCc2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)n1",
        "output": "259"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOc1ccc2ccccc2c1C(=O)O.c1ccc2nc(N3CC4CNCC4C3)cnc2c1>>CCOc1ccc2ccccc2c1C(=O)N1CC2CN(c3cnc4ccccc4n3)CC2C1",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)[C@@H]1CCS(=O)(=O)N1Cc1cccc(COc2ccc(-c3cc(F)c(F)cc3F)cc2)c1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)[C@@H]1CCS(=O)(=O)N1Cc1cccc(COc2ccc(-c3cc(F)c(F)cc3F)cc2)c1",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCOC(CO)C(c2ccc(Cl)c(Cl)c2)C1.CI.[H-].[Na+]>>COCC1OCCN(C(=O)OC(C)(C)C)CC1c1ccc(Cl)c(Cl)c1",
        "output": "140"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(CC)CC.O=[N+]([O-])c1ccc(Cl)c(S(=O)(=O)Cl)c1Cl>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2c(Cl)ccc([N+](=O)[O-])c2Cl)CC1",
        "output": "99"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCC=O.ClCCl.O=C(NCCNC(=O)C1CCCNC1)c1cn(-c2ccccc2)nc1C(F)(F)F.[Na+].[Na+].[OH-]>>CCCN1CCCC(C(=O)NCCNC(=O)c2cn(-c3ccccc3)nc2C(F)(F)F)C1",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.O=C(Cl)C=Cc1ccccc1.OCCCCCCBr>>O=C(C=Cc1ccccc1)OCCCCCCBr",
        "output": "320"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.COC(=O)CC1Nc2ccccc2N(C)n2cccc21.O=C(Cl)c1ccccc1>>COC(=O)CC1c2cccn2N(C)c2ccccc2N1C(=O)c1ccccc1",
        "output": "614"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[O-].CCC(N)CO.Cc1ccccc1.FC(F)(F)Oc1cccc(-c2cnc3ccc(Cl)nn23)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CCC(CO)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1",
        "output": "241"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)c1c(Cl)nc(-c2cccnc2)n1Cc1cc(Cl)ccc1Cl.CO.Cl.[Na+].[OH-]>>O=C(O)c1c(Cl)nc(-c2cccnc2)n1Cc1cc(Cl)ccc1Cl",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1ccccc1[N+](=O)[O-].CCOCC>>CC(O)c1ccccc1[N+](=O)[O-]",
        "output": "24"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)C(c1ccc([N+](=O)[O-])cc1)n1ccnc1.CO.[Ni]>>CC(C)C(c1ccc(N)cc1)n1ccnc1",
        "output": "507"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCCCN.O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](c2ccccc2)[C@H](c2cccc(Cl)c2)C1.c1ccc(-c2ccccc2P(C2CCCCC2)C2CCCCC2)cc1>>COCCCNc1cccc([C@@H]2CN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC[C@@H]2c2ccccc2)c1",
        "output": "304"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCCC/C=C/C(=O)O.O=C1CCNCC1>>CCCCCCC/C=C/C(=O)N1CCC(=O)CC1",
        "output": "870"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1cc2cc(F)c(C(F)(F)F)cc2[nH]1.[Na+].[OH-]>>O=C(O)c1cc2cc(F)c(C(F)(F)F)cc2[nH]1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(OC(F)(F)F)cc1C(=O)O.COc1ccc2nc(-c3ccc(N)cc3OC)sc2c1.O=S(Cl)Cl.c1ccncc1>>COc1ccc2nc(-c3ccc(NC(=O)c4cc(OC(F)(F)F)ccc4OC)cc3OC)sc2c1",
        "output": "50"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCN(CC)CC.C[Si](C)(C)C#N.[O-][n+]1ccc(-c2cc(F)ccc2C(F)(F)F)cc1>>N#Cc1cc(-c2cc(F)ccc2C(F)(F)F)ccn1",
        "output": "720"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)NCc1ccc(-c2nccnc2N2CCN(C(=O)OC(C)(C)C)CC2)cc1.ClCCl.O=C(O)C(F)(F)F>>CC(=O)NCc1ccc(-c2nccnc2N2CCNCC2)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CNC(=O)CC(SC(=O)c1ccccc1)C(CC(C)C)C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>CNC(=O)CC(SC(=O)c1ccccc1)C(CC(C)C)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Clc1nccnc1OCC1CO1.NCCOc1ccccc1C(N)=O>>NC(=O)c1ccccc1OCCNCC(O)COc1nccnc1Cl",
        "output": "16"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.CNCC1CCN(Cc2ccccc2)CC1.O=C(CCCI)c1ccc(F)cc1.O=C([O-])[O-].[K+].[K+]>>CN(CCCC(=O)c1ccc(F)cc1)CC1CCN(Cc2ccccc2)CC1",
        "output": "184"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)CCC(c1nc2cc(C#N)ccc2[nH]1)c1c(OC)cc(C)c2[nH]ccc12>>COc1cc(C)c2[nH]ccc2c1C(CCC(=O)O)c1nc2cc(C#N)ccc2[nH]1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Brc1c[nH]cn1.Cc1cc(-c2ccc(Cl)c(Cl)c2)nc(Cl)n1>>Cc1cc(-c2ccc(Cl)c(Cl)c2)nc(-n2cnc(Br)c2)n1",
        "output": "788"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1nc2ccc(C=O)cc2o1.O=C1CSC(=S)N1.c1ccncc1>>Cc1nc2ccc(C=C3SC(=S)NC3=O)cc2o1",
        "output": "314"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.NN.O.OCc1ccnc(Cl)c1>>NNc1cc(CO)ccn1",
        "output": "417"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cl.O=C(O)c1cn(C2CC2)c2c(F)c(F)c(F)cc2c1=O.[N-]=[N+]=C1CCCCCCCCCC1C1CCCCCCCCCC1.c1ccc(-c2cn(C3CCNC3)nn2)cc1.c1ccncc1>>O=C(O)c1cn(C2CC2)c2c(F)c(N3CCC(n4cc(-c5ccccc5)nn4)C3)c(F)cc2c1=O",
        "output": "676"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)C1CCNC(=O)OCc1ccccc1.CCN(C(C)C)C(C)C.CCOC(C)=O.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)N1CCC(OS(C)(=O)=O)C1CCNC(=O)OCc1ccccc1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "O=C(Cl)N1CCOCC1.Oc1ccc(Oc2ncc(Cl)cc2Cl)cc1>>O=C(Oc1ccc(Oc2ncc(Cl)cc2Cl)cc1)N1CCOCC1",
        "output": "425"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cc2c(cn1)c(Br)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1.Cl.O.[K+].[OH-]>>O=C(O)c1cc2c(cn1)c(Br)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.O.O=[N+]([O-])c1ccc(CNCCO)cc1.[Na+].[OH-]>>CC(C)(C)OC(=O)N(CCO)Cc1ccc([N+](=O)[O-])cc1",
        "output": "867"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCBr.CN(C)C=O.Clc1cccc(OC2CNCCc3ccccc32)c1.O=C(O)C(=O)O.O=C([O-])O.[Na+]>>CCCN1CCc2ccccc2C(Oc2cccc(Cl)c2)C1",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)S(=O)(=O)Nc1ccc(F)c(C(O)c2c[nH]c3ncc(-c4cccnc4)cc23)c1F.O=C([O-])[O-].O=S([O-])([O-])=S.[K+].[K+].[Na+].[Na+]>>CC(C)S(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4cccnc4)cc23)c1F",
        "output": "852"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN.CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CO.C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@@H]1CC[C@@H](CC(=O)O)CC1.F[P-](F)(F)(F)(F)F>>CCNC(=O)C[C@@H]1CC[C@@H](n2c([C@@H](C)O)nc3cnc4ccsc4c32)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COc1ccc(CBr)c(Cl)c1Cl.CS(C)=O.O.[C-]#N.[Na+]>>COc1ccc(CC#N)c(Cl)c1Cl",
        "output": "39"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC(Nc2cc(-n3c4ccccc4c4c(-c5cnc6ccccc6c5)cccc43)ccc2C#N)CC1.CCO.CS(C)=O.OO.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(Nc2cc(-n3c4ccccc4c4c(-c5cnc6ccccc6c5)cccc43)ccc2C(N)=O)CC1",
        "output": "180"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Nc1ccc2c(c1)=NC(=O)N=2.O=C(O)c1cc2ccccc2cc1O>>O=C1N=c2ccc(NC(=O)c3cc4ccccc4cc3O)cc2=N1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1cn2c3c(c(-c4ccccc4)c(F)cc3c1=O)OCC2C.ClCCl.O=S(=O)(O)Cl>>CCOC(=O)c1cn2c3c(c(-c4ccc(S(=O)(=O)Cl)cc4)c(F)cc3c1=O)OCC2C",
        "output": "182"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Nc1ncc(C(=O)O)cc1OCC1CN(C(=O)Cc2ccc(OC(F)(F)F)cc2)CC1(F)F.[Cl-].[NH4+]>>NC(=O)c1cnc(N)c(OCC2CN(C(=O)Cc3ccc(OC(F)(F)F)cc3)CC2(F)F)c1",
        "output": "704"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C[C@H](C)[C@H](C)Cc2ccc(OCCOCCOCCOCCBr)c(OC)c2)cc1OC.O=C([O-])[O-].O=[N+]([O-])c1c[nH]cn1.[K+].[K+]>>COc1ccc(C[C@H](C)[C@H](C)Cc2ccc(OCCOCCOCCOCCn3cnc([N+](=O)[O-])c3)c(OC)c2)cc1OC",
        "output": "276"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)SCCN1C(=O)NC(C)(C)C1=O.CO.O.[Na+].[OH-]>>CC1(C)NC(=O)N(CCS)C1=O",
        "output": "90"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cn(-c2ccc(F)cc2)nc1C(=O)O.Nc1ccc(Cl)c(NC(=O)c2ccccc2)c1>>Cc1cn(-c2ccc(F)cc2)nc1C(=O)Nc1ccc(Cl)c(NC(=O)c2ccccc2)c1",
        "output": "844"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.NC(=O)CBr.O=C(O)C(F)(F)F.O=S(=O)(c1ccc(F)cc1)[C@@]1(c2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2)CCNC1>>NC(=O)CN1CC[C@](c2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2)(S(=O)(=O)c2ccc(F)cc2)C1",
        "output": "443"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cc(C(=O)O)ccc1F.Cl.N#Cc1ccc(CN)c(O)c1>>Cc1cc(C(=O)NCc2ccc(C#N)cc2O)ccc1F",
        "output": "753"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN1C(=O)C2(CC2)CN(C2CCCC2)c2nc(Nc3ccc(C(=O)O)cc3F)ncc21.CN1CCN(N)CC1.ClCCl.F[B-](F)(F)F>>CN1CCN(NC(=O)c2ccc(Nc3ncc4c(n3)N(C3CCCC3)CC3(CC3)C(=O)N4C)c(F)c2)CC1",
        "output": "55"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(Oc2c(C)cc(-n3ncc(=O)[nH]c3=O)cc2Cl)cc1C(=O)c1ccc(F)cc1.ClB(Cl)Cl.ClCCl>>Cc1cc(-n2ncc(=O)[nH]c2=O)cc(Cl)c1Oc1ccc(O)c(C(=O)c2ccc(F)cc2)c1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)CN(C(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(C)cc2)cc1)c1ccccc1C.CCOC(C)=O.Cl.[BH4-].[Na+]>>Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N(CCO)c3ccccc3C)cc2)cc1",
        "output": "225"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1NCCn2c(-c3ccccn3)ccc21.O=C(O)c1cc2ncc(Cl)cn2n1>>CC1c2ccc(-c3ccccn3)n2CCN1C(=O)c1cc2ncc(Cl)cn2n1",
        "output": "663"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)C1(F)CCN(C2COC2)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCC1(F)CCN(C2COC2)CC1",
        "output": "225"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)c1ccc(CNC(=O)c2c(-c3ccc(F)cc3)c(-c3ccc(F)cc3)c(CC[C@@H](O)C[C@@H](O)CC(=O)O)n2C(C)C)cc1.Cl.[Na+].[OH-]>>CC(C)n1c(CC[C@@H](O)C[C@@H](O)CC(=O)O)c(-c2ccc(F)cc2)c(-c2ccc(F)cc2)c1C(=O)NCc1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CSCCN1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)[O-].Cc1ccccc1.Clc1cc(N2CCOCC2)n2nc(-c3ccc(Br)cc3)cc2n1.O.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Na+].[Pd].[Pd]>>Clc1cc(N2CCOCC2)n2nc(-c3ccc(N4CCSCC4)cc3)cc2n1",
        "output": "294"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CN(C)C=O.COc1cc2ncccc2cc1[N+](=O)[O-].[Cl-].[Fe].[NH4+]>>COc1cc2ncccc2cc1N",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)[C@H](Cc1ccc(C#CCN2CCC(c3ccccc3)CC2)cc1)n1cccc1.COC(=O)[C@H](Cc1ccc(CCCN(C)c2ccccc2)cc1)n1cccc1>>COC(=O)[C@H](Cc1ccc(CCCN2CCC(c3ccccc3)CC2)cc1)n1cccc1",
        "output": "717"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc(C)c(S(=O)(=O)N2CCCCC2COCC(=O)OC(C)(C)C)c(C)c1.ClCCl.O=C(O)C(F)(F)F>>COc1cc(C)c(S(=O)(=O)N2CCCCC2COCC(=O)O)c(C)c1",
        "output": "278"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CO)C(C)C)ccc1OC.CS(=O)(=O)Cl.ClCCl>>COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2COS(C)(=O)=O)C(C)C)ccc1OC",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Nc1cccc(CO)n1.CC(C)(C)[O-].CCOC(C)=O.O.O=[N+]([O-])c1ccc(Cl)nc1.[K+]>>CC(C)(C)OC(=O)Nc1cccc(COc2ccc([N+](=O)[O-])cn2)n1",
        "output": "433"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.Nc1ccc(Br)cc1C(=O)O.O>>Nc1ccc(Br)cc1CO",
        "output": "72"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)N.CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(=O)O.CCN=C=NCCCN(C)C.Cl.ClCCl.On1nnc2ccccc21>>CC(C)(C)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OC(C)(C)C",
        "output": "216"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NC1CC=C(C#Cc2cnccc2Oc2ccc([N+](=O)[O-])cc2F)CC1.CCO.CN(C)C=O.O.[Cl-].[Fe].[NH4+]>>CC(C)(C)OC(=O)NC1CC=C(C#Cc2cnccc2Oc2ccc(N)cc2F)CC1",
        "output": "335"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc2c(CN3CCC[C@H]3C(=O)O)cc3cc4c(cc3c2c1)OCO4.N>>COc1ccc2c(CN3CCC[C@H]3CO)cc3cc4c(cc3c2c1)OCO4",
        "output": "218"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1.ClCCCl.OC1CN(C2CCNCC2)C1.[Na+]>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(N4CC(O)C4)CC3)n(C)c2n1",
        "output": "944"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1ccc(N2CCNCC2)cc1.CCOC(=O)Nc1nc2cc(OC)ccc2nc1OC>>COc1ccc2nc(OC)c(NC(=O)N3CCN(c4ccc(C(C)=O)cc4)CC3)nc2c1",
        "output": "613"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCCN(CCc1c[nH]c2ccccc12)Cc1ccc(S(=O)(=O)n2ccc(/C=C/C(=O)NOC3CCCCO3)c2)cc1.CCCC[N+](CCCC)(CCCC)CCCC.CCN(CC)CC.CCOC(C)=O.O.[F-]>>O=C(/C=C/c1ccn(S(=O)(=O)c2ccc(CN(CCO)CCc3c[nH]c4ccccc34)cc2)c1)NOC1CCCCO1",
        "output": "708"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.Cl.O=C(CCC[C@H](O)c1ccc(F)cc1)N1C(=O)OC[C@@H]1Cc1ccccc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)O[C@@H](CCCC(=O)N1C(=O)OC[C@@H]1Cc1ccccc1)c1ccc(F)cc1",
        "output": "193"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CI.CN(C)P(=O)(N(C)C)N(C)C.COC(=O)COc1cccc(C=CC(=O)c2ccc(C)[nH]c2=O)c1.O.[H-].[Na+]>>COC(=O)COc1cccc(C=CC(=O)c2ccc(C)n(C)c2=O)c1",
        "output": "191"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CI.CN(C)C=O.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C(O)c1ncc(Cl)nc1Cl.O=C([O-])O.[Na+]>>COC(=O)c1ncc(Cl)nc1Cl",
        "output": "415"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)N2CCSC[C@H]2C(=O)O)cc1.ClCCl.OCc1ccc(-c2ccccc2)cc1>>Cc1ccc(S(=O)(=O)N2CCSC[C@H]2C(=O)OCc2ccc(-c3ccccc3)cc2)cc1",
        "output": "536"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=C(C)C(=O)Cl.ClC(Cl)(Cl)Cl.OCCOCCn1c2ccccc2c2ccccc21>>C=C(C)C(=O)OCCOCCn1c2ccccc2c2ccccc21",
        "output": "320"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(Nc1ccc(Cl)cc1)c1cccnc1.ClCCl.O=C([O-])[O-].O=S(=O)(Cl)c1ccccc1.[K+].[K+]>>CC(c1cccnc1)N(c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1",
        "output": "791"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN.O=Cc1ccc(Cl)c([N+](=O)[O-])c1>>CNc1ccc(C=O)cc1[N+](=O)[O-]",
        "output": "304"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.C[C@H]1CC[C@@H](COc2ccc(C(F)(F)F)cn2)NC1.Cc1ccc(-c2ncccn2)c(C(=O)O)n1.ClCCl.F[B-](F)(F)F.O=C([O-])O.[Na+]>>Cc1ccc(-c2ncccn2)c(C(=O)N2C[C@@H](C)CC[C@H]2COc2ccc(C(F)(F)F)cn2)n1",
        "output": "605"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccccc1.CC(C)=O.Cc1c(C)c2c(c(C)c1O)C(=O)C(C)(C)O2.O=C([O-])[O-].[K+].[K+]>>Cc1c(C)c2c(c(C)c1OCc1ccccc1)C(=O)C(C)(C)O2",
        "output": "127"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCCCCC1(CN=[N+]=[N-])c2ccccc2Oc2ccccc21.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCCCCC1(CN)c2ccccc2Oc2ccccc21",
        "output": "89"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCOc1ccc(N2CCN(S(=O)(=O)c3ccc(N)cc3)CC2)cc1.Clc1ccc2c(Cl)ccnc2c1>>CCCOc1ccc(N2CCN(S(=O)(=O)c3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)CC2)cc1",
        "output": "115"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOCCOc1cc2c(cc1OC)-c1cc(=O)c(C(=O)OCC)cn1C(C(C)(C)COC)C2.Cl.[Li+].[OH-]>>CCOCCOc1cc2c(cc1OC)-c1cc(=O)c(C(=O)O)cn1C(C(C)(C)COC)C2",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)c1nccc(Oc2ccc(NC(=O)c3cc(F)cc(N4CCCCC4)c3)c3ccccc23)n1.OC1CCCNC1>>O=C(Nc1ccc(Oc2ccnc(N3CCCC(O)C3)n2)c2ccccc12)c1cc(F)cc(N2CCCCC2)c1",
        "output": "679"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)N.CCOC(C)=O.CN(C)C=O.ClCCCl.Cn1nc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)c2ccc(Cl)cc21.On1nnc2ccccc21>>Cn1nc(-c2cnc3c(n2)c(C(=O)NC(C)(C)C)cn3COCC[Si](C)(C)C)c2ccc(Cl)cc21",
        "output": "737"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCN(CC)CC.CN(Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1)C(=O)CBr.Cl.O[C@@H]1CCCNC1>>CN(Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1)C(=O)CN1CCC[C@@H](O)C1",
        "output": "443"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOP(=O)(OCC)c1cc(Oc2ccc(C(F)(F)F)cc2[N+](=O)[O-])ccc1[N+](=O)[O-].Cl>>O=[N+]([O-])c1cc(C(F)(F)F)ccc1Oc1ccc([N+](=O)[O-])c(P(=O)(O)O)c1",
        "output": "535"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C1C2CNCC21.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F.O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1>>CCOC(=O)C1C2CN(C(=O)c3ccc(N4CC(F)(F)C4)c(OCC4CC4)n3)CC21",
        "output": "605"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.O.O.O=S([O-])S(=O)[O-].O=[N+]([O-])c1ccc2oc(N3CCOCC3)nc2c1.[Na+].[Na+]>>Nc1ccc2oc(N3CCOCC3)nc2c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.ClCCl.O.O=Cc1ccc(CBr)cc1.[N-]=[N+]=[N-].[Na+]>>[N-]=[N+]=NCc1ccc(C=O)cc1",
        "output": "643"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CCc1cc(C(=O)OC)c(=O)[nH]c1-c1ccc(N2CCC(OCc3ccccc3)C2)cc1.CO.[Pd]>>CCc1cc(C(=O)OC)c(=O)[nH]c1-c1ccc(N2CCC(O)C2)cc1",
        "output": "178"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(OC(C)=O)[C@@H]1C[C@H](O)[C@H](n2c(=O)sc3c(=O)[nH]c(N)nc32)O1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CCC(OC(C)=O)[C@@H]1C[C@H](OS(=O)(=O)C(F)(F)F)[C@H](n2c(=O)sc3c(=O)[nH]c(N)nc32)O1",
        "output": "582"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "NCC1(c2cnc(C(F)(F)F)nc2)CCC(F)(F)CC1.O=C(O)c1cccc(C(F)(F)F)c1Cl>>O=C(NCC1(c2cnc(C(F)(F)F)nc2)CCC(F)(F)CC1)c1cccc(C(F)(F)F)c1Cl",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1C(=O)CCN(C2CCCC2)c2nc(Nc3cc(F)c(C(=O)OC(C)(C)C)cc3Cl)ncc21.ClCCl.O=C(O)C(F)(F)F>>CN1C(=O)CCN(C2CCCC2)c2nc(Nc3cc(F)c(C(=O)O)cc3Cl)ncc21",
        "output": "752"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCP(=O)=O.CCN(C(C)C)C(C)C.COC(=O)c1cnn(C)c1C(=O)O.Nc1ccn2nc(-c3ccccc3)nc2c1.O=C([O-])O.[Na+]>>COC(=O)c1cnn(C)c1C(=O)Nc1ccn2nc(-c3ccccc3)nc2c1",
        "output": "844"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)CCN1C(=O)C(C)(C)Oc2c(C)cc(C)cc21.[Li+].[OH-]>>Cc1cc(C)c2c(c1)N(CCC(=O)O)C(=O)C(C)(C)O2",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.COS(=O)(=O)OC.Cc1ccc2c(c1O)CCC2=O.O.O=C([O-])[O-].[K+].[K+]>>COc1c(C)ccc2c1CCC2=O",
        "output": "317"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#CCOc1ncnc(Cl)c1Cl.CC1CNCC(C)C1.CCO>>CC#CCOc1ncnc(N2CC(C)CC(C)C2)c1Cl",
        "output": "296"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.Br.Br.CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCNC4)n[nH]c2c1.O=Cc1cccc(O)c1>>CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3cccc(O)c3)C4)n[nH]c2c1",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C(=O)c1ccccc1)[C@@H](Cc1ccccc1)[C@H](O)CN.Cl.ClCCCl.ClCCl.O=C(O)c1ccccn1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CN(C(=O)c1ccccc1)[C@@H](Cc1ccccc1)[C@H](O)CNC(=O)c1ccccn1",
        "output": "137"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCc1nc2cc(NC(=O)CCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCCCc1nc2cc(NC(=O)CCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.Nc1cccc2ccc(O)cc12.O=CO>>O=CNc1cccc2ccc(O)cc12",
        "output": "27"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CCO.CCOCC.I.N=C(NN)NCc1ccco1.O.O=Cc1c(Cl)cccc1Cl.[Na+].[OH-]>>N=C(NCc1ccco1)NN=Cc1c(Cl)cccc1Cl",
        "output": "167"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCc1nc(C)cc(=O)[nH]1.O=Cc1ccc(OCCBr)cc1.[Br-].[H-].[Li+].[Na+]>>CCc1nc(C)cc(=O)n1CCOc1ccc(C=O)cc1",
        "output": "327"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@H](N)CC1.CC(C)O.CCN(C(C)C)C(C)C.Cc1cnc(Cl)nc1N(C)C>>Cc1cnc(N[C@H]2CC[C@@H](NC(=O)OC(C)(C)C)CC2)nc1N(C)C",
        "output": "544"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)CN=S(C)(=O)c1ccc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)cc1.CS(C)=O.[BH4-].[Na+]>>CS(=O)(=NCCO)c1ccc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)cc1",
        "output": "225"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1cc(C)c(S(=O)(=O)N2CCC(=O)CC2)c(C)c1.ClCCl.N#CCCC1CCNCC1.[Na+]>>Cc1cc(C)c(S(=O)(=O)N2CCC(N3CCC(CCC#N)CC3)CC2)c(C)c1",
        "output": "187"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCc2cc(C(=O)N3CC(N4CCN(C(=O)c5nccs5)CC4)C3)ccc2C1.ClCCl.O=C(O)C(F)(F)F>>O=C(c1ccc2c(c1)CCNC2)N1CC(N2CCN(C(=O)c3nccs3)CC2)C1",
        "output": "887"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CN.Cc1ncc(C(=O)O)c(C)n1>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cnc(C)nc1C",
        "output": "737"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CS(=O)(=O)Cl.Cc1cc(C)nc(C)c1.O.O=c1[nH]nc(-c2cccc(CO)c2)c2ccccc12.[Cl-].[Li+]>>O=c1[nH]nc(-c2cccc(CCl)c2)c2ccccc12",
        "output": "713"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCCl.Nc1ccccn1.O=C(O)CCC1=CCCN(Cc2ccccc2)C1=O>>O=C(CCC1=CCCN(Cc2ccccc2)C1=O)Nc1ccccn1",
        "output": "368"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)C(=COCF)c1ccccc1C.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)C(=COCF)c1ccccc1CBr",
        "output": "29"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CCCCN1CCN2CCN(CCCC)P1N(CCCC)CC2.Fc1ccc(-n2ncnc2-c2cc3c(s2)-c2nc(Cl)ccc2OCC3)c(F)c1.NCCc1ccccc1.[Pd+2]>>Fc1ccc(-n2ncnc2-c2cc3c(s2)-c2nc(NCCc4ccccc4)ccc2OCC3)c(F)c1",
        "output": "70"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CO.COc1ccccc1Oc1c(NS(=O)(=O)c2ncc(C)s2)nc(-c2ccnc(C(=O)O)c2)nc1OC.F[P-](F)(F)(F)(F)F>>COC(=O)c1cc(-c2nc(NS(=O)(=O)c3ncc(C)s3)c(Oc3ccccc3OC)c(OC)n2)ccn1",
        "output": "331"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(SCC(=O)NCCc2ccc([N+](=O)[O-])cc2)cc1.CCO.Cl[Sn]Cl.O.O>>CC(C)(C)OC(=O)Nc1ccc(SCC(=O)NCCc2ccc(N)cc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "B.C1CCOC1.C1CCOC1.Cl.O.O=C(O)CCc1cccc(Cl)c1>>OCCCc1cccc(Cl)c1",
        "output": "231"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)N/C(=N/C(=O)c1ccc(C(F)(F)F)cc1)Nc1cc(-c2ccc(OCc3ccccc3)cc2)n[nH]1.CO.[H][H].[Pd]>>CC(C)(C)N/C(=N/C(=O)c1ccc(C(F)(F)F)cc1)Nc1cc(-c2ccc(O)cc2)n[nH]1",
        "output": "23"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CCNCC.Cc1ccccc1.O=c1c2ccccc2nc(-c2cncc(Br)c2)n1-c1ccc(Cl)cc1.[Fe+2].[Na+].[Pd+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCN(CC)c1cncc(-c2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1",
        "output": "597"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(NC(=O)OC(C)(C)C)CCN(C(=O)c2ccc(-c3cn4c(-c5ccc(C#N)cc5)cnc4cn3)cc2F)CC1.ClCCl.O=C(O)C(F)(F)F>>CC1(N)CCN(C(=O)c2ccc(-c3cn4c(-c5ccc(C#N)cc5)cnc4cn3)cc2F)CC1",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=O.CC(=O)O.CO.COc1cc(N2CCNCC2)ccc1Br.[BH3-]C#N.[Na+]>>COc1cc(N2CCN(C)CC2)ccc1Br",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(C(=O)O)cc1S(=O)(=O)Cl.Cc1ccc(S(=O)(=O)CCO)cc1.O=S(Cl)Cl>>Cc1ccc(S(=O)(=O)CCOC(=O)c2ccc(C)c(S(=O)(=O)Cl)c2)cc1",
        "output": "33"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc([N+](=O)[O-])cn1.O=[Pt+3]>>NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc(N)cn1",
        "output": "269"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(=O)[O-].CCC(N)c1nn2cccc2c(=O)n1Cc1ccccc1.O=C1CCCC1.[Na+].[Na+]>>CCC(NC1CCCC1)c1nn2cccc2c(=O)n1Cc1ccccc1",
        "output": "236"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(Oc2cnc(NC(=O)C(O[C@@H]3CCOC3)c3ccc(S(=O)(=O)C4CC4)cc3)s2)ccc1C.[Li+].[OH-]>>Cc1ccc(Oc2cnc(NC(=O)C(O[C@@H]3CCOC3)c3ccc(S(=O)(=O)C4CC4)cc3)s2)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CO.Cl.Clc1ccc(-c2cc(CCCOC3CCCCO3)ncn2)cc1.O=C([O-])O.[Na+]>>OCCCc1cc(-c2ccc(Cl)cc2)ncn1",
        "output": "543"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)C(=O)[C@@H]1C=C2c3cccc4c3c(cn4CCCN)C[C@H]2N(C)C1.CCN(CC)CC.O=C(Cl)c1ccc(-c2ccc(C(=O)ON3C(=O)CCC3=O)cc2)cc1>>CCN(CC)C(=O)[C@@H]1C=C2c3cccc4c3c(cn4CCCNC(=O)c3ccc(-c4ccc(C(=O)ON5C(=O)CCC5=O)cc4)cc3)C[C@H]2N(C)C1",
        "output": "271"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.FC(F)(F)c1ccc(CBr)c(C(F)(F)F)c1.O.O=C([O-])[O-].O=Cc1ccc(O)c(C(F)(F)F)c1.[K+].[K+]>>O=Cc1ccc(OCc2ccc(C(F)(F)F)cc2C(F)(F)F)c(C(F)(F)F)c1",
        "output": "127"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "N#Cc1nccc2[nH]c(=O)c(-c3ccccc3)cc12.O=P(Cl)(Cl)Cl>>N#Cc1nccc2nc(Cl)c(-c3ccccc3)cc12",
        "output": "100"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC#N.CCc1cc(Br)c(NS(=O)(=O)c2ccccc2F)c(C(=O)OC)c1OC.O.[Li+].[OH-]>>CCc1cc(Br)c(NS(=O)(=O)c2ccccc2F)c(C(=O)O)c1OC",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CC[C@H](N)c1cc2cccc(F)c2c(=O)n1-c1ccccc1.Nc1ncnc(Cl)c1-c1ccon1>>CC[C@H](Nc1ncnc(N)c1-c1ccon1)c1cc2cccc(F)c2c(=O)n1-c1ccccc1",
        "output": "110"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.NC(=O)c1cc2c(O)cccc2[nH]1.[Na+].[OH-].c1ccc(C(c2ccccc2)N2CC(OCC3CO3)C2)cc1>>NC(=O)c1cc2c(OCC(O)COC3CN(C(c4ccccc4)c4ccccc4)C3)cccc2[nH]1",
        "output": "277"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].O=[N+]([O-])c1c(C(O)c2ccc(C(F)(F)F)cc2)ccc2cccnc12.c1cc[nH+]cc1.c1cc[nH+]cc1>>O=C(c1ccc(C(F)(F)F)cc1)c1ccc2cccnc2c1[N+](=O)[O-]",
        "output": "59"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc(-c2nn(CCO)c3ncnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C.CS(=O)(=O)Cl.c1ccncc1>>COc1cc(-c2nn(CCOS(C)(=O)=O)c3ncnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCCCBr.CCOC(C)=O.CN(C)C=O.COC(=O)c1cc(-c2cc(Sc3cccc(O)c3)nc(N)n2)c(C)cc1OC.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)c1cc(-c2cc(Sc3cccc(OCCCNC(=O)OC(C)(C)C)c3)nc(N)n2)c(C)cc1OC",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOc1nc2cccc(C(=O)NC(CSC(C)=O)CC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1.CO.[Na+].[OH-]>>CCOc1nc2cccc(C(=O)NC(CS)CC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1",
        "output": "90"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(Cl)nn1.OB(O)c1ccccc1>>Cc1ccc(-c2ccccc2)nn1",
        "output": "866"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCBr.CN(C)C=O.COc1cc(OC)nc(OC(Cc2c(Cl)cccc2Cl)C(=O)O)n1.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C(Cc1c(Cl)cccc1Cl)Oc1nc(OC)cc(OC)n1",
        "output": "416"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCN(C2CCNCC2)CC1.Clc1ccc(-c2cccnc2)nn1>>c1cncc(-c2ccc(N3CCC(N4CCCCC4)CC3)nn2)c1",
        "output": "406"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(CCn1ccc(OCc2ccccc2)cc1=O)(C(=O)NOC1CCCCO1)S(C)(=O)=O.CO.Cl.ClCCl>>CC(CCn1ccc(OCc2ccccc2)cc1=O)(C(=O)NO)S(C)(=O)=O",
        "output": "915"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(Cc1ccc([N+](=O)[O-])cc1)(C(=O)c1ccc(F)cc1)N(C)C.CCO.[H][H].[Pd]>>CCC(Cc1ccc(N)cc1)(C(=O)c1ccc(F)cc1)N(C)C",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCCCCCCCCCCCCCCI.CN(C)C=O.Cl.Oc1ccc(O)cc1.[H-].[Na+]>>CCCCCCCCCCCCCCCCOc1ccc(O)cc1",
        "output": "198"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1cccnc1Nc1ccc(Cl)cc1.CO.COc1cc(C=O)cc(OC)c1OC.COc1ccc(Nc2ncccc2C=CC(=O)c2cc(OC)c(OC)c(OC)c2)cc1.Cl>>COc1cc(C=CC(=O)c2cccnc2Nc2ccc(Cl)cc2)cc(OC)c1OC",
        "output": "295"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COc1cccc(NC(C(=O)c2cn(S(=O)(=O)C3CCN(C(=O)OCc4ccccc4)CC3)c3ccccc23)c2ccccc2)c1.O=C[O-].[NH4+].[OH-].[OH-].[Pd+2]>>COc1cccc(NC(C(=O)c2cn(S(=O)(=O)C3CCNCC3)c3ccccc23)c2ccccc2)c1",
        "output": "428"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1C(=O)CCN(C2CCCC2)c2nc(Cl)ncc21.COc1cc(C(=O)O)ccc1N.O=C(O)C(F)(F)F>>COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CCC(=O)N2C",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)[C@H](C)COCOCc1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>C[C@H](CO)COCOCc1ccccc1",
        "output": "343"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCO.COC(=O)Cc1cn(C)nc1OCc1ccnc(OCc2nc(-c3ccccc3)oc2C)c1.Cl.[Na+].[OH-]>>Cc1oc(-c2ccccc2)nc1COc1cc(COc2nn(C)cc2CC(=O)O)ccn1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Nc1ccc(N)c(NCc2ccccc2)c1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1cc(C(=O)O)cn(C)c1=O.F[P-](F)(F)(F)(F)F.O>>Cc1cc(C(=O)Nc2ccc(NC(=O)OC(C)(C)C)cc2NCc2ccccc2)cn(C)c1=O",
        "output": "739"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)CBr.ClCCl.O.OCCCOCCCCCOCc1ccccc1.[Na+].[OH-]>>CC(C)(C)OC(=O)COCCCOCCCCCOCc1ccccc1",
        "output": "669"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C=CCCC(C)C[C@@H](COC)[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)OC.CO.O.[Li+].[OH-]>>C=CCCC(C)C[C@@H](COC)[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1cccc(Nc2c(C(N)=O)cnc3cc(-c4cnc(OC)nc4OC)ccc23)c1.[Na+].[OH-]>>COc1ncc(-c2ccc3c(Nc4cccc(C(=O)O)c4)c(C(N)=O)cnc3c2)c(OC)n1",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(CNC(=O)OC(C)(C)C)CCN(Cc2ccccc2)CC1.CCO.[OH-].[OH-].[Pd+2]>>CC1(CNC(=O)OC(C)(C)C)CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)CN(c1ccc2c(c1)CCCN2C(=O)CCc1ccc(C(=N)N)cc1)S(=O)(=O)c1ccccc1.Cl.[Na+].[OH-]>>N=C(N)c1ccc(CCC(=O)N2CCCc3cc(N(CC(=O)O)S(=O)(=O)c4ccccc4)ccc32)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC=O.Cl.ClCCl.Cn1c2c(c3ccc(-n4ccc(OCc5ccccc5)cc4=O)cc31)CNCCC2.O=C([O-])O.[Na+]>>CCN1CCCc2c(c3ccc(-n4ccc(OCc5ccccc5)cc4=O)cc3n2C)C1",
        "output": "484"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.Cl.NCc1csc2c1S(=O)(=O)N=C(c1c(O)c3ccccc3n(Cc3ccccc3)c1=O)N2.O=C(O)CO>>O=C(CO)NCc1csc2c1S(=O)(=O)N=C(c1c(O)c3ccccc3n(Cc3ccccc3)c1=O)N2",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)O.N#Cc1cc(C=O)ccc1F.O.[Na+].[O-][Cl+][O-]>>N#Cc1cc(C(=O)O)ccc1F",
        "output": "384"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)N.CO.COC(=O)c1cccc(Nc2cc(-c3cc(C(=O)NC(C)(C)C)cc(N4CCN(C(=O)OC(C)(C)C)CC4)n3)ccn2)c1C.Cc1ccccc1>>Cc1c(Nc2cc(-c3cc(C(=O)NC(C)(C)C)cc(N4CCN(C(=O)OC(C)(C)C)CC4)n3)ccn2)cccc1C(=O)NC(C)C",
        "output": "338"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(N3CCOC(C)(c4ccc(Cl)cc4)C3)sc2c1-c1ccc(Cl)cc1.CO.[Na+].[OH-]>>Cc1cc2nc(N3CCOC(C)(c4ccc(Cl)cc4)C3)sc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)CCC(O)c1ccccc1.CS(C)=O.Cl.O=[N+]([O-])c1cccc(F)c1.[H-].[Na+]>>CN(C)CCC(Oc1cccc([N+](=O)[O-])c1)c1ccccc1",
        "output": "485"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1nc2cnc3cc(Oc4ccc([N+](=O)[O-])cc4)ccc3c2n1CC(C)C.Cc1ccc(S(=O)(=O)Cl)cc1.ClC(Cl)Cl.ClCCl.O=C(OO)c1cccc(Cl)c1.[NH4+].[OH-]>>CCCc1nc2c(N)nc3cc(Oc4ccc([N+](=O)[O-])cc4)ccc3c2n1CC(C)C",
        "output": "959"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCC1CCN(c2nc(Nc3ccc(C(N)=O)cc3)ncc2F)CC1.O=C(O)C(F)(F)F>>NCC1CCN(c2nc(Nc3ccc(C(N)=O)cc3)ncc2F)CC1",
        "output": "538"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)c1cc(C(=O)O)cc(C(C)(C)C)c1.Cl.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(C)c1cc(CO)cc(C(C)(C)C)c1",
        "output": "72"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)c1ccc(C(=O)O)cc1.CC(C)N1CCNCC1.CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.Cl.Cl.Cl.On1nnc2ccccc21>>CC(=O)c1ccc(C(=O)N2CCN(C(C)C)CC2)cc1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.Cc1ccc(S(=O)(=O)OCCCCc2c[nH]c3ccc(F)cc23)cc1.O=C([O-])[O-].O=c1c2ccccc2ccn1-c1ccc(N2CCNCC2)cc1.[I-].[K+].[K+].[K+]>>O=c1c2ccccc2ccn1-c1ccc(N2CCN(CCCCc3c[nH]c4ccc(F)cc34)CC2)cc1",
        "output": "429"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccccc1S(=O)(=O)O.O.O=C1CCC2CC1CCC2=O.OCCO>>O=C1CCC2CC1CCC21OCCO1",
        "output": "265"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.CCN(CC)CC.CCNc1cccc(OCc2ccccc2)c1[N+](=O)[O-].ClCCl>>CCN(C(C)=O)c1cccc(OCc2ccccc2)c1[N+](=O)[O-]",
        "output": "160"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)c1ccccc1.CC[O-].CC[O-].CC[O-].CC[O-].CN.CO.O.[BH4-].[Na+].[Ti+4]>>CNC(C)c1ccccc1",
        "output": "693"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.O=[N+]([O-])c1ccc(Oc2ccnc3cc(-c4ccc(CN5CCCC5)cc4)sc23)c(F)c1.[BH4-].[Na+]>>Nc1ccc(Oc2ccnc3cc(-c4ccc(CN5CCCC5)cc4)sc23)c(F)c1",
        "output": "335"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1cc(-c2cc[nH]n2)c2nc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)n2n1.Cl.O.[Na+].[OH-]>>NC1(c2ccc(-c3nc4c(-c5cc[nH]n5)cc(C(=O)O)nn4c3-c3ccccc3)cc2)CCC1",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.C[Si](C)(C)CCOCn1ccc2c(C(O)C3CCCN(Cc4ccccc4)C3)ncnc21.ClCCl>>C[Si](C)(C)CCOCn1ccc2c(C(=O)C3CCCN(Cc4ccccc4)C3)ncnc21",
        "output": "456"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCOC(=O)c1cnc(SC)[nH]c1=O.Cl.[Na+].[OH-]>>CSc1ncc(C(=O)O)c(=O)[nH]1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1nc(N)ccc1Cl.O=S(=O)(O)O.O=[N+]([O-])O.[Na+].[OH-]>>Cc1nc(N)c([N+](=O)[O-])cc1Cl",
        "output": "328"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cc(O)nc(C(C)C)n1.Cc1ccccc1.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>Cc1cc(Cl)nc(C(C)C)n1",
        "output": "25"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCC[NH2+]CCCl.ClCCl.[Cl-]>>CC(C)(C)OC(=O)N(CCCl)CCCl",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)NCCCS(=O)(=O)Cl.CC(C)C(=O)OCC(C)(C)CO.CN(C)c1ccncc1.ClCCl.c1ccncc1>>CC(=O)NCCCS(=O)(=O)OCC(C)(C)COC(=O)C(C)C",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.N[C@H]1CCC[C@H]1CO.O=C(NCc1ccc(F)cc1F)C1CCC2COC3Cn4ccc(=O)c(O)c4C(=O)N3C21.O=C(NCc1ccc(F)cc1F)c1cn2c(c(OCc3ccccc3)c1=O)C(=O)N1C(C2)OCC2CCCC21.[Pd]>>O=C(NCc1ccc(F)cc1F)c1cn2c(c(O)c1=O)C(=O)N1C(C2)OCC2CCCC21",
        "output": "264"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(O)C1CCN(Cc2ccc3nc(Cl)nc(N4CCOCC4)c3n2)CC1.Cc1nc2ccccc2[nH]1>>Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(C(C)(C)O)CC3)ccc2n1",
        "output": "788"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)N=NC(=O)OCC.CN(C)CCCO.COc1ccc(-c2[nH]c(-c3ccc(O)cc3)nc2C(=O)Nc2nccs2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(-c2[nH]c(-c3ccc(OCCCN(C)C)cc3)nc2C(=O)Nc2nccs2)cc1",
        "output": "478"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(=O)COc1ccc(CCN)cc1.CCOC(C)=O.CCOP(=O)(C#N)OCC.CN(C)C=O.COc1cccc([C@H]2O[C@H](CC(=O)O)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC.Cl>>CCOC(=O)COc1ccc(CCNC(=O)C[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3N(CC(C)(C)CO)C2=O)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CC(=O)[O-].COC(=O)c1n[nH]cc1[N+](=O)[O-].ClCCl.OB(O)c1ccccc1.[Cu+2].c1ccncc1>>COC(=O)c1nn(-c2ccccc2)cc1[N+](=O)[O-]",
        "output": "925"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)O)CC2)nc1CN1CCCCC1=O.NS(=O)(=O)Cc1ccc(SC(F)(F)F)cc1>>CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccc(SC(F)(F)F)cc3)CC2)nc1CN1CCCCC1=O",
        "output": "644"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(O)c1c(F)cccc1F.O=S(=O)(O)Cl>>O=C(O)c1c(F)ccc(S(=O)(=O)Cl)c1F",
        "output": "357"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.NN.O.O=C(O)c1ccccc1I.O=C(n1ccnc1)n1ccnc1>>NNC(=O)c1ccccc1I",
        "output": "55"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.COC(=O)[C@H](COC1CCC1)O[Si](C)(C)C(C)(C)C.[I-].[Li+]>>CC(C)(C)[Si](C)(C)O[C@@H](COC1CCC1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)Cc1cnnn1-c1cccc(C(=O)CC(=O)OC(C)(C)C)c1.CN(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1C(F)(F)F>>CN(C)Cc1cnnn1-c1cccc(C(=O)CC(=O)Nc2cc(C(F)(F)F)c(N(C)C)cc2NC(=O)OC(C)(C)C)c1",
        "output": "929"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)Cc1ccc(Oc2ccc3c(cc(C)n3C)c2NS(=O)(=O)c2ccc(Cl)cc2Cl)c(OC)c1.CO.Cl.O.[Li+].[OH-]>>COc1cc(CC(=O)O)ccc1Oc1ccc2c(cc(C)n2C)c1NS(=O)(=O)c1ccc(Cl)cc1Cl",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1c(O)cccc1O.ClCCl.O=C(Cl)c1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>Cc1c(O)ccc(C(=O)c2ccccc2)c1O",
        "output": "61"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)N=C=O.Cc1ccccc1.Nc1ccc([N+](=O)[O-])cc1O>>CC(C)NC(=O)Nc1ccc([N+](=O)[O-])cc1O",
        "output": "176"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COCCCN.Cc1nc2c3c(c(C(=O)O)cc2n1C)CCC1(Cc2ccccc2C1)N3>>COCCCNC(=O)c1cc2c(nc(C)n2C)c2c1CCC1(Cc3ccccc3C1)N2",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.Cc1nc(C)c(Br)c(O)c1Br.ClC(Cl)Cl.O=P(Cl)(Cl)Cl>>Cc1nc(C)c(Br)c(Cl)c1Br",
        "output": "177"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CO[C@H](C)C(=O)O.ClCCl.Nc1c[nH]c2ncc(F)c(F)c12.O.O=C1OCCN1P(=O)(Cl)N1CCOC1=O.[Li+].[OH-]>>CO[C@H](C)C(=O)Nc1c[nH]c2ncc(F)c(F)c12",
        "output": "724"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O.O=C(O)C1CCCNC1.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCCC(C(=O)O)C1",
        "output": "694"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.O=C(O)c1cc2ncc(Cl)cn2n1.c1nc2c(s1)CCNCC2>>O=C(c1cc2ncc(Cl)cn2n1)N1CCc2ncsc2CC1",
        "output": "663"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cnc(N2CCNCC2)c(C)c1.O=C(O)c1ccc(Br)cc1[N+](=O)[O-]>>Cc1cnc(N2CCN(C(=O)c3ccc(Br)cc3[N+](=O)[O-])CC2)c(C)c1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.CCOC(C)=O.CO.COc1ccc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)nc1.ClCCl>>O=S(=O)(Nc1ccc2c(c1)B(O)OC2)c1ccc(O)cn1",
        "output": "424"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CC1CCC(CO)CC1.Cc1ccccc1.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>C=CC1CCC(C=O)CC1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1cncc(N2CCOCC2)c1.C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2cncc(N3CCOCC3)c2)OC1(C)C",
        "output": "943"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COc1cccc(-c2nc(=O)n(C(C)C)c3cc(C(=O)O)ccc23)c1.Cl>>COC(=O)c1ccc2c(-c3cccc(OC)c3)nc(=O)n(C(C)C)c2c1",
        "output": "33"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.COc1cccc(C2CCN(c3cnnc(NN)c3Cl)CC2)c1.ClCCl.O.O=C(O)CC1CC1.O=C([O-])O.O=S(Cl)Cl.[Na+]>>COc1cccc(C2CCN(c3cnnc(NNC(=O)CC4CC4)c3Cl)CC2)c1",
        "output": "459"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.Cc1cc(-c2ncccc2-c2ccnc(Cl)n2)ccc1F.N.O>>Cc1cc(-c2ncccc2-c2ccnc(N)n2)ccc1F",
        "output": "312"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cc(Br)cnc1C.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cc1cc(Br)c[n+]([O-])c1C",
        "output": "262"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C(C(=O)OCC)c1ccc(-c2ccc([N+](=O)[O-])cc2)cc1.COC(=O)C1CCC(c2ccc(N)cc2)C1>>CCOC(=O)C(C(=O)OCC)c1ccc(-c2ccc(N)cc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(-c2cn(C3CCCC3)c3ncnc(N)c23)ccc1N.ClCCl.O=S(=O)(Cl)Cc1ccccc1.c1ccncc1>>COc1cc(-c2cn(C3CCCC3)c3ncnc(N)c23)ccc1NS(=O)(=O)Cc1ccccc1",
        "output": "194"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "B.C1CCOC1.COC(=O)c1cccc(-c2cccc(NC(=O)CNC(=O)OC(C)(C)C)c2)c1>>COC(=O)c1cccc(-c2cccc(NCCNC(=O)OC(C)(C)C)c2)c1",
        "output": "112"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cc(C)n(C(OCc2ccc(Cl)cc2)c2cccc(Cl)c2)n1.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>Cc1cc(CO)nn1C(OCc1ccc(Cl)cc1)c1cccc(Cl)c1",
        "output": "391"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)COCCOC(COc1cccc(C(=O)O)c1)N=[N+]=[N-].CCOC(C)=O.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCCNC(=O)C(F)(F)F.O=C(O)C(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CCOC(=O)COCCOC(COc1cccc(C(=O)NCCNC(=O)C(F)(F)F)c1)N=[N+]=[N-]",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CCN=C=NCCCN(C)C.Cl.NCc1ccccc1.O.O=C(O)c1ccc2ncccc2c1.c1ccncc1>>O=C(NCc1ccccc1)c1ccc2ncccc2c1",
        "output": "753"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nc1ccc2[nH]ccc2c1.O=C(Cl)C1CC1>>O=C(Nc1ccc2[nH]ccc2c1)C1CC1",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCC.FC(F)(F)Oc1ccc(Br)c(Cl)c1.O=C=O.[Li]CCCC>>O=C(O)c1ccc(OC(F)(F)F)cc1Cl",
        "output": "654"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(C)=O.C[S-].FC(F)(F)c1cc(Br)cnc1Cl.[Na+]>>CSc1ncc(Br)cc1C(F)(F)F",
        "output": "333"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Clc1ccccc1CN1CCCNCC1.FC(F)(F)c1nnc2ccc(Cl)nn12>>FC(F)(F)c1nnc2ccc(N3CCCN(Cc4ccccc4Cl)CC3)nn12",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CCc1ccccc1.CCN(CC)CC.CN(C)C=O.COC(=O)c1ccc(Cn2ccc3ccc(Br)nc3c2=O)cc1.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1ccc(Cn2ccc3ccc(C#CCc4ccccc4)nc3c2=O)cc1",
        "output": "777"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CN1C(=O)[C@@H](NC(CCCCN2CCCCC2)C(=O)OCC)CSc2ccccc21.CO.Cl.Cl.[Na+].[OH-]>>O=C(O)CN1C(=O)[C@@H](NC(CCCCN2CCCCC2)C(=O)O)CSc2ccccc21",
        "output": "255"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCC(N)CC1.Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3O[C@H]3CCOC3)c12>>Cc1c(C(=O)NC2CCN(C)CC2)sc2ncnc(Nc3ccc(F)cc3O[C@H]3CCOC3)c12",
        "output": "736"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C(O)c1cn(C2CC2)c2nc3cc(Cl)c(F)cc3cc2c1=O.OCCN1CCNCC1.c1ccncc1>>O=C(O)c1cn(C2CC2)c2nc3cc(N4CCN(CCO)CC4)c(F)cc3cc2c1=O",
        "output": "280"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cc1ccc(Cn2c(=O)n(Cc3ccc(C(=O)O)cc3)c(=O)c3ccccc32)cc1.Cl.ClCCl.NCC1COC1>>Cc1ccc(Cn2c(=O)n(Cc3ccc(C(=O)NCC4COC4)cc3)c(=O)c3ccccc32)cc1",
        "output": "821"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CC(C)(C)OC(=O)NC1CCNCC1.N#CCCBr>>CC(C)(C)OC(=O)NC1CCN(CCC#N)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.CI.CN(C)C=O.OC(c1ccco1)c1ccccc1Cl.[H-].[Na+]>>COC(c1ccco1)c1ccccc1Cl",
        "output": "140"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.C[Si](C)(C)[N-][Si](C)(C)C.O=[N+]([O-])c1cc(F)ccc1F.OCc1cccnc1.[Li+]>>O=[N+]([O-])c1cc(F)ccc1OCc1cccnc1",
        "output": "485"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCOC(=O)CN1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1.CO.O.O.O.[Li+].[OH-]>>O=C(O)CN1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCN(c2cc3[nH]c(Nc4ccccc4C(F)(F)F)nc3cc2C(=O)Nc2ccc3cn[nH]c3c2)CC1.Cl>>O=C(Nc1ccc2cn[nH]c2c1)c1cc2nc(Nc3ccccc3C(F)(F)F)[nH]c2cc1N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN.COC(=O)c1nc(SC)ncc1Br.Cl.ClCCl.O=C(OO)c1cccc(Cl)c1>>CNc1ncc(Br)c(C(=O)OC)n1",
        "output": "101"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(=O)(=O)CCCc1c(CO)n(S(=O)(=O)c2ccccc2)c2cc(Cl)ccc12.CS(=O)(=O)Cl.ClCCl.O=C([O-])O.[Na+]>>CS(=O)(=O)CCCc1c(COS(C)(=O)=O)n(S(=O)(=O)c2ccccc2)c2cc(Cl)ccc12",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(-c2ccc(C=O)c3ccccc23)cc1F.Cl.O.c1ccncc1>>O=Cc1ccc(-c2ccc(O)c(F)c2)c2ccccc12",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)CC(=O)Cl.CC(C)CC(NC(=O)OC(C)(C)C)C(O)CN.CCN(CC)CC.Cl.ClC(Cl)Cl>>CC(C)CC(=O)NCC(O)C(CC(C)C)NC(=O)OC(C)(C)C",
        "output": "45"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1cc(C2CC2)on1.Cl.[Na+].[OH-]>>O=C(O)c1cc(C2CC2)on1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1CCC(CN)C1.Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)O)cn2)c1O.O=C(O)C(F)(F)F>>Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)NCC3CCN(C)C3)cn2)c1O",
        "output": "674"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCN(CCC(O)c3ccc(F)cc3)CC2)c1.Oc1ccc(F)c(F)c1>>CC(C)C(=O)Nc1cccc(C2CCN(CCC(Oc3ccc(F)c(F)c3)c3ccc(F)cc3)CC2)c1",
        "output": "342"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=C(C)C(=O)Cl.CCOCC.OCCCC(O)(C(F)(F)F)C(F)(F)F.[Li]CCCC>>C=C(C)C(=O)OCCCC(O)(C(F)(F)F)C(F)(F)F",
        "output": "320"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCI.CCc1cc(O)c(OCc2ccccc2)c(OCCCCCC(C)(C)C#N)c1>>CCOc1cc(CC)cc(OCCCCCC(C)(C)C#N)c1OCc1ccccc1",
        "output": "198"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O=C(NCC(=O)N1CCCCCC1)OCc1ccccc1>>NCC(=O)N1CCCCCC1",
        "output": "128"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)CC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.O=[N+]([O-])c1ccc(O)cc1F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc([N+](=O)[O-])c(F)c2)CC1",
        "output": "846"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCC1CO1.CCO.COc1cc(F)c(F)cc1O.Cl.O.[K+].[OH-]>>COc1cc(F)c(F)cc1OCC1CO1",
        "output": "18"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)N=C=NC(C)C.CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)O.CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO.On1nnc2ccccc21>>CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C(=O)Cc1ccc(F)cc1)C1CNCC1c1ccc(Cl)c(Cl)c1.O=C(O)C1CCN(CC2CC2)CC1>>CN(C(=O)Cc1ccc(F)cc1)C1CN(C(=O)C2CCN(CC3CC3)CC2)CC1c1ccc(Cl)c(Cl)c1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1ccc(C(=O)O)cc1.CCN(CC)CC.C[n+]1ccccc1Cl.Cc1ccc(C[C@@H]2CNCCN2C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1C.ClCCl.[I-]>>CC(=O)c1ccc(C(=O)N2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](Cc3ccc(C)c(C)c3)C2)cc1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CO.Cl.Cl.NO.O.O=C(O)CCC(=O)c1ccc(-c2ccc(Cl)cc2)cc1.O=C([O-])[O-].[Na+].[Na+]>>O=C(O)CCC(=NO)c1ccc(-c2ccc(Cl)cc2)cc1",
        "output": "212"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1c(Br)cc(C(C)(C)C)c(O)c1C(=O)O.Nc1c(Cl)cc(Cl)cc1[N+](=O)[O-]>>Cc1c(Br)cc(C(C)(C)C)c(O)c1C(=O)Nc1c(Cl)cc(Cl)cc1[N+](=O)[O-]",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCNCC1.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2c(c1)c(=O)[nH]c1nccc(Nc3ccc(NC(=O)c4ccccc4)cc3)c12>>CN1CCN(C(=O)c2ccc3c(c2)c(=O)[nH]c2nccc(Nc4ccc(NC(=O)c5ccccc5)cc4)c23)CC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.CCCCc1ccc(C=O)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.Cl.[BH4-].[Na+]>>CCCCc1ccc(CO)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "476"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CN1CCN(CC(=O)N2CCCc3ccc([N+](=O)[O-])cc32)CC1.Cl.[Na+].[OH-]>>CN1CCN(CCN2CCCc3ccc([N+](=O)[O-])cc32)CC1",
        "output": "112"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.Cn1c(C2CC2)nc2ccc(-n3ccc(CO)cc3=O)cc21.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.Oc1ccc(Cl)cc1>>Cn1c(C2CC2)nc2ccc(-n3ccc(COc4ccc(Cl)cc4)cc3=O)cc21",
        "output": "347"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.N#Cc1ccccc1N.O=C1CCC(=O)N1I>>N#Cc1cc(I)ccc1N",
        "output": "834"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.CSc1sc(-c2ccn(COCC[Si](C)(C)C)n2)c2c1C(=O)N(C(C)C)CC2.Cl>>CSc1sc(-c2cc[nH]n2)c2c1C(=O)N(C(C)C)CC2",
        "output": "813"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.NCC1CC1.O=C(Cl)c1ccc(Br)cc1>>O=C(NCC1CC1)c1ccc(Br)cc1",
        "output": "271"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)Cl.COc1cccc([C@H]2O[C@H](Cc3ncc(CCC(=O)O)s3)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC.O.c1ccncc1>>COc1cccc([C@H]2O[C@H](Cc3ncc(CCC(=O)O)s3)C(=O)N(CC(C)(C)COC(C)=O)c3ccc(Cl)cc32)c1OC",
        "output": "126"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C(=O)OC(C)(C)C)C1CN(c2nc3ncc(I)cc3n3cnnc23)C1.ClCCl.O=C(O)C(F)(F)F>>CNC1CN(c2nc3ncc(I)cc3n3cnnc23)C1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)c1ccc(C(C)OC(C)C)cc1.Cl.O.[Li+].[OH-]>>CC(C)OC(C)c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1cc(CO)ccc1Br.ClCCl.O=[Mn]=O>>Cc1cc(C=O)ccc1Br",
        "output": "179"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=[N+]([O-])c1cc(OC(F)(F)F)ccc1O.[Pd]>>Nc1cc(OC(F)(F)F)ccc1O",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)COCCCC(=O)O.CN(C)C=O.Cc1ccccc1.O=C(Cl)C(=O)Cl>>CCOC(=O)COCCCC(=O)Cl",
        "output": "56"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCOC(C)=O.CC[C@@H]1c2nncn2-c2cnc(Cl)nc2N1C1CCCC1.CNC(=O)c1ccc(N)c(C(F)(F)F)c1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2]>>CC[C@@H]1c2nncn2-c2cnc(Nc3ccc(C(=O)NC)cc3C(F)(F)F)nc2N1C1CCCC1",
        "output": "941"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCCCCCOc1ccccc1.CN1CCCC1=O.O=C([O-])[O-].O=[N+]([O-])c1cccc(O)c1.[I-].[K+].[K+].[K+]>>O=[N+]([O-])c1cccc(OCCCCCOc2ccccc2)c1",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.O=C1CCCOc2ccc(Br)cc21>>O=C1c2cc(Br)ccc2OCCC1Br",
        "output": "82"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCCCCCC(=O)O.CCN(C(C)C)C(C)C.CCOCC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CNOC.F[P-](F)(F)(F)(F)F.O>>CON(C)C(=O)CCCCCNC(=O)OC(C)(C)C",
        "output": "54"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=C1c2cc([N+](=O)[O-])ccc2C2(CCCC2)C(=O)N1CC1CC1.[H][H].[Pd]>>Nc1ccc2c(c1)C(=O)N(CC1CC1)C(=O)C21CCCC1",
        "output": "489"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=c1n(CCCCl)nc2ccccn12.c1ccc2c(C3CCNCC3)c[nH]c2c1>>O=c1n(CCCN2CCC(c3c[nH]c4ccccc34)CC2)nc2ccccn12",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN=C=NCCCN(C)C.Cl.ClC(Cl)Cl.O=C(O)c1cccc(Cl)c1F.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCN(C(=O)c2cccc(Cl)c2F)CC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.Cc1ccc(CC(C)(CO)c2cccnc2)cc1.O=[Ru](=O)(=O)[O-]>>Cc1ccc(CC(C)(C=O)c2cccnc2)cc1",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)c1ccc2c(c1)OC1(O)c3cccc([N+](=O)[O-])c3C(=O)C21NC(=O)c1cnc2ccccc2c1.CCO.Cl.O.[Fe]>>CC(C)c1ccc2c(c1)OC1(O)c3cccc(N)c3C(=O)C21NC(=O)c1cnc2ccccc2c1",
        "output": "706"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCNC.CCO.OC(CBr)C(c1ccccc1)c1ccccc1>>CCN(C)CC(O)C(c1ccccc1)c1ccccc1",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)c1cc(OC)c(C)c(OC)c1Oc1cc(OC)cc(C)c1C(=O)O.COC(Cl)Cl.Cl.ClCCl.Cl[Ti](Cl)(Cl)Cl>>COC(=O)c1cc(OC)c(C)c(OC)c1Oc1c(C=O)c(OC)cc(C)c1C(=O)O",
        "output": "591"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(O)c1ccncc1F.Cc1ccccc1.[Mn+4].[O-2].[O-2]>>CCC(=O)c1ccncc1F",
        "output": "32"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1cc(Br)ccc1C(=O)O.OCCc1ccccn1>>Cc1cc(Br)ccc1C(=O)OCCc1ccccn1",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.NN.O=C(NCc1ccccc1)c1ccc(Cl)nc1>>NNc1ccc(C(=O)NCc2ccccc2)cn1",
        "output": "417"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1ccc(C(F)(F)F)cc1.O=C(O)c1cc(Br)ccn1>>O=C(Nc1ccc(C(F)(F)F)cc1)c1cc(Br)ccn1",
        "output": "548"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)Cn1c(CNC(=O)OC(C)(C)C)c(-c2ccccc2)c2cc(CN3C(=O)c4ccccc4C3=O)ccc2c1=O.CCO.NN.O>>CC(C)Cn1c(CNC(=O)OC(C)(C)C)c(-c2ccccc2)c2cc(CN)ccc2c1=O",
        "output": "418"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)c1cc(C2CC2)cnc1Nc1cccc2c1ccn2CC1CCC1.CO.[Na+].[OH-]>>O=C(O)c1cc(C2CC2)cnc1Nc1cccc2c1ccn2CC1CCC1",
        "output": "569"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOCCN.Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)O)ccc21.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>CCOCCNC(=O)c1ccc2c(c1)nc(Nc1nc3ccc(OC(F)(F)F)cc3s1)n2C",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CI.CN(C)C=O.O.O=C([O-])[O-].O=Cc1cc(Br)c(-c2ccc(F)cc2)c(F)c1O.[K+].[K+]>>COc1c(C=O)cc(Br)c(-c2ccc(F)cc2)c1F",
        "output": "62"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CNC1(NC)C=CN=CC1.COc1ccc2nc(N)sc2c1.O=C(Cl)c1cccc(Cl)c1>>COc1ccc2nc(NC(=O)c3cccc(Cl)c3)sc2c1",
        "output": "673"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CN(C)c1ccccn1.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.ClCCl.O.O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCO[C@](CCO)(c2ccc(Cl)c(Cl)c2)C1>>Cc1ccc(S(=O)(=O)OCC[C@@]2(c3ccc(Cl)c(Cl)c3)CN(C(=O)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CCO2)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)C1=Cc2cc(-c3ccc4c(c3)OCO4)ccc2S(=O)(=O)CC1.COCCOC.Cl>>O=C(O)C1=Cc2cc(-c3ccc4c(c3)OCO4)ccc2S(=O)(=O)CC1",
        "output": "58"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)C(C)C(=O)Nc1cccc(F)c1Cl>>CC(C(=O)O)C(=O)Nc1cccc(F)c1Cl",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COC(=O)CNC(=O)c1cccc2ccccc12.NN.O.O>>NNC(=O)CNC(=O)c1cccc2ccccc12",
        "output": "130"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.CN[C@@H]1CCN(C(=O)OC(C)(C)C)C1.CS(=O)(=O)OCCc1c[nH]c2ccc(-n3cnnc3)cc12.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CN(CCc1c[nH]c2ccc(-n3cnnc3)cc12)[C@@H]1CCN(C(=O)OC(C)(C)C)C1",
        "output": "496"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)S(=O)(=O)Nc1cc([C@@H](O)CN)ccc1O.O=C1CCN(c2ccc(CC3SC(=O)NC3=O)cc2)CC1>>CC(C)S(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(CC4SC(=O)NC4=O)cc3)CC2)ccc1O",
        "output": "236"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CN(C)C=O.O=C(c1ccc(F)cc1)C1CCNCC1.O=c1c2ccccc2n(-c2ccccc2)c(=O)n1CCCl>>O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)c3ccccc3n(-c3ccccc3)c2=O)CC1",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)Nc1nc(Cl)cc2cc[nH]c(=O)c12.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].OCC(O)CCl.[Cs+].[Cs+]>>CC(C)(C)Nc1nc(Cl)cc2ccn(CC(O)CO)c(=O)c12",
        "output": "42"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCN(CCN(C)Cc1cccnc1)Cc1ccccc1-3.[Na+].[OH-]>>CN(CCN1CCn2c(c(C3CCCCC3)c3ccc(C(=O)O)cc32)-c2ccccc2C1)Cc1cccnc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C(O)COc1nc2ccccc2s1.c1ccc2c(c1)CCCN2>>O=C(COc1nc2ccccc2s1)N1CCCc2ccccc21",
        "output": "315"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)CCC(Cc2ccc(Cl)cc2)C1(O)CO.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC1(C)CCC(Cc2ccc(Cl)cc2)C1(O)COS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CC(=O)NCc1ccc(CN2CCN(c3ccc(N)cc3)CC2)cc1.CCOC(C)=O.O.O.O=C([O-])[O-].[Cl-].[K+].[K+].[Na+]>>CC(=O)NCc1ccc(CN2CCN(c3ccc(NC(C)=O)cc3)CC2)cc1",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1noc(-c2ccc(Br)cc2)c1NC(C)CCc1ccc(Cl)cc1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4NC(C)CCc4ccc(Cl)cc4)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(N)Cc1ccccc1.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1nnc(-c2ccc(C)c(-c3ccc(C(=O)O)cc3)c2)o1.Cl.On1nnc2ccccc21>>Cc1nnc(-c2ccc(C)c(-c3ccc(C(=O)NC(C)Cc4ccccc4)cc3)c2)o1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(=O)Oc1ccc(C=O)cc1.CC(C)(C)OC(=O)CCN.Cl.ClCCl.[Na+]>>CC(=O)Oc1ccc(CNCCC(=O)OC(C)(C)C)cc1",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.Cc1ccccc1.O=C(O)Cc1ccccc1C(=O)O>>O=C1Cc2ccccc2C(=O)O1",
        "output": "436"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCN.Cc1ccc(-c2nc(C(=O)O)n(C)c2-c2ccc(C)cc2)cc1>>CCCNC(=O)c1nc(-c2ccc(C)cc2)c(-c2ccc(C)cc2)n1C",
        "output": "951"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Nc1ccc(C(F)(F)F)cc1C(=O)O.O=S(=O)(O)O>>CCOC(=O)c1cc(C(F)(F)F)ccc1N",
        "output": "33"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Nc1cccc(S(N)(=O)=O)c1.O=C(O)CC1CCc2cc(Br)cc3[nH]c(=O)c(=O)n1c23>>NS(=O)(=O)c1cccc(NC(=O)CC2CCc3cc(Br)cc4[nH]c(=O)c(=O)n2c34)c1",
        "output": "365"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNCC1.O=C(O)CCCCC1SCC(C(=O)Nc2nc(-c3ccc(C(=O)NC4CC4)cc3)cs2)N1C(=O)OCc1ccccc1>>O=C(NC1CC1)c1ccc(-c2csc(NC(=O)C3CSC(CCCCC(=O)N4CCCCC4)N3C(=O)OCc3ccccc3)n2)cc1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCNCCC.Cl.ClCCCOc1ccc(/C=C/c2nc3ccccc3o2)cc1>>CCCN(CCC)CCCOc1ccc(/C=C/c2nc3ccccc3o2)cc1",
        "output": "138"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(C)=O.Cc1cc(O)c(C)cc1N.Clc1ccc(Cl)nn1.[H-].[Na+]>>Cc1cc(Oc2ccc(Cl)nn2)c(C)cc1N",
        "output": "603"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.NS(=O)(=O)N1CCC1.O=C(O)c1cc(C2CC2)c(OC2CCC3(CC2)CC3)cc1F.O=C1CCC(Oc2cc(F)c(C(=O)O)cc2Cl)CC1>>O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OC2CCC3(CC2)CC3)cc1F",
        "output": "886"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1ccc(N)nc1.COc1cccc2c1CC1=C(O2)C(=O)N([C@@H](CC2CCCCC2)C(=O)O)C1.ClCCl.O.On1nnc2ccccc21>>COC(=O)c1ccc(NC(=O)[C@H](CC2CCCCC2)N2CC3=C(Oc4cccc(OC)c4C3)C2=O)nc1",
        "output": "368"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.O=C1Nc2cccnc2N2CCN(C(=O)OCc3ccccc3)CC12.[Pd]>>O=C1Nc2cccnc2N2CCNCC12",
        "output": "428"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCc1csc(-c2cc(F)ccc2[N+](=O)[O-])n1.[OH-].[OH-].[Pd+2]>>CCc1csc(-c2cc(F)ccc2N)n1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOc1ccc(C[C@@H](C(=O)O)N2C(=O)c3ccccc3C2=O)cc1.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCOc1ccc2c(c1)C(=O)[C@@H](N1C(=O)c3ccccc3C1=O)C2",
        "output": "274"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)Br.CN(C)C=O.COc1ccc(CO)cc1O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(CO)cc1OC(C)C",
        "output": "153"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3cnc(OCCO)cc32)CC1.ClCCl>>CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3cnc(OCC=O)cc32)CC1",
        "output": "142"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Fc1ccc(Cl)c(Br)c1.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>O=[N+]([O-])c1cc(Cl)c(Br)cc1F",
        "output": "103"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCCCCCCBr.Cc1cc(C)[nH]n1.[H][H].[Na]>>CCCCCCCCn1nc(C)cc1C",
        "output": "577"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O=[Mn]=O.OCc1cncc(Br)c1>>O=Cc1cncc(Br)c1",
        "output": "520"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCNCCCC.CCN(C(C)C)C(C)C.CN(C)C=O.COc1ccc2oc(C(=O)c3ccccc3)c(CC(=O)O)c2c1.ClCCCl.On1nnc2ccccc21>>CCCCN(CCCC)C(=O)Cc1c(C(=O)c2ccccc2)oc2ccc(OC)cc12",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#Cc1cccnc1.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Nc1c(F)cc(Cl)cc1I.[Cu]I>>Nc1c(F)cc(Cl)cc1C#Cc1cccnc1",
        "output": "664"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CN(C)C=O.CN(C)CCCl.Cl.Clc1cc2c(-c3cn[nH]c3)cccc2cn1.O=C([O-])[O-].[K+].[K+]>>CN(C)CCn1cc(-c2cccc3cnc(Cl)cc23)cn1",
        "output": "604"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=CCCC(C)=CCCC(C)=CCCC(=O)Cl.CCOCC.CN(C)CCN.[Na+].[OH-]>>CC(C)=CCCC(C)=CCCC(C)=CCCC(=O)NCCN(C)C",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(CC(=O)Cl)cc1OC.O=C(NCC(F)(F)F)C1(CCCCN2CCNCC2)c2ccccc2-c2ccccc21>>COc1ccc(CC(=O)N2CCN(CCCCC3(C(=O)NCC(F)(F)F)c4ccccc4-c4ccccc43)CC2)cc1OC",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OCCN(C)C(=O)C1(CCC(C)C)C(=O)C(C2=NS(=O)(=O)c3cc(NS(C)(=O)=O)ccc3N2)C(=O)c2ccccc21.CC(=O)OC[C@H]1CCCN1C(=O)[C@]1(CCC(C)C)C(=O)C(C2=NS(=O)(=O)c3cc(NS(C)(=O)=O)ccc3N2)=C(O)c2ccccc21>>CC(C)CCC1(C(=O)N(C)CCO)C(=O)C(C2=NS(=O)(=O)c3cc(NS(C)(=O)=O)ccc3N2)C(=O)c2ccccc21",
        "output": "225"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCn1nc2c(N)nc3ccccc3c2c1NCCC1CCNCC1.CCN(CC)CC.CS(=O)(=O)Cl.Cl.Cl.ClCCl>>CCCn1nc2c(N)nc3ccccc3c2c1NCCC1CCN(S(C)(=O)=O)CC1",
        "output": "584"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCS(=O)(=O)N1CCN(Cc2cnc(NC(=O)N(C3CCCCC3)C3CC[NH2+]CC3)s2)CC1.O=C(Cl)C1CCCC1.[Cl-]>>CCS(=O)(=O)N1CCN(Cc2cnc(NC(=O)N(C3CCCCC3)C3CCN(C(=O)C4CCCC4)CC3)s2)CC1",
        "output": "125"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(COc2ccc([N+](=O)[O-])cc2)cc1.[Ni]>>COc1ccc(COc2ccc(N)cc2)cc1",
        "output": "202"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C([O-])[O-].OC1CCCNC1.[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCCC(O)C1",
        "output": "694"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1Oc2ccc(CO)cc2NC1=O.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC1Oc2ccc(CCl)cc2NC1=O",
        "output": "713"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC)C1CCNCC1.CCOC(=O)Cn1ccnc1CCC(=O)O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClC(Cl)Cl.F[P-](F)(F)(F)(F)F>>CCOC(=O)Cn1ccnc1CCC(=O)N1CCC(N(CC)CC)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)OC(CO)Cc1ccc(Cl)cc1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)OC(COS(C)(=O)=O)Cc1ccc(Cl)cc1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cc1nc2c(Cl)nc3ccccc3c2n1Cc1cc(-c2ccc(F)cc2)no1.N>>Cc1nc2c(N)nc3ccccc3c2n1Cc1cc(-c2ccc(F)cc2)no1",
        "output": "682"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)C(Cc1ccc(OCCc2ccc(OS(C)(=O)=O)cc2)cc1)OCC.O.O.[Li+].[OH-]>>CCOC(Cc1ccc(OCCc2ccc(OS(C)(=O)=O)cc2)cc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)n1cc(C=O)c2cc(Br)ccc21.CN(C)C=O.Cl[Pd]Cl.O=C([O-])[O-].OB(O)c1ccc(F)c(F)c1F.[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)n1cc(C=O)c2cc(-c3ccc(F)c(F)c3F)ccc21",
        "output": "837"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCOC(=O)CCCc1ccc2cnn(-c3ccc(F)cc3)c2c1.Cl.O.[Li+].[OH-]>>O=C(O)CCCc1ccc2cnn(-c3ccc(F)cc3)c2c1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C/C(=C\\c1ccc(C(=O)O)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C.OCCO>>C/C(=C\\c1ccc(C(=O)OCCO)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C",
        "output": "47"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.COC(=O)c1cc(OC)c2oc(NCc3cc(Cl)ccn3)nc2c1.[Na+].[OH-]>>COc1cc(C(=O)O)cc2nc(NCc3cc(Cl)ccn3)oc12",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC12COCCN1c1nc(Cl)ncc1N(C1CC1)C2=O.CNC(=O)Nc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.Cl[Pd]Cl.O.O=C([O-])O.[Fe+2].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CNC(=O)Nc1ccc(-c2ncc3c(n2)N2CCOCC2(C)C(=O)N3C2CC2)cc1",
        "output": "974"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CNC.COc1cc(F)ccc1-c1nnc(-c2c(-c3ccccc3)noc2C)o1.Cl>>COc1cc(N(C)C)ccc1-c1nnc(-c2c(-c3ccccc3)noc2C)o1",
        "output": "26"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1c[nH]c2c(C(=O)O)cc(Br)cc12.CN(C)C=O.CN1CCOCC1.Cc1cc(C)c(CN)c(=O)[nH]1.ClCCCl.On1nnc2cccnc21>>Cc1cc(C)c(CNC(=O)c2cc(Br)cc3c(C(C)C)c[nH]c23)c(=O)[nH]1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(NC(=O)CCCCCCC(=O)[O-])cc1.CO.[Na+].[OH-]>>CC(C)(C)OC(=O)NCc1ccc(NC(=O)CCCCCCC(=O)O)cc1",
        "output": "151"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCCCC1CCNCC1.CCOC(C)=O.C[C@H](CI)Cn1c(=O)ccc2ccccc21.O>>CCCCC1CCN(C[C@@H](C)Cn2c(=O)ccc3ccccc32)CC1",
        "output": "184"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.Oc1cccc2c1cnn2-c1ccc(OCc2ccccc2)c(F)c1.[Pd]>>Oc1ccc(-n2ncc3c(O)cccc32)cc1F",
        "output": "698"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=O.CO.COc1c(N2CCNCC2)cc(S(=O)(=O)n2cc(C(F)F)c3cc(Cl)ccc32)c2ccccc12.[BH3-]C#N.[Na+]>>COc1c(N2CCN(C)CC2)cc(S(=O)(=O)n2cc(C(F)F)c3cc(Cl)ccc32)c2ccccc12",
        "output": "217"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COC(=O)C(C)c1cncnc1OC.O.O.[Li+].[OH-]>>COc1ncncc1C(C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.Cc1cc(C)c2c(c1)OCC2c1ccc(C(C)C)cc1.O=C1CCC(=O)N1Br>>Cc1cc2c(c(C)c1Br)C(c1ccc(C(C)C)cc1)CO2",
        "output": "4"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOc1cc(OC(C)C)c(F)c(C(Nc2ccc(-c3noc(C)n3)cc2)c2nc(-c3ccccc3C(C)=O)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1.CO.[BH4-].[Na+]>>CCOc1cc(OC(C)C)c(F)c(C(Nc2ccc(-c3noc(C)n3)cc2)c2nc(-c3ccccc3C(C)O)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1",
        "output": "24"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Nc1ccc(F)cc1CCN1CCN(c2nsc3ccccc23)CC1.O=C=Nc1ccccc1Cl>>O=C(Nc1ccccc1Cl)Nc1ccc(F)cc1CCN1CCN(c2nsc3ccccc23)CC1",
        "output": "473"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C(=O)O)c1ccc(C#N)cc1.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.NCc1ccc(C(F)(F)F)nc1N1CCCC1.On1nnc2ccccc21>>CC(C(=O)NCc1ccc(C(F)(F)F)nc1N1CCCC1)c1ccc(C#N)cc1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "NN.O.O=C1c2ccccc2C(=O)N1CCOCCN1CCN(C(c2ccccc2)c2ccccc2)CC1>>NCCOCCN1CCN(C(c2ccccc2)c2ccccc2)CC1",
        "output": "242"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)[O-].CCO.COc1ccc(O)c(N)c1.Cl.O.O=[N+]([O-])c1ccc(Cl)c([N+](=O)[O-])c1.[Na+]>>COc1ccc(O)c(Nc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])c1",
        "output": "510"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.COC(=O)c1ccc(OCc2c(-c3ccc(F)c(F)c3)noc2CO)nc1.C[Al](C)C.NCC1CC1>>O=C(NCC1CC1)c1ccc(OCc2c(-c3ccc(F)c(F)c3)noc2CO)nc1",
        "output": "862"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1=CCCCC1.CC(Cc1cccc(C(=O)OCc2ccccc2)c1O)C[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C.CCO.[Pd]>>CC(Cc1cccc(C(=O)O)c1O)C[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C",
        "output": "290"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOP(=O)(Cc1ccccc1)OCC.O>>O=P(O)(O)Cc1ccccc1",
        "output": "535"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)CC1CN=C(c2cc3cc(Oc4ccc(COC)nc4)cc(OC(C)C)c3[nH]2)S1.Cl.O.[Na+].[OH-]>>COCc1ccc(Oc2cc(OC(C)C)c3[nH]c(C4=NCC(CC(=O)O)S4)cc3c2)cn1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1cc(F)ccc1COc1cccc(F)c1.[Na+].[OH-]>>O=C(O)c1cc(F)ccc1COc1cccc(F)c1",
        "output": "5"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)c1nccc(C2CN(C(=O)OC(C)(C)C)CCO2)n1.ClCCl.O=C(O)C(F)(F)F>>CC(C)c1nccc(C2CNCCO2)n1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNC1.O=C(Nc1ccc(Cl)nc1)c1cc2ccc(C(F)(F)F)nc2n1Cc1cccc(F)c1>>O=C(Nc1ccc(N2CCCC2)nc1)c1cc2ccc(C(F)(F)F)nc2n1Cc1cccc(F)c1",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCn1c(=O)c2cc([N+](=O)[O-])ccc2n(CCC#N)c1=O.Cl[Sn]Cl>>CCn1c(=O)c2cc(N)ccc2n(CCC#N)c1=O",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCN2C(=O)N(CCO)CC2C1.ClCCl.O=C(O)C(F)(F)F>>O=C1N(CCO)CC2CNCCN12",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)COc1cccc2sc(C(=O)O)cc12.Cl.Cl.Cl.NC1CCN(CCN2CCCCCC2)CC1>>CC(C)COc1cccc2sc(C(=O)NC3CCN(CCN4CCCCCC4)CC3)cc12",
        "output": "736"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.Nc1ccc(Br)cc1N.O=P(Cl)(Cl)Cl>>Cc1nc2cc(Br)ccc2[nH]1",
        "output": "512"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CC(C)(Oc1ccc(CCC(O)c2cc(-c3ccc(C(F)(F)F)cc3)cs2)c(Cl)c1Cl)C(=O)O.[H-].[Na+]>>CC(C)(Oc1ccc(CCC(OCc2ccccc2)c2cc(-c3ccc(C(F)(F)F)cc3)cs2)c(Cl)c1Cl)C(=O)O",
        "output": "464"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=COCCON.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cc1cnnc2c(F)c(Nc3ccc(Cl)cc3Cl)c(C(=O)O)cc12.O.On1nnc2ccccc21>>C=COCCONC(=O)c1cc2c(C)cnnc2c(F)c1Nc1ccc(Cl)cc1Cl",
        "output": "741"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOc1ccc(C(=O)NCCN)cc1.CN(C)C=O.Cl.Cl.O.O=C(O)c1c[nH]nc1C(F)(F)F.On1nnc2ccccc21>>CCOc1ccc(C(=O)NCCNC(=O)c2c[nH]nc2C(F)(F)F)cc1",
        "output": "621"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(C)=O.Nc1cccc(Cl)c1.O=c1cc(CBr)c2cccc(F)c2[nH]1>>O=c1cc(CNc2cccc(Cl)c2)c2cccc(F)c2[nH]1",
        "output": "272"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCCC(Cc2ccc(N3CC(=O)NS3(=O)=O)c(O)c2)C1.CCOCC.Cl>>O=C1CN(c2ccc(CC3CCCNC3)cc2O)S(=O)(=O)N1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O=C(O)Cc1ccccc1Cl.O=C([O-])[O-].O=S(=O)(O)O.[Na+].[Na+]>>CCOC(=O)Cc1ccccc1Cl",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC1(O)CC1[Si](C)(C)C.CCN(CC)CC.CCS(=O)(=O)Cl.ClCCl.O=C([O-])O.[Na+]>>CCC1(OS(=O)(=O)CC)CC1[Si](C)(C)C",
        "output": "0"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.O.O=C1CN2CCC(CC2)N1>>C1CN2CCC(CC2)N1",
        "output": "490"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC(C)=O.O=C([O-])[O-].O=C(c1ccc(OCCCCl)cc1)C1CC1.OC1CCNC1.[I-].[K+].[K+].[K+]>>O=C(c1ccc(OCCCN2CCC(O)C2)cc1)C1CC1",
        "output": "138"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=Cc1c(Cl)ccc(N)c1Cl.CCOC(C)=O.[Pd]>>CCc1c(Cl)ccc(N)c1Cl",
        "output": "555"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.C[O-].Clc1ccc(Cl)nn1.O.[Na+]>>COc1ccc(Cl)nn1",
        "output": "407"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCC.CO.COC(=O)C(OC(C)(C)C)c1c(C(C)C)nc2c(c1-c1ccc(F)cc1)CN(C(=O)C(F)(F)F)CC2(C)C.O=C([O-])[O-].[K+].[K+]>>COC(=O)C(OC(C)(C)C)c1c(C(C)C)nc2c(c1-c1ccc(F)cc1)CNCC2(C)C",
        "output": "703"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.ClCCl.NCc1cccc(-c2cncc(OC[C@@H]3CCN3C(=O)OCc3ccccc3)c2)c1>>CC(=O)NCc1cccc(-c2cncc(OC[C@@H]3CCN3C(=O)OCc3ccccc3)c2)c1",
        "output": "515"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN.CSC(=C[N+](=O)[O-])NCCSCc1nnc(N)s1>>CCNC(=C[N+](=O)[O-])NCCSCc1nnc(N)s1",
        "output": "270"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.CC(C)CC(C#N)NC(=O)C1CCCCC1NC(=O)c1cc2ccc(Cl)cc2n1CCCCl.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CC(C)CC(C#N)NC(=O)C1CCCCC1NC(=O)c1cc2ccc(Cl)cc2n1CCCN1CCOCC1",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1c(N2CCNCC2)nc2cc(F)cc(F)c2c1Nc1cncc(N2CCOCC2)c1.O=C1CCOCC1>>Cc1c(N2CCN(C3CCOCC3)CC2)nc2cc(F)cc(F)c2c1Nc1cncc(N2CCOCC2)c1",
        "output": "187"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COCCOC.Cl[Pd]Cl.Nc1ncnc2c1C(=O)N(c1ccc(OS(=O)(=O)C(F)(F)F)c(F)c1)CCO2.O=P([O-])([O-])[O-].OB(O)c1ccccc1Cl.[Fe+2].[K+].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Nc1ncnc2c1C(=O)N(c1ccc(-c3ccccc3Cl)c(F)c1)CCO2",
        "output": "825"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCc1c(C)c2c(c(O)c1C/C=C(\\C)CCC(=O)O)C(=O)OC2.CO.Cc1ccc(S(=O)(=O)O)cc1>>CCc1c(C)c2c(c(O)c1C/C=C(\\C)CCC(=O)OC)C(=O)OC2",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CCN(c2cc(N)c(CO)cn2)CC1.ClCCl.O=[Mn]=O>>CN1CCN(c2cc(N)c(C=O)cn2)CC1",
        "output": "520"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C(=O)OC(C)(C)C)[C@@H]1CC[C@@H](Nc2c(C(=O)C3CC3)cnc3ccc(-c4cc(Cl)c(O)c(Cl)c4)cc23)CC1.O=C(O)C(F)(F)F>>CN[C@@H]1CC[C@@H](Nc2c(C(=O)C3CC3)cnc3ccc(-c4cc(Cl)c(O)c(Cl)c4)cc23)CC1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)CCC1(C)Cn2cc([N+](=O)[O-])nc2O1.ClCCl.O=C(O)C(F)(F)F>>CC1(CCC(=O)O)Cn2cc([N+](=O)[O-])nc2O1",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.Cl.O.O=C(O)CC1(c2ccc(Cl)cc2)C2CC3CC(C2)CC1C3.On1nnc2ccccc21.[Cl-].[NH4+]>>NC(=O)CC1(c2ccc(Cl)cc2)C2CC3CC(C2)CC1C3",
        "output": "313"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN.Cc1cc(F)ccc1-n1ccc2c(Cl)nc3c(OCC(F)(F)F)cccc3c21>>CNc1nc2c(OCC(F)(F)F)cccc2c2c1ccn2-c1ccc(F)cc1C",
        "output": "110"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCN(C2CCNCC2)C1.CCN(C(C)C)C(C)C.CN1CCCC1=O.COc1cc(F)ccc1[N+](=O)[O-]>>COc1cc(N2CCC(N3CCCC3)CC2)ccc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)OCc1ccc(OC)cc1.O.[BH4-].[I-].[Li+].[Na+]>>COc1ccc(COC(=O)N2C[C@H](O[Si](C)(C)C(C)(C)C)C[C@H]2CO)cc1",
        "output": "430"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.NC(=O)c1cc(-c2cccc(F)c2)cc2c(C3CCN(S(=O)(=O)CCCCl)CC3)n[nH]c12.NC1CCCC1.O=C([O-])[O-].[K+].[K+]>>NC(=O)c1cc(-c2cccc(F)c2)cc2c(C3CCN(S(=O)(=O)CCCNC4CCCC4)CC3)n[nH]c12",
        "output": "279"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.NCCO.O.O=[N+]([O-])c1cc(S(=O)(=O)Cl)sc1Cl.[Mg+2].[O-2]>>O=[N+]([O-])c1cc(S(=O)(=O)NCCO)sc1Cl",
        "output": "600"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "N#Cc1cccc(C(=O)O)c1.Nc1cccc(-c2nnn[nH]2)c1>>N#Cc1cccc(C(=O)Nc2cccc(-c3nnn[nH]3)c2)c1",
        "output": "50"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC12COc3cccc(O)c3C1C2.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)nc1.[K+].[K+]>>CC12COc3cccc(Oc4ccc([N+](=O)[O-])cn4)c3C1C2",
        "output": "516"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCC.COc1ccccc1.O=C(Cl)c1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(C(=O)c2ccccc2)cc1",
        "output": "61"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.COc1cc(OC)c(Cl)c(-c2cc3cnc(Nc4ccccc4[N+](=O)[O-])c(C)c3n(C)c2=O)c1Cl>>COc1cc(OC)c(Cl)c(-c2cc3cnc(Nc4ccccc4N)c(C)c3n(C)c2=O)c1Cl",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.[OH-].[OH-].[Pd+2].c1ccc(CNC2CCC3(CC2)OCCO3)cc1>>NC1CCC2(CC1)OCCO2",
        "output": "561"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CI.CN(C)C=O.O.O=C([O-])[O-].O=Cc1cc(F)cc(Cl)c1O.[K+].[K+]>>COc1c(Cl)cc(F)cc1C=O",
        "output": "62"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCCO.Cl.N#Cc1cnc2c(sc3ccc([N+](=O)[O-])cc32)c1Cl.Nc1cccc(Br)c1.c1ccncc1>>N#Cc1cnc2c(sc3ccc([N+](=O)[O-])cc32)c1Nc1cccc(Br)c1",
        "output": "927"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCC/C=C/C(=O)O.CN(C)CCCNCCCN(C)C>>CCCCCCC/C=C/C(=O)N(CCCN(C)C)CCCN(C)C",
        "output": "870"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.ClCCCBr.[K+].[OH-].c1ccc2[nH]ccc2c1>>ClCCCn1ccc2ccccc21",
        "output": "470"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)n1nc(N)nc1-c1cn2c(n1)-c1cc(Br)ccc1OCC2.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccc(Cl)cc1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)n1nc(N)nc1-c1cn2c(n1)-c1cc(-c3ccc(Cl)cc3)ccc1OCC2",
        "output": "837"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C[C@H](N)C(=O)N1CC[C@H]2OC[C@H](O)[C@H]21.CCCN1CCN(c2ccc(C(=O)O)cc2)CC1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.Cl.F[P-](F)(F)(F)(F)F.O.On1nnc2ccccc21>>CCCN1CCN(c2ccc(C(=O)N[C@@H](CC(C)C)C(=O)N3CC[C@H]4OC[C@H](O)[C@H]43)cc2)CC1",
        "output": "718"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COCCC(C(=O)O)n1cc(Cl)c(-c2cc(Cl)ccc2C#N)cc1=O.Nc1ccn2nccc2c1>>COCCC(C(=O)Nc1ccn2nccc2c1)n1cc(Cl)c(-c2cc(Cl)ccc2C#N)cc1=O",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)c1ccc(C(=O)O)cc1.CC(C)(C)OC(=O)c1cc2cc(N)ccc2[nH]1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F>>CC(=O)c1ccc(C(=O)Nc2ccc3[nH]c(C(=O)OC(C)(C)C)cc3c2)cc1",
        "output": "50"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCc1ccccc1.CC#N.CCOC(=O)C(C)(O)CNC1CCCCC1.CCOC(C)=O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C(C)(O)CN(Cc1ccccc1)C1CCCCC1",
        "output": "248"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(C)Oc1ccc(-c2cnc(-c3cccc4c3CCC4O[Si](C)(C)C(C)(C)C)s2)cc1C#N.Cl>>CC(C)Oc1ccc(-c2cnc(-c3cccc4c3CCC4O)s2)cc1C#N",
        "output": "708"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCc1cccc(Br)c1.CS(C)=O.Nc1ncccc1-c1ccc(O)cc1.O=C(O)c1ccccn1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>CCc1cccc(Oc2ccc(-c3cccnc3N)cc2)c1",
        "output": "238"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)c1ccc(C(=O)CCC(=O)O)cc1.Cl.NN.O.O.[K+].[OH-]>>CC(C)c1ccc(CCCC(=O)O)cc1",
        "output": "92"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.COc1cc(O)ccc1-c1ccc2c(c1COc1cc(F)ccc1C)C(C)=CC(C)(C)N2.CS(=O)(=O)Cl.ClCCl>>COc1cc(OS(C)(=O)=O)ccc1-c1ccc2c(c1COc1cc(F)ccc1C)C(C)=CC(C)(C)N2",
        "output": "149"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=Cc1ccc(OCc2ccccc2)cc1O.[BH4-].[Na+]>>OCc1ccc(OCc2ccccc2)cc1O",
        "output": "356"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.O=C(O)CCCCCBr.Oc1ccc(S)cc1>>O=C(O)CCCCCSc1ccc(O)cc1",
        "output": "124"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CCc1cc2cc([N+](=O)[O-])cnc2n1S(=O)(=O)c1ccccc1.CO.O.O=C([O-])[O-].[K+].[K+]>>CCc1cc2cc([N+](=O)[O-])cnc2[nH]1",
        "output": "831"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C1CCC(Oc2ncnc3sc4c(c23)[C@@H](CO)CC4)CC1>>CS(=O)(=O)OC[C@H]1CCc2sc3ncnc(OC4CCC(=O)CC4)c3c21",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCN(CC)CC.Nc1cccc2ccc(O)cc12.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>Nc1cccc2ccc(OS(=O)(=O)C(F)(F)F)cc12",
        "output": "843"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)[C@H](C=C(Cl)C(F)(F)F)[C@@H]1C(=O)Cl.NCc1cccc2c1CCCc1ccccc1-2.O.c1ccccc1.c1ccncc1>>CC1(C)[C@H](C=C(Cl)C(F)(F)F)[C@@H]1C(=O)NCc1cccc2c1CCCc1ccccc1-2",
        "output": "206"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COCC(=O)N=S(C)(=O)c1ccc(N)cc1>>COCCN=S(C)(=O)c1ccc(N)cc1",
        "output": "112"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CO.Cc1nc(N2CCN(C(=O)OC(C)(C)C)[C@@H](C)C2)ccc1[N+](=O)[O-]>>Cc1nc(N2CCN(C(=O)OC(C)(C)C)[C@@H](C)C2)ccc1N",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CS(C)=O.Cc1ccc(C[C@@H]2CN(CCOCCO)CCN2C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1C.ClCCl.O=C(Cl)C(=O)Cl.[Cl-].[NH4+]>>Cc1ccc(C[C@@H]2CN(CCOCC=O)CCN2C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1C",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.FC(F)(F)c1ccc(Cl)nc1.O=C([O-])[O-].Oc1cc(Br)ccc1Cl.[K+].[K+]>>FC(F)(F)c1ccc(Oc2cc(Br)ccc2Cl)nc1",
        "output": "516"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CC[C@@H](CC(=O)OC(C)(C)C)C(=O)NC[C@H](O)c1ccccc1.C=CC[C@H](C)C(=O)O.CCOC(C)=O.ClCCl>>C=CC[C@H](C)C(=O)O[C@@H](CNC(=O)[C@@H](CC=C)CC(=O)OC(C)(C)C)c1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cc(OCC)c(-c2ccc(F)cc2)c(OCC)c1.CCOC(C)=O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>CCOc1cc(CO)cc(OCC)c1-c1ccc(F)cc1",
        "output": "311"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1cc(C=C(Cn2ccnc2)c2nccs2)cc(-c2ccccc2)c1.[Na+].[OH-]>>O=C(O)c1cc(C=C(Cn2ccnc2)c2nccs2)cc(-c2ccccc2)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#CCNc1cc(N)c(F)cc1[N+](=O)[O-].CC(=O)O.O.O=C1OC(=O)C2=C1CCCC2>>C#CCNc1cc(N2C(=O)C3=C(CCCC3)C2=O)c(F)cc1[N+](=O)[O-]",
        "output": "410"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCl.O=C([O-])O.O=S(Cl)Cl.OCc1ccc(Oc2ncccn2)cc1.[Na+].c1ccncc1>>ClCc1ccc(Oc2ncccn2)cc1",
        "output": "81"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1nc2n(c(=O)c1OCc1ccccc1)CCC=C2c1ccccc1.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)c1nc2n(c(=O)c1O)CCC=C2c1ccccc1",
        "output": "492"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.CC(=O)O.CO.Cc1cc(Cl)nc2c1CNCC(C1CC1)O2.[BH3-]C#N.[Na+]>>Cc1cc(Cl)nc2c1CN(C)CC(C1CC1)O2",
        "output": "217"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNC1.Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(C=O)cc3)cc12.O=C(O)C(F)(F)F>>Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(CN4CCCC4)cc3)cc12",
        "output": "567"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(CO[Si](C)(C)C(C)(C)C)Cc2nnc(C3(c4ccc(-c5ncco5)cc4)CC3)n2CCS1.CO.Cl>>CC1(CO)Cc2nnc(C3(c4ccc(-c5ncco5)cc4)CC3)n2CCS1",
        "output": "708"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=[Cr](=O)([O-])Cl.OCC12CC3CC(CC(C3)C1)C2.c1cc[nH+]cc1>>O=CC12CC3CC(CC(C3)C1)C2",
        "output": "142"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CNC(=O)Cn1nc(N)c2cc3cc(OC)ccc3nc21.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CNCCn1nc(N)c2cc3cc(OC)ccc3nc21",
        "output": "112"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cccnc1Cl.CS(C)=O.C[O-].O.[Na+]>>COc1cccnc1OC",
        "output": "433"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccccc1I.COc1ccc(S)cc1>>COc1ccc(Sc2ccccc2Br)cc1",
        "output": "565"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.NC(=O)CBr.O=C([O-])[O-].Oc1cccc(F)c1.[K+].[K+]>>NC(=O)COc1cccc(F)c1",
        "output": "778"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1ccc(Oc2ccnc3ccsc23)c(F)c1.O=C(Cc1ccccc1)NC(=S)Nc1ccc(Oc2ccnc3ccsc23)c(F)c1.O=C(N=C=S)C1(c2ccccc2)CC1>>O=C(NC(=S)Nc1ccc(Oc2ccnc3ccsc23)c(F)c1)C1(c2ccccc2)CC1",
        "output": "961"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.C[C@H](O)Cn1ncc2ccc(OCc3ccccc3)cc21.[H-].[I-].[Na+].[Na+]>>C[C@@H](Cn1ncc2ccc(OCc3ccccc3)cc21)O[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCOC(C)=O.CCc1ccc(C(=O)N2CCC3(CC2)Oc2cc(C(=O)OC)ccc2-n2cccc23)cc1OC.[Li+].[OH-]>>CCc1ccc(C(=O)N2CCC3(CC2)Oc2cc(C(=O)O)ccc2-n2cccc23)cc1OC",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COc1cc(OC)c(OCc2ccccc2)c(C(=O)NCc2ccc(F)cc2)n1.[Pd]>>COc1cc(OC)c(O)c(C(=O)NCc2ccc(F)cc2)n1",
        "output": "264"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCCCOc1ccc2c(-c3ccc(Br)cc3)nsc2c1.CN1CCNCC1>>CN1CCN(CCCOc2ccc3c(-c4ccc(Br)cc4)nsc3c2)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CO.COCCN.FC(F)(F)COCc1cc(Cl)nc(Cl)n1>>COCCNc1cc(COCC(F)(F)F)nc(Cl)n1",
        "output": "166"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CNCCOCCn1c(CCOC)nc2c(N)nc3ccccc3c21.CS(=O)(=O)Cl.ClCCl>>COCCc1nc2c(N)nc3ccccc3c2n1CCOCCN(C)S(C)(=O)=O",
        "output": "584"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCOP(=O)(Cc1nnc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n12)OCC.C[Si](C)(C)Br>>O=c1[nH]c2cc(C(F)(F)F)ccc2n2c(CP(=O)(O)O)nnc12",
        "output": "535"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)CS(=O)(=O)c1cccc(-c2nc(=O)c3ccccc3s2)n1.CC(C)OC(C)C.O=C(O)C(F)(F)F>>O=C(O)CS(=O)(=O)c1cccc(-c2nc(=O)c3ccccc3s2)n1",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=O.CC#N.CCN(CC)CC.CCOCC.Oc1ccccc1Br.[Cl-].[Cl-].[Mg+2]>>O=Cc1cccc(Br)c1O",
        "output": "451"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COc1cc(F)c(C)cc1[N+](=O)[O-].[Pd]>>COc1cc(F)c(C)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCCCNc1nc(N)nc(C)c1CCCN.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCOC(C)=O.O=C(O)Cc1ccc(CC(=O)O)cc1>>CCCCCNc1nc(N)nc(C)c1CCCNC(=O)Cc1ccc(CC(=O)O)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O=C(c1ccccc1)c1nc(CO)ccc1OCc1ccccc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCc1ccc(OCc2ccccc2)c(C(=O)c2ccccc2)n1",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC1(C)OB(c2ccc(O)cc2)OC1(C)C.CN(C)C=O.Cc1cn2c(Br)cnc2c(NCc2ccc(S(N)(=O)=O)cc2)n1.O.O=C([O-])[O-].[K+].[K+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2Oc2ccccc2P(c2ccccc2)c2ccccc2)cc1>>Cc1cn2c(-c3ccc(O)cc3)cnc2c(NCc2ccc(S(N)(=O)=O)cc2)n1",
        "output": "937"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "FC(F)(F)c1nnc2ccc(N3CCNCC3)nn12.O=Cc1cccc2c1OCCO2>>FC(F)(F)c1nnc2ccc(N3CCN(Cc4cccc5c4OCCO5)CC3)nn12",
        "output": "567"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Cc1cc(Nc2nccc(OC3CCC(OCc4ccccc4)CC3)n2)cc(-c2cnc(C(C)(O)C(F)(F)F)s2)c1.Cl>>Cc1cc(Nc2nccc(OC3CCC(O)CC3)n2)cc(-c2cnc(C(C)(O)C(F)(F)F)s2)c1",
        "output": "178"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1ccc(Cl)cc1C.O=C1CCC(=O)N1Br>>CCOC(=O)c1ccc(Cl)cc1CBr",
        "output": "545"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cccn2c(-c3ccc(Nc4nc5ccc(Cl)cc5s4)cc3)nnc12.[Li+].[OH-]>>O=C(O)c1cccn2c(-c3ccc(Nc4nc5ccc(Cl)cc5s4)cc3)nnc12",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OCC1(CO)CNc2cc(Cl)ccc21>>CC(C)(C)OC(=O)N1CC(CO)(CO)c2ccc(Cl)cc21",
        "output": "827"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(N)cc1N1CCN(C)CC1.O=C(O)Cc1ccc(-c2ccncc2)c2ccccc12>>COc1ccc(NC(=O)Cc2ccc(-c3ccncc3)c3ccccc23)cc1N1CCN(C)CC1",
        "output": "646"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)C(CC1CCCC1)c1ccc(C#CCN2CCOCC2)cc1.O.[Li+].[OH-]>>O=C(O)C(CC1CCCC1)c1ccc(C#CCN2CCOCC2)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)CCC(=O)c1ccc(NC(=O)c2ccc(C)cc2)cc1.[Na+].[OH-]>>Cc1ccc(C(=O)Nc2ccc(C(=O)CCC(=O)O)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cc(C(=O)O)cc2nc(NCc3cc(Cl)ccn3)oc12.F[P-](F)(F)(F)(F)F.OC[C@@H]1C[C@@H](OC2CC2)CN1>>COc1cc(C(=O)N2C[C@H](OC3CC3)C[C@H]2CO)cc2nc(NCc3cc(Cl)ccn3)oc12",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1cc(S(=O)(=O)C2CCC2)ccc1Br.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1cc(S(=O)(=O)C2CCC2)ccc1B1OC(C)(C)C(C)(C)O1",
        "output": "942"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccccc1.NCC1CCNCC1.O=C(Cl)OCc1ccccc1.O=Cc1ccccc1.[K]>>NCC1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "427"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COCC(=O)Cl.Cc1[nH]c2c(-c3cc(C(F)F)ccc3OCC3CC3)ncnc2c1C(=O)N[C@H]1C[C@H](N)[C@@H](C)C1.Cl>>COCC(=O)N[C@H]1C[C@H](NC(=O)c2c(C)[nH]c3c(-c4cc(C(F)F)ccc4OCC4CC4)ncnc23)C[C@@H]1C",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)CCCCO/N=C(/Cn1ccnc1)c1ccccc1.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>O=C(O)CCCCO/N=C(/Cn1ccnc1)c1ccccc1",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(CC)c1ccc(Cl)c2nc(Cl)n(C)c12.Oc1c(Cl)cc(OC(F)(F)F)cc1Br>>CCC(CC)c1ccc(Cl)c2nc(Oc3c(Cl)cc(OC(F)(F)F)cc3Br)n(C)c12",
        "output": "542"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.CO.NN.O>>CC(C)(C)OC(=O)N1CCC(C(=O)NN)CC1",
        "output": "459"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCOCCOCCOCCOCCN1.O=C(Cl)CC12CC3CC(CC(C3)C1)C2>>O=C(CC12CC3CC(CC(C3)C1)C2)N1CCOCCOCCOCCOCCOCC1",
        "output": "125"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCn1c(CO)cccc1=O.CS(=O)(=O)Cl.ClCCl.O>>CCn1c(COS(C)(=O)=O)cccc1=O",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCN(C(C)C)C(C)C.C[C@@H](Nc1ncnc2c1CNCC2)c1ccc(C(F)(F)F)nc1.N#Cc1cc(Cl)ccc1F>>C[C@@H](Nc1ncnc2c1CN(c1ccc(Cl)cc1C#N)CC2)c1ccc(C(F)(F)F)nc1",
        "output": "26"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#CCOc1ccc(C(=O)Cl)cc1OC.C1CCOC1.CCN(CC)CC.CCOC(C)=O.C[C@H](N)C1CCCCC1>>C#CCOc1ccc(C(=O)N[C@@H](C)C2CCCCC2)cc1OC",
        "output": "271"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC1CN(Cc2ccc3c(Cl)ccnc3c2)C(=O)[C@H](C)N1C(=O)OCc1ccccc1.C[Si](C)(C)I>>CC1CN(Cc2ccc3c(Cl)ccnc3c2)C(=O)[C@H](C)N1",
        "output": "568"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.COC(=O)CBr.COc1cc2ncnc(Oc3ccc(O)cc3)c2cc1OC.O=C([O-])O.[H-].[Na+].[Na+]>>COC(=O)COc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1",
        "output": "557"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(C(N)c2ccccc2)c(C)c1.Cc1noc(C)c1-c1ccc2cc(CC(=O)O)ccc2n1.Cl>>Cc1ccc(C(NC(=O)Cc2ccc3nc(-c4c(C)noc4C)ccc3c2)c2ccccc2)c(C)c1",
        "output": "769"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.C[Si](C)(C)C#Cc1c(Cl)cccc1Cl.ClCCl.O=C([O-])[O-].[K+].[K+]>>C#Cc1c(Cl)cccc1Cl",
        "output": "337"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cccc(C(C)C)n1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)c1cccc(CO)n1",
        "output": "711"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCOC(=O)c1cc2nc(Nc3c(Cl)ccc(CNC(=O)C(C)(C)C)c3Cl)n(C)c2cc1N1CCC(C(F)(F)F)CC1.Cl.[Na+].[OH-]>>Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)O)c(N3CCC(C(F)(F)F)CC3)cc21",
        "output": "5"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(NC(=O)OCc2ccccc2)c(=O)n1CC(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(NC(=O)OCc2ccccc2)c(=O)n1CC(=O)O",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNCC1.CCO.Cc1c(C=O)[nH]c2c1C(=O)N(C[C@@H](O)CN1CCOCC1)CCC2.O=C1Cc2cc(Br)ccc2N1>>Cc1c(/C=C2\\C(=O)Nc3ccc(Br)cc32)[nH]c2c1C(=O)N(C[C@@H](O)CN1CCOCC1)CCC2",
        "output": "911"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1cc(Nc2nc(N3CCCC3C(=O)O)nc3c2CCC3)n[nH]1.CCN=C=NCCCN(C)C.CN1CCOCC1.CO.Cl.O.On1nnc2ccccc21>>COC(=O)C1CCCN1c1nc2c(c(Nc3cc(C(C)C)[nH]n3)n1)CCC2",
        "output": "195"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.COCCOCOc1cc(N)ccc1C#N.ClCCCl.O=Cc1ccc(F)cc1.[Na+].[Na+].[OH-]>>COCCOCOc1cc(NCc2ccc(F)cc2)ccc1C#N",
        "output": "359"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.NC(=O)c1cc(-c2ccccc2)cc2c(C3CCN(S(=O)(=O)CCCCl)CC3)c[nH]c12.NS(N)(=O)=O.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>NC(=O)c1cc(-c2ccccc2)cc2c(C3CCN(S(=O)(=O)CCCN4CCCC4)CC3)c[nH]c12",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)[O-].CC(=O)[O-].COC(=O)C(CCCc1ccccc1)CCc1ccc(O)cc1.ClCCl.O.OB(O)c1ccc(F)cc1.[Cu+2].c1ccncc1>>COC(=O)C(CCCc1ccccc1)CCc1ccc(Oc2ccc(F)cc2)cc1",
        "output": "920"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)c1ccc(OCCCCCCCCN2C(=O)c3ccccc3C2=O)cc1.CCCCCCOc1cccc(CN)c1.CCO.NN.O>>CC(C)(C)c1ccc(OCCCCCCCCN)cc1",
        "output": "242"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCS(=O)(=O)NCc1ccc([N+](=O)[O-])cc1.CO.[Pd]>>CCS(=O)(=O)NCc1ccc(N)cc1",
        "output": "507"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1ccc(C2(N)CC2)cc1.Cl.O=C(O)c1cc(F)cnc1N1CC(Oc2cccc(F)c2)C1>>COC(=O)c1ccc(C2(NC(=O)c3cc(F)cnc3N3CC(Oc4cccc(F)c4)C3)CC2)cc1",
        "output": "790"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1cc(N2CCOCC2)nc2c1nc(C)n2Cc1cccc2ccccc12.[Li+].[OH-]>>Cc1nc2c(C(=O)O)cc(N3CCOCC3)nc2n1Cc1cccc2ccccc12",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CC#N.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(C=O)ccc21.CCOC(C)=O.Cl.[Na+]>>CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CN3CCOCC3)ccc21",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC[C@]1(O)CCN[C@H]1C.N#Cc1c(F)cc(F)cc1F.O=C([O-])[O-].[Li+].[Li+]>>CCC[C@]1(O)CCN(c2cc(F)c(C#N)c(F)c2)[C@H]1C",
        "output": "26"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C(=O)O)n1ccc(-c2cc(Cl)ccc2C#N)cc1=O.COC(=O)c1ccc(N)cc1Cl>>COC(=O)c1ccc(NC(=O)C(C)n2ccc(-c3cc(Cl)ccc3C#N)cc2=O)cc1Cl",
        "output": "710"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C1COCCO1.CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(-c3c(F)cnc4c3ccn4COCC[Si](C)(C)C)cn2)C1.Cl>>C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C4(CC#N)CNC4)c3)c(F)cnc21",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCc1c(OCCCCOCCCCOc2c(C(C)=O)ccc(OCC(=O)OCC)c2CCC)ccc(C(C)=O)c1O.CO.[Na+].[OH-]>>CCCc1c(OCCCCOCCCCOc2c(C(C)=O)ccc(OCC(=O)O)c2CCC)ccc(C(C)=O)c1O",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC[SiH](CC)CC.CN(CCC(c1ccccc1)c1ccc2c(ccn2S(C)(=O)=O)c1)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CNCCC(c1ccccc1)c1ccc2c(ccn2S(C)(=O)=O)c1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C[Si](C)(C)CCOCn1ccc(Nc2cncc(CN3CCN(C(=O)c4cccc(C(F)(F)F)c4F)CC3)n2)n1.O.O=C(O)C(F)(F)F>>O=C(c1cccc(C(F)(F)F)c1F)N1CCN(Cc2cncc(Nc3cc[nH]n3)n2)CC1",
        "output": "813"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F.Cl.O.[Li+].[OH-]>>O=C(O)c1cc(Cc2n[nH]c(=O)c3c2NCCC3)ccc1F",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CCCCBr.O=C([O-])[O-].Oc1ccccc1.[K+].[K+]>>CCCCOc1ccccc1",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@H](NC(=O)c1cnc2n1[C@](C)(Cc1ccc(Br)cc1)C(=O)N2c1cc(Cl)cc(Cl)c1)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>C[C@H](NC(=O)c1cnc2n1[C@](C)(Cc1ccc(Br)cc1)C(=O)N2c1cc(Cl)cc(Cl)c1)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "N=C(NN)c1ncccc1C(F)(F)F.O=Cc1cccc2ccccc12>>FC(F)(F)c1cccnc1-c1n[nH]c(-c2cccc3ccccc23)n1",
        "output": "994"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)C(C)(C)Sc1ccc(CN(Cc2ccco2)Cc2nc(Cc3ccc(F)cc3)no2)cc1.Cl>>CC(C)(Sc1ccc(CN(Cc2ccco2)Cc2nc(Cc3ccc(F)cc3)no2)cc1)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C.CC(=O)O.CC(C)c1ccccc1Nc1ccc(-c2ccccc2)cc1[N+](=O)[O-].CCO.[Pd]>>CC(C)c1ccccc1Nc1ccc(-c2ccccc2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCC(N)C(=O)Nc1cn(C(C)(C)CN2CCOCC2)cn1.O=C(O)Cc1cccc(C(F)(F)F)c1>>CCCC(NC(=O)Cc1cccc(C(F)(F)F)c1)C(=O)Nc1cn(C(C)(C)CN2CCOCC2)cn1",
        "output": "133"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN(C)C=O.COC[C@@H](C)Oc1cc(OCc2ccccc2)cc(C(=O)O)c1.ClCCl.Cn1ccc(N)n1.O=C(Cl)C(=O)Cl>>COC[C@@H](C)Oc1cc(OCc2ccccc2)cc(C(=O)Nc2ccn(C)n2)c1",
        "output": "917"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc(CC(=O)OC(C)(C)C)ccc1N.ClCCl.O=C=Nc1ccccc1>>COc1cc(CC(=O)OC(C)(C)C)ccc1NC(=O)Nc1ccccc1",
        "output": "473"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1ccc(C(N)=NO)cc1.F[P-](F)(F)(F)(F)F.O=C(O)CC12CC3CC(CC(C3)C1)C2>>Cc1ccc(-c2noc(CC34CC5CC(CC(C5)C3)C4)n2)cc1",
        "output": "926"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1ccc(CCN2CCNCC2)cc1.ClCCl.N.O=C(Cl)Cc1ccc(Cl)cc1.c1ccncc1>>CCOC(=O)c1ccc(CCN2CCN(C(=O)Cc3ccc(Cl)cc3)CC2)cc1",
        "output": "125"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Nc1ccc(C(=O)O)cc1.O=[N+]([O-])O>>CC(=O)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CN(c1ccc(-c2ccc(F)cc2OCc2ccccc2)nn1)C1CC(C)(C)NC(C)(C)C1.CO.ClCCl.[Pd]>>CN(c1ccc(-c2ccc(F)cc2O)nn1)C1CC(C)(C)NC(C)(C)C1",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1conc1-c1ccc(CCl)cc1.O.O.[Li+].[OH-]>>O=C(O)c1conc1-c1ccc(CCl)cc1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)C1(CCCn2c(=O)ccc3ccc(OC)cc32)CCN(CCSc2cccc(F)c2)CC1.[Na+].[OH-]>>COc1ccc2ccc(=O)n(CCCC3(C(=O)O)CCN(CCSc4cccc(F)c4)CC3)c2c1",
        "output": "281"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)[C@H](CNC(=O)c1cccc(C)c1)NC(=O)c1c(C)nc(NCCCc2cccc(O)c2)nc1C.O.O.O=S(=O)([O-])O.[K+].[Li+].[OH-]>>Cc1cccc(C(=O)NC[C@H](NC(=O)c2c(C)nc(NCCCc3cccc(O)c3)nc2C)C(=O)O)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOCC.COC(=O)Cn1ccnc1C.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>Cc1nccn1CCO",
        "output": "343"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(Cc1ccccc1)c1[nH]c2ccc(OC)cc2c1SC(C)(C)C.CI>>CCOC(=O)C(Cc1ccccc1)c1c(SC(C)(C)C)c2cc(OC)ccc2n1C",
        "output": "191"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.O=C([O-])O.OCCOCCNCc1ccccc1.[Na+]>>CN(CCOCCO)Cc1ccccc1",
        "output": "69"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1cccc2c1ccn2C(C)C(=O)OC(C)(C)C.[Na+].[OH-]>>Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1cccc2c1ccn2C(C)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CC=C(c2ccc(NC(=O)Nc3ccc4nccn4c3)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(Nc1ccc(C2=CCNCC2)cc1)Nc1ccc2nccn2c1",
        "output": "800"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)c1n[nH]c2c(NCc3ccccc3)nc(Cl)nc12.CN1CCCC1=O.NCCN>>CC(C)c1n[nH]c2c(NCc3ccccc3)nc(NCCN)nc12",
        "output": "544"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(N=[N+]=[N-])c1oc2ccccc2c1-c1ccccc1.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(N)c1oc2ccccc2c1-c1ccccc1",
        "output": "89"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(O)(CN)c1ccc(OCc2ccccc2)cc1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=Cc1ccccc1.[BH4-].[Na+]>>CC(O)(CNCc1ccccc1)c1ccc(OCc2ccccc2)cc1",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(CCN)C(=O)O.CO.C[Si](C)(C)Cl.Cl>>COC(=O)C(C)(C)CCN",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C(=O)Cl.Cc1ncc(-c2ccnc(NC3CCNCC3)n2)n1C(C)C.ClCCl.NC(CO)(CO)CO>>Cc1ncc(-c2ccnc(NC3CCN(C(=O)N(C)C)CC3)n2)n1C(C)C",
        "output": "258"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C#N)c1ccc(O)c([N+](=O)[O-])c1.CCO.Cl.ClC(Cl)Cl.O.[Na+].[OH-]>>CC(C#N)c1ccc(O)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(CCCCCCCBr)on1.Cc1nc(-c2ccc(O)cc2)cs1>>Cc1cc(CCCCCCCOc2ccc(-c3csc(C)n3)cc2)on1",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(Cl)cc2c1NC(c1cccc(-c3ccc(C(C)C)cc3)c1)C(C)(C)C2.Cl.O.[Na+].[OH-]>>CC(C)c1ccc(-c2cccc(C3Nc4c(cc(Cl)cc4C(=O)O)CC3(C)C)c2)cc1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.CC(=O)[O-].CC(=O)[O-].CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)NCCc4ccc(Cl)cc4Br)cc3)c(Cl)cc21.Cc1ccccc1.O.O=P([O-])([O-])[O-].OB(O)C1CC1.[K+].[K+].[K+].[Pd+2]>>CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)NCCc4ccc(Cl)cc4C4CC4)cc3)c(Cl)cc21",
        "output": "956"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(Cc2ccc[nH]2)CC1.CO.ClC(Cl)Cl>>c1c[nH]c(CC2CCNCC2)c1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C([O-])O.O=[N+]([O-])c1ccc(CCNC2CC2)cc1.[Na+]>>CC(C)(C)OC(=O)N(CCc1ccc([N+](=O)[O-])cc1)C1CC1",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OCc1nc2ccc(Oc3cc(C)c(OC(C)=O)c(C)c3C)nc2n1C.CO.C[O-].O.[Na+]>>CC(=O)Oc1c(C)cc(Oc2ccc3nc(CO)n(C)c3n2)c(C)c1C",
        "output": "348"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Br)cc1F.SCc1ccccc1.[Cs+].[Cs+]>>O=[N+]([O-])c1ccc(Br)cc1SCc1ccccc1",
        "output": "503"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc2[nH]c(SCc3nccc(N4CCCCC4)n3)nc2c1.ClCCl.N.O=C(OO)c1cccc(Cl)c1>>COc1ccc2[nH]c(S(=O)Cc3nccc(N4CCCCC4)n3)nc2c1",
        "output": "595"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCC.NCCCC(=O)O.O=C(c1ccc(S(=O)(=O)Cl)cc1)c1cccs1.[Na+].[OH-]>>O=C(O)CCCNS(=O)(=O)c1ccc(C(=O)c2cccs2)cc1",
        "output": "43"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(c2ccc(C)cc2)=CCC3(C)C)cc1.O.O.[Li]O>>Cc1ccc(C2=CCC(C)(C)c3ccc(C#Cc4ccc(C(=O)O)cc4)cc32)cc1",
        "output": "5"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNCC1.CCO.Cc1cc(C(=O)N2CC[C@H](N(C)C)C2)c(C=O)[nH]1.O=C1Cc2c(cccc2-c2cccc(Cl)c2)N1>>Cc1cc(C(=O)N2CC[C@H](N(C)C)C2)c(C=C2C(=O)Nc3cccc(-c4cccc(Cl)c4)c32)[nH]1",
        "output": "440"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.N#Cc1cc(Br)ccc1F.OCC1CC1.[H-].[Na+]>>N#Cc1cc(Br)ccc1OCC1CC1",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O=C(O)C1CC1c1ccccc1.O=S(=O)(O)O>>COC(=O)C1CC1c1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CN(C)C=O.CS(=O)(=O)OCCOc1ccc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)cc1>>Clc1ccc(-c2ccc(C#Cc3ccc(OCCN4CCCCC4)cc3)nc2)cc1",
        "output": "496"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.COC(=O)c1nc(Br)cnc1N.COCCOC.CS(=O)(=O)c1ccc(B(O)O)cc1.Cl[Pd]Cl.O=C([O-])[O-].[Na+].[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1nc(-c2ccc(S(C)(=O)=O)cc2)cnc1N",
        "output": "876"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.CN(C)c1ccncc1.O=C(NC[C@H]1CN(c2ccc(N3CCOC(CCCO)C3=O)cc2)C(=O)O1)c1ccc(Cl)s1.O=C1CCC(=O)O1.c1ccncc1>>O=C(O)CCC(=O)OCCCC1OCCN(c2ccc(N3C[C@H](CNC(=O)c4ccc(Cl)s4)OC3=O)cc2)C1=O",
        "output": "139"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNCCN1.CN(C)C=O.COc1ccc2nc(Cl)ccc2c1.O=C([O-])O.[Na+]>>COc1ccc2nc(N3CCNCC3)ccc2c1",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(C(F)(F)F)nn1C(CC(=O)O)C(=O)N1CCCc2c1cnn2-c1ccc(F)cc1.F[P-](F)(F)(F)(F)F.N>>Cc1cc(C(F)(F)F)nn1C(CC(N)=O)C(=O)N1CCCc2c1cnn2-c1ccc(F)cc1",
        "output": "313"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CNC.Cc1cc(=O)n(CCN2CCC(N(Cc3ccc4c(c3)OCCO4)C(=O)OC(C)(C)C)CC2)c2cc(C(=O)O)ccc12.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O>>Cc1cc(=O)n(CCN2CCC(N(Cc3ccc4c(c3)OCCO4)C(=O)OC(C)(C)C)CC2)c2cc(C(=O)N(C)C)ccc12",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN.CCOC(=O)Cn1nc(C)c(-c2ccc(C(F)(F)F)cc2C=O)c1C>>CCNCc1cc(C(F)(F)F)ccc1-c1c(C)nn(CC(=O)OCC)c1C",
        "output": "468"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(-c4ccccc4O)ncc(F)c3c2)c(OC)c1.N#CCBr.O=C([O-])[O-].[Cs+].[Cs+]>>COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(-c4ccccc4OCC#N)ncc(F)c3c2)c(OC)c1",
        "output": "802"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.Cc1ccc(S(=O)(=O)n2cc(-c3nc(NC(C)C)ncc3C#N)c3cc(Nc4ccccc4)cnc32)cc1.O.[Li+].[OH-]>>CC(C)Nc1ncc(C#N)c(-c2c[nH]c3ncc(Nc4ccccc4)cc23)n1",
        "output": "949"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CN(C)C=O.COCC#Cc1cc(Cl)c(N)c2c1OCO2.COc1cc2c(Cl)ncnc2cc1OCCCCCl.C[Si](C)(C)[N-][Si](C)(C)C.[Cl-].[NH4+].[Na+]>>COCC#Cc1cc(Cl)c(Nc2ncnc3cc(OCCCCCl)c(OC)cc23)c2c1OCO2",
        "output": "352"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc2cc[nH]c2c1.CCO.Cc1ccccc1.O.O=C([O-])O.OB(O)c1ccccc1.[Cl-].[Na+].[Na+]>>c1ccc(-c2ccc3cc[nH]c3c2)cc1",
        "output": "909"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.N#Cc1ccc(F)cc1.O.[Na+].[OH-].c1cn[nH]c1>>N#Cc1ccc(-n2cccn2)cc1",
        "output": "751"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1sc(-c2cn(CCc3ccc(F)cc3)nn2)nc1C.CCOC(=O)c1sc(-c2cn(Cc3ccccc3)nn2)nc1C>>Cc1nc(-c2cn(CCc3ccc(F)cc3)nn2)sc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)O.CCOC(=O)CC1CCN(C(=O)CC2OC(c3cccc(OC)c3OC)c3cc(Cl)ccc3-n3cccc32)CC1.CO.ClC(Cl)Cl.O.O=C([O-])[O-].[K+].[K+]>>COc1cccc(C2OC(CC(=O)N3CCC(CC(=O)O)CC3)c3cccn3-c3ccc(Cl)cc32)c1OC",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)/C=C/c1ccccc1[C@@H](C)OC[C@H](O)CN1CCC[C@H]1Cc1ccc(C)c(F)c1.[Na+].[OH-]>>Cc1ccc(C[C@@H]2CCCN2C[C@@H](O)CO[C@H](C)c2ccccc2/C=C/C(=O)O)cc1F",
        "output": "58"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CCO.CN(C)C=O.Cc1cc(F)ccc1B(O)O.Cl[Pd]Cl.O.O=C([O-])[O-].O=c1c(Br)nc2cccnc2n1CC1CC1.[Na+].[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(F)ccc1-c1nc2cccnc2n(CC2CC2)c1=O",
        "output": "876"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1c[nH]c2ncc(Br)c(F)c12.O=C(Cl)c1ccc(F)cc1.c1ccncc1>>O=C(Nc1c[nH]c2ncc(Br)c(F)c12)c1ccc(F)cc1",
        "output": "501"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)S(=O)(=O)c1cc(C(=O)O)c(F)c(F)c1F.CO.Cc1ccc(S(=O)(=O)O)cc1>>COC(=O)c1cc(S(=O)(=O)N(C)C)c(F)c(F)c1F",
        "output": "33"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)[Si](Cl)(C(C)C)C(C)C.CN(C)C=O.OCc1cc(Cl)ccc1I.c1c[nH]cn1>>CC(C)[Si](OCc1cc(Cl)ccc1I)(C(C)C)C(C)C",
        "output": "193"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)C1N(c2ccccc2)C(=O)CCN1S(=O)(=O)c1ccc(OC)c(OC)c1.CO.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li+].[OH-]>>COc1ccc(S(=O)(=O)N2CCC(=O)N(c3ccccc3)C2C(=O)O)cc1OC",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Cl.Clc1ccc(C(CC2OCCO2)Cn2ccnc2)cc1Cl>>O=CCC(Cn1ccnc1)c1ccc(Cl)c(Cl)c1",
        "output": "740"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.O=[N+]([O-])c1ccc2c(c1)CCN2>>CC(C)(C)OC(=O)N1CCc2cc([N+](=O)[O-])ccc21",
        "output": "827"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1cc(-c2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)nc2-c2ccccn2)ccn1.CCOC(C)=O.Cc1ccccc1.O=C([O-])[O-].O=Cc1ccc(B(O)O)cc1.[Na+].[Na+]>>O=Cc1ccc(-c2cc(-c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)nc3-c3ccccn3)ccn2)cc1",
        "output": "869"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(Oc2ccnc(Cl)n2)c2ccccc12.CN(C)C=O.COCCOCCOCCOc1cc(N)cc(OC)c1>>COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)OC(C)(C)C)c4ccccc34)n2)cc(OC)c1",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1CCNCC1.O=C(O)c1cc2nc(-c3cccc4[nH]ncc34)nc(N3CCOCC3)c2s1>>CN1CCN(C(=O)c2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1",
        "output": "857"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COCCOCCOC.Cc1nc(Cl)c([N+](=O)[O-])c(NCCOCCCc2cccnc2)c1C.Oc1ccccc1.[H-].[Na+]>>Cc1nc(Oc2ccccc2)c([N+](=O)[O-])c(NCCOCCCc2cccnc2)c1C",
        "output": "516"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cl.O=C(O)CCC(=O)c1ccccc1O>>COC(=O)CCC(=O)c1ccccc1O",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.N#Cc1cccc(I)c1.O=C([O-])[O-].OCCO.Sc1ccccc1.[Cu]I.[K+].[K+]>>N#Cc1cccc(Sc2ccccc2)c1",
        "output": "565"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C(=O)Cc1ccc(C#N)cc1.[Na+].[OH-]>>N#Cc1ccc(CC(=O)C(=O)O)cc1",
        "output": "472"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCOC(=O)c1c(CC(C)(C)C)nc2cc(C(F)(F)F)ccc2c1C.CO.[Li+].[OH-]>>Cc1c(C(=O)O)c(CC(C)(C)C)nc2cc(C(F)(F)F)ccc12",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCn1c(=O)c2c(C)n(C3CCCCO3)nc2c2cc(C#CCN3CCCC3)ccc21.CO.Cl>>CCn1c(=O)c2c(C)[nH]nc2c2cc(C#CCN3CCCC3)ccc21",
        "output": "689"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)C=O.ClCCl.O.O=C(Cl)C(=O)Cl.O=C(O)CCC1(C(F)(F)F)CC1.[Cl-].[NH4+].[Na+].[OH-]>>NC(=O)CCC1(C(F)(F)F)CC1",
        "output": "313"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.Nc1ccc(C2CCNCC2)cc1.O=C(Cl)Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1>>Nc1ccc(C2CCN(C(=O)Oc3ccc(Oc4ccc(C(F)(F)F)cn4)cc3)CC2)cc1",
        "output": "219"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNC1.ClCCl.O=C([O-])[O-].O=S(=O)(Cl)c1ccc(Br)cc1.[K+].[K+]>>O=S(=O)(c1ccc(Br)cc1)N1CCC1",
        "output": "99"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1Cc2c[nH]nc2C1.CCCCCC.CCOC(C)=O.CN[C@@H]1CCCC[C@H]1NC.C[Si](C)(C)CCOCn1c(O[C@@H]2CO[C@@H]3[C@H](O)CO[C@@H]32)nc2nc(-c3ccc(Br)cc3)c(Cl)cc21.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+].c1cn[nH]c1>>CC(C)(C)OC(=O)N1Cc2cn(-c3ccc(-c4nc5nc(O[C@@H]6CO[C@@H]7[C@H](O)CO[C@@H]76)n(COCC[Si](C)(C)C)c5cc4Cl)cc3)nc2C1",
        "output": "919"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N(C)C.CN(C[C@@H]1CC[C@@H](COCCCCBr)CC1)C(=O)Oc1ccc(Cl)cc1.CNCCO>>CN(CCO)CCCCOC[C@@H]1CC[C@@H](CN(C)C(=O)Oc2ccc(Cl)cc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.COc1c2ccc(N)cc2nn1CC(C)(C#N)NC(=O)c1ccc(OC(F)(F)F)cc1>>COc1c2ccc(NC(C)=O)cc2nn1CC(C)(C#N)NC(=O)c1ccc(OC(F)(F)F)cc1",
        "output": "9"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N1CCC(Oc2ccc(C3(C(=O)O)CCOCC3)cc2)CC1.CCO.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CNC.CNC.Cl.F[P-](F)(F)(F)(F)F.O.c1ccncc1>>CC(C)N1CCC(Oc2ccc(C3(C(=O)N(C)C)CCOCC3)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C([O-])[O-].OC1(c2cccc(C(F)(F)F)c2)CCNCC1.[K+].[K+]>>OC1(c2cccc(C(F)(F)F)c2)CCN(Cc2ccccc2)CC1",
        "output": "248"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCNCC1.ClCCCl.O=Cc1c(Cl)cccc1N1CCOCC1.[Na+]>>CC(C)(C)OC(=O)N1CCN(Cc2c(Cl)cccc2N2CCOCC2)CC1",
        "output": "567"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO.COC(=O)Cc1ccccc1OCCCc1cn(-c2ccc(Cl)cn2)nc1C(C)C.Cl.[Na+].[OH-]>>CC(C)c1nn(-c2ccc(Cl)cn2)cc1CCCOc1ccccc1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Nc1ccc2c(c1)nc(C(C)(C)C)n2CC1CCC(F)(F)CC1.CCO.Cl>>CC(C)(C)c1nc2cc(N)ccc2n1CC1CCC(F)(F)CC1",
        "output": "66"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCC1CC1.CC(C)(C)OC(=O)Cn1cc(-c2ccccc2)[nH]c1=O.CC(C)=O.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)(C)OC(=O)Cn1cc(-c2ccccc2)n(CC2CC2)c1=O",
        "output": "495"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Cc1cc(Br)ccc1N.O.O=C(Cl)C1CC1>>Cc1cc(Br)ccc1NC(=O)C1CC1",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[Si](C)(C)[N-][Si](C)(C)C.Nc1ncnc2c1c(I)nn2-c1ccc([N+](=O)[O-])cc1.O.[Li+]>>CC(C)(C)OC(=O)Nc1ncnc2c1c(I)nn2-c1ccc([N+](=O)[O-])cc1",
        "output": "849"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1Nc1cc(F)ccc1[N+](=O)[O-].CCO.[Pd]>>CC(=O)O[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1Nc1cc(F)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)CC1NC(C(=O)O)C(c2cc(F)cc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12.CCN(C(C)C)C(C)C.COc1cc(C#N)ccc1N.O=C(O)C(F)(F)F.O=P(Cl)(c1ccccc1)c1ccccc1>>COc1cc(C#N)ccc1NC(=O)C1NC(CC(C)(C)C)C2(C(=O)Nc3cc(Cl)ccc32)C1c1cc(F)cc(Cl)c1",
        "output": "563"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC(C)(C)OC(=O)Nc1ccc(C2CNC(=O)NC2)cc1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)Nc1ccc(C2CNC(=O)NC2)cc1Br",
        "output": "4"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)C=Cc1cccc(S(=O)(=O)Nc2ccccc2)c1.[Na+].[OH-]>>O=C(O)C=Cc1cccc(S(=O)(=O)Nc2ccccc2)c1",
        "output": "58"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)c1cc(Br)cc(C(C)C)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)c1cc(B2OC(C)(C)C(C)(C)O2)cc(C(C)C)c1",
        "output": "942"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1ccccc1.CC(=O)O.CN(C)C=O.OC1CN(C(c2ccccc2)c2ccccc2)C1.[H-].[Na+]>>c1ccc(COC2CN(C(c3ccccc3)c3ccccc3)C2)cc1",
        "output": "464"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CC(C(=O)O)C(c2ccc(F)cc2)C1>>CC(C)(C)OC(=O)N1CC(CO)C(c2ccc(F)cc2)C1",
        "output": "231"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br[Mg]c1ccccc1.C1CCOC1.O=Cc1cccc(Br)c1F>>OC(c1ccccc1)c1cccc(Br)c1F",
        "output": "309"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.Cl.ClC(Cl)Cl.NC1CC2C3CC4C2C4C13.S=C=Nc1ccc(Cl)cc1>>S=C(Nc1ccc(Cl)cc1)NC1CC2C3CC4C2C4C13",
        "output": "113"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccccc1C(=O)c1cccc2c1ccn2S(=O)(=O)c1ccc(C)cc1.Cl.O=C([O-])[O-].[Na+].[Na+].c1ccncc1>>Cc1ccc(S(=O)(=O)n2ccc3c(C(=O)c4ccccc4O)cccc32)cc1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1cncc(N2CCOCC2)c1.C1COCCO1.CC1(C)OB(c2cnc3c(c2)CCCN3C(N)=O)OC1(C)C.O.O=C([O-])[O-].[Na+].[Na+]>>NC(=O)N1CCCc2cc(-c3cncc(N4CCOCC4)c3)cnc21",
        "output": "967"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COc1cc(N2CCN(C[C@H](C)O)CC2)ccc1-c1cnc2c(c1)c(-c1cnn(Cc3cccc(F)c3)c1)cn2S(=O)(=O)c1ccc(C)cc1.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4ccc(C5CCNCC5)cc4)cnc32)cc1.Cl.O.[Li+].[OH-]>>COc1cc(N2CCN(C[C@H](C)O)CC2)ccc1-c1cnc2[nH]cc(-c3cnn(Cc4cccc(F)c4)c3)c2c1",
        "output": "949"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC1(N)CNC1.CS(=O)(=O)O.CS(=O)(=O)O.Cn1cc(C(=O)O)c(=O)c2cc3cc(F)c(F)cc3nc21>>CCC1(N)CN(c2cc3nc4c(cc3cc2F)c(=O)c(C(=O)O)cn4C)C1",
        "output": "676"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.O.O=Cc1ccc2[nH]cc(CCN3CCN(c4nccc5[nH]ccc45)CC3)c2c1.[BH4-].[Na+]>>OCc1ccc2[nH]cc(CCN3CCN(c4nccc5[nH]ccc45)CC3)c2c1",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[C@@H]1CN(c2ccc(F)cc2C(F)(F)F)CCN1S(=O)(=O)c1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)c2ccccc12.ClCCl.O=C(O)C(F)(F)F>>C[C@@H]1CN(c2ccc(F)cc2C(F)(F)F)CCN1S(=O)(=O)c1ccc(N2CCNCC2)c2ccccc12",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.Cc1cc(C)cc(-c2[nH]c3ccc(-n4nnn(C)c4=O)cc3c2CCN(CCCCc2cccnc2)Cc2ccccc2)c1.O.[H][H].[OH-].[OH-].[Pd+2]>>Cc1cc(C)cc(-c2[nH]c3ccc(-n4nnn(C)c4=O)cc3c2CCNCCCCc2cccnc2)c1",
        "output": "84"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1[nH]c2cc(Cl)cc(Cl)c2c1NCS(=O)(=O)c1ccccc1.Cl.O.O.[Li+].[OH-]>>O=C(O)c1[nH]c2cc(Cl)cc(Cl)c2c1NCS(=O)(=O)c1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[O-].CCOC(C)=O.Cc1ccccc1C.Clc1cccc(Br)c1Cl.O.[Na+].c1ccc(Nc2ccccc2)cc1>>Clc1cccc(N(c2ccccc2)c2ccccc2)c1Cl",
        "output": "894"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCCOc1cc(C[C@@H]2CS(=O)(=O)C[C@H](N(Cc3cccc(C(C)(C)C)c3)C(=O)OC(C)(C)C)[C@H]2O)ccc1N.O=C([O-])O.O=C1CCC(=O)N1Cl.[Na+]>>CCCOc1cc(C[C@@H]2CS(=O)(=O)C[C@H](N(Cc3cccc(C(C)(C)C)c3)C(=O)OC(C)(C)C)[C@H]2O)cc(Cl)c1N",
        "output": "121"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COB(OC)OC.Cl.N#Cc1ccc(Br)cc1.[Li]CCCC>>N#Cc1ccc(B(O)O)cc1",
        "output": "789"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1[nH]cc2c1CCCC2.CO.[Na+].[OH-]>>O=C(O)c1[nH]cc2c1CCCC2",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN1c2ncc(CCO)cc2C(=O)Nc2c(C)cc(Cl)nc21.CCOC(=O)N=NC(=O)OCC.CCOC(C)=O.Oc1cccc2ncccc12.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCN1c2ncc(CCOc3cccc4ncccc34)cc2C(=O)Nc2c(C)cc(Cl)nc21",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)SCC(C(=O)O)C(C)c1ccccc1.CCCC[C@H](N)C(=O)OCc1ccccc1>>CCCC[C@H](NC(=O)C(CSC(C)=O)C(C)c1ccccc1)C(=O)OCc1ccccc1",
        "output": "132"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC[SiH](CC)CC.ClCCl.Cn1nnnc1-c1cc2c3c(cccc3c1)C(=O)N(CCCC(=O)OC(C)(C)C)C2=O.O=C(O)C(F)(F)F>>Cn1nnnc1-c1cc2c3c(cccc3c1)C(=O)N(CCCC(=O)O)C2=O",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)c1ccc(Nc2cccc(-c3cccnc3)c2)c([N+](=O)[O-])c1.CCO.CCOCC.ClCCl.[Pd]>>CC(=O)c1ccc(Nc2cccc(-c3cccnc3)c2)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cc1cc(Cl)ccc1Oc1ccc([N+](=O)[O-])cn1.[H][H].[OH-].[OH-].[Pd+2]>>Cc1cc(Cl)ccc1Oc1ccc(N)cn1",
        "output": "269"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCl.II.OCCc1ccc(Br)cc1.c1c[nH]cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Brc1ccc(CCI)cc1",
        "output": "670"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)c1ccc(Br)cc1.COCCOC.N#N.O.O=C([O-])[O-].OB(O)c1ccccc1Br.[K+].[K+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)c1ccc(-c2ccccc2Br)cc1",
        "output": "837"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.COc1cccc(OC)c1C(=O)Cl.Cl.ClCCl.NC1CCCC1Cc1ccc2ccccc2n1.O>>COc1cccc(OC)c1C(=O)NC1CCCC1Cc1ccc2ccccc2n1",
        "output": "271"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)c1cc(OCC=C(Cl)Cl)cc(Cl)c1O.CCOC(=O)N=NC(=O)OCC.OCCCOc1ccc(C(F)(F)F)cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(=O)c1cc(OCC=C(Cl)Cl)cc(Cl)c1OCCCOc1ccc(C(F)(F)F)cn1",
        "output": "478"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)C1(C)CC1CC1CC=C(C)C1(C)C.[BH4-].[Na+]>>CC1=CCC(CC2CC2(C)C(C)O)C1(C)C",
        "output": "91"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC(CC(=O)O)Cc1cccc(Br)c1.CO.ClCCCl.On1nnc2ccccc21>>COC(=O)CC(Cc1cccc(Br)c1)NC(=O)OC(C)(C)C",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.N#Cc1ccc2c(c1)CC(CO)C2>>N#Cc1ccc2c(c1)CC(C=O)C2",
        "output": "142"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.COC(=O)c1sc(Nc2cc(OCc3ccc(OC)cc3)ccc2[N+](=O)[O-])cc1O[C@H](C)c1ccccc1Cl.[H][H].[Pt]>>COC(=O)c1sc(Nc2cc(OCc3ccc(OC)cc3)ccc2N)cc1O[C@H](C)c1ccccc1Cl",
        "output": "202"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.C[Si](C)(C)CCOCn1nc(/C=C/c2ccccc2)c2ccc(C=O)cc21.[F-]>>O=Cc1ccc2c(/C=C/c3ccccc3)n[nH]c2c1",
        "output": "813"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](OCCO)(c1ccccc1)c1ccccc1.CCN(CC)CC.COC(C)(C)C.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)[Si](OCCOS(=O)(=O)C(F)(F)F)(c1ccccc1)c1ccccc1",
        "output": "582"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCC/C=C/c1cccc(C(c2c[nH]c3ccccc23)C(C)c2ccc(C(=O)NCCC(=O)OC)cc2)c1.CSCCC1NC(=O)C(NC(=O)C(CCCNC(=N)N)NC(=O)C(CCSC)NC(=O)C(NC(=O)C(N)CC(=O)O)C(C)O)CSSCC(C(=O)NC(Cc2c[nH]c3ccccc23)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)O)C(C)C)NC(=O)C2CCCN2C(=O)C(CCCNC(=N)N)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(C(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(C(C)C)NC1=O>>CCCC/C=C/c1cccc(C(c2c[nH]c3ccccc23)C(C)c2ccc(C(=O)NCCC(=O)O)cc2)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)C(=O)Cl.Oc1cccc(I)c1.[H-].[Na+]>>CCN(CC)C(=O)Oc1cccc(I)c1",
        "output": "425"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1c(N2CCCC(=C(F)CNC(=O)[C@@H]3CCCN3)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12.Cl.F[P-](F)(F)(F)(F)F>>COc1c(N2CCCC(=C(F)CNC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12",
        "output": "297"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCCNCC1.CCCCOc1nc(N)c2nc(OC)n(CCCCCCCl)c2n1>>CCCCOc1nc(N)c2nc(OC)n(CCCCCCN3CCCCCC3)c2n1",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.ClCCl.Nc1ccc(Cl)c(Cl)c1.O>>CC(C)(C)OC(=O)N1CCC(C(=O)Nc2ccc(Cl)c(Cl)c2)CC1",
        "output": "365"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CC[C@H](CNC)c1ccc(F)cc1.CCN(C(C)C)C(C)C.ClCCl.N#Cc1cc2c(c(C(=O)Cl)c1)CCCC2>>C=CC[C@H](CN(C)C(=O)c1cc(C#N)cc2c1CCCC2)c1ccc(F)cc1",
        "output": "201"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1ccc(Cl)cc1.Nc1nc(Cl)cc(-c2ccccc2)n1>>Nc1nc(Nc2ccc(Cl)cc2)cc(-c2ccccc2)n1",
        "output": "352"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Brc1cc(-c2c(-c3ccccn3)nc3ccccn23)ccn1.O=Cc1ccc(B(O)O)cc1>>O=Cc1ccc(-c2cc(-c3c(-c4ccccn4)nc4ccccn34)ccn2)cc1",
        "output": "869"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COc1cccc(CC(=O)Nc2ccccc2)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1cccc(CCNc2ccccc2)c1",
        "output": "112"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc(-n2c(-c3ccc(C(=O)NC(c4ccccc4)c4ccccc4)s3)nc3ccccc32)cc1.ClCCl>>O=C(NC(c1ccccc1)c1ccccc1)c1ccc(-c2nc3ccccc3n2-c2ccc(O)cc2)s1",
        "output": "402"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC1COCCC1=O.CCN(CC)CC.Cc1cc(C(F)(F)F)cc(N2CCN(C(=O)[C@@]3(C(C)C)CC[C@@H](N)C3)CC2)n1.ClCCl.[Na+]>>Cc1cc(C(F)(F)F)cc(N2CCN(C(=O)[C@@]3(C(C)C)CC[C@@H](NC4CCOCC4C)C3)CC2)n1",
        "output": "236"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(c1ccccc1-c1ccccc1)C(C)(C)C.Cc1ccccc1.Cc1oc(-c2ccc(Br)cc2)nc1CCOCc1ccccc1.O=P([O-])([O-])[O-].Oc1ccccc1.[K+].[K+].[K+].[Pd+2]>>Cc1oc(-c2ccc(Oc3ccccc3)cc2)nc1CCOCc1ccccc1",
        "output": "238"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.NCCN1CCCCC1CN1CCCC1.O=C1Nc2cccnc2N(C(=O)Cl)c2ccccc21>>O=C1Nc2cccnc2N(C(=O)NCCN2CCCCC2CN2CCCC2)c2ccccc21",
        "output": "454"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[O-].CS(C)=O.Cc1ccc2c(=O)[nH]c(Cl)nc2n1.Cl.OCCCCCc1ccccc1.[K+]>>Cc1ccc2c(=O)[nH]c(OCCCCCc3ccccc3)nc2n1",
        "output": "213"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1ncnc2c1c(NCc1ccc(C(F)(F)F)cc1)cc(=O)n2OCc1ccccc1.[C].[H][H].[OH-].[OH-].[Pd+2]>>Cc1ncnc2c1c(NCc1ccc(C(F)(F)F)cc1)cc(=O)n2O",
        "output": "630"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccc(Br)cc1.C1COCCN1.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>Brc1ccc(CN2CCOCC2)cc1",
        "output": "248"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)O.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc(C(=O)O)cc1.O.[Na+].[OH-]>>CC(C)(C)OC(=O)Nc1ccc(C(=O)O)cc1",
        "output": "735"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#C[C@@](C)(O)c1cc(C)on1.NC(=O)c1cc2c(s1)-c1cc(Br)c(F)cc1OCC2>>Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)OCCc2cc(C(N)=O)sc2-3)no1",
        "output": "659"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)Nc1nccc2c1ccn2-c1ccc(NC(=O)CC(=O)Nc2ccc(F)cc2)cc1.Cl>>Nc1nccc2c1ccn2-c1ccc(NC(=O)CC(=O)Nc2ccc(F)cc2)cc1",
        "output": "885"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)c1ccc(N2CCCCC2)cc1.CCCCCC.CCO.CCOC(=O)C(=O)OCC.CCOC(C)=O.[Na]>>CCOC(=O)C(=O)CC(=O)c1ccc(N2CCCCC2)cc1",
        "output": "526"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1C[C@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1COCc1cc(F)c(F)cc1F.ClCCl.O=C(O)C(F)(F)F>>Fc1cc(F)c(COC[C@@H]2C[C@@H](SC(c3ccccc3)(c3ccccc3)c3ccccc3)CN2)cc1F",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCC(C(=O)OC)c1c(CC)nc(N2CCCCC2)nc1-c1ccc(C)cc1.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(CC)nc(N2CCCCC2)nc1-c1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1c(C)cc(Cl)nc1C.OB(O)c1cccc(C(F)(F)F)c1>>CCOC(=O)c1c(C)cc(-c2cccc(C(F)(F)F)c2)nc1C",
        "output": "865"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc2c(N3CCN(C(=O)OC(C)(C)C)CC3)ccc(Cl)c2n1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc2c(N3CCNCC3)ccc(Cl)c2n1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCC(O)C=CC1CCC(CCCCCCCC(=O)OC)O1.CO.O=C([O-])[O-].[K+].[K+]>>CCCCCC(O)C=CC1CCC(CCCCCCCC(=O)O)O1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.Nc1ncnc2c1c(I)cn2[C@H]1CC[C@@H](N)CC1>>CC(=O)N[C@H]1CC[C@@H](n2cc(I)c3c(N)ncnc32)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Nc1scc(Br)c1-c1ncn[nH]1.O=C(O)CN1C(=O)CCc2cnccc21>>O=C(CN1C(=O)CCc2cnccc21)Nc1scc(Br)c1-c1ncn[nH]1",
        "output": "882"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)Nc1ccn(CCC(F)Cn2cc(C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)c(=O)c1F.ClCCl.O=C(O)C(F)(F)F>>Nc1ccn(CCC(F)Cn2cc(C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)c(=O)c1F",
        "output": "782"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.CS(=O)(=O)c1ccc(Br)nc1.O.O=C(OCc1ccccc1)N1CCC([C@H]2C[C@H]2CCO)CC1.[H-].[Na+]>>CS(=O)(=O)c1ccc(OCC[C@@H]2C[C@@H]2C2CCN(C(=O)OCc3ccccc3)CC2)nc1",
        "output": "551"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1CCC(N)N1.Nc1c(F)c(F)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1>>CC1CCC(N)N1c1c(F)c(N)c2c(=O)c(C(=O)O)cn(C3CC3)c2c1F",
        "output": "676"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1csc2nc([C@H](C)[NH3+])c(Br)c(=O)n12.O.O=C([O-])O.O=C([O-])[C@@H](O)c1ccccc1.[Na+]>>Cc1csc2nc([C@H](C)NC(=O)OC(C)(C)C)c(Br)c(=O)n12",
        "output": "631"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Oc1cccc2c1c1ccccc1n2S(=O)(=O)c1ccccc1.CO.[Na+].[OH-]>>O=S(=O)(c1ccccc1)n1c2ccccc2c2c(O)cccc21",
        "output": "22"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)NC1CCNCC1.CCN(CC)CC.ClCCCBr>>CC(=O)NC1CCN(CCCCl)CC1",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.COc1ccc(NCCCN)cc1Cl.Cl.O.O=C(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.On1nnc2ccccc21>>COc1ccc(NCCCNC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1Cl",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.ClCCCl.ClCCl.O=C(O)c1cc([N+](=O)[O-])cc(C(F)(F)F)c1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCN(C(=O)c2cc([N+](=O)[O-])cc(C(F)(F)F)c2)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCBr.CN(C)C=O.O=C([O-])[O-].Sc1ccc2ccccc2c1.[K+].[K+]>>CCSc1ccc2ccccc2c1",
        "output": "124"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.CCOC(C)=O.CN(C)C=O.N.O=C(O)c1cn(C2CC2)c2cc(F)c(F)cc2c1=O>>NC(=O)c1cn(C2CC2)c2cc(F)c(F)cc2c1=O",
        "output": "704"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClC(Cl)Cl.O=C(NCCCCNCc1ccc(CN2C(=O)c3ccccc3C2=O)cc1)OCc1ccccc1>>CC(C)(C)OC(=O)N(CCCCNC(=O)OCc1ccccc1)Cc1ccc(CN2C(=O)c3ccccc3C2=O)cc1",
        "output": "867"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(C)=O.C[S-].O.O=C1c2ccccc2C(=O)N1CCCBr.[Na+]>>CSCCCN1C(=O)c2ccccc2C1=O",
        "output": "185"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC1(C)CCC(=O)c2ccccc21.CCO.CCOC(C)=O.Cl.NO.[Na+]>>CC1(C)CCC(=NO)c2ccccc21",
        "output": "212"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)C(=O)C(CCCCOc1cc(Cl)ccc1F)n1cncn1.CCCC[N+](CCCC)(CCCC)CCCC.ClCCl.Cl[Ti](Cl)(Cl)Cl.[BH4-].[Cl-].[NH4+]>>CC(C)(C)C(O)C(CCCCOc1cc(Cl)ccc1F)n1cncn1",
        "output": "91"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(Nc2nc(Cl)ncc2F)c(NS(C)(=O)=O)c1.COc1ccc(OC)c(N)c1>>COc1ccc(Nc2nc(Nc3cc(OC)ccc3OC)ncc2F)c(NS(C)(=O)=O)c1",
        "output": "808"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Fc1cccc(C(F)(F)F)c1CBr.O=C([O-])[O-].O=[N+]([O-])c1cn[nH]c1.[K+].[K+]>>O=[N+]([O-])c1cnn(Cc2c(F)cccc2C(F)(F)F)c1",
        "output": "635"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.COC(=O)c1sccc1S(=O)(=O)N=C=O.COc1cc(C)nc(N)n1>>COC(=O)c1sccc1S(=O)(=O)NC(=O)Nc1nc(C)cc(OC)n1",
        "output": "566"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCN(c2nc(-c3cccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)c(-c3ccnc(Cl)n3)s2)CC1.CO.Cl.ClCCl>>O=S(=O)(Nc1cccc(-c2nc(N3CCNCC3)sc2-c2ccnc(Cl)n2)c1F)c1cc(F)ccc1F",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC.CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1.O.O.[Li+].[Na+].[OH-].[OH-]>>Clc1ccc2c(c1)CCc1cccnc1C2=C1CCNCC1",
        "output": "283"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CI.O=c1cc(OCc2ccc(F)cc2)ccn1-c1ccc2nc(C3CC3)c(CO)n2c1.[H-].[Na+]>>COCc1c(C2CC2)nc2ccc(-n3ccc(OCc4ccc(F)cc4)cc3=O)cn12",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br.COc1cc2c(cc1OC)C(=O)CCC2.O>>O=C1CCCc2cc(O)c(O)cc21",
        "output": "19"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC1Cc2ccc(C3CCNCC3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1.CCN(C(C)C)C(C)C.CO.Cl.O=C(Cl)CC1CCCC1>>CC1Cc2ccc(C3CCN(C(=O)CC4CCCC4)CC3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1",
        "output": "125"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)/C=C/c1cc(=O)n(CCN2CCC(NCc3ccc4c(c3)OCCO4)CC2)c2cc(OC)ccc12.O.[Na+].[OH-]>>COc1ccc2c(/C=C/C(=O)O)cc(=O)n(CCN3CCC(NCc4ccc5c(c4)OCCO5)CC3)c2c1",
        "output": "122"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1noc(C)c1-c1ccc2c(c1)C(C)NCC2.O=C(O)c1cc2ncc(Br)cn2n1>>Cc1noc(C)c1-c1ccc2c(c1)C(C)N(C(=O)c1cc3ncc(Br)cn3n1)CC2",
        "output": "952"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.CNc1ncc(-c2nc(N3CCOCC3)c3nc(Cl)n(CC4CC4)c3n2)cn1.CO.CS(C)=O.ClCCl>>CNc1ncc(-c2nc(N3CCOCC3)c3nc(N4CCOCC4)n(CC4CC4)c3n2)cn1",
        "output": "214"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN1CCNCC1.Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Oc1ccc2nc(NC(=O)CCl)sc2n1.O=C([O-])O.[Na+]>>CCN1CCN(CC(=O)Nc2nc3ccc(Oc4cc(NC(=O)c5cccc(C(C)(C)C#N)c5)ccc4C)nc3s2)CC1",
        "output": "340"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1NCCn2nncc21.O=C(O)c1cc2ncc(Br)cn2n1>>CC1c2cnnn2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "663"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#C[C@@H]1CN(C(=O)OC(C)(C)C)[C@H](CO[Si](C)(C)C(C)(C)C)CO1.CC#N.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Nc1ncccc1Br.[Cu]I>>CC(C)(C)OC(=O)N1C[C@@H](C#Cc2cccnc2N)OC[C@H]1CO[Si](C)(C)C(C)(C)C",
        "output": "719"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)C(=O)C1(N2CCCC2=O)CCNCC1.Cc1ccccc1>>CN(C)C(=O)C1(N2CCCC2)CCNCC1",
        "output": "112"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccccc1-c1cccc2c1OC(CN=[N+]=[N-])C2.[Pd]>>COc1ccccc1-c1cccc2c1OC(CN)C2",
        "output": "89"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COCCOC.Cl.FC(F)(F)c1cccc2c(-c3cccc(Br)c3)c(Cc3ccccc3)cnc12.O.O=C(O)CCc1ccc(B(O)O)cc1.O=C([O-])[O-].[Na+].[Na+]>>O=C(O)CCc1ccc(-c2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)cc1",
        "output": "837"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.Nc1ccc2c(c1)NC(=O)C2.O=C=Nc1cccc([N+](=O)[O-])c1>>O=C1Cc2ccc(NC(=O)Nc3cccc([N+](=O)[O-])c3)cc2N1",
        "output": "473"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)N1CCc2sc3cc[nH]c3c2CC1.O.[K+].[OH-]>>c1cc2sc3c(c2[nH]1)CCNCC3",
        "output": "283"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.COc1cccc(S(=O)(=O)N(CC(=O)O)c2ccc(Cl)cc2)c1.ClCCl.On1nnc2ccccc21.c1ccc(C2CCCN2)cc1>>COc1cccc(S(=O)(=O)N(CC(=O)N2CCCC2c2ccccc2)c2ccc(Cl)cc2)c1",
        "output": "633"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OB(c2cc(F)c(O)c(Cl)c2)OC1(C)C.CN1CCCC(n2cc(Nc3c(C(=O)C4CC4)cnc4ccc(Br)cc34)cn2)C1>>CN1CCCC(n2cc(Nc3c(C(=O)C4CC4)cnc4ccc(-c5cc(F)c(O)c(Cl)c5)cc34)cn2)C1",
        "output": "933"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCC.CN(C)C=O.COc1ccc2c(c1)CCC2(C)C>>COc1cc2c(cc1C=O)C(C)(C)CC2",
        "output": "239"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCCO.COc1cccc2c(Cl)c(C#N)cnc12.Cc1ccc(N)cc1O.Cl.c1ccncc1>>COc1cccc2c(Nc3ccc(C)c(O)c3)c(C#N)cnc12",
        "output": "115"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COCc1nccc(N)c1Cl.Cc1ccccc1C.O=C(Cl)Cc1ccc(Oc2ccc(Cl)cc2)cc1>>COCc1nccc(NC(=O)Cc2ccc(Oc3ccc(Cl)cc3)cc2)c1Cl",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CNOC.Cc1cc(C#N)ccc1C(=O)O.Cl.Cl.O.O.On1nnc2ccccc21>>CON(C)C(=O)c1ccc(C#N)cc1C",
        "output": "828"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)S(=O)(=O)Oc1ccc(OCC2CO2)cc1.Cc1nc2cc(C3=NNC(=O)CC3)ccc2n1CCN>>Cc1nc2cc(C3=NNC(=O)CC3)ccc2n1CCNCC(O)COc1ccc(OS(=O)(=O)C(C)C)cc1",
        "output": "16"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)CC1(c2ccc(-c3ccc(-c4cnco4)cc3)s2)CCNCCS1(=O)=O.CCN(CC)CC.CN(C)C=O.Cl.ClC(Cl)Cl.O=C(Cl)OCC1c2ccccc2-c2ccccc21>>CC(C)(C)OC(=O)CC1(c2ccc(-c3ccc(-c4cnco4)cc3)s2)CCN(C(=O)OCC2c3ccccc3-c3ccccc32)CCS1(=O)=O",
        "output": "219"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(C)=O.Cc1cc(O)cc(C)c1OCc1ccccc1.ClCC1CO1.O=C([O-])[O-].[K+].[K+]>>Cc1cc(OCC2CO2)cc(C)c1OCc1ccccc1",
        "output": "15"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)Cc1ccc(-c2onc(-c3ccccc3)c2C(=O)NCCOc2ccc(Cl)cc2Cl)c(Cl)c1.Cl.ClCCl.O.[Li+].[OH-]>>O=C(O)Cc1ccc(-c2onc(-c3ccccc3)c2C(=O)NCCOc2ccc(Cl)cc2Cl)c(Cl)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC1(C(F)(F)F)CCC(CO)CC1.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>COC1(C(F)(F)F)CCC(C=O)CC1",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.N#Cc1cccc(CN2CC[C@H](N)C2=O)c1.O=S(=O)(Cl)c1ccc(-c2ccncc2)cc1>>N#Cc1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc(-c4ccncc4)cc3)C2=O)c1",
        "output": "596"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(C)C[C@H](O[C@H](c1ccccc1)c1ccc(C#C[Si](C)(C)C)cc1)C(=O)NCC#N.CO.[Na]>>C#Cc1ccc([C@H](O[C@@H](CC(C)C)C(=O)NCC#N)c2ccccc2)cc1",
        "output": "337"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1ccc(NC(=O)C(CC(CC)OC)n2cc(OC)c(-c3cc(Cl)ccc3C#N)cc2=O)cc1.CO.O.O=C([O-])[O-].[Cs+].[Cs+]>>CCC(CC(C(=O)Nc1ccc(C(=O)O)cc1)n1cc(OC)c(-c2cc(Cl)ccc2C#N)cc1=O)OC",
        "output": "5"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)OB(c2ccc(-c3nc4c(cnn4-c4cccc(C#N)c4)c(=O)n3-c3ccc(Cl)cc3)cc2)OC1(C)C.CN(C)C=O.Cl[Pd]Cl.Nc1ccc(Br)nc1.O.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>N#Cc1cccc(-n2ncc3c(=O)n(-c4ccc(Cl)cc4)c(-c4ccc(-c5ccc(N)cn5)cc4)nc32)c1",
        "output": "939"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CCCN.CCOC(C)=O.CN(C)C=O.CNC(=O)n1cc(Cl)c2cc(Oc3ccnc(NC(=O)Oc4ccccc4)c3)ccc21.O=C([O-])O.[Na+]>>CCN(CC)CCCNC(=O)Nc1cc(Oc2ccc3c(c2)c(Cl)cn3C(=O)NC)ccn1",
        "output": "488"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=[N+]([O-])c1cc(F)ccc1OCCCCl.c1cc2c3c(c1)[C@@H]1CNCC[C@@H]1N3CCSC2>>O=[N+]([O-])c1cc(F)ccc1OCCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCSC3",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1sc(-c2ccc(C(F)(F)F)cc2)nc1CCN=[N+]=[N-].[Pd]>>Cc1sc(-c2ccc(C(F)(F)F)cc2)nc1CCN",
        "output": "89"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.Cc1ccc(N)cc1B1OC(C)(C)C(C)(C)O1.Cc1nnc(-c2ccc(Br)cn2)o1.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>Cc1nnc(-c2ccc(-c3cc(N)ccc3C)cn2)o1",
        "output": "938"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.NC(=O)CC1C2CCC1CC2.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCCC1C2CCC1CC2",
        "output": "112"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.COc1c(C)cnc(CO)c1C.ClCCl.O=[Mn]=O>>COc1c(C)cnc(C=O)c1C",
        "output": "263"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCCBr.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(O)c(Cl)c1.[K+].[K+]>>O=[N+]([O-])c1ccc(OCCBr)c(Cl)c1",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCC(O)(c2ccccc2)CC1.CS(C)=O.O.O=[N+]([O-])c1ccccc1F.[H-].[Na+]>>CN1CCC(Oc2ccccc2[N+](=O)[O-])(c2ccccc2)CC1",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=O.CC(=O)O.CCOC(=O)c1ccc2c(c1)nc1n2CCNC1.CO.[BH3-]C#N.[Na+]>>CCOC(=O)c1ccc2c(c1)nc1n2CCN(C)C1",
        "output": "217"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CON(C)C(=O)C(CC(=O)OC(C)(C)C)NS(=O)(=O)c1ccc([N+](=O)[O-])cc1OCCc1cccc2ccccc12.[Ni]>>CON(C)C(=O)C(CC(=O)OC(C)(C)C)NS(=O)(=O)c1ccc(N)cc1OCCc1cccc2ccccc12",
        "output": "401"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=[N+]([O-])c1cnc2nc(OCCN3CCOCC3)nc(N3CCOCC3)c2c1.[Pd]>>Nc1cnc2nc(OCCN3CCOCC3)nc(N3CCOCC3)c2c1",
        "output": "269"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCCC(CO)C1.CC(C)OC(=O)N=NC(=O)OC(C)C.O=C1NC(=O)c2ccccc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCCC(CN2C(=O)c3ccccc3C2=O)C1",
        "output": "420"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O=C(O)c1cccc([N+](=O)[O-])c1C1CC1.[H][H].[Pt]>>Nc1cccc(C(=O)O)c1C1CC1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.Cc1ccc2[nH]c(C(=O)O)c(Sc3ccc(Cl)cc3)c2c1.Cc1ccc2c(Sc3cc(Cl)cc(Cl)c3)c(CCC(N)=O)[nH]c2c1.O=C(Cl)C(=O)Cl.OCc1ccccc1.c1ccncc1>>Cc1ccc2[nH]c(C(=O)OCc3ccccc3)c(Sc3ccc(Cl)cc3)c2c1",
        "output": "331"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(O)c(C(=O)[O-])c1.Cc1ccccc1C.[Na+].[Na+].[OH-]>>COc1ccc(O)c(C(=O)O)c1",
        "output": "151"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.ClC(Cl)Cl.Nc1ccc(C=CC(=O)O)cc1.O=S(=O)(O)O>>COC(=O)C=Cc1ccc(N)cc1",
        "output": "174"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Cl.NC1CCN(CCCC(=O)c2ccccc2)CC1.O=S(=O)(Cl)c1ccc(Cl)cc1>>O=C(CCCN1CCC(NS(=O)(=O)c2ccc(Cl)cc2)CC1)c1ccccc1",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1cn(CC(=O)N2C[C@](C)(F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccc(OCc3ccccc3)cc12.CSc1ccccc1.O=C(O)C(F)(F)F>>CC(=O)c1cn(CC(=O)N2C[C@](C)(F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccc(O)cc12",
        "output": "23"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Cl.O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)NC1CCNCC1>>CC(=O)N1CCC(NC(=O)NCc2cn(-c3ccccc3)c3cc(Cl)ccc3c2=O)CC1",
        "output": "125"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)N.ClC(Cl)Cl.O=C([O-])O.O=Cc1ccnc(Br)c1.[Na+].[Na+]>>CC(C)NCc1ccnc(Br)c1",
        "output": "468"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(C2=NOC(c3ccccc3)C2)c(=O)n(C)n1.O.[Li+].[OH-]>>Cn1nc(C(=O)O)cc(C2=NOC(c3ccccc3)C2)c1=O",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(N)C(=O)OCC(C)C.O=C(O)Cc1cccc(F)c1>>CCC(NC(=O)Cc1cccc(F)c1)C(=O)OCC(C)C",
        "output": "107"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.CCOC(C)=O.COC(=O)Cc1ccc(O)cc1.O.OCCn1ccnc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)Cc1ccc(OCCn2ccnc2)cc1",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCl.Clc1ccc(CCN2CCNCC2)cc1.O=C(Cl)c1ccc(Cl)cc1>>O=C(c1ccc(Cl)cc1)N1CCN(CCc2ccc(Cl)cc2)CC1",
        "output": "201"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N1CCc2ccc(N(CCCN)C(=O)/C=C/c3ccccc3)cc21.CO.O=Cc1ccccc1.[BH4-].[Na+]>>CC(=O)N1CCc2ccc(N(CCCNCc3ccccc3)C(=O)/C=C/c3ccccc3)cc21",
        "output": "468"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CC(C)(COS(C)(=O)=O)[N+](=O)[O-].Cn1ncc(Cl)c1-c1cc(NC(=O)c2cccc(C(F)(F)F)c2)ccc1O.O.O=C([O-])[O-].[Cs+].[Cs+]>>Cn1ncc(Cl)c1-c1cc(NC(=O)c2cccc(C(F)(F)F)c2)ccc1OCC(C)(C)[N+](=O)[O-]",
        "output": "702"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COC(=O)c1cc(-c2nc(-c3ccc(F)c(Cl)c3)cs2)ccc1-c1ccccc1[N+](=O)[O-].O.[Na+].[OH-]>>O=C(O)c1cc(-c2nc(-c3ccc(F)c(Cl)c3)cs2)ccc1-c1ccccc1[N+](=O)[O-]",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCOC(=O)c1c(C)nc(NCCCc2cccc(O)c2)nc1CC.O.O.[Li]O>>CCc1nc(NCCCc2cccc(O)c2)nc(C)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=C(O)c1cccc2c1OCCC2.O=S(=O)(O)Cl>>O=C(O)c1cc(S(=O)(=O)Cl)cc2c1OCCC2",
        "output": "182"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(C)=O.CCOCC.Cl.O=C1C=CC(C2CC2)(C2CC2)C1.[H-]>>OC1C=CC(C2CC2)(C2CC2)C1",
        "output": "288"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)/C=C/c1cc[nH]c1.O.O=S(=O)(Cl)c1cccc(Br)c1.[H-].[Na+]>>CC(C)(C)OC(=O)/C=C/c1ccn(S(=O)(=O)c2cccc(Br)c2)c1",
        "output": "648"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)CC(NC(=O)[C@@H]1CCCN(C(=O)CCC2CCN(C(=O)OC(C)(C)C)CC2)C1)c1cncc(-c2ccccc2O)c1.FCCI.O.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)CC(NC(=O)[C@@H]1CCCN(C(=O)CCC2CCN(C(=O)OC(C)(C)C)CC2)C1)c1cncc(-c2ccccc2OCCF)c1",
        "output": "198"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC(O)(c1cn(Cc2ccn3c(-c4ccc(F)cc4)c(C(=O)O)cc3c2)nn1)C(F)(F)F.CCN>>CCNC(=O)c1cc2cc(Cn3cc(C(O)(CC)C(F)(F)F)nn3)ccn2c1-c1ccc(F)cc1",
        "output": "674"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNC(=O)C(CC(=O)O)CC(C)C.ClCCCl.ClCCl.Oc1c(F)c(F)c(F)c(F)c1F>>CNC(=O)C(CC(=O)Oc1c(F)c(F)c(F)c(F)c1F)CC(C)C",
        "output": "108"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)CCC(=O)c1cccc(OCc2c(C)cccc2C)c1.Cl.[Na+].[OH-]>>Cc1cccc(C)c1COc1cccc(C(=O)CCC(=O)O)c1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCOC(=O)Nc1ccc([N+](=O)[O-])cc1Br.CCO.Cl.O=C([O-])O.[Fe].[Na+]>>CCCOC(=O)Nc1ccc(N)cc1Br",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN(c1cc2c(cn1)ncn2C)c1ccc(C2CNC2)cc1F.CS(=O)(=O)Cl.ClCCl>>CN(c1cc2c(cn1)ncn2C)c1ccc(C2CN(S(C)(=O)=O)C2)cc1F",
        "output": "584"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)OC(C)C.COC(=O)CCOc1cc(COC2CN(C(=O)OCc3ccccc3)CCC2c2ccc(OCCCOCc3ccccc3OC)cc2)ccc1C.CS(C)=O.O=P([O-])([O-])[O-]>>COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OCc3ccccc3)CC2OCc2ccc(C)c(OCCC(=O)O)c2)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1ccc2nc(C(C)(C)C)cn2c1.NCCN>>CC(C)(C)c1cn2cc(C(=O)NCCN)ccc2n1",
        "output": "862"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CCCN1CCC(Cc2ccc(Cl)cc2)CC1.CCCCN.Nc1ccc(I)cc1F.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Nc1ccc(C#CCCN2CCC(Cc3ccc(Cl)cc3)CC2)cc1F",
        "output": "664"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1ccc2nc(Cl)cc(F)c2c1.ClCCl>>Oc1ccc2nc(Cl)cc(F)c2c1",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1O>>COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC(C)=O",
        "output": "126"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cl.ClCCl.F[P-](F)(F)(F)(F)F.NC1CCOCC1.O=C(O)COc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3ccccc3n2)c1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>O=C(COc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3ccccc3n2)c1)NC1CCOCC1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)CCc1ccc(NCc2ccc(C)c(-c3c(C)cc(OCC4(O)CCS(=O)(=O)CC4)cc3C)c2)cc1F.CO.Cl.O.[Cl-].[Na+].[Na+].[OH-]>>Cc1ccc(CNc2ccc(CCC(=O)O)c(F)c2)cc1-c1c(C)cc(OCC2(O)CCS(=O)(=O)CC2)cc1C",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)I.CCOC(=O)CCCCCCN(c1ccccn1)c1cc(O)ccn1.CCOC(C)=O.CN(C)C=O.O.O=C([O-])[O-].[Cl-].[K+].[K+].[Na+]>>CCOC(=O)CCCCCCN(c1ccccn1)c1cc(OC(C)C)ccn1",
        "output": "318"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CCOC(=O)Cc1c(Cl)nc(N)nc1Cl.NCc1nc2ccccc2o1>>CCOC(=O)Cc1c(Cl)nc(N)nc1NCc1nc2ccccc2o1",
        "output": "166"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc(N)ccn1.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(Cl)cc1F>>COc1cc(NC(=O)c2ccc(Cl)cc2F)ccn1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCc1ccccc1F.O=S(=O)(O)Cl>>CCc1cc(S(=O)(=O)Cl)ccc1F",
        "output": "357"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCN(c1cc(Cl)cc(C(=O)OC)c1C)C1CCNCC1.COCCBr.O.O=C([O-])[O-].[K+].[K+]>>CCN(c1cc(Cl)cc(C(=O)OC)c1C)C1CCN(CCOC)CC1",
        "output": "73"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CCN(CC)c1ccc(C=O)c(O)c1.CN(C)C=O.COc1ccc(CCl)cc1.O=C([O-])[O-].[I-].[K+].[K+]>>CCN(CC)c1ccc(C=O)c(OCc2ccc(OC)cc2)c1",
        "output": "49"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.CC(C)(C)[O-].CNc1cc(Cl)ccc1[N+](=O)[O-].Cc1cc(O)cc(C)c1[N+](=O)[O-].Cl.[K+]>>CNc1cc(Oc2cc(C)c([N+](=O)[O-])c(C)c2)ccc1[N+](=O)[O-]",
        "output": "299"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CN1C(=O)C2(N=C1N)c1cc(Br)ccc1OC1CC(O[Si](C)(C)C(C)(C)C)CCC12.Cl>>CN1C(=O)C2(N=C1N)c1cc(Br)ccc1OC1CC(O)CCC12",
        "output": "708"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)n1cc(NC(=O)NC(C(N)=O)C(=O)c2c[nH]c3ccccc23)c2ccccc21.CCOCC.CN(C)C=O.O=C([O-])[O-].O=C1c2ccccc2C(=O)N1CCCBr.[K+].[K+]>>CCOC(=O)n1cc(NC(=O)NC(C(N)=O)C(=O)c2cn(CCCN3C(=O)c4ccccc4C3=O)c3ccccc23)c2ccccc21",
        "output": "470"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.COC(=O)c1cc(Cl)nc(Cl)n1.COc1ccc(CCN)cc1.O>>COC(=O)c1cc(NCCc2ccc(OC)cc2)nc(Cl)n1",
        "output": "166"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCC[Sn](Cl)(CCCC)CCCC.CN(C)C=O.Cl.N#Cc1ccc(-c2c(C#N)c(-c3ccc(O)cc3F)nc3[nH]ncc23)cc1.[N-]=[N+]=[N-].[Na+]>>N#Cc1c(-c2ccc(O)cc2F)nc2[nH]ncc2c1-c1ccc(-c2nn[nH]n2)cc1",
        "output": "390"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Clc1nccn2ccnc12.O.O=C1CCC(=O)N1Br>>Clc1nccn2c(Br)cnc12",
        "output": "665"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cccc(B(O)O)c1.O=Cc1c[nH]c2ccc(Br)cc12>>Cc1cccc(-c2ccc3[nH]cc(C=O)c3c2)c1",
        "output": "837"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC1(SCC(=O)O)CCCO1.O>>CC1(SCCO)CCCO1",
        "output": "231"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCC(=O)Cl.ClCCl.Nc1n[nH]c2ncnc(Nc3cccc(Cl)c3)c12.c1ccncc1>>CCCCCCCC(=O)Nc1n[nH]c2ncnc(Nc3cccc(Cl)c3)c12",
        "output": "527"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCOc1nc(N)c2ncn(Cc3ccc(Cl)nc3)c2n1.CO.[Na]>>CCCCOc1nc(N)c2ncn(Cc3ccc(OC)nc3)c2n1",
        "output": "433"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1c(C=O)[nH]c2c1C(=O)N(CCN1CCCCC1)CCC2.O=C1Cc2cc(F)c(NCc3ccc(F)cc3)cc2N1>>Cc1c(C=C2C(=O)Nc3cc(NCc4ccc(F)cc4)c(F)cc32)[nH]c2c1C(=O)N(CCN1CCCCC1)CCC2",
        "output": "440"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1c[nH]cn1.FC(F)(F)c1ccc(-c2cc(C(F)(F)F)nc(Cl)n2)cc1>>FC(F)(F)c1ccc(-c2cc(C(F)(F)F)nc(-n3cnc(Br)c3)n2)cc1",
        "output": "788"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.COc1cc(C(C)O)ccc1F.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl>>COc1cc(C(C)=O)ccc1F",
        "output": "32"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Cl.O.O=C(O)C1CCC(C(F)(F)F)CC1>>COC(=O)C1CCC(C(F)(F)F)CC1",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)COc1ccc2cc(CNC(=O)c3cnn(-c4ccc(Cl)cc4)c3C(F)(F)F)ccc2c1Br.O.[Na+].[OH-]>>O=C(O)COc1ccc2cc(CNC(=O)c3cnn(-c4ccc(Cl)cc4)c3C(F)(F)F)ccc2c1Br",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)C1CCN(Cc2cc(Oc3ccc4c(ccn4C(=O)Nc4ccc(F)c(C(F)(F)F)c4)c3)ncn2)CC1.O.[Li+].[OH-]>>O=C(O)C1CCN(Cc2cc(Oc3ccc4c(ccn4C(=O)Nc4ccc(F)c(C(F)(F)F)c4)c3)ncn2)CC1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=CBr)c1ccc(F)cc1F.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>C/C(=C\\n1c2c(c3cc(C)ccc31)CN(C)CC2)c1ccc(F)cc1F",
        "output": "987"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)CCCOc1ccccc1CC(=O)O.ClCCl.O[C@H]1CCC(c2ccccc2)(c2ccccc2)[C@@H]2CNC[C@H]12.On1nnc2ccccc21>>CN(C)CCCOc1ccccc1CC(=O)N1C[C@@H]2[C@@H](O)CCC(c3ccccc3)(c3ccccc3)[C@@H]2C1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.C1COCCO1.CCOC(=O)N=NC(=O)OCC.CN(C)CCO.CN1CCN(C(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)ccc(-c4cccc(O)c4F)c23)CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN(C)CCOc1cccc(-c2ccc(C(N)=O)c3[nH]c4cc(C(=O)N5CCN(C)CC5)ccc4c23)c1F",
        "output": "478"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)(C)[Si](C)(C)Cl.O.OCCBr.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCBr",
        "output": "193"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCP(CCCC)CCCC.COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(-c5c(C)cc(O)cc5C)ccc(F)c43)ccc21.CSCCO.Cc1ccccc1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(-c5c(C)cc(OCCSC)cc5C)ccc(F)c43)ccc21",
        "output": "550"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.COC(=O)CCC1(C)CCc2cc(O)c3c(c2O1)C1CCC3C1.COCCl.ClCCl.O.[Cl-].[Na+]>>COCOc1cc2c(c3c1C1CCC3C1)OC(C)(CCC(=O)OC)CC2",
        "output": "375"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Nc1ccc(F)c(F)c1.O=C(O)Cc1ccccc1Br>>O=C(O)Cc1ccccc1Nc1ccc(F)c(F)c1",
        "output": "405"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CNC(=O)c1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1.O.[Na+].[OH-]>>CNCc1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1",
        "output": "215"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1CCOc1ccc(-c2ccccc2F)nc1>>NCCOc1ccc(-c2ccccc2F)nc1",
        "output": "242"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C(=O)Cc1ccc(F)cc1)C1CNCC1c1ccc(Cl)c(Cl)c1.Cc1cc(C(=O)O)cnn1>>Cc1cc(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)C(N(C)C(=O)Cc3ccc(F)cc3)C2)cnn1",
        "output": "256"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)N1CCN(c2cccc(Nc3ccc(C)cc3[N+](=O)[O-])c2)CC1.[H][H].[Pd]>>CC(=O)N1CCN(c2cccc(Nc3ccc(C)cc3N)c2)CC1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(c1ccc(Cl)nn1)C1CNC1.F[P-](F)(F)(F)(F)F.O=Cc1ccc(F)c(C(=O)O)c1>>CN(c1ccc(Cl)nn1)C1CN(C(=O)c2cc(C=O)ccc2F)C1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.ClCCl.NCCO.O=C(Cl)OCc1ccccc1>>O=C(NCCO)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(C(=O)O)cn1.Nc1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1>>Cc1ccc(C(=O)Nc2cnc(OCC(F)(F)F)c(-c3ccc(Cl)cc3)c2)cn1",
        "output": "863"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCCCC1.CC(Cl)c1ccc(C2CCCCC2)c(Cl)c1.CCOC(C)=O>>CC(Cl)c1ccc(C2CCCCC2)cc1",
        "output": "253"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)NC(C)C.ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1cccc2[nH]c3ccccc3c12>>O=S(=O)(Oc1cccc2[nH]c3ccccc3c12)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.Cc1c(CC(=O)O)c2cccnc2n1Cc1ccc([N+](=O)[O-])cc1.[Na+].[OH-]>>Cc1c(CC(=O)O)c2cccnc2n1Cc1ccc(N)cc1",
        "output": "507"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC(C)(c1cccc(Br)c1)c1cc[nH]n1.Cl>>CC(N)(c1cccc(Br)c1)c1cc[nH]n1",
        "output": "793"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.Cc1c(Nc2ccc(I)cc2F)c(N)c2n(c1=O)CCO2.O=S(=O)(Cl)C1CC1.c1ccncc1>>Cc1c(Nc2ccc(I)cc2F)c(NS(=O)(=O)C2CC2)c2n(c1=O)CCO2",
        "output": "812"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)c1ccc(/C=C/c2ccc(OC(F)(F)F)cc2)cc1Nc1ccc(F)cc1.O=C(O)C(F)(F)F>>O=C(O)c1ccc(/C=C/c2ccc(OC(F)(F)F)cc2)cc1Nc1ccc(F)cc1",
        "output": "752"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccccc3C=O)n(CCNC(=O)OC(C)(C)C)c2c1.Cl.[H-]>>COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccccc3CO)n(CCNC(=O)OC(C)(C)C)c2c1",
        "output": "356"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCC(c1ccc(O)cc1N1CCCCC1)C(C(N)=O)c1ccc(C(=O)OCC)cc1.CI.CN(C)C=O.[H-].[Na+]>>CCCC(c1ccc(OC)cc1N1CCCCC1)C(C(N)=O)c1ccc(C(=O)OCC)cc1",
        "output": "62"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)C(=O)c1c(C)n(Cc2cnc(Cl)cn2)c2ccc(OC)cc12.O.O.[Li+].[OH-]>>COc1ccc2c(c1)c(C(=O)C(=O)O)c(C)n2Cc1cnc(Cl)cn1",
        "output": "506"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COc1ccc(-c2c(C)c(C(=O)Nc3ccc(C(F)(F)F)cn3)nn2-c2ccc(Cl)cc2Cl)cc1.ClCCl>>Cc1c(C(=O)Nc2ccc(C(F)(F)F)cn2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc(Cc2cc(Br)ccc2Cl)cc1.ClCCl>>Oc1ccc(Cc2cc(Br)ccc2Cl)cc1",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Nc1cccc(Nc2cc(-c3ccccc3)ccc2C(=O)OC(C)(C)C)c1.O=C(O)C(F)(F)F>>CC(=O)Nc1cccc(Nc2cc(-c3ccccc3)ccc2C(=O)O)c1",
        "output": "752"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1ccn(-c2ccccc2)c1.Cl.[Na+].[OH-]>>O=C(O)c1ccn(-c2ccccc2)c1",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.COC(=O)c1nc(Br)cc(N)c1OCc1ccccc1>>COC(=O)c1nc(Br)cc(NC(C)=O)c1OCc1ccccc1",
        "output": "6"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(C)=O.CN1CCNCC1.Fc1ccc(Br)cn1>>CN1CCN(c2ccc(Br)cn2)CC1",
        "output": "756"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cnn(C)c1Oc1ccccc1.CO.O.[Li+].[OH-]>>Cn1ncc(C(=O)O)c1Oc1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(CC(=O)Cl)cc1.Cc1ccc(N)cc1CCN1CCC(c2c[nH]c3c(Cl)cccc23)CC1>>COc1ccc(CC(=O)Nc2ccc(C)c(CCN3CCC(c4c[nH]c5c(Cl)cccc45)CC3)c2)cc1",
        "output": "9"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CCNC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cc(OC)c(NC(=O)Cn2c(=O)n(CC(=O)O)c(=O)c3ccccc32)cc1Cl.F[P-](F)(F)(F)(F)F.O>>COc1cc(OC)c(NC(=O)Cn2c(=O)n(CC(=O)N3CC[C@@H](NC(=O)OC(C)(C)C)C3)c(=O)c3ccccc32)cc1Cl",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc(-c2cccc(N)c2)cc1.F[P-](F)(F)(F)(F)F.O=C(O)c1cc2cccc(O)c2oc1=O>>COc1ccc(-c2cccc(NC(=O)c3cc4cccc(O)c4oc3=O)c2)cc1",
        "output": "799"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.Cc1cc(Oc2c(C(C)C)c(=O)[nH]c(=O)n2Cc2ccncc2)cc(C2OCCO2)c1.Cc1ccc(S(=O)(=O)O)cc1.O.O.O=C([O-])O.[Na+]>>Cc1cc(C=O)cc(Oc2c(C(C)C)c(=O)[nH]c(=O)n2Cc2ccncc2)c1",
        "output": "655"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCI.CN(C)C=O.COC(=O)c1ccc(=O)[nH]c1.O.[H-].[Na+]>>CCn1cc(C(=O)OC)ccc1=O",
        "output": "302"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)CCCBr.CCOCC.Nc1ccccc1-c1ccccc1>>CCOC(=O)CCCNc1ccccc1-c1ccccc1",
        "output": "273"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1oc2cccc(C#N)c2c1C.CO.[Li+].[OH-]>>Cc1c(C(=O)O)oc2cccc(C#N)c12",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.Clc1ccc(C2(c3ccc(Br)cc3)CCNCC2)cc1.O>>CC(C)(C)OC(=O)N1CCC(c2ccc(Cl)cc2)(c2ccc(Br)cc2)CC1",
        "output": "694"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc2nccc(Cl)c2cc1OC.Cc1ccc(Cn2cncc(-c3ccc(O)c(F)c3)c2=O)cc1C>>COc1cc2nccc(Oc3ccc(-c4cncn(Cc5ccc(C)c(C)c5)c4=O)cc3F)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O.OCC1(c2ccc(Br)cc2)CCC1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCC1(c2ccc(Br)cc2)CCC1",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cnn(-c2ccc(C3CC3)cn2)c1C.CO.O.[Na+].[OH-]>>Cc1c(C(=O)O)cnn1-c1ccc(C2CC2)cn1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCN(C(=O)OC(C)(C)C)c1ccc(C(=O)OC)cn1.O.O.[Li+].[OH-]>>CCN(C(=O)OC(C)(C)C)c1ccc(C(=O)O)cn1",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CN1CCOCC1.COc1ccc([C@H](O)CN)cc1Br.Cl.Cl.O=c1[nH]ccc(Cl)c1-c1nc2cc3cn[nH]c3cc2[nH]1>>COc1ccc([C@H](O)CNc2cc[nH]c(=O)c2-c2nc3cc4cn[nH]c4cc3[nH]2)cc1Br",
        "output": "78"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NCC(=O)NC(c1cccc(F)c1)c1cccc(F)c1.O=C(O)c1ccncc1>>O=C(CNC(=O)c1ccncc1)NC(c1cccc(F)c1)c1cccc(F)c1",
        "output": "718"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(-c2noc(-c3ccnc(Br)c3)n2)cc1.O=[N+]([O-])c1cc(-c2cc3ccc(O)cc3o2)ccn1>>Oc1ccc(-c2noc(-c3ccnc(Br)c3)n2)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#Cc1ccc(-c2ccc(Cl)cc2)cn1.Ic1ccc2nc(CN3CCCC3)ccc2c1>>Clc1ccc(-c2ccc(C#Cc3ccc4nc(CN5CCCC5)ccc4c3)nc2)cc1",
        "output": "664"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C(=O)Cl)CCCCC1.CCN(CC)CC.COc1ccccc1N1CCN(C[C@H](N)Cc2ccccn2)CC1.ClCCl>>COc1ccccc1N1CCN(C[C@@H](Cc2ccccn2)NC(=O)C2(C)CCCCC2)CC1",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCOC(=O)c1ccc(N)cc1.CC1(C)CCC(C)(C)c2cc(C(F)C(=O)O)ccc21>>C=CCOC(=O)c1ccc(NC(=O)C(F)c2ccc3c(c2)C(C)(C)CCC3(C)C)cc1",
        "output": "710"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Fc1cnc(Cl)nc1.O.O=C([O-])[O-].OC[C@H]1CC[C@H]2CNCCN2C1.[Na+].[Na+]>>OC[C@H]1CC[C@H]2CN(c3ncc(F)cn3)CCN2C1",
        "output": "36"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(Cc1ccccc1)C(=O)CCCOc1ccc(OCc2ccccc2)cc1.ClB(Cl)Cl.ClCCl>>CN(Cc1ccccc1)C(=O)CCCOc1ccc(O)cc1",
        "output": "23"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.COc1ccccc1S(=O)(=O)Oc1cc(C)cc(OCCO)c1.CS(C)=O.ClCCl>>COc1ccccc1S(=O)(=O)Oc1cc(C)cc(OCC=O)c1",
        "output": "142"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CC(C)(C)C(O)c1cc(C(=O)OC)ccc1-c1cc(OC)ccc1F.CI.CN(C)C=O.O.[H-].[Na+]>>C=CC(C)(C)C(OC)c1cc(C(=O)OC)ccc1-c1cc(OC)ccc1F",
        "output": "140"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CSC1(N)CN([Si](C)(C)C(C)(C)C)C1=O.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O=C(Cl)COc1ccccc1.c1ccncc1>>CSC1(NC(=O)COc2ccccc2)CN([Si](C)(C)C(C)(C)C)C1=O",
        "output": "159"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(=O)Cl.c1cc(-c2ccc(Oc3ccc4nc(CN5CCNCC5)ccc4c3)cc2)[nH]n1>>CCC(=O)N1CCN(Cc2ccc3cc(Oc4ccc(-c5ccn[nH]5)cc4)ccc3n2)CC1",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.ClCCl.Clc1nccc(CNC2CC2)n1.O>>CS(=O)(=O)N(Cc1ccnc(Cl)n1)C1CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCOc1ccc(C=O)cc1OC.CC(=O)[O-].CCO.CON.Cl.[Na+]>>C#CCOc1ccc(C=NOC)cc1OC",
        "output": "30"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1noc2ccc(C=O)cc12.O=C1CSC(=O)N1>>Nc1noc2ccc(C=C3SC(=O)NC3=O)cc12",
        "output": "761"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.CC1(C)CCc2ccc(O)cc21.ClC(Cl)(Cl)Cl>>CC1(C)CCc2cc(Br)c(O)cc21",
        "output": "98"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)[Si](OCC(C)(C)C(=O)O)(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)c1ccncc1.CNOC.Cl.ClCCl>>CON(C)C(=O)C(C)(C)CO[Si](C(C)C)(C(C)C)C(C)C",
        "output": "54"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)Nc1cc(N2CC3CCC(C2)O3)nc(-c2ccc([N+](=O)[O-])cc2)n1.CC(C)O.ClCCl.[Pd]>>CC(C)Nc1cc(N2CC3CCC(C2)O3)nc(-c2ccc(N)cc2)n1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OCCC(NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(OC(F)(F)F)cc1.CO.O=C([O-])[O-].[K+].[K+]>>O=C1CN(C(=O)NC(CCO)c2ccc(OC(F)(F)F)cc2)c2ncccc2N1",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.COC(=O)[C@H]1CC(=O)N(c2ccc(O)cc2)C1.O=P(c1ccccc1)(c1ccccc1)c1ccccc1.OCc1cccc(F)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)[C@H]1CC(=O)N(c2ccc(OCc3cccc(F)c3)cc2)C1",
        "output": "347"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(Cc2cc(C(=O)N[C@H]3CCOC[C@@H]3O)nc3ccccc23)cn1.C[Si](C)(C)I.ClCCl>>O=C(N[C@H]1CCOC[C@@H]1O)c1cc(Cc2ccc(O)nc2)c2ccccc2n1",
        "output": "408"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=[N+]=[N-].CC(=O)O.CCCCC[C@@H](/C=C/[C@H]1C(O)C=C[C@@H]1C/C=C\\CCCC(=O)O)OC(C)=O.CCOCC.NC(=O)NCN=O.[K+].[OH-]>>CCCCC[C@@H](/C=C/[C@H]1C(O)C=C[C@@H]1C/C=C\\CCCC(=O)OC)OC(C)=O",
        "output": "60"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "FC(F)(F)c1cc(-c2cccc(C3CCNCC3)n2)cc(C(F)(F)F)c1.O=C(O)Cn1cnc2cccnc21>>O=C(Cn1cnc2cccnc21)N1CCC(c2cccc(-c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.COCC(=O)Cl.COc1ccc(CCN)cc1OC1CCCC1>>COCC(=O)NCCc1ccc(OC)c(OC2CCCC2)c1",
        "output": "45"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1c(CCl)cccc1Oc1ccccc1Cl.CS(C)=O.[C-]#N.[K+]>>COc1c(CC#N)cccc1Oc1ccccc1Cl",
        "output": "38"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.C[Si](C)(C)CCOCn1ccc(-c2ccc3c(N)c(Cl)ccc3n2)n1.O=C(Cl)CCl.O=C([O-])[O-].[K+].[K+]>>C[Si](C)(C)CCOCn1ccc(-c2ccc3c(NC(=O)CCl)c(Cl)ccc3n2)n1",
        "output": "9"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)c1cccc(C(C)(C)C)c1O.O=C(Cl)C1CC1>>CC(C)(C)c1cc(C(=O)C2CC2)cc(C(C)(C)C)c1O",
        "output": "31"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cc1cccc(C)c1-c1ccc([N+](=O)[O-])cc1.[H][H].[Pd]>>Cc1cccc(C)c1-c1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CN(C)c1ccncc1.C[Si](C)(C)CCO.ClCCl.O=C(O)c1c(O)ccc2ccccc12>>C[Si](C)(C)CCOC(=O)c1c(O)ccc2ccccc12",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.COC(=O)Cc1ccc(O)cc1.Cc1noc(C)c1C(=O)CBr.O=C([O-])[O-].[K+].[K+]>>COC(=O)Cc1ccc(OCC(=O)c2c(C)noc2C)cc1",
        "output": "221"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COC(=O)c1ccc2[nH]c(=O)n(Cc3ccccc3)c(=O)c2c1.CS(C)=O.Cl.O>>O=C(O)c1ccc2[nH]c(=O)n(Cc3ccccc3)c(=O)c2c1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(=O)Nc1cccc(C2CCNCC2)c1.O=C(CCCCl)c1ccc(F)cc1>>CCC(=O)Nc1cccc(C2CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1",
        "output": "138"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C(=O)O)CC1.CCN(CC)CC.CCOC(=O)C1CCNCC1.ClCCCl.ClCCl.On1nnc2ccccc21>>CCOC(=O)C1CCN(C(=O)C2(C)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CN.COC(=O)C(C)NC(=O)c1cccnc1>>CNC(=O)C(C)NC(=O)c1cccnc1",
        "output": "392"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.COC(=O)c1cc(Cl)cc(OC2CCNCC2)c1C.Cl.[Na+]>>COC(=O)c1cc(Cl)cc(OC2CCN(C)CC2)c1C",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)c1ccncc1.ClCCl.Cn1ccnc1N1CCC(O)CC1.c1c[nH]cn1>>Cn1ccnc1N1CCC(O[Si](C)(C)C(C)(C)C)CC1",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C[O-].Cc1cc(Br)cc2c(Cl)c(-c3ccc(OC(F)(F)F)cc3)c(Cl)nc12.Cc1ccccc1.ClCCl.[Na+]>>COc1nc2c(C)cc(Br)cc2c(Cl)c1-c1ccc(OC(F)(F)F)cc1",
        "output": "433"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(C(=O)C[C@H](c2ccc(C3CN(S(N)(=O)=O)C3)cc2)c2ccccc2C)ccn1.Cl.NO.O=C([O-])O.[Na+]>>Cc1cc(/C(C[C@H](c2ccc(C3CN(S(N)(=O)=O)C3)cc2)c2ccccc2C)=N/O)ccn1",
        "output": "212"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)N[C@@H](C)COc1ccc(C(=O)O)cc1.Cl.Nc1ccc(O)cc1O>>CC(=O)N[C@@H](C)COc1ccc(C(=O)Nc2ccc(O)cc2O)cc1",
        "output": "50"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCN1.CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)nc1NCc1cccc(Cl)c1Cl.[K+].[K+]>>O=[N+]([O-])c1ccc(N2CCOCC2)nc1NCc1cccc(Cl)c1Cl",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=S(=O)(CCCNCCO)CCCC(F)(F)C(F)(F)F.Oc1cc(C2=C(CCCCCCBr)c3ccc(O)c(F)c3CCC2)ccc1F>>O=S(=O)(CCCN(CCO)CCCCCCC1=C(c2ccc(F)c(O)c2)CCCc2c1ccc(O)c2F)CCCC(F)(F)C(F)(F)F",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Fc1ccccc1CCl.O=Cc1ccc(O)cc1.[Na+].[OH-]>>O=Cc1ccc(OCc2ccccc2F)cc1",
        "output": "49"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cc1ccccc1C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)OCc3ccccc3)c2)CN(C(=O)C(C)(C)C)c2ccccc21.[C].[Pd]>>Cc1ccccc1C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)CN(C(=O)C(C)(C)C)c2ccccc21",
        "output": "290"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CCC(CC)C(NS(=O)(=O)c1ccc(Cl)s1)c1nccn1Cc1ccc(OC)cc1.ClCCl.O>>CCC(CC)C(NS(=O)(=O)c1ccc(Cl)s1)c1nccn1Cc1ccc(O)cc1",
        "output": "207"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)[O-].CC(=O)[O-].CN(C)C=O.COc1cccc(CN(C)c2cncc(Br)c2)c1.O.O=C([O-])O.OB(O)c1cccc(O)c1.[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cccc(CN(C)c2cncc(-c3cccc(O)c3)c2)c1",
        "output": "833"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCC.CCN(CC)CC.CCOC(C)=O.CCOP(=O)(C#N)OCC.CN(C)C=O.COc1cc(CN2CCNCC2)cc(OC)c1OC.Cl.Cl.O.O=C(O)c1ccc2[nH]ccc2c1>>COc1cc(CN2CCN(C(=O)c3ccc4[nH]ccc4c3)CC2)cc(OC)c1OC",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)C(CCCC1CCCCCC1)C(=O)O.CCOC(=O)CCCCC1CCCCCC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCCCC1CCCCCC1",
        "output": "225"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.CO.ClCCl.ClCCl.O=C1CCOCC1.O=[N+]([O-])c1ccc(N2CCNCC2)cc1.[BH3-]C#N.[Cl-].[Cl-].[Na+].[Zn+2]>>O=[N+]([O-])c1ccc(N2CCN(C3CCOCC3)CC2)cc1",
        "output": "187"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.COC(=O)c1cc(-c2ccc(OC)cc2)n[nH]c1=O>>COC(=O)c1cc(-c2ccc(OC)cc2)nn(Cc2ccccc2)c1=O",
        "output": "635"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1c(C)nn2c(OCc3c(F)cccc3F)cc(C3CC3)cc12.CO.C[Si](C)(C)[O-].[K+].[Na+].[OH-]>>Cc1nn2c(OCc3c(F)cccc3F)cc(C3CC3)cc2c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CNCCN1.CC(=O)N(C)C.CCN(C(C)C)C(C)C.Clc1ccc(I)cn1>>Ic1ccc(N2CCNCC2)nc1",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(Oc1ccccc1)C(=O)N1CCN(Cc2ccccc2)CC1.Cl.O=C(C1Cc2cc(F)ccc2O1)N1CCN(Cc2ccccc2)CC1>>CC(CN1CCN(Cc2ccccc2)CC1)Oc1ccccc1",
        "output": "112"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)/N=N/C(=O)OCC.CCOC(=O)C(Cc1ccc(O)cc1)OC.CCc1ccc(OC(C)CCO)c(C(=O)c2ccccc2)c1.Cc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)C(Cc1ccc(OCCC(C)Oc2ccc(CC)cc2C(=O)c2ccccc2)cc1)OC",
        "output": "478"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=C(C)COc1ccc2c(=O)c(C)c(-c3ccccc3)oc2c1C(C)=O.CCO.COc1cc(C=O)cc(OC)c1OC.O.[K+].[OH-]>>C=C(C)COc1ccc2c(=O)c(C)c(-c3ccccc3)oc2c1C(=O)C=Cc1cc(OC)c(OC)c(OC)c1",
        "output": "295"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.O=C(O)c1ccc(Br)cc1F.c1cc(N2CCNCC2)ccn1>>O=C(c1ccc(Br)cc1F)N1CCN(c2ccncc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.CC(=O)N(C)C.CCN(C(C)C)C(C)C.CCOC(C)=O.COc1cc(CNC(=O)c2nc3scc(COC[C@H]4CC[C@H](N)CC4)c3c(=O)[nH]2)ccc1F.ClCCl>>COc1cc(CNC(=O)c2nc3scc(COC[C@@H]4CC[C@@H](NC(C)=O)CC4)c3c(=O)[nH]2)ccc1F",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCc1ccc(C(=O)O)cc1N.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClCCl.Cn1cc(-c2ccc(C3CCNCC3)cc2)cn1.F[P-](F)(F)(F)(F)F.O=C([O-])[O-].[Na+].[Na+]>>CCc1ccc(C(=O)N2CCC(c3ccc(-c4cnn(C)c4)cc3)CC2)cc1N",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(CC)CC.COC(=O)C1CCN(C(=O)OC)C(c2cc(F)c(F)c(F)c2)C1.COC(C)(C)C.O.[Br-].[Li+]>>COC(=O)N1CCC(C(=O)O)CC1c1cc(F)c(F)c(F)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.ClCCl.Nc1ccc(C(=O)O)cc1F.c1ccc(CN2CCNCC2)cc1>>Nc1ccc(C(=O)N2CCN(Cc3ccccc3)CC2)cc1F",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCCC1c1ncc(-c2ccc3cc(Br)ccc3c2)[nH]1.COC(=O)NC(C(=O)N1C2CCC(C2)C1c1ncc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)[nH]1)C(C)C>>COC(=O)NC(C(=O)N1C2CCC(C2)C1c1ncc(-c2ccc(-c3ccc4cc(-c5cnc(C6CCCN6C(=O)OC(C)(C)C)[nH]5)ccc4c3)cc2)[nH]1)C(C)C",
        "output": "933"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O=C(O)CCc1cnoc1-c1cc(Cl)c(Cl)s1.O=S(=O)(O)O>>COC(=O)CCc1cnoc1-c1cc(Cl)c(Cl)s1",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCn1c(=O)c2nc(C(C)Cc3ccc(OCC(=O)OCC)cc3)[nH]c2n(CCC)c1=O.CCO.O.[K+].[OH-]>>CCCn1c(=O)c2nc(C(C)Cc3ccc(OCC(=O)O)cc3)[nH]c2n(CCC)c1=O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOP(=O)(C#N)OCC.Cl.ClCCl.O.O=C(O)COc1ccc2ccccc2c1.c1cc2c(o1)CCNC2>>O=C(COc1ccc2ccccc2c1)N1CCc2occc2C1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COC(=O)c1ccsc1-c1ccc([N+](=O)[O-])cc1.Cl.O.[Fe]>>COC(=O)c1ccsc1-c1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.ClCCl.NC1CC1.O=Cc1ccc(F)c2ccccc12.O=S(=O)([O-])[O-].[BH4-].[Mg+2].[Na+]>>Fc1ccc(CNC2CC2)c2ccccc12",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)COC(C)c1ccc(-n2ccc(C(C)c3ccc4c(c3)sc(=O)n4COCC[Si](C)(C)C)n2)nc1.[BH4-].[Li+]>>CC(OCCO)c1ccc(-n2ccc(C(C)c3ccc4c(c3)sc(=O)n4COCC[Si](C)(C)C)n2)nc1",
        "output": "225"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)CC(c1cccc(OCc2cnc(-c3cc(OC)ccc3F)c(CC(C)(C)C)c2)c1)C1CC1.Cl.[Na+].[OH-]>>COc1ccc(F)c(-c2ncc(COc3cccc(C(CC(=O)O)C4CC4)c3)cc2CC(C)(C)C)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Nc1ccc(Oc2ccnc(C(=O)NCC3CC3)c2)cc1.O=C=Nc1ccc(F)cc1>>O=C(Nc1ccc(F)cc1)Nc1ccc(Oc2ccnc(C(=O)NCC3CC3)c2)cc1",
        "output": "912"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.FC(F)(F)c1ccc(Cl)c(Cl)c1.Nc1cc(Cl)c(S)cc1F.O.O=C([O-])[O-].[K+].[K+]>>Nc1cc(Cl)c(Sc2ccc(C(F)(F)F)cc2Cl)cc1F",
        "output": "233"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C(=O)O)CCc2ncc(NC(=O)OCc3ccccc3)c(=O)n21.CCC1(C(=O)OC(C)(C)C)CCc2ncc(NC(=O)OCc3ccccc3)c(=O)n21>>CCC1(C(=O)O)CCc2ncc(NC(=O)OCc3ccccc3)c(=O)n21",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)CCn1ncc2cc(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)ccc21.CO.[Na+].[OH-]>>CC(C)Oc1ccc(-c2nc(-c3ccc4c(cnn4CCC(=O)O)c3)no2)cc1Cl",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1c(-c2cccnc2)[nH]c2ccccc12.Cl.N#Cc1ccc(CBr)cc1>>Cc1c(-c2cccnc2)n(Cc2ccc(C#N)cc2)c2ccccc12",
        "output": "528"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cc(C(C)(C)CC(C)(C)C)ccc1Oc1ccc(C(F)(F)F)cc1N.[Na+].[OH-]>>CC(C)(C)CC(C)(C)c1ccc(Oc2ccc(C(F)(F)F)cc2N)c(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cl[Sn](Cl)(Cl)Cl.N#Cc1ncc([N+](=O)[O-])cc1Cl.O=C([O-])O.[Na+]>>N#Cc1ncc(N)cc1Cl",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCN(C(C)C)C(C)C.Cl.O=C(Cl)C1CCCC1.O=C(N1CCC2(CCNC2)CC1)N1CCC[C@H](NC(=O)C23CC4CC(C2)C(O)C(C4)C3)C1>>O=C(C1CCCC1)N1CCC2(CCN(C(=O)N3CCC[C@H](NC(=O)C45CC6CC(C4)C(O)C(C6)C5)C3)CC2)C1",
        "output": "125"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=O.CNC1CCC(Oc2ncnc3sc4c(c23)[C@@H](C[C@@H](O)c2cc[nH]n2)CC4)CC1.CO.Cl.[BH3-]C#N.[Na+]>>CN(C)C1CCC(Oc2ncnc3sc4c(c23)[C@@H](C[C@@H](O)c2cc[nH]n2)CC4)CC1",
        "output": "217"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(Cl)nc(-c2ccccn2)n1.Nc1cccc([N+](=O)[O-])c1>>Cc1cc(Nc2cccc([N+](=O)[O-])c2)nc(-c2ccccn2)n1",
        "output": "161"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.Cc1ccccc1.ClCCl.Cl[Pd]Cl.O=c1c2cc(Br)c3ccccc3c2ncn1[C@H]1CCCC[C@@H]1O.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2cc3c(=O)n([C@H]4CCCC[C@@H]4O)cnc3c3ccccc23)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=Cc1ccc(N2CCC(CN3CCCC3)CC2)c(C(F)(F)F)c1.OCC1CCNCC1>>OCC1CCN(Cc2ccc(N3CCC(CN4CCCC4)CC3)c(C(F)(F)F)c2)CC1",
        "output": "567"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O.CCN(C(C)C)C(C)C.CC[C@H](C)[C@H](NC)[C@@H](CC(=O)OC(C)(C)C)OC.CC[n+]1ccccc1Br.ClCCl.F[B-](F)(F)F.[Cl-].[Na+]>>CC[C@H](C)[C@@H]([C@@H](CC(=O)OC(C)(C)C)OC)N(C)C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Nc1cc(C)c(F)cc1[N+](=O)[O-].CO.O.[K+].[OH-]>>Cc1cc(N)c([N+](=O)[O-])cc1F",
        "output": "66"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.COC[C@H](C)NCc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)nc1>>COC[C@H](C)N(Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)nc1)C(C)=O",
        "output": "369"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#C[C@H](CC(=O)O)c1ccc(O)cc1.CCO.O=S(=O)(O)O>>CC#C[C@H](CC(=O)OCC)c1ccc(O)cc1",
        "output": "47"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "B.C1CCOC1.C1CCOC1.CC1c2cc(Br)ccc2S(=O)(=O)N1CC(=O)N1CCOCC1>>CC1c2cc(Br)ccc2S(=O)(=O)N1CCN1CCOCC1",
        "output": "112"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN1CCC(N)CC1.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C.On1nnc2ccccc21>>COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.ClCCl.O=C1OC(Cc2ccccc2)CN1c1ccc(Br)cc1.[K+]>>CC1(C)OB(c2ccc(N3CC(Cc4ccccc4)OC3=O)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=C(OCc1ccccc1)N1CCC2(CCc3ccccc3O2)CC1.[H][H].[Pd]>>c1ccc2c(c1)CCC1(CCNCC1)O2",
        "output": "428"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCC(O)CCCC.C[N+](=O)[O-].Cc1ccc(I)c(S(=O)(=O)O)c1.O=S([O-])OO.[K+]>>CCCCC(=O)CCCC",
        "output": "87"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C1CCCc2ccc([N+](=O)[O-])cc21.[BH4-].[Na+]>>O=[N+]([O-])c1ccc2c(c1)C(O)CCC2",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C(=O)O)CC1.COCCN>>COCCNC(=O)[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.ClCC1CO1.O.O=[N+]([O-])c1cc(F)ccc1O.[Na+].[OH-]>>O=[N+]([O-])c1cc(F)ccc1OCC1CO1",
        "output": "15"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCCCCCCCCC[C@H](O)CC(=O)OC.OCC(Cl)(Cl)Cl>>CCCCCCCCCCCCC[C@H](O)CC(=O)OCC(Cl)(Cl)Cl",
        "output": "289"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C)C=O.O=C(O)CC(O)(CC(=O)O)C(=O)O.Oc1ccc2cc(Br)ccc2c1.[Li]CCCC>>O=Cc1ccc2cc(O)ccc2c1",
        "output": "638"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1CCCC(N=C=O)C1.CCN(C(C)C)C(C)C.Cl.Cl.ClCCCl.NCc1ccnc(-n2[nH]cc(-c3cccnc3)c2=O)c1>>CC1CCCC(NC(=O)NCc2ccnc(-n3[nH]cc(-c4cccnc4)c3=O)c2)C1",
        "output": "244"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCCBr.Cn1ccnc1Sc1ccc(Nc2ncnc3ccc(O)cc23)cc1F>>Cn1ccnc1Sc1ccc(Nc2ncnc3ccc(OCCBr)cc23)cc1F",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CCOC(C)=O.CC[C@H](N)c1nc2cccc(F)c2c(=O)n1-c1ccccc1.Cn1nnc(-c2c(N)ncnc2Cl)n1>>CC[C@H](Nc1ncnc(N)c1-c1nnn(C)n1)c1nc2cccc(F)c2c(=O)n1-c1ccccc1",
        "output": "110"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOC(=O)c1nn(CCO)c(CC)c1Sc1cc(Cl)cc(Cl)c1.CN(C)C=O.c1c[nH]cn1>>CCOC(=O)c1nn(CCO[Si](C)(C)C(C)(C)C)c(CC)c1Sc1cc(Cl)cc(Cl)c1",
        "output": "193"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)C(=O)CN1CCNCCN(CC(=O)C(C)(C)C)CCN(CC(=O)C(C)(C)C)CC1.CCN(CC)CC.CN(C)C=O.Cc1ccc(N=C=O)cc1>>Cc1ccc(NC(=O)N2CCN(CC(=O)C(C)(C)C)CCN(CC(=O)C(C)(C)C)CCN(CC(=O)C(C)(C)C)CC2)cc1",
        "output": "323"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)S[C@@H]1CO[C@H](CO)C1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CC(=O)S[C@@H]1CO[C@H](COS(=O)(=O)C(F)(F)F)C1",
        "output": "582"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)C1(c2ccc(CCl)cc2)CC1.Cl.Cl.Fc1ccc(N2CCNCC2)c(F)c1>>COC(=O)C1(c2ccc(CN3CCN(c4ccc(F)cc4F)CC3)cc2)CC1",
        "output": "156"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)c1cccc(C(C)C)c1N.CN(C)C=O.O.O=C1CCC(=O)N1Br>>CC(C)c1cc(Br)cc(C(C)C)c1N",
        "output": "4"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)[C@H](Cc1ccc(C(F)(F)F)cc1)C(=O)OC(C)(C)C.Cl.[Li+].[OH-]>>CC(C)(C)OC(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C[C@H](N)c1ccccc1.Clc1nccc(CCc2c[nH]c3ccccc23)n1>>C[C@H](Nc1nccc(CCc2c[nH]c3ccccc23)n1)c1ccccc1",
        "output": "364"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=Cc1ccc(O)cc1.[BH4-].[Na+]>>OCc1ccc(O)cc1",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc2[nH]c(NC(=O)c3ccc4c(c3)CCN(C(=O)OC(C)(C)C)C4)nc12.[Li+].[OH-]>>CC(C)(C)OC(=O)N1CCc2cc(C(=O)Nc3nc4c(C(=O)O)cccc4[nH]3)ccc2C1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)C[AlH]CC(C)C.CCCCCCCCCCCC#Cc1cccc(C=O)c1.Cl>>CCCCCCCCCCCC#Cc1cccc(CO)c1",
        "output": "356"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cccc(-c2nc(N3CCOCC3)nc(Cl)c2CCCl)c1.COc1cccc(-c2nc(N3CCOCC3)nc3c2CCN3c2ccc(C)cn2)c1.Cc1cnc(N)nc1>>Cc1ccc(N2CCc3c(-c4cccc(O)c4)nc(N4CCOCC4)nc32)nc1",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.O.O=C(O)C1Cc2ccccc2N1>>OCC1Cc2ccccc2N1",
        "output": "218"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCO.COCC(=O)N(CC(C)=O)c1c(C)cccc1C.CON.Cl>>COCC(=O)N(CC(C)=NOC)c1c(C)cccc1C",
        "output": "86"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(NC2CC2)CC1.O=C(O)c1cc(F)c(-c2cnco2)c(F)c1>>CC(C)(C)OC(=O)N1CCC(N(C(=O)c2cc(F)c(-c3cnco3)c(F)c2)C2CC2)CC1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1ccnc(N)c1.O=C(Cl)c1ccccc1.c1ccncc1>>CCOC(=O)c1ccnc(NC(=O)c2ccccc2)c1",
        "output": "463"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)[C@@H]2CC[C@]1(C)CN(CCC1C3CC4CC1CC(O)(C4)C3)C2.CI.CN(C)C=O.CN(C)Cc1cc(CN(C)C)c(O)c(CN(C)C)c1.O.[Cl-].[H-].[NH4+].[Na+]>>COC12CC3CC(C1)C(CCN1C[C@H]4CC[C@](C)(C1)C4(C)C)C(C3)C2",
        "output": "140"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN.Cc1cc(C)c(CNC(=O)c2c(C)n([C@H](C)c3ccccc3)c3nc(Cl)ncc23)c(O)n1>>CNc1ncc2c(C(=O)NCc3c(C)cc(C)nc3O)c(C)n([C@H](C)c3ccccc3)c2n1",
        "output": "578"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(N)CO.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc2sc(-c3nn(COCC[Si](C)(C)C)cc3C(=O)O)cc2c1.F[P-](F)(F)(F)(F)F>>Cc1ccc2sc(-c3nn(COCC[Si](C)(C)C)cc3C(=O)NC(C)(C)CO)cc2c1",
        "output": "621"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(CC)(c1ccc(O)c(C)c1)c1ccc(CCC(O)C(C)(C)C)c(C)c1.O=C1c2ccccc2C(=O)N1CCCCCBr>>CCC(CC)(c1ccc(CCC(O)C(C)(C)C)c(C)c1)c1ccc(OCCCCCN2C(=O)c3ccccc3C2=O)c(C)c1",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.CC1=NC(CO)(CCc2ccc(O)cc2)CO1.OCCCC/C=C/I.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC1=NC(CO)(CCc2ccc(OCCCC/C=C/I)cc2)CO1",
        "output": "478"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.COCCOc1ccc(CCN)cc1S(N)(=O)=O.COc1ccc(Cl)cc1C(=O)Cl.Cl.O>>COCCOc1ccc(CCNC(=O)c2cc(Cl)ccc2OC)cc1S(N)(=O)=O",
        "output": "271"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.O=C(O)C(Nc1cccc(F)c1)c1csc2ccccc12.O[C@H]1CN2CCC1CC2.On1nnc2ccccc21>>O=C(O[C@H]1CN2CCC1CC2)C(Nc1cccc(F)c1)c1csc2ccccc12",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CO.Cl.N#Cc1c(OCc2ccccc2)ccc2c1CC[C@@H](N)[C@@H]2O.[Cl-].[Na+]>>CC(C)N[C@@H]1CCc2c(ccc(OCc3ccccc3)c2C#N)[C@H]1O",
        "output": "236"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)c1nc2cc(S(=O)(=O)Cl)ccc2n1CC1CCOCC1.CCNC(=O)c1cc[nH]c1.[H-].[Na+]>>CCNC(=O)c1ccn(S(=O)(=O)c2ccc3c(c2)nc(C(C)(C)C)n3CC2CCOCC2)c1",
        "output": "648"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1cc(C(=O)NCc2ccccc2)ccn1.O=C(Cl)c1cc(F)cc(F)c1.O=C(Cl)c1ccccc1F>>O=C(NCc1ccccc1)c1ccnc(NC(=O)c2cc(F)cc(F)c2)c1",
        "output": "463"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(=O)(=O)Cl.ClCCl.NC[C@H]1CN(c2ccc3cc(-c4ccccc4C(F)(F)F)[nH]c(=O)c3c2)C(=O)O1.O.c1ccncc1>>CS(=O)(=O)NC[C@H]1CN(c2ccc3cc(-c4ccccc4C(F)(F)F)[nH]c(=O)c3c2)C(=O)O1",
        "output": "493"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CC(=O)Cl.CCCCCC.CO.ClCCl.O.OCC(Sc1ccccc1)c1ccccc1.c1ccncc1>>C=CC(=O)OCC(Sc1ccccc1)c1ccccc1",
        "output": "320"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=[N+]([O-])c1cnc(Oc2cccc(S(=O)(=O)NCCN3CCOCC3)c2)cc1Nc1ccccc1.[H][H].[Pd]>>Nc1cnc(Oc2cccc(S(=O)(=O)NCCN3CCOCC3)c2)cc1Nc1ccccc1",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC#N.Cc1ccc(S(=O)(=O)O)cc1.N#CCC(C1CCOCC1)n1cc(-c2ccnc(Cl)n2)cn1.Nc1ccc(N2CCOCC2)cc1.O>>N#CCC(C1CCOCC1)n1cc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cn1",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cccc(C)c1N.ClCCl.O.O=C(Cl)CCl.O=C([O-])[O-].[Na+].[Na+]>>Cc1cccc(C)c1NC(=O)CCl",
        "output": "9"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)CC(C)C.CCC(O)(c1ccc(O)cc1)c1ccccc1OC.Cc1cccc(CCl)n1.O=C([O-])[O-].[K+].[K+]>>CCC(O)(c1ccc(OCc2cccc(C)n2)cc1)c1ccccc1OC",
        "output": "616"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(CO)C(c1ccccc1)c1ccc2c(cnn2-c2ccc(F)cc2)c1.ClCCl.[Na+].[OH-]>>CC(C)(C=O)C(c1ccccc1)c1ccc2c(cnn2-c2ccc(F)cc2)c1",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)CCO.Clc1ccccn1.NCC1CCNCC1.O=C([O-])[O-].[Na+].[Na+]>>NCC1CCN(c2ccccn2)CC1",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCOC(=O)c1cc(N)ncc1Sc1ccc(S(=O)(=O)N2CCCCC2)cc1.CN(C)c1ccncc1.O=S(=O)(Cl)c1ccc(Cl)cc1Cl.c1ccncc1>>CCCCCOC(=O)c1cc(NS(=O)(=O)c2ccc(Cl)cc2Cl)ncc1Sc1ccc(S(=O)(=O)N2CCCCC2)cc1",
        "output": "462"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[O-].CCOC(=O)C1CCNCC1.COc1ncc(Br)cc1C.Cc1ccccc1.[Na+]>>CCOC(=O)C1CCN(c2cnc(OC)c(C)c2)CC1",
        "output": "597"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O=C(CCO)c1ccccc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCC(=O)c1ccccc1",
        "output": "193"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(=O)c1cc(CNC(=O)C(C)C)cnc1C(F)F.O.[Li+].[OH-]>>CC(C)C(=O)NCc1cnc(C(F)F)c(C(=O)O)c1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cc1nn(C2CCCCO2)c2nc(-c3ccc(O)cc3)cc(C(=O)NC3(C)CCN(Cc4ccccc4)CC3)c12.[Pd]>>Cc1nn(C2CCCCO2)c2nc(-c3ccc(O)cc3)cc(C(=O)NC3(C)CCNCC3)c12",
        "output": "84"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.COC(=O)c1ccccc1COc1ccc(CCOS(C)(=O)=O)cc1.O=C([O-])[O-].Oc1ccc(-n2ccnc2)cc1.[K+].[K+]>>COC(=O)c1ccccc1COc1ccc(CCOc2ccc(-n3ccnc3)cc2)cc1",
        "output": "702"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CCN(CC)CC.CCOP(=O)(CCN)OCC.COc1c(C)c2c(c(OCC[Si](C)(C)C)c1CC=C(C)CCC(=O)O)C(=O)OC2.O=C(O)C(=O)O>>CCOP(=O)(CCNC(=O)CCC(C)=CCc1c(OC)c(C)c2c(c1OCC[Si](C)(C)C)C(=O)OC2)OCC",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)N=NC(=O)OCC.C[C@H](CO)NC(=O)OC(C)(C)C.Cc1ccccc1.Oc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C[C@H](COc1ccccc1)NC(=O)OC(C)(C)C",
        "output": "550"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)S(=O)(=O)c1ccccc1Nc1nc(Cl)ncc1Cl.CCO.COCCO.CP(C)(=O)c1ccc(N)c(F)c1.Cl.[Na+].[OH-]>>CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(P(C)(C)=O)cc2F)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.CCOC(C)=O.COC(=O)C1CC1C(=O)Nc1cn2nc(Oc3ccc(C)c(NC(=O)c4cc(C)nn4C)c3)ccc2n1.[BH4-].[Ca+2].[Cl-].[Cl-].[Cl-].[NH4+].[Na+]>>Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5CO)cn4n3)ccc2C)n(C)n1",
        "output": "343"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-n3ncc4ccc(F)cc43)nc12.ClCCl.O=C(O)C(F)(F)F>>CC(C)(C)NC(=O)c1c[nH]c2ncc(-n3ncc4ccc(F)cc43)nc12",
        "output": "981"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1NCCc2c(Br)cccc21.O=C(O)c1cc2ncc(Cl)cn2n1>>CN1c2cccc(Br)c2CCN1C(=O)c1cc2ncc(Cl)cn2n1",
        "output": "995"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCSCC1CCCCc2noc(=O)n21.ClCCl.O=C(OO)c1cccc(Cl)c1>>CCS(=O)CC1CCCCc2noc(=O)n21",
        "output": "13"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)n1ncc2c(C(=O)O)cc(Br)cc21.CN1CCOCC1.CS(C)=O.Cc1cc(C)c(CN)c(=O)[nH]1.ClCCCl.O.On1nnc2cccnc21>>Cc1cc(C)c(CNC(=O)c2cc(Br)cc3c2cnn3C(C)C)c(=O)[nH]1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C=O.CS(=O)(=O)Cl.I.NC(=O)c1cnn2cc(Br)cc2c1N[C@@H]1CNC[C@@H]1CF>>CS(=O)(=O)N1C[C@H](CF)[C@H](Nc2c(C(N)=O)cnn3cc(Br)cc23)C1",
        "output": "584"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCI.CCOc1ccc(-c2ccc3c(c2)COC3=O)c(O)c1OC.O=C([O-])[O-].[K+].[K+]>>CCOc1ccc(-c2ccc3c(c2)COC3=O)c(OCC)c1OC",
        "output": "198"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N1CCC2c3ccccc3OC2C1.O=C([O-])[O-].O=S(=O)(O)Cl.O=S(Cl)Cl.[Na+].[Na+]>>CC(=O)N1CCC2c3cc(S(=O)(=O)Cl)ccc3OC2C1",
        "output": "182"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.ClCCl.Cl[Pd]Cl.Nc1cc(Br)cnc1F.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2cnc(F)c(N)c2)OC1(C)C",
        "output": "943"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCn1c(=O)c2[nH]c(C34CCC(CO)(CC3)CC4)nc2n(CCC)c1=O.CS(=O)(=O)Cl.c1ccncc1>>CCCn1c(=O)c2[nH]c(C34CCC(COS(C)(=O)=O)(CC3)CC4)nc2n(CCC)c1=O",
        "output": "0"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CC1(C)C=Cc2c(ccc(C=O)c2O)O1.CI.O=C([O-])[O-].[K+].[K+]>>COc1c(C=O)ccc2c1C=CC(C)(C)O2",
        "output": "62"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)Cl.O=C1N=C(N2CCN[C@@H](CO)C2)SC1=Cc1ccc2c(cnn2Cc2ccc(C(F)(F)F)cc2C(F)(F)F)c1>>COC(=O)N1CCN(C2=NC(=O)C(=Cc3ccc4c(cnn4Cc4ccc(C(F)(F)F)cc4C(F)(F)F)c3)S2)C[C@@H]1CO",
        "output": "219"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCc1ccccc1.C1CCOC1.C[Si](C)(C)[N-][Si](C)(C)C.Cc1c(-c2cccnc2)[nH]c2ccccc12.Cl.[K+]>>Cc1c(-c2cccnc2)n(Cc2ccccc2)c2ccccc12",
        "output": "528"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1cc(Br)c(O)c(C=O)c1.CC(C)(C)c1cc(C=O)c(O)c(-c2ccc(OC(F)(F)F)cc2)c1.OB(O)c1ccc(C(F)(F)F)cc1C(F)(F)F>>CC(C)(C)c1cc(C=O)c(O)c(-c2ccc(C(F)(F)F)cc2C(F)(F)F)c1",
        "output": "837"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.CC(=O)O.O.O=C(CCc1cc(Br)c(OC(=O)c2c3ccccc3nc3ccccc23)c(Br)c1)OCc1ccccc1>>O=C(O)CCc1cc(Br)c(OC(=O)c2c3ccccc3nc3ccccc23)c(Br)c1",
        "output": "186"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCCCCC.CCOC(C)=O.Cl[Pd]Cl.NC(=O)c1cccc(OCc2ccccc2)c1OCc1ccccc1.O>>N#Cc1cccc(OCc2ccccc2)c1OCc1ccccc1",
        "output": "374"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1scc(C)c1Nc1c(Cl)cccc1Cl.[K+].[OH-]>>Cc1csc(C(=O)O)c1Nc1c(Cl)cccc1Cl",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(CC)CC.ClCCl.O=S(=O)(Cl)c1ccc2c(c1)OCCO2>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccc3c(c2)OCCO3)CC1",
        "output": "99"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C(=O)Nc1ccc(F)c(C2CCN(CCCN)CC2)c1.Cc1ccc(C(C(=O)O)c2ccc(C)cc2)cc1.Cl.ClC(Cl)Cl>>Cc1ccc(C(C(=O)NCCCN2CCC(c3cc(NC(=O)C(C)C)ccc3F)CC2)c2ccc(C)cc2)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CO.COc1ccc(OC)c(Sc2ncccc2C(=O)NCC23CC4CC(CC(C4)C2)C3)c1.ClCCl>>O=C(NCC12CC3CC(CC(C3)C1)C2)c1cccnc1Sc1cc(O)ccc1O",
        "output": "20"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.CCO.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Oc2ccnc(Cl)n2)cn1>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Oc2ccnc(N3CCOCC3)n2)cn1",
        "output": "36"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.CCN(CC)CC.COC(=O)CC(O)C(C)Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1.ClCCl>>COC(=O)CC(OC(C)=O)C(C)Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1",
        "output": "126"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CN(C)C=O.O.O=[N+]([O-])c1c(F)cccc1F.OCc1ccccc1.[H-].[Na+]>>O=[N+]([O-])c1c(F)cccc1OCc1ccccc1",
        "output": "485"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C[C@H](Nc1cncc(-c2cn(S(=O)(=O)c3ccccc3)c3ncc(Cl)cc23)n1)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>C[C@H](Nc1cncc(-c2cn(S(=O)(=O)c3ccccc3)c3ncc(Cl)cc23)n1)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)Cc1cccnc1COC(C)=O.[K+].[OH-]>>CCOC(=O)Cc1cccnc1CO",
        "output": "348"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CCO.O=C1Cc2cc(S(=O)(=O)Cc3ccccc3)ccc2N1.O=Cc1[nH]c2c(c1CCCN1CCOCC1)CCCCC2>>O=C1Nc2ccc(S(=O)(=O)Cc3ccccc3)cc2/C1=C/c1[nH]c2c(c1CCCN1CCOCC1)CCCCC2",
        "output": "911"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.O=C(O)Cc1cccc(F)c1.O=S(=O)(O)O>>CCOC(=O)Cc1cccc(F)c1",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)CC(CN1CCCC(c2cccc(C(F)(F)F)c2)C1)C(F)(F)F.[Na+].[OH-]>>O=C(O)CC(CN1CCCC(c2cccc(C(F)(F)F)c2)C1)C(F)(F)F",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CSCCNCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1.NCc1ccncc1.O=C(Nc1cn(CCBr)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12>>O=C(Nc1cn(CCNCc2ccncc2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12",
        "output": "147"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.C[C@H](N)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O.Cc1nc(F)ccc1C#N>>Cc1nc(N[C@@H](C)c2cc3cc(Cl)c(OCc4ccccn4)cc3[nH]c2=O)ccc1C#N",
        "output": "810"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.O=C(Cl)c1ccccc1.O=C1NC(c2ccccc2)CN1S(=O)(=O)c1ccc2c(c1)CCN2.c1ccncc1>>O=C(c1ccccc1)N1CCc2cc(S(=O)(=O)N3CC(c4ccccc4)NC3=O)ccc21",
        "output": "614"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cccc2c1C[C@@H](N(C)C)CC2.N.O=C(O)C(F)(F)F.O=[N+]([O-])[O-].[Na+]>>COc1ccc([N+](=O)[O-])c2c1C[C@@H](N(C)C)CC2",
        "output": "103"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNC1.CCN=C=NCCCN(C)C.CN(C)C=O.O.O=C(O)[C@H]1CCCN1C(=O)OCc1ccccc1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>O=C([C@H]1CCCN1C(=O)OCc1ccccc1)N1CCCC1",
        "output": "685"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1c[nH]cn1.O.O=C([O-])[O-].O=[N+]([O-])c1c(F)cc(C(F)(F)F)cc1F.[K+].[K+]>>Cc1cn(-c2cc(C(F)(F)F)cc(F)c2[N+](=O)[O-])cn1",
        "output": "721"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.O=[Mn]=O.OCc1ccc(NC2CCN(Cc3ccccc3)C2)nc1>>O=Cc1ccc(NC2CCN(Cc3ccccc3)C2)nc1",
        "output": "520"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(CC1(c2ccc(I)cc2)CCN(C(=O)OC(C)(C)C)CC1)C(=O)Nc1cc(Cl)cc(Cl)c1.ClCCl.O=C(O)C(F)(F)F>>CN(CC1(c2ccc(I)cc2)CCNCC1)C(=O)Nc1cc(Cl)cc(Cl)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)Nc1nc2ccc(F)cc2nc1OC.COc1ccc(N2CCNCC2)cc1>>COc1ccc(N2CCN(C(=O)Nc3nc4ccc(F)cc4nc3OC)CC2)cc1",
        "output": "613"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "N#Cc1cc(C=O)ccc1F.Oc1cncc(C(F)(F)F)c1>>N#Cc1cc(C=O)ccc1Oc1cncc(C(F)(F)F)c1",
        "output": "845"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)C1NS(=O)(=O)c2ccc(Br)cc21.O.O.[Li]O>>O=C(O)C1NS(=O)(=O)c2ccc(Br)cc21",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)CCCBr>>CCOC(=O)CCCBr",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(OC)c(P(C2CCCCC2)C2CCCCC2)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.C[Si](C)(C)[N-][Si](C)(C)C.Nc1ccccn1.O=C1NCCc2[nH]c(-c3cccc4ccc(Cl)nc34)cc21.[Li+]>>O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5ccccn5)nc34)cc21",
        "output": "606"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCN1.CCOCc1nc2cnc3ccccc3c2n1CCCCCC(=O)OCC>>CCOCc1nc2cnc3ccccc3c2n1CCCCCC(=O)N1CCOCC1",
        "output": "494"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1CCCO1.CCCC[N+](CCCC)(CCCC)CCCC.COC1(c2ccc(C(F)(F)F)cc2CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCO[Si](C)(C)C(C)(C)C)n2)CCCCCC1.[F-]>>COC1(c2ccc(C(F)(F)F)cc2CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCO)n2)CCCCCC1",
        "output": "708"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].C[C@H](N)c1ccccc1.Cc1cc(-c2ccnc(Cl)c2)nc(N2CC3CC2CN3C(=O)OC(C)(C)C)n1.Cc1ccccc1.ClCCl.[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Cc1cc(-c2ccnc(N[C@@H](C)c3ccccc3)c2)nc(N2CC3CC2CN3C(=O)OC(C)(C)C)n1",
        "output": "612"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)c1ccncc1.CS(=O)(=O)Cl.Nc1ccc(C(F)(F)F)cc1I.c1ccncc1>>CS(=O)(=O)Nc1ccc(C(F)(F)F)cc1I",
        "output": "194"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Cc1cn(Cc2cccc(Br)c2)c2ccc(OCc3ccccc3)cc12.CCOC(C)=O.COCCOC.Cc1cc(B(O)O)ccc1F.O.O=C([O-])[O-].[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(-c2cccc(Cn3cc(CC(=O)OC(C)(C)C)c4cc(OCc5ccccc5)ccc43)c2)ccc1F",
        "output": "908"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#CCO.CCN(CC)CC.COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2ccc(I)cc2)cc1.I[Cu]I.O.[Cu]I>>COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2ccc(C#CCO)cc2)cc1",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCCc1ccccc1.CCO.Cl.O.O=C(O)C=Cc1ccc(O)cc1.[Na+].[OH-]>>O=C(O)C=Cc1ccc(OCCc2ccccc2)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)c(F)c2)c(=O)n([C@@H]2CC[C@@H](OCC(C)(C)O)CC2)c2ncnn12.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)c(F)c2)c(=O)n([C@@H]2CC[C@@H](OCC(C)(C)O)CC2)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCOC(=O)C(N)C(C[N+](=O)[O-])c1ccccc1.CCOC(C)=O.O.O=C(O)c1ccc(F)cc1C(F)(F)F>>CCOC(=O)C(NC(=O)c1ccc(F)cc1C(F)(F)F)C(C[N+](=O)[O-])c1ccccc1",
        "output": "709"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(N)Cc1c[nH]c2ccccc12.Clc1cc(N2CCCCC2)nc(Cl)n1.Clc1ccccc1.O=C([O-])[O-].[K+].[K+]>>CC(Cc1c[nH]c2ccccc12)Nc1nc(Cl)cc(N2CCCCC2)n1",
        "output": "544"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCN1.CC(=O)Cc1ccnc(Cl)c1>>CC(=O)Cc1ccnc(N2CCOCC2)c1",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.O=C(C1=COc2cc(O)ccc2O1)N1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1.O=C([O-])O.[Na+].c1ccncc1>>CC(=O)Oc1ccc2c(c1)OC=C(C(=O)N1CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC1)O2",
        "output": "46"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(N)CS(=O)(=O)CCO.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1ccc(Oc2ccc(Nc3ncnc4c3C=C(C(=O)O)CCN4)cc2C)cn1.Cl.Cl.O.On1nnc2ccccc21>>Cc1ccc(Oc2ccc(Nc3ncnc4c3C=C(C(=O)NC(C)(C)CS(=O)(=O)CCO)CCN4)cc2C)cn1",
        "output": "549"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(C#N)(CCO)CC1.CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N1CCC(C#N)(CCOS(C)(=O)=O)CC1",
        "output": "0"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.Nc1ccc2c(c1)OCO2.O=C([O-])O.[Na+]>>CC(=O)Nc1ccc2c(c1)OCO2",
        "output": "646"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br.OCCc1ccncc1>>BrCCc1ccncc1",
        "output": "224"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C(C)(C)Oc1ccc(OCCc2nc(-c3ccc(-c4ccccc4)cc3)oc2C)cc1.CO.[Na+].[OH-]>>Cc1oc(-c2ccc(-c3ccccc3)cc2)nc1CCOc1ccc(OC(C)(C)C(=O)O)cc1",
        "output": "192"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNC1.CCn1cc(-c2ccnc3c2cc(-c2cccc(C=O)c2)n3S(=O)(=O)c2ccccc2)c(-c2ccc([N+](=O)[O-])cc2)n1>>CCn1cc(-c2ccnc3c2cc(-c2cccc(CN4CCCC4)c2)n3S(=O)(=O)c2ccccc2)c(-c2ccc([N+](=O)[O-])cc2)n1",
        "output": "567"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Cl.CCOC(=O)C(C)c1ccc(OC)cc1>>CCOC(=O)C(C)c1ccc(OC)c(C(C)=O)c1",
        "output": "31"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.COC(=O)C(CNCc1ccccc1)C(O)c1ccc(Cl)c(F)c1.Cl.[BH4-].[Ca+2].[Cl-].[Cl-].[Na+].[Na+].[OH-]>>OCC(CNCc1ccccc1)C(O)c1ccc(Cl)c(F)c1",
        "output": "343"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(CCCOc2ccc3c(c2)C(=O)C(c2cnc4ccccc4c2)=C3c2cc(F)cc(F)c2)CC1.ClCCl.O=C(O)C(F)(F)F.[Na+].[OH-]>>O=C1C(c2cnc3ccccc3c2)=C(c2cc(F)cc(F)c2)c2ccc(OCCCN3CCNCC3)cc21",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Nc1ccc(Cl)cc1[N+](=O)[O-].O=C(Cl)CCBr.c1ccccc1>>O=C(CCBr)Nc1ccc(Cl)cc1[N+](=O)[O-]",
        "output": "9"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)CCc1cccc(NC(=O)OC(C)(C)C)c1.Cl.[H-]>>CC(C)(C)OC(=O)Nc1cccc(CCCO)c1",
        "output": "225"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.O=C(CCl)Nc1ccccc1.O=C([O-])[O-].Oc1ccc(O)cc1.[K+].[K+]>>O=C(COc1ccc(O)cc1)Nc1ccccc1",
        "output": "458"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)c1c(C)n(CC(=O)O)c2ccccc12.N[C@@H](Cc1cc(F)cc(F)c1)c1ncccc1-c1ccc(Cl)cc1.O=C(O)C(F)(F)F>>CC(=O)c1c(C)n(CC(=O)N[C@@H](Cc2cc(F)cc(F)c2)c2ncccc2-c2ccc(Cl)cc2)c2ccccc12",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)C=C(C)c1ccc(C2CCCC2)cc1.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(=CCO)c1ccc(C2CCCC2)cc1",
        "output": "150"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.Cl[Pd]Cl.O.O=C(Nc1c[nH]c2ncc(Br)cc12)c1cnn(Cc2ccccc2)c1.O=C([O-])[O-].O=Cc1ccc(B(O)O)cc1.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=Cc1ccc(-c2cnc3[nH]cc(NC(=O)c4cnn(Cc5ccccc5)c4)c3c2)cc1",
        "output": "833"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CNCCN1.CCn1cc(C(=O)O)c(=O)c2cc(F)c(Cl)cc21>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)cc21",
        "output": "280"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CC(=O)Nc1ccc(S(=O)(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c(OC)c1.ClCCl.O=C(O)C(F)(F)F>>C=CC(=O)Nc1ccc(S(=O)(=O)N2CCNCC2)c(OC)c1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.O=C([O-])CCC(=O)Nc1ncc(-c2ccc3c(c2)Cc2ccccc2-3)s1.[BH4-].[Cl-].[Li+].[Na+]>>O=C(CCCO)Nc1ncc(-c2ccc3c(c2)Cc2ccccc2-3)s1",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC1CNCCN1C(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)n2cc(-c3ccc4[nH]ccc4c3)c3cc(-c4ccc(C=O)cc4)cnc32)cc1.ClCCl.[Na+]>>Cc1ccc(S(=O)(=O)n2cc(-c3ccc4[nH]ccc4c3)c3cc(-c4ccc(CN5CCN(C(=O)OC(C)(C)C)C(C)C5)cc4)cnc32)cc1",
        "output": "567"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.Cc1ccccc1.ClCCCBr>>BrCCCN1CCOCC1",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)Cl.ClCCl.Nc1cc(N2CC=CCC2)nc(N)[n+]1[O-].O.[Na+].[OH-]>>COC(=O)Nc1cc(N2CC=CCC2)nc(N)[n+]1[O-]",
        "output": "502"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.CNOC.Cl.Cn1cnc(S(=O)(=O)N2C[C@@H](C(=O)O)[C@H](c3ccc(F)cc3)C2)c1>>CON(C)C(=O)[C@@H]1CN(S(=O)(=O)c2cn(C)cn2)C[C@H]1c1ccc(F)cc1",
        "output": "54"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCC(N)CC1.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CC[C@@H](C)C1)CC(F)(F)C(=O)N2C.F[P-](F)(F)(F)(F)F>>COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C1CC[C@@H](C)C1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.Fc1ccccc1C1CCNC1.O=C(O)c1nc2c(C(F)(F)F)cc(-c3ccoc3)cn2c1Cl>>O=C(c1nc2c(C(F)(F)F)cc(-c3ccoc3)cn2c1Cl)N1CCC(c2ccccc2F)C1",
        "output": "729"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCOC(=O)c1sc(-c2ccc(OCOC)c(-n3cnnn3)c2)nc1C.Cl>>CCOC(=O)c1sc(-c2ccc(O)c(-n3cnnn3)c2)nc1C",
        "output": "755"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)I.CC(C)O.CCOCC.Cc1cc(Br)cc(C)c1O.[Na+].[OH-]>>Cc1cc(Br)cc(C)c1OC(C)C",
        "output": "318"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)C1CCC(NC(=O)OCc2ccccc2)CC1.[H][H].[Pd]>>CC(C)(C)OC(=O)C1CCC(N)CC1",
        "output": "574"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C)C=O.CO.N#CCCCBr.OCc1nc2ccccc2[nH]1.[H-].[Na+]>>N#CCCCn1c(CO)nc2ccccc21",
        "output": "495"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)c1cc(N)cc(C(C)(C)C)c1O.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>Cc1ccc(S(=O)(=O)Nc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1",
        "output": "68"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCC1CC1.CN(C)C=O.O=C([O-])[O-].Oc1cccc(O)c1.[K+].[K+]>>Oc1cccc(OCC2CC2)c1",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C(=O)OC(C)(C)C)C1CCC(N)CC1.COc1ccc(-c2cncc(F)c2)cc1C=O>>COc1ccc(-c2cncc(F)c2)cc1CNC1CCC(N(C)C(=O)OC(C)(C)C)CC1",
        "output": "468"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#Cc1ccccc1.CC(C)(C)OC(=O)NCCC(O)c1cccc(Br)c1>>CC(C)(C)OC(=O)NCCC(O)c1cccc(C#Cc2ccccc2)c1",
        "output": "659"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C1CC2CC(NCc3ccccc3)CC2C1.O=C[O-].[NH4+].[Pd]>>NC1CC2CC(=O)CC2C1",
        "output": "561"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C1CCN(c2ccccn2)CC1C(=O)Nc1ccc(C)c(I)c1.CCOC(=O)C1CCNCC1.CCOC(C)=O.CCn1ccc2ccc(NC(=O)c3ccc(Cl)nc3)cc21>>CCOC(=O)C1CCN(c2ccc(C(=O)Nc3ccc4ccn(CC)c4c3)cn2)CC1",
        "output": "220"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(CN)CC1.CCN(C(C)C)C(C)C.ClCCl.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)N1CCC(CNC(=O)OCc2ccccc2)CC1",
        "output": "479"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.Cc1cc(C)nc(N2CC3CNCC3C2)n1.O=C(O)c1cc(F)ccc1C(F)(F)F>>Cc1cc(C)nc(N2CC3CN(C(=O)c4cc(F)ccc4C(F)(F)F)CC3C2)n1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCC(c2cccnc2F)CC1=O.O=C(c1ccc(O)cc1)c1nc2ccccc2[nH]1>>CN1CCC(c2cccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)CC1=O",
        "output": "727"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2F)cc1NC(=O)CC(=O)c1cccc(-c2cncnc2)c1.ClCCl.O=C(O)C(F)(F)F>>O=C1CC(c2cccc(-c3cncnc3)c2)=Nc2ccc(-c3ccccc3F)cc2N1",
        "output": "930"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCOC(=O)c1cnc2cncc(-c3ccc(Cl)cc3)c2c1.O.[Li+].[OH-]>>O=C(O)c1cnc2cncc(-c3ccc(Cl)cc3)c2c1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.CN(Cc1ccccc1)c1ccc(Br)cc1.ClCCl.[K+]>>CN(Cc1ccccc1)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1",
        "output": "942"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C[C@H](C(N)=O)N(Cc1ccc(CO)cc1)S(=O)(=O)c1ccc(Cl)cc1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)C[C@H](C(N)=O)N(Cc1ccc(COS(C)(=O)=O)cc1)S(=O)(=O)c1ccc(Cl)cc1",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N2CC=CCC2)CC1.CC[SiH](CC)CC.ClCCl.O=C(O)C(F)(F)F>>C1=CCN(C2CCNCC2)CC1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.C=O.CC(=O)O.CC(=O)O[Na].Cc1sc(N2CCN(C(=O)OC(C)(C)C)CC2)nc1-c1ccc(C(=O)O)cc1.Cl.[BH3-]C#N.[Na+]>>Cc1sc(N2CCN(C)CC2)nc1-c1ccc(C(=O)O)cc1",
        "output": "881"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(OC)c(Cl)c(CBr)c1Cl.CS(C)=O.[C-]#N.[Na+]>>COc1cc(OC)c(Cl)c(CC#N)c1Cl",
        "output": "39"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#CC(=O)OCC.CC#N.CCOC(=O)c1onc(-c2cccc(Cl)c2F)c1C>>Cc1c(-c2cccc(Cl)c2F)noc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.[Pd].c1ccc(COc2ccc(-n3c4ncccc4n4ccnc34)cc2)cc1>>Oc1ccc(-n2c3ncccc3n3ccnc23)cc1",
        "output": "698"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C1CCOC1.CC1(C)OCc2c1nc1ccccc1c2NCCCN1CCCC1=O.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC1(C)OCc2c1nc1ccccc1c2NCCCN1CCCC1",
        "output": "112"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCBr.CC[N+](CC)(CC)Cc1ccccc1.COc1ccc(O)c(Cl)c1.O.[Cl-].[Na+].[OH-]>>COc1ccc(OCCBr)c(Cl)c1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc2ncnc(Oc3cccc(N)c3)c2cc1OC.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Oc2ccccc2)c(C)c1>>COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(C)cc4C)c3)c2cc1OC",
        "output": "948"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CN(C)C1CCNC1.O=S(=O)(Cl)c1ccc(F)c(Br)c1>>CN(C)C1CCN(S(=O)(=O)c2ccc(F)c(Br)c2)C1",
        "output": "99"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.O=C1c2ccc(Cl)cc2C(=O)N1c1ccc([N+](=O)[O-])cc1CO.[H][H].[Ni]>>Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(CO)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cc1cnc(Cl)c(C=O)c1.[BH4-].[Na+]>>Cc1cnc(Cl)c(CO)c1",
        "output": "476"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)=CCC[C@H](C)[C@@H](C)CN=[N+]=[N-].CO.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)=CCC[C@H](C)[C@@H](C)CN",
        "output": "89"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)[C@@H]1C[C@@H](n2cc(-c3cnc(N)c(-c4nc5ccccc5o4)c3)cn2)CN1C(=O)OC(C)(C)C.[K+].[OH-]>>CC(C)(C)OC(=O)N1C[C@H](n2cc(-c3cnc(N)c(-c4nc5ccccc5o4)c3)cn2)C[C@H]1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCNCC.CN(C)C=O.O=C1CC(CCl)CN1Cc1ccccc1>>CCN(CC)CC1CC(=O)N(Cc2ccccc2)C1",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.OC[C@H]1CNC[C@@H]1c1ccccc1>>CC(C)(C)OC(=O)N1C[C@H](CO)[C@@H](c2ccccc2)C1",
        "output": "694"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(C)=O.CS(C)=O.ClCCl.O.O=S(=O)=O.OCc1ccc2c(F)ccc(Br)c2n1.c1ccncc1>>O=Cc1ccc2c(F)ccc(Br)c2n1",
        "output": "263"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(-c2nc3c(c(=O)[nH]2)CCC3)cc1Cl.O=P(Cl)(Cl)Cl.c1cncnc1>>COc1ccc(-c2nc(Cl)c3c(n2)CCC3)cc1Cl",
        "output": "14"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCn1cc(-c2ccc(Cl)cc2Cl)nc1COc1ccc(Br)cc1.OB(O)c1cccc(O)c1>>CCn1cc(-c2ccc(Cl)cc2Cl)nc1COc1ccc(-c2cccc(O)c2)cc1",
        "output": "837"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CC(C)N(C)[C@@H]1CC[C@H](N)[C@H](CO)C1.CN1CCOCC1.O.O=C(O)CNC(=O)c1cccc(C(F)(F)F)c1>>CC(C)N(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CO)C1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1nn(C(=O)OC(C)(C)C)c2cc(-c3ccc4nnn(Cc5ccc6ncccc6c5)c4n3)ccc12.ClCCl.O=C(O)C(F)(F)F.[Na+].[OH-]>>CCc1n[nH]c2cc(-c3ccc4nnn(Cc5ccc6ncccc6c5)c4n3)ccc12",
        "output": "896"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.Cl.N[C@@H](CO)c1ccccc1>>CC(C)(C)OC(=O)N[C@@H](CO)c1ccccc1",
        "output": "686"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)[C@H](COC1CCOCC1)NC(=O)c1cc2ccccc2cc1N.Cc1cc(C)c(N=C=O)c(C)c1.c1ccncc1>>COC(=O)[C@H](COC1CCOCC1)NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C",
        "output": "993"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCOC(=O)c1nc(Cl)c2ccccc2c1O.Oc1cccc(F)c1>>CCCCOC(=O)c1nc(Oc2cccc(F)c2)c2ccccc2c1O",
        "output": "516"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.CS(=O)(=O)OCCC1CCN(c2ccc3cc(Cl)ccc3n2)CC1.[N-]=[N+]=[N-].[Na+]>>[N-]=[N+]=NCCC1CCN(c2ccc3cc(Cl)ccc3n2)CC1",
        "output": "322"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCOC(=O)CCC(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.N[C@@H](CC(=O)OCc1ccccc1)Cc1ccc(-c2cccc(Cl)c2)cc1.O.On1nnc2cccnc21>>CCCCOC(=O)CCC(=O)N[C@@H](CC(=O)OCc1ccccc1)Cc1ccc(-c2cccc(Cl)c2)cc1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.Clc1ncc(Cl)c(-n2nnc3ccccc32)n1.NC1CCCCC1>>Clc1cnc(NC2CCCCC2)nc1-n1nnc2ccccc21",
        "output": "544"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NC1CCCCCC1.O=C(O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1>>O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)NC1CCCCCC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC.COc1cccc(C=O)c1OC.C[Mg]Br>>COc1cccc(C(C)O)c1OC",
        "output": "787"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN1CCOCC1.Cl.N[C@H]1C[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21.O.O=C(O)c1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21.On1nnc2cccnc21>>O=C(N[C@H]1C[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21)c1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(C)=O.CCOC(=O)C(C)Br.CN(c1ccc(O)cc1)c1cnc2cc(Cl)ccc2n1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C(C)Oc1ccc(N(C)c2cnc3cc(Cl)ccc3n2)cc1",
        "output": "455"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)NCCCC(=O)O.CN(C)c1ccncc1.ClCCl.Oc1ccccc1>>CC(C)(C)OC(=O)NCCCC(=O)Oc1ccccc1",
        "output": "108"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCCCCCCCCCCCCCCCCN.CCOC(=O)CNC(C)=O.CCOC(C)=O>>CCCCCCCCCCCCCCCCCCCCCCNC(=O)CNC(C)=O",
        "output": "64"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1CC(O)(CN)CCC1(F)F.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.COCCc1cc(C(=O)O)c2c(Cl)cccn12.Cl.On1nnc2ccccc21>>COCCc1cc(C(=O)NCC2(O)CCC(F)(F)C(C)C2)c2c(Cl)cccn12",
        "output": "674"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.COCCn1cc(C(=O)O)c2c(C)ccc(F)c21.Cl.ClCCl.O=C(NCc1ccc(F)c(C2CCNCC2)c1)C(F)(F)F>>COCCn1cc(C(=O)N2CCC(c3cc(CNC(=O)C(F)(F)F)ccc3F)CC2)c2c(C)ccc(F)c21",
        "output": "256"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOCC.Cl.O=C(O)c1cc(-c2ccc(Cl)cc2)nc(Cl)n1>>CCOC(=O)c1cc(-c2ccc(Cl)cc2)nc(Cl)n1",
        "output": "47"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(CC)CC.Clc1ncc(Br)c(Cl)n1.NCCCCNC(=O)c1cccc([N+](=O)[O-])c1>>O=C(NCCCCNc1nc(Cl)ncc1Br)c1cccc([N+](=O)[O-])c1",
        "output": "110"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C1=C[C@H]2[C@@H](C1)C[C@@]2(CN)CC(=O)OC(C)(C)C.CCOC(C)=O.Cl>>CC(C)C1=C[C@H]2[C@@H](C1)C[C@@]2(CN)CC(=O)O",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.COC(=O)c1ccc(F)c(Br)n1.O.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=Cc1ccc(F)c(B(O)O)c1F.[F-].[K+].[Pd].[Pd]>>COC(=O)c1ccc(F)c(-c2c(F)ccc(C=O)c2F)n1",
        "output": "869"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C(OC(C)(C)C)OC(C)(C)C.Cc1ccccc1.O=C(Nc1cccc(-c2ccc(Cl)cc2)n1)c1ccc(Oc2cc3c(cc2Cl)C(C(=O)O)CCO3)cc1>>CC(C)(C)OC(=O)C1CCOc2cc(Oc3ccc(C(=O)Nc4cccc(-c5ccc(Cl)cc5)n4)cc3)c(Cl)cc21",
        "output": "768"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOc1cc(CC(=O)NC(C(=O)O)c2ccccc2N2CCCCC2)ccc1C(=O)OCc1ccccc1.CI.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOc1cc(CC(=O)NC(C(=O)OC)c2ccccc2N2CCCCC2)ccc1C(=O)OCc1ccccc1",
        "output": "415"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COc1ccc(CCCC(c2ccc(F)c(F)c2)N2C(=O)c3ccccc3C2=O)cc1.Cl.NN>>COc1ccc(CCCC(N)c2ccc(F)c(F)c2)cc1",
        "output": "418"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.O.O=Cc1ccc(O)c([N+](=O)[O-])c1.OCCO.c1ccccc1>>O=[N+]([O-])c1cc(C2OCCO2)ccc1O",
        "output": "117"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)C(C)=Cc1ccccc1N.COc1cc(N)c(C=C(C)C(=O)NCCc2ccccc2)cc1OC.Cl.[Na+].[OH-]>>CC(=Cc1ccccc1N)C(=O)O",
        "output": "122"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCC.COc1ccccc1C(=O)c1ccccc1OC.ClB(Cl)Cl.ClCCl.O=C([O-])O.[Na+]>>COc1ccccc1C(=O)c1ccccc1O",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.Cl.O=C(Cl)c1ccc(Br)cc1.O=C(c1ccc(Cl)cc1)C1CCNCC1.[Na+].[OH-]>>O=C(c1ccc(Cl)cc1)C1CCN(C(=O)c2ccc(Br)cc2)CC1",
        "output": "201"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)Sc1ccc(S(C)(=O)=O)cc1C(=O)O.FC(F)(F)c1ccc(OC2CCNC2)cc1>>CC(C)Sc1ccc(S(C)(=O)=O)cc1C(=O)N1CCC(Oc2ccc(C(F)(F)F)cc2)C1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.N#Cc1ccc(N)cc1I.O=C1C=CC(=O)O1>>N#Cc1ccc(N2C(=O)C=CC2=O)cc1I",
        "output": "410"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(CO)c1ncccc1Cl.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C=O)c1ncccc1Cl",
        "output": "142"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)N1CCNCC1.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].O=Cc1ccc(F)cc1.[K+].[K+]>>CC(C)N1CCN(c2ccc(C=O)cc2)CC1",
        "output": "26"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCCOc1noc2ccc(F)c(C(=O)O)c12.CC(C)COC(=O)Cl.CCN(CC)CC.N>>CC(C)(C)OC(=O)NCCOc1noc2ccc(F)c(C(N)=O)c12",
        "output": "358"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(=O)Cn1c(CCc2cccc(F)c2F)nc(=O)c2sccc21.[Na+].[OH-]>>O=C(O)Cn1c(CCc2cccc(F)c2F)nc(=O)c2sccc21",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CO.C[Si](C)(C)C=[N+]=[N-].Cc1cccc(CC(=O)O)c1>>COC(=O)Cc1cccc(C)c1",
        "output": "195"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccccc1Nc1ccccc1F.[Pd]>>Nc1ccccc1Nc1ccccc1F",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCO.COC(=O)c1cnc2[nH]c(C(CC3CCCC3)c3ccc(S(C)(=O)=O)nc3)cc2c1.Cl.ClCCl.[Na+].[OH-]>>CS(=O)(=O)c1ccc(C(CC2CCCC2)c2cc3cc(C(=O)O)cnc3[nH]2)cn1",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)N(C)C.CCNC(=O)N1CCCCC1COc1cccc(N)c1C#N.NS(=O)(=O)Cl>>CCNC(=O)N1CCCCC1COc1cccc(NS(N)(=O)=O)c1C#N",
        "output": "395"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCCc2ccc([N+](=O)[O-])cc21.CO.[Pd]>>CC(C)(C)OC(=O)N1CCCc2ccc(N)cc21",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCOC.C1CCOC1.CCN(CC)CC.COC(C)(C)C.Cc1c(Br)cc(C(=O)O)cc1I.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.I[Cu]I.O>>COCC#Cc1cc(C(=O)O)cc(Br)c1C",
        "output": "664"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCc1ccccc1.CC(C)(C)OC(=O)Cc1ccc(C(=O)O)cc1>>CC(C)(C)OC(=O)Cc1ccc(C(=O)OCc2ccccc2)cc1",
        "output": "403"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CNCCN1.CN(C)C=O.Clc1nc(-c2ccccc2)nc2ccccc12>>c1ccc(-c2nc(N3CCNCC3)c3ccccc3n2)cc1",
        "output": "296"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCOC(C)=O.COc1cc(CNc2ncc(I)cc2[N+](=O)[O-])ccc1OCc1ccc(C)nc1.[Fe]>>COc1cc(CNc2ncc(I)cc2N)ccc1OCc1ccc(C)nc1",
        "output": "269"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N(NC(=O)c1ccccc1)C(=O)CCc1ccccc1Br.COCCOC.O=C([O-])[O-].OB(O)c1ccc(F)cc1.[Na+].[Na+]>>CC(C)N(NC(=O)c1ccccc1)C(=O)CCc1ccccc1-c1ccc(F)cc1",
        "output": "837"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)C=O.CNOC.COc1cc(C(=O)O)ccn1.Cl.ClCCl.O=C(Cl)C(=O)Cl>>COc1cc(C(=O)N(C)OC)ccn1",
        "output": "828"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)[C@H]1CCCN(C(=O)c2ccccc2)C1.O=C(O)C1CCCN(C(=O)Cc2cccs2)C1.[Na+].[OH-]>>O=C(O)[C@H]1CCCN(C(=O)c2ccccc2)C1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccccc1.CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O.CO.CO.C[O-].O.[Na+]>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)O",
        "output": "127"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCCCC1CN.Clc1ccc2ccccc2n1>>CC(C)(C)OC(=O)N1CCCCC1CNc1ccc2ccccc2n1",
        "output": "70"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N1Cc2cc(F)c(Cl)nc2C=Cc2ccccc21.CC1(C)OB(c2ccc(N3CCOCC3)nc2)OC1(C)C.COc1ccc(-c2nc3c(cc2F)CN(C(C)=O)c2ccccc2C=C3)cn1>>CC(=O)N1Cc2cc(F)c(-c3ccc(N4CCOCC4)nc3)nc2C=Cc2ccccc21",
        "output": "968"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.C1CCOC1.CCOC(C)=O.O=C([O-])[O-].OCCCBr.[K+].[K+]>>OCCCN1CCCC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COc1ccccc1-c1cn(S(=O)(=O)c2ccc(C)cc2)c2ncc(-c3cccc(C(O)c4ncccc4C(F)(F)F)c3)cc12.Cl.[Na+].[OH-]>>COc1ccccc1-c1c[nH]c2ncc(-c3cccc(C(O)c4ncccc4C(F)(F)F)c3)cc12",
        "output": "949"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccccc1CNCC(F)(F)F.O=C(O)CCCSc1ccc(F)cc1>>COc1ccccc1CN(CC(F)(F)F)C(=O)CCCSc1ccc(F)cc1",
        "output": "633"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N(CCO)CCO.CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCCCCC.CCOC(C)=O.CN(C)C=O.ClCCl.c1c[nH]cn1>>CC(C)(C)OC(=O)N(CCO)CCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C",
        "output": "602"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(O)CCl.O.O=[N+]([O-])c1ccccc1S.[Na+].[OH-]>>CC(O)CSc1ccccc1[N+](=O)[O-]",
        "output": "460"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COc1cc(N2CCNCC2)cc(OC)n1.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)/C=C/C(F)(F)C(F)(F)F>>COc1cc(N2CCN(C(=O)/C=C/C(F)(F)C(F)(F)F)CC2)cc(OC)n1",
        "output": "870"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cc(F)cc(NS(=O)(=O)CC2CN(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)C2)c1.CCOCC.O.O=P([O-])([O-])O.[Li+].[Na+].[Na+].[OH-]>>O=C(O)c1cc(F)cc(NS(=O)(=O)CC2CN(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)C2)c1",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COCOc1c(-c2csc3ccc(C(C)=CC(=O)OC)cc23)cc(C(C)C)cc1C(C)C.Cl>>COC(=O)C=C(C)c1ccc2scc(-c3cc(C(C)C)cc(C(C)C)c3O)c2c1",
        "output": "755"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=CC(=O)Cl.CC(C)(C)OC(=O)N[C@@H](CC1CCNCC1)C(=O)O.O.[Na+].[OH-]>>C=CC(=O)N1CCC(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)CC1",
        "output": "135"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1cnnn1-c1nc2c(s1)CCOc1cc(Br)ccc1-2.CO.[Pd]>>CC(C)(C)c1cnnn1-c1nc2c(s1)CCOc1ccccc1-2",
        "output": "350"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCSCc1cccc2c(C(CCOS(C)(=O)=O)c3ccc(Cl)cc3)c[nH]c12.CN(C)C=O.O.[C-]#N.[K+]>>CCSCc1cccc2c(C(CCC#N)c3ccc(Cl)cc3)c[nH]c12",
        "output": "705"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cc1noc(C)c1-c1cc([N+](=O)[O-])c(N)c(S(=O)(=O)NC2CCCC2)c1.[Pd]>>Cc1noc(C)c1-c1cc(N)c(N)c(S(=O)(=O)NC2CCCC2)c1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccnc(Cl)n2)CC1.OCc1cccc(Cl)n1>>CC(C)(C)OC(=O)N1CCN(c2ccnc(OCc3cccc(Cl)n3)n2)CC1",
        "output": "37"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2cc3nn2c1N1CCC(C)(CC1)OCCCCc1cc(F)c(F)cc1COC3.[Na+].[OH-]>>Cc1nc2cc3nn2c(c1[C@H](OC(C)(C)C)C(=O)O)N1CCC(C)(CC1)OCCCCc1cc(F)c(F)cc1COC3",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.CCCn1nc(-c2ccc(OC)c(Cl)c2)c2cccc(Cl)c21>>CCCn1nc(-c2ccc(O)c(Cl)c2)c2cccc(Cl)c21",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@H](Cc1ccc(-c2ccncc2)cc1)C(=O)O.CCOC(C)=O.CN(C)C=O.ClCCCl.O.O.On1nnc2ccccc21.[NH4+].[OH-]>>CC(C)(C)OC(=O)N[C@H](Cc1ccc(-c2ccncc2)cc1)C(N)=O",
        "output": "313"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.COC(=O)CCn1cnc2c(=O)n(Cc3ccccc3)cnc21.NCCCN1CCOCC1>>O=C(CCn1cnc2c(=O)n(Cc3ccccc3)cnc21)NCCCN1CCOCC1",
        "output": "392"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCc1ccc2ccncc2c1.COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2O)cc1>>COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCc2ccc3ccncc3c2)cc1",
        "output": "464"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.OCCNCCO>>CC(C)(C)OC(=O)N(CCO)CCO",
        "output": "694"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.CS(=O)(=O)c1ncc(C(F)(F)F)cn1.O.O=C([O-])[O-].OC1CCNCC1.[K+].[K+]>>OC1CCN(c2ncc(C(F)(F)F)cn2)CC1",
        "output": "679"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.COC(=O)Cc1nc(NC(=O)C(C)(Oc2ccc(F)cc2F)c2ccc(S(C)(=O)=O)cc2)sc1Cl.O.[Li+].[OH-]>>CC(Oc1ccc(F)cc1F)(C(=O)Nc1nc(CC(=O)O)c(Cl)s1)c1ccc(S(C)(=O)=O)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1ccc(C2CC(C(=O)Nc3ccccc3)CN(C(=O)C3(NC(=O)OC(C)(C)C)CC3)C2)cc1.ClCCl.O=C(O)C(F)(F)F>>CCc1ccc(C2CC(C(=O)Nc3ccccc3)CN(C(=O)C3(N)CC3)C2)cc1",
        "output": "431"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)C(C)(C)Sc1nc(CC(=O)O)cs1.CO.N.[Cl-]>>CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCO)cs1",
        "output": "231"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.ClCCl.OC1CCCNC1>>CC(=O)N1CCCC(O)C1",
        "output": "369"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1c(C)[nH]c(C=O)c1CCC(=O)O.O=C1Cc2c(cccc2C2CCNCC2)N1>>CCOC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3cccc(C4CCNCC4)c32)c1CCC(=O)O",
        "output": "440"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CC(c1ccccc1)c1cc(Br)cc(NC(=O)Nc2ccc(C)cc2)c1NCC(C)C.Cc1ccc(NC(=O)Nc2cc(Br)ccc2N(CC(C)C)CC(C)C)cc1.OB(O)c1ccccc1-c1nnn[nH]1>>C=CC(c1ccccc1)c1cc(-c2ccccc2-c2nnn[nH]2)cc(NC(=O)Nc2ccc(C)cc2)c1NCC(C)C",
        "output": "837"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.Cc1ccc(-c2cc(CCCO)nn2-c2ccc(S(N)(=O)=O)cc2)cc1.O=C1NC(=O)c2ccccc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1ccc(-c2cc(CCCN3C(=O)c4ccccc4C3=O)nn2-c2ccc(S(N)(=O)=O)cc2)cc1",
        "output": "420"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)C1C2CC(O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)CC21.CCOC(=O)C(=O)OCC.C[Si](C)(C)[N-][Si](C)(C)C.[Li+]>>CCOC(=O)C(=O)CC(=O)C1C2CC(O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)CC21",
        "output": "526"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1C[C@H]2CNC[C@@H](C1)C2O.CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)O)cn3)nc2n1C1CCCCCC1.[Cl-].[Li+]>>CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4C[C@@H]5CN(C(=O)OC(C)(C)C)C[C@H](C4)C5O)cn3)nc2n1C1CCCCCC1",
        "output": "256"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1cc(Nc2ncnc3cnc(F)cc23)ccc1OC1CCN(C(=O)Nc2c(F)cccc2F)CC1.Cc1cc(Nc2ncnc3cnc(N4CCOCC4)cc23)ccc1OC1CCNCC1.O=C=NC1CCCC1>>Cc1cc(Nc2ncnc3cnc(N4CCOCC4)cc23)ccc1OC1CCN(C(=O)NC2CCCC2)CC1",
        "output": "437"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)[C@@H]1C[C@@H](OCc2ccccc2)CN1C(=O)OC(C)(C)C.[Na+].[OH-]>>CC(C)(C)OC(=O)N1C[C@H](OCc2ccccc2)C[C@H]1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC(=O)Cl.ClCCl.Fc1cccc2cccc(F)c12.[Al+3].[Cl-].[Cl-].[Cl-]>>CCC(=O)c1ccc(F)c2c(F)cccc12",
        "output": "31"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Br[Mg]c1ccccc1.CC(C)(C)c1cccc(C=O)c1OCc1ccccc1>>CC(C)(C)c1cccc(C(O)c2ccccc2)c1OCc1ccccc1",
        "output": "309"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)C[C@@H]1C[C@@H]2CC[C@H]1O2.O.O.[Li]O>>O=C(O)C[C@@H]1C[C@@H]2CC[C@H]1O2",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN=C=NCCCN(C)C.ClCCl.N#CCC(=O)O.NC1CCCCC1>>N#CCC(=O)NC1CCCCC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cccc2cc(C(=O)O)c(=O)oc12.F[P-](F)(F)(F)(F)F.Nc1cccc(-c2ccc3c(c2)OCO3)c1>>COc1cccc2cc(C(=O)Nc3cccc(-c4ccc5c(c4)OCO5)c3)c(=O)oc12",
        "output": "799"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccccc1Nc1cc(-c2ccc(NS(C)(=O)=O)cc2)ccc1C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>Cc1ccccc1Nc1cc(-c2ccc(NS(C)(=O)=O)cc2)ccc1C(=O)O",
        "output": "752"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1nc([C@@H](N)CC2CC2)no1.O=C(O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1>>Cc1nc([C@H](CC2CC2)NC(=O)c2cnc(N3CC(F)(F)C3)c(OCC3CC3)n2)no1",
        "output": "697"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CCCO.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>C#CCCOS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC#N.CCN(CC)CC.CCN=C=NCCCN(C)C.COC(=O)c1ccc(CNCC(C)O)cc1.Cl.O.O=C(O)c1ccc(Cl)cc1C(=O)c1ccccc1.On1nnc2ccccc21>>COC(=O)c1ccc(CN(CC(C)O)C(=O)c2ccc(Cl)cc2C(=O)c2ccccc2)cc1",
        "output": "794"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CS(=O)(=O)c1nccc(-c2cc3c(NC(=O)OCc4ccccc4)n[nH]c3nc2-c2cccc(C(F)(F)F)c2)n1.NCC1CC1>>O=C(Nc1n[nH]c2nc(-c3cccc(C(F)(F)F)c3)c(-c3ccnc(NCC4CC4)n3)cc12)OCc1ccccc1",
        "output": "629"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.O=C1CCc2c(Br)cncc21.[BH4-].[Na+]>>OC1CCc2c(Br)cncc21",
        "output": "449"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.COc1cc(Nc2nc(-c3ccc(Cl)nc3)nn3c(C)nc(C)c23)cc(OC)c1OC.O.O=C([O-])[O-].[K+].[K+]>>COc1cc(Nc2nc(-c3ccc(N4CCOCC4)nc3)nn3c(C)nc(C)c23)cc(OC)c1OC",
        "output": "220"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C[C@@H](N)c1cccc2ccccc12.O=Cc1cccc(C#Cc2ccccc2)c1>>C[C@@H](NCc1cccc(C#Cc2ccccc2)c1)c1cccc2ccccc12",
        "output": "683"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](F)[C@H](O)C1.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>Cc1ccc(S(=O)(=O)O[C@@H]2CN(C(=O)OC(C)(C)C)CC[C@H]2F)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CCn2c(cc(Cl)nc2=O)N1C.OCc1cc(F)c(F)c(F)c1>>CC1CCn2c(cc(OCc3cc(F)c(F)c(F)c3)nc2=O)N1C",
        "output": "653"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)c1ccc(Oc2ccc(O)cc2N)cc1.CC(C)(C)c1ccc(Oc2ccc(OCc3ccccc3)cc2[N+](=O)[O-])cc1.CC(C)O.CCCCC(Oc1ccc(C(C)(C)CC)cc1C(C)(C)CC)C(=O)Cl.Cc1ccccc1.O.O=C[O-].[K+].[Pd]>>CCCCC(Oc1ccc(C(C)(C)CC)cc1C(C)(C)CC)C(=O)Nc1cc(O)ccc1Oc1ccc(C(C)(C)C)cc1",
        "output": "9"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cccc(C(=O)O)c1Cl.NCC1(c2ccc(C(F)(F)F)nc2)CCC(F)(F)CC1>>COc1cccc(C(=O)NCC2(c3ccc(C(F)(F)F)nc3)CCC(F)(F)CC2)c1Cl",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CI.COC[C@@H](NC(C)=O)C(=O)NCc1ccccc1.O=C(O)[C@@H](CO)NC(c1ccccc1)(c1ccccc1)c1ccccc1>>COC[C@@H](NC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)O",
        "output": "140"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COc1cc(CCCCCCCCc2ccc(NC(C)=O)cc2)c2ccccc2c1OC.Cl>>COc1cc(CCCCCCCCc2ccc(N)cc2)c2ccccc2c1OC",
        "output": "66"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.CCOC(C)=O.Cc1ccc(C(=O)Nc2ccc(C)c(-c3nc(S(C)(=O)=O)nc4c3CNC(=O)N4c3c(F)cccc3F)c2)cc1F.[H-].[Na+]>>Cc1ccc(C(=O)Nc2ccc(C)c(-c3nc(OC(C)C)nc4c3CNC(=O)N4c3c(F)cccc3F)c2)cc1F",
        "output": "667"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)/C=C/c1ccc(OCCOC)cc1Nc1ccc(C(F)(F)F)cc1.[Na+].[OH-]>>COCCOc1ccc(/C=C/C(=O)O)c(Nc2ccc(C(F)(F)F)cc2)c1",
        "output": "122"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Nc1ccc(-n2ccccc2=O)cc1F.O=C(O)Cn1ccc(NC(=O)c2ccc(Cl)s2)n1>>O=C(Cn1ccc(NC(=O)c2ccc(Cl)s2)n1)Nc1ccc(-n2ccccc2=O)cc1F",
        "output": "365"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.C[C@@H](O)[C@@H]1C(=O)N2[C@@H](C(=O)OCc3ccccc3)C(C)(C)S(=O)(=O)[C@H]12.c1c[nH]cn1>>C[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H]1C(=O)N2[C@@H](C(=O)OCc3ccccc3)C(C)(C)S(=O)(=O)[C@H]12",
        "output": "193"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.O.O=C([O-])[O-].Oc1cccc(I)c1Br.[K+].[K+]>>COc1cccc(I)c1Br",
        "output": "62"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)N=NC(=O)OCC.CN(C)c1cccc(OCCO)c1.COC(=O)c1nc(Br)ccc1O.ClCCl>>COC(=O)c1nc(Br)ccc1OCCOc1cccc(N(C)C)c1",
        "output": "547"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrC(Br)(Br)Br.CC(C)Cc1cc(-c2ccc(CO)cc2)c(S(=O)(=O)NC(C)(C)C)s1.CCOC(C)=O.CN(C)C=O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)Cc1cc(-c2ccc(CBr)cc2)c(S(=O)(=O)NC(C)(C)C)s1",
        "output": "750"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1ccc(N)cc1.COc1cccc2cc(C(=O)O)oc12>>COc1cccc2cc(C(=O)Nc3ccc(C(C)(C)C)cc3)oc12",
        "output": "860"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(ON1C(=O)CCC1=O)=[N+](C)C.COc1cnn(C(CC2CCCC2)C(=O)O)c(=O)c1.ClCCl.F[B-](F)(F)F.Nc1nccs1>>COc1cnn(C(CC2CCCC2)C(=O)Nc2nccs2)c(=O)c1",
        "output": "681"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCCCOc1ccccc1[N+](=O)[O-].[C].[Pd]>>CC(C)(C)[Si](C)(C)OCCCOc1ccccc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.OCCCCCCCOC1CCCCO1.c1ccccc1>>CS(=O)(=O)OCCCCCCCOC1CCCCO1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CS(=O)(=O)Nc1cc([C@@H](O)CN)ccc1O.O=C1CCN(c2ccc(C=C3SC(N4CCCCC4)=NC3=O)cc2)CC1>>CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(C=C4SC(N5CCCCC5)=NC4=O)cc3)CC2)ccc1O",
        "output": "236"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.CCCI.COc1cccc(CCNCCC2CCCCC2)c1.Cl.O=C([O-])[O-].[K+].[K+]>>CCCN(CCc1cccc(OC)c1)CCC1CCCCC1",
        "output": "184"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)O.COc1ccc(N)cc1O.Cl.O=C(Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Cl)n2)c1)c1c(F)cccc1F>>COc1ccc(Nc2nccc(-c3c(-c4cccc(NC(=O)c5c(F)cccc5F)c4)nn4ccccc34)n2)cc1O",
        "output": "907"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCC.CN(C)C=O.Cc1noc(-c2cccnc2Cl)n1.O.OCc1ccccc1.[H-].[Na+]>>Cc1noc(-c2cccnc2OCc2ccccc2)n1",
        "output": "433"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(=O)O.CCOC(C)=O.COC(=O)c1cccc2c1OCC(c1cncc(OC3CCN(C(=O)C(C)C)CC3)c1)O2.O.O.[Li+].[OH-]>>CC(C)C(=O)N1CCC(Oc2cncc(C3COc4c(cccc4C(=O)O)O3)c2)CC1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#Cc1ccc(N)nc1.C1CCOC1.CCN(CC)CC.O.ON=C(Cl)Cc1ccc(Oc2ccccc2F)nc1>>Nc1ccc(-c2cc(Cc3ccc(Oc4ccccc4F)nc3)no2)cn1",
        "output": "976"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOP(=O)(CCOC(C)=O)OCC.O=S(=O)(O)O>>CCOP(=O)(CCO)OCC",
        "output": "225"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.COc1cc(B(O)O)c(Cl)cn1.Cl[Pd+].FC(F)(F)c1ccc(Cl)cc1Br.NCCc1[c-]cccc1>>COc1cc(-c2cc(Cl)ccc2C(F)(F)F)c(Cl)cn1",
        "output": "904"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC[C@H](N)c1ccccc1Cl.Cl.O=C(O)c1ccc2[nH]nc(I)c2c1>>CC[C@H](NC(=O)c1ccc2[nH]nc(I)c2c1)c1ccccc1Cl",
        "output": "753"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CN(C)C(=O)COc1ccc2c(c1)N(c1nc(-c3ccc(F)c(F)c3)nc3c1CSC3)CC2.O.O=C(OO)c1cccc(Cl)c1.[Cl-].[Na+]>>CN(C)C(=O)COc1ccc2c(c1)N(c1nc(-c3ccc(F)c(F)c3)nc3c1CS(=O)C3)CC2",
        "output": "13"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cn(-c2ccc(N)cc2F)nn1.O=C(Cl)OCc1ccccc1>>Cc1cn(-c2ccc(NC(=O)OCc3ccccc3)cc2F)nn1",
        "output": "509"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C[C@H](NCCc1c[nH]c2c(OCC(=O)[O-])cccc12)[C@H](O)c1ccc(O)cc1.Cl.O.[Li+].[OH-]>>C[C@H](NCCc1c[nH]c2c(OCC(=O)O)cccc12)[C@H](O)c1ccc(O)cc1",
        "output": "151"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CO.Nc1ccccc1.O=C1CCC2(CC1)OCCO2.[BH3-]C#N.[Na+].[Na+].[OH-]>>c1ccc(NC2CCC3(CC2)OCCO3)cc1",
        "output": "469"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1CN(c2ccc(Cl)c(Cl)c2)N=C1NC=O.O=CO>>CC1CN(c2cccc(Cl)c2)N=C1NC=O",
        "output": "253"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc([N+](=O)[O-])c(N)n1.Cc1nc(N)ccc1[N+](=O)[O-].O=S(=O)(O)O.O=[N+]([O-])O>>Cc1nc(N)c([N+](=O)[O-])cc1[N+](=O)[O-]",
        "output": "328"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cc1ccccc1.ClCCl.Cl[Pd]Cl.Nc1ncc(Br)nc1C(=O)Nc1cccnc1.O=C([O-])[O-].OB(O)c1ccccc1.[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Nc1ncc(-c2ccccc2)nc1C(=O)Nc1cccnc1",
        "output": "876"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC(=O)Cl.CCN(C(C)C)C(C)C.COC(=O)C1(NC(=O)c2cc3ccccc3cc2NC(=O)Nc2c(C)cc(C)cc2C)CCNCC1.ClCCl>>CCCC(=O)N1CCC(NC(=O)c2cc3ccccc3cc2NC(=O)Nc2c(C)cc(C)cc2C)(C(=O)OC)CC1",
        "output": "125"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)[C@H](CO)NC(=O)C(C)(C)NC(=O)OCc1ccccc1.CO.[C].[Pd]>>CCOC(=O)[C@H](CO)NC(=O)C(C)(C)N",
        "output": "128"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.COC(=O)c1ccnc(Cl)c1.C[O-].O.[Na+]>>COC(=O)c1ccnc(OC)c1",
        "output": "433"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)c1ccc(B(O)O)cc1.COC(=O)c1cc(-n2cc(-c3ccc(Cl)cc3Cl)nc2Cc2ccc(-c3ccc(O)cc3)cc2)ccc1C(F)(F)F>>COC(=O)c1cc(-n2cc(-c3ccc(Cl)cc3Cl)nc2Cc2ccc(-c3ccc(Oc4ccc(C(C)(C)C)cc4)cc3)cc2)ccc1C(F)(F)F",
        "output": "920"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc(N)cc1.O=C(O)c1cccc(S(=O)(=O)N2CCCCC2)c1>>Cc1ccc(NC(=O)c2cccc(S(=O)(=O)N3CCCCC3)c2)cc1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=S(=O)(c1ccccc1)n1cc(-c2ccc3nc(CN4CCNCC4)oc3c2)c2ccc(F)cc21.O=S(=O)(c1ccccc1)n1cc(I)c2ccc(F)cc21>>Fc1ccc2c(-c3ccc4nc(CN5CCNCC5)oc4c3)c[nH]c2c1",
        "output": "771"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCOC(=O)c1ccc2c(n1)CCCC2N(CCc1ccccc1O)C(=O)OC(C)(C)C.Fc1ccc(CCc2ccc(CCl)cc2)cc1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1ccc2c(n1)CCCC2N(CCc1ccccc1OCc1ccc(CCc2ccc(F)cc2)cc1)C(=O)OC(C)(C)C",
        "output": "49"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.Cc1cc(C(=O)O)cc2c1C(=O)N(Cc1ccc(OC(F)(F)F)cc1)C2.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cc(C)c2c(c1)CN(Cc1ccc(OC(F)(F)F)cc1)C2=O",
        "output": "415"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C[C@H](N)C(N)=O.CC1CCCN1c1ccc(C(=O)O)nc1OCC1CC1>>CC(C)C[C@H](NC(=O)c1ccc(N2CCCC2C)c(OCC2CC2)n1)C(N)=O",
        "output": "738"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1cc(C(=O)O)[nH]n1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.C[C@H](N)Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1.ClCCl.On1nnc2ccccc21>>CC(=O)c1cc(C(=O)N[C@@H](C)Cn2ccc(-c3ccc(C#N)c(Cl)c3)n2)[nH]n1",
        "output": "816"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCC1CN(C(=O)OC(C)(C)C)CC(OCc2ccc3ccccc3c2)C1c1ccc(Cl)cc1.CO.Cl>>CCCC1CNCC(OCc2ccc3ccccc3c2)C1c1ccc(Cl)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C(=O)O)c1cccc2cnccc12.CC(C)(C)c1ccc(CN)cc1.O=C(O)Cc1cccc2cnccc12>>CC(C(=O)NCc1ccc(C(C)(C)C)cc1)c1cccc2cnccc12",
        "output": "599"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.O.O=C1O[C@@H](COc2ccon2)CN1c1ccc(N2CCC3(CC2)OCCO3)c(F)c1>>O=C1CCN(c2ccc(N3C[C@H](COc4ccon4)OC3=O)cc2F)CC1",
        "output": "251"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1cc(C2CC2)c(-c2cc3c(cn2)cnn3C2CCCCO2)cc1F.Cl>>COc1cc(C2CC2)c(-c2cc3[nH]ncc3cn2)cc1F",
        "output": "689"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1cnc(O[C@@H]2CN3CCC2CC3)nc1.N.OB(O)c1ccc2[nH]ccc2c1>>c1cc2cc(-c3cnc(O[C@@H]4CN5CCC4CC5)nc3)ccc2[nH]1",
        "output": "871"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNC1.C1CCOC1.CS(=O)(=O)OCCCCNC(=O)OCc1ccccc1>>O=C(NCCCCN1CCCC1)OCc1ccccc1",
        "output": "496"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(O)c1cc2ncc(Cl)cn2n1.c1cncc(-c2nnc3n2CCNC3)c1>>O=C(c1cc2ncc(Cl)cn2n1)N1CCn2c(nnc2-c2cccnc2)C1",
        "output": "663"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrC(Br)(Br)Br.ClCCl.O=C(Nc1cc(Cl)cnc1N1CCC(CCCO)CC1)c1cccc(Cl)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(Nc1cc(Cl)cnc1N1CCC(CCCBr)CC1)c1cccc(Cl)c1",
        "output": "378"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C[O-].OCc1ccnc(Cl)c1.[Na+]>>COc1cc(CO)ccn1",
        "output": "433"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCc1ccc([C@H]2C[C@@H](C(F)(F)F)n3ncc(C(=O)O)c3N2)cc1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.NCc1ccc(Cl)nc1>>CCc1ccc([C@H]2C[C@@H](C(F)(F)F)n3ncc(C(=O)NCc4ccc(Cl)nc4)c3N2)cc1",
        "output": "621"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(OC)c(C)c1C.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COc1ccc(OC)c(CBr)c1C",
        "output": "29"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cccc(C(F)(F)F)c2Cl)CC1.CO.ClCCl.O=C(O)C(F)(F)F>>FC(F)(F)c1cccc(N2CCNCC2)c1Cl",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1ccc(-n2cc(CC(C)C)c3ccc(Cl)cc32)s1.[Na+].[OH-]>>CC(C)Cc1cn(-c2ccc(C(=O)O)s2)c2cc(Cl)ccc12",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=[Cr](=O)([O-])Cl.OCc1cccc2c(Br)c3ccccc3cc12.c1cc[nH+]cc1>>O=Cc1cccc2c(Br)c3ccccc3cc12",
        "output": "179"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)[C@H](Cc1cn(C)c2ccccc12)NC(=O)C=Cc1ccccc1F.[Na+].[OH-]>>Cn1cc(C[C@H](NC(=O)C=Cc2ccccc2F)C(=O)O)c2ccccc21",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1ccccc1.CCCC[N+](CCCC)(CCCC)CCCC.CO.O=C=O.OB(O)c1ccccc1.[Pd]>>c1ccc(-c2ccccc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.COc1ccc(O)c(C=O)c1.CS(=O)(=O)OCCOS(C)(=O)=O.O=C([O-])[O-].[Cs+].[Cs+]>>COc1ccc(OCCOS(C)(=O)=O)c(C=O)c1",
        "output": "702"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CS(=O)(=O)c1ccc(Br)c(Cl)c1Cl.Cc1ccccc1.O.OCCC1OCCO1.[Na+].[OH-]>>CS(=O)(=O)c1ccc(Br)c(Cl)c1OCCC1OCCO1",
        "output": "57"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(N)c1ccon1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.Cn1nc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)c2ccc(F)cc21.F[P-](F)(F)(F)(F)F.O>>CC(NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)c1ccon1",
        "output": "737"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrB(Br)Br.COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCCN(C)c1ccccc1-3.ClCCl>>CN1CCCn2c(c(C3CCCCC3)c3ccc(C(=O)O)cc32)-c2ccccc21",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClC(Cl)Cl.Nc1ccccc1CSc1nc2c([nH]1)CCCC2.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.[Na+]>>Nc1ccccc1CS(=O)c1nc2c([nH]1)CCCC2",
        "output": "595"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCCl.OCCn1cccn1>>Cc1ccc(S(=O)(=O)OCCn2cccn2)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CC2CNCC2C1.CC(C)(C)[O-].Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=c1c2ccccc2oc2ccc(I)cc12.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)OC(=O)N1CC2CN(c3ccc4oc5ccccc5c(=O)c4c3)CC2C1",
        "output": "931"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCO.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CSCC[C@H](N)c1nc2cc(Cl)ccc2[nH]1.ClBr.ClCCl.F[B-](F)(F)F.O=C(O)c1ccc(C(=O)N2CCCC2)c(Br)c1>>CSCC[C@H](NC(=O)c1ccc(C(=O)N2CCCC2)c(Br)c1)c1nc2cc(Cl)ccc2[nH]1",
        "output": "902"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN.Cc1ccc(-c2cc(C)cc3c2OC(COS(=O)(=O)c2ccc(C)cc2)C3)cc1>>CNCC1Cc2cc(C)cc(-c3ccc(C)cc3)c2O1",
        "output": "853"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COCCN.Cc1c(Cl)cccc1N1CN(C(=O)CCl)CC1=O.O=C([O-])[O-].[K+].[K+]>>COCCNCC(=O)N1CC(=O)N(c2cccc(Cl)c2C)C1",
        "output": "330"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)N1C2CCC1CC(=O)C2.CO.C[Si](C)(C)I.ClCCCl>>O=C1CC2CCC(C1)N2",
        "output": "283"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.C[C@H]1CC(=O)C[C@@H]2CC[C@H]3[C@@H]4CC[C@H](O)[C@@]4(C)CC[C@@H]3[C@@]12C.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.OCCO.c1ccncc1>>C[C@H]1CC2(C[C@@H]3CC[C@H]4[C@@H]5CC[C@H](O)[C@@]5(C)CC[C@@H]4[C@@]13C)OCCO2",
        "output": "265"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COc1ccccc1Sc1ccccc1C(=O)O.ClCCl.O=C([O-])O.O=S(=O)(O)O.[Na+]>>COC(=O)c1ccccc1Sc1ccccc1OC",
        "output": "33"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COCCN(C)C(=O)N1CCNCC1.O=Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1>>COCCN(C)C(=O)N1CCN(Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1",
        "output": "792"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCOC(C)=O.Cc1cc(/C=C/C#N)cc(C)c1N.Cl.Clc1ccnc(Cl)n1.O>>Cc1cc(/C=C/C#N)cc(C)c1Nc1ccnc(Cl)n1",
        "output": "161"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Cc1nc(Oc2ccc(C#N)cc2)ccc1CN1CCC(N2C(=O)OC[C@H]2c2ccccc2)CC1.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>Cc1nc(Oc2ccc(-c3nn[nH]n3)cc2)ccc1CN1CCC(N2C(=O)OC[C@H]2c2ccccc2)CC1",
        "output": "390"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.Cc1nc(C)c(-c2cc(C(=O)O)c(C)cc2C)[nH]1.Cl.Cl.N#Cc1ccc(C2CCNCC2)cc1.On1nnc2ccccc21>>Cc1nc(C)c(-c2cc(C(=O)N3CCC(c4ccc(C#N)cc4)CC3)c(C)cc2C)[nH]1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.ClCCl.O=C(CC1(CCO)CCCCC1)OCc1ccccc1>>O=CCC1(CC(=O)OCc2ccccc2)CCCCC1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC[C@H](C)Nc1cc(C(=O)OC)cc(CC(C)=O)n1.Cl.[Li+].[OH-]>>CC[C@H](C)Nc1cc(C(=O)O)cc(CC(C)=O)n1",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCN(c2ccc(Nc3ncc4c(=O)n5c(nc4n3)c3ccc(OCC(=O)O)cc3n5-c3ccccn3)cc2)CC1.Cl.O.O=C(O)C(F)(F)F.On1nnc2ccccc21.[Cl-].[NH4+]>>CN1CCN(c2ccc(Nc3ncc4c(=O)n5c(nc4n3)c3ccc(OCC(N)=O)cc3n5-c3ccccn3)cc2)CC1",
        "output": "313"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.Nc1cc(C(=O)O)ccc1F>>Nc1cc(CO)ccc1F",
        "output": "72"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C(=O)O)c1cccc(Cl)c1.O=S(Cl)Cl>>CC(C)(C(=O)Cl)c1cccc(Cl)c1",
        "output": "53"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)C(C)c1ncccc1Cl.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(CO)c1ncccc1Cl",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN.CN(C)C=O.Cl.ClCCl.O=C(O)CCCc1cccc2c1OC=CO2.Oc1cccc2[nH]nnc12.c1ccccc1>>CNC(=O)CCCc1cccc2c1OC=CO2",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.CCI.CO.COC(=O)/C=C/c1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>CCOc1ccc(C=CC(=O)OC)cc1",
        "output": "198"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CCC(=O)CC2)CC1.CCO.CO.N.[BH4-].[Na+]>>CC(C)(C)OC(=O)N1CCC2(CCC(N)CC2)CC1",
        "output": "63"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cn1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccc(Oc3ccc4cccc(N)c4c3)cc21.O=C=NC12CC3CC(CC(C3)C1)C2>>Cn1c(COc2ccc(CC3SC(=O)NC3=O)cc2)nc2ccc(Oc3ccc4cccc(NC(=O)NC56CC7CC(CC(C7)C5)C6)c4c3)cc21",
        "output": "176"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2nsc(Nc3ncc(Oc4ccc(C=O)cc4)cc3Sc3ccccc3Cl)n2)CC1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>O=Cc1ccc(Oc2cnc(Nc3nc(C4CCNCC4)ns3)c(Sc3ccccc3Cl)c2)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)Nc1cccc(O)c1.CN1CCC(O)CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(=O)Nc1cccc(OC2CCN(C)CC2)c1",
        "output": "846"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)C(=O)Nc1cn(C2CCCCO2)nc1-c1nc2cc(OCCCCN3CCCCC3)c(F)cc2[nH]1.ClCCl.O=C(O)C(F)(F)F>>CCN(CC)C(=O)Nc1c[nH]nc1-c1nc2cc(OCCCCN3CCCCC3)c(F)cc2[nH]1",
        "output": "689"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NCCN.CN(C)C=O.CS(=O)(=O)OCCc1ccc(C#N)cn1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)NCCNCCc1ccc(C#N)cn1",
        "output": "559"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.CC(C)=O.COc1ccc(OC)c(C(=O)Cc2cc(F)cc(F)c2)c1.ClCCl.O=C=O>>O=C(Cc1cc(F)cc(F)c1)c1cc(O)ccc1O",
        "output": "20"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cl[Sn]Cl.N#Cc1cccc(Oc2ccccc2[N+](=O)[O-])c1>>N#Cc1cccc(Oc2ccccc2N)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C=CCON=C(C(=O)OCC)c1csc(N)n1.CO.[Na+].[OH-]>>C=CCON=C(C(=O)O)c1csc(N)n1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCOC(C)=O.Clc1ccc(Oc2cccc(OCCC3CNC3)c2)cc1.O=C(Nc1cnc2cccnn12)Oc1ccccc1.O=CO>>O=C(Nc1cnc2cccnn12)N1CC(CCOc2cccc(Oc3ccc(Cl)cc3)c2)C1",
        "output": "525"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NC1CCNCC1.Cc1ccc(F)c([N+](=O)[O-])c1>>Cc1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)c([N+](=O)[O-])c1",
        "output": "26"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(NC(=O)Nc2cc(F)cc(OC3CCN(C(=O)OC(C)(C)C)C3)c2)cn1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(NC(=O)Nc2cc(F)cc(OC3CCNC3)c2)cn1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COc1cc(-c2cc3c(-c4cnc(C5(O)CCC5)s4)c(F)cnc3n2S(=O)(=O)c2ccc(C)cc2)cc(OC)c1OC.Cl.[Na+].[OH-]>>COc1cc(-c2cc3c(-c4cnc(C5(O)CCC5)s4)c(F)cnc3[nH]2)cc(OC)c1OC",
        "output": "949"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[Si](C)(C)OCc1cccc(B(O)O)c1.Cc1c(Br)cccc1CNC(=O)OC(C)(C)C.O=C([O-])[O-].[K+].[K+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1c(CNC(=O)OC(C)(C)C)cccc1-c1cccc(CO[Si](C)(C)C(C)(C)C)c1",
        "output": "908"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)c1ccncc1.ClCCl.O=C(Cl)CBr.[O-][n+]1cc(Cl)c(C[C@H](O)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1>>O=C(CBr)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1",
        "output": "126"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CN(C)CCCl.Cl.Sc1ccc(Br)cc1.[Na+].[OH-]>>CN(C)CCSc1ccc(Br)cc1",
        "output": "460"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cccnc1N1CCN(Cc2ccccc2)CC1.[Al+3].[H-].[H-].[H-].[H-].[K+].[Li+].[OH-]>>OCc1cccnc1N1CCN(Cc2ccccc2)CC1",
        "output": "383"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.Nc1cccc2c1ccn2S(=O)(=O)c1ccccc1.O.O=C(Br)CBr.O=C([O-])O.[Na+]>>O=C(CBr)Nc1cccc2c1ccn2S(=O)(=O)c1ccccc1",
        "output": "442"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCN)CC1.Cc1ccc(C=O)cc1>>COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCNCc2ccc(C)cc2)CC1",
        "output": "468"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CNc1c(C(=O)OC)cc(-c2c(C)noc2C)cc1[N+](=O)[O-].[Na+].[OH-]>>CNc1c(N)cc(-c2c(C)noc2C)cc1C(=O)OC",
        "output": "481"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "FC(F)(F)c1cc(Cl)nc(-c2cnccn2)n1.Nc1cc(O)ccc1Cl>>Oc1ccc(Cl)c(Nc2cc(C(F)(F)F)nc(-c3cnccn3)n2)c1",
        "output": "161"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)Nc1c([N+](=O)[O-])cnc2ccccc12.CCOC(C)=O.O=S(=O)([O-])[O-].[H][H].[Mg+2].[Pt]>>CC(C)(C)Nc1c(N)cnc2ccccc12",
        "output": "269"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)Cc1ccc([N+](=O)[O-])cn1.[Pd]>>COC(=O)Cc1ccc(N)cn1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=C[C@@H]1C[C@]1(N)C(=O)NS(=O)(=O)c1ccccc1NC(=O)CCCCCCC(=O)OC.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1ccc2c(O[C@@H]3C[C@@H](C(=O)O)N(C(=O)OC(C)(C)C)C3)cc(-c3ccccc3)nc2c1.F[P-](F)(F)(F)(F)F>>C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2cc(-c3ccccc3)nc3cc(OC)ccc23)CN1C(=O)OC(C)(C)C)C(=O)NS(=O)(=O)c1ccccc1NC(=O)CCCCCCC(=O)OC",
        "output": "131"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cl.NN.O.O=C1c2ccccc2C(=O)N1C1CCN(Cc2ccc(F)cc2)CC1>>NC1CCN(Cc2ccc(F)cc2)CC1",
        "output": "242"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COc1ccc(CNc2nc(Br)cnc2NC(=O)c2c(Cl)c(C(C)(C)C)nn2C)cc1.Cc1ccccc1.ClCCl.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccccc1C(F)(F)F.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1ccc(CNc2nc(-c3ccccc3C(F)(F)F)cnc2NC(=O)c2c(Cl)c(C(C)(C)C)nn2C)cc1",
        "output": "876"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.C[Si](C)(C)C#Cc1cccc(OC(F)(F)F)c1.Cl.O=C([O-])[O-].[K+].[K+]>>C#Cc1cccc(OC(F)(F)F)c1",
        "output": "337"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)COc1ccc(S(C)(=O)=O)cc1C(=O)O.CCOC(C)=O.Cl.c1ccc2nc(N3CCNCC3)cnc2c1>>CC(C)COc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2cnc3ccccc3n2)CC1",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.BrBr.CC(=O)O.CC(=O)c1ccc(NS(C)(=O)=O)cn1.CCOCC>>CS(=O)(=O)Nc1ccc(C(=O)CBr)nc1",
        "output": "173"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCc1ccccc1.CC(C)=O.COc1c(C)c(Cc2cccc(O)c2C=O)c(OC)c(OC)c1OC.O=C([O-])[O-].[Na+].[Na+]>>COc1c(C)c(Cc2cccc(OCc3ccccc3)c2C=O)c(OC)c(OC)c1OC",
        "output": "127"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOc1cc(Oc2ccc(NS(=O)(=O)c3ccc(C)cc3)c(C(=O)OC)c2)ccc1[N+](=O)[O-].CO.O.[Cl-].[Fe].[NH4+]>>CCOc1cc(Oc2ccc(NS(=O)(=O)c3ccc(C)cc3)c(C(=O)OC)c2)ccc1N",
        "output": "335"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CNCC(C)C1.CCOC(=O)C1=Cc2cc(Cl)c(F)cc2OC1C(F)(F)F.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C1=Cc2cc(Cl)c(N3CC(C)CC(C)C3)cc2OC1C(F)(F)F",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)CCCNc1nc(NC2CCN(C(=O)OC(C)(C)C)CC2)c2ccccc2n1.CO.ClCCl.N.O=C(O)C(F)(F)F>>CN(C)CCCNc1nc(NC2CCNCC2)c2ccccc2n1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)CCNC1.COC[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1ccc(F)cc1)C2>>COC[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1ccc(N3CCC(C)(C)C3)cc1)C2",
        "output": "26"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1cccc(C(=O)O)c1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc(N)cc1Br.F[P-](F)(F)(F)(F)F.[Na+].[OH-]>>Cc1ccc(NC(=O)c2cccc(C(C)(C)C)c2)cc1Br",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC2(CCC(OCc3ccccc3)CC2)C1.CO.[H][H].[OH-].[OH-].[Pd+2]>>CC(C)(C)OC(=O)N1CC2(CCC(O)CC2)C1",
        "output": "178"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(OCCc2c(CCNS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1F.CO.[Na+].[OH-]>>O=C(O)c1ccc(OCCc2c(CCNS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1F",
        "output": "386"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC=C(C(=O)OC)c1ccccc1CBr.O=C(O)c1ccccc1.[K+].[OH-]>>COC=C(C(=O)OC)c1ccccc1COC(=O)c1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCCBr.CC(C)c1nc(I)c(I)[nH]1.CN(C)C=O.O.[H-].[Na+]>>CC(C)c1nc(I)c(I)n1CCNC(=O)OC(C)(C)C",
        "output": "276"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.ClI.Nc1ccc(-c2nc3ccccc3o2)cc1>>Nc1ccc(-c2nc3ccccc3o2)cc1I",
        "output": "466"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(C)=O.Cl.O.O=C(O)c1cnc(Cl)c(Br)c1.OCC(F)(F)F.[K+].[OH-]>>O=C(O)c1cnc(OCC(F)(F)F)c(Br)c1",
        "output": "433"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1.O=C(O)C[C@@H]1CCCO1>>O=C(C[C@@H]1CCCO1)N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNC1.C1CCOC1.CC(=O)O.ClCCl.O=CCc1cnc2cc(Br)cnc2c1>>Brc1cnc2cc(CCN3CCCC3)cnc2c1",
        "output": "484"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(CCc1ccc([N+](=O)[O-])cc1)CCn1ncc2ccccc2c1=O.Cl.Cl.[Na+].[OH-]>>CN(CCc1ccc(N)cc1)CCn1ncc2ccccc2c1=O",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.CC1CCc2c(N)c(Cl)cc3c(=O)c(C(=O)O)cn1c23>>CC(=O)Nc1c(Cl)cc2c(=O)c(C(=O)O)cn3c2c1CCC3C",
        "output": "6"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1[nH]cc2c1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2.O=C([O-])[O-].O=P(Cl)(Cl)Cl.[Na+].[Na+]>>Cc1[nH]c(C=O)c2c1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2",
        "output": "641"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(C)=O.NCCN1CCOCC1.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c(Br)c1.[K+].[K+]>>O=[N+]([O-])c1ccc(NCCN2CCOCC2)c(Br)c1",
        "output": "572"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)Cc1ccc(-c2nc3ccccc3c(-c3ccccc3)c2Cl)s1.[Na+].[OH-]>>O=C(O)Cc1ccc(-c2nc3ccccc3c(-c3ccccc3)c2Cl)s1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(Cc2nc3c4ccc5c(c4nc(N)n3n2)OC(F)(F)O5)C1.Cl.ClCCl>>Nc1nc2c3c(ccc2c2nc(CC4CCNC4)nn12)OC(F)(F)O3",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COCOc1c(C)c(C=CC=CCO)c(OCOC)c(OC)c1OC.ClCCl>>COCOc1c(C)c(C=CC=CC=O)c(OCOC)c(OC)c1OC",
        "output": "183"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.Nc1ccc(Br)cc1.Nc1ccc(Br)cc1[N+](=O)[O-].O=[N+]([O-])O>>CC(=O)Nc1ccc(Br)cc1[N+](=O)[O-]",
        "output": "6"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN1CCC(CCO)C1=O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CN1CCC(CCO)C1",
        "output": "112"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cccc(C(F)(F)COCCCCCCN2C(=O)c3ccccc3C2=O)c1.NCCCCCCOCC(F)(F)c1ccccc1>>Cc1cccc(C(F)(F)COCCCCCCN)c1",
        "output": "242"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[Si](C)(C)Oc1cc(O)cc(O[Si](C)(C)C(C)(C)C)c1.CCCCP(CCCC)CCCC.CCOC(C)=O.CN(C)C(=O)N=NC(=O)N(C)C.Cc1ccccc1.OCCOCCOCCOCCOCCOC(c1ccccc1)(c1ccccc1)c1ccccc1>>CC(C)(C)[Si](C)(C)Oc1cc(OCCOCCOCCOCCOCCOC(c2ccccc2)(c2ccccc2)c2ccccc2)cc(O[Si](C)(C)C(C)(C)C)c1",
        "output": "478"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1cnc(Oc2cc3ccccc3cn2)c(Cl)c1>>Nc1cnc(Oc2cc3ccccc3cn2)c(Cl)c1",
        "output": "269"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)C(C#N)=NOC(N(C)C)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.NCC1CCN(c2ccncc2)CC1.O=C(O)c1cccc(OCCc2ccc(Cl)cc2Cl)c1>>O=C(NCC1CCN(c2ccncc2)CC1)c1cccc(OCCc2ccc(Cl)cc2Cl)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Fc1ccc(/C=C/c2nc(CCl)co2)c(F)c1.OCC(O)Cc1nccn1CCCc1cccc(O)c1.[H-].[Na+]>>OCC(O)Cc1nccn1CCCc1cccc(OCc2coc(/C=C/c3ccc(F)cc3F)n2)c1",
        "output": "760"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)OB(c2cnn(C3CCNCC3)c2)OC1(C)C.CCN(CC)CC.CS(=O)(=O)Cl.Cl.ClCCl>>CC1(C)OB(c2cnn(C3CCN(S(C)(=O)=O)CC3)c2)OC1(C)C",
        "output": "584"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc2c(Cl)cn(CC(=O)OC(C)(C)C)c2c1.[Li+].[OH-]>>Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc2c(Cl)cn(CC(=O)O)c2c1",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Nc1c(-c2cccnc2)cncc1[N+](=O)[O-].[Pd]>>Nc1cncc(-c2cccnc2)c1N",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1ccc2c(c1)CCC2=O.CON.Cl.c1ccncc1>>CON=C1CCc2cc(C(C)(C)C)ccc21",
        "output": "212"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1cccc(N)c1.Cc1ccccc1.O=CCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CCc1cccc(NCCCc2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)c1",
        "output": "336"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.COc1ccc(Br)cn1.O=C(O)c1ccc(B(O)O)cc1.O=C([O-])[O-].[Na+].[Na+]>>COc1ccc(-c2ccc(C(=O)O)cc2)cn1",
        "output": "833"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.C[C@@H](CO[Si](C)(C)C(C)(C)C)NC(=O)c1csc(N2CC(O)C2)n1.ClCCl>>C[C@@H](CO[Si](C)(C)C(C)(C)C)NC(=O)c1csc(N2CC(OS(C)(=O)=O)C2)n1",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)C1(C)CCC(Oc2ccc(NC(=O)c3nnc(Nc4ccc(Cl)cc4Cl)o3)cn2)CC1.C[Si](C)(C)[O-].[K+]>>CC1(C(=O)O)CCC(Oc2ccc(NC(=O)c3nnc(Nc4ccc(Cl)cc4Cl)o3)cn2)CC1",
        "output": "281"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1ccc(N2CCN(Cc3ccccc3)CC2CO)cc1.CS(=O)(=O)Cl.O.c1ccncc1>>CC(C)c1ccc(N2CCN(Cc3ccccc3)CC2COS(C)(=O)=O)cc1",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.OCCCc1ccccc1.[Na+]>>COc1cc2nccc(Oc3ccc(NC(=O)OCCCc4ccccc4)cc3)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1-c1ccccc1.CN(C)C=O.COc1nccc2[nH]c(C)cc12>>COc1nccc2c1cc(C)n2Cc1ccccc1-c1ccccc1",
        "output": "528"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1ccc(C(F)(F)F)cc1O.OCc1ccc(Cl)cc1O>>OCc1ccc(C(F)(F)F)cc1O",
        "output": "444"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CO.COc1cc2c(c(C)c1C)N(CCN=[N+]=[N-])CC1(CCC1)C2.[Pd]>>COc1cc2c(c(C)c1C)N(CCN)CC1(CCC1)C2",
        "output": "89"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COC(C)(C)C.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.NC(=O)CCSc1ccc(Br)cc1C(F)(F)F.O.O=C([O-])[O-].[K+].[K+]>>Cn1cc(-c2ccc(SCCC(N)=O)c(C(F)(F)F)c2)cn1",
        "output": "971"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CI.CN(C)C=O.COc1ccc(-n2nc(C(C)(C)O)cc2-c2ccc(OCCO[Si](C)(C)C(C)(C)C)cc2)cc1.[H-].[Na+]>>COc1ccc(-n2nc(C(C)(C)OC)cc2-c2ccc(OCCO[Si](C)(C)C(C)(C)C)cc2)cc1",
        "output": "140"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.NN.O.O=C1COc2c(cc(Cl)cc2N2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2)N1>>NCCCCN1CCN(c2cc(Cl)cc3c2OCC(=O)N3)CC1",
        "output": "242"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)CCCCCCCC(=O)CCCCc1ccccc1.COC([O-])[O-].Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.OCCO>>COC(=O)CCCCCCCC1(CCCCc2ccccc2)OCCO1",
        "output": "265"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCOCCOCCOCCOCCO1.CC1(C)Oc2ccc(O)cc2O1.CN(C)C=O.ClC(Cl)=CCOc1cc(Cl)c(OCCCCBr)c(Cl)c1.O=C([O-])[O-].[K+].[K+]>>CC1(C)Oc2ccc(OCCCCOc3c(Cl)cc(OCC=C(Cl)Cl)cc3Cl)cc2O1",
        "output": "75"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.Cc1cc(-c2ncnc3c(C(=O)N[C@@H]4CCNC[C@H]4O)c(C)[nH]c23)c(OCC2CC2)cc1F.Cl>>CC(=O)N1CC[C@@H](NC(=O)c2c(C)[nH]c3c(-c4cc(C)c(F)cc4OCC4CC4)ncnc23)[C@H](O)C1",
        "output": "125"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COc1cnc(-c2n[nH]c3ccccc23)nc1Nc1ccncc1.Cc1ccc(Cl)c(CBr)c1F.[H-].[Na+]>>COc1cnc(-c2nn(Cc3c(Cl)ccc(C)c3F)c3ccccc23)nc1Nc1ccncc1",
        "output": "635"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)C(=O)Cl.CC[O-].CN1CCC(c2c[nH]c3ccc(N)cc23)CC1.Cl.Cl>>CN1CCC(c2c[nH]c3ccc(NC(=O)C(C)(C)C)cc23)CC1",
        "output": "9"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)/C(C)=C/[C@@H](C(C)C)N(C)C(=O)[C@@H](N)C(C)(C)SCc1ccc(OC)cc1.CN(C(=O)OC(C)(C)C)[C@H](C(=O)O)C(C)(C)c1ccccc1.ClCCl.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CCOC(=O)/C(C)=C/[C@@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](N(C)C(=O)OC(C)(C)C)C(C)(C)c1ccccc1)C(C)(C)SCc1ccc(OC)cc1",
        "output": "133"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCC(N)CC2)n1.ClCCl.O=C([O-])[O-].O=S(=O)(Cl)CCl.[K+].[K+]>>COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCC(NS(=O)(=O)CCl)CC2)n1",
        "output": "493"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1.O.O=C(O)C(F)(F)F.O=C(O)C1CCN(C(=O)CCc2ccccc2)CC1.On1nnc2ccccc21>>O=C(NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1)C1CCN(C(=O)CCc2ccccc2)CC1",
        "output": "133"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.C[C@H](N)c1nn2ccc(Br)c2c(=O)n1-c1ccccc1.Nc1ncnc(Cl)c1I.[Cs+].[F-]>>C[C@H](Nc1ncnc(N)c1I)c1nn2ccc(Br)c2c(=O)n1-c1ccccc1",
        "output": "110"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1C[C@@H](CCl)c2c1cc(O)c1ccccc21.CCN(CC)CC.CN(C)c1ccncc1.CN1CCN(C(=O)Cl)CC1.Cl.ClCCl>>CN1CCN(C(=O)Oc2cc3c(c4ccccc24)[C@H](CCl)CN3C(=O)OC(C)(C)C)CC1",
        "output": "425"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)C[C@@H](CCCC1CCCCC1)c1nc(C(=O)N2CCOCC2)no1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)C[C@@H](CCCC1CCCCC1)c1nc(C(=O)N2CCOCC2)no1",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CO.COCCBr.Cc1ccc(S(=O)(=O)O)cc1.Cl.ClCCl.N.[N-]=[N+]=N[C@@H]1CNC[C@H]1O>>COCCN1C[C@@H](O)[C@H](N=[N+]=[N-])C1",
        "output": "73"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCCN(C)C.CCSc1ccccc1C(=O)O.Cl.Nc1ccc(C(F)(F)F)cn1.O=C([O-])O.On1nnc2ccccc21.[Na+].c1ccncc1>>CCSc1ccccc1C(=O)Nc1ccc(C(F)(F)F)cn1",
        "output": "744"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.CN(C)C=O.O=C1NC(=O)c2ccccc21.O=S1(=O)CCC(CO)CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C1c2ccccc2C(=O)N1CC1CCS(=O)(=O)CC1",
        "output": "420"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.COCOc1ccc(-c2nc3cc(OC)cc(OC)c3c(=O)[nH]2)cc1CCO.O.O=S(=O)(O)O>>COc1cc(OC)c2c(=O)[nH]c(-c3ccc(O)c(CCO)c3)nc2c1",
        "output": "755"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)O.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc(C(F)(F)F)cc1.O=C=O>>CC(C)(C)OC(=O)Nc1ccc(C(F)(F)F)cc1",
        "output": "735"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(CC(O)(CO)C(F)(F)F)c1ccccc1.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCC(O)(CC(C)c2ccccc2)C(F)(F)F)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cc1cccc(C=O)c1.CO.Cc1ccc(CN)cc1.O=C([O-])O.[BH4-].[Na+].[Na+]>>CCOC(=O)Cc1cccc(CNCc2ccc(C)cc2)c1",
        "output": "683"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.O=C1CCC(=O)N1Br.c1ccc2c(c1)c1ccccc1c1cc(-n3c4ccccc4c4ccccc43)ccc21>>Brc1ccc2c(c1)c1ccccc1n2-c1ccc2c3ccccc3c3ccccc3c2c1",
        "output": "4"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)CNC(=O)c1c(O)c2ccc(C)cc2oc1=O.CO.O.[Na+].[OH-]>>Cc1ccc2c(O)c(C(=O)NCC(=O)O)c(=O)oc2c1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)C(OCC)C(=O)NCc1ccc(C#N)cc1.CO.O.[Li+].[OH-]>>CCOC(C(=O)O)C(=O)NCc1ccc(C#N)cc1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=P(Cl)(Cl)Cl.[O-][n+]1cc(-c2ccccc2)c2ccccc2c1>>Clc1ncc(-c2ccccc2)c2ccccc12",
        "output": "2"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1NCCc2cc(F)ccc21.O=C(O)c1cc2ncc(Cl)cn2n1>>CN1c2ccc(F)cc2CCN1C(=O)c1cc2ncc(Cl)cn2n1",
        "output": "995"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.N#Cc1cccc(CC(=O)O)c1.O=S(=O)(O)O>>COC(=O)Cc1cccc(C#N)c1",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Nc2ccc(C(=O)c3ccccc3F)c(N)n2)CC1.ClCCl.O=C(O)C(F)(F)F>>Nc1nc(NC2CCNCC2)ccc1C(=O)c1ccccc1F",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.CN1CCN(c2cccc(C3Nc4ccc(C(=O)O)cc4CC3(C)C)c2)CC1.CS(N)(=O)=O.O=C(n1ccnc1)n1ccnc1.[H-].[Na+]>>CN1CCN(c2cccc(C3Nc4ccc(C(=O)NS(C)(=O)=O)cc4CC3(C)C)c2)CC1",
        "output": "580"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O=C(O)CCCOCc1ccccc1.O=S(=O)(O)O>>COC(=O)CCCOCc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCc1cc([N+](=O)[O-])c(C(C)=O)cc1OC.N.O.[Fe]>>CCc1cc(N)c(C(C)=O)cc1OC",
        "output": "202"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.Cc1cc(C(=O)O)cnc1F.Cl.O.OCC(F)(F)F.[H-].[Na+]>>Cc1cc(C(=O)O)cnc1OCC(F)(F)F",
        "output": "541"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCOC(C)=O.CCc1ccc(C(=O)O)cc1OC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)c1ccc2c(c1)OC1(CCNCC1)c1cccn1-2.F[P-](F)(F)(F)(F)F>>CCc1ccc(C(=O)N2CCC3(CC2)Oc2cc(C(=O)OC)ccc2-n2cccc23)cc1OC",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClC(Cl)Cl.Cn1ncc(C(=O)O)c1N.NCCNC(c1ccccc1)(c1ccccc1)c1ccccc1>>Cn1ncc(C(=O)NCCNC(c2ccccc2)(c2ccccc2)c2ccccc2)c1N",
        "output": "621"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)N1CCNCC1.CN(C)C=O.ClCc1cc(Cl)ccc1Cl.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)N1CCN(Cc2cc(Cl)ccc2Cl)CC1",
        "output": "156"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)O.CCc1c(CN2CC(C(=O)OC)C2)cccc1-c1nnc(-c2ccc(OC(C)C)c(Cl)c2)s1.Cl.O.[Na+].[OH-]>>CCc1c(CN2CC(C(=O)O)C2)cccc1-c1nnc(-c2ccc(OC(C)C)c(Cl)c2)s1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1cc(C=CC(=O)c2ccccc2)cc(C(F)(F)F)c1O.Cl.ClCCl.ClCCl>>O=C(C=Cc1cc(O)c(O)c(C(F)(F)F)c1)c1ccccc1",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)CNC(=O)C1=C(O)c2ccc(Cl)c(Cl)c2C(C)(C)C1=O.O=C(O)C(F)(F)F>>CC1(C)C(=O)C(C(=O)NCC(=O)O)=C(O)c2ccc(Cl)c(Cl)c21",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C[AlH]CC(C)C.COC(=O)c1ccc(OC(F)F)nc1.Cc1ccccc1.O.O=C([O-])O.[Na+].[Na+].[OH-]>>OCc1ccc(OC(F)F)nc1",
        "output": "522"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)C(=O)c1ccc(OCCOc2ccc3ccccc3c2)c(C)c1.O.[Na+].[OH-]>>Cc1cc(C(=O)C(=O)O)ccc1OCCOc1ccc2ccccc2c1",
        "output": "506"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CN[C@H](CN2CCOCC2)C1.CCO.CCOC(C)=O.CO.O=C1Nc2cccnc2N(C(=O)CCl)c2ccccc21>>O=C1Nc2cccnc2N(C(=O)CN2CCC[C@H]2CN2CCOCC2)c2ccccc21",
        "output": "340"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)C(C)(C)NC(=O)c1ccc2ccccc2c1CCCCc1ccccc1.Cl.[Na+].[OH-]>>CC(C)(NC(=O)c1ccc2ccccc2c1CCCCc1ccccc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCN=C=O.CCN(CC)CC.Cl.ClCCCl.O.c1ccc(-c2ccc(-c3c[nH]c(C4CCNCC4)n3)cc2)cc1>>CCCCNC(=O)N1CCC(c2nc(-c3ccc(-c4ccccc4)cc3)c[nH]2)CC1",
        "output": "437"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(N=C=O)cc1C(F)(F)F.NC(=O)c1[nH]c2ncccc2c1-c1ccc(N)cc1>>Cc1ccc(NC(=O)Nc2ccc(-c3c(C(N)=O)[nH]c4ncccc34)cc2)cc1C(F)(F)F",
        "output": "473"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCOC(C)=O.CO.CO.COC(=O)c1ccc(F)c2c1CC(N)CO2.O=CCCc1c[nH]c2ccc(F)cc12.[BH3-]C#N.[Na+]>>COC(=O)c1ccc(F)c2c1CC(NCCCc1c[nH]c3ccc(F)cc13)CO2",
        "output": "426"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(c1cc(N)cc(Br)c1)c1cccc(OC(F)F)c1.CC(C)Oc1cc(CN2CCOCC2)cc(C(C)(C)c2cc(Cl)cc([N+](=O)[O-])c2)c1>>CC(C)Oc1cc(CN2CCOCC2)cc(C(C)(C)c2cc(N)cc(Cl)c2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.Cc1cc(NC(=O)NCCN2CCNCC2)c2ccccc2n1.O=C=Nc1ccccc1-c1ccccc1>>Cc1cc(NC(=O)NCCN2CCN(C(=O)Nc3ccccc3-c3ccccc3)CC2)c2ccccc2n1",
        "output": "323"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)[C@@H](Cc1ccccc1)C[C@H](Cc1ccccc1)C(=O)Cl.NCCC(=O)O.O.O=C([O-])[O-].[Na+].[Na+]>>CCOC(=O)[C@@H](Cc1ccccc1)C[C@H](Cc1ccccc1)C(=O)NCCC(=O)O",
        "output": "45"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrBr.CC(=O)O.Cc1cccc(NC(=O)c2ccccc2C)c1>>Cc1cc(NC(=O)c2ccccc2C)ccc1Br",
        "output": "98"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCl.FC(F)c1nc(-c2n[nH]c3c2CNCC3)cs1.O=C(Nc1cccc(Cl)c1)Oc1ccccc1>>O=C(Nc1cccc(Cl)c1)N1CCc2[nH]nc(-c3csc(C(F)F)n3)c2C1",
        "output": "525"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CCN(C(C)C)C(C)C.CN(C)C=O.Cl.ClCCN(Cc1ccccc1)Cc1ccccc1.NCCF.[Br-]>>FCCNCCN(Cc1ccccc1)Cc1ccccc1",
        "output": "279"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1ccccc1-c1nc2c(c(=O)n1CCc1ccccc1Cl)CCCC2.ClCCl.O=C([O-])O.[Na+]>>O=c1c2c(nc(-c3ccccc3O)n1CCc1ccccc1Cl)CCCC2",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CC=C(c2cccc(-c3ccccc3)c2)CC1.ClCCl.O=C(O)C(F)(F)F>>N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CC=C(c2cccc(-c3ccccc3)c2)CC1",
        "output": "431"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCC1CCCN(Cc2ccccc2)C1.CO.[Pd]>>CC(C)(C)OC(=O)NCC1CCCNC1",
        "output": "84"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCN1CCNCC1.CN(C)C(ON1C(=O)CCC1=O)=[N+](C)C.CN(C)C=O.COc1ccc(-c2ccnc3[nH]c(-c4ccc(C(=O)O)cc4)nc23)cc1.F[B-](F)(F)F>>CCN1CCN(C(=O)c2ccc(-c3nc4c(-c5ccc(OC)cc5)ccnc4[nH]3)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCNc1nc(F)ccc1[N+](=O)[O-].[OH-].[OH-].[Pd+2]>>CCNc1nc(F)ccc1N",
        "output": "269"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=S(=O)(c1ccccc1)c1ccc(O)cc1.c1ccncc1>>O=S(=O)(c1ccccc1)c1ccc(OS(=O)(=O)C(F)(F)F)cc1",
        "output": "731"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC1)CC(=O)C2.CCO.Cl.NO.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCC2(CC1)CC(=NO)C2",
        "output": "86"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "B.C1CCOC1.CCN(CC)C(=O)Cc1ccc([N+](=O)[O-])cc1Cl>>CCN(CC)CCc1ccc([N+](=O)[O-])cc1Cl",
        "output": "112"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)COc1ccc(F)c2nc(C(C)C)c(Cc3ccc(-n4cccn4)cc3)c(C)c12.Cl.O.[Li+].[OH-]>>Cc1c(Cc2ccc(-n3cccn3)cc2)c(C(C)C)nc2c(F)ccc(OCC(=O)O)c12",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1cnc(Nc2ccc3c(c2)OCCO3)nc1Nc1ccc2c(c1)OCCO2.CCOC(C)=O.COCCOC.OB(O)c1ccccc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>c1ccc(-c2cnc(Nc3ccc4c(c3)OCCO4)nc2Nc2ccc3c(c2)OCCO3)cc1",
        "output": "871"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CNC.Nc1nc2cc(F)ccc2[n+]([O-])n1>>CN(C)c1ccc2c(c1)nc(N)n[n+]2[O-]",
        "output": "676"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)Oc1cc(Cc2ccccn2)ccc1CCCO.CCCCP(CCCC)CCCC.COC(=O)Cc1cccc(OC)c1O.Cl.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.OCC1CCCO1.[Na+].[OH-]>>COc1cccc(CC(=O)O)c1OCCCc1ccc(Cc2ccccn2)cc1OC(C)C",
        "output": "928"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COc1cc([N+](=O)[O-])c2ncccc2c1.NN.O.[Ni]>>COc1cc(N)c2ncccc2c1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.CS(C)=O.Cc1cc(Cl)nc(N2CC[C@@H](F)C2)c1[N+](=O)[O-]>>Cc1cc(N2CCOCC2)nc(N2CC[C@@H](F)C2)c1[N+](=O)[O-]",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)[C@@H]1CCN(C(=O)C2CNC2)C1.F[P-](F)(F)(F)(F)F.O=Cc1ccc(F)c(C(=O)O)c1>>CN(C)[C@@H]1CCN(C(=O)C2CN(C(=O)c3cc(C=O)ccc3F)C2)C1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCO.NCCCCO.O=[Pt]=O>>CC(C)NCCCCO",
        "output": "236"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCNc1c(OC)nc2c(c1Cl)C(C)CN(C(=O)C(F)(F)F)CC2.CO.O.O=C([O-])[O-].[K+].[K+]>>CCNc1c(OC)nc2c(c1Cl)C(C)CNCC2",
        "output": "703"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)C(O)c1ccc(C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)C(O)c1ccc(C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NCCOCCOCCN.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)C=Cc1ccc(OCC(=O)O)c(OC)c1.O=C1CCC(=O)N1O>>COC(=O)C=Cc1ccc(OCC(=O)NCCOCCOCCNC(=O)OC(C)(C)C)c(OC)c1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(Cc1ccc(OCCc2ccc(OS(C)(=O)=O)cc2)c(Cc2ccccc2)c1)C(=O)[O-].O.[Li+].[OH-]>>CCOC(Cc1ccc(OCCc2ccc(OS(C)(=O)=O)cc2)c(Cc2ccccc2)c1)C(=O)O",
        "output": "151"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(=NOCSC)c1csc(NC=O)n1.CO.Cl.[OH-]>>CSCON=C(C(=O)O)c1csc(NC=O)n1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.COC(=O)C(CC1CCOCC1)c1ccc(S(C)(=O)=O)c(C)c1.O.O.O=S(=O)([O-])O.[K+].[Li+].[OH-]>>Cc1cc(C(CC2CCOCC2)C(=O)O)ccc1S(C)(=O)=O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cccc(CNC(=O)C(C)(C)CO)c1.N#Cc1c(N)cccc1F>>COc1cccc(CNC(=O)C(C)(C)COc2cccc(N)c2C#N)c1",
        "output": "485"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)N=C=NC(C)C.Cl.N#Cc1ccc2c(c1)cc(C(=O)O)n2Cc1cccc(OC(F)(F)F)c1.N[C@H]1CC[C@H](O)CC1>>N#Cc1ccc2c(c1)cc(C(=O)N[C@@H]1CC[C@@H](O)CC1)n2Cc1cccc(OC(F)(F)F)c1",
        "output": "137"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CNCCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1.CO.COC(=O)CCCCCNC(N)=S.Cl.Cl.O=C([O-])O.[Na+].[Na+].[OH-]>>CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)CCCCCNC(N)=S",
        "output": "227"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cccc(C)c1.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)cc1Cl.Oc1ccc(Cl)cc1Cl.[K+].[K+]>>O=[N+]([O-])c1ccc(Cl)cc1Oc1ccc(Cl)cc1Cl",
        "output": "299"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(O)CC1.C[Si](C)(C)[N-][Si](C)(C)C.Cc1c(Cl)ncnc1Cl.[Na+]>>Cc1c(Cl)ncnc1OC1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "653"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCOC(C)=O.O=P(Cl)(Cl)Cl.O=[N+]([O-])c1cncnc1O>>O=[N+]([O-])c1cncnc1Cl",
        "output": "25"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Nc1cc(-c2cccs2)n[nH]1.O=C1CCC(=O)N1Br>>Nc1[nH]nc(-c2cccs2)c1Br",
        "output": "620"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.CN(C)c1ccccn1.CN1CCOCC1.Cl.ClCCl.NCCc1ccccc1>>CC(C)(C)OC(=O)NCCc1ccccc1",
        "output": "631"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(C)C=O.Cl.OC1(c2cc3nc(Cl)nc(N4CCOCC4)c3s2)CCNCC1.[Na+]>>CN1CCC(O)(c2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1",
        "output": "217"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C(O)c1cccc2c1-c1ccccc1C2=O.O=S(Cl)Cl>>O=C(Cl)c1cccc2c1-c1ccccc1C2=O",
        "output": "3"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)OC(=O)N=NC(=O)OC(C)C.CN(C)C=O.CNC(=O)c1ccc(O)cn1.OCCCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CNC(=O)c1ccc(OCCCO)cn1",
        "output": "547"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CN(C)C=O.CN1CCCC1=O.N#CC1(c2cccc(C(=O)O)c2)CC1.Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c(Cl)cc1F.O=C(Cl)C(=O)Cl>>N#CC1(c2cccc(C(=O)Nc3cc(Oc4ccc5nc(NC(=O)C6CC6)cn5n4)c(Cl)cc3F)c2)CC1",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CCNC1.CC(C)NC(C)C.CN(C)C=O.O.O=[N+]([O-])c1cccc(CCl)c1>>CC(C)(C)OC(=O)N[C@@H]1CCN(Cc2cccc([N+](=O)[O-])c2)C1",
        "output": "156"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCC(F)(F)F.O=C(O)c1ccc2cncc(Br)c2n1>>O=C(NCC(F)(F)F)c1ccc2cncc(Br)c2n1",
        "output": "137"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COCCOCCOC.COc1cc2nccc(Cl)c2cc1OC.Cc1ccc(O)c(C)c1.[Na+].[OH-]>>COc1cc2nccc(Oc3ccc(C)cc3C)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(Cl)Cl.CCCC[N+](CCCC)(CCCC)CCCC.ClCCl.O.O=[N+]([O-])O.Oc1ccc(F)c(F)c1.[Br-]>>O=[N+]([O-])c1cc(F)c(F)cc1O",
        "output": "21"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NC1CCNCC1.CC(C)(C)c1nc2cc(C(=O)O)ccc2n1CC1CCC(F)(F)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F>>CC(C)(C)OC(=O)NC1CCN(C(=O)c2ccc3c(c2)nc(C(C)(C)C)n3CC2CCC(F)(F)CC2)CC1",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCO.CN(C)CCCl.Cc1c(O)cccc1[N+](=O)[O-].Cl.O.O=C([O-])[O-].[K+].[K+]>>Cc1c(OCCN(C)C)cccc1[N+](=O)[O-]",
        "output": "74"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)c1cnc(C(=O)O)nc1.CCN(CC)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.N[C@H]1CCN(c2nccn3cnnc23)C1>>CC(C)c1cnc(C(=O)N[C@H]2CCN(c3nccn4cnnc34)C2)nc1",
        "output": "951"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)Cc1ccccc1OCc1coc(CCc2nc(-c3ccccc3)oc2C)n1.Cl.O.[Na+].[OH-]>>Cc1oc(-c2ccccc2)nc1CCc1nc(COc2ccccc2CC(=O)O)co1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Brc1c[nH]cn1.Cc1cc(-c2ccc(Cl)cc2)nc(Cl)n1>>Cc1cc(-c2ccc(Cl)cc2)nc(-n2cnc(Br)c2)n1",
        "output": "788"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CCN.CN(C)C=O.CN(C)CCCN=C=N.Cc1cc(C(=O)O)[nH]c1C=O.Cl.On1nnc2ccccc21>>CCN(CC)CCNC(=O)c1cc(C)c(C=O)[nH]1",
        "output": "137"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.O.O=C(c1ccoc1)c1ccc2[nH]c(=O)cc(-c3cccc(Cl)c3)c2c1.[H-].[Na+]>>Cn1c(=O)cc(-c2cccc(Cl)c2)c2cc(C(=O)c3ccoc3)ccc21",
        "output": "191"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CNCCc1cccc(CC(=O)OC)c1.COc1ccc(C(C#N)(CCCBr)C(C)C)cc1OC>>COC(=O)Cc1cccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)c1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(N3CCNCC3)cn2)c2ccccc21.CCN(CC)CC.ClCCl.O=S(=O)(Cl)C1CC1>>CC(C)(C)OC(=O)N1CCN(c2ccc(N3CCN(S(=O)(=O)C4CC4)CC3)cn2)c2ccccc21",
        "output": "584"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)COC(=O)[C@H](C)N.O=C(O)Cc1ccsc1>>CC(C)COC(=O)[C@H](C)NC(=O)Cc1ccsc1",
        "output": "107"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CO)C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COc1ccc(C2=NN(C3CCNCC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+]>>COc1ccc(C2=NN(C3CCN(C(=O)[C@H](CO)NC(=O)OC(C)(C)C)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(Br)c(OC)c1-c1cccnc1.OB(O)c1ccccc1>>COc1ccc(-c2ccccc2)c(OC)c1-c1cccnc1",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.NCc1cn(-c2ccc(I)cc2)cn1.O.O=C(O)c1ccc2cc[nH]c2c1>>O=C(NCc1cn(-c2ccc(I)cc2)cn1)c1ccc2cc[nH]c2c1",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.COC(=O)/C=C/c1ccc(OC)c(O)c1C.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>COC(=O)/C=C/c1ccc(OC)c(OS(=O)(=O)C(F)(F)F)c1C",
        "output": "731"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Cc1cc([N+](=O)[O-])c(F)cc1Br.CC(=O)O.[Fe]>>CC(=O)Cc1cc(N)c(F)cc1Br",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)c1scnc1-c1ccccc1OC.[Na+].[OH-]>>COc1ccccc1-c1ncsc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](O)C1.Cl.ClCc1ccncc1>>CC(C)(C)OC(=O)N1CC[C@@H](OCc2ccncc2)C1",
        "output": "208"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)CCNC(=O)c1ccc(C(Nc2nc3ccc(F)cc3cc2C)C2CC(C)(C)C2)cc1.CO.Cl.[Na+].[OH-]>>Cc1cc2cc(F)ccc2nc1NC(c1ccc(C(=O)NCCC(=O)O)cc1)C1CC(C)(C)C1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCP(CCCC)CCCC.CO/N=C(\\COc1ccc(CO)cc1)c1ccccc1.COC(=O)CC(=O)c1ccc(O)cc1.Cc1ccccc1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CO/N=C(\\COc1ccc(COc2ccc(C(=O)CC(=O)OC)cc2)cc1)c1ccccc1",
        "output": "347"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)/C=C/c1ccc(C)c(-c2cc3c(cc2C)C(C)(C)CCC3(C)C)c1.CO.Cl.O.[K+].[OH-]>>Cc1ccc(/C=C/C(=O)O)cc1-c1cc2c(cc1C)C(C)(C)CCC2(C)C",
        "output": "122"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.FS(F)(F)(F)(F)c1ccc(C=Cc2nc(CCl)co2)cc1.O.Oc1ccc(CCCCn2ccnn2)cc1.[H-].[Na+]>>FS(F)(F)(F)(F)c1ccc(/C=C/c2nc(COc3ccc(CCCCn4ccnn4)cc3)co2)cc1",
        "output": "760"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COCCBr.O=C(O)C(F)(F)F.O=C([O-])[O-].Oc1cc(OC2CCOCC2)c2c(Nc3ccc(F)c(Cl)c3)ncnc2c1.[K+].[K+]>>COCCOc1cc(OC2CCOCC2)c2c(Nc3ccc(F)c(Cl)c3)ncnc2c1",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)C=O.CS(=O)(=O)c1ccc(C(CC2CCC(=O)CC2)C(=O)O)cc1Cl.ClCCl.Nc1cnccn1.O=C(Cl)C(=O)Cl.O=C(O)CC(O)(CC(=O)O)C(=O)O.c1ccncc1>>CS(=O)(=O)c1ccc(C(CC2CCC(=O)CC2)C(=O)Nc2cnccn2)cc1Cl",
        "output": "692"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCCBr.CN(C)C=O.COC(=O)COc1ccc(O)cc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>COC(=O)COc1ccc(OCCBr)cc1[N+](=O)[O-]",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCC(C#N)(c2ccc(F)cc2)CC1.CCO.[NH4+].[Ni].[OH-]>>CC(C)(C)OC(=O)N1CCC(CN)(c2ccc(F)cc2)CC1",
        "output": "246"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)c1cc(-c2c(OCc3ccccc3)cc(OCc3ccccc3)cc2Oc2ccc([N+](=O)[O-])cc2)on1.CCOC(C)=O.Cl.[K+].[OH-]>>O=C(O)c1cc(-c2c(OCc3ccccc3)cc(OCc3ccccc3)cc2Oc2ccc([N+](=O)[O-])cc2)on1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)OC(=O)c1cc(C#N)c(N2CCC(C(=O)O)CC2)nc1CN1CCCC1=O.CC1CCC(CS(N)(=O)=O)CC1>>CC1CCC(CS(=O)(=O)NC(=O)C2CCN(c3nc(CN4CCCC4=O)c(C(=O)OC(C)C)cc3C#N)CC2)CC1",
        "output": "644"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COCC1(c2cc(C(=O)OC)ccc2-c2cc(OC)ncc2F)CCCC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COCC1(c2cc(CO)ccc2-c2cc(OC)ncc2F)CCCC1",
        "output": "444"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1cccc(-n2c(=O)[nH]c3ccccc3c2=O)c1.Cl.O.[Na+].[OH-]>>O=C(O)c1cccc(-n2c(=O)[nH]c3ccccc3c2=O)c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1c(C)nc2ccc([N+](=O)[O-])cc2c1-c1ccccc1.CCOC(C)=O.[Pd]>>CCOC(=O)c1c(C)nc2ccc(N)cc2c1-c1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCc1oc2ccccc2c1C(=O)NCc1ccc2c(-c3ccc(C(C)(C)C)cc3)c(OCC#N)ccc2c1.CN(C)C=O.O.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+].[Na+].[OH-]>>CCCCc1oc2ccccc2c1C(=O)NCc1ccc2c(-c3ccc(C(C)(C)C)cc3)c(OCc3nnn[nH]3)ccc2c1",
        "output": "366"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)CSCC1(c2ccc3c(c2)OCO3)OCC(C)(C)CO1.O.[Li+].[OH-]>>CC1(C)COC(CSCC(=O)O)(c2ccc3c(c2)OCO3)OC1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CNNC(=O)c1cnc(-c2ccccc2)nc1.N>>NC(=O)CNNC(=O)c1cnc(-c2ccccc2)nc1",
        "output": "163"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1CCNCC1.CC(C)(C)[O-].Cc1ccccc1.Clc1ccnc(Cl)c1.O.[Na+].[Pd+2]>>CC(C)(C)OC(=O)N1CCN(c2cc(Cl)ccn2)CC1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCN(CC)CC.Cc1ccccc1N1CCNCC1.O=C1c2ccccc2C(=O)N1CCCBr>>Cc1ccccc1N1CCN(CCCN2C(=O)c3ccccc3C2=O)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(O)(C=Cc1ccc(C(CC)(CC)c2ccc(OCC(=O)O)c(C)c2)cc1C)CC.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cl.ClCCl.NCCNC(=O)OCC1c2ccccc2-c2ccccc21.O.O.On1nnc2ccccc21>>CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(OCC(=O)NCCNC(=O)OCC3c4ccccc4-c4ccccc43)c(C)c2)cc1C)CC",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(-n2nc(C(C)C)cc2N)cc1.ClCCl.O=C(Cl)Oc1ccccc1.O=C([O-])[O-].[K+].[K+]>>COc1ccc(-n2nc(C(C)C)cc2NC(=O)Oc2ccccc2)cc1",
        "output": "700"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CCOc1ccc2ccccc2c1C=O.CCCBr.O=Cc1c(O)ccc2ccccc12>>CCCOc1ccc2ccccc2c1C=O",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1ccc(OCC2CC2)c(C=O)c1.[Na+].[OH-]>>O=Cc1cc(C(=O)O)ccc1OCC1CC1",
        "output": "222"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccc2[nH]c(C3CCNCC3)nc2c1.CC(C)O.CCN(C(C)C)C(C)C.CCc1cnc(Cl)nc1>>CCc1cnc(N2CCC(c3nc4cc(Br)ccc4[nH]3)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.O=C(CN1CCCC1)Nc1ccc(Br)cc1>>Brc1ccc(NCCN2CCCC2)cc1",
        "output": "112"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.CCOC(=O)c1cc(C2CC2)c2c(C)c(-c3ccc(N)cc3)ccn2c1=O.O.c1ccncc1>>CCOC(=O)c1cc(C2CC2)c2c(C)c(-c3ccc(NC(C)=O)cc3)ccn2c1=O",
        "output": "6"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCC1CCN(c2ccc(CN)cc2)CC1.CCN(CC)CC.CCO.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClCCl.Cn1cc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1C(=O)O.F[B-](F)(F)F>>CCCC1CCN(c2ccc(CNC(=O)c3cc(NC(=O)c4ccccc4-c4ccc(C(F)(F)F)cc4)cn3C)cc2)CC1",
        "output": "905"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(=O)Cl.ClCCl.O=C(O)C(F)(F)F.O=c1c2cnn(-c3cccc(Br)c3)c2ncn1CC1(O)CCNCC1>>CN(C)C(=O)N1CCC(O)(Cn2cnc3c(cnn3-c3cccc(Br)c3)c2=O)CC1",
        "output": "258"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[O-].CCOC(C)=O.Cc1nc(Cl)c2ccccc2c1CC(=O)O.O.Oc1ccc(Cl)cc1.[K+]>>Cc1nc(Oc2ccc(Cl)cc2)c2ccccc2c1CC(=O)O",
        "output": "516"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C#N)CCl.CN(C)C=O.NC(=O)c1c[nH]nc1Nc1ccc(F)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C#N)Cn1cc(C(N)=O)c(Nc2ccc(F)cc2)n1",
        "output": "604"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C=C(C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CC(O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>CC(C)(C=C(C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CC(O)C1",
        "output": "781"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cl.O=Cc1cc(Br)ccc1F.[BH4-].[Na+]>>OCc1cc(Br)ccc1F",
        "output": "356"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)OCc1cc2n(n1)CCN(c1ccc(F)cc1)C2=O.CO.O.[Li+].[OH-]>>O=C1c2cc(CO)nn2CCN1c1ccc(F)cc1",
        "output": "348"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN(c1cccc2cc(C3=NCC(CC(=O)O)S3)[nH]c12)S(=O)(=O)c1cccs1.CN1CCNCC1.Cl.On1nnc2ccccc21>>CN1CCN(C(=O)CC2CN=C(c3cc4cccc(N(C)S(=O)(=O)c5cccs5)c4[nH]3)S2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(F)(F)C(=O)O.CCOC(C)=O.COc1ccc([C@@H](Oc2ccc3c(cnn3-c3cccc(Br)c3)c2)[C@@H](N)COC(C)(C)C)cn1.O.O=C(n1ccnc1)n1ccnc1>>COc1ccc([C@@H](Oc2ccc3c(cnn3-c3cccc(Br)c3)c2)[C@H](COC(C)(C)C)NC(=O)C(C)(F)F)cn1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O=C(O)c1ccc(O)cc1.OCCCCCCBr.[K+].[OH-]>>O=C(O)c1ccc(OCCCCCCO)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)OCCCCCOCc1ccccc1.O=C1c2ccccc2C(=O)N1CCOc1cccc(O)c1>>O=C1c2ccccc2C(=O)N1CCOc1cccc(OCCCCCOCc2ccccc2)c1",
        "output": "702"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)OB(c2cncc(C#N)c2)OC1(C)C.O=C(Nc1ccc(SC(F)(F)F)cc1)c1cnc(N2CC[C@H](CO)C2)c(Br)c1>>N#Cc1cncc(-c2cc(C(=O)Nc3ccc(SC(F)(F)F)cc3)cnc2N2CC[C@H](CO)C2)c1",
        "output": "967"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.ClCCl.O.O=C(O)C1CCN(C(=O)c2cc3ccccc3n2Cc2ccc(Cl)cc2)CC1.On1nnc2ccccc21>>O=C(c1cc2ccccc2n1Cc1ccc(Cl)cc1)N1CCC(C(=O)N2CCCC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)CBr.CCOC(=O)Cc1c(C(C)C)[nH]c2cccc([N+](=O)[O-])c12.CN(C)C=O.[H-].[Na+]>>CCOC(=O)Cc1c(C(C)C)n(CC(=O)OCC)c2cccc([N+](=O)[O-])c12",
        "output": "310"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CCN(CC)CC.CN(C)C=O.NC(=O)Nc1[nH]c(-c2ccccc2O)cc1C(N)=O>>CC(=O)Oc1ccccc1-c1cc(C(N)=O)c(NC(N)=O)[nH]1",
        "output": "111"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCCN.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl.O.O=C(O)COc1ccc(C(=O)c2ccccc2)cc1.On1nnc2ccccc21>>CC(C)(C)OC(=O)NCCNC(=O)COc1ccc(C(=O)c2ccccc2)cc1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Cl[Sn]Cl.O=C([O-])O.O=c1[nH]n(Cc2ccccc2Cl)c2cc(Cl)c([N+](=O)[O-])cc12.[Na+]>>Nc1cc2c(=O)[nH]n(Cc3ccccc3Cl)c2cc1Cl",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.CC(C)OC(C)C.CCOC(=O)CC(=O)c1cc(F)c(N2CCC(N)C2)nc1Nc1ccc(F)cc1F.ClC(Cl)Cl.O>>CCOC(=O)CC(=O)c1cc(F)c(N2CCC(NC(C)=O)C2)nc1Nc1ccc(F)cc1F",
        "output": "339"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(COc2cc3nccc(Oc4ccc(NC(=O)NC5CC5)c(Cl)c4)c3cc2C#N)CC1.CCOC(C)=O.O.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>N#Cc1cc2c(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)ccnc2cc1OCC1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(Cl)c(F)c2)[C@H](CN)C1.Nc1cccnc1C(=O)O>>CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(Cl)c(F)c2)[C@H](CNC(=O)c2ncccc2N)C1",
        "output": "137"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc(C)c(N)c(O)c1.COc1cc(C)c2nc(-c3ccc(O)cc3)oc2c1>>Cc1cc(O)cc2oc(-c3ccc(O)cc3)nc12",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1cnc2c(c1)CC1(C2)C(=O)NC(=O)N1C.Cl.O.[Li+].[OH-]>>CN1C(=O)NC(=O)C12Cc1cc(C(=O)O)cnc1C2",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CCN(CC)CC.Cc1nc(N)nc2c1C(=NOCC(=O)O)CC(c1ccccc1-c1ccccc1)C2.ClCCl.O=S(Cl)Cl>>Cc1nc(N)nc2c1C(=NOCC(=O)N1CCOCC1)CC(c1ccccc1-c1ccccc1)C2",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[P-](F)(F)(F)(F)F.NCc1nnn[nH]1.O=C(O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1>>O=C(NCc1nnn[nH]1)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccc(Br)cc1F.CCOC(C)=O.[Br-]>>O=C(CBr)c1ccc(Br)cc1F",
        "output": "360"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)NC3CC3)cc2)nc2c1CNC2.NC(=O)NCCC(=O)O>>C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)NC3CC3)cc2)nc2c1CN(C(=O)CCNC(N)=O)C2",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[SiH2]OC(C)(C)C1CC(O)CCO1.CCN(CC)CC.CS(C)=O>>CC(C)(C)[SiH2]OC(C)(C)C1CC(=O)CCO1",
        "output": "87"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)[Si](C)(C)OCCc1ccc(CC=O)s1.CN1CCCC1=O.Cc1nc(C(=O)N2CCOC3(CCNCC3)C2)cs1.O=C(O)C(F)(F)F.[Na+]>>Cc1nc(C(=O)N2CCOC3(CCN(CCc4ccc(CCO[Si](C)(C)C(C)(C)C)s4)CC3)C2)cs1",
        "output": "484"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc(N)cc(O)c1.COc1ccc(C(=O)Cl)cc1.Cl.c1ccncc1>>COc1ccc(C(=O)Nc2cc(O)cc(OC)c2)cc1",
        "output": "11"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1cc2cc(Cl)cc(C(=O)OC)c2[nH]1.CO.Cc1cc2cc(Cl)cc(C(=O)O)c2[nH]1.[Na+].[OH-]>>CCc1cc2cc(Cl)cc(C(=O)O)c2[nH]1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)Cc1cc(C2CCN(S(=O)(=O)c3cccc(S(C)(=O)=O)c3)CC2)c2cc(F)ccc2c1.O.O.[Li+].[OH-]>>CS(=O)(=O)c1cccc(S(=O)(=O)N2CCC(c3cc(CC(=O)O)cc4ccc(F)cc34)CC2)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CC2(CCN1)OCCO2.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1ccc2ncccc2c1CC=O.ClCCl.O=C([O-])O.[Na+].[Na+]>>COc1ccc2ncccc2c1CCN1CCC2(CC1)OCCO2",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)c1cc(N)[nH]n1.CC(C)[Si](Oc1ccc(I)cc1Cl)(C(C)C)C(C)C.CN[C@@H]1CCCC[C@H]1NC.Cc1ccccc1.O=C([O-])[O-].[Cu]I.[K+].[K+]>>CC(C)[Si](Oc1ccc(-n2nc(C(C)(C)C)cc2N)cc1Cl)(C(C)C)C(C)C",
        "output": "901"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1cccc(-n2c(=O)c(=O)[nH]c3c4c(ccc32)CCCC4)c1.O=S(=O)(Cl)c1cccc2ccccc12>>O=c1[nH]c2c3c(ccc2n(-c2cccc(NS(=O)(=O)c4cccc5ccccc45)c2)c1=O)CCCC3",
        "output": "68"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCc1nn(C2CCCC2)c2cc(C(=O)Cl)ccc12.Nc1ccccn1>>CCc1nn(C2CCCC2)c2cc(C(=O)Nc3ccccn3)ccc12",
        "output": "463"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN=C=NCCCN(C)C.CN1CCOCC1.COC[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.ClCCl.Nc1ccc(F)cc1Nc1ccccc1.On1nnc2cccnc21>>COC[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc(F)cc1Nc1ccccc1",
        "output": "365"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(=O)CCN.CCOC(C)=O.CN(C)C=O.Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccc(Oc2ccc(C(=O)O)cc2)cc1)Cc1ccc(F)cc1F.Cl.Cl.O.On1nnc2ccccc21>>CCOC(=O)CCNC(=O)c1ccc(Oc2ccc(CN(Cc3ccc(F)cc3F)c3cccc(NS(C)(=O)=O)c3C)cc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCOC(=O)N[C@@H](CC(C)C)C(=O)O.CO.Cl.O=C([O-])O.[Na+]>>C=CCOC(=O)N[C@@H](CC(C)C)C(=O)OC",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cl.ClCCl.NC1CCN2CCc3ccccc3C2C1>>CS(=O)(=O)NC1CCN2CCc3ccccc3C2C1",
        "output": "493"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1csc(-n2cc(CCC(C)(C)C)c3ccc(Cl)cc32)n1.[Na+].[OH-]>>CC(C)(C)CCc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(N)cc1-c1c(Br)cnn1C(C)C.ClCCl.O=C=Nc1ccc(F)c(F)c1>>COc1ccc(NC(=O)Nc2ccc(F)c(F)c2)cc1-c1c(Br)cnn1C(C)C",
        "output": "804"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@H]([NH3+])c1ccc(C(C)(C)C)cc1.Cc1c(C)n(Cc2ccc(-c3ccccc3C(=O)OC(C)(C)C)cc2)c2ccc(C(=O)O)cc12.F[P-](F)(F)(F)(F)F.[Cl-]>>Cc1c(C)n(Cc2ccc(-c3ccccc3C(=O)OC(C)(C)C)cc2)c2ccc(C(=O)N[C@@H](C)c3ccc(C(C)(C)C)cc3)cc12",
        "output": "753"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)C1=C(CBr)CS(=O)[C@@H]2C(NC(=O)Cc3ccccc3)C(=O)N12.O=C(O)C(F)(F)F>>O=C(Cc1ccccc1)NC1C(=O)N2C(C(=O)O)=C(CBr)CS(=O)[C@H]12",
        "output": "158"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C(=O)N1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1)c1ccc([N+](=O)[O-])cc1.Cl.[Na+].[OH-]>>CC(CN1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1)c1ccc([N+](=O)[O-])cc1",
        "output": "112"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCC(Cn1ccnc1)c1ccc(Cl)cc1Cl.O.O=S(=O)(O)O.O=[N+]([O-])O>>CCCCC(Cn1ccnc1)c1cc([N+](=O)[O-])c(Cl)cc1Cl",
        "output": "21"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CNOC.Cl.ClCCl.O=C(O)c1cccnc1Cl.O=S(Cl)Cl.c1ccccc1.c1ccncc1>>CON(C)C(=O)c1cccnc1Cl",
        "output": "879"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cl[Sn]Cl.O.O.O=[N+]([O-])c1cc(Br)c(O)c(Br)c1>>Nc1cc(Br)c(O)c(Br)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C=CCBr.Cc1c(C(O)CCOCc2ccccc2)sc2cc(C(F)(F)F)ccc12.Cl.O.[H-].[Na+]>>C=CCOC(CCOCc1ccccc1)c1sc2cc(C(F)(F)F)ccc2c1C",
        "output": "120"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1c(-c2ccc(F)nc2)nc2cc(F)cc(F)c2c1Cl.Cc1ccccc1.Nc1cc(N2CCOCC2)cnc1N1CCOCC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1c(-c2ccc(F)nc2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)cnc1N1CCOCC1",
        "output": "859"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1sc(N2CCN(Cc3ccc(C(F)(F)F)cc3)C2=O)cc1C.CCOC(=O)c1sc(N2CCN(Cc3ccc4nonc4c3)C2=O)nc1C>>Cc1nc(N2CCN(Cc3ccc4nonc4c3)C2=O)sc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCc1ccc2c(n1)C(N)CCC2.CN=C=S>>CCc1ccc2c(n1)C(NC(=S)NC)CCC2",
        "output": "79"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1cc(Cl)c2c(c1)CC(CO)O2.ClCCl.O>>Cc1cc(Cl)c2c(c1)CC(COS(C)(=O)=O)O2",
        "output": "0"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CCc1nn[nH]n1)C(=O)O.CCCCOC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.ClCCl.F[P-](F)(F)(F)(F)F>>CCCCOC(=O)N1CCN(C(=O)[C@H](CCc2nn[nH]n2)NC(=O)OC(C)(C)C)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)nc1-c1ccnc(NC2CCCCC2)c1.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)c1ccc(N2CCNCC2)nc1-c1ccnc(NC2CCCCC2)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)c1ncc2c(cc(-c3ccc(C(F)(F)F)cc3)c(=O)n2Cc2ccccc2)c1O.ClCCl.O=C1CCC(=O)N1Br>>COC(=O)c1nc(Br)c2c(cc(-c3ccc(C(F)(F)F)cc3)c(=O)n2Cc2ccccc2)c1O",
        "output": "665"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.COC(=O)c1ccc(CN)cc1.Cl.Cl.ClCCl.O.O=C(O)c1cc(F)cnc1Oc1ccc(F)cc1.On1nnc2ccccc21>>COC(=O)c1ccc(CNC(=O)c2cc(F)cnc2Oc2ccc(F)cc2)cc1",
        "output": "790"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCc1cnc(Cl)nc1.CN(C)C=O.CS(=O)(=O)c1cc(F)c(N[C@H]2CCCN(C3CCNCC3)C2=O)cc1F.Cl>>CCc1cnc(N2CCC(N3CCC[C@H](Nc4cc(F)c(S(C)(=O)=O)cc4F)C3=O)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC[C@@H](CO)C1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CN1CCC[C@@H](CO)C1",
        "output": "881"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(O)c1ccc([N+](=O)[O-])cc1.CCOC(C)=O.CO.O=C[O-].[NH4+].[Pd]>>CC(C)(O)c1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCCOC.FC(F)(F)c1ccnc(Cl)c1.O.OB(O)c1ccccc1Cl>>FC(F)(F)c1ccnc(-c2ccccc2Cl)c1",
        "output": "865"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(C(C)C)C(C)C.Cl.O.O.[Li]O.c1ccc(-c2cnc3[nH]ncc3c2N2CCNCC2)cc1>>CC(C)(C)OC(=O)N1CCN(c2c(-c3ccccc3)cnc3[nH]ncc23)CC1",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1cccs1.Nc1ccc2nccnc2c1.O=C(O)C1CCN(c2cccs2)CC1>>O=C(Nc1ccc2nccnc2c1)C1CCN(c2cccs2)CC1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.O=C1CCC(=O)N1Br.c1ccc(N2CCCCCC2)cc1>>Brc1ccc(N2CCCCCC2)cc1",
        "output": "4"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CN[C@@H]1CC[C@H](C(=O)OC)CC1.O.[Na+].[OH-]>>CN[C@@H]1CC[C@H](C(=O)O)CC1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CN)c1.N#Cc1cnc(Cl)nc1>>Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ncc(C#N)cn2)c1",
        "output": "544"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NC1CCNCC1.CCN(CC)CC.Cc1ccc2c(Cl)nc(-c3c(O)cccc3F)nc2c1.ClCCl>>Cc1ccc2c(N3CCC(NC(=O)OC(C)(C)C)CC3)nc(-c3c(O)cccc3F)nc2c1",
        "output": "162"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Cl.ClCCl.Cn1c(CC[C@@](C)(N)CO)ccc1C(=O)CCCCc1ccccc1>>Cn1c(CC[C@](C)(CO)NC(=O)OC(C)(C)C)ccc1C(=O)CCCCc1ccccc1",
        "output": "631"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.O=CC1CN(Cc2ccccc2)CC1c1ccccc1.[Na+].c1ccc(CC2CCNCC2)cc1>>c1ccc(CC2CCN(CC3CN(Cc4ccccc4)CC3c3ccccc3)CC2)cc1",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.OCC1CC(OCc2ccccc2)C1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCC1CC(OCc2ccccc2)C1",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)SC1COC(c2ccc(F)cc2F)C1.CC(C)O.CCCCCC.CCOC(C)=O.CO.C[O-].Cl.[Na+]>>Fc1ccc(C2CC(S)CO2)c(F)c1",
        "output": "90"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(I)cc(S(C)(=O)=O)c2)c1CCC(=O)OCC.Cl[Pd]Cl.O=C([O-])[O-].OB(O)c1ccc(F)c(F)c1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)c(F)c3)cc(S(C)(=O)=O)c2)c1CCC(=O)OCC",
        "output": "855"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCC.COC(=O)c1ccc(NC(=O)N(c2c3cc(F)c(F)cc3nn2-c2ccc(Cl)cc2)C2CCCCC2)c(Cl)c1.ClCCl.[Li+].[OH-]>>O=C(O)c1ccc(NC(=O)N(c2c3cc(F)c(F)cc3nn2-c2ccc(Cl)cc2)C2CCCCC2)c(Cl)c1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1ccc(-c2nc3cc(N)ccc3o2)cc1.ClCCCl.ClCCl.O=Cc1ccncc1.[Na+]>>Cc1ccc(-c2nc3cc(NCc4ccncc4)ccc3o2)cc1",
        "output": "359"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.NS(=O)(=O)c1cc(C(=O)O)ccc1NC1CC1.O=S(=O)(O)O>>COC(=O)c1ccc(NC2CC2)c(S(N)(=O)=O)c1",
        "output": "33"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=O.CO.COc1cccc2c1C[C@H]1NCCO[C@@H]1C2.[H][H].[Pd]>>COc1cccc2c1C[C@@H]1[C@@H](C2)OCCN1C",
        "output": "217"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=Cc1ccc(C(=O)O)cc1.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.CN(C)C=O.Cc1cc(C(O)(C(C)c2ccc(Br)cc2Cl)C(F)(F)F)ccn1.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.O.[Pd+2]>>Cc1cc(C(O)(C(C)c2ccc(/C=C/c3ccc(C(=O)O)cc3)cc2Cl)C(F)(F)F)ccn1",
        "output": "539"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Oc1ccc(OCc2ccccc2)c(N)c1.CS(=O)(=O)Cl.O.c1ccncc1>>CC(=O)Oc1ccc(OCc2ccccc2)c(NS(C)(=O)=O)c1",
        "output": "194"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)O.CCc1nc2ccc(C#N)cc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1.[K+].[OH-]>>CCc1nc2ccc(C(N)=O)cc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1",
        "output": "419"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)c1ccc(N)c(SC(F)(F)F)c1.ClCCl.O=C1CCC(=O)N1Br>>CC(C)(C)c1cc(Br)c(N)c(SC(F)(F)F)c1",
        "output": "4"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1c(NC(=O)OC(C)(C)C)oc2cc(C3CCC3)cnc12.CCOC(C)=O.CO.Cl.O.O.[Li]O>>CC(C)(C)OC(=O)Nc1oc2cc(C3CCC3)cnc2c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(O)(CC)CCCO.COC(=O)C1CC2CC1C1C3C=CC(C3)C21>>CCC(O)(CC)CCCOC(=O)C1CC2CC1C1C3C=CC(C3)C21",
        "output": "289"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)C[AlH]CC(C)C.COC(=O)CCCCC=C1CCC1.Cc1ccccc1>>OCCCCCC=C1CCC1",
        "output": "343"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)CCI.CCn1ncc2c([N+](=O)[O-])cccc21.O=[N+]([O-])c1cccc2[nH]ncc12>>CC(C)CCn1ncc2c([N+](=O)[O-])cccc21",
        "output": "346"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1nc(C(=O)O)c(-c2ccc(F)cc2)s1.O=C(NC1CCCNC1)c1cccc2occc12>>Cc1nc(C(=O)N2CCCC(NC(=O)c3cccc4occc34)C2)c(-c2ccc(F)cc2)s1",
        "output": "747"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(C)COC(=O)Oc1ccc(O)cc1.CCCCCCCCc1ccc(-c2ccc(C(=O)Cl)cc2)cc1.Cc1ccccc1.c1ccncc1>>CCCCCCCCc1ccc(-c2ccc(C(=O)Oc3ccc(OC(=O)OCC(C)CC)cc3)cc2)cc1",
        "output": "482"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCCBr.CC(C)=O.O=C([O-])[O-].[Cs+].[Cs+].c1ccc(-c2nc3ccccc3[nH]2)cc1>>BrCCCCn1c(-c2ccccc2)nc2ccccc21",
        "output": "495"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COc1ccc2c(c1F)CCC2(Cc1ccc(C(F)(F)F)nc1)C(C)=O.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.C[Si](C)(C)Cl.[Br-].[Br-].[Br-]>>COc1ccc2c(c1F)CCC2(Cc1ccc(C(F)(F)F)nc1)C(=O)CBr",
        "output": "360"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrC(Br)(Br)Br.CCOC(=O)c1cccc(-c2cccc(CO)c2)c1.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1cccc(-c2cccc(CBr)c2)c1",
        "output": "750"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CO.COC(=O)[C@@H]1CCCC[C@@H]1N.O=C([O-])O.O=Cc1ccc(F)cc1.[BH3-]C#N.[Na+].[Na+]>>COC(=O)[C@@H]1CCCC[C@@H]1NCc1ccc(F)cc1",
        "output": "468"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCNCc1ncc[nH]1.Cc1ccc(N(CC(=O)O)S(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1>>CCN(Cc1ncc[nH]1)C(=O)CN(c1ccc(C)cc1)S(=O)(=O)c1ccc(C(C)(C)C)cc1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "NC(=O)c1cc(-c2cccnc2[C@@H](N)Cc2cc(F)cc(F)c2)ccc1F.O=C(O)C(F)(F)F.O=C(O)Cc1cc(=O)[nH]c2ccccc12>>NC(=O)c1cc(-c2cccnc2[C@H](Cc2cc(F)cc(F)c2)NC(=O)Cc2cc(=O)[nH]c3ccccc23)ccc1F",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)OCCN(Cc1nc3ccccc3[nH]1)C2.NO.[Na+].[OH-]>>O=C(NO)c1ccc2c(c1)OCCN(Cc1nc3ccccc3[nH]1)C2",
        "output": "988"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.COC(=O)[C@H]1CN(CCn2c(=O)ccc3c(F)cc(F)cc32)CC[C@H]1N.ClCCl.O=Cc1cc2c(cn1)OCCO2.[Na+]>>COC(=O)[C@H]1CN(CCn2c(=O)ccc3c(F)cc(F)cc32)CC[C@H]1NCc1cc2c(cn1)OCCO2",
        "output": "775"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cn1c(C(C)(C)C)c/c(=N\\C(=O)c2cc([N+](=O)[O-])cc(C(F)(F)F)c2)n1C[C@H]1CCCO1.[OH-].[OH-].[Pd+2]>>Cn1c(C(C)(C)C)c/c(=N\\C(=O)c2cc(N)cc(C(F)(F)F)c2)n1C[C@H]1CCCO1",
        "output": "489"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCCCC1.C1CCOC1.CCOCC.CN(C)C=O.Cc1cc(O[Si](C)(C)C(C)(C)C)cc(C)c1Br.[Br-].[Li+].[Li]C.[Li]C(C)CC>>Cc1cc(O[Si](C)(C)C(C)(C)C)cc(C)c1C=O",
        "output": "638"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)[C@@H](N)[C@@H](C)O.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(N2CCN(c3ccc(CN4CCOCC4)cc3)CC2)cc1>>COC(=O)[C@@H](NC(=O)c1ccc(N2CCN(c3ccc(CN4CCOCC4)cc3)CC2)cc1)[C@@H](C)O",
        "output": "652"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)c1c(SC)nc2c(Br)cc(C)cn12.Cl.[Na+].[OH-]>>CSc1nc2c(Br)cc(C)cn2c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.COc1ccc2cc(C(C)=O)cc(N3CCNCC3)c2c1.Cl.O.[Na+].[OH-]>>COc1ccc2cc(C(C)=O)cc(N3CCN(C(=O)OC(C)(C)C)CC3)c2c1",
        "output": "694"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)CC(C)(C)CN.CS(=O)(=O)c1nccc(-c2cccnc2Oc2ccc(Nc3nnc(-c4ccccc4)c4ccccc34)cc2)n1.CS(C)=O>>CN(C)CC(C)(C)CNc1nccc(-c2cccnc2Oc2ccc(Nc3nnc(-c4ccccc4)c4ccccc34)cc2)n1",
        "output": "629"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.O=C(c1ccc(Oc2ccc([N+](=O)[O-])cn2)cc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1.[C].[Pt]>>Nc1ccc(Oc2ccc(C(=O)N3CCN(Cc4ccc5c(c4)OCO5)CC3)cc2)nc1",
        "output": "269"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCc1noc(C)c1-c1[nH]c2ccccc2c1C(=O)CCN(C)C.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCc1noc(C)c1-c1[nH]c2ccccc2c1C(O)CCN(C)C",
        "output": "449"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.O=C(O)[C@@H]1CC(Sc2ccc(F)cc2)(c2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2)CN1.O=S(=O)(O)O.[Na+].[OH-]>>OC[C@@H]1CC(Sc2ccc(F)cc2)(c2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2)CN1",
        "output": "218"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.COc1ccc(Cl)cc1I.ClCCl.O>>Oc1ccc(Cl)cc1I",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCc1nc2c(F)ccc(OCC(=O)OC)c2c(OC(F)F)c1Cc1ccc(C(C)=O)cc1.CO.[Li+].[OH-]>>CCc1nc2c(F)ccc(OCC(=O)O)c2c(OC(F)F)c1Cc1ccc(C(C)=O)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.CN.CN(C)c1ccncc1.Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)O)cc1C(=O)Nc1nccs1.Cl.Cl.ClCCl>>CNC(=O)c1ccc(-c2cc(C(=O)NC3CC3)cc(F)c2C)c(C(=O)Nc2nccs2)c1",
        "output": "836"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCN(CC2CCCCN2)CC1.ClCCCl.ClCCl.[Na+]>>CN1CCCCC1CN1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "217"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Clc1ncccn1.O=C(c1ccc(-c2cnco2)cc1)N(C1CCNCC1)C1CC1>>O=C(c1ccc(-c2cnco2)cc1)N(C1CC1)C1CCN(c2ncccn2)CC1",
        "output": "36"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ncc(-c2ccnc(NC3CCNCC3)n2)n1C(C)C>>Cc1ncc(-c2ccnc(NC3CCN(C(=O)OC(C)(C)C)CC3)n2)n1C(C)C",
        "output": "694"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)C(F)(F)c1ccc(F)cc1OCC.CO.O.O.[Li+].[OH-]>>CCOc1cc(F)ccc1C(F)(F)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCC1(CC(=O)OCC)OCCc2c1[nH]c1c(C)ccc(C#N)c21.CO.[Na+].[OH-]>>CCCC1(CC(=O)O)OCCc2c1[nH]c1c(C)ccc(C#N)c21",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCI.CCOC(C)=O.CN(C)C=O.Nc1cc(O)c(C(=O)CCC2CCN(CC3CCCCC3)CC2)cc1Cl.O=C([O-])[O-].[K+].[K+]>>CCOc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCCCC2)CC1",
        "output": "198"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COCCOC.O.O=C(CN1CCOCC1)Nc1cc(NC(=O)c2ccc(Cl)nc2)ccc1OC(F)(F)F.O=C([O-])[O-].OB(O)c1cccc(F)c1.[K+].[K+]>>O=C(CN1CCOCC1)Nc1cc(NC(=O)c2ccc(-c3cccc(F)c3)nc2)ccc1OC(F)(F)F",
        "output": "865"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.COc1ccc(C(=O)Nc2ccc3cc(OS(=O)(=O)C(F)(F)F)ccc3c2)cc1.ClCCl.O.O=C([O-])[O-].OB(O)c1cccc2cnccc12.[K+].[K+]>>COc1ccc(C(=O)Nc2ccc3cc(-c4cccc5cnccc45)ccc3c2)cc1",
        "output": "825"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CN1CCC(O)CC1.N#Cc1cccc(O)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN1CCC(Oc2cccc(C#N)c2)CC1",
        "output": "846"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.FCCBr.O=C([O-])[O-].O=C1N=C(N2CCCNCC2)SC1=Cc1ccc2c(cnn2Cc2ccc(Cl)cc2C(F)(F)F)c1.[K+].[K+]>>O=C1N=C(N2CCCN(CCF)CC2)SC1=Cc1ccc2c(cnn2Cc2ccc(Cl)cc2C(F)(F)F)c1",
        "output": "73"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.COc1cccc(-c2ccc(C#N)c(F)c2)c1OC.CS(C)=O.NC1CCC(O)CC1>>COc1cccc(-c2ccc(C#N)c(NC3CCC(O)CC3)c2)c1OC",
        "output": "572"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1nc(Cl)cc(Oc2cc(C)c3[nH]c(=O)oc3c2)n1.Cl.ClCCl.O.O=C1Nc2ncccc2C2(CCNCC2)O1>>Cc1nc(Oc2cc(C)c3[nH]c(=O)oc3c2)cc(N2CCC3(CC2)OC(=O)Nc2ncccc23)n1",
        "output": "162"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCOc1nc(N)c2nc(OC)n(Cc3ccc(OCCCBr)cc3)c2n1.CN.CO>>CCCCOc1nc(N)c2nc(OC)n(Cc3ccc(OCCCNC)cc3)c2n1",
        "output": "147"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(F)(F)C(CO)C1.CCCCc1nnc(Cl)cc1-c1ccc(OC2CCCCC2)cc1.[H-].[Na+]>>CCCCc1nnc(OCC2CN(C(=O)OC(C)(C)C)CCC2(F)F)cc1-c1ccc(OC2CCCCC2)cc1",
        "output": "407"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CSc1ccc(C2CCNCC2)cc1.Cl.O>>CSc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2)cc1",
        "output": "694"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1ccc2c(Cl)coc2c1.CO.O.[Na+].[OH-]>>O=C(O)c1ccc2c(Cl)coc2c1",
        "output": "5"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC(C(=O)OC)c1c(C)nc2nc(C(C)C)nn2c1-c1ccc(C)cc1.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc2nc(C(C)C)nn2c1-c1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(S(=O)(=O)n2ccc3c2ncc2nnc([C@@H]4CC[C@H](N)C4)n23)cc1.Cl.ClCCl.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=S(=O)(Cl)CCCCl>>Cc1ccc(S(=O)(=O)n2ccc3c2ncc2nnc([C@@H]4CC[C@H](NS(=O)(=O)CCCCl)C4)n23)cc1",
        "output": "493"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClCCl.O.O=c1ccc(-c2nc(-c3ccc(SC(F)(F)F)cc3)no2)cn1Cc1ccnc(N2CCNCC2)c1>>CC(=O)N1CCN(c2cc(Cn3cc(-c4nc(-c5ccc(SC(F)(F)F)cc5)no4)ccc3=O)ccn2)CC1",
        "output": "125"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CCN(CC)CC.COc1cc2cc(-c3cccc(N)c3)nc(C)c2cc1OC.ClCCl>>COc1cc2cc(-c3cccc(NC(C)=O)c3)nc(C)c2cc1OC",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Cl.ClCCl.Fc1cc2nc(COc3ccccc3)n(Cc3ccc(Cl)cc3)c2cc1N1CCNCC1>>CC(=O)N1CCN(c2cc3c(cc2F)nc(COc2ccccc2)n3Cc2ccc(Cl)cc2)CC1",
        "output": "125"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCN(CC1CC1)c1cc(C(=O)Nc2ccc(C=O)cc2C)ncn1.COCCN.ClCCl>>CCCN(CC1CC1)c1cc(C(=O)Nc2ccc(CNCCOC)cc2C)ncn1",
        "output": "468"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cnc2c(Sc3ccc(Nc4nnc(Cl)c5ccccc45)cc3)ccnc2c1.OCCC1CCCCN1.[H-].[Na+].c1ccccc1>>COc1cnc2c(Sc3ccc(Nc4nnc(OCCC5CCCCN5)c5ccccc45)cc3)ccnc2c1",
        "output": "407"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C1(Cc2ccccc2)CCCN1C(=O)OCc1ccccc1.CO.[K+].[OH-]>>O=C(OCc1ccccc1)N1CCCC1(Cc1ccccc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCC(C)C.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Cc1ccc(-c2nc3c(nc2-c2ccc(C)cc2)N(CCCCCCC(=O)O)CCC3)cc1.ClCCl.NS(=O)(=O)Cc1ccccc1.O.O=C(Cl)C(=O)Cl>>Cc1ccc(-c2nc3c(nc2-c2ccc(C)cc2)N(CCCCCCC(=O)NS(=O)(=O)Cc2ccccc2)CCC3)cc1",
        "output": "644"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CC#N.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C([O-])[O-].OCCc1ccc(Br)cc1.[K+].[K+]>>Brc1ccc(CCN2CCCCC2)cc1",
        "output": "371"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(C)NC.Cl.ClCCl.O=C(Cl)c1cc(-c2ccccc2)nc2ccccc12>>CCC(C)N(C)C(=O)c1cc(-c2ccccc2)nc2ccccc12",
        "output": "201"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccccc1.CN(C)C=O.COc1cc(C(C)=O)ccc1O.O=C([O-])[O-].[K+].[K+]>>COc1cc(C(C)=O)ccc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCOC(=O)CNc1nc(C)c([N+](=O)[O-])c(C)n1.[Na+].[OH-]>>Cc1nc(NCC(=O)O)nc(C)c1[N+](=O)[O-]",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)c1ccc(CC(NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.On1nnc2ccccc21.c1ccc(-c2c[nH]c(C3CCCCN3)n2)cc1>>CC(C)(C)OC(=O)c1ccc(CC(NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)N2CCCCC2c2nc(-c3ccccc3)c[nH]2)cc1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN.CS(C)=O.ClCCl.O=C(O)C(F)(F)F.O=C[C@H]1CC[C@@H](Nc2cc(-c3cccc(NCc4cccc(F)c4)n3)c(Cl)cn2)C1.[Na+]>>CNC[C@H]1CC[C@@H](Nc2cc(-c3cccc(NCc4cccc(F)c4)n3)c(Cl)cn2)C1",
        "output": "426"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Cn1c(COc2ccc(Cl)cc2)cc2ccccc21.O.O=C1CCC(=O)N1Br.O=S(=O)([O-])[O-].[Na+].[Na+]>>Cn1c(COc2ccc(Cl)cc2)c(Br)c2ccccc21",
        "output": "796"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)c1ccncc1.ClCCl.O=C(O)Cc1ccc(C(F)(F)F)cc1.O=C(OCC(Cl)(Cl)Cl)c1ccccc1CSc1ccc(CO)cc1>>O=C(Cc1ccc(C(F)(F)F)cc1)OCc1ccc(SCc2ccccc2C(=O)OCC(Cl)(Cl)Cl)cc1",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(Br)cc1OCC2.CCc1ccccc1B(O)O>>CCc1ccccc1-c1ccc2c(c1)OCCn1cc(-c3ncnn3C(C)C)nc1-2",
        "output": "837"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)Cc1ccc(N(C)c2nc(=O)c3cccnc3s2)cc1.Cl.O.[Na+].[OH-]>>CN(c1ccc(CC(=O)O)cc1)c1nc(=O)c2cccnc2s1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1ccc2c(c1)cc1n2CC(CC2CCN(Cc3ccccc3)CC2)C1=O.ClCCl.O.O=C([O-])[O-].[K+].[K+]>>O=C1c2cc3cc(O)ccc3n2CC1CC1CCN(Cc2ccccc2)CC1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.CC(C)[C@H](CO)Cc1ccc(C(C)(C)C)c(O)c1.CN(C)C=O.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)[C@H](CO)Cc1ccc(C(C)(C)C)c(OCc2ccccc2)c1",
        "output": "127"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)O.CN(C)C1(c2ccccc2)CCC(=O)CC1.Cc1csc([C@@H](N)Cc2c[nH]c3ccccc23)n1.O=S(=O)([O-])[O-].[Na+].[Na+]>>Cc1csc([C@H](Cc2c[nH]c3ccccc23)NC2CCC(c3ccccc3)(N(C)C)CC2)n1",
        "output": "236"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)c1cccc(-c2ccc(C(F)(F)F)cc2)c1.CCO.O.[BH4-].[Na+]>>CC(O)c1cccc(-c2ccc(C(F)(F)F)cc2)c1",
        "output": "24"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=[N+]=[N-].CCCCCc1cc(O)c(C(=O)O)c(O)c1.CCOCC>>CCCCCc1cc(O)c(C(=O)OC)c(O)c1",
        "output": "60"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1cc(C)n(CCO)n1.CI.COCCOC.O=[Ag].[H-].[Na+]>>COCCn1nc(C(C)=O)cc1C",
        "output": "140"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CCBr.CCOc1ccccc1C(=O)CCc1coc(-c2ccc(O)c(OC(F)F)c2)n1>>C=CCOc1ccc(-c2nc(CCC(=O)c3ccccc3OCC)co2)cc1OC(F)F",
        "output": "77"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)c1csc(-c2noc(C(C)(C)O)n2)n1.ClCCl.O=C(O)C(F)(F)F>>CC(C)(O)c1nc(-c2nc(C(=O)O)cs2)no1",
        "output": "569"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CNCCN(C)S(=O)(=O)c1ccc(OC)c(OC)c1.ClCCl.O=S(=O)(Cl)c1ccc2c(c1)OCCCO2>>COc1ccc(S(=O)(=O)N(C)CCN(C)S(=O)(=O)c2ccc3c(c2)OCCCO3)cc1OC",
        "output": "99"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)s1.O=Cc1ccc(O)c(Cl)c1Cl>>O=C(C=Cc1ccc(O)c(Cl)c1Cl)c1ccc(-c2ccc(C(F)(F)F)cc2)s1",
        "output": "295"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCc1ccccc1OCCCOc1ccc2c(=O)cc(C(=O)OCC)oc2c1.CCO.O=C([O-])O.[Na+]>>CCCc1ccccc1OCCCOc1ccc2c(=O)cc(C(=O)O)oc2c1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(Cl)Cl.ClCCl.Cl[Ti](Cl)(Cl)Cl.Fc1ccc2ccccc2c1>>O=Cc1cccc2ccc(F)cc12",
        "output": "591"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#C[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21.C1CCOC1.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.FC(F)(F)c1ccccc1I.I[Cu]I>>CC1(C)O[C@@H]2[C@H](O1)[C@@H](C#Cc1ccccc1C(F)(F)F)O[C@H]2n1cnc2c(NC3CCCC3)ncnc21",
        "output": "664"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)C(CC=C(Br)Br)C(=O)O.CN(C)C=O.O=S(Cl)Cl.c1ccccc1>>CC(C)C(CC=C(Br)Br)C(=O)Cl",
        "output": "53"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(N)cc1OC.Cn1cc(-c2ccnc(Cl)n2)c(-c2ccc(Cl)cc2Cl)n1>>COc1ccc(Nc2nccc(-c3cn(C)nc3-c3ccc(Cl)cc3Cl)n2)cc1OC",
        "output": "907"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COc1ccc2[nH]c(C)c(CC(=O)Nc3ccc(F)cc3)c2c1.ClCCl.O=C(Cl)c1ccc(Cl)cc1[N+](=O)[O-].[H-].[Na+]>>COc1ccc2c(c1)c(CC(=O)Nc1ccc(F)cc1)c(C)n2C(=O)c1ccc(Cl)cc1[N+](=O)[O-]",
        "output": "232"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCC(=O)Cl.CCN(CC)CC.ClC(Cl)Cl.Nc1ccc(N)nc1>>CCCCCC(=O)Nc1ccc(N)nc1",
        "output": "422"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CCc1ccc(C(F)(F)F)cc1.II.O=S(=O)(O)O.O=S([O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[O-][I+3]([O-])([O-])[O-]>>CCc1ccc(C(F)(F)F)cc1I",
        "output": "372"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.COc1ccc(Cl)cc1C(=O)NC1COc2cc(C)ccc2C1O.O=C(O)C(F)(F)F.[Pd]>>COc1ccc(Cl)cc1C(=O)NC1COc2cc(C)ccc2C1",
        "output": "447"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN.CN1CCCC1=O.Cl.Cn1cc(-c2ccc(-c3cncc4ccc(Cl)nc34)cc2)cn1>>CNc1ccc2cncc(-c3ccc(-c4cnn(C)c4)cc3)c2n1",
        "output": "70"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1c(N)cccc1Cl.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>Cc1ccc(S(=O)(=O)Nc2cccc(Cl)c2C)cc1",
        "output": "68"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.CO.COc1cc2c(Oc3ccc([N+](=O)[O-])cc3F)ccnc2cc1OCC1CC2CN(C)CC2C1.[Pd]>>COc1cc2c(Oc3ccc(N)cc3F)ccnc2cc1OCC1CC2CN(C)CC2C1",
        "output": "335"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)NS(C)(=O)=Nc1ccc(Br)cc1.CC1(C)OB(c2ccc(-c3nc4c(cc3Cl)nc(O[C@@H]3CO[C@@H]5[C@H](O)CO[C@@H]53)n4COCC[Si](C)(C)C)cc2)OC1(C)C>>CC(C)NS(C)(=O)=Nc1ccc(-c2ccc(-c3nc4c(cc3Cl)nc(O[C@@H]3CO[C@@H]5[C@H](O)CO[C@@H]53)n4COCC[Si](C)(C)C)cc2)cc1",
        "output": "933"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C1COCCO1.CCOC(=O)COc1cccc(COc2ccc(CCN(C[C@H](O)c3cccc(Cl)c3)C(=O)OC(C)(C)C)cc2)c1.Cl>>CCOC(=O)COc1cccc(COc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(O)CN.O=S(=O)(CCCCl)CCC(F)(F)F>>CC(C)(O)CNCCCS(=O)(=O)CCC(F)(F)F",
        "output": "279"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC[SiH](CC)CC.ClCCl.O=C([O-])O.O=C(c1ccc(F)cc1)c1ccc([N+](=O)[O-])cc1.O=S(=O)(O)C(F)(F)F.[Na+]>>O=[N+]([O-])c1ccc(Cc2ccc(F)cc2)cc1",
        "output": "181"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)OCCCN.CO.NC(=O)c1cnc(Oc2ccc(C=O)cc2F)cn1.[BH4-].[Na+]>>CC(C)OCCCNCc1ccc(Oc2cnc(C(N)=O)cn2)c(F)c1",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NC1CCNCC1.CC(C)O.c1ccc2c(CC3CO3)coc2c1>>CC(C)(C)OC(=O)NC1CCN(CC(O)Cc2coc3ccccc23)CC1",
        "output": "76"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1cnc(Br)s1.C1CCOC1.CC(C)(C)OC(=O)N1CCNCC1.CCN(CC)CC>>CC(C)(C)OC(=O)N1CCN(c2ncc(Br)s2)CC1",
        "output": "657"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.Cc1c(Cl)cc(C(C)C)c2c1CC(CN)O2.O=C(Cl)OCc1ccccc1.O=C(NCC1Cc2cccc(C3CCCC3)c2O1)OCc1ccccc1>>Cc1c(Cl)cc(C(C)C)c2c1CC(CNC(=O)OCc1ccccc1)O2",
        "output": "479"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCn1c(=O)c(NC(=O)Nc2c(C(C)C)cccc2C(C)C)c(-c2cccc(O)c2)c2cccnc21.CN(C)C=O.CN(C)CCCCl.Cl.O.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CCCCn1c(=O)c(NC(=O)Nc2c(C(C)C)cccc2C(C)C)c(-c2cccc(OCCCN(C)C)c2)c2cccnc21",
        "output": "74"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.COC(=O)c1cnc(Cl)cn1.ClCCl.Oc1ccc2c(c1)CCN(C1CCC1)CC2.[H-].[Na+]>>COC(=O)c1cnc(Oc2ccc3c(c2)CCN(C2CCC2)CC3)cn1",
        "output": "210"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1nccc2c(-c3cc(S(C)(=O)=O)ccc3F)cn(C)c12.CS(C)=O.O=C([O-])[O-].Oc1ccc(F)cc1F.[Cs+].[Cs+]>>COc1nccc2c(-c3cc(S(C)(=O)=O)ccc3Oc3ccc(F)cc3F)cn(C)c12",
        "output": "564"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.ClCCl.F[P-](F)(F)(F)(F)F.Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12.O=C(O)c1cccc(F)n1>>O=C(Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12)c1cccc(F)n1",
        "output": "548"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc(C(=O)OC)c(-c2cccnc2)c1.[Na+].[OH-]>>COC(=O)c1ccc(C(=O)O)cc1-c1cccnc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COc1ccc(Br)cc1O[Si](C)(C)C(C)(C)C.NS(=O)(=O)c1cc(C=O)ccc1Cl.[Li]C(C)(C)C>>COc1ccc(C(O)c2ccc(Cl)c(S(N)(=O)=O)c2)cc1O[Si](C)(C)C(C)(C)C",
        "output": "379"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C(=O)OC(C)(C)C)[C@@H]1CNC[C@H]1c1ccc(Cl)cc1.N#Cc1ccc(N2CCC(C(=O)O)CC2)nc1>>CN(C(=O)OC(C)(C)C)[C@@H]1CN(C(=O)C2CCN(c3ccc(C#N)cn3)CC2)C[C@H]1c1ccc(Cl)cc1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.O=C1Nc2cc(Cl)ccc2C1(Cc1cccc(Cl)c1)C1CCCNC1>>CC(=O)N1CCCC(C2(Cc3cccc(Cl)c3)C(=O)Nc3cc(Cl)ccc32)C1",
        "output": "125"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=S(=O)(c1ccc(Cl)c(Cl)c1)C1CCNCC1.O=[N+]([O-])c1cccnc1Cl>>O=[N+]([O-])c1cccnc1N1CCC(S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1",
        "output": "220"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CNCc1cn(S(=O)(=O)c2cccc(F)c2)c2nc(Br)ccc12.ClCCl.O>>CN(Cc1cn(S(=O)(=O)c2cccc(F)c2)c2nc(Br)ccc12)C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC[C@H]1CO[C@@H](C(=O)N(C2CC2)[C@H](C)c2nn(CCCNC(=O)OC)c3nc(C)ccc23)CN1Cc1ccccc1.CO.[OH-].[OH-].[Pd+2]>>CCOC[C@H]1CO[C@@H](C(=O)N(C2CC2)[C@H](C)c2nn(CCCNC(=O)OC)c3nc(C)ccc23)CN1",
        "output": "84"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CI.Cc1cc([N+](=O)[O-])ccc1O.O=C([O-])[O-].[K+].[K+]>>COc1ccc([N+](=O)[O-])cc1C",
        "output": "62"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1cc2cc(O)ccc2[nH]1.O=C(Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1)N1CCC(O)CC1>>CCOC(=O)c1cc2cc(OC3CCN(C(=O)Oc4ccc(Oc5ccc(C(F)(F)F)cn5)cc4)CC3)ccc2[nH]1",
        "output": "846"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)C(CC(C)C)c1cc(O)cc(-c2ccc(C(F)(F)F)cc2)c1.OB(O)c1cccc(C(F)(F)F)c1>>COC(=O)C(CC(C)C)c1cc(Oc2cccc(C(F)(F)F)c2)cc(-c2ccc(C(F)(F)F)cc2)c1",
        "output": "920"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.CO.COc1cc(N(C)CCN(C)C)c(N)cc1Nc1nccc(-c2cn(C)c3ccccc23)n1.O=C(Cl)CCCl.O=C([O-])[O-].[K+].[K+].[Na+].[OH-]>>COc1cc(N(C)CCN(C)C)c(NC(=O)CCCl)cc1Nc1nccc(-c2cn(C)c3ccccc23)n1",
        "output": "134"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.COC(=O)c1cccc2c1ccn2-c1ccc(F)cc1.NN.O.O>>NNC(=O)c1cccc2c1ccn2-c1ccc(F)cc1",
        "output": "421"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.CC(=O)Nc1cc(C)ccc1C.S=C=S.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)Nc1cc(C)c(C(C)=O)cc1C",
        "output": "31"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=C(O)c1c(O)c(-c2ccccc2)nc2ccccc12.O=S(=O)(O)O>>COC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[C@@H]1CN(c2cccc3ccccc23)CCN1.O=C1C2CCCN2C(=O)CN1CCCCBr>>C[C@@H]1CN(c2cccc3ccccc23)CCN1CCCCN1CC(=O)N2CCCC2C1=O",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Brc1ccc2cc[nH]c2c1.CC(=O)c1ccc(B(O)O)cc1>>CC(=O)c1ccc(-c2ccc3cc[nH]c3c2)cc1",
        "output": "909"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCC(CC)(c1ccc(/C=C/C2(O)CCSCC2)c(C)c1)c1ccc(-c2ccc(CC(=O)OC)cc2)c(C)c1.CO.[Na+].[OH-]>>CCC(CC)(c1ccc(/C=C/C2(O)CCSCC2)c(C)c1)c1ccc(-c2ccc(CC(=O)O)cc2)c(C)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)[C@@H]1C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@@H]1N.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CN1CCOCC1.CSCC[C@H](NC(=O)OCc1ccccc1)C(=O)O.F[P-](F)(F)(F)(F)F>>CSCC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H]1CC[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H]1C(C)C",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1cccc(Br)n1.Cc1ccccc1.O.OCCOCc1ccccc1.[H-].[Na+]>>Brc1cccc(OCCOCc2ccccc2)n1",
        "output": "551"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCNc1nc2ccc(OC)cc2cc1C=O>>CCCNc1nc2ccc(OC)cc2cc1CO",
        "output": "476"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COc1cc(CCOP(=O)(OCc2ccccc2)OCc2ccccc2)ccc1OC(C)=O.O=C([O-])[O-].[K+].[K+]>>COc1cc(CCOP(=O)(OCc2ccccc2)OCc2ccccc2)ccc1O",
        "output": "22"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].CCO.COc1cc(N2CCC(C(=O)Cn3nc(C(F)(F)F)cc3C)CC2)ccc1Cl.ClCCCl.ClCCl.N.[BH4-].[NH4+].[Na+].[OH-].[Ti+4]>>COc1cc(N2CCC(C(N)Cn3nc(C(F)(F)F)cc3C)CC2)ccc1Cl",
        "output": "63"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.CC(=O)O.Cl.O.O=[N+]([O-])c1cc(Br)ccc1N[C@H]1CCNC[C@@H]1O.[BH3-]C#N.[Na+]>>CN1CC[C@H](Nc2ccc(Br)cc2[N+](=O)[O-])[C@@H](O)C1",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OC1CNCC(C(=O)Nc2ccc(Cl)cc2)C1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.O.O=C(O)c1cccc(-c2ccco2)c1>>CC(C)(C)[Si](C)(C)OC1CC(C(=O)Nc2ccc(Cl)cc2)CN(C(=O)c2cccc(-c3ccco3)c2)C1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCCNC1.CCOC(C)=O.CN(C)C=O.Nc1cncnc1Cl.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)(C)OC(=O)N[C@H]1CCCN(c2ncncc2N)C1",
        "output": "296"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NCCCCBr.CCCCc1cc(OC2CCNCC2)c2ncccc2c1>>CCCCc1cc(OC2CCN(CCCCNC(=O)OC(C)(C)C)CC2)c2ncccc2c1",
        "output": "73"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1c(NS(=O)(=O)c2ccccc2NCC2CCN(C(=O)OC(C)(C)C)CC2)ccc2c1CCCC2.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1c(NS(=O)(=O)c2ccccc2NCC2CCNCC2)ccc2c1CCCC2",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.COc1cccc2c1cc(C1CC1)n2Cc1ccccc1-c1ccccc1.ClCl>>Oc1cccc2c1cc(C1CC1)n2Cc1ccccc1-c1ccccc1",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(C)=O.Cc1ccccc1C(=O)C1CN2CCC1CC2.O.[BH4-].[Na+]>>Cc1ccccc1C(O)C1CN2CCC1CC2",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN.CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(-c3ccc(C=O)cc3)ccc2-n2c(C)nnc21.Cl.ClCCl.O=C([O-])O.[Na+].[Na+]>>CCNCc1ccc(-c2ccc3c(c2)C(c2ccc(Cl)cc2)=N[C@@H](CC(=O)NCC)c2nnc(C)n2-3)cc1",
        "output": "468"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2ccc(C#N)cn2)CC1.ClCCl.O=C(O)C(F)(F)F>>N#Cc1ccc(OC2CCNCC2)nc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CN(C)C1(c2ccccc2)CCC(NC(=O)Oc2ccccc2)CC1.c1ccc2c(C3CCNCC3)c[nH]c2c1>>CN(C)C1(c2ccccc2)CCC(NC(=O)N2CCC(c3c[nH]c4ccccc34)CC2)CC1",
        "output": "525"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CN(C)[C@H]1CCNC1.Fc1ccc(Br)cn1.O=C([O-])[O-].[K+].[K+]>>CN(C)[C@H]1CCN(c2ccc(Br)cn2)C1",
        "output": "756"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cc1cc(CN(C)C)ccc1OC1CN(C(=O)OC(C)(C)C)C1.Cl.O=CO>>Cc1cc(CN(C)C)ccc1OC1CNC1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(CO)NC(=O)OC(C)(C)C.CCOCC.ClCCl.[Na+].[OH-]>>CC(C)(C=O)NC(=O)OC(C)(C)C",
        "output": "142"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)Cc1ccc(OC)c(Oc2ccc(NC(=O)c3ccc(Cl)cc3)cc2CN(CC)C(=O)OCc2ccccc2)c1.CO.O.[Li+].[OH-]>>CCN(Cc1cc(NC(=O)c2ccc(Cl)cc2)ccc1Oc1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1cc2nccc(Cl)c2cc1OC.Nc1ccc(O)c(F)c1.[H-].[Na+]>>COc1cc2nccc(Oc3ccc(N)cc3F)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)[C@H](N)CO.O=C(NC1(C(=O)O)CCCCC1)OCc1ccco1>>CC(C)[C@@H](CO)NC(=O)C1(NC(=O)OCc2ccco2)CCCCC1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(N)CNc1c([N+](=O)[O-])c(Cl)nc2ccccc12.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)(CNc1c([N+](=O)[O-])c(Cl)nc2ccccc12)NS(C)(=O)=O",
        "output": "493"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc2c(-c3ccccc3)c(C(=O)c3ccc(Cl)cc3)sc2c1.Cl.c1ccncc1>>O=C(c1ccc(Cl)cc1)c1sc2cc(O)ccc2c1-c1ccccc1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCC(CC)CN.CCOC(=O)C(C)O>>CCCCC(CC)CNC(=O)C(C)O",
        "output": "64"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COc1ccccc1CNc1cc(=O)n(OCc2ccccc2)c2ncnc(C)c12.[C].[H][H].[OH-].[OH-].[Pd+2]>>COc1ccccc1CNc1cc(=O)n(O)c2ncnc(C)c12",
        "output": "630"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)c1sc(N2CC(NC(=O)c3nc(Cl)c(CC)[nH]3)C2)nc1C(C)C.CO.O.[Li+].[OH-]>>CCc1[nH]c(C(=O)NC2CN(c3nc(C(C)C)c(C(=O)O)s3)C2)nc1Cl",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCC.CCCCCCCCCCCCO.O=C(Cl)C1CC1.c1ccccc1>>CCCCCCCCCCCCOC(=O)C1CC1",
        "output": "126"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(Nc2ccc(-c3cnc4[nH]cc(-c5cnn(Cc6cccc(F)c6)c5)c4c3)cc2)CC1.CCOCC.CO.Cl>>Fc1cccc(Cn2cc(-c3c[nH]c4ncc(-c5ccc(NC6CCNCC6)cc5)cc34)cn2)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCO.Cc1ccc2c(O)c(Br)c(C)cc2c1.[Pd]>>Cc1ccc2c(O)cc(C)cc2c1",
        "output": "350"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CS(=O)(=O)Cl.ClCCl.c1ccncc1>>CC(C)(C)OC(=O)N1CCN(S(C)(=O)=O)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1cccc(C(=O)O)c1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCc1ccccc1.O>>CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1cccc(C(=O)NCc2ccccc2)c1",
        "output": "753"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CCO.CCOc1cc(C=O)ccc1OC.COC(=O)C(C)(C)c1ccc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)cc1.COC(=O)C(C)(C)c1ccc(C(=O)NC2CCNCC2)cc1.ClCCl.O=C(O)C(F)(F)F.[BH3-]C#N.[Na+]>>CCOc1cc(CN2CCC(NC(=O)c3ccc(C(C)(C)C(=O)OC)cc3)CC2)ccc1OC",
        "output": "567"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C=CCOC[C@H](N)c1nc2cc(Cl)ccc2[nH]1.CCN(C(C)C)C(C)C.CCO.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cc1cc(C(=O)O)ccc1C(=O)N1CC=CC1.ClCCl.ClCl.F[B-](F)(F)F>>C=CCOC[C@H](NC(=O)c1ccc(C(=O)N2CC=CC2)c(C)c1)c1nc2cc(Cl)ccc2[nH]1",
        "output": "902"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)c1cc([N+](=O)[O-])ccc1OC1CCN(C(=O)OC(C)(C)C)CC1.[K+].[OH-]>>CC(C)(C)OC(=O)N1CCC(Oc2ccc([N+](=O)[O-])cc2C(=O)O)CC1",
        "output": "5"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CCN=C=NCCCN(C)C.CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)O)cc4)cc3)nc21.NCc1ccncc1.On1nnc2ccccc21>>CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)NCc5ccncc5)cc4)cc3)nc21",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCc1ccc(F)cc1>>COc1cc2nccc(Oc3cc(C)c(NC(=O)OCc4ccc(F)cc4)cc3C)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1nc2ccc(S(C)(=O)=O)cc2nc1O.O.[K+].[OH-]>>CS(=O)(=O)c1ccc2nc(C(=O)O)c(O)nc2c1",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC(N)CCC.O=C(O)c1ccc(O)c(O)c1>>CCCC(CCC)NC(=O)c1ccc(O)c(O)c1",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1cc(C(C)C)n(Cc2ccccc2)c1C(C)C.[Na+].[OH-]>>CC(C)c1cc(C(=O)O)c(C(C)C)n1Cc1ccccc1",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN1CCNCC1.ClCCl.O=C(Cl)c1ccc(I)cc1.O=C([O-])[O-].[K+].[K+]>>CCN1CCN(C(=O)c2ccc(I)cc2)CC1",
        "output": "201"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrP(Br)Br.CCN(C(C)C)C(C)C.CCOC(=O)C1CCNCC1.CCc1nc2cc(CO)ccc2o1.Cc1ccccc1.O>>CCOC(=O)C1CCN(Cc2ccc3oc(CC)nc3c2)CC1",
        "output": "765"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.NC(=O)Cc1cc(F)ccc1CCc1nc(Nc2ccc(C3CCNCC3)cc2)ncc1C(F)(F)F.[Na+]>>CN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccc(F)cc4CC(N)=O)n3)cc2)CC1",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.Cc1ccccc1S(=O)(=O)N=C=O.Cc1nc(C)nc(N)n1>>Cc1nc(C)nc(NC(=O)NS(=O)(=O)c2ccccc2C)n1",
        "output": "566"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(C(=O)Nc2ccc(N(CCc3ccccn3)C(=O)OC(C)(C)C)cc2)c(N2CCCCC2)n1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(C(=O)Nc2ccc(NCCc3ccccn3)cc2)c(N2CCCCC2)n1",
        "output": "830"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1cc(NC(=O)c2ccc(Cl)nc2)ccc1Cl.O=C(O)c1cccc(F)c1>>O=C(Nc1ccc(Cl)c(NC(=O)c2cccc(F)c2)c1)c1ccc(Cl)nc1",
        "output": "50"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc(CNS(=O)(=O)Cc2ccc(CC(=O)O)cc2)c(OC)c1.F[P-](F)(F)(F)(F)F.O>>COc1ccc(CNS(=O)(=O)Cc2ccc(CC(=O)N3CCOCC3)cc2)c(OC)c1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br[Mg]c1ccccc1.C1CCOC1.COCCn1c(-c2ccc(C(C)C)cc2)nc2cc(C=O)cc(OC)c21>>COCCn1c(-c2ccc(C(C)C)cc2)nc2cc(C(O)c3ccccc3)cc(OC)c21",
        "output": "309"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.Fc1cc(I)ccn1.O.O=C([O-])[O-].[Cs+].[Cs+]>>COc1cc(I)ccn1",
        "output": "541"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)C=Cc1ccc(C(=O)OCc2ccccc2)o1.O=C(O)C(F)(F)F>>O=C(O)/C=C/c1ccc(C(=O)OCc2ccccc2)o1",
        "output": "158"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CS(C)=O.Cl.N#C[C@@H]1CCCN1C(=O)CCl.NC12CC3CC1CC(O)(C3)C2.O=C([O-])[O-].[K+].[K+]>>N#C[C@@H]1CCCN1C(=O)CNC12CC3CC1CC(O)(C3)C2",
        "output": "330"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N(c1cscn1)S(=O)(=O)c1cc(Cl)c(F)cc1F.CN(C)C=O.O.O=C([O-])[O-].Oc1ccc(Cl)cc1-c1cnn2c1NCCC2.[K+].[K+]>>CC(C)(C)OC(=O)N(c1cscn1)S(=O)(=O)c1cc(Cl)c(Oc2ccc(Cl)cc2-c2cnn3c2NCCC3)cc1F",
        "output": "564"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)Oc1ccc(-c2cccc(C3Nc4ccc(C(=O)O)cc4CC3(C)C)c2)cc1.CN(C)c1ccncc1.ClCCl.NS(=O)(=O)C1CC1>>CC(C)Oc1ccc(-c2cccc(C3Nc4ccc(C(=O)NS(=O)(=O)C5CC5)cc4CC3(C)C)c2)cc1",
        "output": "580"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCC(NC(C)=O)C3)nc21.Cl.[Na+].[OH-]>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCC(N)C3)nc21",
        "output": "412"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.Cn1nc(C(F)(F)C(F)(F)F)c(C(F)(F)F)c1NC(=O)c1ccc(C#N)c(Cl)n1.N.O>>Cn1nc(C(F)(F)C(F)(F)F)c(C(F)(F)F)c1NC(=O)c1ccc(C#N)c(N)n1",
        "output": "388"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1[nH]c(C=O)c2c1CCCC2.O=C1Cc2c(cccc2-c2ccncc2)N1>>CCOC(=O)c1[nH]c(C=C2C(=O)Nc3cccc(-c4ccncc4)c32)c2c1CCCC2",
        "output": "440"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCNC.O=C1CCN(c2ccc(CN3CCOCC3)cc2)CC1>>CCN(C)C1CCN(c2ccc(CN3CCOCC3)cc2)CC1",
        "output": "187"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CNC1.CCCNC(=O)c1nnc2c(-c3cccc(C(=O)O)c3)cccc2c1N.CN(C)C=O.CN1CCOCC1.O.On1nnc2ccccc21>>CCCNC(=O)c1nnc2c(-c3cccc(C(=O)N4CCC4)c3)cccc2c1N",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cc(Br)c2c(=O)[nH]cnc2c1.O=S(=O)(O)O.O=[N+]([O-])O>>Cc1cc(Br)c2c(=O)[nH]cnc2c1[N+](=O)[O-]",
        "output": "328"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.Cc1cccc(C)c1C=O.O=c1[nH]c2ccccc2n1C1CCN(C2CCNCC2)CC1.[BH3-]C#N.[Cl-].[Cl-].[Na+].[Zn+2]>>Cc1cccc(C)c1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.CCN(C(C)C)C(C)C.Cc1ccc(C(=O)CBr)cc1.ClCCl>>Cc1ccc(C(=O)COC(=O)[C@@H]2CCCN2C(=O)OC(C)(C)C)cc1",
        "output": "523"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.CCn1c(=O)c(=O)[nH]c2ccc(N)cc21>>CCn1c(=O)c(=O)[nH]c2ccc(NC(C)=O)cc21",
        "output": "6"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[Si](C)(C)Oc1cccc(-c2ccccc2[N+](=O)[O-])c1.CCO>>CC(C)(C)[Si](C)(C)Oc1cccc(-c2ccccc2N)c1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)c1ccc(N)cc1.CSc1ccc(C=O)cc1>>CSc1ccc(CNc2ccc(C(C)C)cc2)cc1",
        "output": "359"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CNc1ncnc2ccc(C=O)cc12.O=C1CSC(=O)N1>>CNc1ncnc2ccc(C=C3SC(=O)NC3=O)cc12",
        "output": "761"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CC(=O)[O-].CC(=O)[O-].CCOC(=O)c1n[nH]cc1C.COc1cccc(B(O)O)c1.[Cu+2].c1ccncc1>>CCOC(=O)c1nn(-c2cccc(OC)c2)cc1C",
        "output": "925"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCBr.CN(C)C=O.O=C([O-])[O-].O=Cc1cc(Br)ccc1O.[Cl-].[K+].[K+].[NH4+]>>O=Cc1cc(Br)ccc1OCCBr",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCC1CC1.C1CCOC1.CC1CC=CCC1CO.[NH2-].[Na+]>>CC1CC=CCC1COCC1CC1",
        "output": "95"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C1CCc2[nH]c3ccc(N)cc3c2C1.O=C(O)c1ccncc1>>CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccncc4)cc3c2C1",
        "output": "50"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCc1nc2ccccc2n1Cc1ccc(-c2cc(Cl)ccc2C(=O)OC(C)(C)C)cc1.O=C(O)C(F)(F)F>>CCCCc1nc2ccccc2n1Cc1ccc(-c2cc(Cl)ccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.COc1cc(CO)ccc1C(=O)CNCCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1.CS(C)=O.ClCCl>>COc1cc(C=O)ccc1C(=O)CNCCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1",
        "output": "179"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccccc1C.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COc1ccc(Br)cc1C",
        "output": "4"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.COc1c(C(C)C)cccc1C(C)(C)CC(O)(CO)C(F)(F)F.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl>>COc1c(C(C)C)cccc1C(C)(C)CC(O)(C=O)C(F)(F)F",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)c1cc2cc(Br)cnc2n1C.[AlH4-].[Li+]>>Cn1c(CO)cc2cc(Br)cnc21",
        "output": "546"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCc1ccc(C=CC2CCC(=O)CC2)cc1.CCO.Cc1ccccc1.[H][H].[Pd]>>CCCc1ccc(CCC2CCC(=O)CC2)cc1",
        "output": "362"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.ClCc1ccc2c(c1)OCO2.N#Cc1ccc(O)cc1F.O=C([O-])[O-].[K+].[K+]>>N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1F",
        "output": "49"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1c(F)cccc1C(=O)Nc1ccc(C(=O)O)c(Cl)c1.O=S(Cl)Cl>>Cc1c(F)cccc1C(=O)Nc1ccc(C(=O)Cl)c(Cl)c1",
        "output": "3"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CN(C)C=O.Cc1cc([N+](=O)[O-])cnc1Cl.O=C([O-])[O-].O=C1N([C@H]2CC[C@@H](O)CC2)CCC12CCNCC2.[K+].[K+]>>Cc1cc([N+](=O)[O-])cnc1N1CCC2(CC1)CCN([C@H]1CC[C@@H](O)CC1)C2=O",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.Nc1cc(Cl)ccc1OC1CCC(O)CC1.O=C(O)c1cnn2cccnc12>>O=C(Nc1cc(Cl)ccc1OC1CCC(O)CC1)c1cnn2cccnc12",
        "output": "969"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc([N+](=O)[O-])cc1F.[H][H].[Ni]>>COC(=O)c1ccc(N)cc1F",
        "output": "772"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CS(C)=O.Nc1nccs1.O=C1[C@@H](N2CC[C@H](c3cc(Cl)cc(Cl)c3)C2)CCN1c1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>O=C1[C@@H](N2CC[C@H](c3cc(Cl)cc(Cl)c3)C2)CCN1c1ccc(S(=O)(=O)Nc2nccs2)cc1",
        "output": "637"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1ccc(O)cc1.CC(C)=O.ClCc1ccccc1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CC(=O)c1ccc(OCc2ccccc2)cc1",
        "output": "49"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.O=[N+]([O-])c1ccc(N2CC[C@@H](O)C2)nc1.[OH-].[OH-].[Pd+2]>>Nc1ccc(N2CC[C@@H](O)C2)nc1",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "B.C1CCOC1.C1CCOC1.O=C(O)CCCCCCCCCCCc1cccc(I)c1>>OCCCCCCCCCCCCc1cccc(I)c1",
        "output": "231"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.CN(C)CCCl.Cc1ccc2c(I)n[nH]c2c1.Cl.O.O=C([O-])[O-].[K+].[K+]>>Cc1ccc2c(I)nn(CCN(C)C)c2c1",
        "output": "604"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CCC1CCN(CCN)CC1.CCOC(C)=O.O=C1Nc2cccnc2N(C(=O)Cl)c2ccccc21>>CCN(CC)CCC1CCN(CCNC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1",
        "output": "454"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)N1CCC(N)CC1.CC(C)c1nc(-c2ccc(F)c(NS(=O)(=O)c3cc(F)ccc3F)c2)c(-c2ccnc(Cl)n2)s1>>CC(=O)N1CCC(Nc2nccc(-c3sc(C(C)C)nc3-c3ccc(F)c(NS(=O)(=O)c4cc(F)ccc4F)c3)n2)CC1",
        "output": "544"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cc1ccc([N+](=O)[O-])c(Nc2ccc(CCO)cc2)n1.[Pd]>>Cc1ccc(N)c(Nc2ccc(CCO)cc2)n1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.ClCCl.NCc1ccc(Cc2ccc(OC(F)F)c(-c3cccc(Cl)c3)c2)cn1.O=C(Cl)Oc1ccccc1>>O=C(NCc1ccc(Cc2ccc(OC(F)F)c(-c3cccc(Cl)c3)c2)cn1)Oc1ccccc1",
        "output": "94"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COc1nc(Cl)cc(Cl)n1.NCC1OCCc2ccccc21.O.O=C([O-])O.[Na+]>>COc1nc(Cl)cc(NCC2OCCc3ccccc32)n1",
        "output": "166"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1ccc(-c2cc3ccccc3[nH]2)cc1N.ClCCl.O=C([O-])O.O=Cc1ccc(O)c([N+](=O)[O-])c1.[Na+].[Na+]>>COc1ccc(-c2cc3ccccc3[nH]2)cc1NCc1ccc(O)c([N+](=O)[O-])c1",
        "output": "359"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)CCc1ccc(OCCO[Si](C(C)C)(C(C)C)C(C)C)cc1Oc1ncc(C(F)(F)F)cc1Cl.CCOCC.Cc1ccccc1.O.[Cl-].[H-].[Na+]>>CC(C)[Si](OCCOc1ccc(CCCO)c(Oc2ncc(C(F)(F)F)cc2Cl)c1)(C(C)C)C(C)C",
        "output": "225"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrBr.CO.C[O-].Cc1ccc([N+](=O)[O-])c(O)n1.[Na+]>>Cc1nc(O)c([N+](=O)[O-])cc1Br",
        "output": "292"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCO.COc1cccc(F)c1C#N.NN.O.O>>COc1cccc2[nH]nc(N)c12",
        "output": "945"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "O=C(O)CSc1nc2ccccc2s1.c1ccc2c(c1)NCCN2>>O=C(CSc1nc2ccccc2s1)N1CCNc2ccccc21",
        "output": "315"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCCCC1.CCOC(C)=O.CN1CCN(CCCC2CCNCC2)CC1.CO.N.O=C1Nc2cccnc2N(C(=O)Cl)c2ccccc21>>CN1CCN(CCCC2CCN(C(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)CC1",
        "output": "258"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COCC(C)Nc1cc(-c2ccnc(Cl)n2)ncn1.Cc1ccc(S(=O)(=O)O)cc1.Nc1cccc(Cl)c1.O>>COCC(C)Nc1cc(-c2ccnc(Nc3cccc(Cl)c3)n2)ncn1",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.COC[C@H](C)Oc1cc(Oc2ccc3c(c2)OCCN(C)C3=O)cc(C(=O)Nc2cnc(C)cn2)c1.C[Si](C)(C)I.O=C([O-])O.[Na+]>>Cc1cnc(NC(=O)c2cc(Oc3ccc4c(c3)OCCN(C)C4=O)cc(O[C@@H](C)CO)c2)cn1",
        "output": "423"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC(=O)NCC(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.Cl.O.O=C1CCNCC1c1ccccc1.[Cl-].[Na+]>>CC(=O)NCC(=O)N1CCC(=O)C(c2ccccc2)C1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)O.CN1C(=O)C(F)(F)CNc2nc(Cl)ncc21.COc1cc(C(=O)NC2CCN(C)CC2)ccc1N.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O.O=C([O-])[O-].[Na+].[Na+]>>COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)NCC(F)(F)C(=O)N2C",
        "output": "941"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(O)CN.Cc1ccccc1.O.O=C(O)Cc1ccc(Cl)cc1.OB(O)O.OB(O)c1ccccc1>>CC(O)CNC(=O)Cc1ccc(Cl)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCCCC1.CCOC(C)=O.COc1ccc(B(O)O)cc1.O=c1ccc(Br)c[nH]1>>COc1ccc(-c2ccc(=O)[nH]c2)cc1",
        "output": "833"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.ClCCl.NC1CCN(C2CCOCC2)CC1.O=[N+]([O-])c1ccc(Br)cc1F>>O=[N+]([O-])c1ccc(Br)cc1NC1CCN(C2CCOCC2)CC1",
        "output": "572"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].COC(=O)c1ccc(Br)c(OCCF)n1.Cl.FC1(F)CNC1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COC(=O)c1ccc(N2CC(F)(F)C2)c(OCCF)n1",
        "output": "597"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN1CCNCC1.COc1ccc(CN(Cc2ccc(OC)cc2)c2ncc(-c3nc(N4CCOCC4)nc4c3CCN4c3ccc(C=O)cc3)cn2)cc1.ClCCl.[Cl-].[NH4+].[Na+]>>COc1ccc(CN(Cc2ccc(OC)cc2)c2ncc(-c3nc(N4CCOCC4)nc4c3CCN4c3ccc(CN4CCN(C)CC4)cc3)cn2)cc1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1onc(-c2ccccc2)c1COc1cc(C(=O)O)ccn1.Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)O)cn1.NCC(F)(F)F>>Cc1onc(-c2ccccc2)c1COc1cc(C(=O)NCC(F)(F)F)ccn1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)c1cccnc1C.Cc1ccccc1.Cl.[H-].[Na+].[OH-]>>Cc1ncccc1CO",
        "output": "383"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CCN(c2ccc(N)cc2)CC1.O=C(O)COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1>>CN1CCN(c2ccc(NC(=O)COc3ccc(C45CC6CC(CC(C6)C4)C5)cc3)cc2)CC1",
        "output": "365"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1cc(Br)ncc1[N+](=O)[O-].O.[Cl-].[Fe].[NH4+]>>Cc1cc(Br)ncc1N",
        "output": "269"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(=O)c1ccc(O)cc1.CCOC(=O)CBr.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)COc1ccc(C(=O)CC)cc1",
        "output": "123"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCN(Cc1cc(C(=O)OCCCN2CCN(CCO)CC2)cc(Br)c1N)C1CCCCC1.O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl>>CCN(Cc1cc(C(=O)OCCCN2CCN(CCOC(=O)Cc3ccccc3Nc3c(Cl)cccc3Cl)CC2)cc(Br)c1N)C1CCCCC1",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.NC(=O)c1ccc(F)c2c1CC([N+](=O)[O-])CO2.[Ni]>>NC(=O)c1ccc(F)c2c1CC(N)CO2",
        "output": "226"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Cl.CCN(C(C)C)C(C)C.CN(C)C=O.Cl.N#Cc1ccc(N2C3CCC2CC(N)C3)c2ccccc12.O>>CC(=O)NC1CC2CCC(C1)N2c1ccc(C#N)c2ccccc12",
        "output": "45"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1ccc(/C=C/C(c2c3c(nn2-c2ccc(Cl)cc2)CCCC3)C2CCCCC2)cc1.[Na+].[OH-]>>O=C(O)c1ccc(/C=C/C(c2c3c(nn2-c2ccc(Cl)cc2)CCCC3)C2CCCCC2)cc1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(=O)(=O)Cl.ClCCl.OC1CCOC(c2ncc(Br)cc2Cl)C1>>CS(=O)(=O)OC1CCOC(c2ncc(Br)cc2Cl)C1",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClC(Cl)Cl.O=S(Cl)Cl.O=[N+]([O-])c1cc(C(F)(F)F)ccc1NCCO>>O=[N+]([O-])c1cc(C(F)(F)F)ccc1NCCCl",
        "output": "96"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.CCN(C(C)C)C(C)C.COC(=O)/C=C/C(=O)OCC(=O)N1CCNCC1.Cl.ClCCl>>COC(=O)/C=C/C(=O)OCC(=O)N1CCN(C(C)=O)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C1c2ccccc2C(=O)c2c1cccc2[N+](=O)[O-].[H][H].[Na+].[Ni].[OH-]>>Nc1cccc2c1C(=O)c1ccccc1C2=O",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)NC1CNC1.CCc1cc(Br)ncc1[N+](=O)[O-].CN(C)C=O.Cl.O.O=C([O-])[O-].[K+].[K+]>>CCc1cc(N2CC(NC(=O)OC(C)(C)C)C2)ncc1[N+](=O)[O-]",
        "output": "647"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.CCCCCC.Cc1cc(OC2CCSCC2)cc(C)c1Br.Cl.[Li]CCCC>>Cc1cc(OC2CCSCC2)cc(C)c1B(O)O",
        "output": "832"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCOC(=O)CC(c1ccccc1)c1c[nH]c2cc(O)ccc12.O=C([O-])[O-].OCCCCBr.[K+].[K+]>>CCOC(=O)CC(c1ccccc1)c1c[nH]c2cc(OCCCCO)ccc12",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2oc3ccc(OCCSC)cc3c2C)C2CCCCC2)cc1.[Na+].[OH-]>>CSCCOc1ccc2oc(C(Nc3ccc(C(=O)N(C)CCC(=O)O)cc3)C3CCCCC3)c(C)c2c1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1cccc2c1C1CCC2C1.C1CCOC1.COB(OC)OC.COC(C)(C)C.Cl.[Li]CCCC>>OB(O)c1cccc2c1C1CCC2C1",
        "output": "789"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)O.COc1cc(N2CCC(N3CCN(CCS(C)(=O)=O)CC3)CC2)ccc1N.Cc1ccc(S(=O)(=O)O)cc1.O=C(Nc1c(F)cccc1F)c1cccc(-c2nc3ccccn3c2-c2ccnc(Cl)n2)c1>>COc1cc(N2CCC(N3CCN(CCS(C)(=O)=O)CC3)CC2)ccc1Nc1nccc(-c2c(-c3cccc(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1",
        "output": "808"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CN(c1ccc(F)c([N+](=O)[O-])c1)S(=O)(=O)c1ccccc1.NCC1CCCC1>>CN(c1ccc(NCC2CCCC2)c([N+](=O)[O-])c1)S(=O)(=O)c1ccccc1",
        "output": "572"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1c(Cl)ccc(-c2nc(O)c(Cl)c(C(=O)O)n2)c1F.O.O=P(Cl)(Cl)Cl>>COc1c(Cl)ccc(-c2nc(Cl)c(Cl)c(C(=O)O)n2)c1F",
        "output": "168"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=[N+]([O-])c1cccc(-c2ncnc3[nH]cc(Br)c23)c1.[Pt]>>Nc1cccc(-c2ncnc3[nH]cc(Br)c23)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)Cc1nnc(S)o1.N>>NC(=O)Cc1nnc(S)o1",
        "output": "163"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CN2CCN1CC2.CS(C)=O.O=C(O)c1cn(C2CC2)c2cc(Cl)c(F)cc2c1=O.c1ccc(C2CNCCN2)cc1>>O=C(O)c1cn(C2CC2)c2cc(N3CCNC(c4ccccc4)C3)c(F)cc2c1=O",
        "output": "280"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](C)(C)OCc1csc(C(=O)c2cncnc2Cl)c1.CCO.Cl>>O=C(c1cc(CO)cs1)c1cncnc1Cl",
        "output": "708"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CO.Cl[Sn]Cl.[N-]=[N+]=NCc1ccc(COc2ccc(Cl)cc2)cc1>>NCc1ccc(COc2ccc(Cl)cc2)cc1",
        "output": "562"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)(C)[Si](OCc1cccc(N)c1)(c1ccccc1)c1ccccc1.CCN(CC)CC.CCOC(=S)c1cnc(C)nc1Cl>>CCOC(=S)c1cnc(C)nc1Nc1cccc(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c1",
        "output": "161"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)Nc1ccc2c(c1[N+](=O)[O-])CCC2Nc1ccc(F)cc1.CO.[Ni]>>CCOC(=O)Nc1ccc2c(c1N)CCC2Nc1ccc(F)cc1",
        "output": "71"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)C1=C(c2ccc(CCCOc3c(F)ccc(F)c3Cl)cc2)C(F)(F)CN(C(=O)OC(C)(C)C)C1.Cl.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CC(C(=O)O)=C(c2ccc(CCCOc3c(F)ccc(F)c3Cl)cc2)C(F)(F)C1",
        "output": "122"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "B.C1CCOC1.C1CCOC1.CCOC(C)=O.O.O=C(O)c1ccc(Cl)nc1Cl.O=C([O-])[O-].[K+].[K+]>>OCc1ccc(Cl)nc1Cl",
        "output": "293"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(=O)c1ccnc2ccc(Br)cc12.CN(C)C=O.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)c1ccnc2ccc(B3OC(C)(C)C(C)(C)O3)cc12",
        "output": "942"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#CCCO.CCN(CC)CC.Fc1ccc(Br)cc1.[Cl-].[Cu]I.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc([P]([Pd][P](c2ccccc2)(c2ccccc2)c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>OCCC#Cc1ccc(F)cc1",
        "output": "659"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)Cc1ccncc1[N+](=O)[O-].[Pd]>>CCOC(=O)Cc1ccncc1N",
        "output": "269"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1cncc(COCC2(c3ccccc3)CCNCC2)c1.N#Cc1ccc(B(O)O)cc1.O=C(O)C(F)(F)F>>N#Cc1ccc(-c2cncc(COCC3(c4ccccc4)CCNCC3)c2)cc1",
        "output": "833"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCC(CC)CN.Cc1nc(Cl)c2nc(-c3ccccc3)cc-2[nH]1.O.O=C([O-])[O-].[K+].[K+]>>CCCCC(CC)CNc1nc(C)[nH]c2cc(-c3ccccc3)nc1-2",
        "output": "148"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N(c1cc(Cl)nc2c(C=O)cnn12)C1CC1.CC(C)(C)[O-].N#Cc1ccc(N)c(Br)c1.O.[Na+]>>CC(C)(C)OC(=O)N(c1cc(Nc2ccc(C#N)cc2Br)nc2c(C=O)cnn12)C1CC1",
        "output": "161"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.C[Si](C)(C)C=[N+]=[N-].ClCCl.O.O=C(O)c1cc(F)c(F)cc1NC1CC1.O=CO>>COC(=O)c1cc(F)c(F)cc1NC1CC1",
        "output": "195"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Clc1ccc2c(c1)Cc1ccccc1[C@@H]1CNCCN21.O=C1c2ccccc2C(=O)N1CCBr>>O=C1c2ccccc2C(=O)N1CCN1CCN2c3ccc(Cl)cc3Cc3ccccc3[C@@H]2C1",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCO/N=C(\\c1ccc(Br)cc1)C1CCN(C2(C)CCNCC2)CC1.CCn1ccc2c(C(=O)O)cccc21.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F>>CCO/N=C(\\c1ccc(Br)cc1)C1CCN(C2(C)CCN(C(=O)c3cccc4c3ccn4CC)CC2)CC1",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.Cl.ClCCl.O=C(/C=C/c1ccc2c(c1)C(=O)CC1(CN(CCc3ccccc3)C1)O2)NOC1CCCCO1>>O=C(/C=C/c1ccc2c(c1)C(=O)CC1(CN(CCc3ccccc3)C1)O2)NO",
        "output": "915"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)C(=O)NCc1cnc(C(F)F)c(C(=O)O)c1.CC(C)Nc1ncnc2c(N)cccc12.CCN(C(C)C)C(C)C.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)Nc1ncnc2c(NC(=O)c3cc(CNC(=O)C(C)C)cnc3C(F)F)cccc12",
        "output": "863"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)[C@](O)(c1ccc(F)cc1)C(F)(F)F.Cl.[Na+].[OH-]>>O=C(O)[C@](O)(c1ccc(F)cc1)C(F)(F)F",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CC(=O)Cl.ClCCl.N#Cc1ccc(C2CCNCC2)nc1-c1ccc(Oc2ccccc2)cc1>>C=CC(=O)N1CCC(c2ccc(C#N)c(-c3ccc(Oc4ccccc4)cc3)n2)CC1",
        "output": "135"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCCl.ClCCl.NCCCCNC(=O)[C@@H]1C[C@H]1c1ccccc1.O=C(O)C=Cc1cccnc1.On1nnc2ccccc21>>O=C(C=Cc1cccnc1)NCCCCNC(=O)[C@@H]1C[C@H]1c1ccccc1",
        "output": "549"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)C(=O)c1ccc(OCOc2ccccc2)cc1.[Na+].[OH-]>>O=C(O)C(=O)c1ccc(OCOc2ccccc2)cc1",
        "output": "506"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CBr.CN(C)C=O.O=C(c1cnccc1Oc1cc(Cl)c(O)cc1Cl)N1CCN(C2CC2)c2ccccc21.[H-].[Na+]>>CCOC(=O)COc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl",
        "output": "123"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1c(C=O)[nH]c2c1C(=O)N(CCN1CCCC1)CC2.O=C(CO)Nc1cc2c(cc1F)CC(=O)N2>>Cc1c(C=C2C(=O)Nc3cc(NC(=O)CO)c(F)cc32)[nH]c2c1C(=O)N(CCN1CCCC1)CC2",
        "output": "440"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccc2c(c1)c1ccccc1n2-c1ccccc1.CC(C)(C)[O-].Cc1ccccc1.Cc1ccccc1C.Nc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Fe+2].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccc[cH-]2)cc1.c1ccc(P(c2ccccc2)c2ccc[cH-]2)cc1>>c1ccc(Nc2ccc3c(c2)c2ccccc2n3-c2ccccc2)cc1",
        "output": "405"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COc1ccc2nccc([C@@H]3CN(C[C@@H](O)CN)C(=O)O3)c2n1.ClC(Cl)Cl.ClCCl.O=Cc1ccc2c(n1)NC(=O)CS2.[BH4-].[Na+]>>COc1ccc2nccc([C@@H]3CN(C[C@@H](O)CNCc4ccc5c(n4)NC(=O)CS5)C(=O)O3)c2n1",
        "output": "775"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(C)(c2cc3cc(Cl)ncc3o2)CC1.CS(=O)(=O)c1ccc(B(O)O)cc1>>CC(C)(C)OC(=O)N1CCC(C)(c2cc3cc(-c4ccc(S(C)(=O)=O)cc4)ncc3o2)CC1",
        "output": "865"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COCCOC.Cl[Pd]Cl.Nc1cc(Br)cc(N)n1.O=C([O-])[O-].OB(O)c1ccc(Cl)c(Cl)c1.[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)c2cc[cH-]c2)cc1.c1ccc(P(c2ccccc2)c2cc[cH-]c2)cc1>>Nc1cc(-c2ccc(Cl)c(Cl)c2)cc(N)n1",
        "output": "872"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(C)=O.Cc1c(Cl)ccnc1C(O)C1CC1.ClCCl.O.O=C(Cl)C(=O)Cl>>Cc1c(Cl)ccnc1C(=O)C1CC1",
        "output": "456"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cc(F)ccc1C(=O)O.Cl.Fc1ccccc1-c1nc(C2CCCNC2)no1>>Cc1cc(F)ccc1C(=O)N1CCCC(c2noc(-c3ccccc3F)n2)C1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNCC1.CCN(CC)CCN1CCc2[nH]c(C=O)c(C)c2C1=O.CCO.O=C1Cc2cc(F)ccc2N1>>CCN(CC)CCN1CCc2[nH]c(C=C3C(=O)Nc4ccc(F)cc43)c(C)c2C1=O",
        "output": "440"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.Nc1cccc(N)n1.O=C(Cl)c1c(Cl)cccc1Cl>>Nc1cccc(NC(=O)c2c(Cl)cccc2Cl)n1",
        "output": "463"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.O=C(O)c1ccc(O)c(C(=O)O)c1.O=C([O-])O.O=S(=O)(O)O.[Na+]>>CCOC(=O)c1ccc(O)c(C(=O)O)c1",
        "output": "33"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N(Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)nc1)C1CCN(C(=O)OC(C)(C)C)CC1.CCOC(C)=O.CCOC(C)=O.Cl>>CC(=O)N(Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)nc1)C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(C(=O)OC)c1ccccc1SCC(=O)OC(C)(C)C.CCCS.CN(C)P(=O)(N(C)C)N(C)C.[H-].[Li+]>>CCC(C(=O)O)c1ccccc1SCC(=O)OC(C)(C)C",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCn1cc(C(=O)O)c(=O)c2cc(F)c(Cl)cc21.Cc1c(C2CNCCN2)sc2ccc(Cl)cc12.c1ccncc1>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(c4sc5ccc(Cl)cc5c4C)C3)cc21",
        "output": "280"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1ccc(NC(=O)OCc2ccccc2)c(OC(F)(F)F)c1.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>O=C(Nc1ccc(CO)cc1OC(F)(F)F)OCc1ccccc1",
        "output": "444"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)CCn1ccc2c(C(=O)N3CC4(C)CC3CC(C)(C)C4)cccc21.Cl.[Na+].[OH-]>>CC1(C)CC2CC(C)(CN2C(=O)c2cccc3c2ccn3CCC(=O)O)C1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.C[C@@H](CC(=O)O)NC(=O)OC(C)(C)C.C[Si](C)(C)C=[N+]=[N-].Cc1ccccc1>>COC(=O)C[C@H](C)NC(=O)OC(C)(C)C",
        "output": "195"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1cc(-c2c(C3CC3)cnn2C)cs1.[Na+].[OH-]>>Cn1ncc(C2CC2)c1-c1csc(C(=O)O)c1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.COc1ccc(C2C(=O)NCCN2C(=O)CCl)cc1OC.Cc1ccccc1>>COc1ccc(C2C(=O)NCCN2C(=O)CN2CCOCC2)cc1OC",
        "output": "340"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CSc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1C(=O)Cl.Cc1ccccc1.OC1CCOC1>>CSc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1C(=O)OC1CCOC1",
        "output": "51"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCCN.O=C1CCCC1.[OH-].[OH-].[Pd+2]>>CC(C)(C)OC(=O)NCCNC1CCCC1",
        "output": "236"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(Br)ccc1O.Cl.ClCCN1CCCC1>>COc1cc(Br)ccc1OCCN1CCCC1",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCC3CC(C)=NO3)CC2)c2ncnn12.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n([C@@H]2CC[C@@H](OCC3CC(C)=NO3)CC2)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.OCCc1cccc(C2COC2)c1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCCc2cccc(C3COC3)c2)cc1",
        "output": "197"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.ClCCl.F[B-](F)(F)F.Nc1nc(C(=O)O)c(-c2cccc(F)c2)s1.O=C(NC[C@@H]1C[C@@H]2C[C@@H]2N1)C(F)(F)F>>Nc1nc(C(=O)N2[C@H](CNC(=O)C(F)(F)F)C[C@@H]3C[C@@H]32)c(-c2cccc(F)c2)s1",
        "output": "747"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)c1cc2c(Nc3ccc(-c4ccsc4)cc3)cncc2s1.[NH4+].[OH-]>>O=C(O)c1cc2c(Nc3ccc(-c4ccsc4)cc3)cncc2s1",
        "output": "569"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccc(-c2ccc(C(=O)O)cc2)cc1C.NCCCCCCc1cccnc1>>Cc1ccc(-c2ccc(C(=O)NCCCCCCc3cccnc3)cc2)cc1C",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@@H]1CNC[C@H]2Cc3ccc(C(F)(F)F)cc3N21.ClCCl>>C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3ccc(C(F)(F)F)cc3N21",
        "output": "694"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1nc2c(ccn2Cc2cccc(F)c2F)c(I)c1CO.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>Cc1nc2c(ccn2Cc2cccc(F)c2F)c(I)c1C=O",
        "output": "520"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC(N)CC(F)(F)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)O)n2c1.F[P-](F)(F)(F)(F)F.O>>Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)NC3CN(C(=O)OC(C)(C)C)CC(F)(F)C3)n2c1",
        "output": "697"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@@H]1CCc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>c1ccc(CC[C@H]2CCCN2)cc1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.COCC1(CN[C@@H]2C[C@H]2c2ccccc2)CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COCC1(CN(C(=O)C(F)(F)F)[C@@H]2C[C@H]2c2ccccc2)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "397"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.CSc1cc(F)ccc1C#N.Cl.O>>CSc1cc(F)ccc1CN",
        "output": "175"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.NC[C@H]1COc2cc(O)ccc2O1.O=c1ccc2ccc(OCCCCl)cc2o1.[I-].[Na+]>>O=c1ccc2ccc(OCCCNC[C@H]3COc4cc(O)ccc4O3)cc2o1",
        "output": "279"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1ncnc2c1c(O)c(-c1ccccc1)c(=O)n2OCc1ccccc1.[C].[H][H].[Pd]>>Cc1ncnc2c1c(O)c(-c1ccccc1)c(=O)n2O",
        "output": "630"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)N.CCO.O=C(c1ccc(OCC2CO2)cc1)c1cccc2[nH]ccc12>>CC(C)(C)NCC(O)COc1ccc(C(=O)c2cccc3[nH]ccc23)cc1",
        "output": "16"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCN1CCC(c2ccccc2)CC1.CCOC(C)=O.ClCCl.II.O=S(=O)([O-])C(F)(F)F.[Ag+]>>CCN1CCC(c2ccc(I)cc2)CC1",
        "output": "372"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1cc(N2CCOCC2)cc2c1nc(C)n2Cc1ccc(C)c(C)c1.[Li+].[OH-]>>Cc1ccc(Cn2c(C)nc3c(C(=O)O)cc(N4CCOCC4)cc32)cc1C",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.O=C(Nc1cn(C2CCCCO2)nc1CO)OCc1ccccc1.O=[Mn]=O>>O=Cc1nn(C2CCCCO2)cc1NC(=O)OCc1ccccc1",
        "output": "573"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCOC(C)=O.COC(=O)c1cc([N+](=O)[O-])nn1CC(=O)OC(C)(C)C.[H][H].[Pd]>>COC(=O)c1cc(N)nn1CC(=O)OC(C)(C)C",
        "output": "684"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.ClCC1CO1.N#Cc1ccc(Cl)cc1O.O=C([O-])[O-].[K+].[K+]>>N#Cc1ccc(Cl)cc1OCC1CO1",
        "output": "15"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCCCCCCNC(=O)c1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(O)C(F)(F)F>>NCCCCCCNC(=O)c1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCNCc1noc([C@H](CCCC2CCCCC2)CC(=O)OC(C)(C)C)n1.ClCCl.O=C(O)C(F)(F)F>>CCNCc1noc([C@H](CCCC2CCCCC2)CC(=O)O)n1",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].CCC1(CC)C(=O)Nc2ccccc21.ClC(Cl)Cl.[Na+]>>CCC1(CC)C(=O)Nc2ccc(Br)cc21",
        "output": "98"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)CCNC(=O)c1ccc(N2CCC(N)C2)nn1.NC1C2CN(c3ccc(C(=O)NCCC4CC4)nn3)CC12.O=C(Cl)c1ccccc1C(F)(F)F>>CC(C)CCNC(=O)c1ccc(N2CCC(NC(=O)c3ccccc3C(F)(F)F)C2)nn1",
        "output": "271"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.N#Cc1cccc(-c2nc(N)c3cc(C(O)CO)sc3n2)c1>>CS(=O)(=O)OCC(O)c1cc2c(N)nc(-c3cccc(C#N)c3)nc2s1",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrP(Br)Br.COC1CCC(CO)CC1.ClC(Cl)(Cl)Cl>>COC1CCC(CBr)CC1",
        "output": "301"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.O=C(O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1.O=S(=O)(O)O>>CCOC(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1",
        "output": "17"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.CO.ClCCl.O=C(Cl)C(=O)Cl.O=C(NC1=N[C@@]2(c3ccc(F)cc3F)CO[C@@H](C(=O)O)C[C@H]2CS1)c1ccccc1>>COC(=O)[C@H]1C[C@H]2CSC(NC(=O)c3ccccc3)=N[C@@]2(c2ccc(F)cc2F)CO1",
        "output": "195"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.Cl.ClCCl.O=C(O)CN1CCCC(c2ccccc2)(c2ccccc2)C1=O.O=C(OCc1ccccc1)N1CCNCC1>>O=C(CN1CCCC(c2ccccc2)(c2ccccc2)C1=O)N1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(C(=O)Nc2ccc(OCC(=O)O)nc2C(=O)NCC2CCOCC2)c2ccccc12.[Cl-].[NH4+]>>Cc1ccc(C(=O)Nc2ccc(OCC(N)=O)nc2C(=O)NCC2CCOCC2)c2ccccc12",
        "output": "313"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1ccc(Cl)c2c1CC(OC)O2.CO.O.[Na+].[OH-]>>COC1Cc2c(C(=O)O)ccc(Cl)c2O1",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NCC1CCN(Cc2cc(-c3ccccc3)no2)CC1.Nc1cc(C(=O)O)nc2ccccc12>>Nc1cc(C(=O)NCC2CCN(Cc3cc(-c4ccccc4)no3)CC2)nc2ccccc12",
        "output": "137"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(=O)(=O)CC(N)=NO.N#CC1CCN(C(=O)N2CC(C(=O)O)CC(c3ccc(C(F)(F)F)cc3)C2)CC1>>CS(=O)(=O)Cc1noc(C2CC(c3ccc(C(F)(F)F)cc3)CN(C(=O)N3CCC(C#N)CC3)C2)n1",
        "output": "728"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cc1c(C(=O)O)c2ccccc2n1C(=O)c1ccccc1.Cc1cc(C)c(CN)c(O)n1.Cl.ClCCl>>Cc1cc(C)c(CNC(=O)c2c(C)n(C(=O)c3ccccc3)c3ccccc23)c(O)n1",
        "output": "674"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cnn(-c2ccc(OCc3ccccc3)c(C#N)n2)c1.[Pd]>>CCOC(=O)c1cnn(-c2ccc(O)c(C#N)n2)c1",
        "output": "264"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCCc1ccccc1.COc1ccc(N2CCNCC2)cc1.CS(=O)(=O)OCCCC1CCCCC1.Cl.Cl.Fc1cc(N2CCNCC2)ccc1OCc1ccccc1>>Fc1cc(N2CCN(CCCC3CCCCC3)CC2)ccc1OCc1ccccc1",
        "output": "496"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC1Oc2c(C(=O)O)cccc2C1C.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CNC1CCCCC1.On1nnc2ccccc21>>CC1Oc2c(C(=O)N(C)C3CCCCC3)cccc2C1C",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CO.ClCCl.Nc1cc(O)c2c(c1)C(=O)c1cccc(O)c1C2=O.O.O=C(Br)CBr>>O=C(CBr)Nc1cc(O)c2c(c1)C(=O)c1cccc(O)c1C2=O",
        "output": "442"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOCC.ClCCl.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc2ccoc2c1>>O=S(=O)(Oc1ccc2ccoc2c1)C(F)(F)F",
        "output": "843"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CN([C@H](CO)CCCN)S(=O)(=O)c1ccc(N)cc1.O=C(O)[C@H](Cc1cccc2ccccc12)NC(=O)N1CCOCC1>>CC(C)CN([C@H](CO)CCCNC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)N1CCOCC1)S(=O)(=O)c1ccc(N)cc1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CCCl.CN(C)CCCOc1ccc(-c2cnc(Nc3ccccc3)s2)cc1.Cl.Oc1ccc(Nc2ncc(-c3cccc(Br)c3)s2)cc1>>CCN(CC)CCOc1ccc(Nc2ncc(-c3cccc(Br)c3)s2)cc1",
        "output": "74"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.Cc1c(N)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12.Cl.ClCCl.O=S(=O)(Cl)c1ccccc1>>Cc1c(NS(=O)(=O)c2ccccc2)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12",
        "output": "554"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Nc1nc(O)c2cc(C=Cc3ccc(C(=O)O)cc3)cnc2n1.CCOC(=O)CC[C@H](N)C(=O)OCC.CN1CCCC1=O.CN1CCOCC1.Cl.O=P(Cl)(Nc1ccccc1)Oc1ccccc1>>CCOC(=O)CC[C@H](NC(=O)c1ccc(C=Cc2cnc3nc(NC(C)=O)nc(O)c3c2)cc1)C(=O)OCC",
        "output": "709"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCc1cc(C(=O)O)sc1C(=O)OC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCc1cccc2[nH]ncc12.On1nnc2ccccc21>>CCc1cc(C(=O)NCc2cccc3[nH]ncc23)sc1C(=O)OC",
        "output": "950"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CC(O)(CC1=CC(=O)OC(C)(C)O1)C1CCCC1.CC(C)NC(C)C.CC(C)c1ccc(Br)cc1F.CCOC(C)=O.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>CC(C)c1ccc(C#CC(O)(CC2=CC(=O)OC(C)(C)O2)C2CCCC2)cc1F",
        "output": "659"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cn1oc(=O)nc1/C(=N\\OCn1ccc([N+](=O)[O-])n1)c1ccccc1.[Pt]>>Cn1oc(=O)nc1/C(=N\\OCn1ccc(N)n1)c1ccccc1",
        "output": "684"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CN(C2COC2)CCN1.CC#N.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[K+].[K+]>>O=[N+]([O-])c1ccc(N2CCN(C3COC3)CC2)cc1",
        "output": "26"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc2oc(-c3ccc(C=Cc4cccc(C(=O)O)c4)cc3)cc2c1.[Na+].[O-]c1ccccc1>>COc1ccc2oc(-c3ccc(C=Cc4cccc(C(=O)Oc5ccccc5)c4)cc3)cc2c1",
        "output": "355"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.O=C1CN(c2cc3c(cc2OCc2ccccc2)CC(O)CC3)S(=O)(=O)N1COCc1ccccc1>>O=C1CCc2cc(N3CC(=O)N(COCc4ccccc4)S3(=O)=O)c(OCc3ccccc3)cc2C1",
        "output": "87"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.O=C(CSCCCO)NC/C=C\\COc1cc(CN2CCCCC2)ccn1>>CC(=O)OCCCSCC(=O)NC/C=C\\COc1cc(CN2CCCCC2)ccn1",
        "output": "254"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.COc1ccc(Cl)cc1-c1ccc2nc(N)nc(N)c2c1Cl.ClCCl.[NH4+].[OH-]>>Nc1nc(N)c2c(Cl)c(-c3cc(Cl)ccc3O)ccc2n1",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.O.O=Cc1cccc([N+](=O)[O-])c1.OCCO.c1ccccc1>>O=[N+]([O-])c1cccc(C2OCCO2)c1",
        "output": "117"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.COc1ccc(C=O)c(Cl)c1O.c1ccncc1>>COc1ccc(C=O)c(Cl)c1OC(C)=O",
        "output": "46"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[O-].CCOC(=O)CCCCBr.CN(C)C=O.Cc1cc(C=O)cc(C)c1O.[K+]>>CCOC(=O)CCCCOc1c(C)cc(C=O)cc1C",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C(=O)c1nn(C)cc1[N+](=O)[O-].CO.[Pd]>>CN(C)C(=O)c1nn(C)cc1N",
        "output": "628"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCOc1nc(C(F)(F)F)ccc1CNC(=O)C(C)c1ccc(CN)c(OC)c1.CS(=O)(=O)Cl.ClCCl.c1ccncc1>>CCCCOc1nc(C(F)(F)F)ccc1CNC(=O)C(C)c1ccc(CNS(C)(=O)=O)c(OC)c1",
        "output": "742"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.CCN(CC)CC.CSc1nccc(-c2n[nH]c3nc(Cl)ncc23)n1.NCCN1CCCC1>>CSc1nccc(-c2n[nH]c3nc(NCCN4CCCC4)ncc23)n1",
        "output": "544"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.NC(=O)C1CCc2cc(S(=O)(=O)Cl)ccc2O1.Nc1ccc(-n2nnn(CCCC3CCCC3)c2=O)cc1.c1ccncc1>>NC(=O)C1CCc2cc(S(=O)(=O)Nc3ccc(-n4nnn(CCCC5CCCC5)c4=O)cc3)ccc2O1",
        "output": "68"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1cc(C(F)(F)F)cnc1NC1CC(F)(F)C1.O.[Li+].[OH-]>>O=C(O)c1cc(C(F)(F)F)cnc1NC1CC(F)(F)C1",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC[C@H]1CCN[C@@H]1C(C(=O)OC(C)(C)C)N1CCC[C@H]1C(=O)OC.CO.Cl.[Na+].[OH-]>>CC[C@H]1CCN[C@@H]1C(C(=O)OC(C)(C)C)N1CCC[C@H]1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)Cc1ccc(Nc2nc(-c3cccc(Cl)c3)nc3c2CCCC3)cc1.O.[Li+].[OH-]>>O=C(O)Cc1ccc(Nc2nc(-c3cccc(Cl)c3)nc3c2CCCC3)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(CN)C1.CC(Cl)Cl.CCN(C(C)C)C(C)C.CCOC(C)=O.O.O=C(O)COc1ncc(Br)cn1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCC(CNC(=O)COc2ncc(Br)cn2)C1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)C=C1CCCCC1.[Na+].[OH-]>>O=C(O)C=C1CCCCC1",
        "output": "122"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCc1c(C)nc(-c2ccc(Cl)s2)[nH]c1=O.O=P(Cl)(Cl)Cl>>CCc1c(C)nc(-c2ccc(Cl)s2)nc1Cl",
        "output": "14"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)C(=O)Cl.COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCN)C[C@H]1OC.ClC(Cl)Cl>>COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCNC(=O)N(C)C)C[C@H]1OC",
        "output": "454"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)C1.CCN(CC)CC.ClCCl.O=C(Cl)CCl>>CC(C)(C)OC(=O)N1CCC(NC(=O)CCl)C1",
        "output": "45"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccnc(N2CCN(CCN)CC2)c1.O=C(O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(Br)cc2)cc1>>Cc1ccnc(N2CCN(CCNC(=O)c3ccc(S(=O)(=O)Nc4ccccc4Oc4ccc(Br)cc4)cc3)CC2)c1",
        "output": "835"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(C)(O)C1CCCNC1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cl.F[B-](F)(F)F.O=C(O)c1cnoc1-c1ccc(C(F)(F)F)cc1.c1ccncc1>>CC(C)(O)C1CCCN(C(=O)c2cnoc2-c2ccc(C(F)(F)F)cc2)C1",
        "output": "975"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.N[C@@H](CCCCO)C(=O)O.O=S(Cl)Cl>>COC(=O)[C@@H](N)CCCCO",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.COC(=O)c1ccc(OCC2CC(F)(F)CN2)cc1.COc1cc(CC(=O)O)ccc1NC(=O)Nc1ccccc1C.Cl.On1nnc2ccccc21>>COC(=O)c1ccc(OCC2CC(F)(F)CN2C(=O)Cc2ccc(NC(=O)Nc3ccccc3C)c(OC)c2)cc1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[Si](C)(C)OCCCN(C1(C(=O)OCc2ccccc2)CCCC1)S(=O)(=O)c1ccc(-c2ccc(F)cc2)cc1.CCOCC.ClCCl.FB(F)F>>O=C(OCc1ccccc1)C1(N(CCCO)S(=O)(=O)c2ccc(-c3ccc(F)cc3)cc2)CCCC1",
        "output": "708"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.CI.O=C([O-])[O-].Oc1cccc(F)c1F.[K+].[K+]>>COc1cccc(F)c1F",
        "output": "62"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(N)C#N.O=C(O)c1cc(OCC2CC2)c(Cl)cn1>>CC(C)(C#N)NC(=O)c1cc(OCC2CC2)c(Cl)cn1",
        "output": "137"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cnc(Nc2ccc(C)nc2)c(C)c1.CO.[Na+].[OH-]>>Cc1ccc(Nc2ncc(C(=O)O)cc2C)cn1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCN(CCCN)CC2)c1.CN(C)C=O.ClC(Cl)Cl.O=C(O)C1(c2ccc(F)cc2)CCCC1>>CC(C)C(=O)Nc1cccc(C2CCN(CCCNC(=O)C3(c4ccc(F)cc4)CCCC3)CC2)c1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)Cl.OCCc1ccc(I)cc1>>CS(=O)(=O)OCCc1ccc(I)cc1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccccc1.CN(C)C=O.O.O=C(O)c1cc(OCc2ccccc2)c(F)c(F)c1Nc1ccccc1Cl.O=C([O-])O.[K+]>>O=C(OCc1ccccc1)c1cc(OCc2ccccc2)c(F)c(F)c1Nc1ccccc1Cl",
        "output": "403"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(Cc1cc2nc(-c3cccc(O)c3)nc(N3CCOCC3)c2s1)C(=O)OC(C)(C)C.Cl>>CNCc1cc2nc(-c3cccc(O)c3)nc(N3CCOCC3)c2s1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COc1ccc2cccc(COC(C)=O)c2c1.O.[Na+].[OH-]>>COc1ccc2cccc(CO)c2c1",
        "output": "497"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CS(=O)(=O)Cl.ClCCl.O=S(=O)(c1ccccc1)n1cc(-c2ccc3nc(CN4CCNCC4)[nH]c3c2)c2ccc(F)cc21>>CS(=O)(=O)N1CCN(Cc2nc3ccc(-c4cn(S(=O)(=O)c5ccccc5)c5cc(F)ccc45)cc3[nH]2)CC1",
        "output": "584"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(C(=O)O)c1ccc(CC(C)C)cc1.O=S(Cl)Cl>>CCC(C(=O)Cl)c1ccc(CC(C)C)cc1",
        "output": "53"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCc1ccccc1.CC(C)=O.N#CCc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>N#CCc1ccc(OCc2ccccc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)OB(c2cnn(C3CCNCC3)c2)OC1(C)C.CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.Cl.ClCCl>>CC1(C)OB(c2cnn(C3CCN(S(C)(=O)=O)CC3)c2)OC1(C)C",
        "output": "584"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCO.CCN.Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc2cnc(Cl)cc2n(C)c1=O>>CCNc1cc2c(cn1)cc(-c1cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc1C)c(=O)n2C",
        "output": "110"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "NC(c1ccc(Cl)cc1)c1ccc(Cl)cc1.O=C(O)CNC(=O)CCc1ccccc1>>O=C(CCc1ccccc1)NCC(=O)NC(c1ccc(Cl)cc1)c1ccc(Cl)cc1",
        "output": "769"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1cc2nc(Nc3nc4ccc(OC(F)(F)F)cc4s3)n(C)c2cc1F.[Li+].[OH-]>>Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)O)c(F)cc21",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.COc1ccccc1-c1nc2c(c(=O)n1CCc1ccccc1)CCCCCC2.ClCCl.O=C([O-])O.[Na+]>>O=c1c2c(nc(-c3ccccc3O)n1CCc1ccccc1)CCCCCC2",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CI.Cc1nc(C#Cc2ccnc(Cl)c2)cn1-c1cc[nH]c(=O)c1>>Cc1nc(C#Cc2ccnc(Cl)c2)cn1-c1ccn(C)c(=O)c1",
        "output": "191"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)CNc1nc(C#N)nc2ccc(O)cc12.CCCN1CCN(CCCCl)CC1.CN(C)C=O.O.O=C([O-])[O-].[Cs+].[Cs+]>>CCCN1CCN(CCCOc2ccc3nc(C#N)nc(NCC(C)(C)C)c3c2)CC1",
        "output": "74"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)[C@H](C=C(Cl)Cl)[C@@H]1C(=O)O.CCCCCC.CCOC(C)=O.Cc1ccccc1.O=C(Cl)C(=O)Cl.OCc1cccc(-c2ccc(Br)o2)c1.c1ccncc1>>CC1(C)[C@H](C=C(Cl)Cl)[C@@H]1C(=O)OCc1cccc(-c2ccc(Br)o2)c1",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(Cc2cccc(C(=O)NC(C)(C)C(F)(F)F)c2)CC1.ClCCl.O=C(O)C(F)(F)F>>CC(C)(NC(=O)c1cccc(CN2CCNCC2)c1)C(F)(F)F",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CCc1ccc(O)c2c1CCCC2.Cc1nc(-c2ccc(C(F)(F)F)cc2)ccc1CCO>>CCOC(=O)CCc1ccc(OCCc2ccc(-c3ccc(C(F)(F)F)cc3)nc2C)c2c1CCCC2",
        "output": "478"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCc1cc(NC(=O)Oc2ccccc2)cc(-c2nnnn2C)c1.CN(C)C=O.CN(Cc1ccccc1)[C@@H]1CCN(CCc2ccc(F)cc2)C[C@H]1CN>>CCc1cc(NC(=O)NC[C@@H]2CN(CCc3ccc(F)cc3)CC[C@H]2N(C)Cc2ccccc2)cc(-c2nnnn2C)c1",
        "output": "488"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.Fc1cccc2c1NCC2.O=C1CCC(=O)N1Br>>Fc1cc(Br)cc2c1NCC2",
        "output": "4"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.O.O=C([O-])[O-].O=Cc1ccc([N+](=O)[O-])c(O)c1.[K+].[K+]>>O=Cc1ccc([N+](=O)[O-])c(OCc2ccccc2)c1",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CC1CC1)C(=O)O.CI.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>COC(=O)[C@H](CC1CC1)NC(=O)OC(C)(C)C",
        "output": "415"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCOc1c(N)cc(Br)cc1C1CC1.ClCCl.O.O=C=Nc1ccc(C2CC2)cc1>>CCCOc1c(NC(=O)Nc2ccc(C3CC3)cc2)cc(Br)cc1C1CC1",
        "output": "473"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)CCc1ccc(OCC(C)c2nc(-c3ccc(-c4ccccn4)cc3)oc2C)cc1C.Cl.[Na+].[OH-]>>Cc1cc(OCC(C)c2nc(-c3ccc(-c4ccccn4)cc3)oc2C)ccc1CCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCC2=NCCCN2CC1.CC(C)(C)OC(=O)N[C@H]1CNC[C@@H]1N1CCCCC1=O.CS(C)=O.Clc1ncc(Br)cn1>>CC(C)(C)OC(=O)N[C@H]1CN(c2ncc(Br)cn2)C[C@@H]1N1CCCCC1=O",
        "output": "36"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1nc(I)ccc1[N+](=O)[O-].[Cl-].[Fe].[NH4+]>>Nc1ccc(I)nc1N",
        "output": "269"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.COC(=O)c1ccc(-c2ccc(O)cc2)cc1.O.O=[N+]([O-])O>>COC(=O)c1ccc(-c2ccc(O)c([N+](=O)[O-])c2)cc1",
        "output": "21"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)C(C)(C)[SiH2]Oc1cccc(-c2nc(N3CCOCC3)c3sc(C=O)cc3n2)c1.CN1CCNCC1.ClCCCl.[Na+]>>CN1CCN(Cc2cc3nc(-c4cccc(O[SiH2]C(C)(C)C(C)(C)C)c4)nc(N4CCOCC4)c3s2)CC1",
        "output": "792"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.Cl.ClCCl.O=C(OCC1c2ccccc2-c2ccccc21)N1CC[C@H]2NC[C@H](O)[C@H]21.O=S(=O)(Cl)c1ccccc1>>O=C(OCC1c2ccccc2-c2ccccc21)N1CC[C@@H]2[C@H]1[C@@H](O)CN2S(=O)(=O)c1ccccc1",
        "output": "99"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COCCOc1ncc(Br)cc1C(=O)O.O=S(=O)(O)O>>COCCOc1ncc(Br)cc1C(=O)OC",
        "output": "521"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1sc2ncnc(Nc3cccnc3O[C@@H]3CCCOC3)c2c1C.Cl.O.[Na+].[OH-]>>Cc1c(C(=O)O)sc2ncnc(Nc3cccnc3O[C@@H]3CCCOC3)c12",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCN(C2CCNCC2)C1.O=C1c2c(-c3ccc(Cl)cc3)cc(Cl)nc2OCCCN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>O=C1c2c(-c3ccc(Cl)cc3)cc(N3CCC(N4CCCC4)CC3)nc2OCCCN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "220"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.Cc1nc2ccccc2n1C1C[C@H]2CC[C@@H](C1)N2CCC1(c2cccc(F)c2)CCN(C(=O)[C@@H](N)C(C)C)CC1.O=C(Cl)C(Cl)Cl>>Cc1nc2ccccc2n1C1C[C@H]2CC[C@@H](C1)N2CCC1(c2cccc(F)c2)CCN(C(=O)[C@@H](NC(=O)C(Cl)Cl)C(C)C)CC1",
        "output": "159"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CNC(=O)Nc1ccc(-c2nc(-c3ccc(N)cc3)nc(N3CC4CCC(C3)O4)n2)cc1.NC(=O)c1ccc(NC(=O)Oc2ccccc2)cc1>>CNC(=O)Nc1ccc(-c2nc(-c3ccc(NC(=O)Nc4ccc(C(N)=O)cc4)cc3)nc(N3CC4CCC(C3)O4)n2)cc1",
        "output": "948"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COC(=O)CNC(=O)c1cc(OC(F)(F)F)ccc1NC(=O)OC(C)(C)C.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>CC(C)(C)OC(=O)Nc1ccc(OC(F)(F)F)cc1C(=O)NCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)c1cn(Cc2ccc(Cn3ccccc3=O)cc2)nn1.O.[Li+].[OH-]>>O=C(O)c1cn(Cc2ccc(Cn3ccccc3=O)cc2)nn1",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CCO.CCOC(C)=O.CCOCCOCC.Cc1cc(Cl)c(Cl)cc1[N+](=O)[O-]>>Cc1cc(N2CCOCC2)c(Cl)cc1[N+](=O)[O-]",
        "output": "105"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)NCCCCCCCCNc1nc(Nc2ccc(C(=O)NCCCCl)cc2)nc(OCC(F)(F)F)n1.ClCCl.O=C(O)C(F)(F)F>>NCCCCCCCCNc1nc(Nc2ccc(C(=O)NCCCCl)cc2)nc(OCC(F)(F)F)n1",
        "output": "538"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O=c1ccn2c3c(cc(O)cc13)Sc1ccc(Br)cc1-2.OCCCBr>>O=c1ccn2c3c(cc(OCCCO)cc13)Sc1ccc(Br)cc1-2",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cnc(C)c(N2CC3CNCC3C2)n1.O=C(O)c1cc(F)ccc1-c1ncccn1>>Cc1cnc(C)c(N2CC3CN(C(=O)c4cc(F)ccc4-c4ncccn4)CC3C2)n1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COCC(=O)Cl.COc1nc(N)c(C#N)c(C2CCCCO2)c1C#N.[H-].[Na+]>>COCC(=O)Nc1nc(OC)c(C#N)c(C2CCCCO2)c1C#N",
        "output": "332"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)C1.CN(C)C=O.Clc1ncc(Cl)c(Cl)n1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCC(Oc2nc(Cl)ncc2Cl)C1",
        "output": "461"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCNCC.CCOC(C)=O.O=C(Cl)Cc1ccc([N+](=O)[O-])cc1Cl>>CCN(CC)C(=O)Cc1ccc([N+](=O)[O-])cc1Cl",
        "output": "125"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CO.O=[N+]([O-])c1ccc(OCCO)cc1.[H][H].[Pd]>>Nc1ccc(OCCO)cc1",
        "output": "202"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1cc(Br)ccc1OC(F)(F)F.CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.CN1CCNCC1.C[Si](C)(C)[N-][Si](C)(C)C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Li+].[Pd].[Pd]>>CC(=O)Nc1cc(N2CCN(C)CC2)ccc1OC(F)(F)F",
        "output": "294"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1nc(CC)c(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1nc(CC)c(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)O.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc2cc(C(=O)O)ccc2c1.O.[Na+].[OH-]>>CC(C)(C)OC(=O)Nc1ccc2cc(C(=O)O)ccc2c1",
        "output": "735"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CCN(CC)CC.COc1ccc(Br)cc1S(=O)(=O)Cl.ClCCl>>COc1ccc(Br)cc1S(=O)(=O)NC1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "43"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=C(C)C(=O)O.Cc1ccc(S(=O)(=O)O)cc1.ClC(Cl)Cl.O.O=C(O)c1ccc(OCCO)cc1.Oc1ccc(O)cc1>>C=C(C)C(=O)OCCOc1ccc(C(=O)O)cc1",
        "output": "174"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1.CCO.[H][H].[Pd]>>CC(C)(C)OC(=O)N1CCN(c2ccc(N)cc2)CC1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.Cn1c(CCl)nc2cc(C#N)ccc21.Fc1ccccc1C1CCNCC1.O=C([O-])[O-].[I-].[Na+].[Na+]>>Cn1c(CN2CCC(c3ccccc3F)CC2)nc2cc(C#N)ccc21",
        "output": "257"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)N(C)C.CCOC(=O)CBr.COc1cccc(O)c1.[H-].[Na+]>>CCOC(=O)COc1cccc(OC)c1",
        "output": "123"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.Cl[Pd]Cl.NS(=O)(=O)c1ccc(Br)cc1.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc(S(N)(=O)=O)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN1C(=O)CCc2cc(-c3cncc(O[C@H]4CCNC4)c3)ccc21.Cl.Cn1cc(C(=O)O)cn1.O=C([O-])O.[Na+]>>CN1C(=O)CCc2cc(-c3cncc(O[C@H]4CCN(C(=O)c5cnn(C)c5)C4)c3)ccc21",
        "output": "733"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC2=NCCCN2CC1.CI.CN(C)C=O.O.O=C(O)c1ccc(Br)cc1[N+](=O)[O-]>>COC(=O)c1ccc(Br)cc1[N+](=O)[O-]",
        "output": "415"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(C(=O)C#Cc2cc(-c3cccs3)c(OC)cc2OC)cc1.O.[Na+].[OH-]>>COc1cc(OC)c(-c2cccs2)cc1C#CC(=O)c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)C(C)(C)Cc1cc2c(c(OC)c1)OC(C)(C)C2.CO.Cl.[Na+].[OH-]>>COc1cc(CC(C)(C)C(=O)O)cc2c1OC(C)(C)C2",
        "output": "281"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCCCOc1ccccc1.CN(C)C=O.COc1ccc(S(=O)(=O)N2CCc3ccccc32)cc1O.O=C([O-])[O-].[Cs+].[Cs+]>>COc1ccc(S(=O)(=O)N2CCc3ccccc32)cc1OCCCOc1ccccc1",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrC(Br)(Br)Br.CCCCCCC(=O)N(CCCCCO)C(C)C.ClCCl.O>>CCCCCCC(=O)N(CCCCCBr)C(C)C",
        "output": "378"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1C[C@@H](O)[C@H](C#N)C1.CI>>CO[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1C#N",
        "output": "140"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.COC(C)(C)C.COCCCS(=O)(=O)c1ccc(-c2ccc(CCO)cc2)cc1.CS(=O)(=O)Cl>>COCCCS(=O)(=O)c1ccc(-c2ccc(CCOS(C)(=O)=O)cc2)cc1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)n1ncc2cc(Nc3nc(-c4cccc(NC(=O)NCc5ccccc5)c4)nc4ccccc34)ccc21.ClCCl.O=C(O)C(F)(F)F>>O=C(NCc1ccccc1)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3ccccc3n2)c1",
        "output": "896"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCNCC(O)(CNc1cccc2c1cnn2-c1ccccc1)C(F)(F)F.O=C(O)c1cccs1>>CCCN(CC(O)(CNc1cccc2c1cnn2-c1ccccc1)C(F)(F)F)C(=O)c1cccs1",
        "output": "857"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(C(C)C)C(C)C.ClCCl.O=[N+]([O-])c1ccc(Br)cc1NCCCO>>CC(C)(C)[Si](C)(C)OCCCNc1cc(Br)ccc1[N+](=O)[O-]",
        "output": "193"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CCOCC.CN1CCN(c2ccc(C(=O)OC(C)(C)C)c(N(C(=O)C(F)(F)F)C3CCC(F)(F)CC3)c2)CC1.ClCCl.O=C(O)C(F)(F)F>>CN1CCN(c2ccc(C(=O)O)c(N(C(=O)C(F)(F)F)C3CCC(F)(F)CC3)c2)CC1",
        "output": "752"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=O.CO.NC(=O)c1cccc2[nH]c(C34CCCC(CN3)C4)nc12.[BH3-]C#N.[Na+]>>CN1CC2CCCC1(c1nc3c(C(N)=O)cccc3[nH]1)C2",
        "output": "217"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.NC(=O)c1ccc2[nH]c(-c3ccc(C4(c5ccccc5)OCCO4)cc3)nc2c1.O=C(O)c1ccc2[nH]c(-c3ccc(C4(c5ccc(Cl)cc5)OCCO4)cc3)nc2c1.O=C([O-])O.O=C(n1ccnc1)n1ccnc1.[Cl-].[NH4+].[NH4+]>>NC(=O)c1ccc2[nH]c(-c3ccc(C4(c5ccc(Cl)cc5)OCCO4)cc3)nc2c1",
        "output": "358"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.Cl.ClCCl.NCCc1ccc([N+](=O)[O-])cc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(NCCc1ccc([N+](=O)[O-])cc1)C(F)(F)F",
        "output": "316"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(I)c1.O.O=C([O-])[O-].OB(O)c1ccccc1.[Na+].[Na+]>>CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(-c2ccccc2)c1",
        "output": "855"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCO.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Cn1cc(C(N)=O)c(Nc2ccc(I)cc2F)cc1=O.[Cu]I>>Cn1cc(C(N)=O)c(Nc2ccc(C#CCO)cc2F)cc1=O",
        "output": "664"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.CO.COc1ccc2c(c1)CC(c1cc(Cl)cc(Cl)c1)(C(F)(F)F)S2.ClCCl>>Oc1ccc2c(c1)CC(c1cc(Cl)cc(Cl)c1)(C(F)(F)F)S2",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cccc(C(=N)NN)n1.O=Cc1cc(F)ccc1O>>Cc1cccc(-c2n[nH]c(-c3cc(F)ccc3O)n2)n1",
        "output": "994"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1CCNC(=O)c2cc3cc(F)cc(Br)c3n21.OB(O)c1ccc(F)cc1>>CC1CCNC(=O)c2cc3cc(F)cc(-c4ccc(F)cc4)c3n21",
        "output": "833"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.FC(F)(F)Oc1ccc(OC2CCN(c3ccc(OCc4ccccc4)cc3)CC2)cc1.[H][H].[Pd]>>Oc1ccc(N2CCC(Oc3ccc(OC(F)(F)F)cc3)CC2)cc1",
        "output": "698"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC[C@H](C)O.Clc1ncc(Cl)c(Cl)n1.[H-].[Na+]>>COC[C@H](C)Oc1nc(Cl)ncc1Cl",
        "output": "461"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCC.CCOC(C)=O.CN(C)C=O.N#Cc1cc(Cl)c(C2CC2)cn1.OC1CCOCC1.[H-].[Na+]>>N#Cc1cc(OC2CCOCC2)c(C2CC2)cn1",
        "output": "651"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COc1cnccc1-c1ccc([N+](=O)[O-])c(OC(C)C)c1.O=C[O-].[NH4+].[Pd]>>COc1cnccc1-c1ccc(N)c(OC(C)C)c1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOc1cc(Br)ccc1-c1nc2c(c(C3CCCCC3)nn2C)c(=O)[nH]1.COCCN>>CCOc1cc(NCCOC)ccc1-c1nc2c(c(C3CCCCC3)nn2C)c(=O)[nH]1",
        "output": "519"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(O)Cn1c(CNC(=O)CC2CC2)nc2cnc3cccnc3c21.Cc1ccc(S(=O)(=O)Cl)cc1.O=C(OO)c1cccc(Cl)c1.[NH4+].[OH-]>>CC(C)(O)Cn1c(CNC(=O)CC2CC2)nc2c(N)nc3cccnc3c21",
        "output": "959"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.[N-]=[N+]=NC1CCOc2ncccc21.[Pd]>>NC1CCOc2ncccc21",
        "output": "89"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2c(-c3ccccc3)cnc3[nH]ccc23)CC1.Cl.Cl.ClCCl.Nc1c(F)c(N)c(F)c(F)c1F.O=C(O)C(F)(F)F>>N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2c(-c3ccccc3)cnc3[nH]ccc23)CC1",
        "output": "431"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cc1cnn(C2CCCCO2)c1-c1cn(C(C)C)c2cc(Nc3ccnc(-c4cnn(S(=O)(=O)C5CC5)c4)n3)ncc12.Cl>>Cc1cn[nH]c1-c1cn(C(C)C)c2cc(Nc3ccnc(-c4cnn(S(=O)(=O)C5CC5)c4)n3)ncc12",
        "output": "689"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCC=O.Cc1c(N)cccc1-c1ccc(C(F)(F)F)cc1.ClCCl.[Na+]>>CCCCNc1cccc(-c2ccc(C(F)(F)F)cc2)c1C",
        "output": "336"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.C[C@@]1(CO)CCCN1C(=O)OCc1ccccc1.ClC(Cl)Cl.O=S([O-])([O-])=S.[Na+].[Na+].c1ccncc1>>C[C@@]1(C=O)CCCN1C(=O)OCc1ccccc1",
        "output": "610"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1cc(=O)c2c(OCC(O)COc3ccc(Cl)cc3)cccc2o1.[Na+].[OH-]>>O=C(O)c1cc(=O)c2c(OCC(O)COc3ccc(Cl)cc3)cccc2o1",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[O-].CCC1(CC)c2ccccc2-c2ccc(Br)cc21.CCOCC.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(Nc2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CCC1(CC)c2ccccc2-c2ccc(N(c3ccccc3)c3ccccc3)cc21",
        "output": "894"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NCc1ccccc1Cl.O=C(O)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1>>O=C(NCc1ccccc1Cl)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1",
        "output": "753"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.O=C1NC2(CCN(Cc3ccccc3)CC2)Nc2ccccc21.[C].[Pd]>>O=C1NC2(CCNCC2)Nc2ccccc21",
        "output": "84"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC(N2CCC(F)(F)CC2)C1.ClCCl.O=C(O)C(F)(F)F>>FC1(F)CCN(C2CNC2)CC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)c1cc(OCc2ccccc2)c2nc(C)n(C)c2c1.CC(=O)O.CCO.[Pd]>>CC(=O)N(C)c1cc(O)c2nc(C)n(C)c2c1",
        "output": "264"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C1CCOC1.CNC.N#Cc1cc(Cl)ccc1NC(=O)Oc1ccccc1.O=C([O-])O.[Na+]>>CN(C)C(=O)Nc1ccc(Cl)cc1C#N",
        "output": "525"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC1C=C(C)C(F)C(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(N=[N+]=[N-])C(O)C3)C(C)CCC1=O)C(C)CC2OC.CI.O=[Ag]>>CCC1C=C(C)C(F)C(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(N=[N+]=[N-])C(OC)C3)C(C)CCC1=O)C(C)CC2OC",
        "output": "140"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)OB(c2cccc(N)c2Cl)OC1(C)C.COc1cc(Br)cc([N+](=O)[O-])c1C>>COc1cc(Br)cc(N)c1C",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.COc1c(N)c(F)cc(Cl)c1[N+](=O)[O-].Cc1ccccc1.S=C(Cl)Cl>>COc1c(N=C=S)c(F)cc(Cl)c1[N+](=O)[O-]",
        "output": "114"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOCC.COc1ccc(C(C)C)cc1-c1nc2ccccc2cc1C=O.[BH4-].[Cl-].[NH4+].[Na+]>>COc1ccc(C(C)C)cc1-c1nc2ccccc2cc1CO",
        "output": "476"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.COc1ccc(C2(C)CSc3cc(OC)ccc3C2CCCCCCO)cc1.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl>>COc1ccc(C2(C)CSc3cc(OC)ccc3C2CCCCCC=O)cc1",
        "output": "142"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CCc1cc([N+](=O)[O-])c(OC)cc1N1CCC(CCS(C)(=O)=O)CC1.[Pt]>>CCc1cc(N)c(OC)cc1N1CCC(CCS(C)(=O)=O)CC1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCn1cc(C(=O)OC)c2ccccc21.CO.[Na+].[OH-]>>CCn1cc(C(=O)O)c2ccccc21",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "N.NCCCOc1cccc(CN2CCCCC2)c1.O.O=C(O)CO>>O=C(CO)NCCCOc1cccc(CN2CCCCC2)c1",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)NC(=O)c1ccc2n1CCNC2C.O=C(O)c1cc2ncc(Cl)cn2n1>>CC(C)NC(=O)c1ccc2n1CCN(C(=O)c1cc3ncc(Cl)cn3n1)C2C",
        "output": "663"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCCC1=O.Cn1c(=O)n(CC(C)(C)C)c2ccc(C3=CCC(N)CC3)nc21.Cn1ccnc1C(=O)O.F[P-](F)(F)(F)(F)F>>Cn1ccnc1C(=O)NC1CC=C(c2ccc3c(n2)n(C)c(=O)n3CC(C)(C)C)CC1",
        "output": "951"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.CN1CCN(CCO)CC1.Cc1ccccc1.Oc1c(Br)ccc(Cl)c1Cl.Oc1ccc(Br)c(Cl)c1Cl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN1CCN(CCOc2ccc(Br)c(Cl)c2Cl)CC1",
        "output": "550"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C[C@@H](NC(=O)OCc1ccccc1)C(=O)O.NC12CC3CC(CC(C3)C1)C2.On1nnc2ccccc21>>C[C@@H](NC(=O)OCc1ccccc1)C(=O)NC12CC3CC(CC(C3)C1)C2",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCN(CC(=O)O)CC1.NCc1ccccn1>>CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCN(CC(=O)NCc2ccccn2)CC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CI.Cn1c(C(F)(F)F)cc(=O)n(-c2cc(O)c(Br)cc2F)c1=O.O=C([O-])[O-].[K+].[K+]>>COc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Br",
        "output": "62"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)Cl.Oc1ccc(F)cc1Cl.c1ccncc1>>CS(=O)(=O)Oc1ccc(F)cc1Cl",
        "output": "149"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cc1ncc(C(=O)O)c(C)c1Oc1ccnc(Cl)c1.O=C([O-])O.O=S(=O)(O)O.[Na+].c1ccccc1>>CCOC(=O)c1cnc(C)c(Oc2ccnc(Cl)c2)c1C",
        "output": "521"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCc1cccc(CC)c1Br.COB(OC)OC.Cl.[Li]CCCC>>CCc1cccc(CC)c1B(O)O",
        "output": "789"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(OCC)[C@H](C)N(Cc1cccc2ccccc12)C(=O)[C@@H](N)CCCCNC(=O)OC(C)(C)C.O=C(O)CONC(=O)NCc1cccc2ccccc12>>CCOC(OCC)[C@H](C)N(Cc1cccc2ccccc12)C(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)CONC(=O)NCc1cccc2ccccc12",
        "output": "133"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)SCC(C)C(=O)N(CC(=O)OC(C)(C)C)C1CCCC1.CO>>CC(CS)C(=O)N(CC(=O)OC(C)(C)C)C1CCCC1",
        "output": "90"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N[C@H]1C[C@@H](N2CC3=C(C2)N(S(=O)(=O)C2CCCC2)NC3)CO[C@@H]1c1cc(F)ccc1F.ClCCl.O=C(O)C(F)(F)F>>N[C@H]1C[C@@H](N2CC3=C(C2)N(S(=O)(=O)C2CCCC2)NC3)CO[C@@H]1c1cc(F)ccc1F",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CCCN[C@H](C)Cc1cccc(NC(=O)c2ccc(OC)cc2)c1.CCOCC.O=CC1CCN(C(=O)N2CCOCC2)CC1.[Na+].[Na+].[OH-]>>CCCN(CC1CCN(C(=O)N2CCOCC2)CC1)[C@H](C)Cc1cccc(NC(=O)c2ccc(OC)cc2)c1",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O=C(O)Cc1ccc(O)cc1>>COC(=O)Cc1ccc(O)cc1",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O.CCN(CC)CC.CCN=C=O.O=Cc1ccccc1O>>CCNC(=O)Oc1c(C(C)(C)C)cc(C=O)cc1C(C)(C)C",
        "output": "104"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(C)C=O.COc1ccc2ncc(=O)n(CCC=O)c2n1.ClCCl.NC1CC(=O)N(c2ccc3c(c2)NC(=O)CO3)C1.O=C([O-])O.O=S(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+]>>COc1ccc2ncc(=O)n(CCCNC3CC(=O)N(c4ccc5c(c4)NC(=O)CO5)C3)c2n1",
        "output": "426"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc2nccc(Cl)c2cc1OC.Cc1cc(Cn2cncc(-c3ccc(O)c(F)c3)c2=O)ccc1F>>COc1cc2nccc(Oc3ccc(-c4cncn(Cc5ccc(F)c(C)c5)c4=O)cc3F)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)C=O.Nc1c(Br)c(OCC2CCNCC2)nc2c(-c3cnc4ccccc4c3)cnn12.O=S(=O)(Cl)C1CC1>>Nc1c(Br)c(OCC2CCN(S(=O)(=O)C3CC3)CC2)nc2c(-c3cnc4ccccc4c3)cnn12",
        "output": "584"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.COc1ccc(-c2nn3c(NCCCCN)cccc3c2-c2ccnc(NC3CCCC3)n2)cc1.CS(=O)(=O)Cl.ClCCl.O=C([O-])O.[Na+]>>COc1ccc(-c2nn3c(NCCCCNS(C)(=O)=O)cccc3c2-c2ccnc(NC3CCCC3)n2)cc1",
        "output": "493"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(F)cc1B(O)O.Nc1c2c(nc3c(Br)c(F)ccc13)CN(C1CCC1)C2=O>>COc1ccc(F)cc1-c1c(F)ccc2c(N)c3c(nc12)CN(C1CCC1)C3=O",
        "output": "833"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CC1(O)CN2CCC1CC2.CCCCOc1ccc(I)cc1.CCN(CC)CC.CN(C)C=O.Cl[Pd]Cl.[Cu]I.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCCOc1ccc(C#CC2(O)CN3CCC2CC3)cc1",
        "output": "664"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC2=NCCCN2CC1.C1COCCO1.CC(=O)OCCCS(N)(=O)=O.CCC[C@H]1CCCN1Cc1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1.O.O=C(O)C(F)(F)F.O=C(n1ccnc1)n1ccnc1>>CCC[C@H]1CCCN1Cc1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)NS(=O)(=O)CCCOC(C)=O)cc1",
        "output": "580"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC[SiH](CC)CC.CCc1cc(F)c2ccc(C)cc2c1C=O.COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.O=C(O)C(F)(F)F>>CCc1cc(F)c2ccc(C)cc2c1CNC(=O)c1c(OC)cc(O)c2c1OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C",
        "output": "996"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CCBr.CC(C)=O.CCC(C)=O.CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3O)nc12.O=C([O-])[O-].[K+].[K+]>>C=CCOc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1",
        "output": "77"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCN.Clc1nc(N2CC3CCC(CC3)C2)nc(N2CC3CCC(CC3)C2)n1>>CCCCNc1nc(N2CC3CCC(CC3)C2)nc(N2CC3CCC(CC3)C2)n1",
        "output": "578"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.COc1ccc(C2(C)CSc3cc(OC)ccc3C2CCCCCCCCCO)cc1.CS(=O)(=O)Cl.ClCCl.O>>COc1ccc(C2(C)CSc3cc(OC)ccc3C2CCCCCCCCCOS(C)(=O)=O)cc1",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cl.N#Cc1ccc(CN)c(O)c1.O=C(O)c1cc(Cl)cc(OCc2cc(Cl)cc(Cl)c2)c1>>N#Cc1ccc(CNC(=O)c2cc(Cl)cc(OCc3cc(Cl)cc(Cl)c3)c2)c(O)c1",
        "output": "753"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)C[AlH]CC(C)C.CCOC(=O)Cc1ccc2c(c1)C1(CCN(C(=O)OC(C)(C)C)CC1)CN2c1ncnc2c1[C@H](C)CC2.O=C([O-])[C@H](O)[C@@H](O)C(=O)[O-].[K+].[Na+]>>C[C@@H]1CCc2ncnc(N3CC4(CCN(C(=O)OC(C)(C)C)CC4)c4cc(CCO)ccc43)c21",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COC(=O)C1(c2ccc(Br)cc2)CC(F)(F)C1.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.N#N.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[C-]#N.[C-]#N.[Pd].[Pd].[Zn+2]>>COC(=O)C1(c2ccc(C#N)cc2)CC(F)(F)C1",
        "output": "65"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)c1ccncc1.Cl.FC1(F)CNCC(COc2ccc(Cl)cc2)C1.O=C(O)c1cccc(-c2cn[nH]c2)c1>>O=C(c1cccc(-c2cn[nH]c2)c1)N1CC(COc2ccc(Cl)cc2)CC(F)(F)C1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(N)cc1-c1cncnc1.ClCCl.Clc1nccc2c(-n3cccc3)cccc12.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(Nc2nccc3c(-n4cccc4)cccc23)cc1-c1cncnc1",
        "output": "434"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.COc1cc(OC)c(F)c(N2Cc3cnc(-c4cn(C)nc4C)cc3N(C3CCNCC3)C2=O)c1F.ClCCl.c1ccncc1>>COc1cc(OC)c(F)c(N2Cc3cnc(-c4cn(C)nc4C)cc3N(C3CCN(C(C)=O)CC3)C2=O)c1F",
        "output": "125"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=C(C)C(=O)O.CC#N.CCN(CC)CC.CCOC(=O)Cl.Cl.Nc1ccc(C(=O)O)cc1>>C=C(C)C(=O)Nc1ccc(C(=O)O)cc1",
        "output": "170"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1CCCC(C(=O)O)C1.O=C(NCCC1CC1)c1ccc(N2CCNCC2)nn1>>CC1CCCC(C(=O)N2CCN(c3ccc(C(=O)NCCC4CC4)nn3)CC2)C1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NC1CCN(Cc2ccc(-c3cc4nccc(Oc5ccc(NC(=O)NC6CC6)cc5F)c4s3)nc2)CC1.O=C(O)C(F)(F)F>>NC1CCN(Cc2ccc(-c3cc4nccc(Oc5ccc(NC(=O)NC6CC6)cc5F)c4s3)nc2)CC1",
        "output": "538"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)CCN1C(=O)C(C(C)C)Oc2ccccc21.[Na+].[OH-]>>CC(C)C1Oc2ccccc2N(CCC(=O)O)C1=O",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CNC(=O)c1cc(Oc2ccc(CCC(=O)O)cc2)ccn1.ClCCl.F[B-](F)(F)F.Nc1ccccc1.O>>CNC(=O)c1cc(Oc2ccc(CCC(=O)Nc3ccccc3)cc2)ccn1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cn1c(Nc2nc3cc(F)c(F)cc3s2)nc2cc(C(=O)O)ccc21.F[P-](F)(F)(F)(F)F>>CNC(=O)c1ccc2c(c1)nc(Nc1nc3cc(F)c(F)cc3s1)n2C",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc2ccc(Br)c(C)c2n1.FC(F)(F)c1ccccc1.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br.[W]>>COc1ccc2ccc(Br)c(CBr)c2n1",
        "output": "625"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)CCc1cc(F)c(OCc2sc(Cl)cc2-c2ccc(CC)cc2)c(F)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCc1ccc(-c2cc(Cl)sc2COc2c(F)cc(CCCO)cc2F)cc1",
        "output": "225"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(S(=O)(=O)NCCCCCCN)cc1.Cl.Cl.O=C(Cl)C(=O)Cl.O=C(O)C=Cc1cccnc1>>Cc1ccc(S(=O)(=O)NCCCCCCNC(=O)C=Cc2cccnc2)cc1",
        "output": "549"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1nc(C#N)c2c(c1O)c(Cl)c(Cl)n2CCC(C)C.CO.C[O-].NCC(=O)O.[Na+]>>CC(C)CCn1c(Cl)c(Cl)c2c(O)c(C(=O)NCC(=O)O)nc(C#N)c21",
        "output": "977"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.CC(=O)O.CCOCC.O=C(N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)Nc1ccccc1)OCc1ccccc1>>N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)Nc1ccccc1",
        "output": "128"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.C1COCCOCCOCCOCCO1.CN(Cc1c[nH]c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C.COc1cccc(S(=O)(=O)Cl)c1.O.[H-].[Na+]>>COc1cccc(S(=O)(=O)n2cc(CN(C)C(=O)OC(C)(C)C)c(F)c2-c2cccnc2F)c1",
        "output": "648"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)NCc1nc2cc(Br)cnc2[nH]1.CCO.Cl>>NCc1nc2cc(Br)cnc2[nH]1",
        "output": "412"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(O)(CC(C)(C)c1cccc2c1OCO2)C(F)(F)F.CCOCC.O=C([O-])O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+]>>CC(C)(CC(O)(CO)C(F)(F)F)c1cccc2c1OCO2",
        "output": "225"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.O.O=C(NC1CCNCC1)C(F)(F)F.O=C([O-])[O-].O=C(c1ccc(OCCCCCBr)cc1)N1CCC(N2C(=O)CCc3ccccc32)CC1.[K+].[K+]>>O=C(c1ccc(OCCCCCN2CCC(NC(=O)C(F)(F)F)CC2)cc1)N1CCC(N2C(=O)CCc3ccccc32)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)Cc1nn(-c2ccccn2)c2[nH]c3ccccc3c(=O)c12.Cl.[Na+].[OH-]>>O=C(O)Cc1nn(-c2ccccn2)c2[nH]c3ccccc3c(=O)c12",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCO.OC1CC2CCC1NC2.[Pd]>>CC(C)(C)OC(=O)N1CC2CCC1C(O)C2",
        "output": "694"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CCN(CC)CC.COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CNCC(N)=O)c1.COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CO)c1.ClCCl.O>>COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2COC(C)=O)c1",
        "output": "126"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)C(N)CO.CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cc2cc(C(=O)Nc3cc(C(=O)O)ccc3C)c(=O)[nH]c2cc1OC.F[P-](F)(F)(F)(F)F.O.O=C([O-])O.[Na+]>>COc1cc2cc(C(=O)Nc3cc(C(=O)NC(CO)C(C)C)ccc3C)c(=O)[nH]c2cc1OC",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCn2c(nc3cc(Br)ccc32)C1.CN[C@@H]1CCCC[C@H]1NC.CO.ClCCl.O=C([O-])[O-].O=c1cc(OCc2ccccc2)cc[nH]1.[Cs+].[Cs+].[Cu]I.[NH4+].[OH-]>>CC(C)(C)OC(=O)N1CCn2c(nc3cc(-n4ccc(OCc5ccccc5)cc4=O)ccc32)C1",
        "output": "982"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COCC(=O)Cl.Cl.O=C(NC1CCNCC1)c1c[nH]c2c(-c3cc(F)ccc3OCC3CC3)ncnc12>>COCC(=O)N1CCC(NC(=O)c2c[nH]c3c(-c4cc(F)ccc4OCC4CC4)ncnc23)CC1",
        "output": "125"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)c1ccc(F)c(C=O)c1.CCOc1cc(C[C@@H]2CS(=O)(=O)C[C@H](N)[C@H]2O)cc(F)c1[N+](=O)[O-].Cl>>CCOc1cc(C[C@@H]2CS(=O)(=O)C[C@H](NCc3cc(C(C)(C)C)ccc3F)[C@H]2O)cc(F)c1[N+](=O)[O-]",
        "output": "468"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)[O-].CC(C)(C)OC(=O)c1ccc(-n2c(CCC(=O)O)ccc2-c2ccccc2)cc1.O=C(n1ccnc1)n1ccnc1.[NH4+]>>CC(C)(C)OC(=O)c1ccc(-n2c(CCC(N)=O)ccc2-c2ccccc2)cc1",
        "output": "313"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC[O-].Cc1[nH]nc(Nc2ncnc3cc(F)c(S(=O)(=O)C(C)(C)C)cc23)c1C.Cl.[Na+]>>CCOc1cc2ncnc(Nc3n[nH]c(C)c3C)c2cc1S(=O)(=O)C(C)(C)C",
        "output": "636"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CNC(=O)c1ccc(C=CC(=O)O)cc1.Cc1ccc2cccc(OCc3c(Cl)ccc(C(=O)N4CCNCC4)c3Cl)c2n1.Cl.Cl.O.On1nnc2ccccc21>>CNC(=O)c1ccc(C=CC(=O)N2CCN(C(=O)c3ccc(Cl)c(COc4cccc5ccc(C)nc45)c3Cl)CC2)cc1",
        "output": "517"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)c1ccncc1.ClCCl.Nc1ccc(F)c2cccnc12.O=S(=O)(Cl)c1ccccc1>>O=S(=O)(Nc1ccc(F)c2cccnc12)c1ccccc1",
        "output": "554"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.O.O=S(=O)(Cl)c1cc(F)c(Br)cc1F.[NH4+].[OH-]>>NS(=O)(=O)c1cc(F)c(Br)cc1F",
        "output": "245"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(C)(C)Oc1ccc(O)cc1OC.Cc1nc(-c2ccc(C(F)(F)F)cc2)ccc1CCl>>CCOC(=O)C(C)(C)Oc1ccc(OCc2ccc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1OC",
        "output": "678"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cc2c(nc1C)C(O)CCCC2.CI.O.[H-].[Na+]>>CCOC(=O)c1cc2c(nc1C)C(OC)CCCC2",
        "output": "140"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCc1cnc(N2CCNCC2)c(C)c1.Cc1cc(Br)ccc1C(=O)O>>CCc1cnc(N2CCN(C(=O)c3ccc(Br)cc3C)CC2)c(C)c1",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cc(C)c([N+](=O)[O-])c(=O)[nH]1.O=P(Cl)(Cl)Cl>>Cc1cc(C)c([N+](=O)[O-])c(Cl)n1",
        "output": "100"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CO.COc1ccc(-c2cc(C)cc(NC(=O)C3(c4ccc5c(c4)OCC5)CC3)n2)cn1.C[Si](C)(C)I>>Cc1cc(NC(=O)C2(c3ccc4c(c3)OCC4)CC2)nc(-c2ccc(=O)[nH]c2)c1",
        "output": "758"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)Cl.ClCCl.Nc1cccnc1C1CCC2(CC1)OCCO2.c1ccncc1>>CS(=O)(=O)Nc1cccnc1C1CCC2(CC1)OCCO2",
        "output": "812"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CC(C)ON=C(C(=O)O)c1csc(NC=O)n1.CCOC(C)=O.CN(C)C=O.NC(=O)OCC1=C(C(=O)O)N2C(=O)C(N)[C@H]2SC1.O.O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+]>>CC(C)ON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(COC(N)=O)CS[C@H]12)c1csc(NC=O)n1",
        "output": "587"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.O.O=C(Cl)OCC1c2ccccc2-c2ccccc21.O=C1CCC(CO)N1.c1ccncc1>>O=C1CCC(COC(=O)OCC2c3ccccc3-c3ccccc32)N1",
        "output": "144"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)CNc1cc(C(C)C)ccc1CCNS(=O)(=O)c1cc(C#N)ccc1O.Cl.[Na+].[OH-]>>CC(C)c1ccc(CCNS(=O)(=O)c2cc(C#N)ccc2O)c(NCC(=O)O)c1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nn1nc(Sc2ccc(Br)cc2)c2ccccc2c1=O.O=C(Cl)Cc1ccc(Cl)cc1>>O=C(Cc1ccc(Cl)cc1)Nn1nc(Sc2ccc(Br)cc2)c2ccccc2c1=O",
        "output": "450"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)C=O.CNC.O.O=C(O)c1ccc(Nc2nccc(-c3ccc(Cl)cc3)n2)cc1.O=S(Cl)Cl>>CN(C)C(=O)c1ccc(Nc2nccc(-c3ccc(Cl)cc3)n2)cc1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCCCCCCCCCCCCCO.CCOC(C)=O.O=C(O)CNC(=O)OCc1ccccc1>>CCCCCCCCCCCCCCOC(=O)CNC(=O)OCc1ccccc1",
        "output": "47"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.COC(=O)c1cnc2[nH]ccc2c1.ClCCl.O=S(=O)(Cl)c1ccccc1.[Br-].[Na+].[OH-]>>COC(=O)c1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1",
        "output": "354"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1ccccc1OC.ClCCl.O=C(Cl)c1ccccc1Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>CCc1cc(C(=O)c2ccccc2Cl)ccc1OC",
        "output": "61"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N(CCOCc1ccccc1)C1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)S1.CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)c1ccncc1.ClCCl>>CC(C)(C)OC(=O)N(CCOCc1ccccc1)C1=N[C@H]2[C@H](O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@H](O)[C@@H]2O)S1",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN.ClCCl.Clc1ccnc(Cl)n1>>CNc1ccnc(Cl)n1",
        "output": "166"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cc(OCC(=O)OC(C)(C)C)ccc1Cl.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)c1cc(OCC(=O)O)ccc1Cl",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.COc1cc(OC2CCN(C(=O)OC(C)(C)C)CC2)c(F)cc1C(=O)O.Cl.O=C1OCc2ccccc2N1C1CCNCC1>>COc1cc(OC2CCN(C(=O)OC(C)(C)C)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)[C@@H]1CCCN1C(=O)C1(C)CCc2c(C)c(O)c(C)c(C)c2O1.O.O.[Li]O>>Cc1c(C)c2c(c(C)c1O)CCC(C)(C(=O)N1CCC[C@H]1C(=O)O)O2",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCc1oc2ccccc2c1C(=O)N(C)Cc1ccc(-c2ccc(O)c(Br)c2)cc1.CN(C)C=O.N#CCBr.O=C([O-])[O-].[K+].[K+]>>CCCCc1oc2ccccc2c1C(=O)N(C)Cc1ccc(-c2ccc(OCC#N)c(Br)c2)cc1",
        "output": "802"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)Cc1c[nH]c2cccnc12.CO.N>>NC(=O)Cc1c[nH]c2cccnc12",
        "output": "163"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(OCC(=O)OC(C)(C)C)c(-c2ccccc2)c1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(OCC(=O)O)c(-c2ccccc2)c1",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.COCCCl.COc1ccc(C=O)cc1O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>COCCOc1cc(C=O)ccc1OC",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.Cl.N#Cc1cc(CCC(O)C(=O)OCc2ccccc2)ccc1C1CCCCC1.[C].[H][H].[Pd]>>N#Cc1cc(CCC(O)C(=O)O)ccc1C1CCCCC1",
        "output": "186"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(OC2CCN(C(=O)N3CCCC3)C2)c(I)c1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li+].[OH-]>>O=C(O)c1ccc(OC2CCN(C(=O)N3CCCC3)C2)c(I)c1",
        "output": "222"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC1(C)OB(c2ccc3cc(N)ncc3c2)OC1(C)C.CCOC(C)=O.CN(C)c1ccc(P(C(C)(C)C)C(C)(C)C)cc1.CN(C)c1ccc(P(C(C)(C)C)C(C)(C)C)cc1.Cc1cc(C(O)C(F)(F)F)ncc1Br.Cl[Pd]Cl.O=C([O-])[O-].[Na+].[Na+]>>Cc1cc(C(O)C(F)(F)F)ncc1-c1ccc2cc(N)ncc2c1",
        "output": "938"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CN(C)c1ccncc1.Nc1cccc(Br)c1.O=C(Cl)C1CCCCC1>>O=C(Nc1cccc(Br)c1)C1CCCCC1",
        "output": "9"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.Fc1ccc([C@@H]2CCNC[C@H]2COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1.N#CCBr.O=C([O-])[O-].[K+].[K+]>>N#CCN1CC[C@@H](c2ccc(F)cc2)[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1",
        "output": "880"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Brc1cccs1.C#Cc1cc(F)c(N2C[C@H](C)O[C@H](C)C2)c(C=O)c1>>C[C@H]1CN(c2c(F)cc(C#Cc3cccs3)cc2C=O)C[C@@H](C)O1",
        "output": "766"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2.CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)O)cn3)nc2n1C1CCCC1>>CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4C[C@@H]5C[C@H]4CN5C(=O)OC(C)(C)C)cn3)nc2n1C1CCCC1",
        "output": "256"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)=O.CCCCCC.CN(C)C=O.C[Si](C)(C)OCCCCCBr.O=C([O-])[O-].O=[N+]([O-])c1ncc[nH]1.[K+].[K+]>>C[Si](C)(C)OCCCCCn1ccnc1[N+](=O)[O-]",
        "output": "495"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(N2CCC(n3c(=O)[nH]c4cc(F)c(F)cc43)CC2)CCNC1.O=C(Cl)OCCF>>CC1(N2CCC(n3c(=O)[nH]c4cc(F)c(F)cc43)CC2)CCN(C(=O)OCCF)C1",
        "output": "219"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CSc1ccc(B(O)O)cc1.Fc1cc(Br)c(Br)cc1F>>CSc1ccc(-c2cc(F)c(F)cc2Br)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)C1CC1COc1nc2c(F)c(-c3ccc(-c4ccccc4)cc3)c(F)cc2[nH]1.CCOC(C)=O.C[Si](C)(C)O[K]>>O=C(O)C1CC1COc1nc2c(F)c(-c3ccc(-c4ccccc4)cc3)c(F)cc2[nH]1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C=CC[C@@H](CC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1CN=[N+]=[N-].O.O.[N-]=[N+]=[N-].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C=CC[C@@H](CC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1CN",
        "output": "89"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(c2cccnc2)CO1.CN(C)C=O.Cc1cc2c3c([nH]c2cc1Cl)CCN(C)C3.Cc1ccc2[nH]c3c(c2c1Cl)CN(C)CC3.[H-].[Na+]>>Cc1ccc2c(c1Cl)c1c(n2CC(C)(O)c2cccnc2)CCN(C)C1",
        "output": "749"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.O=C(c1ccccc1)c1ccc(O)cc1.c1ccncc1>>CC(=O)Oc1ccc(C(=O)c2ccccc2)cc1",
        "output": "111"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COCOc1ccc(C2=C3c4ccc5c(cnn5S(=O)(=O)c5ccc(C)cc5)c4CC3(Cc3ccccc3)CCC2=O)cc1.Cl>>Cc1ccc(S(=O)(=O)n2ncc3c4c(ccc32)C2=C(c3ccc(O)cc3)C(=O)CCC2(Cc2ccccc2)C4)cc1",
        "output": "755"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)CCN1CCOc2c(cccc2-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)C1.[Na+].[OH-]>>CC(C)Oc1ccc(-c2nc(-c3cccc4c3OCCN(CCC(=O)O)C4)no2)cc1C#N",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.C[O-].Cl.Oc1ccc(CCl)c2cccnc12.[Na+]>>COCc1ccc(O)c2ncccc12",
        "output": "208"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "B.O=C(O)CCc1cccc(OC(F)F)c1>>OCCCc1cccc(OC(F)F)c1",
        "output": "231"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1N.O=C([O-])[O-].O=S=Nc1cccc(C(=O)Cl)c1.[2H]C(Cl)(Cl)Cl.[K+].[K+]>>CCc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1NC(=O)c1cccc(N=S=O)c1",
        "output": "11"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(N2CCC(=O)CC2)cc1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.C[Si](C)(C)[N-][Si](C)(C)C.[Br-].[Na+]>>C=C1CCN(c2ccc(C(=O)OCC)cc2)CC1",
        "output": "601"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C=CCn1c2c(c3cc(Cl)ccc31)CN(C)CC2.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.Fc1ccc(Br)cc1.[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN1CCc2c(c3cc(Cl)ccc3n2CC=Cc2ccc(F)cc2)C1",
        "output": "539"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(F)c(-c2ccc(CO)cc2C2(OC)CCCC2)c1.CS(=O)(=O)Cl.ClCCl>>COc1ccc(F)c(-c2ccc(COS(C)(=O)=O)cc2C2(OC)CCCC2)c1",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1nc2cc(S(=O)(=O)n3cc(C(=O)O)cn3)ccc2n1CC1CCOCC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCC1CCC1>>CC(C)(C)c1nc2cc(S(=O)(=O)n3cc(C(=O)NCC4CCC4)cn3)ccc2n1CC1CCOCC1",
        "output": "621"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)COc1ccc(SCC=C(c2ccc(Br)cc2)c2ccc(Br)cc2)cc1C.Cl.O.[Na+].[OH-]>>Cc1cc(SCC=C(c2ccc(Br)cc2)c2ccc(Br)cc2)ccc1OCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.ClCCl.O=S(=O)(Cl)c1cc(F)c(Br)cc1F>>O=S(=O)(c1cc(F)c(Br)cc1F)N1CCOCC1",
        "output": "99"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COc1cc(F)c(CC(=O)O)c(F)c1.Cl.O=C([O-])O.[Na+]>>COC(=O)Cc1c(F)cc(OC)cc1F",
        "output": "17"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCCC(=O)NCc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CCCCCNCc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1",
        "output": "533"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)CN1Cc2cc(/C=C/C(=O)N(C)Cc3cc4ccccc4n3C)cnc2NC1=O.CCOC(=O)CN1Cc2cc(/C=C/C(=O)N(C)Cc3sc4ccccc4c3C)cnc2NC1=O>>Cc1c(CN(C)C(=O)/C=C/c2cnc3c(c2)CN(CC(=O)O)C(=O)N3)sc2ccccc12",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)CC(C)C.Cc1nc2n(c(=O)c1CCBr)CCS2.O=C([O-])[O-].OC(c1ccc(F)cc1)C1CCNCC1.[I-].[K+].[Na+].[Na+]>>Cc1nc2n(c(=O)c1CCN1CCC(C(O)c3ccc(F)cc3)CC1)CCS2",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)Cn1nc(-c2ccccc2)c2c(Cl)c(-c3ccccc3)nnc21.O=C1CNCCN1>>O=C1CN(C(=O)Cn2nc(-c3ccccc3)c3c(Cl)c(-c4ccccc4)nnc32)CCN1",
        "output": "297"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC[C@H](NC(=O)OC(C)(C)C)C(=O)N1c2ccc(OC)cc2CC1C(=O)OC.CO.ClCCl.O.[Na+].[OH-]>>CC[C@H](NC(=O)OC(C)(C)C)C(=O)N1c2ccc(OC)cc2CC1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)CO.O=[N+]([O-])c1cccc(Cl)c1Oc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>CC(C)(C)COS(=O)(=O)c1ccc(Oc2c(Cl)cccc2[N+](=O)[O-])cc1",
        "output": "197"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCO.C[Si](C)(C)Cl.Nc1ccc2cn[nH]c2c1.Nc1nc(Cl)nc2[nH]ccc12>>Nc1nc(Nc2ccc3cn[nH]c3c2)nc2[nH]ccc12",
        "output": "808"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)n1ncc2ccc(N)cc21.CN(C)C=O.Cc1cccc(C(=O)O)c1[N+](=O)[O-].ClCCCl>>Cc1cccc(C(=O)Nc2ccc3cnn(C(=O)OC(C)(C)C)c3c2)c1[N+](=O)[O-]",
        "output": "50"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCN(CCCN)CC2)c1.O=C(O)C1(c2ccc(F)cc2Cl)CCCC1>>CC(C)C(=O)Nc1cccc(C2CCN(CCCNC(=O)C3(c4ccc(F)cc4Cl)CCCC3)CC2)c1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C/C(=N\\[Si](C)(C)C)O[Si](C)(C)C.CCN(CC)CC.COCCCCC1(CNC(=O)[C@H]2C[C@@H](N)CN(C(=O)OCC3c4ccccc4-c4ccccc43)C2)c2ccccc2Oc2ccccc21.COc1cc(S(=O)(=O)Cl)ccc1O.ClCCl.O=C([O-])O.[Na+]>>COCCCCC1(CNC(=O)[C@H]2C[C@@H](NS(=O)(=O)c3ccc(O)c(OC)c3)CN(C(=O)OCC3c4ccccc4-c4ccccc43)C2)c2ccccc2Oc2ccccc21",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCCCCCCCI.O=C([O-])[O-].O=C1CCc2cc(O)ccc21.[K+].[K+]>>CCCCCCCCOc1ccc2c(c1)CCC2=O",
        "output": "198"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.Cc1ccc([N+](=O)[O-])c(S(=O)(=O)C(C)C)c1.[Fe]>>Cc1ccc(N)c(S(=O)(=O)C(C)C)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1n[nH]c(CC)c1Oc1cc(Cl)cc(Cl)c1.CN(C)C=O.COCCBr.[H-].[H][H].[Na+]>>CCc1nn(CCOC)c(CC)c1Oc1cc(Cl)cc(Cl)c1",
        "output": "577"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COC(=O)c1cc(C)c(C(=O)OC)c([N+](=O)[O-])c1C.O.[Na+].[OH-]>>COC(=O)c1c(C)cc(C(=O)O)c(C)c1[N+](=O)[O-]",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CC(C(=O)N2CCC(C#N)(Cc3ccc(F)cc3)CC2)Oc2cc(Br)c(Cl)cc21.CC1(C)OB(c2cnn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c2)OC1(C)C.Cl[Pd]Cl.O.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(C)OC(=O)N1CC(C(=O)N2CCC(C#N)(Cc3ccc(F)cc3)CC2)Oc2cc(-c3cnn(C(c4ccccc4)(c4ccccc4)c4ccccc4)c3)c(Cl)cc21",
        "output": "971"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.N#CCBr.O.O=C([O-])[O-].Oc1c(Br)cc(-c2c3ccccc3c(Br)c3sc4ccccc4c23)cc1Br.[K+].[K+]>>N#CCOc1c(Br)cc(-c2c3ccccc3c(Br)c3sc4ccccc4c23)cc1Br",
        "output": "802"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H]1COc1ccc(C(F)(F)F)cc1C(=O)/N=c1\\sc(C(C)(C)C)cn1C[C@H]1CCCO1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)c1cn(C[C@H]2CCCO2)/c(=N/C(=O)c2cc(C(F)(F)F)ccc2OC[C@@H]2CCN2)s1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CNC.Cc1nc(Cl)sc1C(=O)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1ccc(F)c(Cl)c1.Cl>>Cc1nc(N(C)C)sc1C(=O)N(Cc1cc(=O)[nH]c2c(F)cccc12)c1ccc(F)c(Cl)c1",
        "output": "558"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)Nc1c(C(=O)OCC)n(C)c2cc(OCc3ccccc3)ccc12.[K+].[OH-]>>CCOC(=O)Nc1c(C(=O)O)n(C)c2cc(OCc3ccccc3)ccc12",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCc1c(OCCCSCC2COC3(CCC(CC(=O)OCC)C3)O2)ccc(C(C)=O)c1O.CO.[Li+].[OH-]>>CCCc1c(OCCCSCC2COC3(CCC(CC(=O)O)C3)O2)ccc(C(C)=O)c1O",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(F)(c2ccccc2)CC1.Cl>>FC1(c2ccccc2)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)c1csc(-c2ncccc2O)n1.Cl.O.[K+].[OH-]>>O=C(O)c1csc(-c2ncccc2O)n1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCNCCCC.CS(C)=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c(F)c1.[K+].[K+]>>CCCCN(CCCC)c1ccc([N+](=O)[O-])cc1F",
        "output": "26"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1nc(Cl)ccc1[N+](=O)[O-].FC1CCNC1>>Cc1nc(N2CCC(F)C2)ccc1[N+](=O)[O-]",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1ccc(Cn2ccnc2)c(OC)c1.[Na+].[OH-]>>COc1cc(C(=O)O)ccc1Cn1ccnc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOc1ccccc1.CN(C)C=O.COc1cc(Cl)c(C(=O)O)cc1Br.Cc1ccccc1.O=S(Cl)Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>CCOc1ccc(C(=O)c2cc(Br)c(OC)cc2Cl)cc1",
        "output": "275"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(CC)CC.CCN=C=NCCCN(C)C.CNOC.Cl.O=C(O)Cc1ccc(OCC2CC2)cc1Br.On1nnc2ccccc21>>CON(C)C(=O)Cc1ccc(OCC2CC2)cc1Br",
        "output": "54"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.CNC.COC(=O)c1ccc2c(c1)C(c1ccc(C=O)cc1)=CCC2.Cl.ClCCCl.[Na+].[Na+].[OH-]>>COC(=O)c1ccc2c(c1)C(c1ccc(CN(C)C)cc1)=CCC2",
        "output": "567"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC1(C)OB(c2ccc(-n3c(C[C@@H]4CCN(C(=O)C5CC5)C4)n[nH]c3=O)c(F)c2)OC1(C)C.Cc1cc(Br)ccc1C#N.ClCCl.Cl[Pd]Cl.O=C([O-])[O-].[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cc(-c2ccc(-n3c(C[C@@H]4CCN(C(=O)C5CC5)C4)n[nH]c3=O)c(F)c2)ccc1C#N",
        "output": "933"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)[O-].COCC[C@@H]1CCCNC1.Cl.O=C(Cl)CCl.O=C([O-])O.[Na+].[Na+]>>COCC[C@@H]1CCCN(C(=O)CCl)C1",
        "output": "125"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCC.CCN1C(=O)COc2ccc(C(O)(C(C)c3ccc(-c4ccc(C(=O)OC)c(Cl)c4)cc3Cl)C(F)(F)F)cc21>>CCN1C(=O)COc2ccc(C(O)(C(C)c3ccc(-c4ccc(C(=O)O)c(Cl)c4)cc3Cl)C(F)(F)F)cc21",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)CC(=O)Nc2c(Cl)cc(CCCCl)cc21.Cl.O=C([O-])[O-].[K+].[K+].c1ccc2c(N3CCNCC3)nsc2c1>>CC1(C)CC(=O)Nc2c(Cl)cc(CCCN3CCN(c4nsc5ccccc45)CC3)cc21",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCCNC(c1ccccc1)(c1ccccc1)c1ccccc1.CC(C)(C)OC(=O)NCCN.CCCCCC.CCOCC.ClC(Cl)Cl.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)OC(=O)NCCNCCNC(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "147"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)[C@H]1C[C@H](N)C1.Cc1c(C(=O)O)cn(-c2cc(C(C)(C)C)cc(C3(C)CC3)c2)c1C(=O)c1ccccc1.Cl.F[P-](F)(F)(F)(F)F>>COC(=O)[C@@H]1C[C@@H](NC(=O)c2cn(-c3cc(C(C)(C)C)cc(C4(C)CC4)c3)c(C(=O)c3ccccc3)c2C)C1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)Cn1ccc2ccccc2c1=O.ClCCl.O=C(O)C(F)(F)F>>O=C(O)Cn1ccc2ccccc2c1=O",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.CCCCCC[C@H]1C(=O)N[C@@]2([C@@H](O)C3C=CCCC3)C(=O)O[C@@]12C.Cc1ccccc1.c1ccncc1>>CCCCCC[C@H]1C(=O)N[C@@]2([C@@H](OC(C)=O)C3C=CCCC3)C(=O)O[C@@]12C",
        "output": "254"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CN.COc1ccc2cc(C=O)ccc2c1Br.ClCCl.O=S(=O)([O-])[O-].[Mg+2]>>CN=Cc1ccc2c(Br)c(OC)ccc2c1",
        "output": "52"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1.O=C(Cl)c1c(Br)ccc2c1OCO2.O=C1CC(=O)N(c2ccc(C(=O)O)cc2)c2ccc3ccccc3c2N1>>O=C1CC(=O)N(c2ccc(NC(=O)c3c(Br)ccc4c3OCO4)cc2)c2ccc3ccccc3c2N1",
        "output": "11"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1.O.O=C(O)c1ccc(Cl)s1>>O=C(NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1)c1ccc(Cl)s1",
        "output": "736"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.C[Si](C)(C)CCOCn1c(CO)nc(Cl)c1Cl.ClCCl.[Cl-].[NH4+].c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCc1nc(Cl)c(Cl)n1COCC[Si](C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1ncccc1C(=O)O.F[P-](F)(F)(F)(F)F.O.O=S(=O)(c1ccc(C(F)(F)F)cc1)N1CCNCC1.On1nnc2ccccc21>>Cc1ncccc1C(=O)N1CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1",
        "output": "256"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.Cc1ccc(Br)cc1.N[C@@H]1CCCC[C@H]1N.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>Cc1ccc(N[C@@H]2CCCC[C@H]2N)cc1",
        "output": "519"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN1CCN(S(=O)(=O)Nc2ccc(CO)cc2)CC1.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CN1CCN(S(=O)(=O)Nc2ccc(C=O)cc2)CC1",
        "output": "179"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCn1ccc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(C(=O)OC)cc34)cc2)n1.[Li+].[OH-]>>CCn1ccc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(C(=O)O)cc34)cc2)n1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CC[C@@H](C(N)=O)N1CC(CO)CC1=O.CS(=O)(=O)Cl.ClCCl>>CC[C@@H](C(N)=O)N1CC(COS(C)(=O)=O)CC1=O",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccccc1.CC(C)=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)c(O)c1.[K+].[K+]>>O=[N+]([O-])c1ccc(Cl)c(OCc2ccccc2)c1",
        "output": "127"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1ccc(Cl)c(OCCn2cnnn2)c1Cl.CO.O.[Na+].[OH-]>>O=C(O)c1ccc(Cl)c(OCCn2cnnn2)c1Cl",
        "output": "5"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1nc(-c2ccc(C=O)s2)cs1.NC12CC3CC(CC(C3)C1)C2>>Cc1nc(-c2ccc(CNC34CC5CC(CC(C5)C3)C4)s2)cs1",
        "output": "691"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(O)CC(=O)O.O=Cc1ccc(Cl)c(F)c1>>O=C(O)C=Cc1ccc(Cl)c(F)c1",
        "output": "12"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)NC(=O)c1cccc(CN2CCN(C(=O)c3ccc([N+](=O)[O-])cc3Cl)CC2)c1.CC(C)O.Cl>>CC(C)(C)NC(=O)c1cccc(CN2CCN(C(=O)c3ccc(N)cc3Cl)CC2)c1",
        "output": "28"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNC(C)(C)C.O=C(Cl)c1ccc([N+](=O)[O-])cc1.c1ccccc1>>CN(C(=O)c1ccc([N+](=O)[O-])cc1)C(C)(C)C",
        "output": "201"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Clc1ccccc1-c1c[nH]nc1-c1cc2c(s1)-c1ccc(Br)cc1OCC2.N#C[Cu]>>N#Cc1ccc2c(c1)OCCc1cc(-c3n[nH]cc3-c3ccccc3Cl)sc1-2",
        "output": "531"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Brc1cccc(-c2ccccc2)c1.COc1cccc(O)c1>>COc1cccc(Oc2cccc(-c3ccccc3)c2)c1",
        "output": "238"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)C1=Nc2sc(Br)nc2C1.O.[K+].[OH-]>>O=C(O)C1=Nc2sc(Br)nc2C1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(C(C)(C)CC=O)cn1>>CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(C(C)(C)CCN2CCOCC2)cn1",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(C)(C)OC(=O)N[C@H]1COCC[C@H]1N.CCN(C(C)C)C(C)C.COc1ccc(CN2Cc3c(F)c(Cl)nc(Cl)c3C2=O)c(OC)c1>>COc1ccc(CN2Cc3c(F)c(N[C@@H]4CCOC[C@@H]4NC(=O)OC(C)(C)C)nc(Cl)c3C2=O)c(OC)c1",
        "output": "70"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.ClCCl.Cl[Pd]Cl.N#Cc1ccc(Cl)nc1Cl.O=C([O-])[O-].O=[N+]([O-])c1cccc(B(O)O)c1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>N#Cc1ccc(-c2cccc([N+](=O)[O-])c2)nc1Cl",
        "output": "865"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C=CCCc2ccccc2)CC1.ClCCl.O=C(O)C(F)(F)F>>N[C@H]1CC[C@H](C=CCCc2ccccc2)CC1",
        "output": "538"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COc1ccc(C(=O)Cl)cc1.ClC(Cl)Cl.ClCCl.O.Oc1ccc(Cl)cc1.[Na+].[OH-]>>COc1ccc(C(=O)Oc2ccc(Cl)cc2)cc1",
        "output": "482"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)CCCCCN.Cl.Cl.O.O=C(O)C=C1c2ccccc2Sc2ccccc21.Oc1cccc2[nH]nnc12.[Cl-].[Na+]>>COC(=O)CCCCCNC(=O)C=C1c2ccccc2Sc2ccccc21",
        "output": "549"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CN(C)C=O.COC(=O)c1ccc(O)c(C)c1.O.O=C([O-])[O-].OCCBr.[Cs+].[Cs+]>>COC(=O)c1ccc(OCCO)c(C)c1",
        "output": "385"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COc1ccccc1C1CC(=O)CC(=O)C1.ClCCl.O>>O=C1CC(=O)CC(c2ccccc2O)C1",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O=C1CCC(CO)CN1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCC1CCC(=O)NC1",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CC(=O)N(C)C.Nc1nc(-c2cccnc2)c(-c2ccccc2)s1.O>>CC(=O)Nc1nc(-c2cccnc2)c(-c2ccccc2)s1",
        "output": "553"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCC[C@@H](O)c1cccc(O)c1.CS(=O)(=O)OCC1CCN(S(C)(=O)=O)CC1.Oc1ccccc1>>CC(C)(C)OC(=O)NCC[C@@H](O)c1cccc(OCC2CCN(S(C)(=O)=O)CC2)c1",
        "output": "702"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(OCC1(c2ccc(F)cc2)CCN(C(=O)OC(C)(C)C)CC1)c1cc(C2CC2)cc2cn(COCC[Si](C)(C)C)nc12.CC(OCC1(c2ccc(F)cc2)CCN(C(=O)OC(C)(C)C)CC1)c1cc(C2CC2)cc2cn[nH]c12.O=C(O)C(F)(F)F>>CC(OCC1(c2ccc(F)cc2)CCNCC1)c1cc(C2CC2)cc2cn[nH]c12",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=[N+]([O-])c1cc(Oc2ccnc3[nH]ccc23)ccc1O.[Pd]>>Nc1cc(Oc2ccnc3[nH]ccc23)ccc1O",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(-c2cc[nH]c(=O)c2)cn1.Cn1c2c(c3ccc(Br)cc31)CN(C(=O)OC(C)(C)C)CC2>>Cc1ccc(-c2ccn(-c3ccc4c5c(n(C)c4c3)CCN(C(=O)OC(C)(C)C)C5)c(=O)c2)cn1",
        "output": "982"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1c(-c2ccc(S(C)(=O)=O)cc2)cnn(-c2cccc(Cl)c2)c1=O.Cl.[Na+].[OH-]>>CS(=O)(=O)c1ccc(-c2cnn(-c3cccc(Cl)c3)c(=O)c2O)cc1",
        "output": "424"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CNCCO.O=C=NCc1ccccc1Cl>>CN(CCO)C(=O)NCc1ccccc1Cl",
        "output": "583"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Br.CC(=O)O.CCOC(C)=O.CO.COc1ccc(Oc2cccc(C(=O)O)c2)cc1>>O=C(O)c1cccc(Oc2ccc(O)cc2)c1",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(c1c(Cl)ccc(F)c1Cl)c1c[nH]c2ncc(Br)cc12.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.[K+]>>CC(c1c(Cl)ccc(F)c1Cl)c1c[nH]c2ncc(B3OC(C)(C)C(C)(C)O3)cc12",
        "output": "943"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCc1ccc(F)cc1.CCN(C(C)C)C(C)C.CN(C)C=O.Cn1c(=O)n(Cc2ccc(F)c(F)c2)c(=O)c2cc(I)ccc21.O.[Cu]I>>Cn1c(=O)n(Cc2ccc(F)c(F)c2)c(=O)c2cc(C#CCc3ccc(F)cc3)ccc21",
        "output": "664"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)Nc1nc(N)cc2ccn(CCO)c(=O)c12.CC(C)(C)[O-].CC(C)(N)c1ccnc(Cl)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)Nc1nc(Nc2cc(C(C)(C)N)ccn2)cc2ccn(CCO)c(=O)c12",
        "output": "606"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCC1CC(c2cccc(Cl)c2)C(c2ccc(Cl)cc2)N(C(CC)CN)C1=O.CC(=O)OC(C)=O.CN(C)C=O>>C=CCC1CC(c2cccc(Cl)c2)C(c2ccc(Cl)cc2)N(C(CC)CNC(C)=O)C1=O",
        "output": "339"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(Cl)Cl.CC(Cl)OC(=O)Cl.CO.O=C1NCc2ccccc2N1C1CCN(Cc2ccccc2)CC1.[NH4+].[OH-]>>O=C1NCc2ccccc2N1C1CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCc1c[nH]c2ccc(C(=O)O)cc12.CCN(CC)CC.CCc1cccc(CNC[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)c1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F>>CCCCc1c[nH]c2ccc(C(=O)N[C@@H](Cc3cc(F)cc(F)c3)[C@H](O)CNCc3cccc(CC)c3)cc12",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Br.CCOCC.CC[C@@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1c1cnc2cnc3c(ccn3S(=O)(=O)c3ccc(C)cc3)n12.ClCCl.O>>CC[C@H]1CNC[C@H]1c1cnc2cnc3c(ccn3S(=O)(=O)c3ccc(C)cc3)n12",
        "output": "428"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C(C)(c1ccc(-c2ccc(C(F)(F)F)nn2)cc1)c1ccc(B2OC(C)(C)C(C)(C)O2)cn1.CCO.COc1cncc(Br)c1.Cc1ccccc1.Cl[Pd]Cl.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1cncc(-c2ccc(C(C)(c3ccc(-c4ccc(C(F)(F)F)nn4)cc3)C(C)C)nc2)c1",
        "output": "967"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccccc1N1CCOCC1.ClCCl.O=S(=O)(O)Cl>>COc1ccc(S(=O)(=O)Cl)cc1N1CCOCC1",
        "output": "182"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc(CCc2nc3c(N4CCNCC4)nc(N)nc3s2)cc1.O=C(O)COc1ccc(Cl)cc1>>Cc1ccc(CCc2nc3c(N4CCN(C(=O)COc5ccc(Cl)cc5)CC4)nc(N)nc3s2)cc1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(N)CC1.ClCCl.O=C=Nc1c(F)cc(Cl)cc1Br>>CC(C)(C)OC(=O)N1CCC(NC(=O)Nc2c(F)cc(Cl)cc2Br)CC1",
        "output": "35"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)c1ccc(Cc2ccc(OC)cc2)cn1.Cl>>CCOC(=O)c1ccc(Cc2ccc(O)cc2)cn1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCCCCCCc1ccc(OCc2ccccc2)c(OCc2ccccc2)c1.CC(C)=O.CCOC(=O)[C@@H](C)c1ccc2cc(O)ccc2c1.CN(C)C=O.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CCOC(=O)[C@@H](C)c1ccc2cc(OCCCCCCc3ccc(OCc4ccccc4)c(OCc4ccccc4)c3)ccc2c1",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=[N+]([O-])c1cnc2ccccc2c1NCc1cc(-c2cccnc2)on1.[Pt]>>Nc1cnc2ccccc2c1NCc1cc(-c2cccnc2)on1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.COc1ccc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)cc1F.ClCCl>>O=S(=O)(Nc1ccc2c(c1)B(O)OC2)c1ccc(O)c(F)c1",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.C=Cc1ccc(B(O)O)cc1.CC(C)(C)P.Clc1ccccc1-c1ccccn1.F[K].O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Pd]>>C=Cc1ccc(-c2ccccc2-c2ccccn2)cc1",
        "output": "892"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CCOCC.O=C([O-])[O-].O=Cc1ccc(O)cc1.OCCBr.[K+].[K+]>>O=Cc1ccc(OCCO)cc1",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=C(O)c1ccc(-c2ncccc2C(F)(F)F)cc1[N+](=O)[O-].[Pd]>>Nc1cc(-c2ncccc2C(F)(F)F)ccc1C(=O)O",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.CC[C@@H]1CCCCN1.Cc1ccccc1.Cl.O=C(O)c1cc2ccccc2c(-c2ccccc2)n1>>CC[C@@H]1CCCCN1C(=O)c1cc2ccccc2c(-c2ccccc2)n1",
        "output": "605"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(F)C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COC(=O)c1ccc2c(c1)[C@H](N)CC2.F[P-](F)(F)(F)(F)F>>COC(=O)c1ccc2c(c1)[C@H](NC(=O)C(C)(C)F)CC2",
        "output": "599"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC[C@H](O)C1.C[Si](C)(C)[N-][Si](C)(C)C.O=[N+]([O-])c1ccc(F)cc1F.[Li+]>>CC(C)(C)OC(=O)N1CCC[C@H](Oc2cc(F)ccc2[N+](=O)[O-])C1",
        "output": "485"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)c1cc(-c2ccc(F)c(C)c2)n[nH]c1=O.ClCc1ccccc1>>COC(=O)c1cc(-c2ccc(F)c(C)c2)nn(Cc2ccccc2)c1=O",
        "output": "842"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.CC(C)(C)C(=O)Cl.CCN(CC)CC.ClCCl.NCCCBr>>CC(C)(C)C(=O)NCCCBr",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C1CC(c2ccc(C(F)(F)F)cc2)Oc2ccc(O)cc21.Oc1ccc2c(c1)C(O)CC(c1ccccc1)O2>>Oc1ccc2c(c1)C(O)CC(c1ccc(C(F)(F)F)cc1)O2",
        "output": "24"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C.O.O.[Li]O>>CC(C)(C)OC(=O)CC[C@H](NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCC(=O)c1cc2c(=O)n(NS(C)(=O)=O)c(=O)[nH]c2cc1C(F)(F)F.CCOC(C)=O.CO.Cl.O.[BH4-].[Na+]>>CCCC(O)c1cc2c(=O)n(NS(C)(=O)=O)c(=O)[nH]c2cc1C(F)(F)F",
        "output": "24"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C(O)c1ccc(Cl)cc1O>>O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(Cl)cc1O",
        "output": "50"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC[C@@H](CO)Nc1nc(N)nc(C)c1Cc1ccc(C(=O)O)cc1OC.CO>>CCC[C@@H](CO)Nc1nc(N)nc(C)c1Cc1ccc(CO)cc1OC",
        "output": "72"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.C[Si](C)(C)CCOCCl.Clc1ccnc2[nH]ccc12.[H-].[Na+]>>C[Si](C)(C)CCOCn1ccc2c(Cl)ccnc21",
        "output": "712"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)NC(Cc1ccc(OCc2ccccc2)cc1)C(=O)O.CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CNOC.Cl.F[P-](F)(F)(F)(F)F>>CON(C)C(=O)C(Cc1ccc(OCc2ccccc2)cc1)NC(=O)OC(C)(C)C",
        "output": "54"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.Cc1ccc(-n2cc(C(=O)N3CCNC(=O)C3)nc2-c2ccc(C)nc2)cc1.[H-].[Na+]>>Cc1ccc(-n2cc(C(=O)N3CCN(C)C(=O)C3)nc2-c2ccc(C)nc2)cc1",
        "output": "83"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cn2c(cc1=O)-c1cc(Cl)c(OCCCOC)cc1CC2C1(C)CC1.CO.Cl.O.O.[Li]O>>COCCCOc1cc2c(cc1Cl)-c1cc(=O)c(C(=O)O)cn1C(C1(C)CC1)C2",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCCN(CCC)CCCCN.CN(C)C=O.Cn1ccnc1CN(Cc1ccc(C(=O)O)cc1)Cc1nccn1C.On1nnc2ccccc21>>CCCN(CCC)CCCCNC(=O)c1ccc(CN(Cc2nccn2C)Cc2nccn2C)cc1",
        "output": "821"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.Nc1ccc(C(F)(F)F)cc1.O=C=O.[Li]CCCC>>Nc1ccc(C(F)(F)F)cc1C(=O)O",
        "output": "387"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)c1ccc(Cl)nc1.CO.C[O-].[Na+]>>COc1ccc(C(C)=O)cn1",
        "output": "433"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.Cc1ccc(C(=O)Cl)cc1[N+](=O)[O-].ClCCl.Nc1ccc(F)c(Cl)c1.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(C(=O)Nc2ccc(F)c(Cl)c2)cc1[N+](=O)[O-]",
        "output": "11"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CCOC(C)=O.Fc1ccc(C2CCC3(CC2)OCCO3)cc1Cl.O=S(=O)(O)O>>O=C1CCC(c2ccc(F)c(Cl)c2)CC1",
        "output": "251"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CC[C@@H]1COCCN1c1cc(-c2cc(F)c(C#N)c(F)c2)nc(NC)n1.CN(C)C=O.CO.C[O-].[H-].[Na+].[Na+]>>CC[C@@H]1COCCN1c1cc(-c2cc(F)c(C#N)c(OC)c2)nc(NC)n1",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCCNCC1.ClCCl.O=C(O)CC1CCCc2c1cnn2-c1ccccc1.O=C(n1ccnc1)n1ccnc1>>O=C(CC1CCCc2c1cnn2-c1ccccc1)N1CCCCCC1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.COc1ccc(C#N)cc1/C=C(\\C#N)c1c[nH]c2ccc(Br)cc12.O>>COc1ccc(C#N)cc1/C=C(\\C#N)c1cn(C(=O)OC(C)(C)C)c2ccc(Br)cc12",
        "output": "748"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CSCCN1.CS(C)=O.Cc1cc(Cl)nc(=N)n1O>>Cc1cc(N2CCSCC2)nc(=N)n1O",
        "output": "162"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "N#Cc1cc(N)ccc1N1CCCCC1.O=C(O)c1cc2ccccc2s1>>N#Cc1cc(NC(=O)c2cc3ccccc3s2)ccc1N1CCCCC1",
        "output": "822"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(C(=O)Oc1ccc(F)cc1)[C@@H]1CN(C(=O)C2CCN(c3ccc(C(C)=O)cn3)CC2)C[C@H]1c1ccc(Cl)cc1.O.[BH4-].[Na+]>>CCN(C(=O)Oc1ccc(F)cc1)[C@@H]1CN(C(=O)C2CCN(c3ccc(C(C)O)cn3)CC2)C[C@H]1c1ccc(Cl)cc1",
        "output": "449"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.COc1ccc(B(O)O)cc1.Cc1c(Cc2ccccc2)c2cc(Br)ccc2n1C.ClCCl.Cl[Pd]Cl.O=C([O-])[O-].[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1ccc(-c2ccc3c(c2)c(Cc2ccccc2)c(C)n3C)cc1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)c1ccc(N)cc1.O=S(=O)(O)O.O=[N+]([O-])O>>CC(C)c1ccc(N)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1Cc2ccc(Br)cc2C1>>CC(C)(C)OC(=O)NC1Cc2ccc(Br)cc2C1",
        "output": "631"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCCc1nc(CC)cc(=O)[nH]1.N#Cc1ccccc1-c1ccc(CBr)cc1.O=C([O-])[O-].[K+].[K+]>>CCCc1nc(CC)cc(=O)n1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "389"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN1CCC(C(=O)Cl)(c2ccccc2)CC1.ClCCl.NCc1ccccc1.O.O=C([O-])[O-].[K+].[K+]>>CN1CCC(C(=O)NCc2ccccc2)(c2ccccc2)CC1",
        "output": "206"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.Cl.ClCCl.O=C(Cl)OCc1ccccc1.O=C1c2c(ccc3c2CCNCC3)CC1(F)F>>O=C(OCc1ccccc1)N1CCc2ccc3c(c2CC1)C(=O)C(F)(F)C3",
        "output": "427"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=O.CC(=O)O.CO.ClCCl.Fc1cc2ncccc2cc1Cc1cnc2ccc(-c3cnn(C4CCNCC4)c3)nn12.[BH3-]C#N.[Na+]>>CN1CCC(n2cc(-c3ccc4ncc(Cc5cc6cccnc6cc5F)n4n3)cn2)CC1",
        "output": "217"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=CC(=O)Cl.Nc1c(C(O)(C(F)(F)F)C(F)(F)F)ccc2ccccc12>>CC(C)=CC(=O)Nc1c(C(O)(C(F)(F)F)C(F)(F)F)ccc2ccccc12",
        "output": "10"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "N#Cc1ccc2[nH]cc(CCCCCl)c2c1.NC(=O)c1cc2cc(N3CCNCC3)ccc2o1.O.O=C([O-])[O-].[K+].[K+]>>N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5oc(C(N)=O)cc5c4)CC3)c2c1",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1.CCNc1ccc2c(c1)nc(C(C)(C)C)n2CC1CCOCC1.CCOC(C)=O.CN(C)c1ccncc1.Cl>>CCN(c1ccc2c(c1)nc(C(C)(C)C)n2CC1CCOCC1)S(=O)(=O)c1ccc(NC(C)=O)cc1",
        "output": "791"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C[Si](C)(C)C#N.[O-][n+]1ccc(Br)cc1>>N#Cc1cc(Br)ccn1",
        "output": "720"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1csc(Br)n1.CC(=O)N1CCNCC1.CCN(CC)CC.CN(C)C=O.O>>CC(=O)N1CCN(c2nc(Br)cs2)CC1",
        "output": "657"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CC[C@H](N)c1cc2cccc(Cl)c2c(=O)n1C1CC1.Cc1nc(-c2c(N)ncnc2Cl)no1>>CC[C@H](Nc1ncnc(N)c1-c1noc(C)n1)c1cc2cccc(Cl)c2c(=O)n1C1CC1",
        "output": "110"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1cnc(N2CCNCC2)c(Cl)c1.O=C=Nc1ccc(Cl)c(Cl)c1>>CCOC(=O)c1cnc(N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)c(Cl)c1",
        "output": "323"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(-c2ccc(C(F)(F)F)cc2)nc(-n2cnc(-c3ccc(S(=O)(=O)NC(C)(C)C)s3)c2)n1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(-c2ccc(C(F)(F)F)cc2)nc(-n2cnc(-c3ccc(S(N)(=O)=O)s3)c2)n1",
        "output": "680"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=C[C@H]1CNCC[C@H]1CCC(=O)c1ccnc2ccc(OC)cc12.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(C)=O.ClCCl.O>>C=C[C@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1CCC(=O)c1ccnc2ccc(OC)cc12",
        "output": "694"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NC1CC1.O=C(O)c1ccncc1Nc1ccc(I)cc1F>>O=C(NC1CC1)c1ccncc1Nc1ccc(I)cc1F",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=O.CC#N.CCN(CC)CC.Cc1ccc(C)c(O)c1.[Cl-].[Cl-].[Mg+2]>>Cc1ccc(C)c(C=O)c1O",
        "output": "451"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.COc1ccc(NC(=O)c2cc(CN)ccc2Cl)cc1C(=O)Nc1ccc(Br)cc1.O=S(=O)(Cl)C1CC1.c1ccncc1>>COc1ccc(NC(=O)c2cc(CNS(=O)(=O)C3CC3)ccc2Cl)cc1C(=O)Nc1ccc(Br)cc1",
        "output": "742"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCCCC(C=Cc1ccc(C(=O)OC)cc1)c1ccc2c(c1)N(C)CCC2(C)C.CO.Cl.O.O.[Li+].[OH-]>>CCCCCC(C=Cc1ccc(C(=O)O)cc1)c1ccc2c(c1)N(C)CCC2(C)C",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cnc(SC)nc1Nc1cc(C(C)(C)C)nn1-c1cc(C)ccc1C.Cl.O.O.[Li+].[OH-]>>CSc1ncc(C(=O)O)c(Nc2cc(C(C)(C)C)nn2-c2cc(C)ccc2C)n1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCOc1ccc(-c2scc(-c3ccccc3Cl)c2CC(=O)OC)cc1.CCO.Cl.[Na+].[OH-]>>CCCOc1ccc(-c2scc(-c3ccccc3Cl)c2CC(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCNC(=O)NN(C)CC(=O)O.CCOC(OCC)[C@H](C)N(Cc1csc2ccccc12)C(=O)[C@H](C)N>>CCNC(=O)NN(C)CC(=O)N[C@@H](C)C(=O)N(Cc1csc2ccccc12)[C@@H](C)C(OCC)OCC",
        "output": "133"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1cc(C#N)c(SC)nc1O.O.O.[Li+].[OH-]>>CSc1nc(O)c(C(=O)O)cc1C#N",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN=C=NCCCN(C)C.Cl.NC(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1cccc(Cl)c1.O.O.O=C(O)c1cccc2c1C=CCCC2.On1nnc2ccccc21>>O=C(NC(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1cccc(Cl)c1)c1cccc2c1C=CCCC2",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)Cc1ccc(C(C)C(=O)O)cc1.CCCO.O=S(=O)(O)O>>CCCOC(=O)C(C)c1ccc(CC(C)C)cc1",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.COC(=O)C(CCO)Oc1ccc(Cl)cc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>COC(=O)C(CCOS(=O)(=O)c1ccc(C)cc1)Oc1ccc(Cl)cc1",
        "output": "197"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc2c3c1O[C@H]1[C@@]4(OC)CC[C@@]5(C[C@@H]4CSCc4ccccc4)[C@@H](C2)N(CC2CC2)CC[C@]315.ClCCl.O=C(OO)c1cccc(Cl)c1>>COc1ccc2c3c1O[C@H]1[C@@]4(OC)CC[C@@]5(C[C@@H]4CS(=O)Cc4ccccc4)[C@@H](C2)N(CC2CC2)CC[C@]315",
        "output": "13"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)c1cc(NC(=O)Oc2ccccc2)n(-c2cccc(F)c2)n1.Cn1ncc2c(-c3ccc(N)cc3)cncc21.Nc1cc[nH]n1.O=C(Cl)Oc1ccccc1.c1ccncc1>>CC(C)c1cc(NC(=O)Nc2ccc(-c3cncc4c3cnn4C)cc2)n(-c2cccc(F)c2)n1",
        "output": "948"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.COc1cc2nc(N(C)CC3(c4ccccc4)CCNCC3)nc(N)c2cc1OC.O=C(Cl)C1CC1.O=C([O-])O.[Na+]>>COc1cc2nc(N(C)CC3(c4ccccc4)CCN(C(=O)C4CC4)CC3)nc(N)c2cc1OC",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)[Si](C(C)C)(C(C)C)C1(CO)c2ccccc2-c2ccccc21.CCN(CC)CC.O=C=Nc1ccccc1.c1ccccc1>>CC(C)[Si](C(C)C)(C(C)C)C1(COC(=O)Nc2ccccc2)c2ccccc2-c2ccccc21",
        "output": "34"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CN(C)C.COc1ccc(C2CC(=O)N(c3cccc(C(N)=O)c3)C2)c(O)c1.ClCCl.OB(O)c1cccc(Cl)c1.[Cu+2]>>COc1ccc(C2CC(=O)N(c3cccc(C(N)=O)c3)C2)c(Oc2cccc(Cl)c2)c1",
        "output": "920"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCNC(=O)c1ccc(C)c(-c2nc(S(C)(=O)=O)nc3c2CNC(=O)N3c2c(F)cccc2F)c1.CCN(CC)CC.CCN(CCCN)C(=O)OC(C)(C)C.CCOC(C)=O.CN(C)C=O>>CCCNC(=O)c1ccc(C)c(-c2nc(NCCCN(CC)C(=O)OC(C)(C)C)nc3c2CNC(=O)N3c2c(F)cccc2F)c1",
        "output": "629"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CCOC(=O)c1ccc(N2CCC3(CC2)OCCO3)cc1>>CCOC(=O)c1ccc(N2CCC(=O)CC2)cc1",
        "output": "251"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)CNC(=O)C1=C(O)c2cc(F)c(F)cc2C(C)(C)C1=O.O=C(O)C(F)(F)F>>CC1(C)C(=O)C(C(=O)NCC(=O)O)=C(O)c2cc(F)c(F)cc21",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(S(=O)(=O)OC2CCN(c3cccc(C(F)(F)F)c3Cl)C2)cc1.OC1CCN(c2cccc(C(F)(F)F)c2)C1.OC1CCN(c2cccc(C(F)(F)F)c2Cl)C1>>Cc1ccc(S(=O)(=O)OC2CCN(c3cccc(C(F)(F)F)c3)C2)cc1",
        "output": "253"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Cc1cccc(Cn2nc(C)c3c(NC(=O)c4cnc5cc(OCCN6CCN(C(=O)OC(C)(C)C)CC6)ccn45)cccc32)n1.Cl>>Cc1cccc(Cn2nc(C)c3c(NC(=O)c4cnc5cc(OCCN6CCNCC6)ccn45)cccc32)n1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)CC=O.CCN(CC)CC.CCOC(=O)[C@@H]1CCCC[C@@H]1N.CO.Cl.[BH3-]C#N.[Na+]>>CCOC(=O)[C@@H]1CCCC[C@@H]1NCCC(C)(C)C",
        "output": "426"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCC(=O)Cl.CCN(CC)CC.Cl.ClCCl.O.c1ccc(CCc2csc(C3CCNCC3)n2)cc1>>CCCCC(=O)N1CCC(c2nc(CCc3ccccc3)cs2)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.CO.ClCCl.O=C(c1ccccc1)N1CCN(c2ccc(OCC3CCNCC3)cc2)CC1.[Na+]>>CC(C)N1CCC(COc2ccc(N3CCN(C(=O)c4ccccc4)CC3)cc2)CC1",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(B3OC(C)(C)C(C)(C)O3)cc12.COc1ncc(Br)cc1-c1nc2c(F)cccc2o1.Cl[Pd]Cl.O=P([O-])([O-])[O-].[Fe+2].[K+].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3cnc(OC)c(-c4nc5c(F)cccc5o4)c3)cc12",
        "output": "938"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C([O-])[O-].OCC1CCCCN1.[K+].[K+]>>OCC1CCCCN1Cc1ccccc1",
        "output": "248"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cc1ccccc1.Cl.N.O=C(O)c1ccc(C(F)(F)F)cc1O.O=S(Cl)Cl>>NC(=O)c1ccc(C(F)(F)F)cc1O",
        "output": "358"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.Cc1ccc(S(=O)(=O)Nc2ccc(SC#N)cc2)cc1.O.O=[N+]([O-])O>>Cc1ccc(S(=O)(=O)Nc2ccc(SC#N)cc2[N+](=O)[O-])cc1",
        "output": "21"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.Cc1cc(Br)c(F)cc1N>>CC(=O)Nc1cc(F)c(Br)cc1C",
        "output": "6"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C(O)c1cc(Oc2ccc([N+](=O)[O-])cc2)cc(Oc2ccc([N+](=O)[O-])cc2)c1.O=S(Cl)Cl>>O=C(Cl)c1cc(Oc2ccc([N+](=O)[O-])cc2)cc(Oc2ccc([N+](=O)[O-])cc2)c1",
        "output": "3"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCCCON1C(C)(C)CC(O)CC1(C)C.COC(=O)CS.Cc1ccccc1.[Li+].[NH2-]>>CCCCCCCCON1C(C)(C)CC(OC(=O)CS)CC1(C)C",
        "output": "289"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Br.Br.CC(C)O.CS(C)=O.Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C(F)(F)F)c(F)n2)n1.O=C([O-])[O-].OC1CNCCNC1.[Cs+].[Cs+]>>Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C(F)(F)F)c(N3CCNCC(O)C3)n2)n1",
        "output": "756"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)NC1CCN(C(=O)OC(C)(C)C)C1.Cl>>COC(=O)NC1CCNC1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.COc1cccc(CO)c1.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.[Na+]>>COc1cccc(COC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)c1",
        "output": "960"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)NS(=O)(=O)c1cccc(B(O)O)c1.Cc1cc(-c2ccc(C(F)(F)F)cc2)nc(-c2cccc(Br)c2)n1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)nc(-c2cccc(-c3cccc(S(=O)(=O)NC(C)(C)C)c3)c2)n1",
        "output": "837"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Nc1cc(N2CCNCC2)c(F)cc1[N+](=O)[O-].[Pd]>>Nc1cc(F)c(N2CCNCC2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.C=CCC1=C(C)CC(O[Si](C)(C)C(C)(C)C)C1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>C=CCC1=C(C)CC(O)C1",
        "output": "708"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCN(CCC)c1nc2c(c(-c3ccc(OCc4ccccc4)cc3F)cn2C)c(=O)n1C.[Pd]>>CCCN(CCC)c1nc2c(c(-c3ccc(O)cc3F)cn2C)c(=O)n1C",
        "output": "23"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCOC(C)=O.Cc1[nH]c2ccc(O)c(C(F)(F)F)c2c1C(=O)OC(C)(C)C.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1[nH]c2ccc(OS(=O)(=O)C(F)(F)F)c(C(F)(F)F)c2c1C(=O)OC(C)(C)C",
        "output": "843"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(O)c1ccn2c(Br)cnc2c1F.CC1(C)OB(c2cc(-c3ccccc3C#N)ccc2F)OC1(C)C>>CC(C)(O)c1ccn2c(-c3cc(-c4ccccc4C#N)ccc3F)cnc2c1F",
        "output": "937"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CN(C)C=O.COCCCI.COc1c(O)cc(I)nc1I.O.[Na+].[OH-]>>COCCCOc1cc(I)nc(I)c1OC",
        "output": "198"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCCN(C)C.CCOCC.CN(C)c1ccncc1.ClCCl.Fc1ccc(OC2CCNCC2)cc1F.O=C(O)CN1CCCC(c2ccccc2)(c2ccccc2)C1=O>>O=C(CN1CCCC(c2ccccc2)(c2ccccc2)C1=O)N1CCC(Oc2ccc(F)c(F)c2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Cl.CC1(C)CCSc2ccccc21.ClCCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)c1ccc2c(c1)C(C)(C)CCS2",
        "output": "31"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CC[Si](Cl)(CC)CC.CN(C)C=O.OCc1c(Br)sc2c(-c3cccnc3)ncn12>>CC[Si](CC)(CC)OCc1c(Br)sc2c(-c3cccnc3)ncn12",
        "output": "193"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C(O)c1cc2ncc(Cl)cn2n1.c1cncc(-c2ccc3n2CCNC3)c1>>O=C(c1cc2ncc(Cl)cn2n1)N1CCn2c(ccc2-c2cccnc2)C1",
        "output": "663"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CNC1CCC2(CC1)OCCO2.ClCCl.O.O=Cc1ccccc1.[Na+]>>CN(Cc1ccccc1)C1CCC2(CC1)OCCO2",
        "output": "567"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.O=Cc1cc(Br)ccc1OCCN1CCCC1.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[Li+].[NH4+]>>OCc1cc(Br)ccc1OCCN1CCCC1",
        "output": "356"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCS(=O)(=O)c1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1ccccc1.ClCCl.O=C(OO)c1cccc(Cl)c1>>CCCS(=O)(=O)c1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCS(=O)c1ccccc1",
        "output": "500"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc3cc(C(=O)O)ncc3c2C2CC2)CC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Nc1ccccc1N.On1nnc2cccnc21>>CC(C)(C)OC(=O)N1CCN(c2ccc3cc(C(=O)Nc4ccccc4N)ncc3c2C2CC2)CC1",
        "output": "548"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CNC(=S)C1(n2cnc([N+](=O)[O-])c2)CCCCC1=O.CO.O.[BH4-].[Cl-].[NH4+].[Na+]>>CNC(=S)C1(n2cnc([N+](=O)[O-])c2)CCCCC1O",
        "output": "91"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCI.CN(C)C=O.COc1cc(-c2c(-c3ccncc3)nn3c(C4CC5CCC(C4)N5)ccnc23)ccc1Cl.O.O=C([O-])[O-].[K+].[K+]>>CCN1C2CCC1CC(c1ccnc3c(-c4ccc(Cl)c(OC)c4)c(-c4ccncc4)nn13)C2",
        "output": "184"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#CCC(O)C(C)(C)CCC.CC[Si](Cl)(CC)CC.CN(C)C=O.c1c[nH]cn1>>C#CCC(O[Si](CC)(CC)CC)C(C)(C)CCC",
        "output": "193"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)c1ccc(N2CCCS2(=O)=O)cc1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)c1ccc(N2CCCS2(=O)=O)cc1",
        "output": "752"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "N#Cc1ccc(Cl)cc1.OCC(F)(F)C(F)F.[H-].[Na+]>>N#Cc1ccc(OCC(F)(F)C(F)F)cc1",
        "output": "57"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCNCC1.CCO.Cc1c(C(=O)N2C[C@H](C)N[C@H](C)C2)c[nH]c1C=O.O=C1Cc2c(cccc2-c2ccc(F)cc2)N1>>Cc1c(C(=O)N2C[C@H](C)N[C@H](C)C2)c[nH]c1C=C1C(=O)Nc2cccc(-c3ccc(F)cc3)c21",
        "output": "440"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc2c(c1)nc(NCCCN(C)CCCNC(=O)OC(C)(C)C)n[n+]2[O-].Cl>>Cc1ccc2c(c1)nc(NCCCN(C)CCCN)n[n+]2[O-]",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=C(CCc1ncc(-c2ccc([N+](=O)[O-])cc2)cn1)NCC1CCN(Cc2cccc(Cl)c2Cl)C1.[H][H].[Pd]>>Nc1ccc(-c2cnc(CCC(=O)NCC3CCN(Cc4cccc(Cl)c4Cl)C3)nc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(Cc2c(-c3ccc(Cl)cc3)nc3ccc(-c4ccccc4)cn23)CC1.ClCCl.O=C(O)C(F)(F)F>>Clc1ccc(-c2nc3ccc(-c4ccccc4)cn3c2CN2CCNCC2)cc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br.BrBr.CC(=O)O.CC(=O)c1ccc(F)c(S(N)(=O)=O)c1>>NS(=O)(=O)c1cc(C(=O)CBr)ccc1F",
        "output": "173"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)c1cccc(CN2CN(C3CCCCC3)C3(CCNCC3)C2=O)c1.CCOC(C)=O.CN(C)C=O.O=C(CCCI)c1ccccc1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)c1cccc(CN2CN(C3CCCCC3)C3(CCN(CCCC(=O)c4ccccc4)CC3)C2=O)c1",
        "output": "184"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.Clc1nc(N2CCOCC2)c2ncnc(NCc3ccccc3)c2n1.OCCN1CCNCC1>>OCCN1CCN(c2nc(N3CCOCC3)c3ncnc(NCc4ccccc4)c3n2)CC1",
        "output": "36"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCCc1cccs1.CN(C)C=O.[Li]CCCC>>CC(C)(C)[Si](C)(C)OCCc1ccc(C=O)s1",
        "output": "617"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CO.COc1cc(S(=O)(=O)c2ccccc2)ccc1[N+](=O)[O-].O.O=C[O-].[NH4+].[Pd]>>COc1cc(S(=O)(=O)c2ccccc2)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCCCC1.CC(=O)Cl.CC(C=CC1CCCC1)CCO.CN(C)c1ccncc1.COC(C)(C)C.Cl.c1ccncc1>>CC(=O)OCCC(C)C=CC1CCCC1",
        "output": "126"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.COc1ccc(C)cc1S(=O)(=O)Oc1cc(C)cc(O)c1.OCCCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(C)cc1S(=O)(=O)Oc1cc(C)cc(OCCCO)c1",
        "output": "478"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC[C@@]12CO[C@@](c3ccc(Cl)c(Cc4ccc(C(C)=O)cc4)c3)(O1)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]2OC(C)=O.CCO.CCON.Cl.c1ccncc1>>CCON=C(C)c1ccc(Cc2cc([C@]34OC[C@](COC(C)=O)(O3)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]4OC(C)=O)ccc2Cl)cc1",
        "output": "212"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClCCl.N=C=N.O=C(O)CCc1cnoc1-c1cccc(Cl)c1.OC1CCNCC1>>O=C(CCc1cnoc1-c1cccc(Cl)c1)N1CCC(O)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.Cc1ccc(N)c(B2OC(C)(C)C(C)(C)O2)c1.ClCCl.c1ccncc1>>CC(=O)Nc1ccc(C)cc1B1OC(C)(C)C(C)(C)O1",
        "output": "9"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCBr.CN(C)C=O.O=C(O)CC(O)(CC(=O)O)C(=O)O.Oc1ccc(I)cc1.[H-].[Na+]>>BrCCCOc1ccc(I)cc1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C[N+](=O)[O-].Cl.ClCCl.O=C(Cc1ccccc1)OCc1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(O)Cc1ccccc1",
        "output": "186"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1ccc(Cl)cc1C(F)(F)F.O=C1CCC(=O)N1I>>Nc1c(I)cc(Cl)cc1C(F)(F)F",
        "output": "834"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.COc1ccc2nc(Cl)cc(C)c2c1.ClCCl.O=C([O-])O.[Na+]>>Cc1cc(Cl)nc2ccc(O)cc12",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCCOCCOc1ccc(-c2cnc(N3CCC(COC(C)=O)C3)c(/C=C(\\C)C(=O)Nc3ccc(S(=O)Cc4nncn4CCC)cc3)c2)cc1.CO.Cl.O.[Na+].[OH-]>>CCCCOCCOc1ccc(-c2cnc(N3CCC(CO)C3)c(/C=C(\\C)C(=O)Nc3ccc(S(=O)Cc4nncn4CCC)cc3)c2)cc1",
        "output": "225"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1ccccc1Br.CN(C)C=O.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3.O.O=C(O)[C@@H]1CCCN1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>Cc1ccc2c(c1)c1c(n2-c2ccccc2Br)CCN(C)C1",
        "output": "349"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCCn1cc(-c2ccc(C(F)(F)F)c(C(OC(C)(C)C)C(=O)OC)c2-c2ccc3c(c2)CCCO3)ccc1=O.O.[Li+].[OH-]>>CCCn1cc(-c2ccc(C(F)(F)F)c(C(OC(C)(C)C)C(=O)O)c2-c2ccc3c(c2)CCCO3)ccc1=O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.COc1ccccc1[C@H](C)C(=O)O.Cl.O=C1CCC(c2ccccc2)(c2ccccc2)[C@@H]2CNC[C@H]12.Oc1cccc2[nH]nnc12>>COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2C(=O)CCC(c3ccccc3)(c3ccccc3)[C@@H]2C1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1cc(C=O)c(O)c(C(C)(C)C)c1.Nc1ccccc1S.c1ccccc1>>CC(C)(C)c1cc(C=Nc2ccccc2S)c(O)c(C(C)(C)C)c1",
        "output": "329"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C(OC(C)(C)C)OC(C)(C)C.Cc1ccccc1.O=C(O)c1[nH]c2ccccc2c1Br.O=C(O)c1cc2ccccc2[nH]1>>CC(C)(C)OC(=O)c1[nH]c2ccccc2c1Br",
        "output": "768"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.C[C@@H]([NH2+]Cc1ccc(N(C)C)cc1)c1ccccc1.Cl.O=C([O-])[C@H](CC1CCOCC1)n1ncc2c(S(=O)(=O)C3CC3)cncc21>>O=C(O)[C@H](CC1CCOCC1)n1ncc2c(S(=O)(=O)C3CC3)cncc21",
        "output": "151"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C1N(C(c2ccccc2)c2ccccc2)c2cccc(F)c2C1(O)c1cc2c(cc1O)OCCO2.O=C1N(c2ccc(F)cc2)c2ccccc2C1(O)c1cc2c(cc1O)OCCO2>>O=C1C(c2cc3c(cc2O)OCCO3)c2ccccc2N1c1ccc(F)cc1",
        "output": "964"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1cc(N)cc(Br)c1.[K+]>>COc1cc(N)cc(B2OC(C)(C)C(C)(C)O2)c1",
        "output": "942"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Oc1ccc(C=O)cc1.CO.O.[BH4-].[Na+]>>CC(C)(C)[Si](C)(C)Oc1ccc(CO)cc1",
        "output": "356"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.COc1ccc(C2=CCN(C(=O)OC(C)(C)C)CC2)c2sc(NC(=O)c3ccnc(Cl)c3)nc12.O=C([O-])[O-].[Cs+].[Cs+]>>COc1ccc(C2=CCN(C(=O)OC(C)(C)C)CC2)c2sc(NC(=O)c3ccnc(N4CCOCC4)c3)nc12",
        "output": "220"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCOc1ccc(CCC(=O)Cl)cc1OC.C1CCOC1.CCN(CC)CC.Cl.NCc1ccc2c(c1)CCC2.O>>C#CCOc1ccc(CCC(=O)NCc2ccc3c(c2)CCC3)cc1OC",
        "output": "206"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(N)C(=O)Nc1cn(C(C)(C)CN2CCCC2)cn1.O=C(O)Cc1cc(F)cc(F)c1>>CC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(C(C)(C)CN2CCCC2)cn1",
        "output": "133"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCC(CCSc1ccc(OCC(=O)OCC)c(C)c1)c1sc2cc(C(F)(F)F)ccc2c1C.CO.[Na+].[OH-]>>CCCC(CCSc1ccc(OCC(=O)O)c(C)c1)c1sc2cc(C(F)(F)F)ccc2c1C",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrC(Br)(Br)Br.CC(C)(C)[Si](C)(C)OCc1cccc(CO)c1.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)[Si](C)(C)OCc1cccc(CBr)c1",
        "output": "750"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1ccccc1S.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)Nc1ccccc1S",
        "output": "473"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(=O)C(CCCN)(CCCCB1OC(C)(C)C(C)(C)O1)N(C)C(C)=O.Cl.ClCCl.O=Cc1ccc(Cl)c(Cl)c1.[Na+]>>CCOC(=O)C(CCCCB1OC(C)(C)C(C)(C)O1)(CCCNCc1ccc(Cl)c(Cl)c1)N(C)C(C)=O",
        "output": "468"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.CC(=O)O.COc1cc(-c2c(Cl)cc(Nc3n[nH]c(N)n3)cc2Cl)ccn1>>Nc1nc(Nc2cc(Cl)c(-c3cc[nH]c(=O)c3)c(Cl)c2)n[nH]1",
        "output": "758"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COC(=O)c1ccc(OC(C)C)c(C#N)c1.[Na+].[OH-]>>CC(C)Oc1ccc(C(=O)O)cc1C#N",
        "output": "222"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC1CCc2c1ncc(N)c2N1CCC[C@H](NC(=O)OC(C)(C)C)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CO.COc1ccc(F)c(-c2nc(C(=O)O)ccc2F)c1F.F[P-](F)(F)(F)(F)F>>COc1ccc(F)c(-c2nc(C(=O)Nc3cnc4c(c3N3CCC[C@H](NC(=O)OC(C)(C)C)C3)CCC4OC(C)=O)ccc2F)c1F",
        "output": "776"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1NCCc2ccc(C(F)(F)F)cc21.O=C(O)c1cc2ncc(Br)cn2n1>>CC1c2cc(C(F)(F)F)ccc2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "952"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C(CCCCCCCc1ccc2c(n1)NCCC2)c1cnc(OC)nc1.CO.Cl.[Na+].[OH-]>>COc1ncc(C(CCCCCCCc2ccc3c(n2)NCCC3)C(=O)O)cn1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cnn2c1N[C@@H](c1ccc(CC)cc1)C[C@H]2C(C)C.CCc1ccc([C@H]2C[C@@H](C(F)(F)F)n3ncc(C(=O)O)c3N2)cc1.[K+].[OH-]>>CCc1ccc([C@H]2C[C@@H](C(C)C)n3ncc(C(=O)O)c3N2)cc1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COC(=O)c1c(C)c(-c2cccnc2)n2c1CCCC2.O.[K+].[OH-]>>Cc1c(C(=O)O)c2n(c1-c1cccnc1)CCCC2",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC1CCN(Cc2ccccc2)CC1)c1ncccc1[N+](=O)[O-].O=[Pt]>>CCN(CC1CCN(Cc2ccccc2)CC1)c1ncccc1N",
        "output": "269"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.COC(=O)C1CNCCN1.Cl.Cl.O=C([O-])[O-].OC(c1ccc(CBr)cc1)(C(F)(F)F)C(F)(F)F.[K+].[K+]>>COC(=O)C1CN(Cc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)CCN1",
        "output": "248"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)=O.Cl.O=C([O-])O.OCCC1CCC2(CC1)OCCO2.[Na+]>>O=C1CCC(CCO)CC1",
        "output": "251"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.O=c1ccc2c([N+](=O)[O-])cccc2[nH]1.[Pd]>>Nc1cccc2[nH]c(=O)ccc12",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CC=C(c2ccc(-c3cnc4[nH]ccc4c3)cc2F)CC1.CCOC(C)=O.CO.[OH-].[OH-].[Pd+2]>>CC(C)(C)OC(=O)N1CCC(c2ccc(-c3cnc4[nH]ccc4c3)cc2F)CC1",
        "output": "806"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.COc1c(OC(F)F)ccc(-c2cccc3c2CCC3=O)c1O.CS(=O)(=O)c1ccc(CBr)cc1.O=C([O-])[O-].[K+].[K+]>>COc1c(OC(F)F)ccc(-c2cccc3c2CCC3=O)c1OCc1ccc(S(C)(=O)=O)cc1",
        "output": "127"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.COC(=O)CCCCCNc1ncnc2oc(-c3ccc(F)cc3)c(-c3ccc(OC)cc3)c12.Cl.[Na+].[OH-]>>COc1ccc(-c2c(-c3ccc(F)cc3)oc3ncnc(NCCCCCC(=O)O)c23)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(C(=O)O)cc1.CC1(C)[C@H](N)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>CC(C)(C)OC(=O)Nc1ccc(C(=O)N[C@H]2C(C)(C)[C@H](Oc3ccc(C#N)c(Cl)c3)C2(C)C)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)CCCNC(=O)Cc1ccc(C#N)cc1.N.[Ni]>>CN(C)CCCNC(=O)Cc1ccc(CN)cc1",
        "output": "175"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1cc(N)cc(Br)c1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[K+].[Pd]>>Cc1cc(N)cc(B2OC(C)(C)C(C)(C)O2)c1",
        "output": "942"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCc1c(C)nc(Cl)nc1Cl.Cc1nc(Cl)nc(Cl)c1C.Cc1nc(Cl)nc(NC2CCCCC2)c1C.Nc1ccc(F)cc1>>CCc1c(C)nc(Cl)nc1Nc1ccc(F)cc1",
        "output": "161"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(N2CCN(C)C[C@@H]2C)ncc1Br.C[C@@H](Oc1cc(B2OC(C)(C)C(C)(C)O2)cnc1N)c1c(Cl)ccc(F)c1Cl>>COc1cc(N2CCN(C)C[C@@H]2C)ncc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1",
        "output": "967"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.COc1c(C(C)C)cc(C(=O)c2c(Cc3ccccc3Br)oc(C)c2C)cc1C(C)C.ClCCl.ClCCl>>Cc1oc(Cc2ccccc2Br)c(C(=O)c2cc(C(C)C)c(O)c(C(C)C)c2)c1C",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CC(C)N1CCC(Oc2ccc3[nH]c(C(=O)O)cc3c2)CC1>>CC(C)N1CCC(Oc2ccc3[nH]c(C(=O)N4CCN(C(=O)OC(C)(C)C)CC4)cc3c2)CC1",
        "output": "605"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.ClCCl.NCCc1ccncc1.O=C(O)C1CCN(C(=O)c2cc3ccccc3n2Cc2ccc(Cl)cc2)CC1.On1nnc2ccccc21>>O=C(NCCc1ccncc1)C1CCN(C(=O)c2cc3ccccc3n2Cc2ccc(Cl)cc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCCCCCCBr.CCCC[N+](CCCC)(CCCC)CCCC.O.O=S(=O)([O-])O.OCCCc1ccccc1.[Na+].[OH-]>>BrCCCCCCOCCCc1ccccc1",
        "output": "95"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1ccccc1-c1nc2cccnc2s1.O.O=C(O)c1cc(O)cc(-c2ccccc2)n1>>O=C(Nc1ccccc1-c1nc2cccnc2s1)c1cc(O)cc(-c2ccccc2)n1",
        "output": "548"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.C1CCC2=NCCCN2CC1.CC#N.Cc1cc(O)cc(=O)o1>>Cc1cc(OCc2ccccc2)cc(=O)o1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CCN1CCNCC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccccc1-c1cn(S(=O)(=O)c2ccc(C)cc2)c2ncc(-c3cc(F)c(N)c(C(=O)O)c3)cc12.F[P-](F)(F)(F)(F)F>>CCN(CC)CCN1CCN(C(=O)c2cc(-c3cnc4c(c3)c(-c3ccccc3OC)cn4S(=O)(=O)c3ccc(C)cc3)cc(F)c2N)CC1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCC(COC)N1CCc2cc(N)c(OC)cc2CC1.O=S(=O)(c1ccccc1Nc1nc(Cl)ncc1Cl)N1CCCC1>>COCC(COC)N1CCc2cc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)N4CCCC4)n3)c(OC)cc2CC1",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccccc1[C@H]1CCNC[C@@H]1O.ClC(Cl)Cl.O=C([O-])O.[Na+]>>Cc1ccccc1[C@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1O",
        "output": "694"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#C.CC(O)C#Cc1cc(F)c2ncc(C(=O)NCc3ccc(Cl)cc3)c(O)c2c1.CO.ClCCl.[Pd]>>CC(O)CCc1cc(F)c2ncc(C(=O)NCc3ccc(Cl)cc3)c(O)c2c1",
        "output": "717"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=C[Si](C)(C)c1ccc(NC(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>C=C[Si](C)(C)c1ccc(N)cc1",
        "output": "782"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl.O=C(O)c1cnc(C(=O)c2cn(Cc3ccc(Cl)cc3)c3ccccc23)[nH]1>>O=C(c1ncc(C(=O)N2CCOCC2)[nH]1)c1cn(Cc2ccc(Cl)cc2)c2ccccc12",
        "output": "729"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)O.CN(C)c1ccc2c(n1)n(C1CCNCC1)c(=O)n2C.CS(=O)(=O)N1CCc2c(c(-c3ccc(C(F)(F)F)cc3)nn2C[C@@H](O)CCl)C1.O=C([O-])[O-].[K+].[K+]>>CN(C)c1ccc2c(n1)n(C1CCN(C[C@H](O)Cn3nc(-c4ccc(C(F)(F)F)cc4)c4c3CCN(S(C)(=O)=O)C4)CC1)c(=O)n2C",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(C)=O.Fc1cc(-c2nc(NCC3CCOCC3)ccc2Cl)c(Cl)cn1.N[C@H]1CC[C@H](N)CC1.O>>N[C@@H]1CC[C@@H](Nc2cc(-c3nc(NCC4CCOCC4)ccc3Cl)c(Cl)cn2)CC1",
        "output": "810"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.C=C(C)C(=O)O.CN(C)c1ccncc1.COC(=O)/C=C/c1ccc(OCCCCCCO)cc1>>C=C(C)C(=O)OCCCCCCOc1ccc(/C=C/C(=O)OC)cc1",
        "output": "174"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cl[Sn]Cl.O=[N+]([O-])c1ccc(Oc2cncc(Cl)c2)cc1>>Nc1ccc(Oc2cncc(Cl)c2)cc1",
        "output": "335"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCN(c2ccccc2O)CC1.CC(C)OC(=O)N=NC(=O)OC(C)C.OCCN1CCOCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCN(c2ccccc2OCCN2CCOCC2)CC1",
        "output": "478"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#CCCCOc1cccc(CN)c1F.CCN(CC)CC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cc1ccc(C(=O)O)c(N)n1.Cl.F[P-](F)(F)(F)(F)F.O.O=C([O-])O.[Na+]>>C#CCCCOc1cccc(CNC(=O)c2ccc(C)nc2N)c1F",
        "output": "790"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)c1ccc(C(=O)O)s1.Cl.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1>>CS(=O)(=O)c1ccc(C(=O)N[C@@H]2CC[C@@H](CCN3CCN(c4nccc5c4CCO5)CC3)CC2)s1",
        "output": "736"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1cc(C)n2c(C3=NOC(c4cc(Cl)cc(Cl)c4)(C(F)(F)F)C3)ccc(C(=O)O)c12.NCC(F)(F)F>>Cc1cc(C)n2c(C3=NOC(c4cc(Cl)cc(Cl)c4)(C(F)(F)F)C3)ccc(C(=O)NCC(F)(F)F)c12",
        "output": "674"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(-c2ccc(-c3cc(F)c(N)cc3C(F)(F)F)cc2)c[nH]1)C(C)C.ClCCl.O=C(Cl)c1ccc(F)nc1>>COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(-c2ccc(-c3cc(F)c(NC(=O)c4ccc(F)nc4)cc3C(F)(F)F)cc2)c[nH]1)C(C)C",
        "output": "642"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.ClCCl.FC(F)(F)Oc1ccc(/C=C/c2nc(COc3ccc(CSCCn4ccnn4)cc3)co2)cc1.O=C(OO)c1cccc(Cl)c1>>O=S(CCn1ccnn1)Cc1ccc(OCc2coc(/C=C/c3ccc(OC(F)(F)F)cc3)n2)cc1",
        "output": "13"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CSc1ncc([N+](=O)[O-])c(CCO)c1Cl.O.[Fe]>>CSc1ncc(N)c(CCO)c1Cl",
        "output": "269"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1ccc2oc(=O)n(C3CCNCC3)c2c1.O=C1c2ccccc2S(=O)(=O)N1CCCCBr>>CC(C)(C)c1ccc2oc(=O)n(C3CCN(CCCCN4C(=O)c5ccccc5S4(=O)=O)CC3)c2c1",
        "output": "73"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Clc1cccc(CBr)c1.Nc1cnc(-c2ccc(C3CCC3)c(O)c2F)cn1>>Nc1cnc(-c2ccc(C3CCC3)c(OCc3cccc(Cl)c3)c2F)cn1",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COc1nccc2c(-c3cc([N+](=O)[O-])ccc3Oc3ccc(Cl)cc3)cn(C)c12.O=[Pt]>>COc1nccc2c(-c3cc(N)ccc3Oc3ccc(Cl)cc3)cn(C)c12",
        "output": "335"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.Cl.ClC(Cl)(Cl)Cl.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-].c1ccc2c(c1)sc1ccccc12>>CC(=O)c1ccc2sc3ccccc3c2c1",
        "output": "31"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cl.Nc1cc(Oc2ccc(Cl)cc2Cl)c(Cl)cc1[N+](=O)[O-].[Zn]>>Nc1cc(Cl)c(Oc2ccc(Cl)cc2Cl)cc1N",
        "output": "335"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.CN(C=O)Cc1ccc([N+](=O)[O-])c(C(=O)O)c1.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cc(CN(C)C=O)ccc1[N+](=O)[O-]",
        "output": "415"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCNCC3)C2=O)c1.CCC(C)=O.O=C(CCCCl)c1ccccc1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CC(C)(C)OC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCN(CCCC(=O)c4ccccc4)CC3)C2=O)c1",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OCC(=O)N[C@@H](CC(C)C)C(=O)OC(C)(C)C.Cl.O>>COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OCC(=O)N[C@@H](CC(C)C)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)c1cc(C2CC2)cnc1Nc1cccc2c1ccn2CC1CC1.CO.[Na+].[OH-]>>O=C(O)c1cc(C2CC2)cnc1Nc1cccc2c1ccn2CC1CC1",
        "output": "569"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.COc1ccccc1COCCCOc1ccc([C@H]2CCN(C(=O)OC(C)(C)C)C[C@@H]2OCc2ccc3c(c2)N(CCN)CCC3)cc1.CS(=O)(=O)Cl.ClCCl>>COc1ccccc1COCCCOc1ccc([C@H]2CCN(C(=O)OC(C)(C)C)C[C@@H]2OCc2ccc3c(c2)N(CCNS(C)(=O)=O)CCC3)cc1",
        "output": "493"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1ccc(N)cc1-n1cnc2ccc(N3CCN(C)CC3)cc2c1=O.O.O=C(O)c1cccc2c1oc1ccccc12>>Cc1ccc(NC(=O)c2cccc3c2oc2ccccc23)cc1-n1cnc2ccc(N3CCN(C)CC3)cc2c1=O",
        "output": "799"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNC1.C1CCOC1.O=C(CCl)Nc1ccc(Br)cc1>>O=C(CN1CCCC1)Nc1ccc(Br)cc1",
        "output": "340"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1ccnc(Cl)c1F.ClCCl.O=C(O)C(F)(F)F>>Nc1ccnc(Cl)c1F",
        "output": "782"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CNc1ccncc1.Cl.O.On1nnc2ccccc21>>CN(C(=O)CNC(=O)OC(C)(C)C)c1ccncc1",
        "output": "315"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)c1cnc2c(cnn2CC)c1NC1CCCC1.O.[Na+].[OH-]>>CCn1ncc2c(NC3CCCC3)c(C(=O)O)cnc21",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.Nc1cccc(C(F)(F)F)c1.O.O=[N+]([O-])c1cnc2ccc(Br)cc2c1Cl.[Cl-].[Na+]>>O=[N+]([O-])c1cnc2ccc(Br)cc2c1Nc1cccc(C(F)(F)F)c1",
        "output": "115"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCC.Fc1ccc(CC2CCNCC2)cc1.O=C(O)c1cc2cc3[nH]c(=O)oc3cc2[nH]1>>O=C(c1cc2cc3[nH]c(=O)oc3cc2[nH]1)N1CCC(Cc2ccc(F)cc2)CC1",
        "output": "605"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCCCCCBr.CN(C)C=O.Cc1nc(-c2ccccc2)c(-c2ccccc2)[nH]1.[H-].[Na+]>>Cc1nc(-c2ccccc2)c(-c2ccccc2)n1CCCCCBr",
        "output": "276"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)O.CC(C)(C)[O-].CCN(C(C)C)C(C)C.CCOC(=O)Cc1c(Cl)nc(N)nc1Cl.COc1c(C)cnc(CN)c1C.Cl.Cl.[K+]>>CCOC(=O)Cc1c(Cl)nc(N)nc1NCc1ncc(C)c(OC)c1C",
        "output": "166"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.COC(=O)CCC(=O)Cl.ClCCl.NCCCc1cccc(OCc2ccccc2)c1>>COC(=O)CCC(=O)NCCCc1cccc(OCc2ccccc2)c1",
        "output": "45"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(O)(CN=[N+]=[N-])c1cc(Br)ncc1F.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(CN=[N+]=[N-])(OS(C)(=O)=O)c1cc(Br)ncc1F",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNCc1cccc([N+](=O)[O-])c1OCCOCCOCCO>>CN(Cc1cccc([N+](=O)[O-])c1OCCOCCOCCO)C(=O)OC(C)(C)C",
        "output": "867"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.Nc1cc([N+](=O)[O-])ccc1F.O.O=C(Cl)C1CC1.O=C([O-])O.[Na+]>>O=C(Nc1cc([N+](=O)[O-])ccc1F)C1CC1",
        "output": "9"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(C)=O.Ic1ccccc1.Nc1cc(O)ccc1Cl.O=C(O)c1ccccn1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>Nc1cc(Oc2ccccc2)ccc1Cl",
        "output": "382"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#Cc1cccc(C[C@H](N)C(=O)O)c1.O.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)OC(=O)N[C@@H](Cc1cccc(C#N)c1)C(=O)O",
        "output": "626"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCOC(=O)c1ccc(N2CCCC(OCc3c(-c4c(Cl)cccc4Cl)noc3C3CC3)CC2)cc1.[Li+].[OH-]>>O=C(O)c1ccc(N2CCCC(OCc3c(-c4c(Cl)cccc4Cl)noc3C3CC3)CC2)cc1",
        "output": "5"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc2c(Cl)nc(Nc3cc(C)[nH]n3)cc2c1OC.OB(O)c1ccccc1F>>COc1ccc2c(-c3ccccc3F)nc(Nc3cc(C)[nH]n3)cc2c1OC",
        "output": "865"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCN(CC)CC.Cl.Cl.NCCc1c[nH]cn1.O.O=C(O)c1ccc2c(Cl)cc(Cl)c(O)c2n1.On1nnc2ccccc21>>O=C(NCCc1c[nH]cn1)c1ccc2c(Cl)cc(Cl)c(O)c2n1",
        "output": "137"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCS(=O)(=O)Nc1ccc(Cl)c(N)c1Cl.ClC(Cl)Cl.O=C(Cl)c1cccc2c(Cl)ncnc12.c1ccncc1>>CCCS(=O)(=O)Nc1ccc(Cl)c(NC(=O)c2cccc3c(Cl)ncnc23)c1Cl",
        "output": "642"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)C1=C(C2CCCCO2)CS[C@@H]2[C@H](N)C(=O)N12.CCN(C(C)C)C(C)C.CN(C)C=O.CO/N=C(\\C(=O)O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1.CS(=O)(=O)Cl.Cl.c1ccncc1>>CO/N=C(\\C(=O)N[C@@H]1C(=O)N2C(C(=O)OC(C)(C)C)=C(C3CCCCO3)CS[C@H]12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1",
        "output": "587"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)N1CCC(c2ccc([N+](=O)[O-])cc2)CC1.CCO.NN.[Pd]>>CC(C)N1CCC(c2ccc(N)cc2)CC1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(=O)(=O)Cl.N#CCOc1ccc(OCc2ccccc2)c(N)c1.O.c1ccncc1>>CS(=O)(=O)Nc1cc(OCC#N)ccc1OCc1ccccc1",
        "output": "194"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.CC1(C)CC(Nc2nc(Cl)ncc2F)CC(C)(C)N1.Cc1ccc(S(=O)(=O)O)cc1.Nc1cc(C2CC2)cc(-n2cnnn2)c1>>CC1(C)CC(Nc2nc(Nc3cc(C4CC4)cc(-n4cnnn4)c3)ncc2F)CC(C)(C)N1",
        "output": "808"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COc1ccc(CS(=O)(=O)c2cc(OC)c(OC)c(OC)c2)cc1[N+](=O)[O-].Cl[Sn]Cl.O.O>>COc1ccc(CS(=O)(=O)c2cc(OC)c(OC)c(OC)c2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)n1cnc2cc(Br)ccc21.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.[K+]>>CC(C)n1cnc2cc(B3OC(C)(C)C(C)(C)O3)ccc21",
        "output": "934"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C1COCCO1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc(C2CCCCO2)c2sc(N)nc12.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(F)cc1>>COc1ccc(C2CCCCO2)c2sc(NC(=O)c3ccc(F)cc3)nc12",
        "output": "918"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1c(Br)cc(C(=O)N2CCOc3ncc(-c4ccccc4)cc32)cc1Br.ClCCl.O>>O=C(c1cc(Br)c(O)c(Br)c1)N1CCOc2ncc(-c3ccccc3)cc21",
        "output": "786"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCC(C#N)(CC)c1cccc(N)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCC(CC)(CN)c1cccc(N)c1",
        "output": "246"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.Cl.O=C(O)c1ccc(NCCOc2cccc3ccccc23)cc1.c1ccncc1>>CC(=O)N(CCOc1cccc2ccccc12)c1ccc(C(=O)O)cc1",
        "output": "160"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.Cc1noc2c1-c1ccc(-c3cnn(C)c3)cc1N(c1ccc(C#N)cc1)CC2CC(N)=O.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C([O-])O.[Na+]>>Cc1noc2c1-c1ccc(-c3cnn(C)c3)cc1N(c1ccc(C#N)cc1)CC2CC#N",
        "output": "172"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.Cn1ncc(NCCCl)c(Cl)c1=O.Fc1ccc2c(C3CCNCC3)noc2c1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>Cn1ncc(NCCN2CCC(c3noc4cc(F)ccc34)CC2)c(Cl)c1=O",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)N.CCN(CC)CC.CCN=C=NCCCN(C)C.ClCCl.Cn1nc(-c2cnc3[nH]cc(C(=O)O)c3n2)c2cc(C(F)(F)F)ccc21.O.On1nnc2ccccc21>>Cn1nc(-c2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c2cc(C(F)(F)F)ccc21",
        "output": "737"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].COCCOC.Cc1ccccc1B(O)O.Nc1ccccc1Br.O=C([O-])[O-].[K+].[K+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1ccccc1-c1ccccc1N",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)C(Nc1ccc(F)cc1)C(=O)O.OCc1[nH]ccc1Cc1ccccc1>>CC(C)C(Nc1ccc(F)cc1)C(=O)OCc1[nH]ccc1Cc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N#CCC(=O)O.O.O=C(Nc1nc2ccccc2n1CC1CNC1)c1ccc(-c2cn[nH]c2)s1>>N#CCC(=O)N1CC(Cn2c(NC(=O)c3ccc(-c4cn[nH]c4)s3)nc3ccccc32)C1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.Cc1cnc(Cl)nc1N(C)C1CCN(c2ccc(C#N)cn2)CC1.Cl.Cn1cc(N)cn1>>Cc1cnc(Nc2cnn(C)c2)nc1N(C)C1CCN(c2ccc(C#N)cn2)CC1",
        "output": "992"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCNc1cccnc1N(CC)CC1CCNCC1.O=C(O)c1ccc[nH]1>>CCNc1cccnc1N(CC)CC1CCN(C(=O)c2ccc[nH]2)CC1",
        "output": "605"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN1CCNCC1.COc1ccc(C2(C(=O)O)CCOCC2)cc1.F[B-](F)(F)F>>COc1ccc(C2(C(=O)N3CCN(C)CC3)CCOCC2)cc1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.COC(=O)Cl.Nc1ccccc1.O.[Na+].[OH-]>>COC(=O)Nc1ccccc1",
        "output": "102"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.Cc1cccc(Nc2ncnc3cnc(S(C)(=O)=O)nc23)c1.Cc1cccc(Nc2ncnc3cnc(S(C)=O)nc23)c1.NC1CCCCC1>>Cc1cccc(Nc2ncnc3cnc(NC4CCCCC4)nc23)c1",
        "output": "666"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)[C@@H]1CCCN(CCOCC=C(c2ccccc2)c2cccc(Cl)c2)C1.[Na+].[OH-]>>O=C(O)[C@@H]1CCCN(CCOCC=C(c2ccccc2)c2cccc(Cl)c2)C1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)Cc1cccc(Br)n1.CS(C)=O.Cl.O=C(O)[C@@H]1CCCN1.O=C([O-])[O-].OC1CNC1.[Cs+].[Cs+].[Cu]I>>COC(=O)Cc1cccc(N2CC(O)C2)n1",
        "output": "647"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)CC(=O)CC(C)C.NNc1cc(O)ncn1>>CC(C)CC(CC(C)C)=NNc1cc(O)ncn1",
        "output": "285"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)NC(=O)Nc1ccc(OS(=O)(=O)c2cccc(C(F)(F)F)c2)cc1[N+](=O)[O-].CO.COCCO.[H][H].[Ni]>>CC(=O)NC(=O)Nc1ccc(OS(=O)(=O)c2cccc(C(F)(F)F)c2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "NC(=O)C(O)C(N)Cc1ccccc1.O=C(O)c1cccnc1-c1csc(-c2ccc(F)cc2)n1>>NC(=O)C(O)C(Cc1ccccc1)NC(=O)c1cccnc1-c1csc(-c2ccc(F)cc2)n1",
        "output": "674"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)c1ccc(-c2c([N+](=O)[O-])ccc3c2/C(=C/c2[nH]ccc2OC)C(=O)N3)cc1.O.[Cl-].[NH4+].[Zn]>>COC(=O)c1ccc(-c2c(N)ccc3c2/C(=C/c2[nH]ccc2OC)C(=O)N3)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O.O=[N+]([O-])c1cc(Br)ccc1F.[Cl-].[Fe].[NH4+]>>Nc1cc(Br)ccc1F",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1=COCCC1.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.OCCCCCCCCCBr.c1cc[nH+]cc1>>BrCCCCCCCCCOC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cc1ccc(C2=CC(=O)CC2)cc1.[BH4-].[Na+]>>Cc1ccc(C2=CC(O)CC2)cc1",
        "output": "288"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNC1.C1CCOC1.CCN(CC)CC.O.O=[N+]([O-])c1cccc(CBr)c1>>O=[N+]([O-])c1cccc(CN2CCCC2)c1",
        "output": "248"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "B.C1CCOC1.C1CCOC1.CC(C)(C#N)c1ccc([N+](=O)[O-])cc1Cl>>CC(C)(CN)c1ccc([N+](=O)[O-])cc1Cl",
        "output": "246"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCCc1nc(C)[nH]c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCN(CC)CC.CCOC(C)=O.CCOc1ccc(B(O)O)cc1.ClCCl.[Cu+2].c1ccncc1>>CCCc1nc(C)n(-c2ccc(OCC)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "962"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.Fc1cccc2[nH]ccc12.O=P(Cl)(Cl)Cl>>O=Cc1c[nH]c2cccc(F)c12",
        "output": "266"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(Nc2cnc(Oc3ccc(Oc4ccccc4)cc3)c(C(N)=O)c2)CC1.Cl.ClCCl>>NC(=O)c1cc(NC2CCNCC2)cnc1Oc1ccc(Oc2ccccc2)cc1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)CC=C(c2nccs2)c2cc(C#Cc3ccc(C(=O)O)cc3)ccc21.CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(c2ccccc2)=CCC3(C)C)cc1>>CC1(C)CC=C(c2ccccc2)c2cc(C#Cc3ccc(C(=O)O)cc3)ccc21",
        "output": "5"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CCOc1cc(N2CCN(CCS(C)(=O)=O)CC2)ccc1[N+](=O)[O-]>>CCOc1cc(N2CCN(CCS(C)(=O)=O)CC2)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CO.COc1cc2[nH]c(=O)c3c(N)n(-c4cc(OCc5ccccc5)ccc4C)nc3c2cc1OC.[H][H].[Pd]>>COc1cc2[nH]c(=O)c3c(N)n(-c4cc(O)ccc4C)nc3c2cc1OC",
        "output": "23"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CN(C)C(=O)c1ccc(S(=O)(=O)c2ccc(NC(=O)[C@@](C)(O)C(F)(F)F)c(Cl)c2[N+](=O)[O-])cc1.Cl.O.O=C([O-])O.[Fe].[Na+]>>CN(C)C(=O)c1ccc(S(=O)(=O)c2ccc(NC(=O)[C@@](C)(O)C(F)(F)F)c(Cl)c2N)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(Cc1ccc(-c2ccc(S(C)(=O)=O)cc2)nc1)C1CCNCC1.O=C(Cl)Oc1ccccc1>>CN(Cc1ccc(-c2ccc(S(C)(=O)=O)cc2)nc1)C1CCN(C(=O)Oc2ccccc2)CC1",
        "output": "219"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COc1ccccc1N1CCNCC1.NC(=O)Cc1ccccc1OCC1CO1>>COc1ccccc1N1CCN(CC(O)COc2ccccc2CC(N)=O)CC1",
        "output": "76"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)/C=C/C(=O)c1nn(-c2ccccc2)ccc1=O.NNc1ccc(Cl)c2ccccc12>>O=c1ccn(-c2ccccc2)nc1-c1ccnn1-c1ccc(Cl)c2ccccc12",
        "output": "984"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCI.CN(C)C=O.O=C([O-])[O-].Oc1cc(O)cc(O)c1.[K+].[K+]>>CCOc1cc(O)cc(O)c1",
        "output": "198"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCOc2nc(Cl)ccc2C1.CC(O)C(C)(C)C.Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[H-].[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(Oc1ccc2c(n1)OCCN(C(=O)OC(C)(C)C)C2)C(C)(C)C",
        "output": "433"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(CCn1cc(-c2oc(C)nc2C)c(=O)[nH]c1=O)OC>>Cc1nc(C)c(-c2cn(CCC=O)c(=O)[nH]c2=O)o1",
        "output": "234"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1ncc2c(N3CCNCC3)cccc2n1.ClCCl.O=CCc1c(F)ccc(Br)c1O.O=S(=O)([O-])[O-].[Cl-].[NH4+].[Na+].[Na+].[Na+]>>Cc1ncc2c(N3CCN(CCc4c(F)ccc(Br)c4O)CC3)cccc2n1",
        "output": "484"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cc1c(CN(C(=O)OC(C)(C)C)c2ccc(C#N)cc2)cnc(CO)c1OCc1cccc(C#N)c1.[Mn+4].[O-2].[O-2]>>Cc1c(CN(C(=O)OC(C)(C)C)c2ccc(C#N)cc2)cnc(C=O)c1OCc1cccc(C#N)c1",
        "output": "263"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.O=[N+]([O-])c1ccc(F)cc1O[C@@H]1CC[C@@H](O)CC1.[H][H].[Pd]>>Nc1ccc(F)cc1O[C@@H]1CC[C@@H](O)CC1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CON.Cc1c(C)c2c(c(C)c1O)C(=O)CC1(CCC1)S2.Cl.c1ccncc1>>CON=C1CC2(CCC2)Sc2c(C)c(C)c(O)c(C)c21",
        "output": "212"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC1CO1.CCOCC.Fc1ccc2[nH]ccc2c1.O.[H-].[Na+]>>CC(O)Cn1ccc2cc(F)ccc21",
        "output": "749"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCC2=NCCCN2CC1.CCOC(=O)Nc1n[nH]c2ccccc12.CS(C)=O.Clc1ccc(N2CCNCC2)cc1Cl>>O=C(Nc1n[nH]c2ccccc12)N1CCN(c2ccc(Cl)c(Cl)c2)CC1",
        "output": "613"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(O)CNC(=O)c1nc(C(=O)O)c(-c2ccc(C(O)(C(F)(F)F)C(F)(F)F)c3ccccc23)s1.CC1CCNCC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O>>CC1CCN(C(=O)c2nc(C(=O)NCC(C)(C)O)sc2-c2ccc(C(O)(C(F)(F)F)C(F)(F)F)c3ccccc23)CC1",
        "output": "747"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C#N)c1cccc(Cl)c1.CCO.[BH4-].[Na+].[Ni]>>CC(CN)c1cccc(Cl)c1",
        "output": "246"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1ccns1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CNC1.O=C1CCC(O)(c2ccns2)CC1.O=C1CCC2(CC1)OCCO2.[Na+]>>O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CN(C2CCC(O)(c3ccns3)CC2)C1",
        "output": "187"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Oc1ccc(CC(=O)Cl)cc1.CCCN.CCOCC.O>>CCCNC(=O)Cc1ccc(OC(C)=O)cc1",
        "output": "45"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COc1ccc(S(=O)(=O)Cl)cc1.[NH4+].[OH-]>>COc1ccc(S(N)(=O)=O)cc1",
        "output": "245"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CCN1CCC(=O)CC1.CO.Nc1ccc2[nH]ncc2c1.O=C([O-])O.[Na+]>>CCN1CCC(Nc2ccc3[nH]ncc3c2)CC1",
        "output": "469"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.NCCc1ccc(Cl)cc1.Nc1nc(Cl)cc(-c2cccc(Cl)c2Cl)n1>>Nc1nc(NCCc2ccc(Cl)cc2)cc(-c2cccc(Cl)c2Cl)n1",
        "output": "110"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(N)(CO)CO.Cc1cc(F)ccc1-c1nc(S(C)(=O)=O)nc2c1ccc(=O)n2-c1ccccc1F>>Cc1cc(F)ccc1-c1nc(NC(C)(CO)CO)nc2c1ccc(=O)n2-c1ccccc1F",
        "output": "629"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.Cl.N[C@H]1CN2CCC1CC2.O=C(O)/C=C/c1cccc(Br)c1>>O=C(/C=C/c1cccc(Br)c1)N[C@H]1CN2CCC1CC2",
        "output": "767"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC(C)C(N)C(O)C(F)(F)F.CC(C)COC(=O)Cl.CN(C)C=O.CN1CCOCC1.C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O.Cl>>CC(C)C(NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C(O)C(F)(F)F",
        "output": "216"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCC2=NCCCN2CC1.COCCOC.N#Cc1c(Cl)nc(N)nc1-c1ccccc1.OC1CCCCC1>>N#Cc1c(OC2CCCCC2)nc(N)nc1-c1ccccc1",
        "output": "653"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.Cl.Fc1cc2nc(-c3ccc(Cl)cc3)n(C(CBr)C3CCCCC3)c2cc1F.Oc1cccnc1.[H-].[Na+]>>Fc1cc2nc(-c3ccc(Cl)cc3)n(C(COc3cccnc3)C3CCCCC3)c2cc1F",
        "output": "608"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCI.O=C(O)c1ccc(Cl)c(Br)c1.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)c1ccc(Cl)c(Br)c1",
        "output": "196"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Clc1ncnc2cnccc12.Nc1ccc2[nH]ccc2c1>>c1cc2c(Nc3ccc4[nH]ccc4c3)ncnc2cn1",
        "output": "161"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)N.CC1(C)CCc2c(cccc2OCC(O)CCl)CC1=O.CCOCC.O=C(O)C(O)C(O)C(=O)O>>CC(C)(C)NCC(O)COc1cccc2c1CCC(C)(C)C(=O)C2",
        "output": "279"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1cc2c(=O)n(COC(=O)C(C)(C)C)cnc2cc1O.Cc1ccc(S(=O)(=O)OCCC2CCN(C(=O)OC(C)(C)C)CC2)cc1.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(=O)n(COC(=O)C(C)(C)C)cnc2cc1OCCC1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "438"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1noc(-c2c(N)ncnc2Cl)n1.CCCCO.CCN(C(C)C)C(C)C.CCOC(C)=O.C[C@H](N)c1nc2cccc(Cl)c2c(=O)n1C1CC1>>CC(C)c1noc(-c2c(N)ncnc2N[C@@H](C)c2nc3cccc(Cl)c3c(=O)n2C2CC2)n1",
        "output": "166"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1nc(OC)cc(OC)c1OCc1ccccc1.Cl.[Na+].[OH-]>>COc1cc(OC)c(OCc2ccccc2)c(C(=O)O)n1",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N(CCc1ccc([N+](=O)[O-])cc1)C1CC1.CO.[Pd]>>CC(C)(C)OC(=O)N(CCc1ccc(N)cc1)C1CC1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CN(C)C=O.N#Cc1cccnc1N1CCNCC1.O=C(O)Cc1ccc(Oc2ccccc2)cc1.O=C(n1ccnc1)n1ccnc1>>N#Cc1cccnc1N1CCN(C(=O)Cc2ccc(Oc3ccccc3)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)OC(=O)NCCCc1ccccc1CO.CCOCC.ClCCl>>CC(C)(C)OC(=O)NCCCc1ccccc1C=O",
        "output": "179"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.Fc1ccc2[nH]nc(I)c2c1>>Fc1ccc2c(c1)c(I)nn2Cc1ccccc1",
        "output": "635"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.Cl.NCc1ccc(C(F)(F)F)cc1.O=C(Cl)c1c(Cl)cccc1Cl>>O=C(NCc1ccc(C(F)(F)F)cc1)c1c(Cl)cccc1Cl",
        "output": "411"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)C(F)=Cc1ccc(-c2ncccn2)cc1.ClCCl.[H-]>>OCC(F)=Cc1ccc(-c2ncccn2)cc1",
        "output": "150"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC1CCCCC1O.CN(C)C=O.N#Cc1ccc(F)cc1Cl.O>>CCC1CCCCC1Oc1ccc(C#N)c(Cl)c1",
        "output": "485"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#CCNC(=O)c1cccc(F)c1Nc1nc(Cl)ncc1Cl.COCCOC(=O)N1CCCOc2cc(N)ccc21>>C#CCNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)OCCCN3C(=O)OCCOC)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCCOc1cc(I)ccc1CO.CCN(CC)CC.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl>>CCCCCCCOc1cc(I)ccc1C=O",
        "output": "179"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)c1cc(COC(=O)NC2CC3(CNC3)C2)on1.CO.ClCCl.Fc1ccc2nc(Cl)ccc2c1.O=C(O)C(F)(F)F>>CCOC(=O)c1cc(COC(=O)NC2CC3(C2)CN(c2ccc4cc(F)ccc4n2)C3)on1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C[NH3+])CCCO.CCN(CC)CC.ClCCl.[Cl-]>>CC(C)(CCCO)CNC(=O)OC(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN1CCOCC1.CNOC.Cc1cc(Br)ccc1C(=O)O.Cl.ClCCl.On1nnc2ccccc21>>CON(C)C(=O)c1ccc(Br)cc1C",
        "output": "828"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCC(=O)[C@H]1CCN(C(=O)OC(C)(C)C)C1.CO.[BH4-].[Na+]>>CCCC(O)[C@H]1CCN(C(=O)OC(C)(C)C)C1",
        "output": "91"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCCC.CCO.CCO.CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2oc3ccc(F)cc3c2C)C2CCCC2)cc1.[Na+].[OH-]>>Cc1c(C(Nc2ccc(C(=O)N(C)CCC(=O)O)cc2)C2CCCC2)oc2ccc(F)cc12",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOc1cc(C(=O)OC)cc(C(F)(F)F)c1-c1ccc(F)cc1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CCOc1cc(CO)cc(C(F)(F)F)c1-c1ccc(F)cc1",
        "output": "444"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.ClCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1.N#CCCc1cccc2cc[nH]c12.[Cl-].[H-].[NH4+].[Na+]>>N#CCCc1cccc2ccn(Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c12",
        "output": "556"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC(Oc2ccc(F)cc2OCc2ccccc2)CC1.[C].[Pd]>>CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC(Oc2ccc(F)cc2O)CC1",
        "output": "23"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(=O)/C=C/c1ccc(NC2CCNCC2)nc1.CCOC(C)=O.CN(C)C=O.Cl.Cl.Cl.O.O=C(O)c1ccc(-n2cccc2)cc1.On1nnc2ccccc21>>CCOC(=O)/C=C/c1ccc(NC2CCN(C(=O)c3ccc(-n4cccc4)cc3)CC2)nc1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)N=S(C)(=O)c1ccc(N)cc1Br.CC[C@H](CO)Nc1nc(Cl)ncc1-c1ccsc1>>CCOC(=O)N=S(C)(=O)c1ccc(Nc2ncc(-c3ccsc3)c(N[C@H](CC)CO)n2)cc1Br",
        "output": "808"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)[C@H](C=C=CCl)[C@H]1C(=O)O.OCc1cccc(Oc2ccccc2)c1>>CC1(C)[C@H](C=C=CCl)[C@H]1C(=O)OCc1cccc(Oc2ccccc2)c1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.N#Cc1ccc(NCCCCF)c([N+](=O)[O-])c1.[Pd]>>N#Cc1ccc(NCCCCF)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1cc2ccc(OCc3ccccc3)cc2o1.[Pd]>>COC(=O)c1cc2ccc(O)cc2o1",
        "output": "23"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)ccc(C=O)c3F)n2)C[C@@H](NC(=O)OC(C)(C)C)C1.[BH4-].[Na+]>>C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)ccc(CO)c3F)n2)C[C@@H](NC(=O)OC(C)(C)C)C1",
        "output": "356"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.Fc1ccc(-c2ccc3cc[nH]c3c2)cc1>>CC(C)(C)OC(=O)n1ccc2ccc(-c3ccc(F)cc3)cc21",
        "output": "748"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CNC(=O)c1c(-c2ccc(F)cc2)oc2ncc(-c3cccc(C(=O)OC)c3)cc12.CO.[Na+].[OH-]>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ncc(-c3cccc(C(=O)O)c3)cc12",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccccc1.FC(F)(F)c1nnc2ccc(Br)cn12.O=C([O-])[O-].OB(O)c1ccc(C2CC2)cc1.[K+].[K+]>>FC(F)(F)c1nnc2ccc(-c3ccc(C4CC4)cc3)cn12",
        "output": "833"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)c1csc(-c2cc3cc(CCCCl)ccc3o2)n1.Cc1ccc2c(C#N)c[nH]c2c1.[Cl-].[Na+].[OH-]>>Cc1ccc2c(C#N)cn(CCCc3ccc4oc(-c5nc(C(C)(C)C)cs5)cc4c3)c2c1",
        "output": "42"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)O.CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.CCN1CCCOc2cc(N)ccc21.CNC(=O)c1cccc(F)c1Nc1nc(Cl)ncc1Cl>>CCN1CCCOc2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc21",
        "output": "808"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)c1c(-c2ccccc2OC)ccc2c1NC(=O)C(C)(C)N2.Cl.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1ccccc1-c1ccc2c(c1CO)NC(=O)C(C)(C)N2",
        "output": "444"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNCC1.CC#N.N#Cc1ccc(C(F)(F)F)cc1F>>N#Cc1ccc(C(F)(F)F)cc1N1CCCCC1",
        "output": "26"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)N=C=O.CCC1(c2cccc(OC)c2)CCCCN(CCN)C1=O.CCN(CC)CC.CN(C)C=O.Cl>>CCC1(c2cccc(OC)c2)CCCCN(CCNC(=O)NC(C)(C)C)C1=O",
        "output": "244"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)Cn1c(C)c(Cc2ccc(=O)n(Cc3ccccc3)n2)c2ccccc21.Cl.O.[Li+].[OH-]>>Cc1c(Cc2ccc(=O)n(Cc3ccccc3)n2)c2ccccc2n1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCc1cc(C(F)(F)F)ccc1Br.O=C1CCCCC1.[Li]CCCC>>CC(C)(C)[Si](C)(C)OCc1cc(C(F)(F)F)ccc1C1(O)CCCCC1",
        "output": "321"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(S(=O)(=O)NC(CCOCc2ccccc2)C2CCN(C(=O)OC(C)(C)C)CC2)c2ccccc12.O=C(O)C(F)(F)F>>Cc1ccc(S(=O)(=O)NC(CCOCc2ccccc2)C2CCNCC2)c2ccccc12",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c([N+](=O)[O-])c1.O.[Cl-].[Fe].[NH4+]>>CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NC1CCN(c2ncnc3[nH]ncc23)CC1.CCOCC.Cl>>NC1CCN(c2ncnc3[nH]ncc23)CC1",
        "output": "538"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.O.O=Cc1ccc(/C(=C\\C=C\\C(=O)Nc2cccc3cnccc23)c2ccc(C(F)(F)F)cc2)cc1.[Na+]>>O=C(/C=C/C=C(\\c1ccc(CN2CCCC2)cc1)c1ccc(C(F)(F)F)cc1)Nc1cccc2cnccc12",
        "output": "567"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCC(CC)N[C@H]1COc2c(F)ccc(OC)c2C1.CCC=O.CO.[BH3-]C#N.[Na+]>>CCCN(C(CC)CC)[C@H]1COc2c(F)ccc(OC)c2C1",
        "output": "484"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.COCCN.Cc1cc(Cl)c([N+](=O)[O-])c(Cl)n1>>COCCNc1cc(C)nc(Cl)c1[N+](=O)[O-]",
        "output": "78"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)NC[C@H]1CN(S(=O)(=O)c2cccc(C)c2)c2cc(N)cnc2O1.CCN(C(C)C)C(C)C.O=C(Cl)c1c(F)cccc1Cl>>CC(=O)NC[C@H]1CN(S(=O)(=O)c2cccc(C)c2)c2cc(NC(=O)c3c(F)cccc3Cl)cnc2O1",
        "output": "501"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CNC.COCCC(=O)NC(C)(C)CC(C)=O.C[NH2+]C.O=C([O-])O.O=[Pt].[H][H].[Na+].[O-][Cl+3]([O-])([O-])[O-]>>COCCC(=O)NC(C)(C)CC(C)N(C)C",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.OC1CC=C(COCc2ccccc2)C1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OC1CC=C(COCc2ccccc2)C1",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.COc1c(NN)ncnc1N1CCC(c2ccc(F)cc2)CC1.ClCCl.O.O=C(O)CC1CC1.O=C([O-])O.O=S(Cl)Cl.[Na+]>>COc1c(NNC(=O)CC2CC2)ncnc1N1CCC(c2ccc(F)cc2)CC1",
        "output": "459"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1cc(C)cc([N+](=O)[O-])c1O.CCO.Cl.O.O=Cc1ccc(OCc2ccccc2)c([N+](=O)[O-])c1.[Na+].[OH-]>>Cc1cc(C(=O)/C=C/c2ccc(OCc3ccccc3)c([N+](=O)[O-])c2)c(O)c([N+](=O)[O-])c1",
        "output": "656"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)CC(C(=O)O)N1C(=O)Cc2cc(Br)ccc21.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cn1ccc(N)n1.F[P-](F)(F)(F)(F)F>>CC(C)CC(C(=O)Nc1ccn(C)n1)N1C(=O)Cc2cc(Br)ccc21",
        "output": "795"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(C)O.N#Cc1ccc(N)cc1.Nc1cc(Cl)nc(Cl)n1>>N#Cc1ccc(Nc2nc(N)cc(Cl)n2)cc1",
        "output": "808"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1CCCC1=O.COc1ccc2ccc(-c3ccc4ccccc4c3)cc2c1.Cl.O.c1ccncc1>>Oc1ccc2ccc(-c3ccc4ccccc4c3)cc2c1",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CS(C)=O.C[C@H](NC(=O)OC(C)(C)C)[C@@H]1CCNC1.O.O=c1[nH]c(=O)n(C2CC2)c2c(C(F)F)c(F)c(F)cc12>>C[C@H](NC(=O)OC(C)(C)C)[C@@H]1CCN(c2c(F)cc3c(=O)[nH]c(=O)n(C4CC4)c3c2C(F)F)C1",
        "output": "676"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=O.Cc1ccc(NC(=O)c2ccc(N(C)C3CCNC3)cc2)cc1Nc1nccc(-c2cccnc2)n1>>Cc1ccc(NC(=O)c2ccc(N(C)C3CCN(C)C3)cc2)cc1Nc1nccc(-c2cccnc2)n1",
        "output": "217"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.Cc1ccccc1.N#CCCCBr>>N#CCCCN1CCCCC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.Clc1ccnc2ccccc12.O=S(=O)(O)O.O=[N+]([O-])O.[NH4+].[OH-]>>O=[N+]([O-])c1cccc2c(Cl)ccnc12",
        "output": "328"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.COC(=O)c1cc(C(C)=O)c(C(F)(F)F)cc1NC(C)=O.COC(OC)N(C)C>>COC(=O)c1cc(C(=O)/C=C/N(C)C)c(C(F)(F)F)cc1NC(C)=O",
        "output": "898"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl.O=[N+]([O-])c1cc(Cl)c(CO)c(Cl)c1>>O=Cc1c(Cl)cc([N+](=O)[O-])cc1Cl",
        "output": "179"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)c1cc(Cl)c2cccnc2c1N1CCNCC1.CCN(CC)CC.CN(C)C(=O)Cl.ClCCl>>CC(=O)c1cc(Cl)c2cccnc2c1N1CCN(C(=O)N(C)C)CC1",
        "output": "258"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.COC(=O)N1c2ccc(-c3csc(C4(O)CCN(C(=O)OC(C)(C)C)CC4)n3)c(OC3CCC3)c2CC[C@@H]1C.Cl>>COC(=O)N1c2ccc(-c3csc(C4(O)CCNCC4)n3)c(OC3CCC3)c2CC[C@@H]1C",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CS(=O)(=O)c1ccc(OCC2CC2)c(Br)c1.Cl[Pd]Cl.Cn1cc(B2OC(C)(C)C(C)(C)O2)c2ccccc2c1=O.O.O=P([O-])([O-])[O-].[Fe+2].[K+].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cn1cc(-c2cc(S(C)(=O)=O)ccc2OCC2CC2)c2ccccc2c1=O",
        "output": "954"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COc1cc2c(cc1C(=O)C1CCNCC1)c(C(=O)C(=O)N(C)C)cn2C.Fc1ccc(CBr)cc1>>COc1cc2c(cc1C(=O)C1CCN(Cc3ccc(F)cc3)CC1)c(C(=O)C(=O)N(C)C)cn2C",
        "output": "248"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCS(=O)(=O)Cl.ClCCl.N[C@@H]1CCOC[C@H]1c1ccc(-c2ccccc2)cc1>>CCS(=O)(=O)N[C@@H]1CCOC[C@H]1c1ccc(-c2ccccc2)cc1",
        "output": "493"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1ccc(F)c(OC)c1F.ClCCl>>Oc1ccc(F)c(O)c1F",
        "output": "20"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.CCCOc1ccccc1-c1nc(N)cc(=O)[nH]1>>CCCOc1ccccc1-c1nc(NC(C)=O)cc(=O)[nH]1",
        "output": "394"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.CCOC(=O)C1(N)Cc2ccccc2C1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cc1cccc(C(=O)O)c1I.ClCCl.ClCCl.F[P-](F)(F)(F)(F)F>>CCOC(=O)C1(NC(=O)c2cccc(C)c2I)Cc2ccccc2C1",
        "output": "709"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(C(=O)c2c(Cc3ccc(Br)cc3)sc(C)c2C)cc1C1CCCC1.Cc1ccsc1C.ClCCl>>Cc1sc(Cc2ccc(Br)cc2)c(C(=O)c2ccc(O)c(C3CCCC3)c2)c1C",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cl.Cl.O.O=C(O)C1CNC1.O=c1c(-n2ccnc2)c[nH]n1-c1cc(Cl)ncn1.[Na+].[OH-]>>O=C(O)C1CN(c2cc(-n3[nH]cc(-n4ccnc4)c3=O)ncn2)C1",
        "output": "162"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.Cl.ClCCl.Nc1ccc(F)cc1.O=C(O)c1cccc(N2CCN(c3ncnc4ccc(-c5ccn(C(c6ccccc6)(c6ccccc6)c6ccccc6)n5)cc34)CC2)c1.On1nnc2ccccc21>>O=C(Nc1ccc(F)cc1)c1cccc(N2CCN(c3ncnc4ccc(-c5ccn(C(c6ccccc6)(c6ccccc6)c6ccccc6)n5)cc34)CC2)c1",
        "output": "50"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)/C=C/c1ccc(-c2ccc(OCN3C(=O)c4ccccc4C3=O)c(C34CC5CC(CC(C5)C3)C4)c2)cc1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)/C=C/c1ccc(-c2ccc(OCN3C(=O)c4ccccc4C3=O)c(C34CC5CC(CC(C5)C3)C4)c2)cc1",
        "output": "158"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)C=O.CNC(C)(C)C.Cc1ccccc1.O=C(O)c1cccc(Oc2ccc([N+](=O)[O-])cc2Cl)c1.O=S(Cl)Cl>>CN(C(=O)c1cccc(Oc2ccc([N+](=O)[O-])cc2Cl)c1)C(C)(C)C",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)C(F)(Oc1cccc2c1cc(C)n2Cc1ccccc1)C(F)(F)Br.O.O.[Li+].[OH-]>>Cc1cc2c(OC(F)(C(=O)O)C(F)(F)Br)cccc2n1Cc1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CON(C)C(=O)c1n[nH]c2ccccc12.ClCCl.II.O=C(Oc1cccc(I)c1OC(=O)C(F)(F)F)C(F)(F)F.O=S([O-])O.[Na+]>>CON(C)C(=O)c1n[nH]c2ccc(I)cc12",
        "output": "372"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc(N)ccc1Cl.Cl.Cl[Sn](Cl)(Cl)Cl.O.O=N[O-].[Na+]>>COc1cc(NN)ccc1Cl",
        "output": "109"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.CN1CCCC1=O.Cc1cn2cc(-c3ccccc3)c(-c3ccc(C=O)cc3)nc2n1.O=C([O-])O.[Na+].[Na+].c1ccc2nc(C3CCNCC3)cnc2c1>>Cc1cn2cc(-c3ccccc3)c(-c3ccc(CN4CCC(c5cnc6ccccc6n5)CC4)cc3)nc2n1",
        "output": "567"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCI.CCO.CCOC(C)=O.CC[O-].CN(C)P(=O)(N(C)C)N(C)C.O=C(O)c1c(-c2cnccn2)ssc1=S.[Na+]>>CCCCOC(=O)c1c(-c2cnccn2)ssc1=S",
        "output": "196"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cc1cc(C#N)cc(C)c1Br.O.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>Cc1cc(-c2nnn[nH]2)cc(C)c1Br",
        "output": "390"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(C)=O.N#Cc1ccc(F)cc1C(F)(F)F.OC1CCNCC1>>N#Cc1ccc(N2CCC(O)CC2)cc1C(F)(F)F",
        "output": "26"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.CNOC.COc1cccc(C(=O)O)c1OC.Cl.ClCCl.O=C(n1ccnc1)n1ccnc1>>COc1cccc(C(=O)N(C)OC)c1OC",
        "output": "828"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "NS(=O)(=O)C1CC1.NS(=O)(=O)N1CC(F)C1.O=C(O)c1cc(C2CC2)c(OC2CC3(C2)CN(Cc2ccc(F)cc2Cl)C3)cc1F.O=C(O)c1cc(C2CC2)c(O[C@@H]2CCCN(Cc3cc(Cl)cc(Cl)c3)C2)cc1F>>O=C(NS(=O)(=O)N1CC(F)C1)c1cc(C2CC2)c(OC2CC3(C2)CN(Cc2ccc(F)cc2Cl)C3)cc1F",
        "output": "886"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O.O=C(O)c1ccc([N+](=O)[O-])c(O)c1.O=S(=O)(O)O>>COC(=O)c1ccc([N+](=O)[O-])c(O)c1",
        "output": "33"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)N1CCNCC1.CN(C)C=O.Cc1cc(OCCCl)nn1-c1ccc(Cl)c(Cl)c1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CCOC(=O)N1CCN(CCOc2cc(C)n(-c3ccc(Cl)c(Cl)c3)n2)CC1",
        "output": "138"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCSc1nc2ccc(OCCCCCC(=O)OC)cc2n1-c1ccc(C)cc1.[Li+].[OH-]>>CCCSc1nc2ccc(OCCCCCC(=O)O)cc2n1-c1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC1(C(=O)O)CCN(c2ncnc3[nH]ccc23)CC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCCC1=O.COCCC(N)c1ccc(Cl)cc1.F[P-](F)(F)(F)(F)F>>COCCC(NC(=O)C1(NC(=O)OC(C)(C)C)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1",
        "output": "599"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1NCCn2c(-c3ccncn3)nnc21.O=C(O)c1cc2ncc(Br)cn2n1>>CC1c2nnc(-c3ccncn3)n2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "663"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CN(C)C=O.COc1ccc(N(C)C(=O)CC(CCOS(C)(=O)=O)c2ccc(Cl)c(Cl)c2)cc1.O=C([O-])[O-].OC1(c2ccccc2)CCNCC1.[K+].[K+]>>COc1ccc(N(C)C(=O)CC(CCN2CCC(O)(c3ccccc3)CC2)c2ccc(Cl)c(Cl)c2)cc1",
        "output": "496"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.COc1c(-c2coc(C(=O)O)c2)cccc1[N+](=O)[O-].O=C[O-].[NH4+].[Pd]>>COc1c(N)cccc1-c1coc(C(=O)O)c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(C)=O.COc1ccc2cc(C3=CCN(Cc4ccccc4)CC3)ccc2c1.O=[Pt].[H][H]>>COc1ccc2cc(C3CCN(Cc4ccccc4)CC3)ccc2c1",
        "output": "806"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.O.[N-]=[N+]=NCCCCCc1ccc(Oc2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NCCCCCc1ccc(Oc2ccccc2)cc1",
        "output": "89"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)C12CCC(C(=O)OC)(CC1)CC2.O.[Na+].[OH-]>>COC(=O)C12CCC(C(=O)O)(CC1)CC2",
        "output": "361"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc2c(c1)CCc1c-2noc1-c1onc(-c2ccccc2)c1C(F)(F)F.ClCCl>>Oc1ccc2c(c1)CCc1c-2noc1-c1onc(-c2ccccc2)c1C(F)(F)F",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.C1COCCO1.CS(=O)(=O)c1ccc(B(O)O)cc1.Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)ncc1Br.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)ncc1-c1ccc(S(C)(=O)=O)cc1",
        "output": "833"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)NC(C)C.CCCCCC.Fc1cccc(Br)c1.II.[Li]CCCC>>Fc1cccc(Br)c1I",
        "output": "372"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1Cn2c(cc(Cl)nc2=O)N1C.N#Cc1cc(CO)ccc1F>>CC1Cn2c(cc(OCc3ccc(F)c(C#N)c3)nc2=O)N1C",
        "output": "653"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=S)N1CCCC(=O)O.ClCCCl.ClCCl.NCCOCCOCCOCCOC12CC3CC(CC(C3)C1)C2.On1nnc2ccccc21>>CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=S)N1CCCC(=O)NCCOCCOCCOCCOC12CC3CC(CC(C3)C1)C2",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)c1cc([N+](=O)[O-])cc2nc(Nc3c(C)cc(C)cc3C)sc12.[Na+].[OH-]>>Cc1cc(C)c(Nc2nc3cc([N+](=O)[O-])cc(C(=O)O)c3s2)c(C)c1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.O=CCC1(c2ccccc2)CCN(C(=O)c2ccccc2)CC1.O=C[O-].[Na+].[Na+].c1cncc(Cc2noc(C3CCNCC3)n2)c1>>O=C(c1ccccc1)N1CCC(CCN2CCC(c3nc(Cc4cccnc4)no3)CC2)(c2ccccc2)CC1",
        "output": "484"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.CCOC(C)=O.Cc1cc(O[Si](C)(C)C(C)(C)C)ccc1Br.O=C1CCC(=O)N1Br>>CC(C)(C)[Si](C)(C)Oc1ccc(Br)c(CBr)c1",
        "output": "29"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CI.Cc1ccc(S(=O)(=O)OCCOc2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1ccc(S(=O)(=O)OCCOc2ccc3c(c2)c(S(=O)(=O)c2cccc4ccccc24)nn3C)cc1",
        "output": "229"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CO.CS(=O)(=O)N1CCc2ccc([N+](=O)[O-])cc2C1.[Pd]>>CS(=O)(=O)N1CCc2ccc(N)cc2C1",
        "output": "71"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN1C2CCCC1CC(N)C2.Cc1ccc(-c2nc3c(C(=O)O)cc(Cl)cc3o2)cc1.Cl.Cl.Cl.On1nnc2ccccc21>>Cc1ccc(-c2nc3c(C(=O)NC4CC5CCCC(C4)N5C)cc(Cl)cc3o2)cc1",
        "output": "674"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)[SiH2]OC(C)(C)c1c(Br)cccc1-n1ccc2cc(C3CC3)ccc2c1=O.ClCCl.Cn1cc(B2OC(C)(C)C(C)(C)O2)cc(Nc2ccc(C(=O)N3CCOCC3)cn2)c1=O.O.O=C([O-])[O-].[Cs+].[Cs+]>>Cn1cc(-c2cccc(-n3ccc4cc(C5CC5)ccc4c3=O)c2C(C)(C)O[SiH2]C(C)(C)C)cc(Nc2ccc(C(=O)N3CCOCC3)cn2)c1=O",
        "output": "954"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.COc1c(C)cc(-c2nc3c(CC(C)C)nc(Cc4ccc(Cl)cc4)nc3o2)cc1C>>Cc1cc(-c2nc3c(CC(C)C)nc(Cc4ccc(Cl)cc4)nc3o2)cc(C)c1O",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCCCP(c1ccccc1)c1ccccc1.CN(C)CCN(C)C.Cc1ccccc1.Cn1nnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2cc(C(F)(F)F)cnc2Cl)n1.[C-]#N.[Pd+2]>>Cn1nnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2cc(C(F)(F)F)cnc2C#N)n1",
        "output": "726"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCn1cc(-c2ccc(C(=O)O)cc2)nc1/C=C/c1ccc(Br)cc1.CN>>CCn1cc(-c2ccc(C(=O)NC)cc2)nc1/C=C/c1ccc(Br)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1ccc(Sc2ncc(Cl)cn2)cc1.ClCCl>>Oc1ccc(Sc2ncc(Cl)cn2)cc1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cn1c(CN2CCC(C(C)(C)O)CC2)nc2c(N3CCOCC3)nc(Cl)nc21.c1ccc(CN(Cc2ccccc2)c2nc3ccccc3[nH]2)cc1>>Cn1c(CN2CCC(C(C)(C)O)CC2)nc2c(N3CCOCC3)nc(-n3c(N(Cc4ccccc4)Cc4ccccc4)nc4ccccc43)nc21",
        "output": "916"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)NNC(=O)[C@@H]2CC[C@@H]3CN2C(=O)N3OS(=O)(=O)O)CC1.O=C(O)C(F)(F)F.c1cc[nH+]cc1>>O=C(NNC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)O)C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.Clc1ncc(Br)c(Cl)n1.NC1CCCC1>>Clc1ncc(Br)c(NC2CCCC2)n1",
        "output": "166"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC(=O)Nc1ccc2c(c1)CCC2=O.O=C1CCC(=O)N1Br>>CC(=O)Nc1ccc2c(c1Br)CCC2=O",
        "output": "4"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N1CCNCC1.CCCOc1cc(F)ccc1[N+](=O)[O-].CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCCOc1cc(N2CCN(C(C)=O)CC2)ccc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)[C@H](CNC(=O)c1cccs1)NC(=O)c1sc(C(=O)NCc2cccc3[nH]ncc23)cc1C(C)C.Cl.O.O.[Li+].[OH-]>>CC(C)c1cc(C(=O)NCc2cccc3[nH]ncc23)sc1C(=O)N[C@@H](CNC(=O)c1cccs1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)CC(C)(C)C(c1cccc(S(=O)(=O)N(C)C)c1)N2.[Na+].[OH-]>>CN(C)S(=O)(=O)c1cccc(C2Nc3ccc(C(=O)O)cc3CC2(C)C)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CO.COC(=O)c1cccc(-c2ncc(N3CCN(C(=O)OC(C)(C)C)CC3)cn2)c1.ClCCl.O=S(=O)([O-])[O-].[H-].[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCN(c2cnc(-c3cccc(CO)c3)nc2)CC1",
        "output": "444"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.O=CCCc1cc(-c2cccc([N+](=O)[O-])c2)no1.[Na+].c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>O=[N+]([O-])c1cccc(-c2cc(CCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)c1",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.CN(C)c1ccncc1.Oc1ccc(Cc2cc(Br)sc2Cl)cc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1ccc(Cc2cc(Br)sc2Cl)cc1",
        "output": "746"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.COc1ccc(NC(=O)OC[C@H]2C[C@@H](NS(=O)(=O)c3cc(Br)ccc3Br)CN2)cc1.ClCCl.N#CBr.NC(CO)(CO)CO>>COc1ccc(NC(=O)OC[C@H]2C[C@@H](NS(=O)(=O)c3cc(Br)ccc3Br)CN2C#N)cc1",
        "output": "532"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NC(=O)C1c2ccccc2Oc2ccccc21.O=P(Cl)(Cl)Cl.[NH4+].[OH-]>>N#CC1c2ccccc2Oc2ccccc21",
        "output": "172"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1ccc2cc(CCNS(=O)(=O)C(C)C)ccc2c1.ClCCl>>CC(C)S(=O)(=O)NCCc1ccc2cc(O)ccc2c1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(O)CC1CCNCC1.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1ccc2[nH]c(C(=O)O)cc2c1.Cl.Cl.On1nnc2ccccc21>>Cc1ccc2[nH]c(C(=O)N3CCC(CC(C)(C)O)CC3)cc2c1",
        "output": "605"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cl.O=C(O)Cc1ccc2c(c1)CCc1cccnc1O2.O=C([O-])O.[Na+]>>CCOC(=O)Cc1ccc2c(c1)CCc1cccnc1O2",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)c1cccc([C@H](C)N)c1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cccc(Cn2c(C)nc3cc(C(=O)O)ccc32)c1.F[P-](F)(F)(F)(F)F>>COc1cccc(Cn2c(C)nc3cc(C(=O)N[C@@H](C)c4cccc(C(C)C)c4)ccc32)c1",
        "output": "753"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(Cl)c(B(O)O)c1.Nc1ccc(Br)c(F)c1>>COc1ccc(Cl)c(-c2ccc(N)cc2F)c1",
        "output": "837"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COCCBr.Cc1cccc2c(=O)oc3c(c12)COC(C1CCNCC1)C3.Cl.O.O=C([O-])[O-].[K+].[K+]>>COCCN1CCC(C2Cc3oc(=O)c4cccc(C)c4c3CO2)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CCOC(=O)c1nc(N)sc1Br.Cc1csc(Br)[n+]1C.ClCCl.[Br-]>>CCOC(=O)c1nc(NC(C)=O)sc1Br",
        "output": "681"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCOC(C)=O.NC(=O)c1ccc(Cl)nc1NCCOCc1ccccc1.O=P(Cl)(Cl)Cl.[Na+].[OH-].c1ccncc1>>N#Cc1ccc(Cl)nc1NCCOCc1ccccc1",
        "output": "624"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C1COCCO1.CC(C)C[Al+]CC(C)C.CCOC(=O)c1ccc(-c2cc3c(Cl)ncnc3[nH]2)cc1.ClCCl.[Al+3].[H-].[H-].[H-].[H-].[H-].[Li+]>>OCc1ccc(-c2cc3c(Cl)ncnc3[nH]2)cc1",
        "output": "311"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1cc(Oc2nccc3occc23)ccc1Br.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cc(Oc2nccc3occc23)ccc1B1OC(C)(C)C(C)(C)O1",
        "output": "942"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COc1ccc(CN2CCOC[C@H]2COc2cc(C#N)cc([N+](=O)[O-])c2Cl)c(OC)c1.ClCCl.[Cl-].[NH4+].[Zn]>>COc1ccc(CN2CCOC[C@H]2COc2cc(C#N)cc(N)c2Cl)c(OC)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C12CCC(N)(CC1)CC2.CN(C)C=O.Cl.NC(=O)[C@@H]1C[C@H](F)CN1C(=O)CCl.O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CCOC(=O)C12CCC(NCC(=O)N3C[C@@H](F)C[C@H]3C(N)=O)(CC1)CC2",
        "output": "330"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCC([NH2+]C2CCCCC2)CC1.CC(C)(C)OC(=O)CC[C@H](N=[N+]=[N-])C(=O)[O-].CCOC(C)=O>>CC(C)(C)OC(=O)CC[C@H](N=[N+]=[N-])C(=O)O",
        "output": "151"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)CC1CCc2cc(OCc3ccc(-c4ccccc4)cc3)ccc2C1.O=C([O-])[C@H](O)[C@@H](O)C(=O)[O-].[Al+3].[H-].[H-].[H-].[H-].[K+].[Li+].[Na+]>>OCCC1CCc2cc(OCc3ccc(-c4ccccc4)cc3)ccc2C1",
        "output": "343"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.O=CN1CCOC(S(=O)(=O)c2cc([N+](=O)[O-])cc(C(F)(F)F)c2)C1.[Pd]>>Nc1cc(C(F)(F)F)cc(S(=O)(=O)C2CN(C=O)CCO2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.CC(=O)O.Cc1ncc(-c2c(C)nc(-c3cccc(F)c3OCc3ccccc3)n(CCc3ccccc3)c2=O)s1>>Cc1ncc(-c2c(C)nc(-c3cccc(F)c3O)n(CCc3ccccc3)c2=O)s1",
        "output": "23"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.Fc1ccc(-c2ccn3c2CNCC3)cc1.O=C(Nc1ccc(F)c(Cl)c1)Oc1ccccc1>>O=C(Nc1ccc(F)c(Cl)c1)N1CCn2ccc(-c3ccc(F)cc3)c2C1",
        "output": "525"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "NCCCOc1cccc(CN2CCCCC2)c1.O=CO.O=C[O-].[Na+]>>O=CNCCCOc1cccc(CN2CCCCC2)c1",
        "output": "370"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)Nc1cccc([N+](=O)[O-])c1OCc1ccccc1.CO.Cc1ccc(S(=O)(=O)O)cc1.O.O=C([O-])O.[Na+]>>Nc1cccc([N+](=O)[O-])c1OCc1ccccc1",
        "output": "782"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Nc1ccc2cc(CN3CCCCC3)ccc2c1.O=C(O)C(F)(F)F>>Nc1ccc2cc(CN3CCCCC3)ccc2c1",
        "output": "782"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.CN1CCC(c2nc(Br)c3c(Cl)nccn23)CC1=O.[NH4+].[OH-]>>CN1CCC(c2nc(Br)c3c(N)nccn23)CC1=O",
        "output": "682"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)CCOC(=O)c1nc2ccccc2cc1I.CC(C)C[Al+]CC(C)C.CCO.CCOC(=O)c1nc2ccccc2cc1I.Cc1ccccc1.O.[BH4-].[H-].[Na+]>>OCc1nc2ccccc2cc1I",
        "output": "711"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)C=O.Cl.O.O.O=C(O)c1cccc(C(F)(F)F)c1.O=C1CCNCC1.On1nnc2ccccc21>>O=C1CCN(C(=O)c2cccc(C(F)(F)F)c2)CC1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.CCOC(C)=O.COC(=O)c1coc(CO)n1.N#N.[Cl-].[NH4+].c1c[nH]cn1>>COC(=O)c1coc(CO[Si](C)(C)C(C)(C)C)n1",
        "output": "193"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCC(C)(C)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)OCC)cs1.CO.Cl.[Na+].[OH-]>>CCCCC(C)(C)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CCN(CC)CC.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cccc([N+](=O)[O-])c1>>O=C(c1cccc([N+](=O)[O-])c1)N1CCOCC1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC1CCNCC1.CS(C)=O.N#Cc1c(F)cc(F)cc1F.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)NC1CCN(c2cc(F)c(C#N)c(F)c2)CC1",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCO[C@@H]1CNC[C@H](O)[C@H]1c1ccc(O)cc1.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])O.[Na+].[Na+].[OH-]>>CCO[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H](O)[C@H]1c1ccc(O)cc1",
        "output": "694"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Br.CC(=O)O.CC(=O)O.COc1cc(N)c(Cl)cc1Cl.O=N[O-].O=S(=O)(O)O.[Cu]Br.[Na+].[Na+].[OH-]>>COc1cc(Br)c(Cl)cc1Cl",
        "output": "373"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)CCCN(C)c1ccc([N+](=O)[O-])cc1C(F)(F)F.CO.[Ni]>>CN(C)CCCN(C)c1ccc(N)cc1C(F)(F)F",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#Cc1ccc(C(C)C)cc1.CCN(CC)CC.Nc1ncccc1Br.O>>CC(C)c1ccc(C#Cc2cccnc2N)cc1",
        "output": "719"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1ccc(O)cc1.CO.O=Cc1ccc2c(c1)OCO2.[Na+].[OH-]>>O=C(C=Cc1ccc2c(c1)OCO2)c1ccc(O)cc1",
        "output": "295"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1nc2cc(C)c(C)c(CO)c2nc1OC.Cc1ccccc1.O=S(Cl)Cl.c1ccncc1>>COc1nc2cc(C)c(C)c(CCl)c2nc1OC",
        "output": "477"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCc1ccc(N)cc1.CN(C)c1ccc(C=O)cc1>>CCc1ccc(NCc2ccc(N(C)C)cc2)cc1",
        "output": "359"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCC.COC(=O)C(Cl)Cc1ccc(CCOc2ccc(OCc3ccccc3)cc2)cc1.CSC.ClCCl.FB(F)F.O>>COC(=O)C(Cl)Cc1ccc(CCOc2ccc(O)cc2)cc1",
        "output": "23"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.NCCO.O=C(Cl)c1ccc([N+](=O)[O-])cc1.O=C([O-])O.[Na+]>>O=C(NCCO)c1ccc([N+](=O)[O-])cc1",
        "output": "271"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)OCc2cc([C@@H](O)CBr)ccc2O1.CC[Si](Cl)(CC)CC.CN(C)C=O.c1c[nH]cn1>>CC[Si](CC)(CC)O[C@@H](CBr)c1ccc2c(c1)COC(C)(C)O2",
        "output": "193"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CI.Cc1cccc(SC2(CO)CCN(C(=O)OC(C)(C)C)CC2)c1.[H-].[K+]>>COCC1(Sc2cccc(C)c2)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "140"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1nc(Cl)ccc1Br.Cc1ccccc1.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c(B(O)O)c1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1nc(Cl)ccc1-c1cc([N+](=O)[O-])ccc1F",
        "output": "833"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.O=C(NC1CCNCC1)c1cc(=O)c2ccc(F)cc2o1.O=Cc1cccc(O)c1.[Na+]>>O=C(NC1CCN(Cc2cccc(O)c2)CC1)c1cc(=O)c2ccc(F)cc2o1",
        "output": "567"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1scc(Cl)c1-c1nc[nH]n1.O=C(O)Cn1c(=O)ccc2ncccc21>>O=C(Cn1c(=O)ccc2ncccc21)Nc1scc(Cl)c1-c1nc[nH]n1",
        "output": "882"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.CON=C(COc1cccc(C(F)(F)F)c1)CN1CCc2cc([N+](=O)[O-])ccc21.[Pd]>>CON=C(COc1cccc(C(F)(F)F)c1)CN1CCc2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)c1ccc(N=C=O)cc1.ClCCl.Clc1cccnc1N1CC2CCC(C1)N2>>CC(C)(C)c1ccc(NC(=O)N2C3CCC2CN(c2ncccc2Cl)C3)cc1",
        "output": "323"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(-c2nnc3n2CCN(C(=O)OC(C)(C)C)C3)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1.ClCCl.O=C(O)C(F)(F)F>>COc1cc(-c2nnc3n2CCNC3)ccc1Nc1cc2cc(-c3cnn(CC(C)(C)O)c3)ccc2cn1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCNCC2)c1.Cc1ccc(Sc2ccc(C=O)cc2[N+](=O)[O-])cc1>>Cc1ccc(Sc2ccc(CN3CCC(c4cccc(NC(=O)C(C)C)c4)CC3)cc2[N+](=O)[O-])cc1",
        "output": "567"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C=O.Cc1ccccc1.Nc1ccc(SC(F)(F)F)cc1.O=C(O)c1cnc(Cl)c(Br)c1.O=S(Cl)Cl>>O=C(Nc1ccc(SC(F)(F)F)cc1)c1cnc(Cl)c(Br)c1",
        "output": "739"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Oc1ccc(C(C)=O)cc1.[H][H].[Ni]>>CC(=O)Oc1ccc(C(C)O)cc1",
        "output": "24"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.COc1ccc2c(c1)c(C)c(CCC(=O)O)n2C(=O)c1ccc(Cl)cc1.CS(N)(=O)=O.ClCCl.[N-]=[N+]=C1CCCCC2=CCCCC21>>COc1ccc2c(c1)c(C)c(CCC(=O)NS(C)(=O)=O)n2C(=O)c1ccc(Cl)cc1",
        "output": "644"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.OCc1ccc(O)c(Br)n1.[Mn+4].[O-2].[O-2]>>O=Cc1ccc(O)c(Br)n1",
        "output": "263"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1nc(CO)cn1C.ClCCl.[Mn+4].[O-2].[O-2]>>Cc1nc(C=O)cn1C",
        "output": "287"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1ccc(Oc2c(C)cc(Nc3nnn[nH]3)cc2C)cc1C(C)C.O>>Cc1cc(Nc2nnn[nH]2)cc(C)c1Oc1ccc(O)c(C(C)C)c1",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.ClCCl.O=[N+]([O-])c1ccc(F)cc1.OCCNCCO>>O=[N+]([O-])c1ccc(N(CCO)CCO)cc1",
        "output": "26"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(=O)Cl.Cc1csc(C2(Nc3cccc(Cl)c3)CCN(Cc3ccccc3)CC2)n1.ClC(Cl)Cl>>CCC(=O)N(c1cccc(Cl)c1)C1(c2nc(C)cs2)CCN(Cc2ccccc2)CC1",
        "output": "160"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COCCOC.Clc1cnc(Cl)c(Cl)c1.Cn1nc(-c2c(F)cccc2Cl)nc1-c1ccc(CO)c(Cl)c1.O.[H-].[Na+]>>Cn1nc(-c2c(F)cccc2Cl)nc1-c1ccc(COc2ncc(Cl)cc2Cl)c(Cl)c1",
        "output": "433"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(C)c1cc(Cl)nc(Cl)n1.CCN(CC)CC.Cc1ccc(N)cc1>>Cc1ccc(Nc2cc(C(C)C)nc(Cl)n2)cc1",
        "output": "161"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCOC(=O)Nc1ccc2cc(Cl)ccc2c1.Cl.O.O=C1CCC(=O)N1Cl>>CCOC(=O)Nc1ccc2cc(Cl)ccc2c1Cl",
        "output": "121"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.N#Cc1ccc(-c2ccc([C@@]3(N)CCOc4cccnc43)cc2)cc1.O=C(Cl)c1ccc(F)cc1>>N#Cc1ccc(-c2ccc([C@@]3(NC(=O)c4ccc(F)cc4)CCOc4cccnc43)cc2)cc1",
        "output": "411"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)CCCN.O=C(O)c1ccccc1Nc1ccnc2cc(C(F)(F)F)ccc12>>CN(C)CCCNC(=O)c1ccccc1Nc1ccnc2cc(C(F)(F)F)ccc12",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CCO.CCOc1cc(C=O)ccc1Cl.CCOc1cc(C=O)ccc1F.Cl.Cl.O=C(O)c1ccc(F)c(O)c1.[BH3-]C#N.[Na+].c1cc2nc(NC3CCNCC3)oc2cn1>>CCOc1cc(CN2CCC(Nc3nc4ccncc4o3)CC2)ccc1F",
        "output": "567"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCC.COC(=O)Cc1ccc(C(=O)Cl)cc1.OCC1CO1.c1ccncc1>>COC(=O)Cc1ccc(C(=O)OCC2CO2)cc1",
        "output": "51"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOc1ccc(-c2ncc(C(=O)N(C3CCNCC3)C3CC3)cn2)cn1.CCc1cnc(Cl)nc1.CN(C)C=O.O=C(O)C(F)(F)F>>CCOc1ccc(-c2ncc(C(=O)N(C3CC3)C3CCN(c4ncc(CC)cn4)CC3)cn2)cn1",
        "output": "36"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCOc1c(C2CCNCC2)ccc2c1CC[C@H](C)N2C(C)=O.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CCCOc1c(C2CCN(S(C)(=O)=O)CC2)ccc2c1CC[C@H](C)N2C(C)=O",
        "output": "584"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=C(Cc1ccccc1)c1ccc(Br)cc1.OCCO>>Brc1ccc(C2(Cc3ccccc3)OCCO2)cc1",
        "output": "93"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCCCC(O)CF.CCN(CC)CC.ClCCl.O=C(Cl)c1ccc(OCc2ccccc2)cc1>>CCCCCCCCC(CF)OC(=O)c1ccc(OCc2ccccc2)cc1",
        "output": "51"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2ccc(Cl)nc2)CC1.ClCCl.O=C(O)C(F)(F)F>>Clc1ccc(OC2CCNCC2)cn1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)[C@H](NC(=O)Oc1ccccc1)C(=O)O.CNCc1csc(C(C)C)n1.Cl.O.[H-].[Na+].[Na+].[OH-]>>CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)O)C(C)C)cs1",
        "output": "525"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.Cl[Pd]Cl.O=C([O-])[O-].O=[N+]([O-])c1ccc(B(O)O)cc1.Oc1ccc(Br)nc1.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=[N+]([O-])c1ccc(-c2ccc(O)cn2)cc1",
        "output": "869"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(C)=O.COC(=O)[C@@H]1CNC[C@H]1c1ccc(Cl)cc1.Cl.ClCCl>>COC(=O)[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1c1ccc(Cl)cc1",
        "output": "694"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CI.O.Oc1ccc(Br)cc1C12CC3CC(CC(C3)C1)C2.[H-].[Na+]>>COc1ccc(Br)cc1C12CC3CC(CC(C3)C1)C2",
        "output": "62"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1ccc2c(c1)C(C(=O)O)c1cc(O)c3cc(C)ccc3c1-2.O=S(=O)(O)O>>COC(=O)C1c2cc(C)ccc2-c2c1cc(O)c1cc(C)ccc21",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CNc1ccnc(N)c1.O=C(CBr)c1ccc(Br)cc1>>CNc1ccn2cc(-c3ccc(Br)cc3)nc2c1",
        "output": "508"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)c1cc(OC)c(C(=O)O)cc1Cl.NC1CCN(Cc2ccccc2)C1>>CCN(CC)c1cc(OC)c(C(=O)NC2CCN(Cc3ccccc3)C2)cc1Cl",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#CC.C1CCOC1.CCN(CC)CC.Nc1ncc(Br)cc1I.[Cu]I>>CC#Cc1cc(Br)cnc1N",
        "output": "819"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.ClC(Cl)Cl.FC(F)(F)Sc1ccc(CBr)cc1.Nc1ccc(Cl)cc1C(=O)NCC(=O)NCC1CCNCC1>>Nc1ccc(Cl)cc1C(=O)NCC(=O)NCC1CCN(Cc2ccc(SC(F)(F)F)cc2)CC1",
        "output": "248"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[O-].CC1(C)CC(=O)c2c([nH]c3c(Cl)cc(Cl)cc23)C1.CCOC(=O)CCCCCCBr.CN(C)C=O.[K+]>>CCOC(=O)CCCCCCn1c2c(c3cc(Cl)cc(Cl)c31)C(=O)CC(C)(C)C2",
        "output": "470"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COCCOc1nc2cc(C(F)(F)F)ccc2c(C)c1C(=O)NCc1cccc(F)c1.ClCCl>>Cc1c(C(=O)NCc2cccc(F)c2)c(OCCO)nc2cc(C(F)(F)F)ccc12",
        "output": "423"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.COCCOc1ccc(CCCN)c(Oc2ncc(C(F)(F)F)cc2Cl)c1.O=S(=O)(Cl)c1ccc(Cl)cc1Cl.[Cl-].[NH4+].c1ccncc1>>COCCOc1ccc(CCCNS(=O)(=O)c2ccc(Cl)cc2Cl)c(Oc2ncc(C(F)(F)F)cc2Cl)c1",
        "output": "43"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cl.Cl[Sn](Cl)(Cl)Cl.NC[C@H](O)c1ccc2nnnn2c1.O=C1CCN(c2ccc(CC3SC(=O)NC3=O)cc2)CC1>>O=C1NC(=O)C(Cc2ccc(N3CCC(NC[C@H](O)c4ccc5nnnn5c4)CC3)cc2)S1",
        "output": "236"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.N#CN=C(N)Nc1cccc(C(=O)NCC(=O)NC(CC(=O)OCc2ccccc2)c2ccccc2)c1.[Na+].[OH-]>>N#CN=C(N)Nc1cccc(C(=O)NCC(=O)NC(CC(=O)O)c2ccccc2)c1",
        "output": "186"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1cc(N)ccc1OCCN1CCCC1.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cc(Cl)ccc1[N+](=O)[O-]>>COc1cc(NC(=O)c2cc(Cl)ccc2[N+](=O)[O-])ccc1OCCN1CCCC1",
        "output": "817"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCOC(=O)Cl.CC(C)CNC(=O)C1CCN(C2CCCNCC2)CC1.CCN(CC)CC.ClCCl.O=C(O)C(F)(F)F>>C#CCOC(=O)N1CCCC(N2CCC(C(=O)NCC(C)C)CC2)CC1",
        "output": "219"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.Cc1nnc(NC(=O)c2csc([C@@H]3C[C@H]3N(CC3CCN(CCC(=O)OC(C)(C)C)CC3)C(=O)C(F)(F)F)c2)s1.O.[Na+].[OH-]>>Cc1nnc(NC(=O)c2csc([C@@H]3C[C@H]3NCC3CCN(CCC(=O)OC(C)(C)C)CC3)c2)s1",
        "output": "703"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)Oc1cc(F)ccc1OCCO.O.[H-].[Li+].[OH-]>>OCCOc1ccc(F)cc1O",
        "output": "22"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C([O-])[O-].O=Cc1ccc(F)cc1O.[K+].[K+]>>O=Cc1ccc(F)cc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CC[O-].ClCCBr.O.Sc1ccccc1.[Na+]>>ClCCSc1ccccc1",
        "output": "124"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCC1CC1.CCOC(=O)c1n[nH]cc1[N+](=O)[O-]>>CCOC(=O)c1nn(CC2CC2)cc1[N+](=O)[O-]",
        "output": "577"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Nc1ccc(N)nc1.O.O=C(Cl)OCC(Cl)(Cl)Cl.c1ccncc1>>Nc1ccc(NC(=O)OCC(Cl)(Cl)Cl)cn1",
        "output": "763"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1nc2ccccc2nc1N1CC2CNCC2C1.O=C(O)c1ccccc1-c1nnc[nH]1>>Cc1nc2ccccc2nc1N1CC2CN(C(=O)c3ccccc3-c3nnc[nH]3)CC2C1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C(=O)O)c1ccccn1.CC1CCN(c2nc(C(F)(F)F)ccc2CN)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F>>CC1CCN(c2nc(C(F)(F)F)ccc2CNC(=O)C(C)c2ccccn2)CC1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCCBr.O=[N+]([O-])c1ccc2[nH]c3ccccc3c2c1.[H-].[Na+]>>O=[N+]([O-])c1ccc2c(c1)c1ccccc1n2CCCCl",
        "output": "470"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1c(C)cnn1-c1ccccc1Cl.CO.[Na+].[OH-]>>Cc1cnn(-c2ccccc2Cl)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOCCOc1cc(C)c(-c2cccc(COc3ccc(C4CC4C(=O)OC)cc3)c2)c(C)c1.CO.Cl.O.[Na+].[OH-]>>CCOCCOc1cc(C)c(-c2cccc(COc3ccc(C4CC4C(=O)O)cc3)c2)c(C)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC.Cc1ccc(Br)cc1.Cc1ccc(C=O)cc1.[Cl-].[Mg].[NH4+]>>Cc1ccc(C(O)c2ccc(C)cc2)cc1",
        "output": "379"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)C1CCCN1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[B-](F)(F)F.O=C(O)c1cc2cc(C(=O)N3CCN(C4CCCC4)CC3)ccc2[nH]1>>CC(C)C1CCCN1C(=O)c1cc2cc(C(=O)N3CCN(C4CCCC4)CC3)ccc2[nH]1",
        "output": "605"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCNCC1.Cc1cc2cc(C(=O)O)nc(N3CCc4ccccc4C3)c2n1Cc1ccccc1>>Cc1cc2cc(C(=O)N3CCN(C)CC3)nc(N3CCc4ccccc4C3)c2n1Cc1ccccc1",
        "output": "605"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.CCOC(C)=O.NC1CC1.O=C(O)c1cccc(I)c1.O=S(Cl)Cl>>O=C(NC1CC1)c1cccc(I)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCn1c(CCC(F)(F)c2cccc(B3OC(C)(C)C(C)(C)O3)c2)nn(Cc2ccc(C(C)(C)C)cc2)c1=O.O=C([O-])O.O=S(=O)(Nc1ccc(Br)nc1)c1ccccc1.[Na+]>>CCn1c(CCC(F)(F)c2cccc(-c3ccc(NS(=O)(=O)c4ccccc4)cn3)c2)nn(Cc2ccc(C(C)(C)C)cc2)c1=O",
        "output": "939"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCCNCc1ccccc1Cl.COc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>NCCNCc1ccccc1Cl",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COc1cc2c(cc1Cl)C(=O)N(c1cnccc1C1CC1)CC2.ClCCl>>O=C1c2cc(Cl)c(O)cc2CCN1c1cnccc1C1CC1",
        "output": "786"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N(C)C.CC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.CS(=O)(=O)OCCOc1ccc(C2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1.[Na+].[OH-]>>CC(=O)N1CCN(CCOc2ccc(C3CCN(c4ccc5nnc(C(F)(F)F)n5n4)CC3)cc2)CC1",
        "output": "496"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(C)=O.COC(=O)C1(Oc2ccc([N+](=O)[O-])c(F)c2)CC1>>COC(=O)C1(Oc2ccc(N)c(F)c2)CC1",
        "output": "202"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCOC(C)=O.CC[C@@H](C)OC(=O)Nc1c(C)nnn1-c1ccc(Br)cc1.COC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1ccccc1.O.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd+2]>>CC[C@@H](C)OC(=O)Nc1c(C)nnn1-c1ccc(-c2ccc(C3(C(=O)OC)CC3)cc2)cc1",
        "output": "933"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CBr.CN(C)C=O.Cc1ccc2[nH]c(C)c(Sc3ccc(Cl)cc3)c2c1.[H-].[Na+]>>CCOC(=O)Cn1c(C)c(Sc2ccc(Cl)cc2)c2cc(C)ccc21",
        "output": "310"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COc1ccc(C(OC(c2ccccc2)C2CN(C(=O)CCCCCNC(=O)OCc3ccccc3)CC2O)c2ccc(OC)cc2)cc1>>COc1ccc(C(OC(c2ccccc2)C2CN(C(=O)CCCCCN)CC2O)c2ccc(OC)cc2)cc1",
        "output": "574"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cccc(C2=CCC(NC(=O)c3nc(Cl)c(CC)[nH]3)CC2)c1.O.[Li+].[OH-]>>CCc1[nH]c(C(=O)NC2CC=C(c3cccc(C(=O)O)c3)CC2)nc1Cl",
        "output": "5"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CS(=O)(=O)Cl.C[C@H](NC(=O)C(F)(F)F)[C@H](O)c1ccc(OCc2ccccc2)c(N)c1.O.c1ccncc1>>C[C@H](NC(=O)C(F)(F)F)[C@H](O)c1ccc(OCc2ccccc2)c(NS(C)(=O)=O)c1",
        "output": "194"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)Cc1cccc(O)c1.CN(C)C=O.N#Cc1ccccc1F.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)Cc1cccc(Oc2ccccc2C#N)c1",
        "output": "564"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCc1ccc(Br)cc1.C1CCOC1.CC(C)(C)[O-].CCNC(C)=O.CCOC(C)=O.O.[K+]>>CCN(Cc1ccc(Br)cc1)C(C)=O",
        "output": "774"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.COc1cccc2c1CCCC2NC(C)c1nc(-c2ccccc2)c(-c2ccccc2)o1.ClCCl.ClCCl>>CC(NC1CCCc2c(O)cccc21)c1nc(-c2ccccc2)c(-c2ccccc2)o1",
        "output": "732"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1c(-c2ccccn2)nc2c(F)cc(F)cc2c1Cl.Cc1ccccc1.Nc1cc(N2CCOCC2)cnc1N1CCOCC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1c(-c2ccccn2)nc2c(F)cc(F)cc2c1Nc1cc(N2CCOCC2)cnc1N1CCOCC1",
        "output": "859"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(COCCC(C)(C)OC)OC.O.O=CO>>COC(C)(C)CCOCC=O",
        "output": "234"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C(C)(C)C(=O)c1ccc(OCc2ccccc2)cc1.CO>>CCOC(=O)C(C)(C)C(=O)c1ccc(O)cc1",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)Oc1ccc(NC(=O)N2CCN(c3ncnc(N)c3C=NOCCN)CC2)cc1.CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.ClCCl>>CC(C)Oc1ccc(NC(=O)N2CCN(c3ncnc(N)c3C=NOCCNS(C)(=O)=O)CC2)cc1",
        "output": "493"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1c(I)cccc1C(=O)O.O=S(Cl)Cl>>COc1c(I)cccc1C(=O)Cl",
        "output": "3"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCC#Cc1cncc([N+](=O)[O-])c1.CCO.ClCCl.[K+].[OH-]>>CC(C)(C)OC(=O)NCC#Cc1cncc(N)c1",
        "output": "269"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)[N-]C(C)C.CCCc1ccc(Br)cc1F.CN(C)C=O.[Li+]>>CCCc1ccc(Br)c(C=O)c1F",
        "output": "239"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(=O)N1c2ccc(O)cc2C(C)(c2ccccc2)CC1(C)C.CCCC[N+](CCCC)(CCCC)CCCC.ClCC1CC1.O=C([O-])[O-].[Br-].[Cs+].[Cs+]>>CC(=O)N1c2ccc(OCC3CC3)cc2C(C)(c2ccccc2)CC1(C)C",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCC.COCOc1cccc([N+](=O)[O-])c1>>COCOc1cccc(N)c1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCC1CCCN1.Nc1cccc(F)n1.O>>COCC1CCCN1c1cccc(N)n1",
        "output": "756"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(C)=O.CSCc1cccc2c(C(CCOS(C)(=O)=O)c3ccc(C)cc3)c[nH]c12.[C-]#N.[K+]>>CSCc1cccc2c(C(CCC#N)c3ccc(C)cc3)c[nH]c12",
        "output": "705"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](Oc1ccc(B(O)O)cc1)(c1ccccc1)c1ccccc1.Fc1cc(Br)cnc1Br>>CC(C)(C)[Si](Oc1ccc(-c2ncc(Br)cc2F)cc1)(c1ccccc1)c1ccccc1",
        "output": "869"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(N)C(C)(C)C.N#Cc1ccc(N=C=S)cc1>>CC(NC(=S)Nc1ccc(C#N)cc1)C(C)(C)C",
        "output": "113"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCN(CC)CC.CCN=C=NCCCN(C)C.CO.COc1ccc(-c2cc(C(=O)O)c3[nH]c4cc(OC)ccc4c3n2)cc1.Cl.O.On1nnc2ccccc21.[Cl-].[NH4+]>>COc1ccc(-c2cc(C(N)=O)c3[nH]c4cc(OC)ccc4c3n2)cc1",
        "output": "704"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cc(Br)ccc1CO.OB(O)c1ccc(C(F)(F)F)cc1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)ccc1CO",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CS(=O)(=O)c1ccc(-c2cc(C(F)(F)F)nc(S(C)(=O)=O)n2)cc1.NCc1ccccn1>>CS(=O)(=O)c1ccc(-c2cc(C(F)(F)F)nc(NCc3ccccn3)n2)cc1",
        "output": "629"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc([N+](=O)[O-])c(C=O)c1.Cc1ccccc1.N#Cc1ccccc1N>>Cc1ccc([N+](=O)[O-])c(C=Nc2ccccc2C#N)c1",
        "output": "329"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.C[Si](C)(C)CCOCn1ncc2cc(-c3cccc(CN4CCCCC4)c3)c([N+](=O)[O-])cc21.[Pd]>>C[Si](C)(C)CCOCn1ncc2cc(-c3cccc(CN4CCCCC4)c3)c(N)cc21",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.ClCCl.N#C[C@@H]1C[C@H](F)CN1.O=C(Cl)CCl.O=S(=O)([O-])O.[Na+]>>N#C[C@@H]1C[C@H](F)CN1C(=O)CCl",
        "output": "125"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COc1ccc(CN(C)C2CCOCC2)cc1.ClCCl.O=C([O-])O.[Na+]>>CN(Cc1ccc(O)cc1)C1CCOCC1",
        "output": "207"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCN.COc1ccc2oc(-c3cc([N+](=O)[O-])ccc3F)nc2c1>>CCCNc1ccc([N+](=O)[O-])cc1-c1nc2cc(OC)ccc2o1",
        "output": "572"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#C[Si](C)(C)C.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.O=Cc1ccc(Br)cc1.[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C[Si](C)(C)C#Cc1ccc(C=O)cc1",
        "output": "671"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)Cc1c(C)nn(Cc2ccc(CSc3ccc(C(F)(F)F)cc3)cc2)c1C.ClCCl.O=C(OO)c1cccc(Cl)c1>>COC(=O)Cc1c(C)nn(Cc2ccc(CS(=O)c3ccc(C(F)(F)F)cc3)cc2)c1C",
        "output": "500"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)CCCCOc1cc2c(cc1N)nc(-c1ccccc1)n2-c1ccccc1.O=S(=O)(Cl)c1ccc(Cl)cc1>>COC(=O)CCCCOc1cc2c(cc1NS(=O)(=O)c1ccc(Cl)cc1)nc(-c1ccccc1)n2-c1ccccc1",
        "output": "68"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)CCc1ccc(O)cc1C.C[C@@H](CCOS(C)(=O)=O)Oc1ccc(C(F)(F)F)cc1Br>>COC(=O)CCc1ccc(OCC[C@H](C)Oc2ccc(C(F)(F)F)cc2Br)cc1C",
        "output": "702"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.COC(=O)[C@H]1C[C@@H]1C(=O)c1ccc2nc(C)sc2c1.[Na+].[OH-]>>Cc1nc2ccc(C(=O)[C@H]3C[C@@H]3C(=O)O)cc2s1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)c1ccc(C)cc1.CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.CO.ClCCl.[Br-].[Br-].[Br-]>>Cc1ccc(C(=O)CBr)cc1",
        "output": "360"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CI.CN(C)C=O.Cc1cc(Cl)nc(Cl)c1C(=O)O.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1c(C)cc(Cl)nc1Cl",
        "output": "415"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#Cc1ccc(CCC)cc1.CN(C)C=O.Cl.Cl[Pd]Cl.N#Cc1c(F)cc(I)cc1F.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCc1ccc(C#Cc2cc(F)c(C#N)c(F)c2)cc1",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CCO.COc1ccc(CNc2c(C(=O)NCc3ccc(F)cc3F)c(=O)n(OCc3ccccc3)c3ncc(Br)cc23)c(OC)c1>>COc1ccc(CNc2c(C(=O)NCc3ccc(F)cc3F)c(=O)n(OCc3ccccc3)c3ncc(C#CCO)cc23)c(OC)c1",
        "output": "719"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)c1ccc(Nc2cc(Cl)nc(N)n2)cc1.OCc1ccccc1C(F)(F)F.[H-].[Na+]>>CC(C)(C)c1ccc(Nc2cc(OCc3ccccc3C(F)(F)F)nc(N)n2)cc1",
        "output": "653"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.O=C(O)Cc1c[nH]c2ccc(Br)cc12.[Li]C(C)(C)C>>O=C(O)Cc1c[nH]c2ccc(B(O)O)cc12",
        "output": "832"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc2ncnc(Oc3ccc4c(C(=O)O)cccc4c3)c2cc1OC.Nc1ccc(F)cc1N>>COc1cc2ncnc(Oc3ccc4c(C(=O)Nc5ccc(F)cc5N)cccc4c3)c2cc1OC",
        "output": "50"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCCNCC1(c2ccc(CC(OCC)C(=O)OC)cc2)CC1.CCN(C(C)C)C(C)C.Cc1ccccc1.Cl.O=C=Nc1ccc(F)cc1F>>CCCCCCCN(CC1(c2ccc(CC(OCC)C(=O)OC)cc2)CC1)C(=O)Nc1ccc(F)cc1F",
        "output": "323"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)c1cc(Cl)cc(OC2CCOCC2)c1C.Cl.[Na+].[OH-]>>Cc1c(OC2CCOCC2)cc(Cl)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C(=O)CCl.N#Cc1ccc(-c2cccn3nc(Nc4ccc(C5CCNCC5)cc4)nc23)cc1>>CN(C)C(=O)CN1CCC(c2ccc(Nc3nc4c(-c5ccc(C#N)cc5)cccn4n3)cc2)CC1",
        "output": "340"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COCC(=O)Cl.N[C@@H]1CC[C@@H](NC(=O)c2c[nH]c3c(-c4ccc(F)cc4OCC4CC4)ncnc23)CC1>>COCC(=O)N[C@@H]1CC[C@@H](NC(=O)c2c[nH]c3c(-c4ccc(F)cc4OCC4CC4)ncnc23)CC1",
        "output": "45"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCC(Cc1ccc(OCCCOC2CCCCO2)cc1)C(=O)OCC.Cc1ccc(S(=O)(=O)O)cc1.O>>CCCCC(Cc1ccc(OCCCO)cc1)C(=O)OCC",
        "output": "543"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1=Cc2ccccc2C(C2CCNCC2)c2ccccc21.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.O=C(Cl)c1ccc(F)cc1>>O=C(c1ccc(F)cc1)N1CCC(C2c3ccccc3C=Cc3ccccc32)CC1",
        "output": "201"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#CCOc1ccccc1.CCCCCC.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=S(=O)(O)Cl>>CC#CCOc1ccc(S(=O)(=O)Cl)cc1",
        "output": "182"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O.FC(F)(F)c1cccc2c1CNCC2>>CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCc2cccc(C(F)(F)F)c2C1",
        "output": "794"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2F)cc1N.Cc1cn(-c2cccc(C(=O)CC(=O)OC(C)(C)C)c2)c(C)n1>>Cc1cn(-c2cccc(C(=O)CC(=O)Nc3cc(-c4ccccc4F)ccc3NC(=O)OC(C)(C)C)c2)c(C)n1",
        "output": "929"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.CCOC(C)=O.COc1cccc([C@H]2O[C@H](CC(=O)Nc3ccc(CCC(=O)O)cc3C)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC.O.c1ccncc1>>COc1cccc([C@H]2O[C@H](CC(=O)Nc3ccc(CCC(=O)O)cc3C)C(=O)N(CC(C)(C)COC(C)=O)c3ccc(Cl)cc32)c1OC",
        "output": "126"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.Nc1ccc(Cl)c(C(F)(F)F)c1.O=C(O)c1cc[n+]([O-])cc1.O=C(n1ccnc1)n1ccnc1>>O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)c1cc[n+]([O-])cc1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O=C(O)[C@H](O)CC1CCOCC1>>COC(=O)[C@H](O)CC1CCOCC1",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)CCC(COc2cc(F)c(C(=O)O)cc2C2CC2)CC1.CS(N)(=O)=O.NS(=O)(=O)N1CCC1.O=C(O)c1cc(C2CC2)c(OCC2(C(F)(F)F)CCCCC2)cc1F>>CC1(C)CCC(COc2cc(F)c(C(=O)NS(=O)(=O)N3CCC3)cc2C2CC2)CC1",
        "output": "886"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.O=S(Cl)Cl.OCc1ncc(Cl)cc1Cl>>ClCc1ncc(Cl)cc1Cl",
        "output": "594"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.Clc1cc(-c2ccccc2)c(Cl)nn1>>CC(C)(C)OC(=O)N1CCN(c2cc(-c3ccccc3)c(Cl)nn2)CC1",
        "output": "406"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CI.O=c1c2c[nH]c3ccccc3c-2nn1-c1ccc(Cl)cc1.[H-].[Na+]>>Cn1cc2c(=O)n(-c3ccc(Cl)cc3)nc-2c2ccccc21",
        "output": "191"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)N1CCc2ccc3c(c2CC1)C(O)CC3.CI.CN(C)C=O.O.[H-].[Na+]>>CCOC(=O)N1CCc2ccc3c(c2CC1)C(OC)CC3",
        "output": "140"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.COc1ccc2c(c1CC1CCN(C(=O)OC(C)(C)C)CC1)O/C(=C\\c1n[nH]c3ncccc13)C2=O.Cl.ClCCl>>COc1ccc2c(c1CC1CCNCC1)O/C(=C\\c1n[nH]c3ncccc13)C2=O",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CCBr)C(=O)OC1CCCCC1.CN(C)C=O.COc1cc2c(Oc3ccc(NC(=O)c4ccccc4)cc3)ccnc2cc1O.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(Oc3ccc(NC(=O)c4ccccc4)cc3)ccnc2cc1OCC[C@H](NC(=O)OC(C)(C)C)C(=O)OC1CCCCC1",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(Br)ccc1N.Cl.Cl[Sn](Cl)(Cl)Cl.O.O=N[O-].[Na+]>>COc1cc(Br)ccc1NN",
        "output": "109"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CI.CN(C)C=O.COC(=O)c1ccc(F)c(-c2c(F)cc(CO)cc2F)n1.O.[H-].[Na+]>>COCc1cc(F)c(-c2nc(C(=O)OC)ccc2F)c(F)c1",
        "output": "140"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCCc1ccccc1.CC#N.CCCCC.O=c1cc(O)ccn1Cc1cccc(F)c1>>O=c1cc(OCCc2ccccc2)ccn1Cc1cccc(F)c1",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCBr.CN(C)C=O.O.Oc1cccc2cnccc12.[H-].[Na+]>>CCCOc1cccc2cnccc12",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cn(CCF)c2cc(/C=C/c3nc(C(C)C)cs3)ccc2c1=O.CO.Cl.O.[Na+].[OH-]>>CC(C)c1csc(/C=C/c2ccc3c(=O)c(C(=O)O)cn(CCF)c3c2)n1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N(CC1CC1)[C@@H]1C[C@H]1c1ccc(C(=O)O)s1.CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.NC1CCC(F)(F)CC1.O>>CC(C)(C)OC(=O)N(CC1CC1)[C@@H]1C[C@H]1c1ccc(C(=O)NC2CCC(F)(F)CC2)s1",
        "output": "736"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCCCCc1cccc(S(C)(=O)=O)c1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>CS(=O)(=O)c1cccc(CCCCO)c1",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)NC1(CO)CC1.N#Cc1c([N+](=O)[O-])cccc1[N+](=O)[O-]>>CC(C)(C)OC(=O)NC1(COc2cccc([N+](=O)[O-])c2C#N)CC1",
        "output": "499"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.C[C@@H](N)Cc1ccccc1.ClCCl.F[P-](F)(F)(F)(F)F.Nc1ccnc(C(F)(F)F)c1C(=O)O>>C[C@H](Cc1ccccc1)NC(=O)c1c(N)ccnc1C(F)(F)F",
        "output": "674"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CBr.CN(C)C=O.O=C(OCc1ccccc1)C1CCc2[nH]c3c(Cl)cccc3c2C1.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)Cn1c2c(c3cccc(Cl)c31)CC(C(=O)OCc1ccccc1)CC2",
        "output": "310"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)n1cnc2c([N+](=O)[O-])cccc21.CCO.[C].[Pd]>>CC(C)(C)OC(=O)n1cnc2c(N)cccc21",
        "output": "269"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.Cc1ccc(S(=O)(=O)O)cc1.O=C([O-])O.O=C1c2ccccc2C(=O)N1C1(c2ccc(Br)cc2)CC2(C1)OCCO2.[Na+]>>O=C1CC(c2ccc(Br)cc2)(N2C(=O)c3ccccc3C2=O)C1",
        "output": "251"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=C(C)C(=O)Cl.CCN(CC)CC.O=[N+]([O-])c1ccc(CO)cc1>>C=C(C)C(=O)OCc1ccc([N+](=O)[O-])cc1",
        "output": "320"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N[C@@H]1CCOC1.O=C(O)CN1CCN(c2cccc3c2cnn3-c2ccccc2F)C1=O>>O=C(CN1CCN(c2cccc3c2cnn3-c2ccccc2F)C1=O)N[C@@H]1CCOC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.CS(=O)(=O)Cl.Cc1cc(N)cc(C)c1S(=O)(=O)C[N+](=O)[O-].c1ccncc1>>Cc1cc(NS(C)(=O)=O)cc(C)c1S(=O)(=O)C[N+](=O)[O-]",
        "output": "194"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Nc1ccccc1N.O=C(O)CO>>OCc1nc2ccccc2[nH]1",
        "output": "512"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)COC[C@H](O)[C@H](O)/C=C/C=C/C#C/C=C/[C@H](O)COc1ccc(F)cc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Na+].[OH-]>>O=C(O)COC[C@H](O)[C@H](O)/C=C/C=C/C#C/C=C/[C@H](O)COc1ccc(F)cc1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Cl.CCN(CC)CC.CN(C)c1ccncc1.Cl.ClCCl.Cn1c2c(c3ccc(-n4ccc(OCc5ccc(F)cn5)cc4=O)cc31)CNCCC2>>CC(=O)N1CCCc2c(c3ccc(-n4ccc(OCc5ccc(F)cn5)cc4=O)cc3n2C)C1",
        "output": "125"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CS(=O)(=O)Cl.ClCCl.O[C@@H]1CC[C@@H](Nc2cc(-c3cc(NCC4CCOCC4)cnc3Cl)c(Cl)cn2)CC1>>CS(=O)(=O)O[C@@H]1CC[C@@H](Nc2cc(-c3cc(NCC4CCOCC4)cnc3Cl)c(Cl)cn2)CC1",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C)C=O.CNC.O=c1[nH]nc(-c2ccc(Cl)nc2)c2ccccc12>>CN(C)c1ccc(-c2n[nH]c(=O)c3ccccc23)cn1",
        "output": "220"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2c[nH]c3ccc(Cl)cc23)CC1.ClCCl.O=C(O)C(F)(F)F>>Clc1ccc2[nH]cc(C3CCNCC3)c2c1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.OCc1ccc(-c2noc(-c3ccc(C4CCCCC4)cc3)n2)cc1>>CS(=O)(=O)OCc1ccc(-c2noc(-c3ccc(C4CCCCC4)cc3)n2)cc1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#Cc1ccc(NC(C)C)nn1.CN1CCN(Cc2ccc3nc(-c4ccc(Cl)c(I)c4)[nH]c3c2)CC1>>CC(C)Nc1ccc(C#Cc2cc(-c3nc4ccc(CN5CCN(C)CC5)cc4[nH]3)ccc2Cl)nn1",
        "output": "664"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.C=C(C)C.N[C@@H](Cc1ccc(O)c(I)c1)C(=O)O.O.O=C([O-])O.O=S(=O)(O)O.[Na+]>>CC(C)(C)OC(=O)[C@@H](N)Cc1ccc(O)c(I)c1",
        "output": "511"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(C(C)C)C(C)C.CN(C)c1ccncc1.C[C@H]1CNC[C@@H](C)N1.ClCCl>>C[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H](C)N1",
        "output": "694"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.CS(C)=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Br)cn1.[I-].[K+].[K+]>>O=[N+]([O-])c1ccc(N2CCOCC2)cn1",
        "output": "597"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.N#Cc1cc(-c2ccc(C(F)(F)F)nc2)ncn1.[H][H].[Pd]>>NCc1cc(-c2ccc(C(F)(F)F)nc2)ncn1",
        "output": "205"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN3C(=O)c4ccccc4C3=O)ccc21.CO.NN.O>>CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN)ccc21",
        "output": "242"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.Cc1c(CN2CCN(C(=O)C3CCCC3)[C@@H](C)C2)cc(Cl)cc1[N+](=O)[O-].[Fe]>>Cc1c(N)cc(Cl)cc1CN1CCN(C(=O)C2CCCC2)[C@@H](C)C1",
        "output": "71"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)COc1ccc(C[C@H](NC(=O)c2ccccc2)C(=O)NCCCCc2ccccc2)cc1[N+](=O)[O-].CCOC(C)=O.Cl.O.[Na+].[OH-]>>O=C(O)COc1ccc(C[C@H](NC(=O)c2ccccc2)C(=O)NCCCCc2ccccc2)cc1[N+](=O)[O-]",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.CNCCC=C1c2ccccc2C=Cc2ccccc21.Cl.ClCCl.O=C([O-])O.[Na+]>>CN(CCC=C1c2ccccc2C=Cc2ccccc21)C(=O)CNC(=O)OC(C)(C)C",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.N#CC1(c2ccc([N+](=O)[O-])cc2)CCOCC1.[Pd]>>N#CC1(c2ccc(N)cc2)CCOCC1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Clc1ncc(Br)c(NC2CCN(Cc3ccccc3)CC2)n1.NCc1ccccn1>>Brc1cnc(NCc2ccccn2)nc1NC1CCN(Cc2ccccc2)CC1",
        "output": "544"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.Cc1cc(C)c(-n2c(C)c(C)c(C#N)c2N)c(C)c1>>CC(=O)Nc1c(C#N)c(C)c(C)n1-c1c(C)cc(C)cc1C",
        "output": "394"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Clc1ccc(Cl)nn1.Nc1cc(Cl)c(O)c(Cl)c1>>Nc1cc(Cl)c(Oc2ccc(Cl)nn2)c(Cl)c1",
        "output": "603"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C)C=O.Clc1ccc(CBr)cc1.O.O=c1[nH]cncc1Br.[H-].[Na+]>>O=c1c(Br)cncn1Cc1ccc(Cl)cc1",
        "output": "389"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)C(=O)CCSc1ccc(Cl)cc1N.O=S(=O)(Cl)c1ccc(Cl)c(C(F)(F)F)c1.c1ccncc1>>CCN(CC)C(=O)CCSc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1",
        "output": "68"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[C@H]1CNC[C@@H](C)N1.Nc1cccc(Cl)c1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>C[C@H]1CN(c2cccc(N)c2[N+](=O)[O-])C[C@@H](C)N1",
        "output": "105"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCOC(C)=O.Nc1ccc(-n2nccn2)nc1.O=C(Cl)Oc1ccccc1>>O=C(Nc1ccc(-n2nccn2)nc1)Oc1ccccc1",
        "output": "763"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CO.Oc1nc(Cl)nc2cnccc12>>CC(C)COc1nc(O)c2ccncc2n1",
        "output": "37"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)C=O.COc1ccc(C2(C(=O)O)CCCC2)cc1.Nc1ncc(Cc2ccccc2Cl)s1>>COc1ccc(C2(C(=O)Nc3ncc(Cc4ccccc4Cl)s3)CCCC2)cc1",
        "output": "681"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCC(O)C1(c2onc(-c3ccc(O[Si](C)(C)C(C)(C)C)cc3)c2-c2ccccc2)CC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.O.[Cl-].[F-].[NH4+]>>CCC(O)C1(c2onc(-c3ccc(O)cc3)c2-c2ccccc2)CC1",
        "output": "754"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCc1c(C)cccc1C(=O)OC.CO.[K+].[OH-]>>CCc1c(C)cccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cc2ccnc(Cl)c2[nH]1.CO.[K+].[OH-]>>O=C(O)c1cc2ccnc(Cl)c2[nH]1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CCn1ccc2cc(-c3noc(-c4cc(-c5ccccc5)c(C(F)(F)F)s4)n3)ccc21.CO.ClC(Cl)Cl.[Na+].[OH-]>>O=C(O)CCn1ccc2cc(-c3noc(-c4cc(-c5ccccc5)c(C(F)(F)F)s4)n3)ccc21",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN1CCCC1CCN.ClCCl.O=C(O)C1CCN(c2ncnc3scc(-c4ccccc4)c23)CC1.O=S(Cl)Cl>>CN1CCCC1CCNC(=O)C1CCN(c2ncnc3scc(-c4ccccc4)c23)CC1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCCC(CN)C1.Clc1ncc(Cl)c(Cl)n1>>CC(C)(C)OC(=O)N1CCCC(CNc2nc(Cl)ncc2Cl)C1",
        "output": "110"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1c(N)ccc(C(=O)OC)c1Cl.COC(=O)c1c(Cl)cc(N)c(C#C[Si](C)(C)C)c1Cl>>C#Cc1c(N)cc(Cl)c(C(=O)OC)c1Cl",
        "output": "337"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Nc1cc(CCOc2ccc([N+](=O)[O-])c3ccccc23)ccn1.CC(=O)O.CO.[Pt]>>CC(=O)Nc1cc(CCOc2ccc(N)c3ccccc23)ccn1",
        "output": "202"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CI.O=C(/C=C/c1cc(Cl)ccc1Cl)c1ccc(=O)[nH]c1.O=C([O-])[O-].[K+].[K+]>>Cn1cc(C(=O)/C=C/c2cc(Cl)ccc2Cl)ccc1=O",
        "output": "191"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CC=C(C(C(=O)N2CCN(CCCCc3cccc4ccccc34)CC2)c2ccc(F)cc2)CC1.CO.Cl>>CN1CC=C(C(C(=O)N2CCN(CCCCc3cccc4ccccc34)CC2)c2ccc(F)cc2)CC1",
        "output": "881"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCOC(C)=O.Cc1cc([N+](=O)[O-])n[nH]1.O=C([O-])[O-].OCCI.[K+].[K+]>>Cc1cc([N+](=O)[O-])nn1CCO",
        "output": "346"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Br.CC(=O)O.COc1cc(Br)ccc1N.ClCCl.O=C([O-])[O-].O=N[O-].[I-].[K+].[Na+].[Na+].[Na+]>>COc1cc(Br)ccc1I",
        "output": "200"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2nc(O)c(-c3nc4ccccc4s3)c(Cl)n2)CC1.CO.Cl>>Oc1nc(C2CCNCC2)nc(Cl)c1-c1nc2ccccc2s1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCC.CCCCCCCc1ccccc1Br.COB(OC)OC.[Li]C(C)(C)C>>CCCCCCCc1ccccc1B(O)O",
        "output": "789"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "NCc1ccc(F)cc1.O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12>>O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)NCc1ccc(F)cc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12",
        "output": "599"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#Cc1cnn2c(C(F)(F)F)cc(-c3cccc(C(F)(F)F)c3)nc12.NS(=O)(=O)c1ccc(Br)s1>>NS(=O)(=O)c1ccc(C#Cc2cnn3c(C(F)(F)F)cc(-c4cccc(C(F)(F)F)c4)nc23)s1",
        "output": "766"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCO.Fc1ccc2[nH]c(C3CNCCO3)nc2c1.Nc1nc(Cl)cc(Cl)n1>>Nc1nc(Cl)cc(N2CCOC(c3nc4cc(F)ccc4[nH]3)C2)n1",
        "output": "162"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NCCCCN.CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)O.CCN=C=NCCCN(C)C.CN1CCOCC1.Cl.ClCCl.O=c1c2ccccc2nnn1O>>CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)NCCCCNC(=O)OC(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOCC.N#CBr.c1ccc(CN2CC3CNCC(C3)C2)cc1>>N#CN1CC2CC(C1)CN(Cc1ccccc1)C2",
        "output": "532"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(Cc3cccc(CC(=O)OC)c3)C3CCNCC3)c2n1.CCN(CC)CC.CN1CCCC1=O.OCCBr>>CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(Cc3cccc(CC(=O)OC)c3)C3CCN(CCO)CC3)c2n1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=[N+]([O-])c1ccc(F)c(F)c1O.[Pd]>>Nc1ccc(F)c(F)c1O",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COc1ncccc1C=O.[BH4-].[Na+]>>COc1ncccc1CO",
        "output": "476"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NC1CCCCC1.O=C(O)CC1CCc2cc(Br)cc3[nH]c(=O)c(=O)n1c23>>O=C(CC1CCc2cc(Br)cc3[nH]c(=O)c(=O)n1c23)NC1CCCCC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNC1.CCc1cc(Br)ccc1CBr.ClCCl>>CCc1cc(Br)ccc1CN1CCCC1",
        "output": "248"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CC[C@@H](C(=O)OC(C)C)[C@H](O)C(=O)OC(C)C.CC#N.CC(=O)[O-].CC(=O)[O-].CCN(C(C)C)C(C)C.CCOc1ccc(Br)cc1.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.[Pd+2]>>CCOc1ccc(/C=C/C[C@@H](C(=O)OC(C)C)[C@H](O)C(=O)OC(C)C)cc1",
        "output": "539"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.COC(=O)c1c(Cl)cccc1NC(=O)CCCCBr.Cc1ccccc1.c1ccc2nc(N3CCNCC3)ccc2c1>>COC(=O)c1c(Cl)cccc1NC(=O)CCCCN1CCN(c2ccc3ccccc3n2)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1cc(C)c(/C=C/[C@H]2C[C@H](O)CC(=O)O2)c(-c2ccc(F)c(CO[Si](C)(C)C(C)(C)C)c2)c1.Cl.[F-]>>Cc1cc(C)c(/C=C/[C@H]2C[C@H](O)CC(=O)O2)c(-c2ccc(F)c(CO)c2)c1",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)CN.Cl.O=C(O)c1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)c(F)c1>>COC(=O)CNC(=O)c1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)c(F)c1",
        "output": "652"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CN[C@H](CNC2CC2)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1CCC(=O)O.F[P-](F)(F)(F)(F)F>>Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1CCC(=O)N1CCC[C@H]1CNC1CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)OB(c2ccc(N)c(F)c2)OC1(C)C.CCOC(C)=O.CS(=O)(=O)Cl.c1ccncc1>>CC1(C)OB(c2ccc(NS(C)(=O)=O)c(F)c2)OC1(C)C",
        "output": "194"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCOC(C)=O.FC(F)(F)c1cccnc1N1CCc2c(Cl)ncnc2C1.Nc1ccc(S(=O)(=O)C(F)(F)F)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>O=S(=O)(c1ccc(Nc2ncnc3c2CCN(c2ncccc2C(F)(F)F)C3)cc1)C(F)(F)F",
        "output": "352"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)N1CC2CC3N(CSC3(C)C)C2C1.O.O=C([O-])[O-].[K+].[K+]>>CC1(C)SCN2C3CNCC3CC21",
        "output": "283"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.O.[N-]=[N+]=NCc1sc2ccccc2c1-c1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NCc1sc2ccccc2c1-c1ccccc1",
        "output": "89"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COc1cccc2c1CC[C@@H]1NCC[C@H]21.ClCCl.O.O=C(Cl)CC1CCCC1>>COc1cccc2c1CC[C@H]1[C@@H]2CCN1C(=O)CC1CCCC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.C[C@@H]1CNCCN1c1nc(-c2ccncn2)cc(=O)n1C.Cc1nc(-c2ccc(CBr)cc2)no1.O=C([O-])[O-].[K+].[K+]>>Cc1nc(-c2ccc(CN3CCN(c4nc(-c5ccncn5)cc(=O)n4C)[C@H](C)C3)cc2)no1",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN=C=NCCCN(C)C.CCOC(CN1C(=O)C(CC(=O)O)(NC(=O)Nc2ccc(C)cc2)c2ccccc21)OCC.CN(C)c1ccncc1.Cc1ccc(N)cc1.Cl.ClCCl>>CCOC(CN1C(=O)C(CC(=O)Nc2ccc(C)cc2)(NC(=O)Nc2ccc(C)cc2)c2ccccc21)OCC",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COC(=O)CSc1c(C)cc(C(O)(C(F)(F)F)C(F)(F)F)cc1C.Cl.[Na+].[OH-]>>Cc1cc(C(O)(C(F)(F)F)C(F)(F)F)cc(C)c1SCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CCOC(C)=O.CC[C@H](N)c1nc2cccc(F)c2c(=O)n1C1CC1.Cc1nnc(-c2c(N)ncnc2Cl)o1>>CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(F)c2c(=O)n1C1CC1",
        "output": "110"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COCc1csc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(O[C@@H](C)CO[Si](C)(C)C(C)(C)C)c2)n1.ClCCl.O.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>COCc1csc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(O[C@@H](C)CO)c2)n1",
        "output": "708"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.COCCCN1C(=O)C(C)(C)Oc2ccc(N(C(=O)[C@@H]3C[C@H](N)CN(C(=O)OCC4c5ccccc5-c5ccccc54)C3)C3CC3)cc21.Cl.Cl.N#CC1(C(=O)O)CC1.On1nnc2cccnc21>>COCCCN1C(=O)C(C)(C)Oc2ccc(N(C(=O)[C@@H]3C[C@H](NC(=O)C4(C#N)CC4)CN(C(=O)OCC4c5ccccc5-c5ccccc54)C3)C3CC3)cc21",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2ccc([N+](=O)[O-])cc2)CC1.CCO.CO.[H][H].[Pd]>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(N)cc2)CC1",
        "output": "202"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)C(Cc1ccc(Br)cc1)c1ccc(OC)c(N(CC(C)C)C(=O)C(C)(C)C)c1.CO.[Na+].[OH-]>>COc1ccc(C(Cc2ccc(Br)cc2)C(=O)O)cc1N(CC(C)C)C(=O)C(C)(C)C",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2cc(F)cc(F)c2c1Cl.Cc1ccccc1.Nc1cc(N2CCOCC2)cnc1N1CCOCC1>>Cc1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)cnc1N1CCOCC1",
        "output": "859"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.Cl.Fc1ccc(C2CCNCC2)cc1.N#Cc1c(Cl)nc(NCCO)nc1Cl>>N#Cc1c(Cl)nc(NCCO)nc1N1CCC(c2ccc(F)cc2)CC1",
        "output": "162"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.CN(C)C=O.CS(=O)(=O)CCc1ccc(N)cc1F.O=C(Cl)Oc1ccccc1.c1ccncc1>>CS(=O)(=O)CCc1ccc(NC(=O)Oc2ccccc2)cc1F",
        "output": "102"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)Cc1c(C)c(Sc2ccc(NS(=O)(=O)CC)cc2)c2cc(C#N)ccn12.CO.[Na+].[OH-]>>CCS(=O)(=O)Nc1ccc(Sc2c(C)c(CC(=O)O)n3ccc(C#N)cc23)cc1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CC(=O)S[C@@H]1CN2CCC1CC2.CO.[Na+].[OH-]>>S[C@@H]1CN2CCC1CC2",
        "output": "90"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1c[nH]c2ncccc12.CN(C)C=O.O=S(=O)(Cl)c1ccccc1.[H-].[Na+]>>O=S(=O)(c1ccccc1)n1cc(Br)c2cccnc21",
        "output": "354"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)O)c4c3OCC4)nc2N1C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClCCl.F[B-](F)(F)F.N[C@@H]1CC[C@@H](N2CCN(CC3CC3)CC2)CC1.O=C([O-])[O-].[Na+].[Na+]>>CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)N[C@@H]4CC[C@@H](N5CCN(CC6CC6)CC5)CC4)c4c3OCC4)nc2N1C(C)C",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N1CCC(O)(c2ccsc2)C1.ClC(Cl)Cl.O.O=C1CCC(=O)N1Br.O=S([O-])[O-].[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCC(O)(c2ccsc2Br)C1",
        "output": "807"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.COc1ccc(C=O)cc1Cl.[BH4-].[Na+]>>COc1ccc(CO)cc1Cl",
        "output": "356"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)CCNCC1(CO)CCCC1.CO.ClCCl.O.O=C([O-])O.[Na+]>>CC(C)CCN(CC1(CO)CCCC1)C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NCCCCNc1c([N+](=O)[O-])cnc2ccccc12.Cc1ccccc1.[Pt]>>CC(C)(C)OC(=O)NCCCCNc1c(N)cnc2ccccc12",
        "output": "269"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](I)CC[C@@]43C)[C@@H]1CCC2=O.Cc1ccc(S(=O)(=O)O)cc1.OCCO.c1ccccc1>>C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](I)CC[C@@]43C)[C@@H]1CCC21OCCO1",
        "output": "265"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O=C([O-])O.OCCCCCCc1ccccc1.[Na+].c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCCCCCc1ccccc1",
        "output": "193"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCl.Cn1c2c(c3c(Cl)cccc31)C(=O)N(c1ccc3ccn(CC(=O)OC(C)(C)C)c3c1)C2.O=C(O)C(F)(F)F>>Cn1c2c(c3c(Cl)cccc31)C(=O)N(c1ccc3ccn(CC(=O)O)c3c1)C2",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CO.COC(=O)c1ccc2cc3n(c2c1)CC=Cc1ccccc1-3.Cl.F[P-](F)(F)(F)(F)F.O.[Na+].[OH-]>>O=C(O)c1ccc2cc3n(c2c1)CC=Cc1ccccc1-3",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)CC1CCc2c(-c3ccc(C(F)(F)F)c(F)c3)cncc21.O=C(O)CC1CCc2cncc(-c3ccc(C(F)(F)F)c(F)c3)c21>>CNC(=O)CC1CCc2cncc(-c3ccc(C(F)(F)F)c(F)c3)c21",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)[C@H](C)N.COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCC(=O)O.Cl>>COC(=O)[C@H](C)NC(=O)CCCCCOc1c(OC)ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc12",
        "output": "129"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C1=Cc2cc(-c3ccc(C(F)(F)F)cc3)ccc2OCC1.OCCC1CCCO1.[Na+].[OH-]>>O=C(O)C1=Cc2cc(-c3ccc(C(F)(F)F)cc3)ccc2OCC1",
        "output": "122"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCCCCC(=O)NC(CCCc1ccccc1)CCCc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>NCCCCC(=O)NC(CCCc1ccccc1)CCCc1ccccc1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.ClC(Cl)Cl.NCCN1CCOCC1.O.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3cc(C)c(NC(=O)NCCN4CCOCC4)cc3C)c2cc1OC",
        "output": "913"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1ccccc1.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].Oc1ccc(Br)cc1F.[K+].[K+]>>Fc1cc(Br)ccc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(C)=O.ClCCCl.O=C(Cc1cc(F)cc(F)c1)NCC1(c2ccc(I)cc2)CCNCC1.O=CC1CC1.[Na+]>>O=C(Cc1cc(F)cc(F)c1)NCC1(c2ccc(I)cc2)CCN(CC2CC2)CC1",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCNCCCC.CCc1sc(-c2ccccc2)nc1-c1ccc(OCCCCl)cc1.NC(=S)c1ccccc1>>CCCCN(CCCC)CCCOc1ccc(-c2nc(-c3ccccc3)sc2CC)cc1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Oc1ccc(C2=CCC(=O)CC2)cc1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>O=C1CC=C(c2ccc(O)cc2)CC1",
        "output": "754"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCO.CCOC(=O)C1CC(=O)NC1(C)C.CCOC(=O)CC(C(=O)OCC)C(C)(C)[N+](=O)[O-].COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1ccccc1.[H][H].[Pd]>>CCOC(=O)C1CC(=S)NC1(C)C",
        "output": "695"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)C[C@@H](c1ccc(OCc2ccc(C(C)(C)C)c(-c3cc(OC)ccc3F)c2)cc1)C1CC1.[Li+].[OH-]>>COc1ccc(F)c(-c2cc(COc3ccc([C@@H](CC(=O)O)C4CC4)cc3)ccc2C(C)(C)C)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-n3ccnn3)c2)cc1Cl.ClCCl.O=C(O)C(F)(F)F>>CC(C)CN(C)c1cc2c(cc1Cl)NC(=O)CC(c1cccc(-n3ccnn3)c1)=N2",
        "output": "930"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.COc1ccc2nc(Cl)c(C=O)cc2c1.ClCCl>>O=Cc1cc2cc(O)ccc2nc1Cl",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=S(=O)(Nc1ccc(F)c(-c2nc(N3CCOCC3)sc2-c2ccnc(Cl)n2)c1F)c1c(F)cccc1F.[NH4+].[OH-]>>Nc1nccc(-c2sc(N3CCOCC3)nc2-c2c(F)ccc(NS(=O)(=O)c3c(F)cccc3F)c2F)n1",
        "output": "312"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC=Cc1c(C(C)C)nc(C(C)C)c(C(=O)OCC)c1-c1ccc(Cl)cc1Cl.CCCCCC.CCOC(C)=O>>CCCC=Cc1c(C(C)C)nc(C(C)C)c(CO)c1-c1ccc(Cl)cc1Cl",
        "output": "383"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc2c(-c3cnc4[nH]cc(C(=O)NC5(C)CCN(C(=O)OC(C)(C)C)C5)c4n3)nn(C)c2c1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>Cc1ccc2c(-c3cnc4[nH]cc(C(=O)NC5(C)CCNC5)c4n3)nn(C)c2c1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CC(C)=O.COC(=O)Cc1cc(Br)cc(Br)c1O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>COC(=O)Cc1cc(Br)cc(Br)c1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=[N+]([O-])c1cnc2c(c1)OCC(CO)N2.[Pd]>>Nc1cnc2c(c1)OCC(CO)N2",
        "output": "269"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.CCc1cc(C(=O)c2c(Cc3ccccc3)oc(C)c2C)cc(CC)c1OC.ClCCl.ClCCl>>CCc1cc(C(=O)c2c(Cc3ccccc3)oc(C)c2C)cc(CC)c1O",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNS(=O)(=O)c1cccc(CCCC(CCc2ccccc2)C(=O)O)c1.CO.O.O=S(=O)(O)O>>CNS(=O)(=O)c1cccc(CCCC(CCc2ccccc2)C(=O)OC)c1",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=[N+]=[N-].CCOC(C)=O.O=C(O)c1cccnc1Cl>>COC(=O)c1cccnc1Cl",
        "output": "60"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCC.CCCCCCC#Cc1ccc2ccc(OC)cc2c1.Cc1ccccc1.[Pd]>>CCCCCCCCc1ccc2ccc(OC)cc2c1",
        "output": "717"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.ClCCl.NCCc1c[nH]c(=S)n1[C@H]1COc2c(F)cc(F)cc2C1.O=Cc1ccccc1>>Fc1cc(F)c2c(c1)C[C@@H](n1c(CCNCc3ccccc3)c[nH]c1=S)CO2",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=Cc1cc(CC(C(=O)OCC)C(=O)OCC)cnc1NC(=O)OC(C)(C)C.CCO.ClCCl.[K+].[OH-]>>C=Cc1cc(CC(C(=O)O)C(=O)OCC)cnc1NC(=O)OC(C)(C)C",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.CCOC(=O)Cc1ccc(Nc2cc(Cl)nc3c2CCC3)cc1>>CCOC(=O)Cc1ccc(Nc2cc(N3CCOCC3)nc3c2CCC3)cc1",
        "output": "220"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCN(c2cc(F)ccc2[N+](=O)[O-])CC1.CCN(C(C)C)C(C)C.NCc1cccc(Cl)c1>>CC(C)(C)OC(=O)N1CCN(c2cc(NCc3cccc(Cl)c3)ccc2[N+](=O)[O-])CC1",
        "output": "764"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOCC.CN(C)C=O.O=C(CCCO)c1ccccc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCCC(=O)c1ccccc1",
        "output": "193"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cl.N#Cc1ccc(N)cc1.O.S=C(Cl)Cl>>N#Cc1ccc(N=C=S)cc1",
        "output": "114"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.CC[Si](C#CCOCC1CCC2(CC1)OCCO2)(CC)CC.Cl>>CC[Si](C#CCOCC1CCC(=O)CC1)(CC)CC",
        "output": "251"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.CN1CCN(S(=O)(=O)c2c(Cl)ccc(Nc3c(Cl)c(=O)c3=O)c2O)CC1.Nc1ccc(F)cc1F.c1ccc(-c2ccccc2)cc1>>CN1CCN(S(=O)(=O)c2c(Cl)ccc(Nc3c(Nc4ccc(F)cc4F)c(=O)c3=O)c2O)CC1",
        "output": "510"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](CN)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1cc(C(=O)O)cc(Cl)n1.F[B-](F)(F)F.O>>COc1cc(C(=O)NC[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)cc(Cl)n1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1c(C)cc(C(=O)O)cc1C.O>>COC(=O)c1cc(C)c(OC)c(C)c1",
        "output": "33"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.COCc1ccc(C(=O)O)c(N)n1.COc1ccccc1Oc1cccc(CN)c1.F[P-](F)(F)(F)(F)F.O>>COCc1ccc(C(=O)NCc2cccc(Oc3ccccc3OC)c2)c(N)n1",
        "output": "790"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN.Cl.ClCCl.O=C([O-])O.O=Cc1cc(Cl)ccc1[N+](=O)[O-].[BH4-].[Na+].[Na+]>>CNCc1cc(Cl)ccc1[N+](=O)[O-]",
        "output": "468"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.ClCCl.NC[C@H]1CN(c2ccc(N3CCC4(CC3)OCCO4)c(F)c2)C(=O)O1.O=C(O)C(Cl)Cl>>O=C(NC[C@H]1CN(c2ccc(N3CCC4(CC3)OCCO4)c(F)c2)C(=O)O1)C(Cl)Cl",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)CN(CC(O)C(Cc1ccccc1)NC(=O)OC1COC2OCCC12)S(=O)(=O)c1ccc([N+](=O)[O-])c(NC2CCN(C3CCCC3)C2)c1.CC1CCCO1.O=C[O-].[NH4+].[Pd]>>CC(C)CN(CC(O)C(Cc1ccccc1)NC(=O)OC1COC2OCCC12)S(=O)(=O)c1ccc(N)c(NC2CCN(C3CCCC3)C2)c1",
        "output": "401"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CN(C)C=O.CO.COP(=O)(CCc1cccc2c1O[C@H]1C[C@@H](O)[C@H](CO)[C@@H]21)OC.Cl.ClC(c1ccccc1)(c1ccccc1)c1ccccc1.O.O=C([O-])O.[Na+]>>COP(=O)(CCc1cccc2c1O[C@H]1C[C@@H](OC(C)=O)[C@H](CO)[C@@H]21)OC",
        "output": "254"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cn1c(CCc2ccc(C#N)cc2)nc2cc(N)ccc21.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>Cn1c(CCc2ccc(C#N)cc2)nc2cc(NC(=O)C(F)(F)F)ccc21",
        "output": "106"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(Oc2cccc(C(=O)O)c2)cc1.N[C@H]1CO[C@@H]2[C@@H](NC(=O)C3CC3)CO[C@H]12>>COc1ccc(Oc2cccc(C(=O)N[C@H]3CO[C@@H]4[C@@H](NC(=O)C5CC5)CO[C@H]34)c2)cc1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.Cc1cc(OCCCO)cc(OS(=O)(=O)c2cc(C)ccc2C#N)c1.ClCCl>>Cc1cc(OCCC=O)cc(OS(=O)(=O)c2cc(C)ccc2C#N)c1",
        "output": "142"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(N=C=O)cc1N1C(=O)c2ccc(Cl)cc2C1=O.OCc1ccccc1>>Cc1ccc(NC(=O)OCc2ccccc2)cc1N1C(=O)c2ccc(Cl)cc2C1=O",
        "output": "34"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CO.COc1cc(N)c([N+](=O)[O-])cc1Br.[Zn]>>COc1cc(N)c(N)cc1Br",
        "output": "202"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.CN1CCOCC1.Cc1ccc(-c2cc(C(=O)O)cc(-c3ccnn3CC3CC3)c2)nc1.Cc1cnc(CN)cn1.ClCCl.On1nnc2ccccc21>>Cc1ccc(-c2cc(C(=O)NCc3cnc(C)cn3)cc(-c3ccnn3CC3CC3)c2)nc1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCOC(=O)C1CCNCC1.CS(C)=O.FC(F)(F)c1ccc(Cl)nc1>>CCOC(=O)C1CCN(c2ccc(C(F)(F)F)cn2)CC1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrC(Br)(Br)Br.C1CCOC1.CC(C)(C)OC(=O)N1CCC[C@H]1/C=C/c1ccc(CO)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCC[C@H]1/C=C/c1ccc(CBr)cc1",
        "output": "750"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C#N)c1cccc(C(=O)O)c1.CCO.O.OO.[Li]O>>CC(C)(C(N)=O)c1cccc(C(=O)O)c1",
        "output": "632"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(OCC)P(=O)(CC(C#N)Cc1ccccc1)OCC.N.[H][H].[Ni]>>CCOC(OCC)P(=O)(CC(CN)Cc1ccccc1)OCC",
        "output": "246"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1c2n(c3c(Br)cc(C#N)cc13)CCNC2=O.OB(O)c1cc(F)cc(F)c1>>Cc1c2n(c3c(-c4cc(F)cc(F)c4)cc(C#N)cc13)CCNC2=O",
        "output": "833"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CCNCC2)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN1CCCC1=O.F[P-](F)(F)(F)(F)F.O.O=C(O)c1ccccc1>>CC(C)(C)OC(=O)N1CCC2(CC1)CCN(C(=O)c1ccccc1)CC2",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C1CCC(=O)CC1.Cn1nc(NCC(=O)NC2CNC2)c2cc(C(F)(F)F)ccc21.O=C(O)C(F)(F)F>>CCOC(=O)C1CCC(N2CC(NC(=O)CNc3nn(C)c4ccc(C(F)(F)F)cc34)C2)CC1",
        "output": "187"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNCC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.ClCCCl.ClCCl.NC(=O)c1ccc(Oc2ccc(C=O)cc2)nc1.[Na+]>>NC(=O)c1ccc(Oc2ccc(CN3CCCCC3)cc2)nc1",
        "output": "567"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN.O=CC1(c2ccc(F)c(Cl)c2)CCCCC1>>CNCC1(c2ccc(F)c(Cl)c2)CCCCC1",
        "output": "426"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(CNC(=O)C2CC2)ccc1Cl.[Na+].[OH-]>>O=C(O)c1cc(CNC(=O)C2CC2)ccc1Cl",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(CC)CC.CNOC.Cl.O.O=C(Cl)C(=O)Cl.O=C(O)c1cncc(Br)c1>>CON(C)C(=O)c1cncc(Br)c1",
        "output": "879"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNC1.O=C(O)c1cccc(Br)n1>>O=C(c1cccc(Br)n1)N1CCCC1",
        "output": "605"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(CC)c1ccc(Cl)c2nc(Cl)n(C)c12.CN(C)C=O.O.O=C([O-])[O-].Oc1c(Cl)cc(Cl)cc1Br.[K+].[K+]>>CCC(CC)c1ccc(Cl)c2nc(Oc3c(Cl)cc(Cl)cc3Br)n(C)c12",
        "output": "542"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Cl.Cc1cc(CN)c(Cc2nc3cc(C#N)ccc3[nH]2)c2cc[nH]c12.ClCCl.O=C([O-])O.[Na+]>>CC(=O)NCc1cc(C)c2[nH]ccc2c1Cc1nc2cc(C#N)ccc2[nH]1",
        "output": "206"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.COC(=O)c1ccc(CN2CC3CN(Cc4ccc(Oc5nc6ccccc6s5)cc4)CC3C2)cc1.Cl.ClCCl.O.[K+].[OH-]>>O=C(O)c1ccc(CN2CC3CN(Cc4ccc(Oc5nc6ccccc6s5)cc4)CC3C2)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCOC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4C(=O)OC(C)(C)C)cc3)c2c1.O=C(O)C(F)(F)F>>CCCCCCOC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1",
        "output": "752"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1c(CC(NC(=O)CCc2cncs2)B2OC3CC4CC(C4(C)C)C3(C)O2)cccc1C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>COc1c(CC(NC(=O)CCc2cncs2)B2OC3CC4CC(C4(C)C)C3(C)O2)cccc1C(=O)O",
        "output": "752"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)O.CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.c1c[nH]cn1>>CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@H](C[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)O)O[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)OC(C)C.CCCCO.O=C(O)CCc1ccccc1.[Zn]>>CCCCOC(=O)CCc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrC(Br)(Br)Br.C1CCNC1.COc1cc(OC)c2c(=O)[nH]c(-c3ncc(OCCO)cc3NC3CCN(C(C)C)CC3)nc2c1.ClC(Cl)Cl.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc(OC)c2c(=O)[nH]c(-c3ncc(OCCN4CCCC4)cc3NC3CCN(C(C)C)CC3)nc2c1",
        "output": "371"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1ccc(C(C(=O)Nc2cccc3cccnc23)C(=O)Nc2cccc3cccnc23)cc1.O.O.[Li]O>>O=C(O)c1ccc(C(C(=O)Nc2cccc3cccnc23)C(=O)Nc2cccc3cccnc23)cc1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CO.COc1ccc(CN2CCC(N3CC=C(c4ccc(OC)cc4)CC3)C2=O)cc1>>COc1ccc(CN2CCC(N3CCC(c4ccc(OC)cc4)CC3)C2=O)cc1",
        "output": "806"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CN(C)C=O.Cc1cc(C#N)ccc1C(=O)O.Nc1cccnc1.O=C(Cl)C(=O)Cl>>Cc1cc(C#N)ccc1C(=O)Nc1cccnc1",
        "output": "759"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCO.CNC.CO.Cc1c[n+]([O-])c(N[C@H]2CC[C@@H](NCc3ccccc3)CC2)cc1Cl.ClC(Cl)Cl.O=C([O-])O.[Na+]>>Cc1c[n+]([O-])c(N[C@H]2CC[C@@H](NCc3ccccc3)CC2)cc1N(C)C",
        "output": "398"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OB(c2ccc(S(=O)(=O)NCCO)cc2)OC1(C)C.COc1ccc2[nH]c(=O)c3c(c2c1Br)CCC3>>COc1ccc2[nH]c(=O)c3c(c2c1-c1ccc(S(=O)(=O)NCCO)cc1)CCC3",
        "output": "972"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCNC(=O)Nc1ccc(Oc2ccnc3cc(OCc4ccccc4)c(C#N)cc23)cc1C.[C].[Pd]>>CCNC(=O)Nc1ccc(Oc2ccnc3cc(O)c(C#N)cc23)cc1C",
        "output": "23"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNC1.C1CSCN1.O=C(CC1CCc2ccccc21)C1SCN[C@@H]1C(=O)O.O=C(O)[C@@H]1CCCN1C(=O)CC1CCc2ccccc2C1>>O=C([C@@H]1CCCN1C(=O)CC1CCc2ccccc2C1)N1CCCC1",
        "output": "685"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCN=C=O.C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)NC3CC3)cc2)nc2c1CNC2>>CCNC(=O)N1Cc2nc(-c3ccc(NC(=O)NC4CC4)cc3)nc(N3CCOC[C@@H]3C)c2C1",
        "output": "437"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CNC(C)(C)C.O=C(Cl)c1ccccc1>>CN(C(=O)c1ccccc1)C(C)(C)C",
        "output": "201"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1cc(-c2ccc(N)cc2)c2c(N)ncnn12.CCN(CC)CC.CN(C)C=O.CS(C)=O.O=C(Nc1cccc(C(F)(F)F)n1)Oc1ccccc1>>CC(=O)c1cc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)n3)cc2)c2c(N)ncnn12",
        "output": "948"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(O)Cn1ccc(N)n1.CCN=C=NCCCN(C)C.COc1cccc(OC2=CC(=O)N([C@@H](CC(C)C)C(=O)O)C2)c1Cl.ClCCl.On1nnc2ccccc21>>COc1cccc(OC2=CC(=O)N([C@@H](CC(C)C)C(=O)Nc3ccn(CC(C)(C)O)n3)C2)c1Cl",
        "output": "795"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1nn(-c2ccccc2)cc1[N+](=O)[O-].Cl.[Na+].[OH-]>>O=C(O)c1nn(-c2ccccc2)cc1[N+](=O)[O-]",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COCC1(CNC(=O)OC(C)(C)C)CCN(Cc2ccccc2)C1.[C].[Pd]>>COCC1(CNC(=O)OC(C)(C)C)CCNC1",
        "output": "84"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COC(C)(C)C.O=C([O-])[O-].O=[N+]([O-])c1cc(F)c(F)cc1F.Oc1ccnc(Cl)c1.[K+].[K+]>>O=[N+]([O-])c1cc(F)c(Oc2ccnc(Cl)c2)cc1F",
        "output": "564"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=C[C@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1O.CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.ClCCl.c1c[nH]cn1>>C=C[C@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C",
        "output": "602"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CO.OC1CNCCN(c2nc(I)ccc2Br)C1>>CC(C)(C)OC(=O)N1CCN(c2nc(I)ccc2Br)CC(O)C1",
        "output": "694"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cn(C(Cc2cocn2)C(=O)OC(C)(C)C)c(=O)cc1-c1cc(Cl)ccc1C#N.ClCCl.O=C(O)C(F)(F)F>>COc1cn(C(Cc2cocn2)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1C#N",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CCO.CO.O=C(O)COc1cccc([N+](=O)[O-])c1.[Pd]>>Nc1cccc(OCC(=O)O)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CCOC(=O)Nc1cc(-c2ccc(=O)n(C(C)C)n2)c(-c2ccccc2)nc1CO.CCOC(C)=O.CO.c1ccncc1>>CCOC(=O)Nc1cc(-c2ccc(=O)n(C(C)C)n2)c(-c2ccccc2)nc1COC(C)=O",
        "output": "254"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CNCC(C)C.C[C@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.ClCCl.O.On1nnc2ccccc21>>CC(C)CN(C)C(=O)[C@@H](NC(=O)OC(C)(C)C)[C@H](C)O",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc2nc(-c3ccc(OC(C)=O)cc3)n(C)c(=O)c2c1.N>>COc1ccc2nc(-c3ccc(O)cc3)n(C)c(=O)c2c1",
        "output": "22"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.O=C([O-])c1ccc2nc3n(c(=O)c2c1)CCC3.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>O=c1c2cc(CO)ccc2nc2n1CCC2",
        "output": "72"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc2onc(OCc3ncccn3)c2c1.CCOC(C)=O.CN(C)C=O.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccc(OC(F)(F)F)cc1.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>FC(F)(F)Oc1ccc(-c2ccc3onc(OCc4ncccn4)c3c2)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CCO.COC(=O)Cn1cc(C#N)c(-c2cc([N+](=O)[O-])cc(C(F)(F)F)c2)c1.[Fe]>>COC(=O)Cn1cc(C#N)c(-c2cc(N)cc(C(F)(F)F)c2)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.C[C@]12CCC3=C(CCc4cc(O)ccc43)C1=CCC2=O.c1ccncc1>>CC(=O)Oc1ccc2c(c1)CCC1=C2CC[C@]2(C)C(=O)CC=C12",
        "output": "46"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.NN.O.O=C1CN(C(=O)NC(CN2C(=O)c3ccccc3C2=O)c2ccc(OC(F)(F)F)cc2)c2ncccc2N1>>NCC(NC(=O)N1CC(=O)Nc2cccnc21)c1ccc(OC(F)(F)F)cc1",
        "output": "242"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC(CO)C1.CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCN(C(C)C)C(C)C.CN(C)c1ccncc1.ClCCl>>CC(C)(C)OC(=O)N1CC(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C1",
        "output": "602"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)c1cc([N+](=O)[O-])cc2ccccc12.ClCCl.[Pd]>>COC(=O)c1cc(N)cc2ccccc12",
        "output": "481"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CO.COCC(=O)Nc1cc(Oc2ccc([N+](=O)[O-])c(S(C)(=O)=O)c2)ccn1.ClCCl.[H][H].[Pd]>>COCC(=O)Nc1cc(Oc2ccc(N)c(S(C)(=O)=O)c2)ccn1",
        "output": "335"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)C(C)Oc1ccc(OC(C)=O)cc1.Cl>>CCOC(=O)C(C)Oc1ccc(O)cc1",
        "output": "22"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(C)c1ccc(C(=O)Cl)cc1.CCN(C(C)C)C(C)C.Nc1cccc(Br)c1Br>>CC(C)(C)c1ccc(C(=O)Nc2cccc(Br)c2Br)cc1",
        "output": "11"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(COC1CCCCO1)c1cc(NC(=O)[C@@H]2CCN2c2ncc(C(F)(F)F)cc2Cl)on1.CCO.Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1>>CC(C)(CO)c1cc(NC(=O)[C@@H]2CCN2c2ncc(C(F)(F)F)cc2Cl)on1",
        "output": "543"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CNOC.Cl.Cl.O=C(O)c1cccc2[nH]cnc12>>CON(C)C(=O)c1cccc2[nH]cnc12",
        "output": "879"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COc1cc(C(=O)O)c2ccn(C(C)C)c2c1.O=S(=O)(O)O>>COC(=O)c1cc(OC)cc2c1ccn2C(C)C",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.Cc1oc(-c2ccccc2)nc1CCO.O=C([O-])O.O=C1CCC(=O)N1Br.[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1oc(-c2ccccc2)nc1CCBr",
        "output": "581"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCS.CN(C)C=O.COc1ccc(C(CC(=O)O)CC(=O)O)cc1.[Na]>>O=C(O)CC(CC(=O)O)c1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCCOCCc1ccc(F)cc1F>>CS(=O)(=O)OCCOCCc1ccc(F)cc1F",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CNC[C@H](CNC2CC2)C1.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)O.On1nnc2ccccc21>>Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H](CNC2CC2)C1",
        "output": "256"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COc1cc(Nc2cncc(-c3ccc(O)cc3)n2)c(Cl)cc1C(=O)O.F[B-](F)(F)F.NC1CCN(Cc2ccccc2)CC1>>COc1cc(Nc2cncc(-c3ccc(O)cc3)n2)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCOC(C)=O.COC(=O)CCCCCNc1ncnc2oc(-c3ccccc3C(F)(F)F)c(-c3ccc(OC)cc3)c12.Cl.[Na+].[OH-]>>COc1ccc(-c2c(-c3ccccc3C(F)(F)F)oc3ncnc(NCCCCCC(=O)O)c23)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccc(F)c(F)c1)C(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.Cl.ClC(Cl)Cl.ClCCl.NCc1ccc(N)nc1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(F)c(F)c1)C(=O)NCc1ccc(N)nc1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(CC#N)[C@@H]1O[C@@H](C)[C@@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1.CCO.O.[Na+].[OH-]>>CC(CC(=O)O)[C@@H]1O[C@@H](C)[C@@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1",
        "output": "259"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CNC.Cc1cc(Br)ccc1C(=O)O.ClCCl.O=C(Cl)C(=O)Cl>>Cc1cc(Br)ccc1C(=O)N(C)C",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "FC1(CBr)COC1.O=C1OC2(CCN(C(=O)c3c[nH]c4cc(Cl)ccc34)CC2)c2ccc(F)cc21>>O=C1OC2(CCN(C(=O)c3cn(CC4(F)COC4)c4cc(Cl)ccc34)CC2)c2ccc(F)cc21",
        "output": "470"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)I.CCO.O.O=C(O)c1cc(F)c(F)c(O)c1F.[Na+].[OH-]>>CC(C)Oc1c(F)c(F)cc(C(=O)O)c1F",
        "output": "318"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Clc1ccnc(Cl)n1.O=C([O-])O.O=C([O-])[O-].O=[N+]([O-])c1ccc(O)c(F)c1.[K+].[K+].[Na+]>>O=[N+]([O-])c1ccc(Oc2ccnc(Cl)n2)c(F)c1",
        "output": "668"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCC(=O)Cl.CCCN(CCC)CCc1ccc(N)c(OCc2ccccc2)c1.CCN(CC)CC.O>>CCCC(=O)Nc1ccc(CCN(CCC)CCC)cc1OCc1ccccc1",
        "output": "9"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCCn1c(NC2CCN(CCC3(c4ccccc4)CCNC3)CC2)nc2ccccc21.COc1ccc(CS(C)=O)cc1C(=O)O.Cl>>CCOCCn1c(NC2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(CS(C)=O)ccc4OC)C3)CC2)nc2ccccc21",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCc1cc(F)c2cccnc2c1O.CO.[H][H].[Pd]>>CCCc1cc(F)c2cccnc2c1O",
        "output": "116"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1=C(c2ccc(F)cc2)c2ccc(N)cc2OC1(C)C.CS(=O)(=O)Cl.ClC(Cl)Cl.c1ccncc1>>CC1=C(c2ccc(F)cc2)c2ccc(NS(C)(=O)=O)cc2OC1(C)C",
        "output": "194"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)=O.CCCCOc1ccc(Cl)cc1C(=O)Cl.CCOC(=O)Cc1ccc(CCN)cc1.Cl.c1ccncc1>>CCCCOc1ccc(Cl)cc1C(=O)NCCc1ccc(CC(=O)OCC)cc1",
        "output": "271"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Cl.ClCCN1CCOCC1.Cn1c(=O)c2c(ncn2Cc2ccc(C(=O)c3ccc(O)cc3)cc2)n(C)c1=O.O.O=C([O-])[O-].[K+].[K+]>>Cn1c(=O)c2c(ncn2Cc2ccc(C(=O)c3ccc(OCCN4CCOCC4)cc3)cc2)n(C)c1=O",
        "output": "74"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)C=O.NC1CNc2c(cc(Br)cc2[N+](=O)[O-])C1.O>>CC(C)(C)OC(=O)NC1CNc2c(cc(Br)cc2[N+](=O)[O-])C1",
        "output": "631"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)CN.CCCCO.Nc1nc(Cl)nc2c1ncn2Cc1ccccc1.[Na+].[OH-]>>CC(C)(C)CNc1nc(N)c2ncn(Cc3ccccc3)c2n1",
        "output": "578"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)c1cc(Cl)ncc1C(=O)NCc1ccc(F)cc1.CO.CS(=O)(=O)O.Nc1cccc(C(F)(F)F)c1>>CC(C)c1cc(Nc2cccc(C(F)(F)F)c2)ncc1C(=O)NCc1ccc(F)cc1",
        "output": "434"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.FC(F)(F)c1cccc2c(Cl)ccnc12.Nc1ccc(C(=O)O)cc1.O>>O=C(O)c1ccc(Nc2ccnc3c(C(F)(F)F)cccc23)cc1",
        "output": "115"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.Cc1cccnc1CN(Cc1ncccc1C)C1CCNCC1.O.O.O=C(O)c1c[nH]cn1.[Cl-].[Na+]>>Cc1cccnc1CN(Cc1ncccc1C)C1CCN(C(=O)c2c[nH]cn2)CC1",
        "output": "729"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2oc3ccc(Br)cc3c2C)C2CCCCC2)cc1.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2oc3ccc(-c4cnn(C)c4)cc3c2C)C2CCCCC2)cc1",
        "output": "971"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.NC(=O)c1cc(-c2ccccc2)cc2c(C3CCN(S(=O)(=O)CCCCl)CC3)n[nH]c12.NC1CCC1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>NC(=O)c1cc(-c2ccccc2)cc2c(C3CCN(S(=O)(=O)CCCNC4CCC4)CC3)n[nH]c12",
        "output": "279"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cc2cc(OCc3ccccc3)ccc2n1C(=O)OC(C)(C)C.O=C[O-].[NH4+].[Pd]>>CCOC(=O)c1cc2cc(O)ccc2n1C(=O)OC(C)(C)C",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOc1ccc(-c2nc3ccccn3c2-c2ccnc(Cl)n2)cc1C(=O)Nc1c(F)cccc1F.CO.COCCN1CCN(c2cc(OC)c(N)cc2C)CC1.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.N.OCC(F)(F)F>>CCOc1ccc(-c2nc3ccccn3c2-c2ccnc(Nc3cc(C)c(N4CCN(CCOC)CC4)cc3OC)n2)cc1C(=O)Nc1c(F)cccc1F",
        "output": "808"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[Si](C)(C)Oc1ccc(O)cc1.CCCCP(CCCC)CCCC.CCOC(C)=O.CN(C)C(=O)N=NC(=O)N(C)C.Cc1ccccc1.OCCOCCOCCOCCOCCOC(c1ccccc1)(c1ccccc1)c1ccccc1>>CC(C)(C)[Si](C)(C)Oc1ccc(OCCOCCOCCOCCOCCOC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1",
        "output": "478"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCO.CCN(CC)CC.CCOCC.COc1cc2nc(Cl)nc(N)c2cc1OCc1ccccc1.Cl.O=C(N1CCCNCC1)N1CCOCC1>>COc1cc2nc(N3CCCN(C(=O)N4CCOCC4)CC3)nc(N)c2cc1OCc1ccccc1",
        "output": "36"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC[SiH](CC)CC.ClCCl.O=C(O)C(F)(F)F.Oc1ccc2c(c1)OC(c1ccccc1)CC2O>>Oc1ccc2c(c1)OC(c1ccccc1)CC2",
        "output": "447"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1.OCCOCCOCCOCCO.c1ccncc1>>COc1ccc(C(OCCOCCOCCOCCO)(c2ccccc2)c2ccc(OC)cc2)cc1",
        "output": "250"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCc1cc(Br)c2ncccc2c1.O=[N+]([O-])c1cccc(B(O)O)c1>>CCCc1cc(-c2cccc([N+](=O)[O-])c2)c2ncccc2c1",
        "output": "833"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)c1c(C)n(Cc2c(F)cccc2F)c(C)c(Br)c1=O.COCCOC.COc1cccc(B(O)O)c1F.[Ba+2].[OH-].[OH-].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccccc1>>CCOC(=O)c1c(C)n(Cc2c(F)cccc2F)c(C)c(-c2cccc(OC)c2F)c1=O",
        "output": "833"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.OCCOCC(F)(F)F>>Cc1ccc(S(=O)(=O)OCCOCC(F)(F)F)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCN(CC)c1nc2ccc(O[Si](C)(C)C(C)(C)C)cc2c(=O)n1NC(=O)Cc1cc(F)cc(F)c1.[F-]>>CCN(CC)c1nc2ccc(O)cc2c(=O)n1NC(=O)Cc1cc(F)cc(F)c1",
        "output": "754"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CCO.CCOC(C)=O.Cl.NO.O.O=C1CCCC(C(F)(F)F)C1.[Na+]>>ON=C1CCCC(C(F)(F)F)C1",
        "output": "86"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.COC(=O)c1cn2c3c(c(Cl)ccc3c1=O)CCN2C.Cl>>CN1CCc2c(Cl)ccc3c(=O)c(C(=O)O)cn1c23",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1nc2n(c(=O)c1CCCl)CCCC2.Cl.Cl.Fc1ccc2c(C3CCNCC3)noc2c1.O.O=C([O-])[O-].[Na+].[Na+]>>Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.CS(=O)(=O)c1ccc2c(c1)cc(C1CCCO1)n2S(=O)(=O)c1ccccc1.O.[K+].[OH-]>>CS(=O)(=O)c1ccc2[nH]c(C3CCCO3)cc2c1",
        "output": "771"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=CC[C@H](OC(c1ccccc1)(c1ccccc1)c1ccc(OC)cc1)[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@H](OC)[C@@H]1O[Si](C)(C)C(C)(C)C>>C=CC[C@H](OC(c1ccccc1)(c1ccccc1)c1ccc(OC)cc1)[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@H](OC)[C@@H]1O",
        "output": "708"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cc(F)c(Br)cc1C(=O)O>>CCNC(=O)c1cc(Br)c(F)cc1N",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)c1ccncc1.Cc1cc(O)ccc1-c1cscn1.Cc1cccc(C)n1.ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1cc(OS(=O)(=O)C(F)(F)F)ccc1-c1cscn1",
        "output": "731"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(Oc1ccccc1)C(=O)O.CCN=C=NCCCN(C)C.Cl.ClCCl.Nc1cccc(-c2nn(C3CCCCO3)c3ccc(-c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1>>CC(Oc1ccccc1)C(=O)Nc1cccc(-c2nn(C3CCCCO3)c3ccc(-c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1",
        "output": "365"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.Cc1cc(-c2ccccc2)n[nH]c1=O.Cl.O=P(Cl)(Cl)Cl.O=P(O)(O)O>>Cc1cc(-c2ccccc2)nnc1Cl",
        "output": "537"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)C=O.ClCCl.N[C@@H]1CCCN2c3cc(Cl)ccc3Oc3ccccc3[C@H]12.[Na+]>>CC(C)CN[C@@H]1CCCN2c3cc(Cl)ccc3Oc3ccccc3[C@H]12",
        "output": "426"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2cccc(CO)n2)CC1.CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)N1CCC(c2cccc(COS(C)(=O)=O)n2)CC1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCC1CC1.C1CCOC1.CCOC(C)=O.CN(C)C=O.CN(CCO)c1ccc([N+](=O)[O-])cn1.[H-].[Na+]>>CN(CCOCC1CC1)c1ccc([N+](=O)[O-])cn1",
        "output": "95"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C1(CCOC)CCNCC1.O=S(=O)(Cl)c1ccccc1>>CCOC(=O)C1(CCOC)CCN(S(=O)(=O)c2ccccc2)CC1",
        "output": "99"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCc1ccccc1.CC(C)=O.CCc1cc(C=O)cc(C)c1O.O=C([O-])[O-].[K+].[K+]>>CCc1cc(C=O)cc(C)c1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(C)=O.NC(=O)c1c(Cl)ccc(Nc2c(Cl)c(=O)c2=O)c1O.Nc1ccccc1>>NC(=O)c1c(Cl)ccc(Nc2c(Nc3ccccc3)c(=O)c2=O)c1O",
        "output": "510"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cc(CC2c3cc(OC)c(OC)cc3CCN2CC(=O)NCc2ccccc2)ccc1O.O=C(Cl)N1CCOCC1>>COc1cc2c(cc1OC)C(Cc1ccc(OC(=O)N3CCOCC3)c(OC)c1)N(CC(=O)NCc1ccccc1)CC2",
        "output": "425"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC[N+](CCC)(CCC)CCC.COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H]2C[C@H]2CO)c(F)c1.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-]>>COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H]2C[C@H]2C=O)c(F)c1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(-c2cc(C(F)(F)F)n[nH]2)cc1.Ic1ccccc1>>Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccccc2)cc1",
        "output": "901"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cncc(OC(=O)N2CCC(CCc3cccc(C#N)c3)CC2)c1.Cl.O.[Na+].[OH-]>>N#Cc1cccc(CCC2CCN(C(=O)Oc3cncc(C(=O)O)c3)CC2)c1",
        "output": "152"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Cl.O.O=C(OCc1ccccc1)c1cc(C(F)(F)F)c(C(=O)N2CCCCC2)cc1OCc1ccccc1.[Li+].[OH-]>>O=C(O)c1cc(C(F)(F)F)c(C(=O)N2CCCCC2)cc1OCc1ccccc1",
        "output": "290"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[SiH2]OC(C)(C)c1cc(CO)cc([N+](=O)[O-])c1.CCO.[Pd]>>CC(C)(C)[SiH2]OC(C)(C)c1cc(N)cc(CO)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN.CN(C)C=O.COc1ccc(Sc2ccc(Sc3nncn3C)nc2C(=O)Nc2ncc(SCC(=O)O)s2)cc1.Cl.O.On1nnc2ccccc21>>CNC(=O)CSc1cnc(NC(=O)c2nc(Sc3nncn3C)ccc2Sc2ccc(OC)cc2)s1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)c1ccc2c(=O)[nH]ccc2c1.CS(C)=O.Cc1c(Br)cccc1Br.O=C([O-])[O-].[K+].[K+]>>Cc1c(Br)cccc1-n1ccc2cc(N(C)C)ccc2c1=O",
        "output": "349"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1CCCC[C@@H](Oc1ccc(C(F)(F)F)cc1)c1ccccc1>>NCCCC[C@@H](Oc1ccc(C(F)(F)F)cc1)c1ccccc1",
        "output": "242"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COCCCN1CCOc2ccc(COC3CN(C(=O)OCc4ccccc4)CCC3c3ccc(OC4CCNC4)cc3)cc21.ClCCl.O=C(Cl)CC1CC1>>COCCCN1CCOc2ccc(COC3CN(C(=O)OCc4ccccc4)CCC3c3ccc(OC4CCN(C(=O)CC5CC5)C4)cc3)cc21",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.C1CCOC1.CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNc1ccc(O)cc1.c1ccncc1>>CN(C(=O)OC(C)(C)C)c1ccc(O)cc1",
        "output": "827"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)I.CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1cc(F)c(O)cc1F.[K+].[K+]>>CC(C)Oc1cc(F)c([N+](=O)[O-])cc1F",
        "output": "318"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)[C@@H](N)Cc1ccccc1.COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)N.C[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.Cl.Cl.ClC(Cl)Cl.O=C(O)Cc1ccncc1>>COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)Cc1ccncc1",
        "output": "133"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CO.COC(=O)Cc1ccc(Oc2ccc(NC(=O)c3ccc(Cl)c(Cl)c3)cc2)c(CNS(=O)(=O)c2ccc(F)cc2)c1.Cl.[Na+].[OH-]>>O=C(O)Cc1ccc(Oc2ccc(NC(=O)c3ccc(Cl)c(Cl)c3)cc2)c(CNS(=O)(=O)c2ccc(F)cc2)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cc2cc(N)ccc2[nH]1.O=C(NCCc1cccnc1)c1cc2nccc(Cl)c2s1>>Cc1cc2cc(Nc3ccnc4cc(C(=O)NCCc5cccnc5)sc34)ccc2[nH]1",
        "output": "927"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=C(O)c1ccc2ccccc2n1.O=S(Cl)Cl>>COC(=O)c1ccc2ccccc2n1",
        "output": "331"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc(N)cc1-n1ccn2nc(-c3cccnc3)cc12.O=C(O)c1cc(Cl)cc(S(F)(F)(F)(F)F)c1>>Cc1ccc(NC(=O)c2cc(Cl)cc(S(F)(F)(F)(F)F)c2)cc1-n1ccn2nc(-c3cccnc3)cc12",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CCNCC1.ClCCl>>CC(=O)N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "369"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCC2=NCCCN2CC1.CCC(=O)O.ClCCl.NS(=O)(=O)CC1OB(O)c2cc(Oc3ccccc3)ccc21.O=C(n1ccnc1)n1ccnc1>>CCC(=O)NS(=O)(=O)CC1OB(O)c2cc(Oc3ccccc3)ccc21",
        "output": "644"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1cn(-c2ccc(S(=O)(=O)Nc3cc(F)c(C(=O)OC)cc3F)cc2)nn1.CO.Cl.[Li+].[OH-]>>CCc1cn(-c2ccc(S(=O)(=O)Nc3cc(F)c(C(=O)O)cc3F)cc2)nn1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCC1CCCCO1.BrCc1ccc(-c2ccno2)cc1.Cc1noc2cc3c(cc12)C1(CO3)C(=O)Nc2ccccc21>>Cc1noc2cc3c(cc12)C1(CO3)C(=O)N(Cc2ccc(-c3ccno3)cc2)c2ccccc21",
        "output": "688"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.CCC(=O)C(CC1CCC(Cc2ccc(OC)cc2)CC1)C(=O)CC>>CCC(=O)C(CC1CCC(Cc2ccc(O)cc2)CC1)C(=O)CC",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOc1nn(-c2ccccc2)c(NC(=O)N[C@@H]2CN(CC(=O)[O-])C[C@H]2c2ccc(F)c(F)c2)c1C.CO.Cl.O.[Cl-].[Li+].[Na+].[OH-]>>CCOc1nn(-c2ccccc2)c(NC(=O)N[C@@H]2CN(CC(=O)O)C[C@H]2c2ccc(F)c(F)c2)c1C",
        "output": "151"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)C(C)c1ccc(C2CCN(C(=O)OC(C)(C)C)CC2)cc1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)C(C)c1ccc(C2CCNCC2)cc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2ccc3nc(OC4CCN(c5ncc(Cl)cn5)CC4)sc3c2)CC1.ClCCl.O=C(O)C(F)(F)F>>Clc1cnc(N2CCC(Oc3nc4ccc(C5CCNCC5)cc4s3)CC2)nc1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(C)=O.CN(Cc1c(N)cccc1Br)C(=O)OC(C)(C)C.Cl.O=C([O-])O.[Na+]>>CNCc1c(N)cccc1Br",
        "output": "887"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(OC[C@H](O)CNC(C)(C)Cc1ccc2ccccc2c1)c1ccccc1-c1ccc(C#N)cc1.CN(C)C=O.O.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>CC(OC[C@H](O)CNC(C)(C)Cc1ccc2ccccc2c1)c1ccccc1-c1ccc(-c2nnn[nH]2)cc1",
        "output": "390"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.Nc1ccc(F)cc1F.O=C(Cl)C=Cc1ccccc1.O=C([O-])O.[Na+].c1ccncc1>>O=C(C=Cc1ccccc1)Nc1ccc(F)cc1F",
        "output": "10"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCCCC1.CCN(CC)CC.COc1cccc(CC(N)c2ccccc2)c1.Cl.ClC(Cl)Cl.O=C(Cl)CCl>>COc1cccc(CC(NC(=O)CCl)c2ccccc2)c1",
        "output": "206"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.Cl.Nc1cc(Cl)c(O)c(Cl)c1.O>>CC(=O)Nc1cc(Cl)c(O)c(Cl)c1",
        "output": "6"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Cc1c[nH]c2cc([N+](=O)[O-])ccc12.Cc1c[nH]c2cccc([N+](=O)[O-])c12.[Pd]>>Cc1c[nH]c2cc(N)ccc12",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)c1cc(C(=O)N2CCCCC2)ccc1OCc1ccccc1.Cl.O.[Li+].[OH-]>>O=C(O)c1cc(C(=O)N2CCCCC2)ccc1OCc1ccccc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)O)cc1Cl.ClCCl.Nc1ccc(C(F)(F)F)cn1.O.O=C1CCC(=O)N1Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccncc1>>CS(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)Nc2ccc(C(F)(F)F)cn2)cc1Cl",
        "output": "368"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCNC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(C(=O)O)cc23)cc1F.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CON.F[P-](F)(F)(F)(F)F>>CCNC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(C(=O)NOC)cc23)cc1F",
        "output": "741"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CI.COCCc1cccc(OC(Br)OCC[Si](C)(C)C)c1.CS(C)=O.C[Si](C)(C)CCOCOc1ccc(Br)c(CCO)c1.O.OCCc1cc(O)ccc1Br.[K+].[OH-]>>COCCc1cc(OCOCC[Si](C)(C)C)ccc1Br",
        "output": "140"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.COc1ccccc1C1(O)CCC(=O)C2CNCC21.COc1ccccc1CC(=O)O.Cl.ClCCl.O.Oc1cccc2[nH]nnc12>>COc1ccccc1CC(=O)N1CC2C(=O)CCC(O)(c3ccccc3OC)C2C1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.NC1CC1.O=[N+]([O-])c1cnc(Cl)nc1Cl>>O=[N+]([O-])c1cnc(Cl)nc1NC1CC1",
        "output": "166"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.Cc1c(-c2ccc(OCc3ccccc3)cc2)[nH]c2ccc(OCc3ccccc3)cc12.ClCCCOc1ccc(CBr)cc1.O.[H-].[Na+]>>Cc1c(-c2ccc(OCc3ccccc3)cc2)n(Cc2ccc(OCCCCl)cc2)c2ccc(OCc3ccccc3)cc12",
        "output": "528"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CN(C)C=O.Cc1cc(-c2cc3ncccc3c(Cl)n2)ccc1N(C)C.NC1CC1.O.O=C(O)C(F)(F)F>>Cc1cc(-c2cc3ncccc3c(NC3CC3)n2)ccc1N(C)C",
        "output": "110"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.Cn1cc(-c2ccc(CO)c(F)c2)cn1>>Cn1cc(-c2ccc(C=O)c(F)c2)cn1",
        "output": "179"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Nc1c([N+](=O)[O-])c(Cl)nc2ccccc12.O=S(=O)([O-])[O-].[H][H].[Mg+2].[Pt]>>Nc1c(Cl)nc2ccccc2c1N",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CS(C)=O.C[C@@H]1CNCCN1.Cc1cc(F)ccc1-c1cc(Cl)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C([O-])[O-].[K+].[K+].[Na+].[OH-]>>Cc1cc(F)ccc1-c1cc(N2CCN[C@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "220"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)c1cc(C(C)(C)C)on1.Cl.[Na+].[OH-]>>CC(C)(C)c1cc(C(=O)O)no1",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCCCCCSc1ccccc1.O=C(Nc1cccc(C2CCNCC2)c1)C1CC1>>O=C(Nc1cccc(C2CCN(CCCCCCSc3ccccc3)CC2)c1)C1CC1",
        "output": "138"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1c([N+](=O)[O-])cc(NC(=O)OC(C)(C)C)cc1[N+](=O)[O-].O=C(O)C(F)(F)F>>Cc1c([N+](=O)[O-])cc(N)cc1[N+](=O)[O-]",
        "output": "782"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.COc1c(C)cc(C)c2c1C(=O)C(C)(Cc1ccccc1)C2.[Al+3].[Cl-].[Cl-].[Cl-].[I-].[Na+]>>Cc1cc(C)c2c(c1O)C(=O)C(C)(Cc1ccccc1)C2",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCc1nc2c(Cl)nc3ccccc3c2n1Cc1cc(-c2cccnc2)no1.CO.N>>CCOCc1nc2c(N)nc3ccccc3c2n1Cc1cc(-c2cccnc2)no1",
        "output": "682"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)CCC(C(=O)O)CC1.O=S(Cl)Cl>>CC1(C)CCC(C(=O)Cl)CC1",
        "output": "53"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CNC1CN(C(=O)C2CCN(C(=O)C3(C)CC3)CC2)CC1c1ccc(Cl)c(Cl)c1.O=C(O)CC1CCCC1>>CN(C(=O)CC1CCCC1)C1CN(C(=O)C2CCN(C(=O)C3(C)CC3)CC2)CC1c1ccc(Cl)c(Cl)c1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)OC(=O)Cl.CCN(CC)CC.CN(C)C(=O)c1ccc(Nc2ncnc3c2c(F)cn3C2CCNCC2)c(F)c1.Cl.ClCCl.O>>CC(C)OC(=O)N1CCC(n2cc(F)c3c(Nc4ccc(C(=O)N(C)C)cc4F)ncnc32)CC1",
        "output": "219"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(CO)(C(=O)O)n1cc(-c2cc(F)cc3c2-c2ccccc2[C@]3(O)C(F)(F)F)cn1.CCO.O.O=C([O-])O.[Na+]>>CC(CO)(CO)n1cc(-c2cc(F)cc3c2-c2ccccc2[C@]3(O)C(F)(F)F)cn1",
        "output": "231"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCO[C@H](CO)C1.CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OC[C@@H]2CN(C(=O)OC(C)(C)C)CCO2)cc1",
        "output": "197"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCOc1ccc(C(=O)Oc2ccc(CN(CC(=O)OC(C)(C)C)C(=O)c3ccc(NC(=O)Cc4ccc(C)c(OC)c4)cc3)cc2)cc1.ClCCl.O=C(O)C(F)(F)F>>CCCCCCCOc1ccc(C(=O)Oc2ccc(CN(CC(=O)O)C(=O)c3ccc(NC(=O)Cc4ccc(C)c(OC)c4)cc3)cc2)cc1",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C(=O)Cl)c1ccccc1.Cc1cc(C)nc(Sc2ccc(O)cc2)n1>>Cc1cc(C)nc(Sc2ccc(OC(=O)N(C)c3ccccc3)cc2)n1",
        "output": "425"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1cccn(Cc2cccc(-c3ccccc3)c2)c1=O.[Na+].[OH-]>>O=C(O)c1cccn(Cc2cccc(-c3ccccc3)c2)c1=O",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1nc(OC[C@H]2C[C@H]2C#N)nc(N2CCC(c3ccc(N)c(C(N)=O)n3)CC2)n1.Cl.[Li+].[OH-]>>N#C[C@@H]1C[C@@H]1COc1nc(C(=O)O)nc(N2CCC(c3ccc(N)c(C(N)=O)n3)CC2)n1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1=C(C(=O)O)C(c2ccc(Cl)cc2)CC(=O)N1.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Cl.ClCCCl.Nc1cc2cn[nH]c2cc1F>>CC1=C(C(=O)Nc2cc3cn[nH]c3cc2F)C(c2ccc(Cl)cc2)CC(=O)N1",
        "output": "170"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(O)c1coc(CCl)n1.CI.N#N>>COC(C)(C)c1coc(CCl)n1",
        "output": "140"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COc1cc[nH]c1/C=C1\\C(=O)Nc2ccc(N)c(C#CCO)c21.O=C(Cl)Cc1cccs1>>COc1cc[nH]c1/C=C1\\C(=O)Nc2ccc(NC(=O)Cc3cccs3)c(C#CCO)c21",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCS(=O)(=O)c1ccc(F)c(F)c1.CO.[K+].[OH-]>>CCS(=O)(=O)c1ccc(OC)c(F)c1",
        "output": "485"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)CCc1cc(Cl)c(CN2CCC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl.C[Si](C)(C)Br.ClCCl>>O=C(O)CCc1cc(Cl)c(CN2CCC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl",
        "output": "278"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC.CO.COC(=O)CCCCCC[C@@H]1C(=O)CC[C@H]1C=CC(O)CC1CCCCC1.Cl.[Na+].[OH-]>>O=C(O)CCCCCC[C@@H]1C(=O)CC[C@H]1C=CC(O)CC1CCCCC1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.Cc1cc([N+](=O)[O-])ccc1SCc1ccccn1>>Cc1cc(N)ccc1SCc1ccccn1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CSc1nc(NCC(c2ccccc2)c2ccccc2)c2ncn(C3CCCCO3)c2n1.O.O=C([O-])O.O=S(=O)([O-])O[O-].O=S([O-])OO.[K+].[K+].[K+].[Na+]>>CS(=O)(=O)c1nc(NCC(c2ccccc2)c2ccccc2)c2ncn(C3CCCCO3)c2n1",
        "output": "840"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CCOc1cc2c(cc1OCC)-c1cc(=O)c(C(=O)O)cn1C(CO)C2.CN(C)c1ccncc1.ClCCl.c1ccncc1>>CCOc1cc2c(cc1OCC)-c1cc(=O)c(C(=O)O)cn1C(COC(C)=O)C2",
        "output": "126"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Br.CC(=O)O.CCOC(=O)c1c(OCc2ccccc2)c(OCc2ccccc2)c(C(=O)N(C)C)n1-c1ccc(OC)cc1.ClCCl>>CCOC(=O)c1c(O)c(OCc2ccccc2)c(C(=O)N(C)C)n1-c1ccc(OC)cc1",
        "output": "264"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.[N-]=[N+]=NCCCO>>Cc1ccc(S(=O)(=O)OCCCN=[N+]=[N-])cc1",
        "output": "197"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.ClCCl.O=[N+]([O-])c1cnc(NCc2ccccc2OC(F)(F)F)nc1NC[C@@H]1CC[C@H](O)CC1>>CS(=O)(=O)O[C@H]1CC[C@@H](CNc2nc(NCc3ccccc3OC(F)(F)F)ncc2[N+](=O)[O-])CC1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1cccc(Br)n1.C1CNC1.CS(C)=O.Cl.O=C([O-])[O-].[K+].[K+]>>Brc1cccc(N2CCC2)n1",
        "output": "647"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCN(CCCN)CCN(C(=O)OC(C)(C)C)CCN(C(=O)OC(C)(C)C)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21>>CC(C)(C)OC(=O)N1CCN(CCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@@H]32)CCN(C(=O)OC(C)(C)C)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1ccccc1S(=O)(=O)Nc1cc(C(F)(F)F)ccc1Nc1ccc(C#N)cc1.Cl.[Na+].[OH-]>>N#Cc1ccc(Nc2ccc(C(F)(F)F)cc2NS(=O)(=O)c2ccccc2C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1ccc(OCc2c(C3CCCCC3)noc2C)nc1.NC1CC1>>Cc1onc(C2CCCCC2)c1COc1ccc(C(=O)NC2CC2)cn1",
        "output": "862"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.Cl.ClCCl.NCCc1c[nH]c2ccc(Cl)cc12.O=C(Cl)c1ccc(CCl)cc1>>O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(CCl)cc1",
        "output": "271"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cccc(OC)c1CO.O=S(Cl)Cl.c1ccccc1>>COc1cccc(OC)c1CCl",
        "output": "81"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.Cc1cccc(N=C=O)c1.Nc1ccc(C#Cc2ccc3nccn3n2)cc1.O>>Cc1cccc(NC(=O)Nc2ccc(C#Cc3ccc4nccn4n3)cc2)c1",
        "output": "473"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COCCOCOc1ccc(CCOC(C)=O)cc1OC.[BH4-].[Cl-].[Li+].[NH4+]>>COCCOCOc1ccc(CCO)cc1OC",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)N(C)C.CC(C)(C)[O-].Cc1cnc(Nc2ncnc3ccc(O)cc23)cn1.Fc1ncc(OCCCOC2CCCCO2)cc1Cl.O.[K+]>>Cc1cnc(Nc2ncnc3ccc(Oc4ncc(OCCCOC5CCCCO5)cc4Cl)cc23)cn1",
        "output": "727"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCO.COCCCCCCCS(=O)(=O)c1ccc(C(=O)OC)cc1.[Na+].[OH-]>>COCCCCCCCS(=O)(=O)c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)/N=N/C(=O)OCC.COC(=O)CCc1ccc(O)cc1.COc1ccc(COC(c2ccc(O[C@H](CO)Cc3ccccc3)c(C)c2)(C(F)(F)F)C(F)(F)F)cc1.[Cl-].[NH4+].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)CCc1ccc(OC[C@H](Cc2ccccc2)Oc2ccc(C(OCc3ccc(OC)cc3)(C(F)(F)F)C(F)(F)F)cc2C)cc1",
        "output": "550"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(CO)cc1I.ClCCl.O=[Mn]=O>>Cc1ccc(C=O)cc1I",
        "output": "179"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.COc1cc(OC)c(F)c(COc2cnc(Nc3cc(CO)n(C)n3)nc2)c1F.CS(=O)(=O)Cl.ClCCl.O>>COc1cc(OC)c(F)c(COc2cnc(Nc3cc(COS(C)(=O)=O)n(C)n3)nc2)c1F",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1ccc([N+](=O)[O-])cc1O.[Pd]>>COC(=O)c1ccc(N)cc1O",
        "output": "772"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C1=Cc2cc(C(C)=O)ccc2OC1C(F)(F)F.CC[SiH](CC)CC.ClCCl.O>>CCOC(=O)C1=Cc2cc(CC)ccc2OC1C(F)(F)F",
        "output": "92"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccccc4)oc4c5c(ccc4c3=O)NC(=O)CO5)cc2)CCC1.NC1(c2ccc(-c3c(-c4ccccc4)oc4c(ccc5[nH]ncc54)c3=O)cc2)CCC1>>NC1(c2ccc(-c3c(-c4ccccc4)oc4c5c(ccc4c3=O)NC(=O)CO5)cc2)CCC1",
        "output": "793"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC[SiH](CC)CC.COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.Cc1ccc2ccc(F)cc2c1C=O.O=C(O)C(F)(F)F>>COc1cc(O)c2c(c1C(=O)NCc1c(C)ccc3ccc(F)cc13)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C",
        "output": "996"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCCCO.CCN(CC)CC.CCOC(C)=O.C[C@@H]1CCc2ncnc(Cl)c21>>C[C@@H]1CCc2ncnc(N3CCN(C(=O)OC(C)(C)C)CC3)c21",
        "output": "296"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.Cc1cc(CCCCCOc2c(Cl)cc(C#N)cc2Cl)on1.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>Cc1cc(CCCCCOc2c(Cl)cc(-c3nnn[nH]3)cc2Cl)on1",
        "output": "390"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)CN(S(C)(=O)=O)CCN1.O=Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1>>CC1(C)CN(S(C)(=O)=O)CCN1Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1",
        "output": "792"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.O=Cc1cccc(C=O)c1>>O=Cc1cccc(CO)c1",
        "output": "356"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN1CCN(c2cccc(N)c2)CC1.Cc1cccc(C)c1-c1ccc(C(=O)O)c2nccnc12.Cc1cccc(C)c1B(O)O.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCN1CCN(c2cccc(NC(=O)c3ccc(-c4c(C)cccc4C)c4nccnc34)c2)CC1",
        "output": "739"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1=Cc2ccccc2C(=C2CCNCC2)c2ccccc21.CC(=O)CCCBr>>CC(=O)CCCN1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cc(F)c(Sc2ccc(C)cc2)nc1Cl.O.[Li+].[OH-]>>Cc1ccc(Sc2nc(Cl)c(C(=O)O)cc2F)cc1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(O)c1ccccc1Br.O=S(=O)(O)O.O=[N+]([O-])O>>O=C(O)c1cc([N+](=O)[O-])ccc1Br",
        "output": "21"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CCOCC.ClCCl.O=C(O)COc1ccccc1Br.On1nnc2ccccc21.c1ccc(C[C@@H]2CN(Cc3ccccc3)CCN2)cc1>>O=C(COc1ccccc1Br)N1CCN(Cc2ccccc2)C[C@H]1Cc1ccccc1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C)(NC(=O)c1cc(Cl)c2ccccc2c1OCC1CCNCC1)C(=O)O.Cl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCC(C)(NC(=O)c1cc(Cl)c2ccccc2c1OCC1CCN(C(=O)C(F)(F)F)CC1)C(=O)O",
        "output": "397"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C(Cl)C(=O)Cl.O=C(O)Cc1ccc(F)c(F)c1>>O=C(Cl)Cc1ccc(F)c(F)c1",
        "output": "56"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)C1(Sc2ccnc3ccc(O)cc23)CCC1.CO.O.[Na+].[OH-]>>O=C(O)C1(Sc2ccnc3ccc(O)cc23)CCC1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)C#N.CC(C)(C)OC(=O)N[C@H](Cc1ccc(C(C)(C)C)cc1)C(=O)O.CCN1CCOCC1.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F.N#N.Nc1ccccc1N.O>>CC(C)(C)OC(=O)N[C@H](Cc1ccc(C(C)(C)C)cc1)c1nc2ccccc2[nH]1",
        "output": "512"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C[C@@H]1C(=O)N(Cc2ccccc2)C[C@@H]1NC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>C[C@@H]1C(=O)N(Cc2ccccc2)C[C@@H]1N",
        "output": "538"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.Cc1nc2ccc(N)cc2o1.O=C(Cl)OCC(Cl)(Cl)Cl.c1ccncc1>>Cc1nc2ccc(NC(=O)OCC(Cl)(Cl)Cl)cc2o1",
        "output": "102"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)NC(C)C.CO.Cc1nc2n(c(=O)c1CCCl)CCCC2O.Cl.Fc1ccc2c(C3CCNCC3)noc2c1>>Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.O=C(Oc1cccc(O)c1[N+](=O)[O-])c1ccccc1.OCc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(Oc1cccc(OCc2ccccc2)c1[N+](=O)[O-])c1ccccc1",
        "output": "347"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cc(O)cc(=O)n1Cc1cccc(F)c1.ClCCl.O=C1CCC(=O)N1Br>>Cc1cc(O)c(Br)c(=O)n1Cc1cccc(F)c1",
        "output": "518"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(Nc1ccc(-c2ccccc2)nc1)C1(c2ccc3c(c2)OCO3)CC1.O=C(Nc1ccc(Br)nc1)C1(c2ccc3c(c2)OCO3)CC1.OB(O)c1ccccc1Cl>>O=C(Nc1ccc(-c2ccccc2Cl)nc1)C1(c2ccc3c(c2)OCO3)CC1",
        "output": "869"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)CC1C(NC(=O)OC(C)(C)C)CCCN1C(=O)OCc1ccccc1.Cl.[Na+].[OH-]>>CC(C)(C)OC(=O)NC1CCCN(C(=O)OCc2ccccc2)C1CC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cncc(C(=O)NC23CCCC(C(=O)O)(CC2)C3)n1.F[P-](F)(F)(F)(F)F.Nc1ccccn1.O>>Cc1cncc(C(=O)NC23CCCC(C(=O)Nc4ccccn4)(CC2)C3)n1",
        "output": "368"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1NCCc2cc(F)c(F)cc21.O=C(O)c1cc2ncc(Cl)cn2n1>>CC1c2cc(F)c(F)cc2CCN1C(=O)c1cc2ncc(Cl)cn2n1",
        "output": "952"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CN(C)c1ccncc1.COc1cc2ncnc(Oc3cccc(N)c3)c2cc1OC.O=C(Nc1cc(C(F)(F)F)nn1-c1ccc(F)cc1)Oc1ccccc1>>COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(F)(F)F)nn4-c4ccc(F)cc4)c3)c2cc1OC",
        "output": "948"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(C)=O.CN(C)CC(=O)O.Cc1cc(F)ccc1O.Cc1cccc([N+](=O)[O-])c1Br.Cl.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1cc(F)ccc1Oc1c(C)cccc1[N+](=O)[O-]",
        "output": "238"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.Cc1cccc(C)c1N.Cl.c1ccncc1>>Cc1ccc(S(=O)(=O)Nc2c(C)cccc2C)cc1",
        "output": "68"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCC(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C1N[C@@H]2CCCC[C@H]2N1C1CCN(C2CCNCC2)CC1>>CCCC(=O)N1CCC(N2CCC(N3C(=O)N[C@@H]4CCCC[C@H]43)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.C[C@H]1CN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CCN1.Cc1ccncc1C(=O)O.ClCCl.F[P-](F)(F)(F)(F)F.O.On1nnc2ccccc21>>Cc1ccncc1C(=O)N1CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)C[C@@H]1C",
        "output": "256"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=C(C)CBr.CC(C)=O.ClCCl.O=C([O-])[O-].Oc1ccc(Br)cc1.[K+].[K+]>>C=C(C)COc1ccc(Br)cc1",
        "output": "77"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(=O)Cl.CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(C2(c3cccc(O)c3)CCCN(CC3CC3)C2)cc1.ClCCl>>CCC(=O)Oc1cccc(C2(c3ccc(C)cc3)CCCN(CC3CC3)C2)c1",
        "output": "111"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)Cn1cnc2c(N)nc3ccccc3c21.O=S(=O)(O)O.O=[N+]([O-])O.[NH4+].[OH-]>>CC(C)Cn1cnc2c(N)nc3ccc([N+](=O)[O-])cc3c21",
        "output": "21"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cc1c(CC(N)=O)c2cc(O)ccc2n1Cc1ccccc1.Cl.Ic1ccccc1.[H-].[Na+].c1ccncc1>>Cc1c(CC(N)=O)c2cc(Oc3ccccc3)ccc2n1Cc1ccccc1",
        "output": "382"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N(C)C.CC(C)(C)[O-].CCOC(C)=O.NCc1ccccc1-n1cccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=c1[nH]nc(Cl)c2cc(Br)ccc12.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>O=c1[nH]nc(Cl)c2cc(NCc3ccccc3-n3cccc3)ccc12",
        "output": "932"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O.O=C1Cc2cc(F)ccc2Sc2ccccc21.[BH4-].[Na+]>>OC1Cc2cc(F)ccc2Sc2ccccc21",
        "output": "24"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc(OCc2ccccc2)c(C2CCCC2)c1.C1CCOC1.CN(C)C=O.Cl.[Li]CCCC>>O=Cc1ccc(OCc2ccccc2)c(C2CCCC2)c1",
        "output": "638"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)c1ccc(N)c(=O)n1CC(=O)OC(C)(C)C.CN1CCOCC1.Cc1cccc(S(=O)(=O)Cl)c1.ClCCl>>Cc1cccc(S(=O)(=O)Nc2ccc(C(C)C)n(CC(=O)OC(C)(C)C)c2=O)c1",
        "output": "554"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.Cn1nc(C(C)(C)C)cc1N.O=C(Cl)Oc1ccccc1.O=C([O-])[O-].[K+].[K+]>>Cn1nc(C(C)(C)C)cc1NC(=O)Oc1ccccc1",
        "output": "700"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(CN(C(=O)C2CCCc3c(OCc4ccccc4)cccc32)c2ccc(C(C)C)nc2)c(OC)n1.CSc1ccccc1.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>COc1ccc(CN(C(=O)C2CCCc3c(O)cccc32)c2ccc(C(C)C)nc2)c(OC)n1",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.Cc1cc(Oc2ccc(C=O)cc2)ccc1Cl.[Br-].[H-].[Na+]>>C=Cc1ccc(Oc2ccc(Cl)c(C)c2)cc1",
        "output": "649"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCCc1nc2c(N3CCN(Cc4cccnc4)CC3)c(Br)cnc2[nH]1.ClCCl.NCc1ccc(-c2nc3c(N4CCN(Cc5cccnc5)CC4)c(Br)cnc3[nH]2)cc1.O=C(O)C(F)(F)F>>NCCc1nc2c(N3CCN(Cc4cccnc4)CC3)c(Br)cnc2[nH]1",
        "output": "538"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CNCCN1.CCOC(=O)c1cn(C)c2nc3c(F)c(F)c(F)cc3cc2c1=O.CS(C)=O.O>>CCOC(=O)c1cn(C)c2nc3c(F)c(N4CCNCC4)c(F)cc3cc2c1=O",
        "output": "676"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COc1cc2ncnc(Oc3ccc(N)c(Cl)c3)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.OC1CCCCC1.[Na+]>>COc1cc2ncnc(Oc3ccc(NC(=O)OC4CCCCC4)c(Cl)c3)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(C(=O)N2[C@@H](c3csc(N(C)C)n3)[C@@H](c3cnccn3)C[C@@]2(CC(C)C)C(=O)OC(C)(C)C)ccc1C(C)(C)C.O=C(O)C(F)(F)F>>COc1cc(C(=O)N2[C@@H](c3csc(N(C)C)n3)[C@@H](c3cnccn3)C[C@@]2(CC(C)C)C(=O)O)ccc1C(C)(C)C",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCC.CCOC(C)=O.C[C@@H](/C=C\\[C@H](C[C@H](O[Si](C)(C)C(C)(C)C)[C@H](C)/C=C/COC(c1ccccc1)(c1ccccc1)c1ccccc1)O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](C)CCCO[Si](C)(C)C(C)(C)C.F.c1ccncc1.c1ccncc1>>C[C@@H](/C=C\\[C@H](C[C@H](O[Si](C)(C)C(C)(C)C)[C@H](C)/C=C/COC(c1ccccc1)(c1ccccc1)c1ccccc1)O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](C)CCCO",
        "output": "708"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.O.O=C(CBr)c1ccccc1.O=C1OC(c2ccccc2)(c2ccccc2)C2CNCCN12>>O=C(CN1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1)c1ccccc1",
        "output": "413"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc(-c2csc(COc3ccc(F)c(C(N)=O)c3F)n2)cc1.ClCCl.O=C([O-])O.[Na+]>>NC(=O)c1c(F)ccc(OCc2nc(-c3ccc(O)cc3)cs2)c1F",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCCCCCCCCCc1c(C)[nH]c(C)cc1=O.O=C([O-])[O-].O=S(=O)(O)O.O=[N+]([O-])O.[Na+].[Na+]>>CCCCCCCCCCCCCCCCc1c(C)[nH]c(C)c([N+](=O)[O-])c1=O",
        "output": "328"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COC(=O)C(Cc1ccc(F)cc1)c1ccc(S(C)(=O)=O)cc1.[K+].[OH-]>>CS(=O)(=O)c1ccc(C(Cc2ccc(F)cc2)C(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cc(COc2ccc(C(=O)NCC3(C4CCNCC4)C(=O)NC(=O)NC3=O)cc2)c2ccccc2n1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C1CCOCC1>>Cc1cc(COc2ccc(C(=O)NCC3(C4CCN(C5CCOCC5)CC4)C(=O)NC(=O)NC3=O)cc2)c2ccccc2n1",
        "output": "187"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.CN(C)C=O.C[C@H](NC(=O)OC(C)(C)C)C(=O)O.O=C1CCC(=O)N1O.[NH4+].[OH-]>>C[C@H](NC(=O)OC(C)(C)C)C(N)=O",
        "output": "313"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCN1.CC#N.O=C(CCl)Nc1cn2nc(Oc3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)ccc2n1>>O=C(CN1CCOCC1)Nc1cn2nc(Oc3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)ccc2n1",
        "output": "340"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C=C(C(=O)OC)c1ccccc1OC.[K+].[OH-]>>C=C(C(=O)O)c1ccccc1OC",
        "output": "58"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(c2ccc(C=O)cc2)CC1.Fc1ccc(CCNCc2ccc(C3CC3)cc2)cc1C(F)(F)F.NCCc1cccc(C(F)(F)F)c1.[BH4-].[Na+]>>CC1(c2ccc(CNCCc3cccc(C(F)(F)F)c3)cc2)CC1",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.OCc1cccc(Nc2ncc(-c3ccc(OC(F)F)cc3)cn2)c1>>CS(=O)(=O)OCc1cccc(Nc2ncc(-c3ccc(OC(F)F)cc3)cn2)c1",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CS(C)=O.Cc1c(Br)cccc1NC(=O)C(F)c1ccccn1.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1c(NC(=O)C(F)c2ccccn2)cccc1B1OC(C)(C)C(C)(C)O1",
        "output": "942"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)S(=O)(=O)c1ccccc1[N+](=O)[O-].CNS(=O)(=O)c1ccccc1N>>CN(C)S(=O)(=O)c1ccccc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.CCOC(=O)C(Cc1cnc(NC(=O)OC(C)(C)C)s1)C(=O)OCC.[K+].[OH-]>>CCOC(=O)C(Cc1cnc(NC(=O)OC(C)(C)C)s1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CI.CN(C)C=O.CN1C(=O)C[C@H](c2ccccc2)[C@@H]1[C@H](O)c1cccs1.O.[H-].[Na+]>>CO[C@H](c1cccs1)[C@H]1[C@@H](c2ccccc2)CC(=O)N1C",
        "output": "140"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CNC(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1.CO.II.[BH4-].[Na+]>>CNCc1ccccc1-c1ccc(C(F)(F)F)cc1",
        "output": "215"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(C)cc(C)c1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COc1cc(C)cc(CBr)c1",
        "output": "29"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cc1ccc(N)nc1.O=C(CBr)c1ccccc1Cl.[Na+].[OH-]>>Cc1ccc2nc(-c3ccccc3Cl)cn2c1",
        "output": "508"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)CCNC(=O)c1ccc(C(Oc2cc(C)c(-c3ccc(OC(F)(F)F)cc3)c(C)c2)C(C)C)s1.Cl.[Li+].[OH-]>>Cc1cc(OC(c2ccc(C(=O)NCCC(=O)O)s2)C(C)C)cc(C)c1-c1ccc(OC(F)(F)F)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.ClCCl.O=C(O)CC[C@@H]1CC1(c1ccccc1)c1ccccc1.O=[N+]([O-])c1ccc(O)cc1>>O=C(CC[C@@H]1CC1(c1ccccc1)c1ccccc1)Oc1ccc([N+](=O)[O-])cc1",
        "output": "108"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)c1cc(C2CC2)ccc1Nc1cnc(-c2ccccc2)c(C)c1.CO.N.O.[Na+].[OH-]>>Cc1cc(Nc2ccc(C3CC3)cc2C(=O)O)cnc1-c1ccccc1",
        "output": "5"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)C1CCC(=O)CC1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.O.OCCO>>CCOC(=O)C1CCC2(CC1)OCCO2",
        "output": "265"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.CC(C)=O.CC(C)O.O=C1NC(=O)C(=C(CO)c2cccc3ccccc23)S1.O=S(=O)(O)O.O=[Cr](=O)=O>>O=CC(=C1SC(=O)NC1=O)c1cccc2ccccc12",
        "output": "183"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(CC(=O)Cl)N=[N+]=[N-].CCCCCCNC.CCN(C(C)C)C(C)C.ClCCCl>>CCCCCCN(C)C(=O)CC(C)(C)N=[N+]=[N-]",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(OC(F)F)c(Cl)c1>>O=C(Cl)c1ccc(OC(F)F)c(Cl)c1",
        "output": "448"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)c1cc2ccc(SCCCc3cc4c(cc3O)CC(CCc3ccccc3)O4)cc2nc1OC.[Na+].[OH-]>>COc1nc2cc(SCCCc3cc4c(cc3O)CC(CCc3ccccc3)O4)ccc2cc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCOC(=O)CBr.Cc1[nH]c2c(c1Cc1ccccc1[N+](=O)[O-])C(=O)CC(C)(C)C2.ClCCl.O=C([O-])[O-].[Cl-].[I-].[K+].[K+].[K+].[NH4+]>>CCOC(=O)Cn1c(C)c(Cc2ccccc2[N+](=O)[O-])c2c1CC(C)(C)CC2=O",
        "output": "310"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.ClCCl.Nc1ccc(Br)cc1.O=C(Cl)Cc1ccccc1>>O=C(Cc1ccccc1)Nc1ccc(Br)cc1",
        "output": "9"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCC[Si](C)(C)c1cccc(O)c1.CN(C)C=O.COS(=O)(=O)OC.O.[H-].[Na+]>>CCCCCC[Si](C)(C)c1cccc(OC)c1",
        "output": "317"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(Cl)c(Cl)cc1[N+](=O)[O-].Cl.[Li+].[OH-]>>O=C(O)c1cc(Cl)c(Cl)cc1[N+](=O)[O-]",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCN(C2CCNCC2)C1.COCc1c(C(=O)O)c(C)nn1-c1cccc(C(F)(F)F)c1>>COCc1c(C(=O)N2CCC(N3CCCC3)CC2)c(C)nn1-c1cccc(C(F)(F)F)c1",
        "output": "733"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCCc1nnc(OC2CCNCC2)c(C(F)(F)F)c1-c1ccc(OC2CCCCC2)cc1.Cl.Cl.ClCCl>>CCCCc1nnc(OC2CCN(C)CC2)c(C(F)(F)F)c1-c1ccc(OC2CCCCC2)cc1",
        "output": "217"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O.O=S([O-])S(=O)[O-].O=[N+]([O-])c1ccc(F)c(Cl)c1NCCO.[Na+].[Na+]>>Nc1ccc(F)c(Cl)c1NCCO",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ncc(C)c(OC)c1C.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1c(C)cnc(CO)c1C",
        "output": "546"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.O=C1CCC(=O)N1I.O=[N+]([O-])c1ccc(CN2CCOCC2)cc1>>Nc1ccc(CN2CCOCC2)cc1",
        "output": "507"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1CCN(CCCN)CC1.NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)Oc1ccccc1>>CN1CCN(CCCNC(=O)Nc2snc(OCc3c(F)cc(Br)cc3F)c2C(N)=O)CC1",
        "output": "488"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COCC(=O)Cl.Cc1[nH]c2c(-c3ccc(F)cc3OCC3CC3)ncnc2c1C(=O)N[C@@H]1CNC[C@H]1O.Cl>>COCC(=O)N1C[C@@H](O)[C@H](NC(=O)c2c(C)[nH]c3c(-c4ccc(F)cc4OCC4CC4)ncnc23)C1",
        "output": "125"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.COc1ccc(F)cc1C(=O)c1ccc(Cl)nc1N>>COc1ccc(F)cc1C(=O)c1ccc(NC2CCN(C(=O)OC(C)(C)C)CC2)nc1N",
        "output": "70"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cc1nc2ccc(C(=O)N3CCNCC3)cn2c1-c1ccccc1.O=C(Cl)C1CCCCC1>>Cc1nc2ccc(C(=O)N3CCN(C(=O)C4CCCCC4)CC3)cn2c1-c1ccccc1",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(OC)N(C)C.COc1ccc(C(C)=O)cc1>>COc1ccc(C(=O)/C=C/N(C)C)cc1",
        "output": "898"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OCc1ncc(-c2ccc3c(c2)N(C)C(=O)C3(C)C)o1.CO.O=C([O-])[O-].[K+].[K+]>>CN1C(=O)C(C)(C)c2ccc(-c3cnc(CO)o3)cc21",
        "output": "348"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCOc1cccc(Oc2ccc(C#N)cc2)c1.CCO.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CCCCOc1cccc(Oc2ccc(CN)cc2)c1",
        "output": "175"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(=O)Cn1nc(C(C)(C)C)cc1NC(=O)Oc1ccccc1.COc1cc2ncnc(Oc3cccc(N)c3)c2cc1OC>>CCOC(=O)Cn1nc(C(C)(C)C)cc1NC(=O)Nc1cccc(Oc2ncnc3cc(OC)c(OC)cc23)c1",
        "output": "948"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.CCCCCC.CCO.CCOC(=O)c1oc2cc(OC)c(Cl)cc2c1C.CCOC(C)=O.Cl.ClCCl>>CCOC(=O)c1oc2cc(O)c(Cl)cc2c1C",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CCNCC1.O=C(O)c1cn(CCF)c2cc(Cl)c(F)cc2c1=O.c1ccncc1>>CN1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3CCF)CC1",
        "output": "280"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.O=[N+]([O-])c1cc(C(F)(F)F)ccc1O.O=[Pt]>>Nc1cc(C(F)(F)F)ccc1O",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)O.CCOC(C)=O.Oc1c(F)c(F)c(F)c(F)c1F>>CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)Oc1c(F)c(F)c(F)c(F)c1F",
        "output": "108"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cc1nn(CC[C@](C)(C(=O)O)S(C)(=O)=O)cc1-c1ccccc1.ClCCl.NOC1CCCCO1.On1nnc2ccccc21>>Cc1nn(CC[C@](C)(C(=O)NOC2CCCCO2)S(C)(=O)=O)cc1-c1ccccc1",
        "output": "480"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@H](CC(=O)O)CC1.CI.CN(C)C=O.O.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)C[C@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1",
        "output": "415"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCN(CCO)CC1.CCN(CC)CC.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCN(CCOS(C)(=O)=O)CC1",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1C(=O)Cc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4(NC(=O)OC(C)(C)C)CCOCC4)cc3)cc21.N.O=CO>>CN1C(=O)Cc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)C4(N)CCOCC4)cc3)cc21",
        "output": "431"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)O)cc2cn[nH]c12.OC1CN2CCC1CC2>>Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)OC2CN3CCC2CC3)cc2cn[nH]c12",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CN(C)C1(c2ccccc2)CCC(CCCN)CC1.O=C(NCCc1c[nH]c2ccccc12)Oc1ccccc1>>CN(C)C1(c2ccccc2)CCC(CCCNC(=O)NCCc2c[nH]c3ccccc23)CC1",
        "output": "488"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C1CCNC1.CN(C)C=O.Cc1cc(F)ccc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>Cc1cc(N2CCC(N(C)C)C2)ccc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)[O-].CC(C)Oc1cccc(OC(C)C)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.CNC(=O)c1ccc(-c2cn(COCC[Si](C)(C)C)c3nc(Cl)nc(OC4CCC4)c23)cc1.Cc1nn(C)cc1N.[Na+]>>CNC(=O)c1ccc(-c2cn(COCC[Si](C)(C)C)c3nc(Nc4cn(C)nc4C)nc(OC4CCC4)c23)cc1",
        "output": "992"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrP(Br)Br.CCN1CCN(c2ccc(CO)c(Cl)c2)CC1.ClCCl>>CCN1CCN(c2ccc(CBr)c(Cl)c2)CC1",
        "output": "300"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cl.Cc1ccsc1C(N)Cc1ccccc1.ClCCl.O.O=C([O-])[O-].[Na+].[Na+]>>CCOC(=O)NC(Cc1ccccc1)c1sccc1C",
        "output": "94"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(=O)O.CO.C[Si](C)(C)C=[N+]=[N-].O=C(O)c1cccc(Oc2cccc(C(F)(F)F)c2)c1>>COC(=O)c1cccc(Oc2cccc(C(F)(F)F)c2)c1",
        "output": "195"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#CCOc1ncnc(Cl)c1F.CC#N.CC1(C)CNCC(C)(C)C1.Cl.O=C([O-])[O-].[Cl-].[K+].[K+].[NH4+]>>CC#CCOc1ncnc(N2CC(C)(C)CC(C)(C)C2)c1F",
        "output": "296"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C=CC[C@H](C)O.CCOCC.N#Cc1ccc(Br)c(F)c1.[H-].[Na+]>>C=CC[C@H](C)Oc1cc(C#N)ccc1Br",
        "output": "485"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1ccccc1Oc1ncccc1N.CN(C)C=O.O.O=C1CCC(=O)N1Br>>CC(C)(C)c1ccccc1Oc1nc(Br)ccc1N",
        "output": "779"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCc1nc2ccc(=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)OC)cc1.CCO.[Na+].[OH-]>>CCCCc1nc2ccc(=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CC(=O)Nc1cccc(-c2nc(Cl)ncc2Cl)c1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CN1CCN(c2ccc(N)cc2)CC1.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[K+].[K+].[Pd].[Pd]>>C=CC(=O)Nc1cccc(-c2nc(Nc3ccc(N4CCN(C)CC4)cc3)ncc2Cl)c1",
        "output": "808"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.O=C(NC(COCC1CCNCC1)c1ccccc1Cl)c1cc2ccc(Cl)cc2s1>>CC(C)N1CCC(COCC(NC(=O)c2cc3ccc(Cl)cc3s2)c2ccccc2Cl)CC1",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCOc1nc(N)c2nc(O)n(Cc3cccc(CC(=O)O)c3)c2n1.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)CCCCO.Cl.On1nnc2ccccc21>>CCCCOc1nc(N)c2nc(O)n(Cc3cccc(CC(=O)OCCCCN(C)C)c3)c2n1",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(-c2ncccc2Cl)cc1.CO.Cl>>Nc1ccccc1NC(=O)c1ccc(-c2ncccc2Cl)cc1",
        "output": "782"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.ClI.N#Cc1ccccc1N>>N#Cc1cc(I)ccc1N",
        "output": "466"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCl.O=C([O-])O.OC1CCCCC1c1cc(F)c(F)c(F)c1.[Na+]>>O=C1CCCCC1c1cc(F)c(F)c(F)c1",
        "output": "87"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)C1=Cc2cc(Br)ccc2N(CC(C)=O)CC1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.OCCO>>COC(=O)C1=Cc2cc(Br)ccc2N(CC2(C)OCCO2)CC1",
        "output": "265"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCN(C(C)C)C(C)C.Cc1cn2c(ccc3cc(I)ccc32)n1.N#CC1(c2cccc(S)c2)CCOCC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]>>Cc1cn2c(ccc3cc(Sc4cccc(C5(C#N)CCOCC5)c4)ccc32)n1",
        "output": "565"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.CSCc1cccc2c(C(CCC#N)c3c(F)cc(Cl)cc3F)c[nH]c12.ClCCl.O=C(OO)c1cccc(Cl)c1>>CS(=O)Cc1cccc2c(C(CCC#N)c3c(F)cc(Cl)cc3F)c[nH]c12",
        "output": "13"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.COC(=O)CBr.O=C([O-])[O-].Oc1cccc2[nH]ccc12.[K+].[K+]>>COC(=O)COc1cccc2[nH]ccc12",
        "output": "557"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1c2ccc(O)cc2C2CNCC12.CCNC(=O)[O-].Fc1cccc(CBr)c1>>CC1c2ccc(OCc3cccc(F)c3)cc2C2CNCC12",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.NN.O.O=C1c2ccccc2C(=O)N1Cc1cc(-c2cnc(C(F)(F)F)nc2)ncn1>>NCc1cc(-c2cnc(C(F)(F)F)nc2)ncn1",
        "output": "242"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)C(=O)c1ccc(OC)cc1-c1ncccc1C.ClCCl.O=C(OO)c1cccc(Cl)c1>>CCN(CC)C(=O)c1ccc(OC)cc1-c1c(C)ccc[n+]1[O-]",
        "output": "262"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)S(=O)(=O)Cl.CCN(C(C)C)C(C)C.C[C@H]1COCCN1c1nc(-c2cnc(N)nc2)c2c(n1)N(C1CNC1)CC2.Cl.Cl.ClCCl>>CC(C)S(=O)(=O)N1CC(N2CCc3c(-c4cnc(N)nc4)nc(N4CCOC[C@@H]4C)nc32)C1",
        "output": "584"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)c1ccccc1CN1CN(c2ccc(F)cc2)C2(CCN(CCCN3C(=O)C4(CC4)c4ccccc43)CC2)C1=O.CC[SiH](CC)CC.Cl.O=CO>>O=C(O)c1ccccc1CN1CN(c2ccc(F)cc2)C2(CCN(CCCN3C(=O)C4(CC4)c4ccccc43)CC2)C1=O",
        "output": "752"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCO.Cl.Fc1ccc(-c2nc3ccc(Cl)nn3c2-c2ccnnc2)cc1.c1ccc(CN2CC3CNCC3C2)cc1>>Fc1ccc(-c2nc3ccc(N4CC5CN(Cc6ccccc6)CC5C4)nn3c2-c2ccnnc2)cc1",
        "output": "406"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CC[SiH](CC)CC.Fc1cccc(OCC2CO2)c1OCc1ccccc1.[Pd]>>Oc1c(F)cccc1OCC1CO1",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CC2(CCN(C(=O)NC3C4CC5CC(C4)CC3C5)CC2)c2ccccc21.ClCCl.O=C(O)C(F)(F)F>>O=C(NC1C2CC3CC(C2)CC1C3)N1CCC2(CC1)CNc1ccccc12",
        "output": "830"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.CC[C@@H](CO)Nc1nc(-c2cc(Cl)cc(OC)c2)c2c(N)c(C(N)=O)sc2n1.ClCCl.O=C([O-])O.[Na+]>>CC[C@@H](CO)Nc1nc(-c2cc(O)cc(Cl)c2)c2c(N)c(C(N)=O)sc2n1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COCCOC.Cc1c(N)cccc1Br.O.O=C([O-])[O-].OB(O)c1ccc(C(F)(F)F)cc1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1c(N)cccc1-c1ccc(C(F)(F)F)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "B.C1CCOC1.O=C(O)C1(c2ccc(Cl)cc2)CC1>>OCC1(c2ccc(Cl)cc2)CC1",
        "output": "231"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C(O)CCC(=O)Nc1ccc(Br)cn1.O=S(Cl)Cl.OCCCC(F)(F)F>>O=C(CCC(=O)OCCCC(F)(F)F)Nc1ccc(Br)cn1",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C1C(C=C(C)C)C1(C)C.[Na+].[OH-]>>CC(C)=CC1C(C(=O)O)C1(C)C",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrP(Br)Br.C1COCCO1.CCOC(C)=O.O=S(=O)([O-])O.OCc1cccc(C(F)(F)F)c1Cl.[Na+]>>FC(F)(F)c1cccc(CBr)c1Cl",
        "output": "300"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.C[Si](C)(C)C#Cc1cc(N)ccc1F.O=C([O-])[O-].[K+].[K+]>>C#Cc1cc(N)ccc1F",
        "output": "337"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=O)c1cccc(Br)c1.CC[SiH](CC)CC.O=C(O)C(F)(F)F>>CCCc1cccc(Br)c1",
        "output": "92"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)c1cc(C(=O)O)no1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.C[C@H](CN)n1ccc(-c2cc(F)c(C#N)c(F)c2)n1.On1nnc2ccccc21>>CC(=O)c1cc(C(=O)NC[C@@H](C)n2ccc(-c3cc(F)c(C#N)c(F)c3)n2)no1",
        "output": "696"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1cc(O)cc(C(C)(C)C)c1.CN(C)C=O.FCCBr.O.[H-].[Na+]>>CC(=O)c1cc(OCCF)cc(C(C)(C)C)c1",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=C=O.Oc1cc(Cl)ccc1Cl.[K+].[OH-]>>O=C(O)c1c(Cl)ccc(Cl)c1O",
        "output": "387"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Cc1cc(C)nc(N2CC3CN(C(=O)c4cccnc4-c4ccnn4C4CCCCO4)CC3C2)n1.Cl.O.[Na+].[OH-]>>Cc1cc(C)nc(N2CC3CN(C(=O)c4cccnc4-c4ccn[nH]4)CC3C2)n1",
        "output": "689"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCN1C(=O)C(C)(C)c2cc3nc(-c4nn(COCC[Si](C)(C)C)c5cc(Br)ccc45)n(COCC[Si](C)(C)C)c3cc21.CN(C)C=O.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCN1C(=O)C(C)(C)c2cc3nc(-c4nn(COCC[Si](C)(C)C)c5cc(B6OC(C)(C)C(C)(C)O6)ccc45)n(COCC[Si](C)(C)C)c3cc21",
        "output": "934"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)OC(=O)/N=N/C(=O)OC(C)C.Cc1ccccc1.O.O=C1NC(=O)c2ccccc21.OC[C@@H]1CC[C@@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C1c2ccccc2C(=O)N1C[C@@H]1CC[C@@H](Nc2nccc(-n3nnc4ccccc43)n2)CC1",
        "output": "420"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1cc(Cl)cc(Cl)c1.O=C(O)c1cc(F)ccc1O>>O=C(Nc1cc(Cl)cc(Cl)c1)c1cc(F)ccc1O",
        "output": "50"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(CC(=O)N2C[C@H](O)C[C@H]2C(=O)O)on1.F[P-](F)(F)(F)(F)F.NCc1ccc(Cl)cc1>>Cc1cc(CC(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(Cl)cc2)on1",
        "output": "797"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrP(Br)Br.CCCOc1ccc(CO)cc1OC.CCOCC>>CCCOc1ccc(CBr)cc1OC",
        "output": "300"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COC(=O)C1CCNCC1.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[K+].[K+]>>COC(=O)C1CCN(c2ccc([N+](=O)[O-])cc2)CC1",
        "output": "26"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(N)c(N)cc1C.Cc1cc2nc(-c3ccc([N+](=O)[O-])cc3)[nH]c2cc1C.O=C(O)c1ccc([N+](=O)[O-])cc1.O=P(Cl)(Cl)Cl>>Cc1cc2nc(-c3ccc(N)cc3)[nH]c2cc1C",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(O)ccc3N2)c(O)c2ccccc21.CN(C)C=O.Cl.O=C(CBr)c1cccnc1.[H-].[Na+]>>CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(OCC(=O)c4cccnc4)ccc3N2)c(O)c2ccccc21",
        "output": "221"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.Cc1ccc(-c2cc(NC(=O)c3cc([N+](=O)[O-])n(C4CCCCO4)n3)nn2C2CCCCO2)cc1.[Pd]>>Cc1ccc(-c2cc(NC(=O)c3cc(N)n(C4CCCCO4)n3)nn2C2CCCCO2)cc1",
        "output": "684"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.NCCCCN1CCCN(c2csc3cc(F)ccc23)CC1.O=C(Cl)c1ccc2ccccc2c1.c1ccncc1>>O=C(NCCCCN1CCCN(c2csc3cc(F)ccc23)CC1)c1ccc2ccccc2c1",
        "output": "271"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CCCC(Cc1c[nH]c2ccccc12)N(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.CCOCC.O.[K+].[OH-]>>CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCCC(=O)O)Cc1c[nH]c2ccccc12",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrBr.CCCCCC.CCOCC.Cc1ccccc1.O=C(O)C(F)(F)F.O=C(O)c1ccccc1CCc1ccccc1.O=S=O>>O=C(O)c1ccccc1CCc1ccc(Br)cc1",
        "output": "98"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC1(C)Cc2c(c(C(=O)O)cc3nc(Nc4c(Cl)cncc4Cl)[nH]c23)O1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[B-](F)(F)F.NC1CCCCC1>>CC1(C)Cc2c(c(C(=O)NC3CCCCC3)cc3nc(Nc4c(Cl)cncc4Cl)[nH]c23)O1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)NCCOc1cccc(C=O)c1.CC(=O)[O-].CO.Cl.Cl.[BH3-]C#N.[Na+].[Na+].c1cc2[nH]ncc2cc1N[C@@H]1CCCNC1>>CC(=O)NCCOc1cccc(CN2CCC[C@@H](Nc3ccc4[nH]ncc4c3)C2)c1",
        "output": "567"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1nnc(-c2cc(C(=O)OC)c(CC)cc2C2CCC2)[nH]1.CO.O.[Na+].[OH-]>>CCc1nnc(-c2cc(C(=O)O)c(CC)cc2C2CCC2)[nH]1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(N2CCC3(CC2)CCN(C2CCC2)CC3)nc1>>CNC(=O)c1ccc(N2CCC3(CC2)CCN(C2CCC2)CC3)nc1",
        "output": "674"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc2ccccc2cc1C(=O)O.Cc1noc([C@H](N)Cc2ccc(-c3ccc(F)c(Cl)c3)cc2)n1>>COc1cc2ccccc2cc1C(=O)N[C@H](Cc1ccc(-c2ccc(F)c(Cl)c2)cc1)c1nc(C)no1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NC1CCN(CC2Cn3c(=O)ccc4ncc(F)c2c43)CC1.ClCCl.O=C(O)C(F)(F)F>>NC1CCN(CC2Cn3c(=O)ccc4ncc(F)c2c43)CC1",
        "output": "538"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.COc1c(Cc2c[nH]nn2)ccn(-c2ccccc2)c1=O.ClCCl>>O=c1c(O)c(Cc2c[nH]nn2)ccn1-c1ccccc1",
        "output": "424"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC1(C2CCC(N)CC2)OCCO1.O.O=C(Cl)OCC1c2ccccc2-c2ccccc21.O=C([O-])[O-].[Na+].[Na+]>>CC1(C2CCC(NC(=O)OCC3c4ccccc4-c4ccccc43)CC2)OCCO1",
        "output": "94"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.CC(C)(C)c1ccc2c(c1)Cc1cc(C(C)(C)C)ccc1-2.[Fe]>>CC(C)(C)c1ccc2c(c1)Cc1cc(C(C)(C)C)cc(Br)c1-2",
        "output": "98"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(C#N)cc(N)c1C#CCC(O)(CC(C)(C)c1cc(S(C)(=O)=O)cc2c1OCC2)C(F)(F)F.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1cc(C#N)cc(NC(=O)C(F)(F)F)c1C#CCC(O)(CC(C)(C)c1cc(S(C)(=O)=O)cc2c1OCC2)C(F)(F)F",
        "output": "106"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.COC(=O)c1cc(C2CC2)c(-c2ccc(F)cc2F)c(Cl)c1OC.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[H-].[Na+].[Na+]>>COc1c(CO)cc(C2CC2)c(-c2ccc(F)cc2F)c1Cl",
        "output": "444"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCC.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.OC[C@@H]1CO1.c1ccncc1>>O=S(=O)(OC[C@@H]1CO1)C(F)(F)F",
        "output": "582"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cc1cccc(-c2nc(COc3ccc(CO)cc3OC)c(C)o2)c1.Cc1ccccc1.O=C([O-])O.O=S(Cl)Cl.[Na+]>>CCOC(=O)Cc1cccc(-c2nc(COc3ccc(CCl)cc3OC)c(C)o2)c1",
        "output": "81"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(N2C(=O)N([C@@H](C)c3ccccc3)c3nc(Cl)ncc3C2C)cc1.Cc1ccccc1.Nc1ccccc1>>COc1ccc(N2C(=O)N([C@@H](C)c3ccccc3)c3nc(Nc4ccccc4)ncc3C2C)cc1",
        "output": "808"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cncc(-n2c(C)ccc2-c2cc(Br)ccc2O)c1.CCOC(C)=O.CN(C)C=O.Clc1ccc(CBr)cc1.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cncc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(Cl)cc2)c1",
        "output": "127"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(CCc1ccc2ccc(OC)cc2n1)OCC.O.O=C(O)C(F)(F)F>>COc1ccc2ccc(CCC=O)nc2c1",
        "output": "409"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1ccc2nn(Cc3ccc(Cl)c(Cl)c3)c(=O)n2c1.CO.Cl.ClCCl.O.O.[Li+].[OH-]>>O=C(O)c1ccc2nn(Cc3ccc(Cl)c(Cl)c3)c(=O)n2c1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Clc1ccnc(Cl)n1.NC1CCOC1>>Clc1nccc(NC2CCOC2)n1",
        "output": "166"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)COc1ccccc1CN1CCC2(CCNCC2)CC1.CN(C)C=O.ClCCl.N=C=N.O.O=C(O)CN(CC(=O)O)c1ccccc1>>CC(C)COc1ccccc1CN1CCC2(CC1)CCN(C(=O)CN(CC(=O)O)c1ccccc1)CC2",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=C(NC(CO)C(=O)N1CCN(CCCc2ccccc2)CC1)OCc1ccccc1.[Pd]>>NC(CO)C(=O)N1CCN(CCCc2ccccc2)CC1",
        "output": "128"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CNCCc1ccc(Oc2ccc(C(N)=O)cn2)cc1.ClCCCl.O=C([O-])O.O=Cc1ccccc1.[Na+].[Na+]>>CN(CCc1ccc(Oc2ccc(C(N)=O)cn2)cc1)Cc1ccccc1",
        "output": "567"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cc(C(=O)Nc2ccc(S(C)(=O)=O)cc2)c(C)n1-c1ccccc1C(=O)O.N>>Cc1cc(C(=O)Nc2ccc(S(C)(=O)=O)cc2)c(C)n1-c1ccccc1C(N)=O",
        "output": "358"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(Cl)cc1-c1cc(Cl)nc(N)n1.Nc1ccc2cn[nH]c2c1>>Cc1ccc(Cl)cc1-c1cc(Nc2ccc3cn[nH]c3c2)nc(N)n1",
        "output": "161"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(CC)(c1ccc(OCC(O)C(C)(C)C)c(C)c1)c1cc(C)c(C(=O)O)s1.CCN(CC)CC.CCN=C=NCCCN(C)C.CS(=O)(=O)CCN.ClCCl.On1nnc2ccccc21>>CCC(CC)(c1ccc(OCC(O)C(C)(C)C)c(C)c1)c1cc(C)c(C(=O)NCCS(C)(=O)=O)s1",
        "output": "736"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1ccc2nc(-c3ccc4scnc4c3)c(N3CCC[C@@H]3C)nc2c1.O.[Na+].[OH-]>>C[C@H]1CCCN1c1nc2cc(C(=O)O)ccc2nc1-c1ccc2scnc2c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.Cc1ccc(F)cc1C1NC(=O)CC(c2cc(Cl)ccc2N2CCNCC2)C12C(=O)Nc1cc(Cl)ccc12>>CC(=O)N1CCN(c2ccc(Cl)cc2C2CC(=O)NC(c3cc(F)ccc3C)C23C(=O)Nc2cc(Cl)ccc23)CC1",
        "output": "369"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.ClC(Cl)(Cl)Cl.FC(F)(F)c1ccc(-c2c3ccccc3cc3ccccc23)cc1.O=S([O-])([O-])=S.[Na+].[Na+]>>FC(F)(F)c1ccc(-c2c3ccccc3c(Br)c3ccccc23)cc1",
        "output": "98"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "OB(O)c1ccc(F)cc1.Oc1ccc(-c2nc3ccc(O)cc3c(Br)c2Cl)cc1>>Oc1ccc(-c2nc3ccc(O)cc3c(-c3ccc(F)cc3)c2Cl)cc1",
        "output": "872"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCN1CCCC1.C1CCOC1.CCN(CC)CC.COC(=O)COc1ccc(OC/C=C(/c2ccc(I)cc2)c2ccc3oc(C)cc3c2)cc1C.[Cu]I.[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccccc1>>COC(=O)COc1ccc(OC/C=C(\\c2ccc(C#CCN3CCCC3)cc2)c2ccc3oc(C)cc3c2)cc1C",
        "output": "664"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1cccc(CC(=O)O)c1.ClCCl.O=C(Cl)C(=O)Cl.c1ccncc1>>COC(=O)c1cccc(CC(=O)Cl)c1",
        "output": "56"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.OCC(F)(F)F>>Cc1ccc(S(=O)(=O)OCC(F)(F)F)cc1",
        "output": "197"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCCC(=O)O.O.[Na+].[OH-]>>CC(C)(C)OC(=O)NCCCC(=O)O",
        "output": "631"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(O)C1CCNCC1.CCn1cc(-c2cnc(F)c(C)c2)c2cc(OC)c(OC)cc2c1=O.CS(C)=O.O>>CCn1cc(-c2cnc(N3CCC(C(C)(C)O)CC3)c(C)c2)c2cc(OC)c(OC)cc2c1=O",
        "output": "756"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)I.CCC(Br)C(=O)[O-].Oc1ccc(Br)cc1Cl.Oc1ccc(Br)cc1F.[Br-]>>CC(C)Oc1ccc(Br)cc1Cl",
        "output": "318"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)N1CCc2ccc(OCC3CCN(c4ccc([N+](=O)[O-])cn4)CC3)cc2C1.CO.[C].[Pd]>>CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)N1CCc2ccc(OCC3CCN(c4ccc(N)cn4)CC3)cc2C1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H](CO)C1.CCN(CC)CC.CS(C)=O.ClCCl.[Cl-].[NH4+]>>CC(C)(C)OC(=O)N1CCC[C@H](C=O)C1",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1ccc(S(C)(=O)=O)c(C2=NOC(C)C2)c1Cl.[Na+].[OH-]>>CC1CC(c2c(S(C)(=O)=O)ccc(C(=O)O)c2Cl)=NO1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cc1nc2cc(NC(=O)CCl)ccc2s1.Cc1nc2cc(OC[C@H](O)CN3CCNCC3)ccc2s1>>Cc1nc2cc(NC(=O)CN3CCN(C[C@@H](O)COc4ccc5sc(C)nc5c4)CC3)ccc2s1",
        "output": "340"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Nc1cccc([N+](=O)[O-])c1.O=C1c2ccccc2COc2cc(F)ccc21.[H-].[Na+]>>O=C1c2ccccc2COc2cc(Nc3cccc([N+](=O)[O-])c3)ccc21",
        "output": "609"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=CC1(c2ccccc2)CCCC1.[BH4-].[Na+]>>OCC1(c2ccccc2)CCCC1",
        "output": "223"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N[C@H]1COCC[C@H]1N.CCN(C(C)C)C(C)C.ClCCl.Cn1cc(NC(=O)c2csc3cnc(Cl)nc23)cn1>>Cn1cc(NC(=O)c2csc3cnc(N[C@@H]4CCOC[C@@H]4NC(=O)OC(C)(C)C)nc23)cn1",
        "output": "544"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(=O)c1nn(C(=O)OC(C)(C)C)c2cc(Br)ccc12.CCOC(C)=O.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)c1nn(C(=O)OC(C)(C)C)c2cc(B3OC(C)(C)C(C)(C)O3)ccc12",
        "output": "934"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(C)=O.N#Cc1cc2c(Oc3ccc(NC(=O)NC4CC4)c(F)c3)ccnc2cc1OCC1CCNCC1.[Na+].[Na+].[OH-]>>CN1CCC(COc2cc3nccc(Oc4ccc(NC(=O)NC5CC5)c(F)c4)c3cc2C#N)CC1",
        "output": "217"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Nc1cccc2c3c([nH]c12)C=C(OCc1ccccc1)C=CC3.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>CNc1cccc2c3c([nH]c12)C=C(OCc1ccccc1)C=CC3",
        "output": "881"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1NCCc2ncc(Br)cc21.O=C(O)c1cc2ncc(Br)cn2n1>>CN1c2cc(Br)cnc2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "995"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)CC1CCCN(C(=O)c2ccc(NC(=O)COc3ccccc3)cc2)c2ccccc21.CSC.Cl.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(O)CC1CCCN(C(=O)c2ccc(NC(=O)COc3ccccc3)cc2)c2ccccc21",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCCCc1ccccc1.O=C(N[C@H]1CCNC1)C12CC3CC(CC(C3)C1)C2>>O=C(N[C@H]1CCN(CCCc2ccccc2)C1)C12CC3CC(CC(C3)C1)C2",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.Cn1c(C2CC(=O)C2)nc2ccc(-n3ccc(OCc4ccc(F)cc4)cc3=O)cc21.[BH4-].[Na+]>>Cn1c(C2CC(O)C2)nc2ccc(-n3ccc(OCc4ccc(F)cc4)cc3=O)cc21",
        "output": "91"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CC2(CCN1)OCCO2.CC(=O)O.CC(C)(C)O.CC(C)(C)P(c1ccccc1-c1[c-]cccc1)C(C)(C)C.CC(C)(C)[O-].COc1cc(Br)ccc1Cl.Cc1ccccc1.[Na+].[Pd]>>COc1cc(N2CCC3(CC2)OCCO3)ccc1Cl",
        "output": "294"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCBr.CC#N.O=C([O-])[O-].O=C([O-])[O-].OC1(c2cc(F)cc(F)c2)CCNC1.[K+].[K+].[Na+].[Na+]>>C=CCN1CCC(O)(c2cc(F)cc(F)c2)C1",
        "output": "252"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "N#Cc1ccc(Oc2cc(Oc3ccc(C#N)cc3)cc(C(=O)O)c2)cc1.NC1CCC(O)CC1>>N#Cc1ccc(Oc2cc(Oc3ccc(C#N)cc3)cc(C(=O)NC3CCC(O)CC3)c2)cc1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.N#Cc1ccc(N)cc1.O=[N+]([O-])c1cnccc1Cl.[NH4+].[OH-]>>N#Cc1ccc(Nc2ccncc2[N+](=O)[O-])cc1",
        "output": "115"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nc1ccc(Cl)c(Cl)c1.O=S(=O)(Cl)c1ccccc1.c1ccncc1>>O=S(=O)(Nc1ccc(Cl)c(Cl)c1)c1ccccc1",
        "output": "68"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.COC(=O)c1ccc(OCCN)cc1.ClC(Cl)Cl.O=C(O)c1ccc(Br)cc1>>COC(=O)c1ccc(OCCNC(=O)c2ccc(Br)cc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCO.COCCOc1cc(F)c(C2(O)CCNCC2)c(F)c1.Cl.Cn1ncc2c(=O)[nH]c(Cl)nc21.O>>COCCOc1cc(F)c(C2(O)CCN(c3nc4c(cnn4C)c(=O)[nH]3)CC2)c(F)c1",
        "output": "36"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1.O.O=C(Cl)c1ccccc1.[Na+].[OH-].c1ccncc1>>O=C(Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1)c1ccccc1",
        "output": "11"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.Cn1nccc1Nc1ccc2c(c1)C(=O)CC1(CCNCC1)O2.O.O.O=C(O)c1cc(-c2nnn[nH]2)cc(N2CCCC2)c1.On1nnc2ccccc21>>Cn1nccc1Nc1ccc2c(c1)C(=O)CC1(CCN(C(=O)c3cc(-c4nnn[nH]4)cc(N4CCCC4)c3)CC1)O2",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O.CC(C)COC(=O)Cl.CCOC(C)=O.CN1CCOCC1.COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C.Cl>>COC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C",
        "output": "133"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.COC(=O)Cc1cc2ccc(F)cc2c(C2CCNCC2)c1C.O.O.O=[N+]([O-])c1ccccc1CS(=O)(=O)Cl.[Cl-].[Na+]>>COC(=O)Cc1cc2ccc(F)cc2c(C2CCN(S(=O)(=O)Cc3ccccc3[N+](=O)[O-])CC2)c1C",
        "output": "584"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN=C=NCCCN(C)C.CN1CCOCC1.Cc1cccc(C[C@H](NC(=O)C(C)(C)N)B2O[C@@H]3C[C@@H]4C[C@@H](C4(C)C)[C@]3(C)O2)c1.Cl.ClCCl.O=C(O)c1ccc(Cl)cc1.On1nnc2ccccc21>>Cc1cccc(C[C@H](NC(=O)C(C)(C)NC(=O)c2ccc(Cl)cc2)B2O[C@@H]3C[C@@H]4C[C@@H](C4(C)C)[C@]3(C)O2)c1",
        "output": "718"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1c(O)c2cscc2[nH]c1=O.Cc1ccccc1.NC1CCCCC1>>O=C(NC1CCCCC1)c1c(O)c2cscc2[nH]c1=O",
        "output": "498"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(=O)(=O)Cl.ClCCl.O=C(OC1(CCO)CC1)c1ccccc1>>CS(=O)(=O)OCCC1(OC(=O)c2ccccc2)CC1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CN1CCNCC1.O=C([O-])O.O=[N+]([O-])c1cc(C(F)(F)F)ccc1CCl.[Na+]>>CN1CCN(Cc2ccc(C(F)(F)F)cc2[N+](=O)[O-])CC1",
        "output": "156"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Oc1c(C)c(C)c(O)c(C(C)=O)c1C.Cl.NOCCOc1ccc(CC2SC(=O)NC2=O)cc1>>CC(=O)Oc1c(C)c(C)c(O)c(C(C)=NOCCOc2ccc(CC3SC(=O)NC3=O)cc2)c1C",
        "output": "212"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.O=C([O-])[O-].OCCBr.Oc1ccc(Br)cc1C(F)(F)F.[K+].[K+]>>OCCOc1ccc(Br)cc1C(F)(F)F",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1n[nH]c2ccc(CO[Si](C)(C)C(C)(C)C)cc12.OB(O)c1cccc(Br)c1>>COC(=O)c1nn(-c2cccc(Br)c2)c2ccc(CO[Si](C)(C)C(C)(C)C)cc12",
        "output": "925"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.COC(C(=O)Cl)P(=O)(OC)OC.ClCCl.Cn1nc(N)cc1C(C)(C)C.O>>COC(C(=O)Nc1cc(C(C)(C)C)n(C)n1)P(=O)(OC)OC",
        "output": "527"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(c1ccc2ccccc2c1-c1cccc2ccccc12)C(C)(C)C.COc1ccc2c(Cl)ccnc2c1.Cc1ccccc1.O=C([O-])[O-].O=c1ncc(-c2ccccc2)cn1CCO.[Cs+].[Cs+].[Pd+2]>>COc1ccc2c(OCCn3cc(-c4ccccc4)cnc3=O)ccnc2c1",
        "output": "651"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.CC(=O)c1ccc(F)cc1Cl.N#Cc1ccc(O)cc1Cl.O.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1ccc(Oc2ccc(C#N)c(Cl)c2)cc1Cl",
        "output": "564"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NC1CCC(F)(F)CC1.O=C(O)C(F)(F)F>>NC1CCC(F)(F)CC1",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)C(=O)Nc1ncccc1C=O.CO.NC1CCN(Cc2ccccc2)CC1.[BH4-].[Na+]>>CC(C)(C)C(=O)Nc1ncccc1CNC1CCN(Cc2ccccc2)CC1",
        "output": "441"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(CN)CC1.ClCCl.Nc1cc(-c2cccs2)ccc1[N+](=O)[O-].O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)N1CCC(CNC(=O)Nc2cc(-c3cccs3)ccc2[N+](=O)[O-])CC1",
        "output": "914"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)COc1cccc(CN(Cc2ccc(C(C)(C)CO[Si](C)(C)C(C)(C)C)cc2)S(=O)(=O)c2cccnc2)c1.CCCC[N+](CCCC)(CCCC)CCCC.ClCCl.O.[F-]>>CC(C)(C)OC(=O)COc1cccc(CN(Cc2ccc(C(C)(C)CO)cc2)S(=O)(=O)c2cccnc2)c1",
        "output": "708"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2ccc3cc(O)ccc3c2)CC1.Cc1cccc(C)n1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1CCC(c2ccc3cc(OS(=O)(=O)C(F)(F)F)ccc3c2)CC1",
        "output": "731"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCc2c(n(CCN)c3ccccc23)CC1.CCN(C(C)C)C(C)C.O=C(Cl)c1ccccc1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CC(C)(C)OC(=O)N1CCc2c(n(CCNC(=O)c3ccccc3)c3ccccc23)CC1",
        "output": "271"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COc1cc2ncnc(Cl)c2cc1OC.O.O=C([O-])[O-].Oc1ccc(I)cc1.[K+].[K+]>>COc1cc2ncnc(Oc3ccc(I)cc3)c2cc1OC",
        "output": "890"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1csc(CC)c1.O.[K+].[OH-]>>CCc1cc(C(=O)O)cs1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C1CCN(c2ccc(N)cc2)C1.O=C(O)c1ccc(Br)o1>>CN(C)C1CCN(c2ccc(NC(=O)c3ccc(Br)o3)cc2)C1",
        "output": "860"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.NN.O.O=[N+]([O-])c1ccc2c(ccn2CCN2CCCCC2)c1.[Ni]>>Nc1ccc2c(ccn2CCN2CCCCC2)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1C(=O)OCCc2cc(N)ccc21.CNC(=O)c1cccc(C)c1Nc1nc(Cl)ncc1Cl>>CNC(=O)c1cccc(C)c1Nc1nc(Nc2ccc3c(c2)CCOC(=O)N3C)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=C1N(CCC)C(=O)OC12CCN(C(=O)OCc1ccccc1)CC2.CO.NN.O.[Pd]>>C=C1N(CCC)C(=O)OC12CCNCC2",
        "output": "428"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCOC(=O)c1sc2c(ccc(=O)n2-c2ccccc2[N+](=O)[O-])c1-c1ccccc1.O.O.[Li+].[OH-]>>O=C(O)c1sc2c(ccc(=O)n2-c2ccccc2[N+](=O)[O-])c1-c1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCC(c2c[nH]c3ccc(Cl)cc23)CC1.O=C(Cl)c1ccccc1>>CN1CCC(c2cn(C(=O)c3ccccc3)c3ccc(Cl)cc23)CC1",
        "output": "232"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "NNc1cc(=O)nc[nH]1.NNc1cc(O)ncn1.O=C1CCN(Cc2ccccc2)CC1>>Oc1cc(NN=C2CCN(Cc3ccccc3)CC2)ncn1",
        "output": "285"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1cnc2c(c1)OCCN(C(=O)OC(C)(C)C)C2.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>COC(=O)c1cnc2c(c1)OCCNC2",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCOC(=O)CCCCBr.COC(=O)c1ccc(CNCCc2ccccc2OC)cc1.O=C([O-])[O-].[Na+].[Na+]>>CCOC(=O)CCCCN(CCc1ccccc1OC)Cc1ccc(C(=O)OC)cc1",
        "output": "722"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Cl.COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CNC2Cc3ccccc3C2)c1>>COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CN(C(C)=O)C2Cc3ccccc3C2)c1",
        "output": "240"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1sc2cc(OCCCCBr)ccc2c1-c1ccc(Br)cc1.[N-]=[N+]=[N-].[Na+]>>Cc1sc2cc(OCCCCN=[N+]=[N-])ccc2c1-c1ccc(Br)cc1",
        "output": "622"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.CNC1CCOCC1.O=C(O)c1ccc2nsnc2c1.On1nnc2ccccc21>>CN(C(=O)c1ccc2nsnc2c1)C1CCOCC1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOP(=O)(C#N)OCC.COC(=O)C(N)Cc1cscn1.Cl.Cl.O=C(N[C@@H](Cc1cccc2ccccc12)C(=O)O)OCc1ccccc1>>COC(=O)C(Cc1cscn1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)OCc1ccccc1",
        "output": "129"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#Cc1ccc2ccccc2c1.CN(C)C=O.COc1cc(Cc2cnc(N)nc2N)cc(I)c1OC.O.O=C([O-])[O-].[Cu]I.[K+].[K+].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc(Cc2cnc(N)nc2N)cc(C#Cc2ccc3ccccc3c2)c1OC",
        "output": "664"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)COc1c(-c2ccccc2)cc([N+](=O)[O-])cc1-c1ccccc1.[Br-].[K+]>>O=C(O)COc1c(-c2ccccc2)cc([N+](=O)[O-])cc1-c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)N1CCN(c2ccc([N+](=O)[O-])cc2)C(=O)C1.CCCCCC.CCOCC.CO.Cc1ccccc1.[H][H].[Pd]>>CC(C)N1CCN(c2ccc(N)cc2)C(=O)C1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.ClCCl.Cn1cc(-c2cccc(-n3ncc4cc(C(C)(C)C)ccc4c3=O)c2C=O)cc(Nc2ccc(C(=O)N3CCOCC3)cn2)c1=O.[BH4-].[Na+]>>Cn1cc(-c2cccc(-n3ncc4cc(C(C)(C)C)ccc4c3=O)c2CO)cc(Nc2ccc(C(=O)N3CCOCC3)cn2)c1=O",
        "output": "356"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1cc(F)cc([N+](=O)[O-])c1.Cl[Sn]Cl>>CCOC(=O)c1cc(N)cc(F)c1",
        "output": "481"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=O.CC(=O)O.CC1CN(C(=O)c2cc3cc(Cl)ccc3[nH]2)CCN1.ClCCl.[Na]>>CC1CN(C(=O)c2cc3cc(Cl)ccc3[nH]2)CCN1C",
        "output": "217"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)n1ncc(-c2nc(CC(=O)N3CCSCC3)cs2)c1-c1ccc(F)cc1.CO.O.O=S([O-])OO.[K+]>>CC(C)(C)n1ncc(-c2nc(CC(=O)N3CCS(=O)(=O)CC3)cs2)c1-c1ccc(F)cc1",
        "output": "847"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.COc1cc(N2CCC(=O)CC2)ccc1[N+](=O)[O-].ClCCl.O=C([O-])O.OC1CCCNC1.[Na+]>>COc1cc(N2CCC(N3CCCC(O)C3)CC2)ccc1[N+](=O)[O-]",
        "output": "187"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCC(=O)c1cc(C)ccc1O.CCO.COS(=O)(=O)OC.[Na+].[OH-]>>CCCCCCC(=O)c1cc(C)ccc1OC",
        "output": "317"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N1CCNCC1.O=C(Nc1ccc(OCCN2CCOCC2)c2ccccc12)c1ccnc(Cl)c1>>CC(=O)N1CCN(c2cc(C(=O)Nc3ccc(OCCN4CCOCC4)c4ccccc34)ccn2)CC1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COCCc1nc2cnc3ccccc3c2n1CCCCCC(=O)N1CCOCC1.Cc1ccc(S(=O)(=O)Cl)cc1.O=C(OO)c1cccc(Cl)c1.[NH4+].[OH-]>>COCCc1nc2c(N)nc3ccccc3c2n1CCCCCC(=O)N1CCOCC1",
        "output": "959"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(CNc2nc3c(C(=O)O)cccc3[nH]2)CC1.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.COCCN.Cl.O.O.On1nnc2ccccc21>>COCCNC(=O)c1cccc2[nH]c(NCC3CCN(C(=O)OC(C)(C)C)CC3)nc12",
        "output": "674"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CNC(=O)c1ccc(-c2cc(C)c([N+](=O)[O-])cc2C(C)C)cc1.CO.[Pd]>>CNC(=O)c1ccc(-c2cc(C)c(N)cc2C(C)C)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(C)=O.CN(C)c1ccncc1.CN(C)c1ccncc1.O=[N+]([O-])c1ccc2[nH]nc(I)c2c1.[Cl-].[NH4+]>>CC(C)(C)OC(=O)n1nc(I)c2cc([N+](=O)[O-])ccc21",
        "output": "841"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.O=C(Nc1ccc(Br)cc1)Nc1cc(C(F)(F)F)ccc1Oc1ccccc1C(=O)[O-].OC(c1ccccc1)c1ccccc1.[Pd]>>O=C(Nc1ccc(Br)cc1)Nc1cc(C(F)(F)F)ccc1Oc1ccccc1C(=O)O",
        "output": "151"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Nc1cnc(Oc2cnc3ccccc3c2)c(Cl)c1.O=S(=O)(Cl)c1ccc(Cl)cc1F>>O=S(=O)(Nc1cnc(Oc2cnc3ccccc3c2)c(Cl)c1)c1ccc(Cl)cc1F",
        "output": "554"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCOC(=O)C1(Sc2ccnc3ccc(Br)cc23)CCC1.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccccc1F.[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)C1(Sc2ccnc3ccc(-c4ccccc4F)cc23)CCC1",
        "output": "837"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCOC(=O)c1nc(-c2ccc(NC(=O)Oc3ccccc3)cc2)nc(N2CCOCC2)c1OCC.CN>>CCOC(=O)c1nc(-c2ccc(NC(=O)NC)cc2)nc(N2CCOCC2)c1OCC",
        "output": "488"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN[C@@H](C)CO.Oc1ccc(Nc2ncnc3cccc(F)c23)cc1Cl>>CN[C@@H](C)COc1cccc2ncnc(Nc3ccc(O)c(Cl)c3)c12",
        "output": "958"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1cc(NC(=O)Oc2ccccc2)n(-c2ccccc2)n1.CCN(C(C)C)C(C)C.CN(C)c1ccncc1.COCCOc1cc2ncnc(Oc3cccc(N)c3)c2cc1OC>>COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccccc4)c3)c2cc1OC",
        "output": "948"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CO.Cl.O=C(O)[C@@H]1CC[C@H](O)CN1>>COC(=O)[C@@H]1CC[C@H](O)CN1",
        "output": "195"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1c(C(F)(F)F)c(C2CC2)nn1C.Cn1nc(OC(F)F)cc1C(=O)O>>Cn1nc(C2CC2)c(C(F)(F)F)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCC(CC(=O)OCC)n1ccc2cc(CCCc3ccc4c(n3)NCCC4)ccc21.Cl.O.[Na+].[OH-]>>CCCC(CC(=O)O)n1ccc2cc(CCCc3ccc4c(n3)NCCC4)ccc21",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.Cc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(Cc4ncccc4O)cc2)CCO3)cc1.O=C(OO)c1cccc(Cl)c1.O=S([O-])([O-])=S.[Na+].[Na+]>>Cc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(Cc4c(O)ccc[n+]4[O-])cc2)CCO3)cc1",
        "output": "262"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.COc1ccc(C(=O)Cl)cc1.ClCCl.NCc1cc(-c2ccccc2)no1>>COc1ccc(C(=O)NCc2cc(-c3ccccc3)no2)cc1",
        "output": "271"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cncnc1O.CO.O.[Li]O>>O=C(O)c1cncnc1O",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CN(C)CCC(CO)c1ccc(Cl)c(Cl)c1.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CN(C)CCC(C=O)c1ccc(Cl)c(Cl)c1",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.COCCCc1cc(CNC2CC2)c(Cl)cn1.Cc1cc(Cl)c(OCCOc2ccc(CC(C#N)C(=O)O)cn2)c(Cl)c1.Cl.ClC(Cl)Cl.ClCCl.On1nnc2ccccc21>>COCCCc1cc(CN(C(=O)C(C#N)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)nc2)C2CC2)c(Cl)cn1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)[C@@H]1CC[C@H](Nc2nc(C)cc(N(C)C)n2)CC1.Cl.O.[K+].[OH-]>>Cc1cc(N(C)C)nc(N[C@@H]2CC[C@H](C(=O)O)CC2)n1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Clc1ncccn1.O=Cc1c[nH]cn1.[H-].[Na+]>>O=Cc1cn(-c2ncccn2)cn1",
        "output": "788"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCBr.COC(=O)c1ccc(O)c([N+](=O)[O-])c1>>CCCCOc1ccc(C(=O)OC)cc1[N+](=O)[O-]",
        "output": "385"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(N)ccc3N2)c(O)c2cccnc21.ClC(Cl)Cl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(NC(=O)C(F)(F)F)ccc3N2)c(O)c2cccnc21",
        "output": "106"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.COC(=O)c1c(Cc2ccccc2)c(=O)c2ccc(C)nc2n1-c1cccc([N+](=O)[O-])c1>>COC(=O)c1c(Cc2ccccc2)c(=O)c2ccc(C)nc2n1-c1cccc(N)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COc1cc(C(=O)N2CC(C)NC(=O)C2CC(N)=O)cc2nc(NCc3cc(Cl)ccn3)oc12.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>COc1cc(C(=O)N2CC(C)NC(=O)C2CC#N)cc2nc(NCc3cc(Cl)ccn3)oc12",
        "output": "172"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@H](O)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(-c5ccn[nH]5)cc4)ccc3n2)CC1.O=C(O)C1(O)CC1.c1cc(-c2ccc(Oc3ccc4nc(CN5CCNCC5)ccc4c3)cc2)[nH]n1>>O=C(N1CCN(Cc2ccc3cc(Oc4ccc(-c5ccn[nH]5)cc4)ccc3n2)CC1)C1(O)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(C)=O.COc1ccc(C=O)cn1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1ccc(CO)cn1",
        "output": "476"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)/C=C/c1ccc(Oc2c(-c3ccc(OC)cc3)sc3cc(OC)ccc23)cc1.ClCCl.O.[Li+].[OH-]>>COc1ccc(-c2sc3cc(OC)ccc3c2Oc2ccc(/C=C/C(=O)O)cc2)cc1",
        "output": "58"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCS(=O)(=O)Cl.Cc1cccc(C)c1N.Cc1ccccc1>>CCCS(=O)(=O)Nc1c(C)cccc1C",
        "output": "194"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)COc1ccc(Cl)c2nc(C)c(Cc3ccc(Cl)cc3)c(OC(F)F)c12.O.[Li+].[OH-]>>Cc1nc2c(Cl)ccc(OCC(=O)O)c2c(OC(F)F)c1Cc1ccc(Cl)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNCC1.Cc1ccccc1.O.O=C(O)c1ccccc1.O=C1CSC(=O)N1.O=Cc1ccc(-c2ccccc2Cl)cc1>>O=C1NC(=O)C(=Cc2ccc(-c3ccccc3Cl)cc2)S1",
        "output": "761"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)CNCC(C)C.CCO.O=C(c1ccccc1)c1ccc(Cl)c([N+](=O)[O-])c1>>CC(C)CN(CC(C)C)c1ccc(C(=O)c2ccccc2)cc1[N+](=O)[O-]",
        "output": "105"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)C1(NC(=O)c2cc(CO)cc(C)c2OC2CCC2)Cc2ccccc2C1.O.[K+].[OH-]>>Cc1cc(CO)cc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1OC1CCC1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.C=Cc1cnc2cc(-c3ccccc3)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)nn12.Cl>>C=Cc1cnc2cc(-c3ccccc3)c(-c3ccc(C4(N)CCC4)cc3)nn12",
        "output": "793"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.ClCCl.O=C(OCc1ccccc1)N1CCC(CO)CC1.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>O=CC1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O.COC(=O)c1cccc(Cn2nc(-c3cccc(CCO)c3)ccc2=O)c1.CS(=O)(=O)Cl>>COC(=O)c1cccc(Cn2nc(-c3cccc(CCOS(C)(=O)=O)c3)ccc2=O)c1",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.NCC(N)=O.O=C(O)CCCOc1cc(CNc2nc3ccccc3n2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)ccc1-c1ccccc1.On1nnc2ccccc21>>NC(=O)CNC(=O)CCCOc1cc(CNc2nc3ccccc3n2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)ccc1-c1ccccc1",
        "output": "133"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(C)(CC)C(=O)Cl.C[C@H]1C=CC2=CCC[C@H](O)[C@@H]2[C@H]1CC[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CC(=O)O1>>CCC(C)(CC)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O[Si](C)(C)C(C)(C)C)CC(=O)O3)[C@H]21",
        "output": "126"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CS(C)=O.C[C@@H]1CC(O)c2ncnc(N3CCN(C(=O)OC(C)(C)C)CC3)c21.ClCCl.O.O=C(Cl)C(=O)Cl>>C[C@@H]1CC(=O)c2ncnc(N3CCN(C(=O)OC(C)(C)C)CC3)c21",
        "output": "456"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cccc(CC(=O)Cl)c1.Nc1ccc(F)cc1>>COc1cccc(CC(=O)Nc2ccc(F)cc2)c1",
        "output": "9"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CC1(c2ccc(OCc3cccc(-c4c(C)cc(OCC5CCS(=O)(=O)CC5)cc4C)c3)cc2)COC1.CO.[Li+].[OH-]>>Cc1cc(OCC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(C3(CC(=O)O)COC3)cc2)c1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1cnc(NCc2ccncc2)nc1NC1CCN(Cc2ccccc2)CC1.OB(O)c1ccc(Cl)cc1.c1ccc(CN2CCC(Nc3nc(NCc4ccccn4)ncc3-c3ccsc3)CC2)cc1>>Clc1ccc(-c2cnc(NCc3ccncc3)nc2NC2CCN(Cc3ccccc3)CC2)cc1",
        "output": "871"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N(Cc1ccc2c(c1)OCCO2)C1CCNCC1.Cc1cc(=O)n(CC=O)c2cc(F)ccc12.ClC(Cl)Cl.ClCCl.O.O=C([O-])O.[Na+].[Na+]>>Cc1cc(=O)n(CCN2CCC(N(Cc3ccc4c(c3)OCCO4)C(=O)OC(C)(C)C)CC2)c2cc(F)ccc12",
        "output": "484"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCNCC3)C2=O)c1.O=C(CCCI)c1ccc(F)cc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCN(CCCC(=O)c4ccc(F)cc4)CC3)C2=O)c1",
        "output": "184"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CCC(C)=O.Cc1ccc(S(=O)(=O)[O-])cc1.Cc1ccccc1.OCCO.c1cc[nH+]cc1>>CCOC(=O)CCC1(C)OCCO1",
        "output": "265"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1c(-c2ccc(N3CCNCC3)nc2)nc2cc(F)cc(F)c2c1Cl.Cc1ccccc1.Nc1cncc(N2CCOCC2)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1c(-c2ccc(N3CCNCC3)nc2)nc2cc(F)cc(F)c2c1Nc1cncc(N2CCOCC2)c1",
        "output": "859"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.O=C1CCc2cc(C(=O)CCl)ccc2N1.OC1(c2ccc(Cl)s2)CCNCC1>>O=C1CCc2cc(C(=O)CN3CCC(O)(c4ccc(Cl)s4)CC3)ccc2N1",
        "output": "414"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(C)N=C=O.Cc1cc(N2C(=O)N(CCCCCCCCCSCCCC(F)(F)C(F)(F)F)C(C)(C)C2=O)ccc1N.ClCCCl.O>>CCC(C)NC(=O)Nc1ccc(N2C(=O)N(CCCCCCCCCSCCCC(F)(F)C(F)(F)F)C(C)(C)C2=O)cc1C",
        "output": "176"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC1CCCC(CC)N1C[C@@H](O)CN1C(=O)c2ccccc2C1=O.CCO.NN.O>>CCC1CCCC(CC)N1C[C@@H](O)CN",
        "output": "242"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC1CCNCC1.CN(C)C=O.COc1ccc2c(n1)N(CC1CO1)C(=O)CC2>>COc1ccc2c(n1)N(CC(O)CN1CCC(NC(=O)OC(C)(C)C)CC1)C(=O)CC2",
        "output": "76"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)S(=O)(=O)n1c(N)nc2ccc(-c3nc(-c4ccc([N+](=O)[O-])cc4F)[nH]c3-c3ccccc3)cc21.CCO.O=C[O-].[NH4+].[Pd]>>CC(C)S(=O)(=O)n1c(N)nc2ccc(-c3nc(-c4ccc(N)cc4F)[nH]c3-c3ccccc3)cc21",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)C(C)Oc1cccc(SCCCn2cc(C(c3ccccc3)c3ccccc3)ccc2=O)c1.ClCCl.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)C(C)Oc1cccc(S(=O)CCCn2cc(C(c3ccccc3)c3ccccc3)ccc2=O)c1",
        "output": "500"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCCCC(=O)c1ccc(O)c(C(=O)O)c1.ClP(Cl)Cl.Clc1ccccc1.Nc1ccc([N+](=O)[O-])cc1>>CCCCCCCCCC(=O)c1ccc(O)c(C(=O)Nc2ccc([N+](=O)[O-])cc2)c1",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(-n2ccc3cc(OC)cc(C#N)c3c2=O)cc1.O=C1CCC(=O)N1Br>>COc1ccc(-n2cc(Br)c3cc(OC)cc(C#N)c3c2=O)cc1",
        "output": "518"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1CNCC(C)N1.CS(C)=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[K+].[K+]>>CC1CN(c2ccc([N+](=O)[O-])cc2)CC(C)N1",
        "output": "26"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1cc(NC(=O)c2cc(F)c(F)cc2C)[nH]n1.Cl.O.[Na+].[OH-]>>Cc1cc(F)c(F)cc1C(=O)Nc1cc(C(=O)O)n[nH]1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)CN.CCN(C(C)C)C(C)C.CCN1CC(C)(C)OC(=O)C1CC(=O)O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F>>CCN1CC(C)(C)OC(=O)C1CC(=O)NCC(C)C",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(CC=C2Cc3ccc(C(=O)O)cc3C2=O)CC1.CCOC(C)=O.CI.CO.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)c1ccc2c(c1)C(=O)C(=CCC1CCN(C(=O)OC(C)(C)C)CC1)C2",
        "output": "415"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1.COc1ccc2c(c1)c(C(=O)CCCCCBr)cn2C.Cl.Cl>>COc1ccc2c(c1)c(C(=O)CCCCCN1CCC(CNC(=O)c3cc(Cl)c(N)cc3OC)CC1)cn2C",
        "output": "73"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(OCC(=O)N2CCCC2)CC1>>CC(C)(C)OC(=O)N1CCC(OCCN2CCCC2)CC1",
        "output": "112"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrP(Br)Br.CC(C)Cc1ccc(CO)cc1.c1ccccc1>>CC(C)Cc1ccc(CBr)cc1",
        "output": "300"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=P(c1ccccc1)(c1ccccc1)c1ccc(Br)cc1.OB(O)c1ccc2c(-c3ccc4ccccc4c3)c3ccccc3c(-c3ccc4ccccc4c3)c2c1>>O=P(c1ccccc1)(c1ccccc1)c1ccc(-c2ccc3c(-c4ccc5ccccc5c4)c4ccccc4c(-c4ccc5ccccc5c4)c3c2)cc1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC)S(=O)(=O)CCCCCCCl.Clc1ccc(C(c2ccccc2)N2CCNCC2)cc1>>CCN(CC)S(=O)(=O)CCCCCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.COC(=O)Nc1ccc(CCOc2ccc(C=C3SC(=O)NC3=O)cc2)cc1.[Pd]>>COC(=O)Nc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)cc1",
        "output": "762"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cnc2c(C(F)(F)F)cccc2c1-c1cccc(O)c1.Cl.ClCCl.O=C([O-])[O-].OCCc1ccc(CBr)cc1.[Cs+].[Cs+]>>Cc1cnc2c(C(F)(F)F)cccc2c1-c1cccc(OCc2ccc(CCO)cc2)c1",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.C[C@H]1CN(c2nnc(-c3ccccc3)c3ccccc23)CCN1.O=S(=O)(Cl)c1ccccc1>>C[C@H]1CN(c2nnc(-c3ccccc3)c3ccccc23)CCN1S(=O)(=O)c1ccccc1",
        "output": "99"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C1CCNCC1.O=C1c2c(-c3ccc(F)cc3)cc(Cl)nc2OCCCN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CN(C)C1CCN(c2cc(-c3ccc(F)cc3)c3c(n2)OCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)CC1",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCC2=NCCCN2CC1.CCCc1c(OCCCOc2cccc3c2CCCC3)ccc2c1OC(CCC(=O)O)(CCC(=O)O)CC2=O.CCI.CN(C)C=O>>CCCc1c(OCCCOc2cccc3c2CCCC3)ccc2c1OC(CCC(=O)O)(CCC(=O)OCC)CC2=O",
        "output": "196"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Oc1ccc([N+](=O)[O-])cc1.[C].[Pd]>>Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Oc1ccc(N)cc1",
        "output": "335"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "OCC1CCOC1.Oc1cccc(F)c1Nc1nc(Cl)ncc1Cl>>Fc1cccc(OCC2CCOC2)c1Nc1nc(Cl)ncc1Cl",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CN(C2CCCC2)c2nc(Cl)ncc2N(C)C1=O.CCO.COc1cc(C(=O)O)ccc1N.Cl.O>>COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(C)C(=O)N2C",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NC(=O)C(O)C(N)Cc1ccccc1.O=C(O)[C@H]1CCC(=O)N1Cc1ccccc1.On1nnc2ccccc21>>NC(=O)C(O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1ccccc1",
        "output": "216"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCn1c(COC)nc2c(N)nc3ccc(O)cc3c21.CN(C)C=O.ClCCl.O=C(CBr)N1CCOCC1.O=C([O-])[O-].[Cs+].[Cs+]>>CCCn1c(COC)nc2c(N)nc3ccc(OCC(=O)N4CCOCC4)cc3c21",
        "output": "778"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCCNCC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N[C@@H]1CCCC[C@H]1C=O.ClCCl.O.[Na+].[Na+].[OH-]>>CC(C)(C)OC(=O)N[C@@H]1CCCC[C@H]1CN1CCCCCC1",
        "output": "484"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.COc1cc(-n2nc(Cl)cc2-c2ccc(S(C)(=O)=O)cc2)ccc1[N+](=O)[O-].NN.O>>COc1cc(-n2nc(Cl)cc2-c2ccc(S(C)(=O)=O)cc2)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CC1CC1.CC(C)(C)[Si](C)(C)OC1CCC(Nc2ccccc2I)CC1.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>CC(C)(C)[Si](C)(C)OC1CCC(Nc2ccccc2C#CC2CC2)CC1",
        "output": "664"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCCCCC[C@H](NC(=O)c1cnc(C)cn1)C(=O)O.C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2nc3ccccc3c3ccccc23)CN1)C(=O)OCC.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)CCN.Cl.O=C1C2C3C=CC(C3)C2C(=O)N1O>>C=CCCCCC[C@H](NC(=O)c1cnc(C)cn1)C(=O)N1C[C@H](Oc2nc3ccccc3c3ccccc23)C[C@H]1C(=O)N[C@]1(C(=O)OCC)C[C@H]1C=C",
        "output": "297"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1c(C=O)[nH]c2c1C(=O)N(CCN1CCCC1)CCC2.O=C1Cc2cc(F)cc(Br)c2N1>>Cc1c(/C=C2\\C(=O)Nc3c(Br)cc(F)cc32)[nH]c2c1C(=O)N(CCN1CCCC1)CCC2",
        "output": "911"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc2c(Cl)nc(C#N)c(-c3ccccc3F)c2c1.COc1ccc2c(NCCO)nc(C#N)c(-c3cccc(F)c3)c2c1.NCC(O)CO>>COc1ccc2c(NCC(O)CO)nc(C#N)c(-c3ccccc3F)c2c1",
        "output": "70"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1ccc(N2CCC(=O)CC2)c(Br)n1.O.O=C([O-])[O-].[Cl-].[K+].[K+].[NH3+]O>>COc1ccc(N2CCC(=NO)CC2)c(Br)n1",
        "output": "86"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Cl.ClCCl.NCC1C=C2C=COCC3=C2B(OC3)O1>>CC(C)(C)OC(=O)NCC1C=C2C=COCC3=C2B(OC3)O1",
        "output": "631"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C([O-])[O-].O=Cc1ccccc1O.[K+].[K+]>>O=Cc1ccccc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)[C@@H]1COCCN1c1cc(-c2cc(F)c(C#N)c(F)c2)nc(N)n1.CN(C)C=O.C[O-].Cc1ccccc1.[Na+]>>COc1cc(-c2cc(N3CCOC[C@H]3C(C)C)nc(N)n2)cc(F)c1C#N",
        "output": "485"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC)CCN.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CNc1ccc(C(=O)O)cc1.F[B-](F)(F)F.O=C([O-])[O-].On1nnc2ccccc21.[Na+].[Na+]>>CCN(CC)CCNC(=O)c1ccc(NC)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)C(C)(C)CCCC=O.COC([O-])[O-].NCc1ccccc1>>COC(=O)C(C)(C)CCCCNCc1ccccc1",
        "output": "627"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1cc2ccc(C(=O)NCCc3ccccn3)cc2[nH]1.Cl.O.[K+].[OH-]>>O=C(NCCc1ccccn1)c1ccc2cc(C(=O)O)[nH]c2c1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.Cc1ccc([N+](=O)[O-])cc1O.ClCCl.OB(O)c1ccc(OC(F)(F)F)cc1.[Cu+2]>>Cc1ccc([N+](=O)[O-])cc1Oc1ccc(OC(F)(F)F)cc1",
        "output": "920"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.C[C@H]1COC[C@H](C)N1.ClCCl.O=Cc1ccc(Br)c(F)c1.[Na+]>>C[C@H]1COC[C@H](C)N1Cc1ccc(Br)c(F)c1",
        "output": "567"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)CCOS(C)(=O)=O.CN(C)C=O.N#Cc1cc(Br)ccc1O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)CCOc1ccc(Br)cc1C#N",
        "output": "702"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.OCCOCCO>>Cc1ccc(S(=O)(=O)OCCOCCO)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc2nc(C#N)ccc2c1.O=C1CCC(=O)N1Br>>N#Cc1ccc2cc(CBr)ccc2n1",
        "output": "29"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCO.CCOC(=O)CC(=O)c1ccc(Cl)c(OCC(F)(F)F)c1.Cc1ccc(S(=O)(=O)O)cc1.Cc1cnc(-c2cn[nH]c2N)o1>>Cc1cnc(-c2cnn3c(=O)cc(-c4ccc(Cl)c(OCC(F)(F)F)c4)[nH]c23)o1",
        "output": "513"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.CCN(CC)CC.CCOC(=O)Cl.COC(=O)[C@H](C)N.Cl>>COC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C",
        "output": "129"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.COc1cc2ccc(-c3cc4c(cc3[N+](=O)[O-])OCO4)cc2cc1OC.[Pd]>>COc1cc2ccc(-c3cc4c(cc3N)OCO4)cc2cc1OC",
        "output": "202"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCc1nc(-c2cc3ccccc3o2)cs1.CO.O=C([O-])[O-].[K+].[K+].[Na+].[OH-]>>O=C(O)CCc1nc(-c2cc3ccccc3o2)cs1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.ClCCl.Fc1cc2[nH]ccc2cc1OCc1ccccc1>>CC(C)(C)OC(=O)n1ccc2cc(OCc3ccccc3)c(F)cc21",
        "output": "748"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(N2CCN(c3cnccc3C)C2=O)cc1.ClCCl.O.[Li+].[OH-]>>Cc1ccncc1N1CCN(c2ccc(C(=O)O)cc2)C1=O",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCS(=O)(=O)c1ccc(Cl)c(C#N)c1.O=C(O)Cc1ccc(Cl)c(O)c1>>CCS(=O)(=O)c1ccc(Oc2cc(CC(=O)O)ccc2Cl)c(C#N)c1",
        "output": "299"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCCCc1nc(N)c2c(n1)c(C#CCCCCl)cn2COCc1ccccc1.CCN(CC)CC.C[C@H]1CCCN1.ClCCl>>CCCCc1nc(N)c2c(n1)c(C#CCCCN1CCC[C@@H]1C)cn2COCc1ccccc1",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#Cc1c(F)c(F)cc2c(=O)c(C(=O)OCC)cn(C3CC3)c12.CC(=O)O.O.O=S(=O)(O)O>>C#Cc1c(F)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)c1cc(Cl)cc2c1O[C@@H]1CCCC[C@H]21.O.[Na+].[OH-]>>O=C(O)c1cc(Cl)cc2c1O[C@@H]1CCCC[C@H]21",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CS(=O)(=O)N1CC=C(c2cc3c(cn2)O[C@@H](C2CCNCC2)C3)CC1.Clc1cnc(Cl)nc1>>CS(=O)(=O)N1CC=C(c2cc3c(cn2)O[C@@H](C2CCN(c4ncc(Cl)cn4)CC2)C3)CC1",
        "output": "36"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cc(Cn2c(C)c(-c3ccc(C#N)cc3)c(C#N)c2C(C)C)cnc1Cl.O=C(O)CC(O)(CC(=O)O)C(=O)O.[BH4-].[Ca+2].[Cl-].[Cl-].[Na+]>>Cc1c(-c2ccc(C#N)cc2)c(C#N)c(C(C)C)n1Cc1cnc(Cl)c(CO)c1",
        "output": "383"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC)CCN.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C1NC(=S)SC1=Cc1ccc(-c2ccc(Cl)c(C(=O)O)c2)o1>>CCN(CC)CCNC(=O)c1cc(-c2ccc(C=C3SC(=S)NC3=O)o2)ccc1Cl",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "NCc1cccc(Cl)c1.O=C(O)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1>>O=C(NCc1cccc(Cl)c1)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1",
        "output": "753"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(C)=O.CNC(=O)c1c(-c2ccc(Cl)cc2)oc2cc(N(c3ccc(OCc4ccccc4)c(F)c3)S(C)(=O)=O)c(C3CC3)cc12.[Pd]>>CNC(=O)c1c(-c2ccc(Cl)cc2)oc2cc(N(c3ccc(O)c(F)c3)S(C)(=O)=O)c(C3CC3)cc12",
        "output": "698"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.Cc1ccc(S(=O)(=O)O)cc1.NCCCCCCc1ccc(F)cc1F.O=C(O)CN1C(=O)CC1SCc1ccccc1>>O=C(CN1C(=O)CC1SCc1ccccc1)NCCCCCCc1ccc(F)cc1F",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1[nH]c2cc(OC)c(OC)cc2c1Sc1ccccc1C.CCOC(C)=O.CO.Cl.[Li+].[OH-]>>COc1cc2[nH]c(C(=O)O)c(Sc3ccccc3C)c2cc1OC",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCN(c2ccc(-c3c(CO)nc4ccccn34)cn2)CC1.ClC(Cl)Cl.[Mn+4].[O-2].[O-2]>>CN1CCN(c2ccc(-c3c(C=O)nc4ccccn34)cn2)CC1",
        "output": "287"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)Cc1cc(S)n2ncnc2n1.Cl.O.[K+].[OH-]>>O=C(O)Cc1cc(S)n2ncnc2n1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)c1ccc(N=C=O)cc1.CCn1cc(-c2cccc(N)c2)c(-c2ccncc2)n1.ClCCl>>CCn1cc(-c2cccc(NC(=O)Nc3ccc(C(C)C)cc3)c2)c(-c2ccncc2)n1",
        "output": "473"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.C[O-].Cc1cnc(Cl)c(Br)c1.[Na+]>>COc1ncc(C)cc1Br",
        "output": "433"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N[C@@H](Cc1ccc(N2CC(=O)NS2(=O)=O)c(OCc2ccccc2)c1)C(=O)O.COC(=O)c1c(OCCCCN)cccc1OCc1ccccc1>>COC(=O)c1c(OCCCCNC(=O)[C@H](Cc2ccc(N3CC(=O)NS3(=O)=O)c(OCc3ccccc3)c2)NC(C)=O)cccc1OCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1c(OC)cccc1C(=O)c1cc(Cl)ccc1N.CO.[BH4-].[Na+]>>CCc1c(OC)cccc1C(O)c1cc(Cl)ccc1N",
        "output": "157"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CN(CCCO)C(=O)OC(C)(C)C.ClCCl.O=C([O-])O.[Na+]>>CN(CCC=O)C(=O)OC(C)(C)C",
        "output": "142"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1onc(-c2cccc(Cl)c2)c1COc1ccc(C(=O)O)cn1.F[B-](F)(F)F.NCC(F)(F)F>>Cc1onc(-c2cccc(Cl)c2)c1COc1ccc(C(=O)NCC(F)(F)F)cn1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.COc1cc(F)c(C(O)Cc2cc(Br)ccc2[N+](=O)[O-])c(Cl)c1.ClCCl>>COc1cc(F)c(C(=O)Cc2cc(Br)ccc2[N+](=O)[O-])c(Cl)c1",
        "output": "32"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CNCCN1.Clc1nc(N2CCOCC2)c2ncnc(SC3CCCCC3)c2n1>>c1nc(SC2CCCCC2)c2nc(N3CCNCC3)nc(N3CCOCC3)c2n1",
        "output": "36"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.CN(c1cccc(NC(=O)c2cccc(C(C)(C)C#N)c2)c1)c1ncc2nc(NC(=O)CCl)sc2n1.O=C([O-])O.O=S1(=O)CCNCC1.[Na+]>>CN(c1cccc(NC(=O)c2cccc(C(C)(C)C#N)c2)c1)c1ncc2nc(NC(=O)CN3CCS(=O)(=O)CC3)sc2n1",
        "output": "340"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "B1C2CCCC1CCC2.C1CCOC1.C=CCc1cc(Cl)c(OCCOc2ccc(CC(CNC(=O)OC(C)(C)C)C(=O)N(Cc3cc(CCCOC)ccc3Cl)C3CC3)cc2)c(Cl)c1.CCOC(C)=O.OO.[Na+].[OH-]>>COCCCc1ccc(Cl)c(CN(C(=O)C(CNC(=O)OC(C)(C)C)Cc2ccc(OCCOc3c(Cl)cc(CCCO)cc3Cl)cc2)C2CC2)c1",
        "output": "465"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2cc(=O)cc(N3CCOCC3)o2)c2c1Cc1ccccc1S2.ClCCl.O=C(O)C(F)(F)F>>Nc1ccc(-c2cc(=O)cc(N3CCOCC3)o2)c2c1Cc1ccccc1S2",
        "output": "782"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CCOC(=O)c1cn([C@@H]2C[C@@H]2F)c2c(OC)c(F)cc(N)c2c1=O.Cl.O>>COc1c(F)cc(N)c2c(=O)c(C(=O)O)cn([C@@H]3C[C@@H]3F)c12",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.NCC1CCCCC1.O=C(O)c1cc(CCO)n2cccc(Cl)c12.On1nnc2ccccc21>>O=C(NCC1CCCCC1)c1cc(CCO)n2cccc(Cl)c12",
        "output": "674"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1CCCO1.Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(B2OC(C)(C)C(C)(C)O2)c1.ClCCl.Cl[Pd]Cl.Fc1cncc(Br)c1.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cncc(F)c2)c1",
        "output": "938"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)CC1.CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O=S(=O)(O)O>>Cc1ccc(S(=O)(=O)OC2CCN(C(=O)OC(C)(C)C)CC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOCC.COC(=O)c1cc(-n2cnnn2)ccc1C.O.O.[Li+].[OH-]>>Cc1ccc(-n2cnnn2)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)C(CC)Cc1ccc(OC)c(CC(=O)Nc2ccc(C(F)(F)F)cc2)c1.Cl.[Na+].[OH-]>>CCC(Cc1ccc(OC)c(CC(=O)Nc2ccc(C(F)(F)F)cc2)c1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)Cc1ccc(C(C)C(=O)Cl)cc1.CCN(CC)CC.O.OCc1cccc(F)c1>>CC(C)Cc1ccc(C(C)C(=O)OCc2cccc(F)c2)cc1",
        "output": "126"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.O.O.O=C(O)CCCCCNC(=O)COc1ccccc1.O=[N+]([O-])c1cccc(S(=O)(=O)CCO)c1.c1ccccc1>>O=C(COc1ccccc1)NCCCCCC(=O)OCCS(=O)(=O)c1cccc([N+](=O)[O-])c1",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(Oc1ccc(S(C)(=O)=O)cc1C(=O)O)C(F)(F)F.Cl.FC(F)(F)c1cnc(N2CCNCC2)s1>>CC(C)(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ncc(C(F)(F)F)s2)CC1)C(F)(F)F",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CNC(=O)c1cc(Cl)ccn1.ClC(Cl)Cl.Nc1cccc2cc(O)ccc12.[H-].[Na+]>>CNC(=O)c1cc(Oc2ccc3c(N)cccc3c2)ccn1",
        "output": "351"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=Cc1ccc(OC)c([N+](=O)[O-])c1.CC(=O)O.ClCCl.[Zn]>>C=Cc1ccc(OC)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1sc(-c2cc3cccc(NS(=O)(=O)c4cccs4)c3[nH]2)nc1C.CO.[Na+].[OH-]>>Cc1nc(-c2cc3cccc(NS(=O)(=O)c4cccs4)c3[nH]2)sc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1nc(NC(=O)c2c(F)cccc2F)sc1-c1cccc(C(F)(F)F)c1.Cl.[Na+].[OH-]>>O=C(O)c1nc(NC(=O)c2c(F)cccc2F)sc1-c1cccc(C(F)(F)F)c1",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.COC(=O)c1ncccc1-c1ccc(Cl)c(C(=O)O)c1.ClCCl.NCC1(O)CCCCCC1.O=C(Cl)C(=O)Cl>>COC(=O)c1ncccc1-c1ccc(Cl)c(C(=O)NCC2(O)CCCCCC2)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=C(OCc1ccccc1)N1CCN(C(=O)c2ccc(-c3nc4ccc(F)cc4o3)cc2)C2(CC2)C1.[Pd]>>O=C(c1ccc(-c2nc3ccc(F)cc3o2)cc1)N1CCNCC12CC2",
        "output": "428"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)Nc4cnc(-c5cccc(Cl)c5)nc4)cc3)c(Cl)cc21.CCOC(C)=O.Cl.[Na+].[OH-]>>O=C(Nc1cnc(-c2cccc(Cl)c2)nc1)c1ccc(Oc2cc3c(cc2Cl)C(C(=O)O)CCO3)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NCc1ccc(C(=O)Nc2ccccc2N)cc1.O=C(O)c1cccc2cc(Oc3ccnc4cc(Cl)ccc34)ccc12>>Nc1ccccc1NC(=O)c1ccc(CNC(=O)c2cccc3cc(Oc4ccnc5cc(Cl)ccc45)ccc23)cc1",
        "output": "753"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "N#CCCC1CCc2ccccc2O1.O=C(O)C(F)(F)F.O=[N+]([O-])[O-].[Na+]>>N#CCCC1CCc2cc([N+](=O)[O-])ccc2O1",
        "output": "103"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc([N+](=O)[O-])c4)cc3)c2cc1OC.[C].[OH-].[OH-].[Pd+2]>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(N)c4)cc3)c2cc1OC",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CC(=O)O)C(=O)OCc1ccccc1.CCO.CCOC(C)=O.CN(C)c1ccncc1.ClCCCl.ClCCl.O=C([O-])O.[Na+]>>CCOC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1",
        "output": "47"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1cc2ccc3c(=O)[nH]nc(Cl)c(n1)c23.O=C([O-])O.[Na+].c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2cc3ccc4c(=O)[nH]nc(Cl)c(n2)c34)[C@](C)(O)[C@@H]1O",
        "output": "193"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Cl)c(CN3CCNCC3)c(C(F)(F)F)cc2c1=O.ClCCl.O=C1COC1>>CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Cl)c(CN3CCN(C4COC4)CC3)c(C(F)(F)F)cc2c1=O",
        "output": "983"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cnc(CNC(=O)OC(C)(C)C)c2c(OC)cc(OC)cc12.CCOC(C)=O.Cl.O.O.[Li]O>>COc1cc(OC)c2c(CNC(=O)OC(C)(C)C)ncc(C(=O)O)c2c1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)C(=O)Cl.ClCCl.Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1>>CC(C)(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1",
        "output": "9"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCCC1=O.COCCN.Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(OCc2cccc(Br)n2)cc1>>COCCNc1cccc(COc2ccc(C(=O)Nc3cc(C(=O)NC4CC4)ccc3C)cc2)n1",
        "output": "715"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1cc(Cl)nc(N)n1.Oc1ccc(Cl)cc1Cl.[K+].[OH-]>>Nc1cc(Oc2ccc(Cl)cc2Cl)nc(N)n1",
        "output": "668"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCn1c(=O)c(-c2ccccc2S(C)(=O)=O)cc2cnc(SC)nc21.ClCCl.O=C(OO)c1cccc(Cl)c1>>CCn1c(=O)c(-c2ccccc2S(C)(=O)=O)cc2cnc(S(C)=O)nc21",
        "output": "595"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(=O)(=O)c1ccc(Cl)c(C#N)c1.O=C(O)Cc1ccc(Cl)c(O)c1>>CS(=O)(=O)c1ccc(Oc2cc(CC(=O)O)ccc2Cl)c(C#N)c1",
        "output": "299"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.O=c1oc2cc(O)ccc2c2ccc([N+](=O)[O-])cc12.[Pd]>>Nc1ccc2c(c1)c(=O)oc1cc(O)ccc12",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc([C@@H](C)CNC(=O)OC(C)(C)C)cc1.O=C1CCC(=O)N1Br>>COc1cc(Br)c2[nH]c(=O)c3sccc3c2c1-c1ccc([C@@H](C)CNC(=O)OC(C)(C)C)cc1",
        "output": "518"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(N)[C@H]2SC1.CC(C)(C)OC(=O)CON=C(C(=O)O)c1nccc(N)n1.CCOC(C)=O.CN(C)C=O.C[Si](C)(C)CC(N)=O.ClCCl.O=P(Cl)(Cl)Cl>>C=CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)C(=NOCC(=O)OC(C)(C)C)c3nccc(N)n3)[C@H]2SC1",
        "output": "587"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cl.O=C(Cl)c1ccc(F)cc1F.c1ccc(-c2noc([C@H]3CCCNC3)n2)cc1>>O=C(c1ccc(F)cc1F)N1CCC[C@H](c2nc(-c3ccccc3)no2)C1",
        "output": "201"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NCc1ccc(N2CC(C(=O)O)OC2=O)cc1.CCOCC.Cl>>NCc1ccc(N2CC(C(=O)O)OC2=O)cc1",
        "output": "793"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.Cl.N[C@@H]1CC[C@@H](NC(=O)c2c[nH]c3c(-c4cc(F)ccc4OCC4CC4)ncnc23)CC1>>CC(=O)N[C@@H]1CC[C@@H](NC(=O)c2c[nH]c3c(-c4cc(F)ccc4OCC4CC4)ncnc23)CC1",
        "output": "45"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#C[Si](C)(C)C.C1CCOC1.CCN(CC)CC.Cc1ccc(C#N)cc1Br.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1ccc(C#N)cc1C#C[Si](C)(C)C",
        "output": "671"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)CBr.CN(C)C=O.Cl.O.Oc1ccc(O)cc1.[Na+].[OH-]>>CCOC(=O)COc1ccc(O)cc1",
        "output": "123"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)C(CC)C1CCC2(CC1)OCCO2.Cl>>CCOC(=O)C(CC)C1CCC(=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrBr.CC(C)(C)N.CCOCC.Cc1ccccc1.ClCCl.O.Oc1ccccc1OCc1ccccc1>>Oc1c(Br)cccc1OCc1ccccc1",
        "output": "98"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CNCc1cccnc1.ClCCOc1ccccc1Br>>CN(CCOc1ccccc1Br)Cc1cccnc1",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNC.Cl.ClC(Cl)Cl.F[P-](F)(F)(F)(F)F>>CN(C)C(=O)C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)CBr.CN(CCO)C(=O)c1c(-c2ccc(C(C)(C)C)cc2)n(C)n(-c2ccc(C#N)cc2)c1=O.[Cl-].[H-].[NH4+].[Na+]>>CN(CCOCC(=O)OC(C)(C)C)C(=O)c1c(-c2ccc(C(C)(C)C)cc2)n(C)n(-c2ccc(C#N)cc2)c1=O",
        "output": "669"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(O)CN.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)O)ccc21.F[P-](F)(F)(F)(F)F>>CC(O)CNC(=O)c1ccc2c(c1)nc(Nc1nc3ccc(OC(F)(F)F)cc3s1)n2C",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCc1cc(-c2ccc(C#Cc3ccncc3)cc2)no1.Fc1cccc(-c2nc3cn[nH]cc-3n2)c1F>>Fc1cccc(-c2nc3cnn(Cc4cc(-c5ccc(C#Cc6ccncc6)cc5)no4)cc-3n2)c1F",
        "output": "997"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.Nc1nc(-c2ccc(Cl)cc2)cs1.O=C(Cl)c1ccc(F)cc1.c1ccncc1>>O=C(Nc1nc(-c2ccc(Cl)cc2)cs1)c1ccc(F)cc1",
        "output": "673"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.Cc1cc(C(=O)O)n(C)n1.Nc1cccc(C(=O)c2ccc3c(c2)NC(=O)C3)c1.O=S(Cl)Cl>>Cc1cc(C(=O)Nc2cccc(C(=O)c3ccc4c(c3)NC(=O)C4)c2)n(C)n1",
        "output": "844"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc2c(C(=O)c3ccc(Cl)nc3)c(-c3ccc(OCCN4CCCC4)cc3)sc2c1.OCCN1CCCC1>>COc1ccc2c(C(=O)c3ccc(OCCN4CCCC4)nc3)c(-c3ccc(OCCN4CCCC4)cc3)sc2c1",
        "output": "433"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC2(C1)CN(C(=O)OCC[Si](C)(C)C)c1ccc(C=O)cc12.CCO.O.[BH4-].[Na+]>>CC(C)(C)OC(=O)N1CCC2(C1)CN(C(=O)OCC[Si](C)(C)C)c1ccc(CO)cc12",
        "output": "356"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OCc1nnnn1-c1ccc(C#N)c(C(F)(F)F)c1.CCO.O.[Li+].[OH-]>>N#Cc1ccc(-n2nnnc2CO)cc1C(F)(F)F",
        "output": "348"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CCC1.CCN(C(C)C)C(C)C.O=C(N1CC=C(c2cc3c(Nc4ccc5ncsc5c4)ncnc3[nH]2)CC1)N1CCNCC1>>O=C(N1CC=C(c2cc3c(Nc4ccc5ncsc5c4)ncnc3[nH]2)CC1)N1CCN(CC2CCC2)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Nc1cccc(Oc2cc3c(cn2)nc(-c2nonc2N)n3-c2ccc(O)cc2)c1.O.On1nnc2ccccc21>>CC(C)C(=O)Oc1ccc(-n2c(-c3nonc3N)nc3cnc(Oc4cccc(N)c4)cc32)cc1",
        "output": "108"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COc1cccc(CN)c1.O=C(O)c1ccc2cnccc2n1>>COc1cccc(CNC(=O)c2ccc3cnccc3n2)c1",
        "output": "905"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1CCCCn1ccc(-c2cccnc2)n1>>NCCCCn1ccc(-c2cccnc2)n1",
        "output": "242"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCO/N=C(\\C(=O)OCC)c1ccc(OCCOc2ccc3ccccc3c2)s1.CO.[Na+].[OH-]>>CCO/N=C(\\C(=O)O)c1ccc(OCCOc2ccc3ccccc3c2)s1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCNc1cc(C(=O)O)cc(S(N)(=O)=O)c1Sc1ccc(NC(C)=O)cc1.[Na+].[OH-]>>CCCCNc1cc(C(=O)O)cc(S(N)(=O)=O)c1Sc1ccc(N)cc1",
        "output": "66"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(S(=O)(=O)CCOC2CCCCO2)cc1-c1cn(C)c(=O)c2ccc(-c3cnn(C)c3)cc12.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.c1cc[nH+]cc1>>COc1ccc(S(=O)(=O)CCO)cc1-c1cn(C)c(=O)c2ccc(-c3cnn(C)c3)cc12",
        "output": "543"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.O=C(O)c1ccc(NS(=O)(=O)c2cccnc2)cc1.O=S(Cl)Cl>>O=C(Cl)c1ccc(NS(=O)(=O)c2cccnc2)cc1",
        "output": "3"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CN(C)C(=O)CCl.ClCCl.O=C([O-])[O-].O=[N+]([O-])O.O=[N+]([O-])c1ccc2c(c1)CCNCC2.[Cs+].[Cs+].[Cs+].[I-]>>CN(C)C(=O)CN1CCc2ccc([N+](=O)[O-])cc2CC1",
        "output": "340"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCOC(=O)CC(c1ccccc1)n1cnc2cc(NC(=O)c3ccc([N+](=O)[O-])cc3)ccc21.Cl>>O=C(O)CC(c1ccccc1)n1cnc2cc(NC(=O)c3ccc([N+](=O)[O-])cc3)ccc21",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)C(C)(C)Oc1ccc(OCCC(C)O)cc1.CS(=O)(=O)Cl.ClCCl>>CCOC(=O)C(C)(C)Oc1ccc(OCCC(C)OS(C)(=O)=O)cc1",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCOC(C)=O.COC(=O)C1=C(C(=O)Nc2sc(C)c(C3CC3)c2-c2nc(C(F)(F)F)no2)CCC1.Cl.O>>Cc1sc(NC(=O)C2=C(C(=O)O)CCC2)c(-c2nc(C(F)(F)F)no2)c1C1CC1",
        "output": "58"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CO.COC(=O)c1cc2c([N+](=O)[O-])cccc2[nH]1.O=C[O-].[NH4+].[Pd]>>COC(=O)c1cc2c(N)cccc2[nH]1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.Cl.ClCCl.O=C(CCc1cc(O)no1)NCC1CCNCC1.O=C(Cl)OCc1cc(Cl)cc(Cl)c1.[Na+].[OH-]>>O=C(CCc1cc(O)no1)NCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1",
        "output": "427"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc(C#N)cc1.NN.O>>N#Cc1ccc(C(=O)NN)cc1",
        "output": "421"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1ccc(CNCCc2ccccc2Cl)cc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O.O=C(O)c1cccc2cc[nH]c12>>CC(C)(C)c1ccc(CN(CCc2ccccc2Cl)C(=O)c2cccc3cc[nH]c23)cc1",
        "output": "893"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.NC1CC2C=CCC(C1)C2.[C].[H][H].[Pd]>>NC1CC2CCCC(C1)C2",
        "output": "143"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)O)CC2)nc1CN1CCCCC1=O.NS(=O)(=O)Cc1ccc(F)cc1>>CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccc(F)cc3)CC2)nc1CN1CCCCC1=O",
        "output": "644"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCn4cccn4)cc2)CCN3CC(C)C)cc1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=S([O-])([O-])=S.[Na+].[Na+]>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cn4cccn4)cc2)CCN3CC(C)C)cc1",
        "output": "500"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Nc1nc(C)c(-c2ccc(S(C)(=O)=O)c(F)c2)s1.CN1CCNCC1.CS(C)=O>>CC(=O)Nc1nc(C)c(-c2ccc(S(C)(=O)=O)c(N3CCN(C)CC3)c2)s1",
        "output": "26"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCc1cc(C=O)cc(CCC)c1O[Si](C)(C)C(C)(C)C.CCOC(C)=O.CCOCC.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-].[Li]CCCC>>C=Cc1cc(CCC)c(O[Si](C)(C)C(C)(C)C)c(CCC)c1",
        "output": "649"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(C)=O.Cc1cc(C)c(CCl)c(C)c1.O.[H-].[Na+].c1ccc2[nH]ccc2c1>>Cc1cc(C)c(Cn2ccc3ccccc32)c(C)c1",
        "output": "556"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.O=C(Nc1cc([N+](=O)[O-])ccc1F)C(F)(F)F.[H][H]>>Nc1ccc(F)c(NC(=O)C(F)(F)F)c1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C.CO.COC(=O)C(=Cc1c[nH]c2cc(Cl)ccc12)NC(C)=O.Cl.O.[Na+].[OH-]>>CC(=O)NC(=Cc1c[nH]c2cc(Cl)ccc12)C(=O)O",
        "output": "58"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C[C@H]1CNC[C@@H](C)O1.O=C(O)[C@H]1CCc2c(sc3ncnc(Nc4cc5cn[nH]c5cn4)c23)C1>>C[C@H]1CN(C(=O)[C@H]2CCc3c(sc4ncnc(Nc5cc6cn[nH]c6cn5)c34)C2)C[C@@H](C)O1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1ccc(Nc2ccccc2C(=O)O)cc1Cl>>O=C(O)c1ccccc1Nc1ccc(O)c(Cl)c1",
        "output": "402"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.O.O=C1CCc2cccc(Nc3ncc(-c4ccc(C(F)(F)F)cc4)o3)c2C1.[BH4-].[Na+]>>OC1CCc2cccc(Nc3ncc(-c4ccc(C(F)(F)F)cc4)o3)c2C1",
        "output": "91"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C(CCC1CCC(=O)N1)Cc1cccc(Oc2ccccc2)c1.[BH4-].[Na+]>>O=C1CCC(CCC(O)Cc2cccc(Oc3ccccc3)c2)N1",
        "output": "91"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCSC(=O)c1cc(C#N)c(N2CCC(C(=O)O)CC2)nc1C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClCCl.F[B-](F)(F)F.NS(=O)(=O)Cc1ccccc1.O=C([O-])O.[Na+]>>CCSC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccccc3)CC2)nc1C",
        "output": "644"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COc1c(Br)cccc1-c1ccccc1.O=Cc1cccc(-c2ccccc2)c1OCc1ccccc1.[Cl-].[Li]CCCC.[NH4+]>>COc1c(-c2ccccc2)cccc1C(O)c1cccc(-c2ccccc2)c1OCc1ccccc1",
        "output": "379"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Nc1cc(Br)ccc1F.O.O=S([O-])[O-].[I-].[K+].[Na+].[Na+]>>Fc1ccc(Br)cc1I",
        "output": "200"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[O-].CC(=O)[O-].COC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1ccccc1.Cc1nnn(-c2ccc(Br)cc2)c1NC(=O)O[C@@H]1CCc2ccccc21.O.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd+2]>>COC(=O)C1(c2ccc(-c3ccc(-n4nnc(C)c4NC(=O)O[C@@H]4CCc5ccccc54)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCO.CCOc1nccc2c(Nc3c(Cl)cc(C#N)cc3Cl)nc3ccncc3c12.[Cl-].[NH3+]O>>CCOc1nccc2c(Nc3c(Cl)cc(C(N)=NO)cc3Cl)nc3ccncc3c12",
        "output": "400"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCNC3)cc1.N#Cc1cccnc1Cl>>CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(c2ncccc2C#N)C3)cc1",
        "output": "220"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNCC1.CCO.COc1ccc(-c2cccc3c2CC(=O)N3)cc1.Cc1[nH]c(C=O)c(C)c1C(=O)NCCN1CCCC1>>COc1ccc(-c2cccc3c2C(=Cc2[nH]c(C)c(C(=O)NCCN4CCCC4)c2C)C(=O)N3)cc1",
        "output": "440"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.CCN(CC)CC.CO.COc1ccc(N(C)c2nc(Cl)nc3c2CCCC3)cc1.ClCCl.ClCCl.NCCO>>COc1ccc(N(C)c2nc(NCCO)nc3c2CCCC3)cc1",
        "output": "544"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.CS(=O)(=O)Cl.ClCCl.N#N.OCc1cc(F)c(Br)cc1F>>CS(=O)(=O)OCc1cc(F)c(Br)cc1F",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)CC(C(=O)O)c1csc(-c2ccccc2)n1.CCN(CC)CC.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.N#CCN.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CC(C)CC(C(=O)NCC#N)c1csc(-c2ccccc2)n1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COB(OC)OC.COc1ccc(Br)c(C)c1.[Li]CCCC>>COc1ccc(B(O)O)c(C)c1",
        "output": "789"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@]3(CO)[C@@H]4[C@@H](CC[C@]3(O)C2)[C@@]2(O)CC[C@H](C3=CC(=O)OC3)[C@@]2(C)C[C@H]4O)[C@H](O)[C@H](O)[C@H]1O.Cc1cccc(C)c1NCC(C)O.Cl.O=C(Cl)c1ccccc1.[Na+].[OH-].c1ccccc1>>Cc1cccc(C)c1N(CC(C)O)C(=O)c1ccccc1",
        "output": "614"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.COCCN(Cc1cnc(-c2cc3nccc(Oc4ccc(N)cc4F)c3s2)n1C)C(=O)OC(C)(C)C.NC1CC1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COCCN(Cc1cnc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)n1C)C(=O)OC(C)(C)C",
        "output": "913"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C.CCOC(C)=O.CS(C)=O.Nc1ccc(I)cc1F.O=C([O-])[O-].Oc1cccc2cccnc12.[K+].[K+].[NH4+].[OH-].c1ccc(N2CCNCC2)nc1>>Nc1ccc(N2CCN(c3ccccn3)CC2)cc1F",
        "output": "931"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc(S(=O)(=O)n2c(C)c(CO)c3ccccc32)cc1.ClC(Cl)Cl.O=S(Cl)Cl>>Cc1ccc(S(=O)(=O)n2c(C)c(CCl)c3ccccc32)cc1",
        "output": "477"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1c(C)cc(N2CCOCC2)nc1C1CC1.CO.[Na+].[OH-]>>Cc1cc(N2CCOCC2)nc(C2CC2)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cl.FC(F)(F)c1cnc(Cl)c(Cl)c1.O.O=C1CCNCC1.[Cl-].[NH4+]>>O=C1CCN(c2ncc(C(F)(F)F)cc2Cl)CC1",
        "output": "220"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCBr.CC(C)=O.COc1ccc(C=O)cc1O.O=C([O-])[O-].[K+].[K+]>>C=CCOc1cc(C=O)ccc1OC",
        "output": "77"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)O.CCN=C=NCCCN(C)C.CN(C)C(=O)[C@@H]1CCCN1.Cl.ClCCl.On1nnc2ccccc21>>CN(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1csc2ccccc12)NC(=O)OC(C)(C)C",
        "output": "297"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CN)c1.Cc1csc2ncc(C(=O)O)n12>>Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2cnc3scc(C)n23)c1",
        "output": "697"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)c1cnc2nc(-c3ccccc3)c(CCCCC(=O)OC(C)(C)C)nc2c1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1cnc2nc(-c3ccccc3)c(CCCCC(=O)O)nc2c1",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.COc1ccc(C=O)c(N)c1O.c1ccncc1>>COc1ccc(C=O)c(NC(C)=O)c1O",
        "output": "6"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1cccc(-c2nc(-c3cccnc3)no2)c1.CC(C)(C)OC(=O)N1CCNCC1.CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CC(C)(C)OC(=O)N1CCN(c2cccc(-c3nc(-c4cccnc4)no3)c2)CC1",
        "output": "294"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc2cnccc2c1.CN(C)C=O.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3cccc(B4OC(C)(C)C(C)(C)O4)c3)cc12.Cl[Pd]Cl.O=P([O-])([O-])[O-].[Fe+2].[K+].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3cccc(-c4ccc5cnccc5c4)c3)cc12",
        "output": "933"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1nc2c(C(F)(F)F)cc(Br)cn2c1Cl.O=C1COC(=O)N1C1CCNCC1>>O=C(c1nc2c(C(F)(F)F)cc(Br)cn2c1Cl)N1CCC(N2C(=O)COC2=O)CC1",
        "output": "729"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cc1ccc(C#N)cc1[N+](=O)[O-].[H][H].[Pd]>>Cc1ccc(C#N)cc1N",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc2[nH]c(C(=O)NC(C)C)c(C)c2c1.CS(C)=O.Cc1c(C(=O)NC(C)C)[nH]c2ccc(O)cc12.ClCCl.O=C([O-])[O-].O=[N+]([O-])c1cc(Cl)c(F)c(Cl)c1.[K+].[K+]>>Cc1c(C(=O)NC(C)C)[nH]c2ccc(Oc3c(Cl)cc([N+](=O)[O-])cc3Cl)cc12",
        "output": "564"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)Cc1nc(-c2ccc(-c3ccccc3F)nc2)sc1C.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1sc(-c2ccc(-c3ccccc3F)nc2)nc1CCO",
        "output": "225"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.COC1=C(OC)C(=O)C2=C(CCC(CCO)CC2)C1=O.Cc1ccc(O)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC1=C(OC)C(=O)C2=C(CCC(CCOc3ccc(C)cc3)CC2)C1=O",
        "output": "478"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)c1ccc(O)c(C(F)(F)F)c1.CI.CN(C)C=O.O.[H-].[Na+]>>COc1ccc(C(C)=O)cc1C(F)(F)F",
        "output": "62"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cc(F)ccc1B(O)O.Fc1ncccc1OCc1cn2cc(Br)cnc2n1>>Cc1cc(F)ccc1-c1cnc2nc(COc3cccnc3F)cn2c1",
        "output": "871"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.O.O=CN1CCNCC1.O=[N+]([O-])c1ccccc1Cl>>O=CN1CCN(c2ccccc2[N+](=O)[O-])CC1",
        "output": "105"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)CNC(=O)c1ccc2nc(N3CCC(OCc4c(-c5ccccc5OC(F)(F)F)noc4C4CC4)CC3)sc2c1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li+].[OH-]>>O=C(O)CNC(=O)c1ccc2nc(N3CCC(OCc4c(-c5ccccc5OC(F)(F)F)noc4C4CC4)CC3)sc2c1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "B.C1CCOC1.C1CCOC1.Cl.N#Cc1cc(O)cc(OCc2ccccc2)c1.O=C([O-])O.[Na+]>>NCc1cc(O)cc(OCc2ccccc2)c1",
        "output": "175"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.CSc1cc(CN)nc(SC)n1>>CSc1cc(CNC(C)=O)nc(SC)n1",
        "output": "339"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.Cc1ccccc1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.O=C(NCCO)OCc1ccccc1.Oc1ccc(-n2cccn2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(NCCOc1ccc(-n2cccn2)cc1)OCc1ccccc1",
        "output": "550"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.CN(C)C=O.N#Cc1cccc(CBr)c1.O=C([O-])[O-].O=Cc1ccc(OCc2cccc(-c3ccc4c(c3)OCCO4)c2Cl)cc1O.[Cs+].[Cs+]>>N#Cc1cccc(COc2cc(OCc3cccc(-c4ccc5c(c4)OCCO5)c3Cl)ccc2C=O)c1",
        "output": "127"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1sc2ncnc(Nc3ccc(F)cc3O[C@@H]3CCCN(C(=O)OC(C)(C)C)C3)c2c1C.[Na+].[OH-]>>Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3O[C@@H]3CCCN(C(=O)OC(C)(C)C)C3)c12",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1cc(C(=O)O)cc([N+](=O)[O-])c1OC.ClCCl.O=C(Cl)C(=O)Cl>>COc1cc(C(=O)Cl)cc([N+](=O)[O-])c1OC",
        "output": "448"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrB(Br)Br.CCc1cc(OC)c(Oc2ccc(C(=O)N3CC(=O)NC(=O)C3)cc2F)cc1F.ClCCl.[Cl-].[NH4+]>>CCc1cc(O)c(Oc2ccc(C(=O)N3CC(=O)NC(=O)C3)cc2F)cc1F",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)Cc1ccc(N)cc1.Fc1cc(Cl)cc(-c2cc(Cl)c3c(n2)CCC3)c1>>CCOC(=O)Cc1ccc(Nc2cc(-c3cc(F)cc(Cl)c3)nc3c2CCC3)cc1",
        "output": "115"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(CCN)cc1OC.Cc1cccc(OCC2CO2)c1>>COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC",
        "output": "16"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CI.CN(C)C=O.Cc1cc(C)cc(Oc2ccc(O)cc2S(=O)(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c1.O=C([O-])[O-].[K+].[K+]>>COc1ccc(Oc2cc(C)cc(C)c2)c(S(=O)(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c1",
        "output": "62"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.CN(C)C=O.O.O=C(O)c1c(Cl)ccnc1Cl.O=C([O-])[O-].[K+].[K+]>>O=C(OCc1ccccc1)c1c(Cl)ccnc1Cl",
        "output": "403"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.Clc1cccnc1Cl.O=C(O)c1ccc(B(O)O)cc1.O=C([O-])[O-].[Na+].[Na+]>>O=C(O)c1ccc(-c2ncccc2Cl)cc1",
        "output": "865"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C1CCNCC1.Clc1ccnc2ccc(Br)cc12>>CCOC(=O)C1CCN(c2ccnc3ccc(Br)cc23)CC1",
        "output": "398"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCN=C=O.Oc1ccc2c(c1)CCN2Cc1ccccc1>>CCCNC(=O)Oc1ccc2c(c1)CCN2Cc1ccccc1",
        "output": "104"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(SCc2cccc([N+](=O)[O-])c2)c1.CCO.Cl.O.[Cl-].[Fe].[NH4+]>>CC(C)(C)OC(=O)Nc1cccc(SCc2cccc(N)c2)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(OCc2c(-c3ccccc3)noc2C)nnc1C(=O)O.NC1CC1>>Cc1cc(OCc2c(-c3ccccc3)noc2C)nnc1C(=O)NC1CC1",
        "output": "816"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC1(C)CC2CC(C)(CN2C(=O)c2ccc3c(C#N)c[nH]c3c2)C1.OO.[Na+].[OH-]>>CC1(C)CC2CC(C)(CN2C(=O)c2ccc3c(C(N)=O)c[nH]c3c2)C1",
        "output": "677"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.ClCCl.Fc1ccc2cc[nH]c2c1>>CC(C)(C)OC(=O)n1ccc2ccc(F)cc21",
        "output": "748"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)N(C)C.CCn1cc(C(=O)O)c(C)n1.CN(C)C=O.Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)ccc1Cl.O=C(Cl)C(=O)Cl>>CCn1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2Cl)c(C)n1",
        "output": "851"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCI.CN(C)C=O.N#Cc1ccc(Oc2ccc([N+](=O)[O-])cc2)cc1O.O=C([O-])[O-].[K+].[K+]>>CCOc1cc(Oc2ccc([N+](=O)[O-])cc2)ccc1C#N",
        "output": "198"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CI.O.OCCn1cnc2cc(Br)ccc21.[H-].[Na+]>>COCCn1cnc2cc(Br)ccc21",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1ccc(-c2cc(NC(=O)OC(C)(C)C)ccc2C)cc1.[Na+].[OH-]>>Cc1ccc(NC(=O)OC(C)(C)C)cc1-c1ccc(C(=O)O)cc1",
        "output": "5"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCC(C)OC(=O)Cl.CCN.CCN1CCCCC1.C[C@H](NC(=O)OCc1ccccc1)C(=O)O>>CCNC(=O)[C@H](C)NC(=O)OCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CCBr.CC(C)=O.COC(=O)[C@H](Cc1cccc(O)c1)NC(=O)OC(C)(C)C.O.O=C([O-])[O-].[K+].[K+]>>C=CCOc1cccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)OC)c1",
        "output": "77"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.Cl.NCCN1c2ccccc2Sc2ccccc21.O=S(=O)(Cl)c1ccc(OC(F)(F)F)cc1>>O=S(=O)(NCCN1c2ccccc2Sc2ccccc21)c1ccc(OC(F)(F)F)cc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)NC1(CCC(C)(C)C)C(=O)C(C2=NS(=O)(=O)c3cc(N)ccc3N2)=C(O)c2ccccc21.CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.ClCCl>>CC(=O)NC1(CCC(C)(C)C)C(=O)C(C2=NS(=O)(=O)c3cc(NS(C)(=O)=O)ccc3N2)=C(O)c2ccccc21",
        "output": "194"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCCCCCCCOc1ccc(C=O)c2ccccc12.NCCc1ccccc1F>>CCCCCCCCCCCCOc1ccc(CNCCc2ccccc2F)c2ccccc12",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)N1C2CCC1CC(c1ccnc3c(-c4cccc(OC)c4)c(-c4ccncc4)nn13)C2.C[Si](C)(C)I.ClC(Cl)Cl>>COc1cccc(-c2c(-c3ccncc3)nn3c(C4CC5CCC(C4)N5)ccnc23)c1",
        "output": "283"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.ClCCl.Nc1ccc(-c2cc3c(cc2Cl)CCO3)cn1.O=C(Cl)c1c(F)cccc1F.O=C([O-])O.[Na+]>>O=C(Nc1ccc(-c2cc3c(cc2Cl)CCO3)cn1)c1c(F)cccc1F",
        "output": "463"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CCc1nc2cnc3ccccc3c2n1CCCCNC1CCSC1.ClCCl>>CCc1nc2cnc3ccccc3c2n1CCCCN(C(C)=O)C1CCSC1",
        "output": "369"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1nc(N)sc1C(=O)NCc1ccccc1.O=C(Cl)c1cc(Cl)ccc1F>>Cc1nc(NC(=O)c2cc(Cl)ccc2F)sc1C(=O)NCc1ccccc1",
        "output": "673"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)Cc1cccc(B2OC(C)(C)C(C)(C)O2)c1.Cc1noc(-c2ccc(Br)cc2)c1NC(=O)O[C@H](C)c1ccccc1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1>>CCOC(=O)Cc1cccc(-c2ccc(-c3onc(C)c3NC(=O)O[C@H](C)c3ccccc3)cc2)c1",
        "output": "933"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCN=C=N.CCOC(=O)C1CCC(CN)CC1.CN(C)C=O.Cl.Cl.O.O.O=C(O)c1cccnc1Oc1cccc([N+](=O)[O-])c1.On1nnc2ccccc21>>CCOC(=O)C1CCC(CNC(=O)c2cccnc2Oc2cccc([N+](=O)[O-])c2)CC1",
        "output": "674"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)S(=O)(=O)c1ccc(O)cc1.CS(C)=O.N#Cc1cc([N+](=O)[O-])ccc1Cl.O.[Na+].[OH-]>>CN(C)S(=O)(=O)c1ccc(Oc2ccc([N+](=O)[O-])cc2C#N)cc1",
        "output": "299"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(COCC(N)c2ccccc2Cl)CC1.O=C(O)c1ccc2c(Cl)c[nH]c2c1>>CC(C)(C)OC(=O)N1CCC(COCC(NC(=O)c2ccc3c(Cl)c[nH]c3c2)c2ccccc2Cl)CC1",
        "output": "753"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.O.O=[N+]([O-])c1ccc(-c2ncn(-c3ccc(C(F)(F)F)cc3)n2)cc1.[Fe]>>Nc1ccc(-c2ncn(-c3ccc(C(F)(F)F)cc3)n2)cc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)c1ccc2c(c1)CC(C)(C)C(c1cccc(N3CC(C)OC(C)C3)c1)N2.CO.Cl.O.[Na+].[OH-]>>CC1CN(c2cccc(C3Nc4ccc(C(=O)O)cc4CC3(C)C)c2)CC(C)O1",
        "output": "5"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(=O)(=O)O.O.O=C1[C@H](NS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)CC=CCN1OCc1ccccc1>>O=C1[C@H](NS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)CC=CCN1O",
        "output": "707"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(C)=O.COc1cc2c(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C)no4)c3)ncnc2cc1OCC1CCNCC1.[Na+].[Na+].[OH-]>>COc1cc2c(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C)no4)c3)ncnc2cc1OCC1CCN(C)CC1",
        "output": "217"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CN(C)C=O.CN1CCN(S(=O)(=O)CCCO)CC1.Cc1cc2nccn2nc1Cl.O.[H-].[Na+]>>Cc1cc2nccn2nc1OCCCS(=O)(=O)N1CCN(C)CC1",
        "output": "407"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CO.COC(=O)Cc1cc(Cl)cc2nc(C)c(Cc3ccc(Cl)cc3)c(C)c12.O.[Li+].[OH-]>>Cc1nc2cc(Cl)cc(CC(=O)O)c2c(C)c1Cc1ccc(Cl)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCCC1=O.O.O=C([O-])[O-].O=Cc1ccc(F)c(F)c1.Oc1cccc(C(F)(F)F)c1.[K+].[K+]>>O=Cc1ccc(Oc2cccc(C(F)(F)F)c2)c(F)c1",
        "output": "564"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOCc1nc2cnc3ccccc3c2n1CCCC1(O[Si](C)(C)C(C)(C)C)CCCCC1.CO.Cl>>CCOCc1nc2cnc3ccccc3c2n1CCCC1(O)CCCCC1",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)c(F)c21.O=C(CBr)c1ccc(F)cc1>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCN(CC(=O)c4ccc(F)cc4)CC3)c(F)c21",
        "output": "413"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CC(=O)Cl.CCN(C(C)C)C(C)C.CN(C)C=O.ClCCl.Nc1ccn(CCCCn2cc(C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)c(=O)c1.[Na+].[OH-]>>CC(C)CC(=O)Nc1ccn(CCCCn2cc(C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)c(=O)c1",
        "output": "9"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.Nc1ccccc1.O=Cc1cc(Br)ccc1O.[Cl-].[NH4+].[Na+]>>Oc1ccc(Br)cc1CNc1ccccc1",
        "output": "359"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1ccc([N+](=O)[O-])cc1OC.CO.[Pd]>>CCOC(=O)c1ccc(N)cc1OC",
        "output": "772"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CN(C)C=O.Cc1c(-c2ccccc2)nc2ccccc2c1C(=O)O.ClCCl.NNc1ccccc1.O.O.O=C(Cl)C(=O)Cl.[Cl-].[Na+]>>Cc1c(-c2ccccc2)nc2ccccc2c1C(=O)NNc1ccccc1",
        "output": "55"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccc(Oc2cccc(OCC(=O)O)c2)cc1.NCCCN1CCCC1=O>>Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccc(Oc2cccc(OCC(=O)NCCCN3CCCC3=O)c2)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.Cl.Cn1ncc2c1CCCC2C(=O)[O-].O.[Li+].[OH-]>>Cn1ncc2c1CCCC2C(=O)O",
        "output": "151"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Nc1ccc(S(N)(=O)=O)cc1.O=C(O)c1cc(NC2CCCCC2)ncn1>>NS(=O)(=O)c1ccc(NC(=O)c2cc(NC3CCCCC3)ncn2)cc1",
        "output": "548"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C=Cc1cc(C(=O)N[C@]2(c3ccc(OC(F)(F)F)c(F)c3)CCOc3cccnc32)ccc1C(=O)OC.CO.[Na+].[OH-]>>C=Cc1cc(C(=O)N[C@]2(c3ccc(OC(F)(F)F)c(F)c3)CCOc3cccnc32)ccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)c1cccc(CN2C(=O)O[C@@H]3[C@@H]2CS(=O)(=O)C[C@H]3Cc2ccc(O)cc2)c1.Cc1cccc(C)n1.Cl.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)c1cccc(CN2C(=O)O[C@@H]3[C@@H]2CS(=O)(=O)C[C@H]3Cc2ccc(OS(=O)(=O)C(F)(F)F)cc2)c1",
        "output": "731"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCOC(C)=O.CN(C)c1ccc(P(C(C)(C)C)C(C)(C)C)cc1.CN(C)c1ccc(P(C(C)(C)C)C(C)(C)C)cc1.Cc1cc(F)ncc1B(O)O.Cl[Pd]Cl.Nc1cc2ccc(Br)cc2cn1.O.O=C([O-])[O-].[K+].[K+]>>Cc1cc(F)ncc1-c1ccc2cc(N)ncc2c1",
        "output": "899"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCCBr.Oc1ccccc1Cl>>ClCCCOc1ccccc1Cl",
        "output": "75"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1C(=O)NCCN1Cc1nnnn1-c1cccc(C(F)(F)F)c1.CI.CN(C)C=O.[H-].[Na+]>>CC1C(=O)N(C)CCN1Cc1nnnn1-c1cccc(C(F)(F)F)c1",
        "output": "83"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Oc1ccc2c(c1)C(=O)c1ccc(C#N)cc1CO2.CO.[Na+].[OH-]>>N#Cc1ccc2c(c1)COc1ccc(O)cc1C2=O",
        "output": "22"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(C(C)C)C(C)C.CCOC(C)=O.Cl.NC1CCOCC1.Nc1c(Br)cccc1C(=O)O>>Nc1c(Br)cccc1C(=O)NC1CCOCC1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCn2nc(C(F)(F)F)nc2C1COCc1ccccc1.CCO.[H][H].[Pd]>>CC(C)(C)OC(=O)N1CCn2nc(C(F)(F)F)nc2C1CO",
        "output": "178"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)CCn1ccc(-c2ncccc2CO[Si](C)(C)C(C)(C)C)n1.Cl>>COC(=O)CCn1ccc(-c2ncccc2CO)n1",
        "output": "708"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN.N#Cc1nc(Cl)c(-c2cccc(Br)c2)nc1C#N>>CCNc1nc(C#N)c(C#N)nc1-c1cccc(Br)c1",
        "output": "148"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Cl.N#Cc1cccc(F)c1.O=C([O-])[O-].Oc1ccccc1Cl.[Cs+].[Cs+]>>N#Cc1cccc(Oc2ccccc2Cl)c1",
        "output": "564"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COCOc1cc(OC)c(C(C)=O)c(OCOC)c1CC=C(C)C.O=Cc1ccc(F)cc1.[Na+].[OH-]>>COCOc1cc(OC)c(C(=O)/C=C/c2ccc(F)cc2)c(OCOC)c1CC=C(C)C",
        "output": "656"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1cc(C(=O)O)ccc1I.O=S(=O)(O)O>>COC(=O)c1ccc(I)c(C)c1",
        "output": "33"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(Cc1ccc(-n2ccnc2)cc1)N1CCOc2ccc(-n3ccnc3)cc2OCC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>c1cn(-c2ccc(CCN3CCOc4ccc(-n5ccnc5)cc4OCC3)cc2)cn1",
        "output": "112"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)CCc1ccc(OCCc2ccccc2)cc1.Cl.[Na+].[OH-]>>O=C(O)CCc1ccc(OCCc2ccccc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1nc(Sc2ccc(NC(=O)C3CC3)cc2)nc(Nc2cc(C)[nH]n2)c1N.Cl.[Li+].[OH-]>>Cc1cc(Nc2nc(Sc3ccc(NC(=O)C4CC4)cc3)nc(C(=O)O)c2N)n[nH]1",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCCc1ccc(OCc2ccccc2)cc1.CCN(C(C)C)C(C)C.CN(C)C=O.c1cnc2c(N3CCNCC3)cccc2c1>>c1ccc(COc2ccc(CCN3CCN(c4cccc5cccnc45)CC3)cc2)cc1",
        "output": "73"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(O)C(O)c1ccccc1.OCCCl>>O=C(OCCCl)C(O)c1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.COc1cc(C=O)cc(I)c1O.O.O=S(=O)(O)O>>COc1cc(C=O)cc(I)c1OC(C)=O",
        "output": "46"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.Cc1ccc(Cl)c(O)c1.O=C(O)CC(O)(CC(=O)O)C(=O)O.[H-].[Na+]>>COc1cc(C)ccc1Cl",
        "output": "62"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C=Cc1ccc2c(c1)c(CCC(=O)OC)c(-c1ccc(Cl)cc1)n2C.CCN(CC)CC.CCN=C=NCCCN(C)C.CO.Cl.O.O.O.OC1(Cc2ccccc2)CCNCC1.On1nnc2ccccc21.[Li+].[OH-]>>C=Cc1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C",
        "output": "227"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccc(Nc2ccccn2)cc1>>Nc1ccc(Nc2ccccn2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cl[Pd]Cl.FC1(F)CCC(Oc2ccc(Br)cc2)CC1.O.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc(OC3CCC(F)(F)CC3)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1cccc(C(=O)O)n1.On1nnc2ccccc21>>Cc1cccc(C(=O)N2CCOCC2)n1",
        "output": "605"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCCCC.Cc1noc(NC(=O)OCC(Cl)(Cl)Cl)c1C.Cl.Cl.Fc1ccc(F)c(-c2ccnc(N3CCNCC3)n2)c1>>Cc1noc(NC(=O)N2CCN(c3nccc(-c4cc(F)ccc4F)n3)CC2)c1C",
        "output": "980"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CCCCN.CO.COc1ccc(Sc2ccc(C=O)cc2)cc1.C[N+](=O)[O-]>>COc1ccc(Sc2ccc(C=C[N+](=O)[O-])cc2)cc1",
        "output": "282"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCOC(C)=O.COc1cncnc1N1CCNCC1.O=[N+]([O-])c1ccc2[nH]cc(CCCBr)c2c1>>COc1cncnc1N1CCN(CCCc2c[nH]c3ccc([N+](=O)[O-])cc23)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(C)=O.NC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)CCCC(N)C(=O)O)[C@H]2SC1.O=C(Cl)CCl.O=S(=O)(O)O.[Na+].[Na+].[Na+].[Na+].[O-]B([O-])[O-].[OH-]>>NC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)CCCC(NC(=O)CCl)C(=O)O)[C@H]2SC1",
        "output": "585"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOCC.CC[SiH](CC)CC.COC(=O)NC1CCc2c(ccc(OC)c2OC)C1=O.FB(F)F.O=C([O-])O.[Na+]>>COC(=O)NC1CCc2c(ccc(OC)c2OC)C1",
        "output": "92"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C(O)c1cccc(CO)c1.O=C([O-])O.O=S(=O)(O)O.[Na+]>>COC(=O)c1cccc(CO)c1",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1CCCC1=O.ClCCl.Nc1cc(F)c(F)c(CO)c1.O=C([O-])O.O=S(Cl)Cl.[Na+]>>Nc1cc(F)c(F)c(CCl)c1",
        "output": "81"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCC2(CC1)CCNCC2.C1CCOC1.CC(=O)OC(C)=O>>CC(=O)N1CCC2(CCCCC2)CC1",
        "output": "369"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(=O)O.CCc1ccc(C2CC(N)CN(C(=O)C3CCCC3)C2)cc1.O=C(O)C(F)(F)F>>CCc1ccc(C2CC(NC(=O)C(C)(C)C)CN(C(=O)C3CCCC3)C2)cc1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)O.COc1ccc(C2=NN(C3CCNCC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>COc1ccc(C2=NN(C3CCN(C(=O)[C@@H](CN(C)C)NC(=O)OC(C)(C)C)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.COC(=O)CBr.COc1ccc(CCC(=O)c2c(OC)cc(OC)c(CC=C(C)C)c2O)cc1.[H-].[Na+]>>COC(=O)COc1c(CC=C(C)C)c(OC)cc(OC)c1C(=O)CCc1ccc(OC)cc1",
        "output": "557"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)OB(c2cnc(N)nc2)OC1(C)C.Cc1c(-c2cccc(S(=O)(=O)C[C@H](C)O)c2)sc2c(N3CCOCC3)nc(Cl)nc12>>Cc1c(-c2cccc(S(=O)(=O)C[C@H](C)O)c2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12",
        "output": "973"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.CC(=O)O.CC(C)c1cccc2c1NC(=O)C2=O>>CC(C)c1cc(Br)cc2c1NC(=O)C2=O",
        "output": "98"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "NC1CC1.O=C(Nc1ccc(CNc2nc(Cl)nc3ccccc23)cc1)c1ccc(F)cc1>>O=C(Nc1ccc(CNc2nc(NC3CC3)nc3ccccc23)cc1)c1ccc(F)cc1",
        "output": "544"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CI.OC1(c2ccccc2)CCCCCC1.[H-].[Na+]>>COC1(c2ccccc2)CCCCCC1",
        "output": "140"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCc1ccc(C2CC(C(=O)O)CN(C(=O)N3CCOCC3)C2)cc1.NC(=NO)c1cccc(Cl)c1>>CCc1ccc(C2CC(c3nc(-c4cccc(Cl)c4)no3)CN(C(=O)N3CCOCC3)C2)cc1",
        "output": "926"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1=COCCC1.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.OCCc1ccc(Br)cc1>>Brc1ccc(CCOC2CCCCO2)cc1",
        "output": "141"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cccc(S(N)(=O)=O)c1.O=C(O)c1ccccc1C1CCCCC1>>NS(=O)(=O)c1cccc(NC(=O)c2ccccc2C2CCCCC2)c1",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)C(=O)OC[C@H]1O[C@@H](Oc2nn(CCCO)c3nccc(CCc4ccc(OC(=O)C(C)(C)C)cc4)c23)[C@H](OC(=O)C(C)(C)C)[C@@H](OC(=O)C(C)(C)C)[C@@H]1OC(=O)C(C)(C)C.CCN(CC)CC.CS(=O)(=O)Cl.Cl.ClCCl>>CC(C)(C)C(=O)OC[C@H]1O[C@@H](Oc2nn(CCCOS(C)(=O)=O)c3nccc(CCc4ccc(OC(=O)C(C)(C)C)cc4)c23)[C@H](OC(=O)C(C)(C)C)[C@@H](OC(=O)C(C)(C)C)[C@@H]1OC(=O)C(C)(C)C",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)CC1Cc2ccc(CCCc3nc4ccccc4[nH]3)cc2Cc2ccccc21.[Na+].[OH-]>>O=C(O)CC1Cc2ccc(CCCc3nc4ccccc4[nH]3)cc2Cc2ccccc21",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1cc(C(C)(C)NC(=O)OCc2ccccc2)ns1.CSc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1cc(C(C)(C)N)ns1",
        "output": "574"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COc1ccccc1N.O=[N+]([O-])c1ccccc1F.[H-].[Na+]>>COc1ccccc1Nc1ccccc1[N+](=O)[O-]",
        "output": "609"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CCO.Cl.NO.O=C1c2ccccc2CCC1Cc1ccccc1.[Na+]>>ON=C1c2ccccc2CCC1Cc1ccccc1",
        "output": "212"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCC(c2ccc(N)nc2)C1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1CCC(c2cnc(N)c(Br)c2)C1",
        "output": "518"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCC1CN(Cc2ccccc2)CCO1>>CC(C)(C)OC(=O)NCC1CN(Cc2ccccc2)CCO1",
        "output": "631"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)C1CCC(CC(=O)OC(C)(C)C)CC1.CO.Cl.O.[K+].[OH-]>>CC(C)(C)OC(=O)CC1CCC(C(=O)O)CC1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.Clc1cccc(Cl)c1CBr.Nc1nc2ccc(O)cc2s1.O=C([O-])O.[Na+].[Na+].[OH-]>>Nc1nc2ccc(OCc3c(Cl)cccc3Cl)cc2s1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(CO)CC1.Fc1ccc(CBr)cc1.O.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCC(COCc2ccc(F)cc2)CC1",
        "output": "464"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCNCC2)c1.O=C(CCCCCl)c1ccccc1F.O=C([O-])[O-].[K+].[K+]>>CC(C)C(=O)Nc1cccc(C2CCN(CCCCC(=O)c3ccccc3F)CC2)c1",
        "output": "138"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCO.CC(C)NC(C)C.Fc1ccc(I)cc1.[Cu]I>>OCC#Cc1ccc(F)cc1",
        "output": "664"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.C[C@H]1CNCCN1C(=O)C1CCCC1.ClCCl.O=Cc1cccc([N+](=O)[O-])c1Cl.[Na+]>>C[C@H]1CN(Cc2cccc([N+](=O)[O-])c2Cl)CCN1C(=O)C1CCCC1",
        "output": "567"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.Nc1cc(Br)ccc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>CC(=O)Nc1cc(Br)ccc1[N+](=O)[O-]",
        "output": "9"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNC1.CC(C)O.CN(C)c1ccccc1.NC1=NNC(N)(N2CCCC2)C=C1.Nc1ccc(Cl)nn1.[Cu]>>Nc1ccc(N2CCCC2)nn1",
        "output": "406"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1nc(C)c(-c2cc(CCl)on2)s1.Fc1cccc(-c2nc3cn[nH]cc-3n2)c1F>>Cc1nc(C)c(-c2cc(Cn3cc4nc(-c5cccc(F)c5F)nc-4cn3)on2)s1",
        "output": "997"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "N[C@@H]1CCCC[C@@H]1N.O=C1c2ccccc2COc2cc(F)ccc21>>N[C@H]1CCCC[C@H]1Nc1ccc2c(c1)OCc1ccccc1C2=O",
        "output": "572"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1NCC2COCC1N2.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCn1c(C=O)nc2c(N3CCOCC3)nc(Cl)nc21.ClCCCl.O.[Na+]>>CCn1c(CN2CC3COCC(C2)N3)nc2c(N3CCOCC3)nc(Cl)nc21",
        "output": "944"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COCC(=N)NO.O=C(O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)N2CCOCC2)C1>>COCc1noc(C2CC(c3ccc(OC(F)(F)F)cc3)CN(C(=O)N3CCOCC3)C2)n1",
        "output": "924"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCNCC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)Cc1noc2cc(Br)ccc12.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCN(C(=O)Cc2noc3cc(Br)ccc23)CC1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O.CCOC(=O)[C@H](O)[C@@H](Cc1ccccc1)NC(=O)CCCc1ccccc1C(=O)O.[Na+].[OH-]>>O=C(CCCc1ccccc1C(=O)O)N[C@H](Cc1ccccc1)[C@@H](O)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)CCCNC1.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[B-](F)(F)F.O=C(O)c1cc(Nc2ccc3c(c2)CC2(C3)C(=O)Nc3ncccc32)ncn1>>CC1(C)CCCN(C(=O)c2cc(Nc3ccc4c(c3)CC3(C4)C(=O)Nc4ncccc43)ncn2)C1",
        "output": "605"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)CCc1cn(C)c2cc(-c3ccccc3Cl)c3c(c12)C(=O)NC3=O.CCO.[BH4-].[Cl-].[Cl-].[Na+].[Zn+2]>>CC(O)CCc1cn(C)c2cc(-c3ccccc3Cl)c3c(c12)C(=O)NC3=O",
        "output": "91"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C(=O)O)CC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.O=c1[nH]c2c(c3ccccc13)COC(C1CC[NH2+]CC1)C2>>CC1(C(=O)N2CCC(C3Cc4[nH]c(=O)c5ccccc5c4CO3)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.C[O-].Cc1ccc(S(=O)(=O)n2cc(-c3ncc(F)c(N[C@H](CC(=O)O)C(C)(C)C)n3)c3cc(Cl)cnc32)cc1.[Na+]>>CC(C)(C)[C@@H](CC(=O)O)Nc1nc(-c2c[nH]c3ncc(Cl)cc23)ncc1F",
        "output": "949"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCc1noc([C@@H]2CCCN2C(=O)OC(C)(C)C)n1.CCOCC.ClCCl.O=C(O)C(F)(F)F.[Na+].[OH-]>>CCCCCCCCc1noc([C@@H]2CCCN2)n1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(-c2cnc(Nc3cnc(C)c(NC(=O)C4CCCCN4C(=O)OC(C)(C)C)c3)nc2)cc1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(-c2cnc(Nc3cnc(C)c(NC(=O)C4CCCCN4)c3)nc2)cc1",
        "output": "634"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CC(Oc2ccc(F)cc2F)CC1C(=O)O.CSC>>CC(C)(C)OC(=O)N1CC(Oc2ccc(F)cc2F)CC1CO",
        "output": "218"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)O.CC(C)(C)[O-].CN.COc1ccc(OC)c(P(C2CCCCC2)C2CCCCC2)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.Cl[Pd+].Clc1ccc2ncccc2c1.NCCc1[c-]cccc1.[Na+]>>CNc1ccc2ncccc2c1",
        "output": "304"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(=O)C1CCNCC1.CCOC(C)=O.O=C(Cl)OCc1ccccc1.O=C([O-])O.[Na+]>>CCOC(=O)C1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "427"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Cl.NN(c1ccccc1)c1ccccc1.O.O=Cc1ccccc1>>C(=NN(c1ccccc1)c1ccccc1)c1ccccc1",
        "output": "167"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cc2n(n1)CCCN(C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2.CO.Cl.O.[Cl-].[Na+].[Na+].[OH-]>>O=C(O)c1cc2n(n1)CCCN(C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.ClCCl.O=[Mn]=O.OCc1ccc2ncnc(N3CCCCC3)c2n1.[Mn+2].[O-2]>>O=Cc1ccc2ncnc(N3CCCCC3)c2n1",
        "output": "263"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=C[C@@H]1C[C@]1(N)C(=O)NS(=O)(=O)c1ccccc1NC(=O)CCCCCCCC(=O)OC.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COc1ccc2c(O[C@@H]3C[C@@H](C(=O)O)N(C(=O)OC(C)(C)C)C3)cc(-c3ccccc3)nc2c1.ClCCl.F[P-](F)(F)(F)(F)F>>C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2cc(-c3ccccc3)nc3cc(OC)ccc23)CN1C(=O)OC(C)(C)C)C(=O)NS(=O)(=O)c1ccccc1NC(=O)CCCCCCCC(=O)OC",
        "output": "131"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC(O)c1cc(I)ccc1Oc1ccnc2cc(OC)c(OC)cc12.CS(C)=O.O>>CCC(=O)c1cc(I)ccc1Oc1ccnc2cc(OC)c(OC)cc12",
        "output": "32"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)c(C)c1.Cl.ClCCl.O=C1NCCC12CCCNC2>>Cc1ccc(S(=O)(=O)N2CCCC3(CCNC3=O)C2)c(C)c1",
        "output": "99"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N1Cc2nc(Cl)nc(N3CCOCC3)c2C1.CCNC(=O)Nc1ccc(B2OC(C)(C)C(C)(C)O2)c(F)c1>>CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CN(C(C)=O)C3)c(F)c1",
        "output": "974"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)Cc1ccc(Nc2nc3ccc(F)cc3s2)c(Cl)c1.[Na+].[OH-]>>O=C(O)Cc1ccc(Nc2nc3ccc(F)cc3s2)c(Cl)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc(C(=O)Nc2nc3ccc(OC)cc3s2)cc1.O.[Li+].[OH-]>>COc1ccc2nc(NC(=O)c3ccc(C(=O)O)cc3)sc2c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)CC1.CN(C)C=O.N#Cc1ccc(F)cc1.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(C#N)cc2)CC1",
        "output": "485"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Cc1cccc(C(=O)O)c1Br.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1cccc(CO)c1Br",
        "output": "72"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCN(C(=O)c2cccc(Nc3c(Cl)c(=O)c3=O)c2O)CC1.CS(C)=O.Nc1ccc(F)cc1F>>CN1CCN(C(=O)c2cccc(Nc3c(Nc4ccc(F)cc4F)c(=O)c3=O)c2O)CC1",
        "output": "510"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C)CCOc1cccc(C#N)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CN(C)CCOc1cccc(CN)c1",
        "output": "175"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(C#Cc2ccccc2)cc1[N+](=O)[O-].Cl[Sn]Cl.O.O>>CC(C)(C)OC(=O)Nc1ccc(C#Cc2ccccc2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C[C@@H]1CC[C@@H](Oc2cc(OC(F)F)ccn2)CN1C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>C[C@@H]1CC[C@@H](Oc2cc(OC(F)F)ccn2)CN1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CNCCN1.COc1cc(F)ccc1-c1nnc(-c2c(-c3ccccc3)noc2C)o1>>COc1cc(N2CCNCC2)ccc1-c1nnc(-c2c(-c3ccccc3)noc2C)o1",
        "output": "26"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC1CC(N=[N+]=[N-])CCN(c2c([N+](=O)[O-])cnn2C)C1.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC1CC(N)CCN(c2c([N+](=O)[O-])cnn2C)C1",
        "output": "89"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "NCCC1CCC(CN2CCCC2)CC1.O=C(O)c1ccc(-c2ccc(Cl)cc2)cc1>>O=C(NCCC1CCC(CN2CCCC2)CC1)c1ccc(-c2ccc(Cl)cc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)Nc1cc(F)cc(CCCCC(=O)OC)c1F.CO.C[O-].Cl.O.[Li+]>>CCOC(=O)Nc1cc(F)cc(CCCCC(=O)O)c1F",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1cnc2ccc(OC(SC)C(=O)NC3(C=O)CCC3)cc2c1.CC(=O)[O-].CCO.CON.Cl.O.[Na+]>>C#Cc1cnc2ccc(OC(SC)C(=O)NC3(C=NOC)CCC3)cc2c1",
        "output": "118"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1ccnc(Cl)n1.CCO.CN>>CNc1nccc(C(C)(C)C)n1",
        "output": "544"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.O=[N+]([O-])c1ccccc1Nc1c(F)cccc1F.[Ni]>>Nc1ccccc1Nc1c(F)cccc1F",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCC(NC1CCc2cc(F)cc(F)c2C1)C(=O)O.CN(C)CC(C)(C)n1cnc(N)c1>>CCCC(NC1CCc2cc(F)cc(F)c2C1)C(=O)Nc1cn(C(C)(C)CN(C)C)cn1",
        "output": "692"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCOC(=O)N(CC(Cc1cccnc1)c1ccc(OCOC)cc1)S(=O)(=O)c1ccc(Cl)cc1.Cl.ClCCl.O.O=C([O-])O.[Na+]>>CCOC(=O)N(CC(Cc1cccnc1)c1ccc(O)cc1)S(=O)(=O)c1ccc(Cl)cc1",
        "output": "755"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCOC(=O)c1cnc2c(C(F)(F)F)cccc2c1O.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)c1cnc2c(C(F)(F)F)cccc2c1OS(=O)(=O)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CNCCNC.COc1cc(Br)cc(OC)c1.ClCCl.I[Cu]I.O=P([O-])([O-])[O-].[K+].[K+].[K+].c1ccc2c(c1)[nH]c1ccccc12>>COc1cc(OC)cc(-n2c3ccccc3c3ccccc32)c1",
        "output": "349"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC2=NCCCN2CC1.CC#N.CC(C)(C)[Si](C)(C)Cl.N[C@@H](CCO)C(=O)O>>CC(C)(C)[Si](C)(C)OCC[C@H](N)C(=O)O",
        "output": "193"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.N#Cc1ccc(CN)cc1Br.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)OC(=O)NCc1ccc(C#N)c(Br)c1",
        "output": "686"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)Nc1cc(Oc2cc(F)c(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)cc2F)ccn1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>Nc1cc(Oc2cc(F)c(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)cc2F)ccn1",
        "output": "885"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCc1ccc(S(=O)(=O)c2ccc(F)cc2)cc1S(=O)(=O)Cl.NCCC1CCOCC1>>CCCc1ccc(S(=O)(=O)c2ccc(F)cc2)cc1S(=O)(=O)NCCC1CCOCC1",
        "output": "43"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCCS(=O)(=O)Nc1ccc(F)c(C(O)c2c[nH]c3ncc(C(F)(F)F)cc23)c1F.ClCCl>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(C(F)(F)F)cc23)c1F",
        "output": "852"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.Nc1nccs1.O=C1C(=O)N(C(CC2CCCC2)C(=O)O)c2cc(Cl)ccc21>>O=C1C(=O)N(C(CC2CCCC2)C(=O)Nc2nccs2)c2cc(Cl)ccc21",
        "output": "681"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cc1cc(Cl)c(Cl)cc1[N+](=O)[O-].O=C([O-])[O-].Oc1ccc(Cl)c2c1CCCC2.[K+].[K+]>>Cc1cc(Oc2ccc(Cl)c3c2CCCC3)c(Cl)cc1[N+](=O)[O-]",
        "output": "299"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(CC(C)(C)N)cc1.c1ccc(CCCCCCOCC2CO2)cc1>>COc1ccc(CC(C)(C)NCC(O)COCCCCCCc2ccccc2)cc1",
        "output": "16"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(=O)(=O)Cl.ClCCl.Nc1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1.c1ccncc1>>CS(=O)(=O)Nc1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cc1",
        "output": "194"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nc1cccc(Cl)c1.O=c1[nH]c2c(F)cccc2c(CBr)c1F>>O=c1[nH]c2c(F)cccc2c(CNc2cccc(Cl)c2)c1F",
        "output": "272"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCCN1CCC(Cc2ccccc2)CC1.ClC(Cl)Cl.O=C(O)C(F)(F)F>>NCCN1CCC(Cc2ccccc2)CC1",
        "output": "538"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.O=C1CCc2ccc([N+](=O)[O-])cc21.[H][H].[Pd]>>Nc1ccc2c(c1)C(=O)CC2",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1cnc(Cl)cc1C1(O)CCOCC1.ClCCl.O=C(O)C(F)(F)F>>Nc1cnc(Cl)cc1C1(O)CCOCC1",
        "output": "877"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C(Br)CC.CN(C)C=O.O.O=C([O-])[O-].Oc1ccc2ncc(Br)cc2c1.[Cl-].[K+].[K+].[Na+]>>CCOC(=O)C(CC)Oc1ccc2ncc(Br)cc2c1",
        "output": "455"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCCCOc1ccccc1.N#CC1CCCCN1>>N#CC1CCCCN1CCCOc1ccccc1",
        "output": "73"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)n1nccc1C1=C(CCl)CN(C)C1.CN(C)C=O.O.O=C([O-])[O-].O=Cc1c(O)cccc1O.[K+].[K+]>>CC(C)n1nccc1C1=C(COc2cccc(O)c2C=O)CN(C)C1",
        "output": "119"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CN1CCCC1=O.CN1CCNCC1.O.O=C([O-])[O-].O=Cc1cn(CCCl)c2cccc(Br)c12.[I-].[I-].[K+].[K+].[Na+]>>CN1CCN(CCn2cc(C=O)c3c(Br)cccc32)CC1",
        "output": "138"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)Cc1cc2ccc(F)cc2c(-c2ccc(S(=O)(=O)c3ccc(F)cc3F)cc2)c1C.O.O.[Li+].[OH-]>>Cc1c(CC(=O)O)cc2ccc(F)cc2c1-c1ccc(S(=O)(=O)c2ccc(F)cc2F)cc1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.Nc1cccc2ccc(O)cc12.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>O=C(Nc1cccc2ccc(O)cc12)C(F)(F)F",
        "output": "106"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1c([N+](=O)[O-])cccc1S(=O)(=O)NC(C)(C)C.O=C(O)C(F)(F)F>>COC(=O)c1c([N+](=O)[O-])cccc1S(N)(=O)=O",
        "output": "680"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc2nc(-c3cc4cc(C(F)(F)F)ccc4o3)c(N3CCC[C@@H]3C)nc2c1.O.[Na+].[OH-]>>C[C@H]1CCCN1c1nc2cc(C(=O)O)ccc2nc1-c1cc2cc(C(F)(F)F)ccc2o1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1cc(Oc2ncc(C(=O)N3CCC3)cc2Cl)cc(O[C@@H](C)CO)c1.O.O.[Li+].[OH-]>>C[C@@H](CO)Oc1cc(Oc2ncc(C(=O)N3CCC3)cc2Cl)cc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)[C@@H](NC(=O)OC(C)(C)C)C(=O)O.CCN(C(C)C)C(C)C.CN(C)C=O.C[C@]1(O)CNCC[C@]1(O)c1ccc(Cl)cc1.ClCCCl.ClCCl.On1nnc2ccccc21>>CC(C)[C@@H](NC(=O)OC(C)(C)C)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)[C@@](C)(O)C1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNCC1.CN(C)C=O.COC(=O)c1cc(C)c2c(c1)S(=O)(=O)Cc1cc(NC(=O)CCl)cc(Cl)c1O2>>COC(=O)c1cc(C)c2c(c1)S(=O)(=O)Cc1cc(NC(=O)CN3CCCCC3)cc(Cl)c1O2",
        "output": "340"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.O=C(O)c1cc(F)c(F)c(F)c1F.O=S(Cl)Cl>>O=C(Cl)c1cc(F)c(F)c(F)c1F",
        "output": "3"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2c(Cl)ccc(N)c2O)CC1.NC(N)=O.O=C=Nc1cccc(Cl)c1Cl>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2c(Cl)ccc(NC(=O)Nc3cccc(Cl)c3Cl)c2O)CC1",
        "output": "473"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CC(C)(C)c1nc2cc(C(=O)O)ccc2n1CC1CCC(F)(F)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc3c(c2)nc(C(C)(C)C)n3CC2CCC(F)(F)CC2)CC1",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)C1CC=C(c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C(=O)N(C)C)ccc23)CC1.O.[Li]O>>CN(C)C(=O)c1ccc2c(C3=CCC(C(=O)O)CC3)nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.ClCCl.Nc1cncc(-c2ccc(-c3ccc4c(c3)C(=O)NCC4)s2)c1.O=S(=O)(Cl)c1ccc(F)cc1F>>O=C1NCCc2ccc(-c3ccc(-c4cncc(NS(=O)(=O)c5ccc(F)cc5F)c4)s3)cc21",
        "output": "554"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.NC(CO)(CO)CO.N[C@@H]1CC[C@@H](Nc2cc(-n3c(C(F)F)nc4ccccc43)nc(N3CCOCC3)n2)CC1.O=Cc1ccccc1.O=S(=O)(Cl)CCC(F)(F)F>>O=S(=O)(CCC(F)(F)F)N[C@@H]1CC[C@@H](Nc2cc(-n3c(C(F)F)nc4ccccc43)nc(N3CCOCC3)n2)CC1",
        "output": "493"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)c1cc(C#N)c(N2CC(C(=O)O)C2)nc1C(F)F.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COc1cccc(CS(N)(=O)=O)c1.ClCCl.F[B-](F)(F)F.O=C([O-])O.[Na+]>>CCOC(=O)c1cc(C#N)c(N2CC(C(=O)NS(=O)(=O)Cc3cccc(OC)c3)C2)nc1C(F)F",
        "output": "644"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)c1ccc(F)nc1.CC1(NC(=O)OCc2ccccc2)CCNCC1>>CC1(NC(=O)OCc2ccccc2)CCN(c2ccc(C(=O)OC(C)(C)C)cn2)CC1",
        "output": "756"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNC1.O=C(O)COc1ccc2c(c1)N(c1nc(-c3ccc(Cl)s3)nc3c1CCC3)CC2>>O=C(COc1ccc2c(c1)N(c1nc(-c3ccc(Cl)s3)nc3c1CCC3)CC2)N1CCC1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(N=C2NCCN2)c(Cl)c1.O=S(=O)(O)O.O=[N+]([O-])O>>Cc1cc(Cl)c(N=C2NCCN2)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=CCC(C)(C)C(=O)O.ClCCl.O=C(Cl)C(=O)Cl>>C=CCC(C)(C)C(=O)Cl",
        "output": "56"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C(C)Oc1cccc(Oc2c(Cl)cc(C(F)(F)F)cc2Cl)c1.Cl.O.[Na+].[OH-]>>CC(Oc1cccc(Oc2c(Cl)cc(C(F)(F)F)cc2Cl)c1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1ccc(O)c(C(=O)O)c1.CCCO.CN(C)C=O.CN(C)CCCN=C=N.Cl.O.O.On1nnc2ccccc21>>CCCOC(=O)c1cc(C(C)=O)ccc1O",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.ClCCl.Clc1cncc(Cl)n1.OCCF>>FCCOc1cncc(Cl)n1",
        "output": "209"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)O.CNC.Cc1ccc2nc(Cl)nc(NCc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c2c1.Cl>>Cc1ccc2nc(N(C)C)nc(NCc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c2c1",
        "output": "36"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)C(Cc1c(C)cc(C(N)=O)cc1C)NC(=O)OC(C)(C)C.CS(C)=O.O.O=C([O-])[O-].OO.[K+].[K+]>>Cc1cc(C(N)=O)cc(C)c1CC(NC(=O)OC(C)(C)C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)NCCc4ccc(C5CC5)nc4OC)cc3)c(Cl)cc21.CCOC(C)=O.Cl.[Na+].[OH-]>>COc1nc(C2CC2)ccc1CCNC(=O)c1ccc(Oc2cc3c(cc2Cl)C(C(=O)O)CCO3)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCN(c1cc(Br)cc(C(=O)O)c1C)[C@@H]1CC[C@@H](N(C)C)CC1.COc1c(CN)c(C)nn1C.CS(C)=O.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CCN(c1cc(Br)cc(C(=O)NCc2c(C)nn(C)c2OC)c1C)[C@@H]1CC[C@@H](N(C)C)CC1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc(-n2nc(N3CCN(C(=O)OC(C)(C)C)CC3)cc2NC(=O)c2cnn3cccnc23)nc1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(-n2nc(N3CCNCC3)cc2NC(=O)c2cnn3cccnc23)nc1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Cc1ccc(C)cc1.NCC(O)c1ccccc1.c1ccccc1>>Cc1ccc(CC(C)NCC(O)c2ccccc2)cc1",
        "output": "236"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[B-](F)(F)F.N[C@H]1CCC[C@@H]1Nc1ccc(C(F)(F)F)cn1.O.O=C(O)c1cc(Cl)ccc1-n1nccn1>>O=C(N[C@H]1CCC[C@@H]1Nc1ccc(C(F)(F)F)cn1)c1cc(Cl)ccc1-n1nccn1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCNCC2)c1.O=C(CCCCl)c1cccs1.O=C([O-])[O-].[K+].[K+]>>CC(C)C(=O)Nc1cccc(C2CCN(CCCC(=O)c3cccs3)CC2)c1",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.O=[N+]([O-])c1ccc(-c2coc(-c3ccccc3)n2)cc1.[Zn]>>Nc1ccc(-c2coc(-c3ccccc3)n2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C/C(=C\\c1ccc(C)cc1)CCCO.CCOCC.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>C/C(=C\\c1ccc(C)cc1)CCC=O",
        "output": "142"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOc1cc(-c2cc(C(F)F)n3ncc(C(=O)O)c3n2)ccc1C(F)(F)F.CS(=O)(=O)c1cccc(N)c1.Cl>>CCOc1cc(-c2cc(C(F)F)n3ncc(C(=O)Nc4cccc(S(C)(=O)=O)c4)c3n2)ccc1C(F)(F)F",
        "output": "969"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.NCCNCCN.O=Cc1ccccc1.[BH4-].[Na+]>>NCCNCCNCc1ccccc1",
        "output": "468"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1ccc(CCn2ccc(OCc3ccc(F)cc3)cc2=O)cc1OC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1cc(CCn2ccc(OCc3ccc(F)cc3)cc2=O)ccc1CO",
        "output": "444"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)N1CC(=O)N(C)c2cnc(Cl)nc21.Cl.Nc1cc(C(=O)O)cc(C(F)(F)F)c1.O>>CC(C)N1CC(=O)N(C)c2cnc(Nc3cc(C(=O)O)cc(C(F)(F)F)c3)nc21",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CN1CCC(CCCCO)CC1.N#Cc1cccc(O)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN1CCC(CCCCOc2cccc(C#N)c2)CC1",
        "output": "478"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O=[N+]([O-])c1cc(C2CC2)ccc1Nc1cccc(-c2ccon2)c1.[Pd]>>Nc1cc(C2CC2)ccc1Nc1cccc(-c2ccon2)c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CC(=O)Nc1cccc(N)c1.CCOC(C)=O.CN(C)C=O.COc1cnc(Cl)nc1Cl.O=C([O-])[O-].[K+].[K+]>>C=CC(=O)Nc1cccc(Nc2nc(Cl)ncc2OC)c1",
        "output": "352"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(C)=O.O=C(Cl)C(=O)Cl.OCCOc1cccc(-c2ccsc2)c1>>O=CCOc1cccc(-c2ccsc2)c1",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)(C)N.CO.NS(=O)(=O)c1nc2ccc(OCC3CO3)cc2s1>>CC(C)(C)NCC(O)COc1ccc2nc(S(N)(=O)=O)sc2c1",
        "output": "16"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)C1Cc2c(ncn2Cc2ccc([N+](=O)[O-])c(C)c2)CN1C(=O)C(c1ccccc1)c1ccccc1.OCC1CCCO1.[Ni]>>COC(=O)C1Cc2c(ncn2Cc2ccc(N)c(C)c2)CN1C(=O)C(c1ccccc1)c1ccccc1",
        "output": "507"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CI.CN(C)C=O.CO.N#CCc1nc2ccccc2[nH]1.O.O=C([O-])[O-].[K+].[K+]>>Cn1c(CC#N)nc2ccccc21",
        "output": "404"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.O.[N-]=[N+]=NCC(F)Cn1c2ccc(Br)cc2c2cc(Br)ccc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NCC(F)Cn1c2ccc(Br)cc2c2cc(Br)ccc21",
        "output": "89"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)NCCCCc1ccccc1.CC(Cl)C(=O)Cl.CC(Cl)Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)NCCCCc1ccc(C(=O)C(C)Cl)cc1",
        "output": "31"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COC1(c2nccn2C)CCN(C(=O)OC(C)(C)C)CC1>>COC1(c2nccn2C)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C[C@@H]1NC[C@H](CC2CC2)NC1=O.CC(C)C[C@H]1CN(C(=O)/C=C/c2ccccc2)[C@@H](CC(C)C)C(=O)N1.O=C(O)[C@@H]1C[C@H]1c1ccc(Cl)cc1>>CC(C)C[C@H]1C(=O)N[C@@H](CC2CC2)CN1C(=O)[C@@H]1C[C@H]1c1ccc(Cl)cc1",
        "output": "297"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.Nc1c2c(nc3ccc([N+](=O)[O-])cc13)CCCC2=O.[Na+].[OH-].[Pd]>>Nc1ccc2nc3c(c(N)c2c1)C(=O)CCC3",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)C(=NOCC(C)C)c1csc(N)n1.CO.[Na+].[OH-]>>CC(C)CON=C(C(=O)O)c1csc(N)n1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)[O-].CCOC(C)=O.O.O=[N+]([O-])c1ccc(F)cc1.OCCn1cccn1.[K+]>>O=[N+]([O-])c1ccc(OCCn2cccn2)cc1",
        "output": "485"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[C@H](NC(=O)CC1CCCCC1)C(=O)N1C[C@]2(C[C@H]1C(=O)O)CN(c1ccccc1)C(=O)O2.CCC[C@H](N)C(O)C(=O)NC1CC1>>CCC[C@H](NC(=O)[C@@H]1C[C@]2(CN(c3ccccc3)C(=O)O2)CN1C(=O)[C@@H](NC(=O)CC1CCCCC1)C(C)(C)C)C(O)C(=O)NC1CC1",
        "output": "216"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br.COc1ccc2nc(C(=O)O)ccc2c1.Cl.O.[NH4+].[OH-]>>O=C(O)c1ccc2cc(O)ccc2n1",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)C(CO)c1ccc(Nc2ncc(-c3ccc(OC(F)F)cc3)cn2)cc1.CO.O.O.[Li+].[OH-]>>O=C(O)C(CO)c1ccc(Nc2ncc(-c3ccc(OC(F)F)cc3)cn2)cc1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nc1ccc(Cl)c(C(=O)O)c1.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[Li+].[NH4+]>>Nc1ccc(Cl)c(CO)c1",
        "output": "72"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(NS(=O)(=O)c2ccc(C(=O)O)c3ccccc23)CC1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl.NC1CCCCC1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCC(NS(=O)(=O)c2ccc(C(=O)NC3CCCCC3)c3ccccc23)CC1",
        "output": "835"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1.O=C1CCC(Oc2ncc(Br)cn2)CC1>>O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(Oc3ncc(Br)cn3)CC2)C1",
        "output": "187"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COCCOC.COc1cc(-c2nc3ccccc3o2)ccc1-c1cccc(Br)n1.COc1cc(-c2nc3ccccc3o2)ccc1B1OC(C)(C)C(C)(C)O1.Clc1ccc(Br)cn1.O.O=C([O-])[O-].[Na+].[Na+]>>COc1cc(-c2nc3ccccc3o2)ccc1-c1ccc(Cl)nc1",
        "output": "938"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCl.Nc1cc(Br)cc(C(F)(F)F)c1.O=C=Nc1ccc(Cl)c(C(F)(F)F)c1>>O=C(Nc1cc(Br)cc(C(F)(F)F)c1)Nc1ccc(Cl)c(C(F)(F)F)c1",
        "output": "473"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)OC1CCCC(N)CCC1.CCN(C(C)C)C(C)C.ClCCl.O=C(Cl)OCc1ccccc1>>CC(C)(C)[Si](C)(C)OC1CCCC(NC(=O)OCc2ccccc2)CCC1",
        "output": "479"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN.COc1ccc2c(c1)C(=O)N1CCC[C@H]1c1c(C(=O)O)ncn1-2.ClCCl.O=S(Cl)Cl>>CNC(=O)c1ncn2c1[C@@H]1CCCN1C(=O)c1cc(OC)ccc1-2",
        "output": "697"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOc1cc(/C=C/C(=O)OC)ccc1-c1ccc(OC)cc1.CO.O.[K+].[OH-]>>CCOc1cc(/C=C/C(=O)O)ccc1-c1ccc(OC)cc1",
        "output": "58"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCNc1ccc(N)cc1-c1nc2ccc(F)cc2o1.O=C(O)c1ccc2c(c1)C(=O)OC2=O>>CCCNc1ccc(N2C(=O)c3ccc(C(=O)O)cc3C2=O)cc1-c1nc2ccc(F)cc2o1",
        "output": "475"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1cc(S)cc(C(C)(C)C)c1O.CCCCCCl.CCO.CC[O-].O.[Na+]>>CCCCCSc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1",
        "output": "460"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccccc1-n1ccc2c(Cl)nc3c(C)cccc3c21.NCCO>>Cc1ccccc1-n1ccc2c(NCCO)nc3c(C)cccc3c21",
        "output": "110"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccccc1C1CC(=O)c2cc(O)ccc2O1.Oc1ccc2c(c1)C(O)CC(c1ccccc1)O2>>COc1ccccc1C1CC(O)c2cc(O)ccc2O1",
        "output": "24"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCNC(CC(=O)O)C1.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Br)cc1F.[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(c2cc(Br)ccc2[N+](=O)[O-])C(CC(=O)O)C1",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)n1cc(C(=O)O)c2cnc(Cl)cc21.CCN.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O.[Cl-].[Na+]>>CCNC(=O)c1cn(C(C)C)c2cc(Cl)ncc12",
        "output": "674"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.O=C(N1CCN(c2ccccc2OCC(F)(F)F)CC1)C(Cl)(Cl)Cl.O=S(=O)(O)Cl>>O=C(N1CCN(c2cc(S(=O)(=O)Cl)ccc2OCC(F)(F)F)CC1)C(Cl)(Cl)Cl",
        "output": "182"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCCNc1ccc(NC(=O)c2nccnc2C(=O)Nc2ccc(Cl)cn2)cc1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>O=C(Nc1ccc(NCCO)cc1)c1nccnc1C(=O)Nc1ccc(Cl)cn1",
        "output": "708"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)/C=C/c1ccc(OCc2nc(C)c(C)nc2C)c(OC)c1.O.[Na+].[OH-]>>COc1cc(/C=C/C(=O)O)ccc1OCc1nc(C)c(C)nc1C",
        "output": "122"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrC(Br)(Br)Br.CCOC(=O)CCCn1cc(C(=O)c2ccc(OC(CCO)c3ccccc3)cc2)c2ccccc21.ClCCl.O=C([O-])O.[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)CCCn1cc(C(=O)c2ccc(OC(CCBr)c3ccccc3)cc2)c2ccccc21",
        "output": "378"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#CCOc1cc(Cl)ncn1.CN(C)C=O.O=C([O-])[O-].Oc1c(F)cc(F)cc1F.[Cl-].[K+].[K+].[NH4+]>>CC#CCOc1cc(Oc2c(F)cc(F)cc2F)ncn1",
        "output": "668"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)NCCNc1ccccc1[N+](=O)[O-].CO.NN.O=S(=O)([O-])[O-].[Mg+2].[Ni]>>CC(C)(C)OC(=O)NCCNc1ccccc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1[C@H](CN)C[C@@H]2C[C@@H]21.Cc1nc2sccn2c1C(=O)O>>Cc1nc2sccn2c1C(=O)NC[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)OC(C)(C)C",
        "output": "697"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.COC(=O)c1ccc(C(C)(C)O)cc1.[Cl-].[H-].[NH4+].[Na+]>>COC(=O)c1ccc(C(C)(C)OC)cc1",
        "output": "140"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(-c5c(C)cc(O[Si](C)(C)C(C)(C)C)cc5C)ccc(F)c43)ccc21.[F-]>>COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(-c5c(C)cc(O)cc5C)ccc(F)c43)ccc21",
        "output": "754"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)C1CCN(c2nc(-c3ccc(Br)cc3)cs2)CC1.ClCCl.O.[Li+].[OH-]>>O=C(O)C1CCN(c2nc(-c3ccc(Br)cc3)cs2)CC1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN=C=NCCCN(C)C.COC(=O)[C@@H](N)CC(C)C.Cc1ccccc1-c1cc([N+](=O)[O-])ccc1C(=O)O.On1nnc2ccccc21>>COC(=O)[C@H](CC(C)C)NC(=O)c1ccc([N+](=O)[O-])cc1-c1ccccc1C",
        "output": "652"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CN1Cc2c(Cl)cc(Cl)cc2[C@H](c2ccccc2N)C1.O=C(Cl)CCCCl>>CN1Cc2c(Cl)cc(Cl)cc2[C@H](c2ccccc2NC(=O)CCCCl)C1",
        "output": "9"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC12CCC(=O)C=C1c1c(cc(O)c(Cl)c1Cl)C2.CCC12CCC(=O)C=C1c1c(cc(O)c(Cl)c1Cl)C2.CCOC(=O)C1(Br)CCCC1.CCOC(=O)CBr>>CCOC(=O)C1(Oc2cc3c(c(Cl)c2Cl)C2=CC(=O)CCC2(C)C3)CCCC1",
        "output": "305"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)CCCCOc1cccc(OCc2ccccc2)c1C=O.[K+].[OH-]>>O=Cc1c(OCCCCC(=O)O)cccc1OCc1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)C(C)(C)Sc1ccc(Br)cc1.CCCCCC.CN(C)C=O.[Li]CCCC>>CC(C)(C)OC(=O)C(C)(C)Sc1ccc(C=O)cc1",
        "output": "638"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC1(c2c[nH]c3c([N+](=O)[O-])cccc23)CCc2cc(F)ccc21.CCOCC.CI.CN(C)C=O.C[O-].[Na+]>>CCC1(c2cn(C)c3c([N+](=O)[O-])cccc23)CCc2cc(F)ccc21",
        "output": "191"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCN(CCCCC)C(=O)C(CCC(=O)OC)CS(=O)(=O)c1ccc(C(C)=O)cc1.CO.[Na+].[OH-]>>CCCCCN(CCCCC)C(=O)C(CCC(=O)O)CS(=O)(=O)c1ccc(C(C)=O)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CC(O)(C2CNCCN2)C1.CCN(C(C)C)C(C)C.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CC(O)(C2CN(S(=O)(=O)c3ccccc3[N+](=O)[O-])CCN2)C1",
        "output": "99"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.COc1cc(F)c([N+](=O)[O-])cc1OC.Cl[Sn]Cl>>COc1cc(N)c(F)cc1OC",
        "output": "202"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Nc1nc(C)c(-c2cc(S(=O)(=O)Cl)sc2Br)s1.CCN(C(C)C)C(C)C.ClCCl.OC1CCCNC1>>CC(=O)Nc1nc(C)c(-c2cc(S(=O)(=O)N3CCCC(O)C3)sc2Br)s1",
        "output": "798"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)CC(C(=O)OCOC(=O)C(C)(C)C)C(=O)OCc1ccccc1.CN(C)C=O.[H][H].[Pd]>>CC(C)CC(C(=O)O)C(=O)OCOC(=O)C(C)(C)C",
        "output": "186"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1ccc([N+](=O)[O-])cc1OCc1ccccc1.CCO.CCOC(C)=O.NN.[Ni]>>CC(=O)Nc1ccc(N)cc1OCc1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CN(C)C=O.COC(=O)C[C@H]1C[C@H](O)C1.[H-].[Na+]>>COC(=O)C[C@@H]1C[C@@H](OCc2ccccc2)C1",
        "output": "464"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNCC1.CC(=O)O.Cc1cc2c(cc1-c1cc(C=O)ccc1Cl)C(C)(C)CCC2(C)C.Cc1ccccc1.O.O=C1CSC(=O)N1>>Cc1cc2c(cc1-c1cc(C=C3SC(=O)NC3=O)ccc1Cl)C(C)(C)CCC2(C)C",
        "output": "761"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCI.CN(C)C=O.O.O=c1[nH]ccc2cc(Br)ccc12.[H-].[Na+]>>CCn1ccc2cc(Br)ccc2c1=O",
        "output": "302"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=O.Cc1cc(F)ccc1[C@H]1CCNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl.ClCCCl.[BH3-]OC(=O)C(OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>Cc1cc(F)ccc1[C@H]1CCN(C)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "217"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "NC(=O)c1ccc(-c2nn(-c3ccc(C(=O)O)cc3)c3ccccc23)cc1.O=S(=O)(O)O.O=[N+]([O-])O>>NC(=O)c1ccc(-c2nn(-c3ccc(C(=O)O)cc3)c3ccc([N+](=O)[O-])cc23)cc1",
        "output": "21"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(COC(=O)Cc2cccc(CC(N)=O)c2)cc1.CS(=O)(=O)Cl.c1ccncc1>>COc1ccc(COC(=O)Cc2cccc(CC#N)c2)cc1",
        "output": "172"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C(N)=O)N1CCN(Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1.Cc1nc2ccccc2[nH]1>>Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C(C)(C)C(N)=O)CC3)cc2n1",
        "output": "788"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CS(=O)(=O)Cl.Cc1ncc(Cl)cc1C(=O)N[C@@H]1CC[C@@H](CO)CC1.ClCCl.c1ccncc1>>Cc1ncc(Cl)cc1C(=O)N[C@@H]1CC[C@@H](COS(C)(=O)=O)CC1",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.CN1CCC(n2cc(N)cn2)CC1.COc1ccc(Nc2nc(Cl)ncc2[N+](=O)[O-])cc1>>COc1ccc(Nc2nc(Nc3cnn(C4CCN(C)CC4)c3)ncc2[N+](=O)[O-])cc1",
        "output": "992"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCCC1=O.Cc1cc([N+](=O)[O-])ccc1F.NCCCCCO.O.O=C([O-])[O-].[K+].[K+]>>Cc1cc([N+](=O)[O-])ccc1NCCCCCO",
        "output": "572"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cl.Cl.NCCNc1nc(N)nc2c1CCCc1ccccc1-2.Nc1ccnc(Cl)n1>>Nc1ccnc(NCCNc2nc(N)nc3c2CCCc2ccccc2-3)n1",
        "output": "544"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.O=Cc1ccc(Oc2nc3ncccc3s2)cc1.OCC1CNCCO1.[Na+]>>OCC1CN(Cc2ccc(Oc3nc4ncccc4s3)cc2)CCO1",
        "output": "567"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCOc1ccc(-c2c(CC)nc(CCC)n(Cc3ccc(-c4ccccc4C#N)cc3)c2=O)cc1.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCOc1ccc(-c2c(CC)nc(CCC)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c2=O)cc1",
        "output": "979"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COC(=O)c1cnc2c(C)cc(C)cc2c1-c1ccccc1Cl.Cl.O.[K+].[OH-]>>Cc1cc(C)c2ncc(C(=O)O)c(-c3ccccc3Cl)c2c1",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(=O)Nc1n[nH]c(-c2ccc(F)cc2)c1-c1ccncc1.CCOC(C)=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1ccccc1.Cl>>CCC(=S)Nc1n[nH]c(-c2ccc(F)cc2)c1-c1ccncc1",
        "output": "695"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCOC(=O)CCCBr.O=C([O-])[O-].O=C1CCc2cc(I)c(O)cc21.[Cs+].[Cs+]>>CCOC(=O)CCCOc1cc2c(cc1I)CCC2=O",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCCCCC.CCOC(C)=O.CO.COC(=O)c1ccc2cccc(OCCCCCC(=O)OC(C)(C)C)c2n1>>CC(C)(C)OC(=O)CCCCCOc1cccc2ccc(C(=O)O)nc12",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCc1cc(C#N)ccc1O.CCO.[Pd]>>CCCc1cc(C#N)ccc1O",
        "output": "116"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(C)=O.C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1nc(Cl)ccc1Br.Cl.FC1CNC1.O=C([O-])O.[Na+]>>C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1nc(N2CC(F)C2)ccc1Br",
        "output": "220"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C(=O)Cc1cc(F)c(OCC[C@@H]2C[C@@H]2C2CCN(C(=O)OCc3ccccc3)CC2)cc1F.CO.[H][H].[Pd]>>CN(C)C(=O)Cc1cc(F)c(OCC[C@@H]2C[C@@H]2C2CCNCC2)cc1F",
        "output": "428"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(Cl)cnc1Oc1ccc(F)c(F)c1.Cl.[Na+].[OH-]>>O=C(O)c1cc(Cl)cnc1Oc1ccc(F)c(F)c1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1c(C(C)=O)c(C)n(-c2ccc(O)c(C)c2C)c1C.CCBr.O=C([O-])[O-].[K+].[K+]>>CCOc1ccc(-n2c(C)c(C(C)=O)c(C(C)=O)c2C)c(C)c1C",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#Cc1ccc2cc(O)ccc2c1.C1CCOC1.CC(C)(C)OC(=O)/N=N/C(=O)OC(C)(C)C.OCCCN1CCOCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C#Cc1ccc2cc(OCCCN3CCOCC3)ccc2c1",
        "output": "550"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CO.COc1cc(C)c(C(=O)c2c(C(F)(F)F)cc(Cl)nc2Cl)c(OC)c1OC.[C].[Pd]>>COc1cc(C)c(C(=O)c2c(C(F)(F)F)ccnc2Cl)c(OC)c1OC",
        "output": "40"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.Cc1ccc(S(=O)(=O)OC[C@H]2COc3ccc(C(F)(F)F)cc3O2)cc1.NCCO>>OCCNC[C@H]1COc2ccc(C(F)(F)F)cc2O1",
        "output": "853"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1cccc(CN)c1.Cc1c(Cl)cccc1S(=O)(=O)Cl.ClCCl.c1ccncc1>>COC(=O)c1cccc(CNS(=O)(=O)c2cccc(Cl)c2C)c1",
        "output": "530"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)Cl.O=[N+]([O-])c1ccc(-c2nc3ccc(O)cc3s2)cc1.[H-].[Na+]>>CC(=O)Oc1ccc2nc(-c3ccc([N+](=O)[O-])cc3)sc2c1",
        "output": "111"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCc1cc(S(N)(=O)=O)ccc1O.CCO.CO.ClCCl.[H][H].[Pd]>>CCCc1cc(S(N)(=O)=O)ccc1O",
        "output": "116"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)CC1CCCC(C)C1.O.[Na+].[OH-]>>CC1CCCC(CC(=O)O)C1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cccc(C)c1C(=O)NCCC(C)N1CCC(N(Cc2cccc(Cl)c2)c2ccc(C(=O)O)cc2)CC1.Nc1ccccc1>>Cc1cccc(C)c1C(=O)NCCC(C)N1CCC(N(Cc2cccc(Cl)c2)c2ccc(C(=O)Nc3ccccc3)cc2)CC1",
        "output": "50"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(CC)c1ccc(Cl)c2nc(Cl)n(C)c12.Cc1cc(Br)cc(Cl)c1O>>CCC(CC)c1ccc(Cl)c2nc(Oc3c(C)cc(Br)cc3Cl)n(C)c12",
        "output": "542"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC1)CC(N)c1ccccc12.CCN(CC)CC.CN(C)c1ccncc1.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)N1CCC2(CC1)CC(NS(C)(=O)=O)c1ccccc12",
        "output": "742"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CN(C)CCN.Cc1cccc(Nc2nc(-c3ccncc3)c(C(=O)O)s2)c1.ClCCl.O=C(Cl)C(=O)Cl>>Cc1cccc(Nc2nc(-c3ccncc3)c(C(=O)NCCN(C)C)s2)c1",
        "output": "534"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.NN.O.O=C(O)c1ccc(OCc2cccc(Br)c2)cc1O>>NNC(=O)c1ccc(OCc2cccc(Br)c2)cc1O",
        "output": "55"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(O)CO.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.c1ccncc1>>Cc1ccc(S(=O)(=O)OCC(C)O)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.Cc1ccc2c(N3CC[C@@H](N)C3)nc(-c3c(O)cccc3F)nc2c1.O=C(Cl)O[C@H]1CCOC1>>Cc1ccc2c(N3CC[C@@H](NC(=O)O[C@H]4CCOC4)C3)nc(-c3c(O)cccc3F)nc2c1",
        "output": "94"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CS(C)=O.Nc1ccc(C(=O)O)c(N)n1.O.On1nnc2ccccc21.[Cl-].[NH4+]>>NC(=O)c1ccc(N)nc1N",
        "output": "704"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CN1CCCC1=O.Cc1ccc(C(=N)NO)cc1N.O.O=C(n1ccnc1)n1ccnc1>>Cc1nc(-c2ccc(C)c(N)c2)no1",
        "output": "895"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.C=CC(=O)Nc1ccccc1Nc1nc(Cl)ncc1C(=O)NC.CO.COc1cc(N2CCOCC2)ccc1N.Cc1ccc(S(=O)(=O)O)cc1.ClCCl>>C=CC(=O)Nc1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1C(=O)NC",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=C(c1ccccc1)c1ccc(N)c([N+](=O)[O-])c1.CCO.O.[Na+].[SH-]>>C=C(c1ccccc1)c1ccc(N)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Brc1ccc2c(c1)N(C1CCNCC1)CC2.Fc1ccc(CCBr)c(F)c1>>Fc1ccc(CCN2CCC(N3CCc4ccc(Br)cc43)CC2)c(F)c1",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.NCc1ncc(Br)cc1F>>CC(C)(C)OC(=O)NCc1ncc(Br)cc1F",
        "output": "631"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)CCCN(C)CC(C)Oc1ncnc2oc(-c3ccccc3)c(-c3ccc(OC)cc3)c12.[Na+].[OH-]>>COc1ccc(-c2c(-c3ccccc3)oc3ncnc(OC(C)CN(C)CCCC(=O)O)c23)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C(C)n1ccc(OC)c(C#N)c1=O.CN(C)C=O.O=C1CCC(=O)N1Br>>CCOC(=O)C(C)n1cc(Br)c(OC)c(C#N)c1=O",
        "output": "518"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(Cl)Cl.Nc1ccc2oc3c(c2c1)CCCCCC3.O=C(Cl)CCc1ccccc1>>O=C(CCc1ccccc1)Nc1ccc2oc3c(c2c1)CCCCCC3",
        "output": "9"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CN.O=S(=O)(CCCl)c1ccccc1>>CNCCS(=O)(=O)c1ccccc1",
        "output": "279"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(N)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(Cc3ccncc3)cc(C(=O)O)c2c1.F[P-](F)(F)(F)(F)F>>Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(Cc3ccncc3)cc(C(=O)NC3CCN(C(=O)OC(C)(C)C)CC3)c2c1",
        "output": "674"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C[C@]12C[C@H](c3ccc(C(O)C4CC4)cc3)C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@]2(O)C(F)(F)C(F)(F)F.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>C[C@]12C[C@H](c3ccc(C(=O)C4CC4)cc3)C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@]2(O)C(F)(F)C(F)(F)F",
        "output": "32"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1CCCC1=O.Cc1cc(C)c(-n2c(C)nc3c(NCCCl)cc(C)nc32)c(C)c1.NC1CCCCC1>>Cc1cc(C)c(-n2c(C)nc3c(NCCNC4CCCCC4)cc(C)nc32)c(C)c1",
        "output": "279"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)cc4[N+](=O)[O-])cc3)c2cc1OC.ClC(Cl)Cl.O.O=S([O-])([O-])=S.[Na+].[Na+]>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)cc4N)cc3)c2cc1OC",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCCCCCC(=O)Cl.Cc1cc(Br)cc(C)c1N>>CCCCCCC(=O)Nc1c(C)cc(Br)cc1C",
        "output": "9"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(C)=O.COC(=O)c1cccc(Cc2c[nH]c3cc(OCc4ccccc4)ccc23)c1.ClCCl.[Pd]>>COC(=O)c1cccc(Cc2c[nH]c3cc(O)ccc23)c1",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CCN(C(C)C)C(C)C.ClC(Cl)Cl.Cn1nccc1-c1csc(C(=O)O)c1.F[P-](F)(F)(F)(F)F.N[C@@H](Cc1c(F)cccc1F)C(=O)O.N[C@@H](Cc1ccc(F)cc1F)CN1C(=O)c2ccccc2C1=O>>Cn1nccc1-c1csc(C(=O)N[C@@H](Cc2ccc(F)cc2F)CN2C(=O)c3ccccc3C2=O)c1",
        "output": "736"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cccc(C2(O)CCCNC2)c1.O=C(Cl)c1ccc(Cl)cc1Cl>>COc1cccc(C2(O)CCCN(C(=O)c3ccc(Cl)cc3Cl)C2)c1",
        "output": "201"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)N(C)C.CN(C)C=O.Cn1ccc(C(=O)O)n1.Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)ccc1F.O=C(Cl)C(=O)Cl.O=C([O-])O.[Na+]>>Cn1ccc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2F)n1",
        "output": "844"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCl.O=[Cr](=O)([O-])Cl.OCCCc1ccc(C(F)(F)F)c(F)c1.c1cc[nH+]cc1>>O=CCCc1ccc(C(F)(F)F)c(F)c1",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCC2=NCCCN2CC1.Cl.Nc1c(F)c(F)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1.c1ccncc1.c1ncn(C2CNC2)n1>>Nc1c(F)c(N2CC(n3cncn3)C2)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1",
        "output": "676"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cccc(N)c1.Oc1ccc(Nc2cc(Cl)ncn2)cc1>>Cc1cccc(Nc2cc(Nc3ccc(O)cc3)ncn2)c1",
        "output": "161"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Oc1ccc2nc(N)sc2n1.O=C(Cl)C1CC1.c1ccncc1>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Oc1ccc2nc(NC(=O)C3CC3)sc2n1",
        "output": "553"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CO.COc1cc(C(=O)O)c(F)cc1N1CN2[C@@H](C1=O)[C@H](c1cccc(Cl)c1F)[C@@](C#N)(c1ccc(Cl)cc1F)[C@@H]2CC(C)(C)C.ClCCl.F[P-](F)(F)(F)(F)F.N>>COc1cc(C(N)=O)c(F)cc1N1CN2[C@@H](C1=O)[C@H](c1cccc(Cl)c1F)[C@@](C#N)(c1ccc(Cl)cc1F)[C@@H]2CC(C)(C)C",
        "output": "358"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC1CCN(c2cccnc2NC(=O)c2nc(-c3csc(N4CCOCC4)n3)cnc2N)CC1.ClCCl.O=C(O)C(F)(F)F>>Nc1ncc(-c2csc(N3CCOCC3)n2)nc1C(=O)Nc1ncccc1N1CCC(N)CC1",
        "output": "538"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)CCN(CCNC(=O)OC(C)(C)C)c1nc2cc(Cl)ccc2o1.CS(=O)(=O)O>>CC(=O)CCN(CCN)c1nc2cc(Cl)ccc2o1",
        "output": "538"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CS(=O)(=O)Cl.C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C4(CC#N)CN([C@H]5CC[C@@H](Oc6cc(CO)cc(C(F)(F)F)n6)CC5)C4)c3)ncnc21.ClCCl>>C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C4(CC#N)CN([C@H]5CC[C@@H](Oc6cc(COS(C)(=O)=O)cc(C(F)(F)F)n6)CC5)C4)c3)ncnc21",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC(C#N)(CO)CC1.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCC2(C#N)CCN(C(=O)OC(C)(C)C)CC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CCc1cccc(-c2c(Cl)cccc2C(O)(CCCN)[C@@H]2CCCN(C(=O)OC(C)(C)C)C2)c1.ClCCl>>CCc1cccc(-c2c(Cl)cccc2C(O)(CCCNC(C)=O)[C@@H]2CCCN(C(=O)OC(C)(C)C)C2)c1",
        "output": "339"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=S)N1c1ccc(-c2ccc(OCCOCCOCC(=O)O)cc2)cc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1.Cl.F[P-](F)(F)(F)(F)F.O>>Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOc2ccc(-c3ccc(N4C(=S)N(c5ccc(C#N)c(C(F)(F)F)c5)C(=O)C4(C)C)cc3)cc2)C(C)(C)C)cc1",
        "output": "133"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C)NC.O=C(O)c1cc(-c2ccccc2)c2ccccc2c1.O=S(Cl)Cl.c1ccncc1>>CCC(C)N(C)C(=O)c1cc(-c2ccccc2)c2ccccc2c1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1.[Li+].[OH-]>>O=C(O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CN(C)CCN.O=C(Cl)N1CCC(Oc2ccccc2)C1.c1ccncc1>>CN(C)CCNC(=O)N1CCC(Oc2ccccc2)C1",
        "output": "454"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.COc1cc(Cc2nc3c(ncn3C(CCCc3ccccc3)C(C)O)c(=O)[nH]2)ccc1OC(F)F.CS(C)=O.ClCCl.[Na+].[OH-]>>COc1cc(Cc2nc3c(ncn3C(CCCc3ccccc3)C(C)=O)c(=O)[nH]2)ccc1OC(F)F",
        "output": "87"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.CSCc1cccc2c(C(CCC#N)c3ccc(Cl)cc3Cl)c[nH]c12.ClCCl.O=C(OO)c1cccc(Cl)c1>>CS(=O)Cc1cccc2c(C(CCC#N)c3ccc(Cl)cc3Cl)c[nH]c12",
        "output": "13"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)N1CCNCC1.FC(F)(F)c1ccc(-c2ccc(Cl)nc2)cc1>>CC(C)N1CCN(c2ccc(-c3ccc(C(F)(F)F)cc3)cn2)CC1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Nc1ccc(I)cc1C(=O)O>>COC(=O)c1cc(I)ccc1N",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cccc2[nH]ccc12.ClCCl.O=C(Cl)C(Cl)(Cl)Cl.c1ccncc1>>COc1cccc2[nH]cc(C(=O)C(Cl)(Cl)Cl)c12",
        "output": "524"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN1CCCC1.N#Cc1cc([N+](=O)[O-])ccc1Cl.Nc1ccccc1>>N#Cc1cc([N+](=O)[O-])ccc1Nc1ccccc1",
        "output": "510"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(O)c1cc(OC2COC2)nc(-c2cccc(I)c2)n1.[Cl-].[NH4+]>>NC(=O)c1cc(OC2COC2)nc(-c2cccc(I)c2)n1",
        "output": "136"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COc1ccc2ncc(F)c(CCN3CC[C@@H](C(C)(C)N)C3)c2n1.ClCCl.O=Cc1ccc2c(n1)NC(=O)CS2>>COc1ccc2ncc(F)c(CCN3CC[C@@H](C(C)(C)NCc4ccc5c(n4)NC(=O)CS5)C3)c2n1",
        "output": "775"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)CCc1ccc(O)cc1.Cc1ccccc1O.Cc1ccccc1Oc1ccc(CO)cc1.O=Cc1ccc(Br)cc1>>COC(=O)CCc1ccc(OCc2ccc(Oc3ccccc3C)cc2)cc1",
        "output": "347"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(=O)(=O)Nc1cc(C(O)CN)ccc1O.N=C1NC(=O)C(=Cc2ccc(N3CCC(=O)CC3)cc2)S1>>CS(=O)(=O)Nc1cc(C(O)CNC2CCN(c3ccc(C=C4SC(=N)NC4=O)cc3)CC2)ccc1O",
        "output": "236"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)O.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.C[C@H](c1ccccc1)N1C[C@@](CCO[Si](C)(C)C(C)(C)C)(C(=O)OC(C)(C)C)C(F)C1=O.[F-]>>C[C@H](c1ccccc1)N1C[C@@](CCO)(C(=O)OC(C)(C)C)C(F)C1=O",
        "output": "708"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1ccc(I)cn1.CCOC(C)=O.CN1CCCC1=O.CN1CCCNCC1.O.O=C([O-])[O-].[K+].[K+]>>CN1CCCN(c2ccc(I)cn2)CC1",
        "output": "647"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=CCOC(=O)N1C[C@H](OS(C)(=O)=O)C[C@H]1C(=O)OC.CCO.O=S(=O)(O)O.[BH4-].[Na+]>>C=CCOC(=O)N1C[C@H](OS(C)(=O)=O)C[C@H]1CO",
        "output": "430"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)[C@@H](C(=O)O)N1Cc2ccc(-c3ccc(NC(=O)c4ccccc4)cc3)cc2C1=O.COC(=O)C1(N2Cc3ccc(-c4ccc(NC(=O)c5ccc(C)cc5)cc4)cc3C2=O)CCC1>>Cc1ccc(C(=O)Nc2ccc(-c3ccc4c(c3)C(=O)N(C3(C(=O)O)CCC3)C4)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].O=Cc1ccc(Br)c(F)c1F.OB(O)c1ccc(F)cc1F.[Na+].[Na+].[Pd].[Pd]>>O=Cc1ccc(-c2ccc(F)cc2F)c(F)c1F",
        "output": "837"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCc2oc(COc3ccccc3)nc2C1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])[O-].[Na+].[Na+]>>c1ccc(OCc2nc3c(o2)CCNC3)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CC(C(=O)O)c1ccc(CNS(C)(=O)=O)c(F)c1.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.Cc1cccc(-c2nc(C(C)(C)C)ccc2CN)c1.On1nnc2ccccc21>>Cc1cccc(-c2nc(C(C)(C)C)ccc2CNC(=O)C(C)c2ccc(CNS(C)(=O)=O)c(F)c2)c1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.ClC(Cl)Cl.OCC1CCNCC1>>CCOC(=O)N1CCC(CO)CC1",
        "output": "219"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Clc1nnc(Cl)c2ccccc12.[Na]>>COc1nnc(Cl)c2ccccc12",
        "output": "407"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1c2ccc(Cl)ccc-2[nH]c1=O.[Na+].[OH-]>>O=C(O)c1c2ccc(Cl)ccc-2[nH]c1=O",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[O-].Cc1ccc(C)cc1.Clc1cc(Cl)ncn1.Nc1cccc2cnccc12.[Na+]>>Clc1cc(Nc2cccc3cnccc23)ncn1",
        "output": "161"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCCCCCCCCCCBr.CC(C)=O.O=C(OCc1ccccc1)c1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>O=C(OCc1ccccc1)c1ccc(OCCCCCCCCCCCCBr)cc1",
        "output": "385"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=Cc1ccccc1OC(F)(F)F.O=S(=O)(O)O.O=[N+]([O-])O>>O=Cc1cc([N+](=O)[O-])ccc1OC(F)(F)F",
        "output": "21"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)CCN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@@H]1CCCN1CCc1ccc(-c2ccc(C3(C(=O)O)CCCC3)cc2)cc1.Cl.Cl.F[P-](F)(F)(F)(F)F>>CCOC(=O)CCNC(=O)C1(c2ccc(-c3ccc(CCN4CCC[C@H]4C)cc3)cc2)CCCC1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C.CC(C)(C)OC(=O)NCc1ccc(N2CC(C(=O)N3CCN(CCC(=O)OCc4ccccc4)CC3)OC2=O)cc1.CN(C)C=O.CO.ClCCl.[Pd]>>CC(C)(C)OC(=O)NCc1ccc(N2CC(C(=O)N3CCN(CCC(=O)O)CC3)OC2=O)cc1",
        "output": "186"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.ClCCl.O=C(Cl)C(Cl)=C(Cl)Cl>>CC(C)OC(=O)C(Cl)=C(Cl)Cl",
        "output": "320"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)P(=O)(N(C)C)N(C)C.N#Cc1ccc(N)cc1.O.OCCCCCCCCCCCCCCCCBr>>N#Cc1ccc(NCCCCCCCCCCCCCCCCO)cc1",
        "output": "273"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C(=N)N(C)C.ClCCl.NCC(O)c1ccccc1>>CC(C)(C)[Si](C)(C)OC(CN)c1ccccc1",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)O.CN(C)C=O.Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(=O)NCCC=O)c[nH]4)c3)cc2)c1.O.OCC1CCCNC1.[BH3-]C#N.[Na+]>>Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(=O)NCCCN5CCCC(CO)C5)c[nH]4)c3)cc2)c1",
        "output": "484"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(F)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.Nc1cccc2c(=O)n(Cc3ccc4c(c3)OCCO4)ccc12.O=C(O)CC1CCCCCC1>>O=C(CC1CCCCCC1)Nc1cccc2c(=O)n(Cc3ccc4c(c3)OCCO4)ccc12",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCCn2c1cc(Cl)nc2=O.OCCc1ccc(C(F)(F)F)cc1>>CN1CCCn2c1cc(OCCc1ccc(C(F)(F)F)cc1)nc2=O",
        "output": "653"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C1Cc2cc(S(=O)(=O)N3CCc4ccccc4C3)ccc2N1.O=Cc1cc2cc(OCCN3CCCC3)ccc2[nH]1>>O=C1Nc2ccc(S(=O)(=O)N3CCc4ccccc4C3)cc2C1=Cc1cc2cc(OCCN3CCCC3)ccc2[nH]1",
        "output": "440"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN.O.O=C(O)c1cccc2ccccc12.O=C([O-])O.O=S(Cl)Cl.[Na+]>>CCNC(=O)c1cccc2ccccc12",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "NCCc1ccc(C=CC2CCCCC2)cc1.Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O>>Nc1nc(NCCc2ccc(C=CC3CCCCC3)cc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O",
        "output": "544"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#Cc1cc(C(=O)Oc2ccc(CC(=O)OC(C)(C)C)c(F)c2)cc2c1OC(C)(C)CC2(C)C.C1COCCO1.O=CO>>C#Cc1cc(C(=O)Oc2ccc(CC(=O)O)c(F)c2)cc2c1OC(C)(C)CC2(C)C",
        "output": "278"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)COC1CCN(C(=O)OC(C)(C)C)CC1.CO.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(OCC(=O)O)CC1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)[C@H]1CN(CC#Cc2cccc(F)c2F)CC[C@H]1CCC(O)c1ccnc2ccc(OC)cc12.ClCCl.[Na+].[OH-]>>COc1ccc2nccc(C(O)CC[C@@H]3CCN(CC#Cc4cccc(F)c4F)C[C@@H]3C(=O)O)c2c1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)O.CO.COC(=O)[C@H](CNC(=O)OC(C)(C)C)NC(=O)c1ccc(C#Cc2ccc(NC(=O)CNC(=O)OC(C)(C)C)cc2)cc1.C[O-].Cl.ClC(Cl)Cl.NO.[Na+]>>CC(C)(C)OC(=O)NCC(=O)Nc1ccc(C#Cc2ccc(C(=O)N[C@@H](CNC(=O)OC(C)(C)C)C(=O)NO)cc2)cc1",
        "output": "376"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.ClCc1ccccc1.O.O=C([O-])[O-].O=Cc1cc(F)c(O)c(F)c1.[K+].[K+]>>O=Cc1cc(F)c(OCc2ccccc2)c(F)c1",
        "output": "49"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNC1.CCN(CC)CC.CCOP(=O)(C#N)OCC.O=C(O)CCc1nccn1CCCCc1ccc(OCc2coc(/C=C/c3ccc(C(F)(F)F)cc3)n2)cc1>>O=C(CCc1nccn1CCCCc1ccc(OCc2coc(/C=C/c3ccc(C(F)(F)F)cc3)n2)cc1)N1CCCC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2nc(C3=NOC(c4ccccc4)C3)cs2)CC1.CCOCC.CO.Cl.ClCCl>>c1ccc(C2CC(c3csc(C4CCNCC4)n3)=NO2)cc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Br.COc1c(Cl)cc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3-c3ccccc3)CC2)cc1Cl>>CS(=O)(=O)c1ccc(-c2ccccc2)c(C(=O)N2CCN(c3cc(Cl)c(O)c(Cl)c3)CC2)c1",
        "output": "402"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC(C)/C=C/C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cc(N2CCNCC2)c2ccccc2n1.F[P-](F)(F)(F)(F)F>>CCCC(C)/C=C/C(=O)N1CCN(c2cc(OC)nc3ccccc23)CC1",
        "output": "870"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccc2ccccc2c1.ClCCl.O.c1c[nH]cn1>>c1ccc2cc(Cn3ccnc3)ccc2c1",
        "output": "593"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "NCc1ccc(Br)cc1.O=C(Cl)c1ccc(Cl)c([N+](=O)[O-])c1>>O=C(NCc1ccc(Br)cc1)c1ccc(Cl)c([N+](=O)[O-])c1",
        "output": "411"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O.COc1ccc(S(=O)(=O)Cl)cc1>>COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NS(=O)(=O)c4ccc(OC)cc4)cc3)cc2C1=O",
        "output": "68"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNCC1.CCO.Clc1nc(Cl)c2cc[nH]c2n1>>Clc1nc(N2CCCCC2)c2cc[nH]c2n1",
        "output": "540"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cl.ClC(Cl)Cl.NCCc1cccc2ccccc12.O.O=C(Cl)C1CCC1.O=C([O-])[O-].[K+].[K+]>>O=C(NCCc1cccc2ccccc12)C1CCC1",
        "output": "45"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(CCl)C(=O)Cl.Fc1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(CCl)C(=O)c1ccc(F)cc1",
        "output": "31"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1c(C(=O)O)ccc(F)c1F.ClCCl.O=S(Cl)Cl>>Cc1c(C(=O)Cl)ccc(F)c1F",
        "output": "3"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC(C)(C)C(=O)O.CCN(CC)CC.CCOC(=O)N1c2ccccc2C=CC1OCC.CSc1ccccc1-c1ccc(N)c(F)c1.ClC(Cl)Cl>>CSc1ccccc1-c1ccc(NC(=O)C(C)(C)NC(=O)OC(C)(C)C)c(F)c1",
        "output": "365"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1cc(S)cc(C(C)(C)C)c1O.CCO.OCCCl.[K+].[OH-].c1ccccc1>>CC(C)(C)c1cc(SCCO)cc(C(C)(C)C)c1O",
        "output": "460"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)c1ccc(CS(=O)c2ccc(OC)c(C34CC5CC(CC(C5)C3)C4)c2)cc1.[Na+].[OH-]>>COc1ccc(S(=O)Cc2ccc(C(=O)O)cc2)cc1C12CC3CC(CC(C3)C1)C2",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCc1cc(OC)cc2cc(-c3ccc(OC)cc3)oc12.Cl.O=C1CC[C@@H](C(=O)O)N1>>CCCc1cc(O)cc2cc(-c3ccc(O)cc3)oc12",
        "output": "20"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.Cl[Pd]Cl.Nc1ncc(Br)cc1-c1nc2ccccc2s1.O.O=C([O-])[O-].OB(O)c1cccc(O)c1.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Nc1ncc(-c2cccc(O)c2)cc1-c1nc2ccccc2s1",
        "output": "833"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCO.Cn1ncc2c(Cl)cc(-c3cccc(C#N)c3F)nc21.NN>>Cn1ncc2c(Cl)cc(-c3cccc4c(N)n[nH]c34)nc21",
        "output": "945"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCCN1CCOCC1.O=c1oc2c(c(O)c1-c1ccccc1)CCCC2>>O=c1oc2c(c(OCCCN3CCOCC3)c1-c1ccccc1)CCCC2",
        "output": "74"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC1(C)OB(c2cncc(F)c2)OC1(C)C.CCO.Cc1ccccc1.Cl[Pd]Cl.O.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cncc(Br)c1.O=P([O-])([O-])[O-].[Fe+2].[K+].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1cncc(-c2cncc(F)c2)c1",
        "output": "967"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COc1ccc(CC(NC(=O)OCc2ccccc2)c2nc3cncnc3[nH]2)cc1.N#N.[Pd]>>COc1ccc(CC(N)c2nc3cncnc3[nH]2)cc1",
        "output": "574"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)CBr.CN(C)C=O.O.O=C([O-])[O-].O=Cc1cccc(O)c1.[K+].[K+]>>CCOC(=O)COc1cccc(C=O)c1",
        "output": "123"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.Clc1ccc2c(N3CCNCC3)ccnc2c1.Clc1nc2ccccc2[nH]1.O>>Clc1ccc2c(N3CCN(c4nc5ccccc5[nH]4)CC3)ccnc2c1",
        "output": "36"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCC2=NCCCN2CC1.C1CCOC1.NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1.O=C(O)c1ccc(Cl)s1.O=C(n1ccnc1)n1ccnc1>>O=C(NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1)c1ccc(Cl)s1",
        "output": "736"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCOc1ccc(O)cc1-c1nc(CC)c(CC)c(=O)[nH]1.CS(=O)(=O)Cl>>CCCOc1ccc(OS(C)(=O)=O)cc1-c1nc(CC)c(CC)c(=O)[nH]1",
        "output": "149"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Oc1ccc(Oc2ccc(C3=CC=CN4CCS(=O)(=O)N=C34)cc2)cc1.CCCC[N+](CCCC)(CCCC)CCCC.[Cl-].[F-].[NH4+]>>O=S1(=O)CCN2C=CC=C(c3ccc(Oc4ccc(O)cc4)cc3)C2=N1",
        "output": "754"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.CCCN.CCN(CC)CC.O=C1CCc2cc(Cl)c(S(=O)(=O)Cl)cc21>>CCCNS(=O)(=O)c1cc2c(cc1Cl)CCC2=O",
        "output": "43"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)CC(=O)Cl.COc1c(C)ccc(C(=O)Oc2ccc(C(=O)CNC(C)C)cc2O)c1Cl.C[O-].[Na+].[Na+].[O-]c1ccccc1>>COc1c(C)ccc(C(=O)Oc2ccc(C(=O)CNC(C)C)cc2OC(=O)CC(C)C)c1Cl",
        "output": "111"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Nc1ccccn1.O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Cl)c1.O=C([O-])[O-].[Cs+].[Cs+]>>O=C(Nc1cnccc1-c1ccccc1)c1ccnc(Nc2ccccn2)c1",
        "output": "606"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCC[C@@H](O)C(F)(F)F.CCN(CC)CC.CN(C)c1ccccn1.ClCCl.O=C(Cl)c1ccc(OCc2ccccc2)cc1>>CCCCCC[C@@H](OC(=O)c1ccc(OCc2ccccc2)cc1)C(F)(F)F",
        "output": "51"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cl.ClCCl.F[B-](F)(F)F.NC12CC(C1)C2.O.O=C(O)c1cc(Br)cnc1F>>O=C(NC12CC(C1)C2)c1cc(Br)cnc1F",
        "output": "674"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCN(C(=O)Oc2ccc([N+](=O)[O-])cc2)CC1.CNCCOC>>COCCN(C)C(=O)N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "770"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O=CCc1ccc(F)c(F)c1.[BH4-].[Na+]>>OCCc1ccc(F)c(F)c1",
        "output": "223"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COc1cc(C(=O)O)c(F)cc1N.C[Si](C)(C)C=[N+]=[N-].ClCCl>>COC(=O)c1cc(OC)c(N)cc1F",
        "output": "195"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)C1CCC(c2ncc(-c3ccc(N)cc3)s2)CC1.COC(=O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1.O=C=Nc1cccc(Cl)c1F>>COC(=O)C1CCC(c2ncc(-c3ccc(NC(=O)Nc4cccc(Cl)c4F)cc3)s2)CC1",
        "output": "473"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CO.COc1cccc(CN2CCC(N(C)C(=O)n3cnc(-c4cccc([N+](=O)[O-])c4)c3)CC2)c1.[Pd]>>COc1cccc(CN2CCC(N(C)C(=O)n3cnc(-c4cccc(N)c4)c3)CC2)c1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)Cc1c(C)n(S(=O)(=O)c2ccc(Cl)c(Cl)c2)c2ncccc12.[Na+].[OH-]>>Cc1c(CC(=O)O)c2cccnc2n1S(=O)(=O)c1ccc(Cl)c(Cl)c1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.Cc1nc(Cl)cc2c1c(I)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1.O=[Se]=O>>O=Cc1nc(Cl)cc2c1c(I)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "619"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)c1ccc([C@H]2C[C@H](NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)C[C@@H](c3ccccc3)O2)c(F)c1.[Li+].[OH-]>>O=C(O)c1ccc([C@H]2C[C@H](NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)C[C@@H](c3ccccc3)O2)c(F)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CNCCN1.CC(C)(C)OC(=O)Nc1ncc(Br)nc1-c1nnc(-c2ccccc2)o1.CN(C)C=O>>CC(C)(C)OC(=O)Nc1ncc(N2CCNCC2)nc1-c1nnc(-c2ccccc2)o1",
        "output": "211"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCC(=O)O.CCN=C=NCCCN(C)C.CCOCC.Cl.ClCCl.NCCc1cccc([N+](=O)[O-])c1>>CCCCCCC(=O)NCCc1cccc([N+](=O)[O-])c1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=C(CCO)[C@H]1CC[C@H]2[C@@H](O[Si](C)(C)C(C)(C)C)CCC[C@]12C.CC(C)(C)[Si](C)(C)Cl.ClCCl.c1c[nH]cn1>>C=C(CCO[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H](O[Si](C)(C)C(C)(C)C)CCC[C@]12C",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCc1c(O)ccc2c1OCC2=O.CN(C)C=O.COC(=O)CCc1ccccc1OCCCCCBr.O=C([O-])[O-].[K+].[K+]>>CCCc1c(OCCCCCOc2ccccc2CCC(=O)OC)ccc2c1OCC2=O",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)C(=O)COc1cccc([C@@H](CN2CC[C@H](O)C2)NC)c1.CN(C)C=O.O=C(O)Cc1ccc2sc(=O)[nH]c2c1.On1nnc2ccccc21>>CCN(CC)C(=O)COc1cccc([C@@H](CN2CC[C@H](O)C2)N(C)C(=O)Cc2ccc3sc(=O)[nH]c3c2)c1",
        "output": "633"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C(=O)OC(C)(C)C)n1ccccc1=O.Cl>>CC(C(=O)O)n1ccccc1=O",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCN1CCNCC1.O.O=Cc1ccccc1>>CC(C)(C)OC(=O)NCCN1CCNCC1",
        "output": "631"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COC(=O)c1ccc(CC#N)cc1Br.O=S(=O)([O-])O.[K+].[Na+].[OH-]>>N#CCc1ccc(C(=O)O)c(Br)c1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COc1ccc(-c2cnc3c(c2)c(-c2cnn(CCc4ccc(F)cc4)c2)cn3S(=O)(=O)c2ccc(C)cc2)cc1NS(C)(=O)=O.O.[Li+].[OH-]>>COc1ccc(-c2cnc3[nH]cc(-c4cnn(CCc5ccc(F)cc5)c4)c3c2)cc1NS(C)(=O)=O",
        "output": "949"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C(O[Si](C)(C)C(C)(C)C)c1ccc(-c2ncc(Cl)c(Nc3cc(C4CC4)[nH]n3)n2)s1.[Na+].[OH-]>>CC(C)(C)[Si](C)(C)OC(C(=O)O)c1ccc(-c2ncc(Cl)c(Nc3cc(C4CC4)[nH]n3)n2)s1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1cccc(Br)c1.CN(C)C=O.Cc1cc(NC(=O)CS(=O)(=O)c2c[nH]c3cc(F)cc(F)c23)no1.[H-].[Na+]>>Cc1cc(NC(=O)CS(=O)(=O)c2cn(Cc3cccc(Br)c3)c3cc(F)cc(F)c23)no1",
        "output": "528"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N1CCC2(C1)CN(C(=O)Nc1ncc(Cl)s1)c1ccc(OCCCC(=O)O)cc12.CN.Cl>>CNC(=O)CCCOc1ccc2c(c1)C1(CCN(C(C)=O)C1)CN2C(=O)Nc1ncc(Cl)s1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C[C@H]1CN(c2ccccc2)CCN1.O=C1C2CCCN2C(=O)N1CCCCBr>>C[C@H]1CN(c2ccccc2)CCN1CCCCN1C(=O)C2CCCN2C1=O",
        "output": "73"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COc1ccc(-c2sc3ccccc3c2C(=O)c2ccc(OCCN3CCCC3)nc2)cc1.ClCCl>>O=C(c1ccc(OCCN2CCCC2)nc1)c1c(-c2ccc(O)cc2)sc2ccccc12",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O.OCCI.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCI",
        "output": "193"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=C(CC(=O)N1CCC(Oc2ccccc2[N+](=O)[O-])CC1)Nc1ccc(-c2ccccc2)cc1.[Pd]>>Nc1ccccc1OC1CCN(C(=O)CC(=O)Nc2ccc(-c3ccccc3)cc2)CC1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.Cl[Pd]Cl.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.O.O=C([O-])[O-].O=[N+]([O-])c1cc(Br)cc(C(F)(F)F)c1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cn1cc(-c2cc([N+](=O)[O-])cc(C(F)(F)F)c2)cn1",
        "output": "971"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(C(=O)O)c1ccccc1.CS(=O)(=O)Nc1ccccc1.O>>CCC(C(=O)c1ccc(NS(C)(=O)=O)cc1)c1ccccc1",
        "output": "435"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)c1ccn2c(Br)cnc2n1.CC1(C)OB(c2ccc(F)c(-c3ccccc3C#N)c2)OC1(C)C>>CC(C)c1ccn2c(-c3ccc(F)c(-c4ccccc4C#N)c3)cnc2n1",
        "output": "937"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1c(C=O)[nH]c2c1C(=O)N(CCN1CCOCC1)CC2.O=C1Cc2c(cccc2-c2cccc(F)c2F)N1>>Cc1c(C=C2C(=O)Nc3cccc(-c4cccc(F)c4F)c32)[nH]c2c1C(=O)N(CCN1CCOCC1)CC2",
        "output": "440"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC=O.COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCCNCc2ccccc2)CC1.[BH3-]C#N.[Na+]>>CCN(CCCCCCN1CCC(CNC(=O)c2cc(Cl)c(N)cc2OC)CC1)Cc1ccccc1",
        "output": "858"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=O.Cl.O=C(NCC1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1>>CN1CCCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)CC(c2ccccc2)(c2ccccc2)c2ccccc2)C1",
        "output": "217"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.COc1ccc(Cc2ccc(C(N)=O)cc2O)cc1.ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1ccc(Cc2ccc(C#N)cc2O)cc1",
        "output": "374"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN.CN(C)c1ccncc1.Cl.Cl.ClCCl.NC(=O)c1c(F)ccc(OC(C(=O)O)c2nc(-c3ccc(Cl)cc3)c(Cl)o2)c1F.O.On1nnc2ccccc21>>CNC(=O)C(Oc1ccc(F)c(C(N)=O)c1F)c1nc(-c2ccc(Cl)cc2)c(Cl)o1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCC.CCO.CCOC(C)=O.Cl[Sn]Cl.Cn1ncc(Br)c1-c1cc(N2CCCC2)cc([N+](=O)[O-])c1.O.O>>Cn1ncc(Br)c1-c1cc(N)cc(N2CCCC2)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1Cc2cc(-c3ccc(-c4cncc(N)c4)s3)ccc2C1=O.O=S(=O)(Cl)c1ccccc1Br>>CN1Cc2cc(-c3ccc(-c4cncc(NS(=O)(=O)c5ccccc5Br)c4)s3)ccc2C1=O",
        "output": "554"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1cc(Cl)ccc1Cl.O=C(O)c1cc(Cl)ccc1O>>O=C(Nc1cc(Cl)ccc1Cl)c1cc(Cl)ccc1O",
        "output": "50"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cn1nc(C#N)c([N+](=O)[O-])c1N.[H][H].[Pd]>>Cn1nc(C#N)c(N)c1N",
        "output": "628"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.CCCCc1nc2cc(-c3ccccc3)nn2c(=O)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCCCc1nc2cc(-c3ccccc3)nn2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1",
        "output": "815"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)n1c(C(=O)O)cc2cccc(F)c21.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(C3CNCCO3)cc12.F[P-](F)(F)(F)(F)F.O>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(C3CN(C(=O)c4cc5cccc(F)c5n4C(=O)OC(C)(C)C)CCO3)cc12",
        "output": "605"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1nc(C(=O)O)c(-c2cccc(F)c2)s1.O=C(NC[C@@H]1C[C@@H]2C[C@@H]2N1)c1cccc2occc12>>Nc1nc(C(=O)N2[C@H](CNC(=O)c3cccc4occc34)C[C@@H]3C[C@@H]32)c(-c2cccc(F)c2)s1",
        "output": "747"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cc([N+](=O)[O-])cc(-c3ccnc(F)c3)n2)CC1.NC1CCCCC1>>CC(C)(C)OC(=O)N1CCN(c2cc([N+](=O)[O-])cc(-c3ccnc(NC4CCCCC4)c3)n2)CC1",
        "output": "810"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccc(F)cc1Nc1ncccc1F>>Nc1ccc(F)cc1Nc1ncccc1F",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1=C(C#N)[C@@H](c2ccc(C#N)cc2)n2nc(NCC(=O)OC(C)(C)C)nc2N1c1cccc(C(F)(F)F)c1.ClCCl.O=C(O)C(F)(F)F>>CC1=C(C#N)[C@@H](c2ccc(C#N)cc2)n2nc(NCC(=O)O)nc2N1c1cccc(C(F)(F)F)c1",
        "output": "278"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCCC=O.CO.NC(=O)c1ccc(F)c2c1CC(NCCCc1c[nH]c3ccc(F)cc13)CO2.[BH3-]C#N.[BH3-]C#N.[Na+].[Na+]>>CCCCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2c(F)ccc(C(N)=O)c2C1",
        "output": "484"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(NS(C)(=O)=O)ccc1/C=C/c1cc(-c2cccnc2OCc2ccccc2)cc(C(C)(C)C)c1.[Li+].[OH-]>>CC(C)(C)c1cc(/C=C/c2ccc(NS(C)(=O)=O)cc2C(=O)O)cc(-c2cccnc2OCc2ccccc2)c1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)C=O.C[C@H]1CNC[C@@H](C)O1.NC(=O)c1cc(Br)cc2c3ccc(C(=O)O)cc3n(CC3CC3)c12>>C[C@H]1CN(C(=O)c2ccc3c4cc(Br)cc(C(N)=O)c4n(CC4CC4)c3c2)C[C@@H](C)O1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.Nc1cc(-c2nc3cccnc3[nH]2)cc(-c2ncccc2Cl)c1.[Cl-].[NH4+]>>CS(=O)(=O)Nc1cc(-c2nc3cccnc3[nH]2)cc(-c2ncccc2Cl)c1",
        "output": "194"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "NCCCCN1CCC(=C2c3ccccc3CSc3sccc32)CC1.O=C(O)CCc1cccnc1.O=C(n1ccnc1)n1ccnc1>>O=C(CCc1cccnc1)NCCCCN1CCC(=C2c3ccccc3CSc3sccc32)CC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCc1nc(C)c(-c2ccc3c(c2)C(O)CC(C)(C)O3)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CI.CN(C)C=O.[H-].[Na+]>>CCCc1nc(C)c(-c2ccc3c(c2)C(OC)CC(C)(C)O3)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "140"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCCCC(C)(C#N)C(=O)O.CCCCCCCc1nnc(-c2ccc(O)cc2)s1.ClCCl>>CCCCCCCc1nnc(-c2ccc(OC(=O)C(C)(C#N)CCCC)cc2)s1",
        "output": "108"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)c1ccc(-c2ccccc2)cc1NC(=O)c1ccc(-c2ccccc2)cn1.O=C(O)C(F)(F)F>>O=C(Nc1cc(-c2ccccc2)ccc1C(=O)O)c1ccc(-c2ccccc2)cn1",
        "output": "752"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.COC1CCN(C2CCNCC2)CC1.Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc(C)c1O>>COC1CCN(C2CCN(C(=O)[C@@H](Cc3cc(C)c(O)c(C)c3)OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Br.CCOC(=O)c1nc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n2c1Cn1cnc(Cl)c1Cl>>O=C(O)c1nc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n2c1Cn1cnc(Cl)c1Cl",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(=O)(=O)Cl.Cc1ccc(NC(=O)Nc2nc(CCN)cs2)c(C(=O)C2CCCC2)c1.ClCCl.c1ccncc1>>Cc1ccc(NC(=O)Nc2nc(CCNS(C)(=O)=O)cs2)c(C(=O)C2CCCC2)c1",
        "output": "493"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CO.O.O=S([O-])OO.O=S([O-])[O-].Oc1ccc([C@@H]2Oc3ccc(O)cc3[C@@H]3CSC[C@H]23)cc1.[K+].[Na+].[Na+]>>O=S1(=O)C[C@H]2c3cc(O)ccc3O[C@@H](c3ccc(O)cc3)[C@H]2C1",
        "output": "847"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCn2c1cc(Cl)nc2=O.OCc1ccc(Oc2ccnc(C(F)(F)F)c2)cc1.[H-].[Na+]>>CN1CCn2c1cc(OCc1ccc(Oc3ccnc(C(F)(F)F)c3)cc1)nc2=O",
        "output": "653"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CSc1cc(Cl)cc(Cl)c1.Cl.O=C=O.[Li]CCCC>>CSc1cc(Cl)c(C(=O)O)c(Cl)c1",
        "output": "387"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1cc(F)ccc1[N+](=O)[O-].O.O=C([O-])[O-].[K+].[K+].c1cn[nH]c1>>Cc1cc(-n2cccn2)ccc1[N+](=O)[O-]",
        "output": "751"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCO.CN(C)CC(O)COc1ccc(N)cc1.CO.Cl.Fc1ccc(Nc2ccnc(Cl)n2)c(F)c1.N>>CN(C)CC(O)COc1ccc(Nc2nccc(Nc3ccc(F)cc3F)n2)cc1",
        "output": "907"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCCCC.FC(F)(F)c1cc(Cl)c(-n2ccc3ccccc32)c(Cl)c1.O=C1CCC(=O)N1Br.c1ccncc1>>FC(F)(F)c1cc(Cl)c(-n2cc(Br)c3ccccc32)c(Cl)c1",
        "output": "796"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCN(CC)CC.CCOC(=O)c1ccc2c(c1)N(CC(=O)O)C(=O)CO2.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CNC(CN1CCCC1)c1ccc(-c2ccccc2)cc1.ClCCl.F[P-](F)(F)(F)(F)F.O.O=C(O)C(F)(F)F>>CCOC(=O)c1ccc2c(c1)N(CC(=O)N(C)C(CN1CCCC1)c1ccc(-c3ccccc3)cc1)C(=O)CO2",
        "output": "633"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.Nc1cc([N+](=O)[O-])ccc1Cl.O=C(Cl)CCl.c1ccncc1>>O=C(CCl)Nc1cc([N+](=O)[O-])ccc1Cl",
        "output": "9"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CC(C)c1cc(-c2ccccc2O)c(C#N)c(N2CCN(C(=O)c3ccoc3)[C@H](C)C2)n1>>CC(=O)Oc1ccccc1-c1cc(C(C)C)nc(N2CCN(C(=O)c3ccoc3)[C@H](C)C2)c1C#N",
        "output": "111"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "NC(=O)c1cc(F)cc2[nH]c(-c3ccc(C4CCCN(C(=O)OCc5ccccc5)C4)cc3F)nc12.O=C(O)C(F)(F)F>>NC(=O)c1cc(F)cc2[nH]c(-c3ccc(C4CCCNC4)cc3F)nc12",
        "output": "428"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=C(O)c1ccc(N2C(=O)CSC2=S)cc1.O=Cc1ccccc1.[Cl-].[NH4+].[NH4+].[OH-]>>O=C(O)c1ccc(N2C(=O)C(=Cc3ccccc3)SC2=S)cc1",
        "output": "314"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)C1CCN(c2nn(C(=O)c3c(Cl)cccc3C3CC3)c3cccc(F)c23)CC1O.Cl.O.[Li+].[OH-]>>O=C(O)C1CCN(c2nn(C(=O)c3c(Cl)cccc3C3CC3)c3cccc(F)c23)CC1O",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.CCOC(=O)CC1Cc2ccc(OC)cc2Oc2ccccc21.CO.ClCCl>>CCOC(=O)CC1Cc2ccc(O)cc2Oc2ccccc21",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.O=[N+]([O-])c1ccc(CCN2CCCCC2)cc1>>Nc1ccc(CCN2CCCCC2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Brc1cccc2[nH]ccc12.CC(=O)O.CO.[BH3-]C#N.[Na+]>>Brc1cccc2c1CCN2",
        "output": "672"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cncc(B2OC(C)(C)C(C)(C)O2)c1.Nc1c2c(nc3c(Br)cccc13)CN(C1CCC1)C2=O>>COc1cncc(-c2cccc3c(N)c4c(nc23)CN(C2CCC2)C4=O)c1",
        "output": "967"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CC(=O)Cl.Nc1nccn2c([C@@H]3CCCCN3)nc(-c3ccc(C(=O)Nc4cc(F)ccn4)cc3)c12>>C=CC(=O)N1CCCC[C@H]1c1nc(-c2ccc(C(=O)Nc3cc(F)ccn3)cc2)c2c(N)nccn12",
        "output": "135"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccc(Cl)c(OCC2CCCO2)c1.[Pd]>>Nc1ccc(Cl)c(OCC2CCCO2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCC1CCNCC1.CO.ClCCl.O=C([O-])[O-].O=C1COc2c(F)cccc2N1CCCCl.[I-].[K+].[K+].[Na+]>>CCCCC1CCN(CCCN2C(=O)COc3c(F)cccc32)CC1",
        "output": "138"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCBr.CCCCBr.O=Cc1ccc(O)c(Cl)c1.O=Cc1ccc(O)cc1>>CCCCOc1ccc(C=O)cc1Cl",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COC(=O)c1ccc(N2CCN(Cc3cnc4c(c3)NC(=O)[C@@H]3CCCCN43)CC2)cc1.[Li+].[OH-]>>O=C(O)c1ccc(N2CCN(Cc3cnc4c(c3)NC(=O)[C@@H]3CCCCN43)CC2)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Clc1ccc2ncc(-c3cc4ccccc4o3)n2n1.NCC(O)C1CC1.[H-].[Na+]>>NCC(Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1)C1CC1",
        "output": "407"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2ccc(O)cc2)CC1.CC(C)=O.CCN(CC)CCCl.Cl.O=C([O-])[O-].[K+].[K+]>>CCN(CC)CCOc1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1",
        "output": "74"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)SCC(C)C(=O)N(CC(=O)O)C1CCCCC1.N>>CC(CS)C(=O)N(CC(=O)O)C1CCCCC1",
        "output": "90"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCCCCNS(=O)(=O)c1ccc(-c2ccccc2)cc1.O=C1Nc2ccccc2N[C@H]1Cc1ccccc1>>NCCCCNS(=O)(=O)c1ccc(-c2ccccc2)cc1",
        "output": "538"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.COc1ccc(S(=O)(=O)Cl)cc1C(C)(C)C.ClCCl.O.c1nc(C2CC2)cnc1O[C@@H]1C[C@H]2CNCCN2C1>>COc1ccc(S(=O)(=O)N2CCN3C[C@H](Oc4cnc(C5CC5)cn4)C[C@H]3C2)cc1C(C)(C)C",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)CC(Cc1nc(C(=O)NCCCNc2ccccn2)co1)c1ccccc1.O.[Li+].[OH-]>>O=C(O)CC(Cc1nc(C(=O)NCCCNc2ccccn2)co1)c1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)c1cc(S(=O)(=O)Nc2ccccc2F)c(Cl)cc1Cl.Cl.O.[Na+].[OH-]>>O=C(O)c1cc(S(=O)(=O)Nc2ccccc2F)c(Cl)cc1Cl",
        "output": "5"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC)CC.COc1ccccc1CNc1nc(Cl)nc(Cl)n1.ClCCl.NCCOc1ccccc1>>COc1ccccc1CNc1nc(Cl)nc(NCCOc2ccccc2)n1",
        "output": "578"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)CC(Sc1nnc(-c2ccccc2)[nH]1)C(=O)O.CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.N#CCN.O>>CC(C)CC(Sc1nnc(-c2ccccc2)[nH]1)C(=O)NCC#N",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCCO.CCCc1nc2cnc3cc(Br)ccc3c2n1CCCC(C)=O.O=C([O-])[O-].OB(O)c1ccccc1.[Na+].[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCc1nc2cnc3cc(-c4ccccc4)ccc3c2n1CCCC(C)=O",
        "output": "909"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)CCSCc1cccc(C(=O)O)c1.CN(C)c1ccncc1.Cc1cccc(CNc2cc(-c3cc(N4CCCCC4)ccc3N)ncn2)c1.ClCCl>>Cc1cccc(CNc2cc(-c3cc(N4CCCCC4)ccc3NC(=O)c3cccc(CSCCC(=O)OC(C)(C)C)c3)ncn2)c1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CNC(=O)c1cn(C)c(=O)c2c(-c3ccccc3)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)oc12.ClCCl.O=C(O)C(F)(F)F>>CNC(=O)c1cn(C)c(=O)c2c(-c3ccccc3)c(-c3ccc(C4(N)CCC4)cc3)oc12",
        "output": "793"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCc1oc2ccccc2c1C(=O)NCc1ccc2c(-c3ccc(C)cc3)c(O)ccc2c1.CCOC(C)=O.CN(C)C=O.N#CCBr.O=C([O-])[O-].[K+].[K+]>>CCCCc1oc2ccccc2c1C(=O)NCc1ccc2c(-c3ccc(C)cc3)c(OCC#N)ccc2c1",
        "output": "802"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CCc1nc2c(C)cc(C)nc2n1Cc1ccc(/C=C/C(=O)OC)cc1.O.[K+].[OH-]>>CCc1nc2c(C)cc(C)nc2n1Cc1ccc(/C=C/C(=O)O)cc1",
        "output": "58"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)NCCNC(C)C.CCOC(=O)c1ccc(N)cn1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.ClC(Cl)Cl.F[P-](F)(F)(F)(F)F.O=C(O)CCCc1ccc(-c2ccccc2)c(NC(=O)OC23CCN(CC2)CC3)c1>>CCOC(=O)c1ccc(NC(=O)CCCc2ccc(-c3ccccc3)c(NC(=O)OC34CCN(CC3)CC4)c2)cn1",
        "output": "724"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.Cl.O.O=C(Cl)OCc1ccccc1.OC1CNC1.[Na+].[OH-]>>O=C(OCc1ccccc1)N1CC(O)C1",
        "output": "427"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)NC1(C(=O)O)CCCCC1.CO.ClCCl>>COC(=O)C1(NC(=O)OC(C)(C)C)CCCCC1",
        "output": "195"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.CNCc1cccs1.ClCCl.O=C(O)C1(c2ccc(F)cc2)CCCC1>>CN(Cc1cccs1)C(=O)C1(c2ccc(F)cc2)CCCC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)C(=O)Cl.CCN(CC)CC.COc1ccc(F)c([C@@H]2C[C@H]2CN)c1.ClCCl>>COc1ccc(F)c([C@@H]2C[C@H]2CNC(=O)C(C)C)c1",
        "output": "45"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC1CCN(c2cncc(-c3c[nH]c4ccc(-c5ccccc5F)nc34)c2)CC1.CO.Cl.ClCCl>>NC1CCN(c2cncc(-c3c[nH]c4ccc(-c5ccccc5F)nc34)c2)CC1",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN.CO.O=S1(=O)N(CCCBr)c2ccccc2N1c1ccc(F)cc1F>>CNCCCN1c2ccccc2N(c2ccc(F)cc2F)S1(=O)=O",
        "output": "147"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CI.OC1C2C=CC1C1N=NC21.[H-].[Na+]>>COC1C2C=CC1C1N=NC21",
        "output": "140"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.ClCCl.Cn1ccc2c3nc(-c4cccc(CN)c4)nc(N4CCOCC4)c3ccc21>>CC(=O)NCc1cccc(-c2nc(N3CCOCC3)c3ccc4c(ccn4C)c3n2)c1",
        "output": "206"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1cc(C(F)(F)F)cnc1Cl>>Nc1cc(C(F)(F)F)cnc1Cl",
        "output": "269"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.CC(=O)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C(=O)O>>CC(=O)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C(=O)N1CCOCC1",
        "output": "517"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCC(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.NC(=O)[C@@H]1CC[C@@H](N)CO1>>CC(C)(C)OC(=O)NCC(=O)N[C@@H]1CC[C@@H](C(N)=O)OC1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(Oc1ccc(C(=O)O)cc1)c1ccccn1.O=S(Cl)Cl>>CC(Oc1ccc(C(=O)Cl)cc1)c1ccccn1",
        "output": "3"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COC(=O)Cc1ccc(O)c(C)c1.ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)Cc1ccc(OS(=O)(=O)C(F)(F)F)c(C)c1",
        "output": "731"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O.OCc1ccnc(Cl)c1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCc1ccnc(Cl)c1",
        "output": "193"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1n[nH]c2c1CN(Cc1ccccc1)C2.[Pd]>>CCOC(=O)c1n[nH]c2c1CNC2",
        "output": "84"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CN1CCNCC1.O=C([O-])[O-].O=[N+]([O-])c1ccccc1CCl.[K+].[K+]>>CN1CCN(Cc2ccccc2[N+](=O)[O-])CC1",
        "output": "156"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)NS(=O)(=O)c1cccc(-c2cn(-c3nc(-c4ccc(Cl)s4)cc(C(F)(F)F)n3)cn2)c1.ClCCl.O=C(O)C(F)(F)F>>NS(=O)(=O)c1cccc(-c2cn(-c3nc(-c4ccc(Cl)s4)cc(C(F)(F)F)n3)cn2)c1",
        "output": "680"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(C)=O.COC(=O)c1ccc([N+](=O)[O-])c(F)c1.[Pd]>>COC(=O)c1ccc(N)c(F)c1",
        "output": "772"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCC(CNC)c1ccc(F)cc1.CCN(C(C)C)C(C)C.ClCCl.N#Cc1cc(C(=O)Cl)c2ccccc2c1>>C=CCC(CN(C)C(=O)c1cc(C#N)cc2ccccc12)c1ccc(F)cc1",
        "output": "201"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1cnc(N2CCN(Cc3ccccc3)CC2)cn1.CCOCC.Cl>>Nc1ccccc1NC(=O)c1cnc(N2CCN(Cc3ccccc3)CC2)cn1",
        "output": "782"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N1CCc2cc(Br)cc([N+](=O)[O-])c21.CCO.Cl.O=C([O-])[O-].[Na+].[Na+]>>O=[N+]([O-])c1cc(Br)cc2c1NCC2",
        "output": "504"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCCCCCCCCCCNc1ccc(C(=O)O)c(F)c1.CCOCC.CCOCCO.Cc1ccccc1.FB(F)F>>CCCCCCCCCCCCCCCCNc1ccc(C(=O)OCCOCC)c(F)c1",
        "output": "33"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.Cc1cnc(Cl)c(C)n1.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccc2ccccc2c1.[Na+].[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cnc(-c2ccc3ccccc3c2)c(C)n1",
        "output": "875"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc(Cl)nc1.Cn1nnc(-c2ccccc2)c1CO.O.[H-].[Na+]>>COC(=O)c1ccc(OCc2c(-c3ccccc3)nnn2C)nc1",
        "output": "433"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(C)=O.CO.COC(=O)c1ccc(CS(C)(=O)=O)cc1.Cc1ccccc1.O.O=C([O-])C(O)C(O)C(=O)[O-].[H-].[K+].[Na+]>>CS(=O)(=O)Cc1ccc(CO)cc1",
        "output": "444"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.Nc1cccc(Br)n1>>Nc1cccc(N2CCOCC2)n1",
        "output": "647"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(=O)Cl.Cl.NC(CCC(=O)O)C(F)F.[Na+].[OH-]>>CC(=O)NC(CCC(=O)O)C(F)F",
        "output": "45"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1c(-c2cccc(C)n2)nn2ccccc12.[Na+].[OH-]>>Cc1cccc(-c2nn3ccccc3c2C(=O)O)n1",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCc1ccc(B(O)O)cc1.Cc1noc(-c2ccc(Br)cc2)c1C=O>>CCOC(=O)CCc1ccc(-c2ccc(-c3onc(C)c3C=O)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=C(Nc1ccc([N+](=O)[O-])cn1)N1CCCC1.[Pd]>>Nc1ccc(NC(=O)N2CCCC2)nc1",
        "output": "269"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Nc1nc(C2CC2)nc(C(=O)O)c1Cl.O=S(Cl)Cl>>COC(=O)c1nc(C2CC2)nc(N)c1Cl",
        "output": "331"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc(N)cc1NC(=O)c1cc2nccnc2s1.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccnc(Br)c1>>Cc1ccc(NC(=O)c2ccnc(Br)c2)cc1NC(=O)c1cc2nccnc2s1",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.O=C([O-])O.O=Cc1ccccn1.[Na+].[Na+].c1cnc(-c2ccncc2)c(OC2CCNCC2)c1>>c1ccc(CN2CCC(Oc3cccnc3-c3ccncc3)CC2)nc1",
        "output": "829"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNC1.CCN(CC)CC.CCN=C=NCCCN(C)C.COc1cc(C(=O)O)ccc1N.ClCCl.O.O.Oc1cccc2[nH]nnc12>>COc1cc(C(=O)N2CCCC2)ccc1N",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](N)[C@H](F)C1.CCN(CC)CC.CCN=C=NCCCN(C)C.CCc1[nH]c(C(=O)O)nc1Cl.Cl.O.On1nnc2ccccc21>>CCc1[nH]c(C(=O)N[C@@H]2CCN(C(=O)OC(C)(C)C)C[C@H]2F)nc1Cl",
        "output": "951"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.COCCl.ClCCl.O=S(=O)([O-])O.Oc1ccc(Br)cc1Cl.[K+]>>COCOc1ccc(Br)cc1Cl",
        "output": "375"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)Cc1cscc1C(=O)O.Cl.O.[K+].[OH-]>>O=C(O)Cc1cscc1C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.CCOC(=O)CCn1cnc2c(=O)[nH]cnc21.CCOCC.Cn1cccc1CCN>>Cn1cccc1CCNC(=O)CCn1cnc2c(=O)[nH]cnc21",
        "output": "64"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN.CN(C)C=O.ClCCl.O=C(O)COc1cccc2ccccc12.On1nnc2ccccc21>>CNC(=O)COc1cccc2ccccc12",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.Clc1ccc(CBr)cc1.O.OCCO.[H-].[I-].[Na+]>>OCCOCc1ccc(Cl)cc1",
        "output": "464"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C(=O)Cl.C[Si](C)(C)C#N.O=C1CCCc2c1ccc[n+]2[O-]>>N#Cc1ccc2c(n1)CCCC2=O",
        "output": "720"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.CC(=O)c1ccc2c(c1)C(C)(C)CCO2.CCOC(C)=O.CO.O>>CC1(C)CCOc2ccc(C(=O)CBr)cc21",
        "output": "173"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "N[C@@H]1CC[C@@H](C(=O)c2nc3ccccc3s2)CC1.O=Cc1ccc2c(c1)OCCO2>>O=C(c1nc2ccccc2s1)[C@@H]1CC[C@@H](NCc2ccc3c(c2)OCCO3)CC1",
        "output": "468"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCNC(=O)COCc1ccc(F)cc1.CC#N.CCN(CC)CC.COc1cc(NS(=O)(=O)c2ccc(C#CCNC(=O)COCc3ccc(F)cc3)cc2)cc(OC)c1OC.COc1ccc(NS(=O)(=O)c2ccc(I)cc2)cc1OCCN(C)C.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>COc1ccc(NS(=O)(=O)c2ccc(C#CCNC(=O)COCc3ccc(F)cc3)cc2)cc1OCCN(C)C",
        "output": "664"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.O=C(OCc1ccccc1)N1CCN(c2ccc(OC3CCNCC3)cc2)C(=O)C1.O=C1CCC1.[Na+]>>O=C(OCc1ccccc1)N1CCN(c2ccc(OC3CCN(C4CCC4)CC3)cc2)C(=O)C1",
        "output": "187"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C(=O)Cl.CCN(CC)CC.CCOCc1nc2c(N)nc3cc(-c4cccnc4)ccc3c2n1CCN>>CCOCc1nc2c(N)nc3cc(-c4cccnc4)ccc3c2n1CCNC(=O)C(C)C",
        "output": "45"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CNCCN1.CC(C)(C)O[Na].CC(C)Oc1cccc(OC(C)C)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1ccccc1.Cc1nc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)nn1Cc1cccc(Br)c1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]>>Cc1nc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)nn1Cc1cccc(N2CCNCC2)c1",
        "output": "953"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClC(Cl)Cl.NCC1CCOCC1.O.O=C(O)c1cc(COCc2cccc(SC(F)(F)F)c2)on1.On1nnc2ccccc21>>O=C(NCC1CCOCC1)c1cc(COCc2cccc(SC(F)(F)F)c2)on1",
        "output": "696"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CS(C)=O.Cc1c(Cl)cccc1CCl.[C-]#N.[Na+]>>Cc1c(Cl)cccc1CC#N",
        "output": "38"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN1CCC(F)(CO)CC1.ClCCl.NS(=O)(=O)c1ccc(F)c(S(=O)(=O)C(F)(F)F)c1.O.[H-].[Na+]>>CN1CCC(F)(COc2ccc(S(N)(=O)=O)cc2S(=O)(=O)C(F)(F)F)CC1",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC1(CO)COC1.CCN(CC)CC.CS(=O)(=O)Cl.Cc1ccccc1.O=C([O-])O.[Na+]>>CCC1(COS(C)(=O)=O)COC1",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CC(C)C[AlH]CC(C)C.CCN(CC)CC.CCn1cc(C(=O)O)c(=O)c2c(Cl)c(OCc3ccc(OC)cc3)c(OCc3ccc(OC)cc3)cc21.Cc1ccccc1>>CCn1cc(CO)c(=O)c2c(Cl)c(OCc3ccc(OC)cc3)c(OCc3ccc(OC)cc3)cc21",
        "output": "293"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C(N(C)C)=[N+]1N=Nc2ncccc21.CN(C)C=O.Cl.NCC1CCC(F)(F)CC1.O=C(O)c1cn(CC2CCOC2)c2nccc(Cl)c12>>O=C(NCC1CCC(F)(F)CC1)c1cn(CC2CCOC2)c2nccc(Cl)c12",
        "output": "674"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(C)=O.Cl.O=C([O-])O.O=[N+]([O-])c1ccc(Oc2cc3cnn(C4CCCCO4)c3cc2-c2ccncc2)c(F)c1.[Na+]>>O=[N+]([O-])c1ccc(Oc2cc3cn[nH]c3cc2-c2ccncc2)c(F)c1",
        "output": "689"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NC(C)(C)C(=O)O.CCOCC.CN1CCNCC1[Al+]C1CNCCN1C.[H-]>>CC(C)(CO)NC(=O)OC(C)(C)C",
        "output": "231"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc(Nc2cc(Cl)nc(-c3cc4ccccc4o3)n2)n[nH]1.NC1CCOCC1>>Cc1cc(Nc2cc(NC3CCOCC3)nc(-c3cc4ccccc4o3)n2)n[nH]1",
        "output": "166"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.Cc1ccc(S(=O)(=O)OCC(C)(O)Cn2cc([N+](=O)[O-])nc2Cl)cc1.FC(F)(F)c1ccc(OC2CCNCC2)cc1.O.[I-].[Na+]>>CC(O)(CN1CCC(Oc2ccc(C(F)(F)F)cc2)CC1)Cn1cc([N+](=O)[O-])nc1Cl",
        "output": "429"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrBr.CC(=O)O.O=C1C(=O)N2CCSc3cccc1c32>>O=C1C(=O)N2CCSc3cc(Br)cc1c32",
        "output": "98"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCCC[Sn](CCCC)(CCCC)c1ccc(CNC(=O)CCC(=O)O)cc1C(OCOC)(C(F)(F)F)C(F)(F)F.CCN=C=NCCCN(C)C.O=C1CCC(=O)N1O>>CCCC[Sn](CCCC)(CCCC)c1ccc(CNC(=O)CCC(=O)ON2C(=O)CCC2=O)cc1C(OCOC)(C(F)(F)F)C(F)(F)F",
        "output": "303"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(Br)cc1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>BrCc1ccc(Br)cc1",
        "output": "29"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.ClC(Cl)Cl.O=C1CSc2ccc(CO)cc2N1>>O=Cc1ccc2c(c1)NC(=O)CS2",
        "output": "179"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C1(NC(=O)C(NC(=O)Cn2nc(-c3ccc(Cl)s3)n(CCOC)c2=O)c2cccc(C(F)(F)F)c2)CC1.CO.Cl.O.[Li+].[OH-]>>COCCn1c(-c2ccc(Cl)s2)nn(CC(=O)NC(C(=O)NC2(C(=O)O)CC2)c2cccc(C(F)(F)F)c2)c1=O",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCN(c2ccc(N)cc2C(F)(F)F)CC1.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C>>COc1cc(C(=O)Nc2ccc(N3CCN(C)CC3)c(C(F)(F)F)c2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "50"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN1CCCC1=O.CNc1nc(Cl)nc2c1CCC2c1ccccc1.COc1cc(N)ccc1Br.O.O=S(=O)(O)O>>CNc1nc(Nc2ccc(Br)c(OC)c2)nc2c1CCC2c1ccccc1",
        "output": "808"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCOc1ccccc1.CC#N.O=C([O-])[O-].O=[N+]([O-])c1cn[nH]c1.[Cs+].[Cs+]>>O=[N+]([O-])c1cnn(CCOc2ccccc2)c1",
        "output": "577"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CN(C)C=O.Fc1c(Br)ccc2c1OCCO2.[Li]CCCC>>O=Cc1ccc2c(c1F)OCCO2",
        "output": "638"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CN(C)C=O.COCCNCc1ccccc1.Cc1ccccc1.ClCCl.O=C(O)c1cc(-c2ccc(OCc3ccccc3)cc2)c(=O)n2ccc3ccsc3c12.O=S(Cl)Cl>>COCCN(Cc1ccccc1)C(=O)c1cc(-c2ccc(OCc3ccccc3)cc2)c(=O)n2ccc3ccsc3c12",
        "output": "893"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CON.Cl.O=C(Cc1ccc(Cl)cc1)c1ccccc1.c1ccncc1>>CON=C(Cc1ccc(Cl)cc1)c1ccccc1",
        "output": "212"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CC(C)(C)OC(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(c3c(OCc4ccccc4)c(=O)c3=O)CS[C@H]12.Cc1ccc(S(=O)(=O)O)cc1.O>>NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(c3c(OCc4ccccc4)c(=O)c3=O)CS[C@H]12",
        "output": "431"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cc1cc([N+](=O)[O-])cc(C)c1Oc1ccc(O)c(S(=O)(=O)CC2CC2)c1>>Cc1cc(N)cc(C)c1Oc1ccc(O)c(S(=O)(=O)CC2CC2)c1",
        "output": "335"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc2ncnc(Cl)c2cc1O.OCCCN1CCCC1>>COc1cc2ncnc(Cl)c2cc1OCCCN1CCCC1",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1c(Cl)ccc(-c2ccccc2)c1Cl.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>Clc1ccc(-c2ccccc2)c(Cl)c1CBr",
        "output": "29"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCOC(=O)C=Cc1ccc(OCC=C)c([N+](=O)[O-])c1.C=CCOC(=O)Cc1ccc(OCC=C)c([N+](=O)[O-])c1>>C=CCOC(=O)Cc1ccc(OCC=C)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.O=C(CBr)c1ccsc1.O=S(=O)(CC1CNC1)c1ccc(F)cc1>>O=C(CN1CC(CS(=O)(=O)c2ccc(F)cc2)C1)c1ccsc1",
        "output": "413"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)Cl.CN(C)C=O.NCC1CCCO1.O=C(O)c1c[nH]c2ccccc2c1=O.[Cl-].[NH4+]>>O=C(NCC1CCCO1)c1c[nH]c2ccccc2c1=O",
        "output": "674"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.Nc1ccc(C2CCOCC2)cc1.O.O=N[O-].[Na+]>>Brc1ccc(C2CCOCC2)cc1",
        "output": "373"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)O.COc1cc(Cl)nc(Cl)n1.[Zn+2].c1cnc(-c2cc([C@@H]3CCCN3)on2)nc1>>COc1cc(Cl)nc(N2CCC[C@H]2c2cc(-c3ncccn3)no2)n1",
        "output": "36"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1ccc(C2CC(C(=O)O)CN(C(=O)N3CCOCC3)C2)cc1.N=C(NO)c1cccc(OC(F)(F)F)c1>>CCc1ccc(C2CC(c3nc(-c4cccc(OC(F)(F)F)c4)no3)CN(C(=O)N3CCOCC3)C2)cc1",
        "output": "895"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCc1cc(CCC=O)nn1C(C)(C)C.CCN(C(C)C)C(C)C.Clc1ccc(N2CCNCC2)cc1Cl.[Na+]>>CCCc1cc(CCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)nn1C(C)(C)C",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(-c2ccc(Cl)cc2)cc(=O)[nH]1.O=P(Cl)(Cl)Cl>>Cc1cc(-c2ccc(Cl)cc2)cc(Cl)n1",
        "output": "100"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.Cc1cc(OC(C)c2ccc(-c3ccc(C(F)(F)F)cc3)nc2C)ccc1SCC(=O)OC(C)(C)C.[Na+].[OH-]>>Cc1cc(OC(C)c2ccc(-c3ccc(C(F)(F)F)cc3)nc2C)ccc1SCC(=O)O",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)c1ccncc1.COc1ccc(CO[C@@H]2[C@@H](N=[N+]=[N-])[C@H](SC)O[C@H](CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)[C@H]2O)cc1.ClCCCl.O=C(Cl)c1ccccc1-c1ccccc1>>COc1ccc(CO[C@@H]2[C@@H](N=[N+]=[N-])[C@H](SC)O[C@H](CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)[C@H]2OC(=O)c2ccccc2-c2ccccc2)cc1",
        "output": "51"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.O.O=C1CCC(=O)N1Br.OCCCc1cccc(Cl)c1F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Fc1c(Cl)cccc1CCCBr",
        "output": "581"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)Oc1ccc(Br)cc1C(C)(C)C.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>COC(=O)Oc1cc([N+](=O)[O-])c(Br)cc1C(C)(C)C",
        "output": "21"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC1CCCN1.O.O=C([O-])[O-].OC1CCCc2sc(-c3ccc(OCCCCl)cc3)nc21.[I-].[K+].[K+].[Na+]>>CC1CCCN1CCCOc1ccc(-c2nc3c(s2)CCCC3O)cc1",
        "output": "138"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.COc1cc(Cl)c(C=O)cc1O.Cl.ClCCN1CCOCC1.O=C([O-])[O-].[K+].[K+]>>COc1cc(Cl)c(C=O)cc1OCCN1CCOCC1",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCOc1ccc2c(c1)C(c1ccc(OC)cc1OCOC)C(C(=O)OC)C2c1ccc2c(c1)OCO2.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCOc1ccc2c(c1)C(c1ccc(OC)cc1OCOC)C(CO)C2c1ccc2c(c1)OCO2",
        "output": "343"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCOCOCC.COc1ccc(B(O)O)cc1C=O.Cl.Clc1ccncc1.O=C([O-])[O-].[K+].[K+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(-c2ccncc2)cc1C=O",
        "output": "947"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)O.CCOC(C)=O.COC(=O)CCc1ccc(OC)c(-c2ccc(N3CCC3)nc2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)c1.O.[Li+].[OH-]>>COc1ccc(CCC(=O)O)cc1-c1ccc(N2CCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.Cl.ClCCl.N[C@@H]1CCOc2c(F)cccc21.O=[N+]([O-])c1cnc(Cl)nc1Cl>>O=[N+]([O-])c1cnc(Cl)nc1N[C@@H]1CCOc2c(F)cccc21",
        "output": "165"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCCC.CCOC(=O)c1cn(Cc2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)cc1-c1ccccn1.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>Cc1oc(-c2ccccc2)nc1COc1ccc(Cn2cc(CO)c(-c3ccccn3)c2)cc1",
        "output": "383"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(Cc1ccccc1)C(C)(C)CCC(C(N)=O)(c1ccccc1)c1ccccc1.CO.O=CO.[Pd]>>CNC(C)(C)CCC(C(N)=O)(c1ccccc1)c1ccccc1",
        "output": "84"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)C(CC1CCCC1)n1ncc(Oc2ccccc2C#N)cc1=O.[Na+].[OH-]>>N#Cc1ccccc1Oc1cnn(C(CC2CCCC2)C(=O)O)c(=O)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CCCCC=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCNC1.[Na+]>>C#CCCCCN1CC[C@@H](C(C(N)=O)(c2ccccc2)c2ccccc2)C1",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCI.Clc1ccc(Sc2c[nH]nc2I)cc1.O=C([O-])[O-].[K+].[K+]>>CCn1cc(Sc2ccc(Cl)cc2)c(I)n1",
        "output": "346"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1.C[Si](C)(C)I.Cl.ClC(Cl)Cl.[Na+].[OH-]>>Clc1ccc2c(c1)CCc1cccnc1C2=C1CCNCC1",
        "output": "283"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.CC(C)(C)c1ccc2c(c1)CCN(c1cccc(Cl)c1CO)C2=O.ClCCl.c1ccncc1>>CC(=O)OCc1c(Cl)cccc1N1CCc2cc(C(C)(C)C)ccc2C1=O",
        "output": "254"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1ccc([C@H](C)NC(=O)c2c(Cl)sc(Cl)c2C(O)c2cccc(Cl)c2)cc1.Cl>>C[C@H](NC(=O)c1c(Cl)sc(Cl)c1C(O)c1cccc(Cl)c1)c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "B.C1CCOC1.C1CCOC1.COc1cc(C(=O)O)c(F)cn1>>COc1cc(CO)c(F)cn1",
        "output": "72"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)Cc1sc(-c2nc(-c3ccc(CCN)cc3)no2)cc1C.O=C(O)CCO>>CCN(CC)Cc1sc(-c2nc(-c3ccc(CCNC(=O)CCO)cc3)no2)cc1C",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COc1cc(Nc2cc3c(-c4ccc(F)cc4)c(OC4CCN(C(=O)OC(C)(C)C)CC4)ccc3cn2)cc(OC)c1OC.Cl>>COc1cc(Nc2cc3c(-c4ccc(F)cc4)c(OC4CCNCC4)ccc3cn2)cc(OC)c1OC",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=S(=O)(Cl)c1ccccc1.c1cc2c(cc1-c1cnn(C3CCCCO3)c1)ncn2CC1CCNCC1>>O=S(=O)(c1ccccc1)N1CCC(Cn2cnc3cc(-c4cnn(C5CCCCO5)c4)ccc32)CC1",
        "output": "99"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCN(Cc2cc3c(N4CCOCC4)nc(Cl)nc3s2)CC1.C[C@H](O)C(=O)O.Cl.N#Cc1ccc(-c2nc(N3CCOCC3)c3cc(CN4CCNCC4)sc3n2)cn1>>C[C@H](O)C(=O)N1CCN(Cc2cc3c(N4CCOCC4)nc(-c4ccc(C#N)nc4)nc3s2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)CCNC(=O)COc1ccc2c(c1)CC(NS(=O)(=O)c1ccc(Cl)cc1)C2.[Na+].[OH-]>>O=C(O)CCNC(=O)COc1ccc2c(c1)CC(NS(=O)(=O)c1ccc(Cl)cc1)C2",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CC[C@H](C)Oc1cc(OCc2ccccc2)cc(C(=O)O)c1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cn1ccc(N)n1.F[P-](F)(F)(F)(F)F>>CC[C@H](C)Oc1cc(OCc2ccccc2)cc(C(=O)Nc2ccn(C)n2)c1",
        "output": "917"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(CF)C(=O)C(Oc1cccc(F)n1)n1cncn1.CO.[BH4-].[Na+]>>CC(C)(CF)C(O)C(Oc1cccc(F)n1)n1cncn1",
        "output": "91"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.OCCc1nc(-c2ccc(F)cc2)oc1-c1ccsc1>>CS(=O)(=O)OCCc1nc(-c2ccc(F)cc2)oc1-c1ccsc1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)c1ccc(C=Cc2ccccc2Cl)cc1.[Na+].[OH-]>>O=C(O)c1ccc(C=Cc2ccccc2Cl)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccc2ccc(O[C@@H]3CCC[C@H]3O[Si](C)(C)C(C)(C)C)cc2n1.[Cl-].[F-].[NH4+]>>Cc1ccc2ccc(O[C@@H]3CCC[C@H]3O)cc2n1",
        "output": "708"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.COc1ccc(C(C)=O)cc1O.Cc1cccc(C)c1CCl.O=C([O-])[O-].[K+].[K+]>>COc1ccc(C(C)=O)cc1OCc1c(C)cccc1C",
        "output": "49"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)CCN.COc1cc(Nc2cncc(-c3ccc(O)cc3)n2)c(Cl)cc1C(=O)O.F[B-](F)(F)F>>COc1cc(Nc2cncc(-c3ccc(O)cc3)n2)c(Cl)cc1C(=O)NCCN(C)C",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#CC(C)(C)O.C1CCOC1.CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.Cc1ncc[nH]1.Cc1nccn1Cc1c(C(N)=O)nc2n1CCOc1ccc(Br)cc1-2.OCc1c(I)nc2n1CCOc1ccc(Br)cc1-2.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1nccn1Cc1c(C(N)=O)nc2n1CCOc1ccc(C#CC(C)(C)O)cc1-2",
        "output": "659"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc(-c2ccc3[nH]ccc3c2)cc1.CN(C)C=O.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>O=Cc1c[nH]c2ccc(-c3ccc(Br)cc3)cc12",
        "output": "266"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(C)=O.Clc1cccnc1Cl.O.O=C([O-])[O-].SCc1ccccc1.[K+].[K+]>>Clc1cccnc1SCc1ccccc1",
        "output": "333"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.CC(C)(C)c1cc2cc(NC(=O)C3(c4ccc5c(c4)OCO5)CC3)cc(CN)c2[nH]1.CCN(CC)CC.CN(C)C=O>>CC(=O)NCc1cc(NC(=O)C2(c3ccc4c(c3)OCO4)CC2)cc2cc(C(C)(C)C)[nH]c12",
        "output": "206"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=c1[nH]c2ncc([N+](=O)[O-])cc2o1.[Pd]>>Nc1cnc2[nH]c(=O)oc2c1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COc1cc(OC2CCN(C)CC2)ccc1[N+](=O)[O-].[Pd]>>COc1cc(OC2CCN(C)CC2)ccc1N",
        "output": "202"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.COc1cccc(COc2ccc(Br)cc2C(=O)O)c1.Cl.Nc1cccnc1.On1nnc2ccccc21>>COc1cccc(COc2ccc(Br)cc2C(=O)Nc2cccnc2)c1",
        "output": "759"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1noc(-c2ccc(Br)cc2)c1Nc1nnc(Cc2ccccc2)o1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4Nc4nnc(Cc5ccccc5)o4)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)c1noc(C(C)C)c1COc1ccc(CC(=O)O)cc1.Cc1ccc(C(N)c2ccccc2)c(C)c1>>Cc1ccc(C(NC(=O)Cc2ccc(OCc3c(C(C)C)noc3C(C)C)cc2)c2ccccc2)c(C)c1",
        "output": "769"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Fc1cc(Br)ccn1.NCCN1CCCC1>>Brc1ccnc(NCCN2CCCC2)c1",
        "output": "810"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1=COCCC1.C=CCc1cc(OC)c2ccccc2c1O.Cl.ClCCl.O=C([O-])O.[Na+].c1cc[nH+]cc1>>C=CCc1cc(OC)c2ccccc2c1OC1CCCCO1",
        "output": "319"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.CNc1cc(-c2cccnc2Cl)ncn1.Cc1ccc2c(=O)[nH]ccc2c1N.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Pd].[Pd]>>CNc1cc(-c2cccnc2Nc2c(C)ccc3c(=O)[nH]ccc23)ncn1",
        "output": "434"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN1CCOCC1.CS(=O)(=O)Cl.ClCCl.Nc1ccc(-c2cnc(N)c(OCc3c(Cl)cccc3Cl)c2)cc1>>CS(=O)(=O)Nc1ccc(-c2cnc(N)c(OCc3c(Cl)cccc3Cl)c2)cc1",
        "output": "194"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)CN1C(=O)Cc2cc(NS(C)(=O)=O)ccc21.Cl>>CS(=O)(=O)Nc1ccc2c(c1)CC(=O)N2CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CNCc1ccccc1.ClCCl.O=C(O)c1cccnc1SCCS(=O)(=O)c1ccccc1.O=C(n1ccnc1)n1ccnc1>>CN(Cc1ccccc1)C(=O)c1cccnc1SCCS(=O)(=O)c1ccccc1",
        "output": "893"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.CCOC(=O)c1cnn(-c2cccc(-c3cc(F)ccc3CCc3ccc(OC)cc3C)n2)c1C(F)(F)F.ClCCl.O>>CCOC(=O)c1cnn(-c2cccc(-c3cc(F)ccc3CCc3ccc(O)cc3C)n2)c1C(F)(F)F",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)CCCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1.CO.[Pd]>>CN(C)CCCN1CCN(c2ccc(N)cc2)CC1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C=CCCCOC[C@H](NC(=O)OC(C)(C)C)C(=O)OC.CCOC(C)=O.Cl.O.O.[Li+].[OH-]>>C=CCCCOC[C@H](NC(=O)OC(C)(C)C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN(C)C=O.CNCc1cc2ccccc2n1C.ClCCCl.O.O=C(O)/C=C/c1cnc2[nH]cnc2c1.On1nnc2ccccc21>>CN(Cc1cc2ccccc2n1C)C(=O)/C=C/c1cnc2[nH]cnc2c1",
        "output": "811"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)[C@@H]1CC[C@@H](C)C[C@H]1C(O)CCCc1ccccn1.ClCCl.O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1>>CC(C)[C@@H]1CC[C@@H](C)C[C@H]1C(=O)CCCc1ccccn1",
        "output": "87"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cc(N)ccc1F.O=C(Cl)c1ccc(F)c([N+](=O)[O-])c1>>Cc1cc(NC(=O)c2ccc(F)c([N+](=O)[O-])c2)ccc1F",
        "output": "11"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)OC(=O)Cl.CN(C)C=O.COc1cnc(-c2ccc(N3CCNCC3)cc2)c2[nH]cc(C(=O)C(=O)N3CCN(c4nnnn4-c4ccccn4)CC3)c12>>COc1cnc(-c2ccc(N3CCN(C(=O)OC(C)C)CC3)cc2)c2[nH]cc(C(=O)C(=O)N3CCN(c4nnnn4-c4ccccn4)CC3)c12",
        "output": "219"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1ccc(-c2nocc2C(=O)O)cc1.Cl.F[B-](F)(F)F.OC1(c2ccccc2Cl)CCNC1>>Cc1ccc(-c2nocc2C(=O)N2CCC(O)(c3ccccc3Cl)C2)cc1",
        "output": "975"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCc2c(C(=O)O)n[nH]c2C1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Fc1ccc(Cl)c(C2CCNCC2)c1.O.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCc2c(C(=O)N3CCC(c4cc(F)ccc4Cl)CC3)n[nH]c2C1",
        "output": "663"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1Cl.Oc1ccc2cn[nH]c2c1.[K+].[K+]>>O=[N+]([O-])c1ccc(Oc2ccc3cn[nH]c3c2)cc1Cl",
        "output": "564"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COc1ccc2c(c1)NC(=O)[C@@H](C)NC(=O)CNC(=O)CCCC=C2.[Pd]>>COc1ccc2c(c1)NC(=O)[C@@H](C)NC(=O)CNC(=O)CCCCC2",
        "output": "362"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)C[C@H](N)C(N)=O.O=C(O)c1ccc(C2CC2)c(OCC2CC2)n1>>CC(C)C[C@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(N)=O",
        "output": "738"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.Cc1nc(N2CC[C@H](N3CCC[C@@H]3C)C2)ccc1N.Cl.Cl.ClCCl.O=C(O)C1CCOCC1.On1nnc2ccccc21>>Cc1nc(N2CC[C@H](N3CCC[C@@H]3C)C2)ccc1NC(=O)C1CCOCC1",
        "output": "724"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "NCCN1CCOCC1.O=S1CCN(c2nc(Cl)nc3c(SCc4ccccc4)ncnc23)CC1>>O=S1CCN(c2nc(NCCN3CCOCC3)nc3c(SCc4ccccc4)ncnc23)CC1",
        "output": "544"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COc1ccc(Sc2ccc([N+](=O)[O-])cc2)cc1>>COc1ccc(Sc2ccc(N)cc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(OCc2ccccc2)C1.Cl>>c1ccc(COC2CCNC2)cc1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#CCN1CCOCC1.C1CCOC1.CCN(CC)CC.COC(=O)COc1ccc(OC/C=C(\\c2ccccc2)c2ccc(Br)cc2)cc1C.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COC(=O)COc1ccc(OC/C=C(\\c2ccccc2)c2ccc(C#CCN3CCOCC3)cc2)cc1C",
        "output": "659"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cl.Cl[Sn]Cl.Nc1cc(F)ccc1OCc1ccccc1.O.O=N[O-].[Na+]>>NNc1cc(F)ccc1OCc1ccccc1",
        "output": "109"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C[C@H]1CC(C#N)(Nc2cccc(F)c2)CCN1C(=O)OCc1ccccc1.N.O.[Ni]>>C[C@H]1CC(CN)(Nc2cccc(F)c2)CCN1C(=O)OCc1ccccc1",
        "output": "246"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1ccc(C#N)c(OCCc2ccc(Cl)cc2Cl)c1.Cl.O.O.[Li+].[OH-]>>N#Cc1ccc(C(=O)O)cc1OCCc1ccc(Cl)cc1Cl",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCBr.CCOC(C)=O.CN(C)C=O.O.O=C(c1ccc(-c2cccc(C(F)(F)F)c2)cc1)N1CC(N[C@H]2CCN(C(=O)c3ccccc3)C2)C1.[H-].[Na+]>>CCN(C1CN(C(=O)c2ccc(-c3cccc(C(F)(F)F)c3)cc2)C1)[C@H]1CCN(C(=O)c2ccccc2)C1",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.Cc1noc(-c2ccc(Br)cc2Cl)c1NC(=O)O[C@H](C)c1ccccc1Cl>>CCOC(=O)Cc1ccc(-c2ccc(-c3onc(C)c3NC(=O)O[C@H](C)c3ccccc3Cl)c(Cl)c2)cc1",
        "output": "933"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.ClI.Nc1c(F)cccc1F.O>>Nc1c(F)cc(I)cc1F",
        "output": "466"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1(C)CNc2cc([N+](=O)[O-])ccc21.CCN(CC)CC.ClCCl>>CC(C)(C)OC(=O)N1CC(C)(C)c2ccc([N+](=O)[O-])cc21",
        "output": "827"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCN(Cc1ccccc1)C(=O)Nc1ccc(C(=O)OCC)cc1.CCO.Cl.[Na+].[OH-]>>CCCCN(Cc1ccccc1)C(=O)Nc1ccc(C(=O)O)cc1",
        "output": "5"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.CSc1ccccc1CC[C@H](O)[C@H](C)OCc1ccccc1.ClCCl>>CSc1ccccc1CC[C@H](OS(C)(=O)=O)[C@H](C)OCc1ccccc1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1ccc2nc(-c3cc4cc(OC)ccc4n3C(=O)OC(C)(C)C)c(N(C)C(C)C)nc2c1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1ccc2nc(-c3cc4cc(OC)ccc4[nH]3)c(N(C)C(C)C)nc2c1",
        "output": "848"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(CCCN)c1ccccn1.CSc1ncc(Cc2ccc(Cl)c(Cl)c2)c(=O)[nH]1.c1ccncc1>>CN(CCCNc1ncc(Cc2ccc(Cl)c(Cl)c2)c(=O)[nH]1)c1ccccn1",
        "output": "101"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCc1cc(-c2ccc(Cc3ccccn3)cc2)no1.Fc1cccc(-c2nc3cn[nH]cc-3n2)c1F>>Fc1cccc(-c2nc3cnn(Cc4cc(-c5ccc(Cc6ccccn6)cc5)no4)cc-3n2)c1F",
        "output": "997"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)[C@@H](C)Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc4ccccn4)c3)c12.N>>C[C@@H](Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc4ccccn4)c3)c12)C(N)=O",
        "output": "432"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.CCOC(=O)CCc1c[nH]c2cc(-c3noc(-c4cnc(OC(C)C)c(C(F)(F)F)c4)n3)ccc12.Cl.O.[Na+].[OH-]>>CC(C)Oc1ncc(-c2nc(-c3ccc4c(CCC(=O)O)c[nH]c4c3)no2)cc1C(F)(F)F",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.COCCOc1ccc2ccc(C)nc2c1.O.O=[Se]=O>>COCCOc1ccc2ccc(C=O)nc2c1",
        "output": "619"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.CCOC(=O)CC(=O)CC.CCl.Cc1ccc(S(=O)(=O)O)cc1>>CCOC(=O)CC(=O)C(C)Br",
        "output": "82"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Nc1ccc(S(N)(=O)=O)c(F)c1.Cl.O.[Na+].[OH-]>>Nc1ccc(S(N)(=O)=O)c(F)c1",
        "output": "66"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.CCN(CC)CC.COc1cc(N2C[C@@H]3C[C@H]2CN3)ccc1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1.ClCCl>>COc1cc(N2C[C@@H]3C[C@H]2CN3C(C)=O)ccc1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCO.CCOC(=O)CC(=O)c1ccc2c(c1)OCO2.CCOC(=O)c1cn[nH]c1N.Cc1ccc(S(=O)(=O)O)cc1>>CCOC(=O)c1cnn2c(=O)cc(-c3ccc4c(c3)OCO4)[nH]c12",
        "output": "513"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC1(NC(=O)OCc2ccccc2)CCN(C(=O)OC(C)(C)C)CC1.CO.Cl>>CC1(NC(=O)OCc2ccccc2)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)Cc1ccccc1[N+](=O)[O-].[Pd]>>COC(=O)Cc1ccccc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cc1cnc2c([N+](=O)[O-])cccc2n1.[Cl-].[Cl-].[Cl-].[Ti+3]>>Cc1cnc2c(N)cccc2n1",
        "output": "269"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.CCOC(C)=O.C[C@H](N)c1nc2ccc(F)cc2n1-c1cccnc1.N#Cc1c(N)ncnc1Cl>>C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2n1-c1cccnc1",
        "output": "110"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C[C@H]1CCCNC1.O=C(O)[C@@H](O)c1ccccc1.O=C([O-])[O-].OCCCBr.[K+].[K+]>>C[C@H]1CCCN(CCCO)C1",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1ccc2c(cnn2C2CCCCO2)c1.C#CCCO.CCN(CC)CC.CCOC(C)=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>OCCC#Cc1ccc2c(cnn2C2CCCCO2)c1",
        "output": "659"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCI.O=C([O-])[O-].O=C([O-])[O-].OC1(c2cccc(Cl)c2F)CCNC1.[K+].[K+].[Na+].[Na+]>>CCN1CCC(O)(c2cccc(Cl)c2F)C1",
        "output": "184"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "II.O.O=C([O-])[O-].O=S(=O)([O-])O.Oc1ccnc(O)c1.[K+].[K+].[K+]>>Oc1ccnc(O)c1I",
        "output": "850"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN.CN(C)C=O.Cl.O.O=C([O-])[O-].O=[N+]([O-])c1cccc(-c2ccc3c(Br)cn(-c4cc(Cl)ncn4)c3c2)c1.[K+].[K+]>>CNc1cc(-n2cc(Br)c3ccc(-c4cccc([N+](=O)[O-])c4)cc32)ncn1",
        "output": "166"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)CBr.CN(C)C=O.Cc1c(O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F.O.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1C",
        "output": "123"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.CO.Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O.c1ccncc1>>CC(=O)OC[C@H]1O[C@@H](n2cc(C)c(=O)[nH]c2=O)C[C@@H]1N=[N+]=[N-]",
        "output": "254"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)NCCC(C)c1ccc(-c2ccc(F)cc2)cc1.[K+].[OH-]>>CC(CCN)c1ccc(-c2ccc(F)cc2)cc1",
        "output": "412"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)CCc1ccc(O)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCc1ccc(O)cc1",
        "output": "343"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)c1ccc2c(C3CCCCC3)c(Br)n(CC(=O)OC(C)(C)C)c2c1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1ccc2c(C3CCCCC3)c(Br)n(CC(=O)O)c2c1",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(S(=O)(=O)OCCCS(C)(=O)=O)cc1.O=Cc1cc(O)c(-c2ccc(F)cc2)c(C2CC2)c1>>CS(=O)(=O)CCCOc1cc(C=O)cc(C2CC2)c1-c1ccc(F)cc1",
        "output": "438"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C2Cc3cc(Cl)ncc3O2)CC1.NS(=O)(=O)c1ccc(B(O)O)cc1>>CC(C)(C)OC(=O)N1CCC(C2Cc3cc(-c4ccc(S(N)(=O)=O)cc4)ncc3O2)CC1",
        "output": "865"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CC1.O=Cc1ccc(O)c(Br)c1>>O=Cc1ccc(OCC2CC2)c(Br)c1",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.OCc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2.c1ccncc1>>CC(=O)OCc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2",
        "output": "254"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.CCCCCC.CCOC(C)=O.Cc1cc(O)c2cc(-c3cccc(C(F)(F)F)c3)nnc2c1.c1ccncc1>>CC(=O)Oc1cc(C)cc2nnc(-c3cccc(C(F)(F)F)c3)cc12",
        "output": "46"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.COC(=O)CCc1cn(-c2ccc(C(F)(F)F)nn2)nc1C(C)C.Cc1ccccc1.Cl.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[H-].[Na+].[Na+]>>CC(C)c1nn(-c2ccc(C(F)(F)F)nn2)cc1CCCO",
        "output": "343"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2cccc(-c3c(F)cc(C=O)cc3F)c2c1.O.[BH4-].[Na+]>>COC(=O)c1ccc2cccc(-c3c(F)cc(CO)cc3F)c2c1",
        "output": "356"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)CN1CCC(COc2ccc3c(c2)CN(C(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)CC3)CC1.CO.O.[BH4-].[Li+]>>CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)N1CCc2ccc(OCC3CCN(CCO)CC3)cc2C1",
        "output": "225"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.O=P([O-])([O-])[O-].OCCc1ccc(O)cc1.[H-].[Na+]>>CC(C)(C)[Si](C)(C)Oc1ccc(CCO)cc1",
        "output": "746"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1C(=O)CCC2(c3ccccc3)c3nc(-c4ccccc4)nc(Cl)c3CCC12.CO.C[O-].[Na+]>>COc1nc(-c2ccccc2)nc2c1CCC1C(C)C(=O)CCC21c1ccccc1",
        "output": "461"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(C#N)c(-c2ccc(Cl)s2)c(C#N)c1O.COc1cc(C#N)c(Br)c(C#N)c1O.OB(O)c1ccc(Cl)s1>>N#Cc1cc(O)c(O)c(C#N)c1-c1ccc(Cl)s1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)COC(=O)Cl.CCN(CC)CC.CN(C)C=O.Cc1ccc2c(N3CC[C@@H](CN)C3)nc(-c3ccccc3O)nc2c1.ClCCl>>Cc1ccc2c(N3CC[C@@H](CNC(=O)OCC(C)(C)C)C3)nc(-c3ccccc3O)nc2c1",
        "output": "94"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.Cl.N[C@@H](COCc1ccc(F)cc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1>>CC(=O)N[C@@H](COCc1ccc(F)cc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1",
        "output": "133"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2nc3cc(Br)ccc3o2)CC1.OB(O)c1ccc(C(F)(F)F)cc1>>CC(C)(C)OC(=O)N1CCC(c2nc3cc(-c4ccc(C(F)(F)F)cc4)ccc3o2)CC1",
        "output": "909"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=C(O)c1ncccc1Br.O=C([O-])O.O=S(=O)(O)O.[Na+]>>COC(=O)c1ncccc1Br",
        "output": "331"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Fc1ccc(-c2cc(C(F)(F)F)nc(Cl)n2)cc1F.OB(O)c1cccc(Br)c1>>Fc1ccc(-c2cc(C(F)(F)F)nc(-c3cccc(Br)c3)n2)cc1F",
        "output": "874"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.COC(=O)C1CCNC(Cc2cc(C(C)(C)C)cc(C(C)(C)C)c2)C1.COC(=O)Cl.ClCCl>>COC(=O)C1CCN(C(=O)OC)C(Cc2cc(C(C)(C)C)cc(C(C)(C)C)c2)C1",
        "output": "219"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C[AlH]CC(C)C.CCOC(=O)COc1ccc(-c2ccccc2)cc1.Cc1ccccc1>>OCCOc1ccc(-c2ccccc2)cc1",
        "output": "225"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=C(O)c1cc([N+](=O)[O-])c(Oc2ccccc2)c([N+](=O)[O-])c1.O=S(=O)(O)O>>COC(=O)c1cc([N+](=O)[O-])c(Oc2ccccc2)c([N+](=O)[O-])c1",
        "output": "33"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(CC(C)C(=O)O)cc1.O.O=C1CCc2ccccc21>>COc1ccc2c(c1)C(=O)C(C)C2",
        "output": "274"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)C(F)(F)c1cccc(CN2CCOCC2)c1.CO.O.O.[Li+].[OH-]>>O=C(O)C(F)(F)c1cccc(CN2CCOCC2)c1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)CCC(=O)Cl.ClCCl.Fc1ccc(-c2ccccc2)cc1.[Al+3].[Cl-].[Cl-].[Cl-]>>COC(=O)CCC(=O)c1ccc(-c2ccc(F)cc2)cc1",
        "output": "31"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Br.COc1cc2nc(Cl)nc(Cl)c2cc1OC.Cc1ccc2c(c1)c(=O)n(C1CCNCC1)c(=O)n2C>>COc1cc2nc(Cl)nc(N3CCC(n4c(=O)c5cc(C)ccc5n(C)c4=O)CC3)c2cc1OC",
        "output": "296"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.C[S-].O.O=[N+]([O-])c1ccc(Br)cc1F.[Na+]>>CSc1cc(Br)ccc1[N+](=O)[O-]",
        "output": "503"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCn1c(=O)n(Cc2ccccc2F)c(=O)c2[nH]c(Cc3ccc(N)cc3)nc21.O=S(=O)(Cl)c1ccc(F)c(Cl)c1>>CCCCn1c(=O)n(Cc2ccccc2F)c(=O)c2[nH]c(Cc3ccc(NS(=O)(=O)c4ccc(F)c(Cl)c4)cc3)nc21",
        "output": "68"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)c1cccc(NC(=O)c2nnn(Cc3ccc(Cl)c(Cl)c3)c2C)c1.[Na+].[OH-]>>Cc1c(C(=O)Nc2cccc(C(=O)O)c2)nnn1Cc1ccc(Cl)c(Cl)c1",
        "output": "5"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO.COC(=O)C1(SCc2ccc(OC)cc2)Cc2ccccc2C1.O.[K+].[OH-]>>COc1ccc(CSC2(C(=O)O)Cc3ccccc3C2)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCCl.Fc1cccc(CC2CN3CCC2CC3)c1.O.O=S(=O)(O)Cl>>O=S(=O)(Cl)c1ccc(F)cc1CC1CN2CCC1CC2",
        "output": "182"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.NS(=O)(=O)OC[C@H]1C=C[C@H](n2ccc3c(N[C@H]4CCc5ccccc54)ncnc32)C1.[Pd]>>NS(=O)(=O)OC[C@H]1CC[C@H](n2ccc3c(N[C@H]4CCc5ccccc54)ncnc32)C1",
        "output": "143"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(=O)NC[C@@H]1OC(=O)N2c3ccc(Br)cc3C[C@@H]12.Cn1nnnc1-c1ccc(B2OC(C)(C)C(C)(C)O2)cn1.O.O=C([O-])[O-].[K+].[K+]>>CC(=O)NC[C@@H]1OC(=O)N2c3ccc(-c4ccc(-c5nnnn5C)nc4)cc3C[C@@H]12",
        "output": "954"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Cl.O=Cc1c(Br)ccc(O)c1O.[BH4-].[Cl-].[NH4+].[Na+]>>OCc1c(Br)ccc(O)c1O",
        "output": "356"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)CC(C)(C)CCl.Cl.OC1CCCC2Oc3ccccc3OC12>>CN(C)CC(C)(C)COC1CCCC2Oc3ccccc3OC12",
        "output": "308"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCC12CCC(=O)C(C)=C1c1cc(F)c(OC)c(Cl)c1C2.Cl.c1ccncc1>>CCCCC12CCC(=O)C(C)=C1c1cc(F)c(O)c(Cl)c1C2",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(C)=O.Cc1ccccc1N1CCNCC1.O=C(Cl)CCl.O=C([O-])[O-].[Ca+2]>>Cc1ccccc1N1CCN(C(=O)CCl)CC1",
        "output": "125"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(COC2CCNCC2)n1-c1ccc(F)cc1.CCN(CC)CC.ClCCl.N#CBr>>CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(COC2CCN(C#N)CC2)n1-c1ccc(F)cc1",
        "output": "532"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCC[C@H](O)CC(=O)OC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CCCC[C@H](O)CCO",
        "output": "343"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.C[C@H](NC(=O)OC(C)(C)C)c1ccc(C(=O)O)c(Cl)c1.Cl.NC1CCCC1.O.On1nnc2cccnc21>>C[C@H](NC(=O)OC(C)(C)C)c1ccc(C(=O)NC2CCCC2)c(Cl)c1",
        "output": "821"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)C1CCc2c([nH]c3c(C(=O)O)cc(Br)cc23)C1.ClCCCl.ClCCl.O.On1nnc2ccccc21.[NH4+].[OH-]>>CCOC(=O)C1CCc2c([nH]c3c(C(N)=O)cc(Br)cc23)C1",
        "output": "704"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCCCC(=O)O.CN(C)c1ccncc1.Cc1cccc(C)c1O.ClCCCl>>Cc1cccc(C)c1OC(=O)CCCNC(=O)OC(C)(C)C",
        "output": "108"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=Cc1ccc2c(Cl)nc(Cl)cc2c1.[BH4-].[Na+]>>OCc1ccc2c(Cl)nc(Cl)cc2c1",
        "output": "356"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)CNc1cc(C)c(-c2nc3cc(C(=O)Nc4ccc(C)c(C)c4)ccc3[nH]2)c(C)c1.[Na+].[OH-]>>Cc1ccc(NC(=O)c2ccc3[nH]c(-c4c(C)cc(NCC(=O)O)cc4C)nc3c2)cc1C",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(C)=O.Nc1nc(-c2ccccc2)cs1.O=C(Cl)CCl>>O=C(CCl)Nc1nc(-c2ccccc2)cs1",
        "output": "553"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(=O)c1ccc(O)cc1O.CO.[H][H].[Ni].[Pd]>>CCc1ccc(O)cc1O",
        "output": "92"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)O.N[C@H]1CC[C@H](O)CC1.[Na+].[OH-]>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](O)CC1",
        "output": "631"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCO.Cc1cc(N)nc(S)n1.Clc1ccc(Cl)c(CBr)c1Cl>>Cc1cc(N)nc(SCc2c(Cl)ccc(Cl)c2Cl)n1",
        "output": "699"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cccc(N(C)C(=O)c2ccc(Br)s2)c1.Cc1cccc(B(O)O)c1F.[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cccc(N(C)C(=O)c2ccc(-c3cccc(C)c3F)s2)c1",
        "output": "864"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(=O)CCC1CC2(CCN1C(=O)OC(C)(C)C)OCCO2.CO.Cl>>CCOC(=O)CCC1CC2(CCN1)OCCO2",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(CC(=O)N[C@@H]1CCc2ccccc2NC1=O)NC(=O)OC(C)(C)C.N#Cc1ccccc1-c1ccc(CBr)c(Br)c1>>CC(C)(CC(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3C#N)cc2Br)C1=O)NC(=O)OC(C)(C)C",
        "output": "688"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.COc1ccc(N)cn1.Cl.ClCCl.O=C(O)c1ccc(Cl)c(I)c1.On1nnc2ccccc21>>COc1ccc(NC(=O)c2ccc(Cl)c(I)c2)cn1",
        "output": "759"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CN(Cc1ccc(C(F)(F)F)cc1)C1CN(Cc2ccccc2)CC1c1cccc(Cl)c1.O=C(Cl)OCC(Cl)(Cl)Cl>>CN(Cc1ccc(C(F)(F)F)cc1)C1CNCC1c1cccc(Cl)c1",
        "output": "84"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCN(CC)CC.CN(C)c1ccncc1.CN(c1cccc2cc(C3=NCC(CC(=O)O)S3)[nH]c12)S(=O)(=O)c1cccs1.CS(N)(=O)=O.Cc1cccc([N+](=O)[O-])c1C(=O)OC(=O)c1c(C)cccc1[N+](=O)[O-].Cl>>CN(c1cccc2cc(C3=NCC(CC(=O)NS(C)(=O)=O)S3)[nH]c12)S(=O)(=O)c1cccs1",
        "output": "644"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)CCN.Nc1ccc(C(=O)O)cc1.On1nnc2ccccc21.[Na+].[OH-]>>CN(C)CCNC(=O)c1ccc(N)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Nc1cc(O)ccc1CCCl.O=C(O)c1cc2cc([N+](=O)[O-])ccc2[nH]1>>O=C(Nc1cc(O)ccc1CCCl)c1cc2cc([N+](=O)[O-])ccc2[nH]1",
        "output": "548"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC(COc2ccccc2)C1.ClCCl.O=C(O)C(F)(F)F>>c1ccc(OCC2CNC2)cc1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)CCCc1nnc(-c2ccc(NC(=O)Nc3ccc(Cl)cc3Oc3ccccc3)cc2)s1.O=C(O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1>>O=C(O)CCCc1nnc(-c2ccc(NC(=O)Nc3ccc(Cl)cc3Oc3ccccc3)cc2)s1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "NC1CCN(CC(O)C2COc3ccccc3O2)CC1.O=C=NC1CCCCC1.[Na]>>O=C(NC1CCCCC1)NC1CCN(CC(O)C2COc3ccccc3O2)CC1",
        "output": "244"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(-c2cccc(C(=O)CC(=O)Nc3cc(C(F)(F)F)c(C)cc3NC(=O)OC(C)(C)C)c2)ccn1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(-c2cccc(C3=Nc4cc(C)c(C(F)(F)F)cc4NC(=O)C3)c2)ccn1",
        "output": "930"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Clc1ccc(-c2ccnc(Cl)c2-c2ccncc2)cc1.NN.O.c1ccncc1>>NNc1nccc(-c2ccc(Cl)cc2)c1-c1ccncc1",
        "output": "417"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CC(C)(C)c1cc(I)c(O)c(C=O)c1.CCO.Cl.NO.O.O.O.O.[Na+]>>CC(C)(C)c1cc(I)c(O)c(C=NO)c1",
        "output": "30"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)CCCCC(=O)c1cc(OC)ccc1OC.Cl.O.[Zn]>>COC(=O)CCCCCc1cc(OC)ccc1OC",
        "output": "92"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)Nc1sc(Br)cc1C(=O)N1CCC(N2CCCC3(C2)CC(C)(C)OC3=O)CC1.COC(=O)CCc1ccc(B(O)O)cc1>>COC(=O)CCc1ccc(-c2cc(C(=O)N3CCC(N4CCCC5(C4)CC(C)(C)OC5=O)CC3)c(NC(=O)OC(C)(C)C)s2)cc1",
        "output": "864"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O=[N+]([O-])c1ccc(F)cc1Nc1ncccn1.[Pd]>>Nc1ccc(F)cc1Nc1ncccn1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.N#Cc1ccccc1F.O.O=C([O-])[O-].Oc1cccnc1Cl.[K+].[K+]>>N#Cc1ccccc1Oc1cccnc1Cl",
        "output": "845"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Ic1ccccc1.c1cc[nH]c1>>c1ccc(-n2cccc2)cc1",
        "output": "267"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC[C@@H](C(=O)O)N(Cc1ccccc1)Cc1ccccc1.O=C(OCc1ccccc1)[C@H](CC1CCC1)N(Cc1ccccc1)Cc1ccccc1>>O=C(O)[C@H](CC1CCC1)N(Cc1ccccc1)Cc1ccccc1",
        "output": "186"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.O.O=C(c1ccccc1)c1ccc2c(c1)sc1c3ccccc3sc21.[Al+3].[BH4-].[Cl-].[Cl-].[Cl-].[Na+]>>c1ccc(Cc2ccc3c(c2)sc2c4ccccc4sc32)cc1",
        "output": "181"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc2c(OCCBr)cccc2n1.Cl.NS(=O)(=O)c1cc(CC2CCNCC2)ccc1Cl>>Cc1ccc2c(OCCN3CCC(Cc4ccc(Cl)c(S(N)(=O)=O)c4)CC3)cccc2n1",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=CC(=O)Cl.CCN(C(C)C)C(C)C.CO.NC(=O)c1ccc(-c2cccc(N)c2)c2cn[nH]c12.O=C(O)C(F)(F)F>>C=CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]ncc23)c1",
        "output": "10"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCBr.CN(C)C=O.O.[N-]=[N+]=[N-].[Na+]>>CC(C)(C)OC(=O)NCCN=[N+]=[N-]",
        "output": "622"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCNCC.ClP(Cl)(Cl)(Cl)Cl.O=C(O)Cc1cccc(Oc2ccccc2F)c1[N+](=O)[O-]>>CCN(CC)C(=O)Cc1cccc(Oc2ccccc2F)c1[N+](=O)[O-]",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Cc1ccc([N+](=O)[O-])cc1Oc1cccnc1.O=CO.[Pd]>>Cc1ccc(N)cc1Oc1cccnc1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(-c2cnc(Nc3cnc(C#N)cn3)cc2NC2CCN(C(=O)OC(C)(C)C)CC2)cc1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(-c2cnc(Nc3cnc(C#N)cn3)cc2NC2CCNCC2)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCC.CCO.CCOC(C)=O.CCOC(C)=O.Cc1ccccc1.Cl[Pd]Cl.O=C([O-])[O-].O=Cc1c[nH]c2cc(Cl)c(Br)cc12.OCc1ccc(B(O)O)cc1.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=Cc1c[nH]c2cc(Cl)c(-c3ccc(CO)cc3)cc12",
        "output": "837"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.ClCCl.O.O=C1CCCCCCCCCCCCCC1.[I-].[Li]CCCC>>C=C1CCCCCCCCCCCCCC1",
        "output": "601"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCCCCCC)CC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>CCCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCCCCCC)CC(=O)O",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)Cn1ncc2c1CCCC2N.O=C(Cl)OCc1ccccc1.O=C([O-])[O-].[Na+].[Na+]>>CCOC(=O)Cn1ncc2c1CCCC2NC(=O)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc(OC)c2c(=O)[nH]c(-c3ccc(OCCN(C(=O)OC(C)(C)C)C(C)C)c(-c4ccc(SC)cc4)n3)nc2c1.ClCCl.O=C(OO)c1cccc(Cl)c1>>COc1cc(OC)c2c(=O)[nH]c(-c3ccc(OCCN(C(=O)OC(C)(C)C)C(C)C)c(-c4ccc(S(C)=O)cc4)n3)nc2c1",
        "output": "500"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1cccnc1C.ClCCl.O=C(OO)c1cccc(Cl)c1>>COC(=O)c1ccc[n+]([O-])c1C",
        "output": "262"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCO[C@H]1CN(c2nc(-c3ncnn3C)c(C(=O)OC)s2)CC[C@H]1NC(=O)c1cc(Cl)c(C)[nH]1.CO.[Na+].[OH-]>>CCCO[C@@H]1CN(c2nc(-c3ncnn3C)c(C(=O)O)s2)CC[C@@H]1NC(=O)c1cc(Cl)c(C)[nH]1",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CCN(CC)CC.Nc1ccc(Br)cn1>>CC(=O)Nc1ccc(Br)cn1",
        "output": "368"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCc1ccc(NC(=S)NC(=O)OC)c(N)c1.O.O=CO>>CCCCc1ccc(NC(=S)NC(=O)OC)c(NC=O)c1",
        "output": "27"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(-c2ccc(F)cc2F)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1.O=C1CCc2c(-c3ccc(F)cc3F)cc(O)cc2N1c1c(Cl)cccc1Cl>>O=c1ccc2c(-c3ccc(F)cc3F)cc(O)cc2n1-c1c(Cl)cccc1Cl",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1ccccc1-c1cn(C2CCN(Cc3ccccc3)CC2)c(=O)[nH]1.CCO.[Na+].[OH-]>>Nc1ccccc1-c1cn(C2CCN(Cc3ccccc3)CC2)c(=O)[nH]1",
        "output": "66"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(c1ccc2c(n1)CC[C@H](C(=O)O)C2)C(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCCC1=O.Cc1cc([C@@H](C)N)c(F)cc1NS(C)(=O)=O.Cl.F[P-](F)(F)(F)(F)F>>Cc1cc([C@@H](C)NC(=O)[C@H]2CCc3nc(C(C)(C)C(F)(F)F)ccc3C2)c(F)cc1NS(C)(=O)=O",
        "output": "599"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.Cc1ccc(Nc2cc(N(C)C)nc(NC(=O)Cc3ccccc3)n2)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1ccc(Nc2cc(N(C)C)nc(NCCc3ccccc3)n2)cc1",
        "output": "112"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1C(=O)NN=C2COc3ccc(C4=CCN(C(=O)OC(C)(C)C)C(Cc5ccccc5)C4)cc3N21.CO.[Pd]>>CC1C(=O)NN=C2COc3ccc(C4CCN(C(=O)OC(C)(C)C)C(Cc5ccccc5)C4)cc3N21",
        "output": "806"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.COc1ccc(-c2ccc3ccc(N)nc3n2)cc1.O.O=C(O)c1ccc(C(F)(F)F)cc1>>COc1ccc(-c2ccc3ccc(NC(=O)c4ccc(C(F)(F)F)cc4)nc3n2)cc1",
        "output": "744"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.CCOCC.CS(=O)(=O)c1ccc(N)cc1.Cl.O=C(Cl)C1CCCC1>>CS(=O)(=O)c1ccc(NC(=O)C2CCCC2)cc1",
        "output": "9"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NNc1ccc(I)cc1.O=Cc1ccc(O)cc1O>>Oc1ccc(C=NNc2ccc(I)cc2)c(O)c1",
        "output": "167"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(Cn2cc(-c3nc(Nc4ncccn4)sc3Cl)cn2)cc1.O=C(O)C(F)(F)F.O=C([O-])[O-].[Na+].[Na+]>>Clc1sc(Nc2ncccn2)nc1-c1cn[nH]c1",
        "output": "940"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cl.Cl.FC(F)(F)c1ccc(CO[C@H]2CCNC[C@H]2C(c2ccccc2)c2ccccc2)cc1.O=C(O)Cc1c[nH]cn1>>O=C(Cc1c[nH]cn1)N1CC[C@H](OCc2ccc(C(F)(F)F)cc2)[C@H](C(c2ccccc2)c2ccccc2)C1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COC(=O)c1c[nH]cc1-c1ccccc1.ClCc1ccc2cc(OCc3ccccc3)ccc2c1.O.[H-].[Na+]>>COC(=O)c1cn(Cc2ccc3cc(OCc4ccccc4)ccc3c2)cc1-c1ccccc1",
        "output": "556"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc(Br)cn1.O.O.[Li+].[OH-]>>O=C(O)c1ccc(Br)cn1",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)CCn1ncc2cc(-c3noc(-c4ccc(OC(C)C)c(C(F)(F)F)c4)n3)ccc21.[Na+].[OH-]>>CC(C)Oc1ccc(-c2nc(-c3ccc4c(cnn4CCC(=O)O)c3)no2)cc1C(F)(F)F",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)C=O.COc1c(Cl)cc(Cl)cc1-c1csc(N)n1.Cc1ccccc1.O=C(O)Cn1cnc2ccccc21.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COc1c(Cl)cc(Cl)cc1-c1csc(NC(=O)Cn2cnc3ccccc32)n1",
        "output": "681"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)NCc1ccc(-c2c(-c3ccccc3)[nH]c3ncc(Br)cc23)o1.CO.[K+].[OH-]>>NCc1ccc(-c2c(-c3ccccc3)[nH]c3ncc(Br)cc23)o1",
        "output": "412"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCO.Cn1nnnc1-c1ccc(OCc2ccccc2)c(F)c1.O=CO.[Pd]>>Cn1nnnc1-c1ccc(O)c(F)c1",
        "output": "23"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CO.Nc1ccc(Cl)c(C(F)(F)F)c1.[BH3-]C#N.[Cl-].[Cl-].[Na+].[Zn+2]>>CC(C)Nc1ccc(Cl)c(C(F)(F)F)c1",
        "output": "469"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC1)C(=O)N(Cc1ccc([N+](=O)[O-])cc1)CN2c1ccccc1.CCOC(C)=O.[Pd]>>CC(C)(C)OC(=O)N1CCC2(CC1)C(=O)N(Cc1ccc(N)cc1)CN2c1ccccc1",
        "output": "507"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)CN1CC2(CCCC(CNc3cc(Br)c(Cl)cc3[N+](=O)[O-])C2)OC1=O.CN(C)C=O.N#C[Cu].O.[Cl-].[Na+]>>CC(C)(C)CN1CC2(CCCC(CNc3cc(C#N)c(Cl)cc3[N+](=O)[O-])C2)OC1=O",
        "output": "531"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(Cl)Cl.CCN=C=NCCC[N+](C)(C)C.CN(C)C=O.Cc1cc(-c2cc(-c3cccc(C(=O)O)c3)[nH]c(=O)n2)ccc1O.NCCCN1CCOCC1.On1nnc2ccccc21.[I-]>>Cc1cc(-c2cc(-c3cccc(C(=O)NCCCN4CCOCC4)c3)[nH]c(=O)n2)ccc1O",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.C1COCCO1.COC(=O)c1ncc(OCC(F)(F)C(F)F)cc1F.Cl.[Na+].[OH-]>>O=C(O)c1ncc(OCC(F)(F)C(F)F)cc1F",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCc1cccc2[nH]c(C(=O)OCC)cc(=O)c12.[Na+].[OH-]>>CCCCc1cccc2[nH]c(C(=O)O)cc(=O)c12",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)Nc2nc3ccc(OS(=O)(=O)c4ccc(F)cc4)cc3s2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(Nc1nc2ccc(OS(=O)(=O)c3ccc(F)cc3)cc2s1)C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2ccnnc2C)s1.O.O.[Li]O>>Cc1nnccc1-c1ccc(C(=O)O)s1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(=O)NC(Cc1cccc(C(=O)OC(C)(C)C)c1OC)B1OC2CC3CC(C3(C)C)C2(C)O1.O=C(O)C(F)(F)F>>CCC(=O)NC(Cc1cccc(C(=O)O)c1OC)B1OC2CC3CC(C3(C)C)C2(C)O1",
        "output": "752"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.Cc1cc(OCC2CCCCNC2)ccc1F.Cc1ccc(-n2nccn2)c(C(=O)O)c1.ClCCCl.On1nnc2ccccc21>>Cc1ccc(-n2nccn2)c(C(=O)N2CCCCC(COc3ccc(F)c(C)c3)C2)c1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC1CCc2c(Cl)ncnc21.CC(C)(C)OC(=O)N1CCNCC1.CCOC(C)=O.CN1CCCC1=O>>CC(=O)OC1CCc2c1ncnc2N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "162"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)N1CCNCC1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)[O-].CCOC(C)=O.Cc1cc(Br)cc([N+](=O)[O-])c1N.Cc1ccccc1.[Na+].[Pd+2]>>CC(=O)N1CCN(c2cc(C)c(N)c([N+](=O)[O-])c2)CC1",
        "output": "294"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)CCOCCOCCOCCOCC=CCBr.ClCCl.O=C(O)C(F)(F)F>>O=C(O)CCOCCOCCOCCOCC=CCBr",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCc1cc(-c2ccc(C(F)(F)F)cn2)cc(F)n1>>CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cc(-c2ccc(C(F)(F)F)cn2)cc(F)n1",
        "output": "216"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1cc(-c2cc(C(=O)O)ccn2)c(C)[nH]c1=O.NCCc1ccc([N+](=O)[O-])cc1>>CCc1cc(-c2cc(C(=O)NCCc3ccc([N+](=O)[O-])cc3)ccn2)c(C)[nH]c1=O",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1cccc2c(C3=C(c4nc(N5CCN(C(=O)OC(C)(C)C)C6(CC6)C5)cc5ccccc45)C(=O)N(CO)C3=O)c[nH]c12.ClCCCl.O=C(O)C(F)(F)F>>Cc1cccc2c(C3=C(c4nc(N5CCNC6(CC6)C5)cc5ccccc45)C(=O)N(CO)C3=O)c[nH]c12",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=C(CO[Si](C)(C)C(C)(C)C)C(=O)O.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCOC(=O)c1c[nH]c2ncnc(-c3cccc(N)c3)c12>>C=C(CO[Si](C)(C)C(C)(C)C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1",
        "output": "170"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)[C@H](C)O[Si](C)(C)C(C)(C)C.[Li+].[OH-]>>C[C@H](O[Si](C)(C)C(C)(C)C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc2nccc(Cl)c2cc1OC.CS(C)=O.Cl.Nc1ccc(O)cc1Cl.O.[H-].[Na+]>>COc1cc2nccc(Oc3ccc(N)c(Cl)c3)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)COc1c(Br)cc(-c2cccc3sc4ccccc4c23)cc1Br.CO.[K+].[OH-]>>O=C(O)COc1c(Br)cc(-c2cccc3sc4ccccc4c23)cc1Br",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)CC1CCN(C(=O)CC2OC(C(=O)c3cccc(Cl)c3Cl)c3cc(Cl)ccc3-n3cccc32)CC1.CO.ClC(Cl)Cl.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])[O-].[K+].[K+]>>O=C(O)CC1CCN(C(=O)CC2OC(C(=O)c3cccc(Cl)c3Cl)c3cc(Cl)ccc3-n3cccc32)CC1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1ccc2[nH]cc(C(C)=O)c2c1.OCCO.[K+].[OH-]>>CC(=O)c1c[nH]c2ccc(C(=O)O)cc12",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCn1c(-c2cccc(OC)c2)nc2cc(C3=NN(CCOC4CCCCO4)C(=O)SC3)ccc21.CO.Cl.O=C([O-])O.[Na+]>>CCn1c(-c2cccc(OC)c2)nc2cc(C3=NN(CCO)C(=O)SC3)ccc21",
        "output": "543"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cl.O=[N+]([O-])c1cc(NS(=O)(=O)c2ccccc2)ccc1Br.[Fe]>>Nc1cc(NS(=O)(=O)c2ccccc2)ccc1Br",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cc2c([nH]1)C(CCCc1ccccc1)CC2.[Na+].[OH-]>>O=C(O)c1cc2c([nH]1)C(CCCc1ccccc1)CC2",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCC(C)Oc1ccc(OCC(O)CO)cc1.Cc1ccc(S(=O)(=O)O)cc1.O>>CCC(C)Oc1ccc(OCC2COC(C)(C)O2)cc1",
        "output": "265"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(O)C(=O)O.COc1cc(O[C@H]2CCNC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1>>COc1cc(O[C@H]2CCN(C(=O)C(C)O)C2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1ccc(O)cc1.CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)[C@H](CO)C1.CCOC(=O)/N=N/C(=O)OCC.Cc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(=O)c1ccc(OC[C@@H]2CN(C(=O)OC(C)(C)C)CCN2Cc2ccccc2)cc1",
        "output": "550"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.Cc1c(NC(=O)c2ccc(F)cc2)cccc1-c1ccc(C(N)=O)c2[nH]c3cc(C(=O)O)ccc3c12.ClCCCl.On1nnc2cccnc21.[NH4+].[OH-]>>Cc1c(NC(=O)c2ccc(F)cc2)cccc1-c1ccc(C(N)=O)c2[nH]c3cc(C(N)=O)ccc3c12",
        "output": "358"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.Cc1ccccc1C(=O)c1ccc(N(C(=O)OC(C)OC(=O)CCC(=O)OCc2ccccc2)c2ccc(F)cc2C)cc1Cl.[Pd]>>Cc1ccccc1C(=O)c1ccc(N(C(=O)OC(C)OC(=O)CCC(=O)O)c2ccc(F)cc2C)cc1Cl",
        "output": "186"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CNC1.CCOC(C)=O.CN(C)C=O.Cc1ccc(C(O)(c2ccc3nc(Cl)c(Cc4ccc(-n5cccn5)cc4)c(Cl)c3c2)c2cnnn2C)c(C)n1>>Cc1ccc(C(O)(c2ccc3nc(N4CCC4)c(Cc4ccc(-n5cccn5)cc4)c(Cl)c3c2)c2cnnn2C)c(C)n1",
        "output": "220"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.O=C(O)c1ccc(C2CC2)c(OCC2CC2)n1.OC(C1CCNC1)C(F)(F)F>>O=C(c1ccc(C2CC2)c(OCC2CC2)n1)N1CCC(C(O)C(F)(F)F)C1",
        "output": "605"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.O=[N+]([O-])c1cc2ccccc2[nH]1.[Cl-].[Fe].[NH-]C(=O)C=O.[NH4+]>>Nc1cc2ccccc2[nH]1",
        "output": "457"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C1(c2cc(O)cc(F)c2)CCOCC1.CCOC(C)=O.CN(C)C=O.Cc1ccccc1.Cc1nccn1-c1ccc(CCl)cc1.Cl.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C1(c2cc(F)cc(OCc3ccc(-n4ccnc4C)cc3)c2)CCOCC1",
        "output": "49"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)COc1cccc(N)c1.O=C(O)c1ccc(Br)o1>>CCOC(=O)COc1cccc(NC(=O)c2ccc(Br)o2)c1",
        "output": "860"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CN.Cc1ccc(CO)nc1Cl>>CNc1nc(CO)ccc1C",
        "output": "70"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccc(-c2c(C)cccc2C(=O)Nc2ccc(OCCc3cccc(NC(=O)OC(C)(C)C)n3)cc2)cc1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(-c2c(C)cccc2C(=O)Nc2ccc(OCCc3cccc(N)n3)cc2)cc1",
        "output": "885"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cccc(-c2ncccc2-c2ccc3ncc(C(=O)O)n3c2)n1.F[P-](F)(F)(F)(F)F.NCC(F)F>>Cc1cccc(-c2ncccc2-c2ccc3ncc(C(=O)NCC(F)F)n3c2)n1",
        "output": "697"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.COC(=O)c1ccc(CCc2cccc3c2NCC3)cc1.COc1cc(OC)cc(C(=O)Cl)c1.Cl.ClCCl>>COC(=O)c1ccc(CCc2cccc3c2N(C(=O)c2cc(OC)cc(OC)c2)CC3)cc1",
        "output": "614"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C1(NC(=O)c2cccc(C)c2OC(C)C)Cc2ccc(C(F)(F)F)cc2C1.O.[K+].[OH-]>>Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(C(F)(F)F)cc3C2)c1OC(C)C",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=C(O)c1ccc(C(F)(F)F)cc1Br.O=S(=O)(O)O>>CCOC(=O)c1ccc(C(F)(F)F)cc1Br",
        "output": "33"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.Cc1ccc(N)c(O)c1.O=C(Cl)CCl>>Cc1ccc(NC(=O)CCl)c(O)c1",
        "output": "9"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.Clc1ncc(Br)cn1.[H-].[Na+]>>CC(C)Oc1ncc(Br)cn1",
        "output": "37"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Cc1cc([N+](=O)[O-])ccc1Oc1cccc(C=CC(C)C)c1.O.[Ca+2].[Cl-].[Cl-]>>Cc1cc(N)ccc1Oc1cccc(C=CC(C)C)c1",
        "output": "335"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)n1c(-c2ccc(N)c3c2C(=O)NC3=O)cc2ccccc21.CO.CO.Cl.O=C([O-])O.[Na+]>>Nc1ccc(-c2cc3ccccc3[nH]2)c2c1C(=O)NC2=O",
        "output": "848"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.Fc1c(Br)ccc2nc(Cl)ncc12.Nc1ccc(N2CCOCC2)cc1>>Fc1c(Br)ccc2nc(Nc3ccc(N4CCOCC4)cc3)ncc12",
        "output": "808"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCCCBr.CN1CCCC1=O.O=C([O-])[O-].Oc1cccc2[nH]ccc12.[K+].[K+]>>BrCCCCCOc1cccc2[nH]ccc12",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CN(C)C=O.CNO.Cl.O=C(Cl)C(=O)Cl.O=C(O)C1CCC(C2CCCCC2)CC1.[Na+].[OH-]>>CN(O)C(=O)C1CCC(C2CCCCC2)CC1",
        "output": "54"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1.O=C(CCO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1ccc(=O)n(C(=O)c2ccccc2)c1=O)OCC(F)(F)F.c1ccncc1>>COc1ccc(C(OC[C@H]2O[C@@H](n3ccc(=O)n(C(=O)c4ccccc4)c3=O)[C@H](OCCC(=O)OCC(F)(F)F)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1",
        "output": "250"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.Cl.FC1(F)CCNC1.F[P-](F)(F)(F)(F)F.O.O=C(O)c1ccc(B(O)O)cc1F>>O=C(c1ccc(B(O)O)cc1F)N1CCC(F)(F)C1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.ClCCN1CCCC1.O=C([O-])[O-].O=[N+]([O-])c1ccc2c(Br)n[nH]c2c1.[K+].[K+]>>O=[N+]([O-])c1ccc2c(Br)nn(CCN3CCCC3)c2c1",
        "output": "604"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Cc1cc(Oc2ncccc2[N+](=O)[O-])n(-c2ccccc2Cl)n1.O.[Cl-].[Fe].[NH4+]>>Cc1cc(Oc2ncccc2N)n(-c2ccccc2Cl)n1",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.Clc1cccnc1Cl.O=S(=O)(c1ccc(Nc2ncnc3c2CNCC3)cc1)C(F)(F)F>>O=S(=O)(c1ccc(Nc2ncnc3c2CN(c2ncccc2Cl)CC3)cc1)C(F)(F)F",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccccc1.Cl.Nc1ccccc1.O=C(O)c1ccccc1Cl.O=S(Cl)Cl>>O=C(Nc1ccccc1)c1ccccc1Cl",
        "output": "50"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CCc1noc(-c2ccc(F)c(F)c2)n1)C(=O)OC(C)(C)C.ClC(Cl)Cl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CCNCCc1noc(-c2ccc(F)c(F)c2)n1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCC1(CC)CS(=O)(=O)c2ccc(N(C)C)cc2C(c2cccc(NC(=O)COCCOCCOCC(=O)O)c2)C1O.CO.ClCCl.NCc1ccc(C2C(CCC(O)c3ccccc3)C(=O)N2c2ccc(F)cc2)cc1>>CCCCC1(CC)CS(=O)(=O)c2ccc(N(C)C)cc2C(c2cccc(NC(=O)COCCOCCOCC(=O)NCc3ccc(C4C(CCC(O)c5ccccc5)C(=O)N4c4ccc(F)cc4)cc3)c2)C1O",
        "output": "599"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(O)C1Cc2ccccc2N(Cc2ccccc2)C1.CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.O=S(=O)([O-])O.[K+]>>CC(=O)C1Cc2ccccc2N(Cc2ccccc2)C1",
        "output": "87"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O.CCN=C=NCCCN(C)C.CNOC.ClCCl.O.On1nnc2ccccc21>>CON(C)C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C",
        "output": "54"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCN(CC)CC.CCOC(=O)[C@H](N)CCSC.Cl.ClCCl.Cn1cc(C[C@@H](NC(=O)OC(C)(C)C)C(=O)O)c2ccccc21>>CCOC(=O)[C@@H](CCSC)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)OC(C)(C)C",
        "output": "107"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCN1.CC(C)(C)[O-].CCOC(C)=O.Cc1ccccc1.Cc1oc(-c2ccc(Br)cc2)nc1CCOc1ccc(CCC(=O)OC(C)(C)C)c(COC(=O)NC2CCCCC2)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1oc(-c2ccc(N3CCOCC3)cc2)nc1CCOc1ccc(CCC(=O)OC(C)(C)C)c(COC(=O)NC2CCCCC2)c1",
        "output": "294"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(C(C)C)C(C)C.Cc1ccc(-c2cc(CCC=O)nn2C(C)(C)C)cc1.Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1.[Na+]>>Cc1ccc(-c2cc(CCCN3CCN(C(c4ccc(F)cc4)c4ccc(F)cc4)CC3)nn2C(C)(C)C)cc1",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CNC1.CC(=O)N1CCC2(C1)CN(C(=O)Nc1ncc(Cl)s1)c1ccc(/C=C/C(=O)O)cc12.Cl>>CC(=O)N1CCC2(C1)CN(C(=O)Nc1ncc(Cl)s1)c1ccc(/C=C/C(=O)N3CCC3)cc12",
        "output": "811"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(F)cc(OC2CCN(CC(CC#N)n3cc(-c4ncnc5c4ccn5COCC[Si](C)(C)C)cn3)CC2)c1.Cl.O.O.[Li+].[OH-]>>C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C(CC#N)CN4CCC(Oc5cc(F)cc(C(=O)O)c5)CC4)c3)ncnc21",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OCc1ccc(C(F)(F)F)cc1[N+](=O)[O-].CO.O=P([O-])([O-])[O-].[Na+].[Na+].[Na+].[Na+].[OH-]>>O=[N+]([O-])c1cc(C(F)(F)F)ccc1CO",
        "output": "497"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C(=O)C3CCN(C(=O)OC(C)(C)C)CC3)n(C)c2n1.ClCCl.O=C(O)C(F)(F)F>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C(=O)C3CCNCC3)n(C)c2n1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Brc1cnc(C2=CCOCC2)nc1.C1COCCO1.COC(=O)c1cc(F)c(NS(=O)(=O)c2ccc(B(O)O)cc2)cc1F.Cl[Pd]Cl.O.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COC(=O)c1cc(F)c(NS(=O)(=O)c2ccc(-c3cnc(C4=CCOCC4)nc3)cc2)cc1F",
        "output": "871"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CC[N-]CC.CN(C)CCN(C)C.COc1cccc(OC)c1.O.O=C=O.[K+]>>COc1cccc(OC)c1C(=O)O",
        "output": "387"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.C[C@@H](O)CO.ClCCl.c1c[nH]cn1>>C[C@@H](O)CO[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N(Cc1ccc(C(=O)O)cc1)c1ccc(C2CCCCC2)cc1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)[C@H](O)CN.O.On1nnc2ccccc21>>COC(=O)[C@H](O)CNC(=O)c1ccc(CN(C(=O)OC(C)(C)C)c2ccc(C3CCCCC3)cc2)cc1",
        "output": "821"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COC(=O)CC(NC(=O)[C@@H]1CCCN(C(=O)CCC2CCN(C(=O)OC(C)(C)C)CC2)C1)c1cncc(-c2ccc(O)cc2)c1.Cc1ccc(S(=O)(=O)OCCOS(=O)(=O)c2ccc(C)cc2)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)CC(NC(=O)[C@@H]1CCCN(C(=O)CCC2CCN(C(=O)OC(C)(C)C)CC2)C1)c1cncc(-c2ccc(OCCOS(=O)(=O)c3ccc(C)cc3)cc2)c1",
        "output": "438"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)c1ccc(-n2cnc3ccccc32)cc1NC(=O)c1ccccc1.O=C(O)C(F)(F)F>>O=C(Nc1cc(-n2cnc3ccccc32)ccc1C(=O)O)c1ccccc1",
        "output": "752"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.O=C1C2=C(CCCC2)C(=O)N1c1cc([N+](=O)[O-])ccc1F.O=[Pt]=O.[H][H]>>Nc1ccc(F)c(N2C(=O)C3=C(CCCC3)C2=O)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.O=C(N[C@H]1Cc2ccc(CO)cc2C1)OCc1ccccc1.O=S(Cl)Cl>>O=C(N[C@H]1Cc2ccc(CCl)cc2C1)OCc1ccccc1",
        "output": "81"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)NC(C)C.O=C(Cl)Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1.c1ccc2c(c1)ncn2C1CCNCC1>>O=C(Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1)N1CCC(n2cnc3ccccc32)CC1",
        "output": "219"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OC(c1ccccc1)c1ccc2nccnc2c1>>CS(=O)(=O)OC(c1ccccc1)c1ccc2nccnc2c1",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(Cl)Cl.CN(C)C=O.COC(=O)c1ccc[nH]1.ClCCCl.O=P(Cl)(Cl)Cl>>COC(=O)c1ccc(C=O)[nH]1",
        "output": "641"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.CSc1ccccc1.O=C(NNS(=O)(=O)NC(=O)N1C[C@H](NC(=O)OCc2ccccc2)C1=O)Nc1ccc(O)c(O)c1.O=C(O)C(F)(F)F>>N[C@H]1CN(C(=O)NS(=O)(=O)NNC(=O)Nc2ccc(O)c(O)c2)C1=O",
        "output": "128"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCCCCCCCCCCCCCN(C)CC(O)COC(c1ccccc1)(c1ccccc1)c1ccccc1.CCOCC.CS(=O)(=O)Cl.ClCCl.O>>CCCCCCCCCCCCCCCCCCN(C)CC(COC(c1ccccc1)(c1ccccc1)c1ccccc1)OS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "NNc1ncc(-c2ccc(OCc3ccccc3)cc2)nn1.NNc1ncc(-c2ccccc2)nn1.O=C(O)Cc1c[nH]c2ccccc12.O=C(O)Cc1ccc2ncccc2c1>>O=C(Cc1c[nH]c2ccccc12)NNc1ncc(-c2ccc(OCc3ccccc3)cc2)nn1",
        "output": "459"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN(C)CCN.ClCCl.N#Cc1ccc(Oc2cc(Cl)cc(Cl)c2)c(S(=O)(=O)Cl)c1>>CN(C)CCNS(=O)(=O)c1cc(C#N)ccc1Oc1cc(Cl)cc(Cl)c1",
        "output": "43"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cccc(-c2ccc(Oc3ccccc3)cc2)c1.O=C(O)c1cc2cccc(OC(F)(F)F)c2oc1=O>>O=C(Nc1cccc(-c2ccc(Oc3ccccc3)cc2)c1)c1cc2cccc(OC(F)(F)F)c2oc1=O",
        "output": "799"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.CCOC(=O)c1cc(C)[nH]c(=O)c1O.CN(C)C=O.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)c1cc(C)[nH]c(=O)c1OCc1ccccc1",
        "output": "623"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#CCBr.CCCC[N+](CCCC)(CCCC)CCCC.CCOCC.O.Oc1cccc2ccccc12.[Br-].[Na+].[OH-]>>C#CCOc1cccc2ccccc12",
        "output": "154"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)OB(c2ccc(-c3cnc(N)cn3)c(F)c2)OC1(C)C.NC(=O)C1(S(=O)(=O)c2ccccc2Br)CCCC1>>NC(=O)C1(S(=O)(=O)c2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)CCCC1",
        "output": "933"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCc1oc(-c2ccccc2)nc1COc1ccc(COc2cccc(CC(=O)OC)c2)cc1.CCO.Cl.O.[Na+].[OH-]>>CCCc1oc(-c2ccccc2)nc1COc1ccc(COc2cccc(CC(=O)O)c2)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1[nH]c(=S)n2c1CN=C(c1ccccc1Cl)c1cc(Cl)ccc1-2.[K+].[OH-]>>O=C(O)c1[nH]c(=S)n2c1CN=C(c1ccccc1Cl)c1cc(Cl)ccc1-2",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.O=C([O-])O.O=C1NC(=O)C(=Cc2cnn3c(NC4CCNCC4)cc(Nc4cccc(Cl)c4)nc23)N1.[Na+].[Na+]>>CC(C)N1CCC(Nc2cc(Nc3cccc(Cl)c3)nc3c(C=C4NC(=O)NC4=O)cnn23)CC1",
        "output": "187"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCC(Oc1cccc(-c2noc(C)n2)c1)C(=O)Cl.CN(C)c1ccncc1.ClCCl.Nc1ccc(N2CCOCC2)cc1>>CCCC(Oc1cccc(-c2noc(C)n2)c1)C(=O)Nc1ccc(N2CCOCC2)cc1",
        "output": "9"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CC(C(=O)O)C2)nc1CC.NS(=O)(=O)Cc1ccc(F)cc1Cl>>CCOC(=O)c1cc(C#N)c(N2CC(C(=O)NS(=O)(=O)Cc3ccc(F)cc3Cl)C2)nc1CC",
        "output": "644"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCOC(=O)c1cc2c(N3CCN(C(=O)OC(C)(C)C)CC3)cccc2s1.CCOC(C)=O.O.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCN(c2cccc3sc(C(=O)O)cc23)CC1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.COc1ccc(Cc2ccc(C=O)cc2O[C@@H]2O[C@H]([C@@H](C)OC(=O)c3ccccc3)[C@@H](OC(=O)c3ccccc3)[C@H](OC(=O)c3ccccc3)[C@H]2OC(=O)c2ccccc2)cc1.C[Mg]Br.[Cl-].[NH4+]>>COc1ccc(Cc2ccc(C(C)O)cc2O[C@@H]2O[C@H]([C@@H](C)OC(=O)c3ccccc3)[C@@H](OC(=O)c3ccccc3)[C@H](OC(=O)c3ccccc3)[C@H]2OC(=O)c2ccccc2)cc1",
        "output": "787"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCBr.ClC(Cl)Cl.O=C([O-])O.O=C1OC2(CCNCC2)c2ccccc21.[Na+]>>C=CCN1CCC2(CC1)OC(=O)c1ccccc12",
        "output": "252"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccccc1.CC(=O)c1ccc(F)cc1O.CCOC(C)=O.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1ccc(F)cc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)CC(C)c1cccc(C(F)(F)F)c1.CCOC(C)=O.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC(CCO)c1cccc(C(F)(F)F)c1",
        "output": "225"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.C[C@H](N)c1ccc(F)cc1.N#Cc1cc(F)cc(Nc2cc(C3CC3)[nH]n2)c1[N+](=O)[O-]>>C[C@H](Nc1cc(C#N)c([N+](=O)[O-])c(Nc2cc(C3CC3)[nH]n2)c1)c1ccc(F)cc1",
        "output": "764"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOCCOc1ccccc1COc1ccc2c(c1)C=C(C(=O)OC)CCS2(=O)=O.CO.O=C([O-])[O-].[K+].[K+]>>CCOCCOc1ccccc1COc1ccc2c(c1)C=C(C(=O)O)CCS2(=O)=O",
        "output": "58"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1cc(C(F)(F)F)cc2[nH]c(=O)[nH]c12.O=C(O)c1cc(F)c(F)c(F)c1>>O=C(Nc1cc(C(F)(F)F)cc2[nH]c(=O)[nH]c12)c1cc(F)c(F)c(F)c1",
        "output": "759"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COc1cnc([N+](=O)[O-])c(NC(=O)CCl)c1.O.[Cl-].[Fe].[NH4+]>>COc1cnc(N)c(NC(=O)CCl)c1",
        "output": "457"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Cl.CC(C)=O.COC(=O)NC(=S)Nc1ccc(N)cc1NC(=S)NC(=O)OC.O.O=C([O-])O.[Na+]>>COC(=O)NC(=S)Nc1ccc(NC(C)=O)cc1NC(=S)NC(=O)OC",
        "output": "9"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc2c(c1)nc(C)n2[C@@H]1CC[C@H](N)C1.Cl.O=C[C@H]1Cc2ccc(Br)cc2C1>>Cc1ccc2c(c1)nc(C)n2[C@@H]1CC[C@H](NC[C@H]2Cc3ccc(Br)cc3C2)C1",
        "output": "426"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CO.COc1ccc(Cn2nc(C)c3cc([N+](=O)[O-])ccc32)cc1.[Pd]>>COc1ccc(Cn2nc(C)c3cc(N)ccc32)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.Fc1ccc(CBr)cc1.Fc1ccc(CCOc2ccc3[nH]ccc3c2)cc1.[H-].[Na+]>>Fc1ccc(CCOc2ccc3c(ccn3Cc3ccc(F)cc3)c2)cc1",
        "output": "528"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.C[Si](C)(C)CN.Cl.ClCCl.O.O=C(O)c1ccc(F)c(Br)c1>>C[Si](C)(C)CNC(=O)c1ccc(F)c(Br)c1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(Br)cc1OCC2.C[Sn](C)(C)c1cnc[nH]1.Cc1nc([Sn](C)(C)C)cn1COCC[Si](C)(C)C>>CC(C)n1ncnc1-c1cn2c(n1)-c1ccccc1OCC2",
        "output": "350"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cc(C2(C(F)(F)F)CC(c3ccc(S(C)=O)cc3)=NO2)ccc1NC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>Cc1cc(C2(C(F)(F)F)CC(c3ccc(S(C)=O)cc3)=NO2)ccc1N",
        "output": "782"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1nc2n(c(=O)c1OCc1ccccc1)CCC2(C)C.CO.O.[Li+].[OH-]>>CC1(C)CCn2c1nc(C(=O)O)c(OCc1ccccc1)c2=O",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(Oc1ncn(-c2ccc(C(F)(F)F)cc2)n1)C(=O)O.NC1CC1>>CC(Oc1ncn(-c2ccc(C(F)(F)F)cc2)n1)C(=O)NC1CC1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cl.NO.O.O=C1C[C@@H]2CC=CC[C@@H]2C1.[Na+].[OH-]>>ON=C1C[C@@H]2CC=CC[C@@H]2C1",
        "output": "86"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1cccc(-c2[nH]nc(C(=O)N3CCC(N(CC)CC)C3)c2C)c1.Clc1ccc(I)cc1Cl>>CCN(CC)C1CCN(C(=O)c2n[nH]c(-c3cccc(C#Cc4ccc(Cl)c(Cl)c4)c3)c2C)C1",
        "output": "664"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO.CCOC(=O)/C=C/c1c(C#N)c2c(C)cc(C)nc2n1C1CCc2ccccc21.Cl.O.[Na+].[OH-]>>Cc1cc(C)c2c(C#N)c(/C=C/C(=O)O)n(C3CCc4ccccc43)c2n1",
        "output": "122"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(CC(=O)Cl)CC(C)(C)C.[Al+3].[Cl-].[Cl-].[Cl-].c1ccccc1>>CC(CC(=O)c1ccccc1)CC(C)(C)C",
        "output": "31"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl.OCCOCCn1ccnc1-c1ccccc1>>O=C(Cc1ccccc1Nc1c(Cl)cccc1Cl)OCCOCCn1ccnc1-c1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.COCCCOc1cc(C(O)CC(C)C)ccc1OC.O.[Cr+6].[O-2].[O-2].[O-2]>>COCCCOc1cc(C(=O)CC(C)C)ccc1OC",
        "output": "32"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C(=O)c1ccc(O[Si](C(C)C)(C(C)C)C(C)C)c(F)c1)N1CCC(O)(c2ccc(F)cc2)CC1.CCO.[BH4-].[Na+]>>CC(C(O)c1ccc(O[Si](C(C)C)(C(C)C)C(C)C)c(F)c1)N1CCC(O)(c2ccc(F)cc2)CC1",
        "output": "24"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C[Mg]Br.O=C1CCN(Cc2ccccc2)CC1>>CC1(O)CCN(Cc2ccccc2)CC1",
        "output": "514"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)Cc1ccc(OC)c(Oc2ccc(Br)cc2CSC(C)C)c1.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>CCOC(=O)Cc1ccc(OC)c(Oc2ccc(-c3cnn(C)c3)cc2CSC(C)C)c1",
        "output": "971"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCCCc1cc(OC2CCN(CCCNC(=O)OC(C)(C)C)CC2)c2ncccc2c1.Cl>>CCCCc1cc(OC2CCN(CCCN)CC2)c2ncccc2c1",
        "output": "538"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C(=O)O)CCC(N2C(=O)c3ccccc3C2=O)CC1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl>>CC1(C(=O)Cl)CCC(N2C(=O)c3ccccc3C2=O)CC1",
        "output": "56"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrC1CCC1.CN(C)C=O.COc1ccc(C#N)c(O)c1OC.O=C([O-])[O-].[K+].[K+]>>COc1ccc(C#N)c(OC2CCC2)c1OC",
        "output": "153"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1CN(C(=O)OCc2ccccc2)C12CCCN(C(=O)OC(C)(C)C)C2.ClC(Cl)Cl.O=C(O)C(F)(F)F.[Na+].[OH-]>>CC1CN(C(=O)OCc2ccccc2)C12CCCNC2",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=C1CC[C@H]2[C@H](CN)[C@@H]([C@@]3(C)CC[C@H](O)C[C@@H]3CO)CC[C@]12C.CO.O=Cc1ccc([N+](=O)[O-])cc1.[BH4-].[Na+]>>C=C1CC[C@H]2[C@H](CNCc3ccc([N+](=O)[O-])cc3)[C@@H]([C@@]3(C)CC[C@H](O)C[C@@H]3CO)CC[C@]12C",
        "output": "468"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CSc1ncc(N2CCC(C)CC2)n1-c1c(F)cc(F)cc1F.ClC(Cl)Cl.ClCCl.O=C1CCC(=O)N1Br.[Na+].[OH-]>>CSc1nc(Br)c(N2CCC(C)CC2)n1-c1c(F)cc(F)cc1F",
        "output": "665"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "N#Cc1ccc(N(Cc2ccccc2C(F)(F)F)[C@H]2CCNC2)cc1.O=C1CCCC1>>N#Cc1ccc(N(Cc2ccccc2C(F)(F)F)[C@H]2CCN(C3CCCC3)C2)cc1",
        "output": "187"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCNCC2)c1.O=Cc1sccc1Oc1ccccc1>>CC(C)C(=O)Nc1cccc(C2CCN(Cc3sccc3Oc3ccccc3)CC2)c1",
        "output": "792"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CC[C@H](N)C1.CCOC(C)=O.ClCCCCOc1ccccn1.O.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CC(C)(C)OC(=O)N1CC[C@H](NCCCCOc2ccccn2)C1",
        "output": "279"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)c1ccc(C(=O)O)cc1.CN(C)C=O.CO.COc1cc(OC(C)(C)C(=O)O)c(-c2cccs2)cc1C=O.C[O-].Cl.O.[Li+]>>COc1cc(OC(C)(C)C(=O)O)c(-c2cccs2)cc1/C=C/C(=O)c1ccc(C(=O)O)cc1",
        "output": "656"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)(C)O[Na].Cc1ccc2cc(Br)ccc2n1.Cc1ccccc1C(=O)c1ccc(N)cc1Cl>>Cc1ccc2cc(Nc3ccc(C(=O)c4ccccc4C)c(Cl)c3)ccc2n1",
        "output": "405"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CCN(CC)CC.Cl.Clc1cccc(N2CCNCC2)c1Cl.O=CCCCOc1ccc2ccc(=O)[nH]c2n1.[Na+]>>O=c1ccc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nc2[nH]1",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1ccccc1-c1cc(N2CCNCC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.ClCCl>>Cc1ccccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "584"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)NC(=O)c1cccc(CN2CCNCC2)c1.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.CCOC(C)=O.ClCCl.Nc1ccc(C(=O)O)c(Cl)c1F>>CC(C)(C)NC(=O)c1cccc(CN2CCN(C(=O)c3ccc(N)c(F)c3Cl)CC2)c1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)[C@H](CNC(=O)N1CCN(c2cccc(NC3=NCCCN3)c2)CC1)NC(=O)OCc1ccccc1.O=C(O)C(F)(F)F.[Na+].[OH-]>>O=C(N[C@@H](CNC(=O)N1CCN(c2cccc(NC3=NCCCN3)c2)CC1)C(=O)O)OCc1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.CCc1ccc2nc(C)[nH]c2c1N1CC(CN)OC1=O.c1ccncc1>>CCc1ccc2nc(C)[nH]c2c1N1CC(CNC(C)=O)OC1=O",
        "output": "339"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)C(C(O)CC)N(Cc1ccccc1)Cc1ccccc1.O.O.[Li+].[OH-]>>CCC(O)C(C(=O)O)N(Cc1ccccc1)Cc1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.O.O=C(c1ccccc1)C1(F)CCC1.[BH4-].[Na+]>>OC(c1ccccc1)C1(F)CCC1",
        "output": "24"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O[Pd]c1ccccc1-c1ccccc1P(C(C)(C)C)C(C)(C)C.CCO.CN1Cc2ccc(Cl)nc2O[C@H](c2ccccc2)C1.COCCOC.Cn1cc(-c2ccc(N)cc2)cn1.O=C([O-])[O-].[Cs+].[Cs+]>>CN1Cc2ccc(Nc3ccc(-c4cnn(C)c4)cc3)nc2O[C@H](c2ccccc2)C1",
        "output": "434"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cn1c(N2CCNCC2)nc2ccccc21.O=C(NCC(F)(F)C(F)(F)F)C1(CCCCBr)c2ccccc2-c2ccccc21>>Cn1c(N2CCN(CCCCC3(C(=O)NCC(F)(F)C(F)(F)F)c4ccccc4-c4ccccc43)CC2)nc2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc2scnc2c1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CS(C)=O.[K+]>>CC1(C)OB(c2ccc3scnc3c2)OC1(C)C",
        "output": "934"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCO.NCc1cccc(O)c1>>CC(C)(C)OC(=O)NCc1cccc(O)c1",
        "output": "686"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCO.CCOC(=O)COc1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1.[Li+].[OH-]>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(OCC(=O)O)cc2)CC1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NC1CCc2ccc(O)cc2C1Cc1ccccc1.CCN(CC)CC.ClCCl.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)NC1CCc2ccc(OS(=O)(=O)C(F)(F)F)cc2C1Cc1ccccc1",
        "output": "843"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.CC(=O)O.CC(=O)OC(C)=O.Nc1ccccc1N>>Nc1ccc(Br)cc1N",
        "output": "98"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1ccccn1.O=C(O)CSc1nc(-c2ccc(F)cc2)cs1>>O=C(CSc1nc(-c2ccc(F)cc2)cs1)Nc1ccccn1",
        "output": "368"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cc1nc2cccc3n(CC4CCN(C(=O)OC(C)(C)C)CC4)c(=O)c1n23.Cl>>Cc1nc2cccc3n(CC4CCNCC4)c(=O)c1n23",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1c(C#N)cccc1C(=O)O.O=S(Cl)Cl>>Cc1c(C#N)cccc1C(=O)Cl",
        "output": "3"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(-c2nc(CCl)co2)s1.Oc1ccc(CCCn2ccnc2)cc1>>COc1ccc(-c2nc(COc3ccc(CCCn4ccnc4)cc3)co2)s1",
        "output": "760"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1cc(C#N)ccc1C=O.ClCCl.O=C([O-])O.[Na+]>>N#Cc1ccc(C=O)c(O)c1",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=C([O-])[O-].O=[N+]([O-])c1cccnc1Cl.SCc1ccccc1.[Na+].[Na+]>>O=[N+]([O-])c1cccnc1SCc1ccccc1",
        "output": "333"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CNC.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cc(Br)ccc1F>>CN(C)C(=O)c1cc(Br)ccc1F",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COc1cccc(Cl)c1-c1nc(Cl)c2ccccc2n1.ClCCl>>Oc1cccc(Cl)c1-c1nc(Cl)c2ccccc2n1",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.C=C(C)C.CCCC(CCCN)C(=O)O.Cl.O.O=C=O.O=S(=O)(O)O>>CCCC(CCCN)C(=O)OC(C)(C)C",
        "output": "511"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccccc1N1CCNCC1.O=C(NCC(F)(F)F)C1(CCCCBr)c2ccccc2-c2ccccc21>>COc1ccccc1N1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.Cl[Pd]Cl.O=C(O)c1nc(Br)ccc1F.OB(O)c1ccc(OCc2ccccc2)cc1F.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=C(O)c1nc(-c2ccc(OCc3ccccc3)cc2F)ccc1F",
        "output": "869"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "B.C1CCOC1.C[C@H]1CN(Cc2cccc(-c3ccc(F)c(C#N)c3)c2)CCN1C(=O)OC(C)(C)C>>C[C@H]1CN(Cc2cccc(-c3ccc(F)c(CN)c3)c2)CCN1C(=O)OC(C)(C)C",
        "output": "175"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCC(=O)O.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCCCC2c2ccoc3cccc2-3)CC1>>COCC(=O)N[C@@H]1CC[C@@H](CCN2CCCCC2c2ccoc3cccc2-3)CC1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)CCC(=O)c1cccc(OCc2c(Cl)cccc2Cl)c1.[Na+].[OH-]>>O=C(O)CCC(=O)c1cccc(OCc2c(Cl)cccc2Cl)c1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1nccc(I)c1-c1nc(C)c(C(=O)OC(C)(C)C)[nH]1.ClCCl.O=C(O)C(F)(F)F>>COc1nccc(I)c1-c1nc(C)c(C(=O)O)[nH]1",
        "output": "569"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C[O-].Cc1ccccc1.FC1(F)CCC(Cc2c(Cl)nc3ccc(Br)cc3c2Cl)CC1.[Na+]>>COc1nc2ccc(Br)cc2c(Cl)c1CC1CCC(F)(F)CC1",
        "output": "433"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NC1(C2CN(C(=O)OCc3ccccc3)C2)CC1.CCO.[C].[Pd]>>CC(C)(C)OC(=O)NC1(C2CNC2)CC1",
        "output": "428"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCCCCC[C@H](Nc1ccc(F)cc1)C(=O)O.C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](OC(=O)N2Cc3cccc(F)c3C2)CN1)C(=O)S(=O)(=O)C1CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O.O=S(=O)([O-])O.[K+]>>C=CCCCCC[C@H](Nc1ccc(F)cc1)C(=O)N1C[C@H](OC(=O)N2Cc3cccc(F)c3C2)C[C@H]1C(=O)N[C@]1(C(=O)S(=O)(=O)C2CC2)C[C@H]1C=C",
        "output": "297"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COC(=O)[C@H]1CC[C@](O)(c2ncc(-c3cc(CO)cc(Nc4nccc(C(F)(F)F)n4)c3)s2)CC1(C)C.CS(=O)(=O)Cl.ClCCl>>COC(=O)[C@H]1CC[C@](O)(c2ncc(-c3cc(COS(C)(=O)=O)cc(Nc4nccc(C(F)(F)F)n4)c3)s2)CC1(C)C",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOc1ccccc1CN.CO.Nc1nc2cc(F)c(Sc3cccc(C=O)c3)cc2cc1CC1CCOCC1.[BH4-].[Na+].[Na+].[OH-]>>CCOc1ccccc1CNCc1cccc(Sc2cc3cc(CC4CCOCC4)c(N)nc3cc2F)c1",
        "output": "683"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.COc1cc(N2CCNCC2)c(F)cc1Cl.Cl.Cl.F[P-](F)(F)(F)(F)F.Nc1ncnc2c1c(-c1ncc[nH]1)nn2CC(=O)O>>COc1cc(N2CCN(C(=O)Cn3nc(-c4ncc[nH]4)c4c(N)ncnc43)CC2)c(F)cc1Cl",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#CCO.CC#N.[Cu]I.[N-]=[N+]=NC[C@H]1CN(c2ccc(I)c(F)c2)C(=O)O1>>O=C1O[C@@H](Cn2cc(CO)nn2)CN1c1ccc(I)c(F)c1",
        "output": "963"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCCCCCCCCCCBr.CN(C)P(=O)(N(C)C)N(C)C.N#Cc1ccc(N)cc1.O>>CCCCCCCCCCCCCCCCNc1ccc(C#N)cc1",
        "output": "273"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)C1=Cc2cc(Br)ccc2N(CCC(C)C)CC1.Cl.[Na+].[OH-]>>CC(C)CCN1CCC(C(=O)O)=Cc2cc(Br)ccc21",
        "output": "58"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.CO.C[C@@H](C(=O)O)[C@@H](O)c1ccc(Cl)cc1.Cc1cccc(C)n1.ClCCl.O=C([O-])[O-].[K+].[K+]>>C[C@@H](C(=O)O)[C@@H](O[Si](C)(C)C(C)(C)C)c1ccc(Cl)cc1",
        "output": "839"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COc1cccc(CO[Si](C)(C)C(C)(C)C)c1CC1COC(C)(C)O1.O.[F-]>>COc1cccc(CO)c1CC1COC(C)(C)O1",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.CNOC.COc1ccc(Cn2cc(C(=O)O)c(=O)c3ccccc32)cc1.Cl>>COc1ccc(Cn2cc(C(=O)N(C)OC)c(=O)c3ccccc32)cc1",
        "output": "879"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Fc1ccc(-c2ccncn2)c(OC2CCN(Cc3ccccc3)C2)c1.O=C[O-].[NH4+].[Pd]>>Fc1ccc(-c2ccncn2)c(OC2CCNC2)c1",
        "output": "84"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)COC(=O)Cl.CC(C)[C@H](NC(=O)Oc1ccccc1)C(=O)O.CC(N)CN(C)c1ccc(F)cc1.CN1CCCCC1.ClCCl.O>>CC(CN(C)c1ccc(F)cc1)NC(=O)[C@@H](NC(=O)Oc1ccccc1)C(C)C",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)CCCCCCCCCCCCCO.O=C(O)c1cccnc1.O=S(Cl)Cl>>CC(C)CCCCCCCCCCCCCOC(=O)c1cccnc1",
        "output": "521"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.CC(C)(C)[Si](C)(C)OC/C(=C(\\CO)c1ccc(S(C)(=O)=O)cc1)c1ccccc1.CN(C)c1ccncc1.ClCCl>>CC(=O)OC/C(=C(\\CO[Si](C)(C)C(C)(C)C)c1ccccc1)c1ccc(S(C)(=O)=O)cc1",
        "output": "155"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)CCSc1cccc(B(O)O)c1.O=C1CN(c2cccc(-n3cc(-c4ccc(F)cc4F)nc3Cc3ccc(Br)cc3)c2)S(=O)(=O)N1>>CC(C)(C)CCSc1cccc(-c2ccc(Cc3nc(-c4ccc(F)cc4F)cn3-c3cccc(N4CC(=O)NS4(=O)=O)c3)cc2)c1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.N#Cc1cccc(-c2nc3c(o2)CCNC3)c1.N#Cc1cccc(C(=O)O)c1.N#Cc1cccnc1Cl>>N#Cc1cccc(-c2nc3c(o2)CCN(c2ncccc2C#N)C3)c1",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)NCCc1c(O)cccc1F.COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCCOS(=O)(=O)c2ccc(C)cc2)cc1>>COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCCOc2cccc(F)c2CCNC(C)=O)cc1",
        "output": "438"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1nc(C)n(-c2ccc3c(c2)CCO3)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1nc(C)n(-c2ccc3c(c2)CCO3)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cc(S)n2ncnc2n1.O.[K+].[OH-]>>O=C(O)c1cc(S)n2ncnc2n1",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.O=C1CC2CCC(C1)N2>>CC(C)(C)OC(=O)N1C2CCC1CC(=O)C2",
        "output": "694"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3nc(Br)cn4ccnc34)nc2)CC1.ClCCl.O=C(O)C(F)(F)F>>Brc1cn2ccnc2c(Nc2ccc(N3CCNCC3)cn2)n1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OC1CCc2c1cccc2C(O)C(F)F.CI.O.[H-].[Na+]>>COC(c1cccc2c1CCC2O[Si](C)(C)C(C)(C)C)C(F)F",
        "output": "140"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC1(C)OB(c2ccc(N)cc2F)OC1(C)C.O=C(Cl)Oc1ccccc1.O=C([O-])O.[Na+]>>CC1(C)OB(c2ccc(NC(=O)Oc3ccccc3)cc2F)OC1(C)C",
        "output": "102"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1cccnc1.C#Cc1ccc2c(c1)CCC(=O)N2.Cl[Pd]Cl.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C1CCc2cc(C#Cc3cccnc3)ccc2N1",
        "output": "719"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.Nc1ccc(Cl)cc1F.O.O=C1OC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1c1ccc(Cl)cc1F",
        "output": "475"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)c1ccc(-c2ccc(O)cc2)cc1NC(=O)c1ccccc1.O=C(O)C(F)(F)F>>O=C(Nc1cc(-c2ccc(O)cc2)ccc1C(=O)O)c1ccccc1",
        "output": "752"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC1)NC(Cc1ccccc1)C(=O)N2Cc1ccccc1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>O=C1C(Cc2ccccc2)NC2(CCNCC2)N1Cc1ccccc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOc1ccccc1CN.COc1cc2c(cc1OC)C(Cc1ccc(OC)c(OC)c1OC)NCC2.O=C(Br)CBr>>CCOc1ccccc1CNC(=O)CN1CCc2cc(OC)c(OC)cc2C1Cc1ccc(OC)c(OC)c1OC",
        "output": "946"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.CC1NC(=O)NN=C1c1ccc2c(c1)CCC(=O)N2CCOCc1ccccc1.CO.ClCCl>>CC1NC(=O)NN=C1c1ccc2c(c1)CCC(=O)N2CCO",
        "output": "178"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cccnc1Br.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cc1ccc[n+]([O-])c1Br",
        "output": "262"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(C)=O.CCc1c(OCc2ccccc2)c(=O)ccn1CCOC(=O)C(C)C.CN(C)C=O.[Pd]>>CCc1c(O)c(=O)ccn1CCOC(=O)C(C)C",
        "output": "264"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CCN(C(C)C)C(C)C.ClCCl.Nc1c(F)cccc1[N+](=O)[O-]>>CC(=O)Nc1c(F)cccc1[N+](=O)[O-]",
        "output": "9"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCOc1cc(N)c(F)cc1Cl.CCN(CC)CC.CCOC(=O)C1CCCCC1C(=O)O.Cl.ClCCl.O=S(Cl)Cl.c1ccncc1>>C=CCOc1cc(NC(=O)C2CCCCC2C(=O)OCC)c(F)cc1Cl",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NCc1cc(F)c(Cl)c(Nc2nc3cc(C(=O)N[C@@H]4CC[C@@H](C(F)(F)F)CC4)c(N4CCC(F)CC4)nc3[nH]2)c1Cl.Cl>>NCc1cc(F)c(Cl)c(Nc2nc3cc(C(=O)N[C@@H]4CC[C@@H](C(F)(F)F)CC4)c(N4CCC(F)CC4)nc3[nH]2)c1Cl",
        "output": "793"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1=CCCCC1.C1CCOC1.C=CCC(CF)NC(=O)OC.CCOC(C)=O.CCOCC.O.OO.[Na+].[OH-]>>COC(=O)NC(CF)CCCO",
        "output": "465"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccccc1.CC(O)Cn1nc2c3c(cc(O)cc31)CCC2.CCO.O=C([O-])[O-].[K+].[K+]>>CC(O)Cn1nc2c3c(cc(OCc4ccccc4)cc31)CCC2",
        "output": "127"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1cc(OC)c(N)cc1C.COC(=O)c1cc(OC)c([N+](=O)[O-])cc1F>>COC(=O)c1cc(OC)c(N)cc1F",
        "output": "772"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N=c1n(CCCOc2cccc(C(=O)O)c2)c2ccccc2n1Cc1cccc(Br)c1.CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCNCC2)C1.Cc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3cccc(Cn4c(=NC(=O)OC(C)(C)C)n(CCCOc5cccc(C(=O)O)c5)c5ccccc54)c3)CC2)C1",
        "output": "953"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=O.Cl.ClCCl.Cn1cc(Nc2ncc(Cl)c(NC[C@H]3CCCN3)n2)cn1>>CCNC(=O)N1CCC[C@@H]1CNc1nc(Nc2cnn(C)c2)ncc1Cl",
        "output": "437"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCc1nc(N)cc(Cl)n1.CO.ClC(Cl)Cl.O.[Na]>>CCCc1nc(N)cc(OC)n1",
        "output": "653"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)NCCN.CCN(C(C)C)C(C)C.O=[N+]([O-])c1cnc(Cl)nc1Cl>>CC(=O)NCCNc1nc(Cl)ncc1[N+](=O)[O-]",
        "output": "110"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)Nc1cc(OC(F)(F)F)ccc1F.II.[Cl-].[Li]C(C)CC.[NH4+]>>CCOC(=O)Nc1c(F)ccc(OC(F)(F)F)c1I",
        "output": "372"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1C(=O)C2(COc3cc4c(cc32)OCO4)c2c(Br)cccc21.O=C1N(Cc2ccc(C(F)(F)F)o2)c2cccc(Br)c2C12COc1cc3c(cc12)CCO3.OB(O)c1ccc(F)nc1.OB(O)c1cncnc1>>CN1C(=O)C2(COc3cc4c(cc32)OCO4)c2c(-c3ccc(F)nc3)cccc21",
        "output": "899"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COc1ccc(C(C)(C)CO)cc1B1OC(C)(C)C(C)(C)O1.C[C@H]1C[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1nc(Cl)ccc1Br.O=C([O-])[O-].[K+].[K+]>>COc1ccc(C(C)(C)CO)cc1-c1ccc(Cl)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C[C@@H]1C",
        "output": "938"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cl.O=C(O)Cc1csc(NC(=O)C(CC2CCCC2)c2ccc(Oc3ccccc3)cc2)n1>>COC(=O)Cc1csc(NC(=O)C(CC2CCCC2)c2ccc(Oc3ccccc3)cc2)n1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)OC(=O)N1CCC(O)C(Sc2ccc(Br)cc2)C1>>CC(C)(C)OC(=O)N1CCC(=O)C(Sc2ccc(Br)cc2)C1",
        "output": "87"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.COc1ncccc1-c1[nH]c2ccccc2c1C1CCNCC1.ClCCl.O=S(=O)(Cl)c1ccccc1>>COc1ncccc1-c1[nH]c2ccccc2c1C1CCN(S(=O)(=O)c2ccccc2)CC1",
        "output": "99"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)CCN.F[B-](F)(F)F.O=C(O)c1cccc(Nc2cncc(-c3ccc(O)cc3)n2)c1>>CN(C)CCNC(=O)c1cccc(Nc2cncc(-c3ccc(O)cc3)n2)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.COc1ccc2c(c1)C(C)(C)C(=O)CC2.O.O=C1CCC(=O)N1Br>>COc1cc2c(cc1Br)CCC(=O)C2(C)C",
        "output": "4"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCCCc1ccccc1OCc1ccccc1.CCO.[H][H].[Pd]>>CC(C)(C)OC(=O)NCCCc1ccccc1O",
        "output": "23"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1c(N2CCN(C)CC2=O)nc2cc(F)cc(F)c2c1Cl.Cc1ccccc1.Nc1cc(N2CCOCC2)cnc1N1CCOCC1>>Cc1c(N2CCN(C)CC2=O)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)cnc1N1CCOCC1",
        "output": "859"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.COc1cc(C=O)cc(C=O)c1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.O.O=C([O-])[O-].[Br-].[K+].[K+]>>C=Cc1cc(C=O)cc(OC)c1",
        "output": "649"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Nc1nc2cc(Cl)ccc2nc1OC.COc1cc(N2CCNCC2)cc(OC)c1OC>>COc1cc(N2CCN(C(=O)Nc3nc4cc(Cl)ccc4nc3OC)CC2)cc(OC)c1OC",
        "output": "613"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1c([N+](=O)[O-])ccc(C(N)=O)c1OC.CO.[Pd]>>CCc1c(N)ccc(C(N)=O)c1OC",
        "output": "28"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CC2(CCOCC2)CN1.N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1F>>N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1N1CCC2(CCOCC2)C1",
        "output": "26"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CI.OC1CCN(Cc2ccccc2)C1.[H-].[Na+]>>COC1CCN(Cc2ccccc2)C1",
        "output": "140"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.C1COCCO1.CC(=O)O.Cl.O=C(O)C=Cc1ccc([N+](=O)[O-])cc1.[Zn]>>Nc1ccc(C=CC(=O)O)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)Oc1ccc(C#N)cc1[N+](=O)[O-].CO.Cl[Ni]Cl.O.O.O.O.O.O.[BH4-].[Na+]>>CC(C)Oc1ccc(C#N)cc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CO.Nc1cccc(-n2cnc3cc(C(=O)NCc4cccnc4)ccc32)c1.O=Cc1ccc(Cl)cc1>>O=C(NCc1cccnc1)c1ccc2c(c1)ncn2-c1cccc(NCc2ccc(Cl)cc2)c1",
        "output": "359"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C1CCNCC1.CN(C)C=O.Cc1ccc(S(=O)(=O)OCCC2CCc3ccccc3O2)cc1>>CCOC(=O)C1CCN(CCC2CCc3ccccc3O2)CC1",
        "output": "429"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cccc(Nc2cc(Nc3ccc(Oc4ccccc4)cc3)ncn2)c1>>CCC(=O)Nc1cccc(Nc2cc(Nc3ccc(Oc4ccccc4)cc3)ncn2)c1",
        "output": "365"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC1CNc2ccccc2NC1=O.ClCCCl.O=C(Cl)C12CC3CC(CC(C3)C1)C2.c1ccncc1>>CC(C)(C)OC(=O)NC1CN(C(=O)C23CC4CC(CC(C4)C2)C3)c2ccccc2NC1=O",
        "output": "160"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C1CCN(c2nc(COc3ccc(CO)cc3OC)c(C)s2)CC1.Cc1ccccc1.O=S(Cl)Cl>>CCOC(=O)C1CCN(c2nc(COc3ccc(CCl)cc3OC)c(C)s2)CC1",
        "output": "81"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1CC(O)c2ccccc2N1.COc1cccc(C(=O)O)c1>>COc1cccc(C(=O)N2c3ccccc3C(O)CC2C)c1",
        "output": "873"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.CCCCCCCCCCCCCCCCCCOc1cc(O)cc(N(CC(=O)OC)CC(=O)OC)c1.CN(C)C=O.ClCCCCc1ccc2cc(OCc3ccccc3)c(OCc3ccccc3)cc2c1.O=C([O-])[O-].[I-].[Na+]>>CCCCCCCCCCCCCCCCCCOc1cc(OCCCCc2ccc3cc(OCc4ccccc4)c(OCc4ccccc4)cc3c2)cc(N(CC(=O)OC)CC(=O)OC)c1",
        "output": "74"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN.CO.O=Cc1ccc(F)c(C(F)(F)F)c1.O=S(=O)([O-])[O-].[BH4-].[Mg+2].[Na+]>>CNCc1ccc(F)c(C(F)(F)F)c1",
        "output": "468"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#CC(C)(C)O.CC(C)NC(C)C.CN(C)C=O.I[Cu]I.Nc1nc(-c2ccccc2)c(-c2ccnc(Nc3cccc(I)c3)n2)s1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(O)C#Cc1cccc(Nc2nccc(-c3sc(N)nc3-c3ccccc3)n2)c1",
        "output": "664"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccccc1.O=C(O)C1(c2ccc3c(c2)OC(F)(F)O3)CC1.O=S(Cl)Cl>>O=C(Cl)C1(c2ccc3c(c2)OC(F)(F)O3)CC1",
        "output": "53"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCNCC.Cl.ClCc1ccncc1.c1cc(CN2CCOCC2)ccn1>>CCN(CC)Cc1ccncc1",
        "output": "156"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.Fc1cnccc1-c1cc2cc(C(F)(F)F)ccc2o1.O.OCC(F)F.[H-].[Na+]>>FC(F)COc1cnccc1-c1cc2cc(C(F)(F)F)ccc2o1",
        "output": "823"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)c1ccc(Br)cc1.COB(OC)OC.[Li]CCCC>>CC(C)(C)c1ccc(B(O)O)cc1",
        "output": "789"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CN(C)C=O.FC(F)(F)Oc1ccccc1S.N#Cc1ccc(F)cc1.O=C([O-])[O-].[K+].[K+]>>N#Cc1ccc(Sc2ccccc2OC(F)(F)F)cc1",
        "output": "675"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.NC(=O)CN1CCN([C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1.O=C(Cl)C(=O)Cl>>N#CCN1CCN([C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1",
        "output": "172"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN1C(=O)N(c2cc(NC(=O)Nc3cccc(C(F)(F)F)c3)c(F)cc2Cl)Cc2cnc(SC)nc21.CN.O=C(OO)c1cccc(Cl)c1>>CCN1C(=O)N(c2cc(NC(=O)Nc3cccc(C(F)(F)F)c3)c(F)cc2Cl)Cc2cnc(NC)nc21",
        "output": "101"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOc1ccc([N+](=O)[O-])cc1-c1nc2cccnc2c(=O)[nH]1.ClCCl.O.[Na+].[OH-]>>CCOc1ccc(N)cc1-c1nc2cccnc2c(=O)[nH]1",
        "output": "202"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])c(N)c2)CC1.CO.[H][H].[Pd]>>CC(C)(C)OC(=O)N1CCN(c2ccc(N)c(N)c2)CC1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCCN(S(=O)(=O)c2cc(C(N)=O)ccc2F)CC1.CC(C)O.CCN(CC)CC.ClCCl.O=C=O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1CCCN(S(=O)(=O)c2cc(C#N)ccc2F)CC1",
        "output": "374"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)[Si](C)(C)O[C@@H](CN)c1ccc(O)c2[nH]c(=O)ccc12.CCN(C(C)C)C(C)C.CN(CCCn1c(=O)[nH]c2cc(C=O)ccc21)[C@@H]1CC[C@@H](OC(=O)C(O)(c2cccs2)c2cccs2)CC1.CO.[Na+]>>CN(CCCn1c(=O)[nH]c2cc(CNC[C@H](O[Si](C)(C)C(C)(C)C)c3ccc(O)c4[nH]c(=O)ccc34)ccc21)[C@@H]1CC[C@@H](OC(=O)C(O)(c2cccs2)c2cccs2)CC1",
        "output": "468"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CC(=O)[O-].COc1cc(C=O)ccc1OCc1ccccc1.Cl.NO.O.[Na+]>>COc1cc(C#N)ccc1OCc1ccccc1",
        "output": "453"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)CBr.O=[N+]([O-])c1ccc(NC2CCC(O)CC2)cc1C(F)(F)F.[H-].[Na+]>>CC(C)(C)OC(=O)COC1CCC(Nc2ccc([N+](=O)[O-])c(C(F)(F)F)c2)CC1",
        "output": "669"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)c1ccc(C(=O)Nc2ccc(C(=O)NN=C3C(=O)Nc4ccc(I)cc43)cc2)cc1.O.[Na+].[OH-]>>O=C1Nc2ccc(I)cc2C1=NNC(=O)c1ccc(NC(=O)c2ccc(C(=O)O)cc2)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOc1cccc(B(O)O)c1.Nc1ccc(Br)cc1>>CCOc1cccc(-c2ccc(N)cc2)c1",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=[N+]([O-])c1cccc(Br)c1F.[K+]>>CC1(C)OB(c2cccc([N+](=O)[O-])c2F)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1cc2cc(N)ccc2s1>>CCOC(=O)c1cc2cc(NC(=O)OC(C)(C)C)ccc2s1",
        "output": "735"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrB(Br)Br.COc1ccc2c(c1)CCCC2(C)C.ClCCl>>CC1(C)CCCc2cc(O)ccc21",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)CC(=O)CC(C)(C)N1.[BH4-].[Na+]>>CC1(C)CC(O)CC(C)(C)N1",
        "output": "91"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)O.CN(CCN)C(=O)OC(C)(C)C.Nc1ccc(Sc2ccnc(Cl)n2)cc1>>CN(CCNc1nccc(Sc2ccc(N)cc2)n1)C(=O)OC(C)(C)C",
        "output": "544"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N(Cc1cccc(C(C)(C)C)c1)[C@H]1CSC[C@@H](Cc2ccc([N+](=O)[O-])c(F)c2)[C@H]1O.CCCCCC.CCOC(C)=O.N.O.O=S([O-])OO.[K+]>>CC(C)(C)OC(=O)N(Cc1cccc(C(C)(C)C)c1)[C@H]1CS(=O)(=O)C[C@@H](Cc2ccc([N+](=O)[O-])c(F)c2)[C@H]1O",
        "output": "847"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCOCC1.COc1cccc(C(=O)O)c1.COc1cnc(C2CCOCC2)c2sc(N)nc12.F[P-](F)(F)(F)(F)F>>COc1cccc(C(=O)Nc2nc3c(OC)cnc(C4CCOCC4)c3s2)c1",
        "output": "918"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)c1ccncc1.COc1c(C(C)(C)C)cc(C(=O)O)cc1C(C)(C)C.ClCCCl.ClCCl.NCC1CCN(C(=O)CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)C1>>COc1c(C(C)(C)C)cc(C(=O)NCC2CCN(C(=O)CCCCC(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1C(C)(C)C",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(=O)(=O)Cl.C[C@H]1CC[C@@H](Nc2ncc(-c3ccc(N4CCOCC4)cc3)c(OCC3CCNCC3)n2)CC1>>C[C@H]1CC[C@@H](Nc2ncc(-c3ccc(N4CCOCC4)cc3)c(OCC3CCN(S(C)(=O)=O)CC3)n2)CC1",
        "output": "584"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCC(O)CCCC.CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.[Na+]>>CCCCC(CCCC)OC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(C)c1C",
        "output": "960"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cnn(Cc2nc(-c3cccc([N+](=O)[O-])c3)cs2)c1.Cl.O.OCCC1CCCO1.[Cl-].[Na+].[Na+].[OH-]>>O=C(O)c1cnn(Cc2nc(-c3cccc([N+](=O)[O-])c3)cs2)c1",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.O=C(Oc1ccc(O)cc1)c1ccccc1.O=[N+]([O-])O>>O=C(Oc1ccc(O)c([N+](=O)[O-])c1)c1ccccc1",
        "output": "21"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)C(C)(C)CCCOc1ccc(CCC(=O)c2ccc(-c3ccc(C(F)(F)F)cc3)s2)c(Cl)c1Cl.[Na+].[OH-]>>CC(C)(CCCOc1ccc(CCC(=O)c2ccc(-c3ccc(C(F)(F)F)cc3)s2)c(Cl)c1Cl)C(=O)O",
        "output": "361"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.CCOCC.COc1ccccc1-c1cccc2cc(C(=O)N[C@H]3CN4CCC3CC4)oc12.Cl.ClCCl.O.[Na+].[OH-]>>O=C(N[C@H]1CN2CCC1CC2)c1cc2cccc(-c3ccccc3O)c2o1",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.CO.C[O-].Clc1cnc2c(Cl)nccc2n1.O.[Na+]>>COc1cnc2c(Cl)nccc2n1",
        "output": "209"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C(=O)c1ccccc1)C1CC(CO)C(c2ccccc2)C1.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CN(C(=O)c1ccccc1)C1CC(C=O)C(c2ccccc2)C1",
        "output": "142"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)CC1(C)CCc2c(C)c(S(=O)(=O)NC(=N)c3ccccc3)c(C)c(C)c2O1.CCOC(C)=O.Cl.[Na+].[OH-]>>Cc1c(C)c(S(=O)(=O)NC(=N)c2ccccc2)c(C)c2c1OC(C)(CC(=O)O)CC2",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)[O-].CCO.Cl.NO.O=Cc1c(F)ccc(F)c1Cl.[Na+]>>ON=Cc1c(F)ccc(F)c1Cl",
        "output": "30"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1ccn2nc(N3CCCC3)nc2c1.Cl.ClCCl>>Nc1ccn2nc(N3CCCC3)nc2c1",
        "output": "782"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1cnc(O[C@H]2CN3CCC2CC3)nc1.Nc1cccc(B(O)O)c1>>Nc1cccc(-c2cnc(O[C@H]3CN4CCC3CC4)nc2)c1",
        "output": "871"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.COc1ccc(CCN)cc1OC.Cc1ccc(CC(=O)O)cc1.Cc1ccccc1.O.O=S(Cl)Cl>>COc1ccc(CCNC(=O)Cc2ccc(C)cc2)cc1OC",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=C(O)CCCc1[nH]nc(-c2ccc(F)cc2)c1-c1ccncc1.O=S(=O)(O)O>>COC(=O)CCCc1[nH]nc(-c2ccc(F)cc2)c1-c1ccncc1",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.COCCOCCO.COc1ccc2cc(Cl)n(C)c(=O)c2c1.Cl[Pd]Cl.O.O=C(O)c1ccc(B(O)O)cc1.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1ccc2cc(-c3ccc(C(=O)O)cc3)n(C)c(=O)c2c1",
        "output": "865"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].COc1ccc(N2CCNCC2)cc1.Cc1c(C)c2c(c(C)c1Br)CC(C)(C)O2.Cc1ccccc1.O.[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COc1ccc(N2CCN(c3c(C)c(C)c4c(c3C)CC(C)(C)O4)CC2)cc1",
        "output": "294"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(Cl)Cl.CCO.O=[N+]([O-])c1ccc2c(c1)N(S(=O)(=O)c1ccc(F)cc1)CCC2.[H][H].[OH-].[OH-].[Pd+2]>>Nc1ccc2c(c1)N(S(=O)(=O)c1ccc(F)cc1)CCC2",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O.CN(C)c1ccncc1.COc1ccc(COC(=O)c2ccc(OCCO)cc2)cc1.ClCCl>>COc1ccc(COC(=O)c2ccc(OCCOC(=O)[C@@H](NC(=O)OCc3ccccc3)C(C)C)cc2)cc1",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.COCCOCC#Cc1cc(Cl)c(N)c2c1OCO2.COc1cc2c(Cl)ncnc2cc1OCCCN1CCOCC1.C[Si](C)(C)[N-][Si](C)(C)C.[Na+]>>COCCOCC#Cc1cc(Cl)c(Nc2ncnc3cc(OCCCN4CCOCC4)c(OC)cc23)c2c1OCO2",
        "output": "352"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COCOc1ccc(-c2cc(CCl)on2)c(C(F)(F)F)c1.Fc1cccc(-c2nc3cn[nH]cc-3n2)c1F.O=C([O-])[O-].[K+].[K+]>>COCOc1ccc(-c2cc(Cn3cc4nc(-c5cccc(F)c5F)nc-4cn3)on2)c(C(F)(F)F)c1",
        "output": "997"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.ClCCl.OC1CN(C(c2ccccc2)c2ccccc2)C1>>CS(=O)(=O)OC1CN(C(c2ccccc2)c2ccccc2)C1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N(c1cc2ccnc(Cl)c2cc1C)C1CCCC1.Oc1ccccc1.[K+].[OH-]>>CC(=O)N(c1cc2ccnc(Oc3ccccc3)c2cc1C)C1CCCC1",
        "output": "516"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COc1ccc(C(=O)CC(c2ccc(Br)cc2)c2ccccc2C)cn1.Cl>>Cc1ccccc1C(CC(=O)c1ccc(=O)[nH]c1)c1ccc(Br)cc1",
        "output": "758"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccccc1.O=C(O)c1ccc([N+](=O)[O-])c(Cl)c1.O=S(Cl)Cl>>O=C(Cl)c1ccc([N+](=O)[O-])c(Cl)c1",
        "output": "3"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCN(CC)C/C=C\\c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)OC)OCc1cccn1-2.CCO.Cc1ccccc1.O.O.O=CO.[Li+].[OH-]>>CCN(CC)C/C=C\\c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)OCc1cccn1-2",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)[Si](OCc1ccc(Br)cc1)(C(C)C)C(C)C.CCOC(C)=O.N#Cc1cccc(C=O)c1.[Cl-].[Li]CCCC.[NH4+]>>CC(C)[Si](OCc1ccc(C(O)c2cccc(C#N)c2)cc1)(C(C)C)C(C)C",
        "output": "379"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)c1cncc(C=O)c1.Cc1csc(CN(C)C(=O)c2cccc(C(=O)N[C@@H](Cc3ccccc3)[C@H](O)CN)c2)n1>>CC(=O)c1cncc(CNC[C@@H](O)[C@H](Cc2ccccc2)NC(=O)c2cccc(C(=O)N(C)Cc3nc(C)cs3)c2)c1",
        "output": "441"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].COC(=O)CCN.Cc1ccc([N+](=O)[O-])cc1Br.Cc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COC(=O)CCNc1cc([N+](=O)[O-])ccc1C",
        "output": "519"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F.Cc1cccc(C=O)c1>>Cc1cccc(C=CC(=O)c2cc(OCC(F)(F)F)ccc2OCC(F)(F)F)c1",
        "output": "295"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=O.O=C(O)/C=C/C(=O)O.O=CO.OC1(c2ccc(F)c(F)c2)CCNC1>>CN1CCC(O)(c2ccc(F)c(F)c2)C1",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(C2CCN(C(=O)c3ccc(-c4ccc5ncc(-c6ccc(C#N)cc6)n5c4)cc3)CC2)CC1.ClCCl.O=C(O)C(F)(F)F>>N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)N5CCC(N6CCNCC6)CC5)cc4)cn23)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.Cc1c(C=O)sc2c(N3CCOCC3)nc(Cl)nc12>>Cc1c(CN2CCN(C(=O)OC(C)(C)C)CC2)sc2c(N3CCOCC3)nc(Cl)nc12",
        "output": "792"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].Cc1ccccc1.FC(F)(F)c1cccc(I)c1.O=C([O-])[O-].O=C1CCNCCN1CCCN1CCCCC1.[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>O=C1CCN(c2cccc(C(F)(F)F)c2)CCN1CCCN1CCCCC1",
        "output": "931"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCOc2ccc(-c3cnc(N)o3)cc2C1.Cl>>Nc1ncc(-c2ccc3c(c2)CNCCO3)o1",
        "output": "887"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CC(C)(C)OC(=O)NCCSSCCN.CCN(C(C)C)C(C)C.N#CC#Cc1ccc(C(=O)Cl)cc1>>CC(C)(C)OC(=O)NCCSSCCNC(=O)c1ccc(C#CC#N)cc1",
        "output": "271"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCOC(C)=O.CO.ClCCl.O=C(Cl)c1ccc(Cl)c(F)c1Cl.O=C([O-])O.[Na+].c1nsc(-c2nnc3n2CCNC3)n1>>O=C(c1ccc(Cl)c(F)c1Cl)N1CCn2c(nnc2-c2ncns2)C1",
        "output": "201"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=C(NCCO)[C@@H]1CCCN1C(=O)OCc1ccccc1.[C].[Pd]>>O=C(NCCO)[C@@H]1CCCN1",
        "output": "568"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)/N=N/C(=O)OCC.CN1CCC(O)CC1.O=Cc1cccc(O)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN1CCC(Oc2cccc(C=O)c2)CC1",
        "output": "846"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)c1ccc(CC2CCN(C3CCCCC3)C2=O)cc1.[Na+].[OH-]>>O=C(O)c1ccc(CC2CCN(C3CCCCC3)C2=O)cc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)C(F)c1ccccc1-c1ccccc1F.Cl.O.O.[Li+].[OH-]>>O=C(O)C(F)c1ccccc1-c1ccccc1F",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C(C)(C)Br.CCOC(C)=O.CN(C)C=O.Cc1cc(CCCC2CN(Cc3ccc(C(C)(C)C)cc3)C(=O)N2C)ccc1O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C(C)(C)Oc1ccc(CCCC2CN(Cc3ccc(C(C)(C)C)cc3)C(=O)N2C)cc1C",
        "output": "305"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.COC1=C(OC)C(=O)C2=C(CCC(CCO)CC2)C1=O.Oc1ccc(F)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC1=C(OC)C(=O)C2=C(CCC(CCOc3ccc(F)cc3)CC2)C1=O",
        "output": "478"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COc1ccc2c(O)c(-c3ccc(SC)cc3)ccc2c1.O.O=[N+]([O-])c1ccc(F)cc1.[H-].[Na+]>>COc1ccc2c(Oc3ccc([N+](=O)[O-])cc3)c(-c3ccc(SC)cc3)ccc2c1",
        "output": "564"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "II.O=C(O)c1ccc(Cl)cc1Cl.O=S(=O)(O)O.[Na+].[O-][I+2]([O-])[O-]>>O=C(O)c1cc(I)c(Cl)cc1Cl",
        "output": "372"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc3ccccc3c2)cc1.Cl.[Li+].[OH-]>>O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc3ccccc3c2)cc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)[C@@H]1CCC(=O)N1Cc1cccc(COc2ccc(-c3cc(F)c(F)cc3OC)cc2)c1.CO.[Li+].[OH-]>>COc1cc(F)c(F)cc1-c1ccc(OCc2cccc(CN3C(=O)CC[C@H]3C(=O)O)c2)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Cl.O.O=C1CCC(NC(=O)OCc2ccccc2)(c2ccc(F)cc2)CC1.[BH4-].[Na+]>>O=C(NC1(c2ccc(F)cc2)CCC(O)CC1)OCc1ccccc1",
        "output": "91"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)C(F)(F)c1cccc(CCCS(C)(=O)=O)c1.CO.O.O.[Li+].[OH-]>>CS(=O)(=O)CCCc1cccc(C(F)(F)C(=O)O)c1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "B.C1CCOC1.O=C(O)Cc1ccc(Br)cc1F>>OCCc1ccc(Br)cc1F",
        "output": "231"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)N.CS(C)=O.[O-][n+]1c(Cl)cccc1Cl>>CC(C)Nc1cccc(Cl)[n+]1[O-]",
        "output": "70"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(CO)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-n3ncc4cc(Cl)ccc43)nc12.ClCCl.O=C(O)C(F)(F)F>>CC(C)(CO)NC(=O)c1c[nH]c2ncc(-n3ncc4cc(Cl)ccc43)nc12",
        "output": "981"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.CCOCC.FB(F)F.O=C(O)c1ccc(Br)c(F)c1.[BH4-].[Na+]>>OCc1ccc(Br)c(F)c1",
        "output": "72"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.Cc1ccc(S(=O)(=O)O)cc1.O.O=C1NCCC12CCC1(CC2)OCCO1.[Na+].[OH-]>>O=C1CCC2(CCNC2=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(CC)CC1CCCCN1CCCN.O=C1Nc2cccnc2N(C(=O)Cl)c2ccccc21>>CCN(CC)CC1CCCCN1CCCNC(=O)N1c2ccccc2C(=O)Nc2cccnc21",
        "output": "454"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CC(n2cc(Nc3ncc(Cl)c(CCc4ccccc4C4(C(N)=O)CC4)n3)cn2)C1.ClCCl.O=C(O)C(F)(F)F>>NC(=O)C1(c2ccccc2CCc2nc(Nc3cnn(C4CNC4)c3)ncc2Cl)CC1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)OC(C)C.N#Cc1cccc(S(=O)(=O)Cl)c1.NC1CCCCNC1=O.[Na+].[OH-]>>N#Cc1cccc(S(=O)(=O)NC2CCCCNC2=O)c1",
        "output": "596"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COC(=O)c1ccc2[nH]cc(C3(C#N)CCC3)c2c1.O=[Pt]=O>>COC(=O)c1ccc2[nH]cc(C3(CN)CCC3)c2c1",
        "output": "246"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.Nc1ccc(C(=O)O)c2c1OCCO2>>CC(=O)Nc1ccc(C(=O)O)c2c1OCCO2",
        "output": "6"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O.ClCCCBr.FC(F)(F)c1ccc([C@@]23CNC[C@@H]2C3)cc1>>FC(F)(F)c1ccc([C@]23C[C@H]2CN(CCCCl)C3)cc1",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cc1ccc(C(=O)O)c(Cl)n1.Cc1ccc(S(=O)(=O)O)cc1.O>>CCOC(=O)c1ccc(C)nc1Cl",
        "output": "521"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCCCCO.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>C=CCCCCOS(=O)(=O)c1ccc(C)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCO.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.O.c1ccncc1>>CCCCCCOS(=O)(=O)c1ccc(C)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](O)C1.CCN(CC)CC.CN(C)c1ccccn1.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.ClCCl>>Cc1ccc(S(=O)(=O)O[C@H]2CCN(C(=O)OC(C)(C)C)C2)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cc(F)cc2n1>>CC(=O)Nc1cccc(CCN2CCN(c3cc(F)cc4nc(C)ccc34)CC2)c1",
        "output": "9"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCOC(=O)CC1CCN(C(=O)CC2OC(c3cccc(OC)c3OC)c3cc(Cl)ccc3-c3c2noc3C(C)C)CC1.Cl.O>>COc1cccc(C2OC(CC(=O)N3CCC(CC(=O)O)CC3)c3noc(C(C)C)c3-c3ccc(Cl)cc32)c1OC",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(O)c1cccc(CO[Si](C)(C)C(C)(C)C)n1.CI.CN(C)C=O.[H-].[Na+]>>COC(C)(C)c1cccc(CO[Si](C)(C)C(C)(C)C)n1",
        "output": "140"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2cnc3c(c2)cc2n3CCNC2=O)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C1NCCn2c1cc1cc(OC3CCNCC3)cnc12",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=C1CCN(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)CC1.[BH4-].[Na+]>>O=S(=O)(c1ccc(OC(F)(F)F)cc1)N1CCC(O)CC1",
        "output": "91"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)OCC(C)(C)C.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>CC(C)(C)COS(=O)(=O)c1cc([N+](=O)[O-])ccc1CBr",
        "output": "29"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ncccc1-c1cc(C#N)ccc1Oc1cnc(OC(C)C)c(Cl)c1.CS(C)=O.O.O=C([O-])[O-].OO.[K+].[K+]>>COc1ncccc1-c1cc(C(N)=O)ccc1Oc1cnc(OC(C)C)c(Cl)c1",
        "output": "180"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(C(=O)c2cnc3ccccc3c2)ccc1OCc1ccccc1.O=C(O)C(F)(F)F>>COc1cc(C(=O)c2cnc3ccccc3c2)ccc1O",
        "output": "23"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C(O)CC(O)(CC(=O)O)C(=O)O.OCCOCCOCCOCCOCCOC12CC3CC(CC(C3)C1)C2>>CS(=O)(=O)OCCOCCOCCOCCOCCOC12CC3CC(CC(C3)C1)C2",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCCCCCCCCCCc1cccc(OCC)c1C(=O)Cl.CCN(CC)CC.ClCCl.N#Cc1ccc(N)cc1C(F)(F)F>>CCCCCCCCCCCCCCCc1cccc(OCC)c1C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1",
        "output": "11"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1CCCC1=O.CNC.COc1cc(C2=C(c3cn(CCCBr)c4ccccc34)C(=O)NC2=O)c2occc2c1>>COc1cc(C2=C(c3cn(CCCN(C)C)c4ccccc34)C(=O)NC2=O)c2occc2c1",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)CC/C=C\\CC[C@H]1[C@@H](c2cccnc2)OC[C@@H]1OCc1ccc(-c2ccccc2)cc1.[Na+].[OH-]>>O=C(O)CC/C=C\\CC[C@H]1[C@@H](c2cccnc2)OC[C@@H]1OCc1ccc(-c2ccccc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Cl.Clc1ccc2c(c1)CNCc1nnc(C3CCN(c4ncccn4)CC3)n1-2>>CC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ncccn3)CC2)C1",
        "output": "240"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccc(N2CCN(Cc3ccccc3)CC2)cc1>>Nc1ccc(N2CCN(Cc3ccccc3)CC2)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CC[C@H](CN)C1.CCN(CC)CC.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)N1CC[C@H](CNC(=O)OCc2ccccc2)C1",
        "output": "479"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COC(=O)C1(C)CCC(C(C)=O)CC1.Cl.[Na+].[OH-]>>CC(=O)C1CCC(C)(C(=O)O)CC1",
        "output": "361"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)[C@@H]1CC(O[Si](C)(C)C(C)(C)C)C[C@H]1CO.Oc1ccc(F)cc1>>CCOC(=O)[C@@H]1CC(O[Si](C)(C)C(C)(C)C)C[C@H]1COc1ccc(F)cc1",
        "output": "478"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCN(CC(=O)OCC)S(=O)(=O)N(CC=C)C(=O)OC(C)(C)C.ClCCl.[H-]>>C=CCN(CC=O)S(=O)(=O)N(CC=C)C(=O)OC(C)(C)C",
        "output": "260"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(CC(=O)O)cc1.CC(C)N.CCN(CC)CC.CN(C)c1ccncc1.ClCCCl.ClCCl.On1nnc2ccccc21>>CC(C)NC(=O)Cc1ccc(CNC(=O)OC(C)(C)C)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](OCCOCCOCCOCCO)(c1ccccc1)c1ccccc1.CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCCOCCOCCOCCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)C(C)=Cc1cc(OC)c(OC)cc1N.Cl.[Na+].[OH-]>>COc1cc(N)c(C=C(C)C(=O)O)cc1OC",
        "output": "122"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCCCCCCCBr.CN(C)C=O.Cc1cc(Br)cc(C)c1O.ClCCl.O.O=C([O-])[O-].[K+].[K+]>>Cc1cc(Br)cc(C)c1OCCCCCCCBr",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[O-].CC1CCCO1.C[C@H](O)C1CCOCC1.N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1F.[K+]>>C[C@H](Oc1ccc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)cc1C#N)C1CCOCC1",
        "output": "485"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COCCOCCOc1ccc2sc(C(=O)Nc3ccccc3NC(=O)OC(C)(C)C)cc2c1.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>COCCOCCOc1ccc2sc(C(=O)Nc3ccccc3N)cc2c1",
        "output": "782"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.NC(=O)Nc1cc(Br)ccc1O.[K+]>>CC1(C)OB(c2ccc(O)c(NC(N)=O)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COc1cc(C2CCCCC2)ccc1CC(=O)O.Cl>>COC(=O)Cc1ccc(C2CCCCC2)cc1OC",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CNS(=O)(=O)c1cc2c(c(C(=O)Cl)c1)OCCO2.ClC(Cl)Cl.NC1CCN(C2CCCCC2)C1.O>>CNS(=O)(=O)c1cc2c(c(C(=O)NC3CCN(C4CCCCC4)C3)c1)OCCO2",
        "output": "271"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CNC1.O=C(O)c1ccc(Br)cn1>>O=C(c1ccc(Br)cn1)N1CCC1",
        "output": "605"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.C[Si](C)(C)c1ccc2c(c1)cc(C(=O)O)n2Cc1cccc(F)c1.Cl.Nc1ccc(N2CCC2)nc1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>C[Si](C)(C)c1ccc2c(c1)cc(C(=O)Nc1ccc(N3CCC3)nc1)n2Cc1cccc(F)c1",
        "output": "776"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(Cl)Cl.CN(C)C=O.COC(=O)c1[nH]cc(-c2cccc(Br)c2)c1-c1ccccc1.O.O=P(Cl)(Cl)Cl>>COC(=O)c1[nH]c(C=O)c(-c2cccc(Br)c2)c1-c1ccccc1",
        "output": "641"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.O=C(O)c1cccnc1Cl.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OCc1cccnc1Cl",
        "output": "293"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)[C@@H]1CCCN1Cc1cc2cc3c(cc2c2cc(OCc4ccccc4)ccc12)OCO3.N>>O=C(O)[C@@H]1CCCN1Cc1cc2cc3c(cc2c2cc(OCc4ccccc4)ccc12)OCO3",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCN(CC(=O)O)CC1.F[P-](F)(F)(F)(F)F.Nc1ccc(C2CN=C3c4ccccc4NC(=O)N3C2)cc1>>CN1CCN(CC(=O)Nc2ccc(C3CN=C4c5ccccc5NC(=O)N4C3)cc2)CC1",
        "output": "365"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCc1cc2c(cc1CC)CC(N(CC(=O)c1ccc(OCc3ccccc3)c([N+](=O)[O-])c1)Cc1ccccc1)C2>>CCc1cc2c(cc1CC)CC(N(CC(=O)c1ccc(OCc3ccccc3)c(N)c1)Cc1ccccc1)C2",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CN1CCOCC1.F[P-](F)(F)(F)(F)F.O=C(O)C(O)(c1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)NCc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1C(=O)C(O)(c1ccccc1)c1ccccc1",
        "output": "297"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.Fc1cc2nc(COc3ccccc3)n(Cc3ccc(OC(F)(F)F)cc3)c2cc1N1CCNCC1.O=C(Cl)c1ccccc1>>O=C(c1ccccc1)N1CCN(c2cc3c(cc2F)nc(COc2ccccc2)n3Cc2ccc(OC(F)(F)F)cc2)CC1",
        "output": "201"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC(=O)Cl.CCN(CC)CC.ClC(Cl)Cl.ClCCl.NCc1ccc(CN2CCN(c3ccccc3)CC2)cc1>>CCC(=O)NCc1ccc(CN2CCN(c3ccccc3)CC2)cc1",
        "output": "206"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.CCOC(C)=O.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(Cl)c(Br)c1.O[C@H]1CCNC1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@H](O)C2)c(Br)c1",
        "output": "220"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc2c(c1)OC[C@@H](c1ccc(C)cc1)[C@H]2c1ccc(OCCN2CCCCC2)cc1.Cl.c1ccncc1>>Cc1ccc([C@@H]2COc3cc(O)ccc3[C@@H]2c2ccc(OCCN3CCCCC3)cc2)cc1",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COCCCc1cc(CN(C(=O)C(CNC(=O)OC(C)(C)C)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)C2CC2)c(Cl)c[n+]1[O-].Cl.ClCCl>>COCCCc1cc(CN(C(=O)C(CN)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)C2CC2)c(Cl)c[n+]1[O-]",
        "output": "538"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCN(CC)CC.Nc1ccnc(Cl)c1F.O=C(Cl)c1c(Cl)cccc1Cl>>O=C(Nc1ccnc(Cl)c1F)c1c(Cl)cccc1Cl",
        "output": "11"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCCOc1cccc2[nH]ccc12.OC1(c2ccc3cc(OCc4ccccc4)ccc3c2)CCNCC1>>OC1(c2ccc3cc(OCc4ccccc4)ccc3c2)CCN(CCCOc2cccc3[nH]ccc23)CC1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1cccc2ccccc12.C1CNCCN1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].Cc1ccccc1C.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.ClCCl.[K+].[Pd+2]>>c1ccc2c(N3CCNCC3)cccc2c1",
        "output": "294"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.C[Si](C)(C)CCOCn1nc(C=Cc2ccccc2)c2ccc([N+](=O)[O-])cc21.O.[Na+].[OH-]>>C[Si](C)(C)CCOCn1nc(C=Cc2ccccc2)c2ccc(N)cc21",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CNOC.COc1cc(I)cc(OC)c1C(=O)O.Cl.ClCCl.O=C(Cl)C(=O)Cl>>COc1cc(I)cc(OC)c1C(=O)N(C)OC",
        "output": "828"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)CCNC(=O)c1ccc(C(Nc2nc3ccc(F)cc3cc2C)C2CC(C)(C)C2)cc1.[Na+].[OH-]>>Cc1cc2cc(F)ccc2nc1NC(c1ccc(C(=O)NCCC(=O)O)cc1)C1CC(C)(C)C1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CO.Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2[N+](=O)[O-])CC1.[Pd]>>Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2N)CC1",
        "output": "489"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(CO)CCCN.ClCCl.O=C=NCCc1ccccc1>>CC(C)(CO)CCCNC(=O)NCCc1ccccc1",
        "output": "244"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](Oc2ccc(C(CO)Cc3cc4ccc(C#N)cc4[nH]3)cc2)C1.CCOC(=O)CBr.CN(C)C=O.[Cl-].[H-].[NH4+].[Na+]>>CCOC(=O)Cn1c(CC(CO)c2ccc(O[C@H]3CCN(C(=O)OC(C)(C)C)C3)cc2)cc2ccc(C#N)cc21",
        "output": "310"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.O=C(NC1CCNCC1)c1cc(=O)c2ccc(F)cc2o1.O=Cc1ccc2occc2c1.[Na+]>>O=C(NC1CCN(Cc2ccc3occc3c2)CC1)c1cc(=O)c2ccc(F)cc2o1",
        "output": "567"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(c2cccc(C=O)n2)OCCO1.CO.N#N.O.[BH4-].[Na+]>>CC1(c2cccc(CO)n2)OCCO1",
        "output": "745"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1.Cl.ClCCl.O>>O=S(=O)(c1ccc(C(F)(F)F)cc1)N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)C[C@H]1C/C=C/c1ccccc1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.O=C([O-])[O-].[Cl-].[K+].[K+].[Na+].[Na+]>>C(=C/c1ccccc1)\\C[C@@H]1CN(Cc2ccccc2)CCN1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Br.CC(=O)O.CCCCCC.COC(=O)CON=C(C(C)=O)C(=O)OC(C)(C)C.ClCCl.O=C([O-])[O-].[K+].[K+]>>COC(=O)CON=C(C(C)=O)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C(=O)OC(C)(C)C)C1CCN(c2ncnc3[nH]ccc23)CC1.O=C(O)C(F)(F)F>>CNC1CCN(c2ncnc3[nH]ccc23)CC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.Nc1cc(O)cc(O)c1.O.O=C(Cl)OCc1ccccc1.O=C([O-])O.[Na+]>>O=C(Nc1cc(O)cc(O)c1)OCc1ccccc1",
        "output": "509"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1ccc(-c2nn(-c3c(F)cccc3F)c3ccnc(OC)c23)cc1.O.[Na+].[OH-]>>COc1nccc2c1c(-c1ccc(C(=O)O)cc1)nn2-c1c(F)cccc1F",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.COC(C)(C)C.Cc1cccc(F)c1F.O.[Fe]>>Cc1c(Br)ccc(F)c1F",
        "output": "98"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)CC(c2cccc(N3CCCC3)c2)Nc2c(C(=O)O)cc(F)cc21.CN(C)c1ccncc1.CS(N)(=O)=O.ClCCl>>CC1(C)CC(c2cccc(N3CCCC3)c2)Nc2c(C(=O)NS(C)(=O)=O)cc(F)cc21",
        "output": "580"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COCCn1cc(C(=O)O)c2c(Cl)cccc21.Cl.F[P-](F)(F)(F)(F)F.NCC1(c2ccccc2)CCCCC1>>COCCn1cc(C(=O)NCC2(c3ccccc3)CCCCC2)c2c(Cl)cccc21",
        "output": "674"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.O.Oc1cccc2ccc(Cl)nc12>>Oc1cccc2ccc(N3CCOCC3)nc12",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCC.ClCCl.OCc1ccccc1I>>O=Cc1ccccc1I",
        "output": "179"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.Nc1ccccc1.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>O=C(Nc1ccccc1)C(F)(F)F",
        "output": "106"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CN(C23CC4CC(CC(C4)C2)C3)CCN1.CCO.Nc1cc(Cl)nc(N)n1>>Nc1cc(N2CCN(C34CC5CC(CC(C5)C3)C4)CC2)nc(N)n1",
        "output": "162"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)C1=C(CCc2ccccc2)CS[C@@H]2C(NC(=O)Cc3cccs3)C(=O)N12.O=C(O)C(F)(F)F>>O=C(Cc1cccs1)NC1C(=O)N2C(C(=O)O)=C(CCc3ccccc3)CS[C@H]12",
        "output": "158"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCC(N)CC.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)nc1Cl.[K+].[K+]>>CCC(CC)Nc1nc(Cl)ccc1[N+](=O)[O-]",
        "output": "70"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CSc1c(OCCCCNC(=O)OC(C)(C)C)cccc1OCc1ccccc1.ClCCl.O.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1c(OCCCCNC(=O)OC(C)(C)C)cccc1OCc1ccccc1",
        "output": "500"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.Fc1ccc2c(c1)CCN2.N#Cc1ccc(C(=O)O)cc1N1CCC(n2c(=O)[nH]c3ncccc32)CC1>>N#Cc1ccc(C(=O)N2CCc3cc(F)ccc32)cc1N1CCC(n2c(=O)[nH]c3ncccc32)CC1",
        "output": "873"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCN(CC)CC.CCO.Cc1nc(C#N)cc(Oc2ccc(CS(N)(=O)=O)cc2)n1.[H][H].[Pd]>>Cc1nc(CN)cc(Oc2ccc(CS(N)(=O)=O)cc2)n1",
        "output": "205"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)[C@H](Cc1ccccc1)NC(C)=O.COC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(C)=O.Cl.O=C([O-])[O-].[K+].[K+].[Pd]>>COC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O",
        "output": "631"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CN1CCC(CO)CC1.Cc1ccccc1.O.O=[N+]([O-])c1ccc(F)c(C(F)(F)F)c1.[Br-]>>CN1CCC(COc2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1",
        "output": "485"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)C1CCc2cc(Br)ccc2N1C(C)=O.O.[Li+].[OH-]>>CC(=O)N1c2ccc(Br)cc2CCC1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)C1CN(C(=O)OC(C)(C)C)CCC1O.Cl.O.[Li+].[OH-]>>CC(C)(C)OC(=O)N1CCC(O)C(C(=O)O)C1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNCC(=O)N1CCOCC1.CO.COC(=O)c1ccc2cc3n(c2c1)CC=Cc1ccccc1-3.Cl.F[P-](F)(F)(F)(F)F.O.[Na+].[OH-]>>O=C(O)c1ccc2cc3n(c2c1)CC=Cc1ccccc1-3",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc2nc(-c3ccc(N)cc3)sc2c1.Cl.Cl[Sn]Cl.O.O.O.O=N[O-].[K+].[Na+].[OH-]>>Cc1ccc2nc(-c3ccc(NN)cc3)sc2c1",
        "output": "109"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCCc1cc(N2CCC[C@@H](N)C2)nc(Cl)n1.CCN(CC)CC>>CCCCc1cc(N2CCC[C@@H](NC(=O)OC(C)(C)C)C2)nc(Cl)n1",
        "output": "631"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.COCCO.Cl.Clc1nccc(Nc2cc(CCc3cccc(OCC4CC4)c3)[nH]n2)n1.NCc1cc(C(N)=O)no1>>NC(=O)c1cc(CNc2nccc(Nc3cc(CCc4cccc(OCC5CC5)c4)[nH]n3)n2)on1",
        "output": "544"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1c(N(C)C)nc(-c2ccccc2)c([N+](=O)[O-])c1C(=O)OCC.CCOC(C)=O.[Pd]>>CCOC(=O)c1c(N(C)C)nc(-c2ccccc2)c(N)c1C(=O)OCC",
        "output": "269"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCS(=O)(=O)C(C)(C)c1cc(N2CCOC[C@@H]2C)nc(-c2ccc(N)cc2)n1.O=C(Cl)Oc1ccccc1.O=C([O-])O.[Na+]>>CCS(=O)(=O)C(C)(C)c1cc(N2CCOC[C@@H]2C)nc(-c2ccc(NC(=O)Oc3ccccc3)cc2)n1",
        "output": "102"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCCN.CO.ClCCl.O=Cc1cc([N+](=O)[O-])ccc1O.[BH4-].[Na+]>>CC(C)(C)OC(=O)NCCNCc1cc([N+](=O)[O-])ccc1O",
        "output": "468"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CC[C@H](N)c1cc2cccc(Cl)c2c(=O)n1C1CC1.Cn1cnc(-c2c(N)ncnc2Cl)n1>>CC[C@H](Nc1ncnc(N)c1-c1ncn(C)n1)c1cc2cccc(Cl)c2c(=O)n1C1CC1",
        "output": "110"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCNCCOC.Fc1ccc(-c2csc3cc(OCCCCBr)ccc23)cc1>>CCN(CCCCOc1ccc2c(-c3ccc(F)cc3)csc2c1)CCOC",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.Clc1ccc(C(c2ccccc2)N2CCNCC2)cc1.O=S(=O)(CCCCCCl)NCCO>>O=S(=O)(CCCCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCO",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.C=CCOc1ccc(CC(NC(=O)Cc2ccccc2)C(=O)NC(Cc2ccccc2)C(=O)O)cc1Cl.CCN(CC)CC.COC(=O)CN.Cl.ClC(Cl)Cl>>C=CCOc1ccc(CC(NC(=O)Cc2ccccc2)C(=O)NC(Cc2ccccc2)C(=O)NCC(=O)OC)cc1Cl",
        "output": "129"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.COc1cc(CC(=O)O)ccc1N.Cc1ccc(S(=O)(=O)O)cc1.Clc1ncc(Cl)c(-c2cnc3ccccn23)n1.O>>COc1cc(CC(=O)O)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1",
        "output": "808"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.CC1(C)C(=O)N(c2ccc(OC(F)(F)F)cc2)C(=O)N1Cc1ccnc(Cl)c1.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CC1(C)C(=O)N(c2ccc(OC(F)(F)F)cc2)C(=O)N1Cc1ccnc(N2CCOCC2)c1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCC(CC)(c1ccc(OCC(=O)C(C)(C)C)c(C)c1)c1cc2cc(C(=O)Nc3nn[nH]n3)ccc2o1.[BH4-].[Na+]>>CCC(CC)(c1ccc(OCC(O)C(C)(C)C)c(C)c1)c1cc2cc(C(=O)Nc3nn[nH]n3)ccc2o1",
        "output": "91"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=O.CC(=O)O.CO.Cc1nccn1-c1ccc(Nc2nc3c(c(N(CCC#N)C4CC4)n2)CNCC3)cc1.[BH3-]C#N.[Na+]>>Cc1nccn1-c1ccc(Nc2nc3c(c(N(CCC#N)C4CC4)n2)CN(C)CC3)cc1",
        "output": "217"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCC1CC1.CN(C)C=O.COC(=O)c1ccc(O)c(C#N)c1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(OCC2CC2)c(C#N)c1",
        "output": "385"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(O)Cc1ccc(Cl)c(O)c1.O=S(=O)(c1ccccc1)c1ccc(F)c(F)c1>>O=C(O)Cc1ccc(Cl)c(Oc2ccc(S(=O)(=O)c3ccccc3)cc2F)c1",
        "output": "564"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.N#CCN(c1ccc(Cl)cc1)c1nc(=O)c2cccnc2s1.O.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>O=c1nc(N(Cc2nnn[nH]2)c2ccc(Cl)cc2)sc2ncccc12",
        "output": "366"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.Cl.ClCCl.Clc1c(-c2ccccc2)nnc2c1c(-c1ccccc1)nn2CCI.F[C@H]1CCNC1>>F[C@H]1CCN(CCn2nc(-c3ccccc3)c3c(Cl)c(-c4ccccc4)nnc32)C1",
        "output": "184"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)N.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cn1nnc(-c2ccc(F)cc2)c1C#Cc1ccc(C(=O)O)cn1.F[B-](F)(F)F>>CC(C)NC(=O)c1ccc(C#Cc2c(-c3ccc(F)cc3)nnn2C)nc1",
        "output": "674"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.Nc1ccc(C(=O)CBr)cc1>>CC(C)(C)CC1NC(C(=O)Nc2ccc(C(=O)CBr)cc2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F",
        "output": "563"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CC(C)=O.O=C1NC(=O)C(=Cc2ccc(C(=O)CCCc3ccccc3)cc2)S1.O=S(=O)(O)O.O=[Cr](=O)=O>>O=C1NC(=O)C(Cc2ccc(C(=O)CCCc3ccccc3)cc2)S1",
        "output": "762"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.Cl.Fc1ccc2c(c1)CCN2.O.O=C([O-])O.O=S(=O)(O)O.O=S(=O)([O-])[O-].[Ag+].[Ag+].[Na+]>>Fc1cc2c(cc1Br)NCC2",
        "output": "98"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc2nc(NC(=O)[C@H](CC3CCCC3)c3ccccc3)sc2n1.ClCCl.O=S(=O)(O)Cl>>COc1ccc2nc(NC(=O)[C@H](CC3CCCC3)c3ccc(S(=O)(=O)Cl)cc3)sc2n1",
        "output": "182"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNC(N)=NC(=O)c1cc2cccc(NCCCNC(=O)OC(C)(C)C)c2[nH]1.CO.Cl>>CNC(N)=NC(=O)c1cc2cccc(NCCCN)c2[nH]1",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Clc1cc(Cl)ncn1.O.O=P([O-])([O-])[O-].OB(O)c1ccc(C(F)(F)F)c(Cl)c1.[K+].[K+].[K+].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>FC(F)(F)c1ccc(-c2cc(Cl)ncn2)cc1Cl",
        "output": "884"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CO.Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CCC(=O)N1CCC(CN(C(=O)OC(C)(C)C)C2CC2)CC1.Cl>>Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CCC(=O)N1CCC(CNC2CC2)CC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O.O=C(O)c1ccccc1Nc1ccccc1[N+](=O)[O-].O=S(=O)(O)O.[Na+].[OH-]>>COC(=O)c1ccccc1Nc1ccccc1[N+](=O)[O-]",
        "output": "33"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CN(C)C=O.COC(C)(C)C.COc1ccc(CO)nc1Br.O.[Cl-].[Na+].c1c[nH]cn1>>COc1ccc(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)nc1Br",
        "output": "602"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cc(N2CCN(CCOc3ccccc3)C2=O)sc1C(=O)O.Cc1cc(N2CCN(Cc3ccc(F)cc3)C2=O)sc1C(=O)O.Cc1n[nH]c(C)c1CN.O.O=C(O)C(=O)O.O=C(O)C(=O)O>>Cc1cc(N2CCN(Cc3ccc(F)cc3)C2=O)sc1C(=O)NCc1c(C)n[nH]c1C",
        "output": "736"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C.ClC(Cl)Cl.O=S(Cl)Cl.O=c1[nH]c2ccc(Cl)cc2n1CCCO>>O=c1[nH]c2ccc(Cl)cc2n1CCCCl",
        "output": "96"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)CCOc1cccc(Nc2nccc(-c3c(-c4cccc(NC(=O)C(F)(F)F)c4)nn4ccccc34)n2)c1.[Li+].[OH-]>>CN(C)CCOc1cccc(Nc2nccc(-c3c(-c4cccc(N)c4)nn4ccccc34)n2)c1",
        "output": "491"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Cc1ccccc1O.O.O=C(CBr)N1CCC2(CC1)C(=O)Nc1ccccc12.O=C([O-])[O-].[K+].[K+]>>Cc1ccccc1OCC(=O)N1CCC2(CC1)C(=O)Nc1ccccc12",
        "output": "778"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.Nc1c(Br)c(C(=O)O)c(Br)c(C(=O)O)c1Br.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>O=C(Nc1c(Br)c(C(=O)O)c(Br)c(C(=O)O)c1Br)c1ccc([N+](=O)[O-])cc1",
        "output": "11"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.OCCc1cc(CO)ccc1Cl.[Mn+4].[O-2].[O-2]>>O=Cc1ccc(Cl)c(CCO)c1",
        "output": "179"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.Cc1cc(Nc2nc(C(=O)c3ccc(F)cc3)cc3ccccc23)nn1C(=O)OC(C)(C)C.Cl>>Cc1cc(Nc2nc(C(=O)c3ccc(F)cc3)cc3ccccc23)n[nH]1",
        "output": "896"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "N#Cc1ccccc1O[C@@H]1CC[C@@H](N)CC1.O=C(O)CCCc1nc2ccccc2c(=O)[nH]1>>N#Cc1ccccc1O[C@@H]1CC[C@@H](NC(=O)CCCc2nc3ccccc3c(=O)[nH]2)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1cc2c(OC(C)=O)c(OC)ccc2n1Cc1ccc(Cl)c(Cl)c1.C[O-].[Na+]>>COC(=O)c1cc2c(O)c(OC)ccc2n1Cc1ccc(Cl)c(Cl)c1",
        "output": "22"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COCc1noc(N2CCC([C@H]3C[C@H]3CCOc3cc(F)c(CC(=O)OC)c(F)c3)CC2)n1.Cl.O.[Li+].[OH-]>>COCc1noc(N2CCC([C@H]3C[C@H]3CCOc3cc(F)c(CC(=O)O)c(F)c3)CC2)n1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1=CC(=C(C#N)C(=O)O)CC(C)(C)C1.CCCCN.Cl.O=S(Cl)Cl>>CCCCNC(=O)C(C#N)=C1C=C(C)CC(C)(C)C1",
        "output": "549"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=Cc1ccc(OC)c(OC)c1.CCOCC.CC[SiH](CC)CC.c1ccccc1>>CCc1ccc(OC)c(OC)c1",
        "output": "555"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)Cc1csc(N)n1.O=S(=O)(Cl)c1cccc(Cl)c1>>CCOC(=O)Cc1csc(NS(=O)(=O)c2cccc(Cl)c2)n1",
        "output": "637"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.Cc1cccc2nc(C(C)N3C(=O)c4ccccc4C3=O)c(Br)c(=O)n12.Clc1cc[c-](P(c2ccccc2)c2ccccc2)c1Cl.O.O=C([O-])[O-].OB(O)c1ccccc1.[Fe+2].[K+].[K+].[Pd+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cccc2nc(C(C)N3C(=O)c4ccccc4C3=O)c(-c3ccccc3)c(=O)n12",
        "output": "871"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "B.CC(=O)O.CCOc1cc(C=O)ccc1Cl.CCOc1cc(CN2CCC(NC(=O)c3cccc4cc[nH]c34)CC2)ccc1Cl.Cc1cncc(C(=O)NC2CCNCC2)c1.ClCCCl.c1ccncc1>>CCOc1cc(CN2CCC(NC(=O)c3cncc(C)c3)CC2)ccc1Cl",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCc1cc(C(=O)OC)c(OC)nc1-c1ccc2c(c1)cc(C1CN(C(=O)OC(C)(C)C)CCN1C(=O)OCc1ccccc1)n2C.CO.[Pd]>>CCc1cc(C(=O)OC)c(OC)nc1-c1ccc2c(c1)cc(C1CN(C(=O)OC(C)(C)C)CCN1)n2C",
        "output": "428"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCC(N)c1nc(-c2ccc(F)cc2)c[nH]1.O=C1CCCCC1>>CCCCCCC(NC1CCCCC1)c1nc(-c2ccc(F)cc2)c[nH]1",
        "output": "236"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCI.O=C(NC[C@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1[C@@H](O)[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1>>CCN1CCC[C@H](CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2[C@@H](O)[C@@H](O)CN2C(=O)CC(c2ccccc2)(c2ccccc2)c2ccccc2)C1",
        "output": "184"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NC1(c2ccc(C(C)(C)N)o2)CC1.O.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)NC1(c2ccc(C(C)(C)NC(=O)OCc3ccccc3)o2)CC1",
        "output": "479"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1cccc([C@H](C)N=C=O)c1.c1nc(N2CCNCC2)c2sc(N3CCOCC3)cc2n1>>COc1cccc([C@H](C)NC(=O)N2CCN(c3ncnc4cc(N5CCOCC5)sc34)CC2)c1",
        "output": "583"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cl.NCCNC(=O)Nc1ccc(OCc2ccccc2)cc1>>NCCNC(=O)Nc1ccc(O)cc1",
        "output": "698"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)CC(O)CC(C)(C)O1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC1(C)CC(OS(C)(=O)=O)CC(C)(C)O1",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=C([C@H]1CCC=C[C@H]1c1ccccc1)N1CC(CN2CCC(c3ccccc3)CC2)C(c2ccccc2)C1.[Pd]>>O=C([C@H]1CCCC[C@H]1c1ccccc1)N1CC(CN2CCC(c3ccccc3)CC2)C(c2ccccc2)C1",
        "output": "143"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(F)c1cc(NC(=O)Nc2cccc(O)c2)on1.COc1cc2ncnc(Cl)c2cc1OCCCS(C)(=O)=O>>COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)F)no4)c3)c2cc1OCCCS(C)(=O)=O",
        "output": "890"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.Nc1cc(F)cc(F)c1.O=C(O)CN1C(=O)C(c2ccc(C(F)(F)F)cc2)=NC12CCCC2>>O=C(CN1C(=O)C(c2ccc(C(F)(F)F)cc2)=NC12CCCC2)Nc1cc(F)cc(F)c1",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)C[C@H](Cc1ccc(OCCc2ccc3c(n2)NCCC3)cc1)c1ccccc1.O.[Li+].[OH-]>>O=C(O)C[C@H](Cc1ccc(OCCc2ccc3c(n2)NCCC3)cc1)c1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Nc1c(C(=O)O)cc(F)cc1[N+](=O)[O-].[H][H].[Pd]>>Nc1cc(F)cc(C(=O)O)c1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.COCOc1cc(O)c2c(=O)cc(-c3ccc(OC)c(Cl)c3)oc2c1CC=C(C)C.ClCCl>>COc1ccc(-c2cc(=O)c3c(O)cc(O)c(CC=C(C)C)c3o2)cc1Cl",
        "output": "755"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.Cc1cccc(Nc2nc(N3CCCCC3CNC(=O)OC(C)(C)C)nc3c2C(=O)NC3)c1.Cl>>Cc1cccc(Nc2nc(N3CCCCC3CN)nc3c2C(=O)NC3)c1",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCl.O.O=C1CCC(=O)O1.[Al+3].[Cl-].[Cl-].[Cl-].c1ccc2c(c1)CCCC2>>O=C(O)CCC(=O)c1ccc2c(c1)CCCC2",
        "output": "345"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(O)C(=O)O.CC(C)NC(C)C.CS(C)=O.Cl.N[C@@H]1CC[C@@H](NC(=O)c2ccc(-c3cccc(F)c3)nc2)CC1.O=C(n1ccnc1)n1ccnc1>>CC(C)(O)C(=O)N[C@@H]1CC[C@@H](NC(=O)c2ccc(-c3cccc(F)c3)nc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Cl.ClCCN1CCOCC1.O=[N+]([O-])c1cn[nH]c1.[K+].[OH-]>>O=[N+]([O-])c1cnn(CCN2CCOCC2)c1",
        "output": "604"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)N(C)C.CS(=O)(=O)c1cnc(Cl)nc1.Cn1nc(OCCO)c(-c2ccc3c(c2)OCO3)c1NS(=O)(=O)c1ccc(C(C)(C)C)cc1.[H-].[Na+]>>Cn1nc(OCCOc2ncc(S(C)(=O)=O)cn2)c(-c2ccc3c(c2)OCO3)c1NS(=O)(=O)c1ccc(C(C)(C)C)cc1",
        "output": "37"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.C[C@@H](O)CSc1cccc(-c2cc3nc(Cl)nc(N4CCOCC4)c3s2)c1.O.O=S([O-])OO.[K+]>>C[C@@H](O)CS(=O)(=O)c1cccc(-c2cc3nc(Cl)nc(N4CCOCC4)c3s2)c1",
        "output": "730"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)CC(=O)N1CCC(c2ccc(NC(=O)OC(C)(C)C)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>CN(C)CC(=O)N1CCC(c2ccc(N)cc2)CC1",
        "output": "782"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)CC1CCCCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1.O.[Li+].[OH-]>>O=C(O)CC1CCCCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)NC(C)C.Cc1ccc(F)c(Br)c1.O=C=O.[Li]CCCC>>Cc1cc(Br)c(F)c(C(=O)O)c1",
        "output": "387"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.Clc1cc(Cl)c(Cl)c(Cl)c1Cl.O=S(=O)(O)O.O=[N+]([O-])O>>O=[N+]([O-])c1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl",
        "output": "21"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1O.Cc1ccc(S(=O)(=O)OCC2(C)COC2)cc1>>COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCC1(C)COC1",
        "output": "438"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1ccc(Oc2ccccc2C(=O)O)cc1.O=S(=O)(O)O>>COC(=O)c1ccccc1Oc1ccc(C)cc1",
        "output": "33"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.Fc1ccc2c(C3CCNCC3)noc2c1>>CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC(c2noc3cc(F)ccc23)CC1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.[N-]=[N+]=NCCCCCCCc1ccccc1.[Pd]>>NCCCCCCCc1ccccc1",
        "output": "89"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1C[C@H](CO)[C@@H](c2ccccc2)C1.CCN(C(C)C)C(C)C.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)N1C[C@H](C=O)[C@@H](c2ccccc2)C1",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCCC(=O)N1CCOCC1.CCN(CC)CCN1C(=O)C(O)(c2ccccc2)c2c1cc(I)cc2C(F)(F)F>>CCN(CC)CCN1C(=O)C(O)(c2ccccc2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F",
        "output": "664"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O.N#Cc1cnc(N2CCNCC2)s1>>CC(C)(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ncc(C#N)s2)CC1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CO.Cc1ccc(S(=O)(=O)O)cc1.O=C(Cc1ccccc1)N1CCC(Cn2ncc3cc(-c4cnn(C5CCCCO5)c4)ccc32)CC1>>O=C(Cc1ccccc1)N1CCC(Cn2ncc3cc(-c4cn[nH]c4)ccc32)CC1",
        "output": "689"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.ClC(Cl)Cl.N.N#CCc1csc2ccc(F)cc12.[Ni].c1ccsc1>>NCCc1csc2ccc(F)cc12",
        "output": "246"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1.CO.O.O.[Li]O>>O=C(O)CC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1CO.CCBr.[H-].[Na+]>>CCOC[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)OC(C)(C)C",
        "output": "95"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCCCCCCC.CCOC(C)=O.CN[C@@H]1CCCC[C@H]1NC.Cc1ccccc1.Ic1ccccc1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+].c1ccc2[nH]ccc2c1>>c1ccc(-n2ccc3ccccc32)cc1",
        "output": "267"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(CCN1CCOCC1)c1ccc(O)c(C(=O)Nc2cc(-c3ccccc3)ccc2C(=O)OC(C)(C)C)c1.O=C(O)C(F)(F)F>>CN(CCN1CCOCC1)c1ccc(O)c(C(=O)Nc2cc(-c3ccccc3)ccc2C(=O)O)c1",
        "output": "752"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.COC(=O)c1ccc(Cn2nccc2-c2ccc(OC)c(O[C@@H]3CCOC3)c2)cc1.Cl.O.[Na+].[OH-]>>COc1ccc(-c2ccnn2Cc2ccc(C(=O)O)cc2)cc1O[C@@H]1CCOC1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)NC1CCNC1.CN1CCCC1=O.O=C(O)c1cn(-c2ccccc2)c2cc(Cl)c(F)cc2c1=O>>CC(=O)NC1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3-c2ccccc2)C1",
        "output": "280"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCc1ccc(Nc2nc(OCc3ccccc3)ccc2[N+](=O)[O-])cc1.[Zn]>>CCc1ccc(Nc2nc(OCc3ccccc3)ccc2N)cc1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCCBr.CN(C)C=O.O.O=C([O-])[O-].Oc1ccc(Br)nc1.[Cs+].[Cs+]>>CC(C)(C)OC(=O)NCCOc1ccc(Br)nc1",
        "output": "608"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOc1ncc(-c2nc(-c3ccc4c(c3)CCN(C(=O)OC(C)(C)C)CC4)no2)cc1C#N.ClCCl.O=C(O)C(F)(F)F>>CCOc1ncc(-c2nc(-c3ccc4c(c3)CCNCC4)no2)cc1C#N",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.COc1ccc2cc(Br)cc(C#N)c2c1Br.Cl.Cl[Sn]Cl.O.O>>COc1ccc2cc(Br)cc(C#N)c2c1",
        "output": "350"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)c1cccc(S(=O)(=O)Nc2cccc(F)c2)c1.Cl.O.[Na+].[OH-]>>O=C(O)c1cccc(S(=O)(=O)Nc2cccc(F)c2)c1",
        "output": "5"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)CBr.CCCC[N+](CCCC)(CCCC)CCCC.COc1cc(C)c(S(=O)(=O)N2CCn3c(C)ccc3C2CO)c(C)c1.ClCCl.[Br-].[Na+].[OH-]>>COc1cc(C)c(S(=O)(=O)N2CCn3c(C)ccc3C2COCC(=O)OC(C)(C)C)c(C)c1",
        "output": "669"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCOCCc1ccc(OCC2CO2)cc1.CC(C)N.CO>>C=CCOCCc1ccc(OCC(O)CNC(C)C)cc1",
        "output": "16"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCSc1cccc(S(=O)(=O)c2ccc(C3CCN(C(=O)OC(C)(C)C)C3)c(OC)c2)c1.ClCCl.O=C(O)C(F)(F)F>>CCSc1cccc(S(=O)(=O)c2ccc(C3CCNC3)c(OC)c2)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc2c(ccn2Cc2ccc(F)cc2F)c1.[Na+].[OH-]>>O=C(O)c1ccc2c(ccn2Cc2ccc(F)cc2F)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCBr.CN(C)C=O.Oc1ccccc1Br.[H-].[Na+]>>C=CCOc1ccccc1Br",
        "output": "77"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C(O)(CC(C)(C)c1cc(F)ccc1OC)C(F)(F)F.CO.[K+].[OH-]>>COc1ccc(F)cc1C(C)(C)CC(O)(C(=O)O)C(F)(F)F",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(O)c(C=O)c1.Cc1cccnc1C(=N)NN>>Cc1ccc(O)c(-c2nc(-c3ncccc3C)n[nH]2)c1",
        "output": "994"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cc1cc(CN)no1.F[B-](F)(F)F.O.O=C(O)c1ccnc(-n2cnn(Cc3ccc(F)c(F)c3)c2=O)c1.On1nnc2ccccc21>>Cc1cc(CNC(=O)c2ccnc(-n3cnn(Cc4ccc(F)c(F)c4)c3=O)c2)no1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.COC(=O)c1ccc2nc(-c3ccccc3)c(C)nc2c1.O.[Li+].[OH-]>>Cc1nc2cc(C(=O)O)ccc2nc1-c1ccccc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C(=O)Cc1cc(F)c(OCC[C@@H]2C[C@@H]2C2CCN(C(=O)OCc3ccccc3)CC2)cc1F.CO.[Pd]>>CN(C)C(=O)Cc1cc(F)c(OCC[C@@H]2C[C@@H]2C2CCNCC2)cc1F",
        "output": "428"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "N#Cc1ccc(CCC(=O)O)cc1F.O=C1OCc2cc(SC3CC[NH2+]CC3)ccc21.[Cl-]>>N#Cc1ccc(CCC(=O)N2CCC(Sc3ccc4c(c3)COC4=O)CC2)cc1F",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)c1ccccc1OCc1ccccc1.CCOC(=O)C(=O)OCC.[H-].[Na+]>>CCOC(=O)C(=O)CC(=O)c1ccccc1OCc1ccccc1",
        "output": "526"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCC(CNC(=O)OC(C)(C)C)N1C(=O)c2ccccc2C1=O.CN>>CCOCC(N)CNC(=O)OC(C)(C)C",
        "output": "242"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.Cc1cc(Cl)nc(N)n1.Cc1cc(N)c2cc(NC(=O)CCN)ccc2n1>>Cc1cc(NCCC(=O)Nc2ccc3nc(C)cc(N)c3c2)nc(N)n1",
        "output": "166"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCNC.COc1ccc(-n2nc(C(=O)O)cc2-c2cnc(NC(=O)OC(C)(C)C)cn2)cn1>>CCN(C)C(=O)c1cc(-c2cnc(NC(=O)OC(C)(C)C)cn2)n(-c2ccc(OC)nc2)n1",
        "output": "663"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cn1ccc(N)n1.F[P-](F)(F)(F)(F)F.O=C1C(=O)N(C(CC2CCCC2)C(=O)O)c2ccc(Cl)cc21>>Cn1ccc(NC(=O)C(CC2CCCC2)N2C(=O)C(=O)c3cc(Cl)ccc32)n1",
        "output": "795"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc2c(cc1OC)C(Cc1ccc(OC)c(OCc3ccccc3)c1)NCC2.NCc1ccccc1.O=C(Br)CBr>>COc1cc2c(cc1OC)C(Cc1ccc(OC)c(OCc3ccccc3)c1)N(CC(=O)NCc1ccccc1)CC2",
        "output": "946"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCC(=O)c1ccc2c(c1)S(=O)C=N2.O=C(c1ccccc1)c1ccc2c(c1)S(=O)C=N2>>CCCCC(O)c1ccc2c(c1)S(=O)C=N2",
        "output": "24"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)N.CN(C)C=O.O.O=C(O)c1cccc2cn[nH]c12.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)NC(=O)c1cccc2cn[nH]c12",
        "output": "674"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O.O=C(O)Cc1cc(Cl)ccc1F.[Al+3].[H-].[H-].[H-].[H-].[K+].[Li+].[OH-]>>OCCc1cc(Cl)ccc1F",
        "output": "231"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CI.CN(C)C=O.COC(=O)c1c[nH]c2ccccc12.O.[H-].[Na+]>>COC(=O)c1cn(C)c2ccccc12",
        "output": "191"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCN(C(C)C)C(C)C.CNC.Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(Cl)c4ccccc4n3)cc2)n1.[Cs+].[F-].[I-]>>CN(C)c1cc(COc2ccc(-c3nn(C)cc3-c3ccncc3)cc2)nc2ccccc12",
        "output": "398"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCCCBr.CCC(C)=O.CCCc1c(O)ccc2c(-c3ccccc3)coc12.O=C([O-])[O-].[K+].[K+]>>CCCc1c(OCCCBr)ccc2c(-c3ccccc3)coc12",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.ClCCl.NC[C@H]1CC[C@@H](c2ccccc2)CC1.O=C(Cl)c1ccc(Cl)cc1>>O=C(NC[C@@H]1CC[C@H](c2ccccc2)CC1)c1ccc(Cl)cc1",
        "output": "271"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.O=C(NCCCl)c1ccco1.O=C1NCN(c2ccccc2)C12CCNCC2.[I-].[K+]>>O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1ccco1",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.N#Cc1ncc(Br)cc1[N+](=O)[O-].[Fe]>>N#Cc1ncc(Br)cc1N",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.COC(=O)Nc1c(O)cccc1F.Cc1ccc(S(=O)(=O)O)cc1.ClC(Cl)Cl.O.O=C1CCC(=O)N1Cl>>COC(=O)Nc1c(O)ccc(Cl)c1F",
        "output": "121"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cc2c(Oc3ccc(F)cc3[N+](=O)[O-])cccc2[nH]1.CCOC(C)=O.[Pd]>>CCOC(=O)c1cc2c(Oc3ccc(F)cc3N)cccc2[nH]1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC(CO)CC1.Oc1ccc(Cl)nc1>>CC(C)(C)OC(=O)N1CCC(COc2ccc(Cl)nc2)CC1",
        "output": "547"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCC.CCOC(C)=O.CN(C)C=O.N#Cc1ccc(C(F)(F)F)cc1F.Nc1ccccc1S.[H-].[Na+]>>N#Cc1ccc(C(F)(F)F)cc1Sc1ccccc1N",
        "output": "675"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CNC1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cc[nH]c1>>O=C(c1cc[nH]c1)N1CCC1",
        "output": "256"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)OC(C)C.CC1(C)CC2(CCCN(C3CCN(C(=O)c4cc(Cl)nc(N5CCC(O)CC5)c4)CC3)C2)C(=O)O1.OB(O)c1ccccc1>>CC1(C)CC2(CCCN(C3CCN(C(=O)c4cc(-c5ccccc5)nc(N5CCC(O)CC5)c4)CC3)C2)C(=O)O1",
        "output": "865"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Fc1cc(Cl)ccc1I.Sc1ccccc1Br>>Fc1cc(Cl)ccc1Sc1ccccc1Br",
        "output": "565"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "NCC(c1cnc(C(F)(F)F)nc1)N1CCOCC1.O=C(O)c1cccc(F)c1Cl>>O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCOCC1)c1cccc(F)c1Cl",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)CC1OB(O)c2cc(Oc3cccc(OCc4ccccc4)c3)cc(C)c21.[Pd]>>CCOC(=O)CC1OB(O)c2cc(Oc3cccc(O)c3)cc(C)c21",
        "output": "23"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCC.CCOC(C)=O.Cc1cccc(-c2cnoc2)c1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>BrCc1cccc(-c2cnoc2)c1",
        "output": "29"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CNc2nc(Cl)ncc2[N+](=O)[O-])CC1.CCN(C(C)C)C(C)C.Cc1c(Br)cccc1CN.Cl.ClCCl>>Cc1c(Br)cccc1CNc1ncc([N+](=O)[O-])c(NC[C@@H]2CC[C@@H](NC(=O)OC(C)(C)C)CC2)n1",
        "output": "364"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COC(=O)C(C)(C)Cc1c(SC(C)(C)C)c2cc(O)ccc2n1Cc1ccc(Cl)cc1.Cl.Cl.ClCc1ccc2ccccc2n1.O.O=C([O-])[O-].O=C([O-])[O-].[Cs+].[Cs+].[K+].[K+]>>COC(=O)C(C)(C)Cc1c(SC(C)(C)C)c2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Cl)cc1",
        "output": "616"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O.O=C(Nc1ccc(F)cc1)c1c(Cl)cccc1[N+](=O)[O-].O=C[O-].[Fe].[NH4+]>>Nc1cccc(Cl)c1C(=O)Nc1ccc(F)cc1",
        "output": "486"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.OCCCC1CCN(Cc2ccccc2)CC1>>O=CCCC1CCN(Cc2ccccc2)CC1",
        "output": "142"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.ClCCCl.Nc1ccc2c(c1)c(-c1nc3cc(N4CCOCC4)ccc3[nH]1)nn2C1CCCCO1.O=C(O)C1CC1(F)F.O=C([O-])O.On1nnc2ccccc21.[Na+]>>O=C(Nc1ccc2c(c1)c(-c1nc3cc(N4CCOCC4)ccc3[nH]1)nn2C1CCCCO1)C1CC1(F)F",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccc(F)cc1Nc1cc(F)cc(F)c1.[Pd]>>Nc1ccc(F)cc1Nc1cc(F)cc(F)c1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCOC(C)=O.Cc1cccc2cnc(Cl)nc12.Cl.Nc1ccc2c(CO)n[nH]c2c1>>Cc1cccc2cnc(Nc3ccc4c(CO)n[nH]c4c3)nc12",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1cccc(NC(=O)c2ccc(N3CCN(c4ccc(C(=O)O)cc4)CC3)c(F)c2)c1.CC(C)(C)c1cccc(NC(=O)c2ccc(N3CCNCC3)nc2)c1.O=C(O)c1ccc(Cl)nc1>>CC(C)(C)c1cccc(NC(=O)c2ccc(N3CCN(c4ccc(C(=O)O)cn4)CC3)nc2)c1",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc2c(Nc3ccc4[nH]c(C)c(C)c4c3)ncnc2cc1O.O=S1(=O)CCN(CCCO)CC1>>COc1cc2c(Nc3ccc4[nH]c(C)c(C)c4c3)ncnc2cc1OCCCN1CCS(=O)(=O)CC1",
        "output": "478"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.COc1ccc2cc(-c3ccccc3Cl)n(Cc3cccc(NC(=O)C(C)(C)C)n3)c2c1.ClCCl>>CC(C)(C)C(=O)Nc1cccc(Cn2c(-c3ccccc3Cl)cc3ccc(O)cc32)n1",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cccc(C)c1NC(=O)CN1CCN([C@@H]2CCN[C@@H](Cc3ccccc3)C2)CC1.ClCCl.O=C=Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>Cc1cccc(C)c1NC(=O)CN1CCN([C@@H]2CCN(C(=O)Nc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](Cc3ccccc3)C2)CC1",
        "output": "323"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC1CCC(CBr)CC1.C[Si](C)(C)I.ClC(Cl)Cl>>OC1CCC(CBr)CC1",
        "output": "423"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Fc1ccc(-c2c(-c3cccc(Cl)n3)nn3ccccc23)cc1.[H-].[Na+]>>CCOc1cccc(-c2nn3ccccc3c2-c2ccc(F)cc2)n1",
        "output": "433"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1ccccc1.Clc1nccc2ccccc12.O=C([O-])[O-].OB(O)c1ccccc1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>c1ccc(-c2nccc3ccccc23)cc1",
        "output": "865"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)NC(C)C.CCCCCC.CCOC(C)=O.CN(C)C=O.C[Si](C)(C)c1c(Br)ccc(F)c1F.O>>C[Si](C)(C)c1c(Br)cc(C=O)c(F)c1F",
        "output": "239"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)c1cc(C(F)(F)F)ccc1COc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.COC(=O)Cc1ccc(Br)cc1>>COC(=O)Cc1ccc(-c2ccc(OCc3ccc(C(F)(F)F)cc3C(=O)OC(C)(C)C)cc2)cc1",
        "output": "933"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCCNCC1.CC(C)(C)[O-].COCCOC.COc1ccc(Br)c(OC)c1.[K+]>>COc1ccc(N2CCCN(C(=O)OC(C)(C)C)CC2)c(OC)c1",
        "output": "294"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Cl.O=C(NCCCNc1nc(Cl)ncc1Br)Nc1cccc([N+](=O)[O-])c1.[Na+].[OH-]>>Nc1cccc(NC(=O)NCCCNc2nc(Cl)ncc2Br)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cc1nn(-c2ccc([N+](=O)[O-])cc2F)c(=O)n1C(F)F.O=[Pt].[H][H]>>Cc1nn(-c2ccc(N)cc2F)c(=O)n1C(F)F",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)O.COC(=O)C1CNCCN1C(=O)OC(C)(C)C.Clc1cc(-c2ccc(Cl)c(Cl)c2)ncn1>>COC(=O)C1CN(c2cc(-c3ccc(Cl)c(Cl)c3)ncn2)CCN1C(=O)OC(C)(C)C",
        "output": "162"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C(=O)O)C(NC(=O)c1ccc(C#N)cc1)c1cccc(Cl)c1.CCN(CC)CC.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.COC(=O)CC1CCNCC1.ClCCl.F[P-](F)(F)(F)(F)F>>COC(=O)CC1CCN(C(=O)C(C)(C)C(NC(=O)c2ccc(C#N)cc2)c2cccc(Cl)c2)CC1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COc1cc(CC(=O)O)ccc1OC(C)=O.O.O=C1CCC(=O)N1Cl>>COc1cc(CC(=O)O)c(Cl)cc1OC(C)=O",
        "output": "121"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)N(C)C.Cc1cc(OC(F)F)cnc1Cl.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[C-]#N.[C-]#N.[Fe+2].[Pd].[Pd].[Zn+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cc(OC(F)F)cnc1C#N",
        "output": "726"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CN(C)C=O.CN(C)c1ccncc1.Cc1n[nH]c2nc(-c3ccc(O)cc3F)c(C#N)c(C(=O)O)c12.Cl.NCCCN.On1nnc2ccccc21>>Cc1n[nH]c2nc(-c3ccc(O)cc3F)c(C#N)c(C(=O)N3CCN(C(=O)OC(C)(C)C)CC3)c12",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C.CC(O)(C(=O)O)C(F)(F)F.CCCCCC.Nc1ccc(C(=O)c2cccc(F)c2)cc1.O.O=S(Cl)Cl>>CC(O)(C(=O)Nc1ccc(C(=O)c2cccc(F)c2)cc1)C(F)(F)F",
        "output": "365"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)C(=O)[O-].CC(=O)N[C@@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O.CC(=O)N[C@@H]1[C@@H](O)CC(O)(C(=O)[O-])O[C@H]1[C@H](O)[C@H](O)CO.O.[Na+]>>CC(=O)N[C@@H]1[C@@H](O)CC(O)(C(=O)O)O[C@H]1[C@H](O)[C@H](O)CO",
        "output": "151"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.NC(=O)c1sc2nc(NC3CC3)nc(-c3cccc(N)c3)c2c1N.O=C=Nc1ccc(C(F)(F)F)cc1>>NC(=O)c1sc2nc(NC3CC3)nc(-c3cccc(NC(=O)Nc4ccc(C(F)(F)F)cc4)c3)c2c1N",
        "output": "473"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC(Cc1ccccc1Cl)C(=O)O.CCOC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1N>>CCOC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1NC(=O)C(Cc1ccccc1Cl)NC(=O)OC(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(C)=O.C[C@H](N)c1cc2cc(Cl)ccc2[nH]c1=O.Cl.Fc1nccc(I)c1F.O=C([O-])[O-].[K+].[K+]>>C[C@H](Nc1nccc(I)c1F)c1cc2cc(Cl)ccc2[nH]c1=O",
        "output": "810"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)CCCCCCCn1c(-c2ccccc2)nc(-c2ccc(OC)cc2)c1-c1ccc(OC)cc1.[Na+].[OH-]>>COc1ccc(-c2nc(-c3ccccc3)n(CCCCCCCC(=O)O)c2-c2ccc(OC)cc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CCN(C(C)C)C(C)C.Cl.ClCCl.F[P-](F)(F)(F)(F)F.N[C@@H](Cc1ccc(F)c(F)c1)CN1C(=O)c2ccccc2C1=O.O=C(O)c1ncc[nH]1>>O=C(N[C@@H](Cc1ccc(F)c(F)c1)CN1C(=O)c2ccccc2C1=O)c1ncc[nH]1",
        "output": "951"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)O.CCOc1cc(N2CCC(N3CCN(S(C)(=O)=O)CC3)CC2)ccc1N.COc1ccc(-c2nc3ccccn3c2-c2ccnc(Cl)n2)cc1C(=O)Nc1c(F)cccc1F.Cc1ccc(S(=O)(=O)O)cc1>>CCOc1cc(N2CCC(N3CCN(S(C)(=O)=O)CC3)CC2)ccc1Nc1nccc(-c2c(-c3ccc(OC)c(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1",
        "output": "808"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.COC(=O)c1ccc(Oc2ccc(CC(=O)OC(C)(C)C)cc2CN)cc1.CS(=O)(=O)Cl.Cl.ClCCl.c1ccncc1>>COC(=O)c1ccc(Oc2ccc(CC(=O)OC(C)(C)C)cc2CNS(C)(=O)=O)cc1",
        "output": "742"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC#N.CCN(C(C)C)C(C)C.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1nnc2ccc3c(cc(C(=O)O)n3Cc3cccc(Cl)c3)n12.F[P-](F)(F)(F)(F)F>>CNC(=O)c1cc2c(ccc3nnc(C)n32)n1Cc1cccc(Cl)c1",
        "output": "137"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.COc1ccc(N2CCCn3c2nc2c(Cl)ccc(C(O)C(F)(F)F)c23)c(Cl)c1.O.[H-].[Na+]>>COc1ccc(N2CCCn3c2nc2c(Cl)ccc(C(OC)C(F)(F)F)c23)c(Cl)c1",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.Cl.N#Cc1cc(C(=O)c2cc(F)cc(F)c2)ccc1F.NN.O>>Nc1n[nH]c2ccc(C(=O)c3cc(F)cc(F)c3)cc12",
        "output": "945"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)Cc1cccc(C)c1.ClC(Cl)(Cl)Cl.ClCCl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>CCOC(=O)Cc1cccc(CBr)c1",
        "output": "29"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.CN(C)c1ccncc1.NCCc1ccccn1.c1ccncc1>>CC(=O)NCCc1ccccn1",
        "output": "339"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.CS(=O)(=O)Nc1ccc2c(c1)C(O)c1cc(-c3ccccc3)cnc1C=C2>>CC(=O)OC1c2cc(NS(C)(=O)=O)ccc2C=Cc2ncc(-c3ccccc3)cc21",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCO.Cl.N#Cc1cccc(I)c1.NO.[Cl-].[NH4+]>>NC(=NO)c1cccc(I)c1",
        "output": "400"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.COc1ccc2c(c1)C(=O)CCC2>>O=C1CCCc2ccc(O)cc21",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.CC(C)(C)c1cc(NC(=O)Oc2ccccc2)n(-c2ccccc2)n1.CCN(C(C)C)C(C)C.COCCN1C[C@@H](c2ccccc2)[C@H](N)C1.Cl.Cl>>COCCN1C[C@@H](c2ccccc2)[C@H](NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccccc2)C1",
        "output": "488"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CN1CCC(=O)CC1.O=[N+]([O-])CCc1ccc2[nH]ccc2c1.[NH4+].[OH-]>>CN1CC=C(c2c[nH]c3ccc(CC[N+](=O)[O-])cc23)CC1",
        "output": "607"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1ccn2ccccc12.[Na+].[OH-]>>O=C(O)c1ccn2ccccc12",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN.O.O=C([O-])[O-].O=C1CCN(C(=O)OCc2ccccc2)CC1.[Na+].[Na+].[Na+]>>CCNC1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "236"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCOC(C)=O.C[C@@H]1CC[C@H](C(=O)Nc2ccccc2)CN1.Nc1nc(Cl)cc(Cl)n1.Nc1nc(Cl)cc(Cl)n1.O.O=C([O-])O.[Na+]>>C[C@@H]1CC[C@H](C(=O)Nc2ccccc2)CN1c1cc(Cl)nc(N)n1",
        "output": "162"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1N.CCN(C(C)C)C(C)C.CCOC(C)=O.O=C(Nc1ccc2cnccc2n1)c1csc2cnc(Cl)nc12>>CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1Nc1ncc2scc(C(=O)Nc3ccc4cnccc4n3)c2n1",
        "output": "544"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCC2=NCCCN2CC1.CC#N.CI.O=C(O)C(O)(c1ccccc1)c1ccccc1>>COC(=O)C(O)(c1ccccc1)c1ccccc1",
        "output": "415"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CS(=O)(=O)OC[C@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1O.[N-]=[N+]=[N-].[Na+]>>[N-]=[N+]=NC[C@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1O",
        "output": "322"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "N=C(NO)c1cccc(F)c1.O=C(O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)N2CCOCC2)C1>>O=C(N1CCOCC1)N1CC(c2ccc(OC(F)(F)F)cc2)CC(c2nc(-c3cccc(F)c3)no2)C1",
        "output": "895"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Nc1cccc2ccc(O)cc12.CN(C)c1ccncc1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(=O)Nc1cccc2ccc(OS(=O)(=O)C(F)(F)F)cc12",
        "output": "731"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc3c(c12)CCC(C(=O)O)C3.CNCC(O)CO>>CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc3c(c12)CCC(C(=O)N(C)CC(O)CO)C3",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)P(=O)(N(C)C)N(C)C.COCCOC.COc1ccc(O)cc1.FC(F)(F)c1cccc(Cl)n1.O.[K+].[OH-]>>COc1ccc(Oc2cccc(C(F)(F)F)n2)cc1",
        "output": "516"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.N#Cc1ccc(F)cc1C(F)(F)F.[Ni]>>NCc1ccc(F)cc1C(F)(F)F",
        "output": "175"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N(C)C.CCCCCCCCCCCCCCCCNc1ccc(C(=O)O)cc1.COCCOC.ClCCl.NS(=O)(=O)c1ccccc1.O=S(Cl)Cl.[H-].[Na+]>>CCCCCCCCCCCCCCCCNc1ccc(C(=O)NS(=O)(=O)c2ccccc2)cc1",
        "output": "579"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CCc1nc(/C=C/c2cn(-c3ccccc3)nc2OCc2ccc(OCc3nc(-c4cccc(N)c4)oc3C)c(OC)c2)cs1.CS(=O)(=O)Cl.O=C([O-])O.[Na+]>>CCc1nc(/C=C/c2cn(-c3ccccc3)nc2OCc2ccc(OCc3nc(-c4cccc(NS(C)(=O)=O)c4)oc3C)c(OC)c2)cs1",
        "output": "194"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1ccc2[nH]ccc2c1.CN(C)C=O.Cc1ccc(CBr)cc1.[H-].[Na+]>>Cc1ccc(Cn2ccc3cc(Br)ccc32)cc1",
        "output": "528"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCNC(=O)Nc1ccc(Oc2ccnc3cc(O)c(OC)cc23)cc1Cl.CN(C)C=O.Cc1ccc(S(=O)(=O)OCCn2ccnc2)cc1.O.O=C([O-])[O-].[K+].[K+]>>CCCNC(=O)Nc1ccc(Oc2ccnc3cc(OCCn4ccnc4)c(OC)cc23)cc1Cl",
        "output": "438"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.COc1cc2nccc(Cl)c2cc1OCCCN1CCOCC1.O=[N+]([O-])c1ccc(O)c(F)c1.c1ccc(Oc2ccccc2)cc1>>COc1cc2nccc(Oc3ccc([N+](=O)[O-])cc3F)c2cc1OCCCN1CCOCC1",
        "output": "351"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1cccc(Br)c1.O=S(=O)(O)O.O=[N+]([O-])[O-].[NH4+]>>O=[N+]([O-])c1ccc(Br)cc1Br",
        "output": "103"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NC[C@H]1CN(c2ccc(C3=NNC(=O)CS3)c(F)c2)C(=O)O1.O=Cc1ccc(C=CC(=O)O)cc1>>O=Cc1ccc(C=CC(=O)NC[C@H]2CN(c3ccc(C4=NNC(=O)CS4)c(F)c3)C(=O)O2)cc1",
        "output": "549"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCC.CN(C)C=O.Cc1ccc(S(=O)(=O)OCCOCC(F)F)cc1.O=C([O-])[O-].OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O.[Cs+].[Cs+]>>OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(OCCOCC(F)F)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O",
        "output": "438"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCNc1nc(N)nc(C)c1Cc1ccc(O)cc1OC.CN(C)C=O.COC(=O)CBr>>CCCCCNc1nc(N)nc(C)c1Cc1ccc(OCC(=O)OC)cc1OC",
        "output": "557"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)Oc2ccc(CC(=O)NCc3ccc(Cl)cc3)cc2C(N)C1O.CN1CCCCC1.Cc1cccc(S(=O)(=O)Cl)c1.ClCCl>>Cc1cccc(S(=O)(=O)NC2c3cc(CC(=O)NCc4ccc(Cl)cc4)ccc3OC(C)(C)C2O)c1",
        "output": "530"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.Cc1ccc2cc(S(N)(=O)=O)ccc2n1.O=[Se]=O>>NS(=O)(=O)c1ccc2nc(C=O)ccc2c1",
        "output": "619"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1cc(-c2cn[nH]c2)ccc1OCc1ccc(F)cc1.COCCBr.O=C([O-])[O-].[K+].[K+]>>COCCn1cc(-c2ccc(OCc3ccc(F)cc3)c(C(=O)OC)c2)cn1",
        "output": "577"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.COC(=O)c1cc(C2CC2)ccc1Nc1ccc(F)c([N+](=O)[O-])c1.Nc1ccccc1.O>>COC(=O)c1cc(C2CC2)ccc1Nc1ccc(Nc2ccccc2)c([N+](=O)[O-])c1",
        "output": "609"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NCCCOc1c(Cl)cc(OCc2ccccc2)cc1Cl.CCO.CCOC(C)=O.[H][H].[Pd]>>CC(C)(C)OC(=O)NCCCOc1c(Cl)cc(O)cc1Cl",
        "output": "23"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(=O)Cl.O=C1Cc2ccccc2N1>>CCC(=O)c1ccc2c(c1)CC(=O)N2",
        "output": "31"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)N(C(=S)NC(=O)c1ccccc1)c1ccc2c(c1)OCO2.O.[Na+].[OH-]>>CC(C)N(C(N)=S)c1ccc2c(c1)OCO2",
        "output": "80"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc2[nH]ncc2cc1Nc1ncnc2[nH]c(C(=O)O)c(Br)c12.C[C@@H]1COCCN1>>COc1cc2[nH]ncc2cc1Nc1ncnc2[nH]c(C(=O)N3CCOC[C@H]3C)c(Br)c12",
        "output": "605"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=O.CO.COCCN[C@@H]1CCc2nc(NC(=O)c3cccc(Cn4cc(-c5ccc(C#N)cc5)nn4)c3)sc2C1.[BH3-]C#N.[Na+]>>COCCN(C)[C@@H]1CCc2nc(NC(=O)c3cccc(Cn4cc(-c5ccc(C#N)cc5)nn4)c3)sc2C1",
        "output": "217"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.COc1ccc2[nH]c3c(c2c1)CSc1ncccc1-3.[H-].[Na+]>>COc1ccc2c(c1)c1c(n2C)-c2cccnc2SC1",
        "output": "191"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cl.NCc1cccc([N+](=O)[O-])c1.[Na+].[OH-]>>CC(C)(C)OC(=O)NCc1cccc([N+](=O)[O-])c1",
        "output": "686"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CN(C)C=O.Cc1ccccc1.N#CCCCBr.O.O=C1Nc2ccccc2C1(O)c1cccc(Cl)c1.[H-].[Na+]>>N#CCCCN1C(=O)C(O)(c2cccc(Cl)c2)c2ccccc21",
        "output": "367"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cncnc1Nc1ccc(C(F)(F)F)cc1.CO.O.[K+].[OH-]>>O=C(O)c1cncnc1Nc1ccc(C(F)(F)F)cc1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#Cc1cc(Cl)ccc1OCC(=O)OC(C)(C)C.CCCc1ccc(S(C)(=O)=O)cc1I>>CCCc1ccc(S(C)(=O)=O)cc1C#Cc1cc(Cl)ccc1OCC(=O)OC(C)(C)C",
        "output": "664"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cnn(Cc2ccccc2)c1C.Cl.O.O.[Li+].[OH-]>>Cc1c(C(=O)O)cnn1Cc1ccccc1",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCCCCCCC(=O)Cl.CCNCCCN(C)C.ClCCl>>CCCCCCCCCCCCCCCC(=O)N(CC)CCCN(C)C",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.COC(=O)CCc1cnoc1-c1ccc(OC)cc1.Cl.[H-]>>COc1ccc(-c2oncc2CCCO)cc1",
        "output": "343"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1cn(-c2cc(C(=O)Nc3cc(C(C)(C)C)cc(S(=O)(=O)NC)c3OC)ccc2C)nn1.CO.Cl.O.[Li+].[OH-]>>CNS(=O)(=O)c1cc(C(C)(C)C)cc(NC(=O)c2ccc(C)c(-n3cc(C(=O)O)nn3)c2)c1OC",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)CC1OB(O)c2cc(O)cc(CC)c21.Cl.O.[Li+].[OH-]>>CCc1cc(O)cc2c1C(CC(=O)O)OB2O",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(N)CO.CC(C)O.Clc1nc(-c2ccccc2)nc2ccccc12>>CC(C)(CO)Nc1nc(-c2ccccc2)nc2ccccc12",
        "output": "110"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOn1cnc2cnc3ccccc3c21.ClCCl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.[Na+]>>CCOn1cnc2c[n+]([O-])c3ccccc3c21",
        "output": "820"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.O=C(Cc1ccncc1)c1ccc(OCc2ccccc2)cc1>>O=C(Cc1ccncc1)c1ccc(O)cc1",
        "output": "23"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(S)CN.CCN(CC)CC.CCOCC.CN(C)C=O.Cl.Cl.Cl.ClCCl.O=C(Cl)c1cccnc1>>CC(C)(S)CNC(=O)c1cccnc1",
        "output": "353"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)C(=O)Cl.CCN(CC)CC.CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CCNCC3)n(C)c2n1.ClCCl>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CCN(C(=O)C(C)C)CC3)n(C)c2n1",
        "output": "125"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)CCc1ccc(OCCc2nc(-c3ccccc3)oc2C)c2c1CN(C(=O)OC(C)(C)C)C2.[Na+].[OH-]>>Cc1oc(-c2ccccc2)nc1CCOc1ccc(CCC(=O)O)c2c1CN(C(=O)OC(C)(C)C)C2",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)C1(NC(=O)c2cccc(C)c2OC2CCC2)Cc2cc(F)c(F)cc2C1.O.[K+].[OH-]>>Cc1cccc(C(=O)NC2(C(=O)O)Cc3cc(F)c(F)cc3C2)c1OC1CCC1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)Cc1cccc(Br)c1.Cc1ccccc1.O=C([O-])[O-].O=Cc1cccc(B(O)O)c1.[K+].[K+]>>COC(=O)Cc1cccc(-c2cccc(C=O)c2)c1",
        "output": "837"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1cc(Br)ccc1OCc1ccccc1.CCOC(=O)c1cc(C(F)(F)F)[nH]n1.CN(C)C=O.Cl.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cc(C(F)(F)F)n(Cc2cc(Br)ccc2OCc2ccccc2)n1",
        "output": "635"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccc(Br)cc1.C1CCOC1.CN1CCCN(C)C1=O.COC(=O)Cc1c(C)[nH]c2ccc(OC)cc12.C[Si](C)(C)[N-][Si](C)(C)C.Cl.[K+]>>COC(=O)Cc1c(C)n(Cc2ccc(Br)cc2)c2ccc(OC)cc12",
        "output": "528"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCc1cc(C(O)(C(F)(F)F)C(F)(F)F)ccc1O.O=S(=O)(O)O.O=[N+]([O-])O>>CCCc1cc(C(O)(C(F)(F)F)C(F)(F)F)cc([N+](=O)[O-])c1O",
        "output": "21"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cl.O=C1c2cc(N3CCNCC3)ccc2CN1C1CCCCC1>>CCOC(=O)N1CCN(c2ccc3c(c2)C(=O)N(C2CCCCC2)C3)CC1",
        "output": "219"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CN1CCOCC1.CN[C@H](CN1CCCC1)C(C)(C)C.O=C(Cl)c1ccc(Cl)c(Cl)c1>>CN(C(=O)c1ccc(Cl)c(Cl)c1)[C@H](CN1CCCC1)C(C)(C)C",
        "output": "201"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCCCC1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCCn1cc(Br)ccc1=O.CCOC(C)=O.CN(C)C=O.Cl[Pd]Cl.O.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCCn1cc(B2OC(C)(C)C(C)(C)O2)ccc1=O",
        "output": "943"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.CC(=O)C(C)(CCl)CCl>>CC(CCl)(CCl)C(=O)CBr",
        "output": "173"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#CCCO.CCN(CC)CC.CN(C)C=O.CN(C)CCOc1ccc(-c2cc3c(Br)cccc3c(=O)[nH]2)cc1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>CN(C)CCOc1ccc(-c2cc3c(C#CCCO)cccc3c(=O)[nH]2)cc1",
        "output": "659"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)NC1CCNCC1.CCN(C(C)C)C(C)C.O=c1cc(OCc2ccccc2F)ccn1CCc1ccc(CBr)cc1>>CC(=O)NC1CCN(Cc2ccc(CCn3ccc(OCc4ccccc4F)cc3=O)cc2)CC1",
        "output": "248"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Fc1ccc(OCc2cn3cc(Br)cnc3n2)cc1.OB(O)c1ccc(F)cc1O>>Oc1cc(F)ccc1-c1cnc2nc(COc3ccc(F)cc3)cn2c1",
        "output": "871"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.ClCC1CO1.O=c1cc(-c2cc(OCc3ccccc3)cc(OCc3ccccc3)c2)oc2cc(O)ccc12.[H-].[Na+]>>O=c1cc(-c2cc(OCc3ccccc3)cc(OCc3ccccc3)c2)oc2cc(OCC3CO3)ccc12",
        "output": "15"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NCC1(O)CCOCC1.O.O=[N+]([O-])c1cnc2ccccc2c1Cl>>O=[N+]([O-])c1cnc2ccccc2c1NCC1(O)CCOCC1",
        "output": "78"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)[C@@H]1C[C@@H](Nc2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)c(F)c2)C1.Cl.[Na+].[OH-]>>O=C(O)[C@@H]1C[C@@H](Nc2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)c(F)c2)C1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)=O.CCOC[C@H]1Cc2ccccc2CN1Cc1c(CC)nn(-c2c(C)cc(Br)cc2C)c1CC.[Li]CCCC>>CCOC[C@H]1Cc2ccccc2CN1Cc1c(CC)nn(-c2c(C)cc(C(C)(C)O)cc2C)c1CC",
        "output": "321"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C[C@@H]1NC[C@H](c2ccccc2)NC1=O.CC(C)C[C@H]1CN(C(=O)[C@@H]2C[C@H]2c2ccccc2)[C@@H](CC(C)C)C(=O)N1.O=C(O)[C@@H]1C[C@H]1c1ccc(F)cc1F>>CC(C)C[C@H]1C(=O)N[C@@H](c2ccccc2)CN1C(=O)[C@@H]1C[C@H]1c1ccc(F)cc1F",
        "output": "297"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=CCCCCCO.CN(C)C=O.O=C1CCC(=O)N1Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)=CCCCCCBr",
        "output": "581"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)O.CC(C)SCC1C2CN(C(=O)OC(C)(C)C)CC2CC1N1CCC(NC(=O)OCc2ccccc2)C1=O.CCOC(C)=O.O.O=S([O-])OO.[K+]>>CC(C)S(=O)(=O)CC1C2CN(C(=O)OC(C)(C)C)CC2CC1N1CCC(NC(=O)OCc2ccccc2)C1=O",
        "output": "847"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)C1CC(=O)N(c2ccc(OCc3ccccc3)cc2)C1.[BH4-].[Na+]>>O=C1CC(CO)CN1c1ccc(OCc2ccccc2)cc1",
        "output": "343"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(COc2ccc(Br)cn2)CC1.CS(=O)(=O)c1ccc(B(O)O)cc1.O.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)(C)OC(=O)N1CCC(COc2ccc(-c3ccc(S(C)(=O)=O)cc3)cn2)CC1",
        "output": "833"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)N.O=[N+]([O-])c1cc(F)cc(S(=O)(=O)Cl)c1>>CC(C)(C)NS(=O)(=O)c1cc(F)cc([N+](=O)[O-])c1",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(O)c1ccc2c(c1)NC(=O)CC2.ClC(Cl)Cl.O=[Mn]=O>>CC(=O)c1ccc2c(c1)NC(=O)CC2",
        "output": "32"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cc1c(C(=O)N(C)Cc2ccc(Cl)cc2Cl)[nH]c(C(=O)O)c1S(=O)(=O)c1ccccc1.Cl.NCc1n[nH]c2ccccc12.On1nnc2ccccc21>>Cc1c(C(=O)N(C)Cc2ccc(Cl)cc2Cl)[nH]c(C(=O)NCc2n[nH]c3ccccc23)c1S(=O)(=O)c1ccccc1",
        "output": "137"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)Nc1nc(Cl)cc(-c2ccccc2)n1.CCCCO.COC(=O)C1(c2ccc(N)cc2)CCC1.ClCCl>>COC(=O)C1(c2ccc(Nc3cc(-c4ccccc4)nc(NC(C)(C)C)n3)cc2)CCC1",
        "output": "161"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCC(NC1CCc2cc(F)cc(F)c2C1)C(=O)O.CN(CC(C)(C)C)CC(C)(C)n1cnc(N)c1>>CCCC(NC1CCc2cc(F)cc(F)c2C1)C(=O)Nc1cn(C(C)(C)CN(C)CC(C)(C)C)cn1",
        "output": "692"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cc1ccc(C(=O)Nc2ccc([N+](=O)[O-])cc2)c(-c2ccc(C(F)(F)F)cc2)c1.[H][H].[Pd]>>Cc1ccc(C(=O)Nc2ccc(N)cc2)c(-c2ccc(C(F)(F)F)cc2)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)C1CN(C(=O)OC(C)(C)C)c2cc(Cl)ccc2O1.ClCCl.O=C(O)C(F)(F)F>>C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)C1CNc2cc(Cl)ccc2O1",
        "output": "830"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cl.FC1(F)CCC(c2noc(C3CC3)c2COC2CCC3(CC2)OCCO3)CC1>>O=C1CCC(OCc2c(C3CCC(F)(F)CC3)noc2C2CC2)CC1",
        "output": "251"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(c1ccc2ccccc2c1-c1cccc2ccccc12)C(C)(C)C.COc1ccc2c(Cl)ccnc2c1.Cc1ccccc1.Cc1csc(-c2cn(CCO)c(=O)cn2)c1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2]>>COc1ccc2c(OCCn3cc(-c4cc(C)cs4)ncc3=O)ccnc2c1",
        "output": "651"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CC(=O)N(C)C.CCOC(C)=O.N#Cc1ccc(F)c(C(F)(F)F)c1>>N#Cc1ccc(N2CCOCC2)c(C(F)(F)F)c1",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOCC.CI.CS(C)=O.O=C(c1cccc2ccccc12)N1CC(CO)C(CN2CCC(c3ccc(F)cc3)CC2)C1.[K+].[OH-]>>COCC1CN(C(=O)c2cccc3ccccc23)CC1CN1CCC(c2ccc(F)cc2)CC1",
        "output": "140"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CO.COC(=O)c1nc(-c2c(F)ccc(OC)c2F)sc1NC(=O)OC(C)(C)C.Cl.O.O.O.[Cl-].[Li+].[Na+].[OH-]>>COc1ccc(F)c(-c2nc(C(=O)O)c(NC(=O)OC(C)(C)C)s2)c1F",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)O.CCCCCCCC(=O)N(C)Cc1cccc(-c2ccc(C=CC(=O)OC)c(F)c2)c1.CO.O.[Na+].[OH-]>>CCCCCCCC(=O)N(C)Cc1cccc(-c2ccc(C=CC(=O)O)c(F)c2)c1",
        "output": "58"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1cc(Br)cc(Nc2ncc(F)c(C(F)F)n2)c1.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cc(Nc2ncc(F)c(C(F)F)n2)cc(B2OC(C)(C)C(C)(C)O2)c1",
        "output": "942"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1ncc[nH]1.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[K+].[K+]>>O=[N+]([O-])c1ccc(-n2ccnc2Br)cc1",
        "output": "701"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C(N)=NO.O=C(O)C1CC(c2cccc(C(F)(F)F)c2)CN(C(=O)N2CCC(O)CC2)C1>>CC(C)c1noc(C2CC(c3cccc(C(F)(F)F)c3)CN(C(=O)N3CCC(O)CC3)C2)n1",
        "output": "728"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)C(C)CCCOc1cccc(O)c1C=O.CCOC(=O)C(C)CCCOc1cccc(OC)c1C=O.CCOCC.Cl.[I-].[I-].[Mg+2]>>CC(CCCOc1cccc(O)c1C=O)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(CCN1CCCC1)C(=O)c1cnc(Cl)c(Cl)c1.Cn1ccc(Nc2ncnc3ccc(O)cc23)n1>>CN(CCN1CCCC1)C(=O)c1cnc(Oc2ccc3ncnc(Nc4ccn(C)n4)c3c2)c(Cl)c1",
        "output": "516"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.C[O-].ClCCl.N#Cc1ccc(Br)cc1F.[Na+]>>COc1cc(Br)ccc1C#N",
        "output": "485"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.CCOC(=O)c1ccc2ccccn2c1=O.CCOC(C)=O.O=[N+]([O-])O>>CCOC(=O)c1cc([N+](=O)[O-])c2ccccn2c1=O",
        "output": "328"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cl.ClC(Cl)Cl.ClCCCl.NCCc1c[nH]c2ccccc12.O=C(O)c1cc(OCc2ccccc2)c(OCc2ccccc2)c(OCc2ccccc2)c1>>O=C(NCCc1c[nH]c2ccccc12)c1cc(OCc2ccccc2)c(OCc2ccccc2)c(OCc2ccccc2)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)CC1NC(C(=O)Nc2ccc(C#N)cc2)C(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12.CS(C)=O.OO.[Na+].[OH-]>>CC(C)(C)CC1NC(C(=O)Nc2ccc(C(N)=O)cc2)C(c2cccc(Cl)c2)C12C(=O)Nc1cc(Cl)ccc12",
        "output": "180"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2C(C)(C)COC.CN(C)C=O.O.O=C([O-])[O-].OCCCCCCBr.[K+].[K+]>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCCCCCO)cc1CC2C(C)(C)COC",
        "output": "75"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(C(C)=O)cc(C(=O)NC(C)c2ccc(F)cc2)c1.O.[Li+].[OH-]>>CC(=O)c1cc(C(=O)O)cc(C(=O)NC(C)c2ccc(F)cc2)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CC#N.CCN(C(C)C)C(C)C.O=[N+]([O-])c1ccc(F)c(F)c1>>O=[N+]([O-])c1ccc(N2CCCCC2)c(F)c1",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Nc1nc2ccccc2s1.O=C(Cl)c1ccccc1.c1ccncc1>>O=C(Nc1nc2ccccc2s1)c1ccccc1",
        "output": "673"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)C1CC(=O)C1.CC(Cl)Cl.CCOC(C)=O.Clc1cccc(Cl)c1COc1ccc2c(c1)OCC21CCNCC1.[Na+]>>CC(C)(C)OC(=O)C1CC(N2CCC3(CC2)COc2cc(OCc4c(Cl)cccc4Cl)ccc23)C1",
        "output": "187"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(-c2nc3ccccc3n2Cc2ccc(-c3ccccc3C(=O)OC(C)(C)C)cc2)cc1.O=C(O)C(F)(F)F>>COc1ccc(-c2nc3ccccc3n2Cc2ccc(-c3ccccc3C(=O)O)cc2)cc1",
        "output": "752"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(=O)CC1.NC1CCCc2cccnc21.[Na+]>>CC(C)(C)OC(=O)N1CCC(NC2CCCc3cccnc32)CC1",
        "output": "236"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN1CCC[C@H]1C(=O)O.CO.O=S(Cl)Cl>>COC(=O)[C@@H]1CCCN1C",
        "output": "536"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Nc1c(F)c(F)c(C(=O)O)c(F)c1F.O=S(Cl)Cl>>COC(=O)c1c(F)c(F)c(N)c(F)c1F",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)C1CC(C(=O)OC(C)(C)C)N(C(=O)CNC(=O)Nc2cccc(C)c2)C1c1ccccc1.O.[K+].[OH-]>>Cc1cccc(NC(=O)NCC(=O)N2C(C(=O)OC(C)(C)C)CC(C(=O)O)C2c2ccccc2)c1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)CCNC(=O)C(C)(C)NC(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CC(C)CCNC(=O)C(C)(C)N",
        "output": "431"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COC(=O)[C@H](Cc1ccc(CCCc2ccc3c(n2)NCCC3)cc1)NC(=O)c1ccccc1Cl.[Li+].[OH-]>>O=C(N[C@@H](Cc1ccc(CCCc2ccc3c(n2)NCCC3)cc1)C(=O)O)c1ccccc1Cl",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNCC1.CS(C)=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Br)cc1.[K+].[K+]>>O=[N+]([O-])c1ccc(N2CCCCC2)cc1",
        "output": "294"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C[C@@H]1CN(c2csc3cc(F)ccc23)CCN1CCN1CCCc2cc(C#N)ccc21.O>>C[C@@H]1CN(c2csc3cc(F)ccc23)CCN1CCN1CCCc2cc(C(N)=O)ccc21",
        "output": "419"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)CC(C)(C)N.CC(Cl)Cl.CCN(CC)CC.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>CC(C)(C)CC(C)(C)NC(=O)c1ccc([N+](=O)[O-])cc1",
        "output": "271"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CCCC(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.N.NCCN1CCOCC1.O.On1nnc2ccccc21>>C#CCCC(=O)NCCN1CCOCC1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1=C(Nc2ccccc2O)OCC1=O.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].OCCCl.[K+].[K+]>>CCOC(=O)C1=C(Nc2ccccc2OCCO)OCC1=O",
        "output": "74"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.C1CCOC1.CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1COC(C)(C)N1C(=O)OC(C)(C)C.[I-].[Na+]>>CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](OCc1ccccc1)[C@H]1COC(C)(C)N1C(=O)OC(C)(C)C",
        "output": "464"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(-c2ccc(F)cc2)ccc1OCCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1.[Na+].[OH-]>>CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCOc2ccc(-c3ccc(F)cc3)cc2C(=O)O)cs1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)CC(N)CC(C)(C)N1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(CNc2ccccc2)cc1>>CC1(C)CC(NC(=O)c2ccc(CNc3ccccc3)cc2)CC(C)(C)N1",
        "output": "821"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCCn1c(N2CCCN(CCC3(c4ccccc4)CCNC3)CC2)nc2ccccc21.COc1cc(C(=O)O)cc2c1OCCO2.Cl>>CCOCCn1c(N2CCCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c5c(c4)OCCO5)C3)CC2)nc2ccccc21",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.CN.Cl.O.O=C(O)Cc1ccc(Br)cn1.On1nnc2ccccc21>>CNC(=O)Cc1ccc(Br)cn1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)/N=N/C(=O)OCC.COc1cc(NCc2cc3cc(Cl)cc(O)c3[nH]c2=O)ccc1C#N.OCCN1CCOCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc(NCc2cc3cc(Cl)cc(OCCN4CCOCC4)c3[nH]c2=O)ccc1C#N",
        "output": "547"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCN1CC(=O)N(CO)C1=O.CC1(C)[C@H](C(=O)O)[C@@H]1/C=C\\C(=O)OCC(F)(F)F.c1ccccc1>>C#CCN1CC(=O)N(COC(=O)[C@@H]2[C@H](/C=C\\C(=O)OCC(F)(F)F)C2(C)C)C1=O",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCCCO.CN1CC(CCCl)OC1=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(N2CCNCC2)cc1.[I-].[K+].[Na+].[Na+]>>CN1CC(CCN2CCN(c3ccc([N+](=O)[O-])cc3)CC2)OC1=O",
        "output": "138"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(C)=O.Fc1cccnc1-c1ccc(Cl)cc1.OCC1CC1>>Clc1ccc(-c2ncccc2OCC2CC2)cc1",
        "output": "823"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)c1cccc(-c2c(C#N)c(Cl)nc3ccc(Cl)cc23)c1.CCNC>>CCN(C)c1nc2ccc(Cl)cc2c(-c2cccc(C(C)C)c2)c1C#N",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(N=[N+]=[N-])CC1.CO.[Pd]>>CC(C)(C)OC(=O)N1CCC(N)CC1",
        "output": "89"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1ccccn1.Cl.Fc1ccc(OC[C@@H]2CC[C@H]3CNCCN3C2)cc1>>Fc1ccc(OC[C@@H]2CC[C@H]3CN(c4ccccn4)CCN3C2)cc1",
        "output": "647"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)NC(=O)[C@@H]1CC[C@H](Nc2cc(CN3CCCCC3)ccc2[N+](=O)[O-])CC1.CCO.O=C[O-].[NH4+].[Pd]>>CC(C)NC(=O)[C@H]1CC[C@@H](Nc2cc(CN3CCCCC3)ccc2N)CC1",
        "output": "507"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1CCNCC1.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cn(S(=O)(=O)c2ccccc2)c2ccccc12>>CN1CCN(C(=O)c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)CC1",
        "output": "256"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCC(C(=O)c1ccc(Cl)cc1)c1ccc(Br)cc1.CO.[BH4-].[Na+]>>CCCC(c1ccc(Br)cc1)C(O)c1ccc(Cl)cc1",
        "output": "24"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccccc1C(=O)Cl.Nc1ccccc1.[Ca+2].[Cl-].[Cl-].c1ccncc1>>Cc1ccccc1C(=O)Nc1ccccc1",
        "output": "11"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)O/C(=C2/C(=O)Nc3cc(F)ccc32)C=C1NC(=O)c1ccc(F)nc1.CCOC(C)=O.CN(C)C=O.OCCN1CCNCC1>>CC1(C)O/C(=C2/C(=O)Nc3cc(F)ccc32)C=C1NC(=O)c1ccc(N2CCN(CCO)CC2)nc1",
        "output": "756"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)N1CCNCC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[P-](F)(F)(F)(F)F.N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)O)cc4)nn23)cc1.O>>CC(C)N1CCN(C(=O)c2ccc(-c3ccc4ncc(-c5ccc(C#N)cc5)n4n3)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(CNc2nc(CCC(=O)O)nc3sc4c(c23)CCCC4)cc1Cl.ClCCl.O=S(Cl)Cl>>COc1ccc(CNc2nc(CCC(=O)Cl)nc3sc4c(c23)CCCC4)cc1Cl",
        "output": "53"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(OC)OC.O=C(O)CCC(=O)Nc1ccc(C(F)(F)F)cn1.O=S(Cl)Cl>>COC(=O)CCC(=O)Nc1ccc(C(F)(F)F)cn1",
        "output": "195"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COc1ccc2c(c1)c1c(n2C)-c2ccccc2SC1.O.O=S([O-])OO.[K+]>>COc1ccc2c(c1)c1c(n2C)-c2ccccc2S(=O)(=O)C1",
        "output": "730"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.Cl.Clc1ccc(C(c2ccc(Cl)cc2)c2ccc3ncnc(Cl)c3c2)cc1.NC1CCN(c2ccccn2)CC1>>Clc1ccc(C(c2ccc(Cl)cc2)c2ccc3ncnc(NC4CCN(c5ccccn5)CC4)c3c2)cc1",
        "output": "110"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#C[Si](C)(C)C.CCOC(C)=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Fc1cc(I)ccc1Nc1c(-c2nnc(NCCN3CCOCC3)o2)ccc(F)c1F.I[Cu]I.NCCC1COC(CCN)C1CCN>>C[Si](C)(C)C#Cc1ccc(Nc2c(-c3nnc(NCCN4CCOCC4)o3)ccc(F)c2F)c(F)c1",
        "output": "826"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)O.CC1(C)Cc2ccc(F)c(C#N)c2O1.[Cl-].[K+].[Na+].[OH-]>>CC1(C)Cc2ccc(F)c(C(N)=O)c2O1",
        "output": "419"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C1c2ccccc2C(=O)c2cc([N+](=O)[O-])ccc21.[H][H].[Na+].[Ni].[OH-]>>Nc1ccc2c(c1)C(=O)c1ccccc1C2=O",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN=C=NCCCN(C)C.CCOc1cccc(-n2cc(C(Nc3ccc(C(=O)O)cc3)C3CCCCC3)c(CC)n2)c1.CN(C)C=O.COC(=O)C(C)CN.Cl.O.O.On1nnc2ccccc21>>CCOc1cccc(-n2cc(C(Nc3ccc(C(=O)NCC(C)C(=O)OC)cc3)C3CCCCC3)c(CC)n2)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CC=C(c2cccc(O)c2)CC1.CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CCOC(C)=O.CN(C)c1ccccn1.ClCCl>>CC(C)(C)OC(=O)N1CC=C(c2cccc(O[Si](C)(C)C(C)(C)C)c2)CC1",
        "output": "746"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(=O)C1CCC(=O)CC1.Clc1ccc(OC2CCNCC2)cc1Cl.O=C([O-])O.[Na+].[Na+]>>CCOC(=O)C1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)C(=O)Cl.CCN1CCCCC1.COC(=O)[C@@H](N)Cc1ccccc1.Cl.ClCCl.NC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)O.c1ccncc1>>COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1",
        "output": "129"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.C[O-].Clc1ccc(N2CCC3(CC2)CCN(C2CCC2)CC3)nn1.[Na+]>>COc1ccc(N2CCC3(CC2)CCN(C2CCC2)CC3)nn1",
        "output": "407"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.N#Cc1ccc(F)c(F)c1.O=C(O)c1c[nH]cn1>>N#Cc1ccc(-n2cnc(C(=O)O)c2)c(F)c1",
        "output": "701"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCCOCCO.CC(C)OC(=O)/N=N/C(=O)OC(C)C.O=[N+]([O-])c1cccc(O)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)NCCOCCOc1cccc([N+](=O)[O-])c1",
        "output": "478"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COCCBr.Cc1cc(C2CC2)cnc1N1CCN(C(=O)c2ccc(N3C(=O)OC[C@H]3CO)cc2)CC1>>COCCOC[C@@H]1COC(=O)N1c1ccc(C(=O)N2CCN(c3ncc(C4CC4)cc3C)CC2)cc1",
        "output": "95"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCC(=O)Cl.ClCCl.Nc1cc2c3c(c1)c1c(n3CC2)CCCCCC1>>CCCCCCC(=O)Nc1cc2c3c(c1)c1c(n3CC2)CCCCCC1",
        "output": "9"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C(C#N)=NOC(N1CCOCC1)=[N+](C)C.COc1ccc(C2=NN(C3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)C(=O)C(C)(C)C2)cc1OC.Cc1[nH]c2c(-c3c(OCC4CC4)ccc4c3OCO4)ncnc2c1C(=O)O.ClCCl.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+]>>COc1ccc(C2=NN(C3CCN(C(=O)[C@@H](Cc4ccccc4)NC(=O)c4c(C)[nH]c5c(-c6c(OCC7CC7)ccc7c6OCO7)ncnc45)CC3)C(=O)C(C)(C)C2)cc1OC",
        "output": "989"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COc1cc(OC)c(F)c(N2Cc3cnc4c(cc(CN5CCN(C)CC5)n4S(=O)(=O)c4ccccc4)c3C(C)(C)C2=O)c1F.[F-]>>COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCN(C)CC5)cc4c3C(C)(C)C2=O)c1F",
        "output": "831"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O.O=C(O)c1cc2cc(Br)ccc2cc1O.O=C([O-])O.O=S(=O)(O)O.[Na+]>>CCOC(=O)c1cc2cc(Br)ccc2cc1O",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1C[C@@H]2CNCCN2C1.CC(C)Oc1cc(F)ccc1[N+](=O)[O-].CS(C)=O.O.O=C([O-])[O-].[K+].[K+]>>CC(C)Oc1cc(N2CCN3CCC[C@@H]3C2)ccc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNC1.CCO.O=[N+]([O-])c1oc2ccc(CBr)cc2c1-c1ccccc1>>O=[N+]([O-])c1oc2ccc(CN3CCCC3)cc2c1-c1ccccc1",
        "output": "248"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCC(C(=O)OC)c1c(C)nc(Cl)nc1-c1ccc(C)cc1.CCN(CC)CC.O=C(NC1CCNCC1)c1ccccc1.O=C([O-])O.[Na+]>>CCCC(C(=O)OC)c1c(C)nc(N2CCC(NC(=O)c3ccccc3)CC2)nc1-c1ccc(C)cc1",
        "output": "36"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(N2Cc3ccccc3CC2=O)CC1.O=C1Nc2ccccc2CC1C1CCNCC1>>O=C1Cc2ccccc2CN1C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[B-](F)(F)F.O=C(O)c1cc2cc(C(=O)N3CCN(C4CCCC4)CC3)ccc2[nH]1>>O=C(c1ccc2[nH]c(C(=O)N3CCCC3)cc2c1)N1CCN(C2CCCC2)CC1",
        "output": "605"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.Nc1cc(C#Cc2cncc(Cl)c2)ccc1F.c1ccncc1>>CC(=O)Nc1cc(C#Cc2cncc(Cl)c2)ccc1F",
        "output": "6"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.Cc1cccc(C(=O)Cl)c1.Cl.NCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O>>Cc1cccc(C(=O)NCc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)c1",
        "output": "411"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)O.CC1(CO[Si](C)(C)C(C)(C)C)Cc2nnc(-c3ccccc3C(F)(F)F)n2CCS1.Cc1ccccc1.Cl.O=C([O-])O.[Na+]>>CC1(CO)Cc2nnc(-c3ccccc3C(F)(F)F)n2CCS1",
        "output": "708"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO[C@@H](Cc1ccc(O)cc1C)C(=O)OC.Cc1cc(-c2nc(CCl)c(C)o2)ccc1F.O=C([O-])[O-].[Cs+].[Cs+].[I-].[K+]>>CCO[C@@H](Cc1ccc(OCc2nc(-c3ccc(F)c(C)c3)oc2C)cc1C)C(=O)OC",
        "output": "760"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC[N+](CC)(CC)Cc1ccccc1.COC(=O)c1c(C)[nH]c2ncc(F)cc12.ClCCl.O=S(=O)(Cl)c1ccccc1.[Cl-].[Na+].[OH-]>>COC(=O)c1c(C)n(S(=O)(=O)c2ccccc2)c2ncc(F)cc12",
        "output": "354"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1Cc2ccccc2C[C@H]1C(=O)O.CCN(C(C)C)C(C)C.CN(C)C=O.Cl.ClCCCl.N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(c2ccccc2NC(=O)OCC2c3ccccc3-c3ccccc32)CC1.On1nnc2cccnc21>>CC(C)(C)OC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(c2ccccc2NC(=O)OCC2c3ccccc3-c3ccccc32)CC1",
        "output": "131"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "B.C1CCOC1.C1CCOC1.COc1cc(Br)ccc1C1(C(=O)O)CCC1>>COc1cc(Br)ccc1C1(CO)CCC1",
        "output": "231"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(CCCc2ccc(C(=O)O)cc2)c(OCc2ccccc2)c1.CS(C)=O.[C-]#N.[Na+]>>O=C(O)c1ccc(CCCc2ccc(O)cc2OCc2ccccc2)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1cccc(Br)c1.O=[N+]([O-])c1cc(O)ccc1Cl>>O=[N+]([O-])c1cc(OCc2cccc(Br)c2)ccc1Cl",
        "output": "127"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.COc1cc(C=O)cc([N+](=O)[O-])c1O.[Al+3].[Cl-].[Cl-].[Cl-].c1ccncc1>>O=Cc1cc(O)c(O)c([N+](=O)[O-])c1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(Cl)c(N)c1.Cl.FC(F)(F)c1cc(Cl)nc(-c2cnccn2)n1>>COc1ccc(Cl)c(Nc2cc(C(F)(F)F)nc(-c3cnccn3)n2)c1",
        "output": "161"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc(F)c(NC(=O)c2ccc(F)c(Oc3ccnc(-c4cc(C(=O)NCCCNC(=O)OC(C)(C)C)c[nH]4)c3)c2)c1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(F)c(NC(=O)c2ccc(F)c(Oc3ccnc(-c4cc(C(=O)NCCCN)c[nH]4)c3)c2)c1",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cc1nc(-c2ccccc2)c[nH]1.Cl.Clc1ccc(CBr)cc1.[H-].[Na+]>>Cc1nc(-c2ccccc2)cn1Cc1ccc(Cl)cc1",
        "output": "658"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)C1Nc2cc(Cl)cc(Cl)c2C2C=CCC12.[Na+].[OH-]>>O=C(O)C1Nc2cc(Cl)cc(Cl)c2C2C=CCC12",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CNC(=O)c1cc(C(=O)O)c(C)cc1C1CCC1.Cc1nnc(-c2cc(C(=O)O)c(C)cc2C2CCC2)[nH]1.Cl.c1cc2[nH]ncc2cc1C1CCNCC1.c1cn2cc(C3CCNCC3)ccc2n1>>Cc1nnc(-c2cc(C(=O)N3CCC(c4ccc5nccn5c4)CC3)c(C)cc2C2CCC2)[nH]1",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)[O-].COC(=O)c1ccc2c(C3CCCCC3)c(-c3cc(F)ccc3N)[nH]c2c1.O=C(Cl)CCl.O=C([O-])O.[Na+].[Na+]>>COC(=O)c1ccc2c(C3CCCCC3)c(-c3cc(F)ccc3NC(=O)CCl)[nH]c2c1",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CN(C)C(=O)[C@@H](CCO)N1CCNCCC1=O.Cl.O=C(O)/C=C/c1cccc(Cl)c1>>CN(C)C(=O)[C@@H](CCO)N1CCN(C(=O)/C=C/c2cccc(Cl)c2)CCC1=O",
        "output": "811"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(Cc1ccc(NCCCN2CCOc3cc(F)ccc32)cc1)C(=O)OC.O.[Li+].[OH-]>>CCOC(Cc1ccc(NCCCN2CCOc3cc(F)ccc32)cc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(N)cc1.Cl.Cl[Sn]Cl.O.O.O.O=N[O-].[Na+]>>Cc1ccc(NN)cc1",
        "output": "109"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClC(Cl)Cl.N.O=C(O)c1cc2ccccc2[nH]1.O=S(Cl)Cl>>NC(=O)c1cc2ccccc2[nH]1",
        "output": "136"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[O-].CCOC(C)=O.COc1cc2ncnc(Cl)c2cc1OC.CS(C)=O.Nc1ccc(O)cc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+].[K+]>>COc1cc2ncnc(Oc3ccc(N)c([N+](=O)[O-])c3)c2cc1OC",
        "output": "890"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)C1CCC(C(=O)Cl)CC1.CCC(N)c1nnc(C2CCCC2)[nH]c1=O>>CCC(NC(=O)C1CCC(C(C)(C)C)CC1)c1nnc(C2CCCC2)[nH]c1=O",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.NS(=O)(=O)c1cc(C(=O)O)cc([N+](=O)[O-])c1-c1ccccc1.[Pd]>>Nc1cc(C(=O)O)cc(S(N)(=O)=O)c1-c1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)C(CC(=O)OC(C)(C)C)Cc1ccc(-c2ccccc2)cc1.O=C(O)C(F)(F)F>>COC(=O)C(CC(=O)O)Cc1ccc(-c2ccccc2)cc1",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.Cc1c(C)c2c3c(cc(C)c2[nH]c1=O)CC(CN=[N+]=[N-])O3.[H][H].[Pd]>>Cc1c(C)c2c3c(cc(C)c2[nH]c1=O)CC(CN)O3",
        "output": "89"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CI.O=C([O-])[O-].Oc1cc(Br)c2c(c1)CCCC2.[K+].[K+]>>COc1cc(Br)c2c(c1)CCCC2",
        "output": "62"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCC.CNCC1(c2ccc(F)cc2)CCN(C)CC1.Cc1c(C#N)cc(C(=O)Cl)c2ccccc12>>Cc1c(C#N)cc(C(=O)N(C)CC2(c3ccc(F)cc3)CCN(C)CC2)c2ccccc12",
        "output": "201"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.C[C@@H](CO)CCN.Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)O)ccc21.F[P-](F)(F)(F)(F)F>>C[C@@H](CO)CCNC(=O)c1ccc2c(c1)nc(Nc1nc3ccc(OC(F)(F)F)cc3s1)n2C",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(C)=O.COc1cc([N+](=O)[O-])c(OC)cc1N1CCC(N2CCN(CCF)CC2)CC1.[Pt]>>COc1cc(N2CCC(N3CCN(CCF)CC3)CC2)c(OC)cc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN.Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)C(CN2C(=O)c3ccccc3C2=O)C1>>Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)C(CN)C1",
        "output": "242"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.Nc1c(Cl)cc(C(F)(C(F)(F)F)C(F)(F)F)cc1Br.O=S(=O)(O)O>>CC(=O)Nc1c(Cl)cc(C(F)(C(F)(F)F)C(F)(F)F)cc1Br",
        "output": "6"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)OC(=O)Cc1cc(OCc2ccccc2)ccc1[N+](=O)[O-].CCO.CCOCC.O.[Cl-].[Fe].[NH4+]>>CC(C)OC(=O)Cc1cc(OCc2ccccc2)ccc1N",
        "output": "202"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OC[C@@H]1CCCN1>>COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OC[C@@H]1CCCN1C(C)=O",
        "output": "125"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)OCc1ccccc1.CO.[H][H].[Pd]>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)O",
        "output": "186"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.ClCCl.F[B-](F)(F)F.NN.O=C(O)COc1ccc(Cl)cc1[C@@H]1c2ccccc2CCN1C(=O)OCc1ccccc1>>NNC(=O)COc1ccc(Cl)cc1[C@@H]1c2ccccc2CCN1C(=O)OCc1ccccc1",
        "output": "459"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(C)(C)N(Cc1ccccc1)CC(O)c1ccc(OCc2ccccc2)c([N+](=O)[O-])c1.[Fe]>>CC(C)(C)N(Cc1ccccc1)CC(O)c1ccc(OCc2ccccc2)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.Cl.ClCCl.N[C@H](CO)Cc1ccc(O)cc1.O=Cc1ccccc1.[Na+]>>OC[C@H](Cc1ccc(O)cc1)NCc1ccccc1",
        "output": "468"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)[C@@H](Cc1cc(C)c(OCc2ccccc2)c(C)c1)OC(=O)N1CCC(c2cc3ccccc3[nH]c2=O)CC1.O.[Li+].[OH-]>>Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)O)cc(C)c1OCc1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Oc1cc(Br)ccc1Cl.[C-]#N.[C-]#N.[Zn+2]>>N#Cc1ccc(Cl)c(O)c1",
        "output": "65"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(CO)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1.ClCCl>>CC(C)(C=O)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCN(C(C)C)C(C)C.Cc1nn2c(-c3cccc(Cl)c3)cc(Cl)nc2c1I.OC[C@@H]1CCCN1>>Cc1nn2c(-c3cccc(Cl)c3)cc(N3CCC[C@H]3CO)nc2c1I",
        "output": "162"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1nc2cc(Br)cc(C)c2nc1OC.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COc1nc2cc(Br)cc(CBr)c2nc1OC",
        "output": "625"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc2ccc(Br)cc2c1.C1COCCO1.CC(C)(C)OC(=O)N1CCNC(=O)C1.CNC1CCCCC1NC.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(c2ccc3ccc(Br)cc3c2)C(=O)C1",
        "output": "809"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCCCCN2C(=O)c3ccccc3C2=O)C1c1cccc([N+](=O)[O-])c1.NN.O>>COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCCCCN)C1c1cccc([N+](=O)[O-])c1",
        "output": "242"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CC1CCCCC1)C(=O)O.CC(C)(C)c1cccc(C[C@H](N)C(N)=O)c1.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.Cl.On1nnc2ccccc21>>CC(C)(C)OC(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](Cc1cccc(C(C)(C)C)c1)C(N)=O",
        "output": "133"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCc3ccnc(N)c3)c3ccccc23)cc1.ClCCl.O=C(Cl)CCl>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCc3ccnc(NC(=O)CCl)c3)c3ccccc23)cc1",
        "output": "332"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cccc(CCc2ccccc2OC2CCCN(C(=O)OC(C)(C)C)C2)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1cccc(CCc2ccccc2OC2CCCN(C)C2)c1",
        "output": "881"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.Cc1nc2ccc(CO)cc2o1.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>Cc1nc2ccc(C=O)cc2o1",
        "output": "179"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)N1CCC(CC#N)(NC(=O)OC(C)(C)C)CC1.CO.[Ni]>>CCOC(=O)N1CCC(CCN)(NC(=O)OC(C)(C)C)CC1",
        "output": "246"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@H](C(=O)O)CC1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.ClCCl.F[P-](F)(F)(F)(F)F.NCc1cccc([N+](=O)[O-])c1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@H](C(=O)NCc2cccc([N+](=O)[O-])c2)CC1",
        "output": "599"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.Nc1cc(Br)cc([N+](=O)[O-])c1.O.c1ccncc1>>CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1",
        "output": "6"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.OCc1cc(F)c2nc(Br)sc2c1.[Mn+4].[O-2].[O-2]>>O=Cc1cc(F)c2nc(Br)sc2c1",
        "output": "179"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "B.C1CCOC1.C1CCOC1.CCCC(CCC)N1C(=O)C(C)Oc2c(-c3ccc(C)cc3C)cccc21.Cl.[NH4+].[OH-]>>CCCC(CCC)N1CC(C)Oc2c(-c3ccc(C)cc3C)cccc21",
        "output": "363"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CCNCCOc1cc(C)c(-c2cccc(COc3ccc(CCC(=O)OCC)c(F)c3)c2)c(C)c1.CN(C)c1ccncc1.c1ccncc1>>CCOC(=O)CCc1ccc(OCc2cccc(-c3c(C)cc(OCCN(CC)C(C)=O)cc3C)c2)cc1F",
        "output": "369"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc(Cc2c(-c3ccc(F)cc3)nn3cc(OC)ccc23)n1.Cl.[Na+].[OH-]>>COc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccc(F)cc3)nn2c1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)CCNc1cccc(-c2ccccc2)c1.O.[Li+].[OH-]>>O=C(O)CCNc1cccc(-c2ccccc2)c1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.CC(=O)O.O=C(O)c1cccc(O)c1>>O=C(O)c1ccc(Br)c(O)c1",
        "output": "98"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.N#Cc1cc(O)cc(C(=O)O)c1.O=S(=O)(O)O>>COC(=O)c1cc(O)cc(C#N)c1",
        "output": "33"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCCN1CCCC1.CC(Cc1ccccn1)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3n[nH]c4cc(F)ccc34)nc12.CN(C)C=O.Cl.[H-].[Na+]>>CC(Cc1ccccn1)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(CCN4CCCC4)c4cc(F)ccc34)nc12",
        "output": "577"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.Cn1ncc2c1CNC2.N#Cc1c(Cl)ncnc1Cl.O>>Cn1ncc2c1CN(c1ncnc(Cl)c1C#N)C2",
        "output": "296"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Brc1cccc(OCC2CCCCCC2)c1.C=CCNC(=O)C(F)(F)F>>O=C(NC/C=C/c1cccc(OCC2CCCCCC2)c1)C(F)(F)F",
        "output": "539"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CN(C)C=O.C[C@@H](CO)NC(=O)OCc1ccccc1.c1c[nH]cn1>>C[C@@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)NC(=O)OCc1ccccc1",
        "output": "602"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCc1nnc(-c2ccc([N+](=O)[O-])cc2)n1-c1ccc(OC)cc1.Cl.O=[Pt]>>CCc1nnc(-c2ccc(N)cc2)n1-c1ccc(OC)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CNC.COC(=O)c1ccc(F)c(F)c1.CS(C)=O.Cl.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(N(C)C)c(F)c1",
        "output": "773"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "N[C@H]1CCCc2ccccc21.O=Cc1cc(F)cc(C(F)(F)F)c1>>Fc1cc(CN[C@H]2CCCc3ccccc32)cc(C(F)(F)F)c1",
        "output": "683"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)C(C)(C)N1Cc2ccc(-c3ccc([N+](=O)[O-])cc3)cc2C1=O.COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O>>COC(=O)C(C)(C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.Br.Br.CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCNC4)n[nH]c2c1.N#Cc1ncccc1C=O>>CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3cccnc3C#N)C4)n[nH]c2c1",
        "output": "757"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCN1.CC(c1ccc(Cl)cc1Cl)C(O)(c1ccnc(OCC(=O)O)c1)C(F)(F)F.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[P-](F)(F)(F)(F)F.O>>CC(c1ccc(Cl)cc1Cl)C(O)(c1ccnc(OCC(=O)N2CCOCC2)c1)C(F)(F)F",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(N)c1ccccc1.CCOC(C)=O.O=C1C2CC3CC1CC(O)(C3)C2.O=CO.[Ir]>>CC(NC1C2CC3CC1CC(O)(C3)C2)c1ccccc1",
        "output": "589"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.Cc1cc(C(=O)O)ccc1N.Cl.O.O=C(Cl)OCc1ccccc1.O=C([O-])O.[Na+]>>Cc1cc(C(=O)O)ccc1NC(=O)OCc1ccccc1",
        "output": "509"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Cc1c(Cl)cccc1CN.ClC(Cl)Cl.O>>Cc1c(Cl)cccc1CNC(=O)OC(C)(C)C",
        "output": "686"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(=O)(=O)Cl.Nc1ccc(-c2ncnc3cc(C4=CCN(C(=O)N5CCOCC5)CC4)sc23)cc1.c1ccncc1>>CS(=O)(=O)Nc1ccc(-c2ncnc3cc(C4=CCN(C(=O)N5CCOCC5)CC4)sc23)cc1",
        "output": "194"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)c1cn(C2CCCC2)c2c(OC)c(F)c(F)c([N+](=O)[O-])c2c1=O.CN(C)C=O.[Pd]>>CCOC(=O)c1cn(C2CCCC2)c2c(OC)c(F)c(F)c(N)c2c1=O",
        "output": "202"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CN(c1cc2cc(n1)CC=CCc1cccc(c1)CC(C)(NC(=O)OC(C)(C)C)C(=O)OC2)S(C)(=O)=O.[Pd]>>CN(c1cc2cc(n1)CCCCc1cccc(c1)CC(C)(NC(=O)OC(C)(C)C)C(=O)OC2)S(C)(=O)=O",
        "output": "143"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cc1ccccc1.O=C1CCC(C(=O)O)N1.O=S(=O)(O)O.[Na+].[OH-]>>COC(=O)C1CCC(=O)N1",
        "output": "195"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)[O-].CC(Oc1ccc(Br)cc1)C1CC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.[K+]>>CC(Oc1ccc(B2OC(C)(C)C(C)(C)O2)cc1)C1CC1",
        "output": "942"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNC1.COc1ccc(S(=O)(=O)Cl)cc1C(=O)O.O>>COc1ccc(S(=O)(=O)N2CCCC2)cc1C(=O)O",
        "output": "99"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC=C(c2cccc(N)c2)CC1.CCO.[Pd]>>CC(C)(C)OC(=O)N1CCC(c2cccc(N)c2)CC1",
        "output": "806"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.O=C(O)Cc1cc(Cl)cc2c(-c3ccccc3)onc12>>O=C(Cc1cc(Cl)cc2c(-c3ccccc3)onc12)N1CCOCC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1cn(S(=O)(=O)c2cccnc2)c2cc(Br)ccc12.COc1ccc(B(O)O)cc1.Cc1ccccc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cn(S(=O)(=O)c2cccnc2)c2cc(-c3ccc(OC)cc3)ccc12",
        "output": "909"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CI.C[C@@H]1CN([C@@H](CO)c2ccccc2)CCN1.N.[H-].[Na+]>>COC[C@@H](c1ccccc1)N1CCN[C@H](C)C1",
        "output": "140"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCOCCOCCOCCOCCO1.CC#N.CCC(C)Oc1cc(O)c2c(c1)OC(C)(C)CC2=O.CI.[Na]>>CCC(C)Oc1cc(OC)c2c(c1)OC(C)(C)CC2=O",
        "output": "62"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(C(O)C(Cl)(Cl)Cl)cc1.COc1ccc(O)cc1.O=P(O)(O)O.O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3>>COc1ccc(OC(c2ccc(OC)cc2)C(Cl)(Cl)Cl)cc1",
        "output": "342"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.ClCCl.ClI.Nc1ccc(C(F)(F)F)c(F)c1>>Nc1cc(F)c(C(F)(F)F)cc1I",
        "output": "466"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cc1cc2c(cc1Br)C(C(C)C)C(C)C2(C)C.Cc1cc2c(cc1[Mg]Br)C(C(C)C)C(C)C2(C)C.O=S(=O)(O)O.[Mg]>>Cc1cc2c(cc1C=O)C(C(C)C)C(C)C2(C)C",
        "output": "638"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=CNc1ccc(Br)cc1F.OB(O)c1ccc(C(F)(F)F)cc1>>O=CNc1ccc(-c2ccc(C(F)(F)F)cc2)cc1F",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(NS(=O)(=O)c2ccc(N3CCC(=O)CC3)cc2)cc1OC.CS(=O)(=O)Nc1cc(C(O)CN)ccc1O>>COc1ccc(NS(=O)(=O)c2ccc(N3CCC(NCC(O)c4ccc(O)c(NS(C)(=O)=O)c4)CC3)cc2)cc1OC",
        "output": "236"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC12CCC(=O)C=C1c1c(cc(OC)c(Cl)c1Cl)C2.CCC12CCC(=O)C=C1c1c(cc(OCC(=O)O)c(Cl)c1Cl)C2>>CCC12CCC(=O)C=C1c1c(cc(O)c(Cl)c1Cl)C2",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)[O-].CCCCCCCCCCCCc1ccc(Br)cc1.Cc1ccccc1.[K+].[Pd+2].c1ccc(Nc2ccccc2)cc1>>CCCCCCCCCCCCc1ccc(N(c2ccccc2)c2ccccc2)cc1",
        "output": "894"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)c1ccncc1.CN(CC(C(=O)Nc1ccc2cnccc2c1)c1ccc(CO)cc1)C(=O)OC(C)(C)C.Cc1ccc(C(=O)O)c(C)c1.ClCCCl.c1ccncc1>>Cc1ccc(C(=O)OCc2ccc(C(CN(C)C(=O)OC(C)(C)C)C(=O)Nc3ccc4cnccc4c3)cc2)c(C)c1",
        "output": "33"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1cc2cc([N+](=O)[O-])ccc2[nH]1.CCOC(C)=O.O=C[O-].[NH4+].[Pd]>>CCOC(=O)c1cc2cc(N)ccc2[nH]1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O=CCC1CCC(C(=O)OCc2ccccc2)CC1.[BH4-].[Na+]>>O=C(OCc1ccccc1)C1CCC(CCO)CC1",
        "output": "223"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.COc1ncc(-c2nc(NC(=O)C3(c4ccc5c(c4)COC5)CC3)ccc2C)cc1C.C[Si](C)(C)I.ClCCl>>Cc1ccc(NC(=O)C2(c3ccc4c(c3)COC4)CC2)nc1-c1c[nH]c(=O)c(C)c1",
        "output": "758"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CCO.O=C([O-])[O-].OCCc1ccc(O)cc1.[K+].[K+]>>OCCc1ccc(OCc2ccccc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc(Nc2cccc(Cl)n2)ccc1-n1cnc(C)c1.Nc1ccc(C(F)(F)F)cc1>>COc1cc(Nc2cccc(Nc3ccc(C(F)(F)F)cc3)n2)ccc1-n1cnc(C)c1",
        "output": "434"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNCC1.CCO.Cc1cc(C(=O)NCCN2CCCC2)c(C=O)[nH]1.O=C1Cc2c(cccc2-c2cccc(C(F)(F)F)c2)N1>>Cc1cc(C(=O)NCCN2CCCC2)c(C=C2C(=O)Nc3cccc(-c4cccc(C(F)(F)F)c4)c32)[nH]1",
        "output": "440"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(CCOc1ncc(Br)cc1C(F)(F)F)C(=O)OC(C)(C)C.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CN(CCOc1ncc(B2OC(C)(C)C(C)(C)O2)cc1C(F)(F)F)C(=O)OC(C)(C)C",
        "output": "943"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)Cc1ccccc1-3.Cl.[Na+].[OH-]>>O=C(O)c1ccc2c(C3CCCCC3)c3n(c2c1)Cc1ccccc1-3",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COC(=O)c1cc(CO)nn1-c1ncccc1Cl.CS(=O)(=O)Cl.ClCCl>>COC(=O)c1cc(COS(C)(=O)=O)nn1-c1ncccc1Cl",
        "output": "0"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCCCCCCC(=O)Cl.CCN(CC)CC.COc1cccc(-c2n[nH]c(-c3ccccc3CO)n2)c1.O.O=C([O-])O.[Na+]>>CCCCCCCC(=O)OCc1ccccc1-c1nc(-c2cccc(OC)c2)n[nH]1",
        "output": "126"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.O=[N+]([O-])C1COc2c(Br)cccc2C1.[Zn]>>NC1COc2c(Br)cccc2C1",
        "output": "226"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.Cc1ncc(-c2cccc(N)c2)n1C.Clc1cc(-c2ccccc2)ncn1.O=C([O-])[O-].[K+].[K+]>>Cc1ncc(-c2cccc(Nc3cc(-c4ccccc4)ncn3)c2)n1C",
        "output": "161"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.N#Cc1ccc(Cl)cc1.NO.O.O=C([O-])[O-].[Cl-].[Na+].[Na+].[Na+]>>N=C(NO)c1ccc(Cl)cc1",
        "output": "854"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCCCCCBr.CCOCC.CN(C)C=O.Cl.O.O=C([O-])[O-].Oc1ccc2cc(O)ccc2c1.[K+].[K+]>>CCCCCCCCCCOc1ccc2cc(O)ccc2c1",
        "output": "75"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.CCOC(=O)CN(CC(=O)OCC)Cc1ccc2cc([N+](=O)[O-])c3ccc(CN(CC(=O)OCC)CC(=O)OCC)nc3c2n1.O.O=C[O-].[NH4+].[Pd]>>CCOC(=O)CN(CC(=O)OCC)Cc1ccc2cc(N)c3ccc(CN(CC(=O)OCC)CC(=O)OCC)nc3c2n1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CSc1nc(=O)c(Cc2cnc(=O)[nH]c2)c[nH]1.NCCc1ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)cc1.c1ccncc1>>O=c1ncc(Cc2c[nH]c(NCCc3ccc(Oc4ccc(Cl)c(C(F)(F)F)c4)cc3)nc2=O)c[nH]1",
        "output": "101"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[C@]1(c2cc(N)ccc2F)N=C(N)OCC1(F)F.O=C(O)c1ncc(Cl)cc1F>>C[C@]1(c2cc(NC(=O)c3ncc(Cl)cc3F)ccc2F)N=C(N)OCC1(F)F",
        "output": "985"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)O.CCOC(=O)c1ccc(CCc2ccccc2)[nH]1.CO.[Na+].[OH-]>>O=C(O)c1ccc(CCc2ccccc2)[nH]1",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br.O.OCCCc1ccc(O)cc1>>Oc1ccc(CCCBr)cc1",
        "output": "224"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)OC(=O)n1nc(-c2cc3cc(C(O)c4ccccc4)ccc3n2C(=O)OC(C)(C)C)c2sccc21.ClCCl.O>>CC(C)(C)OC(=O)n1nc(-c2cc3cc(C(=O)c4ccccc4)ccc3n2C(=O)OC(C)(C)C)c2sccc21",
        "output": "59"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Cc1ccc(S(=O)(=O)Cl)cc1.O=C1CC(c2ccccc2)Cc2[nH]ccc21.[H-].[Na+]>>Cc1ccc(S(=O)(=O)n2ccc3c2CC(c2ccccc2)CC3=O)cc1",
        "output": "648"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCO.CCOC(=O)Cc1cn(CCc2ccc(OCc3ccccc3)cc2)nc1-c1ccccc1.[C].[Pd]>>CCOC(=O)Cc1cn(CCc2ccc(O)cc2)nc1-c1ccccc1",
        "output": "23"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1cnc2ccccc2c1.ClCCl.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1cc(Br)cc2ccccc21",
        "output": "262"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.O=Cc1ccc(Oc2ccccc2)cc1.[BH4-].[Na+]>>OCc1ccc(Oc2ccccc2)cc1",
        "output": "356"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Clc1cncc(Cl)n1.N[C@H]1CC[C@H](O)CC1.O=C([O-])[O-].[Cs+].[Cs+]>>O[C@@H]1CC[C@@H](Nc2cncc(Cl)n2)CC1",
        "output": "148"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1coc2c1C(=O)C(C)(C)CC2.CCOC(=O)c1coc2c1C(=O)C(C)(C)OC2>>CC1(C)OCc2occ(C(=O)O)c2C1=O",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN.COc1ccnc2[nH]cc(C(CC(=O)O)c3ccccc3)c12.ClCCl.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CNC(=O)CC(c1ccccc1)c1c[nH]c2nccc(OC)c12",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.Cc1cc(-c2nc3ccc(N)cc3c(=O)[nH]2)cc(C)c1OCCO.O=C([O-])[O-].[K+].[K+].c1ccncc1>>CC(=O)Nc1ccc2nc(-c3cc(C)c(OCCO)c(C)c3)[nH]c(=O)c2c1",
        "output": "6"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Cc1cc(C(=O)c2c[nH]c3ccccc3c2=O)ccn1.Fc1ccccc1CBr.[H-].[Na+]>>Cc1cc(C(=O)c2cn(Cc3ccccc3F)c3ccccc3c2=O)ccn1",
        "output": "528"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(B2OC(C)(C)C(C)(C)O2)c(C)n1.Nc1c2c(nc3c(Br)c(F)ccc13)CN(C1CCC1)C2=O>>COc1ccc(-c2c(F)ccc3c(N)c4c(nc23)CN(C2CCC2)C4=O)c(C)n1",
        "output": "967"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)Cc1ccncc1[N+](=O)[O-].CO.[Pd]>>CCOC(=O)Cc1ccncc1N",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CO.COC(=O)c1csc(C#CC2CC2)n1.Cl.[Na+].[OH-]>>O=C(O)c1csc(C#CC2CC2)n1",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)Br.CCOC(=O)c1sc(-c2ccc(O)c([N+](=O)[O-])c2)nc1C.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1sc(-c2ccc(OC(C)C)c([N+](=O)[O-])c2)nc1C",
        "output": "153"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.Cc1cc(Br)cc(C)c1N.Clc1nc(Cl)nc(Cl)n1>>Cc1cc(Br)cc(C)c1Nc1nc(Cl)nc(Cl)n1",
        "output": "592"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C.Cl.[Li+].[OH-]>>CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C(=O)Cl.CN(C)C=O.Cc1cccc2nc(SCc3ccc(C(=O)c4ccc(O)cc4)cc3)n(C)c(=O)c12.O=C([O-])[O-].[K+].[K+]>>Cc1cccc2nc(SCc3ccc(C(=O)c4ccc(OC(=O)N(C)C)cc4)cc3)n(C)c(=O)c12",
        "output": "425"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCCC[C@H]1CC(=O)O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CO.F[B-](F)(F)F.O.[Cl-].[Na+]>>COC(=O)C[C@@H]1CCCCN1C(=O)OC(C)(C)C",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#Cc1cccc([N+](=O)[O-])c1.CC(C)O.[H][H]>>C#Cc1cccc(N)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.NC(=O)c1ccc(Oc2ccc(CCC=O)cc2)nc1.Nc1ccccc1.[Na+].[Na+].[OH-]>>NC(=O)c1ccc(Oc2ccc(CCCNc3ccccc3)cc2)nc1",
        "output": "336"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOc1cncc(C2COc3c(cccc3C(=O)O)O2)c1.CN(C)C=O.O.O=C(n1ccnc1)n1ccnc1.[NH4+].[OH-]>>CCOc1cncc(C2COc3c(cccc3C(N)=O)O2)c1",
        "output": "358"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.COC(=O)C1CNCCC1=O.ClCCl>>COC(=O)C1CN(C(=O)OC(C)(C)C)CCC1=O",
        "output": "694"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1ccccc1.C1CCNCC1.Cc1ccccc1>>c1ccc(N2CCCCC2)cc1",
        "output": "294"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.O=C(C1CNC1)N1CCCN(C2CCC2)CC1.O=C(Cl)N1CCCCC1>>O=C(C1CN(C(=O)N2CCCCC2)C1)N1CCCN(C2CCC2)CC1",
        "output": "258"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Cc1ccc(C)n1-c1cc2[nH]c(=O)c(=O)n(CC(=O)O)c2cc1Cl.NCc1ccccc1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>Cc1ccc(C)n1-c1cc2[nH]c(=O)c(=O)n(CC(=O)NCc3ccccc3)c2cc1Cl",
        "output": "599"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCn1nc(-c2cccc(C(C)(C)N)c2)cc1Oc1ccc(C(F)(F)F)cc1.ClCCl.O=S(=O)(Cl)CC(F)(F)F>>CCn1nc(-c2cccc(C(C)(C)NS(=O)(=O)CC(F)(F)F)c2)cc1Oc1ccc(C(F)(F)F)cc1",
        "output": "742"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COC(=O)C(Cc1cccc(-c2cc(C(C)(C)S(C)(=O)=O)cc3cccnc23)c1)c1ccc(S(C)(=O)=O)cc1.Cl.O.[Li+].[OH-]>>CC(C)(c1cc(-c2cccc(CC(C(=O)O)c3ccc(S(C)(=O)=O)cc3)c2)c2ncccc2c1)S(C)(=O)=O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CCCC(F)(F)[C@@H]1N.CCN(C(C)C)C(C)C.CCOC(C)=O.CCc1sc(C(=O)O)cc1Br.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F>>CCc1sc(C(=O)N[C@@H]2[C@H](NC(=O)OC(C)(C)C)CCCC2(F)F)cc1Br",
        "output": "736"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1c2ccc(CC(=O)O)ccc-2c(C(=O)OCC)c1N.CCOP(=O)(CON)OCC.O=C(n1ccnc1)n1ccnc1>>CCOC(=O)c1c2ccc(CC(=O)NOCP(=O)(OCC)OCC)ccc-2c(C(=O)OCC)c1N",
        "output": "480"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(CC)(c1ccc(C#CCCCCC(=O)OC)c(C)c1)c1ccc(/C=C/C(O)(C(F)(F)F)C(F)(F)F)c(C)c1.CCOC(C)=O.CO.[Na+].[OH-]>>CCC(CC)(c1ccc(C#CCCCCC(=O)O)c(C)c1)c1ccc(/C=C/C(O)(C(F)(F)F)C(F)(F)F)c(C)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)C(F)(F)c1cc(Cl)ccc1OCC(C)C.N>>CC(C)COc1ccc(Cl)cc1C(F)(F)C(N)=O",
        "output": "432"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C1COCCO1.CCOC(=O)c1c[nH]c(=O)o1.CO.Cl.O.O.[Li]O>>O=C(O)c1c[nH]c(=O)o1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)N.ClCCl.O=C(O)c1cccc(S(=O)(=O)Cl)c1>>CC(C)(C)NS(=O)(=O)c1cccc(C(=O)O)c1",
        "output": "43"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1ccccc1.CCN(CC)CC.OB(O)c1cccc2ccccc12>>c1ccc(-c2cccc3ccccc23)cc1",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COCCCN1C(=O)CCc2ccc(COC3CN(C(=O)OC(C)(C)C)CCC3c3ccc(O)cc3)cc21.Cc1cn(CCCCBr)c2ccccc12>>COCCCN1C(=O)CCc2ccc(COC3CN(C(=O)OC(C)(C)C)CCC3c3ccc(OCCCCn4cc(C)c5ccccc54)cc3)cc21",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)NC[C@H]1CN(c2ccc(OCC3(OC(=O)CCC(=O)OCc4ccccc4)CCNCC3)c(F)c2)C(=O)O1.CCN(CC)CC.CN1CCCC1=O.C[Si](C)(C)Cl.O=C(O)c1cn(C2CC2)c2nc(Cl)c(F)cc2c1=O>>CC(=O)NC[C@H]1CN(c2ccc(OCC3(OC(=O)CCC(=O)OCc4ccccc4)CCN(c4nc5c(cc4F)c(=O)c(C(=O)O)cn5C4CC4)CC3)c(F)c2)C(=O)O1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CN(C)C=O.COCCCN1C(=O)COc2ccc(COC3CN(C(=O)OCc4ccccc4)CCC3c3ccc(OC4CNC4)cc3)cc21.Clc1nc2ccccc2s1.O.O.O=C([O-])[O-].[Cl-].[K+].[K+].[Na+]>>COCCCN1C(=O)COc2ccc(COC3CN(C(=O)OCc4ccccc4)CCC3c3ccc(OC4CN(c5nc6ccccc6s5)C4)cc3)cc21",
        "output": "558"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CNCCN1.COc1c(F)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12.CS(C)=O>>COc1c(N2CCNCC2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12",
        "output": "676"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc2c(c1)C(=O)CCC2.Cc1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C1CCCc2ccc(O)cc21",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.N#Cc1ccc(F)c(B(O)O)c1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(Br)c1.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>N#Cc1ccc(F)c(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2N2CC[C@@H](O)C2)c1",
        "output": "833"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)CC(CC)(CC)C(=O)OCC.CCO.CO.Cl.ClCCl.[Na+].[OH-]>>CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)CC(CC)(CC)C(=O)O",
        "output": "281"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CCN(CC)CC.CCOC(=O)Cl.ClC(Cl)Cl.Nc1c(Cl)cc(C(=CC(=O)O)c2ccc(Cl)cc2)cc1Cl>>Nc1c(Cl)cc(C(=CC(=O)N2CCOCC2)c2ccc(Cl)cc2)cc1Cl",
        "output": "517"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCc1cc(C#N)ccc1N(C)c1cc2c(cn1)ncn2C.ClCCl.NO.O>>CCc1cc(C(N)=NO)ccc1N(C)c1cc2c(cn1)ncn2C",
        "output": "400"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)CI.CN1CCCC1=O.Cc1c([N+](=O)[O-])ccc(O)c1Cl.O=C([O-])[O-].[K+].[K+]>>Cc1c([N+](=O)[O-])ccc(OCC(C)(C)C)c1Cl",
        "output": "198"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)[C@H](Cc1ccc(NC(=O)c2c(Cl)cccc2Cl)cc1)NC(=O)C1(Cc2ccc(OC)cc2)CCCCC1.[Na+].[OH-]>>COc1ccc(CC2(C(=O)N[C@@H](Cc3ccc(NC(=O)c4c(Cl)cccc4Cl)cc3)C(=O)O)CCCCC2)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.ClCCl.NN.O.O=C1c2ccccc2C(=O)N1CCc1ccc(N2C(=O)N(c3ccc(Cl)cc3Cl)Cc3cnc(Nc4ccccc4)nc32)cc1>>NCCc1ccc(N2C(=O)N(c3ccc(Cl)cc3Cl)Cc3cnc(Nc4ccccc4)nc32)cc1",
        "output": "242"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.CCOC(C)=O.Cc1nccc2c1c(=O)n(C)c1cc(OC[C@@H](N)CC(C)C)c(I)cc21.ClCCl.O=C1OC(=O)c2ccccc21>>Cc1nccc2c1c(=O)n(C)c1cc(OC[C@H](CC(C)C)N3C(=O)c4ccccc4C3=O)c(I)cc21",
        "output": "341"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.CN(C)c1ccncc1.COC(=O)c1cccnc1N.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)Cc1ccc(Cl)cc1Cl.c1ccncc1>>COC(=O)c1cccnc1NC(=O)Cc1ccc(Cl)cc1Cl",
        "output": "368"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C.NCCCn1ccnc1>>COc1cc(C(=O)NCCCn2ccnc2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CS(=O)(=O)c1ccc(CNC(=O)c2ccnc(F)c2)c(Cl)c1.Oc1ccc(F)cc1.[H-].[Na+]>>CS(=O)(=O)c1ccc(CNC(=O)c2ccnc(Oc3ccc(F)cc3)c2)c(Cl)c1",
        "output": "727"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)Cc1cc(C)c([N+](=O)[O-])cc1Cl.[BH4-].[Na+]>>COC(=O)Cc1cc(C)c(N)cc1Cl",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)C1(C=NOCc2ccccc2)CCCCC1.Cl.O.[Na+].[OH-]>>O=C(O)C1(C=NOCc2ccccc2)CCCCC1",
        "output": "361"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1cnc(C(F)(F)F)c(C)c1Sc1ccc(C(C)C)cc1.[Na+].[OH-]>>Cc1c(C(F)(F)F)ncc(C(=O)O)c1Sc1ccc(C(C)C)cc1",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCc1cccc(COc2nnc(Cl)c3ccccc23)n1>>CS(=O)(=O)OCc1cccc(COc2nnc(Cl)c3ccccc23)n1",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCC/C=C\\C/C=C\\CCCCCCCCOCC(CO)COCCCCCCCC/C=C\\C/C=C\\CCCCC.CCN(CC)CC.CS(C)=O.O=C(Cl)C(=O)Cl>>CCCCC/C=C\\C/C=C\\CCCCCCCCOCC(C=O)COCCCCCCCC/C=C\\C/C=C\\CCCCC",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(-c3cccc(Br)c3)o2)c1.CN(C)C=O.N#Cc1ccc(B(O)O)cc1.O=C([O-])[O-].[Na+].[Na+]>>CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(-c3cccc(-c4ccc(C#N)cc4)c3)o2)c1",
        "output": "837"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccc(S(=O)(=O)Cl)cc1.Cc1ccccc1.Fc1ccc2[nH]ccc2c1.O.O=S(=O)([O-])O.[Na+].[OH-]>>Cc1ccc(S(=O)(=O)n2ccc3cc(F)ccc32)cc1",
        "output": "648"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1Cc2cc(-c3ccc(-c4cncc(N)c4)s3)ccc2C1=O.COc1ccccc1S(=O)(=O)Cl>>COc1ccccc1S(=O)(=O)Nc1cncc(-c2ccc(-c3ccc4c(c3)CN(C)C4=O)s2)c1",
        "output": "554"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC#N.CC(C)N=C=NC(C)C.N#CCC(=O)O.NC1CC1.O>>N#CCC(=O)NC1CC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccccc1-c1ccccc1.CC#N.CC(=O)[O-].CC(=O)[O-].O.O=C(O)c1cccc(B(O)O)c1.O=C([O-])[O-].[K+].[K+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(O)c1cccc(-c2ccccc2-c2ccccc2)c1",
        "output": "837"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)CCCN1CC[C@@H](Oc2ccc(Cc3ccccc3)cc2)C1.N>>NC(=O)CCCN1CC[C@@H](Oc2ccc(Cc3ccccc3)cc2)C1",
        "output": "432"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.CC(C)c1cccc(N)c1O.CCOC(C)=O.O.O=C(Cl)CBr.O=C([O-])O.[Na+]>>CC(C)c1cccc(NC(=O)CBr)c1O",
        "output": "9"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)COc1ccc(S(=O)(=O)c2ccc(CCN(C[C@H](O)c3cccc(Cl)c3)C(=O)OC(C)(C)C)cc2)cc1.CO.N>>CC(C)(C)OC(=O)N(CCc1ccc(S(=O)(=O)c2ccc(OCC(N)=O)cc2)cc1)C[C@H](O)c1cccc(Cl)c1",
        "output": "163"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.N[C@@H]1C[C@H]1c1ccccc1.Nc1ccnc(N2CCC(=O)CC2)n1.[Na+]>>Nc1ccnc(N2CCC(N[C@@H]3C[C@H]3c3ccccc3)CC2)n1",
        "output": "236"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[O-].Cc1ccccc1.Cc1ccccc1Br.Cc1ccccc1N.Cl[Pd]Cl.[Fe+2].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1ccccc1Nc1ccccc1C",
        "output": "405"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1c(-c2ccccc2Cl)c2cccnc2[nH]c1=O.CI.CN(C)C=O.O.[H-].[Na+]>>CCOC(=O)c1c(-c2ccccc2Cl)c2cccnc2n(C)c1=O",
        "output": "570"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.Cl.Clc1nc2ccccc2[nH]1.O.O=C([O-])[O-].O=c1[nH]c(C2CNC2)nc2c1cnn2C1CCCCC1.[K+].[K+]>>O=c1[nH]c(C2CN(c3nc4ccccc4[nH]3)C2)nc2c1cnn2C1CCCCC1",
        "output": "36"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1cc(-c2ccccc2)cc(-c2ccccc2)c1.ClCCl.O=C(O)C(F)(F)F>>Nc1cc(-c2ccccc2)cc(-c2ccccc2)c1",
        "output": "782"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COc1nc(C)cc(O)c1C#N.ClC(Cl)Cl.ClP(Cl)(Cl)(Cl)Cl.O=P(Cl)(Cl)Cl>>COc1nc(C)cc(Cl)c1C#N",
        "output": "177"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN=C=NCCCN(C)C.ClCCl.NCC1(O)CCC(F)(F)CC1.O=C(O)c1cn(CC2CCO2)c2cccc(Cl)c12.On1nnc2ccccc21>>O=C(NCC1(O)CCC(F)(F)CC1)c1cn(CC2CCO2)c2cccc(Cl)c12",
        "output": "674"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.ICCCCI.O=C([O-])[O-].O=S1(=O)CCN(c2ccc(O)cc2)CC1.[Cs+].[Cs+]>>O=S1(=O)CCN(c2ccc(OCCCCI)cc2)CC1",
        "output": "198"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)C1CCCCc2c1ncn2C(c1ccccc1)(c1ccccc1)c1ccccc1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OCC1CCCCc2c1ncn2C(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "343"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.ClCCCl.O=P(Cl)(Cl)Cl.O=c1[nH]cnc2cc(SCc3ccccc3)ccc12>>Clc1ncnc2cc(SCc3ccccc3)ccc12",
        "output": "14"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)C(C)(C)NC(=O)c1ccc2ccccc2c1C#Cc1ccccc1.O.O.[Li]O>>CC(C)(NC(=O)c1ccc2ccccc2c1C#Cc1ccccc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN=C=N.CCOC(C)=O.COc1ccc(CCN)cc1OC.COc1cccc(CCC(=O)O)c1.Cl>>COc1cccc(CCC(=O)NCCc2ccc(OC)c(OC)c2)c1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCS(=O)(=O)Cl.COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCNCC3)c12.Cl.Cl>>CCS(=O)(=O)N1CCC(n2c(=O)n(-c3cccc(Cl)c3)c(=O)c3cnc4c(OC)cccc4c32)CC1",
        "output": "584"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CNCCc1cccc(C(=O)OC)c1.COC(=O)C(CCCCl)(c1ccc(OC)c(OC)c1)C(C)C>>COC(=O)c1cccc(CCN(C)CCCC(C(=O)OC)(c2ccc(OC)c(OC)c2)C(C)C)c1",
        "output": "138"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#CCNC(=O)OC(C)(C)C.C1CCOC1.CC(C)NC(C)C.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Fc1cccc(COc2ccc(Nc3ncnc4ccc(I)cc34)cc2Cl)c1.[Cu]I>>CC(C)(C)OC(=O)NCC#Cc1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1",
        "output": "664"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cn1c(S)nc2ccsc2c1=O.O.O.O=C(c1ccc(CBr)cc1)c1ccc(Cl)cc1Cl.[Na+].[OH-]>>Cn1c(SCc2ccc(C(=O)c3ccc(Cl)cc3Cl)cc2)nc2ccsc2c1=O",
        "output": "699"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1nnc(-c2ccccc2C(=O)N[C@H]2CCC[C@@H]2Nc2nc3ccc(F)cc3s2)o1.Cl.N[C@H]1CCC[C@@H]1Nc1nc2ccc(F)cc2s1.O=C(O)c1ccccc1-n1ccnn1>>O=C(N[C@H]1CCC[C@@H]1Nc1nc2ccc(F)cc2s1)c1ccccc1-n1ccnn1",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)CCc1ccc(-c2ccccc2F)s1.Cl.O.[Na+].[OH-]>>O=C(O)CCc1ccc(-c2ccccc2F)s1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)=O.CC1(C)Oc2ccc(Nc3nc(Cl)ncc3F)nc2NC1=O.CN1CCCC1=O.CO.CO.ClCCl.Nc1ccc2ccncc2c1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC1(C)Oc2ccc(Nc3nc(Nc4ccc5ccncc5c4)ncc3F)nc2NC1=O",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1ccc(F)cc1OC.OC1CCNCC1>>COC(=O)c1ccc(N2CCC(O)CC2)cc1OC",
        "output": "773"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCc1c(C)nn(Cc2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)c1C.Cl.O.[Na+].[OH-]>>Cc1nn(Cc2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)c(C)c1CCC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(Oc1cc(-n2cnc3cc(CO)ncc32)sc1C(N)=O)c1ccccc1C(F)(F)F.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(Oc1cc(-n2cnc3cc(COS(C)(=O)=O)ncc32)sc1C(N)=O)c1ccccc1C(F)(F)F",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.COC(=O)CCc1sc(Sc2ccc(O)cc2)nc1-c1ccccc1.Cc1oc(-c2ccccc2)nc1CCl.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)CCc1sc(Sc2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)nc1-c1ccccc1",
        "output": "760"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCCCCOC(=O)OCCCCCC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>CCCCCCCCCOC(=O)OCCCCCC(=O)O",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)Cl.ClCCl.NCCc1cccc(F)c1F.c1ccncc1>>COC(=O)NCCc1cccc(F)c1F",
        "output": "94"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COc1cc(-c2cc3nccc(-c4cnn(CC(=O)O)c4)c3o2)cc(OC)c1OC.O.O=S(Cl)Cl.[NH4+].[OH-]>>COc1cc(-c2cc3nccc(-c4cnn(CC(N)=O)c4)c3o2)cc(OC)c1OC",
        "output": "313"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "N#CCC(=O)O.OCCO>>N#CCC(=O)OCCO",
        "output": "47"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(Br)cn1.CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)ccn1.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(B2OC(C)(C)C(C)(C)O2)cn1",
        "output": "943"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1cccc(-n2cccc2)c1.CCOCC.O.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1cccc(-n2cccc2)c1",
        "output": "311"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CC(=O)O)Cc1ccccc1.CCN(C(C)C)C(C)C.CCOC(=O)C(C#N)=NOC(N1CCOCC1)=[N+](C)C.COc1ccc(C2=NN(C3CCNCC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+]>>COc1ccc(C2=NN(C3CCN(C(=O)C[C@@H](Cc4ccccc4)NC(=O)OC(C)(C)C)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)c1cc(OC)c([N+](=O)[O-])cc1Cl.[BH4-].[Cl-].[Li+].[NH4+]>>COc1cc(CO)c(Cl)cc1[N+](=O)[O-]",
        "output": "444"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(c1ccc(-c2ccccc2)c(F)c1)c1csc(N)n1.CCN(CC)CC.O=C(Cl)c1ccccc1>>CC(c1ccc(-c2ccccc2)c(F)c1)c1csc(NC(=O)c2ccccc2)n1",
        "output": "673"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COc1ccc(O)cc1.C[Si](C)(C)Cl.ClCCl>>COc1ccc(O[Si](C)(C)C)cc1",
        "output": "746"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrC(Br)(Br)Br.OCC1CCCCCC1>>BrCC1CCCCCC1",
        "output": "378"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CC(=O)Cl.CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.ClCCl.[Cl-].[NH4+]>>C=CC(=O)N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "135"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc2[nH]c(C(=O)O)c(CCNC(=O)OC(C)(C)C)c2c1.Cl.F[P-](F)(F)(F)(F)F>>CNC(=O)c1[nH]c2ccc(OC)cc2c1CCNC(=O)OC(C)(C)C",
        "output": "137"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "NCCCN1CCCCC1.O=C(O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(F)cc2Cl)cc1>>O=C(NCCCN1CCCCC1)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(F)cc2Cl)cc1",
        "output": "835"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(OCCc2ccsc2)cc(OC(C)C)c1.[Na+].[OH-]>>CC(C)Oc1cc(OCCc2ccsc2)cc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)CC1CCC(C#N)(c2ccc(OC)c3c2OCCO3)CC1.CCOC(C)=O.O.[Na+].[OH-]>>COc1ccc(C2(C#N)CCC(CC(=O)O)CC2)c2c1OCCO2",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrP(Br)Br.COc1cccc(CO)c1.ClCCl.O>>COc1cccc(CBr)c1",
        "output": "300"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COc1nc2ccc(C(O)c3ccc(C)nc3C)cc2c(Cl)c1Cc1ccc(F)cc1.N#N.O=[Mn]=O>>COc1nc2ccc(C(=O)c3ccc(C)nc3C)cc2c(Cl)c1Cc1ccc(F)cc1",
        "output": "852"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(CC)CN.CCN(C(C)C)C(C)C.CCn1ncc2c(N[C@@H](C)C(C)C)c(C(=O)O)cnc21.CN(C)C=O.ClCCCl>>CCC(CC)CNC(=O)c1cnc2c(cnn2CC)c1N[C@@H](C)C(C)C",
        "output": "674"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCC(C(=O)OC)c1c(C)nc2sc(C)c(CC)c2c1-c1ccc(C)cc1.CCO.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc2sc(C)c(CC)c2c1-c1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccccc1.O=[N+]([O-])c1cnc(Cl)c([N+](=O)[O-])c1.OCCO.[Cl-].[H-].[NH4+].[Na+]>>O=[N+]([O-])c1cnc(OCCO)c([N+](=O)[O-])c1",
        "output": "433"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.Nc1ccnc(Br)c1.OCC(F)(F)F.[H-].[Na+]>>Nc1ccnc(OCC(F)(F)F)c1",
        "output": "551"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=O.CO.Cl.ClCCl.Nc1ccc(-c2cn(C3CCC4(CC3)OCCO4)c3ncnc(N)c23)cc1F>>Nc1ccc(-c2cn(C3CCC(=O)CC3)c3ncnc(N)c23)cc1F",
        "output": "251"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CO.Cc1ccc(F)cc1C(=O)O.Cl>>COC(=O)c1cc(F)ccc1C",
        "output": "195"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCOC(=O)C(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1.CO.[Na+].[OH-]>>CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1",
        "output": "615"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC[C@H](C)[C@H](NC(=O)c1sc(-c2ccc(OC)cc2)cc1NC(=O)Nc1c(C)cc(C)cc1C)C(=O)OC.[Li+].[OH-]>>CC[C@H](C)[C@H](NC(=O)c1sc(-c2ccc(OC)cc2)cc1NC(=O)Nc1c(C)cc(C)cc1C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Cc1cc(C)cc(C(N)=O)c1.O=S(Cl)Cl.[Na+].[OH-].c1ccccc1>>Cc1cc(C)cc(C#N)c1",
        "output": "374"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.O.[K+].[N-]=[N+]=N[C@H]1CCc2cc(Br)ccc21.[OH-].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N[C@H]1CCc2cc(Br)ccc21",
        "output": "562"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.COC(=O)c1cscc1NC(=O)COc1ccc(-c2ccc(F)cc2)cc1.[Na+].[OH-]>>O=C(COc1ccc(-c2ccc(F)cc2)cc1)Nc1cscc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(C=O)cc1O.ClCC1CC1.O=C([O-])[O-].[K+].[K+]>>COc1ccc(C=O)cc1OCC1CC1",
        "output": "74"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)Nc1cc(-c2cccs2)c([N+](=O)[O-])c(N)n1.CCOC(C)=O.ClCCl.[BH4-].[C].[Cl-].[NH4+].[Na+].[Pd]>>CCOC(=O)Nc1cc(-c2cccs2)c(N)c(N)n1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)CC1(CC(=O)O)CC(=O)N(CCc2ccccc2)C1=O.CN1CCOCC1.Cl.ClCCl.NOCc1ccccc1.O=C(n1ccnc1)n1ccnc1>>CC(C)CC1(CC(=O)NOCc2ccccc2)CC(=O)N(CCc2ccccc2)C1=O",
        "output": "480"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "N#Cc1ccccc1Br.O=C1CCN(c2ccc3nnc(C(F)(F)F)n3n2)CC1>>N#Cc1ccccc1C1(O)CCN(c2ccc3nnc(C(F)(F)F)n3n2)CC1",
        "output": "321"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(COCc1ccccc1)CC1(O)CCC2(CC1)OCCO2.O=CO.[H][H].[Pd]>>CC(C)(CO)CC1(O)CCC2(CC1)OCCO2",
        "output": "178"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(c2ccc(N)cc2)C1.CCN(CC)CC.O=C(Cl)Cc1ccccc1>>CC(C)(C)OC(=O)N1CCC(c2ccc(NC(=O)Cc3ccccc3)cc2)C1",
        "output": "9"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.O=C(O)c1cccc(S(=O)(=O)Cl)c1>>O=S(=O)(Cl)c1cccc(CO)c1",
        "output": "72"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.CON=C(CO)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1.Fc1ccc(CBr)c(F)c1.[H-].[Na+]>>CON=C(COCc1ccc(F)cc1F)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1",
        "output": "464"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.NCc1cccc(Oc2cccc(F)c2)c1.Nc1ncccc1C(=O)O.O=C([O-])O.On1nnc2ccccc21.[Na+]>>Nc1ncccc1C(=O)NCc1cccc(Oc2cccc(F)c2)c1",
        "output": "790"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.O.O=CC1c2ccccc2-c2ccc(C(=O)O)cc21.[BH4-].[Na+]>>O=C(O)c1ccc2c(c1)C(CO)c1ccccc1-2",
        "output": "223"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCOC(=O)c1cc(C#N)c(N2CC(C(=O)NS(=O)(=O)Cc3ccccc3)C2)nc1C(F)F.O.O=CO.[Na+].[OH-]>>N#Cc1cc(C(=O)O)c(C(F)F)nc1N1CC(C(=O)NS(=O)(=O)Cc2ccccc2)C1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)C1(CC2CC2)CCN(C(=O)OC(C)(C)C)C1.O.[K+].[OH-]>>CC(C)(C)OC(=O)N1CCC(CC2CC2)(C(=O)O)C1",
        "output": "361"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)O.COc1cc2c(nc(CO[Si](C)(C)C(C)(C)C)n2C)c(OC)c1OC.COc1cc2nc(CO[Si](C)(C)C(C)(C)C)n(C)c2c(OC)c1OC.O.O.O=C([O-])[O-].[Cl-].[K+].[K+].[Na+]>>COc1cc2c(nc(CO)n2C)c(OC)c1OC",
        "output": "708"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.ClCCl.OCCCCCCCCCBr>>O=CCCCCCCCCBr",
        "output": "142"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.ClC(Cl)Cl.NCCCBr.O=Cc1ccccc1.O=S(=O)([O-])[O-].[Mg+2]>>BrCCCN=Cc1ccccc1",
        "output": "52"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)CCOc1ccc(C#N)cn1.Cl>>CC(C)(C)CCOc1ccc(CN)cn1",
        "output": "560"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN1CCOCC1.COc1ccc(SCC(=O)O)cc1OC.Cl.ClCCl.Oc1c(F)c(F)c(F)c(F)c1F>>COc1ccc(SCC(=O)Oc2c(F)c(F)c(F)c(F)c2F)cc1OC",
        "output": "108"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1cc(Br)cc2c(C3CC(C)S(=O)(=O)C(C)C3)c[nH]c12.CO.O.[Na+].[OH-]>>CC1CC(c2c[nH]c3c(C(=O)O)cc(Br)cc23)CC(C)S1(=O)=O",
        "output": "5"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)[Si](OC1CCN(C2CCNC2=O)CC1)(c1ccccc1)c1ccccc1.Clc1cc(OCc2ccccc2)cc(Cl)c1CBr.[Li]CCCC>>CC(C)(C)[Si](OC1CCN(C2CCN(Cc3c(Cl)cc(OCc4ccccc4)cc3Cl)C2=O)CC1)(c1ccccc1)c1ccccc1",
        "output": "774"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCNCC1.O=c1[nH]c(Cl)cc2ccc3ccccc3c12>>CN1CCN(c2cc3ccc4ccccc4c3c(=O)[nH]2)CC1",
        "output": "220"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN=C=NCCCN(C)C.Nc1cc(C(F)(F)F)ccc1O.O=C(O)c1ccncc1F.c1ccncc1>>O=C(Nc1cc(C(F)(F)F)ccc1O)c1ccncc1F",
        "output": "50"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC/C=C/c1ccc2c(c1)C(C)(C)C(=O)C(C(=O)NCC(=O)OC(C)(C)C)=C2O.O=C(O)C(F)(F)F>>COC/C=C/c1ccc2c(c1)C(C)(C)C(=O)C(C(=O)NCC(=O)O)=C2O",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.COc1cnc(C(O)Cc2c(Cl)cncc2Cl)cc1OC1CCCC1.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl>>COc1cnc(C(=O)Cc2c(Cl)cncc2Cl)cc1OC1CCCC1",
        "output": "456"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)CN1C(=O)CCc2cc([N+](=O)[O-])ccc21.O.O=C[O-].[Fe].[NH4+]>>CCOC(=O)CN1C(=O)CCc2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.NCCN.S=C=Nc1cccc2[nH]cc(Cl)c12>>NCCNC(=S)Nc1cccc2[nH]cc(Cl)c12",
        "output": "113"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OB(c2ccc(F)cc2)OC1(C)C.COC(=O)c1cc(C)ccc1-c1cnn(C)c1.Cc1ccc(Br)c(C#N)n1>>Cc1ccc(-c2ccc(F)cc2)c(C#N)n1",
        "output": "938"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CS(=O)(=O)Cl.OCC1(CC#Cc2ccc(OC(F)(F)F)cc2)CCC1>>CS(=O)(=O)OCC1(CC#Cc2ccc(OC(F)(F)F)cc2)CCC1",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)C[Al+]CC(C)C.COC(=O)c1cccnc1C.ClCCl.O=C([O-])[C@H](O)[C@@H](O)C(=O)[O-].[H-].[K+].[Na+]>>Cc1ncccc1CO",
        "output": "522"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCC2=NCCCN2CC1.COCCOC.N#Cc1c(Cl)nc(N)nc1OCc1ccccn1.O.OCc1ccccn1>>N#Cc1c(OCc2ccccn2)nc(N)nc1OCc1ccccn1",
        "output": "653"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=[N+]([O-])C1([N+](=O)[O-])CC(c2ccc(O)c(-c3ccccc3)c2)=CC(c2ccccc2)=C1O.O=[N+]([O-])c1cc(-c2cc(-c3ccccc3)c(O)c([N+](=O)[O-])c2)cc(-c2ccccc2)c1O.[H][H]>>Nc1cc(-c2cc(N)c(O)c(-c3ccccc3)c2)cc(-c2ccccc2)c1O",
        "output": "204"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)c2ccncc2)CC1.Cl.ClCCl.O=C([O-])[O-].[K+].[K+]>>O=C(c1ccncc1)N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CN.O=C(OCc1ccccc1)c1cc(Cl)cc(OCCCON2C(=O)c3ccccc3C2=O)c1>>NOCCCOc1cc(Cl)cc(C(=O)OCc2ccccc2)c1",
        "output": "452"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1CN(c2ccc3[nH]c(-c4nn(C5CCCCO5)c5ccc([N+](=O)[O-])cc45)nc3c2)CCO1.CCO.[H][H].[Pd]>>CC1CN(c2ccc3[nH]c(-c4nn(C5CCCCO5)c5ccc(N)cc45)nc3c2)CCO1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1ncc(-c2ccc(S(C)(=O)=O)cc2)o1.[Na+].[OH-]>>CS(=O)(=O)c1ccc(-c2cnc(C(=O)O)o2)cc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CNCCN1.CC#N.Clc1nncc2cc(Br)ccc12.O=C([O-])[O-].[K+].[K+]>>Brc1ccc2c(N3CCNCC3)nncc2c1",
        "output": "406"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COC(=O)c1cccc(CN2CN(c3ccc(F)cc3)C3(CCN(C(=O)OC(C)(C)C)CC3)C2=O)c1.Cl>>COC(=O)c1cccc(CN2CN(c3ccc(F)cc3)C3(CCNCC3)C2=O)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.CCN1C(=O)C(F)(F)CN(C2CCCC2)c2nc(Cl)ncc21.CN1CCC(NC(=O)c2ccc(N)cc2)CC1.Cc1ccc(S(=O)(=O)O)cc1.O>>CCN1C(=O)C(F)(F)CN(C2CCCC2)c2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3)ncc21",
        "output": "941"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(-c2ccc(Cl)cc2Cl)nc1CC.CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1N[C@@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1O.FCCBr>>CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1N[C@@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1OCCF",
        "output": "95"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)[Si](OCCOc1cc(CCl)ccc1Br)(C(C)C)C(C)C.CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.COCCO.O=C([O-])O.[H-].[I-].[Na+].[Na+]>>COCCOCc1ccc(Br)c(OCCO[Si](C(C)C)(C(C)C)C(C)C)c1",
        "output": "208"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCc1nc(SCCCC(=O)OCC)sc1Cc1ccc([N+](=O)[O-])cc1.CCO.O.[Ni]>>CCCc1nc(SCCCC(=O)OCC)sc1Cc1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(Br)nc1Br.O=C([O-])[O-].O=S(=O)(O)O.O=[N+]([O-])O.[Na+].[Na+]>>COc1cc([N+](=O)[O-])c(Br)nc1Br",
        "output": "328"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.CC(C)OP(=O)(OC(C)C)c1ccc([N+](=O)[O-])cc1.[H][H].[Pd]>>CC(C)OP(=O)(OC(C)C)c1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCC1CC1.CO.Nc1ncccc1-c1cc(Cc2ccc(O)cc2)no1.[I-].[Na+].[Na+].[OH-]>>Nc1ncccc1-c1cc(Cc2ccc(OCC3CC3)cc2)no1",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Oc1ccc(C(=O)O)cc1.O=S(Cl)Cl>>CC(=O)Oc1ccc(C(=O)Cl)cc1",
        "output": "3"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CO.COc1ccc(N2CCOCC2)c2sc(N)nc12.O=C(Cl)C1CCOCC1>>COc1ccc(N2CCOCC2)c2sc(NC(=O)C3CCOCC3)nc12",
        "output": "553"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(c1ccc(C#N)c(Cl)n1)[C@@H]1CCN(C(=O)OC(C)(C)C)C1.CO.C[O-].[Na+]>>COc1nc(N(C)[C@@H]2CCN(C(=O)OC(C)(C)C)C2)ccc1C#N",
        "output": "433"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=C(O)CCc1cnoc1-c1ccc(Cl)c(Cl)c1.O=S(=O)(O)O>>COC(=O)CCc1cnoc1-c1ccc(Cl)c(Cl)c1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cl.Cl.N[C@H]1CN2CCC1CC2.O=C(O)/C=C/c1ccoc1>>O=C(/C=C/c1ccoc1)N[C@H]1CN2CCC1CC2",
        "output": "767"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.COC(OC)C(CNC(=O)c1cc2cc(OC(F)(F)F)cc(N(C)S(=O)(=O)c3cccs3)c2[nH]1)SCc1ccccc1.O>>CN(c1cc(OC(F)(F)F)cc2cc(C(=O)NCC(C=O)SCc3ccccc3)[nH]c12)S(=O)(=O)c1cccs1",
        "output": "234"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.Cc1cc([N+](=O)[O-])c2[nH]c(-c3ccccc3)cc2c1>>Cc1cc([N+](=O)[O-])c2c(c1)cc(-c1ccccc1)n2C(=O)OC(C)(C)C",
        "output": "748"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.Cl[Sn]Cl.Nc1ccc(F)c(F)c1F.O=N[O-].[Na+]>>NNc1ccc(F)c(F)c1F",
        "output": "109"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.C1=CCCCC1.C=CCn1nc(-c2ccc(OC)cc2)c2cccc(C(F)(F)F)c21>>C=CCn1nc(-c2ccc(O)cc2)c2cccc(C(F)(F)F)c21",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1ccccc1.CC1(C)OB(c2ccc(OC(=O)N3CCN4CCC3CC4)cc2)OC1(C)C.ClCCl.Cl[Pd]Cl.O=P([O-])([O-])[O-].[Fe+2].[Fe+2].[K+].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=C(Oc1ccc(-c2ccccc2)cc1)N1CCN2CCC1CC2",
        "output": "933"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)C1CCCC2CCNCC21.Cl.ClCCl.O=C(O)CCc1ccc(F)cc1>>CCOC(=O)C1CCCC2CCN(C(=O)CCc3ccc(F)cc3)CC21",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1sccc1-c1ncon1.O=C(O)Cn1c(=O)ccc2cc(F)c(F)cc21>>O=C(Cn1c(=O)ccc2cc(F)c(F)cc21)Nc1sccc1-c1ncon1",
        "output": "882"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.ClC(Cl)Cl.NCC1CCOC1.O=C(O)c1cc(COCc2cc(F)c(F)c(F)c2)on1.On1nnc2ccccc21>>O=C(NCC1CCOC1)c1cc(COCc2cc(F)c(F)c(F)c2)on1",
        "output": "696"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)O.CCOC(=O)c1cc2ccc(C#N)cc2n1CC.O.O=C([O-])O.[BH4-].[Ca+2].[I-].[I-].[Na+].[Na+]>>CCn1c(CO)cc2ccc(C#N)cc21",
        "output": "711"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)N1CCC(Cn2c(CC(C)(C)C)nc3cc(S(=O)(=O)C4CN(C(=O)OC(C)(C)C)C4)ccc32)CC1.ClCCl.O=C(O)C(F)(F)F>>CC(=O)N1CCC(Cn2c(CC(C)(C)C)nc3cc(S(=O)(=O)C4CNC4)ccc32)CC1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.COc1cc2c(C)cccc2cc1C(C)C.ClCCl>>Cc1cccc2cc(C(C)C)c(O)cc12",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)Oc1cccc(-c2ccnc(Cl)n2)c1.COc1cc(CCN)ccc1O>>COc1cc(CCNc2nccc(-c3cccc(OC(C)C)c3)n2)ccc1O",
        "output": "544"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.COc1cc2ncnc(Cl)c2cc1OC.Nc1ccc(I)cc1>>COc1cc2ncnc(Nc3ccc(I)cc3)c2cc1OC",
        "output": "352"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.O.O=C(OCc1ccccc1)N1CCNCC1>>CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COC[C@H](C)Oc1cc(Oc2ccc(C(=O)N3CCC3)cc2F)cc(-c2ccc(C(=O)OCc3ccccc3)[nH]2)c1.[C].[Pd]>>COC[C@H](C)Oc1cc(Oc2ccc(C(=O)N3CCC3)cc2F)cc(-c2ccc(C(=O)O)[nH]2)c1",
        "output": "291"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "N#Cc1cc(CO)ccc1Oc1ccc(Cl)c(C(F)(F)F)c1.O=c1nc(Cl)cc2n1CCCN2C1CC1>>N#Cc1cc(COc2cc3n(c(=O)n2)CCCN3C2CC2)ccc1Oc1ccc(Cl)c(C(F)(F)F)c1",
        "output": "653"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN(c1cncc(C(=O)O)c1C)C1CCOCC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(C)c(CN)c(=O)[nH]1.F[P-](F)(F)(F)(F)F.O>>CCN(c1cncc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1",
        "output": "674"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "N#Cc1ccc(Nc2nc(N)cc(O)n2)cc1.O.O=C([O-])[O-].O=P(Cl)(Cl)Cl.[K+].[K+]>>N#Cc1ccc(Nc2nc(N)cc(Cl)n2)cc1",
        "output": "25"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN1CCN(c2nc(C)nc3c2nc(-c2ccccc2Cl)n3CCNC(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>CCN1CCN(c2nc(C)nc3c2nc(-c2ccccc2Cl)n3CCN)CC1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Oc1cccc(C=O)c1.CCCCCC.CSc1ccc(Br)cc1.[Li]CCCC>>CSc1ccc(C(O)c2cccc(O[Si](C)(C)C(C)(C)C)c2)cc1",
        "output": "379"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOC(C)=O.CN(C)C=O.OB(O)c1ccc(O)cc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1ccc(B(O)O)cc1",
        "output": "746"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "B.CC(=O)O.CO.C[Si](C)(C)CCOCn1ccc2c1ncc1c(=O)ccn(C3CCNCC3)c12.Cc1ccccn1.O=Cc1ccc(Cl)s1>>C[Si](C)(C)CCOCn1ccc2c1ncc1c(=O)ccn(C3CCN(Cc4ccc(Cl)s4)CC3)c12",
        "output": "792"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)c1c(N)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2n(C)c1=O.COCC(=O)Cl.[H-].[Na+]>>COCC(=O)Nc1c(C(C)=O)c(=O)n(C)c2nc(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)cc12",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCC.CO.C[Si](C)(C)C=[N+]=[N-].O=C(O)CC1C2CCC1CC2>>COC(=O)CC1C2CCC1CC2",
        "output": "195"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCc1nc2c(C)cc(N(C)C(=NC#N)N(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)OC)cc1.[Na+].[OH-]>>CCc1nc2c(C)cc(N(C)C(=NC#N)N(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.Nc1ncc(Br)c(Cl)c1[N+](=O)[O-].O=C(CN1CCNCC1)N1CCCC1>>Nc1ncc(Br)c(N2CCN(CC(=O)N3CCCC3)CC2)c1[N+](=O)[O-]",
        "output": "398"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(=O)c1ccc(N)cc1.CN(C)C=O.ClCCl.O=C(O)C(c1ccccc1)C1CCCCC1.O=S(Cl)Cl>>CCOC(=O)c1ccc(NC(=O)C(c2ccccc2)C2CCCCC2)cc1",
        "output": "710"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.C[O-].Clc1cc(Cl)nc(Cl)c1.[Na+]>>COc1cc(Cl)nc(Cl)c1",
        "output": "651"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C(c1ccc(F)cc1)N1CCC[C@H](O)C1.O=C=Nc1cccc(F)c1>>O=C(Nc1cccc(F)c1)O[C@H]1CCCN(C(=O)c2ccc(F)cc2)C1",
        "output": "34"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cc1ccc(C(=O)O)cc1[N+](=O)[O-].O=S(Cl)Cl>>COC(=O)c1ccc(C)c([N+](=O)[O-])c1",
        "output": "33"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.O=C1CCc2ccccc2N1CCN1CCCC1.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+].[Na+].[OH-]>>c1ccc2c(c1)CCCN2CCN1CCCC1",
        "output": "112"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CN(C)C=O.CN1CCOCC1.CN=C=O.Cl.ClCCl.NCc1ccc(-n2ccc(OCc3ccccc3)c(Br)c2=O)cc1>>CC(=O)NCc1ccc(-n2ccc(OCc3ccccc3)c(Br)c2=O)cc1",
        "output": "206"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)CCCn1c(Cl)nc2cccc(Br)c21.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1C.Nc1ccc(Cl)cc1Cl.O.O=C([O-])O.[Na+]>>CCOC(=O)CCCn1c(Nc2ccc(Cl)cc2Cl)nc2cccc(Br)c21",
        "output": "808"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CC(=O)[O-].CC(=O)[O-].CCCCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCO.CCOC(C)=O.COc1ccc(B(O)O)cc1.O.O=C([O-])[O-].O=C1CCc2cc(Br)ccc21.[Br-].[K+].[K+].[Pd+2]>>COc1ccc(-c2ccc3c(c2)CCC3=O)cc1",
        "output": "837"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CNCCN1.CC#N.N#Cc1ccc(Cl)c(F)c1.O=C([O-])[O-].[K+].[K+]>>N#Cc1ccc(N2CCNCC2)c(F)c1",
        "output": "105"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.Cc1cc(F)c(C(=O)O)cc1F.Cl.F[P-](F)(F)(F)(F)F.Nc1cccc(S(N)(=O)=O)c1>>Cc1cc(F)c(C(=O)Nc2cccc(S(N)(=O)=O)c2)cc1F",
        "output": "50"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CNC.COc1ccc(-c2nc(-c3cccc(C=O)c3)n(C(F)F)n2)cc1>>COc1ccc(-c2nc(-c3cccc(CN(C)C)c3)n(C(F)F)n2)cc1",
        "output": "567"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(Cl)Cl.CCCc1c(-c2nsc(Nc3ccccn3)n2)cnn1Cc1ccc(OC)cc1.CCCc1nn(Cc2ccc(OC)cc2)cc1-c1nsc(Nc2ccccn2)n1.O=C(O)C(F)(F)F>>CCCc1n[nH]cc1-c1nsc(Nc2ccccn2)n1",
        "output": "940"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=C(C)OC(=O)Nc1cc(C(F)(F)F)ccn1.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>C=C(C)OC(=O)Nc1cc(C(F)(F)F)cc[n+]1[O-]",
        "output": "262"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(C(C)=O)cn1.Cl.[Na+].[OH-]>>CC(=O)c1ccc(=O)[nH]c1",
        "output": "758"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c(S(=O)(=O)NC3CCCCC3)c2)cc2ccccc21.ClCCl>>O=S(=O)(NC1CCCCC1)c1cc(-c2cc3ccccc3[nH]2)ccc1Cl",
        "output": "848"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(C)(C)O)CC2)c2nc(C(F)(F)F)nn12.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(C)(C)O)CC2)c2nc(C(F)(F)F)nn12",
        "output": "979"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.CS(=O)(=O)OCCn1ccc2ccccc21.O.O=Cc1ccc(O)cc1.[H-].[Na+]>>O=Cc1ccc(OCCn2ccc3ccccc32)cc1",
        "output": "702"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=Cc1cncc(Br)c1.[BH4-].[Na+]>>OCc1cncc(Br)c1",
        "output": "476"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cn1ncc2cc(C(F)(F)F)cc(COCC3(c4ccccc4)CCN(C(=O)OC(C)(C)C)CC3)c21.O=C(O)C(F)(F)F>>Cn1ncc2cc(C(F)(F)F)cc(COCC3(c4ccccc4)CCNCC3)c21",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.Nc1ccc(Br)cn1.O.[Na+].[OH-]>>CC(=O)Nc1ccc(Br)cn1",
        "output": "368"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)C=O.Cc1cc(C#N)ccc1Br>>Cc1cc(C#N)ccc1C=O",
        "output": "638"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C[C@@H](NC(=O)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NC2CCC2)n(-c2ccccc2)n1)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>C[C@@H](NC(=O)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NC2CCC2)n(-c2ccccc2)n1)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.BrBr.CC(=O)O.CC(=O)c1cc(Cl)ccc1Cl.O=C([O-])[O-].O=S([O-])([O-])=S.[Na+].[Na+].[Na+].[Na+]>>O=C(CBr)c1cc(Cl)ccc1Cl",
        "output": "173"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#Cc1ccc(NC(=O)OC(C)(C)C)c(NC(=O)/C=C/c2ccc(NC(C)=O)cc2)c1.C1COCCO1.O=S(=O)(O)O>>C#Cc1ccc(N)c(NC(=O)/C=C/c2ccc(NC(C)=O)cc2)c1",
        "output": "782"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc([N+](=O)[O-])c(OC)cc1C.ClB(Cl)Cl.ClCCl.O=C([O-])O.[Na+]>>COc1cc([N+](=O)[O-])c(O)cc1C",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCCN2CCCCC2=O)c1=O.C[C@H](N)CO>>C[C@@H](CO)NC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCCN2CCCCC2=O)c1=O",
        "output": "498"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)O.CCN(C(C)C)C(C)C.CCOC(=O)C(C#N)=NOC(N1CCOCC1)=[N+](C)C.COc1ccc(C2=NN(C3CCNCC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+]>>COc1ccc(C2=NN(C3CCN(C(=O)[C@H](Cc4ccc(F)cc4)NC(=O)OC(C)(C)C)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)Oc1ccc(-c2nc(-c3cccc4c(CCC(=O)OC(C)(C)C)c[nH]c34)no2)cc1C#N.ClCCl.O=C(O)C(F)(F)F>>CC(C)Oc1ccc(-c2nc(-c3cccc4c(CCC(=O)O)c[nH]c34)no2)cc1C#N",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OC(c1cccc(Cl)c1)c1csc(C2OCCO2)c1.CCCCCC.CN(C)C=O.[Li]CCCC>>CC(C)(C)[Si](C)(C)OC(c1cccc(Cl)c1)c1cc(C2OCCO2)sc1C=O",
        "output": "617"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)[C@@H](Cc1ccccc1)Oc1c(C)cc(-c2c3ccccc3c(Br)c3sc(C)c(C)c23)cc1C.Cl.O.[K+].[OH-]>>Cc1cc(-c2c3ccccc3c(Br)c3sc(C)c(C)c23)cc(C)c1O[C@H](Cc1ccccc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.Cc1ccc(N)c(C)c1NC(=O)CCC1CCCC1.O=Cc1ccc(C(F)(F)F)cc1.[BH4-].[Na+]>>Cc1ccc(NCc2ccc(C(F)(F)F)cc2)c(C)c1NC(=O)CCC1CCCC1",
        "output": "359"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[P-](F)(F)(F)(F)F.Nc1cc(C#Cc2cnc3ccc(-c4ccc(C(=O)N5CCOCC5)cc4)nn23)ccn1.O.O=C(O)c1ccncc1>>O=C(Nc1cc(C#Cc2cnc3ccc(-c4ccc(C(=O)N5CCOCC5)cc4)nn23)ccn1)c1ccncc1",
        "output": "744"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)N(C)C.COCC(=O)Cl.Nc1c(I)c(C(=O)Cl)c(I)c(C(=O)Cl)c1I.O>>COCC(=O)Nc1c(I)c(C(=O)Cl)c(I)c(C(=O)Cl)c1I",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C1(Cc2cc(C)nc(Cl)c2)CCN(C(=O)OC(C)(C)C)CC1.CO.[H][H].[Pd]>>CCOC(=O)C1(Cc2ccnc(C)c2)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "40"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1cc(C=O)c(Cl)cc1O.Fc1cc(Cl)ccc1CBr.[H-].[Na+]>>COc1cc(C=O)c(Cl)cc1OCc1ccc(Cl)cc1F",
        "output": "127"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CBr.N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)O)(CC1)CC2>>CC(C)COC(=O)C12CCC(NCC(=O)N3C[C@@H](F)C[C@H]3C#N)(CC1)CC2",
        "output": "416"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CCNCC2)C1.CC(C)O.CCN(C(C)C)C(C)C.FC(F)(F)c1nccc(Cl)n1>>CC(C)(C)OC(=O)N1CCC2(CCN(c3ccnc(C(F)(F)F)n3)CC2)C1",
        "output": "162"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCCC.Cc1c(Br)ccc2c1OCCO2.O.O=C=O.[Li]CCCC>>Cc1c(C(=O)O)ccc2c1OCCO2",
        "output": "654"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Cc1cc(NC2CCN(C(=O)OC(C)(C)C)CC2)c([N+](=O)[O-])cc1C(F)(F)F.NN.O.[Ni]>>Cc1cc(NC2CCN(C(=O)OC(C)(C)C)CC2)c(N)cc1C(F)(F)F",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCC(=O)Cl.COc1cc(-c2ccnc3c(C(=O)N[C@@H]4CCNC[C@H]4O)c(C)[nH]c23)c(OCC2CC2)cc1F.Cl>>COCC(=O)N1CC[C@@H](NC(=O)c2c(C)[nH]c3c(-c4cc(OC)c(F)cc4OCC4CC4)ccnc23)[C@H](O)C1",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)C[AlH]CC(C)C.CCOC(=O)c1c(C)nc2c(ccn2Cc2ccc(F)c(F)c2)c1I.ClCCl.O.O.[Na+].[OH-]>>Cc1nc2c(ccn2Cc2ccc(F)c(F)c2)c(I)c1CO",
        "output": "383"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CO.CO.COC(=O)c1sc(-c2ccccc2)cc1N(CC1CCN(C(=O)OCc2ccccc2)CC1)C(=O)c1ccc(Cl)cc1Cl.O.O.[Li]O>>O=C(O)c1sc(-c2ccccc2)cc1N(CC1CCN(C(=O)OCc2ccccc2)CC1)C(=O)c1ccc(Cl)cc1Cl",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC(C)=CCCC(=CCBr)CC.Oc1ccc2c(c1)OCC2>>CCC(C)=CCCC(=CCOc1ccc2c(c1)OCC2)CC",
        "output": "77"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1cncc(Br)c1.CCOC(=O)C1CCNCC1.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)C1CCN(c2cncc(Br)c2)CC1",
        "output": "597"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCNCC2)c1.O=C(CCCCCl)c1ccc(C(F)(F)F)cc1.O=C([O-])[O-].[K+].[K+]>>CC(C)C(=O)Nc1cccc(C2CCN(CCCCC(=O)c3ccc(C(F)(F)F)cc3)CC2)c1",
        "output": "138"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(C)=O.N#CC1(c2cc(F)cc(F)c2)CCCCC1.O.O=C([O-])[O-].OO.[K+].[K+]>>NC(=O)C1(c2cc(F)cc(F)c2)CCCCC1",
        "output": "632"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#C[C@]1(O)CCN(C)C1=O.COC(=O)c1nn(-c2cc(Cl)cc(Br)c2)c2ncccc12>>COC(=O)c1nn(-c2cc(Cl)cc(C#C[C@]3(O)CCN(C)C3=O)c2)c2ncccc12",
        "output": "659"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCOC(=O)c1cc2sc(C#Cc3ccccc3)cc2n1Cc1cccc(Cl)c1.Cl.[K+].[OH-]>>O=C(O)c1cc2sc(C#Cc3ccccc3)cc2n1Cc1cccc(Cl)c1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNCC1.C1CCOC1.CCN(CC)CC.CCOC(C)=O.O=C(O)c1nc(-n2cnc3ccc(F)cc32)nc2c1[nH]c(=O)n2C1CCOCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(c1nc(-n2cnc3ccc(F)cc32)nc2c1[nH]c(=O)n2C1CCOCC1)N1CCCCC1",
        "output": "729"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1cc2c(ccn2S(C)(=O)=O)cc1F.ClCCl>>CS(=O)(=O)n1ccc2cc(F)c(O)cc21",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)Cc1cccc(Oc2ccccc2C)c1[N+](=O)[O-].CO.[K+].[OH-]>>Cc1ccccc1Oc1cccc(CC(=O)O)c1[N+](=O)[O-]",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1CCCC(C)(C(=O)O)C1.NNc1cccc2ncccc12>>CC1CCCC(C)(C(=O)NNc2cccc3ncccc23)C1",
        "output": "459"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(OC2CCN(C)CC2)c2c(Nc3ccc(O)c(C)c3)ncnc2c1.Fc1cccc(CCl)c1>>COc1cc(OC2CCN(C)CC2)c2c(Nc3ccc(OCc4cccc(F)c4)c(C)c3)ncnc2c1",
        "output": "49"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCc1ccc(C#C[Si](C)(C)C)cc1.CO.ClCCl.O=C([O-])[O-].[K+].[K+]>>C#Cc1ccc(CCCCCC)cc1",
        "output": "337"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cccc3c2OCCN3)CC1.O.O=[N+]([O-])c1cccc(S(=O)(=O)Cl)c1.c1ccncc1>>CC(C)(C)OC(=O)N1CCN(c2cccc3c2OCCN3S(=O)(=O)c2cccc([N+](=O)[O-])c2)CC1",
        "output": "791"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CNc1cc(-n2ccc(OCc3ccc(F)cc3)cc2=O)ccc1[N+](=O)[O-].[Zn]>>CNc1cc(-n2ccc(OCc3ccc(F)cc3)cc2=O)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)CC(=O)O.CN(C)C=O.O.O=C1Nc2ccc(Br)cc2C(=O)N2CCNCC12.On1nnc2ccccc21>>CC(C)(C)CC(=O)N1CCN2C(=O)c3cc(Br)ccc3NC(=O)C2C1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CCC(CC(=O)c1ccc(=O)[nH]c1)c1ccc(Br)cc1.CI.O=C([O-])[O-].[K+].[K+]>>C=CCC(CC(=O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1",
        "output": "191"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(NC(=O)OCc2ccccc2)(C(=O)O)CC1.CCN(CC)CC.CCOC(=O)Cl.CCOC(C)=O.O.[BH4-].[Na+]>>CC(C)(C)OC(=O)N1CCC(CO)(NC(=O)OCc2ccccc2)CC1",
        "output": "231"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CN(C)c1ccncc1.Cc1cccc(C(=O)O)c1.ClCCCl.NC(=O)n1c(-c2ccc(N)cc2)cc2ccccc21>>Cc1cccc(C(=O)Nc2ccc(-c3cc4ccccc4n3C(N)=O)cc2)c1",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CC(=O)Nc1cc(C)c(Oc2ccc(O)c(CC3CCOCC3)c2)c2c1CCC2.CO.[Na+].[OH-]>>Cc1cc(NC(=O)CC(=O)O)c2c(c1Oc1ccc(O)c(CC3CCOCC3)c1)CCC2",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1ccc(OC2CCCCO2)cn1.CC(C)(C)[O-].Cc1ccccc1.FC(F)(F)Oc1ccc(OCCC2CCNCC2)cc1.O.[Na+]>>FC(F)(F)Oc1ccc(OCCC2CCN(c3ccc(OC4CCCCO4)cn3)CC2)cc1",
        "output": "647"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCC(NC(=O)c2ccc([N+](=O)[O-])c3c2OCO3)CC1.CO>>CN1CCC(NC(=O)c2ccc(N)c3c2OCO3)CC1",
        "output": "28"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1c([N+](=O)[O-])ccnc1C(F)F.FC(F)(F)c1ccccc1.O.O=C1CCC(=O)N1Br>>O=[N+]([O-])c1ccnc(C(F)F)c1CBr",
        "output": "625"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.Ic1cnccc1OCCc1ccsc1.O=C(OO)c1cccc(Cl)c1.O=C([O-])[O-].[Na+].[Na+]>>[O-][n+]1ccc(OCCc2ccsc2)c(I)c1",
        "output": "262"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.O=C(O)COCC(=O)N1CCC(C(c2ccccc2)c2ccccc2)CC1.OCc1ccccc1>>O=C(COCC(=O)N1CCC(C(c2ccccc2)c2ccccc2)CC1)OCc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Clc1cc(-c2cccc(Br)c2)cnn1.O.[Na]>>CCOc1cc(-c2cccc(Br)c2)cnn1",
        "output": "407"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COc1cc(Br)cc(CC#N)c1.Cl.[Na+].[OH-]>>COc1cc(Br)cc(CCN)c1",
        "output": "246"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)C(N)=NO.N#CC1CCN(C(=O)N2CC(C(=O)O)CC(c3ccc(C(F)(F)F)cc3)C2)CC1>>CC(C)c1noc(C2CC(c3ccc(C(F)(F)F)cc3)CN(C(=O)N3CCC(C#N)CC3)C2)n1",
        "output": "728"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)O[K].CN(C)CCC1Cc2ccccc2C1O.O=C(c1ccccc1)c1ccccc1.c1ccccc1>>CN(C)CCC1Cc2ccccc2C1=O",
        "output": "32"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cc(Cl)cc(CO[Si](C)(C)C(C)(C)C)c1.ClCCl.[BH4-].[Na+]>>CC(C)(C)[Si](C)(C)OCc1cc(Cl)cc(CO)c1",
        "output": "444"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CN1C(=O)CCc2cc(B3OC(C)(C)C(C)(C)O3)ccc21.Cl[Pd]Cl.O=C([O-])[O-].OCc1cncc(Br)c1.[Na+].[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN1C(=O)CCc2cc(-c3cncc(CO)c3)ccc21",
        "output": "938"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.CN1CCOCC1.N[C@H]1CCN(Cc2ccccc2)C1.O.O=C(O)C(O)(c1ccccc1)C1CCCC1.On1nnc2ccccc21>>O=C(N[C@H]1CCN(Cc2ccccc2)C1)C(O)(c1ccccc1)C1CCCC1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOCC.O=C(NC1(C(=O)OCc2ccccc2)CCCCC1)c1cc2ccccc2s1.[Na+].[OH-]>>O=C(NC1(C(=O)O)CCCCC1)c1cc2ccccc2s1",
        "output": "186"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CS(=O)(=O)N1CC2CN(C(=O)OC(C)(C)C)CC2C1.CO.Cl>>C=CS(=O)(=O)N1CC2CNCC2C1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CCO.COC(=O)[C@H](O)CN1CCc2ccc(-c3noc(-c4ccc(OC(C)C)c(C#N)c4)n3)cc2CC1.O.[Na+].[OH-]>>CC(C)Oc1ccc(-c2nc(-c3ccc4c(c3)CCN(C[C@@H](O)C(=O)O)CC4)no2)cc1C#N",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)NCCc1ccccc1N.COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2O[C@H](C)C(=O)O)cc1>>COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2O[C@H](C)C(=O)Nc2ccccc2CCNC(C)=O)cc1",
        "output": "365"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.ClCCl.O=C1CCC2(CC1)Cc1ccc(OCCCF)cc1C2=O.[Cl-].[Na+]>>O=C1c2cc(OCCCF)ccc2CC12CCC(O)CC2",
        "output": "91"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)Cc1cccc(F)c1.O.O=S(=O)(O)O.O=[N+]([O-])O>>COC(=O)Cc1ccc([N+](=O)[O-])c(F)c1",
        "output": "21"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.c1ccc2c(c1)CCN2>>CC(C)(C)OC(=O)N1CCc2ccccc21",
        "output": "827"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1sc(NC(=N)N)nc1C.Cl.[Na+].[OH-]>>Cc1nc(NC(=N)N)sc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CI.CN(C(=O)OC(C)(C)C)C1=N[C@@H]2[C@@H](O)[C@H](O)[C@@H]([C@@H](O)C(F)(F)F)O[C@@H]2S1.CN(C)C=O.C[Si](C)(C)[N-][Si](C)(C)C.[Li+]>>CO[C@H]([C@H]1O[C@@H]2SC(N(C)C(=O)OC(C)(C)C)=N[C@@H]2[C@@H](O)[C@@H]1O)C(F)(F)F",
        "output": "140"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCCCO.O.O=C(O)c1cc(O)c(O)c(O)c1.O=S(=O)(O)O>>CCCCCCCCOC(=O)c1cc(O)c(O)c(O)c1",
        "output": "47"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)c1ccnc(Cl)c1N.CO.[BH4-].[Na+]>>CC(O)c1ccnc(Cl)c1N",
        "output": "24"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COC(=O)c1ccc2[nH]c(=S)oc2c1.O.[K+].[OH-]>>O=C(O)c1ccc2[nH]c(=S)oc2c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCBr.CC(C)=O.CCN(CC)CC.COC(=O)[C@@H]1C[C@H](O)CN1C(=O)OC(C)(C)C.O=[Ag]>>C=CCO[C@H]1C[C@@H](C(=O)OC)N(C(=O)OC(C)(C)C)C1",
        "output": "120"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CNCCCc1nc2ccccc2[nH]1.COC(=O)C(CCCBr)(c1ccc(Br)cc1)C(C)C.O=C([O-])[O-].[K+].[K+].c1ccc2[nH]cnc2c1>>COC(=O)C(CCCN(C)CCCc1nc2ccccc2[nH]1)(c1ccc(Br)cc1)C(C)C",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CCOC(=O)C1(CN=C(c2ccccc2)c2ccccc2)CCNCC1.CCOC(C)=O.Clc1ncnc2[nH]ccc12>>CCOC(=O)C1(CN=C(c2ccccc2)c2ccccc2)CCN(c2ncnc3[nH]ccc23)CC1",
        "output": "540"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NC(C(=O)OCc1ccccc1)C1(O)CCSC1.CO.O.O=C([O-])O.[K+]>>CC(C)(C)OC(=O)NC(C(=O)O)C1(O)CCSC1",
        "output": "186"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.C=CC(=O)Cl.CN(C)c1ccccc1.Cc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1.O=C(O)c1ccc(/C=C/c2ccc(OCCCCCCO)cc2)cc1>>C=CC(=O)OCCCCCCOc1ccc(/C=C/c2ccc(C(=O)O)cc2)cc1",
        "output": "320"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CC(CC(C)C)C(=O)O.CN1CCOCC1.ClCCCl.NCc1ccc(-c2cccs2)s1.On1nnc2ccccc21>>CCOC(=O)CC(CC(C)C)C(=O)NCc1ccc(-c2cccs2)s1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.N.N#CCCn1cnc(N)c1.[H][H].[Ni]>>NCCCn1cnc(N)c1",
        "output": "246"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)c1ccc2oc(-c3cccc(N)c3)nc2c1.O=C(Cl)c1cc(Cl)cc(Cl)c1>>CC(C)(C)c1ccc2oc(-c3cccc(NC(=O)c4cc(Cl)cc(Cl)c4)c3)nc2c1",
        "output": "11"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.Cc1cc(-c2nc3cccnn3c2-c2ccnc(N)c2)ccc1F.O=C(O)c1ccc2ncsc2c1.O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+]>>Cc1cc(-c2nc3cccnn3c2-c2ccnc(NC(=O)c3ccc4ncsc4c3)c2)ccc1F",
        "output": "744"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "B.C1CCOC1.C1CCOC1.CC(C)(C#N)c1ccc([N+](=O)[O-])cc1-c1cccnc1>>CC(C)(CN)c1ccc([N+](=O)[O-])cc1-c1cccnc1",
        "output": "246"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)[Si](Oc1ccc(-n2nc(C(C)(C)C)cc2N)cc1CO)(C(C)C)C(C)C.CCOC(C)=O.O.O=C(Cl)OCC(Cl)(Cl)Cl.[Na+].[OH-]>>CC(C)[Si](Oc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)OCC(Cl)(Cl)Cl)cc1CO)(C(C)C)C(C)C",
        "output": "700"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CN1CCC(N)C1=O.O=C(O)c1ccc(-n2cc(-c3n[nH]c4ccccc34)nn2)cc1>>CN1CCC(NC(=O)c2ccc(-n3cc(-c4n[nH]c5ccccc45)nn3)cc2)C1=O",
        "output": "718"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCCC(C1CCCCC1)N1C(=O)c2ccccc2C1=O.CO.NN>>CC(C)(C)OC(=O)NCCC(N)C1CCCCC1",
        "output": "242"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.ClCCl.NC1CCOCC1.O=Cc1ccc(C(=O)O)cc1.On1nnc2ccccc21>>O=Cc1ccc(C(=O)NC2CCOCC2)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.[H][H].[Pd].c1ccc(CN2CCOCCOCCOCC2)cc1>>C1COCCOCCOCCN1",
        "output": "84"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CN1CCNCC1.O=C(NCC1CCCCC1)c1c(Cl)ccc2nc(Cl)ccc12>>CCOC(=O)CN1CCN(c2ccc3c(C(=O)NCC4CCCCC4)c(Cl)ccc3n2)CC1",
        "output": "220"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.COc1ccc2nc(-c3ccc(C)c(N)c3)cn2n1.Fc1ccc(CBr)cc1.O=C([O-])[O-].[K+].[K+]>>COc1ccc2nc(-c3ccc(C)c(NCc4ccc(F)cc4)c3)cn2n1",
        "output": "272"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(N)cc2)CC1.CC(C)(C)[O-].CN(c1nc(Cl)ncc1Br)C1CCCC1.Cc1ccccc1.[Na+]>>CN(c1nc(Nc2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)cc2)ncc1Br)C1CCCC1",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)CN(CCNC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)Cn1cnc2c(NC(=O)OCc3ccccc3)nc(N)nc21.CO.ClCCl.ClCCl.O=C(O)C(F)(F)F>>Nc1nc(NC(=O)OCc2ccccc2)c2ncn(CC(=O)N(CCNC(=O)OCC3c4ccccc4-c4ccccc43)CC(=O)O)c2n1",
        "output": "278"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccc(Oc2cccc(OCC3CCN(C(=O)OC(C)(C)C)C3)c2)cc1.Cl>>Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccc(Oc2cccc(OCC3CCNC3)c2)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)C(=O)Cl.CCCCCCN1CCc2c1cc(C)c(N)c2C.CCN(CC)CC.ClC(Cl)Cl.O>>CCCCCCN1CCc2c1cc(C)c(NC(=O)C(C)(C)C)c2C",
        "output": "9"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc2ncc(=O)n(CC3OCCO3)c2n1.O=C(O)C(F)(F)F>>COc1ccc2ncc(=O)n(CC=O)c2n1",
        "output": "740"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1C(=O)N(C(=O)[C@H](C)N)c2cccc(N)c2-c2ccccc21.O=C(O)c1cc2ccccc2[nH]1>>CC1C(=O)N(C(=O)[C@H](C)NC(=O)c2cc3ccccc3[nH]2)c2cccc(N)c2-c2ccccc21",
        "output": "738"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCCC(C(=O)O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.CN(C)C=O.Cl.ClCCl.NC1(c2ccccc2)CCC(=O)CC1.O=C(Cl)C(=O)Cl.c1ccncc1>>C=CCCC(C(=O)NC1(c2ccccc2)CCC(=O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "599"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CCO.Cc1[nH]c(C=O)c(CCC(=O)O)c1S(C)(=O)=O.O=C1Cc2cc(Br)ccc2N1>>Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(Br)cc32)c(CCC(=O)O)c1S(C)(=O)=O",
        "output": "911"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(O)(CC1=CCOc2ccccc21)C(F)(F)F.CCOCC.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[Li+].[NH4+]>>O=CC(O)(CC1=CCOc2ccccc21)C(F)(F)F",
        "output": "260"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cn(C2CC2)c2c(Cl)c(F)c(F)c([N+](=O)[O-])c2c1=O.ClCCl.[H][H].[Ni]>>CCOC(=O)c1cn(C2CC2)c2c(Cl)c(F)c(F)c(N)c2c1=O",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(S(=O)(=O)OCC2Cc3cc(F)cc(-c4c(Cl)cccc4Cl)c3O2)cc1.NC1CC1>>Fc1cc2c(c(-c3c(Cl)cccc3Cl)c1)OC(CNC1CC1)C2",
        "output": "853"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC1(F)CN(C2CCCC2)c2nc(Nc3ccc(C(=O)O)cc3OC)ncc2N(C)C1=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCC(N)CC1.F[P-](F)(F)(F)(F)F>>CCC1(F)CN(C2CCCC2)c2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)ncc2N(C)C1=O",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CS(=O)(=O)CC(=O)O.Cl.Nc1cccc(C#Cc2cncnc2Nc2ccc(OCc3cccc(F)c3)c(Cl)c2)c1.O.On1nnc2ccccc21>>CS(=O)(=O)CC(=O)Nc1cccc(C#Cc2cncnc2Nc2ccc(OCc3cccc(F)c3)c(Cl)c2)c1",
        "output": "365"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccccc1.Cl.Cl.O.O=C([O-])[O-].OB(O)c1ccccc1C(F)(F)F.OCc1ccnc(Br)c1.[Fe+2].[K+].[K+].[Pd+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>OCc1ccnc(-c2ccccc2C(F)(F)F)c1",
        "output": "869"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN.c1ccc(CN2CCC3(CO3)C2)cc1>>CCNCC1(O)CCN(Cc2ccccc2)C1",
        "output": "16"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)Cc1ccc(Cc2n[nH]c3c2c(=O)n(-c2ccccc2)c2ncccc32)cc1.CS(C)=O.O.O=S(=O)(O)O>>O=C(O)Cc1ccc(Cc2n[nH]c3c2c(=O)n(-c2ccccc2)c2ncccc32)cc1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.CCc1cc2c(OC)cccc2n1Cc1ccccc1.ClCCl>>CCc1cc2c(O)cccc2n1Cc1ccccc1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=C1CCC1.O=C1c2ccc(O)cc2CCN1[C@@H]1CCNC1>>O=C1c2ccc(O)cc2CCN1[C@@H]1CCN(C2CCC2)C1",
        "output": "187"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CNC(=O)c1ccccc1Nc1nc(Cl)ncc1Cl.Nc1ccc2c(c1)NC(=O)CCC2>>CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)NC(=O)CCC3)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOc1ccc(Cl)cc1-c1cc(Cl)nc(N)n1.N#Cc1ccc(N)cc1>>CCOc1ccc(Cl)cc1-c1cc(Nc2ccc(C#N)cc2)nc(N)n1",
        "output": "161"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCCN(CCCC)c1cccc(-c2ccc(C(=O)OC)cc2C(=O)N2CCc3ccccc3C2)n1.CO.Cl.[Na+].[OH-]>>CCCCN(CCCC)c1cccc(-c2ccc(C(=O)O)cc2C(=O)N2CCc3ccccc3C2)n1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cc1cc(C(=O)O)ccc1N1CCOCC1=O.F[B-](F)(F)F.N[C@@H](CCc1nnn[nH]1)c1nc2cc(Cl)ccc2[nH]1>>Cc1cc(C(=O)N[C@@H](CCc2nnn[nH]2)c2nc3cc(Cl)ccc3[nH]2)ccc1N1CCOCC1=O",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc(N)ccc1Br.ClCCl.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+]>>COc1cc(NC(=O)[C@@H](CC(C)C)NC(=O)OC(C)(C)C)ccc1Br",
        "output": "365"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.COC(=O)[C@@H](C)N(C)C(=O)C(CC(=O)OC(C)(C)C)c1ccc(O)cc1.FC(F)(F)c1cc(CBr)cc(C(F)(F)F)c1.O=C([O-])[O-].[K+].[K+]>>COC(=O)[C@@H](C)N(C)C(=O)C(CC(=O)OC(C)(C)C)c1ccc(OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.C1COCCN1.CCCP(=O)=O.CCN(C(C)C)C(C)C.CN(C)c1nc2cc(NC(=O)c3c(C(=O)O)cnn3C)ccn2n1>>CN(C)c1nc2cc(NC(=O)c3c(C(=O)N4CCOCC4)cnn3C)ccn2n1",
        "output": "733"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN.O=[N+]([O-])c1cc(F)ccc1F>>CNc1ccc(F)cc1[N+](=O)[O-]",
        "output": "572"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.CN1CCOCC1.COc1nc(OC)nc([N+]2(C)CCOCC2)n1.C[C@H](N)C(=O)OCc1ccccc1.Cl.ClCCl.O=C(O)CN1CCOCC1.[Cl-]>>C[C@H](NC(=O)CN1CCOCC1)C(=O)OCc1ccccc1",
        "output": "132"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.NC(=O)c1cnc(Cl)c(Cl)c1>>CC(C)(C)OC(=O)N1CCN(c2ncc(C(N)=O)cc2Cl)CC1",
        "output": "220"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc(C(=O)O)cc1B1OC(C)(C)C(C)(C)O1.F[P-](F)(F)(F)(F)F.NCC1CC1>>Cc1ccc(C(=O)NCC2CC2)cc1B1OC(C)(C)C(C)(C)O1",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.O=[N+]([O-])c1cc(-c2ccccc2)cc([N+](=O)[O-])c1Cl.[Ni]>>Nc1cc(-c2ccccc2)cc(N)c1Cl",
        "output": "204"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CCCCCC#CCBr.CCOC(C)=O.O=C([O-])[O-].O=c1ccc2ccc(O)cc2o1.[K+].[K+]>>CCCCCC#CCOc1ccc2ccc(=O)oc2c1",
        "output": "154"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CN(C)C=O.CN1CCN(c2ccc(N=C=O)cc2)CC1.Nc1ccc(-c2cnco2)cc1.O>>CN1CCN(c2ccc(NC(=O)Nc3ccc(-c4cnco4)cc3)cc2)CC1",
        "output": "473"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCC[C@@H](C)Oc1ccc(-c2ccc(C(=O)OC)cc2)cc1[N+](=O)[O-].CO.[Pd]>>CCCCCC[C@@H](C)Oc1ccc(-c2ccc(C(=O)OC)cc2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(C2CCCNC2)cc1.Cl.O=C(O)c1ccnc(F)c1.O=C(c1ccnc(F)c1)N1CCCC(c2ccc(Cl)cc2)C1>>Cc1ccc(C2CCCN(C(=O)c3ccnc(F)c3)C2)cc1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.ClCCl.Nc1cccc(-n2ccnc2)c1.O=C(Cl)C(=O)Cl.O=C(O)C1=Cc2cc(Cl)ccc2OCC1.c1ccncc1>>O=C(Nc1cccc(-n2ccnc2)c1)C1=Cc2cc(Cl)ccc2OCC1",
        "output": "170"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(CC)C(=O)Cl.Nc1cc(N2CCN(C(c3ccccc3)c3ccccc3)CC2)c(F)cc1[N+](=O)[O-]>>CCC(CC)C(=O)Nc1cc(N2CCN(C(c3ccccc3)c3ccccc3)CC2)c(F)cc1[N+](=O)[O-]",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cc1nc(O[C@@H]2CC[C@@H](C(C)C)CC2)c(Br)cc1[N+](=O)[O-].O.[Cl-].[Fe].[NH4+]>>Cc1nc(O[C@@H]2CC[C@@H](C(C)C)CC2)c(Br)cc1N",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)(C)c1ccc(N)cc1.CCCCCC.Clc1ncnc2c1CCN(Cc1ccccc1)C2>>CC(C)(C)c1ccc(Nc2ncnc3c2CCN(Cc2ccccc2)C3)cc1",
        "output": "352"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)C[C@H](Cc1ccc(OCCCNC2=NCCCN2)cc1)c1ccccc1.[Na+].[OH-]>>O=C(O)C[C@H](Cc1ccc(OCCCNC2=NCCCN2)cc1)c1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[O-].CC(C)Oc1cccc(OC(C)C)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.CC(O)(c1ccc(Br)cc1)C(F)(F)F.C[C@H]1COCCN1C[C@H]1CN(S(=O)(=O)c2nccs2)CCN1.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>C[C@H]1COCCN1C[C@H]1CN(S(=O)(=O)c2nccs2)CCN1c1ccc(C(C)(O)C(F)(F)F)cc1",
        "output": "294"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(c1ccc(NC(=O)Nc2ccccc2)cc1)S(=O)(=O)c1ccc(C2=CCN(C(=O)OC(C)(C)C)CC2)s1.ClCCl.O=C(O)C(F)(F)F>>CN(c1ccc(NC(=O)Nc2ccccc2)cc1)S(=O)(=O)c1ccc(C2=CCNCC2)s1",
        "output": "800"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Nc1ccc(O)c(C(=O)O)c1.O>>CC(C)(C)OC(=O)Nc1ccc(O)c(C(=O)O)c1",
        "output": "735"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N(C)C.Cc1cccc(C(=O)Nc2cccc(Oc3ccc4nc(N)cn4c3)c2)n1.O=C(Cl)C1CC1.O=C([O-])O.[Na+]>>Cc1cccc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4c3)c2)n1",
        "output": "399"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cl.Cl[Sn]Cl.O=[N+]([O-])c1ccccc1S(=O)(=O)Nc1cccc2c(C(F)(F)F)ccnc12>>Nc1ccccc1S(=O)(=O)Nc1cccc2c(C(F)(F)F)ccnc12",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCOc1ccc(-c2ccccc2)cc1.CC(C)(C)[O-].CN(C)C=O.O.O=Cc1ccc(O)cc1F.[K+]>>O=Cc1ccc(OCCCOc2ccc(-c3ccccc3)cc2)cc1F",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CI.CN(C)C=O.OC(c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl)C1CC1.[Cl-].[H-].[NH4+].[Na+]>>COC(c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl)C1CC1",
        "output": "140"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)c1sc(C#CC(C)(C)C)cc1N(C(=O)[C@@H]1CC[C@@H](C)CC1)C(C)CC(=O)N1CCCC1.Cl.O.O.[Li+].[OH-]>>CC(CC(=O)N1CCCC1)N(C(=O)[C@@H]1CC[C@@H](C)CC1)c1cc(C#CC(C)(C)C)sc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1C(=O)C(C)(C)C(C)(C)c2ccccc21.O=C(Cl)CCl>>CN1C(=O)C(C)(C)C(C)(C)c2cc(C(=O)CCl)ccc21",
        "output": "31"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.O.O=c1[nH]c2cc(Cl)ccc2n1CCCO>>O=c1[nH]c2cc(Cl)ccc2n1CCCBr",
        "output": "224"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.O=[N+]([O-])c1cccnc1Nc1ccccc1.[Pd]>>Nc1cccnc1Nc1ccccc1",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCS(=O)(=O)Cl.COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCN>>CCS(=O)(=O)NCCOc1nc(C)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC",
        "output": "493"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)c2ccc3c(c2)OCCO3)C[C@@H]1c1nc2ccccc2n1CCO.CCOC(C)=O.CN(C)c1ccncc1.CS(=O)(=O)Cl.O.c1ccncc1>>CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)c2ccc3c(c2)OCCO3)C[C@@H]1c1nc2ccccc2n1CCOS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCC.Fc1c(Cl)nc(C2CC2)nc1Cl.NC1CC1>>Fc1c(Cl)nc(C2CC2)nc1NC1CC1",
        "output": "166"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cn1cc(-c2ccnc(N3CCc4c(sc5c4CC(C)(C)C5)C3=O)c2C=O)cc(Nc2ccncn2)c1=O.[BH4-].[Na+]>>Cn1cc(-c2ccnc(N3CCc4c(sc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2ccncn2)c1=O",
        "output": "476"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1ccc(Br)c(C)c1.NN.O>>Cc1cc(C(=O)NN)ccc1Br",
        "output": "421"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.O=C(O)Cc1ccc(C(F)(F)F)cc1.O=S(=O)(O)O>>CCOC(=O)Cc1ccc(C(F)(F)F)cc1",
        "output": "17"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.CC1CCCC(=O)C1.Nn1c(=O)c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2sccc21>>CC1CCCC(=Nn2c(=O)c(C3=NS(=O)(=O)c4ccccc4N3)c(O)c3sccc32)C1",
        "output": "285"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCC.CCOC(=O)CCNc1ccc(C(C)(C)C)cc1.CCOC(C)=O.CN(C)C=O.N#CCC(=O)O>>CCOC(=O)CCN(C(=O)CC#N)c1ccc(C(C)(C)C)cc1",
        "output": "315"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CCN(CC)CC.COC(=O)Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>COC(=O)Cc1ccc(S(=O)(=O)N2CCOCC2)cc1",
        "output": "99"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)CC(c1csc(N2CCC(O)CC2)n1)N1CCCN(c2c(OC)ccc3cccnc23)CC1.[Na+].[OH-]>>COc1ccc2cccnc2c1N1CCCN(C(CC(=O)O)c2csc(N3CCC(O)CC3)n2)CC1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)NS(=O)(=O)c1ccc(-c2ncc(CCCO)c(Nc3cc(C4CC4)[nH]n3)n2)s1.O=C(O)C(F)(F)F>>NS(=O)(=O)c1ccc(-c2ncc(CCCO)c(Nc3cc(C4CC4)[nH]n3)n2)s1",
        "output": "680"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COC(=O)COc1ccc(OC)cc1-c1ccco1.NN>>COc1ccc(OCC(=O)NN)c(-c2ccco2)c1",
        "output": "130"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.Cn1cc(-c2cc3c(cc2C(F)F)N(c2nn(-c4ccccc4)c4c2CN(C(=O)OC(C)(C)C)CC4)CCC3)cn1.O=C(O)C(F)(F)F>>Cn1cc(-c2cc3c(cc2C(F)F)N(c2nn(-c4ccccc4)c4c2CNCC4)CCC3)cn1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCNC(=O)N(Cc1ccc(Cl)c(Cl)c1)NC(=O)CCCc1ccc(OC(C)(C)C(=O)OCC)cc1.CO.[Na+].[OH-]>>CCCNC(=O)N(Cc1ccc(Cl)c(Cl)c1)NC(=O)CCCc1ccc(OC(C)(C)C(=O)O)cc1",
        "output": "192"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CNC.N#Cc1cn(Cc2ccc(C(F)(F)F)cc2)c2cc(F)c(F)cc2c1=O>>CN(C)c1cc2c(cc1F)c(=O)c(C#N)cn2Cc1ccc(C(F)(F)F)cc1",
        "output": "676"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc(F)c([N+](=O)[O-])cc1F.Clc1ccccc1.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>O=[N+]([O-])c1cc(F)c(CBr)cc1F",
        "output": "29"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O.O=C(OCc1ccccc1)c1cccc(F)c1OCc1ccccc1.[Na+].[OH-]>>O=C(O)c1cccc(F)c1OCc1ccccc1",
        "output": "290"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCN(C)C(=O)OC(C)(C)C.O.[Na+].[OH-]>>CN(CCC(=O)O)C(=O)OC(C)(C)C",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc2ccccc2c1.CN(C)C=O.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3.O.O=C(O)[C@@H]1CCCN1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>Cc1ccc2c(c1)c1c(n2-c2ccc3ccccc3c2)CCN(C)C1",
        "output": "349"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(-c2ccccc2C(=O)O)cc1C.Cc1nc2sccn2c1C(=O)NC[C@H]1NC[C@@H]2C[C@H]12>>Cc1ccc(-c2ccccc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2c(C)nc3sccn23)cc1C",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1c(Cl)c(C)c(C(C)=O)c(OCCBr)c1OCCC(C)c1ccc(F)cc1.ClCCl.c1c[nH]cn1>>COc1c(Cl)c(C)c(C(C)=O)c(OCCn2ccnc2)c1OCCC(C)c1ccc(F)cc1",
        "output": "495"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)N(C(=O)COCCCCO)C1CCN(Cc2ccccc2)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)N(CCOCCCCO)C1CCN(Cc2ccccc2)CC1",
        "output": "112"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCCCBr.CN([C@@H]1CC[C@@H](O)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1>>CN([C@@H]1CC[C@@H](OCCCBr)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1",
        "output": "95"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CC(=O)Cl.CCN(C(C)C)C(C)C.CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)[C@@H](CO)C3)cc2)nc1Oc1cccc(N)c1.ClC(Cl)Cl.ClCCl.O>>C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)[C@@H](CO)C4)cc3)c(C(N)=O)nc2CC)c1",
        "output": "10"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOC(=O)/C=C/c1cnc(N[C@@H]2CCNC2)c(Cl)c1.CCOC(C)=O.CN(C)C=O.Cl.Cl.O.O=C(Cl)C1CCCCC1>>CCOC(=O)/C=C/c1cnc(N[C@@H]2CCN(C(=O)C3CCCCC3)C2)c(Cl)c1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN1CCN(C(=O)Cc2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1.CCO.[Ni]>>CCN1CCN(C(=O)Cc2ccc(N)cc2C(F)(F)F)CC1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCOC(=O)c1cc2cc(NC(=O)OCc3ccccc3)ccc2[nH]1.Cl.O.[K+].[OH-]>>O=C(Nc1ccc2[nH]c(C(=O)O)cc2c1)OCc1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCC.CCN(C(C)C)C(C)C.CCOC(C)=O.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)[C@@H](N)C1CCCCC1.Cl.F[P-](F)(F)(F)(F)F.Nc1cc(Cl)c(Cl)cc1C(=O)O>>COC(=O)[C@@H](NC(=O)c1cc(Cl)c(Cl)cc1N)C1CCCCC1",
        "output": "652"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCl.CN(C)C=O.ClCCCCI.O=[N+]([O-])c1ccc2cc[nH]c2c1.[H-].[Na+].c1ccc2[nH]ccc2c1>>O=[N+]([O-])c1ccc2ccn(CCCCCl)c2c1",
        "output": "302"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CNC1.CC(C)(C)OC(=O)Nc1cccc(C(=O)O)c1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O>>CC(C)(C)OC(=O)Nc1cccc(C(=O)N2CCC2)c1",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NCCCn1c(Cc2cc3c(cc2I)OCO3)nc2c(N)nc(F)nc21.ClCCl.O=C(O)C(F)(F)F>>NCCCn1c(Cc2cc3c(cc2I)OCO3)nc2c(N)nc(F)nc21",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.CC(C)(C)[Si](C)(C)OCC[C@H]1C[C@@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CC[C@]1(C)[C@H]1CC[C@@]2(C)[C@@H](CCC23OCCO3)[C@@H]1O.CCOC(C)=O.CN(C)c1ccncc1.O=C([O-])O.[Na+].c1ccncc1>>CC(=O)O[C@@H]1[C@@H]([C@@]2(C)CC[C@H](O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)C[C@@H]2CCO[Si](C)(C)C(C)(C)C)CC[C@@]2(C)[C@H]1CCC21OCCO1",
        "output": "254"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CN(Cc1ccc(OCCc2nc(-c3ccc(C)cc3)oc2C)cc1)S(=O)(=O)N1CCCc2ccccc21.O.[Li+].[OH-]>>Cc1ccc(-c2nc(CCOc3ccc(CN(CC(=O)O)S(=O)(=O)N4CCCc5ccccc54)cc3)c(C)o2)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1cc(C(OCOC)(C(F)(F)F)C(F)(F)F)ccc1Oc1cccc(C=O)c1.CO.O.[BH4-].[Na+]>>CCCc1cc(C(OCOC)(C(F)(F)F)C(F)(F)F)ccc1Oc1cccc(CO)c1",
        "output": "356"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC=O.CO.ClCCl.NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(C3CCNCC3)cc2)ncc1C(F)(F)F.[Na+]>>CCN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cc2)CC1",
        "output": "484"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCC2=NCCCN2CC1.CC#N.CC1CNCC1CN.O=C(O)c1cn(C2CC2)c2c(Cl)c(F)c(F)cc2c1=O>>CC1CN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)CC1CN",
        "output": "676"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.CC(C)(C)[O-].COCOc1ccc(Br)cc1Cl.Cc1ccccc1.[Na+]>>COCOc1ccc(N2CCOCC2)cc1Cl",
        "output": "294"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CI.CS(C)=O.O=Cc1c[nH]c2ccccc12.[K+].[OH-]>>Cn1cc(C=O)c2ccccc21",
        "output": "191"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)N=C=O.COC(=O)c1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2/C=C/c2ccc(-c3ccc(N)c(OC)c3)cc2)cc1>>COC(=O)c1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2/C=C/c2ccc(-c3ccc(NC(=O)NC(C)C)c(OC)c3)cc2)cc1",
        "output": "176"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)c1ccc(NC(=O)Cn2c3c(c(-c4cc(Cl)ccc4Cl)cc2=O)C(=O)CC3)cc1.O=C(O)C(F)(F)F>>O=C(Cn1c2c(c(-c3cc(Cl)ccc3Cl)cc1=O)C(=O)CC2)Nc1ccc(C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(F)c2nc(N3C4CCC3CC(OCc3c(-c5ccccc5OC(F)(F)F)noc3C3CC3)C4)sc2c1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[K+].[OH-]>>O=C(O)c1cc(F)c2nc(N3C4CCC3CC(OCc3c(-c5ccccc5OC(F)(F)F)noc3C3CC3)C4)sc2c1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(c1cc(F)ccc1O)c1cc(F)ccc1O.COc1ccc(F)cc1C(C)(C)c1cc(Cl)ccc1O>>CC(C)(c1cc(F)ccc1O)c1cc(Cl)ccc1O",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCS(N)(=O)=O.COc1ccccc1Nc1c(C(=O)N2CCC(c3ccccc3)CC2)cnc2c(C(=O)O)cnn12>>CCS(=O)(=O)NC(=O)c1cnn2c(Nc3ccccc3OC)c(C(=O)N3CCC(c4ccccc4)CC3)cnc12",
        "output": "991"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCCCCBr.Oc1ccc2c(ccn2-c2ccc(Br)cc2)c1>>BrCCCCOc1ccc2c(ccn2-c2ccc(Br)cc2)c1",
        "output": "75"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N(C)C.COc1cc(Nc2nc3ccccc3nc2NS(=O)(=O)c2cccc([N+](=O)[O-])c2)cc(OC)c1.Cl[Sn](Cl)(Cl)Cl.O.O>>COc1cc(Nc2nc3ccccc3nc2NS(=O)(=O)c2cccc(N)c2)cc(OC)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc(N)ccc1F.O=C([O-])Cc1nc(N2CCOCC2)cc(=O)[nH]1.[Na+]>>Cc1cc(NC(=O)Cc2nc(N3CCOCC3)cc(=O)[nH]2)ccc1F",
        "output": "891"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(=O)Nc1cccc(C#N)c1.Fc1ccc(CBr)cc1>>CCC(=O)N(Cc1ccc(F)cc1)c1cccc(C#N)c1",
        "output": "688"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCC1(N(C)C)CCC2(CCNC2)CC1.O=C(O)CC1CC1>>CCCCC1(N(C)C)CCC2(CCN(C(=O)CC3CC3)C2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.CCN(CC)CC.CCc1cnc(Cl)nc1.Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCNCC2)c1F.Cl>>CCc1cnc(N2CCC(Oc3ncnc(Oc4ccc(S(C)(=O)=O)nc4C)c3F)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)C=O.C[C@H]1CCC[C@@H](C)N1CCN.O.O=C(O)CN1CCC(O)C1=O>>C[C@H]1CCC[C@@H](C)N1CCNC(=O)CN1CCC(O)C1=O",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.CN1C(=O)CCCc2cc(N)ccc21.NC(=O)c1cc(N2CCOCC2)ccc1Nc1nc(Cl)ncc1Cl>>CN1C(=O)CCCc2cc(Nc3ncc(Cl)c(Nc4ccc(N5CCOCC5)cc4C(N)=O)n3)ccc21",
        "output": "808"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.CCOC(CCNC(=O)C(C)(COC)COC)OCC.Cc1ccc(S(=O)(=O)O)cc1.O>>COCC(C)(COC)C(=O)NCCC=O",
        "output": "409"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CC[C@H](c2ccc(F)cc2)[C@@H](O)C1.CI.[H-].[Na+]>>CO[C@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1c1ccc(F)cc1",
        "output": "140"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.ClCCl.Nc1nnc(-c2ccc(Br)cc2F)s1.[K+]>>CC1(C)OB(c2ccc(-c3nnc(N)s3)c(F)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cc1c(C#C[Si](C)(C)C)cnc(N)c1C#N.O=C([O-])[O-].[K+].[K+]>>C#Cc1cnc(N)c(C#N)c1C",
        "output": "337"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)/N=N/C(=O)OCC.Cc1ccccc1O.O=C(c1csc(CO)c1)N1CCCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1ccccc1OCc1cc(C(=O)N2CCCCC2)cs1",
        "output": "550"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Cn1ccnc1[C@H](O)CCCNC(=O)OC(C)(C)C.N#Cc1cc(F)c(Cl)cc1F.O.[H-].[Na+]>>Cn1ccnc1[C@@H](CCCNC(=O)OC(C)(C)C)Oc1cc(Cl)c(F)cc1C#N",
        "output": "485"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.Cc1noc(NC(=O)OCC(Cl)(Cl)Cl)c1C.O.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>Cc1noc(NC(=O)N2CCN(c3nc(-c4ccccc4)ns3)CC2)c1C",
        "output": "980"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1C2COCC1C(F)c1oncc12.ClCCl.O=C(O)C(F)(F)F>>FC1c2oncc2C2COCC1N2",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.Cc1cc(I)ccc1N.ClCCOCCCl.[Br-].[NH4+].[Na+].[OH-]>>Cc1cc(I)ccc1N1CCOCC1",
        "output": "640"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CN)c1.O=C(O)c1cnc2sccn12>>Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2cnc3sccn23)c1",
        "output": "697"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.CC(C)(C)OC(=O)N1CCNCC1.O=C(O)COc1cccc([N+](=O)[O-])c1.O=C([O-])[O-].O=S(Cl)Cl.[Ar].[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCN(C(=O)COc2cccc([N+](=O)[O-])c2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cccc(Oc2ccccc2)c1C.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>CCOC(=O)c1cccc(Oc2ccccc2)c1CBr",
        "output": "545"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)C(C(=O)O)C1C(=O)O.Cc1ccccc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC1(C)C2C(=O)OC(=O)C21",
        "output": "436"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(C(=O)O)cc1.O.O=S(=O)(O)Cl>>COc1ccc(C(=O)O)cc1S(=O)(=O)Cl",
        "output": "357"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=CCCC(C)CC=O.Cl.NO.O.O=C([O-])[O-].[Na+].[Na+]>>CC(C)=CCCC(C)CC=NO",
        "output": "118"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Cc1nn(-c2ccc(O)cc2)c2c1CCc1ccccc1-2.ClCCCN1CCCC1.O=C([O-])O.[H-].[I-].[Na+].[Na+].[Na+]>>Cc1nn(-c2ccc(OCCCN3CCCC3)cc2)c2c1CCc1ccccc1-2",
        "output": "74"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O=C(O)c1cc2ccc(Cl)cc2[nH]1.O=S(=O)(O)O>>CCOC(=O)c1cc2ccc(Cl)cc2[nH]1",
        "output": "331"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O.CC(C)(C)OC(=O)N1CCC(NCc2ccc(-c3ccc(S(C)(=O)=O)cc3)nc2)CC1.O.O=C1CCC1.[BH3-]C#N.[Na+]>>CC(C)(C)OC(=O)N1CCC(N(Cc2ccc(-c3ccc(S(C)(=O)=O)cc3)nc2)C2CCC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)N1c2ccc(C#N)cc2[C@H](N)[C@@H](C)[C@@H]1C1CC1.CC(C)(C)[O-].CC(C)(C)[Si](C)(C)OCc1cccc(Br)c1.CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CC(=O)N1c2ccc(C#N)cc2[C@H](Nc2cccc(CO[Si](C)(C)C(C)(C)C)c2)[C@@H](C)[C@@H]1C1CC1",
        "output": "932"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)CCc1c[nH]c2ccc([N+](=O)[O-])c(C)c12.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1c([N+](=O)[O-])ccc2[nH]cc(CCCO)c12",
        "output": "225"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O=C(O)c1ccc(Cl)c(F)c1.O=S(Cl)Cl>>COC(=O)c1ccc(Cl)c(F)c1",
        "output": "33"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1.ClCCCl.ClCCl.NCc1ccccn1.On1nnc2ccccc21>>Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)NCc2ccccn2)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(C(=O)OC)CC2.CCOC(C)=O.CO.[Li+].[OH-]>>CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1nc(N)ccc1-n1cnc(C)c1.Cc1cnc(C2CN(C)Cc3ccc(Cl)nc3O2)s1>>COc1nc(Nc2ccc3c(n2)OC(c2ncc(C)s2)CN(C)C3)ccc1-n1cnc(C)c1",
        "output": "606"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CC1COCCN1.C[Si](C)(C)[N-][Si](C)(C)C.Nc1cc(Br)cnc1N1CCOCC1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Li+].[Pd].[Pd]>>CC1COCCN1c1cnc(N2CCOCC2)c(N)c1",
        "output": "597"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1[nH]c2c(c1C)N(C)NCC2.O=C(O)c1cc2ncc(Cl)cn2n1>>Cc1[nH]c2c(c1C)N(C)N(C(=O)c1cc3ncc(Cl)cn3n1)CC2",
        "output": "995"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.CCOC(=O)c1c(O)c2sc(C)nc2n(C)c1=O.Cc1nc2c(s1)c(O)c(C(=O)NCC(=O)OC(C)(C)C)c(=O)n2C>>Cc1nc2c(s1)c(O)c(C(=O)NCC(=O)O)c(=O)n2C",
        "output": "278"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC#N.CCC(C(=O)N(CC(=O)OC)C1CCN(Cc2cccc(Oc3ccccc3OC)c2)CC1)c1ccccc1.O.O.[Li+].[OH-]>>CCC(C(=O)N(CC(=O)O)C1CCN(Cc2cccc(Oc3ccccc3OC)c2)CC1)c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.CC(C)(C)[O-].Cc1cc(C)c(Br)c(C)c1N.Cc1ccccc1.Cl.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd]>>Cc1cc(C)c(N2CCOCC2)c(C)c1N",
        "output": "294"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cl.O=C(O)c1ccc2cc(Br)ccc2n1>>COC(=O)c1ccc2cc(Br)ccc2n1",
        "output": "331"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCCS(=O)(=O)C(C)C(=O)OCC.CCCCCCCCS(=O)(=O)C(Cc1ccc(OCCN2CCCCC2)cc1)C(=O)OCC.CCO.[Na+].[OH-]>>CCCCCCCCS(=O)(=O)C(Cc1ccc(OCCN2CCCCC2)cc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCCCCCCCCCCCCCOc1ccc(C(=O)OC)cc1OCCCCCCCCCCCCCC.CO.[Na+].[OH-]>>CCCCCCCCCCCCCCOc1ccc(C(=O)O)cc1OCCCCCCCCCCCCCC",
        "output": "222"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1nc(C2CCCCC2)nc(O)c1C.O=P(Cl)(Cl)Cl>>Cc1nc(C2CCCCC2)nc(Cl)c1C",
        "output": "168"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.COc1cc(Nc2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)cc2)c(NC(C)=O)cn1.Cl.O.O=C([O-])O.O=CO.[Na+]>>COc1cc(Nc2ccc(N3CCNCC3)cc2)c(NC(C)=O)cn1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N[C@H](CO)CC1CCC(O[Si](C)(C)C(C)(C)C)CC1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O>>CC(C)(C)OC(=O)N[C@H](COS(C)(=O)=O)CC1CCC(O[Si](C)(C)C(C)(C)C)CC1",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CC(=O)[O-].COCCOC.C[C@@H]1CNC(=O)c2cc3cccc(Br)c3n21.O.O=C([O-])[O-].OB(O)c1ccccc1.[Na+].[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C[C@@H]1CNC(=O)c2cc3cccc(-c4ccccc4)c3n21",
        "output": "833"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc2ccc(C(F)(F)F)cc2n1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>FC(F)(F)c1ccc2ccc(CBr)nc2c1",
        "output": "590"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.C=C(C)n1c(=O)n(CCCCl)c2ccccc21.CC(=O)CC(C)C.Cc1cccc(C(=O)CC2CCNCC2)c1.O.O=C([O-])[O-].[Na+].[Na+]>>C=C(C)n1c(=O)n(CCCN2CCC(CC(=O)c3cccc(C)c3)CC2)c2ccccc21",
        "output": "138"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C=CC[C@@]1(C)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N([C@@H](CC)CC(C)=O)C1=O.C[Mg]Br.Cc1ccccc1>>C=CC[C@@]1(C)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N([C@@H](CC)CC(C)(C)O)C1=O",
        "output": "514"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CO.ClCCl.Cl[Pd]Cl.N#Cc1ccc(Br)cc1.O.O=C([O-])[O-].OB(O)c1ccc(F)nc1.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>N#Cc1ccc(-c2ccc(F)nc2)cc1",
        "output": "899"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.ClCCl.Cn1c(=O)ccc2ccc(OCCCCl)cc21.O.[I-].[Na+]>>Cn1c(=O)ccc2ccc(OCCCI)cc21",
        "output": "97"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)CC(c1cccc(OCc2ccc(-c3cc(OC)ccc3F)c(CC(C)(C)C)n2)c1)C1CC1.Cl.[Na+].[OH-]>>COc1ccc(F)c(-c2ccc(COc3cccc(C(CC(=O)O)C4CC4)c3)nc2CC(C)(C)C)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.COc1ccc([N+](=O)[O-])cc1-c1cccc(CN)c1.ClCCl.[BH4-].[Na+]>>COc1ccc([N+](=O)[O-])cc1-c1cccc(CNC(C)C)c1",
        "output": "589"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(O)ccn1.O=C([O-])[O-].O=S(=O)(O)O.O=[N+]([O-])O.[Na+].[Na+]>>Cc1nccc(O)c1[N+](=O)[O-]",
        "output": "328"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.CCOP(=O)(OCC)c1cc(O[Si](C)(C)C(C)(C)C)ccc1C.[F-]>>CCOP(=O)(OCC)c1cc(O)ccc1C",
        "output": "754"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCN1CC(C)(C)OC(=O)C1CC(=O)O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCc1ccccc1-c1ccccc1>>CCN1CC(C)(C)OC(=O)C1CC(=O)NCc1ccccc1-c1ccccc1",
        "output": "599"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCC.CCOC(C)=O.COc1ccc(-c2ccc(Br)s2)cc1.COc1cccc(B(O)O)c1>>COc1ccc(-c2ccc(-c3cccc(OC)c3)s2)cc1",
        "output": "864"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)c1cc(Cl)ccc1Nc1ccc2c(ccn2-c2ccc(Cl)cc2)c1.Cl.O.[Na+].[OH-]>>O=C(O)c1cc(Cl)ccc1Nc1ccc2c(ccn2-c2ccc(Cl)cc2)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CC(C)(C)OC(=O)c1cc(Cl)nc(C(F)(F)F)c1.CCN(C(C)C)C(C)C.CCOC(C)=O.CS(C)=O>>CC(C)(C)OC(=O)c1cc(NC2CCN(C(=O)OC(C)(C)C)CC2)nc(C(F)(F)F)c1",
        "output": "70"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CCO.O.O=[N+]([O-])c1cn(-c2cccnc2)nc1Cl.[Fe].[K+].[OH-]>>Nc1cn(-c2cccnc2)nc1Cl",
        "output": "628"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.ClCCl.N#CC(c1ccc2c(c1)CCNCC2)c1ccc(Br)cn1.O=C1CCC1.[Na+]>>N#CC(c1ccc2c(c1)CCN(C1CCC1)CC2)c1ccc(Br)cn1",
        "output": "187"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)/C=C/C=C(c1ccccc1F)c1ccccc1F.CO.[Na+].[OH-]>>O=C(O)/C=C/C=C(c1ccccc1F)c1ccccc1F",
        "output": "122"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C(O)c1ccc(C(F)(F)F)cc1.O=S(Cl)Cl>>O=C(Cl)c1ccc(C(F)(F)F)cc1",
        "output": "3"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)C[C@@H](C(=O)NN1C(=O)CNC1=O)[C@H](CCCC1CCCCC1)C(=O)NOC1CCCCO1.CO.Cc1ccc(S(=O)(=O)O)cc1.O>>CC(C)C[C@@H](C(=O)NN1C(=O)CNC1=O)[C@H](CCCC1CCCCC1)C(=O)NO",
        "output": "915"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COc1ccc(CBr)cc1.Oc1ccc(F)c(Br)c1.[H-].[Na+]>>COc1ccc(COc2ccc(F)c(Br)c2)cc1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C1N(C(c2ccccc2)c2ccccc2)c2cccc(F)c2C1(O)c1cc2c(cc1O)OCCO2.O=C1N(C(c2ccccc2)c2ccccc2)c2ccccc2C1(O)c1c(O)cc2c(c1F)OCCO2>>O=C1C(c2c(O)cc3c(c2F)OCCO3)c2ccccc2N1C(c1ccccc1)c1ccccc1",
        "output": "964"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "OCc1[nH]cnc1-c1ccccc1.[Mn+4].[O-2].[O-2]>>O=Cc1[nH]cnc1-c1ccccc1",
        "output": "287"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCC(C)C)cc1CC2CC.CO.O.O.[Li]O>>CCC1Cc2cc(OCC(C)C)c(OC)cc2-c2cc(=O)c(C(=O)O)cn21",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.Cc1cc(Nc2nn(-c3ccc(C(C)(C)C)cc3)c(=O)c3cc([N+](=O)[O-])ccc23)n(C(C)(C)C)n1.[Pd]>>Cc1cc(Nc2nn(-c3ccc(C(C)(C)C)cc3)c(=O)c3cc(N)ccc23)n(C(C)(C)C)n1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(B2OC(C)(C)C(C)(C)O2)c1.ClCCl.Cl[Pd]Cl.O=C(O)c1ccc(Br)cn1.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2ccc(C(=O)O)nc2)c1",
        "output": "938"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.CCOc1ccc(C(F)(F)F)cc1-c1ncnc2c(C(=O)NC3CCNCC3)c(C)[nH]c12.Cl>>CCOc1ccc(C(F)(F)F)cc1-c1ncnc2c(C(=O)NC3CCN(C(C)=O)CC3)c(C)[nH]c12",
        "output": "125"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccnc(-c2nc(SC)nc3sc(C(N)=O)c(N)c23)c1.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>COc1ccnc(-c2nc(S(C)=O)nc3sc(C(N)=O)c(N)c23)c1",
        "output": "595"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.NCc1ccc(F)c(F)c1.O=C(O)c1cc2ccccc2nc1Cl.O=C([O-])O.[Na+]>>O=C(NCc1ccc(F)c(F)c1)c1cc2ccccc2nc1Cl",
        "output": "790"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(O)c1ccn2c(-c3ccc(F)c(Cl)c3)cnc2c1F.OB(O)c1ccc(F)cc1F>>CC(C)(O)c1ccn2c(-c3ccc(F)c(-c4ccc(F)cc4F)c3)cnc2c1F",
        "output": "892"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)CC1CCn2c1cc1cc(OCc3ccc(OCC4CC4)c(C(F)(F)F)c3)ccc12.COc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)CC1CCn2c1cc1cc(OCc3ccc(OCC4CC4)c(C(F)(F)F)c3)ccc12",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(C)=O.COc1ccc(C2=NNC(=O)CC2COCc2ccccc2)c2cc(C(F)(F)F)nn12.[C].[H][H].[Pd]>>COc1ccc(C2=NNC(=O)CC2CO)c2cc(C(F)(F)F)nn12",
        "output": "178"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccccc1C(C)(C)C.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>CC(C)(C)c1ccccc1CBr",
        "output": "29"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCNC(=O)NN(C)CC(=O)O.CCOC(OCC)[C@H](C)N(Cc1cccc2ccccc12)C(=O)[C@@H](N)CC(=O)OC(C)(C)C>>CCNC(=O)NN(C)CC(=O)N[C@@H](CC(=O)OC(C)(C)C)C(=O)N(Cc1cccc2ccccc12)[C@@H](C)C(OCC)OCC",
        "output": "133"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCCC(CCBr)C1.CC(C)(C)OC(=O)N1CCCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(O)cccc32)C1.CN(C)C=O.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(OCCC4CCCN(C(=O)OC(C)(C)C)C4)cccc32)C1",
        "output": "608"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)CC1OB(O)c2cc(Oc3ccnc(Cl)n3)cc(C)c21.CNC>>CCOC(=O)CC1OB(O)c2cc(Oc3ccnc(N(C)C)n3)cc(C)c21",
        "output": "36"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OC(CNC(=S)c1ccc2[nH]c(=O)oc2c1)CN1CCC(Cc2ccccc2)CC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.[F-]>>O=c1[nH]c2ccc(C(=S)NCC(O)CN3CCC(Cc4ccccc4)CC3)cc2o1",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1ccc(Cl)nc1.CN(C)C=O.O.O=C([O-])[O-].Oc1ccc(OC(F)(F)F)cc1.[K+].[K+]>>CCOC(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)nc1",
        "output": "516"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)n1ncc(-c2nc(C(Cc3ccccc3)C(=O)O)cs2)c1-c1ccc(F)cc1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCC1CCOCC1.O>>CC(C)(C)n1ncc(-c2nc(C(Cc3ccccc3)C(=O)NCC3CCOCC3)cs2)c1-c1ccc(F)cc1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.CN(C)c1ccc(B(O)O)cc1.ClCCl.Nc1nc(N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)ncc1Br.O.O=C(O)C(F)(F)F.O=C([O-])[O-].[K+].[K+]>>CN(C)c1ccc(-c2cnc(N3CCC(C(=O)NCc4ccc(Cl)cc4Cl)CC3)nc2N)cc1",
        "output": "871"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cc1ccnc2c([N+](=O)[O-])cccc12.NN.O>>Cc1ccnc2c(N)cccc12",
        "output": "269"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1cc(-c2ccc(C(F)(F)F)nc2)nc(-c2ccnc(-c3cccc(S(=O)(=O)NC(C)(C)C)c3)c2)n1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(-c2ccc(C(F)(F)F)nc2)nc(-c2ccnc(-c3cccc(S(N)(=O)=O)c3)c2)n1",
        "output": "680"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCC(C(=O)O)CC3)CC2)cc(C)c1OCc1ccccc1.[H][H].[Pd]>>Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCC(C(=O)O)CC3)CC2)cc(C)c1O",
        "output": "23"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1.CO.[H][H].[Pd]>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(C2CCNCC2)cc1NC(=O)C(C)C.O=Cc1ccc(Oc2ccc(F)c(F)c2)cc1>>Cc1ccc(C2CCN(Cc3ccc(Oc4ccc(F)c(F)c4)cc3)CC2)cc1NC(=O)C(C)C",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)c1cc2cc(NS(=O)(=O)c3ccc(Cl)cc3)ccc2s1.O.O.[Li+].[OH-]>>O=C(O)c1cc2cc(NS(=O)(=O)c3ccc(Cl)cc3)ccc2s1",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC[N+](CC)(CC)Cc1ccccc1.COc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O=c1c2ccccc2nc(-c2cnc3[nH]ccc3c2)n1-c1ccc(Cl)cc1.[Cl-].[Na+].[OH-]>>COc1ccc(S(=O)(=O)n2ccc3cc(-c4nc5ccccc5c(=O)n4-c4ccc(Cl)cc4)cnc32)cc1",
        "output": "354"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Clc1cc(Br)cc(Oc2c(Cl)ccc3[nH]cnc23)c1.[C-]#N.[C-]#N.[Zn+2]>>N#Cc1cc(Cl)cc(Oc2c(Cl)ccc3[nH]cnc23)c1",
        "output": "65"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CN1CCCC1CCN1C(=O)CCCc2cc([N+](=O)[O-])ccc21.[Pd]>>CN1CCCC1CCN1C(=O)CCCc2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#Cc1ccc(CO)cc1.C1CCOC1.CCI.O.[Cl-].[H-].[Na+].[Na+]>>C#Cc1ccc(COCC)cc1",
        "output": "307"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CN(C)C=O.C[C@H](CO)CBr.[Cl-].[NH4+].c1c[nH]cn1>>C[C@@H](CBr)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C",
        "output": "602"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CCOC(=O)c1cc(=O)c2c(o1)c1cc(Cl)ccc1n2C.Cl.O>>Cn1c2ccc(Cl)cc2c2oc(C(=O)O)cc(=O)c21",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CNc1nc(-c2ccc(C#N)c(F)c2)cc(N2C[C@@H](C(=O)Nc3ccccc3)OC[C@H]2C)n1.NN.O>>CNc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2C[C@@H](C(=O)Nc3ccccc3)OC[C@H]2C)n1",
        "output": "945"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](COc2cnc(Cl)c(C=O)c2)C1.N>>CC(C)(C)OC(=O)N1CC[C@@H](COc2cnc(Cl)c(CO)c2)C1",
        "output": "476"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)/C=C/c1cnc(Cl)cn1.CN(C)C=O.N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)/C=C/c1cnc(N[C@@H]2CCN(Cc3ccc(Cl)cc3)C2)cn1",
        "output": "148"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COCC1(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CCCCC1.O.[F-]>>COCC1(CO)CCCCC1",
        "output": "781"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCCCc1ccc(CN2CCC(O)(P(=O)(OCC)OCC)C2)cc1.C[Si](C)(C)I.ClC(Cl)Cl>>CCCCCCCCCc1ccc(CN2CCC(O)(P(=O)(O)O)C2)cc1",
        "output": "535"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(=O)NCc1ccc(CN2CCNCC2)cc1.Clc1cc(Cl)nc(Cl)n1.O.O=C([O-])[O-].[K+].[K+]>>CC(=O)NCc1ccc(CN2CCN(c3nc(Cl)cc(Cl)n3)CC2)cc1",
        "output": "36"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCCCCCCCCCCCOc1cccc(C(=O)O)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCCCCCCCCCCCCOc1cccc(CO)c1",
        "output": "72"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#Cc1ccc(C(=O)OC(C)C)c(CN(C)C2CC2)c1.CCCCCC.CCN(CC)CC.CCOC(C)=O.COC(=O)Cc1ccc(I)cc1F.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>COC(=O)Cc1ccc(C#Cc2ccc(C(=O)OC(C)C)c(CN(C)C3CC3)c2)cc1F",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(Cc1cccc(CO)c1)NC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12.CCO.[H][H].[Pd]>>CC(C)(Cc1cccc(CO)c1)NC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(O)c2[nH]c(=O)ccc12",
        "output": "264"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC(=N)NO.O=C(O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)N2CCC(O)C2)C1>>CCc1noc(C2CC(c3ccc(OC(F)(F)F)cc3)CN(C(=O)N3CCC(O)C3)C2)n1",
        "output": "924"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CNCCN1.CC#N.O=C(Nc1c(Cl)ccc2nc(Cl)ccc12)C1(C2CCCCC2)CC1>>O=C(Nc1c(Cl)ccc2nc(N3CCNCC3)ccc12)C1(C2CCCCC2)CC1",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C)C(=O)Cl.Oc1ccc2c(c1)N(Cc1ccccc1)CCC2.[H-].[Na+]>>CN(C)C(=O)Oc1ccc2c(c1)N(Cc1ccccc1)CCC2",
        "output": "425"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.COc1cc2ccnc(-c3ccc(F)nc3)c2cc1OC.CS(C)=O.C[C@H]1CNC[C@@H](C)O1.O>>COc1cc2ccnc(-c3ccc(N4C[C@H](C)O[C@H](C)C4)nc3)c2cc1OC",
        "output": "756"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(=O)c1cccc2ccccc12.CC(C)(C)OC(=O)NCCN.[BH3-]C#N.[Cl-].[Cl-].[Na+].[Zn+2]>>CC(NCCNC(=O)OC(C)(C)C)c1cccc2ccccc12",
        "output": "693"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(N4CCN(C)CC4)cc3)ncc2c1=O.CN.CO>>CNC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(N4CCN(C)CC4)cc3)ncc2c1=O",
        "output": "498"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.C[C@@H](NC(=O)C1(C#N)CCNCC1)c1ccc(Cl)cc1.Clc1ncnc2[nH]ccc12>>C[C@@H](NC(=O)C1(C#N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1",
        "output": "540"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCCC[C@H]1Cc1cn2ccc(C(F)(F)F)cc2n1.ClCCl.O=C(O)C(F)(F)F>>FC(F)(F)c1ccn2cc(C[C@@H]3CCCCN3)nc2c1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(CCC1CCN(c2ccncc2)CC1)Cc1ccccc1.CO>>CNCCC1CCN(c2ccncc2)CC1",
        "output": "84"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C[C@@H]1CC[C@H](Nc2ncc(-c3ccc(N4CCOCC4)cc3)c(OCC3CN(C(=O)OC(C)(C)C)C3)n2)CC1.O=C(O)C(F)(F)F>>C[C@H]1CC[C@@H](Nc2ncc(-c3ccc(N4CCOCC4)cc3)c(OCC3CNC3)n2)CC1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CI.CN(C)C=O.Cc1cc2cc(Br)ccc2[nH]1.[H-].[Na+]>>Cc1cc2cc(Br)ccc2n1C",
        "output": "191"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)C1c2nc3ccc(S(C)(=O)=O)cc3n2CCN1C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CC(C)C1NCCn2c1nc1ccc(S(C)(=O)=O)cc12",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)C(C)(C)C#N.COc1cc(C=O)ccc1Cl>>COc1cc(C=CC(=O)C(C)(C)C#N)ccc1Cl",
        "output": "295"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.COc1ccccc1N1CCNCC1.N#CCCCBr.O=C([O-])[O-].[K+].[K+]>>COc1ccccc1N1CCN(CCCC#N)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN=C=O.COc1ccc(CCNc2cc(-c3cccc(N)c3)nc(OC)n2)cc1.c1ccncc1>>CCNC(=O)Nc1cccc(-c2cc(NCCc3ccc(OC)cc3)nc(OC)n2)c1",
        "output": "176"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCOC(C)=O.CS(=O)(=O)NC(=O)c1cc(Oc2cc(C(F)(F)F)ccc2Cl)ccc1[N+](=O)[O-].CS(N)(=O)=O.O=C(O)c1cccc(Oc2cc(C(F)(F)F)ccc2Cl)c1.O=S(Cl)Cl.c1ccncc1>>CS(=O)(=O)NC(=O)c1cccc(Oc2cc(C(F)(F)F)ccc2Cl)c1",
        "output": "580"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.CCCCc1nc2c(N)nc3ccccc3c2n1CCCCON.CO>>CCCCc1nc2c(N)nc3ccccc3c2n1CCCCON=C(C)C",
        "output": "86"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3Cc2cncs2)cc1.CO.Cl.[Na+].[OH-]>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCN3Cc2cncs2)cc1",
        "output": "58"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)Cc1cccc(CO)c1.CO.[Na+].[OH-]>>O=C(O)Cc1cccc(CO)c1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN1CCNCC1.ClCCl.O.O=[N+]([O-])c1cc([N+](=O)[O-])c(Cl)c(C(F)(F)F)c1>>CCN1CCN(c2c([N+](=O)[O-])cc([N+](=O)[O-])cc2C(F)(F)F)CC1",
        "output": "105"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Br.Br.Br.CC(=O)N(C)C.Cc1nc2ccccn2c(=O)c1CCCl.O.O=C([O-])[O-].[I-].[K+].[Na+].[Na+].c1ccc2c(c1)nc(NC1CCNCC1)n2Cc1cnccn1>>Cc1nc2ccccn2c(=O)c1CCN1CCC(Nc2nc3ccccc3n2Cc2cnccn2)CC1",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CN(C)c1ccncc1.C[C@@H](O)[C@H](NC(=O)OCc1ccccc1)C(N)=O.ClCCl>>CC(=O)O[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(N)=O",
        "output": "254"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1[N+](=O)[O-].[Pd]>>COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1N",
        "output": "28"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Cc1cc(C(=O)O)ccc1[N+](=O)[O-].[Ni]>>Cc1cc(C(=O)O)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)OB(c2cccc(-c3ccco3)c2)OC1(C)C.Cc1nccc2c1[nH]c1ccc(Br)cc12>>Cc1nccc2c1[nH]c1ccc(-c3cccc(-c4ccco4)c3)cc12",
        "output": "933"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1ccc(O)cc1F.O=C(Cl)CCCCCBr>>O=C(CCCCCBr)Nc1ccc(O)cc1F",
        "output": "9"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(C=O)cc1.c1cc2[nH]ncc2cc1NC12CCC(C1)NC2>>Cc1ccc(CN2CC3(Nc4ccc5[nH]ncc5c4)CCC2C3)cc1",
        "output": "567"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCl)sc21.CN(C)C=O.CNC[C@@H](O)c1ccco1>>CCn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN(C)C[C@@H](O)c3ccco3)sc21",
        "output": "639"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.CC(=O)O.COC(=O)CC(C)C(=O)c1ccc(OC)cc1.O>>COC(=O)CC(C)C(=O)c1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccccc1N1CCc2c(Cl)nc3c(OCC(F)(F)F)cccc3c21.NCCO>>COc1ccccc1N1CCc2c(NCCO)nc3c(OCC(F)(F)F)cccc3c21",
        "output": "70"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)CBr.CN(C)C=O.CN(Cc1ccc(NC(=O)C2=Cc3cc(-c4ccc(O)cc4)ccc3S(=O)(=O)CC2)cc1)C1CCOCC1.O.O=C([O-])[O-].[K+].[K+]>>CN(Cc1ccc(NC(=O)C2=Cc3cc(-c4ccc(OCC(=O)OC(C)(C)C)cc4)ccc3S(=O)(=O)CC2)cc1)C1CCOCC1",
        "output": "393"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCC.CCOCC.Cl.FC(F)(F)c1cc(Br)ccc1Br.O.O=Cc1ccccc1.[Li]CCCC>>OC(c1ccccc1)c1ccc(Br)cc1C(F)(F)F",
        "output": "379"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(B(O)O)cc1OC.O.O=P([O-])([O-])[O-].O=[N+]([O-])c1cccnc1Cl.[K+].[K+].[K+]>>COc1ccc(-c2ncccc2[N+](=O)[O-])cc1OC",
        "output": "865"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCCO.CC#N.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=[N+]([O-])c1ccc(Br)nc1.[Cu]I>>O=[N+]([O-])c1ccc(C#CCCO)nc1",
        "output": "777"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccccc1N1CCN(C(=O)C(F)(F)F)CC1.ClCCl.O=S(=O)(O)Cl>>Cc1ccc(S(=O)(=O)Cl)cc1N1CCN(C(=O)C(F)(F)F)CC1",
        "output": "357"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNCC1.CCN(CC)CC.ClCCl.O=C(Cl)N1CCC(OC(c2ccc(Cl)cc2)c2ccccc2Cl)CC1>>O=C(N1CCCCC1)N1CCC(OC(c2ccc(Cl)cc2)c2ccccc2Cl)CC1",
        "output": "258"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(C(=O)Cl)c(OC)c1.Cl.ClCCl.Nc1nc2ccccc2s1.c1ccncc1>>COc1ccc(C(=O)Nc2nc3ccccc3s2)c(OC)c1",
        "output": "673"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC1CCNCC1.Cc1cc(Nc2ncnc3[nH]nc(OCCOS(C)(=O)=O)c23)ccc1OCc1cccc(F)c1>>COC1CCN(CCOc2n[nH]c3ncnc(Nc4ccc(OCc5cccc(F)c5)c(C)c4)c23)CC1",
        "output": "496"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)CCOc1ccc(F)cc1.CCO.[BH4-].[Na+]>>CC(O)CCOc1ccc(F)cc1",
        "output": "91"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=[N+]([O-])c1cccc(O)c1-c1ccc(OCc2ccccc2)cc1.c1ccncc1>>O=[N+]([O-])c1cccc(OS(=O)(=O)C(F)(F)F)c1-c1ccc(OCc2ccccc2)cc1",
        "output": "731"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1nc(N2CCN(Cc3ccc(C(F)F)o3)C2=O)sc1C(=O)O.Cc1nc(N2CCN(Cc3ccccc3)C2=O)sc1C(=O)O.NCc1cccnc1>>Cc1nc(N2CCN(Cc3ccc(C(F)F)o3)C2=O)sc1C(=O)NCc1cccnc1",
        "output": "534"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1csc(-c2ccc(S(N)(=O)=O)cc2)n1.CO.O>>NS(=O)(=O)c1ccc(-c2nc(C(=O)O)cs2)cc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CSc1ccc([N+](=O)[O-])c(N)c1.Cl[Sn]Cl>>CSc1ccc(N)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Cc1n[nH]c2c(=O)[nH]c3cc(Cl)ccc3c(=O)c12.ClCCl.O=C(O)C(F)(F)F>>O=C(O)Cc1n[nH]c2c(=O)[nH]c3cc(Cl)ccc3c(=O)c12",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CCn1c(C)c(C)cc(C(=O)O)c1=O.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCc1ccccc1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CCn1c(C)c(C)cc(C(=O)NCc2ccccc2)c1=O",
        "output": "790"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.COc1cccc(CC2CN(S(=O)(=O)c3cccs3)CCN2)c1.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.OC(c1ccc(Br)cc1)(C(F)(F)F)C(F)(F)F.[Cl-].[NH4+].[Na+].[Pd].[Pd]>>COc1cccc(CC2CN(S(=O)(=O)c3cccs3)CCN2c2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)c1",
        "output": "294"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)[C@@H]1CN(S(=O)(=O)c2ccccc2Cl)C(=O)N1c1ccccc1Cl.[Na+].[OH-]>>O=C(O)[C@@H]1CN(S(=O)(=O)c2ccccc2Cl)C(=O)N1c1ccccc1Cl",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)Cc1ccccc1[N+](=O)[O-].CCOC(C)=O.N#N.[Pd]>>CCOC(=O)Cc1ccccc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1oc(-c2ccc(C(=O)O)cc2)nc1CS(=O)(=O)c1ccc(F)cc1.NCc1cccnc1.O=C(Cl)C(=O)Cl>>Cc1oc(-c2ccc(C(=O)NCc3cccnc3)cc2)nc1CS(=O)(=O)c1ccc(F)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrC(Br)(Br)Br.C1CCOC1.CC(=O)Oc1c(C)cc(CO)cc1C.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(=O)Oc1c(C)cc(CBr)cc1C",
        "output": "750"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.Cl.ClCCl.NCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(Cl)c1ccc(OC(F)(F)F)cc1>>O=C1CCC(N2C(=O)c3cccc(CNC(=O)c4ccc(OC(F)(F)F)cc4)c3C2=O)C(=O)N1",
        "output": "411"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(=O)[O-].CC(=O)[O-].O.O=C([O-])[O-].O=C1COc2ncc(Br)cc2N1.OB(O)c1cccnc1.[K+].[K+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C1COc2ncc(-c3cccnc3)cc2N1",
        "output": "883"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)S(=O)(=O)c1ncccc1Br.CC1(C)OB(c2ccc(-c3cnc4[nH]ccc4c3)c(F)c2)OC1(C)C>>CC(C)S(=O)(=O)c1ncccc1-c1ccc(-c2cnc3[nH]ccc3c2)c(F)c1",
        "output": "938"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cl.NO.O.O=Cc1ccc(OCc2coc(-c3ccccc3)n2)cc1.c1ccncc1>>ON=Cc1ccc(OCc2coc(-c3ccccc3)n2)cc1",
        "output": "30"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccccc1.CN(C)C=O.COc1ncccc1-c1cc(C(C)(C)C)cc(C=O)c1O.O=C([O-])[O-].[K+].[K+]>>COc1ncccc1-c1cc(C(C)(C)C)cc(C=O)c1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(C)=O.CCO.Cl.ClCCCN1CCN(Cc2ccc(Cl)cc2)CC1.O=C([O-])[O-].Oc1cccc(O)c1.[Br-].[I-].[K+].[K+].[K+].[Na+]>>Oc1cccc(OCCCN2CCN(Cc3ccc(Cl)cc3)CC2)c1",
        "output": "74"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)NC(=O)C(C)(C)C.CC(C)N.CCN(CC)CC.O=C(Cl)c1ccccc1>>CC(C)NC(=O)c1ccccc1",
        "output": "271"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(Oc2ccccc2)cc1N.FC(F)(F)c1cc(Cl)nc(-c2cccnc2)n1>>COc1ccc(Oc2ccccc2)cc1Nc1cc(C(F)(F)F)nc(-c2cccnc2)n1",
        "output": "161"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOCCSc1cc(C)c(-c2cccc(C=O)c2)c(C)c1.CO.[BH4-].[Na+]>>CCOCCSc1cc(C)c(-c2cccc(CO)c2)c(C)c1",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1cc2c(I)c(-c3cccc(N)c3)n(C)c2cc1O.ClCCl.[Li+].[OH-]>>Cn1c(-c2cccc(N)c2)c(I)c2cc(C(=O)O)c(O)cc21",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.Cc1ccc(C(=O)O)cc1-c1cccc(N)c1.Clc1ncncc1I>>Cc1ccc(C(=O)O)cc1-c1cccc(Nc2ncncc2I)c1",
        "output": "352"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Cl.FC(F)(F)c1cnc(Cl)nc1Cl.NCc1c[n+]([O-])ccc1C(F)(F)F.O.O.[Cl-].[Na+]>>[O-][n+]1ccc(C(F)(F)F)c(CNc2ncc(C(F)(F)F)c(Cl)n2)c1",
        "output": "544"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1=CCCCC1.CCO.NC(=O)c1ccc(O)c([N+](=O)[O-])c1.[Pd]>>NC(=O)c1ccc(O)c(N)c1",
        "output": "489"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cn1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4cccc(Br)c4)c3c2)n1.FC1(F)CCNCC1>>Cn1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4cccc(N5CCC(F)(F)CC5)c4)c3c2)n1",
        "output": "953"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.COc1cc(Br)c(F)cc1-n1cnc(C)c1.N.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[C-]#N.[C-]#N.[Fe+2].[Pd].[Pd].[Zn+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1cc(C#N)c(F)cc1-n1cnc(C)c1",
        "output": "65"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cc(N)ccc1-n1cnc(C)c1.Fc1cc(Cc2ccnc(Cl)n2)cc(F)c1F>>COc1cc(Nc2nccc(Cc3cc(F)c(F)c(F)c3)n2)ccc1-n1cnc(C)c1",
        "output": "808"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O=C1CSC(=O)N1.O=Cc1ccc(SCc2ccccc2)cc1>>O=C1NC(=O)C(=Cc2ccc(SCc3ccccc3)cc2)S1",
        "output": "761"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CCOC(C)=O.CC[C@H](N)c1nc2cccc(F)c2c(=O)n1-c1ccccc1.Cc1nnc(-c2c(N)ncnc2Cl)o1>>CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(F)c2c(=O)n1-c1ccccc1",
        "output": "110"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COC(=O)Cl.Cc1nc2cccc3n(CCCCN)c(=O)c1n23.ClCCl>>COC(=O)NCCCCn1c(=O)c2c(C)nc3cccc1n32",
        "output": "94"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1CN(S(=O)(=O)c2ccc3ccccc3c2)CCN1.CCN(CC)CC.ClCCl.O=C(Cl)C1CCN(c2ccncc2)CC1>>CC1CN(S(=O)(=O)c2ccc3ccccc3c2)CCN1C(=O)C1CCN(c2ccncc2)CC1",
        "output": "125"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc(C#N)ccc1NC(=O)C1NC(CC(C)(C)C)C2(C(=O)Nc3cc(Cl)ccc32)C1c1cccc(Cl)c1F.CS(C)=O.OO.[Na+].[OH-]>>COc1cc(C(N)=O)ccc1NC(=O)C1NC(CC(C)(C)C)C2(C(=O)Nc3cc(Cl)ccc32)C1c1cccc(Cl)c1F",
        "output": "180"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CC(C)C[Al+]CC(C)C.CCOC(=O)c1[nH]c(C)nc1SCC.Cc1ccccc1.ClCCl.O.[H-]>>CCSc1nc(C)[nH]c1CO",
        "output": "286"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)C(=O)Cl.CCOCC.CS(C)=O.Cc1ccccc1.Cl.Cl[Ti](Cl)(Cl)Cl.Oc1ccccc1-c1ccccc1O>>CCN(CC)C(=O)Oc1ccccc1-c1ccccc1O",
        "output": "425"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O.O=c1[nH]c2ccc([N+](=O)[O-])cc2s1.[Cl-].[Fe].[NH4+]>>Nc1ccc2[nH]c(=O)sc2c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2cc(-c3cc4nn(Cc5ccccc5)cc4cc3F)c3c(N)ncnn23)CC1.CCOC(C)=O.ClCCl.O=C(O)C(F)(F)F>>Nc1ncnn2c(C3CCNCC3)cc(-c3cc4nn(Cc5ccccc5)cc4cc3F)c12",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCC.Cc1oc(-c2cnc(Nc3ccc4ncsc4c3)cc2NC(C)C)nc1C(=O)NCCNC(=O)OC(C)(C)C.Cl.ClCCl>>Cc1oc(-c2cnc(Nc3ccc4ncsc4c3)cc2NC(C)C)nc1C(=O)NCCN",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)Cl.N.O=C(O)[C@@H]1CC[C@@H](CNS(=O)(=O)c2cc(OCC(F)(F)F)ccc2OCC(F)(F)F)CC1>>NC(=O)[C@@H]1CC[C@@H](CNS(=O)(=O)c2cc(OCC(F)(F)F)ccc2OCC(F)(F)F)CC1",
        "output": "313"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.COc1ccc([N+](=O)[O-])cc1OCCN1CCCCC1.[Pd]>>COc1ccc(N)cc1OCCN1CCCCC1",
        "output": "202"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCC2=NCCCN2CC1.C1CCOC1.CCOC(C)=O.CS(N)(=O)=O.Cc1noc(-c2ccc(-c3ccc(C4(C(=O)O)CC4)cc3)cc2)c1C(O)c1cn(Cc2ccccc2)nn1.O.O=C(n1ccnc1)n1ccnc1.[Cl-].[NH4+]>>Cc1noc(-c2ccc(-c3ccc(C4(C(=O)NS(C)(=O)=O)CC4)cc3)cc2)c1C(O)c1cn(Cc2ccccc2)nn1",
        "output": "644"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=Cc1cccc(OCCO)c1.c1cc(NC2CCNC2)c2ccncc2c1>>OCCOc1cccc(CN2CCC(Nc3cccc4cnccc34)C2)c1",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cl.Nc1cccc(O)c1.O=N[O-].[N-]=[N+]=[N-].[Na+].[Na+]>>[N-]=[N+]=Nc1cccc(O)c1",
        "output": "189"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)OC1(CCCN=[N+]=[N-])CCCCC1.CCO.[Pd]>>CC(C)(C)[Si](C)(C)OC1(CCCN)CCCCC1",
        "output": "89"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].COC(=O)c1ccc(CO)cc1.Cc1ccccc1.Fc1cc2nc(-c3cccnc3Cl)n(CC3CCCCC3)c2cc1F.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COC(=O)c1ccc(COc2ncccc2-c2nc3cc(F)c(F)cc3n2CC2CCCCC2)cc1",
        "output": "433"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOCC.COC(=O)c1c(C)cccc1C.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)c1c(C)cccc1CBr",
        "output": "545"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(C)=O.CCn1nnc(-c2ccc(C(C)(c3ccc(C(O)Cc4ccccn4)cc3)C(C)C)cc2)n1.CI.C[Si](C)(C)[N-][Si](C)(C)C.[Na+]>>CCn1nnc(-c2ccc(C(C)(c3ccc(C(Cc4ccccn4)OC)cc3)C(C)C)cc2)n1",
        "output": "140"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(O)CCCCCCOCc1cc(C(F)(F)F)cc(C(F)(F)F)c1.CCN(CC)CC.CS(C)=O.O=C(Cl)C(=O)Cl>>CC(=O)CCCCCCOCc1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "87"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cc1cc([N+](=O)[O-])cc(C#N)c1Oc1ccc(O)c(C(C)C)c1>>Cc1cc(N)cc(C#N)c1Oc1ccc(O)c(C(C)C)c1",
        "output": "335"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=Cc1cc(N(C)C)ccc1-c1ccc([C@]2(O)C[C@@H](C(=O)OC)N(C(=O)OCC[Si](C)(C)C)C2)cc1.CI.CN(C)C=O.[H-].[Na+]>>C=Cc1cc(N(C)C)ccc1-c1ccc([C@]2(OC)C[C@@H](C(=O)OC)N(C(=O)OCC[Si](C)(C)C)C2)cc1",
        "output": "140"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1nc(C(F)(F)F)ccc1C(=O)Nc1ccc(Cl)c(N)c1.O=C(Cl)c1ccc(Cl)cc1>>Cc1nc(C(F)(F)F)ccc1C(=O)Nc1ccc(Cl)c(NC(=O)c2ccc(Cl)cc2)c1",
        "output": "11"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.CO.COCCNc1cc(NC(=O)N2CCCc3cc(C(C)O)c(C(OC)OC)nc32)ncc1C#N.CS(=O)(=O)Cl.ClCCl>>COCCNc1cc(NC(=O)N2CCCc3cc(C(C)OS(C)(=O)=O)c(C(OC)OC)nc32)ncc1C#N",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)CCc1ccccc1Cl.[Na+].[OH-]>>O=C(O)CCc1ccccc1Cl",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc2c(cc1OC)C(Cc1ccccc1)NCC2.NC1CCCc2ccccc21.O=C(Br)CBr>>COc1cc2c(cc1OC)C(Cc1ccccc1)N(CC(=O)NC1CCCc3ccccc31)CC2",
        "output": "946"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CN1Cc2ccc(Cl)nc2O[C@H](c2ccccc2)C1.COc1nc(N)ccc1-c1cnc(C)o1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2]>>COc1nc(Nc2ccc3c(n2)O[C@H](c2ccccc2)CN(C)C3)ccc1-c1cnc(C)o1",
        "output": "606"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)[C@@H]1CCNC1.COc1c(NC(=O)c2cc3cccc(CN4CCC(C(=O)O)CC4)c3n2C)cc(C(C)(C)C)cc1NS(C)(=O)=O>>COc1c(NC(=O)c2cc3cccc(CN4CCC(C(=O)N5CC[C@@H](N(C)C)C5)CC4)c3n2C)cc(C(C)(C)C)cc1NS(C)(=O)=O",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOCC.O.O=C(O)c1ccc(-c2ccccn2)nc1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OCc1ccc(-c2ccccn2)nc1",
        "output": "293"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)O.CC(C)(C)OC(=O)N1CCc2c(ncnc2Oc2ccc3c(ccn3C(=O)Nc3cc(CO[Si](C)(C)C(C)(C)C)cc(C(F)(F)F)c3)c2)C1.CCOC(C)=O.O>>CC(C)(C)OC(=O)N1CCc2c(ncnc2Oc2ccc3c(ccn3C(=O)Nc3cc(CO)cc(C(F)(F)F)c3)c2)C1",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1ccc(OCC(F)(F)F)c(C(C)(C)C)c1.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O.O=C1CCC(=O)N1I>>CC(C)(C)c1cc(I)c(OCC(F)(F)F)c(C(C)(C)C)c1",
        "output": "834"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CCC=O.N#Cc1cnc2c(Cl)cc(NCc3cn(C4CCNCC4)nn3)cc2c1Nc1ccc(F)c(Cl)c1.[Na+]>>CCCN1CCC(n2cc(CNc3cc(Cl)c4ncc(C#N)c(Nc5ccc(F)c(Cl)c5)c4c3)nn2)CC1",
        "output": "484"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CN(C)C=O.CN(C)c1ccncc1.O.O=C1NC[C@@H](CO)O1.c1c[nH]cn1>>CC(C)(C)[Si](OC[C@@H]1CNC(=O)O1)(c1ccccc1)c1ccccc1",
        "output": "602"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.COC(=O)C1CS(=O)(=O)CC(Cc2ccc(OC)c(Br)c2)C1O.Cl.[Na+].[OH-]>>COc1ccc(CC2CS(=O)(=O)CC(C(=O)O)C2O)cc1Br",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COC(=O)[C@H](Cc1ccc(C=CCCc2cccc(N(C)C(=O)OC(C)(C)C)n2)cc1)NC(=O)OC(C)(C)C.[Pd]>>COC(=O)[C@H](Cc1ccc(CCCCc2cccc(N(C)C(=O)OC(C)(C)C)n2)cc1)NC(=O)OC(C)(C)C",
        "output": "362"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1cc(C)nc(OCc2ccccc2)c1C=O.CO.[BH4-].[Na+]>>CCc1cc(C)nc(OCc2ccccc2)c1CO",
        "output": "476"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.Cc1c(Cn2c(CN3C(=O)c4ccccc4C3=O)nc(=O)c3sc(N4CCOCC4)nc32)cccc1C(F)(F)F.NN>>Cc1c(Cn2c(CN)nc(=O)c3sc(N4CCOCC4)nc32)cccc1C(F)(F)F",
        "output": "242"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)CCOc1cc(N)ccc1I.Cc1c(S(=O)(=O)Cl)sc2ccc(Cl)cc12>>Cc1c(S(=O)(=O)Nc2ccc(I)c(OCCN(C)C)c2)sc2ccc(Cl)cc12",
        "output": "861"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.COCCCOc1ccc(Br)c(CCO[Si](C(C)C)(C(C)C)C(C)C)c1.[Li]CCCC>>COCCCOc1ccc(B(O)O)c(CCO[Si](C(C)C)(C(C)C)C(C)C)c1",
        "output": "832"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.O=Cc1c(Cl)ncc2ccccc12.[BH4-].[Na+]>>OCc1c(Cl)ncc2ccccc12",
        "output": "476"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.ClCCl.Cn1c(=O)c(F)c(Nc2ccc(C#C[Si](C)(C)C)cc2F)c2c(=O)n(C[C@H](O)CO)cnc21.[F-]>>C#Cc1ccc(Nc2c(F)c(=O)n(C)c3ncn(C[C@H](O)CO)c(=O)c23)c(F)c1",
        "output": "337"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[O-].CO.COC(=O)C1CC(c2ccc(OC(F)(F)F)c(F)c2)CN(C(=O)OC(C)(C)C)C1.[K+]>>CC(C)(C)OC(=O)N1CC(C(=O)O)CC(c2ccc(OC(F)(F)F)c(F)c2)C1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)NC1C2CC3CC1CC(C(=O)O)(C3)C2.CCN=C=NCCCN(C)C.ClCCl.N.O.On1nnc2ccccc21>>CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2",
        "output": "313"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NCC1CCc2cc(O)ccc21.CS(C)=O.NC(=O)c1ccc(Cl)nc1.O=C([O-])[O-].[Cl-].[K+].[K+].[NH4+]>>CC(C)(C)OC(=O)NCC1CCc2cc(Oc3ccc(C(N)=O)cn3)ccc21",
        "output": "516"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccsc1C(=O)O.NCc1ccc(F)cc1>>Cc1ccsc1C(=O)NCc1ccc(F)cc1",
        "output": "950"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCCCCCCCCCCCCCc1ccsc1.ClC(Cl)Cl.O=C1CCC(=O)N1Br>>CCCCCCCCCCCCCCc1ccsc1Br",
        "output": "807"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1ccccc1CCl.Cc1ccc(Nc2cc(N(C)C)nc(N3CCNCC3)n2)cc1.O=C([O-])O.[Na+]>>COc1ccccc1CN1CCN(c2nc(Nc3ccc(C)cc3)cc(N(C)C)n2)CC1",
        "output": "156"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCc1cc(C(=O)c2ccccc2Cl)c(-n2c(C)nnc2CO)s1.ClC(Cl)Cl.O.O=C(Cl)c1ccc(Cl)c(Cl)c1>>CCc1cc(C(=O)c2ccccc2Cl)c(-n2c(C)nnc2COC(=O)c2ccc(Cl)c(Cl)c2)s1",
        "output": "51"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.Nc1cccc(Cl)c1[N+](=O)[O-]>>CC(C)(C)OC(=O)N1CCN(c2cccc(N)c2[N+](=O)[O-])CC1",
        "output": "105"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.O.[N-]=[N+]=NCCCCc1ccc(CC(=O)O)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NCCCCc1ccc(CC(=O)O)cc1",
        "output": "89"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCN1.CN(C)C=O.Cc1ccc(-c2cc(C#N)c(Cl)nc2-c2ccccc2)cc1>>Cc1ccc(-c2cc(C#N)c(N3CCOCC3)nc2-c2ccccc2)cc1",
        "output": "220"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCCOc1ccc2c(c1)c(CC(=O)NN)c(C)n2Cc1ccccc1.Cl.O.[Na+].[OH-]>>Cc1c(CC(=O)NN)c2cc(OCCCC(=O)O)ccc2n1Cc1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1nc2c(C)ccnc2n1Cc1ccc2nn(-c3ccccc3C(=O)OCC)c(Br)c2c1.CCO.O.[Na+].[OH-]>>CCCc1nc2c(C)ccnc2n1Cc1ccc2nn(-c3ccccc3C(=O)O)c(Br)c2c1",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)C1(NC(=O)OC(C)(C)C)CN(C(=O)OC(C)(C)C)C1.Cl.O.[BH4-].[Li+]>>CC(C)(C)OC(=O)NC1(CO)CN(C(=O)OC(C)(C)C)C1",
        "output": "225"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)CCNC(=O)[C@@H](N)Cc1ccccc1.CN(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)O.O>>CC(C)CCNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CN(C)C)NC(=O)OC(C)(C)C",
        "output": "133"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)[C@H]1CC[C@@H](c2ccc(Nc3nc(Nc4ccc(CP(=O)(OCC)OCC)cc4OCC)ncc3C(F)(F)F)c3c2CN(C)C3=O)CC1.CO.O.O.[Li+].[OH-]>>CCOc1cc(CP(=O)(OCC)OCC)ccc1Nc1ncc(C(F)(F)F)c(Nc2ccc([C@@H]3CC[C@H](C(=O)O)CC3)c3c2C(=O)N(C)C3)n1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCN.O=S(=O)(Cl)c1cccs1>>COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCNS(=O)(=O)c1cccs1",
        "output": "600"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)c1cc(CC(=O)O)cc(C(C)(C)C)c1O.CCO.Cl>>CCOC(=O)Cc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.ClCc1ccc2ccccc2n1.O=[N+]([O-])c1cc(O)ccc1Cl>>O=[N+]([O-])c1cc(OCc2ccc3ccccc3n2)ccc1Cl",
        "output": "616"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.COC(=O)[C@@H]1CC[C@@H](N)CC1.Cl.ClCCl.O=C(Cl)CCCCl>>COC(=O)[C@@H]1CC[C@@H](NC(=O)CCCCl)CC1",
        "output": "45"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CC(O)CC#Cc1ccccc1S(N)(=O)=O.c1ccncc1>>CC(=O)OC(C)CC#Cc1ccccc1S(N)(=O)=O",
        "output": "254"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1ccc(O)c(C=O)c1.CN(C)c1ccncc1.COc1cc2nccc(Cl)c2cc1OC.Clc1ccccc1.O>>COc1cc2nccc(Oc3ccc(C(C)(C)C)cc3C=O)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1c2n(c3c(Br)cc(C#N)cc13)CCNC2=O.O=[N+]([O-])c1ccc(B(O)O)cc1>>Cc1c2n(c3c(-c4ccc([N+](=O)[O-])cc4)cc(C#N)cc13)CCNC2=O",
        "output": "833"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(F)ccc1-c1cc[nH]c(=O)c1.Cn1c2c(c3ccc(Br)cc31)CN(C(=O)OC(C)(C)C)CC2>>COc1cc(F)ccc1-c1ccn(-c2ccc3c4c(n(C)c3c2)CCN(C(=O)OC(C)(C)C)C4)c(=O)c1",
        "output": "982"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)c1ccc(-c2ccc(CCCN(C[C@H](O)c3ccc(Cl)nc3)C(=O)OC(C)(C)C)cc2)c(OC)c1.CCOC(C)=O.Cl.[Na+].[OH-]>>COc1cc(C(=O)O)ccc1-c1ccc(CCCN(C[C@H](O)c2ccc(Cl)nc2)C(=O)OC(C)(C)C)cc1",
        "output": "5"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CNCCOC.ClCCl.O.O=C(Cl)N1CCC2C(C#Cc3cccc(Cl)c3)=NOC21>>COCCN(C)C(=O)N1CCC2C(C#Cc3cccc(Cl)c3)=NOC21",
        "output": "258"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)CC(c2cccc(C(F)(F)F)c2)c2ccc(O)cc2O1.ClCC1CO1>>CC1(C)CC(c2cccc(C(F)(F)F)c2)c2ccc(OCC3CO3)cc2O1",
        "output": "15"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCO.OC[C@H]1O[C@@H](n2cnc3c(NN4CCCCC4)nc(Cl)nc32)[C@H](O)[C@@H]1O.[Na+].[OH-]>>CCCOc1nc(NN2CCCCC2)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1",
        "output": "213"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(C)=O.O=[N+]([O-])c1cnc2cnn(C3CCCCO3)c2c1.[H][H].[Pd]>>Nc1cnc2cnn(C3CCCCO3)c2c1",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1cn(Cc2ccccc2)nc1OCc1ccc(OC)c(OCc2nc(-c3ccco3)oc2C)c1.CCOC(C)=O.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>COc1ccc(COc2nn(Cc3ccccc3)cc2CO)cc1OCc1nc(-c2ccco2)oc1C",
        "output": "471"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cl.Nc1c(F)cccc1C(=O)O.O.O=C1CCC(=O)N1Cl>>Nc1c(F)cc(Cl)cc1C(=O)O",
        "output": "121"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1cn([C@@H](C)CN(C)C(=O)OC(C)(C)C)c2c(F)c(C3(NC(=O)OCc4ccccc4)CC3)c(F)cc2c1=O.CCOC(C)=O.O.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CCOC(=O)c1cn([C@@H](C)CNC)c2c(F)c(C3(NC(=O)OCc4ccccc4)CC3)c(F)cc2c1=O",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.CNC1CN(c2nc3ncc(OC)cc3n3cnnc23)C1.CO.ClCCl>>CNC1CN(c2nc3ncc(O)cc3n3cnnc23)C1",
        "output": "424"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#CCOc1ncnc(Cl)c1F.CC#N.CC1(C)CNCC(C)(C)C1.Cl.O=C([O-])[O-].[Cl-].[NH4+]>>CC#CCOc1ncnc(N2CC(C)(C)CC(C)(C)C2)c1F",
        "output": "296"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC(O)C(F)(F)C(=O)O.CO.Cc1ccc(S(=O)(=O)O)cc1.O.O=C([O-])O.[Na+]>>CCCC(O)C(F)(F)C(=O)OC",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(CCCC#N)cc1.ClCCl.O=C(O)C(F)(F)F>>N#CCCCc1ccc(N)cc1",
        "output": "782"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COc1ccc(C2(CCO)CCN(C(=O)c3cc(-n4cnnn4)ccc3OC)C2)cc1OC.CS(=O)(=O)Cl.ClCCl>>COc1ccc(C2(CCOS(C)(=O)=O)CCN(C(=O)c3cc(-n4cnnn4)ccc3OC)C2)cc1OC",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CCNCC1.Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(Cc3ccc(S(C)(=O)=O)cc3)cc(C=O)c2c1>>Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(Cc3ccc(S(C)(=O)=O)cc3)cc(CN3CCN(C)CC3)c2c1",
        "output": "757"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(O)C1CCC(Nc2cc(Cl)cc3cc(-c4ccccc4)[nH]c23)CC1.[Cl-].[NH4+]>>NC(=O)C1CCC(Nc2cc(Cl)cc3cc(-c4ccccc4)[nH]c23)CC1",
        "output": "313"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOCC.CN(C)C(=O)C1CCN1C(c1ccccc1)c1ccccc1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CN(C)CC1CCN1C(c1ccccc1)c1ccccc1",
        "output": "490"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.C1CCOC1.N#CC(c1ccc(Cl)cc1)C1(O)CCCCC1.O.O=S(=O)(O)O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>NCC(c1ccc(Cl)cc1)C1(O)CCCCC1",
        "output": "246"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COC(=O)Cl.ClCCl.NC[C@@H]1C[C@@H](n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc32)C1>>COC(=O)NC[C@@H]1C[C@@H](n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc32)C1",
        "output": "94"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COCCOCCO.F[B-](F)(F)F.Nc1c(Cl)cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCN(C3CCN(CC(=O)O)CC3)CC2)cc1C(F)(F)F>>COCCOCCOC(=O)CN1CCC(N2CCN(C(=O)[C@@H](Cc3cc(Cl)c(N)c(C(F)(F)F)c3)OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)CC1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CON.Cl.O=Cc1ccc(F)cc1C(F)(F)F>>CON=Cc1ccc(F)cc1C(F)(F)F",
        "output": "30"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1ccc2c(c1)C(=O)CC(C)(COc1ccc([N+](=O)[O-])cc1)O2.[Pd].c1ccccc1>>COC(=O)c1ccc2c(c1)C(=O)CC(C)(COc1ccc(N)cc1)O2",
        "output": "202"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCCCBr.C1CCOC1.CN(C)C=O.COCOC1CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@]12C.[Cl-].[H-].[NH4+].[Na+]>>COCOC1CC[C@H]2[C@@H]3CCc4cc(OCCCBr)ccc4[C@H]3CC[C@]12C",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1c(F)cc(O)cc1F.Oc1nc(Cl)nc2cnccc12>>COc1c(F)cc(Oc2nc(O)c3ccncc3n2)cc1F",
        "output": "542"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(N)cc1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.O.O=C(O)c1cccc(Cc2ccccc2)c1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(NC(=O)c2cccc(Cc3ccccc3)c2)cc1",
        "output": "50"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Clc1ccnc2ncccc12.Nc1cc(OCc2ccc(F)cc2)ccc1Sc1ccc(O)cc1>>Oc1ccc(Sc2ccc(OCc3ccc(F)cc3)cc2Nc2ccnc3ncccc23)cc1",
        "output": "922"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCc1ccccc1.CC(C)=O.CCN(CC)c1ccc(C=O)c(O)c1.O=C([O-])[O-].[K+].[K+]>>CCN(CC)c1ccc(C=O)c(OCc2ccccc2)c1",
        "output": "127"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN.O=C(O)c1ccc(Cl)c([N+](=O)[O-])c1.O=S(=O)(O)O>>CNc1ccc(C(=O)O)cc1[N+](=O)[O-]",
        "output": "304"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CI.C[Si](C)(C)CCOCn1cc(C(F)(F)F)nc1C1(O)CCOCC1.[H-].[Na+]>>COC1(c2nc(C(F)(F)F)cn2COCC[Si](C)(C)C)CCOCC1",
        "output": "140"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)CN(C(=O)OC(C)(C)C)c1cccc(C(Cc2ccc(Br)cc2)NS(=O)(=O)c2ccccn2)n1.CC(C)(C)PC(C)(C)C.CC(C)(C)[O-].Cc1ccccc1.Nc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Cl-].[NH4+].[Na+].[Pd].[Pd].c1ccc(-c2ccccc2)cc1>>CC(C)(C)OC(=O)CN(C(=O)OC(C)(C)C)c1cccc(C(Cc2ccc(Nc3ccccc3)cc2)NS(=O)(=O)c2ccccn2)n1",
        "output": "405"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COc1ccc(/C(C#N)=C/c2ccc(N3CCC(O)CC3)s2)cc1OC.ClC(Cl)Cl.O.O=C(Cl)CBr.[H-].[Na+]>>COc1ccc(/C(C#N)=C/c2ccc(N3CCC(OC(=O)CBr)CC3)s2)cc1OC",
        "output": "126"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1cnnn1C.CO.[Na+].[OH-]>>Cn1nncc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCCC1=O.CS(=O)(=O)NC1CCC(N)CC1.CS(=O)c1nccc(-c2cnc3c(C(C)(C)O)cccn23)n1.O>>CC(C)(O)c1cccn2c(-c3ccnc(NC4CCC(NS(C)(=O)=O)CC4)n3)cnc12",
        "output": "666"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1nccn1-c1ccc(C(=O)O)cc1.Clc1cnc(N2CCC(NC3CC3)CC2)nc1.O.O=C(O)C(F)(F)F.On1nnc2ccccc21>>Cc1nccn1-c1ccc(C(=O)N(C2CC2)C2CCN(c3ncc(Cl)cn3)CC2)cc1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccnc(NC4CCCCC4)c3)cc3c2CNC3=O)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C1NCc2c1cc(-c1ccnc(NC3CCCCC3)c1)nc2N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CNCCN1.COc1ccc(S(=O)(=O)N2CCN(C[C@H](O)COc3ccc(OCc4ccccc4)cc3)CC2)cc1.ClCCl.[Br-].[K+].[Pd]>>COc1ccc(S(=O)(=O)N2CCN(C[C@H](O)COc3ccc(O)cc3)CC2)cc1",
        "output": "23"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cc1cccc(N)c1.N#Cc1cnc2ccc([N+](=O)[O-])cc2c1Cl.O=C([O-])O.[Na+]>>Cc1cccc(Nc2c(C#N)cnc3ccc([N+](=O)[O-])cc23)c1",
        "output": "115"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)N.CCN(CC)CC.ClCCl.O=C(Cl)c1ccc(Br)cc1F>>CC(C)(C)NC(=O)c1ccc(Br)cc1F",
        "output": "271"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1c(Cl)cc(Br)cc1Cl.OB(O)c1ccccc1Cl>>Nc1c(Cl)cc(-c2ccccc2Cl)cc1Cl",
        "output": "837"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCCCCN(CCC12CC3CC(CC(C3)C1)C2)C(=O)NCCC(O)c1ccncc1.CCOC(C)=O.ClCCl.O.O=C([O-])O.O=S([O-])[O-].[Na+].[Na+].[Na+]>>CCCCCN(CCC12CC3CC(CC(C3)C1)C2)C(=O)NCCC(=O)c1ccncc1",
        "output": "32"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCC(C(=O)OC)c1c(C)nc(N2CCCC(Oc3ccccc3)C2)nc1-c1ccc(C)cc1.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc(N2CCCC(Oc3ccccc3)C2)nc1-c1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@H](Cc1ccc(N)cc1)C(=O)O.CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.On1nnc2ccccc21>>CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc(C[C@@H](NC(=O)OC(C)(C)C)C(=O)O)cc1",
        "output": "365"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)C(=O)Nc1cccc(C2CCN(CCN)CC2)c1.O=C=Nc1ccc(-c2ccccc2)cc1>>CC(C)C(=O)Nc1cccc(C2CCN(CCNC(=O)Nc3ccc(-c4ccccc4)cc3)CC2)c1",
        "output": "35"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CSc1nc(Cl)c2ccc(=O)n(-c3c(F)cccc3F)c2n1.ClCCl.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nc(Cl)c2ccc(=O)n(-c3c(F)cccc3F)c2n1",
        "output": "595"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=C(CCO)c1ccc(F)c(Br)c1.CC(C)(C)[Si](C)(C)Cl.CCOC(C)=O.ClCCl.O.c1c[nH]cn1>>C=C(CCO[Si](C)(C)C(C)(C)C)c1ccc(F)c(Br)c1",
        "output": "193"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCCCCOc1ccc2c(-c3ccc(Br)cc3)csc2c1.CCO.CNC>>CN(C)CCCCOc1ccc2c(-c3ccc(Br)cc3)csc2c1",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)Cl.N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2C(=O)C2(N3CCNCC3)CC2)CC1>>COC(=O)N1CCN(C2(C(=O)N3C[C@H](S(=O)(=O)c4ccccc4Cl)C[C@H]3C(=O)NC3(C#N)CC3)CC2)CC1",
        "output": "219"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1ccc(CC(=O)O)cc1.CCN(C(C)C)C(C)C.CN(C)C=O.C[C@@H](N)c1ncc(Br)s1.Cl.ClCCCl.ClCCl.On1nnc2cccnc21>>CC(C)c1ccc(CC(=O)N[C@H](C)c2ncc(Br)s2)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)[O-].CCOC(C)=O.COc1ccc2nc(Cl)cc(C)c2c1.N[C@H]1CCN(Cc2ccccc2)C1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>COc1ccc2nc(N[C@H]3CCN(Cc4ccccc4)C3)cc(C)c2c1",
        "output": "70"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc2ncc(SCCN3CCC(N)CC3)nc2c1.O=Cc1ccc2c(c1)OCCO2>>COc1ccc2ncc(SCCN3CCC(NCc4ccc5c(c4)OCCO5)CC3)nc2c1",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCOC(=O)Cc1ccc(Oc2ccc(C(=O)NCCc3ccc(Cl)cc3)cc2)c(CC)c1.CCOC(C)=O.Cl.O.[Na+].[OH-]>>CCc1cc(CC(=O)O)ccc1Oc1ccc(C(=O)NCCc2ccc(Cl)cc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.O=C(C(C(=O)c1cccc(CO)c1)=C1Nc2ccccc2N1)c1cc(F)cc(F)c1.[Mn+4].[O-2].[O-2]>>O=Cc1cccc(C(=O)C(C(=O)c2cc(F)cc(F)c2)=C2Nc3ccccc3N2)c1",
        "output": "179"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cl.N#Cc1ccc2c(c1)CC(=O)N2.[H][H]>>NCc1ccc2c(c1)CC(=O)N2",
        "output": "175"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.COc1ccc(CN(c2nc(Cl)nn3c(C#N)cnc23)C2CC2)cc1.N#Cc1cc(N)c(F)cc1F.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].[Pd+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1ccc(CN(c2nc(Nc3cc(C#N)c(F)cc3F)nn3c(C#N)cnc23)C2CC2)cc1",
        "output": "990"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.CCOC(C)=O.COc1ccc(Cl)cc1-c1ccncc1.ClCCl>>Oc1ccc(Cl)cc1-c1ccncc1",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCNCc1cccn1C.COc1ccc(N(CC(=O)O)S(=O)(=O)c2ccccc2C)cn1>>CCN(Cc1cccn1C)C(=O)CN(c1ccc(OC)nc1)S(=O)(=O)c1ccccc1C",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Fc1ccc(F)c(CBr)c1.O=Cc1c[nH]c2ccccc12>>O=Cc1cn(Cc2cc(F)ccc2F)c2ccccc12",
        "output": "528"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)NCC1(N2CCN(C)CC2)CCCCC1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCNCC1(N2CCN(C)CC2)CCCCC1",
        "output": "112"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1cncc(-c2ncnc3ccc(Br)cc23)c1>>CC(=O)N1CCN(C(=O)c2cncc(-c3ncnc4ccc(Br)cc34)c2)CC1",
        "output": "256"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCN(CC1CC1)c1ccc(C(F)(F)F)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ncc(OCCCC(=O)OCC)cn1.CCO.CCOC(C)=O.[Na+].[OH-]>>CCCN(CC1CC1)c1ccc(C(F)(F)F)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ncc(OCCCC(=O)O)cn1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.C1=CCCCC1.COc1ccc(S(=O)(=O)N2c3ccc(Br)cc3-c3ccccc3C2C)cc1F.ClCCl>>CC1c2ccccc2-c2cc(Br)ccc2N1S(=O)(=O)c1ccc(O)c(F)c1",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1CCNCC1.O=C(O)C1CCCN(S(=O)(=O)c2ccccc2Cl)C1>>CC1CCN(C(=O)C2CCCN(S(=O)(=O)c3ccccc3Cl)C2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClCCl.O=C(NCCCCc1cccnc1)c1ccc(-c2ccc([N+](=O)[O-])cc2)cc1.O=S(Cl)Cl.OCCCCCc1ccccn1.[Na+].[OH-]>>ClCCCCCc1ccccn1",
        "output": "96"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C1CNCCN1.CCN(CC)CC.O=[N+]([O-])c1ccc2nc(Cl)sc2c1>>O=[N+]([O-])c1ccc2nc(N3CCNCC3)sc2c1",
        "output": "558"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1nc(N2CCN(Cc3cccc4cccnc34)C2=O)sc1C(=O)O.Cc1nc(N2CCN(Cc3csc4ccc(Cl)cc34)C2=O)sc1C(=O)O.NCc1cccnc1>>Cc1nc(N2CCN(Cc3cccc4cccnc34)C2=O)sc1C(=O)NCc1cccnc1",
        "output": "534"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C(O)C(F)(F)F.O=C1CCC(C(=O)O)CC1.O=c1c2cnn(-c3ccc(F)cc3)c2ncn1CC1(O)CCNCC1>>O=C1CCC(C(=O)N2CCC(O)(Cn3cnc4c(cnn4-c4ccc(F)cc4)c3=O)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNOC.Cl.ClCCCl.O=C(O)c1ccc([N+](=O)[O-])cc1F.On1nnc2ccccc21.c1ccncc1>>CON(C)C(=O)c1ccc([N+](=O)[O-])cc1F",
        "output": "828"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOP(=O)(CCN1CC(O)CNc2c1c(=O)c2=O)OCC.C[Si](C)(C)Br.ClCCCl.O>>O=c1c2c(c1=O)N(CCP(=O)(O)O)CC(O)CN2",
        "output": "535"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc2cc(Nc3cc(C)[nH]n3)nc(O)c2cc1F.O=P(Cl)(Cl)Cl>>COc1cc2cc(Nc3cc(C)[nH]n3)nc(Cl)c2cc1F",
        "output": "41"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOCC.COC(=O)c1cccn2c(C)c(C)cc12.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1cc2c(CO)cccn2c1C",
        "output": "522"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Nc1ccc(Cl)cc1N1CCN(CCC(F)(F)F)CC1.O=C(O)c1ccc(-n2cncn2)cc1>>O=C(Nc1ccc(Cl)cc1N1CCN(CCC(F)(F)F)CC1)c1ccc(-n2cncn2)cc1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC(=O)C(=CNc1ccccc1C(C)O)C(=O)OCC.ClCCl.O=C(Cl)c1ccccc1.c1ccncc1>>CCCC(=O)C(=CNc1ccccc1C(C)OC(=O)c1ccccc1)C(=O)OCC",
        "output": "51"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCC[C@H](CC(=O)OCC)C(=O)O.CN1CCOCC1.Cl.ClCCCl.ClCCl.N[C@@H](Cc1csc2ccccc12)C(=O)NC1Cc2ccccc2C1.On1nnc2ccccc21>>CCCC[C@H](CC(=O)OCC)C(=O)N[C@@H](Cc1csc2ccccc12)C(=O)NC1Cc2ccccc2C1",
        "output": "133"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1cnc(-c2ccccc2)cc1C(=O)N1CCC(N2CCCC3(C2)CC(C)(C)OC3=O)CC1.CC(C)OC(C)C>>CC1(C)CC2(CCCN(C3CCN(C(=O)c4cc(-c5ccccc5)ncc4N)CC3)C2)C(=O)O1",
        "output": "877"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)O)cn3)nc2n1C1CCCC1.OCCN1C2CCC1CNC2>>CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5CCO)cn3)nc2n1C1CCCC1",
        "output": "256"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCCOc1ccccc1F>>COc1cc2nccc(Oc3cc(C)c(NC(=O)OCCOc4ccccc4F)cc3C)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NCCCN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1.Cl>>NCCCN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1",
        "output": "538"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCCCC2c2coc3cccc-3c2)CC1.O=C(O)c1cnc(N2CCOCC2)cn1>>O=C(N[C@@H]1CC[C@@H](CCN2CCCCC2c2coc3cccc-3c2)CC1)c1cnc(N2CCOCC2)cn1",
        "output": "697"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].CCOC(C)=O.COC(=O)c1cc(C)c(-c2ccc(OC)nc2)c(C)c1.[K+].[Na+].[OH-]>>COC(=O)c1cc(C)c(-c2cnc(OC)c(Br)c2)c(C)c1",
        "output": "292"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.CO[Na].O=[N+]([O-])c1c(F)cccc1F.[Na]>>COc1cccc(F)c1[N+](=O)[O-]",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[O-].CC(C)(C)[Si](C)(C)OC[C@@H]1CN2CCOC[C@@H]2CN1.Cc1ccccc1.Cc1ccncc1-c1cc(Cl)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.[Na+]>>Cc1ccncc1-c1cc(N2C[C@H]3COCCN3C[C@H]2CO[Si](C)(C)C(C)(C)C)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "220"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCC1CCCO1.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].Oc1cccc(Br)c1F.[K+].[K+]>>Fc1c(Br)cccc1OCC1CCCO1",
        "output": "18"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCNCc1cccc(C)n1.COc1ccccc1N(CC(=O)O)S(=O)(=O)c1ncccc1C>>CCN(Cc1cccc(C)n1)C(=O)CN(c1ccccc1OC)S(=O)(=O)c1ncccc1C",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1ccc(Oc2ccc(CNC(=O)C3(N)CC3)cc2)c(C(F)(F)F)c1.F[B-](F)(F)F.O=C(O)C(F)(F)F.O=C(O)c1cccc(O)n1>>COc1ccc(Oc2ccc(CNC(=O)C3(NC(=O)c4cccc(O)n4)CC3)cc2)c(C(F)(F)F)c1",
        "output": "738"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCCBr.CC(=O)c1cc([N+](=O)[O-])c(O)c(C(C)(C)C)c1.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1cc([N+](=O)[O-])c(OCCBr)c(C(C)(C)C)c1",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC1(C)OB(c2ccc(N3CC(CO)OC3=O)cc2F)OC1(C)C.COCn1cc(Nc2ccc(Br)cn2)nn1.Cl[Pd]Cl.O.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COCn1cc(Nc2ccc(-c3ccc(N4CC(CO)OC4=O)cc3F)cn2)nn1",
        "output": "938"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cc1ccc(F)c([N+](=O)[O-])c1.c1c[nH]cn1>>Cc1ccc(-n2ccnc2)c([N+](=O)[O-])c1",
        "output": "721"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cccc(-c2ccc3cc[nH]c3c2)c1.O=C(O)c1cc2cccc(O)c2oc1=O>>O=C(Nc1cccc(-c2ccc3cc[nH]c3c2)c1)c1cc2cccc(O)c2oc1=O",
        "output": "799"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)CCc1cccc(-c2nc(=O)c3ccccc3s2)n1.CC(C)OC(C)C.O=C(O)C(F)(F)F>>O=C(O)CCc1cccc(-c2nc(=O)c3ccccc3s2)n1",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "NCC1(c2ccc(C(F)(F)F)nc2)CCC(F)(F)CC1.O=C(O)c1cccc(F)c1Cl>>O=C(NCC1(c2ccc(C(F)(F)F)nc2)CCC(F)(F)CC1)c1cccc(F)c1Cl",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCn2c(Cl)cnc2C1.Cl>>Clc1cnc2n1CCNC2",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)[O-].CI.O.O=C1c2cc(Br)ccc2CC12CCC(O)CC2.[K+]>>COC1CCC2(CC1)Cc1ccc(Br)cc1C2=O",
        "output": "140"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.COC(=O)CCSCc1cccc(C(=O)Cl)c1.ClCCl.Nc1ccc(N2CCCCC2)cc1-c1cc(NC(=O)c2cccc(C(F)(F)F)c2)ccn1>>COC(=O)CCSCc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccn2)c1",
        "output": "11"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCCCCOc1cnc(-c2ccc(O)cc2)nc1.FC(F)(COCCCBr)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)F.FC(F)(COCCCCl)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)F>>CCCCCCCCOc1cnc(-c2ccc(OCCCOCC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)F)cc2)nc1",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CCO.Cc1c(-c2nc(N[C@@H]3CCC[C@H](NC(=O)c4ccc(NC(=O)OC(C)(C)C)cc4)C3)ncc2Cl)c2ccccc2n1S(=O)(=O)c1ccccc1.O=C([O-])[O-].[K+].[K+]>>Cc1[nH]c2ccccc2c1-c1nc(N[C@@H]2CCC[C@H](NC(=O)c3ccc(NC(=O)OC(C)(C)C)cc3)C2)ncc1Cl",
        "output": "771"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CCc1c[nH]nc1OCC.CN(C)C=O.COc1ccc(CCl)cc1OCc1nc(-c2ccccc2)oc1C.O.[H-].[Na+]>>CCOC(=O)CCc1cn(Cc2ccc(OC)c(OCc3nc(-c4ccccc4)oc3C)c2)nc1OCC",
        "output": "842"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cccc(NC(=O)[C@H](CO)NS(=O)(=O)c2ccc(Cl)cc2)c1.CS(=O)(=O)Cl>>CCOC(=O)c1cccc(NC(=O)[C@H](COS(C)(=O)=O)NS(=O)(=O)c2ccc(Cl)cc2)c1",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=C(O)c1cc(F)ccc1O.O=S(=O)(O)O>>COC(=O)c1cc(F)ccc1O",
        "output": "33"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.O=C(O)c1cccnc1C(F)(F)F.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1cccnc1C(F)(F)F",
        "output": "293"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(-c2cc(C(F)F)n3ncc(C(=O)O)c3n2)ccc1Cl.Nc1cccc(S(N)(=O)=O)c1>>Cc1cc(-c2cc(C(F)F)n3ncc(C(=O)Nc4cccc(S(N)(=O)=O)c4)c3n2)ccc1Cl",
        "output": "969"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.NO.O.O=C(O)CCOc1cccc(-c2ccccc2)c1.O=S(Cl)Cl.[Na+].[OH-]>>O=C(CCOc1cccc(-c2ccccc2)c1)NO",
        "output": "480"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CN(C)c1ccccn1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O=C1CCCCN1c1ccccc1CCO>>Cc1ccc(S(=O)(=O)OCCc2ccccc2N2CCCCC2=O)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)cc1.Cl.O=C([O-])O.[Fe].[Na+]>>COC(=O)c1ccc(-c2cccc(N)c2)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CO.COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC1CCNCC1.Cl.Cl.ClCCl.ClCCl.O=C(O)CO>>COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC1CCN(C(=O)CO)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Oc1ccc2c(CBr)cc(=O)oc2c1.CO.C[O-].[Na+]>>O=c1cc(CBr)c2ccc(O)cc2o1",
        "output": "22"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCN(C2CCNCC2)C1.O.O=C1c2c(-c3ccccc3)cc(Cl)nc2OCCCN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>O=C1c2c(-c3ccccc3)cc(N3CCC(N4CCCC4)CC3)nc2OCCCN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COc1cccc(C(=O)c2cc(Cl)ccc2N)c1C.O.[BH4-].[Na+]>>COc1cccc(C(O)c2cc(Cl)ccc2N)c1C",
        "output": "157"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=CCNc1cc(Cl)nc(N)n1.COc1ccc(B(O)O)cc1>>C=CCNc1cc(-c2ccc(OC)cc2)nc(N)n1",
        "output": "884"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.Cl.O.O=C(O)c1cc(OC2CCC3(CC2)OCCO3)nc(C(F)(F)F)n1>>O=C1CCC(Oc2cc(C(=O)O)nc(C(F)(F)F)n2)CC1",
        "output": "251"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(O)CCc1ccc(Cl)cc1.O=S(Cl)Cl>>O=C(Cl)CCc1ccc(Cl)cc1",
        "output": "53"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)c1ccc(C(=O)Cl)cc1.CC(C)(N)c1ccc(Br)cc1F.O.O=C([O-])O.[Na+]>>CC(C)(C)c1ccc(C(=O)NC(C)(C)c2ccc(Br)cc2F)cc1",
        "output": "411"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCBr.CN(C)C=O.O.O=C([O-])[O-].Oc1cccc2cc(Br)ccc12.[Cl-].[K+].[K+].[Na+]>>CCCCCCCOc1cccc2cc(Br)ccc12",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCN.CCN(CC)CC.COC(=O)Cl.Cc1cccc2ncc(C(=O)O)c(=O)n12.ClC(Cl)Cl>>CCCNC(=O)c1cnc2cccc(C)n2c1=O",
        "output": "737"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)c1cc(CC(COS(C)(=O)=O)NC(=O)OCc2ccccc2)ccc1OCc1ccccc1.CS(C)=O.O.[C-]#N.[K+]>>CC(C)(C)c1cc(CC(CC#N)NC(=O)OCc2ccccc2)ccc1OCc1ccccc1",
        "output": "705"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc(C(O[C@H]2C[C@H](n3cnc4c(=O)[nH]c(NC(=O)C(C)C)nc43)O[C@@H]2CO[Si](C)(C)C(C)(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1.[F-]>>COc1ccc(C(O[C@H]2C[C@H](n3cnc4c(=O)[nH]c(NC(=O)C(C)C)nc43)O[C@@H]2CO)(c2ccccc2)c2ccc(OC)cc2)cc1",
        "output": "708"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#Cc1cc(C2CC2)c2c(c1)C(C)(C)CC(C)(C)O2.C1CCOC1.CCN(CC)CC.COC(=O)Cc1ccc(I)cc1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>COC(=O)Cc1ccc(C#Cc2cc(C3CC3)c3c(c2)C(C)(C)CC(C)(C)O3)cc1",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)CCc1ccc(B(O)O)cc1.Cc1noc(-c2ccc(Br)cc2)c1NC(C)CCc1cccc(C(F)(F)F)c1>>CCOC(=O)CCc1ccc(-c2ccc(-c3onc(C)c3NC(C)CCc3cccc(C(F)(F)F)c3)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN1CCCC1=O.COC(=O)CN.Cc1c(Br)c2ccccn2c1C(=O)c1ccc(N)c(C(=O)O)c1.Cl.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+].c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>COC(=O)CNC(=O)c1cc(C(=O)c2c(C)c(Br)c3ccccn23)ccc1N",
        "output": "652"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1cc(C(=O)c2cccc(-c3cc4cc(F)ccc4n3S(=O)(=O)c3ccccc3)c2)cc(OC)c1OC.O.[Na+].[OH-]>>COc1cc(C(=O)c2cccc(-c3cc4cc(F)ccc4[nH]3)c2)cc(OC)c1OC",
        "output": "771"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CS(=O)(=O)OCCc1cccnc1.Cc1cccnc1[C@@H]1CCC[C@H](c2ncccc2C)N1>>Cc1cccnc1[C@@H]1CCC[C@H](c2ncccc2C)N1CCc1cccnc1",
        "output": "496"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CI.CN(C)C=O.Cc1noc(C)c1COc1ccc(CC(=O)OCc2ccccc2)cc1C(=O)O.O.O=C([O-])[O-].[Na+].[Na+]>>COC(=O)c1cc(CC(=O)OCc2ccccc2)ccc1OCc1c(C)noc1C",
        "output": "415"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=CBr)c1ccncc1.CN(C)C=O.Cc1ccc2[nH]c3c(c2c1)CN(C)C(C)C3.O=C(O)[C@@H]1CCCN1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>C/C(=C\\n1c2c(c3cc(C)ccc31)CN(C)C(C)C2)c1ccncc1",
        "output": "987"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCCC(CNc2ccccc2)C1.CCC(=O)Cl.CCN(C(C)C)C(C)C.ClCCl>>CCC(=O)N(CC1CCCN(C(=O)OC(C)(C)C)C1)c1ccccc1",
        "output": "160"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1ccc2c(c1)NCC21CCSCC1.CC(=O)Cl.CCN(CC)CC.CN(C)c1ccncc1.Cl.ClCCl>>CC(=O)N1CC2(CCSCC2)c2ccc(Br)cc21",
        "output": "160"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COc1ccccc1B(O)O.Cl[Pd]Cl.O.O=C([O-])O.OCc1cccnc1Cl.[Fe+2].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1ccccc1-c1ncccc1CO",
        "output": "865"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCNCC1.C1CCOC1.Clc1nc(Cl)nc(Cl)n1.O=C([O-])[O-].[Na+].[Na+]>>Clc1nc(Cl)nc(N2CCCCC2)n1",
        "output": "214"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)CCCn2c1nc(C(=O)NCc1ccc(F)cc1-n1cncn1)c(OCc1ccccc1)c2=O.O=C(O)C(F)(F)F>>CC1(C)CCCn2c1nc(C(=O)NCc1ccc(F)cc1-n1cncn1)c(O)c2=O",
        "output": "492"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(COc2cnc(-c3cccc(O)c3)n(C)c2=O)cc1.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>COc1ccc(COc2cnc(-c3cccc(OS(=O)(=O)C(F)(F)F)c3)n(C)c2=O)cc1",
        "output": "731"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)Cl.CC(C)(C)[Si](C)(C)OCCc1csc(CCO)c1.CCN(CC)CC>>CC(=O)OCCc1cc(CCO[Si](C)(C)C(C)(C)C)cs1",
        "output": "126"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.O=C(Cl)N1CCS(=O)(=O)CC1.c1ccc2[nH]c(N3CCCNCC3)nc2c1>>O=C(N1CCCN(c2nc3ccccc3[nH]2)CC1)N1CCS(=O)(=O)CC1",
        "output": "258"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1c[nH]nc1C(F)(F)F.CCOC(C)=O.CN[C@@H]1CCCC[C@H]1NC.Cc1ccccc1.Ic1ccccc1.O=C([O-])[O-].[Cu]I.[K+].[K+]>>CCOC(=O)c1cn(-c2ccccc2)nc1C(F)(F)F",
        "output": "901"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1cc2cc3[nH]c(=O)[nH]c3cc2[nH]1.O>>O=C(O)c1cc2cc3[nH]c(=O)[nH]c3cc2[nH]1",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCBr.CCOC(=O)c1c[nH]c(=O)cc1Nc1ccc(I)cc1F.CN(C)C=O.[H-].[Na+]>>CCCn1cc(C(=O)OCC)c(Nc2ccc(I)cc2F)cc1=O",
        "output": "470"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCI.CN(C)C=O.C[C@H](Cc1ccc(S(=O)(=O)c2c(Cl)cccc2C(=O)O)cc1)NC(=O)C(F)(F)F.O=C([O-])O.O=C([O-])[O-].[K+].[K+].[Na+]>>CCOC(=O)c1cccc(Cl)c1S(=O)(=O)c1ccc(C[C@@H](C)NC(=O)C(F)(F)F)cc1",
        "output": "196"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)c1cc(NCC(=O)C(C)(C)C)n(-c2ccccc2)n1.[Na+].[OH-]>>CC(C)(C)C(=O)CNc1cc(C(=O)O)nn1-c1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.Nc1ccc(CC(=O)NCC2CN(CC(=O)O)CCN(CC(=O)O)CCN2CC(=O)O)cc1.O.S=C(Cl)Cl>>O=C(O)CN1CCN(CC(=O)O)CC(CNC(=O)Cc2ccc(N=C=S)cc2)N(CC(=O)O)CC1",
        "output": "114"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CO.Cl.O=C(O)CCc1c[nH]c2ccccc12>>COC(=O)CCc1c[nH]c2ccccc12",
        "output": "195"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.ClCCl.O.O=C1CC[C@@H](CO)N1.[Cl-].[Na+].c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OC[C@@H]1CCC(=O)N1",
        "output": "193"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CO.NCC(O)CN>>CC(C)(C)OC(=O)NCC(O)CN",
        "output": "631"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CN(c1nc(F)ccc1[N+](=O)[O-])C1CCN(Cc2ccccc2)CC1.O=[Pt].[H][H]>>CN(c1nc(F)ccc1N)C1CCN(Cc2ccccc2)CC1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)C(C)C(=O)NCC(F)(F)F.O.[Li+].[OH-]>>CC(C(=O)O)C(=O)NCC(F)(F)F",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CI.CN(C)C=O.COP(=O)(OC)c1cc(-c2ccc(C)cc2)ccc1O.[Na+].[OH-]>>COc1ccc(-c2ccc(C)cc2)cc1P(=O)(OC)OC",
        "output": "62"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COCCN.ClC(Cl)Cl.F[P-](F)(F)(F)(F)F.O.O=C(O)[C@@H]1CC[C@@H](Oc2cc(-n3c(C(F)F)nc4ccccc43)nc(N3CCOCC3)n2)CC1.[H+]>>COCCNC(=O)[C@@H]1CC[C@@H](Oc2cc(-n3c(C(F)F)nc4ccccc43)nc(N3CCOCC3)n2)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)CCCOc1cnc2c(n1)CCCC2.Cl.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCCOc1cnc2c(n1)CCCC2",
        "output": "225"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1nc2c(Cl)cccc2n1-c1cc(O)ccc1Cl.O=S(=O)(c1cccc(F)c1)C(F)(F)F>>Cc1nc2c(Cl)cccc2n1-c1cc(Oc2cccc(S(=O)(=O)C(F)(F)F)c2)ccc1Cl",
        "output": "564"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.Nc1c(Cl)cc(Br)cc1C(=O)O.[BH4-]>>Nc1c(Cl)cc(Br)cc1CO",
        "output": "72"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.NC(Cc1ccc(C(F)(F)F)o1)C(O)c1ccc(F)cc1.O.O=C(Cl)CCc1ccccc1.O=C([O-])O.[Na+]>>O=C(CCc1ccccc1)NC(Cc1ccc(C(F)(F)F)o1)C(O)c1ccc(F)cc1",
        "output": "45"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[PH+](C(C)(C)C)C(C)(C)C.CN1CCCC1=O.Cc1ccccc1B(O)O.Cc1nc(-c2ccc(C)c(NC(=O)c3cnc4ccc(Br)cn34)c2)no1.F[B-](F)(F)F.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>Cc1nc(-c2ccc(C)c(NC(=O)c3cnc4ccc(-c5ccccc5C)cn34)c2)no1",
        "output": "833"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)c1ccc(C)c(OC)c1[N+](=O)[O-].[H][H].[Pd]>>COC(=O)c1ccc(C)c(OC)c1N",
        "output": "268"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)C(Cc1ccccc1)Oc1ccc2cc(-c3ccc(-c4ccccc4)n3C)ccc2c1.O.[Na+].[OH-]>>Cn1c(-c2ccccc2)ccc1-c1ccc2cc(OC(Cc3ccccc3)C(=O)O)ccc2c1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCNC(=O)c1ccc(NC(c2oc3ccc(OC)cc3c2C#N)C2CCCCC2)cc1.[Na+].[OH-]>>COc1ccc2oc(C(Nc3ccc(C(=O)NCCC(=O)O)cc3)C3CCCCC3)c(C#N)c2c1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1cccc(Br)n1.CC(=O)N(C)C.CCN(C(C)C)C(C)C.CCOC(C)=O.FC(F)(F)c1cc(C(F)(F)F)cc(C2(C(F)(F)F)CCNC2)c1>>FC(F)(F)c1cc(C(F)(F)F)cc(C2(C(F)(F)F)CCN(c3cccc(Br)n3)C2)c1",
        "output": "647"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOC(C)=O.CN(C)C=O.Cn1cc(Br)c(N2CC(CO)CC2=O)n1.c1c[nH]cn1>>Cn1cc(Br)c(N2CC(CO[Si](C)(C)C(C)(C)C)CC2=O)n1",
        "output": "193"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)C2CC[C@@]1(CS(=O)(=O)O)C(=O)C2.CCO.COCOc1ccc2c(c1)OC(C)(C)C(C=O)=C2>>CC1(C)Oc2cc(O)ccc2C=C1C=O",
        "output": "755"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCc1ccc(-c2ccnc(F)c2)nc1.O=C(O)c1ccc(Br)cn1>>O=C(NCc1ccc(-c2ccnc(F)c2)nc1)c1ccc(Br)cn1",
        "output": "137"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)I.CN(C)C=O.COc1ccc(Cl)cc1CN(C)C(=O)CCCSc1ccc(O)cc1.O.[H-].[Na+]>>COc1ccc(Cl)cc1CN(C)C(=O)CCCSc1ccc(OC(C)C)cc1",
        "output": "318"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.COc1ccc(C(CC(=O)O)CC(=O)O)cn1>>COc1ccc(C2CC(=O)OC(=O)C2)cn1",
        "output": "436"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCOc1cc(CCC(=O)OCC)[nH]n1.CN(C)C=O.Fc1ccc(CBr)c(F)c1.O.[H-].[Na+]>>CCCOc1cc(CCC(=O)OCC)n(Cc2ccc(F)cc2F)n1",
        "output": "635"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.CCCCCCCCCCCC(=O)Cl.CCc1ccc2c(c1)C(N1CCN(CCCO)CC1)Cc1ccccc1S2.ClC(Cl)Cl.O=C(O)/C=C\\C(=O)O.[NH4+].[OH-].c1ccccc1>>CCCCCCCCCCCC(=O)OCCCN1CCN(C2Cc3ccccc3Sc3ccc(CC)cc32)CC1",
        "output": "126"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCOP(=O)(CC)CCC#N.NCCCCCCN.O.[H][H].[K+].[Ni].[OH-]>>CCCCOP(=O)(CC)CCCN",
        "output": "246"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCCC(CC(=O)OC)(c1ccc(OC)cc1)c1ccc(OC)cc1.O.[K+].[OH-]>>CCCC(CC(=O)O)(c1ccc(OC)cc1)c1ccc(OC)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.COC(=O)CCOC1CCNCC1.COc1cccc([C@H]2O[C@H](CCC(=O)O)c3cccn3-c3ccc(Cl)cc32)c1OC.Cl.ClCCl.On1nnc2ccccc21>>COC(=O)CCOC1CCN(C(=O)CC[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3-n3cccc32)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(=O)CC1.CCc1cccc(CC)c1-c1cc2cc[nH]c2cn1.CO.O=C([O-])[O-].[Cs+].[Cs+]>>CCc1cccc(CC)c1-c1cc2c(C3=CCN(C(=O)OC(C)(C)C)CC3)c[nH]c2cn1",
        "output": "607"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCOCCCl.Nc1ccc2sccc2c1.[Na+].[OH-]>>c1cc2cc(N3CCOCC3)ccc2s1",
        "output": "640"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O.Clc1nc(Cl)nc(Cl)n1.N#C[C@@H]1C[C@@H]1CO>>N#C[C@@H]1C[C@@H]1COc1nc(Cl)nc(Cl)n1",
        "output": "213"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.Cl.O.O=C(c1ccc(-n2ccnc2Sc2ccccc2[N+](=O)[O-])cc1)N1CCC(N2C(=O)CCc3ccccc32)CC1.[Na+].[OH-]>>Nc1ccccc1Sc1nccn1-c1ccc(C(=O)N2CCC(N3C(=O)CCc4ccccc43)CC2)cc1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)CCCNc1nc(CN2CCN(Cc3ccccc3)CC2)nc2ccccc12.CO.O=C[O-].[NH4+].[Pd]>>CN(C)CCCNc1nc(CN2CCNCC2)nc2ccccc12",
        "output": "84"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClC(Cl)Cl.N.O=C(O)c1ccc(CCC(Br)CBr)cn1.O=S(Cl)Cl>>NC(=O)c1ccc(CCC(Br)CBr)cn1",
        "output": "136"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)CC(N)CC(C)(C)N1.Cc1ccc(N)cc1-c1nc(S(C)(=O)=O)nc2c1ccc(=O)n2-c1c(F)cccc1F>>Cc1ccc(N)cc1-c1nc(NC2CC(C)(C)NC(C)(C)C2)nc2c1ccc(=O)n2-c1c(F)cccc1F",
        "output": "629"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@H](C)N.O=C([O-])O.O=[N+]([O-])c1ccccc1F.[Na+]>>COC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@H](C)Nc1ccccc1[N+](=O)[O-]",
        "output": "572"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCCCOc1ccccc1.ClC(Cl)Cl.O=S(=O)(O)Cl>>O=S(=O)(Cl)c1ccc(OCCCBr)cc1",
        "output": "357"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCNC(=O)C=C1CCCc2sc(C(=O)O)cc21.CCOC(C)=O.CO.O.O=S(=O)(O)O>>CCCCNC(=O)C=C1CCCc2sc(C(=O)OC)cc21",
        "output": "195"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClC(Cl)Cl.O=S(Cl)Cl.OCc1cccc(CCc2ccccc2)c1>>ClCc1cccc(CCc2ccccc2)c1",
        "output": "81"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)OC(C)C.CN(CC(=O)OC(C)(C)C)c1nccc(-c2nc(=O)c3ccccc3s2)n1.O=C(O)C(F)(F)F>>CN(CC(=O)O)c1nccc(-c2nc(=O)c3ccccc3s2)n1",
        "output": "278"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.C[C@@H]1CCCN1CCc1ccc(-c2ccc(CCC(=O)O)cc2)cc1.Cl>>CCOC(=O)CCc1ccc(-c2ccc(CCN3CCC[C@H]3C)cc2)cc1",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClC(Cl)Cl.O=c1nc(Cl)ncn1Cc1ccc(Cl)cc1.OC1CCN(c2ccc(F)cc2)C1>>O=c1nc(OC2CCN(c3ccc(F)cc3)C2)ncn1Cc1ccc(Cl)cc1",
        "output": "213"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)c1cccc2c1OCCO2.COC(=O)c1ccc(OC(=O)N2C[C@H](CN)[C@@H](c3ccccc3)C2)cc1>>COC(=O)c1ccc(OC(=O)N2C[C@H](CNC(C)c3cccc4c3OCCO4)[C@@H](c3ccccc3)C2)cc1",
        "output": "693"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.NCc1ccccc1.O=C(Cl)c1ccccc1>>O=C(NCc1ccccc1)c1ccccc1",
        "output": "411"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.N#Cc1ccc(SC2CCCCC2)cc1.O.O=S([O-])OO.[K+]>>N#Cc1ccc(S(=O)(=O)C2CCCCC2)cc1",
        "output": "730"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCS(=O)(=O)Nc1ccc(Cl)c(NC(=O)Nc2cc(Cl)ncn2)c1F.CN.ClCCCl>>CCCS(=O)(=O)Nc1ccc(Cl)c(NC(=O)Nc2cc(NC)ncn2)c1F",
        "output": "166"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCCCCCCCCCCCCCCCOC[C@H](CC#N)OCCCCCCCCCCCCCCCCCC.CO.Cl.ClCCl.O=C([O-])O.[Na+]>>CCCCCCCCCCCCCCCCCCOC[C@H](CCN)OCCCCCCCCCCCCCCCCCC",
        "output": "246"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)C[C@H]1CCO.CCN(CC)CC.CS(C)=O>>CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)C[C@H]1CC=O",
        "output": "142"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CI.CN(C)C=O.N#Cc1[nH]c(=O)c(F)cc1F.[H-].[Li+]>>Cn1c(C#N)c(F)cc(F)c1=O",
        "output": "191"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)c1ccccc1.ClCCl.O=S(=O)(O)Cl>>CN(C)c1cccc(S(=O)(=O)Cl)c1",
        "output": "182"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCCCCCCCCCO[C@@H]1CCCO[C@H]1COCCCCCCCO.CCN(CC)CC.CS(=O)(=O)Cl.c1ccccc1>>CCCCCCCCCCCCCCCCO[C@@H]1CCCO[C@H]1COCCCCCCCOS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.CN(C)c1ccncc1.O=C1CCc2cc(N3CCC(O)CC3)ccc2N1.c1ccncc1>>CC(=O)OC1CCN(c2ccc3c(c2)CCC(=O)N3)CC1",
        "output": "254"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)Nc1nc2ccc(C)cc2nc1OC.O=[N+]([O-])c1ccc(N2CCNCC2)cc1>>COc1nc2cc(C)ccc2nc1NC(=O)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1",
        "output": "613"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCC.CO.FB(F)F.O=C(O)C(C(=O)O)c1ccccc1>>COC(=O)C(C(=O)O)c1ccccc1",
        "output": "195"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.ClCc1ccccc1CCl.Oc1ccc2oc(-c3ccc4ccc(Cl)cc4n3)cc2c1.[H-].[Na+]>>ClCc1ccccc1COc1ccc2oc(-c3ccc4ccc(Cl)cc4n3)cc2c1",
        "output": "49"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.NCCc1c[nH]c2ccccc12>>CS(=O)(=O)NCCc1c[nH]c2ccccc12",
        "output": "493"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.Cl.O.Oc1c(Br)cc(Br)cc1CBr.[C-]#N.[Na+]>>N#CCc1cc(Br)cc(Br)c1O",
        "output": "39"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.Nc1ccc(F)cc1Br.O=S(Cl)Cl.c1ccncc1>>CC(C)(C)OC(=O)N1CCC(C(=O)Nc2ccc(F)cc2Br)CC1",
        "output": "365"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1=NCCCN2CCCCC12.CC#N.CN(C)NS(=O)(=O)c1ccccc1S(N)(=O)=O.COc1cc(OC)nc(NC(=O)Oc2ccccc2)n1.Cl.O>>COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2ccccc2S(=O)(=O)NN(C)C)n1",
        "output": "690"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O.O=C(O)c1cccc(Br)n1>>CCNC(=O)c1cccc(Br)n1",
        "output": "137"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COc1cc2nccc(Oc3ccc([N+](=O)[O-])cn3)c2cc1OC.O.[Cl-].[Fe].[NH4+]>>COc1cc2nccc(Oc3ccc(N)cn3)c2cc1OC",
        "output": "269"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.COc1cccc(CC(CCC(=O)OC(C)(C)C)NC(C)=O)c1.Cl.[Na+].[OH-]>>COc1cccc(CC(CCC(=O)O)NC(C)=O)c1",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.ClCCl.NC1CC1.O=Cc1cc(Br)cc(Cl)c1Cl.O=S(=O)([O-])[O-].[BH4-].[Mg+2].[Na+]>>Clc1cc(Br)cc(CNC2CC2)c1Cl",
        "output": "468"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](O)[C@H](c2ccccc2)C1.CI.CN(C)C=O.O.[H-].[Na+]>>CO[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@H]1c1ccccc1",
        "output": "140"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.NC1CCC(N2CCCC(N3CCc4cncc5cccc3c45)C2)CC1>>CC(=O)NC1CCC(N2CCCC(N3CCc4cncc5cccc3c45)C2)CC1",
        "output": "339"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)N=C=NC(C)C.CN(C)c1ccncc1.CO.COC(=O)[C@H](CCSC)NC(=O)c1ccc([N+](=O)[O-])cc1-c1ccccc1.C[Si](C)(C)CCO.Cl.[Li+].[OH-]>>CSCC[C@H](NC(=O)c1ccc([N+](=O)[O-])cc1-c1ccccc1)C(=O)OCC[Si](C)(C)C",
        "output": "289"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)c1cccc(-c2ccc(S(=O)(=O)NC3CCCCc4c(OCC(=O)OC(C)(C)C)cccc43)nc2)c1.[Na+].[OH-]>>CC(C)c1cccc(-c2ccc(S(=O)(=O)NC3CCCCc4c(OCC(=O)O)cccc43)nc2)c1",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=C(c1ccc(Nc2ccnc3cc(Cl)ccc23)cc1)N1CCNCC1.O=C=Nc1cccc(Cl)c1>>O=C(Nc1cccc(Cl)c1)N1CCN(C(=O)c2ccc(Nc3ccnc4cc(Cl)ccc34)cc2)CC1",
        "output": "323"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)[O-].O.O=C1CSC(=S)N1.O=Cc1ccc(Oc2ccccc2)cc1.[Na+]>>O=C1NC(=S)SC1=Cc1ccc(Oc2ccccc2)cc1",
        "output": "314"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "FC(F)(F)c1ccc(Br)c(CNCCc2ccccc2)c1.O=C(Cl)C1CC1>>O=C(C1CC1)N(CCc1ccccc1)Cc1cc(C(F)(F)F)ccc1Br",
        "output": "240"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br.CCc1ccc(N)cc1[N+](=O)[O-].O.O=N[O-].[Na+]>>CCc1ccc(Br)cc1[N+](=O)[O-]",
        "output": "373"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=C([O-])O.O=C1CC[C@@H](C(=O)O)N1.O=S(=O)(O)O.O=S(=O)([O-])[O-].[Na+].[Na+].[Na+]>>COC(=O)[C@@H]1CCC(=O)N1",
        "output": "536"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCl.O=C(Cl)c1cccc(C(F)(F)F)c1Cl.c1nc2c(c(-n3cnnc3)n1)CCNC2>>O=C(c1cccc(C(F)(F)F)c1Cl)N1CCc2c(ncnc2-n2cnnc2)C1",
        "output": "201"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN[C@@H]1CCN(Cc2ccccc2)C1.Cc1ccc(C)c2c(C)c(C(=O)O)[nH]c12.N>>Cc1ccc(C)c2c(C)c(C(=O)N(C)[C@@H]3CCN(Cc4ccccc4)C3)[nH]c12",
        "output": "605"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.COc1ccn(-c2ccc(N3CCNCC3)cc2)c(=O)c1.N#Cc1ccc2[nH]cc(CCCCCCl)c2c1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>COc1ccn(-c2ccc(N3CCN(CCCCCc4c[nH]c5ccc(C#N)cc45)CC3)cc2)c(=O)c1",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cccc(CCOc2cccc3[nH]c(C(=O)O)cc23)c1.C[C@H]1CN(CCC2(O)CCC(N)CC2)CC[C@@H]1O>>COc1cccc(CCOc2cccc3[nH]c(C(=O)NC4CCC(O)(CCN5CC[C@H](O)[C@@H](C)C5)CC4)cc23)c1",
        "output": "137"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCBr.CCOC(C)=O.CN(C)C=O.O=[N+]([O-])c1cn[nH]c1.[H-].[Na+]>>CCn1cc([N+](=O)[O-])cn1",
        "output": "577"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCc1nc2ccccc2[nH]1.Cn1c(CN2CC(O)C2)nc2c(N3CCOCC3)nc(Cl)nc21>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CC(O)C3)n(C)c2n1",
        "output": "916"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCC(N2CCNCC2)C1.CCN(C(C)C)C(C)C.CN(C)C=O.O.O=[N+]([O-])c1ccnc(Cl)c1>>O=[N+]([O-])c1ccnc(N2CCN(C3CCCC3)CC2)c1",
        "output": "220"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrC(Br)(Br)Br.OCCCCCC1=C(c2cccc(O)c2)CCCc2cc(O)ccc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Oc1cccc(C2=C(CCCCCBr)c3ccc(O)cc3CCC2)c1",
        "output": "378"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.ClCCl.Nc1ccc(I)cc1.O=C(Cl)c1ccccc1-c1ccc(C(F)(F)F)cc1>>O=C(Nc1ccc(I)cc1)c1ccccc1-c1ccc(C(F)(F)F)cc1",
        "output": "11"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N1CCN(c2ccccc2C#N)CC1.CCO.O=[Pt]>>CC(C)(C)OC(=O)N1CCN(c2ccccc2CN)CC1",
        "output": "175"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COc1c(C#N)cc(C(=O)N2CS(=O)(=O)c3ccccc32)cc1SC.Cl.[Cl-].[Li+]>>CSc1cc(C(=O)N2CS(=O)(=O)c3ccccc32)cc(C#N)c1O",
        "output": "786"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)Oc1cc(OC(C)C)cc(C(=O)O)c1.CCOC(=O)CCSCc1csc(N)n1>>CCOC(=O)CCSCc1csc(NC(=O)c2cc(OC(C)C)cc(OC(C)C)c2)n1",
        "output": "918"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Clc1ccc2nc(N3CCCc4cc(Br)ccc4C3)cc(Cl)c2c1.NCCN>>NCCNc1cc(N2CCCc3cc(Br)ccc3C2)nc2ccc(Cl)cc12",
        "output": "78"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCn1c(CCOC)nc2c(N)nc3cc(OCCCNC(=O)OC(C)(C)C)ccc3c21.CCO.Cl.O.[Na+].[OH-]>>CCCn1c(CCOC)nc2c(N)nc3cc(OCCCN)ccc3c21",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.N#CCBr.N#CCCc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>N#CCCc1ccc(OCC#N)cc1",
        "output": "802"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CS(=O)(=O)c1ccc(OCc2ccccc2)c(C2=C(c3cccc(C(=O)OCc4ccccc4)c3)CCC2)c1.O.[Na+].[OH-]>>CS(=O)(=O)c1ccc(OCc2ccccc2)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1",
        "output": "290"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CCN(CC)CC.ClCCCl.O=C(CCl)N1NCCn2nc(-c3ccc(F)cc3)c(-c3ccncc3)c21>>O=C(CN1CCOCC1)N1NCCn2nc(-c3ccc(F)cc3)c(-c3ccncc3)c21",
        "output": "340"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.O=C(O)c1cc2c(Nc3cc4cn[nH]c4cn3)ncnc2[nH]1>>O=C(c1cc2c(Nc3cc4cn[nH]c4cn3)ncnc2[nH]1)N1CCCCC1",
        "output": "605"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.COc1ccc2[nH]c(=O)cc(CCO)c2c1.ClC(Cl)Cl.O.O=S(Cl)Cl>>COc1ccc2[nH]c(=O)cc(CCCl)c2c1",
        "output": "96"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.O=c1[nH]c(-c2ccccc2C(F)(F)F)cc2ccc(N3CCSCC3)cc12.[Na+]>>O=c1[nH]c(-c2ccccc2C(F)(F)F)cc2ccc(N3CCS(=O)CC3)cc12",
        "output": "13"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.CCOC(C)=O.Cl.Fc1ccc(Br)c(F)c1.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)c1cc(Br)c(F)cc1F",
        "output": "31"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N1CCNCC1.CN1Cc2c(C3CCC(=O)CC3)ccc(N)c2C1=O.CN1Cc2c(C3CCC(N(C)C)CC3)ccc(N)c2C1=O>>CC(=O)N1CCN(C2CCC(c3ccc(N)c4c3CN(C)C4=O)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cc(C(F)(F)F)cc(CN2CCN(C(=O)OC(C)(C)C)CC2)c1N.Nc1c(Br)cc(C(F)(F)F)cc1C(=O)O>>CC(C)(C)OC(=O)N1CCN(Cc2cc(C(F)(F)F)cc(C(=O)O)c2N)CC1",
        "output": "5"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C([O-])[O-].Oc1c(F)cc(Br)cc1F.[Cs+].[Cs+]>>Fc1cc(Br)cc(F)c1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)C(Sc1nc2c(c(-c3ccc(OC)cc3)c1C#N)CCCC2)c1ccccc1.[Na+].[OH-]>>COc1ccc(-c2c(C#N)c(SC(C(=O)O)c3ccccc3)nc3c2CCCC3)cc1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1cccs1.Nc1cccnn1.O=C(O)C1CCN(c2cccs2)CC1>>O=C(Nc1cccnn1)C1CCN(c2cccs2)CC1",
        "output": "795"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)c1cc(C(=O)NC2CCN(C(C)C)CC2)cn1Cc1cc(-c2ccc(Cl)s2)on1.O.O=C(O)C(F)(F)F>>CC(C)N1CCC(NC(=O)c2cc(C(=O)O)n(Cc3cc(-c4ccc(Cl)s4)on3)c2)CC1",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=CBr)c1ccc(C(=O)N(C)C)cc1.CN(C)C=O.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3.O=C(O)[C@@H]1CCCN1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>C/C(=C\\n1c2c(c3cc(C)ccc31)CN(C)CC2)c1ccc(C(=O)N(C)C)cc1",
        "output": "987"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)CN.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.O=C(O)Cn1cc(-c2cccc3nc(Nc4ccc(OCCN5CCCC5)cc4)nn23)cn1.On1nnc2ccccc21>>CC(C)(C)CNC(=O)Cn1cc(-c2cccc3nc(Nc4ccc(OCCN5CCCC5)cc4)nn23)cn1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCO.CCOC(=O)c1ccc(Br)s1.CCOC(C)=O.OB(O)c1ccc(F)cc1.[F-].[K+].[Pd+2]>>CCOC(=O)c1ccc(-c2ccc(F)cc2)s1",
        "output": "864"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccccc1C(C)=O.Cc1cc(C=O)cc(C)c1O>>COc1ccccc1C(=O)C=Cc1cc(C)c(O)c(C)c1",
        "output": "295"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].CCN(CC)CC.CCO.Cl.N#Cc1ccc(S(=O)(=O)C2CCNCC2)cc1.O=C1CCOCC1.[BH3-]C#N.[Na+].[Ti+4]>>N#Cc1ccc(S(=O)(=O)C2CCN(C3CCOCC3)CC2)cc1",
        "output": "187"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C)C=O.Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1.O=C(CCl)Nc1cccc(F)c1.O=C([O-])[O-].[K+].[K+]>>O=C(CN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Nc1cccc(F)c1",
        "output": "340"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1ccc2nccc(-c3ccc(CCN)nc3)c2n1.Cl.ClCCCl.O.O=C1CSc2ccc(C(=O)O)nc2N1.Oc1cccc2[nH]nnc12>>COc1ccc2nccc(-c3ccc(CCNC(=O)c4ccc5c(n4)NC(=O)CS5)nc3)c2n1",
        "output": "137"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1c(-c2csc(C=O)c2)sc2c(N3CCOCC3)nc(Cl)nc12.OC1CCNC1>>Cc1c(-c2csc(CN3CCC(O)C3)c2)sc2c(N3CCOCC3)nc(Cl)nc12",
        "output": "792"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.CO.Cl.Cl.NCCF.O=C1CCC(Nc2cccc3cnccc23)CC1.[Na+]>>FCCNC1CCC(Nc2cccc3cnccc23)CC1",
        "output": "236"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCCC1=O.Cl.N#C[Cu].O=C(O)c1cc(O)cc(Br)c1>>N#Cc1cc(O)cc(C(=O)O)c1",
        "output": "531"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCC(N2CCNCC2)C1.CC(C)(C)OC(=O)N[C@@H]1CC[C@H](n2c(=O)c3cc(F)cnc3n(-c3cccc(-c4ccc(C=O)cc4)c3)c2=O)CC1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@H](n2c(=O)c3cc(F)cnc3n(-c3cccc(-c4ccc(CN5CCN(C6CCCC6)CC5)cc4)c3)c2=O)CC1",
        "output": "567"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CN1CCNCC1.CS(=O)(=O)c1ncc(-c2cc(-c3ccc4c(c3)CCC4=O)c(-c3ccncc3)o2)cn1>>CN1CCN(c2ncc(-c3cc(-c4ccc5c(c4)CCC5=O)c(-c4ccncc4)o3)cn2)CC1",
        "output": "679"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1cccc(Cn2nc(-c3cccc(CCO)c3)ccc2=O)c1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>COC(=O)c1cccc(Cn2nc(-c3cccc(CCOS(=O)(=O)c4ccc(C)cc4)c3)ccc2=O)c1",
        "output": "197"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1ccccc1.O=CO.O=[N+]([O-])c1ccccc1.[O-2].[O-2].[O-2].[O-2].[O-2].[Pt].[V+5].[V+5]>>O=CNc1ccccc1",
        "output": "27"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NCC(N)c1cccc(Cl)c1.COc1cc2[nH]c(=O)c(C(=O)Nc3cc(C(=O)O)ccc3C)cc2cn1>>COc1cc2[nH]c(=O)c(C(=O)Nc3cc(C(=O)NC(CNC(=O)OC(C)(C)C)c4cccc(Cl)c4)ccc3C)cc2cn1",
        "output": "753"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)c1ccc(Br)cc1.CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1.COCCN.Cc1ccccc1.NC(N)=S>>COCCNC(C)c1ccc(Br)cc1",
        "output": "693"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1cccc([N+](=O)[O-])c1O.[Pd]>>COC(=O)c1cccc(N)c1O",
        "output": "481"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)CC1SC2(CCN(C(=O)OC(C)(C)C)CC2)N(CCc2ccccc2)C1=O.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)CC1SC2(CCNCC2)N(CCc2ccccc2)C1=O",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.COc1cccc2cc(C(O)CCCO[Si](C)(C)C(C)(C)C)oc12.[F-]>>COc1cccc2cc(C(O)CCCO)oc12",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)NCC(=O)N1CCC[C@H]1C(=O)O.CCN1CCOCC1.CN(C)C=O.COC(=O)CNC(=O)[C@@H](N)CCC(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)O)cc1>>COC(=O)CNC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)OC(C)(C)C",
        "output": "131"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN.CO.COC(=O)[C@@H](N)Cc1ccc(O)c(C(C)(C)C)c1>>CNC(=O)[C@@H](N)Cc1ccc(O)c(C(C)(C)C)c1",
        "output": "392"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCC(c1ccc2c(c1)NC(=O)C1CCCC21)N(Cc1cccc(Cl)c1)C(=O)OC(C)(C)C.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CCC(c1ccc2c(c1)NC(=S)C1CCCC21)N(Cc1cccc(Cl)c1)C(=O)OC(C)(C)C",
        "output": "695"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1nc(C)cc(=O)[nH]1.O=Cc1ccc(OCCBr)cc1.[H-].[Na+]>>CCc1nc(C)cc(=O)n1CCOc1ccc(C=O)cc1",
        "output": "327"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCS(=O)(=O)n1c2c(c3cc(C(=O)N4CCC(C)CC4)ccc31)CNCC2.CN1CCC(=O)CC1.O=C(O)C(F)(F)F>>CCS(=O)(=O)n1c2c(c3cc(C(=O)N4CCC(C)CC4)ccc31)CN(C1CCN(C)CC1)CC2",
        "output": "187"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.Nc1c(Cl)cc([N+](=O)[O-])cc1Cl.O>>O=[N+]([O-])c1cc(Cl)cc(Cl)c1",
        "output": "324"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Br.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.NC1Cc2ccc(Br)cc2C1>>CC(C)(C)OC(=O)NC1Cc2ccc(Br)cc2C1",
        "output": "631"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCc1cc(CC(N)=O)ccc1OCC1CO1.CCOC(=O)CCN.[Na+].[OH-]>>C=CCc1cc(CC(N)=O)ccc1OCC(O)CNCCC(=O)OCC",
        "output": "16"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.Cl.N#CCCN1CCC(C(c2ccccc2)c2ccccc2)CC1.[Na+].[OH-]>>NCCCN1CCC(C(c2ccccc2)c2ccccc2)CC1",
        "output": "246"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClC(Cl)Cl.OCc1ccncc1O.[Mn+2].[O-2]>>O=Cc1ccncc1O",
        "output": "179"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1csc(-c2cccc(OCc3ccccc3)c2OCc2ccccc2)n1.CO.[Na+].[OH-]>>O=C(O)c1csc(-c2cccc(OCc3ccccc3)c2OCc2ccccc2)n1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CN.CO.COC(=O)CCc1c(-c2ccccc2)n(C)c(=O)c2cc(Cl)ccc12.ClCCl>>CNC(=O)CCc1c(-c2ccccc2)n(C)c(=O)c2cc(Cl)ccc12",
        "output": "392"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C=Cc1ccc(OC(C)=O)cc1.[NH4+].[OH-]>>C=Cc1ccc(O)cc1",
        "output": "22"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CCO.CN(C)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Oc2ccnc(Cl)n2)c1.O=C([O-])[O-].[Na+].[Na+]>>CN(C)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Oc2ccnc(N3CCOCC3)n2)c1",
        "output": "36"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.Cc1ccc(S(=O)(=O)O)cc1.Cl.O.O=C(Cl)OCc1ccccc1.O=C(O)C1(c2ccccc2)CCNCC1.[Na+].[OH-]>>O=C(OCc1ccccc1)N1CCC(C(=O)O)(c2ccccc2)CC1",
        "output": "427"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.COCC(=O)O.ClCCl.NCCc1ccccc1>>COCC(=O)NCCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCOC(=O)c1cc2c(-c3cc(OCc4ccccc4)c(Cl)cc3Cl)nc(N)nc2s1.CO.ClB(Cl)Cl.ClCCl.O=C=O>>CCOC(=O)c1cc2c(-c3cc(O)c(Cl)cc3Cl)nc(N)nc2s1",
        "output": "23"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N(Cc1ccc2c(Cl)cn(CCN)c2c1)C1CC1.COC(=O)Cl.ClC(Cl)Cl.O.c1ccncc1>>COC(=O)NCCn1cc(Cl)c2ccc(CN(C(=O)OC(C)(C)C)C3CC3)cc21",
        "output": "94"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cl.O=C(O)C1(c2cccnc2)CCNCC1>>CC(C)(C)OC(=O)N1CCC(C(=O)O)(c2cccnc2)CC1",
        "output": "694"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)O.CCCCO.Fc1ccc(N2CCNCC2)cc1.O=C([O-])[O-].OC(CCCl)COc1ccccc1.[Na+].[Na+]>>OC(CCN1CCN(c2ccc(F)cc2)CC1)COc1ccccc1",
        "output": "138"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1nc2sccn2c1C(=O)NC[C@H]1NC[C@H]2C[C@H]21.O=S(=O)(Cl)c1cccc2ccccc12>>Cc1nc2sccn2c1C(=O)NC[C@@H]1[C@@H]2C[C@@H]2CN1S(=O)(=O)c1cccc2ccccc12",
        "output": "99"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)CC1.CCOC(=O)N=NC(=O)OCC.Cc1cc([N+](=O)[O-])ccc1O.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc([N+](=O)[O-])ccc1OC1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "846"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)C(=O)Cl.Nc1cc(Cl)ccc1Cl.O.c1ccncc1>>CC(C)(C)C(=O)Nc1cc(Cl)ccc1Cl",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1cc2c(Br)nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c2cc1[N+](=O)[O-].ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>O=[N+]([O-])c1cc2c(cc1CBr)c(Br)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "29"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cl.ClCCl.N[C@@H]1C[C@H]1c1ccccc1.O.O=Cc1ccc(C(F)(F)F)cc1.[Na+]>>FC(F)(F)c1ccc(CN[C@@H]2C[C@H]2c2ccccc2)cc1",
        "output": "468"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.O=C(Nc1nc(CC(=O)N2CCNCC2)cs1)c1ccc(Cl)cc1.O=C(O)CBr>>O=C(Nc1nc(CC(=O)N2CCN(C(=O)CBr)CC2)cs1)c1ccc(Cl)cc1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)[O-].CC(C)N1C(=O)C(C)(C)c2ccc(Br)cc21.ClC(Cl)Cl.NCc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Na+].[Na+].[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)N1C(=O)C(C)(C)c2ccc(NCc3ccccc3)cc21",
        "output": "932"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCc1c(OC)cc(C(=O)OC)cc1OC.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCc1c(OC)cc(CO)cc1OC",
        "output": "444"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(N2CCN[C@@H](Cc3ccccc3)C2)cc1OC(F)F.O=C(O)Cc1ccccn1>>COc1ccc(N2CCN(C(=O)Cc3ccccn3)[C@@H](Cc3ccccc3)C2)cc1OC(F)F",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC(C)=O.CC(C)c1cccc(C(C)C)c1N.O.O.O.O.O=C(Br)CBr.[Na+]>>CC(C)c1cccc(C(C)C)c1NC(=O)CBr",
        "output": "442"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCP1(=O)CCN(C(=O)Cc2ccc(C(=O)OC(C)(C)C)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>CCP1(=O)CCN(C(=O)Cc2ccc(C(=O)O)cc2)CC1",
        "output": "752"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)C(=O)OC[C@@H]1CSC(c2cc3cccc([N+](=O)[O-])c3[nH]2)=N1.CO.O.[Cl-].[Fe].[NH4+]>>CC(C)(C)C(=O)OC[C@@H]1CSC(c2cc3cccc(N)c3[nH]2)=N1",
        "output": "269"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCOC(=O)c1cc(OCC)c2c(c1)C(=O)c1cccc(OCC)c1C2=O.O.[K+].[OH-]>>CCOc1cccc2c1C(=O)c1c(OCC)cc(C(=O)O)cc1C2=O",
        "output": "5"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1noc2cc3c(cc12)CCN(C(=O)C(F)(F)F)CC3.CO.O=C([O-])[O-].[Na+].[Na+]>>CCc1noc2cc3c(cc12)CCNCC3",
        "output": "703"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1CCN(C[C@@H]2CCCN2)CC1.O=C1Nc2ccc(S(=O)(=O)Cl)cc2C1=O>>CN1CCN(C[C@@H]2CCCN2S(=O)(=O)c2ccc3c(c2)C(=O)C(=O)N3)CC1",
        "output": "99"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CS(C)=O.C[C@@H](O)CN.Cc1nc(F)ccc1Br>>Cc1nc(NC[C@@H](C)O)ccc1Br",
        "output": "810"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1c(C)nc2ccc(Cl)nn12.COCCOC.Cl[Pd]Cl.O=C([O-])[O-].OB(O)c1ccccc1O.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)c1c(C)nc2ccc(-c3ccccc3O)nn12",
        "output": "866"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2)cc1.O.O=[N+]([O-])O>>CCc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2[N+](=O)[O-])cc1",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cc1c(F)cc(-c2cccc(F)c2)cc1[N+](=O)[O-].[Pd]>>Cc1c(N)cc(-c2cccc(F)c2)cc1F",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCCCBr.CCOc1cccc(Cc2ncc(C=O)c3cc(O)c(OC)cc23)c1.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOc1cccc(Cc2ncc(C=O)c3cc(OCCCBr)c(OC)cc23)c1",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)c1coc2ccc(-c3nnc(C)o3)cc12>>Cc1nnc(-c2ccc3occ(C(=O)O)c3c2)o1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.Cl.O=[N+]([O-])c1cc(-c2ccccc2)ccc1Cl.[Sn]>>Nc1cc(-c2ccccc2)ccc1Cl",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(OCC)P(=O)(CC(C[N+](=O)[O-])c1ccccc1)OCC.N.[H][H].[Ni]>>CCOC(OCC)P(=O)(CC(CN)c1ccccc1)OCC",
        "output": "226"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccccc1C(=O)O.NCC(c1ccc(Cl)cc1)N1CCC(F)(F)CC1>>Cc1ccccc1C(=O)NCC(c1ccc(Cl)cc1)N1CCC(F)(F)CC1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCOC(C)=O.Cc1c(C)c(OCc2ccccc2)c(CCCCO)c(C)c1OCc1ccccc1.ClCCl.O=C([O-])O.[Na+]>>Cc1c(C)c(OCc2ccccc2)c(CCCC=O)c(C)c1OCc1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1ccc(F)c(CO)c1.O=C(O)c1ccc(Br)cn1>>O=C(Nc1ccc(F)c(CO)c1)c1ccc(Br)cn1",
        "output": "548"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C.O.[Li+].[OH-]>>CC(C)(C)OC(=O)NS(=O)(=O)c1ccccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.CN=C=O.Cl.FC(F)(F)c1cc(CO[C@H]2CCNC[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1.O>>CNC(=O)N1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](C(c2ccccc2)c2ccccc2)C1",
        "output": "437"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1[C@@H]1C[C@H](CO)C1.Cc1ccc(S(=O)(=O)Cl)cc1.OC[C@H]1CCCN1>>CCc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1[C@@H]1C[C@H](CN2CCC[C@@H]2CO)C1",
        "output": "371"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)c1nc(N[C@H]2CCC[C@H](N)C2)nc2ccccc12.CO.Cl.O.O=Cc1ccc(C(F)(F)F)nc1.[BH4-].[Na+].[Na+].[OH-]>>CN(C)c1nc(N[C@H]2CCC[C@H](NCc3ccc(C(F)(F)F)nc3)C2)nc2ccccc12",
        "output": "441"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN[C@H]1CCNC1.CCO.FC(F)(F)c1ccc2c(Cl)nc(Cl)nc2c1>>CCN[C@H]1CCN(c2nc(Cl)nc3cc(C(F)(F)F)ccc23)C1",
        "output": "296"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCC(=O)c1ccccc1.CO.Cc1ccccc1C.[K+].[OH-]>>CCCCC(O)c1ccccc1",
        "output": "24"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1ccc2cnn(CCN3CCCC3)c2c1.O=C(O)CCSc1ccc2ccccc2c1>>O=C(CCSc1ccc2ccccc2c1)Nc1ccc2cnn(CCN3CCCC3)c2c1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F.Cc1ccccc1.NCC1CCCCN1.O>>O=C(NCC1CCCCN1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F",
        "output": "338"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@@H](CCO)C(=O)O.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N[C@@H](CCO)C(=O)O",
        "output": "626"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.Nc1ccc(C(=O)NNCCC(=O)O)cc1.OCc1ccccc1>>Nc1ccc(C(=O)NNCCC(=O)OCc2ccccc2)cc1",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=S(=O)(O)O.O=[N+]([O-])O.Oc1ncccc1C(F)(F)F>>O=[N+]([O-])c1cnc(O)c(C(F)(F)F)c1",
        "output": "328"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1nc2c(C)cc(Br)cc2c(Cl)c1Cc1ccc(-n2cccn2)cc1.Cn1cncc1C(=O)c1ccc([N+](=O)[O-])cc1.O=C(c1ccc(Cl)cc1)c1ccc([N+](=O)[O-])cc1>>Nc1ccc(C(=O)c2ccc(Cl)cc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cl.Cl.N[C@H](CC1CCCCC1)C(=O)O.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)[C@H](N)CC1CCCCC1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(O)c2[nH]c(-c3ccc(F)c(Cl)c3)nc12.O.O.[Li]O>>O=C(O)c1ccc(O)c2[nH]c(-c3ccc(F)c(Cl)c3)nc12",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COCn1c2c(c3cc(Cl)ccc31)CCC(C(C)(C(=O)OC)S(=O)(=O)c1ccccc1)C2.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COCn1c2c(c3cc(Cl)ccc31)CCC(C(C)(CO)S(=O)(=O)c1ccccc1)C2",
        "output": "343"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCI.Cc1cc(=O)n(-c2ccccc2)[nH]1>>CCCn1c(C)cc(=O)n1-c1ccccc1",
        "output": "346"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CN.O=c1ccc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)nn1Cc1ccc(Cl)nc1>>CNc1ccc(Cn2nc(-c3nc(-c4ccc(OC(F)(F)F)cc4)no3)ccc2=O)cn1",
        "output": "70"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCC2=NCCCN2CC1.COc1nc2cc(Br)ccc2c(=O)[nH]1.ClCCl.O=P(Cl)(Cl)Cl>>COc1nc(Cl)c2ccc(Br)cc2n1",
        "output": "14"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)c1cc(C2CC2)c(CN2CCC(Oc3cc(Cl)cc(Cl)c3)CC2)cc1F.CC(C)(C)OC(=O)c1cc(C2CC2)c(CN2CCC[C@H](Oc3cc(Cl)cc(Cl)c3)C2)cc1F>>O=C(O)c1cc(C2CC2)c(CN2CCC(Oc3cc(Cl)cc(Cl)c3)CC2)cc1F",
        "output": "752"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CO.Cc1ccc(F)cc1-n1nc(CN(C)C(=O)OC(C)(C)C)cc1S(=O)(=O)c1ccc(Cl)nc1>>Cc1ccc(F)cc1-n1nc(CN(C)C(=O)OC(C)(C)C)cc1S(=O)(=O)c1cccnc1",
        "output": "40"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)CC(O)CC(C)(C)C1.CN(C)C=O.O=[N+]([O-])c1ccc(F)cc1.[H-].[Na+]>>CC1(C)CC(Oc2ccc([N+](=O)[O-])cc2)CC(C)(C)C1",
        "output": "485"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1cccc(C(O)C2CCNCC2)c1OC.Fc1ccc(CCBr)cc1.O=C([O-])[O-].[K+].[K+]>>COc1cccc(C(O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CCN(C)Cc1cc(C)nc(OC)c1CN.C=CCc1c(C(=O)O)cccc1N(CC)C1CCOCC1.CN(C)C=O.CN1CCOCC1.ClCCCl.On1nnc2cccnc21>>C=CCc1c(C(=O)NCc2c(CN(C)CC=C)cc(C)nc2OC)cccc1N(CC)C1CCOCC1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.COc1ccc(N)cc1N1CCN(C)CC1.Cc1ccccc1.O=C(O)c1ccc(-n2cncn2)cc1.O=S(Cl)Cl>>COc1ccc(NC(=O)c2ccc(-n3cncn3)cc2)cc1N1CCN(C)CC1",
        "output": "817"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cc([N+](=O)[O-])c(Sc2cccc(Cl)c2Cl)s1.O.[K+].[OH-]>>O=C(O)c1cc([N+](=O)[O-])c(Sc2cccc(Cl)c2Cl)s1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CI.CN(C)C=O.Cc1ccc(C)n1-c1cc(C(C)(C)O)n(C)n1.O.[H-].[Na+]>>COC(C)(C)c1cc(-n2c(C)ccc2C)nn1C",
        "output": "140"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC#CCn1c(N2CCCC(NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(CC(=O)OC)c(=O)n2C.CO.[K+].[OH-]>>CC#CCn1c(N2CCCC(NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(CC(=O)O)c(=O)n2C",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)c1nc(-c2ccc3c(c2)N(C(=O)OC(C)(C)C)CCC3)ccc1OS(=O)(=O)C(F)(F)F.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1nc(-c2ccc3c(c2)NCCC3)ccc1OS(=O)(=O)C(F)(F)F",
        "output": "830"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(CCOCc1ccccc1)Oc1ccccc1.[OH-].[OH-].[Pd+2]>>CC(C)(CCO)Oc1ccccc1",
        "output": "178"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(C)=O.COC(=O)COc1ccc(C(=O)Nc2ccc(F)cc2)cn1.O=S(=O)(O)O>>CCOC(=O)COc1ccc(C(=O)Nc2ccc(F)cc2)cn1",
        "output": "289"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCc1csc(C2(O)CCOCC2)n1.CCCCCC.CCOC(C)=O.CI.[H-].[Na+]>>COC1(c2nc(CO[Si](C)(C)C(C)(C)C)cs2)CCOCC1",
        "output": "140"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.C[C@@H](c1ccc(Br)cc1)N1CC[C@](CCC(=O)O)(c2ccc(F)cc2)CC1=O.ClCCl.N.On1nnc2ccccc21>>C[C@@H](c1ccc(Br)cc1)N1CC[C@](CCC(N)=O)(c2ccc(F)cc2)CC1=O",
        "output": "313"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.ClCCl.NC1CCCCC1.O.O=C(Cl)C(=O)Cl.O=C(O)c1cnn(-c2ccc(Br)cc2)c1C1CC1>>O=C(NC1CCCCC1)c1cnn(-c2ccc(Br)cc2)c1C1CC1",
        "output": "621"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)CC1CCc2cc(NC(=O)Cc3ccc4nc(Nc5ccccc5C)oc4c3)ccc21.[Na+].[OH-]>>Cc1ccccc1Nc1nc2ccc(CC(=O)Nc3ccc4c(c3)CCC4CC(=O)O)cc2o1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=O.CC(=O)O.Cc1cc(C(C)OCC2(c3ccc(F)cc3)CCN(C(=O)OC(C)(C)C)CC2)c2c(cnn2CC2CC2)c1.O=C(O)C(F)(F)F.[BH3-]C#N.[Na+]>>Cc1cc(C(C)OCC2(c3ccc(F)cc3)CCN(C)CC2)c2c(cnn2CC2CC2)c1",
        "output": "881"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1cc(C#N)cc(C)c1O.OCC(C1CCC(F)(F)CC1)n1c(-c2ccc(Cl)cc2)nc2cc(F)c(F)cc21>>Cc1cc(C#N)cc(C)c1OCC(C1CCC(F)(F)CC1)n1c(-c2ccc(Cl)cc2)nc2cc(F)c(F)cc21",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cnn(-c2nc3cc(Sc4cccc(C)c4)c(Cl)cc3[nH]2)c1.O.O.[Li]O>>Cc1cccc(Sc2cc3nc(-n4cc(C(=O)O)cn4)[nH]c3cc2Cl)c1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)C1(NC(=O)c2cccc(C)c2C2=CCCC2)Cc2ccc(F)cc2C1.O.[K+].[OH-]>>Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(F)cc3C2)c1C1=CCCC1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCCCCC.CO.COc1cc(N2CCC(N3CCCCC3)CC2)ccc1N.COc1ccc(-c2nc3cc(F)ccn3c2-c2ccnc(Cl)n2)cc1C(=O)Nc1c(F)cccc1F.C[O-].ClCCl.OCC(F)(F)F.[Na+]>>COc1cc(N2CCC(N3CCCCC3)CC2)ccc1Nc1nccc(-c2c(-c3ccc(OC)c(C(=O)Nc4c(F)cccc4F)c3)nc3cc(F)ccn23)n1",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCN(CC)CC.CCOC(=O)Cc1ccc(N)c(C)c1.Cc1ccc(OCc2cccc(Cl)c2)cc1C(=O)Cl.ClCCl>>CCOC(=O)Cc1ccc(NC(=O)c2cc(OCc3cccc(Cl)c3)ccc2C)c(C)c1",
        "output": "11"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.CNCc1cccs1.ClCCl.O=C(O)C12CC3CC(CC(O)(C3)C1)C2>>CN(Cc1cccs1)C(=O)C12CC3CC(CC(O)(C3)C1)C2",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Cl)n2)cc1)OCC.CCOc1cc(CP(=O)(OCC)OCC)ccc1N.FC(F)(F)c1cnc(Cl)nc1Cl>>CCOc1cc(CP(=O)(OCC)OCC)ccc1Nc1ncc(C(F)(F)F)c(Cl)n1",
        "output": "808"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOCc1nc2cnc3ccc(OCc4ccccc4)cc3c2n1CC(C)(C)NC(=O)OC(C)(C)C.Cl>>CCOCc1nc2cnc3ccc(OCc4ccccc4)cc3c2n1CC(C)(C)N",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.C[C@H]1COCc2nc3c(N)nc4ccc(O)cc4c3n21.Cl.ClC(Cl)Cl.ClCCN1CCOCC1.O.O=C([O-])[O-].[Br-].[Cs+].[Cs+]>>C[C@H]1COCc2nc3c(N)nc4ccc(OCCN5CCOCC5)cc4c3n21",
        "output": "74"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrBr.CC(C)(C)c1ccc(O)c(C(C)(C)C)c1>>CC(C)(C)c1cc(Br)c(O)c(C(C)(C)C)c1",
        "output": "98"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1cn(CCN2Cc3ccccc3C2=O)nn1.[Na+].[OH-]>>O=C(O)c1cn(CCN2Cc3ccccc3C2=O)nn1",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCC1CC(N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)OCc2ccccc2)C(=O)O1.CO.[Pd]>>CCCCCCC1CC(N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)O)C(=O)O1",
        "output": "186"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N1CCNCC1.CCN(CC)CC.O.O=[N+]([O-])c1cc(F)c(Cl)cc1NC1CC1>>CC(=O)N1CCN(c2cc(NC3CC3)c([N+](=O)[O-])cc2F)CC1",
        "output": "105"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)N1CC2(CCN(Cc3ccccc3)CC2)OC1=O.CCO.[Pd]>>CC(C)(C)N1CC2(CCNCC2)OC1=O",
        "output": "84"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1.Cl.NC1(c2ncccn2)C=CC(C2CCCCC2)(S(N)(=O)=O)C(=O)C1.Nc1ccn(C2CCCCC2)c(=O)n1.O.c1ccncc1>>CC(=O)Nc1ccc(S(=O)(=O)Nc2ccn(C3CCCCC3)c(=O)n2)cc1",
        "output": "462"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.C[C@H](O)CNC[C@H](CCc1c(F)cncc1NC(=O)[C@@H](N=[N+]=[N-])[C@@H](c1ccc(F)cc1)c1cc(F)cc(F)c1)NS(=O)(=O)C1CC1.ClCCl.O>>C[C@H](O)CN(C[C@H](CCc1c(F)cncc1NC(=O)[C@@H](N=[N+]=[N-])[C@@H](c1ccc(F)cc1)c1cc(F)cc(F)c1)NS(=O)(=O)C1CC1)C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CCOc1cc(CO)cc(C#N)c1-c1ccc(F)cc1.CS(C)=O.O>>CCOc1cc(C=O)cc(C#N)c1-c1ccc(F)cc1",
        "output": "179"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C(O)CNC(=O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(F)cc2Cl)cc1.OC1CCNCC1>>O=C(NCC(=O)N1CCC(O)CC1)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(F)cc2Cl)cc1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CNc1cc(Cl)nc(Cl)n1.N[C@@H]1CC[C@H](C(=O)NCc2ccccc2C(F)(F)F)CC1.O.O=C([O-])C(F)(F)F.[Na+].[OH-]>>CNc1cc(Cl)nc(N[C@@H]2CC[C@H](C(=O)NCc3ccccc3C(F)(F)F)CC2)n1",
        "output": "544"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)N(C)C.CC(C)(C)[O-].CCOC(C)=O.NCc1cccc(OC(F)(F)F)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=c1[nH]nc(Cl)c2cc(Br)ccc12.O=c1[nH]nc(Cl)c2ccc(Br)cc12.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>O=c1[nH]nc(Cl)c2ccc(NCc3cccc(OC(F)(F)F)c3)cc12",
        "output": "932"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.O.O=C(O)c1ccccc1>>COC(=O)c1ccccc1",
        "output": "33"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN1C(=O)CC[C@@H]1CO.CS(=O)(=O)Cl.ClCCl.O>>CN1C(=O)CC[C@@H]1COS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)c1cnc(Oc2ccc(C(C)C(O)(c3ccc(=O)n(C)c3)C(F)(F)F)c(Cl)c2Cl)cn1.Cl.[Na+].[OH-]>>CC(c1ccc(Oc2cnc(C(=O)O)cn2)c(Cl)c1Cl)C(O)(c1ccc(=O)n(C)c1)C(F)(F)F",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O=[N+]([O-])c1cnn(CC2CC2)c1.[Pd]>>Nc1cnn(CC2CC2)c1",
        "output": "628"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1ccc(CO)cc1.CSc1nc(Cl)cc(Cl)n1.O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(COc2cc(Cl)nc(SC)n2)cc1",
        "output": "653"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=Cc1cccc(F)c1.OCCO>>Fc1cccc(C2OCCO2)c1",
        "output": "117"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)/C=C/c1cc(OC)c(Cl)cc1N.Cl.[Na+].[OH-]>>COc1cc(/C=C/C(=O)O)c(N)cc1Cl",
        "output": "122"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NC(=O)c1cc(-c2cccnc2[C@@H](N)Cc2cc(F)cc(F)c2)ccc1F.O=C(O)C(F)(F)F.O=C(O)Cn1nc(C(F)(F)F)cc1C1=CCCC1>>NC(=O)c1cc(-c2cccnc2[C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)(F)F)cc2C2=CCCC2)ccc1F",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)c1ccc(CN)cc1.CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.Cl.O=C(O)c1cc(-c2ccc(OCc3ccccc3)cc2)c(=O)n2ccc3ccsc3c12.On1nnc2ccccc21>>CCN(CC)c1ccc(CNC(=O)c2cc(-c3ccc(OCc4ccccc4)cc3)c(=O)n3ccc4ccsc4c23)cc1",
        "output": "790"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCN(CC)CC.CCOC(C)=O.C[Si](C)(C)C#N.ClCCl.ClCCl.O=C(Cl)c1ccccc1.[O-][n+]1cccc(-c2csc(C3(c4ccccc4)CC3)n2)c1>>N#Cc1ccc(-c2csc(C3(c4ccccc4)CC3)n2)cn1",
        "output": "720"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)OB(c2ccc(N)cc2)OC1(C)C.Fc1cc(Br)ccc1C(F)(F)F>>Nc1ccc(-c2ccc(C(F)(F)F)c(F)c2)cc1",
        "output": "933"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1cc2cc([N+](=O)[O-])ccc2n1CCN1CCCC1.[Pd]>>Cc1cc2cc(N)ccc2n1CCN1CCCC1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=O.CC#N.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCN[C@@H](CO)C1.CO.ClCCl.O.O=C([O-])[O-].[Na+].[Na+].[Na+]>>CN1CCN(C(=O)OC(C)(C)C)C[C@@H]1CO",
        "output": "217"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)CCN.O=C(O)c1cccc2nc3ccc4c(OCc5ccccc5)cccc4c3nc12>>CN(C)CCNC(=O)c1cccc2nc3ccc4c(OCc5ccccc5)cccc4c3nc12",
        "output": "674"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(C)(C)CCS3)nc1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC1(C)CCSc2ccc(C#Cc3ccc(CO)cn3)cc21",
        "output": "383"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cc1cc(OC2CCSCC2)cc(C)c1Br.O.O=S([O-])OO.[K+]>>Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1Br",
        "output": "847"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrBr.CC(=O)O.Nc1ccc(-c2cccnc2)cc1[N+](=O)[O-]>>Nc1c(Br)cc(-c2cccnc2)cc1[N+](=O)[O-]",
        "output": "98"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC.CN1CCNCC1.COCCOC.COc1cc2c(Nc3ccc4cn[nH]c4c3)c(C#N)cnc2cc1OCCCl.[I-].[Na+]>>COc1cc2c(Nc3ccc4cn[nH]c4c3)c(C#N)cnc2cc1OCCN1CCN(C)CC1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Clc1ccc(N[C@H]2CCNC2)nn1.F[P-](F)(F)(F)(F)F.O=Cc1ccc(F)c(C(=O)O)c1>>O=Cc1ccc(F)c(C(=O)N2CC[C@H](Nc3ccc(Cl)nn3)C2)c1",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)c1cccc(C=O)c1.CCN(C(C)C)C(C)C.CS(C)=O.Cl.ClCCCl.ClCCl.Cn1cc(-c2nc3c(-c4ccc(CN)c(F)c4)ccnc3[nH]2)cn1.[Na+]>>Cn1cc(-c2nc3c(-c4ccc(CNCc5cccc(C(C)(C)C)c5)c(F)c4)ccnc3[nH]2)cn1",
        "output": "683"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)N=C=O.Cl.ClCCl.NCc1nc2c(C(F)(F)F)cc(C(F)(F)F)cc2[nH]1>>CC(C)(C)NC(=O)NCc1nc2c(C(F)(F)F)cc(C(F)(F)F)cc2[nH]1",
        "output": "244"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cccc(C(C)C)c1B(O)O.O.O=[N+]([O-])O>>Cc1c([N+](=O)[O-])ccc(C(C)C)c1B(O)O",
        "output": "21"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1C[C@@H]2CNCCN2C1.CC(=O)N(C)C.CC1CCCO1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)c1cc(S(=O)(=O)Nc2ccccc2F)c(F)cc1Cl>>O=C(c1cc(S(=O)(=O)Nc2ccccc2F)c(F)cc1Cl)N1CCN2CCC[C@@H]2C1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)C[C@@H](C(=O)N[C@H]1CC[C@@H]2CN(c3ccccc3C(F)(F)F)C[C@H]12)N(C)C(=O)OC(C)(C)C.Cl>>CN[C@@H](CC(C)C)C(=O)N[C@H]1CC[C@@H]2CN(c3ccccc3C(F)(F)F)C[C@H]12",
        "output": "634"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrC(Br)(Br)Br.C=CC(CCO)c1ccccc1.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C=CC(CCBr)c1ccccc1",
        "output": "378"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=O.CC(=O)O.CO.COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CC2CNCC2C1.ClCCl.O>>COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CC2CN(C)CC2C1",
        "output": "217"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCBr.CCO.CCOc1cnc(-c2ccc(O)cc2)nc1.[K+].[OH-]>>CCCCCCCCOc1ccc(-c2ncc(OCC)cn2)cc1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COc1ccc2c(c1)n(C)c(=O)n2CCC(C)(C)[N+](=O)[O-].Cl[Sn]Cl>>COc1ccc2c(c1)n(C)c(=O)n2CCC(C)(C)N",
        "output": "226"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=Cc1ccc(C(C)C)cc1)CBr.CN(C)C=O.Cc1ccc(O)cc1.O.[H-].[Na+]>>CC(=Cc1ccc(C(C)C)cc1)COc1ccc(C)cc1",
        "output": "77"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCOC(Cc1ccc(OCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C)C(=O)OC.[Li+].[OH-]>>CCCCOC(Cc1ccc(OCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)c1ccncc1.Cl.Cl.ClCCl.NS(=O)(=O)N1CCC1.O=C(O)c1cc(Cl)c(OCC2(C(F)(F)F)CCCC2)cc1F>>O=C(NS(=O)(=O)N1CCC1)c1cc(Cl)c(OCC2(C(F)(F)F)CCCC2)cc1F",
        "output": "886"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.C[O-].Cl.O=[N+]([O-])c1ccc(F)cc1O.[Na+]>>COc1ccc([N+](=O)[O-])c(O)c1",
        "output": "485"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H](N)C1.CS(C)=O.O=C1NCCc2[nH]c(-c3cccc4ccc(Cl)nc34)cc21>>CC(C)(C)OC(=O)N1CCC[C@H](Nc2ccc3cccc(-c4cc5c([nH]4)CCNC5=O)c3n2)C1",
        "output": "70"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.O.O=C(O)C1CC2CCN1CC2.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OCC1CC2CCN1CC2",
        "output": "218"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CCc1cnn2c1NCCC2.Cl.[Na+].[OH-]>>O=C(O)CCc1cnn2c1NCCC2",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.CO.C[Si](C)(C)C=[N+]=[N-].Cc1cc2cc(C(=O)O)ccc2n1Cc1ccc(Cl)cc1.[Au]>>COC(=O)c1ccc2c(c1)cc(C)n2Cc1ccc(Cl)cc1",
        "output": "195"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)c1cc(-c2nc(C(=O)N3CCCC(F)(F)C3)co2)ccc1CNC(=O)C(F)(F)c1cccs1.O.[Li+].[OH-]>>O=C(O)c1cc(-c2nc(C(=O)N3CCCC(F)(F)C3)co2)ccc1CNC(=O)C(F)(F)c1cccs1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CS(=O)(=O)c1ccc(C(CC2CCC(=O)C2)C(=O)O)cc1Cl.ClCCl.Nc1cnc(Br)cn1.O=C(Cl)C(=O)Cl.c1ccncc1>>CS(=O)(=O)c1ccc(C(CC2CCC(=O)C2)C(=O)Nc2cnc(Br)cn2)cc1Cl",
        "output": "692"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN1CCNCC1.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)COc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3ccccc3n2)c1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CN1CCN(C(=O)COc2cccc(-c3nc(Nc4ccc5[nH]ncc5c4)c4ccccc4n3)c2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCCCCCCBr.CN(C)C=O.COC(=O)c1ccc2cccc(O)c2n1.ClCCl.[H-].[I-].[Na+].[Na+]>>CCCCCCCCCCCCOc1cccc2ccc(C(=O)OC)nc12",
        "output": "608"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1.Cl.[Na+].[OH-]>>O=C(O)c1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1cc(Cl)ccc1C(N)c1ccccc1.Cc1ncccc1Cc1cc2cc(CC(=O)O)ccc2o1.ClCCCl.On1nnc2ccccc21>>Cc1cc(Cl)ccc1C(NC(=O)Cc1ccc2oc(Cc3cccnc3C)cc2c1)c1ccccc1",
        "output": "769"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)CCNC(=O)c1ccc(C(C)Oc2ccc(-c3ccc(C(F)(F)F)cc3)cc2)s1.Cl.[Na+].[OH-]>>CC(Oc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)c1ccc(C(=O)NCCC(=O)O)s1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(CC2NC(=O)n3c2nc2cc(F)ccc23)cc1F.COc1ccc(CC2NC(=O)n3c2nc2ccc(F)cc23)cc1F.Cl.NC12CCC(O)(CC1)CC2>>COc1ccc(CC(NC(=O)NC23CCC(O)(CC2)CC3)c2nc3ccc(F)cc3[nH]2)cc1F",
        "output": "999"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)NCCN.O=C([O-])O.O=C1CCCCC1.[Na+].[Na+]>>CC(C)(C)OC(=O)NCCNC1CCCCC1",
        "output": "236"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "NCCO.O=c1[nH]cnc2cc(F)ccc12>>NCCOc1ccc2c(=O)[nH]cnc2c1",
        "output": "636"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCc1cc(OC(C)C)nn1C(C)c1ccc(Cl)cc1Cl.Cc1ccccc1.[Cl-].[NH4+]>>CC(C)Oc1cc(CCCO)n(C(C)c2ccc(Cl)cc2Cl)n1",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCCl.FC(F)(F)c1c(Cl)cc(Oc2cccc(Oc3cc(Cl)c(C(F)(F)F)c(Cl)c3)c2)cc1Cl.O=S(=O)(O)O.O=[N+]([O-])O>>O=[N+]([O-])c1ccc(Oc2cc(Cl)c(C(F)(F)F)c(Cl)c2)cc1Oc1cc(Cl)c(C(F)(F)F)c(Cl)c1",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.COc1cc2c(cc1Br)CCC2=O.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COc1cc2c(cc1N1CCOCC1)CCC2=O",
        "output": "294"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCc1cc(-c2ccc(Cl)cc2)cc(CC)c1Br.COB(OC)OC.Cl.[Li]C(C)(C)C>>CCc1cc(-c2ccc(Cl)cc2)cc(CC)c1B(O)O",
        "output": "789"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CCl.CO>>N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CCl",
        "output": "538"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.O=C(Cc1ccc(-n2cnnn2)cc1)N1CCC(O)(C#Cc2ccc3nonc3c2)CC1.[Pd]>>O=C(Cc1ccc(-n2cnnn2)cc1)N1CCC(O)(CCc2ccc3nonc3c2)CC1",
        "output": "717"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccccc1.C=CCCn1c2c(c(=O)c(O)c1C(C)C=C)C(=O)N(Cc1ccc(F)cc1)CC2.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].[Cs+].[Cs+]>>C=CCCn1c2c(c(=O)c(OCc3ccccc3)c1C(C)C=C)C(=O)N(Cc1ccc(F)cc1)CC2",
        "output": "623"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)Cc1cc([N+](=O)[O-])ccc1F.ClCCl.[H][H].[Pd]>>COC(=O)Cc1cc(N)ccc1F",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.Clc1nc(Cl)c2ccccc2n1.NCC(c1ccccc1)c1ccccc1>>Clc1nc(NCC(c2ccccc2)c2ccccc2)c2ccccc2n1",
        "output": "110"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.Cc1ccc(Oc2ccc(Nc3ncnc4ccc(-c5csc(CNC(=O)OC(C)(C)C)n5)cc34)cc2C)cn1.Cl.O.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(Oc2ccc(Nc3ncnc4ccc(-c5csc(CN)n5)cc34)cc2C)cn1",
        "output": "538"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.N#Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1-n1cccn1.O.O=C1CCC(=O)N1Cl>>N#Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1-n1cc(Cl)cn1",
        "output": "856"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.FC(F)(F)c1ccncc1.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1ccc(C(F)(F)F)cc1",
        "output": "262"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COc1cccc(C(=O)O)c1.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[Li+].[Na+]>>COc1cccc(CO)c1",
        "output": "72"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.CS(=O)(=O)Nc1ccc(-c2nc(NCC(c3ccccc3)c3ccccn3)c3ccccc3n2)cc1.Cc1cc(NS(C)(=O)=O)ccc1B(O)O.ClC(Cl)Cl.Clc1nc(NCC(c2ccncc2)c2ccncc2)c2ccccc2n1>>Cc1cc(NS(C)(=O)=O)ccc1-c1nc(NCC(c2ccncc2)c2ccncc2)c2ccccc2n1",
        "output": "874"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCSc1cc(Br)ccc1-c1nc2cc(C(F)(F)F)cnc2n1C.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>CCS(=O)c1cc(Br)ccc1-c1nc2cc(C(F)(F)F)cnc2n1C",
        "output": "500"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1cccc(-c2ccc(C=O)cc2)c1.O=C1CSC(=O)N1>>CCOC(=O)c1cccc(-c2ccc(C=C3SC(=O)NC3=O)cc2)c1",
        "output": "761"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.CO.O=C(O)Cc1cccc(O)c1>>COC(=O)Cc1cccc(O)c1",
        "output": "195"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.O=C(COc1cccc(Cl)c1)NC1CCNCC1.O=Cc1ccc(-c2ccccn2)cc1.[Na+]>>O=C(COc1cccc(Cl)c1)NC1CCN(Cc2ccc(-c3ccccn3)cc2)CC1",
        "output": "567"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNCCO.ClCCl.O>>CN(CCO)C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC1(CO)COC1.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>CCC1(COS(=O)(=O)c2ccc(C)cc2)COC1",
        "output": "197"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=O.CC(C)(C)OC(=O)N1CCCC1c1ccc(CCn2ccc(OCc3ccc(F)cc3)cc2=O)cc1.CC(C)=O.O=c1cc(OCc2ccc(Cl)cn2)ccn1CCc1ccc(C2CCCN2)cc1>>CN1CCCC1c1ccc(CCn2ccc(OCc3ccc(Cl)cn3)cc2=O)cc1",
        "output": "69"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.COC(=O)c1nc(-c2ccc3c(c2)NCCC3)ccc1O>>COC(=O)c1nc(-c2ccc3c(c2)N(C(=O)OC(C)(C)C)CCC3)ccc1O",
        "output": "827"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)Oc1cc(Nc2nc(Cl)ccc2[N+](=O)[O-])n[nH]1.CCCCO.CCN(C(C)C)C(C)C.CCOC(C)=O.Cl.N[C@@H](CO)c1ccc(F)cn1>>CC(C)Oc1cc(Nc2nc(N[C@@H](CO)c3ccc(F)cn3)ccc2[N+](=O)[O-])n[nH]1",
        "output": "70"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)CN(CC(F)(F)F)c1ccc(C#N)c(C(F)(F)F)c1.CC[SiH](CC)CC.ClCCl.O=C(O)C(F)(F)F>>N#Cc1ccc(N(CC(=O)O)CC(F)(F)F)cc1C(F)(F)F",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CCN1CCc2[nH]c(C=O)c(C)c2C1=O.O=C1Cc2c(cccc2-c2ccc(Cl)cc2F)N1>>CCN(CC)CCN1CCc2[nH]c(C=C3C(=O)Nc4cccc(-c5ccc(Cl)cc5F)c43)c(C)c2C1=O",
        "output": "440"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "NC[C@@H]1[C@H]2C[C@H]2CN1C(=O)c1nc(N)sc1-c1cccc(F)c1.O=C(O)c1c[nH]c2ccccc12>>Nc1nc(C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2c[nH]c3ccccc23)c(-c2cccc(F)c2)s1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.CNCCO.CS(=O)(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1CC(=O)O>>CN(CCO)C(=O)CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1S(C)(=O)=O",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=Cc1ccc(Br)cc1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)NC1CCNCC1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1ccccc1.[Pd+2]>>C=Cc1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)cc1",
        "output": "294"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COc1ccccc1Br.Cn1ccc2c(C=O)cccc21.[Mg]>>COc1ccccc1C(O)c1cccc2c1ccn2C",
        "output": "379"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CCc1ccc(B(O)O)cc1.Cc1noc(-c2ccc(Br)cc2)c1C(O)c1cn(Cc2ccccc2)nn1>>CCOC(=O)CCc1ccc(-c2ccc(-c3onc(C)c3C(O)c3cn(Cc4ccccc4)nn3)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cc(N2CCC(=O)CC2)ccc1[N+](=O)[O-].F[C@@H]1CCNC1>>COc1cc(N2CCC(N3CC[C@@H](F)C3)CC2)ccc1[N+](=O)[O-]",
        "output": "187"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCCC2CN(Cc3ccccc3)CC21.CO.Cl.Cl.Nc1c(F)c(N)c(F)c(F)c1F.[Pd]>>CN1CCCC2CNCC21",
        "output": "84"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1ccc2c(c1)[nH]c1c(C(N)=O)cc(-c3cccc(OC)c3)cc12.CO.[Na+].[OH-]>>COc1cccc(-c2cc(C(N)=O)c3[nH]c4cc(C(=O)O)ccc4c3c2)c1",
        "output": "5"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cn(C2CC2)c2c(OC(F)F)c(-c3cc4n(c3)CCN(C)C4)ccc2c1=O.Cl>>CN1CCn2cc(-c3ccc4c(=O)c(C(=O)O)cn(C5CC5)c4c3OC(F)F)cc2C1",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCCBr.CN(C)C=O.Cc1c2c(=O)[nH]c3cc4c(cc3c2nn1C(=O)OC(C)(C)C)CCCC4.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1c2c(=O)n(CCCNC(=O)OC(C)(C)C)c3cc4c(cc3c2nn1C(=O)OC(C)(C)C)CCCC4",
        "output": "470"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)CC1N=C(c2ccccc2)c2cc(OC)c(OC)cc2N(CC)C1=O.CO.N>>CCN1C(=O)C(CC(N)=O)N=C(c2ccccc2)c2cc(OC)c(OC)cc21",
        "output": "163"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccccc1.C1COCCO1.ClCCl.O=C([O-])[O-].O=C1NCC[C@@H]1O.[Cs+].[Cs+]>>O=C1[C@@H](O)CCN1c1ccccc1",
        "output": "809"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(C)=O.CNC(=O)COc1ccc(O)cc1.Fc1ccccc1CBr.O=C([O-])[O-].[K+].[K+]>>CNC(=O)COc1ccc(OCc2ccccc2F)cc1",
        "output": "127"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.C=Cc1ccc(B(O)O)cc1.CC(C)(C)P.Clc1cccc(-c2cccnc2)c1.F[K].O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Pd]>>C=Cc1ccc(-c2cccc(-c3cccnc3)c2)cc1",
        "output": "892"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.NC1CN(CC(=O)OC(c2ccccc2)c2ccccc2)C1=O.O.O=C(Cl)COc1ccccc1>>O=C(COc1ccccc1)NC1CN(CC(=O)OC(c2ccccc2)c2ccccc2)C1=O",
        "output": "159"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C(O)c1c(-c2ccccc2)c2ccccc2[nH]c1=O>>O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2[nH]c1=O",
        "output": "790"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2[nH]c(=O)[nH]c2c1.c1ccc2c(c1)C[C@@H]1NCCC[C@H]21>>O=C(c1ccc2[nH]c(=O)[nH]c2c1)N1CCC[C@@H]2c3ccccc3C[C@@H]21",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#CCCC.C1CCOC1.CCN(CC)CC.CCOCC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Fc1cc(Br)ccc1I.O.[Cu]I>>CCCC#Cc1ccc(Br)cc1F",
        "output": "664"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.O=C(C1CC1)N1CCC(CNc2ccncc2[N+](=O)[O-])C1.[Pd]>>Nc1cnccc1NCC1CCN(C(=O)C2CC2)C1",
        "output": "269"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.CCN(C(C)C)C(C)C.COc1cc(OC2CCNCC2)ccc1C(=O)N1CCC(N2C(=O)CCc3ccccc32)CC1.ClCCl>>COc1cc(OC2CCN(C(C)=O)CC2)ccc1C(=O)N1CCC(N2C(=O)CCc3ccccc32)CC1",
        "output": "369"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNC1.CCN(CC)CC.O=C(Cl)CCCl.c1ccccc1>>O=C(CCCl)N1CCCC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccccc1C.Cl.ClCCNCCCl.N#Cc1cccc(N)c1.[Na+].[OH-]>>N#Cc1cccc(N2CCNCC2)c1",
        "output": "640"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNC1.O=C(O)Cc1ccc(S(=O)(=O)Cl)cc1>>O=C(O)Cc1ccc(S(=O)(=O)N2CCCC2)cc1",
        "output": "99"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N1CC2CC(NCc3ccccc3)CC2C1.CO.[OH-].[OH-].[Pd+2]>>CC(C)(C)OC(=O)N1CC2CC(N)CC2C1",
        "output": "561"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1nc(Cl)c(-c2ccccc2)c(NC2CCCC2)n1.NC1CCCC1>>CCc1nc(NC2CCCC2)c(-c2ccccc2)c(NC2CCCC2)n1",
        "output": "110"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=CBr)c1ccc(Cl)cc1.CN(C)C=O.CN1CCc2c([nH]c3ccc(Cl)cc23)C1.O=C(O)[C@@H]1CCCN1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>CC(=Cn1c2c(c3cc(Cl)ccc31)CCN(C)C2)c1ccc(Cl)cc1",
        "output": "987"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN1CCN(c2nc(-c3ccc(OCCOCc4ccccc4)cc3OC)cc3ccccc23)CC1.CO.Cl.[Pd]>>CCN1CCN(c2nc(-c3ccc(OCCO)cc3OC)cc3ccccc23)CC1",
        "output": "178"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.[H][H].[N-]=[N+]=NCc1cc(C(N)=O)cc(C(N)=O)c1.[Pd]>>NCc1cc(C(N)=O)cc(C(N)=O)c1",
        "output": "562"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1CN(C(=O)C(F)(F)F)CCc2nc(O)c(I)cc21.CN(C)C=O.O=P(Cl)(Cl)Cl>>CC1CN(C(=O)C(F)(F)F)CCc2nc(Cl)c(I)cc21",
        "output": "41"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(C(C)C)C(C)C.CO.CS(=O)(=O)c1ccc2nc(-c3ccc(C(F)(F)F)cc3)c(CN3CCC(N4CCOCC4)CC3)c(C(=O)O)c2c1.CS(C)=O.ClCCl.N[C@H](c1ccccc1)C(F)(F)F.O>>CS(=O)(=O)c1ccc2nc(-c3ccc(C(F)(F)F)cc3)c(CN3CCC(N4CCOCC4)CC3)c(C(=O)N[C@H](c3ccccc3)C(F)(F)F)c2c1",
        "output": "753"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)OC[C@H](C)N(C(=O)Nc1ccc(OC)cc1)C2.NO.[Na+].[OH-]>>COc1ccc(NC(=O)N2Cc3ccc(C(=O)NO)cc3OC[C@@H]2C)cc1",
        "output": "988"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.c1ccc2c(c1)CCCN2>>CC(C)(C)OC(=O)N1CCCc2ccccc21",
        "output": "827"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COC(=O)c1cc(OCCC2(CCO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)CCCCC2)cc(C(=O)OC)c1.O=C(O)CC(O)(CC(=O)O)C(=O)O.[F-]>>COC(=O)c1cc(OCCC2(CCO)CCCCC2)cc(C(=O)OC)c1",
        "output": "781"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCNC.COc1nc2[nH]ncc2cc1Nc1ncnc2sc3c(c12)CC[C@H](C(=O)O)C3>>CCN(C)C(=O)[C@H]1CCc2c(sc3ncnc(Nc4cc5cn[nH]c5nc4OC)c23)C1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1cccc([C@@H]2CNC(=O)N2C2CCNCC2)c1.Cc1nc(Oc2ccc(OCC(=O)OC(C)(C)C)cc2)ccc1C=O.ClCCl.[Na+]>>Cc1cccc([C@@H]2CNC(=O)N2C2CCN(Cc3ccc(Oc4ccc(OCC(=O)OC(C)(C)C)cc4)nc3C)CC2)c1",
        "output": "757"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)c1nc(CN)cs1.O=C(O)c1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1>>CC(C)c1nc(CNC(=O)c2cnc(OCC(F)(F)F)c(-c3ccc(Cl)cc3)c2)cs1",
        "output": "674"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O.CCOC(C)=O.CI.CN(C)C=O>>COC(=O)[C@H](Cc1c[nH]c2ccc(O)cc12)NC(=O)OC(C)(C)C",
        "output": "415"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(N)cc1Br.Clc1ccccn1>>Cc1ccc(Nc2ccccn2)cc1Br",
        "output": "434"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CN(C)C=O.COC(=O)C(=O)c1ccc(O)cc1.CS(=O)(=O)[O-].OCCCCc1ccncc1.[H-].[Na+]>>COC(=O)C(=O)c1ccc(OCCCCc2ccncc2)cc1",
        "output": "478"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCS(=O)(=O)N1CCC(c2cn(COCC[Si](C)(C)C)c3c(C#N)cc(Br)cc23)CC1.CN(C)CC(=O)O.Cl.O.O=C([O-])[O-].Oc1ccc(F)cc1.[Cs+].[Cs+].[Cu]I>>CCS(=O)(=O)N1CCC(c2cn(COCC[Si](C)(C)C)c3c(C#N)cc(Oc4ccc(F)cc4)cc23)CC1",
        "output": "238"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CO.O=[N+]([O-])c1cccc2c1ccn2S(=O)(=O)c1cccc2ccccc12.[H][H].[Pd]>>Nc1cccc2c1ccn2S(=O)(=O)c1cccc2ccccc12",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(O)CCCC1(C)C(OCc2ccccc2)CCCC12OCCO2.CCOCC.ClCCl.[Cr+6].[O-2].[O-2].[O-2].c1ccncc1>>CC(=O)CCCC1(C)C(OCc2ccccc2)CCCC12OCCO2",
        "output": "87"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1cccc(-c2c(Cc3ccccc3)cnc3c(C(F)(F)F)cccc23)c1.O=Cc1cccc(C(F)(F)F)c1F>>Fc1c(CNc2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)cccc1C(F)(F)F",
        "output": "359"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CO.Cc1ccc([N+](=O)[O-])cc1N.Clc1cc(Cl)ncn1.O=C([O-])O.[Na+]>>Cc1ccc([N+](=O)[O-])cc1Nc1cc(Cl)ncn1",
        "output": "161"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.Cc1noc(-c2sc(N)nc2-c2ccccc2)n1>>CC(=O)Nc1nc(-c2ccccc2)c(-c2nc(C)no2)s1",
        "output": "553"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)Cl.ClCCl.Fc1cnc(-c2c[nH]c3ncc(Cl)cc23)nc1NC[C@@H]1CCCNC1.c1ccncc1>>CS(=O)(=O)N1CCC[C@@H](CNc2nc(-c3c[nH]c4ncc(Cl)cc34)ncc2F)C1",
        "output": "584"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(-c2nc3cc(C(=O)Cl)ccc3o2)cc1.ClC(Cl)Cl.O.O=C(c1ccccc1)c1ccc(O)cc1O.[Na+].[OH-]>>Cc1ccc(-c2nc3cc(C(=O)Oc4ccc(C(=O)c5ccccc5)c(O)c4)ccc3o2)cc1",
        "output": "482"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.CC(C)(C)[O-].CC(C)C1=CC(C(C)C)=C(c2ccccc2)C(C(C)C)(P(C2CCCCC2)C2CCCCC2)C1.Cc1c(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)nc2cc(F)ccc2c1N1CC(C)(C)c2ccc(I)cc21.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1c(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)nc2cc(F)ccc2c1N1CC(C)(C)c2ccc(N3CCOCC3)cc21",
        "output": "931"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncn3)cc(S(C)(=O)=O)c2)c1CCC(=O)OCC.[Na+].[OH-]>>CS(=O)(=O)c1cc(OCCCCCCc2cccc(OCCCC(=O)O)c2CCC(=O)O)cc(-c2ccncn2)c1",
        "output": "255"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.O.O.O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)C(Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)c1ccc2c(c1)OCO2>>O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)C(Cc1c[nH]cn1)c1ccc2c(c1)OCO2",
        "output": "838"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC.COc1ccc(-c2c(C)nn(COCC[Si](C)(C)C)c2-c2cnc(N)nc2)cc1.ClB(Cl)Cl.ClCCl.O=C([O-])O.[Na+]>>COc1ccc(-c2c(C)n[nH]c2-c2cnc(N)nc2)cc1",
        "output": "813"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C1CCNCC1.O=CCCNC(=O)c1cc([N+](=O)[O-])c(Sc2c(Cl)cncc2Cl)s1>>CN(C)C1CCN(CCCNC(=O)c2cc([N+](=O)[O-])c(Sc3c(Cl)cncc3Cl)s2)CC1",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1ccc2c(c1)c(NC1CCNCC1)cc(=O)n2C.ClCCl.ClCc1ccc2c(c1)OCO2>>COc1ccc2c(c1)c(NC1CCN(Cc3ccc4c(c3)OCO4)CC1)cc(=O)n2C",
        "output": "156"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C[C@@H]1CN(c2ccc3nnc(C(F)(F)F)n3n2)CCN1.O=Cc1ccncc1>>C[C@@H]1CN(c2ccc3nnc(C(F)(F)F)n3n2)CCN1Cc1ccncc1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1sc2ncnc(Nc3cccnc3OC3CCOCC3)c2c1C.Cl.ClCCl.[Na+].[OH-]>>Cc1c(C(=O)O)sc2ncnc(Nc3cccnc3OC3CCOCC3)c12",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cn(CCO)c2nc(N3CCN(C)CC3)ncc2c1=O.ClC(Cl)Cl.O=S(Cl)Cl>>CCOC(=O)c1cn(CCCl)c2nc(N3CCN(C)CC3)ncc2c1=O",
        "output": "96"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#Cc1cc(C(=O)OC(C)(C)C)c2c(c1)C(C)(C)CC(C)(C)O2.CCCCCC.CCN(CC)CC.CCOC(C)=O.COC(=O)Cc1ccc(I)cc1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>COC(=O)Cc1ccc(C#Cc2cc(C(=O)OC(C)(C)C)c3c(c2)C(C)(C)CC(C)(C)O3)cc1",
        "output": "664"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CC2CCC1CNC2.CC(C)(C)C(C)(C)Nc1nc(Cl)nc(NC(C)(C)C(C)(C)C)n1.COCCOCCOC>>CC(C)(C)C(C)(C)Nc1nc(NC(C)(C)C(C)(C)C)nc(N2CC3CCC(CC3)C2)n1",
        "output": "214"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCCCCCc1cc2ccc(C(=O)O)cc2[nH]1.CO.Cl>>CCCCCCCCCCCc1cc2ccc(C(=O)OC)cc2[nH]1",
        "output": "195"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.Cl[Pd]Cl.O.O=C(C1CC1)N1CC[C@@H](Cc2n[nH]c(=O)n2-c2ccc(Br)cc2F)C1.O=C(O)c1ccc(B(O)O)cc1.O=C([O-])[O-].[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=C(O)c1ccc(-c2ccc(-n3c(C[C@@H]4CCN(C(=O)C5CC5)C4)n[nH]c3=O)c(F)c2)cc1",
        "output": "837"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1c(N)cc(Cl)n1-c1ccc(CC)cc1.ClCCl.O=C(Cl)Cc1ccccc1.c1ccncc1>>CCOC(=O)c1c(NC(=O)Cc2ccccc2)cc(Cl)n1-c1ccc(CC)cc1",
        "output": "422"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(Cl)cc1Oc1ccc(S(C)(=O)=O)cc1Cl.[Na+].[OH-]>>CS(=O)(=O)c1ccc(Oc2cc(Cl)ccc2C(=O)O)c(Cl)c1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.COc1ccc(-c2cc(Cl)nnc2-c2ccc(OC)cc2)cc1>>COc1ccc(-c2cc(N3CCOCC3)nnc2-c2ccc(OC)cc2)cc1",
        "output": "406"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Nc1ccc2c(c1)CCC2.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>CC(=O)Nc1cc2c(cc1[N+](=O)[O-])CCC2",
        "output": "21"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C=CCCCOc1cc(C(=O)NCC(OC)OC)cc(C(=O)OC)c1.Cl.ClCCl>>C=CCCCOc1cc(C(=O)NCC=O)cc(C(=O)OC)c1",
        "output": "234"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1cc2cc(S(F)(F)(F)(F)F)ccc2s1.O.O.[Li+].[OH-]>>O=C(O)c1cc2cc(S(F)(F)(F)(F)F)ccc2s1",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCC.CCOC(C)=O.CS(C)=O.Cc1ccccc1O.O=Cc1ccc(F)cc1.[H-].[Na+]>>Cc1ccccc1Oc1ccc(C=O)cc1",
        "output": "564"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(NCCCCNC(=O)OC(C)(C)C)c1nccs1.Cc1cccnc1C=O.ClCCl.[Na+]>>Cc1cccnc1CN(CCCCNC(=O)OC(C)(C)C)C(C)c1nccs1",
        "output": "829"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COc1cc(CCN)ccc1OCc1ccccc1.[H][H].[Pd]>>COc1cc(CCN)ccc1O",
        "output": "23"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)Cl.C[C@H](N)CO.O.O=C([O-])O.[Na+]>>COC(=O)N[C@@H](C)CO",
        "output": "94"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)O.Cc1cc(Cl)nc(Nc2ccccc2)n1.[H-].[Na+]>>Cc1cc(OC(C)C)nc(Nc2ccccc2)n1",
        "output": "653"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)NCCCl.CN(C)C=O.O=C([O-])[O-].O=C(c1ccccc1)c1ccc(O)cc1.[K+].[K+]>>CCOC(=O)NCCOc1ccc(C(=O)c2ccccc2)cc1",
        "output": "74"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)O.CCCCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)OCC)cn2)c1.CO.O.[Na+].[OH-]>>CCCCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)O)cn2)c1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCC(C(=O)c2cccc(N)c2)CC1.O=C(Cl)c1ccc(Br)cc1>>CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(Br)cc3)c2)CC1",
        "output": "11"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNCCC(c1ccccc1)c1cccc2cn[nH]c12.ClCCl.O=C(O)C(F)(F)F>>CN(CCC(c1ccccc1)c1cccc2cn[nH]c12)C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.NN.O=C(O)CCCCC(O)c1ccc(-c2ccc(Cl)cc2)cc1>>NNC(=O)CCCCC(O)c1ccc(-c2ccc(Cl)cc2)cc1",
        "output": "459"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN1C(CN)CCC1c1ccccc1.COc1cc(N)c(Cl)cc1C(=O)O>>CCN1C(CNC(=O)c2cc(Cl)c(N)cc2OC)CCC1c1ccccc1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CNC(=O)Nc1ccc(C2=NN(C(=O)Cc3cc(OC)c(OC)cc3Br)CC2)cc1.CO.O=P([O-])([O-])[O-].OB(O)c1ccccc1.[K+].[K+].[K+]>>CNC(=O)Nc1ccc(C2=NN(C(=O)Cc3cc(OC)c(OC)cc3-c3ccccc3)CC2)cc1",
        "output": "837"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CCOc1cccc(N(C)C)c1C=O.COc1cc2nc(NCCN(C)C)nc(NC3CCNCC3)c2cc1OC>>CCN(CC)CCOc1cccc(N(C)C)c1CN1CCC(Nc2nc(NCCN(C)C)nc3cc(OC)c(OC)cc23)CC1",
        "output": "567"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Nc1ccc(C(C)=O)cc1[N+](=O)[O-].O.O=S(=O)(O)O>>CC(=O)c1ccc(N)c([N+](=O)[O-])c1",
        "output": "66"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Nc1cc(C(=O)O)ccc1F.O=S(Cl)Cl>>COC(=O)c1ccc(F)c(N)c1",
        "output": "33"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.Clc1cc(Nc2ccc3cccnc3c2)ncn1.FC(F)(F)C1CCNCC1.O=C([O-])[O-].[K+].[K+]>>FC(F)(F)C1CCN(c2cc(Nc3ccc4cccnc4c3)ncn2)CC1",
        "output": "162"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.O=C(O)CCc1ccc([N+](=O)[O-])cn1.[Pd]>>Nc1ccc(CCC(=O)O)nc1",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)n1c(-c2cccc(N)c2)cc2ccccc21.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1cc2cccc(O)c2oc1=O>>CC(C)(C)OC(=O)n1c(-c2cccc(NC(=O)c3cc4cccc(O)c4oc3=O)c2)cc2ccccc21",
        "output": "799"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1ccc(N)cc1.CCCC=O>>CCCCNc1ccc(C(C)(C)C)cc1",
        "output": "336"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.O.O=C(Cl)OCc1ccccc1.O=C(O)C1CCCNC1.[Na+].[OH-]>>O=C(O)C1CCCN(C(=O)OCc2ccccc2)C1",
        "output": "427"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1ccc2cncn2c1Nc1ccc(C2CC2)cc1F.[Na+].[OH-]>>O=C(O)c1ccc2cncn2c1Nc1ccc(C2CC2)cc1F",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.C1COCCO1.CCN(CC)CC.Clc1nn2c(-c3ccccc3)nnc2cc1C1CCC1>>c1ccc(-c2nnc3cc(C4CCC4)c(N4CCOCC4)nn23)cc1",
        "output": "406"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC/C=C\\CCO.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC/C=C\\CCOS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.O=C([O-])[O-].O=S1(=O)NC(N2CCNCC2)=Nc2ccc(Cl)cc21.[Na+].[Na+]>>CN1CCN(C2=Nc3ccc(Cl)cc3S(=O)(=O)N2)CC1",
        "output": "483"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CNC1.CCCCOc1nc(N)c2nc(OC)n(CCCCCl)c2n1.CCN(C(C)C)C(C)C.CN(C)C=O>>CCCCOc1nc(N)c2nc(OC)n(CCCCN3CCC3)c2n1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1c(C)nc2cccc(OC[C@@H](N)C(C)C)c2c1N.O=C(O)c1cccc2c1OCCO2>>CCOC(=O)c1c(C)nc2cccc(OC[C@@H](NC(=O)c3cccc4c3OCCO4)C(C)C)c2c1N",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.O=C(NC1CCN(C(=O)OCc2ccccc2)CC1O)c1ccccn1>>O=C(NC1CCN(C(=O)OCc2ccccc2)CC1=O)c1ccccn1",
        "output": "650"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCCS(=O)(=O)Nc1ccc(F)c(C(=O)OCc2ccccc2)c1Cl.Cl.O.O=C([O-])O.[Ba+2].[Na+].[OH-].[OH-]>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)O)c1Cl",
        "output": "290"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CN)c3Cl)c2n1.Cl.O.O=C(O)CCCc1ccccc1.On1nnc2ccccc21>>Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CCCc4ccccc4)c3Cl)c2n1",
        "output": "133"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.CCOC(=O)c1ccc(Cl)nc1C.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>CCOC(=O)c1ccc(Cl)nc1CBr",
        "output": "590"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)NC(=O)c1ccc(CNc2c(Cl)ccc3c2CCN(C(=O)OC(C)(C)C)CC3)cc1F>>CC(C)NC(=O)c1ccc(CNc2c(Cl)ccc3c2CCNCC3)cc1F",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1cccc(CO)n1.CO.Cl.[Na+].[OH-]>>O=C(O)c1cccc(CO)n1",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)/C=C/c1ccc(O)cc1.CS(C)=O.FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CCCI.[Na+].[OH-]>>COC(=O)/C=C/c1ccc(OCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc1",
        "output": "198"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1cccc(NC(=O)c2ccc(N3CCN(c4ccc(C(=O)O)cc4)CC3)c(F)c2)c1.CC(C)(C)c1cccc(NC(=O)c2ccc(N3CCNCC3)c(Cl)c2)c1.O=C(O)c1ccc(Br)cc1>>CC(C)(C)c1cccc(NC(=O)c2ccc(N3CCN(c4ccc(C(=O)O)cc4)CC3)c(Cl)c2)c1",
        "output": "294"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.Cl.Clc1cccc(N2CCNCC2)c1.O=C(NCC(F)(F)F)C1(CCCCBr)c2ccccc2-c2ccccc21>>O=C(NCC(F)(F)F)C1(CCCCN2CCN(c3cccc(Cl)c3)CC2)c2ccccc2-c2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCN1.CC(C)(O)Cn1cnc2c(N)nc3cc(CCC(=O)O)ccc3c21.CCN=C=NCCCN(C)C.CN(C)C=O.On1nnc2ccccc21>>CC(C)(O)Cn1cnc2c(N)nc3cc(CCC(=O)N4CCOCC4)ccc3c21",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(=O)c1ncn2c1COc1c(CC=O)cccc1-2.Cc1ccc2c(N3CCN[C@H](C)C3)cc(F)cc2n1.ClCCCl.[Na+]>>CCOC(=O)c1ncn2c1COc1c(CCN3CCN(c4cc(F)cc5nc(C)ccc45)C[C@H]3C)cccc1-2",
        "output": "484"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.CN(C)C=O.O.O=C(Cl)c1ccc(Br)cc1F>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(Br)cc2F)CC1",
        "output": "201"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNC1.CC(=O)O.CCO.Cc1[nH]c(C=O)c(C)c1C(=O)O.O=C1Cc2cc(F)ccc2N1>>Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)O",
        "output": "911"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)C=O.FC(F)(F)c1cc(Cl)cc(Cl)c1.[Li]CCCC>>O=Cc1c(Cl)cc(C(F)(F)F)cc1Cl",
        "output": "239"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrBr.CO.ClC(Cl)(Cl)Cl.O=S([O-])([O-])=S.[Na+].[Na+].c1ccc(-c2c3ccccc3cc3ccccc23)cc1>>Brc1c2ccccc2c(-c2ccccc2)c2ccccc12",
        "output": "98"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1ccc(-n2cccnc2=O)cc1.O.O=C(O)C(F)(F)F.O=N[O-].[N-]=[N+]=[N-].[Na+].[Na+]>>[N-]=[N+]=Nc1ccc(-n2cccnc2=O)cc1",
        "output": "189"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.O=[N+]([O-])c1cc(OCc2ccccc2)c2ccccc2c1CCO.c1ccncc1>>CC(=O)OCCc1c([N+](=O)[O-])cc(OCc2ccccc2)c2ccccc12",
        "output": "254"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(N)(=O)=O.N#CC1(COc2cc(F)c(C(=O)O)cc2C2CC2)C2CC3CC(C2)CC1C3.NS(=O)(=O)C1CC1.NS(=O)(=O)N1CCC1.O=C(O)c1cc(C2CC2)c(OC2CCC(F)(F)CC2)cc1F>>O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OC2CCC(F)(F)CC2)cc1F",
        "output": "886"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC[C@@H]1C(=O)N(C)c2cc(F)ccc2N1C(=O)c1ccc(O)cc1.CC[C@H]1C(=O)N(C)c2ccc(F)cc2N1C(=O)c1ccc(OC)cc1>>CC[C@H]1C(=O)N(C)c2ccc(F)cc2N1C(=O)c1ccc(O)cc1",
        "output": "786"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.Fc1ccccc1CBr.O=c1[nH]c2c(c3nc(-c4ccccc4F)cn13)CNCC2>>O=c1[nH]c2c(c3nc(-c4ccccc4F)cn13)CN(Cc1ccccc1F)CC2",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(=O)O.CC1(C)C(=O)N(Cl)C(=O)N1Cl.CCN(CC)CC.CCOC(C)=O.Clc1ccnc2cc(SCc3ccccc3)ccc12.O.O=S(=O)(Cl)c1ccc2c(Cl)ccnc2c1.Oc1c(F)c(F)c(F)c(F)c1F>>O=S(=O)(Oc1c(F)c(F)c(F)c(F)c1F)c1ccc2c(Cl)ccnc2c1",
        "output": "380"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Cn1c(CC2CCCCC2)ccc1S(N)(=O)=O.O.O=C1CCC(=O)N1Br>>Cn1c(S(N)(=O)=O)cc(Br)c1CC1CCCCC1",
        "output": "796"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.C1CCOC1.CCOC(=O)C1(CCCBr)CCN(C(=O)OC(C)(C)C)CC1.O>>CCOC(=O)C1(CCCN2CCCCC2)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)Nc1ccc(B(O)O)cc1.COCCOC(=O)Nc1ccc(Cl)c(-c2cn3cc(Br)cnc3n2)c1.[Br-]>>COCCOC(=O)Nc1ccc(Cl)c(-c2cn3cc(-c4ccc(NC(=O)OC)cc4)cnc3n2)c1",
        "output": "871"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1ccc([C@H](C)N)cc1.Cl.O=C(O)c1cc(Cl)cnc1N1CCC(Oc2ccc(F)cc2)C1>>COC(=O)c1ccc([C@H](C)NC(=O)c2cc(Cl)cnc2N2CCC(Oc3ccc(F)cc3)C2)cc1",
        "output": "790"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCCc1c[nH]c2ccc(C(F)(F)F)cc12.O=C(O)c1ccc(Cc2cccc(F)c2)cc1>>O=C(NCCc1c[nH]c2ccc(C(F)(F)F)cc12)c1ccc(Cc2cccc(F)c2)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCCCCCCC/C=C\\CCCCCCCC(=O)O.NCC(O)CO.O.O=C1CCC(=O)N1>>CCCCCCCC/C=C\\CCCCCCCC(=O)NCC(O)CO",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCI.CN(C)C=O.Cn1nnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2cc(C(F)(F)F)ccc2C(O)C2CCOCC2)n1.[H-].[Na+]>>CCOC(c1ccc(C(F)(F)F)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1)C1CCOCC1",
        "output": "307"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCc1nc(CCC)n(-c2ccc3c(c2)CCO3)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCCc1nc(CCC)n(-c2ccc3c(c2)CCO3)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)CC1CCc2c1[nH]c1ccc(OCc3ccc(N4CCCC4)c(C(F)(F)F)c3)cc21.CO.O.O.[Li]O>>O=C(O)CC1CCc2c1[nH]c1ccc(OCc3ccc(N4CCCC4)c(C(F)(F)F)c3)cc21",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O=C(O)c1ccc(Br)cc1O.O=S(=O)(O)O>>COC(=O)c1ccc(Br)cc1O",
        "output": "33"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=CCn1c(N2CCCC(NC(=O)OC(C)(C)C)C2)nc2c1c(=O)n(CC(=O)c1cccc(N)c1)c(=O)n2C.CCN(CC)CC.CN(C)C=O.COC(=O)Cl.ClCCl>>COC(=O)Nc1cccc(C(=O)Cn2c(=O)c3c(nc(N4CCCC(NC(=O)OC(C)(C)C)C4)n3CC=C(C)C)n(C)c2=O)c1",
        "output": "102"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNC1.C1CCOC1.CCN(C(C)C)C(C)C.COc1cc(C(=O)Cl)ccc1[N+](=O)[O-]>>COc1cc(C(=O)N2CCCC2)ccc1[N+](=O)[O-]",
        "output": "201"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)c1ccncc1.COc1ccccc1N.Cc1ccc(S(=O)(=O)Cl)cc1.Cc1ccccc1.O.c1ccncc1>>COc1ccccc1NS(=O)(=O)c1ccc(C)cc1",
        "output": "68"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.COC(=O)Oc1ccc(OC)cc1.COC(Cl)Cl.Cl.ClCCl.Cl[Ti](Cl)(Cl)Cl>>COC(=O)Oc1ccc(OC)c(C=O)c1",
        "output": "591"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cc(C)cc(CCCC(=O)O)c1OC.CS(=O)(=O)O>>COc1cc(C)c2c(c1OC)CCCC2=O",
        "output": "274"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CCC[C@@H](C(=O)N1C(=O)OCC[C@@H]1Cc1ccccc1)[C@H](O)c1ccc(Cl)nc1.CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.Cc1cccc(C)n1.ClCCl>>C#CCC[C@@H](C(=O)N1C(=O)OCC[C@@H]1Cc1ccccc1)[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(Cl)nc1",
        "output": "839"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCc1ccc(C2CC2C(=O)OCC)s1.CO.Cl.O.[Cl-].[K+].[Na+].[OH-]>>CCCCc1ccc(C2CC2C(=O)O)s1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.N[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CS(=O)(=O)N[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1",
        "output": "742"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "N#Cc1cc(Br)c2c(c1)cc1n2CCNC1=O.OB(O)c1cccc(F)c1>>N#Cc1cc(-c2cccc(F)c2)c2c(c1)cc1n2CCNC1=O",
        "output": "833"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCn1nnnc1SCC1=C(C(=O)O)N2C(=O)C(N)[C@H]2SC1.CCOC(C)=O.CN(C)C=O.CON=C(C(=O)O)c1cscn1.C[Si](C)(C)CC(N)=O.O=C([O-])[O-].O=P(Cl)(Cl)Cl.[Cl-].[Na+].[Na+].[Na+]>>C=CCn1nnnc1SCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOC)c3cscn3)[C@H]2SC1",
        "output": "587"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)C[C@@H]1COc2cc(NC3COc4c(-c5c(C)nn(C(F)F)c5C)cccc43)ccc21.[Na+].[OH-]>>Cc1nn(C(F)F)c(C)c1-c1cccc2c1OCC2Nc1ccc2c(c1)OC[C@H]2CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)c1cc2ccc3ccc(-c4ccc(Cl)cc4)c4ccc(c1)c2c34.O=C1CCC(=O)N1Br>>CC(C)(C)c1cc2ccc3c(Br)cc(-c4ccc(Cl)cc4)c4ccc(c1)c2c34",
        "output": "4"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(-c2nnc(Cl)c3cc(OC)ccc23)cc1.NC1CCN(Cc2ccc3ccccc3c2)CC1>>COc1ccc(-c2nnc(NC3CCN(Cc4ccc5ccccc5c4)CC3)c3cc(OC)ccc23)cc1",
        "output": "241"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.C[C@H]1CC(=O)C[C@H](C)N1.ClCCl>>C[C@H]1CC(=O)C[C@H](C)N1C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCCOC.Cc1ccc(S(=O)(=O)Cl)cc1.O=Cc1c[nH]c2ccc(F)cc12.[K+].[OH-]>>Cc1ccc(S(=O)(=O)n2cc(C=O)c3cc(F)ccc32)cc1",
        "output": "648"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Oc1cc(CC(=O)Cl)ccc1[N+](=O)[O-].CCCCC.CCN(CC)CC.CCOC(C)=O.COC(=O)CC(C)c1ccc(N)nc1.ClCCl>>COC(=O)CC(C)c1ccc(NC(=O)Cc2ccc([N+](=O)[O-])c(OC(C)=O)c2)nc1",
        "output": "332"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.COC(=O)C(C)c1cc(F)c(N)cc1F.O=N[O-].O=S(=O)(O)O.[Na+]>>COC(=O)C(C)c1cc(F)c(Br)cc1F",
        "output": "373"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrBr.CCOC(=O)[C@H](Cc1ccc(O)cc1)OCC.ClCCl>>CCOC(=O)[C@H](Cc1ccc(O)c(Br)c1)OCC",
        "output": "98"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(Oc1ccc(C(F)(F)F)cc1)C1CN(C(=O)Cl)CC1c1ccc(Cl)c(Cl)c1.CCN(CC)CC.CN(C)CCN1CCNCC1.ClCCl>>CC(Oc1ccc(C(F)(F)F)cc1)C1CN(C(=O)N2CCN(CCN(C)C)CC2)CC1c1ccc(Cl)c(Cl)c1",
        "output": "258"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)C(=O)Cl.Nc1cccc(Br)n1>>CC(C)C(=O)Nc1cccc(Br)n1",
        "output": "332"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc(Br)ccc1C(=O)O.ClCCl.O=C(Cl)C(=O)Cl>>Cc1cc(Br)ccc1C(=O)Cl",
        "output": "448"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCCC3=O)C(=O)O1.CC(=O)O.O=Cc1ccncc1>>CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCC(=Cc2ccncc2)C3=O)C(=O)O1",
        "output": "85"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.COC(=O)c1ccc(CCCN)s1.O=Cc1ccc(-c2nccs2)cc1>>COC(=O)c1ccc(CCCNCc2ccc(-c3nccs3)cc2)s1",
        "output": "468"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.C[Si](C)(C)CCOCn1ncc2cc(N)ccc21.O=CO>>C[Si](C)(C)CCOCn1ncc2cc(NC=O)ccc21",
        "output": "27"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)c1cc(CO)cc([N+](=O)[O-])c1.[Pd]>>COC(=O)c1cc(N)cc(CO)c1",
        "output": "481"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.Cl.ClCCl.NCCc1c[nH]c2ccc(Cl)cc12.O=C(Cl)Oc1ccccc1>>O=C(NCCc1c[nH]c2ccc(Cl)cc12)Oc1ccccc1",
        "output": "94"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC1CCN(CCO)CC1.Cl>>NC1CCN(CCO)CC1",
        "output": "538"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)C1CCN(Cc2ccc3cc(O[C@@H]4CC[C@H](c5ccccc5)CC4)ccc3c2)CC1.O.[Li+].[OH-]>>O=C(O)C1CCN(Cc2ccc3cc(O[C@H]4CC[C@@H](c5ccccc5)CC4)ccc3c2)CC1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CNC(=O)c1c(-c2ccc(Cl)cc2)oc2cc(N(c3ccc([N+](=O)[O-])c(C#N)c3)S(C)(=O)=O)c(C3CC3)cc12.O.O=S([O-])S(=O)[O-].[Na+].[Na+]>>CNC(=O)c1c(-c2ccc(Cl)cc2)oc2cc(N(c3ccc(N)c(C#N)c3)S(C)(=O)=O)c(C3CC3)cc12",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CCOC(C)=O.COC(=O)Cl.Nc1ccc2c(c1)CCC2=O.O.O=C([O-])O.[Na+]>>COC(=O)Nc1ccc2c(c1)CCC2=O",
        "output": "102"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NCCN.O=C1CCN(CC(F)(F)F)CC1>>CC(C)(C)OC(=O)NCCNC1CCN(CC(F)(F)F)CC1",
        "output": "236"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)OC(=O)Cl.CCN(CC)CC.CCOC(C)=O.Cc1ccccc1.OC1CCNCC1>>CC(C)OC(=O)N1CCC(O)CC1",
        "output": "219"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC(Cn2cc3cc(-c4cn(S(=O)(=O)c5ccccc5)c5cc(F)ccc45)ccc3n2)CC1.CC(C)(C)OC(=O)N1CCC(Cn2ncc3cc(-c4cn(S(=O)(=O)c5ccccc5)c5cc(F)ccc45)ccc32)CC1.CO.O.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(Cn2ncc3cc(-c4c[nH]c5cc(F)ccc45)ccc32)CC1",
        "output": "771"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1C[C@@H](CCl)c2c1cc(N)c1ccccc21.CCN(C(C)C)C(C)C.C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)Cl.ClCCl>>C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)Nc1cc2c(c3ccccc13)[C@H](CCl)CN2C(=O)OC(C)(C)C",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COc1c(C)cnc(COC(C)=O)c1C.[Na+].[OH-]>>COc1c(C)cnc(CO)c1C",
        "output": "348"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2cccc(-c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n2)CC1.Cc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>FC(F)(F)c1cc(-c2cccc(C3CCNCC3)n2)cc(C(F)(F)F)c1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(C(O)(C(C)c2ccc(F)cc2Cl)C(F)(F)F)ccn1.[Li+].[OH-]>>CC(c1ccc(F)cc1Cl)C(O)(c1ccnc(C(=O)O)c1)C(F)(F)F",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(C#CC#CC#CC2CC2)cc1.O.[Na+].[OH-]>>O=C(O)c1ccc(C#CC#CC#CC2CC2)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.Cc1ccc(S(=O)(=O)O)cc1.II.Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21.O.O=N[O-].O=S([O-])([O-])=S.[I-].[K+].[Na+].[Na+].[Na+].[Na+].[OH-]>>O=C1Nc2ncccc2[C@]12Cc1ccc(I)cc1C2",
        "output": "200"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Cl[Sn]Cl.O=C([O-])O.O=[N+]([O-])c1cc(-c2nc3cccnc3[nH]2)cc(-c2ncccc2Cl)c1.[Na+]>>Nc1cc(-c2nc3cccnc3[nH]2)cc(-c2ncccc2Cl)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)O.CCN(CC)CC.CCOC(=O)Cc1c(Cl)ccc2ccc(C=O)cc12.CO.Cl.NCCF.[BH3-]C#N.[Na+]>>CCOC(=O)Cc1c(Cl)ccc2ccc(CNCCF)cc12",
        "output": "468"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(C)=O.C[C@H]1COCCN1c1cc(C(C)(C)S(=O)(=O)C2CCCC2)nc(-c2ccc(N)cc2)n1.O=C(Cl)Oc1ccccc1.O=C([O-])O.[Na+]>>C[C@H]1COCCN1c1cc(C(C)(C)S(=O)(=O)C2CCCC2)nc(-c2ccc(NC(=O)Oc3ccccc3)cc2)n1",
        "output": "102"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(CC)CC.CN1CCCC1=O.Clc1nnc(Cl)c2ccccc12.O.[Cl-].[Na+]>>CC(C)(C)OC(=O)N1CCN(c2nnc(Cl)c3ccccc23)CC1",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=[N+]([O-])c1ccc(-c2ccncc2)cc1.[Pd]>>Nc1ccc(-c2ccncc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NCCCNc1ncc(C=O)s1.CCOCC.Cl.ClCCl>>NCCCNc1ncc(C=O)s1",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(CCO)C1CN(C(=O)OC(C)(C)C)C1.CS(=O)(=O)Cl.ClCCl>>CN(CCOS(C)(=O)=O)C1CN(C(=O)OC(C)(C)C)C1",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.CO.COc1ccc2c(-c3ccc(Cl)cc3)c(Br)c(C)cc2c1.ClCCl>>Cc1cc2cc(O)ccc2c(-c2ccc(Cl)cc2)c1Br",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)C1(NC(=O)c2ccc(OCC)cc2)CC1.CO.O>>CCOc1ccc(C(=O)NC2(C(=O)O)CC2)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc2cc(N)ccc2[nH]1.O=C(c1cc2nccc(Cl)c2s1)N1CC[C@@H](OCC2CC2)C1>>Cc1cc2cc(Nc3ccnc4cc(C(=O)N5CC[C@@H](OCC6CC6)C5)sc34)ccc2[nH]1",
        "output": "927"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(O)c1ccc(F)c(Cl)c1F.O=[N+]([O-])O>>O=C(O)c1cc([N+](=O)[O-])c(F)c(Cl)c1F",
        "output": "21"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCC1CCN(c2ncnc3cc(C(N)=O)sc23)CC1.Cl.O>>NCC1CCN(c2ncnc3cc(C(N)=O)sc23)CC1",
        "output": "538"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.Cc1cc(C)cc(I)c1.N[C@@H]1CCCC[C@H]1N.O=C1CCCN1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>Cc1cc(C)cc(N2CCCC2=O)c1",
        "output": "921"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)CC(N)C(=O)NC(C)(C)C#N.CN(C)C=O.Cl.O=C(O)c1ccc(CBr)cc1.On1nnc2ccccc21>>CC(C)CC(NC(=O)c1ccc(CBr)cc1)C(=O)NC(C)(C)C#N",
        "output": "718"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1nc2ccc(N)cc2c(-c2ccccc2)c1C(=O)OC(C)(C)C.ClCCCl.O=C1Cc2ccccc2C1.[Na+]>>Cc1nc2ccc(NC3Cc4ccccc4C3)cc2c(-c2ccccc2)c1C(=O)OC(C)(C)C",
        "output": "469"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.Cc1cccc(Cl)c1CBr.Fc1cccc2[nH]nc(I)c12.O.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1cccc(Cl)c1Cn1nc(I)c2c(F)cccc21",
        "output": "635"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O.Oc1ccc(F)cc1F.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1ccc(F)cc1F",
        "output": "746"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cc1cc(O)c2cc(Br)ccc2c1.[Pd]>>Cc1cc(O)c2ccccc2c1",
        "output": "350"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CCC1.Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)[nH]ccc2c1>>Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(CC3CCC3)ccc2c1",
        "output": "470"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(CC)C(=O)N[C@H]1C[C@@H]2c3cccc4c3c(c(C=O)n4C)C[C@H]2N(C)C1.CCOC(C)=O.Cl.N.O=C(O)C(O)C(O)C(=O)O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCN(CC)C(=O)N[C@H]1C[C@@H]2c3cccc4c3c(c(CO)n4C)C[C@H]2N(C)C1",
        "output": "745"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cc1c(C(=O)OCc2ccccc2)c(=O)n(-c2ccccc2)n1C[C@@H](C)O.ClCCl>>Cc1c(C(=O)OCc2ccccc2)c(=O)n(-c2ccccc2)n1C[C@@H](C)OC(=O)CNC(=O)OC(C)(C)C",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNC1.CCO.COc1cc(Nc2nc3n(n2)CCC(=O)CC3c2ccc(F)cc2)ccc1-n1cnc(Cl)c1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.[BH3-]C#N.[Na+]>>COc1cc(Nc2nc3n(n2)CCC(N2CCCC2)CC3c2ccc(F)cc2)ccc1-n1cnc(Cl)c1",
        "output": "187"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.O=C(Nc1cc(Oc2ccc([N+](=O)[O-])cc2)ccn1)N1CCC(CN2CCCC2)CC1.[C].[Pd]>>Nc1ccc(Oc2ccnc(NC(=O)N3CCC(CN4CCCC4)CC3)c2)cc1",
        "output": "335"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC(=O)C(F)C1.CCO.CCOC(C)=O.O.[BH4-].[Na+]>>CC(C)(C)OC(=O)N1CCC(O)C(F)C1",
        "output": "91"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=Cc1cccc2c1CCC2=O.CO.Cl.NO.[Cl-].[NH4+].c1ccncc1>>C=Cc1cccc2c1CCC2=NO",
        "output": "212"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(Cn2nc(N3CC4CN(C(=O)OC(C)(C)C)CC4C3)c3c(Oc4ccc(NC(=O)c5ccnn(-c6ccc(F)cc6)c5=O)cc4F)ccnc32)cc1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(Cn2nc(N3CC4CNCC4C3)c3c(Oc4ccc(NC(=O)c5ccnn(-c6ccc(F)cc6)c5=O)cc4F)ccnc32)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "NCC(c1ccccc1)c1ccccc1.O=C(O)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1>>O=C(NCC(c1ccccc1)c1ccccc1)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1c(Br)cccc1C=O.O=c1cc(N2CCNCC2)nc[nH]1>>Cc1c(Br)cccc1CN1CCN(c2cc(=O)[nH]cn2)CC1",
        "output": "567"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.O=C(Cl)OCc1cc(Cl)cc(Cl)c1.O=C(O)CCC1CCNCC1.[Na+].[OH-]>>O=C(O)CCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1",
        "output": "427"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNC1.CN(C)C=O.COC(=O)c1cnc(Cl)cc1C(F)(F)F.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cnc(N2CCCC2)cc1C(F)(F)F",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Nc1cc(C(=O)O)ccn1.CC(C)(C)c1csc(N)n1.ClCCl.O.O=S(Cl)Cl.c1ccncc1>>CC(=O)Nc1cc(C(=O)Nc2nc(C(C)(C)C)cs2)ccn1",
        "output": "918"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cc1ccc(NC(=O)c2cc(F)cc(C(F)(F)F)c2)cc1I.Cc1ccccc1.O.O=C([O-])[O-].O=[N+]([O-])c1cccc(B(O)O)c1.[K+].[K+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1ccc(NC(=O)c2cc(F)cc(C(F)(F)F)c2)cc1-c1cccc([N+](=O)[O-])c1",
        "output": "855"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)c1c(OCc2ccccc2)ccc(Oc2c(C)cc([N+](=O)[O-])c3c2CCC3)c1O.CI.O=C([O-])[O-].[Cs+].[Cs+]>>COc1c(Oc2c(C)cc([N+](=O)[O-])c3c2CCC3)ccc(OCc2ccccc2)c1C(C)=O",
        "output": "62"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(=O)c1cccc(Br)c1.CC(C)(C)[O-].Cc1ccccc1.[Na+].[Pd+2].c1ccc(CN2CCNCC2)cc1>>CC(=O)c1cccc(N2CCN(Cc3ccccc3)CC2)c1",
        "output": "294"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)O.Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1[N+](=O)[O-].[Zn]>>Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)C(=O)Cl.Nc1ccc(-c2cc(=O)c3c(N)c(F)cc(F)c3o2)cc1F.O.c1ccncc1>>CC(C)(C)C(=O)Nc1ccc(-c2cc(=O)c3c(N)c(F)cc(F)c3o2)cc1F",
        "output": "9"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCN(C2CCNCC2)CC1.COc1cc(F)c(F)cc1[N+](=O)[O-].CS(C)=O.O=C([O-])O.[Na+]>>COc1cc(N2CCC(N3CCN(C)CC3)CC2)c(F)cc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3[nH]c(C(=O)O)c(-c4cccnc4)c3c2)cc1.CO.ClCCl.NC1CCOCC1>>CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3[nH]c(C(=O)NC4CCOCC4)c(-c4cccnc4)c3c2)cc1",
        "output": "137"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CI.CN(C)C=O.COc1nccc2c(-c3cc(S(C)(=O)=O)ccc3NCC3CC3)cn(C)c12.[H-].[Na+]>>COc1nccc2c(-c3cc(S(C)(=O)=O)ccc3N(C)CC3CC3)cn(C)c12",
        "output": "377"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C([O-])[O-].O=C1CCCO1.O=[N+]([O-])c1c(F)c(F)c(F)c(F)c1F.O=[N+]([O-])c1ccc(O)cc1OCc1ccccc1.[K+].[K+]>>O=[N+]([O-])c1ccc(Oc2c(F)c(F)c([N+](=O)[O-])c(F)c2F)cc1OCc1ccccc1",
        "output": "564"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1cc(O)c2c(Br)ccc(OCc3ccccc3)c2n1.COC(=O)c1cc(O)c2cc(-c3ccc(Cl)c(Cl)c3)cc(OCc3ccccc3)c2n1>>COC(=O)c1cc(O)c2cc(-c3ccc(Cl)c(Cl)c3)cc(O)c2n1",
        "output": "264"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCCOC.Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1B1OC(C)(C)C(C)(C)O1.ClCCl.Cn1ncc2nc(Cl)nc(N3CCOCC3)c21.O=C([O-])[O-].[Na+].[Na+]>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1nc(N2CCOCC2)c2c(cnn2C)n1",
        "output": "974"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCCCCCCCCCCCCCCCC(N)C(N)=O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCCCCCCCCCCCCCCCCC(N)CN",
        "output": "112"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC2)C[C@H]1C(=O)OCc1ccccc1.CO.O=S(=O)([O-])[O-].[Ba+2].[Pd]>>CC(C)(C)OC(=O)N1CCC2(CC2)C[C@H]1C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CC[C@@H]1NC(=O)C[C@]1(C)O.N#Cc1ccc(I)cc1C(F)(F)F.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>CC[C@@H]1N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C[C@]1(C)O",
        "output": "921"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCOC(=O)c1nc(-c2ccc3c(c2)N(C(=O)OC(C)(C)C)CCC3)sc1CCCCl.[I-].[Na+]>>CCOC(=O)c1nc(-c2ccc3c(c2)N(C(=O)OC(C)(C)C)CCC3)sc1CCCI",
        "output": "97"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1cc2c(=O)n(C(C)C(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3)c2s1.CS(C)=O.ClC(Cl)Cl.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCc1cc2c(=O)n(C(C)C(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c2s1",
        "output": "979"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)CN.COc1c(NS(=O)(=O)c2c(F)cccc2F)cccc1-c1nc(N2CCOCC2)sc1-c1ccnc(Cl)n1>>COc1c(NS(=O)(=O)c2c(F)cccc2F)cccc1-c1nc(N2CCOCC2)sc1-c1ccnc(NCC(C)C)n1",
        "output": "544"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@H]1CC[C@H](O)CC1>>CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](O)CC1",
        "output": "631"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCC.CO.C[O-].Cn1nc(-c2cc(F)c([N+](=O)[O-])cc2F)c(Cl)c1C(F)(F)F.[Na+]>>COc1cc(-c2nn(C)c(C(F)(F)F)c2Cl)c(F)cc1[N+](=O)[O-]",
        "output": "485"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cnc(O)c2ccc(F)cc12.O=P(Cl)(Cl)Cl>>COc1cnc(Cl)c2ccc(F)cc12",
        "output": "41"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Clc1cccc(N2CCNCC2)c1.O=C(O)c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1>>O=C(c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1)N1CCN(c2cccc(Cl)c2)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCOCC.CI.O=C([O-])[O-].O=C1C2=CCCCN2C(=O)N1c1cc(O)c(Cl)cc1F.[Cl-].[K+].[K+].[NH4+]>>COc1cc(N2C(=O)C3=CCCCN3C2=O)c(F)cc1Cl",
        "output": "62"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCC.CCOC(C)=O.COc1cc(N)ccc1-c1cnc(C)s1.Cc1cc(Cc2ccccc2)nc(Cl)n1>>COc1cc(Nc2nc(C)cc(Cc3ccccc3)n2)ccc1-c1cnc(C)s1",
        "output": "808"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCC2=NCCCN2CC1.C1CCOC1.CCCCN(CCCC)C(=O)c1nn(-c2ccc(C(=O)NS(=O)(=O)c3ccc4ccccc4c3)cc2C(=O)N2CCc3ccccc3C2)c(CC(=O)O)c1Cl.CCOC(C)=O.NS(=O)(=O)C1CC1.O=C(n1ccnc1)n1ccnc1>>CCCCN(CCCC)C(=O)c1nn(-c2ccc(C(=O)NS(=O)(=O)c3ccc4ccccc4c3)cc2C(=O)N2CCc3ccccc3C2)c(CC(=O)NS(=O)(=O)C2CC2)c1Cl",
        "output": "644"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNCC1.Cl.O=C(O)CC(=O)O.O=Cc1cccc(Br)c1.c1ccncc1>>O=C(O)C=Cc1cccc(Br)c1",
        "output": "12"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN1CCNCC1.CO.ClCCl.O=Cc1cccc(C(=O)O)n1.[Na+]>>CN1CCN(Cc2cccc(C(=O)O)n2)CC1",
        "output": "829"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)P(=O)(N(C)C)N(C)C.O=C(O)Cc1ccc(NCCC2CCCCC2)cc1.[H-].[Na+]>>COC(=O)Cc1ccc(NCCC2CCCCC2)cc1",
        "output": "415"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cl[Sn]Cl.O.O.O=[N+]([O-])c1ccccc1-c1nc2ccccc2o1>>Nc1ccccc1-c1nc2ccccc2o1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.ClCCl.NN.O=C1c2ccccc2C(=O)N1C(c1ccc2ccc(-c3ccccc3)nc2c1)c1nccnc1Cl>>NC(c1ccc2ccc(-c3ccccc3)nc2c1)c1nccnc1Cl",
        "output": "418"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.O=C(OO)c1cccc(Cl)c1.O=S(=O)(c1ccccc1)n1ccc2ncc(Br)cc21>>O=S(=O)(c1ccccc1)n1ccc2c1cc(Br)c[n+]2[O-]",
        "output": "820"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)CCCC(=O)N3CC(=O)OC)ncc1Cl.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)CCCC(=O)N3CC(=O)O)ncc1Cl",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=Cc1ccc(OCC)cc1.CC#N.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.FC(F)Oc1ccc(Br)cc1.Oc1ccc(Br)cc1.[Pd+2]>>CCOc1ccc(C=Cc2ccc(OC(F)F)cc2)cc1",
        "output": "539"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CNCCN.CNc1cc(Oc2ccc3c(C(=O)NCCN4CCOCC4)cccc3c2)ncn1.O=C(NCCN1CCOCC1)c1cccc2cc(Oc3cc(Cl)ncn3)ccc12>>CNCCNc1cc(Oc2ccc3c(C(=O)NCCN4CCOCC4)cccc3c2)ncn1",
        "output": "166"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCN(CC)C(=O)N(C1CCCCCC1)C1CCN(C(=O)OC(C)(C)C)CC1.Cl>>CCN(CC)C(=O)N(C1CCCCCC1)C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)Cc1c(C)n(Cc2ccccc2S(=O)(=O)c2ccc(F)cc2)c2cc(F)ccc12.Cl.O.[Li+].[OH-]>>Cc1c(CC(=O)O)c2ccc(F)cc2n1Cc1ccccc1S(=O)(=O)c1ccc(F)cc1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC(C(=O)OC)c1c(C)nc(NCc2ccccc2)nc1-c1ccc(C)cc1.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc(NCc2ccccc2)nc1-c1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C[C@@](O)(CN)C(F)(F)F)c1cccc2c1OCC2.Nc1c(C(=O)O)cnn1-c1ccc(F)cc1>>CC(C)(C[C@@](O)(CNC(=O)c1cnn(-c2ccc(F)cc2)c1N)C(F)(F)F)c1cccc2c1OCC2",
        "output": "621"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.ClCCl.Cn1ccc2ncnc(Oc3ccc(N)c(Cl)c3)c21.NCC1CC1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cn1ccc2ncnc(Oc3ccc(NC(=O)NCC4CC4)c(Cl)c3)c21",
        "output": "913"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.COC(=O)C(C)(C)CC(CCCCN)CCCc1cccnc1.ClCCl.O=S(=O)(Cl)c1ccc(Cl)cc1>>COC(=O)C(C)(C)CC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1cccnc1",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cc1cc2c(cc1Sc1nc3c(N)nccc3[nH]1)OCO2.O=C([O-])[O-].O=C1c2ccccc2C(=O)N1CCBr.[Cs+].[Cs+]>>Cc1cc2c(cc1Sc1nc3c(N)nccc3n1CCN1C(=O)c3ccccc3C1=O)OCO2",
        "output": "495"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Cc1ccc(Oc2ccc(Nc3ncnc4cc(-c5cccc(CNC(=O)OC(C)(C)C)c5)[nH]c34)cc2C)cn1.Cl.[Na+].[OH-]>>Cc1ccc(Oc2ccc(Nc3ncnc4cc(-c5cccc(CN)c5)[nH]c34)cc2C)cn1",
        "output": "793"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1cccnc1Br.COCCOC.O.O=C([O-])[O-].OB(O)c1cccc(Cl)c1O.[K+].[K+]>>Oc1c(Cl)cccc1-c1ncccc1Br",
        "output": "869"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCn1ccc2c(C#N)cc(C(=O)OC)cc21.CO.Cl.[Na+].[OH-]>>CCCCn1ccc2c(C#N)cc(C(=O)O)cc21",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)CCNC(=O)c1ccc(-c2cc(F)c(F)cc2C(=O)Nc2ccc(-c3ccc(Cl)cc3Cl)cc2)cn1.[Na+].[OH-]>>O=C(O)CCNC(=O)c1ccc(-c2cc(F)c(F)cc2C(=O)Nc2ccc(-c3ccc(Cl)cc3Cl)cc2)cn1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1c2n(c3c(Br)cc(F)cc13)CCNC2=O.OB(O)c1ccc(F)cc1F>>Cc1c2n(c3c(-c4ccc(F)cc4F)cc(F)cc13)CCNC2=O",
        "output": "833"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#Cc1ccc(C2(NC(=O)OC(C)(C)C)CCC2)cc1.CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C.CCN(CC)CC.COc1c(Br)cccc1C#N.ClCCl.[Cu]I>>COc1c(C#N)cccc1C#Cc1ccc(C2(NC(=O)OC(C)(C)C)CCC2)cc1",
        "output": "659"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)C(=O)c1cn(Cc2ccccc2)c2c(-c3ccc(OC(F)(F)F)cc3)cccc12.O.[K+].[OH-]>>O=C(O)C(=O)c1cn(Cc2ccccc2)c2c(-c3ccc(OC(F)(F)F)cc3)cccc12",
        "output": "472"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)C(CO)C1(C)C.CN(C)C=O.Cc1ccccc1.Fc1ccc(CBr)cc1Br.[Cl-].[H-].[NH4+].[Na+]>>CC1(C)C(COCc2ccc(F)c(Br)c2)C1(C)C",
        "output": "464"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.CNOC.Cl.O.O=C(O)c1cn(Cc2cccc(Br)n2)c2ccccc2c1=O>>CON(C)C(=O)c1cn(Cc2cccc(Br)n2)c2ccccc2c1=O",
        "output": "879"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Cc1ccsc1Br.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>Cc1cc(C=O)sc1Br",
        "output": "617"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CCN(CC)CC.Cl.ClCCl.Nc1ncc(-c2cn(C3CCNCC3)nc2C=O)cc1-c1nc2ccccc2o1>>CC(=O)N1CCC(n2cc(-c3cnc(N)c(-c4nc5ccccc5o4)c3)c(C=O)n2)CC1",
        "output": "125"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CN1C(=O)CC[C@]2(C)c3ccc(Br)cc3CC[C@@H]12.COc1cc(B(O)O)ccc1O.ClC(Cl)Cl.O=C([O-])[O-].[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc(-c2ccc3c(c2)CC[C@H]2N(C)C(=O)CC[C@]32C)ccc1O",
        "output": "837"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCNCc1ccccc1[N+](=O)[O-].CCO.[H][H].[Pd]>>CCNCc1ccccc1N",
        "output": "588"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCc1ccccc1.CN(C)C=O.Cl.Cl.NC[C@@H]1C[C@@H](C(=O)Nc2ccc(Oc3ccc(F)cc3)cc2)N(C(=O)Cn2cncn2)C1.O=C([O-])[O-].[K+].[K+]>>O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](CNCc2ccccc2)CN1C(=O)Cn1cncn1",
        "output": "446"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.Nc1ccc(S[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1.O>>CC(=O)Nc1ccc(S[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1",
        "output": "6"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)c1ccc(CN(C)C(=O)OC(C)(C)C)s1.[Na+].[OH-]>>CN(Cc1ccc(C(=O)O)s1)C(=O)OC(C)(C)C",
        "output": "152"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1c(I)c(CC)c(I)c(-c2ccc(C(=O)O)c([N+](=O)[O-])c2)c1I.Cc1ccc(-c2c(I)cc(I)cc2I)cc1.O=S(Cl)Cl.[Zn]>>CCc1c(I)c(CC)c(I)c(-c2ccc(C(=O)Cl)c([N+](=O)[O-])c2)c1I",
        "output": "3"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cc1ccc(Cl)cc1C1=CCN(C(=O)OC(C)(C)C)CC1.[H][H].[Pt]>>Cc1ccc(Cl)cc1C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "806"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1CCC(N(C(=O)Nc2ncc(CN3CCN(S(=O)(=O)N(C)C)CC3)s2)C2CCNCC2)CC1.Cl.O=C(Cl)C1CCCC1>>CC1CCC(N(C(=O)Nc2ncc(CN3CCN(S(=O)(=O)N(C)C)CC3)s2)C2CCN(C(=O)C3CCCC3)CC2)CC1",
        "output": "125"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C(OCCCO)c1[nH]c(-c2ccccc2)c2cc(Cl)ccc12>>CS(=O)(=O)OCCCOC(=O)c1[nH]c(-c2ccccc2)c2cc(Cl)ccc12",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CO[C@H](C)[C@H](N)C(=O)O.O.O=C([O-])O.[Na+]>>CO[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)O",
        "output": "626"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)(C)COCC(=O)O.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1nc2cccc(O[C@@H]3CC[C@@H](N)CC3)c2c(N)c1C(=O)O.Cl.O=C([O-])O.On1nnc2ccccc21.[Na+]>>Cc1nc2cccc(O[C@@H]3CC[C@@H](NC(=O)COCC(C)(C)C)CC3)c2c(N)c1C(=O)O",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.O=C([O-])[O-].[Na+].[Na+].c1ccc(N2CCC3(CC2)OCCO3)nc1>>O=C1CCN(c2ccccn2)CC1",
        "output": "251"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CS(C)=O.C[Si](C)(C)CCOCn1ccc2c1ncc1c(=O)ncn([C@@H]3CC[C@@H](CO)CC3)c12.O.O=C(O)c1ccccc1I(=O)=O.O=S([O-])([O-])=S.[Na+].[Na+]>>C[Si](C)(C)CCOCn1ccc2c1ncc1c(=O)ncn([C@@H]3CC[C@@H](C=O)CC3)c12",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(O)C(=O)O.Cc1c(CN2CCNCC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12.Cl>>Cc1c(CN2CCN(C(=O)C(C)(C)O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.C1COCCO1.COC(=O)c1ccc2nc(Cl)c(N(C)C(C)C)nc2c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].OB(O)c1ccc2c(c1)OCO2.[K+].[K+].[K+].[Pd].[Pd]>>COC(=O)c1ccc2nc(-c3ccc4c(c3)OCO4)c(N(C)C(C)C)nc2c1",
        "output": "875"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.ClCCl.O.O=C1CN(c2ccc(-c3nccs3)cc2OCc2ccccc2)S(=O)(=O)N1>>O=C1CN(c2ccc(-c3nccs3)cc2O)S(=O)(=O)N1",
        "output": "23"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)/C=C/c1cc(Cl)cc(Cl)c1.[Na+].[OH-]>>O=C(O)/C=C/c1cc(Cl)cc(Cl)c1",
        "output": "58"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)c1ccc(C(=O)O)cc1.COc1cc(OC)c(-c2ccc(C)s2)cc1C=O>>COc1cc(OC)c(-c2ccc(C)s2)cc1/C=C/C(=O)c1ccc(C(=O)O)cc1",
        "output": "656"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)Cc1ccc(C(C)C(=O)Oc2ccc(C(=O)OCC(O)CO)cc2)cc1.CN(C)c1ccncc1.ClCCl.O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl.Oc1cc(OCc2ccccc2)cc(OCc2ccccc2)c1>>O=C(Cc1ccccc1Nc1c(Cl)cccc1Cl)Oc1cc(OCc2ccccc2)cc(OCc2ccccc2)c1",
        "output": "108"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCCN(c2c(C=O)c3cccnc3n2-c2ccccc2)CC1.CCOCC.ClCCl.O=C(O)C(F)(F)F>>O=Cc1c(N2CCCNCC2)n(-c2ccccc2)c2ncccc12",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1cc2oc(=O)cc(C(C)C)c2cc1O.ClCCCN1CCN(c2ccccc2)CC1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>COc1cc2oc(=O)cc(C(C)C)c2cc1OCCCN1CCN(c2ccccc2)CC1",
        "output": "74"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC1(C)OB(c2cccc(OCC(O)CN3CCc4ccccc4C3)c2)OC1(C)C.Cc1cn(C)c2cc(Br)ccc12.Cl[Pd]Cl.O.O=C([O-])[O-].[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cn(C)c2cc(-c3cccc(OCC(O)CN4CCc5ccccc5C4)c3)ccc12",
        "output": "972"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)C=O.OCc1nc2ccccc2[nH]1>>CC(C)(C)[Si](C)(C)OCc1nc2ccccc2[nH]1",
        "output": "193"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C=CCBr.O.OC(c1cccnc1)c1ccc(Cl)cc1Cl.[H-].[Na+]>>C=CCOC(c1cccnc1)c1ccc(Cl)cc1Cl",
        "output": "120"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2ccc(C(C)C(O)(c3ccc4oc(=O)n(C)c4c3)C(F)(F)F)c(Cl)c2)cc1F.Cl.[Li+].[OH-]>>CC(c1ccc(-c2ccc(C(=O)O)c(F)c2)cc1Cl)C(O)(c1ccc2oc(=O)n(C)c2c1)C(F)(F)F",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.O.O.O=[N+]([O-])c1ccc(N2CCC(C(c3ccccn3)c3ccccn3)CC2)c(F)c1.[Cl-]>>Nc1ccc(N2CCC(C(c3ccccn3)c3ccccn3)CC2)c(F)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(CN)cc1C.O=C(O)Cc1cccc(Br)c1>>Cc1ccc(CNC(=O)Cc2cccc(Br)c2)cc1C",
        "output": "599"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NC1CCN(c2ccc(C(=O)N3CCCCC3)cn2)CC1.ClCCl.O=C(O)C(F)(F)F>>NC1CCN(c2ccc(C(=O)N3CCCCC3)cn2)CC1",
        "output": "538"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.N#CCCc1ccc(Cl)c(CO)c1>>N#CCCc1ccc(Cl)c(C=O)c1",
        "output": "179"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)Cc1cnc(NC(=O)OC(C)(C)C)cn1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(C)OC(=O)Nc1cnc(CCO)cn1",
        "output": "343"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCN(CC(=O)O)C(=O)C(CCC(=O)OC)CS(=O)(=O)c1ccc2ccccc2c1.CCN(CC)CC.CCOP(=O)(C#N)OCC.CN(C)C=O.CNC.Cl.Cl>>CCCCCN(CC(=O)N(C)C)C(=O)C(CCC(=O)OC)CS(=O)(=O)c1ccc2ccccc2c1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC[SiH](CC)CC.ClCCl.O=C(O)C(F)(F)F.O=C1N(C(c2ccccc2)c2ccccc2)c2ccccc2C1(O)c1cc2c(cc1OCc1ccccc1)OCO2>>O=C1C(c2cc3c(cc2OCc2ccccc2)OCO3)c2ccccc2N1C(c1ccccc1)c1ccccc1",
        "output": "964"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1ccc(Nc2c(C(=O)O)ccc(F)c2F)c(F)c1.COc1nc(OC)nc([N+]2(C)CCOCC2)n1.NOCCO.[Cl-]>>COC(=O)c1ccc(Nc2c(C(=O)NOCCO)ccc(F)c2F)c(F)c1",
        "output": "741"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CCO.CCOC(C)=O.Cl.NO.O.O.O.O.O=C(CCN1CCCC(c2nccs2)C1)c1ccc(F)cc1.[Na+]>>ON=C(CCN1CCCC(c2nccs2)C1)c1ccc(F)cc1",
        "output": "212"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ccccc1[N+](=O)[O-]>>O=C(Cl)c1ccccc1[N+](=O)[O-]",
        "output": "448"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CCC(c1ccc(-c2ccc(OC)cc2)s1)n1ccnc1.ClCCl>>CCC(c1ccc(-c2ccc(O)cc2)s1)n1ccnc1",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=Cc1ccncc1.CC#N.O=[N+]([O-])c1ccc(I)cc1>>O=[N+]([O-])c1ccc(C=Cc2ccncc2)cc1",
        "output": "725"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.Cc1ccccc1.O=C(Cl)C(Cl)Cl.O=[N+]([O-])c1ccc(N2CCNCC2)cc1>>O=C(C(Cl)Cl)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1",
        "output": "125"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCOC(=O)c1ccc([C@H](C)n2nc(-c3cc(Cl)cc(Cl)c3)cc2-c2ccc3cc(OC)ccc3c2)cc1.CO.O.[Na+].[OH-]>>COc1ccc2cc(-c3cc(-c4cc(Cl)cc(Cl)c4)nn3[C@@H](C)c3ccc(C(=O)O)cc3)ccc2c1",
        "output": "5"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O.COc1cccc2c1CCNC2>>COc1cccc2c1CCN(C(=O)c1cc(S(C)(=O)=O)ccc1OC(C)C)C2",
        "output": "794"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cnc2cc(OCC3COC(C)(C)O3)ccn12.ClCCl.O.O.O.[Li+].[OH-]>>CC1(C)OCC(COc2ccn3c(C(=O)O)cnc3c2)O1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCC1CO1.Oc1ccc(OC(F)(F)F)cc1>>FC(F)(F)Oc1ccc(OCC2CO2)cc1",
        "output": "15"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)CCc1ccccc1OCCCCOc1cc(O)c(-c2ccc(F)cc2)cc1CC.Cl.[Na+].[OH-]>>CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCCOc1ccccc1CCC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O=S(=O)(c1ccccc1)n1cc(-c2ccc3ccsc3c2)c2ccc(F)cc21.O=S(=O)(c1ccccc1)n1cc(I)c2ccc(F)cc21>>Fc1ccc2c(-c3ccc4ccsc4c3)c[nH]c2c1",
        "output": "771"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1ccc2c(c1)c1c(C(N)=O)cc(-c3c(C)noc3C)cc1n2Cc1ccccc1.CO.[Na+].[OH-]>>Cc1noc(C)c1-c1cc(C(N)=O)c2c3cc(C(=O)O)ccc3n(Cc3ccccc3)c2c1",
        "output": "5"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1.Nc1ccc(-c2cnc(CNS(=O)(=O)C(F)(F)F)s2)cc1.O=C=NC1CCCCC1>>O=C(Nc1ccc(-c2cnc(CNS(=O)(=O)C(F)(F)F)s2)cc1)NC1CCCCC1",
        "output": "176"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.O.O=Cc1cc2ncnc(Cl)c2s1.[BH4-].[Na+]>>OCc1cc2ncnc(Cl)c2s1",
        "output": "529"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)CC(=O)O.Cl.Cl.ClCCl.Nc1ncnc2c1c(I)nn2C1CCNC1.O.On1nnc2cccnc21>>CN(C)CC(=O)N1CCC(n2nc(I)c3c(N)ncnc32)C1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COC(=O)C(C(=O)Nc1ccc(C#Cc2ccc(C=O)cc2)cc1)C(C)C.ClCCCl.[Na+]>>COC(=O)C(C(=O)Nc1ccc(C#Cc2ccc(CN3CCOCC3)cc2)cc1)C(C)C",
        "output": "567"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COc1ncccc1-c1ncc(-c2cccc(Nc3cc(C)ccn3)n2)o1.Cl.O>>Cc1ccnc(Nc2cccc(-c3cnc(-c4ccc[nH]c4=O)o3)n2)c1",
        "output": "758"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CN.Cc1nc(C(F)(F)F)ccc1C(=O)O>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1ccc(C(F)(F)F)nc1C",
        "output": "674"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C.CC(C)[Si](Cl)(C(C)C)C(C)C.CN(C)C=O.ClCCl.c1c[nH]cn1>>CC(=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)CC[C@]4(C)[C@H]3CC[C@]12C",
        "output": "193"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O=C(Nc1ccccc1)c1ccccc1[N+](=O)[O-].[B][B][B][B][B][B][B][B][B][B].[Pd]>>Nc1ccccc1C(=O)Nc1ccccc1",
        "output": "486"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC1)CC(C#N)C2.O=C(O)C(F)(F)F>>N#CC1CC2(CCNCC2)C1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CNc1nccc(-c2cc(NC3CCN(C(=O)OCC4c5ccccc5-c5ccccc54)CC3)c3cc(OC)ccc3c2)n1.ClC(Cl)Cl>>CNc1nccc(-c2cc(NC3CCN(C(=O)OCC4c5ccccc5-c5ccccc54)CC3)c3cc(O)ccc3c2)n1",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCc2c(c(-c3ccc(C(F)(F)F)cc3)nn2CCC=O)C1.ClCCl.Cn1c(=O)n(C2CCNCC2)c2ccccc21.O=C([O-])O.[Na+].[Na+]>>Cn1c(=O)n(C2CCN(CCCn3nc(-c4ccc(C(F)(F)F)cc4)c4c3CCN(C(=O)OC(C)(C)C)C4)CC2)c2ccccc21",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCON=C(c1ccc(Br)cc1)C1CCN(C2(C)CCNCC2)CC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc2nccc(C(=O)O)c2c1.F[P-](F)(F)(F)(F)F>>CCON=C(c1ccc(Br)cc1)C1CCN(C2(C)CCN(C(=O)c3ccnc4ccc(C)cc34)CC2)CC1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1cccc(-c2ccc(N3CCN(C4CC4)CC3)nn2)c1.O=C(Cl)C1CC1>>O=C(Nc1cccc(-c2ccc(N3CCN(C4CC4)CC3)nn2)c1)C1CC1",
        "output": "9"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)C1CN(C(=O)OC(C)(C)C)CC1c1ccc(F)cc1.Cl.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CC(C(=O)O)C(c2ccc(F)cc2)C1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNC.F[P-](F)(F)(F)(F)F.O=C(O)c1cc(Br)ccc1I>>CN(C)C(=O)c1cc(Br)ccc1I",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCCC1=O.Cc1cc(N)c2ccccc2n1.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[K+].[K+]>>Cc1cc(Nc2ccc([N+](=O)[O-])cc2)c2ccccc2n1",
        "output": "609"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)N=C=O.COc1ccccc1Nc1nc2ccc(-c3cccc(N)c3)cn2n1.O>>COc1ccccc1Nc1nc2ccc(-c3cccc(NC(=O)NC(C)C)c3)cn2n1",
        "output": "176"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)CC1COC1.Cl.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3OCC4)CC2)CC1>>O=C(CC1COC1)N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3OCC4)CC2)CC1",
        "output": "392"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.C1COCCO1.CC(C)(C)OC(=O)Nc1ccc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)cc2)cc1.Cl.O=C([O-])O.[Na+]>>Nc1ccc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)cc2)cc1",
        "output": "782"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc2c(c1)OC[C@@H](c1c(F)c(F)c(F)c(F)c1F)[C@H]2c1ccc(OCCN2CCCC2)cc1.Cl.c1ccncc1>>Oc1ccc2c(c1)OC[C@@H](c1c(F)c(F)c(F)c(F)c1F)[C@H]2c1ccc(OCCN2CCCC2)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(C)=O.Cl.ClCc1ccc(Cl)cc1.O.O=C1NC(=O)C(Cc2ccc(O)cc2)S1.[H-].[Na+]>>O=C1NC(=O)C(Cc2ccc(OCc3ccc(Cl)cc3)cc2)S1",
        "output": "49"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CCN(CCC[C@H](NC(=O)OC(C)(C)C)C(=O)O)C1C[C@H]1c1ccc(F)cc1.OC1CCNCC1>>C=CCN(CCC[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC(O)CC1)C1C[C@H]1c1ccc(F)cc1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(C)Cc1c(OCc2ccc(C#N)nc2)ccc2c(CCC3CCNCC3)noc12.ClCCl.O=C([O-])O.O=C([O-])[O-].O=Cc1ccccc1.[Na+].[Na+].[Na+].[Na+]>>CN(C)Cc1c(OCc2ccc(C#N)nc2)ccc2c(CCC3CCN(Cc4ccccc4)CC3)noc12",
        "output": "567"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CO.COC(=O)c1cccn(-c2ccccc2)c1=O.Cl.O.[Li+].[OH-]>>O=C(O)c1cccn(-c2ccccc2)c1=O",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1CCNCC1.Cc1ccccc1.Fc1cc(N(Cc2ccccc2)Cc2ccccc2)c(F)cc1Br.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2]>>CC(C)(C)OC(=O)N1CCN(c2cc(F)c(N(Cc3ccccc3)Cc3ccccc3)cc2F)CC1",
        "output": "294"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(=O)CN(c1ncnc2c1ccn2S(=O)(=O)c1ccc(C)cc1)[C@@H]1CCCNC1.CCOC(C)=O.CN(C)C=O.O=C(O)CNc1cc(Cl)cc(Cl)c1.On1nnc2ccccc21>>CCOC(=O)CN(c1ncnc2c1ccn2S(=O)(=O)c1ccc(C)cc1)[C@@H]1CCCN(C(=O)CNc2cc(Cl)cc(Cl)c2)C1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(C(=O)O)c1.Cc1nc(-c2c(Cl)c3ccccc3n2-c2ccc(CNC(=O)C3(N)CC3)cc2)no1>>Cc1nc(-c2c(Cl)c3ccccc3n2-c2ccc(CNC(=O)C3(NC(=O)c4cccc(NC(=O)OC(C)(C)C)c4)CC3)cc2)no1",
        "output": "718"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1sc(C(=O)NCc2cccc3[nH]ccc23)cc1C(F)(F)F.Cl.O.O.[Li+].[OH-]>>O=C(NCc1cccc2[nH]ccc12)c1cc(C(F)(F)F)c(C(=O)O)s1",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Cc1nc(N)ccc1C(=O)O.O=S(=O)(O)O.[Na+].[OH-]>>COC(=O)c1ccc(N)nc1C",
        "output": "521"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCOC(=O)CC1CCCn2c1cc1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc12.[Li+].[OH-]>>O=C(O)CC1CCCn2c1cc1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc12",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCn2c(S(C)(=O)=O)nc(C(F)(F)F)c2C1CCc1ccc(C(F)(F)F)cc1.CCO.CC[O-].[Na+]>>CCOc1nc(C(F)(F)F)c2n1CCN(C(=O)OC(C)(C)C)C2CCc1ccc(C(F)(F)F)cc1",
        "output": "667"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CI.O.OCCCSc1cccc2nccn12.[H-].[Na+]>>COCCCSc1cccc2nccn12",
        "output": "140"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1cc(Br)cc2c(C3CCSC3)c[nH]c12.COCCOC.O.O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O.O=C([O-])O.O=S([O-])OO.[K+].[Na+]>>CCOC(=O)c1cc(Br)cc2c(C3CCS(=O)(=O)C3)c[nH]c12",
        "output": "847"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)c1cnc(-c2ncccn2)nc1Oc1ccccc1C.Cl>>Cc1ccccc1Oc1nc(-c2ncccn2)ncc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cccc(Br)c1OC.Cc1ccccc1.O.[Al+3].[Cl-].[Cl-].[Cl-]>>Oc1cccc(Br)c1O",
        "output": "19"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)/C(=C/C1CCCC1)c1ccc(S(=O)(=O)CC2CC2)cc1.Cl.[K+].[OH-]>>O=C(O)/C(=C/C1CCCC1)c1ccc(S(=O)(=O)CC2CC2)cc1",
        "output": "122"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=O.CC(=O)O.CO.C[C@@H]1C(=O)NN=C2COc3cc(Br)c([C@@H]4CCNC[C@@H]4C)cc3N21.O=C([O-])O.[BH3-]C#N.[Na+].[Na+]>>C[C@@H]1C(=O)NN=C2COc3cc(Br)c([C@@H]4CCN(C)C[C@@H]4C)cc3N21",
        "output": "217"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1nc(C)c(C(=O)Nc2ccc(F)c(-c3cn4cc(C5CCNCC5)cnc4n3)c2)o1.O=C(O)CO>>Cc1nc(C)c(C(=O)Nc2ccc(F)c(-c3cn4cc(C5CCN(C(=O)CO)CC5)cnc4n3)c2)o1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.Cc1nc2ccccc2[nH]1.ClCCCCBr.ClCCl.[Br-].[Na+].[OH-]>>Cc1nc2ccccc2n1CCCCCl",
        "output": "276"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CC(C)C1CCC(C)(Cl)C(Cl)C1.CCn1c(-c2nonc2N)nc2cncc(CNC3CCN(C(=O)OC(C)(C)C)CC3)c21.O=C([O-])[O-].[K+].[K+]>>CCn1c(-c2nonc2N)nc2cncc(CN(C(C)=O)C3CCN(C(=O)OC(C)(C)C)CC3)c21",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(C)=O.O.O=[N+]([O-])c1cccc(Nc2ncc3ccccn23)c1.[Cl-].[Fe].[NH4+]>>Nc1cccc(Nc2ncc3ccccn23)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=O)Nc1cccc(C2CCNCC2)c1.ClCCCCCSc1ccccc1>>CCC(=O)Nc1cccc(C2CCN(CCCCCSc3ccccc3)CC2)c1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C(C)(Cc1ccc(O)cc1)Oc1ccccc1.CCOC(C)=O.CN(C)C=O.Cc1ccc(S(=O)(=O)OCCc2nc(-c3ccc(-c4ccccc4)cc3)oc2C)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)C(C)(Cc1ccc(OCCc2nc(-c3ccc(-c4ccccc4)cc3)oc2C)cc1)Oc1ccccc1",
        "output": "438"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(=O)(=O)OCC1(c2ccc(Br)cc2)CCCC1.CS(C)=O.O.[C-]#N.[Na+]>>N#CCC1(c2ccc(Br)cc2)CCCC1",
        "output": "705"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CNCCN1.Clc1nc(N2CCOCC2)c2ncnc(SCc3ccco3)c2n1>>c1coc(CSc2ncnc3c(N4CCOCC4)nc(N4CCNCC4)nc23)c1",
        "output": "36"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC)C(=O)C1CCCNC1.CCO.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)ccc2Oc2ccnc(Cl)n2)cc1.O=C([O-])O.[Na+]>>CCN(CC)C(=O)C1CCCN(c2nccc(Oc3ccc(F)cc3CNC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)n2)C1",
        "output": "36"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCN2C(=O)CCC2(Cc2ccccn2)C1.CCOCC.Cl>>CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCN2C(=O)CCC2(Cc2ccccn2)C1",
        "output": "431"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)C(=O)Cl.CCN(CC)CC.Cl.Cl.NCc1ccc(Cl)c(C(=O)Nc2ncc[nH]2)c1>>CC(C)C(=O)NCc1ccc(Cl)c(C(=O)Nc2ncc[nH]2)c1",
        "output": "206"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(F)(F)S(=O)(=O)c2cccnc2Cl)CC1.CCO.N>>CC(C)(C)OC(=O)N1CCC(C(F)(F)S(=O)(=O)c2cccnc2N)CC1",
        "output": "388"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1ccc(-c2cc3cc[nH]c3cc2C#N)cc1.O=P(Cl)(Cl)Cl>>COc1ccc(-c2cc3c(C=O)c[nH]c3cc2C#N)cc1",
        "output": "266"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCC(=O)N[C@@H](Cc1ccccc1)C(=O)OCC.CO.[Na+].[OH-]>>CCCCC(=O)N[C@@H](Cc1ccccc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COCCOCCCN.Clc1nc(Cl)c2ncn(C3CCCC3)c2n1>>COCCOCCCNc1nc(Cl)nc2c1ncn2C1CCCC1",
        "output": "145"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NCCO.O=C(NC(Cc1ccc(OC(F)(F)F)cc1)C(=O)O)c1ccc(Oc2ccc(Cl)cc2)cc1>>O=C(NC(Cc1ccc(OC(F)(F)F)cc1)C(=O)NCCO)c1ccc(Oc2ccc(Cl)cc2)cc1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.Cc1c(-c2ccc(O)cc2)ccc2c1ncn2C(c1ccccc1)(c1ccccc1)c1ccccc1.Cc1ccc(S(=O)(=O)OCCCl)cc1.O=C([O-])[O-].[K+].[K+]>>Cc1c(-c2ccc(OCCCl)cc2)ccc2c1ncn2C(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "438"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cn1nc(-c2cnc3c(n2)c(C(=O)N[C@@H]2CCN(Cc4ccccc4)C2)cn3COCC[Si](C)(C)C)c2ccc(F)cc21.[F-]>>Cn1nc(-c2cnc3[nH]cc(C(=O)N[C@@H]4CCN(Cc5ccccc5)C4)c3n2)c2ccc(F)cc21",
        "output": "981"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.N#CCCN.O=Cc1cccs1.[Na+]>>N#CCCNCc1cccs1",
        "output": "691"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN=C=NCCCN(C)C.COC(=O)C[C@@H]1NCCN(CC(=O)OC(C)(C)C)C1=O.C[C@H](NC(=O)OCc1ccccc1)C(=O)O.Cl.O=S(=O)([O-])O.[K+]>>COC(=O)C[C@H]1C(=O)N(CC(=O)OC(C)(C)C)CCN1C(=O)[C@H](C)NC(=O)OCc1ccccc1",
        "output": "297"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C(O)(CS(=O)(=O)c1ccc(OC)cc1)CS(=O)(=O)c1ccc(-c2ccccc2)cc1.CO.[Na+].[OH-]>>COc1ccc(S(=O)(=O)CC(O)(CS(=O)(=O)c2ccc(-c3ccccc3)cc2)C(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)Cn1ccnc1CCC(=O)N1CCC(N2CCCCC2)CC1.O>>O=C(O)Cn1ccnc1CCC(=O)N1CCC(N2CCCCC2)CC1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CI.CN(C)C=O.Cc1nccc(CC(=O)O)c1OCc1ccccc1.O=C([O-])O.O=C([O-])[O-].[K+].[K+].[Na+]>>COC(=O)Cc1ccnc(C)c1OCc1ccccc1",
        "output": "415"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)COc1ccc(CN(CCOC)c2cccc(-c3ccc(C(F)(F)F)cc3)c2C)cc1C.CO.[Na+].[OH-]>>COCCN(Cc1ccc(OCC(=O)O)c(C)c1)c1cccc(-c2ccc(C(F)(F)F)cc2)c1C",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)Oc1ccc(Br)cc1C.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>COC(=O)Oc1cc([N+](=O)[O-])c(Br)cc1C",
        "output": "103"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)[C@H](N)C(=O)NC(CC(=O)OC(C)(C)C)C(O)COc1c(F)c(F)cc(F)c1F.CCN=C=NCCCN(C)C.CN1CCOCC1.ClCCl.Cn1c(C(=O)O)cc2ccccc21.On1nnc2ccccc21>>CC(C)[C@H](NC(=O)c1cc2ccccc2n1C)C(=O)NC(CC(=O)OC(C)(C)C)C(O)COc1c(F)c(F)cc(F)c1F",
        "output": "738"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NC(c1ccccn1)C(F)(F)F.O=C(O)c1cc(OCC2CC2)c(C2CC2)cn1>>O=C(NC(c1ccccn1)C(F)(F)F)c1cc(OCC2CC2)c(C2CC2)cn1",
        "output": "137"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(N)cn1.C[C@@](O)(C(=O)Nc1ccc(S(=O)(=O)Cl)c(Cl)c1Cl)C(F)(F)F.ClCCl.c1ccncc1>>COc1ccc(NS(=O)(=O)c2ccc(NC(=O)[C@@](C)(O)C(F)(F)F)c(Cl)c2Cl)cn1",
        "output": "554"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cnn(CC(F)(F)F)c1-c1ncccc1Cl.Cl.O.[Li+].[OH-]>>O=C(O)c1cnn(CC(F)(F)F)c1-c1ncccc1Cl",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)OCC(C)(C)C(C(=O)NCCC(=O)O)O1.CCCCCCCC/C=C\\CCCCCCCC(=O)NCCCCCN>>CCCCCCCC/C=C\\CCCCCCCC(=O)NCCCCCNC(=O)CCNC(=O)C1OC(C)(C)OCC1(C)C",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.O=Cc1ccc([N+](=O)[O-])c(CS(=O)(=O)c2cccc3ccccc23)c1.[Pd]>>Nc1ccc(C=O)cc1CS(=O)(=O)c1cccc2ccccc12",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.OCC1CCCN1>>CC(C)(C)OC(=O)N1CCCC1CO",
        "output": "694"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1cc(-c2cccc3c2[nH]c2ccccc23)cc(-c2cccc3c2[nH]c2ccccc23)c1.C1CCOC1.COB(OC)OC.Cl.[Li]CCCC>>OB(O)c1cc(-c2cccc3c2[nH]c2ccccc23)cc(-c2cccc3c2[nH]c2ccccc23)c1",
        "output": "789"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCOCCCCO.CCN(CC)CC.CS(C)=O.ClC(Cl)Cl.[Cl-]>>C=CCOCCCC=O",
        "output": "142"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "N#CC1(c2ccccc2)CC1.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>N#CC1(c2ccc([N+](=O)[O-])cc2)CC1",
        "output": "103"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)C=O.CNc1cc(-c2cccc(N)c2)nc(N)n1.O=C(O)CCC(=O)N1CCCC1.Oc1cccc2[nH]nnc12>>CNc1cc(-c2cccc(NC(=O)CCC(=O)N3CCCC3)c2)nc(N)n1",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cccc(-c2cc(C(=O)NCCCCCCCc3ccccc3)cc(-c3cccc(C)c3)c2OCC(=O)OC(C)(C)C)c1.O=CO>>Cc1cccc(-c2cc(C(=O)NCCCCCCCc3ccccc3)cc(-c3cccc(C)c3)c2OCC(=O)O)c1",
        "output": "278"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(=C(c1ccc(O)cc1)c1ccc(OCCBr)c(Br)c1)c1ccccc1.CN.CO>>CCC(=C(c1ccc(O)cc1)c1ccc(OCCNC)c(Br)c1)c1ccccc1",
        "output": "147"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc(C(C)(C)C#N)c1.O.O.[Li]O>>CC(C)(C#N)c1cccc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCOc1ccc(C=O)cc1.CCN(CC)CC.CCOC(=O)c1ccc(C(C)=O)cc1.CCOC(C)=O.ClCCl.Cl[Ti](Cl)(Cl)Cl>>CCCCCOc1ccc(C=CC(=O)c2ccc(C(=O)OCC)cc2)cc1",
        "output": "295"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)COc1cccc(CN)c1.CCN(CC)CC.O=Cc1ccc(-c2nccs2)cc1>>CC(C)(C)OC(=O)COc1cccc(CNCc2ccc(-c3nccs3)cc2)c1",
        "output": "683"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.CCO.COc1ccc(F)cc1OC.ClCCl>>Oc1ccc(F)cc1O",
        "output": "19"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.ClCCl.O=Cc1cc(OCc2ccccc2)ccc1O.[Br-].[Li]CCCC>>C=Cc1cc(OCc2ccccc2)ccc1O",
        "output": "649"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCC(NC(=O)c1c(Cl)cccc1Cl)C(=O)OC.CC(C)CN(c1ccc(I)cc1)c1ncccn1>>COC(=O)C(C/C=C/c1ccc(N(CC(C)C)c2ncccn2)cc1)NC(=O)c1c(Cl)cccc1Cl",
        "output": "725"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)c1ccc(C(=O)Cl)cc1.CCN(CC)CC.COc1ncc(B2OC(C)(C)C(C)(C)O2)cc1N.ClCCl>>COc1ncc(B2OC(C)(C)C(C)(C)O2)cc1NC(=O)c1ccc(C(C)(C)C)cc1",
        "output": "501"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)c1cc2c(ccc3cnc(Nc4cccc(S(N)(=O)=O)c4)nc32)s1.ClCCl.O.O=C(O)C(F)(F)F>>NS(=O)(=O)c1cccc(Nc2ncc3ccc4sc(C(=O)O)cc4c3n2)c1",
        "output": "569"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCOC(=O)N1CCC(Nc2ccc(Cl)cc2)CC1.COc1ccc(CC(=O)Cl)cc1.c1ccccc1>>CCOC(=O)N1CCC(N(C(=O)Cc2ccc(OC)cc2)c2ccc(Cl)cc2)CC1",
        "output": "160"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)[O-].ClCCl.O=[Cr](=O)([O-])Cl.OCCCCCCOc1ccc(-c2cccc(F)c2F)cc1.[Na+].c1cc[nH+]cc1>>O=CCCCCCOc1ccc(-c2cccc(F)c2F)cc1",
        "output": "142"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1ccc(S)cc1.CCO.Nc1cc(Cl)ccc1[N+](=O)[O-].[Na]>>CC(=O)Nc1ccc(Sc2ccc([N+](=O)[O-])c(N)c2)cc1",
        "output": "233"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C)C1(NC(=O)OCc2ccccc2)COC1.CO.[Na+].[OH-]>>CC(C(=O)O)C1(NC(=O)OCc2ccccc2)COC1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.NCC(F)(F)F.O=C(Cl)c1cc(Cl)nc(Cl)c1.O=C([O-])O.[Na+].c1ccncc1>>O=C(NCC(F)(F)F)c1cc(Cl)nc(Cl)c1",
        "output": "271"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCc2ccc(Nc3nc4c(-c5ccccc5OCC(F)F)cccn4n3)cc2CC1.O=C(O)C(F)(F)F>>FC(F)COc1ccccc1-c1cccn2nc(Nc3ccc4c(c3)CCNCC4)nc12",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCc1nc2ccc(N(C(=O)NC)C3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.O=C(O)C(F)(F)F>>CCCCc1nc2ccc(N(C(=O)NC)C3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1cccc(-c2c(-c3ccccc3)nnc3c(Cl)cccc23)c1.O=Cc1ccc2ccccc2c1>>Clc1cccc2c(-c3cccc(NCc4ccc5ccccc5c4)c3)c(-c3ccccc3)nnc12",
        "output": "359"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)CBr.O=C([O-])[O-].Oc1cccc2ccccc12.[K+].[K+]>>CCOC(=O)COc1cccc2ccccc12",
        "output": "123"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C(C)Cc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(CO)Cc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H](C(=O)O)C(C)(C)C.CCN(CC)CC.CCN=C=NCCCN(C)C.Cc1ncc2n1C(=O)N(CCC1CCNCC1)C2.ClCCl.On1nnc2ccccc21>>Cc1ncc2n1C(=O)N(CCC1CCN(C(=O)[C@H](NC(=O)OC(C)(C)C)C(C)(C)C)CC1)C2",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Nc1ccncc1.O.O=C(Cl)OCC(Cl)(Cl)Cl.c1ccncc1>>O=C(Nc1ccncc1)OCC(Cl)(Cl)Cl",
        "output": "102"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCC(N)(Cc1ccccc1)C(=O)OC.CO.O.[Na+].[OH-]>>CCC(N)(Cc1ccccc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.O=[N+]([O-])c1cc(F)c(F)cc1F.Oc1ccccn1.Oc1ccnc(Cl)c1.[H-].[Na+]>>O=[N+]([O-])c1cc(F)c(Oc2ccnc(Cl)c2)cc1F",
        "output": "564"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCOC(=O)Cc1ccc(Nc2cc(C3CC3)nc(-c3cccc(Cl)c3)n2)nc1.Cl.O.O.[Li+].[OH-]>>O=C(O)Cc1ccc(Nc2cc(C3CC3)nc(-c3cccc(Cl)c3)n2)nc1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCNCC.ClCCl.O=C(O)C(F)(F)F.O=CCc1c[nH]c2cc(F)c(F)cc12.[Na+]>>CCN(CC)CCc1c[nH]c2cc(F)c(F)cc12",
        "output": "484"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1cccc(Br)n1.C1CCOC1.Cc1cccc(-n2nnn(C)c2=O)c1CO.O.[H-].[Na+]>>Cc1cccc(-n2nnn(C)c2=O)c1COc1cccc(Br)n1",
        "output": "551"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCCC.Fc1ccc(-c2cc(N3CCNCC3)ccn2)c(F)c1.O=C(Nc1cccnn1)OCC(Cl)(Cl)Cl>>O=C(Nc1cccnn1)N1CCN(c2ccnc(-c3ccc(F)cc3F)c2)CC1",
        "output": "980"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)C(=O)Cl.ClCCl.Nc1ccc(Cl)cn1>>CC(C)(C)C(=O)Nc1ccc(Cl)cn1",
        "output": "332"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)CC1Cc2cc(-c3ccc(OC)c(CC)c3)ccc2C1=O.CO.Cl.ClCCl.O.[Na+].[OH-]>>CCc1cc(-c2ccc3c(c2)CC(CC(=O)O)C3=O)ccc1OC",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCc1cc(NC(=O)Oc2ccccc2)c(OC)nc1C.CSc1ccccc1N1CCNCC1>>CCc1cc(NC(=O)N2CCN(c3ccccc3SC)CC2)c(OC)nc1C",
        "output": "525"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCc1cc(C(F)(F)F)ccc1C1(O)CCCCC1.CI.[H-].[Na+]>>COC1(c2ccc(C(F)(F)F)cc2CO[Si](C)(C)C(C)(C)C)CCCCC1",
        "output": "140"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.COC(=O)Cl.Nc1cccc([N+](=O)[O-])c1.O.O=C([O-])O.[Na+]>>COC(=O)Nc1cccc([N+](=O)[O-])c1",
        "output": "102"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O.Clc1nc(Cl)nc(Cl)n1.Nc1ccc(C(F)(F)F)cc1>>FC(F)(F)c1ccc(Nc2nc(Cl)nc(Cl)n2)cc1",
        "output": "592"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)c1ccc(S(=O)(=O)Cl)cc1.CCC(=O)NCC1Cc2ccc(N)cc2C1.ClCCl.c1ccncc1>>CCC(=O)NCC1Cc2ccc(NS(=O)(=O)c3ccc(C(C)C)cc3)cc2C1",
        "output": "68"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COc1cc(F)ccc1C(C)=O.C[S-].Cl.[Na+]>>COc1cc(SC)ccc1C(C)=O",
        "output": "503"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc(-c2noc(C3CC3)n2)cc1Cl.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>Clc1cc(-c2noc(C3CC3)n2)ccc1CBr",
        "output": "29"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCCCC1.C1CCOC1.CCOC(=O)Nc1ccccc1OC(F)(F)F.II>>CCOC(=O)Nc1c(I)cccc1OC(F)(F)F",
        "output": "372"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COCCCn1nnnc1-c1cc(-c2cccc(C(=O)OC)c2)c(OCc2ccccc2)cc1OCc1ccccc1.Cl.O.[Li+].[OH-]>>COCCCn1nnnc1-c1cc(-c2cccc(C(=O)O)c2)c(OCc2ccccc2)cc1OCc1ccccc1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(CC2(CCc3ccc(N)cc3)OCCO2)OCCO1.CCN=C=NCCCN(C)C.ClCCl.O=C(O)CCOCCOCCOCCOCCOCCOCCC(=O)O>>CC1(CC2(CCc3ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCC(=O)O)cc3)OCCO2)OCCO1",
        "output": "365"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.N#Cc1cc(N)ccc1N1CCN(C(c2ccccc2)c2cccnc2)CC1.O=C(Cl)C1CC1>>N#Cc1cc(NC(=O)C2CC2)ccc1N1CCN(C(c2ccccc2)c2cccnc2)CC1",
        "output": "9"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cl.Cn1c(-c2cncc(CNS(=O)(=O)CCN3C(=O)c4ccccc4C3=O)c2)c(C#N)c2ccc(Cl)cc21.NN>>Cn1c(-c2cncc(CNS(=O)(=O)CCN)c2)c(C#N)c2ccc(Cl)cc21",
        "output": "242"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.N[C@@H]1C[C@H]2CN(c3ccc(OC(F)(F)F)cc3)C(=O)N2C1.O.O=C(Cl)c1ccccc1Cl>>O=C(N[C@@H]1C[C@H]2CN(c3ccc(OC(F)(F)F)cc3)C(=O)N2C1)c1ccccc1Cl",
        "output": "271"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.[Pd].c1ccc(COc2ccc3nc(Oc4ccccc4)ccc3c2)cc1>>Oc1ccc2nc(Oc3ccccc3)ccc2c1",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1(C)C.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.CCOC(C)=O.ClCCl.Nc1ccc(C(=O)O)cc1F>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(N)c(F)c2)CC1(C)C",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCC1CO1.CC(C)c1cc(C=Cc2ccccc2O)on1.[H-].[Na+]>>CC(C)c1cc(C=Cc2ccccc2OCC2CO2)on1",
        "output": "18"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(CCn1cnc(I)c1)NC(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CC(C)(N)CCn1cnc(I)c1",
        "output": "538"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.CON(C)C(=O)C(CC(=O)OC(C)(C)C)NS(=O)(=O)c1ccc(NC(C)=O)cc1OCc1ccccc1.[H][H].[Pd]>>CON(C)C(=O)C(CC(=O)OC(C)(C)C)NS(=O)(=O)c1ccc(NC(C)=O)cc1O",
        "output": "23"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1c(C)noc1-c1ccc(Br)cc1.Cl.O.[Li+].[OH-]>>Cc1noc(-c2ccc(Br)cc2)c1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COc1ccc(C(=O)O)cc1C(=O)O.O=S(=O)(O)O>>COC(=O)c1cc(C(=O)O)ccc1OC",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.CCOCCBr.Cc1nc2c(N(Cc3ccccc3)Cc3ccccc3)nc(Cl)c(C)c2[nH]1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CCOCCn1c(C)nc2c(N(Cc3ccccc3)Cc3ccccc3)nc(Cl)c(C)c21",
        "output": "495"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)C(c1ccccc1)c1ccccc1.NN.O>>NNC(=O)C(c1ccccc1)c1ccccc1",
        "output": "130"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.Clc1nc(Cl)c2ncn(C3CCCC3)c2n1.NCCCN1CCOCC1>>Clc1nc(NCCCN2CCOCC2)c2ncn(C3CCCC3)c2n1",
        "output": "145"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.ClCCl.Cn1nccc1[C@H]1C[C@H](OCc2ccccc2)C[C@@H]1O.O.O=C(Cl)c1ccccc1>>Cn1nccc1[C@H]1C[C@H](OCc2ccccc2)C[C@@H]1OC(=O)c1ccccc1",
        "output": "51"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O.Cc1sc(N2CCNCC2)nc1C(F)(F)F>>Cc1sc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3OC(C)C)CC2)nc1C(F)(F)F",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)Cc1ccc2c(n1)CCCC2.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Mg+2].[Na+].[OH-]>>OCCc1ccc2c(n1)CCCC2",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.C=CC(=O)Cl.CC(C)(C)OC(=O)N1CCC(S(=O)(=O)c2ccc(N)cc2)CC1.CCN(C(C)C)C(C)C>>C=CC(=O)Nc1ccc(S(=O)(=O)C2CCN(C(=O)OC(C)(C)C)CC2)cc1",
        "output": "10"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)N.CC1=C(c2ccccc2)C(=O)N(C(C)(C)C(=O)O)CO1.O.O=C(n1ccnc1)n1ccnc1>>CC1=C(c2ccccc2)C(=O)N(C(C)(C)C(=O)NC(C)C)CO1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C)NC.O=C(O)c1cc(-c2ccccc2Cl)nc2ccccc12.O=S(Cl)Cl>>CCC(C)N(C)C(=O)c1cc(-c2ccccc2Cl)nc2ccccc12",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1nc(N2CCOCC2)nc(C)c1[N+](=O)[O-].O=C[O-].[NH4+].[Pd]>>Cc1nc(N2CCOCC2)nc(C)c1N",
        "output": "660"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CCCCCCCCCC(=O)Cl.CC(O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4N(C)C(=O)CC[C@]4(C)[C@H]3CC[C@]12C.ClCCl.c1ccncc1>>C=CCCCCCCCCC(=O)OC(C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4N(C)C(=O)CC[C@]4(C)[C@H]3CC[C@]12C",
        "output": "126"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.CS(=O)(=O)c1ccc(-n2ncc3c(OC4CCNCC4)ncnc32)c(F)c1.O=C(CBr)c1ccc(OC(F)(F)F)cc1.O=C([O-])[O-].[K+].[K+]>>CS(=O)(=O)c1ccc(-n2ncc3c(OC4CCN(CC(=O)c5ccc(OC(F)(F)F)cc5)CC4)ncnc32)c(F)c1",
        "output": "413"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)Cn1nc(-c2ccc(F)cc2F)cc(C(=O)O)c1=O.Cc1c(-c2ccc(F)c(F)c2)nn(CC(C)C)c(=O)c1N1CCN(C(=O)OC(C)(C)C)CC1>>CC(C)Cn1nc(-c2ccc(F)cc2F)cc(CO)c1=O",
        "output": "293"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.COC(=O)Cc1ccc(O)cc1.ClCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)Cc1ccc(OCc2ccccc2)cc1",
        "output": "49"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCS.COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2ccc(OC3CCN(Cc4ccccc4)C3)cc2)cc1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(c1ccc(OC2CCN(Cc3ccccc3)C2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12",
        "output": "20"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCOCC.ClCCl.O.O=C([O-])O.O=S([O-])([O-])=S.OCC(F)c1ccccc1.[Na+].[Na+].[Na+]>>O=CC(F)c1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc(NCC(C)C)c([N+](=O)[O-])c(Oc2ccccc2)n1.Cc1ccccc1.[H][H].[Pt]>>Cc1cc(NCC(C)C)c(N)c(Oc2ccccc2)n1",
        "output": "269"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)CCCN.ClC(Cl)Cl.O.O=C(Cl)N1CCC(Oc2cccc(Cl)c2)C1.O=C([O-])[O-].[Na+].[Na+]>>CN(C)CCCNC(=O)N1CCC(Oc2cccc(Cl)c2)C1",
        "output": "454"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Cc2nn(C(=O)OC(C)(C)C)c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21.CCOC(C)=O.Cl>>CC(C)N(Cc1ccccc1)C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)c2nnc(-c3ccccc3)n2-c2ccccc21",
        "output": "896"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(CCl)N1CCOCC1.Oc1cccc(-n2nc(-c3ccc(F)cc3)c3cccnc32)c1>>O=C(COc1cccc(-n2nc(-c3ccc(F)cc3)c3cccnc32)c1)N1CCOCC1",
        "output": "458"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCSc1ccc([N+](=O)[O-])c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1.CO.[Pd]>>CCSc1ccc(N)c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCOC(C)=O.Cl.Nc1cccc(OC(F)(F)F)c1.O=Cc1ccc(C(=O)O)cc1>>O=Cc1ccc(C(=O)Nc2cccc(OC(F)(F)F)c2)cc1",
        "output": "50"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.O=C([O-])[O-].Oc1cc(F)c(Br)cc1F.[K+].[K+]>>COc1cc(F)c(Br)cc1F",
        "output": "62"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.COC(=O)c1c(-c2ccc(F)cc2)cc(C)nc1C.[H-].[K+].[OH-]>>Cc1cc(-c2ccc(F)cc2)c(CO)c(C)n1",
        "output": "522"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOc1c(C(C)=O)cc(C)c(C#N)c1-c1ccc(C(=O)N(C)C)nc1.CO.[BH4-].[Na+]>>CCOc1c(C(C)O)cc(C)c(C#N)c1-c1ccc(C(=O)N(C)C)nc1",
        "output": "24"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)c1ccc([C@@H]2C[C@H]2C(=O)O)cc1.CC(C)C[C@@H]1NC[C@H](C2CCCC2)NC1=O.CC(C)C[C@H]1CN(C(=O)[C@@H]2C[C@H]2c2ccccc2)[C@@H](CC(C)C)C(=O)N1>>CC(C)C[C@H]1C(=O)N[C@@H](C2CCCC2)CN1C(=O)[C@@H]1C[C@H]1c1ccc(C(C)(C)C)cc1",
        "output": "297"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc2c(Cl)ncnc2cc1OCC1CCN(C)CC1.Cc1nc2ccc(O)cc2[nH]1>>COc1cc2c(Oc3ccc4nc(C)[nH]c4c3)ncnc2cc1OCC1CCN(C)CC1",
        "output": "668"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc(Br)c(CC(F)(F)F)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1ccc(Br)c(CC(F)(F)F)c1",
        "output": "444"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.ClCCl.OCCC1(Br)CC1.c1ccncc1>>CC(C)(C)[Si](C)(C)OCCC1(Br)CC1",
        "output": "839"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C(CC(C)C)c1ccc(OCc2ccccc2)cc1.CO.[Pd]>>CCOC(=O)C(CC(C)C)c1ccc(O)cc1",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.C=[N+]=[N-].CC(=O)O.Cc1ccccc1Nc1c(C(=O)O)cnc(Cl)c1C>>COC(=O)c1cnc(Cl)c(C)c1Nc1ccccc1C",
        "output": "60"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COc1cc2c(c(OC)c1OC)-c1ccc(NC(=O)[C@H](C)NC(=O)OCc3ccccc3)cc1C(NC(C)=O)CC2.[Pd]>>COc1cc2c(c(OC)c1OC)-c1ccc(NC(=O)[C@H](C)N)cc1C(NC(C)=O)CC2",
        "output": "128"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.COc1cc(N)ccc1N1CCN(C)CC1.N#Cc1cc(-c2ncnc(Cl)n2)ccc1OC1CCOCC1>>COc1cc(Nc2ncnc(-c3ccc(OC4CCOCC4)c(C#N)c3)n2)ccc1N1CCN(C)CC1",
        "output": "592"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrBr.CC(=O)O.COC(=O)Cc1cc(O)c(O)cc1C=O.O>>COC(=O)Cc1c(C=O)cc(O)c(O)c1Br",
        "output": "98"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cc1nn(C2CCCCO2)c2nc(-c3ccc(O)cc3)cc(CN3CC(C)(C)N(Cc4ccccc4)CC3(C)C)c12>>Cc1nn(C2CCCCO2)c2nc(-c3ccc(O)cc3)cc(CN3CC(C)(C)NCC3(C)C)c12",
        "output": "84"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)Cl.Cc1ccc(N)c(C#N)c1.O=C([O-])[O-].[Na+].[Na+]>>COC(=O)Nc1ccc(C)cc1C#N",
        "output": "102"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClCCl.N#Cc1sc2cc(N)ccc2c1Cl.O=C(Cl)OCc1ccccc1.c1ccncc1>>N#Cc1sc2cc(NC(=O)OCc3ccccc3)ccc2c1Cl",
        "output": "509"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cc2nc(-c3ccccc3)cn2cc1Br.Cl.[K+].[OH-]>>O=C(O)c1cc2nc(-c3ccccc3)cn2cc1Br",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(CO)CCCC1(C)CCCC2(CO1)OCCO2.ClCCl.[Cr+6].[O-2].[O-2].[O-2].c1ccncc1>>CC(C=O)CCCC1(C)CCCC2(CO1)OCCO2",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.O.O=C(OCc1ccccc1)c1cc(OCc2ccccc2)c(OCc2ccccc2)cn1.[K+].[OH-]>>O=C(O)c1cc(OCc2ccccc2)c(OCc2ccccc2)cn1",
        "output": "291"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCCCCCCCCCCCCOCC(O)CO.CCN(CC)CC.ClC(c1ccccc1)(c1ccccc1)c1ccccc1.ClCCl>>CCCCCCCCCCCCCCCCCCOCC(O)COC(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "250"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1ccc(CC(C)=O)c(OC)c1.NCC(O)c1cccc(C(F)(F)F)c1>>COC(=O)c1ccc(CC(C)NCC(O)c2cccc(C(F)(F)F)c2)c(OC)c1",
        "output": "236"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)Nc1cc(Cl)c(C(F)(F)F)cc1N.Cc1cc(-c2cccc(C(=O)CC(=O)OC(C)(C)C)c2)on1>>Cc1cc(-c2cccc(C(=O)CC(=O)Nc3cc(C(F)(F)F)c(Cl)cc3NC(=O)OC(C)(C)C)c2)on1",
        "output": "929"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.COc1ccc(C)nc1.O.OO.[Mn+4].[O-2].[O-2]>>COc1ccc(C)[n+]([O-])c1",
        "output": "396"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCOc1ccc(Cl)cc1CC#N.CCO.O.[K+].[OH-]>>C=CCOc1ccc(Cl)cc1CC(=O)O",
        "output": "259"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COc1c(Cl)cc(C(=O)O)cc1I.Cc1ccccc1.O=S(Cl)Cl>>COc1c(Cl)cc(C(=O)Cl)cc1I",
        "output": "3"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1nn(-c2ccc(N)cc2)c(=O)o1.ClCCl.O=C(Cl)Cc1ccc(Cl)cc1.c1ccncc1>>COc1nn(-c2ccc(NC(=O)Cc3ccc(Cl)cc3)cc2)c(=O)o1",
        "output": "9"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCC(c2cc3c(-c4nc(NCC5CCNCC5)ccc4Cl)ccnc3[nH]2)CC1.Cl.On1nnc2ccccc21>>CC(=O)N1CCC(CNc2ccc(Cl)c(-c3ccnc4[nH]c(C5CCN(C)CC5)cc34)n2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.C=CCCO.CCOC(C)=O.Nc1cncc(Cl)n1.[H-].[Na+]>>C=CCCOc1cncc(N)n1",
        "output": "209"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)NC(C)C.CN(C)C=O.COc1cc(Br)c(C#N)nc1OC.O.O.O=S(=O)([O-])c1cccc(P(c2cccc(S(=O)(=O)[O-])c2)c2cccc(S(=O)(=O)[O-])c2)c1.OB(O)c1cccc(-c2ccccc2)c1.[Na+].[Na+].[Na+].[Pd+2]>>COc1cc(-c2cccc(-c3ccccc3)c2)c(C#N)nc1OC",
        "output": "833"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1ccccc1.C1COCCO1.CC(=O)N1c2ccccc2[C@H](N)[C@@H](C)[C@@H]1C(C)C.CC(C)(C)[O-].CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CC(=O)N1c2ccccc2[C@H](Nc2ccccc2)[C@@H](C)[C@@H]1C(C)C",
        "output": "932"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrBr.Cc1cccc(C2CC2)c1O.ClCCl>>Cc1cc(Br)cc(C2CC2)c1O",
        "output": "98"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CC2(CCN1)OCCO2.COc1cc(-c2cc(CCl)ccn2)cc(OC)c1OC>>COc1cc(-c2cc(CN3CCC4(CC3)OCCO4)ccn2)cc(OC)c1OC",
        "output": "156"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=C(O)c1cc(O)c(-c2ccccc2)c([N+](=O)[O-])c1.O=S(=O)(O)O>>CCOC(=O)c1cc(O)c(-c2ccccc2)c([N+](=O)[O-])c1",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)C[C@H](NC(=O)CNC(=O)CCCCNc1nc2ccccc2[nH]1)c1cccnc1.Cl>>O=C(O)C[C@H](NC(=O)CNC(=O)CCCCNc1nc2ccccc2[nH]1)c1cccnc1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CN(C)C=O.CN1CCCC1.CNC1CNC1.Cl.Cl.Nc1nc(-n2cc(C(=O)O)c(=O)c3cc(F)c(F)c(F)c32)c(F)cc1F>>CNC1CN(c2c(F)cc3c(=O)c(C(=O)O)cn(-c4nc(N)c(F)cc4F)c3c2F)C1",
        "output": "676"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)C(Cc1ccc(OCCC2c3ccccc3Oc3ccccc32)cc1)OCC.[Na+].[OH-]>>CCOC(Cc1ccc(OCCC2c3ccccc3Oc3ccccc32)cc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CC(=O)N1CCNCC1.CCOCC.O=C([O-])[O-].OCCCBr.[K+].[K+]>>CC(=O)N1CCN(CCCO)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO[C@H]1CN(c2nccs2)C[C@H]1Nc1nc(CC)c(-c2ccc(Cl)cc2Cl)nc1CC.CCO[C@H]1CNC[C@H]1Nc1nc(CC)c(-c2ccc(OC)cc2Cl)nc1CC.COc1ccnc(Cl)n1>>CCO[C@H]1CN(c2nccc(OC)n2)C[C@H]1Nc1nc(CC)c(-c2ccc(OC)cc2Cl)nc1CC",
        "output": "36"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.Nc1cncc(-c2cc(NCc3ccccc3)c3c(Cl)ccn3n2)c1>>CS(=O)(=O)Nc1cncc(-c2cc(NCc3ccccc3)c3c(Cl)ccn3n2)c1",
        "output": "812"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.Cc1cc(C(=O)O)[nH]c1C=C1C(=O)Nc2ccccc21.NCCCCCCO>>Cc1cc(C(=O)NCCCCCCO)[nH]c1C=C1C(=O)Nc2ccccc21",
        "output": "137"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCC.Cl.O=C(O)C(Cl)CO.OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>O=C(OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(Cl)CO",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C1CCc2[nH]c3ccc(N)cc3c2C1.Cc1ccc(C(=O)O)o1>>Cc1ccc(C(=O)Nc2ccc3[nH]c4c(c3c2)CC(N(C)C)CC4)o1",
        "output": "860"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)=O.CCN(CC)C(=O)C1CN2CCC1C(NCc1cc(OC)ccc1OC)C2C(c1ccccc1)c1ccccc1.CS(=O)(=O)O.O=S(=O)([O-])[O-].[Na+].[Na+]>>CCN(CC)CC1CN2CCC1C(NCc1cc(OC)ccc1OC)C2C(c1ccccc1)c1ccccc1",
        "output": "112"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OCC(=O)N1CCN(CCNC(=O)Cc2c(C)[nH]c(/C=C3\\C(=O)Nc4ccc(S(=O)(=O)Cc5c(Cl)cccc5Cl)cc43)c2C)CC1.CO.O.O=C([O-])[O-].[K+].[K+]>>Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1CC(=O)NCCN1CCN(C(=O)CO)CC1",
        "output": "687"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CCOC(=O)c1cc(Cl)nc(Cl)c1C.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>CCOC(=O)c1cc(Cl)nc(Cl)c1CBr",
        "output": "625"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)NC[C@H]1CN(c2ccc(N3CCC(=O)CC3)c(F)c2)C(=O)O1.CN.CO.Cl.ClCCl.O=C([O-])O.[H][H].[Na+].[Pd]>>CNC1CCN(c2ccc(N3C[C@H](CNC(C)=O)OC3=O)cc2F)CC1",
        "output": "236"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)c1cn2c(c(OCc3ccccc3)c1=O)C(=O)N(Cc1cccc(Cl)c1)CC2.O=C1c2c(OCc3ccccc3)c(=O)c(Br)cn2CCN1Cc1cccc(Cl)c1>>COC(=O)c1cn2c(c(O)c1=O)C(=O)N(Cc1cccc(Cl)c1)CC2",
        "output": "264"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)c1cccc(N)c1.O=C(O)c1cnn(-c2cccc(Cl)c2)c1C(F)(F)F>>CS(=O)(=O)c1cccc(NC(=O)c2cnn(-c3cccc(Cl)c3)c2C(F)(F)F)c1",
        "output": "851"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Clc1nc(Cl)nc(Cl)n1.NCc1ccncc1>>Clc1nc(Cl)nc(NCc2ccncc2)n1",
        "output": "578"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C#N)c1cccc(C(=O)O)c1.Nc1cccc(C#Cc2cnc(NCCCN3CCOCC3)nc2)c1>>CC(C#N)c1cccc(C(=O)Nc2cccc(C#Cc3cnc(NCCCN4CCOCC4)nc3)c2)c1",
        "output": "50"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)NC(=O)c1csc(Br)n1.Cl.O=C1OCc2ccccc2N1C1CCNCC1>>CC(C)NC(=O)c1csc(N2CCC(N3C(=O)OCc4ccccc43)CC2)n1",
        "output": "657"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.CC(=O)O.COc1cc([N+](=O)[O-])ccc1O.O>>COc1cc([N+](=O)[O-])cc(Br)c1O",
        "output": "98"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1cnc2nc(COc3ccccn3)cn2c1.OB(O)c1cccc(F)c1F>>Fc1cccc(-c2cnc3nc(COc4ccccn4)cn3c2)c1F",
        "output": "871"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCl.O=[Cr](=O)([O-])Cl.OC(Cc1ccccc1)c1ccc2c(c1)c(-c1ccc(F)cc1)nn2C1CCCCO1.c1cc[nH+]cc1>>O=C(Cc1ccccc1)c1ccc2c(c1)c(-c1ccc(F)cc1)nn2C1CCCCO1",
        "output": "32"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)C(N)c1cc2ccsc2s1.C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O>>COC(=O)C(NC(=O)[C@H](C)NC(=O)Cc1cc(F)cc(F)c1)c1cc2ccsc2s1",
        "output": "129"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC(C(=O)N2CC[C@@H](O)C2)C1.ClCCl.O=C(O)C(F)(F)F>>O=C(C1CNC1)N1CC[C@@H](O)C1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COCCN.C[Al](C)C.Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)O)cn1.O>>COCCNC(=O)c1ccc(OCc2c(-c3ccccc3)noc2C)nc1",
        "output": "674"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cnn(Cc2ccccc2)c(=O)c1Cl.Cl.O.[K+].[OH-]>>O=c1c(Cl)c(O)cnn1Cc1ccccc1",
        "output": "424"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C(=O)OCOc1ccc2c(c1)[C@@]13CCCC[C@H]1[C@@H](C2)N(C(=O)OCc1ccccc1)CC3.CCO.[Pd]>>CC(C)C(=O)OCOc1ccc2c(c1)[C@@]13CCCC[C@H]1[C@@H](C2)NCC3",
        "output": "428"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCS(=O)(=O)c1ccc(Cl)cc1Nn1cnc2cc(CN3CCN(C(=O)OC(C)(C)C)CC3)c(C(F)(F)F)cc2c1=O.CCS(=O)(=O)n1cccc1CN.Cl>>CCS(=O)(=O)c1ccc(Cl)cc1Nn1cnc2cc(CN3CCNCC3)c(C(F)(F)F)cc2c1=O",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1ccc(Br)c(C)n1.O.[K+]>>Cc1ccc(B2OC(C)(C)C(C)(C)O2)c(C)n1",
        "output": "943"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.Cc1ccc(O)cc1.ClCCCBr.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(OCCCCl)cc1",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COCC(=O)CC(=O)C1CC1.COCc1cc(C2CC2)nc(Nc2ccccc2)n1.ClCCl.N=C(N)Nc1ccccc1>>OCc1cc(C2CC2)nc(Nc2ccccc2)n1",
        "output": "423"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)c1ccncc1.ClCCl.N#Cc1nc(N[C@H](CCCO)C2CCC2)c2c(ncn2Cc2ccc(C(F)(F)F)cc2)n1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCC[C@@H](Nc1nc(C#N)nc2ncn(Cc3ccc(C(F)(F)F)cc3)c12)C1CCC1",
        "output": "193"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)Cc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2)cc1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)Cc1ccc(C2CCNCC2)cc1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCO.COC(=O)[C@@H]1CC[C@@H](Oc2cccnc2)CC1.NN.O>>NNC(=O)[C@@H]1CC[C@@H](Oc2cccnc2)CC1",
        "output": "130"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OCCOCn1cc(C)c(=O)[nH]c1=O.CO.CO[Na].Cl>>Cc1cn(COCCO)c(=O)[nH]c1=O",
        "output": "225"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.COC(=O)C1(CCCCBr)Sc2cc(OC)ccc2OCC1=O.O=C([O-])[O-].[I-].[K+].[K+].[K+].c1ccc(N2CCNCC2)cc1>>COC(=O)C1(CCCCN2CCN(c3ccccc3)CC2)Sc2cc(OC)ccc2OCC1=O",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C[C@H]1CCC[C@@H](C)N1CCO.Oc1ccc2cc(Br)ccc2c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C[C@H]1CCC[C@@H](C)N1CCOc1ccc2cc(Br)ccc2c1",
        "output": "550"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)c1ccc(C#N)cc1.N#Cc1cccc(C=O)c1>>N#Cc1ccc(C(=O)C=Cc2cccc(C#N)c2)cc1",
        "output": "295"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=Cn1cc(C(=O)OCC)cn1.CC(C)C[Al+]CC(C)C.CCOCC.CO.Cc1ccccc1.O.O.O.O.O=C([O-])C(O)C(O)C(=O)[O-].[H-].[K+].[Na+]>>C=Cn1cc(CO)cn1",
        "output": "471"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CN(Cc1ccc(C(F)(F)F)c(F)c1)C1CN(Cc2ccccc2)CC1c1cccc(Cl)c1.O=C(Cl)OCC(Cl)(Cl)Cl>>CN(Cc1ccc(C(F)(F)F)c(F)c1)C1CNCC1c1cccc(Cl)c1",
        "output": "84"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C(NCc1ccncc1)C1(CCCCBr)c2ccccc2-c2ccccc21.c1ccc2nc(N3CCNCC3)ccc2c1>>O=C(NCc1ccncc1)C1(CCCCN2CCN(c3ccc4ccccc4n3)CC2)c2ccccc2-c2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COc1ccc(CCl)cc1.O=C([O-])[O-].O=Cc1ccc(O)cc1.[K+].[K+]>>COc1ccc(COc2ccc(C=O)cc2)cc1",
        "output": "49"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CC(=O)OC(C)=O.N#CC(CO)c1ccccc1.O=S(=O)(O)O>>CC(=O)OCC(C#N)c1ccccc1",
        "output": "254"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)CCCN1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)c1nc2c(C(F)(F)F)cc(-c3ccoc3)cn2c1Cl>>CC1(C)CCCN1C(=O)c1nc2c(C(F)(F)F)cc(-c3ccoc3)cn2c1Cl",
        "output": "729"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1cc(N)n(-c2cnn(CCO)c2)n1.CCOC(C)=O.O=C(Cl)OCC(Cl)(Cl)Cl.[Na+].[OH-]>>CC(C)(C)c1cc(NC(=O)OCC(Cl)(Cl)Cl)n(-c2cnn(CCO)c2)n1",
        "output": "700"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN.N#Cc1ccc(F)cc1>>CCNc1ccc(C#N)cc1",
        "output": "572"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1nc2ccc(S(=O)(=O)Cl)cc2s1.ClCCl.Nc1ccc(F)c(Nc2ncccc2-c2ncnc3c2ncn3C2CCCCO2)c1F.c1ccncc1>>Cc1nc2ccc(S(=O)(=O)Nc3ccc(F)c(Nc4ncccc4-c4ncnc5c4ncn5C4CCCCO4)c3F)cc2s1",
        "output": "68"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)C=O.Cl.NCc1ccc([N+](=O)[O-])cc1>>CC(C)(C)OC(=O)NCc1ccc([N+](=O)[O-])cc1",
        "output": "686"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cc(-c2ccc(OC)cc2)nn(CC2CC2)c1=O.Cc1ccccc1C.NCc1ccccn1>>COc1ccc(-c2cc(C(=O)NCc3ccccn3)c(=O)n(CC3CC3)n2)cc1",
        "output": "498"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OCc1cncc(COc2cc3c(=O)c(Cc4cccnc4)cn4c5cc(Br)ccc5c(c2)c34)c1.CO.O.[Na+].[OH-]>>O=c1c(Cc2cccnc2)cn2c3cc(Br)ccc3c3cc(OCc4cncc(CO)c4)cc1c32",
        "output": "348"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C[C@H](N)c1cccc([N+](=O)[O-])c1.[H][H].[Pd]>>C[C@H](N)c1cccc(N)c1",
        "output": "71"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC[SiH](CC)CC.O=C(O)C(F)(F)F.O=C1N(Cc2ccccn2)c2ccc(Br)cc2C1(O)c1cc2c(cc1O)OCCO2>>O=C1C(c2cc3c(cc2O)OCCO3)c2cc(Br)ccc2N1Cc1ccccn1",
        "output": "964"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.CC(=O)[O-].CC(=O)[O-].Cc1ccccc1.O.O=Cc1ccc(Br)cc1.OB(O)C1CC1.[Pd+2]>>O=Cc1ccc(C2CC2)cc1",
        "output": "956"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCOCC1.Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)Cl)cc2s1.ClC(Cl)Cl.NCCc1cccs1>>Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)NCCc3cccs3)cc2s1",
        "output": "43"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CNC(=O)c1nc(-c2cccc(N)c2)cnc1N.O=C=NCc1ccccc1>>CNC(=O)c1nc(-c2cccc(NC(=O)NCc3ccccc3)c2)cnc1N",
        "output": "888"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O.COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccccc4)cc3)cc2C1=O.COc1ccccc1C(=O)Cl>>COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccccc4OC)cc3)cc2C1=O",
        "output": "11"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.O.O=C(/C=C/c1ccc(OC(F)(F)c2ccc(OCCCC(F)(F)F)cc2)cc1)OCCc1ccc([N+](=O)[O-])cc1[N+](=O)[O-].[Zn]>>Nc1ccc(CCOC(=O)/C=C/c2ccc(OC(F)(F)c3ccc(OCCCC(F)(F)F)cc3)cc2)c(N)c1",
        "output": "204"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CB1OC(C)(C)C(C)(C)O1.CC(=O)[O-].CC(=O)[O-].CCCCN(CCCC)CCCC.CCOC(C)=O.Cc1ccccc1.Cl.O=[N+]([O-])c1ccc(Br)cc1.[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC1(C)OB(/C=C/c2ccc([N+](=O)[O-])cc2)OC1(C)C",
        "output": "539"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.C[C@H](NC(=O)[C@H](C)N(C)C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)C(=O)OCc1ccccc1.[H][H].[Pd]>>C[C@H](NC(=O)[C@H](C)N(C)C(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.ClCCl.O.Oc1c(Cc2ccccc2)ccc2ccccc12>>CCOC(=O)Oc1c(Cc2ccccc2)ccc2ccccc12",
        "output": "261"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C)(C)Oc1ccc2cc[nH]c2c1.COC(=O)COc1ccc2c(c1)CCN2>>CCOC(=O)C(C)(C)Oc1ccc2c(c1)NCC2",
        "output": "672"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.Cc1ccc(S(=O)(=O)Cl)cc1.ClC(Cl)Cl.O=C1c2cc(F)ccc2-n2c1nc1cc(N3COC(CO)C3)ccc1c2=O>>Cc1ccc(S(=O)(=O)OCC2CN(c3ccc4c(=O)n5c(nc4c3)C(=O)c3cc(F)ccc3-5)CO2)cc1",
        "output": "197"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "B.C1CCOC1.CCOc1cccc(Cl)c1C#N.Cl.O.[H][H]>>CCOc1cccc(Cl)c1CN",
        "output": "175"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC(COc2ccc(C3=CCN(S(C)(=O)=O)CC3)cc2)CC1.ClCCl.O=C(O)C(F)(F)F.[Na+].[OH-]>>CS(=O)(=O)N1CC=C(c2ccc(OCC3CCNCC3)cc2)CC1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NC(C(=O)c1ccc(O)cc1)c1ccc(Cl)c(Cl)c1.OCC1CCOCC1>>CC(C)(C)OC(=O)NC(C(=O)c1ccc(OCC2CCOCC2)cc1)c1ccc(Cl)c(Cl)c1",
        "output": "478"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(N)c1ccccc1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl.O=C(O)c1cnc2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc2c1.On1nnc2ccccc21>>CC(C)(NC(=O)c1cnc2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc2c1)c1ccccc1",
        "output": "790"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(CO)c1ccc(-c2ccc(Br)cc2)cc1.CCN(C(C)C)C(C)C.CCOC(C)=O.COCCl.Cc1ccccc1>>COCOCC(C)(C)c1ccc(-c2ccc(Br)cc2)cc1",
        "output": "598"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(NC(=O)CCl)C1.CC(C)(C)[O-].O.Oc1ccc(F)c(F)c1.[K+]>>CC(C)(C)OC(=O)N1CCC(NC(=O)COc2ccc(F)c(F)c2)C1",
        "output": "458"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)NCCN.CC(=O)Nc1nc(C)c(-c2ccc(S(=O)(=O)Cl)s2)s1.CCN(C(C)C)C(C)C.CN(C)C=O.ClCCl>>CC(=O)NCCNS(=O)(=O)c1ccc(-c2sc(NC(C)=O)nc2C)s1",
        "output": "600"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.FC(F)(F)c1ccccc1CN1CCNCC1.O=CCCc1cc(-c2ccccc2)no1.[Na+]>>FC(F)(F)c1ccccc1CN1CCN(CCCc2cc(-c3ccccc3)no2)CC1",
        "output": "484"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCCC(c2ccccc2C(=O)O)C1.N>>CC(C)(C)OC(=O)N1CCCC(c2ccccc2C(N)=O)C1",
        "output": "358"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(COC(C)(C)C)ON.N#Cc1ccc(N2C(=O)N(c3ccc(C(=O)O)c(F)c3)[C@@H]3CCCC[C@H]32)cc1C(F)(F)F>>CC(COC(C)(C)C)ONC(=O)c1ccc(N2C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)[C@@H]3CCCC[C@H]32)cc1F",
        "output": "741"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1COCCO1.CCCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCCCCCC)CC(=O)NCCC(=O)O.ClCCl.N[C@@H](CCC(=O)OCc1ccccc1)C(=O)OCc1ccccc1>>CCCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCCCCCC)CC(=O)NCCC(=O)N[C@@H](CCC(=O)OCc1ccccc1)C(=O)OCc1ccccc1",
        "output": "132"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CI.COc1cc2[nH]c(=O)ccc2cc1Cl.C[Si](C)(C)[N-][Si](C)(C)C.Cc1ccccc1.O.[K+]>>COc1cc2c(ccc(=O)n2C)cc1Cl",
        "output": "191"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCCC.Cc1c(N)cccc1CO[Si](C)(C)C(C)(C)C.O=C1CCC(=O)N1Cl>>Cc1c(CO[Si](C)(C)C(C)(C)C)ccc(Cl)c1N",
        "output": "121"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCOc1cc([C@@H](CS(C)(=O)=O)N2Cc3c(Cl)ccc(NC(=O)CCl)c3C2=O)ccc1OC.CN1CCNCC1>>CCOc1cc([C@@H](CS(C)(=O)=O)N2Cc3c(Cl)ccc(NC(=O)CN4CCN(C)CC4)c3C2=O)ccc1OC",
        "output": "340"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)CC(=O)c1cccc(-c2cncnc2)c1.Cc1cc(N)c(NC(=O)OC(C)(C)C)cc1C(F)(F)F>>Cc1cc(NC(=O)CC(=O)c2cccc(-c3cncnc3)c2)c(NC(=O)OC(C)(C)C)cc1C(F)(F)F",
        "output": "929"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1cnc(C(F)(F)F)nc1.O.[Na+].[OH-]>>O=C(O)c1cnc(C(F)(F)F)nc1",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCN(CCCc2c(C=O)[nH]c3c2CCCC3)CC1.CNS(=O)(=O)c1ccc2c(c1)CC(=O)N2>>CNS(=O)(=O)c1ccc2c(c1)/C(=C/c1[nH]c3c(c1CCCN1CCN(C)CC1)CCCC3)C(=O)N2",
        "output": "911"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.CCOC(=O)CCCCC(=O)c1ccc(F)c2ccccc12.ClCCl.O=S([O-])[O-].[Na+].[Na+]>>CCOC(=O)CCCC(Br)C(=O)c1ccc(F)c2ccccc12",
        "output": "82"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N1c2ccc(N3CCOCC3)cc2[C@H](N)[C@@H](C)[C@@H]1C.CCN(C(C)C)C(C)C.CN1CCCC1=O.N#Cc1ccc(Cl)nc1>>CC(=O)N1c2ccc(N3CCOCC3)cc2[C@H](Nc2ccc(C#N)cn2)[C@@H](C)[C@@H]1C",
        "output": "612"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)c1cccc(C(C)C)c1N=C=O.CCCCCC.CCCCCCc1ccccc1N>>CCCCCCc1ccccc1NC(=O)Nc1c(C(C)C)cccc1C(C)C",
        "output": "473"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(Cn2cccn2)CC1.Cl>>c1cnn(CC2CCNCC2)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.N.Nc1cnccc1C(=O)O.O=C(n1ccnc1)n1ccnc1>>NC(=O)c1ccncc1N",
        "output": "358"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC1(C(=O)O)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.Cn1cnc2cc(-c3ccc(C(=O)N4CCNCC4)cc3)ccc21.F[P-](F)(F)(F)(F)F.O>>Cn1cnc2cc(-c3ccc(C(=O)N4CCN(C(=O)C5(NC(=O)OC(C)(C)C)CC5)CC4)cc3)ccc21",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC[SiH](CC)CC.O.O=C(O)C(F)(F)F.O=C1COc2ccc(C(=O)CCl)cc2N1>>O=C1COc2ccc(CCCl)cc2N1",
        "output": "92"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1ccc(-c2cc(F)ccc2O)nc1.[Li+].[OH-]>>O=C(O)c1ccc(-c2cc(F)ccc2O)nc1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CI.CN(C)C=O.Cn1nc(Br)cc1N1CCC[C@@H]1CO.O.[H-].[Na+]>>COC[C@H]1CCCN1c1cc(Br)nn1C",
        "output": "140"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)OB(c2ccc(CCN3CCOCC3)cc2)OC1(C)C.COCCOC.O=C(/C=C/c1ccn(S(=O)(=O)c2cccc(Br)c2)c1)NOC1CCCCO1.O=C([O-])[O-].[Na+].[Na+]>>O=C(/C=C/c1ccn(S(=O)(=O)c2cccc(-c3ccc(CCN4CCOCC4)cc3)c2)c1)NOC1CCCCO1",
        "output": "933"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COCCOCCO.O=C(O)c1ccccc1>>COCCOCCOC(=O)c1ccccc1",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.ClCCl.N#Cc1cc(C(=O)O)ccc1OC(F)(F)F.O=C(Cl)C(=O)Cl>>N#Cc1cc(C(=O)Cl)ccc1OC(F)(F)F",
        "output": "448"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCSC)cc1CC2CC.CO.O.O.[Li]O>>CCC1Cc2cc(OCCSC)c(OC)cc2-c2cc(=O)c(C(=O)O)cn21",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc(B(O)O)cc1.N#Cc1cc(Br)c2c(c1)cc1n2CCNC1=O>>Cc1ccc(-c2cc(C#N)cc3cc4n(c23)CCNC4=O)cc1",
        "output": "833"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCOC(=O)COc1cc(N)c(F)cc1Cl.CCN(CC)CC.Cc1ccccc1.O=C1OC(=O)C2=C1CCCC2>>CCCCCOC(=O)COc1cc(N2C(=O)C3=C(CCCC3)C2=O)c(F)cc1Cl",
        "output": "410"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(Br)c1ccc(C(=O)Cl)cc1.Cc1ccc(N)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1.ClCCl.c1ccncc1>>Cc1ccc(NC(=O)c2ccc(C(C)Br)cc2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1",
        "output": "11"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.C[C@H](N)C1CC1.Nc1nc(Cl)cc(Cl)n1>>C[C@H](Nc1cc(Cl)nc(N)n1)C1CC1",
        "output": "166"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)CCc1cccc(-n2nc(C(C)(C)C)cc2N)c1.ClCCl.O=C(O)c1ccc(Cl)cc1.O=S(Cl)Cl>>CCOC(=O)CCc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)c2ccc(Cl)cc2)c1",
        "output": "917"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)c1c(C)nc2sc3c(c2c1Cl)CCCC3.ClCCl.[H-]>>Cc1nc2sc3c(c2c(Cl)c1CO)CCCC3",
        "output": "383"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CC1(c2ccc(O)cc2)COC1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)CC1(c2ccc(OS(=O)(=O)C(F)(F)F)cc2)COC1",
        "output": "731"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccccc1.O.O=P(Cl)(Cl)Cl.Oc1cc(C(F)(F)F)ncn1.c1ccc2ncccc2c1>>FC(F)(F)c1cc(Cl)ncn1",
        "output": "25"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)CCC1CCNCC1.Cl.O=C(O)c1cn2c3c(cccc13)CCC2>>COC(=O)CCC1CCN(C(=O)c2cn3c4c(cccc24)CCC3)CC1",
        "output": "256"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCC1CCN(Cc2cc(-c3ccccc3)no2)CC1.ClCCl.O=C(O)C(F)(F)F>>NCC1CCN(Cc2cc(-c3ccccc3)no2)CC1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)CCCCC(=O)N1CCOCC1.O.[Na+].[OH-]>>O=C(O)CCCCC(=O)N1CCOCC1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2C=O)c1.C[C@H](N)[C@H](O)c1ccccc1.ClCCl.O=C([O-])O.[Na+].[Na+]>>COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CN[C@@H](C)[C@H](O)c2ccccc2)c1",
        "output": "468"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1c([N+](=O)[O-])ccc(C(=O)O)c1F.COc1cc(CO)c(F)cc1[N+](=O)[O-]>>COc1c([N+](=O)[O-])ccc(CO)c1F",
        "output": "72"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCNCC.CO.O=C1Cc2ccccc2C1.[B-]C#N.[Na+]>>CCN(CC)C1Cc2ccccc2C1",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1CCCNC1.O=Cc1cccc(Br)n1>>CC1CCCN(Cc2cccc(Br)n2)C1",
        "output": "829"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1CCCC1=O.COC(=O)c1ccc2c(c1)c(=O)[nH]c1nccc(Cl)c12.Cl.Nc1ccc(NC(=O)c2ccccc2)cc1.O>>COC(=O)c1ccc2c(c1)c(=O)[nH]c1nccc(Nc3ccc(NC(=O)c4ccccc4)cc3)c12",
        "output": "922"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc2c(c1)CNCC2.C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC>>CC(C)(C)OC(=O)N1CCc2ccc(Br)cc2C1",
        "output": "867"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)O.COc1cc2ncc(C#N)c(Cl)c2cc1OC.Cl.Cl.Nc1ccc(O)c(Cl)c1.O.O=C([O-])[O-].[Na+].[Na+].c1ccncc1>>COc1cc2ncc(C#N)c(Nc3ccc(O)c(Cl)c3)c2cc1OC",
        "output": "115"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCS(=O)(=O)c1ccc(OCC[C@@H]2C[C@@H]2C2CCNCC2)cc1F.ClC(Cl)Cl.N#CBr.O=C([O-])[O-].[K+].[K+]>>CCS(=O)(=O)c1ccc(OCC[C@@H]2C[C@@H]2C2CCN(C#N)CC2)cc1F",
        "output": "532"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCCCN.Cc1ccccc1.O=C([O-])[O-].O=CO.[K+].[K+]>>CCOCCCNC=O",
        "output": "370"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1ccccc1.C1COCCO1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].OB(O)c1ccc(Cl)nc1.[K+].[K+].[K+].[Pd].[Pd]>>Clc1ccc(-c2ccccc2)cn1",
        "output": "899"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(C)=O.Cc1ccc(Cl)cc1-c1cc(-c2cc(N)ncn2)cn1C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F.[NH4+].[OH-]>>Cc1ccc(Cl)cc1-c1cc(-c2cc(N)ncn2)c[nH]1",
        "output": "848"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CCN(CC)CC.COC(=O)/C=C/c1cnc(Cl)cn1.C[C@@H](N)CN(C)Cc1ccccc1.O=C([O-])O.[Na+]>>COC(=O)/C=C/c1cnc(N[C@H](C)CN(C)Cc2ccccc2)cn1",
        "output": "148"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCI.CN(C)C=O.COCCOC.NC1=NC(c2cccc(Br)c2)(c2c[nH]c(=O)c(C(F)F)c2)c2cccc(F)c21.O=C([O-])[O-].[H-].[K+].[K+].[Na+]>>CCn1cc(C2(c3cccc(Br)c3)N=C(N)c3c(F)cccc32)cc(C(F)F)c1=O",
        "output": "302"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COc1cccnc1Cl.C[O-].[Na+]>>COc1cccnc1OC",
        "output": "433"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(NC1CCNCC1)c1nc2ccccc2c(=O)n1C.CCN(CC)CC.COc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O>>COc1ccc(S(=O)(=O)N2CCC(NC(C)c3nc4ccccc4c(=O)n3C)CC2)cc1",
        "output": "99"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1.O.O.[Li+].[OH-]>>O=C(O)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.Cl.O.OCc1c(F)c(F)c(CBr)c(F)c1F.[Na]>>CC(C)OCc1c(F)c(F)c(CO)c(F)c1F",
        "output": "464"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NC1CCCc2ccc(Cl)nc21.O=C(O)c1cnccn1.O=C([O-])O.[Na+]>>O=C(NC1CCCc2ccc(Cl)nc21)c1cnccn1",
        "output": "697"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.ClCCl.Nc1ccc(-n2ccnc2-c2ccncc2)cc1.O=C=Nc1cc(C(F)(F)F)ccc1F>>O=C(Nc1ccc(-n2ccnc2-c2ccncc2)cc1)Nc1cc(C(F)(F)F)ccc1F",
        "output": "473"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(CCCOc1cc(F)c(-c2c(O)nc(-c3cnccn3)nc2C2CCCCCC2)c(F)c1)C(=O)OC(C)(C)C.Cc1cccc(C)n1.O=P(Cl)(Cl)Cl>>CN(CCCOc1cc(F)c(-c2c(Cl)nc(-c3cnccn3)nc2C2CCCCCC2)c(F)c1)C(=O)OC(C)(C)C",
        "output": "25"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(=O)Nc1cnc(NCC2CCCCC2)c(CC(=O)O)c1.CCOC(C)=O.CO.Cl>>COC(=O)Cc1cc(NC(=O)C(C)(C)C)cnc1NCC1CCCCC1",
        "output": "195"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(S(=O)(=O)Cc2nc(-c3ccc(C(=O)O)cc3)oc2C)cc1.NCc1cnccn1.O=C(Cl)C(=O)Cl>>Cc1ccc(S(=O)(=O)Cc2nc(-c3ccc(C(=O)NCc4cnccn4)cc3)oc2C)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CCCC(=O)CCC.CCN(CC)CC.Cl.NCCc1ccc(C(F)(F)F)cc1Br.O.O=C([O-])O.[Na+].[Na+]>>CCCC(CCC)NCCc1ccc(C(F)(F)F)cc1Br",
        "output": "236"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.CCCc1c(O)ccc(C(C)=O)c1OCCCC(=O)OCC.CCCc1c(SCCCBr)ccc(C(C)=O)c1O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CCCc1c(SCCCOc2ccc(C(C)=O)c(OCCCC(=O)OCC)c2CCC)ccc(C(C)=O)c1O",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)CCN.CCCC(=O)Cl.CCN(CC)CC.Cl.Cl.ClCCl.O=C([O-])O.[Na+]>>CCCC(=O)NCCC(=O)OC(C)(C)C",
        "output": "45"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CO)C(=O)O.CC(C)(C)c1ccc(N)c(N)c1.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.CN(C)C=O.F[P-](F)(F)(F)(F)F.O>>CC(C)(C)OC(=O)N[C@@H](CO)c1nc2cc(C(C)(C)C)ccc2[nH]1",
        "output": "512"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)[O-].CCOC(C)=O.Clc1ccc(CCCCn2cncn2)nn1.OCc1coc(C=Cc2ccc(Cl)cc2)n1.[Cl-].[NH4+].[Na+]>>Clc1ccc(/C=C/c2nc(COc3ccc(CCCCn4cncn4)nn3)co2)cc1",
        "output": "407"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCN(CC)CCCNc1nc(-c2cc(C(=O)O)ccc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1.CCSCCN.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F>>CCSCCNC(=O)c1ccc(C)c(-c2nc(NCCCN(CC)CC)nc3c2ccc(=O)n3-c2c(F)cccc2F)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrBr.CC(=O)O.COC(=O)c1sc(-c2ccc(OC)cc2)c(C)c1C>>COC(=O)c1sc(-c2ccc(OC)c(Br)c2)c(C)c1C",
        "output": "98"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.CC(O)(C(=O)O)C(F)(F)F.N#Cc1ccc(N)cc1Sc1ccccc1.O.O=S(Cl)Cl>>CC(O)(C(=O)Nc1ccc(C#N)c(Sc2ccccc2)c1)C(F)(F)F",
        "output": "365"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CI.CN(C)C=O.N#Cc1ccc(NC2CCC(n3cncn3)C2)cc1C(F)(F)F.[H-].[Na+]>>CN(c1ccc(C#N)c(C(F)(F)F)c1)C1CCC(n2cncn2)C1",
        "output": "377"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.CNCCOc1cc(C)ccc1C(C)C.COc1c(C)c(C)c(O)c(C)c1CCl>>COc1c(C)c(C)c(O)c(C)c1CN(C)CCOc1cc(C)ccc1C(C)C",
        "output": "156"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)(C)N.Fc1cc(F)c(F)nc1F>>CC(C)(C)Nc1nc(F)c(F)cc1F",
        "output": "810"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Clc1cc(-n2cccn2)ncn1.Oc1ccccc1.c1ccccc1>>c1ccc(Oc2cc(-n3cccn3)ncn2)cc1",
        "output": "668"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C[C@@H](N)c1cccc(N2CCN(C(=O)OCc3ccccc3)CC2)c1.Cn1c(=O)c(O)c(C(=O)Cl)c2ccccc21>>C[C@@H](NC(=O)c1c(O)c(=O)n(C)c2ccccc12)c1cccc(N2CCN(C(=O)OCc3ccccc3)CC2)c1",
        "output": "411"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.NCCCCCC(=O)O.O.O.O.O=C(Cl)c1ccccc1.[Cl-].[Na+].[Na+].[OH-]>>O=C(O)CCCCCNC(=O)c1ccccc1",
        "output": "271"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)C(Cc1ccc(OCC(=NOC)c2cccc(OC)c2)cc1)OCC.[Na+].[OH-]>>CCOC(Cc1ccc(OCC(=NOC)c2cccc(OC)c2)cc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOc1cc(C=O)ccc1O.COCCOCCl>>CCOc1cc(C=O)ccc1OCOCCOC",
        "output": "375"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCC[C@H](NC2CCCC2)C1.CCOC(C)=O.FC(F)(F)c1ccccc1CBr.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCC[C@H](N(Cc2ccccc2C(F)(F)F)C2CCCC2)C1",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cccc(Br)c1.O=C1CCC2(CC1)OCCO2>>Cc1cccc(C2(O)CCC3(CC2)OCCO3)c1",
        "output": "321"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.Cc1ccccc1N=C=O.ClCCl.Nc1ccc(CC(=O)O)cc1>>Cc1ccccc1NC(=O)Nc1ccc(CC(=O)O)cc1",
        "output": "473"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cl.ClCCl.Fc1ccc(N2N=C(C(F)(F)C(F)(F)F)CC2c2cccc(N3CCNCC3)c2)c(F)c1>>CS(=O)(=O)N1CCN(c2cccc(C3CC(C(F)(F)C(F)(F)F)=NN3c3ccc(F)cc3F)c2)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)C(C)(C)Cc1ccc(Br)cc1.[Na+].[OH-]>>CC(C)(Cc1ccc(Br)cc1)C(=O)O",
        "output": "361"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCOC(=O)Cl.Cl.O=C(O)C1CCNCC1.[Na+].[OH-]>>CCCCOC(=O)N1CCC(C(=O)O)CC1",
        "output": "219"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(C)=O.CN(C(=O)OC(C)(C)C)c1cc2ccn(-c3ccc([N+](=O)[O-])cc3)c(=O)c2cc1F.[Pd]>>CN(C(=O)OC(C)(C)C)c1cc2ccn(-c3ccc(N)cc3)c(=O)c2cc1F",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.NCC(O)CO.O.O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.[H][H].[Ni]>>OCC(O)CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO",
        "output": "426"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClC(Cl)Cl.O=S(Cl)Cl.O=c1[nH]c2cc(Cl)ccc2c(=O)n1CCO>>O=c1[nH]c2cc(Cl)ccc2c(=O)n1CCCl",
        "output": "96"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Cn1cc(C(=O)CC(c2ccc(S(C)(=O)=O)cc2)c2cc(Cl)ccc2Cl)ccc1=O.NO.O=C([O-])O.[Na+]>>Cn1cc(/C(CC(c2ccc(S(C)(=O)=O)cc2)c2cc(Cl)ccc2Cl)=N/O)ccc1=O",
        "output": "966"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C[S-].Cc1ccccc1.N#Cc1cc(-c2ccnc3c2cc(-c2ccc(N4CCOCC4)cc2)n3S(=O)(=O)c2ccccc2)ccc1F.O.[Na+]>>CSc1ccc(-c2ccnc3c2cc(-c2ccc(N4CCOCC4)cc2)n3S(=O)(=O)c2ccccc2)cc1C#N",
        "output": "503"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCC2=NCCCN2CC1.C1CCOC1.CC(C)Oc1cc(CCC(=O)O)n(Cc2ccc(Cl)cc2Cl)n1.NS(=O)(=O)Cc1ccccc1>>CC(C)Oc1cc(CCC(=O)NS(=O)(=O)Cc2ccccc2)n(Cc2ccc(Cl)cc2Cl)n1",
        "output": "644"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(S(=O)(=O)CC)c2)c1CCC(=O)OCC.[Na+].[OH-]>>CCS(=O)(=O)c1cc(OCCCCCCc2cccc(OCCCC(=O)O)c2CCC(=O)O)cc(-c2ccc(F)cc2)c1",
        "output": "255"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1CCNCC1.O=S(=O)(c1cccc2ccccc12)N1CCSCC1CCCl>>CC1CCN(CCC2CSCCN2S(=O)(=O)c2cccc3ccccc23)CC1",
        "output": "138"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.Cl.NCCO.O=[N+]([O-])c1cccc(Nc2cc(Cl)ncn2)c1>>O=[N+]([O-])c1cccc(Nc2cc(NCCO)ncn2)c1",
        "output": "166"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1N.Cl.F[B-](F)(F)F.O=C(O)c1cc2[nH]c(=O)cnc2s1>>Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1NC(=O)c1cc2[nH]c(=O)cnc2s1",
        "output": "822"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.NN.Nc1c(C(=O)O)cccc1[N+](=O)[O-].O.[Na+].[Ni].[OH-]>>Nc1cccc(C(=O)O)c1N",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](O)C1.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CC[C@@H](OS(=O)(=O)c2ccccc2[N+](=O)[O-])C1",
        "output": "197"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)CCc1ccc(Oc2ccc(C(C)(C)C(=O)NNC(=O)OC(C)(C)C)cc2)cc1.O.[Li+].[OH-]>>CC(C)(C)OC(=O)NNC(=O)C(C)(C)c1ccc(Oc2ccc(CCC(=O)O)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C1=Cc2cccc(/C=C/C(=O)OC(C)(C)C)c2OCC1.O=C(O)C(F)(F)F>>CCOC(=O)C1=Cc2cccc(/C=C/C(=O)O)c2OCC1",
        "output": "158"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCN(c2cc([N+](=O)[O-])cc(-c3ccnc(Cl)c3)n2)CC1.CC(C)N.O=C([O-])[O-].[Ar].[Cs+].[Cs+]>>CC(C)Nc1cc(-c2cc([N+](=O)[O-])cc(N3CCN(C(=O)OC(C)(C)C)CC3)n2)ccn1",
        "output": "70"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc2ncoc2c1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>BrCc1ccc2ncoc2c1",
        "output": "29"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Nc1cc(C)c(C(C)=O)c(Cl)c1.CCO.Cl.[Na+].[OH-]>>CC(=O)c1c(C)cc(N)cc1Cl",
        "output": "66"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Br.C1COCCO1.COc1ccc(CN2CC3(CCCC(COCc4ccccc4)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)cc1.[Na+].[OH-]>>COc1ccc(CN2CC3(CCCC(CO)(Cn4cnc5ccc(C#N)cc54)C3)OC2=O)cc1",
        "output": "178"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCOc1ccc(C2(O)CCN(C(=O)OCc3ccccc3)CC2)cc1.CO>>CCCCCCOc1ccc(C2(O)CCNCC2)cc1",
        "output": "428"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COCC(=O)Cl.COCC(=O)N1CC(C)(C)N(Cc2cc(-c3ccc(O)cc3F)nc3[nH]nc(C)c23)CC1(C)C.Cc1n[nH]c2nc(-c3ccc(O)cc3)cc(CN3CC4(CCCC4)NCC3C)c12>>COCC(=O)N1CC(C)N(Cc2cc(-c3ccc(O)cc3)nc3[nH]nc(C)c23)CC12CCCC2",
        "output": "125"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.COCCl.COc1nc([Si](C)(C)C)cc(I)c1CO.ClCCl>>COCOCc1c(I)cc([Si](C)(C)C)nc1OC",
        "output": "598"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CC1(C)C2CCC1(N)CC2.c1ccncc1>>CC(=O)NC12CCC(CC1)C2(C)C",
        "output": "45"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)O.CC1(C)C=Cc2ccc(F)c(C#N)c2O1.[K+].[OH-]>>CC1(C)C=Cc2ccc(F)c(C(N)=O)c2O1",
        "output": "419"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CNS(=O)(=O)c1cccc(Nc2cc(Nc3ccc(C(=O)NCC(=O)[O-])cc3)ncn2)c1.CO.O.[Li+].[OH-]>>CNS(=O)(=O)c1cccc(Nc2cc(Nc3ccc(C(=O)NCC(=O)O)cc3)ncn2)c1",
        "output": "151"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1C(C(=O)O)CC2CC1C2(C)C.CO.O=S(Cl)Cl>>CC1C(C(=O)Cl)CC2CC1C2(C)C",
        "output": "53"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.O=C(O)CCc1cc(F)cc(F)c1>>OCCCc1cc(F)cc(F)c1",
        "output": "231"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCOC(=O)OCCCC(=O)Cl.CCOC(C)=O.CN(C)C=O.C[C@@H](S[C@H]1CO[C@H](/C=C/C=C/c2ccc(C#N)cc2F)OC1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F.[Cl-].[H-].[NH4+].[Na+]>>C=CCOC(=O)OCCCC(=O)O[C@@](Cn1cncn1)(c1ccc(F)cc1F)[C@@H](C)S[C@H]1CO[C@H](/C=C/C=C/c2ccc(C#N)cc2F)OC1",
        "output": "126"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.Cc1cc(O)ccc1N.O.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>Cc1cc(O)ccc1NS(=O)(=O)c1ccc([N+](=O)[O-])cc1",
        "output": "68"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(Cc2cccc(OCC(F)(F)c3cccc([N+](=O)[O-])c3)c2)OCCO1.CO.[Pd]>>CC1(Cc2cccc(OCC(F)(F)c3cccc(N)c3)c2)OCCO1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.ClCCl.O=[N+]([O-])c1cc(OC[C@H]2CCCN2)cc(C(F)(F)F)c1>>CC(=O)N1CCC[C@@H]1COc1cc([N+](=O)[O-])cc(C(F)(F)F)c1",
        "output": "369"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.COc1ccccc1-c1nn(COCC[Si](C)(C)C)c2ncc(Br)cc12.[Na+]>>COc1ccccc1-c1nn(COCC[Si](C)(C)C)c2ncc(B3OC(C)(C)C(C)(C)O3)cc12",
        "output": "943"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCc1nc2c(N)nc3ccccc3c2n1CCCCN.ClCCl.O=S(=O)(Cl)c1ccccc1.c1ccncc1>>CCCCc1nc2c(N)nc3ccccc3c2n1CCCCNS(=O)(=O)c1ccccc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)(C)OC(=O)N1CC(C#N)CC1c1ncc(-c2ccc(Br)cc2)[nH]1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(C)OC(=O)N1CC(C#N)CC1c1ncc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)[nH]1",
        "output": "942"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)NCCCS(=O)(=O)Cl.CC(C)(CO)CCCNC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.ClCCl>>CC(=O)NCCCS(=O)(=O)OCC(C)(C)CCCNC(=O)OC(C)(C)C",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N1CCNCC1.O=C(O)Cc1cc(Cl)cc2c(-c3ccccc3)onc12>>CC(=O)N1CCN(C(=O)Cc2cc(Cl)cc3c(-c4ccccc4)onc23)CC1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(C)Oc1ccc(-c2cc(C(=O)Nc3ccc(C=O)cc3Cl)no2)cc1Cl.CC(N)CC(=O)O.CO.ClCCl.[BH3-]C#N.[Na+]>>CC(CC(=O)O)NCc1ccc(NC(=O)c2cc(-c3ccc(OC(C)C)c(Cl)c3)on2)c(Cl)c1",
        "output": "468"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cc1ccc(Nc2cc(OCCN3C(=O)c4ccccc4C3=O)nnc2C(N)=O)nc1C.NN>>Cc1ccc(Nc2cc(OCCN)nnc2C(N)=O)nc1C",
        "output": "242"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)C[C@@](C)(c2cc(N)ccc2F)NC(=S)CO1.O=C(O)c1ccc(Cl)cn1>>CC1(C)C[C@@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)NC(=S)CO1",
        "output": "985"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cn1ccc2ncnc(Oc3ccc([N+](=O)[O-])cc3F)c21.[Cl-].[NH4+].[Zn]>>Cn1ccc2ncnc(Oc3ccc(N)cc3F)c21",
        "output": "335"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NCc1cccc(Oc2cc(Cl)ccc2N(Cc2ccc(O)cc2)C(=O)CCC(=O)O)c1.CCN(CC)CC.CCOP(=O)(C#N)OCC.CN(C)C=O.NCc1ccccc1F.O>>CC(C)(C)OC(=O)NCc1cccc(Oc2cc(Cl)ccc2N(Cc2ccc(O)cc2)C(=O)CCC(=O)NCc2ccccc2F)c1",
        "output": "599"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cc(-c2cnc3[nH]cc(-c4c(C)nn(Cc5cc(F)cc(F)c5)c4C)c3c2)cnc1NC(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>COc1cc(-c2cnc3[nH]cc(-c4c(C)nn(Cc5cc(F)cc(F)c5)c4C)c3c2)cnc1N",
        "output": "885"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCOC(=O)CNc1ncnc(Cl)c1[N+](=O)[O-].CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CNc1ncnc(N2CCN(C(=O)OC(C)(C)C)CC2)c1[N+](=O)[O-]",
        "output": "296"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Cl.N#Cc1ccc(-c2ccc(OC(F)(F)F)c(CN[C@H]3CCNC[C@H]3c3ccccc3)c2)c(F)c1.O=C(O)CN1C(=O)CNC1=O>>N#Cc1ccc(-c2ccc(OC(F)(F)F)c(CN[C@H]3CCN(C(=O)CN4C(=O)CNC4=O)C[C@H]3c3ccccc3)c2)c(F)c1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)C1CCN(S(C)(=O)=O)CC1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CS(=O)(=O)N1CCC(CO)CC1",
        "output": "225"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Cc1cc(NCCNC2CCOCC2)n2nc(C)c(-c3c(Cl)cc(O)cc3Cl)c2n1.ClCCl>>Cc1cc(NCCN(C(=O)OC(C)(C)C)C2CCOCC2)n2nc(C)c(-c3c(Cl)cc(O)cc3Cl)c2n1",
        "output": "694"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CON.Cl.O=Cc1ccc2[nH]c3c(c2c1)CC(NC(=O)C1CC1)CC3.[Na+].[OH-]>>CON=Cc1ccc2[nH]c3c(c2c1)CC(NC(=O)C1CC1)CC3",
        "output": "30"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)C(C)OP(=O)(CC(C)=CCc1c(O)c2c(c(C)c1OC)COC2=O)Oc1ccccc1.[Na+].[OH-]>>COc1c(C)c2c(c(O)c1CC=C(C)CP(=O)(Oc1ccccc1)OC(C)C(=O)O)C(=O)OC2",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1c(C)cnc(CO)c1C.ClC(Cl)Cl.O=[Mn]=O>>COc1c(C)cnc(C=O)c1C",
        "output": "263"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Clc1cccc2c(C3CCNCC3)c[nH]c12.O=Cc1cccc2ccccc12>>Clc1cccc2c(C3CCN(Cc4cccc5ccccc45)CC3)c[nH]c12",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrB(Br)Br.COc1ccc(C(=O)c2cccc(F)c2)cc1.ClCCl.O>>O=C(c1ccc(O)cc1)c1cccc(F)c1",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCC(C(=O)OCC)c1ccc([N+](=O)[O-])cc1.[Pd]>>CCCC(C(=O)OCC)c1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC(=O)Cl.Cc1nc2c(N)nc3ccccc3c2n1CCCCN>>CCCC(=O)NCCCCn1c(C)nc2c(N)nc3ccccc3c21",
        "output": "45"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)[Si](OS(=O)(=O)C(F)(F)F)(C(C)C)C(C)C.CC(c1ccccc1)N1C=CC(c2ccc(OCc3ccccc3)cc2)C(O)C1.Cc1cccc(C)n1.ClCCl.O>>CC(c1ccccc1)N1C=CC(c2ccc(OCc3ccccc3)cc2)C(O[Si](C(C)C)(C(C)C)C(C)C)C1",
        "output": "839"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCS(=O)(=O)Nc1ccc(F)c(C(=O)O)c1F.CCN=C=NCCCN(C)C.CCc1cc2cc(N)cnc2[nH]1.CN(C)C=O.On1nnc2ccccc21>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(CC)cc3c2)c1F",
        "output": "759"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C[O-].Cc1cc(Cl)cc(N)n1.Cl.[Na+]>>COc1cc(C)nc(N)c1",
        "output": "651"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCCBr.C1CCOC1.Cl.FC(F)(F)c1c(Cl)cccc1Br.O=C=O.[Mg]>>O=C(O)c1cccc(Cl)c1C(F)(F)F",
        "output": "654"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COc1cc(C(=O)N(CCCc2ccccc2)Cc2nc(C(=O)NS(=O)(=O)N3CCC(O[Si](C)(C)C(C)(C)C)C3)cs2)cc(OC)c1C.[F-]>>COc1cc(C(=O)N(CCCc2ccccc2)Cc2nc(C(=O)NS(=O)(=O)N3CCC(O)C3)cs2)cc(OC)c1C",
        "output": "708"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=Cc1cccc(-c2nc(CCOc3ccc4c(c3)CC[C@H]4CC(=O)OCC)c(C)o2)c1.CCO.O.[Li+].[OH-]>>C=Cc1cccc(-c2nc(CCOc3ccc4c(c3)CC[C@H]4CC(=O)O)c(C)o2)c1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(C)(C)O.CN(CCO)C(=O)C(C)(C)c1ccc(Cl)nc1.COc1cc(Cl)c(OC)c(P(C2CCCCC2)C2CCCCC2)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.COc1ccc(OC)c(P(C2CCCCC2)C2CCCCC2)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.N#C[C@@]1(C2CC2)CCN(c2ccnc(N)c2)C1=O.NCCc1[c-]cccc1.O=C([O-])O.O=C([O-])[O-].[K+].[K+].[Na+].[Pd+2]>>CN(CCO)C(=O)C(C)(C)c1ccc(Nc2cc(N3CC[C@@](C#N)(C4CC4)C3=O)ccn2)nc1",
        "output": "606"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COc1ccc(C=O)cc1OC.Cl.N[C@@H]1C[C@H]1c1ccc(NC(=O)c2cccc(Br)c2)cc1.O.O=C([O-])O.[BH4-].[Na+].[Na+]>>COc1ccc(CN[C@@H]2C[C@H]2c2ccc(NC(=O)c3cccc(Br)c3)cc2)cc1OC",
        "output": "468"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COc1ccc2c(c1)NC(=O)CC2.ClCCl>>O=C1CCc2ccc(O)cc2N1",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN(C)c1nc(N[C@H]2CCNC2)nc2c1sc1ccccc12.Cl.NN1CCCC1.O=C(O)Cc1ccc(OC(F)(F)F)cc1.On1nnc2ccccc21>>CN(C)c1nc(N[C@H]2CCN(C(=O)Cc3ccc(OC(F)(F)F)cc3)C2)nc2c1sc1ccccc12",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(O)c1ccc(-c2cc(C(N)=O)c(Nc3cccc(CO)n3)s2)c(F)c1.CI.CN(C)C=O.[H-].[Na+]>>COCc1cccc(Nc2sc(-c3ccc(C(C)(C)O)cc3F)cc2C(N)=O)n1",
        "output": "140"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.N#CC(Br)c1ccccc1.[N-]=[N+]=NCc1ccc(C(=N)NC(=O)OCc2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N=C(NC(=O)OCc1ccccc1)c1ccc(CN)cc1",
        "output": "562"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCN1.CN(C)C=O.ClCCOc1cccc2c1c1cccc3c1n2C(c1ccccc1)CO3.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>c1ccc(C2COc3cccc4c5c(OCCN6CCOCC6)cccc5n2c34)cc1",
        "output": "138"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.O.O=C1CCC(=O)N1Br.O=C1COc2cccnc2N1>>O=C1COc2cc(Br)cnc2N1",
        "output": "518"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.CNC1CCN(C(=O)OC(C)(C)C)CC1.COC(=O)c1nc(Cl)cc(Cl)c1Cl>>COC(=O)c1nc(Cl)cc(N(C)C2CCN(C(=O)OC(C)(C)C)CC2)c1Cl",
        "output": "398"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCN(C(=O)c2ccccc2)C1.CCOC(C)=O.CI.CN(C)C=O.O.[H-].[Na+]>>CN(C(=O)OC(C)(C)C)[C@H]1CCN(C(=O)c2ccccc2)C1",
        "output": "803"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCc1ccc(Oc2cccc(C#N)c2)cc1.CCO.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CCCc1ccc(Oc2cccc(CN)c2)cc1",
        "output": "175"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CCCN(c3ncc(-n4cnnn4)cn3)C2)CC1.Cl>>c1nc(N2CCCC3(CCNCC3)C2)ncc1-n1cnnn1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)C(F)(F)F.O=C(O)c1nc2c(C(F)(F)F)cc(Br)cn2c1Cl.O=C1OCCN1[C@@H]1CCNC[C@H]1O>>O=C(c1nc2c(C(F)(F)F)cc(Br)cn2c1Cl)N1CC[C@@H](N2CCOC2=O)[C@H](O)C1",
        "output": "729"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1cc2ncnc(Nc3nc4ccc([N+](=O)[O-])cc4s3)c2cc1OC.[H][H].[Pd]>>COc1cc2ncnc(Nc3nc4ccc(N)cc4s3)c2cc1OC",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)n1ccc2c3c(ccc21)NC(C(=O)OCCc1ccc([N+](=O)[O-])cc1)C3.O=C(O)C(F)(F)F>>O=C(OCCc1ccc([N+](=O)[O-])cc1)C1Cc2c(ccc3[nH]ccc23)N1",
        "output": "848"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCOCCOCCOCCOCCO1.C=CCBr.CC#N.CC(C)(C)[O-].O=C(NCCCCc1ccc(O)cc1)OCc1ccccc1.[K+]>>C=CCOc1ccc(CCCCNC(=O)OCc2ccccc2)cc1",
        "output": "77"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccc(Br)cc1.CCOCC.CN(C)C=O.COC(=O)c1cccc(-c2c(C)[nH]c3ccc(OC)cc23)c1.[H-].[Na+]>>COC(=O)c1cccc(-c2c(C)n(Cc3ccc(Br)cc3)c3ccc(OC)cc23)c1",
        "output": "528"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOCC.CN(C)C=O.COc1cc(C2(F)COC2)ccc1Br.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1cc(C2(F)COC2)ccc1B1OC(C)(C)C(C)(C)O1",
        "output": "942"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)c1cccc(Br)c1.Cc1cc(O)ccc1-n1c(C)nc2c(C(F)(F)F)cccc21>>Cc1cc(Oc2cccc(S(C)(=O)=O)c2)ccc1-n1c(C)nc2c(C(F)(F)F)cccc21",
        "output": "238"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(C(=O)O)cc1N.FC(F)(F)c1cc(Cl)nc(-c2cnccn2)n1>>COc1ccc(C(=O)O)cc1Nc1cc(C(F)(F)F)nc(-c2cnccn2)n1",
        "output": "161"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=Cc1ccc(S(=O)(=O)c2ccccc2F)cn1.CC#N.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.CCOC(C)=O.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.Fc1ccccc1I.[Pd+2]>>O=S(=O)(c1ccc(/C=C/c2ccccc2F)nc1)c1ccccc1F",
        "output": "725"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(C)nc(N2CC3CNCC3C2)n1.F[P-](F)(F)(F)(F)F.O=C(O)c1sccc1-n1cccc1>>Cc1cc(C)nc(N2CC3CN(C(=O)c4sccc4-n4cccc4)CC3C2)n1",
        "output": "857"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCc1nc(OC)n(-c2ccc3c(c2)CC(C)(C)O3)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1nc(OC)n(-c2ccc3c(c2)CC(C)(C)O3)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CCCCCC(C)C(C)c1cc(N)c2c(c1)OC(C)(C)c1ccncc1-2.CCOCC.c1ccncc1>>CCCCCC(C)C(C)c1cc(NC(C)=O)c2c(c1)OC(C)(C)c1ccncc1-2",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CI.CN(C)C=O.COc1cc[nH]c(=O)c1.O=C([O-])[O-].[K+].[K+]>>COc1ccn(C)c(=O)c1",
        "output": "191"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.NC1CC1.O=[N+]([O-])c1ccc(Cl)c(S(=O)(=O)Cl)c1Cl>>O=[N+]([O-])c1ccc(Cl)c(S(=O)(=O)NC2CC2)c1Cl",
        "output": "43"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC1(c2c[nH]c3c(N)cccc23)CCc2cc(F)ccc21.O=S(=O)(Cl)c1ccccc1>>CCC1(c2c[nH]c3c(NS(=O)(=O)c4ccccc4)cccc23)CCc2cc(F)ccc21",
        "output": "554"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccnc(OCc2c(-c3ccccc3)noc2C)c1.Cl.O.O.[Li+].[OH-]>>Cc1onc(-c2ccccc2)c1COc1cc(C(=O)O)ccn1",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCCn2c1cc(Cl)nc2=O.NCc1cc(F)cc(F)c1>>CN1CCCn2c1cc(NCc1cc(F)cc(F)c1)nc2=O",
        "output": "165"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.CN(C)C=O.C[C@H](N)c1nc2cccc(Cl)c2c(=O)n1N1CCN(C(=O)OC(C)(C)C)CC1.F[P-](F)(F)(F)(F)F.Nc1nccnc1C(=O)O.O>>C[C@H](NC(=O)c1nccnc1N)c1nc2cccc(Cl)c2c(=O)n1N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "697"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCCCCC#Cc1ccc(C=O)cc1.Nc1ccc(C(F)(F)F)cc1>>CCCCCCCCCCC#Cc1ccc(CNc2ccc(C(F)(F)F)cc2)cc1",
        "output": "359"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Nc1ccc(CCCCOC(C)=O)cc1.CCO.O.O=C([O-])[O-].[K+].[K+]>>CC(=O)Nc1ccc(CCCCO)cc1",
        "output": "225"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COCCCOc1ccc2c(COc3cccc4[nH]c(C(=O)O)cc34)coc2c1.C[C@H]1CN(CCC2(O)CCC(N)CC2)CC[C@@H]1O>>COCCCOc1ccc2c(COc3cccc4[nH]c(C(=O)NC5CCC(O)(CCN6CC[C@H](O)[C@@H](C)C6)CC5)cc34)coc2c1",
        "output": "137"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCCc1ccccc1.O=Cc1ccc2cc[nH]c2c1>>O=Cc1ccc2ccn(CCc3ccccc3)c2c1",
        "output": "470"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.O=C(O)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1>>O=C(c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1)N1CCOCC1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC2=NCCCN2CC1.CC#N.CC1CNCC1CN.CCn1cc(C(=O)O)c(=O)c2cc(F)c(F)c(F)c21>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CC(C)C(CN)C3)c(F)c21",
        "output": "676"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CN(C)C=O.O=C(O)[C@](O)(c1ccccc1)c1cccc(OCCCCC2OCCO2)c1.O=C(c1ncc[nH]1)c1ncc[nH]1.OCC1CCN(Cc2ccccc2)CC1>>O=C(OCC1CCN(Cc2ccccc2)CC1)[C@](O)(c1ccccc1)c1cccc(OCCCCC2OCCO2)c1",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)NCCCS(=O)(=O)Cl.CCN(CC)CC.CN(C)c1ccncc1.COC(=O)/C=C/[C@H](O[Si](C)(C)C(C)(C)C)C(C)(C)CO.ClCCl>>COC(=O)/C=C/[C@H](O[Si](C)(C)C(C)(C)C)C(C)(C)COS(=O)(=O)CCCNC(C)=O",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CNS(=O)(=O)c1cc([N+](=O)[O-])c(OCC(F)(F)F)cc1F.CO.[Pd]>>CNS(=O)(=O)c1cc(N)c(OCC(F)(F)F)cc1F",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCCCC.CN(C)C=O.Cc1ccsc1C1OCCO1.[Cl-].[Li]CCCC.[NH4+]>>Cc1cc(C=O)sc1C1OCCO1",
        "output": "617"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)CC(=O)O.CCN(CC)CC.CN(C)C=O.Cc1ccncc1CNC1CCN(C(C)CCNC(=O)OC(C)(C)C)CC1.ClCCl.O=C(Cl)C(=O)Cl>>Cc1ccncc1CN(C(=O)CC(C)(C)C)C1CCN(C(C)CCNC(=O)OC(C)(C)C)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1c[nH]c2c1CCc1cnccc1-2.[K+].[OH-]>>O=C(O)c1c[nH]c2c1CCc1cnccc1-2",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCNC(=O)C(F)(F)F.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.CN(C)C=O.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.O=C(N(CC1CCCCC1)c1cccc(Br)c1)C(F)(F)F.[Pd+2]>>O=C(NC/C=C/c1cccc(N(CC2CCCCC2)C(=O)C(F)(F)F)c1)C(F)(F)F",
        "output": "539"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cc(B2OC(C)(C)C(C)(C)O2)nn1Cc1c(C)cccc1C.[Na+].[OH-]>>Cc1cccc(C)c1Cn1nc(B2OC(C)(C)C(C)(C)O2)cc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CN1CCC(C2CCNCC2)CC1.CCc1ccc(C[C@@H](NC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc1CC>>CCOC(=O)CN1CCC(C2CCN(C(=O)[C@@H](Cc3ccc(CC)c(CC)c3)NC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C(CC(F)(F)F)CC(F)(F)F.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCC(CC(F)(F)F)CC(F)(F)F",
        "output": "225"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.COC(=O)COc1cccc(Nc2ncnc3oc(-c4ccc(Br)cc4)c(-c4ccc(F)cc4)c23)c1.ClCCl.[Pd]>>COC(=O)COc1cccc(Nc2ncnc3oc(-c4ccccc4)c(-c4ccc(F)cc4)c23)c1",
        "output": "350"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNCCO.COc1ccc(N(C)c2nc(Cl)nc3ccccc23)cc1>>COc1ccc(N(C)c2nc(N(C)CCO)nc3ccccc23)cc1",
        "output": "36"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOCC.Cl.Fc1ccc(-c2ccc(C#CC3CCC4(CC3)OCCO4)cc2)cc1>>O=C1CCC(C#Cc2ccc(-c3ccc(F)cc3)cc2)CC1",
        "output": "251"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCc1cc(-c2nnc(C)o2)c(C)nc1OC.C[Si](C)(C)Cl.[I-].[Na+]>>CCc1cc(-c2nnc(C)o2)c(C)[nH]c1=O",
        "output": "758"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CN1CCCC1=O.Cc1cc(C)c(-c2csc(NC(=O)c3ccnc(Cl)c3)n2)c(C)c1.O>>Cc1cc(C)c(-c2csc(NC(=O)c3ccnc(N4CCCCC4)c3)n2)c(C)c1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1C(=O)OCC.Cl.O>>CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1C(=O)O",
        "output": "5"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)OB(c2ccc(NC(=O)CCC(=O)O)cc2)OC1(C)C.Oc1cccc(-c2ccc3c(Br)c(O)ccc3c2)c1>>O=C(O)CCC(=O)Nc1ccc(-c2c(O)ccc3cc(-c4cccc(O)c4)ccc23)cc1",
        "output": "933"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.ClC(Cl)Cl.Nc1ccccc1CSc1ncc[nH]1.O=C(OO)c1cccc(Cl)c1>>Nc1ccccc1CS(=O)c1ncc[nH]1",
        "output": "595"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.COCCOC.N#Cc1cc(Cl)ncc1Cl.O=C([O-])[O-].OB(O)c1ccccc1.[Na+].[Na+]>>N#Cc1cc(-c2ccccc2)ncc1Cl",
        "output": "865"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.OCC12CC3CC(CC(C3)C1)C2.[H-].[Na+].[O-][n+]1ccc(Cl)cc1>>[O-][n+]1ccc(OCC23CC4CC(CC(C4)C2)C3)cc1",
        "output": "651"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "N.O=C(O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1.O=S(Cl)Cl>>NC(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1",
        "output": "313"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.Cl[Sn]Cl.NC(=O)c1cnn(-c2ccccc2[N+](=O)[O-])c1N.O.O.O=C([O-])O.[Na+]>>NC(=O)c1cnn(-c2ccccc2N)c1N",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(C)=O.ClCCl.NC(=O)c1ncc(-c2ccccc2F)c2c1[nH]c1cc(N)ccc12.O.O=C1CCOCC1.[Na+]>>NC(=O)c1ncc(-c2ccccc2F)c2c1[nH]c1cc(NC3CCOCC3)ccc12",
        "output": "469"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1c(F)cc(Br)cc1F.OB(O)c1ccccc1Cl>>Nc1c(F)cc(-c2ccccc2Cl)cc1F",
        "output": "837"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CC=C(c2ccc(Br)cc2[N+](=O)[O-])CC1.ClCCl.O=C(O)C(F)(F)F>>O=[N+]([O-])c1cc(Br)ccc1C1=CCNCC1",
        "output": "800"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CN(C)Cc1cc2cc([N+](=O)[O-])cnc2[nH]1.CO.O=C([O-])O.[Na+]>>CN(C)Cc1cc2cc(N)cnc2[nH]1",
        "output": "269"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCCCCBr.CN(C)C=O.COC(=O)c1cc[nH]c(=O)c1.O=C([O-])[O-].[Cl-].[Cs+].[Cs+].[Li+]>>COC(=O)c1ccn(CCCCBr)c(=O)c1",
        "output": "470"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)c1ccncc1.Cl.N#Cc1ccc(S(=O)(=O)Cl)cc1.NC(=O)c1cc(-c2ccccc2)cc2c(C3CCNCC3)n[nH]c12>>N#Cc1ccc(S(=O)(=O)N2CCC(c3n[nH]c4c(C(N)=O)cc(-c5ccccc5)cc34)CC2)cc1",
        "output": "99"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCCCBr.CC(=O)Nc1cccc(O)c1.ClCCl.O=C([O-])[O-].[K+].[K+]>>CC(=O)Nc1cccc(OCCCBr)c1",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O.O=C(/C=C/c1ccc([N+](=O)[O-])cc1)c1ccccn1.[Cl-].[Fe].[NH4+]>>Nc1ccc(/C=C/C(=O)c2ccccn2)cc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCN1CCNCC1.Nc1c(F)c(F)c(F)c2c1c(=O)c(C(=O)O)cn2C1CC1>>CCN1CCN(c2c(F)c(N)c3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)CC1",
        "output": "676"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C[C@H](O)C(=O)Nc1cc2c(cc1F)CC(=O)N2.Cc1c(C=O)[nH]c2c1C(=O)N(CCN1CCOCC1)CC2>>Cc1c(C=C2C(=O)Nc3cc(NC(=O)[C@H](C)O)c(F)cc32)[nH]c2c1C(=O)N(CCN1CCOCC1)CC2",
        "output": "440"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(Cl)c1ccccc1I.O=C1C(=O)c2ccccc2C2=C1SCC1(CCNCC1)O2>>O=C1C(=O)c2ccccc2C2=C1SCC1(CCN(C(=O)c3ccccc3I)CC1)O2",
        "output": "201"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.Cc1nc(C2CCN(Cc3ccccc3)C2)ccc1[N+](=O)[O-].O.[Cl-].[Fe].[NH4+]>>Cc1nc(C2CCN(Cc3ccccc3)C2)ccc1N",
        "output": "269"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Nc1ccc2c(c1)CC(C(=O)O)C2.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1ccc2c(c1)nc(C(C)(C)O)n2C1CCNCC1.Cl.O.On1nnc2ccccc21>>Cc1ccc2c(c1)nc(C(C)(C)O)n2C1CCN(C(=O)C2Cc3ccc(NC(=O)OC(C)(C)C)cc3C2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COc1ccc(CCc2nc(C)c(OCc3ccccc3)c(CO)c2CO)cc1.[Pd]>>COc1ccc(CCc2nc(C)c(O)c(CO)c2CO)cc1",
        "output": "264"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCc1cc2c(Oc3ccc(C(=O)N(C)C)cc3)cc(C(=O)O)cc2o1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc(N)nc1.F[P-](F)(F)(F)(F)F.O>>CCc1cc2c(Oc3ccc(C(=O)N(C)C)cc3)cc(C(=O)Nc3ccc(C)cn3)cc2o1",
        "output": "744"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cl.O.O=Cc1cccc(Br)c1.Oc1cccc(Cl)c1.[H-].[Na+].c1ccncc1>>O=Cc1cccc(Oc2cccc(Cl)c2)c1",
        "output": "238"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[O-].C[C@@H]1CNCCN1.Cc1ccccc1.ClCCl.FC(F)(F)c1ccccc1Br.[Na+].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>C[C@@H]1CN(c2ccccc2C(F)(F)F)CCN1",
        "output": "294"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C(O)Cc1cc(O)cc(C(F)(F)F)c1.O=S(=O)(Cc1cccc(F)c1)c1ccc(F)c(Cl)c1>>O=C(O)Cc1cc(Oc2ccc(S(=O)(=O)Cc3cccc(F)c3)cc2Cl)cc(C(F)(F)F)c1",
        "output": "564"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CN(C)CCOc1ccccc1[N+](=O)[O-].[Pd]>>CN(C)CCOc1ccccc1N",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1.Cc1noc(CC2CCC(c3ncc(-c4ccc(N)cc4)s3)CC2)n1.O=C=Nc1ccccc1>>Cc1noc(CC2CCC(c3ncc(-c4ccc(NC(=O)Nc5ccccc5)cc4)s3)CC2)n1",
        "output": "473"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.N.NN.O=[N+]([O-])c1cnc(Cl)c([N+](=O)[O-])c1>>NNc1ncc([N+](=O)[O-])cc1[N+](=O)[O-]",
        "output": "417"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CNC1.CCCO.CCN(C(C)C)C(C)C.Clc1ccc(Cl)nn1>>Clc1ccc(N2CCC2)nn1",
        "output": "406"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COC(=O)c1ccc(C)c(-c2cnc3oc(-c4ccc(F)cc4)c(Br)c3c2)c1.[Na+].[OH-]>>Cc1ccc(C(=O)O)cc1-c1cnc2oc(-c3ccc(F)cc3)c(Br)c2c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O.O=C(O)c1cccc(I)c1.O=S(=O)(O)O>>COC(=O)c1cccc(I)c1",
        "output": "33"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc2c(c(Cl)c1Cl)C(=O)C(c1ccccc1)C2.Cl.Cl.c1ccncc1>>O=C1c2c(cc(O)c(Cl)c2Cl)CC1c1ccccc1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.COCCCN.N#Cc1ccc(OCc2ccccc2)cc1F>>COCCCNc1cc(OCc2ccccc2)ccc1C#N",
        "output": "572"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN1Cc2nc3c(Br)cccc3c(N)c2C1=O.COc1ncccc1B(O)O>>CCN1Cc2nc3c(-c4cccnc4OC)cccc3c(N)c2C1=O",
        "output": "883"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NC(=O)Cc1ccccc1N.O=C(O)c1cccc(Br)c1>>NC(=O)Cc1ccccc1NC(=O)c1cccc(Br)c1",
        "output": "50"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2cccc(N)c2)CC1.CS(=O)(=O)c1ccc(-c2cccn3nc(Cl)nc23)cc1.c1ccc(P(C2CCCCC2)C2CCCCC2)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c1>>CC(C)(C)OC(=O)N1CCC(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1",
        "output": "990"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)O.CCOC(=O)CN1CCNCC1.CN(C)C=O.Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(=O)NCC=O)c[nH]4)c3)cc2)c1.O.[BH3-]C#N.[Na+]>>CCOC(=O)CN1CCN(CCNC(=O)c2c[nH]c(-c3cc(Oc4ccc(NC(=O)Nc5cc(C)ccc5F)cc4)ccn3)c2)CC1",
        "output": "484"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#Cc1ccc2c(c1)C(C)(C)CC(C)(C)O2.CCCCCC.CCN(CC)CC.CCOC(=O)Cc1ccc(I)cc1F.CCOC(C)=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>CCOC(=O)Cc1ccc(C#Cc2ccc3c(c2)C(C)(C)CC(C)(C)O3)cc1F",
        "output": "664"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1sc(Cl)nc1C(C)=O.COC(OC)N(C)C.Cc1ccccc1>>COC(=O)c1sc(Cl)nc1C(=O)/C=C/N(C)C",
        "output": "898"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cc2cc(F)c(C(C)(F)F)nc2nc1C(F)(F)F.O=C(O)c1ccc2cccnc2n1>>CC(F)(F)c1nc2nc(C(F)(F)F)c(C(=O)O)cc2cc1F",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cc1ccc(C=C2C(=O)Nc3ccccc32)c(-c2ccc(C(=O)O)cc2)c1.O=S(=O)(O)O>>COC(=O)c1ccc(-c2cc(C)ccc2C=C2C(=O)Nc3ccccc32)cc1",
        "output": "33"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)NS(=O)(=O)c1ccccc1-c1cccnc1[N+](=O)[O-].CCO.Cl>>CC(C)NS(=O)(=O)c1ccccc1-c1cccnc1N",
        "output": "457"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Oc1c(C)c2c(c([N+](=O)[O-])c1C)OC(C)(C)CC2.CO.O.[Cl-].[Fe].[NH4+]>>CC(=O)Oc1c(C)c(N)c2c(c1C)CCC(C)(C)O2",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(c1ccc(NCC2CCCCC2)c([N+](=O)[O-])c1)S(=O)(=O)c1cccs1.Cl[Sn]Cl.O.O>>CN(c1ccc(NCC2CCCCC2)c(N)c1)S(=O)(=O)c1cccs1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)NCCOc1ccc(C)cc1.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCNCCOc1ccc(C)cc1",
        "output": "112"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrB(Br)Br.COc1cc(C=C(C)c2ccccc2)cc(OC)c1C(C)C>>CC(=Cc1cc(O)c(C(C)C)c(O)c1)c1ccccc1",
        "output": "20"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)c1ccncc1.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(CO)c(OC(C)C)cc12.CS(=O)(=O)Cl.ClCCl.O>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(COS(C)(=O)=O)c(OC(C)C)cc12",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCCCCO.CCCCC[C@@H]1CC[C@@H](c2ccc(-c3ncc(O)cc3F)cc2)CC1>>CCCCCCCCOc1cnc(-c2ccc([C@@H]3CC[C@@H](CCCCC)CC3)cc2)c(F)c1",
        "output": "547"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCCCn1nnc2ccccc21.CC(=O)CC(C)C.O.O=C([O-])[O-].O=c1[nH]c2cc(Cl)ccc2n1C1CCNCC1.[Na+].[Na+]>>O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCn2nnc3ccccc32)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)CCC(=O)NC1(C(=O)NCc2ccc(Oc3ccc(OC)cc3C(F)(F)F)cc2)CC1.Cl.[Na+].[OH-]>>COc1ccc(Oc2ccc(CNC(=O)C3(NC(=O)CCC(=O)O)CC3)cc2)c(C(F)(F)F)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.CCCCC(=O)c1cccc(O)c1.O=C([O-])[O-].OCCOCCCl.[K+].[K+]>>CCCCC(=O)c1cccc(OCCOCCO)c1",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CNS(=O)(=O)Cl.Nc1ccc(-c2ccc3ncc(N4CCOCC4)nc3c2)cc1.c1ccncc1>>CNS(=O)(=O)Nc1ccc(-c2ccc3ncc(N4CCOCC4)nc3c2)cc1",
        "output": "395"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](COC(F)F)C(=O)O.CCN=C=NCCCN(C)C.CCOC(C)=O.CN1CCOCC1.Cl.Cl.ClCCl.N[C@@H](COC(F)F)C(=O)OCc1ccccc1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N[C@@H](COC(F)F)C(=O)N[C@@H](COC(F)F)C(=O)OCc1ccccc1",
        "output": "132"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.COC(=O)CCc1c[nH]c2ccc(F)cc12.Cc1c(Br)cccc1S(=O)(=O)Cl.ClCCl.O=S(=O)([O-])O.[K+].[OH-]>>COC(=O)CCc1cn(S(=O)(=O)c2cccc(Br)c2C)c2ccc(F)cc12",
        "output": "648"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCc1ncc(/C=C/C(Cc2ccccc2)(Cc2ccccc2)C(=O)OCC)n1Cc1ccccc1Cl.CCO.[Na+].[OH-]>>CCCCc1ncc(/C=C/C(Cc2ccccc2)(Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl",
        "output": "281"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CS(=O)(=O)c1ccc(/C(=C\\C2CCCCC2)C(=O)OC)cc1Cl.CCO.[Na+].[OH-]>>C=CS(=O)(=O)c1ccc(/C(=C\\C2CCCCC2)C(=O)O)cc1Cl",
        "output": "58"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1=COCCC1.CC#N.COc1nnc(CO)cc1CO[Si](C)(C)C(C)(C)C.Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1>>COc1nnc(COC2CCCCO2)cc1CO[Si](C)(C)C(C)(C)C",
        "output": "141"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N(C)C.CCOC(C)=O.Cc1cc(O)cc(C)n1.O=C([O-])[O-].O=Cc1ccc(F)cc1.[K+].[K+]>>Cc1cc(Oc2ccc(C=O)cc2)cc(C)n1",
        "output": "564"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CN(CC)C(=O)NCc2ccc(O)cc2)c1.Cl.ClCCl.[Na+].[OH-]>>CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)NCc1ccc(O)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1cc(OCCC(C)(C)O)ccc1Br.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cc(OCCC(C)(C)O)ccc1B1OC(C)(C)C(C)(C)O1",
        "output": "942"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCC.Cl.Cl[Sn]Cl.O.O=[N+]([O-])c1ccc(F)c(Cl)c1F.[Na+].[OH-]>>Nc1ccc(F)c(Cl)c1F",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)OB(c2ccc(-c3cn[nH]c3)cc2)OC1(C)C.CCI.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCn1cc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)cn1",
        "output": "346"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.CN1CCn2c1cc(Cl)nc2=O.OCc1cc(F)c(Oc2ccc(C(F)(F)F)cc2)c(F)c1.[H-].[Na+]>>CN1CCn2c1cc(OCc1cc(F)c(Oc3ccc(C(F)(F)F)cc3)c(F)c1)nc2=O",
        "output": "653"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.Clc1ccccc1/C=C/C1CCNCC1.O.O=C(O)CN1CCOCC1.O=C([O-])[O-].On1nnc2ccccc21.[K+].[K+]>>O=C(CN1CCOCC1)N1CCC(/C=C/c2ccccc2Cl)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(OC)c(COCCOC)c1.[Na+].[OH-]>>COCCOCc1cc(C(=O)O)ccc1OC",
        "output": "386"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCOc1cc(C)cc(C(=O)OC)c1.COC(C)(C)C.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>C=CCOc1cc(C)cc(CO)c1",
        "output": "444"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)c1ccc(N)cc1.N#Cc1ccc(Cl)cc1-c1cc(=O)n(CC(=O)O)c2c1C(=O)CCC2>>CC(C)(C)OC(=O)c1ccc(NC(=O)Cn2c3c(c(-c4cc(Cl)ccc4C#N)cc2=O)C(=O)CCC3)cc1",
        "output": "710"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)C(=O)c1ccc(S(=O)CCOc2ccc3ccccc3c2)cc1.O.[Na+].[OH-]>>O=C(O)C(=O)c1ccc(S(=O)CCOc2ccc3ccccc3c2)cc1",
        "output": "506"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "B#B.C1CCOC1.N#Cc1ccc(N)c([N+](=O)[O-])c1>>NCc1ccc(N)c([N+](=O)[O-])c1",
        "output": "175"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(O)c1ccc(F)cc1.CCN(CC)CC.COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2ncnc(Oc3ccc(NC(=O)OC(C)c4ccc(F)cc4)cc3)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCc1ccc(Oc2ccc(CCC(CO)(CO)NC(C)=O)cc2)cc1.CO.[Na+].[OH-]>>CCCCc1ccc(Oc2ccc(CCC(N)(CO)CO)cc2)cc1",
        "output": "412"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.Clc1nc2nc(-c3ccccc3)cnc2[nH]1.O=C1OC2(CCNCC2)c2ccccc21>>O=C1OC2(CCN(c3nc4nc(-c5ccccc5)cnc4[nH]3)CC2)c2ccccc21",
        "output": "214"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.FC(F)(F)Cc1cc2c(Cl)ncnc2s1.N[C@@H]1CCN(Cc2ccccc2)C[C@H]1O>>O[C@@H]1CN(Cc2ccccc2)CC[C@H]1Nc1ncnc2sc(CC(F)(F)F)cc12",
        "output": "723"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CN(CCCl)Cc1ccccc1.COc1ccc(O)c(C=O)c1.Cc1ccccc1.[H-].[Na+]>>COc1ccc(OCCN(C)Cc2ccccc2)c(C=O)c1",
        "output": "74"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2cc(CO)c(C(F)(F)F)cc2c1=O.CS(=O)(=O)Cl.ClCCl.O>>CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2cc(COS(C)(=O)=O)c(C(F)(F)F)cc2c1=O",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCC(CC(C)C(=O)OCc1ccccc1)C(=O)OCC.CCO.[Pd]>>CCCCC(CC(C)C(=O)O)C(=O)OCC",
        "output": "186"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(O)C1CO1.CCCCCCCCCCCCCCCC(=O)OCC(CSCCC(=O)NCC(=O)NCC(=O)OC(C)(C)C)OC(=O)CCCCCCCCCCCCCCC.O=C(O)C(F)(F)F>>CCCCCCCCCCCCCCCC(=O)OCC(CSCCC(=O)NCC(=O)NCC(=O)O)OC(=O)CCCCCCCCCCCCCCC",
        "output": "278"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.C=Cc1c(N)nc(-c2ccc(N)cc2)nc1C(=O)OC.ClCCl.F[B-](F)(F)F.N#[O+].O.O=S([O-])[O-].[I-].[Na+].[Na+].[Na+]>>C=Cc1c(N)nc(-c2ccc(I)cc2)nc1C(=O)OC",
        "output": "200"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.C[O-].Nc1cc(Cl)cc(NCCO)c1[N+](=O)[O-].[Na+]>>COc1cc(N)c([N+](=O)[O-])c(NCCO)c1",
        "output": "57"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COc1ccc(C(=O)Nc2ccccc2NC(=O)C2CCN(Cc3ccccc3)CC2)cc1.Cl>>COc1ccc(C(=O)Nc2ccccc2NC(=O)C2CCNCC2)cc1",
        "output": "84"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cccc(S(=O)(=O)Cl)c1.Nc1ccc(C(=O)O)c(O)c1>>COc1cccc(S(=O)(=O)Nc2ccc(C(=O)O)c(O)c2)c1",
        "output": "68"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Nn1nc(C(F)(F)F)c2ccccc2c1=O.O=C(Cl)Cc1ccc(Cl)cc1>>O=C(Cc1ccc(Cl)cc1)Nn1nc(C(F)(F)F)c2ccccc2c1=O",
        "output": "450"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.O=[N+]([O-])c1ccc(N2CCN3C[C@H](COc4ccc(F)cc4)CC[C@H]3C2)cc1.[Pd]>>Nc1ccc(N2CCN3C[C@H](COc4ccc(F)cc4)CC[C@H]3C2)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1cc2cc3c(Nc4cc(OC)c(Cl)cc4Cl)c(C#N)cnc3cc2cc1O.Cc1ccc(S(=O)(=O)OCCCCl)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>COc1cc(Nc2c(C#N)cnc3cc4cc(OCCCCl)c(OC)cc4cc23)c(Cl)cc1Cl",
        "output": "438"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc(-c2cccc(N)c2)cc1C.F[P-](F)(F)(F)(F)F.O=C(O)c1cc2cccc(O)c2oc1=O>>COc1ccc(-c2cccc(NC(=O)c3cc4cccc(O)c4oc3=O)c2)cc1C",
        "output": "799"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN1C(=O)C(C)(C)c2cc3nc(-c4n[nH]c5ccc([N+](=O)[O-])cc45)[nH]c3cc21.CO.[Ni]>>CCN1C(=O)C(C)(C)c2cc3nc(-c4n[nH]c5ccc(N)cc45)[nH]c3cc21",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4cncn4CCC)cc2)CCN3CC(C)C)cc1.CSC.ClCCl.O.O=C(OO)c1cccc(Cl)c1>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4cncn4CCC)cc2)CCN3CC(C)C)cc1",
        "output": "500"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COc1ccc(CCN(C)CCOc2ccc([N+](=O)[O-])cc2Cl)cc1OC.O.O=S([O-])S(=O)[O-].[Na+].[Na+]>>COc1ccc(CCN(C)CCOc2ccc(N)cc2Cl)cc1OC",
        "output": "202"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.Nc1cccc(Br)c1.O=[N+]([O-])c1ccc2ncnc(Cl)c2c1>>O=[N+]([O-])c1ccc2ncnc(Nc3cccc(Br)c3)c2c1",
        "output": "352"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.COc1ccc(C(=O)Cl)cc1.ClCCl.NCCCN1CCCCC1>>COc1ccc(C(=O)NCCCN2CCCCC2)cc1",
        "output": "271"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.C[O-].Cc1ccc(Br)c(Cl)[n+]1[O-].[Na+]>>COc1c(Br)ccc(C)[n+]1[O-]",
        "output": "433"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCC(C)(C)CN=C=O.O=C(N1CCOCC1)N1CC(CO)CC(c2ccc(C(F)(F)F)cc2)C1>>COCC(C)(C)CNC(=O)OCC1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)N2CCOCC2)C1",
        "output": "235"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc(C(F)(F)F)ccc1C(=O)c1c(-n2cccc2CO)ccn1S(=O)(=O)c1ccc(C)cc1.CS(C)=O>>COc1cc(C(F)(F)F)ccc1C(=O)c1c(-n2cccc2C=O)ccn1S(=O)(=O)c1ccc(C)cc1",
        "output": "263"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc(-n2nc(C(C)(C)OC)cc2-c2ccc(OCCO[Si](C)(C)C(C)(C)C)cc2)cc1.[F-]>>COc1ccc(-n2nc(C(C)(C)OC)cc2-c2ccc(OCCO)cc2)cc1",
        "output": "708"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cccc(N)c1.ClCCl.O=C(Cl)CCl.[Na+].[OH-]>>Cc1cccc(NC(=O)CCl)c1",
        "output": "9"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC[C@H](C)NC(=O)c1ccc(-c2cc(C(=O)NC3CC3)cc(F)c2C)nc1.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>COC[C@H](C)NC(=O)c1ccc(-c2cc(C(=O)NC3CC3)cc(F)c2C)[n+]([O-])c1",
        "output": "262"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COC(=O)c1cnc(Cl)cc1Nc1cc(C)ccc1C.[Na+].[OH-]>>Cc1ccc(C)c(Nc2cc(Cl)ncc2C(=O)O)c1",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc2c(=O)[nH]c3nccc(Cl)c3c2cc1OC.Nc1ccc(F)cc1>>COc1cc2c(=O)[nH]c3nccc(Nc4ccc(F)cc4)c3c2cc1OC",
        "output": "922"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C)(C)Br.O=C(NCCc1ccc(-c2ccc(O)cc2)cc1)c1ccc(F)cc1>>CCOC(=O)C(C)(C)Oc1ccc(-c2ccc(CCNC(=O)c3ccc(F)cc3)cc2)cc1",
        "output": "305"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1ccc2c(c1)[C@H](NC(=O)c1cccc3ccccc13)CC2.O.O.[Li]O>>O=C(O)c1ccc2c(c1)[C@H](NC(=O)c1cccc3ccccc13)CC2",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.C[C@H](COC1CCCCO1)n1cc(C(=O)c2cncc(N)c2)c2cncnc21.O=C(O)Cc1cccc(C(F)(F)F)c1>>C[C@H](COC1CCCCO1)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)c2cncnc21",
        "output": "724"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CC(C)(C)C1)C2c1ccc(Sc2nc3ccccc3[nH]2)o1.O.[Na+].[OH-]>>CC1(C)CC(=O)C2=C(C1)Nc1c(c[nH]c1C(=O)O)C2c1ccc(Sc2nc3ccccc3[nH]2)o1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "NCC(CC1CC1)c1ccc(C(F)(F)F)nc1.O=C(O)c1cccc(F)c1Cl>>O=C(NCC(CC1CC1)c1ccc(C(F)(F)F)nc1)c1cccc(F)c1Cl",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNC(=O)c1c(-c2ccc(F)cc2)oc2nc(Cl)c(-c3cccc(C(=O)O)c3)cc12.Cl.F[P-](F)(F)(F)(F)F.NC12CC(C1)C2.[Cl-].[NH4+]>>CNC(=O)c1c(-c2ccc(F)cc2)oc2nc(Cl)c(-c3cccc(C(=O)NC45CC(C4)C5)c3)cc12",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CC[C@H](O)[C@H]1C(=O)O.C[Si](C)(C)Cl.[BH4-].[Li+]>>CC(C)(C)OC(=O)N1CC[C@H](O)[C@H]1CO",
        "output": "218"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "B.C1CCOC1.C1CCOC1.CO.N#Cc1ccc(CSC2CCCC2)cc1>>NCc1ccc(CSC2CCCC2)cc1",
        "output": "175"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.CCN(CC)c1ccc(C=O)c(O)c1.CN(N)c1ccccc1>>CCN(CC)c1ccc(C=NN(C)c2ccccc2)c(O)c1",
        "output": "167"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCCO[C@H](C)C(=O)Cl.Cl.ClCCl.O=C(O)c1ccc(O)cc1.c1ccncc1>>CCCCCCO[C@H](C)C(=O)Oc1ccc(C(=O)O)cc1",
        "output": "111"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(B(O)O)cn1.Cc1cc(Br)cc(C)c1Cl>>COc1ccc(-c2cc(C)c(Cl)c(C)c2)cn1",
        "output": "899"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.Cl.ClCCl.NC1CCCc2ccccc21.O=C(O)CN1CCC(c2ccccc2)(c2ccccc2)C1=O>>O=C(CN1CCC(c2ccccc2)(c2ccccc2)C1=O)NC1CCCc2ccccc21",
        "output": "599"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)Nc1cccc(-c2nc(C)c(CO)[nH]2)c1.O=[Mn]=O>>CC(=O)Nc1cccc(-c2nc(C)c(C=O)[nH]2)c1",
        "output": "287"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)O.Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCCCCCC(=O)O)c2cc1C.O=C([O-])O.O=S(=O)(O)O.[Na+]>>Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCCCCCC(=O)OC(C)C)c2cc1C",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CN(C(=O)OC(C)(C)C)C1CN(c2nc3ncc(Br)cc3nc2Cl)C1.C[C@@H](N)CO>>C[C@H](CO)Nc1nc2cc(Br)cnc2nc1N1CC(N(C)C(=O)OC(C)(C)C)C1",
        "output": "148"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1ccc2nc(-c3cc4ccc(Cl)cc4o3)c(N(C)C(C)C)nc2c1.Cl.O.[Na+].[OH-]>>CC(C)N(C)c1nc2cc(C(=O)O)ccc2nc1-c1cc2ccc(Cl)cc2o1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.CC(C)=O.O=C([O-])[O-].O=Cc1ccc(O)cc1.[K+].[K+]>>O=Cc1ccc(OCc2ccccc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](CC(=O)O)C1.CCN=C=NCCCN(C)C.CCO.CCOCC.CN(C)c1ccncc1.Cl>>CCOC(=O)C[C@H]1CCN(C(=O)OC(C)(C)C)C1",
        "output": "47"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(C)=O.NNc1cc(N2CCC(c3ccccc3F)CC2)ncn1.O.O=C(Cl)CC(F)(F)F.O=C([O-])O.[Na+]>>O=C(CC(F)(F)F)NNc1cc(N2CCC(c3ccccc3F)CC2)ncn1",
        "output": "450"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CN(C)C=O.Cn1c(S)nc2ccccc2c1=O.O.O=C(c1ccc(CBr)cc1)c1ccc(Cl)cc1Cl.[Na+].[OH-]>>Cn1c(SCc2ccc(C(=O)c3ccc(Cl)cc3Cl)cc2)nc2ccccc2c1=O",
        "output": "699"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(Cl)OC(=O)Cl.ClCCCl.Clc1c2c(nc3ccc(Br)cc13)CCN(Cc1ccccc1)C2>>Clc1c2c(nc3ccc(Br)cc13)CCNC2",
        "output": "84"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.CN1CCCC1=O.Fc1cc(F)c(F)nc1F.O>>CC(C)(C)OC(=O)N1CCN(c2nc(F)c(F)cc2F)CC1",
        "output": "756"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1=CCC=CC1.Cc1nc(-c2ccc(OCCNC(=O)OCc3ccccc3)cc2)co1>>Cc1nc(-c2ccc(OCCN)cc2)co1",
        "output": "574"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.COC(=O)COc1ccc(O)cc1C.ClCC=C(c1ccc(Br)cc1)c1ccc(Br)cc1.O.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)COc1ccc(OCC=C(c2ccc(Br)cc2)c2ccc(Br)cc2)cc1C",
        "output": "119"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(=O)Cl.Cc1[nH]c2c(-c3cc(C(F)(F)F)ccc3OCC3CC3)ncnc2c1C(=O)N[C@@H]1CC[C@@H](N)CC1.Cl>>CCC(=O)N[C@@H]1CC[C@@H](NC(=O)c2c(C)[nH]c3c(-c4cc(C(F)(F)F)ccc4OCC4CC4)ncnc23)CC1",
        "output": "45"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CN(c1ccc2c(c1)nc(C(C)(C)C)n2CC1CCCCC1)S(=O)(=O)c1ccc([N+](=O)[O-])cc1.[Pd]>>CN(c1ccc2c(c1)nc(C(C)(C)C)n2CC1CCCCC1)S(=O)(=O)c1ccc(N)cc1",
        "output": "401"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN(c1ccccc1)c1nc(N)nc(-c2noc(-c3ccc(C(=O)O)s3)n2)n1.Cl.On1nnc2cccnc21>>CN(c1ccccc1)c1nc(N)nc(-c2noc(-c3ccc(C(=O)N4CCOCC4)s3)n2)n1",
        "output": "857"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)CCCCCCCCCCCCc1ccc(C(=O)OC(C)(C)C)s1.O.O=S(=O)([O-])O.[Na+].[Na+].[OH-]>>CC(C)(C)OC(=O)c1ccc(CCCCCCCCCCCCC(=O)O)s1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.O=C(O)CC1(CO)CC1.O=C([O-])O.O=S(=O)(O)O.[Na+]>>CCOC(=O)CC1(CO)CC1",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)C(N)C1CCC(NC(=O)OC(C)(C)C)CC1.F[P-](F)(F)(F)(F)F.Nc1cc2ccccc2cc1C(=O)O.O=C([O-])O.[Na+]>>COC(=O)C(NC(=O)c1cc2ccccc2cc1N)C1CCC(NC(=O)OC(C)(C)C)CC1",
        "output": "652"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1.CC(C)=O.O.OCCNCCO>>CC(=O)Nc1ccc(S(=O)(=O)N(CCO)CCO)cc1",
        "output": "99"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.ClCCl.O.O=C(CCc1ccc(O)cc1)OCc1ccccc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1ccc(CCC(=O)OCc2ccccc2)cc1",
        "output": "746"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(-c4cnn(CCCO)c4C)nc3C(=O)NC)n2)c(OC)c1)OCC.CCOP(=O)(O)Cc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(-c4cnn(CCCO)c4)cc3C(=O)N(CC)CC)n2)c(OC)c1>>CCOP(=O)(O)Cc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(-c4cnn(CCCO)c4C)nc3C(=O)NC)n2)c(OC)c1",
        "output": "618"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)c1cnc(SC)nc1NC(C)C.[Na+].[OH-]>>CSc1ncc(C(=O)O)c(NC(C)C)n1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(CCCn2ccnc2)ccc1O.ClCc1coc(-c2cccs2)n1>>COc1cc(CCCn2ccnc2)ccc1OCc1coc(-c2cccs2)n1",
        "output": "760"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCCC(CCC=C)OCCCCCCCCCCOc1ccc(C(=O)OC)cc1.CO.Cl.O.[K+].[OH-]>>C=CCCC(CCC=C)OCCCCCCCCCCOc1ccc(C(=O)O)cc1",
        "output": "222"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)c1ccncc1.COc1ccc(CO[C@H]2[C@@H](O)[C@@H](CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)O[C@@H](SC)[C@@H]2N=[N+]=[N-])cc1.ClCCCl.O=C(Cl)c1ccccc1-c1ccccc1>>COc1ccc(CO[C@@H]2[C@@H](N=[N+]=[N-])[C@H](SC)O[C@H](CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)[C@@H]2OC(=O)c2ccccc2-c2ccccc2)cc1",
        "output": "51"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.CCOCC.C[C@]12CC[C@@H]3[C@H]4CCC(=O)C=C4C[C@@H](CCCCCO)[C@H]3[C@@H]1CCC2=O.O.c1ccncc1>>CC(=O)OCCCCC[C@@H]1CC2=CC(=O)CC[C@@H]2[C@H]2CC[C@]3(C)C(=O)CC[C@H]3[C@H]12",
        "output": "254"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(C3CCN(CC(=O)O)CC3)CC2)cc(C)c1O.ClCCl.O=C([O-])O.OCCN1CCOCC1.[Na+]>>Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(C3CCN(CC(=O)OCCN4CCOCC4)CC3)CC2)cc(C)c1O",
        "output": "47"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.CCOP(=O)(NC1CNCCC1C)OCC.O=[N+]([O-])c1cnccc1Cl>>CCOP(=O)(NC1CN(c2ccncc2[N+](=O)[O-])CCC1C)OCC",
        "output": "398"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)c1ccncc1.COc1ccc(-c2cnc(N)c(Cc3ccccc3)n2)cc1.COc1ccc(C(C)C(=O)Cl)cc1.O.c1ccncc1>>COc1ccc(-c2cnc(NC(=O)C(C)c3ccc(OC)cc3)c(Cc3ccccc3)n2)cc1",
        "output": "399"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.Nc1cnccc1OCc1ccccc1>>CS(=O)(=O)Nc1cnccc1OCc1ccccc1",
        "output": "812"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.OCC1Cc2ccc(Cl)c(-c3ccccc3Cl)c2O1>>Cc1ccc(S(=O)(=O)OCC2Cc3ccc(Cl)c(-c4ccccc4Cl)c3O2)cc1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COC(=O)CC(NC(=O)[C@@H]1CCCN(C(=O)CCC2CCN(C(=O)OC(C)(C)C)CC2)C1)c1cc(F)cc(-c2ccc(O)cc2)c1.Cc1ccc(S(=O)(=O)OCCOS(=O)(=O)c2ccc(C)cc2)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)CC(NC(=O)[C@@H]1CCCN(C(=O)CCC2CCN(C(=O)OC(C)(C)C)CC2)C1)c1cc(F)cc(-c2ccc(OCCOS(=O)(=O)c3ccc(C)cc3)cc2)c1",
        "output": "438"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.Cc1ccc2c(-c3cnc4[nH]cc(C(=O)O)c4n3)nn(C)c2c1.Cl.N#CC1(N)CC1.O>>Cc1ccc2c(-c3cnc4[nH]cc(C(=O)NC5(C#N)CC5)c4n3)nn(C)c2c1",
        "output": "737"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1cc(Br)ccc1C.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)c1cc(Br)ccc1CBr",
        "output": "545"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)c1csc(CCc2ccn3c(=O)c(/C=C/C(=O)OC(C)(C)C)c(O)nc3c2)n1.Cc1ccccc1.O=CO>>CC(C)c1csc(CCc2ccn3c(=O)c(/C=C/C(=O)O)c(O)nc3c2)n1",
        "output": "158"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNCCN1.CN(C)C=O.COc1ccc(-c2nc(Cl)sc2Cc2ccccc2)cc1.O.O.[Li]O>>COc1ccc(-c2nc(N3CCNCC3)sc2Cc2ccccc2)cc1",
        "output": "558"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#CCN1CCCc2ccc(O)cc21.C1CCOC1.CC(C)N(C(=O)Cl)C(C)C.CCOC(C)=O.[H-].[Na+]>>C#CCN1CCCc2ccc(OC(=O)N(C(C)C)C(C)C)cc21",
        "output": "425"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN1CCNCC1.COc1nc(Cl)c(F)c(NNC(=O)[C@H](CC2CCCC2)CN(C=O)OCc2ccccc2)n1.CS(C)=O>>CCN1CCN(c2nc(OC)nc(NNC(=O)[C@H](CC3CCCC3)CN(C=O)OCc3ccccc3)c2F)CC1",
        "output": "296"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=C(C)C(=O)Cl.CC(C)c1cccc(C(C)C)c1N1C(=O)c2ccc3c4cccc5c(CCCCCCO)ccc(c6ccc(c2c36)C1=O)c54>>C=C(C)C(=O)OCCCCCCc1ccc2c3ccc4c5c(ccc(c6cccc1c62)c53)C(=O)N(c1c(C(C)C)cccc1C(C)C)C4=O",
        "output": "320"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.O.O=S(=O)(Cl)c1ccccc1.O=[N+]([O-])c1cccc2[nH]ccc12>>O=[N+]([O-])c1cccc2c1ccn2S(=O)(=O)c1ccccc1",
        "output": "648"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.Cc1cc(C(=O)c2ccccc2)ccc1O.Cc1cccc(-n2nnn(C)c2=O)c1CBr.O.O=C([O-])[O-].[K+].[K+]>>Cc1cc(C(=O)c2ccccc2)ccc1OCc1c(C)cccc1-n1nnn(C)c1=O",
        "output": "127"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC(NC(=O)Cn1ncc(N[C@@H]2C[C@@H]3C[C@H]([C@H]2C)C3(C)C)c(Cl)c1=O)C(=O)O.CN(C)C=O.N.O.O=C(n1ccnc1)n1ccnc1>>CCC(NC(=O)Cn1ncc(N[C@@H]2C[C@@H]3C[C@H]([C@H]2C)C3(C)C)c(Cl)c1=O)C(N)=O",
        "output": "313"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(C)=O.Cc1cc(CO)ccc1Br.ClCCl.O=C(Cl)C(=O)Cl>>Cc1cc(C=O)ccc1Br",
        "output": "179"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=[N+]([O-])c1cc2cn[nH]c2cc1O.OCCCCCl>>O=[N+]([O-])c1cc2cn[nH]c2cc1OCCCCCl",
        "output": "478"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1c(C(C)C)cc(C=O)cc1C(C)C.COc1cccc(-c2ccc3c(c2)NC(=O)C3)c1>>COc1cccc(-c2ccc3c(c2)NC(=O)C3=Cc2cc(C(C)C)c(OC)c(C(C)C)c2)c1",
        "output": "439"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrP(Br)Br.CCOCC.CS(=O)(=O)c1ccc(Oc2cc(Cl)ccc2CO)c(Cl)c1>>CS(=O)(=O)c1ccc(Oc2cc(Cl)ccc2CBr)c(Cl)c1",
        "output": "300"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)C=O.COC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OCc1ccc(OC)cc1.O>>COC(=O)[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)OCc1ccc(OC)cc1",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(Br)c(C(F)F)cc1F.[BH4-].[Na+]>>OCc1cc(Br)c(C(F)F)cc1F",
        "output": "444"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)[C@@H]1CCN1C(=O)NC(C)(C)C.Cl.O.[Li+].[OH-]>>CC(C)(C)NC(=O)N1CC[C@H]1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccccc1.Nc1c(O)cccc1C(=O)O.O=C(Cl)c1cccc([N+](=O)[O-])c1.c1ccncc1>>O=C(Nc1c(O)cccc1C(=O)O)c1cccc([N+](=O)[O-])c1",
        "output": "11"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCC.CO.COc1ccc(-c2cc(C(=O)O)n(C)n2)cc1.C[Si](C)(C)C=[N+]=[N-].ClCCl>>COC(=O)c1cc(-c2ccc(OC)cc2)nn1C",
        "output": "195"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccccc1.C=CCc1cccc(C(C)(C)C)c1O.CCCC[N+](CCCC)(CCCC)CCCC.O=C([O-])[O-].[I-].[K+].[K+]>>C=CCc1cccc(C(C)(C)C)c1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CNC1CCN(Cc2ccccc2)CC1.Cc1cc(NC(=O)OC(C)(C)C)cnc1OCC(=O)O>>Cc1cc(NC(=O)OC(C)(C)C)cnc1OCC(=O)N(C)C1CCN(Cc2ccccc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOCC.CN1CCCC1=O.N#C[Cu].Oc1ccc(Br)cc1F>>N#Cc1ccc(O)c(F)c1",
        "output": "531"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.COc1cc2ncnc(N3CCC(n4c(=O)[nH]c5ccc([N+](=O)[O-])cc5c4=O)CC3)c2cc1OC>>COc1cc2ncnc(N3CCC(n4c(=O)c5cc([N+](=O)[O-])ccc5n(Cc5ccccc5)c4=O)CC3)c2cc1OC",
        "output": "389"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC[N+](CC)(CC)Cc1ccccc1.COCCOC.O.O=P(Cl)(Cl)Cl.Oc1cc(OC(F)F)nc(SCc2cccc(F)c2F)n1.[Cl-]>>Fc1cccc(CSc2nc(Cl)cc(OC(F)F)n2)c1F",
        "output": "168"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=C1Cc2cc(C(=O)O)ccc2N1.O=Cc1cc2cc(OCCN3CCCC3)ccc2[nH]1>>O=C1Nc2ccc(C(=O)O)cc2C1=Cc1cc2cc(OCCN3CCCC3)ccc2[nH]1",
        "output": "440"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.Clc1cc(I)cc(Cl)n1.NCC1CCCN(C(=O)OCc2ccccc2)C1>>O=C(OCc1ccccc1)N1CCCC(CNc2cc(I)cc(Cl)n2)C1",
        "output": "70"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.C[C@@H]1O[C@H](OCCCCCCCCCCO)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@@H]1OCc1ccccc1.ClCCl.O=S(=O)(O)O.O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1>>C[C@@H]1O[C@H](OCCCCCCCCCC=O)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@@H]1OCc1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.Clc1cn2nc(Cl)ccc2n1.O>>Clc1cn2nc(N3CCOCC3)ccc2n1",
        "output": "406"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)N.CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(SCc3ccc(C(=O)O)c(F)c3)c2CC1.CCOC(C)=O.CN(C)C=O.ClCCCl.On1nnc2ccccc21>>CC(C)(C)NC(=O)c1ccc(CSc2c(Cl)ccc3c2CCN(C(=O)OC(C)(C)C)CC3)cc1F",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCc1nc2c(C)cc(C(=O)NCc3ccc(Oc4ccc([N+](=O)[O-])c(N(C)C(=O)OC(C)(C)C)c4)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1.CO.[Pd]>>CCCc1nc2c(C)cc(C(=O)NCc3ccc(Oc4ccc(N)c(N(C)C(=O)OC(C)(C)C)c4)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1",
        "output": "335"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(=O)CC1CCc2c1[nH]c1ccc(-c3noc(-c4cc(OC(F)(F)F)cc(-c5cccnc5)c4)n3)cc21.O.[Na+].[OH-]>>O=C(O)CC1CCc2c1[nH]c1ccc(-c3noc(-c4cc(OC(F)(F)F)cc(-c5cccnc5)c4)n3)cc21",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C(O)=[N+](C)C.CN(C)C=O.CN1CCOCC1.Cl.F[P-](F)(F)(F)(F)F.O.O=C(O)c1cc(-c2ccccc2)c(=O)n2c1-c1cc(Cl)ccc1CC2.O=C([O-])O.O[C@H]1CCNC1.[Na+]>>O=C(c1cc(-c2ccccc2)c(=O)n2c1-c1cc(Cl)ccc1CC2)N1CC[C@H](O)C1",
        "output": "256"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cnn(C)c1Br.O.O.[Li+].[OH-]>>Cn1ncc(C(=O)O)c1Br",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)COc2cccc(O)c21.CN(C)C=O.Cc1cc(-n2c(C)n[nH]c2=O)cnc1F>>Cc1cc(-n2c(C)n[nH]c2=O)cnc1Oc1cccc2c1C(C)(C)CO2",
        "output": "727"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(C)=O.NS(=O)(=O)c1cnc(Cl)c(Br)c1.O=C([O-])[O-].Oc1ccc(F)cc1F.[Cs+].[Cs+]>>NS(=O)(=O)c1cnc(Oc2ccc(F)cc2F)c(Br)c1",
        "output": "516"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCCCC.CCOC(=O)CCc1cc(Cl)ccc1OCCc1ccccc1.CCOC(C)=O.N.[Al+3].[H-].[H-].[H-].[H-].[H][H].[Li+]>>OCCCc1cc(Cl)ccc1OCCc1ccccc1",
        "output": "225"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN1CCN(CC(=O)N(C)c2ccc([N+](=O)[O-])cc2)CC1.CO.[Pd]>>CN1CCN(CC(=O)N(C)c2ccc(N)cc2)CC1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.C[O-].O.O=[N+]([O-])c1cc2c(Nc3ccc(OCc4ccccn4)c(Cl)c3)ncnc2cc1F.[Na+]>>COc1cc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1[N+](=O)[O-]",
        "output": "636"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1cc2ccc(O)cc2cn1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COC(=O)c1cc2ccc(OS(=O)(=O)C(F)(F)F)cc2cn1",
        "output": "731"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Cc1cc(=O)c(OCc2ccccc2)c(C(=O)O)o1.NC1CCCCC1.O=C(n1ccnc1)n1ccnc1>>Cc1cc(=O)c(OCc2ccccc2)c(C(=O)NC2CCCCC2)o1",
        "output": "714"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)c1ccc(-c2c3ccccc3c(Br)c3ccccc23)cc1.CC(C)OB(OC(C)C)OC(C)C.CCCCCC.Cl>>CC(C)(C)c1ccc(-c2c3ccccc3c(B(O)O)c3ccccc23)cc1",
        "output": "832"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrP(Br)Br.ClC(Cl)Cl.ClCCl.O.OCc1cc(Cl)cc(Br)c1>>Clc1cc(Br)cc(CBr)c1",
        "output": "300"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)CSc1cnc(N)s1.CCOC(=O)CSc1cnc(NC(=O)N(CC2CCCC2)c2ccc(F)c(OC)c2)s1.COc1cc(NCC2CCCC2)ccc1F.CS(=O)(=O)c1ccc(N(CC2CCCC2)C(=O)Nc2nc(CC(=O)O)cs2)cc1>>COc1cc(N(CC2CCCC2)C(=O)Nc2ncc(SCC(=O)O)s2)ccc1F",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1cc(-c2cccc(C=O)c2)c(OCOC)c(-c2cccc(C=O)c2)c1.CO.Cl.O.[K+].[OH-]>>COCOc1c(-c2cccc(C=O)c2)cc(C(=O)O)cc1-c1cccc(C=O)c1",
        "output": "386"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccccc1.OCC(O)CCl.OCc1ccc2ccc3cccc4ccc1c2c34.[Cs+].[F-]>>OCC(O)COCc1ccc2ccc3cccc4ccc1c2c34",
        "output": "308"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCOC(C)=O.ClCCl.OC1CCN(c2nccnc2OC2CN(c3ccc4ccccc4n3)C2)CC1>>O=C1CCN(c2nccnc2OC2CN(c3ccc4ccccc4n3)C2)CC1",
        "output": "87"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc2c(Cl)nc(Nc3cc[nH]n3)cc2c1.OB(O)c1ccc(C(F)(F)F)cc1>>COc1ccc2c(-c3ccc(C(F)(F)F)cc3)nc(Nc3cc[nH]n3)cc2c1",
        "output": "865"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)CN1C(=O)CCC(C)(C)c2ccc(N)cc21.COc1cc(N2CCOCC2)ccc1Nc1nc(Cl)ncc1Cl>>COc1cc(N2CCOCC2)ccc1Nc1nc(Nc2ccc3c(c2)N(CC(C)C)C(=O)CCC3(C)C)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cc(Cl)c(C)[nH]1.CO.[Li+].[OH-]>>Cc1[nH]c(C(=O)O)cc1Cl",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCC.CCOC(=O)Cl.CCOC(C)=O.CN(C)c1ccncc1.ClCCl.O=C1c2ccccc2C(=O)c2cc(CO)ccc21>>CCOC(=O)OCc1ccc2c(c1)C(=O)c1ccccc1C2=O",
        "output": "144"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)Cn1c(=O)n(C)c(=O)c2c(-c3cccc(C(=O)O)c3)n(Cc3cccc4ccccc34)nc21.N.O>>CC(C)Cn1c(=O)n(C)c(=O)c2c(-c3cccc(C(N)=O)c3)n(Cc3cccc4ccccc34)nc21",
        "output": "358"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(O)c1ccn2c(-c3ccc(F)c(Cl)c3)cnc2c1F.OB(O)c1ccc(F)c(Cl)c1>>CC(C)(O)c1ccn2c(-c3ccc(F)c(-c4ccc(F)c(Cl)c4)c3)cnc2c1F",
        "output": "892"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCOC(=O)CCc1cc(O)ccc1OC.CCOC(C)=O.COc1ccc(F)c(-c2ccc(CCl)nc2CC(C)(C)C)c1.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)CCc1cc(OCc2ccc(-c3cc(OC)ccc3F)c(CC(C)(C)C)n2)ccc1OC",
        "output": "616"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCNCC1.CS(=O)(=O)c1nccc(Oc2ccc(NC(=O)c3cc(F)cc(N4CCOCC4)c3)c3ccccc23)n1>>O=C(Nc1ccc(Oc2ccnc(N3CCCCC3)n2)c2ccccc12)c1cc(F)cc(N2CCOCC2)c1",
        "output": "679"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cnc(N2CCNCC2)c(Cl)c1.Cc1ccc(N=C=O)cc1>>CCOC(=O)c1cnc(N2CCN(C(=O)Nc3ccc(C)cc3)CC2)c(Cl)c1",
        "output": "323"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C[N+](C)(C)Cc1ccccc1.Cl.ClCc1ccccc1Cl.[Na+].[OH-].[OH-].c1cc2c(s1)CCNC2.c1ccccc1>>Clc1ccccc1CN1CCc2sccc2C1",
        "output": "156"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "B.C1CCOC1.CO.O=C(O)c1ccc(CBr)cc1Br>>OCc1ccc(CBr)cc1Br",
        "output": "72"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NC1CCCCC1.O.O=C(O)CCC(=O)c1ccc(-c2ccc(Cl)cc2)cc1>>O=C(O)CCC(O)c1ccc(-c2ccc(Cl)cc2)cc1",
        "output": "24"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)C(=O)c1c[nH]c2ncc(Br)nc12.CCOC(C)=O.OCCc1cccc(B(O)O)c1>>CC(C)(C)C(=O)c1c[nH]c2ncc(-c3cccc(CCO)c3)nc12",
        "output": "876"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)[C@H](Cc1ccc(N2CC(=O)N(CC[Si](C)(C)C)S2(=O)=O)c(OCc2ccccc2)c1)NS(=O)(=O)c1ccccc1.ClCCl.O=C(O)C(F)(F)F>>C[Si](C)(C)CCN1C(=O)CN(c2ccc(C[C@H](NS(=O)(=O)c3ccccc3)C(=O)O)cc2OCc2ccccc2)S1(=O)=O",
        "output": "278"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)C1.CC(C)(C)OC(=O)N1CCCC(N)C1.CC(C)Nc1nc2ccccn2c(=O)c1-c1ccc(Cl)cc1.CCCCc1nc2ccccn2c(=O)c1-c1ccc(Cl)cc1>>CC(C)Nc1nc2ccccn2c(=O)c1-c1ccc(NC2CCN(C(=O)OC(C)(C)C)C2)cc1",
        "output": "304"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.CCN(CC)CC.COc1ccc(Br)c2c1CN(C(=O)OC(C)(C)C)[C@@H]([C@@H](O)[C@@H](N)Cc1cc(F)cc(F)c1)C2>>COc1ccc(Br)c2c1CN(C(=O)OC(C)(C)C)[C@@H]([C@@H](O)[C@H](Cc1cc(F)cc(F)c1)NC(C)=O)C2",
        "output": "339"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)CCN.CS(=O)(=O)c1ccc(Cl)c([N+](=O)[O-])c1.CS(C)=O>>CN(C)CCNc1ccc(S(C)(=O)=O)cc1[N+](=O)[O-]",
        "output": "304"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCC1(c2ccc(Br)cc2)CCCC1>>CS(=O)(=O)OCC1(c2ccc(Br)cc2)CCCC1",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCCBr.COc1c(OC(F)F)ccc(-c2cccc3c2CCC3=O)c1O.O=C([O-])[O-].[K+].[K+]>>CCCOc1c(-c2cccc3c2CCC3=O)ccc(OC(F)F)c1OC",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(CO)cc1.FC(F)(F)c1csc(-c2nc(Cl)cc(Cl)n2)n1.O=C([O-])O.[H-].[Na+].[Na+]>>COc1ccc(COc2cc(Cl)nc(-c3nc(C(F)(F)F)cs3)n2)cc1",
        "output": "653"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.COc1cccc2c1NC(=O)CC2.[H-].[H][H].[Na+]>>COc1cccc2c1N(C)C(=O)CC2",
        "output": "237"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCS(=O)(=O)Cl.Cc1nc(N2C[C@@H]3C[C@H]2CN3)n2nc(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)c2n1.Cl.ClCCl>>CCS(=O)(=O)N1C[C@@H]2C[C@H]1CN2c1nc(C)nc2c(-c3ccc(Cl)cc3)c(-c3ccccc3Cl)nn12",
        "output": "584"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)N.Cc1ccc2c(OCCN3CCC(Cc4cccc(C(=O)O)c4)CC3)cccc2n1>>Cc1ccc2c(OCCN3CCC(Cc4cccc(C(=O)NC(C)C)c4)CC3)cccc2n1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "NC1CC1.O=[N+]([O-])c1ccc(CBr)c(Cl)c1>>O=[N+]([O-])c1ccc(CNC2CC2)c(Cl)c1",
        "output": "446"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1cc(-c2cccnc2)[nH]n1.CO.Cl.O.O.[Li]O>>O=C(O)c1cc(-c2cccnc2)[nH]n1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)[C@@H](Cc1cc(C)c2[nH]ncc2c1)NC(=O)N1CCC(c2cc3ccccc3[nH]c2=O)CC1.O.[Li+].[OH-]>>Cc1cc(C[C@@H](NC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)O)cc2cn[nH]c12",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1ccc2[nH]ncc2c1.O=C=NCc1ccc(C(F)(F)F)cc1>>O=C(NCc1ccc(C(F)(F)F)cc1)Nc1ccc2[nH]ncc2c1",
        "output": "888"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)cnnc2cc1O.ClCCCN1CCCCC1.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)cnnc2cc1OCCCN1CCCCC1",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1ccc(-c2ccc(CCCO)c(-c3ccc(N(CC)CC)c(C(C)(C)C)c3)c2)cc1.[Na+].[OH-]>>CCN(CC)c1ccc(-c2cc(-c3ccc(C(=O)O)cc3)ccc2CCCO)cc1C(C)(C)C",
        "output": "5"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.O=[N+]([O-])c1cc(Br)cc(Cl)c1O.[Ca+2].[Cl-].[Cl-].[Fe]>>Nc1cc(Br)cc(Cl)c1O",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CI.Cc1cc(CCCCCCCOc2ccc(C3=NCC(CO)O3)cc2)on1.[H-].[Na+]>>COCC1CN=C(c2ccc(OCCCCCCCc3cc(C)no3)cc2)O1",
        "output": "140"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1c(OC(C)C)nc2ccc(Cl)cc2c1Cc1ccccc1Cl.[Na+].[OH-]>>CC(C)Oc1nc2ccc(Cl)cc2c(Cc2ccccc2Cl)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.N#Cc1ccccc1-c1ccc(CN=[N+]=[N-])cc1.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1ccccc1-c1ccc(CN)cc1",
        "output": "562"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)O.Cc1nc(Cl)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1.Cl.N[C@H]1CC[C@H](O)CC1>>Cc1nc(N[C@@H]2CC[C@@H](O)CC2)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1",
        "output": "145"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)OB(c2ccc(-c3cnc(N)c(C#N)n3)c(F)c2)OC1(C)C.O=S(=O)(c1ccccc1Br)C1CC1>>N#Cc1nc(-c2ccc(-c3ccccc3S(=O)(=O)C3CC3)cc2F)cnc1N",
        "output": "933"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1cccnc1Oc1ccc(F)cc1.Cl.[Na+].[OH-]>>O=C(O)c1cccnc1Oc1ccc(F)cc1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cccc(/C=C/c2ccc([N+](=O)[O-])cc2)c1.[Sn]>>COc1cccc(/C=C/c2ccc(N)cc2)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C=CCSCCON=C(C(=O)O)c1csc(NC=O)n1.CC(C)=O.CN(C)C=O.NC1C(=O)N2C(C(=O)O)=CCS[C@H]12.O.O=C([O-])[O-].O=P(Cl)(Cl)Cl.[Na+].[Na+]>>C=CCSCCON=C(C(=O)NC1C(=O)N2C(C(=O)O)=CCS[C@H]12)c1csc(NC=O)n1",
        "output": "587"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCCOC.Cl[Pd]Cl.O.O=Cc1cc(OCC2CC2)c(I)c(C2CC2)c1.OB(O)c1ccc(F)cc1F.[Cs+].[F-]>>O=Cc1cc(OCC2CC2)c(-c2ccc(F)cc2F)c(C2CC2)c1",
        "output": "855"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COc1cc(C(=O)O)ccc1O.O=C([O-])O.O=S(=O)(O)O.[Na+]>>COC(=O)c1ccc(O)c(OC)c1",
        "output": "33"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.COc1ccc([N+](=O)[O-])cc1OCCN.ClCCl.O=C([O-])[O-].[Na+].[Na+]>>COc1ccc([N+](=O)[O-])cc1OCCNC(=O)OC(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.N#Cc1ccc(-n2cccn2)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCc1ccc(-n2cccn2)cc1",
        "output": "175"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#Cc1ccccc1.CCOC(C)=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.I[Cu]I.Nc1cc(Br)ccc1[N+](=O)[O-]>>Nc1cc(C#Cc2ccccc2)ccc1[N+](=O)[O-]",
        "output": "659"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C=Nc1ccc([N+](=O)[O-])cc1.OCc1cccnc1.c1ccccc1>>O=C(Nc1ccc([N+](=O)[O-])cc1)OCc1cccnc1",
        "output": "34"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CNCCNC1.CC#N.Clc1ncccn1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>c1cnc(N2CCCNCC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CCCCNC(=O)N(C)c1cccc(-c2ccc(/C=C(\\OCC)C(=O)OCC)cc2)c1.[Li+].[OH-]>>CCCCNC(=O)N(C)c1cccc(-c2ccc(/C=C(\\OCC)C(=O)O)cc2)c1",
        "output": "122"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=[N+]([O-])c1ccc2[nH]cc(F)c2c1.[Cl-].[NH4+].[Zn]>>Nc1ccc2[nH]cc(F)c2c1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.CCOc1cc2c(C)c(CCOS(C)(=O)=O)c(=O)oc2cc1OC.c1ccc(N2CCNCC2)cc1>>CCOc1cc2c(C)c(CCN3CCN(c4ccccc4)CC3)c(=O)oc2cc1OC",
        "output": "496"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C(=O)c1cc2nccc(Oc3ccc([N+](=O)[O-])cc3F)c2s1.Clc1ccnc2ccsc12.O=[N+]([O-])c1ccc(O)cc1>>O=[N+]([O-])c1ccc(Oc2ccnc3ccsc23)cc1",
        "output": "936"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.COc1ccccc1.Cc1nc(-c2cc3ccc(O)cc3oc2=O)sc1C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>Cc1nc(-c2cc3ccc(O)cc3oc2=O)sc1C(=O)O",
        "output": "569"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cccnc1Nc1ccc(F)cc1.O.[K+].[OH-]>>O=C(O)c1cccnc1Nc1ccc(F)cc1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.O=C(CCCCCCBr)NOCc1ccccc1.O=C([O-])[O-].Oc1ccc2c(c1)[nH]c1ccccc12.[K+].[K+]>>O=C(CCCCCCOc1ccc2c(c1)[nH]c1ccccc12)NOCc1ccccc1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN=C=NCCCN(C)C.CN1CCNCC1.Cl.O=C(O)c1cccc(NC2(Cc3cccc(Cl)c3)C(=O)Nc3cc(Cl)ccc32)c1>>CN1CCN(C(=O)c2cccc(NC3(Cc4cccc(Cl)c4)C(=O)Nc4cc(Cl)ccc43)c2)CC1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCCCC1.CC(C)(CO)[N+](=O)[O-].CCOC(C)=O.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=[Mn](=O)(=O)[O-].[K+].c1ccncc1>>CC(C)(COS(=O)(=O)C(F)(F)F)[N+](=O)[O-]",
        "output": "582"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1c(O)c2ncc(Cc3ccccc3)cc2n(Cc2ccc(S(C)(=O)=O)cc2)c1=O.NC1CC1>>CS(=O)(=O)c1ccc(Cn2c(=O)c(C(=O)NC3CC3)c(O)c3ncc(Cc4ccccc4)cc32)cc1",
        "output": "498"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "N#Cc1ccccc1F.NCCNc1ccccc1>>N#Cc1ccccc1NCCNc1ccccc1",
        "output": "572"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCOC(=O)N(CC(OC)OC)c1ccc(N2CCOCC2)c(F)c1.O.O=C(O)C(F)(F)F>>CCOC(=O)N(CC=O)c1ccc(N2CCOCC2)c(F)c1",
        "output": "234"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN.Cc1ccc(S(=O)(=O)OCC2Cc3cc(-c4ccccc4)cc(-c4cccc(F)c4)c3O2)cc1>>CNCC1Cc2cc(-c3ccccc3)cc(-c3cccc(F)c3)c2O1",
        "output": "853"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.Cl.F[B-](F)(F)F.N[C@@H]1CN2CCC1CC2.O.O=C(O)c1ccc(Br)s1.On1nnc2ccccc21>>O=C(N[C@@H]1CN2CCC1CC2)c1ccc(Br)s1",
        "output": "736"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCc1cc(C(=O)c2ccnn2C)c(Cl)c(Cl)c1O.CCOC(=O)CBr>>C=CCc1cc(C(=O)c2ccnn2C)c(Cl)c(Cl)c1OCC(=O)OCC",
        "output": "123"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.CN(C)C=O.NCCOCCO.On1nnc2ccccc21>>CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCOCCO",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)Oc1ccc(F)nc1.CS(C)=O.Oc1ccc(Br)cc1.[H-].[Na+]>>CC(C)Oc1ccc(Oc2ccc(Br)cc2)nc1",
        "output": "727"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CN(C)C=O.O=[N+]([O-])c1ccc2c(c1)S(=O)(=O)c1ccccc1-2.[Pd]>>Nc1ccc2c(c1)S(=O)(=O)c1ccccc1-2",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.COCCOCCl.ClCCl.OCCc1ccsc1Br>>COCCOCOCCc1ccsc1Br",
        "output": "598"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(C(=O)NN=C(C)c2nn(C)c(-c3ccc(C(C)(C)C)cc3)c2O)cc1Br.Cl.O.[Na+].[OH-]>>CC(=NNC(=O)c1ccc(C(=O)O)c(Br)c1)c1nn(C)c(-c2ccc(C(C)(C)C)cc2)c1O",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)CC(=O)N[C@@H](CC(=O)O)C(=O)O.CC(=O)O.CC(=O)OC(C)=O.CC(=O)[O-].CC(=O)[O-].CCCCOC(C)=O.[Mg+2]>>CC(=O)CC(=O)N[C@H]1CC(=O)OC1=O",
        "output": "436"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cccnc1.Clc1cccnc1Cl.NCCCOc1cccc(CN2CCCCC2)c1>>Clc1cccnc1NCCCOc1cccc(CN2CCCCC2)c1",
        "output": "70"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.Clc1nccc2ccccc12.NCc1ccccc1.O=C([O-])[O-].[Na+].[Na+]>>c1ccc(CNc2nccc3ccccc23)cc1",
        "output": "612"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@]1(C)c3c(C(=O)O)cc(O)cc3S(=O)(=O)C[C@@H]12.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCNCC1.CN1CCOCC1.F[P-](F)(F)(F)(F)F>>CN1CCN(C(=O)c2cc(O)cc3c2[C@]2(C)CC[C@H]4C(C)(C)CCC[C@]4(C)[C@H]2CS3(=O)=O)CC1",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)CCN(c1cccc([N+](=O)[O-])c1)S(C)(=O)=O.[Pd]>>CN(C)CCN(c1cccc(N)c1)S(C)(=O)=O",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc(C#N)c(-c2ccc(C)s2)c(C#N)c1O.COc1cc(C#N)c(Br)c(C#N)c1O.Cc1ccc(B(O)O)s1>>Cc1ccc(-c2c(C#N)cc(O)c(O)c2C#N)s1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1c(Cl)ncc(C(=O)N2CCC(c3ccc(F)cc3)CC2)c1Cl.Cc1ccc(N)cc1C>>Cc1ccc(Nc2c(C(=O)N3CCC(c4ccc(F)cc4)CC3)cnc(Cl)c2C)cc1C",
        "output": "957"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(=O)(=O)c1ccc(Oc2ncnc3c2cnn3C2CCNCC2)cc1.O=C(Cl)CC1CCCCC1.O=C(O)C(F)(F)F>>CS(=O)(=O)c1ccc(Oc2ncnc3c2cnn3C2CCN(C(=O)CC3CCCCC3)CC2)cc1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CO.CS(=O)(=O)Nc1cc([C@@H](O)CN)ccc1O.O=CC1CCN(c2ccc(C(=O)N[C@@H](CC(=O)OCc3ccccc3)C(=O)OCc3ccccc3)cc2)CC1.[BH3-]C#N.[Na+]>>CS(=O)(=O)Nc1cc([C@@H](O)CNCC2CCN(c3ccc(C(=O)N[C@@H](CC(=O)OCc4ccccc4)C(=O)OCc4ccccc4)cc3)CC2)ccc1O",
        "output": "426"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.COCCN1C[C@@H](N)[C@H](c2ccc(F)c(F)c2)C1.Cc1c(-c2nn(C(C)C)c(=O)o2)nn(-c2ccccc2)c1NC(=O)Oc1ccccc1.Cl.Cl.ClCCl>>COCCN1C[C@@H](NC(=O)Nc2c(C)c(-c3nn(C(C)C)c(=O)o3)nn2-c2ccccc2)[C@H](c2ccc(F)c(F)c2)C1",
        "output": "488"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1ccc(NS(=O)(=O)c2cc(-c3cccc(C(=O)O)c3)c(Cl)s2)cc1O.O=C(n1ccnc1)n1ccnc1.c1ccncc1>>COC(=O)c1cccc(-c2cc(S(=O)(=O)Nc3ccc(C(=O)OC)c(O)c3)sc2Cl)c1",
        "output": "33"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)Nc1ccncc1/C=C/c1n[nH]c2ccc(C=O)cc12.O=C(O)C(F)(F)F.[Na+].[OH-]>>Nc1ccncc1/C=C/c1n[nH]c2ccc(C=O)cc12",
        "output": "782"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COCCBr.O=C(NC1CCCC(c2nc3ccccc3[nH]2)C1)c1ccc2c(c1)OCCO2.O=C([O-])[O-].[K+].[K+]>>COCCn1c(C2CCCC(NC(=O)c3ccc4c(c3)OCCO4)C2)nc2ccccc21",
        "output": "495"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.CN(C)C=O.Cl.NCCCC[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O>>CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O",
        "output": "339"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)O.CCCOc1ccc(-c2ncc(C(=O)OC)cn2)c(C(F)(F)F)c1.O>>CCCOc1ccc(-c2ncc(C(=O)O)cn2)c(C(F)(F)F)c1",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Br.BrBr.CC(=O)O.CCNC(=O)Nc1nc2c(s1)C(=O)CCC2>>CCNC(=O)Nc1nc2c(s1)C(=O)C(Br)CC2",
        "output": "82"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=[N+]([O-])c1ccc(F)cc1O.[Pd]>>Nc1ccc(F)cc1O",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(Cl)Cl.CCO.Cc1cc2cc(N)ccc2[nH]1.Cl.FC(F)(F)c1ccc2c(Cl)ccnc2c1>>Cc1cc2cc(Nc3ccnc4cc(C(F)(F)F)ccc34)ccc2[nH]1",
        "output": "115"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCOC(=O)c1cc(Br)nc2c1cnn2C(C)C.CN1CCNCC1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cc(N2CCN(C)CC2)nc2c1cnn2C(C)C",
        "output": "647"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(/C=C/c2c(-c3ccccc3)noc2C)nc1.Cl.O.O.[Li+].[OH-]>>Cc1onc(-c2ccccc2)c1/C=C/c1ccc(C(=O)O)cn1",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=O.CC(=O)O.CCOC(=O)CSc1nc2sc3c(c2c(=O)n1-c1cccc(F)c1)CCNC3.CO.ClCCl.[Na+].[OH-]>>CCOC(=O)CSc1nc2sc3c(c2c(=O)n1-c1cccc(F)c1)CCN(C)C3",
        "output": "217"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)Cc1ccc2nc(Nc3cc(Cc4ccccc4)nc(N[C@@H]4CC[C@@H](O)CC4)n3)sc2c1.CO.N>>NC(=O)Cc1ccc2nc(Nc3cc(Cc4ccccc4)nc(N[C@@H]4CC[C@@H](O)CC4)n3)sc2c1",
        "output": "163"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#CCN1CCCC1.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=C(c1ccc(I)cc1)c1ccc(OC2CCCCO2)cc1.[Cu]I>>O=C(c1ccc(C#CCN2CCCC2)cc1)c1ccc(OC2CCCCO2)cc1",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C([O-])[O-].O=[N+]([O-])O.O=[N+]([O-])O.OCc1c[nH]c(-c2ccccc2)n1.[Na+].[Na+]>>O=Cc1c[nH]c(-c2ccccc2)n1",
        "output": "287"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClC(Cl)Cl.Nc1nccc2cc(F)ccc12.O.O=C1CCC(=O)N1Br>>Nc1ncc(Br)c2cc(F)ccc12",
        "output": "518"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCn1/c(=N/N=c2\\sc3cc(S(=O)(=O)[O-])ccc3n2CC)sc2cc(S(=O)(=O)[O-])ccc21.COc1ccc(C=O)cc1OC.OCC=Cc1ccccc1.On1nnc2ccccc21.[NH4+].[NH4+]>>O=CC=Cc1ccccc1",
        "output": "183"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCBr.CCN(C(C)C)C(C)C.COc1ncc(Cc2c[nH]c(SCc3ccc(Oc4ccc(F)cc4)cc3)nc2=O)cn1.ClCCCl>>CCCn1cc(Cc2cnc(OC)nc2)c(=O)nc1SCc1ccc(Oc2ccc(F)cc2)cc1",
        "output": "327"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNCCN1.O=C(O)C1(c2ccc(OCCCN3CCCC3)cc2)CCCCC1>>O=C(N1CCNCC1)C1(c2ccc(OCCCN3CCCC3)cc2)CCCCC1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)c1ccc2c(c1)NC(=O)CO2.CCO.COC(OC)N(C)C>>CN(C)C=CC(=O)c1ccc2c(c1)NC(=O)CO2",
        "output": "576"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)[N-]C(C)C.CN(C)C=O.COc1ccc(-c2cscc2-c2ccc(C#N)cc2C)cc1.[Li+]>>COc1ccc(-c2csc(C=O)c2-c2ccc(C#N)cc2C)cc1",
        "output": "617"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C(=O)OC(C)(C)C)C1(C)CCC(Oc2ncnc3sc4c(c23)[C@@H](CC#N)CC4)CC1.CO.O.OO.[Li]O>>CN(C(=O)OC(C)(C)C)C1(C)CCC(Oc2ncnc3sc4c(c23)[C@@H](CC(N)=O)CC4)CC1",
        "output": "632"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCn1c(=O)c2c(nc(/C=C/c3ccc(OCOC)c(OC)c3)n2C)n(CCC)c1=O.Cl.O.[Na+].[OH-]>>CCCn1c(=O)c2c(nc(/C=C/c3ccc(O)c(OC)c3)n2C)n(CCC)c1=O",
        "output": "755"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.CN1CCC(c2ccc(Cl)c(Cl)c2)C(C=O)C1.CON.Cl>>CON=CC1CN(C)CCC1c1ccc(Cl)c(Cl)c1",
        "output": "118"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(=O)(=O)c1cc(F)cc(F)c1.Cc1nc2c(Cl)cccc2n1-c1cccc(O)c1>>Cc1nc2c(Cl)cccc2n1-c1cccc(Oc2cc(F)cc(S(C)(=O)=O)c2)c1",
        "output": "564"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COc1ccc2[nH]c(-c3nc(C4CC4)no3)cc2c1.ClCCl.O.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>COc1ccc2[nH]c(-c3nc(C4CC4)no3)c(C=O)c2c1",
        "output": "266"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)c1nn(-c2ccc(C(F)(F)F)nn2)cc1CCCO.CCCCP(CCCC)CCCC.COC(=O)Cc1cccc(C)c1O.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>Cc1cccc(CC(=O)O)c1OCCCc1cn(-c2ccc(C(F)(F)F)nn2)nc1C(C)(C)C",
        "output": "928"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.O=C(O)c1ccc(-c2ccc3c(c2)CCN(C2CCC2)CC3)nc1>>O=C(c1ccc(-c2ccc3c(c2)CCN(C2CCC2)CC3)nc1)N1CCOCC1",
        "output": "256"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC12CC3CC(C1)N(C(=O)OC(C)(C)C)C(C3)C2.ClCCl.O=C(O)C(F)(F)F>>COC12CC3CC(C1)NC(C3)C2",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)c1ccc(N)cc1.CCN=C=NCCCN(C)C.CN(C)C=O.COc1cc2nccc(Oc3ccc(C(=O)O)cc3)c2cc1OC.Cl>>COc1cc2nccc(Oc3ccc(C(=O)Nc4ccc(C(C)(C)C)cc4)cc3)c2cc1OC",
        "output": "50"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCBr.CC(C)=O.CCOC(=O)C(C)c1ccc(O)c([N+](=O)[O-])c1.O=C([O-])[O-].[K+].[K+]>>C=CCOc1ccc(C(C)C(=O)OCC)cc1[N+](=O)[O-]",
        "output": "77"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1cnccc1N1CCC(COc2ccc3c(c2)CN(C(=O)OC(C)(C)C)CC3)CC1.ClC(Cl)Cl.O=C(O)C(F)(F)F>>COC(=O)c1cnccc1N1CCC(COc2ccc3c(c2)CNCC3)CC1",
        "output": "887"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)[O-].CI.Clc1cc2[nH]nc(I)c2cc1Cl.[K+]>>Cn1nc(I)c2cc(Cl)c(Cl)cc21",
        "output": "229"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.O=C(Nc1ccc2c(c1)c(-c1nc3cc(N4CCOCC4)ccc3[nH]1)nn2C1CCCCO1)C1CCC(F)(F)CC1.O=C(O)C(F)(F)F>>O=C(Nc1ccc2[nH]nc(-c3nc4cc(N5CCOCC5)ccc4[nH]3)c2c1)C1CCC(F)(F)CC1",
        "output": "689"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCN(C)C(=O)c1ccc([N+](=O)[O-])cc1.CCO.[Pd]>>CCCN(C)C(=O)c1ccc(N)cc1",
        "output": "28"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#CCNC1=NC(=O)S/C1=C\\C1CCNCC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.CN(C)C=O.Cl.Cl.O=C([O-])O.O=Cc1ccc(C(F)(F)F)cc1Cl.[Na+].[Na+]>>C#CCNC1=NC(=O)S/C1=C\\C1CCN(Cc2ccc(C(F)(F)F)cc2Cl)CC1",
        "output": "567"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CC(=O)Nc1cc(C)cc(F)c1.S=C=S.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)Nc1cc(C)c(C(C)=O)c(F)c1",
        "output": "31"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CNCCN1.CCN1CCc2ncc(Cl)nc2CC1>>CCN1CCc2ncc(N3CCNCC3)nc2CC1",
        "output": "505"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.OC[C@H]1CNCCO1>>CC(C)(C)OC(=O)N1CCO[C@@H](CO)C1",
        "output": "694"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=C(C)C(=O)Cl.Cc1cc(C)nc(C)c1.ClCCl.OCCCCCCCCCCBr>>C=C(C)C(=O)OCCCCCCCCCCBr",
        "output": "320"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)C(C)Oc1ncn(-c2ccc(Cl)cc2Cl)n1.[K+].[OH-]>>CC(Oc1ncn(-c2ccc(Cl)cc2Cl)n1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C=CCOC(=O)O[C@H]1[C@H](OP2(=O)OCc3ccccc3CO2)[C@@H](COCc2ccccc2)O[C@@H](OC[C@H]2O[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](N=[N+]=[N-])[C@@H](O)[C@@H]2OCc2ccccc2)[C@@H]1NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC.CCCCCCCCCCC[C@H](CC(=O)O)OCc1ccccc1.CN(C)c1ccncc1.ClCCl>>C=CCOC(=O)O[C@H]1[C@H](OP2(=O)OCc3ccccc3CO2)[C@@H](COCc2ccccc2)O[C@@H](OC[C@H]2O[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](N=[N+]=[N-])[C@@H](OC(=O)C[C@@H](CCCCCCCCCCC)OCc3ccccc3)[C@@H]2OCc2ccccc2)[C@@H]1NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(C)=O.COc1coc2ccc(OCCCCCCCl)cc2c1=O.O=C([O-])[O-].OC1CCNCC1.[I-].[K+].[K+].[Na+]>>COc1coc2ccc(OCCCCCCN3CCC(O)CC3)cc2c1=O",
        "output": "138"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CO.NC1COc2ccc3c(c2C1)C(=O)NC3.O=CCCc1c[nH]c2c(F)cc(F)cc12.[BH3-]C#N.[Na+]>>O=C1NCc2ccc3c(c21)CC(NCCCc1c[nH]c2c(F)cc(F)cc12)CO3",
        "output": "426"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.CCCCO.CCN(C(C)C)C(C)C.CN1C(C)(C)CC(N)CC1(C)C.O.O=C(Cl)c1ccc(-n2[nH]c3c(nnc4c(F)cccc43)c2=O)cc1>>CN1C(C)(C)CC(NC(=O)c2ccc(-n3[nH]c4c(nnc5c(F)cccc54)c3=O)cc2)CC1(C)C",
        "output": "271"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.F[P-](F)(F)(F)(F)F.NCC(=O)NCC(F)(F)F.O.O=C(O)c1ccc(/C=C/C(c2cc(Cl)c(F)c(Cl)c2)C(F)(F)F)cc1Br.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>O=C(CNC(=O)c1ccc(/C=C/C(c2cc(Cl)c(F)c(Cl)c2)C(F)(F)F)cc1Br)NCC(F)(F)F",
        "output": "718"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.CN(C)C=O.COc1ccc2nc(-c3cc(C)c(OCCBr)c(C)c3)[nH]c(=O)c2c1>>COc1ccc2nc(-c3cc(C)c(OCCN4CCCC4)c(C)c3)[nH]c(=O)c2c1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)c1cnc(COc2cccc(OC(F)(F)F)c2)cn1.O.[Li+].[OH-]>>O=C(O)c1cnc(COc2cccc(OC(F)(F)F)c2)cn1",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N1C2CCC1CNC2.CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)O)cn3)nc2n1C1CCCC1>>CC(=O)N1C2CCC1CN(C(=O)c1ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc1)C2",
        "output": "256"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC=O.ClCCl.O=C(c1ccccc1)C1CCNCC1.[Cl-].[Na+].[Na+].[OH-]>>OC(c1ccccc1)C1CCNCC1",
        "output": "24"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Nc1cccc(-c2cnco2)c1.Nc1nc(-c2cccc(NC(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Cl)n2)s1>>Nc1nc(-c2cccc(NC(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Nc3cccc(-c4cnco4)c3)n2)s1",
        "output": "808"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1ccc(-c2cc(NC(=O)OC(C)(C)C)ccc2C)cc1.Cl>>CCOC(=O)c1ccc(-c2cc(N)ccc2C)cc1",
        "output": "782"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1c(Br)ccc(-c2cnc(N)cn2)c1F.CS(=O)(=O)Nc1ccccc1B(O)O>>COc1c(-c2ccccc2NS(C)(=O)=O)ccc(-c2cnc(N)cn2)c1F",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccccc1.N#CCc1ccc(Br)c(F)c1.O.O=C([O-])[O-].OB(O)c1ccccc1.[Na+].[Na+]>>N#CCc1ccc(-c2ccccc2)c(F)c1",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCCCOc1nc(N)c2nc(OC)n(CCCCBr)c2n1.COCCN>>CCCCOc1nc(N)c2nc(OC)n(CCCCNCCOC)c2n1",
        "output": "147"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNCC1.COC1=C(OC)C(=O)C(Cc2ccc(CCC(=O)O)cc2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2ccc(CCC(=O)N3CCCCC3)cc2)=C(C)C1=O",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.CN1CCN(S(=O)(=O)c2c(Cl)ccc(Nc3c(Cl)c(=O)c3=O)c2O)CC1.COc1ccccc1N.c1ccc(-c2ccccc2)cc1>>COc1ccccc1Nc1c(Nc2ccc(Cl)c(S(=O)(=O)N3CCN(C)CC3)c2O)c(=O)c1=O",
        "output": "510"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(CC(=O)c1ccccc1)[N+](=O)[O-].CO.O.[Cl-].[Fe].[NH4+]>>CC(C)(N)CC(=O)c1ccccc1",
        "output": "226"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#CC1CCCN(C(=O)OC(C)(C)C)C1.CCN(CC)CC.Fc1ccc(I)cc1.[Cu]I>>CC(C)(C)OC(=O)N1CCCC(C#Cc2ccc(F)cc2)C1",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.Cc1ccc(N)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1Cl.O=C=Nc1ccccc1>>Cc1ccc(NC(=O)Nc2ccccc2)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1Cl",
        "output": "473"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(C)=O.O.O=[N+]([O-])c1ccc2snc(Cl)c2c1.[Cl-].[Fe].[NH4+]>>Nc1ccc2snc(Cl)c2c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br.COc1cc(-c2cc(Cl)ccc2C#N)c(C(F)F)cn1.c1cc[nH+]cc1>>N#Cc1ccc(Cl)cc1-c1cc(=O)[nH]cc1C(F)F",
        "output": "758"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCC1CO1.CC(C)(C)OC(=O)Nc1cccc(O)c1.CN(C)C=O.[H-].[Na+]>>CC(C)(C)OC(=O)Nc1cccc(OCC2CO2)c1",
        "output": "18"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c12.Cl.c1ccncc1.c1ccncc1>>Cc1ccc(Oc2ccc(Nc3ncnc4cccc(O)c34)cc2C)cn1",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.CC(C)(C)OC(=O)NCC1CCC(F)CN1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1nc(C(=O)O)c(-c2ccccc2)s1.F[P-](F)(F)(F)(F)F>>Cc1nc(C(=O)N2CC(F)CCC2CNC(=O)OC(C)(C)C)c(-c2ccccc2)s1",
        "output": "747"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C.CN(C)C=O.CN(C)CCCO.CN(C)c1ccncc1.ClCCCl>>CC(=O)N1c2ccc(-c3ccc(C(=O)OCCCN(C)C)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C",
        "output": "33"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CNc1ncc(Cl)nc1C(=O)OC.Cl.ClCCl.[Li+].[OH-]>>CNc1ncc(Cl)nc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN.CO.O=C(O)CCC(=O)O.O=C1c2ccccc2C(=O)N1C[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1>>NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1",
        "output": "242"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cl[Sn]Cl.Cn1nnn(-c2cc(Cl)cc([N+](=O)[O-])c2)c1=O.O.O>>Cn1nnn(-c2cc(N)cc(Cl)c2)c1=O",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)n1cc(B2OC(C)(C)C(C)(C)O2)cn1.Cc1c(Cc2ccc(Br)cc2)c(OC(F)F)nc2c(Cl)ccc(OCC(=O)OC(C)(C)C)c12>>Cc1c(Cc2ccc(-c3cnn(C(C)C)c3)cc2)c(OC(F)F)nc2c(Cl)ccc(OCC(=O)OC(C)(C)C)c12",
        "output": "971"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)CN1CCN(Cc2ccc(Br)cc2)CC1.NN>>NNC(=O)CN1CCN(Cc2ccc(Br)cc2)CC1",
        "output": "164"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=C/C=C(\\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](O)C=C[C@@H]1C.CC(=O)OC(C)=O.CCN(CC)CC.CCOC(C)=O.CN(C)c1ccncc1.ClCCl.O=C([O-])O.[Na+]>>C=C/C=C(\\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)C=C[C@@H]1C",
        "output": "155"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCc1ccc(C#Cc2ccc(C=O)cc2)cc1.COC(=O)c1ccc2c(c1)C(N)CCC2>>CCCCc1ccc(C#Cc2ccc(CNC3CCCc4ccc(C(=O)OC)cc43)cc2)cc1",
        "output": "683"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)C(NC(=O)c1ccc(CN(Cc2ccccn2)S(=O)(=O)c2ccc(Cl)cc2)cc1)c1ccc(F)c(F)c1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li+].[OH-]>>O=C(NC(C(=O)O)c1ccc(F)c(F)c1)c1ccc(CN(Cc2ccccn2)S(=O)(=O)c2ccc(Cl)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)[C@@H]1CCCC[C@@H]1N.CCN(CC)CC.Cl.ClCCl.O=S(=O)(Cl)c1ccc2c(Cl)cnc(Cl)c2c1>>CC(C)(C)OC(=O)[C@@H]1CCCC[C@@H]1NS(=O)(=O)c1ccc2c(Cl)cnc(Cl)c2c1",
        "output": "43"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1sc2ncnc(Nc3ccc(F)cc3O[C@@H]3CCOC3)c2c1C.CO.[Na+].[OH-]>>Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3O[C@@H]3CCOC3)c12",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1[C@@H](O)CC2=O.ClCCl.c1ccncc1>>CC(=O)O[C@H]1CC(=O)[C@@]2(C)CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@H]12",
        "output": "254"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.CCOC(C)=O.COC(=O)c1ccc(C)c(-n2c(C)cc(OCc3ccc(F)cc3CNC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)c(Cl)c2=O)c1.O.[Na+].[OH-]>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)ccc2COc2cc(C)n(-c3cc(C(=O)O)ccc3C)c(=O)c2Cl)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.ClCCCBr.O=C([O-])[O-].O=Cc1ccc(O)cc1.[K+].[K+]>>O=Cc1ccc(OCCCCl)cc1",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(Cl)Cl.CCN(CC)CC.CS(C)=O.ClCCl.O=C(C1CC1)N1CCC(O)CC1.O=C(Cl)C(=O)Cl>>O=C1CCN(C(=O)C2CC2)CC1",
        "output": "87"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)C(c1cc2cc(Cl)ccc2n1Cc1ccccc1)N1C(=O)c2ccccc2C1=O.CCO.NN.O>>CC(C)C(N)c1cc2cc(Cl)ccc2n1Cc1ccccc1",
        "output": "242"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)c1cc2c(cc1C(=O)OC)nc(Nc1nc3ccc(OC(F)(F)F)cc3s1)n2C.[Li+].[OH-]>>CCN(CC)c1cc2c(cc1C(=O)O)nc(Nc1nc3ccc(OC(F)(F)F)cc3s1)n2C",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CS(C)=O.Cc1cnc(-c2cc(Cl)ncc2Cl)c(C)c1.O.OCc1cn2c(n1)CNCC2.[Cs+].[F-]>>Cc1cnc(-c2cc(N3CCn4cc(CO)nc4C3)ncc2Cl)c(C)c1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)O)ccc3C)c(F)c12.NC1(c2ncc(F)cn2)CC1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5ncc(F)cn5)CC4)ccc3C)c(F)c12",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COc1cc(C(N)=O)cc(OC)c1C.Cc1ccccc1.O=S(Cl)Cl>>COc1cc(C#N)cc(OC)c1C",
        "output": "374"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCOC(=O)CCCBr.Cc1ccccc1.Nc1cccc(/C=C/c2nc3ccccc3s2)c1>>CCOC(=O)CCCNc1cccc(/C=C/c2nc3ccccc3s2)c1",
        "output": "273"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCBr.CN(C)C=O.COc1cc2c(Cl)ncnc2cc1O.O=C([O-])[O-].[K+].[K+]>>CCOc1cc2ncnc(Cl)c2cc1OC",
        "output": "75"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCC.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.CSCC[C@H]1CNCCN1C(=O)OC(C)(C)C.Cc1cccc(C(=O)O)c1C.Cl.ClCCl.On1nnc2ccccc21>>CSCC[C@H]1CN(C(=O)c2cccc(C)c2C)CCN1C(=O)OC(C)(C)C",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.COc1ccc2[nH]ccc2c1.O.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>COc1ccc2[nH]cc(C=O)c2c1",
        "output": "266"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1CCCC1=O.COc1ccc2c(c1)CCN(C1CCNCC1)C(=O)N2.Cc1cc(C(=O)c2cc(Cl)nc(OCc3ccccc3)c2)cc2oc(=O)n(C)c12>>COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)c4cc(C)c5c(c4)oc(=O)n5C)cc(OCc4ccccc4)n3)CC1)C(=O)N2",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCN(CC)CC.CI.CO.COc1cccc([C@]23CCN(C)C[C@H]2CCC2(C3)OCCO2)c1>>COc1cccc([C@]23CCN(C)C[C@H]2CCC(=O)C3)c1",
        "output": "251"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)c1ccc(N2CCCCCS2(=O)=O)c(C)c1.O.[Li+].[OH-]>>Cc1cc(C(=O)O)ccc1N1CCCCCS1(=O)=O",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1CC/C=C\\c1cccc(Cl)c1.[Na+].[OH-]>>NCC/C=C\\c1cccc(Cl)c1",
        "output": "242"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNCCN1.CC(C)(C)Nc1cc(Cl)nc(NC(C)(C)C)n1.CCN1CCOCC1>>CC(C)(C)Nc1cc(N2CCNCC2)nc(NC(C)(C)C)n1",
        "output": "162"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cccc(OC)c1C(=O)Cl.Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1.O=C1CC(=O)N(c2ccc(C(=O)O)cc2)c2ccc3ccccc3c2N1>>COc1cccc(OC)c1C(=O)Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1",
        "output": "11"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOc1cc(C(=O)O)cc(OCC)c1-c1ccc(C(=O)OC)cc1.CN(C)C=O.Cl.Cl.NC(=O)c1ccc(-c2ccc3c(c2)C(=O)CC2(CCNCC2)O3)nc1.O.On1nnc2ccccc21>>CCOc1cc(C(=O)N2CCC3(CC2)CC(=O)c2cc(-c4ccc(C(N)=O)cn4)ccc2O3)cc(OCC)c1-c1ccc(C(=O)OC)cc1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2ncc(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)n2)C1.ClCCl.O=C(O)C(F)(F)F>>NC(=O)c1cnc(C2CCNC2)nc1-c1ccc(Oc2ccccc2)cc1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(Cl)nc1.CN(C)C=O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[C-]#N.[C-]#N.[Fe+2].[Pd].[Pd].[Zn+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(C)OC(=O)NCc1ccc(C#N)nc1",
        "output": "726"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)N[C@@H](CC(=O)OCc1ccccc1)C(=O)O.ClCCl.N[C@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)OCc1ccccc1>>CC(C)(C)OC(=O)N[C@@H](CC(=O)OCc1ccccc1)C(=O)N[C@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)OCc1ccccc1",
        "output": "132"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)CCc1nc(Cc2ccc(OCc3nc(-c4ccco4)oc3C)cc2)oc1-c1ccccc1.Cl.O.O.[Li+].[OH-]>>Cc1oc(-c2ccco2)nc1COc1ccc(Cc2nc(CCC(=O)O)c(-c3ccccc3)o2)cc1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COc1c(F)cc2c(ccn2C)c1F.COc1ccc2[nH]cc(CCN)c2c1.O=Cc1cccc(OCCC(F)(F)F)c1.[BH4-].[Na+]>>COc1ccc2[nH]cc(CCNCc3cccc(OCCC(F)(F)F)c3)c2c1",
        "output": "468"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.Cl.Cl.ClC(Cl)Cl.Clc1ccc(-c2nc(C3CCNCC3)n[nH]2)nc1.N#Cc1cccn2c(-c3ccccc3)c(-c3ccc(C=O)cc3)nc12.[Na+]>>N#Cc1cccn2c(-c3ccccc3)c(-c3ccc(CN4CCC(c5n[nH]c(-c6ccc(Cl)cn6)n5)CC4)cc3)nc12",
        "output": "567"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.COc1ccc(CC(NC(=O)OC(C)(C)C)c2nc3ccccc3[nH]2)c(C)c1.Cl.ClCCl.N#N>>COc1ccc(CC(N)c2nc3ccccc3[nH]2)c(C)c1",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.Cc1ccc(C2(O)CCN(Cc3ccccc3)CC2)cc1.[Pd]>>Cc1ccc(C2(O)CCNCC2)cc1",
        "output": "84"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.ClCCl.O=S(=O)(Cl)c1cc(Cl)ccc1C(F)(F)F>>O=S(=O)(c1cc(Cl)ccc1C(F)(F)F)N1CCOCC1",
        "output": "99"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)CC(=O)c2ccc(OS(=O)(=O)C(F)(F)F)cc21.OB(O)c1ccc(F)c(F)c1>>CC1(C)CC(=O)c2ccc(-c3ccc(F)c(F)c3)cc21",
        "output": "825"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)Nc1cncc(Br)c1.CC1(C)OB(c2ccc3c(c2)c(C=O)nn3COCC[Si](C)(C)C)OC1(C)C.CCOC(C)=O.Cl[Pd]Cl.O.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)Nc1cncc(-c2ccc3c(c2)c(C=O)nn3COCC[Si](C)(C)C)c1",
        "output": "938"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.O=C1NCCc2ccc(OCCCCO)nc2N1>>CS(=O)(=O)OCCCCOc1ccc2c(n1)NC(=O)NCC2",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CSc1ccc(Br)cc1.Cc1c(C)c(N2CCNCC2)c(C)c2c1OC(C)C2>>CSc1ccc(N2CCN(c3c(C)c(C)c4c(c3C)CC(C)O4)CC2)cc1",
        "output": "294"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)[S@](=O)N[C@H](CN)c1cc(F)cc(Br)c1.ClCCl>>CC(C)(C)OC(=O)NC[C@@H](N[S@@](=O)C(C)(C)C)c1cc(F)cc(Br)c1",
        "output": "631"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.II.Nc1ccc(C(F)(F)F)cc1.O=S(=O)([O-])[O-].[Ag+].[Ag+]>>Nc1ccc(C(F)(F)F)cc1I",
        "output": "372"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)c1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2Cc2ccc(Br)cc2)cc1.OB(O)c1cccc(C(F)(F)F)c1>>COC(=O)c1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2Cc2ccc(-c3cccc(C(F)(F)F)c3)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCCBr.Cn1cc(-c2cn(COCC[Si](C)(C)C)c3ncc(O)cc23)cn1.O=C([O-])[O-].[K+].[K+]>>CCCOc1cnc2c(c1)c(-c1cnn(C)c1)cn2COCC[Si](C)(C)C",
        "output": "608"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1CCC(C(O)c2ccc(F)cc2)CC1.Cc1ccccc1.O=S(Cl)Cl.[Na+].[OH-]>>CN1CCC(C(=O)c2ccc(F)cc2)CC1",
        "output": "32"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C1CCC(Oc2ccc([N+](=O)[O-])cn2)CC1.CCOC(C)=O.[Pd]>>CCOC(=O)C1CCC(Oc2ccc(N)cn2)CC1",
        "output": "269"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Nc1ccc(S(=O)(=O)Nc2cccc3[nH]ccc23)cc1.Cl.[Na+].[OH-]>>Nc1ccc(S(=O)(=O)Nc2cccc3[nH]ccc23)cc1",
        "output": "66"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Oc1c(C(C)(C)C)cc2c(c1C(C)(C)C)CC(C)(CNC(=N)NN)O2.CC(C)C[Al+]CC(C)C.Cc1ccccc1.[Cl-].[H-].[NH4+]>>CC1(CNC(=N)NN)Cc2c(cc(C(C)(C)C)c(O)c2C(C)(C)C)O1",
        "output": "22"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCc1cn(Cc2ccc3cc(OCc4cccnc4C)ccc3c2)cc1-c1ccccc1.Cl.[Na+].[OH-]>>Cc1ncccc1COc1ccc2cc(Cn3cc(CCC(=O)O)c(-c4ccccc4)c3)ccc2c1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC1(C)OCC(C)(C)[C@H](C(=O)NCCCO)O1.ClCCl>>CC1(C)OCC(C)(C)[C@H](C(=O)NCCC=O)O1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.C1COCCO1.CCOC(=O)c1cc(C(C)=O)nn1-c1ncccc1Cl.COC(C)(C)C.O>>CCOC(=O)c1cc(C(=O)CBr)nn1-c1ncccc1Cl",
        "output": "173"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)CCCCCCCNC(=O)C(CO)NS(=O)(=O)c1ccc(Cl)cc1.CS(=O)(=O)Cl>>COC(=O)CCCCCCCNC(=O)C(COS(C)(=O)=O)NS(=O)(=O)c1ccc(Cl)cc1",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(CCCO)C(=O)OC1c2ccccc2-c2ccccc21.ClCCl.O=C(Cl)C(=O)Cl>>CN(CCC=O)C(=O)OC1c2ccccc2-c2ccccc21",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOCC.COc1cc(C(=O)Cl)cc(OC)c1OC.N#Cc1ccccc1N.O=C([O-])[O-].[K+].[K+]>>COc1cc(C(=O)Nc2ccccc2C#N)cc(OC)c1OC",
        "output": "11"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC1)Oc1ccccc1-n1cccc12.ClCCl.O=C1CCC(=O)N1Br.O=S([O-])([O-])=S.[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCC2(CC1)Oc1ccccc1-n1c(Br)ccc12",
        "output": "779"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNC1.CC(=O)O.CC(C)(C)c1ccc(NC(=O)c2ccc(-c3ncccc3C=O)cc2)cc1.CC(Cl)Cl>>CC(C)(C)c1ccc(NC(=O)c2ccc(-c3ncccc3CN3CCCC3)cc2)cc1",
        "output": "757"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Cc1ccc(-c2cc(CO)nn2-c2ccc(S(N)(=O)=O)cc2)cc1.[Mn+4].[O-2].[O-2]>>Cc1ccc(-c2cc(C=O)nn2-c2ccc(S(N)(=O)=O)cc2)cc1",
        "output": "573"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=C(Nc1nc2cc3c(cc2[nH]1)OC(F)(F)O3)c1cc([N+](=O)[O-])c[nH]1.[Pd]>>Nc1c[nH]c(C(=O)Nc2nc3cc4c(cc3[nH]2)OC(F)(F)O4)c1",
        "output": "269"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C/C=C/C(=O)O)C1CC1.COc1ccc(Cn2nc(N[C@@H]3CCNC3)c3c(Oc4ccc(C(=O)Nc5cc(C#N)ccn5)cc4)ccnc32)cc1.Cl>>COc1ccc(Cn2nc(N[C@@H]3CCN(C(=O)/C=C/CN(C)C4CC4)C3)c3c(Oc4ccc(C(=O)Nc5cc(C#N)ccn5)cc4)ccnc32)cc1",
        "output": "870"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COc1nc(NCCO[Si](C)(C)C(C)(C)C)nc(OC)c1[N+](=O)[O-]>>COc1nc(NCCO[Si](C)(C)C(C)(C)C)nc(OC)c1N",
        "output": "660"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.COC(=O)CBr.C[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C.O=C([O-])[O-].[K+].[K+]>>COC(=O)COc1ccc(C[C@@H](C)NC(=O)OC(C)(C)C)cc1",
        "output": "557"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCC1CC1.CI.O=c1c(-c2ccc(Cl)cc2)c[nH]c2ccnc(NCc3ccccc3)c12>>O=c1c(-c2ccc(Cl)cc2)cn(CC2CC2)c2ccnc(NCc3ccccc3)c12",
        "output": "470"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)Nc1ccc(C2OCCO2)c([N+](=O)[O-])c1.O.O=C(O)C(F)(F)F>>COC(=O)Nc1ccc(C=O)c([N+](=O)[O-])c1",
        "output": "655"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOCC.COc1ccc(OC)c(S(=O)(=O)Cl)c1.NCc1ccccc1Cl>>COc1ccc(OC)c(S(=O)(=O)NCc2ccccc2Cl)c1",
        "output": "530"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NS(=O)(=O)NCc1cccc(Oc2cc(F)c(F)c(Nc3ccc(I)cc3F)c2C(=O)O)c1.CCOC(C)=O.CN(C)C=O.N.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)NS(=O)(=O)NCc1cccc(Oc2cc(F)c(F)c(Nc3ccc(I)cc3F)c2C(N)=O)c1",
        "output": "358"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.NC1CCCCC1.O=C1CCCC(C(=O)O)C1>>O=C1CCCC(C(=O)NC2CCCCC2)C1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CC(=O)N1c2ccc(C#N)cc2[C@H](Nc2cccc(OCCN)n2)[C@@H](C)[C@@H]1C1CC1.ClCCl.c1ccncc1>>CC(=O)NCCOc1cccc(N[C@H]2c3cc(C#N)ccc3N(C(C)=O)[C@@H](C3CC3)[C@@H]2C)n1",
        "output": "45"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)[O-].CC(C)OC(=O)N1CCC(O)CC1.Cc1ncccc1Oc1ncnc(Cl)c1C.[K+]>>Cc1ncccc1Oc1ncnc(OC2CCN(C(=O)OC(C)C)CC2)c1C",
        "output": "461"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)[C@H](C)N.Cl.O=C(O)CC1CCCC1>>COC(=O)[C@H](C)NC(=O)CC1CCCC1",
        "output": "129"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCC(=O)c1ccc(Oc2ccc(C(F)(F)F)cc2)nc1.CCO.[BH4-].[Na+]>>CCCCCCC(O)c1ccc(Oc2ccc(C(F)(F)F)cc2)nc1",
        "output": "449"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "NCc1ccccc1.O=C(O)CC1Cc2cc(Br)cc3[nH]c(=O)c(=O)n1c23>>O=C(CC1Cc2cc(Br)cc3[nH]c(=O)c(=O)n1c23)NCc1ccccc1",
        "output": "599"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N1CCNCC1.CS(=O)(=O)Cc1cc(NC2CCCC2)c2[nH]c(C3=N[C@H](CCI)CS3)cc2c1>>CC(=O)N1CCN(CC[C@@H]2CSC(c3cc4cc(CS(C)(=O)=O)cc(NC5CCCC5)c4[nH]3)=N2)CC1",
        "output": "184"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.N[C@@H]1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C1.O=Cc1ccccn1.[Na+]>>O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CC[C@@H](NCc2ccccn2)C1",
        "output": "775"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C[C@@H](CCO)c1ccc(Cl)c(Cl)c1)C(=O)OC(C)(C)C.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CN(C[C@@H](CC=O)c1ccc(Cl)c(Cl)c1)C(=O)OC(C)(C)C",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)N.Cc1cc(S(=O)(=O)Cl)ccc1Br.ClCCl.O>>Cc1cc(S(=O)(=O)NC(C)(C)C)ccc1Br",
        "output": "43"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)C(=O)O.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCCCC2c2coc3cccc-3c2)CC1>>CC(C)C(=O)N[C@@H]1CC[C@@H](CCN2CCCCC2c2coc3cccc-3c2)CC1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)CCc1ccc(OCc2c(C)c(Cl)cc3cc(CC)oc23)c(C)c1C.Cl.O.[Li+].[OH-]>>CCc1cc2cc(Cl)c(C)c(COc3ccc(CCC(=O)O)c(C)c3C)c2o1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.Cc1ncc(C#N)c(Cl)c1Br.Nc1ccc2cc[nH]c2c1>>Cc1ncc(C#N)c(Nc2ccc3cc[nH]c3c2)c1Br",
        "output": "115"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.O=C(NCC(=O)N1CCNCC1)c1ccc(-c2ccccc2)cc1.O=C(O)c1cc(F)c(Cl)cc1Cl.On1nnc2ccccc21>>O=C(NCC(=O)N1CCN(C(=O)c2cc(F)c(Cl)cc2Cl)CC1)c1ccc(-c2ccccc2)cc1",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(O)c1ccnc(OC)c1OC.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CCC(=O)c1ccnc(OC)c1OC",
        "output": "32"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrP(Br)Br.ClCCl.O=C([O-])O.OCc1cc(C(F)(F)F)ccc1Br.[Na+]>>FC(F)(F)c1ccc(Br)c(CBr)c1",
        "output": "300"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.O=[N+]([O-])c1cccc2nc(N[C@@H]3CCc4ccccc43)ccc12.[H][H].[Pd]>>Nc1cccc2nc(N[C@@H]3CCc4ccccc43)ccc12",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.Cc1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)O)c[nH]c23)c1>>Cc1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)NC4CCN(C(=O)OC(C)(C)C)CC4)c[nH]c23)c1",
        "output": "737"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)c1ccc(-c2cccc(CS(N)(=O)=O)c2)s1.O=C(O)CCCc1ccccc1>>CC(=O)c1ccc(-c2cccc(CS(=O)(=O)NC(=O)CCCc3ccccc3)c2)s1",
        "output": "644"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C[O-].O=[N+]([O-])c1c(F)cc(F)c(F)c1Nc1ccc(Br)cc1F.[Na+]>>COc1cc(F)c(F)c(Nc2ccc(Br)cc2F)c1[N+](=O)[O-]",
        "output": "485"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.Nc1cccc(Br)c1C(=O)O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Nc1cccc(Br)c1CO",
        "output": "72"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc2c(=O)n(COC(=O)C(C)(C)C)cnc2cc1OCC1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>COc1cc2c(=O)n(COC(=O)C(C)(C)C)cnc2cc1OCC1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.ClCCl.NCCc1cc2ccccc2cn1>>CCOC(=O)NCCc1cc2ccccc2cn1",
        "output": "94"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CCF)CCN1C(=O)c2ccccc2C1=O.CCO.NN.O>>CCN(CCN)CCF",
        "output": "242"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCCn1c(=O)c2[nH]c(C34CCC(C(=O)O)(CC3)CC4)nc2n(CCC)c1=O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N>>CCCn1c(=O)c2[nH]c(C34CCC(C(N)=O)(CC3)CC4)nc2n(CCC)c1=O",
        "output": "313"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.O.O=C(Cl)OCc1ccccc1.O=C([O-])[O-].OC1CNC1.[K+].[K+]>>O=C(OCc1ccccc1)N1CC(O)C1",
        "output": "427"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=C(O)c1ccc(Cl)cc1O.O=S(Cl)Cl>>COC(=O)c1ccc(Cl)cc1O",
        "output": "33"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.C[C@H](N)CO.Cc1ccc(-c2cc(C(=O)O)cc(S(C)(=O)=O)c2)cc1.Cl.ClCCl.O.On1nnc2ccccc21>>Cc1ccc(-c2cc(C(=O)N[C@@H](C)CO)cc(S(C)(=O)=O)c2)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1cc2ccccc2n1-c1ccc(OC)cc1.Cl.O.O.[Li+].[OH-]>>COc1ccc(-n2c(C(=O)O)cc3ccccc32)cc1",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)nc1-c1nc(-c2ccccc2)cs1.CO.ClCCl.O=C(O)C(F)(F)F.[NH4+].[OH-]>>CC(C)(C)NC(=O)c1c[nH]nc1-c1nc(-c2ccccc2)cs1",
        "output": "813"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cc(CO)ccc1OCc1nc(-c2ccccc2)oc1C.O=S(Cl)Cl>>COc1cc(CCl)ccc1OCc1nc(-c2ccccc2)oc1C",
        "output": "81"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)NC(=O)[C@@H](N)Cc1ccc(OCc2ccccc2)cc1.CCN(C(C)C)C(C)C.CCOCC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)C1(c2ccccc2)CCCC1>>CC(C)(C)NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)C1(c2ccccc2)CCCC1",
        "output": "133"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.O=Cc1ccc2ccccc2c1O.[H-].[Na+]>>COc1c(C=O)ccc2ccccc12",
        "output": "62"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1cccc(-c2cnc(N)c(C(=O)NC3CC3)n2)c1.[Na+].[OH-]>>Nc1ncc(-c2cccc(C(=O)O)c2)nc1C(=O)NC1CC1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[C@@H](C(=O)O)N1CCN(Cc2ccccc2)C1=O.CCOC(C)=O.CCOP(=O)(OCC)On1nnc2ccccc2c1=O.COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(-c2ccccn2)cc1)C[C@H](O)[C@@H](N)Cc1ccccc1)C(C)(C)C.O=C([O-])[O-].[K+].[K+]>>COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(-c2ccccn2)cc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N1CCN(Cc2ccccc2)C1=O)C(C)(C)C)C(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COc1cc(Cl)ncc1[N+](=O)[O-].O.[Cl-].[Fe].[NH4+]>>COc1cc(Cl)ncc1N",
        "output": "269"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.COc1cccc2c(-c3nc(C)c(CO)s3)cn(CC3CCCCC3)c12.CS(=O)(=O)Cl.ClCCl>>COc1cccc2c(-c3nc(C)c(COS(C)(=O)=O)s3)cn(CC3CCCCC3)c12",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)OC[C@@H](CCn1ccc2ccc(N)cc21)n1cnc(C(N)=O)c1.CCN=C=NCCCN(C)C.ClCCl.O=C(O)CCc1ccccc1.On1nnc2ccccc21>>CC(C)(C)[Si](C)(C)OC[C@@H](CCn1ccc2ccc(NC(=O)CCc3ccccc3)cc21)n1cnc(C(N)=O)c1",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)CBr.CN(C)C=O.N#Cc1cccc(O)c1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)COc1cccc(C#N)c1",
        "output": "393"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.Cc1ccc(O)cc1NC(=O)c1cccc(C2(C#N)CC2)c1.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)nc1.[K+].[K+]>>Cc1ccc(Oc2ccc([N+](=O)[O-])cn2)cc1NC(=O)c1cccc(C2(C#N)CC2)c1",
        "output": "516"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COc1cc2ncnc(Nc3ccccc3)c2c([N+](=O)[O-])c1OC.ClC(Cl)Cl.O.[Cl-].[NH4+].[Zn]>>COc1cc2ncnc(Nc3ccccc3)c2c(N)c1OC",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O.CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.CO.ClCCl.O=C(O)[C@H]([C@H](O)CF)N(OCc1ccccc1)C(=O)O.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)O[C@H](CF)[C@@H](C(=O)O)N(OCc1ccccc1)C(=O)O",
        "output": "193"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCn1cc(-c2ccc(Cl)cc2Cl)nc1/C=C/c1ccc(Br)cc1F.OB(O)c1cccc(O)c1>>CCn1cc(-c2ccc(Cl)cc2Cl)nc1/C=C/c1ccc(-c2cccc(O)c2)cc1F",
        "output": "837"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=N.CN1C(=O)C(c2cccc(-c3ccccc3)c2)(C2CCNCC2)N=C1N.CO.Cl.ClC(Cl)Cl.O=C(O)c1cccs1.[Cl-].[NH4+]>>CN1C(=O)C(c2cccc(-c3ccccc3)c2)(C2CCN(C(=O)c3cccs3)CC2)N=C1N",
        "output": "857"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CN(C)c1ccc(-c2cc(=O)c3c(NCCCCCCBr)c(F)cc(F)c3o2)cc1F.[Cl-].[H-].[NH4+].[Na+].c1c[nH]cn1>>CN(C)c1ccc(-c2cc(=O)c3c(NCCCCCCn4ccnc4)c(F)cc(F)c3o2)cc1F",
        "output": "495"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.C[C@H](NS(=O)(=O)c1cnc2n1[C@](C)(Cc1ccc(C#N)cc1)C(=O)N2c1cc(Cl)cc(Cl)c1)C(=O)O.Cl.F[P-](F)(F)(F)(F)F.NCC(N)=O.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>C[C@H](NS(=O)(=O)c1cnc2n1[C@](C)(Cc1ccc(C#N)cc1)C(=O)N2c1cc(Cl)cc(Cl)c1)C(=O)NCC(N)=O",
        "output": "133"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1cc2c(cn1)COc1c-2ccc(Cl)c1C.CC(C)C[C@@H](CO)NC(=O)OC(C)(C)C>>CC(=O)Nc1cc2c(cn1)COc1c-2ccc(OC[C@H](CC(C)C)NC(=O)OC(C)(C)C)c1C",
        "output": "57"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(CC4CC4)c4ccc(OC(F)F)cc34)nc12.CO.ClCCl.ClCCl.O=C(O)C(F)(F)F>>CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3nn(CC4CC4)c4ccc(OC(F)F)cc34)nc12",
        "output": "981"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.COC(=O)c1nc(Cl)cc(N)c1Br.O.O=C1CCC(=O)N1Cl>>COC(=O)c1nc(Cl)c(Cl)c(N)c1Br",
        "output": "743"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.O=[Mn]=O.O=c1cc(CO)ccn1-c1cccc(Cl)c1>>O=Cc1ccn(-c2cccc(Cl)c2)c(=O)c1",
        "output": "179"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CC(C)O.N#C[C@@]1(C2CC2)CCN(c2ccnc(Cl)n2)C1=O.Nc1cnn(C2(CO)CCC2)c1>>N#C[C@@]1(C2CC2)CCN(c2ccnc(Nc3cnn(C4(CO)CCC4)c3)n2)C1=O",
        "output": "992"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)CO.CN(C)C=O.FC(F)(F)c1cc(Br)ccc1Cl.[H-].[Na+]>>CC(C)(C)COc1ccc(Br)cc1C(F)(F)F",
        "output": "57"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)(CF)C1.CCCCCC.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.O=C(O)CNC(=O)c1cccc(C(F)(F)F)c1>>CC(C)(C)OC(=O)N1CCC(CF)(NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.CN(C)c1ccccn1.N#Cc1ccc(CCO)cc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCc1ccc(C#N)cc1",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.COc1ccc2c(c1)CCN(C(=O)C(F)(F)F)CC2C1CC1.O=C1CCC(=O)N1Br>>COc1cc2c(cc1Br)C(C1CC1)CN(C(=O)C(F)(F)F)CC2",
        "output": "4"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC(C)Cc1ccc(C(C)C(=O)O)cc1.CCCC(=O)[O-].CCCCCCC.CCOC(C)=O.O=C(CCCBr)OCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>CC(C)Cc1ccc(C(C)C(=O)OCCCC(=O)OCc2ccccc2)cc1",
        "output": "416"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC#N.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1C[C@@H](C=O)[C@H](C(C)(C)O[SiH2]C(C)(C)C)C1.CC(C)N.ClCCCl.O.O.[Na+]>>CC(C)NC[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1C(C)(C)O[SiH2]C(C)(C)C",
        "output": "426"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CO.COc1ccccc1-c1cc(C(F)(F)F)no1.ClB(Cl)Cl.ClCCl.O.[I-]>>Oc1ccccc1-c1cc(C(F)(F)F)no1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.CCN(C(C)C)C(C)C.CO.Fc1ccc(-c2cc(Cl)nc(Cl)n2)cc1>>Fc1ccc(-c2cc(N3CCOCC3)nc(Cl)n2)cc1",
        "output": "162"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)[O-].CC(C)=O.CCOC(=O)c1cc2cc([N+](=O)[O-])ccc2[nH]1.O=C([O-])O.[Cl-].[Cl-].[Cl-].[NH4+].[Na+].[Ti+3]>>CCOC(=O)c1cc2cc(N)ccc2[nH]1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1nc2n(c(=O)c1OCc1ccccc1)CCC2(C)C.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)c1nc2n(c(=O)c1O)CCC2(C)C",
        "output": "492"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCO.Nc1ccccc1C(=O)O.O=C([O-])[O-].O=[N+]([O-])c1cc(Cl)ccc1Br.[Cu].[K+].[K+]>>O=C(O)c1ccccc1Nc1ccc(Cl)cc1[N+](=O)[O-]",
        "output": "405"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.Clc1ccc(-c2cc3c(Cl)ncnc3cc2Cl)cc1.NC(=O)CC1CNCCN1>>NC(=O)CC1CN(c2ncnc3cc(Cl)c(-c4ccc(Cl)cc4)cc23)CCN1",
        "output": "296"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C#N)c1ccn2c(Br)cnc2n1.OB(O)c1ccc(F)c(-c2cccnc2)c1>>CC(C)(C#N)c1ccn2c(-c3ccc(F)c(-c4cccnc4)c3)cnc2n1",
        "output": "876"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CCN1C(=O)C(C(=O)OC(C)(C)C)CCc2ccc(OC)cc21.ClC(Cl)Cl.O=C1CCC(=O)N1Br>>CCN1C(=O)C(C(=O)OC(C)(C)C)CCc2cc(Br)c(OC)cc21",
        "output": "4"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC(=O)[O-].COC(=O)Cc1cc2ccc(Cl)cc2c(OS(=O)(=O)C(F)(F)F)c1C.COCCOC.O.O=C([O-])[O-].O=S(=O)(NC1CCCCC1)c1ccc(B(O)O)cc1.[Na+].[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)Cc1cc2ccc(Cl)cc2c(-c2ccc(S(=O)(=O)NC3CCCCC3)cc2)c1C",
        "output": "825"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.NCCc1cccc2c1OCCO2>>CC(=O)NCCc1cccc2c1OCCO2",
        "output": "339"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCc1cc2c(c(-c3ccccc3)c1)OC(CN=[N+]=[N-])C2.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCc1cc2c(c(-c3ccccc3)c1)OC(CN)C2",
        "output": "89"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CO.COc1ccc(S(=O)(=O)N2CCCC2)cc1.ClCCl>>O=S(=O)(c1ccc(O)cc1)N1CCCC1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC#N.CCOC(=O)C1CC(=O)c2cnc(SC)nc2N1C1(CO[Si](C(C)C)(C(C)C)C(C)C)CCCC1.[Na+].[OH-]>>CSc1ncc2c(n1)N(C1(CO[Si](C(C)C)(C(C)C)C(C)C)CCCC1)C(C(=O)O)CC2=O",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCc1ccc(C(F)(F)F)cc1>>COc1cc2nccc(Oc3ccc(NC(=O)OCc4ccc(C(F)(F)F)cc4)c(C)c3C)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cn(Cc2cc(F)cc(F)c2)c2cc(Cl)ccc12.O=C1Cc2ccccc2N1C1CCNCC1>>O=C(c1cn(Cc2cc(F)cc(F)c2)c2cc(Cl)ccc12)N1CCC(N2C(=O)Cc3ccccc32)CC1",
        "output": "256"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COCc1cc(Nc2cc(-c3ccnc(N4CCc5c(cc6n5CCCC6)C4=O)c3C=O)cn(C)c2=O)nn1C.[BH4-].[Na+]>>COCc1cc(Nc2cc(-c3ccnc(N4CCc5c(cc6n5CCCC6)C4=O)c3CO)cn(C)c2=O)nn1C",
        "output": "476"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(CN)c1nc(-c2ccc(F)cc2)n[nH]1.O=C(O)c1cccc(-c2noc(C(F)(F)F)n2)c1>>CC(C)(CNC(=O)c1cccc(-c2noc(C(F)(F)F)n2)c1)c1nc(-c2ccc(F)cc2)n[nH]1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C.CCO.O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1OCc1ccccc1>>O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)C=CC=C(c1ccccc1OC)c1ccccc1OC.[Na+].[OH-]>>COc1ccccc1C(=C/C=C/C(=O)O)c1ccccc1OC",
        "output": "58"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OCCOc1ccc(C)nc1[N+](=O)[O-].CC(C)(C#N)N=NC(C)(C)C#N.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>CC(=O)OCCOc1ccc(CBr)nc1[N+](=O)[O-]",
        "output": "590"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Cc1cc(C)c(-n2c(C)nc3c(NC(=O)CCl)cc(C)nc32)c(C)c1>>Cc1cc(C)c(-n2c(C)nc3c(NCCCl)cc(C)nc32)c(C)c1",
        "output": "112"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)NC(=O)c1cncc(Oc2ccc([N+](=O)[O-])cc2Cl)c1.CCO.O.[Ca+2].[Cl-].[Cl-]>>CC(C)(C)NC(=O)c1cncc(Oc2ccc(N)cc2Cl)c1",
        "output": "335"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(=O)N1c2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)nc2[C@H](Nc2ccccc2)[C@@H](C)[C@@H]1C1CC1.Cl>>CC(=O)N1c2ccc(N3CCNCC3)nc2[C@H](Nc2ccccc2)[C@@H](C)[C@@H]1C1CC1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NCCCO.ClCCl.II.c1c[nH]cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)NCCCI",
        "output": "670"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCCCCCNc1cccc(Sc2ccc(CC(=O)OCC)cc2)c1.CCO.O.[Na+].[OH-]>>CCCCCCCNc1cccc(Sc2ccc(CC(=O)O)cc2)c1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=c1c(-c2ccc([N+](=O)[O-])cc2)coc2cc(O)ccc12.c1ccncc1>>O=c1c(-c2ccc([N+](=O)[O-])cc2)coc2cc(OS(=O)(=O)C(F)(F)F)ccc12",
        "output": "731"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Clc1cccc(Cl)c1CBr.O=Cc1cccc(O)c1.[H-].[Na+]>>O=Cc1cccc(OCc2c(Cl)cccc2Cl)c1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC1CNCCC1Nc1nc(Nc2cn(C)nc2C)ncc1Cl.CCN(CC)CC.CCO.N#Cc1ccc(Cl)nc1>>CCC1CN(c2ccc(C#N)cn2)CCC1Nc1nc(Nc2cn(C)nc2C)ncc1Cl",
        "output": "220"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cl.NO.O.O=Cc1ccc(Br)cc1F.[Na+].[OH-]>>ON=Cc1ccc(Br)cc1F",
        "output": "30"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CCN(CC=C)CC(=O)c1ccc(F)cc1.CC(=O)[O-].CCO.Cl.NO.[Na+]>>C=CCN(CC=C)CC(=NO)c1ccc(F)cc1",
        "output": "212"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCO.Nc1cccc(SCCOc2cccc([N+](=O)[O-])c2)c1>>CC(C)(C)OC(=O)Nc1cccc(SCCOc2cccc([N+](=O)[O-])c2)c1",
        "output": "735"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.C[C@]12CC(=O)[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)O.Cl>>CCOC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.Cl.ClCCl.N#Cc1ccc(N(CC(=O)O)CC(F)(F)F)cc1C(F)(F)F.NC(=NO)c1ccc(F)cc1>>N#Cc1ccc(N(Cc2nc(-c3ccc(F)cc3)no2)CC(F)(F)F)cc1C(F)(F)F",
        "output": "926"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CO.Cc1cc(NCCN)n2nc(C)cc2n1.O=C1CCCC1.[BH3-]C#N.[Na+]>>Cc1cc(NCCNC2CCCC2)n2nc(C)cc2n1",
        "output": "236"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.Cl.O.O=C(O)c1cncc(-c2cccc(O)c2)c1.[Na+].[OH-]>>CC(=O)Oc1cccc(-c2cncc(C(=O)O)c2)c1",
        "output": "46"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4ccc(N5CCN(C(=O)OC(C)(C)C)CC5)c(F)c4)cnc32)cc1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4ccc(N5CCNCC5)c(F)c4)cnc32)cc1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.O=S(=O)(Cl)c1ccccc1.[Na+].[OH-].c1cc[nH]c1>>O=S(=O)(c1ccccc1)n1cccc1",
        "output": "648"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.COc1ccccc1C(C)OC(=O)Nc1c(C)noc1-c1ccc(Br)cc1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4NC(=O)OC(C)c4ccccc4OC)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.CCOC(C)=O.Cc1nn2ccc(OCCN)cc2c1-c1nc(-c2ccccc2)c(-c2nc[nH]n2)s1.Cl.Cl.O=C([O-])O.[Na+]>>CC(=O)NCCOc1ccn2nc(C)c(-c3nc(-c4ccccc4)c(-c4nc[nH]n4)s3)c2c1",
        "output": "339"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)C1=CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1.O>>O=C(O)C1=CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1",
        "output": "58"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1nc(-c2ccnn2C)cs1.O.[K+].[OH-]>>Cn1nccc1-c1csc(C(=O)O)n1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CC(=O)Cl.Cc1cccc(C)n1.ClCCl.O=c1[nH]nc(-c2cc3ccc(F)cc3c(O[C@H]3CCNC3)n2)[nH]1>>C=CC(=O)N1CC[C@H](Oc2nc(-c3n[nH]c(=O)[nH]3)cc3ccc(F)cc23)C1",
        "output": "135"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CC2CNCC1O2.Cl.Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(CC(F)(F)F)c3n2)cc1.O=[N+]([O-])c1ccc(-c2nc(N3C4COCC3COC4)c3cnn(CC(F)(F)F)c3n2)cc1>>Nc1ccc(-c2nc(N3C4COCC3COC4)c3cnn(CC(F)(F)F)c3n2)cc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc(F)c(-c2ncc(CO[Si](C)(C)C(C)(C)C)cc2CC(C)(C)C)c1.O.[F-]>>COc1ccc(F)c(-c2ncc(CO)cc2CC(C)(C)C)c1",
        "output": "708"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCc1ccc(Br)cc1C1C(=O)C(C)(C)OC(C)(C)C1=O.CS(C)=O.Cl.O=P([O-])([O-])[O-].Oc1ccc(Cl)cc1.[Cu]I.[K+].[K+].[K+].c1cnc2c(c1)ccc1cccnc12>>CCc1ccc(Oc2ccc(Cl)cc2)cc1C1C(=O)C(C)(C)OC(C)(C)C1=O",
        "output": "238"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)C1=C[C@@H](CO[Si](C)(C)C(C)(C)C)N(C(=O)OC(C)(C)C)C[C@H]1O.Cl.O.[Li+].[OH-]>>CC(C)(C)OC(=O)N1C[C@@H](O)C(C(=O)O)=C[C@H]1CO[Si](C)(C)C(C)(C)C",
        "output": "58"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.C[Si](C)(C)C=[N+]=[N-].Cc1ccccc1.O=C(O)c1ccc(Nc2cc(N3CCC3)ncn2)cc1>>COC(=O)c1ccc(Nc2cc(N3CCC3)ncn2)cc1",
        "output": "33"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCCC[N+](CCCC)(CCCC)CCCC.COc1cc(C=O)ccc1O.O=C([O-])[O-].OCCCCCCCl.[I-].[K+].[K+]>>COc1cc(C=O)ccc1OCCCCCCO",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1CCCC1.Cl.Clc1nc2ccccc2s1.O.O=[N+]([O-])c1cccnc1NC1CCNCC1>>O=[N+]([O-])c1cccnc1NC1CCN(c2nc3ccccc3s2)CC1",
        "output": "558"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOCC.COC(=O)C1CCNC(Cc2ccc(C(F)(F)F)cc2)C1.COC(=O)Cl.ClCCl>>COC(=O)C1CCN(C(=O)OC)C(Cc2ccc(C(F)(F)F)cc2)C1",
        "output": "219"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCOC(CNC(=O)c2nn(-c3ccc(F)cc3F)c3c2C[C@H]2C[C@@H]32)C1.Cl>>O=C(NCC1CNCCO1)c1nn(-c2ccc(F)cc2F)c2c1C[C@H]1C[C@@H]21",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)n1nc(CO)nc1-c1cn2c(n1)-c1cnc(Cl)cc1OCC2.Cl.FC1(F)CNC1>>CC(C)n1nc(CO)nc1-c1cn2c(n1)-c1cnc(N3CC(F)(F)C3)cc1OCC2",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.O=C(Cl)OCc1cc(Cl)cc(Cl)c1.O=C(NCCC1CCNCC1)c1c[nH]c(=O)o1>>O=C(NCCC1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)c1c[nH]c(=O)o1",
        "output": "427"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.Cc1cn(-c2nc(OCC(F)(F)F)ccc2[N+](=O)[O-])c(CCC(F)(F)F)n1.O=C[O-].[NH4+].[Pd]>>Cc1cn(-c2nc(OCC(F)(F)F)ccc2N)c(CCC(F)(F)F)n1",
        "output": "269"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC1(C)C(=O)C[C@@H](c2cc(F)cc(F)c2)N(CC(=O)[O-])C1=O.Cl.O>>CC1(C)C(=O)C[C@@H](c2cc(F)cc(F)c2)N(CC(=O)O)C1=O",
        "output": "151"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)S(=O)(=O)c1cccc(Br)c1.CCc1nc2c(C#N)cccn2c1-c1cccc(O)c1>>CCc1nc2c(C#N)cccn2c1-c1cccc(Oc2cccc(S(=O)(=O)C(C)C)c2)c1",
        "output": "238"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N1Cc2ccccc2C2(CCN(C3CCC4(CC3)OCCO4)CC2)C1.CC(=O)O.O.[K+].[OH-]>>CC(=O)N1Cc2ccccc2C2(CCN(C3CCC(=O)CC3)CC2)C1",
        "output": "251"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCCCCCCCCCOc1ccc(C(=O)O)cc1.CC[C@H](C)COCCCc1ccc(O)cc1.c1cc(N2CCCC2)ccn1>>CCCCCCCCCCOc1ccc(C(=O)Oc2ccc(CCCOC[C@@H](C)CC)cc2)cc1",
        "output": "355"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCc1cccnc1.O=C([O-])[O-].OO.[Na+].[Na+]>>CCc1ccc[n+]([O-])c1",
        "output": "396"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NNc1ccc(F)cc1F.O=Cc1ccc(O)cc1O>>Oc1ccc(C=NNc2ccc(F)cc2F)c(O)c1",
        "output": "167"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN[C@@H]1CCc2ccc(C(=O)OC)cc21.ClCCl.O=S(=O)(Cl)c1ccccc1Cl>>COC(=O)c1ccc2c(c1)[C@H](N(C)S(=O)(=O)c1ccccc1Cl)CC2",
        "output": "900"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br.CCN(C(C)C)C(C)C.ClCCl.NCCBr.O=S(=O)(Cl)c1ccc(Cl)cc1>>O=S(=O)(NCCBr)c1ccc(Cl)cc1",
        "output": "43"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.N#Cc1cc(-c2ccc(C(F)(F)F)nc2)c(F)cn1.[Ni]>>NCc1cc(-c2ccc(C(F)(F)F)nc2)c(F)cn1",
        "output": "205"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.Cc1cccc2cc[nH]c12.O.[BH3-]C#N.[Na+].[Na+].[OH-]>>Cc1cccc2c1NCC2",
        "output": "672"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1CNCCN1Cc1ccccc1.CI>>CCOC(=O)C1CN(C)CCN1Cc1ccccc1",
        "output": "483"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCI.CCOC(C)=O.CN(C)C=O.Cc1nc(NCCCc2cccc3[nH]ncc23)nc(C)c1C(=O)N[C@@H](CNC(=O)c1cccs1)C(=O)O.O=C([O-])[O-].[K+].[K+]>>CCCCOC(=O)[C@H](CNC(=O)c1cccs1)NC(=O)c1c(C)nc(NCCCc2cccc3[nH]ncc23)nc1C",
        "output": "196"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cl.ClCCl.NNc1ccc(/C=C/C(c2cc(Cl)c(Cl)c(Cl)c2)C(F)(F)F)cc1.O.O=C(Cl)C1CC1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>O=C(NNc1ccc(/C=C/C(c2cc(Cl)c(Cl)c(Cl)c2)C(F)(F)F)cc1)C1CC1",
        "output": "450"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#CCCCC.C#Cc1ccccc1.O=C(OCc1ccccc1)c1cc(OCc2ccccc2)c2cccc(Br)c2n1>>CCCCC#Cc1cccc2c(OCc3ccccc3)cc(C(=O)OCc3ccccc3)nc12",
        "output": "719"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1cc(N)n(-c2ccccc2)n1.O=C(O)Cc1ccc(-n2cnc3cccnc32)cc1>>Cc1cc(NC(=O)Cc2ccc(-n3cnc4cccnc43)cc2)n(-c2ccccc2)n1",
        "output": "795"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCNC(=O)c1cc2nccc(Cl)c2s1.Cc1cc2cc(N)ccc2[nH]1>>CCNC(=O)c1cc2nccc(Nc3ccc4[nH]c(C)cc4c3)c2s1",
        "output": "927"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(C)Br.CN(C)C=O.O=C([O-])[O-].Oc1cccc(C(F)(F)F)c1.[Cs+].[Cs+]>>CCOC(=O)C(C)Oc1cccc(C(F)(F)F)c1",
        "output": "455"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccccc1.C#Cc1ccccc1.C1CCC(NC2CCCCC2)CC1.C1CCOC1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[PH+](C(C)(C)C)C(C)(C)C.Cc1ccccc1.[Cl-].[Na+].[Pd+2].c1ccc([B-](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>C(#Cc1ccccc1)c1ccccc1",
        "output": "659"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)OCc1c(-c2cc(Nc3ccc(N4CCN(C)CC4)cn3)c(=O)n(C)c2)cccc1N1CCn2c(cc3c2CCCC3)C1=O.CC(C)O.O.O.[Li]O>>CN1CCN(c2ccc(Nc3cc(-c4cccc(N5CCn6c(cc7c6CCCC7)C5=O)c4CO)cn(C)c3=O)nc2)CC1",
        "output": "497"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)CCc1ccc(OCc2c(Cl)nsc2-c2ccc(Cl)cc2)c(F)c1F.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCc1ccc(OCc2c(Cl)nsc2-c2ccc(Cl)cc2)c(F)c1F",
        "output": "225"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(C)nc(N)n1.ClCCl.O=C=NS(=O)(=O)c1cc(Cl)sc1Cl>>Cc1cc(C)nc(NC(=O)NS(=O)(=O)c2cc(Cl)sc2Cl)n1",
        "output": "566"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)C(Cc1ccc(OCc2c(Cl)cccc2Cl)cc1)C(=O)Nc1c(OC)cccc1OC.Cl.O.O.[Li]O>>COc1cccc(OC)c1NC(=O)C(Cc1ccc(OCc2c(Cl)cccc2Cl)cc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1nnc2n1CCNC2.O=C(O)c1cc2ncc(Cl)cn2n1>>CCOC(=O)c1nnc2n1CCN(C(=O)c1cc3ncc(Cl)cn3n1)C2",
        "output": "663"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)CCCCCCO.CN(C)C=O.O=C1CCC(=O)N1Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)CCCCCCBr",
        "output": "581"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.Cl.Cl.N.Nc1ccc(F)c(F)c1C(=O)O.On1nnc2ccccc21>>NC(=O)c1c(N)ccc(F)c1F",
        "output": "358"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)N[C@H](C(=O)O)C(C)C.COC(=O)N[C@H]1CCC(=O)N2CCC[C@@H](c3ncc(-c4ccc(-c5cnc6cc(-c7cnc([C@@H]8CCCN8)[nH]7)ccc6n5)cc4)[nH]3)N2C1=O.F[P-](F)(F)(F)(F)F.O.O.[Cl-].[Na+]>>COC(=O)N[C@H]1CCC(=O)N2CCC[C@@H](c3ncc(-c4ccc(-c5cnc6cc(-c7cnc([C@@H]8CCCN8C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]7)ccc6n5)cc4)[nH]3)N2C1=O",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cc1nnc(CNC2CC2)o1.F[B-](F)(F)F.O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1>>Cc1nnc(CN(C(=O)c2ccc(N3CC(F)(F)C3)c(OCC3CC3)n2)C2CC2)o1",
        "output": "605"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CCOCC1.Cc1ccccc1.Nc1ccc(-c2cn3ccnc3c(N)n2)cc1.O=C=Nc1ccccc1>>Nc1nc(-c2ccc(NC(=O)Nc3ccccc3)cc2)cn2ccnc12",
        "output": "473"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCC(C)(c2nc(CO)cs2)CC1.CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)N1CCC(C)(c2nc(COS(C)(=O)=O)cs2)CC1",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COc1ccc(NC(=O)Nc2ccc(F)cc2F)cc1-c1ccn[nH]1.O=C([O-])O.O=C1CCC(=O)N1Br.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>COc1ccc(NC(=O)Nc2ccc(F)cc2F)cc1-c1[nH]ncc1Br",
        "output": "620"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.Nc1nc2ccc(Oc3cccc(C(=O)Nc4ccc(C(F)(F)F)cc4)c3)cc2s1.O.O=C(Cl)C1CC1>>O=C(Nc1ccc(C(F)(F)F)cc1)c1cccc(Oc2ccc3nc(NC(=O)C4CC4)sc3c2)c1",
        "output": "553"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)COC(CCC(O)c2ccc(F)cc2)OC1.CCOCC.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CC1(C)COC(CCC(=O)c2ccc(F)cc2)OC1",
        "output": "32"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C[Si](C)(C)CCOCn1c(O[C@@H]2CO[C@@H]3[C@H](O)CO[C@@H]32)nc2cc(Cl)c(-c3ccc(Br)nc3)nc21.OB(O)c1ccc(Br)cc1>>C[Si](C)(C)CCOCn1c(O[C@@H]2CO[C@@H]3[C@H](O)CO[C@@H]32)nc2cc(Cl)c(-c3ccc(-c4ccc(Br)cc4)nc3)nc21",
        "output": "869"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Cl.CCNCc1cc([N+](=O)[O-])ccc1Oc1cc(CC(=O)OCC)ccc1OC>>CCOC(=O)Cc1ccc(OC)c(Oc2ccc([N+](=O)[O-])cc2CN(CC)C(C)=O)c1",
        "output": "240"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCc1ccccc1.CC#N.CCc1ccc(O)c(OC)c1.O=C([O-])[O-].[K+].[K+]>>CCc1ccc(OCc2ccccc2)c(OC)c1",
        "output": "127"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCO.Cl.O=C(O)Cc1ccc(CC(=O)O)cc1>>CCOC(=O)Cc1ccc(CC(=O)O)cc1",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCCC1CN.O=C(O)c1ccc(Cl)s1>>CC(C)(C)OC(=O)N1CCCC1CNC(=O)c1ccc(Cl)s1",
        "output": "736"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CNC1.COCCOC.Clc1ccncc1Br.O=C([O-])[O-].[Cs+].[Cs+]>>Brc1cnccc1N1CCC1",
        "output": "398"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.CON.Cl.Cl.O=C(CF)CCc1ccc(Cl)cc1.c1ccncc1>>CON=C(CF)CCc1ccc(Cl)cc1",
        "output": "86"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)c1c(C)c(-c2ccccc2)n(S(=O)(=O)c2ccccc2)c1C.Cc1ccccc1.[H-]>>Cc1c(CO)c(C)n(S(=O)(=O)c2ccccc2)c1-c1ccccc1",
        "output": "383"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.OCCCC(F)(F)C(F)(F)F>>O=S(=O)(OCCCC(F)(F)C(F)(F)F)C(F)(F)F",
        "output": "582"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CC(O)CO.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>C=CC(O)COS(=O)(=O)c1ccc(C)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CN(C)C=O.CN1CCCC1=O.Cc1ccc(N)cc1Oc1ccc2nc(NC(=O)C3CC3)cn2n1.N#CC1(c2cccc(C(=O)O)c2)CCC1.O=C(Cl)C(=O)Cl>>Cc1ccc(NC(=O)c2cccc(C3(C#N)CCC3)c2)cc1Oc1ccc2nc(NC(=O)C3CC3)cn2n1",
        "output": "50"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCNC(=O)c1ccc(NC(c2sc3ccccc3c2C)C(CC)CC)cc1.[Na+].[OH-]>>CCC(CC)C(Nc1ccc(C(=O)NCCC(=O)O)cc1)c1sc2ccccc2c1C",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(C)=O.FC(F)(F)Sc1ccc(CBr)cc1.[C-]#N.[Na+]>>N#CCc1ccc(SC(F)(F)F)cc1",
        "output": "39"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)c1ccc(C(=O)O)nc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cn1cc(-c2nc3c(-c4ccc(CN)c(F)c4)ccnc3[nH]2)cn1.F[P-](F)(F)(F)(F)F>>Cn1cc(-c2nc3c(-c4ccc(CNC(=O)c5ccc(C(C)(C)C)cn5)c(F)c4)ccnc3[nH]2)cn1",
        "output": "905"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O.CCOC(=O)c1ccc(C(=O)/C=C/C(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)cc1.CO.O.[Br-].[K+].[Li+].[OH-]>>O=C(O)c1ccc(C(=O)/C=C/C(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)cc1",
        "output": "5"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.COc1ccccc1CO.Cl.ClCCl.O=C1CCNCC1C(c1ccccc1)c1ccccc1>>COc1ccccc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1",
        "output": "765"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.COc1ccc(F)cc1OCCN.CS(C)=O.Fc1ccc2[nH]cc(CCCl)c2c1.O>>COc1ccc(F)cc1OCCNCCc1c[nH]c2ccc(F)cc12",
        "output": "279"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.NCCc1c[nH]c2ccc([N+](=O)[O-])cc12.c1ccncc1>>CC(=O)NCCc1c[nH]c2ccc([N+](=O)[O-])cc12",
        "output": "339"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.N#Cc1c(Cl)nc(NCC2CC2)nc1NCCO.c1ccc(N2CCNCC2)cc1>>N#Cc1c(NCCO)nc(NCC2CC2)nc1N1CCN(c2ccccc2)CC1",
        "output": "162"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(O)c1cncc(B2OC(C)(C)C(C)(C)O2)c1.Cc1nn(C(C)C)cc1-n1c(=O)n(C)c2cnc3ccc(Br)cc3c21>>Cc1nn(C(C)C)cc1-n1c(=O)n(C)c2cnc3ccc(-c4cncc(C(C)(C)O)c4)cc3c21",
        "output": "954"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCc2oc3cc(-n4ccc(OCc5ccc(Cl)cn5)cc4=O)ccc3c2C1.CCOCC.CO.Cl.O=C([O-])O.[Na+]>>O=c1cc(OCc2ccc(Cl)cn2)ccn1-c1ccc2c3c(oc2c1)CCNC3",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C1Nc2ccc(C(F)(F)F)cc2C2CCCC12>>FC(F)(F)c1ccc2c(c1)C1CCCC1C(=S)N2",
        "output": "695"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.CO.O=c1c2c(CCc3ccccc3[N+](=O)[O-])n[nH]c2c2cccnc2n1-c1ccccc1.[C].[Pd]>>Nc1ccccc1CCc1n[nH]c2c1c(=O)n(-c1ccccc1)c1ncccc21",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)CCNc1nc(-c2ccc(C#N)cc2)cs1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)CCNc1nc(-c2ccc(CN)cc2)cs1",
        "output": "175"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)[C@](Cc1ccc(OC)cc1)(N=C=O)N(C)CC(O)CO.Cl.O>>COc1ccc(C[C@](N=C=O)(C(=O)O)N(C)CC(O)CO)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.COc1ccc(C(C)(C=C(Br)Br)CCCc2cccc(Oc3ccccc3)n2)cc1.C[Si](C)(C)Cl.[I-].[Na+]>>CC(C=C(Br)Br)(CCCc1cccc(Oc2ccccc2)n1)c1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(O)C(=O)O.CN(C)C=O.COc1cc(OC)c2c(=O)[nH]c(-c3ncccc3NC3CCNCC3)nc2c1.On1nnc2ccccc21>>COc1cc(OC)c2c(=O)[nH]c(-c3ncccc3NC3CCN(C(=O)C(C)O)CC3)nc2c1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)N(C)c1ccc2c(c1)nc(C(C)(C)O)n2CC1CCOCC1.CI.[H-].[Na+]>>COC(C)(C)c1nc2cc(N(C)C(C)=O)ccc2n1CC1CCOCC1",
        "output": "140"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(=O)N1c2ccc(Br)c(OC3CC3)c2CC[C@@H]1C.CC1(C)OB(c2cnn(C3CC3)c2)OC1(C)C.ClCCl.Cl[Pd]Cl.O=C([O-])[O-].[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(=O)N1c2ccc(-c3cnn(C4CC4)c3)c(OC3CC3)c2CC[C@@H]1C",
        "output": "971"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(O)c(F)c1.CS(C)=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)nc1.[Cs+].[Cs+]>>CC(C)(C)OC(=O)Nc1ccc(Oc2ccc([N+](=O)[O-])cn2)c(F)c1",
        "output": "516"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(CC(=O)O)Cc1ccc2c(c1)OCO2.O=C([O-])[O-].O=P(Cl)(Cl)Cl.[K+].[K+].[Na+].[OH-]>>CC1CC(=O)c2cc3c(cc2C1)OCO3",
        "output": "274"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCCC(N)c1ccccc1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ncc2cc(C(=O)Nc3cc(C(=O)O)ccc3Cl)c(=O)[nH]c2n1.F[P-](F)(F)(F)(F)F>>COc1ncc2cc(C(=O)Nc3cc(C(=O)NC(CCNC(=O)OC(C)(C)C)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1",
        "output": "753"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN1CC(N2CCOCC2)COc2ccc([N+](=O)[O-])cc21.CCO.[Pd]>>CCN1CC(N2CCOCC2)COc2ccc(N)cc21",
        "output": "202"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(NC2CCOc3cccc(C)c32)c2nc(C)c(C)n2c1.[Na+].[OH-]>>Cc1cccc2c1C(Nc1cc(C(=O)O)cn3c(C)c(C)nc13)CCO2",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)C=C(C)C=Cc1ccc(Cl)cc1Cl.CO.Cl.O.[Na+].[OH-]>>CC(C=Cc1ccc(Cl)cc1Cl)=CC(=O)O",
        "output": "122"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC[SiH](CC)CC.CO.O=[N+]([O-])c1cccc(S(=O)(=O)C2CC2)c1.[Pd]>>Nc1cccc(S(=O)(=O)C2CC2)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.ClCCl.Nc1ccn2ncc(C=O)c2c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=Cc1cnn2ccc(NC(=O)C(F)(F)F)cc12",
        "output": "106"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCN(CC)c1nc2ccc(Cl)cc2c(-c2cccc(C(C)C)c2)c1C(=O)OC(C)(C)C.CCOC(C)=O.Cl>>CCN(CC)c1nc2ccc(Cl)cc2c(-c2cccc(C(C)C)c2)c1C(=O)O",
        "output": "569"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)O.CCCCCC.CCOC(=O)CCN(C)C(=O)c1ccc(NC(CC(C)C)c2cc(-c3ccc(OC)nc3)oc2C)cc1>>COc1ccc(-c2cc(C(CC(C)C)Nc3ccc(C(=O)N(C)CCC(=O)O)cc3)c(C)o2)cn1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)/C=C/c1cccc(NC(=O)/C=C/c2ccc3c(c2)OCO3)c1.[Na+].[OH-]>>O=C(O)/C=C/c1cccc(NC(=O)/C=C/c2ccc3c(c2)OCO3)c1",
        "output": "58"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)Cc1nc(Cc2ccccc2)c(C)o1.CCOCC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1oc(CCO)nc1Cc1ccccc1",
        "output": "225"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Nc1c(OS(=O)(=O)c2ccc(C)cc2)cccc1OS(=O)(=O)c1ccc(C)cc1.CC(=O)OC(C)=O.O=S(=O)(O)O.O=[N+]([O-])O>>CC(=O)Nc1c(OS(=O)(=O)c2ccc(C)cc2)cc([N+](=O)[O-])cc1OS(=O)(=O)c1ccc(C)cc1",
        "output": "21"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCCO.CCOC(=O)N=NC(=O)OCC.O=[N+]([O-])c1ccc(O)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)NCCOc1ccc([N+](=O)[O-])cc1",
        "output": "550"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N1CCNCC1.CCOc1cc(F)ccc1[N+](=O)[O-].CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOc1cc(N2CCN(C(C)=O)CC2)ccc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.CC(C)n1cnc2cnc(Nc3ccnc(Cl)n3)cc21.CCN(CC)CC.O.c1n[nH]c2c1CNCC2>>CC(C)n1cnc2cnc(Nc3ccnc(N4CCc5[nH]ncc5C4)n3)cc21",
        "output": "36"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CC1(CCC(Cc2ccc(C(=O)OC)cc2)C(=O)O)CC1.[Cl-].[NH4+]>>CCOC(=O)CC1(CCC(CO)Cc2ccc(C(=O)OC)cc2)CC1",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.O.O=C(O)c1ccc(Br)c(C(F)(F)F)c1.OB(O)c1ccccc1F.[Cs+].[F-].[Pd+2]>>O=C(O)c1ccc(-c2ccccc2F)c(C(F)(F)F)c1",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CN(Cc1ccccc1)C1CN2CCC1CC2.[Pd]>>CNC1CN2CCC1CC2",
        "output": "84"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COc1ccc(Cl)cc1CC#N.C[Si](C)(C)Cl.[BH4-].[Li+]>>COc1ccc(Cl)cc1CCN",
        "output": "246"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.ClCCl.NCc1ccccc1.O=C([O-])O.O=C1CC2(C1)CC(COCc1ccccc1)(COCc1ccccc1)C2.[BH3-]C#N.[Na+].[Na+]>>c1ccc(CNC2CC3(C2)CC(COCc2ccccc2)(COCc2ccccc2)C3)cc1",
        "output": "589"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.C1CCC2=NCCCN2CC1.CC#N.O=Cc1ccc(I)cc1O>>O=Cc1ccc(I)cc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.ClCCl.O=C(O)c1ccc(S)cc1.OCCBr>>O=C(O)c1ccc(SCCO)cc1",
        "output": "124"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "N#CC1(c2ccc(Br)cc2)CCOCC1.O=S(=O)(O)O>>NC(=O)C1(c2ccc(Br)cc2)CCOCC1",
        "output": "8"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COC1CCNCC1.Cl.O=C([O-])[O-].OCc1cccc(-c2cnc(Cl)nc2)c1.[K+].[K+]>>COC1CCN(c2ncc(-c3cccc(CO)c3)cn2)CC1",
        "output": "36"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#C[C@]1(O)CCN(C)C1=O.CCOC(=O)c1nc(-c2cccc(Br)c2)nc2c1CCC2>>CCOC(=O)c1nc(-c2cccc(C#C[C@]3(O)CCN(C)C3=O)c2)nc2c1CCC2",
        "output": "659"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC1CN(Cc2ccccc2)CC(C)(CC)C1O.CO.[H][H].[OH-].[OH-].[Pd+2]>>CCC1CNCC(C)(CC)C1O",
        "output": "84"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCC(NC2CCCCC2)CC1.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1.O=[N+]([O-])c1cccc([N+](=O)[O-])c1CO>>O=[N+]([O-])c1cccc([N+](=O)[O-])c1COS(=O)(=O)c1ccc(C(F)(F)F)cc1",
        "output": "197"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#Cc1ccccn1.CC(=O)N(C)C.CC(C)(C)OC(=O)N1CCN(c2ccc(I)cn2)CC1.CCN(CC)CC.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCN(c2ccc(C#Cc3ccccn3)cn2)CC1",
        "output": "819"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#Cc1cnc2ccc(-c3ccc(C(=O)N4CCN(C)CC4)cc3)nn12.Ic1ccccc1>>CN1CCN(C(=O)c2ccc(-c3ccc4ncc(C#Cc5ccccc5)n4n3)cc2)CC1",
        "output": "664"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)O.CCN(C(C)C)C(C)C.CCOCC.ClCCCl.Cn1cc(N)cn1.FC(F)(F)c1cnc(Cl)nc1Cl.[Cl-].[Cl-].[Zn+2]>>Cn1cc(Nc2ncc(C(F)(F)F)c(Cl)n2)cn1",
        "output": "992"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N.O=C(O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4cccc(Cl)c4)CC3)cn2)cc1>>CC(C)NC(=O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4cccc(Cl)c4)CC3)cn2)cc1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.CNCCO.ClCCl>>CN(CCO)C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)c1ncc(Br)[nH]1.COc1ccccc1.O=C(O)C(F)(F)F>>N[C@@H](Cc1ccccc1)c1ncc(Br)[nH]1",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cl.NCc1ccc(C(=O)O)cc1.O.[Na+].[OH-]>>CC(C)(C)OC(=O)NCc1ccc(C(=O)O)cc1",
        "output": "686"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.ClCCl.F[P-](F)(F)(F)(F)F.Nc1nccs1.O.O=C(Cc1cccs1)Nc1ccc(C(CC2CCCC2)C(=O)O)cc1>>O=C(Cc1cccs1)Nc1ccc(C(CC2CCCC2)C(=O)Nc2nccs2)cc1",
        "output": "681"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCCCCI.CN(C)C=O.COC(=O)c1ccc(C#Cc2ccc(O)c(C34CC5CC(CC(C5)C3)C4)c2)cc1.[H-].[Na+]>>CCCCCCCCCOc1ccc(C#Cc2ccc(C(=O)OC)cc2)cc1C12CC3CC(CC(C3)C1)C2",
        "output": "198"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.COc1ccc(Cl)cc1S(=O)(=O)N1CC(N)C(=O)N2C(Cc3ccc(Cl)cc3)C(=O)N(C(C)C)CC21.ClCCl.O=C(Cl)C1CC1>>COc1ccc(Cl)cc1S(=O)(=O)N1CC(NC(=O)C2CC2)C(=O)N2C(Cc3ccc(Cl)cc3)C(=O)N(C(C)C)CC21",
        "output": "159"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1C(=O)CCC1CN.Clc1ncc(Cl)c(Cl)n1>>CN1C(=O)CCC1CNc1nc(Cl)ncc1Cl",
        "output": "110"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COc1ccc(C(=O)Cl)cc1Cl.OC(c1ccc(OC(F)(F)F)cc1)(c1ccc(OC(F)(F)F)cc1)C1CCNCC1.c1ccncc1>>COc1ccc(C(=O)N2CCC(C(O)(c3ccc(OC(F)(F)F)cc3)c3ccc(OC(F)(F)F)cc3)CC2)cc1Cl",
        "output": "201"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.Cc1cc(F)ccc1CCl.O.[C-]#N.[I-].[K+].[K+]>>Cc1cc(F)ccc1CC#N",
        "output": "38"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(CC)(c1ccc(O)c(C)c1)c1ccc(C(=O)OC)c(C)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CCC(CC)(c1ccc(OS(=O)(=O)C(F)(F)F)c(C)c1)c1ccc(C(=O)OC)c(C)c1",
        "output": "731"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O.O=C(NC(=S)Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1)c1ccccc1.[Na+].[OH-]>>NC(=S)Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1",
        "output": "80"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.COc1ccc(Cc2ccc(C(=O)O)nc2)cc1OC>>O=C(O)c1ccc(Cc2ccc(O)c(O)c2)cn1",
        "output": "19"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cnn(-c2ncc(Cl)cn2)c1.O.[Li+].[OH-]>>O=C(O)c1cnn(-c2ncc(Cl)cn2)c1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)Cl.Nc1ccc(C=CCN2CCC(=C3c4ccccc4C=Cc4ccccc43)CC2)cc1>>COC(=O)Nc1ccc(C=CCN2CCC(=C3c4ccccc4C=Cc4ccccc43)CC2)cc1",
        "output": "102"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.Clc1ncc(-c2nc3c(s2)CCN(C2CCC2)CC3)cn1>>c1nc(N2CCCCC2)ncc1-c1nc2c(s1)CCN(C1CCC1)CC2",
        "output": "36"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CI.CN(C)C=O.O.O=C(CCCSc1ccc(F)cc1)Nc1cccc2cnccc12.[H-].[Na+]>>CN(C(=O)CCCSc1ccc(F)cc1)c1cccc2cnccc12",
        "output": "237"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)Cc1nn(Cc2ccc(NC(=O)c3ccc4ccccc4c3)cc2)c2ccc(F)cc12.Cl.O.O.[Li+].[OH-]>>O=C(O)Cc1nn(Cc2ccc(NC(=O)c3ccc4ccccc4c3)cc2)c2ccc(F)cc12",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCOC(=O)C(C#N)=NOS(C)(=O)=O.CCOC(=O)CN.CCOC(C)=O.CN(C)C=O.Cl.O.O=C(N[C@@H](CSCc1ccccc1)C(=O)O)OCc1ccccc1>>CCOC(=O)CNC(=O)[C@H](CSCc1ccccc1)NC(=O)OCc1ccccc1",
        "output": "107"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(CCC(=O)N1CCNCC1)COc1ccccc1-3.CSC>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CC(CCCN1CCNCC1)COc1ccccc1-3",
        "output": "112"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C(=O)NC(C(=O)N1CCC2C1C(OCc1ccc(F)cc1)CN2C(=O)OC(C)(C)C)C(C)(C)C)N(C)C(=O)OCc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>CC(C(=O)NC(C(=O)N1CCC2NCC(OCc3ccc(F)cc3)C21)C(C)(C)C)N(C)C(=O)OCc1ccccc1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CSc1nn(-c2cccc(C)c2)c2cc(C3=CCN(C(=O)OC(C)(C)C)CC3)ccc12.Cl>>CSc1nn(-c2cccc(C)c2)c2cc(C3=CCNCC3)ccc12",
        "output": "800"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.CCC(O)c1c(C(=O)C(C)C)c2ccc(C(N)=O)cc2n1Cc1ccccc1Cl>>CCC(=O)c1c(C(=O)C(C)C)c2ccc(C(N)=O)cc2n1Cc1ccccc1Cl",
        "output": "456"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)cc1OC.Cl.Cl.ClCCl>>COc1ccc(C2=NN(C3CCN(C(=O)CNC(=O)OC(C)(C)C)CC3)C(=O)C2(C)C)cc1OC",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1cc(Br)c(C(F)(F)F)cc1F.Cl.O.[Li+].[OH-]>>O=C(O)c1cc(Br)c(C(F)(F)F)cc1F",
        "output": "5"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)C(CC(=O)O)c1ccc(Br)cc1.CNOC.Cl>>CON(C)C(=O)CC(c1ccc(Br)cc1)C(C)(C)C",
        "output": "54"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.CC(=O)O.O.O=c1c2ccc(Cl)cc2[nH]c2c(O)nn(CCO)c(=O)c12>>CC(=O)OCCn1nc(O)c2[nH]c3cc(Cl)ccc3c(=O)c2c1=O",
        "output": "17"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.N#Cc1ccccc1CBr.NC(=O)c1cc(-c2ccc(O)cc2)no1.O=C([O-])[O-].[I-].[K+].[K+]>>N#Cc1ccccc1COc1ccc(-c2cc(C(N)=O)on2)cc1",
        "output": "127"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccc(F)cc4C#N)cc3)c2s1.CS(C)=O.ClC(Cl)Cl.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccc(F)cc4-c4noc(=O)[nH]4)cc3)c2s1",
        "output": "979"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN.COc1cc(Br)cc(F)c1[N+](=O)[O-]>>CNc1cc(Br)cc(OC)c1[N+](=O)[O-]",
        "output": "572"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)Oc1ccc(CCBr)cc1.CN1CCCC1=O.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3.O.[K+].[OH-]>>Cc1ccc2c(c1)c1c(n2CCc2ccc(OC(C)(C)C)cc2)CCN(C)C1",
        "output": "470"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1ccc2ccccc2n1.C#CCCCCOCCCCCCBr.C1CCC(NC2CCCCC2)CC1.CC#N.CCOCC.[Cu]I>>BrCCCCCCOCCCCC#Cc1ccc2ccccc2n1",
        "output": "777"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.COC(=O)c1cccc(-c2ccc(C)cc2)c1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COC(=O)c1cccc(-c2ccc(CBr)cc2)c1",
        "output": "29"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCCC(C)=O.Cl.NO.c1ccncc1>>CCCCCCC(C)=NO",
        "output": "86"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccccc4)oc4c(ccc5cnn(CC#N)c54)c3=O)cc2)CCC1.CO>>N#CCn1ncc2ccc3c(=O)c(-c4ccc(C5(N)CCC5)cc4)c(-c4ccccc4)oc3c21",
        "output": "793"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.Cc1cc([N+](=O)[O-])ccc1F.O=C([O-])[O-].O=Cc1cccc(O)c1.[K+].[K+]>>Cc1cc([N+](=O)[O-])ccc1Oc1cccc(C=O)c1",
        "output": "564"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COCCOCCl.COc1ccccc1-c1c[nH]c2ncc(Br)cc12.[H-].[I-].[Na+]>>COCCOCn1cc(-c2ccccc2OC)c2cc(Br)cnc21",
        "output": "712"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)c1ccc(N)cc1.CCCP(=O)=O.CCN(CC)CC.ClCCCl.O=C(O)c1cccc(N2CCc3c(cnc4ccccc34)C2)c1>>CC(C)c1ccc(NC(=O)c2cccc(N3CCc4c(cnc5ccccc45)C3)c2)cc1",
        "output": "50"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCOC(C)=O.Nc1ccc(Cl)cc1.O=C(O)c1cnc(Cl)c(Cl)c1>>O=C(O)c1cnc(Nc2ccc(Cl)cc2)c(Cl)c1",
        "output": "434"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C(=O)O)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCCC1=O.C[C@H](N)[C@H](Oc1ccc2c(cnn2-c2ccc(F)cc2)c1)c1ccc2c(c1)OCCO2.F[P-](F)(F)(F)(F)F.O>>C[C@H](NC(=O)C1(C)CC1)[C@H](Oc1ccc2c(cnn2-c2ccc(F)cc2)c1)c1ccc2c(c1)OCCO2",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(=O)n(C)cc1C(=O)CC(c1ccc(Br)cc1)c1ccccc1C.Cl.NO.O=C([O-])O.[Na+]>>Cc1cc(=O)n(C)cc1/C(CC(c1ccc(Br)cc1)c1ccccc1C)=N/O",
        "output": "966"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)c1ccc(/C=C/c2cccnc2)cc1Nc1ccc(F)cc1.O=C(O)C(F)(F)F>>O=C(O)c1ccc(/C=C/c2cccnc2)cc1Nc1ccc(F)cc1",
        "output": "752"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.OCCOc1cc(F)c(F)cc1F>>CS(=O)(=O)OCCOc1cc(F)c(F)cc1F",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(S(=O)(=O)NC2Cc3ccccc3C2)cc1.Cl.ClCCCl.O=C(Cl)CCl.[Al+3].[Cl-].[Cl-].[Cl-]>>Cc1ccc(S(=O)(=O)NC2Cc3ccc(C(=O)CCl)cc3C2)cc1",
        "output": "31"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)Cc1ccc(N)c(Cl)c1.Cl.Cl[Sn]Cl.O.O.O=N[O-].[Na+]>>COC(=O)Cc1ccc(NN)c(Cl)c1",
        "output": "109"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.C=CCc1ccc2ccccc2c1OCc1ccccc1.CC=C(C)C.O.OO.[Na+].[OH-]>>OCCCc1ccc2ccccc2c1OCc1ccccc1",
        "output": "465"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)N.COc1ccc(-c2cc(=O)n(C)c(=O)n2CC2CO2)cc1OC>>COc1ccc(-c2cc(=O)n(C)c(=O)n2CC(O)CNC(C)(C)C)cc1OC",
        "output": "16"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)S(=O)(=O)c1ccccc1Nc1cc(Cl)ncc1C(F)(F)F.Cc1cc(P(C)(C)=O)ccc1N>>Cc1cc(P(C)(C)=O)ccc1Nc1cc(Nc2ccccc2S(=O)(=O)C(C)C)c(C(F)(F)F)cn1",
        "output": "434"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.O.O=Cc1ccc(C(=O)O)cc1.O=[O+][O-]>>O=C(O)c1ccc(C(=O)O)cc1",
        "output": "384"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.Fc1ccc(OC2CCCCO2)cc1Br.[K+]>>CC1(C)OB(c2cc(OC3CCCCO3)ccc2F)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(=O)(=O)c1ccc(CC(=O)O)cc1.Nn1nc(Sc2ccccc2)c2ccccc2c1=O>>CS(=O)(=O)c1ccc(CC(=O)Nn2nc(Sc3ccccc3)c3ccccc3c2=O)cc1",
        "output": "459"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cccc(-c2scnc2C(=O)O)c1.Cc1nc2sccn2c1C(=O)NC[C@H]1NC[C@@H]2C[C@H]12>>Cc1cccc(-c2scnc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2c(C)nc3sccn23)c1",
        "output": "747"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Clc1ccc2c(Cl)ccnc2c1.O=C(O)c1cccc2cc(O)ccc12>>O=C(O)c1cccc2cc(Oc3ccnc4cc(Cl)ccc34)ccc12",
        "output": "351"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N1CCN(c2ccc(N)nc2)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)Cc1ccc(-c2ccnc(C(F)F)c2)cc1>>CC(=O)N1CCN(c2ccc(NC(=O)Cc3ccc(-c4ccnc(C(F)F)c4)cc3)nc2)CC1",
        "output": "368"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)NCCCN1CC2CNCC(C1)O2.O=C([O-])[O-].OCCCBr.[K+].[K+]>>CC(C)(C)OC(=O)NCCCN1CC2CN(CCCO)CC(C1)O2",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=Cc1cc2nc(C(=O)O)c(NC(=O)OCc3ccccc3)cc2cc1F.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cnccc1N1CCC[C@H](NC(=O)OCc2ccccc2)C1>>C=Cc1cc2nc(C(=O)Nc3cnccc3N3CCC[C@H](NC(=O)OCc4ccccc4)C3)c(NC(=O)OCc3ccccc3)cc2cc1F",
        "output": "776"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)c1cccc(CBr)c1.CN(C)C=O.O.[N-]=[N+]=[N-].[Na+]>>CC(C)(C)c1cccc(CN=[N+]=[N-])c1",
        "output": "643"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1ccccc1.O=S(=O)(Cl)CCCCl.c1ccncc1>>O=S(=O)(CCCCl)Nc1ccccc1",
        "output": "194"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N(C)C.CC(C)C(O)C(C)(C)C(=O)Nc1ccc(Cl)cc1.CI.O.[H-].[Na+]>>COC(C(C)C)C(C)(C)C(=O)Nc1ccc(Cl)cc1",
        "output": "140"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(C(=O)CCl)cc1OC.COc1ccc(OC)c(C(=O)CCl)c1.COc1ccc(OC)c(C(O)CCl)c1>>COc1ccc(C(O)CCl)cc1OC",
        "output": "24"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=CCCCCN.CCN(CC)CC.CCOC(=O)Cl.CCSc1ncc(C(=O)O)s1>>C=CCCCCNC(=O)c1cnc(SCC)s1",
        "output": "534"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)c1cc(-c2ncccn2)ccc1Cl.N>>NC(=O)c1cc(-c2ncccn2)ccc1Cl",
        "output": "67"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cc2ccccc2n1Cc1ccc(C(F)(F)F)cc1.CO.Cl.O.[K+].[OH-]>>O=C(O)c1cc2ccccc2n1Cc1ccc(C(F)(F)F)cc1",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)N1CCc2ccccc2CC1.ClCCl.O=S(=O)(O)Cl>>CC(=O)N1CCc2ccc(S(=O)(=O)Cl)cc2CC1",
        "output": "182"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CN[C@H](CN2CCCC2)C1.CN(C)C=O.ClCCl.N=C=N.O=C(O)c1ccc(OCc2ccccc2)cc1>>O=C(c1ccc(OCc2ccccc2)cc1)N1CCC[C@H]1CN1CCCC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(=O)Br.CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1.CN(C)c1ccncc1>>CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1",
        "output": "442"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#Cc1ccc(-c2ccc(Cl)cc2)nn1.Ic1ccc(OCCN2CCCC2)cc1>>Clc1ccc(-c2ccc(C#Cc3ccc(OCCN4CCCC4)cc3)nn2)cc1",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)c1cc2c(c(-c3cn(C)c(=O)c4[nH]ccc34)c1)OC(C(C)C)C(=O)N2.CO.[BH4-].[Na+]>>CC(O)c1cc2c(c(-c3cn(C)c(=O)c4[nH]ccc34)c1)OC(C(C)C)C(=O)N2",
        "output": "24"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CCOc1ccccc1OC(c1ccccc1)C(O)CO.CS(=O)(=O)Cl.C[Si](C)(C)Cl.Cl>>CCOc1ccccc1OC(c1ccccc1)C(CO)OS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.COc1ccc2[nH]cc(CCCBr)c2c1.CS(C)=O.NC(=O)c1ccc(F)c2c1CC(N)CO2.[Na+].[OH-]>>COc1ccc2[nH]cc(CCCNC3COc4c(F)ccc(C(N)=O)c4C3)c2c1",
        "output": "147"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CSCCN1.Clc1cc2c(Nc3ccc(OCc4ccccc4)cc3)ncnc2cn1>>c1ccc(COc2ccc(Nc3ncnc4cnc(N5CCSCC5)cc34)cc2)cc1",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COCCOCCOc1ccc(Br)cc1.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COCCOCCOc1ccc(B2OC(C)(C)C(C)(C)O2)cc1",
        "output": "942"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.CS(=O)(=O)O.Nc1c([N+](=O)[O-])cc(Br)cc1[N+](=O)[O-]>>CC(=O)Nc1c([N+](=O)[O-])cc(Br)cc1[N+](=O)[O-]",
        "output": "6"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CS(C)=O.N#Cc1ccc(F)cc1Cl.OCCCN1CCCCC1.[H-].[Na+]>>N#Cc1ccc(OCCCN2CCCCC2)cc1Cl",
        "output": "485"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=O.ClCCl.Clc1nc(N2CCOCC2)c2sc(C=C3CCNCC3)cc2n1.O.O=CO>>CN1CCC(=Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1",
        "output": "217"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)n1nc(-c2cc(C(=O)O)cnc2-c2ccccc2)ccc1=O.CO.O=C([O-])O.O=S(=O)(O)O.[Na+]>>COC(=O)c1cnc(-c2ccccc2)c(-c2ccc(=O)n(C(C)C)n2)c1",
        "output": "521"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)C[C@@H]1CC[C@@H](N(CC2CCCC2)CC2CCCC2)[C@H](c2ccc(C(F)(F)F)cc2)O1.CO.Cl.[Na+].[OH-]>>O=C(O)C[C@@H]1CC[C@@H](N(CC2CCCC2)CC2CCCC2)[C@H](c2ccc(C(F)(F)F)cc2)O1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CCC1Cc2c(Cl)cccc2C1=O.CC(=O)O.Cc1ccccc1.Cl.O.[Zn]>>C=CCC1Cc2cccc(Cl)c2C1",
        "output": "92"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.ClCCl.O=Cc1c[nH]c2ncc(Br)cc12.O=S(=O)(Cl)c1ccccc1.O=S(=O)([O-])O.[Na+].[OH-]>>O=Cc1cn(S(=O)(=O)c2ccccc2)c2ncc(Br)cc12",
        "output": "354"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.O=C1CCC(=O)N1Br.O=C1CCc2c(Cl)cccc2N1>>O=C1CCc2c(ccc(Br)c2Cl)N1",
        "output": "4"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(CN(Cc1ccnc2ccccc12)C(=O)[C@@H](N)Cc1ccc(OC(C)(C)C)cc1)OCC.O=C(NCc1ccccc1)NCC1(C(=O)O)CC1>>CCOC(CN(Cc1ccnc2ccccc12)C(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)C1(CNC(=O)NCc2ccccc2)CC1)OCC",
        "output": "133"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)Cc1ccc(F)cc1.NN>>NNC(=O)Cc1ccc(F)cc1",
        "output": "130"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COc1c(Cl)cccc1CC#N.N.[Ni]>>COc1c(Cl)cccc1CCN",
        "output": "246"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1cccc(C)n1.ClCCl.Cn1ccc(N)n1.O=C(Cl)C(=O)Cl.O=C(O)[C@H](CC1CCCC1)N1Cc2c(cccc2C(F)(F)F)C1=O>>Cn1ccc(NC(=O)[C@H](CC2CCCC2)N2Cc3c(cccc3C(F)(F)F)C2=O)n1",
        "output": "795"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br.CCN(CC)CC.ClCCl.NCCBr.O=C(Cl)OCc1ccccc1>>O=C(NCCBr)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCOC(C)=O.Cc1cccc(S(=O)(=O)Cl)c1.Nc1ccccc1NC(=O)Nc1ccccc1>>Cc1cccc(S(=O)(=O)Nc2ccccc2NC(=O)Nc2ccccc2)c1",
        "output": "68"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.N#Cc1cc(Br)ccc1F.O.OCCCc1ccccc1.[H-].[Na+]>>N#Cc1cc(Br)ccc1OCCCc1ccccc1",
        "output": "485"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.CS(=O)(=O)Nc1ccc2c(c1)OCCNCCO2.Cl.O=C1CCCC1.[BH3-]C#N.[Na+]>>CS(=O)(=O)Nc1ccc2c(c1)OCCN(C1CCCC1)CCO2",
        "output": "187"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)C(C)(C)Oc1ccc(OCCC(C)Oc2ccc(OC(F)(F)F)cc2C(=O)c2ccccc2)cc1.[Na+].[OH-]>>CC(CCOc1ccc(OC(C)(C)C(=O)O)cc1)Oc1ccc(OC(F)(F)F)cc1C(=O)c1ccccc1",
        "output": "192"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.N#CC1(c2cccc(C(=O)Nc3cc(O)c(F)cc3F)c2Cl)CC1.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)nc1.[K+].[K+]>>N#CC1(c2cccc(C(=O)Nc3cc(Oc4ccc([N+](=O)[O-])cn4)c(F)cc3F)c2Cl)CC1",
        "output": "516"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.NC(=O)c1cc(-c2ccccc2)cc2c(C3CCN(S(=O)(=O)CCCCl)CC3)n[nH]c12.NC1CCCC1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>NC(=O)c1cc(-c2ccccc2)cc2c(C3CCN(S(=O)(=O)CCCNC4CCCC4)CC3)n[nH]c12",
        "output": "279"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(-c2ccn(CCNC(=O)OC(C)(C)C)c2-c2ccc(C#N)cc2C)cc1.Cl>>COc1ccc(-c2ccn(CCN)c2-c2ccc(C#N)cc2C)cc1",
        "output": "538"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.COC(=O)c1cc(N(Cc2ccc(Br)cc2)C(=O)c2ccc(Oc3ccccc3)cc2)ccc1O>>O=C(O)c1cc(N(Cc2ccc(Br)cc2)C(=O)c2ccc(Oc3ccccc3)cc2)ccc1O",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.O.O=S([O-])OO.O=[N+]([O-])c1cc(Br)ccc1CSc1ccc(F)cc1.[K+]>>O=[N+]([O-])c1cc(Br)ccc1CS(=O)(=O)c1ccc(F)cc1",
        "output": "730"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCCOCCN(CCOCCNC(=O)OC(C)(C)C)CC(=O)OCc1ccccc1.CO>>CC(C)(C)OC(=O)NCCOCCN(CCOCCNC(=O)OC(C)(C)C)CC(=O)O",
        "output": "186"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(=O)CCc1c(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)nc2c(cnn2CC)c1-c1cncc(C)c1.O.[F-]>>CCOC(=O)CCc1c(CO)nc2c(cnn2CC)c1-c1cncc(C)c1",
        "output": "781"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCN(CC[C@H](N)c3ccccc3)CC2)c1.O=S(=O)(Cl)c1ccc(F)cc1>>CC(C)C(=O)Nc1cccc(C2CCN(CC[C@H](NS(=O)(=O)c3ccc(F)cc3)c3ccccc3)CC2)c1",
        "output": "530"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCl.Nc1ccc(Br)cn1.O=C(O)C(CC1CCCC1)c1ccc(S(=O)(=O)C(F)(F)F)cc1.O=C1CCC(=O)N1Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(Nc1ccc(Br)cn1)C(CC1CCCC1)c1ccc(S(=O)(=O)C(F)(F)F)cc1",
        "output": "368"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.CO[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1N.O=C(Cl)OCc1ccccc1.O=C([O-])[O-].[Na+].[Na+]>>CO[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1NC(=O)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(Br)ccc1N.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>Cc1cc(Br)ccc1NC(=O)C(F)(F)F",
        "output": "106"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cc1ccnc(N)c1[N+](=O)[O-].[Ni]>>Cc1ccnc(N)c1N",
        "output": "269"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1c(C(C)C)cc(C=O)cc1C(C)C.O=C1Cc2cc(Br)ccc2N1>>COc1c(C(C)C)cc(C=C2C(=O)Nc3ccc(Br)cc32)cc1C(C)C",
        "output": "439"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CCN(C(C)C)C(C)C.CN(C)C=O.CN1CCNCC1.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(B(O)O)cc1>>CN1CCN(C(=O)c2ccc(B(O)O)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.ClCCl.N#Cc1ncc2cc(CN3CN(c4ccccc4)C4(CCNCC4)C3=O)n(CCC3CCCCC3)c2n1.O=C(O)C(F)(F)F>>CC(=O)N1CCC2(CC1)C(=O)N(Cc1cc3cnc(C#N)nc3n1CCC1CCCCC1)CN2c1ccccc1",
        "output": "369"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)c1nccs1.CCOC(=O)C(=O)OCC.CC[O-].[Na+]>>CCOC(=O)C(=O)CC(=O)c1nccs1",
        "output": "526"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.Cc1ccc(C(=O)c2noc(CSc3ccccc3)n2)cc1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=S([O-])([O-])=S.[Na+].[Na+]>>Cc1ccc(C(=O)c2noc(CS(=O)c3ccccc3)n2)cc1",
        "output": "500"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.CO.C[O-].N#Cc1c(N)cccc1F.[Na+]>>COc1cccc(N)c1C#N",
        "output": "485"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)O.COC(=O)c1ccc2ccn(C3CCNCC3)c2c1.COCCOC.COc1ccc2c(c1CC=O)OC(C)(C)CC2=O>>COC(=O)c1ccc2ccn(C3CCN(CCc4c(OC)ccc5c4OC(C)(C)CC5=O)CC3)c2c1",
        "output": "484"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)I.CN(C)C=O.C[C@H]1CCC[C@@H](C)N1CCNC(=O)[C@@H]1CCCCN1c1nc2ccc(O)cc2o1.[H-].[Na+]>>CC(C)Oc1ccc2nc(N3CCCC[C@H]3C(=O)NCCN3[C@@H](C)CCC[C@H]3C)oc2c1",
        "output": "318"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC1(c2ccc(C=O)cc2)CC1.O=Cc1ccc(C2(COCc3ccccc3)CC2)cc1.[BH4-].[K+]>>OCc1ccc(C2(COCc3ccccc3)CC2)cc1",
        "output": "356"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=P(Cl)(Cl)Cl.O=c1cc2ccccc2n[nH]1>>Clc1cc2ccccc2nn1",
        "output": "537"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1ccc2c(c1)ncn2Cc1ccc(Br)cc1.Cl.O.[Li+].[OH-]>>O=C(O)c1ccc2c(c1)ncn2Cc1ccc(Br)cc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COCCOCOc1cccc(C#N)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COCCOCOc1cccc(CN)c1",
        "output": "175"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Oc1ccc(C#CCCn2ccnn2)cc1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>Oc1ccc(C#CCCn2ccnn2)cc1",
        "output": "754"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC[SiH](CC)CC.COc1cc(C(=O)OC(C)(C)C)cn2nc(NC(CF)c3cccc(Cl)c3)nc12.ClCCl.O=C(O)C(F)(F)F>>COc1cc(C(=O)O)cn2nc(NC(CF)c3cccc(Cl)c3)nc12",
        "output": "569"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl.N.O.O=C(O)C1CCC(OCCCN2CCN(c3cccc4sccc34)CC2)CC1>>NC(=O)C1CCC(OCCCN2CCN(c3cccc4sccc34)CC2)CC1",
        "output": "313"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cl.Cl.NCCCCCCCCCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1.O=C(O)Cc1ccc(O)c(F)c1>>O=C(Cc1ccc(O)c(F)c1)NCCCCCCCCCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.O=C(O)CC(c1cccc(O)c1)C1CC1.O=S(=O)(O)O>>COC(=O)CC(c1cccc(O)c1)C1CC1",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(C)(C)OC(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)O.CC1(C)CC(N)CC(C)(C)N1.CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F>>CC1(C)CC(NC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)OC(C)(C)C)CC(C)(C)N1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.COc1cccc([C@@H](C)OC(=O)Nc2c(C)noc2-c2ccc(Br)cc2)c1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4NC(=O)O[C@H](C)c4cccc(OC)c4)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)C(N)Cc1cc(CP(=O)(OCC)OCC)cc(-c2ccc(Cl)cc2)c1.[Na+].[OH-]>>CCOP(=O)(Cc1cc(CC(N)C(=O)O)cc(-c2ccc(Cl)cc2)c1)OCC",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CCOC(C)=O.Cc1c(C)c2c(c(C)c1NC(=O)CC(C)(C)C)C(c1cccc(C3OCCO3)c1)CO2.Cc1ccc(S(=O)(=O)O)cc1.O.c1cc[nH+]cc1>>Cc1c(C)c2c(c(C)c1NC(=O)CC(C)(C)C)C(c1cccc(C=O)c1)CO2",
        "output": "655"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)N1Cc2cc(F)c(Cl)nc2C=Cc2ccc(Cl)cc21.CC1(C)OB(c2ccc(N3CCOCC3)nc2)OC1(C)C.COc1ccc(-c2nc3c(cc2F)CN(C(C)=O)c2ccccc2C=C3)cn1>>CC(=O)N1Cc2cc(F)c(-c3ccc(N4CCOCC4)nc3)nc2C=Cc2ccc(Cl)cc21",
        "output": "968"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCOC(C)=O.O=C1CCC(=O)N1Br.c1cncc(-n2cccn2)c1>>Brc1cnn(-c2cccnc2)c1",
        "output": "620"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COC(=O)c1ccccc1Cc1ccc(OC)cc1[N+](=O)[O-].COc1ccc(I)c([N+](=O)[O-])c1.ClCCl.O>>COC(=O)c1ccccc1Cc1ccc(O)cc1[N+](=O)[O-]",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.ClCc1ccc(Cl)c(Cl)c1.O=C(NCC1CNCCO1)C(F)(F)F.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>O=C(NCC1CN(Cc2ccc(Cl)c(Cl)c2)CCO1)C(F)(F)F",
        "output": "156"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)c1ccc2nc(Cl)[nH]c2c1.Clc1cncc(Cl)c1N1CCNCC1>>CC(C)(C)c1ccc2nc(N3CCN(c4c(Cl)cncc4Cl)CC3)[nH]c2c1",
        "output": "36"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN1CCOCC1.O=C([O-])O.O=C1Nc2ccc(O)cc2Sc2ccccc21.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[Li+].[NH4+].[Na+]>>Oc1ccc2c(c1)Sc1ccccc1CN2",
        "output": "215"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)Cn1c(C#N)c(-c2ccccc2)c2cc(Br)ccc2c1=O.[Co].[H][H].[NH4+].[OH-]>>CC(C)Cn1c(CN)c(-c2ccccc2)c2cc(Br)ccc2c1=O",
        "output": "205"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)CC(C)C.Fc1ccc2c(C3CCNCC3)n[nH]c2c1.O=C([O-])[O-].OCCCBr.[K+].[K+]>>OCCCN1CCC(c2n[nH]c3cc(F)ccc23)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN.CCN=C=NCCCN(C)C.CCOC(C)=O.CN1CCCC1=O.CN1CCOCC1.Cc1cc(F)ccc1-c1nc(NCC(=O)O)nc2c1ccc(=O)n2-c1c(F)cccc1F.Cl>>CCNC(=O)CNc1nc(-c2ccc(F)cc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.COc1ccc2[nH]ccc2c1.Cl.O.O=C1CCNCC1.[K+].[OH-]>>COc1ccc2[nH]cc(C3=CCNCC3)c2c1",
        "output": "607"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)C(C)(C)Oc1ccc(OCCc2nc(-c3ccccc3)oc2C)cc1Cc1ccccc1.CO.[Na+].[OH-]>>Cc1oc(-c2ccccc2)nc1CCOc1ccc(OC(C)(C)C(=O)O)c(Cc2ccccc2)c1",
        "output": "192"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NCCCN1C(=O)c2cc([N+](=O)[O-])ccc2CC1c1ccc(C#N)cc1.CO.O=C1NCCc2ccc([N+](=O)[O-])cc21.[H][H].[Pd]>>Nc1ccc2c(c1)C(=O)NCC2",
        "output": "489"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC[SiH](CC)CC.COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.Cc1ccc(C=O)c2ccccc12.O=C(O)C(F)(F)F>>COc1cc(O)c2c(c1C(=O)NCc1ccc(C)c3ccccc13)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C",
        "output": "996"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OB(c2ccc(N)nc2)OC1(C)C.Cc1cc(-c2ccc(Cl)c(Cl)c2)nc(-c2cccc(Br)c2)n1>>Cc1cc(-c2ccc(Cl)c(Cl)c2)nc(-c2cccc(-c3ccc(N)nc3)c2)n1",
        "output": "954"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1nc(N)sc1-c1ccncc1.CO.O.[Na+].[OH-]>>Nc1nc(C(=O)O)c(-c2ccncc2)s1",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.NS(=O)(=O)c1ccc(NCCCNC2CC2)c([N+](=O)[O-])c1.O=C1CCC1.[Na+]>>NS(=O)(=O)c1ccc(NCCCN(C2CCC2)C2CC2)c([N+](=O)[O-])c1",
        "output": "187"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNC1.CC#N.O=C([O-])[O-].OCCCCl.[K+].[K+]>>OCCCN1CCCC1",
        "output": "138"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1c(C)cc(C(=O)CC(c2ccc(Br)cc2)c2ccccc2C)cc1C.ClCCl>>Cc1ccccc1C(CC(=O)c1cc(C)c(O)c(C)c1)c1ccc(Br)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(C)=O.Cl.O=Cc1ccc(F)cc1.Oc1ccc2c(c1)OCO2.[H-].[Na+]>>O=Cc1ccc(Oc2ccc3c(c2)OCO3)cc1",
        "output": "564"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CSc1ccc(N)cc1.O=C(O)c1cc([N+](=O)[O-])c(Sc2c(Cl)cncc2Cl)s1>>CSc1ccc(NC(=O)c2cc([N+](=O)[O-])c(Sc3c(Cl)cncc3Cl)s2)cc1",
        "output": "822"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCNC(=O)NOCC(=O)O.CCOC(OCC)[C@H](C)N(Cc1csc2ccccc12)C(=O)[C@@H](N)Cc1ccc(OC(C)(C)C)cc1>>CCNC(=O)NOCC(=O)N[C@@H](Cc1ccc(OC(C)(C)C)cc1)C(=O)N(Cc1csc2ccccc12)[C@@H](C)C(OCC)OCC",
        "output": "133"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)Cn1cccc(O)c1=O.O.O=CO>>O=C(O)Cn1cccc(O)c1=O",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N(CCN)C(C)C.CCN(CC)CC.COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.ClC(Cl)Cl.O.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3cc(C)c(NC(=O)NCCN(C(C)C)C(C)C)cc3C)c2cc1OC",
        "output": "913"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cccc2c1Oc1cc(Br)ccc1C2C1CCN(C(=O)C(F)(F)F)CC1.COc1cccc2c1Sc1cc(Br)ccc1C2C1CCN(C(=O)C(F)(F)F)CC1>>COc1cccc2c1Sc1cc(Br)ccc1C2C1CCNCC1",
        "output": "703"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccnc2[nH]ccc12.CN(C)C=O.C[Si](C)(C)CCOCCl.[H-].[Na+]>>C[Si](C)(C)CCOCn1ccc2c(Br)ccnc21",
        "output": "712"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1c(-c2cncc(S(C)(=O)=O)c2)nc2cc(F)cc(F)c2c1Cl.Cc1ccccc1.Nc1cc(N2CCOCC2)cnc1N1CCOCC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1c(-c2cncc(S(C)(=O)=O)c2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)cnc1N1CCOCC1",
        "output": "859"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.Cl.ClCCl.N[C@H]1CCCC[C@@H]1O.O.O=C(O)c1c[nH]c2c(F)c(F)c(F)c(F)c12>>O=C(N[C@H]1CCCC[C@@H]1O)c1c[nH]c2c(F)c(F)c(F)c(F)c12",
        "output": "674"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O.O=C([O-])[O-].OB(O)c1ccc(C(F)(F)F)cc1.Oc1cccc(I)c1.[K+].[K+].[Pd]>>Oc1cccc(-c2ccc(C(F)(F)F)cc2)c1",
        "output": "855"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.COc1ccnc(CN2C(=O)c3ccccc3C2=O)c1.Cl.O.[Br-].[Na+]>>O=C1c2ccccc2C(=O)N1Cc1cc(O)ccn1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)C1CCN(C2CCN(C(=O)[C@@H](Cc3cc(Cl)c(N)c(C(F)(F)F)c3)OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)CC1.Cl.O.[Li+].[OH-]>>Nc1c(Cl)cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCC(C(=O)O)CC3)CC2)cc1C(F)(F)F",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)ON=O.CCOC(=O)c1cc2c(Oc3cc(C)ccc3N)cccc2[nH]1.CCOCC.CN(C)C=O>>CCOC(=O)c1cc2c(Oc3cccc(C)c3)cccc2[nH]1",
        "output": "324"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4ccc(C5CCNCC5)cc4)cnc32)cc1.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4cnc(N5CCN(C)CC5)c(F)c4)cnc32)cc1.Cl.O.[Li+].[OH-]>>CN1CCN(c2ncc(-c3cnc4[nH]cc(-c5cnn(Cc6cccc(F)c6)c5)c4c3)cc2F)CC1",
        "output": "949"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.N#Cc1ccc(-n2cnc3c([N+](=O)[O-])cccc32)cc1.[Pd]>>N#Cc1ccc(-n2cnc3c(N)cccc32)cc1",
        "output": "269"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CC1CC1.C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O.Cn1cnnc1C(=NOCc1cccc(Br)n1)c1ccccc1.I[Cu]I.N#N.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Cn1cnnc1C(=NOCc1cccc(C#CC2CC2)n1)c1ccccc1",
        "output": "777"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CN1CCOCC1.Nc1ccc(Br)cc1N.O.O=C(Cl)C=CC1CCC2(CC1)OCCO2>>Nc1cc(Br)ccc1NC(=O)C=CC1CCC2(CC1)OCCO2",
        "output": "10"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCc1nnc2c(=O)[nH]c3cc(C(=O)O)ccc3n12.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCNCC1c1ccccc1.Cl.Cl.Cl.O.O=C([O-])O.On1nnc2ccccc21.[Cl-].[Na+].[Na+]>>CCCc1nnc2c(=O)[nH]c3cc(C(=O)N4CCN(C)C(c5ccccc5)C4)ccc3n12",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c3c(c12)CC(CO)O3.CS(=O)(=O)Cl.ClCCl>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c3c(c12)CC(COS(C)(=O)=O)O3",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClC(Cl)Cl.ClCCl.c1ccc(CN2C[C@H]3NCCC[C@H]3C2)cc1>>CC(=O)N1CCC[C@H]2CN(Cc3ccccc3)C[C@H]21",
        "output": "125"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCOCc1cc(NS(=O)(=O)c2ccccc2)cc(-c2ccc(C(=O)O)cc2)c1.CCOC(C)=O.CN(C)C=O.Cl.ClCCCl.NO.On1nnc2ccccc21>>CCCOCc1cc(NS(=O)(=O)c2ccccc2)cc(-c2ccc(C(=O)NO)cc2)c1",
        "output": "741"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.OCc1c[nH]c(-c2cccc(F)c2F)n1.[Mn+4].[O-2].[O-2]>>O=Cc1c[nH]c(-c2cccc(F)c2F)n1",
        "output": "287"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COc1ccc(Cl)cc1C[C@H](CNC(=O)OC(C)(C)C)C(=O)O.N.O.O=C(n1ccnc1)n1ccnc1>>COc1ccc(Cl)cc1C[C@H](CNC(=O)OC(C)(C)C)C(N)=O",
        "output": "313"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CCOc1ccc2ccccc2c1CO.Cc1ccccc1.O.O=S(Cl)Cl>>CCOc1ccc2ccccc2c1CCl",
        "output": "81"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.Cc1cccc(C(=O)O)n1.ClCCl.NC1CCCc2c1[nH]c1ccc(Cl)cc21.O>>Cc1cccc(C(=O)NC2CCCc3c2[nH]c2ccc(Cl)cc32)n1",
        "output": "137"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "N#Cc1cccc(C(=O)O)c1.NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1>>N#Cc1cccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "B#B.O=C(CCCCCBr)Nc1ccccc1O>>Oc1ccccc1NCCCCCCBr",
        "output": "112"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cc(C2CC2)c2c(C)c(Cl)c(F)cn2c1=O.N#Cc1ccc(B(O)O)cc1>>CCOC(=O)c1cc(C2CC2)c2c(C)c(-c3ccc(C#N)cc3)c(F)cn2c1=O",
        "output": "947"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=[Cr](=O)([O-])Cl.OCCCc1ccc(Cl)c(F)c1.c1cc[nH+]cc1>>O=CCCc1ccc(Cl)c(F)c1",
        "output": "142"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(C)=O.O=[N+]([O-])c1ccc(F)c(-c2ccncc2)c1.O=[Pt]=O>>Nc1ccc(F)c(-c2ccncc2)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.Cc1ccc2c(c1)c1c(n2CC(O)c2ccncc2)CCNC1.ClCCl>>CCOC(=O)N1CCc2c(c3cc(C)ccc3n2CC(O)c2ccncc2)C1",
        "output": "219"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(C(=O)N(C)C2CNCC2c2ccc(Cl)cc2)cc1C(F)(F)F.Cc1cc(F)ccc1C(=O)O>>COc1ccc(C(=O)N(C)C2CN(C(=O)c3ccc(F)cc3C)CC2c2ccc(Cl)cc2)cc1C(F)(F)F",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Cc1nc[nH]c1C.Clc1cccc(Oc2ccc(CBr)cc2)c1.[H-].[Na+]>>Cc1ncn(Cc2ccc(Oc3cccc(Cl)c3)cc2)c1C",
        "output": "593"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1CCC(C(=O)N(c2cc(-c3ccccc3)sc2C(=O)O)C(C)CN=[N+]=[N-])CC1.CCO.[Pd]>>CC1CCC(C(=O)N(c2cc(-c3ccccc3)sc2C(=O)O)C(C)CN)CC1",
        "output": "89"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "NC1CCOCC1.O=C(O)c1n[nH]c2cccc(F)c12>>O=C(NC1CCOCC1)c1n[nH]c2cccc(F)c12",
        "output": "816"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Oc1ccc(C(C)ON2C(C)(C)CC3(CC2(C)C)OCC(C)(C)CO3)cc1.CO.Cl.O.O=C([O-])[O-].[K+].[K+]>>CC(ON1C(C)(C)CC2(CC1(C)C)OCC(C)(C)CO2)c1ccc(O)cc1",
        "output": "22"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.COc1ccc(C=O)cc1O.ClCc1ccccc1.O.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>COc1ccc(C=O)cc1OCc1ccccc1",
        "output": "49"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccccc3)n2)c1.O=C(O)Cc1cccc(Cl)c1.O=C(n1ccnc1)n1ccnc1>>O=C(Cc1cccc(Cl)c1)Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccccc3)n2)c1",
        "output": "365"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.COc1cc(Cl)c(C#N)cc1-c1nccc2cc(S(=O)(=O)Nc3ncccn3)ccc12.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.O.O=P([O-])([O-])[O-].OB(O)c1cccc(C(F)(F)F)c1.[K+].[K+].[K+]>>COc1cc(-c2cccc(C(F)(F)F)c2)c(C#N)cc1-c1nccc2cc(S(=O)(=O)Nc3ncccn3)ccc12",
        "output": "892"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ncc(CN)c2c1OC(C)(C)OC2.N#Cc1ccc(C(=O)O)cc1>>Cc1ncc(CNC(=O)c2ccc(C#N)cc2)c2c1OC(C)(C)OC2",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCC(C)(C)CO)cc1CC2CC.Cl.[Na+].[OH-]>>CCC1Cc2cc(OCC(C)(C)CO)c(OC)cc2-c2cc(=O)c(C(=O)O)cn21",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.Clc1ccc2[nH]ccc2c1.O=C1CCN2CCCC2C1>>Clc1ccc2[nH]cc(C3=CCN4CCCC4C3)c2c1",
        "output": "607"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)C1CCN(C)CC1.CCOCC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CN1CCC(CO)CC1",
        "output": "225"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCCCCCCCCCCCCCCCCCC(=O)O.CCN(CC)CC.CCN(CC)CCOCCO.ClCCl>>CCCCCCCCCCCCCCCCCCCCCC(=O)OCCOCCN(CC)CC",
        "output": "47"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.NCCCO.O=[N+]([O-])c1cccc([N+](=O)[O-])c1Cl>>O=[N+]([O-])c1cccc([N+](=O)[O-])c1NCCCO",
        "output": "304"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(CC)(c1ccc(O)c(C)c1)c1ccc(C#CC2(O)CCCCC2)c(C)c1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CCC(CC)(c1ccc(C#CC2(O)CCCCC2)c(C)c1)c1ccc(OS(=O)(=O)C(F)(F)F)c(C)c1",
        "output": "731"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CC[C@H](N)[C@H](C(F)(F)F)C1.O=Cc1ccc2c(c1)NC(=O)CS2.O=S(=O)([O-])[O-].[BH4-].[Na+].[Na+].[Na+]>>CC(C)(C)OC(=O)N1CC[C@H](NCc2ccc3c(c2)NC(=O)CS3)[C@H](C(F)(F)F)C1",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CNC(=O)c1ccc(Oc2ccc3c(c2)CCNCC3)nc1.O=CC1CC1>>CNC(=O)c1ccc(Oc2ccc3c(c2)CCN(CC2CC2)CC3)nc1",
        "output": "484"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC.ClCCl.O.O=S(=O)(O)O.O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].OCc1ccc(F)c(Br)c1.[Cl-].[K+].[K+]>>O=Cc1ccc(F)c(Br)c1",
        "output": "179"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)c1ccc(-c2nc3cc(-c4c(F)cncc4F)c(-c4cccnc4)nc3[nH]2)cc1.Cl.[Na+].[OH-]>>O=C(O)c1ccc(-c2nc3cc(-c4c(F)cncc4F)c(-c4cccnc4)nc3[nH]2)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cl.O.O=C(C1CC1)N1CCN2CC1Cc1ccc([N+](=O)[O-])cc12.O=C([O-])O.[Fe].[Na+]>>Nc1ccc2c(c1)N1CCN(C(=O)C3CC3)C(C2)C1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C(=O)O)c1ccc(-c2cn3ccccc3n2)cc1.CN(C)CCN.Cl.ClC(Cl)Cl.O=S(Cl)Cl.c1ccncc1>>CC(C(=O)NCCN(C)C)c1ccc(-c2cn3ccccc3n2)cc1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Cc1ccc(C(=O)O)cc1F.O=C([O-])O.O=S(=O)(O)O.[Na+]>>CCOC(=O)c1ccc(C)c(F)c1",
        "output": "33"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN.O=S(=O)(Cl)c1ccc(Br)c(F)c1>>CCNS(=O)(=O)c1ccc(Br)c(F)c1",
        "output": "43"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CCOc1cc2ncc(C#N)c(Nc3cccc(Br)c3)c2cc1[N+](=O)[O-].CO.O.[Cl-].[Fe].[NH4+]>>CCOc1cc2ncc(C#N)c(Nc3cccc(Br)c3)c2cc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCN(C2CCNCC2)C1.O=C1c2c(-c3ccccc3F)cc(Cl)nc2OCCCN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>O=C1c2c(-c3ccccc3F)cc(N3CCC(N4CCCC4)CC3)nc2OCCCN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccccc1.CCOCC.Cc1ccccc1CBr.Nc1c2c(nc3ccccc13)CCCC2=O.O.[K+].[OH-]>>Cc1ccccc1CNc1c2c(nc3ccccc13)CCCC2=O",
        "output": "272"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CCO.CCOc1cc(C=O)cc(OCC)c1N.Cl.Cl.[BH3-]C#N.[Na+].c1cc2nc(NC3CCNCC3)oc2cn1>>CCOc1cc(CN2CCC(Nc3nc4ccncc4o3)CC2)cc(OCC)c1N",
        "output": "567"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(N)=O.CCOC(C)=O.CN(C)C=O.NC1C(=O)N2C(C(=O)O)=C(CSc3nncs3)CS[C@H]12.O.O=CNc1nc(C(=NOCCOC=O)C(=O)O)cs1.O=P(Cl)(Cl)Cl>>O=CNc1nc(C(=NOCCOC=O)C(=O)NC2C(=O)N3C(C(=O)O)=C(CSc4nncs4)CS[C@H]23)cs1",
        "output": "587"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CC(C(=O)O)c2ccccc21.CC(C)=C(Cl)N(C)C.CCN(CC)CC.CN.CN(C)c1ccncc1.Cl.ClCCl>>CNC(=O)C1CN(C(=O)OC(C)(C)C)c2ccccc21",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#C[C@H]1CC[C@@H](C#N)N1C(=O)CCl.CC#N.NC1CCCC1>>CC#C[C@H]1CC[C@@H](C#N)N1C(=O)CNC1CCCC1",
        "output": "330"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.Nc1cc(Cl)nc(Cl)c1>>Nc1cc(Cl)nc(N2CCOCC2)c1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COCCOc1cc([N+](=O)[O-])cc(C(F)(F)F)c1.COc1cc(N)cc(OC2CCOC2)c1>>COCCOc1cc(N)cc(C(F)(F)F)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCOc1nc(N)c2nc(OC)n(CCCCCl)c2n1.CCN(C(C)C)C(C)C.CN(C)C=O.CN1CCNCC1>>CCCCOc1nc(N)c2nc(OC)n(CCCCN3CCN(C)CC3)c2n1",
        "output": "138"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1nccn1-c1ccc(Cl)cc1[N+](=O)[O-].CCO.ClC(Cl)Cl.Cl[Sn]Cl.O.O.[Na+].[OH-]>>CC(C)c1nccn1-c1ccc(Cl)cc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOCC.COC(=O)Cc1nc(-c2ccccc2)oc1C.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Mg+2].[Na+].[OH-]>>Cc1oc(-c2ccccc2)nc1CCO",
        "output": "343"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(SCCCCOc2cc3c(cc2C)NC(=O)OC3(C)C)cc1.OO>>Cc1ccc(S(=O)CCCCOc2cc3c(cc2C)NC(=O)OC3(C)C)cc1",
        "output": "199"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCC.CCN(CC)CC.CCOC(=O)C(=O)N(CCCCCCO)C(C)(C)C.CCOC(C)=O.CS(C)=O.ClCCl.O=C1CC[C@@H](C(=O)O)N1>>CCOC(=O)C(=O)N(CCCCCC=O)C(C)(C)C",
        "output": "142"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.C[C@H]1CN(C(=O)OC(C)(C)C)CCN1.ClCCl.O=[N+]([O-])c1ccc(F)c(Cl)c1>>C[C@H]1CN(C(=O)OC(C)(C)C)CCN1c1ccc([N+](=O)[O-])cc1Cl",
        "output": "26"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.O=Cc1ccc(OCc2ccccc2)cc1.[BH4-].[Na+]>>OCc1ccc(OCc2ccccc2)cc1",
        "output": "356"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COCC1(NC(=O)OCc2ccccc2)CCCC1.[Pd]>>COCC1(N)CCCC1",
        "output": "574"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCc1ccc(Br)cc1[N+](=O)[O-].COCCOC.O.O=C([O-])[O-].OB(O)c1ccc(Cl)cc1.[Na+].[Na+]>>CCc1ccc(-c2ccc(Cl)cc2)cc1[N+](=O)[O-]",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)N(C)C.CC(c1ccc(O)cc1Cl)C(O)(c1ccc2oc(=O)n(C)c2c1)C(F)(F)F.CCOC(=O)C(C)(C)Br.Cl.O.[Na+].[OH-]>>CCOC(=O)C(C)(C)Oc1ccc(C(C)C(O)(c2ccc3oc(=O)n(C)c3c2)C(F)(F)F)c(Cl)c1",
        "output": "305"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCc1nc(OC)c(NC(=O)N2CCN(c3cc(F)cc(F)c3)CC2)cc1C(=O)O.Nc1cc(CO)cc(Nc2c3ccccc3nc3ccccc23)c1>>CCc1nc(OC)c(NC(=O)N2CCN(c3cc(F)cc(F)c3)CC2)cc1C(=O)Nc1cc(CO)cc(Nc2c3ccccc3nc3ccccc23)c1",
        "output": "739"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCNc1cc(C(F)(F)F)c(C(=O)N(C(C)C)[C@@H]2CCCN(C(=O)OC(C)(C)C)C2)cc1[N+](=O)[O-].[C].[Pd]>>CCNc1cc(C(F)(F)F)c(C(=O)N(C(C)C)[C@@H]2CCCN(C(=O)OC(C)(C)C)C2)cc1N",
        "output": "489"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)C(F)(F)c1ccc(Cl)cc1OCC.CO.O.O.[Li+].[OH-]>>CCOc1cc(Cl)ccc1C(F)(F)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)n1nc(CCC=O)cc1-c1ccccc1.CCN(C(C)C)C(C)C.Cc1ccc(N2CCNCC2)c(C)c1.[Na+]>>Cc1ccc(N2CCN(CCCc3cc(-c4ccccc4)n(C(C)(C)C)n3)CC2)c(C)c1",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1nccc2c1[nH]c1ccc(-c3cc(Cl)cc(Cl)c3)cc12.ClC(Cl)Cl.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cc1c2[nH]c3ccc(-c4cc(Cl)cc(Cl)c4)cc3c2cc[n+]1[O-]",
        "output": "820"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1[nH]c2ccc(Br)cc2c1S(=O)(=O)N1CCCC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>O=S(=O)(c1c(CO)[nH]c2ccc(Br)cc12)N1CCCC1",
        "output": "711"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)N.COC(=O)c1ccc(OCc2c(-c3ccc(F)c(F)c3)noc2CO)nc1.C[Al](C)C>>CC(C)NC(=O)c1ccc(OCc2c(-c3ccc(F)c(F)c3)noc2CO)nc1",
        "output": "862"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(CC)c1cc(C(=O)OC)cc(OC)n1.Cl>>CCC(CC)c1cc(C(=O)O)cc(OC)n1",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCc1cn(Cc2ccc(OCCc3ccc(CC)cn3)cc2)nc1OCC.Cl.[Na+].[OH-]>>CCOc1nn(Cc2ccc(OCCc3ccc(CC)cn3)cc2)cc1CCC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CO.Cc1ccc([N+](=O)[O-])c(CC(=O)O)c1.ClCCl.ClCCl.F[P-](F)(F)(F)(F)F>>Cc1ccc([N+](=O)[O-])c(CC(=O)N2CCOCC2)c1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cl.N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(Cl)cc3)CN2)CC1.O=C(O)C1(N2CCCCC2)CC1>>N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(Cl)cc3)CN2C(=O)C2(N3CCCCC3)CC2)CC1",
        "output": "297"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1cc(CC(=O)OC(C)(C)C)ccc1NC(=O)Nc1ccccc1Cl.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(CC(=O)O)ccc1NC(=O)Nc1ccccc1Cl",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1ccc2cc(O)cc(CCNC(C)=O)c2c1.ClCCl.[Na+].[OH-]>>CC(=O)NCCc1cc(O)cc2ccc(O)cc12",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COCc1nc(Cl)cc(Cl)n1.NCCc1ccc(Cl)cc1Cl.O.O=C([O-])O.[Na+]>>COCc1nc(Cl)cc(NCCc2ccc(Cl)cc2Cl)n1",
        "output": "166"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1cnc(-c2ccncc2)nn1.CO.[Na+].[OH-]>>O=C(O)c1cnc(-c2ccncc2)nn1",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCI.O=C([O-])[O-].OC1(c2ccc(F)c(F)c2)CCNC1.[Na+].[Na+]>>CCN1CCC(O)(c2ccc(F)c(F)c2)C1",
        "output": "184"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.C[C@@H]1CC[C@H](NC(=O)C2(NC(=O)OC(C)(C)C)CCCCC2)[C@@H](O)CN1C(=O)OCc1ccccc1.[H][H].[Pd]>>C[C@@H]1CC[C@H](NC(=O)C2(NC(=O)OC(C)(C)C)CCCCC2)[C@@H](O)CN1",
        "output": "428"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.O.O.O=C([O-])c1cnc2cc(O)ccn12.[Li+].[OH-]>>O=C(O)c1cnc2cc(O)ccn12",
        "output": "151"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCc1nc2c(N)nc(C)c(C)c2n1CCCCN.CCOCC.ClCCl.O=C=Nc1ccccc1>>CCCCc1nc2c(N)nc(C)c(C)c2n1CCCCNC(=O)Nc1ccccc1",
        "output": "35"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1c(C(N)=O)[nH]c2c(Br)cc(F)cc12.Cc1ccc(B(O)O)cc1>>Cc1ccc(-c2cc(F)cc3c(C)c(C(N)=O)[nH]c23)cc1",
        "output": "833"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CCN(CC)CC.CO.ClCCl.N#Cc1ccc(-c2cncc3c2CCCC3N)cc1>>CC(=O)NC1CCCc2c(-c3ccc(C#N)cc3)cncc21",
        "output": "45"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.COc1ccccc1C(=O)CBr.O=C(Nc1cccc(O)c1)c1ccccn1.O=C([O-])[O-].[K+].[K+]>>COc1ccccc1C(=O)COc1cccc(NC(=O)c2ccccn2)c1",
        "output": "221"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Cc2ccccc2)(C(=O)O)CC1.CN(C)C(=O)Oc1cccc(N)c1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.c1ccncc1>>CN(C)C(=O)Oc1cccc(NC(=O)C2(Cc3ccccc3)CCN(C(=O)OC(C)(C)C)CC2)c1",
        "output": "365"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1cc(Cl)c(=O)n(CC(F)(F)F)c1.O.O.[Li+].[OH-]>>O=C(O)c1cc(Cl)c(=O)n(CC(F)(F)F)c1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)Oc1nc2cc(OC(C)(C)C)cc([C@H](O)CO)c2s1.CS(=O)(=O)Cl.c1ccncc1>>CC(C)Oc1nc2cc(OC(C)(C)C)cc([C@H](O)COS(C)(=O)=O)c2s1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(=O)CC1.ClCCl.N#CC1CCNCC1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+]>>CC(C)(C)OC(=O)N1CCC(N2CCC(C#N)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1CCNCC1.CN(C)C=O.N=C=N.O=C(O)/C=C/c1n[nH]c2ccccc12.O=C([O-])[O-].On1nnc2ccccc21>>CCOC(=O)C1CCN(C(=O)/C=C/c2n[nH]c3ccccc23)CC1",
        "output": "811"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)C1CCC(c2ncc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)s2)CC1.O=C(O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1>>O=C(Nc1ccc(-c2cnc(C3CCC(C(=O)O)CC3)s2)cc1)Nc1ccccc1F",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)[C@@H]1CCN(C(=O)c2cc3nccc(Cl)c3s2)C1.CNC(=O)c1c(C)n(C)c2cc(O)ccc12.O=C([O-])[O-].[Cs+].[Cs+]>>CNC(=O)c1c(C)n(C)c2cc(Oc3ccnc4cc(C(=O)N5CC[C@@H](N(C)C)C5)sc34)ccc12",
        "output": "936"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1ccc(OCc2c(-c3cccc(F)c3)noc2C)nc1.NC1CCOCC1>>Cc1onc(-c2cccc(F)c2)c1COc1ccc(C(=O)NC2CCOCC2)cn1",
        "output": "862"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO.CCN(CC)CC.CN(C)c1ccncc1.ClCCl>>CCCCCCCCCCCCCC=C[C@@H](O)[C@@H](N)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C",
        "output": "602"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CNC.O=C(Cl)c1cccc(Br)c1.O=C(c1ccc(Br)cc1)N1CCOCC1>>CN(C)C(=O)c1cccc(Br)c1",
        "output": "201"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCCN.CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.CO.Cl.Cl.ClC(Cl)Cl.O.O=C(N[C@@H](Cc1ccccc1)C(=O)O)OCc1ccccc1.O=C(O)CC(O)(CC(=O)O)C(=O)O.On1nnc2ccccc21>>CC(C)(C)OC(=O)NCCNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCC(C)=O.COC(=O)c1ccc(Br)nc1.Cc1ccccc1.O.[H-].[Na+].[OH-]>>OCc1ccc(Br)nc1",
        "output": "522"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(CCCCl)c1ccc(F)cc1.O=C([O-])[O-].[K+].[K+].c1cc2c3c(c1)[C@H]1CNCC[C@H]1N3CCC2>>O=C(CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CCC3)c1ccc(F)cc1",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)Cl.CCn1c(N)c(C#N)c2ccc([N+](=O)[O-])cc21.[H-].[Na+]>>CCn1c(NC(C)=O)c(C#N)c2ccc([N+](=O)[O-])cc21",
        "output": "332"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)N1CCC(COc2cc(F)c(C(=O)O)cc2C2CC2)CC1.CS(N)(=O)=O.NS(=O)(=O)C1CC1.O=C(O)c1cc(C2CC2)c(OCC2(F)CCN(Cc3cc(C(F)(F)F)cc(Cl)c3F)CC2)cc1F>>CS(=O)(=O)N1CCC(COc2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc2C2CC2)CC1",
        "output": "580"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2ccccc2)CN1.O=C(O)Cn1nccn1>>O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2ccccc2)CN1C(=O)Cn1nccn1",
        "output": "297"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.COc1cccc(CN(C)c2cncc(-c3cccc(O)c3)c2)c1.ClCCl>>CN(Cc1cccc(O)c1)c1cncc(-c2cccc(O)c2)c1",
        "output": "732"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCP(=O)(CCC)c1cccc(N)c1.CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Cl)n2)cc1)OCC.FC(F)(F)c1cnc(Cl)nc1Cl>>CCCP(=O)(CCC)c1cccc(Nc2ncc(C(F)(F)F)c(Cl)n2)c1",
        "output": "808"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CN(C)C=O.Cc1ccc2c(Cl)cccc2c1Br.[Li]CCCC>>Cc1ccc2c(Cl)cccc2c1C=O",
        "output": "638"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C1(C)CCNCC1.CN1CCCC1=O.Cc1c(Cl)nnc(Cc2ccccc2)c1C>>CCOC(=O)C1(C)CCN(c2nnc(Cc3ccccc3)c(C)c2C)CC1",
        "output": "406"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O=[N+]([O-])c1cccc(S(=O)(=O)Cl)c1.OCCNCCO>>O=[N+]([O-])c1cccc(S(=O)(=O)N(CCO)CCO)c1",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCNCCC.CCN(C(C)C)C(C)C.COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(Cl)nc2c1.CS(C)=O.O>>CCCN(CCC)c1nc2cc(C(=O)OC)ccc2nc1-c1ccc(F)cc1",
        "output": "505"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCO.O=C([O-])O.O=C(c1ccc([N+](=O)[O-])cc1Cl)N1Cc2ccnn2Cc2ccccc21.[Na+]>>Nc1ccc(C(=O)N2Cc3ccnn3Cc3ccccc32)c(Cl)c1",
        "output": "28"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.FC(F)(F)Oc1ccc(-n2cnc(-c3ccc(Br)cc3)n2)cc1.[C-]#N.[C-]#N.[Pd].[Zn+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1",
        "output": "65"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=O.CC#N.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(=O)CBr.CCOC(=O)CN(N)c1cccc(Cl)c1.CCOC(=O)Cn1c2c(c3ccc(Cl)cc31)CCN(C)C2.CCOC(=O)Cn1cc(CCNC)c2ccc(Cl)cc21.CCOC(CCCNC)OCC.CN1CCc2c(n(CC(=O)O)c3cc(Cl)ccc23)C1.CNCCC(C)C.Cl.NNc1cccc(Cl)c1.O=C(O)C(F)(F)F.[Na+].[OH-]>>CC(C)CCN(C)C(=O)Cn1c2c(c3ccc(Cl)cc31)CCN(C)C2",
        "output": "494"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCN(CC)c1cc(Cl)nc(C)n1.Cc1cc(C)c(N)c(C)c1>>CCCCN(CC)c1cc(Nc2c(C)cc(C)cc2C)nc(C)n1",
        "output": "161"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrC(Br)(Br)Br.CC(C)(C)OC(=O)N1CCC(CCO)CC1.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCC(CCBr)CC1",
        "output": "378"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cc1noc(C)c1-c1cc(-c2cccnc2C2CC2)c2[nH]c(=O)[nH]c2c1.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cc1noc(C)c1-c1cc(-c2ccc[n+]([O-])c2C2CC2)c2[nH]c(=O)[nH]c2c1",
        "output": "262"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)Cc1ccc(OC)cc1OCc1ccccc1.[C].[Pd]>>COC(=O)Cc1ccc(OC)cc1O",
        "output": "23"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(CCn2cnc(-c3cc4nccc(Cl)c4s3)c2)CC1.CC(C)(C)[O-].CN1CCCC1=O.Cl.Cl.Nc1ccc(O)c(F)c1.Nc1ccc(O)c(F)c1.[K+].[O-]c1ccccc1>>CC(C)(C)OC(=O)N1CCN(CCn2cnc(-c3cc4nccc(Oc5ccc(N)cc5F)c4s3)c2)CC1",
        "output": "936"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cc1cc([N+](=O)[O-])cc(C)c1-c1ccc(C(F)(F)F)cc1.[H][H].[Pd]>>Cc1cc(N)cc(C)c1-c1ccc(C(F)(F)F)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Nc1nc(N)c2c(N3CCNCC3)cccc2n1.O=C(Cl)c1ccccc1>>Nc1nc(N)c2c(N3CCN(C(=O)c4ccccc4)CC3)cccc2n1",
        "output": "201"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC(=O)c1cccc([N+](=O)[O-])c1.CC(C)O.CO.ClCCl.[BH3-]C#N.[NH4+].[Na+]>>CC(N)c1cccc([N+](=O)[O-])c1",
        "output": "552"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCBr.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].O=Cc1ccc(O)cc1.[K+].[K+]>>CCCOc1ccc(C=O)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NN(Cc1ccc(-c2nnn(C(C)(C)c3ccccc3)n2)cc1)C[C@H](O)[C@@H](N)Cc1ccccc1.CC[C@H](C)[C@H](NC(=O)OC)C(=O)O.CN(C)C=O.ClCCCl.On1nnc2ccccc21>>CC[C@H](C)[C@H](NC(=O)OC)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2nnn(C(C)(C)c3ccccc3)n2)cc1)NC(=O)OC(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC#CCOC(=O)Cl.Cc1nsnc1/C(=N\\OCc1cccc(N)n1)c1ccccc1.ClCCl.O.c1ccncc1>>CC#CCOC(=O)Nc1cccc(CON=C(c2ccccc2)c2nsnc2C)n1",
        "output": "502"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCNC(=O)Nc1cc(C#C[Si](C)(C)C)c(-c2cncc(-c3n[nH]c(=O)o3)c2)cn1.CO.Cl.ClCCl.[Na+].[OH-]>>C#Cc1cc(NC(=O)NCC)ncc1-c1cncc(-c2n[nH]c(=O)o2)c1",
        "output": "337"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)c1cc(Oc2nccs2)cc(-c2ccc(C)cc2C#N)c1.Cl.[Li+].[OH-]>>Cc1ccc(-c2cc(Oc3nccs3)cc(C(=O)O)c2)c(C#N)c1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.ClCCl.Cn1c(CO[Si](C)(C)C(C)(C)C)cc2cc3c(cc21)CCCCC3O.O=[Ru](=O)(=O)[O-]>>Cn1c(CO[Si](C)(C)C(C)(C)C)cc2cc3c(cc21)CCCCC3=O",
        "output": "32"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CO.Cc1c(-c2ccccn2)nc2c(F)cccc2c1Cl.Cl.Nc1cc(N2CCOCC2)ccc1N1CCOCC1>>Cc1c(-c2ccccn2)nc2c(F)cccc2c1Nc1cc(N2CCOCC2)ccc1N1CCOCC1",
        "output": "115"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCOC(=O)c1csc(Br)n1.O=C(NCC1CCCNC1)OCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1csc(N2CCCC(CNC(=O)OCc3ccccc3)C2)n1",
        "output": "657"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(c1ccncc1)c1ccc(N)cc1.CCN(CC)CC.COc1ccc(C(=O)Cl)cc1OC.ClCCl>>COc1ccc(C(=O)Nc2ccc(C(C)(C)c3ccncc3)cc2)cc1OC",
        "output": "11"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(C)=O.O=C([O-])[O-].O=S(c1ccc(C=Cc2nc(CCl)cs2)cc1)C(F)(F)F.Oc1ccc(CCCCn2ccnn2)cc1.[Cs+].[Cs+].[I-].[K+]>>O=S(c1ccc(/C=C/c2nc(COc3ccc(CCCCn4ccnn4)cc3)cs2)cc1)C(F)(F)F",
        "output": "785"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2C#N)cc1.CN(C)C=O.Cl.O.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1",
        "output": "390"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1c(-c2ccc(F)cc2)oc2ccc(O)c(F)c12.CO.Cl.O.[Na+].[OH-]>>O=C(O)c1c(-c2ccc(F)cc2)oc2ccc(O)c(F)c12",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COc1ccc(C2=NN(C3CCN(C(=O)[C@@H](C)NC(=O)OC(C)(C)C)CC3)C(=O)C(C)(C)C2)cc1OC.Cl>>COc1ccc(C2=NN(C3CCN(C(=O)[C@@H](C)N)CC3)C(=O)C(C)(C)C2)cc1OC",
        "output": "431"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)C1CCCc2c1ncn2C(c1ccccc1)(c1ccccc1)c1ccccc1.Cl.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OCC1CCCc2c1ncn2C(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "225"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.NN.O.O=[N+]([O-])c1ccc2c(c1)SCCN2CCCN1CCCC1.[Ni]>>Nc1ccc2c(c1)SCCN2CCCN1CCCC1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cc1cc(C)c(NC(=O)Nc2cc(-c3ccc([N+](=O)[O-])cc3)ccc2C(=O)N[C@H](C(=O)OC(C)(C)C)C2CCCCC2)c(C)c1.[Pd]>>Cc1cc(C)c(NC(=O)Nc2cc(-c3ccc(N)cc3)ccc2C(=O)N[C@H](C(=O)OC(C)(C)C)C2CCCCC2)c(C)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CSc1ccc(F)c(B2OC(C)(C)C(C)(C)O2)c1F.C[C@H]1O[C@@H](c2ccncc2NC(=O)c2ccc(F)c(Br)n2)C[C@@H](NC(=O)OC(C)(C)C)[C@]1(C)O>>CSc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](NC(=O)OC(C)(C)C)[C@](C)(O)[C@@H](C)O3)ccc2F)c1F",
        "output": "939"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC(=O)OCn1c(SCc2nccc3ccsc23)nc2ccccc21.CCOCC.ClC(Cl)Cl.O.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.O=S([O-])[O-].[Na+].[Na+].[Na+]>>CCCC(=O)OCn1c(S(=O)Cc2nccc3ccsc23)nc2ccccc21",
        "output": "595"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1cc(N)c([N+](=O)[O-])cn1.[Pd]>>COC(=O)c1cc(N)c(N)cn1",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(C(=O)Cl)cc1.CS(=O)(=O)c1ccc(Oc2ncnc3c2cnn3C2CCNCC2)cc1.O=C(O)C(F)(F)F>>COc1ccc(C(=O)N2CCC(n3ncc4c(Oc5ccc(S(C)(=O)=O)cc5)ncnc43)CC2)cc1",
        "output": "201"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)C1(Cl)C(C)(C)C1(Cl)Cl.O.O=CO.O=S(=O)(O)O>>CC1(C)C(Cl)(Cl)C1(Cl)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.COC(=O)c1cc(NCC2CCCC2)nc(Cl)n1.ClCCl.Nc1ccc(CO)cc1.O=C(O)c1cc(N(CC2CC2)C2CCCCC2)ncn1>>O=C(Nc1ccc(CO)cc1)c1cc(N(CC2CC2)C2CCCCC2)ncn1",
        "output": "548"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1ccc2c(c1)N(C)C(=O)CO2.Cl.O.O.[Li+].[OH-]>>CN1C(=O)COc2ccc(C(=O)O)cc21",
        "output": "222"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCC2=NCCCN2CC1.C1CCOC1.C[Si](C)(C)C#N.Cc1cc[n+]([O-])cc1>>Cc1ccnc(C#N)c1",
        "output": "720"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.CCOC(C)=O.COC(=O)Cc1ccc(OC)c([N+](=O)[O-])c1.ClCCl>>COC(=O)Cc1ccc(O)c([N+](=O)[O-])c1",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)-c3n[nH]c(O)c3CC4)cc2)CCC1.O=C(O)C(F)(F)F>>NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)-c3n[nH]c(O)c3CC4)cc2)CCC1",
        "output": "793"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)Oc1ccc(C[C@H](NC(=O)OCc2ccccc2)C(=O)O)cc1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCOCC1.COC(=O)[C@H](C)N.Cl.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>COC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)OCc1ccccc1",
        "output": "129"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)CC(C)C.Fc1ccc(C(CCCCl)c2ccc(F)cc2)cc1.O.O=C([O-])[O-].O=c1[nH]c2cc(I)ccc2n1C1CCNCC1.[I-].[K+].[Na+].[Na+]>>O=c1[nH]c2cc(I)ccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1",
        "output": "138"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=[N+]=[N-].CC(=O)O.O=C(O)c1ccccc1-c1ccc([N+](=O)[O-])cc1C(=O)OCc1ccccc1.O=C(OCc1ccccc1)c1cc([N+](=O)[O-])ccc1OS(=O)(=O)C(F)(F)F>>COC(=O)c1ccccc1-c1ccc([N+](=O)[O-])cc1C(=O)OCc1ccccc1",
        "output": "60"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)CNC(=O)/C=C/CCC#Cc1ccccc1.CO.[Pd]>>CC(C)CNC(=O)/C=C/CCCCc1ccccc1",
        "output": "717"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#Cc1ccc(C(=O)OC)c(Cl)c1.CCN(CC)CC.O=C(c1cccnc1Oc1cc(Cl)c(Br)cc1Cl)N1CCN(C2CC2)c2ccccc21.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1ccc(C#Cc2cc(Cl)c(Oc3ncccc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1Cl",
        "output": "659"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C#N)c1cccc(C(=O)Cl)c1.Nc1cccc(O)c1.O=C([O-])O.[Na+]>>CC(C)(C#N)c1cccc(C(=O)Nc2cccc(O)c2)c1",
        "output": "11"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(CCO)CC1.CC(C)(C)c1ccccc1O.CN(C)C=O.O.O=P([O-])([O-])[O-].[K+].[K+].[K+].c1ccncc1>>CC(C)(C)OC(=O)N1CCC(CCOc2ccccc2C(C)(C)C)CC1",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)[Mg]Cl.CN(C)C=O.Fc1ccc(OC2CCOC2)c(Br)c1>>O=Cc1cc(F)ccc1OC1CCOC1",
        "output": "638"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccccc1CC(=O)Cl.Nc1nc2ccc(C(F)(F)F)cc2s1>>COc1ccccc1CC(=O)Nc1nc2ccc(C(F)(F)F)cc2s1",
        "output": "553"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCC[C@@H]1Cc1c[nH]c2ccc(Br)cc12.COCCOC.Cc1ccc(S(=O)(=O)Cl)cc1.[K+].[OH-]>>Cc1ccc(S(=O)(=O)n2cc(C[C@H]3CCCN3C)c3cc(Br)ccc32)cc1",
        "output": "648"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CCN.CCOCC.COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccc(Cl)c([N+](=O)[O-])c1>>CCN(CC)CCNc1ccc(C2C(C(=O)OC)=C(C)NC(C)=C2C(=O)OC)cc1[N+](=O)[O-]",
        "output": "304"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1CCC(c2c[nH]c3ccc(O)cc23)CC1.O=S(=O)(Cl)c1ccc(Cl)cc1.[Na+].[OH-]>>CN1CCC(c2c[nH]c3ccc(OS(=O)(=O)c4ccc(Cl)cc4)cc23)CC1",
        "output": "380"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCc1cccc(=O)n1Cc1ccc(-c2ccccc2[N+](=O)[O-])cc1.CCO.[Ni]>>CCCCc1cccc(=O)n1Cc1ccc(-c2ccccc2N)cc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COCCN.O=Cc1cc(N2CCOCC2)nc(Cl)n1>>COCCNCc1cc(N2CCOCC2)nc(Cl)n1",
        "output": "775"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccc([N+](=O)[O-])cc1.O=Cc1cc(O)c(O)c([N+](=O)[O-])c1>>O=C(C=Cc1cc(O)c(O)c([N+](=O)[O-])c1)c1ccc([N+](=O)[O-])cc1",
        "output": "295"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)[C@@H](C)Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc4nccs4)c3)c12.NCCO>>C[C@@H](Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc4nccs4)c3)c12)C(=O)NCCO",
        "output": "392"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.Cl.O=C([C@@H]1Cc2ccccc2CN1C(=O)OCc1ccccc1)N1CCOCC1.O=C([O-])O.[Na+]>>O=C(OCc1ccccc1)N1Cc2ccccc2C[C@H]1CN1CCOCC1",
        "output": "490"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC1CCN(c2nc(C(F)(F)F)ccc2CNC(=O)Nc2ccncc2CO[Si](C)(C)C(C)(C)C)CC1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>CC1CCN(c2nc(C(F)(F)F)ccc2CNC(=O)Nc2ccncc2CO)CC1",
        "output": "708"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCOC(=O)C(C#N)=NOC(N(C)C)=[N+](C)C.CN(C)C=O.CN1CCOCC1.COCCCOc1ccccc1-n1c(Cl)c(C(=O)O)c2ccccc21.F[B-](F)(F)F>>COCCCOc1ccccc1-n1c(Cl)c(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c2ccccc21",
        "output": "256"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "O=C(O)c1ccc2c(c1)-c1nc(-c3ncnn3CC(F)(F)F)cn1CCO2.OCCN1CCNCC1>>O=C(c1ccc2c(c1)-c1nc(-c3ncnn3CC(F)(F)F)cn1CCO2)N1CCN(CCO)CC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClC(Cl)Cl.Nc1cccc(OCCCN2CCOCC2)c1.O.O=C(O)Cc1ccc(F)c(F)c1.On1nnc2ccccc21>>O=C(Cc1ccc(F)c(F)c1)Nc1cccc(OCCCN2CCOCC2)c1",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CC(=O)O.CC(C)(N)Cc1ccc(O)cc1.Cc1ccccc1.N#Cc1ccc(F)cc1.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(N)Cc1ccc(Oc2ccc(C#N)cc2)cc1",
        "output": "564"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.OCCCC12CC(c3ccccc31)c1ccccc12>>O=CCCC12CC(c3ccccc31)c1ccccc12",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)[O-].CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1ccc(S(=O)(=O)n2cc(CN3CCCC4(CCNCC4)C3=O)c3ccccc32)cc1.Cc1cccc(Cl)n1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1ccc(S(=O)(=O)n2cc(CN3CCCC4(CCN(c5cccc(C)n5)CC4)C3=O)c3ccccc32)cc1",
        "output": "220"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1cc(S(=O)(=O)Nc2cccc(-c3ccc(C(=O)O)cc3)c2)c(C)cc1Cl.F[B-](F)(F)F.N#CCN>>Cc1cc(S(=O)(=O)Nc2cccc(-c3ccc(C(=O)NCC#N)cc3)c2)c(C)cc1Cl",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1ccc(NC(=O)c2ccc(F)cc2C(F)(F)F)cc1.O=c1[nH]c2nccc(Cl)c2c2cc(C(F)(F)F)ccc12>>O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccc(C(F)(F)F)cc4c23)cc1)c1ccc(F)cc1C(F)(F)F",
        "output": "922"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](C)(C)O[C@@H](c1ccccc1-c1ccc(Cl)cc1)C1CCN(c2ccc(C(=O)O)cc2)CC1.CCN(CC)CC1CN(CC[C@H](CSc2ccccc2)Nc2ccc(S(N)(=O)=O)cc2S(=O)(=O)C(F)(F)F)CCO1>>CCN(CC)CC1CN(CC[C@H](CSc2ccccc2)Nc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCC([C@@H](O[Si](C)(C)C(C)(C)C)c5ccccc5-c5ccc(Cl)cc5)CC4)cc3)cc2S(=O)(=O)C(F)(F)F)CCO1",
        "output": "579"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CSCCN1.N#Cc1cn(Cc2ccc(F)cc2)c2cc(F)c(F)cc2c1=O>>N#Cc1cn(Cc2ccc(F)cc2)c2cc(N3CCSCC3)c(F)cc2c1=O",
        "output": "676"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[C@H](O)C(F)(F)F.N#Cc1cc(Cl)c(C2(O)CCC2)cn1>>C[C@H](Oc1cc(C#N)ncc1C1(O)CCC1)C(F)(F)F",
        "output": "651"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C[C@@](O)(CN)C1CC1.O=C(O)c1cc(Br)c(OCC(F)(F)F)nc1C(F)(F)F>>C[C@@](O)(CNC(=O)c1cc(Br)c(OCC(F)(F)F)nc1C(F)(F)F)C1CC1",
        "output": "674"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CCc1c(-c2ccccc2)c2c(c3c1[nH]c1ccc(OC)cc13)C(=O)NC2=O>>CCc1c(-c2ccccc2)c2c(c3c1[nH]c1ccc(O)cc13)C(=O)NC2=O",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl.FC(F)(F)c1ccc2c(c1)CC(CN1CCNCC1)O2.N#Cc1ccc(NC2CCC(OCC(=O)O)CC2)cc1C(F)(F)F.On1nnc2ccccc21>>N#Cc1ccc(NC2CCC(OCC(=O)N3CCN(CC4Cc5cc(C(F)(F)F)ccc5O4)CC3)CC2)cc1C(F)(F)F",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(-c2cc(Cl)ccc2N)ncn1.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COc1cc(-c2cc(Cl)ccc2NC(=O)C(F)(F)F)ncn1",
        "output": "106"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)C1=NN(c2cccc(C(=O)O)c2)C(=O)C1.CCOC(C)=O.CO.O=S(=O)(O)O>>COC(=O)c1cccc(N2N=C(C(C)C)CC2=O)c1",
        "output": "195"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.NC(=O)c1n[nH]cc1NCCc1cccc(N)c1.O=C=Nc1cc(C(F)(F)F)ccc1F>>NC(=O)c1n[nH]cc1NCCc1cccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)c1",
        "output": "473"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)C[C@@H]1NC[C@H](CC(C)C)NC1=O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F.O=C(O)[C@@H]1C[C@H]1c1ccccc1>>CC(C)C[C@H]1C(=O)N[C@@H](CC(C)C)CN1C(=O)[C@@H]1C[C@H]1c1ccccc1",
        "output": "297"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCCCCCCCCCCCNC.CCN(CC)CC.ClCCl.O=[N+]([O-])c1ccc(Cl)c(S(=O)(=O)Cl)c1>>CCCCCCCCCCCCCCCCCCN(C)S(=O)(=O)c1cc([N+](=O)[O-])ccc1Cl",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cl.F[P-](F)(F)(F)(F)F.NCc1cn(-c2ccc(-n3ccccc3=O)cc2)cn1.O=C(O)c1ccc(Cl)cc1>>O=C(NCc1cn(-c2ccc(-n3ccccc3=O)cc2)cn1)c1ccc(Cl)cc1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)Oc1ccccc1N.Cl.ClC(Cl)Cl.O.O=C([O-])[O-].S=C(Cl)Cl.[Na+].[Na+]>>CC(C)Oc1ccccc1N=C=S",
        "output": "114"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(NCCCCO)N1Cc2ccccc2C1.O=CCCCNC(=O)c1ccccc1>>O=CCCCNC(=O)N1Cc2ccccc2C1",
        "output": "142"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)CCCOc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(OC)cc4)cc3)c2cc1C#N.[Na+].[OH-]>>COc1ccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OCCCC(=O)O)c(C#N)cc34)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)C(F)(F)Cc1c[nH]c([N+](=O)[O-])n1.NCC(F)(F)C(N)=O>>NC(=O)C(F)(F)CNC(=O)C(F)(F)Cc1c[nH]c([N+](=O)[O-])n1",
        "output": "392"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CN1CCNCC1.Cc1cccc(-c2nc3ccccn3c2-c2ccnc(S(C)(=O)=O)n2)n1>>Cc1cccc(-c2nc3ccccn3c2-c2ccnc(N3CCN(C)CC3)n2)n1",
        "output": "679"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CN.O=C(O)c1ccc(C(F)(F)F)nc1>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1ccc(C(F)(F)F)nc1",
        "output": "674"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCOCC.CS(C)=O.O=C([O-])[O-].O=[N+]([O-])c1c(F)cccc1F.[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(c2cccc(F)c2[N+](=O)[O-])CC1",
        "output": "26"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C=Cc1ccc(C)cc1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>CCOC(=O)C=Cc1ccc(CBr)cc1",
        "output": "29"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Br.CC(=O)O.Cc1onc(CNC(=O)OCc2ccccc2)c1-c1ccc2nc[nH]c2c1>>Cc1onc(CN)c1-c1ccc2nc[nH]c2c1",
        "output": "574"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CCN1CCOCC1.COC(=O)[C@@H](N)CO.Cl.O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)OCc1ccccc1.On1nnc2ccccc21>>COC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1",
        "output": "129"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=C(C)n1c(=O)n(CC(=O)c2ccccc2F)c2ccccc21.CCO.Cl.NO.c1ccncc1>>C=C(C)n1c(=O)n(CC(=NO)c2ccccc2F)c2ccccc21",
        "output": "212"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(-c2cccc(C(=O)CC(=O)Nc3cc(C(F)(F)F)ccc3NC(=O)OC(C)(C)C)c2)cn1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(-c2cccc(C3=Nc4ccc(C(F)(F)F)cc4NC(=O)C3)c2)cn1",
        "output": "930"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1.O=C(Cl)CCl.O=C([O-])O.[Na+]>>O=C(CCl)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1",
        "output": "9"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.ClCCl.Fc1cc2nc(COc3ccccc3)n(Cc3ccc(OC(F)(F)F)cc3)c2cc1N1CCNCC1>>CC(=O)N1CCN(c2cc3c(cc2F)nc(COc2ccccc2)n3Cc2ccc(OC(F)(F)F)cc2)CC1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCC(O)(C=Cc1ccc(C(CC)(CC)c2ccc(OCC(=O)CCC(=O)OC)c(C)c2)cc1C)CC.CO.[K+].[OH-]>>CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(OCC(=O)CCC(=O)O)c(C)c2)cc1C)CC",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.COc1ccc(C(=O)O)cc1.Cl.ClCCl.OCCCBr>>COc1ccc(C(=O)OCCCBr)cc1",
        "output": "33"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.NCc1ccncc1.O.O=C(O)c1cc2ccnc(N(Cc3ccccc3)Cc3ccccc3)c2[nH]1.On1nnc2ccccc21>>O=C(NCc1ccncc1)c1cc2ccnc(N(Cc3ccccc3)Cc3ccccc3)c2[nH]1",
        "output": "137"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.N#Cc1cc(F)ccc1-c1c(F)ccc(Br)c1F>>CC1(C)OB(c2ccc(F)c(-c3ccc(F)cc3C#N)c2F)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(C(C)=O)cc(-c3ccsc3)c2)c1CCC(=O)OCC.[Na+].[OH-]>>CC(=O)c1cc(OCCCCCCc2cccc(OCCCC(=O)O)c2CCC(=O)O)cc(-c2ccsc2)c1",
        "output": "255"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1n[nH]c2c1C[C@@H]1C(c3ccncc3)[C@H]21.O.[Li+].[OH-]>>O=C(O)c1n[nH]c2c1C[C@@H]1C(c3ccncc3)[C@H]21",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CI.COCCOC.Cc1cc(C(=O)c2ccccc2)c(C)n1C(C)CO.[H-].[Na+]>>COCC(C)n1c(C)cc(C(=O)c2ccccc2)c1C",
        "output": "140"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.COc1ccc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c(N)c1.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COc1ccc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c(NC(=O)C(F)(F)F)c1",
        "output": "106"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(CO)CC1.CC(C)OC(=O)N=NC(=O)OC(C)C.Oc1c(Cl)cc(OCc2ccccc2)cc1Cl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCC(COc2c(Cl)cc(OCc3ccccc3)cc2Cl)CC1",
        "output": "550"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)c1cc(-c2ccc(OCc3ccccc3)cc2OCc2ccccc2)n[nH]1.CO.[K+].[OH-]>>O=C(O)c1cc(-c2ccc(OCc3ccccc3)cc2OCc2ccccc2)n[nH]1",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC#N.CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.ClCCl.O=C(O)CC1Cc2ccccc2C1.O=[Ru](=O)(=O)[O-].OCCC1Cc2ccccc2C1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>O=CCC1Cc2ccccc2C1",
        "output": "142"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.N#Cc1cccc(N=C=O)c1.Nc1ccc(S(=O)(=O)NCc2ccccc2)cc1>>N#Cc1cccc(NC(=O)Nc2ccc(S(=O)(=O)NCc3ccccc3)cc2)c1",
        "output": "473"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Clc1ccc2c(c1)CCNC2.O=C(O)c1cc([N+](=O)[O-])ccc1N1CCOCC1>>O=C(c1cc([N+](=O)[O-])ccc1N1CCOCC1)N1CCc2cc(Cl)ccc2C1",
        "output": "794"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(CN1CCOCC1)c1cc(NC(=O)Oc2ccccc2)no1.CCN(C(C)C)C(C)C.COc1cc2ncnc(Oc3cccc(N)c3)c2cc1OC>>COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)CN5CCOCC5)on4)c3)c2cc1OC",
        "output": "948"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=C(C)C(=O)Cl.CCN(CC)CC.ClC(Cl)Cl.Nc1ccc([N+](=O)[O-])cc1>>C=C(C)C(=O)Nc1ccc([N+](=O)[O-])cc1",
        "output": "10"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.COc1ccc2c(Cl)nc(Nc3cc[nH]n3)cc2c1>>COc1ccc2c(OC(C)C)nc(Nc3cc[nH]n3)cc2c1",
        "output": "433"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCOC(=O)c1nn(-c2cccc(Br)c2)c2c1CNCC2.CS(=O)(=O)Cl.ClCCl>>CCOC(=O)c1nn(-c2cccc(Br)c2)c2c1CN(S(C)(=O)=O)CC2",
        "output": "584"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COc1cc2ncc(C#N)c(Cl)c2cc1[N+](=O)[O-].Nc1ccc(Cl)cc1F>>COc1cc2ncc(C#N)c(Nc3ccc(Cl)cc3F)c2cc1[N+](=O)[O-]",
        "output": "115"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC1([C@H]2CCC3C4CC=C5C[C@@H](O)CC[C@]5(C)C4[C@@H](O)C[C@@]32C)OCCO1.CI.[H-].[Na+]>>CO[C@H]1CC[C@@]2(C)C(=CCC3C4CC[C@H](C5(C)OCCO5)[C@@]4(C)C[C@H](O)C32)C1",
        "output": "140"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(=O)CC1.ClCCCl.N[C@H]1C[C@@H]1c1ccccc1.[Na+]>>CC(C)(C)OC(=O)N1CCC(N[C@H]2C[C@@H]2c2ccccc2)CC1",
        "output": "236"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCl.O.O=C(Cl)N1CCOCC1.O=Cc1cccc(F)c1O.c1ccncc1>>O=Cc1cccc(F)c1OC(=O)N1CCOCC1",
        "output": "425"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.CC(C)Cc1ccc(B(O)O)cc1.O=[N+]([O-])O>>CC(C)Cc1ccc(B(O)O)c([N+](=O)[O-])c1",
        "output": "21"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccccc4)oc4ccc(OC(F)(F)F)cc4c3=O)cc2)CCC1.NC1(c2ccc(-c3c(-c4ccccc4)oc4ccc(F)cc4c3=O)cc2)CCC1>>NC1(c2ccc(-c3c(-c4ccccc4)oc4ccc(OC(F)(F)F)cc4c3=O)cc2)CCC1",
        "output": "793"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(CN1CCN(Cc2ccccc2)CC1)c1ccccc1F.CO.O=C[O-].[NH4+].[OH-].[OH-].[Pd+2]>>CC(CN1CCNCC1)c1ccccc1F",
        "output": "84"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN.O=CCCCn1nnc2c(N3CCOCC3)nc(-c3cccc(O)c3)nc21.[BH3-]C#N.[Cl-].[Cl-].[Na+].[Zn+2]>>CNCCCCn1nnc2c(N3CCOCC3)nc(-c3cccc(O)c3)nc21",
        "output": "426"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.Nc1ccc(Cl)cc1C(=O)c1ccccc1.O.S=C(Cl)Cl>>O=C(c1ccccc1)c1cc(Cl)ccc1N=C=S",
        "output": "114"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "B.C1CCOC1.C1CCOC1.CO.O=C(NCCc1ccc(F)cc1)c1cccc(CSCCc2ccccc2)c1.O=C(O)C(F)(F)F>>Fc1ccc(CCNCc2cccc(CSCCc3ccccc3)c2)cc1",
        "output": "215"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cc(O)cc(C)c1C[C@H](N)C(=O)O>>Cc1cc(O)cc(C)c1C[C@H](NC(=O)OC(C)(C)C)C(=O)O",
        "output": "626"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)c1cc(C(=O)Nc2ccccc2N)cc(C(C)(C)C)c1O.Cl.FB(F)F.[BH4-].[Na+]>>CC(C)(C)c1cc(CNc2ccccc2N)cc(C(C)(C)C)c1O",
        "output": "215"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.Cc1ccc(S(=O)(=O)N2C=CNC(=O)C2CC(=O)NCCc2ccc(CCl)cc2)cc1.ClCCl>>Cc1ccc(S(=O)(=O)N2C=CNC(=O)C2CC(=O)NCCc2ccc(CN3CCCCC3)cc2)cc1",
        "output": "156"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1c(F)cccc1C(=O)O.C[C@H]1CC[C@@H](CNc2ccc(C(F)(F)F)cn2)NC1.ClCCl.F[B-](F)(F)F.O=C([O-])O.[Na+]>>COc1c(F)cccc1C(=O)N1C[C@@H](C)CC[C@H]1CNc1ccc(C(F)(F)F)cn1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CC2CNCC1O2.CCN(CC)CC.CS(=O)(=O)Cc1cc(Cl)nc(Cl)n1.Cl.ClCCl>>CS(=O)(=O)Cc1cc(N2CC3CCC(C2)O3)nc(Cl)n1",
        "output": "162"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC[SiH](CC)CC.COCCCOc1cc(C(O)[C@@H](C/C=C/C[C@H](C(=O)N(C)C)C(C)C)C(C)C)ccc1OC.ClCCCl.O=C(O)C(F)(F)F>>COCCCOc1cc(C[C@@H](C/C=C/C[C@H](C(=O)N(C)C)C(C)C)C(C)C)ccc1OC",
        "output": "447"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.COc1cc(O)ccc1C=O.Cc1ccccc1.OCc1ccc(Cl)c(Cl)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc(OCc2ccc(Cl)c(Cl)c2)ccc1C=O",
        "output": "347"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CC2(CCO1)CO2.CCOC(C)=O.Cc1ccc(S(=O)(=O)O)cc1.O.O=C([O-])[O-].[Na+].[Na+].c1cc(O[C@@H]2CCOC2)c2c(OCC3CCNCC3)noc2c1>>OC1(CN2CCC(COc3noc4cccc(O[C@@H]5CCOC5)c34)CC2)CCOCC1",
        "output": "76"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.OC(c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl)C1CC1.c1ccncc1>>CC(=O)OC(c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl)C1CC1",
        "output": "254"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.COc1ccc(N2CCC(N(C)C(=O)n3cnc(-c4ccc(OS(N)(=O)=O)cc4)c3)CC2)cc1.ClCCl>>CN(C(=O)n1cnc(-c2ccc(OS(N)(=O)=O)cc2)c1)C1CCN(c2ccc(O)cc2)CC1",
        "output": "402"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C[C@H]1CNCCN1C.Cc1c(-c2cnn(-c3ccc(C(=O)O)cn3)c2O)ccc(C#N)c1F>>Cc1c(-c2cnn(-c3ccc(C(=O)N4CCN(C)[C@@H](C)C4)cn3)c2O)ccc(C#N)c1F",
        "output": "256"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1cc(C(F)(F)F)c(Cl)cc1NC(=O)CC(=O)c1cccc(-c2ccccn2)c1.ClCCl.O=C(O)C(F)(F)F>>O=C1CC(c2cccc(-c3ccccn3)c2)=Nc2cc(C(F)(F)F)c(Cl)cc2N1",
        "output": "930"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)CCN(C)c1nc2ccc(N)cc2s1.O=C(O)c1ccc(-c2cccs2)cc1>>CN(C)CCN(C)c1nc2ccc(NC(=O)c3ccc(-c4cccs4)cc3)cc2s1",
        "output": "50"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(-c2nc3ccc(OC)cc3s2)cc1.Cl.Cl.c1ccncc1>>Oc1ccc(-c2nc3ccc(O)cc3s2)cc1",
        "output": "20"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.OC(c1ccc(OCc2ccc(Cl)cc2)c(F)c1)c1c[nH]c2ncccc12>>O=C(c1ccc(OCc2ccc(Cl)cc2)c(F)c1)c1c[nH]c2ncccc12",
        "output": "852"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)c1ccc(C=O)cc1.CO.Cl.NCCc1ccc(Cl)cc1.[BH4-].[Na+]>>CC(C)(C)c1ccc(CNCCc2ccc(Cl)cc2)cc1",
        "output": "468"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)OCCC(O)(CCN=[N+]=[N-])c1ccccc1.CCOC(C)=O.[Pd]>>CC(C)(C)[Si](C)(C)OCCC(O)(CCN)c1ccccc1",
        "output": "89"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])nc2)C(=O)C1.CO.[Pd]>>CC(C)(C)OC(=O)N1CCN(c2ccc(N)nc2)C(=O)C1",
        "output": "457"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.ClCCCl.N#Cc1ccc(Cn2cncc2CCN)cc1.O=C(O)C1CCCN(CC(c2ccccc2)c2ccccc2)C1.On1nnc2ccccc21>>N#Cc1ccc(Cn2cncc2CCNC(=O)C2CCCN(CC(c3ccccc3)c3ccccc3)C2)cc1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)N.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.O=C(O)c1ccc(O)cn1.On1nnc2ccccc21>>CC(C)(C)NC(=O)c1ccc(O)cn1",
        "output": "137"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCI.CS(C)=O.O=C([O-])[O-].Oc1ccccc1.[K+].[K+]>>CCOc1ccccc1",
        "output": "198"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F.O.O.O.[Li]O>>O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)C1=C/C(=C/N[C@@H]2CCCC[C@H]2N/C=C2\\C=C(C(C)(C)C)C=C(C(C)(C)C)C2=O)C(=O)C(C(C)(C)C)=C1.C[Si](C)(C)O[C@H]1COC[C@@H]1N=[N+]=[N-].[Co].[Pd]>>C[Si](C)(C)O[C@H]1COC[C@@H]1N",
        "output": "89"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O.OCc1nc2cncnc2[nH]1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCc1nc2cncnc2[nH]1",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(Cl)c(C)c(NCCOCCNC(=O)OC(C)(C)C)c2[N+](=O)[O-])cc1.ClCCl.Cl[Ni]Cl.O.[BH4-].[Na+]>>COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(Cl)c(C)c(NCCOCCNC(=O)OC(C)(C)C)c2N)cc1",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CCN1CCNCC1.CN(C)C=O.Nc1cc(Cl)ccc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>CCN(CC)CCN1CCN(c2ccc([N+](=O)[O-])c(N)c2)CC1",
        "output": "105"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=C(CC)C(=O)c1ccc(OCC(=O)SCC(C)C(=O)N(CC(=O)OC(C)(C)C)C2CCCC2)c(Cl)c1Cl.ClCCl.O=C(O)C(F)(F)F>>C=C(CC)C(=O)c1ccc(OCC(=O)SCC(C)C(=O)N(CC(=O)O)C2CCCC2)c(Cl)c1Cl",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(COCc1ccccc1)CO[Si](C)(C)C(C)(C)C.OCC(O)CO.[Pd]>>COC(CO)CO[Si](C)(C)C(C)(C)C",
        "output": "178"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.CCN(CC)C(=O)c1ccc(C(O)c2ccccc2OC)cc1.CO.c1ccncc1>>CCN(CC)C(=O)c1ccc(C(OC(C)=O)c2ccccc2OC)cc1",
        "output": "254"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)n1cc(CO)c2ccccc21.CCN(CC)CC.Cc1ccnc(N)c1C.O=C([O-])O.O=C1CCC(=O)O1.[Na+]>>CC(C)(C)OC(=O)n1cc(COC(=O)CCC(=O)O)c2ccccc21",
        "output": "139"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.CN1Cc2cc(C(C)(C)C)ccc2C(=O)N1c1cccc(Cl)c1CO.ClCCl.c1ccncc1>>CC(=O)OCc1c(Cl)cccc1N1C(=O)c2ccc(C(C)(C)C)cc2CN1C",
        "output": "254"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COc1ccc(C(=O)Cl)cc1.Cl.Cl.ClCCl.NCCCSc1ccncc1>>COc1ccc(C(=O)NCCCSc2ccncc2)cc1",
        "output": "271"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C(=O)O)CC1.CC(C)N1CCNCC1.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F>>CC(C)N1CCN(C(=O)[C@@H]2CC[C@@H](NC(=O)OC(C)(C)C)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Nc1cc(-c2cccc(CN3CCOCC3)c2)ccc1[N+](=O)[O-].[Pd]>>Nc1ccc(-c2cccc(CN3CCOCC3)c2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)n1ccc2ccc(-c3ccc(F)cc3)cc21.CCOCC.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)n1cc(Br)c2ccc(-c3ccc(F)cc3)cc21",
        "output": "796"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN(C)C=O.Nc1c[nH]c2ncc(Br)c(F)c12.O=C(O)c1cccnc1.O=C([O-])[O-].O=C1OCCN1P(=O)(Cl)N1CCOC1=O.[Li+].[Na+].[Na+].[OH-]>>O=C(Nc1c[nH]c2ncc(Br)c(F)c12)c1cccnc1",
        "output": "863"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)c1c(CO)c(-c2ccccc2)c2c3ccccc3ccn12.CCOCC.[Mn+4].[O-2].[O-2]>>CC(C)c1c(C=O)c(-c2ccccc2)c2c3ccccc3ccn12",
        "output": "520"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrBr.CC(=O)CC(=O)Nc1ccccc1F.CC(=O)O>>O=C(CBr)CC(=O)Nc1ccccc1F",
        "output": "173"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CC(C)(CO)c1ccc([N+](=O)[O-])cc1.ClCCl.c1c[nH]cn1>>CC(C)(CO[Si](C)(C)C(C)(C)C)c1ccc([N+](=O)[O-])cc1",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-c2ccc(F)c(F)c2)cc1[N+](=O)[O-].O.[Li+].[OH-]>>O=C(O)c1ccc(-c2ccc(F)c(F)c2)cc1[N+](=O)[O-]",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C(=O)CCl.COc1cccc(-c2cccn3nc(Nc4ccc(C5CCNCC5)cc4)nc23)c1F>>COc1cccc(-c2cccn3nc(Nc4ccc(C5CCN(CC(=O)N(C)C)CC5)cc4)nc23)c1F",
        "output": "340"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.O=C1CCCC(C(=O)NC2CCCCC2)C1.[Cl-].[NH4+]>>O=C(NC1CCCCC1)C1CCCC(O)C1",
        "output": "91"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)N1C(=O)C(CC(=O)OC(C)(C)C)(C(=O)OCC)c2cc(Cl)ccc21.ClCCl>>CCOC(=O)N1C(=O)C(CC(=O)O)(C(=O)OCC)c2cc(Cl)ccc21",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CC2(CN1)COC2.N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1F>>N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1N1CCC2(COC2)C1",
        "output": "26"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C#N)c1cc2ccccc2[nH]1.CO.N.[Rh]>>CC(C)(CN)c1cc2ccccc2[nH]1",
        "output": "246"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "OC1CCOCC1.Oc1ccc(Br)c(F)c1>>Fc1cc(OC2CCOCC2)ccc1Br",
        "output": "550"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.COCCNc1c([N+](=O)[O-])ccc(F)c1-c1ccccn1.[Pd]>>COCCNc1c(N)ccc(F)c1-c1ccccn1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COc1ccc(Cl)c(CC#N)c1.Cl>>COc1ccc(Cl)c(CCN)c1",
        "output": "246"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C(O)[C@@H]3CC[C@H](C(=O)O)CC3)s2)c1.ClCCCl.O.On1nnc2ccccc21.[Cl-].[NH4+]>>Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C(O)[C@@H]3CC[C@H](C(N)=O)CC3)s2)c1",
        "output": "313"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1ccc(Br)cc1C.ClCCl.O=C1CCC(=O)N1Br.[W]>>COC(=O)c1ccc(Br)cc1CBr",
        "output": "545"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COC(=O)[C@H](CN)NC(=O)c1sc(C(=O)NCc2cccc3[nH]ncc23)cc1Cl.F[P-](F)(F)(F)(F)F.O=C(O)C(F)(F)F.O=C(O)c1cccs1.On1nnc2ccccc21>>COC(=O)[C@H](CNC(=O)c1cccs1)NC(=O)c1sc(C(=O)NCc2cccc3[nH]ncc23)cc1Cl",
        "output": "736"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cl.NO.O=Cc1ccc(-c2ccc(O)cc2)c(Cl)c1Cl>>ON=Cc1ccc(-c2ccc(O)cc2)c(Cl)c1Cl",
        "output": "30"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)O.CC(C)=O.CCOC(=O)Cl.O.O=C(O)CCC1CCNCC1.O=C=O.[Na+].[OH-]>>CCOC(=O)N1CCC(CCC(=O)O)CC1",
        "output": "219"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)COc1ccn2nc(-c3ccccc3)c(-c3ccc(=O)n(C(C)C)n3)c2c1.[Na+].[OH-]>>CC(C)n1nc(-c2c(-c3ccccc3)nn3ccc(OCC(=O)O)cc23)ccc1=O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)CC(=O)c2c(C(F)(F)F)nn(-c3ccc(C#N)c(N[C@@H]4CC[C@@H](OC5CCCCO5)CC4)c3)c2C1.CCO.CS(C)=O.O.OO.[Cl-].[Na+].[Na+].[OH-]>>CC1(C)CC(=O)c2c(C(F)(F)F)nn(-c3ccc(C(N)=O)c(N[C@@H]4CC[C@@H](OC5CCCCO5)CC4)c3)c2C1",
        "output": "180"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)N1CC(CCl)C1.CN(C)C=O.Cl.N#CC1(c2ccc(O)cc2)CCOCC1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CC(C)N1CC(COc2ccc(C3(C#N)CCOCC3)cc2)C1",
        "output": "74"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CCN(C(C)C)C(C)C.Cc1ccc(Cn2c(CO)cc3cc(-c4ccc(OC(F)(F)F)cc4)ccc32)cc1.ClCCl>>CC(=O)OCc1cc2cc(-c3ccc(OC(F)(F)F)cc3)ccc2n1Cc1ccc(C)cc1",
        "output": "126"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(=O)c1ccncc1.CO.Cl.NO.O.[Na+].[OH-]>>CCC(=NO)c1ccncc1",
        "output": "212"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cn1c(C(F)(F)F)ccc(-c2ccc(Cl)cc2F)c1=O.O=S(=O)(O)O.O=[N+]([O-])O>>Cn1c(C(F)(F)F)ccc(-c2cc([N+](=O)[O-])c(Cl)cc2F)c1=O",
        "output": "21"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1.O.c1ccncc1>>COc1ccccc1OCC(CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1)OC(C)=O",
        "output": "254"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=O.CC(C)=O.CN(C)C=O.CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CO)CS[C@H]12)c1csc(NC(=O)C(F)(F)F)n1.O.O=S(=O)(O)O.O=S(=O)(O)O.O=[Cr](=O)=O.[Cr+6].[O-2].[O-2].[O-2]>>CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(C=O)CS[C@H]12)c1csc(NC(=O)C(F)(F)F)n1",
        "output": "183"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOc1cccc(CC(=O)OC)c1.Cl.[Na+].[OH-]>>CCOc1cccc(CC(=O)O)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCCC1=O.Clc1nccnc1C1CCCC1.O=C([O-])[O-].O=C(c1ccc(O)cc1)c1nc2ccccc2[nH]1.[Cs+].[Cs+]>>O=C(c1ccc(Oc2nccnc2C2CCCC2)cc1)c1nc2ccccc2[nH]1",
        "output": "210"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)(C)c1ccc(B(O)O)cc1.CCOC(=O)c1ccc2c(c1)C(C)(C)CC(c1cccc(Br)c1)N2.CCOC(C)=O.Cl[Pd]Cl.O=C([O-])[O-].[Na+].[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1ccc2c(c1)C(C)(C)CC(c1cccc(-c3ccc(C(C)(C)C)cc3)c1)N2",
        "output": "908"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCCCCBr.CC1(C)CC(=O)Nc2cc(O)ccc21.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CC1(C)CC(=O)Nc2cc(OCCCCBr)ccc21",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(C)COc1ccc(S(C)(=O)=O)cc1C(=O)O.CCOC(C)=O.Cc1nc2cc(N3CCNCC3)ccc2s1.Cl>>Cc1nc2cc(N3CCN(C(=O)c4cc(S(C)(=O)=O)ccc4OCC(C)C)CC3)ccc2s1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCOCC.CNC.O=S(=O)(Cl)CCCCCCCl>>CN(C)S(=O)(=O)CCCCCCCl",
        "output": "584"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCC[C@H](NC(=O)OC(C)(C)C)[C@H](O)C(=O)O.CCN=C=NCCCN(C)C.CC[C@H](N)c1ccccc1.Cl.ClCCl.O.On1nnc2ccccc21>>CCCC[C@H](NC(=O)OC(C)(C)C)[C@H](O)C(=O)N[C@@H](CC)c1ccccc1",
        "output": "599"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#Cc1cccnc1.Cc1ccccc1.Cc1ccncc1C(=O)Nc1cnc(-c2cc(I)ccc2C)cn1.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Cc1ccncc1C(=O)Nc1cnc(-c2cc(C#Cc3cccnc3)ccc2C)cn1",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.COc1ccc2c(c1)C(N)CC2.Cl.ClCCCl.O=C(O)C1COCCN1c1nc(Cl)ncc1Br.On1nnc2ccccc21>>COc1ccc2c(c1)C(NC(=O)C1COCCN1c1nc(Cl)ncc1Br)CC2",
        "output": "797"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)Cl.Cc1cc(CCCO)c2oc(Nc3ccc(Br)cc3)nc2c1.c1ccncc1>>Cc1cc(CCCOS(C)(=O)=O)c2oc(Nc3ccc(Br)cc3)nc2c1",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOC(=O)CCN.Cl.ClCCl.O=Cc1ccc(OCc2ccccc2)cc1.O=S(=O)([O-])[O-].[Mg+2]>>CCOC(=O)CCN=Cc1ccc(OCc2ccccc2)cc1",
        "output": "52"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.ClCCCl.c1cc(Nc2ccc3c(c2)CCCC3)c2c3c([nH]c2n1)CCNC3>>CC(=O)N1CCc2[nH]c3nccc(Nc4ccc5c(c4)CCCC5)c3c2C1",
        "output": "369"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)OC(=O)Cl.CCN(CC)CC.CCOCC.CN(C)C=O.CN1CCOCC1.CNC.Cl.NC(=O)c1ncn2c(=O)n(CC(=O)O)nnc12>>CN(C)C(=O)Cn1nnc2c(C(N)=O)ncn2c1=O",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.Nc1cccc(F)c1[N+](=O)[O-].O=C1CCC(=O)N1Br>>Nc1ccc(Br)c(F)c1[N+](=O)[O-]",
        "output": "4"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1ccc2[nH]ccc2c1.CN(C)C=O.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>O=Cc1c[nH]c2ccc(Br)cc12",
        "output": "266"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N[C@@H]1CCCCNC1=O.CI>>CN1CCCC[C@@H](NC(=O)OC(C)(C)C)C1=O",
        "output": "83"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1ccccc1N1CCNCC1.Fc1ccc(NCCCCl)cc1.O.O=C([O-])[O-].[Na+].[Na+]>>COc1ccccc1N1CCN(CCCNc2ccc(F)cc2)CC1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)[Si](OCCCCBr)(C(C)C)C(C)C.CN(C)C=O.O=C([O-])O.O=C1COc2ccc(CO)cc2N1.[H-].[Na+].[Na+]>>CC(C)[Si](OCCCCN1C(=O)COc2ccc(CO)cc21)(C(C)C)C(C)C",
        "output": "367"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1CCCn2c1cc(Cl)nc2=O.OCc1ccc(F)cc1>>CN1CCCn2c1cc(OCc1ccc(F)cc1)nc2=O",
        "output": "653"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC[C@H](C)Nc1cc(C(=O)OC)cc(S(C)(=O)=O)n1.Cl.[Li+].[OH-]>>CC[C@H](C)Nc1cc(C(=O)O)cc(S(C)(=O)=O)n1",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)CC1CNC(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.N#Cc1ccc(C(=O)O)cc1>>CC(C)(C)CC1CN(C(=O)c2ccc(C#N)cc2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F",
        "output": "794"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.COc1cc(C(O)C(F)(F)F)ccc1Oc1cccc(F)n1>>Oc1cc(C(O)C(F)(F)F)ccc1Oc1cccc(F)n1",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CSCCCOc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C.ClCCl.O=C(OO)c1cccc(Cl)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc2c(F)c(Oc3ncnn4cc(OCCCS(C)=O)c(C)c34)ccc2[nH]1",
        "output": "13"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.CCN(CC)CC.CN(C)CCN.Clc1nc(-c2ccncc2)nc2sc3c(c12)CCCC3>>CN(C)CCNc1nc(-c2ccncc2)nc2sc3c(c12)CCCC3",
        "output": "723"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(OCC)[C@H](C)N(Cc1csc2ccccc12)C(=O)[C@@H](N)CC(=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1.O=C(O)CONC(=O)NCc1cccc2ccccc12>>CCOC(OCC)[C@H](C)N(Cc1csc2ccccc12)C(=O)[C@H](CC(=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1)NC(=O)CONC(=O)NCc1cccc2ccccc12",
        "output": "133"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CN(C)C=O.COc1ccc(C(=O)O)c(F)c1.O=C([O-])[O-].[K+].[K+]>>COc1ccc(C(=O)OCc2ccccc2)c(F)c1",
        "output": "403"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN1CCC(=O)CC1.ClCCCl.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCNCC1.O.O=C([O-])O.[Na+].[Na+]>>CN1CCC(N2CCC(n3nc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)CCCN(C)C(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)OC(C)(C)C)n1.ClCCl.O=C(O)C(F)(F)F>>CN(C)CCCN(C)C(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)O)n1",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNOC.Cl.ClCCl.O=C(O)c1ccncc1.O=C(n1ccnc1)n1ccnc1>>CON(C)C(=O)c1ccncc1",
        "output": "828"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC#CC(CC(=O)O)c1ccc(OC)nc1.Cl.O>>CC#CC(CC(=O)O)c1ccc(O)nc1",
        "output": "408"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)NCCN.Cn1c(S(C)(=O)=O)nc2ccccc21.O.[Na+].[OH-]>>CC(=O)NCCNc1nc2ccccc2n1C",
        "output": "629"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC(CCC)n1ccc2c(C(=O)O)cccc2c1=O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cl.Cl.ClCCl.N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(C(F)(F)F)c1.O.Oc1cccc2[nH]nnc12>>CCCC(CCC)n1ccc2c(C(=O)N[C@@H](Cc3ccccc3)[C@H](O)CNCc3cccc(C(F)(F)F)c3)cccc2c1=O",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.CCOC(C)=O.Cl.Cl.NCCn1ccc2ncnc(Nc3ccc(Oc4ccc5cn[nH]c5c4)c(Cl)c3)c21.O.O=C([O-])O.[Na+]>>CC(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4ccc5cn[nH]c5c4)c(Cl)c3)c21",
        "output": "339"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)C[C@@H]1C[C@H](C(=O)O)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc2c(n1)CCN[C@H]2C(=O)Nc1cc(F)c([Si](C)(C)C)c(F)c1.F[P-](F)(F)(F)(F)F.O>>COc1ccc2c(n1)CCN(C(=O)[C@@H]1C[C@H](CC(=O)OC(C)(C)C)C1)[C@H]2C(=O)Nc1cc(F)c([Si](C)(C)C)c(F)c1",
        "output": "297"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)O.N#Cc1cc(F)ccc1Br.O.OB(O)c1c(F)cccc1F.[F-].[K+]>>N#Cc1cc(F)ccc1-c1c(F)cccc1F",
        "output": "837"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCOCCOCCOCCO1.CC1(C)CCC(C)(C)c2cc(CC#Cc3ccc(C(=O)O)cc3)ccc21.CCCCCCI.CN(C)C=O.O.O=C([O-])O.[Na+]>>CCCCCCOC(=O)c1ccc(C#CCc2ccc3c(c2)C(C)(C)CCC3(C)C)cc1",
        "output": "196"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1cc(-n2cccn2)ccc1Br.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cc(-n2cccn2)ccc1B1OC(C)(C)C(C)(C)O1",
        "output": "942"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1cccc2c1Oc1cc(-c3noc(=O)[nH]3)ccc1C2=C1CC2CCC(C1)N2C(=O)C(F)(F)F.ClCCl>>O=C(N1C2CCC1CC(=C1c3ccc(-c4noc(=O)[nH]4)cc3Oc3c(O)cccc31)C2)C(F)(F)F",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.Cc1cc(C)c(-n2cc(C)c(C#N)c2N)c(C)c1>>CC(=O)Nc1c(C#N)c(C)cn1-c1c(C)cc(C)cc1C",
        "output": "394"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCNC(=O)[C@@H](N)CSCc1ccccc1.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.O=C(O)c1cc2cccc(NS(=O)(=O)c3cccs3)c2[nH]1.On1nnc2ccccc21>>CCCNC(=O)[C@H](CSCc1ccccc1)NC(=O)c1cc2cccc(NS(=O)(=O)c3cccs3)c2[nH]1",
        "output": "738"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCO.COc1ccc2nccc([C@@H](O)CN3CCC(N)CC3)c2c1.Cl.ClCCl.O=Cc1ccc2c(n1)NCCC2.O=S(=O)([O-])[O-].[BH4-].[Na+].[Na+].[Na+]>>COc1ccc2nccc([C@@H](O)CN3CCC(NCc4ccc5c(n4)NCCC5)CC3)c2c1",
        "output": "775"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1cnc(N)c(-c2cc3cc(N)ccc3s2)c1.O=C(O)c1ccc(F)c(Cl)c1>>COC(=O)c1cnc(N)c(-c2cc3cc(NC(=O)c4ccc(F)c(Cl)c4)ccc3s2)c1",
        "output": "50"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(NC[C@@H]1C[C@@H]2C[C@@H]2N1)c1cccc2occc12.O=C(O)c1ccccc1-c1cccc(Cl)c1>>O=C(NC[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)c1ccccc1-c1cccc(Cl)c1)c1cccc2occc12",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)OB(c2ccc(C(O)CC3CCCC3)cc2)OC1(C)C.COC(=O)CNc1ccc(-n2cc(-c3ccc(Cl)cc3Cl)nc2Cc2ccc(Br)cc2)cc1>>COC(=O)CNc1ccc(-n2cc(-c3ccc(Cl)cc3Cl)nc2Cc2ccc(-c3ccc(C(O)CC4CCCC4)cc3)cc2)cc1",
        "output": "933"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCc1cc(NC(=O)OC(C)(C)C)c(N)cc1C(F)(F)F.Cc1cc(-c2cccc(C(=O)CC(=O)OC(C)(C)C)c2)ccn1>>CCCc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3ccnc(C)c3)c2)cc1C(F)(F)F",
        "output": "929"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)N1CCN(c2cc(OC(F)(F)F)cc(C3OCCO3)c2)CC1.O.O=CO>>CC(C)N1CCN(c2cc(C=O)cc(OC(F)(F)F)c2)CC1",
        "output": "655"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1c(C(=O)N(C)c2ccc(OCc3ccccc3)cc2)cc(-c2cc3c(cc2C(=O)N2Cc4ccccc4C[C@H]2CN(C)C)CN(C(=O)Cc2ccccc2)CC3)n1C.[Pd]>>Cc1c(C(=O)N(C)c2ccc(O)cc2)cc(-c2cc3c(cc2C(=O)N2Cc4ccccc4C[C@H]2CN(C)C)CN(C(=O)Cc2ccccc2)CC3)n1C",
        "output": "698"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1cc(C[C@H]2C(=O)N(C(=O)Nc3ccccc3)[C@@H]2C(=O)OCc2ccccc2)ccn1.CCOC(C)=O.CO.[Pd]>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1cc(C[C@H]2C(=O)N(C(=O)Nc3ccccc3)[C@@H]2C(=O)O)ccn1",
        "output": "186"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCCCCCCOc1ccc2c(ccn2-c2ccccc2)c1.CCNCCO>>CCN(CCO)CCCCCCOc1ccc2c(ccn2-c2ccccc2)c1",
        "output": "73"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)c1ccccc1N=C=S.ClCCl.Nc1ccc(-c2ncn(-c3ccc(C(F)(F)F)cc3)n2)cc1>>CC(C)c1ccccc1NC(=S)Nc1ccc(-c2ncn(-c3ccc(C(F)(F)F)cc3)n2)cc1",
        "output": "474"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCc2oc3ccc(Br)cc3c2C1.O=c1cc(OCc2ccc(F)cn2)cc[nH]1>>CC(C)(C)OC(=O)N1CCc2oc3ccc(-n4ccc(OCc5ccc(F)cn5)cc4=O)cc3c2C1",
        "output": "349"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN(C)C=O.C[C@H]1COCCN1c1nc2c(c(-c3ccc(NC(=O)Oc4ccccc4)cc3)n1)CN(C(=O)OC(C)(C)C)C2.NCCO>>C[C@H]1COCCN1c1nc2c(c(-c3ccc(NC(=O)NCCO)cc3)n1)CN(C(=O)OC(C)(C)C)C2",
        "output": "488"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)C[C@@H]1COc2cc(N(C(=O)C(F)(F)F)C3COc4c(Nc5cc(F)ccc5[N+](=O)[O-])cccc43)ccc21.[C].[Pd]>>COC(=O)C[C@@H]1COc2cc(N(C(=O)C(F)(F)F)C3COc4c(Nc5cc(F)ccc5N)cccc43)ccc21",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)C1(c2cc(OCC(F)(F)F)c(Cl)c(-c3ccc(C(F)(F)F)cc3)c2)CCCC1.CO.O.[Li+].[OH-]>>O=C(O)C1(c2cc(OCC(F)(F)F)c(Cl)c(-c3ccc(C(F)(F)F)cc3)c2)CCCC1",
        "output": "615"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CCc1ccc([N+](=O)[O-])cc1Cl.[H][H].[Ni]>>CCN(CC)CCc1ccc(N)cc1Cl",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCCC.CCCc1ccc(Br)cc1.O=C([O-])[O-].OB(O)c1cc(F)cc(F)c1.[K+].[K+]>>CCCc1ccc(-c2cc(F)cc(F)c2)cc1",
        "output": "837"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#CC1(O)CCC1.CNC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(Br)cc1-2>>CNC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#CC3(O)CCC3)cc1-2",
        "output": "659"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.CCOC(=O)COc1ccc(CCC(NS(=O)(=O)c2ccc(Cl)cc2)c2cccnc2)cc1.[Na+].[OH-]>>O=C(O)COc1ccc(CCC(NS(=O)(=O)c2ccc(Cl)cc2)c2cccnc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)Nc1nc(COc2ccc(N)cc2)cs1.CCN=C=NCCCN(C)C.Cl.O=C(O)c1ccccc1-c1ccc(C(F)(F)F)cc1.On1nnc2ccccc21>>CC(=O)Nc1nc(COc2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cc2)cs1",
        "output": "817"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)n1ncc2c(C(=O)O)cc(N3CCC(N(C)C)CC3)cc21.CCCc1cc(C)[nH]c(=O)c1CN.CN1CCOCC1.CS(C)=O.ClCCCl.On1nnc2cccnc21>>CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(N2CCC(N(C)C)CC2)cc2c1cnn2C(C)C",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1ccc(-c2nc3ccccc3s2)cc1.O.O=C(Cl)c1ccccc1.c1ccncc1>>O=C(Nc1ccc(-c2nc3ccccc3s2)cc1)c1ccccc1",
        "output": "11"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(NC(=O)OC(C)(C)C)C(=O)N1CCS(=O)(=O)CC1.O=C(O)C(F)(F)F>>CC(N)C(=O)N1CCS(=O)(=O)CC1",
        "output": "431"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)S(=O)(=O)c1cc2c(Cl)ccnc2cc1O.FC(F)CI.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)S(=O)(=O)c1cc2c(Cl)ccnc2cc1OCC(F)F",
        "output": "198"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCc2nc(OC3CCN(C4CCCC4)CC3)ccc2C1.CCOC(C)=O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CN1CCc2nc(OC3CCN(C4CCCC4)CC3)ccc2C1",
        "output": "881"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CC[Al+]CC.Cc1ccccc1.N#Cc1ccccc1O.O.[Cl-].[Cl-].[N-]=[N+]=[N-].[Na+].[Na+]>>Oc1ccccc1-c1nnn[nH]1",
        "output": "390"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COc1cccc(NC(C(=O)c2c[nH]c3cc(O[Si](C)(C)C(C)(C)C)ccc23)c2ccccc2)c1.[Cs+].[F-]>>COc1cccc(NC(C(=O)c2c[nH]c3cc(O)ccc23)c2ccccc2)c1",
        "output": "754"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(Cc1ccc(NCCCCC(=O)N2CCOc3ccccc32)cc1)C(=O)OC.CO.Cl.O.O.O.[Li+].[OH-]>>CCOC(Cc1ccc(NCCCCC(=O)N2CCOc3ccccc32)cc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CN(C)C=O.Nc1ccc2ccc(-c3cccc(F)c3)nc2n1.O.O=C(O)c1cccc(Br)c1>>O=C(Nc1ccc2ccc(-c3cccc(F)c3)nc2n1)c1cccc(Br)c1",
        "output": "744"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COCCCl.CS(C)=O.O=C(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(-c3cccc(Cl)c3)c2c1.[H-].[Na+]>>COCCn1c(=O)cc(-c2cccc(Cl)c2)c2cc(C(=O)c3ccc(Cl)cc3)ccc21",
        "output": "42"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CI.Cc1cc(Br)ccc1O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(Br)cc1C",
        "output": "62"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccccn1.NCCCN>>NCCCNc1ccccn1",
        "output": "715"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CCOc1ccc(C(C)(C)CC=Cc2ccc(F)c(Oc3ccccc3)c2)cc1.[H][H].[Pd]>>CCOc1ccc(C(C)(C)CCCc2ccc(F)c(Oc3ccccc3)c2)cc1",
        "output": "362"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN1C(=O)Cc2cc(Br)ccc21.CS(C)=O.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CN1C(=O)Cc2cc(B3OC(C)(C)C(C)(C)O3)ccc21",
        "output": "942"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1CCCCN1CCN.O=C(O)c1ccc2c(=O)n(Cc3ccc(Cl)cc3)c(=O)[nH]c2c1>>CC1CCCCN1CCNC(=O)c1ccc2c(=O)n(Cc3ccc(Cl)cc3)c(=O)[nH]c2c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1cc([N+](=O)[O-])ccc1C(=O)O.O=S(=O)(O)O>>COC(=O)c1ccc([N+](=O)[O-])cc1C",
        "output": "33"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cnccc1Nc1nc(-c2cc(Cl)ccc2F)nc2c1CCCC2.[Na+].[OH-]>>O=C(O)c1cnccc1Nc1nc(-c2cc(Cl)ccc2F)nc2c1CCCC2",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCNc1nc(NCCO)nc2ccc([N+](=O)[O-])cc12.ClCCl.O=S(Cl)Cl>>C=CCNc1nc(NCCCl)nc2ccc([N+](=O)[O-])cc12",
        "output": "96"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)CCCOc1ccc(Br)cc1-c1cc(Cl)nc(N)n1.Nc1ccc(Cl)cc1>>CN(C)CCCOc1ccc(Br)cc1-c1cc(Nc2ccc(Cl)cc2)nc(N)n1",
        "output": "161"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)CC1(C(=O)O)CCN(C(=O)OC(C)(C)C)CC1.Cl>>CC(C)CC1(C(=O)O)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1=c2ccccc2=C(c2cccc3ccccc23)C(P(c2ccccc2)c2ccccc2)(P(c2ccccc2)c2ccccc2)C1.C1COCCN1.CC(C)(C)[O-].C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(Cl)c2ccccc12.ClCCl.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(N2CCOCC2)c2ccccc12",
        "output": "406"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCC.COC(=O)Cl.ClCCl.Nc1ccc(I)c([N+](=O)[O-])c1.c1ccncc1>>COC(=O)Nc1ccc(I)c([N+](=O)[O-])c1",
        "output": "102"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)c1ncc(-c2cccc(NC(=O)OCc3ccccc3)c2F)c2c1[nH]c1cc(OCCOC)ccc12.CO.O.O.[Li]O>>COCCOc1ccc2c(c1)[nH]c1c(C(=O)O)ncc(-c3cccc(NC(=O)OCc4ccccc4)c3F)c12",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)O.CC(C)(C)OC(=O)N1CC(c2ccc(N)cc2)C1.CCN(CC)CC.CO.ClCCCl.FC(F)(F)c1cnc(Cl)nc1Cl.[Cl-].[Cl-].[Zn+2]>>CC(C)(C)OC(=O)N1CC(c2ccc(Nc3ncc(C(F)(F)F)c(Cl)n3)cc2)C1",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(C)=O.NCCc1ccccc1.O.O=[N+]([O-])c1ccc(Cl)cc1>>O=[N+]([O-])c1ccc(NCCc2ccccc2)cc1",
        "output": "304"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)CNC(=O)c1cccc(F)c1F.Cl.O.[Li+].[OH-]>>O=C(O)CNC(=O)c1cccc(F)c1F",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1onc(-c2ccccc2)c1-c1cn2ccc(N)cc2n1.O=C(O)C1CCC1>>Cc1onc(-c2ccccc2)c1-c1cn2ccc(NC(=O)C3CCC3)cc2n1",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)N1CCN(C(=O)C2CCN(Cc3ccccc3)CC2)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(C)N1CCN(CC2CCN(Cc3ccccc3)CC2)CC1",
        "output": "112"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C[C@H](N)Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1.O=C(O)c1cc2n(n1)CCCC2>>C[C@@H](Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1)NC(=O)c1cc2n(n1)CCCC2",
        "output": "816"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(=O)(=O)NC[C@H]1CN(c2ccc(N3CCNCC3)c(F)c2)C(=O)O1.O=C(O)c1cn(C2CC2)c2nc(Cl)c(F)cc2c1=O>>CS(=O)(=O)NC[C@H]1CN(c2ccc(N3CCN(c4nc5c(cc4F)c(=O)c(C(=O)O)cn5C4CC4)CC3)c(F)c2)C(=O)O1",
        "output": "220"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)c1cc(SC(F)F)c(-c2ccc(Cl)cc2)[nH]1.Cl.O.[Na+].[OH-]>>O=C(O)c1cc(SC(F)F)c(-c2ccc(Cl)cc2)[nH]1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)Cn1nc(-c2ccc(F)cc2F)cc(COS(C)(=O)=O)c1=O.COC(=O)c1cc(-c2ccc(OC)c(F)c2)nn(CC=Cc2ccc(Cl)cc2)c1=O>>COc1ccc(-c2cc(C(=O)O)c(=O)n(CC=Cc3ccc(Cl)cc3)n2)cc1F",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Cc2c(C#N)ncc3c2c2cccnc2n3S(=O)(=O)c2ccccc2)CC1.ClCCl.O=C(O)C(F)(F)F>>N#Cc1ncc2c(c1CC1CCNCC1)c1cccnc1n2S(=O)(=O)c1ccccc1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.Cc1ccc(Cn2c(-c3ccc(Oc4ccc([N+](=O)[O-])cc4)cc3)cccc2=O)c(C)c1.Cc1ccccc1.O.O=C[O-].[Fe].[NH4+]>>Cc1ccc(Cn2c(-c3ccc(Oc4ccc(N)cc4)cc3)cccc2=O)c(C)c1",
        "output": "335"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)Cc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1.CO.[Na+].[OH-]>>CC(C)(C)OC(=O)C(C)(C)Sc1nc(CC(=O)O)cs1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Br.CC(=O)O.COc1cccc2c1Oc1ccccc1C21CCN(Cc2ccccc2)CC1>>Oc1cccc2c1Oc1ccccc1C21CCN(Cc2ccccc2)CC1",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Cc1nc2ccc(C(=O)O)cc2n1Cc1ccc(Cl)cc1Cl.ClCCl.N.O=C(Cl)C(=O)Cl>>Cc1nc2ccc(C(N)=O)cc2n1Cc1ccc(Cl)cc1Cl",
        "output": "358"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cl.ClCCl.Nc1cc(Br)ccc1Br.O=N[O-].O=S([O-])O.[I-].[K+].[Na+].[Na+]>>Brc1ccc(Br)c(I)c1",
        "output": "200"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(CCS)NC(=O)OCc1ccccc1.CN(C)C=O.COCCOCCOCCOCCBr.O=C([O-])[O-].[Cs+].[Cs+]>>COCCOCCOCCOCCSCCC(C)(C)NC(=O)OCc1ccccc1",
        "output": "185"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CC1C(CO)C1C(=O)OCC.CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>C=CC1C(C=O)C1C(=O)OCC",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)[C@@H](C(=O)N1CCC[C@H]1C(=O)Nc1ccc(CN(Cc2ccc(NC(=O)[C@@H]3CCCN3)cc2)c2ccc(F)cc2)cc1)c1ccccc1.COC(=O)N[C@H](C(=O)O)C(C)(C)C>>CCN(CC)[C@@H](C(=O)N1CCC[C@H]1C(=O)Nc1ccc(CN(Cc2ccc(NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)OC)C(C)(C)C)cc2)c2ccc(F)cc2)cc1)c1ccccc1",
        "output": "297"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(O)CC1(CC#N)CC1.CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(=O)CC1(CC#N)CC1",
        "output": "87"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1cc(C2CC2)c(OCC2CCN(Cc3cccc(F)c3)CC2)cc1F.COC(=O)c1cc(C2CC2)c(O[C@@H]2CCCN(CC3(C(F)(F)F)CCC3)C2)cc1F>>O=C(O)c1cc(C2CC2)c(O[C@@H]2CCCN(CC3(C(F)(F)F)CCC3)C2)cc1F",
        "output": "222"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2cccs2)cc1NC(=O)c1ccc(COP(C)(C)=O)cc1.ClCCl.O=C(O)C(F)(F)F>>CP(C)(=O)OCc1ccc(C(=O)Nc2cc(-c3cccs3)ccc2N)cc1",
        "output": "782"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "B.C1CCOC1.CC(C)(C)OC(=O)[C@@H]1CCCN1CC(=O)N1CCSc2cc([N+](=O)[O-])ccc21>>CC(C)(C)OC(=O)[C@@H]1CCCN1CCN1CCSc2cc([N+](=O)[O-])ccc21",
        "output": "112"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(Br)CC.CCOc1cc(C=O)ccc1C.CCOc1cc(C=O)ccc1O.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOc1cc(C=O)ccc1OC(CC)CC",
        "output": "153"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1.O=C(Cl)c1c[nH]c2ccccc12.O=C(O)c1c[nH]c2ccccc12>>O=C1CC(=O)N(c2ccc(NC(=O)c3c[nH]c4ccccc34)cc2)c2ccc3ccccc3c2N1",
        "output": "642"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCCCCCN(C)CCOc1ccc(CCC(=O)OC)cc1.CCO.Cl.O.[K+].[OH-]>>CCCCCCCCCCCCN(C)CCOc1ccc(CCC(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CS(=N)(=O)Cc1cncc(C2COc3c(cccc3C(N)=O)O2)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CS(=N)(=O)Cc1cncc(C2COc3c(C#N)cccc3O2)c1",
        "output": "374"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)CN(C)C(=O)CNC(=O)OC(C)(C)C.Cl.O.O.[Li+].[OH-]>>CN(CC(=O)O)C(=O)CNC(=O)OC(C)(C)C",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CC(=O)CCC1C(=O)O.CO.C[Si](C)(C)C=[N+]=[N-].Cc1ccccc1>>COC(=O)C1CCC(=O)CN1C(=O)OC(C)(C)C",
        "output": "195"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C1CCOC1.N#CC(O)c1cccc2ccccc12.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCC(O)c1cccc2ccccc12",
        "output": "246"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNC1.CCOC(=O)Cn1c(C)c(Sc2ccc(Br)cc2S(=O)(=O)Cl)c2c1CC(C)(C)CC2=O.ClCCl>>CCOC(=O)Cn1c(C)c(Sc2ccc(Br)cc2S(=O)(=O)N2CCCC2)c2c1CC(C)(C)CC2=O",
        "output": "99"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)C1(c2cc(Cl)c(-c3ccc(C(F)(F)F)cc3)c(OCC(F)(F)F)c2)CCCC1.CO.O.[Li+].[OH-]>>O=C(O)C1(c2cc(Cl)c(-c3ccc(C(F)(F)F)cc3)c(OCC(F)(F)F)c2)CCCC1",
        "output": "615"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)N(C)C.CCOP(=O)(CC(=O)O)OCC.CO.ClCCl.Nc1cc2c(Nc3ccc(Br)c(Cl)c3)ncnc2cn1.O.O=C(n1ccnc1)n1ccnc1>>CCOP(=O)(CC(=O)Nc1cc2c(Nc3ccc(Br)c(Cl)c3)ncnc2cn1)OCC",
        "output": "368"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(CC)CC.Cc1ccc(N)cc1Br.Nc1cccc(C(F)(F)F)c1.O.O=C(Cl)c1cccc(C(F)(F)F)c1>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Br",
        "output": "11"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C)(C(=O)OCC)c1ccc(N)cc1.Cc1ccccc1C.Cl.ClCCNCCCl>>CCOC(=O)C(C)(C(=O)OCC)c1ccc(N2CCNCC2)cc1",
        "output": "640"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.C1CNCCN1.CC(C)(C)[O-].Clc1ccc(Br)c(Cl)c1.[Na+].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Clc1ccc(N2CCNCC2)c(Cl)c1",
        "output": "294"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)OC(=O)N1CCC(CO)CC1.CCCC(C)C.CCCCP(CCCC)CCCC.Cc1ccccc1.Oc1ccc(Br)nc1>>CC(C)OC(=O)N1CCC(COc2ccc(Br)nc2)CC1",
        "output": "547"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CO.N#CC1C(=O)NC(=O)C(C(=O)OCc2ccccc2)C12CCCCC2.[Pd]>>N#CC1C(=O)NC(=O)C(C(=O)O)C12CCCCC2",
        "output": "186"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(N)cc(OC2CCOC2)c1.COc1cc(OCC2CCCO2)cc([N+](=O)[O-])c1>>COc1cc(N)cc(OCC2CCCO2)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOCCOC(=O)Cl.Nc1ccc(-c2cnc([C@@H]3CCc4cc(-c5cc(Cl)ccc5-n5cnnn5)cc(=O)n43)[nH]2)cc1>>CCOCCOC(=O)Nc1ccc(-c2cnc([C@@H]3CCc4cc(-c5cc(Cl)ccc5-n5cnnn5)cc(=O)n43)[nH]2)cc1",
        "output": "102"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(c1ccc([N+](=O)[O-])cc1)n1cnnc1.CO.[C].[H][H].[Pd]>>CC(=O)N(c1ccc(N)cc1)n1cnnc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)=O.CC(C)[Mg]Cl.Cc1cc(F)cc(Br)c1Br.O=C=O.O=C=O.[Na+].[OH-]>>Cc1cc(F)cc(C(=O)O)c1Br",
        "output": "654"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(NC(N)=S)ccc1-n1cnc(C)c1.COc1ccccc1C(=O)CBr>>COc1ccccc1-c1csc(Nc2ccc(-n3cnc(C)c3)c(OC)c2)n1",
        "output": "716"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.N.N#Cc1cccc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c1.[Ni]>>NCc1cccc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c1",
        "output": "175"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCCC2)CC1.O=C(O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccccc2)cc1>>O=C(N[C@@H]1CC[C@@H](CCN2CCCC2)CC1)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccccc2)cc1",
        "output": "835"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C=CC(=O)Cl.CCN(CC)CC.CN(C)C=O.N#Cc1cnc2ccc(N)cc2c1Nc1ccc(Sc2ccccc2)c(Cl)c1.O=C([O-])O.[Na+]>>C=CC(=O)Nc1ccc2ncc(C#N)c(Nc3ccc(Sc4ccccc4)c(Cl)c3)c2c1",
        "output": "10"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC(CO)C(c2ccccc2)C1.CCN(C(C)C)C(C)C.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)N1CC(C=O)C(c2ccccc2)C1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCC2=NCCCN2CC1.C1CCOC1.CCCCCN(Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1)C(=O)N1CCc2ccccc21.O=C(O)c1ccccc1Cl.O=C(n1ccnc1)n1ccnc1>>CCCCCN(Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1)C(=O)N1CCc2ccccc21",
        "output": "579"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)c1ccc(Cl)c(CO)c1.NCCC1CCN(c2ccncc2)CC1.O=C(NCCC1CCN(c2ccncc2)CC1)c1cccc(-c2nc3c(Cl)cccc3s2)c1.O=C(O)C(F)(F)F.O=C(O)c1ccc(Cl)c(-c2nc3c(Cl)cccc3[nH]2)c1.OBO>>O=C(NCCC1CCN(c2ccncc2)CC1)c1ccc(Cl)c(-c2nc3c(Cl)cccc3[nH]2)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.Cc1cccc(-c2sc(C)nc2C(=O)N2[C@H]3C[C@H]3C[C@H]2CN)c1.O=C(Cl)c1cccc2sc(Cl)nc12>>Cc1cccc(-c2sc(C)nc2C(=O)N2[C@H]3C[C@H]3C[C@H]2CNC(=O)c2cccc3sc(Cl)nc23)c1",
        "output": "353"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)CN.CCOC(=O)C(C)c1ccc(C#N)cc1.C[Al](C)C.ClCCl>>CC(C(=O)NCC(C)(C)C)c1ccc(C#N)cc1",
        "output": "64"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COC(=O)Cc1c(Cl)nc(Cc2ccc(N)cc2)nc1N(C)C.F[P-](F)(F)(F)(F)F.O.O=C(O)c1ccc2ccccc2c1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>COC(=O)Cc1c(Cl)nc(Cc2ccc(NC(=O)c3ccc4ccccc4c3)cc2)nc1N(C)C",
        "output": "50"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1NCCc2cccc(-c3ccncc3)c21.O=C(O)c1cc2ncc(Br)cn2n1>>CN1c2c(cccc2-c2ccncc2)CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "995"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.CS(C)=O.Cc1ccccc1CN(Cc1ccccc1C)[C@H](CO)Cc1cc(F)cc(F)c1.O>>Cc1ccccc1CN(Cc1ccccc1C)[C@H](C=O)Cc1cc(F)cc(F)c1",
        "output": "142"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCCCCCBr.OCCCCCc1ccccc1>>BrCCCCCOCCCCCc1ccccc1",
        "output": "95"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1nc(-c2noc3c(F)c(N4C[C@H](C)O[C@H](C)C4)c(CO)cc23)co1.ClCCl.O=[Mn]=O>>Cc1nc(-c2noc3c(F)c(N4C[C@H](C)O[C@H](C)C4)c(C=O)cc23)co1",
        "output": "179"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.Cl>>CCCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)c1cc(Br)c(C)cc1OCc1ccccc1.O.[Li+].[OH-]>>Cc1cc(OCc2ccccc2)c(C(=O)O)cc1Br",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1cc(C(=O)NCc2ccc([N+](=O)[O-])cc2)cc(C(C)(C)C)c1O.O=C(NCCc1ccc([N+](=O)[O-])cc1)c1cc(O)c(O)c(O)c1>>Nc1ccc(CCNC(=O)c2cc(O)c(O)c(O)c2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(C)=O.CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)N(CC=O)C(=O)OC(C)(C)C.[BH4-].[Na+]>>CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)N(CCO)C(=O)OC(C)(C)C",
        "output": "223"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1CN(C)CCN1.CCN(C(C)C)C(C)C.CN(C)C=O.O=C(CCl)Nc1cc(C(=O)Nc2ccc(-c3ccccc3F)nc2)ccc1OC(F)(F)F.[I-].[K+]>>CC1CN(C)CCN1CC(=O)Nc1cc(C(=O)Nc2ccc(-c3ccccc3F)nc2)ccc1OC(F)(F)F",
        "output": "340"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)O.O=Cc1cc([N+](=O)[O-])ccc1F.OC[C@@H]1CCCN1.[BH3-]C#N.[Na+]>>O=[N+]([O-])c1ccc(F)c(CN2CCC[C@H]2CO)c1",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC2CNCC2C1.Cc1ccccc1.O=C(Cl)c1c(F)cccc1-n1nccn1.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)OC(=O)N1CC2CN(C(=O)c3c(F)cccc3-n3nccn3)CC2C1",
        "output": "201"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cc(-c2ccccc2OCc2ccccc2)n(C)n1.CO.[Pd]>>CCOC(=O)c1cc(-c2ccccc2O)n(C)n1",
        "output": "23"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCCC[C@@]1(C)C(=O)O.CCN(C(C)C)C(C)C.CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC)OC)N(C)C(=O)[C@@H](N)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.ClCCl.F[P-](F)(F)(F)(F)F>>CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC)OC)N(C)C(=O)[C@@H](NC(=O)[C@]1(C)CCCCN1C(=O)OC(C)(C)C)C(C)C",
        "output": "131"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1ccc(COP(=O)(OC(C)(C)C)OC(C)(C)C)cc1.O.[Li+].[OH-]>>CC(C)(C)OP(=O)(OCc1ccc(C(=O)O)cc1)OC(C)(C)C",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)N1CCC(Oc2ccc3[nH]c(C(=O)O)cc3c2)CC1.O=S1(=O)CCNCC1.[Cl-].[Li+]>>CC(C)N1CCC(Oc2ccc3[nH]c(C(=O)N4CCS(=O)(=O)CC4)cc3c2)CC1",
        "output": "605"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.Nc1ccccn1.O=C(O)C(SC1CCCC1)c1cccc(OC(F)(F)F)c1>>O=C(Nc1ccccn1)C(SC1CCCC1)c1cccc(OC(F)(F)F)c1",
        "output": "368"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCN(CCCC)C(=O)c1cn(CC(=O)O)c(-c2ccc(C(=O)OC)cc2C(=O)N2CCc3ccccc3C2)n1.CCN(C(C)C)C(C)C.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O>>CCCCN(CCCC)C(=O)c1cn(CC(=O)NC)c(-c2ccc(C(=O)OC)cc2C(=O)N2CCc3ccccc3C2)n1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)[C@@H](N)COC1CCOCC1.F[P-](F)(F)(F)(F)F.Nc1cc2ccccc2cc1C(=O)O>>COC(=O)[C@H](COC1CCOCC1)NC(=O)c1cc2ccccc2cc1N",
        "output": "652"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2ccc([N+](=O)[O-])c(F)c2)CC1.CO.[Pd]>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(N)c(F)c2)CC1",
        "output": "202"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)Cc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.Cc1noc(-c2ccc(Br)cc2)c1NC(=O)O[C@@H](C)c1ccccc1Cl>>CCOC(=O)Cc1ccc(-c2ccc(-c3onc(C)c3NC(=O)O[C@@H](C)c3ccccc3Cl)cc2)cc1",
        "output": "933"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Cc1ccc(C(=O)O)cc1.O=C(Cl)C(=O)Cl.c1ccccc1>>Cc1ccc(C(=O)Cl)cc1",
        "output": "448"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCCO.CCCc1nc2c(N)nc3cc(Br)ccc3c2s1.O.O=C([O-])[O-].OCc1ccccc1B(O)O.[Na+].[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCc1nc2c(N)nc3cc(-c4ccccc4CO)ccc3c2s1",
        "output": "909"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNC1.Cc1cccc(-c2nc3ccc(Cl)cn3c2-c2ccnc(-c3ccc(C=O)cc3)c2)n1>>Cc1cccc(-c2nc3ccc(Cl)cn3c2-c2ccnc(-c3ccc(CN4CCCC4)cc3)c2)n1",
        "output": "567"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=[N+]([O-])c1cccc(Br)c1Cl.[Cl-].[NH4+].[Zn]>>Nc1cccc(Br)c1Cl",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C[AlH]CC(C)C.CCOC(=O)CC1CCCc2c1cnn2-c1ccc(Cl)c(Cl)c1.Cc1ccccc1.ClCCl.O>>OCCC1CCCc2c1cnn2-c1ccc(Cl)c(Cl)c1",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "OB(O)c1ccc(C(F)(F)F)cc1.Oc1ccc2c(c1)OCc1c-2nc2ccc(O)cc2c1Br>>Oc1ccc2c(c1)OCc1c-2nc2ccc(O)cc2c1-c1ccc(C(F)(F)F)cc1",
        "output": "872"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)c1c(OCC=C(C)C)ccc2c(=O)c(C)c(-c3ccccc3)oc12.CCO.O.O=Cc1ccccc1.[K+].[OH-]>>CC(C)=CCOc1ccc2c(=O)c(C)c(-c3ccccc3)oc2c1C(=O)C=Cc1ccccc1",
        "output": "295"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(CC)CC.CNCCCN1CCOCC1.COc1cc([N+](=O)[O-])ccc1S(=O)(=O)Cl>>COc1cc([N+](=O)[O-])ccc1S(=O)(=O)N(C)CCCN1CCOCC1",
        "output": "99"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(C)=O.CC[O-].CO.ClCCCCBr.O=C(c1ccccc1)c1ccc(O)cc1.[Na+]>>O=C(c1ccccc1)c1ccc(OCCCCCl)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1cccc(N)c1.Cc1cc(Cl)nc(N)n1.Cl.O.[K+].[OH-]>>CC(=O)c1cccc(Nc2cc(C)nc(N)n2)c1",
        "output": "161"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1ccc2c(c1)CNCC2.C=O.O=CO>>CN1CCc2ccc(Br)cc2C1",
        "output": "69"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1c(F)cc(Br)cc1F.CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].CCO.N.[BH4-].[NH4+].[Na+].[OH-].[Ti+4]>>CC(N)c1c(F)cc(Br)cc1F",
        "output": "552"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "B.C1CCOC1.C1CCOC1.COc1ccc2cccc(C(=O)O)c2c1>>COc1ccc2cccc(CO)c2c1",
        "output": "72"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O.O=Cc1ccc2ccccc2n1.[BH4-].[Na+]>>OCc1ccc2ccccc2n1",
        "output": "745"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1cncn1C.Cl.[Na+].[OH-]>>Cn1cncc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Clc1ccc(Br)cn1.O=C(OCc1ccccc1)N1C[C@@H]2CN[C@@H]2C1>>O=C(OCc1ccccc1)N1C[C@@H]2CN(c3ccc(Cl)nc3)[C@@H]2C1",
        "output": "597"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCN)c2cc1C.O=C(O)C(F)(F)F.O=Cc1ccc2ccccc2c1>>Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCNCc3ccc4ccccc4c3)c2cc1C",
        "output": "468"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)C(CC1CCCC1)c1ccc(S(=O)(=O)CC)cc1.[Li+].[OH-]>>CCS(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)[C@@H]1CN(C(=O)C2(c3ccc(Cl)cc3)CC2)C[C@H]1c1ccccc1.O.[Li+].[OH-]>>O=C(O)[C@@H]1CN(C(=O)C2(c3ccc(Cl)cc3)CC2)C[C@H]1c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CCc1c(C(=O)O)cc(Cl)cc1N(C)C1CCOCC1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1cc(C)c(CN)c(=O)[nH]1.F[P-](F)(F)(F)(F)F>>CCc1c(C(=O)NCc2c(C)cc(C)[nH]c2=O)cc(Cl)cc1N(C)C1CCOCC1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.NCCc1ccccn1.O.O=C(O)c1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1>>O=C(NCCc1ccccn1)c1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)COc1cc(F)cc(S(C)(=O)=O)c1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCN.ClCCCl.[Na+]>>CCCNC(C)COc1cc(F)cc(S(C)(=O)=O)c1",
        "output": "236"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(CO)CO[Si](C)(C)C(C)(C)C.ClCCl>>CC(C)(C=O)CO[Si](C)(C)C(C)(C)C",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.O.O=Cc1ccc2c([N+](=O)[O-])cccc2n1.[BH4-].[Na+]>>O=[N+]([O-])c1cccc2nc(CO)ccc12",
        "output": "745"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)[C@H]1CC[C@@H](Nc2c(C(=O)C3CC3)cnc3ccc(Br)cc23)CC1.COc1cc(B2OC(C)(C)C(C)(C)O2)cc(Cl)c1O>>CCN(CC)[C@H]1CC[C@@H](Nc2c(C(=O)C3CC3)cnc3ccc(-c4cc(Cl)c(O)c(OC)c4)cc23)CC1",
        "output": "933"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)c1nnc2ccc(Cl)nn12.CN(C)C=O.NCCCN1CCC(OC(c2ccccc2)c2ccccc2)CC1.O.[Cl-].[Na+]>>CCOC(=O)c1nnc2ccc(NCCCN3CCC(OC(c4ccccc4)c4ccccc4)CC3)nn12",
        "output": "241"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)Cl.ClCCl.Nc1ccccc1CO.c1ccncc1>>CS(=O)(=O)Nc1ccccc1CO",
        "output": "194"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.N#CCc1ccc(Cl)c(Cl)c1.[NH4+].[Ni].[OH-]>>NCCc1ccc(Cl)c(Cl)c1",
        "output": "246"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.COC1CCNCC1.Cc1ccc(-c2cc(C(=O)O)nn2-c2cnccn2)nc1.Cl.Cl.ClCCl.On1nnc2ccccc21>>COC1CCN(C(=O)c2cc(-c3ccc(C)cn3)n(-c3cnccn3)n2)CC1",
        "output": "663"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCC.CCS.COC(=O)c1nc(C)sc1-c1cccc(OCc2ccccc2)c1.FB(F)F.[Na+].[OH-]>>COC(=O)c1nc(C)sc1-c1cccc(O)c1",
        "output": "23"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCO.CCOC(=O)C1CCN(c2cnccc2-n2cc(Cl)cn2)CC1.Cl.[Na+].[OH-]>>O=C(O)C1CCN(c2cnccc2-n2cc(Cl)cn2)CC1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CNC(=O)c1nc(-c2cccc(C(=O)O)c2)cnc1N.NCCNc1ccccc1>>CNC(=O)c1nc(-c2cccc(C(=O)NCCNc3ccccc3)c2)cnc1N",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCC(=O)CCNC(CCCCCCC(=O)OCC)C(=O)OCC.CCO.[BH4-].[Na+]>>CCCCCC(O)CCNC(CCCCCCC(=O)OCC)C(=O)OCC",
        "output": "91"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCCCCNC(=O)c1cnc(OCC2CO2)s1.CC(C)(C)N.CCO>>C#CCCCCNC(=O)c1cnc(OCC(O)CNC(C)(C)C)s1",
        "output": "16"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl.OCCCC1CCCCN1Cc1ccccc1>>O=CCCC1CCCCN1Cc1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCI.CCOC(C)=O.CN(C)C=O.O=C(O)c1cccc2c1CC(=CCCN1CCC(O)(c3ccc(Cl)cc3)CC1)c1cccnc1O2.O=C([O-])[O-].[K+].[K+]>>CCCOC(=O)c1cccc2c1CC(=CCCN1CCC(O)(c3ccc(Cl)cc3)CC1)c1cccnc1O2",
        "output": "196"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCCCCCCC(=O)N1CCC(CCON2C(=O)c3ccccc3C2=O)CC1.CCO.NN.O>>CCCCCCCCCCCCCCCC(=O)N1CCC(CCON)CC1",
        "output": "452"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(O)CCC[C@@]1(C)[C@H](OCc2ccccc2)CCCC12OCCO2.CCOCC.ClCCl.[Cr+6].[O-2].[O-2].[O-2].c1ccncc1>>CC(=O)CCC[C@@]1(C)[C@H](OCc2ccccc2)CCCC12OCCO2",
        "output": "87"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)O[K].CCOC(=O)C1CCNCC1.COc1ccc(Cl)nc1.Cc1ccccc1.c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CCOC(=O)C1CCN(c2ccc(OC)cn2)CC1",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.Cc1cccc([N+](=O)[O-])c1Cl.[Fe]>>Cc1cccc(N)c1Cl",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)CN(CCCOc1ccc2c(ccc(=O)n2C)c1)Cc1ccncc1.CO.Cl.[Na+].[OH-]>>Cn1c(=O)ccc2cc(OCCCN(CC(=O)O)Cc3ccncc3)ccc21",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.N#CC[C@@H](O)CC(=O)O.O=C([O-])[O-].O=S(=O)(O)O.[Na+].[Na+]>>CCOC(=O)C[C@H](O)CC#N",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.CNC(=O)C(F)(C1CCc2c([nH]c3ccc(Cl)cc23)C1)S(=O)(=O)c1ccccc1.ClCCl>>CNC(=O)C(F)(C1CCc2c(n(C(=O)OC(C)(C)C)c3ccc(Cl)cc23)C1)S(=O)(=O)c1ccccc1",
        "output": "748"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.O=S(=O)(Oc1ccc2cc(CO)ccc2c1)C(F)(F)F.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>O=Cc1ccc2cc(OS(=O)(=O)C(F)(F)F)ccc2c1",
        "output": "179"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCC(C(=O)O)(c2ccccc2)CC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CI>>COC(=O)C1(c2ccccc2)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "415"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COc1ccc([N+](=O)[O-])c(C(=O)O)c1OC.[Pd]>>COc1ccc(N)c(C(=O)O)c1OC",
        "output": "202"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)C(C(=O)OC2CCCC2)C1.ClCCl.O=C(O)C(F)(F)F>>O=C(OC1CCCC1)C1CNCCN1C(=O)OCc1ccccc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CC[O-].CCc1c(C)c(Cl)nn2c(N)nnc12.O.[Na+]>>CCOc1nn2c(N)nnc2c(CC)c1C",
        "output": "407"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)Cc1ccc(Cl)c2nc(C(C)C)c(Cc3ccc(-n4cccn4)cc3)c(C)c12.[Li+].[OH-]>>Cc1c(Cc2ccc(-n3cccn3)cc2)c(C(C)C)nc2c(Cl)ccc(CC(=O)O)c12",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(OCC)OCC.Cc1ccc(S(=O)(=O)O)cc1.O=C([O-])O.O=C1CC(c2cccc(Cl)c2)Oc2ccc(Br)cc21.OCCO.[Na+].c1ccccc1>>Clc1cccc(C2CC3(OCCO3)c3cc(Br)ccc3O2)c1",
        "output": "93"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1cccc(Br)c1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].Cc1ccccc1.[Na+].[Pd+2].c1ccc(Nc2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Brc1cccc(N(c2ccccc2)c2ccccc2)c1",
        "output": "894"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.Cn1ncc(Cl)c1-c1cc(N)ccc1OCCN1CCOCC1.O=C=Nc1cccc(Cl)c1>>Cn1ncc(Cl)c1-c1cc(NC(=O)Nc2cccc(Cl)c2)ccc1OCCN1CCOCC1",
        "output": "804"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCCCCC(=O)Cl.Cl.ClCCl.N[C@H]1CCCNC(=O)C1.O.O=C([O-])[O-].[Na+].[Na+]>>CCCCCCCCCCCC(=O)N[C@H]1CCCNC(=O)C1",
        "output": "45"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCC(O)/C=C/c1ccccc1CCCCCCC(=O)OC.CO.O.O=C([O-])[O-].[K+].[K+]>>CCCCCC(O)/C=C/c1ccccc1CCCCCCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCCOc1cc(F)c(N)cc1S(=O)(=O)N1CCCCc2ccccc21.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(=O)c1cc(C)c2[nH]c(=O)n(-c3cc(S(=O)(=O)N4CCCCc5ccccc54)c(OCCO[Si](C)(C)C(C)(C)C)cc3F)c2n1.Cl.[F-]>>CCOC(=O)c1cc(C)c2[nH]c(=O)n(-c3cc(S(=O)(=O)N4CCCCc5ccccc54)c(OCCO)cc3F)c2n1",
        "output": "708"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(Cn2nc(C)c3c(Oc4ccc(NC(=O)Nc5ccccn5)cc4F)ccnc32)cc1.O=C(O)C(F)(F)F>>Cc1n[nH]c2nccc(Oc3ccc(NC(=O)Nc4ccccn4)cc3F)c12",
        "output": "978"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "NC1CCCc2ccccc21.O=C(O)c1ccc2c(c1)OCO2>>O=C(NC1CCCc2ccccc21)c1ccc2c(c1)OCO2",
        "output": "753"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccc(O)cc1.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[K+].[K+]>>CC(=O)c1ccc(Oc2ccc([N+](=O)[O-])cc2)cc1",
        "output": "564"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CC(CC(C)C)C(=O)N[C@@H](Cc1ccc(OC)cc1)C(=O)NC.CO.[K+].[OH-]>>CNC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)C(CC(=O)O)CC(C)C",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccc(SCC(CCC(=O)O)C(=O)O)cc1C>>COC(=O)CCC(CSc1ccc(C)c(C)c1)C(=O)O",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.COc1ccc(CBr)cc1.Cc1cccc(C(C)c2ncc[nH]2)c1C.ClCCl.O>>COc1ccc(Cn2ccnc2C(C)c2cccc(C)c2C)cc1",
        "output": "593"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCC.CO.O=C([O-])O.O=C1CCC(=O)O1.[Na+]>>COC(=O)CCC(=O)O",
        "output": "139"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)P([c-]1cccc1)C(C)(C)C.CC(C)(C)P([c-]1cccc1)C(C)(C)C.Cl[Pd]Cl.N#Cc1cnc(Cl)nc1N.O=P([O-])([O-])[O-].OB(O)c1ccccc1.[Fe+2].[K+].[K+].[K+].[Pd+2]>>N#Cc1cnc(-c2ccccc2)nc1N",
        "output": "874"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)CCn1c(C(=O)OCC)cc2ccccc21>>CCOC(=O)c1cc2ccccc2n1CCCO",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NC1CCc2ccc(CN)cc2C1Cc1ccccc1.CN(C)c1ccncc1.ClCCl.O=S(=O)(Cl)CCCF>>CC(C)(C)OC(=O)NC1CCc2ccc(CNS(=O)(=O)CCCF)cc2C1Cc1ccccc1",
        "output": "742"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Nc1ccc(O)cc1[N+](=O)[O-].ClCC1CO1.[Na+].[OH-]>>CC(=O)Nc1ccc(OCC2CO2)cc1[N+](=O)[O-]",
        "output": "15"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)O.CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.CNC(=O)c1cccc(Cl)c1Nc1nc(Cl)ncc1Cl.COCCN1C(=O)CCCc2cc(N)ccc21.O.O=C([O-])O.[Na+]>>CNC(=O)c1cccc(Cl)c1Nc1nc(Nc2ccc3c(c2)CCCC(=O)N3CCOC)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.Cn1ncnc1-c1ccc(F)cc1CO.O=[Mn]=O>>Cn1ncnc1-c1ccc(F)cc1C=O",
        "output": "179"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)Cc1ccc(F)c(C#N)c1.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].[K+].[K+].c1c[nH]cn1>>CC(C)(C)Cc1ccc(-n2ccnc2)c(C#N)c1",
        "output": "701"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1cccc([C@H]2CC(O)C[C@@H](c3ccccc3)O2)c1.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>COC(=O)c1cccc([C@H]2CC(=O)C[C@@H](c3ccccc3)O2)c1",
        "output": "87"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COCCC(NC(=O)OC(C)(C)C)c1ccc(Cl)cc1.Cl.ClCCl>>COCCC(N)c1ccc(Cl)cc1",
        "output": "793"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)[O-].CN(C(=O)CCl)C1CCN(Cc2ccccc2)CC1.O.Oc1cccc(Cl)c1.[K+]>>CN(C(=O)COc1cccc(Cl)c1)C1CCN(Cc2ccccc2)CC1",
        "output": "458"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc(Cl)ccc1C(=O)O.O=S(Cl)Cl>>COc1cc(Cl)ccc1C(=O)Cl",
        "output": "3"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)C(C)(C)C1CCC(F)(F)CC1.O.[Na+].[OH-]>>CC(C)(C(=O)O)C1CCC(F)(F)CC1",
        "output": "281"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCNCC1.CCO.Cc1c(C=O)[nH]c2c1C(=O)N(C[C@@H](O)CN1CCOCC1)CCC2.O=C1Cc2cc(F)cc(Br)c2N1>>Cc1c(/C=C2\\C(=O)Nc3c(Br)cc(F)cc32)[nH]c2c1C(=O)N(C[C@@H](O)CN1CCOCC1)CCC2",
        "output": "911"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCc2c(sc3ccc(Br)cc23)C1.O=c1cc(OCc2ccc(F)cn2)cc[nH]1>>CC(C)(C)OC(=O)N1CCc2c(sc3ccc(-n4ccc(OCc5ccc(F)cn5)cc4=O)cc23)C1",
        "output": "349"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)C#C[Si](C)(C)C.CC(O)(C#C[Si](C)(C)C)c1ccc(F)cn1.CCOCC.CO.Fc1ccc(Br)nc1.O=C([O-])[O-].[K+].[K+].[Li]C(C)CC>>C#CC(C)(O)c1ccc(F)cn1",
        "output": "337"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Cc1c(O)ccc2c1CCNCC2>>Cc1c(O)ccc2c1CCN(C(=O)OC(C)(C)C)CC2",
        "output": "694"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)c1n[nH]c(SCCO)n1.CCN(CC)CC.ClC(Cl)Cl.O=C=Nc1ccc(C(F)(F)F)cc1>>CC(C)(C)c1n[nH]c(SCCOC(=O)Nc2ccc(C(F)(F)F)cc2)n1",
        "output": "34"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1ccc(-n2nc(C(C)(C)C)oc2=O)cc1.ClCCl>>CC(C)(C)c1nn(-c2ccc(O)cc2)c(=O)o1",
        "output": "402"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C(=O)c1ccc(-c2cnc(N)c(-c3nnc(-c4cccc(CNC(=O)OC(C)(C)C)c4)o3)n2)cc1.CO.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O>>CN(C)C(=O)c1ccc(-c2cnc(N)c(-c3nnc(-c4cccc(CN)c4)o3)n2)cc1",
        "output": "793"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCC.Fc1ccc(C2(c3ccc(Cl)cc3Cl)Oc3cc(F)c(Br)cc3O2)cc1.O=C=O.[Li]CCCC>>O=C(O)c1cc2c(cc1F)OC(c1ccc(F)cc1)(c1ccc(Cl)cc1Cl)O2",
        "output": "654"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.C1COCCO1.CO.Nc1nc(N2CCCNCC2)c2nc(-c3ccc(F)cc3)[nH]c2n1.O=C(Cl)COc1ccc(Cl)cc1.O=C([O-])[O-].[K+].[K+]>>Nc1nc(N2CCCN(C(=O)COc3ccc(Cl)cc3)CC2)c2nc(-c3ccc(F)cc3)[nH]c2n1",
        "output": "125"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1cc(Cl)c(Br)cc1F.ClCCCl.O=C1CCC(=O)N1Br>>Fc1cc(Br)c(Cl)cc1CBr",
        "output": "29"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)O)cc(F)c3C)cc12.Cl.ClCCl.NC1(c2ccccn2)CC1.On1nnc2ccccc21>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5ccccn5)CC4)cc(F)c3C)cc12",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)Cn1c(=O)[nH]c(=O)c2c(-c3nccn3C)n(Cc3c[nH]c4ccc(Cl)cc34)nc21.O=C([O-])[O-].OCCBr.[K+].[K+]>>CC(C)Cn1c(=O)n(CCO)c(=O)c2c(-c3nccn3C)n(Cc3c[nH]c4ccc(Cl)cc34)nc21",
        "output": "327"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Clc1nc(Nc2cc[nH]n2)cc2ccccc12.N#Cc1cccc(O)c1>>N#Cc1cccc(Oc2nc(Nc3cc[nH]n3)cc3ccccc23)c1",
        "output": "516"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C1COCCN1.CC(C)(C)[O-].Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1ncnc2c1cnn2-c1ccc(Br)cc1.[K+].[Pd]>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1ncnc2c1cnn2-c1ccc(N2CCOCC2)cc1",
        "output": "294"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc(O)cc1.O.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)Nc1ccc(O)cc1",
        "output": "735"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)COc1cccc(F)c1C=O.CCO.Cl.Cl.NO.O.[Na+].[OH-]>>CC(C)COc1cccc(F)c1C=NO",
        "output": "30"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(C=O)CC1.ClCCl.FC(F)(F)C1CCCNC1.[Na+]>>CC(C)(C)OC(=O)N1CCC(CN2CCCC(C(F)(F)F)C2)CC1",
        "output": "484"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1CCCC(C)N1CC(=O)O.CN(C)C=O.Cl.O=C1CCC(=O)N1O>>CC1CCCC(C)N1CC(=O)ON1C(=O)CCC1=O",
        "output": "303"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N(CCOc1cc(Cl)cc(C(=O)O)c1)c1ccncc1.CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)c1ccncc1.COC(=O)CCNc1ccccc1.ClCCl.O=C(Cl)C(=O)Cl>>COC(=O)CCN(C(=O)c1cc(Cl)cc(OCCN(C(=O)OC(C)(C)C)c2ccncc2)c1)c1ccccc1",
        "output": "873"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCNC(=O)c1noc(-c2cc(C(C)C)c(OCc3ccccc3)cc2OCc2ccccc2)c1-c1noc(CO)n1.CS(=O)(=O)Cl>>CCNC(=O)c1noc(-c2cc(C(C)C)c(OCc3ccccc3)cc2OCc2ccccc2)c1-c1noc(COS(C)(=O)=O)n1",
        "output": "0"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.Cc1nc2c(O)cccn2c(=O)c1CCO.O=S(Cl)Cl>>Cc1nc2c(O)cccn2c(=O)c1CCCl",
        "output": "96"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Fc1ccc(Br)cn1.OCCCN1CCC1.[H-].[Na+]>>Brc1ccc(OCCCN2CCC2)nc1",
        "output": "541"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CCN(CC(=O)N1CCc2cc(O)ccc21)C(=O)OC(C)(C)C.CN(C)C=O.COc1cc(CCl)ccc1CC(C)C.O.O=C([O-])[O-].[K+].[K+]>>COc1cc(COc2ccc3c(c2)CCN3C(=O)CN(CCC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)ccc1CC(C)C",
        "output": "49"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=CCC(Oc1ccc(CCC(=O)O)c(C)c1)c1oc(-c2ccc(C(F)(F)F)cc2)nc1C.[Pd]>>CCCC(Oc1ccc(CCC(=O)O)c(C)c1)c1oc(-c2ccc(C(F)(F)F)cc2)nc1C",
        "output": "116"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1(C)CNCCN1.ClCCl.[Cl-].[Na+]>>CC1(C)CN(C(=O)OC(C)(C)C)CCN1",
        "output": "694"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCO.CN1CCNCC1.Cc1ccccc1-c1cc(Cl)[n+]([O-])cc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>Cc1ccccc1-c1cc(N2CCN(C)CC2)[n+]([O-])cc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClCCl.NCCc1ccccc1.O>>CC(=O)NCCc1ccccc1",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)Cl.Cl.NCCCCCC(=O)O.O.[Na+].[OH-]>>CS(=O)(=O)NCCCCCC(=O)O",
        "output": "493"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)CCN(Cc1ccc(Cl)cc1)C1CCN(C(=O)OC(C)(C)C)C1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)CCN(Cc1ccc(Cl)cc1)C1CCNC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CN(C)C=O.COc1ccc(Br)c(OC)c1C(=O)O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(Br)c(OC)c1C(=O)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=CCBr.CC(C)=O.O=C([O-])[O-].Oc1cc(Nc2ccccn2)ccc1Cl.[Cs+].[Cs+]>>CC(C)=CCOc1cc(Nc2ccccn2)ccc1Cl",
        "output": "77"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CS(=O)(=O)OCCC(c1ccccc1)c1ccccc1.O=C([O-])[O-].[K+].[K+].c1ccc(CN2CCCNCC2)cc1>>c1ccc(CN2CCCN(CCC(c3ccccc3)c3ccccc3)CC2)cc1",
        "output": "496"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(-n2nc3c4cccc(F)c4[nH]cc-3c2=O)cc1>>O=C(Cl)c1ccc(-n2nc3c4cccc(F)c4[nH]cc-3c2=O)cc1",
        "output": "448"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1cnc(Cl)c2ccc(SCc3ccccc3)cc12.ClCCl>>Oc1cnc(Cl)c2ccc(SCc3ccccc3)cc12",
        "output": "424"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CI.COCC1C(=O)OC1CCCCC(C)CC(C)O.O=[Ag]>>COCC1C(=O)OC1CCCCC(C)CC(C)OC",
        "output": "140"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(C)(C)C.COc1ccc(C(=O)Cl)cc1.O.c1ccc(NCCc2ccccn2)cc1.c1ccncc1>>COc1ccc(C(=O)N(CCc2ccccn2)c2ccccc2)cc1",
        "output": "614"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)Cn1c(CC(C)O)nc2cnc3ccccc3c21.CI.CN(C)C=O.[H-].[Na+]>>COC(C)Cc1nc2cnc3ccccc3c2n1CC(C)C",
        "output": "140"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "OC(CCCl)c1cccc(Cl)c1.[I-].[Na+]>>OC(CCI)c1cccc(Cl)c1",
        "output": "97"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCC1CNCCO1.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(C(C)C)C(C)C.CN(C)C=O.Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)O)n1>>Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCOC(CCNC(=O)OC(C)(C)C)C2)n1",
        "output": "811"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.CCN(CC)CC.Cc1ncc2n1C(=O)N(C1CCN(C(=O)[C@H](N)CS(=O)(=O)c3ccc4cc(Cl)ccc4c3)CC1)C2.Cl.Cl.ClCCl.O=C([O-])O.[Na+]>>CC(=O)N[C@H](CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)C(=O)N1CCC(N2Cc3cnc(C)n3C2=O)CC1",
        "output": "159"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)N1CCC(N)CC1.Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)O)cn1>>Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)NC2CCN(C(C)C)CC2)cn1",
        "output": "674"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.Cc1ccc(C(O)c2cc(OCc3ccccc3)c3nc[nH]c(=O)c3c2)cc1.ClCCl>>Cc1ccc(C(O)c2cc(O)c3nc[nH]c(=O)c3c2)cc1",
        "output": "264"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCN(C(C)C)C(C)C.ClCCl.Nc1ccncc1F.O=C(Cl)c1c(Cl)cccc1Cl>>O=C(Nc1ccncc1F)c1c(Cl)cccc1Cl",
        "output": "11"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.C[O-].Fc1ccc(F)c(NCC2CCOCC2)n1.[Na+]>>COc1ccc(F)c(NCC2CCOCC2)n1",
        "output": "541"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.Cl.NCc1cc2c(-c3ccc(S(=O)(=O)N4CCCC4)cc3)ccnc2n1S(=O)(=O)c1ccccc1.O.[Na+].[OH-]>>NCc1cc2c(-c3ccc(S(=O)(=O)N4CCCC4)cc3)ccnc2[nH]1",
        "output": "831"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.ClCCl.O.O=Cc1cccc2[nH]ccc12.O=S(=O)(Cl)c1ccccc1.O=S(=O)([O-])O.[Na+].[OH-]>>O=Cc1cccc2c1ccn2S(=O)(=O)c1ccccc1",
        "output": "648"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "NC(=O)[C@@H](N)CC1CC1.O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1>>NC(=O)[C@H](CC1CC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1",
        "output": "738"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC[SiH](CC)CC.Cc1ccccc1C1CC(O)c2cc(Br)ccc2O1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccccc1C1CCc2cc(Br)ccc2O1",
        "output": "447"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)CCN.COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC.ClCCCl.ClCCl.On1nnc2ccccc21>>COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN(C)C)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C(=O)O)S(C)(=O)=O.CCN(CC)CC.CN(C)C=O.Cl.Cl.NCCn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)c(Cl)c3)c21.O.O=S(Cl)Cl>>CC(C)(C(=O)NCCn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)c(Cl)c3)c21)S(C)(=O)=O",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)CCCCCCC(CCCC(O)COc1ccc(F)cc1)C(C)=O.CO.O.[Na+].[OH-]>>CC(=O)C(CCCCCCC(=O)O)CCCC(O)COc1ccc(F)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CNc1ccc([N+](=O)[O-])cc1.ClCCl.O=S(=O)(Cl)c1cccc(-c2ccc(F)cc2)c1.c1ccncc1>>CN(c1ccc([N+](=O)[O-])cc1)S(=O)(=O)c1cccc(-c2ccc(F)cc2)c1",
        "output": "791"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCn1c(CN(C)C(=O)OCc2ccccc2)cc2ccccc21.CO.[OH-].[OH-].[Pd+2]>>CCn1c(CNC)cc2ccccc21",
        "output": "428"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CC#N.ClCCl.O=[N+]([O-])c1ccc(F)c(F)c1>>O=[N+]([O-])c1ccc(N2CCCCC2)c(F)c1",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C[C@H]1CN(c2ccc3ccccc3n2)CCN1.O=C(NCc1ccc(F)cc1)C1(CCCCBr)c2ccccc2-c2ccccc21>>C[C@H]1CN(c2ccc3ccccc3n2)CCN1CCCCC1(C(=O)NCc2ccc(F)cc2)c2ccccc2-c2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F.O=S(=O)(Cl)C1CC1c1ccccc1>>O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)C1CC1c1ccccc1",
        "output": "194"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)Oc1cccc(CCO)c1.ClC(Cl)Cl>>CC(C)Oc1cccc(CC=O)c1",
        "output": "142"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(C(=O)N(C)C2CN(C(=O)C3CCNCC3)CC2c2ccc(Cl)cc2)cc1C(F)(F)F.CSCCC=O>>COc1ccc(C(=O)N(C)C2CN(C(=O)C3CCN(CCCSC)CC3)CC2c2ccc(Cl)cc2)cc1C(F)(F)F",
        "output": "484"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.N#Cc1ccccc1O>>N#Cc1ccccc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(SC2CC(=O)N2CC(=O)O)cc1.NCc1ccccc1>>COc1ccc(SC2CC(=O)N2CC(=O)NCc2ccccc2)cc1",
        "output": "599"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)c1cc(Cc2ccc(F)cc2)c(Cl)cn1.Cl.[Na+].[OH-]>>O=C(O)c1cc(Cc2ccc(F)cc2)c(Cl)cn1",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[O-].CN(C)C=O.Cl.NC(=O)c1nccc(Cl)c1Cl.Nc1ccc(O)cc1.[K+]>>NC(=O)c1nccc(Oc2ccc(N)cc2)c1Cl",
        "output": "351"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cc1ccc([N+](=O)[O-])cc1O.O.O=[N+]([O-])c1ccc(OCc2ccccn2)cc1.[Cl-].[NH4+]>>Nc1ccc(OCc2ccccn2)cc1",
        "output": "202"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(=O)CC1CCC(C)CN1.ClCCl>>CCOC(=O)CC1CCC(C)CN1C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCc1noc(C)c1COc1ccc(C(=O)OC)cn1.NC(CO)CO>>CCCCc1noc(C)c1COc1ccc(C(=O)NC(CO)CO)cn1",
        "output": "862"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CCn1nc(-c2ccc(OCc3ccccc3)cc2)c2nccnc21.CO.[Pd]>>CCn1nc(-c2ccc(O)cc2)c2nccnc21",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)CNN.CC(C)C[C@@H](C(=O)O)[C@H](C/C=C/c1ccccc1)C(=O)OC(C)(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.COC(C)(C)C.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccc(S(=O)(=O)O)cc1.Cl.Cl.O.Oc1cccc2[nH]nnc12>>CC(C)CNNC(=O)[C@H](CC(C)C)[C@H](C/C=C/c1ccccc1)C(=O)OC(C)(C)C",
        "output": "459"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)NCCN.COC(=O)c1ncc2c(cc(-c3ccccc3)c(=O)n2Cc2ccccc2)c1O>>CC(C)(C)OC(=O)NCCNC(=O)c1ncc2c(cc(-c3ccccc3)c(=O)n2Cc2ccccc2)c1O",
        "output": "487"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CS(C)=O.N#C[C@@H]1CCCN1C(=O)CCl.NC12CC3CC1CC(c1ccc(N4CCCS4(=O)=O)cc1)(C3)C2.O=C([O-])[O-].[K+].[K+]>>N#C[C@@H]1CCCN1C(=O)CNC12CC3CC1CC(c1ccc(N4CCCS4(=O)=O)cc1)(C3)C2",
        "output": "330"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.Cc1cc(C(=O)O)cc(Cl)n1.O=S(=O)(O)O>>Cc1cc(C(=O)OC(C)C)cc(Cl)n1",
        "output": "33"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.Cc1ccc(-n2nc(C(C)(CF)CF)cc2N)cc1.O.O=C(Cl)OCC(Cl)(Cl)Cl.O=C([O-])[O-].[Na+].[Na+]>>Cc1ccc(-n2nc(C(C)(CF)CF)cc2NC(=O)OCC(Cl)(Cl)Cl)cc1",
        "output": "700"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCn1c2nc[nH]c2c(=O)n2c(CCNC(=O)OCc3ccccc3)nnc12.CO.[Pd]>>CCCCCn1c2nc[nH]c2c(=O)n2c(CCN)nnc12",
        "output": "574"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(CC1(O)CC1)OC.CS(=O)(=O)Cl.ClCCl>>COC(CC1(OS(C)(=O)=O)CC1)OC",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1ncccc1OC[C@H]1CCCN1.COc1cnc(C(=O)O)c(OC[C@H]2CCCN2C(=O)[C@H]2CC[C@H](C(F)(F)F)CC2)c1.O=C(O)c1cccc(C(F)(F)F)c1>>CCOC(=O)c1ncccc1OC[C@H]1CCCN1C(=O)c1cccc(C(F)(F)F)c1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1ccc(O)cc1.CN(C)C=O.Cl.N#Cc1cccc(F)c1.O=C([O-])[O-].[Cs+].[Cs+]>>CCCc1ccc(Oc2cccc(C#N)c2)cc1",
        "output": "564"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cc(Cl)c(C)s1.[Na+].[OH-]>>Cc1sc(C(=O)O)cc1Cl",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCc1c(C(=O)OC)ccn(C2CCN(Cc3cc(C4CC4)c(C4CC4)c(F)c3OC(C)C)CC2)c1=O.[Na+].[OH-]>>CCc1c(C(=O)O)ccn(C2CCN(Cc3cc(C4CC4)c(C4CC4)c(F)c3OC(C)C)CC2)c1=O",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)O.CC(Cl)C(=O)Cl.CCN(CC)CC.NC(CO)CCO>>CC(Cl)C(=O)NC(CO)CCO",
        "output": "45"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)c1cc(-n2cnnn2)cc(-n2ccc(C)cc2=O)c1.O.O.[Li]O>>Cc1ccn(-c2cc(C(=O)O)cc(-n3cnnn3)c2)c(=O)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CN(C)C=O.NCc1ccc(Cl)cc1.O=C(O)c1cnc2sc(I)cc2c1O.O=C(n1ccnc1)n1ccnc1>>O=C(NCc1ccc(Cl)cc1)c1cnc2sc(I)cc2c1O",
        "output": "790"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCOc1ccc2c(=O)c(C)c(-c3ccccc3)oc2c1C(C)=O.CCO.O.O=Cc1ccccc1.[K+].[OH-]>>C=CCOc1ccc2c(=O)c(C)c(-c3ccccc3)oc2c1C(=O)C=Cc1ccccc1",
        "output": "295"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)[C@@H]1C[C@H]1COc1cc(CCCOC)cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@@H]2c2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)C2CC2)c1.CCOC(C)=O.O=C([O-])[C@H](O)[C@@H](O)C(=O)[O-].[H-].[K+].[Na+]>>COCCCc1cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@@H]2c2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)C2CC2)cc(OC[C@@H]2C[C@H]2CO)c1",
        "output": "225"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccccc1C1CCN(C(=O)c2c[nH]c3cc(Cl)ccc23)CC1.NCCCl>>COc1ccccc1C1CCN(C(=O)c2cn(CCN)c3cc(Cl)ccc23)CC1",
        "output": "42"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CCO.Cc1cc(C(=O)N2C[C@H](C)N[C@H](C)C2)c(C=O)[nH]1.O=C1Cc2c(cccc2-c2ccccc2F)N1>>Cc1cc(C(=O)N2C[C@H](C)N[C@H](C)C2)c(C=C2C(=O)Nc3cccc(-c4ccccc4F)c32)[nH]1",
        "output": "440"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCOCC.ClCCl.FB(F)F.O.Oc1ccccc1O>>CC(=O)c1cccc(O)c1O",
        "output": "435"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)CCc1c[nH]c2c(-c3noc(-c4ccc(OCC)c(OCC)c4)n3)cccc12.CO.O.[Na+].[OH-]>>CCOc1ccc(-c2nc(-c3cccc4c(CCC(=O)O)c[nH]c34)no2)cc1OCC",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)N(NC(=O)c1ccccc1)C(=O)COc1ccc(F)cc1Br.CCOc1ccccc1B(O)O.COCCOC.O=C([O-])[O-].[Na+].[Na+]>>CCOc1ccccc1-c1cc(F)ccc1OCC(=O)N(NC(=O)c1ccccc1)C(C)C",
        "output": "837"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)CCCBr.CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1>>CC(C)CCCN1CCN(c2ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1CCNCC1.Cc1cc(N(Cc2ccccc2)Cc2ccccc2)c(F)cc1Br.Cc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Cc1cc(N(Cc2ccccc2)Cc2ccccc2)c(F)cc1N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "294"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.Cc1cc(Cl)ncc1[N+](=O)[O-].NCCN>>Cc1cc(NCCN)ncc1[N+](=O)[O-]",
        "output": "70"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(C(=O)O)c(C)c1.Cl.NCC(=O)NC(c1ccccc1)c1ccc(Cl)cc1>>COc1ccc(C(=O)NCC(=O)NC(c2ccccc2)c2ccc(Cl)cc2)c(C)c1",
        "output": "718"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)[O-].O.O=C1CSC(=O)N1.O=Cc1ccccc1[N+](=O)[O-].[Na+]>>O=C1NC(=O)C(=Cc2ccccc2[N+](=O)[O-])S1",
        "output": "761"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNc1cc(-n2ncnc2Nc2cc(C(=O)O)ccc2C)ncn1.F[P-](F)(F)(F)(F)F.Nc1cccc(C(F)(F)F)c1>>CNc1cc(-n2ncnc2Nc2cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc2C)ncn1",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](O)C1.CC(C)(C)[O-].N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1F.[K+]>>CC(C)(C)OC(=O)N1CC[C@@H](Oc2ccc(-c3ncnc(Nc4ccc(N5CCN(C6COC6)CC5)cc4)n3)cc2C#N)C1",
        "output": "485"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CNC(=O)CC(c1ccccc1)c1cccc2cn[nH]c12.CNCCC(c1ccccc1)c1cccc2cc[nH]c12.O=C(O)C(F)(F)F>>CNCCC(c1ccccc1)c1cccc2cn[nH]c12",
        "output": "112"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.COc1c(C(=O)NC2CCN(C(=O)COC(C)=O)CC2)n(C)c2c1c(=O)n(CC(=O)c1ccccc1)c1ccccc21.Cl.O.[Na+].[OH-]>>COc1c(C(=O)NC2CCN(C(=O)CO)CC2)n(C)c2c1c(=O)n(CC(=O)c1ccccc1)c1ccccc21",
        "output": "687"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.Cc1cc2c(cc1-c1ccc(N)nc1)CCO2.ClCCl.ClCCl.O=C(Cl)c1c(F)cccc1F.O=C([O-])O.[Na+]>>Cc1cc2c(cc1-c1ccc(NC(=O)c3c(F)cccc3F)nc1)CCO2",
        "output": "463"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)C1CN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)C1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OCC1CN(Cc2ccc(C(F)(F)F)cc2C(F)(F)F)C1",
        "output": "343"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COc1cc(OC)c(Cl)c(NC(C)=O)c1F.O.[K+].[OH-]>>COc1cc(OC)c(Cl)c(N)c1F",
        "output": "66"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CO.NC(Cc1ccccc1)c1cc(Br)cs1.[Na+].[OH-]>>CC(C)(C)OC(=O)NC(Cc1ccccc1)c1cc(Br)cs1",
        "output": "631"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1cc(COc2ccccc2)nn1CCNC(=O)OC(C)(C)C.CCOC(C)=O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(C)OC(=O)NCCn1nc(COc2ccccc2)cc1CO",
        "output": "391"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.O=C(O)Cc1ccc(Cl)nc1.O=S(Cl)Cl>>COC(=O)Cc1ccc(Cl)nc1",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCc1nc2cnc3ccccc3c2n1CC1(O)CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O.O=C(O)C(F)(F)F.[Na+].[OH-]>>CCOCc1nc2cnc3ccccc3c2n1CC1(O)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COc1ccc([N+](=O)[O-])cc1OCCN1CCCCC1.Cl.O.[Cl-].[Fe].[NH4+]>>COc1ccc(N)cc1OCCN1CCCCC1",
        "output": "202"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc2nc(Oc3ccccc3)ccc2c1.c1ccncc1>>O=S(=O)(Oc1ccc2nc(Oc3ccccc3)ccc2c1)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)[C@@H](N)CC(C)C.CN(C)C=O.COc1ccc(CC(Sc2ccccc2Br)C(=O)O)cc1.Cl.Cl.On1nnc2ccccc21>>CCOC(=O)[C@H](CC(C)C)NC(=O)C(Cc1ccc(OC)cc1)Sc1ccccc1Br",
        "output": "107"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)CCCOc1c(CNc2ccc(C(C)=O)cc2)cccc1OC.CO.O.O=C([O-])[O-].[K+].[K+]>>COc1cccc(CNc2ccc(C(C)=O)cc2)c1OCCCC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Nc1cccc2c1CC(O)CC2.CC(=O)OC(C)=O.c1ccncc1>>CC(=O)Nc1cccc2c1CC(OC(C)=O)CC2",
        "output": "254"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Brc1ccc2c(c1)CC1(CC2)OCCO1.C#C[Si](C)(C)C.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.[Pd+2]>>C[Si](C)(C)C#Cc1ccc2c(c1)CC1(CC2)OCCO1",
        "output": "671"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)c1sc(-c2cn(CC(F)(F)c3ccccc3)nn2)nc1C.O.O.[Li+].[OH-]>>Cc1nc(-c2cn(CC(F)(F)c3ccccc3)nn2)sc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C(=CC1CCOCC1)c1ccc(SC2CC2)cc1.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)C(=CC1CCOCC1)c1ccc(S(=O)C2CC2)cc1",
        "output": "500"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[Si](C)(C)c1cc([N+](=O)[O-])cc([Si](C)(C)C)c1.[Pd].c1ccccc1>>C[Si](C)(C)c1cc(N)cc([Si](C)(C)C)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCNCC1.CN1CCOCC1.COc1cc(Br)ccc1C(=O)O.F[P-](F)(F)(F)(F)F>>COc1cc(Br)ccc1C(=O)N1CCN(C)CC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cn(C(CC2(C)CC2)C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N.O=C(O)C(F)(F)F>>COc1cn(C(CC2(C)CC2)C(=O)Nc2ccc(C(=O)O)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N",
        "output": "752"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClC(Cl)Cl.NCC1CCOC1.O.O=C(O)c1cc(COCc2ccc(Cl)cc2)on1.On1nnc2ccccc21>>O=C(NCC1CCOC1)c1cc(COCc2ccc(Cl)cc2)on1",
        "output": "696"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCC(O)C1CCCCC1.CN(C)c1ccncc1.ClCCl.O=C(Cl)c1ccccc1.c1ccncc1>>CC(C)(C)OC(=O)NCC(OC(=O)c1ccccc1)C1CCCCC1",
        "output": "51"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cccc2cc[n+]([O-])cc12.O=P(Cl)(Cl)Cl>>COc1cccc2ccnc(Cl)c12",
        "output": "2"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)Cn1c(C)c(Cc2ccsc2S(=O)(=O)c2ccccc2)c2cc(F)ccc21.Cl.[Na+].[OH-]>>Cc1c(Cc2ccsc2S(=O)(=O)c2ccccc2)c2cc(F)ccc2n1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cc(C(=O)OC)n(Cc2cc(-c3ccc(Cl)s3)on2)n1.Cl.O.[Na+].[OH-]>>COC(=O)c1cc(C(=O)O)n(Cc2cc(-c3ccc(Cl)s3)on2)n1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCOC(=O)c1ccc([C@H](C)n2nc(-c3cc(C(F)(F)F)ccc3F)cc2-c2ccc3cc(OC)ccc3c2)cc1.CO.O.O=C(O)c1ccccc1.[Na+].[OH-]>>COc1ccc2cc(-c3cc(-c4cc(C(F)(F)F)ccc4F)nn3[C@@H](C)c3ccc(C(=O)O)cc3)ccc2c1",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CCO.COC(=O)c1cccc(-c2cccc([N+](=O)[O-])c2)c1.O.[Fe]>>COC(=O)c1cccc(-c2cccc(N)c2)c1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.CSc1nc(Cl)cc(-c2ccc(C(F)(F)F)cc2)n1.[Na]>>COc1cc(-c2ccc(C(F)(F)F)cc2)nc(SC)n1",
        "output": "653"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)c1c[nH]c2ccccc12.COc1ccc(S(=O)(=O)Cl)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1.[H-].[Na+]>>COc1ccc(S(=O)(=O)n2cc(C(C)=O)c3ccccc32)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1",
        "output": "648"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CI.COC(=O)c1ccc(Nc2ncc(F)c(Nc3ccc(C(=O)OC)c(OC)c3)n2)cc1OC.Cc1cc([N+](=O)[O-])cc(C)c1O.O=C([O-])[O-].[K+].[K+]>>COc1c(C)cc([N+](=O)[O-])cc1C",
        "output": "62"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.N#Cc1c(Cl)nc2ccc([N+](=O)[O-])cc2c1Cl>>N#Cc1c(Cl)nc2ccc(N)cc2c1Cl",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cn1c(C(N)=O)cc2cc(F)cc(Br)c21.OB(O)c1ccc(F)cc1>>Cn1c(C(N)=O)cc2cc(F)cc(-c3ccc(F)cc3)c21",
        "output": "833"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1.O=C1CCC(O)(c2ccc(Cl)cc2)CC1>>O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(O)(c3ccc(Cl)cc3)CC2)C1",
        "output": "187"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc(CCO)cc2c1OCO2.Cc1ccccc1.O.O=S(Cl)Cl.c1ccncc1>>COc1cc(CCCl)cc2c1OCO2",
        "output": "96"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1ccc(B(O)O)cc1.Fc1cccc(-c2nc3cnn(Cc4ccc(Cl)nn4)cc-3n2)c1F>>CCc1ccc(-c2ccc(Cn3cc4nc(-c5cccc(F)c5F)nc-4cn3)nn2)cc1",
        "output": "866"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)C=O.Cc1cccc(C)c1N=C=O.Nc1cc2ccccc2cc1C(=O)N(CC(=O)OCc1ccccc1)CC1CCCCC1>>Cc1cccc(C)c1NC(=O)Nc1cc2ccccc2cc1C(=O)N(CC(=O)OCc1ccccc1)CC1CCCCC1",
        "output": "993"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cl.NC(=O)Cn1c(=O)oc2cc(-c3cn(S(=O)(=O)c4ccccc4)c4ccc(F)cc34)ccc21.O.[Na+].[OH-]>>NC(=O)Cn1c(=O)oc2cc(-c3c[nH]c4ccc(F)cc34)ccc21",
        "output": "771"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.Cc1ccc(O)cc1.Cc1ccccc1.Cl.O=S(=O)(Cl)c1ccc(I)cc1>>Cc1ccc(OS(=O)(=O)c2ccc(I)cc2)cc1",
        "output": "380"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC#N.CCN(CC)CC.CN[C@@H]1CC[C@@H](OC(=O)C(O)(c2cccs2)c2cccs2)CC1.COc1cc(OCCCBr)c(Cl)cc1CO>>COc1cc(OCCCN(C)[C@@H]2CC[C@@H](OC(=O)C(O)(c3cccs3)c3cccs3)CC2)c(Cl)cc1CO",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N1CC(C)(C)c2ccc(NC(=O)c3cccnc3Nc3ccc4cn[nH]c4c3)cc21.CCO.Cl>>CC1(C)CNc2cc(NC(=O)c3cccnc3Nc3ccc4cn[nH]c4c3)ccc21",
        "output": "504"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)c1ccncc1.CN1CCNCC1.Cc1ccc2c(c1)c1c(n2CC(=O)O)CCN(C)C1.ClCCl.O=C(Cl)C(=O)Cl>>Cc1ccc2c(c1)c1c(n2CC(=O)N2CCN(C)CC2)CCN(C)C1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)NCc1cccc2c1CCN(C(=O)OC(C)(C)C)C2.ClCCl.O.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)NCc1cccc2c1CCNC2",
        "output": "887"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O=[N+]([O-])c1ccc2c(c1)CCN(C[C@H](O)C(F)(F)F)CC2.[Pd]>>Nc1ccc2c(c1)CCN(C[C@H](O)C(F)(F)F)CC2",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nc1ccc(S(=O)(=O)C(F)(F)F)cc1Cl.O=C(O)c1cc(F)cc(F)c1O>>O=C(Nc1ccc(S(=O)(=O)C(F)(F)F)cc1Cl)c1cc(F)cc(F)c1O",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(OCCO)(c2nccs2)C1.CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCCOC2(c3nccs3)CCN(C(=O)OC(C)(C)C)C2)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br[Mg]c1ccccc1.CC(C)(C)OC(=O)N1CC(Oc2cc(Br)ccc2C=O)C1.ClCCl>>CC(C)(C)OC(=O)N1CC(Oc2cc(Br)ccc2C(O)c2ccccc2)C1",
        "output": "309"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)Cn1c(=O)n(C)c(=O)c2c(SCCCN)c(Cc3cccc4ccccc34)sc21.CN(C)C(=O)Cl>>CC(C)Cn1c(=O)n(C)c(=O)c2c(SCCCNC(=O)N(C)C)c(Cc3cccc4ccccc34)sc21",
        "output": "454"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#Cc1cccc(O)c1.COC(=O)CCc1ccc(I)cc1>>COC(=O)CCc1ccc(C#Cc2cccc(O)c2)cc1",
        "output": "664"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.CCOC(C)=O.ClCCl.O=C(O)C(F)(F)F.O=CC1CC1.Oc1ccc2c(c1)CCNCC2.[Na+]>>Oc1ccc2c(c1)CCN(CC1CC1)CC2",
        "output": "484"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1cc(C(C)=O)cc(OC)c1OC.COc1ccc(C=O)cc1.Cl.[Na+].[OH-]>>COc1ccc(/C=C/C(=O)c2cc(OC)c(OC)c(OC)c2)cc1",
        "output": "656"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[O-].CC(=O)[O-].COC(=O)c1cc(Br)nc2c3ccc(Cl)cc3n(Cc3ccc(OC)cc3)c12.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cn1ncc2cc(B(O)O)ccc21.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd+2]>>COC(=O)c1cc(-c2ccc3c(cnn3C)c2)nc2c3ccc(Cl)cc3n(Cc3ccc(OC)cc3)c12",
        "output": "869"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CCNCC1.COc1cc(Nc2ncnc3[nH]nc(OCCOS(C)(=O)=O)c23)ccc1OCc1ccccn1>>COc1cc(Nc2ncnc3[nH]nc(OCCN4CCN(C)CC4)c23)ccc1OCc1ccccn1",
        "output": "496"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNCC1.CCCNc1cc(Cl)nc(N)[n+]1[O-].CCO.[K+].[OH-]>>CCCNc1cc(N2CCCCC2)nc(N)[n+]1[O-]",
        "output": "162"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)/N=N/C(=O)OCC.O=C1NC(=O)c2ccccc21.OCCCCCc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C1c2ccccc2C(=O)N1CCCCCc1ccccc1",
        "output": "420"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1c[nH]c(-c2nc([C@H]3CCCNC3)no2)c1.Cl.O=C(O)c1ccnc(F)c1>>Cc1c[nH]c(-c2nc([C@H]3CCCN(C(=O)c4ccnc(F)c4)C3)no2)c1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1ccc(NCc2cnn(-c3ccccc3)c2)cc1.O=C(O)C1CCCc2ccccc21>>CC(C)c1ccc(N(Cc2cnn(-c3ccccc3)c2)C(=O)C2CCCc3ccccc32)cc1",
        "output": "315"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1sc2c(c1C)C(C)NCC2.O=C(O)c1cc2ncc(Br)cn2n1>>Cc1sc2c(c1C)C(C)N(C(=O)c1cc3ncc(Br)cn3n1)CC2",
        "output": "663"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCc1ccc(OC(=O)OC)c(C(C)(C)C)c1.C[Si](C)(C)Cl.ClCCl.O=[N+]([O-])[O-].[Al+3].[Cl-].[Cl-].[Cl-].[K+]>>CCc1cc(C(C)(C)C)c(OC(=O)OC)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CCN(C(C)C)C(C)C.ClCCl.Cn1ncnc1-c1ccc(C(=O)O)cc1.F[P-](F)(F)(F)(F)F.N[C@@H](Cc1ccccc1C(F)(F)F)CN1C(=O)c2ccccc2C1=O>>Cn1ncnc1-c1ccc(C(=O)N[C@@H](Cc2ccccc2C(F)(F)F)CN2C(=O)c3ccccc3C2=O)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(CCO)c1ccc(F)cc1.CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)(CC=O)c1ccc(F)cc1",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(-c2cc(C(F)(F)F)nc(-c3cccc(-c4ccc(S(=O)(=O)NC(C)(C)C)s4)c3)n2)ccc1C(F)(F)F.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(-c2cc(C(F)(F)F)nc(-c3cccc(-c4ccc(S(N)(=O)=O)s4)c3)n2)ccc1C(F)(F)F",
        "output": "680"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N(CCO)Cc1cccc(F)c1.CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.OCCNCc1cccc(F)c1>>Cc1ccc(S(=O)(=O)OCCN(Cc2cccc(F)c2)C(=O)OC(C)(C)C)cc1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)/C(=N\\OC1CCCCC1)c1csc(N)n1.O.[Na+].[OH-]>>Nc1nc(/C(=N/OC2CCCCC2)C(=O)O)cs1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CC(=O)O.COc1ccc(S(=O)(=O)Oc2ccc(CCOc3ccc(C=O)cc3)cc2)cc1.Cc1ccccc1.O.O=C1CSC(=O)N1>>COc1ccc(S(=O)(=O)Oc2ccc(CCOc3ccc(C=C4SC(=O)NC4=O)cc3)cc2)cc1",
        "output": "761"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1ccc2nc(NC3CCc4cc(F)ccc43)ccc2c1.O=C(O)C1CC1>>O=C(Nc1ccc2nc(NC3CCc4cc(F)ccc43)ccc2c1)C1CC1",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(Cc1cn2c(F)cccc2n1)[C@H]1CCCc2cccnc21.NCCN1CCCCC1>>CN(Cc1cn2c(NCCN3CCCCC3)cccc2n1)[C@H]1CCCc2cccnc21",
        "output": "810"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)C(C)(N)CC(=O)N1CCOCC1>>CC(N)(CC(=O)N1CCOCC1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCCCCCOc1ccc(C(=O)Oc2ccc(CN(CC(=O)OC(C)(C)C)C(=O)c3ccc([N+](=O)[O-])cc3)cc2)cc1.[Pd]>>CCCCCCCOc1ccc(C(=O)Oc2ccc(CN(CC(=O)OC(C)(C)C)C(=O)c3ccc(N)cc3)cc2)cc1",
        "output": "28"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=CCCNc1ccc(C#N)cc1[N+](=O)[O-].CCO.Cl[Sn]Cl>>C=CCCNc1ccc(C#N)cc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCI.CN(C)C=O.Cc1c(C)c(C=O)c(C)c(C)c1O.Cl.[H-].[Na+]>>CCCOc1c(C)c(C)c(C=O)c(C)c1C",
        "output": "198"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2)c(-c2ccnc(Cl)n2)s1.CC(C)O.N>>CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2)c(-c2ccnc(N)n2)s1",
        "output": "312"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O[Si](C)(C)C(C)(C)C)C(OC)C3)C(C)C(O[Si](C)(C)C(C)(C)C)CC1=O)C(C)CC2OC.F>>CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(OC)C3)C(C)C(O[Si](C)(C)C(C)(C)C)CC1=O)C(C)CC2OC",
        "output": "708"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.CC(=O)NC1CCC(=O)CC1.Nc1nc2c(s1)CC(N)CC2.O>>CC(=O)NC1CCC(=O)C(Br)C1",
        "output": "82"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccccc1NC(=N)Nc1ccc(N)cc1C.Cl.Cl.Cl.N#N.O.O=N[O-].[N-]=[N+]=[N-].[Na+].[Na+].[Na+].[OH-]>>Cc1ccccc1NC(=N)Nc1ccc(N=[N+]=[N-])cc1C",
        "output": "189"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCC2CCCCC2C1.C=C(C)CCl.CCO.O=C([O-])[O-].O=S([O-])S(=O)[O-].Oc1ccccc1O.[Na+].[Na+].[Na+].[Na+]>>C=C(C)COc1ccccc1O",
        "output": "119"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCc1nc(C)n(Cc2occc2C#N)c(=O)c1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.CO.[Na+].[OH-]>>CCCCc1nc(C)n(Cc2occc2C#N)c(=O)c1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1",
        "output": "815"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)N1CCc2cc(N)ccc21.CCN(CC)CC.CCOC(C)=O.O.O=C(Cl)c1ccccc1-c1ccc(C(F)(F)F)cc1>>CC(=O)N1CCc2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc21",
        "output": "11"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCC(N(C)C(=O)c2ccc(Nc3nc4c(N5CCC(CC(=O)O)(c6ccc(Cl)cc6)CC5)cccn4n3)cc2)CC1.CNC.Cl.F[P-](F)(F)(F)(F)F>>CN1CCC(N(C)C(=O)c2ccc(Nc3nc4c(N5CCC(CC(=O)N(C)C)(c6ccc(Cl)cc6)CC5)cccn4n3)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(=O)CCNC(=O)c1ccc(-c2cc(F)ccc2CNc2ccc(Br)c(F)c2)cn1.CCOC(C)=O.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccc(Cl)c(Cl)c1.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)CCNC(=O)c1ccc(-c2cc(F)ccc2CNc2ccc(-c3ccc(Cl)c(Cl)c3)c(F)c2)cn1",
        "output": "837"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCI.CN(C)C=O.O.O=C([O-])[O-].O=Cc1cccc(O)c1O.[K+].[K+]>>CCCOc1c(O)cccc1C=O",
        "output": "198"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.O.O=C1C=CC(=O)c2c1c(Cl)c1cccc(O)c1c2O.c1ccncc1>>CC(=O)Oc1cccc2c(Cl)c3c(c(O)c12)C(=O)C=CC3=O",
        "output": "46"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(CC(N)=O)CC(=O)OC(C)(C)C.CCOC(C)=O.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CC(C)(CC#N)CC(=O)OC(C)(C)C",
        "output": "172"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#Cc1cnn2c(C(F)F)cc(-c3cccc(C(F)(F)F)c3)nc12.O=S(=O)(NC(CO)CO)c1ccc(Br)s1>>O=S(=O)(NC(CO)CO)c1ccc(C#Cc2cnn3c(C(F)F)cc(-c4cccc(C(F)(F)F)c4)nc23)s1",
        "output": "766"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1ccccc1.CC(C)=O.CCOC(=O)Cc1ccc(O)c(O)c1.Cl.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)Cc1ccc(O)c(OCc2ccccc2)c1",
        "output": "127"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(c1ccccc1-c1ccccc1)C(C)(C)C.CCOC(=O)c1cc2ccc(O)cc2[nH]1.CCOC(C)=O.Cc1ccc(Cn2c(-c3cccc(Br)c3)cc(C(F)(F)F)c(C#N)c2=O)c(C)c1.Cc1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd+2]>>CCOC(=O)c1cc2ccc(Oc3cccc(-c4cc(C(F)(F)F)c(C#N)c(=O)n4Cc4ccc(C)cc4C)c3)cc2[nH]1",
        "output": "238"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.Nc1ncc(Cl)cc1F.OO>>Nc1c(F)cc(Cl)c[n+]1[O-]",
        "output": "396"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.[N-]=[N+]=NCc1cc(O)ccc1S(=O)(=O)Nc1ccc2c(c1)B(O)OC2.[Pd]>>NCc1cc(O)ccc1S(=O)(=O)Nc1ccc2c(c1)B(O)OC2",
        "output": "562"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2ccc(-n3ccnc3)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>c1cn(-c2ccc(C3CCNCC3)cc2)cn1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)Cc1ccc(CC(=O)Cl)cc1.CCN(CC)CC.COCCO>>COCCOC(=O)Cc1ccc(CC(C)C)cc1",
        "output": "126"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CCOC(C)=O.O.O=Cc1ccc(O)cc1O.OCc1cccc(-c2ccc3c(c2)OCCO3)c1Cl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=Cc1ccc(OCc2cccc(-c3ccc4c(c3)OCCO4)c2Cl)cc1O",
        "output": "347"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(CC)CC.CNC.Cl.N#Cc1cnn(-c2ncc(C(F)(F)F)cc2Cl)c1C=CC(=O)Cl>>CN(C)C(=O)C=Cc1c(C#N)cnn1-c1ncc(C(F)(F)F)cc1Cl",
        "output": "135"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)c(C)c3)c2cc1OC.Cc1cnc(C(C)N)s1.ClC(Cl)Cl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)NC(C)c4ncc(C)s4)c(C)c3)c2cc1OC",
        "output": "913"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.CC(=O)O.CCO.O=C([O-])O.O=Cc1cc(Br)cs1.[BH3-]C#N.[Na+].[Na+]>>Brc1csc(CN2CCOCC2)c1",
        "output": "792"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Cl.ClCc1ccc2ccccc2n1.O.OCCc1ccc(O)cc1.[K+].[OH-]>>OCCc1ccc(OCc2ccc3ccccc3n2)cc1",
        "output": "616"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cl.O=C(O)C1CNCC(O)C1>>CCOC(=O)C1CNCC(O)C1",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.COc1ncc(C(=O)O)cc1C(F)(F)F.C[Si](C)(C)Cl.[I-].[K+]>>O=C(O)c1cnc(O)c(C(F)(F)F)c1",
        "output": "408"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O=[N+]([O-])c1ccc2c(c1O)Cc1ccccc1-2.[Pd]>>Nc1ccc2c(c1O)Cc1ccccc1-2",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(C)=O.O=C(Cn1ccc([N+](=O)[O-])n1)Nc1cccc(F)c1.[Pd]>>Nc1ccn(CC(=O)Nc2cccc(F)c2)n1",
        "output": "684"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Cl.O=C(O)c1cc(O)cc(Br)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1cc(O)cc(Br)c1",
        "output": "72"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)n1ncc2c([N+](=O)[O-])cccc21.[BH4-].[Na+]>>COC(=O)n1ncc2c(N)cccc21",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N(C(=O)CN2CCCC(c3ccccc3)(c3ccccc3)C2=O)c2ccc(C(F)(F)F)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(CN1CCCC(c2ccccc2)(c2ccccc2)C1=O)N(c1ccc(C(F)(F)F)cc1)C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC(CC)C(N)c1ncnn1Cc1ccc(F)cc1.CCN(CC)CC.ClCCl.O=S(=O)(Cl)c1ccc(Cl)s1>>CCC(CC)C(NS(=O)(=O)c1ccc(Cl)s1)c1ncnn1Cc1ccc(F)cc1",
        "output": "600"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.CC(C)(C=O)n1cnc([N+](=O)[O-])c1>>CC(C)(CN1CCOCC1)n1cnc([N+](=O)[O-])c1",
        "output": "484"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(=O)(=O)c1ccc(F)c(Cl)c1.O=C(O)COc1ccc(F)cc1O>>CS(=O)(=O)c1ccc(Oc2cc(F)ccc2OCC(=O)O)c(Cl)c1",
        "output": "564"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cc(-c2ccc(Cl)c(C)c2)nc(-c2cccc(-c3ccc(S(=O)(=O)NC(C)(C)C)s3)c2)n1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(-c2ccc(Cl)c(C)c2)nc(-c2cccc(-c3ccc(S(N)(=O)=O)s3)c2)n1",
        "output": "680"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=C(O)c1ccncc1.O=C([O-])[O-].O=S(=O)(O)O.[Na+].[Na+]>>COC(=O)c1ccncc1",
        "output": "33"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCn1cc(CCN2Cc3ccccc3C2)c2c(OCc3ccccc3)cc(F)cc21.CO.[Pd]>>CCn1cc(CCN2Cc3ccccc3C2)c2c(O)cc(F)cc21",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.CCN(CC)CC.CNC1CCOCC1.CNC1CCOCC1.Cc1ccccc1.Cl.ClCCl.O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCC(=O)N(CCCCI)CC1.[Cl-].[Na+].[Na+].[OH-]>>CN(CCCCN1CCN(C(=O)/C=C/c2ccc(Cl)c(Cl)c2)CCC1=O)C1CCOCC1",
        "output": "184"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CS(=O)(=O)c1cccc(O)c1.O=C(NCc1ccc(Cl)cc1Cl)c1ccc(F)nc1.[H-].[Na+]>>CS(=O)(=O)c1cccc(Oc2ccc(C(=O)NCc3ccc(Cl)cc3Cl)cn2)c1",
        "output": "727"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br.COc1ccc(C(=O)Nc2nc3ccc(C)cc3s2)cc1.O>>Cc1ccc2nc(NC(=O)c3ccc(O)cc3)sc2c1",
        "output": "786"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)CC(=O)c2c(C(F)(F)F)nn(-c3ccc(C#N)c(N[C@@H]4CC[C@@H](N)CC4)c3)c2C1.CCO.CS(C)=O.OO.[Na+].[OH-]>>CC1(C)CC(=O)c2c(C(F)(F)F)nn(-c3ccc(C(N)=O)c(N[C@@H]4CC[C@@H](N)CC4)c3)c2C1",
        "output": "180"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CN.O=S(=O)(Cl)c1ccc(CCBr)cc1>>CNS(=O)(=O)c1ccc(CCBr)cc1",
        "output": "43"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@@H](Nc2ncnc3[nH]cc(CCO)c23)C1.CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.ClCCl.ClCCl.O>>CC(C)(C)OC(=O)N1CCC[C@@H](Nc2ncnc3[nH]cc(CCOS(C)(=O)=O)c23)C1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(C=O)cc(F)c1O.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-].c1ccncc1>>O=Cc1cc(O)c(O)c(F)c1",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](C(=O)O)C(C)(C)C.CCN(C(C)C)C(C)C.CCOC(=O)C(C#N)=NOC(N(C)C)=[N+](C)C.CN(C)C=O.COc1ccc(C2=NN(C3CCNCC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.Cl.F[B-](F)(F)F.On1nnc2cccnc21>>COc1ccc(C2=NN(C3CCN(C(=O)[C@H](NC(=O)OC(C)(C)C)C(C)(C)C)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN.CS(C)=O.Fc1cc(-c2c[nH]nc2-c2c(F)ccc(N(Cc3ccccc3)Cc3ccccc3)c2F)ccn1.O>>CNc1cc(-c2c[nH]nc2-c2c(F)ccc(N(Cc3ccccc3)Cc3ccccc3)c2F)ccn1",
        "output": "810"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.ClCCl.OCC1(CO)CC1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCC1(CO)CC1",
        "output": "193"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOc1cc(OCC)c2c(C)c(CCCl)c(=O)oc2c1.COc1ccccc1N1CCNCC1>>CCOc1cc(OCC)c2c(C)c(CCN3CCN(c4ccccc4OC)CC3)c(=O)oc2c1",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCI.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].O=C1C(=Cc2ccc3c(c2)OCO3)Oc2cc(O)ccc21.[K+].[K+]>>CCCCCOc1ccc2c(c1)OC(=Cc1ccc3c(c1)OCO3)C2=O",
        "output": "198"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCN(C2CCNCC2)CC1.CN1CCCC1=O.COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1F>>COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1N1CCC(N2CCCCC2)CC1",
        "output": "676"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.Cl.ClCCl.Nc1cc(C(F)(F)F)ccc1N1CCCCCC1.O.O=C(Cl)c1ccncc1>>O=C(Nc1cc(C(F)(F)F)ccc1N1CCCCCC1)c1ccncc1",
        "output": "11"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O.CS(C)=O.Clc1ccc(Br)cn1.Clc1ccnc2ccccc12.O>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(Oc2ccnc3ccccc23)cc1)C(=O)O",
        "output": "351"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNCC1.CC(C)N1CCN(c2ccc(-c3noc(-c4ccc(CCl)cc4)n3)cn2)CC1.CCO.Cl>>CC(C)N1CCN(c2ccc(-c3noc(-c4ccc(CN5CCCCC5)cc4)n3)cn2)CC1",
        "output": "156"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc(OC2CCN(C)CC2)c2c(Cl)ncnc2c1.Nc1ccc2[nH]cc(Cl)c2c1>>COc1cc(OC2CCN(C)CC2)c2c(Nc3ccc4[nH]cc(Cl)c4c3)ncnc2c1",
        "output": "161"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CCCN(c2cc3nc(C(C)(C)C)sc3cc2[N+](=O)[O-])C1.CO.[Ni]>>CC1CCCN(c2cc3nc(C(C)(C)C)sc3cc2N)C1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#CCCO.CCN(CC)CC.CCOC(C)=O.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>C#CCCOS(=O)(=O)c1ccc(C)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC=CC=CC(=O)O.CCN(CC)CC.CCOC(=O)Cl.NC1CC1.[Cl-].[Na+]>>C/C=C/C=C/C(=O)NC1CC1",
        "output": "549"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)Oc1ccc(C[C@H](NC(=O)OCc2ccccc2)C(=O)O)cc1.CCN1CCOCC1.CCOC(=O)CNC(=O)[C@@H](N)Cc1ccc(OC(C)(C)C)cc1.CN(C)C=O.Cl.On1nnc2ccccc21>>CCOC(=O)CNC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)OCc1ccccc1",
        "output": "133"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COc1ccc(N(C)c2nc(CC#N)nc3ccccc23)cc1.Cl.ClCCl.[Pd]>>COc1ccc(N(C)c2nc(CCN)nc3ccccc23)cc1",
        "output": "246"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cc1ccc2c(c1)c1c(n2CC(N=[N+]=[N-])c2ccncc2)CN(C)CC1.O.[Cl-].[NH4+].[Zn]>>Cc1ccc2c(c1)c1c(n2CC(N)c2ccncc2)CN(C)CC1",
        "output": "89"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1cccc(I)c1.C1COCCO1.CN(C)CC(=O)O.COC(=O)Cc1cc(O)cc(OC)c1.O=C([O-])[O-].[Cl-].[Cs+].[Cs+].[Cu]I.[NH4+].[NH4+].[OH-]>>COC(=O)Cc1cc(OC)cc(Oc2cccc(Br)c2)c1",
        "output": "382"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.CO.COC(OC)N(C)C>>CN(C)/C=C/C(=O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1",
        "output": "898"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Nc1cccc(C2OCCO2)c1.CC(C)=O.Cc1ccc(S(=O)(=O)[O-])cc1.O.c1cc[nH+]cc1>>CC(=O)Nc1cccc(C=O)c1",
        "output": "655"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)CC(C)C.Nc1ccc(-c2ccc(C(F)(F)F)cc2)cc1O.O.O=C(Cl)CCl.O=C([O-])O.[Na+]>>O=C(CCl)Nc1ccc(-c2ccc(C(F)(F)F)cc2)cc1O",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCc1ccccc1N1CCc2c(Cl)nc3c(OC(F)(F)F)cccc3c21.NCCO>>CCc1ccccc1N1CCc2c(NCCO)nc3c(OC(F)(F)F)cccc3c21",
        "output": "70"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO[C@@H](Cc1ccc(O)cc1OC)C(=O)OC.Cc1oc(C(C)(C)C)nc1CCl.O=C([O-])[O-].[Cs+].[Cs+].[I-].[K+]>>CCO[C@@H](Cc1ccc(OCc2nc(C(C)(C)C)oc2C)cc1OC)C(=O)OC",
        "output": "760"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C1Nc2ccc(OCCCCSc3ccc(C4CCCCC4)cc3)cc2CO1.OO>>O=C1Nc2ccc(OCCCCS(=O)c3ccc(C4CCCCC4)cc3)cc2CO1",
        "output": "199"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1c2c(C(=O)O)nc(C(F)(F)F)n2CCN1C(=O)OC(C)(C)C.CI.CN(C)C=O.O=C([O-])O.[Na+]>>COC(=O)c1nc(C(F)(F)F)n2c1C(C)N(C(=O)OC(C)(C)C)CC2",
        "output": "415"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)c1nc(-c2cncs2)c2c(cc(-c3ccccc3)c(=O)n2Cc2ccccc2)c1O.C[O-].NCCC(=O)O.O=C([O-])O.[Na+].[Na+]>>O=C(O)CCNC(=O)c1nc(-c2cncs2)c2c(cc(-c3ccccc3)c(=O)n2Cc2ccccc2)c1O",
        "output": "487"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)NCCC=O.CC(C)C(N)c1nc2nccnc2c(=O)n1Cc1ccccc1.ClCCl.[Na+]>>CC(C)C(NCCCNC(=O)OC(C)(C)C)c1nc2nccnc2c(=O)n1Cc1ccccc1",
        "output": "426"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClCCl.Nc1cccc([N+](=O)[O-])c1>>CC(=O)Nc1cccc([N+](=O)[O-])c1",
        "output": "9"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN1CCN(c2ccc3c(c2)ncn3-c2ccnc(SC)n2)C1=O.CO.ClCCl.O.O=S([O-])OO.[K+]>>CCN1CCN(c2ccc3c(c2)ncn3-c2ccnc(S(C)(=O)=O)n2)C1=O",
        "output": "840"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCc1nn2c(-c3c(OC)cc(COC)cc3OC)cccc2c1[N+](=O)[O-].CO.[C].[Pd]>>CCc1nn2c(-c3c(OC)cc(COC)cc3OC)cccc2c1N",
        "output": "628"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Cc1[nH]c2ccccc2c1CC(=O)O.Nc1ncc([N+](=O)[O-])s1.O=C(n1ccnc1)n1ccnc1>>Cc1[nH]c2ccccc2c1CC(=O)Nc1ncc([N+](=O)[O-])s1",
        "output": "681"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)NC(=O)[C@H]1CN(Cc2ccccc2)C[C@H]1Cc1ccccc1>>CC(C)NC[C@H]1CN(Cc2ccccc2)C[C@H]1Cc1ccccc1",
        "output": "112"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OC(=O)Nc2ccc(OCCCCSc3ccc(Cl)c(Cl)c3)cc21.OO>>CC1(C)OC(=O)Nc2ccc(OCCCCS(=O)c3ccc(Cl)c(Cl)c3)cc21",
        "output": "199"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)Cc1c(Cl)nc(C)nc1Cl.ClCCl.Nc1ccccc1>>COC(=O)Cc1c(Cl)nc(C)nc1Nc1ccccc1",
        "output": "161"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.Cc1ccc(C(=O)c2ccccc2)c(N)c1.O=Cc1ccccc1.O=S(=O)(O)O.[BH4-].[Na+]>>Cc1ccc(C(=O)c2ccccc2)c(NCc2ccccc2)c1",
        "output": "359"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CC(C)OC(=O)N=NC(=O)[O-].CCO.Cc1ccccc1.Nc1ccc(C(=O)O)cc1N.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1ccc(N)c(N)c1",
        "output": "33"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)c1cc(N)n(C2CCCCC2)n1.CCN(C(C)C)C(C)C.Cl.O=C(Cl)Oc1ccccc1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)c1cc(NC(=O)Oc2ccccc2)n(C2CCCCC2)n1",
        "output": "700"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=C(Nc1ccc(Cl)cc1)C1CN(C(=O)c2cccc(-c3ccco3)c2)CCN1C(=O)OCc1ccccc1.[Pd]>>O=C(Nc1ccc(Cl)cc1)C1CN(C(=O)c2cccc(-c3ccco3)c2)CCN1",
        "output": "568"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.Cc1ccccc1-c1nc2c(C)cccc2cc1C=O.[BH4-].[Na+]>>Cc1ccccc1-c1nc2c(C)cccc2cc1CO",
        "output": "476"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)c1cccs1.CCCCCC.CCOC(C)=O.CO.O=Cc1cccc2ccccc12.[Na+].[OH-]>>O=C(C=Cc1cccc2ccccc12)c1cccs1",
        "output": "295"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CCOC(C)=O.COc1ccccc1CC1CN(C(=O)C(F)(F)F)C1.O.O=S([O-])OO.O=S([O-])S(=O)(=O)[O-].[Br-].[K+].[Na+].[Na+].[Na+]>>COc1ccc(Br)cc1CC1CN(C(=O)C(F)(F)F)C1",
        "output": "784"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.Fc1cccc(COc2ccc(Nc3ncnc4cc(OCCCCl)cc(OC5CCOC5)c34)cc2Cl)c1>>Fc1cccc(COc2ccc(Nc3ncnc4cc(OCCCN5CCCCC5)cc(OC5CCOC5)c34)cc2Cl)c1",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.Cc1ncc(-c2ccc(C(=O)Nc3nc4cc(C=O)ccc4n3CC(C)(C)O)s2)o1.Nc1ccccc1.O=Cc1ccccc1>>Cc1ncc(-c2ccc(C(=O)Nc3nc4cc(CNc5ccccc5)ccc4n3CC(C)(C)O)s2)o1",
        "output": "359"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CN(C)C=O.ClC(Cl)Cl.O=C(Cl)C(=O)Cl.O=C(O)Cc1ccccc1-c1ccccc1>>O=C(Cl)Cc1ccccc1-c1ccccc1",
        "output": "56"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.O.O=C(c1ccc(F)cc1)c1ccc([N+](=O)[O-])cc1.[H-].[Na+].c1c[nH]cn1>>O=C(c1ccc(-n2ccnc2)cc1)c1ccc([N+](=O)[O-])cc1",
        "output": "721"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)C[C@]12CC[C@@H]3[C@H]4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O.O.O=C(Cl)CCc1ccccc1.c1ccccc1.c1ccncc1>>CC(C)C[C@]12CC[C@@H]3[C@H]4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2OC(=O)CCc1ccccc1",
        "output": "126"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CC1CCNCC1.CS(C)=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)nc1.[Na+].[Na+]>>CCOC(=O)CC1CCN(c2ccc([N+](=O)[O-])cn2)CC1",
        "output": "220"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CO.COc1ccc(-c2ccc3c(c2)c2cc(Cl)cnc2n3S(=O)(=O)c2ccccc2)cc1.[F-]>>COc1ccc(-c2ccc3[nH]c4ncc(Cl)cc4c3c2)cc1",
        "output": "831"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cc1ccc(C(N=[N+]=[N-])C2CCCS2)o1.[H][H].[Pd]>>Cc1ccc(C(N)C2CCCS2)o1",
        "output": "89"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.N#CCCCCCc1nc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2)o1.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>Clc1ccc(-c2nc(CCCCCc3nnn[nH]3)oc2-c2ccc(Cl)cc2)cc1",
        "output": "366"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cl.N#CCc1ccc(Oc2ccc3c(c2)S(=O)(=O)NC2CCCN32)cc1.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>O=S1(=O)NC2CCCN2c2ccc(Oc3ccc(Cc4nnn[nH]4)cc3)cc21",
        "output": "366"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.CC(=O)O.O=C(O)c1n[nH]c2cc(F)ccc12>>O=C(O)c1n[nH]c2cc(F)c(Br)cc12",
        "output": "98"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.C[O-].O.O=[N+]([O-])c1cc2c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)ncnc2cc1F.[Na+]>>COc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1[N+](=O)[O-]",
        "output": "636"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.O=[N+]([O-])c1cc(Cl)cc(CO)c1>>O=Cc1cc(Cl)cc([N+](=O)[O-])c1",
        "output": "179"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)CCSc2ccc(C=O)cc21.ClCCl.O=C(OO)c1cccc(Cl)c1>>CC1(C)CCS(=O)c2ccc(C=O)cc21",
        "output": "500"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)/N=N/C(=O)OCC.CN(C)CCCO.Cc1cc(O)ccc1Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(OCCCN(C)C)ccc1Br",
        "output": "478"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)[C@@H]1C[C@@H](S(=O)(=O)CC2CC2)CN1c1cc(C)nn1CC(F)(F)F.[Li+].[OH-]>>Cc1cc(N2C[C@H](S(=O)(=O)CC3CC3)C[C@H]2C(=O)O)n(CC(F)(F)F)n1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cccc2nc(CC)n(Cc3ccc(-c4ccccc4-c4nnn[nH]4)cc3)c12.CO.[Na+].[OH-]>>CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1",
        "output": "5"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccccc1.C[C@@H]1O[C@H](Sc2ccccc2)[C@@H](OCc2ccccc2)[C@H](O)[C@@H]1O.Cc1ccccc1.[Cs+].[F-]>>C[C@@H]1O[C@H](Sc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@@H]1O",
        "output": "464"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)N1CCC(=O)CC1.CN(C)C=O.O=C(N[C@@H]1CCCNC1)c1ccccc1.[N-]=C=O>>CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccccc3)C2)CC1",
        "output": "187"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Br.CCN(CC)CC.CCP(=O)(C#N)CC.COCCOC.Nc1ncc(Br)cc1C(=O)O.[Cl-].[NH4+]>>NC(=O)c1cc(Br)cnc1N",
        "output": "704"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CN(C)C(=O)N1CCC(O)(Cn2cnc3c(-c4ccc(Br)cc4)nsc3c2=O)CC1.NCCN1CCCCC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd]>>CN(C)C(=O)N1CCC(O)(Cn2cnc3c(-c4ccc(NCCN5CCCCC5)cc4)nsc3c2=O)CC1",
        "output": "519"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccccc4)oc4cc(Br)ccc4c3=O)cc2)CCC1.NC1(c2ccc(-c3c(-c4ccccc4)oc4ccc(F)cc4c3=O)cc2)CCC1>>NC1(c2ccc(-c3c(-c4ccccc4)oc4cc(Br)ccc4c3=O)cc2)CCC1",
        "output": "793"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)CC1OB(O)c2cc(Oc3ccnc(Cl)c3)ccc21.Cl.O.[Li+].[OH-]>>O=C(O)CC1OB(O)c2cc(Oc3ccnc(Cl)c3)ccc21",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN.O=Cc1ccccn1>>CCNCc1ccccn1",
        "output": "775"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC(=O)Cl.COC(=O)c1ccnc(N)c1.Cl>>CCCC(=O)Nc1cc(C(=O)OC)ccn1",
        "output": "332"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCOC(=O)Cc1ccc(N2CCc3c(C)nc(Cl)nc32)cc1.COc1ccc(B(O)O)cc1Cl.ClCCl.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)Cc1ccc(N2CCc3c(C)nc(-c4ccc(OC)c(Cl)c4)nc32)cc1",
        "output": "874"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CS(=O)(=O)Oc1ccccc1C1CC(c2csc(C3CC[NH2+]CC3)n2)=NO1.ClCCl.O.O=C(Cl)CCl.[Cl-]>>CS(=O)(=O)Oc1ccccc1C1CC(c2csc(C3CCN(C(=O)CCl)CC3)n2)=NO1",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.ClCC1CO1.O=C([O-])[O-].Oc1cccc(Br)c1.[K+].[K+]>>Brc1cccc(OCC2CO2)c1",
        "output": "15"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=O.Cc1cc(C)cc(CNC2CCCn3c2c(-c2ccccc2)c2cc(C)c(C)cc2c3=O)c1.Cl.[BH4-].[Na+]>>Cc1cc(C)cc(CN(C)C2CCCn3c2c(-c2ccccc2)c2cc(C)c(C)cc2c3=O)c1",
        "output": "69"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C(=O)c1ccccc1N(CC(=O)OC(C)(C)C)C(=O)CN1C(=O)c2ccccc2C1=O)c1ccccc1.O.O=C(O)C(F)(F)F>>CN(C(=O)c1ccccc1N(CC(=O)O)C(=O)CN1C(=O)c2ccccc2C1=O)c1ccccc1",
        "output": "278"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(CC)(c1ccc(O)c(C)c1)c1ccc(C#CC2(O)CCCCC2)c(C)c1.CCOC(=O)CCCCCBr.CN(C)C=O.O=C([O-])[O-].[Cl-].[K+].[K+].[NH4+]>>CCOC(=O)CCCCCOc1ccc(C(CC)(CC)c2ccc(C#CC3(O)CCCCC3)c(C)c2)cc1C",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)n(CCCN2C(=O)c3ccccc3C2=O)c1=O.NN.O>>Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)n(CCCN)c1=O",
        "output": "242"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)c1ccc([C@@H]2C[C@H]2C(=O)O)cc1.CC(C)C[C@@H]1NC[C@H](C2CCCCC2)NC1=O.CC(C)C[C@H]1CN(C(=O)[C@@H]2C[C@H]2c2ccccc2)[C@@H](CC(C)C)C(=O)N1>>CC(C)C[C@H]1C(=O)N[C@@H](C2CCCCC2)CN1C(=O)[C@@H]1C[C@H]1c1ccc(C(C)(C)C)cc1",
        "output": "297"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(O)c1cc2nc(Cl)nc(N3CCOCC3)c2s1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(OS(C)(=O)=O)c1cc2nc(Cl)nc(N3CCOCC3)c2s1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)c1cc2ccccc2n1Cc1ccc(F)cc1.[Na+].[OH-]>>O=C(O)c1cc2ccccc2n1Cc1ccc(F)cc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCc1cc(CCCCl)cc2c1NC(=O)CC2(C)C.Cl.O=C([O-])[O-].[K+].[K+].c1ccc2c(N3CCNCC3)nsc2c1>>CCc1cc(CCCN2CCN(c3nsc4ccccc34)CC2)cc2c1NC(=O)CC2(C)C",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.BrCCc1ccccn1.c1ccc2[nH]ccc2c1>>c1ccc(CCn2ccc3ccccc32)nc1",
        "output": "470"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.O=C(O)[C@H]1CC12CCOCC2.O=C(n1ccnc1)n1ccnc1.[NH4+].[OH-]>>NC(=O)[C@H]1CC12CCOCC2",
        "output": "313"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(O)c1ccc(C(=O)Nc2cc(N3CCC[C@H](C(=O)O)C3)n3nccc3n2)cc1.CCN=C=NCCCN(C)C.CN.CN(C)C=O.On1nnc2ccccc21>>CNC(=O)[C@H]1CCCN(c2cc(NC(=O)c3ccc(C(C)(C)O)cc3)nc3ccnn23)C1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=[Cr](=O)([O-])Cl.OCCCc1ccc(C(F)(F)F)cc1.c1cc[nH+]cc1>>O=CCCc1ccc(C(F)(F)F)cc1",
        "output": "142"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CN(C)c1ccncc1.COc1ccc(C(=O)Cl)cc1.ClCCl.Nc1cc(-c2ccc[nH]2)ccc1[N+](=O)[O-].O=C([O-])O.[Na+]>>COc1ccc(C(=O)Nc2cc(-c3ccc[nH]3)ccc2[N+](=O)[O-])cc1",
        "output": "11"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cn1cc(-c2ccc3nnc(Sc4ccc5nc(N)sc5c4)n3c2)cn1.O=C(Cl)C1CC1.c1ccncc1>>Cn1cc(-c2ccc3nnc(Sc4ccc5nc(NC(=O)C6CC6)sc5c4)n3c2)cn1",
        "output": "553"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.C[C@H](N)COc1ccc(Oc2ccc(O)cc2)nc1>>CC(=O)N[C@@H](C)COc1ccc(Oc2ccc(O)cc2)nc1",
        "output": "339"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCl.O=S(=O)(O)Cl.c1ccc2c(c1)CCCC2>>O=S(=O)(Cl)c1ccc2c(c1)CCCC2",
        "output": "182"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN.ClCCl.O=[N+]([O-])c1ccc(Br)nc1>>CNc1ccc([N+](=O)[O-])cn1",
        "output": "715"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(O)C#Cc1cc(Cl)c(N)c2c1OCO2.CN(C)C=O.COc1cc2ncnc(Cl)c2cc1OC.C[Si](C)(C)[N-][Si](C)(C)C.[Cl-].[NH4+].[Na+]>>COc1cc2ncnc(Nc3c(Cl)cc(C#CC(C)(C)O)c4c3OCO4)c2cc1OC",
        "output": "352"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(Cl)ncc1C(=O)O.F[P-](F)(F)(F)(F)F.NC(=O)c1nn(-c2ccc(F)cc2)c2c1CCc1ccc(N)cc1-2.O=C(O)c1cc(Cl)ncc1Cl>>NC(=O)c1nn(-c2ccc(F)cc2)c2c1CCc1ccc(NC(=O)c3cc(Cl)ncc3Cl)cc1-2",
        "output": "50"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOP(=O)(O)c1ccc(Cn2c(=O)c(=O)[nH]c3cc([N+](=O)[O-])ccc32)cc1.Cl.O>>O=c1[nH]c2cc([N+](=O)[O-])ccc2n(Cc2ccc(P(=O)(O)O)cc2)c1=O",
        "output": "618"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C=CCBr.O=C(O)Cc1cccc(O)c1.[H-].[Na+]>>C=CCOc1cccc(CC(=O)O)c1",
        "output": "77"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.N#Cc1ccccc1N1CCN(CC2COc3ccccc3O2)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>NCc1ccccc1N1CCN(CC2COc3ccccc3O2)CC1",
        "output": "175"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1ccc(C#N)cc1.O.O=C([O-])O.[Na+]>>N#Cc1ccc(C(=O)O)cc1",
        "output": "5"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(C)=O.N#Cc1cccc(Br)c1.O.O=C(O)c1ccccn1.O=P([O-])([O-])[O-].O=S1(=O)CCN2C(=N1)C1(c3ccc(O)cc3)CCC2CC1.[Cu]I.[K+].[K+].[K+]>>N#Cc1cccc(Oc2ccc(C34CCC(CC3)N3CCS(=O)(=O)N=C34)cc2)c1",
        "output": "238"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.O.O=S1(=O)CCC(NS(=O)(=O)c2ccc(Br)cc2)C1.[K+].[Pd+2]>>CC1(C)OB(c2ccc(S(=O)(=O)NC3CCS(=O)(=O)C3)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.N#Cc1ccc(NCC(=O)NC2CCCCC2)c([N+](=O)[O-])c1.[C].[Pd]>>N#Cc1ccc(NCC(=O)NC2CCCCC2)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.O=C(Cl)C12CC3CC(CC(C3)C1)C2.OCC(F)(F)Br>>O=C(OCC(F)(F)Br)C12CC3CC(CC(C3)C1)C2",
        "output": "126"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.ClCCl.Cl[Pd]Cl.Nc1cccc(Br)c1.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2cccc(N)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCO.Cc1cc(-c2ccc(CN)cn2)ccn1.Clc1nccc2cc(Br)ccc12>>Cc1cc(-c2ccc(CNc3nccc4cc(Br)ccc34)cn2)ccn1",
        "output": "70"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCc1ccccc1.CC#N.CCC(CC)(c1ccc(Br)cc1)c1ccc(O)c(C)c1.CCOCC.O=C([O-])[O-].[K+].[K+]>>CCC(CC)(c1ccc(Br)cc1)c1ccc(OCc2ccccc2)c(C)c1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOCc1nc2c(N)nc(C)c(C)c2n1CCC1CCNCC1.O=C(Cl)N1CCOCC1>>CCOCc1nc2c(N)nc(C)c(C)c2n1CCC1CCN(C(=O)N2CCOCC2)CC1",
        "output": "258"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN1CCOCC1.CCN=C=NCCCN(C)C.CN1C(=O)CC[C@H]1C(=O)O.Cl.ClCCl.NCc1ccc(F)cc1Cl.On1nnc2ccccc21>>CN1C(=O)CC[C@H]1C(=O)NCc1ccc(F)cc1Cl",
        "output": "797"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCc1ccc(Nc2noc3c(C(=O)OC)c(Cl)ccc23)cc1.O.[Li]O>>CCc1ccc(Nc2noc3c(C(=O)O)c(Cl)ccc23)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CNC(=O)c1ccccc1Nc1nc(Nc2cc([N+](=O)[O-])ccc2C(F)(F)F)ncc1Cl.O.[Cl-].[Fe].[NH4+]>>CNC(=O)c1ccccc1Nc1nc(Nc2cc(N)ccc2C(F)(F)F)ncc1Cl",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NCc1csc(C2CC2)n1.O=C(O)c1ccc(OCC2CC2)c(-c2ccc(Cl)cc2)n1>>O=C(NCc1csc(C2CC2)n1)c1ccc(OCC2CC2)c(-c2ccc(Cl)cc2)n1",
        "output": "137"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)C1CNC1.Cl.Clc1ncccn1>>COC(=O)C1CN(c2ncccn2)C1",
        "output": "36"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N(CCCN1CCCCC1)c1nnc(-c2ccc(N)cc2)o1.CCN(CC)CC.ClCCl.O=C(Cl)c1ccccc1>>CC(C)(C)OC(=O)N(CCCN1CCCCC1)c1nnc(-c2ccc(NC(=O)c3ccccc3)cc2)o1",
        "output": "11"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCc1noc(C)c1/C=C/c1nc(C)c(C(=O)O)s1.NCC1CC1>>CCCCc1noc(C)c1/C=C/c1nc(C)c(C(=O)NCC2CC2)s1",
        "output": "534"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.CC1CN(CC2CCCC2)c2nc(Cl)ncc2N(C)C1=O.COc1cc(C(=O)NC2CCN(C)CC2)ccc1N.Cc1ccc(S(=O)(=O)O)cc1.O>>COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(CC1CCCC1)CC(C)C(=O)N2C",
        "output": "941"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.O=[Mn]=O.OC(c1ccc2ccccc2c1)c1ccc2ccccc2c1>>O=C(c1ccc2ccccc2c1)c1ccc2ccccc2c1",
        "output": "59"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cnc(N2CCNCC2)c(Cl)c1.Cc1cc(N=C=O)c([N+](=O)[O-])cc1C>>CCOC(=O)c1cnc(N2CCN(C(=O)Nc3cc(C)c(C)cc3[N+](=O)[O-])CC2)c(Cl)c1",
        "output": "323"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)N(C)C.Nn1c(=O)c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2sccc21.O=Cc1ccncc1>>O=c1c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2sccc2n1N=Cc1ccncc1",
        "output": "167"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNC1.N#Cc1c[nH]c2ccc(CCNC(=O)c3ccc(-c4ccnc(Cl)n4)cc3)cc12>>N#Cc1c[nH]c2ccc(CCNC(=O)c3ccc(-c4ccnc(N5CCCC5)n4)cc3)cc12",
        "output": "36"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN(C)C=O.COCCBr.O=[N+]([O-])c1ccc(Br)c(O)c1.[I-].[K+]>>COCCOc1cc([N+](=O)[O-])ccc1Br",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cc1ccc([N+](=O)[O-])cc1NC(=O)C=Cc1ccccn1.O.O=C([O-])[O-].[Cl-].[Fe].[K+].[K+].[NH4+]>>Cc1ccc(N)cc1NC(=O)/C=C/c1ccccn1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CN(C)C=O.COC(=O)C1(NC[C@H](O)c2ccnc3ccc(OC)nc23)CCCN(C2CC(c3ccccc3)C2)CC1.COc1ccc2nccc([C@@H](O)CNC3(C(=O)O)CCCNCC3)c2n1.O=C1CC(c2ccccc2)C1.[BH3-]C#N>>COc1ccc2nccc([C@@H](O)CNC3(C(=O)O)CCCN(C4CC(c5ccccc5)C4)CC3)c2n1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCO.CCOC(=O)CC(=O)c1ccc(Cl)c(Cl)c1.Cc1ccc(S(=O)(=O)O)cc1.Cc1cnc(-c2cn[nH]c2N)s1>>Cc1cnc(-c2cnn3c(=O)cc(-c4ccc(Cl)c(Cl)c4)[nH]c23)s1",
        "output": "513"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1ccc(NS(=O)(=O)c2ccccc2N)cc1.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ccncc1>>COc1ccc(NS(=O)(=O)c2ccccc2NC(=O)c2ccncc2)cc1",
        "output": "50"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)[C@@H](N)CCSC.O=C(O)c1ccc(F)cc1-c1ccccc1>>COC(=O)[C@H](CCSC)NC(=O)c1ccc(F)cc1-c1ccccc1",
        "output": "652"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(C)O.CCOC(=O)CCCn1ccc2c(-c3nnc(-c4ccc(OC(C)C)c(Cl)c4)s3)ccnc21.O.[Li+].[OH-]>>CC(C)Oc1ccc(-c2nnc(-c3ccnc4c3ccn4CCCC(=O)O)s2)cc1Cl",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CI.CN(C)C=O.COc1ccc2ncc(C(=O)O)c(Br)c2n1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cnc2ccc(OC)nc2c1Br",
        "output": "415"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.COc1cc(N2CCC(N3CCN(CCF)C(=O)C3)CC2)ccc1[N+](=O)[O-].Cl.Cl[Sn]Cl>>COc1cc(N2CCC(N3CCN(CCF)C(=O)C3)CC2)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COc1ccc(CC(NS(=O)(=O)c2ccccc2)C(=O)NCCCCc2ccccc2)c2ccn(S(=O)(=O)c3ccccc3)c12.[Cl-].[K+].[NH4+].[OH-]>>COc1ccc(CC(NS(=O)(=O)c2ccccc2)C(=O)NCCCCc2ccccc2)c2cc[nH]c12",
        "output": "771"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)COc1ccc(C2C(CCSc3ccc(F)cc3)C(=O)N2c2ccc(F)cc2)cc1.O=CO>>O=C(O)COc1ccc(C2C(CCSc3ccc(F)cc3)C(=O)N2c2ccc(F)cc2)cc1",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC(C(=O)O)n1cc(OC)c(-c2cc(Cl)ccc2C#N)cc1=O.Nc1ccc2c(C(F)(F)F)n[nH]c2c1>>CCC(C(=O)Nc1ccc2c(C(F)(F)F)n[nH]c2c1)n1cc(OC)c(-c2cc(Cl)ccc2C#N)cc1=O",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)CC(CCCCNc2nc(Cl)nc(NCCCCC3CC(C)(C)NC(C)(C)C3)n2)CC(C)(C)N1.CC[O-].Cc1ccccc1.[Na+]>>CCOc1nc(NCCCCC2CC(C)(C)NC(C)(C)C2)nc(NCCCCC2CC(C)(C)NC(C)(C)C2)n1",
        "output": "213"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC(=O)Cl.CCN(CC)CC.CN(C)C=O.COc1ccc2c(O)c(N)cnc2c1.Cl.ClCCl>>CCCC(=O)Nc1cnc2cc(OC)ccc2c1O",
        "output": "422"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)[Si](OCCc1cc(F)cc(F)c1)(C(C)C)C(C)C.CN(C)C=O.[Cl-].[Li]CCCC.[NH4+]>>CC(C)[Si](OCCc1cc(F)c(C=O)c(F)c1)(C(C)C)C(C)C",
        "output": "239"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Clc1nccc2c(Br)cccc12.N>>Nc1nccc2c(Br)cccc12",
        "output": "388"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.Cc1ccccc1.O=C(Cl)c1ccccc1Br.OC1CCN(Cc2ccccc2)CC1>>O=C(OC1CCN(Cc2ccccc2)CC1)c1ccccc1Br",
        "output": "51"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CCOC(=O)c1cn(-c2ccc(F)cc2F)c2cc(Cl)c(F)cc2c1=O.Cl>>O=C(O)c1cn(-c2ccc(F)cc2F)c2cc(Cl)c(F)cc2c1=O",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CC#N.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CCN",
        "output": "246"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.CC(=O)O.CNCc1ccccc1N(C)C(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(C)cc2)cc1.CO.ClC(Cl)Cl.[BH3-]C#N.[Na+]>>Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N(C)c3ccccc3CN(C)C)cc2)cc1",
        "output": "69"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C1(N)Cc2ccccc2C1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CO.ClCCl.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2sccc2c1>>CCOC(=O)C1(NC(=O)c2ccc3sccc3c2)Cc2ccccc2C1",
        "output": "709"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(=O)(=O)Oc1ccc(CCO)cc1.ClCCl.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.O=C1OC(Cc2ccc(O)cc2)C(=O)N1C(c1ccccc1)(c1ccccc1)c1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CS(=O)(=O)Oc1ccc(CCOc2ccc(CC3OC(=O)N(C(c4ccccc4)(c4ccccc4)c4ccccc4)C3=O)cc2)cc1",
        "output": "550"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COc1cccc(O)c1.ClCCCI.O.[Cl-].[H-].[Na+].[Na+]>>COc1cccc(OCCCCl)c1",
        "output": "198"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1ccccc1.C1CCOC1.CC(=O)c1c(N)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2n(C)c1=O.O=C([O-])[O-].[H-].[K+].[K+].[Na+]>>CC(=O)c1c(NCc2ccccc2)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2n(C)c1=O",
        "output": "272"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCO.COc1ccc(-c2ccc(CCOCc3ccccc3)cc2)cc1.[H][H].[Pd]>>COc1ccc(-c2ccc(CCO)cc2)cc1",
        "output": "178"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)N1CCN(CCC(C)(C)c2ccccc2)CC1.Cl.[Cl-].[Na+]>>CC(C)(CCN1CCNCC1)c1ccccc1",
        "output": "283"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(n2nc(I)c3c(N)ncnc32)CC1.CC(C)=O.CO.Cl.[Na+].[OH-]>>Nc1ncnc2c1c(I)nn2C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC.Cc1ccc(O)c(N)n1.ClCCl.Fc1cccc(F)c1CBr.O.[Cl-].[Na+].[OH-]>>Cc1ccc(OCc2c(F)cccc2F)c(N)n1",
        "output": "623"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccnc2c1ccc1c(OC)ccnc12.CS(=O)(=O)c1ccc(Br)cc1.CS(C)=O.Cl.N#Cc1c[nH]c(=O)cc1O.O.O=C([O-])[O-].[Cu]I.[K+].[K+]>>CS(=O)(=O)c1ccc(-n2cc(C#N)c(O)cc2=O)cc1",
        "output": "349"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.COC(=O)c1c(Cl)cccc1C1CCC1.Cl.[K+].[OH-]>>O=C(O)c1c(Cl)cccc1C1CCC1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CCOc1cc(C=O)cc([N+](=O)[O-])c1O.CN(C)C=O.COc1cccc(CBr)c1.O.O=C([O-])[O-].[I-].[K+].[K+]>>CCOc1cc(C=O)cc([N+](=O)[O-])c1OCc1cccc(OC)c1",
        "output": "127"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)Nc1ccc(CN)cn1.CC(C)(C)OC(=O)Nc1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cn1.Cl>>Nc1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cn1",
        "output": "885"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "N.O=[N+]([O-])c1cc2cc(Br)ccc2nc1Cl>>Nc1nc2ccc(Br)cc2cc1[N+](=O)[O-]",
        "output": "388"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOP(=O)(C/C=C/CNc1c(N)c(=O)c1=O)OCC.C[Si](C)(C)Br.ClCCCl>>Nc1c(NC/C=C/CP(=O)(O)O)c(=O)c1=O",
        "output": "535"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.COc1ccc(S)cc1.O=C([O-])[O-].O=C1CCCN1C(=O)NCCCl.[I-].[K+].[K+].[Na+]>>COc1ccc(SCCNC(=O)N2CCCC2=O)cc1",
        "output": "460"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCOC(=O)c1cc2c(N)cccc2n1C.c1ccncc1>>CCOC(=O)c1cc2c(NC(C)=O)cccc2n1C",
        "output": "365"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCCCc1ccccc1.CN(C)C=O.Cc1cc([N+](=O)[O-])c(N)cc1Cl.N#N.[H-].[Na+]>>Cc1cc([N+](=O)[O-])c(NCCCc2ccccc2)cc1Cl",
        "output": "273"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2nc3sccn3c2-c2ccccc2)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1ccc(-c2nc3sccn3c2-c2ccccc2)cc1",
        "output": "444"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=O.Cc1ccc(C)c(N2CCN(C(=O)[C@H]3CNCC[C@H]3c3ccccc3)CC2)c1.Cl.O=S(=O)(Cl)c1cccc(Cl)c1>>Cc1ccc(C)c(N2CCN(C(=O)[C@H]3CN(S(=O)(=O)c4cccc(Cl)c4)CC[C@H]3c3ccccc3)CC2)c1",
        "output": "99"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.NCC1CCOCC1.O.O=C([O-])[O-].O=S(=O)(Cl)c1ccc(Cl)cc1.[K+].[K+]>>O=S(=O)(NCC1CCOCC1)c1ccc(Cl)cc1",
        "output": "43"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.Nc1cnc2[nH]ccc2c1.O=C(O)c1cc([N+](=O)[O-])c(F)cc1Cl.O=C([O-])[O-].O=S(Cl)Cl.[K+].[K+].c1ccccc1>>O=C(Nc1cnc2[nH]ccc2c1)c1cc([N+](=O)[O-])c(F)cc1Cl",
        "output": "759"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)COc1cccc2c1CCC(COC(=O)N(c1ccccc1)c1ccccc1)C2.Cl.[Na+].[OH-]>>O=C(O)COc1cccc2c1CCC(COC(=O)N(c1ccccc1)c1ccccc1)C2",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)c1ccc(S(=O)(=O)Cl)cc1.CCCCn1c(=O)n(Cc2ccccc2F)c(=O)c2[nH]c(Cc3ccc(N)cc3)nc21>>CCCCn1c(=O)n(Cc2ccccc2F)c(=O)c2[nH]c(Cc3ccc(NS(=O)(=O)c4ccc(C(C)C)cc4)cc3)nc21",
        "output": "68"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CCN(CC)CC.CCOC(C)=O.COC(=O)c1ccc(CNCc2cn(C[Si](C)(C)C)nn2)cc1.ClCCl>>COC(=O)c1ccc(CN(Cc2cn(C[Si](C)(C)C)nn2)C(C)=O)cc1",
        "output": "240"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClC(Cl)Cl.O=C1OC(c2ccccc2)(c2ccccc2)C2CNCCN12.O=S(=O)(Cl)c1ccccc1.c1ccncc1>>O=C1OC(c2ccccc2)(c2ccccc2)C2CN(S(=O)(=O)c3ccccc3)CCN12",
        "output": "99"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(C#N)ccc1S(=O)(=O)N1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(C#N)ccc1S(=O)(=O)N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.Cl.FC1(c2ccc(Cl)cc2)CCNCC1.ICCC(c1ccccc1)c1ccccc1.O=C([O-])[O-].[K+].[K+]>>FC1(c2ccc(Cl)cc2)CCN(CCC(c2ccccc2)c2ccccc2)CC1",
        "output": "184"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.CCCCCC.CCO.COC(=O)c1cc2c(OCc3ccccc3)cncc2s1.[Pd]>>COC(=O)c1cc2c(O)cncc2s1",
        "output": "264"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCN(CC(=O)O)CC1.CCN(C(C)C)C(C)C.ClCCl.F[P-](F)(F)(F)(F)F.Nc1nccs1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CC(C)(C)OC(=O)N1CCN(CC(=O)Nc2nccs2)CC1",
        "output": "681"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1ccc(C2CC(C(=O)O)CN(C(=O)N3CCC(O)CC3)C2)cc1.N=C(NO)c1cccc(F)c1>>CCc1ccc(C2CC(c3nc(-c4cccc(F)c4)no3)CN(C(=O)N3CCC(O)CC3)C2)cc1",
        "output": "895"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)C1(c2cccc(F)c2)CCC(=CC(=O)O)CC1.CN(C)C=O.CN1CCOCC1.NCCc1c[nH]c2ccccc12.O.On1nnc2ccccc21.[Na+].[OH-]>>CN(C)C1(c2cccc(F)c2)CCC(=CC(=O)NCCc2c[nH]c3ccccc23)CC1",
        "output": "549"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NCCN1C(=O)S/C(=C\\c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)C1=O.O=S(=O)(Cl)CCl>>O=C1S/C(=C\\c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)C(=O)N1CCNS(=O)(=O)CCl",
        "output": "493"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(C(C)C)C(C)C.CN(C)C=O.COc1ccc(CC2SC(=O)NC2=O)c2c1N(CC1CCNCC1)C(=O)CC2.O=C1CCOCC1.[Na+]>>COc1ccc(CC2SC(=O)NC2=O)c2c1N(CC1CCN(C3CCOCC3)CC1)C(=O)CC2",
        "output": "187"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=C(N1C2CCC1CC1(C2)Oc2ccccc2-n2cccc21)C(F)(F)F.[Na+].[OH-]>>c1ccc2c(c1)OC1(CC3CCC(C1)N3)c1cccn1-2",
        "output": "703"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCCC.Cl.FC(F)(F)c1ccc(Cl)c(Cl)c1.O.O=C=O.[Li]CCCC>>O=C(O)c1c(C(F)(F)F)ccc(Cl)c1Cl",
        "output": "387"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1ccc(OCCCN2C[C@@H]3CC[C@@H]3C2)cc1.Cl.[Na+].[OH-]>>O=C(O)c1ccc(OCCCN2C[C@@H]3CC[C@@H]3C2)cc1",
        "output": "222"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCN(CCC)C1CCc2cccc(C(=O)OC)c2C1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CCCN(CCC)C1CCc2cccc(CO)c2C1",
        "output": "444"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2nc(-c3cccc(N)c3F)c(-c3ccnc(Cl)n3)s2)CC1.O=S(=O)(Cl)c1c(F)cccc1F.c1ccncc1>>CC(C)(C)OC(=O)N1CCC(c2nc(-c3cccc(NS(=O)(=O)c4c(F)cccc4F)c3F)c(-c3ccnc(Cl)n3)s2)CC1",
        "output": "68"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CN=C2CCCN2C1.CC#N.CCOC(=O)CCCBr.ClCCl.NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl>>CCOC(=O)CCCOC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1NCc1ccco1",
        "output": "416"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCc1ccc(N)cc1.CS(C)=O.O=[N+]([O-])c1ccc(F)cc1>>CCCCCCc1ccc(Nc2ccc([N+](=O)[O-])cc2)cc1",
        "output": "609"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCc1noc(CCNC(=O)OC(C)(C)C)n1.ClCCl.O=C(O)C(F)(F)F>>CCCc1noc(CCN)n1",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)OC(=O)N=NC(=O)OC(C)C.COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ncnc2cc1O.ClCCl.OCCCN1CCOCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ncnc2cc1OCCCN1CCOCC1",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1ccccn1.C1CNCCNC1.O>>c1ccc(N2CCCNCC2)nc1",
        "output": "647"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCN(c2ccc(Cl)c(C(=O)O)n2)CC1.NC(=O)c1nn(-c2ccc3c(c2)OCO3)c2c1CCc1ccc(N)cc1-2>>CN1CCN(c2ccc(Cl)c(C(=O)Nc3ccc4c(c3)-c3c(c(C(N)=O)nn3-c3ccc5c(c3)OCO5)CC4)n2)CC1",
        "output": "548"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#Cc1ccc(N)nc1N.C1CCOC1.CCN(CC)CC.ON=C(Cl)Cc1ccc(Br)cc1>>Nc1ccc(-c2cc(Cc3ccc(Br)cc3)no2)c(N)n1",
        "output": "976"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.CS(=O)(=O)c1nc(OCc2ccc(F)c(F)c2)c(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)n1>>Fc1ccc(COc2nc(N3CCOCC3)nc(-c3ccc(Cl)cc3Cl)c2-c2ccc(Cl)cc2)cc1F",
        "output": "679"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.N#Cc1ccccc1N.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>N#Cc1ccccc1NC(=O)C(F)(F)F",
        "output": "106"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COC(=O)CNc1cc(C(F)(F)F)c2c(-c3ccccc3)nn(C)c2n1.O.[Li+].[OH-]>>Cn1nc(-c2ccccc2)c2c(C(F)(F)F)cc(NCC(=O)O)nc21",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CN1CCN(c2ccc(N)cc2Cl)CC1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Cl>>COc1ccc2nc(Nc3ccc(N4CCN(C)CC4)c(Cl)c3)c3n[nH]cc3c2c1",
        "output": "998"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc2c(n1)C(=O)C(N)=C(Cl)C2=O.O.O=[Se]=O>>NC1=C(Cl)C(=O)c2ccc(C=O)nc2C1=O",
        "output": "619"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCOC(=O)c1c(-c2ccc(Br)cc2)ncn1C.O.O.[Li]O>>Cn1cnc(-c2ccc(Br)cc2)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCC(=O)O.Cl.ClCCCl.O.Oc1cccc(O)c1.[Cl-].[Cl-].[Cl-].[Na+].[Zn+2]>>CCCC(=O)c1ccc(O)cc1O",
        "output": "435"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccccc1N=C=O.NC(N)=O.Nc1ccc(Cl)c(S(N)(=O)=O)c1O>>COc1ccccc1NC(=O)Nc1ccc(Cl)c(S(N)(=O)=O)c1O",
        "output": "473"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cccc(C=O)c1C.Cl.NO.O=CO.[Na+].[OH-]>>COc1cccc(C#N)c1C",
        "output": "453"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCN(CCCO)C(=O)C1=Cc2ccc(C(=O)OC)cc2N=C(NC(=O)OC(C)(C)C)C1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li+].[OH-]>>CCCN(CCCO)C(=O)C1=Cc2ccc(C(=O)O)cc2N=C(NC(=O)OC(C)(C)C)C1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.CO.COCCOc1ccc2c(c1)[nH]c1c(C(N)=O)nnc(-c3cccc(-n4cnc5ccccc5c4=O)c3C)c12.ClCCl.ClCCl>>Cc1c(-c2nnc(C(N)=O)c3[nH]c4cc(OCCO)ccc4c23)cccc1-n1cnc2ccccc2c1=O",
        "output": "423"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.COc1cccc(-c2noc3ccsc23)c1.Cl.ClCCl.O.c1ccncc1>>Oc1cccc(-c2noc3ccsc23)c1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1cccc(Cc2ccco2)c1.C#Cc1ccc(OC(F)F)cc1.CCN(CC)CC.I[Cu]I.[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>FC(F)Oc1ccc(C#Cc2cccc(Cc3ccco3)c2)cc1",
        "output": "659"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cc2c([N+](=O)[O-])cn(Cc3ccc(F)cc3)c2cn1.[Pd]>>COC(=O)c1cc2c(N)cn(Cc3ccc(F)cc3)c2cn1",
        "output": "269"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.O=C(O)Cc1nc2ccccc2s1.c1ccc(CCc2csc(C3CCNCC3)n2)cc1>>O=C(Cc1nc2ccccc2s1)N1CCC(c2nc(CCc3ccccc3)cs2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.CC(C)(C)OC(=O)n1cc(CO)c2ccc(F)cc21.CCN(CC)CC.ClCCl>>CC(=O)OCc1cn(C(=O)OC(C)(C)C)c2cc(F)ccc12",
        "output": "126"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN.Cc1nc(C(C)(NC(=O)c2cc(OCC(F)(F)F)c(C3CC3)cn2)C(=O)O)no1.Cl>>CNC(=O)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(C2CC2)cn1)c1noc(C)n1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCOc1ccc(C(=O)CCC(=O)Nc2cc(Cl)cc(-c3ccccc3)n2)cc1OCC.COCCOC.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.O.O=C([O-])[O-].OB(O)c1ccc(C2CCCCC2)cc1.[K+].[K+].[Pd+2]>>CCOc1ccc(C(=O)CCC(=O)Nc2cc(-c3ccc(C4CCCCC4)cc3)cc(-c3ccccc3)n2)cc1OCC",
        "output": "947"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCCCC/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCC(=O)O.CCCCOC(=O)Cl.CCN(CC)CC.CCN(CC)CC.CO.COC(=O)[C@@H](N)CO.Cl.Cl.Cl>>CCCCC/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCC(=O)N[C@@H](CO)C(=O)OC",
        "output": "129"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrBr.ClCCCl.Fc1ccc(Br)c(F)c1.O=S(=O)([O-])O.[Fe].[Na+]>>Fc1cc(F)c(Br)cc1Br",
        "output": "98"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)Cn1c(C)cccc1=O.NN.O>>Cc1cccc(=O)n1CC(=O)NN",
        "output": "164"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1ccc(CN2CCNCC2)nc1.C1CCOC1.CC(=O)O.ClCCl.O.O=C1CCC1.[BH3-]C#N.[Na+].[Na+].[OH-]>>Brc1ccc(CN2CCN(C3CCC3)CC2)nc1",
        "output": "187"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCc1nc2ccccc2[nH]1.CN(C)C=O.COC(=O)c1ccccc1-c1ccc(CBr)cc1.O.[H-].[Na+]>>CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)OC)cc1",
        "output": "658"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.Nc1cc(Cl)ccn1.O.O=C1CCC(=O)N1Br>>Nc1cc(Cl)c(Br)cn1",
        "output": "518"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1cn(C)c2cc(Cl)ccc2c1=O.CCOCC.CN.FB(F)F>>CNC(=O)c1cn(C)c2cc(Cl)ccc2c1=O",
        "output": "498"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1ccc(N2CCC(N3CCC[C@H](Nc4cc(F)c(S(C)(=O)=O)cc4F)C3=O)CC2)nc1.CO.[BH4-].[Na+]>>CC(O)c1ccc(N2CCC(N3CCC[C@H](Nc4cc(F)c(S(C)(=O)=O)cc4F)C3=O)CC2)nc1",
        "output": "449"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.CCN(C(C)C)C(C)C.CN(C)C=O.ClCCCOc1ccc2c(c1)CCN(C1CCC1)CC2.O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1.[I-].[Na+]>>O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCOc1ccc2c(c1)CCN(C1CCC1)CC2",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CN(C)C=O.COc1ccc2c(c1)CCN(C1CCNCC1)C(=O)N2.Cc1cc(C(=O)c2cc(Cl)ncn2)cc2sc(=O)[nH]c12.O>>COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)c4cc(C)c5[nH]c(=O)sc5c4)ncn3)CC1)C(=O)N2",
        "output": "162"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)c1ncc(C#Cc2ccccc2)cn1.NCC1CCOCC1>>C(#Cc1cnc(NCC2CCOCC2)nc1)c1ccccc1",
        "output": "629"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.Cl.Cl.NCCNc1cccc2ccccc12.O=C(Cl)OCc1ccccc1>>O=C(NCCNc1cccc2ccccc12)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)CC(=O)O.C[C@H](N)COc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12>>C[C@@H](COc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)NC(=O)CN(C)C",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(Nc2cc(NC(=O)c3c(Cl)cccc3Cl)ccn2)cc1.Cl.[Li+].[OH-]>>O=C(O)c1ccc(Nc2cc(NC(=O)c3c(Cl)cccc3Cl)ccn2)cc1",
        "output": "5"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C=CC(=O)Cl.CCN(CC)CC.CN(C)C=O.N#Cc1cnc2ccc(N)cc2c1Nc1ccc(F)c(F)c1.O=C([O-])O.[Na+]>>C=CC(=O)Nc1ccc2ncc(C#N)c(Nc3ccc(F)c(F)c3)c2c1",
        "output": "10"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.ClCCl.OC[C@H]1CC=C[C@H]1O.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OC[C@H]1CC=C[C@H]1O",
        "output": "193"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.O=C1CCC2(CC1)OCCO2.[BH4-].[Na+]>>OC1CCC2(CC1)OCCO2",
        "output": "91"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.C[O-].O=[N+]([O-])c1c(F)cc(F)c(F)c1Nc1ccc(I)cc1F.[Na+]>>COc1cc(F)c([N+](=O)[O-])c(Nc2ccc(I)cc2F)c1F",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1c(OCCCCCCCO)ccnc1CO.ClCCl.O=C([O-])[O-].O=S(Cl)Cl.[Na+].[Na+]>>Cc1c(OCCCCCCCO)ccnc1CCl",
        "output": "594"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "N#Cc1cc2c([nH]c1=O)CCOC2.O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+]>>N#Cc1cc2c(nc1Cl)CCOC2",
        "output": "100"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc2ccc(S(=O)(=O)Cl)cc2c1.ClCCl.Nc1ccc(CN2CC[C@H](N)C2=O)cc1[N+](=O)[O-]>>COc1ccc2ccc(S(=O)(=O)N[C@H]3CCN(Cc4ccc(N)c([N+](=O)[O-])c4)C3=O)cc2c1",
        "output": "596"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1CCCC(C)C1N.Cl.Clc1ncc(Br)c(O[C@@H]2CCOC2)n1>>CC1CCCC(C)C1Nc1ncc(Br)c(O[C@@H]2CCOC2)n1",
        "output": "544"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1C(=O)N(C(=O)[C@H](C)N)c2cccc(N)c2-c2ccccc21.C[C@@](O)(C(=O)O)c1ccccc1>>CC1C(=O)N(C(=O)[C@H](C)NC(=O)[C@@](C)(O)c2ccccc2)c2cccc(N)c2-c2ccccc21",
        "output": "133"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1ncc2[nH]c3ccc([N+](=O)[O-])cc3c2c1C.[C].[Pd]>>CCOC(=O)c1ncc2[nH]c3ccc(N)cc3c2c1C",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)C[C@H](N)C(N)=O.O=C(O)c1ccc(C2(O)COC2)c(OCC2CC2)n1>>CC(C)C[C@H](NC(=O)c1ccc(C2(O)COC2)c(OCC2CC2)n1)C(N)=O",
        "output": "738"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(OCCNC(=O)Cc5ccc(O)cc5)CCC4(C)C3CC(O)C12C.CCOC(=O)C(C)=Cc1cc(F)c(F)c(F)c1.CN(C)C=O.Cl.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C(C)=Cc1cc(F)c(Oc2ccc(CC(=O)NCCOC3CCC4(C)C(C3)CC(O)C3C4CC(O)C4(C)C(C(C)CCC(=O)O)CCC34)cc2)c(F)c1",
        "output": "564"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCn2nc(Nc3cc(-c4ccnc(-n5ncc6cc(C(C)(C)C)cc(F)c6c5=O)c4C=O)nn(C)c3=O)cc2C1.CO.[BH4-].[Na+]>>CN1CCn2nc(Nc3cc(-c4ccnc(-n5ncc6cc(C(C)(C)C)cc(F)c6c5=O)c4CO)nn(C)c3=O)cc2C1",
        "output": "476"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COc1cc([N+](=O)[O-])ccc1N1CCC(N2CCOCC2)CC1.[Pd]>>COc1cc(N)ccc1N1CCC(N2CCOCC2)CC1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1c(Cl)nc2cc(F)cc(F)c2c1Cl.Cc1cc(C(F)(F)F)ccc1B(O)O.Cc1ccccc1.O=C([O-])[O-].[K+].[K+]>>Cc1cc(C(F)(F)F)ccc1-c1nc2cc(F)cc(F)c2c(Cl)c1C",
        "output": "865"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CO.O.O=C(O)c1ccc(O)c2ccccc12.O=S(=O)(O)O>>COC(=O)c1ccc(O)c2ccccc12",
        "output": "195"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)CCN1CCNCC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COC(=O)c1ccc(CCCC(=O)O)c(C)c1.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>COC(=O)c1ccc(CCCC(=O)N2CCN(CCC(C)(C)C)CC2)c(C)c1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1cccc2ccccc12.CC(=O)[O-].CC(=O)[O-].CCO.COCCOC.N#N.O.O=C([O-])[O-].OB(O)c1ccccc1Br.[K+].[K+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Brc1ccccc1-c1cccc2ccccc12",
        "output": "837"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCO.Cc1ccccc1.ClCCl.O.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(F)cc1Br>>CCOC(=O)c1ccc(F)cc1Br",
        "output": "47"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=S(=O)(Nc1cccc(-c2nnn[nH]2)c1)c1ccc(Br)s1.OB(O)c1ccc(F)c(Cl)c1>>O=S(=O)(Nc1cccc(-c2nnn[nH]2)c1)c1ccc(-c2ccc(F)c(Cl)c2)s1",
        "output": "864"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CN.Cc1c(O[C@@H]2CC[C@H](N3C(=O)c4ccccc4C3=O)CC2)ccc2c1cnn2C1CCCCO1>>Cc1c(O[C@@H]2CC[C@H](N)CC2)ccc2c1cnn2C1CCCCO1",
        "output": "242"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCC(C)(C)CO)cc1CC2C(C)(C)C.CO.O.O.[Li]O>>COc1cc2c(cc1OCC(C)(C)CO)CC(C(C)(C)C)n1cc(C(=O)O)c(=O)cc1-2",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(=O)N1c2ccc(-c3ccc(C(=O)NCCNC(=O)OC(C)(C)C)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C.Cl>>CC(=O)N1c2ccc(-c3ccc(C(=O)NCCN)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C",
        "output": "538"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCO.Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(O)C(=O)O)[C@@H](O)[C@H]1O>>CCCCOC(=O)C(O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCO.O=C([O-])[O-].O=c1ccc2ccc(OCCCCl)cc2o1.OC(c1ccc(F)cc1)(c1ccc(F)cc1)C1CCNCC1.[I-].[K+].[Na+].[Na+]>>O=c1ccc2ccc(OCCCN3CCC(C(O)(c4ccc(F)cc4)c4ccc(F)cc4)CC3)cc2o1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CI.CN(C)C=O.Cc1nc([N+](=O)[O-])c[nH]1.O.O=C([O-])[O-].[K+].[K+]>>Cc1nc([N+](=O)[O-])cn1C",
        "output": "404"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)[C@@H]1CCCN(CC#CCN2c3ccccc3CCc3ccccc32)C1.[Na+].[OH-]>>O=C(O)[C@@H]1CCCN(CC#CCN2c3ccccc3CCc3ccccc32)C1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.COc1ccc2nccc(CCC3CCC4(CC3)OCCO4)c2c1.O>>COc1ccc2nccc(CCC3CCC(=O)CC3)c2c1",
        "output": "251"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCCCCCCCCCCCCOCC(O)COC(c1ccccc1)(c1ccccc1)c1ccccc1.CCOCC.Cc1ccc(S(=O)(=O)Cl)cc1.O>>CCCCCCCCCCCCCCCCCCOCC(COC(c1ccccc1)(c1ccccc1)c1ccccc1)OS(=O)(=O)c1ccc(C)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)CC(C)C.Cc1nc2ccccn2c(=O)c1CCCl.Fc1ccc2c(C3CCNCC3)noc2c1.O.O=C([O-])[O-].[I-].[K+].[Na+].[Na+]>>Cc1nc2ccccn2c(=O)c1CCN1CCC(c2noc3cc(F)ccc23)CC1",
        "output": "138"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1cnn(-c2nc3cc(S(=O)(=O)Nc4ccccc4)c(Cl)cc3[nH]2)c1.O.O.[Li+].[OH-]>>O=C(O)c1cnn(-c2nc3cc(S(=O)(=O)Nc4ccccc4)c(Cl)cc3[nH]2)c1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=O.CC(C)c1ccc(N(Cc2ccc(N(C)C)cc2)C(=O)C2CCOc3c(C#N)cccc32)cc1.OO.[Na+].[OH-]>>CC(C)c1ccc(N(Cc2ccc(N(C)C)cc2)C(=O)C2CCOc3c(C(N)=O)cccc32)cc1",
        "output": "180"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCCS(=O)(=O)Nc1cccc(C(O)c2c[nH]c3ncc(C#N)cc23)c1F>>CCCS(=O)(=O)Nc1cccc(C(=O)c2c[nH]c3ncc(C#N)cc23)c1F",
        "output": "852"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CNC(=O)c1c(-c2ccc(F)cc2)oc2nc(Cl)c(Br)cc12.COc1ccc(C(=O)O)cc1B(O)O.Cl[Pd]Cl.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2nc(Cl)c(-c3cc(C(=O)O)ccc3OC)cc12",
        "output": "833"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "FC(F)(F)c1cccc2c(Br)c(Cc3ccccc3)cnc12.O=Cc1cccc(B(O)O)c1>>O=Cc1cccc(-c2c(Cc3ccccc3)cnc3c(C(F)(F)F)cccc23)c1",
        "output": "872"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.O=C(O)c1ccc(Oc2ccc(F)cc2)nc1.O=S(Cl)Cl>>O=C(Cl)c1ccc(Oc2ccc(F)cc2)nc1",
        "output": "188"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)I.CN(C)C=O.CN1C(=O)N(c2ccc(C(F)(F)F)cc2)S(=O)(=O)c2ccc(O)cc21.O=C([O-])[O-].[K+].[K+]>>CC(C)Oc1ccc2c(c1)N(C)C(=O)N(c1ccc(C(F)(F)F)cc1)S2(=O)=O",
        "output": "318"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cn1.COCCOC.Cl[Pd]Cl.O.O=C([O-])[O-].Oc1ccc2cc(Br)ccc2c1.[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COC(=O)c1ccc(-c2ccc3cc(O)ccc3c2)cn1",
        "output": "954"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCc1ccc(I)n2nc(C(F)(F)F)cc12.CCCC[N+](CCCC)(CCCC)CCCC.O.[F-]>>OCc1ccc(I)n2nc(C(F)(F)F)cc12",
        "output": "708"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C(C(=O)O)c1ccc(Cl)cc1.CN.O=C(Cl)C(=O)Cl>>CNC(=O)C(c1ccc(Cl)cc1)C(C)C",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.C[O-].Cl.Fc1ccccc1Cn1nc(-c2nc(Cl)c(F)c(Cl)n2)cc1-c1ccon1.[Na+]>>COc1nc(-c2cc(-c3ccon3)n(Cc3ccccc3F)n2)nc(Cl)c1F",
        "output": "461"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CO.COC(=O)C(N)P(=O)(OC)OC.COC(=O)C(NC(=O)OCc1ccccc1)P(=O)(OC)OC.F[P-](F)(F)(F)(F)F.O=C(CCc1cccc(O)c1)c1ccc(C(=O)O)c(Cl)c1.On1nnc2ccccc21>>COC(=O)C(NC(=O)c1ccc(C(=O)CCc2cccc(O)c2)cc1Cl)P(=O)(OC)OC",
        "output": "652"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.Cl.F[B-](F)(F)F.N[C@@H]1CC[C@@H](CCN2CCCCC2c2coc3cccc-3c2)CC1.[Na+].[OH-]>>CC(=O)N[C@@H]1CC[C@@H](CCN2CCCCC2c2coc3cccc-3c2)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COc1cc(C)c2c(ccn2C(=O)OC(C)(C)C)c1Cc1nc2cc(C#N)ccc2[nH]1.O=C([O-])[O-].[Cs+].[Cs+]>>COc1cc(C)c2[nH]ccc2c1Cc1nc2cc(C#N)ccc2[nH]1",
        "output": "848"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC1CC(NC2CCCCC2)CCN1C(=O)OC(C)(C)C.CN(C)C=O.FC(F)(F)c1cc(CBr)cc(C(F)(F)F)c1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CCC1CC(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCCCC2)CCN1C(=O)OC(C)(C)C",
        "output": "248"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.CC(C)CCCC(C)CCCC(C)CCCC(C)(O)C(O)CO.Cc1ccccc1S(=O)(=O)O>>CC(C)CCCC(C)CCCC(C)CCCC(C)(O)C1COC(C)(C)O1",
        "output": "265"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CSC(c1ccccc1)(c1ccccc1)c1ccccc1.CC(C)(C)Oc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1.CN(C)C=O.On1nnc2ccccc21>>CC(C)(C)OC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)NC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21",
        "output": "133"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O.O.O=C(CCCl)N1c2ccccc2CCc2ccccc21.[BH4-].[Na+]>>ClCCCN1c2ccccc2CCc2ccccc21",
        "output": "112"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCN(C)S(=O)(=O)c1cc(C(=O)O)c(OCc2ccccc2)cc1OCc1ccccc1.O=S(Cl)Cl>>CCCN(C)S(=O)(=O)c1cc(C(=O)Cl)c(OCc2ccccc2)cc1OCc1ccccc1",
        "output": "3"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)c1cc(C(C)C)c(C(=O)CBr)c(C(C)C)c1.CCO.NC(N)=S>>CC(C)c1cc(C(C)C)c(-c2csc(N)n2)c(C(C)C)c1",
        "output": "716"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc2nc(Cl)nc(-c3cccc([N+](=O)[O-])c3)c2cc1OC.Cl.NC1CC1>>COc1cc2nc(NC3CC3)nc(-c3cccc([N+](=O)[O-])c3)c2cc1OC",
        "output": "544"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN1CCC(=O)CC1.ClCCCl.Nc1ccccc1I.[Na+]>>CN1CCC(Nc2ccccc2I)CC1",
        "output": "469"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCC(=O)CC1.CO.Cl.N[C@@H]1CCn2c(=O)[nH]c3cccc(c32)[C@H]1O.[BH3-]C#N.[Na+].[Na+].[OH-]>>CN1CCC(N[C@@H]2CCn3c(=O)[nH]c4cccc(c43)[C@H]2O)CC1",
        "output": "236"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CNc1nc2cc(C(=O)OC)ccc2[nH]1.Cl>>CNc1nc2cc(C(=O)O)ccc2[nH]1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCO.CCOC(=O)CC(=O)c1ccc2c(cnn2CC)c1.Cc1cc(-c2cn[nH]c2N)[nH]n1.Cc1ccc(S(=O)(=O)O)cc1>>CCn1ncc2cc(-c3cc(=O)n4ncc(-c5cc(C)n[nH]5)c4[nH]3)ccc21",
        "output": "513"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(CCc2noc3cc(OCC4CC4)c(CO)cc23)CC1.CCN(CC)CC.CNC.CS(=O)(=O)Cl.[Cl-].[I-].[Na+].[Na+]>>CN(C)Cc1cc2c(CCC3CCN(C(=O)OC(C)(C)C)CC3)noc2cc1OCC1CC1",
        "output": "765"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cc1cc(OCCO[Si](C)(C)C(C)(C)C)c(F)cc1Br.CO.O.[Li]O>>CC(C)(C)[Si](C)(C)OCCOc1cc(CC(=O)O)c(Br)cc1F",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(Cl)cc(Cl)c1S(=O)(=O)Cl.Nc1cccc(COCc2cccc(Cl)c2)n1>>Cc1cc(Cl)cc(Cl)c1S(=O)(=O)Nc1cccc(COCc2cccc(Cl)c2)n1",
        "output": "462"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CNCCOC.CS(=O)(=O)c1nccc(Oc2ccc(NC(=O)c3cc(F)cc(N4CCCCC4)c3)c3ccccc23)n1>>COCCN(C)c1nccc(Oc2ccc(NC(=O)c3cc(F)cc(N4CCCCC4)c3)c3ccccc23)n1",
        "output": "679"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCc1nc2ccccn2c(=O)c1Br.COc1ccc(B(O)O)cc1.O=c1c(Br)c(C(F)(F)F)nc2ccccn12.OB(O)c1ccc(Cl)cc1>>O=c1c(-c2ccc(Cl)cc2)c(C(F)(F)F)nc2ccccn12",
        "output": "871"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)CC1(C(CCN)C(=O)OC(C)(C)C)CCN(CCc2ccccc2)C1=O.CCN(C(C)C)C(C)C.ClCCl.O=C(Cl)c1ccc(F)c(F)c1>>CC(C)CC1(C(CCNC(=O)c2ccc(F)c(F)c2)C(=O)OC(C)(C)C)CCN(CCc2ccccc2)C1=O",
        "output": "271"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)CNC(=O)c1nnc2ccc(Cl)nn12.CN(C)C=O.NCCCN1CCC(OC(c2ccccc2)c2ccccc2)CC1.O>>CCOC(=O)CNC(=O)c1nnc2ccc(NCCCN3CCC(OC(c4ccccc4)c4ccccc4)CC3)nn12",
        "output": "241"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCC.CCCCO.CCOC(C)=O.CCOC(C)=O.COCCOC.COc1cc(OC)cc(OCCCCl)c1.Fc1ccc(C(c2ccc(F)cc2)C2CCNCC2)cc1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>COc1cc(OC)cc(OCCCN2CCC(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c1",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)COc1cccc(N(C)C(=O)OC(C)(C)C)c1.O.[Li+].[OH-]>>CN(C(=O)OC(C)(C)C)c1cccc(OCC(=O)O)c1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N[C@H]1CCC[C@@H]1C(=O)O.CCN(CC)CC.CCOC(=O)Cl.Cl.O.[BH4-].[Na+]>>CC(C)(C)OC(=O)N[C@H]1CCC[C@@H]1CO",
        "output": "231"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cccc(Nc2cc(N[C@@H]3CCOC[C@@H]3NC(=O)OC(C)(C)C)nnc2C(N)=O)n1.ClCCl.O=C(O)C(F)(F)F>>Cc1cccc(Nc2cc(N[C@@H]3CCOC[C@@H]3N)nnc2C(N)=O)n1",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)CCCOc1cc(Cl)ccc1NC(=S)NN=C(C)c1nn(C)c(-c2ccc(C(F)(F)F)cc2)c1O.Cl.[Na+].[OH-]>>CC(=NNC(=S)Nc1ccc(Cl)cc1OCCCC(=O)O)c1nn(C)c(-c2ccc(C(F)(F)F)cc2)c1O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CCOC(=O)CCCCCn1c2ccccc2c(=O)c2ccccc21.Cl>>O=C(O)CCCCCn1c2ccccc2c(=O)c2ccccc21",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.N#Cc1ccc(-c2cc(NC3CCc4ccccc43)nc(N)n2)cc1F.NN.O>>Nc1nc(NC2CCc3ccccc32)cc(-c2ccc3c(N)n[nH]c3c2)n1",
        "output": "945"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.C[C@H](N1CC[C@](CCN)(c2ccc(F)cc2)OC1=O)C(C)(C)C.ClCCl>>C[C@H](N1CC[C@](CCNS(C)(=O)=O)(c2ccc(F)cc2)OC1=O)C(C)(C)C",
        "output": "493"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCNc1ccc(CC(=O)O)cc1.CCOCC.CCOCCO.Cc1ccccc1.FB(F)F>>C=CCNc1ccc(CC(=O)OCCOCC)cc1",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)Cl.O.O=C(O)c1ccc2ncc(Br)cc2c1.[BH4-].[Na+]>>OCc1ccc2ncc(Br)cc2c1",
        "output": "72"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cnc(N2CC(Oc3cc(F)ccc3Br)C2)nc1.CO.[Li+].[OH-]>>O=C(O)c1cnc(N2CC(Oc3cc(F)ccc3Br)C2)nc1",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COCCCCC(=O)c1ccccc1.[Cl-].[NH3+]O.c1ccncc1>>COCCCC/C(=N/O)c1ccccc1",
        "output": "212"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCCO.Cl.Cn1ccnc1Sc1ccc(N)cc1Cl.N#Cc1cnc2cc(F)ccc2c1Cl.c1ccncc1>>Cn1ccnc1Sc1ccc(Nc2c(C#N)cnc3cc(F)ccc23)cc1Cl",
        "output": "115"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Nc1cc2ncnc(Nc3cccc(Br)c3)c2cc1[N+](=O)[O-].[Fe]>>Nc1cc2ncnc(Nc3cccc(Br)c3)c2cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C[C@@H]1CCCN(C(=O)c2c(F)cccc2-c2ncccn2)[C@@H]1CN.FC(F)(F)c1cnc(Cl)nc1>>C[C@@H]1CCCN(C(=O)c2c(F)cccc2-c2ncccn2)[C@@H]1CNc1ncc(C(F)(F)F)cn1",
        "output": "544"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(CC[C@H]1CCC[C@@H](OCCN(Cc2ccc(C)cc2)C(=O)NC2CCCCC2)C1)C(=O)OC(C)(C)C.Cc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>CCC(CC[C@H]1CCC[C@@H](OCCN(Cc2ccc(C)cc2)C(=O)NC2CCCCC2)C1)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CC[O-].Cc1nc(Cl)nc(C)c1N1CCCn2c1nc1c(Cl)ccc(C(OC(F)F)C(F)(F)F)c12.[Na+]>>CCOc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc(C(OC(F)F)C(F)(F)F)c23)c(C)n1",
        "output": "37"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.C1COCCO1.CN(C)CCn1cc([N+](=O)[O-])cn1.CO.Cl>>CN(C)CCn1cc(N)cn1",
        "output": "628"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCc1ccc(Oc2ccc(NCCO)cc2F)c(OCc2ccccc2)c1.CO>>CCc1ccc(Oc2ccc(NCCO)cc2F)c(O)c1",
        "output": "23"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.CO.COC(=O)NC(CCSC)(CCc1ccccc1)C(=O)OC.ClCCl.O.O=S([O-])OO.[K+]>>COC(=O)NC(CCc1ccccc1)(CCS(C)(=O)=O)C(=O)OC",
        "output": "847"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.C[Si](C)(C)CCN1C(=O)CN(c2ccc(O)cc2OCc2ccccc2)S1(=O)=O.OCCc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C[Si](C)(C)CCN1C(=O)CN(c2ccc(OCCc3ccccc3)cc2OCc2ccccc2)S1(=O)=O",
        "output": "478"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C4(CC#N)CC(O)C4)c3)ncnc21.ClCCl.[Na+].[OH-]>>C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C4(CC#N)CC(=O)C4)c3)ncnc21",
        "output": "87"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cn(-c2cc(NC(C)=O)ncc2C)nc1I.CO.Cl>>CC(=O)Nc1cc(-n2cc(C(=O)O)c(I)n2)c(C)cn1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[O-].CCCO.CN(C)C=O.Cc1cc(F)ccc1I.[K+]>>CCCOc1ccc(I)c(C)c1",
        "output": "485"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCCCCCCCNC(=O)c1ccc([N+](=O)[O-])cc1.[Pd]>>CCCCCCCCCCNC(=O)c1ccc(N)cc1",
        "output": "28"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C(=O)Cl)c1ccccc1.Cc1nc(N)c2nc(C)n(CCCN)c2c1C>>Cc1nc(N)c2nc(C)n(CCCNC(=O)N(C)c3ccccc3)c2c1C",
        "output": "454"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)/N=N/C(=O)OCC.COc1cc(NCc2cc3cc(Cl)c(O)cc3[nH]c2=O)ccc1C#N.OCCN1CCOCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc(NCc2cc3cc(Cl)c(OCCN4CCOCC4)cc3[nH]c2=O)ccc1C#N",
        "output": "478"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1sc2cc(O)ccc2c1C(=O)NC.Cn1ccnc1-c1cc2nccc(Cl)c2s1.O=C([O-])[O-].[Cs+].[Cs+]>>CCc1sc2cc(Oc3ccnc4cc(-c5nccn5C)sc34)ccc2c1C(=O)NC",
        "output": "936"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C(=O)O)c1ccc(S(=O)(=O)/C=C/C#N)cc1.CC(C)(C)OC(=O)NCCOCCOCCN.CCN(C(C)C)C(C)C.ClCCl>>CC(C)(C)OC(=O)NCCOCCOCCNC(=O)C(C)(C)c1ccc(S(=O)(=O)/C=C/C#N)cc1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.COc1ccc(C)c(Cl)c1.O.O=[N+]([O-])O>>COc1cc(Cl)c(C)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.Cc1ccccc1.N.O=C(CCl)Cc1ccccc1.c1ccc(N2CCNCC2)nc1>>O=C(Cc1ccccc1)CN1CCN(c2ccccn2)CC1",
        "output": "414"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)c1nn(-c2cccc(Cl)c2)c2c1CCN(c1ccc(I)cc1)C2=O.ClCCl.O=C([O-])[O-].O=C1CCCCN1.[K+].[K+].[NH4+].[OH-].c1cnc2c(c1)ccc1cccnc12>>CS(=O)(=O)c1nn(-c2cccc(Cl)c2)c2c1CCN(c1ccc(N3CCCCC3=O)cc1)C2=O",
        "output": "921"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCc1ccc(C(=O)Cl)cc1.Nc1ccccc1O.c1ccccc1.c1ccncc1>>CCc1ccc(C(=O)Nc2ccccc2O)cc1",
        "output": "11"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.O=C1N(CCCCCl)CCN1N=Cc1ccccc1.[I-].[Na+]>>O=C1N(CCCCI)CCN1N=Cc1ccccc1",
        "output": "97"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)[C@H](CNc1ncnc2c1ncn2CCCC(=O)NC1=NCCCN1)NC(=O)OCc1ccccc1.O.O=C(O)C(F)(F)F>>O=C(CCCn1cnc2c(NC[C@H](NC(=O)OCc3ccccc3)C(=O)O)ncnc21)NC1=NCCCN1",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cl.O.O=C1OCc2cc(CC3OCCO3)ccc21>>O=CCc1ccc2c(c1)COC2=O",
        "output": "740"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCN.O=C(O)CSC(c1ccc(F)cc1)c1ccc(F)cc1>>CCCNC(=O)CSC(c1ccc(F)cc1)c1ccc(F)cc1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)CCCCN1CCN(Cc2ccc(-c3cc4nccc(Oc5ccc(NC(=O)NC6CC6)cc5F)c4s3)nc2)CC1.CO.[Na+].[OH-]>>O=C(O)CCCCN1CCN(Cc2ccc(-c3cc4nccc(Oc5ccc(NC(=O)NC6CC6)cc5F)c4s3)nc2)CC1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN.Cl.ClCCc1cccnc1.[Cl-].[Na+].[Na+].[OH-]>>CNCCc1cccnc1",
        "output": "279"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN.O=C(O)c1cccc2cc(O)ccc12>>CNC(=O)c1cccc2cc(O)ccc12",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](OC1CN(S(=O)(=O)NC(=O)c2cc(C3CC3)c(OCC34CC5CC(CC(C5)C3)C4)cc2F)C1)(c1ccccc1)c1ccccc1.CCCC[N+](CCCC)(CCCC)CCCC.ClCCl.[F-]>>O=C(NS(=O)(=O)N1CC(O)C1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F",
        "output": "781"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.COCCOCCOCCBr.Nc1cc(O)cc(F)c1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>COCCOCCOCCOc1cc(N)cc(F)c1",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.ClCCCl.ClCCl.O=C(O)C1CCN(C(=O)c2cc3ccccc3n2Cc2ccc(Cl)cc2)CC1.On1nnc2ccccc21.c1ccc(C2CCCN2)cc1>>O=C(c1cc2ccccc2n1Cc1ccc(Cl)cc1)N1CCC(C(=O)N2CCCC2c2ccccc2)CC1",
        "output": "633"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)c1ccc(S(=O)(=O)Cl)cc1.Cc1ncccc1C(=O)c1cc(Cl)ccc1N>>CC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cccnc2C)cc1",
        "output": "68"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)N.Cc1ccccc1.O=Cc1ccc(F)cc1F>>CC(C)(C)N=Cc1ccc(F)cc1F",
        "output": "52"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.O=C(N[C@H]1CCCNC1)c1c[nH]c2c(-c3c(OCC4CC4)ccc4c3OCO4)ncnc12>>CC(=O)N1CCC[C@H](NC(=O)c2c[nH]c3c(-c4c(OCC5CC5)ccc5c4OCO5)ncnc23)C1",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(-c2oncc2C(=O)O)cc1.Cc1ccc(CC2CCNC2)cc1.Cl>>Cc1ccc(CC2CCN(C(=O)c3cnoc3-c3ccc(C)cc3)C2)cc1",
        "output": "975"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.N#Cc1ccc(-c2cc(-c3ccccc3)nc(N)n2)cc1F.NN.O>>Nc1nc(-c2ccccc2)cc(-c2ccc3c(N)n[nH]c3c2)n1",
        "output": "945"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCn1nc(C(C)C)c(O)c(C2=Nc3ccc(O)cc3S(=O)(=O)N2)c1=O.CN(C)C=O.NC(=O)CBr.O=C([O-])[O-].[K+].[K+]>>CCCCn1nc(C(C)C)c(O)c(C2=Nc3ccc(OCC(N)=O)cc3S(=O)(=O)N2)c1=O",
        "output": "778"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO[PH](=O)CCCCc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(-c4cnn(CCCO)c4)nc3C(=O)NC)n2)c(OC)c1.C[Si](C)(C)Br.c1ccncc1>>CNC(=O)c1nc(-c2cnn(CCCO)c2)ccc1Nc1nc(Nc2ccc(CCCC[PH](=O)O)cc2OC)ncc1C(F)(F)F",
        "output": "618"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)CC(CBr)CCO1.CN(C)C=O.COC(=O)c1cnc(-c2cc(OC)ccc2F)c(O)c1.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cnc(-c2cc(OC)ccc2F)c(OCC2CCOC(C)(C)C2)c1",
        "output": "608"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOc1cc(C=O)cc2c1OC(C)C(=O)N2.CNC(=O)c1ccc(N2CCNCC2)cc1>>CCOc1cc(CN2CCN(c3ccc(C(=O)NC)cc3)CC2)cc2c1OC(C)C(=O)N2",
        "output": "567"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1ccccc1OCC(F)(F)F.ClCCl.O=C([O-])O.[Na+]>>Oc1ccccc1OCC(F)(F)F",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.Cc1cc(Cl)ccc1OC1CCNCC1.Cl.ClCCl.O.O=C(Cl)C1CC=CC1>>Cc1cc(Cl)ccc1OC1CCN(C(=O)C2CC=CC2)CC1",
        "output": "125"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Nc1cc(Cl)cc(-c2ccccc2)n1.O=C(O)C(F)(F)F>>Nc1cc(Cl)cc(-c2ccccc2)n1",
        "output": "885"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1ccccc1OCC(O)CN1CCNCC1.Cc1cccc(C)c1NC(=O)CCl.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1",
        "output": "340"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1c(C(=O)O)cc(Cl)cc1N(C)C1CCOCC1.Cc1cc(C)c(CN)c(=O)[nH]1.F[P-](F)(F)(F)(F)F>>COc1c(C(=O)NCc2c(C)cc(C)[nH]c2=O)cc(Cl)cc1N(C)C1CCOCC1",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.O=C(OCc1ccc([N+](=O)[O-])cc1)N1C[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1CO>>CS(=O)(=O)OC[C@@H]1C[C@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)CN1C(=O)OCc1ccc([N+](=O)[O-])cc1",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)C[AlH]CC(C)C.CCCNC(=O)CC(C)(C)O.Cc1ccccc1>>CCCNCCC(C)(C)O",
        "output": "112"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.FCCBr.O.O=C([O-])O.[Na+].c1ccc2c(-c3cn(-c4ccc(C5CCNCC5)cc4)nn3)n[nH]c2c1>>FCCN1CCC(c2ccc(-n3cc(-c4n[nH]c5ccccc45)nn3)cc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CN1CCNCC1.Clc1nc2cccnc2nc1Cl.[Cl-].[NH4+]>>CN1CCN(c2nc3ncccc3nc2Cl)CC1",
        "output": "505"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.O=C(c1nn(-c2ccccc2)cc1[N+](=O)[O-])N1CCOCC1.[Pd]>>Nc1cn(-c2ccccc2)nc1C(=O)N1CCOCC1",
        "output": "628"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)OB(c2ccc(N3CCC(O)CC3)cc2)OC1(C)C.CI.CN(C)C=O.[H-].[Na+]>>COC1CCN(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1",
        "output": "140"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1cnc(Br)cn1.CS(C)=O.Cl.FC1(F)CCNCC1.O.O=C([O-])[O-].[Cs+].[Cs+]>>FC1(F)CCN(c2cnc(Br)cn2)CC1",
        "output": "211"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CN(C)C1(c2ccccc2)CCC(N)CC1.O=C(NCCCc1ccccc1)Oc1ccccc1>>CN(C)C1(c2ccccc2)CCC(NC(=O)NCCCc2ccccc2)CC1",
        "output": "488"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C1COCCN1.CCOC(=O)C(C)N1C(=O)COc2cc(F)c(OC(C)=O)cc21>>CCOC(=O)C(C)N1C(=O)COc2cc(F)c(O)cc21",
        "output": "22"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1cccc(Br)n1.CCO.CC[O-].O=C([O-])O.[Na+].[Na+]>>CCOc1cccc(Br)n1",
        "output": "551"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(C(=O)O)nc2s1.CCN(CC)CC.CCOC(=O)CCN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F>>CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(C(=O)NCCC(=O)OCC)nc2s1",
        "output": "951"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)NC1(C(=O)c2ccc(F)cc2F)CC1.CCO.CCOC(C)=O.[BH4-].[Cl-].[NH4+].[Na+]>>CC(=O)NC1(C(O)c2ccc(F)cc2F)CC1",
        "output": "24"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.C[C@H]1COCCN1c1nc(Cl)nc2c1CNC2.Cl.O=C(O)C(F)(F)F.[Na+]>>CC(C)N1Cc2nc(Cl)nc(N3CCOC[C@@H]3C)c2C1",
        "output": "187"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCCCCC1CC1>>CS(=O)(=O)OCCCCC1CC1",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CCC(NC(=O)OC)C1CCC2(CC1)OCCO2.Cl>>CCC(NC(=O)OC)C1CCC(=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.Cc1c(O)cccc1[N+](=O)[O-].O=[N+]([O-])c1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)c1ccc([N+](=O)[O-])c(C)c1O",
        "output": "31"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC(COS(C)(=O)=O)CC1.CCOC(C)=O.CN(C)C=O.COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ncnc2cc1O.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ncnc2cc1OCC1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "702"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)OCc1cc(C(=O)NC(C)c2cnc(OCC(F)(F)F)c(C)c2)cc(Cl)n1.Cl.[Na+].[OH-]>>Cc1cc(C(C)NC(=O)c2cc(Cl)nc(CO)c2)cnc1OCC(F)(F)F",
        "output": "348"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(=O)c1ccc(N(C)C(=O)c2cc3c(s2)-c2ccc(C(=O)O)cc2OCC3)c(Cl)c1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.NCCO>>CN(C)C(=O)c1ccc(N(C)C(=O)c2cc3c(s2)-c2ccc(C(=O)NCCO)cc2OCC3)c(Cl)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CI.O.O=C([O-])[O-].O=Cc1cccc(O)c1Br.[K+].[K+]>>COc1cccc(C=O)c1Br",
        "output": "62"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(=O)CC1.CC(Cl)Cl.CCOCC.Nc1ccc(Cl)c(Cl)c1.[Na+].[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(Nc2ccc(Cl)c(Cl)c2)CC1",
        "output": "469"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.O=S(Cl)Cl.OCc1ccc(F)cn1>>Fc1ccc(CCl)nc1",
        "output": "594"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.CCCCCC.CCCCCCCCC1Cc2ccc(Br)cc2C1.Cl.[Li]CCCC>>CCCCCCCCC1Cc2ccc(B(O)O)cc2C1",
        "output": "832"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.CCN(CC)CC.NCCc1c[nH]c2ccccc12>>CC(=O)NCCc1c[nH]c2ccccc12",
        "output": "339"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CON(C)C(=O)Cc1ccccc1.ClCCl.O=C(Cl)CCCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CON(C)C(=O)Cc1ccc(C(=O)CCCCl)cc1",
        "output": "31"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCOC(=O)Cl.CCN(CC)CC.ClCCl.NC1CCN(C(=O)OCc2ccccc2)CC1>>CCCCOC(=O)NC1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "94"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCCC12CCCN(c1ncnc3[nH]ccc13)C2.CCOC(C)=O.CO.Cl.Cl.ClC(Cl)Cl>>c1nc(N2CCCC3(CCCN3)C2)c2cc[nH]c2n1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN.CCN(CC)CC.O=C(O)c1cc([N+](=O)[O-])ccc1Cl.O=C(n1ccnc1)n1ccnc1>>CCNC(=O)c1cc([N+](=O)[O-])ccc1Cl",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc([C@@H]2CN(Cc3ccccc3)C[C@H]2N)cc1.Cn1nccc1Nc1cc2cc(C(=O)O)ccc2cn1.F[P-](F)(F)(F)(F)F>>COc1ccc([C@@H]2CN(Cc3ccccc3)C[C@H]2NC(=O)c2ccc3cnc(Nc4ccnn4C)cc3c2)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCC(CC)(c1ccc(/C=C/C2(O)CCSCC2)c(C)c1)c1ccc(B2OC(C)(C)C(C)(C)O2)c(C)c1.COC(=O)Cc1ccc(Br)cc1.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1ccccc1.O.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd+2]>>CCC(CC)(c1ccc(/C=C/C2(O)CCSCC2)c(C)c1)c1ccc(-c2ccc(CC(=O)OC)cc2)c(C)c1",
        "output": "933"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CO.COC(=O)c1ccc(C#CCN2C(=O)CC[C@@H]2C(=O)O)s1.COC(=O)c1ccc(CCN2C(=O)CC[C@@H]2CO)cc1.ClCCl>>COC(=O)c1ccc(C#CCN2C(=O)CC[C@@H]2CO)s1",
        "output": "218"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCc1cc2c(CO)ccc(OC)n2n1.ClCCl.[Mn+4].[O-2].[O-2]>>CCc1cc2c(C=O)ccc(OC)n2n1",
        "output": "520"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)[C@@H](N)Cc1ccc(F)c(Br)c1.Cl.O=C(O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nccnc12>>COC(=O)[C@H](Cc1ccc(F)c(Br)c1)NC(=O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nccnc12",
        "output": "652"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(CN(C(=O)C(Cc1ccc(Cl)cc1)NC(=O)C(CN)NC(=O)OCc1ccccc1)C(C)C)OCC.ClCCl.O=S(=O)(Cl)c1ccc(Cl)cc1Cl>>CCOC(CN(C(=O)C(Cc1ccc(Cl)cc1)NC(=O)C(CNS(=O)(=O)c1ccc(Cl)cc1Cl)NC(=O)OCc1ccccc1)C(C)C)OCC",
        "output": "43"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCNc1nc(N)nc(C)c1Cc1ccc(CCl)cc1.CN(C)C=O.CS(C)=O.[C-]#N.[K+]>>CCCCCNc1nc(N)nc(C)c1Cc1ccc(CC#N)cc1",
        "output": "38"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C=O.CC(C)(C)c1cc(-c2ccccc2)ccc1O.CCN(CC)CC.CC[Mg]Br.Cc1ccccc1>>CC(C)(C)c1cc(-c2ccccc2)cc(C=O)c1O",
        "output": "451"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCc1nc2ccc(C(=O)N(C)CCCC)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.O=C(O)C(F)(F)F>>CCCCc1nc2ccc(C(=O)N(C)CCCC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C(=O)Cl)c1ccccc1.Oc1ccc(-c2nc(-c3ccc(Cl)cc3)cs2)cc1>>CN(C(=O)Oc1ccc(-c2nc(-c3ccc(Cl)cc3)cs2)cc1)c1ccccc1",
        "output": "425"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.O.O=C1CN(c2ccc(-c3cncs3)cc2OCc2ccccc2)S(=O)(=O)N1.[Pd]>>O=C1CN(c2ccc(-c3cncs3)cc2O)S(=O)(=O)N1",
        "output": "23"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)C12CCC(C(=O)N3CC[C@](c4ccc(C(F)(C(F)(F)F)C(F)(F)F)c(F)c4)(S(=O)(=O)c4ccc(F)cc4)C3)(CC1)CC2.Cl.[Na+].[OH-]>>O=C(O)C12CCC(C(=O)N3CC[C@](c4ccc(C(F)(C(F)(F)F)C(F)(F)F)c(F)c4)(S(=O)(=O)c4ccc(F)cc4)C3)(CC1)CC2",
        "output": "361"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C1CNC1.Clc1nc2ccccc2[nH]1.O.O>>c1ccc2[nH]c(N3CCC3)nc2c1",
        "output": "36"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=O.CCN(CC)CC.CO.O=C(/C=C/c1cnc2c(c1)CC1(CCNCC1)C(=O)N2)N1CC=C(Cc2nccs2)CC1.O=C(O)C(F)(F)F.[BH4-].[Na+]>>CN1CCC2(CC1)Cc1cc(/C=C/C(=O)N3CC=C(Cc4nccs4)CC3)cnc1NC2=O",
        "output": "217"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)c1ncccc1-c1cc2cc(CC(=O)OCc3ccccc3)ccc2o1.[Pd]>>COC(=O)c1ncccc1-c1cc2cc(CC(=O)O)ccc2o1",
        "output": "186"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.N[C@H]1CCCNC1.O=C(NCC12CC3CC(CC(C3)C1)C2)c1c(Cl)ccc2nc(Cl)ccc12.O=C([O-])O.[Na+]>>N[C@H]1CCCN(c2ccc3c(C(=O)NCC45CC6CC(CC(C6)C4)C5)c(Cl)ccc3n2)C1",
        "output": "220"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.Clc1nccn2c(N3CCC3)nc(Br)c12.N>>Nc1nccn2c(N3CCC3)nc(Br)c12",
        "output": "682"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCS(=O)(=O)c1ccc([C@@H](N)COC)cc1.CC[C@H]1c2ncc(C(=O)O)cc2CN1C(=O)OC(C)(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O>>CC[C@H]1c2ncc(C(=O)N[C@@H](COC)c3ccc(S(=O)(=O)CC)cc3)cc2CN1C(=O)OC(C)(C)C",
        "output": "790"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(N)cc1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(NS(C)(=O)=O)cc1",
        "output": "194"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)/C=C/C(=O)c1nn(-c2ccc(C(F)(F)F)cc2)ccc1=O.NNc1cccc2ccccc12>>O=c1ccn(-c2ccc(C(F)(F)F)cc2)nc1-c1ccnn1-c1cccc2ccccc12",
        "output": "984"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCC1(C(=O)O)CC1.NN.O.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)NCC1(C(=O)NN)CC1",
        "output": "459"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1ccc(N2CC(NC(=O)c3ccccc3)CC2=O)cc1F.ClCCl>>O=C(NC1CC(=O)N(c2ccc(O)c(F)c2)C1)c1ccccc1",
        "output": "402"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)CCOCCc1cccc(C#C[Si](C)(C)C)c1.CO.ClCCl.O.O=C([O-])[O-].[K+].[K+]>>C#Cc1cccc(CCOCCC(=O)OC(C)(C)C)c1",
        "output": "337"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(=O)Cn1nc(C(C)(C)C)cc1NC(=O)Oc1ccccc1.COCCOc1cc2ncnc(Sc3cccc(N)c3)c2cc1OC>>CCOC(=O)Cn1nc(C(C)(C)C)cc1NC(=O)Nc1cccc(Sc2ncnc3cc(OCCOC)c(OC)cc23)c1",
        "output": "948"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CN(C)C=O.NC1CCc2c([N+](=O)[O-])cc3[nH]c(=O)c(=O)[nH]c3c2C1>>CC(=O)NC1CCc2c([N+](=O)[O-])cc3[nH]c(=O)c(=O)[nH]c3c2C1",
        "output": "339"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)CCc1nc2ncccc2c(=O)[nH]1.CO.ClCCl.O=C(O)C(F)(F)F>>O=C(O)CCc1nc2ncccc2c(=O)[nH]1",
        "output": "278"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1.O=S(=O)(Cl)NC1CC1>>O=S(=O)(Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1)NC1CC1",
        "output": "395"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCCCCCCCCBr.CC(C)(C)c1ccc(O)cc1.CN1CCCC1=O.COCCOC.Cc1cccc(OCCCCCCCCBr)c1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)c1ccc(OCCCCCCCCBr)cc1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)Cc1c(C(=O)c2ccc(Br)cc2)[nH]c2cc(Cl)ccc12.OB(O)c1cccnc1>>COC(=O)Cc1c(C(=O)c2ccc(-c3cccnc3)cc2)[nH]c2cc(Cl)ccc12",
        "output": "899"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.Cc1nnc(-c2c(-c3ccccn3)c(C(C)N)nc3ccc(F)cc23)o1.N#Cc1c(N)ncnc1Cl>>Cc1nnc(-c2c(-c3ccccn3)c(C(C)Nc3ncnc(N)c3C#N)nc3ccc(F)cc23)o1",
        "output": "110"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(c1ccncc1)N1C(=O)c2ccccc2C1=O.CO.NN.O>>CC(N)c1ccncc1",
        "output": "242"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1nn(C)c(-c2cn(C(=O)OC(C)(C)C)c3ccccc23)c1C=O.Cc1nn(C)c(Cl)c1C=O>>Cc1nn(C)c(-c2c[nH]c3ccccc23)c1C=O",
        "output": "848"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)COc1ccc(Cl)cc1Cc1ccc(-c2nc3cc(CO)ccc3[nH]2)o1.ClCCl>>CC(C)COc1ccc(Cl)cc1Cc1ccc(-c2nc3cc(C=O)ccc3[nH]2)o1",
        "output": "179"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COCCOC.Cc1cc(F)ccc1B(O)O.Cn1ncc(Br)c1Nc1ccc(I)cc1.O.O=C([O-])[O-].[Cs+].[Cs+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(F)ccc1-c1ccc(Nc2c(Br)cnn2C)cc1",
        "output": "855"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.C[C@@H](N)c1ccc(Br)cc1.Cc1ccnc(Cl)c1[N+](=O)[O-]>>Cc1ccnc(N[C@H](C)c2ccc(Br)cc2)c1[N+](=O)[O-]",
        "output": "612"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COCCl.N#Cc1ccnc(CO)c1.O>>COCOCc1cc(C#N)ccn1",
        "output": "598"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cn1c2c(c3ccc(Br)cc31)CN(C(=O)OC(C)(C)C)CC2.O=c1cc(-c2ccc(Cl)cn2)cc[nH]1>>Cn1c2c(c3ccc(-n4ccc(-c5ccc(Cl)cn5)cc4=O)cc31)CN(C(=O)OC(C)(C)C)CC2",
        "output": "982"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCC(CCOS(=O)(=O)c1ccc(C)cc1)C(F)(F)F.CCCCO.Cl.O.Oc1ccc(O)cc1.[Na+].[OH-]>>CCCCC(CCOc1ccc(O)cc1)C(F)(F)F",
        "output": "438"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.O=P(Cl)(Cl)Cl.c1ccc(CN2CCCc3ccccc32)cc1>>O=Cc1ccc2c(c1)CCCN2Cc1ccccc1",
        "output": "239"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.C[C@H]1COCCN1c1cc(CS(=O)(=O)C2CCCCC2)nc(-c2ccc(N)cc2)n1.O=C(Cl)Oc1ccccc1.O=C([O-])O.[Na+]>>C[C@H]1COCCN1c1cc(CS(=O)(=O)C2CCCCC2)nc(-c2ccc(NC(=O)Oc3ccccc3)cc2)n1",
        "output": "102"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNC1.C1CCOC1.CCN(CC)CC.ClCc1ccc(Br)c(Cl)c1>>Clc1cc(CN2CCCC2)ccc1Br",
        "output": "156"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.COc1ccc(N(C)c2ccccn2)cc1.ClCCl>>CN(c1ccc(O)cc1)c1ccccn1",
        "output": "402"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CC1(C)[C@H](C(=O)O)C[C@@H]1NC(=O)OCc1ccccc1.CCN(CC)CC.ClCCl.On1nnc2ccccc21>>CC1(C)[C@H](C(=O)N2CCOCC2)C[C@@H]1NC(=O)OCc1ccccc1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.O.O=C(c1ccccc1Nc1nc(Nc2cccc(CCN3CCOCC3)c2)ncc1F)N1CCSCC1.O=S([O-])OO.[K+]>>O=C(c1ccccc1Nc1nc(Nc2cccc(CCN3CCOCC3)c2)ncc1F)N1CCS(=O)(=O)CC1",
        "output": "847"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#Cc1cccc(Nc2ncnc3oc4c(c23)CCNC4)c1.CC(C)N(C)C/C=C/C(=O)O.Cl>>C#Cc1cccc(Nc2ncnc3oc4c(c23)CCN(C(=O)/C=C/CN(C)C(C)C)C4)c1",
        "output": "870"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCN(CCCc1cc(Cl)ccc1Oc1cc(F)c(S(=O)(=O)N(Cc2ccc(OC)cc2OC)c2nccs2)cc1Cl)CC(=O)OC.C1CCOC1.Cl.O.O.[Li+].[OH-]>>C#CCN(CCCc1cc(Cl)ccc1Oc1cc(F)c(S(=O)(=O)N(Cc2ccc(OC)cc2OC)c2nccs2)cc1Cl)CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1CO1.CN(C)C=O.Oc1cc(Cl)c(-c2nnc(-c3cn4cc(C(F)(F)F)cc(Cl)c4n3)o2)cc1Cl>>CC(O)COc1cc(Cl)c(-c2nnc(-c3cn4cc(C(F)(F)F)cc(Cl)c4n3)o2)cc1Cl",
        "output": "277"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CN(C)C=O.Cc1ccc(S(=O)(=O)OCC2CCCC2)cc1.O.O=C([O-])[O-].O=Cc1cc(Cl)ccc1O.[K+].[K+]>>O=Cc1cc(Cl)ccc1OCC1CCCC1",
        "output": "438"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)Cc1ccc(C(C)C(=O)O)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)Cc1ccc(C(C)CO)cc1",
        "output": "231"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)[C@H]1C[C@H](C#N)C1.ClCCl.NCCN.O=C(O)C(F)(F)F>>CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)[C@H]1C[C@H](C#N)C1",
        "output": "981"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Nc1cc([N+](=O)[O-])ccc1Br.O.O=C(Cl)c1ccccc1.[Na+].[OH-]>>O=C(Nc1cc([N+](=O)[O-])ccc1Br)c1ccccc1",
        "output": "11"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CCOc1ccc(-c2nc(CCC(=O)c3ccccc3C(=O)O)cs2)cc1OCC.CI.CN(C)C=O.O.O=C([O-])O.[Na+]>>CCOc1ccc(-c2nc(CCC(=O)c3ccccc3C(=O)OC)cs2)cc1OCC",
        "output": "415"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccccc1.C#CCCCC(=O)O.CN(C)C=O.O=C([O-])[O-].[Cs+].[Cs+]>>C#CCCCC(=O)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCC.COC(=O)[C@@](N)(Cc1ccc(-c2ccccc2OC)cc1)C(=O)OC(C)(C)C.O.[Na+].[OH-]>>COc1ccccc1-c1ccc(C[C@](N)(C(=O)O)C(=O)OC(C)(C)C)cc1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)CCOC1CCNCC1.O=C(O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F>>CN(C)CCOC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cl.ClCCl.O=Cc1ccc(O)cc1.[Na+]>>Oc1ccc(CN2CCCC2)cc1",
        "output": "567"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCCc1c(-c2ccc(C(=O)NS(=O)(=O)c3ccc4ccccc4c3)cc2C(=O)N2CCc3ccccc3C2)c(C(=O)OCC)nn1-c1ccccc1.[BH4-].[Li+]>>CCCCc1c(-c2ccc(C(=O)NS(=O)(=O)c3ccc4ccccc4c3)cc2C(=O)N2CCc3ccccc3C2)c(CO)nn1-c1ccccc1",
        "output": "391"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(CNc2c(OCCSc3ccccc3Cl)n[nH]c(=O)c2Br)cc1OC.ClCCl.O=C(OO)c1cccc(Cl)c1.O=S([O-])([O-])=S.[Na+].[Na+]>>COc1ccc(CNc2c(OCCS(=O)c3ccccc3Cl)n[nH]c(=O)c2Br)cc1OC",
        "output": "500"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C=O.FCCBr.O=C(Nc1c[nH]nc1-c1nc2c([nH]1)CCNC2)c1c(F)cccc1F>>O=C(Nc1c[nH]nc1-c1nc2c([nH]1)CCN(CCF)C2)c1c(F)cccc1F",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Nc1cc(Cl)nc(Cl)c1[N+](=O)[O-].CCO.O.[Fe]>>CC(C)(C)OC(=O)Nc1cc(Cl)nc(Cl)c1N",
        "output": "269"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.NC12CC3CC1CC(c1ccc([N+](=O)[O-])cc1)(C3)C2.O.O=C(Cl)OCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>O=C(NC12CC3CC1CC(c1ccc([N+](=O)[O-])cc1)(C3)C2)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COCCn1cc(C(=O)O)c2c(Cl)ccc(Cl)c21.Cl.O=C(NCc1ccc(F)c(C2CCNCC2)c1)C(F)(F)F>>COCCn1cc(C(=O)N2CCC(c3cc(CNC(=O)C(F)(F)F)ccc3F)CC2)c2c(Cl)ccc(Cl)c21",
        "output": "256"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].CC1(C)C(=O)Nc2ccccc21.O=C([O-])[O-].[Na+].[Na+].[Na+]>>CC1(C)C(=O)Nc2ccc(Br)cc21",
        "output": "98"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.ClC(N1CCCC1)=[N+]1CCCC1.F[P-](F)(F)(F)(F)F.Nc1ccc2c(n1)CC1(C2)C(=O)Nc2ncccc21.O=C(O)Cn1c(=O)n(-c2ccccn2)c2ccccc21>>O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(n1)CC1(C2)C(=O)Nc2ncccc21",
        "output": "368"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCCOC.ClCCl.Cl[Pd]Cl.Nc1c([N+](=O)[O-])cc(Br)cc1C(F)(F)F.O=C([O-])[O-].OB(O)c1ccccc1F.[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Nc1c([N+](=O)[O-])cc(-c2ccccc2F)cc1C(F)(F)F",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)c1cc(-c2ccc(C)cc2)c2c(c1)C(C)(C)CCC2(C)C.O=Cc1ccc(C(=O)O)cc1.[K+].[OH-]>>Cc1ccc(-c2cc(C(=O)/C=C/c3ccc(C(=O)O)cc3)cc3c2C(C)(C)CCC3(C)C)cc1",
        "output": "656"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](CNC(=O)c2cc(Cl)nc3ccccc23)CC1.CN(C)CCOC1CCNCC1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C([O-])[O-].[K+].[K+].c1ccncc1>>CN(C)CCOC1CCN(c2cc(C(=O)NC[C@@H]3CC[C@@H](CNC(=O)OC(C)(C)C)CC3)c3ccccc3n2)CC1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(CO)CCO.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.O=C(Cl)c1ccccc1>>CC(C)(CO)CCOC(=O)c1ccccc1",
        "output": "51"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)CCCC(C)CCOc1ccc(C(=O)O)cc1.ClC(Cl)Cl.O=S(Cl)Cl>>CC(C)CCCC(C)CCOc1ccc(C(=O)Cl)cc1",
        "output": "3"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)C1Cc2cc(-c3cc(NCCc4ccc(Cl)cc4Cl)nc(OC)n3)ccc2N1C.CO.O.O.O.[Li+].[OH-]>>COc1nc(NCCc2ccc(Cl)cc2Cl)cc(-c2ccc3c(c2)CC(C(=O)O)N3C)n1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cl.N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1.O=C(O)CN1CCC(N2CCOCC2)CC1>>O=C(CN1CCC(N2CCOCC2)CC1)N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1",
        "output": "133"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.Nc1cccc(F)c1.O.O=C1CCC(=O)N1Cl>>Nc1ccc(Cl)c(F)c1",
        "output": "121"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.O.O=C([O-])[O-].O=C1c2ccccc2C(=O)N1CCCBr.OC1CCNCC1.[K+].[K+]>>O=C1c2ccccc2C(=O)N1CCCN1CCC(O)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Nc1nnc(-c2c(F)cc(Br)cc2F)s1.OCc1ccccc1.[H-].[Na+]>>Nc1nnc(-c2c(F)cc(Br)cc2OCc2ccccc2)s1",
        "output": "485"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.CSCC1Cc2ccc(Cl)nc2-c2cc3c(F)cccc3n21.O.O=S([O-])OO.[K+]>>CS(=O)(=O)CC1Cc2ccc(Cl)nc2-c2cc3c(F)cccc3n21",
        "output": "847"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#C[Si](C)(C)C.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=C1Cc2cc(I)ccc2N1.[Cu]I>>C[Si](C)(C)C#Cc1ccc2c(c1)CC(=O)N2",
        "output": "826"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C)C=O.COc1cc2ncnc(Cl)c2cc1OC.Nc1ccc(F)c(O)c1.O=C([O-])[O-].[Cs+].[Cs+]>>COc1cc2ncnc(Oc3cc(N)ccc3F)c2cc1OC",
        "output": "890"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)OB(c2cnc(N)nc2)OC1(C)C.Clc1nc(NCC(c2ccccc2)N2CCOCC2)c2ccccc2n1.c1ccc(C(CNc2nc(-c3ccc4nccn4c3)nc3ccccc23)c2ccc[nH]2)cc1>>Nc1ncc(-c2nc(NCC(c3ccccc3)N3CCOCC3)c3ccccc3n2)cn1",
        "output": "973"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Nc1ccc(O)cc1.N#Cc1ccc(N(CCCO)CC2CC2)cc1C(F)(F)F>>CC(=O)Nc1ccc(OCCCN(CC2CC2)c2ccc(C#N)c(C(F)(F)F)c2)cc1",
        "output": "478"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cl.Clc1ccc2[nH]ccc2c1.O.O=C1CCNCC1.[K+].[OH-]>>Clc1ccc2[nH]cc(C3=CCNCC3)c2c1",
        "output": "607"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1c2n(c3c(Br)cc(Cl)cc13)CCNC2=O.OB(O)c1ccc(F)c(F)c1F>>Cc1c2n(c3c(-c4ccc(F)c(F)c4F)cc(Cl)cc13)CCNC2=O",
        "output": "833"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOc1ccc(CO)c(Oc2ccc(Cl)cc2Cl)n1.Cc1ccccc1.[Mn+4].[O-2].[O-2]>>CCOc1ccc(C=O)c(Oc2ccc(Cl)cc2Cl)n1",
        "output": "520"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CBr.CCc1c(O)ccc(C(C)=O)c1O>>CCOC(=O)COc1ccc(C(C)=O)c(O)c1CC",
        "output": "123"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(C)=O.Cc1c(C)c(S(=O)(=O)/N=C(\\N)NCCC[C@H](N)C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c(C)c2c1OC(C)(C)C2.O=S(=O)(Cl)c1ccc2ccccc2c1.[Na+].[OH-]>>Cc1c(C)c(S(=O)(=O)/N=C(\\N)NCCC[C@H](NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c(C)c2c1OC(C)(C)C2",
        "output": "596"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nc1ccc2[nH]cnc2c1.S=C=Nc1cccc2ccccc12>>S=C(Nc1ccc2[nH]cnc2c1)Nc1cccc2ccccc12",
        "output": "474"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CO.O=[N+]([O-])c1ccc(N2CC(O)C2)cn1.[Pd]>>Nc1ccc(N2CC(O)C2)cn1",
        "output": "457"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)CCc1ccc(OCc2cccc(-c3c(C)ccc4ccccc34)c2)cc1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>Cc1ccc2ccccc2c1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.CO.COc1ccccc1C(O)c1ccc(C2=NC(C)(C)CO2)cc1.c1ccncc1>>COc1ccccc1C(OC(C)=O)c1ccc(C2=NC(C)(C)CO2)cc1",
        "output": "254"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC#N.CC(=O)OC(C)=O.CCN(CC)CC.NS(=O)(=O)c1cc2c(s1)S(=O)(=O)CCNC2>>CC(=O)N1CCS(=O)(=O)c2sc(S(N)(=O)=O)cc2C1",
        "output": "369"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.O=C(N[C@@H]1CCOC1)C1CCN(c2cncnc2-c2ccc(F)cc2)CC1.[Cl-].[H-].[NH4+].[Na+].c1ccncc1>>CN(C(=O)C1CCN(c2cncnc2-c2ccc(F)cc2)CC1)[C@@H]1CCOC1",
        "output": "83"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(N)(C#N)CC(F)F.Cl.O.O=C(Cl)OCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>CC(C#N)(CC(F)F)NC(=O)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1ccc(C#N)cc1NC1CCNCC1.Cl.Cl.Cl.O.O=C(O)CNC(=O)c1cc(-c2ccccc2)[nH]n1.On1nnc2ccccc21>>Cc1ccc(C#N)cc1NC1CCN(C(=O)CNC(=O)c2cc(-c3ccccc3)[nH]n2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCC2=NCCCN2CC1.CC(C)(C)OC(=O)N[C@@H](CBr)Cc1cccnc1.CCOC(C)=O.CN(C)C=O.O.O=C(c1ccc(F)cc1)C1CCNCC1>>CC(C)(C)OC(=O)N[C@H](Cc1cccnc1)CN1CCC(C(=O)c2ccc(F)cc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)O.CCOC(=O)/C=C/C(=O)N1CC(c2ccccc2)Oc2ccc(Cl)cc21.Cl.[Na+].[OH-]>>O=C(O)/C=C/C(=O)N1CC(c2ccccc2)Oc2ccc(Cl)cc21",
        "output": "122"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)[C@@H]1C[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)CN1C(=O)OC(C)(C)C.Cc1ccccc1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CC(C)(C)OC(=O)N1C[C@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1CO",
        "output": "430"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(Cl)Cl.CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccc(O)cc1F.O.O=[N+]([O-])O.[Br-]>>Cc1cc([N+](=O)[O-])c(O)cc1F",
        "output": "21"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(CN)CC1.NC(=O)CC[C@H](NC(=O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccccc2)cc1)C(=O)O>>CC(C)(C)OC(=O)N1CCC(CNC(=O)[C@H](CCC(N)=O)NC(=O)c2ccc(S(=O)(=O)Nc3ccccc3Oc3ccccc3)cc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cl.O.O=C1CCCc2cc(O)ccc21.O=Cc1ccc(Cl)cc1>>O=C1C(=Cc2ccc(Cl)cc2)CCc2cc(O)ccc21",
        "output": "85"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Br.Br.Br.CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCNCC4)n[nH]c2c1.N#Cc1ccnc(C(=O)O)c1>>CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3cc(C#N)ccn3)CC4)n[nH]c2c1",
        "output": "605"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCCCC.CCCN1CCC23c4cccc(OC)c4OC2C2CCC3(C1=O)C(CO)C2.CI.[H-].[K+]>>CCCN1CCC23c4cccc(OC)c4OC2C2CCC3(C1=O)C(COC)C2",
        "output": "140"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1ccc([N+](=O)[O-])cc1F.CO.O=[Pt]=O>>CCOC(=O)c1ccc(N)cc1F",
        "output": "772"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1CCCC1=O.COc1cc2c(Cl)ncnc2cc1OCc1ccccc1.Cl.O.Oc1ccccc1.[H-].[Na+]>>COc1cc2c(Oc3ccccc3)ncnc2cc1OCc1ccccc1",
        "output": "668"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCCCc1ccc(O)cc1.ClCCl.II>>CCCCCCCCc1ccc(O)c(I)c1",
        "output": "372"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.N#CCBr.O.O=C([O-])[O-].Oc1ccc(Br)cc1.[K+].[K+]>>N#CCOc1ccc(Br)cc1",
        "output": "802"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)OCCN(C1CCCCC1)C2.Cl.NO.[Na+].[OH-]>>O=C(NO)c1ccc2c(c1)OCCN(C1CCCCC1)C2",
        "output": "988"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)(Oc1ccc(Cl)cc1)C(=O)NCCN.CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCC(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)C(F)(F)F>>CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCC(=O)NCCNC(=O)C(C)(C)Oc1ccc(Cl)cc1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cc1cc([N+](=O)[O-])ccc1OCC(C)(C)O.[Pd]>>Cc1cc(N)ccc1OCC(C)(C)O",
        "output": "202"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)C(=COC(F)F)c1ccccc1C.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)C(=COC(F)F)c1ccccc1CBr",
        "output": "29"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)CC(C)(C)c2cc(C#C[Si](C)(C)C)cc(C3CC3)c2O1.CO.O=C([O-])[O-].[K+].[K+]>>C#Cc1cc(C2CC2)c2c(c1)C(C)(C)CC(C)(C)O2",
        "output": "337"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)C[Al]CC(C)C.COC(=O)c1cc(F)c2nc(Br)sc2c1.Cc1ccccc1>>OCc1cc(F)c2nc(Br)sc2c1",
        "output": "444"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C=CC1(c2ccc(OC)c3c2OCCO3)CCC(=O)CC1.[Na+].[OH-]>>COc1ccc(C2(C=CC(=O)O)CCC(=O)CC2)c2c1OCCO2",
        "output": "122"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CCCCC1.CN(C)C=O.[H-].[Na+].c1cn[nH]c1>>c1cnn(CC2CCCCC2)c1",
        "output": "577"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OCCOc1ccc2c(c1)C(=CCCN1CCC(O)(c3ccc(Cl)cc3)CC1)c1cccnc1CO2.CCO.CCOC(C)=O.O.[OH-]>>OCCOc1ccc2c(c1)C(=CCCN1CCC(O)(c3ccc(Cl)cc3)CC1)c1cccnc1CO2",
        "output": "225"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(C(=O)Nc2ccccc2)nc1.[Na+].[OH-]>>O=C(O)c1ccc(C(=O)Nc2ccccc2)nc1",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.C[Si](C)(C)C#Cc1cnn(COCC[Si](C)(C)C)c1.[F-]>>C#Cc1cnn(COCC[Si](C)(C)C)c1",
        "output": "337"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCC2=NCCCN2CC1.CC#N.CC(C)C(=O)Cl.Cl.NCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O>>CC(C)C(=O)NCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O",
        "output": "206"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)[Si](OS(=O)(=O)C(F)(F)F)(C(C)C)C(C)C.ClCCl.O=C1[C@H](Cc2c(Cl)cc(OCc3ccccc3)cc2Cl)CCN1N1CCC(O)CC1.c1ccncc1>>CC(C)[Si](OC1CCN(N2CC[C@@H](Cc3c(Cl)cc(OCc4ccccc4)cc3Cl)C2=O)CC1)(C(C)C)C(C)C",
        "output": "839"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(C)=O.CCCCN(C)S(=O)(=O)CCCCCCl.[I-].[Na+]>>CCCCN(C)S(=O)(=O)CCCCCI",
        "output": "97"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)CBr.COC(=O)Cc1ccc(O)c([N+](=O)[O-])c1.O.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)COc1ccc(CC(=O)OC)cc1[N+](=O)[O-]",
        "output": "123"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.O=S(Cl)Cl.OCCNc1cc(-c2ccccn2)nc(-c2ccccn2)c1>>ClCCNc1cc(-c2ccccn2)nc(-c2ccccn2)c1",
        "output": "96"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.ClCCl.Nc1ccc(I)cc1>>CC(=O)Nc1ccc(I)cc1",
        "output": "6"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.ClCCl.O.O=S([O-])S(=O)(=O)[O-].O=[N+]([O-])c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(Cl)cc2Cl)cc1.[Na+].[Na+]>>Nc1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(Cl)cc2Cl)cc1",
        "output": "401"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.Cc1c([N+](=O)[O-])ccc(N)c1[N+](=O)[O-].O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[S-2]>>Cc1c([N+](=O)[O-])ccc(N)c1N",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.CCOc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.COC(=O)Cc1cccc(OC)c1O.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CCOc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCOc1c(CC(=O)O)cccc1OC",
        "output": "928"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(O)(CCO)c1ccccc1.CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O>>Cc1ccc(S(=O)(=O)OCCC(C)(O)c2ccccc2)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCc2c(n(CCN=[N+]=[N-])c3ccccc23)CC1.CCO.CCOC(C)=O.[Pd]>>CC(C)(C)OC(=O)N1CCc2c(n(CCN)c3ccccc23)CC1",
        "output": "89"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCOCC1.COC(=O)[C@@H](N)[C@@H](C)O.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)CN1CCOCC1>>COC(=O)[C@@H](NC(=O)CN1CCOCC1)[C@@H](C)O",
        "output": "129"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "B.C1CCOC1.CCOC(C)=O.CO.CSC.O=C(O)Cc1ccc2nsnc2c1>>OCCc1ccc2nsnc2c1",
        "output": "231"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNC1.C1CCOC1.Cc1ccc(S(=O)(=O)OCCOc2ccc3c(c2)c(S(=O)(=O)c2cccc4ccccc24)nn3Cc2ccccc2)cc1>>O=S(=O)(c1cccc2ccccc12)c1nn(Cc2ccccc2)c2ccc(OCCN3CCCC3)cc12",
        "output": "429"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.O=P(Cl)(Cl)Cl.O=c1[nH]cnc2cc(N3CCOCC3)c(F)cc12>>Fc1cc2c(Cl)ncnc2cc1N1CCOCC1",
        "output": "14"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.COCCOC.COc1ccc2c(c1)c(CC(=O)O)c(C)n2-c1ncnc2cc(Cl)ccc12.Oc1ccccc1>>COc1ccc2c(c1)c(CC(=O)Oc1ccccc1)c(C)n2-c1ncnc2cc(Cl)ccc12",
        "output": "108"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)C(C(=O)OCC)C(C)c1ccc(NC(=O)OC(C)(C)C)nc1.ClCCl.[K+].[OH-]>>CCOC(=O)C(C(=O)O)C(C)c1ccc(NC(=O)OC(C)(C)C)nc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CI.CN1CCCC1=O.Cn1ccc(CCC(O)c2ccc3c(c2)CCN(C(=O)OC(C)(C)C)CC3)n1.O.[H-].[Na+]>>COC(CCc1ccn(C)n1)c1ccc2c(c1)CCN(C(=O)OC(C)(C)C)CC2",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.COc1cccc(N=C=O)c1.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>COc1cccc(NC(=O)N2CCN(c3nc(-c4ccccc4)ns3)CC2)c1",
        "output": "323"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)c1cc(Oc2ccccc2)c(NS(C)(=O)=O)cc1O.CCOC(C)=O.CO.COc1ccc(C=O)cc1OC.Cl.O.[Na+].[OH-]>>COc1ccc(C=CC(=O)c2cc(Oc3ccccc3)c(NS(C)(=O)=O)cc2O)cc1OC",
        "output": "295"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCCCCCCBr.CN(C)C=O.O.[H-].[Na+].c1ccc(-c2nc(-c3ccccc3)c(-c3ccccc3)[nH]2)cc1>>BrCCCCCCCCn1c(-c2ccccc2)nc(-c2ccccc2)c1-c1ccccc1",
        "output": "276"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1cccc2cnccc12.CC(C)(C)OC(=O)NCCN.CC(C)(C)P(c1ccccc1-c1ccccc1)C(C)(C)C.CC(C)(C)[O-].CCOC(C)=O.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CC(C)(C)OC(=O)NCCNc1cccc2cnccc12",
        "output": "519"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1ccc(Cl)c(-c2[nH]c(C)nc2C)c1.[Na+].[OH-]>>Cc1nc(C)c(-c2cc(C(=O)O)ccc2Cl)[nH]1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCN(CCCC)C(=O)c1nn(-c2ccc(C(=O)NS(=O)(=O)c3ccc4cccc(OCCN5CCOCC5)c4c3)cc2C(=O)OCC)c(C)c1Cl.CCCCN(CCCC)C(=O)c1nn(-c2ccc(C(=O)NS(=O)(=O)c3ccc4ccccc4c3)cc2C(=O)O)c(C)c1Cl>>CCCCN(CCCC)C(=O)c1nn(-c2ccc(C(=O)NS(=O)(=O)c3ccc4cccc(OCCN5CCOCC5)c4c3)cc2C(=O)O)c(C)c1Cl",
        "output": "5"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CC(=O)O.CCN1CCCC1CN>>CCN1CCCC1CNC(=O)C=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C",
        "output": "549"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)CCCCCBr.Cc1ccc(Nc2cc(O)ccc2[N+](=O)[O-])cc1>>COC(=O)CCCCCOc1ccc([N+](=O)[O-])c(Nc2ccc(C)cc2)c1",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.CCN(C(C)C)C(C)C.ClCCl.NC(=O)c1cnc(Nc2cccc(N3CCNCC3)c2)cc1NC1(c2ccccc2)CC1>>CC(=O)N1CCN(c2cccc(Nc3cc(NC4(c5ccccc5)CC4)c(C(N)=O)cn3)c2)CC1",
        "output": "369"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)C1CCc2ccc(OC)cc2C1.[Na+].[OH-]>>COc1ccc2c(c1)CC(C(=O)O)CC2",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "NCCc1ccccc1.O=C(O)c1cc([N+](=O)[O-])c(Sc2c(Cl)cncc2Cl)s1>>O=C(NCCc1ccccc1)c1cc([N+](=O)[O-])c(Sc2c(Cl)cncc2Cl)s1",
        "output": "736"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClC(Cl)Cl.Cn1cc(-c2cc(C(=O)OC(C)(C)C)c(NC(=O)Nc3c(Cl)cccc3Cl)s2)cn1.O=C(O)C(F)(F)F>>Cn1cc(-c2cc(C(=O)O)c(NC(=O)Nc3c(Cl)cccc3Cl)s2)cn1",
        "output": "569"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC[SiH](CC)CC.CSc1ccc(C(=O)CCC(=O)O)cc1.O=C(O)C(F)(F)F.[H-]>>CSc1ccc(CCCC(=O)O)cc1",
        "output": "92"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N1CCC(c2ccc(N)cc2)CC1.ClCCl.O=C1CCC(=O)N1Br>>CC(=O)N1CCC(c2ccc(N)c(Br)c2)CC1",
        "output": "4"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc(OC2CCN(C)CC2)c2c(Cl)ncnc2c1.Nc1cccc(Cl)c1>>COc1cc(OC2CCN(C)CC2)c2c(Nc3cccc(Cl)c3)ncnc2c1",
        "output": "161"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)OC(=O)Cl.CCN(CC)CC.CS(=O)(=O)c1ccc(OCc2csc(C3CCNCC3)n2)cc1.Cl>>CC(C)OC(=O)N1CCC(c2nc(COc3ccc(S(C)(=O)=O)cc3)cs2)CC1",
        "output": "219"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(CC)CC.COc1c2c(c(OC)c(OC)c1OC)CC(CCCCCCCCO)C2.CS(=O)(=O)Cl.O=C([O-])O.[Na+]>>COc1c2c(c(OC)c(OC)c1OC)CC(CCCCCCCCOS(C)(=O)=O)C2",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CC(C)(O)C1CCN(c2nc(C)ccc2[N+](=O)[O-])CC1.Cc1cccc(Br)n1>>Cc1cccc(C#CC(C)(O)C2CCN(c3nc(C)ccc3[N+](=O)[O-])CC2)n1",
        "output": "777"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCC(C)(C)Cc1cn(S(=O)(=O)N(C)C)c(CCC(=O)OC)n1.CO.O.O.[Li+].[OH-]>>CCC(C)(C)Cc1cn(S(=O)(=O)N(C)C)c(CCC(=O)O)n1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COCc1cc([N+](=O)[O-])c(Cl)cc1C(=O)OC.O.[Na+].[OH-]>>COCc1cc([N+](=O)[O-])c(Cl)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1ccc(/C=C/C(=O)Nc2cccc(OCCN3C(=O)c4ccccc4C3=O)c2)cc1.CCO.NN>>CC(C)(C)c1ccc(/C=C/C(=O)Nc2cccc(OCCN)c2)cc1",
        "output": "242"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCC2=NCCCN2CC1.CC#N.C[C@H]1CNC[C@H]1NC(=O)OC(C)(C)C.O=C(O)c1cn(CCF)c2c(F)c(F)c(F)cc2c1=O>>C[C@H]1CN(c2c(F)cc3c(=O)c(C(=O)O)cn(CCF)c3c2F)C[C@H]1NC(=O)OC(C)(C)C",
        "output": "676"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccnc(Cl)n1.Cc1nc(C#Cc2cccc(C#N)c2)c[nH]1>>Cc1ccnc(-n2cc(C#Cc3cccc(C#N)c3)nc2C)n1",
        "output": "788"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCCCCCCCCCNc1ccc(C=O)c(F)c1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.OCCO>>CCCCCCCCCCCCCCCCNc1ccc(C2OCCO2)c(F)c1",
        "output": "117"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.N#Cc1ccc(OCCN2CCOCC2)cc1.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[Li+].[NH4+]>>NCc1ccc(OCCN2CCOCC2)cc1",
        "output": "175"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Cc1cc(Br)ccc1Sc1ccc(C=O)c(C)n1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[C-]#N.[C-]#N.[Fe+2].[Pd].[Pd].[Zn+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cc(C#N)ccc1Sc1ccc(C=O)c(C)n1",
        "output": "65"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.Cn1nc(-c2ccccc2Oc2ccccc2)c(-c2ccc(CN3CCN(C(=O)OC(C)(C)C)CC3)cc2)cc1=O.O=C(O)C(F)(F)F>>Cn1nc(-c2ccccc2Oc2ccccc2)c(-c2ccc(CN3CCNCC3)cc2)cc1=O",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[O-].CN(C)C=O.COc1ccc(O)cc1.Cc1cc(F)ccc1[N+](=O)[O-].Cl.O.[K+]>>COc1ccc(Oc2ccc([N+](=O)[O-])c(C)c2)cc1",
        "output": "564"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)C1CCN(C(=O)OCC(Cl)(Cl)Cl)CC1.O.[K+].[OH-]>>O=C(O)C1CCN(C(=O)OCC(Cl)(Cl)Cl)CC1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C=C(C(=O)O)N(CC)S(=O)(=O)c1ccc(Cl)cc1.CCOC(=O)OC(=O)OCC.NCc1ccnc(-c2ccc(OC(F)(F)F)cc2)c1>>C=C(C(=O)NCc1ccnc(-c2ccc(OC(F)(F)F)cc2)c1)N(CC)S(=O)(=O)c1ccc(Cl)cc1",
        "output": "549"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cc(NS(=O)(=O)c2ccccc2)cc(C)c1SC[N+](=O)[O-].ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.[Na+]>>Cc1cc(NS(=O)(=O)c2ccccc2)cc(C)c1S(=O)C[N+](=O)[O-]",
        "output": "500"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.CCOc1ccc(O)c(C(=O)O)c1C.Cc1cc(C)c(CNCCO)c(OCc2ccccc2)n1.O=C(n1ccnc1)n1ccnc1.[Na+].[OH-]>>CCOc1ccc(O)c(C(=O)N(CCO)Cc2c(C)cc(C)nc2OCc2ccccc2)c1C",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)C=O.CS(=O)(=O)c1ccc([C@@H](CC2CCCC2=O)C(=O)O)cc1Cl.ClCCl.Nc1cnccn1.O=C(Cl)C(=O)Cl.c1ccncc1>>CS(=O)(=O)c1ccc([C@@H](CC2CCCC2=O)C(=O)Nc2cnccn2)cc1Cl",
        "output": "692"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)C[C@@]1(O)CCC[C@H](Nc2nc(-c3c[nH]c4ncc(Cl)cc34)ncc2F)C1>>CNC(=O)C[C@@]1(O)CCC[C@H](Nc2nc(-c3c[nH]c4ncc(Cl)cc34)ncc2F)C1",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C(Nc1ncc(C=O)s1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CC(C)C(Nc1ncc(C=O)s1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)n1nc(CCC=O)cc1-c1ccc(F)cc1.CCN(C(C)C)C(C)C.Cc1ccc(N2CCNCC2)c(C)c1.[Na+]>>Cc1ccc(N2CCN(CCCc3cc(-c4ccc(F)cc4)n(C(C)(C)C)n3)CC2)c(C)c1",
        "output": "484"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](N)C1.O=C1CCCCC1>>CC(C)(C)OC(=O)N1CC[C@H](NC2CCCCC2)C1",
        "output": "236"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.ClCCl.Nc1ccc(Br)cc1F.O=C(Cl)c1ccccc1.O=C([O-])O.[Na+]>>O=C(Nc1ccc(Br)cc1F)c1ccccc1",
        "output": "11"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.O=C1CCCN1CCO>>CS(=O)(=O)OCCN1CCCC1=O",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1CCCC1=O.Cl.O.O=C(O)C1CCNCC1.O=[N+]([O-])c1cc(F)ccc1F>>O=C(O)C1CCN(c2ccc(F)cc2[N+](=O)[O-])CC1",
        "output": "26"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.Cc1nc2cccc3n(CCCCCCN)c(=O)c1n23.ClCCl.O=S(=O)(Cl)CC(F)(F)F>>Cc1nc2cccc3n(CCCCCCNS(=O)(=O)CC(F)(F)F)c(=O)c1n23",
        "output": "493"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(C)c1cccc(C=O)c1O.O=C1CCC(=O)N1Br>>CC(C)c1cc(Br)cc(C=O)c1O",
        "output": "4"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCOS(C)(=O)=O.CCOC(C)=O.CS(C)=O.O.O=C([O-])[O-].O=c1c(N2CCNCC2)nccn1CCOc1cc(F)c(F)cc1F.[K+].[K+]>>CCCCN1CCN(c2nccn(CCOc3cc(F)c(F)cc3F)c2=O)CC1",
        "output": "496"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.O=C(CCCl)N1Cc2ccccc2Cc2ccccc21.O=S(=O)(O)O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>ClCCCN1Cc2ccccc2Cc2ccccc21",
        "output": "533"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCOC(C)=O.COc1ccc(-c2nn(C3CCCCO3)c3ccc(C#N)cc23)cc1.Cl.O>>COc1ccc(-c2n[nH]c3ccc(C#N)cc23)cc1",
        "output": "689"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Nc1cc(C#N)ccc1C(F)(F)F.[Ni]>>CC(C)(C)OC(=O)Nc1cc(CN)ccc1C(F)(F)F",
        "output": "175"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(C)Cn1c(-c2c(F)cc(O)cc2F)c(Cl)nc(-n2cccn2)c1=O.CN(C)C=O.CN(C)CCCl.Cl.O=C([O-])[O-].[Cs+].[Cs+]>>CCC(C)Cn1c(-c2c(F)cc(OCCN(C)C)cc2F)c(Cl)nc(-n2cccn2)c1=O",
        "output": "74"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(CC)CC.CCOP(=O)(OCC)C(C)(C)N.O=C(Cl)c1cccc([N+](=O)[O-])c1>>CCOP(=O)(OCC)C(C)(C)NC(=O)c1cccc([N+](=O)[O-])c1",
        "output": "271"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.CC1(C)c2ccccc2-c2ccc(-c3ccc4cc(Br)ccc4c3)cc21.CCCCCC.Cl.ClCCl.[Li]CCCC>>CC1(C)c2ccccc2-c2ccc(-c3ccc4cc(B(O)O)ccc4c3)cc21",
        "output": "832"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.C1NCC12COC2.C1NCC12COC2.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(O)C(=O)O.O=C([O-])[O-].O=[N+]([O-])c1cccc(Br)c1.[Cs+].[Cs+].[Pd]>>O=[N+]([O-])c1cccc(N2CC3(COC3)C2)c1",
        "output": "294"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.N#Cc1c(CBr)cccc1[N+](=O)[O-].O.O=C([O-])[O-].Oc1ccccc1I.[K+].[K+].c1ccncc1>>N#Cc1c(COc2ccccc2I)cccc1[N+](=O)[O-]",
        "output": "127"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCOC(=O)Cc1ccc(Br)cc1[N+](=O)[O-].CN(C)CC(=O)O.I[Cu]I.O.O=C([O-])[O-].O=[N+]([O-])c1cccc(O)c1.[Cs+].[Cs+]>>CCOC(=O)Cc1ccc(Oc2cccc([N+](=O)[O-])c2)cc1[N+](=O)[O-]",
        "output": "238"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CCOC(C)=O.CS(=O)(=O)Cl.C[Si](C)(C)C(C(N)=O)[Si](C)(C)C.N[C@@H]1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(Sc3cnns3)CS[C@H]12.Nc1nc(/C(=N/OC(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)O)cs1.O=C([O-])[O-].[K+].[K+]>>Nc1nc(/C(=N/OC(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)N[C@@H]2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(Sc4cnns4)CS[C@H]23)cs1",
        "output": "587"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C(=O)Cl)(c1ccccc1)c1ccccc1.CCCCCN>>CCCCCNC(=O)C(C)(c1ccccc1)c1ccccc1",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COCCOC.Cc1cc(N)ccc1Br.O.O=C(O)c1ccc(B(O)O)cc1.O=C([O-])[O-].[Na+].[Na+]>>Cc1cc(N)ccc1-c1ccc(C(=O)O)cc1",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)CCC(=O)Nc2cc(N)ccc21.COc1cc(N2CCOCC2)ccc1Nc1nc(Cl)ncc1Cl>>COc1cc(N2CCOCC2)ccc1Nc1nc(Nc2ccc3c(c2)NC(=O)CCC3(C)C)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=C(O)Cc1cccc(Cl)c1.O=S(=O)(O)O>>COC(=O)Cc1cccc(Cl)c1",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)O.N#Cc1ccc(Oc2ccc3c(c2)CCC3=O)cc1.[K+].[OH-]>>NC(=O)c1ccc(Oc2ccc3c(c2)CCC3=O)cc1",
        "output": "419"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=CC(C)O)c1ccccc1-c1ccccc1.CCO.[H][H].[Pd]>>CC(O)CC(C)c1ccccc1-c1ccccc1",
        "output": "249"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)c1ccc(OC2CCCCO2)cc1.CCO.CO.O=Cc1cccc(Cl)c1Cl.[Na+].[OH-]>>O=C(C=Cc1cccc(Cl)c1Cl)c1ccc(OC2CCCCO2)cc1",
        "output": "295"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CCC(C)(C)c1ccc(C=O)cc1.CCC=O.CO.[K+].[OH-]>>CCC(C)(C)c1ccc(C=C(C)C=O)cc1",
        "output": "85"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCC[N+](CCC)(CCC)CCC.CCOc1cc(CO)ccc1-c1ccc(F)cc1.C[N+]1([O-])CCOCC1.O=[Ru](=O)(=O)[O-]>>CCOc1cc(C=O)ccc1-c1ccc(F)cc1",
        "output": "179"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC2=NCCCN2CC1.CN(C)C=O.Cc1cc(F)ccc1Nc1c(C(=O)N2CCC(c3ccccc3)CC2)cnc2c(S(N)(=O)=O)cnn12.O=C(O)C1CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C(n1ccnc1)n1ccnc1>>Cc1cc(F)ccc1Nc1c(C(=O)N2CCC(c3ccccc3)CC2)cnc2c(S(=O)(=O)NC(=O)C3CC3)cnn12",
        "output": "801"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CCNCC12CC2.Cc1c(-c2cnn(-c3ccc(C(=O)O)cn3)c2O)ccc(C#N)c1F>>Cc1c(-c2cnn(-c3ccc(C(=O)N4CCN(C)C5(CC5)C4)cn3)c2O)ccc(C#N)c1F",
        "output": "256"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCC2=NCCCN2CC1.C1CCOC1.CS(N)(=O)=O.O=C(CCCNC(=O)c1ccc(Nc2nc(NC3(c4ccc(Cl)cc4)CC3)nc(OCC(F)(F)F)n2)cc1)N[C@]1(C(=O)O)C[C@H]1C1CC1.O=C(n1ccnc1)n1ccnc1>>CS(=O)(=O)NC(=O)[C@@]1(NC(=O)CCCNC(=O)c2ccc(Nc3nc(NC4(c5ccc(Cl)cc5)CC4)nc(OCC(F)(F)F)n3)cc2)C[C@H]1C1CC1",
        "output": "644"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)O.CCOC(C)=O.COC(=O)CC[C@H]1C(=O)N(c2ccc(F)cc2)[C@@H]1c1ccc(OCc2ccc(Br)cc2)cc1.Cl.[K+].[OH-]>>O=C(O)CC[C@H]1C(=O)N(c2ccc(F)cc2)[C@@H]1c1ccc(OCc2ccc(Br)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(C)n1-c1cccc(Br)n1.OB(O)c1ccc(OCc2ccccc2)cc1C1CCC1>>Cc1ccc(C)n1-c1cccc(-c2ccc(OCc3ccccc3)cc2C2CCC2)n1",
        "output": "869"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.Cl.NCC1(C(=O)O)CCOCC1.[Na+].[OH-]>>Cc1ccc(S(=O)(=O)NCC2(C(=O)O)CCOCC2)cc1",
        "output": "43"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1ncc(-c2ccc(C(=O)NS(C)(=O)=O)cc2OC)cc1Cl.[BH4-].[Na+]>>COc1cc(C(=O)NS(C)(=O)=O)ccc1-c1cnc(CO)c(Cl)c1",
        "output": "546"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COC(=O)c1cc(O)cc2c1CC(c1ccc(O)cc1)C1CCCC21.[Na+].[OH-]>>O=C(O)c1cc(O)cc2c1CC(c1ccc(O)cc1)C1CCCC21",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCN(CC)CC.COc1ccc(S(=O)(=O)Cl)cc1.COc1ccc(S(=O)(=O)Cl)cc1.COc1ccccc1[C@@H]1OP(=O)([O-])OCC1(C)C.C[C@H]([NH3+])c1cc(F)ccc1-c1ccccc1F>>COc1ccc(S(=O)(=O)N[C@@H](C)c2cc(F)ccc2-c2ccccc2F)cc1",
        "output": "530"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.O.O=C1CCNCC1.O=S(=O)(Cl)c1cccc2nsnc12>>O=C1CCN(S(=O)(=O)c2cccc3nsnc23)CC1",
        "output": "169"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1sc2c(Br)c3ccccc3c(-c3cc(C(C)C)c(O)c(C(C)C)c3)c2c1C.O=C(O)c1ccc(S(=O)(=O)Cl)cc1O>>Cc1sc2c(Br)c3ccccc3c(-c3cc(C(C)C)c(OS(=O)(=O)c4ccc(C(=O)O)c(O)c4)c(C(C)C)c3)c2c1C",
        "output": "380"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)c1cnc(NC(=O)C(CC2CCCC2)c2ccc(S(C)(=O)=O)cc2)s1.O.[Li+].[OH-]>>CS(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)Nc2ncc(C(=O)O)s2)cc1",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](CO)C2)c(Br)c1.OB(O)c1cccnc1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](CO)C2)c(-c2cccnc2)c1",
        "output": "883"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccccc1.Cc1nc(Cl)c([N+](=O)[O-])c(NCCOc2ccccc2)c1C.[H][H].[Pt]>>Cc1nc(Cl)c(N)c(NCCOc2ccccc2)c1C",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.NS(=O)(=O)c1ccc(N2CCNCC2)cc1.O=Cc1ccc2c(c1)NC(=O)CO2.[Na+]>>NS(=O)(=O)c1ccc(N2CCN(Cc3ccc4c(c3)NC(=O)CO4)CC2)cc1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)OC(=O)OCOC(=O)[C@H](OCc1ccccc1)C(C)(C)COS(=O)(=O)CCCCl.CS(C)=O.[N-]=[N+]=[N-].[Na+]>>CC(C)OC(=O)OCOC(=O)[C@H](OCc1ccccc1)C(C)(C)COS(=O)(=O)CCCN=[N+]=[N-]",
        "output": "243"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C[AlH]CC(C)C.CCC(Cc1ccc(OCCc2ccc(S(C)(=O)=O)cc2)cc1)C(=O)OC.ClCCl>>CCC(CO)Cc1ccc(OCCc2ccc(S(C)(=O)=O)cc2)cc1",
        "output": "343"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)[C@@H]1CCCC[C@@H]1N.COc1ccc(C[C@H]2NC(=O)n3c2nc2ccccc23)cc1>>CCOC(=O)[C@@H]1CCCC[C@@H]1NC(=O)N[C@H](Cc1ccc(OC)cc1)c1nc2ccccc2[nH]1",
        "output": "999"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Cn1nnc(-c2cccc([N+](=O)[O-])c2)n1.[Pd]>>Cn1nnc(-c2cccc(N)c2)n1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.N.N#Cc1ccc(-c2cc(C(=O)N3CCC(F)(F)CC3)nn2-c2ccccc2)nc1.[H][H]>>NCc1ccc(-c2cc(C(=O)N3CCC(F)(F)CC3)nn2-c2ccccc2)nc1",
        "output": "560"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCOc1ccccc1N.O=C1CCC(=O)N1Br>>CCOc1cc(Br)ccc1N",
        "output": "4"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCN.CCN(C(C)C)C(C)C.ClC(Cl)Cl.ClCCl.O.O=C(O)Cc1ccc(Br)cc1.O=S(Cl)Cl>>CCCCCCCNC(=O)Cc1ccc(Br)cc1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC[S-].CN(C)C=O.COc1cccc(-c2cc3ccccn3c2)c1.[Na+]>>Oc1cccc(-c2cc3ccccn3c2)c1",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CI.O=C(CC(c1ccc(Br)cc1)C1CCCC1)c1ccc(=O)[nH]c1.O=C([O-])[O-].[K+].[K+]>>Cn1cc(C(=O)CC(c2ccc(Br)cc2)C2CCCC2)ccc1=O",
        "output": "191"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(Cc1ccc(O)cc1)[N+](=O)[O-].CCOC(=O)CBr.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)COc1ccc(CC(C)(C)[N+](=O)[O-])cc1",
        "output": "123"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCI.CN(C)C=O.O.O=C([O-])[O-].O=c1[nH]c2ccc([N+](=O)[O-])cc2c(=O)n1CC1COC1.[K+].[K+]>>CCn1c(=O)n(CC2COC2)c(=O)c2cc([N+](=O)[O-])ccc21",
        "output": "326"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CCO.O.O=[N+]([O-])c1ccc(N2CCN(Cc3ccccc3)CC2)cc1.[Fe]>>Nc1ccc(N2CCN(Cc3ccccc3)CC2)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)O.CCOC(=O)C1CCN(CCc2cccc(-c3cnc(-c4ccc(OC(C)C)c(C#N)c4)s3)c2CC)CC1.O.[Na+].[OH-]>>CCc1c(CCN2CCC(C(=O)O)CC2)cccc1-c1cnc(-c2ccc(OC(C)C)c(C#N)c2)s1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#C[C@]1(O)CCN(C)C1=O.Cc1cn(-c2ccc3c(c2)c(C(N)=O)nn3-c2cccc(Br)c2)cn1>>Cc1cn(-c2ccc3c(c2)c(C(N)=O)nn3-c2cccc(C#C[C@]3(O)CCN(C)C3=O)c2)cn1",
        "output": "659"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CO.COc1cccc2c1CCC2=O.Cl.NO.[Na+]>>COc1cccc2c1CCC2=NO",
        "output": "212"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1ccc(Br)cc1C(F)(F)F.O=C(NCC1CCOCC1)c1cnc(Cl)nc1C(F)(F)F>>O=C(NCC1CCOCC1)c1cnc(Nc2ccc(Br)cc2C(F)(F)F)nc1C(F)(F)F",
        "output": "808"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.O=C(c1ccc(F)cc1)C1CCNCC1.O=C=NCc1ccc(Cl)cc1Cl>>O=C(c1ccc(F)cc1)C1CCN(C(=O)NCc2ccc(Cl)cc2Cl)CC1",
        "output": "583"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(c1ccc(Cl)cc1)C1CCCCC1.O=[N+]([O-])O>>O=C(c1ccc(Cl)c([N+](=O)[O-])c1)C1CCCCC1",
        "output": "21"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc2nc(Cl)nc(N)c2cc1OC.O=C(C1CCCCC1)N1CCNCC1>>COc1cc2nc(N3CCN(C(=O)C4CCCCC4)CC3)nc(N)c2cc1OC",
        "output": "36"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(=O)C1=C(O)CC(c2c(C)cc(OCc3ccccc3)cc2C)CC1=O.CCOC(C)=O.Cl.[Pd]>>CCC(=O)C1=C(O)CC(c2c(C)cc(O)cc2C)CC1=O",
        "output": "23"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(=O)[C@@H](N)Cc1ccc(-c2c(OC)cc(C#N)cc2OC)cc1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc(Br)c(C(=O)O)c1.Cl.F[P-](F)(F)(F)(F)F>>CCOC(=O)[C@H](Cc1ccc(-c2c(OC)cc(C#N)cc2OC)cc1)NC(=O)c1cc(OC)ccc1Br",
        "output": "709"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(C)C=O.O=Cc1cnc2oc3c(N4CCOCC4)nc(Cl)nc3c2c1.[BH3-]C#N.[Na+].[Na+]>>Clc1nc(N2CCOCC2)c2oc3ncc(CN4CCCCC4)cc3c2n1",
        "output": "757"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCN1.ClCCl.O=C(O)c1ccc2cc[nH]c2c1.O=C(n1ccnc1)n1ccnc1>>O=C(c1ccc2cc[nH]c2c1)N1CCOCC1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C.Cc1cc(Nc2ccccc2[N+](=O)[O-])cc2c1NC(=O)CC2(C)C.[H][H]>>Cc1cc(Nc2ccccc2N)cc2c1NC(=O)CC2(C)C",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CCN(C(C)C)C(C)C.ClCCl.Fc1cccc(CC[C@@H]2CCCN2)c1>>CC(=O)N1CCC[C@H]1CCc1cccc(F)c1",
        "output": "125"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CS(=O)(=O)Cl.N#Cc1cc(F)c(N)cc1F.[Li]CCCC>>CS(=O)(=O)Nc1cc(F)c(C#N)cc1F",
        "output": "194"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCCC(=O)O.CCN=C=NCCCN(C)C.CNc1ccccc1.Cl.ClCCl.On1nnc2ccccc21>>C#CCCC(=O)N(C)c1ccccc1",
        "output": "315"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(Oc1ccc(Oc2ccc(Cl)cc2)cc1)C(=O)O.CCN(CC)CC.CCOC(=O)Cl.CCOC(=O)OC(=O)CCOc1ccc(Oc2ccc(Cl)cc2)cc1.O.[BH4-].[Na+]>>CC(CO)Oc1ccc(Oc2ccc(Cl)cc2)cc1",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.ClCCCCBr.O=C([O-])[O-].O=c1[nH]c(=O)n2c(c1-c1ccccc1)SCCC2.[K+].[K+]>>O=c1c(-c2ccccc2)c2n(c(=O)n1CCCCCl)CCCS2",
        "output": "327"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COc1ccc(NC(=O)c2ccc(-c3ccc(NC(=O)OC(C)(C)C)cc3)cc2)cc1NC(=O)CN1CCOCC1.Cl>>COc1ccc(NC(=O)c2ccc(-c3ccc(N)cc3)cc2)cc1NC(=O)CN1CCOCC1",
        "output": "782"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.NCCN1CCOCC1.O=C(Nc1nc2ccc(Sc3cnc4ccc(-c5ccc(F)cc5)cn34)cc2s1)Oc1ccccc1>>O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3cnc4ccc(-c5ccc(F)cc5)cn34)cc2s1",
        "output": "488"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COc1ccc(CC(C)=O)cc1[N+](=O)[O-].[Pd]>>COc1ccc(CC(C)=O)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COc1ccc(N2CCNCC2)cc1OC.ClCCCBr.O=C([O-])[O-].[K+].[K+]>>COc1ccc(N2CCN(CCCCl)CC2)cc1OC",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1cc(C(F)(F)F)cc(-c2ccccc2C(F)(F)F)n1.O=S(=O)(O)O.O=[N+]([O-])O.[Na+].[OH-]>>Nc1nc(-c2ccccc2C(F)(F)F)cc(C(F)(F)F)c1[N+](=O)[O-]",
        "output": "328"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cl.N#Cc1ccc(CO)cc1.NO.O=C([O-])O.[Na+]>>N=C(NO)c1ccc(CO)cc1",
        "output": "854"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(O)c1ccnc(N)c1.CN(C)C=O.O=[N+]([O-])c1ccc(F)c2ccccc12.[H-].[Na+]>>CC(Oc1ccc([N+](=O)[O-])c2ccccc12)c1ccnc(N)c1",
        "output": "485"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CCCCCOc1c(OC)ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)[nH]c12.CO.[Li+].[OH-]>>COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)[nH]c2c1OCCCCCC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.Cl.F[P-](F)(F)(F)(F)F.Nc1cccc(S(N)(=O)=O)c1.O=C(O)c1cc(C(F)F)ccc1F>>NS(=O)(=O)c1cccc(NC(=O)c2cc(C(F)F)ccc2F)c1",
        "output": "50"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCC1CCCCC1.CN(C)C=O.Clc1cccc2cc[nH]c12.[H-].[Na+]>>Clc1cccc2ccn(CC3CCCCC3)c12",
        "output": "470"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.CCOCC.OCCOCCN1CC2CCC1C2>>CC(=O)OCCOCCN1CC2CCC1C2",
        "output": "254"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COCCOC.Cc1cc2oc(-c3ccccn3)nc2cc1N.O.O=C([O-])[O-].S=C(Cl)Cl.[Ca+2]>>Cc1cc2oc(-c3ccccn3)nc2cc1N=C=S",
        "output": "114"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1nc(-c2cccnc2)c2c(=O)n(Cc3ccccc3)ccc2c1O.C[O-].NCCC(=O)O.[Na+]>>O=C(O)CCNC(=O)c1nc(-c2cccnc2)c2c(=O)n(Cc3ccccc3)ccc2c1O",
        "output": "487"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)C(=O)Cl.CCN(CC)CC.COC(=O)c1ccc2ccn(CCCN)c(=O)c2c1.Cl.ClCCl>>COC(=O)c1ccc2ccn(CCCNC(=O)C(C)(C)C)c(=O)c2c1",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CCOc1cc(OC2CCN(C(=O)OC(C)(C)C)CC2)ccc1C(=O)OC.CO.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>C#CCOc1cc(OC2CCN(C(=O)OC(C)(C)C)CC2)ccc1C(=O)O",
        "output": "222"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CCOCC.CN(C)P(=O)(N(C)C)N(C)C.CO.Cc1cc2c(OCC(O)CNC(C)(C)C)cccc2[nH]1.N.O=C(O)/C=C/C(=O)O.O=C(O)c1ccccc1.O=C(OC(=O)c1ccccc1)c1ccccc1.O=C([O-])/C=C/C(=O)O>>Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1",
        "output": "33"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)CCOc1ccc(N)cc1-c1c(Br)cnn1C.ClCCl.O=C=Nc1ccc(Cl)cc1>>CN(C)CCOc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C",
        "output": "804"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.CN1C(=O)CCc2cc(Br)c(Cl)cc21.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CN1C(=O)CCc2cc(B3OC(C)(C)C(C)(C)O3)c(Cl)cc21",
        "output": "942"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1(c2ccoc2)CC1>>CC(C)(C)OC(=O)NC1(c2ccoc2)CC1",
        "output": "631"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.OC1CCC(O)CC1.c1c[nH]cn1>>CC(C)(C)[Si](OC1CCC(O)CC1)(c1ccccc1)c1ccccc1",
        "output": "602"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cncc(C(=O)O)c1.Cl.N#Cc1ccc(CN)c(O)c1>>Cc1cncc(C(=O)NCc2ccc(C#N)cc2O)c1",
        "output": "790"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=C(Cl)N(C)C.CCN(CC)CC.ClCCl.Cn1ncc(Cl)c1C(=O)O.Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12>>Cn1ncc(Cl)c1C(=O)Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12",
        "output": "844"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(Cl)Cl.CCO.COc1ccc2nccc([C@@H](O)CN3CCC(N)CC3)c2n1.O=Cc1cnc2c(c1)CCC(=O)N2.O=S(=O)([O-])[O-].[BH4-].[Na+].[Na+].[Na+]>>COc1ccc2nccc([C@@H](O)CN3CCC(NCc4cnc5c(c4)CCC(=O)N5)CC3)c2n1",
        "output": "441"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.COC(=O)c1ccc(S(C)(=O)=O)cc1-c1ccccc1.[BH4-].[Ca+2].[Cl-].[Cl-].[Na+]>>CS(=O)(=O)c1ccc(CO)c(-c2ccccc2)c1",
        "output": "444"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O=C(O)c1cccc(N2CCS(=O)(=O)CC2)c1.O=S(=O)(O)O>>COC(=O)c1cccc(N2CCS(=O)(=O)CC2)c1",
        "output": "33"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.Cc1cc(NC(=O)OCC(Cl)(Cl)Cl)sn1.O.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>Cc1cc(NC(=O)N2CCN(c3nc(-c4ccccc4)ns3)CC2)sn1",
        "output": "980"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Cc1ccc(CCl)cc1C.O.[C-]#N.[Na+]>>Cc1ccc(CC#N)cc1C",
        "output": "38"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CNC.O=S1(=O)Nc2c(ccc3c(Cl)ccnc23)-c2ccccc21>>CN(C)c1ccnc2c3c(ccc12)-c1ccccc1S(=O)(=O)N3",
        "output": "398"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1c(I)c(CC)c(I)c(-c2ccc(C(=O)O)c([N+](=O)[O-])c2)c1I.O=S(Cl)Cl>>CCc1c(I)c(CC)c(I)c(-c2ccc(C(=O)Cl)c([N+](=O)[O-])c2)c1I",
        "output": "3"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(=O)(=O)Nc1cccc(C=O)c1.FC(F)(F)c1nnc2ccc(N3CCNCC3)nn12>>CS(=O)(=O)Nc1cccc(CN2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)c1",
        "output": "567"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1cc(Oc2ccc(NC(=O)OCc3ccccc3)c(F)c2)ccn1.Cl.O.[Li+].[OH-]>>O=C(Nc1ccc(Oc2ccnc(C(=O)O)c2)cc1F)OCc1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCC(c2c[nH]c3ccc(N)nc23)CC1.O=C(Cl)c1ccc(C(F)(F)F)cc1F>>CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(C(F)(F)F)cc4F)nc23)CC1",
        "output": "463"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CI.COc1ccc(C(CCO)N2C(=O)c3ccccc3C2=O)cc1OC1CCCC1.Cl.[Cl-].[H-].[NH4+].[Na+]>>COCCC(c1ccc(OC)c(OC2CCCC2)c1)N1C(=O)c2ccccc2C1=O",
        "output": "140"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.CN(C)C=O.CN1CCNCC1.Nc1ccc(C(=O)O)cc1N.O.O.On1nnc2ccccc21>>CN1CCN(C(=O)c2ccc(N)c(N)c2)CC1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOc1nc(Sc2nc(C(=O)OC)cs2)nc2[nH]c(CC)c(Br)c12.CN1CCCC1=O.CO.[Na+].[OH-]>>CCOc1nc(Sc2nc(C(=O)O)cs2)nc2[nH]c(CC)c(Br)c12",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(Cl)ccc1N=c1scc(-c2ccc(F)cc2)n1CCCN(CCO)C(=O)OC(C)(C)C.Cl>>COc1cc(Cl)ccc1N=c1scc(-c2ccc(F)cc2)n1CCCNCCO",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.Nc1ccc(C(=O)O)cc1.c1ccc2c(c1)C[C@@H]1NCCC[C@H]21>>Nc1ccc(C(=O)N2CCC[C@@H]3c4ccccc4C[C@@H]32)cc1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CO.NCCCCCC(=O)O.O=C=O.O=S(Cl)Cl>>COC(=O)CCCCCN",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.O=C1COC2(CCN(c3ccc(OC4CCNCC4)cc3)CC2)CN1C1CCC1>>CC(C)N1CCC(Oc2ccc(N3CCC4(CC3)CN(C3CCC3)C(=O)CO4)cc2)CC1",
        "output": "187"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN[C@H]1CN(C(=O)C2CCN(CC3CC3)CC2)C[C@@H]1c1ccc(Cl)c(Cl)c1.COc1ccc(OC(=O)Cl)cc1>>COc1ccc(OC(=O)N(C)[C@H]2CN(C(=O)C3CCN(CC4CC4)CC3)C[C@@H]2c2ccc(Cl)c(Cl)c2)cc1",
        "output": "219"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccccn1.ClCCl.O=C(Cc1ccccc1)c1ccc2[nH]ncc2c1>>CC(C)(C)OC(=O)n1ncc2cc(C(=O)Cc3ccccc3)ccc21",
        "output": "841"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(O)(CC(=O)O)C(F)(F)F.CO.C[Si](C)(C)C=[N+]=[N-]>>COC(=O)CC(C)(O)C(F)(F)F",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc2c(Cl)nc(Nc3cc(C)[nH]n3)cc2c1.OB(O)c1ccc2ccccc2c1>>COc1ccc2c(-c3ccc4ccccc4c3)nc(Nc3cc(C)[nH]n3)cc2c1",
        "output": "865"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCOC(C)=O.CNS(=O)(=O)c1ccc(B(O)O)cc1.Fc1ccc(Br)cc1I.O=C([O-])[O-].O=S(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+]>>CNS(=O)(=O)c1ccc(-c2cc(Br)ccc2F)cc1",
        "output": "855"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)c1ccccn1.Cl.ClCCl.NS(=O)(=O)CCC1CCC(c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1>>CC(=O)NS(=O)(=O)CCC1CCC(c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1",
        "output": "644"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cl.NCC1COc2ccc(O)cc2O1.O=c1ccoc2cc(OCCCBr)ccc12>>O=c1ccoc2cc(OCCCNCC3COc4ccc(O)cc4O3)ccc12",
        "output": "147"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1cc(C=O)ccc1Cl.Cl.O=C(O)c1ccc(N2CC3(CCNCC3)OC2=O)cc1>>CCc1cc(CN2CCC3(CC2)CN(c2ccc(C(=O)O)cc2)C(=O)O3)ccc1Cl",
        "output": "567"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(OCC(=O)c4ccccc4)C(OC)C3)C(C)C(O[Si](C)(C)C(C)(C)C)CC1=O)C(C)CC2OC.F.c1ccncc1>>CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(OCC(=O)c4ccccc4)C(OC)C3)C(C)C(O)CC1=O)C(C)CC2OC",
        "output": "708"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCN(CC)CC.COC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(Br)sc2c1-c1ccc(Cl)cc1.c1ccc(C2CCNC2)cc1>>COC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(N3CCC(c4ccccc4)C3)sc2c1-c1ccc(Cl)cc1",
        "output": "657"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.COc1ncc(Br)c(C(O)C2CCCC2)c1F>>COc1ncc(Br)c(C(=O)C2CCCC2)c1F",
        "output": "32"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C(=O)Cc1ccccc1Br.Cc1ccccc1C.Nc1c(Cl)cccc1Cl.O.O=C([O-])[O-].[Cu].[I-].[K+].[K+].[Na+]>>CN(C)C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl",
        "output": "405"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CC[C@@H](N)[C@H](c2ccc(Cl)c(Cl)c2)C1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cc1ccc(S(=O)(=O)O)cc1.Cl.O.O=C(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(Cl)c(Cl)c2)C1",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C[Si](C)(C)I.Cc1cc(O)c(C(=O)C=Cc2cccc(NC(=O)OC(C)(C)C)c2)c(=O)n1C.ClC(Cl)Cl>>Cc1cc(O)c(C(=O)C=Cc2cccc(N)c2)c(=O)n1C",
        "output": "782"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1.Cl>>O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#CC(C)(O)c1cccnn1.NC(=O)c1cn2c(n1)-c1cc(Br)c(F)cc1OCC2>>CC(O)(C#Cc1cc2c(cc1F)OCCn1cc(C(N)=O)nc1-2)c1cccnn1",
        "output": "659"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC(CCO)Oc1ccc(CC)cc1C(=O)c1ccccc1.CS(=O)(=O)Cl.ClCCl>>CCCC(CCOS(C)(=O)=O)Oc1ccc(CC)cc1C(=O)c1ccccc1",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CCn1nc(C)c([N+](=O)[O-])c1Cl.CO.O.[Cl-].[NH4+].[Zn]>>C=CCn1nc(C)c(N)c1Cl",
        "output": "628"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1CCCC1=O.Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1N.Clc1cc(NC2CC2)nc(-c2cccnc2)n1>>Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1cc(NC2CC2)nc(-c2cccnc2)n1",
        "output": "161"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.Cl.O=C(Cl)OCc1ccccc1.O=C(O)[C@@H]1CCCCNC1.O=C([O-])O.[Na+]>>O=C(O)[C@@H]1CCCCN(C(=O)OCc2ccccc2)C1",
        "output": "427"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.COC(=O)c1cnc(Cl)nc1C(F)(F)F.Cc1ccc(S(=O)(=O)O)cc1.N[C@@H]1CCOC1>>COC(=O)c1cnc(N[C@@H]2CCOC2)nc1C(F)(F)F",
        "output": "544"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCOC(C)=O.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(C(C)C)C(C)C.CCOC(=O)C[C@H]1COc2cc(Br)ccc2N1.CCOC(C)=O.O=C1COc2ccc(C(=O)O)cc2N1>>CCOC(=O)C[C@H]1COc2cc(Br)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2",
        "output": "873"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.COc1cc(O)cc(O)c1.O=[N+]([O-])O>>COc1cc(O)c([N+](=O)[O-])c(O)c1",
        "output": "21"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CNCCCOc1cc([N+](=O)[O-])ccc1-n1cnc(C)n1.Clc1nc(Cl)c2c(n1)C(c1ccccc1)CC2>>Cc1ncn(-c2ccc([N+](=O)[O-])cc2OCCCN(C)c2nc(Cl)nc3c2CCC3c2ccccc2)n1",
        "output": "296"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.Nc1ccc2ccc(Cl)nc2n1.O.O=C(O)c1ccc(C(F)(F)F)cc1>>O=C(Nc1ccc2ccc(Cl)nc2n1)c1ccc(C(F)(F)F)cc1",
        "output": "744"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(OC)OC.O=C(O)c1cc(O)c(O)c(O)c1.O=S(=O)(O)O>>COC(=O)c1cc(O)c(O)c(O)c1",
        "output": "195"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.O=C(Nc1nc2ccc([N+](=O)[O-])cc2s1)c1ccccc1.[Pd]>>Nc1ccc2nc(NC(=O)c3ccccc3)sc2c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(CCn1cc(-c2cccnn2)c(=O)[nH]c1=O)OC>>O=CCCn1cc(-c2cccnn2)c(=O)[nH]c1=O",
        "output": "234"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)c1ccc(C(=O)O)cc1.N.O.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)c1ccc(C(N)=O)cc1",
        "output": "358"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.COc1ccc2[nH]cc(CCCCOS(=O)(=O)c3ccc(C)cc3)c2c1.O=C([O-])[O-].O=c1ccccn1-c1ccc(N2CCNCC2)cc1.[I-].[K+].[K+].[K+]>>COc1ccc2[nH]cc(CCCCN3CCN(c4ccc(-n5ccccc5=O)cc4)CC3)c2c1",
        "output": "429"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.Cl.ClCCCl.N#Cc1ccc(N(CC(=O)O)CC(F)(F)F)cc1C(F)(F)F.NC(=NO)c1ccccc1>>N#Cc1ccc(N(Cc2nc(-c3ccccc3)no2)CC(F)(F)F)cc1C(F)(F)F",
        "output": "926"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Cc1cccc2cc(C(=O)O)n(Cc3ccc(Cl)cc3)c12.ClCCCl.O=C(NCc1ccccc1)C1CCNCC1.On1nnc2ccccc21>>Cc1cccc2cc(C(=O)N3CCC(C(=O)NCc4ccccc4)CC3)n(Cc3ccc(Cl)cc3)c12",
        "output": "605"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)CCN.CCc1ccc(C=O)s1.Cl.ClCCl.O=C([O-])O.[Na+].[Na+]>>CCc1ccc(CNCCC(=O)OC(C)(C)C)s1",
        "output": "691"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1NCCc2ccc(F)cc21.O=C(O)c1cc2ncc(Cl)cn2n1>>CN1c2cc(F)ccc2CCN1C(=O)c1cc2ncc(Cl)cn2n1",
        "output": "995"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cc1c(CC(=O)O)c(=O)oc2cc(N)ccc12.O=S(=O)(O)O>>COC(=O)Cc1c(C)c2ccc(N)cc2oc1=O",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=O.CC#N.CC(=O)O.N#CC(C#N)=C1NCCN1CCNCc1ccc(CN2CCCCC2)o1.[BH3-]C#N.[Na+]>>CN(CCN1CCNC1=C(C#N)C#N)Cc1ccc(CN2CCCCC2)o1",
        "output": "217"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.Cc1cc(Nc2cnc3c(n2)c(C(=O)NC(C)(C)C)cn3COCC[Si](C)(C)C)[nH]n1.ClCCl.O=C(O)C(F)(F)F.[NH4+].[OH-]>>Cc1cc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)[nH]n1",
        "output": "981"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CC(F)(F)C(=O)N2C.F[P-](F)(F)(F)(F)F.N[C@@H]1CN2CCC1CC2>>COc1cc(C(=O)N[C@@H]2CN3CCC2CC3)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#Cc1ccc(N)nc1N.C1CCOC1.CCN(CC)CC.ON=C(Cl)Cc1ccc(OCc2ccccc2)cc1>>Nc1ccc(-c2cc(Cc3ccc(OCc4ccccc4)cc3)no2)c(N)n1",
        "output": "976"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCCCCC(=O)Cl.CCCCCCCCCCCCCC(=O)NCCN=[N+]=[N-].CCN(CC)CC.ClCCl.[N-]=[N+]=NCCN>>CCCCCCCCCC(=O)NCCN=[N+]=[N-]",
        "output": "45"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccccc1.CN(C)C=O.Cl.O.O=C([O-])[O-].O=C1CCNCC1.[K+].[K+]>>O=C1CCN(Cc2ccccc2)CC1",
        "output": "248"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCc1cc2cc(N)ccc2o1.CS(=O)(=O)Cl>>CCCCc1cc2cc(NS(C)(=O)=O)ccc2o1",
        "output": "194"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(C)=O.COC(=O)C1(CC(=O)c2ccc(Br)cc2)CCCC1.Cc1ccccc1.O=C([O-])[O-].O=[N+]([O-])c1ccc(B(O)O)cc1.[Cl-].[Na+].[Na+].[Na+]>>COC(=O)C1(CC(=O)c2ccc(-c3ccc([N+](=O)[O-])cc3)cc2)CCCC1",
        "output": "837"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CCN(CC)CC.CCOC(C)=O.COc1cc2nccc(Oc3ccc(-n4ccc(C(O)c5ccccc5)cc4=O)cc3F)c2cc1OC.ClCCl.O>>COc1cc2nccc(Oc3ccc(-n4ccc(C(OC(C)=O)c5ccccc5)cc4=O)cc3F)c2cc1OC",
        "output": "126"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)CO1.CCN(CC)CC.CN(C)C=O.Cc1nn(C(C)c2cc(Cl)c(C#N)c3c2OC(C)CN(C2CNC2)C3)c2ncnc(N)c12.Cl.Cl.Cl>>Cc1nn(C(C)c2cc(Cl)c(C#N)c3c2OC(C)CN(C2CN(CC(C)(C)O)C2)C3)c2ncnc(N)c12",
        "output": "76"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC(C)(Oc1ccc(C(=O)c2ccc(Cl)cc2)cc1)C(=O)NCCOCCN.CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCC(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.F[P-](F)(F)(F)(F)F>>CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCC(=O)NCCOCCNC(=O)C(C)(C)Oc1ccc(C(=O)c2ccc(Cl)cc2)cc1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CC(=O)Cl.NCc1nc(-c2ccc(C(=O)Nc3ccccn3)cc2)c2c(N)nccn12>>C=CC(=O)NCc1nc(-c2ccc(C(=O)Nc3ccccn3)cc2)c2c(N)nccn12",
        "output": "298"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CC(O)C(n2ccc3c([N+](=O)[O-])cccc3c2=O)C1.CO.[Pd]>>CC(C)(C)OC(=O)N1CC(O)C(n2ccc3c(N)cccc3c2=O)C1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(=O)Nc1cccc(C2CCN(CCCN)CC2)c1.O=C(O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1>>CCC(=O)Nc1cccc(C2CCN(CCCNC(=O)C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)CC2)c1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)[C@@H](Cc1ccccc1)NC(=O)c1ccc(-c2nn(C)c(C)c2NC(=O)O[C@H](C)c2ccccc2)cc1.Cl.O.[Li+].[OH-]>>Cc1c(NC(=O)O[C@H](C)c2ccccc2)c(-c2ccc(C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)nn1C",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(c1cc(C(=O)O)ncn1)C1CCCCC1.Cc1cc(S(N)(=O)=O)ccc1N>>Cc1cc(S(N)(=O)=O)ccc1NC(=O)c1cc(N(C)C2CCCCC2)ncn1",
        "output": "548"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)OB(c2cnc(N)nc2)OC1(C)C.CN(C)CC(=O)N(C)Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1>>CN(C)CC(=O)N(C)Cc1cc2nc(-c3cnc(N)nc3)nc(N3CCOCC3)c2s1",
        "output": "973"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CC(C)(C)OC(=O)NC1CCC(NC(=O)c2cc(Oc3ccc(C#N)cc3)cc(Oc3ccc(C(=O)O)cc3)c2)CC1.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)NC1CCC(NC(=O)c2cc(Oc3ccc(C#N)cc3)cc(Oc3ccc(C(=O)OCc4ccccc4)cc3)c2)CC1",
        "output": "403"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)c1cc(C(C)(C)C)nn1CCN(C)C.[Li+].[OH-]>>CN(C)CCn1nc(C(C)(C)C)cc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1N.CN(C)c1ccncc1.CN1CCCC1=O.Cc1nc(Nc2cc(Cl)nnc2C(N)=O)ccc1F.N#N>>Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)nnc2C(N)=O)ccc1F",
        "output": "241"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C#N)C1CC(F)(F)C1.CCO.O.[Na+].[OH-]>>CC(C)(C(=O)O)C1CC(F)(F)C1",
        "output": "259"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.NN.O.O.O=C(CCCN1CCCCCC1Cc1ccc(Cl)cc1)c1ccc(F)cc1.OCCOCCOCCO.[K+].[OH-]>>Fc1ccc(CCCCN2CCCCCC2Cc2ccc(Cl)cc2)cc1",
        "output": "92"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ncc(Br)c(C)c1Cl.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cc1c(Br)c[n+]([O-])c(C)c1Cl",
        "output": "262"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(O)c1ccc(Cl)c(F)c1.ClCCl.O>>CC(=O)c1ccc(Cl)c(F)c1",
        "output": "32"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(B3OC(C)(C)C(C)(C)O3)cc12.Fc1cncc2[nH]c(-c3nc(Cl)ccc3OCc3ccccc3)cc12.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc(OCc4ccccc4)c(-c4cc5c(F)cncc5[nH]4)n3)cc12",
        "output": "955"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.Cc1ccccc1-c1cc(N2CCNCC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C([O-])[O-].OCCOCCCl.[K+].[K+].[Na+].[OH-]>>Cc1ccccc1-c1cc(N2CCN(CCOCCO)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCI.O=C([O-])[O-].Oc1c(C2CCNCC2)cccc1C(F)(F)F.[K+].[K+]>>CCN1CCC(c2cccc(C(F)(F)F)c2O)CC1",
        "output": "184"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(F)CN1CCC(COc2ccc(-c3ccc(C(=O)O)cc3F)cc2C#N)CC1.CCN(C(C)C)C(C)C.ClCCCl.ClCCl.O.O[C@@H]1CCCNC1.On1nnc2ccccc21>>CC(C)(F)CN1CCC(COc2ccc(-c3ccc(C(=O)N4CCC[C@@H](O)C4)cc3F)cc2C#N)CC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CCCCCNC.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1ccc2c(O[C@H]3C[C@@H](C(=O)O)N(C(=O)OC(C)(C)C)C3)cc(-c3nc(C(C)C)cs3)nc2c1Cl.Cc1ccc(S(=O)(=O)O)cc1.F[B-](F)(F)F>>C=CCCCCN(C)C(=O)[C@@H]1C[C@H](Oc2cc(-c3nc(C(C)C)cs3)nc3c(Cl)c(OC)ccc23)CN1C(=O)OC(C)(C)C",
        "output": "685"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCN=C=O.CCOC(C)=O.ClCCl.NC[C@H]1CN(c2ccc3c(c2)CCCc2cnoc2-3)C(=O)O1>>CCNC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCc2cnoc2-3)C(=O)O1",
        "output": "244"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CN(C)C=O.O=C1NCCOc2cc([N+](=O)[O-])ccc21.[Pd]>>Nc1ccc2c(c1)OCCNC2=O",
        "output": "28"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CCCOc1c(F)cc(B2OC(C)(C)C(C)(C)O2)cc1F.Clc1cccc(Oc2ccccc2)n1>>CCOC(=O)CCCOc1c(F)cc(-c2cccc(Oc3ccccc3)n2)cc1F",
        "output": "955"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)CCN.CC(Cl)Cl.O=Cc1c(F)cc(Br)cc1F.[K+].[Na+].[OH-]>>CC(C)CCNCc1c(F)cc(Br)cc1F",
        "output": "468"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.Cc1noc(-c2ccc([N+](=O)[O-])cc2)n1.[Fe]>>Cc1noc(-c2ccc(N)cc2)n1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1ccc(OC/C=C(\\C)CCC=C(C)C)cc1O.[K+].[OH-]>>CC(C)=CCC/C(C)=C/COc1ccc(C(=O)O)c(O)c1",
        "output": "222"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Cc1cc([C@H](C)N)ncc1Br.Cl.ClCCl>>Cc1cc([C@H](C)NC(=O)OC(C)(C)C)ncc1Br",
        "output": "631"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCNc1ncc(C(F)(F)F)cc1N.CCN=C=NCCCN(C)C.CCSc1ccccc1C(=O)O.O=C([O-])[O-].[Na+].[Na+].c1ccncc1>>CCCNc1ncc(C(F)(F)F)cc1NC(=O)c1ccccc1SCC",
        "output": "759"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CNCCN1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOCC.CN(C)C=O.CO.ClCCCl.ClCCl.O=CCCCOc1ccc2c(n1)NC(=O)CC2.O=c1[nH]c2cccc(N3CCNCC3)c2o1.[Na+]>>O=C1CCc2ccc(OCCCCN3CCN(c4cccc5[nH]c(=O)oc45)CC3)nc2N1",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CNCCNC.COc1cc(Br)ccc1OCC(C)(C)O.ClCCl.O=P([O-])([O-])[O-].O=c1cc(-c2ccc(C(F)(F)F)cc2)cn[nH]1.[Cu]I.[K+].[K+].[K+]>>COc1cc(-n2ncc(-c3ccc(C(F)(F)F)cc3)cc2=O)ccc1OCC(C)(C)O",
        "output": "919"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(CCCC(=O)O)c2ccccc2-c2[nH]c(=O)c3nccn3c21.CN(C)C=O.CO.ClC(Cl)Cl.N.O=C(Cl)C(=O)Cl>>CC1(CCCC(N)=O)c2ccccc2-c2[nH]c(=O)c3nccn3c21",
        "output": "313"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cnn(-c2nc3cc(Oc4ccccc4)ccc3c(=O)[nH]2)c1.O=P(Cl)(Cl)Cl>>CCOC(=O)c1cnn(-c2nc(Cl)c3ccc(Oc4ccccc4)cc3n2)c1",
        "output": "14"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=O.CO.O=S(=O)(c1ccc(OCC(F)(F)F)c(N2CCNCC2)c1)n1ccc2ccc(F)cc21.[BH3-]C#N.[Na+]>>CN1CCN(c2cc(S(=O)(=O)n3ccc4ccc(F)cc43)ccc2OCC(F)(F)F)CC1",
        "output": "217"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)S(=O)(=O)Cl.NC(=O)c1cc2c(-c3cccc(N)c3)cncc2s1.c1ccncc1>>CN(C)S(=O)(=O)Nc1cccc(-c2cncc3sc(C(N)=O)cc23)c1",
        "output": "395"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCCCCCCOc1ccc(Br)cc1.COB(OC)OC.Cl.[Li]CCCC>>CCCCCCCCOc1ccc(B(O)O)cc1",
        "output": "789"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)c1ccc(C=C(Br)Br)cc1.Cl.ClCCl.[H-]>>OCc1ccc(C=C(Br)Br)cc1",
        "output": "311"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCBr.CC1(C)CC(N2CCCCCC2=O)CC(C)(C)N1.CN(C)C=O.O=C([O-])[O-].[Na+].[Na+]>>C=CCN1C(C)(C)CC(N2CCCCCC2=O)CC1(C)C",
        "output": "252"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.Cc1ccc(C(C)(C)C)cc1C#C[Si](C)(C)C.O=C([O-])[O-].[K+].[K+]>>C#Cc1cc(C(C)(C)C)ccc1C",
        "output": "337"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCCc1cnc(-c2ccc(O)cc2)nc1.CCCCCC[C@H](F)COc1ccc(C(=O)O)cc1>>CCCCCCCCCc1cnc(-c2ccc(OC(=O)c3ccc(OC[C@@H](F)CCCCCC)cc3)cc2)nc1",
        "output": "355"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCO.CN(C)Cc1ccc([N+](=O)[O-])cc1.Cl.[Fe]>>CN(C)Cc1ccc(N)cc1",
        "output": "507"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)CC#Cc1ccc(C(CC2CCCC2)C(=O)O)cc1.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.ClCCl.F[P-](F)(F)(F)(F)F.Nc1nccs1>>CN(C)CC#Cc1ccc(C(CC2CCCC2)C(=O)Nc2nccs2)cc1",
        "output": "681"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.Cc1nc2ccccc2n1CCCl.O=C([O-])[O-].O=[N+]([O-])c1cn[nH]c1.[Cs+].[Cs+]>>Cc1nc2ccccc2n1CCn1cc([N+](=O)[O-])cn1",
        "output": "604"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.COc1ccccc1N1CCNCC1.O=C([O-])[O-].O=C1c2ccccc2C(=O)N1CCCCBr.[K+].[K+]>>COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.[H-].[Na+].c1cnc2[nH]ccc2c1>>Cn1ccc2cccnc21",
        "output": "570"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(CC(=O)O)n1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Nc1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1.On1nnc2ccccc21>>CC(C)(C)OC(=O)Nc1cccc(CC(=O)Nc2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cc2)n1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C=O.COC(=O)c1ccc(-c2nc3cc(C#N)cc(C(C)(C)F)c3o2)cc1.C[Si](C)(C)[O-].ClCCl.NCC1CCN(c2ccc(C(F)(F)F)cn2)CC1.O=C(Cl)C(=O)Cl.[K+]>>CC(C)(F)c1cc(C#N)cc2nc(-c3ccc(C(=O)NCC4CCN(c5ccc(C(F)(F)F)cn5)CC4)cc3)oc12",
        "output": "338"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCC[C@@H](O)C[C@H](C#N)c1ccc(OC)cc1.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.c1ccncc1>>CCCCCC[C@H](C[C@H](C#N)c1ccc(OC)cc1)OS(=O)(=O)c1ccc(C)cc1",
        "output": "197"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.COc1cc(C(C)C(=O)O)ccc1C#N.Cc1cccc(-c2nc(C(F)(F)F)ccc2CN)c1.On1nnc2ccccc21>>COc1cc(C(C)C(=O)NCc2ccc(C(F)(F)F)nc2-c2cccc(C)c2)ccc1C#N",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCCBr.C1CCOC1.CC(C)(C)[Si](C)(C)OCCCc1ccc(Br)cc1.[Mg]>>OCCCc1ccc(Br)cc1",
        "output": "708"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1N.CCN(C(C)C)C(C)C.CN1CCCC1=O.Cc1c[nH]c2c(Nc3nc(Cl)cc4cn[nH]c(=O)c34)cccc12.O>>Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCCC[C@@H]4NC(=O)OC(C)(C)C)cc4cn[nH]c(=O)c34)cccc12",
        "output": "70"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)n1c(C#N)ccc1-c1ccc2c(c1)C(C)(C)OC(=S)N2.CCO.CC[O-].[Na+]>>CC1(C)OC(=S)Nc2ccc(-c3ccc(C#N)[nH]3)cc21",
        "output": "848"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CC(c1oc(=O)c2ccccc2c1-c1cncs1)n1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc21.CN(C)C=O.c1c[nH]cn1>>CC(c1oc(=O)c2ccccc2c1-c1cncs1)n1nc(-c2cc(F)cc(O[Si](C)(C)C(C)(C)C)c2)c2c(N)ncnc21",
        "output": "746"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(O)(CC(=O)[O-])c1ccnc(OC)c1COCc1ccccc1.O=C(O)C(F)(F)F>>CCC(O)(CC(=O)O)c1ccnc(OC)c1COCc1ccccc1",
        "output": "151"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCc1ccc(OCCC(C)C)c2c(=O)cc(-c3nnnn3Cc3ccccc3)oc12.CCO.[Pd]>>CCCc1ccc(OCCC(C)C)c2c(=O)cc(-c3nnnn3Cc3ccccc3)oc12",
        "output": "116"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.Cc1c(N)cccc1F.O=C1CCC(=O)N1Br.O=S([O-])([O-])=S.[Na+].[Na+]>>Cc1c(N)ccc(Br)c1F",
        "output": "4"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC1(CC)c2cc(C(N)=O)ccc2C[C@H](OC)[C@H]1NCC[C@H](CC1CCCCC1)C(=O)OC.CO.[Na+].[OH-]>>CCC1(CC)c2cc(C(N)=O)ccc2C[C@H](OC)[C@H]1NCC[C@H](CC1CCCCC1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNCC1.CCO.Cc1[nH]c(C=O)c(CCC(=O)O)c1S(C)(=O)=O.O=C1Cc2cc(F)ccc2N1>>Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(F)cc32)c(CCC(=O)O)c1S(C)(=O)=O",
        "output": "911"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)O)CC1.CNC(C)C>>CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)N(C)C(C)C)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2ncc(C(=O)N3CCC(c4ccc(F)cc4)CC3)c(Cl)c2Cl)cc1.Nc1cc(F)ccc1Cl>>COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2ncc(C(=O)N3CCC(c4ccc(F)cc4)CC3)c(Nc3cc(F)ccc3Cl)c2Cl)cc1",
        "output": "957"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC1(C)OB(c2ccc(F)nc2)OC1(C)C.Fc1ccc(-n2ncnc2-c2cc3c(s2)-c2nc(Cl)ccc2OCC3)c(F)c1.O.O=C([O-])[O-].[Cs+].[Cs+]>>Fc1ccc(-n2ncnc2-c2cc3c(s2)-c2nc(-c4ccc(F)nc4)ccc2OCC3)c(F)c1",
        "output": "968"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#C[Si](C)(C)C.CCN(CC)CC.Nc1ccc(F)cc1Br.[Cl-].[Cl-].[Cu]I.[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C[Si](C)(C)C#Cc1cc(F)ccc1N",
        "output": "671"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNCC1.CC(=O)O.CCO.O=C1Cc2ccc(Cl)cc2N1.O=Cc1[nH]c2c(c1CCC(=O)O)CCCC2>>O=C(O)CCc1c(C=C2C(=O)Nc3cc(Cl)ccc32)[nH]c2c1CCCC2",
        "output": "440"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)CCc1cn(C)cn1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>Cn1cnc(CCCO)c1",
        "output": "225"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.COC(=O)C1(CCCc2c(F)cnc3ccc(OC)cc23)CN(C/C=C/c2cc(F)ccc2F)C1.Cl.[Na+].[OH-]>>COc1ccc2ncc(F)c(CCCC3(C(=O)O)CN(C/C=C/c4cc(F)ccc4F)C3)c2c1",
        "output": "361"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.CN(C)C=O.Cc1cccc(C=O)c1O.O=C([O-])[O-].[K+].[K+]>>Cc1cccc(C=O)c1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COc1cc(F)ccc1C=O.O.O=C([O-])O.[BH4-].[K+].[Na+]>>COc1cc(F)ccc1CO",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)[O-])CC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1.Cc1ccccc1.O.[Al].[Na+]>>CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1",
        "output": "151"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.Fc1ccc(N2CCNCC2)cc1.O=Cc1cccc(-c2ccccc2)c1.[Na+].c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1>>Fc1ccc(N2CCN(Cc3cccc(-c4ccccc4)c3)CC2)cc1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)O.CCO.COC(=O)C1(c2ccc(-c3ccc(-c4nc(C(N)=O)c(C)nc4C)cc3)c(Cl)c2)CCC1.Cl.[K+].[OH-]>>Cc1nc(C)c(-c2ccc(-c3ccc(C4(C(=O)O)CCC4)cc3Cl)cc2)nc1C(N)=O",
        "output": "203"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCc1cccc(CNC[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)c1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(-c2ncco2)cc1>>CCc1cccc(CNC[C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2ccc(-c3ncco3)cc2)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N=C(N)N(Cc1ccc(OCCCO)c(Br)c1)C(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N=C(N)N(Cc1ccc(OCCCOS(=O)(=O)C(F)(F)F)c(Br)c1)C(=O)OC(C)(C)C",
        "output": "582"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(C)=O.COC(=O)c1cncc(CON2C(C)(C)CCCC2(C)C)c1.[BH4-].[Na+]>>CC1(C)CCCC(C)(C)N1OCc1cncc(CO)c1",
        "output": "522"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)CS(=O)c1cccc(CO)c1.ClCCl>>CC(C)CS(=O)c1cccc(C=O)c1",
        "output": "179"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CC[C@@H](N)[C@H](c2ccccc2)C1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cc1ccc(S(=O)(=O)O)cc1.Cl.O.O=C(O)c1ccc(Cl)cc1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)c2ccc(Cl)cc2)[C@H](c2ccccc2)C1",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N1CCN(c2cccc3cc[nH]c23)CC1.ClCCl.[BH3-]C#N.[Na+].[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCN(c2cccc3c2NCC3)CC1",
        "output": "672"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.O.O=[N+]([O-])c1cccc(F)c1.[H-].[Na+].c1c[nH]cn1>>O=[N+]([O-])c1cccc(-n2ccnc2)c1",
        "output": "701"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)CCO.CCOCC.COc1c(Cl)cc2c(N)nc(Cl)nc2c1OC.O=C(C1CCCO1)N1CCNCC1>>COc1c(Cl)cc2c(N)nc(N3CCN(C(=O)C4CCCO4)CC3)nc2c1OC",
        "output": "36"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCNC3)cc1.COC(=O)Cl>>CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(C(=O)OC)C3)cc1",
        "output": "219"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC[C@@H](NC(=O)OC(C)(C)C)c1ccc(-c2c(OC)ccc3[nH]c(=O)c4sccc4c23)cc1.CN(C)C=O.O=C1CCC(=O)N1Cl>>CC[C@@H](NC(=O)OC(C)(C)C)c1ccc(-c2c(OC)cc(Cl)c3[nH]c(=O)c4sccc4c23)cc1",
        "output": "743"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.CC(C)=O.CC(O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F.CCCCCC.ClCCl.O.O=S(=O)(O)O.O=[Cr](=O)=O>>CC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F",
        "output": "32"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CS(C)=O.Fc1cccc(Br)n1.N#CC1(CN)CCOCC1>>N#CC1(CNc2cccc(Br)n2)CCOCC1",
        "output": "810"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCN(CCCCO)CC2)c1.O=C(Cl)Cc1ccc(F)cc1>>CC(C)C(=O)Nc1cccc(C2CCN(CCCCOC(=O)Cc3ccc(F)cc3)CC2)c1",
        "output": "126"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Br.CC(=O)O.CCCn1c(-c2ccc([N+](=O)[O-])cc2)c(C)c2cc(OCc3ccccc3)ccc21>>CCCn1c(-c2ccc([N+](=O)[O-])cc2)c(C)c2cc(O)ccc21",
        "output": "23"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)S(=O)(=O)CCCN.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.O.O=C(O)C1=Cc2c(ncnc2Nc2ccc(Oc3cccc(C(F)(F)F)c3)c(Cl)c2)NCC1.On1nnc2ccccc21>>CC(C)(C)S(=O)(=O)CCCNC(=O)C1=Cc2c(ncnc2Nc2ccc(Oc3cccc(C(F)(F)F)c3)c(Cl)c2)NCC1",
        "output": "549"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.COC(=O)C(C)c1ccc(F)c(N)c1.Cc1ccc(S(=O)(=O)O)cc1.O.O.O=C([O-])O.O=N[O-].O=S([O-])([O-])=S.[I-].[Na+].[Na+].[Na+].[Na+]>>COC(=O)C(C)c1ccc(F)c(I)c1",
        "output": "200"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.NC[C@H](O)c1cccc(Cl)c1>>CC(C)(C)OC(=O)NC[C@H](O)c1cccc(Cl)c1",
        "output": "631"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1cc(NC(=O)c2ccc(Cl)nc2)ccc1I.Nc1ccc(Cl)c(I)c1.O=C(Cl)c1ccc(Cl)nc1>>O=C(Nc1ccc(Cl)c(I)c1)c1ccc(Cl)nc1",
        "output": "642"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1ccc(Cl)cc1.CCOC(=O)C(=O)OCC.CCOCC.C[Si](C)(C)[N-][Si](C)(C)C.[Li+]>>CCOC(=O)C(=O)CC(=O)c1ccc(Cl)cc1",
        "output": "526"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.COc1cccc([N+](=O)[O-])c1CC(=O)[O-].Cc1ccccc1.Cl.[H-]>>COc1cccc([N+](=O)[O-])c1CCO",
        "output": "231"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1ccc(C(=O)O)cc1.N.[Ni]>>CC(N)c1ccc(C(=O)O)cc1",
        "output": "552"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(C)=O.C[Si](C)(CCCCOc1ccc(-c2ncc(OCc3ccccc3)cn2)cc1)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.[Pd]>>C[Si](C)(CCCCOc1ccc(-c2ncc(O)cn2)cc1)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F",
        "output": "492"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Br.CC(=O)O.CCCCC(=O)Cc1ccc(OC)cc1>>CCCCC(=O)Cc1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.OCCCc1cccc(C(F)(F)F)c1>>CS(=O)(=O)OCCCc1cccc(C(F)(F)F)c1",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.COc1ccc(N)cc1.CS(=O)(=O)c1ccccc1Nc1nc(Cl)ncc1C(=O)Nc1c(F)cccc1Cl.Cl>>COc1ccc(Nc2ncc(C(=O)Nc3c(F)cccc3Cl)c(Nc3ccccc3S(C)(=O)=O)n2)cc1",
        "output": "907"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(OCc2nc(-c3ccc(N)c(F)c3)no2)CC1.CCC(=O)Cl.CCN(CC)CC.CCOC(C)=O>>CCC(=O)Nc1ccc(-c2noc(COC3CCN(C(=O)OC(C)(C)C)CC3)n2)cc1F",
        "output": "9"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCCCC1C(=O)N1CCC(C(=O)NC(CCCc2ccccc2)CCCc2ccccc2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(NC(CCCc1ccccc1)CCCc1ccccc1)C1CCN(C(=O)C2CCCCN2)CC1",
        "output": "634"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCO.CSc1nc(Cl)c2c(n1)CCN(c1ncccc1C(F)(F)F)CC2.Nc1ccc(C(F)(F)F)cc1>>CSc1nc2c(c(Nc3ccc(C(F)(F)F)cc3)n1)CCN(c1ncccc1C(F)(F)F)CC2",
        "output": "161"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCNCC1.O=[N+]([O-])c1ccc(C(F)(F)C(F)(F)F)c(CBr)c1>>CN1CCN(Cc2cc([N+](=O)[O-])ccc2C(F)(F)C(F)(F)F)CC1",
        "output": "248"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCCC1.CN1CCN(CCCN)CC1.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[K+].[K+]>>CN1CCN(CCCNc2ccc([N+](=O)[O-])cc2)CC1",
        "output": "572"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC1(C)CC(N)CC(C)(C)N1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCOC(C)=O.Cc1nn(-c2ccc(C#N)c(Br)c2)c2cccc(-c3cnc4ccccc4c3)c12.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2]>>Cc1nn(-c2ccc(C#N)c(NC3CC(C)(C)NC(C)(C)C3)c2)c2cccc(-c3cnc4ccccc4c3)c12",
        "output": "519"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N[C@H](c1ccccc1)[C@@H](O)CO.CC(C)(C)[Si](C)(C)Cl.CCOC(C)=O.ClCCl.O.c1c[nH]cn1>>CC(C)(C)OC(=O)N[C@H](c1ccccc1)[C@@H](O)CO[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1cccc(C(F)(F)F)c1.O=C(O)c1ccnc(Br)c1>>O=C(Nc1cccc(C(F)(F)F)c1)c1ccnc(Br)c1",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCOCC(O)(c2ccc(Cl)c(Cl)c2)C1.CI.CN(C)C=O.[H-].[Na+]>>COC1(c2ccc(Cl)c(Cl)c2)COCCN(C(=O)OC(C)(C)C)C1",
        "output": "140"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCN(CC)CC.CS(=O)(=O)c1nc(Cl)cc(-c2cn(S(=O)(=O)c3ccccc3)c3ncccc23)n1.N[C@H]1CC[C@H](N)CC1>>N[C@@H]1CC[C@@H](Nc2nc(Cl)cc(-c3cn(S(=O)(=O)c4ccccc4)c4ncccc34)n2)CC1",
        "output": "629"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCCCCN(OCc1ccccc1)C(=O)CCC(=O)O.Cl.Cl.ClCCl.NCCCCCNOCc1ccccc1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)NCCCCCN(OCc1ccccc1)C(=O)CCC(=O)NCCCCCNOCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCCCCCCCCCCCCC(=O)Cl.C[C@H](N)C(=O)N[C@H](CCC(=O)O)C(=O)OCc1ccccc1.C[Si](C)(C)C(C(N)=O)[Si](C)(C)C.ClCCl.O>>CCCCCCCCCCCCCCCCCC(=O)N[C@@H](C)C(=O)N[C@H](CCC(=O)O)C(=O)OCc1ccccc1",
        "output": "159"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCN1C(=O)C2(COc3cc4c(cc32)OCO4)c2c(Br)cccc21.CN(C)c1ccc(B(O)O)cn1.COc1ccc(B(O)O)cn1.O=C1N(Cc2ccc(C(F)(F)F)o2)c2cccc(Br)c2C12COc1cc3c(cc12)OCO3>>COc1ccc(-c2cccc3c2C2(COc4cc5c(cc42)OCO5)C(=O)N3Cc2ccc(C(F)(F)F)o2)cn1",
        "output": "899"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1ccc(C=CC=O)cc1.[Na+].[OH-]>>O=CC=Cc1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCl.N#CBr.O.O=C([O-])O.[Na+].c1ccc(Oc2ccc(Oc3ncnc4ccn(C5CNC5)c34)cc2)cc1>>N#CN1CC(n2ccc3ncnc(Oc4ccc(Oc5ccccc5)cc4)c32)C1",
        "output": "532"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCn1ncc2cc(-c3nc4ccc(C(=O)OC)cc4nc3N(C)C(C)C)ccc21.O.[Na+].[OH-]>>CCn1ncc2cc(-c3nc4ccc(C(=O)O)cc4nc3N(C)C(C)C)ccc21",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(CCl)cc1.Cc1c(C)c2c(c(C)c1O)C(c1ccc(N3CCN(C)CC3)cc1)C(C)(C)O2>>COc1ccc(COc2c(C)c(C)c3c(c2C)C(c2ccc(N4CCN(C)CC4)cc2)C(C)(C)O3)cc1",
        "output": "49"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)NCCCCN.COc1ccc2nc3cc(Cl)ccc3c(Cl)c2c1>>COc1ccc2nc3cc(Cl)ccc3c(NCCCCNC(C)(C)C)c2c1",
        "output": "78"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Brc1ccc2[nH]c3ccc(Br)cc3c2c1.Brc1ccc2c(c1)c1cc(Br)ccc1n2CC1CO1.CN(C)C=O.[H-].[Na+]>>OC(Cn1c2ccc(Br)cc2c2cc(Br)ccc21)Cn1c2ccc(Br)cc2c2cc(Br)ccc21",
        "output": "749"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1cc(CCCc2ccc3c(c2)OC(F)(F)O3)on1.O.[K+].[OH-]>>O=C(O)c1cc(CCCc2ccc3c(c2)OC(F)(F)O3)on1",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCON=C(c1ccc(Br)cc1)C1CCN(C2(C)CCNCC2)CC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cccc2c(O)cc(C(=O)O)nc12.F[P-](F)(F)(F)(F)F>>CCON=C(c1ccc(Br)cc1)C1CCN(C2(C)CCN(C(=O)c3cc(O)c4cccc(C)c4n3)CC2)CC1",
        "output": "605"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cc(Cc2ccccc2)nc(Cl)n1.Cc1cn(-c2ccc(N)cc2F)cn1.ClCCl>>Cc1cn(-c2ccc(Nc3nc(C)cc(Cc4ccccc4)n3)cc2F)cn1",
        "output": "808"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)C(=Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)cc1)c1ccccc1.[Cl-].[Li+].[NH4+].[OH-]>>Cc1oc(-c2ccccc2)nc1CCOc1ccc(C=C(C(=O)O)c2ccccc2)cc1",
        "output": "58"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N1CCC(N(C(=O)Nc2ncc(SCC(=O)N3CCCCC3)s2)[C@@H]2CC[C@@H](C)CC2)CC1.CC(=O)N1CCC(N(C(=O)Nc2ncc(SCC(=O)O)s2)[C@H]2CC[C@H](C)CC2)CC1.CN1CCNCC1>>CC(=O)N1CCC(N(C(=O)Nc2ncc(SCC(=O)N3CCN(C)CC3)s2)[C@@H]2CC[C@@H](C)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.Clc1nccnc1Cl.N[C@H]1C[C@H](Nc2nc3ccccc3s2)C1>>Clc1nccnc1N[C@@H]1C[C@@H](Nc2nc3ccccc3s2)C1",
        "output": "148"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1=COCCC1.C1CCOC1.Cc1ccc(S(=O)(=O)O)cc1.Cc1n[nH]c2cc(Br)cc(F)c12>>Cc1nn(C2CCCCO2)c2cc(Br)cc(F)c12",
        "output": "878"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1=C(C(=O)O)C(c2ccccc2C(F)(F)F)c2c(ccnc2OC(C)C)N1.CCOC(C)=O.CN(C)C=O.CN(CCO)Cc1ccccc1.ClCCl.O.O=C(Cl)C(=O)Cl.O=C(O)/C=C/C(=O)O.[Na+].[OH-].c1ccncc1>>CC1=C(C(=O)OCCN(C)Cc2ccccc2)C(c2ccccc2C(F)(F)F)c2c(ccnc2OC(C)C)N1",
        "output": "174"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(Cc1cn2c(N3CCN(C(=O)OC(C)(C)C)CC3)cccc2n1)C1CCCc2cccnc21.ClCCl.O=C(O)C(F)(F)F>>CN(Cc1cn2c(N3CCNCC3)cccc2n1)C1CCCc2cccnc21",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.Nc1ccccc1Oc1ccc(-c2nnnn2Cc2ccccc2)c(-c2nnnn2Cc2ccccc2)c1.O=C(Cl)c1cccc([N+](=O)[O-])c1>>O=C(Nc1ccccc1Oc1ccc(-c2nnnn2Cc2ccccc2)c(-c2nnnn2Cc2ccccc2)c1)c1cccc([N+](=O)[O-])c1",
        "output": "11"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.COc1cc(CC(=O)O)ccc1O.CS(C)=O.Cl.O.O=C([O-])[O-].O=[N+]([O-])c1c(Cl)ccc2ncccc12.[Cs+].[Cs+]>>COc1cc(CC(=O)O)ccc1Oc1ccc2ncccc2c1[N+](=O)[O-]",
        "output": "299"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CN[C@@H]1CCCC[C@H]1NC.N#Cc1cn[nH]c1.O=P([O-])([O-])[O-].Oc1cc(-c2c(I)ccc(Cl)c2F)ncn1.[Cu]I.[K+].[K+].[K+]>>N#Cc1cnn(-c2ccc(Cl)c(F)c2-c2cc(O)ncn2)c1",
        "output": "901"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCn1nnn(-c2cc(OCC(=O)OC)c(Cl)cc2Cl)c1=O.CO.Cl.O.[Na+].[OH-]>>CCCn1nnn(-c2cc(OCC(=O)O)c(Cl)cc2Cl)c1=O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.CCOCC.Fc1ccc(C2OCCO2)cc1Cc1ccccc1.O.O=S(=O)(O)O>>O=Cc1ccc(F)c(Cc2ccccc2)c1",
        "output": "655"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(C(N)c2cccc(C(F)(F)F)c2)cc1.O=C(O)CNC(=O)c1ccc(F)cc1>>Cc1ccc(C(NC(=O)CNC(=O)c2ccc(F)cc2)c2cccc(C(F)(F)F)c2)cc1",
        "output": "769"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc(Br)nc1.CN1CCCC1=O.O.O=C1CCCN1CCO.[H-].[Na+].[Na+].[OH-]>>O=C1CCCN1CCOc1ccc(Br)cn1",
        "output": "551"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)Nc1cc(N2CCC2)c(C(F)(F)F)cc1N.Cc1cc(-c2cccc(C(=O)CC(=O)OC(C)(C)C)c2)on1>>Cc1cc(-c2cccc(C(=O)CC(=O)Nc3cc(C(F)(F)F)c(N4CCC4)cc3NC(=O)OC(C)(C)C)c2)on1",
        "output": "929"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.C[Si](C)(C)C=[N+]=[N-].ClCCl.O=C(O)c1ccc2[nH]ccc2c1>>COC(=O)c1ccc2[nH]ccc2c1",
        "output": "195"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O.Oc1ccc2c(c1)[C@@]13CCCC[C@H]1[C@@H](C2)NCC3.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc13",
        "output": "694"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)OCC#N.Cc1ccc(C(N)CCC(C)C)c(C)c1.Cc1noc(C)c1C(O)c1cc2cc(CC(=O)O)ccc2o1>>Cc1ccc(C(CCC(C)C)NC(=O)Cc2ccc3oc(C(O)c4c(C)noc4C)cc3c2)c(C)c1",
        "output": "599"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.Brc1ccc2nc(OC3CCNCC3)sc2c1.C1CCOC1.CCN(CC)CC>>Brc1ccc2nc(OC3CCN(Cc4ccccc4)CC3)sc2c1",
        "output": "248"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)CCNc1ccnc2cc3c(cc12)OCO3.ClCCl.O=C(Cl)c1cc([N+](=O)[O-])ccc1Br>>CN(C)CCN(C(=O)c1cc([N+](=O)[O-])ccc1Br)c1ccnc2cc3c(cc12)OCO3",
        "output": "614"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1cccc(N2CC(O)C2)c1.[Pd]>>Nc1cccc(N2CC(O)C2)c1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CC(=O)c1cc(Cl)ccc1NS(=O)(=O)C(F)(F)F.CCO.Cl.NOc1ccc(F)cc1.[Na+]>>CC(=NOc1ccc(F)cc1)c1cc(Cl)ccc1NS(=O)(=O)C(F)(F)F",
        "output": "212"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Nc1ccc(CC[C@@]2(C(C)C)CC(O)=C(Sc3cc(C)c(CO)cc3C(C)(C)C)C(=O)O2)cc1.CC(=O)O.CCO.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O.O.[C].[Na+].[OH-]>>Cc1cc(SC2=C(O)C[C@@](CCc3ccc(N)cc3)(C(C)C)OC2=O)c(C(C)(C)C)cc1CO",
        "output": "66"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C(O)c1ccc(OCc2ccccc2)cc1F.O=S(Cl)Cl>>O=C(Cl)c1ccc(OCc2ccccc2)cc1F",
        "output": "3"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cc1ccnc([N+](=O)[O-])c1N.[Ni]>>Cc1ccnc(N)c1N",
        "output": "457"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOc1c(CN2CCC(n3ccc(C(=O)OC)c(C)c3=O)CC2)cc(C2CC2)c(-c2ccc(F)cc2)c1F.[Na+].[OH-]>>CCOc1c(CN2CCC(n3ccc(C(=O)O)c(C)c3=O)CC2)cc(C2CC2)c(-c2ccc(F)cc2)c1F",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)C(=O)Cl.CCN(CC)CC.CCNc1ccc(F)cc1F.Cc1ccccc1>>CCN(C(=O)C(C)(C)C)c1ccc(F)cc1F",
        "output": "160"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CCCCCC(O)c1ccc(O)cc1.ClCc1ccc[nH]1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CCCCCC(O)c1ccc(OCc2ccc[nH]2)cc1",
        "output": "616"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.Cc1ccc(C(=O)Cl)cc1NC(=O)C=Cc1cccnc1.ClCCl.Nc1ccc(F)cc1.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(C(=O)Nc2ccc(F)cc2)cc1NC(=O)C=Cc1cccnc1",
        "output": "11"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cc1nc(C(F)(F)F)ccc1C(=O)Nc1ccc(Cl)c(-c2nc3cc([N+](=O)[O-])ccc3[nH]2)c1.Cl.[Pd]>>Cc1nc(C(F)(F)F)ccc1C(=O)Nc1ccc(Cl)c(-c2nc3cc(N)ccc3[nH]2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccccc3C(=O)NC)n2)c(OC)c1)OCC.Cl>>CCOP(=O)(O)Cc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccccc3C(=O)NC)n2)c(OC)c1",
        "output": "618"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CCc1cccc(N2CCN(C(=O)OC(C)(C)C)CC2)c1>>CCc1cccc(N2CCNCC2)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.COc1cccc(S(=O)(=O)Cl)c1.Nc1ccc(Cl)cc1Cc1ccccc1Cl.c1ccncc1>>COc1cccc(S(=O)(=O)Nc2ccc(Cl)cc2Cc2ccccc2Cl)c1",
        "output": "68"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "NC1CC1.O=C(O)COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1>>O=C(COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)NC1CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C=O.COC(C)(C)C.Cc1ccccc1.Cl.Nc1ccc(SC(F)(F)F)cc1.O=C(O)c1cnc(Cl)c(Br)c1.O=S(Cl)Cl>>O=C(Nc1ccc(SC(F)(F)F)cc1)c1cnc(Cl)c(Br)c1",
        "output": "739"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCCCCN.CO.O=C1CCN(S(=O)(=O)c2ccc(CNC(=O)c3ccc(Cl)cc3)cc2)CC1>>CCCCCCNC1CCN(S(=O)(=O)c2ccc(CNC(=O)c3ccc(Cl)cc3)cc2)CC1",
        "output": "236"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.NCCC1CCc2ccc3c(c21)NC(=O)CO3.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>NCCC1CCc2ccc3c(c21)NCCO3",
        "output": "363"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#Cc1cccc(N)c1.C1CCOC1.CC(C)(C)OC(=O)Nc1cncc(Br)c1.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>CC(C)(C)OC(=O)Nc1cncc(C#Cc2cccc(N)c2)c1",
        "output": "719"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COc1ccc(-c2cc(F)c3cc(O)ccc3c2)cc1.O=C1CCC(=O)N1Cl>>COc1ccc(-c2cc(F)c3c(Cl)c(O)ccc3c2)cc1",
        "output": "121"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cc(CO)ccc1Cl.ClCCl.O=S(Cl)Cl>>COc1cc(CCl)ccc1Cl",
        "output": "81"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)CSc1ccc(S(C)(=O)=O)cc1C(=O)O.CS(=O)(=O)c1ccc(N2CCNCC2)c(F)c1>>CC(C)CSc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(S(C)(=O)=O)cc2F)CC1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COC(=O)CCCCCBr.Cc1c(-c2cccnc2)[nH]c2ccc(Cl)cc12.[H-].[Na+]>>COC(=O)CCCCCn1c(-c2cccnc2)c(C)c2cc(Cl)ccc21",
        "output": "470"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.O=C1CCc2ccccc2N1C1CCNCC1.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)N1CCC(N2C(=O)CCc3ccccc32)CC1",
        "output": "323"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCNC(=O)c1ccc(Nc2ncc(F)c(N3CC4CC(C3)N4C(=O)C(F)(F)F)n2)cc1C.CO.[Na+].[OH-]>>CCNC(=O)c1ccc(Nc2ncc(F)c(N3CC4CC(C3)N4)n2)cc1C",
        "output": "703"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCc2ccc([N+](=O)[O-])cc2C1.CO.[OH-].[OH-].[Pd+2]>>CC(C)(C)OC(=O)N1CCc2ccc(N)cc2C1",
        "output": "71"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccccc1.NC1c2cc([N+](=O)[O-])ccc2CCC1O.O.O=C(Cl)c1ccc(-c2ccccc2)cc1.[Na+].[OH-]>>O=C(NC1c2cc([N+](=O)[O-])ccc2CCC1O)c1ccc(-c2ccccc2)cc1",
        "output": "411"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC[C@@H]1CC[C@@H](COC)N1.N#Cc1c(Cl)[nH]c2cccnc12>>COC[C@@H]1CC[C@@H](COC)N1c1[nH]c2cccnc2c1C#N",
        "output": "296"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CN(Cc1cc(-c2ccccc2C=O)n(S(=O)(=O)c2cccnc2)c1)C(=O)OC(C)(C)C.CO.O.[BH4-].[Na+]>>CN(Cc1cc(-c2ccccc2CO)n(S(=O)(=O)c2cccnc2)c1)C(=O)OC(C)(C)C",
        "output": "356"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COC(=O)C1CC(c2ccc(OC(F)(F)F)c(C)c2)CN(C(=O)Oc2ccc([N+](=O)[O-])cc2)C1.O=C([O-])[O-].OC1CCNCC1.[K+].[K+]>>COC(=O)C1CC(c2ccc(OC(F)(F)F)c(C)c2)CN(C(=O)N2CCC(O)CC2)C1",
        "output": "770"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccccc1CNC(=O)C1(CCCCBr)c2ccccc2-c2ccccc21.c1ccc2nc(N3CCNCC3)ccc2c1>>COc1ccccc1CNC(=O)C1(CCCCN2CCN(c3ccc4ccccc4n3)CC2)c2ccccc2-c2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)c1ccc2c(c1)OC1(O)c3cccc([N+](=O)[O-])c3C(=O)C21NC(=O)c1cc2ccccc2o1.CCO.Cl.O.[Fe]>>CC(C)c1ccc2c(c1)OC1(O)c3cccc(N)c3C(=O)C21NC(=O)c1cc2ccccc2o1",
        "output": "706"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCC.CCOC(C)=O.CN(C)C=O.CO.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ncc(Br)s1.O=C([O-])O.[Na+]>>COC(=O)c1ncc(Br)s1",
        "output": "195"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCCCOC(c1ccccc1)(c1ccccc1)c1ccccc1.CN(C)C=O.OCCO.[H-].[Na+]>>OCCOCCCOC(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "95"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.CC(C)(CO)c1ccc(C(=O)O)cc1.CI.O=C([O-])O.O=S(=O)([O-])[O-].[Ca+2].[Na+]>>COC(=O)c1ccc(C(C)(C)CO)cc1",
        "output": "415"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)C(=O)Cl.CC(C)(C)OC(=O)NCC(=O)O.CC(N)(Cc1ccccc1)c1ccccc1.CCN(CC)CC.Cl.ClCCl>>CC(C)(C)OC(=O)NCC(=O)NC(C)(Cc1ccccc1)c1ccccc1",
        "output": "599"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(C)=O.CCOC(=O)CCCCCCCBr.O=C([O-])[O-].[K+].[K+].c1ccc(-c2c[nH]cn2)cc1>>CCOC(=O)CCCCCCCn1cnc(-c2ccccc2)c1",
        "output": "276"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOc1cc2ncnc(Nc3ccc4c(cnn4Cc4cccc(F)c4)c3)c2cc1[N+](=O)[O-].Cl.[Fe].[Na+].[OH-]>>CCOc1cc2ncnc(Nc3ccc4c(cnn4Cc4cccc(F)c4)c3)c2cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C(=O)O)c1ccc(-c2cncnc2)cc1.CCC(C)CN>>CCC(C)CNC(=O)C(C)(C)c1ccc(-c2cncnc2)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1noc(C)c1CC(=O)O.Cl.N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1>>Cc1noc(C)c1CC(=O)N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1",
        "output": "133"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)C(C)(C)N1CCC(Cc2nc3c(N4CCOCC4)nc(-n4c(C)nc5ccccc54)nc3n2C)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CCN(C(C)(C)CO)CC3)n(C)c2n1",
        "output": "343"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)c1ccn(C(C)C)c(=O)c1.O.[Li+].[OH-]>>CC(C)n1ccc(C(=O)O)cc1=O",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCOC(C)=O.FC(F)(F)c1ccnc(Cl)n1.Nc1cc(-c2cnc(C3(O)CCC3)s2)cc([N+](=O)[O-])c1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2]>>O=[N+]([O-])c1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C3(O)CCC3)s2)c1",
        "output": "808"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.O=C(O)CSc1ccc2c(c1)C(=O)c1sccc1CO2.O=C([O-])O.[K+]>>COC(=O)CSc1ccc2c(c1)C(=O)c1sccc1CO2",
        "output": "415"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.C[Si](C)(C)C#Cc1ccc2nc(OC3COC3)n(-c3ccnc(N)n3)c2c1.[F-]>>C#Cc1ccc2nc(OC3COC3)n(-c3ccnc(N)n3)c2c1",
        "output": "337"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#Cc1cc(Cl)ccc1OCC(=O)OC(C)(C)C.CCCS(=O)(=O)c1ccc(F)c(C#C[Si](C)(C)C)c1.CS(=O)(=O)c1cc(Br)ccc1-c1ccccc1>>CC(C)(C)OC(=O)COc1ccc(Cl)cc1C#Cc1ccc(-c2ccccc2)c(S(C)(=O)=O)c1",
        "output": "659"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.COc1ccc(OC)c(C)c1.O=[N+]([O-])O>>COc1cc([N+](=O)[O-])c(OC)cc1C",
        "output": "21"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCOCCOCCOCCOCCO1.CO.C[O-].Cn1c(=O)c2cncc(F)c2c2ccc(Cl)cc21.O.[Na+]>>COc1cncc2c(=O)n(C)c3cc(Cl)ccc3c12",
        "output": "823"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "FC(F)(F)c1nnc2ccc(N3CCNCC3)nn12.O=Cc1ccc([N+](=O)[O-])cc1>>O=[N+]([O-])c1ccc(CN2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1",
        "output": "567"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)NCCC1CCc2ccc(N)c(O)c21.Cl.O.O=C(Cl)CCCc1ccccc1.c1ccncc1>>CC(=O)NCCC1CCc2ccc(NC(=O)CCCc3ccccc3)c(O)c21",
        "output": "9"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COc1cc(Nc2ccnc3ccc(SC4CCOCC4)cc23)ccc1Cl.O.O=S([O-])OO.[K+]>>COc1cc(Nc2ccnc3ccc(S(=O)(=O)C4CCOCC4)cc23)ccc1Cl",
        "output": "730"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(O)cc1C.ClCC1CO1>>Cc1ccc(OCC2CO2)cc1C",
        "output": "15"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccccc1.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>Cc1ccccc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.CNOC.CSc1cccc(C(=O)O)c1.O=C(n1ccnc1)n1ccnc1>>CON(C)C(=O)c1cccc(SC)c1",
        "output": "828"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COc1cc(C#N)ccc1N1CCOc2cc(S(=O)(=O)Cl)ccc21.ClCCl.Oc1c(F)c(F)c(F)c(F)c1F>>COc1cc(C#N)ccc1N1CCOc2cc(S(=O)(=O)Oc3c(F)c(F)c(F)c(F)c3F)ccc21",
        "output": "380"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)[O-].Fc1cc(Br)ccn1.OCCCF.[K+]>>FCCCOc1cc(Br)ccn1",
        "output": "541"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)C(C)C(c1ccccc1)c1ccc2[nH]ncc2c1.CS(C)=O.Cl.[Na+].[OH-]>>CC(C(=O)O)C(c1ccccc1)c1ccc2[nH]ncc2c1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)[C@H](CN)NS(=O)(=O)c1ccccc1.CCOC(C)=O.CN(C)C=O.CN1CCOCC1.Cl.Cl.ClCCCl.O=C(O)c1ccc(OCCNc2nccs2)cc1.On1nnc2ccccc21>>CC(C)(C)OC(=O)[C@H](CNC(=O)c1ccc(OCCNc2nccs2)cc1)NS(=O)(=O)c1ccccc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)[C@H](CNC(=O)c1ccc(CCC(=O)NC2=NCCCN2)cc1)NC(=O)OCc1ccccc1.O=C(O)C(F)(F)F>>O=C(CCc1ccc(C(=O)NC[C@H](NC(=O)OCc2ccccc2)C(=O)O)cc1)NC1=NCCCN1",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C#N)cc1B(O)O.COc1ccccc1B(O)O.Cc1cc(Cl)ccc1C1c2c(cc(Br)n2C(C)C)C(=O)N1[C@@H]1CC[C@@H](O)CC1.Cc1ccc(Cl)cc1N1C(=O)c2cc(Br)n(C(C)C)c2C1c1ccc(Cl)cc1>>COc1ccccc1-c1cc2c(n1C(C)C)C(c1ccc(Cl)cc1C)N([C@@H]1CC[C@@H](O)CC1)C2=O",
        "output": "869"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCC#Cc1c(C(C)N=[N+]=[N-])cc2ccccn12.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCC#Cc1c(C(C)N)cc2ccccn12",
        "output": "89"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1ccccc1.CCCCN.CCOCC.Cc1cc(I)ccc1N.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Cc1cc(C#Cc2ccccc2)ccc1N",
        "output": "664"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CO.COC(=O)c1ccccc1-c1ccc2[nH]c(COc3ccc(C(F)(F)F)cc3)nc2c1.Cl.O.[Li+].[OH-]>>O=C(O)c1ccccc1-c1ccc2[nH]c(COc3ccc(C(F)(F)F)cc3)nc2c1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)CC(C)(C)C[C@H](CC(=O)N1CCOCC1)C(=O)O.CC[C@H](N)C(=O)c1ncco1.Cl>>CC[C@H](NC(=O)[C@@H](CC(=O)N1CCOCC1)CC(C)(C)CC(C)C)C(=O)c1ncco1",
        "output": "645"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)C(C)(C)N1COCN(c2ccccc2)C1=O.Cl.[Na+].[OH-]>>CC(C)(C(=O)O)N1COCN(c2ccccc2)C1=O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)n1ncc2cc(C=O)c(F)cc21.CCOC(C)=O.CO.O.[BH4-].[Na+]>>CC(C)(C)OC(=O)n1ncc2cc(CO)c(F)cc21",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cc(Cl)ccc1C(=O)O.COc1cc(F)ccc1C(=O)O.NC1COCCn2c1nc(-c1ccncc1)cc2=O>>COc1cc(F)ccc1C(=O)NC1COCCn2c1nc(-c1ccncc1)cc2=O",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)CC(=O)Nc2ccccc21.CCOCC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC1(C)CCNc2ccccc21",
        "output": "112"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)CNC(=O)c1ccc(S(=O)(=O)F)cc1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)CNC(=O)c1ccc(S(=O)(=O)F)cc1",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)c2ncn([C@H]3CCNC3)c2-c2ccccc2)[C@H](Cc2ccccc2)C1.CC(C)(O)C(=O)O.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ncn([C@H]3CCN(C(=O)C(C)(C)O)C3)c2-c2ccccc2)[C@H](Cc2ccccc2)C1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COc1cc(OCCN(C)C)c2[nH]c(C(=O)N3CC(CCl)c4c3cc([N+](=O)[O-])c3ccccc43)cc2c1.O=[Pt]=O>>COc1cc(OCCN(C)C)c2[nH]c(C(=O)N3CC(CCl)c4c3cc(N)c3ccccc43)cc2c1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNCCc1ccccc1.NCCc1ccccc1.O=C(c1ccccc1C(F)(F)F)N1CCN(c2ccc(Cl)nn2)CC1>>O=C(c1ccccc1C(F)(F)F)N1CCN(c2ccc(NCCc3ccccc3)nn2)CC1",
        "output": "241"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1=CC(C)(C)c2ccc(O)cc2O1.CN(C)C=O.Cc1ccccc1.O=[N+]([O-])c1ccc(Cl)cc1.[K+].[OH-]>>CC1=CC(C)(C)c2ccc(Oc3ccc([N+](=O)[O-])cc3)cc2O1",
        "output": "299"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CC#N.CON(C)C(=O)CCCCl.O=C([O-])[O-].[K+].[K+]>>CON(C)C(=O)CCCN1CCOCC1",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.CO.COc1cc2c(c(OC)c1/C=C/c1ccc(CO)cc1)C(C)(C)CCC2(C)C.O.[H-].[H][H].[Na+]>>COCc1ccc(/C=C/c2c(OC)cc3c(c2OC)C(C)(C)CCC3(C)C)cc1",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(-c2ncccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CN)n1.FC(F)(F)c1cnc(Cl)nc1>>Cc1ccc(-c2ncccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ncc(C(F)(F)F)cn2)n1",
        "output": "544"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1c(C)c(-c2ccc(OCc3ccccc3-n3nnn(C)c3=O)c(C)c2)nn1C.CCOC(=O)c1c(C)c(-c2ccc(OCc3ccccc3-n3nnn(C)c3=O)c(C)c2)nn1CC>>CCn1nc(-c2ccc(OCc3ccccc3-n3nnn(C)c3=O)c(C)c2)c(C)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1ccc(F)cc1C.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)c1ccc(F)cc1CBr",
        "output": "545"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NC(CCC(=O)O)C(=O)OC(C)(C)C.CCOCC.CN1CCOCC1.CO.Cl.[BH4-].[Na+]>>CC(C)(C)OC(=O)NC(CCCO)C(=O)OC(C)(C)C",
        "output": "231"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(N(C(=O)c2c3ccccc3nc3sccc23)S(=O)(=O)CCCC(=O)O)cc1.O=C1CCC(=O)N1O.[C-]#[N+]CCN1CCOCC1>>COc1ccc(N(C(=O)c2c3ccccc3nc3sccc23)S(=O)(=O)CCCC(=O)ON2C(=O)CCC2=O)cc1",
        "output": "303"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Cc1ccc(C(=O)Nc2ccc3c(c2)CCN3)c(N2CCC(C)CC2)n1.F[P-](F)(F)(F)(F)F.O.O=C(O)Cn1cnnn1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>Cc1ccc(C(=O)Nc2ccc3c(c2)CCN3C(=O)Cn2cnnn2)c(N2CCC(C)CC2)n1",
        "output": "315"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(C)=O.CCCCC[C@H]1CC[C@H](CCCCc2ccc(O)cc2)CC1.CI.O.O=C([O-])[O-].[K+].[K+]>>CCCCC[C@H]1CC[C@H](CCCCc2ccc(OC)cc2)CC1",
        "output": "62"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CN.Fc1cccc(COc2ccc(Nc3ncnc4[nH]nc(OCCCl)c34)cc2Cl)c1.O>>CNCCOc1n[nH]c2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c12",
        "output": "279"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1ccc(Cl)nc1.[NH4+]>>CC(=O)c1ccc(N)nc1",
        "output": "388"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CS(=O)(=O)c1cc(F)c(CN2CCN(C3CCNCC3)C2=O)cc1F.Fc1cc(C(F)(F)F)cnc1F.O=C(O)C(F)(F)F>>CS(=O)(=O)c1cc(F)c(CN2CCN(C3CCN(c4ncc(C(F)(F)F)cc4F)CC3)C2=O)cc1F",
        "output": "756"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.O=S(Cl)Cl.OCCCCCCCCCCOCc1ccccc1>>ClCCCCCCCCCCOCc1ccccc1",
        "output": "96"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COCC1CCC(c2ccccc2OC)N1CCN1C(=O)c2ccccc2C1=O.NN>>COCC1CCC(c2ccccc2OC)N1CCN",
        "output": "242"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1ccccc1.CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1cc(Oc2ccccc2)ccc1O.[K+].[K+]>>O=[N+]([O-])c1cc(Oc2ccccc2)ccc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1ccc(C2COCCO2)c2sc(N)nc12.ClC(Cl)Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccccc1F>>COc1ccc(C2COCCO2)c2sc(NC(=O)c3ccccc3F)nc12",
        "output": "918"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCC(NC(=O)Cc1cncn1Cc1ccc2ccccc2c1)C(=O)O.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.ClCCCl.NCc1cccc2ccccc12.On1nnc2ccccc21>>CC(C)(C)OC(=O)NCC(NC(=O)Cc1cncn1Cc1ccc2ccccc2c1)C(=O)NCc1cccc2ccccc12",
        "output": "599"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrBr.CC(=O)O.CC(O)CNc1ccnc2cc(Cl)ccc12.O.[Na+].[OH-]>>CC(O)CNc1c(Br)cnc2cc(Cl)ccc12",
        "output": "292"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCBr.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.O.O=C(O)Cc1nc(-c2ccc(Cl)cc2)oc1Oc1ccc(Cl)cc1>>CCOC(=O)Cc1nc(-c2ccc(Cl)cc2)oc1Oc1ccc(Cl)cc1",
        "output": "416"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1ccc2[nH]c3c(c2c1)C(C)CNC3=O.CO.Cl.O.[Li+].[OH-]>>CC1CNC(=O)c2[nH]c3ccc(C(=O)O)cc3c21",
        "output": "5"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=O.CC#N.CC(=O)O.O=S(=O)(c1ccccc1)N1CC2COCC(C1)N2.[BH3-]C#N.[Na+]>>CN1C2COCC1CN(S(=O)(=O)c1ccccc1)C2",
        "output": "217"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)CNCCN1.COc1cc(CCc2cc(NC(=O)c3cnc(Cl)cn3)[nH]n2)cc(OC)c1.CS(C)=O>>COc1cc(CCc2cc(NC(=O)c3cnc(N4CCNC(C)(C)C4)cn3)[nH]n2)cc(OC)c1",
        "output": "505"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1cc([N+](=O)[O-])ccc1O.CCCCCC.CCOC(=O)N=NC(=O)OCC.CCOC(C)=O.ClCCl.N#N.O.OCc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)Nc1cc([N+](=O)[O-])ccc1OCc1ccccc1",
        "output": "347"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CN)C(=O)O.CCN(C(C)C)C(C)C.CCOC(=O)OC(=O)OCC.CCOC(C)=O.COC(=O)[C@@H](N)Cc1ccccc1.Cl.ClCCl>>COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CN)NC(=O)OC(C)(C)C",
        "output": "129"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)NCCO[C@@H](c1cc(F)cc(F)c1O)[C@@H]1CCCN(C(=O)N[C@@H](CC2CCCCC2)CN(C)C(=O)OC(C)(C)C)C1.[Pd]>>CNC[C@H](CC1CCCCC1)NC(=O)N1CCC[C@@H]([C@@H](OCCNC(=O)OC)c2cc(F)cc(F)c2O)C1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CN1CCC(Oc2ccc([N+](=O)[O-])cc2)C1.O=C(O)C(F)(F)F.[Pd]>>CN1CCC(Oc2ccc(N)cc2)C1",
        "output": "202"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCOC(C)=O.Fc1ccc([C@H]2C[C@@H]2CNc2ccnc(Cl)c2C(F)(F)F)cc1.NN.O>>NNc1nccc(NC[C@H]2C[C@@H]2c2ccc(F)cc2)c1C(F)(F)F",
        "output": "417"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)n1c(-c2cc([N+](=O)[O-])cn(COCC[Si](C)(C)C)c2=O)cc2ccccc21.O.[F-].[K+].[Pd+2]>>CC(C)(C)OC(=O)n1c(-c2cc(N)cn(COCC[Si](C)(C)C)c2=O)cc2ccccc21",
        "output": "269"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1ccc(C2=NN(C3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)C(=O)[C@H]3CCCC[C@@H]23)cc1OC.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1c[nH]c2c(-c3c(OCC4CC4)ccc4c3OCO4)ncnc12.O=C([O-])O.[Na+]>>COc1ccc(C2=NN(C3CCN(C(=O)[C@H](Cc4ccccc4)NC(=O)c4c[nH]c5c(-c6c(OCC7CC7)ccc7c6OCO7)ncnc45)CC3)C(=O)[C@H]3CCCC[C@@H]23)cc1OC",
        "output": "989"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CN1CCN(c2ccc([N+](=O)[O-])cc2)CC1.[H][H].[Pd]>>CN1CCN(c2ccc(N)cc2)CC1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(N(Cc1ccccc1)Cc1ccccc1)C(C)(C)O.CO.O.O=P([O-])(O)O.[K+].[Na+].[OH-]>>CC(C)(O)C(C(=O)O)N(Cc1ccccc1)Cc1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN.O=S1(=O)N(CCCCCCBr)c2ccccc2N1c1ccccc1F>>CNCCCCCCN1c2ccccc2N(c2ccccc2F)S1(=O)=O",
        "output": "147"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C(O)c1cc2occc2[nH]1.OCC1CCCCC1>>O=C(OCC1CCCCC1)c1cc2occc2[nH]1",
        "output": "331"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.NC(=O)c1cccc2c1CCCc1ccccc1-2.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCc1cccc2c1CCCc1ccccc1-2",
        "output": "215"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.COc1ccc(C2CCC(C)(C)CC2)cc1.ClCCl>>CC1(C)CCC(c2ccc(O)cc2)CC1",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCCN(CCCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)c1ccc(C=Cc2cccs2)c(OCc2ccccc2)c1.CCOCC.CN(C)C=O.II.[Li]CCCC>>CCCCN(CCCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)c1ccc(C=Cc2ccc(C=O)s2)c(OCc2ccccc2)c1",
        "output": "617"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1cc(C)nc(Cl)n1.[Na]>>COC(=O)c1cc(C)nc(OC)n1",
        "output": "37"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C(=O)O)n1ccc(-c2cc(Cl)ccc2C#N)cc1=O.CC(C)(C)OC(=O)n1[nH]c(=O)cc1-c1ccc(N)cc1>>CC(C(=O)Nc1ccc(-c2cc(=O)[nH]n2C(=O)OC(C)(C)C)cc1)n1ccc(-c2cc(Cl)ccc2C#N)cc1=O",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCCc1ccc(Cl)cc1Br.CCCCCC.CN(C)C=O.O.[Li]CCCC>>CC(C)(C)[Si](C)(C)OCCc1ccc(Cl)cc1C=O",
        "output": "638"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COc1nccc2oc(-c3cnc4ccc(Cl)nn34)cc12.OC[C@@H]1CCCCN1.[H-].[Na+]>>COc1nccc2oc(-c3cnc4ccc(OC[C@@H]5CCCCN5)nn34)cc12",
        "output": "407"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)CCN.NCC(O)C(=O)O.[Na+].[OH-]>>CC(C)(C)OC(=O)NCC(O)C(=O)O",
        "output": "631"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrBr.Cc1ccc(NC2CCCCC2)cc1.ClCCl.[K+].[OH-]>>Cc1ccc(NC2CCCCC2)c(Br)c1",
        "output": "98"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)C(C)(C)Cc1cc2nc(OCc3ccccn3)ccc2n1Cc1ccc(Cl)cc1.CCOC(C)=O.CO.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li+].[OH-]>>CC(C)(Cc1cc2nc(OCc3ccccn3)ccc2n1Cc1ccc(Cl)cc1)C(=O)O",
        "output": "281"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOc1cc2c(c3c1OC(C)(C)C3)C(c1ccc(/C=C/C(=O)OC)c(OC)c1)=NC(C)(C)C2.CO.[Na+].[OH-]>>CCOc1cc2c(c3c1OC(C)(C)C3)C(c1ccc(/C=C/C(=O)O)c(OC)c1)=NC(C)(C)C2",
        "output": "58"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C(=O)O)(c1ccccc1)c1ccccc1.CC(C)C(=O)Nc1cc(C2CCN(CCCN)CC2)ccc1F>>CC(C)C(=O)Nc1cc(C2CCN(CCCNC(=O)C(C)(c3ccccc3)c3ccccc3)CC2)ccc1F",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCN(CC[C@H](N)c3ccccc3)CC2)c1.O=S(=O)(Cl)c1cc(Cl)cc(Cl)c1O>>CC(C)C(=O)Nc1cccc(C2CCN(CC[C@H](NS(=O)(=O)c3cc(Cl)cc(Cl)c3O)c3ccccc3)CC2)c1",
        "output": "530"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC.CCOC(C)=O.CN(C)C=O.Fc1cc(Cl)cc(Br)c1.O=C([O-])[O-].[K+].[K+].c1ccc(-c2cn[nH]c2)nc1>>Clc1cc(Br)cc(-n2cc(-c3ccccn3)cn2)c1",
        "output": "751"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(CC(O)c2ccc(F)cc2)c2ncnn12.O=C([O-])O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(CC(=O)c2ccc(F)cc2)c2ncnn12",
        "output": "32"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1ccc(C)[nH]1.ClCCCl.O=C(Cl)Cc1ccc(C(F)(F)F)cc1>>CCOC(=O)c1cc(C(=O)Cc2ccc(C(F)(F)F)cc2)c(C)[nH]1",
        "output": "524"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)C(Cc1ccc(O)cc1)NC(=O)C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1.O.O.[Li+].[OH-]>>CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)NC(Cc1ccc(O)cc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COc1ccc(OCC2CO2)cc1OC.Cc1c(NCCN)n(C)c(=O)n(C)c1=O.ClCCl.O>>COc1ccc(OCC(O)CNCCNc2c(C)c(=O)n(C)c(=O)n2C)cc1OC",
        "output": "16"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.N#Cc1cc(F)ccc1[N+](=O)[O-].O.O=C([O-])[O-].OCc1ccccc1.[K+].[K+]>>N#Cc1cc(OCc2ccccc2)ccc1[N+](=O)[O-]",
        "output": "485"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CO.COC(=O)c1nn(C)cc1NC(=O)c1cccc(-c2cnn(CC#CCCCNC(=O)OC(C)(C)C)c2)n1.Cl.Cl>>COC(=O)c1nn(C)cc1NC(=O)c1cccc(-c2cnn(CC#CCCCN)c2)n1",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Br.CCCN1CCC=C(c2cccc(OC)c2)C1.O.[NH4+].[OH-].c1cc[nH+]cc1>>CCCN1CCC=C(c2cccc(O)c2)C1",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.C[C@@H]1CN(C(=O)Nc2ccc([N+](=O)[O-])cc2)[C@@H](C)CN1c1ccc(C#N)c(C(F)(F)F)c1.O.[Cl-].[Fe].[NH4+]>>C[C@@H]1CN(C(=O)Nc2ccc(N)cc2)[C@@H](C)CN1c1ccc(C#N)c(C(F)(F)F)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)c(Cc1ccc(NC(=O)c3ccccc3)cc1)cn2C.O.[Na+].[OH-]>>Cn1cc(Cc2ccc(NC(=O)c3ccccc3)cc2)c2cc(C(=O)O)ccc21",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(O)C(=O)O.CNCCOc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12>>CN(CCOc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)C(=O)C(C)(C)O",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc([N+](=O)[O-])cn2)c(F)c1.[Pd]>>COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(N)cn2)c(F)c1",
        "output": "269"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CCOCCBr.Cc1cc(Cl)ccc1C(CC(=O)c1ccc(=O)[nH]c1)c1ccc(S(C)(=O)=O)cc1.O=C([O-])[O-].[I-].[K+].[K+]>>CCOCCn1cc(C(=O)CC(c2ccc(S(C)(=O)=O)cc2)c2ccc(Cl)cc2C)ccc1=O",
        "output": "470"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)Cc1cc2ccc(Cl)cc2c(-c2ccc(S(=O)(=O)c3ccccc3OC(F)(F)F)cc2)c1C.O.O.[Li+].[OH-]>>Cc1c(CC(=O)O)cc2ccc(Cl)cc2c1-c1ccc(S(=O)(=O)c2ccccc2OC(F)(F)F)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CC2(CCN1)OCCO2.ClCCl.N#Cc1ccc(S(=O)(=O)Cl)cc1.O=C([O-])[O-].[Na+].[Na+]>>N#Cc1ccc(S(=O)(=O)N2CCC3(CC2)OCCO3)cc1",
        "output": "99"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cc1ccc(-c2cc(C(=O)O)cc([N+](=O)[O-])c2)cc1.O=S(Cl)Cl>>COC(=O)c1cc(-c2ccc(C)cc2)cc([N+](=O)[O-])c1",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=C1CCCC(C)(C)C1C(=O)O.CC(C)=O.CCBr.O=C([O-])[O-].[K+].[K+].[Na+].[OH-]>>C=C1CCCC(C)(C)C1C(=O)OCC",
        "output": "416"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Fc1cccc(F)c1.O=C(Cl)CCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(CCCl)c1ccc(F)cc1F",
        "output": "31"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC[SiH](CC)CC.ClCCl.O=C(O)C(F)(F)F.O=C1N(Cc2ccc(C(F)(F)F)o2)c2ccccc2C1(O)c1cc2c(cc1O)OC(F)(F)O2>>O=C1C(c2cc3c(cc2O)OC(F)(F)O3)c2ccccc2N1Cc1ccc(C(F)(F)F)o1",
        "output": "964"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(C(F)(F)F)cc2Cl)CC1.ClCCl.O=C(O)C(F)(F)F>>FC(F)(F)c1ccc(N2CCNCC2)c(Cl)c1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C(OC(C)(C)C)OC(C)(C)C.COC(=O)c1ccc(O)c(C(=O)O)c1.Cc1ccccc1>>COC(=O)c1ccc(O)c(C(=O)OC(C)(C)C)c1",
        "output": "768"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=S(=O)(c1ccc2ccccc2c1)C1CCNCC1.O=[N+]([O-])c1ccc(Cl)nc1>>O=[N+]([O-])c1ccc(N2CCC(S(=O)(=O)c3ccc4ccccc4c3)CC2)nc1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)C(C)(C)Oc1ccc(OCc2ccc(-c3ccc(C(F)(F)F)cc3)nn2)cc1C.[Na+].[OH-]>>Cc1cc(OCc2ccc(-c3ccc(C(F)(F)F)cc3)nn2)ccc1OC(C)(C)C(=O)O",
        "output": "192"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1cccc(Oc2cc(Nc3ccc4c(c3)CN(C(=O)OC(C)(C)C)CC4)c([N+](=O)[O-])cn2)c1.CO.[H][H].[Pd]>>CC(=O)Nc1cccc(Oc2cc(Nc3ccc4c(c3)CN(C(=O)OC(C)(C)C)CC4)c(N)cn2)c1",
        "output": "269"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1c(N)cc(C(C)(C)C)cc1NS(C)(=O)=O.Cc1ccc(-c2cn(-c3cc(C(=O)O)ccc3C)nn2)cn1>>COc1c(NC(=O)c2ccc(C)c(-n3cc(-c4ccc(C)nc4)nn3)c2)cc(C(C)(C)C)cc1NS(C)(=O)=O",
        "output": "50"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Clc1nc(-c2ccccc2)cc(N2CCOCC2)n1.Nc1ccc(OC(F)(F)F)cc1>>FC(F)(F)Oc1ccc(Nc2nc(-c3ccccc3)cc(N3CCOCC3)n2)cc1",
        "output": "907"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.COc1ccc(C(C)C(O)(c2ccc3c(c2)N(C)C(=O)CO3)C(F)(F)F)c(Cl)c1.ClCCl>>CC(c1ccc(O)cc1Cl)C(O)(c1ccc2c(c1)N(C)C(=O)CO2)C(F)(F)F",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)COc1ccc(C(CC)=C(c2ccc(O)cc2)c2ccc(O)cc2)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1ccc(OCCO)cc1",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC1c2cc(F)ccc2-c2ccccc2N1S(=O)(=O)c1ccc(OC)c(C)c1.CCCC[N+](CCCC)(CCCC)CCCC.ClB(Cl)Cl.ClCCl.[I-]>>CCC1c2cc(F)ccc2-c2ccccc2N1S(=O)(=O)c1ccc(O)c(C)c1",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(C)=O.[OH-].[OH-].[Pd+2].c1ccc(COc2ccc(-n3nccn3)cc2)cc1>>Oc1ccc(-n2nccn2)cc1",
        "output": "698"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1ccccc1.CCOC(=O)C(=O)OCC.CCOC(C)=O.CN(C)C=O.Cl.O.[H-].[Na+]>>CCOC(=O)C(=O)CC(=O)c1ccccc1",
        "output": "526"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)O.CC(C)(C)OC(=O)N1CCN(c2ccc(C#N)cc2F)CC1.[K+].[OH-]>>CC(C)(C)OC(=O)N1CCN(c2ccc(C(N)=O)cc2F)CC1",
        "output": "419"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.II.O=S([O-])O.[K+].[Na+].[OH-].c1cc2[nH]ncc2cc1-c1cncc(C2CC2)n1>>Ic1n[nH]c2ccc(-c3cncc(C4CC4)n3)cc12",
        "output": "923"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)CCCC(C)CCBr.CCO.O.Oc1cccc(Br)c1.[K+].[OH-]>>CC(C)CCCC(C)CCOc1cccc(Br)c1",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.CO.ClCCl.NCCNc1ccc2[nH]ncc2c1.O.c1ccc(OCC2CO2)cc1>>OC(CNCCNc1ccc2[nH]ncc2c1)COc1ccccc1",
        "output": "16"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)[C@H](CNC(=O)CNC(=O)CCCc1csc(N)n1)NS(=O)(=O)c1ccccc1.ClCCl.O=C(O)C(F)(F)F>>Nc1nc(CCCC(=O)NCC(=O)NC[C@H](NS(=O)(=O)c2ccccc2)C(=O)O)cs1",
        "output": "278"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=C(O)COc1ccc(O)cc1.O=S(=O)(O)O>>COC(=O)COc1ccc(O)cc1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=[N+]([O-])c1cc(Cl)cc(OCc2ccc(Br)cc2)c1.[Cl-].[Fe].[NH4+]>>Nc1cc(Cl)cc(OCc2ccc(Br)cc2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.O=[N+]([O-])c1cccc(Cl)c1NCCCO.[H][H].[Ni]>>Nc1cccc(Cl)c1NCCCO",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C.CC(C)=O.CC(C)O.ClCCCBr.O=C([O-])[O-].O=c1ccc2ccc(O)cc2o1.[K+].[K+]>>O=c1ccc2ccc(OCCCCl)cc2o1",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.COc1ccc(-c2cc3nncn3nc2C)cc1.ClC(Cl)Cl.ClCCl.O>>Cc1nn2cnnc2cc1-c1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.CO.ClC(Cl)Cl.O=C(n1ccnc1)n1ccnc1.c1ccc(C2CCNCC2)cc1>>CC(C)(C)c1nc(N2CCN(CCCCNC(=O)N3CCC(c4ccccc4)CC3)CC2)cc(C(F)(F)F)n1",
        "output": "734"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CCOC(C)=O.O=C([O-])O.O=[N+]([O-])c1cc(F)c(Br)c([N+](=O)[O-])c1.[Fe].[Na+]>>Nc1cc([N+](=O)[O-])cc(F)c1Br",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O=C(N[C@H]1C[C@@H](C(=O)O)N(CC2CCCCC2)C1)c1ccc2ccccc2c1O.O=S(=O)(O)O>>CCOC(=O)[C@@H]1C[C@H](NC(=O)c2ccc3ccccc3c2O)CN1CC1CCCCC1",
        "output": "536"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.COc1cc2c(Nc3cccc(C)c3)ncnc2cc1OCCBr>>COc1cc2c(Nc3cccc(C)c3)ncnc2cc1OCCN1CCOCC1",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCOc1cc(Cl)ncn1.CN(C)C=O.O=C([O-])[O-].Oc1ccccc1Cl.[Cl-].[K+].[K+].[NH4+]>>C#CCOc1cc(Oc2ccccc2Cl)ncn1",
        "output": "668"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(C)=O.Cl.c1ccc(COC2CC3(CCC4(CC3)OCCO4)C2)cc1>>O=C1CCC2(CC1)CC(OCc1ccccc1)C2",
        "output": "251"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(Nc2ccccc2CN2C(=O)c3ccccc3C2=O)CC1.CCO.NN.O>>CC(C)(C)OC(=O)N1CCC(Nc2ccccc2CN)CC1",
        "output": "418"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)Cc1ccc(Br)cc1[N+](=O)[O-].COCCOC.O=C([O-])[O-].OB(O)c1ccc(OCc2ccccc2)cc1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)Cc1ccc(-c2ccc(OCc3ccccc3)cc2)cc1[N+](=O)[O-]",
        "output": "837"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(CNc2cc(Nc3cnc(C#N)cn3)ncc2Cl)CC1.ClCCl.O=C(O)C(F)(F)F>>N#Cc1cnc(Nc2cc(NCC3CCNCC3)c(Cl)cn2)cn1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.CCOc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.COC(=O)CCc1cccc(O)c1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CCOc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCOc1cccc(CCC(=O)O)c1",
        "output": "928"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](N)C1.CCN(CC)CC.ClCCCl.ClCCl.O=C(O)[C@@H]1CC[C@@H]2CN1C(=O)N2OCc1ccccc1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)[C@@H]2CC[C@@H]3CN2C(=O)N3OCc2ccccc2)C1",
        "output": "216"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.O=C(NC1CC1)c1cc([N+](=O)[O-])n[nH]1.O=[Pt]=O>>Nc1cc(C(=O)NC2CC2)[nH]n1",
        "output": "684"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCOc1ccc(C(=O)O)cc1.CN(C)C=O.ClC(Cl)(Cl)Cl.O=S(Cl)Cl>>CCCCCCCCCCOc1ccc(C(=O)Cl)cc1",
        "output": "3"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCc1cc(C(C)=O)c(O)cc1OCCCCC#N.[Pd]>>CCc1cc(C(C)=O)c(O)cc1OCCCCCN",
        "output": "246"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)[C@H]1CCNC1.Cc1ccc(N2CCN(C(=O)c3ccc(N4CC(C(=O)O)CC4=O)cc3)CC2)c(C)c1>>Cc1ccc(N2CCN(C(=O)c3ccc(N4CC(C(=O)N5CC[C@H](N(C)C)C5)CC4=O)cc3)CC2)c(C)c1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.N#CCCCCc1c(-c2cccnc2)[nH]c2ccccc12.[Cl-].[Cl-].[Li+].[N-]=[N+]=[N-].[NH4+].[Na+]>>c1cncc(-c2[nH]c3ccccc3c2CCCCc2nnn[nH]2)c1",
        "output": "366"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCBr.CN(C)C=O.O=C(O)c1c[nH]c2ccccc12.[H-].[Na+]>>CCCCCn1cc(C(=O)O)c2ccccc21",
        "output": "470"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Clc1ccc(Cl)c(-c2nc3ccccc3[nH]2)n1.N>>Nc1ccc(Cl)c(-c2nc3ccccc3[nH]2)n1",
        "output": "388"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CC(=O)O.CO.ClCCl.O=CCC(c1ccccc1)n1cc(Br)cn1>>Brc1cnn(C(CCN2CCOCC2)c2ccccc2)c1",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=[N+]([O-])c1cc(C(c2ccc(O)c([N+](=O)[O-])c2)(C(F)(F)F)C(F)(F)F)ccc1O>>Nc1cc(C(c2ccc(O)c(N)c2)(C(F)(F)F)C(F)(F)F)ccc1O",
        "output": "204"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1cc2ncc3c(c2cc1O)n(-c1ccc(C#N)cc1F)c(=O)n3C.O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1cc2ncc3c(c2cc1OS(=O)(=O)C(F)(F)F)n(-c1ccc(C#N)cc1F)c(=O)n3C",
        "output": "843"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.CCOC(C)=O.COc1cc2c(cc1OC)-c1cc(Cl)nc(=O)n1CC2.Cc1cc(C)c(O)c(C)c1.ClCCl.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(cc1OC)-c1cc(Oc3c(C)cc(C)cc3C)nc(=O)n1CC2",
        "output": "668"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.CON=C1CN(Cc2ccccc2)CC12CN(C)C2.[H][H].[Pd]>>CON=C1CNCC12CN(C)C2",
        "output": "84"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)N1CCC(OC(c2ccccc2)c2ccccc2)CC1.O.[Na+].[OH-]>>c1ccc(C(OC2CCNCC2)c2ccccc2)cc1",
        "output": "283"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)Cn1c(C)cc(-c2ccccc2C(C)C)c(C(C)=O)c1=O.[Na+].[OH-]>>CC(=O)c1c(-c2ccccc2C(C)C)cc(C)n(CC(=O)O)c1=O",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Clc1ccc(Cl)cc1.O=C(Cl)c1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(c1ccccc1)c1cc(Cl)ccc1Cl",
        "output": "61"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cc1cccc(CBr)c1B1OC(C)(C)C(C)(C)O1.Cc1ccccc1N.O.O=C([O-])[O-].[K+].[K+]>>Cc1ccccc1NCc1cccc(C)c1B1OC(C)(C)C(C)(C)O1",
        "output": "272"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=C[C@@H]1C[C@]1(N)C(=O)NS(=O)(=O)C1(CCC)CC1.CC(C)(C)OC(=O)N1C[C@]2(C[C@H]1C(=O)O)C(C)(C)C21CCC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F>>C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@]2(CN1C(=O)OC(C)(C)C)C(C)(C)C21CCC1)C(=O)NS(=O)(=O)C1(CCC)CC1",
        "output": "131"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CON(C)C(=O)C1(C(F)(F)F)CCC(=O)CC1.Cl.O.[BH4-].[Na+]>>CON(C)C(=O)C1(C(F)(F)F)CCC(O)CC1",
        "output": "91"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CCCCCCN.COc1ccc(C=O)cc1.[BH4-].[Na+]>>C=CCCCCCNCc1ccc(OC)cc1",
        "output": "468"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)C1CCN(c2cccnc2)C1=O.O.O.[Li]O>>O=C(O)C1CCN(c2cccnc2)C1=O",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1cnc(N2CCNCC2)c(C2CC2)c1.Cl.O=C(O)c1ccc(I)cc1F>>Cc1cnc(N2CCN(C(=O)c3ccc(I)cc3F)CC2)c(C2CC2)c1",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)C12CC3CC(C1)C(C(C)=O)(C3)C2.Cc1ccc(S(=O)(=O)O)cc1.O=C([O-])O.OCCO.[Na+].c1ccccc1>>COC(=O)C12CC3CC(C1)C(C1(C)OCCO1)(C3)C2",
        "output": "265"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(=O)Nc1cccc(C2CCNCC2)c1.O=C(CCCCCl)c1ccccc1F>>CCC(=O)Nc1cccc(C2CCN(CCCCC(=O)c3ccccc3F)CC2)c1",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[O-].CCOC(C)=O.CI.CN(C)C1(c2cccs2)CCC2(CC1)CNC(=O)C2.CN(C)C=O.[K+]>>CN1CC2(CCC(c3cccs3)(N(C)C)CC2)CC1=O",
        "output": "83"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CS(C)=O.N#Cc1cc(NCc2cccc(F)c2)nc(-c2cc(F)ncc2Cl)c1.N[C@H]1CC[C@H](N)CC1>>N#Cc1cc(NCc2cccc(F)c2)nc(-c2cc(N[C@@H]3CC[C@@H](N)CC3)ncc2Cl)c1",
        "output": "810"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C[C@@H](/C=C\\[C@H](C[C@H](O[Si](C)(C)C(C)(C)C)[C@H](C)/C=C/COC(c1ccccc1)(c1ccccc1)c1ccccc1)O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](C)C[C@@H](C)CO[Si](C)(C)C(C)(C)C.F.c1ccncc1.c1ccncc1>>C[C@@H](/C=C\\[C@H](C[C@H](O[Si](C)(C)C(C)(C)C)[C@H](C)/C=C/COC(c1ccccc1)(c1ccccc1)c1ccccc1)O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](C)C[C@@H](C)CO",
        "output": "708"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.CC1(CO)CCCN(CC2COc3ccccc3O2)C1.ClCCl.O.c1ccncc1>>CC(=O)OCC1(C)CCCN(CC2COc3ccccc3O2)C1",
        "output": "254"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCNC(=O)n1nc(Oc2ncc(C(F)(F)F)cc2Cl)cc1C.ClCCl.O.O=C1CCC(=O)N1Br>>CCNC(=O)n1nc(Oc2ncc(C(F)(F)F)cc2Cl)c(Br)c1C",
        "output": "620"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NC1CNC1.CCCc1nc(Br)sc1C(=O)OCC.CCN(C(C)C)C(C)C>>CCCc1nc(N2CC(NC(=O)OC(C)(C)C)C2)sc1C(=O)OCC",
        "output": "657"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C[O-].Cc1csc(Nc2nccc3ccc(Cl)nc23)n1.O.O=S1(=O)CCCC1.[Na+]>>COc1ccc2ccnc(Nc3nc(C)cs3)c2n1",
        "output": "433"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "B.C1CCOC1.CCCCCCCNC(=O)Cc1ccc(Cl)cc1.CSC.Cl>>CCCCCCCNCCc1ccc(Cl)cc1",
        "output": "112"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCCCCC.CCOCC.COC(=O)CS(=O)(=O)Nc1ccc(F)cc1C(F)(F)F.Cl.[Na+].[OH-]>>O=C(O)CS(=O)(=O)Nc1ccc(F)cc1C(F)(F)F",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1Oc2cc(O)ccc2N(C)C1=S.CS(C)=O.Fc1cc(C(F)(F)F)cc(Cl)c1F.O.O=C([O-])[O-].[K+].[K+]>>CC1Oc2cc(Oc3c(F)cc(C(F)(F)F)cc3Cl)ccc2N(C)C1=S",
        "output": "564"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(N)CC.CCN(C(C)C)C(C)C.CCO.Clc1ncc(Br)c(Cl)n1>>CCC(CC)Nc1nc(Cl)ncc1Br",
        "output": "110"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.CN(C)C=O.Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1>>CC(=O)Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1",
        "output": "394"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)SCc1ccnc(C)c1.N#N>>Cc1cc(CS)ccn1",
        "output": "90"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(=O)Nc1nc(C)c(-c2ccc(S(=O)(=O)Cl)cc2)s1.CCO.CN.O=C([O-])[O-].[Na+].[Na+]>>CNS(=O)(=O)c1ccc(-c2sc(NC(C)=O)nc2C)cc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1cccc(-c2nc(O)cc(-c3ccccc3Cl)n2)n1.Cc1ccccc1.O=C([O-])[O-].O=P(Cl)(Cl)Cl.[Na+].[Na+]>>Cc1cccc(-c2nc(Cl)cc(-c3ccccc3Cl)n2)n1",
        "output": "168"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)c1ccc(C(=O)O)cc1.CN1CCOCC1.COc1nc(Cl)nc(OC)n1.ClCCl.NCc1ccccc1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>CC(C)(C)c1ccc(C(=O)NCc2ccccc2)cc1",
        "output": "753"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.O=C([O-])[O-].O=[N+]([O-])c1ccc(OC2CCNCC2)c(Br)c1.OC(c1ccc(CBr)cc1)(C(F)(F)F)C(F)(F)F.[K+].[K+]>>O=[N+]([O-])c1ccc(OC2CCN(Cc3ccc(C(O)(C(F)(F)F)C(F)(F)F)cc3)CC2)c(Br)c1",
        "output": "248"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC[N+](CCCC)(CCCC)Cc1ccccc1.CNCCC#N.ClCCl.Clc1ccc(C=CCBr)cc1.[Br-].[Na+].[OH-]>>CN(CC=Cc1ccc(Cl)cc1)CCC#N",
        "output": "252"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCO.CCOC(=O)c1cnc2cc(I)ccc2n1.[Na+].[OH-]>>O=C(O)c1cnc2cc(I)ccc2n1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CNCCN1.CCn1cc(C(=O)O)c(=O)c2cc(F)c(Cl)cc21.O.O.O.O.O.O.O>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)cc21",
        "output": "280"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cc1cc2c([N+](=O)[O-])cccc2c(C)n1.[Pd]>>Cc1cc2c(N)cccc2c(C)n1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.CI.Cc1cccc(-c2ccc(Cl)c(C(=O)O)c2)c1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cc(-c2cccc(C)c2)ccc1Cl",
        "output": "415"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cccc(C)c1N.O=C(Br)CBr>>Cc1cccc(C)c1NC(=O)CBr",
        "output": "442"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCCCN.O=C1c2ccccc2C(=O)N1Cc1cnc(OCC(F)(F)C(F)F)c(Cl)c1>>NCc1cnc(OCC(F)(F)C(F)F)c(Cl)c1",
        "output": "242"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.O=C(O)Cc1ccc(Cl)c(Cl)c1.O=C(n1ccnc1)n1ccnc1.OCC1CN(Cc2ccccc2)CCN1>>O=C(Cc1ccc(Cl)c(Cl)c1)N1CCN(Cc2ccccc2)CC1CO",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.COC(=O)c1ccccc1COc1ccc(CCN)cc1.Cl.ClCCl.O=S(=O)(Cl)Cc1ccccc1>>COC(=O)c1ccccc1COc1ccc(CCNS(=O)(=O)Cc2ccccc2)cc1",
        "output": "493"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCC.COc1ccc(S(=O)(=O)NC(=O)CNC(=O)OC(C)(C)C)cc1.Cl>>COc1ccc(S(=O)(=O)NC(=O)CN)cc1",
        "output": "431"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.Cc1csc2c(C3CCN(CCCC#N)CC3)noc12.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1csc2c(C3CCN(CCCCN)CC3)noc12",
        "output": "246"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)C(CC(C)C)c1cc(-c2ccc(C(F)(F)F)cc2)cc(C2CCCN(Cc3ccc(OC)c(C(F)(F)F)c3)C2)c1.[K+].[OH-]>>COc1ccc(CN2CCCC(c3cc(-c4ccc(C(F)(F)F)cc4)cc(C(CC(C)C)C(=O)O)c3)C2)cc1C(F)(F)F",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21.ClCCl.O=C(O)C(F)(F)F>>N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21",
        "output": "538"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(C(=O)Nc2cccc(N3CCOCC3)c2)cc1NC(=O)c1cccc(OC2CCN(C(=O)OC(C)(C)C)C2)c1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(C(=O)Nc2cccc(N3CCOCC3)c2)cc1NC(=O)c1cccc(OC2CCNC2)c1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COc1ccc(-c2cnc3c(c2)c(-c2cnn(Cc4cc(F)cc(F)c4)c2)cn3S(=O)(=O)c2ccc(C)cc2)cc1NS(C)(=O)=O.O.[Li+].[OH-]>>COc1ccc(-c2cnc3[nH]cc(-c4cnn(Cc5cc(F)cc(F)c5)c4)c3c2)cc1NS(C)(=O)=O",
        "output": "949"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.O=C1c2ccccc2C(=O)N1c1n[nH]cc1[N+](=O)[O-].[Pd]>>Nc1c[nH]nc1N1C(=O)c2ccccc2C1=O",
        "output": "628"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO.CCOC(=O)C[C@@H]1CCc2cc(OCCCN(C)c3nc(Cl)ncc3-c3ccc(OC)cc3)ccc21.O.O.[Li]O>>COc1ccc(-c2cnc(Cl)nc2N(C)CCCOc2ccc3c(c2)CC[C@H]3CC(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.Cl.ClCCl.NCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(Cl)c1cc(F)cc(F)c1>>O=C1CCC(N2C(=O)c3cccc(CNC(=O)c4cc(F)cc(F)c4)c3C2=O)C(=O)N1",
        "output": "411"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)C1Cc2ccc(Cl)c(Cl)c2O1.O.O=S(=O)(O)Cl.O=S(Cl)Cl>>CCOC(=O)C1Cc2cc(S(=O)(=O)Cl)c(Cl)c(Cl)c2O1",
        "output": "182"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1c(-c2ccnc(N3CCCC3)c2)nc2cc(F)cc(F)c2c1Cl.Cc1ccccc1.Nc1cc(N2CCOCC2)cnc1N1CCOCC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1c(-c2ccnc(N3CCCC3)c2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)cnc1N1CCOCC1",
        "output": "859"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)c1ccc(Oc2ccc([N+](=O)[O-])cn2)cc1.CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.OCCO.c1ccccc1>>CC1(c2ccc(Oc3ccc([N+](=O)[O-])cn3)cc2)OCCO1",
        "output": "93"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.NCCCCCC(=O)O.O=C(Cl)OCCCl.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>O=C(O)CCCCCNC(=O)OCCCl",
        "output": "94"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)C(CC(=O)OC(C)(C)C)N1CCN(C(=O)/C=C/c2ccc(Cl)c(Cl)c2)CCC1=O.Cl.O>>COC(=O)C(CC(=O)O)N1CCN(C(=O)/C=C/c2ccc(Cl)c(Cl)c2)CCC1=O",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COC(=O)c1cc(Oc2ccc(F)cc2F)ncc1[N+](=O)[O-]>>COC(=O)c1cc(Oc2ccc(F)cc2F)ncc1N",
        "output": "269"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCC2CCNCC21.CC(C)=O.ClCCCBr.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCC2CCN(CCCCl)CC21",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[Si](C)(C)OC[C@H]1CCC(=O)N1CC(N)=O.CCOC(C)=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.ClCCl.O=C([O-])O.[Na+]>>CC(C)(C)[Si](C)(C)OC[C@H]1CCC(=O)N1CC(N)=S",
        "output": "695"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)N1c2ccc(OCCO[Si](C)(C)C(C)(C)C)cc2[C@H](Nc2nccc(C)n2)[C@@H](C)[C@@H]1C1CC1.CCCC[N+](CCCC)(CCCC)CCCC.CS(C)=O.[F-]>>CC(=O)N1c2ccc(OCCO)cc2[C@H](Nc2nccc(C)n2)[C@@H](C)[C@@H]1C1CC1",
        "output": "708"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CC(C)(O)CC(C)C.O=C(NCCCc1cccc(Br)c1)C(F)(F)F>>CC(C)CC(C)(O)C#Cc1cccc(CCCNC(=O)C(F)(F)F)c1",
        "output": "659"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CCc1c(NC(=O)C(F)(F)F)ccc(OC)c1[N+](=O)[O-].CO.ClCCl.O>>CCc1c(NC(=O)C(F)(F)F)ccc(O)c1[N+](=O)[O-]",
        "output": "402"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccccc1.C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.OC1(c2nccs2)CCC1.[H-].[I-].[Na+]>>c1ccc(COC2(c3nccs3)CCC2)cc1",
        "output": "464"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2ccsc2)cc1NC(=O)CC(=O)c1cccc(C#N)c1.ClCCl.O=C(O)C(F)(F)F>>N#Cc1cccc(C2=Nc3ccc(-c4ccsc4)cc3NC(=O)C2)c1",
        "output": "930"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)c1cc(-c2cnc[nH]2)cc(C(F)(F)F)c1.Cl>>O=C(O)c1cc(-c2cnc[nH]2)cc(C(F)(F)F)c1",
        "output": "752"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.Fc1ccc(-c2csc(N3CCNCC3)n2)c(F)c1.O.O=C(Nc1cccnn1)OCC(Cl)(Cl)Cl>>O=C(Nc1cccnn1)N1CCN(c2nc(-c3ccc(F)cc3F)cs2)CC1",
        "output": "980"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCC.CCOC(C)=O.Cc1cc(O)c(C)c(C)c1NC=O.ClCC=Cc1ccccc1>>Cc1cc(OC/C=C/c2ccccc2)c(C)c(C)c1NC=O",
        "output": "119"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cc1nc(N2CCC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)ccc1CNC(=O)OC(C)(C)C.Cl.O.[Na+].[OH-]>>Cc1nc(N2CCC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)ccc1CN",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cc1cc(N2CCC(O)CC2)cc(C)c1-c1csc(NC(=O)c2ccncc2)n1.O.[H-].[N-]=[N+]=NCCOCCOCCOCCI.[Na+]>>Cc1cc(N2CCC(OCCOCCOCCOCCN=[N+]=[N-])CC2)cc(C)c1-c1csc(NC(=O)c2ccncc2)n1",
        "output": "307"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(=O)Cl.CCN(C(C)C)C(C)C.Cl.ClCCl.NC1CSc2sccc2C1>>CCC(=O)NC1CSc2sccc2C1",
        "output": "45"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)Cc1ccc(CSCCN)o1.CSc1ncc(C(C)c2cccnc2)c(=O)[nH]1.c1ccncc1>>CC(c1cccnc1)c1cnc(NCCSCc2ccc(CN(C)C)o2)[nH]c1=O",
        "output": "101"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOCC.N#CC1c2ccccc2C=Cc2ccccc21.[Al+3].[Al+3].[Cl-].[Cl-].[Cl-].[H-].[H-].[H-].[H-].[Li+]>>NCC1c2ccccc2C=Cc2ccccc21",
        "output": "246"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.CCOCc1nc2c(N)nc3c(c2n1CCCCON)CCCC3>>CCOCc1nc2c(N)nc3c(c2n1CCCCON=C(C)C)CCCC3",
        "output": "86"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.COc1cc(C#N)ccc1F.O=C([O-])[O-].O=[Cu-].ON=Cc1ccccc1O.Oc1ccccc1.[Cs+].[Cs+]>>COc1cc(C#N)ccc1Oc1ccccc1",
        "output": "564"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CNCCNC.COc1ccc(N2CCNC(=O)CC2)c(-c2ccc(N(C)C)cc2)n1.Cc1ccccc1.Fc1ccc(Br)cc1.I[Cu]I.O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(N2CCC(=O)N(c3ccc(F)cc3)CC2)c(-c2ccc(N(C)C)cc2)n1",
        "output": "809"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O.O=C(O)C(F)(F)C1CCCC1.O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+].c1ccncc1>>O=C1CCC(N2Cc3cc(CNC(=O)C(F)(F)C4CCCC4)ccc3C2=O)C(=O)N1",
        "output": "599"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)CCCCNC(=O)C(CO)NS(=O)(=O)c1ccc(Cl)cc1.CS(=O)(=O)Cl>>COC(=O)CCCCNC(=O)C(COS(C)(=O)=O)NS(=O)(=O)c1ccc(Cl)cc1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.Nc1ccc(Br)c(Cl)c1F.O=C1CCC(=O)N1I>>Nc1c(I)cc(Br)c(Cl)c1F",
        "output": "834"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(Br)cc1C=O.N=C(NN)c1ccc(C(F)(F)F)cn1>>COc1ccc(Br)cc1-c1nc(-c2ccc(C(F)(F)F)cn2)n[nH]1",
        "output": "994"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C[C@@H](N)[C@@H](O)c1ccc(Cl)cc1.Cl.O=C(O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12>>C[C@@H](NC(=O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12)[C@@H](O)c1ccc(Cl)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C=CC[C@@](CNC)(c1ccc(Cl)c(Cl)c1)N(C)C(=O)OC(C)(C)C.O.O.O=C(O)CC(F)(F)F.On1nnc2ccccc21>>C=CC[C@@](CN(C)C(=O)CC(F)(F)F)(c1ccc(Cl)c(Cl)c1)N(C)C(=O)OC(C)(C)C",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2cccs2)cc1NC(=O)c1cnc(N2CCN(Cc3ccc(C#N)cc3)CC2)s1.ClCCl.O=C(O)C(F)(F)F>>N#Cc1ccc(CN2CCN(c3ncc(C(=O)Nc4cc(-c5cccs5)ccc4N)s3)CC2)cc1",
        "output": "782"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCO.Cc1cc(Oc2ccc(CCC(=O)N3CCN(Cc4ccc5c(c4)OCO5)CC3)cc2)ncc1[N+](=O)[O-].[C].[Pd]>>Cc1cc(Oc2ccc(CCC(=O)N3CCN(Cc4ccc5c(c4)OCO5)CC3)cc2)ncc1N",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Nc1ccccc1S(N)(=O)=O.O=C(O)c1cccc(OCc2ccc([N+](=O)[O-])cc2)c1.O=S(Cl)Cl.c1ccccc1.c1ccncc1>>NS(=O)(=O)c1ccccc1NC(=O)c1cccc(OCc2ccc([N+](=O)[O-])cc2)c1",
        "output": "50"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1nc(Cl)nc(Nc2ccc(-n3cnc(C)c3)c(OC)c2)n1.Nc1ccc(Cl)cc1>>COc1nc(Nc2ccc(Cl)cc2)nc(Nc2ccc(-n3cnc(C)c3)c(OC)c2)n1",
        "output": "592"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1cccc([C@H]2CCCN2C(=O)Nc2cccc(C#N)c2)c1.[Na+].[OH-]>>N#Cc1cccc(NC(=O)N2CCC[C@@H]2c2cccc(C(=O)O)c2)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CCN(CC)CC.ClCCl.Clc1ccc(OC2CCN(C3CCNCC3)CC2)cc1Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1cn2cc(F)ccc2n1.O=C([O-])O.[Na+]>>O=C(c1cn2cc(F)ccc2n1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1",
        "output": "729"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(Br)cc1.ClCCl.O=C(Cl)c1ccc([N+](=O)[O-])cc1Cl.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Bi+3]>>COc1ccc(Br)cc1C(=O)c1ccc([N+](=O)[O-])cc1Cl",
        "output": "61"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC12CCC(C1)C(C)(C)C2NC(=O)c1nc(-c2ccccc2)n2c1CNCC2.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O=C(O)C1CC1.On1nnc2ccccc21>>CC12CCC(C1)C(C)(C)C2NC(=O)c1nc(-c2ccccc2)n2c1CN(C(=O)C1CC1)CC2",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)CBr.CCS(=O)(=O)c1ccc(-c2cc(Cl)ccc2O)c(Cl)c1>>CCOC(=O)COc1ccc(Cl)cc1-c1ccc(S(=O)(=O)CC)cc1Cl",
        "output": "123"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cl.O.O=[N+]([O-])c1cccc([N+](=O)[O-])c1Cl.[Na+].[OH-]>>Nc1cccc(N)c1Cl",
        "output": "204"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)[C@H](CNC(=O)c1ccc(Cl)s1)NS(=O)(=O)c1cccc(-c2ccncc2)c1OC.Cl.[Na+].[OH-]>>COc1c(-c2ccncc2)cccc1S(=O)(=O)N[C@@H](CNC(=O)c1ccc(Cl)s1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br.CC(=O)O.COc1ccc(-c2cc3c(C)cccn3c2)cc1>>Cc1cccn2cc(-c3ccc(O)cc3)cc12",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cc(-c3cc(-c4ccc(C(F)(F)F)cc4)ccc3OCc3ccccc3)ccn2)CC1.CCO.[OH-].[OH-].[Pd+2]>>CC(C)(C)OC(=O)N1CCN(c2cc(-c3cc(-c4ccc(C(F)(F)F)cc4)ccc3O)ccn2)CC1",
        "output": "23"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c(F)c1.Oc1cccnc1.[K+].[K+]>>O=[N+]([O-])c1ccc(Oc2cccnc2)c(F)c1",
        "output": "845"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)CSc1ccc(Cl)cn1.Cl.O.O.[Li]O>>O=C(O)CSc1ccc(Cl)cn1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "FC(F)(F)c1ccc(-c2cc(CCl)on2)c(C(F)(F)F)c1.c1ccc(-c2nc3cn[nH]cc-3n2)nc1>>FC(F)(F)c1ccc(-c2cc(Cn3cc4nc(-c5ccccn5)nc-4cn3)on2)c(C(F)(F)F)c1",
        "output": "997"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)O.O.O=[N+]([O-])c1ccccc1-c1nncs1.[Cl-].[Fe].[NH4+]>>Nc1ccccc1-c1nncs1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1ccccc1.ClP(Cl)Cl.O=C(O)Cc1ccc(Cl)cc1>>O=C(Cc1ccc(Cl)cc1)c1ccc(Br)cc1",
        "output": "435"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C[O-].Clc1cccc(Cl)c1CBr.O.OCCO.[Na+]>>OCCOCc1c(Cl)cccc1Cl",
        "output": "464"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.O=C(O)COc1ccc([C@@H]2CCC(=O)C2)cc1>>CC(C)(C)OC(=O)N1CCC(NC(=O)COc2ccc([C@@H]3CCC(=O)C3)cc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.O.O=C(CBr)c1cnc(-c2ccccc2)nc1.O=C(O)Cc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+]>>O=C(Cc1ccccc1)OCC(=O)c1cnc(-c2ccccc2)nc1",
        "output": "523"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccccc1.O=C(Cl)CCBr.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(CCBr)c1ccc(Br)cc1",
        "output": "31"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO[C@@H](Cc1c(C)cc(O)cc1C)C(=O)OC.Cc1cc(-c2nc(CCl)c(C)o2)ccc1F.O=C([O-])[O-].[Cs+].[Cs+].[I-].[K+]>>CCO[C@@H](Cc1c(C)cc(OCc2nc(-c3ccc(F)c(C)c3)oc2C)cc1C)C(=O)OC",
        "output": "760"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)Cn1ncc2c1CN=C(c1ccccc1)c1cc(Cl)ccc1-2.N>>NC(=O)Cn1ncc2c1CN=C(c1ccccc1)c1cc(Cl)ccc1-2",
        "output": "163"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(-c2ncccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CN)n1.Fc1ccc(C(F)(F)F)cn1>>Cc1ccc(-c2ncccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ccc(C(F)(F)F)cn2)n1",
        "output": "810"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1ccc(CCl)cn1.Cc1cc(C(O)(C(C)c2ccc(O)cc2Cl)C(F)(F)F)ccn1>>CCOC(=O)c1ccc(COc2ccc(C(C)C(O)(c3ccnc(C)c3)C(F)(F)F)c(Cl)c2)cn1",
        "output": "678"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccccc1.CC#N.O=C([O-])[O-].Oc1ccc(Nc2ccccc2)cc1.[Cs+].[Cs+]>>c1ccc(COc2ccc(Nc3ccccc3)cc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCOC(C)=O.CO.Cc1nc(-c2ccc(Cl)c([N+](=O)[O-])c2)c(Cl)n1C(F)F.O.[Fe]>>Cc1nc(-c2ccc(Cl)c(N)c2)c(Cl)n1C(F)F",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C)OB(c2cnc(N)nc2)OC1(C)C.CNC(=O)C1CCN(Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1>>CNC(=O)C1CCN(Cc2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)CC1",
        "output": "973"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.O=C(NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1)Nc1ccc(CO)c(F)c1>>O=Cc1ccc(NC(=O)NCc2cc(C(F)(F)F)nn2-c2cccc(Cl)c2)cc1F",
        "output": "179"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O.O=[N+]([O-])c1cccc(Cl)c1Nc1ccccc1.[Cl-].[Fe].[NH4+]>>Nc1cccc(Cl)c1Nc1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccnc(-c4cnc5c(c4)c(C)cn5C)c3)sc2c1-c1ccc(Cl)cc1.CO.[Na+].[OH-]>>Cc1cc2nc(-c3ccnc(-c4cnc5c(c4)c(C)cn5C)c3)sc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)CNCc2cc([N+](=O)[O-])ccc21.CCBr.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCN1Cc2cc([N+](=O)[O-])ccc2C(C)(C)C1",
        "output": "722"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCON.CCc1cc2c(=O)n(CC(=O)c3ccc(F)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c2s1.Cl.Cl.ClC(Cl)Cl.O.c1ccncc1>>CCON=C(Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c1=O)c1ccc(F)cc1",
        "output": "212"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1nc2c(C)cc(C)nc2n1-c1ccc(CCNC(=O)Oc2ccccc2)cc1.NS(=O)(=O)c1cc2ccccc2s1>>CCc1nc2c(C)cc(C)nc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2cc3ccccc3s2)cc1",
        "output": "690"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(C(=O)O)n(C)n1.Cc1nc(C(=O)N2[C@H]3C[C@H]3C[C@H]2CN)c(-c2cccc(F)c2)s1>>Cc1cc(C(=O)NC[C@@H]2C[C@@H]3C[C@@H]3N2C(=O)c2nc(C)sc2-c2cccc(F)c2)n(C)n1",
        "output": "816"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.COC(=O)Cl.C[C@@H](c1ccc(C2CCNCC2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O.ClCCl>>COC(=O)N1CCC(c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)CC1",
        "output": "219"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCN(CC)CC.CN.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1ccccc1S(=O)(=O)NCc1cc(=O)c(OCc2ccccc2)c(C(=O)O)n1C.Cl.F[P-](F)(F)(F)(F)F>>CNC(=O)c1c(OCc2ccccc2)c(=O)cc(CNS(=O)(=O)c2ccccc2C)n1C",
        "output": "137"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=CCBr.CC(C)=O.COC(=O)Cc1cccc(O)c1.O=C([O-])[O-].[K+].[K+]>>C=CCOc1cccc(CC(=O)OC)c1",
        "output": "77"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCO.CCc1nn2c(-c3c(C)cc(C)cc3OC)ccc(OC)c2c1[N+](=O)[O-].O.[Zn]>>CCc1nn2c(-c3c(C)cc(C)cc3OC)ccc(OC)c2c1N",
        "output": "628"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1cc(-c2csc(CNC(=O)OCc3ccccc3)n2)cc(C(C)(C)C)c1O.CO.[K+].[OH-]>>CC(C)(C)c1cc(-c2csc(CN)n2)cc(C(C)(C)C)c1O",
        "output": "574"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Cl.CC(C)S(=O)(=O)NC1CCCC1(O)c1ccc(OCCN)cc1.CCN(CC)CC.ClCCl>>CC(=O)NCCOc1ccc(C2(O)CCCC2NS(=O)(=O)C(C)C)cc1",
        "output": "45"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)O.Cl.NCCNc1ccc(C(=O)Nc2ccc(Cl)cc2N)cn1.O.Oc1cccc2[nH]nnc12.[Cl-].[Na+]>>Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCCNc1ccc(C(=O)Nc2ccc(Cl)cc2N)cn1",
        "output": "674"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cn(C2CCCCC2)c2nc(S(C)(=O)=O)ncc2c1=O.NCCCN1CCOCC1>>CCOC(=O)c1cn(C2CCCCC2)c2nc(NCCCN3CCOCC3)ncc2c1=O",
        "output": "629"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCN1.CC(C)(C)c1ccc(C(=O)NCc2ccc(-c3ncnc4[nH]c(C(=O)O)cc34)cc2F)cc1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F>>CC(C)(C)c1ccc(C(=O)NCc2ccc(-c3ncnc4[nH]c(C(=O)N5CCOCC5)cc34)cc2F)cc1",
        "output": "605"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cn1c(N2CCNCC2)nc2ccccc21.O=C(NCc1ccc(F)cc1)C1(CCCCBr)c2ccccc2-c2ccccc21>>Cn1c(N2CCN(CCCCC3(C(=O)NCc4ccc(F)cc4)c4ccccc4-c4ccccc43)CC2)nc2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)O.CCOC(C)=O.Cl.Clc1ncc(Cl)c(NCC2CCOCC2)n1.Cn1cc(N)cn1>>Cn1cc(Nc2ncc(Cl)c(NCC3CCOCC3)n2)cn1",
        "output": "992"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(C(C)C)C(C)C.CN(C)c1ccncc1.Cc1ccccc1.Nc1nc(N2CCC[C@@H](C(=O)N3CCCC3)C2)ccc1[N+](=O)[O-].O=C(O)C1(n2cc(Cl)cn2)CC1>>O=C([C@@H]1CCCN(c2ccc([N+](=O)[O-])c(NC(=O)C3(n4cc(Cl)cn4)CC3)n2)C1)N1CCCC1",
        "output": "368"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)[Si](O)(c1cccc(C(=O)O)c1)C(C)C.ClCCCl.ClCCl.O=C(NCc1cccc(C2CCNCC2)c1)C(F)(F)F.On1nnc2ccccc21>>CC(C)[Si](O)(c1cccc(C(=O)N2CCC(c3cccc(CNC(=O)C(F)(F)F)c3)CC2)c1)C(C)C",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN=C=NCCCN(C)C.CCOc1cccc(C(=O)CCC(=O)O)c1.Nc1cc(-c2ccccc2)c(Cc2ccccc2)s1.O.On1nnc2ccccc21>>CCOc1cccc(C(=O)CCC(=O)Nc2cc(-c3ccccc3)c(Cc3ccccc3)s2)c1",
        "output": "882"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#C[C@]1(O)CCN(C)C1=O.CCOC(=O)c1nc(-c2cccc(Br)c2)nc2c1cnn2C>>CCOC(=O)c1nc(-c2cccc(C#C[C@]3(O)CCN(C)C3=O)c2)nc2c1cnn2C",
        "output": "659"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[Si](C)(C)OCCN(CCc1c[nH]c2ccccc12)Cc1ccc(C#CCNC(=O)COCc2ccc(F)cc2)cc1.CCO>>O=C(COCc1ccc(F)cc1)NCC#Cc1ccc(CN(CCO)CCc2c[nH]c3ccccc23)cc1",
        "output": "708"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C[C@]1(F)COC(N)=N[C@]1(C)c1cc(N)ccc1F.N#Cc1ccc(C(=O)O)nc1>>C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2ccc(C#N)cn2)ccc1F",
        "output": "985"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=Cc1cc(CNC(=O)OC(C)(C)C)cc(C(F)(F)F)c1NS(C)(=O)=O.ClCCl.O=C(O)C(F)(F)F>>C=Cc1cc(CN)cc(C(F)(F)F)c1NS(C)(=O)=O",
        "output": "793"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.N[C@H]1CCc2ccccc2C1>>CC(=O)N[C@H]1CCc2ccccc2C1",
        "output": "339"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN(C(=O)OC(C)(C)C)[C@@H](C)[C@H](N=[N+]=[N-])c1cc(C(F)(F)F)cc(C(F)(F)F)c1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN[C@@H](C)[C@H](N=[N+]=[N-])c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "887"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN1CCCOc2ccc(N)cc21.CNC(=O)c1cc(-c2cnn(C)c2)cc(F)c1Nc1nc(Cl)ncc1Cl>>CCN1CCCOc2ccc(Nc3ncc(Cl)c(Nc4c(F)cc(-c5cnn(C)c5)cc4C(=O)NC)n3)cc21",
        "output": "907"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1=C(c2ccn3c(-c4ccnc(-c5ccccc5)c4)cnc3c2)CCNC1.CO.[Pd]>>c1ccc(-c2cc(-c3cnc4cc(C5CCNCC5)ccn34)ccn2)cc1",
        "output": "806"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCCCCCC(=O)N1C[C@H](O)C[C@H]1C(=O)N1CCC[C@H]1C(=O)OC.CO.O.[Na+].[OH-]>>CCCCCCCCCC(=O)N1C[C@H](O)C[C@H]1C(=O)N1CCC[C@H]1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C(CCCCCBr)NC/C=C\\COc1cc(CN2CCCCC2)ccn1.OCCS>>O=C(CCCCCSCCO)NC/C=C\\COc1cc(CN2CCCCC2)ccn1",
        "output": "185"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1ccc(SC(F)(F)F)cc1.O=C1OC(=O)C2=C1CCCC2>>O=C1C2=C(CCCC2)C(=O)N1c1ccc(SC(F)(F)F)cc1",
        "output": "410"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCN(S(=O)(=O)c2ccc(Cl)c([N+](=O)[O-])c2)CC1.CO.C[O-].[Na+]>>COc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1[N+](=O)[O-]",
        "output": "57"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCn1c(=O)n(Cc2ccccc2F)c(=O)c2[nH]c(Cc3ccc(N)cc3)nc21.Cc1c(Cl)cccc1S(=O)(=O)Cl>>CCCCn1c(=O)n(Cc2ccccc2F)c(=O)c2[nH]c(Cc3ccc(NS(=O)(=O)c4cccc(Cl)c4C)cc3)nc21",
        "output": "68"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cn1c(I)c(I)c(I)c1I.COCCOCCOCCOCCOCCOCCOCCN>>COCCOCCOCCOCCOCCOCCOCCNC(=O)Cn1c(I)c(I)c(I)c1I",
        "output": "64"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1ccc(-c2ccc(OCC3CCN(CC4(C(F)(F)F)CCCC4)CC3)nc2)cc1.O.O=C(O)c1ccc(-c2ccc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)cc2)cc1.[Li]O>>O=C(O)c1ccc(-c2ccc(OCC3CCN(CC4(C(F)(F)F)CCCC4)CC3)nc2)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C#Cc2cc(Cl)ncc2Cl)CC1.CS(=O)(=O)c1ccc(B(O)O)c(F)c1>>CC(C)(C)OC(=O)N1CCC(C#Cc2cc(-c3ccc(S(C)(=O)=O)cc3F)ncc2Cl)CC1",
        "output": "865"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)C1CC(=O)N(Cc2ccc(OC)cc2)C1C.[BH4-].[Li+]>>COc1ccc(CN2C(=O)CC(CO)C2C)cc1",
        "output": "225"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=C(O)CCCCCBr.OCc1ccccc1>>O=C(CCCCCBr)OCc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CNCCN1.CCO.COC(=O)c1cnc(Cl)s1.O=C([O-])O.[Na+]>>COC(=O)c1cnc(N2CCNCC2)s1",
        "output": "558"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCI.CCOCC.CC[O-].CCn1cc(C)c2ccccc21.CN(C)C=O.O.[Na+].[OH-]>>CCn1cc(C)c2cc(C=O)ccc21",
        "output": "239"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=C(C)CCl.COc1cc(Cl)ccc1O.OCC1Cc2cc(Cl)cc(C3CCCCC3)c2O1.[H-].[Na+]>>C=C(C)COc1ccc(Cl)cc1OC",
        "output": "119"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.Cc1cc(C(C)(C)C#N)cc(F)c1C(=O)O.O=C(n1ccnc1)n1ccnc1.[NH4+].[OH-]>>Cc1cc(C(C)(C)C#N)cc(F)c1C(N)=O",
        "output": "358"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.COC(=O)CCC(C)C1CCC2C3C(O)CC4CC(OCCN)CCC4(C)C3CC(O)C12C.O=C(O)Cc1ccc(O)cc1.On1nnc2ccccc21>>COC(=O)CCC(C)C1CCC2C3C(O)CC4CC(OCCNC(=O)Cc5ccc(O)cc5)CCC4(C)C3CC(O)C12C",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.CCCCCCCCCCOc1ccc(C(=O)c2cccc(C(=O)OCC)c2)cc1Cc1nnn[nH]1.O.[Li+].[OH-]>>CCCCCCCCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1Cc1nnn[nH]1",
        "output": "5"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COCC#Cc1cc(Cl)c(N)c2c1OCO2.COc1cc2c(Cl)ncnc2cc1OCCCCl.C[Si](C)(C)[N-][Si](C)(C)C.[Na+]>>COCC#Cc1cc(Cl)c(Nc2ncnc3cc(OCCCCl)c(OC)cc23)c2c1OCO2",
        "output": "352"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.Cc1ccc(C(=O)Cl)cc1.Cc1ccccc1.OC1CCN(Cc2cccc(Cl)c2)CC1>>Cc1ccc(C(=O)OC2CCN(Cc3cccc(Cl)c3)CC2)cc1",
        "output": "51"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C[C@H](N)c1ccc(C(F)(F)F)cc1F.O=C(O)Cn1nnc2ccccc2c1=O>>C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F",
        "output": "599"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCC(C(=O)O)CC1.COc1c(NC(=O)c2cc3cccc(CN4CCNCC4)c3n2C)cc(C(C)(C)C)cc1NS(C)(=O)=O.F[B-](F)(F)F.O>>COc1c(NC(=O)c2cc3cccc(CN4CCN(C(=O)C5CCN(C)CC5)CC4)c3n2C)cc(C(C)(C)C)cc1NS(C)(=O)=O",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)Nc1ccc(O)cc1.CC(C)(C)[O-].CS(C)=O.O.O=[N+]([O-])c1cc(F)cc(F)c1.[K+]>>CC(=O)Nc1ccc(Oc2cc(F)cc([N+](=O)[O-])c2)cc1",
        "output": "564"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN.O=C(O)[C@H]1CC[C@@H](n2nncc2-c2ccc(Br)cc2)C1>>CCNC(=O)[C@H]1CC[C@@H](n2nncc2-c2ccc(Br)cc2)C1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cc(Cl)c(O)c(Cl)c1>>CC(C)(C)OC(=O)Nc1cc(Cl)c(O)c(Cl)c1",
        "output": "735"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCCBr.CCOc1ccc(C(=O)CCC(=O)Nc2cc(-c3ccc(O)cc3)c3ccccc3n2)cc1OCC.CN(C)C=O.O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CCOc1ccc(C(=O)CCC(=O)Nc2cc(-c3ccc(OCCNC(=O)OC(C)(C)C)cc3)c3ccccc3n2)cc1OCC",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C=CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(N)[C@H]2SC1.CC(C)OC(C)C.CCOC(C)=O.CN(C)C=O.C[N+](C)=CCl.C[Si](C)(C)CC(N)=O.Cl.O.O=CNc1nc(C(=NOCc2ccccn2)C(=O)O)cs1.O=P(Cl)(Cl)Cl.[Cl-]>>C=CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)C(=NOCc3ccccn3)c3csc(NC=O)n3)[C@H]2SC1",
        "output": "587"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(Oc2ccc(C(=O)O)c(C(F)(F)F)c2)CC1.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(CO)c(C(F)(F)F)c2)CC1",
        "output": "72"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.Cc1ccc(C(=O)Cl)cc1.Cl.Cl.ClCCl.NCCCSc1ccncc1>>Cc1ccc(C(=O)NCCCSc2ccncc2)cc1",
        "output": "271"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C1(c2ccc(Br)cn2)CCC2(CC1)OCCO2.O=C(O)C(F)(F)F>>CCOC(=O)C1(c2ccc(Br)cn2)CCC(=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=O.CO.COc1ccc(S(=O)(=O)n2ccc3cc(Cl)ccc32)cc1N1CCNCC1.[BH3-]C#N.[Na+]>>COc1ccc(S(=O)(=O)n2ccc3cc(Cl)ccc32)cc1N1CCN(C)CC1",
        "output": "217"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.Cc1nc(-c2ccc([C@H]3CNCCO3)cc2)no1.Cl.Cn1c(Cl)nc(-c2ccncn2)cc1=O>>Cc1nc(-c2ccc([C@H]3CN(c4nc(-c5ccncn5)cc(=O)n4C)CCO3)cc2)no1",
        "output": "36"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCc1cccnc1.O.O=C(O)c1ccc(OCc2ccc3cc(F)ccc3n2)cc1C1(c2ccccc2)CCC1>>O=C(NCc1cccnc1)c1ccc(OCc2ccc3cc(F)ccc3n2)cc1C1(c2ccccc2)CCC1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1cccc([N+](=O)[O-])c1Br.ClCCl>>O=[N+]([O-])c1cccc(O)c1Br",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCC(=O)c1cc(OC)cc(OC)c1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.OCCO>>CCCCCCC1(c2cc(OC)cc(OC)c2)OCCO1",
        "output": "93"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1cc(I)ccc1Cl.Cl.ClCCl.O=C([O-])O.[Na+]>>Oc1cc(I)ccc1Cl",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.O=C(O)c1ccc(O)c(F)c1.O=S(Cl)Cl>>CCOC(=O)c1ccc(O)c(F)c1",
        "output": "33"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(Cc1csc(NC(=O)NCc2cccc(F)c2)n1)C(=O)c1cc(Cl)nnc1Cl.CO.O.O=C([O-])O.[K+].[Na+].[OH-]>>COc1cc(C(=O)N(C)Cc2csc(NC(=O)NCc3cccc(F)c3)n2)c(Cl)nn1",
        "output": "407"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C=Cc1cc(=O)c(C(=O)O)cn1-c1ccc(O)cc1C.CCOCC.Cl>>Cc1cc(O)ccc1-n1cc(C(=O)O)c(=O)cc1C=CC(=O)O",
        "output": "122"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(=O)c1cc2cc(Br)ccc2n1-c1ccc(OC2CCCC2)cc1>>CCOC(=O)c1cc2cc(B3OC(C)(C)C(C)(C)O3)ccc2n1-c1ccc(OC2CCCC2)cc1",
        "output": "942"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1cc(F)c(NS(=O)(=O)c2ccco2)cc1F.Cl.[Na+].[OH-]>>O=C(O)c1cc(F)c(NS(=O)(=O)c2ccco2)cc1F",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC(Nc2ccccc2Br)CC1.CI.CN(C)C=O.[H-].[Na+]>>CN(c1ccccc1Br)C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "377"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)[C@@H](N)CC(N)=O.Cl.O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1>>CC(C)[C@H](CC(N)=O)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1",
        "output": "137"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN.CO.COC(=O)COC1CCN(Cc2ccccc2)CC1.Cl.Cl.O=C(O)COC1CCN(Cc2ccccc2)CC1>>CCNC(=O)COC1CCN(Cc2ccccc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C=O)c1cccc(C(=O)O)c1.CC(C)=O.CI.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cccc(C(C)(C)C=O)c1",
        "output": "415"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[O-].COCCO.COCCOC.Nc1nc(Cl)nc2c1ncn2C1CCCCO1.[Na+]>>COCCOc1nc(N)c2ncn(C3CCCCO3)c2n1",
        "output": "213"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C(CC)Cc1ccc(OC(C)(C)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C.[Na+].[OH-]>>CCC(Cc1ccc(OC(C)(C)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.O=C(O)c1ccc(-c2ccc(O)cc2)cc1.O=S(=O)(O)O>>CCOC(=O)c1ccc(-c2ccc(O)cc2)cc1",
        "output": "33"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cnc(Oc2ccc(Cl)cc2)s1.Cl.[Li+].[OH-]>>O=C(O)c1cnc(Oc2ccc(Cl)cc2)s1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)NCCn1c(C)ccc1C.CN(C)C=O.COCCOC.O.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>CC(=O)NCCn1c(C)cc(C=O)c1C",
        "output": "266"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)c1ccccc1.O=Cc1ccc(-c2ccccc2)cc1>>O=C(C=Cc1ccc(-c2ccccc2)cc1)c1ccccc1",
        "output": "295"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COc1ccc(Cl)c(CC(=O)O)c1.O=S(=O)(O)O>>COC(=O)Cc1cc(OC)ccc1Cl",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#Cc1cccc(NC(=O)N2CCN(c3ccccc3)C2=O)c1.CC(=O)Nc1ccc(C#Cc2cccc(NC(=O)N3CCN(c4ccccc4)C3=O)c2)cn1.O=[N+]([O-])c1ncccc1Br>>O=C(Nc1cccc(C#Cc2cccnc2[N+](=O)[O-])c1)N1CCN(c2ccccc2)C1=O",
        "output": "719"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)NC(C)C.CCOC(=O)c1ccc(-c2ccc(OCCOS(C)(=O)=O)cc2)cc1.CN(C)C=O.C[C@H](N)[C@H](O)c1ccc(O)cc1>>CCOC(=O)c1ccc(-c2ccc(OCCN[C@@H](C)[C@H](O)c3ccc(O)cc3)cc2)cc1",
        "output": "559"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C=Cc1cnc(C)c2c1COC(C)(C)O2.CO.[K+].[OH-]>>Cc1ncc(C=CC(=O)O)c2c1OC(C)(C)OC2",
        "output": "122"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(Br)cc(N2CCN(Cc3ccc(OC)c(OC)c3)C(C(N)=O)C2)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1cc(Br)cc(N2CCN(Cc3ccc(OC)c(OC)c3)C(CN)C2)c1",
        "output": "490"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.Cc1cc(F)ccc1-c1nc(S(C)(=O)=O)nc2c1ccc(=O)n2-c1c(F)cccc1F.NC1CCCCC1>>Cc1cc(F)ccc1-c1nc(NC2CCCCC2)nc2c1ccc(=O)n2-c1c(F)cccc1F",
        "output": "629"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CNC1CN(C(=O)C2CCN(C(=O)C3(C)CC3)CC2)CC1c1ccc(Cl)c(Cl)c1.O=C(O)[C@H]1CC[C@@H](O)CC1>>CN(C(=O)[C@@H]1CC[C@H](O)CC1)C1CN(C(=O)C2CCN(C(=O)C3(C)CC3)CC2)CC1c1ccc(Cl)c(Cl)c1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(C(C)C)C(C)C.CN(C)C=O.Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)O)n1.c1cnn(C2CCNCC2)n1>>Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCC(n3nccn3)CC2)n1",
        "output": "811"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "N#Cc1ccccc1C(=O)O.O=C(NCCC1CC1)c1ccc(N2CCNCC2)nn1>>N#Cc1ccccc1C(=O)N1CCN(c2ccc(C(=O)NCCC3CC3)nn2)CC1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc(C(=O)c2ccccc2)c(Br)cn1.Cl.ClCCl.c1ccncc1>>O=C(c1ccccc1)c1cc(=O)[nH]cc1Br",
        "output": "758"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#CCCCO.CCOCC.Cc1ccc(S(=O)(=O)Cl)cc1.[K+].[OH-]>>C#CCCCOS(=O)(=O)c1ccc(C)cc1",
        "output": "197"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(C(=O)Cc2ccc(SC)cc2)cc1F.NO>>COc1ccc(C(Cc2ccc(SC)cc2)=NO)cc1F",
        "output": "212"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCN1.CC(C)O.FC(F)(F)c1ccn(-c2cc(Cl)nc3ccccc23)n1>>FC(F)(F)c1ccn(-c2cc(N3CCOCC3)nc3ccccc23)n1",
        "output": "220"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CI.CN(C)C=O.O=C([O-])[O-].O=C1CCc2cc(O)c(O)cc21.[Li+].[Li+]>>COc1cc2c(cc1O)C(=O)CC2",
        "output": "62"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Brc1cncc(Br)c1.C1CCNC1>>Brc1cncc(N2CCCC2)c1",
        "output": "597"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)/C=C/C(=O)c1nn(-c2cccc(OC(F)(F)F)c2)ccc1=O.Cc1cccc(NN)c1C>>Cc1cccc(-n2nccc2-c2nn(-c3cccc(OC(F)(F)F)c3)ccc2=O)c1C",
        "output": "984"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.Cc1nc2c3c(nn2c(C)c1Cl)CN(C(=O)c1ccccc1OCC1CCNC1)C3.ClCCl.O=CO.[Na+]>>Cc1nc2c3c(nn2c(C)c1Cl)CN(C(=O)c1ccccc1OCC1CCN(C(C)C)C1)C3",
        "output": "187"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)C1=C(c2ccnn2C(C)C)CCCC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)n1nccc1C1=C(CO)CCCC1",
        "output": "150"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=C1CCOCC1c1ccc(Cl)cc1.[BH4-].[Na+]>>OC1CCOCC1c1ccc(Cl)cc1",
        "output": "91"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)C(Cc1ccccc1)NC(=O)c1cccnc1.O.[Li+].[OH-]>>O=C(NC(Cc1ccccc1)C(=O)O)c1cccnc1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCC.CO.Cc1ccc(N)c(C#C[Si](C)(C)C)c1.O.O=C([O-])[O-].[K+].[K+]>>C#Cc1cc(C)ccc1N",
        "output": "337"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "NCc1ccccc1.O=C(Cl)C1(CCCCBr)c2ccccc2-c2ccccc21>>O=C(NCc1ccccc1)C1(CCCCBr)c2ccccc2-c2ccccc21",
        "output": "206"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COC(=O)CCN(C(=O)c1cc(Cl)cc(OC)c1)C(C)C.Cl.[Na+].[OH-]>>COc1cc(Cl)cc(C(=O)N(CCC(=O)O)C(C)C)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)COc1cc(C)c(-c2nc3ccc(C(=O)Nc4ccc5ccccc5n4)cc3[nH]2)c(C)c1.Cl.[Na+].[OH-]>>Cc1cc(OCC(=O)O)cc(C)c1-c1nc2ccc(C(=O)Nc3ccc4ccccc4n3)cc2[nH]1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccccc1-c1cccc(-c2cccc(-c3ccccc3OC)n2)n1.Cl.ClC(Cl)Cl.O.c1ccncc1>>Oc1ccccc1-c1cccc(-c2cccc(-c3ccccc3O)n2)n1",
        "output": "20"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCc1nc2c(Cl)nc3ccccc3c2n1CC1CC(c2ccccc2)=NO1.CO.ClC(Cl)Cl.ClCCl.N>>CCOCc1nc2c(N)nc3ccccc3c2n1CC1CC(c2ccccc2)=NO1",
        "output": "682"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(COC1CCNCC1)N1CCCC1.O=C(O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F>>O=C(COC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1)N1CCCC1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(-c2sc(C)nc2C(=O)O)cc1.O=C(NC[C@H]1NC[C@H]2C[C@H]21)c1ccc(F)cc1>>Cc1ccc(-c2sc(C)nc2C(=O)N2C[C@H]3C[C@H]3[C@H]2CNC(=O)c2ccc(F)cc2)cc1",
        "output": "747"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.CI.O=c1c2ccc(Br)cc2nc2n1CCNC2>>CN1CCn2c(nc3cc(Br)ccc3c2=O)C1",
        "output": "483"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.CS(=O)(=O)OCCCCC1CC1.O.[N-]=[N+]=[N-].[Na+]>>[N-]=[N+]=NCCCCC1CC1",
        "output": "322"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.CNC(=O)c1c(C)n(C)c2cc(Oc3ccnc4cc(C(=O)N5CCC(OC)C5)sc34)ccc12>>CNC(=O)c1c(C)n(C)c2cc(Oc3ccnc4cc(C(=O)N5CCC(O)C5)sc34)ccc12",
        "output": "423"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)[C@@H]1C[Si](C)(C)CN1C(=O)OC(C)(C)C.Cl.O.O.[Li+].[OH-]>>CC(C)(C)OC(=O)N1C[Si](C)(C)C[C@H]1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccccc1.NCCCCn1ccnc1.O=C=Nc1ccccc1Cl>>O=C(NCCCCn1ccnc1)Nc1ccccc1Cl",
        "output": "35"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(C)=O.NCCCc1ccncc1.O>>CC(C)(C)OC(=O)NCCCc1ccncc1",
        "output": "631"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.COc1ccc2nc(Cl)c(C#N)c(-c3cccc(F)c3)c2c1.NC[C@H](O)CO>>COc1ccc2nc(NC[C@H](O)CO)c(C#N)c(-c3cccc(F)c3)c2c1",
        "output": "70"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=O.CC1CN(C(=O)OC(C)(C)C)CC(C)N1.CO.O.[BH4-].[Cl-].[Na+].[Na+]>>CC1CN(C(=O)OC(C)(C)C)CC(C)N1C",
        "output": "217"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(-c2ccccc2)nc2c1[nH]c1cc(C(=O)OC(C)C)ccc12.Cl.[Na+].[OH-]>>CC(C)OC(=O)c1ccc2c(c1)[nH]c1c(C(=O)O)cc(-c3ccccc3)nc12",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCC1CC(=O)Nc2cc(OCCCCBr)ccc21.CN(C)C=O.Cl.Clc1cccc(N2CCNCC2)c1Cl.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)NCC1CC(=O)Nc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccc21",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)c1ccc(CN)cc1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl.O.O.O=C(O)c1cc(F)cnc1Cl.On1nnc2ccccc21>>CC(C)(C)OC(=O)c1ccc(CNC(=O)c2cc(F)cnc2Cl)cc1",
        "output": "790"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Clc1ccc(OC2CCNC2)nc1.O=C(Nc1ccccc1OCC1CO1)c1ccccc1>>O=C(Nc1ccccc1OCC(O)CN1CCC(Oc2ccc(Cl)cn2)C1)c1ccccc1",
        "output": "76"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1CCN(c2nccc(N)c2[N+](=O)[O-])CC1.CO.[Pd]>>CN1CCN(c2nccc(N)c2N)CC1",
        "output": "269"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)S(=O)(=O)NC1CCCCC1O.CCN(CC)CC.ClCCl.O>>CC(C)S(=O)(=O)NC1CCCCC1=O",
        "output": "87"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1cn2cccc2cn1.ClCCl.O=C1CCC(=O)N1Br>>CCOC(=O)c1cn2c(Br)ccc2cn1",
        "output": "779"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCc1cn(Cc2cc(OCC)cc(OCc3csc(-c4cnccn4)n3)c2)cc1-c1ccccc1.Cl.[Na+].[OH-]>>CCOc1cc(Cn2cc(CCC(=O)O)c(-c3ccccc3)c2)cc(OCc2csc(-c3cnccn3)n2)c1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.CCOC(=O)n1c(C(=O)c2cncnc2)c(N)c2ccc(Cl)cc21>>CCOC(=O)n1c(C(=O)c2cncnc2)c(NC(C)=O)c2ccc(Cl)cc21",
        "output": "422"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CCN(CC)CC.CO.Cc1cc2nc(NC(=O)NC3CCCCC3)cnc2n1COCC[Si](C)(C)C.Cl.NCCN.O>>Cc1cc2nc(NC(=O)NC3CCCCC3)cnc2[nH]1",
        "output": "981"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CC2(CCN1)OCCO2.O.O=[N+]([O-])c1ccccc1F.c1ccncc1>>O=[N+]([O-])c1ccccc1N1CCC2(CC1)OCCO2",
        "output": "26"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.COC(=O)CCc1cn2ccccc2n1.Cl.[BH4-].[Ca+2].[Cl-].[Cl-].[Na+]>>OCCCc1cn2ccccc2n1",
        "output": "343"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN.O=C(O)COc1ccc(OCc2ccccc2)cc1.O=C(n1ccnc1)n1ccnc1>>CNC(=O)COc1ccc(OCc2ccccc2)cc1",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccc(Br)nc1.CC#N.CC(=O)O[Pd]OC(C)=O.CO.O.O=C([O-])[O-].OB(O)c1ccc(F)cc1F.[K+].[K+].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Fc1ccc(-c2ccc(Br)cn2)c(F)c1",
        "output": "869"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCS(=O)(=O)Cl.CCN(CC)CC.ClCCl.O=C(NCCOC1CCCCO1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1N(CCO)CCBr.O=C([O-])O.[Na+]>>CCCCS(=O)(=O)OCCN(CCBr)c1c(C(=O)NCCOC2CCCCO2)cc([N+](=O)[O-])cc1[N+](=O)[O-]",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CNCCN1.COc1ccc(Br)cc1C.Fc1cc(Br)ccc1OCc1ccccc1>>Fc1cc(N2CCNCC2)ccc1OCc1ccccc1",
        "output": "294"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)C1CC1.CCO.O.O=Cc1ccc(OCc2ccccc2)cc1.[Na+].[OH-]>>O=C(/C=C/c1ccc(OCc2ccccc2)cc1)C1CC1",
        "output": "656"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCN(C(=O)/C=C/C(=O)OCC)c1ccc(Cl)cc1C(=O)c1cccc(OC)c1OC.CCO.CCOC(C)=O.[BH4-].[Na+]>>C=CCN(C(=O)/C=C/C(=O)OCC)c1ccc(Cl)cc1C(O)c1cccc(OC)c1OC",
        "output": "157"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)Cc1ccc(-c2ccc(C(CC3CCOCC3)c3ccc(S(=O)(=O)C4CC4)cc3)[nH]2)nc1.O.[BH4-].[Li+]>>O=S(=O)(c1ccc(C(CC2CCOCC2)c2ccc(-c3ccc(CCO)cn3)[nH]2)cc1)C1CC1",
        "output": "343"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=S(Cl)Cl.OCc1cc(F)ccc1Sc1ccccc1.c1ccccc1>>Fc1ccc(Sc2ccccc2)c(CCl)c1",
        "output": "81"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CNc1ccc(Br)cc1[N+](=O)[O-].Cl[Sn]Cl.O.O.[K+].[OH-]>>CNc1ccc(Br)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O=Cc1ccc(CO)cc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCc1ccc(C=O)cc1",
        "output": "193"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCCC(=O)N(C(=O)OC(C)(C)C)c1ccc(F)cc1C.FCc1cccc(Br)n1>>Cc1cc(F)ccc1N(C(=O)CCC#Cc1cccc(CF)n1)C(=O)OC(C)(C)C",
        "output": "777"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)[C@H]1NCSC1C(=O)CC1CCc2ccccc2C1.[Na+].[OH-]>>O=C(CC1CCc2ccccc2C1)C1SCN[C@@H]1C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CSc1ccc([N+](=O)[O-])cc1Cl.O.[Fe]>>CSc1ccc(N)cc1Cl",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COc1ncc(F)cc1CNc1ccc(CO)cn1.[Na+].[Na+].[O-]S([O-])=S>>COc1ncc(F)cc1CNc1ccc(C=O)cn1",
        "output": "520"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.CCOC(C)=O.Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C3(N)CCC3)s2)c1>>CC(=O)NC1(c2ncc(-c3cc(C)cc(Nc4nccc(C(F)(F)F)n4)c3)s2)CCC1",
        "output": "45"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)c1cnc(N2CC(F)(F)C2)cn1.Cl.O.O.[Li+].[OH-]>>O=C(O)c1cnc(N2CC(F)(F)C2)cn1",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1=COCCC1.COC(=O)CNC(=O)CC(O)CBr.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.c1cc[nH+]cc1>>COC(=O)CNC(=O)CC(CBr)OC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCCC(=O)N[C@@H](CC(=O)SC)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>C=CCCC(=O)N[C@@H](CC(=O)SC)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)N1CC2(CCNCC2)c2ccccc21.Cl.ClC(Cl)Cl.O=C(Nc1cnc(-c2ccccc2)cn1)Oc1ccccc1>>CS(=O)(=O)N1CC2(CCN(C(=O)Nc3cnc(-c4ccccc4)cn3)CC2)c2ccccc21",
        "output": "525"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(F)cc1C(=O)O.O=S(=O)(O)O.O=[N+]([O-])O>>Cc1c(C(=O)O)cc(F)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccccc1.Nc1ccccc1>>c1ccc(Nc2ccccc2)cc1",
        "output": "405"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CNC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1cnc(Cl)c(Cl)c1>>O=C(c1cnc(Cl)c(Cl)c1)N1CCC1",
        "output": "256"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OC(C)(C)C)cc1)C(=O)O.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CN1CCOCC1.COC(=O)[C@@H](N)CCCNC(=N)N.F[P-](F)(F)(F)(F)F>>COC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)OC(C)(C)C",
        "output": "129"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)COc1ccc(Sc2ccc(COc3ccc(C(F)(F)F)cc3)cc2Cl)c2c1CCCC2.Cc1cc(Sc2ccc(COc3ccc(C(F)(F)F)cc3)cc2)ccc1OCC(=O)O>>O=C(O)COc1ccc(Sc2ccc(COc3ccc(C(F)(F)F)cc3)cc2Cl)c2c1CCCC2",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)O.Cc1cc([N+](=O)[O-])c(Cl)nc1Cl.N.O=C([O-])[O-].[K+].[K+]>>Cc1cc([N+](=O)[O-])c(N)nc1Cl",
        "output": "388"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NS(=O)(=O)c1ccc2c(c1)CC(=O)N2.O=Cc1ccc2[nH]ccc2c1>>NS(=O)(=O)c1ccc2c(c1)C(=Cc1ccc3[nH]ccc3c1)C(=O)N2",
        "output": "439"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C(C)(C)c1ccc([N+](=O)[O-])c(Cl)c1.CO.[K+].[OH-]>>CC(C)(C(=O)O)c1ccc([N+](=O)[O-])c(Cl)c1",
        "output": "615"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.Nc1ccc(Cl)cc1F.O=C(O)CC(F)(F)F>>O=C(CC(F)(F)F)Nc1ccc(Cl)cc1F",
        "output": "365"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CCN(CC)CC.CCOC(=O)CCCCl.CCOCC.CN(C)C=O.O=C([O-])O.[Na+]>>CCOC(=O)CCCN1CCCCC1",
        "output": "138"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)c1nc2c(C#C[Si](C)(C)C)c(N)ccc2c(=O)n1-c1ccc(Cl)cc1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>C#Cc1c(N)ccc2c(=O)n(-c3ccc(Cl)cc3)c(C(C)C)nc12",
        "output": "337"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CCBr.CC#N.Cc1c(C2CCNCC2)cccc1S(C)(=O)=O.O=C([O-])[O-].[K+].[K+]>>C=CCN1CCC(c2cccc(S(C)(=O)=O)c2C)CC1",
        "output": "252"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCNCCC.CCN(CC)CC.CCOC(=O)Cl.ClC(Cl)Cl.O=C(O)c1cc2ccccc2c(-c2ccccc2Cl)n1>>CCCN(CCC)C(=O)c1cc2ccccc2c(-c2ccccc2Cl)n1",
        "output": "605"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "FC(F)(F)c1nnc2ccc(N3CCNCC3)nn12.O=Cc1ccc2nccnc2c1>>FC(F)(F)c1nnc2ccc(N3CCN(Cc4ccc5nccnc5c4)CC3)nn12",
        "output": "567"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2ccc(F)cc2)cc1[N+](=O)[O-].[Ni]>>CC(C)(C)OC(=O)Nc1ccc(-c2ccc(F)cc2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CC[C@@H](Nc2cccc3nc(Nc4ccc(C(N)=O)cc4)nn23)CC1.CCO.O.O=C([O-])[O-].OO.[Cl-].[Na+].[Na+].[Na+]>>NC(=O)c1ccc(Nc2nc3cccc(N[C@H]4CC[C@@H](N)CC4)n3n2)cc1",
        "output": "538"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCNc1ncc(-c2nc(-c3ccc4c(c3)CCN(C(=O)OC(C)(C)C)CC4)no2)cc1C#N.ClCCl.O=C(O)C(F)(F)F>>CCCNc1ncc(-c2nc(-c3ccc4c(c3)CCNCC4)no2)cc1C#N",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.CCCCCCCCOc1ccc(Br)cc1.[Li]CCCC>>CCCCCCCCOc1ccc(B(O)O)cc1",
        "output": "832"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[C@H](C)CCCCn1c(=O)c2c(N(C)C)cc(C)nc2n(C)c1=O.CO.O.[K+].[OH-]>>Cc1cc(N(C)C)c2c(=O)n(CCCC[C@@H](C)O)c(=O)n(C)c2n1",
        "output": "325"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Clc1ncccc1-n1cccc1.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>O=Cc1cccn1-c1cccnc1Cl",
        "output": "641"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)c1cc(F)c(NS(=O)(=O)c2ccc(-c3cnc(C4CCOCC4)nc3)cc2)cc1F.Cl.[Li+].[OH-]>>O=C(O)c1cc(F)c(NS(=O)(=O)c2ccc(-c3cnc(C4CCOCC4)nc3)cc2)cc1F",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CNCC(O)(CNC(=O)c1cnn(-c2ccc(F)cc2)c1N)C(F)(F)F.O=C(Cl)c1c(Cl)cccc1Cl>>CN(CC(O)(CNC(=O)c1cnn(-c2ccc(F)cc2)c1N)C(F)(F)F)C(=O)c1c(Cl)cccc1Cl",
        "output": "201"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CS(=O)(=O)Cl.Nc1ccc(Br)c(F)c1.c1ccncc1>>CS(=O)(=O)Nc1ccc(Br)c(F)c1",
        "output": "194"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CCC2=NO.Cc1ccc(C(=O)O)cc1.ClCCl>>Cc1ccc(C(=O)O[C@H]2CC[C@@]3(C)C(=CC[C@H]4[C@@H]5CCC(=NO)[C@@]5(C)CC[C@@H]43)C2)cc1",
        "output": "33"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.CO.Cl.ClC(Cl)Cl.O=C(n1ccnc1)n1ccnc1.c1ccc(C2CCCNCC2)cc1>>CC(C)(C)c1nc(N2CCN(CCCCNC(=O)N3CCCC(c4ccccc4)CC3)CC2)cc(C(F)(F)F)n1",
        "output": "734"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCc1ccc(-c2ccnc(C(F)(F)F)c2)cc1.O=C(O)c1ccc(-c2cnccn2)cc1>>O=C(NCc1ccc(-c2ccnc(C(F)(F)F)c2)cc1)c1ccc(-c2cnccn2)cc1",
        "output": "753"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NC1CCN(CCc2c(Cl)cnc3ccc4c(c23)OCCO4)CC1.ClCCl.O=C(O)C(F)(F)F>>NC1CCN(CCc2c(Cl)cnc3ccc4c(c23)OCCO4)CC1",
        "output": "538"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCI.Cc1cccnc1C(=O)CCc1coc(-c2ccc(O)c(OC(F)F)c2)n1>>CCOc1ccc(-c2nc(CCC(=O)c3ncccc3C)co2)cc1OC(F)F",
        "output": "198"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C(CCc1ccccc1)NN(C)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C.CCOCC.Cl>>CCOC(=O)C(CCc1ccccc1)NN(C)C(=O)N1CCC[C@H]1C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)c1nc(OC2CCCCC2)c(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)n1.OCc1ccc(F)c(F)c1.[Li]CCCC>>Fc1ccc(COc2nc(OC3CCCCC3)c(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)n2)cc1F",
        "output": "667"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(B(O)O)c(OC)c1.Fc1cccc(-c2nc3cnn(Cc4ccc(Cl)nn4)cc-3n2)c1F>>COc1ccc(-c2ccc(Cn3cc4nc(-c5cccc(F)c5F)nc-4cn3)nn2)c(OC)c1",
        "output": "866"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(CNCC(=O)Nc2cccc(Cl)c2)cc1OC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1ccc(CNCCNc2cccc(Cl)c2)cc1OC",
        "output": "112"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCS(=O)(=O)N1CC[C@](CC(=O)O)(c2ccc(-c3ccc(CC)cc3)s2)S(=O)(=O)CC1.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CO.Cl.ClC(Cl)Cl.NOC1CCCCO1.On1nnc2ccccc21>>CCCS(=O)(=O)N1CC[C@](CC(=O)NOC2CCCCO2)(c2ccc(-c3ccc(CC)cc3)s2)S(=O)(=O)CC1",
        "output": "480"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CO.Cl.ClCCl.Cn1cc(C2CCNCC2)c2cc(NC(=O)c3cc(C#N)ccn3)ccc21.O.O=C(O)C1CCCC1.On1nnc2ccccc21>>Cn1cc(C2CCN(C(=O)C3CCCC3)CC2)c2cc(NC(=O)c3cc(C#N)ccn3)ccc21",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)N[C@@H]1CCCC[C@H]1NS(=O)(=O)c1ccc(C)cc1.CCOCC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCN[C@@H]1CCCC[C@H]1NS(=O)(=O)c1ccc(C)cc1",
        "output": "112"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.COc1cccc(Sc2ccc(C#N)cc2)c1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>COc1cccc(Sc2ccc(CN)cc2)c1",
        "output": "175"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(=O)(=O)c1cc(Br)ccc1C(=O)O.Cc1ccc(N2CCNCC2)c(C)c1>>Cc1ccc(N2CCN(C(=O)c3ccc(Br)cc3S(C)(=O)=O)CC2)c(C)c1",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.Cl.ClC(Cl)Cl.NC1CCN(Cc2ccc(Cl)cc2)C1.O.O=C(O)CNC(=O)c1ccccc1.On1nnc2ccccc21>>O=C(CNC(=O)c1ccccc1)NC1CCN(Cc2ccc(Cl)cc2)C1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)c1ccc2c(c1)C(C)(C)CCO2.CO.[BH4-].[Cl-].[Na+].[Na+]>>CC(O)c1ccc2c(c1)C(C)(C)CCO2",
        "output": "24"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.COC(=O)CBr.NC(=O)c1cccc2c1c1c(O)cccc1n2Cc1ccccc1C(F)(F)F>>COC(=O)COc1cccc2c1c1c(C(N)=O)cccc1n2Cc1ccccc1C(F)(F)F",
        "output": "557"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)Cc1ccc(Nc2ncnc(Cl)c2[N+](=O)[O-])cc1.[Ni]>>CCOC(=O)Cc1ccc(Nc2ncnc(Cl)c2N)cc1",
        "output": "660"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.CN1CCOCC1.Cc1cc(N)[nH]n1.ClCCl.O>>CC(=O)Nc1cc(C)n[nH]1",
        "output": "527"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2c1CCC(C)(C)C2.O.[Na+].[OH-]>>CC1(C)CCc2c(O)nc3oc4c(NCCN5CCOCC5)ncnc4c3c2C1",
        "output": "408"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCCc1ccc(NC(=O)NC2(CC(=O)OCC)CCN(C(=O)OCc3ccccc3)C2)cc1.CCO.[Pd]>>CCCCCCCCc1ccc(NC(=O)NC2(CC(=O)OCC)CCNC2)cc1",
        "output": "428"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Cc1ccc(C=O)c(C)c1.Fc1ccc(Br)cc1.Fc1ccc(Br)cc1.II.[Cl-].[Mg].[NH4+]>>Cc1ccc(C(O)c2ccc(F)cc2)c(C)c1",
        "output": "379"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(F)c(B(O)O)c1F.COc1cccc(N(C)C(=O)c2ccc(Br)s2)c1.[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cccc(N(C)C(=O)c2ccc(-c3c(F)ccc(OC)c3F)s2)c1",
        "output": "864"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc(C2COCCN2)nc1.C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cl.Cl.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCOCC1c1ccc(Br)cn1",
        "output": "694"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1cccc(-c2nc3ccc(C(=O)O)cc3o2)c1.O=C(O)c1ccc2c(c1)C(=O)OC2=O>>O=C(O)c1ccc2c(c1)C(=O)N(c1cccc(-c3nc4ccc(C(=O)O)cc4o3)c1)C2=O",
        "output": "475"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CN(C)C=O.Cc1cccc(N)c1.ClCCCl.N#Cc1ccc(-c2cc(N3CCC[C@H](C(=O)O)C3)nc(N)n2)cc1F.O.On1nnc2ccccc21>>Cc1cccc(NC(=O)[C@H]2CCCN(c3cc(-c4ccc(C#N)c(F)c4)nc(N)n3)C2)c1",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(NCCC1CCN(c2ccncc2)CC1)c1cccc(N2Cc3cccc(Cl)c3C2=O)c1.O=C(O)c1cccc(N2Cc3cccc(Cl)c3C2=O)c1.c1ccc(N2CCNCC2)nc1>>O=C(c1cccc(N2Cc3cccc(Cl)c3C2=O)c1)N1CCN(c2ccccn2)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CCn1cc(C(O)(c2ccc3c(cnn3-c3ccc(F)cc3)c2)C(F)(F)F)cc1C(=O)OCC.CCO.O.[Cl-].[NH4+].[Na+].[OH-]>>C=CCn1cc(C(O)(c2ccc3c(cnn3-c3ccc(F)cc3)c2)C(F)(F)F)cc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.C[Si](C)(C)C=[N+]=[N-].O=C(O)c1ccccc1-n1nc2c3ccccc3n(Cc3ccc(-n4cccn4)cc3)cc-2c1=O>>COC(=O)c1ccccc1-n1nc2c3ccccc3n(Cc3ccc(-n4cccn4)cc3)cc-2c1=O",
        "output": "195"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCBr.CC(C)=O.O=C([O-])[O-].Oc1ccc2[nH]ccc2c1.[K+].[K+]>>C=CCOc1ccc2[nH]ccc2c1",
        "output": "77"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CS(C)=O.O=[N+]([O-])c1ccc(F)cc1>>CC(C)(C)OC(=O)N1CCC(Nc2ccc([N+](=O)[O-])cc2)CC1",
        "output": "572"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cl.Nc1ncnc2c1c(I)nn2C1CCNC1.O.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N1CCC(n2nc(I)c3c(N)ncnc32)C1",
        "output": "694"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1nc(C#N)c2c(c1O)c(Cl)c(Cl)n2-c1ccccc1.CO.C[O-].NCC(=O)O.[Na+]>>N#Cc1nc(C(=O)NCC(=O)O)c(O)c2c(Cl)c(Cl)n(-c3ccccc3)c12",
        "output": "977"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOCC.O=C(CCl)Nc1ccc2[nH]cnc2c1.c1ccc(CC2CCNCC2)cc1>>O=C(CN1CCC(Cc2ccccc2)CC1)Nc1ccc2[nH]cnc2c1",
        "output": "340"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCc1cc(C(=O)O)nc(S(C)(=O)=O)n1.CN>>CCCc1cc(C(=O)O)nc(NC)n1",
        "output": "629"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(NC(=O)OC(C)(C)C)c1nc2ncccc2c(C(=O)O)c1-c1ccccn1.CCN(C(C)C)C(C)C.CN.CN(C)C=O.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CNC(=O)c1c(-c2ccccn2)c(C(C)NC(=O)OC(C)(C)C)nc2ncccc12",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC1CCN(c2ccc(S(=O)(=O)Nc3ncns3)cc2)CC1.Cl>>NC1CCN(c2ccc(S(=O)(=O)Nc3ncns3)cc2)CC1",
        "output": "538"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CCN.CS(C)=O.Cc1cc(C#N)cnc1F.Cl.O>>Cc1cc(C#N)cnc1NCCC(=O)OC(C)(C)C",
        "output": "810"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCOc1ccc(CCC(=O)Cl)cc1OC.NCc1ccc(F)cc1>>C#CCOc1ccc(CCC(=O)NCc2ccc(F)cc2)cc1OC",
        "output": "206"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl.O=C(Cl)C(=O)Cl>>NS(=O)(=O)c1cc(C(=O)Cl)c(NCc2ccco2)cc1Cl",
        "output": "448"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.COc1cc(C2CCCCC2)ccc1C(O)CCC(=O)O.[Pd]>>COc1cc(C2CCCCC2)ccc1CCCC(=O)O",
        "output": "447"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(S(=O)c2ccc(C)cc2-c2ccc(N)c([N+](=O)[O-])c2)c(-c2ccc(N)c([N+](=O)[O-])c2)c1.O=[N+]([O-])c1cc(S(=O)c2ccc(-c3ccc(Br)cc3)cc2)ccc1Cl>>Nc1cc(S(=O)c2ccc(-c3ccc(Br)cc3)cc2)ccc1Cl",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.O=[N+]([O-])c1ccc(-n2cnc(CO)c2)c(F)c1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCc1cn(-c2ccc([N+](=O)[O-])cc2F)cn1",
        "output": "193"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.O.O=[N+]([O-])c1ccc(OCc2ccc(F)cc2)cc1F.[Fe]>>Nc1ccc(OCc2ccc(F)cc2)cc1F",
        "output": "202"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.COc1nccc2c(-c3cc(S(C)(=O)=O)ccc3N)cn(C)c12.ClCCl.O=CC1CC1.[Na]>>COc1nccc2c(-c3cc(S(C)(=O)=O)ccc3NCC3CC3)cn(C)c12",
        "output": "336"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1cc2c3ccccc3n(-c3ccccc3)c2s1.[K+].[OH-]>>O=C(O)c1cc2c3ccccc3n(-c3ccccc3)c2s1",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(N)CN(C)C.O=C(O)c1cccc2nc3ccc4c([N+](=O)[O-])cccc4c3nc12.O=C(O)c1cccc2nc3ccc4cc([N+](=O)[O-])ccc4c3nc12>>CC(CN(C)C)NC(=O)c1cccc2nc3ccc4cc([N+](=O)[O-])ccc4c3nc12",
        "output": "674"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(N3C(=O)OC[C@H]3CO)cc2F)CC1.CCI>>CCOC[C@@H]1COC(=O)N1c1ccc(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c(F)c1",
        "output": "307"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCc1cc(C(=O)c2ccccc2Cl)c(-n2c(C)nnc2CN)s1.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccc(S(=O)(=O)O)cc1.F[P-](F)(F)(F)(F)F.O=C(O)/C=C/c1ccccc1[N+](=O)[O-]>>CCc1cc(C(=O)c2ccccc2Cl)c(-n2c(C)nnc2CNC(=O)/C=C/c2ccccc2[N+](=O)[O-])s1",
        "output": "767"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1ccc(C2CC(N)CN(C(=O)N3CCCC3)C2)cc1.O=C(O)C(F)(F)F.O=C(O)c1ccc(F)cc1>>CCc1ccc(C2CC(NC(=O)c3ccc(F)cc3)CN(C(=O)N3CCCC3)C2)cc1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN.CO.CO.N#Cc1ccc(F)cc1.O>>CNc1ccc(C#N)cc1",
        "output": "572"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)N=C=O.COC(=O)C(C)c1ccc(-c2cccc(O)c2)c(F)c1>>COC(=O)C(C)c1ccc(-c2cccc(OC(=O)NC(C)C)c2)c(F)c1",
        "output": "104"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Fc1cc(I)ccc1CBr.O.[C-]#N.[Na+]>>N#CCc1ccc(I)cc1F",
        "output": "39"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC/C=C\\CCCOc1cccc(CO)c1.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CCCCCC/C=C\\CCCOc1cccc(C=O)c1",
        "output": "179"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CC1(C)c2cc(OCC(=O)O)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21.CN(C)C=O.ClCCCl.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCN(C(=O)COc2ccc3c(c2)C(C)(C)c2[nH]c4cc(C#N)ccc4c2C3=O)CC1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1nnc2n1CCNC2.O=C(O)c1cc2ncc(Cl)cn2n1>>Cc1nnc2n1CCN(C(=O)c1cc3ncc(Cl)cn3n1)C2",
        "output": "663"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cccc(C(=O)O)c1C.NCC(c1ccncc1)N1CCOCC1>>Cc1cccc(C(=O)NCC(c2ccncc2)N2CCOCC2)c1C",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.O=Cc1cc(I)ccc1F.[BH4-].[Na+]>>OCc1cc(I)ccc1F",
        "output": "356"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1CCOCC1.COc1nc(Cl)nc(OC)n1.ClCCl.NCCN1CCCC1.O=C(O)c1ccc(Br)cn1>>O=C(NCCN1CCCC1)c1ccc(Br)cn1",
        "output": "137"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccc(Oc2ccc(C=O)cc2)cc1)C(=O)O.CCOC(C)=O.CI.CN(C)C=O.CO.ClC(Cl)Cl.O.O=C([O-])O.[Na+]>>COC(=O)[C@H](Cc1ccc(Oc2ccc(C=O)cc2)cc1)NC(=O)OC(C)(C)C",
        "output": "415"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CN(C)CC(=O)O.CS(=O)(=O)c1cccc(Br)c1.Cc1cc(O)ccc1-n1cnc2c(C(F)(F)F)cccc21.Cl.O.O=C([O-])[O-].[Cs+].[Cs+].[Cu]I>>Cc1cc(Oc2cccc(S(C)(=O)=O)c2)ccc1-n1cnc2c(C(F)(F)F)cccc21",
        "output": "238"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CCOCC.O.Oc1ccc(Br)cc1.c1ccncc1>>CC(=O)Oc1ccc(Br)cc1",
        "output": "46"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N1CCC(N)CC1.CC(C)O.CCN(CC)CC.O=C(NC[C@H](O)CN1CCc2ccccc2C1)c1cc(Cl)ncn1>>CC(=O)N1CCC(Nc2cc(C(=O)NC[C@H](O)CN3CCc4ccccc4C3)ncn2)CC1",
        "output": "166"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCC.CCOC(=O)COc1cc(C)cc(C)c1Cc1ccc(C(C)C)cc1.CCOC(C)=O>>Cc1cc(C)c(Cc2ccc(C(C)C)cc2)c(OCC(=O)O)c1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)N1CCC(Oc2ccc3c(c2)cc(C(=O)N2CCNCC2)n3CC(F)F)CC1.CCN(CC)C(=O)Cl.Cl>>CCN(CC)C(=O)N1CCN(C(=O)c2cc3cc(OC4CCN(C(C)C)CC4)ccc3n2CC(F)F)CC1",
        "output": "258"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCC[Sn](CCCC)(CCCC)c1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)cc1.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.COC(=O)[C@@H](N)Cc1ccccc1.Cl.ClCCl.On1nnc2ccccc21>>CCCC[Sn](CCCC)(CCCC)c1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)OC)cc1",
        "output": "129"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1cc(O)cc(CO)c1.CCOCC.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CC(C)c1cc(O)cc(C=O)c1",
        "output": "179"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.ClCCl.N.N#CC1(c2ccccc2)CCCCC1.[Rh]>>NCC1(c2ccccc2)CCCCC1",
        "output": "246"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.COc1ccc(Oc2c(Cl)cc(CO)cc2Cl)cc1.O.[H-].[H][H].[Na+]>>COCc1cc(Cl)c(Oc2ccc(OC)cc2)c(Cl)c1",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C(=O)Nc1nccs1)C(c1ccccc1)c1ccc2[nH]ccc2c1.CN(C)C=O.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>CC(C)(C(=O)Nc1nccs1)C(c1ccccc1)c1ccc2[nH]cc(C=O)c2c1",
        "output": "266"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1cc(N)cc(N2CCOCC2)c1.CCOCC.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Mg+2].[Na+].[OH-]>>Nc1cc(CO)cc(N2CCOCC2)c1",
        "output": "311"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NC(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1cccc(F)n1.O=C(O)C(F)(F)F>>NC(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1cccc(F)n1",
        "output": "538"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.C1CCC2=NCCCN2CC1.CCc1ccc2[nH]c(C(=O)O)cc2c1.CN(C)C=O.O>>CCc1ccc2[nH]c(C(=O)OCc3ccccc3)cc2c1",
        "output": "403"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1ccc(-n2cnc(-c3c(-c4ccccc4)noc3C(F)(F)F)c2)nc1.NC1CCOCC1>>O=C(NC1CCOCC1)c1ccc(-n2cnc(-c3c(-c4ccccc4)noc3C(F)(F)F)c2)nc1",
        "output": "862"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)Cl.CS(=O)(=O)n1ccc2c3nc(-c4ccc(N)cc4)nc(N4CCOCC4)c3ccc21>>CCOC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3ccc4c(ccn4S(C)(=O)=O)c3n2)cc1",
        "output": "102"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(CCCO)CC1.ClCCl.II.c1c[nH]cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCN(CCCI)CC1",
        "output": "670"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.COCCN.Fc1ccc(-n2ncnc2-c2cc3c(s2)-c2nc(-c4ccc(F)nc4)ccc2OCC3)c(F)c1>>COCCNc1ccc(-c2ccc3c(n2)-c2sc(-c4ncnn4-c4ccc(F)cc4F)cc2CCO3)cn1",
        "output": "810"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Clc1cc(-c2ccccc2)nc(Cl)n1.N#Cc1cccc(B(O)O)c1>>N#Cc1cccc(-c2cc(-c3ccccc3)nc(Cl)n2)c1",
        "output": "884"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1CCn2c(cc(Cl)nc2=O)N1C.N#Cc1ccc(CO)cc1>>CC1CCn2c(cc(OCc3ccc(C#N)cc3)nc2=O)N1C",
        "output": "653"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCc1cc(OCc2ccc(-c3ccccc3C(=O)OC)cc2)c2ccccc2n1.[Na+].[OH-]>>CCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CO.COC(=O)c1ccc([C@@H]2C[C@H]2N)cc1.Cl.O=C([O-])O.O=C1CCS(=O)(=O)CC1.[Na+]>>COC(=O)c1ccc([C@@H]2C[C@H]2NC2CCS(=O)(=O)CC2)cc1",
        "output": "236"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)C(Br)C1CCCCC1.NC=O.Oc1ccc(Oc2ccccc2)cc1.[Na]>>CCOC(=O)C(Oc1ccc(Oc2ccccc2)cc1)C1CCCCC1",
        "output": "455"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)N(CCO[Si](C)(C)C(C)(C)C)C(=O)c1nc(Cc2ncccc2-c2ccccc2)nc(O)c1OCc1ccccc1.CN(CCO[Si](C)(C)C(C)(C)C)C(=O)c1nc(Cc2ccccc2-c2ccccc2)nc(O)c1OCc1ccccc1.CO.ClCCl>>CC(C)N(CCO)C(=O)c1nc(Cc2ncccc2-c2ccccc2)nc(O)c1OCc1ccccc1",
        "output": "708"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1nc(N2CCCN(Cc3ccc(F)cc3)C2=O)sc1C(=O)O.Cc1nc(N2CCN(Cc3csc4ccc(Cl)cc34)C2=O)sc1C(=O)O.NCc1cccnc1>>Cc1nc(N2CCCN(Cc3ccc(F)cc3)C2=O)sc1C(=O)NCc1cccnc1",
        "output": "534"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.OCc1n[nH]c2ccc(Cl)cc12.[Mn+4].[O-2].[O-2]>>O=Cc1n[nH]c2ccc(Cl)cc12",
        "output": "573"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C1CCc2[nH]c3ccc(N)cc3c2C1.Cc1ccsc1C(=O)O>>Cc1ccsc1C(=O)Nc1ccc2[nH]c3c(c2c1)CC(N(C)C)CC3",
        "output": "822"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(O)O.CCO.CCOC(C)=O.Cc1ccccc1.O=C([O-])[O-].O=C1Cc2ccc(Br)cc2N1.OB(O)c1cccnc1.[Na+].[Na+]>>O=C1Cc2ccc(-c3cccnc3)cc2N1",
        "output": "899"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)CC1(F)CCN(C(=O)OC(C)(C)C)CC1.ClCCl.[H-]>>CC(C)(C)OC(=O)N1CCC(F)(CCO)CC1",
        "output": "225"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCc1cc2cccnc2n1S(=O)(=O)c1ccccc1.CO.[K+].[OH-]>>CCCc1cc2cccnc2[nH]1",
        "output": "831"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1c(O)cccc1CC1CCCC=C1c1nc(-c2ccccc2)c(-c2ccccc2)o1.Cc1cccc(C)n1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1c(CC2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)cccc1OS(=O)(=O)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CNCCO.CO.COC(=O)[C@@H](C)Oc1cccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(OC)c3)c12>>COc1cc(Nc2ncnc3cccc(O[C@H](C)C(=O)N(C)CCO)c23)ccc1Oc1ccc(C)nc1",
        "output": "227"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN1CC(C)(C)OC(=O)C1CC(=O)O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccccc1CN.F[P-](F)(F)(F)(F)F>>CCN1CC(C)(C)OC(=O)C1CC(=O)NCc1ccccc1C",
        "output": "599"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)CC(C)(N)C#N.O=C(O)c1cc(OCC(F)(F)F)c(Cl)cn1>>CC(C)(C)CC(C)(C#N)NC(=O)c1cc(OCC(F)(F)F)c(Cl)cn1",
        "output": "137"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1NCCn2c(-c3ccc(F)nc3)cnc21.O=C(O)c1cc2ncc(Cl)cn2n1>>CC1c2ncc(-c3ccc(F)nc3)n2CCN1C(=O)c1cc2ncc(Cl)cn2n1",
        "output": "663"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCC.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)NCC(=O)O)cc1.Cl.Cl.ClCCl.NCc1ccc(C(c2cc(F)ccc2F)S(=O)(=O)c2ccc(Cl)cc2)nc1>>Cc1ccc(S(=O)(=O)NCC(=O)NCc2ccc(C(c3cc(F)ccc3F)S(=O)(=O)c3ccc(Cl)cc3)nc2)cc1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)C(CN)C1(C)OCCO1.Cc1ccc2c(c1)C(=O)OC2=O>>COC(=O)C(CN1C(=O)c2ccc(C)cc2C1=O)C1(C)OCCO1",
        "output": "341"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(C)N.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)c1cccc(NCc2ccccc2)c1>>CC(C)NC(=O)c1cccc(NCc2ccccc2)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.Cl[Pd]Cl.O=C1CCc2c(Br)cccc21.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2cccc3c2CCC3=O)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)OCCN.CO.O=C1CCOCC1>>CC(C)(C)[Si](C)(C)OCCNC1CCOCC1",
        "output": "236"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.COc1ccc(N)cc1OC.O=C(Cl)C12CC3CC(CC(C3)C1)C2>>COc1ccc(NC(=O)C23CC4CC(CC(C4)C2)C3)cc1OC",
        "output": "134"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.CC(C)[O-].CC(C)[O-].CC(C)[O-].CN=C(SCc1ccc(OC)cc1)C1(c2cccnc2)CCCCC1CC=O.[Al+3]>>CN=C(SCc1ccc(OC)cc1)C1(c2cccnc2)CCCCC1CCO",
        "output": "223"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CSCCN.Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1Cc1ccc(C(=O)O)cc1>>CSCCNC(=O)c1ccc(Cc2c(C)nn(-c3ccc(C#N)c(Cl)c3)c2C)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCCC1=O.Nc1c(Cl)cc(O)c2c1C(=O)c1ccccc1C2=O.O=C([O-])[O-].OCCO.Oc1ccccc1.[K+].[K+]>>Nc1c(OCCO)cc(O)c2c1C(=O)c1ccccc1C2=O",
        "output": "57"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)[C@H](C)N)c1.O=C(O)c1c[nH]cn1>>COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)[C@H](C)NC(=O)c2c[nH]cn2)c1",
        "output": "697"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCl.O=C(OCc1ccccc1)N1CCN(c2ccc(O)cc2)CC1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>O=C(OCc1ccccc1)N1CCN(c2ccc(OS(=O)(=O)C(F)(F)F)cc2)CC1",
        "output": "731"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCc1ccccc1.CC#N.Cc1ccc(O)cn1.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(OCc2ccccc2)cn1",
        "output": "623"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)Oc1ccc2ccccc2c1C=O.CO.O.[BH4-].[Na+]>>CC(C)Oc1ccc2ccccc2c1CO",
        "output": "356"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1c(Cl)c(C)c(C(C)=O)c(OCCBr)c1OCCCc1ccccc1.Cl.FC1(F)CNC1>>COc1c(Cl)c(C)c(C(C)=O)c(OCCN2CC(F)(F)C2)c1OCCCc1ccccc1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC(C)(C(=O)O)c1ccc(S(=O)(=O)/C=C/C#N)cc1.CCN=C=NCCCN(C)C.CNCc1ccccc1OC.Cl.On1nnc2ccccc21>>COc1ccccc1CN(C)C(=O)C(C)(C)c1ccc(S(=O)(=O)/C=C/C#N)cc1",
        "output": "633"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "B.C1CCOC1.C1CCOC1.CCN(CC)C(=O)Cc1ccc([N+](=O)[O-])cc1Cl>>CCN(CC)CCc1ccc([N+](=O)[O-])cc1Cl",
        "output": "112"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCC.CCS.COC(=O)CC(Cc1ccc(OCc2ccccc2)cc1)c1ncc(C)s1.FB(F)F>>COC(=O)CC(Cc1ccc(O)cc1)c1ncc(C)s1",
        "output": "23"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1c(N2CC(C)(C)CC2=O)nc2cc(F)cc(F)c2c1Cl.Cc1ccccc1.Nc1cncc(N2CCOCC2)c1>>Cc1c(N2CC(C)(C)CC2=O)nc2cc(F)cc(F)c2c1Nc1cncc(N2CCOCC2)c1",
        "output": "859"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCOC(=O)c1cc(O)c2cc(C(F)(F)F)ccc2n1.COc1ccc(CCl)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)c1cc(OCc2ccc(OC)cc2)c2cc(C(F)(F)F)ccc2n1",
        "output": "49"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CN.O=C(NCCCON1C(=O)c2ccccc2C1=O)OCc1ccccc1>>NOCCCNC(=O)OCc1ccccc1",
        "output": "452"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)CCCCCN.Cl.Cl.O.O=C1Nc2ccc(F)cc2C1=Cc1ccc(C(=O)O)cc1.Oc1cccc2[nH]nnc12.[Cl-].[Na+]>>COC(=O)CCCCCNC(=O)c1ccc(C=C2C(=O)Nc3ccc(F)cc32)cc1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCC.Nc1ccc2c(c1)Cc1ccccc1-2.O=C=NCCCl>>O=C(NCCCl)Nc1ccc2c(c1)Cc1ccccc1-2",
        "output": "176"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCc1c(Br)cccc1C=C1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>CCc1c(Br)cccc1C=C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.C[C@H](N)c1ncc(F)cn1.Cc1cc(Nc2nc(Cl)ncc2Cl)n[nH]1.Cl>>Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)n[nH]1",
        "output": "544"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC1CCN(CCc2ccc(F)cc2)CC1CN.CCN(CC)CC.CCc1cc(NC(=O)Oc2ccccc2)cc(-c2nnnn2C)c1.CN(C)C=O>>CCc1cc(NC(=O)NCC2CN(CCc3ccc(F)cc3)CCC2CC)cc(-c2nnnn2C)c1",
        "output": "488"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cl[Sn]Cl.N#N.Nc1ccc(Cl)c(Oc2cc(Cl)cc(Br)c2)c1[N+](=O)[O-].O.O>>Nc1ccc(Cl)c(Oc2cc(Cl)cc(Br)c2)c1N",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CO.O=c1[nH]c2cc([N+](=O)[O-])ccc2o1.[OH-].[OH-].[Pd+2]>>Nc1ccc2oc(=O)[nH]c2c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cl.N#Cc1c(C(F)(F)F)cc(-c2ccc(Cl)cc2)nc1Cl.N#Cc1ccc(NC2CCCNC2)nc1>>N#Cc1ccc(NC2CCCN(c3nc(-c4ccc(Cl)cc4)cc(C(F)(F)F)c3C#N)C2)nc1",
        "output": "220"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.Cc1c([C@@H](O)CN2CCC3(CCNCC3)C2)ccc2c1COC2=O.N#Cc1ccc(Br)nc1.O>>Cc1c([C@@H](O)CN2CCC3(CCN(c4ccc(C#N)cn4)CC3)C2)ccc2c1COC2=O",
        "output": "647"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CI.CN(C)C=O.O.OCc1cncc(Br)c1.[H-].[Na+]>>COCc1cncc(Br)c1",
        "output": "140"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1sc2nc(-c3cnccn3)nc(Cl)c2c1Cl.NCCc1ccc2c(c1)OCCO2>>Cc1sc2nc(-c3cnccn3)nc(NCCc3ccc4c(c3)OCCO4)c2c1Cl",
        "output": "723"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CNc1nccc(Oc2ccc(O)c([N+](=O)[O-])c2)n1.CO>>CNc1nccc(Oc2ccc(O)c(N)c2)n1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCNCC.CCO.Clc1ccc(I)cn1>>CCN(CC)c1ccc(I)cn1",
        "output": "220"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC1(C)c2cnc(S(C)(=O)=O)nc2CN1C(=O)OCc1ccccc1.C[Si](C)(C)I>>CC1(C)NCc2nc(S(C)(=O)=O)ncc21",
        "output": "428"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COC(=O)c1ccc(N2CCN(CC3=C(c4ccc(Cl)cc4)CCC(O)C3)CC2)cc1Oc1ccc2[nH]ccc2c1.Cl.O.O.[Li]O>>O=C(O)c1ccc(N2CCN(CC3=C(c4ccc(Cl)cc4)CCC(O)C3)CC2)cc1Oc1ccc2[nH]ccc2c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.COc1cccc(C(=O)Cl)c1.Nc1ccn(S(=O)(=O)Cc2ccccc2)c1>>COc1cccc(C(=O)Nc2ccn(S(=O)(=O)Cc3ccccc3)c2)c1",
        "output": "501"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCc1ccccc1.C=CCN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@]24CC[C@]3(C[C@@H]2[C@@](C)(C(C)(C)C)OCO4)[C@H]1C5.CC(C)(C)[C@@]1(C)OCO[C@]23CC[C@@]4(C[C@@H]21)[C@H]1Cc2ccc(OCc5ccccc5)c5c2[C@@]4(CCN1CC1CC1)[C@H]3O5.CC(C)(C)[C@@]1(C)OCO[C@]23CC[C@@]4(C[C@H]12)[C@H]1Cc2ccc(O)c5c2[C@@]4(CCN1CC1CC1)[C@H]3O5.CI>>C=CCN1CC[C@]23c4c5ccc(OC)c4O[C@H]2[C@@]24CC[C@]3(C[C@@H]2[C@@](C)(C(C)(C)C)OCO4)[C@H]1C5",
        "output": "62"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(N)cc1-c1ccnn1C(C)C.ClCCl.O=C=Nc1ccc(C(F)(F)F)cc1Cl>>COc1ccc(NC(=O)Nc2ccc(C(F)(F)F)cc2Cl)cc1-c1ccnn1C(C)C",
        "output": "804"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CC(OCC2CC2)CCN1.CC#N.CN(C)C=O.O.O=C([O-])[O-].O=C1CCc2cc(F)c(F)cc2N1CCCCl.[I-].[K+].[K+].[Na+]>>O=C1CCc2cc(F)c(F)cc2N1CCCN1CCC(OCC2CC2)CC1",
        "output": "138"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCOc1cc(C(F)(F)F)ccc1C(=O)O.CN1CCOCC1.CNOC.COc1nc(OC)nc([N+]2(C)CCOCC2)n1.[Cl-]>>CCCOc1cc(C(F)(F)F)ccc1C(=O)N(C)OC",
        "output": "828"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Nc1ccc(Oc2ccnc(Cl)n2)c2ccccc12.COc1cc(N)cc(C(=O)O)c1.N#N>>COc1cc(Nc2nccc(Oc3ccc(NC(=O)OC(C)(C)C)c4ccccc34)n2)cc(C(=O)O)c1",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1CCCC1=O.CN1CCC[C@H]1Cc1ccc2cc[nH]c2c1.Fc1ccc(I)cc1.O=C([O-])[O-].[K+].[K+]>>CN1CCC[C@H]1Cc1ccc2ccn(-c3ccc(F)cc3)c2c1",
        "output": "267"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCc2ccc(CCI)cc2C1.CN(C)C=O.O=C([O-])[O-].O=c1cc(OCc2ccccc2)cn[nH]1.[Cs+].[Cs+]>>CC(C)(C)OC(=O)N1CCc2ccc(CCn3ncc(OCc4ccccc4)cc3=O)cc2C1",
        "output": "346"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(NC(=O)C[C@@H]1CCCNC1)c1ccccc1Cl.CCBr.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCN1CCC[C@@H](CC(=O)NC(C)(C)c2ccccc2Cl)C1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCN(C2=NC(=O)CS2)CC1CO.O=Cc1ccc2c(c1)c(I)nn2Cc1ccc(C(F)(F)F)cc1C(F)(F)F>>CC(C)(C)OC(=O)N1CCN(C2=NC(=O)C(=Cc3ccc4c(c3)c(I)nn4Cc3ccc(C(F)(F)F)cc3C(F)(F)F)S2)CC1CO",
        "output": "314"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C=CCCc1cc(F)ccc1Br.CN(C)C=O.[Li]CCCC>>C=CCCc1cc(F)ccc1C=O",
        "output": "638"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNS(=O)(=O)CCCCN.ClCCl>>CNS(=O)(=O)CCCCNC(=O)OC(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Nc1ccc(C(=O)O)cc1.O.O=N[O-].O=S(=O)(O)O.[N-]=[N+]=[N-].[Na+].[Na+]>>[N-]=[N+]=Nc1ccc(C(=O)O)cc1",
        "output": "189"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CCO.CCO.CCOC(=O)c1cc(NC2CCCC2)ncn1.COC(=O)c1cc(NC2CCCC2)ncn1.COC(=O)c1cc(NCC2CCCC2)nc(Cl)n1.O.O.[Li+].[OH-].[Pd]>>O=C(O)c1cc(NC2CCCC2)ncn1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN.CCn1c(=O)n(CC)c2cc(-c3cn(CC(=O)O)nc3-c3cccc(C)c3)ccc21.ClCCl.O=C(n1ccnc1)n1ccnc1>>CCNC(=O)Cn1cc(-c2ccc3c(c2)n(CC)c(=O)n3CC)c(-c2cccc(C)c2)n1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCNC1.CCOCC.CCn1cc(C(=O)O)c(=O)c2c(F)c(F)c(F)c(F)c21.CN1CCCC1>>CCn1cc(C(=O)O)c(=O)c2c(F)c(F)c(N3CCCC3)c(F)c21",
        "output": "676"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1cccc(I)c1.C#Cc1ccc2c(c1)CCC(OC)C2.C1CCOC1.CCN(CC)CC.Cl.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.I[Cu]I>>COC1CCc2cc(C#Cc3cccc(Br)c3)ccc2C1",
        "output": "664"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCc1cc(F)c(O)cc1OC.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCCc1cc(F)c(OS(=O)(=O)C(F)(F)F)cc1OC",
        "output": "731"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CCBr.COc1ccc(N2CCNCC2)cc1S(C)(=O)=O>>C=CCN1CCN(c2ccc(OC)c(S(C)(=O)=O)c2)CC1",
        "output": "252"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOCC.N#CCc1cc(F)ccc1Br.O.[K+].[OH-]>>NCCc1cc(F)ccc1Br",
        "output": "246"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "N=C(NN)c1ccccn1.O=Cc1cc(O)ccc1O>>Oc1ccc(O)c(-c2nc(-c3ccccn3)n[nH]2)c1",
        "output": "994"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCOCC.COCOc1ccccc1C(O)c1cccc(Cl)c1OCOC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>COCOc1ccccc1C(=O)c1cccc(Cl)c1OCOC",
        "output": "59"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Nc1cccc(-c2c(C(=O)c3ccccc3)cnc3c(C(F)(F)F)cccc23)c1.O=C(Cl)Oc1ccccc1Cl>>O=C(Nc1cccc(-c2c(C(=O)c3ccccc3)cnc3c(C(F)(F)F)cccc23)c1)Oc1ccccc1Cl",
        "output": "102"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#Cc1ccncc1.CCN(CC)CC.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.I[Cu]I.O=[N+]([O-])c1ccc(Br)c(C(F)(F)F)c1>>O=[N+]([O-])c1ccc(C#Cc2ccncc2)c(C(F)(F)F)c1",
        "output": "659"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCOc1cccc(-c2cc(CCl)on2)c1.Fc1ccccc1-c1nc2cn[nH]cc-2n1>>CCCOc1cccc(-c2cc(Cn3cc4nc(-c5ccccc5F)nc-4cn3)on2)c1",
        "output": "997"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.Cc1ccccc1.O.[Na+].[OH-].c1cnc2[nH]ccc2c1>>Cc1ccc(S(=O)(=O)n2ccc3cccnc32)cc1",
        "output": "354"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.COCCNCc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)CC(=O)Nc5cccc(S(C)(=O)=O)c5)cc4F)c3s2)nc1>>COCCN(Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)CC(=O)Nc5cccc(S(C)(=O)=O)c5)cc4F)c3s2)nc1)C(C)=O",
        "output": "369"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1=COCCC1.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.N#N.O.O=Cc1ccc(CO)o1.c1cc[nH+]cc1>>O=Cc1ccc(COC2CCCCO2)o1",
        "output": "141"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.O=C1CCC(=O)N1Br.Oc1ccnc2cc(Cl)c(I)cc12>>Oc1c(Br)cnc2cc(Cl)c(I)cc12",
        "output": "518"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COCCO[Al+]OCCOC.Cc1ccccc1.O=C(O)[C@H]1CN(Cc2ccccc2)C[C@@H]1c1ccccc1.[H-].[H-].[Na+].[Na+].[OH-]>>OC[C@H]1CN(Cc2ccccc2)C[C@@H]1c1ccccc1",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)c1ccc(B(O)O)cc1.CCOC(=O)c1ccc(-c2ccc(OCCCO[Si](C)(C)C(C)(C)C)c(Br)c2)cc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1ccc(-c2ccc(OCCCO[Si](C)(C)C(C)(C)C)c(-c3ccc(N(CC)CC)cc3)c2)cc1",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.ClCc1ccc2ccccc2n1.Oc1ccc(-c2ncoc2-c2ccncc2)cc1.[Cs+].[F-]>>c1ccc2nc(COc3ccc(-c4ncoc4-c4ccncc4)cc3)ccc2c1",
        "output": "616"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)N1CCN(CCCO)CC1.CCOC(=O)N=NC(=O)OCC.CN(C)C=O.COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)cnnc2cc1O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)cnnc2cc1OCCCN1CCN(C(C)=O)CC1",
        "output": "478"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(C2CCC(CC(=O)OC(C)(C)C)CC2)cc1.[Na+].[OH-]>>CC(C)(C)OC(=O)CC1CCC(c2ccc(C(=O)O)cc2)CC1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCO.CCOC(=O)c1ccc(N)nc1N.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cl.F[P-](F)(F)(F)(F)F.NCc1ccc(Oc2ccccc2)s1.O.[Cl-].[Na+].[Na+].[OH-]>>Nc1ccc(C(=O)NCc2ccc(Oc3ccccc3)s2)c(N)n1",
        "output": "498"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)CCCN1CCN.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.O=C(O)c1ccc(F)c(NC(=O)c2cnc3cc(Br)ccn23)c1>>CC1(C)CCCN1CCNC(=O)c1ccc(F)c(NC(=O)c2cnc3cc(Br)ccn23)c1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)[O-].FC(F)(F)c1ccnc(Cl)n1.Nc1cc(Cl)cc(Br)c1.[Cl-].[K+].[NH4+]>>FC(F)(F)c1ccnc(Nc2cc(Cl)cc(Br)c2)n1",
        "output": "808"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.Clc1nnc(Cc2ccncc2)c2ccccc12.NC1CCCC1.O=C([O-])O.[Na+]>>c1ccc2c(NC3CCCC3)nnc(Cc3ccncc3)c2c1",
        "output": "241"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cnc2ccc(Cl)nc2c1NC1CCN(C(=O)OC(C)(C)C)CC1.CO.Cl.O.[Li+].[OH-]>>CC(C)(C)OC(=O)N1CCC(Nc2c(C(=O)O)cnc3ccc(Cl)nc23)CC1",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CN(c1ccc([N+](=O)[O-])cc1F)c1ccnc2[nH]ccc12.[H][H].[Pd]>>CN(c1ccc(N)cc1F)c1ccnc2[nH]ccc12",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1sc2nc(-c3cnccn3)nc(Cl)c2c1Cl.NCc1ccc(F)cc1>>Cc1sc2nc(-c3cnccn3)nc(NCc3ccc(F)cc3)c2c1Cl",
        "output": "906"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.O.O=[N+]([O-])c1cccc2c1cnn2Cc1ccc(F)cc1F.[Cl-].[Fe].[NH4+]>>Nc1cccc2c1cnn2Cc1ccc(F)cc1F",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1ccc(S(=O)(=O)n2cc(C=O)c3ccccc32)cc1.[BH4-].[Na+]>>Cc1ccc(S(=O)(=O)n2cc(CO)c3ccccc32)cc1",
        "output": "476"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc(-c2cnn(-c3ccc(C(=O)O)cn3)c2O)ccn1.Cl.NCCC1CCCCO1>>COc1cc(-c2cnn(-c3ccc(C(=O)NCCC4CCCCO4)cn3)c2O)ccn1",
        "output": "674"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CSCCN1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN1CCCC1=O.COC(=O)C1CC(c2ccc(C(F)(F)F)c(F)c2)CN(C(=O)Oc2ccc([N+](=O)[O-])cc2)C1.O>>COC(=O)C1CC(c2ccc(C(F)(F)F)c(F)c2)CN(C(=O)N2CCSCC2)C1",
        "output": "770"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#CC(C)(O)COC.CC(C)NC(C)C.CN(C)C=O.NC(=O)c1nc2n(c1-c1nc(C3CC3)n[nH]1)CCOc1cc(F)c(Br)cc1-2>>COCC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1-c1nc(C2CC2)n[nH]1",
        "output": "659"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.ClCCl.Nc1ccc(C(F)(F)F)cc1.O=C(Cl)c1ccccc1[N+](=O)[O-].O=C([O-])O.[Na+]>>O=C(Nc1ccc(C(F)(F)F)cc1)c1ccccc1[N+](=O)[O-]",
        "output": "11"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO.O=[N+]([O-])c1ccc(Cl)c(I)c1.[Cl-].[Fe].[NH4+]>>Nc1ccc(Cl)c(I)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CO.N#Cc1cc(-c2ccccc2F)[nH]c1Cl>>N#Cc1c[nH]c(-c2ccccc2F)c1",
        "output": "40"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CCOc1ccc([C@H]2[C@H](O[Si](C(C)C)(C(C)C)C(C)C)CN(C(=O)OCc3ccccc3)C[C@@H]2O)cc1.COCCCN1C(=O)COc2ccc(CCl)cc21>>C=CCOc1ccc([C@H]2[C@H](O[Si](C(C)C)(C(C)C)C(C)C)CN(C(=O)OCc3ccccc3)C[C@@H]2OCc2ccc3c(c2)N(CCCOC)C(=O)CO3)cc1",
        "output": "208"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COC(=O)c1c(C)cccc1-c1ccc(N(CC(C)C)CC(C)C)c([N+](=O)[O-])c1.ClCCl.O.[Cl-].[NH4+].[Zn]>>COC(=O)c1c(C)cccc1-c1ccc(N(CC(C)C)CC(C)C)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.ClCCCBr>>ClCCCN1CCOCC1",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Nc1cc(Cl)nc(Cl)c1C(=O)OC(C)(C)C.CCOC(C)=O.CCOC(C)=O.Cl.[Na+].[OH-]>>CC(C)(C)OC(=O)c1c(N)cc(Cl)nc1Cl",
        "output": "782"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccncc1-c1nsnc1Cl.ClC(Cl)(Cl)Cl.O.O=C([O-])[O-].O=C1CCC(=O)N1Br.[K+].[K+]>>Clc1nsnc1-c1cnccc1CBr",
        "output": "29"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(N(C)Cc3ccccn3)nc2c1.[Na+].[OH-]>>CN(Cc1ccccn1)c1nc2cc(C(=O)O)ccc2nc1-c1ccc(F)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(=O)C1CCNCC1>>CCOC(=O)C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "694"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc2c(cc1N)CCOC(=O)N2C.NC(=O)[C@@H]1[C@H]2C=C[C@H](C2)[C@@H]1Nc1nc(Cl)ncc1Cl>>COc1cc2c(cc1Nc1ncc(Cl)c(N[C@@H]3[C@H](C(N)=O)[C@H]4C=C[C@@H]3C4)n1)CCOC(=O)N2C",
        "output": "808"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCN(CC)CC.CCNC(=O)[C@H](N)[C@H](C)O.ClCCl.On1nnc2ccccc21.[N-]=[N+]=Nc1ccc(C(=O)O)c(O)c1>>CCNC(=O)[C@H](NC(=O)c1ccc(N=[N+]=[N-])cc1O)[C@H](C)O",
        "output": "718"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCNC[C@H]1c1ccccc1.CS(=O)(=O)CCC(=O)O.Cl.Cl.O.On1nnc2ccccc21>>CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCN(C(=O)CCS(C)(=O)=O)C[C@H]1c1ccccc1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CNc1ccc(NC(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)CNc1ccc(N)cc1",
        "output": "782"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.CS(C)=O.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Oc2ccccc2)cc1.ClCCl.Nc1ccc(-n2ccc3cnccc32)c2ccccc12>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(-n3ccc4cnccc43)c3ccccc23)cc1",
        "output": "948"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.COc1cccc(CO)c1.O=C1CCC(=O)N1Br>>COc1ccc(Br)c(CO)c1",
        "output": "4"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cn1nccc1-c1ccc(F)c(OCc2ccccc2)c1.[Pd]>>Cn1nccc1-c1ccc(F)c(O)c1",
        "output": "23"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.Clc1ccc2c(n1)CCNC2.F[P-](F)(F)(F)(F)F.O=C(O)CC1CC1.On1nnc2ccccc21>>O=C(CC1CC1)N1CCc2nc(Cl)ccc2C1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Cc1cccc(NC[C@@H]2CCN(C(=O)C3CC3)C2)c1[N+](=O)[O-].[Pd]>>Cc1cccc(NC[C@@H]2CCN(C(=O)C3CC3)C2)c1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)O.F[P-](F)(F)(F)(F)F.c1cnc(N2CCNCC2)nc1>>Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ncccn2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "N[C@@H]1CCCC[C@H]1O.O=C(O)c1cnc(CCc2ccccn2)c(-c2ccc(Cl)cc2)c1>>O=C(N[C@@H]1CCCC[C@H]1O)c1cnc(CCc2ccccn2)c(-c2ccc(Cl)cc2)c1",
        "output": "674"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCc1nc(CC)n(-c2ccc(N3CCC4(CC3)OCCO4)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1nc(CC)n(-c2ccc(N3CCC4(CC3)OCCO4)cc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.ClCCl.O=C1CN(C(=O)OCc2ccccc2)CCN1Cc1cc2c(Cl)nccc2[nH]1.O=S(=O)(Cl)c1ccccc1.O=S(=O)([O-])O.[Na+].[OH-]>>O=C1CN(C(=O)OCc2ccccc2)CCN1Cc1cc2c(Cl)nccc2n1S(=O)(=O)c1ccccc1",
        "output": "648"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)C(=O)Cl.O.O=C([O-])[O-].O=C(c1ccccc1)c1ccccc1O.[Na+].[Na+].c1ccncc1>>CC(C)(C)C(=O)Oc1ccccc1C(=O)c1ccccc1",
        "output": "111"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNCC1.CC1(C)CC(N)CC(C)(C)N1.CCN(C(C)C)C(C)C.CN(C)C=O.ClCCCl.O=C(O)c1cc(-c2ccc(O)cc2)nc2[nH]ncc12.On1nnc2ccccc21>>CC1(C)CC(NC(=O)c2cc(-c3ccc(O)cc3)nc3[nH]ncc23)CC(C)(C)N1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.CCOC(=O)c1c(C)nc2cccc(OC[C@@H]3CCCN3)c2c1N>>CCOC(=O)c1c(C)nc2cccc(OC[C@@H]3CCCN3C(C)=O)c2c1N",
        "output": "369"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CS(=O)(=O)O.O.O=C(O)CCSc1ccc(Br)cc1>>O=C1CCSc2ccc(Br)cc21",
        "output": "274"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cccc2ccoc12.O=C([O-])[O-].[K+].[K+]>>O=C(O)c1cccc2ccoc12",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)C1(C(N)c2ccccc2)CCCC1.CN(C)C1(C(NC(=O)c2cccc(C(F)(F)F)c2Cl)c2ccccc2)CCCC1.Cc1cccc(Br)c1C(=O)O.ClCCl.On1nnc2ccccc21>>Cc1cccc(Br)c1C(=O)NC(c1ccccc1)C1(N(C)C)CCCC1",
        "output": "753"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CC2CNCC1O2.Cl.Nc1ccc(-c2nc(N3CC4CCC(C3)O4)c3cnn(CC(F)(F)F)c3n2)cc1.O=[N+]([O-])c1ccc(-c2nc(N3C4CCCC3COC4)c3cnn(CC(F)(F)F)c3n2)cc1>>Nc1ccc(-c2nc(N3C4CCCC3COC4)c3cnn(CC(F)(F)F)c3n2)cc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.CCCc1c(CC(C)C)csc1C(=O)CCc1cc(C)c(O)c(C)c1.O.OC[C@H](O)CCl.[Na+].[OH-]>>CCCc1c(CC(C)C)csc1C(=O)CCc1cc(C)c(OC[C@@H](O)CO)c(C)c1",
        "output": "74"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](C)(C)OCCCBr.CN(C)C=O.COc1cc([N+](=O)[O-])c(F)cc1O.O=C([O-])[O-].[Cl-].[K+].[K+].[NH4+]>>COc1cc([N+](=O)[O-])c(F)cc1OCCCO[Si](C)(C)C(C)(C)C",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCC.CCO[C@H]1CCN(C(=O)OCc2ccccc2)[C@H](c2ccc(C(=O)O)cc2)C1.CO.C[Si](C)(C)C=[N+]=[N-].Cc1ccccc1>>CCO[C@H]1CCN(C(=O)OCc2ccccc2)[C@H](c2ccc(C(=O)OC)cc2)C1",
        "output": "195"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)C(C)(C)c1ccc(Br)cc1.C[Si](C)(C)[O-].Cl.ClCCl.O.[K+]>>CC(C)(C(=O)O)c1ccc(Br)cc1",
        "output": "203"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1cc(F)c(N2CCC(C(=O)O)CC2)nc1CN1CCCC1=O.NS(=O)(=O)Cc1ccccc1>>CCOC(=O)c1cc(F)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccccc3)CC2)nc1CN1CCCC1=O",
        "output": "644"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.CCN(CC)CC.COc1c(C(C)n2nc(C(F)F)c3c(N)ncnc32)cc(Cl)c(F)c1C1CNC1.Cl.Cl.ClCCl.[Na+]>>COc1c(C(C)n2nc(C(F)F)c3c(N)ncnc32)cc(Cl)c(F)c1C1CN(C(C)C)C1",
        "output": "187"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCO.CN(C(=O)C1CC1)c1ccc(N)cc1.C[Si](C)(C)Cl.Clc1nc(NC2CCC2)c2cc[nH]c2n1>>CN(C(=O)C1CC1)c1ccc(Nc2nc(NC3CCC3)c3cc[nH]c3n2)cc1",
        "output": "592"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2cccnc23)cc1.Cl.Nc1ccc(N2CCOCC2)cc1>>c1cnc2c(c1)nc(Nc1ccc(N3CCOCC3)cc1)c1n[nH]cc12",
        "output": "998"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CCc1ccccc1OCC(=O)OCC.CCO.[H][H].[Pd]>>CCCc1ccccc1OCC(=O)OCC",
        "output": "116"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCOCCOCCOCCOCCO1.Cc1ccccc1.Clc1ccccn1.OCCO.[K+].[OH-]>>OCCOc1ccccn1",
        "output": "433"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CN.COC(=O)C(F)(F)C(F)(F)c1n[nH]c(-c2ccc(N)cc2)n1>>CNC(=O)C(F)(F)C(F)(F)c1n[nH]c(-c2ccc(N)cc2)n1",
        "output": "392"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCOc1nc(Oc2cc(F)ccc2F)nc2oc(-c3cc(C)c(OCC(=O)N4CCC[C@H]4C(=O)OC(C)(C)C)c(C)c3)nc12.ClCCl.O=C(O)C(F)(F)F>>CCCOc1nc(Oc2cc(F)ccc2F)nc2oc(-c3cc(C)c(OCC(=O)N4CCC[C@H]4C(=O)O)c(C)c3)nc12",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1cc(Cl)cc(F)c1-n1c(=O)cc(C(F)(F)F)n(C)c1=O.ClCCl.O=C([O-])O.[Na+]>>Cn1c(C(F)(F)F)cc(=O)n(-c2c(O)cc(Cl)cc2F)c1=O",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)[P+](N(C)C)(N(C)C)n1nnc2ccccc21.F[P-](F)(F)(F)(F)F.NCc1ccc(C=CC2CC2)s1.Nc1ccc(C(=O)O)cn1.O>>Nc1ccc(C(=O)NCc2ccc(C=CC3CC3)s2)cn1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[Si](C)(C)OCCN.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1cc(Br)cc(C)c1-n1c(=O)n(CC(F)(F)F)c2ccccc21.Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>Cc1cc(NCCO[Si](C)(C)C(C)(C)C)cc(C)c1-n1c(=O)n(CC(F)(F)F)c2ccccc21",
        "output": "519"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(C)=O.CNC.N#Cc1cc(Cl)nc(Cl)c1>>CN(C)c1cc(C#N)cc(Cl)n1",
        "output": "220"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)OC(=O)C1CNCC(C)(C)c2cc(C#N)[nH]c21.O=C(Cl)c1ccc(Cl)cc1>>CC(C)OC(=O)C1CN(C(=O)c2ccc(Cl)cc2)CC(C)(C)c2cc(C#N)[nH]c21",
        "output": "201"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)N.CCN(C(C)C)C(C)C.COc1nc(Cl)nc(Cl)c1[N+](=O)[O-].ClCCl>>COc1nc(Cl)nc(NC(C)C)c1[N+](=O)[O-]",
        "output": "110"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)N(O)CC(=O)c1cc(Br)c(N)c(C#N)c1.Cl>>CC(C)(C)N(O)CC(O)c1cc(Br)c(N)c(C#N)c1",
        "output": "24"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=C(O)Cc1coc2cc(NS(=O)(=O)c3ccccc3[N+](=O)[O-])ccc12.O=S(Cl)Cl>>COC(=O)Cc1coc2cc(NS(=O)(=O)c3ccccc3[N+](=O)[O-])ccc12",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCCCCC.CO.COc1cc(N2CCC(N3CCN(S(C)(=O)=O)CC3)CC2)ccc1N.C[O-].Cl.ClCCl.O=C(Nc1c(F)cccc1F)c1cccc(-c2nc3c(F)cccn3c2-c2ccnc(Cl)n2)c1.OCC(F)(F)F.[Na+]>>COc1cc(N2CCC(N3CCN(S(C)(=O)=O)CC3)CC2)ccc1Nc1nccc(-c2c(-c3cccc(C(=O)Nc4c(F)cccc4F)c3)nc3c(F)cccn23)n1",
        "output": "808"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#Cc1cncc(N)c1.CCN(CC)CC.CCOC(C)=O.ClCCl.O.O=C(Cl)C(Cl)Cl>>C#Cc1cncc(NC(=O)C(Cl)Cl)c1",
        "output": "422"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CNc1cc(F)c(C(=O)Nc2ccc(Br)cc2)cc1[N+](=O)[O-].[Ni]>>CNc1cc(F)c(C(=O)Nc2ccc(Br)cc2)cc1N",
        "output": "489"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#CCN(C)C.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.I[Cu]I.Nc1cncc(Br)c1>>CN(C)CC#Cc1cncc(N)c1",
        "output": "719"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COCCNc1nc(OC)c2c(-c3ccccc3)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)oc2n1.ClCCl.O=C(O)C(F)(F)F>>COCCNc1nc(OC)c2c(-c3ccccc3)c(-c3ccc(C4(N)CCC4)cc3)oc2n1",
        "output": "793"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CCCN(c2ccc(Br)cc2)C1.ClCCl.O=C(O)C(F)(F)F.[Na+].[OH-]>>N[C@@H]1CCCN(c2ccc(Br)cc2)C1",
        "output": "538"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CCO[C@@H]1CC[C@@H](N2CCC(N)CC2)CC1.CN(C)C=O.Cc1cc(F)c([N+](=O)[O-])cc1Br.Cl.Cl>>CCO[C@@H]1CC[C@@H](N2CCC(Nc3cc(C)c(Br)cc3[N+](=O)[O-])CC2)CC1",
        "output": "572"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cn1nc(-c2ccc(NC(=O)OC(C)(C)C)cc2)c2cnc(S(C)(=O)=O)nc21.O=C(O)C(F)(F)F>>Cn1nc(-c2ccc(N)cc2)c2cnc(S(C)(=O)=O)nc21",
        "output": "782"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=CCOP(=O)(OCC=C)OCc1c(CO[Si](C)(C)C(C)(C)C)cccc1OC.CCCCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.O.[F-]>>C=CCOP(=O)(OCC=C)OCc1c(CO)cccc1OC",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCCCCc1ccc(OCCNC(=O)OCc2ccccc2)cc1.CCO.ClCCl.[H][H].[Pd]>>CC(C)(C)OC(=O)NCCCCc1ccc(OCCN)cc1",
        "output": "574"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.O=C(O)C(F)(F)F.O=C(O)C[C@H](O)C(=O)O.O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C1C[C@H](O)C(=O)O1>>CC(C)OC(=O)[C@@H](O)CC(=O)O",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.O=S(Cl)Cl.OCc1ccc(-c2ccc(OC(F)(F)F)cc2)nc1>>FC(F)(F)Oc1ccc(-c2ccc(CCl)cn2)cc1",
        "output": "477"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CCCBr.CN(C)C=O.COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1OC.ClCCl.O.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CCOC(=O)CCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)C(OC)C1",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)C(N)c1nccs1.O=C(O)c1cc(OCC2CC2)c(C2CC2)cn1>>CC(C)(C)C(NC(=O)c1cc(OCC2CC2)c(C2CC2)cn1)c1nccs1",
        "output": "137"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.NC(N)=O.Nc1cccc2cc(S(=O)(=O)O)ccc12.O.O=N[O-].O=N[O-].[Na+].[Na+].[OH-]>>O=S(=O)(O)c1ccc2c(Br)cccc2c1",
        "output": "373"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CN(c1cccc(NC(=O)c2cccc(C(C)(C)C#N)c2)c1)c1ncc2nc(NC(=O)CCl)sc2n1.Cl.FC1CCNCC1.O=C([O-])O.[Na+]>>CN(c1cccc(NC(=O)c2cccc(C(C)(C)C#N)c2)c1)c1ncc2nc(NC(=O)CN3CCC(F)CC3)sc2n1",
        "output": "340"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCNc1cccnc1N1CCNCC1.COc1c(C)cc(CCl)cc1C>>CCCNc1cccnc1N1CCN(Cc2cc(C)c(OC)c(C)c2)CC1",
        "output": "156"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(OC)cc(C2CNCCO2)c1.COc1cc2ncnc(Cl)c2cc1OC>>COc1cc(OC)cc(C2CN(c3ncnc4cc(OC)c(OC)cc34)CCO2)c1",
        "output": "296"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)[C@@H]2C[C@H]1[C@H](CCOC1CCCCO1)[C@@H](N)C2.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC1(C)[C@@H]2C[C@H]1[C@H](CCOC1CCCCO1)[C@@H](NS(C)(=O)=O)C2",
        "output": "493"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)Cn1cc(NC(=O)OC(C)(C)C)nn1.[Na+].[OH-]>>CC(C)(C)OC(=O)Nc1cn(CC(=O)O)nn1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CCOC(C)=O.O.O=C([O-])c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1.[Na+]>>O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1",
        "output": "151"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)(C)NS(=O)(=O)c1cncc(-c2c(Cl)nc(Cl)c3c(-c4ccccc4)cccc23)c1.NCc1ccccc1.O=C([O-])O.[Na+]>>CC(C)(C)NS(=O)(=O)c1cncc(-c2c(Cl)nc(NCc3ccccc3)c3c(-c4ccccc4)cccc23)c1",
        "output": "612"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.ClCCl.O=S(=O)(O)Cl.c1ccc(OCCN2CCOCC2)cc1.c1ccc(OCCN2CCOCC2)cc1>>O=S(=O)(Cl)c1ccc(OCCN2CCOCC2)cc1",
        "output": "357"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Nc1csc2c(CSc3nc4ccccc4[nH]3)nccc12.CO.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.O=S([O-])[O-].[Na+].[Na+].[Na+]>>CC(=O)Nc1csc2c(CS(=O)c3nc4ccccc4[nH]3)nccc12",
        "output": "595"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc(F)ccc1N1CCNCC1.Cc1ccc2c(c1)NC(C(=O)O)CC2.O=C(C1CCc2ccccc2N1)N1CCN(c2cccc3[nH]ccc23)CC1.O=C(O)C1CCc2ccccc2N1>>COc1cc(F)ccc1N1CCN(C(=O)C2CCc3ccc(C)cc3N2)CC1",
        "output": "685"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.Cl.ClCCN1CCOCC1.O=C([O-])[O-].O=[N+]([O-])c1cccc(O)c1.[K+].[K+]>>O=[N+]([O-])c1cccc(OCCN2CCOCC2)c1",
        "output": "74"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(=O)N[Si](C)(C)C.CC(C)OC(C)C.CON=C(C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[N+]3(C)CCNCC3)CS[C@H]12)c1nsc(N)n1.CS(C)=O.O=C(O)c1cc(O)c(O)cn1.On1nnc2ccccc21>>CON=C(C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[N+]3(C)CCN(C(=O)c4cc(O)c(O)cn4)CC3)CS[C@H]12)c1nsc(N)n1",
        "output": "605"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)[C@H](NC(=O)c1ccccc1OCc1ccccc1)[C@H](C)O.O.[Na+].[OH-]>>C[C@H](O)[C@@H](NC(=O)c1ccccc1OCc1ccccc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)c1cc(C#N)c(N2CC(CN)C2)nc1C.CO.Cl.Cl.ClCCl.O=C(Cl)Cc1ccccc1>>CCOC(=O)c1cc(C#N)c(N2CC(CNC(=O)Cc3ccccc3)C2)nc1C",
        "output": "45"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.ClCCl.N[C@H]1CCC[C@@H]1O.O=S(=O)(Cl)c1ccc(Br)cc1>>O=S(=O)(N[C@H]1CCC[C@@H]1O)c1ccc(Br)cc1",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.Nc1cccc(F)c1Br.O.O=C(Cl)C=Cc1ccccc1.O=C([O-])[O-].[K+].[K+]>>O=C(C=Cc1ccccc1)Nc1cccc(F)c1Br",
        "output": "10"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CC(=O)[O-].O=c1[nH]c(-c2cccc(O)c2)nc2ccsc12.[Na+]>>CC(=O)Oc1cccc(-c2nc3ccsc3c(=O)[nH]2)c1",
        "output": "46"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.COC1(C(=O)N2CC[C@](c3ccc(C(F)(C(F)(F)F)C(F)(F)F)cc3)(S(=O)(=O)c3ccc(F)cc3)C2)CCC(CO)CC1.ClCCl>>COC1(C(=O)N2CC[C@](c3ccc(C(F)(C(F)(F)F)C(F)(F)F)cc3)(S(=O)(=O)c3ccc(F)cc3)C2)CCC(C=O)CC1",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCO.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.ClCCl.Cn1cc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1C(=O)O.F[B-](F)(F)F.NCc1ccc(C2CCC3(CC2)OCCO3)cc1>>Cn1cc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1C(=O)NCc1ccc(C2CCC3(CC2)OCCO3)cc1",
        "output": "905"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(-c3ccccc3)cn(C)c2c1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li+].[OH-]>>Cn1cc(-c2ccccc2)c2ccc(C(=O)O)cc21",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)CCNC(=O)c1cccc(NCc2ccc(C=NN)cc2)c1.CO.[Li+].[OH-]>>NN=Cc1ccc(CNc2cccc(C(=O)NCCC(=O)O)c2)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cccc2c(Cl)nc(Nc3cc(C)[nH]n3)cc12.OB(O)c1ccccc1F>>COc1cccc2c(-c3ccccc3F)nc(Nc3cc(C)[nH]n3)cc12",
        "output": "865"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1CCCN1CCCOc1ccc(N2CC(CO)CC2=O)cc1.CCN(CC)CC.ClCCl.O=S(Cl)Cl>>CC1CCCN1CCCOc1ccc(N2CC(CCl)CC2=O)cc1",
        "output": "96"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)c1ccc2cccccc1-2.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Mg+2].[Na+].[OH-]>>CC(O)c1ccc2cccccc1-2",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F)C1=CCN(Cc2ccccc2)CC1.CC1(C)OC[C@H](CCN)O1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)C(F)(F)F>>CC1(C)OC[C@H](CCNC(=O)C2NC(CC(C)(C)C3=CCN(Cc4ccccc4)CC3)C(C#N)(c3ccc(Cl)cc3F)C2c2cccc(Cl)c2F)O1",
        "output": "216"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(N)=NO.CN(C)C=O.CS(=O)(=O)c1ccc(CC(=O)O)cc1.O=C(n1ccnc1)n1ccnc1>>Cc1noc(Cc2ccc(S(C)(=O)=O)cc2)n1",
        "output": "728"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.Nc1cccnc1.O.O=C(Cl)c1cccc([N+](=O)[O-])c1>>O=C(Nc1cccnc1)c1cccc([N+](=O)[O-])c1",
        "output": "501"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCCCCCC.CCOC(C)=O.COC(=O)c1ccc(C2=NOC(c3cc(Cl)c(F)c(Cl)c3)(C(F)(F)F)C2)c2ccccc12.O.[Li]>>O=C(O)c1ccc(C2=NOC(c3cc(Cl)c(F)c(Cl)c3)(C(F)(F)F)C2)c2ccccc12",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COCCOc1ccc(C=O)cc1Br.N#Cc1cnc2ccc(N)cc2c1Nc1ccc(F)c(Cl)c1.[BH3-]C#N.[Na+]>>COCCOc1ccc(CNc2ccc3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)cc1Br",
        "output": "359"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)OCCn1nnc(-c2cccc(-c3ccnc4c(C(=O)c5cccs5)cnn34)c2)n1.OCCBr>>O=C(c1cccs1)c1cnn2c(-c3cccc(-c4nnn(CCO)n4)c3)ccnc12",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCO.Clc1cc(Cl)nc(-c2ccccc2)n1.O.OC1CCNCC1>>OC1CCN(c2cc(Cl)nc(-c3ccccc3)n2)CC1",
        "output": "162"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.C[O-].NC1(c2ccc(-c3nc4c(-c5cc[nH]n5)cc(Cl)nn4c3-c3ccccc3)cc2)CCC1.O.[Na+]>>COc1cc(-c2cc[nH]n2)c2nc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)n2n1",
        "output": "407"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc2c(=O)n(CC(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)NCc3cccnc3)c(C#N)c(-c3ccccc3)c2c1.[F-]>>COc1ccc2c(=O)n(CC(CO)NCc3cccnc3)c(C#N)c(-c3ccccc3)c2c1",
        "output": "781"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.C[C@@H](C1CCCCC1)N1CC[C@](CCCOS(C)(=O)=O)(c2ccc(F)cc2)OC1=O.[N-]=[N+]=[N-].[Na+]>>C[C@@H](C1CCCCC1)N1CC[C@](CCCN=[N+]=[N-])(c2ccc(F)cc2)OC1=O",
        "output": "322"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O[C@@H]1CC[C@@H](c2ccc(Br)cc2)CC1>>CC1(C)OB(c2ccc([C@@H]3CC[C@@H](O)CC3)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.CC(O)C1=CS[C@@H]2C(NC(=O)Cc3cccs3)C(=O)N2C1C(=O)OC(c1ccccc1)c1ccccc1.ClCCl.c1ccncc1>>CC(=O)OC(C)C1=CS[C@@H]2C(NC(=O)Cc3cccs3)C(=O)N2C1C(=O)OC(c1ccccc1)c1ccccc1",
        "output": "155"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(O)(CF)CF)CC2)c2ncnn12.CCOC(C)=O.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n([C@@H]2CC[C@@H](OCC(O)(CF)CF)CC2)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(O)c1cccc2c1CCCc1ccccc1-2.O=S(Cl)Cl>>O=C(Cl)c1cccc2c1CCCc1ccccc1-2",
        "output": "3"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC=O.COc1ccc2[nH]cc(CCCNC3COc4c(F)ccc(C(N)=O)c4C3)c2c1>>CCCN(CCCc1c[nH]c2ccc(OC)cc12)C1COc2c(F)ccc(C(N)=O)c2C1",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCCCCCCCn1c(C)c(-c2ccc(Cl)cc2)c2cc(O)ccc21.CCOC(=O)C(C)(C)Br>>CCCCCCCCCCCCn1c(C)c(-c2ccc(Cl)cc2)c2cc(OC(C)(C)C(=O)OCC)ccc21",
        "output": "305"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCCCCCCOc1cnc(-c2ccc(O)cc2)nc1.CCOC(=O)N=NC(=O)OCC.C[Si](C)(C)CCCCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCCCCCCOc1cnc(-c2ccc(OCCCC[Si](C)(C)C)cc2)nc1",
        "output": "550"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CCO.NC(N)=S.O=C(O)c1ccc(C(=O)CBr)cc1.[Na+]>>Nc1nc(-c2ccc(C(=O)O)cc2)cs1",
        "output": "716"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)O.CN1C(=O)C(F)(F)CN(C2CCCCC2)c2nc(Cl)ncc21.COc1cc(C(=O)NC2CCN(CCO)CC2)ccc1N.Cc1ccccc1S(=O)(=O)O.O>>COc1cc(C(=O)NC2CCN(CCO)CC2)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CC(F)(F)C(=O)N2C",
        "output": "941"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)c1cc2c(cc1CC(=O)O)OCO2.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC(C)c1cc2c(cc1CCO)OCO2",
        "output": "231"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)NC(CCc1ccc(-c2ccc(O)cc2F)cc1)(COC(C)=O)COC(C)=O.CC(=O)[O-].CC(=O)[O-].Cc1ccc(B(O)O)cc1.ClCCl.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Cu+2].c1ccncc1>>CC(=O)NC(CCc1ccc(-c2ccc(Oc3ccc(C)cc3)cc2F)cc1)(COC(C)=O)COC(C)=O",
        "output": "920"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)COc1ccc2cc(CNC(=O)c3cc(-c4ccc(Cl)cc4)oc3C)ccc2c1.Cl.O.[Na+].[OH-]>>Cc1oc(-c2ccc(Cl)cc2)cc1C(=O)NCc1ccc2cc(OCC(=O)O)ccc2c1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CN(N)c1ccccc1.Cl.O=Cc1cccc2ccccc12>>CN(N=Cc1cccc2ccccc12)c1ccccc1",
        "output": "167"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(C)[C@@H](Cn1ccnc1)Oc1ccc2c(c1[N+](=O)[O-])CCCC2=O.CCOC(C)=O.CO.O.O=C([O-])O.[Fe].[Na+]>>CC(C)[C@@H](Cn1ccnc1)Oc1ccc2c(c1N)CCCC2=O",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=Cc1ccc(C=O)cc1.[BH4-].[Na+]>>O=Cc1ccc(CO)cc1",
        "output": "356"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Cl.ClCCN1CCCC1.O=C([O-])[O-].O=[N+]([O-])c1cccc2[nH]ncc12.[K+].[K+]>>O=[N+]([O-])c1cccc2c1cnn2CCN1CCCC1",
        "output": "604"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C(OC(C)(C)C)OC(C)(C)C.C[C@@H](Oc1ccc(C#N)c(F)c1)C(=O)O.Cc1ccccc1>>C[C@@H](Oc1ccc(C#N)c(F)c1)C(=O)OC(C)(C)C",
        "output": "768"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CNCCN1.Cc1ccc(C(C)C)c(Br)c1>>Cc1ccc(C(C)C)c(N2CCNCC2)c1",
        "output": "294"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Cl.Nc1ccc2ncc(=O)[nH]c2c1>>COc1ccc2nc(Nc3ccc4ncc(=O)[nH]c4c3)c3n[nH]cc3c2c1",
        "output": "998"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOP(=O)(Cn1c(=O)c(=O)[nH]c2cc([N+](=O)[O-])c3ccccc3c21)OCC.CN(C)C=O.O.O=[Pt].[H][H]>>CCOP(=O)(Cn1c(=O)c(=O)[nH]c2cc(N)c3ccccc3c21)OCC",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C[Si](C)(C)CCOCn1cc(-c2nccc3[nH]c(=O)c(-c4ccccc4F)cc23)cn1.O=P(Cl)(Cl)Cl>>C[Si](C)(C)CCOCn1cc(-c2nccc3nc(Cl)c(-c4ccccc4F)cc23)cn1",
        "output": "100"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CO.CS(C)=O.C[C@H](N)c1nc2cc(Cl)ccc2[nH]1.ClCCl.ClCl.F[B-](F)(F)F.O=C(O)c1ccc(-n2cnc3c(=O)[nH]ccc32)c(C(F)(F)F)c1>>C[C@H](NC(=O)c1ccc(-n2cnc3c(=O)[nH]ccc32)c(C(F)(F)F)c1)c1nc2cc(Cl)ccc2[nH]1",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CN.COCCOc1nc(Cl)c([N+](=O)[O-])cc1C(=O)N[C@@H]1CC[C@@H](C(F)(F)F)CC1.O>>CNc1nc(OCCOC)c(C(=O)N[C@@H]2CC[C@@H](C(F)(F)F)CC2)cc1[N+](=O)[O-]",
        "output": "70"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "FC(F)(F)c1cccc(N2CCCNCC2)c1.O=C1CCC(c2c[nH]c3cc(F)ccc23)CC1>>Fc1ccc2c(C3CCC(N4CCCN(c5cccc(C(F)(F)F)c5)CC4)CC3)c[nH]c2c1",
        "output": "187"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNCC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.O=Cc1cncc(Br)c1.[Na+]>>Brc1cncc(CN2CCCCC2)c1",
        "output": "757"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=[N+]=[N-].CCOCC.CO.C[C@H]1[C@H](C)CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@]43C)[C@H]12>>COC(=O)[C@]12CC[C@@H](C)[C@H](C)[C@H]1C1=CC[C@@H]3[C@@]4(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]4CC[C@@]3(C)[C@]1(C)CC2",
        "output": "195"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.C[O-].O=[N+]([O-])c1ccc(Cl)cc1CBr.[Na+]>>COCc1cc(Cl)ccc1[N+](=O)[O-]",
        "output": "464"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCc1ncnc(-c2ccc(C(=O)OC)c(Cl)c2)c1C#Cc1ccc(N)nc1.O.[Li+].[OH-]>>CCc1ncnc(-c2ccc(C(=O)O)c(Cl)c2)c1C#Cc1ccc(N)nc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cccc(-c2nc(N3CCOCC3)nc(Cl)c2CCCl)c1.COc1cccc(-c2nc(N3CCOCC3)nc3c2CCN3c2cc(C)nc3ccccc23)c1.Cc1cc(N)c2ccccc2n1>>Cc1cc(N2CCc3c(-c4cccc(O)c4)nc(N4CCOCC4)nc32)c2ccccc2n1",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCCCCCc1noc(-c2cccc(C=O)c2)n1.NCc1cccc(C(F)(F)F)c1>>CCCCCCCCCCCc1noc(-c2cccc(CNCc3cccc(C(F)(F)F)c3)c2)n1",
        "output": "683"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)[O-].CC(=O)[O-].CC1(C)CCC=C1B1OC(C)(C)C(C)(C)O1.CCOC(=O)c1ccc(-c2cc(OC)ccc2F)c(C2=CCCC2(C)C)c1.CCOC(=O)c1ccc(-c2cc(OC)ccc2F)c(Cl)c1.CCOCC.CN(C)C=O.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.O.O=P([O-])([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[K+].[K+].[K+].[Li+].[Na+].[OH-].[Pd+2]>>COc1ccc(F)c(-c2ccc(CO)cc2C2=CCCC2(C)C)c1",
        "output": "311"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.Cc1ccc(O)cc1.Cc1nccn1-c1nc(-c2ccc(Cl)cc2)c(CCCO)o1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>Cc1ccc(OCCCc2oc(-n3ccnc3C)nc2-c2ccc(Cl)cc2)cc1",
        "output": "478"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.COC(=O)[C@H]1C[C@H](N)[C@H](c2ccccc2)N(C(=O)OCc2ccccc2)C1.COc1ccc(OC(F)(F)F)cc1C=O.ClCCl.O=C([O-])[O-].[Na+].[Na+].[Na+]>>COC(=O)[C@H]1C[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)N(C(=O)OCc2ccccc2)C1",
        "output": "468"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCO.CCOC(=O)CCCC(=O)N1CCC2(CC1)CC(c1ccc(C=NN)cc1)=NO2.Cl.[Na+].[OH-]>>NN=Cc1ccc(C2=NOC3(CCN(C(=O)CCCC(=O)O)CC3)C2)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)c1ncc(OCC(F)(F)F)cc1Cl.CC[N+](CC)(CC)c1ccccc1.CC[N+](CC)(CC)c1ccccc1.CC[N+](CC)(CC)c1ccccc1.[Br-].[Br-].[Br-]>>O=C(CBr)c1ncc(OCC(F)(F)F)cc1Cl",
        "output": "360"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1ccc(-c2ccc(N(C(N)=O)c3cccc(C(F)(F)F)c3)c(-c3nnn[nH]3)c2)cc1.Cl.[Na+].[OH-]>>NC(=O)N(c1cccc(C(F)(F)F)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1-c1nnn[nH]1",
        "output": "5"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(Cl)nnc1NS(=O)(=O)Cc1cc(C#N)ccc1Cl.COc1cc(Cl)nnc1NS(=O)(=O)c1cc(Cl)sc1Cl.N#Cc1ccc(Cl)c(CS(=O)(=O)Nc2nnc(Cl)cc2O)c1>>O=S(=O)(Nc1nnc(Cl)cc1O)c1cc(Cl)sc1Cl",
        "output": "424"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CN1CCCN(Cc2ccc(-c3cccc(-n4c(=O)n([C@H]5CC[C@@H](NC(=O)OC(C)(C)C)CC5)c(=O)c5cc(F)cnc54)c3)cc2)CC1.Cl>>CN1CCCN(Cc2ccc(-c3cccc(-n4c(=O)n([C@H]5CC[C@@H](N)CC5)c(=O)c5cc(F)cnc54)c3)cc2)CC1",
        "output": "538"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrP(Br)Br.COc1cc(-c2cccc(NC(=O)c3ccc(C(C)(C)C)cc3)c2C)ccn1.ClCCCl.O=C([O-])O.[Na+]>>Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1cc[nH]c(=O)c1",
        "output": "758"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.CCn1nnnc1-c1cc(C(=O)O)cc(-c2ccc(C)cc2)c1.CN1CCCC1=O.COCC(C)N.ClCCl.On1nnc2ccccc21>>CCn1nnnc1-c1cc(C(=O)NC(C)COC)cc(-c2ccc(C)cc2)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "NC1C(=O)N2C(C(=O)O)=C(CSc3nncs3)CS[C@H]12.O=CNc1nc(C(=NOCCCl)C(=O)O)cs1>>O=CNc1nc(C(=NOCCCl)C(=O)NC2C(=O)N3C(C(=O)O)=C(CSc4nncs4)CS[C@H]23)cs1",
        "output": "587"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Cl.O=[N+]([O-])c1cccc(S(=O)(=O)N2CC=CC2)c1.[In]>>Nc1cccc(S(=O)(=O)N2CC=CC2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCCCBr.CC(C)=O.O=C([O-])[O-].O=[N+]([O-])c1cccc(O)c1.[I-].[K+].[K+].[K+]>>O=[N+]([O-])c1cccc(OCCCBr)c1",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OCC(=O)c1cnc(C)nc1C1CCNCC1(F)F.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O.O=C(O)Cc1c(F)cccc1F>>CC(=O)OCC(=O)c1cnc(C)nc1C1CCN(C(=O)Cc2c(F)cccc2F)CC1(F)F",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCNC2.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C(O)C(F)(F)F>>CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)CCN(S(C)(=O)=O)C2",
        "output": "584"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)CCCCCCCCN1NNN=C1C(c1ccccc1)c1ccccc1.[Na+].[OH-]>>O=C(O)CCCCCCCCN1NNN=C1C(c1ccccc1)c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrC(Br)(Br)Br.C=CC[Si](CC=C)(CC=C)CCCc1ccc(CO)cc1.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C=CC[Si](CC=C)(CC=C)CCCc1ccc(CBr)cc1",
        "output": "750"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1ccc(CCOCc2ccccc2)cc1.C1CCOC1.CN(C)C=O.[Cl-].[Li]CCCC.[NH4+]>>O=Cc1ccc(CCOCc2ccccc2)cc1",
        "output": "638"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCCCOc1cccc2ccccc12.Cl.O=C(NC1CCNCC1)c1ccccc1.O=C([O-])[O-].[K+].[K+]>>O=C(NC1CCN(CCCOc2cccc3ccccc23)CC1)c1ccccc1",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.O=C(Cl)CCCCl.[Al+3].[Cl-].[Cl-].[Cl-].c1ccccc1>>O=C(CCCCl)c1ccccc1",
        "output": "31"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC1=C(N2CCC3(CCN(C(=O)OC(C)(C)C)CC3)C2=O)COC1=O.ClCCl.O=C(O)C(F)(F)F>>CCC1=C(N2CCC3(CCNCC3)C2=O)COC1=O",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CSc1ccccc1Oc1ccccc1N.Nc1ccccc1OCc1ccccc1.O=C(O)c1ccncc1F>>O=C(Nc1ccccc1OCc1ccccc1)c1ccncc1F",
        "output": "50"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(C=O)ccc21.ClCCl.NCCOCCO.[Na+]>>CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CNCCOCCO)ccc21",
        "output": "468"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(N)cc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CS(C)=O.F[P-](F)(F)(F)(F)F.O.O=C(O)[C@@H]1CCCN1C(=O)OCc1ccccc1>>CC(C)(C)OC(=O)Nc1ccc(NC(=O)[C@@H]2CCCN2C(=O)OCc2ccccc2)cc1",
        "output": "563"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCC(CC#C)(C(=O)O)S(=O)(=O)c1ccc(OC)cc1.Cl.NO.[Br-].[K+]>>C#CCC(CC#C)(C(=O)NO)S(=O)(=O)c1ccc(OC)cc1",
        "output": "480"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)CC(c1cc(OCc2ccc(-c3cc(OC)ccc3F)c(CC(C)(C)C)n2)ncn1)C1CC1.CO.Cl.[Na+].[OH-]>>COc1ccc(F)c(-c2ccc(COc3cc(C(CC(=O)O)C4CC4)ncn3)nc2CC(C)(C)C)c1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(Br)CC.CCOc1cc(C=O)ccc1O.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOc1cc(C=O)ccc1OC(CC)CC",
        "output": "153"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCc1nc2c(Cl)ccc(OCC(=O)OC)c2c(OC(F)F)c1Cc1ccc(C(=O)C(C)(C)C)cc1.[Li+].[OH-]>>CCc1nc2c(Cl)ccc(OCC(=O)O)c2c(OC(F)F)c1Cc1ccc(C(=O)C(C)(C)C)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COC(=O)c1ccc(-c2n[nH]c3cccc(F)c23)c(F)c1.Fc1ccc(F)c(CCl)c1.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)c1ccc(-c2nn(Cc3cc(F)ccc3F)c3cccc(F)c23)c(F)c1",
        "output": "842"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(C)=O.CO.Cc1ncc(-c2cc(Oc3ccc([N+](=O)[O-])nc3)ccn2)o1.[Cl-].[NH4+].[Zn]>>Cc1ncc(-c2cc(Oc3ccc(N)nc3)ccn2)o1",
        "output": "457"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN1CCC(CN)(c2ccc(Cl)c(Cl)c2)CC1.CCOCC.COc1c(C#N)cc2ccccc2c1C(=O)Cl>>CCN1CCC(CNC(=O)c2c(OC)c(C#N)cc3ccccc23)(c2ccc(Cl)c(Cl)c2)CC1",
        "output": "271"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "B.C1CCOC1.CC(=O)N(Cc1ccc(Cl)c(Oc2ccccc2)c1F)C1CCC(N)CC1>>CCN(Cc1ccc(Cl)c(Oc2ccccc2)c1F)C1CCC(N)CC1",
        "output": "533"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.Cc1cnc(NCC2CCN(C(=O)OC(C)(C)C)CC2)nc1C(C#N)=C1Nc2ccccc2O1.ClCCl.O=C(O)C(F)(F)F>>Cc1cnc(NCC2CCNCC2)nc1C(C#N)=C1Nc2ccccc2O1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cl.COc1ccc2cc(OCC3(C(=O)O)CN(C(=O)c4ccc(F)cc4)C3)ccc2c1.ClCCl.N>>COc1ccc2cc(OCC3(C(N)=O)CN(C(=O)c4ccc(F)cc4)C3)ccc2c1",
        "output": "313"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.COCCCc1cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@]2(O)c2ccc(=O)n(C)c2)C2CC2)cc(OCCOC)c1.[H-].[Na+]>>COCCCc1cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@]2(OC)c2ccc(=O)n(C)c2)C2CC2)cc(OCCOC)c1",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.N#Cc1c2cc(Br)c([N+](=O)[O-])cc2nn1-c1ccc(F)cc1.O.[Cl-].[Fe].[NH4+]>>N#Cc1c2cc(Br)c(N)cc2nn1-c1ccc(F)cc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cn1c(Nc2nc3ccc(Cl)cc3s2)nc2cc(C(=O)NCC(=O)O)ccc21.F[P-](F)(F)(F)(F)F.OC1CCNC1>>Cn1c(Nc2nc3ccc(Cl)cc3s2)nc2cc(C(=O)NCC(=O)N3CCC(O)C3)ccc21",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.Cl[Sn]Cl.N#Cc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1.[Na+].[OH-]>>N#Cc1cc(N)cc(N)c1",
        "output": "204"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.ClC(Cl)Cl.ClC(Cl)Cl.NCCN.O=S(=O)(Cl)c1cccc2cnccc12>>NCCNS(=O)(=O)c1cccc2cnccc12",
        "output": "43"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1ccc(F)c([N+](=O)[O-])c1.O=C(Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C(Cl)c1cccs1>>O=C(Nc1ccc(F)c([N+](=O)[O-])c1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "11"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CO.COC(=O)c1ccc(Cl)nc1.ClCCl.NC(N)=O.O=C(OC(=O)C(F)(F)F)C(F)(F)F.OO>>COC(=O)c1ccc(Cl)[n+]([O-])c1",
        "output": "396"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CCOCCCCCCCCCCO.CCOCC.O=C(Cl)C1CC1.c1ccncc1>>C#CCOCCCCCCCCCCOC(=O)C1CC1",
        "output": "126"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1c(N[C@@H](c2nnc(-c3ccc(C#N)cc3)o2)[C@H](C)O)ccc(C#N)c1Cl.ClCCl.O=C(Cl)c1ccccc1.c1ccncc1>>Cc1c(N[C@@H](c2nnc(-c3ccc(C#N)cc3)o2)[C@H](C)OC(=O)c2ccccc2)ccc(C#N)c1Cl",
        "output": "51"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCC(O)c1ccccc1-c1ccc2[nH]c(COc3ccc(C(F)(F)F)cc3)nc2c1.ClCCl>>CCC(=O)c1ccccc1-c1ccc2[nH]c(COc3ccc(C(F)(F)F)cc3)nc2c1",
        "output": "32"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCI.CN(C)C=O.O=C(c1ccc(-c2cc[nH]n2)cc1)N1Cc2cccn2Cc2ccccc21.[H-].[Na+]>>CCn1ccc(-c2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)cc2)n1",
        "output": "346"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1ccc2c(c1)[nH]c1ccccc12.O=Cc1ccccc1>>O=C(C=Cc1ccccc1)c1ccc2c(c1)[nH]c1ccccc12",
        "output": "295"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COc1ccc2nccc(C(O)CC[C@@H]3CCNC[C@@H]3C(=O)O)c2c1.O=C1CC(O)(c2ccccc2)C1.[BH3-]C#N>>COc1ccc2nccc(C(O)CC[C@@H]3CCN(C4CC(O)(c5ccccc5)C4)C[C@@H]3C(=O)O)c2c1",
        "output": "187"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCCC(C(=O)NCCNc2nsc3ccccc23)C1.ClCCl.O=C(O)C(F)(F)F>>O=C(NCCNc1nsc2ccccc12)C1CCCNC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)O[C@@H]1C[C@@H](CN)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1.O.O=C(Cl)CCl.[Cl-].[Na+].[Na+].[OH-]>>CC(C)(C)[Si](C)(C)O[C@@H]1C[C@@H](CNC(=O)CCl)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1",
        "output": "45"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COC(=O)c1c(Br)c2ccc(O[Si](C)(C)C(C)(C)C)cc2n1C(=O)OC(C)(C)C.[Cs+].[F-]>>COC(=O)c1c(Br)c2ccc(O)cc2n1C(=O)OC(C)(C)C",
        "output": "754"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1ccc2cc(Br)ccc2c1.Cc1ccccc1.O=C([O-])[O-].OB(O)c1ccccc1-c1ccccc1.[Na+].[Na+]>>Brc1ccc2cc(-c3ccccc3-c3ccccc3)ccc2c1",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)OCC(COC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)OC(=O)CCC(=O)O.CN(C)C=O.CN(C)c1ccncc1.Nc1nc2c(ncn2[C@H]2C[C@H](F)[C@@H](CO)O2)c(=O)[nH]1.On1nnc2ccccc21>>CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)OCC(COC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)OC(=O)CCC(=O)OC[C@H]1O[C@@H](n2cnc3c(=O)[nH]c(N)nc32)C[C@@H]1F",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)O.O=C(CBr)Nc1cccc(-c2cnc3ccccc3n2)c1.OC1CCNCC1>>O=C(CN1CCC(O)CC1)Nc1cccc(-c2cnc3ccccc3n2)c1",
        "output": "443"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)NC[C@H]1CN(c2ccc(C34CNCC3C4)cc2)C(=O)O1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CCN(CC)CC.O=Cc1cccnc1.[Na+]>>CC(=O)NC[C@H]1CN(c2ccc(C34CC3CN(Cc3cccnc3)C4)cc2)C(=O)O1",
        "output": "757"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)cc3c2C(=O)NC3)c1.ClCCl.O=C1CCC(=O)N1I>>Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)c(I)c3c2C(=O)NC3)c1",
        "output": "783"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.Cl.ClCCl.O=C(NCC1CN(Cc2ccc(Cl)c(Cl)c2)CCO1)NC1CCNCC1>>CS(=O)(=O)N1CCC(NC(=O)NCC2CN(Cc3ccc(Cl)c(Cl)c3)CCO2)CC1",
        "output": "584"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN1CCc2nc(Nc3cc(Br)cn(C)c3=O)sc2C1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[K+].[Pd].[Pd]>>CN1CCc2nc(Nc3cc(B4OC(C)(C)C(C)(C)O4)cn(C)c3=O)sc2C1",
        "output": "943"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.N[C@H]1CC[C@H](O)CC1.O.O=C(Cl)OCc1ccccc1.[Na+].[OH-]>>O=C(N[C@@H]1CC[C@@H](O)CC1)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COc1cccc(CNC(=O)OC(C)(C)C)c1.Cl>>COc1cccc(CN)c1",
        "output": "793"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)Cc1ccc(N)cc1.Clc1cc(SC2CCCC2)nc2c1CCC2>>CCOC(=O)Cc1ccc(Nc2cc(SC3CCCC3)nc3c2CCC3)cc1",
        "output": "115"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "B1C2CCCC1CCC2.C1CCOC1.C=CCC(c1ccc(C#N)c(F)c1)n1ccnc1C.O=C([O-])O.OO.[Na+]>>Cc1nccn1C(CCCO)c1ccc(C#N)c(F)c1",
        "output": "465"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCC(O)c1ccccc1.CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCCC(OC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(C)c1C)c1ccccc1",
        "output": "960"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCOC(C)=O.NC1CCCCC1.NS(=O)(=O)c1ccc(Cl)c([N+](=O)[O-])c1>>NS(=O)(=O)c1ccc(NC2CCCCC2)c([N+](=O)[O-])c1",
        "output": "304"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C(CC)c1ccc(Cl)cc1.NN.O>>CCC(C(=O)NN)c1ccc(Cl)cc1",
        "output": "164"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CC1(c2ccc(OCc3cccc(-c4ccc(OCCCS(C)(=O)=O)cc4Cl)c3)cc2)COC1.CO.O.[Li+].[OH-]>>CS(=O)(=O)CCCOc1ccc(-c2cccc(COc3ccc(C4(CC(=O)O)COC4)cc3)c2)c(Cl)c1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CN1C(=O)C2(CC2)c2cc(NC(=O)C(F)(F)F)ccc21.O.O=[N+]([O-])O>>CN1C(=O)C2(CC2)c2cc(NC(=O)C(F)(F)F)c([N+](=O)[O-])cc21",
        "output": "21"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCO.CCS(=O)(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2[N+](=O)[O-])c1C>>CCS(=O)(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2N)c1C",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCS(=O)(=O)Cl.N#Cc1cccc2c1OCC(c1cncc(CN)c1)O2.O=C(O)C(F)(F)F>>CCS(=O)(=O)NCc1cncc(C2COc3c(C#N)cccc3O2)c1",
        "output": "493"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)CCn1ccnc1CCC(=O)O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)[C@H]1CCCNC1.ClCCl.F[P-](F)(F)(F)(F)F>>CCOC(=O)CCn1ccnc1CCC(=O)N1CCC[C@H](N(C)C)C1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.Cl.ClCCl.Fc1ccc(N2N=C(C(F)(F)C(F)(F)F)CC2c2cc(N3CCNCC3)ccn2)c(F)c1.O=S(=O)(Cl)C1CC1>>O=S(=O)(C1CC1)N1CCN(c2ccnc(C3CC(C(F)(F)C(F)(F)F)=NN3c3ccc(F)cc3F)c2)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(N)CO.O=C(O)c1cc(-c2cccc(Cl)c2)c(Cl)cn1>>CC(C)(CO)NC(=O)c1cc(-c2cccc(Cl)c2)c(Cl)cn1",
        "output": "137"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.COC(=O)Cl.Cc1cccc2ncc(C(=O)O)c(=O)n12.ClC(Cl)Cl.NC1CCCCCC1>>Cc1cccc2ncc(C(=O)NC3CCCCCC3)c(=O)n12",
        "output": "737"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N(Cc1ccc2c(c1)OCCO2)C1CCNCC1.CCOC(C)=O.ClCCl.O.O=C([O-])O.O=CCn1c(=O)ccc2ccccc21.[Na+].[Na+]>>CC(C)(C)OC(=O)N(Cc1ccc2c(c1)OCCO2)C1CCN(CCn2c(=O)ccc3ccccc32)CC1",
        "output": "484"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COCCO.Clc1ncc(Br)cn1.[H-].[Na+]>>COCCOc1ncc(Br)cn1",
        "output": "37"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C(=O)N[C@H]1C[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O.CCn1cnc(CCN)c1>>CCn1cnc(CCNc2nc(N)c3ncn([C@@H]4C[C@H](NC(=O)C(C)C)[C@@H](O)[C@H]4O)c3n2)c1",
        "output": "578"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Fc1ccc(C(c2ccc(F)cc2)C2CCNCC2)cc1.Fc1ccc(OCCCCl)cc1>>Fc1ccc(OCCCN2CCC(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1",
        "output": "138"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)O.CO.COc1ccc(Oc2cc(Cl)ccc2[N+](=O)[O-])cc1.[Zn]>>COc1ccc(Oc2cc(Cl)ccc2N)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.CC(C)(C)OC(=O)Nc1cc(Cl)c(F)cc1[N+](=O)[O-].CS(C)=O>>CC(C)(C)OC(=O)Nc1cc(N2CCCC2)c(F)cc1[N+](=O)[O-]",
        "output": "105"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=O.CO.Cc1cc(C)c(CNC(=O)c2cc(C3=CCN(C(=O)C4CCNCC4)CC3)nc3c2cnn3C(C)C)c(=O)[nH]1.[BH3-]C#N.[Na+]>>Cc1cc(C)c(CNC(=O)c2cc(C3=CCN(C(=O)C4CCN(C)CC4)CC3)nc3c2cnn3C(C)C)c(=O)[nH]1",
        "output": "217"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClC(Cl)Cl.Cn1cccc1C(=O)NCCO.O=S(Cl)Cl.c1ccncc1>>Cn1cccc1C(=O)NCCCl",
        "output": "96"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1cncc(N2CC3CC4CC2CN(C4)C3)c1.OB(O)c1cccnc1>>c1cncc(-c2cncc(N3CC4CC5CC3CN(C5)C4)c2)c1",
        "output": "883"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)Cn1ncc2cc(Oc3ccc(F)cc3CNC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)ccc21.[BH4-].[Na+]>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)ccc2Oc2ccc3c(cnn3CCO)c2)cc1",
        "output": "343"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#CCOc1ccc(CCC(=O)Cl)cc1OC.COC(=O)c1ccc(CN)cc1.Cl>>C#CCOc1ccc(CCC(=O)NCc2ccc(C(=O)OC)cc2)cc1OC",
        "output": "206"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)O.O=C(O)COc1ncc(C(=O)Nc2ccc(F)cc2)cn1>>CC(C)OC(=O)COc1ncc(C(=O)Nc2ccc(F)cc2)cn1",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CO.Cc1nc(Cl)cc2c([N+](=O)[O-])cccc12.Cl[Ni]Cl.O.[BH4-].[Na+]>>Cc1nc(Cl)cc2c(N)cccc12",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1c1cccc(Oc2ccccc2)c1)C1CCCCC1)N(C)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1cccc(Oc2ccccc2)c1)C1CCCCC1",
        "output": "634"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)c1ccc(-c2ccccc2)cc1NC(=O)c1cc(C2CCCNC2)ccc1O.O=C(O)C(F)(F)F>>O=C(Nc1cc(-c2ccccc2)ccc1C(=O)O)c1cc(C2CCCNC2)ccc1O",
        "output": "752"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1=c2ccccc2=C(c2cccc3ccccc23)C(P(c2ccccc2)c2ccccc2)(P(c2ccccc2)c2ccccc2)C1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].Cc1ccccc1.FC(F)(F)c1ccc(-c2ccnc(Cl)c2)cc1.Nc1cccc2c1CC(O)CC2.[Na+].[Pd+2]>>OC1CCc2cccc(Nc3cc(-c4ccc(C(F)(F)F)cc4)ccn3)c2C1",
        "output": "434"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)Cc1c(F)cc2ncc(Br)cc2c1F.[Na+].[OH-]>>O=C(O)Cc1c(F)cc2ncc(Br)cc2c1F",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=C(c1cc(F)cc(OCc2ccccc2)c1)C1CCOCC1.[Pd]>>O=C(c1cc(O)cc(F)c1)C1CCOCC1",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)SCC(Cc1ccccc1)C(=O)Nc1cc(C)cc(C(=O)O)c1.CO.Cl.[Na+].[OH-]>>Cc1cc(NC(=O)C(CS)Cc2ccccc2)cc(C(=O)O)c1",
        "output": "90"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(C)=O.C[C@@H](CO)Nc1ncc(Br)cc1[N+](=O)[O-].Cl[Sn]Cl.O.O.[Na+].[OH-]>>C[C@@H](CO)Nc1ncc(Br)cc1N",
        "output": "269"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(c1cc(Cl)cc(Cl)c1)N(C)C(=O)CC(c1ccc(F)cc1)C1CCNCC1.CCN(C(C)C)C(C)C.COCCBr.O>>COCCN1CCC(C(CC(=O)N(C)C(C)c2cc(Cl)cc(Cl)c2)c2ccc(F)cc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CN(C)C=O.CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4N)sc3c2)ccn1>>CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4NC(C)=O)sc3c2)ccn1",
        "output": "339"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1cccc(Cn2ccc3cc(OCc4c(COc5c(C)cccc5C)noc4C(C)C)ccc32)c1.Cl.OCC1CCCO1.[Na+].[OH-]>>Cc1cccc(C)c1OCc1noc(C(C)C)c1COc1ccc2c(ccn2Cc2cccc(C(=O)O)c2)c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)c1c[nH]c2cc(Cl)c(-c3ccc(OCCCO)c(OC)c3)cc12.Cl.O.[Na+].[OH-]>>COc1cc(-c2cc3c(C(=O)O)c[nH]c3cc2Cl)ccc1OCCCO",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cccc2cccc(C=O)c12.Clc1cccc2c(C3CCNCC3)c[nH]c12>>Cc1cccc2cccc(CN3CCC(c4c[nH]c5c(Cl)cccc45)CC3)c12",
        "output": "567"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCN(CCCC)C(=O)c1n[nH]c(C)c1Cl.CN(C)C=O.COc1ccc(F)c(C#N)c1.O=C([O-])[O-].[Cs+].[Cs+]>>CCCCN(CCCC)C(=O)c1nn(-c2ccc(OC)cc2C#N)c(C)c1Cl",
        "output": "751"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CC(C)(C)OC(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(/C=C/Cl)CS[C@H]12.Cc1ccc(S(=O)(=O)O)cc1.O.O=C([O-])O.[Cl-].[Na+].[Na+]>>NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(/C=C/Cl)CS[C@H]12",
        "output": "431"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCc1nc(O)c2cc(Cl)ccc2n1.CCN(CC)CC.ClCCl.O=P(Cl)(Cl)Cl>>CCCc1nc(Cl)c2cc(Cl)ccc2n1",
        "output": "168"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(=O)(=O)Nn1c(=O)[nH]c2cc([N+](=O)[O-])c(F)cc2c1=O.N[C@@H](CO)c1ccccc1>>CS(=O)(=O)Nn1c(=O)[nH]c2cc([N+](=O)[O-])c(N[C@@H](CO)c3ccccc3)cc2c1=O",
        "output": "764"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)N1CC2(CC(=O)c3cc(/C=C/C(=O)OC)ccc3O2)C1.[Na+].[OH-]>>CCOC(=O)N1CC2(CC(=O)c3cc(/C=C/C(=O)O)ccc3O2)C1",
        "output": "58"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCNC(=O)Cc1ccc2c(c1)c(Cc1ccc(C(=O)O)cc1OC)cn2C.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cc1ccccc1S(N)(=O)=O.Cl.ClCCl>>CCCCNC(=O)Cc1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C",
        "output": "579"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCNCC1.O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)c1ccnc(F)c1>>CN1CCN(c2cc(C(=O)NCCC(c3ccc(F)cc3)c3ccc(F)cc3)ccn2)CC1",
        "output": "756"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=C(O)Cc1ccc(O)c(Cl)c1.O=S(Cl)Cl>>CCOC(=O)Cc1ccc(O)c(Cl)c1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CCCc1ccccn1.OO.[Na+].[OH-]>>CCCc1cccc[n+]1[O-]",
        "output": "396"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1cc[nH]c(=O)n1.O=C(Cl)c1ccccc1.c1ccncc1>>O=C(Nc1cc[nH]c(=O)n1)c1ccccc1",
        "output": "463"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccccc1Cc1nc2ccccc2[nH]1.O=c1cc(CBr)c2ccc(F)c(F)c2[nH]1>>Cc1ccccc1Cc1nc2ccccc2n1Cc1cc(=O)[nH]c2c(F)c(F)ccc12",
        "output": "593"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.Cc1cccc(C)n1.O=C([O-])O.OC(Cc1ccc(OC(F)(F)F)cc1)C(F)(F)F.[Na+]>>CC(C)(C)[Si](C)(C)OC(Cc1ccc(OC(F)(F)F)cc1)C(F)(F)F",
        "output": "839"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(Cl)CCCCCl.O=C1CCc2ccccc2N1>>O=C1CCc2cc(C(=O)CCCCCl)ccc2N1",
        "output": "31"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)c1cnn(C(C)(C)C)c1-c1cc(C)on1.[Na+].[OH-]>>Cc1cc(-c2c(C(=O)O)cnn2C(C)(C)C)no1",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CN(c1nc(C#N)nc(N(CCOCc2ccccc2)CCO[Si](C)(C)C(C)(C)C)c1[N+](=O)[O-])C1CCCC1.[Pd]>>CN(c1nc(C#N)nc(N(CCOCc2ccccc2)CCO[Si](C)(C)C(C)(C)C)c1N)C1CCCC1",
        "output": "660"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CNCC(O)COc1cccc2[nH]c3ccccc3c12.COc1ccc(C(=O)O)cc1OC.ClCCl.On1nnc2ccccc21>>COc1ccc(C(=O)N(C)CC(O)COc2cccc3[nH]c4ccccc4c23)cc1OC",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)N.CC(C)O.OCC1(CBr)COC1.[K+].[OH-]>>CC(C)NCC1(CO)COC1",
        "output": "147"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1=CCC(C(C)CC=O)CC1.CNCCO>>CC1=CCC(C(C)CCN(C)CCO)CC1",
        "output": "484"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C[Mg]Br.O=Cc1ccc(Br)cc1F>>CC(O)c1ccc(Br)cc1F",
        "output": "787"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CCSc1ccc2c(c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O.CO.O.O=S([O-])OO.[K+]>>CCN(CC)CCS(=O)(=O)c1ccc2c(c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O",
        "output": "730"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCCCN1C(=O)CCc2ccc(COC3CN(C(=O)OC(C)(C)C)CCC3c3ccc(O)cc3)cc21.N#CCCCBr>>COCCCN1C(=O)CCc2ccc(COC3CN(C(=O)OC(C)(C)C)CCC3c3ccc(OCCCC#N)cc3)cc21",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(c1ncccc1CO)S(C)(=O)=O.ClCCl.O=S(Cl)Cl>>CN(c1ncccc1CCl)S(C)(=O)=O",
        "output": "477"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CN(C)C=O.CN1CCn2c1cc(Cl)nc2=O.OCc1ccc(Oc2cc(F)c(F)c(F)c2)c(F)c1.[H-].[Na+]>>CN1CCn2c1cc(OCc1ccc(Oc3cc(F)c(F)c(F)c3)c(F)c1)nc2=O",
        "output": "653"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccccc1.C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOCC.OCCC1OCCO1.[H-].[I-].[Na+]>>c1ccc(COCCC2OCCO2)cc1",
        "output": "464"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Fc1ccc2c(CCCCl)noc2c1.O=C([O-])[O-].[K+].[K+].c1cc2c3c(c1)[C@@H]1CNCC[C@@H]1N3CCC2>>Fc1ccc2c(CCCN3CC[C@H]4[C@@H](C3)c3cccc5c3N4CCC5)noc2c1",
        "output": "138"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CC[C@H](N)C(=O)N1CCC(N2N=C(c3ccc(OC)c(OC)c3)[C@H]3CCCC[C@H]3C2=O)CC1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cc1[nH]c2c(-c3c(OCC4CC4)ccc4c3OCO4)ncnc2c1C(=O)O.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+]>>CC[C@H](NC(=O)c1c(C)[nH]c2c(-c3c(OCC4CC4)ccc4c3OCO4)ncnc12)C(=O)N1CCC(N2N=C(c3ccc(OC)c(OC)c3)[C@H]3CCCC[C@H]3C2=O)CC1",
        "output": "989"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O.O=C(c1ccc(Oc2ccc(Cl)cc2Cl)cc1)C(F)n1cncn1.[BH4-].[Na+]>>OC(c1ccc(Oc2ccc(Cl)cc2Cl)cc1)C(F)n1cncn1",
        "output": "24"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CCOC(=O)c1cc(Oc2cnc(N)cn2)c2cn(CC)nc2c1.ClCCl.c1ccncc1>>CCOC(=O)c1cc(Oc2cnc(NC(C)=O)cn2)c2cn(CC)nc2c1",
        "output": "399"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)C(=O)Cl.CCCn1c(COCC)nc2c(N)nc3ccc(OCCCCCCN)cc3c21.CCN(CC)CC.ClCCl.O>>CCCn1c(COCC)nc2c(N)nc3ccc(OCCCCCCNC(=O)C(C)C)cc3c21",
        "output": "45"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCO.Cn1c(=O)n(C2CCNCC2)c2cc(Cl)ccc21.FC(F)(F)c1ccc(-c2nn(CC3CO3)cc2-c2ccncc2)cc1>>Cn1c(=O)n(C2CCN(CC(O)Cn3cc(-c4ccncc4)c(-c4ccc(C(F)(F)F)cc4)n3)CC2)c2cc(Cl)ccc21",
        "output": "76"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN.Clc1nccnc1Nc1ccccc1>>CNc1nccnc1Nc1ccccc1",
        "output": "148"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)N[C@@H](CC(N)=O)C(=O)O.CN(C)C=O.CN1CCOCC1.C[C@H](N)C(=O)OCc1ccccc1.Cl.On1nnc2ccccc21>>C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1",
        "output": "132"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCC(=O)CCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)O.O=C([O-])O.[NH4+]>>CCC(=O)CCCCC[C@H](NC(=O)OC(C)(C)C)C(N)=O",
        "output": "313"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(=O)CC1.CCCCCCC.COc1ccc(Cl)cc1Br.O=S(=O)([O-])O.O=S(=O)([O-])[O-].[Li]CCCC.[Na+].[Na+].[Na+]>>COc1ccc(Cl)cc1C1(O)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "321"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCc1cccc(CNC[C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2cc(C)cc(C(=O)O)c2)c1.CO.Cl.ClCCl>>CCc1cccc(CN(C[C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2cc(C)cc(C(=O)O)c2)C(=O)OC(C)(C)C)c1",
        "output": "867"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COc1cc2ncnc(Nc3ccc(F)c(Cl)c3F)c2cc1[N+](=O)[O-].[Ni]>>COc1cc2ncnc(Nc3ccc(F)c(Cl)c3F)c2cc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Cc1ccc(CN=[N+]=[N-])cc1S(C)(=O)=O.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1ccc(CN)cc1S(C)(=O)=O",
        "output": "562"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)/N=N/C(=O)OCC.C[C@H](CO)N1C(=O)c2ccccc2C1=O.Oc1cc(F)ccc1F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C[C@H](COc1cc(F)ccc1F)N1C(=O)c2ccccc2C1=O",
        "output": "550"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1cc(Cl)ccc1NC(=O)c1cccc(-c2ccoc2)c1.Cl.[Na+].[OH-]>>O=C(Nc1ccc(Cl)cc1C(=O)O)c1cccc(-c2ccoc2)c1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COc1cc(-n2ccc3oc(-c4ccc(Cl)cc4)cc3c2=O)ccc1O.FC1(F)CC1CBr.O=C([O-])[O-].[K+].[K+]>>COc1cc(-n2ccc3oc(-c4ccc(Cl)cc4)cc3c2=O)ccc1OCC1CC1(F)F",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)c1ccc(CCl)cc1.CCC(=O)c1cc([N+](=O)[O-])ccc1O.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCC(=O)c1cc([N+](=O)[O-])ccc1OCc1ccc(C(C)(C)C)cc1",
        "output": "49"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#Cc1ccc(N(CC(=O)O)CC2CC2)cc1C(F)(F)F.[NH4+].c1ccncc1>>N#Cc1ccc(N(CC(N)=O)CC2CC2)cc1C(F)(F)F",
        "output": "313"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN.COC(=O)CC(c1ccc(OC)cc1)c1ccc2cc[nH]c2c1.C[Al](C)C.Cl.c1ccccc1>>CNC(=O)CC(c1ccc(OC)cc1)c1ccc2cc[nH]c2c1",
        "output": "392"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrC(Br)(Br)Br.C1CCOC1.OCCc1cccnc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>BrCCc1cccnc1",
        "output": "378"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.OCCCCCCCCCCCCCCCCCCCCCCO.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCCCCCCCCCCCCCCCCCCCCCO",
        "output": "193"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.Cc1ccc(-c2nc(C(F)(F)F)nc(NN)c2-c2ccccc2)cc1.Cl.ClCCl.c1ccncc1>>CC(=O)NNc1nc(C(F)(F)F)nc(-c2ccc(C)cc2)c1-c1ccccc1",
        "output": "450"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Cl.Cc1[nH]c2c(-c3cc(C(F)F)ccc3OCC3CC3)ncnc2c1C(=O)N[C@@H]1CC[C@@H](N)C[C@H]1F>>CC(=O)N[C@@H]1CC[C@@H](NC(=O)c2c(C)[nH]c3c(-c4cc(C(F)F)ccc4OCC4CC4)ncnc23)[C@H](F)C1",
        "output": "45"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc(C(=O)O)cc1-c1ccc2c(C(C)C)nncc2c1.F[P-](F)(F)(F)(F)F.NC1CC1>>Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(C(C)C)nncc2c1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(CCCN)OCC.Cc1ccccc1.O=C1OC(=O)c2ccccc21>>CCOC(CCCN1C(=O)c2ccccc2C1=O)OCC",
        "output": "341"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCC(=O)Cl.Cc1ccc(S(=O)(=O)n2ccc3ccccc32)cc1.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CCCCCC(=O)c1cn(S(=O)(=O)c2ccc(C)cc2)c2ccccc12",
        "output": "524"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COc1cc(N)ccc1C(C)(C)C#N.COc1ccc(C(=O)Cl)cc1OC.ClCCl>>COc1ccc(C(=O)Nc2ccc(C(C)(C)C#N)c(OC)c2)cc1OC",
        "output": "11"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.N[C@@H]1CC[C@@H](c2ccnc3ccc(F)cc23)CC1.O=C=Nc1ccc(Cl)cc1>>O=C(Nc1ccc(Cl)cc1)N[C@@H]1CC[C@@H](c2ccnc3ccc(F)cc23)CC1",
        "output": "35"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#CCCCCO.CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.ClCCl.c1c[nH]cn1>>C#CCCCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C",
        "output": "602"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCC.CCOC(C)=O.CN(C)C=O.COCCOCCOCCOS(C)(=O)=O.O=C([O-])[O-].Oc1cccc(I)c1.[K+].[K+]>>COCCOCCOCCOc1cccc(I)c1",
        "output": "702"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Nc1cccc(C(=O)O)c1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cc(Nc2ncc(C(C)N)nn2)cc(OC)c1OC.COc1cc(Nc2ncc(C(C)NC(=O)c3cccc(Br)c3)nn2)cc(OC)c1OC.F[P-](F)(F)(F)(F)F>>COc1cc(Nc2ncc(C(C)NC(=O)c3cccc(NC(C)=O)c3)nn2)cc(OC)c1OC",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCC.CCOC(C)=O.CN(C)c1ccncc1.ClCCl.O=C(Cl)CCl.O=C([O-])O.O[C@@H]1CCCC[C@H]1c1cc(Cl)ccc1OCc1ccccc1.[Na+]>>O=C(CCl)O[C@@H]1CCCC[C@H]1c1cc(Cl)ccc1OCc1ccccc1",
        "output": "126"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)N(C)C/C=C/C(=O)O.Cl.Oc1cccc(Nc2ncnc3sc4c(c23)CCNC4)c1>>CC(C)N(C)C/C=C/C(=O)N1CCc2c(sc3ncnc(Nc4cccc(O)c4)c23)C1",
        "output": "870"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CS(=O)(=O)c1cccc(CN)c1.F[B-](F)(F)F.O.O=C(O)c1ccc(B(O)O)cc1F>>CS(=O)(=O)c1cccc(CNC(=O)c2ccc(B(O)O)cc2F)c1",
        "output": "753"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=CCCOCCCCc1ccccc1.OCCCOCC(F)(F)c1ccccc1>>O=CCCOCC(F)(F)c1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)COc1ccc(CC(C)=O)cc1.COC(CN)c1cccc(F)c1F.[H][H].[Pt]>>COC(=O)COc1ccc(CC(C)NCC(OC)c2cccc(F)c2F)cc1",
        "output": "236"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N(c1cc(-c2cnc(C3(O[Si](C)(C)C(C)(C)C)CCC3)s2)cc([N+](=O)[O-])c1)c1nccc(C(F)(F)F)n1.CCOC(C)=O.[Pd]>>CC(C)(C)OC(=O)N(c1cc(N)cc(-c2cnc(C3(O[Si](C)(C)C(C)(C)C)CCC3)s2)c1)c1nccc(C(F)(F)F)n1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ncc(C(CN)C2CCOCC2)cn1.O=C(O)c1cccc(Cl)c1Cl>>Cc1ncc(C(CNC(=O)c2cccc(Cl)c2Cl)C2CCOCC2)cn1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCCCCC.CCOC(C)=O.CC[Mg]Cl.O.O=C1CCCN(Cc2ccccc2)CC1.OCc1ccccc1Br.[Cl-].[Mg].[NH4+]>>OCc1ccccc1C1(O)CCCN(Cc2ccccc2)CC1",
        "output": "321"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.ClCCl.O=C([O-])[O-].O=[N+]([O-])c1ccc(CBr)cc1.[K+].[K+]>>O=[N+]([O-])c1ccc(CN2CCOCC2)cc1",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1NCC12COC2.C1NCC12COC2.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.O.O=C(O)C(=O)O.O=Cc1ccc(O)cc1Cl.[Na+]>>Oc1ccc(CN2CC3(COC3)C2)c(Cl)c1",
        "output": "567"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Br.COc1cccc2c1OC(COS(=O)(=O)c1ccc(C)cc1)C2.O>>Cc1ccc(S(=O)(=O)OCC2Cc3cccc(O)c3O2)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CO.O.O=Cc1cc2cc([N+](=O)[O-])cnc2n1S(=O)(=O)c1ccccc1.[BH4-].[Na+]>>O=[N+]([O-])c1cnc2c(c1)cc(CO)n2S(=O)(=O)c1ccccc1",
        "output": "745"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CC[C@H](N)c1nc2cccc(Cl)c2c(=O)n1C1CC1.CO.ClCCl.Cn1cnc(-c2c(N)ncnc2Cl)n1>>CC[C@H](Nc1ncnc(N)c1-c1ncn(C)n1)c1nc2cccc(Cl)c2c(=O)n1C1CC1",
        "output": "110"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CO.N=CN.O=[N+]([O-])c1cccc(Cl)c1Cl.[H][H].[Ni]>>Nc1cccc(Cl)c1Cl",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.Nc1cc(C(F)(F)F)c(Br)cc1F.c1ccncc1>>CC(=O)Nc1cc(C(F)(F)F)c(Br)cc1F",
        "output": "6"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC1(O)CCN(Cc2cc(F)c(C(=O)OC(C)(C)C)cc2C2CC2)CC1.CCOC(C)=O.C[Si](C)(C)[N-][Si](C)(C)C.FC(F)(F)c1cc(Cl)ncc1Cl.[Li+]>>CC(C)(C)OC(=O)c1cc(C2CC2)c(CN2CCC(C)(Oc3cc(C(F)(F)F)c(Cl)cn3)CC2)cc1F",
        "output": "433"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CNc1cc(OC(F)(F)C(F)C(F)(F)F)nn1-c1cc(SCC(F)(F)F)c(C)cc1F.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>CNc1cc(OC(F)(F)C(F)C(F)(F)F)nn1-c1cc(S(=O)CC(F)(F)F)c(C)cc1F",
        "output": "500"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)COc1ccc(C=O)cc1-c1cc(F)cc(C#N)c1.CN.CO.O.[BH4-].[Na+]>>CNCc1ccc(OCC(=O)OC(C)(C)C)c(-c2cc(F)cc(C#N)c2)c1",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCCn1nnc2cc(C(=O)O)ccc21.O.[AlH4-].[Li+]>>CCCCn1nnc2cc(CO)ccc21",
        "output": "72"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(Cl)Cl.CCOC(=O)c1c(C(C)C)nn(C2CC2)c1C1=Cc2cc(OC)ccc2-c2c(C3CCCCC3)c3ccc(C(=O)OC(C)(C)C)cc3n2C1.O=C(O)C(F)(F)F>>CCOC(=O)c1c(C(C)C)nn(C2CC2)c1C1=Cc2cc(OC)ccc2-c2c(C3CCCCC3)c3ccc(C(=O)O)cc3n2C1",
        "output": "752"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CSCc1c(C)nc2c3cccc(Cl)c3ccn12.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>Cc1nc2c3cccc(Cl)c3ccn2c1CS(C)=O",
        "output": "13"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COc1cc2c(nc1OC)c(-c1cc3c(CO)ccnc3n1S(=O)(=O)c1ccc(C)cc1)cn2C.ClCCl.O=C([O-])O.O=S(Cl)Cl.[Na+]>>COc1cc2c(nc1OC)c(-c1cc3c(CCl)ccnc3n1S(=O)(=O)c1ccc(C)cc1)cn2C",
        "output": "81"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)N.CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.CN(C)C=O.Cc1c(F)cc(C(=O)O)cc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)cc1.Cl.F[P-](F)(F)(F)(F)F.O>>Cc1c(F)cc(C(=O)NC(C)C)cc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nn[nH]n3)cc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CCN(CC)CC.CN1CCN(c2ccc(C(=O)O)cc2F)CC1.N.O>>CN1CCN(c2ccc(C(N)=O)cc2F)CC1",
        "output": "358"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C(Cc1ccc(OCCNC(=O)c2ccc(-c3ccccc3)cc2)cc1)n1cccc1.CO.[Na+].[OH-]>>O=C(NCCOc1ccc(CC(C(=O)O)n2cccc2)cc1)c1ccc(-c2ccccc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)Cc1cccc(OC[C@@H]2COC(C)(C)O2)c1C.[Li+].[OH-]>>Cc1c(CC(=O)O)cccc1OC[C@@H]1COC(C)(C)O1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Nc1nc(C(F)(F)C(F)(F)F)c(I)s1.O=C(Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.c1ccncc1>>O=C(Nc1nc(C(F)(F)C(F)(F)F)c(I)s1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "673"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.c1ccc2cc(N3CCNCC3)ncc2c1>>CC(C)(C)OC(=O)N1CCN(c2cc3ccccc3cn2)CC1",
        "output": "694"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[Si](C)(C)Cl.ClCCl.Oc1ccc2[nH]ncc2c1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1ccc2[nH]ncc2c1",
        "output": "746"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.CC(O)CBr.CCCc1ccc(O)c2c(=O)cc(C(=O)OCC)oc12.O=C([O-])[O-].[K+].[K+]>>CCCc1ccc(OCC(C)O)c2c(=O)cc(C(=O)OCC)oc12",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)c1cc(C(=O)Cl)cc2c1OCC2(C)C.CCCN.ClCCl>>CCCNC(=O)c1cc(C(C)(C)C)c2c(c1)C(C)(C)CO2",
        "output": "271"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.Cc1ccccc1N1CCNCC1.ClCCl.O=C(O)CSc1ccccc1>>Cc1ccccc1N1CCN(C(=O)CSc2ccccc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1ccc2[nH]ncc2c1.CS(C)=O.II.O=S([O-])[O-].[K+].[Na+].[Na+].[OH-]>>CC(C)c1ccc2[nH]nc(I)c2c1",
        "output": "923"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Clc1ccc(Br)cn1.NCCO>>OCCNc1ccc(Br)cn1",
        "output": "70"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)COCCCOc1ccccc1CN(C(=O)c1ccc(-c2ccco2)cc1)C(C)C.O.O.[Li+].[OH-]>>CC(C)N(Cc1ccccc1OCCCOCC(=O)O)C(=O)c1ccc(-c2ccco2)cc1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrBr.Cc1ccc2c(C#N)c(-c3ccc(S(=O)(=O)N[C@H](C)C(F)(F)F)cn3)n(C3CCCC3)c2c1.O>>Cc1cc2c(cc1Br)c(C#N)c(-c1ccc(S(=O)(=O)N[C@H](C)C(F)(F)F)cn1)n2C1CCCC1",
        "output": "98"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1c(C#N)cccc1B(O)O.Nc1nc(Cl)cc(NC2CC2)n1>>Cc1c(C#N)cccc1-c1cc(NC2CC2)nc(N)n1",
        "output": "884"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNC1.CCc1nc2c(c(=O)n(Cc3ccc(Cl)cc3)c(=O)n2CCCBr)n1C.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCc1nc2c(c(=O)n(Cc3ccc(Cl)cc3)c(=O)n2CCCN2CCCC2)n1C",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CI.CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1c(O)cc(F)cc1F.[K+].[K+]>>COc1cc(F)cc(F)c1[N+](=O)[O-]",
        "output": "62"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.CCO.Cc1ccc(-c2nc(C(C)(C)C)oc2NC(=O)NCc2ccccc2Oc2ccnc(Cl)n2)cc1>>Cc1ccc(-c2nc(C(C)(C)C)oc2NC(=O)NCc2ccccc2Oc2ccnc(N3CCOCC3)n2)cc1",
        "output": "36"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(OC[C@@H](O)CN)cn1.O=C1CCN(c2ccc(CC3SC(=O)NC3=O)cc2)CC1>>Cc1ccc(OC[C@@H](O)CNC2CCN(c3ccc(CC4SC(=O)NC4=O)cc3)CC2)cn1",
        "output": "236"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COS(=O)(=O)OC.N.O.O=C([O-])[O-].O=[N+]([O-])c1cc(O)cc(Cl)c1.[K+].[K+]>>COc1cc(Cl)cc([N+](=O)[O-])c1",
        "output": "317"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1cnc(Nc2ccc(C)nc2)c(Cl)c1.Cl.[Na+].[OH-]>>Cc1ccc(Nc2ncc(C(=O)O)cc2Cl)cn1",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cnc(Cl)nc1-c1cnn(C(CC#N)CC2CCN(C(=O)OC(C)(C)C)CC2)c1.O=C(O)C(F)(F)F>>COc1cnc(Cl)nc1-c1cnn(C(CC#N)CC2CCNCC2)c1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CO1.CC1CCC2NC(C)(C)CC(C)C2C1.CCCCCCCCO>>CC1CCC2C(C1)C(C)CC(C)(C)N2CCO",
        "output": "76"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cc2c(=O)n(-c3ncc(OC)c(OC)n3)c(=S)[nH]c2cc1C(=O)O.F[P-](F)(F)(F)(F)F.NCc1ccncc1>>COc1cc2c(=O)n(-c3ncc(OC)c(OC)n3)c(=S)[nH]c2cc1C(=O)NCc1ccncc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2F)c2ccccc21.[Na+].[OH-]>>Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3ccccc3N(CC(=O)O)C2=O)c1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)O)ccc3C)c(F)c12.Cc1cc(C)nc(C2(N)CC2)n1.F[P-](F)(F)(F)(F)F>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5nc(C)cc(C)n5)CC4)ccc3C)c(F)c12",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CCCC[C@@H]1NC(=O)C(F)(F)F.CCO.[Na+].[OH-]>>CC(C)(C)OC(=O)N[C@@H]1CCCC[C@@H]1N",
        "output": "805"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Cl.ClCCN1CCCC1.FC(F)(F)c1nnc2ccc(N3CCC(c4c[nH]c5ccccc45)CC3)nn12.[H-].[Na+]>>FC(F)(F)c1nnc2ccc(N3CCC(c4cn(CCN5CCCC5)c5ccccc45)CC3)nn12",
        "output": "42"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc2ccccc2cc1B(O)O.Cc1ccccc1.Fc1ccc(Br)cc1I.O=C([O-])[O-].[Na+].[Na+]>>COc1cc2ccccc2cc1-c1cc(Br)ccc1F",
        "output": "855"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCOc1cnc(Cl)nc1.ClCCl.Cl[Pd]Cl.O=C([O-])[O-].OB(O)c1cccc(Cl)c1.[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOc1cnc(-c2cccc(Cl)c2)nc1",
        "output": "874"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(CCCCF)ccn1.O.O.[Li+].[OH-]>>O=C(O)c1cc(CCCCF)ccn1",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CN(C)C1CCN(c2ccc([N+](=O)[O-])cc2F)C1.[H][H].[Pd]>>CN(C)C1CCN(c2ccc(N)cc2F)C1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.CN1CCC(O)CC1.N#Cc1cccnc1F.O.[H-].[Na+]>>CN1CCC(Oc2ncccc2C#N)CC1",
        "output": "541"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CN2CCC(CC2)N1.COc1ccc(-c2cc(C(=O)O)n[nH]2)cc1.Cl.Cl>>COc1ccc(-c2cc(C(=O)N3CCN4CCC3CC4)n[nH]2)cc1",
        "output": "663"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.ClCCl.N.O=C(Cl)C(=O)Cl.O=C(O)c1c(Cl)cccc1I>>NC(=O)c1c(Cl)cccc1I",
        "output": "358"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1.[BH4-].[Na+]>>OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1",
        "output": "356"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Nc1cc2c(cc1C(=O)CCl)OCO2.CNC>>CC(=O)Nc1cc2c(cc1C(=O)CN(C)C)OCO2",
        "output": "414"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)c1cc2ccc(C#C[Si](C)(C)C)cc2s1>>C#Cc1ccc2cc(C(=O)OC)sc2c1",
        "output": "337"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)OC(=O)N=NC(=O)OC(C)C.CN1CCN(c2ccc(C(=O)Nc3nn(C(=O)OC(C)(C)C)c4cc(O)ccc34)cc2)CC1.CO.ClCCl.ClCCl.OCc1cccc(Oc2ccccc2)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN1CCN(c2ccc(C(=O)Nc3nn(C(=O)OC(C)(C)C)c4cc(OCc5cccc(Oc6ccccc6)c5)ccc34)cc2)CC1",
        "output": "347"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN.CO.COC(=O)C1CCN(c2ccc(Br)cc2)CC1>>CNC(=O)C1CCN(c2ccc(Br)cc2)CC1",
        "output": "392"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O=C1c2ccccc2C(=O)N1Cc1ccc([N+](=O)[O-])cc1F>>NCc1ccc([N+](=O)[O-])cc1F",
        "output": "418"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)C(=O)Cl.CCOC(C)=O.Nc1ccc2cn(-c3ccc(Cl)cc3)nc2c1.c1ccncc1>>CC(C)C(=O)Nc1ccc2cn(-c3ccc(Cl)cc3)nc2c1",
        "output": "9"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)N1CCC(N)CC1.CCN(C(C)C)C(C)C.ClCCl.O=C1c2ccccc2C(=O)N1CCS(=O)(=O)Cl>>CC(C)N1CCC(NS(=O)(=O)CCN2C(=O)c3ccccc3C2=O)CC1",
        "output": "493"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2cc(F)cc(F)c2c1Cl.Cc1ccccc1.Nc1cncc(N2CCOCC2)c1>>Cc1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2cc(F)cc(F)c2c1Nc1cncc(N2CCOCC2)c1",
        "output": "859"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNC1.CC(C)(C)c1ccc(C#N)s1.Nc1nc(-c2cccs2)nc2sc(C=O)cc12>>Nc1nc(-c2cccs2)nc2sc(CN3CCCC3)cc12",
        "output": "792"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCC(OC2CCNCC2)CC1.CN(C)C=O.Cl.Clc1ncc(Br)cn1.O=C([O-])[O-].[K+].[K+]>>Brc1cnc(N2CCC(OC3CCCCC3)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.C[Si](C)(C)CC[Si](C)(C)CCCOCC1CO1.NCC1CCCO1>>C[Si](C)(C)CC[Si](C)(C)CCCOCC(O)CNCC1CCCO1",
        "output": "16"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(O)cc1.Cc1cc(Nc2cc3c(C)cccc3c(Cl)n2)n[nH]1>>COc1ccc(Oc2nc(Nc3cc(C)[nH]n3)cc3c(C)cccc23)cc1",
        "output": "516"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CC1CC1.CCN(CC)CC.CN(C)C=O.Cc1cc(C(=O)C(=O)c2cccc(Br)c2)ccc1OC(F)F.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.N#N.[Cu]I>>Cc1cc(C(=O)C(=O)c2cccc(C#CC3CC3)c2)ccc1OC(F)F",
        "output": "659"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(O)CN.CCN(CC)CC.ClCCl.O=[N+]([O-])c1cnc2ccccc2c1Cl>>CC(C)(O)CNc1c([N+](=O)[O-])cnc2ccccc12",
        "output": "78"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=Cc1ccc(C)nc1.Cc1ccc2c3c([nH]c2c1)C1CCN3CC1>>Cc1ccc2c3c(n(CCc4ccc(C)nc4)c2c1)C1CCN3CC1",
        "output": "986"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCCC2)CC1.O=C(O)CNC(=O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(Br)cc2Cl)cc1>>O=C(CNC(=O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(Br)cc2Cl)cc1)N[C@@H]1CC[C@@H](CCN2CCCC2)CC1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(Cn2c3c(c(O)c(C(=O)O)c2=O)CCN(C(=O)OC(C)(C)C)c2cc4c(cc2-3)cc(CO)n4C)c(OC)c1.ClCCl.O=[Mn]=O>>COc1ccc(Cn2c3c(c(O)c(C(=O)O)c2=O)CCN(C(=O)OC(C)(C)C)c2cc4c(cc2-3)cc(C=O)n4C)c(OC)c1",
        "output": "263"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(CN)c1ccc(Cl)cc1Cl.Cl.N#CCc1ccc(Cl)cc1Cl.NC(=O)c1ccccc1NS(=O)(=O)c1c(F)cccc1F.O=C(O)c1ccc(Cl)cc1NS(=O)(=O)c1c(F)cccc1F>>CC(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1c(F)cccc1F)c1ccc(Cl)cc1Cl",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cc1sccc1C(=O)N1CCC(=O)c2ccc(Cl)cc21.Cl.NO.O.c1ccncc1>>Cc1sccc1C(=O)N1CCC(=NO)c2ccc(Cl)cc21",
        "output": "212"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(CCN1CCNCC1)C(=O)c1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1.CS(=O)(=O)Cl.ClCCl>>CN(CCN1CCN(S(C)(=O)=O)CC1)C(=O)c1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1",
        "output": "584"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCc1cc(-c2ccc(Cl)cc2)nc2c(C(=O)O)cnn12.Nc1cccc(S(N)(=O)=O)c1>>CCc1cc(-c2ccc(Cl)cc2)nc2c(C(=O)Nc3cccc(S(N)(=O)=O)c3)cnn12",
        "output": "969"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1ccc2c(c1)[nH]c1cc(O)ccc12.CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[K+].[K+]>>CC(C)(C)OC(=O)Nc1ccc2c(c1)[nH]c1cc(Oc3ccc([N+](=O)[O-])cc3)ccc12",
        "output": "564"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCc1cc2cc(OC)ccc2[nH]1.CN(C)C=O.O=P(Cl)(Cl)Cl>>CCc1[nH]c2ccc(OC)cc2c1C=O",
        "output": "266"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1oc(-c2ccccc2)nc1CCOS(C)(=O)=O.O=Cc1ccc(O)c(F)c1>>Cc1oc(-c2ccccc2)nc1CCOc1ccc(C=O)cc1F",
        "output": "702"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCO.FC(F)(F)c1ccc(-c2cc(Cl)ncn2)c(I)c1.Nc1cccc2c1CC(O)C2.O>>OC1Cc2cccc(Nc3cc(-c4ccc(C(F)(F)F)cc4I)ncn3)c2C1",
        "output": "161"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(=O)O.CCO.CCOP(C)(=O)c1ccc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(C(=O)NC)c4OC)c4ccccc34)ccn2)cc1OC.O.[Na+].[OH-]>>CNC(=O)c1cc(C(C)(C)C)cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(P(C)(=O)O)c(OC)c4)c3)c3ccccc23)c1OC",
        "output": "618"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.O[C@@H]1CO[C@@H]2COC(c3ccccc3)O[C@H]2C1.c1ccncc1>>Cc1ccc(S(=O)(=O)O[C@@H]2CO[C@@H]3COC(c4ccccc4)O[C@H]3C2)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc(-c2nc3cnc(Cl)cc3n2C(C)c2ccccn2)cn(C)c1=O.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.OCC1CC1.[H-].[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Cc1cc(-c2nc3cnc(OCC4CC4)cc3n2C(C)c2ccccn2)cn(C)c1=O",
        "output": "461"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CC(N2CCOCC2)CCN1.CCN(CC)CC.CN(C)C=O.Cc1c(C(=O)O)nn(C)c1-c1ccccc1-c1cc2ccccc2o1.ClCCl.O=C(Cl)C(=O)Cl>>Cc1c(C(=O)N2CCC(N3CCOCC3)CC2)nn(C)c1-c1ccccc1-c1cc2ccccc2o1",
        "output": "663"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=C([O-])O.O=C1CCCCc2ccc(Br)cc21.[BH4-].[Na+].[Na+]>>OC1CCCCc2ccc(Br)cc21",
        "output": "24"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(CC)CC.CCN(CC)CCNC.O=C([O-])O.O=[N+]([O-])c1ccc(F)c(Cl)c1.[Na+]>>CCN(CC)CCN(C)c1ccc([N+](=O)[O-])cc1Cl",
        "output": "26"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)N.O=S(=O)(Nc1cccc(-c2nc(N3CCOCC3)sc2-c2ccnc(Cl)n2)c1F)c1cc(F)ccc1F>>CC(C)Nc1nccc(-c2sc(N3CCOCC3)nc2-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)n1",
        "output": "544"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)C[C@H](NC(=O)CCC1CCc2cc3c(nc2C1)NCCC3)c1ccc2c(c1)OCC2.[Na+].[OH-]>>O=C(O)C[C@H](NC(=O)CCC1CCc2cc3c(nc2C1)NCCC3)c1ccc2c(c1)OCC2",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1cc(F)ccc1C#N.OC1CN(C(c2ccccc2)c2ccccc2)C1.[H-].[Na+]>>Cc1cc(OC2CN(C(c3ccccc3)c3ccccc3)C2)ccc1C#N",
        "output": "485"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1ccc(-c2ccc(C(C)=O)cc2C)cc1.ClCCl.O>>CC(=O)c1ccc(-c2ccc(O)cc2)c(C)c1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N(CC(=O)O)c1ccccc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1ccc(-c2ccncc2)cc1.O>>CC(C)(C)OC(=O)N(CC(=O)Nc1ccc(-c2ccncc2)cc1)c1ccccc1",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CN(Cc1c(Br)cccc1[N+](=O)[O-])C(=O)OC(C)(C)C.CO.NN>>CN(Cc1c(N)cccc1Br)C(=O)OC(C)(C)C",
        "output": "588"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCNCC.CCOC(=O)c1nc(C(=O)O)c(-c2ccc(S(=O)(=O)N[C@@H](C)C(F)(F)F)c(Cl)c2Cl)s1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O>>CCOC(=O)c1nc(C(=O)N(CC)CC)c(-c2ccc(S(=O)(=O)N[C@@H](C)C(F)(F)F)c(Cl)c2Cl)s1",
        "output": "747"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "FC(F)(F)c1ccc(CBr)c(Br)c1.O=Cc1ccc2[nH]ncc2c1>>O=Cc1ccc2c(cnn2Cc2ccc(C(F)(F)F)cc2Br)c1",
        "output": "635"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)S(=O)(=O)c1cccc2c1Sc1ccc(O)cc1N2.ClCc1ccccc1>>CN(C)S(=O)(=O)c1cccc2c1Sc1ccc(OCc3ccccc3)cc1N2",
        "output": "49"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)[O-].COc1ccccc1F.O.O=C=O.[K+].[Li]CCCC>>COc1cccc(C(=O)O)c1F",
        "output": "387"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCc1n[nH]cc1-c1cnc(NN)nn1.NNc1ncc(-c2ccccc2)nn1.O=C(O)Cc1c[nH]c2ccccc12.O=C(O)Cc1ccc2ncccc2c1>>CCCc1n[nH]cc1-c1cnc(NNC(=O)Cc2c[nH]c3ccccc23)nn1",
        "output": "459"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.COc1ccc(Cl)c(C)c1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COc1ccc(Cl)c(CBr)c1",
        "output": "29"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCCCCBr.OCCCc1ccncc1>>BrCCCCCCOCCCc1ccncc1",
        "output": "95"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CCNCC1.CO.O=Cc1ccc(C(=O)O)cc1.[H][H].[Pt]>>CN1CCN(Cc2ccc(C(=O)O)cc2)CC1",
        "output": "567"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(c1ccccc1-c1ccc(Cl)cc1)N1CCC2(CC1)OCCO2.Cl.O>>CC(c1ccccc1-c1ccc(Cl)cc1)N1CCC(=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCOCC.CNC(=O)/C(=N/OC)c1ccccc1Oc1cccc(O)c1.ClCCl.O=C(Cl)c1ccccc1>>CNC(=O)/C(=N/OC)c1ccccc1Oc1cccc(OC(=O)c2ccccc2)c1",
        "output": "482"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.O=C(c1ccc[nH]1)c1cc([N+](=O)[O-])ccc1Cl.O=C1CCC(=O)N1Br>>O=C(c1cc(Br)c[nH]1)c1cc([N+](=O)[O-])ccc1Cl",
        "output": "796"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOP(=O)(Cc1ccc(C(=O)Cl)cc1)OCC.ClCCl.Nc1nc2ccccc2s1.O=C([O-])O.[Na+].c1ccncc1>>CCOP(=O)(Cc1ccc(C(=O)Nc2nc3ccccc3s2)cc1)OCC",
        "output": "673"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)C(=O)CBr.CC(C)=O.CCC(CC)(c1ccc(O)c(C)c1)c1cc2cc(CO)ccc2o1.O=C([O-])[O-].[K+].[K+]>>CCC(CC)(c1ccc(OCC(=O)C(C)(C)C)c(C)c1)c1cc2cc(CO)ccc2o1",
        "output": "221"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)[C@@H]1C[C@@H](N)CN1C(=O)CN(C)C(=O)OC(C)(C)C>>COC(=O)[C@@H]1C[C@@H](NC(=O)OC(C)(C)C)CN1C(=O)CN(C)C(=O)OC(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=P(Cl)(Cl)Cl.[O-][n+]1cc(C2CC2)c2ccccc2c1>>Clc1ncc(C2CC2)c2ccccc12",
        "output": "2"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.C=CCBr.CC(C)(C)[O-].Cc1ncsc1CCO.O.[K+]>>C=CCOCCc1scnc1C",
        "output": "120"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.COC(=O)c1cc(Cc2c(C)c(OC)c(OC)c(OC)c2OC)ccc1OCc1cccnc1.Cl.O.[Na+].[OH-]>>COc1c(C)c(Cc2ccc(OCc3cccnc3)c(C(=O)O)c2)c(OC)c(OC)c1OC",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCOCC.CCc1ncc2n1CCN(C(=O)OC(C)(C)C)C2CCc1ccc(Br)cc1.CN(C)C=O.[C-]#N.[Ca+2].[K+].[OH-].[OH-].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCc1ncc2n1CCN(C(=O)OC(C)(C)C)C2CCc1ccc(C#N)cc1",
        "output": "65"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NC1(C(=O)O)CC1.CCN(CC)CC.CCOC(=O)N1c2ccccc2C=CC1OCC.ClC(Cl)Cl.Nc1ccc(Br)cc1>>CC(C)(C)OC(=O)NC1(C(=O)Nc2ccc(Br)cc2)CC1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(CCN1CCC[C@H]1C(=O)N(C)CCOCCOCCOCCC(=O)OC(C)(C)C)C(=O)c1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)N[C@H]3CCCc4ccccc43)ccn2)c1.O=C(O)C(F)(F)F>>CN(CCN1CCC[C@H]1C(=O)N(C)CCOCCOCCOCCC(=O)O)C(=O)c1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(C(=O)N[C@H]3CCCc4ccccc43)ccn2)c1",
        "output": "278"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.O=[N+]([O-])c1ccc(C(O)(CO)CO)cc1.[Pd]>>Nc1ccc(C(O)(CO)CO)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)[C@@H]1CC[C@@H](CN2C(=O)Cc3ccccc3C2=O)CC1>>CC(=O)N1CCN(C(=O)[C@@H]2CC[C@@H](CN3C(=O)Cc4ccccc4C3=O)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCOC(C)=O.Clc1ccc(Oc2cccc(N3CCOCC3)c2)cn1.Nc1cccc(OCc2ccccc2)c1.O=C([O-])[O-].[Cs+].[Cs+]>>c1ccc(COc2cccc(Nc3ccc(Oc4cccc(N5CCOCC5)c4)cn3)c2)cc1",
        "output": "434"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CC(=O)Cl.CC(CNC1CCCCCC1)N(CCc1ccc(O)c2[nH]c(=O)sc12)C(=O)OCc1ccccc1.CCN(CC)CC.C[Si](C)(C)Cl>>C=CC(=O)N(CC(C)N(CCc1ccc(O)c2[nH]c(=O)sc12)C(=O)OCc1ccccc1)C1CCCCCC1",
        "output": "135"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(C(=O)O)c(Cl)c1Cl.Cc1ccccc1.O=S(Cl)Cl>>Cc1ccc(C(=O)Cl)c(Cl)c1Cl",
        "output": "3"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.COC(=O)COc1cccnc1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OCCOc1cccnc1",
        "output": "343"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(NCc1ccc(F)cc1)C1(CCCCBr)c2ccccc2-c2ccccc21.c1ccc2nc(N3CCNCC3)ncc2c1>>O=C(NCc1ccc(F)cc1)C1(CCCCN2CCN(c3ncc4ccccc4n3)CC2)c2ccccc2-c2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClC(Cl)Cl.Nn1cnc2ccccc2c1=O.O=C(Cl)CC12CC3CC(CC(C3)C1)C2.c1ccncc1>>O=C(CC12CC3CC(CC(C3)C1)C2)Nn1cnc2ccccc2c1=O",
        "output": "450"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCN(CCC)CCCC#N.CCO.[H][H].[Na+].[Ni].[OH-]>>CCCN(CCC)CCCCN",
        "output": "246"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1cc(Br)c(=O)n(-c2ccccc2)c1C.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)c1cc(Br)c(=O)n(-c2ccccc2)c1CBr",
        "output": "590"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.Cc1nc(NC(=O)c2c(F)cccc2F)sc1-c1cccc(C(F)(F)F)c1>>Cc1nc(NCc2c(F)cccc2F)sc1-c1cccc(C(F)(F)F)c1",
        "output": "215"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCN1C(=O)C(O)(c2cc3c(cc2O)OCO3)c2c(Br)cccc21.CCCCCN1C(=O)C(O)(c2ccc(Br)cc2O)c2ccccc21>>CCCCCN1C(=O)C(c2ccc(Br)cc2O)c2ccccc21",
        "output": "964"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNCC1.CC(=O)c1c(O)c2ccccc2oc1=O.ClC(Cl)Cl.O=Cc1ccc(OC(F)(F)F)c(Cl)c1>>O=C(C=Cc1ccc(OC(F)(F)F)c(Cl)c1)c1c(O)c2ccccc2oc1=O",
        "output": "295"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=CCOc1ccc(OCC(C)N)cc1.CCOC(=O)Cl.CCOCC.c1ccncc1>>CCOC(=O)NC(C)COc1ccc(OCC=C(C)C)cc1",
        "output": "94"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(O)(c1ccoc1)c1cccc(Cl)c1.CN(C)C=O.C[Si](C)(C)Cl.O=C([O-])O.[Na+].c1c[nH]cn1>>CC(O[Si](C)(C)C)(c1ccoc1)c1cccc(Cl)c1",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.Cn1ccc2ncnc(Oc3ccc(N)c(Cl)c3)c21.NC1CC1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>Cn1ccc2ncnc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c21",
        "output": "913"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Clc1ccnc(Cl)n1.O=Cc1ccc(B(O)O)cc1.[Pd]>>O=Cc1ccc(-c2nccc(Cl)n2)cc1",
        "output": "874"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CCCC1=O.Cc1cc([N+](=O)[O-])ccc1F.NCCNCCO.O.O=C([O-])[O-].[K+].[K+]>>Cc1cc([N+](=O)[O-])ccc1NCCNCCO",
        "output": "572"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)CCC(=O)O.CO.C[C@@H](N)c1ccccc1.O=CO>>CC(CCC(=O)O)N[C@H](C)c1ccccc1",
        "output": "589"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Oc1cccc(I)c1OC(C)=O.C[C@@H]1CC[C@@H](CO)CN1C(=O)c1ccccc1-n1nccn1.ClCCl>>C[C@@H]1CC[C@@H](C=O)CN1C(=O)c1ccccc1-n1nccn1",
        "output": "142"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.ClCCl.O.c1ccc(C2c3ccccc3CC3CCNCCN32)cc1>>CC(=O)N1CCC2Cc3ccccc3C(c3ccccc3)N2CC1",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)C1(c2ccccc2)CCN(C(=O)c2ccc(-c3nc(C)no3)cc2)CC1.Cl.[K+].[OH-]>>Cc1noc(-c2ccc(C(=O)N3CCC(C(=O)O)(c4ccccc4)CC3)cc2)n1",
        "output": "203"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCOc1c(CNC(=O)OC(C)(C)C)n(CC(C)C)c(=O)c2ccc(OCc3ccccc3)cc12.CCO.[C].[Pd]>>CCCCOc1c(CNC(=O)OC(C)(C)C)n(CC(C)C)c(=O)c2ccc(O)cc12",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1ccc2cc[nH]c2c1.CI.CN(C)C=O.[H-].[Na+]>>Cn1ccc2ccc(Br)cc21",
        "output": "191"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)CCS(=O)(=O)N1CCNCC1.COc1cc(NC(=O)OC(C)(C)C)cc2c1nc(C(F)F)n2-c1nc(Cl)nc(N2CCOCC2)n1>>COc1cc(NC(=O)OC(C)(C)C)cc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(S(=O)(=O)CCN(C)C)CC2)n1",
        "output": "214"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.CCCCP(CCCC)CCCC.COC(=O)Cc1cccc(C)c1O.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>Cc1cccc(CC(=O)O)c1OCCCc1cn(-c2ccc(C(F)(F)F)cn2)nc1C(C)C",
        "output": "928"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.N#CCOc1cccc2[nH]c3ccccc3c12>>NCCOc1cccc2[nH]c3ccccc3c12",
        "output": "246"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1CCc2cc([N+](=O)[O-])ccc21.CO.[Pd]>>CN1CCc2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1cnc(Nc2cccc(Cl)c2)c2ccn(C)c12.[Na+].[OH-]>>Cn1ccc2c(Nc3cccc(Cl)c3)ncc(C(=O)O)c21",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.Nc1cccc(Cl)c1[N+](=O)[O-].O=C1CCC(=O)N1Br>>Nc1ccc(Br)c(Cl)c1[N+](=O)[O-]",
        "output": "4"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CCN1CCc2[nH]c(C=O)c(C)c2C1=O.O=CNc1ccc2c(c1)CC(=O)N2>>CCN(CC)CCN1CCc2[nH]c(C=C3C(=O)Nc4ccc(NC=O)cc43)c(C)c2C1=O",
        "output": "440"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COCCNc1ncc(Br)c([C@@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)(F)F)c3c2CCCC3)n1.CS(=O)(=O)c1ncc(Br)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)F)c3c2C(F)(F)CCC3(F)F)n1.NCC1CC1>>O=C(Cn1nc(C(F)F)c2c1C(F)(F)CCC2(F)F)N[C@@H](Cc1cc(F)cc(F)c1)c1nc(NCC2CC2)ncc1Br",
        "output": "629"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.CCCCBr.O.O=c1c2ccc(O)cc2oc2cc(O)ccc12>>CCCCOc1ccc2c(=O)c3ccc(O)cc3oc2c1",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.Nc1c(O)cccc1[N+](=O)[O-].O=C1CCC(=O)N1Cl>>Nc1c(O)cc(Cl)cc1[N+](=O)[O-]",
        "output": "121"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)CCc1cc(CCNC(=O)OC(C)(C)C)cc(Cc2cccnc2)c1.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)CCc1cc(CCN)cc(Cc2cccnc2)c1",
        "output": "538"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCCO.CN(C)C=O.COc1ccc(N2CCOCC2)c2sc(NC(=O)c3ccc(Cl)nc3)nc12.[H-].[Na+]>>CCCOc1ccc(C(=O)Nc2nc3c(OC)ccc(N4CCOCC4)c3s2)cn1",
        "output": "433"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C(=O)c1cc2cnc(Nc3ccc(C=O)cn3)nc2n1C1CCCC1.OC1CCNCC1>>CN(C)C(=O)c1cc2cnc(Nc3ccc(CN4CCC(O)CC4)cn3)nc2n1C1CCCC1",
        "output": "757"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOP(=O)(C#N)OCC.Cl.ClCCl.O.O=C(O)CCCCCc1ccc(F)cc1.c1cc2c(o1)CNCC2>>O=C(CCCCCc1ccc(F)cc1)N1CCc2ccoc2C1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COCCOC.Cn1nc(-c2c(F)cccc2Cl)nc1-c1ccc(CO)c(Cl)c1.FC(F)(F)c1ccc(Cl)nc1.O.[H-].[Na+]>>Cn1nc(-c2c(F)cccc2Cl)nc1-c1ccc(COc2ccc(C(F)(F)F)cn2)c(Cl)c1",
        "output": "433"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COC(=O)c1cc(Cl)ccc1Nc1ccc2c(c1)[nH]c(=O)n2Cc1ccccc1.Cl.O.[Na+].[OH-]>>O=C(O)c1cc(Cl)ccc1Nc1ccc2c(c1)[nH]c(=O)n2Cc1ccccc1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.ClCc1cccnc1.O=c1c(Cc2cccnc2)cn2c3c(cc(O)cc13)Sc1ccc(Br)cc1-2>>O=c1c(Cc2cccnc2)cn2c3c(cc(OCc4cccnc4)cc13)Sc1ccc(Br)cc1-2",
        "output": "678"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrP(Br)Br.CCOC(C)=O.COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CO)c1.COCCOC.O=C([O-])O.[Na+]>>COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CBr)c1",
        "output": "300"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C1CCOC1.CC(C)C[AlH]CC(C)C.COC(=O)c1cc(-c2cnc(C3CCCN3C(=O)OC(C)(C)C)[nH]2)ccc1Br>>CC(C)(C)OC(=O)N1CCCC1c1ncc(-c2ccc(Br)c(CO)c2)[nH]1",
        "output": "444"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#Cc1cc(Cl)ccc1OCC(=O)OC(C)(C)C.CC(C)Cc1ccncc1Br>>CC(C)Cc1ccncc1C#Cc1cc(Cl)ccc1OCC(=O)OC(C)(C)C",
        "output": "719"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)Cc1c(C)sc2cc(OCc3cc(C(F)(F)F)nn3C)cc(Cl)c12.Cl.[Na+].[OH-]>>Cc1sc2cc(OCc3cc(C(F)(F)F)nn3C)cc(Cl)c2c1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CCOC(C)=O.COc1ncccc1Nc1nc(Cl)ccc1[N+](=O)[O-].C[C@H](N)c1ccc(F)cn1.Cl>>COc1ncccc1Nc1nc(N[C@@H](C)c2ccc(F)cn2)ccc1[N+](=O)[O-]",
        "output": "70"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2ccnc(C)c2C#Cc2ccc(N)nc2)cc1.Cl.[Na+].[OH-]>>Cc1nccc(-c2ccc(C(=O)O)cc2)c1C#Cc1ccc(N)nc1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.N#Cc1ccc(CBr)cc1.N#Cc1ccc(CO)cc1.[H-].[Na+]>>N#Cc1ccc(COCc2ccc(C#N)cc2)cc1",
        "output": "464"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Oc1cc(-c2cccc(C(F)(F)F)c2)nc2c([N+](=O)[O-])cccc12.CCOC(C)=O.[Pd]>>CC(=O)Oc1cc(-c2cccc(C(F)(F)F)c2)nc2c(N)cccc12",
        "output": "269"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOc1ccc2c(c1)n(C1CCCCC1)c(=O)n2S(=O)(=O)c1ccc(NC(=O)Oc2ccccc2)cc1OC.CNC(C)(C)C.ClCCl>>CCOc1ccc2c(c1)n(C1CCCCC1)c(=O)n2S(=O)(=O)c1ccc(NC(=O)N(C)C(C)(C)C)cc1OC",
        "output": "525"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrBr.CC(=O)O.O.O=C(O)C1Cc2ccccc2O1.O=S([O-])O.[Na+]>>O=C(O)C1Cc2cc(Br)ccc2O1",
        "output": "98"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)c(F)c2)cc1.Cl.NO.O=C([O-])O.[Na+]>>Cc1ccccc1C(C/C(=N\\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)c(F)c2)cc1",
        "output": "966"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)N1CCC(Nc2nc(N(C)C)ccc2[N+](=O)[O-])CC1.CCOC(C)=O.[Pd]>>CCOC(=O)N1CCC(Nc2nc(N(C)C)ccc2N)CC1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrBr.COc1cccc(OC)c1C=O.ClCCl>>COc1ccc(Br)c(OC)c1C=O",
        "output": "98"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC(NCCN(C)C)c1nc2ncccc2c(=O)n1Cc1ccccc1.CCN(C(C)C)C(C)C.ClCCl.O=C(Cl)c1ccc(Br)cc1>>CCC(c1nc2ncccc2c(=O)n1Cc1ccccc1)N(CCN(C)C)C(=O)c1ccc(Br)cc1",
        "output": "201"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CO.O=C(O)c1ccc(Br)cc1Cl>>COC(=O)c1ccc(Br)cc1Cl",
        "output": "195"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.CO.ClCCl.O=C(NCc1ccc(F)cc1)c1nc(Br)ccc1OCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>O=C(NCc1ccc(F)cc1)c1nc(Br)ccc1O",
        "output": "264"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.NO.O=C1CC2CCC(C1)N2Cc1ccccc1>>ON=C1CC2CCC(C1)N2Cc1ccccc1",
        "output": "86"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.NN.O.O=C(O)c1ccc(Cl)nc1>>NNc1ccc(C(=O)O)cn1",
        "output": "417"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.Cc1oc(-c2ccc(Cl)nc2)nc1CCO.ClCCl>>Cc1ccc(S(=O)(=O)OCCc2nc(-c3ccc(Cl)nc3)oc2C)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)c1cc(C(C)C)[nH]n1.CN(C)C=O.O=C1CCC(=O)N1Cl>>CC(C)c1n[nH]c(C(C)C)c1Cl",
        "output": "856"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCNCC.O=C(c1ccc(Cl)nc1)c1cn(Cc2cccc(Br)n2)c2ccccc2c1=O>>CCN(CC)c1ccc(C(=O)c2cn(Cc3cccc(Br)n3)c3ccccc3c2=O)cn1",
        "output": "220"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCSCc1cc(-c2nn(C)c(OC(F)F)c2Cl)ccc1Cl.ClCCl.O=C(OO)c1cccc(Cl)c1>>CCS(=O)Cc1cc(-c2nn(C)c(OC(F)F)c2Cl)ccc1Cl",
        "output": "13"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cn(CC)c2c(F)c(F)c(F)cc2c1=O.Cl>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(F)c(F)c21",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NCC=O.CN(Cc1nc2ccccc2n1C[C@H]1CCCN(Cc2ccccn2)C1)[C@H]1CCCc2cccnc21.CN(Cc1nc2ccccc2n1C[C@H]1CCCNC1)[C@H]1CCCc2cccnc21>>CN(Cc1nc2ccccc2n1C[C@H]1CCCN(CCNC(=O)OC(C)(C)C)C1)[C@H]1CCCc2cccnc21",
        "output": "484"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COC(=O)c1ccc2c(n1)CCNC2.Cl.O=C=NCc1ccccc1>>COC(=O)c1ccc2c(n1)CCN(C(=O)NCc1ccccc1)C2",
        "output": "583"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O.CO.COc1cc(C(=O)N2C=C(c3ccc(NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)OCC4c5ccccc5-c5ccccc54)C(C)C)cc3)C[C@H]2CO[Si](C)(C)C(C)(C)C)c(NC(=O)OC(C)(C)C)cc1O[Si](C(C)C)(C(C)C)C(C)C.O>>COc1cc(C(=O)N2C=C(c3ccc(NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)OCC4c5ccccc5-c5ccccc54)C(C)C)cc3)C[C@H]2CO)c(NC(=O)OC(C)(C)C)cc1O[Si](C(C)C)(C(C)C)C(C)C",
        "output": "708"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OC[C@@H](Cn2ccc(N)n2)O1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.O=C(O)C(CCC(F)(F)F)N1CC(Oc2ccccc2Cl)=CC1=O>>CC1(C)OC[C@@H](Cn2ccc(NC(=O)C(CCC(F)(F)F)N3CC(Oc4ccccc4Cl)=CC3=O)n2)O1",
        "output": "795"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(C)(O)CNc1c([N+](=O)[O-])cnc2cc(Br)ccc12.Cc1ccccc1.[Pt]>>CC(C)(O)CNc1c(N)cnc2cc(Br)ccc12",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(CO)CC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CS(=O)(=O)c1ccc(-c2ccc(O)cc2)cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCC(COc2ccc(-c3ccc(S(C)(=O)=O)nc3)cc2)CC1",
        "output": "478"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)Nc1ccc([C@H](N)CO)cc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(C(c2ccccc2)c2ccccc2)s1>>CC(C)(C)OC(=O)Nc1ccc([C@@H](CO)NC(=O)c2ccc(C(c3ccccc3)c3ccccc3)s2)cc1",
        "output": "950"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1C(=O)[C@@H](NC(=O)C(CC(=O)c2ccc(Cl)cc2)c2ccc(F)cc2)N=C(c2ccccc2)c2ccccc21.[BH4-].[Na+]>>CN1C(=O)[C@@H](NC(=O)C(CC(O)c2ccc(Cl)cc2)c2ccc(F)cc2)N=C(c2ccccc2)c2ccccc21",
        "output": "24"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C(O)c1ccccc1.O=S(Cl)Cl>>O=C(Cl)c1ccccc1",
        "output": "3"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Brc1ccc(OC2CCOCC2)cc1.C1CCOC1.CCCCCC.O=Cc1cccc(C2(O)S[C@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)c1.[Cl-].[NH4+]>>OC(c1ccc(OC2CCOCC2)cc1)c1cccc(C2(O)S[C@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)c1",
        "output": "379"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)CCCc1cc(Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)nc(N)n1.[B-].[Na+]>>Nc1nc(CCCCO)cc(Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)n1",
        "output": "225"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.Nc1ccc2c(c1)-c1ccccc1C2=O.O=C(Cl)CCl>>O=C(CCl)Nc1ccc2c(c1)-c1ccccc1C2=O",
        "output": "9"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CC(=O)O.CN1CCN(c2cccc([N+](=O)[O-])c2)CC1>>CN1CCN(c2ccc(Br)c([N+](=O)[O-])c2)CC1",
        "output": "98"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)C(C#N)C1(c2ccc(Cl)cc2)CCC2(CC1)OCCO2.O.[K+].[OH-]>>N#CC(C(=O)O)C1(c2ccc(Cl)cc2)CCC2(CC1)OCCO2",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "FC(F)(F)C1NCCc2sccc21.O=C(O)c1cc2ncc(Br)cn2n1>>O=C(c1cc2ncc(Br)cn2n1)N1CCc2sccc2C1C(F)(F)F",
        "output": "663"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.CS(N)(=O)=O.Cc1ccc(N2CCOCC2)cc1C1CC(C)(C)c2cc(C(=O)O)ccc2N1.O.O=C(n1ccnc1)n1ccnc1.[H-].[Na+]>>Cc1ccc(N2CCOCC2)cc1C1CC(C)(C)c2cc(C(=O)NS(C)(=O)=O)ccc2N1",
        "output": "580"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCC[N+](CCC)(CCC)CCC.CCOc1c(/C(CC)=C(/F)CO)cc2c(c1Br)C(C)(C)CC=C2C(C)CC.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-]>>CCOc1c(/C(CC)=C(/F)C=O)cc2c(c1Br)C(C)(C)CC=C2C(C)CC",
        "output": "183"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Fc1ccc(Cl)cc1F.O=S(=O)(O)O.O=[N+]([O-])O>>O=[N+]([O-])c1cc(F)c(F)cc1Cl",
        "output": "21"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)O)c(C)c1.ClCCl.O=C([O-])O.OC1(c2ccncc2)CCNCC1.[Na+]>>COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(O)(c3ccncc3)CC2)c(C)c1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOc1ccc(Nc2ncnc3c(N4CCS(=O)CC4)nc(Cl)nc23)cc1.NCCO>>CCOc1ccc(Nc2ncnc3c(N4CCS(=O)CC4)nc(NCCO)nc23)cc1",
        "output": "544"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)c1ccncc1.CS(=O)(=O)Cl.Cc1cc(F)ccc1-c1cc(N2CC[C@H](N)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.ClCCl>>Cc1cc(F)ccc1-c1cc(N2CC[C@H](NS(C)(=O)=O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "493"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCCC(c2cc(-c3ccccc3OCc3ccccc3)nc(N)c2C#N)C1.CCOC(C)=O>>CC(C)(C)OC(=O)N1CCCC(c2cc(-c3ccccc3O)nc(N)c2C#N)C1",
        "output": "23"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)[C@H]1O[C@@H]1C(=O)OCC.[K+].[OH-]>>CCOC(=O)[C@H]1O[C@@H]1C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.COC(=O)c1ccc(-c2ccncc2)cc1.[Li+].[OH-]>>O=C(O)c1ccc(-c2ccncc2)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCO.COc1ccc(C#N)c(CBr)c1.O.[C-]#N.[K+]>>COc1ccc(C#N)c(CC#N)c1",
        "output": "39"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCc1ccc(Br)cc1.CC(=O)N(C)C.O.O=C([O-])[O-].OC1CCNCC1.[K+].[K+]>>OC1CCN(Cc2ccc(Br)cc2)CC1",
        "output": "248"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.COc1ccc2c(c1)Cc1ccccc1-2.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc2c(c1)Cc1cc(C(C)=O)ccc1-2",
        "output": "31"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)[C@@H]1C[C@@H]2CC[C@H]1O2.[BH4-].[Na+]>>OC[C@@H]1C[C@@H]2CC[C@H]1O2",
        "output": "225"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.N#Cc1cc(CC=O)ccc1F>>N#Cc1cc(CCO)ccc1F",
        "output": "223"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.O.O=[N+]([O-])c1ccccc1S(=O)(=O)Nc1cccc(SC(F)(F)F)c1.[Pd]>>Nc1ccccc1S(=O)(=O)Nc1cccc(SC(F)(F)F)c1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=C(O)Cc1ccc([N+](=O)[O-])cc1.O=S(Cl)Cl.c1ccccc1>>O=C(Cl)Cc1ccc([N+](=O)[O-])cc1",
        "output": "53"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)N(C)C.CCC(=O)Cl.CO.Cc1cccnc1C(=O)Nc1cccc(Oc2ccc3nc(N)cn3c2)c1.O=C([O-])[O-].[Na+].[Na+]>>CCC(=O)Nc1cn2cc(Oc3cccc(NC(=O)c4ncccc4C)c3)ccc2n1",
        "output": "399"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=Cc1ccc(OC)cc1.CN1CCCC1=O.COCCOCCN(CCOCCOC)CCOCCOC.Cl[Pd]Cl.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Br)c(C(F)(F)F)c1.[K+].[K+]>>COc1ccc(C=Cc2ccc([N+](=O)[O-])cc2C(F)(F)F)cc1",
        "output": "539"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(O)Cn1nc2c3c(ccc([N+](=O)[O-])c31)CCC2.CCO>>CC(O)Cn1nc2c3c(ccc(N)c31)CCC2",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CO.COC(=O)[C@H]1CCCC[C@H]1N.O=Cc1ccc(F)cc1.[BH3-]C#N.[Na+]>>COC(=O)[C@H]1CCCC[C@H]1NCc1ccc(F)cc1",
        "output": "468"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCN.CS(C)=O.[O-][n+]1c(Cl)cccc1Cl>>CCCCNc1cccc(Cl)[n+]1[O-]",
        "output": "70"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCSc1ccc(C(=O)C(=O)OCC)[nH]1.Cl.O.[Na+].[OH-]>>CCCSc1ccc(C(=O)C(=O)O)[nH]1",
        "output": "472"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.Br.CC1(N)CC1(C)N.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.Cc1cc(OCc2c(F)cccc2F)n2nc(C)c(C(=O)O)c2c1.ClCCl.F[P-](F)(F)(F)(F)F>>Cc1cc(OCc2c(F)cccc2F)n2nc(C)c(C(=O)NC3(C)CC3(C)N)c2c1",
        "output": "621"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C(CO)Nc1cc2c(cc1F)CC(=O)N2.O=Cc1[nH]c2c(c1-c1ccc(F)cc1)C(=O)NCC2>>O=C(CO)Nc1cc2c(cc1F)C(=Cc1[nH]c3c(c1-c1ccc(F)cc1)C(=O)NCC3)C(=O)N2",
        "output": "440"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CNc1nc(OCC(F)F)c(C(=O)Nc2ccc(Br)cc2)cc1[N+](=O)[O-].[Ni]>>CNc1nc(OCC(F)F)c(C(=O)Nc2ccc(Br)cc2)cc1N",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=[N+]=[N-].CC(=O)O.CCOCC.O=C(O)c1ccc[nH]1>>COC(=O)c1ccc[nH]1",
        "output": "60"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)S(=O)(=O)c1c(Cl)ccc(N)c1O.NC(N)=S.S=C=Nc1ccccc1Cl>>CN(C)S(=O)(=O)c1c(Cl)ccc(NC(=S)Nc2ccccc2Cl)c1O",
        "output": "474"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc(C)nc1Nc1cccc([N+](=O)[O-])c1.O.[BH4-].[Cl-].[K+].[Li+]>>Cc1ccc(CO)c(Nc2cccc([N+](=O)[O-])c2)n1",
        "output": "522"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNOC.C[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.F[P-](F)(F)(F)(F)F>>CON(C)C(=O)[C@H](C)NC(=O)OC(C)(C)C",
        "output": "54"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCC.CCOCC.CN1CCN(C(=O)CN(C(=O)OC(C)(C)C)[C@@H]2C[C@H]2c2ccc(-c3ccccc3)cc2)CC1.Cl>>CN1CCN(C(=O)CN[C@@H]2C[C@H]2c2ccc(-c3ccccc3)cc2)CC1",
        "output": "634"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CI.CN(C)C=O.C[O-].O.Oc1ccc(Br)nc1F.[Na+]>>COc1ccc(Br)nc1F",
        "output": "661"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1csc(C2CC[NH2+]CC2)n1.Cc1cc(C)n(C(C)(C)C(=O)O)n1.[Cl-]>>CCOC(=O)c1csc(C2CCN(C(=O)C(C)(C)n3nc(C)cc3C)CC2)n1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.ClCCl.Cn1cc2c3c(c(C(=O)O)[nH]c3c1=O)CN(c1ccc(Cl)cc1)c1ccc(CS(C)(=O)=O)cc1-2.O=C(Cl)C(=O)Cl.[NH4+].[OH-]>>Cn1cc2c3c(c(C(N)=O)[nH]c3c1=O)CN(c1ccc(Cl)cc1)c1ccc(CS(C)(=O)=O)cc1-2",
        "output": "136"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C(=O)Cl)c1ccccc1.CCN(CC)CC.Cc1nc(N)c(C)c(C)c1OCc1ccccc1.ClCCl>>CCC(C(=O)Nc1nc(C)c(OCc2ccccc2)c(C)c1C)c1ccccc1",
        "output": "332"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)COc1ccccc1S(N)(=O)=O.CCOC(C)=O.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.OCCO>>CC1(COc2ccccc2S(N)(=O)=O)OCCO1",
        "output": "265"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O.CN(C)c1ccncc1.ClCCl.OCCO>>CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)OCCO",
        "output": "47"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCNCC(O)(CNc1cccc2c1cnn2-c1ccc(F)cc1)C(F)(F)F.O=C(O)c1ccccc1>>CCN(CC(O)(CNc1cccc2c1cnn2-c1ccc(F)cc1)C(F)(F)F)C(=O)c1ccccc1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OCCOc1ccccc1.CC(C)C(=O)Cl.Cl.ClCCl.O.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)OCCOc1ccc(C(=O)C(C)C)cc1",
        "output": "31"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nn1nc(C2CCCCC2)c2ccccc2c1=O.O=C(Cl)CC12CC3CC(CC(C3)C1)C2>>O=C(CC12CC3CC(CC(C3)C1)C2)Nn1nc(C2CCCCC2)c2ccccc2c1=O",
        "output": "450"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.O.O=[N+]([O-])c1ccccc1CCBr.[N-]=[N+]=[N-].[Na+]>>[N-]=[N+]=NCCc1ccccc1[N+](=O)[O-]",
        "output": "622"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.Cl.O.O=C(Cl)c1ccccc1.O=C(O)c1ccc(O)cc1.[Na+].[OH-]>>O=C(O)c1ccc(OC(=O)c2ccccc2)cc1",
        "output": "482"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CO.Cc1cc(C#N)ccc1N1CCNCC1>>Cc1cc(C#N)ccc1N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "694"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C[C@H](N[C@@H](c1ccc(Br)cc1)c1nccs1)C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.N#CCN>>CC(C)C[C@H](N[C@@H](c1ccc(Br)cc1)c1nccs1)C(=O)NCC#N",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(=O)[C@@H]1COCC[C@H]1N>>CCOC(=O)[C@@H]1COCC[C@H]1NC(=O)OC(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1ccc(C=C(Cn2cncc2C)c2ccc(F)cc2)cc1-c1ccccc1.[Na+].[OH-]>>Cc1cncn1CC(=Cc1ccc(C(=O)O)c(-c2ccccc2)c1)c1ccc(F)cc1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCOCCCN.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)O)ccc21.F[P-](F)(F)(F)(F)F>>CCOCCCNC(=O)c1ccc2c(c1)nc(Nc1nc3ccc(OC(F)(F)F)cc3s1)n2C",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)OC[C@H](c1ccc(Cl)cc1)N(C(=O)C1CCOCC1)C2.NO.[Na+].[OH-]>>O=C(NO)c1ccc2c(c1)OC[C@H](c1ccc(Cl)cc1)N(C(=O)C1CCOCC1)C2",
        "output": "988"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.ClCCl.N[C@@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1O.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)O[C@H]1CN(C(=O)OCc2ccccc2)C[C@H]1N",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc2nncc(-c3cnc(N4CCC5(CC4)OCCO5)c(C)c3)c2cc1OC.ClCCl.O=C(O)C(F)(F)F>>COc1cc2nncc(-c3cnc(N4CCC(=O)CC4)c(C)c3)c2cc1OC",
        "output": "251"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)O)cc(F)c3C)c(F)c12.Cl.Cl.F[P-](F)(F)(F)(F)F.NC1(c2ccccn2)COC1.O>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5ccccn5)COC4)cc(F)c3C)c(F)c12",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1nc(-c2cccc(F)c2)c(-c2ccncc2)c(=O)[nH]1.O=P(Cl)(Cl)Cl>>Nc1nc(Cl)c(-c2ccncc2)c(-c2cccc(F)c2)n1",
        "output": "14"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COc1cc(N2CCN(S(C)(=O)=O)CC2)ccc1[N+](=O)[O-].[BH4-].[Na+]>>COc1cc(N2CCN(S(C)(=O)=O)CC2)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.N#Cc1cc(C=O)ccc1F.O.OC1CCCC1.[Cl-].[H-].[Na+].[Na+]>>N#Cc1cc(C=O)ccc1OC1CCCC1",
        "output": "485"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(CN)c1coc(-c2ccc(F)cc2)n1.O=C(O)c1cccc(-c2noc(C(F)(F)F)n2)c1>>CC(C)(CNC(=O)c1cccc(-c2noc(C(F)(F)F)n2)c1)c1coc(-c2ccc(F)cc2)n1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cc1ccc(S(=O)(=O)O)cc1.O=C(O)CCCCCCCCCCBr.O=C([O-])O.[Na+]>>CCOC(=O)CCCCCCCCCCBr",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3CC(F)(F)C[C@@H]3[C@H]2CN)c1.Cc1nc2sccn2c1C(=O)O>>Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3CC(F)(F)C[C@@H]3[C@H]2CNC(=O)c2c(C)nc3sccn23)c1",
        "output": "697"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccc(-n2c3ccccc3c3ccc4ccccc4c32)cc1.Cc1cc(C)c(C(=O)Cl)c(C)c1.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)c1ccc(-n2c3ccccc3c3cc(C(=O)c4c(C)cc(C)cc4C)c4ccccc4c32)cc1",
        "output": "61"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(Cl)Cl.CCCS(=O)(=O)Cl.CCN(C(C)C)C(C)C.COC(=O)Cc1cccc(CN)c1.Cl>>CCCS(=O)(=O)NCc1cccc(CC(=O)OC)c1",
        "output": "742"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCCCCCC.CCN(CC)C(=O)c1ccccc1O.CCOC(C)=O.Cc1cc(C)cc(Br)c1.O.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+].[NH4+].[OH-].c1ccc2[nH]ccc2c1>>Cc1cc(C)cc(-n2ccc3ccccc32)c1",
        "output": "349"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.CCOC(=O)/C=C/c1cnc(-c2ccc(OCc3ccccc3)c(C34CC5CC(CC(C5)C3)C4)c2)cn1.ClCCl>>CCOC(=O)/C=C/c1cnc(-c2ccc(O)c(C34CC5CC(CC(C5)C3)C4)c2)cn1",
        "output": "23"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Cc1cc(C(C)(C)N=[N+]=[N-])ccc1Cl.O.O=[Pt]=O.[N-]=[N+]=[N-]>>Cc1cc(C(C)(C)N)ccc1Cl",
        "output": "562"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCC1=C(c2ccccc2)C(=O)N(C(C)(C)C(=O)OC(C)(C)C)CO1.ClCCl.O=C(O)C(F)(F)F>>COCC1=C(c2ccccc2)C(=O)N(C(C)(C)C(=O)O)CO1",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Fc1cccc(OCCCOCc2ccccc2)c1Nc1nc(Cl)ncc1Cl.Nc1ccc2c(c1)NC(=O)CCC2>>O=C1CCCc2ccc(Nc3ncc(Cl)c(Nc4c(F)cccc4OCCCOCc4ccccc4)n3)cc2N1",
        "output": "808"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCc1cccc(-n2cccc2)c1>>CS(=O)(=O)OCc1cccc(-n2cccc2)c1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)[C@H]1CCNC1.O=C(NCC1(O)CCC(F)(F)CC1)c1c(Cl)ccc2nc(Cl)ccc12>>CN(C)[C@H]1CCN(c2ccc3c(C(=O)NCC4(O)CCC(F)(F)CC4)c(Cl)ccc3n2)C1",
        "output": "220"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CC(C)O.COC(=O)c1ccc(OC)c(I)n1.Cc1ccccc1.O.[H-]>>COc1ccc(CO)nc1I",
        "output": "546"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cccc2c(CCN)c[nH]c12.O=CC1CC1>>COc1cccc2c(CCNCC3CC3)c[nH]c12",
        "output": "426"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)[O-].O.O=c1[nH]cnc2cc(F)cc(F)c12.OC1CCOCC1.[K+]>>O=c1[nH]cnc2cc(F)cc(OC3CCOCC3)c12",
        "output": "958"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.Nc1cn2nc(I)ccc2n1.O=C(Cl)C1CC1>>O=C(Nc1cn2nc(I)ccc2n1)C1CC1",
        "output": "399"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(Cc2ccon2)CC1.ClCCl.O=C(O)C(F)(F)F>>c1cc(CN2CCNCC2)no1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCOCC.O=C1CCC(=O)N1Br.c1ccc2c(c1)CCCN2>>Brc1ccc2c(c1)CCCN2",
        "output": "4"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cc(Br)cc2c1OCCCC2.[K+].[OH-]>>O=C(O)c1cc(Br)cc2c1OCCCC2",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CO.COC(=O)CCN.COC(=O)c1ncc2c(cc(-c3cnc(N(C)C)nc3)c(=O)n2Cc2ccccc2)c1O.Cl.ClCCCl.On1nnc2ccccc21.[Na+].[OH-]>>COC(=O)CCNC(=O)c1ncc2c(cc(-c3cnc(N(C)C)nc3)c(=O)n2Cc2ccccc2)c1O",
        "output": "487"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCC/C(=C\\C=C\\C(=O)OC)c1cccc(F)c1.CO.[Na+].[OH-]>>CCCCC/C(=C\\C=C\\C(=O)O)c1cccc(F)c1",
        "output": "58"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCC1=C(/C=C/C(=O)OC)CCc2cc(OC)ccc21.CO.[Na+].[OH-]>>CCCCC1=C(/C=C/C(=O)O)CCc2cc(OC)ccc21",
        "output": "58"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C(=O)OC(C)(C)C)C1CCN(c2nnc(-c3ccnn3C)c3ccncc23)CC1.O=C(O)C(F)(F)F>>CNC1CCN(c2nnc(-c3ccnn3C)c3ccncc23)CC1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.N[C@@H](CCCNC(=O)OCc1ccccc1)CNC(=O)C(Cc1ccccc1)Cc1ccccc1.[OH-].[OH-].[Pd+2]>>NCCC[C@H](N)CNC(=O)C(Cc1ccccc1)Cc1ccccc1",
        "output": "574"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(C)=O.COC(=O)CCC1(C)CCc2cc(O)c3c(c2O1)C1CCC3C1.Cl.O.[Na+].[OH-]>>CC1(CCC(=O)O)CCc2cc(O)c3c(c2O1)C1CCC3C1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(OC)OC.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O.O=C1CCC(NC(=O)OCc2ccccc2)CC1.OCCO>>O=C(NC1CCC2(CC1)OCCO2)OCc1ccccc1",
        "output": "265"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CCOC[C@@H]1CC(c2ccc(Br)cn2)=NO1.CC1(C)OB(c2ccc(N3C[C@H](Cn4ccnn4)OC3=O)cc2F)OC1(C)C.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+].c1ccc([PH](c2ccccc2)(c2ccccc2)[Pd-4]([PH](c2ccccc2)(c2ccccc2)c2ccccc2)([PH](c2ccccc2)(c2ccccc2)c2ccccc2)[PH](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>C=CCOC[C@@H]1CC(c2ccc(-c3ccc(N4C[C@H](Cn5ccnn5)OC4=O)cc3F)cn2)=NO1",
        "output": "938"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CC2(CCN2)C1.CCN(CC)CC.O=C(O)C(=O)O.O=C=NCc1ccc(Cl)cc1Cl>>CC(C)(C)OC(=O)N1CC2(CCN2C(=O)NCc2ccc(Cl)cc2Cl)C1",
        "output": "583"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCCN(C)C.COC(=O)/C=C/c1cccc(N)c1.Cl.ClCCl.Cn1cccc1C(=O)O.O.c1ccncc1>>COC(=O)/C=C/c1cccc(NC(=O)c2cccn2C)c1",
        "output": "548"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(NC(=O)N[C@]2(c3ccc(OC(F)(F)F)c(F)c3)CCOc3cccnc32)cc1.Cl.O.[Li+].[OH-]>>O=C(Nc1ccc(C(=O)O)cc1)N[C@]1(c2ccc(OC(F)(F)F)c(F)c2)CCOc2cccnc21",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C(=O)N1CCN(Cc2ccccc2)CC1)c1ccccc1F.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(CN1CCN(Cc2ccccc2)CC1)c1ccccc1F",
        "output": "112"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)C(C)(O)c1ccc(-c2ccccc2)cc1.[Na+].[OH-]>>CC(O)(C(=O)O)c1ccc(-c2ccccc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#CCBr.CC(C)=O.CCCc1cc2c(cc1O)OCC2.O=C([O-])[O-].[K+].[K+]>>CC#CCOc1cc2c(cc1CCC)CCO2",
        "output": "154"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.CNS(=O)(=O)c1c(Cl)ccc(N)c1O.O=C=Nc1cccc(Cl)c1Cl>>CNS(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2cccc(Cl)c2Cl)c1O",
        "output": "473"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4CNCC(C)c4ccccc4)cc3)cc2)CC1.O=C(Cl)c1ccccc1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4CN(CC(C)c4ccccc4)C(=O)c4ccccc4)cc3)cc2)CC1",
        "output": "201"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cccc(C(=O)O)c1C.NCC1(c2cccnc2)CCCC1>>Cc1cccc(C(=O)NCC2(c3cccnc3)CCCC2)c1C",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.COC(=O)c1c(O)c2c(n(Cc3ccc(OC)cc3OC)c1=O)-c1ccc(N(C)C)cc1CCC2.Cl.[I-].[Li+]>>COc1ccc(Cn2c3c(c(O)c(C(=O)O)c2=O)CCCc2cc(N(C)C)ccc2-3)c(OC)c1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N1CCNCC1.COc1ccc2[nH]c3c(c2c1)CC1(C)C(=O)N(CCBr)C(=O)N1C3c1cccc(O)c1>>COc1ccc2[nH]c3c(c2c1)CC1(C)C(=O)N(CCN2CCN(C(C)=O)CC2)C(=O)N1C3c1cccc(O)c1",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cl.Nc1ccc(N2CCC(=O)CC2)cc1.O=S(=O)(Cl)c1ccc(-c2ccccn2)s1>>O=C1CCN(c2ccc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)cc2)CC1",
        "output": "861"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)C1(N(C(=O)c2ccco2)c2cccc(NC(C)=O)c2)CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Cl-].[Na+].[Na+]>>COC(=O)C1(N(C(=O)c2ccco2)c2cccc(NC(C)=O)c2)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OCCCCCl.CCO.Sc1ccc(Cl)cc1.[Na+].[OH-]>>CC(=O)OCCCCSc1ccc(Cl)cc1",
        "output": "460"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.CO.Cl.O=C(O)c1cc(F)c(Cl)cc1Cl.[H-].[Na+]>>COc1cc(C(=O)O)c(Cl)cc1Cl",
        "output": "485"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(C)=O.O=Cc1cc(OC(F)(F)F)ccc1OCc1ccccc1.[BH4-].[Cl-].[NH4+].[Na+]>>OCc1cc(OC(F)(F)F)ccc1OCc1ccccc1",
        "output": "356"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CNCCN1.O=C(O)c1cn(C2CC2)c2c(F)c(F)c(Cl)cc2c1=O.c1ccncc1>>O=C(O)c1cn(C2CC2)c2c(F)c(N3CCNCC3)c(Cl)cc2c1=O",
        "output": "676"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)c1ccncc1.COC(=O)c1cncc(N)c1.COc1ccc(Br)cc1S(=O)(=O)Cl.c1ccncc1>>COC(=O)c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC)c1",
        "output": "554"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C1COCCO1.CN1CCN(c2ccc([N+](=O)[O-])c(NCc3ccccc3)c2)CC1.CO.Cl.[Ni]>>CN1CCN(c2ccc(N)c(NCc3ccccc3)c2)CC1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COC(=O)C1CCOc2cc(Oc3ccc(C(=O)Nc4nnc(-c5ccccc5)s4)cc3)c(C#N)cc21.Cl.[Na+].[OH-]>>N#Cc1cc2c(cc1Oc1ccc(C(=O)Nc3nnc(-c4ccccc4)s3)cc1)OCCC2C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCc1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)N[C@@H]4CNC[C@H]4O)c(C)[nH]c23)c1.COCC(=O)Cl.Cl>>CCc1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)N[C@@H]4CN(C(=O)COC)C[C@H]4O)c(C)[nH]c23)c1",
        "output": "125"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCC1CCCN1C(=O)c1ccc(C(=O)NC(CC(N)=O)c2nc3cc(Cl)ccc3[nH]2)cc1Cl.CO.ClCCl.ClCl.O=C(O)C(F)(F)F>>NCC1CCCN1C(=O)c1ccc(C(=O)NC(CC(N)=O)c2nc3cc(Cl)ccc3[nH]2)cc1Cl",
        "output": "538"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)CCOc1ccc(S(N)(=O)=O)cc1.Cc1nn(-c2ccc(CCNC(=O)Oc3ccccc3)cc2)c(C)c1-c1ccccc1>>Cc1nn(-c2ccc(CCNC(=O)NS(=O)(=O)c3ccc(OCCN(C)C)cc3)cc2)c(C)c1-c1ccccc1",
        "output": "690"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cc2cc(Oc3ccc(-c4cc(C(F)(F)F)c(C#N)c(=O)n4Cc4ccc(C)cc4C)cc3)ccc2[nH]1.[Li+].[OH-]>>Cc1ccc(Cn2c(-c3ccc(Oc4ccc5[nH]c(C(=O)O)cc5c4)cc3)cc(C(F)(F)F)c(C#N)c2=O)c(C)c1",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCCC.CCN(CC)CC.CCOC(C)=O.COc1ccc2c(c1)C(CCN)=C(c1ccccc1)C2.Cl.ClC(Cl)Cl.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COc1ccc2c(c1)C(CCNC(=O)C(F)(F)F)=C(c1ccccc1)C2",
        "output": "316"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCCc1ccc2nonc2c1>>CS(=O)(=O)OCCc1ccc2nonc2c1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COC1CCN(S(=O)(=O)c2ccc(CNC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)cc2)CC1.ClCCl>>O=C(NCc1ccc(S(=O)(=O)N2CCC(O)CC2)cc1)c1cncc2c1cnn2-c1ccc(F)cc1",
        "output": "423"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOc1ncc(Cc2cnc(N)nc2)cc1Br.COc1ncc(CO)cc1-c1ccc(F)cc1.O=C([O-])O.O=C([O-])[O-].OB(O)c1ccc(F)c(Cl)c1.[Na+].[Na+].[Na+]>>CCOc1ncc(Cc2cnc(N)nc2)cc1-c1ccc(F)c(Cl)c1",
        "output": "833"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(O)COc1ccc2c(Oc3ccc([N+](=O)[O-])cc3F)ccnc2c1.O.O=CO[K].[Pd]>>CC(C)(O)COc1ccc2c(Oc3ccc(N)cc3F)ccnc2c1",
        "output": "335"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)N.CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(C(C)(C)C=O)cn1>>CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(C(C)(C)CNC(C)C)cn1",
        "output": "426"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCCCCCCCCCCCCOc1cc(OCCCCCCc2cccc(O)c2O)cc(C(=O)O)c1.CI.CN(C)C=O.O=C([O-])O.[Na+]>>CCCCCCCCCCCCCCCCCCOc1cc(OCCCCCCc2cccc(O)c2O)cc(C(=O)OC)c1",
        "output": "415"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.O=c1c(CCC(O)c2ccncc2)cc2cccnc2n1-c1cccc([N+](=O)[O-])c1.c1ccncc1>>CC(=O)OC(CCc1cc2cccnc2n(-c2cccc([N+](=O)[O-])c2)c1=O)c1ccncc1",
        "output": "254"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CCN(CC)CC.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.Oc1ccccc1>>CC(=O)Oc1ccccc1",
        "output": "108"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCN(CC)CC.CN(Cc1ccccn1)C(=O)OC(C)(C)C.Cl>>CNCc1ccccn1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)O.ClCCl.NCc1ccc(CN(Cc2ccc(F)cc2)S(=O)(=O)c2cc(Cl)cc(Cl)c2O)cc1.O=Cc1ccc(F)cc1.[BH4-].[Na+]>>O=S(=O)(c1cc(Cl)cc(Cl)c1O)N(Cc1ccc(F)cc1)Cc1ccc(CNCc2ccc(F)cc2)cc1",
        "output": "683"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(=O)CC1.Fc1ccc(Br)c(F)c1.[Cl-].[NH4+]>>CC(C)(C)OC(=O)N1CCC(O)(c2ccc(F)cc2F)CC1",
        "output": "321"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)n1ncc(O)c(Cl)c1=O.CCOCCOc1ccc(CBr)cc1.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCOCCOc1ccc(COc2cnn(C(C)(C)C)c(=O)c2Cl)cc1",
        "output": "623"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N1CCC(CC(=O)Nc2cccc(Br)n2)CC1.OB(O)c1cc(F)cc(F)c1>>CC(=O)N1CCC(CC(=O)Nc2cccc(-c3cc(F)cc(F)c3)n2)CC1",
        "output": "869"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOP(=O)(Cl)OCC.CNC.Cl.O=C(Cc1ccccc1C(=O)O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1>>CN(C)C(=O)c1ccccc1CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CN.Cc1ccc(S(=O)(=O)OC[C@H]2COc3ccc(S(C)(=O)=O)cc3O2)cc1.Cl>>CNC[C@H]1COc2ccc(S(C)(=O)=O)cc2O1",
        "output": "853"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.O.O=C(O)CCBr.OCc1ccccc1.c1ccccc1>>O=C(CCBr)OCc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)OB(c2ccc(N)cc2)OC1(C)C.CCO.Cc1ccccc1.Clc1nc(N2C3CCC2COC3)c(Cl)c(N2C3CCC2COC3)n1.O.O=C([O-])[O-].[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Nc1ccc(-c2nc(N3C4CCC3COC4)c(Cl)c(N3C4CCC3COC4)n2)cc1",
        "output": "974"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.CSc1ccccc1Cn1c(C)cc(OCc2ccccc2CNC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(Cl)c(O[Si](C)(C)C(C)(C)C)c2)c(Cl)c1=O.Cl.[F-].[K+]>>CSc1ccccc1Cn1c(C)cc(OCc2ccccc2CNC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(Cl)c(O)c2)c(Cl)c1=O",
        "output": "754"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CC(C)(C)O.CCOC(C)=O.NCCO.O.O=Cc1ccc(Br)cc1.[Cu]I.[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(O)C#Cc1ccc(C=O)cc1",
        "output": "659"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NCCCO.O=C(O)c1ccc2c(c1)OCO2>>O=C(NCCCO)c1ccc2c(c1)OCO2",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.Cl.ClCCl.NCc1ccc(C(F)(F)F)nc1.O=C(O)CN1CCC(c2ccccc2)(c2ccccc2)C1=O>>O=C(CN1CCC(c2ccccc2)(c2ccccc2)C1=O)NCc1ccc(C(F)(F)F)nc1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCC(C(=O)O)CC1.Cc1cnc(NC(=O)c2ccc(Oc3ccnc4[nH]nc(C5CCCNC5)c34)cc2)s1.Cl.O=C([O-])O.On1nnc2ccccc21.[Na+]>>Cc1cnc(NC(=O)c2ccc(Oc3ccnc4[nH]nc(C5CCCN(C(=O)C6CCN(C)CC6)C5)c34)cc2)s1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1=CCCCC1.CCN(CC)C(=O)c1nc(-c2ccc(OC)nc2)c(-c2ccc(OCc3ccccc3)cc2)o1.CCO.[OH-].[OH-].[Pd+2]>>CCN(CC)C(=O)c1nc(-c2ccc(OC)nc2)c(-c2ccc(O)cc2)o1",
        "output": "23"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)C(NC(=O)OCc1ccccc1)C(=O)N1CCC2C1C(Oc1ccc(F)c(F)c1)CN2C1CCOCC1.CO>>CC(C)(C)C(N)C(=O)N1CCC2C1C(Oc1ccc(F)c(F)c1)CN2C1CCOCC1",
        "output": "128"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CN.Nc1ccc(I)cc1C(=O)O>>CNC(=O)c1cc(I)ccc1N",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)c1ccc(S(=O)(=O)Cl)cc1.CCN(CC)CC.COC(=O)c1cnc(N2CCNCC2)s1.ClCCl.O>>COC(=O)c1cnc(N2CCN(S(=O)(=O)c3ccc(C(C)=O)cc3)CC2)s1",
        "output": "99"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1cc(O)cc(C)c1C=O.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.OCCF>>Cc1cc(OCCF)cc(C)c1C=O",
        "output": "478"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)[C@@H]1C[C@H]1C(=O)Nc1ccc2c(c1)CC(N)C2.CCc1[nH]c(C(=O)O)nc1Cl.O=S(Cl)Cl.c1ccncc1>>CCOC(=O)[C@@H]1C[C@H]1C(=O)Nc1ccc2c(c1)CC(NC(=O)c1nc(Cl)c(CC)[nH]1)C2",
        "output": "951"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(C(=O)c2c(Cc3ccc(Br)cc3)sc(C)c2C)cc1C1CCCC1.ClCCl>>Cc1sc(Cc2ccc(Br)cc2)c(C(=O)c2ccc(O)c(C3CCCC3)c2)c1C",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COCO[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1COC(C)=O.[Na+].[OH-]>>COCO[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1CO",
        "output": "225"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "NC(c1ccccc1)c1cccs1.O=C(O)CNC(=O)c1ccc(F)cc1>>O=C(CNC(=O)c1ccc(F)cc1)NC(c1ccccc1)c1cccs1",
        "output": "599"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Nc1ccc(C(=O)O)cc1.O=C(Cl)C1CCCCCC1>>O=C(O)c1ccc(NC(=O)C2CCCCCC2)cc1",
        "output": "9"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CI.COCc1ncc(Br)c(C(=O)O)n1.O=C([O-])[O-].[Cs+].[Cs+]>>COCc1ncc(Br)c(C(=O)OC)n1",
        "output": "415"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.C[C@@H]1[C@H](c2ccccc2)C[C@H](N)c2nnc(C3(C(F)(F)F)CC3)n21.Cl.O.O=C(O)c1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21.On1nnc2cccnc21>>C[C@@H]1[C@H](c2ccccc2)C[C@H](NC(=O)c2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)c2nnc(C3(C(F)(F)F)CC3)n21",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)COc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12.CC[NH+](CC)CC.CNC>>CC(COc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)N(C)C",
        "output": "187"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1cc(-c2cccc3c2CCCN3C(=O)CCCOc2cccc(C)c2C)ccn1.COC(=O)c1cccc(Cn2cc(Br)cn2)c1>>O=C(O)c1cccc(Cn2cc(Br)cn2)c1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)c1cc(OC)cc2c1CC(c1ccc(OC)cc1)C1CCCC21.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>COc1ccc(C2Cc3c(CO)cc(OC)cc3C3CCCC23)cc1",
        "output": "444"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CSc1nc2[nH]c(-c3ccnc(/C=C/c4ccccc4)c3)cc2c(=O)[nH]1.NC(CO)CO>>O=c1[nH]c(NC(CO)CO)nc2[nH]c(-c3ccnc(/C=C/c4ccccc4)c3)cc12",
        "output": "101"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CNCC(O)CO.COc1ccccc1-c1ccc(C(=O)N2Cc3ccc(C(=O)O)n3Cc3ccccc32)cc1C.Cl.O.On1nnc2ccccc21>>COc1ccccc1-c1ccc(C(=O)N2Cc3ccc(C(=O)N(C)CC(O)CO)n3Cc3ccccc32)cc1C",
        "output": "605"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc(C(=O)O)ccc1N.NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1>>COc1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)ccc1N",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.ClCCl.O=C(Cl)CCl.O=C([O-])O.[Na+].c1ccc2c(c1)CC(Nc1ncc3c(n1)CCNC3)C2>>O=C(CCl)N1CCc2nc(NC3Cc4ccccc4C3)ncc2C1",
        "output": "125"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(CCc4ccccc4)c3)c3cc(-c4ccc(N5CCNCC5)nc4)cnc32)cc1.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4ccc(C5CCNCC5)cc4)cnc32)cc1.Cl.O.[Li+].[OH-]>>c1ccc(CCn2cc(-c3c[nH]c4ncc(-c5ccc(N6CCNCC6)nc5)cc34)cn2)cc1",
        "output": "949"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(C)=O.CO.COC(=O)c1ccc(C#CCc2ccc3c(c2)C(C)(C)CCC3(C)C)cc1O.Cc1ccccc1.Cl.O.[H-]>>CC1(C)CCC(C)(C)c2cc(CC#Cc3ccc(CO)c(O)c3)ccc21",
        "output": "444"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.O=C([O-])[O-].O=Cc1ccc(F)cc1.Oc1c(F)cccc1F.[K+].[K+]>>O=Cc1ccc(Oc2c(F)cccc2F)cc1",
        "output": "564"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)[C@@H](Cc1ccccc1)NCc1ccc(-c2onc(C)c2NC(=O)O[C@H](C)c2ccccc2)cc1.Cl.[Li+].[OH-]>>Cc1noc(-c2ccc(CN[C@H](Cc3ccccc3)C(=O)O)cc2)c1NC(=O)O[C@H](C)c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)O.CCOC(=O)C1CCN(CCOc2ccc(OC(=O)N(C)c3cccc(O)c3)cc2)CC1.Cl.ClC(Cl)Cl.[K+].[OH-]>>CN(C(=O)Oc1ccc(OCCN2CCC(C(=O)O)CC2)cc1)c1cccc(O)c1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CCCCOC(=O)N[C@H](CC#N)C(=O)O.CN(C)c1ccncc1.CO>>CCCCOC(=O)N[C@H](CC#N)C(=O)OC",
        "output": "195"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.CCN(CC)CC.CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)Nc4cccc(Br)n4)cc3)c(Cl)cc21.Cl[Pd]Cl.OB(O)c1ccc(F)cc1F.[Cs+].[F-].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)Nc4cccc(-c5ccc(F)cc5F)n4)cc3)c(Cl)cc21",
        "output": "869"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)[Si](Cl)(C(C)C)C(C)C.CCOCC.CN(C)C=O.Cc1cc(O)cc(C=O)c1.O.c1c[nH]cn1>>Cc1cc(C=O)cc(O[Si](C(C)C)(C(C)C)C(C)C)c1",
        "output": "746"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCc1nc2c(c(C)c(C)n3nnnc23)n1CC(C)(C)N.CCN(CC)CC.ClCCl.O.O=C(Cl)c1ccccc1>>CCCc1nc2c(c(C)c(C)n3nnnc23)n1CC(C)(C)NC(=O)c1ccccc1",
        "output": "271"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Cl.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.NCCOc1ccc2c(ccn2S(=O)(=O)c2ccccc2)c1>>CC(=O)NCCOc1ccc2c(ccn2S(=O)(=O)c2ccccc2)c1",
        "output": "45"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)C[C@@H]1CC=CCCC(=O)N[C@H](c2ccccc2)COC1=O.CCN(C(C)C)C(C)C.CN(C)c1ccncc1.ClCCCl.ClCCl.NCc1ccc(Cl)cc1.O=C(O)C(F)(F)F.O=C(O)C[C@@H]1CC=CCCC(=O)N[C@H](c2ccccc2)COC1=O.On1nnc2ccccc21>>O=C(C[C@@H]1CC=CCCC(=O)N[C@H](c2ccccc2)COC1=O)NCc1ccc(Cl)cc1",
        "output": "599"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CC2CC(Nc3nc(Nc4cc(C5CC5)[nH]n4)ncc3Cl)CC2C1.CCOC(C)=O.Cl.ClCCl>>Clc1cnc(Nc2cc(C3CC3)[nH]n2)nc1NC1CC2CNCC2C1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc2c(c1)N(CCN1CCC(N)CC1)C(=O)OC2.Cn1c(=O)c2ccc(F)cc2n(CCN2CCC(NC(=O)OC(C)(C)C)CC2)c1=O.O=C(O)C(F)(F)F>>Cn1c(=O)c2ccc(F)cc2n(CCN2CCC(N)CC2)c1=O",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=O.O=CO.c1ccc(CON=C(c2ccccc2)C2CCCN2)cc1>>CN1CCCC1C(=NOCc1ccccc1)c1ccccc1",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCN.CCc1ccc(Oc2ccc(S(=O)(=O)Cl)cc2F)c(OCc2ccccc2)c1.N>>CCCNS(=O)(=O)c1ccc(Oc2ccc(CC)cc2OCc2ccccc2)c(F)c1",
        "output": "43"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)CC(N)CC(C)(C)N1.CN(C)C=O.CN(C)[C+](On1nnc2ccccc21)N(C)C.CN1CCOCC1.Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)O.F[B-](F)(F)F>>Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC1CC(C)(C)NC(C)(C)C1",
        "output": "697"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CN(C)C1(c2ccccc2)CCC(CN)CC1.O=C(NCCCc1ccccc1)Oc1ccccc1>>CN(C)C1(c2ccccc2)CCC(CNC(=O)NCCCc2ccccc2)CC1",
        "output": "488"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClC(Cl)Cl.N#CC(C[C@@H](O)COCc1ccccc1)c1ccccc1.c1ccncc1>>Cc1ccc(S(=O)(=O)O[C@@H](COCc2ccccc2)CC(C#N)c2ccccc2)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)c1ccccc1Sc1ccc(C(=O)CBr)c(Cl)c1Cl.N.NC(=S)N1CCCCC1>>CC(C)c1ccccc1Sc1ccc(-c2csc(N3CCCCC3)n2)c(Cl)c1Cl",
        "output": "716"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CC(C)(C)c1nc2cc(S(=O)(=O)Cl)ccc2n1CC1CCOCC1.CN(C)c1ccncc1.NC1CC1>>CC(C)(C)c1nc2cc(S(=O)(=O)NC3CC3)ccc2n1CC1CCOCC1",
        "output": "43"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCCc1ccccc1.CN(C)C=O.Cc1cc(C(O)(C(C)c2ccc(O)cc2Cl)C(F)(F)F)ccn1.[H-].[Na+]>>Cc1cc(C(O)(C(C)c2ccc(OCCc3ccccc3)cc2Cl)C(F)(F)F)ccn1",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cnn(Cc2ccc(OC)cc2)c1Cc1ccccc1F.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1ccc(Cn2ncc(CO)c2Cc2ccccc2F)cc1",
        "output": "471"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCOCCCOCc1ccccc1.CO.[C].[Pd]>>CC(C)(C)OC(=O)NCCOCCCO",
        "output": "178"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1cc(-c2ccnn2-c2ccc(C#N)cc2)c(C)n(-c2cccc(C(F)(F)F)c2)c1=O.CN(C)CCCCN>>Cc1c(-c2ccnn2-c2ccc(C#N)cc2)cc(C(=O)NCCCCN(C)C)c(=O)n1-c1cccc(C(F)(F)F)c1",
        "output": "498"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNCC1.CC(=O)O.CCC(CC)(c1ccc(C=O)c(C)c1)c1ccc(OCC(O)C(C)(C)C)c(C)c1.Cc1ccccc1.O=C1CSC(=O)N1>>CCC(CC)(c1ccc(C=C2SC(=O)NC2=O)c(C)c1)c1ccc(OCC(O)C(C)(C)C)c(C)c1",
        "output": "761"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1=COCCC1.C1CCOC1.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.OCCCCO.c1cc[nH+]cc1>>OCCCCOC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)O.CS(C)=O.N#Cc1ccc(OCCCN2CCC(CCCO)CC2)cc1.NO.O>>NC(=NO)c1ccc(OCCCN2CCC(CCCO)CC2)cc1",
        "output": "400"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](OCCNC(=O)OCc1ccccc1)(c1ccccc1)c1ccccc1.CO.[OH-].[OH-].[Pd+2]>>CC(C)(C)[Si](OCCN)(c1ccccc1)c1ccccc1",
        "output": "574"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.O=C(O)Cc1cccc(F)c1F>>OCCc1cccc(F)c1F",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)c1ccc(C(=O)O)cc1.CCN=C=NCCCN(C)C.Nc1ccc(F)cc1.c1ccncc1>>CCN(CC)c1ccc(C(=O)Nc2ccc(F)cc2)cc1",
        "output": "50"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CNC.O=Cc1cc2c(nc1-c1ccccc1)N(c1ccnc(NCCc3ccccc3)n1)CCC2>>CN(C)Cc1cc2c(nc1-c1ccccc1)N(c1ccnc(NCCc3ccccc3)n1)CCC2",
        "output": "757"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)[C@H]1CCNC1.O=C(O)c1cc2ccc(Cl)cc2[nH]1>>CN(C)[C@H]1CCN(C(=O)c2cc3ccc(Cl)cc3[nH]2)C1",
        "output": "605"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)N1c2ccccc2C(Nc2ccc(CO)cc2)CC1C.CI.[H-].[Na+]>>COCc1ccc(NC2CC(C)N(C(C)=O)c3ccccc32)cc1",
        "output": "140"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "B.C1CCOC1.C1CCOC1.CO.O=C1COc2cc([N+](=O)[O-])ccc2N1>>O=[N+]([O-])c1ccc2c(c1)OCCN2",
        "output": "363"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1CCNCC1.COC(=O)CC/C=C(\\C)CC/C=C(\\C)CC/C=C(\\C)CCC=C(C)C>>CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CCC(=O)N1CCN(C)CC1",
        "output": "227"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCC(Cc1ccc(OCCN=[N+]=[N-])cc1)C(=O)OCC.[Pd]>>CCCCC(Cc1ccc(OCCN)cc1)C(=O)OCC",
        "output": "89"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCBr.CCI.COc1cc(C=O)ccc1O.O=Cc1ccc(O)cc1>>CCOc1ccc(C=O)cc1OC",
        "output": "198"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCOC(=O)CCCOc1ccc(C(=N)N)cc1.Cl.I>>N=C(N)c1ccc(OCCCC(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCc1nc(C(C)(C)O)c(-c2nnn[nH]2)n1Cc1ccc(-c2ccccc2C(=O)C(=O)OC)cc1.O.[Li+].[OH-]>>CCCc1nc(C(C)(C)O)c(-c2nnn[nH]2)n1Cc1ccc(-c2ccccc2C(=O)C(=O)O)cc1",
        "output": "506"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.Cl.N#CC1CCC2(CC1)OCCO2>>N#CC1CCC(=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(c2cccc([N+](=O)[O-])c2)Cn2ccnc2C(N)=N1.CCO.[H][H].[Pd]>>CC1(c2cccc(N)c2)Cn2ccnc2C(N)=N1",
        "output": "71"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(C)=O.Cc1nn(-c2ncccc2C#N)cc1CN1CCC2(CC1)OCCc1cc(F)sc12.O.O=C([O-])[O-].OO.[K+].[K+]>>Cc1nn(-c2ncccc2C(N)=O)cc1CN1CCC2(CC1)OCCc1cc(F)sc12",
        "output": "677"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#Cc1ccc(Br)cc1.CCN(CC)CC.CN(C)C=O.Cl[Pd]Cl.N#Cc1ccncc1I.[Cu]I.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1ccncc1C#Cc1ccc(Br)cc1",
        "output": "819"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)CC(C)(N)CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.Cc1cc(OCCC(C(F)(F)F)C(F)(F)F)c2nc(C)c(C(=O)O)n2c1.F[P-](F)(F)(F)(F)F>>Cc1cc(OCCC(C(F)(F)F)C(F)(F)F)c2nc(C)c(C(=O)NCC(C)(N)CC(C)C)n2c1",
        "output": "697"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(Cl)Cl.COC(=O)c1nn(C(C)C)c2cc(Cl)ncc12.C[Sn+](C)C.Cl.[OH-]>>CC(C)n1nc(C(=O)O)c2cnc(Cl)cc21",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.COc1ccccc1OCCN(Cc1ccccc1)CC(O)COc1cccc2[nH]c3ccccc3c12.NCc1ccccc1.[Cl-].[Cl-].[Pd].[Zn+2].c1ccc2c(c1)[nH]c1cccc(OCC3CO3)c12>>COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12",
        "output": "84"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1c(I)nn2c1CN(C(=O)NC(C)(C)C)CC2.O.[Li+].[OH-]>>CC(C)(C)NC(=O)N1CCn2nc(I)c(C(=O)O)c2C1",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1ccccc1CC#N.Cl.[Na+].[OH-]>>N#CCc1ccccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClC(Cl)Cl.N#Cc1cc(Br)c(O)c(Br)c1.O=C(Cl)OCCl.c1ccncc1>>N#Cc1cc(Br)c(OC(=O)OCCl)c(Br)c1",
        "output": "261"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.COc1cc2c(C(=O)O)c(C(C)C)n(Cc3ccccc3)c2cn1.ClCCCl.ClCCl.NCc1ccc(F)c(F)c1>>COc1cc2c(C(=O)NCc3ccc(F)c(F)c3)c(C(C)C)n(Cc3ccccc3)c2cn1",
        "output": "790"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(O)C1C(=O)C2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(Sc3ccccc3)CC21.COc1ccccc1.O=C(O)C(F)(F)F>>CC(O)C1C(=O)C2C(C(=O)O)=C(Sc3ccccc3)CC21",
        "output": "228"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCC(C(=O)O)n1cc(C)c(-c2ccccc2)n1.CN.Cc1cn(C(C)C(=O)O)nc1-c1ccccc1.N>>CCCC(C(=O)NC)n1cc(C)c(-c2ccccc2)n1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.OCc1ccc(OC2C=CCCC2)cc1.c1cc[nH+]cc1>>O=Cc1ccc(OC2C=CCCC2)cc1",
        "output": "179"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCn1nc(-c2ccc(O)cc2)c2ncccc21.CN(C)C=O.C[Si](C)(C)CCOCn1c(Cl)nc2ccccc21.O.[H-].[Na+]>>CCn1nc(-c2ccc(Oc3nc4ccccc4n3COCC[Si](C)(C)C)cc2)c2ncccc21",
        "output": "542"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCN1C(=O)C(CCO)Oc2cc([N+](=O)[O-])ccc21.CCOC(C)=O.CS(=O)(=O)Cl>>CCN1C(=O)C(CCOS(C)(=O)=O)Oc2cc([N+](=O)[O-])ccc21",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccccc1.Nc1ccc(Cl)cc1Cl.O=S(Cl)Cl.[N-]=[N+]=Nc1cc(Cl)ccc1C(=O)O.c1ccncc1>>[N-]=[N+]=Nc1cc(Cl)ccc1C(=O)Nc1ccc(Cl)cc1Cl",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.Cc1ccccc1.O=C(Cl)c1ccccc1.Oc1ccccc1-c1ccccc1>>O=C(Oc1ccccc1-c1ccccc1)c1ccccc1",
        "output": "482"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cc2ccc(C#N)cc2cc1C#N.O.[Al+3].[Cl-].[Cl-].[Cl-].c1ccccc1>>N#Cc1ccc2cc(O)c(C#N)cc2c1",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1CN(CCC=C2c3cc(O)ccc3OCc3ncccc32)CCC1(O)c1ccc(Cl)cc1.CN(C)C=O.COC(=O)CBr.[H-].[Na+]>>COC(=O)COc1ccc2c(c1)C(=CCCN1CCC(O)(c3ccc(Cl)cc3)C(C)C1)c1cccnc1CO2",
        "output": "557"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N1CCC(N2C(=O)c3ccccc3C2=O)C(NC(=O)OC(C)(C)C)C1.CCO.CCOC(C)=O.NN.O>>CC(=O)N1CCC(N)C(NC(=O)OC(C)(C)C)C1",
        "output": "242"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCN.ClCCl.O=C(Cl)CCl.O=C([O-])[O-].[K+].[K+]>>CCCCNC(=O)CCl",
        "output": "45"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(O)C(c1ccc(CN2N=C(c3ccccc3)OCC2=O)cc1)C1CCCC1.O=S(Cl)Cl>>O=C(Cl)C(c1ccc(CN2N=C(c3ccccc3)OCC2=O)cc1)C1CCCC1",
        "output": "53"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CCN(CCN)CC1.Fc1ccc2nc3cc(Cl)ccc3c(Cl)c2c1>>CN1CCN(CCNc2c3ccc(Cl)cc3nc3ccc(F)cc23)CC1",
        "output": "78"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCCN.O=S(=O)(Cl)c1cccs1>>COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1cccs1",
        "output": "600"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C(O)c1cc(Cl)ccc1O>>O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(Cl)ccc1O",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCc2c(/C=C/[N+](=O)[O-])c3ccccc3n2CC1.CO.Cl>>O=[N+]([O-])/C=C/c1c2n(c3ccccc13)CCNCC2",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.COc1ccccc1N=C=O.ClC(Cl)Cl>>COc1ccccc1NC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1",
        "output": "912"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)NC(C)C.CN(C)C=O.Fc1ccc(Br)c(F)c1F.[Cl-].[Li]CCCC.[NH4+]>>O=Cc1cc(Br)c(F)c(F)c1F",
        "output": "239"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1nc2cc(C#N)ccc2n1[C@H]1CC[C@@H](N)CC1.O=CC1Cc2ccc(Cl)cc2C1>>Cc1nc2cc(C#N)ccc2n1[C@H]1CC[C@@H](NCC2Cc3ccc(Cl)cc3C2)CC1",
        "output": "426"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)n1ncc2cc([N+](=O)[O-])ccc21.CCOC(C)=O.[Pd]>>CC(C)(C)OC(=O)n1ncc2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.Cl.NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1.c1n[nH]c2c1CNC2>>NS(=O)(=O)Cc1cccc(Nc2ncnc(N3Cc4cn[nH]c4C3)n2)c1",
        "output": "214"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCc1nc2c(C)ccc(OCCCCCn3cnc4ccccc43)c2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCCCc1nc2c(C)ccc(OCCCCCn3cnc4ccccc43)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCCCCOc1ccc(Br)cc1.CCOC(C)=O.CO.C[O-].O.[Na+]>>COCCCCOc1ccc(Br)cc1",
        "output": "95"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.Clc1cc(Cl)ncn1.O.O=[N+]([O-])c1ccc(O)cc1.[Na+].[OH-]>>O=[N+]([O-])c1ccc(Oc2cc(Cl)ncn2)cc1",
        "output": "668"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.Cl.ClCCl.O=C1CCC(c2ccccc2)(c2ccccc2)[C@@H]2CNC[C@H]12>>CC(C)(C)OC(=O)N1C[C@@H]2C(=O)CCC(c3ccccc3)(c3ccccc3)[C@@H]2C1",
        "output": "694"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(C)=O.Cc1cc(C)c(CN)c(=O)[nH]1.Cc1nn(C(C)C)c2nc(Br)cc(C(=O)O)c12.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>Cc1cc(C)c(CNC(=O)c2cc(Br)nc3c2c(C)nn3C(C)C)c(=O)[nH]1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cccc(F)c1O.Clc1ncc(Cl)c(Cl)n1>>COc1cccc(F)c1Oc1nc(Cl)ncc1Cl",
        "output": "890"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C[C@@H]1CCc2cc(OCCCBr)ccc21.CN(C)C=O.Nc1ccccc1.[Cl-].[H-].[NH4+].[Na+]>>CCOC(=O)C[C@@H]1CCc2cc(OCCCNc3ccccc3)ccc21",
        "output": "273"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccccc1CN(c1ccc(C#N)c(Cl)c1)[C@H]1CCNC1.O=Cc1ccc(C(=O)O)cc1>>Cc1ccccc1CN(c1ccc(C#N)c(Cl)c1)[C@H]1CCN(Cc2ccc(C(=O)O)cc2)C1",
        "output": "567"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)OC(C)C.CCCN(CCC)C1CCc2cccc(OCCN)c2C1.CCO.CS(=O)(=O)Cl.Cc1ccccc1.O=C([O-])[O-].[K+].[K+]>>CCCN(CCC)C1CCc2cccc(OCCNS(C)(=O)=O)c2C1",
        "output": "493"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCC(C(=O)OC)c1ccccc1Br.CCO.Cc1ccccc1.O.O=C([O-])[O-].OB(O)c1ccccc1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCC(C(=O)OC)c1ccccc1-c1ccccc1",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN(C)C=O.COC1c2ccccc2C(=O)N1CCBr.Fc1ccc2[nH]cc(CC3CCNCC3)c2c1.O=C([O-])O.[Na+]>>COC1c2ccccc2C(=O)N1CCN1CCC(Cc2c[nH]c3ccc(F)cc23)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC[Si](Cl)(CC)CC.O=C([O-])O.Oc1c(Cl)cccc1Cl.[Na+].c1ccncc1>>CC[Si](CC)(CC)Oc1c(Cl)cccc1Cl",
        "output": "746"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)c1ccc(F)cc1.CS(C)=O.NC1CCNCC1.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)c1ccc(N2CCC(N)CC2)cc1",
        "output": "773"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCI.O=C(OCc1ccccc1)N1CCNCC1>>CCCCN1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "184"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCOC(=O)C1CCC(O)CC1.ClCCl.O.c1c[nH]cn1>>CCOC(=O)C1CCC(O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CC1",
        "output": "602"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Cl.CCN(CC)CC.CN[C@H]1CCN(C(C(=O)N(C)Cc2c(OC)c(C#N)cc3ccccc23)c2ccc(F)cc2)C1.ClCCl.O=C([O-])O.[Na+]>>COc1c(C#N)cc2ccccc2c1CN(C)C(=O)C(c1ccc(F)cc1)N1CC[C@H](N(C)C(C)=O)C1",
        "output": "125"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Clc1cc(N2CCNCC2)c2ncccc2c1.Clc1ccc2occ(CCI)c2c1>>Clc1cc(N2CCN(CCc3coc4ccc(Cl)cc34)CC2)c2ncccc2c1",
        "output": "184"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)CSc1nc(Cl)cc(Cl)n1.Clc1ccc(N2CCNCC2)cc1.O=C([O-])[O-].[Na+].[Na+]>>CCOC(=O)CSc1nc(Cl)cc(N2CCN(c3ccc(Cl)cc3)CC2)n1",
        "output": "162"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(OCC)[C@H](C)N(Cc1cccc2cccnc12)C(=O)[C@H](C)N.CN(CC(=O)O)NC(=O)NCc1cccc2ccccc12>>CCOC(OCC)[C@H](C)N(Cc1cccc2cccnc12)C(=O)[C@H](C)NC(=O)CN(C)NC(=O)NCc1cccc2ccccc12",
        "output": "133"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.O=C(c1nsc2cc(O)ccc12)N1CCN2CCC1CC2.OCC1CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(c1nsc2cc(OCC3CC3)ccc12)N1CCN2CCC1CC2",
        "output": "478"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)Cc1cc(-c2ccc(C)cc2)n(-c2ccc(S(N)(=O)=O)cc2)n1.[Na+].[OH-]>>Cc1ccc(-c2cc(CC(=O)O)nn2-c2ccc(S(N)(=O)=O)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)C[AlH]CC(C)C.COc1ccc(C2CCc3ccccc3C2=O)cc1>>COc1ccc(C2CCc3ccccc3C2O)cc1",
        "output": "24"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)Cc1ccccc1OCc1cc(OCCc2nc(-c3ccccc3)sc2C)no1.Cl.O.[Na+].[OH-]>>Cc1sc(-c2ccccc2)nc1CCOc1cc(COc2ccccc2CC(=O)O)on1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1nc(-n2ccc(OCc3ccc(C(F)(F)F)o3)cc2=O)sc1C(=O)O.NCc1cccnc1>>Cc1nc(-n2ccc(OCc3ccc(C(F)(F)F)o3)cc2=O)sc1C(=O)NCc1cccnc1",
        "output": "534"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.Cc1cc(C(N)=O)ncc1C(SCCC1OCCO1)c1c(F)ccc(F)c1F.Cl.O>>Cc1cc(C(N)=O)ncc1C(SCCC=O)c1c(F)ccc(F)c1F",
        "output": "740"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "N#CCC(=O)O.Nc1ccc(OCc2cccc(F)c2)cc1>>N#CCC(=O)Nc1ccc(OCc2cccc(F)c2)cc1",
        "output": "646"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CCNC(=O)c1ccc(Cl)nn1.c1ccc(CC2CCNC2)cc1>>CC(C)CCNC(=O)c1ccc(N2CCC(Cc3ccccc3)C2)nn1",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.F[P-](F)(F)(F)(F)F.Nc1ccc(Cl)c(C(F)(F)F)c1.O.O=C(O)C1CSC(c2ccc(F)cc2)=N1>>O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)C1CSC(c2ccc(F)cc2)=N1",
        "output": "563"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.OCCC1CCNCC1>>CC(C)(C)OC(=O)N1CCC(CCO)CC1",
        "output": "694"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(=O)Nc1cncc(Br)c1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(=O)Nc1cncc(B2OC(C)(C)C(C)(C)O2)c1",
        "output": "943"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.O=C([O-])[O-].O=[N+]([O-])c1cccc(CBr)c1.Oc1ccc2ccccc2c1.[K+].[K+]>>O=[N+]([O-])c1cccc(COc2ccc3ccccc3c2)c1",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.NNc1cc(N2CCC(c3ccccc3)CC2)ncn1.O=C(O)CC1CC1.O=C([O-])[O-].O=S(Cl)Cl.[Na+].[Na+]>>O=C(CC1CC1)NNc1cc(N2CCC(c3ccccc3)CC2)ncn1",
        "output": "459"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C(O)c1ccccc1C(=O)c1ccc(F)cc1.O=S(Cl)Cl.c1ccccc1.c1ccncc1>>O=C(Cl)c1ccccc1C(=O)c1ccc(F)cc1",
        "output": "3"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(Br)cc(OCC)c2)c1CCC(=O)OCC.Cl[Pd]Cl.O=C([O-])[O-].OB(O)c1ccc(Cl)cc1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(OCC)cc(-c3ccc(Cl)cc3)c2)c1CCC(=O)OCC",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN.CO.COC(=O)c1cccc2nc(-c3ccc(CBr)cc3)oc12>>CNCc1ccc(-c2nc3cccc(C(=O)OC)c3o2)cc1",
        "output": "446"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)CCc1nc(-c2ccccc2)c(-c2ccccc2)n1COCC[Si](C)(C)C.[Na+].[OH-]>>C[Si](C)(C)CCOCn1c(CCC(=O)O)nc(-c2ccccc2)c1-c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)Nc1c(O)cccc1[N+](=O)[O-].CCOC(C)=O.[Pd]>>CC(C)(C)OC(=O)Nc1c(N)cccc1O",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)[C@H](C(=O)O)[C@@H]1/C=C\\C(=O)OCC(F)F.ClC(Cl)Cl.N#C[C@H](O)c1cccc(Oc2ccccc2)c1>>CC1(C)[C@H](C(=O)O[C@@H](C#N)c2cccc(Oc3ccccc3)c2)[C@@H]1/C=C\\C(=O)OCC(F)F",
        "output": "17"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.C[C@@H]1CC[C@H](N)C[C@H]1O.FC(F)(F)c1ccncc1CNc1ncc(C(F)(F)F)c(Cl)n1>>C[C@@H]1CC[C@H](Nc2nc(NCc3cnccc3C(F)(F)F)ncc2C(F)(F)F)C[C@H]1O",
        "output": "110"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)c1nc(C2CC2)cc(N2CCN(CCCCN)CC2)n1.CO.ClC(Cl)Cl.O=C(O)c1cn2ccccc2n1>>CC(C)(C)c1nc(C2CC2)cc(N2CCN(CCCCNC(=O)c3cn4ccccc4n3)CC2)n1",
        "output": "697"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CI.CO.C[Si](C)(C)[N-][Si](C)(C)C.Cc1ccccc1.O=[N+]([O-])c1ccc2c(c1)NCC2.[K+]>>CN1CCc2ccc([N+](=O)[O-])cc21",
        "output": "377"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCn1c(C)cc2c(OCc3ccccc3)cc(Cc3cnc(N)nc3N)cc21.CO.[Pd]>>CCn1c(C)cc2c(O)cc(Cc3cnc(N)nc3N)cc21",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CCCCCCCCC(C)Br.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].Oc1cccc(I)c1.[K+].[K+]>>CCOC(=O)CCCCCCCCC(C)Oc1cccc(I)c1",
        "output": "153"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C1COCCOCCOCCOCCOCCO1.CC(C)(C)[O-].CI.O=[N+]([O-])c1ccc2cc(-c3ccccc3)[nH]c2c1.[K+]>>Cn1c(-c2ccccc2)cc2ccc([N+](=O)[O-])cc21",
        "output": "191"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1noc(C)c1-c1ccc2c(O)c([N+](=O)[O-])cnc2c1.O=P(Cl)(Cl)Cl>>Cc1noc(C)c1-c1ccc2c(Cl)c([N+](=O)[O-])cnc2c1",
        "output": "177"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C(=O)CCl.Oc1cc(-c2ccnc3nc(C(F)(F)F)ccc23)ccc1F>>CN(C)C(=O)COc1cc(-c2ccnc3nc(C(F)(F)F)ccc23)ccc1F",
        "output": "458"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1cc(Br)cc(C(=O)OCC)n1.CN(C)C=O.COc1cc(OC)c(B(O)O)c(OC)c1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1cc(-c2c(OC)cc(OC)cc2OC)cc(C(=O)OCC)n1",
        "output": "872"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(C)=O.CCc1ccc2c(c1)C1CNCCC1N2.O=C(CCCCl)c1ccc(F)cc1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CCc1ccc2c(c1)C1CN(CCCC(=O)c3ccc(F)cc3)CCC1N2",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)n1c(-c2cc3ccccc3nc2Cl)cc2cc(CO)ccc21.ClCCl.O=[Mn]=O>>CC(C)(C)OC(=O)n1c(-c2cc3ccccc3nc2Cl)cc2cc(C=O)ccc21",
        "output": "179"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)/C=C/c1cnn(C)c1.[K+].[OH-]>>Cn1cc(/C=C/C(=O)O)cn1",
        "output": "58"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.COc1ccc([N+](=O)[O-])cc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl.[Na+].[OH-]>>COc1ccc(N)cc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl",
        "output": "202"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrP(Br)Br.ClCCl.O=[N+]([O-])c1ccc(CO)c(Cl)c1>>O=[N+]([O-])c1ccc(CBr)c(Cl)c1",
        "output": "300"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C1(Cc2cc(O)cc(Nc3ccnn3C(C)(C)C)n2)CCN(C(=O)OC(C)(C)C)CC1.ClC(Cl)Cl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)C1(Cc2cc(OS(=O)(=O)C(F)(F)F)cc(Nc3ccnn3C(C)(C)C)n2)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "731"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CNCCN1.CCO.COC(=O)c1cccc2nc(-c3cccc(CBr)c3)oc12>>COC(=O)c1cccc2nc(-c3cccc(CN4CCNCC4)c3)oc12",
        "output": "248"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(C)=O.Cl.O=C1CCCc2cc(F)cc(F)c21.[K+].[S-]c1ccccc1>>O=C1CCCc2cc(Sc3ccccc3)cc(F)c21",
        "output": "675"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(Cl)c2c1.O[C@H]1CCNC1>>Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(N3CC[C@H](O)C3)c2c1",
        "output": "398"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)c1ccc2c(c1)Oc1c(OC)cccc1N2C1CC2CCC(C1)N2C.COC(=O)c1ccc2c(c1)Oc1ccccc1N2C1CC2CCC(C1)N2C.O=C(O)C(F)(F)F.[Na+].[OH-]>>COc1cccc2c1Oc1cc(C(=O)O)ccc1N2C1CC2CCC(C1)N2C",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC=CCC[C@@H](O)C[C@@H]1OC(=O)[C@H]1CCCCCC.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cc1ccccc1C.O=CNCC(=O)O>>CC=CCC[C@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)CNC=O",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)Nc1ccc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)cc2)cc1.CC(C)(C)OC(=O)Nc1ccc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)cc2)cc1.CO.ClC(Cl)Cl>>N[C@H](Cc1ccccc1)C(=O)Nc1ccc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)cc2)cc1",
        "output": "431"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CN1CCC(Sc2ncc(C(O[Si](C)(C)C(C)(C)C)c3cccc(F)c3)n2C)CC1.Cn1c(C(O[Si](C)(C)C(C)(C)C)c2cccc(F)c2)cnc1Cl.[H-].[Na+]>>CN1CCC(Sc2ncc(C(O)c3cccc(F)c3)n2C)CC1",
        "output": "708"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1)[C@H]1Cc4ccc(C#N)c5c4[C@@]3(CCN1C)[C@H]2O5.CS(C)=O.O=C([O-])[O-].OO.[K+].[K+]>>CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1)[C@H]1Cc4ccc(C(N)=O)c5c4[C@@]3(CCN1C)[C@H]2O5",
        "output": "180"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=CC(=O)Cl.Nc1cccc(CCN2CCN(c3nsc4ccccc34)CC2)c1>>CC(C)=CC(=O)Nc1cccc(CCN2CCN(c3nsc4ccccc34)CC2)c1",
        "output": "10"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1CNCCC1(O)c1ccc(Br)cc1.COC(=O)Cl.Cl.ClCCl.c1ccncc1>>COC(=O)N1CCC(O)(c2ccc(Br)cc2)C(C)C1",
        "output": "219"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)O)c1.N#Cc1cnc(N2CCNCC2)s1>>CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)N2CCN(c3ncc(C#N)s3)CC2)c1",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)O.CN1C(=O)C(C)(F)CN(C2CCCCC2)c2nc(Cl)ncc21.COc1cc(C(=O)O)ccc1N.Cl>>COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CC(C)(F)C(=O)N2C",
        "output": "808"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C.CCO.CCOC(=O)Cc1nn(C/C=C/c2cccc(C(F)(F)F)c2F)c(=O)c2ccccc12.O.O=C([O-])O.[Na+]>>O=C(O)Cc1nn(C/C=C/c2cccc(C(F)(F)F)c2F)c(=O)c2ccccc12",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)CN1C(=O)C(N)Cc2ccccc21.CN(C)c1ccc(C(=O)O)cc1.On1nnc2ccccc21>>CN(C)c1ccc(C(=O)NC2Cc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)cc1",
        "output": "718"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(C)=O.Nc1nc(Cl)cc(Cl)n1.Oc1ccc2[nH]ccc2c1.[H-].[Na+]>>Nc1nc(Cl)cc(Oc2ccc3[nH]ccc3c2)n1",
        "output": "668"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOc1ccccc1N1CCNCC1.CCOc1nc2ccccc2nc1NC(=O)Oc1ccccc1>>CCOc1ccccc1N1CCN(C(=O)Nc2nc3ccccc3nc2OCC)CC1",
        "output": "525"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)N.Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)O)cn1.Cc1onc(-c2ccccc2)c1COc1ncc(C(=O)O)cc1Br>>Cc1onc(-c2ccccc2)c1COc1ncc(C(=O)NC(C)C)cc1Br",
        "output": "674"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC(=O)N1CCc2c(c(-c3ccc(Cl)cc3)nn2CCCCl)C1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.CO.Fc1ccccc1N1CCNCC1.O=C([O-])[O-].[I-].[K+].[K+]>>CC(=O)N1CCc2c(c(-c3ccc(Cl)cc3)nn2CCCN2CCN(c3ccccc3F)CC2)C1",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COCCc1nc2c(N)nc3ccccc3c2n1CCCCN.ClC(Cl)Cl.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>COCCc1nc2c(N)nc3ccccc3c2n1CCCCNS(=O)(=O)c1ccccc1[N+](=O)[O-]",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)CCNc1nc(OC)c([N+](=O)[O-])c(OC)n1.O=C[O-].[NH4+].[OH-].[OH-].[Pd+2]>>CCOC(=O)CCNc1nc(OC)c(N)c(OC)n1",
        "output": "660"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.ClC(Cl)Cl.Nc1c(F)cccc1F.c1ccncc1>>Nc1c(F)cc(Br)cc1F",
        "output": "98"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.COc1cc([N+](=O)[O-])cc(C(F)(F)F)c1.ClCCl>>O=[N+]([O-])c1cc(O)cc(C(F)(F)F)c1",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "NCCO.O=C(Cl)c1c([N+](=O)[O-])cc([N+](=O)[O-])cc1[N+](=O)[O-]>>O=C(NCCO)c1c([N+](=O)[O-])cc([N+](=O)[O-])cc1[N+](=O)[O-]",
        "output": "271"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.Cc1ccc(Nc2nc(Cl)ccc2[N+](=O)[O-])cc1.Cl.Cl[Sn]Cl.O.O.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(Nc2nc(Cl)ccc2N)cc1",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCc1ccccc1O.CI.CN(C)C=O.O.[H-].[Na+]>>CCCc1ccccc1OC",
        "output": "62"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.CSc1nc2c(C#N)c(Cl)ccc2[nH]1.O.O=S([O-])OO.[K+]>>CS(=O)(=O)c1nc2c(C#N)c(Cl)ccc2[nH]1",
        "output": "840"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc([C@H](Cc2c(Cl)c[n+]([O-])cc2Cl)OC(=O)c2ccc(CCO[Si](C)(C)C(C)(C)C)s2)cc1OC.c1ccncc1>>COc1ccc([C@H](Cc2c(Cl)c[n+]([O-])cc2Cl)OC(=O)c2ccc(CCO)s2)cc1OC",
        "output": "708"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)CC(=O)O.CN(C)c1ccncc1.COCOC1(c2ncc(-c3c(Cl)cnc4[nH]c(-c5ccc(N)cc5F)cc34)s2)CCC1.F[P-](F)(F)(F)(F)F>>COCOC1(c2ncc(-c3c(Cl)cnc4[nH]c(-c5ccc(NC(=O)CN(C)C)cc5F)cc34)s2)CCC1",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COc1ccc([N+](=O)[O-])c(Cl)n1.NC(CO)CO>>COc1ccc([N+](=O)[O-])c(NC(CO)CO)n1",
        "output": "70"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CSc1ccccc1-c1nc2cc(F)cc(F)c2c(Cl)c1C.ClC(Cl)Cl.ClCCl.O=S([O-])OO.[Al+3].[Al+3].[K+].[O-2].[O-2].[O-2]>>Cc1c(-c2ccccc2S(C)(=O)=O)nc2cc(F)cc(F)c2c1Cl",
        "output": "730"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Cn1ccc2cc(C(=O)Nc3ccc4c(-c5ccc([N+](=O)[O-])cc5)c[nH]c4c3)ccc21.[H][H].[OH-].[OH-].[Pd+2]>>Cn1ccc2cc(C(=O)Nc3ccc4c(-c5ccc(N)cc5)c[nH]c4c3)ccc21",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1cnc(N)c(O[C@H]2CNC[C@@H]2C)c1.Cl.O=C(O)Cc1ccc(OC(F)(F)F)cc1>>COC(=O)c1cnc(N)c(O[C@H]2CN(C(=O)Cc3ccc(OC(F)(F)F)cc3)C[C@@H]2C)c1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)s1.O=Cc1ccc(O)c(Cl)c1>>O=C(C=Cc1ccc(O)c(Cl)c1)c1ccc(-c2ccc(C(F)(F)F)cc2)s1",
        "output": "295"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1nc(CCOc2ccc([N+](=O)[O-])cn2)cs1.CCOC(C)=O.[H][H].[Pd]>>CC(C)(C)OC(=O)Nc1nc(CCOc2ccc(N)cn2)cs1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc(Cl)cc2c1OC(CN=[N+]=[N-])C2.COc1cc(Cl)cc2c1OC(COS(=O)(=O)c1ccc(C)cc1)C2.[N-]=[N+]=[N-].[N-]=[N+]=[N-].[Na+].[Pt]>>COc1cc(Cl)cc2c1OC(CN)C2",
        "output": "89"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)(C)OC(=O)Nc1ccc(Cl)cc1Br.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOCC.Cl[Pd]Cl.[Fe+2].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(C)OC(=O)Nc1ccc(Cl)cc1B1OC(C)(C)C(C)(C)O1",
        "output": "942"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.O=C1CCC(=O)N1Br.c1ccc(CN2CCN3c4ncccc4CC3C2)cc1>>Brc1cnc2c(c1)CC1CN(Cc3ccccc3)CCN21",
        "output": "518"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C[C@H](N)CC(=O)OCc1ccccc1.Cl.Cl.O=C(O)CCCCCCCCCCCc1ccccc1>>CN(C)C[C@@H](CC(=O)OCc1ccccc1)NC(=O)CCCCCCCCCCCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.CS(C)=O.Nc1cc(Cl)nc(Cl)c1>>Nc1cc(Cl)nc(N2CCOCC2)c1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(S(=O)(=O)Cl)cc1.O=[N+]([O-])c1cc(Br)cc2c1NCC2.c1ccncc1>>COc1ccc(S(=O)(=O)N2CCc3cc(Br)cc([N+](=O)[O-])c32)cc1",
        "output": "791"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CI.CN(C)C=O.Cc1c(C(=O)OC(C)(C)C)oc2ccc(CO)c(O)c12.O=C([O-])[O-].[K+].[K+]>>COc1c(CO)ccc2oc(C(=O)OC(C)(C)C)c(C)c12",
        "output": "62"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.COC(=O)c1cc2nc(Cl)cnc2s1.[Na+].[OH-]>>O=C(O)c1cc2nc(Cl)cnc2s1",
        "output": "152"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CO.COC(=O)C(C)=O.COC(=O)[C@H](C)Nc1ccc2c(c1)OCO2.Nc1ccc2c(c1)OCO2>>CC(C)COC(=O)[C@H](C)Nc1ccc2c(c1)OCO2",
        "output": "289"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N(c1cscn1)S(=O)(=O)c1ccc(F)c(C#N)c1.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].Oc1ccc(Cl)cc1I.[K+].[K+]>>CC(C)(C)OC(=O)N(c1cscn1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2I)c(C#N)c1",
        "output": "564"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1=COCCC1.CCOCC.CC[C@H](C)CCC[C@@H](O)COS(=O)(=O)c1ccc(C)cc1.Cc1ccc(S(=O)(=O)O)cc1.O=C([O-])O.[Na+]>>CC[C@H](C)CCC[C@H](COS(=O)(=O)c1ccc(C)cc1)OC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNC(=O)[C@H](C)N.Cc1cc(S(=O)(=O)Nc2cccc(-c3cc(C)c(C(=O)O)c(C)c3)c2)c(C)cc1Cl>>CNC(=O)[C@H](C)NC(=O)c1c(C)cc(-c2cccc(NS(=O)(=O)c3cc(C)c(Cl)cc3C)c2)cc1C",
        "output": "718"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCN(CC1CC1)c1ccc(B(O)O)c2ccccc12.CN1C(=O)CC[C@]2(C)c3ccc(Br)cc3CC[C@@H]12.ClC(Cl)Cl.O=C([O-])[O-].[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCN(CC1CC1)c1ccc(-c2ccc3c(c2)CC[C@H]2N(C)C(=O)CC[C@]32C)c2ccccc12",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.N#CCCCCBr.O.O=C([O-])[O-].[I-].[K+].[K+].[K+].c1cnc2c(c1)CC[C@H]1CCCN(Cc3nc4ccccc4[nH]3)[C@H]21>>N#CCCCCn1c(CN2CCC[C@@H]3CCc4cccnc4[C@H]32)nc2ccccc21",
        "output": "495"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCOC(=O)C(=O)c1ccc(O)c(OC)c1.ClCCCBr.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C(=O)c1ccc(OCCCCl)c(OC)c1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)N1CCN(C(=O)OC(C)(C)C)CC1c1ccc(OC)cc1.CCOC(C)=O.Cl.O=C([O-])O.[Na+]>>CCOC(=O)N1CCNCC1c1ccc(OC)cc1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cccc(C2(O)CCCNC2)c1.O=C(Cl)CCc1ccccc1>>COc1cccc(C2(O)CCCN(C(=O)CCc3ccccc3)C2)c1",
        "output": "125"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(C)=O.O=C(O)Cc1cccc(Cl)c1I.O=S(=O)(O)O>>CCOC(=O)Cc1cccc(Cl)c1I",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(NC(=O)c2ccc(-c3ccccc3)cc2)cc1NC(=O)CCl.COc1ccc(NC(=O)c2ccc(-c3ccccc3)cc2)cc1NC(=O)CN1CC2CCC(C1)O2.Cl.O[C@H]1CCCNC1>>COc1ccc(NC(=O)c2ccc(-c3ccccc3)cc2)cc1NC(=O)CN1CCC[C@H](O)C1",
        "output": "340"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1COc1ccccc1.ClCCl.O=C(O)C(F)(F)F.[Na+].[OH-]>>c1ccc(OC[C@@H]2CCCN2)cc1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N3CCC(=O)N(CC(=O)N4CCN(CCO)CC4)c4ccccc43)cc2)cc1.ClCCl>>CC(=O)OCCN1CCN(C(=O)CN2C(=O)CCN(C(=O)c3ccc(NC(=O)c4ccccc4-c4ccc(C)cc4)cc3)c3ccccc32)CC1",
        "output": "254"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1C(=O)C[C@H]1C(=O)OCc1ccccc1.CO.[H][H].[Pd]>>CN1C(=O)C[C@H]1C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCCCBr.COc1cc(C)ccc1O.O=C([O-])[O-].[K+].[K+]>>COCCCOc1ccc(C)cc1OC",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCOCCOCCOCCOCCO1.CC#N.CCC1(c2cccc(O)c2)CCCCN(C)C1=O.Cn1cncc1C(O)c1ccc(C#N)c(F)c1.[F-].[K+]>>CCC1(c2cccc(Oc3cc(C(O)c4cncn4C)ccc3C#N)c2)CCCCN(C)C1=O",
        "output": "564"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)C(Cc1cc(OCCc2ccc(-c3ccc(C(F)(F)F)cc3)nc2C)c2ccccc2c1)OC.[Li+].[OH-]>>COC(Cc1cc(OCCc2ccc(-c3ccc(C(F)(F)F)cc3)nc2C)c2ccccc2c1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=O.CC#N.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.C[Si](C)(C)CCOCn1c2cnc(C#N)cc2c2c(OC[C@@H]3CCCNC3)ccnc21.ClCCl.O.O=C([O-])[O-].[Na+].[Na+].[Na+]>>CN1CCC[C@@H](COc2ccnc3c2c2cc(C#N)ncc2n3COCC[Si](C)(C)C)C1",
        "output": "217"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN.CSC(=C[N+](=O)[O-])NCCSCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C>>CNC(=C[N+](=O)[O-])NCCSCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C",
        "output": "270"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.COc1cc(NC(=O)CCCN(C)[C@@H]2CC[C@@H](OC(=O)C(O)(c3cccs3)c3cccs3)CC2)c(Cl)cc1CO[Si](C)(C)C(C)(C)C.F.F.F>>COc1cc(NC(=O)CCCN(C)[C@@H]2CC[C@@H](OC(=O)C(O)(c3cccs3)c3cccs3)CC2)c(Cl)cc1CO",
        "output": "708"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "NC(=NO)c1cc(F)cc(F)c1.O=C(O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)N2CCOCC2)C1>>O=C(N1CCOCC1)N1CC(c2ccc(OC(F)(F)F)cc2)CC(c2nc(-c3cc(F)cc(F)c3)no2)C1",
        "output": "926"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1ccc(C2CNCC(C(=O)Nc3ccccc3)C2)cc1.CN1CCN(C(=O)Cl)CC1>>CCc1ccc(C2CC(C(=O)Nc3ccccc3)CN(C(=O)N3CCN(C)CC3)C2)cc1",
        "output": "258"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=O.CC#N.CC(=O)O.CC(=O)O.Cn1cc2cc(C(F)(F)F)cc(COCC3(c4ccccc4)CCNCC3)c2n1.[BH3-]C#N.[Na+]>>CN1CCC(COCc2cc(C(F)(F)F)cc3cn(C)nc23)(c2ccccc2)CC1",
        "output": "217"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1cnc2c(C(F)(F)F)cc(-c3ccc(C(F)(F)F)cc3)cn12.NS(=O)(=O)c1cccc(Br)c1>>NS(=O)(=O)c1cccc(C#Cc2cnc3c(C(F)(F)F)cc(-c4ccc(C(F)(F)F)cc4)cn23)c1",
        "output": "659"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Fc1cccc(CBr)c1.O=[N+]([O-])c1ccc(O)cc1F.O=[N+]([O-])c1ccc(OCc2cccc(F)c2)c(F)c1>>O=[N+]([O-])c1ccc(OCc2cccc(F)c2)cc1F",
        "output": "127"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cc(C#N)ccc1C(=O)O.c1ccc2c(c1)CCCCN2>>Cc1cc(C#N)ccc1C(=O)N1CCCCc2ccccc21",
        "output": "873"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.Cc1nn(CCO)c(C)c1Oc1cc(Cl)cc(C#N)c1.O.c1c[nH]cn1>>Cc1nn(CCO[Si](C)(C)C(C)(C)C)c(C)c1Oc1cc(Cl)cc(C#N)c1",
        "output": "193"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Nc1nc(C(=O)O)cs1.CNC.Cc1ccccc1.O=S(Cl)Cl>>CN(C)C(=O)c1csc(NC(=O)OC(C)(C)C)n1",
        "output": "747"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCCOc1c(C(=O)[O-])n(CC(C)(C)C)c(=O)c2cc(F)ccc12.CCO.Cl.O.[Na+].[OH-]>>CCCCOc1c(C(=O)O)n(CC(C)(C)C)c(=O)c2cc(F)ccc12",
        "output": "151"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1c(-c2ncco2)n(-c2ccccc2)c2ncccc2c1=O.ClC(Cl)(Cl)Cl.O.O=C1CCC(=O)N1Br>>O=c1c(CBr)c(-c2ncco2)n(-c2ccccc2)c2ncccc12",
        "output": "625"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.N#CCCNC1CC1.NS(=O)(=O)c1ccc(OCC2(F)CCC(=O)CC2)c([N+](=O)[O-])c1.[Na+]>>N#CCCN(C1CC1)C1CCC(F)(COc2ccc(S(N)(=O)=O)cc2[N+](=O)[O-])CC1",
        "output": "187"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1nc(N)c(Cl)cc1C(=O)CCC1CCN(C(=O)OC(C)(C)C)CC1.COc1nc(N)ccc1C(=O)CCC1CCN(C(=O)OC(C)(C)C)CC1>>COc1nc(N)ccc1C(=O)CCC1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C)c1ccccc1.Nc1ccc(N2CCCC2=O)cc1.O=C(Cl)OCc1ccccc1>>O=C(Nc1ccc(N2CCCC2=O)cc1)OCc1ccccc1",
        "output": "509"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.CON1CCC(NO)(C(=O)O)CC1.O=S(Cl)Cl>>COC(=O)C1(NO)CCN(OC)CC1",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)C(C)(C)CNC(=O)c1nc(C#N)c2cc(CCc3ccccc3)ccc2c1O.Cl.[Na+].[OH-]>>CC(C)(CNC(=O)c1nc(C#N)c2cc(CCc3ccccc3)ccc2c1O)C(=O)O",
        "output": "361"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ncc[nH]1.Cc1sc2nc(Cl)nc(NCc3ccc4c(c3)OCCO4)c2c1C>>Cc1sc2nc(-n3ccnc3C)nc(NCc3ccc4c(c3)OCCO4)c2c1C",
        "output": "788"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1cc2sc(-c3ccccc3)nc2cc1C=O.ClCCl.N[C@H]1CCCN[C@H]1c1ccccc1.O.[Na+]>>COc1cc2sc(-c3ccccc3)nc2cc1CN[C@H]1CCCN[C@H]1c1ccccc1",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(c1c(F)cc(OCC(=O)O)cc1F)C(F)(F)F.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1cc([C@@H](C)N)ccc1NS(C)(=O)=O.Cl.F[P-](F)(F)(F)(F)F>>Cc1cc([C@@H](C)NC(=O)COc2cc(F)c(C(C)(C)C(F)(F)F)c(F)c2)ccc1NS(C)(=O)=O",
        "output": "599"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNCC1.COC(=O)c1cc(Cl)nc(Cl)n1.ClCCl>>COC(=O)c1cc(N2CCCCC2)nc(Cl)n1",
        "output": "162"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C(=O)OC(C)(C)C)C1CCC(Oc2ncnc3sc4c(c23)[C@H](CC(=O)O)CC4)CC1.CN(C)C=O.Cl.On1nnc2ccccc21>>CCNC(=O)C[C@@H]1CCc2sc3ncnc(OC4CCC(N(C)C(=O)OC(C)(C)C)CC4)c3c21",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCC[C@H](NC(=O)OC(C)(C)C)c1cnn(C[C@H]2NC(=O)[C@H]2N)n1.CC(C)(C)OC(=O)Nc1nc(/C(=N/OC2(C(=O)OC(c3ccccc3)c3ccccc3)CC2)C(=O)O)cs1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.ClCCl.F[P-](F)(F)(F)(F)F>>CC(C)(C)OC(=O)NCC[C@H](NC(=O)OC(C)(C)C)c1cnn(C[C@H]2NC(=O)[C@H]2NC(=O)/C(=N\\OC2(C(=O)OC(c3ccccc3)c3ccccc3)CC2)c2csc(NC(=O)OC(C)(C)C)n2)n1",
        "output": "587"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=O.CSSC(C)(C)CNCCOc1cc(CO)nc(CO)c1.O=CO.[Na+].[OH-]>>CSSC(C)(C)CN(C)CCOc1cc(CO)nc(CO)c1",
        "output": "217"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc2ncc(NC(=O)OC(C)(C)C)c(Br)c2c1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc2ncc(N)c(Br)c2c1",
        "output": "877"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOCC.FB(F)F.O=C(O)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1.[BH4-].[Na+]>>O=[N+]([O-])c1cc(CO)cc([N+](=O)[O-])c1",
        "output": "72"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COc1cc2c(cc1O)C(C)(C)c1c(-c3ccc(C#N)nc3)nn(COCC[Si](C)(C)C)c1-2.Cl>>COc1cc2c(cc1O)C(C)(C)c1c(-c3ccc(C#N)nc3)n[nH]c1-2",
        "output": "813"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CC(C)(C)OC(=O)N1CCN(c2nccnc2Cl)CC1.N#Cc1ccc(B(O)O)cc1.O.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCN(c2nccnc2-c2ccc(C#N)cc2)CC1",
        "output": "875"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(C)=O.N#Cc1cc(Br)ccc1F.NN>>Nc1n[nH]c2ccc(Br)cc12",
        "output": "945"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(CC2NCCc3cc(OC)c(OC)c(OC)c32)cc1OC.COc1ccccc1CN.O=C(Br)CBr>>COc1ccccc1CNC(=O)CN1CCc2cc(OC)c(OC)c(OC)c2C1Cc1ccc(OC)c(OC)c1",
        "output": "946"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CO.COc1cc(OC)c2cnc(-c3cc(C)c(OCc4ccccc4)c(C)c3)cc2c1.[Pd]>>COc1cc(OC)c2cnc(-c3cc(C)c(O)c(C)c3)cc2c1",
        "output": "23"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CSC.NC(=O)CN1CC2CCCN2C2=C(Br)C=CCC21>>NCCN1CC2CCCN2C2=C(Br)C=CCC21",
        "output": "112"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CC(N2CCc3nc(C4CCNCC4)sc3CC2)C1.CN(C)C=O.Cc1ccc(C(=O)O)cn1.ClCCl.N=C=NC1CCCCC1.On1nnc2ccccc21>>Cc1ccc(C(=O)N2CCC(c3nc4c(s3)CCN(C3CCC3)CC4)CC2)cn1",
        "output": "256"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1.O=C(O)c1ccc(N2CCOCC2)cc1>>O=C(N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1)c1ccc(N2CCOCC2)cc1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)n1ncnc1-c1cc2n(n1)-c1cc(C3CNC3)ccc1OCC2.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)n1ncnc1-c1cc2n(n1)-c1cc(C3CN(S(C)(=O)=O)C3)ccc1OCC2",
        "output": "584"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.Cc1ccccc1.Cc1ccccc1N=C=O>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4C)cc3)c2cc1OC",
        "output": "912"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(C)=O.CCOC(=O)CBr.CN(C)C=O.ClCCl.O=C([O-])[O-].Oc1ccc2c(-c3ccccc3F)csc2c1Cl.[K+].[K+]>>CCOC(=O)COc1ccc2c(-c3ccccc3F)csc2c1Cl",
        "output": "123"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1cc(Br)cc(C(C)(C)C)c1.Cl[Pd]Cl.O.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1cc(B2OC(C)(C)C(C)(C)O2)cc(C(C)(C)C)c1",
        "output": "942"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(O)cc(Nc2ccn(COCC[Si](C)(C)C)n2)n1.[BH4-].[Li+]>>C[Si](C)(C)CCOCn1ccc(Nc2cc(O)cc(CO)n2)n1",
        "output": "546"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCOC(=O)N1CCC[C@@H](C)[C@H]1CN.CCOC(C)=O.CN(C)C=O.FC(F)(F)c1ccc(Cl)nc1.O=C([O-])[O-].[Cs+].[Cs+]>>C=CCOC(=O)N1CCC[C@@H](C)[C@H]1CNc1ccc(C(F)(F)F)cn1",
        "output": "70"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1CCNCC1.CC(C)(C)[O-].Cc1ccccc1.Cc1cnc(Cl)c(Cl)c1.O.[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Cc1cnc(N2CCN(C(=O)OC(C)(C)C)CC2)c(Cl)c1",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.N#Cc1cnc2ccc([N+](=O)[O-])cc2c1Cl.Nc1cccc(OC(F)(F)F)c1>>N#Cc1cnc2ccc([N+](=O)[O-])cc2c1Nc1cccc(OC(F)(F)F)c1",
        "output": "115"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@H]1O[C@@H](n2cc(F)c(N)nc2=O)[C@H](O)[C@@H]1O.O=C(Cl)c1ccccc1.c1ccncc1>>C[C@H]1O[C@@H](n2cc(F)c(N)nc2=O)[C@H](O)[C@@H]1OC(=O)c1ccccc1",
        "output": "51"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC[C@@H]1Oc2cc(C(=O)O)ccc2N(C(C)C)C1=O.O=S(Cl)Cl>>CC[C@@H]1Oc2cc(C(=O)Cl)ccc2N(C(C)C)C1=O",
        "output": "3"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1nc(-c2ccc(C#C[Si](C)(C)C)cc2)c(F)c(N)c1Cl.O.O=C([O-])[O-].[K+].[K+]>>C#Cc1ccc(-c2nc(C(=O)OC)c(Cl)c(N)c2F)cc1",
        "output": "337"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)c1ccc(I)cc1.CCO.COc1ccc(C=O)cc1OC.[K+].[OH-]>>COc1ccc(C=CC(=O)c2ccc(I)cc2)cc1OC",
        "output": "295"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)cc1OC.Cl.O=C(O)c1cccc2cccnc12>>COc1ccc(C2=NN(C3CCN(C(=O)c4cccc5cccnc45)CC3)C(=O)C2(C)C)cc1OC",
        "output": "256"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CCN1CCNCC1.CCN=C=NCCCN(C)C.Cl.O=C(O)CCCN1C(=O)CCC(=O)c2ccccc21>>CCN1CCN(C(=O)CCCN2C(=O)CCC(=O)c3ccccc32)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(C)=O.N#Cc1c[nH]c2nc(Nc3ccc4c(c3)CCC(=O)N4)nc(NC3CC3)c12.O=C([O-])[O-].OO.[K+].[K+]>>NC(=O)c1c[nH]c2nc(Nc3ccc4c(c3)CCC(=O)N4)nc(NC3CC3)c12",
        "output": "677"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CS(C)=O.N#Cc1c(F)cccc1-c1ccccc1.Nc1ccccc1.[H-].[Na+]>>N#Cc1c(Nc2ccccc2)cccc1-c1ccccc1",
        "output": "609"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O.O=[N+]([O-])c1cc(Br)c2ncccc2c1.[Cl-].[Fe].[NH4+]>>Nc1cc(Br)c2ncccc2c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCN1.CC(C)(C)[O-].CC(C)CN1CCN2CCN(CC(C)C)P1N(CC(C)C)CC2.Cc1c(Br)ccc2c1NC(=O)C2(C)C.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1c(N2CCOCC2)ccc2c1NC(=O)C2(C)C",
        "output": "294"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.CNOC.Cl.Cl.O.O=C(O)[C@@H]1CC(=O)N(c2ccc(OCc3cccc(F)c3)cc2)C1.O=C(n1ccnc1)n1ccnc1.c1ccncc1>>CON(C)C(=O)[C@@H]1CC(=O)N(c2ccc(OCc3cccc(F)c3)cc2)C1",
        "output": "54"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.CCOC(=O)c1cc(Cl)nc2c1c(C)nn2C1CCCCO1.[Na+].[OH-]>>Cc1nn(C2CCCCO2)c2nc(Cl)cc(C(=O)O)c12",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1c(CO)cc(C(C)(C)C)cc1[N+](=O)[O-].ClC(Cl)Cl.O=S(Cl)Cl>>COc1c(CCl)cc(C(C)(C)C)cc1[N+](=O)[O-]",
        "output": "81"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.N[C@H](CO)c1cc(Cl)cc(Br)c1>>CC(C)(C)OC(=O)N[C@H](CO)c1cc(Cl)cc(Br)c1",
        "output": "686"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COCCOc1cc2c(Cl)nc(Nc3cc(C)[nH]n3)cc2cc1F.O.OC1CCOC1.[H-].[Na+]>>COCCOc1cc2c(Cl)nc(Nc3cc(C)[nH]n3)cc2cc1OC1CCOC1",
        "output": "485"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)[C@H](C(C)C)N1Cc2cc(-c3ccc(N)cc3)ccc2C1=O.COC(=O)[C@H](C(C)C)N1Cc2cc(-c3ccc(NC(=S)Nc4ccccc4F)cc3)ccc2C1=O.FC(F)(F)c1cccc(N=C=S)c1>>COC(=O)[C@H](C(C)C)N1Cc2cc(-c3ccc(NC(=S)Nc4cccc(C(F)(F)F)c4)cc3)ccc2C1=O",
        "output": "474"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCCC(=O)Nc1nn(COCC[Si](C)(C)C)c2cc(Cl)c(Br)cc12.CCOC(C)=O.O.O=C([O-])[O-].OB(O)c1ccncc1.[Na+].[Na+]>>CCCC(=O)Nc1nn(COCC[Si](C)(C)C)c2cc(Cl)c(-c3ccncc3)cc12",
        "output": "904"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1NCCn2c(-c3cccnc3)ccc21.O=C(O)c1cc2ncc(Br)cn2n1>>CC1c2ccc(-c3cccnc3)n2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "663"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N(c1cccc2c1ccn2CC(=O)O)S(C)(=O)=O.CN(C)c1ccncc1.ClCCCl.ClCCl.[O-][n+]1cc(Cl)c(C[C@H](O)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1>>CC(C)(C)OC(=O)N(c1cccc2c1ccn2CC(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1)S(C)(=O)=O",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)N(CCN)C(C)C.O=C(O)CNC(=O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(Cl)cc2Cl)cc1>>CC(C)N(CCNC(=O)CNC(=O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(Cl)cc2Cl)cc1)C(C)C",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)=O.COC(=O)/C=C/c1ccccc1N.[BH3-]C#N.[Na+]>>COC(=O)/C=C/c1ccccc1NC(C)C",
        "output": "469"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OCC(C)(C)C(=O)N(C1CCC(=O)CC1)[C@H]1CCN(C(=O)OCc2ccccc2)C1.[BH4-].[Na+]>>CC(=O)OCC(C)(C)C(=O)N(C1CCC(O)CC1)[C@H]1CCN(C(=O)OCc2ccccc2)C1",
        "output": "91"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CN(C(=O)OCc2ccccc2)C[C@@H]1CO.CCOC(C)=O.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.c1ccncc1>>Cc1ccc(S(=O)(=O)OC[C@H]2CN(C(=O)OCc3ccccc3)C[C@H]2NC(=O)OC(C)(C)C)cc1",
        "output": "197"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCC1(CN)CC1.Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)O)cn2)c1O>>COCC1(CNC(=O)c2ccc(-n3ncc(-c4ccc(C#N)cc4C)c3O)nc2)CC1",
        "output": "674"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)Nc1ccc2c(c1)S(=O)(=O)N=C(C1=C(O)c3cccn3C(C)(Cc3ccc(F)c(Cl)c3)C1=O)N2.Cl.ClCCl.O=C([O-])C(O)C(O)C(=O)[O-].[K+].[Na+]>>CC1(Cc2ccc(F)c(Cl)c2)C(=O)C(C2=NS(=O)(=O)c3cc(N)ccc3N2)=C(O)c2cccn21",
        "output": "782"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CI.CN(C)C=O.Cc1c(C(=O)O)cc(Br)cc1[N+](=O)[O-].O=C([O-])[O-].[Na+].[Na+]>>COC(=O)c1cc(Br)cc([N+](=O)[O-])c1C",
        "output": "415"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)[Si](OCCOc1cc(CO)ccc1Br)(C(C)C)C(C)C.CCCC[N+](CCCC)(CCCC)CCCC.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C([O-])O.[I-].[Na+]>>CC(C)[Si](OCCOc1cc(CCl)ccc1Br)(C(C)C)C(C)C",
        "output": "713"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CNCc1cccc2c1OCO2.O=C(O)CCCSc1ccc(O)cc1>>CN(Cc1cccc2c1OCO2)C(=O)CCCSc1ccc(O)cc1",
        "output": "633"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCOC(C)=O.CS(=O)(=O)n1ccc2ccc(CBr)cc21.O.[C-]#N.[Na+]>>CS(=O)(=O)n1ccc2ccc(CC#N)cc21",
        "output": "39"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCC[N+](CCC)(CCC)CCC.COc1cc(C)c(C(O)c2c(C(F)(F)F)ccnc2Cl)cc1OCc1ccccc1.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-]>>COc1cc(C)c(C(=O)c2c(C(F)(F)F)ccnc2Cl)cc1OCc1ccccc1",
        "output": "852"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.COCOc1cc(O)c2c(=O)c(OC)c(-c3ccc(Cl)cc3)oc2c1CC=C(C)C.Cl>>COc1c(-c2ccc(Cl)cc2)oc2c(CC=C(C)C)c(O)cc(O)c2c1=O",
        "output": "755"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.O=C([O-])[O-].O=[N+]([O-])c1cccc2c(Cl)nccc12.[Na+].[Na+]>>Nc1cccc2c(Cl)nccc12",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCI.CC[C@@H](C)[C@@H](NC(=O)OC(C)(C)C)C(=O)O.O>>CCOC(=O)[C@H](NC(=O)OC(C)(C)C)[C@H](C)CC",
        "output": "196"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1cc(N)c(CO)c(C)n1.Cc1ccccc1.[Mn+4].[O-2].[O-2]>>Cc1cc(N)c(C=O)c(C)n1",
        "output": "520"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCCCCC(CO)CCCCCCCC.CCCCCCCCCCCC(=O)N[C@@H](C)C(=O)O.Cc1ccc(S(=O)(=O)O)cc1.O=C([O-])O.[Na+]>>CCCCCCCCCCCC(=O)N[C@@H](C)C(=O)OCC(CCCCCCCC)CCCCCCCCCC",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)CCC(Cc1ccc(Cl)cc1)N(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.CO.Cl.O.O.O.[Li+].[OH-]>>CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCC(=O)O)Cc1ccc(Cl)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2CN2C3CCCC2CC(=O)C3)cc1)C(F)(F)F.CCOC(C)=O.CO.O.[BH4-].[Na+]>>CC(O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2CN2C3CCCC2CC(O)C3)cc1)C(F)(F)F",
        "output": "91"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.Clc1cccc(C2CCNCC2)c1Cl.[Na+]>>CN1CCC(c2cccc(Cl)c2Cl)CC1",
        "output": "217"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNCC1.CCOC(C)=O.ClCCCC12CC(c3ccccc31)c1ccccc12>>c1ccc2c(c1)C1CC2(CCCN2CCCCC2)c2ccccc21",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)NC(CCC=O)Cc1ccccc1.CCOCC.ClCCl.O=C(C1CCOCC1)N1CCNCC1.[Na+].[Na+].[OH-]>>CC(C)(C)OC(=O)NC(CCCN1CCN(C(=O)C2CCOCC2)CC1)Cc1ccccc1",
        "output": "484"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cn1nc(NS(C)(=O)=O)c2c(Cl)ccc(-c3cc(N)c(C#CC4(O)CC(F)(F)C4)nc3[C@@H](N)Cc3cc(F)cc(F)c3)c21.O=C(O)Cn1nc(C(F)(F)F)c2c1C(F)(F)[C@@H]1C[C@H]21>>Cn1nc(NS(C)(=O)=O)c2c(Cl)ccc(-c3cc(N)c(C#CC4(O)CC(F)(F)C4)nc3[C@H](Cc3cc(F)cc(F)c3)NC(=O)Cn3nc(C(F)(F)F)c4c3C(F)(F)[C@@H]3C[C@H]43)c21",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccc(I)cc1.CN(C)C=O.Cc1n[nH]c(C)c1CC(=O)OC(C)(C)C.O.O=C([O-])[O-].[K+].[K+]>>Cc1nn(Cc2ccc(I)cc2)c(C)c1CC(=O)OC(C)(C)C",
        "output": "635"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OCCCCBr.CN(C)C=O.Cl.O.O=C([O-])[O-].[K+].[K+].c1cc(N2CCNCC2)c2ccsc2c1>>CC(=O)OCCCCN1CCN(c2cccc3sccc23)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cc1ccc(-c2ccc3c(c2)C=C(C(=O)N2CCC(NC(=O)C(F)(F)F)CC2)CCO3)cc1.[Na+].[OH-]>>Cc1ccc(-c2ccc3c(c2)C=C(C(=O)N2CCC(N)CC2)CCO3)cc1",
        "output": "805"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)cc1.Cl.O.[Li+].[OH-]>>O=C(O)c1ccc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CCO.CS(=O)(=O)c1ccc2c(c1)CC(=O)N2.O=Cc1[nH]c2c(c1CCC(=O)O)CCCCC2>>CS(=O)(=O)c1ccc2c(c1)/C(=C/c1[nH]c3c(c1CCC(=O)O)CCCCC3)C(=O)N2",
        "output": "911"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.COC(=O)Cc1ccc(C#Cc2ccc(C3(OC)CC3)cc2)cc1.[Na+].[OH-]>>COC1(c2ccc(C#Cc3ccc(CC(=O)O)cc3)cc2)CC1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NC1C2CC3CC1CC(O)(C3)C2.O=C(O)c1ccc(OCCC2CCN(S(=O)(=O)c3ccccn3)CC2)cc1>>O=C(NC1C2CC3CC1CC(O)(C3)C2)c1ccc(OCCC2CCN(S(=O)(=O)c3ccccn3)CC2)cc1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C(CC)Oc1ccc(OC(F)(F)F)cc1.CO.O.[Li+].[OH-]>>CCC(Oc1ccc(OC(F)(F)F)cc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.COc1ccc2ccc(N)nc2n1.COc1cccc(C(=O)O)c1.O>>COc1cccc(C(=O)Nc2ccc3ccc(OC)nc3n2)c1",
        "output": "744"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)OCCN(C(=O)c1c(Cl)ncnc1Cl)c1ccc(Br)cc1.CO.Cl>>O=C(c1c(Cl)ncnc1Cl)N(CCO)c1ccc(Br)cc1",
        "output": "708"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrC(Br)(Br)Br.ClCCl.OCc1cc2c(cc1I)CCC2.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>BrCc1cc2c(cc1I)CCC2",
        "output": "750"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)[O-].COc1cc(C(C)=O)cnc1Cl.OCC(F)(F)F.[Cl-].[K+].[NH4+]>>COc1cc(C(C)=O)cnc1OCC(F)(F)F",
        "output": "433"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COC(=O)CCCc1cccs1.O=P(Cl)(Cl)Cl>>COC(=O)CCCc1ccc(C=O)s1",
        "output": "617"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCN(C(C)C)C(C)C.COc1ccc(CN2Cc3c(F)c(Cl)nc(Cl)c3C2=O)c(OC)c1.Cl.N[C@@H]1CCCC(F)(F)[C@@H]1N>>COc1ccc(CN2Cc3c(F)c(N[C@@H]4CCCC(F)(F)[C@@H]4N)nc(Cl)c3C2=O)c(OC)c1",
        "output": "70"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(B(O)O)c(F)c1.Fc1ccc(OCc2cn3cc(Br)cnc3n2)cc1>>Cc1ccc(-c2cnc3nc(COc4ccc(F)cc4)cn3c2)c(F)c1",
        "output": "871"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.CN1C(=O)C2(CCCc3sc(Br)cc32)N=C1N.Cl[Pd]Cl.N#Cc1cccc(B(O)O)c1.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CN1C(=O)C2(CCCc3sc(-c4cccc(C#N)c4)cc32)N=C1N",
        "output": "864"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "N#Cc1cc(Cl)ccc1N.O=C(Cl)c1ccc(Cl)nc1>>N#Cc1cc(Cl)ccc1NC(=O)c1ccc(Cl)nc1",
        "output": "642"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COc1cc2nc(-c3cccc([N+](=O)[O-])c3)nc(Nc3ccc4c(cnn4C(=O)OC(C)(C)C)c3)c2cc1OCCN(C)C.[H][H].[Pd]>>COc1cc2nc(-c3cccc(N)c3)nc(Nc3ccc4c(cnn4C(=O)OC(C)(C)C)c3)c2cc1OCCN(C)C",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CNCCN1.CN1CCCC1=O.COc1cc(N2CCN(C(=O)CCl)CC2)ccc1Cl>>COc1cc(N2CCN(C(=O)CN3CCNCC3)CC2)ccc1Cl",
        "output": "340"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@@H]1COC(=O)N1c1ccc(C(=O)O)cc1.Cc1cnc(N2CCNCC2)c(C)n1.Cl>>Cc1cnc(N2CCN(C(=O)c3ccc(N4C(=O)OC[C@H]4C)cc3)CC2)c(C)n1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.CCC1=C(C)CN(C(=O)NCC2CCOc3cc(O)c(S(N)(=O)=O)cc32)C1=O.CCI.Cl.O=C([O-])[O-].[K+].[K+]>>CCOc1cc2c(cc1S(N)(=O)=O)C(CNC(=O)N1CC(C)=C(CC)C1=O)CCO2",
        "output": "198"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CNC(=O)n1ccc2cc([N+](=O)[O-])ccc21.CO.O.[Cl-].[Fe].[NH4+]>>CNC(=O)n1ccc2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.COc1ccc(C(=O)O)cc1Br.Cc1cc(N2CCOCC2)ccc1N.O.On1nnc2ccccc21>>COc1ccc(C(=O)Nc2ccc(N3CCOCC3)cc2C)cc1Br",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCCCN(C)Cc1cc(C)cc(C(=O)OC)c1.CO.O.[Li+].[OH-]>>CCCCCN(C)Cc1cc(C)cc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C(CC(C)C)c1cc(-c2ccc(C(F)(F)F)cc2)cc(C2CCCN(C(CC)CC)C2)c1.[K+].[OH-]>>CCC(CC)N1CCCC(c2cc(-c3ccc(C(F)(F)F)cc3)cc(C(CC(C)C)C(=O)O)c2)C1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(C)=O.Cc1ccccc1.Cc1ccccc1B(O)O.O.O=C(Nc1ccc2nc(N3CCOCC3)ccc2c1Br)OCc1ccccc1.O=C([O-])O.[Na+]>>Cc1ccccc1-c1c(NC(=O)OCc2ccccc2)ccc2nc(N3CCOCC3)ccc12",
        "output": "909"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCOc1ccc(Cn2c(C)nc3ccc(O)cc32)c(Cl)c1.CCOC(=O)C(C)(C)Br>>CCCCCOc1ccc(Cn2c(C)nc3ccc(OC(C)(C)C(=O)OCC)cc32)c(Cl)c1",
        "output": "305"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)c1ccncc1.ClCCl.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.[O-][n+]1cc(Cl)c(C[C@H](O)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1>>O=C(Oc1ccc([N+](=O)[O-])cc1)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1",
        "output": "662"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.N#Cc1ccc(C(O)COCc2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)cc1>>CS(=O)(=O)OC(COCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)c1ccc(C#N)cc1",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCNCC1.Clc1cc2c(Nc3ccc4c(cnn4Cc4ccccc4)c3)ncnc2cn1>>CN1CCN(c2cc3c(Nc4ccc5c(cnn5Cc5ccccc5)c4)ncnc3cn2)CC1",
        "output": "220"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCO.CCN(CC)CC.Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(O)C(=O)O)[C@@H](O)[C@H]1O.O=S(=O)(O)O>>CCCCCCOC(=O)C(O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.COc1ccc(CC(=O)c2ccccc2)cc1.[K+].[OH-]>>O=C(Cc1ccc(O)cc1)c1ccccc1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCCC.CCOC(C)=O.CN(C)C=O.Cc1n[nH]c2ccc(Br)cc12.O.[Li]C(C)(C)C>>Cc1n[nH]c2ccc(C=O)cc12",
        "output": "638"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(O)c(C23CC4CC(CC(C4)C2)C3)c1.O=S(=O)(O)Cl>>Cc1cc(C23CC4CC(CC(C4)C2)C3)c(O)c(S(=O)(=O)Cl)c1",
        "output": "357"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N1CCc2cc([N+](=O)[O-])cnc21.CCO.[H][H].[Pd]>>CC(=O)N1CCc2cc(N)cnc21",
        "output": "269"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCc1ccc(C(=O)O)cc1O.CO.O=S(=O)(O)O>>CCc1ccc(C(=O)OC)cc1O",
        "output": "33"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1cc(-c2ccc(CN)o2)c(C)[nH]c1=O.COc1ccc(C(=O)Cl)cc1>>CCc1cc(-c2ccc(CNC(=O)c3ccc(OC)cc3)o2)c(C)[nH]c1=O",
        "output": "271"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(N3CC[C@H](N)C3)nc2s1.CCN(C(C)C)C(C)C.CN(C)C=O.ClCCCl.O=C(O)CO.On1nnc2ccccc21>>CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(N3CC[C@H](NC(=O)CO)C3)nc2s1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COc1ccc(F)cc1C(C)(C)c1cc(F)ccc1O.ClCCl.O>>CC(C)(c1cc(F)ccc1O)c1cc(F)ccc1O",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C[C@@H](C1CC1)N(Cc1ccccc1)C(=O)CN1C(=O)NC2(CCc3cc(OC4CN(C(=O)OC(C)(C)C)C4)ccc32)C1=O.ClCCl.O=C(O)C(F)(F)F>>C[C@@H](C1CC1)N(Cc1ccccc1)C(=O)CN1C(=O)NC2(CCc3cc(OC4CNC4)ccc32)C1=O",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1cc(C(=O)O)cc(C(C)(C)C)c1O.ClC(Cl)Cl.O=S(Cl)Cl>>CC(C)(C)c1cc(C(=O)Cl)cc(C(C)(C)C)c1O",
        "output": "3"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CN(C)C=O.O=C1CCC(=O)N1I.Oc1ncccc1C(F)(F)F>>Oc1ncc(I)cc1C(F)(F)F",
        "output": "783"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COC(=O)c1c(NS(=O)(=O)c2ccc(F)cc2CCCN2CCCC2)ccc2c1OC[C@@H]1OCC[C@H]21.O.O=CO.[Li+].[OH-]>>O=C(O)c1c(NS(=O)(=O)c2ccc(F)cc2CCCN2CCCC2)ccc2c1OC[C@@H]1OCC[C@H]21",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(=O)Cl.CCN(CC)CC.ClCCl.O.Oc1ccc(CCOCCCCl)cc1>>CC(C)(C)C(=O)Oc1ccc(CCOCCCCl)cc1",
        "output": "111"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)C(=O)CC(=O)C(C)(C)C.CN1CCCC1=O.FC(F)(F)Oc1ccc(I)cc1.O=C([O-])[O-].Oc1ccc(Br)cc1.[Cs+].[Cs+]>>FC(F)(F)Oc1ccc(Oc2ccc(Br)cc2)cc1",
        "output": "382"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1sc(-c2ccccc2)nc1OC.CO.[Na+].[OH-]>>COc1nc(-c2ccccc2)sc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.Cc1ccc2c(n1)COC2=O.O=[Se]=O>>O=Cc1ccc2c(n1)COC2=O",
        "output": "619"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCn1ccc2c(Br)cccc21.O.[Na+].[OH-]>>CC(C)(C)OC(=O)NCCn1ccc2c(Br)cccc21",
        "output": "631"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CCOCCOCCOCCOCCN=[N+]=[N-].CCO.[Pd]>>CC(C)(C)OC(=O)CCOCCOCCOCCOCCN",
        "output": "89"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCNCC1.COC(=O)c1cnc(Cl)nc1.ClCCl>>COC(=O)c1cnc(N2CCCN(C)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.O=C(O)c1ccc(Br)cc1[N+](=O)[O-].[Pt]>>Nc1cc(Br)ccc1C(=O)O",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CNC.Cl.ClCCl.O=C(O)Cc1ccc(Br)cc1.O=C(n1ccnc1)n1ccnc1>>CN(C)C(=O)Cc1ccc(Br)cc1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccccc1.CN(C)C=O.O.O=C([O-])[O-].Oc1ccc(Cl)nc1-c1cc2c(F)cccc2[nH]1.[K+].[K+]>>Fc1cccc2[nH]c(-c3nc(Cl)ccc3OCc3ccccc3)cc12",
        "output": "623"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)Cn1cc(C(=O)NCCCO)c(Nc2ccc(I)cc2F)cc1=O.CCO.CCOC(C)=O.CO.[Na+].[OH-]>>O=C(O)Cn1cc(C(=O)NCCCO)c(Nc2ccc(I)cc2F)cc1=O",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(C(=O)O)c1.Cc1cc(N)nn1C(=O)OC(C)(C)C.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+]>>COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(C(=O)Nc2cc(C)n(C(=O)OC(C)(C)C)n2)c1",
        "output": "917"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.O=C([O-])[O-].O=Cc1c(F)cc(O)cc1Cl.[K+].[K+]>>COc1cc(F)c(C=O)c(Cl)c1",
        "output": "62"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCCc1oc2ccccc2c1-c1ncc(-c2ccc3cc(OCC(=O)OC)ccc3c2)o1.Cl.O.[Na+].[OH-]>>CCCCc1oc2ccccc2c1-c1ncc(-c2ccc3cc(OCC(=O)O)ccc3c2)o1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)NC(C)C.CCN=C=NCCCN(C)C.COc1ccccc1C1(O)C(O)CC(c2ccccc2)(c2ccccc2)C2CNCC21.Cl.Cl.ClCCl.O.O=C(O)Cc1c[nH]c2ccccc12.On1nnc2ccccc21.[Cl-].[Na+]>>COc1ccccc1C1(O)C(O)CC(c2ccccc2)(c2ccccc2)C2CN(C(=O)Cc3c[nH]c4ccccc34)CC21",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CI.C[C@@H](CNC(=O)OC(C)(C)C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1F.C[Si](C)(C)[N-][Si](C)(C)C.[Na+]>>C[C@@H](CN(C)C(=O)OC(C)(C)C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1F",
        "output": "803"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.CN(Cc1c[nH]c2cc(Br)ccc12)C(=O)OC(C)(C)C.O=S(=O)(Cl)c1cccc(F)c1.[Cl-].[H-].[NH4+].[Na+]>>CN(Cc1cn(S(=O)(=O)c2cccc(F)c2)c2cc(Br)ccc12)C(=O)OC(C)(C)C",
        "output": "648"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCC(C(=O)O)N1CCC(CNC(=O)c2cc(Cl)c(N)nc2OC)CC1.CCN(C(C)C)C(C)C.CCOP(=O)(C#N)OCC.CN(C)C=O.CNC.Cl>>CCCCC(C(=O)N(C)C)N1CCC(CNC(=O)c2cc(Cl)c(N)nc2OC)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(CCN)CC1.CN(C)C(=O)COc1cc(Cl)ccc1C(=O)O.CN(C)C=O.ClCCl.O=C([O-])O.O=C(n1ccnc1)n1ccnc1.[Na+]>>CN(C)C(=O)COc1cc(Cl)ccc1C(=O)NCCN1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.COC(C)O.COCC#Cc1cc(Cl)c(Nc2ncnc3cc(OCCCl)c(OC)cc23)c2c1OCO2.NCCCO>>COCC#Cc1cc(Cl)c(Nc2ncnc3cc(OCCNCCCO)c(OC)cc23)c2c1OCO2",
        "output": "279"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.Cc1nc2cccc(F)c2cc1Br.O.O=C1CCC(=O)N1Br>>Fc1cccc2nc(CBr)c(Br)cc12",
        "output": "590"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.Cn1ccnc1Sc1cc(C(=O)Nc2ccc(Br)cn2)c([N+](=O)[O-])cc1F.[Cl-].[Fe].[NH4+]>>Cn1ccnc1Sc1cc(C(=O)Nc2ccc(Br)cn2)c(N)cc1F",
        "output": "486"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN.COCCn1c(S(C)(=O)=O)nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c2c1=O>>CNc1nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c2c(=O)n1CCOC",
        "output": "629"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.O.O=Cc1ccc(OCCCl)cc1.[H-].[Na+].c1c[nH]cn1>>O=Cc1ccc(OCCn2ccnc2)cc1",
        "output": "611"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(N)(C#N)COc1cc(Cl)c2c(c1Cl)B(O)OC2.CCN(C(C)C)C(C)C.Cl.O=C(Cl)c1ccc(OC(F)(F)F)cc1>>CC(C#N)(COc1cc(Cl)c2c(c1Cl)B(O)OC2)NC(=O)c1ccc(OC(F)(F)F)cc1",
        "output": "271"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#CCO.C1CN2CCN1CC2.CC#N.CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C.CCOCC.COc1cc(Br)ccc1[N+](=O)[O-]>>COc1cc(C#CCO)ccc1[N+](=O)[O-]",
        "output": "659"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCCCCC.CCOC(=O)CCc1cn(-c2cc(C(F)(F)F)ccn2)nc1C(C)C.Cl.[H-]>>CC(C)c1nn(-c2cc(C(F)(F)F)ccn2)cc1CCCO",
        "output": "225"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CC(C)(C)OC(=O)N1CCN(c2ccc(OCCCCl)cc2)CC1.CCC(C)=O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)CC1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cc1cc(Br)cc(CBr)c1.O.[C-]#N.[K+]>>Cc1cc(Br)cc(CC#N)c1",
        "output": "39"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O=C(NCC(=O)N1CCN(Cc2ccccc2)CC1)c1ccc(Oc2ccccc2)cc1.[H][H].[Pd]>>O=C(NCC(=O)N1CCNCC1)c1ccc(Oc2ccccc2)cc1",
        "output": "84"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1.O.O=C(O)C(F)(F)F.O=C(O)c1ccc(-c2ccsc2)cc1.On1nnc2ccccc21>>O=C(NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1)c1ccc(-c2ccsc2)cc1",
        "output": "718"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1CNCC(C)C1.Cc1ccc(-c2oncc2C(=O)O)cc1>>Cc1ccc(-c2oncc2C(=O)N2CC(C)CC(C)C2)cc1",
        "output": "975"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2[nH]nc(-c3cc4ccccc4s3)c2c1F.Cl.[Na+].[OH-]>>O=C(O)c1ccc2[nH]nc(-c3cc4ccccc4s3)c2c1F",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.COc1cc(C(=O)O)ccc1Cc1cn(Cc2ccc3ccc(Cl)cc3n2)c2ccc(NC(=O)OC3CCCC3)cc12.Cc1ccccc1S(N)(=O)=O.Cl.ClCCl>>COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(Cc2ccc3ccc(Cl)cc3n2)c2ccc(NC(=O)OC3CCCC3)cc12",
        "output": "579"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.C=CCN(CC=C)Cc1ccc(C(=O)O)s1.CC(C)(C)OC(=O)Nc1ccccc1N.O=C(n1ccnc1)n1ccnc1>>C=CCN(CC=C)Cc1ccc(C(=O)Nc2ccccc2NC(=O)OC(C)(C)C)s1",
        "output": "822"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.C1COCCO1.CCCc1cc(O)nc(S)n1.[Na+].[OH-]>>CCCc1cc(O)nc(SCc2ccccc2)n1",
        "output": "699"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.N#Cc1ccnc2[nH]ncc12.[NH4+].[Ni].[OH-]>>NCc1ccnc2[nH]ncc12",
        "output": "175"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1=COCCC1.C[C@]12CC[C@H](O)CC1=CC(=O)[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12.Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1>>C[C@]12CC[C@H](OC3CCCCO3)CC1=CC(=O)[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12",
        "output": "141"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(C=O)ccc1Oc1ccc(C(N)=O)cn1.NCCc1ccc(F)cc1>>COc1cc(CNCCc2ccc(F)cc2)ccc1Oc1ccc(C(N)=O)cn1",
        "output": "468"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)c1cn(C)c(=O)cc1Nc1ccc(I)cc1F.[Na+].[OH-]>>Cn1cc(C(=O)O)c(Nc2ccc(I)cc2F)cc1=O",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)c1cnc(NCc2cccs2)nc1-c1ccccc1.O.[K+].[OH-]>>O=C(O)c1cnc(NCc2cccs2)nc1-c1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCCCc1nc(CO)c(Br)[nH]1.[Mn+4].[O-2].[O-2]>>CCCCc1nc(C=O)c(Br)[nH]1",
        "output": "287"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.CC(C)OC(C)C.CCO.OC(c1ccccc1)(c1ccccc1)C1CCN(Cc2ccccc2)CC1.[Pd]>>OC(c1ccccc1)(c1ccccc1)C1CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)CNC(=O)C1=C(O)c2cc(Cl)c(Cl)cc2C(C)(C)C1=O.O=C(O)C(F)(F)F>>CC1(C)C(=O)C(C(=O)NCC(=O)O)=C(O)c2cc(Cl)c(Cl)cc21",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)CC1CN=C(c2cc3cccc(N(C)S(=O)(=O)c4ccccc4C(F)(F)F)c3[nH]2)S1.CO.O=C(O)CC(O)(CC(=O)O)C(=O)O.[BH4-].[Li+]>>CN(c1cccc2cc(C3=NCC(CCO)S3)[nH]c12)S(=O)(=O)c1ccccc1C(F)(F)F",
        "output": "225"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCCCCC/C=C/C(=O)N1CCC(O)CC1.CI.O.[H-].[Na+]>>CCCCCCC/C=C/C(=O)N1CCC(OC)CC1",
        "output": "140"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)C(Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)cccc1Cl)NC1=C(Cl)C(=O)C12CCCCC2.O=C(O)C(Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)cncc1Cl)NC1=CC(=O)C12CCCCC2>>O=C(O)C(Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)cccc1Cl)NC1=C(Cl)C(=O)C12CCCCC2",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cn1c(C(N)=O)cc2cc(C#N)cc(Br)c21.OB(O)c1ccc(Cl)cc1F>>Cn1c(C(N)=O)cc2cc(C#N)cc(-c3ccc(Cl)cc3F)c21",
        "output": "833"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(=O)(=O)Nc1ccccc1.Cl.ClCCl.O=C(Cl)CCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CS(=O)(=O)Nc1ccc(C(=O)CCl)cc1",
        "output": "31"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)NC(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COCC(=O)O.F[P-](F)(F)(F)(F)F.Nc1nc2ccc(OS(=O)(=O)c3ccc(F)cc3)cc2s1.O>>COCC(=O)Nc1nc2ccc(OS(=O)(=O)c3ccc(F)cc3)cc2s1",
        "output": "681"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.O=C(O)c1ccncc1O.O=S(=O)(O)O>>CCOC(=O)c1ccncc1O",
        "output": "33"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCOC(C)=O.ClCCl.O.OCC1CCN(c2ncnc3[nH]cnc23)CC1>>O=CC1CCN(c2ncnc3[nH]cnc23)CC1",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(O)C(N)CCCC(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(OCCC(C(F)(F)F)C(F)(F)F)c2nc(C)c(C(=O)O)n2c1.Cl.F[P-](F)(F)(F)(F)F.O>>Cc1cc(OCCC(C(F)(F)F)C(F)(F)F)c2nc(C)c(C(=O)NC(CCCC(F)(F)F)C(C)(C)O)n2c1",
        "output": "697"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.CCOC(C)=O.CCOC(C)O[C@@H]1OC=C(CO)[C@H]2CC[C@H](C)[C@@H]12.ClCCl.c1ccncc1>>CCOC(C)O[C@@H]1OC=C(COC(C)=O)[C@H]2CC[C@H](C)[C@@H]12",
        "output": "155"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)CC1(c2ccc3ccccc3c2)CCN(Cc2ccccc2)CC1.CCOCC.ClCCl.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OCCC1(c2ccc3ccccc3c2)CCN(Cc2ccccc2)CC1",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cc2c([nH]1)CCC2Cc1cccc(-c2ccc(C(F)(F)F)cc2)c1.[Li+].[OH-]>>O=C(O)c1cc2c([nH]1)CCC2Cc1cccc(-c2ccc(C(F)(F)F)cc2)c1",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(N)(C#N)C1CC1.CCN(CC)CC.ClCCl.O=C(Cl)c1cccc(CCl)c1>>CC(C#N)(NC(=O)c1cccc(CCl)c1)C1CC1",
        "output": "271"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.NC(=O)c1ccc(F)c2c1CC(NCCC(=O)c1cn(S(=O)(=O)c3ccccc3)c3ccc(F)cc13)CO2.O.O=C([O-])[O-].[K+].[K+]>>NC(=O)c1ccc(F)c2c1CC(NCCC(=O)c1c[nH]c3ccc(F)cc13)CO2",
        "output": "771"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCNCc1ccccc1OC.O=C(O)CCCSc1ccc(O)cc1>>CCN(Cc1ccccc1OC)C(=O)CCCSc1ccc(O)cc1",
        "output": "633"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O=[N+]([O-])c1ccccc1C1CC1C1CC1.[C].[H][H].[Pt]>>Nc1ccccc1C1CC1C1CC1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCc1ccc(C2CC(C(=O)O)CN(C(=O)N3CCOCC3)C2)cc1.Cc1cccc(C(=N)NO)c1>>CCc1ccc(C2CC(c3nc(-c4cccc(C)c4)no3)CN(C(=O)N3CCOCC3)C2)cc1",
        "output": "895"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cl.O=C(Cc1ccc2c(c1)CNC2)N[C@H]1Cc2cccc(C(=O)O)c2OB1O>>COC(=O)c1cccc2c1OB(O)[C@@H](NC(=O)Cc1ccc3c(c1)CNC3)C2",
        "output": "33"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)C1CCN(C(=O)OC(C)(C)C)CC1NS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1.CO.O.[Li+].[OH-]>>Cc1cc(COc2ccc(S(=O)(=O)NC3CN(C(=O)OC(C)(C)C)CCC3C(=O)O)cc2)c2ccccc2n1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.Cc1ccc(C(=O)O)cn1.ClCCl.Nc1c[nH]c2ncc(Br)c(F)c12.O.O=C1OCCN1P(=O)(Cl)N1CCOC1=O.[Li+].[OH-]>>Cc1ccc(C(=O)Nc2c[nH]c3ncc(Br)c(F)c23)cn1",
        "output": "863"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=O.O.O=C(O)CCCCNCc1ccc([N+](=O)[O-])cc1.[BH3-]C#N.[Na+]>>CN(CCCCC(=O)O)Cc1ccc([N+](=O)[O-])cc1",
        "output": "69"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1C(C(=O)Nc2ccc(Cl)cc2)C1C(=O)Nc1ccc(-n2ccc(OCC(=O)OC(C)(C)C)cc2=O)cc1F.O=C(O)C(F)(F)F>>CCOC(=O)C1C(C(=O)Nc2ccc(Cl)cc2)C1C(=O)Nc1ccc(-n2ccc(OCC(=O)O)cc2=O)cc1F",
        "output": "278"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(O)C(=O)O.C[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2cccs2)nc2ccccc12)C1CCCCC1>>C[C@H](NC(=O)c1c(CN2CCN(C(=O)C(C)(C)O)CC2)c(-c2cccs2)nc2ccccc12)C1CCCCC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cc1ccccc1-n1c(CF)nc2ccc([N+](=O)[O-])cc2c1=O.Cl.ClC(Cl)Cl.O.O=C([O-])O.[Na+]>>Cc1ccccc1-n1c(CF)nc2ccc(N)cc2c1=O",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.Cc1cc([N+](=O)[O-])c(C)c(Cl)c1Cl.[Pd]>>Cc1cc(N)c(C)c(Cl)c1Cl",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc2c(cc1N)CCN(CC(=O)N(C)C)CC2.Clc1ncc(Cl)c(Nc2ccccc2-n2cccn2)n1>>COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3-n3cccn3)n1)CCN(CC(=O)N(C)C)CC2",
        "output": "808"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)c1ccc(CBr)cc1.CS(=O)(=O)c1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2/C=C/c2ccc(Br)cc2)cc1.OB(O)c1cccc(C(F)(F)F)c1>>CS(=O)(=O)c1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2/C=C/c2ccc(-c3cccc(C(F)(F)F)c3)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1cccc(Br)c1.CNC1CCCC1>>CN(c1cccc(Br)c1)C1CCCC1",
        "output": "294"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCN.Cl[Ti](Cl)(Cl)Cl.NC(=O)c1ccc(Oc2ccc3c(c2)CCC3=O)nc1.[BH3-]C#N.[Na+]>>CCCCCCNC1CCc2cc(Oc3ccc(C(N)=O)cn3)ccc21",
        "output": "693"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cnc(Cl)nc1.CS(=O)(=O)N1CC=C(c2cc3c(cn2)O[C@@H](C2CCNCC2)C3)CC1>>COc1cnc(N2CCC([C@H]3Cc4cc(C5=CCN(S(C)(=O)=O)CC5)ncc4O3)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(-c2cc(CN3CCNCC3)ccn2)cc(OC)c1OC.COc1cc(C=CC(=O)O)cc(OC)c1OC>>COc1cc(C=CC(=O)N2CCN(Cc3ccnc(-c4cc(OC)c(OC)c(OC)c4)c3)CC2)cc(OC)c1OC",
        "output": "517"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)S(=O)(=O)c1cccc(F)c1Nc1nc(Cl)ncc1Cl.CCN1C(=O)CCC(C)(C)c2ccc(N)cc21>>CCN1C(=O)CCC(C)(C)c2ccc(Nc3ncc(Cl)c(Nc4c(F)cccc4S(=O)(=O)C(C)C)n3)cc21",
        "output": "808"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.O=C(O)c1cccc(-c2cccc([N+](=O)[O-])c2O)c1.[Pd]>>Nc1cccc(-c2cccc(C(=O)O)c2)c1O",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Nc1ncccc1-c1ccc(OCc2ccccc2)c(F)c1.O=[Pt]=O>>Nc1ncccc1-c1ccc(O)c(F)c1",
        "output": "23"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(Sc2ccc3c(c2)C=C(C)C(C)(C)O3)cc1.Cc1cc(C)nc(C)c1.ClCCl.[I-].[Li+]>>CC1=Cc2cc(Sc3ccc(O)cc3)ccc2OC1(C)C",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)c1ccc(Nc2nc(C(C)C)nc3c2CCN(c2ncccc2C(F)(F)F)CC3)cc1.CO.[BH4-].[Na+]>>CC(C)c1nc2c(c(Nc3ccc(C(C)O)cc3)n1)CCN(c1ncccc1C(F)(F)F)CC2",
        "output": "24"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)O.CCOC(=O)CCCc1cccc(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)c1C(F)(F)F.Cl.O.[Na+].[OH-]>>CC(C)Oc1ccc(-c2nc(-c3cccc(CCCC(=O)O)c3C(F)(F)F)no2)cc1C#N",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.ClCCCl.O=C1COC1.OC1CCNCC1.[Na+]>>OC1CCN(C2COC2)CC1",
        "output": "983"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.COc1cc2c(Cl)ncnc2cc1OCCCN1CCN(C(C)=O)CC1.O=C([O-])[O-].Oc1ccc2[nH]ncc2c1.[Cs+].[Cs+]>>COc1cc2c(Oc3ccc4[nH]ncc4c3)ncnc2cc1OCCCN1CCN(C(C)=O)CC1",
        "output": "668"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)COc1ccc(OCc2ccccc2)cc1OCc1ccccc1.CO.[K+].[OH-]>>O=C(O)COc1ccc(OCc2ccccc2)cc1OCc1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCC.ClCCl.O=C(O)c1cccnc1-n1cc(F)c(-c2ccccc2)n1.[Cl-].[NH3+]C(Cc1ccccc1)C(O)C(=O)NC1CC1>>O=C(NC(Cc1ccccc1)C(O)C(=O)NC1CC1)c1cccnc1-n1cc(F)c(-c2ccccc2)n1",
        "output": "674"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COc1cc(F)cc(Br)c1.ClCCl>>Oc1cc(F)cc(Br)c1",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNC1.O=c1c2cnn(C3CCCCO3)c2c2cnc(-c3cccnc3F)cc2n1CC(F)(F)F>>O=c1c2cnn(C3CCCCO3)c2c2cnc(-c3cccnc3N3CCCC3)cc2n1CC(F)(F)F",
        "output": "756"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(C)=O.ClCCl.O=CCCc1cc(-c2cccc([N+](=O)[O-])c2)no1.[Na+].c1ccc(N2CCNCC2)cc1>>O=[N+]([O-])c1cccc(-c2cc(CCCN3CCN(c4ccccc4)CC3)on2)c1",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCn1cc(-c2cnc(N)c(-c3ccc(C(=O)OC)c(F)c3)n2)cn1.CO.Cl.[Li+].[OH-]>>CCn1cc(-c2cnc(N)c(-c3ccc(C(=O)O)c(F)c3)n2)cn1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCCOc1nc(N)c2[nH]c(=O)n(CCCNC3CCN(Cc4ccccc4)CC3)c2n1.CN1CCCC1=O.COC(=O)Cc1cccc(C=O)c1.[Na+]>>CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(Cc3cccc(CC(=O)OC)c3)C3CCN(Cc4ccccc4)CC3)c2n1",
        "output": "567"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.CN(C)CCCO.O=C1CSc2cc(O)ccc2N1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN(C)CCCOc1ccc2c(c1)SCC(=O)N2",
        "output": "478"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)O.Cl.Clc1nc(Cl)c2ccccc2n1.Nc1ccncc1>>Clc1nc(Nc2ccncc2)c2ccccc2n1",
        "output": "352"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1nnc(C(C)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2CCO3)CO[Si](C)(C)C(C)(C)C)[nH]1.[F-]>>Cc1nnc(C(C)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2CCO3)CO)[nH]1",
        "output": "708"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "N#Cc1ccc(Br)cc1.O=Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1.OB(O)c1ccc(C(F)(F)F)cc1>>N#Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCc1nc2cnc3ccccc3c2n1CCC(=O)OCC.CNC>>CCCc1nc2cnc3ccccc3c2n1CCC(=O)N(C)C",
        "output": "494"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN1CCNC[C@@H]1C.Cc1c(-c2cnn(-c3ccc(C(=O)O)cn3)c2O)ccc(C#N)c1F>>CCN1CCN(C(=O)c2ccc(-n3ncc(-c4ccc(C#N)c(F)c4C)c3O)nc2)C[C@@H]1C",
        "output": "256"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COCc1cc(Nc2ccc(Cl)c(Cl)c2)ncn1.ClCCl.O=C([O-])[O-].[Na+].[Na+]>>OCc1cc(Nc2ccc(Cl)c(Cl)c2)ncn1",
        "output": "423"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COc1c(Cl)ncnc1Cl.NCCO.O=C([O-])[O-].[K+].[K+]>>COc1c(Cl)ncnc1NCCO",
        "output": "166"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(CC)CC.Cc1ccccc1C(=O)Cl.NCCOc1ccc(OC(F)(F)F)cc1>>Cc1ccccc1C(=O)NCCOc1ccc(OC(F)(F)F)cc1",
        "output": "271"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.N#Cc1cccc(CBr)c1.OCc1ncn(C(c2ccccc2)(c2ccccc2)c2ccccc2)n1.[H-].[Na+]>>N#Cc1cccc(COCc2ncn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)c1",
        "output": "464"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC=C(c2ccc(NC(=O)N3CCc4ccccc4C3)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(Nc1ccc(C2=CCNCC2)cc1)N1CCc2ccccc2C1",
        "output": "800"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O.CC(C)(C)OC(=O)N1CCC(=O)CC1.CCO.OC1CCNCC1.[Pd]>>CC(C)(C)OC(=O)N1CCC(N2CCC(O)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)c1ccccc1C1C=CCC1.[H][H].[Pd]>>COC(=O)c1ccccc1C1CCCC1",
        "output": "143"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)COc2cc(OCc3ccccc3)ccc2O1.CCOC(C)=O.[Pd]>>CC1(C)COc2cc(O)ccc2O1",
        "output": "23"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)C[C@H]1CN(C(=O)/C=C/c2ccccc2)[C@@H](CC(C)C)C(=O)N1.O=C(O)[C@@H]1C[C@H]1c1ccc(F)cc1.O=C1N[C@@H](c2ccccc2)CN[C@H]1c1cccs1>>O=C1N[C@@H](c2ccccc2)CN(C(=O)[C@@H]2C[C@H]2c2ccc(F)cc2)[C@H]1c1cccs1",
        "output": "297"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCC.CO.CSc1ccc(C2=C(c3ccccc3)C(=O)C2(Cl)Cl)cc1.ClCCl.O.O=S([O-])OO.[K+]>>CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)C2(Cl)Cl)cc1",
        "output": "730"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.O=C(CCc1ccc(NC(=O)C(F)(F)F)c([N+](=O)[O-])c1)NC12CC3CC(CC(C3)C1)C2.[Na+].[OH-]>>Nc1ccc(CCC(=O)NC23CC4CC(CC(C4)C2)C3)cc1[N+](=O)[O-]",
        "output": "491"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc(C2CC(C(F)(F)F)n3nc(-c4ccc(C(=O)O)nc4)cc3N2)cc1OC.F[P-](F)(F)(F)(F)F.O>>COc1ccc(C2CC(C(F)(F)F)n3nc(-c4ccc(C(=O)N5CCN(C(=O)OC(C)(C)C)CC5)nc4)cc3N2)cc1OC",
        "output": "605"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCCCc1ccc(CCCn2c(C)ccc2-c2ccc(O[C@H](Cc3ccccc3)C(=O)OCC)cc2)cc1.CO.Cl.[K+].[OH-]>>CCCCCc1ccc(CCCn2c(C)ccc2-c2ccc(O[C@H](Cc3ccccc3)C(=O)O)cc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccccc1.Cl[Cu].O=C=NC12CC3CC(CC(C3)C1)C2.OCCc1cccs1.c1ccncc1>>O=C(NC12CC3CC(CC(C3)C1)C2)OCCc1cccs1",
        "output": "235"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CN(CCOc1ccc(C=C2SC(=O)NC2=O)cc1)c1ncccn1.[H][H].[Pd]>>CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ncccn1",
        "output": "762"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCOc1ccc(S(=O)(=O)C2(C(=O)OCC)CCN(CCCOc3ccccc3)CC2)cc1.CO.[Na+].[OH-]>>CCCCOc1ccc(S(=O)(=O)C2(C(=O)O)CCN(CCCOc3ccccc3)CC2)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(Cl)Cl.CCOC(C)=O.Cn1nc(CO)c2c1C1CCC2C1>>Cn1nc(C=O)c2c1C1CCC2C1",
        "output": "573"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C4(CC#N)CNC4)c3)ncnc21.O=S(=O)(Cl)C1CC1>>C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C4(CC#N)CN(S(=O)(=O)C5CC5)C4)c3)ncnc21",
        "output": "584"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "N#CCC(=O)c1ccccc1.Nc1sc2c(c1C(=O)c1ccc(F)cc1)CCNC2.O=C(Cl)OCc1ccccc1>>Nc1sc2c(c1C(=O)c1ccc(F)cc1)CCN(C(=O)OCc1ccccc1)C2",
        "output": "427"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COc1ccc(C(OCc2cc(CF)cc(CN=[N+]=[N-])c2)(c2ccccc2)c2ccc(OC)cc2)cc1.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(C(OCc2cc(CN)cc(CF)c2)(c2ccccc2)c2ccc(OC)cc2)cc1",
        "output": "562"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(C)=O.CCOC(C)=O.N#Cc1ccc(OCCCCCCl)cc1.[I-].[Na+]>>N#Cc1ccc(OCCCCCI)cc1",
        "output": "97"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)OC(CN=[N+]=[N-])Cc1ccc(Cl)cc1.CP(C)C.O>>CC(C)OC(CN)Cc1ccc(Cl)cc1",
        "output": "89"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.Cn1cc(C(=O)O)c(Nc2ccc(Cl)c(Cl)c2)cc1=O.F[P-](F)(F)(F)(F)F.N.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>Cn1cc(C(N)=O)c(Nc2ccc(Cl)c(Cl)c2)cc1=O",
        "output": "704"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CI.CN(C)C=O.O.O=Cc1ccc(C(F)(F)F)cc1O.[H-].[Na+]>>COc1cc(C(F)(F)F)ccc1C=O",
        "output": "62"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCNC(=O)c1nnc(-c2cc(C(C)C)c(O)cc2O)n1-c1ccc(CN2CCC(C(=O)O)CC2)cc1.CCOC(C)=O.CCc1c2c(nc3ccc(O)cc13)-c1cc3c(c(=O)n1C2)COC(=O)C3(CC)OC(=O)C1CCNCC1.CN(C)C=O.ClCCCl.On1nnc2ccccc21.[Cl-].[NH4+]>>CCNC(=O)c1nnc(-c2cc(C(C)C)c(O)cc2O)n1-c1ccc(CN2CCC(C(=O)N3CCC(C(=O)OC4(CC)C(=O)OCc5c4cc4n(c5=O)Cc5c-4nc4ccc(O)cc4c5CC)CC3)CC2)cc1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.CO.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O=C(Cc1ccccc1)N1CCC(Cn2ccc3nc(-c4cnn(C5CCCCO5)c4)ccc32)CC1>>O=C(Cc1ccccc1)N1CCC(Cn2ccc3nc(-c4cn[nH]c4)ccc32)CC1",
        "output": "689"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COCCOC.O=C([O-])[O-].O=c1ncc(Br)cn1CCO.OB(O)c1ccccc1.[Na+].[Na+]>>O=c1ncc(-c2ccccc2)cn1CCO",
        "output": "871"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cnc(CCCN2C(=O)c3ccccc3C2=O)nc1Nc1cccc(C)c1.Cl.[Na+].[OH-]>>Cc1cccc(Nc2nc(CCCN3C(=O)c4ccccc4C3=O)ncc2C(=O)O)c1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)n1cccn1.ClCCl.O=C1CCC(=O)N1Br>>CC(C)(C)n1cc(Br)cn1",
        "output": "620"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O=C(O)CCc1ccccc1C(F)(F)F.O=C1NC2(CCNCC2)c2c(Cl)cc(Cl)cc21>>O=C1NC2(CCN(C(=O)CCc3ccccc3C(F)(F)F)CC2)c2c(Cl)cc(Cl)cc21",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCCN1CCN(c2nc(C)c(C(=O)O)s2)C1=O.Cc1nc(N2C[C@H](C)N(Cc3ccc(F)cc3)C2=O)sc1C(=O)O.NCc1cccnc1>>C=CCCN1CCN(c2nc(C)c(C(=O)NCc3cccnc3)s2)C1=O",
        "output": "534"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.CCO.CN(C)CCN1CCN(C(=O)Nc2cc(Oc3ccc(N)cc3F)ncn2)CC1.Cc1ccccc1.O=C(Cc1ccc(F)cc1)N=C=S>>CN(C)CCN1CCN(C(=O)Nc2cc(Oc3ccc(NC(=S)NC(=O)Cc4ccc(F)cc4)cc3F)ncn2)CC1",
        "output": "961"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1cccc(-c2ccccc2)c1.CN(C)C=O.[C-]#N.[Na+]>>N#CCc1cccc(-c2ccccc2)c1",
        "output": "39"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CN)c1.Fc1cnc(Cl)nc1>>Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ncc(F)cn2)c1",
        "output": "544"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)CNCc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1.CO.Cl.Cl.N>>COc1cc(C)cc2cc(-c3c(CNCC(N)=O)cn4ncnc(N)c34)sc12",
        "output": "163"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.CS(=O)(=O)N1CCC(C(=O)O)CC1.ClCCl.Nc1ccc2[nH]ncc2c1.O=C(Cl)C(=O)Cl.O=C([O-])O.[Na+]>>CS(=O)(=O)N1CCC(C(=O)Nc2ccc3[nH]ncc3c2)CC1",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCC(O)(CO)c1cncc(OCC#Cc2ccccc2)c1>>CCC1(c2cncc(OCC#Cc3ccccc3)c2)COC(C)(C)O1",
        "output": "265"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CN(C)CCCCCCCCCCCN1C(=O)c2ccccc2C1=O.Cl.NN.O>>CN(C)CCCCCCCCCCCN",
        "output": "242"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(OCCO)C(OC)C3)C(C)C(O[Si](C)(C)C(C)(C)C)CC1=O)C(C)CC2OC.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(OCCOS(C)(=O)=O)C(OC)C3)C(C)C(O[Si](C)(C)C(C)(C)C)CC1=O)C(C)CC2OC",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(-c2ccc(C(F)(F)F)cc2)ccc1C(=O)O.Nc1ccc(Cl)c(-c2nc3cnccc3[nH]2)c1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)ccc1C(=O)Nc1ccc(Cl)c(-c2nc3cnccc3[nH]2)c1",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)Cl.C[C@H]1COCCN1c1nc(Cl)nc2c1CNC2.Cl.O=C([O-])O.[Na+]>>CCOC(=O)N1Cc2nc(Cl)nc(N3CCOC[C@@H]3C)c2C1",
        "output": "219"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.COc1cncc(-c2cccc3[nH]c4ccccc4c23)c1.N#Cc1ccc(Br)cc1F.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2]>>COc1cncc(-c2cccc3c2c2ccccc2n3-c2ccc(C#N)c(F)c2)c1",
        "output": "349"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)O.CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2cn(C(=O)c3c(Cl)cccc3Cl)c3ncc(Br)cc23)c1F.CCOC(C)=O.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccc2[nH]ccc2c1.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2cn(C(=O)c3c(Cl)cccc3Cl)c3ncc(-c4ccc5[nH]ccc5c4)cc23)c1F",
        "output": "833"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cccc(Oc2c(NS(=O)(=O)c3ccc(SC)cc3)cc(C(=O)O)cc2OCC(O)CO)c1.Nc1ccccc1>>COc1cccc(Oc2c(NS(=O)(=O)c3ccc(SC)cc3)cc(C(=O)Nc3ccccc3)cc2OCC(O)CO)c1",
        "output": "50"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1ccc2nc(S(C)(=O)=O)ccc2c1Sc1ccc(F)cc1.[Cl-].[Li+]>>CS(=O)(=O)c1ccc2c(Sc3ccc(F)cc3)c(O)ccc2n1",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(CCN)CC1.O=C(O)CNC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)N1CCC(CCNC(=O)CNC(=O)OCc2ccccc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C(=O)c1cc2cnc(Nc3ccc(C4CCNCC4)cn3)nc2n1C1CCCC1.OCCBr>>CN(C)C(=O)c1cc2cnc(Nc3ccc(C4CCN(CCO)CC4)cn3)nc2n1C1CCCC1",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCCC.COC(C)(C)C.COCCC(C#N)(CCOC)C(=O)OC.[Na+].[OH-]>>COCCC(C#N)(CCOC)C(=O)O",
        "output": "361"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C(C)(C)c1ccc(-c2ccc(C(F)(F)F)cn2)cc1.CCOC(=O)C(C)(C)c1ccc(Br)cc1>>CC(C)(C(=O)O)c1ccc(-c2ccc(C(F)(F)F)cn2)cc1",
        "output": "615"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#Cc1ccc2c(c1)/C(=C/c1ccc[nH]1)C(=O)N2.C1CCOC1.CCO.COc1cc[nH]c1/C=C1\\C(=O)Nc2ccc(C#C[Si](C)(C)C)cc21.O.O=[N+]([O-])[O-].[Ag+].[C-]#N.[K+]>>C#Cc1ccc2c(c1)/C(=C/c1[nH]ccc1OC)C(=O)N2",
        "output": "337"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1CCCCN1CCN(c2cccc(F)n2)CC1>>NCCCCN1CCN(c2cccc(F)n2)CC1",
        "output": "242"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)Oc1ccc(N=c2[nH]c(=O)n(CC3(CO[Si](c4ccccc4)(c4ccccc4)C(C)(C)C)COC3)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl.CCCC[N+](CCCC)(CCCC)CCCC.[Cl-].[F-].[NH4+]>>CC(C)Oc1ccc(N=c2[nH]c(=O)n(CC3(CO)COC3)c(=O)n2Cc2ccc(Cl)cc2)cc1Cl",
        "output": "781"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CI.CN(C)C=O.NC(=O)c1n[nH]cc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>Cn1cc([N+](=O)[O-])c(C(N)=O)n1",
        "output": "229"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)C[AlH]CC(C)C.CCO.COc1ccc(C2(CCO)CCCc3cc(OC)ccc3C2)cc1.Cc1ccccc1.Cl>>OCCC1(c2ccc(O)cc2)CCCc2cc(O)ccc2C1",
        "output": "20"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(Oc2ccc(C=O)cc2)nc1.CCOC(C)=O.CO.Cl.[Na+].[OH-]>>O=Cc1ccc(Oc2ccc(C(=O)O)cn2)cc1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(c1ccc(Br)cc1Cl)C(O)(c1ccc2c(c1)N(C)C(=O)CO2)C(F)(F)F.N#Cc1cc(B(O)O)ccc1F>>CC(c1ccc(-c2ccc(F)c(C#N)c2)cc1Cl)C(O)(c1ccc2c(c1)N(C)C(=O)CO2)C(F)(F)F",
        "output": "837"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.CC(C(=O)O)c1ccc(O)cc1.CCO.[Na+].[OH-]>>CC(C(=O)O)c1ccc(OCc2ccccc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCOC(=O)C(Br)CC.N#Cc1ccc(O)cc1.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C(CC)Oc1ccc(C#N)cc1",
        "output": "455"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C1CCNC(=O)C1.CCOC(C)=O.COc1ccnc2c1ccc1c(OC)ccnc12.CS(C)=O.Ic1ccccc1.O=C([O-])[O-].[Cu]I.[K+].[K+]>>CCOC(=O)C1CCN(c2ccccc2)C(=O)C1",
        "output": "921"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COCCOC.COc1cccc(B(O)O)c1F.Cc1c(Br)c(=O)n(C[C@H](NC(=O)OC(C)(C)C)C2CCCCC2)c(=O)n1Cc1c(F)cccc1F.[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccccc1>>COc1cccc(-c2c(C)n(Cc3c(F)cccc3F)c(=O)n(C[C@H](NC(=O)OC(C)(C)C)C3CCCCC3)c2=O)c1F",
        "output": "871"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.Cl.ClC(Cl)Cl.N#CCC1CCNC1.O=S(=O)(Cl)c1ccc(Cl)cc1>>N#CCC1CCN(S(=O)(=O)c2ccc(Cl)cc2)C1",
        "output": "99"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)CCN.CN(C)CCn1ccc2c(N3CCOCC3)nc(-c3ccc(N)cc3)nc21.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CN(C)CCNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3ccn(CCN(C)C)c3n2)cc1",
        "output": "914"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](CNC(=O)c2cc(-c3ccc(CN)cc3)nc3ccccc23)CC1.CCN(C(C)C)C(C)C.CN(C)c1ccncc1.ClCCl>>CC(=O)NCc1ccc(-c2cc(C(=O)NC[C@@H]3CC[C@@H](CNC(=O)OC(C)(C)C)CC3)c3ccccc3n2)cc1",
        "output": "515"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.O=C(O)CC(CC(=O)O)c1ccc2oc3c(c2c1)CCCC3>>O=C1CC(c2ccc3oc4c(c3c2)CCCC4)CC(=O)O1",
        "output": "436"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(C)=O.FC(F)(F)c1cn[nH]c1.O.O=C(O)[C@@H]1C[C@@H](O)CN1.O=C([O-])[O-].OCc1ccc(I)cc1.[Cs+].[Cs+].[Cu]I>>OCc1ccc(-n2cc(C(F)(F)F)cn2)cc1",
        "output": "901"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1ccc(Br)cc1Br.O=C(Cl)c1ccc(F)cc1.c1ccncc1>>O=C(Nc1ccc(Br)cc1Br)c1ccc(F)cc1",
        "output": "11"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCOCC.ClCCCBr.O.[Na+].[OH-].c1ccc2nc(N3CCNCC3)ccc2c1>>ClCCCN1CCN(c2ccc3ccccc3n2)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.O=C(O)[C@@H]1CC(O)CN1C(=O)OCc1ccccc1.O=S(=O)(O)O.O=[Cr](=O)(O)O>>O=C1C[C@@H](C(=O)O)N(C(=O)OCc2ccccc2)C1",
        "output": "650"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCc1c(O)ccc2oc(Cc3ccc(OC)cc3)c(C)c12.CCS.CN(C)C=O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[H-].[Na+]>>CCCc1c(O)ccc2oc(Cc3ccc(O)cc3)c(C)c12",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCCC1=O.O=C=NC1CCCCC1.c1ccc2ncc(Nc3ncnc4c3CNC4)cc2c1>>O=C(NC1CCCCC1)N1Cc2ncnc(Nc3cnc4ccccc4c3)c2C1",
        "output": "437"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCOCC1.COC(=O)c1cn(C(=O)OC(C)(C)C)c2nccc(CNC3(C(=O)O)CCCC3)c12.F[P-](F)(F)(F)(F)F.NC1CCCC1>>COC(=O)c1cn(C(=O)OC(C)(C)C)c2nccc(CNC3(C(=O)NC4CCCC4)CCCC3)c12",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)COc1ccc(SCc2ccc(OCc3ccc(F)c(C(F)(F)F)c3)cc2)c2c1CCC2.[Br-].[K+]>>O=C(O)COc1ccc(SCc2ccc(OCc3ccc(F)c(C(F)(F)F)c3)cc2)c2c1CCC2",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.Fc1ccccc1.O.O=C(Cl)c1ccc(Br)cc1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(c1ccc(F)cc1)c1ccc(Br)cc1",
        "output": "61"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CCOCC.CN(C)C=O.COc1ccc(O)cc1.Cl.ClCCc1c[nH]cn1.[H-].[I-].[Na+]>>COc1ccc(OCCc2c[nH]cn2)cc1",
        "output": "74"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)c1cc(C(=O)c2ccc(C(F)(F)F)nc2)nn1-c1ncccc1Cl.[Na+].[OH-]>>O=C(c1ccc(C(F)(F)F)nc1)c1cc(C(=O)O)n(-c2ncccc2Cl)n1",
        "output": "152"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCOCCOCCOCCOCCO1.CCC(CC)CN.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1cc(Cl)ccc1Cl.[K+].[K+]>>CCC(CC)CNc1ccc(Cl)cc1[N+](=O)[O-]",
        "output": "304"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c2s1.CON.Cl.Cl.ClC(Cl)Cl.O.c1ccncc1>>CCc1cc2c(=O)n(CC(=NOC)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c2s1",
        "output": "212"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(C)c1cccc(N)c1.O=Cc1cnn2ccc(Cl)nc12>>CC(C)(C)c1cccc(Nc2ccn3ncc(C=O)c3n2)c1",
        "output": "161"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCC(CC)CBr.COCCO.Oc1ccc(Br)cc1.[Na+].[OH-]>>CCCCC(CC)COc1ccc(Br)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.O.O=[N+]([O-])c1ccc(Nc2ccccc2)cc1.[Cl-].[NH4+].[Zn]>>Nc1ccc(Nc2ccccc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CC(C)(C)[O-].CCOC(C)=O.NCc1cc(F)cc(F)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=c1[nH]nc(Cl)c2cc(Br)ccc12.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>O=c1[nH]nc(Cl)c2cc(NCc3cc(F)cc(F)c3)ccc12",
        "output": "932"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCCC[C@@H]1C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1ccc(N)c([N+](=O)[O-])c1>>CC(C)(C)OC(=O)N1CCCC[C@@H]1C(=O)Nc1ccc(N)c([N+](=O)[O-])c1",
        "output": "563"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CN(C)C=O.Cc1cc(Cl)ncc1[N+](=O)[O-].FC1(F)CNC1.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1cc(N2CC(F)(F)C2)ncc1[N+](=O)[O-]",
        "output": "220"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)S.CCc1cc([N+](=O)[O-])c(Cl)nc1C.CN(C)C=O.[H-].[Na+]>>CCc1cc([N+](=O)[O-])c(SC(C)(C)C)nc1C",
        "output": "333"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.COc1cc(-c2cccc(F)c2)c(F)cc1-n1c(=O)ccc2cc(SCc3ccccc3)ccc21>>O=c1ccc2cc(SCc3ccccc3)ccc2n1-c1cc(F)c(-c2cccc(F)c2)cc1O",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCCC(Cn2ncc3cnc(Cl)nc32)C1.ClCCl.O=C(O)C(F)(F)F>>Clc1ncc2cnn(CC3CCCNC3)c2n1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(Cc1ccc(F)cc1)NCC(O)c1cc(OCc2ccccc2)cc2c1OC(C)(C)C(=O)N2.CO.[Pd]>>CC(C)(Cc1ccc(F)cc1)NCC(O)c1cc(O)cc2c1OC(C)(C)C(=O)N2",
        "output": "23"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(C)Sc1cc(C(F)(F)F)ccc1C#N.CCO.O.[Na+].[OH-]>>CCC(C)Sc1cc(C(F)(F)F)ccc1C(=O)O",
        "output": "445"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cl[Sn]Cl.O=[N+]([O-])c1cc(Br)cnc1Cl>>Nc1cc(Br)cnc1Cl",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Nc1ccc2c(cnn2CCN2CCCC2)c1.O=C(O)Cc1ccc(Oc2ccccc2)cc1>>O=C(Cc1ccc(Oc2ccccc2)cc1)Nc1ccc2c(cnn2CCN2CCCC2)c1",
        "output": "365"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)[C@@H](N)CC(C)C.Cl.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(-c2ccc(O)cc2)cc1>>COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(-c2ccc(O)cc2)cc1",
        "output": "652"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.Cc1cc(C(=O)CN2C(=O)C(c3ccc(Cl)cc3)=NC23CCN(C(=O)OC(C)(C)C)CC3)ccc1Cl.Cl>>Cc1cc(C(=O)CN2C(=O)C(c3ccc(Cl)cc3)=NC23CCNCC3)ccc1Cl",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1c(F)cccc1-c1cnc(C#N)c(F)c1.N.[Ni]>>COC(=O)c1c(F)cccc1-c1cnc(CN)c(F)c1",
        "output": "205"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CCC(=O)OCC1CCN(C(=O)OCc2ccccc2)CC1.[Pd]>>Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CCC(=O)OCC1CCNCC1",
        "output": "428"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.CSc1ccc(/C(=C\\C2CCOCC2)c2[nH]c(-c3ccccn3)nc2Cl)cc1Cl.O.O=C([O-])O.O=S([O-])OO.[K+].[Na+]>>CS(=O)(=O)c1ccc(/C(=C\\C2CCOCC2)c2[nH]c(-c3ccccn3)nc2Cl)cc1Cl",
        "output": "730"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.ClCCl.Fc1cc(Br)ccc1OC(F)F.[K+]>>CC1(C)OB(c2ccc(OC(F)F)c(F)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1ccc(CCCCCO)cc1.ClCCl>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1ccc(CCCCC=O)cc1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCN.CCN(CC)CC.CCN(CC)CCCNc1nc(-c2cccc(C(=O)O)c2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F>>CCCNC(=O)c1cccc(-c2nc(NCCCN(CC)CC)nc3c2ccc(=O)n3-c2c(F)cccc2F)c1C",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Cc1ccc2cc(C#N)ccc2n1.N.[Ni]>>Cc1ccc2cc(CN)ccc2n1",
        "output": "175"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCCN(C(=O)c2cc(Cc3n[nH]c(=O)c4c3CCCC4)ccc2F)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCCNCC1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)c1ccc2c(c1)CCc1ccc(C(=O)O)cc1S2(=O)=O.O=C(O)c1ccc2c(c1)S(=O)(=O)c1ccccc1C=C2>>CC(=O)c1ccc2c(c1)CCc1ccc(CO)cc1S2(=O)=O",
        "output": "72"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(CC(=O)OC(C)(C)C)ccc1NC(=O)Nc1ccccc1F.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(CC(=O)O)ccc1NC(=O)Nc1ccccc1F",
        "output": "278"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.Nc1ccc2c(c1)C1CCC2CN(C(=O)C(F)(F)F)C1.O.O=N[O-].[Na+]>>O=C(N1CC2CCC(C1)c1cc(Br)ccc12)C(F)(F)F",
        "output": "373"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(O)c1cccc(N(C)C)c1.CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)OC(C)c4cccc(N(C)C)c4)c(C)c3C)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.Cc1c(Br)cccc1-n1c(=O)ccn(-c2ccc(F)cc2)c1=O.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1c(B2OC(C)(C)C(C)(C)O2)cccc1-n1c(=O)ccn(-c2ccc(F)cc2)c1=O",
        "output": "942"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1c(OCCCOc2ccc(Cl)c3ccccc23)ccc2c1OC(CCC(=O)OCC)(CCC(=O)OCC)CC2=O.CCCc1c(OCCCOc2ccc(Cl)cc2)ccc2c1OC(CCC(=O)OCC)(CCC(=O)OCC)CC2=O.CCOCC>>CCCc1c(OCCCOc2ccc(Cl)c3ccccc23)ccc2c1OC(CCC(=O)O)(CCC(=O)O)CC2=O",
        "output": "255"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)C(C)CN(CC(F)(F)F)c1ccc(C#N)c(C(F)(F)F)c1.[Na+].[OH-]>>CC(CN(CC(F)(F)F)c1ccc(C#N)c(C(F)(F)F)c1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)NC1c2ccsc2CC1O.ClC(Cl)Cl.O=C(O)C(F)(F)F>>NC(Cc1ccccc1)C(=O)NC1c2ccsc2CC1O",
        "output": "431"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C1COCCO1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc(C2CCCCO2)c2sc(N)nc12.F[P-](F)(F)(F)(F)F.O=C(O)c1ccnc(Br)c1.O=C([O-])O.[Na+]>>COc1ccc(C2CCCCO2)c2sc(NC(=O)c3ccnc(Br)c3)nc12",
        "output": "918"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCCCCCCC=CCCCCCCCC(=O)NCCO.N#N.[Al+3].[H-].[H-].[H-].[H-].[K+].[Li+].[OH-]>>CCCCCCCCC=CCCCCCCCCNCCO",
        "output": "112"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCn1c(COCC)nc2cnc3ccc(OCc4ccccc4)cc3c21.Cc1ccc(S(=O)(=O)Cl)cc1.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.[NH4+].[OH-]>>CCCn1c(COCC)nc2c(N)nc3ccc(OCc4ccccc4)cc3c21",
        "output": "959"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(-c3ccc(-c4nc(C(F)(F)F)cn4-c4cc(Cl)ccc4Cl)s3)cn2)CC1.ClCCl.O=C(O)CC(F)(F)F>>FC(F)(F)c1cn(-c2cc(Cl)ccc2Cl)c(-c2ccc(-c3ccc(N4CCNCC4)nc3)s2)n1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N(C)CCOc1cccc2ncnc(Nc3ccc(O)c(C)c3)c12.ClCc1ccccn1>>CC(=O)N(C)CCOc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(C)c3)c12",
        "output": "616"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.Cc1cc(N)c2[nH]c(-c3ccccn3)cc2c1.ClCCl.O.O=C(Cl)c1ccccc1>>Cc1cc(NC(=O)c2ccccc2)c2[nH]c(-c3ccccn3)cc2c1",
        "output": "501"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)c1ccc(C(=O)O)cc1[N+](=O)[O-].CC(C)O.ClCCl.N.O=C([O-])O.Oc1cccc2[nH]nnc12.[Na+]>>CC(C)(C)c1ccc(C(N)=O)cc1[N+](=O)[O-]",
        "output": "358"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CO.OCC(CCc1ccccc1)NCC(O)c1cc(-c2ccc(Cl)cc2)nn1-c1ncccn1>>CC(C)(C)OC(=O)N(CC(O)c1cc(-c2ccc(Cl)cc2)nn1-c1ncccn1)C(CO)CCc1ccccc1",
        "output": "694"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.ClCCl.Clc1nc(Cl)c2cc(Br)ccc2n1>>Clc1nc(N2CCOCC2)c2cc(Br)ccc2n1",
        "output": "296"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.ClCCl.O=P(O)(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.Oc1ccc2ccccc2c1>>CC(=O)Oc1ccc2ccccc2c1",
        "output": "46"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCOC(=O)c1ncccc1NCCOC.O=C1CCC(=O)N1Br>>CCOC(=O)c1nc(Br)ccc1NCCOC",
        "output": "779"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)c1ccc(Cl)c(C(=O)O)c1.Cc1cnc2c(C(F)(F)F)cccc2c1-c1cccc(O)c1>>Cc1cnc2c(C(F)(F)F)cccc2c1-c1cccc(OC(=O)c2cc(S(C)(=O)=O)ccc2Cl)c1",
        "output": "355"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.C1CCOC1.CC(C)(C)OC(=O)N1CC(F)CC1C(=O)O>>CC(C)(C)OC(=O)N1CC(F)CC1CO",
        "output": "218"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1cc(Br)ccc1O.N#N.[K+]>>Cc1cc(B2OC(C)(C)C(C)(C)O2)ccc1O",
        "output": "942"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.Cc1ccc(N)cc1.Cc1cccc(NC(=O)OC(C)(C)C)c1C(=O)O.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+]>>Cc1ccc(NC(=O)c2c(C)cccc2NC(=O)OC(C)(C)C)cc1",
        "output": "50"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#CC1(O)CCCC1O.NC(=O)c1cc2n(n1)-c1cc(I)ccc1OCC2>>NC(=O)c1cc2n(n1)-c1cc(C#CC3(O)CCCC3O)ccc1OCC2",
        "output": "664"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=C[C@@H]1C[C@]1(NC(=O)OC(C)(C)C)C(=O)NS(=O)(=O)C1CC1.[Ru]>>CC[C@@H]1C[C@]1(NC(=O)OC(C)(C)C)C(=O)NS(=O)(=O)C1CC1",
        "output": "116"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1c2ccccc2CCC1CC(=O)OCc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>O=C(CC1CCc2ccccc2N1)OCc1ccccc1",
        "output": "830"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.COc1cc2c(O)ccnc2cc1OCc1ccccc1.Cc1ccccc1.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>COc1cc2c(Cl)ccnc2cc1OCc1ccccc1",
        "output": "177"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CCO.CCOC(=O)c1ccc([N+](=O)[O-])c(NC(=O)CCCC(C)C)c1>>CCOC(=O)c1ccc(N)c(NC(=O)CCCC(C)C)c1",
        "output": "772"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1ncnc2c1c(-c1cc(OCC3CCCO3)ccc1F)cn2[C@H]1CC[C@@H](N)CC1>>CC(=O)N[C@H]1CC[C@@H](n2cc(-c3cc(OCC4CCCO4)ccc3F)c3c(N)ncnc32)CC1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[O-].N#N.O.O=Cc1c2ccccc2c(Cl)c2ccccc12.OCCO.[K+]>>O=Cc1c2ccccc2c(OCCO)c2ccccc12",
        "output": "57"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1ccc(F)cn1.O=C(Cl)c1ccc(F)c([N+](=O)[O-])c1>>O=C(Nc1ccc(F)cn1)c1ccc(F)c([N+](=O)[O-])c1",
        "output": "463"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cn(CCOC2CCCCO2)nc1-c1cn(C(C)C)c2cc(Nc3ccnc(-c4cnn(S(=O)(=O)C5CC5)c4)n3)ncc12.Cl.O=C([O-])O.[Na+]>>Cc1cn(CCO)nc1-c1cn(C(C)C)c2cc(Nc3ccnc(-c4cnn(S(=O)(=O)C5CC5)c4)n3)ncc12",
        "output": "543"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.COC(=O)C1CN(Cc2ccc(-c3noc(-c4ccc(CC(C)C)c(C)c4)n3)c(C)n2)C1.O=C(O)C(=O)O.[Na+].[OH-]>>Cc1cc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)nc3C)no2)ccc1CC(C)C",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)C(C)(C)CNC(=O)c1nc(C#N)c2c(cc(-c3ccccc3)c(=O)n2Cc2ccccc2)c1O.Cl.[Na+].[OH-]>>CC(C)(CNC(=O)c1nc(C#N)c2c(cc(-c3ccccc3)c(=O)n2Cc2ccccc2)c1O)C(=O)O",
        "output": "361"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc2c(Br)cccc2c1CN1C(=O)[C@@H](N)CNc2ccccc21.C[C@@H](C(=O)O)N(C)C(=O)OC(C)(C)C.F[P-](F)(F)(F)(F)F.O.O=C(O)C(F)(F)F>>COc1ccc2c(Br)cccc2c1CN1C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)CNc2ccccc21",
        "output": "133"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.OCCCCCCBr>>CC(C)(C)[Si](C)(C)OCCCCCCBr",
        "output": "193"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C(N)=O)C(NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(C3CC3)nc12)C1CC1.ClCCl.O=C(O)C(F)(F)F>>CC(C)(C(N)=O)C(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C1CC1",
        "output": "981"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CO.Nc1[nH]nc(O)c1-c1ccccn1.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)OC(=O)n1nc(O)c(-c2ccccn2)c1N",
        "output": "841"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)c1ccc(-c2nc(Cl)c3c(C)csc3n2)cc1.NCc1ccc(Cl)c(Cl)c1>>COC(=O)c1ccc(-c2nc(NCc3ccc(Cl)c(Cl)c3)c3c(C)csc3n2)cc1",
        "output": "906"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=CC(=O)N1CC(CNc2nc(Cl)nc3ccoc23)C1.CC(C)O.Cn1cc(N)cn1.O=C(O)C(F)(F)F.[Na+].[OH-]>>C=CC(=O)N1CC(CNc2nc(Nc3cnn(C)c3)nc3ccoc23)C1",
        "output": "992"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CSc1cccc(Oc2ncc(F)cc2C(=O)O)c1.Cc1ncccc1N.Cl.On1nnc2ccccc21>>CSc1cccc(Oc2ncc(F)cc2C(=O)Nc2cccnc2C)c1",
        "output": "863"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1cncc(C(F)F)c1.CCO.CCOC(C)=O.Cl>>Nc1cncc(C(F)F)c1",
        "output": "877"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCc1cc(C(=O)NCc2cccc(O)c2)sc1C(=O)OC.Cl.O.O.[Li+].[OH-]>>CCc1cc(C(=O)NCc2cccc(O)c2)sc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O=C(O)C=Cc1ccccc1.O=S(=O)(O)O>>COC(=O)C=Cc1ccccc1",
        "output": "174"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)O)cc3)c(Cl)cc21.CCOC(C)=O.CN(C)C=O.ClCCCl.Nc1ccc(Cl)nn1.O=C(Cl)C(=O)Cl.c1ccncc1>>CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)Nc4ccc(Cl)nn4)cc3)c(Cl)cc21",
        "output": "917"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.Cl.O=C(NCCNC(=O)C1CCNCC1)c1cn(-c2ccccc2)nc1C(F)(F)F.O=C=Nc1ccccc1>>O=C(NCCNC(=O)C1CCN(C(=O)Nc2ccccc2)CC1)c1cn(-c2ccccc2)nc1C(F)(F)F",
        "output": "323"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N1CCC(C(=O)Cl)CC1.CC(C)=O.CCN(CC)CC.Cl.NS(=O)(=O)c1ccc(S(=O)(=O)c2ccc(O)cc2)s1>>CC(=O)N1CCC(C(=O)Oc2ccc(S(=O)(=O)c3ccc(S(N)(=O)=O)s3)cc2)CC1",
        "output": "111"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(O)c1ccc(C2(CN)CCC(F)(F)CC2)cn1.O=C(O)c1cccc(Cl)c1Cl>>CC(C)(O)c1ccc(C2(CNC(=O)c3cccc(Cl)c3Cl)CCC(F)(F)CC2)cn1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1cccc2nc(C(C)C)n(CC(OC)OC)c12.ClCCl.O.O=C(O)C(F)(F)F>>COC(=O)c1cccc2nc(C(C)C)n(CC=O)c12",
        "output": "234"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C1CCCCc2c(OCC(=O)OC(C)(C)C)cccc21)S(=O)(=O)c1ccc(-c2ccccc2)cc1.[Na+].[OH-]>>CN(C1CCCCc2c(OCC(=O)O)cccc21)S(=O)(=O)c1ccc(-c2ccccc2)cc1",
        "output": "278"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN=C=O.Cl.FC(F)(F)c1ccc(CO[C@H]2CCNC[C@H]2C(c2ccccc2)c2ccccc2)cc1>>CNC(=O)N1CC[C@H](OCc2ccc(C(F)(F)F)cc2)[C@H](C(c2ccccc2)c2ccccc2)C1",
        "output": "437"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.CC#N.CC(O)(C(=O)O)C(F)(F)F.CCN(C(C)C)C(C)C>>CC(O)(C(=O)OCc1ccccc1)C(F)(F)F",
        "output": "403"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)OCc1c(-c2cc(Nc3cnc(N4CCN(C5COC5)C[C@@H]4C)cn3)c(=O)n(C)c2)ccnc1N1CCn2c(cc3c2CCCC3)C1=O.CC(C)O.O.[Li+].[OH-]>>C[C@H]1CN(C2COC2)CCN1c1cnc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CCCC6)C4=O)c3CO)cn(C)c2=O)cn1",
        "output": "348"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(C2CC2)cnc1Nc1ccc2c(c1)c(-c1cccc(C#N)c1)cn2C.[Na+].[OH-]>>Cn1cc(-c2cccc(C#N)c2)c2cc(Nc3ncc(C4CC4)cc3C(=O)O)ccc21",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.C1COCCN1.CCOC(C)=O.Cc1ccccc1.Nc1ncnn2c(C(=O)CBr)cc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12>>Nc1ncnn2c(C(=O)CN3CCOCC3)cc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12",
        "output": "413"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCC(O)CC.CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.[Na+]>>CCCC(CC)OC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(C)c1C",
        "output": "960"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1ccc2c(Oc3ccc(O)cc3)c(-c3ccccc3)c(C)cc2c1.O=C([O-])[O-].OCCOCCCl.[Cs+].[Cs+]>>COc1ccc2c(Oc3ccc(OCCOCCO)cc3)c(-c3ccccc3)c(C)cc2c1",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cccc(C(=O)CBr)c1.Nc1cc(N2CCC2)ccn1>>COc1cccc(-c2cn3ccc(N4CCC4)cc3n2)c1",
        "output": "508"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCO.COC(=O)c1cccc2cc(Oc3c(Cl)cc([N+](=O)[O-])cc3Cl)cnc12.O.[Cl-].[Fe].[NH4+]>>COC(=O)c1cccc2cc(Oc3c(Cl)cc(N)cc3Cl)cnc12",
        "output": "335"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C/C(=N\\OCCCc1cccc(C(O)C(C)C)n1)c1cccc(C)n1.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.O=C([O-])O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>C/C(=N\\OCCCc1cccc(C(=O)C(C)C)n1)c1cccc(C)n1",
        "output": "456"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21>>CC(=O)NC1CCc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc21",
        "output": "206"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Cn1ncc2[nH]c3ccc(Cc4cccc([N+](=O)[O-])c4)cc3c(=O)c21.O.[Cl-].[Fe].[NH4+]>>Cn1ncc2[nH]c3ccc(Cc4cccc(N)c4)cc3c(=O)c21",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C[C@@H]1NC[C@@H](c2ccccc2)CNC1=O.CC(C)C[C@H]1CN(C(=O)/C=C/c2ccccc2)[C@@H](CC(C)C)C(=O)N1.O=C(O)[C@@H]1C[C@H]1c1ccccc1>>CC(C)C[C@H]1C(=O)NC[C@H](c2ccccc2)CN1C(=O)[C@@H]1C[C@H]1c1ccccc1",
        "output": "297"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCN([C@H]1COc2c(F)ccc(O)c2C1)C(C)(C)C.Cc1cc(C)nc(C)c1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCCN([C@H]1COc2c(F)ccc(OS(=O)(=O)C(F)(F)F)c2C1)C(C)(C)C",
        "output": "731"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1nc2cc(S(=O)(=O)Cl)ccc2n1CC1CCOCC1.CCN(C(C)C)C(C)C.CN(C)C=O.Cl.O=C(O)CC1CNC1>>CC(C)(C)c1nc2cc(S(=O)(=O)N3CC(CC(=O)O)C3)ccc2n1CC1CCOCC1",
        "output": "99"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COCCNc1cnc2c(-c3ccc(C(=O)OC)cc3F)nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1.O.O.[Li]O>>COCCNc1cnc2c(-c3ccc(C(=O)O)cc3F)nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C(Cl)c1ccccc1.O=C(OCC(Cl)(Cl)Cl)N1CCC(c2cccc(OCCO)c2)C(OCc2ccc3ccccc3c2)C1>>O=C(OCCOc1cccc(C2CCN(C(=O)OCC(Cl)(Cl)Cl)CC2OCc2ccc3ccccc3c2)c1)c1ccccc1",
        "output": "51"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCOC(=O)c1nc(-c2ccc(C)cc2)c2ccccc2c1OCc1ccccc1.CCOC(C)=O>>CCCCOC(=O)c1nc(-c2ccc(C)cc2)c2ccccc2c1O",
        "output": "264"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.CC(=O)O.CCOCC.Cc1csc([C@H]2CCCN2C(=O)OCc2ccccc2)n1>>Cc1csc([C@H]2CCCN2)n1",
        "output": "428"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCCc1cc(Cl)ccc1Br>>CS(=O)(=O)OCCc1cc(Cl)ccc1Br",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC1(CCOCc2ccccc2)CC1.CCO.[H][H].[OH-].[OH-].[Pd+2]>>CC(C)(C)OC(=O)NC1(CCO)CC1",
        "output": "178"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.CN(CCC(=O)O)C(=O)OC(C)(C)C.CO.ClCCl>>COC(=O)CCN(C)C(=O)OC(C)(C)C",
        "output": "195"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.Cl.ClCCl.Cn1c(=O)c(CN(CC(c2ccccc2)C2CCN(C(=O)OC(C)(C)C)CC2)C(=O)C2CCCCC2)cc2ccccc21>>Cn1c(=O)c(CN(CC(c2ccccc2)C2CCNCC2)C(=O)C2CCCCC2)cc2ccccc21",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC1(C)CCNc2ccccc21.O.O=C([O-])O.O=S(=O)(Cl)c1cc(Br)c(Cl)cc1F.[Na+]>>CC1(C)CCN(S(=O)(=O)c2cc(Br)c(Cl)cc2F)c2ccccc21",
        "output": "791"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-n2cccn2)cc1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Cl>>CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c(Cl)c2-n2cccn2)cc1",
        "output": "121"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COC(=O)C(N)Cc1ccc(Br)cc1.Cl.F[P-](F)(F)(F)(F)F.Nc1ccc(Cl)cc1C(=O)O>>COC(=O)C(Cc1ccc(Br)cc1)NC(=O)c1cc(Cl)ccc1N",
        "output": "652"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)CN1Cc2c(cc(Cl)c3[nH]ncc23)C[C@@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O.O=C(O)C[C@@H]1Cc2ccc3[nH]ncc3c2CN(Cc2ccccc2)C1=O.O=C1Nc2ccccc2CC1N1CCNCC1>>O=C1Nc2ccccc2CC1N1CCN(C(=O)C[C@@H]2Cc3ccc4[nH]ncc4c3CN(Cc3ccccc3)C2=O)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1cc(OC)ccc1C.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>CCOC(=O)c1cc(OC)ccc1CBr",
        "output": "545"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(O)CN.CCN(CC)CC.ClCCl.O=[N+]([O-])c1cnc2cc(OCc3ccccc3)ccc2c1Cl>>CC(C)(O)CNc1c([N+](=O)[O-])cnc2cc(OCc3ccccc3)ccc12",
        "output": "78"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)C(=O)Nc1ccc(-c2cc(=O)c3c(NCCCOS(C)(=O)=O)c(F)cc(F)c3o2)cc1F.CN(C)C=O.CN1CCNCC1.O>>CN1CCN(CCCNc2c(F)cc(F)c3oc(-c4ccc(NC(=O)C(C)(C)C)c(F)c4)cc(=O)c23)CC1",
        "output": "496"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cc1cc(OCc2coc(/C=C/c3ccc(Cl)cc3F)n2)ccc1CSCCn1ccnn1.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cc1cc(OCc2coc(/C=C/c3ccc(Cl)cc3F)n2)ccc1CS(=O)CCn1ccnn1",
        "output": "13"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.O=[N+]([O-])c1cc(F)ccc1NC1CCN(Cc2ccccc2)CC1.[Pt]>>Nc1cc(F)ccc1NC1CCN(Cc2ccccc2)CC1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.O=C(O)c1cc(C(F)(F)F)ccc1O>>OCc1cc(C(F)(F)F)ccc1O",
        "output": "72"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(C)=O.CCOC(=O)C(C)Br.O=C([O-])[O-].Oc1cc(-c2ccccc2)nc2ccccc12.[K+].[K+]>>CCOC(=O)C(C)Oc1cc(-c2ccccc2)nc2ccccc12",
        "output": "455"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCN(CC1CC1)c1cc(C(=O)O)ncn1.CCN(CC)CC.CCOC(=O)CCCS(=O)(=O)c1ccc(N)cc1.COC(=O)Cl.ClCCl.O>>CCCN(CC1CC1)c1cc(C(=O)Nc2ccc(S(=O)(=O)CCCC(=O)OCC)cc2)ncn1",
        "output": "548"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC1(c2ccc(C#Cc3ccc(CC(=O)OC)cc3)cc2C(C)(C)C)CC1.[Na+].[OH-]>>CCOC1(c2ccc(C#Cc3ccc(CC(=O)O)cc3)cc2C(C)(C)C)CC1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C=C(Cl)Cl)CCCl.COCCOCCOC.ClCCl.O=C([O-])[O-].Oc1ccc(Cl)cc1.[K+].[K+]>>CC(C)(C=C(Cl)Cl)CCOc1ccc(Cl)cc1",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COC(OC)OC.Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1.ClCCCl.OC1CC2(CCNCC2)C1.[Na+]>>Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC4(CC3)CC(O)C4)n(C)c2n1",
        "output": "944"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12.O=C(O)c1ccc(Br)cn1>>O=C(Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12)c1ccc(Br)cn1",
        "output": "548"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)[C@@H]1C[C@@]2(CN(c3cccc(Cl)c3)C(=O)O2)CN1C(=O)[C@@H](NC(=O)OC1CCCC1)C(C)(C)C.[Li+].[OH-]>>CC(C)(C)[C@H](NC(=O)OC1CCCC1)C(=O)N1C[C@@]2(C[C@H]1C(=O)O)CN(c1cccc(Cl)c1)C(=O)O2",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)C(=O)Cl.CCN(C(C)C)C(C)C.CN(C)C=O.O=C(NC1CNC1)c1cnc(-c2cccc(F)c2)nc1>>CC(C)(C)C(=O)N1CC(NC(=O)c2cnc(-c3cccc(F)c3)nc2)C1",
        "output": "125"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCC(N)CC1.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc([N+](=O)[O-])cc1F>>CN1CCC(NC(=O)c2ccc([N+](=O)[O-])cc2F)CC1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[B-](F)(F)F.NCc1nc(C(F)(F)F)no1.O=C(O)c1cnc(OCC(F)(F)F)c(I)c1.[Na+].[OH-]>>O=C(NCc1nc(C(F)(F)F)no1)c1cnc(OCC(F)(F)F)c(I)c1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "N#Cc1ccc(N)cc1C(F)(F)F.O.S=C(Cl)Cl>>N#Cc1ccc(N=C=S)cc1C(F)(F)F",
        "output": "114"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cccc([N+](=O)[O-])c1C.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>CCOC(=O)c1cccc([N+](=O)[O-])c1CBr",
        "output": "545"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)N.CC(C)Nc1cccnc1N1CCN(C(=O)c2ccc(C(=O)O)cn2)CC1>>CC(C)Nc1cccnc1N1CCN(C(=O)c2ccc(C(=O)NC(C)(C)C)cn2)CC1",
        "output": "674"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCCC(Oc1ccc(C(C)(C)CCC)cc1Cl)C(=O)O.Cc1ccccc1.O=S(Cl)Cl>>CCCCCCCCC(Oc1ccc(C(C)(C)CCC)cc1Cl)C(=O)Cl",
        "output": "53"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)c1cc(C(=O)O)cc(I)c1O.CO.O=S(=O)(O)O>>COC(=O)c1cc(I)c(O)c(C(C)(C)C)c1",
        "output": "195"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COc1ccccc1-c1nc(Cl)c2cc(F)ccc2n1.ClCCl.O=C([O-])O.[Na+]>>Oc1ccccc1-c1nc(Cl)c2cc(F)ccc2n1",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1nc(CCc2c(-c3ccc(F)cn3)noc2C)sc1C(=O)O.NCC1CC1>>Cc1nc(CCc2c(-c3ccc(F)cn3)noc2C)sc1C(=O)NCC1CC1",
        "output": "534"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.NCCC(O)C1CCC(N)CC1>>CC(C)(C)OC(=O)NCCC(O)C1CCC(N)CC1",
        "output": "631"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(Cc1c[nH]c2ccccc12)(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.CCOC(C)=O.NCCc1ccccc1.Oc1c(F)c(F)c(F)c(F)c1F>>CC(Cc1c[nH]c2ccccc12)(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)NCCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Nc1cccc(N)c1.CCN(C(C)C)C(C)C.Fc1cnc(Cl)nc1Cl>>CC(C)(C)OC(=O)Nc1cccc(Nc2nc(Cl)ncc2F)c1",
        "output": "352"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C(=O)OC(C)(C)C)[C@@H]1CNC[C@H]1c1ccc(Cl)c(Cl)c1.CS(=O)(=O)N1CCN(C(=O)Cl)CC1.ClCCl>>CN(C(=O)OC(C)(C)C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1",
        "output": "258"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.Cl.O=C([O-])[O-].[K+].[K+].c1ccc(CC2(N3CCOCC3)CCC3(CC2)OCCO3)cc1>>O=C1CCC(Cc2ccccc2)(N2CCOCC2)CC1",
        "output": "251"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)OB(c2ccc(CBr)cc2)OC1(C)C.ClCCl.O=C1COCCN1.[H-].[Na+]>>CC1(C)OB(c2ccc(CN3CCOCC3=O)cc2)OC1(C)C",
        "output": "774"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C[Si](C)(C)c1cccc([N+](=O)[O-])c1.[Pd].c1ccccc1>>C[Si](C)(C)c1cccc(N)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C(C)(C)Br.Oc1ccc2c(c1)c(-c1ccccc1)c1n2CCCCC1>>CCOC(=O)C(C)(C)Oc1ccc2c(c1)c(-c1ccccc1)c1n2CCCCC1",
        "output": "305"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(C)=O.N#Cc1ccc(Oc2ccc(C=O)cc2)cc1Cl.O.O=C([O-])[O-].OO.[K+].[K+]>>NC(=O)c1ccc(Oc2ccc(C=O)cc2)cc1Cl",
        "output": "180"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CNC1CCCCC1NC.COc1cc(Br)ccc1OCOCC[Si](C)(C)C.ClCCl.O=P([O-])([O-])[O-].O=c1cc(Cl)cc[nH]1.[Cu]I.[K+].[K+].[K+]>>COc1cc(-n2ccc(Cl)cc2=O)ccc1OCOCC[Si](C)(C)C",
        "output": "349"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C(O)c1cccc([N+](=O)[O-])c1O.O=S(Cl)Cl>>COC(=O)c1cccc([N+](=O)[O-])c1O",
        "output": "33"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.C[C@H]1CNCCN1c1ncc(C(O)(C(F)(F)F)C(F)(F)F)cn1.Cl.Cl.ClCCl.O=C([O-])O.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl.[Na+]>>C[C@H]1CN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CCN1c1ncc(C(O)(C(F)(F)F)C(F)(F)F)cn1",
        "output": "99"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#CCO.CCN(CC)CC.CN(C)C=O.Cl[Pd]Cl.Clc1cc(Cl)c(I)c(Cl)c1.I[Cu]I.O.[Cl-].[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>OCC#Cc1c(Cl)cc(Cl)cc1Cl",
        "output": "664"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCCO.Nc1ncnc2ccc(-c3cc(F)cc(C(=O)O)c3)nc12>>Nc1ncnc2ccc(-c3cc(F)cc(C(=O)NCCO)c3)nc12",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.O=C(O)C[C@H](NC(=O)OCc1ccccc1)C(=O)O>>O=C1C[C@H](NC(=O)OCc2ccccc2)C(=O)O1",
        "output": "436"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NCc1nc2c(c(=O)[nH]1)COCC2.O.O=C(O)CN1CCC(C(=O)c2ccc(Cl)cc2)CC1.On1nnc2ccccc21>>O=C(CN1CCC(C(=O)c2ccc(Cl)cc2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COC(=O)c1ccc(-c2ccc3cc(OC)ccc3c2)nc1.ClCCl.[Na+].[OH-]>>COC(=O)c1ccc(-c2ccc3cc(O)ccc3c2)nc1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCC(=O)Cl.CCN(C(C)C)C(C)C.Cc1nnc2ccc(-c3cccc(N)c3)nn12.ClCCl.O>>CCCC(=O)Nc1cccc(-c2ccc3nnc(C)n3n2)c1",
        "output": "9"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CI.CN(C)C=O.Cc1c(O)ccc(C#N)c1N.O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(C#N)c(N)c1C",
        "output": "62"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.Cl.Cn1c(Cl)nc(-c2ccncc2)cc1=O.O=C(Nc1ccccc1)C1CCCNC1>>Cn1c(N2CCCC(C(=O)Nc3ccccc3)C2)nc(-c2ccncc2)cc1=O",
        "output": "36"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COC(=O)CCN.Cl.O.O=[N+]([O-])c1ccc(Cl)cc1CBr.[Li+].[OH-]>>COC(=O)CCNCc1cc(Cl)ccc1[N+](=O)[O-]",
        "output": "446"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CS(=O)(=O)c1ccc2nc(-c3ccc(Br)cc3)[nH]c2c1.O.O=P([O-])([O-])[O-].OB(O)c1ccccc1.[K+].[K+].[K+]>>CS(=O)(=O)c1ccc2nc(-c3ccc(-c4ccccc4)cc3)[nH]c2c1",
        "output": "837"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CC(=O)O)Cc1c[nH]c2ccccc12.ClCCl.Nc1ccccc1>>CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CC(=O)Nc1ccccc1)Cc1c[nH]c2ccccc12",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1c(C=O)[nH]c2c1C(=O)N(CCN1CCOCC1)CC2.Nc1cc(F)cc2c1NC(=O)C2>>Cc1c(C=C2C(=O)Nc3c(N)cc(F)cc32)[nH]c2c1C(=O)N(CCN1CCOCC1)CC2",
        "output": "440"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)C1=C(c2ccc(CCCOc3cc(F)ccc3F)cc2)CCN(C(=O)OC(C)(C)C)C1.Cl.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(c2ccc(CCCOc3cc(F)ccc3F)cc2)=C(C(=O)O)C1",
        "output": "58"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N1C(=O)[C@@H](CC(=O)NCC#N)O[C@H](c2ccccc2Cl)c2cc(Cl)ccc21.[N-]=[N+]=[N-].[Na+]>>CC(C)N1C(=O)[C@@H](CC(=O)NCc2nnn[nH]2)O[C@H](c2ccccc2Cl)c2cc(Cl)ccc21",
        "output": "366"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)(C)[SiH2]OC(C)(C)c1c(Br)cccc1-n1ccc2cc(C3CC3)ccc2c1=O.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.[K+]>>CC(C)(C)[SiH2]OC(C)(C)c1c(B2OC(C)(C)C(C)(C)O2)cccc1-n1ccc2cc(C3CC3)ccc2c1=O",
        "output": "942"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNC1.CCOC(C)=O.O=Cc1cc(-c2cccs2)ccc1F>>O=Cc1cc(-c2cccs2)ccc1N1CCCC1",
        "output": "868"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1Cc1cnc(SCc2c(F)ccc(F)c2F)n1-c1ccc(F)cc1>>NCc1cnc(SCc2c(F)ccc(F)c2F)n1-c1ccc(F)cc1",
        "output": "242"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCC(OC(c2cccc(C#CC3CCN(C(=O)OC(C)(C)C)CC3)c2)c2nc3ccccc3[nH]2)CC1.C[Si](C)(C)Cl.ClCCCl.Oc1ccccc1>>CN1CCC(OC(c2cccc(C#CC3CCNCC3)c2)c2nc3ccccc3[nH]2)CC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(N(C(=O)c2c3ccccc3nc3sccc23)S(=O)(=O)CCCC(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(N(C(=O)c2c3ccccc3nc3sccc23)S(=O)(=O)CCCC(=O)O)cc1",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCCCC(=O)O.COC(=O)CCCCOc1cc2c(c(Cl)c1Cl)C(=O)C(C)(C1CCCC1)C2.Cl.O>>CC1(C2CCCC2)Cc2cc(OCCCCC(=O)O)c(Cl)c(Cl)c2C1=O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrBr.CN(C)C=O.O.O=S([O-])[O-].Oc1ncccc1F.[Na+].[Na+]>>Oc1ncc(Br)cc1F",
        "output": "292"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cl.Clc1ncc(Br)cn1.FC1CNC1>>FC1CN(c2ncc(Br)cn2)C1",
        "output": "36"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.C[C@H](O)CCCCn1c(=O)c2c(nc(CN=[N+]=[N-])n2Cc2ccccc2)n(C)c1=O.[H][H].[Pd]>>C[C@H](O)CCCCn1c(=O)c2c(nc(CN)n2Cc2ccccc2)n(C)c1=O",
        "output": "89"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](NCC2CCC2)C1.CC(C)Sc1ccccc1C(=O)Cl.CCN(CC)CC.ClCCl>>CC(C)Sc1ccccc1C(=O)N(CC1CCC1)[C@H]1CCN(C(=O)OC(C)(C)C)C1",
        "output": "201"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(Cc1cc(C(=O)OCc2ccccc2)ccc1-c1cncc(CC(=O)O)c1)C(=O)OCc1ccccc1.CO.[Li+].[OH-]>>CCN(Cc1cc(C(=O)O)ccc1-c1cncc(CC(=O)O)c1)C(=O)OCc1ccccc1",
        "output": "290"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.COc1ccc(S(=O)(=O)Nc2cc(O)cc(Br)c2)cc1.O.[K+]>>COc1ccc(S(=O)(=O)Nc2cc(O)cc(B3OC(C)(C)C(C)(C)O3)c2)cc1",
        "output": "942"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOCC.FC(F)(F)c1cc(Cl)c(Br)c(Cl)c1.O=C=O.[Li]CCCC>>O=C(O)c1c(Cl)cc(C(F)(F)F)cc1Cl",
        "output": "654"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.O=C(OCc1ccccc1)c1ccc(N2CCC3(CC2)CCN(C2CCC2)CC3)nc1.[OH-].[OH-].[Pd+2]>>O=C(O)c1ccc(N2CCC3(CC2)CCN(C2CCC2)CC3)nc1",
        "output": "291"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=CC(=O)Cl.CCN(CC)CC.CN(C)C=O.N#Cc1cnc2ccc(N)cc2c1Nc1ccc(F)c(Cl)c1>>C=CC(=O)Nc1ccc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1",
        "output": "10"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C=O.O.O=S1(=O)N(CCCCl)c2cccc3c2N1CCC3.Oc1ccc(N2CCNCC2)cc1>>O=S1(=O)N(CCCN2CCN(c3ccc(O)cc3)CC2)c2cccc3c2N1CCC3",
        "output": "138"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cc1ccc(S(=O)(=O)n2cc(-c3ccc(C(=O)O)cc3)c3cc(-c4ccccc4)cnc32)cc1.Cl.[Na+].[OH-]>>O=C(O)c1ccc(-c2c[nH]c3ncc(-c4ccccc4)cc23)cc1",
        "output": "949"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCO.CN(C)c1ccc(-c2[nH]c(=O)c(C(=O)OCc3ccccc3)c(O)c2C=O)cc1.[BH4-].[Na+]>>CN(C)c1ccc(-c2[nH]c(=O)c(C(=O)OCc3ccccc3)c(O)c2CO)cc1",
        "output": "476"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)Cc1nc(N)sc1C1(C)CC1.Cl.Cl.F[P-](F)(F)(F)(F)F.O=C(O)Cc1ccc(-c2cnc3cc(-c4ccccn4)ccn23)cc1F>>CN(C)Cc1nc(NC(=O)Cc2ccc(-c3cnc4cc(-c5ccccn5)ccn34)cc2F)sc1C1(C)CC1",
        "output": "681"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.COC(=O)Cc1ccc(C#Cc2ccc(C3(OCC(C)(C)C)CC3)c(C)c2)cc1.[Na+].[OH-]>>Cc1cc(C#Cc2ccc(CC(=O)O)cc2)ccc1C1(OCC(C)(C)C)CC1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(O)Cc1ccnc(NC(=O)OC(C)(C)C)c1.CN(C)C=O.O=[N+]([O-])c1ccc(F)c2ccccc12.[Cl-].[H-].[NH4+].[Na+]>>CC(Cc1ccnc(NC(=O)OC(C)(C)C)c1)Oc1ccc([N+](=O)[O-])c2ccccc12",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCc1ccc(-c2ccc(-c3cnc(-c4ccc(C[C@H](NC(=O)c5ccc(C(C)(C)C)s5)C(=O)N5CC(C(=O)OC(C)(C)C)C5)cc4)nc3)c(F)c2)cc1.ClCCl.O=C(O)C(F)(F)F>>CCCCc1ccc(-c2ccc(-c3cnc(-c4ccc(C[C@H](NC(=O)c5ccc(C(C)(C)C)s5)C(=O)N5CC(C(=O)O)C5)cc4)nc3)c(F)c2)cc1",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)N(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2ccnc(C#N)c2)cc1C(F)(F)F.ClCCl.O=C(O)C(F)(F)F>>CC(C)N(C)c1cc2c(cc1C(F)(F)F)NC(=O)CC(c1ccnc(C#N)c1)=N2",
        "output": "930"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cl.NO.O=C(c1ccccc1)c1ccc(Br)cc1.c1ccncc1>>ON=C(c1ccccc1)c1ccc(Br)cc1",
        "output": "190"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.O=[N+]([O-])c1ccc(NC2CCCCC2)c([N+](=O)[O-])c1.[Pd]>>Nc1ccc(NC2CCCCC2)c(N)c1",
        "output": "204"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1c2cccc(C(=O)OC(C)(C)C)c2Sc2c(CC(=O)O)ccc(CN)c21.ClCCl.O=C([O-])O.OCc1ccccc1.[Na+]>>CN1c2cccc(C(=O)OC(C)(C)C)c2Sc2c(CC(=O)OCc3ccccc3)ccc(CN)c21",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CS(=O)(=O)C[C@@H]1CCCN1C(=O)OCc1ccccc1>>CS(=O)(=O)C[C@@H]1CCCN1",
        "output": "428"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#Cc1ccc(CCC(=O)OC)cc1.Cc1ccc(I)cc1>>COC(=O)CCc1ccc(C#Cc2ccc(C)cc2)cc1",
        "output": "664"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.Nc1nccc2cc(OC3CCCNC3)ccc12.O=Cc1ccccc1.[Na+]>>Nc1nccc2cc(OC3CCCN(Cc4ccccc4)C3)ccc12",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1C(F)(F)F)C(=O)O.CCN(C(C)C)C(C)C.ClC(Cl)Cl.Cn1ncc(Br)c1-c1cc(C(=O)O)sc1Cl.F[P-](F)(F)(F)(F)F.N[C@@H](Cc1ccc(F)cc1)CN1C(=O)c2ccccc2C1=O>>Cn1ncc(Br)c1-c1cc(C(=O)N[C@@H](Cc2ccc(F)cc2)CN2C(=O)c3ccccc3C2=O)sc1Cl",
        "output": "736"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(=O)Cn1c(=O)c2c(nc(Oc3cccc(OC(F)(F)F)c3)n2Cc2ccc(Cl)cc2)n(C)c1=O.CO.ClCCl.[BH4-].[Na+]>>CCC(O)Cn1c(=O)c2c(nc(Oc3cccc(OC(F)(F)F)c3)n2Cc2ccc(Cl)cc2)n(C)c1=O",
        "output": "91"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCC2=NCCCN2CC1.CC#N.FCCNCC1CCNC1.O=C(O)c1cn(C2CC2)c2c(Cl)c(F)c(F)cc2c1=O>>O=C(O)c1cn(C2CC2)c2c(Cl)c(N3CCC(CNCCF)C3)c(F)cc2c1=O",
        "output": "676"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](CN)C1.O=C(O)c1ccc(Cl)s1>>CC(C)(C)OC(=O)N1CC[C@H](CNC(=O)c2ccc(Cl)s2)C1",
        "output": "736"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cccc(Cl)n1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>Clc1cccc(CBr)n1",
        "output": "590"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(=Cc1ccc(OC)c(C(=O)OC(C)(C)C)c1)OC(C)C.Cc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)/C(=C/c1ccc(OC)c(C(=O)O)c1)OC(C)C",
        "output": "752"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)NC(C)C.COc1cc(Nc2nc3c(-c4cccc(CN)c4)cc(C)cn3n2)ccc1-n1cnc(C)c1.CS(=O)(=O)Cl.Cl.Cl.ClCCl>>COc1cc(Nc2nc3c(-c4cccc(CNS(C)(=O)=O)c4)cc(C)cn3n2)ccc1-n1cnc(C)c1",
        "output": "742"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.C[C@@H]1CCN(CCc2ccc(F)cc2)C[C@H]1CN=[N+]=[N-].[Pd]>>C[C@@H]1CCN(CCc2ccc(F)cc2)C[C@H]1CN",
        "output": "89"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc2cc(F)c(=O)[nH]c2c1.O=P(Cl)(Cl)Cl>>COc1ccc2cc(F)c(Cl)nc2c1",
        "output": "100"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCNCC1.O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1cnc(Br)s1>>CN1CCN(c2ncc(C(=O)NCc3cn(-c4ccccc4)c4cc(Cl)ccc4c3=O)s2)CC1",
        "output": "657"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.COc1ccc(S(=O)(=O)Cl)cc1.Cl.Nc1nc(-c2cccc3ccccc23)cs1.c1ccncc1>>COc1ccc(S(=O)(=O)Nc2nc(-c3cccc4ccccc34)cs2)cc1",
        "output": "637"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=[N+]([O-])c1cnc(Nc2cccc(CCCN3CCCC3)c2)nc1.[Pd]>>Nc1cnc(Nc2cccc(CCCN3CCCC3)c2)nc1",
        "output": "660"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)COC(=O)Cl.CN(C)C=O.CN1CCOCC1.Nc1nc(C(=O)O)c2ccccc2n1.OC1CCNC1>>Nc1nc(C(=O)N2CCC(O)C2)c2ccccc2n1",
        "output": "605"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Cl.N[C@@H](CC1CCCCC1)C(=O)O.O>>CC(C)(C)OC(=O)N[C@@H](CC1CCCCC1)C(=O)O",
        "output": "626"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)O.CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccc4nc(C)n(C5CN(C(=O)OC(C)(C)C)C5)c4c3)sc2c1-c1ccc(Cl)cc1.Cl>>CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccc4nc(C)n(C5CNC5)c4c3)sc2c1-c1ccc(Cl)cc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#C[C@]1(O)CCN(C)C1=O.NC(=O)c1nc(-c2cc(Br)ccc2F)cnc1N>>CN1CC[C@@](O)(C#Cc2ccc(F)c(-c3cnc(N)c(C(N)=O)n3)c2)C1=O",
        "output": "659"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CNOC.Cl.Cl.O.On1nnc2ccccc21>>CON(C)C(=O)C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "54"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrBr.CON=C(C(C)=O)C(=O)OC.ClC(Cl)Cl>>CON=C(C(=O)CBr)C(=O)OC",
        "output": "173"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(=O)NCc1cncc(Br)c1.CCOC(C)=O.CN(C)C=O.CN1C(=O)CCc2cc(B3OC(C)(C)C(C)(C)O3)c(F)cc21.O=C([O-])O.O=C([O-])[O-].[Na+].[Na+].[Na+]>>CCC(=O)NCc1cncc(-c2cc3c(cc2F)N(C)C(=O)CC3)c1",
        "output": "938"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C#N)c1cccc(C(=O)O)c1.CO.O=S(=O)(O)O>>COC(=O)c1cccc(C(C)C#N)c1",
        "output": "33"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CCc1nc(N)cc(N)c1C#N.c1ccncc1>>CCc1nc(NC(C)=O)cc(N)c1C#N",
        "output": "332"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C[C@H]1CCCC[C@H]1O.Clc1cc(Cl)ncn1.[Cl-].[H-].[NH4+].[Na+]>>C[C@H]1CCCC[C@H]1Oc1cc(Cl)ncn1",
        "output": "653"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1ccc(-c2ccc(CC(O)CO)c(-c3ccc4c(c3)C(C)(C)CCC4(C)C)c2)cc1.Cl.[Na+].[OH-]>>CC1(C)CCC(C)(C)c2cc(-c3cc(-c4ccc(C(=O)O)cc4)ccc3CC(O)CO)ccc21",
        "output": "5"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)Cl.CC(c1ccc(-c2ccccc2)c(F)c1)c1nc(CCO)no1.CCN(CC)CC>>CC(=O)OCCc1noc(C(C)c2ccc(-c3ccccc3)c(F)c2)n1",
        "output": "126"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C1Cc2cc(Br)ccc2N1.O=Cc1ccc2c(c1)CCO2>>O=C1Nc2ccc(Br)cc2C1=Cc1ccc2c(c1)CCO2",
        "output": "439"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NC1(C(=O)O)CCOCC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)c1ccncc1.Cc1ccc(C2CNCC(NC(=O)c3ccccc3)C2)cc1C.F[P-](F)(F)(F)(F)F>>Cc1ccc(C2CC(NC(=O)c3ccccc3)CN(C(=O)C3(NC(=O)OC(C)(C)C)CCOCC3)C2)cc1C",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)c1ccc(CCC(O)CC2CCCCC2)cc1NC(=O)CC1c2ccccc2Oc2ccccc21.O=C(O)CSCC(=O)OCc1ccccc1>>CC(C)(C)c1ccc(CCC(CC2CCCCC2)OC(=O)CSCC(=O)OCc2ccccc2)cc1NC(=O)CC1c2ccccc2Oc2ccccc21",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CO.Cn1cc2c(n1)C(=O)NCCC=CCCCn1cc(cn1)-c1cccc(n1)C(=O)N2.[Pd]>>Cn1cc2c(n1)C(=O)NCCCCCCCn1cc(cn1)-c1cccc(n1)C(=O)N2",
        "output": "143"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1cnc(Br)s1.OCC1CCNCC1>>O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1cnc(N2CCC(CO)CC2)s1",
        "output": "657"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1cn(C2CC2)c2c(F)c(N3CC(C)(O)C3)c(F)cc2c1=O.[Na+].[OH-]>>CC1(O)CN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)C1",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC(F)(F)F)C(=O)COC(C)=O.CO.[Na+].[OH-]>>CCN(CC(F)(F)F)C(=O)CO",
        "output": "687"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCC(=O)Nc1nn(COCC[Si](C)(C)C)c2cc(-c3ccc(OCc4ccccc4)cc3)c(-c3ccoc3)cc12.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.[F-]>>CCCC(=O)Nc1n[nH]c2cc(-c3ccc(OCc4ccccc4)cc3)c(-c3ccoc3)cc12",
        "output": "813"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CCOCCl.C[Si](C)(C)C(C(N)=O)[Si](C)(C)C.ClCCl.O=C([O-])O.O=c1cc[nH]c(=S)[nH]1.[I-].[Na+]>>CCOCn1ccc(=O)[nH]c1=S",
        "output": "712"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cl.ClCCl.NC1(c2ccccn2)CC1.O.O=C(O)c1cccc(I)c1.On1nnc2ccccc21>>O=C(NC1(c2ccccn2)CC1)c1cccc(I)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(C)(C)OC(=O)N[C@H](CCCNC(=O)OCc1ccccc1)C(=O)O.CCN(C(C)C)C(C)C.CNOC.Cl.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CON(C)C(=O)[C@@H](CCCNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C",
        "output": "54"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)[C@@](C)(CCBr)S(C)(=O)=O.CCOC(C)=O.CS(C)=O.[N-]=[N+]=[N-].[Na+]>>CCOC(=O)[C@@](C)(CCN=[N+]=[N-])S(C)(=O)=O",
        "output": "622"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.FC(F)(F)c1cc(Cl)ncc1Cl.O.[C-]#N.[C-]#N.[Zn+2]>>N#Cc1cc(C(F)(F)F)c(Cl)cn1",
        "output": "726"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc2c(NCc3ccc(NC(=O)C4CCN(Cc5ccccc5)CC4)cc3)nc(Cl)nc2c1.Cl.Cl.c1cnc(N2CCNCC2)nc1>>Cc1ccc2c(NCc3ccc(NC(=O)C4CCN(Cc5ccccc5)CC4)cc3)nc(N3CCN(c4ncccn4)CC3)nc2c1",
        "output": "36"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CCC(F)(F)C(=O)O.ClCCl.N[C@@H](CO)c1ccccc1>>C=CCC(F)(F)C(=O)N[C@@H](CO)c1ccccc1",
        "output": "599"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-c2nc(C3CCCN(C(C)=O)C3)cnc2N)cc1F.Cl.[Li+].[OH-]>>CC(=O)N1CCCC(c2cnc(N)c(-c3ccc(C(=O)O)c(F)c3)n2)C1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)OC(=O)Nc2ccc(OCCCCSc3ccc(F)cc3)cc21.OO>>CC1(C)OC(=O)Nc2ccc(OCCCCS(=O)c3ccc(F)cc3)cc21",
        "output": "199"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)c1sc(-c2cnc(Nc3ccc(F)c(Cl)c3)nc2NCCCOC)nc1-c1ccccn1.O.O.[Li+].[OH-]>>COCCCNc1nc(Nc2ccc(F)c(Cl)c2)ncc1-c1nc(-c2ccccn2)c(C(=O)O)s1",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)CC1CN=C(c2cc3cc(Oc4ccc(COCCOC)nc4)cc(OC4CCOCC4)c3[nH]2)S1.[Na+].[OH-]>>COCCOCc1ccc(Oc2cc(OC3CCOCC3)c3[nH]c(C4=NCC(CC(=O)O)S4)cc3c2)cn1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1CCNCC1NC(=O)OC(C)(C)C.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.O=C(O)CNc1cc(Cl)cc(Cl)c1.On1nnc2ccccc21>>CC1CCN(C(=O)CNc2cc(Cl)cc(Cl)c2)CC1NC(=O)OC(C)(C)C",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CC[N+](CC)(CC)Cc1ccccc1.Nc1nc(O)cc(C2CCCN(C(=O)OCc3ccccc3)C2)n1.O=P(Cl)(Cl)Cl.[Cl-].[Na+].[OH-]>>Nc1nc(Cl)cc(C2CCCN(C(=O)OCc3ccccc3)C2)n1",
        "output": "168"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCNCc1ccccn1.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1ccc(NCC(=O)O)cc1.F[B-](F)(F)F.O>>CCN(Cc1ccccn1)C(=O)CNc1ccc(C)cc1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)CC(C)NC(=O)Nc1ccc(C(C)(C)C)cc1.[BH4-].[Li+]>>CC(CCO)NC(=O)Nc1ccc(C(C)(C)C)cc1",
        "output": "225"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1cccc(O)c1.CO.O=Cc1ccc2c(c1)OCO2.[Na+].[OH-]>>O=C(C=Cc1ccc2c(c1)OCO2)c1cccc(O)c1",
        "output": "295"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)Cn1c(C)cc2c(C(F)(F)F)c(C#N)ccc21.[BH4-].[Li+]>>Cc1cc2c(C(F)(F)F)c(C#N)ccc2n1CCO",
        "output": "343"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.COc1ccc2c(O)c(-c3ccccc3)c(C3CC3)cc2c1.O=Cc1ccc(F)cc1.[H-].[Na+]>>COc1ccc2c(Oc3ccc(C=O)cc3)c(-c3ccccc3)c(C3CC3)cc2c1",
        "output": "564"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.O.O=Cc1c(Cl)ccc(Br)c1F.[BH4-].[Na+]>>OCc1c(Cl)ccc(Br)c1F",
        "output": "356"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=C(c1ccc(O)cc1)c1ccc(OCCCl)cc1)c1ccc2occc2c1.CN.CO>>CCC(=C(c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccc2occc2c1",
        "output": "279"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CC2CC1CN2.CC(C)=O>>CC(C)N1CC2CC1CN2C(=O)OC(C)(C)C",
        "output": "187"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1ccc(-c2noc(-c3ccc(N(C)C)c(N)c3)n2)cc1F.CS(=O)(=O)Cl.c1ccncc1>>COC(=O)c1ccc(-c2noc(-c3ccc(N(C)C)c(NS(C)(=O)=O)c3)n2)cc1F",
        "output": "194"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C)OB(c2ccc(C(=O)O)cc2)OC1(C)C.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.ClCCl.Cn1ccc(CCN)cc1=O.F[P-](F)(F)(F)(F)F>>Cn1ccc(CCNC(=O)c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)cc1=O",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCN3CC(C)C)cc1.CCN(CC)CC.CN(C)C=O.Nc1ccc(SCc2cccnn2)cc1.O.O=S(Cl)Cl>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4cccnn4)cc2)CCN3CC(C)C)cc1",
        "output": "170"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(C)=O.Fc1cc(-c2nc3ccccc3o2)ccc1CBr.O.[C-]#N.[Na+]>>N#CCc1ccc(-c2nc3ccccc3o2)cc1F",
        "output": "39"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CCO.CCOC(=O)c1cc2c(O)cccc2[nH]1.ClCC1CO1.O.[Na+].[OH-]>>CCOC(=O)c1cc2c(OCC3CO3)cccc2[nH]1",
        "output": "15"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC[C@H](CCS(C)(=O)=O)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(F)ccc34)nc12.ClCCl.NCCN.O=C(O)C(F)(F)F>>COC[C@H](CCS(C)(=O)=O)NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(F)ccc34)nc12",
        "output": "981"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Cn1ccn(C2CCc3ccccc3C2)c1=S.O=C(O)C(F)(F)F>>O=C(O)Cn1ccn(C2CCc3ccccc3C2)c1=S",
        "output": "278"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC1CCN(C(=O)N2CC(C(=O)O)CC(c3ccc(OC(F)(F)F)cc3)C2)CC1.COCCC(N)=NO>>COCCc1noc(C2CC(c3ccc(OC(F)(F)F)cc3)CN(C(=O)N3CCC(NC(=O)OC(C)(C)C)CC3)C2)n1",
        "output": "728"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.C[Si](C)(C)CCOCCl.Clc1ccnc2[nH]ccc12.[H-].[Na+]>>C[Si](C)(C)CCOCn1ccc2c(Cl)ccnc21",
        "output": "712"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NCC(F)(F)F.O=C(O)c1ccc2[nH]ccc2c1>>O=C(NCC(F)(F)F)c1ccc2[nH]ccc2c1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)Cn1ccc2ccc(OCc3cc(-c4ccc(F)c(C(F)(F)F)c4)nn3C)cc21.[Li+].[OH-]>>Cn1nc(-c2ccc(F)c(C(F)(F)F)c2)cc1COc1ccc2ccn(CC(=O)O)c2c1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CNc1nc(-c2cccnc2)nc2ccc(-c3ccc(OC)nc3)cc12.COc1cccc(B(O)O)c1.Oc1nc(-c2cccnc2)nc2ccc(Br)cc12>>COc1cccc(-c2ccc3nc(-c4cccnc4)nc(O)c3c2)c1",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCC(F)CO.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.c1ccncc1>>CCCCCC(F)COS(=O)(=O)c1ccc(C)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCNCC1.COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2c1OCC2CC(=O)O>>COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2c1OCC2CC(=O)N1CCN(C)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc2c(-c3ccc(C(F)(F)F)cc3)cccc2c1>>O=S(=O)(Oc1ccc2c(-c3ccc(C(F)(F)F)cc3)cccc2c1)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.CS(=O)(=O)CCc1ccc(OCc2ccccc2)c(F)c1.[Pd]>>CS(=O)(=O)CCc1ccc(O)c(F)c1",
        "output": "23"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[O-].C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.Cc1ccccc1.O.O=Cc1cccc([N+](=O)[O-])c1.[Br-].[K+]>>C=Cc1cccc([N+](=O)[O-])c1",
        "output": "649"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCC(=O)CC1.Clc1ccc2cc[nH]c2c1Cl>>CN1CC=C(c2c[nH]c3c(Cl)c(Cl)ccc23)CC1",
        "output": "607"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN1CCC2(CCCNC2)C1=O.Cl.ClCCl.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1>>CN1CCC2(CCCN(S(=O)(=O)c3ccc(C(F)(F)F)cc3)C2)C1=O",
        "output": "99"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCN=C=NCCCN(C)C.Cl.NC(Cc1cccc(SC(F)(F)F)c1)C(O)c1ccc(F)cc1.O.O.O=C(O)c1cccc2c1C=CCCC2.On1nnc2ccccc21>>O=C(NC(Cc1cccc(SC(F)(F)F)c1)C(O)c1ccc(F)cc1)c1cccc2c1C=CCCC2",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(NC(=O)OC(C)(C)C)cc1NC(=O)c1csc2c(NC3CC3)ncnc12.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(N)cc1NC(=O)c1csc2c(NC3CC3)ncnc12",
        "output": "782"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)CNc2cc([N+](=O)[O-])ccc2C1.CCOC(C)=O.[Pd]>>CC1(C)CNc2cc(N)ccc2C1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.CCN(CC)CC.CCOCC.ClCCl.O=C(N[C@H]1CCNC[C@H]1F)OCc1ccccc1.O=[N+]([O-])c1cc(F)ccc1F>>O=C(N[C@H]1CCN(c2ccc(F)cc2[N+](=O)[O-])C[C@H]1F)OCc1ccccc1",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCSc1nnc(-n2nc(C(=O)OC)cc2-c2ccccn2)s1.CO.Cl.[Na+].[OH-]>>CCSc1nnc(-n2nc(C(=O)O)cc2-c2ccccn2)s1",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.OCc1c(F)cnc2[nH]ccc12.[Mn+4].[O-2].[O-2]>>O=Cc1c(F)cnc2[nH]ccc12",
        "output": "179"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClC(Cl)Cl.OCc1ccc(Br)c(F)c1.[Mn+4].[O-2].[O-2]>>O=Cc1ccc(Br)c(F)c1",
        "output": "179"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C[C@@H]1CCCN1CCCOc1ccc(N2CCN(C(=O)OC(C)(C)C)CC2=O)cc1.ClCCl.O=C(O)C(F)(F)F>>C[C@@H]1CCCN1CCCOc1ccc(N2CCNCC2=O)cc1",
        "output": "634"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.NCc1ccc(Oc2ccccc2)s1.Nc1ncccc1C(=O)O.O>>Nc1ncccc1C(=O)NCc1ccc(Oc2ccccc2)s1",
        "output": "674"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCc1nc(NC(C)C)c([N+](=O)[O-])cc1Br.Cl.O>>CCc1nc(NC(C)C)c(N)cc1Br",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(CC)CC.CSc1cc(C)nc(SC)c1N.O.O=C(Cl)CCl>>CSc1cc(C)nc(SC)c1NC(=O)CCl",
        "output": "422"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COC(=O)c1ccc(C2(NC(=O)c3cc(Cl)cnc3N3CCC(Oc4ccc(C(F)(F)F)cc4)C3)CC2)cc1.O.O.[Li+].[OH-]>>O=C(O)c1ccc(C2(NC(=O)c3cc(Cl)cnc3N3CCC(Oc4ccc(C(F)(F)F)cc4)C3)CC2)cc1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCc1cc(NC(=O)NC[C@@H]2CCCN(CC(=O)c3ccc(F)cc3)C2)cc(-c2nnnn2C)c1.CO.O.[BH4-].[Na+]>>CCc1cc(NC(=O)NC[C@@H]2CCCN(CC(O)c3ccc(F)cc3)C2)cc(-c2nnnn2C)c1",
        "output": "24"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)OC(=O)N1CCC([C@@H](C)O)CC1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)OC(=O)N1CCC([C@@H](C)OS(C)(=O)=O)CC1",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Fc1ccccc1N1CCNCC1.O=C(O)c1c[nH]c2cc(Cl)ccc12>>O=C(c1c[nH]c2cc(Cl)ccc12)N1CCN(c2ccccc2F)CC1",
        "output": "256"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.Cc1ccc(C(=O)NC(N)C(Cl)(Cl)Cl)cc1.O=C=Nc1ccccc1>>Cc1ccc(C(=O)NC(NC(=O)Nc2ccccc2)C(Cl)(Cl)Cl)cc1",
        "output": "35"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Clc1ncc2c(n1)O[C@H](c1ccccc1)CNC2.FCCBr>>FCCN1Cc2cnc(Cl)nc2O[C@H](c2ccccc2)C1",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCCC1CN.CNS(=O)(=O)c1cc2c(c(C(=O)Cl)c1)OCCO2.ClC(Cl)Cl.O>>CNS(=O)(=O)c1cc2c(c(C(=O)NCC3CCCN3C)c1)OCCO2",
        "output": "271"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C1(F)CCN(C2=NOC3(C2)CN(C(=O)OC(C)(C)C)C3)CC1.CCOc1cc(C=O)cc(OCC)c1-c1ccc(F)cc1>>CCOC(=O)C1(F)CCN(C2=NOC3(C2)CN(Cc2cc(OCC)c(-c4ccc(F)cc4)c(OCC)c2)C3)CC1",
        "output": "935"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)C1=C(c2ccccc2)CCN(C(=O)OC(C)(C)C)C1.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(c2ccccc2)=C(C(=O)O)C1",
        "output": "122"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)=O.CCCCCCON=C(C(=O)O)c1csc(NC=O)n1.CCOC(C)=O.CN(C)C=O.Cl.NC1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(Cl)CS[C@H]12.O.O=P(Cl)(Cl)Cl>>CCCCCCON=C(C(=O)NC1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(Cl)CS[C@H]12)c1csc(NC=O)n1",
        "output": "587"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)CN(c1ccc2c(ccn2-c2cc(Cl)nc(Cl)n2)c1)S(=O)(=O)c1cc(Cl)cc(Cl)c1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)CN(c1ccc2c(ccn2-c2cc(Cl)nc(Cl)n2)c1)S(=O)(=O)c1cc(Cl)cc(Cl)c1",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.Fc1cccc2[nH]ccc12.O.[BH3-]C#N.[Na+]>>Fc1cccc2c1CCN2",
        "output": "672"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCCC(=O)O.NC(CC(=O)OCc1ccccc1)c1ccccc1>>CC(C)(C)OC(=O)NCCC(=O)NC(CC(=O)OCc1ccccc1)c1ccccc1",
        "output": "599"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)OC(=O)/N=N/C(=O)OC(C)C.CC1(C)OB(c2ccc(O)c([N+](=O)[O-])c2)OC1(C)C.CN1CCC(O)CC1.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN1CCC(Oc2ccc(B3OC(C)(C)C(C)(C)O3)cc2[N+](=O)[O-])CC1",
        "output": "846"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)c1ccc(O)c(C(=O)O)c1.Nc1ccc([N+](=O)[O-])cc1Cl>>CC(C)(C)c1ccc(O)c(C(=O)Nc2ccc([N+](=O)[O-])cc2Cl)c1",
        "output": "50"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.NC1CC1.O=C(O)C(O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1ccccc1F>>O=C(NC1CC1)C(O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1ccccc1F",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2ccc(C)c(-c3cccc(C=O)c3)c2)c1.C[C@H]1CNC[C@@H](C)N1.ClCCl.[Na+]>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2ccc(C)c(-c3cccc(CN4C[C@H](C)N[C@H](C)C4)c3)c2)c1",
        "output": "567"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.O.O=C([O-])O.[Na+].c1ccc(CN2C3CCC2CNC3)cc1>>CC(C)(C)OC(=O)N1CC2CCC(C1)N2Cc1ccccc1",
        "output": "694"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)c1nc(N2CCN[C@H](C)C2)c(C#N)cc1Br.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COCCC(=O)O.ClCCl.F[P-](F)(F)(F)(F)F>>COCCC(=O)N1CCN(c2nc(C(C)C)c(Br)cc2C#N)C[C@H]1C",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NCC(=O)N[C@@H](CC(=O)OCc1ccccc1)C(=O)OC(C)(C)C.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1ccccc1>>CC(C)(C)OC(=O)NCC(=S)N[C@@H](CC(=O)OCc1ccccc1)C(=O)OC(C)(C)C",
        "output": "695"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Oc1ccccc1OC(C)C.CCOCC.ClCCl.ClI>>CC(=O)Oc1cc(I)ccc1OC(C)C",
        "output": "466"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCC.N#Cc1ccc(OCC(F)(F)F)c(F)c1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCc1ccc(OCC(F)(F)F)c(F)c1",
        "output": "175"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)CNC(=O)c1c(O)c2ccccc2n(OCc2nc3ccccc3s2)c1=O.ClCCl.O=C(O)C(F)(F)F>>O=C(O)CNC(=O)c1c(O)c2ccccc2n(OCc2nc3ccccc3s2)c1=O",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.Fc1cc(Cl)ccc1CBr.O=C([O-])[O-].O=c1ccc(Br)c[nH]1.[K+].[K+]>>O=c1ccc(Br)cn1Cc1ccc(Cl)cc1F",
        "output": "528"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.COc1cc(OC)cc(C(=O)[C@H]2[C@H](C)[C@@H](CNC(=O)c3ccccc3)C[C@H]3C(C)(C)CCC[C@]23C)c1.ClCCl>>C[C@H]1[C@H](C(=O)c2cc(O)cc(O)c2)[C@@]2(C)CCCC(C)(C)[C@@H]2C[C@@H]1CNC(=O)c1ccccc1",
        "output": "20"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCCCCCCCCCN1CCC(C(N)=O)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCCCCCCCCCCCCCN1CCC(CN)CC1",
        "output": "112"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCn1nc(C(C)(C)C)cc1C(=O)Nc1cccc(C(=O)Cl)c1.CN(C)c1ccncc1.ClCCl.OCCF>>CCn1nc(C(C)(C)C)cc1C(=O)Nc1cccc(C(=O)OCCF)c1",
        "output": "51"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-c2ccc(OCC3CCN(CC(C)(C)F)CC3)nc2)c(F)c1.O.O.[Li]O>>CC(C)(F)CN1CCC(COc2ccc(-c3ccc(C(=O)O)cc3F)cn2)CC1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(CCO)C(=O)Nc1nnc(C(F)(F)F)s1.O=S(Cl)Cl.c1ccccc1>>CN(CCCl)C(=O)Nc1nnc(C(F)(F)F)s1",
        "output": "96"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)C(=O)Cl.CCOCC.CN(C)c1ccncc1.ClCCl.Nc1c(F)cc(F)cc1Br.c1ccncc1>>CC(C)(C)C(=O)Nc1c(F)cc(F)cc1Br",
        "output": "9"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)O)CC1.c1ccc2c(c1)CCNC2>>CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)N2CCc3ccccc3C2)CC1",
        "output": "633"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC(C(=O)OC)c1c(C)nc(Cl)nc1-c1ccccc1.CCN(C(C)C)C(C)C.COCCOC.O.OB(O)c1ccccc1Cl.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCCC(C(=O)OC)c1c(C)nc(-c2ccccc2Cl)nc1-c1ccccc1",
        "output": "874"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)(P(=O)(OCC)OCC)P(=O)(OCC)c1ccccc1.CCOP(=O)(OCC)C(C)(O)P(=O)(O)c1ccccc1.Cl>>CC(O)(P(=O)(O)O)P(=O)(O)c1ccccc1",
        "output": "535"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCCCC12CCNCC2.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.Cl.F[P-](F)(F)(F)(F)F.N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)O)cc4)nn23)cc1.O>>CC(C)(C)OC(=O)N1CCCCC12CCN(C(=O)c1ccc(-c3ccc4ncc(-c5ccc(C#N)cc5)n4n3)cc1)CC2",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#Cc1cnc2ccc(-c3ccc(C(=O)N4CCOCC4)cc3)nn12.CS(=O)(=O)Nc1cccc(I)c1>>CS(=O)(=O)Nc1cccc(C#Cc2cnc3ccc(-c4ccc(C(=O)N5CCOCC5)cc4)nn23)c1",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)COc1cccc(C=O)c1.OC1CCNC1>>CC(C)COc1cccc(CN2CCC(O)C2)c1",
        "output": "567"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCO.CC[C@@H]1c2nncn2-c2cnc(Cl)nc2N1C1CCCC1.CN.O.O=C(O)C(F)(F)F.O=C([O-])[O-]>>CC[C@@H]1c2nncn2-c2cnc(NC)nc2N1C1CCCC1",
        "output": "544"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)c1cc(Cl)c(Nc2nc3ccc(-c4csc(C(C)(C)O)n4)cc3c3c(=O)[nH]ccc23)c(Cl)c1.C[Mg]Br>>CC(C)(O)c1cc(Cl)c(Nc2nc3ccc(-c4csc(C(C)(C)O)n4)cc3c3c(=O)[nH]ccc23)c(Cl)c1",
        "output": "586"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COc1c(C)c(CCCO)c(OC)c(OC)c1OC.CS(=O)(=O)Cl.ClCCl>>COc1c(C)c(CCCOS(C)(=O)=O)c(OC)c(OC)c1OC",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCC=O.CO.Cl.ClC(Cl)Cl.ClCCCl.O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(OC3CCNC3)cc12.[Na+]>>CCCN1CCC(Oc2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1",
        "output": "484"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Cl.Nc1ccc2[nH]ncc2c1>>COc1ccc2nc(Nc3ccc4[nH]ncc4c3)c3n[nH]cc3c2c1",
        "output": "998"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCc1ncc(CC(Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl.CCOCC.CO.Cl>>CCCCc1ncc(CC(Cc2ccccc2)C(=O)OC)n1Cc1ccccc1Cl",
        "output": "195"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccccc1.ClCCl.O=C(Cl)c1cc(Br)ccc1F.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(C(=O)c2cc(Br)ccc2F)cc1",
        "output": "61"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COc1cc(O)c(C(C)=O)c(OC)c1.COc1ccc(C=O)cc1.O.[K+].[OH-]>>COc1ccc(C=CC(=O)c2c(O)cc(OC)cc2OC)cc1",
        "output": "295"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1cccc(F)c1F.O=C(O)Cc1cc(Nc2ncnc3cc(OCc4ccccc4)ccc23)n[nH]1.O=P(Cl)(Cl)Cl.c1ccncc1>>O=C(Cc1cc(Nc2ncnc3cc(OCc4ccccc4)ccc23)n[nH]1)Nc1cccc(F)c1F",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(C(=O)O)cc2)CC1.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.N#Cc1cccc(OCCN)c1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(C(=O)NCCOc3cccc(C#N)c3)cc2)CC1",
        "output": "902"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NC1CCC(N)CC1.CC(C)(C)OC(=O)NCc1cc(F)c(Oc2cc(Oc3ccc(C#N)cc3)cc(C(=O)O)c2)c(F)c1>>CC(C)(C)OC(=O)NCc1cc(F)c(Oc2cc(Oc3ccc(C#N)cc3)cc(C(=O)NC3CCC(NC(=O)OC(C)(C)C)CC3)c2)c(F)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(O)CNC(=O)Cc1ccc(Cl)cc1.CO.Cc1ccccc1.II.[BH4-].[H][H].[Na+].[Na+].[OH-]>>CC(O)CNCCc1ccc(Cl)cc1",
        "output": "112"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.CCCCc1oc2ccccc2c1CCc1ccc(OC)cc1.ClCCl>>CCCCc1oc2ccccc2c1CCc1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccccc1.Cc1cc(C)cc(-c2c(OCCC3CCCCN3C(=O)OC(C)(C)C)c3cc([N+](=O)[O-])c(Cl)cc3n(C)c2=O)c1.O=C(O)C(F)(F)F>>Cc1cc(C)cc(-c2c(OCCC3CCCCN3)c3cc([N+](=O)[O-])c(Cl)cc3n(C)c2=O)c1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CC(=O)Cl.CCC1(C)CCC(C)C(C)(CC)N1.CCN(CC)CC.Cc1ccccc1>>C=CC(=O)N1C(C)(CC)CCC(C)C1(C)CC",
        "output": "135"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CSCCN1.CC(C)O.Cc1nc(C)c([N+](=O)[O-])c(Cl)c1Br>>Cc1nc(C)c([N+](=O)[O-])c(N2CCSCC2)c1Br",
        "output": "398"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cl.ClCCNCCCl.ClCCl.[Na+].[OH-]>>CC(C)(C)OC(=O)N(CCCl)CCCl",
        "output": "694"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOCC.Cc1ccc(S(=O)(=O)Cl)cc1.OC(CCCCCCCCCCCCOCc1ccccc1)CCCCCCCCCCCCOCc1ccccc1.c1ccncc1>>Cc1ccc(S(=O)(=O)OC(CCCCCCCCCCCCOCc2ccccc2)CCCCCCCCCCCCOCc2ccccc2)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cl.N[C@@H]1CCCC[C@H]1CN1CCCCC1.O=C=Nc1ccc(Cl)cc1>>O=C(Nc1ccc(Cl)cc1)N[C@@H]1CCCC[C@H]1CN1CCCCC1",
        "output": "35"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.COc1cccnc1N.ClC(Cl)Cl.O=C(Cl)c1cccc(I)c1>>COc1cccnc1NC(=O)c1cccc(I)c1",
        "output": "463"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.N#Cc1cccc(F)c1.O=C([O-])[O-].[Cu].[I-].[K+].[K+].[K+].c1c[nH]cn1>>N#Cc1cccc(-n2ccnc2)c1",
        "output": "701"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=Cc1sc(C(=O)OC)cc1-c1cnc2cccnn12.CO.[K+].[OH-]>>C=Cc1sc(C(=O)O)cc1-c1cnc2cccnn12",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)N(Cc1ccccc1)CC(O)COc1cccc([N+](=O)[O-])c1O.CCO.NN.O.[Ni]>>CC(C)(C)N(Cc1ccccc1)CC(O)COc1cccc(N)c1O",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Cl.CC(C)=O.CCN(CC)CC.Cl.Nc1ccccc1N1CCc2ccccc21>>CC(=O)Nc1ccccc1N1CCc2ccccc21",
        "output": "9"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.CCN(CC)CC.CN(C)C=O.O=C([O-])O.O=C1CCc2c(cccc2OCCCCl)N1.[I-].[Na+].[Na+].c1ccc(CN2CCNCC2)cc1>>O=C1CCc2c(cccc2OCCCN2CCN(Cc3ccccc3)CC2)N1",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.Cl.Cl.Cl.NCCN1CCN(c2ccccn2)CC1.O=C(O)CC1c2ccccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1>>O=C(CC1c2ccccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCN1CCN(c2ccccn2)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN.Fc1ccc(C2COCc3c(Cl)nc(Cl)nc32)cc1F>>CCNc1nc(Cl)nc2c1COCC2c1ccc(F)c(F)c1",
        "output": "110"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CCOCC.C[O-].Nc1cc(Cl)nc(Cl)c1[N+](=O)[O-].[Na+]>>COc1nc(Cl)cc(N)c1[N+](=O)[O-]",
        "output": "433"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc2cccccc1-2.Cl.ClCCl.O=C(Cl)c1cccc(Br)c1.[Al+3].[Cl-].[Cl-].[Cl-]>>Cc1cc(C(=O)c2cccc(Br)c2)c2cccccc1-2",
        "output": "61"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)c1nc2cc(S(=O)(=O)Cl)ccc2n1CC1CCC(F)(F)CC1.CCN(C(C)C)C(C)C.ClCCCl.O=C(NC1CC1)C1CNCCO1>>CC(C)(C)c1nc2cc(S(=O)(=O)N3CCOC(C(=O)NC4CC4)C3)ccc2n1CC1CCC(F)(F)CC1",
        "output": "99"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)C1(c2ccccn2)CCNCC1.O.[Li+].[OH-]>>O=C(O)C1(c2ccccn2)CCNCC1",
        "output": "615"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CNc1nc(-c2cccnc2)nc2ccc(O)cc12.ClCCCBr.O.O=C([O-])[O-].[K+].[K+]>>CNc1nc(-c2cccnc2)nc2ccc(OCCCCl)cc12",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN1C(=O)Cc2cc(CCC(=O)OC)ccc21.CO.Cl.[Na+].[OH-]>>CCN1C(=O)Cc2cc(CCC(=O)O)ccc21",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1c(N)ccc2c1CCC(N1CCOCC1)CC2.COc1cc(N2CCOCC2)ccc1Nc1nc(Cl)ncc1Cl>>COc1cc(N2CCOCC2)ccc1Nc1nc(Nc2ccc3c(c2OC)CCC(N2CCOCC2)CC3)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(S(=O)(=O)Cl)cc1.Nc1ccc(-c2nc3ncc(Cl)c(Cl)c3[nH]2)cc1>>COc1ccc(S(=O)(=O)Nc2ccc(-c3nc4ncc(Cl)c(Cl)c4[nH]3)cc2)cc1",
        "output": "68"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)(C)CNC(=O)c1ccc2cncc(Br)c2n1.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccc(F)cc1F.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(C)CNC(=O)c1ccc2cncc(-c3ccc(F)cc3F)c2n1",
        "output": "871"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCN(CCC)CCCCN(CC(=O)O)Cc1ccc(CN(Cc2ncc[nH]2)Cc2ncc[nH]2)cc1.CCO>>CCCN(CCC)CCCCN(CC(=O)OCC)Cc1ccc(CN(Cc2ncc[nH]2)Cc2ncc[nH]2)cc1",
        "output": "47"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCc1ccc(N=C=O)cc1.O=C(NCc1ccccc1Cl)N1CCC[C@H]1CO>>CCc1ccc(NC(=O)OC[C@@H]2CCCN2C(=O)NCc2ccccc2Cl)cc1",
        "output": "34"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.NCC1CC1.Nc1nc(Cl)cc(Cl)n1>>Nc1nc(Cl)cc(NCC2CC2)n1",
        "output": "166"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Clc1ccc2ncc(Br)n2n1.NCCO>>OCCNc1ccc2ncc(Br)n2n1",
        "output": "241"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.FC1(F)C[C@H]2C[C@@H]1C[C@@H]2OCc1ccccc1.[H][H].[Pd]>>O[C@H]1C[C@H]2C[C@@H]1CC2(F)F",
        "output": "178"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCCC(N)C1.O.O=C(Cl)OCC(Cl)(Cl)Cl.c1ccncc1>>CC(C)(C)OC(=O)N1CCCC(NC(=O)OCC(Cl)(Cl)Cl)C1",
        "output": "94"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1csc2nc(-c3ccncc3)nc(Cl)c12.NCCc1ccccc1>>Cc1csc2nc(-c3ccncc3)nc(NCCc3ccccc3)c12",
        "output": "723"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCCCOc1ccccc1.CO.C[O-].[Na+]>>COCCCOc1ccccc1",
        "output": "95"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O.O=Cc1ccc(Oc2ccc(Cl)nn2)cc1.[BH4-].[Na+]>>OCc1ccc(Oc2ccc(Cl)nn2)cc1",
        "output": "356"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccc(C(=O)O)cc1.CN(C)C=O.COc1cccc(CN)c1.ClCCCl.On1nnc2ccccc21>>COc1cccc(CNC(=O)c2ccc(C(C)=O)cc2)c1",
        "output": "753"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CCCCCCNC(=O)n1cc(CO[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O.O.O>>CCCCCCNC(=O)n1cc(CO)c(=O)n(C)c1=O",
        "output": "708"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)CCC(C)N1CCCC1.Cl.O.[Na+].[OH-]>>CC(CCC(=O)O)N1CCCC1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O=C1CC(c2cccc(Cl)c2)C2(C(=O)Nc3cc(Cl)ccc32)C(c2cccc(F)c2)N1.[BH4-].[Na+]>>O=C1Nc2cc(Cl)ccc2C12C(c1cccc(Cl)c1)CCNC2c1cccc(F)c1",
        "output": "533"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N1CCNCC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCCC(C=O)C1Cc1ccccc1.CC(Cl)Cl.[Na+]>>CC(=O)N1CCN(CC2CCCN(C(=O)OC(C)(C)C)C2Cc2ccccc2)CC1",
        "output": "484"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.COc1ncc(N2CCOc3ccc(O[C@H]4CCNC4)cc32)cc1C#N.ClCCCl.Cn1cnc(C(=O)O)c1.On1nnc2ccccc21>>COc1ncc(N2CCOc3ccc(O[C@H]4CCN(C(=O)c5cn(C)cn5)C4)cc32)cc1C#N",
        "output": "729"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCN(CCCC)C(=O)c1cc(C)n(-c2ccc(NC(=O)C(CC(=O)OC)c3ccccc3)cc2C(=O)N2Cc3ccccc3C[C@H]2CO)n1.O.O.[Li+].[OH-]>>CCCCN(CCCC)C(=O)c1cc(C)n(-c2ccc(NC(=O)C(CC(=O)O)c3ccccc3)cc2C(=O)N2Cc3ccccc3C[C@H]2CO)n1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CC(C)(C)[O-].COc1ccc(Cl)cc1.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>COc1ccc(N2CCCCC2)cc1",
        "output": "105"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCN=C=NCCCN(C)C.Cl.NCC1CCOCC1.NS(=O)(=O)c1ccc(C(=O)O)cc1.O.On1nnc2ccccc21>>NS(=O)(=O)c1ccc(C(=O)NCC2CCOCC2)cc1",
        "output": "835"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCN1CCOc2c(C#N)cc(C(=O)OC)cc21.CO.O.[K+].[OH-]>>CCCCN1CCOc2c(C#N)cc(C(=O)O)cc21",
        "output": "222"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)c1cc(C(=O)O)[nH]n1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cc1c(-c2ccn(C[C@H](C)N)n2)ccc(C#N)c1Cl.On1nnc2ccccc21>>CC(=O)c1cc(C(=O)N[C@@H](C)Cn2ccc(-c3ccc(C#N)c(Cl)c3C)n2)[nH]n1",
        "output": "816"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cccc2cc(CC(=O)O)oc12.O=C(Cl)C(=O)Cl>>COc1cccc2cc(CC(=O)Cl)oc12",
        "output": "56"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1ccc(O)cc1C.CCC(C)=O.Cl.ClCCN1CCOCC1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CC(=O)c1ccc(OCCN2CCOCC2)cc1C",
        "output": "74"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Nc1cccc2c(Cl)cccc12.CCO.[Na+].[OH-]>>Nc1cccc2c(Cl)cccc12",
        "output": "66"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.CNC.Cl.O.O=C(O)Cc1ccc(C=NNc2ccc(-c3cnco3)cc2)cc1>>CN(C)C(=O)Cc1ccc(C=NNc2ccc(-c3cnco3)cc2)cc1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C[Al+]CC(C)C.CC(C)C[AlH]CC(C)C.ClCCl.N#CC(N)Cc1ccccc1.[H-].[Na+].[OH-]>>NCC(N)Cc1ccccc1",
        "output": "246"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCc1cccc(N2CCSCC2)c1.ClCCl.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)OC(=O)NCc1cccc(N2CCS(=O)CC2)c1",
        "output": "13"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCO.CCOC(=O)c1cccc(C2=C(c3cc(C)ccc3OC(C)=O)CCC2)n1.CCOCC.O.[H-].[Na+]>>CCOC(=O)c1cccc(C2=C(c3cc(C)ccc3O)CCC2)n1",
        "output": "22"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCOc1ccc(-c2cc(CCl)on2)cc1.c1ccc(-c2nc3cn[nH]cc-3n2)cc1>>CCCCOc1ccc(-c2cc(Cn3cc4nc(-c5ccccc5)nc-4cn3)on2)cc1",
        "output": "997"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)CN(Cc1ccc(OCCc2nc(-c3ccc(C)cc3)oc2C)cc1)S(=O)(=O)N(C)C(=O)c1ccc(OC)cc1.O.[Li+].[OH-]>>COc1ccc(C(=O)N(C)S(=O)(=O)N(CC(=O)O)Cc2ccc(OCCc3nc(-c4ccc(C)cc4)oc3C)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.C1CCOC1.CCCCn1c(=O)c(NC(=O)Nc2cc(CBr)ccc2C(C)(C)C)c(-c2cccc(OC)c2)c2cccnc21.O>>CCCCn1c(=O)c(NC(=O)Nc2cc(CN3CCCC3)ccc2C(C)(C)C)c(-c2cccc(OC)c2)c2cccnc21",
        "output": "248"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.C1CCOC1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1CCN(Cc2cc(Cl)cc(Br)c2)CC1.CC(C)(C)[O-].CC(C)Oc1cccc(OC(C)C)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.O.[Na+].[Pd+2]>>CC(C)(C)OC(=O)N1CCN(Cc2cc(Cl)cc(N3CCCCC3)c2)CC1",
        "output": "953"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.O=Cc1cccc2c1B(O)OC2.OCC1CCNCC1.[Na+]>>OCC1CCN(Cc2cccc3c2B(O)OC3)CC1",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(=O)CC1.ClCCl.NCc1noc(-c2cc3cnccc3o2)n1>>CC(C)(C)OC(=O)N1CCC(NCc2noc(-c3cc4cnccc4o3)n2)CC1",
        "output": "236"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCC1CN(C(C)(C)C)CC2(CCN(C(=O)OC(C)(C)C)CC2)O1.Cl.ClCCl>>CCC1CN(C(C)(C)C)CC2(CCNCC2)O1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.N#Cc1cccc(OCCNC(=O)CC2CCNCC2)c1.O=C(O)c1ccccc1.On1nnc2ccccc21>>N#Cc1cccc(OCCNC(=O)CC2CCN(C(=O)c3ccccc3)CC2)c1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-c2ccc[n+]([O-])n2)s1.O.O.[Li]O>>O=C(O)c1ccc(-c2ccc[n+]([O-])n2)s1",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.N#Cc1cccc(OCCN)c1.O=C(O)C=Cc1ccc(Cl)cc1.On1nnc2ccccc21>>N#Cc1cccc(OCCNC(=O)/C=C/c2ccc(Cl)cc2)c1",
        "output": "549"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COCc1cc(C(=O)OC)ccc1-c1ccccc1C(F)(F)F.O.O.[Li+].[OH-]>>COCc1cc(C(=O)O)ccc1-c1ccccc1C(F)(F)F",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.C[C@H]1NCCC[C@H]1N1CCN(C)C1=O.N#Cc1ncc(Cl)nc1Cl>>C[C@@H]1[C@H](N2CCN(C)C2=O)CCCN1c1cnc(C#N)c(Cl)n1",
        "output": "505"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COC(=O)c1ccc(-c2nc(CSc3nc4c(c(-c5ccccc5)c3C#N)CCC4)cs2)cc1.Cl.[Na+].[OH-]>>N#Cc1c(SCc2csc(-c3ccc(C(=O)O)cc3)n2)nc2c(c1-c1ccccc1)CCC2",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C1COCCO1.CC(C)(C)OC(=O)NC1CCC(Sc2ccc(C(F)(F)F)cc2)CC1.CO.Cl>>NC1CCC(Sc2ccc(C(F)(F)F)cc2)CC1",
        "output": "538"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)C(C)=Cc1ccc(C=O)cc1.[BH4-].[BH4-].[Na+]>>CCOC(=O)C(C)=Cc1ccc(CO)cc1",
        "output": "356"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#Cc1c(N)ccc(C(=O)OC)c1Cl.CCOCCc1cc(C(=O)OC)c(Cl)c(C#C[Si](C)(C)C)c1N>>C#Cc1c(N)c(CCOCC)cc(C(=O)OC)c1Cl",
        "output": "337"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OCCCCCCOc1ccc(C(=O)Nc2cccc3c2OC(c2nnn[nH]2)CO3)cc1.CO.[Na+].[OH-]>>O=C(Nc1cccc2c1OC(c1nnn[nH]1)CO2)c1ccc(OCCCCCCO)cc1",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.C1COCCOCCOCCOCCOCCO1.CC(C)(C)[O-].CNC.COc1cc(C(=O)c2cccc(I)c2)c(Oc2c(Br)cc(CC(=O)O)cc2Br)cc1C(C)C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COc1cc(C(=O)c2cccc(N(C)C)c2)c(Oc2c(Br)cc(CC(=O)O)cc2Br)cc1C(C)C",
        "output": "931"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.O=c1nc(-c2cccc(CSCc3ccccc3)n2)sc2ccccc12>>O=c1nc(-c2cccc(CS(=O)Cc3ccccc3)n2)sc2ccccc12",
        "output": "13"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1=COCCC1.CCCc1nc(CO)c(Br)o1.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.O=C([O-])O.[Na+].c1cc[nH+]cc1>>CCCc1nc(COC2CCCCO2)c(Br)o1",
        "output": "141"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1ccc([N+](=O)[O-])c(N)n1.[Pd]>>Cc1ccc(N)c(N)n1",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#C[Si](C)(C)C.CC1(C)CC(=O)Sc2cc(Br)ccc21.CCN(CC)CC.Cl[Pd]Cl.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC1(C)CC(=O)Sc2cc(C#C[Si](C)(C)C)ccc21",
        "output": "671"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCOC(=O)C1CCc2nc(NC(C)=O)sc2C1.O.[Na+].[OH-]>>CC(=O)Nc1nc2c(s1)CC(C(=O)O)CC2",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCNC3)cc1.N#CCC(=O)Cl>>CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(C(=O)CC#N)C3)cc1",
        "output": "125"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(c1ccc(C(=O)O)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1.F[P-](F)(F)(F)(F)F.NC1CC1>>CN(c1ccc(C(=O)NC2CC2)cn1)[C@@H]1CCN(c2ncnc3[nH]ccc23)C1",
        "output": "674"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Nc1ccc(F)c(C(F)F)c1.O=C([O-])Cc1nc(N2CCOCC2)cc(=O)[nH]1.[Na+].c1ccncc1>>O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)Nc1ccc(F)c(C(F)F)c1",
        "output": "891"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.ClCCl.Nc1ccncc1.O=C(Cl)Oc1ccccc1>>O=C(Nc1ccncc1)Oc1ccccc1",
        "output": "102"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1n[nH]c2cc(Cl)c(-c3ccc(N4CCOCC4)cc3)cc12.[Na+].[OH-]>>O=C(O)c1n[nH]c2cc(Cl)c(-c3ccc(N4CCOCC4)cc3)cc12",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1ccccc1Oc1c(Cl)nc(-c2ccncc2)nc1NS(=O)(=O)c1ccc(C)cn1.[Na]>>COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OC",
        "output": "653"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)c1cc(NC(=O)[C@@H]2CCN2)no1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.Cl.O.O=C(O)C1CCC(F)(F)CC1.On1nnc2ccccc21>>CC(C)(C)c1cc(NC(=O)[C@@H]2CCN2C(=O)C2CCC(F)(F)CC2)no1",
        "output": "297"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)Cc1ccc(Nc2cc(-c3cccc(Cl)c3)nc(C3CC3)c2)cc1>>OCCc1ccc(Nc2cc(-c3cccc(Cl)c3)nc(C3CC3)c2)cc1",
        "output": "225"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)c1ccccc1COc1ccc(CCC(=O)N(C)CCc2ccc(OC)c(OC)c2)cc1.O.[Li+].[OH-]>>COc1ccc(CCN(C)C(=O)CCc2ccc(OCc3ccccc3C(=O)O)cc2)cc1OC",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1[C@H](C(=O)O)C[C@@]2(CO)C[C@@H]12.CC1(C)CCCC(N)C1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F>>CC1(C)CCCC(NC(=O)[C@@H]2C[C@@]3(CO)C[C@H]3N2C(=O)OC(C)(C)C)C1",
        "output": "216"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)O[AlH-](OC(C)(C)C)OC(C)(C)C.CC(C)n1c(C=O)c(-c2ccc(F)cc2)c(-c2ccccc2)c1C(=O)NCCc1cccnc1.[Li+]>>CC(C)n1c(CO)c(-c2ccc(F)cc2)c(-c2ccccc2)c1C(=O)NCCc1cccnc1",
        "output": "745"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.Nc1ccc(Br)cc1C(=O)c1ccccc1F.O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C([O-])[O-].[Na+].[Na+]>>O=C(c1ccccc1F)c1cc(Br)ccc1NC(=O)C(F)(F)F",
        "output": "106"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.N#Cc1c(CBr)cccc1[N+](=O)[O-].O.O=C([O-])[O-].Oc1ccc(F)cc1F.[K+].[K+].c1ccncc1>>N#Cc1c(COc2ccc(F)cc2F)cccc1[N+](=O)[O-]",
        "output": "127"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCOC(=O)c1cn(CC)c2cc(N3CCNCC3)ccc2c1=O.[K+].[OH-]>>CCn1cc(C(=O)O)c(=O)c2ccc(N3CCNCC3)cc21",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cl[Sn]Cl.Nc1nc2ccc([N+](=O)[O-])cc2s1>>Nc1ccc2nc(N)sc2c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.NCc1nc(-c2ccncc2)c[nH]1.O=C(O)c1cccs1>>O=C(NCc1nc(-c2ccncc2)c[nH]1)c1cccs1",
        "output": "736"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.C[C@H](O)[C@H](N)C(=O)O.O>>C[C@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)O",
        "output": "626"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)O.CC(Cl)Cl.CCN(C(C)C)C(C)C.CCOCC.CCOP(=O)(Cc1ccc(N)c(Br)c1)OCC.FC(F)(F)c1cnc(Cl)nc1Cl.[Cl-].[Cl-].[Zn+2]>>CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Cl)n2)c(Br)c1)OCC",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.ClC(Cl)Cl.O=C(O)c1ccc(Br)cc1.O=S(Cl)Cl>>O=C(Cl)c1ccc(Br)cc1",
        "output": "3"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CCCCCC.CCCCCCOc1ccc(OCCCCCC)cc1.O=[N+]([O-])O>>CCCCCCOc1ccc(OCCCCCC)c([N+](=O)[O-])c1",
        "output": "21"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCOc1cc(CN2CC3(CC(N4CCC(C(=O)OCC)CC4)=NO3)C2)cc(C2CC2)c1-c1ccc(F)cc1.CCO.[Na+].[OH-]>>CCCOc1cc(CN2CC3(CC(N4CCC(C(=O)O)CC4)=NO3)C2)cc(C2CC2)c1-c1ccc(F)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(Sc1nnn[nH]1)C1=C(C(=O)OC(C)(C)C)N2C(=O)C(N)[C@H]2SC1.O=C(O)CS(=O)C(F)(F)F.c1ccccc1>>CC(Sc1nnn[nH]1)C1=C(C(=O)OC(C)(C)C)N2C(=O)C(NC(=O)CS(=O)C(F)(F)F)[C@H]2SC1",
        "output": "133"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.Nc1nccc2ccccc12.O.O=C(Cl)Oc1ccccc1.c1ccncc1>>O=C(Nc1nccc2ccccc12)Oc1ccccc1",
        "output": "502"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CI.CN(C)C=O.Cc1ncc(OC[C@@]2(c3ccc(O)c(F)c3)C[C@H]2C(=O)Nc2ccc(F)cn2)c(C)n1.O.O=C([O-])[O-].[Cs+].[Cs+]>>COc1ccc([C@]2(COc3cnc(C)nc3C)C[C@H]2C(=O)Nc2ccc(F)cn2)cc1F",
        "output": "62"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.O=C([O-])[O-].OCCOCCCl.[I-].[K+].[K+].[K+].c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>OCCOCCN1CCN(C(c2ccccc2)c2ccccc2)CC1",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1ccc(N(c2ccccc2)c2ccccc2)cc1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].Cc1ccccc1.Nc1ccccc1.[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>c1ccc(Nc2ccc(N(c3ccccc3)c3ccccc3)cc2)cc1",
        "output": "405"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.C=C(C)C.Cc1c(C(=O)O)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1.O=S(=O)(O)O>>Cc1c(C(=O)OC(C)(C)C)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1",
        "output": "511"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CNCCN1.CC(C)Cn1c(=O)n(C)c(=O)c2c(-c3cc(C(=O)O)cn3C)n(Cc3c[nH]c4ccc(Cl)cc34)nc21.CCOP(=O)(C#N)OCC>>CC(C)Cn1c(=O)n(C)c(=O)c2c(-c3cc(C(=O)N4CCNCC4)cn3C)n(Cc3c[nH]c4ccc(Cl)cc34)nc21",
        "output": "256"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1cnc2c(c1)OCCN2.COc1c(C2CCC2)ccc(B(O)O)c1F>>COc1c(C2CCC2)ccc(-c2cnc3c(c2)OCCN3)c1F",
        "output": "833"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.CCOP(=O)(C#N)OCC.CSc1ccc(N)c(N(C)C(=O)OC(C)(C)C)c1.O=C(O)COc1ccc(CC2SC(=O)NC2=O)cc1>>CSc1ccc(NC(=O)COc2ccc(CC3SC(=O)NC3=O)cc2)c(N(C)C(=O)OC(C)(C)C)c1",
        "output": "365"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCC=O.NC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C1.[Na+]>>CCCNC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C1",
        "output": "426"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CC2CNCC1O2.CCN(CC)CC.CN(C)C=O.COc1ccc(NC(=O)c2ccc(-c3ccccc3)cc2)cc1NC(=O)CCl.Cl.[I-].[K+]>>COc1ccc(NC(=O)c2ccc(-c3ccccc3)cc2)cc1NC(=O)CN1CC2CCC(C1)O2",
        "output": "340"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "B.C1CCOC1.NC(=O)CCCCCc1cccnc1>>NCCCCCCc1cccnc1",
        "output": "112"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(O)C1CCNCC1.CCN(C(C)C)C(C)C.CN(C)C=O.O=C(O)c1ccc2nc(Cl)nc(N3CCOCC3)c2n1>>CC(C)(O)C1CCN(C(=O)c2ccc3nc(Cl)nc(N4CCOCC4)c3n2)CC1",
        "output": "605"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COc1cc(C(=O)CBr)ccc1-c1ccccn1.Nc1ccccn1>>COc1cc(-c2cn3ccccc3n2)ccc1-c1ccccn1",
        "output": "508"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrP(Br)Br.ClCCl.O=C([O-])O.O=c1cc(OCc2ccccc2F)ccn1CCc1ccc(CO)cc1.[Na+]>>O=c1cc(OCc2ccccc2F)ccn1CCc1ccc(CBr)cc1",
        "output": "300"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)NC1CCN(Cc2ccccc2)C1.CCO.O.[C].[Pd]>>CC(=O)NC1CCNC1",
        "output": "84"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[Si](C)(C)Cl.O=C1CCC(CCC(O)Cc2cccc(F)c2)N1>>CC(C)(C)[Si](C)(C)OC(CCC1CCC(=O)N1)Cc1cccc(F)c1",
        "output": "193"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)c1nc2c(c(-c3ccc(F)cc3)c1C(OC(C)(C)C)C(=O)O)CNCC2(C)C.CCN(CC)CC.CO.ClCCl.O=C(Cl)[C@@H]1C[C@H]1c1ccccc1>>CC(C)c1nc2c(c(-c3ccc(F)cc3)c1C(OC(C)(C)C)C(=O)O)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)CC2(C)C",
        "output": "125"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCN1.Cc1ccccc1.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)cc1F.[K+].[K+]>>O=[N+]([O-])c1ccc(Cl)cc1N1CCOCC1",
        "output": "26"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.O.O=C1CCC(=O)N1Br.c1cc2c(cn1)-c1sccc1CCO2>>Brc1cc2c(s1)-c1cnccc1OCC2",
        "output": "807"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)Cn1nc(Br)c(Br)c1Br.N>>NC(=O)Cn1nc(Br)c(Br)c1Br",
        "output": "163"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)C1CC(CCCC(C)(F)F)CN1C(=O)OC(C)(C)C.O.O.[Li+].[OH-]>>CC(F)(F)CCCC1CC(C(=O)O)N(C(=O)OC(C)(C)C)C1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3ncc(Br)n4ncnc34)cc2)C(=O)C1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>O=C1CNCCN1c1ccc(Nc2ncc(Br)n3ncnc23)cc1",
        "output": "634"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "B.C1CCOC1.CNS(=O)(=O)CCCCC(=O)O.CO>>CNS(=O)(=O)CCCCCO",
        "output": "231"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1ccc(Cl)nc1.CCOC(C)=O.NC1CC1>>CCOC(=O)c1ccc(NC2CC2)nc1",
        "output": "70"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.CC#N.Cc1ccccc1-n1nc(-c2c(-c3ccc(F)cc3)nn3c2N(CCCOS(C)(=O)=O)CC3)ccc1=O.O.O=C([O-])[O-].[K+].[K+]>>Cc1ccccc1-n1nc(-c2c(-c3ccc(F)cc3)nn3c2N(CCCN2CCOCC2)CC3)ccc1=O",
        "output": "496"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.Cl.ClC(Cl)Cl.O.O=C(Nc1cnc(-c2ccccc2)cn1)Oc1ccccc1.O=C1OC2(CCNCC2)c2cc(O)ccc21>>O=C1OC2(CCN(C(=O)Nc3cnc(-c4ccccc4)cn3)CC2)c2cc(O)ccc21",
        "output": "525"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#C[Si](C)(C)C.O=C([O-])[O-].[K+].[K+]>>C#Cc1cc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)ccc1C",
        "output": "337"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCC/C(=C\\c1c(C)c(OC)c(OC)c(OC)c1OC)C(=O)OCC.CCOCC>>CCCC/C(=C\\c1c(C)c(OC)c(OC)c(OC)c1OC)C(=O)O",
        "output": "122"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CBr.CN(C)C=O.Oc1cccc(Br)c1>>CCOC(=O)COc1cccc(Br)c1",
        "output": "123"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.COC(=O)C1CC(F)(F)CN1C(=O)OC(C)(C)C.O.[Li+].[OH-]>>CC(C)(C)OC(=O)N1CC(F)(F)CC1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C1NCCCn2c1cc1cc(F)cc(Br)c12.OB(O)c1ccc(F)c(F)c1>>O=C1NCCCn2c1cc1cc(F)cc(-c3ccc(F)c(F)c3)c12",
        "output": "833"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCC1CCC1.COc1ccc(S(=O)(=O)N2CCC3=Cc4c(cnn4-c4ccc(F)cc4)C[C@]3(C(=O)O)C2)cn1>>COc1ccc(S(=O)(=O)N2CCC3=Cc4c(cnn4-c4ccc(F)cc4)C[C@]3(C(=O)OCC3CCC3)C2)cn1",
        "output": "416"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1cc(Br)c2ccccc2n1.CNC.O>>CN(C)c1cc(Br)c2ccccc2n1",
        "output": "647"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CN(Cc1cccc(C(F)(F)F)c1)S(=O)(=O)c1ccc(Br)cc1.CC1(C)OB(c2ccc(-c3c(Cc4ccccc4)oc4ccccc34)cc2)OC1(C)C.CCOC(C)=O.CS(C)=O.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>CC(C)(C)OC(=O)CN(Cc1cccc(C(F)(F)F)c1)S(=O)(=O)c1ccc(-c2ccc(-c3c(Cc4ccccc4)oc4ccccc34)cc2)cc1",
        "output": "933"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCN(CC)CC.CCOCn1cc(Cl)c(O)cc1=O.O=C(Cl)c1ccccc1>>CCOCn1cc(Cl)c(OC(=O)c2ccccc2)cc1=O",
        "output": "482"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1c(Nc2cc(F)cc(F)c2[N+](=O)[O-])sc2ccccc12.CCOC(C)=O.[C].[H][H].[Pd]>>CCOC(=O)c1c(Nc2cc(F)cc(F)c2N)sc2ccccc12",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)OC(=O)N1CCC(O)CC1.CN(C)C=O.COc1c(Cl)ncnc1Cl.O.[H-].[Na+]>>COc1c(Cl)ncnc1OC1CCN(C(=O)OC(C)C)CC1",
        "output": "653"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O.CCO.Cl.Nn1ccnc1N1CCOCC1>>CC(C)(C)c1cc(C=Nn2ccnc2N2CCOCC2)cc(C(C)(C)C)c1O",
        "output": "167"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(=O)(=O)Cl.Nc1ccc(I)cc1F.O.c1ccncc1>>CS(=O)(=O)Nc1ccc(I)cc1F",
        "output": "194"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cc1cc(C#N)cc([N+](=O)[O-])c1NC(=O)C(F)(F)F.N>>Cc1cc(C#N)cc([N+](=O)[O-])c1N",
        "output": "491"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1onc(-c2ccccc2)c1COc1ccc(N)nn1.O=C(Cl)C1CC1>>Cc1onc(-c2ccccc2)c1COc1ccc(NC(=O)C2CC2)nn1",
        "output": "527"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1noc(-c2ccc(S(C)(=O)=O)cc2F)n1.[Li+].[OH-]>>CS(=O)(=O)c1ccc(-c2nc(C(=O)O)no2)c(F)c1",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCI)ccc21.CN(C)C=O.O=c1[nH]c2ccccc2cc1Br.[Br-].[H-].[Li+].[Na+]>>CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCn3c(=O)c(Br)cc4ccccc43)ccc21",
        "output": "302"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CC=O)c2cc1C.Cl.Cl.Nc1ccc(N)c(C(=O)O)c1>>Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCNc3ccc(N)c(C(=O)O)c3)c2cc1C",
        "output": "336"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C1Nc2ccccc2SC1CCCCO.O=S(Cl)Cl>>O=C1Nc2ccccc2SC1CCCCCl",
        "output": "96"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1.ClCCl>>COc1ccccc1N1CCN(CCCCN)CC1",
        "output": "242"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=C1Nc2ccc(OCCCCSc3ccc(Cl)cc3)cc2CO1.OO>>O=C1Nc2ccc(OCCCCS(=O)c3ccc(Cl)cc3)cc2CO1",
        "output": "199"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)c1nccc(Oc2ccc(NC(=O)c3cc(F)cc(N4CCOCC4)c3)c3ccccc23)n1.NC1CC1>>O=C(Nc1ccc(Oc2ccnc(NC3CC3)n2)c2ccccc12)c1cc(F)cc(N2CCOCC2)c1",
        "output": "629"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)C=O.Nc1ccc(Oc2cccnc2Cl)nc1.O=C(O)c1c[nH]c2ccccc12>>O=C(Nc1ccc(Oc2cccnc2Cl)nc1)c1c[nH]c2ccccc12",
        "output": "863"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.Cc1nc(-c2cccc(NC(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Cl)n2)s1.Cl.Nc1ccc(OCCN2CCCC2)c(Cl)c1>>Cc1nc(-c2cccc(NC(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Nc3ccc(OCCN4CCCC4)c(Cl)c3)n2)s1",
        "output": "907"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cn(Cc2ccc(OCc3csc(-c4ccccc4)n3)cc2)nc1-c1cccs1.Cl.[Na+].[OH-]>>O=C(O)c1cn(Cc2ccc(OCc3csc(-c4ccccc4)n3)cc2)nc1-c1cccs1",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)O)cc3)c(Cl)cc21.CN(C)C=O.Cl.ClCCl.NCc1ccc(Cl)c(Cl)c1.On1nnc2cccnc21>>CCOC(=O)C1CCOc2cc(Oc3ccc(C(=O)NCc4ccc(Cl)c(Cl)c4)cc3)c(Cl)cc21",
        "output": "753"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClC(Cl)Cl.O=C([O-])O.O=S(Cl)Cl.OCCCc1nc2ccccc2n1-c1ccccc1.[Na+]>>ClCCCc1nc2ccccc2n1-c1ccccc1",
        "output": "96"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNC1.Cc1ccc(-c2oncc2C(=O)O)cc1>>Cc1ccc(-c2oncc2C(=O)N2CCCC2)cc1",
        "output": "975"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.COc1cc([N+](=O)[O-])ccc1N.Cc1ccccc1.O=C(Cl)c1ccccc1>>COc1cc([N+](=O)[O-])ccc1NC(=O)c1ccccc1",
        "output": "11"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=C(O)c1ccc([N+](=O)[O-])cc1Br.O=S(Cl)Cl>>COC(=O)c1ccc([N+](=O)[O-])cc1Br",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClCCl.Nc1ccc2nc(-c3ccccc3)cc(OCC(=O)N3CCOCC3)c2c1>>CC(=O)Nc1ccc2nc(-c3ccccc3)cc(OCC(=O)N3CCOCC3)c2c1",
        "output": "9"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCCN.CCN(C(C)C)C(C)C.CCO.Clc1ncc(Br)c(Cl)n1>>CC(C)(C)OC(=O)NCCNc1nc(Cl)ncc1Br",
        "output": "110"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].O=C1CCc2cc(Cl)c(Cl)cc21.[BH3-]C#N.[NH4+].[Na+]>>NC1CCc2cc(Cl)c(Cl)cc21",
        "output": "552"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.C[Si](C)(C)C=[N+]=[N-].ClCCl.O=C(O)C1CC(Cl)C1>>COC(=O)C1CC(Cl)C1",
        "output": "195"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cnc2c(-c3cccc(Cl)c3)cnn2c1.O=C(O)c1ccn2ncc(-c3cccc(Cl)c3)c2n1>>O=C(O)c1cnc2c(-c3cccc(Cl)c3)cnn2c1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCCCN(C(=O)c1ccccc1Cl)c1nnc(-c2cc(Cl)nc(OC)c2)s1.C[Si](C)(C)Cl.O.[I-].[Na+]>>CCCCN(C(=O)c1ccccc1Cl)c1nnc(-c2cc(Cl)[nH]c(=O)c2)s1",
        "output": "758"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)C(CCOc1ccc(CCCCNC(=O)OCc2ccccc2)cc1)NC(=O)OC(C)(C)C.N>>CC(C)(C)OC(=O)NC(CCOc1ccc(CCCCNC(=O)OCc2ccccc2)cc1)C(N)=O",
        "output": "432"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCC[Si]1(c2ccccc2)CCC(C=Cc2ccc(OCC)cc2)CC1.CCOC(C)=O.[C].[H][H].[Pd]>>CCCCC[Si]1(c2ccccc2)CCC(CCc2ccc(OCC)cc2)CC1",
        "output": "362"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Fc1cccc(F)c1CBr.O.O=C([O-])[O-].O=[N+]([O-])c1ncc(Cl)cc1O.[Cs+].[Cs+]>>O=[N+]([O-])c1ncc(Cl)cc1OCc1c(F)cccc1F",
        "output": "623"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)Cc1csc2cc(OCC(C)c3nc(-c4ccc(C(F)(F)F)cc4)sc3C)ccc12.Cl.[Na+].[OH-]>>Cc1sc(-c2ccc(C(F)(F)F)cc2)nc1C(C)COc1ccc2c(CC(=O)O)csc2c1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)OC(=O)/N=N/C(=O)OC(C)C.ClCCl.N#Cc1ccc(N2CCCCN2CCO)c2ccccc12.Oc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1ccc(N2CCCCN2CCOc2ccccc2)c2ccccc12",
        "output": "478"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(NC2CCCCC2)c([N+](=O)[O-])c1C.[OH-].[OH-].[Pd+2]>>COC(=O)c1ccc(NC2CCCCC2)c(N)c1C",
        "output": "481"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1nc(-n2ccc(O)cc2=O)sc1C(=O)O.NCc1ccncc1>>Cc1nc(-n2ccc(O)cc2=O)sc1C(=O)NCc1ccncc1",
        "output": "534"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.Cc1cc(O)ccc1Br.Cc1cccc(-n2nnn(C)c2=O)c1CBr.O.O=C([O-])[O-].[K+].[K+]>>Cc1cc(OCc2c(C)cccc2-n2nnn(C)c2=O)ccc1Br",
        "output": "127"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC.N#CC1(c2ccccc2)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCC1(c2ccccc2)CC1",
        "output": "246"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.Cc1cc2cc(-c3cnn(C4CCCCO4)c3)ccc2n1CC1CCNCC1.ClCCl.O=C(Cl)CCc1ccccc1.O=C([O-])O.[Na+]>>Cc1cc2cc(-c3cnn(C4CCCCO4)c3)ccc2n1CC1CCN(C(=O)CCc2ccccc2)CC1",
        "output": "125"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(C)=O.CCCC#CC(O)CCCl.[I-].[Na+]>>CCCC#CC(O)CCI",
        "output": "97"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Cl.O=C(O)c1cc(Cl)ccc1Br>>OCc1cc(Cl)ccc1Br",
        "output": "72"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCCC(CCCCCC)COc1ccccc1C(=O)O.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl>>CCCCCCCCC(CCCCCC)COc1ccccc1C(=O)Cl",
        "output": "448"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NC(=O)Cn1cnc2cc(-c3cn(S(=O)(=O)c4ccccc4)c4cc(F)ccc34)ccc21.O=S(=O)(c1ccccc1)n1cc(I)c2ccc(F)cc21>>NC(=O)Cn1cnc2cc(-c3c[nH]c4cc(F)ccc34)ccc21",
        "output": "771"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.Cl.Cn1cc(Br)cc(Nc2ccc(C3=CCN(C(=O)OC(C)(C)C)CC3)cn2)c1=O>>Cn1cc(Br)cc(Nc2ccc(C3=CCNCC3)cn2)c1=O",
        "output": "800"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN1CCC(N)CC1.Clc1ccc2c(Cl)c3c(nc2c1)CCCC3>>CCN1CCC(Nc2c3c(nc4cc(Cl)ccc24)CCCC3)CC1",
        "output": "78"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Br[Co]Br.CC(=O)O.CC(C)(C)OC(=O)N1CCOC(c2ccc(Cl)c(Cl)c2)C(N=[N+]=[N-])C1.CCO.[BH4-].[Na+].c1ccc(-c2ccccn2)nc1>>CC(C)(C)OC(=O)N1CCOC(c2ccc(Cl)c(Cl)c2)C(N)C1",
        "output": "89"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(CC)C(=O)Nc1nc(C)c(OCc2ccccc2)c(C)c1C.CO.[Pd]>>CCC(CC)C(=O)Nc1nc(C)c(O)c(C)c1C",
        "output": "264"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.c1ccc2c(N3CCNCC3)nsc2c1>>CC(C)(C)OC(=O)N1CCN(c2nsc3ccccc23)CC1",
        "output": "694"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCC1CCCSC1.CC#N.O=C([O-])[O-].O=[N+]([O-])c1cc(O)c(Cl)cc1F.[I-].[K+].[K+].[K+]>>O=[N+]([O-])c1cc(OCC2CCCSC2)c(Cl)cc1F",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCC1CCC1.Nc1cccnc1C(=O)O>>Nc1cccnc1C(=O)NCC1CCC1",
        "output": "137"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COCCOc1ccc(-c2c(C#N)c(N)nc(SC(C)c3cccc(C(=O)OC)c3)c2C#N)cc1.Cl.[Li+].[OH-]>>COCCOc1ccc(-c2c(C#N)c(N)nc(SC(C)c3cccc(C(=O)O)c3)c2C#N)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C1COCCOCCOCCOCCO1.CS(=O)(=O)c1cccc(S(=O)(=O)Cl)c1.O=C([O-])O.O=Cc1c[nH]c(-c2cccnc2F)c1Cl.[H-].[Na+].[Na+]>>CS(=O)(=O)c1cccc(S(=O)(=O)n2cc(C=O)c(Cl)c2-c2cccnc2F)c1",
        "output": "648"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.COc1cc(C)nc(N)n1.O=C=NS(=O)(=O)c1csc2ccccc12>>COc1cc(C)nc(NC(=O)NS(=O)(=O)c2csc3ccccc23)n1",
        "output": "566"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)CCCN.Cc1c(S(=O)(=O)Cl)sc2nc[nH]c(=O)c12.Cl.ClCCl>>Cc1c(S(=O)(=O)NCCCN(C)C)sc2nc[nH]c(=O)c12",
        "output": "600"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O.OCC1CCOCC1>>Cc1ccc(S(=O)(=O)OCC2CCOCC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CCc1nc(C)n(-c2ccccc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCc1nc(C)n(-c2ccccc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1ccc2c(c1)OCC2(C)c1ccc2c(c1)C(C)(C)CCC2(C)C.[Li+].[Na+].[OH-].[OH-]>>CC1(C)CCC(C)(C)c2cc(C3(C)COc4cc(C(=O)O)ccc43)ccc21",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)CNc1nnc(-c2ccc(F)c(C#N)c2)o1.Cl>>N#Cc1cc(-c2nnc(NCC(=O)O)o2)ccc1F",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.Cl.O=C([O-])[O-].O=C1c2ccccc2C(=O)N1CCBr.Oc1ccc(S)cc1.[K+].[K+]>>O=C1c2ccccc2C(=O)N1CCSc1ccc(O)cc1",
        "output": "124"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCCBr.CCCCCCCCC1CCc2c(cc(F)c(F)c2-c2ccc(O)cc2)C1(F)F.CCOCC>>CCCCCCCCOc1ccc(-c2c(F)c(F)cc3c2CCC(CCCCCCCC)C3(F)F)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccccc1.NCCc1ccccc1.O=Cc1ccccc1OCCCN1CCCCC1>>C(=NCCc1ccccc1)c1ccccc1OCCCN1CCCCC1",
        "output": "52"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(-n2c(=O)n(-c3ccc(Cl)cc3)c3c(N)ncnc32)c1.ClCCl.O=C(O)C(F)(F)F>>Nc1cccc(-n2c(=O)n(-c3ccc(Cl)cc3)c3c(N)ncnc32)c1",
        "output": "782"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(Cl)Cl.CCN(c1cc(Cl)cc(C(=O)OC)c1C)[C@@H]1CC[C@@H](NC)CC1.COc1ccc(C=O)cc1.[BH3-]C#N.[Na+].[Ti+4]>>CCN(c1cc(Cl)cc(C(=O)OC)c1C)[C@@H]1CC[C@@H](N(C)Cc2ccc(OC)cc2)CC1",
        "output": "567"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.Cl.N#Cc1cccc(C2=C(C(=O)O)CCC2)c1.Nc1ccc(N2CCCCC2=O)cc1.O.O.Oc1cccc2[nH]nnc12>>N#Cc1cccc(C2=C(C(=O)Nc3ccc(N4CCCCC4=O)cc3)CCC2)c1",
        "output": "170"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN(C)C=O.COC(=O)CCN.Cl.Clc1cc(Cl)nc(Cc2ccccc2)n1.O>>COC(=O)CCNc1cc(Cl)nc(Cc2ccccc2)n1",
        "output": "166"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.COC(=O)c1csc(-n2c(=O)n(CC(=O)OC(C)(C)C)c3ccccc32)n1.Cl>>COC(=O)c1csc(-n2c(=O)n(CC(=O)O)c3ccccc32)n1",
        "output": "278"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1ccc(C2(NC(=O)[C@H]3CCCCN3Cc3ccc(F)c(C)c3)CC2)cc1.O.[Li]O>>Cc1cc(CN2CCCC[C@@H]2C(=O)NC2(c3ccc(C(=O)O)cc3)CC2)ccc1F",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1.O=C1CCC(n2ccnc2)CC1>>O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(n3ccnc3)CC2)C1",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)c1cc(F)c([N+](=O)[O-])cc1F.C[O-].[Na+]>>COc1cc(N(C)C)c(F)cc1[N+](=O)[O-]",
        "output": "485"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O=C(Cl)CCCl.O=C1CCc2cccc3c2N1CC3>>O=C(CCCl)c1cc2c3c(c1)CCN3C(=O)CC2",
        "output": "31"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1cc2c(Oc3cc(C)c(C)nc3-c3ccc(C)cn3)ccnc2cc1O.ClCCBr.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(Oc3cc(C)c(C)nc3-c3ccc(C)cn3)ccnc2cc1OCCCl",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "N#Cc1cc(-c2ccnc3c2cc(-c2ccc(C(=O)C(F)(F)F)cc2)n3S(=O)(=O)c2ccccc2)ccc1OC1CCOCC1.O=C([O-])[O-].OCC(F)(F)F.[Cs+].[Cs+]>>N#Cc1cc(-c2ccnc3[nH]c(-c4ccc(C(=O)C(F)(F)F)cc4)cc23)ccc1OC1CCOCC1",
        "output": "831"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C1COCCN1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.O=C([O-])[O-].O=[N+]([O-])c1ccc2c(C(O)(CCO)C(F)(F)F)cn(Cc3ccccc3)c2c1.[K+].[K+].[Na+]>>O=[N+]([O-])c1ccc2c(C(O)(CCN3CCOCC3)C(F)(F)F)cn(Cc3ccccc3)c2c1",
        "output": "371"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CN1CCCC1=O.COc1cc(Cl)c(-n2c(=O)[nH]c3c(OC)nc(Cl)nc32)cc1OCc1c(F)cccc1OC.NCCO.[Cl-].[NH4+]>>COc1cc(Cl)c(-n2c(=O)[nH]c3c(OC)nc(NCCO)nc32)cc1OCc1c(F)cccc1OC",
        "output": "578"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)CN(C(=O)OCC)C(CC)Cc1cccs1.O.[Na+].[OH-]>>CCOC(=O)N(CC(=O)O)C(CC)Cc1cccs1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(=O)CC1CCc2c1[nH]c1ccc(OCc3ccc(S(C)(=O)=O)cc3)cc21.[Li+].[OH-]>>CS(=O)(=O)c1ccc(COc2ccc3[nH]c4c(c3c2)CCC4CC(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CC1(C)CC1.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Nc1ccc([N+](=O)[O-])cc1Br.[Cu]I>>Nc1ccc([N+](=O)[O-])cc1",
        "output": "350"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc2c(C)nnc(Cl)c2c1.NC1CCN(Cc2ccccc2)CC1>>COc1ccc2c(C)nnc(NC3CCN(Cc4ccccc4)CC3)c2c1",
        "output": "241"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCCCCCOC1CCCCO1.CN(C)C=O.COC(=O)c1csc(-c2cccc(O)c2)n1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1csc(-c2cccc(OCCCCCOC3CCCCO3)c2)n1",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(Cc1ccc2c(c1)COC2=C1C(=O)Nc2ccccc21)OC.O.O=S(=O)(O)O>>O=CCc1ccc2c(c1)COC2=C1C(=O)Nc2ccccc21",
        "output": "234"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CNC1.CC1(OC(=O)N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)O)c(F)c3)CC2)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F>>CC1(OC(=O)N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)N4CCC4)c(F)c3)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1=COCCC1.CC(=O)c1ccc(O)cc1.Cc1ccc(S(=O)(=O)O)cc1.ClCCl>>CC(=O)c1ccc(OC2CCCCO2)cc1",
        "output": "319"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CO.COc1cc(OC)c(F)c(N2Cc3cnc(-c4cn(C)nc4C)cc3N(C3CCN(C(=O)OC(C)(C)C)CC3)C2=O)c1F.Cl>>COc1cc(OC)c(F)c(N2Cc3cnc(-c4cn(C)nc4C)cc3N(C3CCNCC3)C2=O)c1F",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1C[C@@H](O)[C@H](N=[N+]=[N-])C1.CCOCC.CI.CN(C)C=O.O.[H-].[Na+]>>CO[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1N=[N+]=[N-]",
        "output": "140"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CN1CC[C@]2(c3cccc(O)c3)CC(=O)CC[C@@H]2C1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-].[H-].[Na+]>>C=C1CC[C@@H]2CN(C)CC[C@]2(c2cccc(O)c2)C1",
        "output": "601"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4O)no2)cc1C#N.ClCCl.c1ccncc1>>CC(=O)O[C@@H]1CCc2c(-c3noc(-c4ccc(OC(C)C)c(C#N)c4)n3)cccc21",
        "output": "126"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)Cn1c(=O)n(C)c(=O)c2c(-c3cc(C(=O)O)cn3C)n(Cc3c[nH]c4ccc(Cl)cc34)nc21.CCOP(=O)(C#N)OCC.NCCN1CCOCC1>>CC(C)Cn1c(=O)n(C)c(=O)c2c(-c3cc(C(=O)NCCN4CCOCC4)cn3C)n(Cc3c[nH]c4ccc(Cl)cc34)nc21",
        "output": "674"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1cc(C2CC2)c2c(C)c(Cl)ccn2c1=O.OB(O)c1cccc(F)c1>>COC(=O)c1cc(C2CC2)c2c(C)c(-c3cccc(F)c3)ccn2c1=O",
        "output": "947"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[Si](C)(C)OCCCNC(=O)c1cc([N+](=O)[O-])c(Sc2c(Cl)cncc2Cl)s1.CCOCC.Cl.O>>O=C(NCCCO)c1cc([N+](=O)[O-])c(Sc2c(Cl)cncc2Cl)s1",
        "output": "708"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[O-].CCOCC.CCSc1ccccc1C=O.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.O=C([O-])O.[I-].[K+].[Na+]>>C=Cc1ccccc1SCC",
        "output": "649"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Cl.O.O=C(Cc1cccc(OCc2ccccc2)c1)Nc1ccc(Cl)c(Cl)c1.[K+].[OH-]>>Clc1ccc(NCCc2cccc(OCc3ccccc3)c2)cc1Cl",
        "output": "112"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=S(Cl)Cl.OCc1cc2c(cn1)[nH]c1ccccc12>>ClCc1cc2c(cn1)[nH]c1ccccc12",
        "output": "594"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N(Cc1ccc2c(c1)OCCO2)C1CCN(C(=O)C(F)(F)F)CC1.CO.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N(Cc1ccc2c(c1)OCCO2)C1CCNCC1",
        "output": "703"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CS(=O)CCOc1cccc(C=O)c1.[BH4-].[Na+]>>CS(=O)CCOc1cccc(CO)c1",
        "output": "356"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CCc1ccc2c(c1O)CCN(C(=O)C(F)(F)F)CC2.CCOC(C)=O.[Pd]>>CCCc1ccc2c(c1O)CCN(C(=O)C(F)(F)F)CC2",
        "output": "116"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(C)(C)c1ccc(O)c(C(F)(F)F)c1.O.O=[N+]([O-])O>>CC(C)(C)c1cc([N+](=O)[O-])c(O)c(C(F)(F)F)c1",
        "output": "21"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1ncc2nc(-c3ccc(C#N)cc3)sc2c1O.CO.C[O-].NCC(=O)O.[Na+]>>N#Cc1ccc(-c2nc3cnc(C(=O)NCC(=O)O)c(O)c3s2)cc1",
        "output": "977"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C1CCc2[nH]c3ccc(N)cc3c2C1.COC(=O)Cl.ClCCl>>COC(=O)Nc1ccc2[nH]c3c(c2c1)CC(N(C)C)CC3",
        "output": "102"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cc(Cl)ccc1C(=O)O.Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CN)c1>>COc1cc(Cl)ccc1C(=O)NC[C@@H]1[C@H]2C[C@H]2CN1C(=O)c1nc(C)sc1-c1cccc(C)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)C1(c2ccc(Nc3cc(-c4ccccc4)nc(-c4ccc(F)cc4)n3)cc2)CCC1.Cl.O.OCCO.[Na+].[OH-]>>O=C(O)C1(c2ccc(Nc3cc(-c4ccccc4)nc(-c4ccc(F)cc4)n3)cc2)CCC1",
        "output": "203"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CSc1ccc([N+](=O)[O-])cc1O.O.[Cl-].[NH4+].[Zn]>>CSc1ccc(N)cc1O",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.C1CN(C2CC2)CCN1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1cc(C[C@@H](NC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc(Cl)c1N.F[B-](F)(F)F.O=C([O-])O.On1nnc2ccccc21.[Na+]>>Cc1cc(C[C@@H](NC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCN(C3CC3)CC2)cc(Cl)c1N",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc2c(nnn2CC2CC2)c1C(F)(F)F>>O=S(=O)(Oc1ccc2c(nnn2CC2CC2)c1C(F)(F)F)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.CC(C)[C@@H](C)/C=C/[C@@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C.O.c1ccncc1>>CC(=O)O[C@H]1CC[C@@]2(C)C(=CC=C3[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)/C=C/[C@H](C)C(C)C)CC[C@@H]32)C1",
        "output": "254"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc2c(cc1N)CCN(CC(=O)N(C)C)CC2.Clc1ncc(Cl)c(Nc2ccc(N3CCOCC3)cc2-n2cccn2)n1>>COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccc(N4CCOCC4)cc3-n3cccn3)n1)CCN(CC(=O)N(C)C)CC2",
        "output": "808"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC1CCC(=O)C1.CO.[BH4-].[Na+]>>CC(C)(C)OC(=O)NC1CCC(O)C1",
        "output": "91"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCC(Oc2ccc(C(=O)O)cc2C(F)(F)F)CC1.F[P-](F)(F)(F)(F)F.N[C@H]1[C@@H]2c3cc(Oc4ccnc5c4CCC(=O)N5)ccc3O[C@@H]21>>CN1CCC(Oc2ccc(C(=O)N[C@H]3[C@@H]4c5cc(Oc6ccnc7c6CCC(=O)N7)ccc5O[C@@H]43)cc2C(F)(F)F)CC1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COCC1CCC(=O)CC1.O=C(CNc1nn(CCO)c2ccc(C(F)(F)F)cc12)NC1CNC1.O=C(O)C(F)(F)F>>COCC1CCC(N2CC(NC(=O)CNc3nn(CCO)c4ccc(C(F)(F)F)cc34)C2)CC1",
        "output": "187"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(OC)c(F)c(N2Cc3cnc(S(C)=O)nc3N(C3CCCC3)C2=O)c1.NC[C@H](O)[C@@H](O)CO>>COc1cc(OC)c(F)c(N2Cc3cnc(NC[C@H](O)[C@@H](O)CO)nc3N(C3CCCC3)C2=O)c1",
        "output": "666"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCOC(=O)c1cnn(-c2cc(SC)nc(C)n2)c1N.Cl.O.[Li+].[OH-]>>CSc1cc(-n2ncc(C(=O)O)c2N)nc(C)n1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCCN.CCN(C(C)C)C(C)C.CCOC(C)=O.CCc1cc(-c2noc(-c3cc(C)nc(NC(C)C)n3)n2)cc(C)c1CCC(=O)O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[B-](F)(F)F>>CCc1cc(-c2noc(-c3cc(C)nc(NC(C)C)n3)n2)cc(C)c1CCC(=O)NCCNC(=O)OC(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[O-].O=C(O)CC(O)(CC(=O)O)C(=O)O.O=S(=O)(NCc1ccccc1)Nc1ncnc(Cl)c1-c1ccc(Cl)cc1.OCCO.[K+]>>O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1",
        "output": "461"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)c1ccc(N(Cc2cn[nH]c2)C(=O)C2CCCc3c(OCc4ccccc4)cccc32)cn1.Cc1ccc(CCl)cc1.Cl>>Cc1ccc(Cn2cc(CN(C(=O)C3CCCc4c(OCc5ccccc5)cccc43)c3ccc(C(C)C)nc3)cn2)cc1",
        "output": "842"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(N)nc2)CC1.O=[N+]([O-])c1ccc(N2CCOCC2)cn1>>Nc1ccc(N2CCOCC2)cn1",
        "output": "457"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Cn1ccc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)c(Cl)c2)n1.ClCCl.O=C(O)C(F)(F)F>>CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2ccn(CC(=O)O)n2)cc1Cl",
        "output": "278"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CC1(C)OB(c2ccc3nc(N)c(N4CCOCC4)cc3c2)OC1(C)C.Cc1cnc(-c2cccc(C)c2Br)o1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>Cc1cnc(-c2cccc(C)c2-c2ccc3nc(N)c(N4CCOCC4)cc3c2)o1",
        "output": "933"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COCCOC.CSc1ccccc1Br.O=C([O-])[O-].OB(O)c1ccc2[nH]ccc2c1.[Na+].[Na+]>>CSc1ccccc1-c1ccc2[nH]ccc2c1",
        "output": "837"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cnc2c(c1)CCCC2NC(=S)NC(=O)c1ccccc1.Cl.[Na+].[OH-]>>Cc1cnc2c(c1)CCCC2NC(N)=S",
        "output": "80"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C[Si](C)(C)CCOCn1cc(C#N)c2c(N3CCC[C@H]3c3nn4ccc(Cl)c4c(=O)n3-c3ccccn3)ncnc21.O=C(O)C(F)(F)F>>N#Cc1c[nH]c2ncnc(N3CCC[C@H]3c3nn4ccc(Cl)c4c(=O)n3-c3ccccn3)c12",
        "output": "897"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.COC1CCNCC1.ClCCl.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)c(C(F)(F)F)c1>>COC1CCN(S(=O)(=O)c2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1",
        "output": "99"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccccc1SCC(F)(F)F.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>FC(F)(F)CSc1ccccc1CBr",
        "output": "29"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOP(=O)(OCC)C(F)(F)c1ccc(CC(=O)O)cc1.NC(=O)[C@H](Cc1ccc(C2=CC(=O)NS2(=O)=O)cc1)NC(=O)[C@@H](N)Cc1ccccc1.O=C(O)C(F)(F)F>>CCOP(=O)(OCC)C(F)(F)c1ccc(CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccc(C3=CC(=O)NS3(=O)=O)cc2)C(N)=O)cc1",
        "output": "133"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN.CN(C)CCn1ccc2c3nc(-c4ccc(N)cc4)nc(N4CCOCC4)c3ccc21.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CNC(=O)Nc1ccc(-c2nc(N3CCOCC3)c3ccc4c(ccn4CCN(C)C)c3n2)cc1",
        "output": "914"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CI.CN(C)C=O.O.OCCCCOc1ccccc1.[H-].[Na+]>>COCCCCOc1ccccc1",
        "output": "140"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCc1ccccc1.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].Oc1ccc(I)cc1.[K+].[K+].[Na+].[OH-]>>Ic1ccc(OCc2ccccc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1ccccc1-n1cnc(-c2ccccc2)n1.ClCCl>>Oc1ccccc1-n1cnc(-c2ccccc2)n1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[O-].CCCCO.COc1ccc(C2CN(C)Cc3cc(OCCCOS(C)(=O)=O)ccc32)cc1.Cl.FC1CCNCC1.O=C([O-])[O-].[Na+].[Na+].[Na+]>>COc1ccc(C2CN(C)Cc3cc(OCCCN4CCC(F)CC4)ccc32)cc1",
        "output": "496"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.Clc1ccccc1N1CCNCC1.FC(F)(F)c1nnc2ccc(Cl)nn12.O>>FC(F)(F)c1nnc2ccc(N3CCN(c4ccccc4Cl)CC3)nn12",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Fc1ccc(OCc2cn3cc(Br)cnc3n2)nc1.OB(O)c1ccc(F)cc1C(F)(F)F>>Fc1ccc(OCc2cn3cc(-c4ccc(F)cc4C(F)(F)F)cnc3n2)nc1",
        "output": "871"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.Cc1cc(Cl)ccc1N.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].O=C(c1cc(O)ccc1F)c1ccc(Br)cc1Cl.[Cs+].[Cs+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Cc1cc(Cl)ccc1Nc1ccc(C(=O)c2cc(O)ccc2F)c(Cl)c1",
        "output": "405"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CC(=O)c1ccc(OCc2ccccc2)cc1.ClC(Cl)Cl>>O=C(CBr)c1ccc(OCc2ccccc2)cc1",
        "output": "173"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(NC(=O)OCc1ccccc1)C(=O)O.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1cc2c(c3ccc(=O)[nH]c13)OC(CN)C2.Cl.c1ccncc1>>Cc1cc2c(c3ccc(=O)[nH]c13)OC(CNC(=O)C(C)(C)NC(=O)OCc1ccccc1)C2",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.ClCCl.N#CCC1(n2cc(C(N)=O)c(Nc3ccccc3)n2)C[NH2+]C1.O=C([O-])C(F)(F)F.c1ccncc1>>CC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1",
        "output": "369"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)Nc1ccc(B(O)O)cc1F.FC1(F)Oc2ccc(Br)cc2O1.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)OC(=O)Nc1ccc(-c2ccc3c(c2)OC(F)(F)O3)cc1F",
        "output": "837"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.CCOC(C)=O.C[C@H](O)c1ccccc1I.O=C([O-])[O-].OCCO.Sc1ccc2cc(Br)ccc2c1.[Cu]I.[K+].[K+]>>C[C@H](O)c1ccccc1Sc1ccc2cc(Br)ccc2c1",
        "output": "565"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CSCCN1.CN(C)C=O.O.O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(Br)cc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(N2CCSCC2)cc1",
        "output": "294"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=O)Cl.CCNc1cccc(C)c1>>CCC(=O)N(CC)c1cccc(C)c1",
        "output": "160"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Nc1cc(O)c(Br)cc1Br.CC(=O)[O-].Cl.O.[Na+]>>Nc1cc(O)c(Br)cc1Br",
        "output": "66"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)[C@]1(C(=O)N2CCN(c3cccc(C(F)(F)F)n3)CC2)CC[C@@H](N)C1.CC1COCCC1=O.CCN(CC)CC.Cl.Cl.ClCCl.O.[Na+]>>CC1COCCC1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cccc(C(F)(F)F)n3)CC2)(C(C)C)C1",
        "output": "236"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CNc1ccc(CN2CCCC2)cc1[N+](=O)[O-].Cl[Sn]Cl.O.O.O.O=C([O-])O.O=S(=O)([O-])O.[K+].[Na+]>>CNc1ccc(CN2CCCC2)cc1N",
        "output": "71"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)c1ccc(O)cc1.CN(C)C=O.O=C([O-])[O-].O=Cc1ccc(F)cc1.[K+].[K+]>>CC(C)(C)c1ccc(Oc2ccc(C=O)cc2)cc1",
        "output": "564"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCCCC1CCC(=O)Nc1cn2nc(-c3cnc(N)c(C(F)(F)F)c3)ccc2n1.Cl>>Nc1ncc(-c2ccc3nc(NC(=O)CCC4CCCCN4)cn3n2)cc1C(F)(F)F",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)Cl.Cc1ccccc1.Nc1cc(Br)ccc1C(=O)O>>CCOC(=O)Nc1cc(Br)ccc1C(=O)O",
        "output": "102"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(=O)(=O)c1ccc(-c2cn[nH]c(=O)c2Cc2ccc(F)cc2)cc1.Fc1ccc(Br)cc1Cl.N>>CS(=O)(=O)c1ccc(-c2cnn(-c3ccc(F)c(Cl)c3)c(=O)c2Cc2ccc(F)cc2)cc1",
        "output": "919"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(N2CCNCC2)CCOCC1.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc(C)c1O.F[B-](F)(F)F.O=C([O-])O.[Na+]>>Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCN(C3(C)CCOCC3)CC2)cc(C)c1O",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCN.CSc1ncc(-c2ccc(C)cc2C)c(=O)n1C>>CCCNc1ncc(-c2ccc(C)cc2C)c(=O)n1C",
        "output": "101"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCNC1Cc2ccccc2C1.ClCCl.O=C(Cl)c1ccccc1>>CCCN(C(=O)c1ccccc1)C1Cc2ccccc2C1",
        "output": "201"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2ccc([N+](=O)[O-])cc2)C(C)(C)C1.CCO.[Pd]>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(N)cc2)C(C)(C)C1",
        "output": "202"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)CC(=O)O.COCCOC.Cc1ccc(C)n1CCN.O=C(n1ccnc1)n1ccnc1>>Cc1ccc(C)n1CCNC(=O)CN(C)C",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.CCOCC.ClCCCBr>>ClCCCN1CCCC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC1CC(C(=O)Cl)C1.CCCCCCCCC1CC(C(=O)Cl)C1.CCCCCCCOc1ccc(-c2ccc(O)c(F)c2)cc1F>>CCCCCCCOc1ccc(-c2ccc(OC(=O)C3CC(CC)C3)c(F)c2)cc1F",
        "output": "111"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCBr.CCOC(C)=O.CN(C)C=O.CNC(=O)c1nc(-c2cccc(O)c2)cnc1N.O=C([O-])[O-].[Cs+].[Cs+]>>CNC(=O)c1nc(-c2cccc(OCCBr)c2)cnc1N",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.COC(=O)c1ccc(CCC(/C=C/c2ccccc2OCCCCBr)Cc2ccc(C#N)cc2)cc1.O=C([O-])[O-].Oc1ccc(C(F)(F)F)cc1.[K+].[K+]>>COC(=O)c1ccc(CCC(/C=C/c2ccccc2OCCCCOc2ccc(C(F)(F)F)cc2)Cc2ccc(C#N)cc2)cc1",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O.O=C(O)c1ccncc1.O=C([O-])O.O=S(=O)(O)O.[Na+]>>CCOC(=O)c1ccncc1",
        "output": "33"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CCc1cccc([N+](=O)[O-])c1OCC#CC.CC(=O)O.[Fe]>>C=CCc1cccc(N)c1OCC#CC",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OCC1CCC(n2cc(C)c(=O)[nH]c2=O)OC1.CO.N>>Cc1cn(C2CCC(CO)CO2)c(=O)[nH]c1=O",
        "output": "225"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)c1ccc(N=C=O)cc1.CCn1cc(-c2cccc(N)c2)c(-c2ccncc2)n1.ClCCl>>CCn1cc(-c2cccc(NC(=O)Nc3ccc(C(C)(C)C)cc3)c2)c(-c2ccncc2)n1",
        "output": "473"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COCCOC.Cc1ccccc1.N#Cc1c(O)c2c(-c3ccc(Br)cc3)csc2[nH]c1=O.O.O=C([O-])[O-].OB(O)c1ccc(F)cc1.[Cs+].[Cs+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1c(O)c2c(-c3ccc(-c4ccc(F)cc4)cc3)csc2[nH]c1=O",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C(C)(C)Br.CN(C)C=O.O.O=C([O-])[O-].Oc1ccccc1.[Cs+].[Cs+]>>CCOC(=O)C(C)(C)Oc1ccccc1",
        "output": "305"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CSc1ccc([N+](=O)[O-])cc1.ClCCl.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1ccc([N+](=O)[O-])cc1",
        "output": "500"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C(=O)OC(C)(C)C)n1cc(OC)c(-c2cc(Cl)ccc2C#N)cc1=O.ClCCl.O=C(O)C(F)(F)F>>CCC(C(=O)O)n1cc(OC)c(-c2cc(Cl)ccc2C#N)cc1=O",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(CO)COC(c2ccc(Cl)nc2)=N1.CC1CCCN1CCCO.CCOC(C)=O.CN(C)C=O.[H-].[Na+]>>CC1CCCN1CCCOc1ccc(C2=NC(C)(CO)CO2)cn1",
        "output": "433"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NC1CCN(Cc2ccccc2)CC1.CCO.[Pd]>>CC(C)(C)OC(=O)NC1CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)c1cccc(C(C)C)c1NC(=O)C1c2ccccc2COc2ccc(C(=O)O)cc21.CCN(CC)CC.CCOC(=O)Cl.[BH4-].[Cl-].[Na+].[Na+]>>CC(C)c1cccc(C(C)C)c1NC(=O)C1c2ccccc2COc2ccc(CO)cc21",
        "output": "72"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3F)cc2[nH]c1=O.COCCN>>COCCNC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3F)cc2[nH]c1=O",
        "output": "498"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cc1ccc(S(=O)(=O)[O-])cc1.Cc1nn(CC[C@](C)(C(=O)NOC2CCCCO2)S(C)(=O)=O)cc1-c1ccccc1.c1cc[nH+]cc1>>Cc1nn(CC[C@](C)(C(=O)NO)S(C)(=O)=O)cc1-c1ccccc1",
        "output": "915"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)[C@H](Cc1ccc(-c2ncc(Br)cn2)cc1)NC(=O)c1ccc(C(C)(C)C)s1.ClCCl.O=C(O)C(F)(F)F>>CC(C)(C)c1ccc(C(=O)N[C@@H](Cc2ccc(-c3ncc(Br)cn3)cc2)C(=O)O)s1",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "N.O.O=P(Cl)(Cl)Cl.O=c1ccc2cccc(Br)c2[nH]1>>Clc1ccc2cccc(Br)c2n1",
        "output": "100"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.C[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.ClCCl.Nc1ccc(F)cc1Nc1ccncn1.On1nnc2cccnc21>>C[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc(F)cc1Nc1ccncn1",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cccc(-c2ocnc2C(=O)Nc2cnn(CC3CCCN3C(=O)OC(C)(C)C)c2)c1.ClCCl.O=C(O)C(F)(F)F>>Cc1cccc(-c2ocnc2C(=O)Nc2cnn(CC3CCCN3)c2)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.Cc1cc(-n2ccc3oc(-c4cccc(Cl)c4)cc3c2=O)ccc1[N+](=O)[O-].O.[Cl-].[Fe].[NH4+]>>Cc1cc(-n2ccc3oc(-c4cccc(Cl)c4)cc3c2=O)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCBr.CN(C)C=O.Cc1c(C(F)(F)F)cnn(-c2cc(O)c(Cl)cc2F)c1=O.O.O=C([O-])[O-].[K+].[K+]>>C#CCOc1cc(-n2ncc(C(F)(F)F)c(C)c2=O)c(F)cc1Cl",
        "output": "154"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CC(c2nccnc2Cl)C1.Cl[Pd]Cl.O.O=P([O-])([O-])[O-].OB(O)c1ccccc1O.[Fe+2].[K+].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(C)OC(=O)N1CC(c2nccnc2-c2ccccc2O)C1",
        "output": "875"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCOCC(O)(c2ccc(Cl)c(Cl)c2)C1.CCI>>CCOC1(c2ccc(Cl)c(Cl)c2)COCCN(C(=O)OC(C)(C)C)C1",
        "output": "307"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C(=O)O)CC1.CCN(C(C)C)C(C)C.CNOC.Cl.ClCCCl.ClCCl.On1nnc2cccnc21>>CON(C)C(=O)[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1",
        "output": "54"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COc1ccc(-c2cc(C#N)c3[nH]c4cc(OC)ccc4c3c2)cc1.O=C([O-])[O-].OO.[Na+].[Na+].[Na+].[OH-]>>COc1ccc(-c2cc(C(N)=O)c3[nH]c4cc(OC)ccc4c3c2)cc1",
        "output": "677"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[O-].Cl.Nc1c(C(=O)O)cccc1C(F)(F)F.O.O=N[O-].[N-]=[N+]=[N-].[Na+].[Na+].[Na+]>>[N-]=[N+]=Nc1c(C(=O)O)cccc1C(F)(F)F",
        "output": "189"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCC.C[C@H]1CN(Cc2ccccc2)C[C@H]1C#N.O=C([O-])O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+]>>C[C@H]1CN(Cc2ccccc2)C[C@H]1CN",
        "output": "246"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.COc1cccc(CCCCCCC(O[Si](C)(C)C(C)(C)C)c2ncc(I)o2)c1.[F-]>>COc1cccc(CCCCCCC(O)c2ncc(I)o2)c1",
        "output": "708"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC1(C)C(C(=O)O)C1(C)C.CCN(CC)CC.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.Cl.Nc1nc2ccc(F)cc2s1.On1nnc2ccccc21>>CC1(C)C(C(=O)Nc2nc3ccc(F)cc3s2)C1(C)C",
        "output": "681"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCC(=O)Nc1ccc2c(c1)Cc1cc(NC(=O)OC(C)(C)C)ccc1-2.ClCCl.O=C(O)C(F)(F)F>>CCCC(=O)Nc1ccc2c(c1)Cc1cc(N)ccc1-2",
        "output": "782"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.COc1cc(C2CCN(C(=O)OC(C)(C)C)CC2)ccc1C#N.Cl.ClCCl>>COc1cc(C2CCNCC2)ccc1C#N",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)Cc1cc(C)c(C(=O)c2ccc(Cl)cc2Cl)n1C.[Na+].[OH-]>>Cc1cc(CC(=O)O)n(C)c1C(=O)c1ccc(Cl)cc1Cl",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Cc1cc(OCc2ccccc2)cc(C)c1CC(=O)OCc1ccccc1.O.[Na+].[OH-]>>Cc1cc(OCc2ccccc2)cc(C)c1CC(=O)O",
        "output": "186"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)Nc1cccnc1N1CCNCC1.CCN=C=NCCCN(C)C.CN(C)c1ccc2cc(C(=O)O)[nH]c2c1>>CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3ccc(N(C)C)cc3[nH]2)CC1",
        "output": "605"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)[O-].CC(C)N(CCCCO)C(=O)OC(C)(C)C.ClCCl.Fc1ccccc1CBr.[K+]>>CC(C)N(CCCCOCc1ccccc1F)C(=O)OC(C)(C)C",
        "output": "464"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1csc2nc(-c3ccno3)nc(Cl)c12.NCCc1ccc2c(c1)OCO2>>Cc1csc2nc(-c3ccno3)nc(NCCc3ccc4c(c3)OCO4)c12",
        "output": "723"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CSCCN1.CCN(C(C)C)C(C)C.CN1CCCC1=O.COCCc1noc(C2CC(c3ccc(CC(F)F)cc3)CN(C(=O)Oc3ccc([N+](=O)[O-])cc3)C2)n1>>COCCc1noc(C2CC(c3ccc(CC(F)F)cc3)CN(C(=O)N3CCSCC3)C2)n1",
        "output": "770"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOCC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.Nc1ccc(Cl)cc1Cl.O.O=C(O)c1cc[nH]n1>>O=C(Nc1ccc(Cl)cc1Cl)c1cc[nH]n1",
        "output": "844"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)Nc1nc(Cl)c(C#N)c(Cl)n1.CCNCC.CCOCC>>CCN(CC)c1nc(NC(C)C)nc(Cl)c1C#N",
        "output": "296"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CCO.CCOCC.Cl.Cl.ClCCl.O=C(Cl)c1ccc(CCN2CCN(Cc3ccccc3Cl)CC2)cc1>>CCN(CC)CCOC(=O)c1ccc(CCN2CCN(Cc3ccccc3Cl)CC2)cc1",
        "output": "51"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.N#Cc1ccc(CBr)cc1.O=C1N(C2CCOCC2)C[C@@H](c2ccccc2)N1C1CCNCC1>>N#Cc1ccc(CN2CCC(N3C(=O)N(C4CCOCC4)C[C@H]3c3ccccc3)CC2)cc1",
        "output": "248"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.ClCc1ccc(Cl)nc1.Oc1ccc(Oc2cccc(C(F)(F)F)c2)cc1Cl.[H-].[Na+]>>FC(F)(F)c1cccc(Oc2ccc(OCc3ccc(Cl)nc3)c(Cl)c2)c1",
        "output": "678"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC.CCCCCC(=O)O.CCCCCCCCOc1ccc(-c2ccc(C(C)O)cc2)cc1.CN(C)c1ccncc1.ClCCl>>CCCCCCCCOc1ccc(-c2ccc(C(C)OC(=O)CCCCC)cc2)cc1",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Cc1ccccc1.O=[Mn]=O.OCc1cnc2sc3ccccc3n12>>O=Cc1cnc2sc3ccccc3n12",
        "output": "287"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OCc1nc(C)c(C(C)C)c(O)n1.O=P(Cl)(Cl)Cl>>CC(=O)OCc1nc(C)c(C(C)C)c(Cl)n1",
        "output": "25"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COC(=O)c1ccc(C#C[Si](C)(C)C)cc1.[F-]>>C#Cc1ccc(C(=O)OC)cc1",
        "output": "337"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.N#Cc1ccc(-c2ccnc(Cl)c2Br)cc1.NN>>N#Cc1ccc(-c2ccnc(NN)c2Br)cc1",
        "output": "417"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.C[O-].Cl.Cl.NC1CCN(CCn2c(=O)cnc3ccc(F)cc32)CC1.[Cl-].[NH4+].[Na+]>>COc1ccc2ncc(=O)n(CCN3CCC(N)CC3)c2c1",
        "output": "636"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.Nc1nc(I)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O.O=C([O-])[O-].[Na+].[Na+].[O-][Cl+3]([O-])([O-])O>>CC1(C)O[C@@H]2[C@@H](CO)O[C@@H](n3cnc4c(N)nc(I)nc43)[C@@H]2O1",
        "output": "265"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CN.O.O=C(O)[C@H]1CC[C@@H](Nc2nc(Cl)nc(Cl)n2)CC1.[Na+].[OH-]>>CNc1nc(Cl)nc(N[C@@H]2CC[C@H](C(=O)O)CC2)n1",
        "output": "578"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)NC1CCN(Cc2ccccc2)CC1(C)C.CO.[H][H].[OH-].[OH-].[Pd+2]>>CCOC(=O)NC1CCNCC1(C)C",
        "output": "84"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCN(CC[C@H](N)c3ccccc3)CC2)c1.O=C=Nc1ccc(Cl)c(Cl)c1>>CC(C)C(=O)Nc1cccc(C2CCN(CC[C@H](NC(=O)Nc3ccc(Cl)c(Cl)c3)c3ccccc3)CC2)c1",
        "output": "814"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)CCc1cccc2ccccc12.CCOC(C)=O.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCc1cccc2ccccc12",
        "output": "225"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)C(=O)CC(=O)c1ccc(Cc2ccccc2)c(OC)c1OCCOC.CO.O.[Na+].[OH-]>>COCCOc1c(C(=O)CC(=O)C(=O)O)ccc(Cc2ccccc2)c1OC",
        "output": "472"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1ccc(C(=O)N[C@@H](Cc2ccc(-c3ncc(Br)cn3)cc2)C(=O)O)s1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)[C@H]1CCNC1.F[P-](F)(F)(F)(F)F.O=C([O-])C1CCNC1>>COC(=O)[C@H]1CCN(C(=O)[C@H](Cc2ccc(-c3ncc(Br)cn3)cc2)NC(=O)c2ccc(C(C)(C)C)s2)C1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)CCC(OC)OC.Cl.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1>>COC(CCC(=O)N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1)OC",
        "output": "392"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.COC(=O)c1ccccc1SCCNC1CCN(CCn2c(=O)cc(C)c3ccc(OC)cc32)CC1.[Na+].[OH-]>>COc1ccc2c(C)cc(=O)n(CCN3CCC(NCCSc4ccccc4C(=O)O)CC3)c2c1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.C[Si](C)(C)CCOCCl.Fc1cnc2[nH]ccc2c1I.[H-].[Na+]>>C[Si](C)(C)CCOCn1ccc2c(I)c(F)cnc21",
        "output": "712"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC(=O)Cl.ClCCl.Nc1cnc2ccccc2c1Cl>>CCOCC(=O)Nc1cnc2ccccc2c1Cl",
        "output": "422"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CO.O.O=C([O-])[O-].OC[C@@H]1CCC2(C[C@H]1COCc1ccccc1)OCCO2.[K+].[K+]>>O=C1CC[C@@H](CO)[C@H](COCc2ccccc2)C1",
        "output": "251"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCOCC.ClCCCBr.[Na+].[OH-].c1ccc2nc(N3CCNCC3)ccc2c1>>ClCCCN1CCN(c2ccc3ccccc3n2)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.NCCc1ccc(Cl)c(Cl)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(NCCc1ccc(Cl)c(Cl)c1)C(F)(F)F",
        "output": "316"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCO.CN(C)c1cc(Cl)nc2ccccc12.N[C@H]1CC[C@@H](CNC(=O)OCc2ccccc2)CC1.O=C([O-])O.[Na+]>>CN(C)c1cc(N[C@H]2CC[C@@H](CNC(=O)OCc3ccccc3)CC2)nc2ccccc12",
        "output": "70"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCOC(=O)c1nc2cccnc2n(-c2ccccc2)c1=O.Cl>>O=C(O)c1nc2cccnc2n(-c2ccccc2)c1=O",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)CS(=O)(=O)Cl.CCN(C(C)C)C(C)C.CS(=O)(=O)c1ccc(OCc2csc(N3CCNCC3)n2)cc1.Cl.ClCCl>>CC(C)CS(=O)(=O)N1CCN(c2nc(COc3ccc(S(C)(=O)=O)cc3)cs2)CC1",
        "output": "584"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N1CCC(NC2CCCNC2Cc2ccccc2)CC1.CC(Cl)Cl.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.O=C(Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CC(=O)N1CCC(NC2CCCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2Cc2ccccc2)CC1",
        "output": "201"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=C(O)C1C(C(=O)Nc2ccc(-n3ccccc3=O)cc2F)C1c1ccccc1.O=S(Cl)Cl>>COC(=O)C1C(C(=O)Nc2ccc(-n3ccccc3=O)cc2F)C1c1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCOC(=O)CBr.CN1CCNCC1CO.Cl.Cl.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CN1CCN(C)C(CO)C1",
        "output": "467"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCNCC1.O=C(CCl)Nc1ccc2c(c1)COC(NC1COc3cc(F)ccc31)=N2>>CN1CCN(CC(=O)Nc2ccc3c(c2)COC(NC2COc4cc(F)ccc42)=N3)CC1",
        "output": "340"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)n1ncc(-c2nc(CC(=O)O)cs2)c1-c1ccc(F)cc1.CNCCOC>>COCCN(C)C(=O)Cc1csc(-c2cnn(C(C)(C)C)c2-c2ccc(F)cc2)n1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCS(=O)(=O)Cl.Clc1cc(NC2CCCC2)c2[nH]c(C3=N[C@H](CCN4CCNCC4)CS3)cc2c1>>CCS(=O)(=O)N1CCN(CC[C@@H]2CSC(c3cc4cc(Cl)cc(NC5CCCC5)c4[nH]3)=N2)CC1",
        "output": "584"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O=C(c1ccccc1)C1CCN(Cc2nc3cc(O)ccc3[nH]2)CC1.[BH4-].[Na+]>>Oc1ccc2[nH]c(CN3CCC(C(O)c4ccccc4)CC3)nc2c1",
        "output": "24"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(CC)(c1ccc(CCC(O)C(C)(C)C)c(C)c1)c1ccc(-c2ccc(CC(=O)OC)cc2)c(C)c1.CO.Cl.[Na+].[OH-]>>CCC(CC)(c1ccc(CCC(O)C(C)(C)C)c(C)c1)c1ccc(-c2ccc(CC(=O)O)cc2)c(C)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O.Cc1cc(-c2ccc3c(c2)CCNCC3)n(C)n1.ClCCCBr>>Cc1cc(-c2ccc3c(c2)CCN(CCCCl)CC3)n(C)n1",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2C(C)(C)COC.ClCCl.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OS(=O)(=O)C(F)(F)F)cc1CC2C(C)(C)COC",
        "output": "843"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O.O=C(c1ccc(F)cc1)c1ccc(Cl)cc1Cl.[BH4-].[Na+]>>OC(c1ccc(F)cc1)c1ccc(Cl)cc1Cl",
        "output": "157"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCSc1ccc(B(O)O)cc1.COc1ccc(OCC(=O)OC(C)(C)C)c(Br)c1>>CCSc1ccc(-c2cc(OC)ccc2OCC(=O)OC(C)(C)C)cc1",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)n1nc(NC(=O)c2cccc(Cl)c2)c2cc(NC(=O)NCc3cc(F)ccc3F)ccc21.Cl>>O=C(NCc1cc(F)ccc1F)Nc1ccc2[nH]nc(NC(=O)c3cccc(Cl)c3)c2c1",
        "output": "896"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Fc1cccc(OC(F)(F)F)c1.O=S(=O)(O)O.O=[N+]([O-])O>>O=[N+]([O-])c1ccc(F)cc1OC(F)(F)F",
        "output": "21"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOCC.COc1ccc(CC(N)C(=O)NCCCCc2ccccc2)c2ccn(S(=O)(=O)c3ccccc3)c12.ClCCl.O=S(=O)(Cl)c1ccccc1.[Cl-]>>COc1ccc(CC(NS(=O)(=O)c2ccccc2)C(=O)NCCCCc2ccccc2)c2ccn(S(=O)(=O)c3ccccc3)c12",
        "output": "596"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cl.ClCCl.Cn1nc(-c2cnc3c(n2)c(C(=O)NC2CCC(N)C2)cn3COCC[Si](C)(C)C)c2ccc(Cl)cc21>>Cn1nc(-c2cnc3c(n2)c(C(=O)NC2CCC(NS(C)(=O)=O)C2)cn3COCC[Si](C)(C)C)c2ccc(Cl)cc21",
        "output": "493"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccccc1B(O)O.Clc1nc(Nc2cc[nH]n2)cc2ccccc12>>COc1ccccc1-c1nc(Nc2cc[nH]n2)cc2ccccc12",
        "output": "865"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1cnc(Cl)cc1C(F)(F)F.Nc1cccc(Cl)c1>>COC(=O)c1cnc(Nc2cccc(Cl)c2)cc1C(F)(F)F",
        "output": "434"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Cc1c(OC2CCN(C(=O)OC(C)(C)C)C2)cccc1[N+](=O)[O-].[Pd]>>Cc1c(N)cccc1OC1CCN(C(=O)OC(C)(C)C)C1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrP(Br)Br.ClCCl.O=C([O-])O.OCCc1ccc(Cl)cc1Cl.[Na+]>>Clc1ccc(CCBr)c(Cl)c1",
        "output": "301"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.Cc1ccc([N+](=O)[O-])c(C)c1C=O.Cc1ccccc1.O.OCCO>>Cc1ccc([N+](=O)[O-])c(C)c1C1OCCO1",
        "output": "117"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1cc2cc(O)c(Cl)c(Cl)c2s1.CCC(C)=O.CCOC(=O)CBr.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)COc1cc2cc(C(C)=O)sc2c(Cl)c1Cl",
        "output": "123"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)c1ccncc1.COc1ccc(-c2cncc(N)c2)cc1.O=S(=O)(Cl)c1cc(Cl)ccc1OC(F)(F)F.c1ccncc1>>COc1ccc(-c2cncc(NS(=O)(=O)c3cc(Cl)ccc3OC(F)(F)F)c2)cc1",
        "output": "554"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)N.C[Si](C)(C)CCOCn1cc(C(=O)O)c2nc(-c3nn(CC(=O)N4CCOCC4)c4cc(F)ccc34)cnc21.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(CC(=O)N4CCOCC4)c4cc(F)ccc34)nc12",
        "output": "737"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)C[C@@H](CO)Nc1ccc(C#N)c(Cl)c1.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>Cc1ccc(S(=O)(=O)OC[C@H](CC(=O)OC(C)(C)C)Nc2ccc(C#N)c(Cl)c2)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CN(C)CCC(=O)c1ccc(OCCCN2CCCCC2)cc1.O.[BH4-].[Na+]>>CN(C)CCC(O)c1ccc(OCCCN2CCCCC2)cc1",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCC.CCOC(C)=O.COc1ccc(C=O)c(OC)c1OC.Cl.ClB(Cl)Cl.ClCCl.O=C([O-])O.[Na+]>>COc1ccc(C=O)c(O)c1O",
        "output": "19"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCNCC4)cc3)nc2c1.Fc1ccc(CBr)cc1.O.O=C([O-])[O-].[K+].[K+]>>COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCN(Cc5ccc(F)cc5)CC4)cc3)nc2c1",
        "output": "248"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN.CO.COC(=O)C1CC(=O)N(Cc2ccccc2)C1>>CCNC(=O)C1CC(=O)N(Cc2ccccc2)C1",
        "output": "392"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COCCl.Cc1cc2c(cc1-c1ccc(O)c(C=O)c1)C(C)(C)CCC2(C)C>>COCOc1ccc(-c2cc3c(cc2C)C(C)(C)CCC3(C)C)cc1C=O",
        "output": "375"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.ClCCl.NCCNc1nc(Cl)nc2c1ncn2C1CCCC1.O.O=S(=O)(Cl)c1ccc(Cl)cc1>>O=S(=O)(NCCNc1nc(Cl)nc2c1ncn2C1CCCC1)c1ccc(Cl)cc1",
        "output": "43"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)CCOc1ccccc1F.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C1CCOc2c(F)cccc21",
        "output": "274"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.CC(C)(C)OC(=O)c1cc(Cl)ccn1.O.O=C([O-])[O-].Oc1ccc2nc(Nc3ccccc3N3CCOCC3)ncc2c1.[Cs+].[Cs+]>>CC(C)(C)OC(=O)c1cc(Oc2ccc3nc(Nc4ccccc4N4CCOCC4)ncc3c2)ccn1",
        "output": "351"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1ccc(N)cc1.Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CC=O)c2cc1C>>CC(=O)Nc1ccc(NCCn2c3nc(=O)[nH]c(=O)c-3nc3cc(C)c(C)cc32)cc1",
        "output": "336"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(CCCO[Si](C)(C)C(C)(C)C)NC(=O)OC(C)(C)C.CI.CN(C)C=O.[H-].[H][H].[Na+]>>CN(C(=O)OC(C)(C)C)C(C)(C)CCCO[Si](C)(C)C(C)(C)C",
        "output": "803"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc(C(=O)CC(Cc2ccc(N)cc2)NC(=O)[C@@H]2CCCN2)cc(OC)c1OC.O=C(Cl)OCc1ccccc1>>COc1cc(C(=O)CC(Cc2ccc(NC(=O)OCc3ccccc3)cc2)NC(=O)[C@@H]2CCCN2)cc(OC)c1OC",
        "output": "509"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(=O)O.COC(=O)C(CSc1cnc(NC(=O)Nc2ccc(C)cc2C(=O)C2CCCC2)s1)NC(C)=O>>CC(=O)NC(CSc1cnc(NC(=O)Nc2ccc(C)cc2C(=O)C2CCCC2)s1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.COCC(=O)Cl.COc1c(C(=O)N(C)CCN)sc2c1c(=O)n(CC(=O)c1ccccc1)c1ccccc21.Cl.O=C([O-])O.[Na+]>>COCC(=O)NCCN(C)C(=O)c1sc2c(c1OC)c(=O)n(CC(=O)c1ccccc1)c1ccccc21",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C(=O)O)c1ccc2cc(CO)ccc2c1.CI.COC(=O)C(C)c1ccc2cc(CO)ccc2c1.Cl.[H-].[Na+].c1ccccc1>>COCc1ccc2cc(C(C)C(=O)OC)ccc2c1",
        "output": "140"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.Nc1ncccc1Br.O=C(CBr)c1ccc(O)cc1>>Oc1ccc(-c2cn3cccc(Br)c3n2)cc1",
        "output": "508"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Clc1cccc(CBr)c1.O.O=C([O-])[O-].O=S(=O)(c1cccc2ccccc12)c1n[nH]c2c(OCCCl)cccc12.[Cs+].[Cs+]>>O=S(=O)(c1cccc2ccccc12)c1nn(Cc2cccc(Cl)c2)c2c(OCCCl)cccc12",
        "output": "635"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCCCN(CC(=O)O)S(=O)(=O)c1ccc(C)cc1.CN(C)C=O.CN1CCOCC1.Cl.ClCCCl.NOCc1ccccc1.On1nnc2ccccc21>>CCCCCCCCN(CC(=O)NOCc1ccccc1)S(=O)(=O)c1ccc(C)cc1",
        "output": "480"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COC(=O)c1ccccc1F.NN.O>>NNC(=O)c1ccccc1F",
        "output": "421"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCc1ccccc1.CC(C)(C)OC(=O)n1ccc(CCCC(=O)O)n1.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)n1ccc(CCCC(=O)OCc2ccccc2)n1",
        "output": "403"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CN1CCN(C(=O)OC(C)(C)C)CC1.CO.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCN(CC(=O)O)CC1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)C(Cc1ccc(OCCNC(=O)c2ccc(-c3ccccc3)cc2)cc1)Oc1ccccc1.[Na+].[OH-]>>O=C(NCCOc1ccc(CC(Oc2ccccc2)C(=O)O)cc1)c1ccc(-c2ccccc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1ccc(-c2cccc3cncn23)cc1.[Na+].[OH-]>>O=C(O)c1ccc(-c2cccc3cncn23)cc1",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)CCC[N+](=O)[O-].Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.N#N.O=C([O-])O.OCCO.[Na+]>>CC1(CCC[N+](=O)[O-])OCCO1",
        "output": "265"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)S(=O)(=O)c1ccc(Cl)nc1.CCO.NN.O>>CCN(CC)S(=O)(=O)c1ccc(NN)nc1",
        "output": "417"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.CN(C)C=O.Cc1cc2[nH]cc(C)c2cc1Br.[Li]C(C)(C)C>>Cc1cc2[nH]cc(C)c2cc1C=O",
        "output": "638"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(CC)(c1ccc(Cl)cc1)n1ccc2c(N)cccc21.CN1CCOCC1.CS(=O)(=O)Cl.ClCCl.O>>CCC(CC)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cccc21",
        "output": "194"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C=C(C(=O)O)N(CC)S(=O)(=O)c1ccc(Cl)cc1.CCOC(=O)OC(=O)OCC.NCc1cc(-c2ccc(C(F)(F)F)cc2)nc(N2CCCC2)c1>>C=C(C(=O)NCc1cc(-c2ccc(C(F)(F)F)cc2)nc(N2CCCC2)c1)N(CC)S(=O)(=O)c1ccc(Cl)cc1",
        "output": "549"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1NCCc2ccc(-c3cn[nH]c3)cc21.O=C(O)c1cc2ncc(Br)cn2n1>>CC1c2cc(-c3cn[nH]c3)ccc2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "952"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cn(C(CC2CCOC2)C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N.O=C(O)C(F)(F)F>>COc1cn(C(CC2CCOC2)C(=O)Nc2ccc(C(=O)O)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N",
        "output": "752"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CNOC.Cl.Cl.O=C(O)Cc1cccnc1.On1nnc2ccccc21>>CON(C)C(=O)Cc1cccnc1",
        "output": "54"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(S(=O)(=O)n2ccc(/C=C/C(=O)Nc3ccccc3NC(=O)OC(C)(C)C)c2)cc1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(S(=O)(=O)n2ccc(/C=C/C(=O)Nc3ccccc3N)c2)cc1",
        "output": "782"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cc1ccc(S(=O)(=O)O)cc1.O.O=C(O)Cc1ccc(O)cc1>>CCOC(=O)Cc1ccc(O)cc1",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O.O=C(NC1(C(=O)O)CC1)OCc1ccccc1.O=C([O-])O.[NH4+]>>NC(=O)C1(NC(=O)OCc2ccccc2)CC1",
        "output": "313"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc2c(ccn2S(=O)(=O)c2ccccc2)c1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>O=S(=O)(c1ccccc1)n1ccc2cc(CBr)ccc21",
        "output": "29"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cn1c(CN2CCC(C(C)(C)O)CC2)nc2c(N3CCOCC3)nc(Nc3cccc(F)c3[N+](=O)[O-])nc21.[Pd]>>Cn1c(CN2CCC(C(C)(C)O)CC2)nc2c(N3CCOCC3)nc(Nc3cccc(F)c3N)nc21",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#Cc1cccc2c(=O)[nH]c(-c3ccc(CN4CCN(C(=O)OC(C)(C)C)CC4)cc3)cc12.C1COCCO1.Cl.ClCCl>>C#Cc1cccc2c(=O)[nH]c(-c3ccc(CN4CCNCC4)cc3)cc12",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCP(CCCC)CCCC.CCOCC.COc1cc2c(Oc3ccc(Cl)cc3F)ncnc2cc1O.ClCCl.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.O=S1(=O)CCN(CCCO)CC1>>COc1cc2c(Oc3ccc(Cl)cc3F)ncnc2cc1OCCCN1CCS(=O)(=O)CC1",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CNC1.CC(C)(C)C(NC(=O)c1cc(OCC(F)(F)F)c(C2CC2)cn1)C(=O)O.O=C([O-])[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C([O-])[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.[Mg+2]>>CC(C)(C)C(NC(=O)c1cc(OCC(F)(F)F)c(C2CC2)cn1)C(=O)N1CCC1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCCC.Fc1cccc(-c2cc(N3CCNCC3)ncn2)c1F.O=C(Nc1cccnc1)OCC(Cl)(Cl)Cl>>O=C(Nc1cccnc1)N1CCN(c2cc(-c3cccc(F)c3F)ncn2)CC1",
        "output": "980"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(CN)CCN(C(=O)OC(C)(C)C)CC1.CCN(C(C)C)C(C)C.ClCCl.O=C(Cl)c1ccc(Cl)cc1>>CC1(CNC(=O)c2ccc(Cl)cc2)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "271"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)O)(CC1)CC2.NCc1cccs1>>N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)NCc3cccs3)(CC1)CC2",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.O.OC1(c2ccccc2)CCNCC1>>CC(C)(C)OC(=O)N1CCC(O)(c2ccccc2)CC1",
        "output": "694"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2nc(OC3CCC(O)C3)c3ccccc3n2)CC1.O=C(O)C(F)(F)F>>OC1CCC(Oc2nc(N3CCNCC3)nc3ccccc23)C1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=CC(=O)Cl.CCCCCC.ClCCl.NCCNCCN>>C=CC(=O)N(CCN)CCN",
        "output": "135"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N1CCNC[C@H]1C.CC(C)C1=C(C(=O)N2[C@@H](C#N)CC[C@H]2C(=O)O)SC2=N[C@@](C)(c3ccc(Cl)cc3)[C@@H](c3ccc(Cl)cc3)N21>>CC(=O)N1CCN(C(=O)[C@@H]2CC[C@H](C#N)N2C(=O)C2=C(C(C)C)N3C(=N[C@@](C)(c4ccc(Cl)cc4)[C@H]3c3ccc(Cl)cc3)S2)C[C@H]1C",
        "output": "685"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1cnc(OC)c(F)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1ncc(CO)cc1F",
        "output": "522"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.COC(=O)Cc1cccc(C)c1.ClC(Cl)(Cl)Cl.O=C([O-])O.O=C1CCC(=O)N1Br.[Na+]>>COC(=O)Cc1cccc(CBr)c1",
        "output": "29"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.Nc1ccccc1.O=C(O)c1cccc(S(=O)(=O)Cl)c1>>O=C(O)c1cccc(S(=O)(=O)Nc2ccccc2)c1",
        "output": "68"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(OCC)[C@H](C)N(Cc1cccc2ccccc12)C(=O)[C@@H](N)Cc1ccc(OC(C)(C)C)cc1.O=C(O)CONC(=O)NCc1ccc(Cl)cc1>>CCOC(OCC)[C@H](C)N(Cc1cccc2ccccc12)C(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)CONC(=O)NCc1ccc(Cl)cc1",
        "output": "133"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)c1ccc(-n2ccc([N+](=O)[O-])n2)nc1.CCOC(C)=O.[Pd]>>CC(C)(C)OC(=O)c1ccc(-n2ccc(N)n2)nc1",
        "output": "684"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2cnc(N)c(Br)c2)C1.ClCCl.O=C(O)C(F)(F)F>>Nc1ncc(C2CCNC2)cc1Br",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.COC(=O)NC(C)(CCCc1ccc(Sc2cccc(C(F)(F)F)c2)cc1Cl)C(=O)[O-].O=C(O)CC(O)(CC(=O)O)C(=O)O.[BH4-].[Li+]>>COC(=O)NC(C)(CO)CCCc1ccc(Sc2cccc(C(F)(F)F)c2)cc1Cl",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Nc1cccc(F)c1.O=C(O)c1cc(Br)ccc1OCc1ccccc1.O=C(n1ccnc1)n1ccnc1>>O=C(Nc1cccc(F)c1)c1cc(Br)ccc1OCc1ccccc1",
        "output": "50"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.Cl.NO.O=C([O-])O.O=C1CCC(c2cc(-c3ccccc3Cl)c3c(c2)N(c2c(Cl)cccc2Cl)C(=O)NC3)CC1.[Na+]>>O=C1NCc2c(-c3ccccc3Cl)cc(C3CCC(=NO)CC3)cc2N1c1c(Cl)cccc1Cl",
        "output": "86"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.NN.O.O.O=C1c2ccccc2C(=O)N1C[C@H](Nc1cncc(Br)c1)c1ccccc1>>NC[C@H](Nc1cncc(Br)c1)c1ccccc1",
        "output": "242"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCC(=O)Cl.CCN(CC)CC.CCOC(C)=O.NC1CCc2c(Br)cncc21.O>>CCC(=O)NC1CCc2c(Br)cncc21",
        "output": "45"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.CCOC(=O)CCCOc1ccc(-c2nnc(-c3ccc(OC(C)C)c(C#N)c3)s2)c(CC)c1.O.[Na+].[OH-]>>CCc1cc(OCCCC(=O)O)ccc1-c1nnc(-c2ccc(OC(C)C)c(C#N)c2)s1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)CN.COc1ccc(-n2nc(C(=O)O)cc2-c2cnccn2)nn1>>COc1ccc(-n2nc(C(=O)NCC(C)(C)C)cc2-c2cnccn2)nn1",
        "output": "816"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.CN(C)C=O.NC[C@@H]1C[C@@H](n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc32)C1>>CC(=O)NC[C@@H]1C[C@@H](n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc32)C1",
        "output": "339"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)N(C)C.CCN(C(C)C)C(C)C.Clc1cccnc1Cl.FC(F)(F)c1ccc(Nc2ncnc3c2CNCC3)cn1>>FC(F)(F)c1ccc(Nc2ncnc3c2CN(c2ncccc2Cl)CC3)cn1",
        "output": "220"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCCC1=O.COc1ccc2c3c(sc2c1)-c1ccccc1COC3c1ccc(OCCN2CCCCC2)cc1.ClCCl>>Oc1ccc2c3c(sc2c1)-c1ccccc1COC3c1ccc(OCCN2CCCCC2)cc1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.Cc1ccc(CO)cc1.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.[Na+]>>COc1cc2nccc(Oc3ccc(NC(=O)OCc4ccc(C)cc4)cc3)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1ccc(C(=O)N(C)C)cc1.[Li+].[OH-]>>CN(C)C(=O)c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(N)c1nnc(-c2ccc(Br)cc2)[nH]c1=O.O=C(Cl)C1CCCC1>>CCC(NC(=O)C1CCCC1)c1nnc(-c2ccc(Br)cc2)[nH]c1=O",
        "output": "45"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCC1CCOCC1.CCOC(C)=O.CI.CN(C)C=O.[Cl-].[H-].[NH4+].[Na+]>>CN(CC1CCOCC1)C(=O)OC(C)(C)C",
        "output": "803"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(=O)(=O)c1cccc(B(O)O)c1.O=S(=O)(Oc1ccc(Cl)c(-c2ncnc3c(C(F)(F)F)cccc23)c1)C(F)(F)F>>CS(=O)(=O)c1cccc(-c2ccc(Cl)c(-c3ncnc4c(C(F)(F)F)cccc34)c2)c1",
        "output": "825"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOCC.COC(=O)c1ccc2c(Cl)ccnc2c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1ccc2c(Cl)ccnc2c1",
        "output": "444"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccc(F)cc1Nc1ccc(F)cc1>>Nc1ccc(F)cc1Nc1ccc(F)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1CCC(=O)CC1.CCOC(OCC)OCC.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.OCCO>>CCOC(=O)C1CCC2(CC1)OCCO2",
        "output": "265"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COCCCN1CCOc2ccc(COC3CN(C(=O)OCc4ccccc4)CC(O)C3c3ccc(OC)cc3)cc21.Fc1ccc(Cl)cc1.[H-].[Na+]>>COCCCN1CCOc2ccc(COC3CN(C(=O)OCc4ccccc4)CC(Oc4ccc(Cl)cc4)C3c3ccc(OC)cc3)cc21",
        "output": "485"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)[C@H](NC(=O)N1CCCCCC1)C(=O)O.CCN(C(C)C)C(C)C.CCOCC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1>>CC(C)[C@H](NC(=O)N1CCCCCC1)C(=O)N1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C1COCCO1.CON=C(CCC(=O)O)c1ccc(Cl)c(Cl)c1.N.O=C(n1ccnc1)n1ccnc1>>CON=C(CCC(N)=O)c1ccc(Cl)c(Cl)c1",
        "output": "313"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.C[C@H]1CNCCN1.ClCCl.O=C(Cl)OCc1ccccc1>>C[C@H]1CN(C(=O)OCc2ccccc2)CCN1",
        "output": "427"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.COc1cc2ncnc(Nc3cccc(C(C)=O)c3)c2cc1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>COc1cc2ncnc(Nc3cccc(C(C)=O)c3)c2cc1OS(=O)(=O)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=[N+]([O-])c1ccc(C2CC(O)c3cc(O)ccc3O2)cc1.Oc1ccc2c(c1)CCC(c1cccc(F)c1)O2>>O=[N+]([O-])c1ccc(C2CCc3cc(O)ccc3O2)cc1",
        "output": "447"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CN1c2ccccc2[C@@H]2C[C@@H](NC(=O)C(F)(F)F)CCN2c2ccccc21.O=C(Cl)C(=O)Cl>>CN1c2ccccc2[C@@H]2C[C@@H](NC(=O)C(F)(F)F)CCN2c2ccc(C=O)cc21",
        "output": "239"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCOC(C)=O.COC(=O)c1cccc(-n2cccc2C(=O)OCc2ccccc2)c1.Cl.O.[Na+].[OH-]>>O=C(O)c1cccc(-n2cccc2C(=O)OCc2ccccc2)c1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)N1CCCNCC1.CN(C)C=O.O.O=C([O-])[O-].O=Cc1ccc(F)cc1.[K+].[K+]>>CC(=O)N1CCCN(c2ccc(C=O)cc2)CC1",
        "output": "26"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1csc(-c2ccccc2C(=O)O)n1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1nc2ccc(N)cc2s1)c1ccccc1.F[P-](F)(F)(F)(F)F.O>>CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1nc2ccc(NC(=O)c3ccccc3-c3nc(C(C)(C)C)cs3)cc2s1)c1ccccc1",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.COc1cc(-c2ccnc3c2c(C#N)cn3COCC[Si](C)(C)C)c(Cl)cc1Cl.NCCN.[F-]>>COc1cc(-c2ccnc3[nH]cc(C#N)c23)c(Cl)cc1Cl",
        "output": "897"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COC(=O)[C@H](O)CNC(=O)c1ccc(C(NC(=O)Nc2ccc(SC(F)(F)F)cc2)c2ccc(C3CCCCC3)cc2)cc1.[Na+].[OH-]>>O=C(Nc1ccc(SC(F)(F)F)cc1)NC(c1ccc(C(=O)NC[C@@H](O)C(=O)O)cc1)c1ccc(C2CCCCC2)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@]12CC[C@@H](F)[C@@H]1CN(C(=O)OCc1ccccc1)C2.CO.[C].[H][H].[Pd]>>CC(C)(C)OC(=O)N[C@@]12CC[C@@H](F)[C@@H]1CNC2",
        "output": "428"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.O.O=C(Nc1ccc2ncsc2c1)OCC(Cl)(Cl)Cl.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>O=C(Nc1ccc2ncsc2c1)N1CCN(c2nc(-c3ccccc3)ns2)CC1",
        "output": "980"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)N1C(=O)N(S(=O)(=O)c2ccccc2)CC1c1cccc(Br)c1.CCOc1ccc(F)c(B(O)O)c1.ClCCl.Cl[Pd]Cl.O.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOc1ccc(F)c(-c2cccc(C3CN(S(=O)(=O)c4ccccc4)C(=O)N3C(C)C)c2)c1",
        "output": "908"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "N#Cc1ccc(Oc2cccc(C=O)c2)cc1.N[C@H]1CCCc2ccccc21>>N#Cc1ccc(Oc2cccc(CN[C@H]3CCCc4ccccc43)c2)cc1",
        "output": "683"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)c1ccc(-n2nc(C(C)(C)C)cc2N)cc1.O=C(Cl)Oc1ccccc1>>CC(C)(C)c1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Oc2ccccc2)cc1",
        "output": "700"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1c(C#N)cc(C(=O)O)cc1[N+](=O)[O-].NCc1cccc(Cl)c1>>Cc1c(C#N)cc(C(=O)NCc2cccc(Cl)c2)cc1[N+](=O)[O-]",
        "output": "753"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.OO.c1cnc2c(c1)CCCCC2>>[O-][n+]1cccc2c1CCCCC2",
        "output": "396"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.COCCOC.CS(=O)(=O)c1cccc(B(O)O)c1.O.O=C(NCC(F)(F)F)c1cn(-c2ccc(Br)cc2)c(-c2ccccc2Cl)n1.O=C([O-])[O-].[K+].[K+]>>CS(=O)(=O)c1cccc(-c2ccc(-n3cc(C(=O)NCC(F)(F)F)nc3-c3ccccc3Cl)cc2)c1",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)c1ccnc(-c2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)c1.N#Cc1ccnc(-c2c[nH]cn2)c1>>COC(=O)c1ccnc(-c2c[nH]cn2)c1",
        "output": "838"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOCC.CS(=O)(=O)Cl.Cl.Cl.ClCCl.NCCCNc1cc(C(c2cc(F)ccc2F)S(=O)(=O)c2ccc(Cl)cc2)c(Cl)cn1>>CS(=O)(=O)NCCCNc1cc(C(c2cc(F)ccc2F)S(=O)(=O)c2ccc(Cl)cc2)c(Cl)cn1",
        "output": "493"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CCC1CCCCC1.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.CCOC(C)=O.Cc1ccccc1.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.Nc1ccc(Br)cc1F.[Pd+2]>>Nc1ccc(/C=C/CC2CCCCC2)cc1F",
        "output": "539"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1ccc2nc(-c3ccc4[nH]ccc4c3)c(N3CCOC[C@@H]3C)nc2c1.ClC(Cl)Cl.O.[Na+].[OH-]>>C[C@H]1COCCN1c1nc2cc(C(=O)O)ccc2nc1-c1ccc2[nH]ccc2c1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CSc1ccc(O)cc1F.O.O=C([O-])O.O=S([O-])OO.[K+].[Na+]>>CS(=O)(=O)c1ccc(O)cc1F",
        "output": "730"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.ClCCl.NCc1ccccn1>>CC(C)(C)OC(=O)NCc1ccccn1",
        "output": "631"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.O.O=C1CCc2ccc(Oc3ccc([N+](=O)[O-])cc3Cl)cc21.[Ca+2].[Cl-].[Cl-]>>Nc1ccc(Oc2ccc3c(c2)C(=O)CC3)c(Cl)c1",
        "output": "335"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.COC(=O)[C@@H](N)[C@@H](C)O.Cl.O=C(O)c1ccc(F)c(Br)c1.On1nnc2ccccc21>>COC(=O)[C@@H](NC(=O)c1ccc(F)c(Br)c1)[C@@H](C)O",
        "output": "652"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(=O)C(F)C1.NC1CC1>>CC(C)(C)OC(=O)N1CCC(NC2CC2)C(F)C1",
        "output": "236"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)c1nc2cc(S(=O)(=O)Cl)ccc2n1CC1CCOCC1.O=Cc1cc[nH]c1.[H-].[Na+]>>CC(C)(C)c1nc2cc(S(=O)(=O)n3ccc(C=O)c3)ccc2n1CC1CCOCC1",
        "output": "648"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)CC(=O)Cl.CCO.Nc1ccc(OCc2ccc(F)cc2)cc1N>>CC(C)(C)CC(=O)Nc1ccc(OCc2ccc(F)cc2)cc1N",
        "output": "134"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1ccc2nc(-c3ccccc3)c(N3CCCCC3C)nc2c1.O.[Na+].[OH-]>>CC1CCCCN1c1nc2cc(C(=O)O)ccc2nc1-c1ccccc1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CN(C)C1(CC2CCCCC2)CCC2(CCNC2=O)CC1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CN(C)C1(CC2CCCCC2)CCC2(CCNC2)CC1",
        "output": "112"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc(C2(C#N)CC2)c1.O.O.[Li+].[OH-]>>N#CC1(c2cccc(C(=O)O)c2)CC1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COc1nc(OC[C@@H]2CCCN2C(=O)OC(C)(C)C)ccc1[N+](=O)[O-].[Pd]>>COc1nc(OC[C@@H]2CCCN2C(=O)OC(C)(C)C)ccc1N",
        "output": "269"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCCC(C)O.Cc1ccccc1.N=O.[Na+].[O-]Cl>>CCCCCCC(C)=O",
        "output": "87"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)S(N)(=O)=O.O=C(O)c1ccc(Oc2ccc(Cl)cc2-c2ccnnc2)cc1>>CN(C)S(=O)(=O)NC(=O)c1ccc(Oc2ccc(Cl)cc2-c2ccnnc2)cc1",
        "output": "886"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1nc(-c2cccc(S(=O)(=O)Cl)c2)cs1.Nc1ccccc1S(N)(=O)=O>>Cc1nc(-c2cccc(S(=O)(=O)Nc3ccccc3S(N)(=O)=O)c2)cs1",
        "output": "68"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.OCC1CCOC1>>Cc1ccc(S(=O)(=O)OCC2CCOC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O.CCN(C(C)C)C(C)C.COCCOCCl>>COCCOCOc1c(C(C)(C)C)cc(C=O)cc1C(C)(C)C",
        "output": "375"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(-n2cccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CN)n1.FC(F)(F)c1ccc(Cl)nn1>>Cc1ccc(-n2cccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ccc(C(F)(F)F)nn2)n1",
        "output": "241"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(CCNC(=O)CCCCCCCCCCNC(=O)OCC1c2ccccc2-c2ccccc21)OCC.Cl>>O=CCCNC(=O)CCCCCCCCCCNC(=O)OCC1c2ccccc2-c2ccccc21",
        "output": "409"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cccc(-c2cnc3ccccc3c2)c1.[Al+3].[Cl-].[Cl-].[Cl-]>>Oc1cccc(-c2cnc3ccccc3c2)c1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.COc1nc(C)cnc1N(C(=O)OCC(C)C)S(=O)(=O)c1cccnc1-c1ccc(C)cc1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COc1nc(C)cnc1N(C(=O)OCC(C)C)S(=O)(=O)c1cccnc1-c1ccc(CBr)cc1",
        "output": "29"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.O=[Cr](=O)([O-])Cl.O=[N+]([O-])c1cccc(CO)c1Cl.c1cc[nH+]cc1>>O=Cc1cccc([N+](=O)[O-])c1Cl",
        "output": "179"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCN(C2CCNCC2)C1.Cc1cc(-c2cccc(OC(F)(F)F)c2)nc(C)c1C(=O)O>>Cc1cc(-c2cccc(OC(F)(F)F)c2)nc(C)c1C(=O)N1CCC(N2CCCC2)CC1",
        "output": "256"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CCBr.C=CCCC(C#N)(C#N)Cc1ccc(O)cc1.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>C=CCCC(C#N)(C#N)Cc1ccc(OCC=C)cc1",
        "output": "77"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cccn2c(Cl)c(C[C@@H]3CCCCN3C(=O)OC(C)(C)C)nc12.ClCCl.O=C(O)C(F)(F)F>>Cc1cccn2c(Cl)c(C[C@@H]3CCCCN3)nc12",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)C(=O)Cl.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.O.Oc1ccc(Br)cc1-c1c[nH]cn1>>CC(C)(C)C(=O)Oc1ccc(Br)cc1-c1c[nH]cn1",
        "output": "111"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cl.NC[C@H]1CC[C@@H](CCOc2ccccc2)CC1.O=C(O)c1c[nH]cn1>>O=C(NC[C@H]1CC[C@@H](CCOc2ccccc2)CC1)c1c[nH]cn1",
        "output": "697"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)OCc1c(-c2cc(Nc3ccncn3)c(=O)n(C)c2)ccnc1N1CCn2c(cc3c2CCCC3)C1=O.CC(C)O.O.[Li+].[OH-]>>Cn1cc(-c2ccnc(N3CCn4c(cc5c4CCCC5)C3=O)c2CO)cc(Nc2ccncn2)c1=O",
        "output": "348"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CC(Cc1ccccc1OC)c1ccccc1.CO.[Na+].[OH-]>>COc1ccccc1CC(CC(=O)O)c1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc2c(-c3ccccc3)nccc2c1>>O=S(=O)(Oc1ccc2c(-c3ccccc3)nccc2c1)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cl.N#Cc1ccc2cc[nH]c2c1.NO.O=C([O-])O.[Na+]>>N=C(NO)c1ccc2cc[nH]c2c1",
        "output": "854"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#Cc1ccc(-c2ccc(Cl)cc2)cn1.O=Cc1cc(I)ccc1OCCN1CCCC1>>O=Cc1cc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)ccc1OCCN1CCCC1",
        "output": "664"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.O.O=[N+]([O-])c1ccc(OCc2ccccn2)cc1.[Cl-].[Fe].[NH4+]>>Nc1ccc(OCc2ccccn2)cc1",
        "output": "202"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)O.O=C([O-])O.O=C1CCC(=O)N1Br.O=[N+]([O-])c1ccc(Oc2cccc3c2ccn3CC2CC2)c(Cl)c1.[Na+]>>O=[N+]([O-])c1ccc(Oc2cccc3c2c(Br)cn3CC2CC2)c(Cl)c1",
        "output": "796"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1C1CO1.Oc1ccc(F)cc1>>CC(C)(C)OC(=O)N1CCC[C@H]1C(O)COc1ccc(F)cc1",
        "output": "277"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Br.CC(=O)O.CC(=O)[O-].CCOC(=O)Cc1c(C)n(-c2ncnc3cc(Cl)ccc23)c2ccc(OCc3ccccc3)cc12.O.[Na+]>>CCOC(=O)Cc1c(C)n(-c2ncnc3cc(Cl)ccc23)c2ccc(O)cc12",
        "output": "23"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Nc1ccccc1C(=O)O.O=Cc1ccnc(Br)c1>>O=C(O)c1ccccc1NCc1ccnc(Br)c1",
        "output": "359"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)C(C)Sc1nnnn1-c1cc(C)ccc1C.CO.[Na+].[OH-]>>Cc1ccc(C)c(-n2nnnc2SC(C)C(=O)O)c1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "NOCCO.O=C(O)c1ccc(F)c(F)c1Nc1ccc(C#CCOC2CCCCO2)cc1F.O=C(n1ccnc1)n1ccnc1>>O=C(NOCCO)c1ccc(F)c(F)c1Nc1ccc(C#CCOC2CCCCO2)cc1F",
        "output": "741"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)C=Cc2cc(C#N)ccc2O1.CCO.CO.N.[Ni]>>CC1(C)C=Cc2cc(CN)ccc2O1",
        "output": "175"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)CC(C)c1ccccc1N.CO.II.O=C([O-])O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>CC(C)CC(C)c1cc(I)ccc1N",
        "output": "372"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(CO)COC1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.c1ccncc1>>Cc1ccc(S(=O)(=O)OCC2(C)COC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(C)=O.COC(=O)C(C)Oc1ccccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl.Cl.O>>CC(Oc1ccccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Oc1ccc2nc(N)sc2n1.O=C(Cl)C1CC1.c1ccncc1>>CCc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Oc1ccc2nc(NC(=O)C3CC3)sc2n1",
        "output": "553"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=[N+]=[N-].CC(=O)c1ccc2cc(C(C)C(=O)O)ccc2c1.CCOCC>>COC(=O)C(C)c1ccc2cc(C(C)=O)ccc2c1",
        "output": "60"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.NCC(O)c1cccc2ccccc12>>CC(C)(C)OC(=O)NCC(O)c1cccc2ccccc12",
        "output": "631"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN.CO.FC(F)(F)Oc1ccc(C2CCc3c(Cl)nc(Cl)nc32)cc1>>CNc1nc(Cl)nc2c1CCC2c1ccc(OC(F)(F)F)cc1",
        "output": "110"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "N#CCBr.c1ccc(CN2CCNCC23CC3)cc1>>N#CCN1CCN(Cc2ccccc2)C2(CC2)C1",
        "output": "880"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.CCCCC(O)c1cccc(C)c1.CN(C)c1ccccn1.ClCCl.c1ccncc1>>CCCCC(OC(C)=O)c1cccc(C)c1",
        "output": "254"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(C)=O.FC(F)C(F)(F)Oc1cccc(Nc2nccc(-c3ccnc(Cl)c3)n2)c1.NCCN>>NCCNc1cc(-c2ccnc(Nc3cccc(OC(F)(F)C(F)F)c3)n2)ccn1",
        "output": "70"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.Cc1ccc(-c2ccccc2C=O)cc1.Cl.NO.c1ccncc1>>Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "453"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)c1ccc(C(=O)NC(C(=N)N)C(=O)O)cc1.O=C(CN1CCNCC1)OCc1ccccc1>>CC(C)(C)OC(=O)c1ccc(C(=O)NC(C(=N)N)C(=O)N2CCN(CC(=O)OCc3ccccc3)CC2)cc1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#C[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)O.CC(C)(C)[Si](C)(C)Cl.ClCCl.c1c[nH]cn1>>C#C[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)O[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)Cn1c(C)cc2c([N+](=O)[O-])cccc21.Cl.[Na+].[OH-]>>Cc1cc2c([N+](=O)[O-])cccc2n1CC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CCCCO.CCOCC.N#Cc1ccccc1F.[N-]=[N+]=[N-].[Na+]>>Fc1ccccc1-c1nnn[nH]1",
        "output": "390"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(CCI)cn1.COc1cc(OC)c(Cl)c(-c2cc3cnc(SC)nc3[nH]c2=O)c1>>COc1cc(OC)c(Cl)c(-c2cc3cnc(SC)nc3n(CCc3ccc(NC(=O)OC(C)(C)C)nc3)c2=O)c1",
        "output": "326"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCCn1c2c(c3cc(F)ccc31)CN(C(=O)OCC)CC2.CCO.[K+].[OH-]>>CCCCCCCCn1c2c(c3cc(F)ccc31)CNCC2",
        "output": "283"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.C[Si](C)(C)C#Cc1cccc(-c2ccccc2)c1.ClCCl.O=C([O-])[O-].[Cs+].[Cs+]>>C#Cc1cccc(-c2ccccc2)c1",
        "output": "337"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Clc1ccc(N2CCNCC2)cc1.N#CCCCBr.O.O=C([O-])[O-].[K+].[K+]>>N#CCCCN1CCN(c2ccc(Cl)cc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCNC1.O=C(O)c1ccc(-c2nc3c(s2)CCN(C2CCC2)CC3)cn1>>O=C(c1ccc(-c2nc3c(s2)CCN(C2CCC2)CC3)cn1)N1CCCC1",
        "output": "605"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.N#Cc1cc([N+](=O)[O-])ccc1OCCCN1CCOCC1.O.[Cl-].[Fe].[NH4+]>>N#Cc1cc(N)ccc1OCCCN1CCOCC1",
        "output": "202"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrBr.CC(=O)c1ccc(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c1.CC(C)(C)C(=O)Cl.CCC(=O)c1ccc(O)c(O)c1.CCC(=O)c1ccc(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c1.CCN(CC)CC>>CC(C)(C)C(=O)Oc1ccc(C(=O)CBr)cc1OC(=O)C(C)(C)C",
        "output": "173"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.CCOC(C)=O.Cl.Nc1ccccc1.O.O=C(c1ncc[nH]1)c1ncc[nH]1>>CC(C)(C)OC(=O)N1CCC(C(=O)Nc2ccccc2)CC1",
        "output": "365"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccccc1.O=C(O)CCNc1cccc(Cl)c1[N+](=O)[O-].O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3>>O=C1CCNc2c1ccc(Cl)c2[N+](=O)[O-]",
        "output": "274"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)CO.N#Cc1cnc2ccc(I)cc2c1Cl.[H-].[K+]>>CC(C)COc1c(C#N)cnc2ccc(I)cc12",
        "output": "651"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.ClCCl.O=C([O-])O.O=C1NC(=O)C(Cc2ccc(OCC(O)c3cccc(Cl)c3)cc2)S1.O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3.[Na+]>>O=C1NC(=O)C(Cc2ccc(OCC(=O)c3cccc(Cl)c3)cc2)S1",
        "output": "32"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)C1CCN(c2cc(C(N)=O)cc(-c3ccnc(NC4CCCCC4)c3)n2)CC1.CC[SiH](CC)CC.ClCCl.O=C(O)C(F)(F)F>>NC(=O)c1cc(-c2ccnc(NC3CCCCC3)c2)nc(N2CCC(C(=O)O)CC2)c1",
        "output": "278"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCCC.CCCCP(CCCC)CCCC.Cc1cc(O)cc(OS(=O)(=O)c2cccc3cnccc23)c1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.OCCCO>>Cc1cc(OCCCO)cc(OS(=O)(=O)c2cccc3cnccc23)c1",
        "output": "478"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.O=c1c2c([N+](=O)[O-])cccc2cnn1-c1cccc(C(F)(F)F)c1.[H][H].[Pd]>>Nc1cccc2cnn(-c3cccc(C(F)(F)F)c3)c(=O)c12",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(CO)N1CCNCC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)Cc1nc2c(N3CCOCC3)nc(Cl)nc2s1>>CC(C)(CO)N1CCN(C(=O)Cc2nc3c(N4CCOCC4)nc(Cl)nc3s2)CC1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1cc(Cl)nnc1Cl.CCO.Cl.NN.O>>CC(C)(C)c1cc(NN)nnc1Cl",
        "output": "284"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)CC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.CN(C)C=O.Fc1ccc(CBr)c(Cl)c1.O.[H-].[I-].[Na+]>>CC(C)(C)OC(=O)N1CCC(OCc2ccc(F)cc2Cl)CC1",
        "output": "464"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1CCC2(CCNCC2)C1.CC(C)(C)[O-].Cc1ccccc1.FC(F)(F)c1cnc(Cl)nc1.[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)OC(=O)N1CCC2(CCN(c3ncc(C(F)(F)F)cn3)CC2)C1",
        "output": "36"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Cl.Cl.FC(F)(F)C1CO1.O=C([O-])[O-].[Cs+].[Cs+].c1cc(OC2CCCNC2)ccn1>>OC(CN1CCCC(Oc2ccncc2)C1)C(F)(F)F",
        "output": "76"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrB(Br)Br.CCCC1CC(=O)N(Cn2c(Cl)nc3ccc(OC)cc32)C1.ClCCl.O=C([O-])O.[Na+]>>CCCC1CC(=O)N(Cn2c(Cl)nc3ccc(O)cc32)C1",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)n1nc(N)nc1-c1cn2c(n1)-c1cc(Br)ccc1OCC2.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccccc1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)n1nc(N)nc1-c1cn2c(n1)-c1cc(-c3ccccc3)ccc1OCC2",
        "output": "837"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cc1ccc2c(OCCBr)cccc2n1.Cl.O=C([O-])[O-].O=[N+]([O-])c1cccc(C=C2CCNCC2)c1.[K+].[K+]>>Cc1ccc2c(OCCN3CCC(=Cc4cccc([N+](=O)[O-])c4)CC3)cccc2n1",
        "output": "73"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.CCOC(C)=O.COc1nccc2c(Nc3c(Cl)cc(C#N)cc3Cl)nc3ccncc3c12.ClC(Cl)Cl>>N#Cc1cc(Cl)c(Nc2nc3ccncc3c3c(=O)[nH]ccc23)c(Cl)c1",
        "output": "758"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.Cl.Fc1ccc(F)c(Br)c1.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)c1cc(F)c(Br)cc1F",
        "output": "31"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#CC[C@H](C[C@H](O)[C@@H](N)Cc1ccccc1)C(=O)NC1CC2CCC1C2.C[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc(N2CCCC2=O)cc(N2CCCC2=O)c1)C(=O)NCCC(C)(C)C.O=C(O)c1cc(N2CCCC2=O)cc(N2CCCC2=O)c1>>C#CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc(N2CCCC2=O)cc(N2CCCC2=O)c1)C(=O)NC1CC2CCC1C2",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Nc1ccccc1.O=Cc1ccc2cccnc2c1[N+](=O)[O-].[BH4-].[Na+]>>O=[N+]([O-])c1c(CNc2ccccc2)ccc2cccnc12",
        "output": "359"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.Nc1cccc(F)c1>>CC(C)(C)CC1NC(C(=O)Nc2cccc(F)c2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F",
        "output": "563"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.CCOC(=O)c1ccc(OCC2CCN(C(=O)OC(C)(C)C)CC2)c(OC)c1.CCOCC.Cl.O.O=CO>>CCOC(=O)c1ccc(OCC2CCN(C)CC2)c(OC)c1",
        "output": "881"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(OCCN)nc2s1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(OCCNC(=O)C(F)(F)F)nc2s1",
        "output": "316"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)Cl.ClCCl.O=C([O-])[O-].O=[N+]([O-])c1cccc2c3c([nH]c12)CCNC3.[K+].[K+]>>CCOC(=O)N1CCc2[nH]c3c([N+](=O)[O-])cccc3c2C1",
        "output": "219"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCn2ccc(C#N)c2C1.CO.O.O=S([O-])([O-])=S.OO.[Na+].[Na+].[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCn2ccc(C(N)=O)c2C1",
        "output": "677"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(SC(F)(F)F)C(=O)C(Oc1ccc(Cl)cc1)n1cncn1.CO.O.[BH4-].[Na+]>>CC(C)(SC(F)(F)F)C(O)C(Oc1ccc(Cl)cc1)n1cncn1",
        "output": "91"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCBr.CN(C)C=O.Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1.[H-].[Na+]>>CCCO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1ccc(N)nc1=O",
        "output": "95"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN1CCCC1=O.Cc1noc(C)c1-c1cc(I)c2nc(Cl)[nH]c2c1.NCc1ccccc1>>Cc1noc(C)c1-c1cc(I)c2nc(NCc3ccccc3)[nH]c2c1",
        "output": "364"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(NC(c2cnc(-c3ccc(C(F)(F)F)cc3)nc2)C2CCCCC2)nc1.[Li+].[OH-]>>O=C(O)c1ccc(NC(c2cnc(-c3ccc(C(F)(F)F)cc3)nc2)C2CCCCC2)nc1",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CC(=O)Cl.Cl.ClCCl.O=C(O)c1ccc(N2CCNCC2)nc1-c1ccc(Oc2ccccc2)cc1>>C=CC(=O)N1CCN(c2ccc(C(=O)O)c(-c3ccc(Oc4ccccc4)cc3)n2)CC1",
        "output": "135"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1=CN2CCCNC2CCC1.CC#N.CC(C)(C)OC(=O)Nc1ccc(CCCOS(C)(=O)=O)cc1.CCN(CC)CC.Cl.Cl.O=C(NC1CCNCC1)C1=Cc2cnc3cccc(n23)S1.[I-].[Na+]>>CC(C)(C)OC(=O)Nc1ccc(CCCN2CCC(NC(=O)C3=Cc4cnc5cccc(n45)S3)CC2)cc1",
        "output": "496"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CN(C)[SH](=O)=O.O.O=Cc1cccc(O)c1O.[H-].[H][H].[Na+]>>O=Cc1cccc(OCc2ccccc2)c1O",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCCC1=O.Cc1c(C(=O)N(C)C)cc(C(=O)O)c(=O)n1-c1cccc(C(F)(F)F)c1.F[P-](F)(F)(F)(F)F.NCC1CCCCC1.On1nnc2cccnc21>>Cc1c(C(=O)N(C)C)cc(C(=O)NCC2CCCCC2)c(=O)n1-c1cccc(C(F)(F)F)c1",
        "output": "674"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Clc1ccc(OCCBr)cc1.O=C1C(=O)c2ccccc2C2=C1SCC1(CCNCC1)O2>>O=C1C(=O)c2ccccc2C2=C1SCC1(CCN(CCOc3ccc(Cl)cc3)CC1)O2",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CNCc1ccccc1N1CCOCC1.O=C(O)CCCCc1ccc(O)cc1>>CN(Cc1ccccc1N1CCOCC1)C(=O)CCCCc1ccc(O)cc1",
        "output": "633"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.NOC(c1ccccc1)(c1ccccc1)c1ccccc1.O=Cc1ccccc1>>C(=NOC(c1ccccc1)(c1ccccc1)c1ccccc1)c1ccccc1",
        "output": "30"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.NC(=O)c1cc(-c2ccsc2)cc2c(C3CCN(S(=O)(=O)CCCCl)CC3)c[nH]c12.NS(N)(=O)=O.O=C([O-])[O-].[K+].[K+]>>NC(=O)c1cc(-c2ccsc2)cc2c(C3CCN(S(=O)(=O)CCCN4CCOCC4)CC3)c[nH]c12",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)c1ccc(N2CCN(c3ccncc3)CC2)cc1.[Na+].[OH-]>>O=C(O)c1ccc(N2CCN(c3ccncc3)CC2)cc1",
        "output": "5"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cc1ccc(S(=O)(=O)n2c(-c3ccc(C(=O)O)cc3)cc3c(-c4cnc(C5(O)CCC5)s4)c(Cl)cnc32)cc1.[Na+].[OH-]>>O=C(O)c1ccc(-c2cc3c(-c4cnc(C5(O)CCC5)s4)c(Cl)cnc3[nH]2)cc1",
        "output": "949"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1cncc(Br)c1.C1COCCO1.CC(C)(C)OC(=O)N1CCNCC1.CC(C)(C)[O-].O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CC(C)(C)OC(=O)N1CCN(c2cncc(Br)c2)CC1",
        "output": "597"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCN(C(C)C)C(C)C.ClCCCCn1nnc2ccccc21.FC(F)(F)c1cccc(C2CCNCC2)c1.[I-].[K+]>>FC(F)(F)c1cccc(C2CCN(CCCCn3nnc4ccccc43)CC2)c1",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)[C@@H]1CC[C@@H](N)CC1.CS(=O)(=O)c1nccc(-n2ncc3ccccc32)n1>>CCOC(=O)[C@@H]1CC[C@@H](Nc2nccc(-n3ncc4ccccc43)n2)CC1",
        "output": "629"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1nc2cccc(C)n2c1-c1cccc(C(F)(F)F)c1.CO.O.[K+].[OH-]>>Cc1cccc2nc(C(=O)O)c(-c3cccc(C(F)(F)F)c3)n12",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)[N-]C(C)C.CN(C)C=O.Cc1cc(F)ccc1Br.Cl.O.[Li+]>>Cc1cc(F)c(C=O)cc1Br",
        "output": "239"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(Cl)c(N)c1.CC(C)=O.CC(C)Nc1cc(NC(=O)OC(C)(C)C)ccc1Cl.CO.[BH3-]C#N.[Cl-].[Cl-].[Na+].[Zn+2]>>CC(C)Nc1cc(N)ccc1Cl",
        "output": "782"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.ClCCl.NC(=O)c1[nH]c2ccc(C=O)cc2c1Sc1ccccc1.Nc1ccccc1F>>NC(=O)c1[nH]c2ccc(CNc3ccccc3F)cc2c1Sc1ccccc1",
        "output": "359"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN.O=C(O)Cc1ccc(O)c(F)c1>>CNC(=O)Cc1ccc(O)c(F)c1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.CN1CCOCC1.COC(=O)c1cccc2nc(-c3c(Cl)cc[nH]c3=O)[nH]c12.NC[C@@H](O)c1ccccc1.O>>COC(=O)c1cccc2nc(-c3c(NC[C@@H](O)c4ccccc4)cc[nH]c3=O)[nH]c12",
        "output": "78"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)CCCO.COc1cc2c(Cl)ncnc2cc1O>>COc1cc2c(Cl)ncnc2cc1OCCCN(C)C",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COCCS(N)(=O)=O.NS(=O)(=O)N1CCC1.O=C(O)c1cc(C2CC2)c(OCC2CCCC2)cc1F.O=C(O)c1cc(I)c(OCC23CC4CC(CC(C4)C2)C3)cc1F>>COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCC2)cc1F",
        "output": "580"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.C1=CCCCC1.COc1ccc(-c2nn(CC(C)C)c3c(F)cccc23)c(C)c1>>Cc1cc(O)ccc1-c1nn(CC(C)C)c2c(F)cccc12",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)C=O.Cl.NCc1ccccc1Br.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)OC(=O)NCc1ccccc1Br",
        "output": "686"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)c1c(NC(=O)c2cc3c(F)cccn3n2)csc1-c1ccc(C)c(F)c1F.O.[Li+].[OH-]>>Cc1ccc(-c2scc(NC(=O)c3cc4c(F)cccn4n3)c2C(=O)O)c(F)c1F",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)c1ccc(OCc2ccccn2)cc1.[Na+].[OH-]>>O=C(O)c1ccc(OCc2ccccn2)cc1",
        "output": "386"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc(N)ccc1-n1cnc(C)c1.Cc1cc(Cl)nc(N2CCCC2)n1>>COc1cc(Nc2cc(C)nc(N3CCCC3)n2)ccc1-n1cnc(C)c1",
        "output": "161"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.O=C1N[C@@]2(CC[C@H](c3ccc4c(c3)CC[C@@H](CO)C4)C2)CO1.c1ccncc1>>Cc1ccc(S(=O)(=O)OC[C@@H]2CCc3cc([C@H]4CC[C@]5(COC(=O)N5)C4)ccc3C2)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cl.Cl[Sn]Cl.N#Cc1ccc(Nc2ccncc2[N+](=O)[O-])cc1.O.O.O>>N#Cc1ccc(Nc2ccncc2N)cc1",
        "output": "269"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C[O-].Cl.ClCCl.Nc1cc(F)c(F)c(F)c1.O=C([O-])[O-].[Na+].[Na+].[Na+]>>COc1cc(N)cc(F)c1F",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.COC(=O)C1CN(C(=O)OC(C)(C)C)CCN1C(=O)OCc1ccccc1.[BH4-].[Cl-].[Li+].[Na+]>>CC(C)(C)OC(=O)N1CCN(C(=O)OCc2ccccc2)C(CO)C1",
        "output": "430"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)Cl.Cc1cnc(N)cn1>>CC(=O)Nc1cnc(C)cn1",
        "output": "399"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.NCCN1CCOCC1.[Cl-].[Cl-].[Cl-].[In+3]>>CC(C)(C)OC(=O)NCCN1CCOCC1",
        "output": "631"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.ClCC1=C(c2ccccc2)CCCC1.O=C([O-])[O-].O=Cc1c(O)cccc1O.[K+].[K+]>>O=Cc1c(O)cccc1OCC1=C(c2ccccc2)CCCC1",
        "output": "119"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1ccc(-c2ccc(OC3CN(Cc4ccc(C(C)C)cc4)C3)cn2)cc1.NCCO>>CC(C)c1ccc(CN2CC(Oc3ccc(-c4ccc(C(=O)NCCO)cc4)nc3)C2)cc1",
        "output": "338"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1CCc2cc(F)cc3c(=O)c(C(=O)O)cn1c23.O=S(Cl)Cl>>CC1CCc2cc(F)cc3c(=O)c(C(=O)Cl)cn1c23",
        "output": "188"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.O=[N+]([O-])c1cccc(OCCCCl)c1.[H][H].[Ni].[Pd]>>Nc1cccc(OCCCCl)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(S(=O)(=O)N(CCCl)CCCl)cc1.NC(=O)c1cc2cc(N)ccc2o1>>Cc1ccc(S(=O)(=O)N2CCN(c3ccc4oc(C(N)=O)cc4c3)CC2)cc1",
        "output": "640"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1cc(CCC(=O)O)cc(C(C)(C)C)c1O.CCCCCCCCCCCCCCCCCC(=O)NCCO.CCCC[O-].CCCC[O-].CCCC[O-].CCCC[O-].Cc1ccccc1C.O.[Ti+4]>>CCCCCCCCCCCCCCCCCC(=O)NCCOC(=O)CCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COc1ccc(C(=O)CBr)cc1.[BH4-].[Na+]>>COc1ccc(C(O)CBr)cc1",
        "output": "24"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "N#CCCNN.O=Cc1ccc(O)cc1O>>N#CCCNN=Cc1ccc(O)cc1O",
        "output": "167"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1CN(c2cc3c(cc2F)C(=O)C(=O)N3)CCN1>>CC1CN(c2cc3c(cc2F)C(=O)C(=O)N3)CCN1C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(OC(F)(F)F)cc1C(=O)c1ccccc1.Cl.ClCCl.c1ccncc1>>O=C(c1ccccc1)c1cc(OC(F)(F)F)ccc1O",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1sc(Br)nc1-c1ccc(OC)cc1.O.O.[Li+].[OH-]>>COc1ccc(-c2nc(Br)sc2C(=O)O)cc1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1sc2c(OC)ccc(F)c2c1Cl.O.[Li+].[OH-]>>COc1ccc(F)c2c(Cl)c(C(=O)O)sc12",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "B.C1CCOC1.CSC.O.O=C(O)CCCCCCCCCCS>>OCCCCCCCCCCCS",
        "output": "231"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)OCC#N.Cc1ccc([C@@H](N)c2ccccc2)c(C)c1.Cc1noc(C)c1C(CO)c1cc2cc(CC(=O)O)ccc2o1>>Cc1ccc([C@@H](NC(=O)Cc2ccc3oc(C(CO)c4c(C)noc4C)cc3c2)c2ccccc2)c(C)c1",
        "output": "769"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1cccc(N2CC3CCC(C2)O3)c1.C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2cccc(N3CC4CCC(C3)O4)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.ClCCl.NCc1ccc(C(=O)N2N=C(c3cccnc3)CC2c2ccccc2O)s1.O.O=C(O)c1ccccn1>>O=C(NCc1ccc(C(=O)N2N=C(c3cccnc3)CC2c2ccccc2O)s1)c1ccccn1",
        "output": "137"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)[SiH](C(C)C)C(C)C.COc1cc(C#N)cc(-c2nc(-c3ccc4c(c3)cc3n4CCC3CC(=O)OC(C)(C)C)no2)c1.ClCCl.O=C(O)C(F)(F)F>>COc1cc(C#N)cc(-c2nc(-c3ccc4c(c3)cc3n4CCC3CC(=O)O)no2)c1",
        "output": "278"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCBr.CN(C)C=O.COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccc2C(=O)O)CC1.Cl.O.O.O=C([O-])[O-].[K+].[K+]>>CCCOC(=O)c1ccccc1N(CCN1CCN(c2ccccc2OC)CC1)C(=O)C1CCCCC1",
        "output": "416"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(O)COc1cccc(Br)c1.O=S(Cl)Cl>>O=C(Cl)COc1cccc(Br)c1",
        "output": "53"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCc1ccc(Nc2c(C(=O)O)ccc(F)c2F)c(F)c1.NOCCO.O=C(n1ccnc1)n1ccnc1>>CCCCc1ccc(Nc2c(C(=O)NOCCO)ccc(F)c2F)c(F)c1",
        "output": "741"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.Clc1ccc2c(Cl)nncc2c1.O=C1OC[C@H]2CNCCN12>>O=C1OC[C@H]2CN(c3nncc4cc(Cl)ccc34)CCN12",
        "output": "406"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cccc(B(O)O)c1.NC(=O)c1ccc2cncc(Br)c2n1>>COc1cccc(-c2cncc3ccc(C(N)=O)nc23)c1",
        "output": "871"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CSc1nccc(-c2nc(=O)c3ccccc3s2)n1.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nccc(-c2nc(=O)c3ccccc3s2)n1",
        "output": "595"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Nc1cccc2cc(OCc3ccccc3)ccc12.CCO.O.[K+].[OH-]>>Nc1cccc2cc(OCc3ccccc3)ccc12",
        "output": "66"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCN.CCOCC.CO.O=Cc1ccc(Br)cc1.[H][H].[Pt]>>CCCNCc1ccc(Br)cc1",
        "output": "468"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1NCCc2cc(-c3cn[nH]c3)ccc21.O=C(O)c1cc2ncc(Br)cn2n1>>CC1c2ccc(-c3cn[nH]c3)cc2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "952"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CO.O=C(O)Cc1ccc2cccnc2c1.O=S(Cl)Cl>>COC(=O)Cc1ccc2cccnc2c1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.O=C(O)C=Cc1cc(F)c(Br)cc1F.[Cl-].[Rh].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(O)CCc1cc(F)c(Br)cc1F",
        "output": "344"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.N#Cc1cccc(Cl)c1[N+](=O)[O-].NC[C@@H]1CCN(C(=O)C2CC2)C1>>N#Cc1cccc(NC[C@@H]2CCN(C(=O)C3CC3)C2)c1[N+](=O)[O-]",
        "output": "304"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)c1ccncc1.NC(=O)c1cc(-c2ccccc2)cc2c1cnn2C1CCNCC1.O=S(=O)(Cl)c1ccc(F)cc1>>NC(=O)c1cc(-c2ccccc2)cc2c1cnn2C1CCN(S(=O)(=O)c2ccc(F)cc2)CC1",
        "output": "99"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCN(CC)CC.CCOC(=O)Cc1ccc(N)c(Cl)c1F.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cc(OCc2cccc(Cl)c2)ccc1Cl>>CCOC(=O)Cc1ccc(NC(=O)c2cc(OCc3cccc(Cl)c3)ccc2Cl)c(Cl)c1F",
        "output": "50"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CN(C)C=O.FCOc1ccc(Cl)cc1F.[Li]CCCC>>O=Cc1c(Cl)ccc(OCF)c1F",
        "output": "239"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.Fc1ccc(CC2CCNCC2)cc1.O=C(NC(Cc1ccccc1)C1CO1)OCc1ccccc1>>O=C(NC(Cc1ccccc1)C(O)CN1CCC(Cc2ccc(F)cc2)CC1)OCc1ccccc1",
        "output": "76"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1sc(N)nc1-c1ccccc1.Cc1c(Cl)cccc1S(=O)(=O)Cl>>CCOC(=O)c1sc(NS(=O)(=O)c2cccc(Cl)c2C)nc1-c1ccccc1",
        "output": "637"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1cc(-c2c(OC)cc(OC)cc2OC)cc(C(=O)OCC)n1.Cl.[BH4-].[Na+]>>CCOC(=O)c1cc(-c2c(OC)cc(OC)cc2OC)cc(CO)n1",
        "output": "711"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CCO.CCc1nc(C)cc(=O)n1CCOc1ccc(C=O)cc1.Cl.NO.O.O.O.O.[Na+]>>CCc1nc(C)cc(=O)n1CCOc1ccc(C=NO)cc1",
        "output": "30"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCI.COc1ccc(-c2n[nH]c3c(C(F)(F)F)cccc23)c(C)c1.[H-].[Na+]>>CCCn1nc(-c2ccc(OC)cc2C)c2cccc(C(F)(F)F)c21",
        "output": "346"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C[Mg]Br.Cl.N#Cc1ccccc1-c1ccc(C=O)cc1>>CC(O)c1ccc(-c2ccccc2C#N)cc1",
        "output": "787"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2[nH]c1=O.NCc1cccnc1>>O=C(NCc1cccnc1)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2[nH]c1=O",
        "output": "498"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(CC2CN(Cc3ccccc3)C(=O)N2C(C(=O)OC(C)(C)C)C(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(CC2CN(Cc3ccccc3)C(=O)N2C(C(=O)O)C(C)C)cc1",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)O.CC=C(C)C.Cc1ccc(C(F)(F)F)c(O)c1C=O.Cl.O.O=P([O-])(O)O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+].[Na+].[O-][Cl+][O-]>>Cc1ccc(C(F)(F)F)c(O)c1C(=O)O",
        "output": "384"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.CC(=O)[O-].CC(=O)[O-].CCOC(C)=O.Cc1cc(Br)ccc1-c1nc2nc(C#N)nc(N[C@H](C)C3CCC3)c2n1Cc1ccc(C(F)(F)F)cc1.Cc1ccccc1.O.O=P([O-])([O-])[O-].OB(O)C1CC1.[K+].[K+].[K+].[Pd+2]>>Cc1cc(C2CC2)ccc1-c1nc2nc(C#N)nc(N[C@H](C)C3CCC3)c2n1Cc1ccc(C(F)(F)F)cc1",
        "output": "956"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CC1(c2ccc(O)cc2)COC1.CCOC(=O)CC1(c2ccc(OCc3cccc(-c4ccc(C(F)(F)F)cc4)c3)cc2)COC1.Fc1cc(CBr)ccc1OC(F)(F)F>>CCOC(=O)CC1(c2ccc(OCc3ccc(OC(F)(F)F)c(F)c3)cc2)COC1",
        "output": "127"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(C(=O)O)ccc1[N+](=O)[O-].Cc1ccccc1.O=S(Cl)Cl>>COc1cc(C(=O)Cl)ccc1[N+](=O)[O-]",
        "output": "3"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(Cl)cnc1N.O=S(=O)(Cl)c1ccc(F)cc1.c1ccncc1>>Cc1cc(Cl)cnc1NS(=O)(=O)c1ccc(F)cc1",
        "output": "462"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CCBr.CC(C)=O.COc1ccc(C=O)c(O)c1.O=C([O-])[O-].[K+].[K+]>>C=CCOc1cc(OC)ccc1C=O",
        "output": "77"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=C(C)C(=O)Cl.CCCC1CCC(C2CCC(CCCO)CC2)CC1.CCN(CC)CC.ClCCl>>C=C(C)C(=O)OCCCC1CCC(C2CCC(CCC)CC2)CC1",
        "output": "320"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O.O.O=C(O)C(F)(F)c1ccc(F)c(F)c1>>O=C1CCC(N2Cc3cc(CNC(=O)C(F)(F)c4ccc(F)c(F)c4)ccc3C2=O)C(=O)N1",
        "output": "599"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.Cc1cccc(C(=O)Nc2ccc(N3CCNCC3)nc2)c1-c1ccc(C(C)C)cc1.NC(=O)CBr>>Cc1cccc(C(=O)Nc2ccc(N3CCN(CC(N)=O)CC3)nc2)c1-c1ccc(C(C)C)cc1",
        "output": "443"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CSc1csc(S(N)(=O)=O)c1.ClC(Cl)Cl.O=C1CCC(=O)N1Br.[Na+].[OH-]>>CSc1cc(S(N)(=O)=O)sc1Br",
        "output": "807"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cc(-c2cc(F)cc(C(F)(F)F)c2)n(-c2cccc(Cl)c2)n1.O=C(O)c1cc(-c2cc(F)cc(Cl)c2)n(-c2ccc(F)c(Cl)c2)n1>>O=C(O)c1cc(-c2cc(F)cc(C(F)(F)F)c2)n(-c2cccc(Cl)c2)n1",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCCCCBr.CN(C)C=O.O.O=C([O-])[O-].Oc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl.[K+].[K+]>>ClC(Cl)=CCOc1cc(Cl)c(OCCCCBr)c(Cl)c1",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)c2cc(F)ccc2C(F)(F)F)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(c1cc(F)ccc1C(F)(F)F)N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1ccc(I)cc1.CC1(C)OB(c2ccc3c(c2)c2ccccc2n3-c2ccccc2)OC1(C)C.Cc1ccccc1.O=C([O-])[O-].[Na+].[Na+]>>Ic1ccc(-c2ccc3c(c2)c2ccccc2n3-c2ccccc2)cc1",
        "output": "933"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.COCCOc1cc(OC)ccc1-c1ncnc2c(C(=O)NC3CCNCC3)c[nH]c12>>COCCOc1cc(OC)ccc1-c1ncnc2c(C(=O)NC3CCN(C(C)=O)CC3)c[nH]c12",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)[C@@H]1C[C@@H](C#N)CN1C(=O)OC(C)(C)C.[Ni]>>COC(=O)[C@@H]1C[C@@H](CN)CN1C(=O)OC(C)(C)C",
        "output": "246"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCO.COCOc1ccc(C2CCCC(=O)C2)c(OCOC)c1.Cl.NO>>COCOc1ccc(C2CCCC(=NO)C2)c(OCOC)c1",
        "output": "86"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCCN.CCO.CCOC(=O)COc1ccc(C=O)cc1C.[Na+]>>CCCCNCc1ccc(OCC(=O)OCC)c(C)c1",
        "output": "468"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1ccnc(C2COC2)c1.O.[Li+].[OH-]>>O=C(O)c1ccnc(C2COC2)c1",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(OCCCN2CCOCC2)ccc1[N+](=O)[O-].[Pd]>>Cc1cc(OCCCN2CCOCC2)ccc1N",
        "output": "202"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCCBr.CC(C)=O.O=C([O-])[O-].Oc1ccc(Br)cc1.[K+].[K+]>>BrCCOc1ccc(Br)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cccc(-c2csc(Cl)n2)c1.ClC(Cl)(Cl)Cl.ClCCCl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>Clc1nc(-c2cccc(CBr)c2)cs1",
        "output": "29"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CC(CO)(CO)C(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cl.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCN(C(=O)C(C)(CO)CO)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NCCc1cccc(C(F)(F)F)c1.O=C(NCCc1ccc(Cl)c(Cl)c1)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1.O=C(O)c1ccc(C(F)(F)F)c(Cl)c1>>O=C(NCCc1cccc(C(F)(F)F)c1)c1ccc(C(F)(F)F)c(Cl)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@@H]1CN.CCN(C(C)C)C(C)C.ClCCl.O=C(Cl)CCl>>CC(C)(C)OC(=O)N1CCC[C@@H]1CNC(=O)CCl",
        "output": "45"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.ClCCCN1CCCC1.Oc1ccc2ncnc(Nc3ccc(F)c(Cl)c3)c2c1>>Fc1ccc(Nc2ncnc3ccc(OCCCN4CCCC4)cc23)cc1Cl",
        "output": "74"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC1CCN(c2nc(C(F)(F)F)ccc2CN)CC1.CCN(CC)CC.COCCOc1ccc(NC(=O)Oc2ccccc2)cn1>>COCCOc1ccc(NC(=O)NCc2ccc(C(F)(F)F)nc2N2CCC(C)CC2)cn1",
        "output": "488"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)Nc1ccc([N+](=O)[O-])cn1.[Zn]>>CC(C)(C)OC(=O)Nc1ccc(N)cn1",
        "output": "269"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.COc1cccc(-c2nc(C(F)(F)F)cs2)c1>>Oc1cccc(-c2nc(C(F)(F)F)cs2)c1",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=O.Nc1ccc(O)cc1.O=C(Cl)CCCBr>>O=C(CCCBr)Nc1ccc(O)cc1",
        "output": "9"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.COS(=O)(=O)OC.O=C([O-])[O-].O=Cc1ccc2c(Br)c(O)ccc2c1.[K+].[K+]>>COc1ccc2cc(C=O)ccc2c1Br",
        "output": "317"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCOC(=O)C(Cc1ccccc1)c1[nH]c2ccc(O)cc2c1SC(C)(C)C.Cl.ClCc1ccccn1.O.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)C(Cc1ccccc1)c1[nH]c2ccc(OCc3ccccn3)cc2c1SC(C)(C)C",
        "output": "616"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(N2CC3(CCCCCC3)N(C3CC3)C2=O)cc1.CCOC(C)=O.CO.[Li+].[OH-]>>O=C(O)c1ccc(N2CC3(CCCCCC3)N(C3CC3)C2=O)cc1",
        "output": "5"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(Br)cc(C(=O)O)c1C.F[P-](F)(F)(F)(F)F.NC1CC1>>Cc1cc(Br)cc(C(=O)NC2CC2)c1C",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[O-].CCOC(=O)CCCCBr.CN(C)C=O.COc1cc(O)cc(OC)c1C=O.[K+]>>CCOC(=O)CCCCOc1cc(OC)c(C=O)c(OC)c1",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCCC1c1ccc(-c2nc3c(C(N)=O)cc(F)cc3[nH]2)c(F)c1.ClCCl.O=C(O)C(F)(F)F>>NC(=O)c1cc(F)cc2[nH]c(-c3ccc(C4CCCN4)cc3F)nc12",
        "output": "887"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N(C)C.Nc1cn2cc(Oc3ccc(NC(=O)OCc4ccccc4)c(F)c3)ccc2n1.O.O=C(Cl)C1CC1.O=C([O-])O.[Na+]>>O=C(Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)cc1F)OCc1ccccc1",
        "output": "399"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc(C=O)cc(C)c1O.Cc1ccccc1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>Cc1cc(C=O)cc(C)c1OS(=O)(=O)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)c1cc(C(C)C)c(S(=O)(=O)Cl)c(C(C)C)c1.N#CC=CS(=O)(=O)c1ccc(N)cc1.c1ccncc1>>CC(C)c1cc(C(C)C)c(S(=O)(=O)Nc2ccc(S(=O)(=O)C=CC#N)cc2)c(C(C)C)c1",
        "output": "68"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)O.COCCOc1ccc(OCC2CO2)cc1.NCCNC(=O)N1CCOCC1.O=C([O-])[O-].O=S(=O)([O-])[O-].[K+].[K+]>>COCCOc1ccc(OCC(O)CNCCNC(=O)N2CCOCC2)cc1",
        "output": "16"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1nc(Cl)c(SC)c(OC)n1.O.[K+].[OH-]>>COc1nc(OC)c(SC)c(OC)n1",
        "output": "461"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NCC(=O)N1CCC[C@H]1C(=O)OCc1ccccc1.CC(C)(C)OC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)O)c1ccccc1>>CC(C)(C)OC(=O)NCC(=O)N1CCC[C@H]1C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)NCC(=O)O.COc1ccc(-c2ccc(C#N)cc2)cc1CN[C@H]1CCNC[C@H]1c1ccc(F)cc1.Cl.Cl>>COc1ccc(-c2ccc(C#N)cc2)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccc(F)cc1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CCN(CC)CC.CN(C)C=O.COc1ccc2nccc(C(O)CC[C@@H]3CCN(C4CC(c5ccccc5)C4)C[C@@H]3C(=O)O)c2c1.F[P-](F)(F)(F)(F)F.Oc1cccc2[nH]nnc12.[Cl-].[NH4+]>>COc1ccc2nccc(C(O)CC[C@@H]3CCN(C4CC(c5ccccc5)C4)C[C@@H]3C(N)=O)c2c1",
        "output": "313"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCn1cc(C=O)c(=O)c2c(F)c(OCc3ccc(OC)cc3)c(OCc3ccc(OC)cc3)cc21.ClCCCl.[Na+]>>CCn1cc(CN2CCCC2)c(=O)c2c(F)c(OCc3ccc(OC)cc3)c(OCc3ccc(OC)cc3)cc21",
        "output": "757"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)N1CCNCC1.CCO.O=C(Nc1ccc(CBr)c(C(F)(F)F)c1)C(F)(F)F>>CC(C)(C)N1CCN(Cc2ccc(NC(=O)C(F)(F)F)cc2C(F)(F)F)CC1",
        "output": "248"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)[Si](Oc1ccc(C(=O)Nc2ccc(Cl)cc2)c([N+](=O)[O-])c1)(C(C)C)C(C)C.CCO.Cl[Sn]Cl.O.O>>CC(C)[Si](Oc1ccc(C(=O)Nc2ccc(Cl)cc2)c(N)c1)(C(C)C)C(C)C",
        "output": "486"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCNC(=O)c1cc(Br)cc(C(=O)O)c1.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCCC1CCN(c2ncnc3cc(C(N)=O)sc23)CC1.O=C(O)C(F)(F)F>>CCNC(=O)c1cc(Br)cc(C(=O)NCCC2CCN(c3ncnc4cc(C(N)=O)sc34)CC2)c1",
        "output": "836"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.O.O=C(CCl)Nc1ccc(Cl)cc1C(=O)O.O=C([O-])[O-].O=c1[nH]c2ccccc2n1C1CCNCC1.[I-].[K+].[K+].[Na+]>>O=C(CN1CCC(n2c(=O)[nH]c3ccccc32)CC1)Nc1ccc(Cl)cc1C(=O)O",
        "output": "340"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN1CC[NH+](C)C1Cl.COC1=C(OC)C(=O)C(Cc2cccc(C(=O)O)c2OC(C)=O)=C(C)C1=O.ClCCl.Nc1ccc(S(=O)(=O)C(F)(F)F)cc1.[Cl-]>>COC1=C(OC)C(=O)C(Cc2cccc(C(=O)Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)c2OC(C)=O)=C(C)C1=O",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)CCBr.CC(C)=O.N#Cc1ccc(O)cc1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CC(C)(C)CCOc1ccc(C#N)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NC1CCCCC1.O=C(O)CCC(O)c1ccc(-c2cccc(Cl)c2)cc1>>O=C(O)CCCc1ccc(-c2cccc(Cl)c2)cc1",
        "output": "447"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.ClC(Cl)Cl.O=C(OCc1ccccc1)N1CCN(c2ccc(-c3nnn(CCO)n3)cn2)CC1.[C].[Pd]>>OCCn1nnc(-c2ccc(N3CCNCC3)nc2)n1",
        "output": "428"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(O)c1ccccc1-c1cccs1.c1ccc(-c2ccnc(N3CC4CNCC4C3)n2)cc1>>O=C(c1ccccc1-c1cccs1)N1CC2CN(c3nccc(-c4ccccc4)n3)CC2C1",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccccc1C=O.FC(F)(F)c1nnc2ccc(N3CCNCC3)nn12>>COc1ccccc1CN1CCN(c2ccc3nnc(C(F)(F)F)n3n2)CC1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CNCCO.Clc1ccc(-c2nsc3cc(OCCCCBr)ccc23)cc1>>CN(CCO)CCCCOc1ccc2c(-c3ccc(Cl)cc3)nsc2c1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCCNCC1.CCOC(C)=O.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.Ic1ccc(OCCCN2CCCCC2)cc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Pd].[Pd]>>CC(C)(C)OC(=O)N1CCCN(c2ccc(OCCCN3CCCCC3)cc2)CC1",
        "output": "931"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCn1cnc2[nH]ccc2c1=O.COCCOC.O=C(c1ccc(Cl)cc1)c1ccc(CBr)cc1.[H-].[Na+]>>CCCn1cnc2c(ccn2Cc2ccc(C(=O)c3ccc(Cl)cc3)cc2)c1=O",
        "output": "389"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.CCS(=O)(=O)c1cccc(-c2cc(CN(C)C)cc3[nH]c4ncc(C)cc4c23)c1.CCS(=O)(=O)c1cccc(-c2cc(CO)cc3[nH]c4ncc(C)cc4c23)c1>>CCS(=O)(=O)c1cccc(-c2cc(CN3CCOCC3)cc3[nH]c4ncc(C)cc4c23)c1",
        "output": "765"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COCCOCN(c1noc(C)c1C)S(=O)(=O)c1ccccc1-c1ccc(-c2ncccn2)cc1C=O.[BH4-].[Na+]>>COCCOCN(c1noc(C)c1C)S(=O)(=O)c1ccccc1-c1ccc(-c2ncccn2)cc1CO",
        "output": "356"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(O)Cn1nc(C)c(-c2ccc3c(c2)NC(=O)CO3)c1-c1ccc(F)cc1.CCN(CC)CC.CCOC(C)=O.CS(C)=O.O=S(=O)=O.c1ccncc1>>CCC(=O)Cn1nc(C)c(-c2ccc3c(c2)NC(=O)CO3)c1-c1ccc(F)cc1",
        "output": "87"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CCc1c(Oc2cc(C)cc(C)c2)[nH]c(=O)[nH]c1=O>>CCc1c(Oc2cc(C)cc(C)c2)n(Cc2ccccc2)c(=O)[nH]c1=O",
        "output": "389"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COC(=O)c1ccc(C(=O)NC23C(=O)c4c([N+](=O)[O-])cccc4C2(O)Oc2cc(C(C)C)ccc23)cc1.Cl.O.[Fe]>>COC(=O)c1ccc(C(=O)NC23C(=O)c4c(N)cccc4C2(O)Oc2cc(C(C)C)ccc23)cc1",
        "output": "706"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCCCC.CCCCCCCCOc1c(F)c(F)cc(F)c1F.Cl.O=C=O.[Li]CCCC>>CCCCCCCCOc1c(F)c(F)c(C(=O)O)c(F)c1F",
        "output": "387"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)CCO.CCCCCC.NCc1ccccc1Sc1ccccc1CO.O=C(C1CCCN(c2nc(Cl)nc3ccccc23)C1)N1CCOCC1>>O=C(C1CCCN(c2nc(NCc3ccccc3Sc3ccccc3CO)nc3ccccc23)C1)N1CCOCC1",
        "output": "364"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.CC#N.COc1ccc(-c2ccc3cc(OC)ccc3c2CCCCCCCC(CCCC(F)(F)C(F)(F)F)C(=O)O)cc1.ClCCl.O>>O=C(O)C(CCCCCCCc1c(-c2ccc(O)cc2)ccc2cc(O)ccc12)CCCC(F)(F)C(F)(F)F",
        "output": "20"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOc1ncc(C(=O)O)c2ccccc12.O.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>CCOc1ncc(C(=O)O)c2c([N+](=O)[O-])cccc12",
        "output": "103"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CI.CN(C)C=O.COc1ccc(CN(c2ccon2)S(=O)(=O)c2ccc3c(Cl)n[nH]c(=O)c3c2)cc1.O=C([O-])[O-].[K+].[K+]>>COc1ccc(CN(c2ccon2)S(=O)(=O)c2ccc3c(Cl)nn(C)c(=O)c3c2)cc1",
        "output": "229"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.FC(F)(F)c1cccc(-c2nc(Cl)nc(Cl)n2)n1.Nc1ccnc(C(F)(F)F)c1.O=C([O-])O.[Na+]>>FC(F)(F)c1cc(Nc2nc(Cl)nc(-c3cccc(C(F)(F)F)n3)n2)ccn1",
        "output": "592"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2c3CCCC2)cc1.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl.c1ccncc1>>O=C1CC(=O)N(c2ccc(NS(=O)(=O)c3ccccc3[N+](=O)[O-])cc2)c2ccc3c(c2N1)CCCC3",
        "output": "68"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cncc(C(=O)O)c1.Nc1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1>>CCOC(=O)c1cncc(C(=O)Nc2cnc(OCC(F)(F)F)c(-c3ccc(Cl)cc3)c2)c1",
        "output": "863"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.CCC/C=C\\CCCCCCCO.CCCC/C=C\\CCCCCCCCCC=O.c1ccncc1>>CCC/C=C\\CCCCCCCOC(C)=O",
        "output": "254"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCC.CCN(C(C)C)C(C)C.CCOC(C)=O.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)[C@@H](N)C1CCCCC1.Cl.F[P-](F)(F)(F)(F)F.Nc1cc(Cl)ccc1C(=O)O>>COC(=O)[C@@H](NC(=O)c1ccc(Cl)cc1N)C1CCCCC1",
        "output": "652"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCBr.O.OCc1cccc(CO)n1.[H-].[Na+]>>C=CCOCc1cccc(CO)n1",
        "output": "120"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "B#B.C1CCOC1.C1CCOC1.O.O=C(O)C(Br)c1ccccc1>>OCC(Br)c1ccccc1",
        "output": "231"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCC[N+](CCC)(CCC)CCC.CCOC(C)=O.C[N+]1([O-])CCOCC1.O=[Ru](=O)(=O)[O-].OCc1c[nH]c(-c2ccccn2)c1>>O=Cc1c[nH]c(-c2ccccn2)c1",
        "output": "520"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)Nc1cn2cc(Sc3ccccc3)ccc2n1.O=S(=O)(O)Cl>>COC(=O)Nc1cn2cc(Sc3ccc(S(=O)(=O)Cl)cc3)ccc2n1",
        "output": "182"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C1COCCOCCOCCOCCO1.CCOC(=O)c1cc(-c2ccccc2)[nH]c1F.O.O=S(=O)(Cl)c1ccccc1.[Cl-].[H-].[Na+].[Na+]>>CCOC(=O)c1cc(-c2ccccc2)n(S(=O)(=O)c2ccccc2)c1F",
        "output": "648"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.Cc1cccc(C(O)COc2ccc(CC3SC(=O)NC3=O)cc2)n1.O.c1ccncc1>>CC(=O)OC(COc1ccc(CC2SC(=O)NC2=O)cc1)c1cccc(C)n1",
        "output": "254"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCC1CCCN(C[C@@H]2CCCC[C@H]2N)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O=C(O)CCc1ccc(Cl)cc1>>CCCCC1CCCN(C[C@@H]2CCCC[C@H]2NC(=O)CCc2ccc(Cl)cc2)C1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)C1CNC(=O)N1C.Cl.O.[Li+].[OH-]>>CN1C(=O)NCC1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2cccc(F)c2F)cc1[N+](=O)[O-].[Pd]>>CC(C)(C)OC(=O)Nc1ccc(-c2cccc(F)c2F)cc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=O.CCO.CNCCONC(=O)c1oc2ccncc2c1Nc1ccc(I)cc1F.Cc1ccc(S(=O)(=O)O)cc1.Cl.[BH3-]C#N.[Na+].c1cc[nH+]cc1>>CN(C)CCONC(=O)c1oc2ccncc2c1Nc1ccc(I)cc1F",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCN1CC2C(C1)C2(C)c1cccc(N)c1.O=S(=O)(Cl)CC(F)(F)F.c1ccncc1>>CCCCCCN1CC2C(C1)C2(C)c1cccc(NS(=O)(=O)CC(F)(F)F)c1",
        "output": "194"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1=CCC=CC1.CN(C)C=O.O=C(CNC(c1ccccc1)(c1ccccc1)c1ccccc1)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)OCc1ccccc1.[C].[Pd]>>O=C(O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "186"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)CCCCCCN.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(N=Nc2ccccc2)cc1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>COC(=O)CCCCCCNC(=O)c1ccc(N=Nc2ccccc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.N#Cc1nc(Cl)c(Cl)nc1C#N.O.Oc1ccccc1.[Na+].[OH-]>>N#Cc1nc(Cl)c(Oc2ccccc2)nc1C#N",
        "output": "210"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.Cc1ccc(CCBr)cc1.NC(=O)C(c1ccccc1)(c1ccccc1)C1CCCNC1.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(CCN2CCCC(C(C(N)=O)(c3ccccc3)c3ccccc3)C2)cc1",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CC1(C)OCC(c2ccc(NC(=O)Oc3ccccc3)cn2)O1.CC1CCN(c2nc(C(F)(F)F)ccc2CN)CC1.CN(C)c1ccncc1>>CC1CCN(c2nc(C(F)(F)F)ccc2CNC(=O)Nc2ccc(C3COC(C)(C)O3)nc2)CC1",
        "output": "488"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)C12CC1C=CCCCCN(C)C(=O)N1CC(Oc3cc(-c4ccccc4)nc(OC)n3)CC1C(=O)N2.CO.ClCCl.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li+].[OH-]>>COc1nc(OC2CC3C(=O)NC4(C(=O)O)CC4C=CCCCCN(C)C(=O)N3C2)cc(-c2ccccc2)n1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1c(C(=O)O)ccc2c1S(=O)(=O)CCS2(=O)=O.Cc1ccccc1.O=S(Cl)Cl>>Cc1c(C(=O)Cl)ccc2c1S(=O)(=O)CCS2(=O)=O",
        "output": "3"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc2c(Cl)nc(Nc3cc(C)[nH]n3)cc2c1.COc1cccc(O)c1>>COc1cccc(Oc2nc(Nc3cc(C)[nH]n3)cc3cc(OC)ccc23)c1",
        "output": "516"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1ccc(-c2nc(Cl)c3cc(C)sc3n2)cc1.NCc1ccc(F)cc1>>COC(=O)c1ccc(-c2nc(NCc3ccc(F)cc3)c3cc(C)sc3n2)cc1",
        "output": "906"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc([N+](=O)[O-])cc1-c1nc2cc(Br)ccc2o1.OB(O)c1ccc(F)c(Cl)c1>>COc1ccc([N+](=O)[O-])cc1-c1nc2cc(-c3ccc(F)c(Cl)c3)ccc2o1",
        "output": "909"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cc1ccccc1.N#Cc1cccc(C(=O)O)c1.O=S(Cl)Cl>>N#Cc1cccc(C(=O)Cl)c1",
        "output": "3"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.N#Cc1cnc2ccc([N+](=O)[O-])cc2c1Nc1cccc(Br)c1.O=C([O-])O.[Na+]>>N#Cc1cnc2ccc(N)cc2c1Nc1cccc(Br)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)N.C[Al](C)C.Cc1onc(-c2ccccc2)c1CCc1ccc(C(=O)O)cn1.O=C([O-])[C@H](O)[C@@H](O)C(=O)[O-].[K+].[Na+]>>Cc1onc(-c2ccccc2)c1CCc1ccc(C(=O)NC(C)C)cn1",
        "output": "674"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=[N+]=[N-].CC(C)CCC[C@@H](C)CCC[C@@H](C)C(=O)O.CCOCC>>COC(=O)[C@H](C)CCC[C@H](C)CCCC(C)C",
        "output": "60"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)CC1(O)CCc2c(F)cc(F)cc21.[Na+].[OH-]>>O=C(O)CC1(O)CCc2c(F)cc(F)cc21",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CNCCN1.CN(C)C=O.Cc1cc(Cl)nc2ccccc12.O=C([O-])[O-].[K+].[K+]>>Cc1cc(N2CCNCC2)nc2ccccc12",
        "output": "220"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1=CCN(C)c2c(CO)cccc21.ClCCl.O=S(Cl)Cl>>CC1=CCN(C)c2c(CCl)cccc21",
        "output": "81"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc(NC(=O)OC(C)(C)C)c(F)c(OC)c1.O=C(O)C(F)(F)F>>COc1cc(N)c(F)c(OC)c1",
        "output": "782"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#Cc1ccc(C2(NC(=O)OC(C)(C)C)CCC2)cc1.CCN(CC)CC.COc1ccncc1I.[Cu]I>>COc1ccncc1C#Cc1ccc(C2(NC(=O)OC(C)(C)C)CCC2)cc1",
        "output": "819"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C[C@@H]1CN(c2ccc(Nc3cc(Br)cn(C)c3=O)nc2)CCN1C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F.[Na+].[OH-]>>C[C@@H]1CN(c2ccc(Nc3cc(Br)cn(C)c3=O)nc2)CCN1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N(C)C.CC(C)(C)[O-].Cc1c(O)ccc(N)c1F.Clc1ccnc(Cl)c1.[K+]>>Cc1c(Oc2ccnc(Cl)c2)ccc(N)c1F",
        "output": "351"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1C[C@@H](CCc2c(N)cccc2F)OC[C@H]1COC(=O)NCC(F)(F)F.COc1ccc([C@@H](c2ccccc2)[C@H](N=[N+]=[N-])C(=O)O)cc1Cl.O=P(Cl)(Cl)Cl.c1ccncc1>>COc1ccc([C@@H](c2ccccc2)[C@H](N=[N+]=[N-])C(=O)Nc2cccc(F)c2CC[C@@H]2CN(C(=O)OC(C)(C)C)[C@H](COC(=O)NCC(F)(F)F)CO2)cc1Cl",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)CCN1CCC(N(C)C(=O)Nc2cc(Oc3ccc([N+](=O)[O-])cc3)ncn2)CC1.[C].[OH-].[OH-].[Pd+2]>>CN(C)CCN1CCC(N(C)C(=O)Nc2cc(Oc3ccc(N)cc3)ncn2)CC1",
        "output": "335"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(C#CCO)ccc21.ClCCl.O=C(O)C(F)(F)F>>O=C(O)Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(C#CCO)ccc21",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1cccc(S(=O)(=O)Nc2ccccc2)c1.O=C(O)c1cnn2c(C(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12>>O=C(Nc1cccc(S(=O)(=O)Nc2ccccc2)c1)c1cnn2c(C(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12",
        "output": "969"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cnc(N2CCN(c3cc(-c4ccc(F)cc4)nc(N4CCCC4C)n3)CC2)c(Cl)c1.Cl.O.[Li+].[OH-]>>CC1CCCN1c1nc(-c2ccc(F)cc2)cc(N2CCN(c3ncc(C(=O)O)cc3Cl)CC2)n1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.Cl.O=C([O-])[O-].OC1CC2CCC(C1)N2.OCCBr.[Na+].[Na+]>>OCCN1C2CCC1CC(O)C2",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCC.Cc1ccccc1.Nc1ccccc1C(=O)O.O=CO>>O=CNc1ccccc1C(=O)O",
        "output": "27"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1ncc(N)cc1Br.CCN(C(C)C)C(C)C.Cl.ClCCl.ClCCl.O=C(Cl)c1cccc(F)c1>>CC(C)(C)OC(=O)Nc1ncc(NC(=O)c2cccc(F)c2)cc1Br",
        "output": "501"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cc(-c2csc(N)n2)ccc1F.Cc1cc(Cl)cc(Cl)c1S(=O)(=O)Cl>>Cc1cc(-c2csc(NS(=O)(=O)c3c(C)cc(Cl)cc3Cl)n2)ccc1F",
        "output": "637"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)CO.CN(C)C=O.O.O=[N+]([O-])c1ccc(Cl)cc1.[H-].[Na+]>>CC(C)(C)COc1ccc([N+](=O)[O-])cc1",
        "output": "57"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.O.O=C(O)c1ccc2nccn2c1.O=C([O-])[O-].[Cl-].[Cs+].[Cs+].[Na+]>>COC(=O)c1ccc2nccn2c1",
        "output": "415"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C[C@@H](N)c1ccccc1.O=Cc1ccccc1I>>C[C@@H](NCc1ccccc1I)c1ccccc1",
        "output": "683"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1sc(Br)nc1-c1ccc(Cl)cc1Cl.O.[Na+].[OH-]>>O=C(O)c1sc(Br)nc1-c1ccc(Cl)cc1Cl",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CCCCCCCCCCc1ccc[nH]1.CN(C)C=O.Cl.ClCCCl.O.O.O.O.O=P(Cl)(Cl)Cl.[Na+]>>CCCCCCCCCCc1ccc(C=O)[nH]1",
        "output": "641"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCN(CC)CC.ClCCl.NC(=O)c1cn(CC2CC2)c2ccccc12.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>N#Cc1cn(CC2CC2)c2ccccc12",
        "output": "624"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1cccc2oc(C3=NC(C)(C)CO3)cc12>>CC1(C)COC(c2cc3c(O)cccc3o2)=N1",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(O)CN1CCC(CN(Cc2ccccc2)Cc2ccccc2)CC1.CI.CN(C)C=O.[H-].[Na+]>>COC(C)(C)CN1CCC(CN(Cc2ccccc2)Cc2ccccc2)CC1",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)C(CCCCl)c1ccccc1C(F)(F)F.O=C(O)C(F)(F)F>>O=C(O)C(CCCCl)c1ccccc1C(F)(F)F",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CN1CCCC1=O.COc1cc(F)ccc1-c1cc(N)ncn1.CSCc1cc(Cl)nc(C(F)(F)F)c1.Cc1ccccc1.ClCCl.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>COc1cc(F)ccc1-c1cc(Nc2cc(CSC)cc(C(F)(F)F)n2)ncn1",
        "output": "606"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.N#Cc1c(C=O)cccc1[N+](=O)[O-].[BH4-].[Na+]>>N#Cc1c(CO)cccc1[N+](=O)[O-]",
        "output": "356"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCC(C(=O)OC)c1c(C)nc(Nc2ccccc2)nc1-c1ccc(C)cc1.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc(Nc2ccccc2)nc1-c1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)CC(=O)c1ccnc(C#N)c1.CC(C)(C)OC(=O)Nc1cc(N2CCCC2)c(F)cc1N>>CC(C)(C)OC(=O)Nc1cc(N2CCCC2)c(F)cc1NC(=O)CC(=O)c1ccnc(C#N)c1",
        "output": "929"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=C(O)c1cccc(O)c1.O=S(=O)(O)O>>COC(=O)c1cccc(O)c1",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)c1ccc(Br)cc1.COc1ccc(B(O)O)cc1C=O>>COc1ccc(-c2ccc(N(C)C)cc2)cc1C=O",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN.O=C(N[C@H]1C[C@@H](C(=O)O)N(CC2CCCCC2)C1)c1ccc2ccccc2c1O>>CCNC(=O)[C@@H]1C[C@H](NC(=O)c2ccc3ccccc3c2O)CN1CC1CCCCC1",
        "output": "216"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)N(CCCN)Cc1cccc(-c2ccnc(NCCc3ccc(O)cc3)n2)c1.Cc1ccc(C(=O)O)cc1>>Cc1ccc(C(=O)NCCCN(Cc2cccc(-c3ccnc(NCCc4ccc(O)cc4)n3)c2)S(C)(=O)=O)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.COc1cc(C#CCCCC(O)c2ccc(Cl)c(Cl)c2)ccc1-n1cnc(C)n1.CS(C)=O.O=C([O-])O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>COc1cc(C#CCCCC(=O)c2ccc(Cl)c(Cl)c2)ccc1-n1cnc(C)n1",
        "output": "32"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2C(C)(C)C.CN(C)C=O.Cl.ClCCCN1CCCC1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCCN3CCCC3)cc1CC2C(C)(C)C",
        "output": "74"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc(OC2CCN(C)CC2)c2c(Cl)ncnc2c1.Cc1cccc(N)c1>>COc1cc(OC2CCN(C)CC2)c2c(Nc3cccc(C)c3)ncnc2c1",
        "output": "161"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CC2(CCN1)OCCO2.O=S(=O)(NCCO)c1ccc(F)cc1>>O=S(=O)(NCCO)c1ccc(N2CCC3(CC2)OCCO3)cc1",
        "output": "26"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cc1nc(-c2ccc(Cl)c(C(=O)O)c2)cs1.Cl.NCC1(O)CCCCCC1.On1nnc2ccccc21>>Cc1nc(-c2ccc(Cl)c(C(=O)NCC3(O)CCCCCC3)c2)cs1",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COCCOc1ccc(C#N)c(C)c1.Cl.NO.O=C([O-])O.[Na+]>>COCCOc1ccc(C(=N)NO)c(C)c1",
        "output": "854"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.N#CCc1ccc(C(=O)c2ccc(Cl)cc2)n1Cc1ccccc1.O.[Na+].[OH-]>>O=C(O)Cc1ccc(C(=O)c2ccc(Cl)cc2)n1Cc1ccccc1",
        "output": "259"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCN(CCCC)CCCC.CCOC(C)=O.C[C@@H]1CN(Cc2ccccc2)C[C@H](C)N1.Cc1ccccc1.Clc1nccnc1Cl.c1ccc(Oc2ccccc2)cc1>>C[C@@H]1CN(Cc2ccccc2)C[C@H](C)N1c1nccnc1Cl",
        "output": "505"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CO.CSc1nc2ccc(CNc3ccc(Br)cc3[N+](=O)[O-])cc2o1.ClCCl.[Zn]>>CSc1nc2ccc(CNc3ccc(Br)cc3N)cc2o1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.CN(C)CC1C(N)C2CCN1CC2.COc1cc(N)c(Cl)cc1C(=O)O.ClCCl>>COc1cc(N)c(Cl)cc1C(=O)NC1C2CCN(CC2)C1CN(C)C",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCc2cn(-c3ccc(S(C)(=O)=O)cc3)nc2CC1.CO.Cl>>CS(=O)(=O)c1ccc(-n2cc3c(n2)CCNCC3)cc1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CNC1.CC(C)N1CCC(Oc2ccc(C3(C(=O)O)CCOCC3)cc2)CC1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.ClCCl.O.On1nnc2ccccc21>>CC(C)N1CCC(Oc2ccc(C3(C(=O)N4CCC4)CCOCC3)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)COc1ccc(C(=O)c2[nH]c(=O)[nH]c2C)cc1.O.[K+].[OH-]>>Cc1[nH]c(=O)[nH]c1C(=O)c1ccc(OCC(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)[O-].CO.COC(=O)[C@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3C)CC2)CC1.COC(C)(C)C.O.O.[Li+].[NH4+].[OH-]>>Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.N#Cc1ccc(O)cc1Cl.[H-].[Na+]>>COc1ccc(C#N)c(Cl)c1",
        "output": "62"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Oc1c(F)cc(Br)cc1Cl>>CC1(C)OB(c2cc(F)c(O)c(Cl)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCN(CC(=O)O)c1cc(Br)c(C#N)s1.CNC.Cc1ccccc1.O.O=S(Cl)Cl>>CCCN(CC(=O)N(C)C)c1cc(Br)c(C#N)s1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cl.N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3OCO4)CC2)CC1.O=C(O)c1ccnc2ccccc12>>O=C(N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3OCO4)CC2)CC1)c1ccnc2ccccc12",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCCC1CN(C2CCOCC2)C(=O)N1C1CCNCC1.Cc1nc(Sc2ccc(OCC(=O)OC(C)(C)C)cc2)ccc1C=O.ClCCl.[Na+]>>CCCCC1CN(C2CCOCC2)C(=O)N1C1CCN(Cc2ccc(Sc3ccc(OCC(=O)OC(C)(C)C)cc3)nc2C)CC1",
        "output": "757"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CC(C)OC(=O)c1cccnc1N1CC[C@H](N)C1.CCc1ccc(CBr)cc1.O=C([O-])[O-].[K+].[K+]>>CCc1ccc(CN[C@H]2CCN(c3ncccc3C(=O)OC(C)C)C2)cc1",
        "output": "446"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(Nc2ncnc3cc(OC(C)=O)cc(OC4CCOCC4)c23)c(Cl)cc1Cl.N>>COc1cc(Nc2ncnc3cc(O)cc(OC4CCOCC4)c23)c(Cl)cc1Cl",
        "output": "22"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc2c(N)cc(=O)[nH]c2c1OC1CCCC1.CS(C)=O.Clc1cncc(Cl)c1Cl.O=P([O-])(O)O.[H-].[K+].[Na+]>>COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)[nH]c2c1OC1CCCC1",
        "output": "115"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CC(=O)[O-].Cc1ccccc1.Fc1ccc(C(F)(F)F)cc1Br.O.O=C([O-])[O-].OC1CCNC1.[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>OC1CCN(c2cc(C(F)(F)F)ccc2F)C1",
        "output": "294"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1ccccc1-c1noc(C)c1C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>COC(=O)c1ccccc1-c1noc(C)c1C(=O)O",
        "output": "569"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClP(Cl)(Cl)(Cl)Cl.O=P(Cl)(Cl)Cl.O=[N+]([O-])c1cnc(O)c(Cl)c1>>O=[N+]([O-])c1cnc(Cl)c(Cl)c1",
        "output": "41"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(C[C@H]2NC(=O)n3c2nc2ccccc23)cc1.NC1CCCCCC1.O=C(O)C(F)(F)F>>COc1ccc(C[C@@H](NC(=O)NC2CCCCCC2)c2nc3ccccc3[nH]2)cc1",
        "output": "999"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCN1CC(c2ccc(N)cc2)C1.ClCCl.O=S(=O)(Cl)c1ccc(CCCF)cc1.c1ccncc1>>CCCN1CC(c2ccc(NS(=O)(=O)c3ccc(CCCF)cc3)cc2)C1",
        "output": "68"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2oc3ccc(Cl)nc3c2C)C2CCCCC2)cc1.[Li+].[OH-]>>Cc1c(C(Nc2ccc(C(=O)N(C)CCC(=O)O)cc2)C2CCCCC2)oc2ccc(Cl)nc12",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1.O=C(O)Cc1c(Cl)cccc1Cl.O=S(Cl)Cl>>O=C(Cc1c(Cl)cccc1Cl)Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1",
        "output": "365"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1NCCc2c1cccc2C(F)(F)F.O=C(O)c1cc2ncc(Cl)cn2n1>>CN1c2cccc(C(F)(F)F)c2CCN1C(=O)c1cc2ncc(Cl)cn2n1",
        "output": "995"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCS(=O)(=O)c1cnc(N2CCNCC2)s1.CS(=O)(=O)c1ccc(N2CCOCC2)c(C(=O)O)c1.Cl>>CCCCS(=O)(=O)c1cnc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3N3CCOCC3)CC2)s1",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CCOc1ccc(-n2c([C@@H](C)N(CCC(C)NC3CCC3)C(=O)Cc3ccc(F)c(C(F)(F)F)c3)nc3ncccc3c2=O)cc1.ClCCl.[Na+]>>CCOc1ccc(-n2c([C@@H](C)N(CCC(C)N(C)C3CCC3)C(=O)Cc3ccc(F)c(C(F)(F)F)c3)nc3ncccc3c2=O)cc1",
        "output": "217"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cn1cc(-c2nc3c(-c4ccc(CN)c(F)c4)ccnc3[nH]2)cn1.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(C2CC2)nc1>>Cn1cc(-c2nc3c(-c4ccc(CNC(=O)c5ccc(C6CC6)nc5)c(F)c4)ccnc3[nH]2)cn1",
        "output": "790"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)C1=Cc2cc(Cl)c(Oc3cc(C)c(C)cc3Cl)cc2OC1C(F)(F)F.CCOCC.CO.Cl.O.O.[Al].[Li+].[OH-]>>Cc1cc(Cl)c(Oc2cc3c(cc2Cl)C=C(C(=O)O)C(C(F)(F)F)O3)cc1C",
        "output": "122"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.NC1CC1.Nc1nc(Cl)ccc1C(=O)NCc1ccc(OCc2ccccc2)cc1>>Nc1nc(NC2CC2)ccc1C(=O)NCc1ccc(OCc2ccccc2)cc1",
        "output": "70"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].C[C@H](N)c1ccccc1.Cc1ccc(C2c3c(C)c(Br)c(C)c(C)c3OC2(C)C)cc1.Cc1ccccc1.Cl.[Na+].[Pd+2]>>Cc1ccc(C2c3c(C)c(N[C@@H](C)c4ccccc4)c(C)c(C)c3OC2(C)C)cc1",
        "output": "932"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)c1ccc(CCN)c(OCc2ccccc2)c1>>CC(C)c1ccc(CCNC(=O)OC(C)(C)C)c(OCc2ccccc2)c1",
        "output": "631"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Oc1c(F)cc(-c2cccc(C=O)c2)cc1C12CC3CC(CC(C3)C1)C2.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>O=Cc1cccc(-c2cc(F)c(O)c(C34CC5CC(CC(C5)C3)C4)c2)c1",
        "output": "754"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCNCC1.COc1ccc2c(ccn2S(=O)(=O)c2ccccc2)c1C=O.ClCCl.O=C([O-])[O-].[Na+].[Na+].[Na+]>>COc1ccc2c(ccn2S(=O)(=O)c2ccccc2)c1CN1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "567"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cccc(CN)c4)cc23)CC1.CN(C)C=O.ClCCl.O=S(=O)(Cl)c1cc(Cl)ccc1Cl>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cccc(CNS(=O)(=O)c5cc(Cl)ccc5Cl)c4)cc23)CC1",
        "output": "530"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCC(C#N)CCC.O=S(=O)(O)O>>CCCC(CCC)C(N)=O",
        "output": "8"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(O)(CC#N)c1cccc(Cl)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC(O)(CCN)c1cccc(Cl)c1",
        "output": "246"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.O.O=C1CC(CNCC(F)(F)F)CN1Cc1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>FC(F)(F)CNCC1CCN(Cc2ccccc2)C1",
        "output": "533"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=C(NCc1nc(-c2ccncc2)c[nH]1)OCc1ccccc1.[Pd]>>NCc1nc(-c2ccncc2)c[nH]1",
        "output": "574"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)c1ncccc1SCc1ccc(OC)cc1.[Na+].[OH-]>>COc1ccc(CSc2cccnc2C(=O)O)cc1",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.NCc1nnc(-c2ccc(OCc3ccccc3)cc2)o1.O=C(O)C(O)CCCCCOc1cccc(F)c1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>O=C(NCc1nnc(-c2ccc(OCc3ccccc3)cc2)o1)C(O)CCCCCOc1cccc(F)c1",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNCC1.COC1=C(OC)C(=O)C(Cc2cccc(CCC(=O)O)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2cccc(CCC(=O)N3CCCCC3)c2)=C(C)C1=O",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1[nH]c2ccc(Cl)cc2c1C.CO.[Na+].[OH-]>>Cc1c(C(=O)O)[nH]c2ccc(Cl)cc12",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CNc1nc(SC)ncc1C.CO.ClCCl.ClCCl.O=C(OO)c1cccc(Cl)c1>>CNc1nc(S(C)=O)ncc1C",
        "output": "595"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(C(=O)Cl)cc1.O.c1ccc2cc(N3CCNCC3)ncc2c1.c1ccncc1>>COc1ccc(C(=O)N2CCN(c3cc4ccccc4cn3)CC2)cc1",
        "output": "201"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C[AlH]CC(C)C.COc1ccc2nccc(-n3cc4c(n3)CCC(NC(=O)CCc3ccc(Cl)c(Cl)c3)C4)c2n1.ClCCl.O.O=C([O-])C(O)C(O)C(=O)[O-].[K+].[Na+]>>COc1ccc2nccc(-n3cc4c(n3)CCC(NCCCc3ccc(Cl)c(Cl)c3)C4)c2n1",
        "output": "112"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=Cc1cccc(O)c1.OCCO>>Oc1cccc(C2OCCO2)c1",
        "output": "117"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CCS(N)(=O)=O.CN(C)c1ccccn1.Cl.ClCCl.O=C(O)Cc1c(-c2ccc(Cl)c(S(=O)(=O)NC3CCCCC3)c2)[nH]c2ccccc12>>CCS(=O)(=O)NC(=O)Cc1c(-c2ccc(Cl)c(S(=O)(=O)NC3CCCCC3)c2)[nH]c2ccccc12",
        "output": "644"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1NCCc2ccc(-c3ccncc3)cc21.O=C(O)c1cc2ncc(Br)cn2n1>>CN1c2cc(-c3ccncc3)ccc2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "995"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(C)=O.Cc1cc(-c2nc3cnccc3c(=O)n2NCc2ccc(Cl)cc2)ccc1[N+](=O)[O-].[Pd]>>Cc1cc(-c2nc3cnccc3c(=O)n2NCc2ccc(Cl)cc2)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)Cl.COC(=O)OC1CCCCc2cc(N)cnc21.ClCCl.c1ccncc1>>CCOC(=O)Nc1cnc2c(c1)CCCCC2OC(=O)OC",
        "output": "763"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCl.OCCc1cccc(CO)c1.[Mn+4].[O-2].[O-2]>>O=Cc1cccc(CCO)c1",
        "output": "179"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(O)c1ccc(F)cc1.CCN(CC)CC.COc1cc2ncnc(Oc3ccc(N)c(Cl)c3)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2ncnc(Oc3ccc(NC(=O)OC(C)c4ccc(F)cc4)c(Cl)c3)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CNC.ClCCl.O=S(=O)(Cl)c1ccc(F)cc1>>CN(C)S(=O)(=O)c1ccc(F)cc1",
        "output": "99"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)n1c(-c2cccc3c2C(=O)NC3)cc2cc(OCc3ccccc3)ccc21.CCOC(C)=O.[Pd]>>CC(C)(C)OC(=O)n1c(-c2cccc3c2C(=O)NC3)cc2cc(O)ccc21",
        "output": "23"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CN(c1nc(Cl)ncc1Cl)C1CCN(c2ccc(C#N)cn2)CC1.CO.Cc1nn(C)cc1N.Cl.ClCCl>>Cc1nn(C)cc1Nc1ncc(Cl)c(N(C)C2CCN(c3ccc(C#N)cn3)CC2)n1",
        "output": "992"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCO.CCOC(=O)C1=C(OC(CC)CCN=[N+]=[N-])CCC(OS(C)(=O)=O)C1.ClCCl.[H][H].[Pb+2].[Pd]>>CCOC(=O)C1=C(OC(CC)CCN)CCC(OS(C)(=O)=O)C1",
        "output": "89"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCC1CCC1.CC#N.COC(=O)c1coc(-c2ccc(-c3nc4ccccc4[nH]3)cc2)n1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1coc(-c2ccc(-c3nc4ccccc4n3CC3CCC3)cc2)n1",
        "output": "276"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N1CCN(CCCO)CC1.CCOC(=O)N=NC(=O)OCC.COc1cc2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2cc1O.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2cc1OCCCN1CCN(C(C)=O)CC1",
        "output": "478"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)CC(O)CC(C)(C)N1.CCCCCCCCCCCCCCOC(=O)Cl.Cl.ClCCl.O.[Na+].[OH-]>>CCCCCCCCCCCCCCOC(=O)OC1CC(C)(C)NC(C)(C)C1",
        "output": "144"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1ccc(CN2CCCN(Cc3ccc([N+](=O)[O-])cc3)C2=O)cc1.CO.[H][H]>>CC(C)(C)c1ccc(CN2CCCN(Cc3ccc(N)cc3)C2=O)cc1",
        "output": "507"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCN=C=O.CCO.CN(C)CCCN1CN(CCCN(C)C)CN(CCCN(C)C)C1.[N-]=C=O>>CCCCNC(=O)OCC",
        "output": "235"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.COc1ccc(SC2Cc3ccccc3C2)cc1.ClCCl.O>>Oc1ccc(SC2Cc3ccccc3C2)cc1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CB(O)O.Cc1nc(C)c2c(n1)CCN(C(=O)OCc1ccccc1)C2.Cc1nc(Cl)c2c(n1)CCN(C(=O)OCc1ccccc1)C2.Cl[Pd]Cl.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1nc(C)c2c(n1)CCNC2",
        "output": "428"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C(O)c1cccc(O)c1.O=C=NCC1CCCCC1>>O=C(NCC1CCCCC1)Oc1cccc(C(=O)O)c1",
        "output": "104"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(C)=O.O.O=[N+]([O-])c1ccc2oc(SCc3ccc(Cl)cc3)nc2c1.[Cl-].[Fe].[NH4+]>>Nc1ccc2oc(SCc3ccc(Cl)cc3)nc2c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCO.Clc1nccc(I)c1Cl.NN.O.[NH4+].[OH-]>>NNc1nccc(I)c1Cl",
        "output": "417"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.CCNCCO.CN(C[C@@H]1CC[C@@H](COCCCCBr)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1>>CCN(CCO)CCCCOC[C@@H]1CC[C@@H](CN(C)S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccccc1C(F)F.ClC(Cl)(Cl)Cl.ClCCl.O=C1CCC(=O)N1Br>>FC(F)c1ccccc1CBr",
        "output": "29"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1ccc(C(=O)Nc2ccc(N3CCNCC3)cc2)c(-c2ccc(C(C)C)cc2)c1.ClCCCl.O=Cc1ccc[nH]1.[Na+]>>Cc1ccc(C(=O)Nc2ccc(N3CCN(Cc4ccc[nH]4)CC3)cc2)c(-c2ccc(C(C)C)cc2)c1",
        "output": "829"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)CC1Cc1ccc2ccccc2c1.ClCCl.O=C(O)C(F)(F)F.[NH4+].[OH-]>>c1ccc(CN2CCNC(Cc3ccc4ccccc4c3)C2)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCc1ncn(C[C@H]2NC(=O)[C@H]2N)n1.CC(C)(C)OC(=O)Nc1nc(/C(=N/OC(C)(C)C(=O)OC(C)(C)C)C(=O)O)cs1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.ClCCl.F[P-](F)(F)(F)(F)F.O>>CC(C)(C)OC(=O)NCc1ncn(C[C@H]2NC(=O)[C@H]2NC(=O)/C(=N\\OC(C)(C)C(=O)OC(C)(C)C)c2csc(NC(=O)OC(C)(C)C)n2)n1",
        "output": "587"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)C1CCN(C(=O)OC(C)(C)C)CC1.O.O.O.[Li]O>>CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.CO.ClCCl.ClCc1ccc2c(c1)OCO2.O=C([O-])[O-].[I-].[K+].[K+].[Na+].c1cn(-c2ccc(NC3CCCNC3)cc2)cn1>>c1cn(-c2ccc(NC3CCCN(Cc4ccc5c(c4)OCO5)C3)cc2)cn1",
        "output": "156"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1ccn(-c2ccc(Cl)cc2OC)c1-c1ccc(C#N)cc1C.CCOC(C)=O.CO.CS(C)=O.OO.[Na+].[OH-]>>CCOC(=O)c1ccn(-c2ccc(Cl)cc2OC)c1-c1ccc(C(N)=O)cc1C",
        "output": "180"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cn1c(C(C)(C)C)c(-c2ccccc2)c2cc(O)ccc2c1=O.ICCCCc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+]>>Cn1c(C(C)(C)C)c(-c2ccccc2)c2cc(OCCCCc3ccccc3)ccc2c1=O",
        "output": "198"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CC[C@H]1CN(c2nc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3n2CC(F)(F)F)CCN1.CS(=O)(=O)Cl.ClCCl>>CC[C@H]1CN(c2nc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3n2CC(F)(F)F)CCN1S(C)(=O)=O",
        "output": "584"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(CC)CC.O=C(O)c1ccc(-c2cnco2)cc1.[NH4+].[OH-]>>NC(=O)c1ccc(-c2cnco2)cc1",
        "output": "358"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl.O=C(O)c1ccccc1OCc1ccccc1.OCCCBr>>O=C(OCCCBr)c1ccccc1OCc1ccccc1",
        "output": "33"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(C(=O)Cl)cc1.ClCCl.NCc1ccc(N)cc1>>COc1ccc(C(=O)NCc2ccc(N)cc2)cc1",
        "output": "411"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Nc1ccc2c(c1)[nH]c1cc(O)ccc12.CCOC(C)=O.CN1CCCC1=O.Cc1ccc(S(=O)(=O)OCCOCCOCCF)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)(C)OC(=O)Nc1ccc2c(c1)[nH]c1cc(OCCOCCOCCF)ccc12",
        "output": "438"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)n1ccc2c(NC(=O)C3CCN(C(=O)OCc4ccccc4)CC3)ccnc21.CO.[C+4].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Pd+2]>>CC(C)(C)OC(=O)n1ccc2c(NC(=O)C3CCNCC3)ccnc21",
        "output": "428"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)CONC(=O)OC(C)(C)C.Cl.[K+].[OH-]>>CC(C)(C)OC(=O)NOCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1CN(C)CCc2cc(Cl)c(Cl)cc21.CC1CN(C)CCc2cc(F)c(Cl)cc21.CC1CN(C)CCc2ccc(Br)cc21.CC1CN(C)CCc2ccc(C(F)(F)F)cc21.CC1CN(C)CCc2ccc(I)cc21.CCC1CN(C)CCc2cc(Cl)c(Cl)cc21.CCC1CN(C)CCc2cc(F)c(Cl)cc21.CCC1CN(C)CCc2ccc(Br)cc21.CCC1CN(C)CCc2ccc(C(F)(F)F)cc21.CCC1CN(C)CCc2ccc(Cl)cc21.CCC1CN(C)CCc2ccc(I)cc21>>CC1CN(C)CCc2ccc(Cl)cc21",
        "output": "253"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CCS(=O)(=O)Cl.Cl.N[C@H]1CCC(F)(F)C[C@@H]1COc1ccc(N2CCCC2=O)cc1>>CCS(=O)(=O)N[C@H]1CCC(F)(F)C[C@@H]1COc1ccc(N2CCCC2=O)cc1",
        "output": "493"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCOCC(=O)Cl.Cc1cc(NCCOCc2ccccc2)c(N)c(Oc2ccccc2)n1.ClCCl>>CCOCC(=O)Nc1c(NCCOCc2ccccc2)cc(C)nc1Oc1ccccc1",
        "output": "422"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNC1.CCC(=O)Nc1ccc(Sc2nc(CCBr)cc(Nc3cc(C)[nH]n3)n2)cc1.CCOC(C)=O.CN(C)C=O>>CCC(=O)Nc1ccc(Sc2nc(CCN3CCC3)cc(Nc3cc(C)[nH]n3)n2)cc1",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.CCN(C(C)C)C(C)C.Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC1CNCC1O>>CC(=O)N1CC(O)C(NC(=O)c2c(C)[nH]c(/C=C3\\C(=O)Nc4ccc(F)cc43)c2C)C1",
        "output": "125"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOC(C)=O.CN(C)C=O.COC(=O)c1cc(Cl)c(OCC23CC4CC(CC(CO)(C4)C2)C3)cc1F.c1c[nH]cn1>>COC(=O)c1cc(Cl)c(OCC23CC4CC(C2)CC(CO[Si](C)(C)C(C)(C)C)(C4)C3)cc1F",
        "output": "193"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CCN=C=NCCCN(C)C.COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCNCC4)cc3)nc2c1.Cl.O=C(O)CC(F)(F)F.On1nnc2ccccc21>>COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCN(C(=O)CC(F)(F)F)CC4)cc3)nc2c1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C(=O)O)S(C)(=O)=O.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1cc(Nc2ncnc3ccn(CCN)c23)ccc1Oc1cccc(Cl)c1.Cl.Cl.Cl.O.On1nnc2ccccc21>>Cc1cc(Nc2ncnc3ccn(CCNC(=O)C(C)(C)S(C)(=O)=O)c23)ccc1Oc1cccc(Cl)c1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCNCC1.CCOC(C)=O.COc1nc(Cl)nc(Nc2ccc(-n3cnc(C)c3)c(OC)c2)n1>>COc1nc(Nc2ccc(-n3cnc(C)c3)c(OC)c2)nc(N2CCCCC2)n1",
        "output": "214"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)C(F)(F)CC(=O)[O-].ClCCl>>COC(=O)C(F)(F)CCO",
        "output": "231"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN(C)C=O.CN1C(=O)C(O)=C2C(=O)N(Cc3ccc(F)cc3)CCC2C1C(=O)O.CNC.Cl.ClCCCl.On1nnc2ccccc21>>CN(C)C(=O)C1C2CCN(Cc3ccc(F)cc3)C(=O)C2=C(O)C(=O)N1C",
        "output": "685"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.CCOC(C)=O.COc1c(F)ccc(C(Nc2cccc3nc(C)ccc23)C(O)(CCl)C(F)(F)F)c1F.ClCCl.O=C([O-])O.[Na+]>>Cc1ccc2c(NC(c3ccc(F)c(O)c3F)C(O)(CCl)C(F)(F)F)cccc2n1",
        "output": "732"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](C)(C)Cl.ClCCl.OC1(c2ccc(Br)cc2F)CC1>>CC(C)(C)[Si](C)(C)OC1(c2ccc(Br)cc2F)CC1",
        "output": "193"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(=O)(=O)Cl.CSc1ncc2ccc(-c3ccc(C)cc3N)n2n1.Cl.c1ccncc1>>CSc1ncc2ccc(-c3ccc(C)cc3NS(C)(=O)=O)n2n1",
        "output": "194"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1Cc1ccc(C2=NOC(c3cc(Br)cc(C(F)(F)F)c3)(C(F)(F)F)C2)cc1Cl>>NCc1ccc(C2=NOC(c3cc(Br)cc(C(F)(F)F)c3)(C(F)(F)F)C2)cc1Cl",
        "output": "418"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Brc1ccc2c(c1)c(-c1nc3ccccc3[nH]1)nn2C1CCCCO1.C1CCOC1.CC(=O)[O-].CC(=O)[O-].CS(=O)(=O)c1cccc(B(O)O)c1.O=C([O-])[O-].[Na+].[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CS(=O)(=O)c1cccc(-c2ccc3c(c2)c(-c2nc4ccccc4[nH]2)nn3C2CCCCO2)c1",
        "output": "837"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)CCNS(=O)(=O)c1cccc(Nc2ncc([N+](=O)[O-])cn2)c1.CO>>CN(C)CCNS(=O)(=O)c1cccc(Nc2ncc(N)cn2)c1",
        "output": "660"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Nc1ccc(Cl)cc1C(F)(F)F.O=C(O)c1cc(Cl)ccc1O>>O=C(Nc1ccc(Cl)cc1C(F)(F)F)c1cc(Cl)ccc1O",
        "output": "50"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCO.CCOCC.CCc1cncc(Cl)c1CBr.Oc1cc(C(F)(F)F)nc(S)n1>>CCc1cncc(Cl)c1CSc1nc(O)cc(C(F)(F)F)n1",
        "output": "699"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cl.Cl.NC(c1ccc2c(cnn2-c2ccc(F)cc2)c1)C(F)(F)F.Nc1cc(Cl)cc(Cl)c1S(=O)(=O)Cl.c1ccncc1>>Nc1cc(Cl)cc(Cl)c1S(=O)(=O)NC(c1ccc2c(cnn2-c2ccc(F)cc2)c1)C(F)(F)F",
        "output": "530"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)P(C(C)(C)C)C(C)(C)C.CCOC(=O)c1cncc(B2OC(C)(C)C(C)(C)O2)c1.CN(C)C=O.O=C([O-])[O-].OC1CCN(c2ccc(Br)cn2)CC1.[Br-].[Cs+].[Cs+].[Pd+]>>CCOC(=O)c1cncc(-c2ccc(N3CCC(O)CC3)nc2)c1",
        "output": "967"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)C[AlH]CC(C)C.COC(=O)c1ccc2nc(Br)nn2c1.ClCCl>>OCc1ccc2nc(Br)nn2c1",
        "output": "522"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)C(F)(F)Sc1ncc(Br)n1-c1ccc(C#N)c2ccccc12.O.[Li+].[OH-]>>N#Cc1ccc(-n2c(Br)cnc2SC(F)(F)C(=O)O)c2ccccc12",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)CN1C(=O)[C@H](N)Cc2ccccc21.O=C(O)c1cc2cc(Cl)ncc2[nH]1.On1nnc2ccccc21>>COC(=O)CN1C(=O)[C@H](NC(=O)c2cc3cc(Cl)ncc3[nH]2)Cc2ccccc21",
        "output": "738"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1ccc(-n2ncc(C(=O)NC3C4CC5CC(C4)CC3C5)c2SC2CCCCC2)cc1.[Na+].[OH-]>>O=C(O)c1ccc(-n2ncc(C(=O)NC3C4CC5CC(C4)CC3C5)c2SC2CCCCC2)cc1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(=O)O.CC(C)(C)[O-].CN1CCCC1=O.Clc1nc2ccccc2c2ccccc12.[Na+]>>CC(C)(C)OC(=O)N1C[C@H](Oc2nc3ccccc3c3ccccc23)C[C@H]1C(=O)O",
        "output": "433"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(N)cn1.Cc1ccc(NC(=O)Oc2ccccc2)cn1.Cl.FC(F)(F)c1ccc(Oc2cccc(C=C3CCNCC3)c2)nc1>>Cc1ccc(NC(=O)N2CCC(=Cc3cccc(Oc4ccc(C(F)(F)F)cn4)c3)CC2)cn1",
        "output": "525"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCCCCCCCP(=O)(O)CCCNC(=O)OCc1ccccc1.Cl>>CCCCCCCCCCCCP(=O)(O)CCCN",
        "output": "574"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CS(=O)(=O)OCCc1ccc(N2CCOCC2)cc1.O=C([O-])[O-].OC[C@H]1CCCN1.[Na+].[Na+]>>OC[C@H]1CCCN1CCc1ccc(N2CCOCC2)cc1",
        "output": "496"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[O-].CCOC(C)=O.CN(C)C=O.O=S(=O)(Nc1nccs1)c1ccc2c(-c3ccc(C(F)(F)F)cc3F)nccc2c1.[K+].c1c[nH]cn1>>O=S(=O)(Nc1nccs1)c1ccc2c(-c3ccc(C(F)(F)F)cc3-n3ccnc3)nccc2c1",
        "output": "701"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CNC.COc1cc(Nc2nc3n(n2)CCC(=O)CC3c2ccc(F)cc2)ccc1-n1cnc(Cl)c1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.[BH3-]C#N.[Na+]>>COc1cc(Nc2nc3n(n2)CCC(N(C)C)CC3c2ccc(F)cc2)ccc1-n1cnc(Cl)c1",
        "output": "187"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CN(C)C=O.Cc1ccccc1-c1c(Cl)ccc(C=O)c1O.[H-].[Na+]>>Cc1ccccc1-c1c(Cl)ccc(C=O)c1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCOC(C)=O.O=C(O)CNC(=O)c1ccc([N+](=O)[O-])c(F)c1.[Fe]>>Nc1ccc(C(=O)NCC(=O)O)cc1F",
        "output": "28"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(Sc1nnn[nH]1)C1=C(C(=O)O)N2C(=O)C(N)[C@H]2SC1.CN(C)C=O.CON=C(C(=O)O)c1nsc(NC=O)n1.C[Si](C)(C)CC(N)=O.ClCCl.O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+]>>CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(C(C)Sc3nnn[nH]3)CS[C@H]12)c1nsc(NC=O)n1",
        "output": "587"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(C)=O.Cc1ccc(OCc2ccccc2)cc1CO.O.O=C(O)c1ccccc1I(=O)=O>>Cc1ccc(OCc2ccccc2)cc1C=O",
        "output": "179"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC=COc1ccc([N+](=O)[O-])cc1.Cl.O.[Fe].[Na+].[OH-]>>CCC=COc1ccc(N)cc1",
        "output": "202"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CCCCCCCBr.COc1ccc(-c2nc[nH]c2-c2ccc(OC)cc2)cc1>>CCOC(=O)CCCCCCCn1cnc(-c2ccc(OC)cc2)c1-c1ccc(OC)cc1",
        "output": "276"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrC(Br)(Br)Br.OCCCCCCC1=C(c2ccccc2)CCCc2c1ccc(O)c2Cl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Oc1ccc2c(c1Cl)CCCC(c1ccccc1)=C2CCCCCCBr",
        "output": "378"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1cn2c(n1)C(C)NCC2.O=C(O)c1cc2ncc(Cl)cn2n1>>CCOC(=O)c1cn2c(n1)C(C)N(C(=O)c1cc3ncc(Cl)cn3n1)CC2",
        "output": "663"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CSCCC(=O)Cl.ClCCl.Nc1cccc(C#Cc2cncnc2Nc2ccc(OCc3cccc(F)c3)c(Cl)c2)c1>>CSCCC(=O)Nc1cccc(C#Cc2cncnc2Nc2ccc(OCc3cccc(F)c3)c(Cl)c2)c1",
        "output": "9"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)C=Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1.[Na+].[OH-]>>COc1ccc(C[C@H](NC(=O)C=Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(O)CN.CCN(C(C)C)C(C)C.CS(C)=O.FC(F)(F)Oc1cccc(-c2cnc3ccc(Cl)nn23)c1.[Cs+].[F-]>>CC(C)(O)CNc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1",
        "output": "241"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1cc(S(C)(=O)=O)c(Cl)cc1C.Cl>>Cc1cc(Cl)c(S(C)(=O)=O)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.BrBr.CC1(C)C(=O)Nc2ccccc21.ClC(Cl)Cl>>CC1(C)C(=O)Nc2ccc(Br)cc21",
        "output": "98"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=NO)C(C)=NO.CC(=O)O.CN(C)C=O.O.O=C1NC(=O)C(=Cc2ccc(OCC3CCCC3)cc2)S1.[BH4-].[Na+].[Na+].[OH-]>>O=C1NC(=O)C(Cc2ccc(OCC3CCCC3)cc2)S1",
        "output": "762"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)CN(Cc2ccccc2)CCC1=O.CO.[BH4-].[Na+]>>CC1(C)CN(Cc2ccccc2)CCC1O",
        "output": "91"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1cc(C#N)c(OC)nc1C.CO.Cl.[Pd]>>CCc1cc(CN)c(OC)nc1C",
        "output": "560"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN1CCCC1=O.COC(=O)Cc1ccccc1Br.[K+]>>COC(=O)Cc1ccccc1B1OC(C)(C)C(C)(C)O1",
        "output": "942"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)C(Cc1ccc(OCCNC(=O)c2ccc(-c3ccccn3)cc2)cc1)Oc1cccc(F)c1.[Na+].[OH-]>>O=C(NCCOc1ccc(CC(Oc2cccc(F)c2)C(=O)O)cc1)c1ccc(-c2ccccn2)cc1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.[N-]=[N+]=NC1(c2ccccc2)CCC2(CC1)OCCO2.[Pd]>>NC1(c2ccccc2)CCC2(CC1)OCCO2",
        "output": "562"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1noc(C2CCNCC2)n1.CC1(C)OCC(c2ccc(Oc3ncnc(Cl)c3[N+](=O)[O-])cc2)CO1.Cl.ClCCl>>CC(C)c1noc(C2CCN(c3ncnc(Oc4ccc(C5COC(C)(C)OC5)cc4)c3[N+](=O)[O-])CC2)n1",
        "output": "296"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)c1ccncc1.O=C(O)c1ccc2cc[nH]c2c1>>CC(C)(C)OC(=O)n1ccc2ccc(C(=O)O)cc21",
        "output": "748"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C[C@H](CC1CCCCC1)NC(=O)c1cccc(N(CCCNC(=O)OC(C)(C)C)c2cccc(Cl)c2)c1)C(=O)OCC[Si](C)(C)C.CO.Cc1ccc(S(=O)(=O)O)cc1.O>>CN(C[C@H](CC1CCCCC1)NC(=O)c1cccc(N(CCCN)c2cccc(Cl)c2)c1)C(=O)OCC[Si](C)(C)C",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(F)c2[nH]c3ccccc3c12.Cl.[NH4+].[OH-].c1ccncc1>>Oc1ccc(F)c2[nH]c3ccccc3c12",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCBr.CCOCC.CN(C)C=O.COC(=O)c1ccc(O)c(C=O)c1.ClCCl.O=C([O-])[O-].[K+].[K+]>>CCOc1ccc(C(=O)OC)cc1C=O",
        "output": "385"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cl[Sn](Cl)(Cl)Cl.O=C(Nc1ccc([N+](=O)[O-])cc1O)Nc1ccccc1I.O=C([O-])O.[Na+]>>Nc1ccc(NC(=O)Nc2ccccc2I)c(O)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCN4CCNCC4)cc3)ncc2c1=O.CS(=O)(=O)Cl.ClCCl>>CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCN4CCN(S(C)(=O)=O)CC4)cc3)ncc2c1=O",
        "output": "584"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCC1(c2ccc(Cl)cc2)CCCC1>>CS(=O)(=O)OCC1(c2ccc(Cl)cc2)CCCC1",
        "output": "0"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Nc1ccccc1N.O=C(O)C1(c2ccc(OCCCN3CCCC3)cc2)CCOCC1>>c1ccc2[nH]c(C3(c4ccc(OCCCN5CCCC5)cc4)CCOCC3)nc2c1",
        "output": "512"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)C=O.CNc1cc(-c2cccc(N)c2)nc(N)n1.O=C(O)C(O)c1ccccc1.Oc1cccc2[nH]nnc12>>CNc1cc(-c2cccc(NC(=O)C(O)c3ccccc3)c2)nc(N)n1",
        "output": "365"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCc1cc(C2CCNCC2)ccc1Nc1ncc(C(F)(F)F)c(CCc2ccccc2CC(N)=O)n1.CO.[Na+]>>CCc1cc(C2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(CCc2ccccc2CC(N)=O)n1",
        "output": "217"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CNC(CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CO1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cc(C(=O)O)cc2nc(NCc3cc(Cl)ccn3)oc12.F[P-](F)(F)(F)(F)F>>COc1cc(C(=O)N2CC(C)OCC2CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)cc2nc(NCc3cc(Cl)ccn3)oc12",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#Cc1ccc(-c2ccc(Cl)cc2)cn1.CC1CCN(Cc2cc(=O)c3cc(I)ccc3o2)CC1>>CC1CCN(Cc2cc(=O)c3cc(C#Cc4ccc(-c5ccc(Cl)cc5)cn4)ccc3o2)CC1",
        "output": "664"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccnc(C(=O)c2[nH]c3ccc(Cl)cc3c2CC(=O)O)c1.NCCO>>Cc1ccnc(C(=O)c2[nH]c3ccc(Cl)cc3c2CC(=O)NCCO)c1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.Fc1ccc(C2=CC3CCC(C2)N3)cc1.O=[Pt].[H][H]>>Fc1ccc(C2CC3CCC(C2)N3)cc1",
        "output": "806"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Nc1cccc(-c2c(Cc3ccccc3)cnc3c(C(F)(F)F)cccc23)c1.O=Cc1cc(F)ccc1F>>Fc1ccc(F)c(CNc2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)c1",
        "output": "359"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.Fc1cccc2[nH]ccc12.[H-].[Na+]>>Cn1ccc2c(F)cccc21",
        "output": "191"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCCC(COc1ccc(C(=O)OC)cc1)c1ccc2c(c1)SCCC2(C)C.CCO.Cl.O.[K+].[OH-]>>CCCCCC(COc1ccc(C(=O)O)cc1)c1ccc2c(c1)SCCC2(C)C",
        "output": "222"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br.Br.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F.O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1.c1ccc(CN2C[C@@H]3C[C@H]2CN3)cc1>>O=C(c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)N1C[C@@H]2C[C@H]1CN2Cc1ccccc1",
        "output": "605"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(-c3cccc(Cl)c3O)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12.N.O=C(O)C(F)(F)F>>Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cccc(Cl)c5O)c34)n(-c3ccccc3)c(=O)c12",
        "output": "897"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.COc1cncc(-c2nc(SC)[nH]c(=O)c2C#N)c1.O=P(Cl)(Cl)Cl>>COc1cncc(-c2nc(SC)nc(Cl)c2C#N)c1",
        "output": "14"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C1CCC(COCC2CC2)CC1.O=C1CO[C@H]2CCCC[C@@H]2N1C1CCNCC1>>O=C1CO[C@H]2CCCC[C@@H]2N1C1CCN(C2CCC(COCC3CC3)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CCN(C)S(=O)(=O)c1c(Cl)ccc(Nc2c(Cl)c(=O)c2=O)c1O.CN(C)C=O.Nc1ccccc1Cl.c1ccc(-c2ccccc2)cc1>>CCN(CC)CCN(C)S(=O)(=O)c1c(Cl)ccc(Nc2c(Nc3ccccc3Cl)c(=O)c2=O)c1O",
        "output": "510"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CNc1nc2c(cc1Br)C(C)CN(C(=O)C(F)(F)F)CC2.CO.O.O=C([O-])[O-].[K+].[K+]>>CNc1nc2c(cc1Br)C(C)CNCC2",
        "output": "703"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cl.N#Cc1ccc2nc(C3CCNCC3)[nH]c2c1.O=Cc1ccc(-c2nc3nccn3cc2-c2ccccc2)cc1>>N#Cc1ccc2nc(C3CCN(Cc4ccc(-c5nc6nccn6cc5-c5ccccc5)cc4)CC3)[nH]c2c1",
        "output": "567"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COc1cc(N2CC(N(C)C)C2)c([N+](=O)[O-])cc1Nc1nccc(-c2cnn3ccccc23)n1.O.[Cl-].[Fe].[NH4+]>>COc1cc(N2CC(N(C)C)C2)c(N)cc1Nc1nccc(-c2cnn3ccccc23)n1",
        "output": "202"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.NC1CC1.O=S1(=O)N(CCCCBr)Cc2ccccc2N1c1ccccc1F>>O=S1(=O)N(CCCCNC2CC2)Cc2ccccc2N1c1ccccc1F",
        "output": "147"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CS(=O)(=O)Cc1cccc(Nc2ncnc(-c3ccc(F)cc3F)n2)c1.OCc1cc(F)cc(F)c1F>>CS(=O)(=O)Cc1cccc(Nc2ncnc(-c3ccc(F)cc3OCc3cc(F)cc(F)c3F)n2)c1",
        "output": "485"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.O=C(Cl)c1ccccc1.O=C(Nc1ccccc1Oc1ccc(Cl)cc1Cl)C1CCNCC1.c1ccncc1>>O=C(Nc1ccccc1Oc1ccc(Cl)cc1Cl)C1CCN(C(=O)c2ccccc2)CC1",
        "output": "201"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NC1(c2ccc(-c3oc4nc(S(C)(=O)=O)nc(C(F)(F)F)c4c3-c3ccccc3)cc2)CCC1.NCCO>>CC(C)(C)OC(=O)NC1(c2ccc(-c3oc4nc(NCCO)nc(C(F)(F)F)c4c3-c3ccccc3)cc2)CCC1",
        "output": "629"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.COc1ccc(CN(c2nc(Cl)nn3c(C#N)cnc23)C2CC2)cc1.N#Cc1cc(N)c(Cl)c(N2CCN3C(CCS3(=O)=O)C2)c1.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].[Pd+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1ccc(CN(c2nc(Nc3cc(C#N)cc(N4CCN5C(CCS5(=O)=O)C4)c3Cl)nn3c(C#N)cnc23)C2CC2)cc1",
        "output": "990"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Cc1onc(-c2ccc(F)cc2)c1CO.N#Cc1ccc(Cl)nc1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[H-].[Na+]>>Cc1onc(-c2ccc(F)cc2)c1COc1ccc(C#N)cn1",
        "output": "433"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)O)c(OC)cc3C)cc12.Cl.ClCCl.NC1(c2cnccn2)CC1.O.On1nnc2ccccc21>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5cnccn5)CC4)c(OC)cc3C)cc12",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cl.O=C(NC(Cc1ccc(C(F)(F)F)cc1)C(=O)c1ccc(F)cc1)c1cc(=O)cco1.[BH4-].[Cl-].[Cl-].[Mn+2].[Na+]>>O=C(NC(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(F)cc1)c1cc(=O)cco1",
        "output": "24"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CN.COc1cc(CBr)ccc1-c1nnc(-c2nc(Br)cnc2N)o1.O.O=C([O-])[O-].[Na+].[Na+]>>CNCc1ccc(-c2nnc(-c3nc(Br)cnc3N)o2)c(OC)c1",
        "output": "446"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(=O)Nc1cccc(C#N)c1.CCCCC(=O)Cl.N#Cc1cc(N)cc(Cl)c1>>CCCCC(=O)Nc1cc(Cl)cc(C#N)c1",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.CO.Cl[Pd]Cl.O=S(=O)(c1ccccc1)c1ccc(Br)cc1.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc(S(=O)(=O)c3ccccc3)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cc1cc(C(=O)O)c(O)cc1Br.ClCCl.O.O=S(Cl)Cl>>COC(=O)c1cc(C)c(Br)cc1O",
        "output": "195"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.ClCCCl.ClCCl.NC(=O)c1ccc(Oc2ccc(C=O)cc2)nc1.[Na+].c1ccc(C2(c3ccccc3)CCNCC2)cc1>>NC(=O)c1ccc(Oc2ccc(CN3CCC(c4ccccc4)(c4ccccc4)CC3)cc2)nc1",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)Cc1c(F)cc2ncc(N3CCOCC3)cc2c1F.NN.O>>NNC(=O)Cc1c(F)cc2ncc(N3CCOCC3)cc2c1F",
        "output": "130"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.COc1cc2c(cc1O)CCCC2=O.ClCCCBr.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(cc1OCCCCl)CCCC2=O",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1cc(O)ccc1C=O.N#Cc1ccc(Cl)cc1F.O.O=C([O-])[O-].[Cs+].[Cs+]>>COc1cc(Oc2cc(Cl)ccc2C#N)ccc1C=O",
        "output": "564"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.Nc1ccc(O)cc1C(=O)O.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1ccc(N)c(C(=O)O)c1",
        "output": "746"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.N#Cc1ccc(CBr)cc1.O.[H-].[Na+].c1cc(N2CCNCC2)ccn1>>N#Cc1ccc(CN2CCN(c3ccncc3)CC2)cc1",
        "output": "248"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCOCC.CCOc1ccc(C(=O)c2cc(Br)ccc2Cl)c(F)c1F.FB(F)F.O=C([O-])O.[Na+]>>CCOc1ccc(Cc2cc(Br)ccc2Cl)c(F)c1F",
        "output": "181"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1ccccc1.C1CCOC1.CC(C)(N)CO.[Na+].[OH-]>>CC(C)(N)COCc1ccccc1",
        "output": "464"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1ccc(F)cc1-c1cc(N)c(N(CC(C)C)C2CCC(F)(F)CC2)cc1F.Cc1ccc(N=C=O)cc1>>COC(=O)c1ccc(F)cc1-c1cc(NC(=O)Nc2ccc(C)cc2)c(N(CC(C)C)C2CCC(F)(F)CC2)cc1F",
        "output": "473"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(Nc2cc3ccccc3c(Cl)n2)n[nH]1.OB(O)c1ccc(F)c(F)c1>>Cc1cc(Nc2cc3ccccc3c(-c3ccc(F)c(F)c3)n2)n[nH]1",
        "output": "865"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1noc2c1CNCC2.Cc1ccccc1.O=C=Nc1ccc(Cl)c(Cl)c1>>CCOC(=O)c1noc2c1CN(C(=O)Nc1ccc(Cl)c(Cl)c1)CC2",
        "output": "323"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCO.CCOC(C)=O.COc1cc(C(=O)C(C(=O)c2cccc(S(=O)(=O)NC(=N)C(C)(C)O)c2)=C2Nc3ccccc3N2)ccn1.Cl>>CC(C)(O)C(=N)NS(=O)(=O)c1cccc(C(=O)C(C(=O)c2cc[nH]c(=O)c2)=C2Nc3ccccc3N2)c1",
        "output": "758"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.Nc1ccc(O)c(Cl)c1.O>>CC(=O)Nc1ccc(O)c(Cl)c1",
        "output": "6"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cc2cc(N)ccc2[nH]1.Cn1c(-c2cc3nccc(Cl)c3s2)cnc1C(=O)NCc1ccncc1>>Cc1cc2cc(Nc3ccnc4cc(-c5cnc(C(=O)NCc6ccncc6)n5C)sc34)ccc2[nH]1",
        "output": "927"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)C(C)(C)c1ccc(Br)cc1.CS(C)=O.Cl[Pd]Cl.O.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COC(=O)C(C)(C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1",
        "output": "942"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CS(C)=O.Cc1nc2n(c(=O)c1CCO)CCCC2.ClCCl.O.O=C(Cl)C(=O)Cl>>Cc1nc2n(c(=O)c1CC=O)CCCC2",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.C[C@@H](O)CCCCO.ClCCl.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>C[C@@H](O)CCCCOC(=O)c1ccc([N+](=O)[O-])cc1",
        "output": "51"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(Cl)c(Cl)c2)[C@H](CO)C1.CCN(CC)CC.CS(=O)(=O)Cl.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N1CCO[C@@H](c2ccc(Cl)c(Cl)c2)[C@H](COS(C)(=O)=O)C1",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN([C@@H]1CCCc2c(OCC(=O)OC(C)(C)C)cccc21)S(=O)(=O)c1cc(F)cc(C(F)(F)F)c1.[Na+].[OH-]>>CN([C@@H]1CCCc2c(OCC(=O)O)cccc21)S(=O)(=O)c1cc(F)cc(C(F)(F)F)c1",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)C(Cc1ccc(OC)c(OC)c1)NC(=O)CC(c1ccccc1)c1ccccc1.[Na+].[OH-]>>COc1ccc(CC(NC(=O)CC(c2ccccc2)c2ccccc2)C(=O)O)cc1OC",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)CC(c1cccc(COc2cnc(OC)c(CC(C)(C)C)c2)c1)C1CC1.CN(C)C=O.Cl.[Cl-].c1cc[nH+]cc1>>CCOC(=O)CC(c1cccc(COc2cnc(O)c(CC(C)(C)C)c2)c1)C1CC1",
        "output": "408"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC1(C)OB(c2ccc3ncccc3c2)OC1(C)C.CCOC(C)=O.Nc1cc(Br)cnc1Cl.O.O=C([O-])[O-].[K+].[K+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Nc1cc(-c2ccc3ncccc3c2)cnc1Cl",
        "output": "938"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)[Si](OS(=O)(=O)C(F)(F)F)(C(C)C)C(C)C.CCN(CC)CC.CN(C)C=O.CO.ClCCl.N.O[C@@H]1CCN(c2nnc3ccc(F)cn23)C1>>CC(C)[Si](O[C@@H]1CCN(c2nnc3ccc(F)cn23)C1)(C(C)C)C(C)C",
        "output": "839"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)C(C)C.CC(=O)N1CCNCC1.ClCCCl.O=C([O-])[O-].[I-].[K+].[Na+].[Na+]>>CC(=O)N1CCN(CCCl)CC1",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CP(C)C.Cc1csc2nc(C(C)N=[N+]=[N-])c(-c3cccc(F)c3F)c(=O)n12>>Cc1csc2nc(C(C)N)c(-c3cccc(F)c3F)c(=O)n12",
        "output": "89"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COc1cc(CCC(=O)O)cc(OC)c1>>COc1cc(CCCO)cc(OC)c1",
        "output": "231"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)N1CCC(Oc2ccc3sc(C(=O)O)cc3c2)CC1.CCN(C(C)C)C(C)C.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cl.FC1(F)CCNCC1.F[P-](F)(F)(F)(F)F>>CC(C)N1CCC(Oc2ccc3sc(C(=O)N4CCC(F)(F)CC4)cc3c2)CC1",
        "output": "857"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=C(N[C@@H](CSc1ccccc1[N+](=O)[O-])C(=O)O)OCc1ccccc1.[Cl-].[NH4+].[Zn]>>Nc1ccccc1SC[C@H](NC(=O)OCc1ccccc1)C(=O)O",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1cc2cc(C(=O)OC(C)C)ccc2[nH]1.CO.[Li+].[OH-]>>CC(C)OC(=O)c1ccc2[nH]c(C(=O)O)cc2c1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.ClCCl.O=S(Cl)Cl.O=[N+]([O-])c1ccccc1-c1nc2cc(CO)cnc2s1>>O=[N+]([O-])c1ccccc1-c1nc2cc(CCl)cnc2s1",
        "output": "477"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COCCN(c1ccccc1)c1nc(N)nc(-c2noc(-c3ccc(C(=O)OC)nc3)n2)n1.[BH4-].[Na+]>>COCCN(c1ccccc1)c1nc(N)nc(-c2noc(-c3ccc(CO)nc3)n2)n1",
        "output": "546"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)c1ccc(Cn2ccc3cc(N)ccc32)cc1.CCCCCC.CCN(C(C)C)C(C)C.CCOC(C)=O.ClCCl.O=S(=O)(Cl)c1ccccc1>>CC(C)(C)c1ccc(Cn2ccc3cc(NS(=O)(=O)c4ccccc4)ccc32)cc1",
        "output": "68"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.CCc1ccc(B(O)O)cc1.ClC(Cl)Cl.Oc1cccc(Br)c1.[Cu+2].c1ccncc1>>CCc1ccc(Oc2cccc(Br)c2)cc1",
        "output": "920"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCc1cc(NC(=O)C2CCc3ccc(Oc4ccnc(CO)c4)cc3C2)cc(C(F)(F)F)c1.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)NCc1cc(NC(=O)C2CCc3ccc(Oc4ccnc(C=O)c4)cc3C2)cc(C(F)(F)F)c1",
        "output": "263"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)C(c1ccc(Cn2cc(C(F)(F)F)ccc2=O)cc1)C1CCCC1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)C(c1ccc(Cn2cc(C(F)(F)F)ccc2=O)cc1)C1CCCC1",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Cc1oc(-c2ccccc2)nc1CCl.Cl.O.O=C1NC(=O)C(CCc2ccc(O)cc2)S1.[H-].[Na+]>>Cc1oc(-c2ccccc2)nc1COc1ccc(CCC2SC(=O)NC2=O)cc1",
        "output": "760"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.ClCCl.O=C(O)c1ccc(F)cc1.O[C@@H]1CCCNC1.On1nnc2ccccc21>>O=C(c1ccc(F)cc1)N1CCC[C@@H](O)C1",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)[O-].CCOC(C)=O.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.Cn1c(=O)c2c(nc(N3CCN(C(=O)OC(C)(C)C)CC3)n2-c2ccccc2C=O)n(C)c1=O.O.[Br-].[K+]>>C=Cc1ccccc1-n1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2c1c(=O)n(C)c(=O)n2C",
        "output": "649"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.C[Si](C)(C)c1ccc([N+](=O)[O-])cc1F.[C].[Pd]>>C[Si](C)(C)c1ccc(N)cc1F",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1ccc([C@H](C)N)cc1.Cl.O=C(O)c1cc(Cl)cnc1OCc1ccc(Cl)cc1>>COC(=O)c1ccc([C@H](C)NC(=O)c2cc(Cl)cnc2OCc2ccc(Cl)cc2)cc1",
        "output": "790"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.CN(C)c1ccncc1.COC(=O)c1cc(C(=O)O)nn1-c1ncccc1Cl.Cl.ClCCl.Nc1ccc(C(F)(F)F)cc1>>COC(=O)c1cc(C(=O)Nc2ccc(C(F)(F)F)cc2)nn1-c1ncccc1Cl",
        "output": "844"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNS(=O)(=O)Cc1cc(Br)c(N)c(Br)c1.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CNS(=O)(=O)Cc1cc(Br)c(NC(=O)C(F)(F)F)c(Br)c1",
        "output": "106"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.COc1ccc(C)c(NC(C)=O)c1.O=S(=O)(O)O.O=[N+]([O-])O>>COc1cc(NC(C)=O)c(C)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(=O)[O-].C[N+](=O)[O-].O=Cc1ccc(Cl)c(OCc2ccccc2)c1.[NH4+]>>O=[N+]([O-])C=Cc1ccc(Cl)c(OCc2ccccc2)c1",
        "output": "282"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCNC(=O)C(F)(F)F.CCCC(CCC)CSc1cccc(Br)c1>>CCCC(CCC)CSc1cccc(C#CCNC(=O)C(F)(F)F)c1",
        "output": "659"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.CN(C)c1ccncc1.Cc1cc(OCCC(C)(C)O)ccc1-c1cccc(C=O)c1.ClC(Cl)Cl.[Cl-].[NH4+].c1ccncc1>>CC(=O)OC(C)(C)CCOc1ccc(-c2cccc(C=O)c2)c(C)c1",
        "output": "254"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.N#Cc1cccc(C(=O)Nc2c(Cl)cncc2Cl)c1.O.O=C(OO)c1cccc(Cl)c1>>N#Cc1cccc(C(=O)Nc2c(Cl)c[n+]([O-])cc2Cl)c1",
        "output": "262"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Nc1ccccn1.O=C(O)C1(c2ccc3c(c2)OCO3)CC1.O=S(Cl)Cl.c1ccncc1>>O=C(Nc1ccccn1)C1(c2ccc3c(c2)OCO3)CC1",
        "output": "368"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(N)cc1-c1c(Br)cnn1C(C)C.ClCCl.O=C=Nc1ccc(Cl)cc1>>COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Br)cnn1C(C)C",
        "output": "804"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.CCCn1c(COC)nc2c(N)nc3ccc(O)cc3c21.CN1CCCC(CCl)C1.Cl.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CCCn1c(COC)nc2c(N)nc3ccc(OCC4CCCN(C)C4)cc3c21",
        "output": "74"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C.CCOC(C)=O.O=C(Cl)c1ccccc1.O=C([O-])O.[Na+].c1ccncc1>>CC(=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC(=O)c5ccccc5)CC[C@]4(C)[C@H]3CC[C@]12C",
        "output": "51"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)C(CCC(=O)O)NC(=O)OCc1ccccc1.CC(C)COC(=O)Cl.CCN(CC)CC>>CC(C)(C)OC(=O)C(CCCO)NC(=O)OCc1ccccc1",
        "output": "231"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cc(Cl)ccc1N.Cc1cc(Cl)ccc1NC=O.Cc1cccc(Cl)c1N.Cc1cccc(N)c1C=O.Cl.Cl>>Cc1ccccc1NC=O",
        "output": "253"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cc1ccc(OCCO)cc1.Cc1nc(C(O)CN)cs1>>Cc1nc(C(O)CNC(C)Cc2ccc(OCCO)cc2)cs1",
        "output": "236"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.O=C(Cl)c1ccc(F)c(F)c1.Oc1cccc(-c2nc(N3CCOCC3)c3nnn(CCN4CCNCC4)c3n2)c1>>O=C(c1ccc(F)c(F)c1)N1CCN(CCn2nnc3c(N4CCOCC4)nc(-c4cccc(O)c4)nc32)CC1",
        "output": "201"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#C[Si](C)(C)C.CCN(CC)CC.Cl.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=C(C(=O)c1ccc(Oc2ccc(Br)cc2)cc1)c1ccccc1>>C[Si](C)(C)C#Cc1ccc(Oc2ccc(C(=O)C(=O)c3ccccc3)cc2)cc1",
        "output": "671"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CCOC(C)=O.CO.COc1ccc(C(C#Cc2ccccc2)CN)cc1OC1CCCC1>>COc1ccc(C(C#Cc2ccccc2)CNC(C)=O)cc1OC1CCCC1",
        "output": "339"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CS(=O)(=O)c1ccc(O)cc1.Cc1cc(CCl)c2ccccc2n1.Cl.O.[Na+].[OH-]>>Cc1cc(COc2ccc(S(C)(=O)=O)cc2)c2ccccc2n1",
        "output": "49"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1cnc(C(=O)c2cccc(OCC(=O)O)c2)c2cc(OC)c(OC)cc12.CO.[Li+].[OH-]>>COc1cc2c(C(=O)O)cnc(C(=O)c3cccc(OCC(=O)O)c3)c2cc1OC",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1ccc(CCNCC(O)c2csc(NC(=O)c3ccccc3)n2)cc1.[Na+].[OH-]>>O=C(O)c1ccc(CCNCC(O)c2csc(NC(=O)c3ccccc3)n2)cc1",
        "output": "5"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(Cn2ccc3cc(SC4CCN(C(=O)OC(C)(C)C)CC4)c(Cl)cc3c2=O)cc1.ClCCl.O=C(OO)c1cccc(Cl)c1>>COc1ccc(Cn2ccc3cc(S(=O)C4CCN(C(=O)OC(C)(C)C)CC4)c(Cl)cc3c2=O)cc1",
        "output": "500"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)CC(=O)Cl.CCN(CC)CC.CCOCC.COc1cc(C)cc(OC)c1N.O>>COc1cc(C)cc(OC)c1NC(=O)CC(C)C",
        "output": "9"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(CN2C[C@@]3(CCC[C@H](Cn4cnc5ccc(C#N)cc54)C3)OC2=O)CCN(C(=O)OC(C)(C)C)C1.Cl>>CC1(CN2C[C@@]3(CCC[C@H](Cn4cnc5ccc(C#N)cc54)C3)OC2=O)CCNC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc2c(cc1C(C)=O)C(C)CCO2.ClB(Cl)Cl.ClCCl>>CC(=O)c1cc2c(cc1O)OCCC2C",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc(-c2nc3ccc(O)cc3n2Cc2ccccc2C(F)(F)F)cc(OC)c1OC.ClCCCN1CCCCC1>>COc1cc(-c2nc3ccc(OCCCN4CCCCC4)cc3n2Cc2ccccc2C(F)(F)F)cc(OC)c1OC",
        "output": "74"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Fc1cccc(CBr)c1.O=c1ccc(Br)c[nH]1>>O=c1ccc(Br)cn1Cc1cccc(F)c1",
        "output": "528"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.Cc1cc(C#N)ncc1-c1cc(S(=O)(=O)N2CCCCc3ccccc32)c(O)cc1Cl.O=C([O-])[O-].OCCCBr.[Cs+].[Cs+]>>Cc1cc(C#N)ncc1-c1cc(S(=O)(=O)N2CCCCc3ccccc32)c(OCCCO)cc1Cl",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COCC1CCCN(c2nc3cc(C(=O)OC)ccc3nc2-c2ccc(F)cc2)C1.O.[Na+].[OH-]>>COCC1CCCN(c2nc3cc(C(=O)O)ccc3nc2-c2ccc(F)cc2)C1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.COC[C@H](O)COc1nn(-c2ccccc2)c(N)c1C.O.c1c[nH]cn1>>COC[C@@H](COc1nn(-c2ccccc2)c(N)c1C)O[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CCOC(=O)Cl.CN1CCOCC1.CO.O.O=C(O)c1ccc(N2CCOCC2)cc1.[BH4-].[Na+]>>OCc1ccc(N2CCOCC2)cc1",
        "output": "72"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.Cn1c(Cl)nc(-c2ccncc2)c(NC(=O)c2ccccc2)c1=O.NC[C@@H](N)Cc1ccccc1>>Cn1c(NC[C@@H](N)Cc2ccccc2)nc(-c2ccncc2)c(NC(=O)c2ccccc2)c1=O",
        "output": "544"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1nn(-c2ccc(CCNC(=O)Oc3ccccc3)cc2)c(C)c1-c1ccccc1.NS(=O)(=O)c1ccccc1O>>Cc1nn(-c2ccc(CCNC(=O)NS(=O)(=O)c3ccccc3O)cc2)c(C)c1-c1ccccc1",
        "output": "690"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCC[C@H](C(=O)O)C1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CNC.Cl.ClCCl>>CN(C)C(=O)[C@H]1CCC[C@H](NC(=O)OC(C)(C)C)C1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CS(=O)(=O)NCCNc1c([N+](=O)[O-])cnc2cc(Br)ccc12.[Pt]>>CS(=O)(=O)NCCNc1c(N)cnc2cc(Br)ccc12",
        "output": "269"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cc([N+](=O)[O-])ccc1S(=O)(=O)Cl.ClCCl.Nc1ccccc1NS(=O)(=O)c1cc2ccccc2s1.c1ccncc1>>COc1cc([N+](=O)[O-])ccc1S(=O)(=O)Nc1ccccc1NS(=O)(=O)c1cc2ccccc2s1",
        "output": "68"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)C1(O)CCOc2ccc(C)cc21.O.O.[Li]O>>Cc1ccc2c(c1)C(O)(C(=O)O)CCO2",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCO.COC(=O)c1cccc(S(N)(=O)=O)c1.[BH4-].[Ca+2].[Cl-].[Cl-].[Na+]>>NS(=O)(=O)c1cccc(CO)c1",
        "output": "444"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)CN1C(=O)CCC1C(=O)N1CCN(c2ccccc2C(C)(C)C)CC1.Cl.[Li+].[OH-]>>CC(C)(C)c1ccccc1N1CCN(C(=O)C2CCC(=O)N2CC(=O)O)CC1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.C1CCOC1.COc1ccc(S(=O)(=O)N2CCCCC(C(=O)O)C2C(=O)OC(C)(C)C)cc1>>COc1ccc(S(=O)(=O)N2CCCCC(CO)C2C(=O)OC(C)(C)C)cc1",
        "output": "231"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNCC1.CCO.Cc1[nH]c(C=O)c(CCC(=O)O)c1S(C)(=O)=O.O=C1Cc2ccc(Br)cc2N1>>Cc1[nH]c(/C=C2\\C(=O)Nc3cc(Br)ccc32)c(CCC(=O)O)c1S(C)(=O)=O",
        "output": "911"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)N.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.O.O=C(O)[C@@H]1CCCN1C(=O)OCc1ccccc1>>CC(C)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1",
        "output": "216"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.CN1CCC(c2c[nH]c3ccc(N)cc23)CC1.O=C(Cl)c1ccc2ccccc2c1.[Na+].[OH-]>>CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc5ccccc5c4)cc23)CC1",
        "output": "11"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O=C(c1ccccc1)N1CCN(c2ccc([N+](=O)[O-])c(Nc3ccccc3)c2)CC1.[Pd]>>Nc1ccc(N2CCN(C(=O)c3ccccc3)CC2)cc1Nc1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N#Cc1ccccc1-c1ccc(C(=O)O)c(NCCc2cccc(F)c2)n1.NCc1cccnc1.On1nnc2ccccc21>>N#Cc1ccccc1-c1ccc(C(=O)NCc2cccnc2)c(NCCc2cccc(F)c2)n1",
        "output": "674"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C1c2ccccc2C(=O)N1Cc1n[nH]c2ccc([N+](=O)[O-])cc12.[Pd]>>Nc1ccc2[nH]nc(CN3C(=O)c4ccccc4C3=O)c2c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCCCCCCCCCCC(=O)Cl.CN(CCO)C(=O)c1ccccc1>>CCCCCCCCCCCCCCCC(=O)OCCN(C)C(=O)c1ccccc1",
        "output": "126"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)N[C@@H](CCCN1CCCCC1)C(=O)O.ClCCl.NCc1ccccc1.O.On1nnc2ccccc21>>CC(C)(C)OC(=O)N[C@@H](CCCN1CCCCC1)C(=O)NCc1ccccc1",
        "output": "599"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN(C)C=O.COc1cccc(C(=CCN2CCNCC2)C2(O)CCCCC2)c1.COc1cccc(CCl)c1.O=C([O-])[O-].[Cs+].[Cs+]>>COc1cccc(CN2CCN(CC=C(c3cccc(OC)c3)C3(O)CCCCC3)CC2)c1",
        "output": "156"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOc1ccccc1C(=O)O.COc1ccnc(N2CC3CNCC3C2)n1>>CCOc1ccccc1C(=O)N1CC2CN(c3nccc(OC)n3)CC2C1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N(Cc1cccc(C(F)(F)F)c1)c1ccnc(-c2cc(N3CCCCC3)ccc2[N+](=O)[O-])c1.ClCCl.[Zn]>>CC(C)(C)OC(=O)N(Cc1cccc(C(F)(F)F)c1)c1ccnc(-c2cc(N3CCCCC3)ccc2N)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#C[Si](C)(C)C.CCN(CC)CC.Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(Br)cc2)c(C)c1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(C#C[Si](C)(C)C)cc2)c(C)c1",
        "output": "671"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(F)(F)C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCCC1=O.COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(Cl)cc3)c2)[C@H](C)N)c1.F[P-](F)(F)(F)(F)F.O>>COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(Cl)cc3)c2)[C@H](C)NC(=O)C(C)(F)F)c1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.COc1cc(C(=O)O)cc(Cl)n1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cc(Cl)nc(OC)c1",
        "output": "415"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)CN.CCN(C(C)C)C(C)C.CN(C)C=O.Clc1cc(-c2cccnc2)nc(-c2cnc3ccccn23)n1>>CC(C)(C)CNc1cc(-c2cccnc2)nc(-c2cnc3ccccn23)n1",
        "output": "166"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C=Cc1ccc(Oc2ccccc2)cc1.[Na+].[OH-]>>O=C(C=Cc1ccc(Oc2ccccc2)cc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CNC.Cl.O=C(O)c1ccc([N+](=O)[O-])cc1F.On1nnc2ccccc21>>CN(C)C(=O)c1ccc([N+](=O)[O-])cc1F",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@H]1CN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CCN1.Cc1ccc(C(=O)O)c(C)n1.F[P-](F)(F)(F)(F)F>>Cc1ccc(C(=O)N2CCN(S(=O)(=O)c3ccc(C(F)(F)F)cc3)C[C@@H]2C)c(C)n1",
        "output": "256"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCI.CCOc1cc2c(N3CCC(n4c(=O)c5cc(C)ccc5n(C)c4=O)CC3)nc(N3CCOCC3)nc2cc1O>>CCCCOc1cc2nc(N3CCOCC3)nc(N3CCC(n4c(=O)c5cc(C)ccc5n(C)c4=O)CC3)c2cc1OCC",
        "output": "198"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CSc1nc(O)c(C)c(-c2ccc(F)cc2F)n1.O=P(Cl)(Cl)Cl>>CSc1nc(Cl)c(C)c(-c2ccc(F)cc2F)n1",
        "output": "168"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.O=[N+]([O-])c1cc(CO)ccc1F>>O=Cc1ccc(F)c([N+](=O)[O-])c1",
        "output": "179"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(N2CCNC2=O)c1.ClCCl.O=C(O)C(F)(F)F>>Nc1cccc(N2CCNC2=O)c1",
        "output": "782"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.Cc1cc(Cl)ncc1Nc1ncnc(OC2CCN(C(=O)OC(C)C)CC2)c1C>>Cc1cc(N2CCOCC2)ncc1Nc1ncnc(OC2CCN(C(=O)OC(C)C)CC2)c1C",
        "output": "220"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC(=O)Cl.CCN(CC)CC.ClCCl.NCc1ccc(C2=NOC(c3cc(Br)cc(C(F)(F)F)c3)(C(F)(F)F)C2)cc1Cl.O>>CCCC(=O)NCc1ccc(C2=NOC(c3cc(Br)cc(C(F)(F)F)c3)(C(F)(F)F)C2)cc1Cl",
        "output": "206"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(C)n1c(=O)cc(Cl)[nH]c1=O.CCCCCC.C[C@H](N)c1ccccc1>>CC(C)n1c(=O)cc(N[C@@H](C)c2ccccc2)[nH]c1=O",
        "output": "165"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCCCC(=O)O.CC(C)N1CCNCC1.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl>>C#CCCCC(=O)N1CCN(C(C)C)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCCCCc1ccccc1.O=C1C(=O)c2ccccc2C2=C1SCC1(CCNCC1)O2>>O=C1C(=O)c2ccccc2C2=C1SCC1(CCN(CCCCc3ccccc3)CC1)O2",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C(=O)OC(C)(C)C)[C@H](Cc1ccc2ccccc2c1)C(=O)O.CN(C)C=O.CNCCc1ccccc1NS(C)(=O)=O.Cl.ClCCl.On1nnc2cccnc21>>CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)OC(C)(C)C",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)OCCCCCCCl.CC(C)=O.ClCCl.[I-].[Na+]>>CC(C)(C)[Si](C)(C)OCCCCCCI",
        "output": "97"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1cccc(OCC(=O)OCC)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1cccc(OCCO)c1",
        "output": "225"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(CO)c(N)c1.ClCCl.O=[Mn]=O>>COc1ccc(C=O)c(N)c1",
        "output": "179"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C#N)CC=O.CC(C)(C)OC(=O)N1CCC(NCc2ccc(Cl)cc2Cl)CC1.[Na+]>>CC(C)(C#N)CCN(Cc1ccc(Cl)cc1Cl)C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "858"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)c1ccncc1.COCOc1ccc(CO)c2cccc(C)c12.O.c1c[nH]cn1>>COCOc1ccc(CO[Si](C)(C)C(C)(C)C)c2cccc(C)c12",
        "output": "193"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccccc1.Nc1ccc2ncccc2c1.O=C(Nn1ccc2ccccc21)Oc1ccccc1>>O=C(Nc1ccc2ncccc2c1)Nn1ccc2ccccc21",
        "output": "948"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.Cl.Clc1cccc(N2CCNCC2)c1Cl.O.O=C1CCc2ccc(OCCCCBr)cc2N1>>O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.C1CCOC1.Cn1nc(N2c3ccccc3C[C@H]2C(=O)O)ccc1=O.O.O=C(n1ccnc1)n1ccnc1>>Cn1nc(N2c3ccccc3C[C@H]2C(=O)N2CCCCC2)ccc1=O",
        "output": "685"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)c1csc(CCc2ccn3c(=O)c(/C=C/C(=O)OC(C)(C)C)c(N4CCOCC4)nc3c2)n1.O=CO>>CC(C)c1csc(CCc2ccn3c(=O)c(/C=C/C(=O)O)c(N4CCOCC4)nc3c2)n1",
        "output": "158"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cccc2c1NC(=O)CC2.O=C(Cl)CCl>>COc1ccc(C(=O)CCl)c2c1NC(=O)CC2",
        "output": "31"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(S)CCO.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCN(C(C)C)C(C)C.Cc1c(-c2ccc(Br)cc2)nc2n1CCc1ccccc1C2OC1CCN(C)CC1.N.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd]>>Cc1c(-c2ccc(SC(C)(C)CCO)cc2)nc2n1CCc1ccccc1C2OC1CCN(C)CC1",
        "output": "824"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CN.CN(C)C=O.COc1cc(C(=O)O)ccc1[N+](=O)[O-].ClCCCl.On1nnc2ccccc21>>CNC(=O)c1ccc([N+](=O)[O-])c(OC)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(O)c1c(F)c(NC(=O)C(C)(C)C)c2c(=O)cc(-c3ccc(NC(=O)C(C)(C)C)c(F)c3)oc2c1F.Cc1ccccc1.[Mn+4].[O-2].[O-2]>>CC(=O)c1c(F)c(NC(=O)C(C)(C)C)c2c(=O)cc(-c3ccc(NC(=O)C(C)(C)C)c(F)c3)oc2c1F",
        "output": "32"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1c1ccc(Cl)cc1.COC(=O)[C@@H]1CN(CCF)CC[C@H]1c1ccc(Cl)cc1>>OC[C@@H]1CN(CCF)CC[C@H]1c1ccc(Cl)cc1",
        "output": "343"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COC(=O)C(C)c1ccsc1.O.[K+].[OH-]>>CC(C(=O)O)c1ccsc1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCc1cc(C(=O)c2ccccc2Cl)c(-n2c(C)nnc2CN)s1.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cc1c(C(=O)O)[nH]c2ccccc12.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccc(S(=O)(=O)O)cc1.F[P-](F)(F)(F)(F)F.O>>CCc1cc(C(=O)c2ccccc2Cl)c(-n2c(C)nnc2CNC(=O)c2[nH]c3ccccc3c2C)s1",
        "output": "137"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCC(C(=O)OC)c1c(C)nc(/C=C/c2ccccc2)nc1-c1ccccc1.CCO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc(/C=C/c2ccccc2)nc1-c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(CN3CCN(C(=O)OCc4ccccc4)CC3)cc2)n1.CCO.[H][H].[Pd]>>CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(CN3CCNCC3)cc2)n1",
        "output": "428"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN=C=NCCCN(C)C.CCO.CN(C)C=O.Cl.Cn1c(=O)c2c(nc(N3CCC[C@@H](NC(=O)OC(C)(C)C)C3)n2Cc2ccccc2Cl)c2ccc(C(=O)O)cc21.On1nnc2ccccc21.[Cl-].[NH4+]>>CCOC(=O)c1ccc2c3nc(N4CCC[C@@H](NC(=O)OC(C)(C)C)C4)n(Cc4ccccc4Cl)c3c(=O)n(C)c2c1",
        "output": "47"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(C#Cc2ccc(F)cc2)cc1[N+](=O)[O-].Cl[Sn]Cl.O.O>>CC(C)(C)OC(=O)Nc1ccc(C#Cc2ccc(F)cc2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>O=c1c(CBr)cn(-c2ccccc2)c2cc(Cl)ccc12",
        "output": "625"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCC2=NCCCN2CC1.C1CCOC1.CCCCCS(N)(=O)=O.COCCOc1ccc(C(C)CC(=O)O)c(Oc2ncc(C(F)(F)F)cc2Cl)c1>>CCCCCS(=O)(=O)NC(=O)CC(C)c1ccc(OCCOC)cc1Oc1ncc(C(F)(F)F)cc1Cl",
        "output": "644"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCBr.CO.Cc1nc(I)c(I)[nH]1.ClCCl>>Cc1nc(I)c(I)n1CCNC(=O)OC(C)(C)C",
        "output": "276"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=C(C)C(=O)O.CCCCO.Cc1ccc(S(=O)(=O)O)cc1>>C=C(C)C(=O)OCCCC",
        "output": "174"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NC1CCC(C(=O)Nc2ccc(C(N)=O)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>NC(=O)c1ccc(NC(=O)C2CCC(N)CC2)cc1",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NCCc1ccccc1F.O=CC1CC1>>Fc1ccccc1CCNCC1CC1",
        "output": "426"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CNCCN1c2ccccc2COc2ccccc21.COc1cccc(CCOS(C)(=O)=O)c1.O=C([O-])[O-].[I-].[Na+].[Na+].[Na+]>>COc1cccc(CCN(C)CCN2c3ccccc3COc3ccccc32)c1",
        "output": "496"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)CCc1ccc(SCc2coc(/C=C/c3ccccc3)n2)cc1.Cl.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCc1ccc(SCc2coc(/C=C/c3ccccc3)n2)cc1",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ncc(-c2ccc3c(c2)CCNC3C)c(OC)n1.O=C(O)c1cc2ncc(Br)cn2n1>>COc1ncc(-c2ccc3c(c2)CCN(C(=O)c2cc4ncc(Br)cn4n2)C3C)c(OC)n1",
        "output": "952"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Nc1cc(F)c(C=O)cc1[N+](=O)[O-].CC(C)(C)O.CC=C(C)C.O.[Na+].[O-][Cl+][O-]>>CC(=O)Nc1cc(F)c(C(=O)O)cc1[N+](=O)[O-]",
        "output": "384"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CN(c1ccccc1)c1ccc(Cl)cc1[N+](=O)[O-].Cl[Sn]Cl.O.O>>CN(c1ccccc1)c1ccc(Cl)cc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(CCn2cnc(-c3cc4nccc(Cl)c4s3)c2)CC1.CC(C)(C)[O-].CN1CCCC1=O.Cl.Nc1ccc(O)c(F)c1.Nc1ccc(O)c(F)c1.[K+].[O-]c1ccccc1>>CC(C)(C)OC(=O)N1CCN(CCn2cnc(-c3cc4nccc(Oc5ccc(N)cc5F)c4s3)c2)CC1",
        "output": "936"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COC(=O)c1sc(-c2ccc(OC(F)(F)F)cc2)cc1N.Cl.[Li+].[OH-]>>Nc1cc(-c2ccc(OC(F)(F)F)cc2)sc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.CN(C)c1ccncc1.Nc1cc(Cl)ncc1F.O=C([O-])O.[Na+]>>CC(=O)Nc1cc(Cl)ncc1F",
        "output": "6"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)c1ccc(OCCCCCCCBr)cc1.C[O-].[Na+]>>COCCCCCCCOc1ccc(C(=O)OC)cc1",
        "output": "95"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.CN1CCCc2ccc(N)cc21.Cc1nc(-c2ccc(F)cc2)ccc1C(=O)O.Cl.ClCCl>>Cc1nc(-c2ccc(F)cc2)ccc1C(=O)Nc1ccc2c(c1)N(C)CCC2",
        "output": "739"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1OC2CNC1C2.O=C(Cl)c1ccc2nonc2c1>>O=C(c1ccc2nonc2c1)N1CC2CC1CO2",
        "output": "201"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(C)=O.Cc1ccc(CN2CCC(O)CC2)cc1.ClCCl.O=C(Cl)C(=O)Cl.[Cl-].[NH4+]>>Cc1ccc(CN2CCC(=O)CC2)cc1",
        "output": "87"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCCCC.CCOC(C)=O.Fc1ccc(S)cc1.OCCCBr.[Na+].[OH-]>>OCCCSc1ccc(F)cc1",
        "output": "124"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1=CCCCC1.CCO.N#Cc1cccc(N(C(=O)NC2CCN(Cc3ccccc3)CC2)C2CCCCCC2)c1.[OH-].[OH-].[Pd+2]>>N#Cc1cccc(N(C(=O)NC2CCNCC2)C2CCCCCC2)c1",
        "output": "84"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)[C@@H](CO)NC(=O)C1(NC(=O)OCc2ccccc2)CCCCC1.CCN(C(C)C)C(C)C.CS(C)=O.ClCCl>>CC(C)[C@@H](C=O)NC(=O)C1(NC(=O)OCc2ccccc2)CCCCC1",
        "output": "142"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1nc(-c2cncc(F)c2)c2c(cc(-c3ccccc3)c(=O)n2Cc2ccccc2)c1O.C[O-].NCCC(=O)O.O=C([O-])O.[Na+].[Na+]>>O=C(O)CCNC(=O)c1nc(-c2cncc(F)c2)c2c(cc(-c3ccccc3)c(=O)n2Cc2ccccc2)c1O",
        "output": "487"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCCNc1c([N+](=O)[O-])cnc2ccccc12.CCOC(C)=O.[Pt]>>CC(C)(C)OC(=O)NCCNc1c(N)cnc2ccccc12",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1cn(-c2ccc(CBr)cc2)c2c(Cl)c(N3CCN(c4ccccn4)CC3)c(F)cc2c1=O.ClCCl.NC1CCCC1>>CCOC(=O)c1cn(-c2ccc(CNC3CCCC3)cc2)c2c(Cl)c(N3CCN(c4ccccn4)CC3)c(F)cc2c1=O",
        "output": "446"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.Cl.Cl.ClCCl.O=C1NC(c2ccc(Cl)cc2Cl)=NC12CCNCC2.O=S(=O)(Cl)c1ccc(Cl)cc1>>O=C1NC(c2ccc(Cl)cc2Cl)=NC12CCN(S(=O)(=O)c1ccc(Cl)cc1)CC2",
        "output": "99"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC2CC(CO)CC(=O)C2C1.CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCC2CC(=O)C3CN(C(=O)OC(C)(C)C)CC3C2)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)NC(=O)OC[C@H]1C[C@@H](NS(=O)(=O)c2cc(Br)ccc2Br)CN1.CCN(C(C)C)C(C)C.ClCCl.N#CBr.NC(CO)(CO)CO>>CC(C)(C)NC(=O)OC[C@H]1C[C@@H](NS(=O)(=O)c2cc(Br)ccc2Br)CN1C#N",
        "output": "532"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)NC1CCNCC1.COc1cccc(Cl)n1.CS(C)=O.O.O=C([O-])[O-].[K+].[K+]>>COc1cccc(N2CCC(NC(C)=O)CC2)n1",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOCC1CCCc2[nH]c3cnc(C(=O)OCC)c(COC)c3c21.Cl.[Na+].[OH-]>>CCOCC1CCCc2[nH]c3cnc(C(=O)O)c(COC)c3c21",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.Cc1nc2ccccc2nc1CCC(=O)O.Cl.Nc1ccccc1N.O=C([O-])[O-].[Na+].[Na+]>>Cc1nc2ccccc2nc1CCc1nc2ccccc2[nH]1",
        "output": "512"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O=C1c2ccccc2C(=O)N1Cc1ccccc1[N+](=O)[O-].O=C[O-].[NH4+].[Ni]>>Nc1ccccc1CN1C(=O)c2ccccc2C1=O",
        "output": "588"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CNC(=O)[C@@H](NC(=O)n1nc(-c2ccc(F)c(F)c2)c2c1CCC(O)C2)C(C)(C)C.CNC(=O)[C@@H](NC(=O)n1nc(-c2ccc(F)c(F)c2)c2c1CCC1(C2)OCCO1)C(C)(C)C.Cc1ccc(S(=O)(=O)O)cc1.O>>CNC(=O)[C@@H](NC(=O)n1nc(-c2ccc(F)c(F)c2)c2c1CCC(=O)C2)C(C)(C)C",
        "output": "87"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCNCC1.COc1cc(C(C)=O)c(O)c(C=O)c1OC.ClCCl.[Na+]>>COc1cc(C(C)=O)c(O)c(CN2CCN(C(=O)OC(C)(C)C)CC2)c1OC",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)C1CN(C(=O)OC(C)(C)C)CCO1.ClCCl.O=C(O)C(F)(F)F>>CC(=O)C1CNCCO1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)c1ccc2c(c1)OC1(O)c3cccc([N+](=O)[O-])c3C(=O)C21NC(=O)Cn1cnnn1.CCO.Cl.O.[Fe]>>CC(C)c1ccc2c(c1)OC1(O)c3cccc(N)c3C(=O)C21NC(=O)Cn1cnnn1",
        "output": "706"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CS(=O)c1cc2nccc(Oc3ccc(N)cc3F)c2s1.O=C(Cc1ccccc1)N=C=S>>CS(=O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1",
        "output": "961"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccccc1C.NC(=O)COCCCl.O=C([O-])[O-].[Na+].[Na+].c1ccc(C(c2ccccc2)N2CCNCC2)cc1.c1ccccc1>>NC(=O)COCCN1CCN(C(c2ccccc2)c2ccccc2)CC1",
        "output": "138"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCc1nc2c(cc1C(=O)OC)C(=O)N(C1CCN(Cc3cc(C4CC4)c(-c4ccccc4)cc3OCC)CC1)CC2.CCOC(C)=O.CO.Cl.[Na+].[OH-]>>CCCc1nc2c(cc1C(=O)O)C(=O)N(C1CCN(Cc3cc(C4CC4)c(-c4ccccc4)cc3OCC)CC1)CC2",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCN(CC)c1ccc(N)cc1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Cl>>CCN(CC)c1ccc(Nc2nc3ccc(OC)cc3c3c[nH]nc23)cc1",
        "output": "998"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCBr.CCOC(C)=O.CN(C)C=O.O.O=C([O-])[O-].Oc1c(F)cc(C2=CC3(CCN(Cc4ccccc4)CC3)Oc3ccccc32)cc1F.[Cs+].[Cs+]>>C=CCOc1c(F)cc(C2=CC3(CCN(Cc4ccccc4)CC3)Oc3ccccc32)cc1F",
        "output": "77"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=C(C)c1ccc2c(Cc3cccc(C(=O)OC)n3)c(-c3ccccc3)nn2c1.CO.Cl.[K+].[OH-]>>C=C(C)c1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1",
        "output": "152"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCN(CC)CC.CN(C)C=O.Nc1ncc(C(=O)c2ccccc2Cl)s1.O=C(O)C1(c2ccc3c(c2)OCO3)CC1.O=S(Cl)Cl>>O=C(c1cnc(NC(=O)C2(c3ccc4c(c3)OCO4)CC2)s1)c1ccccc1Cl",
        "output": "681"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C(N)C#N.CCN(CC)CC.CCOC(C)=O.ClCCl.O.O=C(Cl)c1ccnc(Cl)c1>>CC(C)C(C#N)NC(=O)c1ccnc(Cl)c1",
        "output": "271"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CN(C)C=O.Fc1ccc(CBr)cc1.O=C([O-])[O-].O=Cc1cc(F)ccc1O.[Cl-].[K+].[K+].[NH4+]>>O=Cc1cc(F)ccc1OCc1ccc(F)cc1",
        "output": "127"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)C1=C(c2ccnn2C(C)C)CN(C(=O)OC(C)(C)C)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)n1nccc1C1=C(CO)CCN(C(=O)OC(C)(C)C)C1",
        "output": "150"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1CN(c2ccc(N3C[C@H](CN)OC3=O)cc2F)CCC1=CC#N.N#CCC(=O)O>>CC1CN(c2ccc(N3C[C@H](CNC(=O)CC#N)OC3=O)cc2F)CCC1=CC#N",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)[C@@H]1CCN(C(=O)OC(C)(C)C)[C@H]1c1cc([N+](=O)[O-])ccc1S(=O)(=O)C1CC1.CO.[H][H].[Pd]>>CCOC(=O)[C@@H]1CCN(C(=O)OC(C)(C)C)[C@H]1c1cc(N)ccc1S(=O)(=O)C1CC1",
        "output": "71"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)c1ccccc1CN1CN(c2ccccc2)C2(CCN(CCCN3C(=O)C4(CC4)c4ccccc43)CC2)C1=O.CC[SiH](CC)CC.O=CO>>O=C(O)c1ccccc1CN1CN(c2ccccc2)C2(CCN(CCCN3C(=O)C4(CC4)c4ccccc43)CC2)C1=O",
        "output": "752"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.Cl.O=C(CN1CCNCC1)c1ccc(F)cc1.O=C(O)c1n[nH]cc1Cl>>O=C(CN1CCN(C(=O)c2n[nH]cc2Cl)CC1)c1ccc(F)cc1",
        "output": "663"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrC(Br)(Br)Br.CCOC(=O)C(C)(C)Oc1ccc(CCO)cc1.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)C(C)(C)Oc1ccc(CCBr)cc1",
        "output": "378"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1c(C)c(S(=O)(=O)N2CCCOCC2)c(C)n1Cc1cc(-c2ccc(Cl)s2)on1.O>>Cc1c(S(=O)(=O)N2CCCOCC2)c(C)n(Cc2cc(-c3ccc(Cl)s3)on2)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C)C(=O)N=NC(=O)N(C)C.O=c1c(-c2ccccc2Cl)cc(CO)cn1-c1ccccc1.Oc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=c1c(-c2ccccc2Cl)cc(COc2ccccc2)cn1-c1ccccc1",
        "output": "550"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(C)(C)O.CCN(C(C)C)C(C)C.Fc1ncccc1C(F)(F)F.Oc1ncnc2c1CCNCC2>>Oc1ncnc2c1CCN(c1ncccc1C(F)(F)F)CC2",
        "output": "756"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.CSc1ncc(Br)cn1.O.O=S([O-])OO.[K+].[Na+].[OH-]>>CS(=O)(=O)c1ncc(Br)cn1",
        "output": "840"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(CCc2noc3c(CO)c(O)ccc23)CC1.CC(C)=O.N#Cc1ccc(CBr)cc1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCC(CCc2noc3c(CO)c(OCc4ccc(C#N)cc4)ccc23)CC1",
        "output": "127"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Fc1cccc(F)c1CBr.O=C([O-])[O-].O=S(=O)(Cc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1)c1ccc(F)cc1.[K+].[K+]>>O=S(=O)(Cc1ccc(C(OCc2c(F)cccc2F)(C(F)(F)F)C(F)(F)F)cc1)c1ccc(F)cc1",
        "output": "464"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=C[C@@H]1C[C@]1(N)C(=O)NS(=O)(=O)c1cccc(OCc2ccccc2)c1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[B-](F)(F)F.O=C(O)[C@H]1CN(Cc2cccc3ccccc23)C[C@@H]1Cc1ccc(Cl)cc1>>C=C[C@@H]1C[C@]1(NC(=O)[C@H]1CN(Cc2cccc3ccccc23)C[C@@H]1Cc1ccc(Cl)cc1)C(=O)NS(=O)(=O)c1cccc(OCc2ccccc2)c1",
        "output": "133"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.CN(C)c1ccncc1.Cc1noc(C)c1-c1cc(C(N)=O)c2c(c1)c1ccc(N)cc1n2CC1CC1.ClCCl.c1ccncc1>>CC(=O)Nc1ccc2c3cc(-c4c(C)noc4C)cc(C(N)=O)c3n(CC3CC3)c2c1",
        "output": "9"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cc(-c2ccc(Cl)c(Cl)c2)nc(Cl)n1.OB(O)c1cccc(Br)c1>>Cc1cc(-c2ccc(Cl)c(Cl)c2)nc(-c2cccc(Br)c2)n1",
        "output": "874"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc2c(Cl)ncnc2cc1OCCCS(C)(=O)=O.Oc1ccc2[nH]ccc2c1>>COc1cc2c(Oc3ccc4[nH]ccc4c3)ncnc2cc1OCCCS(C)(=O)=O",
        "output": "668"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CN(C(=O)Oc1ccc(NCC(=O)OC(C)(C)C)cn1)c1ccccc1.ClCCl.O=C(O)C(F)(F)F>>CN(C(=O)Oc1ccc(NCC(=O)O)cn1)c1ccccc1",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cc1c(B2OC(C)(C)C(C)(C)O2)cnn1C.Cc1ccccc1.Cc1nnc2n1-c1ccc(Br)cc1N(c1ccc(Cl)cc1)C[C@H]2C.O.O=C([O-])[O-].[Cs+].[Cs+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1c(-c2ccc3c(c2)N(c2ccc(Cl)cc2)C[C@@H](C)c2nnc(C)n2-3)cnn1C",
        "output": "971"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCCCOC(=O)c1nc(O)c2cc(Br)ccc2c1O.O=P(Cl)(Cl)Cl>>CCCCOC(=O)c1nc(Cl)c2cc(Br)ccc2c1O",
        "output": "41"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC[C@@H]1[C@H](c1ccc(Cl)c(Cl)c1)N1C(=O)c2ccccc2C1=O.ClCCCl.[Na+]>>CN1CCC[C@@H]1[C@H](c1ccc(Cl)c(Cl)c1)N1C(=O)c2ccccc2C1=O",
        "output": "881"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.OCc1ccc2cc(OC3CCC4(CCCCC4)CC3)ccc2c1>>O=Cc1ccc2cc(OC3CCC4(CCCCC4)CC3)ccc2c1",
        "output": "179"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.N.N#Cc1cccnc1Oc1cccnc1.[Ni]>>NCc1cccnc1Oc1cccnc1",
        "output": "560"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.Cl.NC(=O)c1ccc(NC(=O)C2CCN(Cc3ccccc3)CC2)cc1.O=C[O-].[NH4+].[Pd]>>NC(=O)c1ccc(NC(=O)C2CCNCC2)cc1",
        "output": "84"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Clc1cccc(Nc2ccc3ncc(Cc4ccc5ncccc5c4)n3n2)c1.Nc1cccc(Cl)c1.Nc1ccccc1>>c1ccc(Nc2ccc3ncc(Cc4ccc5ncccc5c4)n3n2)cc1",
        "output": "253"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CC[C@@H](C[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C.CC#N.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.Ic1ccc(OCc2ccccc2)cc1.[Pd+2]>>CC(C)(C)OC(=O)N[C@@H](C[C@H](C/C=C/c1ccc(OCc2ccccc2)cc1)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C",
        "output": "725"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.CS(N)(=O)=O.Cl.ClCCl.O.O=C(O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1>>CS(=O)(=O)NC(=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1",
        "output": "580"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C[AlH]CC(C)C.CCOCC.COC(=O)Cc1c(Cl)ncnc1Cl>>OCCc1c(Cl)ncnc1Cl",
        "output": "343"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COCCCOc1ccnc(CO)c1C.ClCCl.O=S(Cl)Cl>>COCCCOc1ccnc(CCl)c1C",
        "output": "594"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CCS(=O)(=O)c1ccc(-c2sc3cc(OCc4ccccc4)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1.CO.O=C[O-].[NH4+].[OH-].[OH-].[Pd+2]>>CCS(=O)(=O)c1ccc(-c2sc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)CCCCOc1cccc(OC)c1C=O.CCOCC.Cl.[I-].[I-].[Mg+2]>>CCOC(=O)CCCCOc1cccc(O)c1C=O",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Cc1cc(-c2cc([N+](=O)[O-])ccc2Cl)cc2nnc(N)nc12.O=S(=O)(NCCN1CCCC1)c1ccc(Br)cc1.[K+].[Pd+2]>>Cc1cc(-c2cc([N+](=O)[O-])ccc2Cl)cc2nnc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nc12",
        "output": "970"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#CC1(C)CC1.C1COCCO1.CC(C)NC(C)C.CCOC(C)=O.COC(=O)c1sc(Br)cc1Br.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>COC(=O)c1sc(C#CC2(C)CC2)cc1Br",
        "output": "766"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(N)C1CCC2(CC1)OCCO2.Cl.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCC(NC(=O)C(F)(F)F)C1CCC2(CC1)OCCO2",
        "output": "316"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cc1cn(-c2cccc(N)c2)cn1.Cl.ClCCl.O=C(O)c1cccc2c1[nH]c1ccccc12>>Cc1cn(-c2cccc(NC(=O)c3cccc4c3[nH]c3ccccc34)c2)cn1",
        "output": "739"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1.[Na+].[OH-]>>O=C(O)c1ccc(OCc2ccc3ccccc3n2)cc1",
        "output": "222"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)c1cc(NC(=O)OCC(Cl)(Cl)Cl)nnc1Cl.CCOC(C)=O.Cl.Cl.Fc1cccc(-c2nccc(N3CCNCC3)n2)c1F>>CC(C)c1cc(NC(=O)N2CCN(c3ccnc(-c4cccc(F)c4F)n3)CC2)nnc1Cl",
        "output": "980"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.O=[N+]([O-])O.c1ccc2c(c1)OCO2>>O=[N+]([O-])c1ccc2c(c1)OCO2",
        "output": "21"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCOC(=O)COc1ccc(F)c(C)c1.[K+].[OH-]>>Cc1cc(OCC(=O)O)ccc1F",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Nc1cnc(-n2nccn2)c(F)c1.O=C(O)C(F)(F)F>>Nc1cnc(-n2nccn2)c(F)c1",
        "output": "877"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)Cc1cc2c([N+](=O)[O-])c(F)ccc2cn1.O.[Ni]>>CC(C)Cc1cc2c(N)c(F)ccc2cn1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Nc1ccc(C(O)CNC2CC2)cc1F.Cl>>Nc1ccc(C(O)CNC2CC2)cc1F",
        "output": "66"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CO.N#CCn1ccc2ccc([N+](=O)[O-])cc21.O.[Cl-].[Fe].[NH4+]>>N#CCn1ccc2ccc(N)cc21",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1nc(C(=O)O)c(-c2ccc(F)cc2)s1.c1cnc2cc(CC3CCCCN3)oc2c1>>Cc1nc(C(=O)N2CCCCC2Cc2cc3ncccc3o2)c(-c2ccc(F)cc2)s1",
        "output": "747"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(Nc2c(F)cc(C(N)=O)cc2Cl)CC1.Cl>>NC(=O)c1cc(F)c(NC2CCNCC2)c(Cl)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.ClCCl.NC[C@@H]1C[C@@H](F)CN1C(=O)Nc1cn(C(N)=O)c2ccccc12.O.O=C(Cl)Cc1ccccc1>>NC(=O)n1cc(NC(=O)N2C[C@H](F)C[C@H]2CNC(=O)Cc2ccccc2)c2ccccc21",
        "output": "45"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.ClC(Cl)Cl.O=C([O-])[O-].O=Cc1ccc(F)c(Br)c1.[K+].[K+].c1c[nH]cn1>>O=Cc1ccc(-n2ccnc2)c(Br)c1",
        "output": "721"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.Cc1ccccc1.OCCN1CCNCC1>>CC(=O)N1CCN(CCO)CC1",
        "output": "369"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)C(C)Sc1nc(Nc2ccc(S(N)(=O)=O)nc2)ncc1Br.C[Mg]Br>>CC(Sc1nc(Nc2ccc(S(N)(=O)=O)nc2)ncc1Br)C(C)(C)O",
        "output": "514"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)c1cc(O)n2nccc2n1.[Na+].[OH-]>>O=C(O)c1cc(O)n2nccc2n1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=O.CC#N.CCN(CC)CC.CCOCC.Cl.O=C(Cc1ccc(O)cc1)OCc1ccccc1.[Cl-].[Cl-].[Mg+2]>>O=Cc1cc(CC(=O)OCc2ccccc2)ccc1O",
        "output": "451"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.NC(=O)C1CCc2[nH]c3ccc(OC(F)(F)F)cc3c2C1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCC1CCc2[nH]c3ccc(OC(F)(F)F)cc3c2C1",
        "output": "112"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(C)=O.CN.CN(C)C=O.Cl.ClCCl.O.O=C(Cl)C(=O)Cl.O=C(O)C(c1ccc(F)cc1)c1ccc(F)cc1.[Na+].[OH-]>>CNC(=O)C(c1ccc(F)cc1)c1ccc(F)cc1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(CCCN(CC)CC)Nc1c2ccccc2nc2ccccc12.CCN(CC)CC.CCNCCCC(C)N.Cl.Cl.Clc1c2ccccc2nc2ccccc12.Oc1ccccc1>>CCNCCCC(C)Nc1c2ccccc2nc2ccccc12",
        "output": "78"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.NC(=O)c1ccc(C(O)c2c(OCc3ccccc3)c(=O)ccn2CCO)cc1.[Pd]>>NC(=O)c1ccc(C(O)c2c(O)c(=O)ccn2CCO)cc1",
        "output": "264"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CCOCC.CO.O=C(O)CCc1cccs1>>OCCCc1cccs1",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cl.O=Cc1ccc(F)c(F)c1.OCC(F)(F)F.[H-].[Na+]>>O=Cc1ccc(OCC(F)(F)F)c(F)c1",
        "output": "485"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCCC1=O.COc1cc(-n2cccn2)ccc1C(=O)O.ClCCl.O=S(Cl)Cl>>COc1cc(-n2cccn2)ccc1C(=O)Cl",
        "output": "3"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cccc2cc(C(=O)O)c(=O)oc12.F[P-](F)(F)(F)(F)F.Nc1cccc(-c2ccccc2OC(F)(F)F)c1>>COc1cccc2cc(C(=O)Nc3cccc(-c4ccccc4OC(F)(F)F)c3)c(=O)oc12",
        "output": "799"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#CCOc1ccc(C[C@H](NC(=O)[C@@H](/C=C/CCCCCCC(F)(F)CCCCCCC)[C@@](O)(CCC)C(=O)O)C(=O)O)cc1.CC#CCOc1ccc(C[C@H](NC(=O)[C@@H](/C=C/CCCCCCS(=O)(=O)CCCCCCC)[C@@](O)(CCC)C(=O)O)C(=O)OC)cc1>>CC#CCOc1ccc(C[C@H](NC(=O)[C@@H](/C=C/CCCCCCS(=O)(=O)CCCCCCC)[C@@](O)(CCC)C(=O)O)C(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1[nH]c(C=O)c(C)c1CCCN(C)C.O=C1Cc2cc(Cl)ccc2N1>>Cc1[nH]c(C=C2C(=O)Nc3ccc(Cl)cc32)c(C)c1CCCN(C)C",
        "output": "440"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=CBr)c1ccc(F)c(F)c1.CN(C)C=O.CN1CCc2[nH]c3ccc(Cl)cc3c2C1.O=C(O)[C@@H]1CCCN1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>C/C(=C\\n1c2c(c3cc(Cl)ccc31)CN(C)CC2)c1ccc(F)c(F)c1",
        "output": "987"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrBr.CC(C)(C(=O)O)c1ccccc1.ClC(Cl)(Cl)Cl.[Fe]>>CC(C)(C(=O)O)c1ccc(Br)cc1",
        "output": "98"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(Cn2cc3c(n2)CC(O)CCC3=O)cc1.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>COc1ccc(Cn2cc3c(n2)CC(=O)CCC3=O)cc1",
        "output": "87"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cc1ccc([N+](=O)[O-])cc1-c1cnn(C)c1.[Fe]>>Cc1ccc(N)cc1-c1cnn(C)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)NC(=O)[C@@H]1C[C@H](Cl)CN1C(=O)[C@@H](O)[C@@H](N)Cc1ccccc1.CC(C)(C)OC(=O)N[C@@H](CC(N)=O)C(=O)O.CCN(CC)CC.CN(C)C=O.N#N>>CC(C)(C)NC(=O)[C@@H]1C[C@H](Cl)CN1C(=O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OC(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=C([O-])[O-].O=[N+]([O-])c1ccc(O)c(F)c1.O=c1ncc(-c2cc3nccc(Cl)c3s2)cn1CCN1CCOCC1.[K+].[K+].c1ccc(Oc2ccccc2)cc1>>O=c1ncc(-c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)cn1CCN1CCOCC1",
        "output": "936"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(C)C=O.CO.COC(=O)c1ccc2nc(NCC3(F)CCNCC3)[nH]c2c1.Cl.O=Cc1cc(Cl)cc(Cl)c1O.[Na+]>>COC(=O)c1ccc2nc(NCC3(F)CCN(Cc4cc(Cl)cc(Cl)c4O)CC3)[nH]c2c1",
        "output": "567"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)c1coc(CN2C(=O)C3(COc4cc5c(cc43)OCO5)c3ccccc32)n1.Cl.O.[Na+].[OH-]>>O=C(O)c1coc(CN2C(=O)C3(COc4cc5c(cc43)OCO5)c3ccccc32)n1",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.CO.Cc1ccc(S(=O)(=O)O)cc1.Nc1ccc(C=O)cc1.O.O.O=C1CCC(=O)N1Br>>Nc1ccc(C=O)cc1Br",
        "output": "4"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cn(C(CCOC(F)(F)F)C(=O)OC(C)(C)C)c(=O)cc1-c1cc(Cl)ccc1C#N.ClCCl.O=C(O)C(F)(F)F>>COc1cn(C(CCOC(F)(F)F)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1C#N",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2ccccc2)cc1.Cl.c1ccncc1>>O=C(c1ccccc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12",
        "output": "20"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)c1nccs1)OC)N(C)C(=O)[C@@H](N)C(C)C.CN(C)[P+](Br)(N(C)C)N(C)C.ClCCl.F[P-](F)(F)(F)(F)F.NC1(C(=O)O)CCCCC1>>CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)c1nccs1)OC)N(C)C(=O)[C@@H](NC(=O)C1(N)CCCCC1)C(C)C",
        "output": "133"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cc1ccc2ccc(C#C[Si](C)(C)C)cc2n1.O=C([O-])[O-].[K+].[K+]>>C#Cc1ccc2ccc(C)nc2c1",
        "output": "337"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCO.NNc1cc(N2CCOCC2)n2nc(-c3ccccc3)cc2n1.O=Cc1cccc2[nH]ccc12>>C(=NNc1cc(N2CCOCC2)n2nc(-c3ccccc3)cc2n1)c1cccc2[nH]ccc12",
        "output": "167"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "N=C(NO)c1ccc(F)cc1F.O=C(O)C1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)N2CC(O)C2)C1>>O=C(N1CC(O)C1)N1CC(c2ccc(C(F)(F)F)cc2)CC(c2nc(-c3ccc(F)cc3F)no2)C1",
        "output": "895"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2CC.CN(C)C=O.O.O=C(CBr)N1CCCC1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCC(=O)N3CCCC3)cc1CC2CC",
        "output": "778"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cnc(N)c2ncn(CCCl)c12.CO.Cc1ccccc1.[Na+].[OH-]>>Nc1ncc(C(=O)O)c2c1ncn2CCCl",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1ccc2c(c1)nc(-c1ccc(N)cc1)n2C1CCCC1.ClC(Cl)Cl.O=C(Cl)c1ccccc1.c1ccncc1>>CCOC(=O)c1ccc2c(c1)nc(-c1ccc(NC(=O)c3ccccc3)cc1)n2C1CCCC1",
        "output": "11"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.CC(C)(C)OC(=O)N1CCN2c3ccccc3NC(=O)CC2C1.CO.Cl.ClCCl.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N1CCN2c3ccccc3NCCC2C1",
        "output": "112"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.C[C@@]1(c2ccc3cc(O)ccc3c2)COC(=O)N1.ClCCl.OC1CCC2(CCCCC2)CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C[C@@]1(c2ccc3cc(OC4CCC5(CCCCC5)CC4)ccc3c2)COC(=O)N1",
        "output": "846"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4cnc5cccc(C)n45)cc2)CCN3CC(C)C)cc1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=S([O-])([O-])=S.[Na+].[Na+]>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4cnc5cccc(C)n45)cc2)CCN3CC(C)C)cc1",
        "output": "500"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Clc1ccc2c(Br)cccc2n1.O=C([O-])O.[H-].[Na+].[Na+]>>COc1ccc2c(Br)cccc2n1",
        "output": "433"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)CC1.CCOC(C)=O.CN(C)C=O.Clc1ccnc(Cl)n1.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)(C)OC(=O)N1CCC(Oc2ccnc(Cl)n2)CC1",
        "output": "653"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(C)=O.CSCc1cccc2c(C(CCOS(C)(=O)=O)(c3ccc(Cl)cc3)C3CC3)c[nH]c12.O.[C-]#N.[K+]>>CSCc1cccc2c(C(CCC#N)(c3ccc(Cl)cc3)C3CC3)c[nH]c12",
        "output": "705"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CO)C(C)C)ccc1C.CS(=O)(=O)Cl.ClCCl>>COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2COS(C)(=O)=O)C(C)C)ccc1C",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccccc1.O=C1C(Cc2ccccc2)NC2(CCNCC2)N1Cc1ccccc1.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)N1CCC2(CC1)NC(Cc1ccccc1)C(=O)N2Cc1ccccc1",
        "output": "323"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN(C)C=O.Cn1cccc1C(=O)O.Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)c1.O.O=C(Cl)C(=O)Cl>>Cn1cccc1C(=O)Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)c1",
        "output": "548"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.OB(O)c1ccccc1.Oc1ccc(Br)c(C(F)(F)F)c1>>FC(F)(F)c1cc(Oc2ccccc2)ccc1Br",
        "output": "920"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCCCCCOc1ccc(-n2c(C)ccc2-c2ccc(O[C@H](Cc3ccccc3)C(=O)OCC)cc2)cc1.CO.Cl.[K+].[OH-]>>CCCCCCCOc1ccc(-n2c(C)ccc2-c2ccc(O[C@H](Cc3ccccc3)C(=O)O)cc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CCOCC1.CS(C)=O.Cc1cc(C)c(CN)c(=O)[nH]1.Cc1nn(C2CC2)c2nc(Cl)cc(C(=O)O)c12.ClCCCl.O.On1nnc2cccnc21>>Cc1cc(C)c(CNC(=O)c2cc(Cl)nc3c2c(C)nn3C2CC2)c(=O)[nH]1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.O=C(O)c1ccc(F)c([N+](=O)[O-])c1.O=C([O-])O.O=S(=O)(O)O.O=S(=O)([O-])[O-].[Mg+2].[Na+]>>CCOC(=O)c1ccc(F)c([N+](=O)[O-])c1",
        "output": "33"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)Cc1cc(I)c(Oc2ccc(OC)cc2)c(I)c1.O=C(O)C(=O)O.[Li+].[OH-]>>COc1ccc(Oc2c(I)cc(CC(=O)O)cc2I)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1ccc(S)cc1.O=C1Nc2ccc(OCCCCCl)cc2C(C2CCCCC2)(C2CCCCC2)O1>>CC(=O)Nc1ccc(SCCCCOc2ccc3c(c2)C(C2CCCCC2)(C2CCCCC2)OC(=O)N3)cc1",
        "output": "460"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O=C(Cl)c1ccc2c(c1)C(=O)c1ccccc1CO2.O=C(O)CCO.[Na]>>O=C(O)CCOC(=O)c1ccc2c(c1)C(=O)c1ccccc1CO2",
        "output": "51"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1cc([N+](=O)[O-])cc2c(O)nc(Nc3ccc(F)cc3)nc12.Cl.O.O.[Li+].[OH-]>>O=C(O)c1cc([N+](=O)[O-])cc2c(O)nc(Nc3ccc(F)cc3)nc12",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.COC(=O)C1CCN(C(=O)OC)C(c2ccc(C(C)(C)C)s2)C1.COC(C)(C)C.O.[Br-].[Li+]>>COC(=O)N1CCC(C(=O)O)CC1c1ccc(C(C)(C)C)s1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](C)(C)OCC(CCCc1cc[n+]([O-])cc1)CO[Si](C)(C)C(C)(C)C.CN(C)C(=O)Cl.C[Si](C)(C)C#N.ClC(Cl)Cl.O=C([O-])O.[Na+]>>CC(C)(C)[Si](C)(C)OCC(CCCc1ccnc(C#N)c1)CO[Si](C)(C)C(C)(C)C",
        "output": "720"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc(F)cc1-c1ccncc1.c1ccncc1>>O=S(=O)(Oc1ccc(F)cc1-c1ccncc1)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)c1cnc(N2CC3C(C2)C3Nc2ccc3ccccc3n2)nc1.O>>O=C(O)c1cnc(N2CC3C(C2)C3Nc2ccc3ccccc3n2)nc1",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1ccc2nc(Nc3ccc(OC)cc3)n(CCCN3CCCCC3)c2n1.CO.[Li+].[OH-]>>COc1ccc(Nc2nc3ccc(C(=O)O)nc3n2CCCN2CCCCC2)cc1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC1CCC(C2CCC(OCCCO)CC2)CC1.CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.[Cl-].[NH4+]>>CCCC1CCC(C2CCC(OCCC=O)CC2)CC1",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.COc1cccc(C(=O)CBr)c1.O=C([O-])[O-].[K+].[K+].c1ccc(-c2cccnc2N2CCNCC2)nc1>>COc1cccc(C(=O)CN2CCN(c3ncccc3-c3ccccn3)CC2)c1",
        "output": "413"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN.Cl.O=C(O)CCCC(=O)Nc1ccc(-c2cnc([C@@H]3CCc4cc(-c5cc(Cl)ccc5-n5cnnn5)cc(=O)n43)[nH]2)cc1.O=CO>>CNC(=O)CCCC(=O)Nc1ccc(-c2cnc([C@@H]3CCc4cc(-c5cc(Cl)ccc5-n5cnnn5)cc(=O)n43)[nH]2)cc1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.COC(=O)c1ccc(O)cc1.ClCCCBr.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(OCCCCl)cc1",
        "output": "385"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)C1COc2cc(-n3cnnn3)ccc21.O.O.[Li]O>>O=C(O)C1COc2cc(-n3cnnn3)ccc21",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C1CCNCC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@@H]1CCCN1CCc1ccc(-c2ccc(CCC(=O)O)cc2)cc1.Cl.F[P-](F)(F)(F)(F)F>>CCOC(=O)C1CCN(C(=O)CCc2ccc(-c3ccc(CCN4CCC[C@H]4C)cc3)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC(O[Si](C)(C)C(C)(C)C)C1.ClCCl.O=C(O)C(F)(F)F>>CC(C)(C)[Si](C)(C)OC1CNC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.C[C@H](CN1CC[C@@H](F)C1)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12.ClCCl.NCCN.O.O=C(O)C(F)(F)F>>C[C@H](CN1CC[C@@H](F)C1)NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12",
        "output": "981"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.OCCCOc1c(Cl)cc(OCc2ccccc2)cc1Cl.[H][H].[Pd]>>OCCCOc1c(Cl)cc(O)cc1Cl",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)O.N#Cc1ccc(O)c(C(F)(F)F)c1.O=C(/N=N/C(=O)OCc1ccccc1)OCc1ccccc1.O=C(O)C(F)(F)F.[Na+].[OH-].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)Oc1ccc(C#N)cc1C(F)(F)F",
        "output": "846"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COc1ccccc1-c1cc(C(F)(F)F)no1.COc1ccccc1C(=O)CC(=O)C(F)(F)F.Cl.NO>>Oc1ccccc1-c1cc(C(F)(F)F)no1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)c1cc(C(=O)N2CCCC(c3ccccc3F)C2)ccn1.CN(C)c1cc(C(=O)O)cnn1.Cc1cc(Cl)ccc1C1CCCNC1.Cl>>Cc1cc(Cl)ccc1C1CCCN(C(=O)c2cnnc(N(C)C)c2)C1",
        "output": "256"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1ccc(Cl)cc1NC(=O)Oc1ccccc1.Nc1ccc(S(N)(=O)=O)cc1>>COC(=O)c1ccc(Cl)cc1NC(=O)NS(=O)(=O)c1ccc(N)cc1",
        "output": "690"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CCn1c(=O)cc(O)c2cc(C)ccc21.O=[N+]([O-])O>>CCn1c(=O)c([N+](=O)[O-])c(O)c2cc(C)ccc21",
        "output": "328"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COc1ccc(C(=O)Cc2ccccc2)cc1F.Cc1ccccc1.Cl.NO.O.[K+].[OH-]>>COc1ccc(C(Cc2ccccc2)=NO)cc1F",
        "output": "212"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(CN=[N+]=[N-])Cc1ccc(Cl)cc1.CP(C)C.O>>CCOC(CN)Cc1ccc(Cl)cc1",
        "output": "89"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CO.C[Si](C)(C)C=[N+]=[N-].O=C(O)C1C2CC3CC(C2)CC1C3>>COC(=O)C1C2CC3CC(C2)CC1C3",
        "output": "195"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[Pd]OC(C)=O.CC(C)(C)OC(=O)N1CCNCC1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CCOC(C)=O.Cc1ccc(Br)cc1NC(=O)OC(C)(C)C.Cc1ccccc1.ClCCl>>Cc1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)cc1NC(=O)OC(C)(C)C",
        "output": "294"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(Cl)OC(=O)Cl.CCN(C(C)C)C(C)C.ClCCl.FC(F)(F)c1nnc(NC2CCN(Cc3ccccc3)CC2)s1>>FC(F)(F)c1nnc(NC2CCNCC2)s1",
        "output": "84"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N(C)C.Nc1ccc(S(=O)(=O)c2ncccn2)cc1.O.O=C(O)C(O)(C(F)F)C(F)F.O=C([O-])O.O=S(Cl)Cl.[Na+]>>O=C(Nc1ccc(S(=O)(=O)c2ncccn2)cc1)C(O)(C(F)F)C(F)F",
        "output": "365"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=C(Cl)c1cccc(Cl)c1.O=C1C(=O)c2ccc(-c3ccccc3)cc2C2=C1SCC1(CCNCC1)O2>>O=C1C(=O)c2ccc(-c3ccccc3)cc2C2=C1SCC1(CCN(C(=O)c3cccc(Cl)c3)CC1)O2",
        "output": "201"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cl.FC1(F)CNC1.N#Cc1cccnc1F>>N#Cc1cccnc1N1CC(F)(F)C1",
        "output": "756"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.COC(=O)c1ccc(O)c(OC)c1.ClCCCBr.O=C([O-])[O-].[Cl-].[K+].[K+].[Na+]>>COC(=O)c1ccc(OCCCCl)c(OC)c1",
        "output": "385"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCOc1ccc(C=O)cc1OC.CO.ClCCl.O=C(O)C1CNC1.[BH3-]C#N.[Na+]>>CCCCCCOc1ccc(CN2CC(C(=O)O)C2)cc1OC",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CI.CN(C)C=O.Oc1ccc2c(c1)OCCO2.[H-].[Na+]>>COc1ccc2c(c1)OCCO2",
        "output": "62"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(=O)(=O)c1ccc(F)c([N+](=O)[O-])c1.CS(=O)(=O)c1ccc2c(c1)ncn2C1CCNCC1.CS(C)=O.NC1CCN(Cc2ccccc2)CC1.O=C([O-])[O-].[Na+].[Na+]>>CS(=O)(=O)c1ccc(NC2CCN(Cc3ccccc3)CC2)c([N+](=O)[O-])c1",
        "output": "572"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(Cc2ccc(CC)nc2)c2nc(C)nn12.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(Cc2ccc(CC)nc2)c2nc(C)nn12",
        "output": "979"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCc1ccc([N+](=O)[O-])cc1Br.[Fe]>>CCc1ccc(N)cc1Br",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1cc(F)c(C#N)nc1Nc1ccc([Si](C)(C)C)cc1F.Cl[Co]Cl.[BH4-].[Na+]>>COC(=O)c1cc(F)c(CN)nc1Nc1ccc([Si](C)(C)C)cc1F",
        "output": "205"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCn1cc(C(=O)O)c(=O)c2cc(F)c(Cl)cc21.c1ccncc1.c1coc(C2CNCCN2)c1>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(c4ccco4)C3)cc21",
        "output": "280"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.O.O=C(O)c1cccc2c(O)ncnc12.O=C([O-])O.O=S(=O)(O)O.[Na+]>>CCOC(=O)c1cccc2c(O)ncnc12",
        "output": "521"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCc1nnc(-c2cc(C(=O)OC)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)n1C.[Na+].[OH-]>>CCc1nnc(-c2cc(C(=O)O)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)n1C",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.ClCCl.O=C([O-])O.O=[N+]([O-])c1ccc(F)c(F)c1.Oc1cc2cn[nH]c2cc1Br.[Cl-].[Li+].[Na+]>>O=[N+]([O-])c1ccc(Oc2cc3cn[nH]c3cc2Br)c(F)c1",
        "output": "564"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=C(C)CCC(C)CC=O.CCCCCCC.O=C(O)c1ccccc1>>CC(C)=C(C)CCC(C)CCO",
        "output": "223"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)c1ccc(C(=O)O)cc1N.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC(C)(C)c1ccc(CO)cc1N",
        "output": "72"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN.Cl.O=C(CN1C[C@H](NC(=O)c2ccc(Cl)s2)C[C@H]1C(=O)O)Nc1ccc(-n2ccccc2=O)cc1F>>CNC(=O)[C@@H]1C[C@@H](NC(=O)c2ccc(Cl)s2)CN1CC(=O)Nc1ccc(-n2ccccc2=O)cc1F",
        "output": "216"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=CC(=O)Cl.CC1(O)C2CC3CC(C2)CC1C3.CCC(C)=O.CCN(CC)CC.CO.O.[Cl-]>>C=CC(=O)OC1(C)C2CC3CC(C2)CC1C3",
        "output": "320"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(O)Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.Nc1nc(-c2nc3c(s2)CCOc2cc(Br)ccc2-3)n(-c2ccc(F)cc2F)n1>>CC(C)(O)Cn1cc(-c2ccc3c(c2)OCCc2sc(-c4nc(N)nn4-c4ccc(F)cc4F)nc2-3)cn1",
        "output": "971"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)CC1(C(=O)c2ccc3c(c2)nc(Cc2ccc(C(=N)N)cc2)n3C)CCCCC1.Cl.O.[Na+].[OH-]>>Cn1c(Cc2ccc(C(=N)N)cc2)nc2cc(C(=O)C3(CC(=O)O)CCCCC3)ccc21",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCN(CC)CCN.COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.ClC(Cl)Cl.O.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCN(CC)CCNC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1",
        "output": "913"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.O=[N+]([O-])O.Oc1ccc(Cc2ccccc2)cc1>>O=[N+]([O-])c1cc(Cc2ccccc2)ccc1O",
        "output": "21"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)n1ccc(-c2cc(C(F)(F)F)c3nc(C(=O)O)c(Cl)n3c2)c1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O=C1OCCN1C1CCNCC1>>CC(C)(C)OC(=O)n1ccc(-c2cc(C(F)(F)F)c3nc(C(=O)N4CCC(N5CCOC5=O)CC4)c(Cl)n3c2)c1",
        "output": "729"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCCCCCCCCCc1ccc(OCC(O)CO)c(CCCCCC)c1.ClC(Cl)Cl.ClC(c1ccccc1)(c1ccccc1)c1ccccc1.c1ccncc1>>CCCCCCCCCCCCCCc1ccc(OCC(O)COC(c2ccccc2)(c2ccccc2)c2ccccc2)c(CCCCCC)c1",
        "output": "250"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCCCCCCBr.CC#N.CCCCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.Cc1cc(C)c(SCC(F)(F)F)cc1O.O=C([O-])[O-].[Br-].[K+].[K+]>>Cc1cc(C)c(SCC(F)(F)F)cc1OCCCCCCBr",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNCC1.O=C(O)CC(=O)O.O=Cc1ccc(F)c(Br)c1.c1ccncc1>>O=C(O)C=Cc1ccc(F)c(Br)c1",
        "output": "12"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.O=C([O-])[O-].OCCI.Oc1c(OC(F)(F)F)cccc1C1CCNCC1.[K+].[K+]>>OCCN1CCC(c2cccc(OC(F)(F)F)c2O)CC1",
        "output": "184"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CSc1nccc(-c2ccc(C(=O)N3CCOCC3)s2)n1.O.O=S([O-])OO.[K+]>>CS(=O)(=O)c1nccc(-c2ccc(C(=O)N3CCOCC3)s2)n1",
        "output": "840"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1ccc(-c2cccc(Cl)c2)cn1.O=C(O)CC1CCN2C(=O)OCC2C1>>O=C(CC1CCN2C(=O)OCC2C1)Nc1ccc(-c2cccc(Cl)c2)cn1",
        "output": "368"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)CCC(C)(C)c2cc(C(=O)Cl)ccc21.CCN(CC)CC.ClCCl.O.O=[N+]([O-])c1ccc(CCO)cc1>>CC1(C)CCC(C)(C)c2cc(C(=O)OCCc3ccc([N+](=O)[O-])cc3)ccc21",
        "output": "51"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1cnc(N)c(-c2cc3cc(N)ccc3s2)c1.O=C=Nc1ccccc1>>COC(=O)c1cnc(N)c(-c2cc3cc(NC(=O)Nc4ccccc4)ccc3s2)c1",
        "output": "473"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCc1nc2cnc3cc(OC4CCOC4)ccc3c2n1CC(C)C.O=C(OO)c1cccc(Cl)c1>>CCCc1nc2c[n+]([O-])c3cc(OC4CCOC4)ccc3c2n1CC(C)C",
        "output": "820"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.Cl.ClC(Cl)Cl.O=C(Cl)OCc1ccccc1.O=C([O-])O.O=C1CC2CCC(C1)N2.[Na+]>>O=C1CC2CCC(C1)N2C(=O)OCc1ccccc1",
        "output": "427"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)OB(c2cnc(N)nc2)OC1(C)C.COC(C)(C)c1cc2nc(Cl)nc(N3CCOCC3)c2s1>>COC(C)(C)c1cc2nc(-c3cnc(N)nc3)nc(N3CCOCC3)c2s1",
        "output": "973"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CO.Cl.N#Cc1ccc(OCc2sc(-c3ccc(C(F)(F)F)cc3)nc2CCCOCc2ccccc2)cc1F.NO>>N=C(NO)c1ccc(OCc2sc(-c3ccc(C(F)(F)F)cc3)nc2CCCOCc2ccccc2)cc1F",
        "output": "854"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(F)c(Oc2cc(Cl)cc(C#N)c2)c1F.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>N#Cc1cc(Cl)cc(Oc2c(F)ccc(CBr)c2F)c1",
        "output": "29"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNCC1.CC#N.O=C([O-])[O-].O=[N+]([O-])c1ccc(CCl)cc1.[K+].[K+]>>O=[N+]([O-])c1ccc(CN2CCCCC2)cc1",
        "output": "156"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CS(=O)(=O)c1cccc(B(O)O)c1.Cn1ccc(-c2ccc(Br)s2)n1.O.O=C([O-])[O-].[K+].[K+]>>Cn1ccc(-c2ccc(-c3cccc(S(C)(=O)=O)c3)s2)n1",
        "output": "864"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)C(=O)Nc2cc([N+](=O)[O-])ccc21.CCBr.CN(C)C=O.[H-].[Na+]>>CCN1C(=O)C(C)(C)c2ccc([N+](=O)[O-])cc21",
        "output": "367"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.COC(=O)C(Cc1ccc(Cl)cc1Cl)c1c(Cl)cccc1Cl.Cl.O.[BH4-].[I-].[Li+].[Na+]>>OCC(Cc1ccc(Cl)cc1Cl)c1c(Cl)cccc1Cl",
        "output": "343"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1cccc(-c2cccnc2)c1.O=[Pt]=O>>Nc1cccc(-c2cccnc2)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cl.O=C(Nc1nnn[nH]1)c1cncc(Cl)n1.OC1CCCNC1>>O=C(Nc1nnn[nH]1)c1cncc(N2CCCC(O)C2)n1",
        "output": "505"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)OB(c2ccc(-c3cnc(N)nc3)c(F)c2)OC1(C)C.Nc1cc(Oc2ccccc2Br)ncn1>>Nc1cc(Oc2ccccc2-c2ccc(-c3cnc(N)nc3)c(F)c2)ncn1",
        "output": "933"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1cc(C(=O)O)ccc1O.ClCCCN1CCOCC1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>COc1cc(C(=O)O)ccc1OCCCN1CCOCC1",
        "output": "74"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cl.O=[N+]([O-])c1cc(Br)ccc1-c1ccc(Br)cc1[N+](=O)[O-].[Na+].[OH-]>>Nc1cc(Br)ccc1-c1ccc(Br)cc1N",
        "output": "204"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CN(CCNC(=O)OC(C)(C)C)c1cc(Cl)c(N)cc1C#N.COc1ccc(CN(c2nc(Cl)nn3c(C#N)cnc23)C2CC2)cc1.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].[Pd+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1ccc(CN(c2nc(Nc3cc(C#N)c(N(C)CCNC(=O)OC(C)(C)C)cc3Cl)nn3c(C#N)cnc23)C2CC2)cc1",
        "output": "990"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CC(C)(O)c1cc(C(=O)O)cc(S(F)(F)(F)(F)F)c1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc(N)cc1-n1ccn2nc(-c3cccnc3)c(F)c12.F[P-](F)(F)(F)(F)F>>Cc1ccc(NC(=O)c2cc(C(C)(C)O)cc(S(F)(F)(F)(F)F)c2)cc1-n1ccn2nc(-c3cccnc3)c(F)c12",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)C(C)Oc1ncn(-c2ccccc2Cl)n1.[K+].[OH-]>>CC(Oc1ncn(-c2ccccc2Cl)n1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COc1ccc(C(=O)Cl)cc1.Cc1oc2c(C)c(C)c(O)c(C)c2c1-c1ccc(C(C)C)cc1.ClC(Cl)Cl.O>>COc1ccc(C(=O)Oc2c(C)c(C)c3oc(C)c(-c4ccc(C(C)C)cc4)c3c2C)cc1",
        "output": "482"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1cc(Cl)nc(C)c1C(=O)O.Cc1ccncc1CN(c1ccc(C(F)(F)F)nc1)C1CCN([C@H](C)CCN)CC1.Cl.On1nnc2ccccc21>>Cc1ccncc1CN(c1ccc(C(F)(F)F)nc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN.CSc1ncc2c(n1)N1CCC[C@H]1CN(c1cccc3c(=O)n(C)cnc13)C2=O.ClC(Cl)Cl.ClCCl.O=C(OO)c1cccc(Cl)c1>>CCNc1ncc2c(n1)N1CCC[C@H]1CN(c1cccc3c(=O)n(C)cnc13)C2=O",
        "output": "101"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2cccs2)cc1[N+](=O)[O-].CO.NN.O>>CC(C)(C)OC(=O)Nc1ccc(-c2cccs2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrBr.CCC(=O)c1ccccc1.CCOC(C)=O.ClCCl.O=C([O-])O.[Na+]>>CC(Br)C(=O)c1ccccc1",
        "output": "82"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(=O)(=O)Cl.Cc1cnc(N2CCC(c3ccc(N)cc3)CC2)n1C.c1ccncc1>>Cc1cnc(N2CCC(c3ccc(NS(C)(=O)=O)cc3)CC2)n1C",
        "output": "194"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.CC/C=C\\C=C/CCCCCCCCCCO.O=C([O-])O.[Na+].c1ccncc1>>CC/C=C\\C=C/CCCCCCCCCC=O",
        "output": "142"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCC[N+](CCC)(CCC)CCC.CCOc1c(/C(=C(/F)CO)C(C)C)cc2c(c1Br)C(C)(C)CC=C2C(C)C.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-]>>CCOc1c(/C(=C(/F)C=O)C(C)C)cc2c(c1Br)C(C)(C)CC=C2C(C)C",
        "output": "183"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)CCNc1cc(N)c([N+](=O)[O-])cc1F.CO.[H][H].[Pd]>>CN(C)CCNc1cc(N)c(N)cc1F",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOc1cc2c(c3c1OC(C)(C)C3)C(c1ccccc1)=NC(C)(CN)C2.O.O=C(Cl)CCl.[Na+].[OH-]>>CCOc1cc2c(c3c1OC(C)(C)C3)C(c1ccccc1)=NC(C)(CNC(=O)CCl)C2",
        "output": "45"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(C(C)(C)C)C(C)(C)C.CNc1ccc(Br)cc1[N+](=O)[O-].Cc1ccccc1.FC(F)(F)C1CCNCC1.[Pd+2]>>CNc1ccc(N2CCC(C(F)(F)F)CC2)cc1[N+](=O)[O-]",
        "output": "294"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COCCO.Clc1ncnc2c1CCN(Cc1ccccc1)C2.Nc1ccc(C(F)(F)F)cc1>>FC(F)(F)c1ccc(Nc2ncnc3c2CCN(Cc2ccccc2)C3)cc1",
        "output": "352"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCC(n2cnc(-c3ccccc3)c2-c2ccncn2)CC1.ClCCl.O=C(O)C(F)(F)F>>c1ccc(-c2ncn(C3CCNCC3)c2-c2ccncn2)cc1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc(C(=O)O)c(F)c1.O.[Na+].[OH-]>>CC(C)(C)OC(=O)Nc1ccc(C(=O)O)c(F)c1",
        "output": "735"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N[C@@H](Cc1ccc(N2CC(=O)NS2(=O)=O)c(OCc2ccccc2)c1)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CC(=O)N[C@@H](Cc1ccc(N2CC(=O)NS2(=O)=O)c(OCc2ccccc2)c1)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc2c(n1)c(CCNC(=O)c1ccco1)c1n2CCCC1.ClCCl.O=C([O-])O.[Al+3].[Cl-].[Cl-].[Cl-].[Na+]>>O=C(NCCc1c2n(c3ccc(O)nc13)CCCC2)c1ccco1",
        "output": "408"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOC(C)=O.Cc1ccc(N)cc1N.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)Nc2ccc(C)c(N)c2)cc1",
        "output": "68"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)C(F)(F)C1(O)O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1.O=C=O.[Na+].[OH-]>>O=C(O)C(F)(F)C1(O)O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)O.Cl.N#Cc1ccc2sc(Sc3c(Cl)cc(NS(=O)(=O)c4ccc(Cl)cc4Cl)cc3Cl)nc2c1.[K+].[OH-]>>NC(=O)c1ccc2sc(Sc3c(Cl)cc(NS(=O)(=O)c4ccc(Cl)cc4Cl)cc3Cl)nc2c1",
        "output": "419"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.NS(=O)(=O)c1cc2cc(OCC(=O)O)ccc2s1.O=S(=O)(O)O>>CCOC(=O)COc1ccc2sc(S(N)(=O)=O)cc2c1",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)Cl.CO.COC(=O)CC(NC(=O)OC(C)(C)C)C(=O)O.O=S(=O)([O-])O.[BH4-].[Na+].[Na+]>>COC(=O)CC(CO)NC(=O)OC(C)(C)C",
        "output": "231"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CCN(CC)CC.O.O=C(O)c1cccnc1Br.[BH4-].[Na+]>>OCc1cccnc1Br",
        "output": "293"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cl[Co]Cl.N#Cc1ccccc1Cc1ccnc(Cl)n1.O=C([O-])O.[BH4-].[Na+].[Na+]>>NCc1ccccc1Cc1ccnc(Cl)n1",
        "output": "175"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.CSCCCl.Cc1nnc(-c2ccc3occ(-c4ccc(O)cc4)c3c2)o1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CSCCOc1ccc(-c2coc3ccc(-c4nnc(C)o4)cc23)cc1",
        "output": "74"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)cc(C(=O)O)cc2OCCO)c1.Nc1ccc2c(c1)OCO2>>COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)cc(C(=O)Nc3ccc4c(c3)OCO4)cc2OCCO)c1",
        "output": "817"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CC(=O)O.COc1cc2c(=O)cc[nH]c2cc1OCc1ccccc1>>COc1cc2c(=O)c(Br)c[nH]c2cc1OCc1ccccc1",
        "output": "292"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1[C@@H](C(=O)O)c1ccc(Cl)cc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.C[C@@H]1C[C@@H](O)c2ncnc(N3CCNCC3)c21.Cl.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@@H](c4ccc(Cl)cc4)[C@@H]4CCCN4C(=O)OC(C)(C)C)CC3)c21",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)C[AlH]CC(C)C.CCOC(=O)[C@@H]1C[C@H]1c1ccc2c(n1)n(C)c(=O)n2CC(C)(C)C>>Cn1c(=O)n(CC(C)(C)C)c2ccc([C@@H]3C[C@H]3CO)nc21",
        "output": "225"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCOc1cc(OCCCC2OCCO2)cc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)n(C)c(=O)n3C)c1.Cc1ccc(S(=O)(=O)O)cc1.O>>CCCOc1cc(OCCCC=O)cc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)n(C)c(=O)n3C)c1",
        "output": "740"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)C1(C)CCC(CO)CC1.Cl.[Na+].[OH-]>>CC1(C(=O)O)CCC(CO)CC1",
        "output": "361"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC[N+](CC)(CC)Cc1ccccc1.O=P(Cl)(Cl)Cl.O=c1[nH]cc(Br)c(O)c1[N+](=O)[O-].[Cl-]>>O=c1[nH]cc(Br)c(Cl)c1[N+](=O)[O-]",
        "output": "177"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CCO.O=C1Cc2ccccc2N1.O=Cc1ccc2[nH]nc(I)c2c1>>O=C1Nc2ccccc2C1=Cc1ccc2[nH]nc(I)c2c1",
        "output": "439"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NC1CCN(C(=O)c2c[nH]c3cc(Cl)ccc23)CC1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>NC1CCN(C(=O)c2c[nH]c3cc(Cl)ccc23)CC1",
        "output": "538"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)c1ccc(OCC(=O)OC(C)(C)C)cc1.CCCc1ccc(OCC(=O)O)cc1.ClCCl.O=C(O)C(F)(F)F>>CC(C)c1ccc(OCC(=O)O)cc1",
        "output": "278"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(c1ccc(C(=O)O)cc1Cl)C(O)(c1ccnc(Cl)c1)C(F)(F)F.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COC(=O)c1ccc(CN)cc1.Cl.F[P-](F)(F)(F)(F)F>>COC(=O)c1ccc(CNC(=O)c2ccc(C(C)C(O)(c3ccnc(Cl)c3)C(F)(F)F)c(Cl)c2)cc1",
        "output": "753"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCO.CCOC(C)=O.C[C@@H](N)C1CCC1.Cl.O=[N+]([O-])c1cc(C(F)(F)F)ccc1Cn1cnc2nc(Cl)nc(Cl)c21>>C[C@@H](Nc1nc(Cl)nc2ncn(Cc3ccc(C(F)(F)F)cc3[N+](=O)[O-])c12)C1CCC1",
        "output": "145"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCC=O.CCO.Cl.O=Cc1ccccc1.[K+].[OH-]>>CCC(C=O)=Cc1ccccc1",
        "output": "85"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.Cl.O=C([O-])O.O=C1N(Cc2ccc(Cl)cc2Cl)CCN1C1CCC2(CC1)OCCO2.[Na+]>>O=C1CCC(N2CCN(Cc3ccc(Cl)cc3Cl)C2=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCN(C(C)C)C(C)C.COC(=O)c1ccc(Cn2c3c(c4cc(F)ccc42)C(=O)N(CCO)CC3)cc1.CS(=O)(=O)Cl.OCCN1CCNCC1>>COC(=O)c1ccc(Cn2c3c(c4cc(F)ccc42)C(=O)N(CCN2CCN(CCO)CC2)CC3)cc1",
        "output": "371"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CC(C)(C)CC(O)C(=O)O.CO.O.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)(C)CC(O)C(=O)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)(C)c1ccc(C(=O)Cl)cc1.CS(=O)(=O)O.Cl.NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O>>CC(C)(C)c1ccc(C(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1",
        "output": "411"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)C(c1ccc(Cn2c(C)c(CC(C)C)sc2=O)cc1)C1CCCC1.Cl.[Na+].[OH-]>>Cc1c(CC(C)C)sc(=O)n1Cc1ccc(C(C(=O)O)C2CCCC2)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc(N)ccn1.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1cc(Cl)ccc1F>>COc1cc(NC(=O)c2cc(Cl)ccc2F)ccn1",
        "output": "50"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNC1.OCCCCl>>OCCCN1CCCC1",
        "output": "138"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(C)=O.FC(F)(F)c1cc(Cl)ncn1.NCc1ccc2[nH]c(C(F)(F)F)cc2c1.O.O=C([O-])[O-].[K+].[K+]>>FC(F)(F)c1cc(NCc2ccc3[nH]c(C(F)(F)F)cc3c2)ncn1",
        "output": "165"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCNc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)c(=O)n(CCN3CCN(C(=O)OC(C)(C)C)CC3)c2n1.CO.Cl.ClCCl>>CCNc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)c(=O)n(CCN3CCNCC3)c2n1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N.CCN(C(C)C)C(C)C.CCOC(C)O.Nc1ccc2ncn(-c3cncc(Cl)n3)c2c1>>CC(C)Nc1cncc(-n2cnc3ccc(N)cc32)n1",
        "output": "148"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCNCC1.CN(C)C=O.Nc1cc(Cl)ccc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>Nc1cc(N2CCCCC2)ccc1[N+](=O)[O-]",
        "output": "105"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C(O)(CC(=C(C)C)c1ccc(OC)c(F)c1)C(F)(F)F.CCOCC.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[Li+].[NH4+]>>COc1ccc(C(CC(O)(C=O)C(F)(F)F)=C(C)C)cc1F",
        "output": "260"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN.CCOC(=O)c1cnc2cc(OC)c(Br)cc2c1Nc1cccc(Cn2ccnc2)c1CC.Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>CCNc1cc2c(Nc3cccc(Cn4ccnc4)c3CC)c(C(=O)OCC)cnc2cc1OC",
        "output": "519"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)C(CC(=O)OC(C)(C)C)c1cccc2cnccc12.CO.O.O=P(O)(O)O.[Li+].[OH-]>>CC(C)(C)OC(=O)CC(C(=O)O)c1cccc2cnccc12",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1cc2cc[nH]c(=O)c2cc1Cl.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>Nc1cc2ccnc(Cl)c2cc1Cl",
        "output": "100"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)CCN(C1(C(=O)O)CCOCC1)S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl>>CCOC(=O)CCN(C1(C(=O)Cl)CCOCC1)S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1",
        "output": "56"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.C[Si](C)(C)Cl.Oc1ccc(-c2cccs2)cc1>>C[Si](C)(C)Oc1ccc(-c2cccs2)cc1",
        "output": "746"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)c1cccc(N)c1O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ccc2c(c1)CCC(COCc1ccccc1)O2.c1ccncc1>>CC(=O)c1cccc(NC(=O)c2ccc3c(c2)CCC(COCc2ccccc2)O3)c1O",
        "output": "50"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.C[C@H]1C[C@@H](N)CN1C(=O)OC(C)(C)C.ClCCl.O=S(=O)(Cl)c1cc(Br)c(F)cc1F>>C[C@H]1C[C@@H](NS(=O)(=O)c2cc(Br)c(F)cc2F)CN1C(=O)OC(C)(C)C",
        "output": "43"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCNc1ccc(Cl)cc1[N+](=O)[O-].N#Cc1ccc(S(=O)(=O)Cl)cc1.O.[H-].[Na+]>>CCN(c1ccc(Cl)cc1[N+](=O)[O-])S(=O)(=O)c1ccc(C#N)cc1",
        "output": "791"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)CCc1cc(OC)ccn1.[Na+].[OH-]>>COc1ccnc(CCC(=O)O)c1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.COc1ccccc1B(O)O.ClCCl.N#Cc1ccc(Br)s1.O.O=C([O-])[O-].[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccccc1-c1ccc(C#N)s1",
        "output": "864"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC1CCN(c2nc(C(F)(F)F)ccc2CN)CC1.CCN(CC)CC.CCN=C=NCCCN(C)C.CCS(=O)(=O)NCc1ccc(C(C)C(=O)O)cc1F.On1nnc2ccccc21>>CCS(=O)(=O)NCc1ccc(C(C)C(=O)NCc2ccc(C(F)(F)F)nc2N2CCC(C)CC2)cc1F",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.Clc1ccc(OC2CNC2)c(Cl)c1.Clc1ccnc(Cl)n1>>Clc1ccc(OC2CN(c3ccnc(Cl)n3)C2)c(Cl)c1",
        "output": "162"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CCOC(=O)Cc1cccc(O)c1.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)Cc1cccc(OCc2ccccc2)c1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.CN(C)CCO.Cc1cc(-c2cccc(-c3ccc(F)c(C)c3C)n2)c(C)[nH]1.N#N.O.[H-].[Na+]>>Cc1cc(-c2cccc(-c3ccc(OCCN(C)C)c(C)c3C)n2)c(C)[nH]1",
        "output": "485"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)O.CC(C)(C)OC(=O)N1CCC(c2ccc(N)cc2F)CC1.CCN(CC)CC.CO.ClCCCl.FC(F)(F)c1cnc(Cl)nc1Cl.[Cl-].[Cl-].[Zn+2]>>CC(C)(C)OC(=O)N1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(Cl)n3)cc2F)CC1",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)c1ccccn1.COc1c(Br)cnc(CO)c1C.ClCCl>>COc1c(Br)cnc(CO[Si](C)(C)C(C)(C)C)c1C",
        "output": "193"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N1CCN(C(=O)Cn2nc(-c3ccc(F)cc3)nc2-c2ccc(F)cc2)CC1.ClCCl>>O=C(Cn1nc(-c2ccc(F)cc2)nc1-c1ccc(F)cc1)N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CCOc1ccc(C=O)cc1[N+](=O)[O-].CO.Cl.[BH4-].[Na+]>>C=CCOc1ccc(CO)cc1[N+](=O)[O-]",
        "output": "356"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCOC(C)=O.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1cccc(-n2cnc3cc(-c4ccoc4)cnc32)c1.c1ccncc1>>O=S(=O)(Oc1cccc(-n2cnc3cc(-c4ccoc4)cnc32)c1)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)O.CN(C)C=O.COC(=O)CCN.Cl>>COC(=O)CCNC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)OC(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)N=C=O.CCOC(C)=O.CN(C)C=O.O.O=C1O[C@@H](CO)[C@H](c2ccccc2)N1c1ccc(Oc2ccc(Cl)cc2)cc1>>CC(C)NC(=O)OC[C@@H]1OC(=O)N(c2ccc(Oc3ccc(Cl)cc3)cc2)[C@H]1c1ccccc1",
        "output": "235"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1ccc(COC(=O)NNC(=O)c2cnccn2)cc1.Nc1ccccc1C(=O)O.O.[Na+].[OH-]>>CC(C)(C)OC(=O)Nc1ccccc1C(=O)O",
        "output": "735"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CC(C(=O)O)C1.CCN(C(C)C)C(C)C.CCN=C=N.CCOCC.CNOC.Cl.Cl.ClCCl.On1nnc2ccccc21>>CON(C)C(=O)C1CN(C(=O)OC(C)(C)C)C1",
        "output": "54"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)Cn1c(=O)ccn(CC(=O)OCc2ccccc2)c1=O.CCOC(C)=O.[OH-].[OH-].[Pd+2]>>CC(C)(C)OC(=O)Cn1c(=O)ccn(CC(=O)O)c1=O",
        "output": "186"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCCCNCCc1ccccc1Br.CCN(CC)CC.COC(=O)Cl.O>>CCCCCN(CCc1ccccc1Br)C(=O)OC",
        "output": "219"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc2c(c1)CC(C)(C)C(c1ccccc1NS(=O)(=O)c1ccccc1F)N2.[Na+].[OH-]>>CC1(C)Cc2cc(C(=O)O)ccc2NC1c1ccccc1NS(=O)(=O)c1ccccc1F",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)(C)C(=O)C(=Cc1ccc(Cl)cc1)n1cncn1.CO.O.[BH4-].[Na+]>>CC(C)(C)C(O)C(=Cc1ccc(Cl)cc1)n1cncn1",
        "output": "288"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCOc1ccc(Nc2cc(NC3CCCN(Cc4ccccc4)C3)nn3ccnc23)cc1.CO.NC1CCCN(Cc2ccccc2)C1.O=C(O)C(F)(F)F.[Pd]>>CCOc1ccc(Nc2cc(NC3CCCNC3)nn3ccnc23)cc1",
        "output": "84"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CI.O=C([O-])[O-].Oc1ccc(CCCI)cc1.[K+].[K+]>>COc1ccc(CCCI)cc1",
        "output": "62"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCCOC.N#Cc1cccc(B(O)O)c1.NC1=N[C@@]2(CCc3ccc(Br)cc32)C(F)(F)CO1.O>>N#Cc1cccc(-c2ccc3c(c2)[C@@]2(CC3)N=C(N)OCC2(F)F)c1",
        "output": "908"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCNCCCC(O)c1ccc(NS(C)(=O)=O)cc1.ICCCCCC1CC1.O=C([O-])O.[Na+]>>CCN(CCCCCC1CC1)CCCC(O)c1ccc(NS(C)(=O)=O)cc1",
        "output": "184"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.ClCCl.NCCNCC1COc2ccccc2O1.O=C(Cl)C(=O)Cl.O=C(O)C12CC3CC(CC(C3)C1)C2>>O=C(NCCNCC1COc2ccccc2O1)C12CC3CC(CC(C3)C1)C2",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NC(C(=O)O)C(C)(C)C.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)C(N)C1CCCCC1.ClCCl.F[P-](F)(F)(F)(F)F>>COC(=O)C(NC(=O)C(NC(=O)OC(C)(C)C)C(C)(C)C)C1CCCCC1",
        "output": "129"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.CNc1cc(Oc2cccc(NC(=O)OC(C)(C)C)c2)ccc1[N+](=O)[O-].[C].[H][H].[Pd]>>CNc1cc(Oc2cccc(NC(=O)OC(C)(C)C)c2)ccc1N",
        "output": "335"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.O=C(O)CN1C(=O)C(N[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)O)CCCc2ccccc21.[Pd]>>NCCCC[C@H](NC1CCCc2ccccc2N(CC(=O)O)C1=O)C(=O)O",
        "output": "574"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.O=[N+]([O-])c1ccc(CO)cc1C(F)(F)F>>O=Cc1ccc([N+](=O)[O-])c(C(F)(F)F)c1",
        "output": "179"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CC(=O)Cl.CCN(CC)CC.ClCCl.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCC2(CC1)CNC2>>C=CC(=O)N1CC2(CCC(n3nc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)C1",
        "output": "135"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)CN(C(=O)c1nc2ccccc2n1CCO)[C@H]1C[C@@H](C(=O)N2CCOCC2)CN(C(=O)OC(C)(C)C)C1.CCN(CC)CC.CS(=O)(=O)Cl.O=C([O-])O.[Na+]>>CC(C)CN(C(=O)c1nc2ccccc2n1CCOS(C)(=O)=O)[C@H]1C[C@@H](C(=O)N2CCOCC2)CN(C(=O)OC(C)(C)C)C1",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCC[C@H](NC(=O)N[C@H](CC(=O)O)c1ccc2c(c1)OCO2)C(=O)N(Cc1cccs1)Cc1cccs1.CI.CN(C)C=O.O.O=C([O-])[O-].[Na+].[Na+]>>CCCC[C@H](NC(=O)N[C@H](CC(=O)OC)c1ccc2c(c1)OCO2)C(=O)N(Cc1cccs1)Cc1cccs1",
        "output": "415"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C(O)C1CNCCO1.CS(=O)(=O)Cl.Cc1ccc(S(=O)(=O)Cl)cc1.Cl>>CCOC(=O)C(O)C1CN(S(=O)(=O)c2ccc(C)cc2)CCO1",
        "output": "99"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.Cc1c(CN2CCNCC2)sc2c(N3CCOCC3)nc(Cl)nc12.ClCCl.O=S(=O)(Cl)C1CC1>>Cc1c(CN2CCN(S(=O)(=O)C3CC3)CC2)sc2c(N3CCOCC3)nc(Cl)nc12",
        "output": "584"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCCCC1CN.Clc1cnccn1>>CC(C)(C)OC(=O)N1CCCCC1CNc1cnccn1",
        "output": "148"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)C(C)(C)Oc1ccc(CN2CN(c3ccccc3)C3(CCN(C(=O)OCc4ccccc4)CC3)C2=O)cc1.CCOC(C)=O.CO.[Pd]>>CC(C)(C)OC(=O)C(C)(C)Oc1ccc(CN2CN(c3ccccc3)C3(CCNCC3)C2=O)cc1",
        "output": "428"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCCCC.Cc1nc(Cl)c([N+](=O)[O-])c(NCC(C)(C)N)c1C.[Na+].[OH-]>>Cc1nc(Cl)c([N+](=O)[O-])c(NCC(C)(C)NC(=O)OC(C)(C)C)c1C",
        "output": "631"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1CCC(Oc2cccc3ncnc(Nc4ccc(Sc5ncc[nH]5)c(Cl)c4)c23)CC1.COCCBr>>COCCn1ccnc1Sc1ccc(Nc2ncnc3cccc(OC4CCN(C)CC4)c23)cc1Cl",
        "output": "495"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc2c(Oc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCc1ccccc1.[Pd]>>COc1cc2c(Oc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1O",
        "output": "23"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)COc1cccc2c1CCC[C@H]2NS(=O)(=O)c1ccc(-c2ccccc2Cl)cc1.[Li+].[OH-]>>O=C(O)COc1cccc2c1CCC[C@H]2NS(=O)(=O)c1ccc(-c2ccccc2Cl)cc1",
        "output": "278"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.CN(C)c1ccncc1.N#CCCNC1CC1>>CC(C)(C)OC(=O)N(CCC#N)C1CC1",
        "output": "694"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.NC(=O)c1ccc(Oc2ccc(C=O)cc2F)cn1.NCCN1CCSCC1.[BH4-].[Na+]>>NC(=O)c1ccc(Oc2ccc(CNCCN3CCSCC3)cc2F)cn1",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H]1C(=O)NCc1ccc2c(N)nccc2c1.ClCCl.O=C(O)C(F)(F)F>>Nc1nccc2cc(CNC(=O)[C@@H]3CCN3)ccc12",
        "output": "634"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.C[C@H](N)c1cc2cc(Cl)ccc2[nH]c1=O.Cc1nc(F)ccc1C#N.Cl.O>>Cc1nc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N",
        "output": "810"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.COc1cc2c(c(OC(C)=O)c1)[C@H]1CC[C@]3(C)[C@@H](O)CC[C@H]3[C@@H]1CC2.O.c1ccncc1>>COc1cc2c(c(OC(C)=O)c1)[C@H]1CC[C@]3(C)[C@@H](OC(C)=O)CC[C@H]3[C@@H]1CC2",
        "output": "254"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.CCOCC.O=S(=O)(O)O.Oc1cccc(Br)c1>>CC(=O)Oc1cccc(Br)c1",
        "output": "46"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(C)c1cc(Br)cc(Br)c1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCN(C(C)C)C(C)C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.SCc1ccccc1.[Pd].[Pd]>>CC(C)(C)c1cc(Br)cc(SCc2ccccc2)c1",
        "output": "824"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.CCN1c2c(Cl)cc(F)c(N)c2CS1(=O)=O.S=C(Cl)Cl>>CCN1c2c(Cl)cc(F)c(N=C=S)c2CS1(=O)=O",
        "output": "114"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CCO.CCOC(=O)c1cn(-c2ccc(F)cc2F)c2nc3c(F)c(N4CCN(c5ccc(F)cc5)CC4)c(F)cc3cc2c1=O.[K+].[OH-]>>O=C(O)c1cn(-c2ccc(F)cc2F)c2nc3c(F)c(N4CCN(c5ccc(F)cc5)CC4)c(F)cc3cc2c1=O",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)CC#N.NC1CC1>>N#CCC(=O)NC1CC1",
        "output": "392"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(CCCCCCCCc2ccccc2)cc1.[Na+].[OH-]>>O=C(O)c1ccc(CCCCCCCCc2ccccc2)cc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(CO)C1.CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)N1CCC(C=O)C1",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.O=C(O)c1c(-c2ccc(Cl)cc2)ccnc1Cl.O=S(Cl)Cl>>OCc1c(-c2ccc(Cl)cc2)ccnc1Cl",
        "output": "293"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CNC.O=C(Nc1ccc(CNc2nc(Cl)nc3ccc(I)cc23)cc1)c1ccc(F)cc1>>CN(C)c1nc(NCc2ccc(NC(=O)c3ccc(F)cc3)cc2)c2cc(I)ccc2n1",
        "output": "36"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.COc1c(F)cc(C(C)=O)cc1F.O>>CC(=O)c1cc(F)c(O)c(F)c1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN.CO.O=C1c2ccccc2C(=O)N1CCCCc1ccc(OCCO)cc1>>NCCCCc1ccc(OCCO)cc1",
        "output": "242"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.COC(=O)Cl.O=C([O-])[O-].O=C1CC2CNCC2C1.[K+].[K+]>>COC(=O)N1CC2CC(=O)CC2C1",
        "output": "219"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCNCC1.ClCCCl.ClCCl.O=Cc1c(Cl)cccc1N1CCCC1.[Na+]>>CC(C)(C)OC(=O)N1CCN(Cc2c(Cl)cccc2N2CCCC2)CC1",
        "output": "567"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O=P(Cl)(Cl)Cl.O=c1[nH]nccc1C(F)(F)F>>FC(F)(F)c1ccnnc1Cl",
        "output": "537"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cc1cccc(C)c1C(=O)O.O=S(Cl)Cl>>Cc1cccc(C)c1C(=O)Cl",
        "output": "3"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.COc1ccc(CO)c(OC)c1.Cl.O.O=C(O)[C@@H]1CCC[C@H]1C(=O)O.O=C([O-])O.[Na+]>>COc1ccc(COC(=O)[C@@H]2CCC[C@H]2C(=O)O)c(OC)c1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O=[Ag].OCCO.[I-].[K+]>>Cc1ccc(S(=O)(=O)OCCO)cc1",
        "output": "197"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CN(C)C=O.CO.O=C(O)C(F)(F)F.O=C1CCC(c2ccc(OC3CCNCC3)cc2)=NN1.O=C1CCC1.[BH3-]C#N.[Na+]>>O=C1CCC(c2ccc(OC3CCN(C4CCC4)CC3)cc2)=NN1",
        "output": "187"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1cc(C)c(C)cc1O.CN(C)c1ccncc1.COc1cc2c(Cl)ccnc2cc1OCc1ccccc1.Clc1ccccc1Cl>>COc1cc2c(Oc3cc(C)c(C)cc3C(C)=O)ccnc2cc1OCc1ccccc1",
        "output": "351"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CS(C)=O.O.O=Cc1ccc([N+](=O)[O-])cc1.OCC(F)(F)F.[Cl-].[H-].[Na+].[Na+]>>O=Cc1ccc(OCC(F)(F)F)cc1",
        "output": "499"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCOc1cccc(CC(OC(C)C)C(=O)OCC)c1.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Cc1ccccc1I.I[Cu]I>>CCOC(=O)C(Cc1cccc(OCC#Cc2ccccc2C)c1)OC(C)C",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCC1=NC2(Cc3ccc([N+](=O)[O-])cc3C2)C(=O)N1.CO.[Pd]>>CCCC1=NC2(Cc3ccc(N)cc3C2)C(=O)N1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCc1ccccc1.CC(C)Cc1nn(C)c(=O)c2c[nH]cc12.CN(C)C=O.Cl.[H-].[I-].[K+].[Na+]>>CC(C)Cc1nn(C)c(=O)c2cn(Cc3ccccc3)cc12",
        "output": "528"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.CN(C)C=O.N#CC(C(=O)Nc1cccc(N)c1)C(=O)c1nn(-c2ccccc2)c2c1Cc1ccccc1-2.c1ccncc1>>CC(=O)Nc1cccc(NC(=O)C(C#N)C(=O)c2nn(-c3ccccc3)c3c2Cc2ccccc2-3)c1",
        "output": "6"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)N(CC(=O)O)c2ccc3ncccc3c2)cc1.CCNCCO>>CCN(CCO)C(=O)CN(c1ccc2ncccc2c1)S(=O)(=O)c1ccc(C(C)(C)C)cc1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)C(C)(C)c1ccc([N+](=O)[O-])cc1.N#N.[Pd]>>CCOC(=O)C(C)(C)c1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)C(SC)c1cc(C=O)ccc1OC.Cl.[Na+].[OH-]>>COc1ccc(C=O)cc1C(SC)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc(-c2cccc(N)c2)c(OC)c1.F[P-](F)(F)(F)(F)F.O=C(O)c1cc2cccc(OC(F)(F)F)c2oc1=O>>COc1ccc(-c2cccc(NC(=O)c3cc4cccc(OC(F)(F)F)c4oc3=O)c2)c(OC)c1",
        "output": "799"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CC2(CCN1)OCCO2.CCN(CC)CC.CCOC(C)=O.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>O=[N+]([O-])c1ccc(S(=O)(=O)N2CCC3(CC2)OCCO3)cc1",
        "output": "99"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.COc1cc(C(=O)O)cc2c1ccn2C1CC1.NC(=O)c1nnc(-c2ccc3c(c2)C(=O)CC2(CCNCC2)O3)[nH]1.O.On1nnc2ccccc21>>COc1cc(C(=O)N2CCC3(CC2)CC(=O)c2cc(-c4nnc(C(N)=O)[nH]4)ccc2O3)cc2c1ccn2C1CC1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(O)CCl.COc1ccccc1N1CCNCC1.O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>COc1ccccc1N1CCN(CC(C)(C)O)CC1",
        "output": "138"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(O)(C(=O)Nc1ccc(S(=O)(=O)c2ccccc2)cc1[N+](=O)[O-])C(F)(F)F.CCOC(C)=O.CO.O.O=C[O-].[NH4+].[Pd]>>CC(O)(C(=O)Nc1ccc(S(=O)(=O)c2ccccc2)cc1N)C(F)(F)F",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.Cc1cc2nc(CC[C@H](NC(=O)OC(C)(C)C)C(=O)OCc3ccccc3)[nH]c2cc1C.Fc1cccc(CBr)c1.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1cc2nc(CC[C@H](NC(=O)OC(C)(C)C)C(=O)OCc3ccccc3)n(Cc3cccc(F)c3)c2cc1C",
        "output": "593"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.NCCO.O=C(Nc1cn(C2CCCCO2)nc1C(=O)O)c1ccccn1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>O=C(Nc1cn(C2CCCCO2)nc1C(=O)NCCO)c1ccccn1",
        "output": "816"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC[SiH](CC)CC.ClCCl.O=C(O)C(F)(F)F.O=C1Nc2cccc(Cl)c2C1(O)c1cc2c(cc1O)OCO2>>O=C1Nc2cccc(Cl)c2C1c1cc2c(cc1O)OCO2",
        "output": "964"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CNCCc1ccc(OC)c(OC)c1.C[C@@H](CBr)COCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>COc1ccc(CCN(C)C[C@H](C)COCc2ccccc2)cc1OC",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCC.Cc1cccc2nc(CO)c(-c3cccc(F)c3)c(=O)n12.Cc1ccccc1.[Mn+4].[O-2].[O-2]>>Cc1cccc2nc(C=O)c(-c3cccc(F)c3)c(=O)n12",
        "output": "263"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN.CO.COC(=O)CCc1c(-c2ccccc2)n(C)c(=O)c2ccccc12.ClCCl>>CNC(=O)CCc1c(-c2ccccc2)n(C)c(=O)c2ccccc12",
        "output": "392"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(CC=O)(C(=O)C1CCCCC1)c1ccccc1.COC(C)(C)C.COc1ccccc1N1CCNCC1.Cl.Cl.ClCCl.O.[Na+]>>COc1ccccc1N1CCN(CCC(C)(C(=O)C2CCCCC2)c2ccccc2)CC1",
        "output": "484"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(O)C(=O)O.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.C[C@H]1[C@H](Nc2c(C(N)=O)cnn3cc(Br)cc23)C[C@@H]2CNC[C@@H]21.O=C(O)C(F)(F)F>>C[C@H]1[C@H](Nc2c(C(N)=O)cnn3cc(Br)cc23)C[C@@H]2CN(C(=O)C(C)(C)O)C[C@@H]21",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(NC(CCC(F)(F)F)c2ccc(-n3cc4c(n3)CCCC4)cc2C)cc1.Cl.[Na+].[OH-]>>Cc1cc(-n2cc3c(n2)CCCC3)ccc1C(CCC(F)(F)F)Nc1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.Cc1cc(C=O)ccc1O.Cc1ccccc1.Cc1oc(-c2ccccc2)nc1CCOS(C)(=O)=O.O=S(=O)([O-])O.[K+].[OH-]>>Cc1cc(C=O)ccc1OCCc1nc(-c2ccccc2)oc1C",
        "output": "702"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN.O=Cc1cccc(O)c1>>CCNCc1cccc(O)c1",
        "output": "468"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.Cc1ccc2c(N3CCN(C(=O)OCc4ccccc4)CC3CO)nc(-c3ccccc3O)nc2c1.[Pd]>>Cc1ccc2c(N3CCNCC3CO)nc(-c3ccccc3O)nc2c1",
        "output": "428"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCCCCCCCCCNc1ccc(C#N)cc1.CN(C)C=O.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>CCCCCCCCCCCCCCCCNc1ccc(-c2nnn[nH]2)cc1",
        "output": "390"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cl.O=C(O)Cc1cccc(OCCCN(Cc2cccc(C(F)(F)F)c2Cl)CC(c2ccccc2)c2ccccc2)c1>>COC(=O)Cc1cccc(OCCCN(Cc2cccc(C(F)(F)F)c2Cl)CC(c2ccccc2)c2ccccc2)c1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(O)Cn1ccc(N)n1.CN(C)C=O.Cc1cccc(C)n1.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)[C@H](CC1CCCC1)c1ccc(S(=O)(=O)C2CC2)cc1>>CC(C)(O)Cn1ccc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(=O)(=O)C3CC3)cc2)n1",
        "output": "795"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cc1cc(C(=O)N2CCN(Cc3ccccc3)CC2CC(=O)O)c(-c2ccccc2)n1-c1ccccc1.Cl.Nc1ccccc1N.O=C([O-])O.On1nnc2ccccc21.[Na+]>>Cc1cc(C(=O)N2CCN(Cc3ccccc3)CC2CC(=O)Nc2ccccc2N)c(-c2ccccc2)n1-c1ccccc1",
        "output": "365"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.Cc1ccc(NC(=O)c2ccccc2[N+](=O)[O-])nc1.[BH4-].[Na+]>>Cc1ccc(NC(=O)c2ccccc2N)nc1",
        "output": "486"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(C)=O.ClCCCBr.O=C([O-])[O-].O=C(c1ccc(O)cc1)C1CC1.[K+].[K+]>>O=C(c1ccc(OCCCCl)cc1)C1CC1",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)C(C)(C)CCc1ncc(-c2ccc(NC(=NC#N)Nc3ccccc3F)cc2)s1.O=C(O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1>>CC(C)(CCc1ncc(-c2ccc(NC(=NC#N)Nc3ccccc3F)cc2)s1)C(=O)O",
        "output": "361"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc(OC)nc(Cl)n1.O=Cc1cccc(B(O)O)c1>>COc1cc(OC)nc(-c2cccc(C=O)c2)n1",
        "output": "874"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)CN(Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)cc1)S(=O)(=O)N1CCCc2ccccc21.O.[Li+].[OH-]>>Cc1oc(-c2ccccc2)nc1CCOc1ccc(CN(CC(=O)O)S(=O)(=O)N2CCCc3ccccc32)cc1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1[NH2+]CC12COC2.C1[NH2+]CC12COC2.Cc1onc(-c2ccc(F)cc2)c1/C=C/c1cc(C(=O)O)n(C)n1.O=C([O-])C(=O)[O-]>>Cc1onc(-c2ccc(F)cc2)c1/C=C/c1cc(C(=O)N2CC3(COC3)C2)n(C)n1",
        "output": "663"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)Cc1ccc(Cc2cc(C(F)(F)F)nc(C3CCCC3)n2)cc1.[Li+].[OH-]>>O=C(O)Cc1ccc(Cc2cc(C(F)(F)F)nc(C3CCCC3)n2)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Cn1c(CN2CCC(N3CCOCC3)CC2)nc2c(N3CCOCC3)nc(-c3cn(S(=O)(=O)c4ccccc4)c4ccccc34)nc21.[Na+].[OH-]>>Cn1c(CN2CCC(N3CCOCC3)CC2)nc2c(N3CCOCC3)nc(-c3c[nH]c4ccccc34)nc21",
        "output": "771"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.Nc1ccc(-c2c[nH]c3cc(F)ccc23)cn1>>CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc(-c2c[nH]c3cc(F)ccc23)cn1",
        "output": "368"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Br.Br.CC(=O)O.CCOCC.N#CCc1cccc(-c2nc(Nc3ccc(N4CCN(C(=O)OCc5ccccc5)CC4)cc3)nc3[nH]ccc23)c1.O=C=O>>N#CCc1cccc(-c2nc(Nc3ccc(N4CCNCC4)cc3)nc3[nH]ccc23)c1",
        "output": "428"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=C(Nc1ccc(CN2CCN(C(=O)OCc3ccccc3)CC2)cn1)c1cccc2[nH]c(-c3ccccc3C(F)(F)F)nc12.[Pd]>>O=C(Nc1ccc(CN2CCNCC2)cn1)c1cccc2[nH]c(-c3ccccc3C(F)(F)F)nc12",
        "output": "428"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)CCc1cnc(CC2CC(c3cccc(OC)c3OC)c3cc(Cl)ccc3-n3c(C(C)C)nnc32)s1.Cl.O.O=C([O-])[O-].[K+].[K+]>>COc1cccc(C2CC(Cc3ncc(CCC(=O)O)s3)c3nnc(C(C)C)n3-c3ccc(Cl)cc32)c1OC",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCN1CCNCC1.ClCCCl.ClCCl.Nc1ccc(C(=O)O)c(C(F)(F)F)c1.On1nnc2ccccc21>>CCN1CCN(C(=O)c2ccc(N)cc2C(F)(F)F)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClCCl.NC(CO)(CO)CO.O=C(Nc1ccc2c(c1)NCCC2)c1ccc(-c2ccccc2)cc1.[N-]=C=O>>CC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc21",
        "output": "160"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CC[C@H]2CN[C@H]2C1.CCN(C(C)C)C(C)C.FC(F)(F)c1ccnc(Cl)n1.O>>CC(C)(C)OC(=O)N1CC[C@H]2CN(c3nccc(C(F)(F)F)n3)[C@H]2C1",
        "output": "36"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC1(CCO)OCCc2c1[nH]c1c(Br)cc(C(C)C)cc21.O=Cc1cccc(B(O)O)c1>>CCC1(CCO)OCCc2c1[nH]c1c(-c3cccc(C=O)c3)cc(C(C)C)cc21",
        "output": "833"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)CC(C)C.CC1(C)NC(=O)C2CNCCN21.Fc1ccc(C(CCCCl)c2ccc(F)cc2)cc1.O.O=C([O-])[O-].[I-].[K+].[Na+].[Na+]>>CC1(C)NC(=O)C2CN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CCN21",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCNCC1.Nc1cc(Cl)ccc1[N+](=O)[O-].[Na+].[OH-]>>CN1CCN(c2ccc([N+](=O)[O-])c(N)c2)CC1",
        "output": "105"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCI.CN(C)C=O.O=[N+]([O-])c1cccc2[nH]ncc12.[H-].[Na+]>>CCn1ncc2c([N+](=O)[O-])cccc21",
        "output": "346"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.O=C(O)c1ccc(Cl)cc1O>>OCc1ccc(Cl)cc1O",
        "output": "72"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc2c(c1)NC(=O)C2.O=Cc1[nH]cc2c1CCOC2=O>>COc1ccc2c(c1)NC(=O)C2=Cc1[nH]cc2c1CCOC2=O",
        "output": "440"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.COC(=O)C(C)(C)c1ccc(Br)cc1.Cl.O.[Cl-].[Li+].[Na+].[OH-]>>CC(C)(C(=O)O)c1ccc(Br)cc1",
        "output": "203"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CN(C)Cc1cccc(OCCCN)c1.CN=C=O>>CNC(=O)NCCCOc1cccc(CN(C)C)c1",
        "output": "244"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CC(=O)N(C)C.CCN(C(C)C)C(C)C.COc1cc(F)ccc1[N+](=O)[O-].O>>COc1cc(N2CCOCC2)ccc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N1CCOc2ccc(-c3ccc(N)c([N+](=O)[O-])c3)cc2C1.CCOC(C)=O.[Pd]>>CC(C)(C)OC(=O)N1CCOc2ccc(-c3ccc(N)c(N)c3)cc2C1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1=CCCCC1.CCO.O=C(O)c1cc(N2CCOCC2)ccc1[N+](=O)[O-].[Pd]>>Nc1ccc(N2CCOCC2)cc1C(=O)O",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COCC(NC(=O)c1cc(Cl)ncn1)c1ccc(OC(F)(F)F)cc1.COc1ccc(CO)c(OC)c1.O.[H-].[Na+]>>COCC(NC(=O)c1cc(OCc2ccc(OC)cc2OC)ncn1)c1ccc(OC(F)(F)F)cc1",
        "output": "653"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(CC)CBr.CN(C)C=O.Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)[nH]ccc2c1.O=C([O-])[O-].[K+].[K+]>>CCC(CC)Cn1ccc2cc(-c3cc(C(=O)NC4CC4)ccc3C)ccc2c1=O",
        "output": "470"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1sc(C2CCCN(C(=O)OC(C)(C)C)C2)nc1-c1ccc(Oc2ccccc2)cc1.O.[Li+].[OH-]>>CC(C)(C)OC(=O)N1CCCC(c2nc(-c3ccc(Oc4ccccc4)cc3)c(C(=O)O)s2)C1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.NCCCc1ccccc1>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)NCCCc1ccccc1",
        "output": "216"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc2c(Oc3ccc4[nH]c(C)c(C)c4c3)ncnc2cc1O.OCCN1CCOCC1>>COc1cc2c(Oc3ccc4[nH]c(C)c(C)c4c3)ncnc2cc1OCCN1CCOCC1",
        "output": "478"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CN(C)CC(=O)O.COc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)ccc1Nc1nc(Cl)cc2cn[nH]c(=O)c12.O=C([O-])[O-].Oc1cccc(Cl)c1Cl.[Cs+].[Cs+]>>COc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)ccc1Nc1nc(Oc2cccc(Cl)c2Cl)cc2cn[nH]c(=O)c12",
        "output": "516"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCC#N.CNC(=O)CN1CCC(Oc2cc(C#N)ccc2OC)CC1.N.O.O=S(=O)(O)O.O=[N+]([O-])O.O=[N+]([O-])O>>CNC(=O)CN1CCC(Oc2cc(C#N)c([N+](=O)[O-])cc2OC)CC1",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCCCC1.CC(=O)O.Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1.O.O=C1OC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "475"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[N-]=[N+]=NC1(CCO)c2cc(Br)ccc2Oc2c1cc(Cl)nc2F>>NC1(CCO)c2cc(Br)ccc2Oc2c1cc(Cl)nc2F",
        "output": "562"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cc2cc(F)cc(Cl)c2[nH]1.CO.Cl.[Na+].[OH-]>>O=C(O)c1cc2cc(F)cc(Cl)c2[nH]1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CCOC(C)=O.CN(C)C=O.Cl.O=C(O)CCCCCCCCCCC(=O)O.O=C([O-])[O-].[K+].[K+]>>O=C(O)CCCCCCCCCCC(=O)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Nc1ccc(Br)cc1F.CNCCNC.Cc1ccccc1.N.[C-]#N.[Cu]I.[Na+]>>CC(=O)Nc1ccc(C#N)cc1F",
        "output": "65"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)Cn1ccc2ccc(Cl)cc21.O=C([O-])O.O=S(=O)(Nc1nccs1)c1ccc(C2(O)CCNCC2)cc1.[Na+]>>O=C(Cn1ccc2ccc(Cl)cc21)N1CCC(O)(c2ccc(S(=O)(=O)Nc3nccs3)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(O)Cn1cc(-c2ccc3c(c2)OCCc2sc(-c4ncnn4C4CCN(CCO[Si](C)(C)C(C)(C)C)CC4)nc2-3)cn1.CO.Cl>>CC(C)(O)Cn1cc(-c2ccc3c(c2)OCCc2sc(-c4ncnn4C4CCN(CCO)CC4)nc2-3)cn1",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F.O=c1ccc2ccc(O)cc2o1.[H-].[Na+]>>O=c1ccc2ccc(OS(=O)(=O)C(F)(F)F)cc2o1",
        "output": "843"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CC(=O)Cl.Cc1cccc(C)n1.Cl.ClCCl.O=c1[nH]nc(-c2cc3cccc(F)c3c(N[C@H]3CCNC3)n2)[nH]1>>C=CC(=O)N1CC[C@H](Nc2nc(-c3n[nH]c(=O)[nH]3)cc3cccc(F)c23)C1",
        "output": "135"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCCCC1.CCCc1nc(CC)c2c(=O)[nH]c(-c3cc(S(=O)(=O)Cl)ccc3OCC)nn12.CCOC(C)=O.COCCNCCOC>>CCCc1nc(CC)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N(CCOC)CCOC)ccc3OCC)nn12",
        "output": "99"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cc1cc(C=O)ccc1OCc1c(C)cccc1-n1nnn(C)c1=O.O.[BH4-].[Na+]>>Cc1cc(CO)ccc1OCc1c(C)cccc1-n1nnn(C)c1=O",
        "output": "356"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Nc1ccc(C(=O)O)c(O)c1.O=S(=O)(O)O>>COC(=O)c1ccc(N)cc1O",
        "output": "33"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1cccc(-n2ncc(NC(N)=NCC(F)(F)F)n2)c1.NCCO>>NC(=NCC(F)(F)F)Nc1cnn(-c2cccc(C(=O)NCCO)c2)n1",
        "output": "338"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CC(=O)N(C)c1c(I)c(N)c(I)c(C(=O)O)c1I>>CC(=O)N(C)c1c(I)c(N)c(I)c(C(=O)N2CCOCC2)c1I",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)[C@@]1(F)[C@@H]2C[C@@H](O)[C@@](N=[N+]=[N-])(C(=O)OCc3ccccc3)[C@@H]21.CCOC(C)=O.O=C(Cl)c1ccc(Cl)c(Cl)c1.c1ccncc1>>CCOC(=O)[C@@]1(F)[C@@H]2C[C@@H](OC(=O)c3ccc(Cl)c(Cl)c3)[C@@](N=[N+]=[N-])(C(=O)OCc3ccccc3)[C@@H]21",
        "output": "51"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)[C@H]1CCC[C@@H](c2cc(F)c(F)c(F)c2)N1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OC[C@H]1CCC[C@@H](c2cc(F)c(F)c(F)c2)N1",
        "output": "430"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)CC(C[N+](=O)[O-])c1cccc(Cl)c1.[Ni]>>CCOC(=O)CC(CN)c1cccc(Cl)c1",
        "output": "226"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1ncc2c(cc(-c3ccccc3)c(=O)n2Cc2nccs2)c1O.C[O-].NCCC(=O)O.[Na+]>>O=C(O)CCNC(=O)c1ncc2c(cc(-c3ccccc3)c(=O)n2Cc2nccs2)c1O",
        "output": "487"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)CO.CC(=O)O[BH-](OC(C)=O)OC(C)=O.NC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C1.[Na+]>>CC(CO)NC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C1",
        "output": "236"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.Cc1c(Cl)cnc2[nH]c(-c3ccc(O)c([N+](=O)[O-])c3)nc12.Cl.ClCCN1CCOCC1.[H-].[Na+]>>Cc1c(Cl)cnc2[nH]c(-c3ccc(OCCN4CCOCC4)c([N+](=O)[O-])c3)nc12",
        "output": "74"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.Cc1c(COc2cc(O)c(C=O)cc2Br)cccc1-c1ccccc1.N#Cc1cncc(CCl)c1.O.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1c(COc2cc(OCc3cncc(C#N)c3)c(C=O)cc2Br)cccc1-c1ccccc1",
        "output": "678"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.COCCOCCOCCOCCCC(=O)O.Cl.ClCCl.O=C1CCC(=O)N1O>>COCCOCCOCCOCCCC(=O)ON1C(=O)CCC1=O",
        "output": "303"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C1CNCCNC1.Cl.O=S(=O)(Cl)c1cccc2cnccc12>>O=S(=O)(c1cccc2cnccc12)N1CCCNCC1",
        "output": "99"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.NC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C1.O=CC1CCCC1.[Na+]>>O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CC(NCC2CCCC2)C1",
        "output": "426"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCCCCCCCCCCCN1C[C@@H](Oc2ccc(I)cc2)C[C@H]1C(=O)OC.[H-]>>CCCCCCCCCCCCN1C[C@@H](Oc2ccc(I)cc2)C[C@H]1CO",
        "output": "430"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc2oc(-c3cc(N)ccc3Cl)nc2c1.Cc1ccccc1C(=O)Cl>>Cc1ccc2oc(-c3cc(NC(=O)c4ccccc4C)ccc3Cl)nc2c1",
        "output": "11"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)C(=O)Cl.CCN(CC)CC.CN(C)CC1CCC2CC2C1(O)c1cc(O)cc(F)c1.ClCCl>>CN(C)CC1CCC2CC2C1(O)c1cc(F)cc(OC(=O)C(C)(C)C)c1",
        "output": "111"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Fc1cc(C(F)(F)F)cnc1N1CCC(NC2CC2)CC1.O=C(O)c1ccc(-n2cncn2)cc1>>O=C(c1ccc(-n2cncn2)cc1)N(C1CC1)C1CCN(c2ncc(C(F)(F)F)cc2F)CC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.COC(=O)c1ccc(OCC2CCCN2)cn1.COc1cc(CC(=O)O)ccc1NC(=O)Nc1ccccc1Br.Cl>>COC(=O)c1ccc(OCC2CCCN2C(=O)Cc2ccc(NC(=O)Nc3ccccc3Br)c(OC)c2)cn1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C)=O.CCCCCCCCC(=O)Cl.O=[N+]([O-])c1cc(CO)cc([N+](=O)[O-])c1.c1ccncc1>>CCCCCCCCC(=O)OCc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1",
        "output": "126"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N1CC(C)(C)c2ccc([N+](=O)[O-])cc21.CCO.[Pd]>>CC(=O)N1CC(C)(C)c2ccc(N)cc21",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.ClC(Cl)Cl.NCC1CCOC1.O=C(O)c1cc(Cc2ccc3ccccc3c2)on1.On1nnc2ccccc21>>O=C(NCC1CCOC1)c1cc(Cc2ccc3ccccc3c2)on1",
        "output": "696"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COC(=O)c1cnc(Cl)cn1.[Cl-].[Li+]>>O=C(O)c1cnc(Cl)cn1",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCl.O=[Mn]=O.O=[N+]([O-])c1cccc(-c2cccnc2CO)c1>>O=Cc1ncccc1-c1cccc([N+](=O)[O-])c1",
        "output": "263"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.COc1ccc(C(CCN(C(C)C)C(C)C)(C(N)=O)c2ccccn2)cc1.ClCCl>>CC(C)N(CCC(C(N)=O)(c1ccc(O)cc1)c1ccccn1)C(C)C",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OCc1ccc(Cl)nc1Cl.CO.[Na+].[OH-]>>OCc1ccc(Cl)nc1Cl",
        "output": "348"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)/C=C/c1ccc(Cl)cc1-c1ccccc1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)/C=C/c1ccc(Cl)cc1-c1ccccc1",
        "output": "158"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc2c(-c3ccccc3OC)n[nH]c(=O)c2c1.O=P(Cl)(Cl)Cl>>COc1ccc2c(-c3ccccc3OC)nnc(Cl)c2c1",
        "output": "537"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CS(=O)(=O)Cl.Nc1ncnn2c(C3CCNCC3)cc(-c3ccc4cn(-c5ccccc5)nc4c3)c12>>CS(=O)(=O)N1CCC(c2cc(-c3ccc4cn(-c5ccccc5)nc4c3)c3c(N)ncnn23)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)COCc1cnc(-c2cc3cccc(N(C)S(=O)(=O)c4cccs4)c3[nH]2)s1.CO.[Na+].[OH-]>>CN(c1cccc2cc(-c3ncc(COCC(=O)O)s3)[nH]c12)S(=O)(=O)c1cccs1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)CCN.Cl.O=C(O)c1ccc(Br)cc1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CN(C)CCNC(=O)c1ccc(Br)cc1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCI.CCOC(C)=O.O.O=C([O-])[O-].OC1(c2cc(F)cc(Cl)c2)CNC1.[K+].[K+]>>CCN1CC(O)(c2cc(F)cc(Cl)c2)C1",
        "output": "184"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)N=NC(=O)OCC.CCOCCO.COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2ccc(O)cc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOCCOc1ccc(C(=O)c2c(-c3ccc(OC)cc3)sc3cc(OC)ccc23)cc1",
        "output": "550"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CCCCO.C1CCNCC1.FC(F)(F)Oc1ccc(I)cc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>OCCCC#Cc1ccc(OC(F)(F)F)cc1",
        "output": "664"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.O.[N-]=[N+]=NC[C@H]1CN(c2ccc(I)cc2)C(=O)O1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NC[C@H]1CN(c2ccc(I)cc2)C(=O)O1",
        "output": "89"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CNCCN(C)C.N#Cc1ccc(Cl)c(C(F)(F)F)c1>>CN(C)CCN(C)c1ccc(C#N)cc1C(F)(F)F",
        "output": "105"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)c1ccncc1.COc1cc(CC(=O)c2ccc3c(c2)C(O)CC(C)(C)O3)cc(OC)c1OC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O>>COc1cc(CC(=O)c2ccc3c(c2)C(OS(=O)(=O)c2ccc(C)cc2)CC(C)(C)O3)cc(OC)c1OC",
        "output": "197"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CCOC(=O)N1c2cc(OCCCC(=O)OC)c(OC)cc2CN2CCC[C@H]2[C@@H]1OC1CCCCO1.CO.O.[Na+].[OH-]>>C=CCOC(=O)N1c2cc(OCCCC(=O)O)c(OC)cc2CN2CCC[C@H]2[C@@H]1OC1CCCCO1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(C)O.CN(CC(=O)OC(C)(C)C)C[C@@H]1CC(c2ccc(-c3ccc(N4C[C@H](Cn5ccnn5)OC4=O)cc3F)cn2)=NO1.Cl.O>>CN(CC(=O)O)C[C@@H]1CC(c2ccc(-c3ccc(N4C[C@H](Cn5ccnn5)OC4=O)cc3F)cn2)=NO1",
        "output": "278"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCc1ncc(C(=O)O)[nH]1.C[C@@H](N)Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1>>C[C@H](Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1)NC(=O)c1cnc(CNC(=O)OC(C)(C)C)[nH]1",
        "output": "697"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1ccc(N2C(=S)N(c3cnc(C#N)c(C(F)(F)F)c3)C(=O)C23CCC3)cc1F.CO.Cl.[Na+].[OH-]>>N#Cc1ncc(N2C(=O)C3(CCC3)N(c3ccc(C(=O)O)c(F)c3)C2=S)cc1C(F)(F)F",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "N#CCc1ccc(N=C=O)cc1.OCc1cccnc1.c1ccccc1>>N#CCc1ccc(NC(=O)OCc2cccnc2)cc1",
        "output": "34"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(O)C(=O)O.CCN=C=NCCCN(C)C.CN1CCOCC1.C[C@@H](O)c1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CNC3)n(C)c2n1.ClCCl.On1nnc2ccccc21>>C[C@@H](O)c1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CN(C(=O)C(C)(C)O)C3)n(C)c2n1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#C[Si](C)(C)C.CCNCC.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Ic1cccc([C@@H]2CN3CCC[C@H]3c3cc(OCCCN4CCCCC4)ccc32)c1.[Cu]I.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C[Si](C)(C)C#Cc1cccc([C@@H]2CN3CCC[C@H]3c3cc(OCCCN4CCCCC4)ccc32)c1",
        "output": "826"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCc2onc(C(=O)O)c2C1.NCC1CC1>>CC(C)(C)OC(=O)N1CCc2onc(C(=O)NCC3CC3)c2C1",
        "output": "696"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)CBr.CN(C)C=O.OCc1cccnc1.[H-].[Na+]>>CC(C)(C)OC(=O)COCc1cccnc1",
        "output": "669"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.Cc1ccc(C#N)cc1Br.[Li]CCCC>>Cc1ccc(C#N)cc1B(O)O",
        "output": "832"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.CCO.Clc1cc(N2CCNCC2)cc(Cl)c1Cl>>CC(=O)N1CCN(c2cc(Cl)c(Cl)c(Cl)c2)CC1",
        "output": "369"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(NC(=O)OCc1ccccc1)c1nc2cccnn2c1-c1ccccn1.CSC.O=C(O)C(F)(F)F>>CC(N)c1nc2cccnn2c1-c1ccccn1",
        "output": "574"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1ccc2c(c1)CCN(C1CCNCC1)C(=O)N2.Cc1cc(C(=O)c2cc(Cl)nnc2Cl)cc2oc(=O)[nH]c12.O.O=CO>>COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)c4cc(C)c5[nH]c(=O)oc5c4)c(Cl)nn3)CC1)C(=O)N2",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CCc1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cn1.[Li+].[OH-]>>O=C(O)CCc1ccc(-c2c(/C=C/c3ccc4ccccc4n3)nc3c(N4CCOCC4)ccnn23)cn1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCSc1ccc(F)cc1N.Cl.O=N[O-].[Na+].[Na+].[OH-]>>CCSc1ccc(F)cc1NN",
        "output": "109"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CNC(=O)c1ccc2c(c1)CCO[C@H]2CCOS(C)(=O)=O.C[C@@H]1CN(c2cccc3cc(C#N)ccc23)CCN1>>CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(c2cccc3cc(C#N)ccc23)C[C@H]1C",
        "output": "496"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCN1.C=CC(=O)Cl.CCC(C)=O.CCN(CC)CC.COc1ccc(O)cc1>>C=CC(=O)N1CCOCC1",
        "output": "135"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CCOC(C)=O.CO.Cl.Nc1ccc2[nH]nnc2c1.O=C1c2ccccc2C(=O)C1(O)O.O=Cc1ccc2ccccc2c1.[BH3-]C#N.[Na+].[Na+].[OH-]>>c1ccc2cc(CNc3ccc4[nH]nnc4c3)ccc2c1",
        "output": "359"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1ccc(N=C=O)cc1.NCCCN1Cc2ccccc2CC1Cc1ccc(F)cc1>>CCc1ccc(NC(=O)NCCCN2Cc3ccccc3CC2Cc2ccc(F)cc2)cc1",
        "output": "35"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cc(C)c(Br)cn1.COc1ccc(B(O)O)cc1>>COc1ccc(-c2cnc(OC)cc2C)cc1",
        "output": "833"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCBr.Fc1ccc(CBr)cc1.O=C1Nc2ccccc2C12COc1cc3c(cc12)OCCO3.O=C1Nc2ccccc2[C@]12COc1cc3c(cc12)OCCO3>>O=C1N(Cc2ccc(F)cc2)c2ccccc2C12COc1cc3c(cc12)OCCO3",
        "output": "688"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)CCc1cccc(CO[Si](C)(C)C(C)(C)C)n1.[Na+].[OH-]>>CC(C)(C)[Si](C)(C)OCc1cccc(CCC(=O)O)n1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)CCC(C)(C)c2cc(C=O)c(C#C[Si](C)(C)C)cc21.CO.O.O=C([O-])[O-].[K+].[K+]>>C#Cc1cc2c(cc1C=O)C(C)(C)CCC2(C)C",
        "output": "337"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC1C(C)CC(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CC1NC(=O)OC(C)(C)C.CO.O=C([O-])[O-].[K+].[K+]>>CC1CC(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CC(NC(=O)OC(C)(C)C)C1O",
        "output": "325"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NCCCc1nc2c(OCc3ccc(CNC(=O)C(F)(F)F)cc3)nc(N)nc2[nH]1.CCOCC.ClCCl.O=C(O)C(F)(F)F>>NCCCc1nc2c(OCc3ccc(CNC(=O)C(F)(F)F)cc3)nc(N)nc2[nH]1",
        "output": "538"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(C(C)C)C(C)C.CN(C)C=O.CS(C)=O.Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCNCC3)nc2)c1.O.O=C(O)c1cnc2ccc(F)cc2c1.[NH4+].[OH-]>>Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2ccc(NC3CCN(C(=O)c4cnc5ccc(F)cc5c4)CC3)nc2)c1",
        "output": "256"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.Cc1onc2c1c(=O)n(C1CCCC(CNC(=O)c3ccccc3)C1)c1cccc(N)c21>>CC(=O)Nc1cccc2c1c1noc(C)c1c(=O)n2C1CCCC(CNC(=O)c2ccccc2)C1",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.CO.Cl.Fc1ccc(C2CCC3(CC2)OCCO3)cc1.O>>O=C1CCC(c2ccc(F)cc2)CC1",
        "output": "251"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)c1ccncc1.COc1cc2nccc(Cl)c2cc1OC.Cc1ccc(O)c(Cl)c1.Clc1ccccc1Cl.O>>COc1cc2nccc(Oc3ccc(C)cc3Cl)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NCCC(=O)O.CCN1CCOCC1.CN(C)C=O.Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCNC2.ClCCCl.O.O=C(O)C(F)(F)F.O=C([O-])O.On1nnc2ccccc21.[Na+]>>Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(C(=O)CCNC(=O)OC(C)(C)C)C2",
        "output": "633"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CNc1cc(Cl)ncc1CO.ClCCl.[Mn+4].[O-2].[O-2]>>CNc1cc(Cl)ncc1C=O",
        "output": "520"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.NCCc1ccc(C(CCCCC(=O)O)c2cccnc2)cc1.O=C([O-])[O-].O=S(=O)(Cl)c1ccc(Cl)cc1.[K+].[K+]>>O=C(O)CCCCC(c1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1)c1cccnc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCN1CCC(=C(c2ccc(C(=O)N(CC)CC)cc2)c2ccccc2NC(=O)OC)CC1.CCN(CC)C(=O)c1ccc(C(=C2CCN(Cc3ccccn3)CC2)c2ccccc2N)cc1.COC(=O)Cl.[Zn]>>CCN(CC)C(=O)c1ccc(C(=C2CCN(Cc3ccccn3)CC2)c2ccccc2NC(=O)OC)cc1",
        "output": "102"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1cc(F)cc(Cl)c1.ClCCl.O=C([O-])O.[Na+]>>Oc1cc(F)cc(Cl)c1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.OCc1ccc2[nH]ncc2n1>>O=Cc1ccc2[nH]ncc2n1",
        "output": "263"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cl.FC(F)(F)c1ccc2c(Cl)ccnc2c1.Nc1ccccc1C(=O)O>>O=C(O)c1ccccc1Nc1ccnc2cc(C(F)(F)F)ccc12",
        "output": "115"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COc1cc(Br)cc(C(=O)O)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1cc(Br)cc(CO)c1",
        "output": "72"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C(CCc1ccccc1)n1cnc(C(N)=O)c1.CO.O.[BH4-].[Na+]>>NC(=O)c1cn(C(CO)CCc2ccccc2)cn1",
        "output": "225"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "N.N#CCC(COCc1ccccc1)COCc1ccccc1.[H][H].[Ni]>>NCCC(COCc1ccccc1)COCc1ccccc1",
        "output": "246"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.Cl.Clc1cccc(Nc2cc(Cl)ncn2)c1.NC1CCCCC1>>Clc1cccc(Nc2cc(NC3CCCCC3)ncn2)c1",
        "output": "166"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)C1CCN(CCn2cccc(-c3ccc(C(=O)OCc4ccccc4)cc3)c2=O)CC1.[H][H].[Pd]>>CCOC(=O)C1CCN(CCn2cccc(-c3ccc(C(=O)O)cc3)c2=O)CC1",
        "output": "290"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)c1ccc(N)cc1.COc1cn(C(C)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1OC(F)F>>COc1cn(C(C)C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)cc1-c1cc(Cl)ccc1OC(F)F",
        "output": "710"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccccc1.Clc1cc2ccc(Br)cc2c(Cl)n1.OCc1ccccc1>>Clc1cc2ccc(Br)cc2c(OCc2ccccc2)n1",
        "output": "433"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CN(C)c1ccc2cc3c(c(-c4ccc(CO)cc4)c2c1)C(=O)CC3.ClCCl>>CN(C)c1ccc2cc3c(c(-c4ccc(C=O)cc4)c2c1)C(=O)CC3",
        "output": "179"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC(C)Sc1ccc(OCCN)cc1.CCOC(=O)Cl.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)NCCOc1ccc(SC(C)CC)cc1",
        "output": "94"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C(=O)O)(c1ccccc1)c1ccccc1.CCOCC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC(CO)(c1ccccc1)c1ccccc1",
        "output": "231"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(NS(=O)(=O)c1ccc(-c2cccc(CN)c2)cc1)c1cnn[nH]1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Cl.O.O=Cc1ccccc1.[Na+]>>CC(C)(NS(=O)(=O)c1ccc(-c2cccc(CNCc3ccccc3)c2)cc1)c1cnn[nH]1",
        "output": "683"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc(F)c2[nH]ncc2c1)c1ccncc1Cl.ClCCl.O=C(OO)c1cccc(Cl)c1>>CC/C(=C(/c1ccc(/C=C/C(=O)O)cc1)c1cc(F)c2[nH]ncc2c1)c1cc[n+]([O-])cc1Cl",
        "output": "262"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)CCC(C)(C)c2cc(O)ccc21.CCC(C)=O.CN(C)C=O.N#Cc1ccc(CCl)cc1.O.O=C([O-])[O-].[K+].[K+]>>CC1(C)CCC(C)(C)c2cc(OCc3ccc(C#N)cc3)ccc21",
        "output": "49"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.O=C([O-])O.O=Cc1cc2ccccc2[nH]c1=O.[Na+].[Na+].c1cc(CCC2CCNCC2)c2c(c1)OCO2>>O=c1[nH]c2ccccc2cc1CN1CCC(CCc2cccc3c2OCO3)CC1",
        "output": "757"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.N#CCC1(n2cc(-c3cnn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)CNC1.O=CC1CC1.[Na+]>>N#CCC1(n2cc(-c3cnn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)CN(CC2CC2)C1",
        "output": "484"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)O/N=C(/c1cccc(Br)c1)c1ncccc1O.O=C(OO)c1cccc(Cl)c1.O=S([O-])[O-].[Na+].[Na+]>>CC(C)(C)O/N=C(/c1cccc(Br)c1)c1c(O)ccc[n+]1[O-]",
        "output": "262"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.CN[C@H](CN1CC[C@H](O[Si](C)(C)C(C)(C)C)C1)c1cccc(C#N)c1.ClCCl.O=C(O)Cc1ccc2c(c1)NC(=O)CS2(=O)=O.On1nnc2ccccc21>>CN(C(=O)Cc1ccc2c(c1)NC(=O)CS2(=O)=O)[C@H](CN1CC[C@H](O[Si](C)(C)C(C)(C)C)C1)c1cccc(C#N)c1",
        "output": "633"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.C[O-].O=C(O)C1Cc2ccccc2N1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+]>>OCC1Cc2ccccc2N1",
        "output": "218"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "N=C(NO)c1ccccc1F.O=C(O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)N2CCC(O)CC2)C1>>O=C(N1CCC(O)CC1)N1CC(c2ccc(OC(F)(F)F)cc2)CC(c2nc(-c3ccccc3F)no2)C1",
        "output": "895"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClCCl.O=S(Cl)Cl.OCc1cc2cccc(Cl)c2nc1-c1ccccc1C(F)(F)F>>FC(F)(F)c1ccccc1-c1nc2c(Cl)cccc2cc1CCl",
        "output": "477"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc(Nc2cc(C(F)(F)F)cc(Cl)n2)ccc1-n1cnc(C)c1.Nc1ccc(C(F)(F)F)cc1>>COc1cc(Nc2cc(C(F)(F)F)cc(Nc3ccc(C(F)(F)F)cc3)n2)ccc1-n1cnc(C)c1",
        "output": "434"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2cc(-c3ccc(OCc4c(COc5c(C)cccc5C)noc4C(C)C)cc3)ccc2n1.Cl.[Na+].[OH-]>>Cc1cccc(C)c1OCc1noc(C(C)C)c1COc1ccc(-c2ccc3nc(C(=O)O)ccc3c2)cc1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCCCCC1(C(=O)Cl)CCc2ccccc2C1.CN(C)c1ccncc1.COc1cc(OC)c(N)c(OC)c1.ClCCl>>CCCCCCCCCC1(C(=O)Nc2c(OC)cc(OC)cc2OC)CCc2ccccc2C1",
        "output": "134"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCO.CCOC(=O)CCCn1cc(C(=O)c2ccc(OC(CCN3CCN(c4ccccc4OC)CC3)c3ccccc3)cc2)c2ccccc21.[K+].[OH-]>>COc1ccccc1N1CCN(CCC(Oc2ccc(C(=O)c3cn(CCCC(=O)O)c4ccccc34)cc2)c2ccccc2)CC1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=S(=O)(Nc1cncc(Br)c1)c1ccccc1.[K+]>>CC1(C)OB(c2cncc(NS(=O)(=O)c3ccccc3)c2)OC1(C)C",
        "output": "943"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CC(=O)Nc1cc(F)cc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3OC)nc3c2c(Cl)cn3COCC[Si](C)(C)C)c1.ClCCl.O=C(O)C(F)(F)F>>C=CC(=O)Nc1cc(F)cc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3OC)nc3[nH]cc(Cl)c23)c1",
        "output": "897"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN(C)C=O.COCCBr.COc1cc(C=O)ccc1O.O=C([O-])[O-].[K+].[K+]>>COCCOc1ccc(C=O)cc1OC",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.COc1ccc2c(c1)cc1n2CCNC1.ClCCl.O=C(CCl)N1CCN(C2CCC2)CC1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>COc1ccc2c(c1)cc1n2CCN(CC(=O)N2CCN(C3CCC3)CC2)C1",
        "output": "340"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCP(CCCC)CCCC.CCNC(=O)c1ccc(-n2nnc(C(=O)NC3CC3)c2CCCO)cc1.Cc1ccccc1.O=C(/N=N/C(=O)N1CCCCC1)N1CCCCC1.Oc1ccc(OC(F)(F)F)cc1>>CCNC(=O)c1ccc(-n2nnc(C(=O)NC3CC3)c2CCCOc2ccc(OC(F)(F)F)cc2)cc1",
        "output": "478"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNC1.CO.C[C@@H]1CCCN1CCN1CCc2cc(Oc3ccc(C(=O)O)cc3)ccc2C1=O>>C[C@@H]1CCCN1CCN1CCc2cc(Oc3ccc(C(=O)N4CCCC4)cc3)ccc2C1=O",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CC(CCOc1c(F)c(F)c(F)c(F)c1F)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)NC.[Li+].[OH-]>>CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C(CCOc1c(F)c(F)c(F)c(F)c1F)CC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)N(CCc1ccccc1)Cc1c(C)noc1-c1ccc(Br)cc1.CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4CN(CCc4ccccc4)C(C)=O)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCC#Cc1ccc(C=O)cc1.NCc1ccc(Br)cc1>>CCCCCCC#Cc1ccc(CNCc2ccc(Br)cc2)cc1",
        "output": "683"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1cccc(Br)c1.CS(=O)(=O)c1ccc(-c2cn[nH]c(=O)c2Oc2ccc(F)cc2)cc1.N>>CS(=O)(=O)c1ccc(-c2cnn(-c3cccc(Br)c3)c(=O)c2Oc2ccc(F)cc2)cc1",
        "output": "919"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.O.O=C(Cc1c2c(nn1-c1ccccc1)c(Cl)nc1ccccc12)N1CCN(Cc2ccccc2)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>Clc1nc2ccccc2c2c(CCN3CCN(Cc4ccccc4)CC3)n(-c3ccccc3)nc12",
        "output": "112"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COCCOC.Nc1ccc(-c2csc3c(-c4ccncc4)cnc(N)c23)cc1.O.O=C=Nc1cc(C(F)(F)F)ccc1F>>Nc1ncc(-c2ccncc2)c2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12",
        "output": "473"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(CO)CC1.CC(C)OC(=O)N=NC(=O)OC(C)C.O=[N+]([O-])c1ccc(O)cc1F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCC(COc2ccc([N+](=O)[O-])c(F)c2)CC1",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CCN.CCOC(C)=O.CN(C)C=O.ClCCCl.Nc1ncc(-c2ccc(C(=O)O)cc2)cc1OCc1c(Cl)cccc1Cl.On1nnc2ccccc21>>CCN(CC)CCNC(=O)c1ccc(-c2cnc(N)c(OCc3c(Cl)cccc3Cl)c2)cc1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1cc(Oc2ccc(F)cc2F)ccc1[N+](=O)[O-].Cl.O.[Na+].[OH-]>>O=C(O)c1cc(Oc2ccc(F)cc2F)ccc1[N+](=O)[O-]",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCc2ncnc(Sc3cc(Nc4nc(CCc5ccccc5)cs4)ncc3Br)c2C1.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>Brc1cnc(Nc2nc(CCc3ccccc3)cs2)cc1Sc1ncnc2c1CNCC2",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCCN.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.O=C(O)C1CCN(c2nsc(N3CCN(C(=O)Nc4noc5ccccc45)CC3)n2)CC1.On1nnc2ccccc21>>CC(C)(C)OC(=O)NCCNC(=O)C1CCN(c2nsc(N3CCN(C(=O)Nc4noc5ccccc45)CC3)n2)CC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cl.O.O=C(O)CC(=O)O.O=Cc1cccc(Cl)c1.c1ccncc1>>O=C(O)C=Cc1cccc(Cl)c1",
        "output": "12"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cccc(C)n1.ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O[C@@H](c1ccc(Cl)nc1)C(F)(F)F>>O=S(=O)(O[C@@H](c1ccc(Cl)nc1)C(F)(F)F)C(F)(F)F",
        "output": "582"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COc1ccc(-c2nc3cc(OC)cc(OC)c3c(=O)[nH]2)c(F)c1.C[Si](C)(C)[N-][Si](C)(C)C.NC1CCN(Cc2ccccc2)CC1.[Li+]>>COc1ccc(-c2nc3cc(OC)cc(OC)c3c(=O)[nH]2)c(NC2CCN(Cc3ccccc3)CC2)c1",
        "output": "572"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cncc(-c3ccc(F)cc3F)c2)CC1.CCOC(C)=O.CCOC(C)=O.Cl>>Fc1ccc(-c2cncc(N3CCNCC3)c2)c(F)c1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCc1c2c(c(C(C)(C)C)c(OC(C)=O)c1C(C)(C)C)CC(C)(C)O2.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCc1c2c(c(C(C)(C)C)c(O)c1C(C)(C)C)CC(C)(C)O2",
        "output": "22"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCCCCCCn1nnc(C(=NOC)C(=O)OCC)n1.CCO.[Na+].[OH-]>>CCCCCCCCCCCCn1nnc(C(=NOC)C(=O)O)n1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)NC1CCN(c2cc(C#N)cc(N)c2Cl)CC1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.COc1ccc(CN(c2nc(Cl)nn3c(C#N)cnc23)C2CC2)cc1.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].[Pd+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1ccc(CN(c2nc(Nc3cc(C#N)cc(N4CCC(NC(=O)OC(C)(C)C)CC4)c3Cl)nn3c(C#N)cnc23)C2CC2)cc1",
        "output": "990"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(C)=O.CCOCC.COC(=O)c1ccc(-c2[nH]c3c(Cl)ccc4c3c2CCC4N)cc1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NC1CCc2c(-c3ccc(CO)cc3)[nH]c3c(Cl)ccc1c23",
        "output": "444"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC=CCC(N)(CC)C(=O)OCC.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC=CCC(N)(CC)CO",
        "output": "225"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CCN(CC)CC.CCOCC.CN(C)c1ccccn1.Cl.O=C(Cl)c1ccc(NCCCCCCCCCCCCCCCCBr)cc1>>O=C(c1ccc(NCCCCCCCCCCCCCCCCBr)cc1)N1CCCCC1",
        "output": "201"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCNC1.O=C(O)CO>>Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)CO)C1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(=O)c1cccc(Sc2c(C)n(-c3cnn(CCO[Si](C)(C)C(C)(C)C)c3)c3c(F)c(Cl)ccc23)c1.[F-]>>CCOC(=O)c1cccc(Sc2c(C)n(-c3cnn(CCO)c3)c3c(F)c(Cl)ccc23)c1",
        "output": "708"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCC.CCOC(C)=O.CCS(=O)(=O)c1ccc(F)c(Br)c1.CS(C)=O.Cc1cccc(C=O)c1O.O=C([O-])[O-].[Cs+].[Cs+]>>CCS(=O)(=O)c1ccc(Oc2c(C)cccc2C=O)c(Br)c1",
        "output": "564"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C(=O)c1ccc2c(c1)OCO2)[C@H](CCN)Cc1ccccc1.Cl.ClCCCl.ClCCl.O=C(O)c1cc2ccccc2[nH]1.On1nnc2ccccc21>>CN(C(=O)c1ccc2c(c1)OCO2)[C@H](CCNC(=O)c1cc2ccccc2[nH]1)Cc1ccccc1",
        "output": "137"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.Cc1ccc2c(c1)N(CC(=O)c1cccs1)C(=O)C(NC(=O)OC(C)(C)C)CN2C(=O)C(C)(C)C.Cl>>Cc1ccc2c(c1)N(CC(=O)c1cccs1)C(=O)C(N)CN2C(=O)C(C)(C)C",
        "output": "431"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.COc1ccc2nc(-c3cccnc3)nc(Nc3ccccc3C(N)=O)c2c1.ClCCl.O=C([O-])O.[Na+]>>NC(=O)c1ccccc1Nc1nc(-c2cccnc2)nc2ccc(O)cc12",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CS(=O)(=O)Cc1cc(N2CCOCC2)nc(-c2ccc(N)cc2)n1.F[P-](F)(F)(F)(F)F.O=C(O)C1CCC1>>CS(=O)(=O)Cc1cc(N2CCOCC2)nc(-c2ccc(NC(=O)C3CCC3)cc2)n1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)Cc1cc2ccc(Cl)cc2c(-c2ccc(S(=O)(=O)c3ccccc3Cl)cc2)c1C.O.O.[Li+].[OH-]>>Cc1c(CC(=O)O)cc2ccc(Cl)cc2c1-c1ccc(S(=O)(=O)c2ccccc2Cl)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(N)c1ccccc1.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.O=C(Cl)c1ccccc1>>CC(C)(NC(=O)c1ccccc1)c1ccccc1",
        "output": "411"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)C=O.CO.O=C(Cl)C(=O)Cl.O=C(O)c1ccc2[nH]ncc2c1>>COC(=O)c1ccc2[nH]ncc2c1",
        "output": "195"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.NC1CCCCC1.O=C(CCl)Nc1n[nH]c2cc(Cl)ccc12>>O=C(CNC1CCCCC1)Nc1n[nH]c2cc(Cl)ccc12",
        "output": "330"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.COC(=O)c1cc(O)cc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccc(Br)cc2F)c1.ClCCl.[Na+].[OH-]>>Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(Br)cc2F)n1-c1cc(O)cc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(CN=[N+]=[N-])(C2CCCCC2)CC1.CCOC(C)=O.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCC(CN)(C2CCCCC2)CC1",
        "output": "89"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cl.N.Nc1c(Cl)cccc1C(=O)O.O.O.On1nnc2ccccc21>>NC(=O)c1cccc(Cl)c1N",
        "output": "358"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(B(O)O)cc1N.Fc1ccc(OCc2cn3cc(Br)cnc3n2)cc1>>Cc1ccc(-c2cnc3nc(COc4ccc(F)cc4)cn3c2)cc1N",
        "output": "871"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1nccc(Cl)c1I.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>Nc1ncc([N+](=O)[O-])c(Cl)c1I",
        "output": "328"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCc1nc2ccc(Br)cc2n1C.CNCCNC.CS(C)=O.I[Cu]I.N.O=C([O-])[O-].O=c1cc(OCc2ccc(F)cc2)cc[nH]1.[K+].[K+]>>CCc1nc2ccc(-n3ccc(OCc4ccc(F)cc4)cc3=O)cc2n1C",
        "output": "982"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCNc1nc(N)nc(C)c1Cc1ccc(O)cc1.CN(C)C=O.O.O=C([O-])[O-].OCCCBr.[Cs+].[Cs+].[I-].[Na+]>>CCCCCNc1nc(N)nc(C)c1Cc1ccc(OCCCO)cc1",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1c[nH]c2ccncc12.C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccccn1>>CC(C)(C)OC(=O)n1cc(Br)c2cnccc21",
        "output": "748"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCCCOC(=O)Cl.Cc1ccccc1.O.O=Cc1ccc(O)cc1.c1ccncc1>>CCCCCCCCOC(=O)Oc1ccc(C=O)cc1",
        "output": "261"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.CC(=O)O.CN(C)C=O.Cc1onc(-c2ccccc2)c1-c1c[nH]cn1.[H-].[Na+]>>Cc1onc(-c2ccccc2)c1-c1cn(Cc2ccccc2)cn1",
        "output": "593"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COCOc1ccc(OC)c(C=O)c1.Cl.O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(O)cc1C=O",
        "output": "755"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.COc1ccc(-c2cc3cc(F)c(F)cc3[nH]2)cc1NS(=O)(=O)c1cccc([N+](=O)[O-])c1.[Zn]>>COc1ccc(-c2cc3cc(F)c(F)cc3[nH]2)cc1NS(=O)(=O)c1cccc(N)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCNCCO.CCn1cc(-c2ccnc3c2cc(C=O)n3S(=O)(=O)c2ccccc2)c(-c2ccc([N+](=O)[O-])cc2)n1>>CCN(CCO)Cc1cc2c(-c3cn(CC)nc3-c3ccc([N+](=O)[O-])cc3)ccnc2n1S(=O)(=O)c1ccccc1",
        "output": "829"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.Cl.ClC(Cl)Cl.O.O=C(Nc1cnc(-c2cccc(O)c2)cn1)Oc1ccccc1.O=C1OC2(CCNCC2)c2ccccc21>>O=C1OC2(CCN(C(=O)Nc3cnc(-c4cccc(O)c4)cn3)CC2)c2ccccc21",
        "output": "525"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COCCOC.ClC(Cl)Cl.N#Cc1cc(Br)cc(-c2nc(-c3ccccn3)no2)c1.O=C([O-])[O-].OB(O)c1ccncc1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1cc(-c2ccncc2)cc(-c2nc(-c3ccccn3)no2)c1",
        "output": "904"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.O=[N+]([O-])c1c(CS(=O)(=O)c2cccc3ccccc23)cccc1OC(CCl)CCl.[Pd]>>Nc1c(CS(=O)(=O)c2cccc3ccccc23)cccc1OC(CCl)CCl",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.COc1cc(N)cnc1N1CCCC1.O.O=C(Cl)Oc1ccccc1.c1ccncc1>>COc1cc(NC(=O)Oc2ccccc2)cnc1N1CCCC1",
        "output": "763"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCc1nc2c(N)nc3ccccc3c2n1CCCNC(=O)OC(C)(C)C.CCO.Cl>>CCCCc1nc2c(N)nc3ccccc3c2n1CCCN",
        "output": "538"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc(-c2ocnc2C)cc1.[Na+].[OH-]>>Cc1ncoc1-c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.COc1ccccc1N1CCN(CC(O)COc2ccccc2CC(N)=O)CC1.[Na+].[OH-].c1ccncc1>>COc1ccccc1N1CCN(CC(COc2ccccc2CC(N)=O)OC(C)=O)CC1",
        "output": "254"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=C(O)c1ccc2ncccc2c1.O=S(=O)([O-])[O-]>>COC(=O)c1ccc2ncccc2c1",
        "output": "33"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N(CCCN1CCCCC1)c1nnc(-c2ccc([N+](=O)[O-])cc2)o1.CCO.[Pd]>>CC(C)(C)OC(=O)N(CCCN1CCCCC1)c1nnc(-c2ccc(N)cc2)o1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCC.Cc1ccc(N)c(C)n1.O=C(Cl)CCl.c1ccncc1>>Cc1ccc(NC(=O)CCl)c(C)n1",
        "output": "422"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCC(C(=O)OC)c1c(C)nc(N2CCCCC2)nc1-c1ccc(C)cc1.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc(N2CCCCC2)nc1-c1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NC1(CO[Si](C)(C)C(C)(C)C)CCN(c2cccnc2[N+](=O)[O-])CC1.[H][H].[Pd]>>CC(C)(C)OC(=O)NC1(CO[Si](C)(C)C(C)(C)C)CCN(c2cccnc2N)CC1",
        "output": "457"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCCCBr.CC(C)(C)OC(=O)n1nc(-c2cc3ccc(O)cc3n2C(=O)OC(C)(C)C)c2sc(-c3ccccc3)cc21.CCOC(C)=O.ClCCl.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)(C)OC(=O)n1nc(-c2cc3ccc(OCCCBr)cc3n2C(=O)OC(C)(C)C)c2sc(-c3ccccc3)cc21",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N1CC(C(=O)O)CC(c2ccc(CC(F)F)cc2)C1.COCCC(N)=NO>>COCCc1noc(C2CC(c3ccc(CC(F)F)cc3)CN(C(C)=O)C2)n1",
        "output": "728"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CNc1nc(Cl)ncc1F.COc1cc(C(=O)O)ccc1N.Cl>>CNc1nc(Nc2ccc(C(=O)O)cc2OC)ncc1F",
        "output": "808"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[O-].CN(C)C=O.Cc1cccc(-n2c(-c3ccc4ncnn4c3)c(C)[nH]c2=O)c1.Cc1cccc(CBr)c1.[K+]>>Cc1cccc(Cn2c(C)c(-c3ccc4ncnn4c3)n(-c3cccc(C)c3)c2=O)c1",
        "output": "593"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.Nc1cc(N2CCOCC2)n2nccc2n1.O=C(O)C1CC1.c1ccncc1>>O=C(Nc1cc(N2CCOCC2)n2nccc2n1)C1CC1",
        "output": "368"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCS(=O)(=O)Cl.CCN(CC)CC.CN(C)C=O.CS(=O)(=O)c1ccc(Nc2ncnc(OC3CCNCC3)c2[N+](=O)[O-])cc1>>CCCS(=O)(=O)N1CCC(Oc2ncnc(Nc3ccc(S(C)(=O)=O)cc3)c2[N+](=O)[O-])CC1",
        "output": "584"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COC(=O)Cc1ccc2oc(-c3c(C)noc3C)nc2c1.[Na+].[OH-]>>Cc1noc(C)c1-c1nc2cc(CC(=O)O)ccc2o1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.ClCCl.O=S(Cl)Cl.OCc1cccc(-c2cccc(Cl)c2)n1>>ClCc1cccc(-c2cccc(Cl)c2)n1",
        "output": "594"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)c1ccc(N=C=O)cc1.CCN(CC)CC.Cl.c1ccc(C2=NOC3(CCNC3)C2)cc1>>CC(C)(C)c1ccc(NC(=O)N2CCC3(CC(c4ccccc4)=NO3)C2)cc1",
        "output": "323"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOC(=O)C(Oc1ccc(C(C)O)cc1)c1ccccc1.CS(=O)(=O)Cl.ClCCl>>CCOC(=O)C(Oc1ccc(C(C)OS(C)(=O)=O)cc1)c1ccccc1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "B.C1CCOC1.C1CCOC1.CCCC1(CC(=O)OCC)OCCc2c1[nH]c1c(C)c(C(=O)O)cc(C#N)c21>>CCCC1(CC(=O)OCC)OCCc2c1[nH]c1c(C)c(CO)cc(C#N)c21",
        "output": "72"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1ccc(/C=C\\C(F)(F)F)cc1OC.[Na+].[OH-]>>COc1cc(/C=C\\C(F)(F)F)ccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.COc1cc(OC)c2[nH]ccc2c1CCN>>COc1cc(OC)c2[nH]ccc2c1CCNC(C)=O",
        "output": "339"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.CC(C)(C)[O-].CCOC(C)=O.Cl.NCc1ccccc1Oc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=c1[nH]nc(Cl)c2cc(Br)ccc12.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>O=c1[nH]nc(Cl)c2cc(NCc3ccccc3Oc3ccccc3)ccc12",
        "output": "932"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCCc1cccc(-c2ccc(C(N)=O)cc2)c1.ClC(Cl)Cl.ClCCl.O=C(O)C(F)(F)F.O=C([O-])[O-].[K+].[K+]>>NCCc1cccc(-c2ccc(C(N)=O)cc2)c1",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCn1c(=O)c2[nH]c(C34CCC(CCCC(=O)OC)(CC3)CC4)nc2n(CCC)c1=O.[Li+].[OH-]>>CCCn1c(=O)c2[nH]c(C34CCC(CCCC(=O)O)(CC3)CC4)nc2n(CCC)c1=O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1c(C(=O)O)c(-c2ccncc2)nn1-c1cccc(C(F)(F)F)c1.Cl.Cl.OC[C@@H]1CCCN1C1CCNCC1>>Cc1c(C(=O)N2CCC(N3CCC[C@H]3CO)CC2)c(-c2ccncc2)nn1-c1cccc(C(F)(F)F)c1",
        "output": "733"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(=O)c1ccc(OCCOc2ccc3ccccc3c2)s1.CO.[K+].[OH-]>>O=C(O)C(=O)c1ccc(OCCOc2ccc3ccccc3c2)s1",
        "output": "472"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O.CCN(CC)CC.Cl.ClCCl.N=C=N.NC[C@@H](O)CP(=O)(CC1CCCCC1)OCc1ccccc1.Oc1cccc2[nH]nnc12>>CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC[C@@H](O)CP(=O)(CC1CCCCC1)OCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CN(C2CN3CCC2CC3)CCN1.C1CN(C2CN3CCC2CC3)CCN1.CCN(C(C)C)C(C)C.Cc1cc(C)c(S(=O)(=O)Cl)c(C)c1.Cl.Cl.Cl.Cl.Cl.Cl.ClCCl.O>>Cc1cc(C)c(S(=O)(=O)N2CCN(C3CN4CCC3CC4)CC2)c(C)c1",
        "output": "99"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.COc1ccc2c(c1)OCCN2C(=O)c1cc(Cl)c(O)c(Cl)c1.ClCCl.O>>O=C(c1cc(Cl)c(O)c(Cl)c1)N1CCOc2cc(O)ccc21",
        "output": "402"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COC(=O)c1cc(C)c(NC(=O)c2nc(N3CCCC(CO[Si](C)(C)C(C)(C)C)C3)ccc2C)c(C)c1.[F-]>>COC(=O)c1cc(C)c(NC(=O)c2nc(N3CCCC(CO)C3)ccc2C)c(C)c1",
        "output": "708"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@H](Cc1ccccc1C(F)(F)F)C(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cl.ClCCl.NC1CCc2ccccc2NC1=O.O.On1nnc2ccccc21>>CC(C)(C)OC(=O)N[C@H](Cc1ccccc1C(F)(F)F)C(=O)NC1CCc2ccccc2NC1=O",
        "output": "133"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cn(C2CCN(C(=O)OC(C)(C)C)CC2)c(=O)[nH]1.O.O.[Li+].[OH-]>>CC(C)(C)OC(=O)N1CCC(n2cc(C(=O)O)[nH]c2=O)CC1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1ccc2nc(N3CCCCCC3)c(-c3ccccc3)nc2c1.Cl.[Na+].[OH-]>>O=C(O)c1ccc2nc(N3CCCCCC3)c(-c3ccccc3)nc2c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CCN(CC)CC.Cc1ccccc1.O=P(Cl)(Cl)Cl.O=c1[nH]cnc2ccc(I)cc12>>Clc1ncnc2ccc(I)cc12",
        "output": "14"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)CN.COc1ccc(N(CCCC(=O)O)C(=O)c2ccc(Cl)cc2)cc1>>CCOC(=O)CNC(=O)CCCN(C(=O)c1ccc(Cl)cc1)c1ccc(OC)cc1",
        "output": "107"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C)CC(=O)c2c([nH]c3c(Cl)cc(Cl)cc23)C1.CCOC(=O)CCCCCBr.CN(C)C=O.[H-].[Na+]>>CCOC(=O)CCCCCn1c2c(c3cc(Cl)cc(Cl)c31)C(=O)CC(C)(C)C2",
        "output": "470"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)O.CCN(CC)CC.Cl.Clc1ccncc1.N#Cc1ccc(OC2CCNCC2)nc1.O>>N#Cc1ccc(OC2CCN(c3ccncc3)CC2)nc1",
        "output": "398"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)N1c2ccc(C(F)(F)F)cc2C(C(N=[N+]=[N-])c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1CC.CCOC(C)=O.CO.[Pd]>>CCOC(=O)N1c2ccc(C(F)(F)F)cc2C(C(N)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1CC",
        "output": "562"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.CCN(C(C)C)C(C)C.CNCC(=O)NC(CCCc1ccccc1)CCCc1ccccc1.ClCCl.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CN(CC(=O)NC(CCCc1ccccc1)CCCc1ccccc1)C(=O)C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "297"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)c1cc2cc(F)ccc2oc1=O.Cl.O.[Na+].[OH-]>>O=C(O)c1cc2cc(F)ccc2oc1=O",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1nc(S(C)(=O)=O)nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c12.FC(F)(F)c1ccccc1.NCCO>>Cc1nc(NCCO)nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c12",
        "output": "629"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc3[nH]c(C(=O)O)c(-c4ccccc4)c3c2)cc1.CO.COCCN.ClCCl>>COCCNC(=O)c1[nH]c2ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)cc2c1-c1ccccc1",
        "output": "137"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CC2CC(O)CC2C1.CN(C)c1ccncc1.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)N1CC2CC(OS(C)(=O)=O)CC2C1",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.ClCCl.O=C1CCC(=O)N1Br.c1csc(-c2ccc(-c3cccs3)s2)c1>>Brc1ccc(-c2ccc(-c3cccs3)s2)s1",
        "output": "807"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1CC(=O)NN=C1c1ccc2nc(CCN)[nH]c2c1.OC1=Nc2cccc(OCC3CO3)c2CC1>>CC1CC(=O)NN=C1c1ccc2nc(CCNCC(O)COc3cccc4c3CCC(O)=N4)[nH]c2c1",
        "output": "16"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)c1cc2c(cn1)nnn2COCC[Si](C)(C)C.[BH4-].[Na+]>>C[Si](C)(C)CCOCn1nnc2cnc(CO)cc21",
        "output": "546"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOP(=O)(Cc1ccc(N)c(OC)c1)OCC.CNC(=O)c1ccccc1Nc1nc(Cl)ncc1C(F)(F)F>>CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccccc3C(=O)NC)n2)c(OC)c1)OCC",
        "output": "808"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(Cc1ccccc1)S(=O)(=O)c1ccc(OC)cc1.CO.[Na+].[OH-]>>COc1ccc(S(=O)(=O)C(Cc2ccccc2)C(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCN=C=NCCCN(C)C.Cl.NC(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1cccc(OCc2ccccc2)c1.O.O.O=C(O)c1cccc2c1C=CCCC2.On1nnc2ccccc21>>O=C(NC(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1cccc(OCc2ccccc2)c1)c1cccc2c1C=CCCC2",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CON(C)C(=O)c1n[nH]c2c1CNC(C)C2.ClCCl.O.O=C(Nc1cccc(Cl)c1)Oc1ccccc1>>CON(C)C(=O)c1n[nH]c2c1CN(C(=O)Nc1cccc(Cl)c1)C(C)C2",
        "output": "525"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NC12CC3CC(CC(C3)C1)C2.O=Cc1ccc(-c2ccn[nH]2)s1>>c1cc(-c2ccc(CNC34CC5CC(CC(C5)C3)C4)s2)[nH]n1",
        "output": "691"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)C(C)c1cc(C)n[nH]1.CO.O.[Na+].[OH-]>>Cc1cc(C(C)C(=O)O)[nH]n1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)CCC=C(C(=O)CCCCC=O)C1.Cc1ccccc1>>CC1(C)CCC=C(C(=O)CCCCCO)C1",
        "output": "223"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCOCC.CO.C[C@H]1CNC[C@@H](C)N1.O=C(Cl)COc1ccc(Cl)cc1>>C[C@H]1CN(C(=O)COc2ccc(Cl)cc2)C[C@@H](C)N1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.COc1cc(-c2c(N)ccc(Cl)c2F)ncn1.Cc1ccc(S(=O)(=O)O)cc1.O.O.O=N[O-].[I-].[Na+].[Na+]>>COc1cc(-c2c(I)ccc(Cl)c2F)ncn1",
        "output": "200"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCN(CC)CC.CCOC(C)=O.COC(=O)[C@@H](N)Cc1ccccc1.COC(=O)[C@@H](N)Cc1ccccc1.Cl.Cl.O=C(O)C[C@H](NC(=O)OCc1ccccc1)C(=O)O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].OCC(O)CO.[K+].[K+].[K+]>>COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)OCc1ccccc1",
        "output": "129"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.ClCCl.N#Cc1cc(C(=O)O)ccc1OCC1CC1.O=C(Cl)C(=O)Cl>>N#Cc1cc(C(=O)Cl)ccc1OCC1CC1",
        "output": "448"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.COc1ccc2cccc(C(CN)CO)c2c1.Cl.O.O=C(Cl)C1CC1.O=C([O-])[O-].[K+].[K+]>>COc1ccc2cccc(C(CO)CNC(=O)C3CC3)c2c1",
        "output": "45"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C=CCCNC.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=C(c1ccccc1)c1ccccc1.O=C=O.[Na]>>C=CCCN(C)C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.CCCCC1(CCCC)CN(c2ccc(Cl)cc2)c2cc(SC)c(OC)cc2S(=O)(=O)C1.ClCCl.NN.O.O>>CCCCC1(CCCC)CN(c2ccc(Cl)cc2)c2cc(SC)c(O)cc2S(=O)(=O)C1",
        "output": "402"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)S(=O)(=O)NC1CCCCC1O.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CC(C)S(=O)(=O)NC1CCCCC1=O",
        "output": "87"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)C1(c2ccc(Cl)c(Cl)c2)CCC1.CC(=O)[O-].Cl.NO.O.O.O.O.[Na+]>>CC(=NO)C1(c2ccc(Cl)c(Cl)c2)CCC1",
        "output": "86"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)O.CCN1CCc2ccc(N)cc2CC1.CNC(=O)CCNc1nc(Cl)ncc1Cl.Cl>>CCN1CCc2ccc(Nc3ncc(Cl)c(NCCC(=O)NC)n3)cc2CC1",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCNCCCC.CCN(C(C)C)C(C)C.CN(C)C=O.COc1ccc2c(c1)nc(C(=O)C(C)(C)C)n2CC(=O)O.ClCCCl.On1nnc2ccccc21>>CCCCN(CCCC)C(=O)Cn1c(C(=O)C(C)(C)C)nc2cc(OC)ccc21",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC1(CO)COC1.CCCCC.Nc1nccc(Cl)n1.O.[H-].[Na+]>>CC1(COc2ccnc(N)n2)COC1",
        "output": "653"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)O.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cc(CO)ccn1>>CC(C)(C)OC(=O)Nc1cc(CO)ccn1",
        "output": "849"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.O=C(CBr)c1ccccc1.O=C([O-])[O-].Oc1ccccc1Br.[K+].[K+]>>O=C(COc1ccccc1Br)c1ccccc1",
        "output": "221"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "B.C1CCOC1.C1CCOC1.COc1ccc2c(c1)CC(C(=O)O)CS2>>COc1ccc2c(c1)CC(CO)CS2",
        "output": "231"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#Cc1ccc(N)nc1N.C1CCOC1.CCN(CC)CC.O.ON=C(Cl)Cc1ccc(COc2ncccc2F)cc1>>Nc1ccc(-c2cc(Cc3ccc(COc4ncccc4F)cc3)no2)c(N)n1",
        "output": "976"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Oc1ccccc1C(=O)Cl.CCN(C(C)C)C(C)C.CCOC(=O)c1cc2cc(N)ccc2n1C.ClCCl>>CCOC(=O)c1cc2cc(NC(=O)c3ccccc3OC(C)=O)ccc2n1C",
        "output": "11"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CO.COC(=O)C1CCCC(NC(=O)OC(C)(C)C)C1.Cl>>COC(=O)C1CCCC(N)C1",
        "output": "538"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(B(O)O)cc1.Cc1cccnc1Br>>Cc1ccc(-c2ncccc2C)cc1",
        "output": "869"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1cnc2nc(COc3ccccn3)cn2c1.COc1cc(Cl)ccc1B(O)O>>COc1cc(Cl)ccc1-c1cnc2nc(COc3ccccn3)cn2c1",
        "output": "871"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.FC(F)c1ccc(Br)cc1.[K+]>>CC1(C)OB(c2ccc(C(F)F)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.CCN(CC)CC.Cc1cccc2c1CN[C@@H]1CN(Cc3ccccc3)C[C@@H]21.ClCCl>>CC(=O)N1Cc2c(C)cccc2[C@@H]2CN(Cc3ccccc3)C[C@H]21",
        "output": "240"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Nc1ccc2c(c1)nc(C(C)(C)C)n2CC1CCOCC1.Cl>>CC(C)(C)c1nc2cc(N)ccc2n1CC1CCOCC1",
        "output": "66"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1(S(=O)(=O)c2ccc(OC)cc2)CCN(C2CCCCCCC2)CC1.CO.[Na+].[OH-]>>COc1ccc(S(=O)(=O)C2(C(=O)O)CCN(C3CCCCCCC3)CC2)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COCCOCCOC.NCCCO.O.O=c1ccc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)cn1Cc1ccc(Cl)nc1>>O=c1ccc(-c2nc(-c3ccc(OC(F)(F)F)cc3)no2)cn1Cc1ccc(NCCCO)nc1",
        "output": "70"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=CC1(c2ccc(Cl)c(Cl)c2)CCCC1.OCC1(c2ccc(C(F)(F)F)cc2)CCCC1>>OCC1(c2ccc(Cl)c(Cl)c2)CCCC1",
        "output": "223"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(C)=O.CN(C)C=O.Cl.NC(=O)c1cc(C2CCNCC2)ccc1F.O=C([O-])[O-].O=P(Cl)(Cl)Cl.[Na+].[Na+]>>N#Cc1cc(C2CCNCC2)ccc1F",
        "output": "374"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.FC(F)(F)c1ccc(Oc2cccc(C=C3CCNCC3)c2)nc1.Nc1cnccn1.O=C(Nc1cnccn1)Oc1ccccc1>>O=C(Nc1cnccn1)N1CCC(=Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1",
        "output": "525"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc13.CN(C)C=O.ClCCCBr.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(OCCCCl)cc13",
        "output": "75"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2CCOCC2)c2ncnn12.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(C2CCOCC2)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cl.O=C(O)c1cccc(S)c1>>COC(=O)c1cccc(S)c1",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.CS(=O)(=O)c1nc(Cl)c2c(n1)CCC2.C[O-].[Na+]>>COc1nc(S(C)(=O)=O)nc2c1CCC2",
        "output": "461"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCCBr.COc1ccc(-c2ccc3c(c2)COC3=O)c(OC)c1O.O=C([O-])[O-].[K+].[K+]>>CCCOc1c(OC)ccc(-c2ccc3c(c2)COC3=O)c1OC",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1c(-c2cccnc2)n(CCCCCCO)c2ccccc12.ClCCl.O=[Cr](=O)=O.[Cr+6].[O-2].[O-2].[O-2].c1ccncc1.c1ccncc1.c1ccncc1>>Cc1c(-c2cccnc2)n(CCCCCC=O)c2ccccc12",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1nc(-c2cn(CCC3CC3)nn2)sc1C(=O)O.Cc1nc(-c2cn(Cc3ccccc3)nn2)sc1C(=O)O.NCc1cccnc1>>Cc1nc(-c2cn(CCC3CC3)nn2)sc1C(=O)NCc1cccnc1",
        "output": "534"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1cnc2ccccc2c1.C#CCCCCO.CCN(CC)CC.ClCCl.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1>>OCCCCC#Cc1cnc2ccccc2c1",
        "output": "719"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)C[AlH]CC(C)C.COC(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)nc1C>>Cc1nc(-c2ccc(C(F)(F)F)cc2)ccc1CO",
        "output": "522"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "O=C(O)c1ccccc1SCc1ccccc1.O=S(Cl)Cl.c1ccccc1>>O=C(Cl)c1ccccc1SCc1ccccc1",
        "output": "3"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.COc1cc([N+](=O)[O-])ccc1OCC(C)(C)O.C[Si](C)(C)CCOCCl.ClCCl.O>>COc1cc([N+](=O)[O-])ccc1OCC(C)(C)OCOCC[Si](C)(C)C",
        "output": "598"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CC(C)[Si](Cl)(C(C)C)C(C)C.COc1cc(C=O)c(F)cc1O.COc1cc(O)cc(C=O)c1>>COc1cc(C=O)c(F)cc1O[Si](C)(C)C(C)(C)C",
        "output": "746"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)C[C@@H](CN1CCNCC1)NC(=O)OC(C)(C)C.CCN(CC)CC.Cl.ClCCCl.ClCCl.O.O=C(N[C@@H](CO)C(=O)O)OCc1ccccc1.O=C([O-])O.On1nnc2ccccc21.[Cl-].[Na+].[Na+]>>CC(C)C[C@@H](CN1CCN(C(=O)[C@H](CO)NC(=O)OCc2ccccc2)CC1)NC(=O)OC(C)(C)C",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)c1cc(-c2ccccc2)n(S(=O)(=O)c2ccc(C)cc2)c1.Cc1ccccc1.Cl.[H-]>>Cc1ccc(S(=O)(=O)n2cc(CO)cc2-c2ccccc2)cc1",
        "output": "383"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CNC.Cl.ClCCl.O=S(=O)(Cl)CCCCl>>CN(C)S(=O)(=O)CCCCl",
        "output": "584"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCOC(C)=O.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1cccc(C)c1B(O)O.Cc1ccccc1.O.O=Cc1cccc(Br)c1O.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd+2]>>Cc1cccc(C)c1-c1cccc(C=O)c1O",
        "output": "837"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COc1ccc(C)cc1NC(=S)NC(=O)c1ccccc1.C[O-].[Na+]>>COc1ccc(C)cc1NC(N)=S",
        "output": "80"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.COC(=O)/C=C/c1ccc2c(c1)C(=O)CC1(CCCN(Cc3ccccc3)C1)O2.Cl>>O=C(O)/C=C/c1ccc2c(c1)C(=O)CC1(CCCN(Cc3ccccc3)C1)O2",
        "output": "58"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.CCn1c([C@@H](C)NS(=O)(=O)c2ccc(F)c(C#N)c2)nc2ccc(C(F)(F)F)cc21.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCn1c([C@@H](C)NS(=O)(=O)c2ccc(F)c(CN)c2)nc2ccc(C(F)(F)F)cc21",
        "output": "175"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCCCCCCC(=O)O.CO.O=S(=O)(O)O>>CCCCCCCCCCCCCCCC(=O)OC",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C(O)(c1cccc(Br)c1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.O=Cc1cccc(B(O)O)c1>>CC(C)C(O)(c1cccc(-c2cccc(C=O)c2)c1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1",
        "output": "837"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)[C@H]1COC(=O)N1c1ccn2ncc(-c3ccc(-c4ncn(CC(=O)OC(C)(C)C)n4)cc3)c2n1.ClCCl.O=C(O)C(F)(F)F>>CC(C)[C@H]1COC(=O)N1c1ccn2ncc(-c3ccc(-c4ncn(CC(=O)O)n4)cc3)c2n1",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)c1ccc(CNCC(F)c2ccc(Cl)cc2)cc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O.O=C(O)c1cc(Cl)cc2cc[nH]c12>>CC(C)(C)c1ccc(CN(CC(F)c2ccc(Cl)cc2)C(=O)c2cc(Cl)cc3cc[nH]c23)cc1",
        "output": "893"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CI.CN(C)C=O.O.[H-].[Na+].c1ccc(COc2ccc3[nH]ccc3c2)cc1>>Cn1ccc2cc(OCc3ccccc3)ccc21",
        "output": "191"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](C(=O)O)C1.CCN=C=NCCCN(C)C.CN1CCOCC1.CO.C[C@H]1CCCN1.Cl.ClCCl.On1nnc2ccccc21>>C[C@H]1CCCN1C(=O)[C@H]1CCN(C(=O)OC(C)(C)C)C1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.Cc1c(C#N)ccc([N+](=O)[O-])c1N>>Cc1c(C#N)ccc(N)c1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.O=C(O)c1ccc(-c2ccccc2)cc1.O=S(Cl)Cl>>O=C(Cl)c1ccc(-c2ccccc2)cc1",
        "output": "3"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)CC(O)c1ccc(-c2ccc(N3C[C@H](Cn4ccnn4)OC3=O)cc2F)cn1.CCO.[BH4-].[Na+]>>CC(O)CC(O)c1ccc(-c2ccc(N3C[C@H](Cn4ccnn4)OC3=O)cc2F)cn1",
        "output": "91"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=C(Nc1cnc(OCC(F)(F)F)c(Br)c1)c1cccnc1.OB(O)c1ccc(Cl)c(F)c1>>O=C(Nc1cnc(OCC(F)(F)F)c(-c2ccc(Cl)c(F)c2)c1)c1cccnc1",
        "output": "833"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCN(CCCCN2CCNCC2)CC1.O=c1[nH]c(Cl)cc2c(Br)cccc12>>O=c1[nH]c(N2CCN(CCCCN3CCCCC3)CC2)cc2c(Br)cccc12",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.CN1CCN(Cc2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1.O.[Na]>>CN1CCN(Cc2ccc(N)cc2C(F)(F)F)CC1",
        "output": "507"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1ccc(O)cc1.CN(C)C=O.ClCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1ccc(OCc2ccccc2)cc1",
        "output": "49"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC1CNCCC1Nc1nc(Nc2cc(C)n(C)n2)ncc1Cl.CCN(CC)CC.CCO.N#Cc1ccc(Cl)nn1>>CCC1CN(c2ccc(C#N)nn2)CCC1Nc1nc(Nc2cc(C)n(C)n2)ncc1Cl",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(=O)O.CCN=C=NCCCN(C)C.Cl.N=C(NO)c1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1.On1nnc2ccccc21>>Cc1nc(-c2ccc3nc(N[C@@H]4CCc5ccccc54)ccc3c2)no1",
        "output": "895"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)S(=O)(=O)c1c(Cl)ccc(NC(=S)Nc2cccc(F)c2Cl)c1O.NC(=S)Nc1ccccc1.c1c[nH]cn1>>CN(C)S(=O)(=O)c1c(Cl)ccc(NC(=S)Nc2cccc(F)c2Cl)c1O[Si](C)(C)C(C)(C)C",
        "output": "746"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1cc(-c2nnnn2C)cc([N+](=O)[O-])c1.CCOC(C)=O.[Pd]>>CCOC(=O)c1cc(N)cc(-c2nnnn2C)c1",
        "output": "481"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cc1cc(Br)ccc1C(=O)O.Cl>>COC(=O)c1ccc(Br)cc1C",
        "output": "33"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc2c(Oc3ccc4cccnc4c3)ncnc2cc1OCc1ccccc1.O=C(O)C(F)(F)F>>COc1cc2c(Oc3ccc4cccnc4c3)ncnc2cc1O",
        "output": "23"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccccc1S(=O)(=O)Cl.Cn1cccc1CCN>>COc1ccccc1S(=O)(=O)NCCc1cccn1C",
        "output": "43"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=O.CCOC(C)=O.CO.COc1cc(SC)ccc1[N+](=O)[O-].O.O=S([O-])OO.[K+]>>COc1cc(S(C)(=O)=O)ccc1[N+](=O)[O-]",
        "output": "730"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCc1ccc(-c2ncc(C#N)c(O)n2)cc1.CCCCCc1ccc(C(=N)N)cc1.CCO.CCOC=C(C#N)C(=O)OCC.CC[O-].Cl.O=P(Cl)(Cl)Cl.[Na+].[Na+].[OH-]>>CCCCCc1ccc(-c2ncc(C#N)c(Cl)n2)cc1",
        "output": "25"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CCN(C(=O)c2ccc3c(c2)c2c(n3CC3CCOCC3)CCN(C(=O)OC(C)(C)C)C2)CC1.ClCCl.O=C(O)C(F)(F)F>>CC1CCN(C(=O)c2ccc3c(c2)c2c(n3CC3CCOCC3)CCNC2)CC1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCC2=NCCCN2CC1.CC#N.CCN=C=NCCCN(C)C.Cl.Cl.NCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C(O)Cc1ccc(Cl)cc1.On1nnc2ccccc21>>O=C(Cc1ccc(Cl)cc1)NCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O",
        "output": "599"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC(CC)Oc1ccc(I)nc1Cl.CCCCCC.CCOC(C)=O.CN>>CCC(CC)Oc1ccc(I)nc1NC",
        "output": "70"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CO.ClC(Cl)Cl.O.O=[N+]([O-])c1cnn(C2CCN(C3CC3)CC2)c1.[Cl-].[Fe].[NH4+]>>Nc1cnn(C2CCN(C3CC3)CC2)c1",
        "output": "628"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC(=O)c2ccccc2)CC1.CO.Cl.O.[BH4-].[Na+]>>CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC(O)c2ccccc2)CC1",
        "output": "24"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccccn1.Cl.Fc1ccc(-c2csc(CC3CNC3)n2)cc1.O=C(O)c1cccc(-c2noc(C(F)(F)F)n2)c1.On1nnc2ccccc21>>O=C(c1cccc(-c2noc(C(F)(F)F)n2)c1)N1CC(Cc2nc(-c3ccc(F)cc3)cs2)C1",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C(O)c1cnc2ccccc2c1O.O=S(Cl)Cl.c1ccccc1>>O=C(Cl)c1cnc2ccccc2c1O",
        "output": "188"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(O)CCO.CCOC(C)=O.ClCCl.O=C([O-])O.O=S(=O)(Cl)c1c(F)c(F)c(F)c(F)c1F.[Na+]>>CC(O)CCOS(=O)(=O)c1c(F)c(F)c(F)c(F)c1F",
        "output": "197"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COC(=O)C[C@@H](C)C(=O)O.F[P-](F)(F)(F)(F)F.c1ccc(C2NCCc3sccc32)cc1>>COC(=O)C[C@@H](C)C(=O)N1CCc2sccc2C1c1ccccc1",
        "output": "633"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C#N)c1ccc(Br)cc1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C>>CC(C)(C#N)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1",
        "output": "942"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CCc1oc(-c2ccccc2)nc1C(=O)Nc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2)cc1.Cl>>CCc1oc(-c2ccccc2)nc1C(=O)Nc1ccc(C2CCNCC2)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cc1c(C(=O)O)cc(O)c2cc(-c3ccc4c(c3)C(C)(C)CCC4(C)C)ccc12.O=S(=O)(O)O>>COC(=O)c1cc(O)c2cc(-c3ccc4c(c3)C(C)(C)CCC4(C)C)ccc2c1C",
        "output": "33"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)Cc1ccc(C(=O)NCCN(C)C(=O)OC(C)(C)C)cc1Oc1cccnc1.ClCCl.O=C(O)C(F)(F)F>>CNCCNC(=O)c1ccc(CN(C)C)c(Oc2cccnc2)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(CNc2nc(SC)nc(N3CCC(O)CC3)c2C(=O)OCCOCc2ccccc2)cc1Cl.ClCCl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.[Na+]>>COc1ccc(CNc2nc(S(C)=O)nc(N3CCC(O)CC3)c2C(=O)OCCOCc2ccccc2)cc1Cl",
        "output": "595"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCN.CCN(CC)CC.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ccc([N+](=O)[O-])s1>>CCCNC(=O)c1ccc([N+](=O)[O-])s1",
        "output": "736"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC[C@H](C)Nc1cc(C(=O)OC)cc(C(C)(F)F)n1.CO.Cl.[Li+].[OH-]>>CC[C@H](C)Nc1cc(C(=O)O)cc(C(C)(F)F)n1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.O=C(O)CCC(CNC(=O)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1)C(F)(F)F.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>O=C(NCC(CCCO)C(F)(F)F)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1",
        "output": "231"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)C(=O)c1ccc(C2(c3cccc(O)c3)CCCN(Cc3ccccc3)C2)cc1.ClCCl.O=C([O-])O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.[Na+].c1ccncc1>>CCN(CC)C(=O)c1ccc(C2(c3cccc(OS(=O)(=O)C(F)(F)F)c3)CCCN(Cc3ccccc3)C2)cc1",
        "output": "731"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.ClCCl.NCc1ccc(Cl)c(F)c1.O=C(Cl)C1CC1>>O=C(NCc1ccc(Cl)c(F)c1)C1CC1",
        "output": "206"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Clc1cc(Cl)ncn1.O=[N+]([O-])c1ccc(O)cc1F>>O=[N+]([O-])c1ccc(Oc2cc(Cl)ncn2)cc1F",
        "output": "668"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(N)C(=O)Nc1nc(-c2ccc(F)cc2)n(Cc2ccccc2)n1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCC[C@H]1C(=O)O.ClCCl.F[P-](F)(F)(F)(F)F.O>>CN1CCC[C@H]1C(=O)NC(C)(C)C(=O)Nc1nc(-c2ccc(F)cc2)n(Cc2ccccc2)n1",
        "output": "131"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CO.NCCCN>>CC(C)(C)OC(=O)NCCCN",
        "output": "631"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Nc1ncc(Cl)c(Cl)c1[N+](=O)[O-].[Ca+2].[Cl-].[Cl-].[Zn]>>Nc1ncc(Cl)c(Cl)c1N",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCCc1cc(C(=O)OCC)c2c(Cl)cccn12.CO.[Na+].[OH-]>>CCOCCc1cc(C(=O)O)c2c(Cl)cccn12",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)C=C(c2ccccc2N)CC1(C)C.Cl.ClCCNCCCl.Clc1ccccc1Cl>>CC1(C)C=C(c2ccccc2N2CCNCC2)CC1(C)C",
        "output": "640"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.Cl.O=C(O)CCc1ccc(Br)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCc1ccc(Br)cc1",
        "output": "231"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=C[C@H](OCc1ccccc1)C(C)(C)CO.CCOC(=O)OCCOC(=O)[C@H](OCc1ccccc1)C(C)(C)COS(=O)(=O)CCCCl.CS(C)=O.[N-]=[N+]=[N-].[Na+]>>CCOC(=O)OCCOC(=O)[C@H](OCc1ccccc1)C(C)(C)COS(=O)(=O)CCCN=[N+]=[N-]",
        "output": "243"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN1CCC(N)CC1.O=C(O)Cn1nc(-c2ccccc2)c2c(Cl)c(-c3ccccc3)nnc21>>CN1CCC(NC(=O)Cn2nc(-c3ccccc3)c3c(Cl)c(-c4ccccc4)nnc32)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCCc1cc(CCC=O)n(Cc2ccccc2)n1.Fc1ccccc1N1CCNCC1.[Na+]>>CCCCc1cc(CCCN2CCN(c3ccccc3F)CC2)n(Cc2ccccc2)n1",
        "output": "484"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CCN(C(C)C)C(C)C.CCOC(C)=O.Cc1ccnc2[nH]nc(C3CCNCC3)c12.Cl.N#C[C@@H]1C[C@@H]1COc1nc(Cl)nc(Cl)n1>>Cc1ccnc2[nH]nc(C3CCN(c4nc(Cl)nc(OC[C@H]5C[C@H]5C#N)n4)CC3)c12",
        "output": "214"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CSCc1cccc2c(C(CCOS(C)(=O)=O)c3ccc(F)cc3C)c[nH]c12.[C-]#N.[K+]>>CSCc1cccc2c(C(CCC#N)c3ccc(F)cc3C)c[nH]c12",
        "output": "705"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.O=C(O)CCC(=O)Nc1ccc([N+](=O)[O-])cc1.[Pd]>>Nc1ccc(NC(=O)CCC(=O)O)cc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)C(=O)c1cccc(CN(C)C(=O)OC(C)(C)C)c1CO.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CCN(CC)C(=O)c1cccc(CN(C)C(=O)OC(C)(C)C)c1COS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=C(Nc1ccccc1)[C@@H]1CCCN1C(=O)OCc1ccccc1.[C].[Pd]>>O=C(Nc1ccccc1)[C@@H]1CCCN1",
        "output": "568"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCc1nc2c(C)cc(-c3cn4ccccc4n3)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCCc1nc2c(C)cc(-c3cn4ccccc4n3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrC(Br)(Br)Br.COc1ccc(CC(=O)NCCc2ccc3[nH]cc(CCO)c3c2)cc1.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(CC(=O)NCCc2ccc3[nH]cc(CCBr)c3c2)cc1",
        "output": "378"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCNCC.COc1ccc(Cl)c2c1c1c(n2CCOCc2ccccc2)CCCC1C(=O)Cl.ClCCl>>CCN(CC)C(=O)C1CCCc2c1c1c(OC)ccc(Cl)c1n2CCOCc1ccccc1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)N=C=O.CCN(CC)CC.Cl.N#Cc1cccc(-c2nn(Cc3ccc(F)cc3F)c3c2CNCC3)c1>>CC(C)NC(=O)N1CCc2c(c(-c3cccc(C#N)c3)nn2Cc2ccc(F)cc2F)C1",
        "output": "437"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CNC(=O)c1ncccc1[N+](=O)[O-].CO.[H][H].[Pd]>>CNC(=O)c1ncccc1N",
        "output": "269"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1nc(C)n2c(=O)n(CC(=O)OCC)nc2c1Cc1ccc(NC(=O)c2ccccc2S(=O)(=O)O)cc1.Cl.O.[Na+].[OH-]>>CCCc1nc(C)n2c(=O)n(CC(=O)O)nc2c1Cc1ccc(NC(=O)c2ccccc2S(=O)(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.CC(C)OC(=O)c1cc(-n2c(Cl)nc(C(F)(F)F)c(F)c2=O)c(F)cc1Cl.[Na]>>CC(C)OC(=O)c1cc(-n2c(OC(C)C)nc(C(F)(F)F)c(F)c2=O)c(F)cc1Cl",
        "output": "37"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C(OCc1ccc([N+](=O)[O-])cc1)N1C[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1CO>>CS(=O)(=O)OC[C@@H]1C[C@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)CN1C(=O)OCc1ccc([N+](=O)[O-])cc1",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)NC(C)C.CCCCCC.Cc1ccc(F)nc1.II.O.O.O.O.O.O.O=S([O-])([O-])=S.[Li]CCCC.[Na+].[Na+]>>Cc1cnc(F)c(I)c1",
        "output": "850"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(F)ccc1Cl.O.[BH4-].[Na+]>>OCc1cc(F)ccc1Cl",
        "output": "444"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(c2cccc(N)c2)CC1.CC(C)C(=O)Cl.CCN(CC)CC>>CC(C)C(=O)Nc1cccc(C2CCN(C(=O)OC(C)(C)C)CC2)c1",
        "output": "9"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc2c(c1)CCNC2.C1CCOC1.CC(=O)Cl.CCN(CC)CC.Cl>>CC(=O)N1CCc2cc(Br)ccc2C1",
        "output": "240"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)CCO.CCOC(C)=O.Nc1cc2[nH]c(C(=O)O)cc2cc1OCc1ccccc1.O=C([O-])O.O=S(=O)(O)O.[Na+]>>CC(C)CCOC(=O)c1cc2cc(OCc3ccccc3)c(N)cc2[nH]1",
        "output": "331"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1cccnc1.CC(C)(C)[O-].Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Na+].[Pd].[Pd].c1ccc(CN2CCCC23CCNC3)cc1.c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>c1ccc(CN2CCCC23CCN(c2cccnc2)C3)cc1",
        "output": "597"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1ccc(-c2ncnc3c2ncn3-c2cc(C(=O)NC3CC3)ccc2C)cc1.NN.O>>Cc1ccc(C(=O)NC2CC2)cc1-n1cnc2c(-c3ccc(C(=O)NN)cc3)ncnc21",
        "output": "421"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CCc1ccc(Cl)cc1-c1[nH]ccc1C(=O)OC.CN(C)C=O.O.O=S(=O)(Cl)c1ccccc1>>CCc1ccc(Cl)cc1-c1c(C(=O)OC)ccn1S(=O)(=O)c1ccccc1",
        "output": "648"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)CC[C@@H](N)CSc1ccccc1.NS(=O)(=O)c1ccc(F)c(C(F)(F)F)c1>>CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(S(N)(=O)=O)cc1C(F)(F)F",
        "output": "572"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)c1ccc2c(Nc3cc(C(=O)O)ccc3Sc3ccc(NC(=O)OC(C)(C)C)cc3)ncnc2n1.CC(N)c1ccccc1F>>CC(C)c1ccc2c(Nc3cc(C(=O)NC(C)c4ccccc4F)ccc3Sc3ccc(NC(=O)OC(C)(C)C)cc3)ncnc2n1",
        "output": "753"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNC1.C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(OCC)c1cc2cncc(-c3cc(C=O)ccc3OC)c2o1.[Na+]>>CCOC(OCC)c1cc2cncc(-c3cc(CN4CCCC4)ccc3OC)c2o1",
        "output": "567"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)O.CCN(CC)CC.Cc1c(Cl)n(C)c(=O)n(C)c1=O.NCCO>>Cc1c(NCCO)n(C)c(=O)n(C)c1=O",
        "output": "166"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.O.O=[N+]([O-])c1cnn(C2CCOCC2)c1Cl.[Fe]>>Nc1cnn(C2CCOCC2)c1Cl",
        "output": "628"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Br.CC(=O)O.CCc1cnc(NC2CCN(C(=O)OC(C)(C)C)CC2)nc1.O>>CCc1cnc(NC2CCNCC2)nc1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.CCN(C(C)C)C(C)C.COc1ccnc2[nH]nc(C3CCNCC3)c12.N#C[C@@H]1C[C@@H]1COc1nc(Cl)nc(Cl)n1>>COc1ccnc2[nH]nc(C3CCN(c4nc(Cl)nc(OC[C@H]5C[C@H]5C#N)n4)CC3)c12",
        "output": "214"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)COc2c(F)c(F)c([N+](=O)[O-])c3c(=O)c(C(N)=O)cn1c23.CO.O.O=S([O-])S(=O)[O-].[Na+].[Na+]>>CC1(C)COc2c(F)c(F)c(N)c3c(=O)c(C(N)=O)cn1c23",
        "output": "202"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.Cl.Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NC1CCN(C(=O)OC(C)(C)C)C1>>Cn1ncc(NC(=O)c2nc(C3CC3)cnc2Nc2cncnc2)c1C(=O)NC1CCNC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CO.Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN)c1.ClC(Cl)Cl.O=CCc1cccnc1.O=S(=O)([O-])[O-].[BH3-]C#N.[Mg+2].[Na+]>>Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCNCCc2cccnc2)c1",
        "output": "426"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COc1cc2nccc(Oc3ccc([N+](=O)[O-])c(C(F)(F)F)c3)c2cc1C(N)=O.[C].[Pd]>>COc1cc2nccc(Oc3ccc(N)c(C(F)(F)F)c3)c2cc1C(N)=O",
        "output": "335"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1nc(C(C)(C)N)no1.O=C(O)c1ccc(C2CCCC2)c(-c2cccc(Cl)c2)n1>>Cc1nc(C(C)(C)NC(=O)c2ccc(C3CCCC3)c(-c3cccc(Cl)c3)n2)no1",
        "output": "137"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)N1CCC(Cc2ccc(S(=O)(=O)Cl)cc2)CC1.CCCN.CCN(CC)CC.Cl>>CCCNS(=O)(=O)c1ccc(CC2CCN(C(C)=O)CC2)cc1",
        "output": "43"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCCNCC1.CN1CCOCC1.CS(C)=O.Cl.O.O=C(O)Cn1cc(-c2cc3c(-c4cnc(C5(O)CCC5)s4)c(F)cnc3[nH]2)cn1.On1nnc2ccccc21>>CN1CCCN(C(=O)Cn2cc(-c3cc4c(-c5cnc(C6(O)CCC6)s5)c(F)cnc4[nH]3)cn2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N1CCc2cc(Br)ccc21.O=S(=O)(O)Cl>>CC(=O)N1CCc2cc(Br)c(S(=O)(=O)Cl)cc21",
        "output": "182"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCOC(=O)Cc1ccc(Oc2ccc(C(=O)NCCc3ccc(Cl)cc3)cc2)c(C)c1.CCOC(C)=O.Cl.O.[Na+].[OH-]>>Cc1cc(CC(=O)O)ccc1Oc1ccc(C(=O)NCCc2ccc(Cl)cc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(C)=O.COc1ccc([N+](=O)[O-])cc1Nc1ncnc2ccsc12.[Pd]>>COc1ccc(N)cc1Nc1ncnc2ccsc12",
        "output": "202"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCO.CN.Fc1ccc(-c2nc3nn(CCCCl)cc3c(-c3ccc(F)cc3)c2-c2ccncc2)cc1>>CNCCCn1cc2c(-c3ccc(F)cc3)c(-c3ccncc3)c(-c3ccc(F)cc3)nc2n1",
        "output": "279"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCC(C)C.CCOC(C)=O.CN(C)c1ccncc1.C[C@@](O)(C(=O)Nc1ccc(S(=O)(=O)Cl)cc1Cl)C(F)(F)F.ClCCl.Nc1ccccc1S(N)(=O)=O.c1ccncc1>>C[C@@](O)(C(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2S(N)(=O)=O)cc1Cl)C(F)(F)F",
        "output": "68"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Nc1cc(Br)ccn1.O.O=C(Cl)C1CC1>>O=C(Nc1cc(Br)ccn1)C1CC1",
        "output": "332"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.COC(=O)c1ccc(-c2nc3cc(-c4ccncc4F)c(-c4cccnc4)nc3[nH]2)cc1.Cl.[Na+].[OH-]>>O=C(O)c1ccc(-c2nc3cc(-c4ccncc4F)c(-c4cccnc4)nc3[nH]2)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(O)c1ccc(Br)cc1.CN(C)C=O.Cl.Clc1ccncn1.[H-].[Na+]>>CC(Oc1ccncn1)c1ccc(Br)cc1",
        "output": "653"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.O=C(Cl)OCCl.Oc1ccccc1.c1ccncc1>>O=C(OCCl)Oc1ccccc1",
        "output": "261"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.Nc1ccccc1S(N)(=O)=O>>CC(=O)Nc1ccccc1S(N)(=O)=O",
        "output": "9"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.COc1ccc(CO)cc1.O=Cc1ccc(O)c(C(=O)O)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(COC(=O)c2cc(C=O)ccc2O)cc1",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1.O=[N+]([O-])c1cc(C(O)(C(F)(F)F)C(F)(F)F)ccc1F>>C[C@H]1CN(c2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2[N+](=O)[O-])[C@H](C)CN1C(=O)OC(C)(C)C",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)C2CCC1(CS(=O)(=O)Cl)C(=O)C2.Cc1ccccc1N1CCNCC1.Cl.ClC(Cl)Cl>>Cc1ccccc1N1CCN(S(=O)(=O)CC23CCC(CC2=O)C3(C)C)CC1",
        "output": "584"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-c2ccc(NC(=O)c3oc(N4CCCC(C)C4)nc3C(F)(F)F)cc2)cc1.O.O.[Li+].[OH-]>>CC1CCCN(c2nc(C(F)(F)F)c(C(=O)Nc3ccc(-c4ccc(C(=O)O)cc4)cc3)o2)C1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)C[AlH]CC(C)C.CCCCCC.COC(=O)c1cc(F)c([N+](=O)[O-])c(F)c1.O=C([O-])C(O)C(O)C(=O)[O-].[K+].[K+]>>O=[N+]([O-])c1c(F)cc(CO)cc1F",
        "output": "444"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOc1ccccc1.CN(C)C=O.COc1cc(Br)cc(C(=O)O)c1Cl.ClCCl.O=C(Cl)C(=O)Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>CCOc1ccc(C(=O)c2cc(Br)cc(OC)c2Cl)cc1",
        "output": "275"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.O.[N-]=[N+]=NCCc1ccc2ccccc2c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NCCc1ccc2ccccc2c1",
        "output": "89"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.COCCOc1cc(OCC(=O)O)ccc1C(C)(C)C.CS(=O)(=O)Nc1ccc(CN)cc1F.Cl.O=C(n1ccnc1)n1ccnc1>>COCCOc1cc(OCC(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)ccc1C(C)(C)C",
        "output": "599"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Cl.CCN(C(C)C)C(C)C.ClCCl.OCc1nc(Cl)cc2c1c(OCc1ccccc1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1>>CC(=O)OCc1nc(Cl)cc2c1c(OCc1ccccc1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "126"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cn(C)c2c(c(Nc3ccc(I)cc3F)cc(=O)n2C)c1=O.[Li+].[OH-]>>Cn1cc(C(=O)O)c(=O)c2c(Nc3ccc(I)cc3F)cc(=O)n(C)c21",
        "output": "152"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC1CCc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2C1.Cl>>NC1CCc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2C1",
        "output": "538"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCc1nc(C)[nH]c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CI.CN(C)C=O.O.[H-].[Na+]>>CCCCc1nc(C)n(C)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "570"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C[Al+]CC(C)C.COC(=O)CCc1ccc(Cl)cc1C(F)(F)F.Cl.ClCCl.[H-]>>OCCCc1ccc(Cl)cc1C(F)(F)F",
        "output": "343"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.COC(=O)c1cccc(OCc2nc3ccc(Oc4ccccc4F)cc3n2C)c1.[Na+].[OH-]>>Cn1c(COc2cccc(C(=O)O)c2)nc2ccc(Oc3ccccc3F)cc21",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(C)(C)C.CCOC(C)=O.Cc1c(OC2CCN(C(=O)OC(C)(C)C)CC2F)ncnc1N1CCc2cc(C(=O)O)ccc21.O.O=C([O-])O.[NH4+].c1ccncc1>>Cc1c(OC2CCN(C(=O)OC(C)(C)C)CC2F)ncnc1N1CCc2cc(C(N)=O)ccc21",
        "output": "358"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1nc2nc(OCC)ccc2cc1NC(=O)OCc1ccccc1.O.O.[Li+].[OH-]>>CCOc1ccc2cc(NC(=O)OCc3ccccc3)c(C(=O)O)nc2n1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)N1CCC(=O)CC1.CO.Cl.NO>>CN(C)N1CCC(=NO)CC1",
        "output": "86"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(C(C)C)C(C)C.CCOC(=O)c1c(CN)nn(-c2cccc(OC(F)(F)F)c2)c1C1CC1.CCOC(C)=O>>CCOC(=O)c1c(CNC(C)=O)nn(-c2cccc(OC(F)(F)F)c2)c1C1CC1",
        "output": "45"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.CC(C)(C)c1cc(-c2ccc(N)cc2)cc(C(C)(C)C)c1O.O>>CC(=O)Nc1ccc(-c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(=O)Cl.CCCN(CCCc1ccc(F)cc1)C[C@@H]1C[C@H](N)CC[C@H]1NC(=O)OCc1ccccc1.CCN(CC)CC.ClCCl>>CCCN(CCCc1ccc(F)cc1)C[C@@H]1C[C@H](NC(=O)C(C)(C)C)CC[C@H]1NC(=O)OCc1ccccc1",
        "output": "45"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCl.O=S(Cl)Cl.OCc1cc(Cl)ccc1I.c1ccncc1>>ClCc1cc(Cl)ccc1I",
        "output": "81"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN(C)C1CCNCC1.CS(C)=O.O.O=c1cc(OCc2ccccc2)ccn1-c1ccc(Cl)nc1.[Cs+].[F-]>>CN(C)C1CCN(c2ccc(-n3ccc(OCc4ccccc4)cc3=O)cn2)CC1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=Cc1ccc2ccc3nc(N)[nH]c(=O)c3c2c1.CCO.[Pd]>>CCc1ccc2ccc3nc(N)[nH]c(=O)c3c2c1",
        "output": "555"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCBr.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].O=Cc1cc(O)ccc1OCc1ccccc1.[K+].[K+]>>C=CCOc1ccc(OCc2ccccc2)c(C=O)c1",
        "output": "77"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)O.COc1ccccc1OCCN.Cl.O.O=C([O-])[O-].[Ca+2].c1ccc2c(c1)[nH]c1cccc(OCC3CO3)c12>>COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12",
        "output": "16"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CC1(O)CCCC1.CO.O=C(OCc1ccccc1)N1CCC[C@@H]1Cc1c[nH]c2ccc(Br)cc12>>O=C(OCc1ccccc1)N1CCC[C@@H]1Cc1c[nH]c2ccc(C=CC3(O)CCCC3)cc12",
        "output": "539"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNCC1.CC(=O)O.CC(C)=O.CC(C)S(=O)(=O)Oc1ccc(CCOc2ccc(C=O)cc2)cc1.Cc1ccccc1.O.O=C1CSC(=O)N1>>CC(C)S(=O)(=O)Oc1ccc(CCOc2ccc(C=C3SC(=O)NC3=O)cc2)cc1",
        "output": "761"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(C2=C(C(=O)Nc3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cc3)CCCC2)cc1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(C2=C(C(=O)Nc3ccc(N4CCNCC4)cc3)CCCC2)cc1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1c2c(Cl)ccc([N+](=O)[O-])c2NS1(=O)=O.CCO.Cl[Sn]Cl.O=C([O-])O.[Na+]>>CC1c2c(Cl)ccc(N)c2NS1(=O)=O",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.OC1CN(C(c2ccccc2)c2ccccc2)C1>>CS(=O)(=O)OC1CN(C(c2ccccc2)c2ccccc2)C1",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Br.C1CCOC1.CO.N#Cc1ccnc(-c2csc(N=C(N)N)n2)c1.[Na+].[OH-]>>NC(=O)c1ccnc(-c2csc(N=C(N)N)n2)c1",
        "output": "419"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COCCOCC1(CNC(=O)[C@H]2C[C@@H](N)CN(C(=O)OCC3c4ccccc4-c4ccccc43)C2)c2ccccc2Oc2ccccc21.O=S(=O)(Cl)c1ccc(F)cc1>>COCCOCC1(CNC(=O)[C@H]2C[C@@H](NS(=O)(=O)c3ccc(F)cc3)CN(C(=O)OCC3c4ccccc4-c4ccccc43)C2)c2ccccc2Oc2ccccc21",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(=O)N1CCNCC1.CC(C)(C)[O-].Clc1cncc2ccc(Br)cc12.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(=O)N1CCN(c2ccc3cncc(Cl)c3c2)CC1",
        "output": "294"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNCc1ccc(C(=O)Nc2nc3c(OC)ccc(N4CCOCC4)c3s2)cc1.COCC(=O)Cl>>COCC(=O)N(C)Cc1ccc(C(=O)Nc2nc3c(OC)ccc(N4CCOCC4)c3s2)cc1",
        "output": "240"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.NC(=O)c1ccc(Cl)nc1OC1CCCC1.O=P(Cl)(Cl)Cl.c1ccncc1>>N#Cc1ccc(Cl)nc1OC1CCCC1",
        "output": "624"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(C)=O.ClCCCBr.O.O=C([O-])[O-].O=c1cc(-c2ccc(C(F)(F)F)cc2)ccn1-c1ccc2[nH]ncc2c1.[Cs+].[Cs+]>>O=c1cc(-c2ccc(C(F)(F)F)cc2)ccn1-c1ccc2c(cnn2CCCCl)c1",
        "output": "577"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)CC(F)(F)F.c1ccncc1>>CCOC(=O)CC(F)(F)F",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)c1ccc(C(F)(F)F)c(F)c1.Oc1ccc(OCCOC2CCOCC2)cc1>>CC(=O)c1ccc(C(F)(F)F)c(Oc2ccc(OCCOC3CCOCC3)cc2)c1",
        "output": "564"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1CC(Oc2cccc(NC(=O)c3ccc(F)cc3Cl)c2)CCN1C(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O>>CC1CC(Oc2cccc(NC(=O)c3ccc(F)cc3Cl)c2)CCN1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.O.OCCCCCBr.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCCCCBr",
        "output": "193"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(=O)OCC.COc1ccnc(C(C)=O)c1>>CCOC(=O)C(=O)CC(=O)c1cc(OC)ccn1",
        "output": "526"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCCCC1.CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O.CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O.CCCCCC.CN(C)C=O.CN1CCNCC1.Cc1ccccc1.NC(=O)CS(=O)(=O)c1ccccc1.O.O>>CC(C)(C)c1cc(C=C(C(N)=O)S(=O)(=O)c2ccccc2)cc(C(C)(C)C)c1O",
        "output": "314"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCN(CC)CCCl.CN(C)C=O.Cl.Cl.NCC1CNC(=O)CO1.O.O.O=C(O)c1cccnc1Oc1ccc(F)cc1.On1nnc2ccccc21>>O=C1COC(CNC(=O)c2cccnc2Oc2ccc(F)cc2)CN1",
        "output": "674"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.Cn1nc(Br)cc1C(C)(C)C(N)=O.O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C([O-])O.[Na+].c1ccncc1>>Cn1nc(Br)cc1C(C)(C)C#N",
        "output": "172"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Fc1ccccc1S(F)(F)(F)(F)F.O=S(=O)(O)O.O=[N+]([O-])O>>O=[N+]([O-])c1ccc(F)c(S(F)(F)(F)(F)F)c1",
        "output": "21"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CBr.CS(C)=O.C[O-].Oc1cccc2c1C[C@@H](NCc1ccccc1)[C@H](O)C2.[Na+]>>CCOC(=O)COc1cccc2c1C[C@@H](NCc1ccccc1)[C@H](O)C2",
        "output": "123"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CCN=C=NCCCN(C)C.CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)O)cc4)cc3)nc21.NCCO.On1nnc2ccccc21>>CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)NCCO)cc4)cc3)nc21",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)[O-].CC(=O)[O-].CCCCCC.CCOC(C)=O.CN(C)C=O.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.N#Cc1c(N)cc(N)nc1Br.O.O=C([O-])[O-].OB(O)c1ccccc1.[Na+].[Na+].[Pd+2]>>N#Cc1c(N)cc(N)nc1-c1ccccc1",
        "output": "869"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)[C@H](CNC(=O)c1cccs1)NC(=O)c1c(C)nc(NCC#Cc2ccc(O)cc2)nc1C.[Pd]>>COC(=O)[C@H](CNC(=O)c1cccs1)NC(=O)c1c(C)nc(NCCCc2ccc(O)cc2)nc1C",
        "output": "717"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)c1cc(-c2ccnn2C)co1.[Na+].[OH-]>>Cn1nccc1-c1coc(C(=O)O)c1",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C(=O)CCl.CN(C)C=O.O=C(Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1)NC1CCNCC1.O=C([O-])[O-].[Na+].[Na+]>>CN(C)C(=O)CN1CCC(NC(=O)Nc2ccc3nc(N[C@@H]4CCc5ccccc54)ccc3c2)CC1",
        "output": "340"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1CCNCC1.Cc1ccccc1.O=C([O-])[O-].O=[N+]([O-])c1ccc(Br)cc1F.[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])c(F)c2)CC1",
        "output": "294"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.O=C(O)/C=C/c1c[nH]c2ccccc12>>CC(C)(C)OC(=O)n1cc(/C=C/C(=O)O)c2ccccc21",
        "output": "748"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)CNc1nnc(-c2ccncc2Nc2ccc(I)cc2F)o1.O.[Li+].[OH-]>>O=C(O)CNc1nnc(-c2ccncc2Nc2ccc(I)cc2F)o1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.O.O=C(CCl)c1ccccc1.O=C([O-])[O-].[K+].[K+].c1ccc(N2CCNCC2)cc1>>O=C(CN1CCN(c2ccccc2)CC1)c1ccccc1",
        "output": "414"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C[C@H](NC(=O)c1ccc(-c2ccc(F)c(F)c2)cc1NC(=O)Nc1c(C)cc(C)cc1C)C(=O)OCc1ccccc1.CCOC(C)=O.CO.[H][H].[Pd]>>CCOC(=O)C[C@H](NC(=O)c1ccc(-c2ccc(F)c(F)c2)cc1NC(=O)Nc1c(C)cc(C)cc1C)C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(C(=O)O)cc(C)c1C(=O)c1cc(-n2ccnc2)ccc1Cl.O.[BH4-].[Na+].[Na+].[OH-]>>Cc1cc(C(=O)O)cc(C)c1C(O)c1cc(-n2ccnc2)ccc1Cl",
        "output": "157"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CN.CN(C)C=O.Cc1nc2c3c(c(C(=O)O)cc2n1C)CCC(c1ccccc1)N3.O>>CNC(=O)c1cc2c(nc(C)n2C)c2c1CCC(c1ccccc1)N2",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1nc(C(=O)O)c(-c2ccc(F)c(F)c2)s1.Cc1nc2sccn2c1C(=O)N[C@@H]1CCCNC1>>Cc1nc(C(=O)N2CCC[C@@H](NC(=O)c3c(C)nc4sccn34)C2)c(-c2ccc(F)c(F)c2)s1",
        "output": "747"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COc1ccc([N+](=O)[O-])c(CO)c1.O=[Pt].[H][H]>>COc1ccc(N)c(CO)c1",
        "output": "202"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC#N.COC(=O)c1ccc(-c2cc(-c3cnc(SC)nc3CN3C(=O)O[C@H](c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H]3C)c(OC)cc2F)c(C)c1.Cl.O.O.[Li+].[OH-]>>COc1cc(F)c(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(SC)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1nc(C#N)c2c(ccn2Cc2cccc(OC)c2)c1O.CO.C[O-].NCC(=O)O.[Na+]>>COc1cccc(Cn2ccc3c(O)c(C(=O)NCC(=O)O)nc(C#N)c32)c1",
        "output": "977"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1cccc(-c2ncc(C)cn2)c1.ClCCl.O.[BH4-].[Ca+2].[Cl-].[Cl-].[Na+].[Na+].[OH-]>>Cc1cnc(-c2cccc(CO)c2)nc1",
        "output": "444"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Clc1ncc(Cl)c(OC2CCOC2)n1.N>>Nc1ncc(Cl)c(OC2CCOC2)n1",
        "output": "312"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.CCO.CN(C)C(On1nnc2ccccc21)=[N+](C)C.C[C@@H](N)c1ccc2ccccc2c1.ClCCl.Cn1cc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1C(=O)O.F[B-](F)(F)F>>C[C@@H](NC(=O)c1cc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cn1C)c1ccc2ccccc2c1",
        "output": "905"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CCc1cc(-c2csc(-c3ccc(OCC)c(OCC)c3)n2)cc(C(=O)O)c1O.CO.[H][H].[Pd]>>CCCc1cc(-c2csc(-c3ccc(OCC)c(OCC)c3)n2)cc(C(=O)O)c1O",
        "output": "116"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1nc2ccccc2cc1N.ClCCl.O=C(Cl)Oc1ccccc1>>Cc1nc2ccccc2cc1NC(=O)Oc1ccccc1",
        "output": "763"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1c(CC(NC(=O)CCC#N)B2OC3CC4CC(C4(C)C)C3(C)O2)cccc1C(=O)OC(C)(C)C.Cl>>COc1c(CC(NC(=O)CCC#N)B2OC3CC4CC(C4(C)C)C3(C)O2)cccc1C(=O)O",
        "output": "752"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](O)C1.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CC[C@@H](OS(C)(=O)=O)C1",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C[C@@H]1CCCN1.NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1>>C[C@@H]1CCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1",
        "output": "214"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)CC(C)(C)n1cc(-c2ccnc3c2ccn3COCC[Si](C)(C)C)cn1.ClCCl.O.[H-]>>CC(C)(CCO)n1cc(-c2ccnc3c2ccn3COCC[Si](C)(C)C)cn1",
        "output": "225"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)c1ccncc1.CS(=O)(=O)Cl.NC(=O)Cc1cnc(Nc2ccc(N3CCC(CCO)CC3)cc2)cc1NCc1ccccc1.O=C([O-])O.[Na+]>>CS(=O)(=O)OCCC1CCN(c2ccc(Nc3cc(NCc4ccccc4)c(CC(N)=O)cn3)cc2)CC1",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCNc1ccc(CC)cc1.CN(C)c1ccncc1.ClCCCl.ClCCl.O=C(O)CBr>>CCc1ccc(N(CC)C(=O)CBr)cc1",
        "output": "315"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(CCC#N)(c1ccc(Cl)cc1)c1c[nH]c2c(CSC)cccc12.CO.ClCCl.O=C(OO)c1cccc(Cl)c1>>CCC(CCC#N)(c1ccc(Cl)cc1)c1c[nH]c2c(CS(C)=O)cccc12",
        "output": "13"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(OCCCBr)cc1.[K+].[K+].c1ccc2c(c1)CCNC2>>O=[N+]([O-])c1ccc(OCCCN2CCc3ccccc3C2)cc1",
        "output": "722"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=C(c1ccc(Nc2ncc([N+](=O)[O-])cn2)cn1)N1CCN(CCO)CC1>>Nc1cnc(Nc2ccc(C(=O)N3CCN(CCO)CC3)nc2)nc1",
        "output": "660"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(Br)cc(OCC)c2)c1CCC(=O)OCC.CS(=O)(=O)c1ccc(B(O)O)cc1.Cl[Pd]Cl.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(OCC)cc(-c3ccc(S(C)(=O)=O)cc3)c2)c1CCC(=O)OCC",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.COc1cc2c(cc1OC)C(C(O)c1ccc3c(c1)C=CC(C)(C)O3)CCO2.ClCCl.O=S([O-])([O-])=S.[Na+].[Na+]>>COc1cc2c(cc1OC)C(C(=O)c1ccc3c(c1)C=CC(C)(C)O3)CCO2",
        "output": "32"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)CCc1cccnc1>>O=C(Cl)CCc1cccnc1",
        "output": "56"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#Cc1ccc(C)cc1.CCNCC.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=C1Nc2ncccc2C12Cc1cc3ccc(Cl)nc3cc1C2>>Cc1ccc(C#Cc2ccc3cc4c(cc3n2)CC2(C4)C(=O)Nc3ncccc32)cc1",
        "output": "818"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COc1cc([N+](=O)[O-])ccc1Cl.[K+].[S-]c1ccncc1>>COc1cc([N+](=O)[O-])ccc1Sc1ccncc1",
        "output": "233"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCCNCC1.CCN(C(C)C)C(C)C.CCO.FC(F)(F)c1nnc2ccc(Cl)nn12>>CC(C)(C)OC(=O)N1CCCN(c2ccc3nnc(C(F)(F)F)n3n2)CC1",
        "output": "406"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COC(=O)c1ncoc1C1=Cc2cc(OC)ccc2-c2c(C3CCCCC3)c3ccc(C(=O)OC(C)(C)C)cc3n2C1.Cl.O=P([O-])(O)O.[Na+].[OH-]>>COc1ccc2c(c1)C=C(c1ocnc1C(=O)O)Cn1c-2c(C2CCCCC2)c2ccc(C(=O)OC(C)(C)C)cc21",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1nc(C#N)c2c(-c3ccc(OC)cc3)noc2c1O.C[O-].Cl.NCC(=O)O.O=C([O-])O.[Na+].[Na+]>>COc1ccc(-c2noc3c(O)c(C(=O)NCC(=O)O)nc(C#N)c23)cc1",
        "output": "977"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.COc1ccc(Br)cc1O.O=C(O)C(F)(F)F.O=C1CCC(=O)N1Cl>>COc1cc(Cl)c(Br)cc1O",
        "output": "121"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)CCc1ccc(Oc2ccc(C(N)=O)cn2)cc1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.ClCCCl.NCc1ccccc1.[Na+]>>CC(CCc1ccc(Oc2ccc(C(N)=O)cn2)cc1)NCc1ccccc1",
        "output": "589"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CCN(CC)CC.C[C@H]1COCCN1.O=Cc1cccc(Br)n1.[Na+]>>C[C@H]1COCCN1Cc1cccc(Br)n1",
        "output": "829"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1csc(Br)n1.CC#N.CCN(C(C)C)C(C)C.COC(=O)CC1CNC1.Cl>>COC(=O)CC1CN(c2nc(Br)cs2)C1",
        "output": "657"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)[O-].CC(C)[O-].CC(C)[O-].CCCCCCCCCC(=O)OCC.CCO[SiH](OCC)OCC.[Na+].[Nd+3].[OH-].[SiH4]>>CCCCCCCCCCO",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.Nc1ccc2c(c1)OCC2.O=C1CCC(=O)N1I>>Nc1cc2c(cc1I)CCO2",
        "output": "834"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCC(=O)OCCCCCCCCO.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CCCCCCCCCC(=O)OCCCCCCCCOS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)C(=O)Cl.CCN(C(C)C)C(C)C.CNC.ClCCl.O.O=C(O)c1cc(I)cc(F)c1F>>CN(C)C(=O)c1cc(I)cc(F)c1F",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1cnn(Cc2cc(-c3cccc(C(F)(F)F)c3)oc2C)c1.Cl.[Na+].[OH-]>>Cc1oc(-c2cccc(C(F)(F)F)c2)cc1Cn1cc(C(=O)O)cn1",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CN[C@H](CNC2CC2)C1.Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)O>>Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@H]1CNC1CC1",
        "output": "256"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.N#Cc1ccc2cc(C3CCN(C(=O)N4CCNCC4)CC3)ccc2c1.O=C(O)C1(O)CC1>>N#Cc1ccc2cc(C3CCN(C(=O)N4CCN(C(=O)C5(O)CC5)CC4)CC3)ccc2c1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.O=C(Cl)c1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1.c1ccc2c(c1)NCCO2>>O=C(c1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)N1CCOc2ccccc21",
        "output": "614"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1nc2ccc(N)nc2nc1C.O=C(O)C1CCN(c2cccc(C(F)(F)F)c2)CC1>>Cc1nc2ccc(NC(=O)C3CCN(c4cccc(C(F)(F)F)c4)CC3)nc2nc1C",
        "output": "368"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.O=P(Cl)(Cl)Cl.c1ccc(N2CCCC2)cc1>>O=Cc1ccc(N2CCCC2)cc1",
        "output": "239"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrP(Br)Br.CCN(CC)C(=O)C(CCOCCOCCOCCO)C(=O)N(CC)CC.ClCCl.O>>CCN(CC)C(=O)C(CCOCCOCCOCCBr)C(=O)N(CC)CC",
        "output": "301"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)CC1.CCOC(=O)N=NC(=O)OCC.COC(=O)Cc1cc(O)c2cc(F)ccc2c1.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)Cc1cc(OC2CCN(C(=O)OC(C)(C)C)CC2)c2cc(F)ccc2c1",
        "output": "846"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(OCC(C)(C)O)cc(C)c1-c1cccc(COc2ccc(CO)cc2)c1.ClC(Cl)Cl.[Mn+4].[O-2].[O-2]>>Cc1cc(OCC(C)(C)O)cc(C)c1-c1cccc(COc2ccc(C=O)cc2)c1",
        "output": "179"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CS(=O)(=O)Cc1cccc(Nc2ncnc(-c3ccc(F)cc3F)n2)c1.C[C@@H](O)c1ccc(F)cc1>>C[C@@H](Oc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=O)c2)n1)c1ccc(F)cc1",
        "output": "485"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)C1CC2CCC(C1)N2Cc1ccc2c(C#N)c(O[C@@H]3CC[C@H](C)CC3)ccc2c1.Cl.O.[Na+].[OH-]>>C[C@H]1CC[C@@H](Oc2ccc3cc(CN4C5CCC4CC(C(=O)O)C5)ccc3c2C#N)CC1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.CC(C)(C)[O-].CCOC(C)=O.CN1CCCC1CCCl.COc1cccc(CCCCc2ccccc2O)c1.Cl.O.[K+]>>COc1cccc(CCCCc2ccccc2OCCC2CCCN2C)c1",
        "output": "74"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)Nc1ccccc1N.CCN(C(C)C)C(C)C.CN(C)C=O.ClCCl.O=Cc1ccc(C(=O)Cl)cc1.O=Cc1ccc(C(=O)O)cc1.O=S(Cl)Cl>>CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(C=O)cc1",
        "output": "11"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COCCCn1c(C=O)cc2c3c(c(-c4ccccc4Cl)cc21)C(=O)NC3=O.CSC>>COCCCn1c(CO)cc2c3c(c(-c4ccccc4Cl)cc21)C(=O)NC3=O",
        "output": "745"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)C1(NC(=O)c2cccc3c2OCC3)Cc2ccccc2C1.O.[K+].[OH-]>>O=C(NC1(C(=O)O)Cc2ccccc2C1)c1cccc2c1OCC2",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.CCOC(C)=O.NC[C@H]1CN(c2ccc(N3CCOCC3)c(F)c2)C(=O)O1>>CC(=O)NC[C@H]1CN(c2ccc(N3CCOCC3)c(F)c2)C(=O)O1",
        "output": "339"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CO.COc1cc(Cl)cc(C(C)=O)c1OC.Cl.[BH3-]C#N.[NH4+].[Na+]>>COc1cc(Cl)cc(C(C)N)c1OC",
        "output": "552"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)CO.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)c1ccncc1.C[C@H](NC(=O)OC(C)(C)C)C(=O)O.ClCCl>>C[C@H](NC(=O)OC(C)(C)C)C(=O)OCC(C)(C)C",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCNCC1CO.O=c1[nH]c(Cl)cc2ccccc12>>CN1CCN(c2cc3ccccc3c(=O)[nH]2)CC1CO",
        "output": "220"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCc1c(C(=O)O)cccc1-c1ccccc1.ClCCl.O>>CCc1c(CO)cccc1-c1ccccc1",
        "output": "72"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)Cn1ccc2ccc(OCc3ccc(-c4cccc(C(F)(F)F)c4)nc3C)cc21.[Li+].[OH-]>>Cc1nc(-c2cccc(C(F)(F)F)c2)ccc1COc1ccc2ccn(CC(=O)O)c2c1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(CNC(=O)c2c(Oc3cccc(NC(=O)OC(C)(C)C)c3C)cc(=O)n(C)c2Nc2ccc(I)cc2F)cc1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(CNC(=O)c2c(Oc3cccc(N)c3C)cc(=O)n(C)c2Nc2ccc(I)cc2F)cc1",
        "output": "782"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc2c(c(Cl)c1Cl)C(=O)C(C)(c1cccs1)C2=O.Cl.c1ccncc1>>CC1(c2cccs2)C(=O)c2cc(O)c(Cl)c(Cl)c2C1=O",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "NC(=O)c1[nH]c2cnccc2c1-c1ccc(N)cc1.O=C=Nc1cccc(C(F)(F)F)c1F>>NC(=O)c1[nH]c2cnccc2c1-c1ccc(NC(=O)Nc2cccc(C(F)(F)F)c2F)cc1",
        "output": "473"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=c1[nH]c(=O)n(CCCCl)c2ccccc12.OC(c1ccccc1)(c1ccccc1)C1CCNCC1>>O=c1[nH]c(=O)n(CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)c2ccccc12",
        "output": "138"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)C(C)Oc1ccc(C=O)cc1.[BH4-].[Na+]>>COC(=O)C(C)Oc1ccc(CO)cc1",
        "output": "356"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=C(NCCCc1ccccc1)Nc1cccc(CCNC[C@H](O)c2ccc(OCc3ccccc3)c3[nH]c(=O)ccc23)c1.[Pd]>>O=C(NCCCc1ccccc1)Nc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)c1",
        "output": "264"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)C(NC(=O)CCc1ccc(O)cc1)C(C)C.Cl.[Li+].[OH-]>>CC(C)C(NC(=O)CCc1ccc(O)cc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOc1cc2ncc(C#N)c(Cl)c2cc1OC.Nc1cccc(Br)c1>>CCOc1cc2ncc(C#N)c(Nc3cccc(Br)c3)c2cc1OC",
        "output": "115"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O=C=Nc1ccccc1.O=c1ccn(C2CCNCC2)nc1-c1ccnn1-c1ccccc1>>O=C(Nc1ccccc1)N1CCC(n2ccc(=O)c(-c3ccnn3-c3ccccc3)n2)CC1",
        "output": "323"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](N)C1.CC(C)=O.CCO.[H][H].[Pd]>>CC(C)N[C@H]1CCN(C(=O)OC(C)(C)C)C1",
        "output": "236"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CNC=O.Cc1ncc(C(=O)O)c(O)c1Br.Cl.NCc1ccc(F)cc1.O.On1nnc2ccccc21>>Cc1ncc(C(=O)NCc2ccc(F)cc2)c(O)c1Br",
        "output": "790"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCI.CCOC(=O)c1ccc(-c2cc(C(F)(F)F)[nH]n2)s1.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1ccc(-c2cc(C(F)(F)F)n(CC)n2)s1",
        "output": "346"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.COc1cc2ncnc(Oc3ccc(N)c(C)c3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCCCOc1ccc(F)cc1>>COc1cc2ncnc(Oc3ccc(NC(=O)OCCCOc4ccc(F)cc4)c(C)c3C)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)NC(C)(C)c1ccc(C(F)(F)F)nc1.COC(C)(C)C.Cl.O.[Na+].[OH-]>>CC(C)(N)c1ccc(C(F)(F)F)nc1",
        "output": "412"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(C)=O.O.OCc1cccc2c1CCCN2CCOc1ccccc1>>O=Cc1cccc2c1CCCN2CCOc1ccccc1",
        "output": "179"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.CC(=O)O.N#Cc1cc(F)c(N)cc1F.O>>N#Cc1cc(F)c(N)c(Br)c1F",
        "output": "98"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCC1CCCCN1.COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1.NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1>>CC(C)(C)OC(=O)NCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1",
        "output": "214"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(C)=O.COCCOc1ccc2c(c1)[nH]c1c(C(=O)OC)nnc(-c3cccc(N)c3C)c12.ClCCl.O.O=Cc1ccc(Cl)cc1C(=O)O.[Na+]>>COCCOc1ccc2c(c1)[nH]c1c(C(=O)OC)nnc(-c3cccc(NCc4ccc(Cl)cc4C(=O)O)c3C)c12",
        "output": "359"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[C@@H]1C[C@H]1c1ccc(Cl)s1.CO.CON.Cl.c1ccncc1>>CON=C(C)[C@@H]1C[C@H]1c1ccc(Cl)s1",
        "output": "86"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1cn(C[C@H](C)O)c(C)n1.CO.Cl.[Na+].[OH-]>>Cc1nc(C(=O)O)cn1C[C@H](C)O",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN.CO.COC(=O)c1ccc(-c2nnc(Nc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc23)cc1>>CNC(=O)c1ccc(-c2nnc(Nc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc23)cc1",
        "output": "338"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "N#Cc1c([N+](=O)[O-])cccc1[N+](=O)[O-].OC1CCOC1>>N#Cc1c(OC2CCOC2)cccc1[N+](=O)[O-]",
        "output": "499"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCBr.O=C([O-])[O-].O=Cc1ccccc1O.[K+].[K+]>>C=CCOc1ccccc1C=O",
        "output": "77"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C2=NN(C3CCN(C(=O)CNC(=O)OC(C)(C)C)CC3)C(=O)C3(CCCC3)C2)cc1OC.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>COc1ccc(C2=NN(C3CCN(C(=O)CN)CC3)C(=O)C3(CCCC3)C2)cc1OC",
        "output": "431"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOCC.Cc1cc(Br)cc(C(=O)O)c1.O.O=S(=O)(O)O>>CCOC(=O)c1cc(C)cc(Br)c1",
        "output": "33"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)CCCCCBr.O=[N+]([O-])c1ccc(O)cc1Nc1ccccc1>>COC(=O)CCCCCOc1ccc([N+](=O)[O-])c(Nc2ccccc2)c1",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1c(N)ncnc1Nc1cc(C)c2n(c1=O)C1(CCNCC1)NC2=O.Cl.N#CCBr.[Cl-].[NH4+]>>COc1c(N)ncnc1Nc1cc(C)c2n(c1=O)C1(CCN(CC#N)CC1)NC2=O",
        "output": "880"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCC(C)(C)CC(O)CNC(=O)C(Cc1ccc(Br)cc1)NC(=O)OCc1ccccc1.ClCCl>>CCC(C)(C)CC(=O)CNC(=O)C(Cc1ccc(Br)cc1)NC(=O)OCc1ccccc1",
        "output": "87"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.C1CCOC1.CC(C)(C)[O-].N#Cc1c(Br)[nH]c(Br)c1Br.[K+]>>N#Cc1c(Br)c(Br)n(Cc2ccccc2)c1Br",
        "output": "528"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1CNCC(C)C1.CCC#CCOc1ncnc(Cl)c1F>>CCC#CCOc1ncnc(N2CC(C)CC(C)C2)c1F",
        "output": "296"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrC(Br)(Br)Br.CNC(=O)c1ccc(C=CC(=O)NCC(=O)N(C)c2ccc(Cl)c(CO)c2Cl)cc1.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CNC(=O)c1ccc(C=CC(=O)NCC(=O)N(C)c2ccc(Cl)c(CBr)c2Cl)cc1",
        "output": "750"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCN(c2cc(C(=O)O)cc(C(C)(C)C)c2)CC1.Cc1ccc(N)cc1-n1ccn2nc(-c3cccnc3)cc12.O=C(O)C(F)(F)F>>Cc1ccc(NC(=O)c2cc(N3CCN(C)CC3)cc(C(C)(C)C)c2)cc1-n1ccn2nc(-c3cccnc3)cc12",
        "output": "50"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C(O)c1ccnc(C(=O)O)c1.O=S(=O)(O)O>>COC(=O)c1cc(C(=O)O)ccn1",
        "output": "331"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)Nc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.CCN(CC)CC.CCOC(C)=O.CI.O>>CC(=O)N(C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1",
        "output": "237"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.CCCCCCC.CCOC(C)=O.Nc1cc(C(F)(F)F)c(Br)cn1>>CC(=O)Nc1cc(C(F)(F)F)c(Br)cn1",
        "output": "394"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.ClC(Cl)Cl.NCCN1CCCCC1.O.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2ncnc(Oc3ccc(NC(=O)NCCN4CCCCC4)cc3)c2cc1OC",
        "output": "913"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "N[C@@H](Cc1ccccc1)C(=O)N1CCSC1.O=C(O)c1cc2cc(F)cc(F)c2[nH]1>>O=C(N[C@@H](Cc1ccccc1)C(=O)N1CCSC1)c1cc2cc(F)cc(F)c2[nH]1",
        "output": "738"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "N#Cc1ccc(F)cc1Cl.OCCCS>>N#Cc1ccc(SCCCO)cc1Cl",
        "output": "503"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CN[C@@H](CN2CCCC2)C1.Nc1ncc(-c2ccc(C(=O)O)cc2)cc1OCc1c(Cl)cccc1Cl>>Nc1ncc(-c2ccc(C(=O)N3CCC[C@@H]3CN3CCCC3)cc2)cc1OCc1c(Cl)cccc1Cl",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCCCl.O=[N+]([O-])c1cccc(O)c1[N+](=O)[O-]>>CCOCCOc1cccc([N+](=O)[O-])c1[N+](=O)[O-]",
        "output": "74"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=C(Cl)OCc1ccccc1.OC1CCNC1.[K+].[OH-]>>O=C(OCc1ccccc1)N1CCC(O)C1",
        "output": "427"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1C(=O)n2c(nc3c(OCc4ccccc4)cccc32)C12CCN(c1ncnc3c1ncn3C(=O)OC(C)(C)C)CC2.CCO.CCOC(C)=O.CO.ClCCl.[Pd]>>CC(C)(C)OC(=O)N1C(=O)n2c(nc3c(O)cccc32)C12CCN(c1ncnc3c1ncn3C(=O)OC(C)(C)C)CC2",
        "output": "264"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCNCc1ccccc1.CN(C)c1ccncc1.COC(=O)c1ccccc1COc1ccc(CC(=O)O)cc1.Cl.ClCCCl.ClCCl.O>>CCCCCCN(Cc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2C(=O)OC)cc1",
        "output": "633"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(Cc2ccccc2)nc(Cl)n1.Cc1nccn1-c1ccc(N)cc1F>>Cc1cc(Cc2ccccc2)nc(Nc2ccc(-n3ccnc3C)c(F)c2)n1",
        "output": "808"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.ClCCCl.O=S(Cl)Cl.OCc1ccc(C2CCC2)c(C(F)(F)F)c1>>FC(F)(F)c1cc(CCl)ccc1C1CCC1",
        "output": "81"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Nc1ccc([N+](=O)[O-])c(N2CCCCCC2)c1.Cl>>Nc1ccc([N+](=O)[O-])c(N2CCCCCC2)c1",
        "output": "66"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCC.CN(C)C=O.C[S-].O=C(Cc1ccc(F)cc1F)c1ccc(Cl)nc1.[Na+]>>CSc1ccc(C(=O)Cc2ccc(F)cc2F)cn1",
        "output": "333"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(c1ccc(S(=O)(=O)N(CCCCCCCCCCCCCCC(=O)OC(C)(C)C)B(O)O)cc1)C(C)(C)C.O=C(O)C(F)(F)F>>CC(c1ccc(S(=O)(=O)N(CCCCCCCCCCCCCCC(=O)O)B(O)O)cc1)C(C)(C)C",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.COc1cccc2c1cnn2-c1ccc(F)cc1.ClCCl>>Oc1cccc2c1cnn2-c1ccc(F)cc1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCCCCCCCCCBr.CCCCCC.OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.[K+].[OH-]>>C=CCCCCCCCCCOCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F",
        "output": "95"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COc1cc(-c2cc3nccc(-c4cccc(OCc5ccccc5)c4)c3o2)cc(OC)c1OC.[Pd]>>COc1cc(-c2cc3nccc(-c4cccc(O)c4)c3o2)cc(OC)c1OC",
        "output": "23"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)C(OC(C)(C)C)c1c(C)cc2c(Br)cccc2c1-c1ccc(Cl)cc1.O.[Li+].[OH-]>>Cc1cc2c(Br)cccc2c(-c2ccc(Cl)cc2)c1C(OC(C)(C)C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC.ClCCl.Clc1cccc(Cl)c1CBr.Nc1ncccc1O.O.[Cl-].[Na+].[OH-]>>Nc1ncccc1OCc1c(Cl)cccc1Cl",
        "output": "623"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CCO.Cl.NO.O=C(O)Cc1ccc(CC2CCCCC2=O)cc1.[Na+]>>O=C(O)Cc1ccc(CC2CCCCC2=NO)cc1",
        "output": "86"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cl.O.O=C1CCc2cc(C(=O)CCCN(CCCl)CCCl)ccc2N1.[BH4-].[Na+].[Na+].[OH-]>>O=C1CCc2cc(C(O)CCCN(CCCl)CCCl)ccc2N1",
        "output": "24"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)c1ccc[nH]1.CO.COC(=O)c1cc(NC(=O)c2cc(NC(=O)OC(C)(C)C)cn2C)cn1C.[Na+].[OH-]>>Cn1cc(NC(=O)c2cc(NC(=O)OC(C)(C)C)cn2C)cc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)c1cc(CC(C)=O)on1.O.O=C([O-])[O-].[Cs+].[Cs+]>>CC(=O)Cc1cc(C(=O)O)no1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(CC(=O)O)cc1.Nc1ccc(Cl)c(Cl)c1>>COc1ccc(CC(=O)Nc2ccc(Cl)c(Cl)c2)cc1",
        "output": "365"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=C[C@]1(O)CCN[C@H]1C.N#Cc1ccc(F)cc1F.O=C([O-])[O-].[Li+].[Li+]>>C=C[C@]1(O)CCN(c2ccc(C#N)c(F)c2)[C@H]1C",
        "output": "26"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc(N)cc1Nc1ncncc1-c1cc(NCCN2CCOCC2)ncn1.Cn1nc(C(C)(C)C)cc1C(=O)O.F[P-](F)(F)(F)(F)F>>Cc1ccc(NC(=O)c2cc(C(C)(C)C)nn2C)cc1Nc1ncncc1-c1cc(NCCN2CCOCC2)ncn1",
        "output": "844"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)Cn1cc(C(N)=O)c2cc(Cl)ccc21.CO.ClCCl.O=C(O)C(F)(F)F>>NC(=O)c1cn(CC(=O)O)c2ccc(Cl)cc12",
        "output": "278"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OCC(=O)Nc1ccc(C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)cc1.CO.O.O=C([O-])[O-].[K+].[K+]>>NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(NC(=O)CO)cc1",
        "output": "687"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "NCCC(=O)O.O=C(O)c1ccc2c(c1)C(=O)OC2=O>>O=C(O)CCN1C(=O)c2ccc(C(=O)O)cc2C1=O",
        "output": "341"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(N)CC.ClCCl.O.O=S(=O)(Cl)c1ccc(F)cc1.c1ccncc1>>CCC(CC)NS(=O)(=O)c1ccc(F)cc1",
        "output": "43"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)=O.COC(=O)c1cc(OC)cc(OCc2ccccc2)c1.O.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[Li+].[Na+]>>COc1cc(CO)cc(OCc2ccccc2)c1",
        "output": "444"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1C2CCC1CN(C(=O)OCC1c3ccccc3-c3ccccc31)C2.ClCCl.O=C(O)C(F)(F)F>>O=C(OCC1c2ccccc2-c2ccccc21)N1CC2CCC(C1)N2",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.COC=CC(=O)Cl.COc1ccc(C(=O)N2CCN(c3ccc(N)cc3)CC2)cc1OC.c1ccccc1>>COC=CC(=O)Nc1ccc(N2CCN(C(=O)c3ccc(OC)c(OC)c3)CC2)cc1",
        "output": "10"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COB(OC)OC.Cc1ccc(Br)cc1.[Mg]>>Cc1ccc(B(O)O)cc1",
        "output": "789"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.Cl.O.O=C(O)Cc1ccc(O)c([N+](=O)[O-])c1.c1ccncc1>>CC(=O)Oc1ccc(CC(=O)O)cc1[N+](=O)[O-]",
        "output": "46"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCc1cnc(N2CCNCC2)c(C)c1.Cc1cc(C(=O)O)cnc1F>>CCc1cnc(N2CCN(C(=O)c3cnc(F)c(C)c3)CC2)c(C)c1",
        "output": "256"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@H]2C[C@@H](O)C2)c2ncnn12.CCOC(C)=O.CS(C)=O.Cc1cccc(C)n1.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n([C@H]2C[C@@H](O)C2)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1CCC(Oc2nccc(C(=O)O)c2Cl)CN1C(=O)c1ccccc1-n1nccn1.CO.C[Si](C)(C)C=[N+]=[N-].ClCCl>>COC(=O)c1ccnc(OC2CCC(C)N(C(=O)c3ccccc3-n3nccn3)C2)c1Cl",
        "output": "195"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)c1cnc(N)s1.CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl.On1nnc2ccccc21>>CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(C(C)=O)s1",
        "output": "681"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.C=CCCCCC(=O)O.CCCC[N+](CCCC)(CCCC)CCCC.CCN(CC)CC.CCOC(C)=O.[I-]>>C=CCCCCC(=O)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOCCn1c(CCl)nc2cncnc21.O=C([O-])O.[Na+].c1ccc(CN2CCNCC2)cc1>>CCOCCn1c(CN2CCN(Cc3ccccc3)CC2)nc2cncnc21",
        "output": "257"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.CN1CC(N)CN1C.COc1cc(N)c(Cl)cc1C(=O)O.ClCCl.O=C([O-])O.[Na+]>>COc1cc(N)c(Cl)cc1C(=O)NC1CN(C)N(C)C1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(C)NC(=O)C(Oc1ccc(C#N)c(C(F)(F)F)c1)C(C)(C)CO.CS(=O)(=O)Cl.c1ccncc1>>CCC(C)NC(=O)C(Oc1ccc(C#N)c(C(F)(F)F)c1)C(C)(C)COS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CCOC(=O)Cc1ccccc1OCCC(C)C.CC(C)CCn1c(=O)n(CCC(C)C)c2cc(C(=O)O)ccc21.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(C)CCOC(=O)Cc1cc(C(=O)c2ccc3c(c2)n(CCC(C)C)c(=O)n3CCC(C)C)ccc1OCCC(C)C",
        "output": "275"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCc1nc2cc3ccccc3cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCCc1nc2cc3ccccc3cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)[O-].C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.O=C1CCCCC1n1nc(-c2c(-c3ccccc3)nn3ccccc23)ccc1=O.[Br-].[K+]>>C=C1CCCCC1n1nc(-c2c(-c3ccccc3)nn3ccccc23)ccc1=O",
        "output": "601"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)c1ccc(COc2cccc(O)c2C=O)cc1.O.[Na+].[OH-]>>O=Cc1c(O)cccc1OCc1ccc(C(=O)O)cc1",
        "output": "5"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CO.N#C[C@@H]1C[C@@H]1COc1nc(Cl)nc(Cl)n1.NC(=O)c1nc(C2CCNCC2)ccc1N>>N#C[C@@H]1C[C@@H]1COc1nc(Cl)nc(N2CCC(c3ccc(N)c(C(N)=O)n3)CC2)n1",
        "output": "214"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.CO.COc1cc(C(=O)NC2CCN(C)CC2)ccc1N.Cc1ccc(S(=O)(=O)O)cc1.Cc1noc(C)c1CN1CCC(=O)N(C)c2cnc(Cl)nc21.O>>COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(Cc1c(C)noc1C)CCC(=O)N2C",
        "output": "941"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.Fc1ccc2c(N3CCNCC3)n[nH]c2c1.O.O=C([O-])[O-].O=C1c2ccccc2C(=O)N1CCBr.[K+].[K+]>>O=C1c2ccccc2C(=O)N1CCN1CCN(c2n[nH]c3cc(F)ccc23)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)CCCCn1c(=O)cc(Nc2ccc(C)c(CC)c2)[nH]c1=O.CO.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCc1cc(Nc2cc(=O)n(CCCCCO)c(=O)[nH]2)ccc1C",
        "output": "225"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C(=O)Nc1ccc(Cl)c(C#N)c1.O=[N+]([O-])O>>CCOC(=O)C(=O)Nc1cc(C#N)c(Cl)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)C(=O)Cl.COc1ccc(N2CCOCC2)c2sc(N)nc12>>COc1ccc(N2CCOCC2)c2sc(NC(=O)C(C)C)nc12",
        "output": "553"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cl[Pd]Cl.Fc1cc(Br)ccc1C(F)F.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc(C(F)F)c(F)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)N=C=O.CCN(C(C)C)C(C)C.CCOC(C)=O.ClCCl.O=C(OCc1ccccc1)N1CCNCC1>>CC(C)NC(=O)N1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "437"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.O=[N+]([O-])c1cc(C2CC2)c2[nH]ccc2c1.[Pd]>>Nc1cc(C2CC2)c2[nH]ccc2c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1c(Cl)ncc(C(=O)N2CCC(c3ccc(F)cc3)CC2)c1Cl.Cc1cccc(N)c1>>Cc1cccc(Nc2c(C(=O)N3CCC(c4ccc(F)cc4)CC3)cnc(Cl)c2C)c1",
        "output": "957"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)=O.CCOC(C)=O.COC(=O)Cc1nc(-c2ccc(Cl)cc2)sc1C(=O)Nc1ccc(OC2CN(C(=O)OC(C)(C)C)C2)c(OC)c1.O.[BH4-].[Li+]>>COc1cc(NC(=O)c2sc(-c3ccc(Cl)cc3)nc2CCO)ccc1OC1CN(C(=O)OC(C)(C)C)C1",
        "output": "343"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C[Si](C)(C)Cl.Cc1cc(F)ccc1[C@H]1C[C@@]2(CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC[C@@](C)(CO)N2.ClCCl.O>>Cc1cc(F)ccc1[C@H]1C[C@@]2(CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC[C@@](C)(CO[Si](C)(C)C)N2",
        "output": "193"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(CO)SC(F)(F)F.CCN(C(C)C)C(C)C.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(COS(=O)(=O)C(F)(F)F)SC(F)(F)F",
        "output": "582"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C2CCCC2)Cc2cc(OCCCC(=O)O)c(Cl)c(Cl)c2C1=O.CCO.O=S(=O)(O)O>>CCOC(=O)CCCOc1cc2c(c(Cl)c1Cl)C(=O)C(C)(C1CCCC1)C2",
        "output": "17"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CO.Cc1cccc(Cl)c1C=O.N#Cc1cc(-c2cccnc2)nn1-c1ccc(N)cc1.[BH3-]C#N.[Na+]>>Cc1cccc(Cl)c1CNc1ccc(-n2nc(-c3cccnc3)cc2C#N)cc1",
        "output": "359"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCS(=O)(=O)N[C@H]1CCNC[C@H]1COc1ccc(C(C)C)cc1.CI.Cl.O.O=C([O-])O.[Na+]>>CCS(=O)(=O)N[C@H]1CCN(C)C[C@H]1COc1ccc(C(C)C)cc1",
        "output": "483"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nn1nc(S(=O)(=O)c2ccccc2)c2ccccc2c1=O.O=C(O)Cc1ccc(Br)cc1>>O=C(Cc1ccc(Br)cc1)Nn1nc(S(=O)(=O)c2ccccc2)c2ccccc2c1=O",
        "output": "459"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C)(C)NN.CCCCOC(=O)CCC(C)=O>>CCCCOC(=O)CCC(C)=NNC(C)(C)CC",
        "output": "285"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.OCC[C@H]1CCc2sc3ncnc(Cl)c3c2C1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCC[C@H]1CCc2sc3ncnc(Cl)c3c2C1",
        "output": "193"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CCNCC2)nc1C(F)(F)F.Cc1ccccc1N=C=O>>CCOC(=O)c1cc(C#N)c(N2CCN(C(=O)Nc3ccccc3C)CC2)nc1C(F)(F)F",
        "output": "323"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(c2ccc(C(C)(C)C(F)(F)F)cc2)CC1C(=O)O.CCN(CC)CC.CCn1ccnc1C(=O)CN.CN(C)C=O.Cl.Cl.ClCCl.O=C(Cl)C(=O)Cl>>CCn1ccnc1C(=O)CNC(=O)C1CC1(C)c1ccc(C(C)(C)C(F)(F)F)cc1",
        "output": "645"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)[C@@H](N)Cc1ccccc1.CO[C@@H]([C@@H]1CCCN1C(=O)OC(C)(C)C)[C@@H](C)C(=O)O.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)[C@@H](OC)[C@@H]1CCCN1C(=O)OC(C)(C)C",
        "output": "129"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CCN1C(=O)C2CC(c3ccc([N+](=O)[O-])cc3)(C2)C1=O.Cl.O.[Sn]>>C=CCN1C(=O)C2CC(c3ccc(N)cc3)(C2)C1=O",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.C[Si](C)(C)Cl.O=C(O)c1cnc(NC2CCCCC2)c([N+](=O)[O-])c1>>COC(=O)c1cnc(NC2CCCCC2)c([N+](=O)[O-])c1",
        "output": "521"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC#Cc1ccc(C(=O)O)cc1.NCCc1ccc(CN2CCCC2)cc1>>CCCC#Cc1ccc(C(=O)NCCc2ccc(CN3CCCC3)cc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.COC(=O)c1cc2c([N+](=O)[O-])cccc2cn1.O.[Fe]>>COC(=O)c1cc2c(N)cccc2cn1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1c(C(=O)C(N)=O)c2c(OCC(=O)OC)nc(OC)nc2n1Cc1ccccc1.CO.Cl.O.[Na+].[OH-]>>CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)nc(OC)nc2n1Cc1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.CCCCOC(=O)N1CCN(C(=O)[C@H](CCCO)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NC3CCC3)n(-c3ccccc3)n2)CC1.CN(C)c1ccncc1.ClCCl.c1ccncc1>>CCCCOC(=O)N1CCN(C(=O)[C@H](CCCOC(C)=O)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NC3CCC3)n(-c3ccccc3)n2)CC1",
        "output": "254"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NCC1CCCO1.O=C(O)c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1>>O=C(NCC1CCCO1)c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CCCCCCCCCCCCCCCCCCCCCC(=O)O.CCOCC>>CCCCCCCCCCCCCCCCCCCCCCO",
        "output": "231"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCN(CC)CC.Cc1cc(Cl)nc(Cl)n1.Cc1ccc(N)cc1>>Cc1ccc(Nc2cc(C)nc(Cl)n2)cc1",
        "output": "161"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CNCc1ccc(S(=O)(=O)Nc2cc(F)c(C(=O)N[C@@H](Cc3ccc(-n4c(=O)ccn(C)c4=O)cc3)C(=O)O)c(F)c2)cc1.Cl.OCC1CCCCC1>>CNCc1ccc(S(=O)(=O)Nc2cc(F)c(C(=O)N[C@@H](Cc3ccc(-n4c(=O)ccn(C)c4=O)cc3)C(=O)OCC3CCCCC3)c(F)c2)cc1",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C(=O)Cl.Cl.Cl.Cl.ClCCl.N[C@@H]1CC[C@@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1>>CN(C)C(=O)N[C@@H]1CC[C@@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1",
        "output": "454"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CN(C)C=O.CN1C(=O)Cn2cc(C(=O)NCc3ccc(Cl)cc3)c(=O)c3cc(CCl)cc1c32.CNCC(O)c1ccc(O)c(OC)c1.Cl>>COc1cc(C(O)CN(C)Cc2cc3c4c(c2)c(=O)c(C(=O)NCc2ccc(Cl)cc2)cn4CC(=O)N3C)ccc1O",
        "output": "156"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](O)CC2)c2ccnn12.CCOC(C)=O.CN(C)C=O.O=C([O-])O.[Na+].c1c[nH]cn1>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](O[Si](C)(C)C(C)(C)C)CC2)c2ccnn12",
        "output": "193"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=[N+]([O-])c1ncccc1C1CC1.[Pd]>>Nc1ncccc1C1CC1",
        "output": "457"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN.CNC.O=C(O)Cc1ccccc1-c1ccc(C(=O)N2Cc3ccc(C(=O)NCc4cccnc4)n3Cc3ccccc32)cc1>>CNC(=O)Cc1ccccc1-c1ccc(C(=O)N2Cc3ccc(C(=O)NCc4cccnc4)n3Cc3ccccc32)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CC1(C)CCC(C)(C)c2cc(CCCO)c(Br)cc21.CCOCC.CN(C)C=O.c1c[nH]cn1>>CC1(C)CCC(C)(C)c2cc(CCCO[Si](C)(C)C(C)(C)C)c(Br)cc21",
        "output": "193"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCCC2(CCN(Cc3ccccc3)C2)C1CN.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>NCC1NCCCC12CCN(Cc1ccccc1)C2",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNCC1.CC(C)(C)[Si](C)(C)Oc1cccc(C2COc3cc(O[Si](C)(C)C(C)(C)C)ccc3N(C(=O)c3cccc(OCCCl)c3)C2)c1.CN(C)C=O.[I-].[K+]>>CC(C)(C)[Si](C)(C)Oc1cccc(C2COc3cc(O[Si](C)(C)C(C)(C)C)ccc3N(C(=O)c3cccc(OCCN4CCCCC4)c3)C2)c1",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)c1cccn(C(c2ccccc2)c2ccccc2)c1=O.[Na+].[OH-]>>CC(C)(C)OC(=O)NCCC[C@H](NC(=O)c1cccn(C(c2ccccc2)c2ccccc2)c1=O)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.ClCCl.N.O=C(O)c1cccc(N2CCOC2=O)c1.O=S(Cl)Cl>>NC(=O)c1cccc(N2CCOC2=O)c1",
        "output": "358"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.COc1ccc(CC2SC(=O)NC2=O)cc1C(=O)O.Cl.NCc1ccccn1.O>>COc1ccc(CC2SC(=O)NC2=O)cc1C(=O)NCc1ccccn1",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N(C)C.Cc1ccc(Oc2ccnc(Nc3ccc(S(=O)(=O)NCCCl)cc3)c2)c(C)n1.O=S1(=O)CCNCC1>>Cc1ccc(Oc2ccnc(Nc3ccc(S(=O)(=O)NCCN4CCS(=O)(=O)CC4)cc3)c2)c(C)n1",
        "output": "138"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCc1ccccc1B(O)O.O=C(Nc1cccc(Br)c1)OC1CN2CCC1CC2>>CCc1ccccc1-c1cccc(NC(=O)OC2CN3CCC2CC3)c1",
        "output": "837"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2ccc3c(c2)CN(C(=O)c2ccc(S(C)(=O)=O)c(F)c2C)CCO3)cc1.Cl.[Li+].[OH-]>>Cc1c(C(=O)N2CCOc3ccc(-c4ccc(C(=O)O)cc4)cc3C2)ccc(S(C)(=O)=O)c1F",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cl.ClCCl.O=C1CCN(Cc2ccccc2)CC1.OCCCNCCO.[Na+].[Na+].[OH-]>>OCCCN(CCO)C1CCN(Cc2ccccc2)CC1",
        "output": "187"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCNCC1.Cc1c(-c2cccc(CC(=O)O)c2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12>>Cc1c(-c2cccc(CC(=O)N3CCN(C)CC3)c2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)N(CC(=O)O)c2ccc3ncccc3c2)cc1.Cc1cccc(CNC2CC2)c1>>Cc1cccc(CN(C(=O)CN(c2ccc3ncccc3c2)S(=O)(=O)c2ccc(C(C)(C)C)cc2)C2CC2)c1",
        "output": "633"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1nc2c(-c3cccc(Cl)c3)cc(C=O)cc2s1.CO.Cl.ClCCl.O.[BH4-].[Na+]>>CC(C)(C)OC(=O)Nc1nc2c(-c3cccc(Cl)c3)cc(CO)cc2s1",
        "output": "356"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)CCN.CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O.O>>CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(O)Cc1ccc(N)cc1.Cc1cc(C)c([N+](=O)[O-])c(Cl)n1>>Cc1cc(C)c([N+](=O)[O-])c(Nc2ccc(CC(C)O)cc2)n1",
        "output": "434"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCOC(C)=O.Nc1ccccc1NC(=O)Nc1ccccc1.O=S(=O)(Cl)c1cccc2ccccc12>>O=C(Nc1ccccc1)Nc1ccccc1NS(=O)(=O)c1cccc2ccccc12",
        "output": "68"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrBr.COc1cc(C(C)=O)cc(OC)c1Br.ClCCl.O=C([O-])O.[Na+]>>COc1cc(C(=O)CBr)cc(OC)c1Br",
        "output": "173"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COC(C)(C)C.Nc1ccccc1C=O.O=C1CCC(=O)N1Br>>Nc1ccc(Br)cc1C=O",
        "output": "4"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cl.ClCCl.Nc1ccccc1F.O=S(=O)(Cl)CCc1ccccc1Br.c1ccncc1>>O=S(=O)(CCc1ccccc1Br)Nc1ccccc1F",
        "output": "194"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.Cl.N#Cc1ccc(Br)cc1.[Cl-].[Li]CCCC.[Na+]>>N#Cc1ccc(B(O)O)cc1",
        "output": "832"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.COc1cc2c(Cl)ncnc2cc1OCCCN1CCN(C)CC1.O=C([O-])[O-].Oc1ccc2[nH]ccc2c1F.[K+].[K+]>>COc1cc2c(Oc3ccc4[nH]ccc4c3F)ncnc2cc1OCCCN1CCN(C)CC1",
        "output": "668"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NC1CCNCC1.CCN(C(C)C)C(C)C.ClCCl.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>CC(C)(C)OC(=O)NC1CCN(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)CC1",
        "output": "99"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCCN(CCC)CC1CCCCN1CCN.O=C1Nc2cccnc2N(C(=O)Cl)c2ccccc21>>CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2C(=O)Nc2cccnc21",
        "output": "454"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.OCc1cc2ccoc2cn1>>O=Cc1cc2ccoc2cn1",
        "output": "263"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCC(=O)Nc1nn(COCC[Si](C)(C)C)c2cc(-c3cccc(OCc4ccccc4)c3)ccc12.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.[F-]>>CCCC(=O)Nc1n[nH]c2cc(-c3cccc(OCc4ccccc4)c3)ccc12",
        "output": "813"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1ccc(NC2CCN(Cc3ccccc3)CC2)nc1.[OH-].[OH-].[Pd+2]>>Cc1ccc(NC2CCNCC2)nc1",
        "output": "84"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN1C(=O)Cc2cc(Br)ccc21.CS(C)=O.Cl[Pd]Cl.O.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CN1C(=O)Cc2cc(B3OC(C)(C)C(C)(C)O3)ccc21",
        "output": "942"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClC(Cl)Cl.N#Cc1ccccc1-c1ccccc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=[N+]([O-])[O-].[NH4+]>>N#Cc1cc([N+](=O)[O-])ccc1-c1ccccc1",
        "output": "103"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CO.O=[N+]([O-])c1ccc(NCCCCN2CCOCC2)c(F)c1.[Pd]>>Nc1ccc(NCCCCN2CCOCC2)c(F)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(CCO)c1ccc(-c2nc3ccccc3s2)cc1.Clc1nc(Cl)nc(Cl)n1>>CN(CCOc1nc(Cl)nc(Cl)n1)c1ccc(-c2nc3ccccc3s2)cc1",
        "output": "213"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1ccc(CCC(=O)OC(C)(C)C)[nH]1.Cl>>COC(=O)c1ccc(CCC(=O)O)[nH]1",
        "output": "278"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)N(C)C.CO.COC(=O)[C@H](Cc1ccc(C(=O)NCc2cnc3c(c2)CCCN3)cc1)NC(=O)c1c(Cl)cccc1Cl.O.[Li+].[OH-]>>O=C(NCc1cnc2c(c1)CCCN2)c1ccc(C[C@H](NC(=O)c2c(Cl)cccc2Cl)C(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=C1c2ccc(OC)cc2CC(=O)c2ccccc21.CC(=O)[O-].CO.Cl.NO.[Na+]>>C=C1c2ccc(OC)cc2CC(=NO)c2ccccc21",
        "output": "212"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "N#Cc1cccc(S(=O)(=O)Cl)c1.Nc1ccc(Cl)cc1C(=O)c1ccccc1>>N#Cc1cccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccccc2)c1",
        "output": "68"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)CC1.CCOC(=O)/N=N/C(=O)OCC.O.Oc1ccc(F)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(F)cc2)CC1",
        "output": "846"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)CCc1cc(-c2ccc(OC(F)(F)F)cc2)nn1C.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cn1nc(-c2ccc(OC(F)(F)F)cc2)cc1CCCO",
        "output": "225"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(=O)CCC3(C)C)nc1.CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(C)(C)CCC3O)cc1>>CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(O)CCC3(C)C)nc1",
        "output": "24"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC1(C)OB(c2ccc3[nH]ccc3c2)OC1(C)C.ClCCl.Cl[Pd]Cl.Cn1ncc2c(=O)n(C[C@@H]3CCN(C(=O)C4CC4)C3)c(-c3ccc(Br)cc3)nc21.O.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cn1ncc2c(=O)n(C[C@@H]3CCN(C(=O)C4CC4)C3)c(-c3ccc(-c4ccc5[nH]ccc5c4)cc3)nc21",
        "output": "933"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCOC(=O)C1=C(COCCNC)NC(C)=C(C(=O)OC)C1c1ccccc1Cl.CS(=O)(=O)Cl.ClCCl>>CCOC(=O)C1=C(COCCN(C)S(C)(=O)=O)NC(C)=C(C(=O)OC)C1c1ccccc1Cl",
        "output": "584"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC1(C)OB(c2cnc3c(c2)CCCN3C(N)=O)OC1(C)C.CCOC(C)=O.CS(=O)(=O)CCCOCc1cncc(Br)c1.O.O=C([O-])[O-].[Na+].[Na+]>>CS(=O)(=O)CCCOCc1cncc(-c2cnc3c(c2)CCCN3C(N)=O)c1",
        "output": "967"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1ccc(-n2cc(C#N)c(-c3ccccc3)c2)cc1[N+](=O)[O-].CCOC(C)=O.CO.[C].[Pd]>>CCOC(=O)c1ccc(-n2cc(C#N)c(-c3ccccc3)c2)cc1N",
        "output": "268"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N[C@@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)O.CC(=O)SCCN.CCOCC.Cl.Cl.ClCCl.NCCSC(=O)c1ccccc1>>CC(=O)N[C@@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)NCCSC(=O)c1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1ccc(-n2cnc3c(NC4CC4)nc(C(F)(F)F)nc32)cc1.O=C(O)C(F)(F)F.[K+].[OH-]>>O=C(O)c1ccc(-n2cnc3c(NC4CC4)nc(C(F)(F)F)nc32)cc1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCOC(C)=O.Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc(N)c(C(=O)c2cccc(Cl)c2)c1.O=C(Br)CBr.[Na+].[OH-]>>Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc(NC(=O)CBr)c(C(=O)c2cccc(Cl)c2)c1",
        "output": "442"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrP(Br)Br.COc1ccc2c(c1)CC(CCO)CC2.Cc1ccccc1.O.c1ccncc1>>COc1ccc2c(c1)CC(CCBr)CC2",
        "output": "301"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)Cc1c2c(nn1-c1ccccc1)c(=O)[nH]c1ccccc12.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>O=c1[nH]c2ccccc2c2c(CCO)n(-c3ccccc3)nc12",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(N)cc4)nc32)CC1.CN(C)C=O.CNS(=O)(=O)Cl.c1ccncc1>>CNS(=O)(=O)Nc1ccc(-c2nc(N3CCOCC3)c3cnn(C4CCN(C(=O)OC(C)(C)C)CC4)c3n2)cc1",
        "output": "395"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.NN.O.O=C1c2ccccc2C(=O)N1Cc1cnc(Nc2cccc(Cl)c2)nc1C(F)(F)F>>NCc1cnc(Nc2cccc(Cl)c2)nc1C(F)(F)F",
        "output": "242"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)C(=O)Cl.COCCCN1CCOc2ccc(COC3CN(C(=O)OCc4ccccc4)CC(O)C3c3ccc(OC)cc3)cc21.c1ccncc1>>COCCCN1CCOc2ccc(COC3CN(C(=O)OCc4ccccc4)CC(OC(=O)C(C)(C)C)C3c3ccc(OC)cc3)cc21",
        "output": "126"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)Cl.CC1(C)OB(c2ccc(N3CCNCC3)cc2)OC1(C)C.Cl.O=C([O-])[O-].[Cs+].[Cs+]>>CC(=O)N1CCN(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COC(=O)c1cnc2c(c1)NC(=O)C1CN(C(=O)OC(C)(C)C)CCN21.O.[Al+3].[H-].[H-].[H-].[H-].[H-].[Li+].[Na+]>>CC(C)(C)OC(=O)N1CCN2c3ncc(CO)cc3NC(=O)C2C1",
        "output": "522"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)CNC(=O)CCCCCN.COc1ccc(C(=O)O)cc1>>CCOC(=O)CNC(=O)CCCCCNC(=O)c1ccc(OC)cc1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc(CC(=O)O)cc(OC)c1.Nc1nn2cccnc2c1-c1cccc(F)c1>>COc1cc(CC(=O)Nc2nn3cccnc3c2-c2cccc(F)c2)cc(OC)c1",
        "output": "795"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1cc2c(=O)n(CC(=O)c3ccc(OC)c(OC)c3)c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3)c2s1.CS(C)=O.ClC(Cl)Cl.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCc1cc2c(=O)n(CC(=O)c3ccc(OC)c(OC)c3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c2s1",
        "output": "979"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CC(O)c1ccc(-c2ccc(O)cc2)cc1.O=S(=O)(O)O>>CC(=O)Oc1ccc(-c2ccc(C(C)O)cc2)cc1",
        "output": "46"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CCO.NC(N)=S.O=C(CBr)c1cccc([N+](=O)[O-])c1.[Na+]>>Nc1nc(-c2cccc([N+](=O)[O-])c2)cs1",
        "output": "716"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrP(Br)Br.CN(C)C(=O)C(CCOCCOCCOCCO)C(=O)N(C)C.ClCCl.O>>CN(C)C(=O)C(CCOCCOCCOCCBr)C(=O)N(C)C",
        "output": "301"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCCCC1.CCOC(=O)CC1(C)NCCc2c1[nH]c1ccccc21.CN=C=O>>CCOC(=O)CC1(C)c2[nH]c3ccccc3c2CCN1C(=O)NC",
        "output": "437"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCO.COC(=O)c1ccc(-c2ccc3cc(C(=O)O)ccc3c2)cc1C12CC3CC(CC(C3)C1)C2.[K+].[OH-]>>O=C(O)c1ccc2cc(-c3ccc(C(=O)O)c(C45CC6CC(CC(C6)C4)C5)c3)ccc2c1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)C1CCC(C)=CC1NC(=O)OC(C)(C)C.[Na+].[OH-]>>CC1=CC(NC(=O)OC(C)(C)C)C(C(=O)O)CC1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)C(CCn1nnc2ccc(C)cc2c1=O)Sc1ccc(NC(=O)c2ccc(C)cc2)cc1.O.O=S([O-])O.[Li+].[Na+].[OH-]>>Cc1ccc(C(=O)Nc2ccc(SC(CCn3nnc4ccc(C)cc4c3=O)C(=O)O)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(N)CO.COc1ccc(F)cc1C(=O)c1cnc(NC2CCN(S(=O)(=O)CCCCl)CC2)nc1N>>COc1ccc(F)cc1C(=O)c1cnc(NC2CCN(S(=O)(=O)CCCNC(C)(C)CO)CC2)nc1N",
        "output": "279"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOc1ncc(Br)cc1N1CCOCC1.Cc1ccc(N)cc1B(O)O>>CCOc1ncc(-c2cc(N)ccc2C)cc1N1CCOCC1",
        "output": "833"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(C(=O)CCCCl)cc1C.O=C(Nc1cccc(C2CCNCC2)c1)C1CC1>>Cc1ccc(C(=O)CCCN2CCC(c3cccc(NC(=O)C4CC4)c3)CC2)cc1C",
        "output": "138"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br.CC(=O)O.CCCCn1c(=O)cnn(-c2ccc(N3CCN(c4ccc(OC)cc4)CC3)cc2)c1=O.O.O=S([O-])O.[Na+]>>CCCCn1c(=O)cnn(-c2ccc(N3CCN(c4ccc(O)cc4)CC3)cc2)c1=O",
        "output": "402"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CO.O=[N+]([O-])c1ccccc1Nc1ccc(F)c(F)c1.[Pd]>>Nc1ccccc1Nc1ccc(F)c(F)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCO.CCOC(=O)CC(=O)c1ccc(Cl)c(OC)c1.CCn1nccc1-c1cn[nH]c1N.Cc1ccc(S(=O)(=O)O)cc1>>CCn1nccc1-c1cnn2c(=O)cc(-c3ccc(Cl)c(OC)c3)[nH]c12",
        "output": "513"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Nc1ccc(NC(=O)OCC(Cl)(Cl)Cl)cn1.CCN(C(C)C)C(C)C.CS(C)=O.O.c1ccc(-c2cccc(N3CCNCC3)c2)cc1>>CC(=O)Nc1ccc(NC(=O)N2CCN(c3cccc(-c4ccccc4)c3)CC2)cn1",
        "output": "980"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cnc(Oc2ccccc2)nc1.CO.O.O.[Li+].[OH-]>>O=C(O)c1cnc(Oc2ccccc2)nc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCI.CS(=O)(=O)c1cc(N2CCNCC2)ccc1Cl>>CCCN1CCN(c2ccc(Cl)c(S(C)(=O)=O)c2)CC1",
        "output": "184"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN.CCOC(C)=O.ClCCCl.O=Cc1c(F)cccc1Cl.[Na+].[Na+].[OH-]>>CCNCc1c(F)cccc1Cl",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCCc1nnc(OC2CCNCC2CO)cc1-c1ccc(OC2CCCCC2)cc1.Cl.Cl.ClCCl.[Na+]>>CCCCc1nnc(OC2CCN(C)CC2CO)cc1-c1ccc(OC2CCCCC2)cc1",
        "output": "217"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1ccc(-n2cc(-c3ccc(Cl)cc3Cl)nc2Cc2ccc(Br)cc2)cc1.OB(O)c1ccc(O)cc1>>CCOC(=O)c1ccc(-n2cc(-c3ccc(Cl)cc3Cl)nc2Cc2ccc(-c3ccc(O)cc3)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Oc1ccc(NC(=O)c2ccc(Cl)cc2)c(NC(=O)OC(c2ccncc2)C2CCNCC2)c1.Cl>>O=C(Nc1cc(O)ccc1NC(=O)c1ccc(Cl)cc1)OC(c1ccncc1)C1CCNCC1",
        "output": "754"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)C(=O)Cl.CCN(CC)CC.COC(=O)CC1CCC(c2ccc(-c3ccc(N)cn3)cc2)CC1.ClCCl>>COC(=O)CC1CCC(c2ccc(-c3ccc(NC(=O)C(C)(C)C)cn3)cc2)CC1",
        "output": "422"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.O.O=C(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(F)c(Br)c1.[C-]#N.[C-]#N.[Zn+2]>>N#Cc1cc(C(=O)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F",
        "output": "65"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1cc(C)n(-c2cccc(Br)c2)c1-c1ccccc1.[Li+].[OH-]>>Cc1cc(C(=O)O)c(-c2ccccc2)n1-c1cccc(Br)c1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.Cl.O=S(=O)(c1ccc(Br)cc1Cl)C1CC1.[Li]CCCC>>O=S(=O)(c1ccc(B(O)O)cc1Cl)C1CC1",
        "output": "832"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCNCC1.COc1cc(Br)ccc1C=O.ClCCl.O.[Na+]>>COc1cc(Br)ccc1CN1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN1CCc2nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)cc2C1.NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)C(=O)CCC4)cc2)CCC1>>CCN1CCc2nc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)cc2C1",
        "output": "793"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.COCOc1ccc(C2COc3cc(OCOC)ccc3C2(O)c2cccc(O)c2)cc1.ClCCCCCBr.O.[Na+].[OH-]>>COCOc1ccc(C2COc3cc(OCOC)ccc3C2(O)c2cccc(OCCCCCCl)c2)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.Cc1cc(F)ccc1CCl.ClCCl.O.O=S(=O)([O-])O.[C-]#N.[K+].[Na+].[OH-]>>Cc1cc(F)ccc1CC#N",
        "output": "38"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1nc(O)cc(-c2ccco2)n1.O=P(Cl)(Cl)Cl>>Nc1nc(Cl)cc(-c2ccco2)n1",
        "output": "168"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)C[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1.CO.[C].[H][H].[Pd]>>CC(C)C[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.C[C@@H]1CN(c2ccc3c(F)cccc3c2)CCN1C(=O)C(F)(F)F.[BH4-].[Na+]>>C[C@@H]1CN(c2ccc3c(F)cccc3c2)CCN1",
        "output": "703"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)c1ccc(-c2cnc(OC)c(-c3cnc(N4CCOCC4)nc3CN3C(=O)O[C@H](c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H]3C)c2)c(C)c1.NN>>COc1ncc(-c2ccc(C(=O)NN)cc2C)cc1-c1cnc(N2CCOCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C",
        "output": "421"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.CO.ClC(Cl)Cl.N#Cc1ccc(N2CCNCC2)cc1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)c1nc(N2CCN(CCCCNC(=O)N3CCN(c4ccc(C#N)cc4)CC3)CC2)cc(C(F)(F)F)n1",
        "output": "734"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc(-c2cncc3ccc(C(=O)O)nc23)cc1.F[P-](F)(F)(F)(F)F.NCCC(F)(F)F>>COc1ccc(-c2cncc3ccc(C(=O)NCCC(F)(F)F)nc23)cc1",
        "output": "137"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)[O-].CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O.O=C1CSC(=O)N1.[Na+]>>CC(C)(C)c1cc(C=C2SC(=O)NC2=O)cc(C(C)(C)C)c1O",
        "output": "761"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCOC(C)=O.CN(C)C=O.C[C@H](CCO)[C@@H](c1ccco1)N(C)C(=O)OC(C)(C)C.c1c[nH]cn1>>C[C@H](CCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)[C@@H](c1ccco1)N(C)C(=O)OC(C)(C)C",
        "output": "602"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccccc1CN.O=[N+]([O-])c1cccc2nc(Cl)ccc12>>COc1ccccc1CNc1ccc2c([N+](=O)[O-])cccc2n1",
        "output": "612"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(C)=O.Cl.ClCCN1CCCC1.Ic1ccc2[nH]ncc2c1.O.O=C([O-])[O-].[Cs+].[Cs+]>>Ic1ccc2c(cnn2CCN2CCCC2)c1",
        "output": "604"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cc(C(C)(C)C)c(O)c(S(=O)(=O)Cl)c1.Nc1ccc(I)cc1>>Cc1cc(C(C)(C)C)c(O)c(S(=O)(=O)Nc2ccc(I)cc2)c1",
        "output": "68"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCCCCCCCCCOCC(CI)(COCCCCCCCCCCCCCCCCCC)COCCCCCCCCCCCCCCCCCC.CN(C)C=O.Cl.O=C([O-])[O-].O=C1c2ccccc2-c2ccc(O)cc21.[K+].[K+]>>CCCCCCCCCCCCCCCCCCOCC(COCCCCCCCCCCCCCCCCCC)(COCCCCCCCCCCCCCCCCCC)COc1ccc2c(c1)C(=O)c1ccccc1-2",
        "output": "198"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=C(Cl)N(C)C.CC(C)N.CCN(C(C)C)C(C)C.Cc1ccccc1COc1cc(-n2cnc3ccccc32)sc1C(=O)O.ClCCl>>Cc1ccccc1COc1cc(-n2cnc3ccccc32)sc1C(=O)NC(C)C",
        "output": "736"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CCCC1=O.Cc1ccc(S(=O)(=O)O)cc1.O.O=C(NCC12CC3CC(CC(C3)C1)C2)c1c(Cl)ccc2nc(Cl)ccc12.O=C(O)C1(c2ccccc2)CCNCC1.O=C([O-])[O-].[K+].[K+]>>O=C(NCC12CC3CC(CC(C3)C1)C2)c1c(Cl)ccc2nc(N3CCC(C(=O)O)(c4ccccc4)CC3)ccc12",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.COCCN1C[C@@H](c2ccc(F)c(F)c2)[C@H](NC(=O)Nc2c(Br)c(C3CCNCC3)nn2-c2ccccc2)C1.CS(=O)(=O)Cl.Cl.Cl.ClCCl>>COCCN1C[C@@H](c2ccc(F)c(F)c2)[C@H](NC(=O)Nc2c(Br)c(C3CCN(S(C)(=O)=O)CC3)nn2-c2ccccc2)C1",
        "output": "584"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(CC)CC.Cc1ccccc1.O=C(Cl)c1ccc(Br)cc1>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(Br)cc2)CC1",
        "output": "201"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(N(C(=O)c2cnc(-c3ccc(S(C)(=O)=O)cc3)nc2)C2CC2)CC1.O=C(c1cnc(-n2ccnc2)nc1)N(C1CCNCC1)C1CC1>>CS(=O)(=O)c1ccc(-c2ncc(C(=O)N(C3CCNCC3)C3CC3)cn2)cc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CBr)c1.Oc1ccccc1.[H-].[Na+]>>CCOC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2COc2ccccc2)c1",
        "output": "127"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)O)CC2)nc1CF.NS(=O)(=O)Cc1cccc(Cl)c1>>CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3cccc(Cl)c3)CC2)nc1CF",
        "output": "644"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCC(N2CCNCC2)C1.CN(C)C=O.N#Cc1ccnc(Cl)c1>>N#Cc1ccnc(N2CCN(C3CCCC3)CC2)c1",
        "output": "220"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O.C[O-].Cl.Cl.NCC(F)(F)C(=O)O.O.[Na+]>>N#Cc1nc(C(=O)NCC(F)(F)C(=O)O)c(O)c2ccc(Oc3ccccc3)cc12",
        "output": "487"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.Cl.Cl.NC1CCN(CCN2CCCCCC2)CC1.O=C(O)c1cc2c(Oc3ccccc3)cccc2[nH]1>>O=C(NC1CCN(CCN2CCCCCC2)CC1)c1cc2c(Oc3ccccc3)cccc2[nH]1",
        "output": "137"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1ccc(C2(N)CC2)cc1.Cl.O=C(O)c1cc(Cl)cnc1N1CC(Oc2cccc(C(F)(F)F)c2)C1>>COC(=O)c1ccc(C2(NC(=O)c3cc(Cl)cnc3N3CC(Oc4cccc(C(F)(F)F)c4)C3)CC2)cc1",
        "output": "790"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.COc1ccc(C(=O)O)cc1OC.Cc1ccccc1.O.O=S(Cl)Cl.[Ca+2].[Cl-].[Cl-]>>COc1ccc(C(=O)Cl)cc1OC",
        "output": "3"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C1CCN(S(=O)(=O)c2ccc(-c3nc4c(c(C5CCCCC5)nn4C)c(=O)[nH]3)c(OC)c2)CC1.CO.[Na+].[OH-]>>COc1cc(S(=O)(=O)N2CCC(C(=O)O)CC2)ccc1-c1nc2c(c(C3CCCCC3)nn2C)c(=O)[nH]1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(=O)(=O)Cl.C[Si](C)(C)CCOCn1ccc2c(-c3cnn([C@@H]4CC[C@@H](O)CC4)c3)ncnc21.ClCCl>>C[Si](C)(C)CCOCn1ccc2c(-c3cnn([C@@H]4CC[C@@H](OS(C)(=O)=O)CC4)c3)ncnc21",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.O=C(CN1CCC(c2ccc(F)cc2)(c2ccc(F)cc2)C1=O)N1CC2(CCN(Cc3ccccc3)CC2)C1>>O=C(CN1CCC(c2ccc(F)cc2)(c2ccc(F)cc2)C1=O)N1CC2(CCNCC2)C1",
        "output": "84"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CC1CCNCC1.ClC(Cl)Cl.O=[N+]([O-])c1cc(CO)ccc1F>>CC1CCN(c2ccc(CO)cc2[N+](=O)[O-])CC1",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C[O-].Cc1c(Cl)nc2ccc(Br)cc2c1Cl.Cc1ccccc1.ClCCl.[Na+]>>COc1nc2ccc(Br)cc2c(Cl)c1C",
        "output": "433"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.Nc1cc2ccccc2cc1C(=O)O.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>Nc1cc2ccccc2cc1CO",
        "output": "72"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cn1cc(Cl)c(CN)n1.O=C(O)c1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1>>Cn1cc(Cl)c(CNC(=O)c2cnc(OCC(F)(F)F)c(-c3ccc(Cl)cc3)c2)n1",
        "output": "674"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc2oc(-c3cc(N)ccc3C)nc2c1.O=C(Cl)c1cccnc1Cl>>Cc1ccc2oc(-c3cc(NC(=O)c4cccnc4Cl)ccc3C)nc2c1",
        "output": "642"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.Cc1[nH]c2c(-c3cc(F)ccc3OCC3CC3)ccnc2c1C(=O)NC1CCNCC1.Cl>>CC(=O)N1CCC(NC(=O)c2c(C)[nH]c3c(-c4cc(F)ccc4OCC4CC4)ccnc23)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1c(Cl)cccc1S(=O)(=O)Cl.ClCCl.Nc1ccc2nccnc2c1.O=C([O-])O.[Na+].c1ccncc1>>Cc1c(Cl)cccc1S(=O)(=O)Nc1ccc2nccnc2c1",
        "output": "68"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCC(OC2CCNCC2)C1.CC(=O)N(C)C.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccn1>>O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccn1)N1CCC(OC2CCCC2)CC1",
        "output": "605"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)N(C)C.COc1cc2c(Nc3cc(CC(=O)O)[nH]n3)ncnc2cc1OCCCCl.Cl.OCC1CCNCC1>>COc1cc2c(Nc3cc(CC(=O)O)[nH]n3)ncnc2cc1OCCCN1CCC(CO)CC1",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCNc1cc2nc[nH]c(=O)c2cc1[N+](=O)[O-].O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+]>>CCNc1cc2ncnc(Cl)c2cc1[N+](=O)[O-]",
        "output": "14"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)NC(C)C.COC(=O)Cc1ccccc1O.Cl.ClCCl.O=C1CCC(=O)N1Br>>COC(=O)Cc1cccc(Br)c1O",
        "output": "4"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=C(O)C=Cc1ccc(Cl)c(F)c1.[Br-].[Br-].[Zn+2]>>O=C(O)CCc1ccc(Cl)c(F)c1",
        "output": "344"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)CI.CN(C)C=O.Cn1c(=O)cc[nH]c1=O.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)Cn1ccc(=O)n(C)c1=O",
        "output": "326"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cn1c(=O)[nH]c2cc(C(=O)O)ccc21.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)CC[C@@H]1NCCC[C@H]21>>Cn1c(=O)[nH]c2cc(C(=O)N3CCC[C@@H]4c5ccccc5CC[C@@H]43)ccc21",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)O)c(OC)cc3C)c(F)c12.Cc1cnc(C2(N)CC2)nc1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5ncc(C)cn5)CC4)c(OC)cc3C)c(F)c12",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.Cc1ccc2cccc(O)c2n1.O.O=[Se]=O>>O=Cc1ccc2cccc(O)c2n1",
        "output": "619"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.CSCn1ccc2cnc(C(=O)OC(C)(C)C)cc21.O.O=S([O-])OO.[K+]>>CC(C)(C)OC(=O)c1cc2c(ccn2CS(C)(=O)=O)cn1",
        "output": "847"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC#CCOc1ccc(C(=O)Cl)cc1.CCN(CC)CC.COC(=O)C(CN)(C(=O)OC)N1CCN(C(=O)OC(C)(C)C)CC1>>CC#CCOc1ccc(C(=O)NCC(C(=O)OC)(C(=O)OC)N2CCN(C(=O)OC(C)(C)C)CC2)cc1",
        "output": "271"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.COc1cccc(CCN)c1.ClCCl.O.O=C(O)C1CCN(C(=O)c2cc3ccccc3n2Cc2ccc(Cl)cc2)CC1.On1nnc2ccccc21>>COc1cccc(CCNC(=O)C2CCN(C(=O)c3cc4ccccc4n3Cc3ccc(Cl)cc3)CC2)c1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c2cc(C(F)(F)F)nn12.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.O=S([O-])([O-])=S.[Na+].[Na+]>>COc1ccc(C(=O)Cc2c(Cl)c[n+]([O-])cc2Cl)c2cc(C(F)(F)F)nn12",
        "output": "262"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CNC1.CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccccc3)CC2)nc1SCC(=O)O>>CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccccc3)CC2)nc1SCC(=O)N1CCC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCCCCCBr.O=C(O)/C=C/c1ccc(O)cc1.O=C(O)CC(=O)O>>CCCCCCCCCCCCOc1ccc(C=CC(=O)O)cc1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NC1CCNC1.CC(Cl)Cl.CCN(C(C)C)C(C)C.Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2nc(Cl)ncc2c1.ClCCl>>Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2nc(N3CCC(NC(=O)OC(C)(C)C)C3)ncc2c1",
        "output": "36"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(C)c1nc(N[C@H]2CCC[C@H](N)C2)nc2ccccc12.ClCCCl.Cn1cc(C=O)c2ccccc21.O=C([O-])O.[Na+].[Na+]>>CN(C)c1nc(N[C@H]2CCC[C@H](NCc3cn(C)c4ccccc34)C2)nc2ccccc12",
        "output": "441"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCC1CCCC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccccc1.[Br-].[Na+].[OH-].c1cn[nH]c1>>c1cnn(CC2CCCC2)c1",
        "output": "577"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.O.O=S(=O)([O-])O.O=S(=O)(c1ccccc1)n1ccc2c(Cl)c(C(F)(F)F)cnc21.[K+]>>FC(F)(F)c1cnc2[nH]ccc2c1Cl",
        "output": "831"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C(=O)N(C4CC4)C4CC4)cnc23)c(F)c1.O.O.[Li]O>>O=C(O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(C(=O)N(C4CC4)C4CC4)cnc23)c(F)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1ccc2[nH]ncc2c1.O.[Na+].[OH-]>>O=C(O)c1ccc2[nH]ncc2c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)c1ccc(C(=O)Cl)cc1.Cc1c(N)cccc1B1OC(C)(C)C(C)(C)O1.O.O=C([O-])O.[Na+]>>Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1B1OC(C)(C)C(C)(C)O1",
        "output": "11"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)S(=O)(=O)c1ccc(N2CCNCC2)cc1.Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)O.F[P-](F)(F)(F)(F)F>>Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(S(=O)(=O)N(C)C)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)C1(NC(=O)c2cccc(C)c2C=CC2CC2)Cc2ccccc2C1.O.[K+].[OH-]>>Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1C=CC1CC1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)O.CC(C)(O)CON1C(C)(C)CC(=O)CC1(C)C.CC1(C)CC(O)CC(C)(C)N1O.N=O.OO>>CC(C)(O)CON1C(C)(C)CC(O)CC1(C)C",
        "output": "91"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCC1CC(=O)C2=C(C1)NC(C)=C(C#N)C2c1cc(N)c(O)c(Br)c1.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1cccc(CBr)c1.[I-].[K+].[K+].[K+]>>CCCC1CC(=O)C2=C(C1)NC(C)=C(C#N)C2c1cc(N)c(OCc2cccc([N+](=O)[O-])c2)c(Br)c1",
        "output": "127"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1nn(C)cc1Nc1ncc(Cl)c(NC2CC3CNCC3C2)n1.ClCCl.F[P-](F)(F)(F)(F)F.N#CCC(=O)O>>Cc1nn(C)cc1Nc1ncc(Cl)c(NC2CC3CN(C(=O)CC#N)CC3C2)n1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(C2COC2)CC1.ClCCl.O=C(O)C(F)(F)F>>C1CC(C2COC2)CCN1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(CN(CCc1ccccc1)C(=O)CCOCCc1ccc(Br)cc1)OCC.Cl.ClCCl>>O=CCN(CCc1ccccc1)C(=O)CCOCCc1ccc(Br)cc1",
        "output": "409"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1cc(NC(=O)C2CCCNC2)no1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.Cl.O=S(=O)(Cl)c1ccc(Cl)cc1>>CC(C)(C)c1cc(NC(=O)C2CCCN(S(=O)(=O)c3ccc(Cl)cc3)C2)no1",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrB(Br)Br.COc1ccc(-n2c(-c3cnoc3C)nc3ccccc32)cc1.ClCCl>>Cc1oncc1-c1nc2ccccc2n1-c1ccc(O)cc1",
        "output": "402"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COCOc1cc(OCOC)c(C(=O)N2Cc3ccccc3C2C(=O)OC)cc1Cl.O.O.[Li+].[OH-]>>COCOc1cc(OCOC)c(C(=O)N2Cc3ccccc3C2C(=O)O)cc1Cl",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)c1ccc(O)cc1.N#Cc1ccc(N(CCO)CC(F)(F)F)c(C(F)(F)F)c1>>CC(=O)c1ccc(OCCN(CC(F)(F)F)c2ccc(C#N)cc2C(F)(F)F)cc1",
        "output": "478"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ncccc1B(O)O.Nc1cnc(-c2ccc(Br)cc2F)cn1>>COc1ncccc1-c1ccc(-c2cnc(N)cn2)c(F)c1",
        "output": "899"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COc1cc(Oc2ccc([N+](=O)[O-])cn2)ccc1C.O.[Cl-].[Fe].[NH4+]>>COc1cc(Oc2ccc(N)cn2)ccc1C",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCl.O=C(c1ccc(F)cc1)N1CCC[C@H](O)C1.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)O[C@H]1CCCN(C(=O)c2ccc(F)cc2)C1",
        "output": "34"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)O.CC(C)(C)[O-].COc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)ccc1Nc1nc(Cl)cc2cn[nH]c(=O)c12.Nc1ccncc1Cl.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[K+].[Pd].[Pd]>>COc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)ccc1Nc1nc(Nc2ccncc2Cl)cc2cn[nH]c(=O)c12",
        "output": "434"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CNc1ccnc(N)c1.Cc1ccc(S(=O)(=O)O)cc1.O=C(CBr)c1ccccc1O>>CNc1ccn2cc(-c3ccccc3O)nc2c1",
        "output": "508"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Nc1ccc(S(=O)(=O)Nc2cc3c(cc2F)COB3O)cc1.CC(=O)O.Cl>>Nc1ccc(S(=O)(=O)Nc2cc3c(cc2F)COB3O)cc1",
        "output": "66"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCc1cc(-c2ccc3c(c2)CCCC3=O)ccc1OC.O.O=C1CCCc2cc(-c3ccc(O)cc3)ccc21>>CCc1cc(-c2ccc3c(c2)CCCC3=O)ccc1O",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCCCCCCCCCCCOCCCCCCC(F)(F)C(F)(F)F>>CS(=O)(=O)OCCCCCCCCCCCOCCCCCCC(F)(F)C(F)(F)F",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(NS(=O)(=O)C(F)(F)F)c1ncc(-c2ccc(N)cc2)s1.COC(=O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1.O=C=Nc1cc(F)cc(F)c1>>CC(C)(NS(=O)(=O)C(F)(F)F)c1ncc(-c2ccc(NC(=O)Nc3cc(F)cc(F)c3)cc2)s1",
        "output": "473"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O=[N+]([O-])c1ccc(F)c(-c2cccc(CO)c2)c1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCc1cccc(-c2cc([N+](=O)[O-])ccc2F)c1",
        "output": "193"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CO.O=c1[nH]cncc1-c1ccc(OCc2ccccc2)c(F)c1>>O=c1[nH]cncc1-c1ccc(O)c(F)c1",
        "output": "23"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccccc2C(=O)O)CC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.ClCCl.Nc1ccc(C(F)(F)F)cc1N.[Cl-].[Cl-].[NH4+]>>CC(C)(C)OC(=O)N1CCN(c2ccccc2C(=O)Nc2ccc(C(F)(F)F)cc2N)CC1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc2c(cc1OC)C(Cc1ccccc1)NCC2.Cc1ccccc1CN.O=C(Br)CBr>>COc1cc2c(cc1OC)C(Cc1ccccc1)N(CC(=O)NCc1ccccc1C)CC2",
        "output": "946"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1ccccc1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)c1ccc(-c2ccc3ccc4cc(B5OC(C)(C)C(C)(C)O5)cc5ccc2c3c45)cc1.CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.O.O=P([O-])([O-])[O-].[Br-].[K+].[K+].[K+].[Pd+2]>>CC(C)(C)c1ccc(-c2ccc3ccc4cc(-c5ccccc5)cc5ccc2c3c45)cc1",
        "output": "933"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(OCc3nc(CC(=O)OCC)co3)nc2s1.CO.Cl.[Na+].[OH-]>>CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(OCc3nc(CC(=O)O)co3)nc2s1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCCCCn1cc(C[C@H](NC(=O)OC(C)(C)C)C(=O)OCc2ccccc2)c2ccccc21.[C].[Pd]>>CCCCCn1cc(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)c2ccccc21",
        "output": "186"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Cc1cc(C(F)(F)F)c(CN2C(=O)c3ccccc3C2=O)c(=O)n1C.NN.O>>Cc1cc(C(F)(F)F)c(CN)c(=O)n1C",
        "output": "242"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCCC.CCCCCNC(=O)N(C)c1cccc(Br)c1.COB(OC)OC.[Li]C.[Li]C(C)(C)C>>CCCCCNC(=O)N(C)c1cccc(B(O)O)c1",
        "output": "789"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[C@@H]1CN(c2ncc(CO)cc2Cl)CCN1c1nc2cc(C(F)(F)F)cc(N)c2[nH]1.O=C(O)c1ccc(Cl)cc1>>C[C@@H]1CN(c2ncc(CO)cc2Cl)CCN1c1nc2cc(C(F)(F)F)cc(NC(=O)c3ccc(Cl)cc3)c2[nH]1",
        "output": "759"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CCO.CCOC(=O)Cl.CCOC(C)=O.COC(=O)c1ccc(I)c(OC)c1.[BH4-].[Na+].[Na+].[OH-]>>COc1cc(CO)ccc1I",
        "output": "444"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.COC(=O)CN(Cc1ccccc1)CC(C)NC(=O)OC(C)(C)C.NCCc1ccc(F)cc1.Nc1cc(F)c(F)cc1C(=O)O.O.Oc1cccc2[nH]nnc12>>Nc1cc(F)c(F)cc1C(=O)NCCc1ccc(F)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.Cc1ccc(C#N)c(=O)[nH]1.O=C(O)C(F)(F)F.O=C1CCC(=O)N1I>>Cc1[nH]c(=O)c(C#N)cc1I",
        "output": "783"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Cc1cccc(N)n1.O=C1CCC(=O)N1Cl>>Cc1nc(N)ccc1Cl",
        "output": "743"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCC.Cl.Fc1cccc2[nH]ccc12.[BH4-].[Cl-].[Cl-].[Na+].[Na+].[OH-].[Zn+2]>>Fc1cccc2c1CCN2",
        "output": "672"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CC(O)C1.Fc1ccc(C(F)(F)F)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CC(Oc2ccc(C(F)(F)F)cc2)C1",
        "output": "485"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CC[C@@H](N)CC1.Cc1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)O)c(C)n(COCC[Si](C)(C)C)c23)c1>>Cc1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)N[C@@H]4CC[C@H](NC(=O)OC(C)(C)C)CC4)c(C)n(COCC[Si](C)(C)C)c23)c1",
        "output": "737"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CNCc1c(C)cc(C)nc1O.ClCCl.F[P-](F)(F)(F)(F)F.N#Cc1c(Oc2ccc(C(=O)O)cc2Cl)cccc1-c1ccncn1.O>>Cc1cc(C)c(CN(C)C(=O)c2ccc(Oc3cccc(-c4ccncn4)c3C#N)c(Cl)c2)c(O)n1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.ClCCl.O.O=[N+]([O-])c1ccc2c(c1)CCN2>>CC(C)(C)OC(=O)N1CCc2cc([N+](=O)[O-])ccc21",
        "output": "827"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cc2nc(Cc3ccccc3)n(Cc3ccc(-c4ccccc4C(=O)OC(C)(C)C)cc3)c2cc1C.ClCCl.O=C(O)C(F)(F)F>>Cc1cc2nc(Cc3ccccc3)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2cc1C",
        "output": "752"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCI.CCOC(=O)c1cnc(Cl)c2cc[nH]c12.CN(C)C=O.[H-].[Na+]>>CCOC(=O)c1cnc(Cl)c2ccn(CC)c12",
        "output": "302"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cl.Nc1cccc(NC(=O)Nc2ccccc2Br)c1O.O.O=[N+]([O-])[O-].[N-]=[N+]=[N-].[Na+].[Na+]>>[N-]=[N+]=Nc1cccc(NC(=O)Nc2ccccc2Br)c1O",
        "output": "189"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CI.CN(C)C=O.O=C([O-])[O-].O=C1NCCc2[nH]c(I)cc21.[Cs+].[Cs+]>>Cn1c(I)cc2c1CCNC2=O",
        "output": "191"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)NS(=O)(=O)c1ccc(-c2cccc(-c3nc(-c4ccc(Cl)c(Cl)c4)cc(C(F)(F)F)n3)c2)s1.ClCCl.O=C(O)C(F)(F)F>>NS(=O)(=O)c1ccc(-c2cccc(-c3nc(-c4ccc(Cl)c(Cl)c4)cc(C(F)(F)F)n3)c2)s1",
        "output": "680"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc2c(c1)CC1(C2)OC(=O)Nc2ncccc21.O.O.[Li+].[OH-]>>O=C1Nc2ncccc2C2(Cc3ccc(C(=O)O)cc3C2)O1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)cn1.Cl.O=C([O-])O.[Na+]>>O=S(=O)(Nc1ccc2c(c1)B(O)OC2)c1ccc(O)nc1",
        "output": "408"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C(=O)O)cc1C12CC3CC(CC(C3)C1)C2.NCc1ccc(O)cc1O>>COc1ccc(C(=O)NCc2ccc(O)cc2O)cc1C12CC3CC(CC(C3)C1)C2",
        "output": "753"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC(C)I.ClCCl.N#Cc1cccc(O)c1.O=C([O-])[O-].O=C([O-])[O-].[Cs+].[Cs+].[K+].[K+]>>CC(C)Oc1cccc(C#N)c1",
        "output": "318"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.ClCCl.Cn1nccc1CC(=O)NCc1ccc(F)c(F)c1Cl.O.O=C([O-])O.O=C1CCC(=O)N1Cl.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>Cn1ncc(Cl)c1CC(=O)NCc1ccc(F)c(F)c1Cl",
        "output": "856"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Clc1ncccn1.Oc1c(C2CCC2)ccc(-c2cnc3c(c2)OCCN3)c1F>>Fc1c(-c2cnc3c(c2)OCCN3)ccc(C2CCC2)c1Oc1ncccn1",
        "output": "542"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC1CCCN1.CCOC(=O)C1CCc2sc(-c3ccc(OCCCCl)cc3)nc21.ClCCl.[I-].[Na+]>>CCOC(=O)C1CCc2sc(-c3ccc(OCCCN4CCCC4C)cc3)nc21",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.ClCCCI.O.Oc1ccc2c(c1)OCO2.[Cl-].[H-].[Na+].[Na+]>>ClCCCOc1ccc2c(c1)OCO2",
        "output": "198"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(Cc2ccccc2)CC1.CC(Cl)OC(=O)Cl.ClCCl>>C=CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2ccc(OCCCOc3cccc(F)c3F)cc2)C(O)C1.COCCCN1C(=O)COc2ccc(CCl)cc21>>COCCCN1C(=O)COc2ccc(COC3CN(C(=O)OC(C)(C)C)CCC3c3ccc(OCCCOc4cccc(F)c4F)cc3)cc21",
        "output": "208"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "N#Cc1cc(Br)c2c(c1)cc1n2CCCNC1=O.OB(O)c1ccc(Cl)cc1F>>N#Cc1cc(-c2ccc(Cl)cc2F)c2c(c1)cc1n2CCCNC1=O",
        "output": "833"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CN(c1ccc2c(c1)nc(C(C)(F)F)n2CC1CCOCC1)S(=O)(=O)c1ccc([N+](=O)[O-])cc1.[Pd]>>CN(c1ccc2c(c1)nc(C(C)(F)F)n2CC1CCOCC1)S(=O)(=O)c1ccc(N)cc1",
        "output": "401"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COc1cc(Cl)nc(C(=O)O)c1.ClCCl.O.O=C(n1ccnc1)n1ccnc1.[NH4+].[OH-]>>COc1cc(Cl)nc(C(N)=O)c1",
        "output": "136"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCn1nc(C)c(OC)c1C1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>CCn1nc(C)c(OC)c1C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.C[C@]12CC[C@H]3[C@@H]([C@@H](O)C=C4C[C@@H](O)CC[C@@]43C)[C@@H]1[C@@H]1C[C@@H]1C2=O.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)O[C@H]1CC[C@@]2(C)C(=C[C@H](O)[C@H]3[C@@H]4[C@@H]5C[C@@H]5C(=O)[C@@]4(C)CC[C@@H]32)C1",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COc1cccc2c1CC(=O)N2C.ClC(Cl)Cl.ClCCl.O=C([O-])O.O=C1CCC(=O)N1Br.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>COc1c(Br)ccc2c1CC(=O)N2C",
        "output": "4"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CC[C@@H]2CNCC[C@@H]2C1.CCN(C(C)C)C(C)C.CN(C)C=O.COc1ccc2oc(C(=O)C(C)(C)C)c(CC(=O)O)c2c1.ClCCCl.On1nnc2ccccc21>>COc1ccc2oc(C(=O)C(C)(C)C)c(CC(=O)N3CC[C@@H]4CCCC[C@@H]4C3)c2c1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)CC1COc2ccc(C#CC(C)(C)O)cc2-c2nc(C(N)=O)sc21.[Li+].[OH-]>>CC(C)(O)C#Cc1ccc2c(c1)-c1nc(C(N)=O)sc1C(CC(=O)O)CO2",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.Nn1c(-c2ccccc2)nc2ccccc2c1=O.O=C(O)C1C2CC3CC(C2)CC1C3.O=S(Cl)Cl>>O=C(Nn1c(-c2ccccc2)nc2ccccc2c1=O)C1C2CC3CC(C2)CC1C3",
        "output": "459"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CC[C@@H](O)C1.COC(=O)C(O)(c1cccs1)c1cccs1.Cc1ccccc1>>CN1CC[C@@H](OC(=O)C(O)(c2cccs2)c2cccs2)C1",
        "output": "289"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.ClCCCI.O=C([O-])[O-].O=C(c1c[nH]c2ncccc12)C(F)(F)F.[Cs+].[Cs+]>>O=C(c1cn(CCCCl)c2ncccc12)C(F)(F)F",
        "output": "326"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)c1cccc(N)c1.CC(C)(C)c1cccc(NC(=O)c2ccc(Br)c(F)c2)c1.Cc1cc(Br)ccc1C(=O)O>>Cc1cc(Br)ccc1C(=O)Nc1cccc(C(C)(C)C)c1",
        "output": "50"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCO[C@@H](C)[C@@H](C)C(=O)O.O=C(Cl)C(=O)Cl>>CCCCO[C@@H](C)[C@@H](C)C(=O)Cl",
        "output": "56"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(=O)CC1.ClC(Cl)Cl.ClCCCl.O=C([O-])[O-].O=c1[nH]c2ccccc2n1C1CCNCC1.[Na+].[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)CCC(C)(C)c2cc(-c3cc(-c4ccc(CO)cc4)ccc3-c3ccccc3)ccc21.ClCCl.[Mn+2].[O-2]>>CC1(C)CCC(C)(C)c2cc(-c3cc(-c4ccc(C=O)cc4)ccc3-c3ccccc3)ccc21",
        "output": "179"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)N=NC(=O)OCC.COC(=O)CCc1ccc(O)cc1.Cc1cccc(C)c1Cc1cccc(CO)c1.Cc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)CCc1ccc(OCc2cccc(Cc3c(C)cccc3C)c2)cc1",
        "output": "347"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O.CCO.O=C(COc1ccc(CCCCNC(=O)OCc2ccccc2)cc1)Nc1ccccc1.[Pd]>>NCCCCc1ccc(OCC(=O)Nc2ccccc2)cc1",
        "output": "574"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCC1CC1.ClCCl.c1ccc2c(c1)CC[C@@H]1CNCC[C@@H]21>>c1ccc2c(c1)CC[C@@H]1CN(CC3CC3)CC[C@@H]21",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCOc1ccc(F)c2c(=O)c(-c3ccc(OC)cc3)cn(CC(=O)NC3CCN(C(=O)OC(C)(C)C)CC3)c12.CCO.CCOC(C)=O.Cl>>CCCOc1ccc(F)c2c(=O)c(-c3ccc(OC)cc3)cn(CC(=O)NC3CCNCC3)c12",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CCCCCC.CCOC(C)=O.CO.COc1cccc2c1CC(NCCCCc1c[nH]c3ccc(F)cc13)CO2.O=C1CCC1.[BH3-]C#N.[Na+]>>COc1cccc2c1CC(N(CCCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O=C(OCc1ccccc1)c1nc2c3ccccc3nc(=O)n2[nH]1.[H][H].[Pd]>>O=C(O)c1nc2c3ccccc3nc(=O)n2[nH]1",
        "output": "291"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1NCCn2c(-c3cncnc3)nnc21.O=C(O)c1cc2ncc(Br)cn2n1>>CC1c2nnc(-c3cncnc3)n2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "663"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN1CCOCC1.CNOC.CO.COc1nc(OC)nc([N+]2(C)CCOCC2)n1.Cc1ccc(C(=O)O)cn1.Cl.[Cl-]>>CON(C)C(=O)c1ccc(C)nc1",
        "output": "879"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.OCCSCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.c1ccncc1>>CC(=O)OCCSCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F",
        "output": "254"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cn1c(CC2CCCCN2C(=O)OC(C)(C)C)nc2cc(F)c(F)cc21.O=C(O)C(F)(F)F>>Cn1c(CC2CCCCN2)nc2cc(F)c(F)cc21",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CSc1nc(-c2ccc3ccc(-c4ccccc4)nc3c2F)c2c(N)nccn12.ClCCl.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nc(-c2ccc3ccc(-c4ccccc4)nc3c2F)c2c(N)nccn12",
        "output": "595"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)Oc1c(C(N)=O)n(C)c2ccc(OCc3ccccc3)cc12.CO.[Pd]>>CC(C)Oc1c(C(N)=O)n(C)c2ccc(O)cc12",
        "output": "23"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCC(CC)CBr.CN(C)C=O.COC(=O)c1ccc(O)cc1O.Cl.O=C([O-])[O-].[K+].[K+]>>CCCCC(CC)COc1ccc(C(=O)OC)c(O)c1",
        "output": "385"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CSC[C@@H](Cc2ccc([N+](=O)[O-])c(Br)c2)[C@@H]1O.ClCCl.O=C(O)C(F)(F)F>>N[C@H]1CSC[C@@H](Cc2ccc([N+](=O)[O-])c(Br)c2)[C@@H]1O",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc([C@H](C)N)cc1.O=C(O)Cn1nnc2c(F)cccc2c1=O>>Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1",
        "output": "599"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NC(=Nc1cccc(-c2ncccc2[N+](=O)[O-])c1)NC(=O)OC(C)(C)C.CCO.[Pd]>>CC(C)(C)OC(=O)NC(=Nc1cccc(-c2ncccc2N)c1)NC(=O)OC(C)(C)C",
        "output": "269"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(C=O)(COCC2CCC2)CC1.ClCCl.N[C@@H]1C[C@H]1c1ccccc1.[Na+]>>CC(C)(C)OC(=O)N1CCC(CN[C@@H]2C[C@H]2c2ccccc2)(COCC2CCC2)CC1",
        "output": "426"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(=O)(=O)c1cc(Br)ccc1C(=O)O.O=C(c1ccc(Cl)cc1)C1CCNCC1>>CS(=O)(=O)c1cc(Br)ccc1C(=O)N1CCC(C(=O)c2ccc(Cl)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)[C@@H](N)Cc1ccc(N(CCCl)CCCl)cc1.Cl.Cl>>N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC(Oc2ccc(I)cc2)C1.ClCCl.O=C(O)C(F)(F)F>>Ic1ccc(OC2CNC2)cc1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)C(C=C(Cl)Cl)C1C(=O)O.CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccccc1.FC(F)Oc1cccc(CBr)c1.O.[Br-].[K+].[OH-]>>CC1(C)C(C=C(Cl)Cl)C1C(=O)OCc1cccc(OC(F)F)c1",
        "output": "403"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(Cl)OC(=O)Cl.ClCCl.O=C1C2CN(Cc3ccccc3)CC2C(=O)N1Cc1ccccc1>>O=C1C2CNCC2C(=O)N1Cc1ccccc1",
        "output": "84"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OCc2cc([C@@H]3CN(CCc4ccc(O)cc4)C(=O)O3)ccc2O1.COC(=O)c1cccc(COCCO)c1.ClCCl.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1cccc(COCCOc2ccc(CCN3C[C@@H](c4ccc5c(c4)COC(C)(C)O5)OC3=O)cc2)c1",
        "output": "550"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClC(Cl)Cl.Clc1ccc(Br)cn1.NC(N)=O.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=S([O-])([O-])=S.OO.[Na+].[Na+]>>[O-][n+]1cc(Br)ccc1Cl",
        "output": "396"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(C(=O)OC)(c1ccc(Cl)cc1)n1ccc2c(NC(=O)OC(C)(C)C)cccc21.CO.Cl>>CCC(C(=O)OC)(c1ccc(Cl)cc1)n1ccc2c(N)cccc21",
        "output": "782"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(=O)C(C)(C)C1.CCCCCC.Fc1ccc(Br)cc1.[Li]CCCC>>CC(C)(C)OC(=O)N1CCC(O)(c2ccc(F)cc2)C(C)(C)C1",
        "output": "321"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)O.CCOC(C)=O.Cc1nc(NCCCc2cccc(O)c2)nc(C)c1C(=O)N[C@@H](CNC(=O)c1cccs1)C(=O)O.O=S(Cl)Cl>>Cc1nc(NCCCc2cccc(O)c2)nc(C)c1C(=O)N[C@@H](CNC(=O)c1cccs1)C(=O)OC(C)C",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CN1CCN(CCCN)CC1.Cc1cccc(-c2nc3ccccn3c2-c2ccnc(S(C)(=O)=O)n2)n1>>Cc1cccc(-c2nc3ccccn3c2-c2ccnc(NCCCN3CCN(C)CC3)n2)n1",
        "output": "629"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CO.COc1ccc(N2CCN(c3ccc(-n4ccn(C)c4=O)cc3)CC2)cc1.ClCCl.O.[NH4+].[OH-]>>Cn1ccn(-c2ccc(N3CCN(c4ccc(O)cc4)CC3)cc2)c1=O",
        "output": "402"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClC(Cl)Cl.ClCCl.OCc1ccnc(F)c1>>CS(=O)(=O)OCc1ccnc(F)c1",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC/C=C\\CCC(O)CC/C=C\\CC.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC/C=C\\CCC(CC/C=C\\CC)OS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COc1ccccc1S(=O)(=O)N(Cc1ccc(-c2cccc(C#N)c2)cc1)Cc1ccc(CP(=O)(OF)OF)c(Cl)c1.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>COc1ccccc1S(=O)(=O)N(Cc1ccc(-c2cccc(-c3nn[nH]n3)c2)cc1)Cc1ccc(CP(=O)(OF)OF)c(Cl)c1",
        "output": "390"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCC1CCCCC1.CN(C)C=O.O.O=C(NC(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1ccc(O)cc1)c1cccc2c1C=CCCC2.O=C([O-])[O-].[K+].[K+]>>O=C(NC(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1ccc(OCC2CCCCC2)cc1)c1cccc2c1C=CCCC2",
        "output": "75"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cnccc1NC(=O)c1cc(Br)cnc1N.OB(O)c1ccc(-n2cccn2)cc1>>Cc1cnccc1NC(=O)c1cc(-c2ccc(-n3cccn3)cc2)cnc1N",
        "output": "833"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)c1ccncc1.COc1cccc(S(=O)(=O)Cl)c1.Nc1cccc2cccnc12>>COc1cccc(S(=O)(=O)Nc2cccc3cccnc23)c1",
        "output": "554"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cccc(B(O)O)c1.Cc1cc(N)cc([N+](=O)[O-])c1Br.Cc1ccccc1.O=C([O-])[O-].[Na+].[Na+]>>CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cccc(-c2c(C)cc(N)cc2[N+](=O)[O-])c1",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCOc1ccc(CBr)c(Cl)c1.CCOC(=O)CCCCCOc1cccc(N)c1NC(C)=O.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCCCCOc1ccc(CNc2cccc(OCCCCCC(=O)OCC)c2NC(C)=O)c(Cl)c1",
        "output": "272"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(C)=O.N#Cc1cc([N+](=O)[O-])ccc1Cl.O.Oc1ccc(Oc2ccccc2)cc1.[Na+].[OH-]>>N#Cc1cc([N+](=O)[O-])ccc1Oc1ccc(Oc2ccccc2)cc1",
        "output": "299"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Cl.Nc1ccc(N2CCOCC2)c([N+](=O)[O-])c1>>COc1ccc2nc(Nc3ccc(N4CCOCC4)c([N+](=O)[O-])c3)c3n[nH]cc3c2c1",
        "output": "998"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.CCN(CC)CC.Cc1noc(-c2ccc(Br)cc2)c1CNCCc1ccccc1>>CC(=O)N(CCc1ccccc1)Cc1c(C)noc1-c1ccc(Br)cc1",
        "output": "125"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.Cc1cc(=O)oc2cc(N)ccc12.Cc1cccc(C)c1-c1nc2ccc(C(=O)Cl)cc2[nH]1.Cl.O>>Cc1cccc(C)c1-c1nc2ccc(C(=O)Nc3ccc4c(C)cc(=O)oc4c3)cc2[nH]1",
        "output": "11"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCNCC1.COC(=O)c1c(Cl)nc2cc3c(cc2c1CCl)OCCO3.ClCCl.O>>COC(=O)c1c(Cl)nc2cc3c(cc2c1CN1CCN(C)CC1)OCCO3",
        "output": "156"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.COc1cc2[nH]c(Cl)nc(=O)c2c(C)c1OC.O=C(N1CCCNCC1)N1CCOCC1.[Br-].[K+]>>COc1cc2[nH]c(N3CCCN(C(=O)N4CCOCC4)CC3)nc(=O)c2c(C)c1OC",
        "output": "36"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.Cc1ccc(C(=O)C[N+](=O)[O-])cc1.Cc1ccc(C(C)C)cc1.Cc1ccc(S(=O)(=O)[N-][C@@H](c2ccccc2)[C@@H](N)c2ccccc2)cc1.O.O=CO.[Cl-].[Ru+2]>>Cc1ccc(C(O)C[N+](=O)[O-])cc1",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1ccc([N+](=O)[O-])cc1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.OCCO>>CC1(c2ccc([N+](=O)[O-])cc2)OCCO1",
        "output": "93"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)CCc1ccc(C(F)(F)F)nc1.Cl.ClCCl.O.O.[Li+].[OH-]>>O=C(O)CCc1ccc(C(F)(F)F)nc1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(=O)Cl.O=C([O-])[O-].Oc1ccc(Br)cc1.[K+].[K+]>>CC(=O)Oc1ccc(Br)cc1",
        "output": "111"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CCN(CCN(CC)CCCCC(C)C)c1ccc([N+](=O)[O-])cc1.CCO.Cl[Sn]Cl.O.O>>C=CCN(CCN(CC)CCCCC(C)C)c1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCBr.CN(C)C=O.COC(C)(C)C.Cc1ccc(O)cc1[N+](=O)[O-].O=C([O-])[O-].[Na+].[Na+]>>CCCCOc1ccc(C)c([N+](=O)[O-])c1",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)c1cc(Br)ccc1O.CCO.CCOCC.Cl.O.O=Cc1ccc(OC(F)(F)F)cc1.[Na+].[OH-]>>O=C(/C=C/c1ccc(OC(F)(F)F)cc1)c1cc(Br)ccc1O",
        "output": "656"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCNc1c([N+](=O)[O-])cnc2ccccc12.CCO.[Pd]>>CCNc1c(N)cnc2ccccc12",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NCCCl)c2n1.Cl>>O=C(NCCCl)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)c[nH]c3=O)nc12",
        "output": "758"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc2cc(Oc3ncnc4cc(O)ccc34)ccc2[nH]1.OCCN1CCCCC1>>Cc1cc2cc(Oc3ncnc4cc(OCCN5CCCCC5)ccc34)ccc2[nH]1",
        "output": "478"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(Br)Br.COB(OC)OC.C[SiH](C)OC(C)(C)C.Cl.OCCc1ccc(Br)cc1.[Mg]>>OCCc1ccc(B(O)O)cc1",
        "output": "789"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.O=C(c1cc(Cl)ncn1)N1CCc2cc(Cl)ccc21.O=c1[nH]c2ncccc2n1C1CCNCC1>>O=C(c1cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)ncn1)N1CCc2cc(Cl)ccc21",
        "output": "162"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(=O)C(CCc1ccccc1)CC(=O)c1ccc(Br)cc1.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)C(CCc1ccccc1)CC(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1",
        "output": "942"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=C(O)c1cccc2cc(Cl)ncc12.O=S(Cl)Cl>>COC(=O)c1cccc2cc(Cl)ncc12",
        "output": "33"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.COC(=O)CCN.Cc1cc2ccccc2nc1NC(c1ccc(C(=O)O)cc1)C1CC(C)(C)C1.Cl.Cl.ClCCl>>COC(=O)CCNC(=O)c1ccc(C(Nc2nc3ccccc3cc2C)C2CC(C)(C)C2)cc1",
        "output": "821"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCS(=O)(=O)Cl.ClCCl.NCc1ccncc1Br.O=C([O-])[O-].[Na+].[Na+]>>CCS(=O)(=O)NCc1ccncc1Br",
        "output": "493"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CNC[C@H](C)Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12.COCC(=O)O>>COCC(=O)N(C)C[C@H](C)Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C1(c2ccccc2Cl)C(=O)N(Cc2ccc(C(=O)OC(C)(C)C)cc2)c2ccc(Cl)cc21.ClCCl.O=C(O)C(F)(F)F>>CN(C)C1(c2ccccc2Cl)C(=O)N(Cc2ccc(C(=O)O)cc2)c2ccc(Cl)cc21",
        "output": "752"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COC(=O)c1coc(-c2ccccc2)n1.Cl.[Na+].[OH-]>>O=C(O)c1coc(-c2ccccc2)n1",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN.COc1cc2c(c(-c3cccc(C)c3C)c1)OC(COS(=O)(=O)c1ccc(C)cc1)C2>>CNCC1Cc2cc(OC)cc(-c3cccc(C)c3C)c2O1",
        "output": "853"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)NC(=O)[C@H]1CC[C@@H](Nc2cc(Cl)ncc2N)CC1.COCCOc1cc(N[C@H]2CC[C@@H](C(=O)NC(C)C)CC2)c([N+](=O)[O-])cn1>>COCCOc1cc(N[C@@H]2CC[C@H](C(=O)NC(C)C)CC2)c(N)cn1",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CCC1(c2ccccc2)C(=O)NC(=O)NC1=O.C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O.O=[N+]([O-])O>>C[C@]12CC[C@@H]3c4ccc(O)c([N+](=O)[O-])c4CC[C@H]3[C@@H]1CCC2=O",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCc1nc2ccc(C(=O)O)cc2n1Cc1ccccc1Cl.CCN(CC)CC.CN(C)C=O.CN(C)c1ccc(CN)cc1.Cl.ClCCl.O=C(Cl)C(=O)Cl>>CCCc1nc2ccc(C(=O)NCc3ccc(N(C)C)cc3)cc2n1Cc1ccccc1Cl",
        "output": "753"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CO.CO.Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cc4c(cc23)CN(C2CN(C(=O)OC(C)(C)C)CC2C(C)(C)C)C(=O)N4)ccn1.N>>Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cc4c(cc23)CN(C2CNCC2C(C)(C)C)C(=O)N4)ccn1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)Cn1nc(C(F)F)cc1C(F)F.O=C([O-])O.Oc1cccc(Cl)c1C1CC(c2csc(C3CC[NH2+]CC3)n2)=NO1.[Cl-].[Na+]>>O=C(Cn1nc(C(F)F)cc1C(F)F)N1CCC(c2nc(C3=NOC(c4c(O)cccc4Cl)C3)cs2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(C)=O.CNC.CSc1ccc(-c2cc(C(=O)O)nn2-c2ccc(F)cc2)cc1.Cl.O=C([O-])[O-].O=C(n1ccnc1)n1ccnc1.[K+].[K+]>>CSc1ccc(-c2cc(C(=O)N(C)C)nn2-c2ccc(F)cc2)cc1",
        "output": "663"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)C(=O)Cl.Clc1ccc2c(c1)CNCc1nnc(C3CCN(c4ncccn4)CC3)n1-2>>CC(C)(C)C(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ncccn3)CC2)C1",
        "output": "240"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc(C=O)cc2c1OC(C)(C)C2.Cl.NO.O=CO.[K+].[OH-]>>COc1cc(C#N)cc2c1OC(C)(C)C2",
        "output": "453"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2c3CCCC2)cc1.O=S(=O)(Cl)Cc1c(Cl)cccc1Cl>>O=C1CC(=O)N(c2ccc(NS(=O)(=O)Cc3c(Cl)cccc3Cl)cc2)c2ccc3c(c2N1)CCCC3",
        "output": "194"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnccc1Br.COc1cccc(F)c1B(O)O>>COc1cccc(F)c1-c1ccncc1N(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "872"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC(c1ccc(C(=O)O)cc1)C(C(=O)OC(C)(C)C)c1ccc(Cl)cc1.CCN(C(C)C)C(C)C.COC(=O)CCN.ClCCCl.ClCCl.On1nnc2ccccc21>>CCCC(c1ccc(C(=O)NCCC(=O)OC)cc1)C(C(=O)OC(C)(C)C)c1ccc(Cl)cc1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl.O.[K+].[OH-]>>O=C(O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=O.COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCNCC3)c12.Cl.Cl>>CCNC(=O)N1CCC(n2c(=O)n(-c3cccc(Cl)c3)c(=O)c3cnc4c(OC)cccc4c32)CC1",
        "output": "437"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)N1C(=O)NC(C)=C(C(=O)O)C1c1cccc(Cl)c1.Cl.ClCCl.NCCC(c1ccccc1)c1ccccc1>>CCOC(=O)N1C(=O)NC(C)=C(C(=O)NCCC(c2ccccc2)c2ccccc2)C1c1cccc(Cl)c1",
        "output": "549"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(C)S(=O)(=O)Nc1cccc(CO)c1F.O=C(O)c1ccccc1I(=O)=O>>CCN(C)S(=O)(=O)Nc1cccc(C=O)c1F",
        "output": "179"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1cccc(N2CCOCC2)c1>>O=S(=O)(Oc1cccc(N2CCOCC2)c1)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CI.CN(C)C=O.N#Cc1ccc2[nH]cc(C3=CCC4(CC3)OCCO4)c2c1.[H-].[Na+]>>Cn1cc(C2=CCC3(CC2)OCCO3)c2cc(C#N)ccc21",
        "output": "191"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CON=C1OC[C@@H](c2ccccc2)N1C1CCNCC1.Cc1nc(Oc2ccc(C(=O)NC3CC3)cc2)ccc1C=O.ClCCl.[Na+]>>CON=C1OC[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(Oc3ccc(C(=O)NC4CC4)cc3)nc2C)CC1",
        "output": "757"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Nc1cnc(OCC(F)(F)F)c(C2CCCC2)c1.O=C(O)c1cccnc1>>O=C(Nc1cnc(OCC(F)(F)F)c(C2CCCC2)c1)c1cccnc1",
        "output": "863"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CNCCC1(C)c1cccc(-c2c[nH]nn2)c1.CN(C)C=O.Cc1cccc(CCBr)c1.O=C([O-])O.[Na+]>>Cc1cccc(CCN2CCC(C)(c3cccc(-c4c[nH]nn4)c3)C(C)C2)c1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COc1ccc2ncc(F)c(CCN3CC(CNC(=O)OCc4ccccc4)C3)c2n1.[OH-].[OH-].[Pd+2]>>COc1ccc2ncc(F)c(CCN3CC(CN)C3)c2n1",
        "output": "574"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1c(CC)nc(C2CCCC2)c(COCc2cccc(C(F)(F)F)c2)c1-c1ccc(F)cc1.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[K+].[Li+].[OH-]>>CCc1nc(C2CCCC2)c(COCc2cccc(C(F)(F)F)c2)c(-c2ccc(F)cc2)c1CO",
        "output": "383"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrBr.CC(=O)O.O.O=C1CCCc2cc(O)ccc21>>O=C1CCCc2c1ccc(O)c2Br",
        "output": "98"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCNCC1.FC(F)c1nc2ccccc2n1-c1nc(Cl)nc(N2CCOCC2)n1>>CN1CCN(c2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1",
        "output": "214"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cncnc1-c1ccccc1.CO.[Na+].[OH-]>>O=C(O)c1cncnc1-c1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCN(CC(=O)O)CC1.NCc1ccncc1>>CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCN(CC(=O)NCc2ccncc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.COCCN.Cc1nc2c3c(c(C(=O)O)cn2c1C)CCC(c1ccccc1)C3.ClCCl.F[B-](F)(F)F.[Cl-].[NH4+]>>COCCNC(=O)c1cn2c(C)c(C)nc2c2c1CCC(c1ccccc1)C2",
        "output": "674"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cc([N+](=O)[O-])c(CC=O)cc23)ccn1.ClCCCl.NCc1ccc(F)cc1.[Na+]>>Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3cc([N+](=O)[O-])c(CCNCc4ccc(F)cc4)cc23)ccn1",
        "output": "627"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCO.CC[SiH](CC)CC.COC(C)(C)C.COc1ccc(C(=O)c2cc(Br)ccc2Cl)cc1.ClCCl.O=C([O-])O.[Na+]>>COc1ccc(Cc2cc(Br)ccc2Cl)cc1",
        "output": "181"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClC(Cl)Cl.O=C(NC[C@H]1CCCN(CC2CCCCC2)C1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1>>CS(=O)(=O)O[C@@H]1C[C@@H](C(=O)N2CCC[C@@H]2C(=O)NC[C@H]2CCCN(CC3CCCCC3)C2)N(C(=O)CC(c2ccccc2)(c2ccccc2)c2ccccc2)C1",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)[O-].CC1(C)C[C@H](Nc2nc(Nc3ccc(OCCO)c(Cl)c3)ncc2F)C[C@@H]2CCCN21.C[C@H](O)CO[Si](C)(C)C(C)(C)C.Cn1nnn(-c2cc([N+](=O)[O-])ccc2F)c1=O.[K+]>>C[C@@H](CO[Si](C)(C)C(C)(C)C)Oc1ccc([N+](=O)[O-])cc1-n1nnn(C)c1=O",
        "output": "485"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=C(c1ccccc1)c1cc(C)ccc1OCC1CCCN1C(=O)OC(C)(C)C.COc1ccc(C)cc1C(=O)c1ccccc1.O=C([O-])[O-].[K+].[K+].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C=C(c1ccccc1)c1cc(C)ccc1OCC1CCCN1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)c1c(C)nc(Cl)nc1C.COc1cccc(CCCN)c1>>CCOC(=O)c1c(C)nc(NCCCc2cccc(OC)c2)nc1C",
        "output": "544"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1ccc(C(O)CBr)cc1.CN>>CNCC(O)c1ccc(NC(C)=O)cc1",
        "output": "147"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC1CCNC1.CCN(C(C)C)C(C)C.CS(C)=O.Fc1ccc2c(Cl)ncnc2c1.O>>CC(C)(C)OC(=O)NC1CCN(c2ncnc3cc(F)ccc23)C1",
        "output": "296"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#Cc1ccc2c(c1)C(C)(C)CN(C1CC1)C2.C1CCOC1.CCCCCC.CCN(CC)CC.CCOC(=O)Cc1ccc(I)cc1F.CCOC(C)=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>CCOC(=O)Cc1ccc(C#Cc2ccc3c(c2)C(C)(C)CN(C2CC2)C3)cc1F",
        "output": "664"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(O)c1nc2ccccc2s1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.[Cl-].[Na+]>>CC(OS(C)(=O)=O)c1nc2ccccc2s1",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Fc1cc(OC2CCNCC2)cc(C(F)(F)F)c1.O.O=C(O)CNC(=O)c1cn(-c2ccccc2)cn1.On1nnc2ccccc21>>O=C(NCC(=O)N1CCC(Oc2cc(F)cc(C(F)(F)F)c2)CC1)c1cn(-c2ccccc2)cn1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1ccc2cc[nH]c2c1.Cc1ccccc1B(O)O>>Cc1ccccc1-c1ccc2cc[nH]c2c1",
        "output": "909"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCBr.CN(C)C=O.O.O=C([O-])[O-].O=Cc1ccc(O)c(Cl)c1.[K+].[K+]>>C=CCOc1ccc(C=O)cc1Cl",
        "output": "77"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CBr.Cc1cc2cc(F)ccc2[nH]1>>CCOC(=O)Cn1c(C)cc2cc(F)ccc21",
        "output": "310"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=Cc1ccc(C=C)cc1.C=Cc1ccccc1.CCN(CC)Cc1ccccc1.CO.ClCCl.Fc1cc(OCCCN2CCCCC2)ccc1N1CCNCC1.O=C(Cl)N1CCOCC1>>O=C(N1CCOCC1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2F)CC1",
        "output": "258"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COc1cc(OCCN2CCOCC2)ccc1[N+](=O)[O-].[Pd]>>COc1cc(OCCN2CCOCC2)ccc1N",
        "output": "202"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)OC(=O)N1CCC(Oc2ccc(CCO)cc2)CC1.ClCCl>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(CC=O)cc2)CC1",
        "output": "142"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC1(C)CCCC(C)(C)N1.COc1ccc(F)cc1.Cl.O=C=O.[Li]CCCC>>COc1ccc(F)c(C(=O)O)c1",
        "output": "387"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CO.COC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(S(=O)(=O)N2CCC(C=O)CC2)cc1.CS(=O)(=O)Nc1cc([C@@H](O)CN)ccc1O.[BH3-]C#N.[Na+]>>COC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(S(=O)(=O)N2CCC(CNC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1",
        "output": "426"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(=O)Cl.ClCCl.Clc1ccc2c(n1)O[C@H](c1ccccc1)CNC2>>CN(C)C(=O)N1Cc2ccc(Cl)nc2O[C@H](c2ccccc2)C1",
        "output": "258"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCCCOc1ccc(CO)cc1.ClC(Cl)Cl.O=S(Cl)Cl>>CCCCCCCCOc1ccc(CCl)cc1",
        "output": "81"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CC2CNCC1O2.CCN(CC)CC.CN(C)C=O.Cl.O=C(CCl)Nc1cc(C(=O)Nc2ccc(-c3ccccc3F)nc2)ccc1OC(F)(F)F.[I-].[K+]>>O=C(CN1CC2CCC(C1)O2)Nc1cc(C(=O)Nc2ccc(-c3ccccc3F)nc2)ccc1OC(F)(F)F",
        "output": "340"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1cccc(-c2nc(-c3cccnc3)no2)c1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].O=C1CCCN1.[Cs+].[Cs+].[Pd].[Pd]>>O=C1CCCN1c1cccc(-c2nc(-c3cccnc3)no2)c1",
        "output": "809"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1C(CO)CCC1(CO[Si](C)(C)C(C)(C)C)CO[Si](C)(C)C(C)(C)C.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCC2CCC(CO[Si](C)(C)C(C)(C)C)(CO[Si](C)(C)C(C)(C)C)N2C(=O)OC(C)(C)C)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCBr.CN(C)C=O.Cc1c(Br)cnn1CC1(O)CCCC(C)(C)C1.[H-].[Na+]>>C=CCOC1(Cn2ncc(Br)c2C)CCCC(C)(C)C1",
        "output": "120"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC(n2cc(-c3cnc(N)c4oc(-c5cccc6ccsc56)cc34)cn2)CC1.Cl.ClCCl>>Nc1ncc(-c2cnn(C3CCNCC3)c2)c2cc(-c3cccc4ccsc34)oc12",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1CCN(c2ccnc(Cl)c2)CC1.CC(C)(C)[O-].Cc1ccccc1.NC1CCCC1.[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)OC(=O)N1CCN(c2ccnc(NC3CCCC3)c2)CC1",
        "output": "70"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C[O-].Cn1nnn(-c2cccc(Br)c2CBr)c1=O.O=C([O-])O.[Na+].[Na+]>>COCc1c(Br)cccc1-n1nnn(C)c1=O",
        "output": "464"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCBr.CN(C)C=O.Cl.O.O=C(OCc1ccccc1)[C@H]1CCNC1.O=C([O-])[O-].[K+].[K+]>>CCN1CC[C@H](C(=O)OCc2ccccc2)C1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1ncc2[nH]c3ccccc3c2c1COC.ClCCl.ClI.II.c1ccncc1>>CCOC(=O)c1ncc2[nH]c3ccc(I)cc3c2c1COC",
        "output": "372"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1CCNCC1.Cc1ccc(Oc2ccc(Nc3ncnc4[nH]nc(OCCCl)c34)cc2Cl)cn1>>Cc1ccc(Oc2ccc(Nc3ncnc4[nH]nc(OCCN5CCN(C)CC5)c34)cc2Cl)cn1",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)[Si](C(C)C)(C(C)C)n1ccc2c(C(O)C3CC[C@H](N(Cc4ccccc4)Cc4ccccc4)C3)c(Cl)cnc21.ClCCl.O=S([O-])[O-].[Na+].[Na+]>>CC(C)[Si](C(C)C)(C(C)C)n1ccc2c(C(=O)C3CC[C@H](N(Cc4ccccc4)Cc4ccccc4)C3)c(Cl)cnc21",
        "output": "32"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.O.O=C(O)Cc1c(C(=O)O)n(-c2cccc(C(=O)O)c2)c2ccccc12.O=S(=O)(O)O>>CCOC(=O)Cc1c(C(=O)O)n(-c2cccc(C(=O)O)c2)c2ccccc12",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=Cc1ccccc1Br.O=c1cc(N2CCNCC2)nc[nH]1>>O=c1cc(N2CCN(Cc3ccccc3Br)CC2)nc[nH]1",
        "output": "567"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)O.CCCN.Nc1c(Cl)ncnc1Cl.O>>CCCNc1ncnc(Cl)c1N",
        "output": "110"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.C1COCCO1.CCOC(C)=O.Fc1ccc(F)c(C(Sc2ccc(Cl)cc2)c2cc(Cl)ncc2Cl)c1>>Fc1ccc(F)c(C(Sc2ccc(Cl)cc2)c2cc(N3CCOCC3)ncc2Cl)c1",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1CCn1ccc([N+](=O)[O-])n1>>NCCn1ccc([N+](=O)[O-])n1",
        "output": "242"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(O)c1cc(Br)ncc1F.ClC(Cl)Cl.[Mn+4].[O-2].[O-2]>>CC(=O)c1cc(Br)ncc1F",
        "output": "32"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C(=O)Cl.CCN(C(C)C)C(C)C.Cl.ClCCl.NCc1ccc(/C=C/C(=O)NC(c2cccc(C(F)(F)F)c2)C(F)(F)F)cc1C(F)(F)F>>CC(C)C(=O)NCc1ccc(/C=C/C(=O)NC(c2cccc(C(F)(F)F)c2)C(F)(F)F)cc1C(F)(F)F",
        "output": "206"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)CBr.CN(C)C=O.Cc1nc2cnc3ccc(O)cc3c2n1C.[H-].[Na+]>>CCOC(=O)COc1ccc2ncc3nc(C)n(C)c3c2c1",
        "output": "123"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C1COCCN1.CCCP(=O)=O.CCN(C(C)C)C(C)C.CCOC(C)=O.Cn1ncc(C(=O)O)c1C(=O)Nc1ccn2nc(-c3cccnc3)nc2c1>>Cn1ncc(C(=O)N2CCOCC2)c1C(=O)Nc1ccn2nc(-c3cccnc3)nc2c1",
        "output": "733"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.COc1ccc(CCO)cc1OC.Fc1cc(I)ccn1.O.[H-].[Na+]>>COc1ccc(CCOc2cc(I)ccn2)cc1OC",
        "output": "541"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4ccc(C5CCN(C[C@H](C)O)CC5)cc4)cnc32)cc1.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4ccc(C5CCNCC5)cc4)cnc32)cc1.Cl.O.[Li+].[OH-]>>Fc1cccc(Cn2cc(-c3c[nH]c4ncc(-c5ccc(C6CCNCC6)cc5)cc34)cn2)c1",
        "output": "949"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(-c2ncc(CN3CCCCC3)s2)cc1.Cl>>Nc1ccccc1NC(=O)c1ccc(-c2ncc(CN3CCCCC3)s2)cc1",
        "output": "782"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN1C(=O)CCC(C)(C)c2ccc(N)cc21.CN(CCC#N)c1cccc(F)c1Nc1nc(Cl)ncc1Cl>>CCN1C(=O)CCC(C)(C)c2ccc(Nc3ncc(Cl)c(Nc4c(F)cccc4N(C)CCC#N)n3)cc21",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=Cc1ccc(O)cc1.CS(C)=O.Cc1cc(CCl)c2ccccc2n1.O=C([O-])[O-].[Cs+].[Cs+].[I-].[Na+]>>C=Cc1ccc(OCc2cc(C)nc3ccccc23)cc1",
        "output": "49"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(=O)O.CCCCCCC=O.COc1ccc2c(c1)CCC1CCNC(=O)C(CC(C)NC(C)C)=C21.Cl.Cl.[BH3-]C#N.[Na+]>>CCCCCCCN(C(C)C)C(C)CC1=C2c3ccc(OC)cc3CCC2CCNC1=O",
        "output": "484"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(Sc2ccc(S(=O)(=O)Nc3ccc(Br)cc3)cc2[N+](=O)[O-])cc1.CCO.CCOC(C)=O.O.[Cl-].[Fe].[NH4+]>>CC(C)(C)OC(=O)Nc1ccc(Sc2ccc(S(=O)(=O)Nc3ccc(Br)cc3)cc2N)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CC(N)C(O)C1.CCCCO.CCN(C(C)C)C(C)C.Cc1cc(N(C)C)nc(Cl)n1.ClC(Cl)Cl.O=C([O-])O.[Na+]>>Cc1cc(N(C)C)nc(NC2CN(C(=O)OC(C)(C)C)CC2O)n1",
        "output": "544"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)Oc1ccc(-c2noc(-c3ccc(F)cc3Br)n2)cc1Cl.CCOC(C)=O.CN1CCCC1=O.N#C[Cu].O>>CC(C)Oc1ccc(-c2noc(-c3ccc(F)cc3C#N)n2)cc1Cl",
        "output": "531"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CCN(C)C.CCNCC.CCOC(C)=O.Cc1ncc(Br)cc1[N+](=O)[O-].Cl[Pd]Cl.I[Cu]I.O=C([O-])[O-].[Na+].[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1ncc(C#CCN(C)C)cc1[N+](=O)[O-]",
        "output": "719"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1ccc(C(=O)Nc2ccccc2NC(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CC(=O)Nc1ccc(C(=O)Nc2ccccc2N)cc1",
        "output": "782"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)CCOc1cc([N+](=O)[O-])cc(C(F)(F)F)c1.CO.[Pd]>>CN(C)CCOc1cc(N)cc(C(F)(F)F)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.ClCC1CO1.O=c1cc(-c2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)oc2ccc(O)cc12.[H-].[Na+]>>O=c1cc(-c2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)oc2ccc(OCC3CO3)cc12",
        "output": "15"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)/C=C/C1Cc2cc(Br)cc(Cl)c2O1.Cl.O.O>>O=C(O)/C=C/C1Cc2cc(Br)cc(Cl)c2O1",
        "output": "122"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COc1cc(OC)c(-c2cc3ccccc3n2C(=O)OC(C)(C)C)cc1C=O.ClCCl.[F-]>>COc1cc(OC)c(-c2cc3ccccc3[nH]2)cc1C=O",
        "output": "848"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)C1CCCN(C(=O)Cc2cccs2)C1.Cl.[Na+].[OH-]>>O=C(O)C1CCCN(C(=O)Cc2cccs2)C1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CC(C)(C)O.CN(C)C(=N)N(C)C.CN(C)C=O.ClCCl.Cl[Cu].Cl[Pd]Cl.Nc1cccc(Br)c1.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(O)C#Cc1cccc(N)c1",
        "output": "659"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C[C@H](N)CC(=O)OCc1ccccc1.Cl.Cl.Fc1ccccc1CBr.O=C(O)CCCCCCCOCc1ccccc1F.OCCCCCCCCO.OCCCCCCCCOCc1ccccc1F>>CN(C)C[C@@H](CC(=O)OCc1ccccc1)NC(=O)CCCCCCCOCc1ccccc1F",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOc1cc(OCc2ccccc2)ncc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO[Si](C)(C)C(C)(C)C)c(C(F)(F)F)c2)cc1F.ClCCl.O=C(O)C(F)(F)F>>CCOc1cc(OCc2ccccc2)ncc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(C(F)(F)F)c2)cc1F",
        "output": "708"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCc1nc(Cl)c(COCc2ccccc2)[nH]1.CS(=O)(=O)O.ClC(Cl)Cl.[Na+].[OH-]>>CCCCc1nc(Cl)c(CO)[nH]1",
        "output": "178"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc(C=Cc2ccc(Br)cc2)cc1.C=CC#N.CC(=O)[O-].CC(=O)[O-].CCCCN(CCCC)CCCC.Cc1ccccc1.[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#CC=Cc1ccc(C=Cc2ccc(Br)cc2)cc1",
        "output": "539"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.COC(=O)c1ccc([N+](=O)[O-])cc1C(F)(F)F.Cl[Sn](Cl)(Cl)Cl.O.O>>COC(=O)c1ccc(N)cc1C(F)(F)F",
        "output": "772"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CNC1.Cl.O.O=C([O-])[O-].O=S(=O)(Cl)c1ccc(F)cc1.[K+].[K+]>>O=S(=O)(c1ccc(F)cc1)N1CCC1",
        "output": "99"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCOC(=O)/C(=N\\OC)c1csc(NP(=O)(OCC)OCC)n1.O.[Na+].[OH-]>>CCOP(=O)(Nc1nc(/C(=N/OC)C(=O)O)cs1)OCC",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)OC(=O)Cl.CC1Cc2ccc(C3CCNCC3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1.Cl>>CC(C)OC(=O)N1CCC(c2ccc3c(c2)CN(c2cc(N4CCN(C)CC4)nc(N)n2)C(C)C3)CC1",
        "output": "219"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.C=CCc1c(OCCCOc2ccc(C(C)=O)c(O)c2CCC)ccc2oc(C(=O)OC)cc12.[Na+].[OH-]>>C=CCc1c(OCCCOc2ccc(C(C)=O)c(O)c2CCC)ccc2oc(C(=O)O)cc12",
        "output": "152"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CC2CCC1N2.CCN(CC)CC.Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)O)cc3c2[C@H](C)CN2CCC(=O)CC2)c1.Cl.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2[C@H](C)CN2CCC(=O)CC2)c1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=C(O)[C@H](O)CC1CCCC1.O=S(Cl)Cl>>COC(=O)[C@H](O)CC1CCCC1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN[C@H](C)CO.Oc1ccc(Nc2ncnc3cccc(F)c23)cc1Cl>>CN[C@H](C)COc1cccc2ncnc(Nc3ccc(O)c(Cl)c3)c12",
        "output": "958"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)Cc2cccc(CCCl)c2O1.CN(C)C=O.CON(C)C(=O)Nc1ccc(O)cc1.O.[H-].[Na+]>>CON(C)C(=O)Nc1ccc(OCCc2cccc3c2OC(C)(C)C3)cc1",
        "output": "74"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4nccn4CCO)cc2)CCN3CC(C)C)cc1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=S([O-])([O-])=S.[Na+].[Na+]>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4nccn4CCO)cc2)CCN3CC(C)C)cc1",
        "output": "500"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CN1CCOCC1.COC(=O)[C@@H](N)CC(C)C.ClCCCl.NCCCC[C@H](N)C(=O)O.On1nnc2ccccc21>>CC(C)C[C@H](N)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].O=[N+]([O-])c1ccc(Cl)c(COc2ccc(F)nc2)c1.[Fe+2].[Fe]>>Nc1ccc(Cl)c(COc2ccc(F)nc2)c1",
        "output": "706"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.c1cncc(CN2CCNCC2)c1>>CC(C)(C)OC(=O)NCC(=O)N1CCN(Cc2cccnc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1nc2c(c(=O)[nH]1)CCN(Cc1ccccc1)C2.O=P(Cl)(Cl)Cl>>Cc1nc(Cl)c2c(n1)CN(Cc1ccccc1)CC2",
        "output": "14"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCc1c(O)ccc(C(C)=O)c1O.CCCc1c(OCCCBr)ccc2c1OC(C)(CCC(=O)OC)CC2>>CCCc1c(OCCCOc2ccc3c(c2CCC)OC(C)(CCC(=O)OC)CC3)ccc(C(C)=O)c1O",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(CCn1ccc(-c2ccccc2)cc1=O)(C(=O)NOC1CCCCO1)S(C)(=O)=O.CO.Cl.ClCCl>>CCC(CCn1ccc(-c2ccccc2)cc1=O)(C(=O)NO)S(C)(=O)=O",
        "output": "915"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)CNC(=O)C(C)(C)c1ccc(Br)cc1.Nc1ccccc1B(O)O>>CC(C)CNC(=O)C(C)(C)c1ccc(-c2ccccc2N)cc1",
        "output": "837"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCS(=O)(=O)Cl.ClCCl.Nc1ccc2oc(-c3ccccc3)nc2c1.c1ccncc1>>CCCS(=O)(=O)Nc1ccc2oc(-c3ccccc3)nc2c1",
        "output": "194"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.C[C@@H]1Nc2ccccc2NC(=O)[C@H]1NC(=O)OC(C)(C)C.O=C1CCC(=O)N1Br.[Cl-].[NH4+]>>C[C@@H]1Nc2ccc(Br)cc2NC(=O)[C@H]1NC(=O)OC(C)(C)C",
        "output": "4"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCCN1CCNCC1.CS(=O)(=O)OCCc1ccc(Nc2ncc3c(n2)-c2ccccc2C(c2ccc(Cl)c(Cl)c2)C3)cc1>>COCCN1CCN(CCc2ccc(Nc3ncc4c(n3)-c3ccccc3C(c3ccc(Cl)c(Cl)c3)C4)cc2)CC1",
        "output": "496"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br.COc1ccc(CCCCn2ccnn2)cc1.CS(=O)(=O)O.[Na+].[OH-]>>Oc1ccc(CCCCn2ccnn2)cc1",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1cccc([N+](=O)[O-])c1C.[Pd]>>COC(=O)c1cccc(N)c1C",
        "output": "481"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccccc1-c1ncccc1CN.O=C([O-])O.S=C=Nc1cccc(Cl)c1Cl.[Na+]>>COc1ccccc1-c1ncccc1CNC(=S)Nc1cccc(Cl)c1Cl",
        "output": "113"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cn1ncc2c3oc(-c4ccccc4)c(-c4ccc(C5(NC(=O)OC(C)(C)C)CCC5)cc4)c(=O)c3ccc21.NC1(c2ccc(-c3c(-c4ccccc4)oc4ccc(F)cc4c3=O)cc2)CCC1>>Cn1ncc2c3oc(-c4ccccc4)c(-c4ccc(C5(N)CCC5)cc4)c(=O)c3ccc21",
        "output": "793"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1cc(Br)cc(Br)c1.CCc1c(Sc2cc(C)cc(C)c2)[nH]c(=O)[nH]c1=O>>CCc1c(Sc2cc(C)cc(C)c2)n(Cc2cc(Br)cc(Br)c2)c(=O)[nH]c1=O",
        "output": "389"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(=O)CC1CN=C(c2cc3cc(OC(F)(F)F)cc(N(C)S(=O)(=O)c4cccs4)c3[nH]2)S1.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>CN(c1cc(OC(F)(F)F)cc2cc(C3=NCC(CC(=O)O)S3)[nH]c12)S(=O)(=O)c1cccs1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CCN(CC)CC.NC1CC1.O=C(O)c1cn(-c2cccc(Br)c2)c2ncccc2c1=O>>O=C(NC1CC1)c1cn(-c2cccc(Br)c2)c2ncccc2c1=O",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)=O.O=C(N[C@@H]1C[C@H](C(=O)O)c2ccccc21)c1cccc(C(F)(F)F)c1.O=C([O-])O.[NH4+].c1ccncc1>>NC(=O)[C@H]1C[C@@H](NC(=O)c2cccc(C(F)(F)F)c2)c2ccccc21",
        "output": "313"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.CN(Cc1cc(-c2ccccc2Br)c(S(=O)(=O)c2cccnc2)s1)C(=O)OC(C)(C)C.O.[C-]#N.[C-]#N.[Pd].[Zn+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN(Cc1cc(-c2ccccc2C#N)c(S(=O)(=O)c2cccnc2)s1)C(=O)OC(C)(C)C",
        "output": "65"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Nc1cc2c(cn1)C(C)Oc1cc(Cl)ccc1-2.CC(C)C[C@@H](CO)NC(=O)OC(C)(C)C>>CC(=O)Nc1cc2c(cn1)C(C)Oc1cc(OC[C@H](CC(C)C)NC(=O)OC(C)(C)C)ccc1-2",
        "output": "57"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCN(CC)CC.CN(C)C=O.Cl.Clc1cc(Cl)nc(Cl)n1.NCCCBr>>Clc1cc(NCCCBr)nc(Cl)n1",
        "output": "166"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN1CCN(c2ccc([N+](=O)[O-])c(Cl)c2)CC1.CO.[Ni]>>CCN1CCN(c2ccc(N)c(Cl)c2)CC1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.COc1cc(Cl)cc(CCl)c1.[C-]#N.[Na+]>>COc1cc(Cl)cc(CC#N)c1",
        "output": "38"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC(N)CCC.CCN=C=NCCCN(C)C.CCOc1ccc(C(=O)O)cc1.Cl.ClCCl.On1nnc2ccccc21>>CCCC(CCC)NC(=O)c1ccc(OCC)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrBr.CCOCC.CCOc1cccc(C(F)(F)F)c1.O>>CCOc1ccc(Br)c(C(F)(F)F)c1",
        "output": "98"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(c1ccc([N+](=O)[O-])c(N2CCCCC2)c1)S(C)(=O)=O.[Pd]>>CN(c1ccc(N)c(N2CCCCC2)c1)S(C)(=O)=O",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccccc1OCCCCCCl.CS(C)=O.N#Cc1ccc(O)cc1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>COc1ccccc1OCCCCCOc1ccc(C#N)cc1",
        "output": "74"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOP(=O)(OCC)c1ccc(N)cc1.CN(C)c1ccncc1.CO.ClCCCl.ClCCl.ClCCl.O=C(O)c1ccc(Oc2ccccc2)cc1>>CCOP(=O)(OCC)c1ccc(NC(=O)c2ccc(Oc3ccccc3)cc2)cc1",
        "output": "50"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1Cc1cccc(OCc2nc(-c3ccc(Cl)cc3)cs2)c1>>NCc1cccc(OCc2nc(-c3ccc(Cl)cc3)cs2)c1",
        "output": "418"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCC(=O)Nc1nn(COCC[Si](C)(C)C)c2cc(-c3ccc(OCc4ccccc4)cc3)ccc12.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.[F-]>>CCCC(=O)Nc1n[nH]c2cc(-c3ccc(OCc4ccccc4)cc3)ccc12",
        "output": "813"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CCN(CCCO)Cc1cn(CCCCC(=O)OCC)nn1.CC(C)(C)N=[N+]=[N-].CC(C)(C)O.O.O=C1O[C@H]([C@@H](O)CO)C([O-])=C1O.O=C1O[C@H]([C@@H](O)CO)C([O-])=C1O.[Cu].[Na+]>>CCOC(=O)CCCCn1cc(CN(CCCO)Cc2cn(C(C)(C)C)nn2)nn1",
        "output": "963"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)CC1.CCOC(=O)N=NC(=O)OCC.N#Cc1ccc(O)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(C#N)cc2)CC1",
        "output": "846"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCNCC1.CC(C)Oc1cccc(OC(C)C)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.CCOC(C)=O.COC(C)(C)C.C[Si](C)(C)[N-][Si](C)(C)C.Cl[Pd+].NCCc1[c-]cccc1.Nc1ncc(Br)cc1[N+](=O)[O-].O.[Cl-].[Li+].[NH4+]>>CC(C)(C)OC(=O)N1CCN(c2cnc(N)c([N+](=O)[O-])c2)CC1",
        "output": "597"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CO.O=[N+]([O-])c1ccc(N2CCOCC2)cc1.[C].[Pd]>>Nc1ccc(N2CCOCC2)cc1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CN(C)C=O.CN(C)CCN(C)CCN(C)C.COc1ccccc1F.O.[Li]CCCC>>COc1cccc(C=O)c1F",
        "output": "239"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCO.Cc1ccc(N)cc1N(C)C.N#CCCCCBr>>Cc1ccc(NCCCCC#N)cc1N(C)C",
        "output": "273"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(O)Cn1cc([N+](=O)[O-])cn1.CCOC(C)=O.CN(C)C=O.C[Si](C)(C)Cl.c1c[nH]cn1>>CC(C)(Cn1cc([N+](=O)[O-])cn1)O[Si](C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=C(O)CCCCCCCCCCBr.OCc1ccccc1>>O=C(CCCCCCCCCCBr)OCc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC(CO)c1cccc(N(Cc2cccnc2)c2ccc(OC(F)F)c(OC(F)F)c2)c1.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)NC(CO)c1cccc(N(Cc2cccnc2)c2ccc(OC(F)F)c(OC(F)F)c2)c1",
        "output": "686"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COc1ccc(CCN(C)C(=O)C(F)(F)F)cc1OC.[Na+].[OH-]>>CNCCc1ccc(OC)c(OC)c1",
        "output": "703"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.Cl.Cl.NC1CCC2(CC1)CSC1=C(O2)c2ccccc2C(=O)C1=O.O=C(Cl)c1cccc(C(F)(F)F)c1>>O=C1C(=O)c2ccccc2C2=C1SCC1(CCC(NC(=O)c3cccc(C(F)(F)F)c3)CC1)O2",
        "output": "271"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCCCCBr.CN(C)C=O.O.O=C([O-])[O-].Oc1ccc(I)cc1.[K+].[K+]>>BrCCCCOc1ccc(I)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOc1nc2cccc(C(=O)OC(C)(C)OC(=O)OCCCCC(C)O[N+](=O)[O-])c2n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.CO>>CCOc1nc2cccc(C(=O)OC(C)(C)OC(=O)OCCCCC(C)O[N+](=O)[O-])c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1",
        "output": "815"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccccc1.CN(C)C=O.Cc1oc(-c2ccc(Br)cc2)nc1CCO.[H-].[Na+]>>Cc1oc(-c2ccc(Br)cc2)nc1CCOCc1ccccc1",
        "output": "464"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)Cl.O.O=C(Nc1ccc(F)cc1)NC1CCNCC1.c1ccncc1>>COC(=O)N1CCC(NC(=O)Nc2ccc(F)cc2)CC1",
        "output": "219"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)c1cc2c3c(Cl)cc(Cl)cc3n(C)c2s1.[K+].[OH-]>>Cn1c2cc(Cl)cc(Cl)c2c2cc(C(=O)O)sc21",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COCCCC1(N(C)C)CCC2(CC1)OCCO2.Cl.O>>COCCCC1(N(C)C)CCC(=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrC(Br)(Br)Br.CC#N.Cn1cc(CCO)c2ccccc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cn1cc(CCBr)c2ccccc21",
        "output": "378"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Nc1cc2nc(C)c(-c3cc(NC(=O)OC(C)(C)C)c(F)cc3F)cc2cn1.ClCCl.O=C(O)C(F)(F)F>>CC(=O)Nc1cc2nc(C)c(-c3cc(N)c(F)cc3F)cc2cn1",
        "output": "782"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc([N+](=O)[O-])ccc1N.O=C1OC(=O)c2ccccc21>>Cc1cc([N+](=O)[O-])ccc1N1C(=O)c2ccccc2C1=O",
        "output": "475"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCC.COc1cccc(C(O)CCc2ccccc2)c1.O.O=S(=O)(O)O.O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].[K+].[K+]>>COc1cccc(C(=O)CCc2ccccc2)c1",
        "output": "32"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)C=Cc2cccc(CN3CCC4(CC3)CNC4)c2O1.Cl.O=C(O)Cc1ccncc1>>CC1(C)C=Cc2cccc(CN3CCC4(CC3)CN(C(=O)Cc3ccncc3)C4)c2O1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN.CN(C)C=O.COc1cc(C(=O)O)ccc1Oc1ccc2c(c1)CCN(C(=O)OC(C)(C)C)CC2.O=C(n1ccnc1)n1ccnc1>>CNC(=O)c1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)CC3)c(OC)c1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C/C=C/c1nc2cc(C(F)(F)F)ccc2c(C)c1C(=O)OCC.CCO.O.[Na+].[OH-]>>C/C=C/c1nc2cc(C(F)(F)F)ccc2c(C)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCNCC1.CCOC(=O)C1CCN(c2cc(Cl)ccc2C=O)CC1.ClCCCl.O.[Na+]>>CCOC(=O)C1CCN(c2cc(Cl)ccc2CN2CCN(C(=O)OC(C)(C)C)CC2)CC1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CSC.N#Cc1ccc(CC(=O)O)cc1F>>N#Cc1ccc(CCO)cc1F",
        "output": "231"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.CCOC(C)=O.Cc1ccc2c(c1)C(C)(C)CCC2(C)C.Cl.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C",
        "output": "31"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1cc2c(C(F)(F)F)c(C#N)ccc2n1C(C)C(=O)O.Cl.F[P-](F)(F)(F)(F)F.N=C(NO)c1ccc(F)cc1>>Cc1cc2c(C(F)(F)F)c(C#N)ccc2n1C(C)c1nc(-c2ccc(F)cc2)no1",
        "output": "895"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCCCCCCOC1CCCCO1.CN(C)C=O.COC(=O)c1cccc(-c2cccc(O)c2)n1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cccc(-c2cccc(OCCCCCCOC3CCCCO3)c2)n1",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC=O.CO.ClCCl.N#Cc1ccc2c(c1)CNCC2.O.[BH3-]C#N.[Na+]>>CCN1CCc2ccc(C#N)cc2C1",
        "output": "858"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C1NC(=O)c2c1c(-c1ccccc1)cc1c2c2cc(O)ccc2n1CCCBr.c1c[nH]cn1>>O=C1NC(=O)c2c1c(-c1ccccc1)cc1c2c2cc(O)ccc2n1CCCn1ccnc1",
        "output": "495"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCc1nn(CCOCOCCOC)c(CC)c1Oc1cc(C#N)cc(C#N)c1.Cl.NO.O.O=C([O-])[O-].[Na+].[Na+]>>CCc1nn(CCOCOCCOC)c(CC)c1Oc1cc(C#N)cc(C(N)=NO)c1",
        "output": "400"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCC.Cc1cn([C@@H](C)CO[Si](C)(C)C(C)(C)C)cn1.Cl.ClCCl>>Cc1cn([C@@H](C)CO)cn1",
        "output": "708"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CI.C[C@@H](C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)[C@@H](O)c1ccc(Cl)c(Cl)c1.[H-].[Na+]>>CO[C@@H](c1ccc(Cl)c(Cl)c1)[C@@H](C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O",
        "output": "140"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccccc1C(CC(=O)c1ccncc1)c1ccc(N(C)C)cc1.Cl.NO.O=C([O-])O.[Na+]>>Cc1ccccc1C(C/C(=N\\O)c1ccncc1)c1ccc(N(C)C)cc1",
        "output": "212"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)c1ccc(C(=O)O)cc1.NN.Nc1ccccc1C(=O)NN=Cc1c(O)ccc2ccccc12.O=C(O)c1ccccc1>>CC(C)(C)c1ccc(C(=O)NN)cc1",
        "output": "55"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.Nc1nn2cc3c(nc2c1C(=O)Nc1cnccc1-c1ccccc1)CCNC3.O=C1COC1>>Nc1nn2cc3c(nc2c1C(=O)Nc1cnccc1-c1ccccc1)CCN(C1COC1)C3",
        "output": "983"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.CN(C)c1ccncc1.Cc1c(-c2ccn(C[C@H](C)NC(=O)c3csc(C(C)O)n3)n2)ccc(C#N)c1Cl.c1ccncc1>>CC(=O)OC(C)c1nc(C(=O)N[C@@H](C)Cn2ccc(-c3ccc(C#N)c(Cl)c3C)n2)cs1",
        "output": "254"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.ClCCl.N#CCc1c[nH]c2ccccc12>>CC(C)(C)OC(=O)n1cc(CC#N)c2ccccc21",
        "output": "748"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2ccc(C#CC(C)(O)c3ccc(F)cc3)cc2c1-c1ccc(Cl)cc1.CO.O.[Na+].[OH-]>>Cc1cc2ccc(C#CC(C)(O)c3ccc(F)cc3)cc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1ccc(CO)cn1.Cc1ccccc1.O=S(Cl)Cl.[Na+].[OH-]>>COc1ccc(CCl)cn1",
        "output": "477"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.COc1cc2ncnc(Cl)c2cc1OC(C)=O.Nc1ccc(Br)cc1F>>COc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1OC(C)=O",
        "output": "352"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCO.CS(=O)(=O)Cc1cccc(Nc2ncnc(-c3ccc(F)cc3F)n2)c1>>CCCOc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=O)c2)n1",
        "output": "485"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.CCOP(=O)(CC(=O)O)OCC.CN(C)C=O.O=C(Cl)C(=O)Cl.c1ccc2c(c1)CCN2.c1ccccc1>>CCOP(=O)(CC(=O)N1CCc2ccccc21)OCC",
        "output": "315"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.NN.O.O=C1c2ccccc2C(=O)N1Cc1cc(C2=CCC(C(F)(F)F)CC2)c(F)cn1>>NCc1cc(C2=CCC(C(F)(F)F)CC2)c(F)cn1",
        "output": "242"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1c(C)nc2ccc([N+](=O)[O-])cc2c1-c1ccccc1.O=C[O-].[NH4+].[Pd]>>COC(=O)c1c(C)nc2ccc(N)cc2c1-c1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C)(Cc1ccccc1)Sc1ccc(OC)cc1.CO.[Na+].[OH-]>>COc1ccc(SC(C)(Cc2ccccc2)C(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COc1cc(N2CCC(N3CCCCC3)CC2)c(Cl)cc1[N+](=O)[O-].[Pt]>>COc1cc(N2CCC(N3CCCCC3)CC2)c(Cl)cc1N",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ccc(Cl)nn1.CNCCC(C)C>>CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ccc(N(C)CCC(C)C)nn1",
        "output": "406"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C)CC(=O)c2c(nc(Cc3ccc(N)cc3)c3[nH]c4ccccc4c23)C1.CCC(=O)Cl>>CCC(=O)Nc1ccc(Cc2nc3c(c4c2[nH]c2ccccc24)C(=O)CC(C)(C)C3)cc1",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C=CCOc1cccc(C=O)c1OCC=C.C[Mg]Br.ClCCl>>C=CCOc1cccc(C(C)O)c1OCC=C",
        "output": "787"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.NC(=O)c1cnc(N)c([N+](=O)[O-])c1.[H][H].[Pd]>>NC(=O)c1cnc(N)c(N)c1",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCc1cc(O)c(CC=C)c(C=O)c1O.CCO.Cl.NO.O>>C=CCc1cc(O)c(CC=C)c(C=NO)c1O",
        "output": "30"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=Cc1ccc(F)cc1.Oc1ccc(Cl)c(F)c1>>O=Cc1ccc(Oc2ccc(Cl)c(F)c2)cc1",
        "output": "564"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "NCCN1CCCC1.O=C(O)c1ccc(-c2cnc3c(c2)N(Cc2cc(F)ccc2F)C(=O)CN3)cc1>>O=C(NCCN1CCCC1)c1ccc(-c2cnc3c(c2)N(Cc2cc(F)ccc2F)C(=O)CN3)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(=O)c1c(C)cc(OC2CCCC2)cc1C.CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.[Br-].[Br-].[Br-]>>Cc1cc(OC2CCCC2)cc(C)c1C(=O)CBr",
        "output": "360"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CC(=O)O.CC(C)COC(=O)Cl.CN1CCOCC1.Cl.ClCCl.Fc1ccc(OCC2CCNCC2)cc1.O>>C=CC(=O)N1CCC(COc2ccc(F)cc2)CC1",
        "output": "517"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(=O)CCNC.CN(C)C=O.Cc1c(C(Nc2ccc(C(=O)O)cc2)C2CCCCC2)sc2cnccc12.Cl.O.On1nnc2ccccc21.[Cl-].[NH4+]>>CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2sc3cnccc3c2C)C2CCCCC2)cc1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@H](C(=O)O)CC1.CCN(C(C)C)C(C)C.Cl.ClCCl.F[P-](F)(F)(F)(F)F.NC(CCCc1ccccc1)CCCc1ccccc1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CC(C)(C)OC(=O)N[C@H]1CC[C@@H](C(=O)NC(CCCc2ccccc2)CCCc2ccccc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.Cc1cccc(-n2nnn(C)c2=O)c1CBr.O.O=C([O-])[O-].Oc1ccc(Br)c(C(F)(F)F)c1.[K+].[K+]>>Cc1cccc(-n2nnn(C)c2=O)c1COc1ccc(Br)c(C(F)(F)F)c1",
        "output": "127"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.Cc1c(Br)cccc1-n1cnc2ccc(F)cc2c1=O.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1c(B2OC(C)(C)C(C)(C)O2)cccc1-n1cnc2ccc(F)cc2c1=O",
        "output": "942"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1C(=O)C(F)(F)CN(C2CCCC2)c2nc(Nc3ccc(C(=O)O)cc3C(F)(F)F)ncc21.CN1CCC(N)CC1.F[P-](F)(F)(F)(F)F>>CN1CCC(NC(=O)c2ccc(Nc3ncc4c(n3)N(C3CCCC3)CC(F)(F)C(=O)N4C)c(C(F)(F)F)c2)CC1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.CN(C)C=O.COc1cc(CCl)cc(OC)c1Br.O.[H-].[Na+]>>COc1cc(COC(C)C)cc(OC)c1Br",
        "output": "208"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "N.O=C(O)CC1(NC(=O)c2ccc(C3CC3)c(Cc3ccc(F)cc3)n2)CN(C(=O)OCc2ccccc2)C1.O=C(n1ccnc1)n1ccnc1>>NC(=O)CC1(NC(=O)c2ccc(C3CC3)c(Cc3ccc(F)cc3)n2)CN(C(=O)OCc2ccccc2)C1",
        "output": "313"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.O=[N+]([O-])O.Oc1cc(F)ccc1F>>O=[N+]([O-])c1cc(F)c(O)cc1F",
        "output": "21"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1cccc(C2=C(CC(C)N3CCCCC3)C(=O)NCCC2)c1.ClCCl.[Na+].[OH-]>>CC(CC1=C(c2cccc(O)c2)CCCNC1=O)N1CCCCC1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CNc1nc2ccc(C)cc2cc1C=O.[BH4-].[Na+]>>CNc1nc2ccc(C)cc2cc1CO",
        "output": "476"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(-c2nc(N)sc2Cc2ccc([N+](=O)[O-])cc2)cc1.O=C(Cl)c1ccc(F)cc1>>COc1ccc(-c2nc(NC(=O)c3ccc(F)cc3)sc2Cc2ccc([N+](=O)[O-])cc2)cc1",
        "output": "673"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.CS(=O)(=O)c1ccc2c(ccn2-c2ccc(OC3CCN(C(=O)CCl)CC3)cn2)c1>>CS(=O)(=O)c1ccc2c(ccn2-c2ccc(OC3CCN(C(=O)CN4CCOCC4)CC3)cn2)c1",
        "output": "340"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNC.Cl.F[P-](F)(F)(F)(F)F.Nc1ncc(Br)nc1C(=O)O>>CN(C)C(=O)c1nc(Br)cnc1N",
        "output": "729"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CS(=O)(=O)Nc1cc(Br)c2cc[nH]c2c1.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2cc(NS(C)(=O)=O)cc3[nH]ccc23)OC1(C)C",
        "output": "934"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Nc1ccc2c(c1)sc1nc(-c3ccccc3)cn12.COCCO.Cl.O>>Nc1ccc2c(c1)sc1nc(-c3ccccc3)cn12",
        "output": "66"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC/C=C\\CCO.CCOCC.CN(C)c1ccccn1.Cl.ClCCl.O=C1CCC(=O)O1.c1ccncc1>>CCC=CCCOC(=O)CCC(=O)O",
        "output": "139"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CN(C2COC2)CCN1.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c(OC(F)F)c1.[K+].[K+]>>O=[N+]([O-])c1ccc(N2CCN(C3COC3)CC2)c(OC(F)F)c1",
        "output": "26"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)(c2ccccc2)CC1.CCN(C(C)C)C(C)C.ClCCl.NCc1ccccc1.O=S(Cl)Cl>>CC(C)(C)OC(=O)N1CCC(C(=O)NCc2ccccc2)(c2ccccc2)CC1",
        "output": "599"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.O.O=Cc1ccc(O)c2ccccc12.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>O=Cc1ccc(OS(=O)(=O)C(F)(F)F)c2ccccc12",
        "output": "731"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc2c(-c3ccc(F)cc3)cc(=O)oc2c1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>O=c1cc(-c2ccc(F)cc2)c2ccc(CBr)cc2o1",
        "output": "29"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COc1ccc(C(C)(C)C)cc1C#N.Cl.NO.O.O=C([O-])[O-].[Na+].[Na+]>>COc1ccc(C(C)(C)C)cc1C(N)=NO",
        "output": "400"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.O.[N-]=[N+]=NC[C@H]1C=Cc2cc(F)cc(-c3c(Cl)cccc3Cl)c2O1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NC[C@H]1C=Cc2cc(F)cc(-c3c(Cl)cccc3Cl)c2O1",
        "output": "89"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCCC(Oc1c(C)cc(/C=C/C(=O)OCC)cc1C)c1cccc(-c2ccc(C(F)(F)F)cc2)n1.CO.Cl.[Na+].[OH-]>>CCCCC(Oc1c(C)cc(/C=C/C(=O)O)cc1C)c1cccc(-c2ccc(C(F)(F)F)cc2)n1",
        "output": "122"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc2c(c1)N(CCN1CCC(NC(=O)OC(C)(C)C)CC1)C(=O)CO2.N#Cc1ccc2ccc(=O)n(CCN3CCC(N)CC3)c2c1>>Cc1ccc2c(c1)N(CCN1CCC(N)CC1)C(=O)CO2",
        "output": "538"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)NC(C)C.CCOC(=O)CCCN.Cc1cc(S(=O)(=O)Cl)ccc1NC(=O)c1cc(Cl)ncn1>>CCOC(=O)CCCNS(=O)(=O)c1ccc(NC(=O)c2cc(Cl)ncn2)c(C)c1",
        "output": "43"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.Cl.ClCCl.Cn1cc(Nc2nccc(NC3CCC4(CC3)CCN(C(=O)OC(C)(C)C)C4)n2)cn1.O.O=C([O-])[O-].[Na+].[Na+]>>Cn1cc(Nc2nccc(NC3CCC4(CCNC4)CC3)n2)cn1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CO.O=C(O)Cc1ccccc1[N+](=O)[O-].O=S(=O)(Cl)Cl>>COC(=O)Cc1ccccc1[N+](=O)[O-]",
        "output": "195"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCc1cnc(Cl)nc1.Cc1cc(OCCCC2CCNCC2)cc(C)c1C(=O)O.Cl>>CCc1cnc(N2CCC(CCCOc3cc(C)c(C(=O)O)c(C)c3)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O.O=S(=O)(c1ccccc1)n1cc(-c2cccnc2)c2ccc(F)cc21.[Na+].[OH-]>>Fc1ccc2c(-c3cccnc3)c[nH]c2c1",
        "output": "771"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.CN1CCN(C2CCNCC2)CC1.COc1cc(F)ccc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCCCc1cc2c(cc1/C=C/c1ccc(C(=O)OCC)cc1)C(C)(C)CCC2(C)C.CCO.Cl.O.[K+].[OH-]>>CCCCCCc1cc2c(cc1/C=C/c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C",
        "output": "5"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.COC(=O)[C@@H](N)CO.Cc1cc(C(=O)O)ccc1[N+](=O)[O-].Cl.Cl.ClCCl>>COC(=O)[C@H](CO)NC(=O)c1ccc([N+](=O)[O-])c(C)c1",
        "output": "652"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COc1cc(OC)c2c(c1)O/C(=C\\c1ccccc1)C2=O.ClCCl.O>>O=C1/C(=C/c2ccccc2)Oc2cc(O)cc(O)c21",
        "output": "20"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)NCC(=O)c1cc(Cl)c(N)c(C#N)c1.[BH4-].[Na+]>>CC(C)(C)NCC(O)c1cc(Cl)c(N)c(C#N)c1",
        "output": "24"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "N#Cc1cc(CO)ccc1Oc1ccc(F)c(F)c1.O=c1nc(Cl)cc2n1CCN2C1CC1>>N#Cc1cc(COc2cc3n(c(=O)n2)CCN3C2CC2)ccc1Oc1ccc(F)c(F)c1",
        "output": "653"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.CCOC(=O)CC(Cc1cccc(OC)c1)C(C)C.[Na+].[OH-]>>COc1cccc(CC(CC(=O)O)C(C)C)c1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CCOC(=O)c1cc[nH]c1C.Cc1ccccc1.O.O=S(=O)(Cl)c1ccccc1.[Br-].[Na+].[OH-]>>CCOC(=O)c1ccn(S(=O)(=O)c2ccccc2)c1C",
        "output": "648"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCc1ccccc1C(=O)O.Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1.O=S(Cl)Cl>>CCc1ccccc1C(=O)Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1cc(-c2ccc(OCc3ccccc3)cc2)n(-c2ccc(Cl)cc2Cl)n1.CSC.ClCCl>>CCOC(=O)c1cc(-c2ccc(O)cc2)n(-c2ccc(Cl)cc2Cl)n1",
        "output": "23"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccc(F)c(Br)c1.O=C([O-])[O-].O=[Cu-].[Mg+2].[Na+].[O-]c1ccccc1.c1ccc2cnccc2c1>>Cc1ccc(F)c(Oc2ccccc2)c1",
        "output": "238"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrBr.CC(=O)Nc1cccc(F)c1C.CC(=O)O>>CC(=O)Nc1ccc(Br)c(F)c1C",
        "output": "98"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(C(=O)Cl)cc1.Cc1nc(N)sc1C(=O)NCc1ccccc1>>COc1ccc(C(=O)Nc2nc(C)c(C(=O)NCc3ccccc3)s2)cc1",
        "output": "673"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc2c(-c3ccc(N(C)C(=O)OC(C)(C)C)cc3)ccnc2n1S(=O)(=O)c1ccccc1.ClCCl.O=C(O)C(F)(F)F>>CNc1ccc(-c2ccnc3c2cc(C)n3S(=O)(=O)c2ccccc2)cc1",
        "output": "830"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1cc(C=O)cc2c1OC(C)C(=O)N2.ClCCl>>CC1Oc2c(O)cc(C=O)cc2NC1=O",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C.CS(=O)(=O)Cl.ClCCl>>COC(=O)[C@H](Cc1ccc(OS(C)(=O)=O)cc1)NC(=O)OC(C)(C)C",
        "output": "149"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cl.NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O.O=C(O)C(F)(F)c1ccc(F)cc1OCC(F)(F)F.O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+].c1ccncc1>>O=C1CCC(N2Cc3cc(CNC(=O)C(F)(F)c4ccc(F)cc4OCC(F)(F)F)ccc3C2=O)C(=O)N1",
        "output": "599"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C[C@H](CO)[C@H]1CC#C[Si](C)(C)C)O[Si](C)(C)C(C)(C)C.CO.C[O-].[Cl-].[NH4+].[Na+]>>C#CC[C@H]1[C@@H](/C=C/[C@H](CCCCC)O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1CO",
        "output": "337"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl.O=C(O)CN1CCC(c2ccccc2)(c2ccccc2)C1=O.c1ccc(C2(c3ccccc3)CCNCC2)cc1>>O=C(CN1CCC(c2ccccc2)(c2ccccc2)C1=O)N1CCC(c2ccccc2)(c2ccccc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cc1c[nH]c2cc(-c3ccc(OCC)cc3)nn2c1=O.CCOc1ccc(-c2cc(N)[nH]n2)cc1>>CCOc1ccc(-c2cc3[nH]cc(CC(=O)O)c(=O)n3n2)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1=COCCC1.Cc1ccc(S(=O)(=O)[O-])cc1.Cc1cccc(Br)c1O.ClCCl.c1cc[nH+]cc1>>Cc1cccc(Br)c1OC1CCCCO1",
        "output": "319"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C1CCNCC1.COc1ccc2nc(NC(=O)C(CC3CCCC3)c3ccc(S(=O)(=O)Cl)cc3)sc2n1.ClCCl>>CCOC(=O)C1CCN(S(=O)(=O)c2ccc(C(CC3CCCC3)C(=O)Nc3nc4ccc(OC)nc4s3)cc2)CC1",
        "output": "99"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)c1ccc(CNCCc2cccc(Cl)c2F)cc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O.O=C(O)c1cccc2cc[nH]c12>>CC(C)(C)c1ccc(CN(CCc2cccc(Cl)c2F)C(=O)c2cccc3cc[nH]c23)cc1",
        "output": "893"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCOCC.CC[SiH](CC)CC.COc1ccc(C(=O)c2ccc(C)cc2)c(C)c1.ClC(Cl)Cl.FB(F)F.O=C([O-])O.[Na+]>>COc1ccc(Cc2ccc(C)cc2)c(C)c1",
        "output": "181"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.O.O=S(=O)(CCn1ccnn1)Cc1ccc(O)cc1.O=S(c1ccc(C=Cc2nc(CCl)co2)cc1)C(F)(F)F.[H-].[Na+]>>O=S(c1ccc(/C=C/c2nc(COc3ccc(CS(=O)(=O)CCn4ccnn4)cc3)co2)cc1)C(F)(F)F",
        "output": "760"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)c1ccncc1.Cc1cccc(C(=O)O)c1.Cl.ClCCCl.NC(=O)n1c(-c2cccc(N)c2)cc2ccccc21>>Cc1cccc(C(=O)Nc2cccc(-c3cc4ccccc4n3C(N)=O)c2)c1",
        "output": "50"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NC1CCC(c2cnc(N)c(-c3ccc(C(=O)O)c(F)c3)n2)CC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CS(C)=O.F[P-](F)(F)(F)(F)F.N[C@H](CO)c1cccc(Cl)c1>>CC(C)(C)OC(=O)NC1CCC(c2cnc(N)c(-c3ccc(C(=O)N[C@H](CO)c4cccc(Cl)c4)c(F)c3)n2)CC1",
        "output": "753"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C(CCN1CCCC1)CC1CCNCC1.CCO.O=C1Nc2ccccc2N(C(=O)Cl)c2ncccc21>>O=C1Nc2ccccc2N(C(=O)N2CCC(CCCCN3CCCC3)CC2)c2ncccc21",
        "output": "258"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1Oc2c(cc(C=O)cc2C2CC2)NC1=O.CNC(=O)c1ccc(N2CCNCC2)cc1>>CNC(=O)c1ccc(N2CCN(Cc3cc4c(c(C5CC5)c3)OC(C)C(=O)N4)CC2)cc1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN.COc1cc2c(cc1OC)CN(C(=O)N1CCCC(CCN3C(=O)c4ccccc4C3=O)C1)CC2>>COc1cc2c(cc1OC)CN(C(=O)N1CCCC(CCN)C1)CC2",
        "output": "242"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1ccccn1.C#CCCc1nc2cc(F)cc(F)c2o1>>Fc1cc(F)c2oc(CCC#Cc3ccccn3)nc2c1",
        "output": "777"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C=CCBr.CN1CCCN(C)C1=O.O=C(N[C@@H](CO)c1ccccc1)C(F)(F)F.[Li]CCCC>>C=CCOC[C@H](NC(=O)C(F)(F)F)c1ccccc1",
        "output": "120"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.CCN(CC)CC.CN(C)C=O.O.O=C(CCl)Nc1cc(C(=O)Nc2ccc(-c3ccccc3)cc2)ccc1C(F)(F)F.[I-].[K+]>>O=C(CN1CCOCC1)Nc1cc(C(=O)Nc2ccc(-c3ccccc3)cc2)ccc1C(F)(F)F",
        "output": "340"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CN1CCN(C(=O)c2ccc([N+](=O)[O-])cc2)CC1.[H][H].[Ni]>>CN1CCN(C(=O)c2ccc(N)cc2)CC1",
        "output": "28"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCC(=O)Cl.Nc1c(-n2cncn2)cnn1-c1c(Cl)cc(C(F)(F)F)cc1Cl.O.c1ccncc1>>CCC(=O)Nc1c(-n2cncn2)cnn1-c1c(Cl)cc(C(F)(F)F)cc1Cl",
        "output": "527"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(c1ccc(Cl)cc1)c1nccs1.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>O=C(c1ccc(Cl)c([N+](=O)[O-])c1)c1nccs1",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(N)c1nc2ccc(F)cc2n1-c1cccc(F)c1.CCCCO.CCN(C(C)C)C(C)C.N#Cc1c(N)ncnc1Cl>>CC(Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2n1-c1cccc(F)c1",
        "output": "110"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COC(=O)CC1c2cccc(F)c2N=C(N2CCN(c3ccc(F)c(F)c3)CC2)N1c1cc(C(F)(F)F)ccc1OC.Cl.[Na+].[OH-]>>COc1ccc(C(F)(F)F)cc1N1C(N2CCN(c3ccc(F)c(F)c3)CC2)=Nc2c(F)cccc2C1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CO.O.O=c1[nH]cnc2cc(F)ccc12.OCC1(c2ccccc2)CCNCC1.[K+].[OH-]>>O=c1[nH]cnc2cc(OCC3(c4ccccc4)CCNCC3)ccc12",
        "output": "636"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCC1(CC)Cc2c(cc(C(C)C)c(OC(C)=O)c2C(C)C)O1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCC1(CC)Cc2c(cc(C(C)C)c(O)c2C(C)C)O1",
        "output": "22"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.Clc1cc(Cl)cc(Br)c1.Clc1ccccc1Cl.O=C([O-])[O-].[Cu].[K+].[K+].c1ccc2[nH]ccc2c1>>Clc1cc(Cl)cc(-n2ccc3ccccc32)c1",
        "output": "349"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CNCC1(c2ccc(OC3CCN(C(C)C)CC3)cc2)CCOCC1.ClCCl.O>>CC(=O)N(C)CC1(c2ccc(OC3CCN(C(C)C)CC3)cc2)CCOCC1",
        "output": "369"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1cccc(C(=O)O)c1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NC1CCCC1.O>>CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1cccc(C(=O)NC2CCCC2)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1CCC(O)CC1c1cccc(OCc2ccc3c(ccc(=O)n3C)c2)c1.CI>>COC1CCC(C)C(c2cccc(OCc3ccc4c(ccc(=O)n4C)c3)c2)C1",
        "output": "140"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CC1CC1.CC(C)NC(C)C.COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1I.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O.[Cu]I>>COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1C#CC1CC1",
        "output": "664"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrBr.CC(=O)O.Nc1ccc(Cl)cn1.O=S([O-])([O-])=S.[Na+].[Na+]>>Nc1ncc(Cl)cc1Br",
        "output": "292"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCN1.CO.O=Cc1cc(Br)c2nc(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)[nH]c2c1.[BH3-]C#N.[Na+]>>O=c1[nH]ccc(NC[C@@H](O)c2cccc(Cl)c2)c1-c1nc2c(Br)cc(CN3CCOCC3)cc2[nH]1",
        "output": "567"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=C(CCCCCl)c1cccc(C(F)(F)F)c1.O=C(Nc1cccc(C2CCNCC2)c1)C1CC1>>O=C(CCCCN1CCC(c2cccc(NC(=O)C3CC3)c2)CC1)c1cccc(C(F)(F)F)c1",
        "output": "138"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "B.C1CCOC1.CC(C)(C)OC(=O)N1CCN(Cc2cccc(-c3cccc(C#N)c3)c2)CC1>>CC(C)(C)OC(=O)N1CCN(Cc2cccc(-c3cccc(CN)c3)c2)CC1",
        "output": "175"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.COCCO.Cl.O.O=C(c1cccc(C(=O)c2ccc(F)c([N+](=O)[O-])c2)c1)c1ccc(F)c([N+](=O)[O-])c1.[Cl-].[Fe].[Na+]>>Nc1cc(C(=O)c2cccc(C(=O)c3ccc(F)c(N)c3)c2)ccc1F",
        "output": "204"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCOS(C)(=O)=O.COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)[C@H](Cc1ccc(OCCNC(=O)OC(C)(C)C)cc1)NC(=O)OCc1ccccc1",
        "output": "702"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC[BH-](CC)CC.COC(=O)c1ccc(Cl)c(S(C)(=O)=O)c1.O.[Li+]>>CS(=O)(=O)c1cc(CO)ccc1Cl",
        "output": "444"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CN2CCN1CC2.CC1C=CC(N)C2CNCC12.CCn1cc(C(=O)O)c(=O)c2ccc(F)c(Cl)c21.CS(C)=O>>CCn1cc(C(=O)O)c(=O)c2ccc(N3CC4C(C)C=CC(N)C4C3)c(Cl)c21",
        "output": "676"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)[C@H](CCc1ccccc1)OCC(=O)N1CCOCC1.O.O.O.[Li+].[OH-]>>O=C(O)[C@H](CCc1ccccc1)OCC(=O)N1CCOCC1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1sc2nc(-c3cccnc3)nc(Cl)c2c1Cl.NCc1ccccc1>>Cc1sc2nc(-c3cccnc3)nc(NCc3ccccc3)c2c1Cl",
        "output": "906"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cc(OC)c(S(=O)(=O)Cl)cc1C(=O)O.Cl.N>>COc1cc(OC)c(S(N)(=O)=O)cc1C(=O)O",
        "output": "245"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C=CCOP(=O)(OCC=C)OCc1c(C)cccc1CO[Si](C)(C)C(C)(C)C.CCCCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.O.[F-]>>C=CCOP(=O)(OCC=C)OCc1c(C)cccc1CO",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)COc1ccc(CN2C(=O)COC3(CCN(C(=O)OCc4ccccc4)CC3)C2Cc2ccc(F)cc2)cc1.CCO.[Pd]>>CC(C)COc1ccc(CN2C(=O)COC3(CCNCC3)C2Cc2ccc(F)cc2)cc1",
        "output": "428"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COCCN.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2c(c1)nc(Nc1nc3ccc(OC(F)(F)F)cc3s1)n2CCF>>COCCNC(=O)c1ccc2c(c1)nc(Nc1nc3ccc(OC(F)(F)F)cc3s1)n2CCF",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CN(c1ccc([C@H]2CNCCO2)cc1)c1ccccn1.Cn1c(Cl)nc(-c2ccncc2)cc1=O>>CN(c1ccc([C@H]2CN(c3nc(-c4ccncc4)cc(=O)n3C)CCO2)cc1)c1ccccn1",
        "output": "36"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.Fc1cccc2ncnc(Cl)c12.Nc1ccc2c(cnn2Cc2cccc(F)c2)c1>>Fc1cccc(Cn2ncc3cc(Nc4ncnc5cccc(F)c45)ccc32)c1",
        "output": "352"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)COc1ccc(C(=O)c2ccc(OCC(C)C)c(CC(=O)O)c2)c(OCC(C)C)c1.CO.Cl.ClC(Cl)Cl.O.[BH4-].[Cl-].[Li+].[Na+]>>CC(C)COc1ccc(C(O)c2ccc(OCC(C)C)c(CC(=O)O)c2)c(OCC(C)C)c1",
        "output": "157"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCNc1ncc2c(n1)N1CCC[C@H]1CN(c1cccc(OC3CCNCC3)c1)C2=O.ClCCCl.O=C([O-])O.[Na+].[Na+]>>CCNc1ncc2c(n1)N1CCC[C@H]1CN(c1cccc(OC3CCN(C)CC3)c1)C2=O",
        "output": "217"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)[C@H](NC(=O)c1cc2ccccc2n1CC(=O)OC(C)(C)C)C(=O)NC(CC(=O)OC(C)(C)C)C(O)COc1c(F)c(F)cc(F)c1F.ClCCl>>CC(C)[C@H](NC(=O)c1cc2ccccc2n1CC(=O)OC(C)(C)C)C(=O)NC(CC(=O)OC(C)(C)C)C(=O)COc1c(F)c(F)cc(F)c1F",
        "output": "87"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCc1coc(-c2cccs2)n1.Oc1ccc(CCCCn2ccnc2)cc1>>c1csc(-c2nc(COc3ccc(CCCCn4ccnc4)cc3)co2)c1",
        "output": "760"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1ccc2c(c1)CCC(Oc1ccnc(C(=O)OC)c1)C2.O.[K+].[OH-]>>COC(=O)c1ccc2c(c1)CCC(Oc1ccnc(C(=O)O)c1)C2",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)n1nc(Br)c2ccc([N+](=O)[O-])cc2c1=O.CCO.Cl.O.[Fe]>>CC(C)n1nc(Br)c2ccc(N)cc2c1=O",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)[C@](C)(N)CO.O=C(O)c1cc(OCC2CC2)c(Cl)cn1>>CC(C)[C@@](C)(CO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1",
        "output": "137"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cl.O=C(O)c1c[nH]c2c(Cl)cccc12>>COC(=O)c1c[nH]c2c(Cl)cccc12",
        "output": "521"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CI.CS(C)=O.Oc1cccnc1Br.[OH-]>>COc1cccnc1Br",
        "output": "661"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Nc1ccc(SCCCCOc2ccc3c(c2)C(C2CCCCC2)(C2CCCCC2)OC(=O)N3)cc1.OO>>CC(=O)Nc1ccc(S(=O)CCCCOc2ccc3c(c2)C(C2CCCCC2)(C2CCCCC2)OC(=O)N3)cc1",
        "output": "199"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCOc1n[nH]c2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12.OC1CCNCC1>>OC1CCN(CCOc2n[nH]c3ncnc(Nc4ccc(OCc5ccccn5)c(Cl)c4)c23)CC1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCNC1CCN(Cc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)CC1.CO.Cl.ClCCl.ClCCl.O=C(NCC1CC1)Nc1ccc(C(=O)O)cc1>>CCN(C(=O)c1ccc(NC(=O)NCC2CC2)cc1)C1CCN(Cc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CS(=O)(=O)Nc1ccc(CC(=O)O)cc1.Cl.NCC1CN(Cc2cccc(F)c2)CCO1.On1nnc2ccccc21>>CS(=O)(=O)Nc1ccc(CC(=O)NCC2CN(Cc3cccc(F)c3)CCO2)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)c1ccncc1.ClCCl.Nc1ccc(F)cc1.O=C(Cl)C=Cc1ccccc1.c1ccncc1>>O=C(C=Cc1ccccc1)Nc1ccc(F)cc1",
        "output": "10"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CCN(CC)CC.Cc1nc(C(=O)N2CCOC3(CCNCC3)C2)cs1.O=C(O)C(F)(F)F.OCCc1ccc(CBr)cc1>>Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(CCO)cc4)CC3)C2)cs1",
        "output": "248"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Nc1ccc(Cl)cn1.O=S(=O)(O)O.O=[N+]([O-])O.[Na+].[OH-]>>Nc1ncc(Cl)cc1[N+](=O)[O-]",
        "output": "328"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.COC(=O)C1CCNCC1.CS(=O)(=O)OCCc1c(-c2ccccc2)[nH]c2ccccc12.O=C([O-])O.[Na+]>>COC(=O)C1CCN(CCc2c(-c3ccccc3)[nH]c3ccccc23)CC1",
        "output": "496"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1ccc(C2CCNCC2)cc1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl>>CC(C)(C)OC(=O)N1CCC(c2ccc(Br)cc2)CC1",
        "output": "694"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCC.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COc1cc(Nc2ncc(-c3cncc(C(=O)O)c3)c(-n3nc(C(F)(F)F)cc3C)n2)cc(OC)c1.ClCCl.F[B-](F)(F)F.NCCO.On1nnc2ccccc21>>COc1cc(Nc2ncc(-c3cncc(C(=O)NCCO)c3)c(-n3nc(C(F)(F)F)cc3C)n2)cc(OC)c1",
        "output": "674"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1cccc(-c2nc(Nc3ccncc3)nc(NC(C)C)n2)c1.ClCCl.O.O=C([O-])O.[Na+]>>CC(C)Nc1nc(Nc2ccncc2)nc(-c2cccc(O)c2)n1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O.[Na+].[OH-]>>O=C(O)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(C)=O.Cc1cc([N+](=O)[O-])cnc1Cl.O=C(OCc1ccccc1)N1CCC([C@H]2C[C@H]2CCO)CC1.[H-].[Na+]>>Cc1cc([N+](=O)[O-])cnc1OCC[C@@H]1C[C@@H]1C1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "433"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(c1ccc2[nH]c(C(=O)Nc3cc(F)cc(F)c3)cc2c1)C1CCNC1.CN1CCCC1=O.N#CCBr>>CC(c1ccc2[nH]c(C(=O)Nc3cc(F)cc(F)c3)cc2c1)C1CCN(CC#N)C1",
        "output": "880"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCCN.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1ccc(Nc2ncc3c(n2)-c2ccc(C(=O)O)cc2NC(=O)C3)cc1OC.F[B-](F)(F)F.O>>COc1ccc(Nc2ncc3c(n2)-c2ccc(C(=O)NCCNC(=O)OC(C)(C)C)cc2NC(=O)C3)cc1OC",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=O.CCO.COc1ccc2c(c1OC)CNCCc1cc(O)ccc1CC2.O=[Pt].[H][H]>>COc1ccc2c(c1OC)CN(C)CCc1cc(O)ccc1CC2",
        "output": "69"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.CC(=O)O.CCn1c(SC(C)c2noc(-c3cccc(Cl)c3)n2)nnc1-c1ccnc(OC)c1.O=C([O-])O.[Na+]>>CCn1c(SC(C)c2noc(-c3cccc(Cl)c3)n2)nnc1-c1ccnc(O)c1",
        "output": "408"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COc1c(C)c2c(c(C(=O)O)c1C/C=C(\\C)CCC(=O)O)C(=O)OC2.Cc1ccc(S(=O)(=O)O)cc1>>COC(=O)CC/C(C)=C/Cc1c(OC)c(C)c2c(c1C(=O)O)C(=O)OC2",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.Cn1c(=O)n(C(=O)N2CCCC2)c2cnc(-c3cccc(OCc4ccccc4)c3)nc21.[Pd]>>Cn1c(=O)n(C(=O)N2CCCC2)c2cnc(-c3cccc(O)c3)nc21",
        "output": "23"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCCC(=O)O.CN(C)c1ccncc1.ClCCl.Nc1cccc(O)c1>>CCCC(=O)Nc1cccc(O)c1",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cc1ccc(S(=O)(=O)[O-])cc1.F[P-](F)(F)(F)(F)F.N=C(NCCC[C@H](NC(=O)OCc1ccccc1)C(=O)O)N[N+](=O)[O-].NCC(=O)OCc1ccccc1.O>>N=C(NCCC[C@H](NC(=O)OCc1ccccc1)C(=O)NCC(=O)OCc1ccccc1)N[N+](=O)[O-]",
        "output": "132"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)c1ccc(OCC(=O)O)cc1OCC1CC1.CCN(CC)CC.CN1CC[NH+](C)C1Cl.CS(=O)(=O)Nc1ccc(CN)cc1F.Cl.[Cl-]>>CC(C)(C)c1ccc(OCC(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1OCC1CC1",
        "output": "599"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.O=C1CCC(C=Cc2cc(F)c(F)c(F)c2)CC1.[H][H].[Pd]>>O=C1CCC(CCc2cc(F)c(F)c(F)c2)CC1",
        "output": "362"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.O=C(O)c1ccc(Oc2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cn2)cc1.O=C1CCc2cc(CN3CCNCC3)ccc2N1.On1nnc2ccccc21>>O=C1CCc2cc(CN3CCN(C(=O)c4ccc(Oc5ccc(NC(=O)c6ccc(C(F)(F)F)cc6)cn5)cc4)CC3)ccc2N1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC[C@@H]1CC[C@H](C(=O)O)CC1.CN1CCCCC1.CNOC.COC(=O)Cl.Cl.ClCCl>>CON(C)C(=O)[C@@H]1CC[C@H](CNC(=O)OC(C)(C)C)CC1",
        "output": "54"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N(CC1CC1)C1CCNCC1.CS(=O)(=O)N1CCC([C@@H](CC=O)c2cc(F)cc(F)c2)CC1.ClCCl.[Na+]>>CC(C)(C)OC(=O)N(CC1CC1)C1CCN(CC[C@@H](c2cc(F)cc(F)c2)C2CCN(S(C)(=O)=O)CC2)CC1",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1cccnc1OC1CCN(c2ccc3ccccc3n2)CC1.CC(C)(C)[O-].Cc1ccccc1.N#CC1CCNCC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>N#CC1CCN(c2cccnc2OC2CCN(c3ccc4ccccc4n3)CC2)CC1",
        "output": "597"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)c1ccc(Br)nc1.COC(OC)N(C)C>>CN(C)/C=C/C(=O)c1ccc(Br)nc1",
        "output": "898"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CC(C)(C)c1ccccc1O.CO.Cl.ClCCl.O.O=C([O-])[O-].[Al+3].[Cl-].[Cl-].[Cl-].[K+].[K+]>>CC(=O)c1ccc(C(C)(C)C)c(O)c1",
        "output": "31"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C(N[C@H]1CN[C@H](C(=O)Nc2ccc(Oc3ccc(F)cc3)cc2)C1)OCc1ccccc1.O=C(O)Cn1cncn1>>O=C(N[C@@H]1C[C@@H](C(=O)Nc2ccc(Oc3ccc(F)cc3)cc2)N(C(=O)Cn2cncn2)C1)OCc1ccccc1",
        "output": "297"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)[C@@H]1CC[C@@H](C(C)O)N(C(=O)OCc2ccccc2)C1.ClCCl>>COC(=O)[C@@H]1CC[C@@H](C(C)=O)N(C(=O)OCc2ccccc2)C1",
        "output": "650"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)c1cc(C)nc(CC(C)C)c1.CO.Cl.NO.O.[Na+].[OH-]>>CC(=NO)c1cc(C)nc(CC(C)C)c1",
        "output": "212"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.C1CCOC1.CC1CN(C(=O)OC(C)(C)C)CC=C1c1cnc(CO[Si](C)(C)C(C)(C)C)c(Cl)c1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.[F-]>>CC1CN(C(=O)OC(C)(C)C)CC=C1c1cnc(CO)c(Cl)c1",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.C1COCCO1.CC(C)(C)OC(=O)N1CCCN(c2cncc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)CC1.Cl>>FC(F)(F)Cn1cc(-c2cc3c(cn2)cnn3-c2cncc(N3CCCNCC3)n2)cn1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br.CCOc1cnc(OC)cc1-c1cc(Cl)ccc1C#N.c1cc[nH+]cc1>>CCOc1c[nH]c(=O)cc1-c1cc(Cl)ccc1C#N",
        "output": "758"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COc1c([N+](=O)[O-])ccc2c1CCCC(N1CCN(CCO)CC1)C2.[Pd]>>COc1c(N)ccc2c1CCCC(N1CCN(CCO)CC1)C2",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C(Nc1ccc(C(F)(F)F)cc1Cl)C(=O)O.CCOCC.N#CC(O)c1cccc(Oc2cccc(F)c2)n1>>CC(C)C(Nc1ccc(C(F)(F)F)cc1Cl)C(=O)OC(C#N)c1cccc(Oc2cccc(F)c2)n1",
        "output": "17"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.C[C@@H](O[C@H]1CCN(C(=O)C2CCNCC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl>>CC(=O)N1CCC(C(=O)N2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc(N2CCNCC2)c(Cl)cc1Cl.Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)O.F[P-](F)(F)(F)(F)F>>COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)c(Cl)cc1Cl",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CC(=O)Cl.CCN(CC)CC.CN(C)C=O.CN[C@H](C)c1oc2ccccc2c1C.O>>C=CC(=O)N(C)[C@H](C)c1oc2ccccc2c1C",
        "output": "135"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)O)ncn3)CC1)C(=O)N2.F[B-](F)(F)F.Nc1ccccc1>>COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)Nc4ccccc4)ncn3)CC1)C(=O)N2",
        "output": "548"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.ClCCl.NC(=O)C1CCNCC1.O=C(Cl)C(=O)Cl.O=C(O)c1ccccc1-c1ccc(C(F)(F)F)cc1.O=C([O-])O.[Na+]>>NC(=O)C1CCN(C(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CO.COc1ccc(-c2ccc(-c3ccccc3)nc2-c2ccc(OCc3ccccc3)cc2)cc1.ClC(Cl)Cl.O=C[O-].[NH4+].[Pd]>>COc1ccc(-c2ccc(-c3ccccc3)nc2-c2ccc(O)cc2)cc1",
        "output": "23"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCC2=NCCCN2CC1.CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1F.CN(C)c1ccncc1.O=C(O)c1ccccc1F.O=C(n1ccnc1)n1ccnc1>>CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F",
        "output": "579"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.ClCC1CO1.Oc1cc(C(F)(F)F)ccc1I.[H-].[Na+]>>FC(F)(F)c1ccc(I)c(OCC2CO2)c1",
        "output": "15"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1cccc(CN)c1.ClCCl.O=S(=O)(Cl)c1ccc(Br)cc1.c1ccncc1>>COC(=O)c1cccc(CNS(=O)(=O)c2ccc(Br)cc2)c1",
        "output": "530"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCCOCCOc1ccc(-c2cc3c4c(c2)CCN4CCCC(C(=O)OC)=C3)cc1.CCO.Cl.[Na+].[OH-]>>CCCCOCCOc1ccc(-c2cc3c4c(c2)CCN4CCCC(C(=O)O)=C3)cc1",
        "output": "58"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CC(=O)Cl.ClCCl.O=C([O-])O.Oc1cccc(CCNC2CCCCC2)c1.[Na+]>>C=CC(=O)N(CCc1cccc(O)c1)C1CCCCC1",
        "output": "135"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1nc(-c2ccc(CN)c([N+](=O)[O-])c2)no1>>Cc1nc(-c2ccc(CNC(=O)OC(C)(C)C)c([N+](=O)[O-])c2)no1",
        "output": "686"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C(=O)O)C(c1ccccc1)c1ccc2c(ccn2-c2ccc(F)cc2)c1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1nccs1>>CC(C)(C(=O)Nc1nccs1)C(c1ccccc1)c1ccc2c(ccn2-c2ccc(F)cc2)c1",
        "output": "681"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1=CC2(CCN(C(=O)c3cnc4c(C(=O)O)cnn4c3NCc3ccccc3)CC2)c2ccccc21.CS(N)(=O)=O>>CC1=CC2(CCN(C(=O)c3cnc4c(C(=O)NS(C)(=O)=O)cnn4c3NCc3ccccc3)CC2)c2ccccc21",
        "output": "991"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNC1.CC#N.CCN(C(C)C)C(C)C.COc1cc(C)nc(Cl)c1C#N.O>>COc1cc(C)nc(N2CCCC2)c1C#N",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COc1ccc(-c2ccc3cc(O)ccc3c2)c(C)c1.O=C1CCC(=O)N1Cl>>COc1ccc(-c2ccc3c(Cl)c(O)ccc3c2)c(C)c1",
        "output": "121"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN.COc1ccc(-c2nn(Cc3ccccc3)c(=O)c(C(=O)O)c2-c2ccc(OC)cc2)cc1.Cl>>CCNC(=O)c1c(-c2ccc(OC)cc2)c(-c2ccc(OC)cc2)nn(Cc2ccccc2)c1=O",
        "output": "674"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(O)c1ccc(C(F)(F)F)cc1[N+](=O)[O-].[Pd]>>Nc1cc(C(F)(F)F)ccc1C(=O)O",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.COc1ccc(-c2cc(C(=O)O)c3ccccc3n2)cc1.ClCCl.Nc1cccc(F)n1>>COc1ccc(-c2cc(C(=O)Nc3cccc(F)n3)c3ccccc3n2)cc1",
        "output": "744"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CCCCBr.CO.NC1CC1>>C=CCCCNC1CC1",
        "output": "147"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.COC(=O)c1cc(-n2ccccc2=O)ccc1-n1cnc(CN)c1.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(Cl)s1>>COC(=O)c1cc(-n2ccccc2=O)ccc1-n1cnc(CNC(=O)c2ccc(Cl)s2)c1",
        "output": "736"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=Cc1ccc(C)cc1C.COc1ccc2ccccc2c1I>>COc1ccc2ccccc2c1/C=C/c1ccc(C)cc1C",
        "output": "725"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc2c(Cl)ncnc2cc1O.CS(=O)(=O)N1CCN(CCCO)CC1>>COc1cc2c(Cl)ncnc2cc1OCCCN1CCN(S(C)(=O)=O)CC1",
        "output": "478"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1O.Cc1ccc(S(=O)(=O)OCC2CCN(C(=O)OC(C)(C)C)CC2)cc1.O.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "438"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C([O-])O.OC1C2CCN(CC2)C1Cc1cccnc1.[Na+]>>CS(=O)(=O)OC1C2CCN(CC2)C1Cc1cccnc1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cn1c(-c2cncc(C=O)c2)c(C#N)c2ccc(Cl)cc21.NCCN1CCCC1>>Cn1c(-c2cncc(CNCCN3CCCC3)c2)c(C#N)c2ccc(Cl)cc21",
        "output": "441"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCCCN1CCOc2ccc(COC3CN(C(=O)OCc4ccccc4)CCC3c3ccc(O)cc3)cc21.Cc1ccc(S(=O)(=O)OCCCOS(=O)(=O)c2ccc(C)cc2)cc1>>COCCCN1CCOc2ccc(COC3CN(C(=O)OCc4ccccc4)CCC3c3ccc(OCCCOS(=O)(=O)c4ccc(C)cc4)cc3)cc21",
        "output": "438"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccc(Br)cc1.CC#N.CC(C)N.O=C([O-])[O-].[K+].[K+]>>CC(C)NCc1ccc(Br)cc1",
        "output": "446"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CC1(C)C=C(n2ccc(C(O)CCO)cc2=O)c2cc(C#N)ccc2O1.CCN(CC)CC.ClCCl.O=P([O-])([O-])[O-]>>CC1(C)C=C(n2ccc(C(O)CCO[Si](C)(C)C(C)(C)C)cc2=O)c2cc(C#N)ccc2O1",
        "output": "193"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.COC(=O)c1cnc(-c2cccc(F)c2)nc1.O>>O=C(O)c1cnc(-c2cccc(F)c2)nc1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1cn(-c2nccc3ccccc23)cc1C(=O)O.ClC(Cl)Cl.O=S(Cl)Cl>>Cc1cn(-c2nccc3ccccc23)cc1C(=O)Cl",
        "output": "188"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CCCS(=O)(=O)Nc1ccc(F)c(CBr)c1F.CN(C)C=O.Oc1cnc2ccccc2c1.[H-].[Na+]>>CCCS(=O)(=O)Nc1ccc(F)c(COc2cnc3ccccc3c2)c1F",
        "output": "623"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)[O-].Cc1ccccc1.Fc1ccc(Br)cc1.[Na+].[Pd+2].c1ccc2c(c1)Cc1ccccc1N2>>Fc1ccc(N2c3ccccc3Cc3ccccc32)cc1",
        "output": "894"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COCCOCCNCC(=O)OCc1ccccc1.[Pd]>>COCCOCCNCC(=O)O",
        "output": "186"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C(O)c1ccc(-c2nc(C(Cl)(Cl)Cl)nc(C(Cl)(Cl)Cl)n2)cc1.O=S(Cl)Cl>>O=C(Cl)c1ccc(-c2nc(C(Cl)(Cl)Cl)nc(C(Cl)(Cl)Cl)n2)cc1",
        "output": "3"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cl.N#Cc1ccc(CN)c(OCC(N)=O)c1.O=C(O)c1cc(Cl)cc(N2CCCS2(=O)=O)c1>>N#Cc1ccc(CNC(=O)c2cc(Cl)cc(N3CCCS3(=O)=O)c2)c(OCC(N)=O)c1",
        "output": "753"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.OCCc1ccc(F)cc1.Oc1ccc2[nH]ccc2c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Fc1ccc(CCOc2ccc3[nH]ccc3c2)cc1",
        "output": "478"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCc1cc(C(=O)c2ccccc2Cl)c(-n2c(C)nnc2CN)s1.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccc(S(=O)(=O)O)cc1.F[P-](F)(F)(F)(F)F.O=C(O)/C=C/c1ccccc1>>CCc1cc(C(=O)c2ccccc2Cl)c(-n2c(C)nnc2CNC(=O)/C=C/c2ccccc2)s1",
        "output": "767"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cn1cnc(-c2cc(Oc3ccc([N+](=O)[O-])nc3)ccn2)c1.[Pd]>>Cn1cnc(-c2cc(Oc3ccc(N)nc3)ccn2)c1",
        "output": "457"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.Cc1cc(C)nc(N2CCNCC2)n1.Cc1ccc(S(=O)(=O)OCCCCc2c[nH]c3ccc(Cl)cc23)cc1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>Cc1cc(C)nc(N2CCN(CCCCc3c[nH]c4ccc(Cl)cc34)CC2)n1",
        "output": "429"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC(=O)Cl.Cl.Nc1n[nH]c2nnc(-c3ccccc3)cc12.c1ccncc1>>CCCC(=O)Nc1n[nH]c2nnc(-c3ccccc3)cc12",
        "output": "527"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrC1CCCC1.CC#N.O.O=C([O-])[O-].O=Cc1ccc(O)cc1.[I-].[K+].[K+].[K+]>>O=Cc1ccc(OC2CCCC2)cc1",
        "output": "153"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COC(=O)c1ccc(-c2ccc(N)cc2C)cc1.Cl.ClCCl.O.O=C(Cl)CCCCl>>COC(=O)c1ccc(-c2ccc(NC(=O)CCCCl)cc2C)cc1",
        "output": "9"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.ClCCl.NS(=O)(=O)c1ccc(NC2CCNCC2)c([N+](=O)[O-])c1.O=S(=O)(Cl)c1ccccc1>>NS(=O)(=O)c1ccc(NC2CCN(S(=O)(=O)c3ccccc3)CC2)c([N+](=O)[O-])c1",
        "output": "99"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1cccc(-c2cccc(-n3c4ccccc4c4ccccc43)c2)c1.C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Fe+2].[K+].[Pd].[Pd].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2cccc(-c3cccc(-n4c5ccccc5c5ccccc54)c3)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrBr.ClCCl.O=C1CCOc2ccccc21.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C1CCOc2cc(Br)ccc21",
        "output": "98"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CC[C@H](N)CNc1ccc(OC)cc1OC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)C1(NC(c2ccccc2)C(F)(F)F)CCCCC1>>CC[C@@H](CNc1ccc(OC)cc1OC)NC(=O)C1(NC(c2ccccc2)C(F)(F)F)CCCCC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cnc(-c2ccccc2)c(-c2ccc(=O)n(C(C)C)n2)c1.ClC(Cl)Cl.O.[BH4-].[Li+]>>CC(C)n1nc(-c2cc(CO)cnc2-c2ccccc2)ccc1=O",
        "output": "522"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCc1ncnc(O)c1F.ClCCl.O=P(Cl)(Cl)Cl>>CCc1ncnc(Cl)c1F",
        "output": "168"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)N.Cc1onc(-c2ccc(F)cn2)c1CCc1ncc(C(=O)O)s1>>Cc1onc(-c2ccc(F)cn2)c1CCc1ncc(C(=O)NC(C)C)s1",
        "output": "534"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC1(C)CNCC=C1c1ccc(F)cc1.CO.[OH-].[OH-].[Pd+2]>>CC1(C)CNCCC1c1ccc(F)cc1",
        "output": "806"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cl.O=C(O)c1cc(O)nc2ccccc12>>COC(=O)c1cc(O)nc2ccccc12",
        "output": "33"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCNC[C@H]1c1ccc(Cl)c(Cl)c1.O=C(O)C1CCN(C(=O)C2CC2)CC1>>CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)C3CC3)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)N1C(CN)c2cc(-c3c[nH]c4cc(F)ccc34)ccc2S1(=O)=O.CCN(C(C)C)C(C)C.COC(=O)Cl.ClCCl>>COC(=O)NCC1c2cc(-c3c[nH]c4cc(F)ccc34)ccc2S(=O)(=O)N1C(C)(C)C",
        "output": "94"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(C(C)(C)C)C(C)(C)C.Cc1cccc(C(F)(c2cccc(C)n2)c2cccc(Br)n2)n1.OB(O)c1ccccc1O.[F-].[K+].[Pd+2]>>Cc1cccc(C(F)(c2cccc(C)n2)c2cccc(-c3ccccc3O)n2)n1",
        "output": "869"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.Cc1nc(N(c2ccccc2)c2ccccc2)c(C)c(C)c1OCc1ccccc1.[Pd]>>Cc1nc(N(c2ccccc2)c2ccccc2)c(C)c(C)c1O",
        "output": "264"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Clc1cccc(Cl)c1Br.Nc1ccccc1CS(=O)(=O)NCCOCCO.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[K+].[K+].[Pd].[Pd]>>O=S(=O)(Cc1ccccc1Nc1c(Cl)cccc1Cl)NCCOCCO",
        "output": "405"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(=O)Cl.Cc1ccc2c(N3CC[C@@H](N)C3)nc(-c3c(O)cccc3F)nc2c1.O=C([O-])Cl>>CCOC(=O)N[C@@H]1CCN(c2nc(-c3c(O)cccc3F)nc3cc(C)ccc23)C1",
        "output": "94"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C(CCl)Nc1ccccc1.O=S(=O)(O)Cl.O=S(Cl)Cl>>O=C(CCl)Nc1ccc(S(=O)(=O)Cl)cc1",
        "output": "182"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC1CN(C(=O)OC(C)(C)C)CCN1Cc1cc([N+](=O)[O-])cc2ccoc12.CCO.NN.O.[Ni]>>CC1CN(C(=O)OC(C)(C)C)CCN1Cc1cc(N)cc2ccoc12",
        "output": "71"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CS(C)=O.Cc1cccc(Cl)c1S(=O)(=O)N1CCCCC1CO.ClCCl.O=C(Cl)C(=O)Cl>>Cc1cccc(Cl)c1S(=O)(=O)N1CCCCC1C=O",
        "output": "610"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cc(N2CCC(N3CCCC3C)C2)ccc1N.O=C(O)c1ccc2cnccc2n1>>Cc1cc(N2CCC(N3CCCC3C)C2)ccc1NC(=O)c1ccc2cnccc2n1",
        "output": "548"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1ccccn1.C#CCCc1nc2ccccc2s1>>C(#Cc1ccccn1)CCc1nc2ccccc2s1",
        "output": "777"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CI.COc1ccc(CN2C(=O)[C@H]3C[C@H](O)[C@@H]2C3)cc1.[H-].[Na+]>>COc1ccc(CN2C(=O)[C@H]3C[C@H](OC)[C@@H]2C3)cc1",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCOC(CN(C(=O)CCOCCc1ccccc1)c1ccccc1)OCC.Cl.ClCCl>>O=CCN(C(=O)CCOCCc1ccccc1)c1ccccc1",
        "output": "409"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "N.O.O=[N+]([O-])c1ccc(Cl)cc1.[Na+].[O-]c1ccc(Cl)cc1>>O=[N+]([O-])c1ccc(Oc2ccc(Cl)cc2)cc1",
        "output": "299"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNCC1.COC1=C(OC)C(=O)C(Cc2cccc(C=CC(=O)O)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2cccc(C=CC(=O)N3CCCCC3)c2)=C(C)C1=O",
        "output": "517"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(C(CCC(F)(F)F)C(=O)OC(C)(C)C)cc1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)C(CCC(F)(F)F)c1ccc(CBr)cc1",
        "output": "29"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC([C@H]2C[C@@H]2CCNc2ncc([N+](=O)[O-])cn2)CC1.CO.[Pd]>>CC(C)(C)OC(=O)N1CCC([C@H]2C[C@@H]2CCNc2ncc(N)cn2)CC1",
        "output": "660"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(=O)(=O)Cl.Nc1cc(Br)cnc1Cl.c1ccncc1>>CS(=O)(=O)Nc1cc(Br)cnc1Cl",
        "output": "812"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)NC(=O)[C@@H]1CC[C@H](Nc2cc(OCCN3CCCCC3)ncc2[N+](=O)[O-])CC1.CO.Cl[Sn]Cl>>CC(C)NC(=O)[C@H]1CC[C@@H](Nc2cc(OCCN3CCCCC3)ncc2N)CC1",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O=P(Cl)(Cl)Cl.O=c1[nH]cccc1-c1ccccc1>>Clc1ncccc1-c1ccccc1",
        "output": "100"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)N(Cc1ccc(C)nc1)c1cc(OCC2CCOCC2)nc(N)c1[N+](=O)[O-].[H][H].[Pd]>>CCOC(=O)N(Cc1ccc(C)nc1)c1cc(OCC2CCOCC2)nc(N)c1N",
        "output": "269"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)O.CO.CO.Cc1c(N(Cc2ccc(C#N)cc2)Cc2ccc(Oc3cccc(C=O)c3)cc2)cccc1N(S(C)(=O)=O)S(C)(=O)=O.ClCCl.O.[BH4-].[Na+]>>Cc1c(N(Cc2ccc(C#N)cc2)Cc2ccc(Oc3cccc(CO)c3)cc2)cccc1N(S(C)(=O)=O)S(C)(=O)=O",
        "output": "356"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)Cl.Cl.Cl.Nc1ccc(O)c2c1NC(=O)CC2.[Na+].[OH-]>>CCOC(=O)Nc1ccc(O)c2c1NC(=O)CC2",
        "output": "102"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CI.CN(C)C=O.O=C(O)CCc1cccc(O)c1.O=C([O-])O.[K+]>>COC(=O)CCc1cccc(O)c1",
        "output": "415"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CCN(CC)CC.CCNC(=O)CCl.Cc1nc(-c2cn3c(n2)-c2ccc(C4CCNCC4)cc2OCC3)n(C(C)C)n1.Cl.ClCCl.[I-]>>CCNC(=O)CN1CCC(c2ccc3c(c2)OCCn2cc(-c4nc(C)nn4C(C)C)nc2-3)CC1",
        "output": "340"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(=O)Cl.Cc1[nH]c2c(-c3cc(C(F)F)ccc3OCC3CC3)ncnc2c1C(=O)N[C@@H]1C[C@@H](N)C[C@H]1F>>CCC(=O)N[C@@H]1C[C@@H](NC(=O)c2c(C)[nH]c3c(-c4cc(C(F)F)ccc4OCC4CC4)ncnc23)[C@H](F)C1",
        "output": "45"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Nc1ccccc1F.O=Cc1ccc(C(=O)O)cc1.[B][B][B][B][B][B][B][B][B][B]>>O=C(O)c1ccc(CNc2ccccc2F)cc1",
        "output": "359"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrB(Br)Br.CCOC(C)=O.COc1ccc2[nH]cc(Cn3ccnc3)c2c1.ClCCl.O>>Oc1ccc2[nH]cc(Cn3ccnc3)c2c1",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Nc1cc(F)c(F)cc1[N+](=O)[O-].CCO.Cl>>Nc1cc(F)c(F)cc1[N+](=O)[O-]",
        "output": "66"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc2c(cc1OC)C(C)N(CCc1ccc(N)cc1)CC2.Cc1ccccc1.O=CO>>COc1cc2c(cc1OC)C(C)N(CCc1ccc(NC=O)cc1)CC2",
        "output": "27"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)c1cc([N+](=O)[O-])cnc1C.NCCO>>Cc1ncc([N+](=O)[O-])cc1C(=O)NCCO",
        "output": "498"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CS(=O)(=O)c1nc2c(c(-c3ccc(Cl)cc3Cl)n1)CNCC2.ClCCl>>CC(=O)N1CCc2nc(S(C)(=O)=O)nc(-c3ccc(Cl)cc3Cl)c2C1",
        "output": "369"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCCCCCCCCCCCCCOCC(CO)(COCCCCCCCCCCCCCCCCCC)COCCCCCCCCCCCCCCCCCC.Cc1ccccc1.II.c1c[nH]cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCCCCCCCCCCCCCCCCOCC(CI)(COCCCCCCCCCCCCCCCCCC)COCCCCCCCCCCCCCCCCCC",
        "output": "670"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COCCOC.Clc1cc(Cl)ncn1.O.OB(O)c1c(F)cccc1F>>Fc1cccc(F)c1-c1cc(Cl)ncn1",
        "output": "884"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCc1cccc(C2(O)CCOCC2)n1.CCN(CC)CC.ClCCl.F.F.F>>OCc1cccc(C2(O)CCOCC2)n1",
        "output": "708"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CCc1cccc(C(=O)O)c1.NCCc1ccccc1>>CC(C)CCc1cccc(C(=O)NCCc2ccccc2)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(Oc1cc(-c2ccc(C(=O)O)cc2)cnc1N)c1c(Cl)cccc1Cl.NCCN1CCCC1>>CC(Oc1cc(-c2ccc(C(=O)NCCN3CCCC3)cc2)cnc1N)c1c(Cl)cccc1Cl",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCC.CCOC(C)=O.COCCOCCl.O.O=[N+]([O-])c1ccc(O)cc1.[H-].[Na+]>>COCCOCOc1ccc([N+](=O)[O-])cc1",
        "output": "375"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)N1CCc2c(c(N3CCc4c3ccc(-c3cnn(C)c3)c4CO[Si](C)(C)C(C)(C)C)nn2C2CCOC2)C1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>CC(=O)N1CCc2c(c(N3CCc4c3ccc(-c3cnn(C)c3)c4CO)nn2C2CCOC2)C1",
        "output": "708"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCN1.C1COCCO1.N#CC(C#N)=C1N(CCCBr)CCN1C1CCN(Cc2ccccc2)CC1.O>>N#CC(C#N)=C1N(CCCN2CCOCC2)CCN1C1CCN(Cc2ccccc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1cc(F)ccc1F.Oc1ccc(Br)cc1.[K+].[K+]>>O=[N+]([O-])c1cc(F)ccc1Oc1ccc(Br)cc1",
        "output": "564"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1cccc([C@]2(C)CCN(C(=O)OCC[Si](C)(C)C)C[C@@H]2C)c1.Cl.O.O.[Li+].[OH-]>>C[C@H]1CN(C(=O)OCC[Si](C)(C)C)CC[C@@]1(C)c1cccc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCn1cc(C2CCC3(CC2)OCCO3)c2cc(C#N)ccc21.Cn1cc(C2CCC(=O)CC2)c2cc(C#N)ccc21>>CCn1cc(C2CCC(=O)CC2)c2cc(C#N)ccc21",
        "output": "251"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)N[C@H](C)c1cncc(Br)c1.CI.ClCCl.[H-].[Na+]>>CC(=O)N(C)[C@H](C)c1cncc(Br)c1",
        "output": "83"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(C)Oc1c(C(N)=O)sc2ccc([N+](=O)[O-])cc12.[Pd]>>CC(C)Oc1c(C(N)=O)sc2ccc(N)cc12",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Fc1ccc(F)cc1.O=S(=O)(O)O.O=[N+]([O-])O>>O=[N+]([O-])c1cc(F)ccc1F",
        "output": "21"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.COc1c(Cl)ccc(-c2cc(N)c(Cl)c(C(=O)O)n2)c1F.COc1ccc(CO)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(COC(=O)c2nc(-c3ccc(Cl)c(OC)c3F)cc(N)c2Cl)cc1",
        "output": "331"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)COc1c(CCC(C)C)c(OC)cc(OC)c1C(=O)CCc1cc(OC)c(O)c(OC)c1.Cl.[K+].[OH-]>>COc1cc(CCC(=O)c2c(OC)cc(OC)c(CCC(C)C)c2OCC(=O)O)cc(OC)c1O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC1(CO[Si](C)(C)C(C)(C)C)Cc2nnc(-c3ccc(-c4ccccc4)cc3Cl)n2CCS1.CCCC[N+](CCCC)(CCCC)CCCC.O.[F-]>>CC1(CO)Cc2nnc(-c3ccc(-c4ccccc4)cc3Cl)n2CCS1",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CO.O=[N+]([O-])c1ccccc1NC1CC2CCC(C1)N2Cc1ccccc1.[Pd]>>Nc1ccccc1NC1CC2CCC(C1)N2Cc1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccccc1C.O=C([O-])[O-].[Br-].[K+].[K+].[K+].[OH-].c1cn[nH]c1>>c1ccc(Cn2cccn2)cc1",
        "output": "635"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "OCC(F)=C(c1ccc(Cl)cc1)C1CC1.[Mn+4].[O-2].[O-2]>>O=CC(F)=C(c1ccc(Cl)cc1)C1CC1",
        "output": "183"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCC/C=C\\C/C=C\\CCCCCCCCOc1cc(CO)cc(OCCCCCCCC/C=C\\C/C=C\\CCCCC)n1.CS(=O)(=O)Cl.Cl.ClCCl>>CCCCC/C=C\\C/C=C\\CCCCCCCCOc1cc(COS(C)(=O)=O)cc(OCCCCCCCC/C=C\\C/C=C\\CCCCC)n1",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCCCC1.CC(C)(C)NC(C)(C)C.ClCCCBr.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)N(CCCCl)C(C)(C)C",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClCCl.Cn1c2c(c3ccc(-n4ccc(OCc5ccccc5)cc4=O)cc31)CCCN(C(=O)OC(C)(C)C)C2.O=C(O)C(F)(F)F>>Cn1c2c(c3ccc(-n4ccc(OCc5ccccc5)cc4=O)cc31)CCCNC2",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CC[C@H](C)[C@H](N)C(=O)N1CCOCC1.CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.CO.C[C@H](NC(=O)Cc1cccc([N+](=O)[O-])c1)C(=O)O.ClC(Cl)Cl>>CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)Cc1cccc([N+](=O)[O-])c1)C(=O)N1CCOCC1",
        "output": "133"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CC1OB(O)c2cc(Oc3nnc(C(=N)NO)s3)cc(C)c21.CO.[Li+].[OH-]>>Cc1cc(Oc2nnc(C(=N)NO)s2)cc2c1C(CC(=O)O)OB2O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.C[C@H]1CN(c2ccncc2N)C[C@@H](NC(=O)OC(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C.O=C(O)c1ccc(F)c(Br)n1>>C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(Br)n2)C[C@@H](NC(=O)OC(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C",
        "output": "776"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(CN)cn1.ClCCl.Nc1ccc(S(=O)(=O)N2CCCCC2)cc1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)Nc1ccc(CNC(=O)Nc2ccc(S(=O)(=O)N3CCCCC3)cc2)cn1",
        "output": "914"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.O.O=C(CCN1CCC2(CC1)C(=O)NCN2c1ccccc1)Nc1ccc(F)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+].c1ccccc1>>O=C1NCN(c2ccccc2)C12CCN(CCCNc1ccc(F)cc1)CC2",
        "output": "112"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C1CCCC1.c1ccc(COc2ccc3c(c2)CCNCC3)cc1>>c1ccc(COc2ccc3c(c2)CCN(C2CCCC2)CC3)cc1",
        "output": "187"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CO.COc1cc2ncc(C#N)c(Nc3cccc(Br)c3)c2cc1[N+](=O)[O-].O.[Cl-].[Fe].[NH4+]>>COc1cc2ncc(C#N)c(Nc3cccc(Br)c3)c2cc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCCOCCO.N#Cc1ccc2c(c1)ncn2CCCCN1CCN(c2ccc3c(c2)OCCO3)CC1.O.[Na+].[OH-]>>NC(=O)c1ccc2c(c1)ncn2CCCCN1CCN(c2ccc3c(c2)OCCO3)CC1",
        "output": "419"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cc1ncnc2c1c(NC(C)c1ccccn1)cc(=O)n2OCc1ccccc1.[C].[H][H].[OH-].[OH-].[Pd+2]>>Cc1ncnc2c1c(NC(C)c1ccccn1)cc(=O)n2O",
        "output": "630"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc(-c2cc(C(=O)O)cnc2OCC(F)(F)F)ccc1Cl.NCc1nc(C(F)(F)F)no1>>Cc1cc(-c2cc(C(=O)NCc3nc(C(F)(F)F)no3)cnc2OCC(F)(F)F)ccc1Cl",
        "output": "674"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCn1c(Cl)nc2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O.N>>CCCn1c(N)nc2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O",
        "output": "312"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.O.O=C(OCc1ccccc1)c1cc(-c2ccncc2)ccc1OCc1ccccc1.[Li+].[OH-]>>O=C(O)c1cc(-c2ccncc2)ccc1OCc1ccccc1",
        "output": "290"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC1(C)OB(c2ccc(-c3ccccc3O)cc2)OC1(C)C.CCO.CCOC(C)=O.COC(=O)c1c[nH]c2cc(Cl)c(Br)cc12.Cc1ccccc1.Cl[Pd]Cl.O=C([O-])[O-].O=S(=O)([O-])O.[Fe+2].[K+].[K+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COC(=O)c1c[nH]c2cc(Cl)c(-c3ccc(-c4ccccc4O)cc3)cc12",
        "output": "933"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CCCCCCCN.CO.COC(OC)OC.ClCCl.O=Cc1ccc(F)cc1F.[BH4-]>>CCCCCCCNCc1ccc(F)cc1F",
        "output": "468"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)C1CCN(c2ccc(Nc3cc(NCc4ccccc4)c(CC(N)=O)cn3)cc2)CC1.NCCO>>NC(=O)Cc1cnc(Nc2ccc(N3CCC(C(=O)NCCO)CC3)cc2)cc1NCc1ccccc1",
        "output": "64"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)/C=C(\\C)c1ccc(Br)cc1.COCCOC.Cl.O=C([O-])[O-].OB(O)c1ccc(Cl)cc1.[Na+].[Na+]>>CCOC(=O)/C=C(\\C)c1ccc(-c2ccc(Cl)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN1C(=O)c2cc(CCOc3ccnc4ccccc34)cnc2N(C2CC2)c2nc(Cl)ccc21.ClCCl.O=C(OO)c1cccc(Cl)c1>>CN1C(=O)c2cc(CCOc3cc[n+]([O-])c4ccccc34)cnc2N(C2CC2)c2nc(Cl)ccc21",
        "output": "262"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@@H]1C[C@H](N)C[C@@H]1c1cnc2cnc3[nH]ccc3n12.Cc1cnc(C(=O)O)cn1.ClCCl.F[P-](F)(F)(F)(F)F>>Cc1cnc(C(=O)N[C@H]2C[C@@H](C)[C@@H](c3cnc4cnc5[nH]ccc5n34)C2)cn1",
        "output": "697"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)CCC[C@H]1CC[C@@H]2[C@@H](/C=C/[C@@H](O)COc3ccccc3)[C@H](O)C[C@@H]2S1.Cl.[Na+].[OH-]>>O=C(O)CCC[C@H]1CC[C@@H]2[C@@H](/C=C/[C@@H](O)COc3ccccc3)[C@H](O)C[C@@H]2S1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCCCC.COc1cc(F)cc(F)c1.Cl.O=C=O.[Li]CCCC>>COc1cc(F)c(C(=O)O)c(F)c1",
        "output": "387"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CCN(CC)CC.CO.COC(=O)C1CCc2ccc(Oc3cccc(N)c3)cc2C1.Cl.O=Cc1ccccc1.[BH3-]C#N.[Na+]>>COC(=O)C1CCc2ccc(Oc3cccc(NCc4ccccc4)c3)cc2C1",
        "output": "359"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C1OC(=O)C2CCCCC12.[Al+3].[Cl-].[Cl-].[Cl-].c1ccccc1>>O=C(O)C1CCCCC1C(=O)c1ccccc1",
        "output": "345"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1cc(N2CCOCC2)cc([N+](=O)[O-])c1.[Cl-].[NH4+]>>NC(=O)c1cc(N2CCOCC2)cc([N+](=O)[O-])c1",
        "output": "358"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.O=C(O)c1ccc2c(c1)OC(c1cc(Cl)cc(Cl)c1)(c1cc(Cl)cc(Cl)c1)O2>>O=C(c1ccc2c(c1)OC(c1cc(Cl)cc(Cl)c1)(c1cc(Cl)cc(Cl)c1)O2)N1CCOCC1",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.O=[N+]([O-])c1c(Cl)ccnc1Cl>>CC(C)(C)OC(=O)N1CCN(c2ccnc(Cl)c2[N+](=O)[O-])CC1",
        "output": "398"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.COc1cccc(C2(C(=O)O)CC2)c1.COc1ncc(-c2nc(N)ccc2C)cc1C.ClCCl.O=S(Cl)Cl>>COc1cccc(C2(C(=O)Nc3ccc(C)c(-c4cnc(OC)c(C)c4)n3)CC2)c1",
        "output": "368"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(Nc2cc3ccccc3c(Cl)n2)n[nH]1.OB(O)c1ccc(Cl)cc1>>Cc1cc(Nc2cc3ccccc3c(-c3ccc(Cl)cc3)n2)n[nH]1",
        "output": "865"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1nn(C)c(N)c1C#N.O=C(Cl)CCCCCl.c1ccncc1>>Cc1nn(C)c(NC(=O)CCCCCl)c1C#N",
        "output": "527"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccccc1.CCCC[N+](CCCC)(CCCC)CCCC.O=S(=O)([O-])O.O=c1cc(OCc2ccccc2)cc[nH]1.[Na+].[OH-].c1ccccc1>>O=c1cc(OCc2ccccc2)ccn1Cc1ccccc1",
        "output": "528"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.Cl[Co]Cl.N#Cc1ccccc1-n1nc(C(F)(F)F)cc1-c1ccco1.O.O=C([O-])[O-].[BH4-].[Na+].[Na+].[Na+]>>NCc1ccccc1-n1nc(C(F)(F)F)cc1-c1ccco1",
        "output": "175"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.COc1cc(-c2cnc(N3CCOCC3)cc2N)ccc1C#N.Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Cl.Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>COc1cc(-c2cnc(N3CCOCC3)cc2Nc2c(C)c(-c3ccccn3)nc3cc(F)cc(F)c23)ccc1C#N",
        "output": "115"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CCOC(=O)C(C)(C(C)=O)c1ccc(N)c(NC)c1C#N.CCOC(C)=O.ClC(Cl)Cl>>CCOC(=O)C(C)(C(C)=O)c1cc(Br)c(N)c(NC)c1C#N",
        "output": "98"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CN1CCC(c2c[nH]c3ccncc23)CC1.C[Si](C)(C)[N-][Si](C)(C)C.O=S(=O)(Cl)c1ccccc1.[Na+]>>CN1CCC(c2cn(S(=O)(=O)c3ccccc3)c3ccncc23)CC1",
        "output": "648"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cc(OCc2ccccc2)c2c(n1)c(-c1ccc(-n3cccn3)cc1C)nn2C.[H][H].[Pd]>>Cc1cc(O)c2c(n1)c(-c1ccc(-n3cccn3)cc1C)nn2C",
        "output": "264"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C)CCN(S(=O)(=O)c2ccccc2)c2cc(C(=O)O)ccc2S1.ClCCCl.O=S(Cl)Cl>>CC1(C)CCN(S(=O)(=O)c2ccccc2)c2cc(C(=O)Cl)ccc2S1",
        "output": "3"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)N.CO.COC(=O)c1ccc(OCC2CO2)cc1>>COC(=O)c1ccc(OCC(O)CNC(C)(C)C)cc1",
        "output": "16"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.O=[N+]([O-])c1ccc(Oc2ccc(Cl)cc2)cc1.O=[Pt].[H][H]>>Nc1ccc(Oc2ccc(Cl)cc2)cc1",
        "output": "335"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.O=C(O)c1cc(O)cc(OCc2ccccc2)c1>>CC(=O)Oc1cc(OCc2ccccc2)cc(C(=O)O)c1",
        "output": "108"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.COC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)OC(C)(C)C.ClCCl.N#Cc1ccc(CBr)cc1.O.[H-].[Na+]>>COC(=O)[C@H](Cc1c(C)cc(OCc2ccc(C#N)cc2)cc1C)NC(=O)OC(C)(C)C",
        "output": "127"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OCCCC(=O)Cl.CCOC(C)=O.CN(C)C=O.C[C@@H](S[C@H]1CO[C@H](/C=C/C=C/c2ccc(C#N)cc2F)OC1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F.[Cl-].[H-].[NH4+].[Na+]>>CC(=O)OCCCC(=O)O[C@@](Cn1cncn1)(c1ccc(F)cc1F)[C@@H](C)S[C@H]1CO[C@H](/C=C/C=C/c2ccc(C#N)cc2F)OC1",
        "output": "126"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)Cc1c(C)c2ccc(NS(=O)(=O)c3ccc([N+](=O)[O-])cc3C#N)cc2oc1=O.Cl.O>>Cc1c(CC(=O)O)c(=O)oc2cc(NS(=O)(=O)c3ccc([N+](=O)[O-])cc3C#N)ccc12",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)Oc1cc(I)ccc1OC(C)C.CCOCC.CO.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li+].[OH-]>>CC(C)Oc1ccc(I)cc1O",
        "output": "22"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)CNC(=O)C1=C(O)c2ccc(-c3cccnc3)cc2C(C)(C)C1=O.O=C(O)C(F)(F)F>>CC1(C)C(=O)C(C(=O)NCC(=O)O)=C(O)c2ccc(-c3cccnc3)cc21",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.C[Si](C)(C)CCOCCl.ClC(Cl)Cl.O.O=[N+]([O-])c1ccc(-c2cc[nH]n2)cc1>>C[Si](C)(C)CCOCn1ccc(-c2ccc([N+](=O)[O-])cc2)n1",
        "output": "910"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(O)c1ncc(NC(=O)OC(C)(C)C)cc1Cl.CO.Cl>>CC(O)c1ncc(N)cc1Cl",
        "output": "877"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.Clc1cc(Cl)nc(Cl)n1.Oc1c(Cl)cccc1Cl.[K+].[OH-]>>Clc1cc(Oc2c(Cl)cccc2Cl)nc(Cl)n1",
        "output": "668"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.Cc1nnc(C(S)C2=C(C(=O)O)N3C(=O)C(N)[C@H]3SC2)s1.Cc1noc(CC(=O)O)n1>>Cc1noc(CC(=O)NC2C(=O)N3C(C(=O)O)=C(C(S)c4nnc(C)s4)CS[C@H]23)n1",
        "output": "133"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.CC(C)Oc1ncc(F)c(NC2CC(C)(C)NC(C)(C)C2)n1.CC(C)c1cc(F)c(N)cc1-n1cnnn1.CC1(C)CC(Nc2nc(Cl)ncc2C#N)CC(C)(C)N1.Cc1ccc(S(=O)(=O)O)cc1.O>>CC(C)c1cc(F)c(Nc2ncc(C#N)c(NC3CC(C)(C)NC(C)(C)C3)n2)cc1-n1cnnn1",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CC(=O)c1ccccc1-c1ccc(Cl)cc1F.CO.[BH3-]C#N.[NH4+].[Na+]>>CC(N)c1ccccc1-c1ccc(Cl)cc1F",
        "output": "552"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)C1(Cc2ccccc2)NC(=O)C(CC(C)C)N(OCc2ccccc2)C1=O.CCOC(C)=O.Cl.O.[Na+].[OH-]>>CC(C)CC1C(=O)NC(Cc2ccccc2)(C(=O)O)C(=O)N1OCc1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CNCCN1.CCCCO.CCN(C(C)C)C(C)C.Cc1ccc(-c2cnc(Nc3cccc(Cl)n3)s2)cn1>>Cc1ccc(-c2cnc(Nc3cccc(N4CCNCC4)n3)s2)cn1",
        "output": "220"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCNCCNc1cc(N2CCS(=O)(=O)c3ccccc3C2)nc2ccc(C)cc12.O=C1COC1>>CCN(CCNc1cc(N2CCS(=O)(=O)c3ccccc3C2)nc2ccc(C)cc12)C1COC1",
        "output": "983"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COc1cc2c(c3c1OC(C)(C)C3)C(c1cccc(C(=O)NCC(=O)O)c1)=NC(C)(C)C2.Cl.Cl.Nc1ccccc1.O.O=C([O-])O.On1nnc2ccccc21.[Na+]>>COc1cc2c(c3c1OC(C)(C)C3)C(c1cccc(C(=O)NCC(=O)Nc3ccccc3)c1)=NC(C)(C)C2",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.ClC(Cl)Cl.NCc1cc2c(cn1)OCCO2.O=C1CCc2cc(Br)ccc2C1.[Na+]>>Brc1ccc2c(c1)CCC(NCc1cc3c(cn1)OCCO3)C2",
        "output": "236"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN1CC=C(c2c[nH]c3ccncc23)CC1.C[Si](C)(C)[N-][Si](C)(C)C.O=C(Cl)c1c(Cl)cccc1Cl.[Na+]>>CN1CC=C(c2cn(C(=O)c3c(Cl)cccc3Cl)c3ccncc23)CC1",
        "output": "232"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCOc1cccc(-c2noc3ccsc23)c1.CC#N.NC12CC3CC(CC(C3)C1)C2.O=C([O-])[O-].[K+].[K+]>>c1cc(OCCCNC23CC4CC(CC(C4)C2)C3)cc(-c2noc3ccsc23)c1",
        "output": "147"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(Br)cc1C=O.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.OCCO>>Cc1ccc(Br)cc1C1OCCO1",
        "output": "117"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)CC(CNc2nc(F)ccc2F)CCO1.CCOC(C)=O.CO.C[O-].Cl.O.O=C([O-])O.[Cl-].[Na+].[Na+].[Na+]>>COc1ccc(F)c(NCC2CCOC(C)(C)C2)n1",
        "output": "541"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN1CCNCC1.N#CCBr>>CCN1CCN(CC#N)CC1",
        "output": "880"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.ClCCl.NC(=O)c1cc2c(O)cc(F)cc2n1Cc1ccccc1.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>NC(=O)c1cc2c(OS(=O)(=O)C(F)(F)F)cc(F)cc2n1Cc1ccccc1",
        "output": "731"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCc1cc(-c2ccc(Br)cc2)no1.Fc1ccccc1-c1nc2cn[nH]cc-2n1>>Fc1ccccc1-c1nc2cnn(Cc3cc(-c4ccc(Br)cc4)no3)cc-2n1",
        "output": "997"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Cl.NCCCCCCCCCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1.O=C(O)c1ccc(F)c(O)c1.O=C([O-])O.[Na+]>>O=C(Nc1ccccc1-c1ccccc1)OC1CCN(CCCCCCCCCNC(=O)c2ccc(F)c(O)c2)CC1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)I.CS(C)=O.O.O=C([O-])[O-].Oc1ccc(Br)cc1.[K+].[K+]>>CC(C)Oc1ccc(Br)cc1",
        "output": "318"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O=C(O)C=Cc1ccc(O)c(O)c1.O=S(Cl)Cl>>COC(=O)C=Cc1ccc(O)c(O)c1",
        "output": "174"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.O=C1Nc2ccccc2C(c2ccccc2)N1CC1CCCN1Cc1ccccc1.O=C[O-].[C].[NH4+].[Pd]>>O=C1Nc2ccccc2C(c2ccccc2)N1CC1CCCN1",
        "output": "84"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.ClCCl.NCCc1ccccn1.O=C([O-])O.O=S(=O)(Cl)c1ccc(Br)cc1.[Na+]>>O=S(=O)(NCCc1ccccn1)c1ccc(Br)cc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OCCCCOc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl.CO.Cl.O.[Na+].[OH-]>>OCCCCOc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCN=C=NCCCN(C)C.Nc1cccnc1.O=C(O)Cn1nnc2c(N3CCOCC3)nc(-c3cccc(CO)c3)nc21>>O=C(Cn1nnc2c(N3CCOCC3)nc(-c3cccc(CO)c3)nc21)Nc1cccnc1",
        "output": "724"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.CSc1nc(Cl)c(C#N)c(Cl)n1.Nc1cccc(-c2ncccc2F)c1.O>>CSc1nc(Cl)c(C#N)c(Nc2cccc(-c3ncccc3F)c2)n1",
        "output": "161"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=CCBr.O.OC(c1cccnc1)c1cccc2ccccc12.[H-].[Na+]>>C=CCOC(c1cccnc1)c1cccc2ccccc12",
        "output": "120"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.CC1CC(=O)NN=C1c1ccc(NCCN)c([N+](=O)[O-])c1.ClCCl>>CC(=O)NCCNc1ccc(C2=NNC(=O)CC2C)cc1[N+](=O)[O-]",
        "output": "339"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)Cc1nc(-c2ccc(C)cc2)oc1-c1ccco1.CO.O.[Na+].[OH-]>>Cc1ccc(-c2nc(CC(=O)O)c(-c3ccco3)o2)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)c1cc2ccc([N+](=O)[O-])cc2[nH]1.CCOC(C)=O.CN(C)C=O.O=P(Cl)(Cl)Cl>>CC(C)c1[nH]c2cc([N+](=O)[O-])ccc2c1C=O",
        "output": "266"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc(-c2nn(C3CCN(C4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1NC(=O)OC(C)(C)C.ClCCl.ClCCl.O=C(O)C(F)(F)F>>COc1cc(-c2nn(C3CCN(C4CCN(C)CC4)CC3)c3ncnc(N)c23)ccc1N",
        "output": "782"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cn(Cc2ccccc2)nc1OCc1ccc(OCc2nc(-c3ccco3)oc2C)c(-c2ccccc2)c1.Cl.O.[Na+].[OH-]>>Cc1oc(-c2ccco2)nc1COc1ccc(COc2nn(Cc3ccccc3)cc2C(=O)O)cc1-c1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.COC(=O)c1ccccc1NC(C(=O)O)c1ccc(OC)nc1.O.O[C@H]1CN2CCC1CC2.On1nnc2ccccc21>>COC(=O)c1ccccc1NC(C(=O)O[C@H]1CN2CCC1CC2)c1ccc(OC)nc1",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CNCCC#Cc1ccccn1.O=C(Cl)c1ccc(F)cc1>>CN(CCC#Cc1ccccn1)C(=O)c1ccc(F)cc1",
        "output": "201"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.Cn1c(=O)[nH]c2cc([N+](=O)[O-])ccc21.[H][H].[Pd]>>Cn1c(=O)[nH]c2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CC2(CC(O)C2)C1.CCN(CC)CC.CN(C)c1ccncc1.CS(=O)(=O)Cl.ClCCl.[Cl-].[NH4+]>>CC(C)(C)OC(=O)N1CC2(CC(OS(C)(=O)=O)C2)C1",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCOC(=O)Cc1ccc(N)cc1.II.O.O=C([O-])O.[Na+]>>CCOC(=O)Cc1ccc(N)c(I)c1",
        "output": "372"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(Cl)c4)c3)c3cc(-c4cccc(NS(C)(=O)=O)c4)cnc32)cc1.O.[Li+].[OH-]>>CS(=O)(=O)Nc1cccc(-c2cnc3[nH]cc(-c4cnn(Cc5cccc(Cl)c5)c4)c3c2)c1",
        "output": "949"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1ccc(-n2cccn2)cc1.C1CCOC1.CC#N.Cc1ccc(B(O)O)cc1.O=C([O-])[O-].[Na+].[Na+]>>Cc1ccc(-c2ccc(-n3cccn3)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CCO.NN.O.O.O=C(O)C(F)(F)F.O=C1Cc2cc([N+](=O)[O-])ccc2N1.O=C1Cc2ccccc2N1.O=C1Nc2ccccc2C1=O.O=S(=O)(O)O.O=[N+]([O-])O.O=[N+]([O-])[O-].S.[Cl-].[Fe].[NH4+].[Na+].[O-][I+2]([O-])O.c1ccncc1>>Nc1ccc2c(c1)CC(=O)N2",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.COc1ccc2c(CBr)cc(=O)oc2c1.C[C@@H](C(=O)N[C@@H]1C(=O)Nc2ccccc2N(C(=O)CS(C)(=O)=O)[C@H]1C)N(C)C(=O)OC(C)(C)C.O=C([O-])[O-].[Cs+].[Cs+].[I-].[Na+]>>COc1ccc2c(CN3C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)[C@H](C)N(C(=O)CS(C)(=O)=O)c4ccccc43)cc(=O)oc2c1",
        "output": "688"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1noc(C)c1-c1cnc2c(c1)c(CC1CCNCC1)cn2C.O.O=S(=O)(Cl)c1ccccc1.c1ccncc1>>Cc1noc(C)c1-c1cnc2c(c1)c(CC1CCN(S(=O)(=O)c3ccccc3)CC1)cn2C",
        "output": "99"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CCOCC.CN(C)C=O.O=C(O)Cc1ccc(CO)cc1.O=C([O-])[O-].[Na+].[Na+]>>O=C(Cc1ccc(CO)cc1)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.COc1cc(F)c(C2CCCCC2)c(OC)c1.[I-]>>Oc1cc(O)c(C2CCCCC2)c(F)c1",
        "output": "20"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cccc(C(=O)O)c1.N[C@H]1CO[C@H]2[C@@H]1OC[C@@H]2n1cc(CC2CCCCC2)nn1>>Cc1cccc(C(=O)N[C@H]2CO[C@H]3[C@@H]2OC[C@@H]3n2cc(CC3CCCCC3)nn2)c1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(Cl)c2occc12.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>Clc1ccc(CBr)c2ccoc12",
        "output": "29"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.CS(=O)(=O)c1ccccc1[N+](=O)[O-].O=S(=O)(O)O.[Pd]>>CS(=O)(=O)c1ccccc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCCCCC.CCCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCC(=O)OCC.Cl.[H-]>>CCCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO",
        "output": "225"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1nc2c(C)cc(-c3nc4cc(F)ccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCc1nc2c(C)cc(-c3nc4cc(F)ccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NCCCO.O=C(O)c1cc2ccccc2[nH]1>>O=C(NCCCO)c1cc2ccccc2[nH]1",
        "output": "137"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cl.N#Cc1ccc(CN)c(OCC(N)=O)c1.O=C(O)c1cc(Cl)cc(OCc2ccc(Cl)cc2)c1>>N#Cc1ccc(CNC(=O)c2cc(Cl)cc(OCc3ccc(Cl)cc3)c2)c(OCC(N)=O)c1",
        "output": "753"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)[C@H](CCCCNC(=O)/C=C/C=C/c1cc(OC)c(OC)c(OC)c1)NC(=O)/C=C/C=C/c1cc(OC)c(OC)c(OC)c1.Cl.[K+].[OH-]>>COc1cc(/C=C/C=C/C(=O)NCCCC[C@H](NC(=O)/C=C/C=C/c2cc(OC)c(OC)c(OC)c2)C(=O)O)cc(OC)c1OC",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)C(N=[N+]=[N-])CC1.ClCCl.O=C(O)C(F)(F)F>>[N-]=[N+]=NC1CCNCCC1O",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.C[C@@H]1CNCCN1c1nc(-c2ccc(F)c(F)c2)c(-c2ccc(C(F)(F)F)cc2)[nH]1.C[Si](C)(C)CCOCOCc1cnc(Cl)c(Cl)c1>>C[C@@H]1CN(c2ncc(COCOCC[Si](C)(C)C)cc2Cl)CCN1c1nc(-c2ccc(F)c(F)c2)c(-c2ccc(C(F)(F)F)cc2)[nH]1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].CCOCC.COc1ccc(Br)cn1.[Na+]>>COc1ncc(Br)cc1Br",
        "output": "292"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#C[C@]1(O)CCN(C)C1=O.COC(=O)c1nn(-c2cccc(Br)c2)c2ccc(CN3CCCC3)cc12>>COC(=O)c1nn(-c2cccc(C#C[C@]3(O)CCN(C)C3=O)c2)c2ccc(CN3CCCC3)cc12",
        "output": "659"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccc2cccnc2c1-c1cc(F)cc(F)c1.CO.[BH4-].[Na+]>>CC(O)c1ccc2cccnc2c1-c1cc(F)cc(F)c1",
        "output": "24"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CCNCCN1CCCc2[nH]c(C=O)c(C)c2C1=O.CCO.O=C1Cc2cc(F)ccc2N1>>CCNCCN1CCCc2[nH]c(/C=C3\\C(=O)Nc4ccc(F)cc43)c(C)c2C1=O",
        "output": "911"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1OCOCOCCC#N.CO.COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1.c1ccncc1>>COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(NC(C)=O)ncnc43)[C@H](OCOCOCCC#N)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1",
        "output": "250"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC1CN(C2=CC(=O)OC2)C(=O)C12CCN(C(=O)OC(C)(C)C)CC2.ClCCl.O=C(O)C(F)(F)F>>COC1CN(C2=CC(=O)OC2)C(=O)C12CCNCC2",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.CCN(C(C)C)C(C)C.CN(C)C=O.CNCC(O)c1cccnc1.Cc1c(CCl)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12.O>>Cc1c(CN(C)CC(O)c2cccnc2)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12",
        "output": "639"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1cccc(I)c1.CC(C)(C)[O-].O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Fe+2].[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc2c(c1)[nH]c1ccccc12>>Brc1cccc(-n2c3ccccc3c3ccccc32)c1",
        "output": "267"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)CCc1ccc(OCCOC)cc1OCc1ccccc1.CO.Cc1ccccc1.[H-]>>COCCOc1ccc(CCCO)c(OCc2ccccc2)c1",
        "output": "225"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)N1CCC(=O)CC1.NCc1ccccc1.[Na+]>>CC(C)(C)N1CCC(NCc2ccccc2)CC1",
        "output": "589"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCC(CO)CC2)n1.ClCCl.O=S(=O)=O.c1ccncc1>>Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCC(C=O)CC2)n1",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCN(C(=O)C1CCCCC1C(=O)O)c1ccc(-n2ccnc2)cc1.O=S(Cl)Cl>>CCCN(C(=O)C1CCCCC1C(=O)Cl)c1ccc(-n2ccnc2)cc1",
        "output": "53"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1CCCN1.Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)O)cn1>>Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)N2CCCC2C)cn1",
        "output": "256"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)[C@H](C)N)c1.Cc1ccc(C(=O)O)s1>>COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)[C@H](C)NC(=O)c2ccc(C)s2)c1",
        "output": "736"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)c1ccncc1.O[C@@H]1CN2C[C@H]1Nc1nc(Cl)ccc12>>CC(C)(C)[Si](C)(C)O[C@@H]1CN2C[C@H]1Nc1nc(Cl)ccc12",
        "output": "193"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(N)CC(=O)O.CN(C)C=O.COC(=O)c1ncc2cc(Oc3ccccc3)ccc2c1O.C[O-].Cl.O.[Na+]>>CC(C)(CC(=O)O)NC(=O)c1ncc2cc(Oc3ccccc3)ccc2c1O",
        "output": "487"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1Oc1ccc(C(=O)O)cc1.NCc1ccccn1>>Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1Oc1ccc(C(=O)NCc2ccccn2)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc(S(C)(=O)=O)cc1N.ClC(Cl)Cl>>CS(=O)(=O)c1ccc(O)c(N)c1",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1cc(Br)ccc1C(N)c1ccccc1.Cc1noc(C)c1[C@H](O)c1cc2cc(CC(=O)O)ccc2o1.ClCCl.F[P-](F)(F)(F)(F)F>>Cc1cc(Br)ccc1C(NC(=O)Cc1ccc2oc([C@@H](O)c3c(C)noc3C)cc2c1)c1ccccc1",
        "output": "769"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc(C#N)c(/C=C/c2ccc(C)cc2)c(C#N)c1O.COc1cc(C#N)c(Br)c(C#N)c1O.Cc1ccc(/C=C/B(O)O)cc1>>Cc1ccc(/C=C/c2c(C#N)cc(O)c(O)c2C#N)cc1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC#N.CC(=O)[O-].CO.COC1CCN(c2c(C(C)=O)cc(Cl)c3cccnc23)C1.[BH3-]C#N.[NH4+].[Na+]>>COC1CCN(c2c(C(C)N)cc(Cl)c3cccnc23)C1",
        "output": "552"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CCCCC(N)CCCCN(CC)CC.Clc1ccc2c(Cl)ccnc2c1.O=C([O-])O.[Na+]>>CCN(CC)CCCCC(CCCCN(CC)CC)Nc1ccnc2cc(Cl)ccc12",
        "output": "78"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(C3CCN(CCOC4CCCCO4)CC3)cc1OCC2.CO.Cl>>CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(C3CCN(CCO)CC3)cc1OCC2",
        "output": "543"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cn1ncc2c(N)cccc21.Nc1cccc2[nH]ncc12.O=C=NCc1ccc(N2CCCC2)cc1>>Cn1ncc2c(NC(=O)NCc3ccc(N4CCCC4)cc3)cccc21",
        "output": "888"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#C[Si](C)(C)C.CCN(CC)CC.CS(=O)(=O)c1cc(Cl)c(N)c(I)c1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>C[Si](C)(C)C#Cc1cc(S(C)(=O)=O)cc(Cl)c1N",
        "output": "826"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCC(C)(C)C1CCC(Oc2ccc3cc([C@](C)(COP(=O)(O)O)NC(=O)OC(C)(C)C)ccc3c2C(F)(F)F)CC1.Cl>>CCC(C)(C)C1CCC(Oc2ccc3cc([C@@](C)(N)COP(=O)(O)O)ccc3c2C(F)(F)F)CC1",
        "output": "793"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)c1c(N)sc2c1CCCC2=O.[Na+].[OH-]>>Nc1sc2c(c1C(=O)O)CCCC2=O",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#Cc1cnn(C)c1.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Nc1cc(Br)ncc1I.[Cu]I>>Cn1cc(C#Cc2cnc(Br)cc2N)cn1",
        "output": "819"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CC(C)(C)OC(=O)N[C@@H](CC(=O)O)Cc1ccc(Br)cc1.CN(C)C=O.O.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N[C@@H](CC(=O)OCc1ccccc1)Cc1ccc(Br)cc1",
        "output": "403"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCc1ccc(OC(C)CCCOc2ccc(CCC(=O)OC)c(C)c2)c(C(=O)c2ccccc2)c1.CO.Cl.O.[Na+].[OH-]>>CCc1ccc(OC(C)CCCOc2ccc(CCC(=O)O)c(C)c2)c(C(=O)c2ccccc2)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NCCCCN1CCN(c2nc(C(=O)O)c(OCc3ccccc3)c3ncccc23)CC1.CCN(C(C)C)C(C)C.CCOC(=O)c1cc(F)ccc1CN.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>CCOC(=O)c1cc(F)ccc1CNC(=O)c1nc(N2CCN(CCCCNC(=O)OC(C)(C)C)CC2)c2cccnc2c1OCc1ccccc1",
        "output": "905"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)CCCCc1ccc(O)cc1Cl.Cl.[Na+].[OH-]>>O=C(O)CCCCc1ccc(O)cc1Cl",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCc1cc(-c2cccc(C(=O)CC(=O)Nc3cc(C(F)(F)F)c(C)cc3NC(=O)OC(C)(C)C)c2)cc(C)n1.ClCCl.O=C(O)C(F)(F)F>>CCc1cc(-c2cccc(C3=Nc4cc(C)c(C(F)(F)F)cc4NC(=O)C3)c2)cc(C)n1",
        "output": "930"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=Cc1cc2cc(O)c(Cl)c(Cl)c2s1.[BH4-].[Cl-].[Na+].[Na+]>>OCc1cc2cc(O)c(Cl)c(Cl)c2s1",
        "output": "529"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COCC(=O)Cl.Cc1[nH]c2c(-c3cc(C(F)F)ccc3OCC3CC3)ncnc2c1C(=O)N[C@@H]1CC[C@@H](N)CC1.Cl>>COCC(=O)N[C@@H]1CC[C@@H](NC(=O)c2c(C)[nH]c3c(-c4cc(C(F)F)ccc4OCC4CC4)ncnc23)CC1",
        "output": "45"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCC.Cc1cc(C=O)c(O)c([Si](C(C)C)(C(C)C)C(C)C)c1.Cl.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1cc(CO)c(O)c([Si](C(C)C)(C(C)C)C(C)C)c1",
        "output": "356"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C(Cc1ccccc1)CS(=O)(=O)C1CCCCC1.Cl>>O=C(O)C(Cc1ccccc1)CS(=O)(=O)C1CCCCC1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COc1cc(CCN(C(=O)OC(C)(C)C)[C@@H](C)c2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)cc2)c(Cl)cc1[N+](=O)[O-].[Cl-].[NH4+].[Zn]>>COc1cc(CCN(C(=O)OC(C)(C)C)[C@@H](C)c2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)cc2)c(Cl)cc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCCBr.O=C(c1ccccc1O)c1cccc2[nH]ccc12>>O=C(c1ccccc1OCCCCl)c1cccc2[nH]ccc12",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CS(=O)(=O)Cl.Cc1ccccc1NC(=O)CN1C[C@@H](C)N(S(=O)(=O)c2cccc(N)c2)[C@@H](C)C1.O.O=C([O-])[O-].[K+].[K+]>>Cc1ccccc1NC(=O)CN1C[C@@H](C)N(S(=O)(=O)c2cccc(NS(C)(=O)=O)c2)[C@@H](C)C1",
        "output": "194"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cc(Nc2ncnc3cccc(F)c23)ccc1O.NCCO>>Cc1cc(Nc2ncnc3cccc(OCCN)c23)ccc1O",
        "output": "958"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCOC(=O)C1CC(n2c(=O)c3c(C)onc3c3c(Cl)cccc32)CN(C(=O)OC(C)(C)C)C1.O.[Li+].[OH-]>>Cc1onc2c1c(=O)n(C1CC(C(=O)O)CN(C(=O)OC(C)(C)C)C1)c1cccc(Cl)c21",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.CN(C)C=O.ClCCl.O=S(Cl)Cl>>CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)Cl",
        "output": "53"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)c1cn(CCc2ccccc2)c2c(C)cccc12.Cl.[Na+].[OH-]>>Cc1cccc2c(C(=O)O)cn(CCc3ccccc3)c12",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccccc1OCC1CO1.O=C1C(=O)c2ccccc2C2=C1SCC1(CCNCC1)O2>>Cc1ccccc1OCC(O)CN1CCC2(CC1)CSC1=C(O2)c2ccccc2C(=O)C1=O",
        "output": "76"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Brc1ccccn1.C#CCCn1nc2ccccn2c1=O>>O=c1n(CCC#Cc2ccccn2)nc2ccccn12",
        "output": "777"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(C(N)=O)c4OC)c4ccccc34)ccn2)ccc1C(=O)O.F[P-](F)(F)(F)(F)F.NCCN1CCOCC1.O>>COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(C(N)=O)c4OC)c4ccccc34)ccn2)ccc1C(=O)NCCN1CCOCC1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Nc1ccccc1C(=O)O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c([N+](=O)[O-])c1.[Na+].[Na+]>>O=C(O)c1ccccc1Nc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]",
        "output": "609"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CCCCC1CC1(c1ccc(OC)cc1)c1ccc(OC)cc1.ClCCl>>CCCCC1CC1(c1ccc(O)cc1)c1ccc(O)cc1",
        "output": "20"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.C=C(C)C.ClCCl.O.O=C(O)C1C=CCn2c(=O)n(CCCl)c(=O)n21.O=S(=O)(O)O>>CC(C)(C)OC(=O)C1C=CCn2c(=O)n(CCCl)c(=O)n21",
        "output": "511"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)CC1CCc2c1[nH]c1ccc(-c3noc(-c4cccc(C(F)(F)F)c4)n3)cc21.CO.[Na+].[OH-]>>O=C(O)CC1CCc2c1[nH]c1ccc(-c3noc(-c4cccc(C(F)(F)F)c4)n3)cc21",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)CCN(C(C)=O)C1c2ccccc2-c2ccccc21.O.[Na+].[OH-]>>CC(=O)N(CCC(=O)O)C1c2ccccc2-c2ccccc21",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)Cc1ccc(N)cc1.CCOC(C)=O.CN1CCCC1=O.O.O=[N+]([O-])c1cc(Br)ccc1F>>CCOC(=O)Cc1ccc(Nc2ccc(Br)cc2[N+](=O)[O-])cc1",
        "output": "609"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)N1c2ccc(Br)c(OC3CCC3)c2CC[C@@H]1C.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COC(=O)N1c2ccc(B3OC(C)(C)C(C)(C)O3)c(OC3CCC3)c2CC[C@@H]1C",
        "output": "942"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Nc1ccc(F)cc1N.O=C(O)CCl.O=C([O-])O.[Na+]>>Fc1ccc2[nH]c(CCl)nc2c1",
        "output": "512"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Nc1nc(CCCO)cs1.ClC(Cl)Cl.O=C([O-])O.O=S(Cl)Cl.[Na+]>>CC(=O)Nc1nc(CCCCl)cs1",
        "output": "96"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1CCN(CC(=O)O)CC1.COc1cccc2c1C(Nc1ccc3cc(N)ccc3n1)CO2>>COc1cccc2c1C(Nc1ccc3cc(NC(=O)CN4CCN(C)CC4)ccc3n1)CO2",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCC.COC(=O)c1ccc(CCc2ccc(OC)cc2)o1.O.[Na+].[OH-]>>COc1ccc(CCc2ccc(C(=O)O)o2)cc1",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(=O)(=O)Oc1ccc(F)cc1Cl.O=S(=O)(O)O.O=[N+]([O-])O>>CS(=O)(=O)Oc1cc([N+](=O)[O-])c(F)cc1Cl",
        "output": "21"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=O.CO.COc1c(N2CCNCC2)cc(S(=O)(=O)n2cc(C(F)F)c3ccc(F)cc32)c2ccccc12.[BH3-]C#N.[Na+]>>COc1c(N2CCN(C)CC2)cc(S(=O)(=O)n2cc(C(F)F)c3ccc(F)cc32)c2ccccc12",
        "output": "217"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)CN1CCc2c(C(=O)NCCn3cc(C(c4ccccc4)c4ccccc4)ccc3=O)cccc21.O=C(O)C(F)(F)F>>O=C(O)CN1CCc2c(C(=O)NCCn3cc(C(c4ccccc4)c4ccccc4)ccc3=O)cccc21",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COc1ccc2[nH]cc(C=O)c2c1.Cc1ccccc1.N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1.O=S(=O)([O-])[O-].[BH4-].[Mg+2].[Na+]>>COc1ccc2[nH]cc(CN[C@H]3CCN(C(=O)c4cc(Cl)cc(Cl)c4)[C@H](Cc4ccccc4)C3)c2c1",
        "output": "441"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1C(=O)CC[C@]2(C)c3ccc(Br)cc3CC[C@@H]12.COc1ccc(B(O)O)cc1OC.ClC(Cl)Cl.O=C([O-])[O-].[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(-c2ccc3c(c2)CC[C@H]2N(C)C(=O)CC[C@]32C)cc1OC",
        "output": "837"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCCC12CCN(c1ccccc1Cl)C2=O.Cl>>O=C1N(c2ccccc2Cl)CCC12CCCN2",
        "output": "634"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(C(C)C)C(C)C.Fc1ccccc1N1CCNCC1.O=CCCc1cc(-c2cccs2)n(-c2ccccc2)n1.[Na+]>>Fc1ccccc1N1CCN(CCCc2cc(-c3cccs3)n(-c3ccccc3)n2)CC1",
        "output": "484"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.Clc1ncnc2ccccc12.NCCSc1ccc(Br)cc1.c1ccccc1>>Brc1ccc(SCCNc2ncnc3ccccc23)cc1",
        "output": "110"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1cccc(C(C)C)n1.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)c1cccc(CO)n1",
        "output": "711"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(CN2CCCCC2)cc1C.O.O.[Li+].[OH-]>>Cc1cc(CN2CCCCC2)ccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCC(=O)n1ccc2cc(/C=C/C(c3cc(Cl)c(F)c(Cl)c3)C(F)(F)F)ccc21.ClCCl.O=C(O)C(F)(F)F>>NCC(=O)n1ccc2cc(/C=C/C(c3cc(Cl)c(F)c(Cl)c3)C(F)(F)F)ccc21",
        "output": "431"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CCN(CC)CC.CN(C)C=O.O.O=C(O)C1CCN(C(=O)c2ccccc2)CC1.[BH4-].[Na+]>>O=C(c1ccccc1)N1CCC(CO)CC1",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "N#Cc1ccc2n1CCNC2.O=C(O)c1cc2ncc(Cl)cn2n1>>N#Cc1ccc2n1CCN(C(=O)c1cc3ncc(Cl)cn3n1)C2",
        "output": "663"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)OC.Nc1nc(C2CC2)nc(C(=O)O)c1Cl.O.O.[Na+].[OH-]>>COC(=O)c1nc(C2CC2)nc(N)c1Cl",
        "output": "195"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)O)c(C)c1.Cl.Cl.ClCCl.O=C([O-])O.OC1(Cc2ccncc2)CCNCC1.[Na+]>>COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(O)(Cc3ccncc3)CC2)c(C)c1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COC(=O)c1ccc(Cl)nc1.Nc1ccccc1.O>>COC(=O)c1ccc(Nc2ccccc2)nc1",
        "output": "434"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)C1(c2ccccc2OCCCCBr)C(=O)N(C)c2ccccc21.COc1cc(CN2CCNCC2)cc(OC)c1OC>>COc1cc(CN2CCN(CCCCOc3ccccc3C3(C(C)C)C(=O)N(C)c4ccccc43)CC2)cc(OC)c1OC",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.CS(=O)(=O)Cl.Cl.O.O=C1CCNCC1>>CS(=O)(=O)N1CCC(=O)CC1",
        "output": "584"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)[O-].Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=Cc1cc(Br)ccc1O.[Na+].[Pd]>>CC(C)(C)OC(=O)N1CCN(c2ccc(O)c(C=O)c2)CC1",
        "output": "294"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)=O.CCOC(=O)c1cnc(Cl)cc1NCc1ccc(OC)c(Cl)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1ccc(CNc2cc(Cl)ncc2CO)cc1Cl",
        "output": "383"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(=O)O.COC(=O)c1ccc2c(c1)CC(=O)N2C1CCN(C(=O)OCc2ccccc2)CC1.O.[Na+].[OH-]>>O=C(O)c1ccc2c(c1)CC(=O)N2C1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CO.ClCCl.Nc1nc(=O)n([C@H]2O[C@@H](CO)C[C@H]2O)cc1F.O=C([O-])O.[Na+].c1ccncc1>>CC(C)(C)[Si](C)(C)OC[C@H]1C[C@@H](O)[C@@H](n2cc(F)c(N)nc2=O)O1",
        "output": "193"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CI.CN(C)C=O.COc1ccc(CN(CCCCCCC(=O)O)c2ccc(Br)cc2C=O)cc1.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)CCCCCCN(Cc1ccc(OC)cc1)c1ccc(Br)cc1C=O",
        "output": "415"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCCc1c(OC)ccc2cc(C(=O)Nc3ccc(CNC(=O)OC(C)(C)C)cc3)c(=O)oc12.CO.Cl.ClCCl.ClCCl.O>>CCCc1c(OC)ccc2cc(C(=O)Nc3ccc(CN)cc3)c(=O)oc12",
        "output": "793"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Oc1ccc(-c2noc(C3(CO)CC3)c2-c2ccccc2)cc1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>OCC1(c2onc(-c3ccc(O)cc3)c2-c2ccccc2)CC1",
        "output": "754"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1cn(-c2ccc(F)cc2)c2cc(Cl)c(F)cc2c1=O.Cl.O.[Na+].[OH-]>>O=C(O)c1cn(-c2ccc(F)cc2)c2cc(Cl)c(F)cc2c1=O",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(Nc1ccc(C(N)=O)c(F)c1)C(=O)O.CI.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>COC(=O)C(C)(C)Nc1ccc(C(N)=O)c(F)c1",
        "output": "415"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1cc(Nc2nc(Nc3cc(C)c(C4CCNCC4)cc3F)ncc2Cl)n[nH]1.ClCCl.O=C1CCOCC1.[BH3-]C#N.[Na+]>>Cc1cc(Nc2nc(Nc3cc(C)c(C4CCN(C5CCOCC5)CC4)cc3F)ncc2Cl)n[nH]1",
        "output": "187"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)Cc1cc(OC(F)F)ccn1.N>>NC(=O)Cc1cc(OC(F)F)ccn1",
        "output": "432"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CS(C)=O.N#Cc1ccc(S(=O)(=O)N2CCc3cc(Br)ccc32)cc1.O.[Cl-].[K+].[Na+]>>CC1(C)OB(c2ccc3c(c2)CCN3S(=O)(=O)c2ccc(C#N)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1[nH]c(C)nc1C.CO.[Li+].[OH-]>>Cc1nc(C)c(C(=O)O)[nH]1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)O.CCOC(C)=O.CN(C)C=O.COc1ccccc1F.O.[Li]C(C)CC>>COc1cccc(C=O)c1F",
        "output": "239"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1ccccc1C1(C(C)C)C(=O)N(C)c2ccccc21.ClCCl>>CC(C)C1(c2ccccc2O)C(=O)N(C)c2ccccc21",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.Cc1noc(NC(=O)OCC(Cl)(Cl)Cl)c1C.O.c1ccc(-c2csc(N3CCNCC3)n2)cc1>>Cc1noc(NC(=O)N2CCN(c3nc(-c4ccccc4)cs3)CC2)c1C",
        "output": "980"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(N)cc1C#Cc1cnc(NCCCN2CCOCC2)nc1.O=C(O)c1cccc(C(F)(F)F)c1>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C#Cc1cnc(NCCCN2CCOCC2)nc1",
        "output": "50"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1nc(N(C)c2ccc(N)cc2)c2ccccc2n1.ClCCl>>Cc1nc(N(C)c2ccc(NS(C)(=O)=O)cc2)c2ccccc2n1",
        "output": "194"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc2nc(Cl)nc(N)c2cc1OC.Nc1ccc(OCc2ccccc2)cc1>>COc1cc2nc(Nc3ccc(OCc4ccccc4)cc3)nc(N)c2cc1OC",
        "output": "907"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC1NCC(CC(F)(F)F)Oc2nc(Cl)ccc21.CO.[Na+]>>CC1c2ccc(Cl)nc2OC(CC(F)(F)F)CN1C",
        "output": "217"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(S(=O)(=O)Cl)cc1C(=O)O.Cc1ccc(S(=O)(=O)CCO)cc1.ClCCl.O=S(Cl)Cl>>COc1ccc(S(=O)(=O)Cl)cc1C(=O)OCCS(=O)(=O)c1ccc(C)cc1",
        "output": "33"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CC1CCCCC1)C(=O)NCCN1CCCCC1.CCOC(C)=O.CCOC(C)=O.Cl>>N[C@@H](CC1CCCCC1)C(=O)NCCN1CCCCC1",
        "output": "431"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1ccc(C(C)C)cc1N.F[P-](F)(F)(F)(F)F.O=C(O)Cn1c(Cc2c(Cl)cccc2Cl)nc2ccccc21>>Cc1ccc(C(C)C)cc1NC(=O)Cn1c(Cc2c(Cl)cccc2Cl)nc2ccccc21",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](O)C1.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CC[C@H](OS(=O)(=O)c2ccccc2[N+](=O)[O-])C1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.CC(C)OC1CC2CC1CC2CCC=O.O=CCCC12CCC(CC1)C2.[BH4-].[Na+]>>CC(C)OC1CC2CC1CC2CCCO",
        "output": "223"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Cl.Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1.O.O=N[O-].[I-].[K+].[Na+]>>OC(c1ccc(I)cc1)(C(F)(F)F)C(F)(F)F",
        "output": "200"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCOC(C)=O.Nc1cnc2ccccc2c1.O=S(=O)(Cl)c1ccccc1.c1ccncc1>>O=S(=O)(Nc1cnc2ccccc2c1)c1ccccc1",
        "output": "554"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrP(Br)Br.ClC(Cl)(Cl)Cl.O=C([O-])[O-].OCCc1ccc(F)cc1.[Na+].[Na+]>>Fc1ccc(CCBr)cc1",
        "output": "301"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)c1cc(C)ccc1Nc1cnc(-c2cc(OC)ccc2F)c(C)c1.CO.N.O.[Na+].[OH-]>>COc1ccc(F)c(-c2ncc(Nc3ccc(C)cc3C(=O)O)cc2C)c1",
        "output": "5"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)NC1CCNC1.CS(C)=O.O=C(NCC1CCC(F)(F)CC1)c1c(Cl)ccc2nc(Cl)ccc12>>CC(=O)NC1CCN(c2ccc3c(C(=O)NCC4CCC(F)(F)CC4)c(Cl)ccc3n2)C1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCOCCOCCBr.COC(=O)c1ccc(O)c(F)c1.O=C([O-])[O-].[K+].[K+]>>CCOCCOCCOc1ccc(C(=O)OC)cc1F",
        "output": "385"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCSc1ccc(O)cc1.CN(C(=O)Cl)c1ccccc1>>CCCCCCCSc1ccc(OC(=O)N(C)c2ccccc2)cc1",
        "output": "425"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1ccc(C2CC2C(=O)O)cc1.CCN(CC)CC.CN(C)C=O.Cc1cccnc1C(=O)CN.Cl.Cl.ClCCl.O=C(Cl)C(=O)Cl>>Cc1cccnc1C(=O)CNC(=O)C1CC1c1ccc(C(C)(C)C)cc1",
        "output": "645"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)CN.Cc1ccccc1.O.O=[N+]([O-])c1ccc(Cl)c(Cl)c1Cl>>CC(C)CNc1c([N+](=O)[O-])ccc(Cl)c1Cl",
        "output": "304"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.CC(=O)O.COc1ccc(C(C)(C)C)cc1C(=O)C1CCCCC1.I>>CC(C)(C)c1ccc(O)c(C(=O)C2CCCCC2)c1",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CN(C)c1cccc2c(C(=O)CCCCCO[Si](C)(C)C(C)(C)C)c3c(cc12)CCC3.[F-]>>CN(C)c1cccc2c(C(=O)CCCCCO)c3c(cc12)CCC3",
        "output": "708"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(B(O)O)cc1.O=C1CCc2cc(Br)ccc2C1>>COc1ccc(-c2ccc3c(c2)CCC(=O)C3)cc1",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CCCCCCCCCCC.CCN(CC)CC.CCOC(C)=O.Cl[Pd]Cl.O=Cc1cccc(Br)c1.[Cu]I.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCCCCCCCCC#Cc1cccc(C=O)c1",
        "output": "659"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].Oc1c(F)cccc1Cl.[Cs+].[Cs+]>>Fc1cccc(Cl)c1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)Cl.Cc1ccc(N)cc1Cl.ClC(Cl)Cl.c1ccncc1>>COC(=O)Nc1ccc(C)c(Cl)c1",
        "output": "102"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)COc1cccc(F)c1.CN(C)C=O.[Li]C(C)CC>>CC(C)COc1cccc(F)c1C=O",
        "output": "239"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(O)Cn1ccc(N)n1.O=C(O)C(CC1CCCC1)n1ncc(Oc2cccc(F)c2)cc1=O>>CC(C)(O)Cn1ccc(NC(=O)C(CC2CCCC2)n2ncc(Oc3cccc(F)c3)cc2=O)n1",
        "output": "795"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "N#CC1CN(S(N)(=O)=O)C1.NS(=O)(=O)N1CCC1.O=C(O)c1cc(C2CC2)c(OCC23CC4CC(C2)CC(OC(=O)C(F)(F)F)(C4)C3)cc1F.O=C(O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F>>O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC23CC4CC(C2)CC(OC(=O)C(F)(F)F)(C4)C3)cc1F",
        "output": "886"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCn1ncc2c(NC3CCOCC3)c(-c3nc(CC4CCNCC4)no3)cnc21.CS(=O)(=O)Cl.Cl.ClC(Cl)Cl.c1ccncc1>>CCn1ncc2c(NC3CCOCC3)c(-c3nc(CC4CCN(S(C)(=O)=O)CC4)no3)cnc21",
        "output": "584"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCOn1cc(C(=O)CCl)cc1C(=O)c1ccc(Cl)cc1.CCNCC>>CCCOn1cc(C(=O)CN(CC)CC)cc1C(=O)c1ccc(Cl)cc1",
        "output": "414"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1cccc(NC(=O)COc2ccc(C(C)C)c(C)c2)c1.[I-].[Li+].c1ccncc1>>Cc1cc(OCC(=O)Nc2cccc(C(=O)O)c2)ccc1C(C)C",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(Cc1nc2ccccc2n1CC1CNC1)C1CCCc2cccnc21.CN(Cc1nc2ccccc2n1Cc1ccc(CN(Cc2ccccn2)C(=O)OC(C)(C)C)cc1)C1CCCc2cccnc21>>CN(Cc1nc2ccccc2n1Cc1ccc(CNCc2ccccn2)cc1)C1CCCc2cccnc21",
        "output": "887"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COCn1ccc2ncnc(Oc3ccc(N)cc3F)c21.O=C(Cc1ccccc1)N=C=S>>COCn1ccc2ncnc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c21",
        "output": "961"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.CN1CCOCC1.Cc1cc(Br)cc2[nH]c(-c3c(Cl)cc[nH]c3=O)nc12.N[C@H](CO)Cc1ccccc1>>Cc1cc(Br)cc2[nH]c(-c3c(N[C@H](CO)Cc4ccccc4)cc[nH]c3=O)nc12",
        "output": "78"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCN1.CCC(C)(C)O.CS(=O)(=O)c1nc(Nc2ccc(C(F)(F)F)cc2)c2nc(Cc3c(Cl)cccc3Cl)sc2n1>>FC(F)(F)c1ccc(Nc2nc(N3CCOCC3)nc3sc(Cc4c(Cl)cccc4Cl)nc23)cc1",
        "output": "679"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)c1cccc(C(=O)N[C@@H](C(=O)N2CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C2)C(C)C)c1.COC(OC)N(C)C>>CC(C)[C@@H](NC(=O)c1cccc(C(=O)/C=C/N(C)C)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1",
        "output": "898"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1ccc(O)cc1.CCN(CC)CC.CN=C=O.Cc1ccccc1>>CNC(=O)Oc1ccc(C(C)=O)cc1",
        "output": "104"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)c1ccc(-c2ccc(OCc3ccccc3)c(C=O)c2)cc1.O=C1CSC(=S)N1>>CN(C)c1ccc(-c2ccc(OCc3ccccc3)c(C=C3SC(=S)NC3=O)c2)cc1",
        "output": "314"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.COC(=O)c1cc(C(C)=O)ccc1OCCCBr.O.[I-].[N-]=[N+]=[N-].[Na+]>>COC(=O)c1cc(C(C)=O)ccc1OCCCN=[N+]=[N-]",
        "output": "622"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COC(=O)c1ccc2c(c1)ncn2-c1ccc(F)cc1.[Na+].[OH-]>>O=C(O)c1ccc2c(c1)ncn2-c1ccc(F)cc1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cl.NCCc1ccc(O)c(O)c1.O.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)NCCc1ccc(O)c(O)c1",
        "output": "631"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(N)c1ccc(C(C)(C)C#N)cc1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)c1ccncc1.Cl.F[P-](F)(F)(F)(F)F.O=C(O)Cn1cnc2ccc(F)c(F)c21>>CC(NC(=O)Cn1cnc2ccc(F)c(F)c21)c1ccc(C(C)(C)C#N)cc1",
        "output": "599"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.Cl.Cl.NS(=O)(=O)c1ccccc1S(N)(=O)=O.O.O=C(O)c1ccc(Br)c(OCCOCC(F)(F)F)c1>>NS(=O)(=O)c1ccccc1S(=O)(=O)NC(=O)c1ccc(Br)c(OCCOCC(F)(F)F)c1",
        "output": "579"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C(=O)[O-])c1nc(N2CCOCC2)cc(=O)[nH]1.COc1cc(N)ccc1F.[Na+]>>COc1cc(NC(=O)C(C)c2nc(N3CCOCC3)cc(=O)[nH]2)ccc1F",
        "output": "891"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)OCc1cc(O)ccc1S(=O)(=O)Nc1ccc2c(c1)B(O)OC2.Cl>>O=S(=O)(Nc1ccc2c(c1)B(O)OC2)c1ccc(O)cc1CO",
        "output": "497"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(N)CN.CCN(C(C)C)C(C)C.CN(C)C(=O)c1ccc(N(C)C(=O)c2cc3c(s2)-c2ccc(C(=O)O)cc2OCC3)c(Cl)c1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F>>CN(C)C(=O)c1ccc(N(C)C(=O)c2cc3c(s2)-c2ccc(C(=O)NCC(C)(C)N)cc2OCC3)c(Cl)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CCBr.C1CCOC1.Cc1ccccc1C.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.OCc1cccc(O)c1.[Na+].[OH-]>>C#CCOc1cccc(CO)c1",
        "output": "154"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cc2c([nH]1)C[C@@H]1C[C@H]21.[Li+].[OH-]>>O=C(O)c1cc2c([nH]1)C[C@@H]1C[C@H]21",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)N1CCNCC1.CCN=C=NCCCN(C)C.CN(C)C=O.O=C(O)/C=C/c1ccc(Cl)c([N+](=O)[O-])c1>>CC(=O)N1CCN(C(=O)/C=C/c2ccc(Cl)c([N+](=O)[O-])c2)CC1",
        "output": "811"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.NCc1c(F)cccc1F.Nc1ncccc1C(=O)O.O>>Nc1ncccc1C(=O)NCc1c(F)cccc1F",
        "output": "790"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Cc1cc([N+](=O)[O-])c(OC(C)C)cc1N1CCN(C)CC1.O=C[O-].[NH4+].[Pd]>>Cc1cc(N)c(OC(C)C)cc1N1CCN(C)CC1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)C(C)(C)CN1CCOC(c2ccc(OCc3c(Cl)cccc3Cl)cc2)C1.Cl.O.[Li+].[OH-]>>CC(C)(CN1CCOC(c2ccc(OCc3c(Cl)cccc3Cl)cc2)C1)C(=O)O",
        "output": "361"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1cc(-c2ccncc2)cc2nc(-c3ccccc3)nn12.O=C(Cl)Cc1ccccc1>>O=C(Cc1ccccc1)Nc1cc(-c2ccncc2)cc2nc(-c3ccccc3)nn12",
        "output": "527"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)C(c1ccccc1)N1CCN(C(C)=O)CC1.O.[Li+].[OH-]>>CC(=O)N1CCN(C(C(=O)O)c2ccccc2)CC1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Nc1cccc(CSc2ccc(Cl)cc2NS(=O)(=O)c2cc3ccccc3o2)c1.ClCCl.O=C(OO)c1cccc(Cl)c1>>CC(=O)Nc1cccc(CS(=O)c2ccc(Cl)cc2NS(=O)(=O)c2cc3ccccc3o2)c1",
        "output": "500"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)N.CCO.C[Si](C)(C)CC[Si](C)(C)CCCOCC1CO1>>CC(C)NCC(O)COCCC[Si](C)(C)CC[Si](C)(C)C",
        "output": "16"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(S(=O)(=O)N2CC=CCC(NC(=O)OCc3ccccc3)C2C(=O)OC(C)(C)C)cc1.COc1ccc(S(=O)(=O)N2CC=CCC(NS(=O)(=O)Cc3ccccc3)C2C(=O)OC(C)(C)C)cc1>>COc1ccc(S(=O)(=O)N2CC=CCC(NS(=O)(=O)Cc3ccccc3)C2C(=O)O)cc1",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NC[C@H]1CC[C@@H](C(=O)CCc2ccccc2)CC1.CCO.[BH4-].[Na+]>>CC(C)(C)OC(=O)NC[C@H]1CC[C@@H](C(O)CCc2ccccc2)CC1",
        "output": "91"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)C1CC1c1nc2c(N3CCN(CC(=O)Nc4nccs4)CC3)c(Br)cnc2[nH]1.[NH4+].[OH-]>>NC(=O)C1CC1c1nc2c(N3CCN(CC(=O)Nc4nccs4)CC3)c(Br)cnc2[nH]1",
        "output": "163"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CNC.ClCCCl.O=C(COc1ccc(Cl)cc1Cl)Nc1cc(C(=O)O)ccn1.On1nnc2ccccc21>>CN(C)C(=O)c1ccnc(NC(=O)COc2ccc(Cl)cc2Cl)c1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COc1cc(N2CCC(Oc3ccc(C4CC4)cc3)C2=O)ccc1O.O=C([O-])[O-].OCCBr.[K+].[K+]>>COc1cc(N2CCC(Oc3ccc(C4CC4)cc3)C2=O)ccc1OCCO",
        "output": "75"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.COc1ccc(C(=O)c2ccc(N)cc2)cc1.CS(=O)(=O)Cl.ClCCl.O.c1ccncc1>>COc1ccc(C(=O)c2ccc(NS(C)(=O)=O)cc2)cc1",
        "output": "194"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CNCCN1.CCOC(C)=O.COC(=O)c1ccc(F)cc1Oc1cnc(N)c(Cl)c1.CS(C)=O>>COC(=O)c1ccc(N2CCNCC2)cc1Oc1cnc(N)c(Cl)c1",
        "output": "773"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(=O)N1CCC2(CCNC2)C1.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.CN(Cc1ccc(-c2nnc(-c3nc(Br)cnc3N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)o2)cc1)C(=O)OC(C)(C)C>>CCC(=O)N1CCC2(CCN(c3cnc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(-c4nnc(-c5ccc(CN(C)C(=O)OC(C)(C)C)cc5)o4)n3)C2)C1",
        "output": "211"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc2c(c1)CCn1c-2cc(Cl)nc1=O.Nc1ccc2cn[nH]c2c1>>COc1ccc2c(c1)CCn1c-2cc(Nc2ccc3cn[nH]c3c2)nc1=O",
        "output": "161"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCN(CC)CC.Cc1c(OC2CCCC2)cccc1S(=O)(=O)Cl.Cc1nccc(CN)c1C>>Cc1nccc(CNS(=O)(=O)c2cccc(OC3CCCC3)c2C)c1C",
        "output": "43"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc([N+](=O)[O-])cn1>>O=C(c1ccc([N+](=O)[O-])cn1)N1CCCC1",
        "output": "605"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)C1(NC(=O)c2ccc(OCC)cc2)CC1.CO.O.[Li+].[OH-]>>CCOc1ccc(C(=O)NC2(C(=O)O)CC2)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CCOC(C)=O.COC/C=C/c1cccc(N)c1C#N.NS(=O)(=O)Cl>>COC/C=C/c1cccc(NS(N)(=O)=O)c1C#N",
        "output": "395"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(C)=O.Cc1c2cc(-n3ccc(O)cc3=O)ccc2nn1C.OCc1cccc(Cl)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1c2cc(-n3ccc(OCc4cccc(Cl)c4)cc3=O)ccc2nn1C",
        "output": "347"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CCN(C(=O)c2ncn([C@@H]3CCNC3)c2-c2ccccc2)[C@H](Cc2ccccc2)C1.CCN(CC)CC.O>>CC(=O)N1CC[C@@H](n2cnc(C(=O)N3CCN(C(=O)OC(C)(C)C)C[C@H]3Cc3ccccc3)c2-c2ccccc2)C1",
        "output": "369"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCOCCOCCOCCO1.Cc1c(C=O)c[nH]c1-c1ccccc1.O=S(=O)(Cl)c1cccc2c1OCCO2.[H-].[Na+]>>Cc1c(C=O)cn(S(=O)(=O)c2cccc3c2OCCO3)c1-c1ccccc1",
        "output": "648"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CCC(=O)OC1CCCCC1)CSc1ccc(Cc2ccccc2)cc1.ClCCl.O=C(O)C(F)(F)F>>N[C@@H](CCC(=O)OC1CCCCC1)CSc1ccc(Cc2ccccc2)cc1",
        "output": "538"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.C[O-].Cc1nc(Cl)c([N+](=O)[O-])c(Cl)n1.O.[Na+]>>COc1nc(C)nc(Cl)c1[N+](=O)[O-]",
        "output": "461"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N(C(=O)OC(C)(C)C)c2ccc(C(=O)O)c(N)c2)CC1.CCOC(=O)c1cc(C(F)(F)F)c(C=O)c(Cl)c1N.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1CCC(N(C(=O)OC(C)(C)C)c2cc(N)c(C(=O)O)cc2Br)CC1",
        "output": "4"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(Cc1ccccc1Nc1cccn2nc(Cl)nc12)S(C)(=O)=O.CN1CCN(c2cccc(N)c2)CC1.c1ccc(P(C2CCCCC2)C2CCCCC2)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c1>>CN1CCN(c2cccc(Nc3nc4c(Nc5ccccc5CN(C)S(C)(=O)=O)cccn4n3)c2)CC1",
        "output": "990"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc(C=C2CCN(C(=O)c3ccc(Cl)cc3)CC2)c(F)c1.O.[K+].[OH-]>>O=C(O)c1ccc(C=C2CCN(C(=O)c3ccc(Cl)cc3)CC2)c(F)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCCN(CC(O)CC#N)CC1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O>>CC(C)(C)OC(=O)N1CCCN(CC(CC#N)OS(C)(=O)=O)CC1",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Cc1ccccc1.Cl.N.O=C(O)C1(c2ccccc2)CC1.O=S(Cl)Cl>>NC(=O)C1(c2ccccc2)CC1",
        "output": "313"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1cnc2sc3c(n12)CCCC3.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1cnc2sc3c(n12)CCCC3",
        "output": "286"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COC(=O)c1ccc(CC(=O)O)c(F)c1.ClCCl.O=C(Cl)C(=O)Cl>>COC(=O)c1ccc(CC(=O)Cl)c(F)c1",
        "output": "56"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(Br)ccc1N.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>COc1cc(Br)ccc1NC(=O)C(F)(F)F",
        "output": "106"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)COc1ccc(S(C)(=O)=O)cc1.N#Cc1ccc(NN)cc1>>CC(COc1ccc(S(C)(=O)=O)cc1)=NNc1ccc(C#N)cc1",
        "output": "285"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCOc1ccc(F)c(B(O)O)c1.Nc1cc(F)c(Br)nc1C(=O)O>>CCCOc1ccc(F)c(-c2nc(C(=O)O)c(N)cc2F)c1",
        "output": "869"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CC(C(=O)OC(C)(C)C)C(O)CCOCc1ccccc1)C(=O)OC(C)(C)C.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)N[C@@H](CC(C(=O)OC(C)(C)C)C(CCOCc1ccccc1)OS(C)(=O)=O)C(=O)OC(C)(C)C",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCO.Clc1cccnc1Cl.NN.O.O=C([O-])[O-].[K+].[K+]>>NNc1ncccc1Cl",
        "output": "417"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(=O)Cl.CCN(C(C)C)C(C)C.ClCCl.O=C(Cn1ccn2c(=O)c(OCc3ccccc3)c(-c3ncc(Cc4ccc(F)cc4)s3)nc12)N1CCNCC1.O=C([O-])O.[Na+]>>CC(C)(C)C(=O)N1CCN(C(=O)Cn2ccn3c(=O)c(OCc4ccccc4)c(-c4ncc(Cc5ccc(F)cc5)s4)nc23)CC1",
        "output": "125"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(-c3cnc4[nH]cc(-c5cnn(Cc6cccnc6)c5)c4c3)cc2)CC1.CCOCC.CO.Cl>>c1cncc(Cn2cc(-c3c[nH]c4ncc(-c5ccc(N6CCNCC6)cc5)cc34)cn2)c1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.Nc1cc(Cl)c([N+](=O)[O-])cc1Cl.O=C([O-])[O-].Oc1ccccc1.[K+].[K+]>>Nc1cc(Oc2ccccc2)c([N+](=O)[O-])cc1Cl",
        "output": "299"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)CBr.CN(C)C=O.Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(O)c2F)c1C.O.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)cc(C)c2C)c1F",
        "output": "123"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCc1cc(-c2cncc(C(=O)O)c2)c(C)[nH]c1=O.O=C(C1CC1)N1CCNCC1>>CCc1cc(-c2cncc(C(=O)N3CCN(C(=O)C4CC4)CC3)c2)c(C)[nH]c1=O",
        "output": "256"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CON=C(CN1C(=O)c2ccccc2C1=O)c1ncc(OCC(F)(F)F)cc1Cl.NN.O.O>>CON=C(CN)c1ncc(OCC(F)(F)F)cc1Cl",
        "output": "242"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.OCCc1ccsc1.Oc1cccnc1I.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Ic1ncccc1OCCc1ccsc1",
        "output": "547"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrBr.CC(=O)O.CCOC(=O)C1CNc2cc(Cl)ccc2O1>>CCOC(=O)C1CNc2cc(Cl)c(Br)cc2O1",
        "output": "98"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.O.O=[N+]([O-])c1ccc(Br)cc1OCc1ccccc1.[Cl-].[Fe].[NH4+]>>Nc1ccc(Br)cc1OCc1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)O.CN1CCOCC1.NCCc1ccc2ccccc2n1>>CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccc2ccccc2n1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.Cl.ClCCl.NCCC(N)=O.O=C(c1ccc(F)c([N+](=O)[O-])c1)C1CCCCC1>>NC(=O)CCNc1ccc(C(=O)C2CCCCC2)cc1[N+](=O)[O-]",
        "output": "572"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.Cn1cccc(-c2ccc(OCc3ccccc3)cc2)c1=O.[Pd]>>Cn1cccc(-c2ccc(O)cc2)c1=O",
        "output": "23"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)Cl.Cc1nn(-c2c(N)cccc2F)cc1C=O.ClCCl.O.c1ccncc1.c1cn[nH]c1>>COC(=O)Nc1cccc(F)c1-n1cc(C=O)c(C)n1",
        "output": "102"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.N#Cc1cc(S(=O)(=O)Cl)ccc1F.Nc1nccs1.c1ccncc1>>N#Cc1cc(S(=O)(=O)Nc2nccs2)ccc1F",
        "output": "637"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1cccc(OCCCNC(=O)OC(C)(C)C)c1.O.[Li+].[OH-]>>CC(C)(C)OC(=O)NCCCOc1cccc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.Nc1cc(F)c(F)cc1Cl.O.S=C(Cl)Cl.[Na+].[OH-]>>Fc1cc(Cl)c(N=C=S)cc1F",
        "output": "114"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)C1CC1Cc1ccc2[nH]cc(C#N)c2c1.CO.O.[Li+].[OH-]>>N#Cc1c[nH]c2ccc(CC3CC3C(=O)O)cc12",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1cc(Cc2ccc3c(c2)C[C@@H](NS(=O)(=O)C(F)(F)F)C3)cc(C(F)(F)F)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>O=S(=O)(N[C@H]1Cc2ccc(Cc3cc(CO)cc(C(F)(F)F)c3)cc2C1)C(F)(F)F",
        "output": "444"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.O=[N+]([O-])c1ccc(C(F)(F)F)cc1.O=[Pt].[H][H]>>Nc1ccc(C(F)(F)F)cc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[C@@H](N)CO.Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(C(=O)O)cn1>>Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(C(=O)N[C@H](C)CO)cn1",
        "output": "674"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CN(C(=O)C1CCSCC1)c1ccc(OC)cc1.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.[Na+]>>CCOC(=O)CN(C(=O)C1CCS(=O)CC1)c1ccc(OC)cc1",
        "output": "13"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOCC.CCc1sc(C(=O)CCc2cc(C)c(OCCO)c(C)c2)c2c1CC(C)(C)CC2.CS(=O)(=O)Cl>>CCc1sc(C(=O)CCc2cc(C)c(OCCOS(C)(=O)=O)c(C)c2)c2c1CC(C)(C)CC2",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N[C@H](CCCc1ccccc1)[C@H](O)C(=O)O.Cl>>N[C@H](CCCc1ccccc1)[C@H](O)C(=O)O",
        "output": "538"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCC.CO.COC(=O)c1cc(N(C)Cc2ccccc2)ccn1.Cl.O.[Li+].[OH-]>>CN(Cc1ccccc1)c1ccnc(C(=O)O)c1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.ClCc1ccc(Cl)c(Cl)c1>>CC(C)(C)OC(=O)N1CCN(Cc2ccc(Cl)c(Cl)c2)CC1",
        "output": "156"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.Cc1cc(C(=O)NC2CCC3(CC2)COC3)cc2nc(C(F)(F)F)c(CC3CCC(F)(F)CC3)n12.Cc1cc(C(=O)O)cc2nc(C(C)(F)F)c(Cc3ccc(Cl)cc3)n12.Cl.NC1CCOCC1>>Cc1cc(C(=O)NC2CCOCC2)cc2nc(C(C)(F)F)c(Cc3ccc(Cl)cc3)n12",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "NNc1c(F)c(F)c(F)c(F)c1F.O=Cc1ccc(O)cc1O>>Oc1ccc(C=NNc2c(F)c(F)c(F)c(F)c2F)c(O)c1",
        "output": "167"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cccc(N)c1.Nc1ncccc1-c1cc2cc(C(=O)O)ccc2s1>>Cc1cccc(NC(=O)c2ccc3sc(-c4cccnc4N)cc3c2)c1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)C(C)N1CCCCCCC1=O.O.[Na+].[OH-]>>CC(C(=O)O)N1CCCCCCC1=O",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1Br.OB(O)c1cncc(F)c1>>CN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cncc(F)c1",
        "output": "883"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Clc1ccc(N2CCC3(CC2)OCCO3)cc1-c1nc2ccccc2[nH]1.O.O=C([O-])[O-].O=S(=O)(O)O.[Na+].[Na+]>>O=C1CCN(c2ccc(Cl)c(-c3nc4ccccc4[nH]3)c2)CC1",
        "output": "251"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)O.CC1(C)Cn2ncc(N)c2CO1.CNc1nc(Cl)ncc1C(F)(F)F>>CNc1nc(Nc2cnn3c2COC(C)(C)C3)ncc1C(F)(F)F",
        "output": "992"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)CCN.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CC(F)(F)C(=O)N2C.F[P-](F)(F)(F)(F)F>>COc1cc(C(=O)NCCN(C)C)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CI.CN(C)C=O.O=C(O)c1cnccc1CC(=O)N1CCC([C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c32)CC1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cnccc1CC(=O)N1CCC([C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c32)CC1",
        "output": "415"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.CCOC(C)=O.COc1ccc(Oc2c(C)cc([N+](=O)[O-])cc2Cl)cc1C=O.ClCCl.O>>Cc1cc([N+](=O)[O-])cc(Cl)c1Oc1ccc(O)c(C=O)c1",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.O=C(O)C1(c2ccc(Cl)cc2)CC1.O[C@H]1CCNC1>>O=C(N1CC[C@H](O)C1)C1(c2ccc(Cl)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.CCCCO.CN1CC(CCCl)OC1=O.FC(F)(F)c1ccc(N2CCNCC2)cc1.O=C([O-])[O-].[I-].[K+].[Na+].[Na+]>>CN1CC(CCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)OC1=O",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.NCCNc1nc(Cl)nc2c1ncn2C1CCCC1.O>>Cc1ccc(S(=O)(=O)NCCNc2nc(Cl)nc3c2ncn3C2CCCC2)cc1",
        "output": "43"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=[N+]([O-])c1ccc(N2CC3CCC3C2)nc1.[Pd]>>Nc1ccc(N2CC3CCC3C2)nc1",
        "output": "269"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)CC(O)CO.CO.C[O-].Cc1ccc(Br)nc1.Cl.O.[Cu]Br.[Na+]>>COc1ccc(C)cn1",
        "output": "551"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClCCl.II.OCCc1cccc(-c2ccccc2)c1.c1c[nH]cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>ICCc1cccc(-c2ccccc2)c1",
        "output": "670"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCc1c(C)c2ccc(O)cc2[nH]c1=O.CCOC(C)O.ClCCCN1CCN(Cc2ccc(Cl)cc2)CC1>>CCCCc1c(C)c2ccc(OCCCN3CCN(Cc4ccc(Cl)cc4)CC3)cc2[nH]c1=O",
        "output": "74"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC(O)CO2)C1.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OC2COC3(CCN(C(=O)OC(C)(C)C)C3)C2)cc1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COc1ccc(C(=O)Cc2cccc(Cl)n2)cc1.Cl.NO.[Na+].[OH-]>>COc1ccc(C(Cc2cccc(Cl)n2)=NO)cc1",
        "output": "212"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cl[Sn]Cl.N#Cc1cnc2ccc([N+](=O)[O-])cc2c1Nc1cccc(C(F)(F)F)c1.O.O.O=C([O-])O.[Na+]>>N#Cc1cnc2ccc(N)cc2c1Nc1cccc(C(F)(F)F)c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CCCN.CN(C)C=O.Clc1c2ccccc2nc2ccccc12>>CCN(CC)CCCNc1c2ccccc2nc2ccccc12",
        "output": "78"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CCc1ccc(Oc2cc(C)cc(O)c2)cc1C.CCOCC.CS(C)=O.Cl.Fc1ccc(C(F)(F)F)cc1Br.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CCc1ccc(Oc2cc(C)cc(Oc3ccc(C(F)(F)F)cc3Br)c2)cc1C",
        "output": "564"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(N)cn1.ClCCl.O=C(Cl)C(Cl)Cl.c1ccncc1>>COc1ccc(NC(=O)C(Cl)Cl)cn1",
        "output": "422"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.CS(=O)(=O)c1ncc(C(N)=O)c(NC23CC(C2)C3)n1.CS(=O)c1ncc(C(N)=O)c(NC23CC(C2)C3)n1.Cl.NC1CCOCC1>>NC(=O)c1cnc(NC2CCOCC2)nc1NC12CC(C1)C2",
        "output": "629"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1cccnc1.CC(C)(C)[O-].Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[K+].[Pd].[Pd].c1ccc(CN2CCCC23CCNC3)cc1.c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>c1ccc(CN2CCCC23CCN(c2cccnc2)C3)cc1",
        "output": "597"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#Cc1ccc(C=O)cc1.CN1CCCNCC1.NC(=O)c1cc(F)cc2cc(-c3ccc(CN4CCCC4)cc3)oc12>>C#Cc1ccc(CN2CCCN(C)CC2)cc1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.N.O.O=C(O)c1cc(Br)cc(C(F)(F)F)c1.O=C1CCC(=O)N1O>>NC(=O)c1cc(Br)cc(C(F)(F)F)c1",
        "output": "358"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCn1cc(C2CCN(C(=O)OC(C)(C)C)CC2)c2cc(NC(=O)c3cc(C#N)ccn3)ccc21.Cl.ClCCl.O=C([O-])O.[Na+]>>CCn1cc(C2CCNCC2)c2cc(NC(=O)c3cc(C#N)ccn3)ccc21",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1nn(C2CCCC2)c2cc(Br)ccc12.OB(O)c1ccccc1>>CCc1nn(C2CCCC2)c2cc(-c3ccccc3)ccc12",
        "output": "909"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)S(=O)(=O)NCC(C)(F)c1ccc(-c2ccc(C(=O)O)cc2)cc1.CN(C)C=O.CNC.ClCCl.O.O=C(Cl)C(=O)Cl>>CC(C)S(=O)(=O)NCC(C)(F)c1ccc(-c2ccc(C(=O)N(C)C)cc2)cc1",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1cc(CSc2ccccc2)cnc1C1=NC(C)(C(C)C)C(=O)N1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.O=S([O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+]>>COC(=O)c1cc(CS(=O)c2ccccc2)cnc1C1=NC(C)(C(C)C)C(=O)N1",
        "output": "500"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cnn(Cc2ccccc2)c(=O)c1.CO.[BH4-].[Ca+2].[Cl-].[Cl-].[Na+]>>O=c1cc(CO)cnn1Cc1ccccc1",
        "output": "383"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1cnc(Cl)nc1Cl.Cl.N#Cc1ccc(N2CCC(N)CC2)nc1>>Cc1cnc(Cl)nc1NC1CCN(c2ccc(C#N)cn2)CC1",
        "output": "166"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O.O=C=Nc1cccc2ccccc12.OCCO>>O=C(Nc1cccc2ccccc12)OCCO",
        "output": "34"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)/N=N/C(=O)OCC.CCOC(=O)C(C)(C)Oc1cccc(O)c1.CCc1ccc(OC(C)CCO)c(C(=O)c2ccccc2)c1.Cc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)C(C)(C)Oc1cccc(OCCC(C)Oc2ccc(CC)cc2C(=O)c2ccccc2)c1",
        "output": "478"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.ClCCl.N[C@H](CC1CCCCC1)CN1CCN(c2ncccn2)CC1.O=C(Cl)C1CCC1>>O=C(N[C@H](CC1CCCCC1)CN1CCN(c2ncccn2)CC1)C1CCC1",
        "output": "45"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C(=O)OC(C)(C)C)c1cc2cc(Br)ccc2cn1.CS(C)=O.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CN(C(=O)OC(C)(C)C)c1cc2cc(B3OC(C)(C)C(C)(C)O3)ccc2cn1",
        "output": "942"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)Cc2cccc(CN3CCC4(CC3)CNC4)c2O1.Cl.O=C(O)Cc1ccncc1>>CC1(C)Cc2cccc(CN3CCC4(CC3)CN(C(=O)Cc3ccncc3)C4)c2O1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.O=C(O)CC(c1ccccc1)c1c[nH]c2cccnc12.O=C([O-])O.[Na+]>>CNC(=O)CC(c1ccccc1)c1c[nH]c2cccnc12",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCSc1ccccc1-c1nc2cc(C(F)(F)F)ccc2c(=O)[nH]1.Cc1ccccc1.O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+]>>CCSc1ccccc1-c1nc(Cl)c2ccc(C(F)(F)F)cc2n1",
        "output": "14"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1c(Cl)ncc(C(=O)N2CCC(c3ccc(F)cc3)CC2)c1Cl.N#Cc1ccc(N)cc1>>Cc1c(Cl)ncc(C(=O)N2CCC(c3ccc(F)cc3)CC2)c1Nc1ccc(C#N)cc1",
        "output": "957"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)NCCNc1nc(-c2ccc(Cl)cc2)nc(NCCN)c1C.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCCC1=O.F[P-](F)(F)(F)(F)F.O=C(O)c1cc2ccccc2cn1>>CC(=O)NCCNc1nc(-c2ccc(Cl)cc2)nc(NCCNC(=O)c2cc3ccccc3cn2)c1C",
        "output": "137"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)Cl.Cl.ClCCl.O=[N+]([O-])c1ccc2c(c1)CCNCC2>>CCOC(=O)N1CCc2ccc([N+](=O)[O-])cc2CC1",
        "output": "219"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=Cc1n[nH]c2cccc([N+](=O)[O-])c12.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl>>C=Cc1nn(C(=O)OC(C)(C)C)c2cccc([N+](=O)[O-])c12",
        "output": "841"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.CO.COC(=O)C(CC1CCNCC1)NC(=O)CN(C)S(=O)(=O)c1ccc(C)cc1.Cl.Cl.O=C([O-])O.O=Cc1ccccc1.[BH3-]C#N.[Na+].[Na+]>>COC(=O)C(CC1CCN(Cc2ccccc2)CC1)NC(=O)CN(C)S(=O)(=O)c1ccc(C)cc1",
        "output": "567"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)C(O)(c1cccc(Br)c1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.Cc1ccc(B(O)O)cc1>>Cc1ccc(-c2cccc(C(O)(c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)C(C)C)c2)cc1",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(c1ccccc1)(c1ccccc1)C(O)C#N.CN(C)C=O.COc1cc(OC)nc(S(C)(=O)=O)n1.O=C([O-])[O-].[K+].[K+]>>CCC(c1ccccc1)(c1ccccc1)C(C#N)Oc1nc(OC)cc(OC)n1",
        "output": "667"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1ccc(C2(C#N)CCCCC2)cc1.ClCCl>>N#CC1(c2ccc(O)cc2)CCCCC1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1ccccc1.C1CC2(CCN1)OCCO2.CC(C)(C)[O-].COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1ccccc1.ClC(Cl)Cl.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>c1ccc(N2CCC3(CC2)OCCO3)cc1",
        "output": "294"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OCC(OC)OC)cc3)oc2c1.CCOC(C)=O.Cl>>CCC1CC(=O)NN=C1c1ccc2nc(-c3ccc(OCC=O)cc3)oc2c1",
        "output": "234"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COCCNc1cc(C)c(OC)c(C)c1CSc1ncc[nH]1.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.O=C([O-])[O-].[Na+].[Na+]>>COCCNc1cc(C)c(OC)c(C)c1CS(=O)c1ncc[nH]1",
        "output": "595"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1nc(C2CCOC2)n(C(C)C)c1C(N)c1ccc(Cl)cc1.Cl>>CC(C)n1c(C2CCOC2)nc(C(=O)O)c1C(N)c1ccc(Cl)cc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)C(C(=O)OCC)C(c1ccccc1)c1ccc(NC(=O)OC(C)(C)C)nc1.ClCCl.[K+].[OH-]>>CCOC(=O)C(C(=O)O)C(c1ccccc1)c1ccc(NC(=O)OC(C)(C)C)nc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccsc1NC(=O)OC(C)(C)C.O.[Li+].[OH-]>>CC(C)(C)OC(=O)Nc1sccc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.Nc1cccc(Br)c1.O=C1CCOCC1.[Na+]>>Brc1cccc(NC2CCOCC2)c1",
        "output": "469"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cccc(C(=O)C2CCN(C(=O)OC(C)(C)C)CC2)c1F.Cl.NO.O.c1ccncc1>>COc1cccc(C(=NO)C2CCN(C(=O)OC(C)(C)C)CC2)c1F",
        "output": "212"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(N)(=O)=O.NS(=O)(=O)C1CC1.O=C(O)c1cc(C2CC2)c(O[C@@H]2CCCN(Cc3ccc(Cl)c(Cl)c3)C2)cc1F.O=C(O)c1cc(C2CC2)c(O[C@@H]2CCCN(Cc3ccc(F)cc3)C2)cc1F>>O=C(NS(=O)(=O)C1CC1)c1cc(C2CC2)c(O[C@@H]2CCCN(Cc3ccc(F)cc3)C2)cc1F",
        "output": "580"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1cnc2ccccc2c1.Nc1cnc2ccccc2n1.O=C(O)C1CCN(c2cnc3ccccc3c2)CC1>>O=C(Nc1cnc2ccccc2n1)C1CCN(c2cnc3ccccc3c2)CC1",
        "output": "692"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCN(C(=O)c1ccc(N2CCN(CCCCC3(C(=O)NCC(F)(F)F)c4ccccc4-c4ccccc43)CC2)nc1)C1CCCCC1.CO.ClCCl.[Pd]>>CCCN(C(=O)c1ccc(N2CCN(CCCCC3(C(=O)NCC(F)(F)F)c4ccccc4-c4ccccc43)CC2)nc1)C1CCCCC1",
        "output": "116"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)CCOCCOCCOCCO.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCCOCCOCCOCCC(=O)OC(C)(C)C)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.ClC(Cl)Cl.NCC1CCOC1.O=C(O)c1cc(COCc2cccc(C(F)(F)F)c2)on1.On1nnc2ccccc21>>O=C(NCC1CCOC1)c1cc(COCc2cccc(C(F)(F)F)c2)on1",
        "output": "696"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=C(O)c1cccc(O)c1[N+](=O)[O-].O=S(Cl)Cl>>COC(=O)c1cccc(O)c1[N+](=O)[O-]",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CC(C)=O.CN(C)C=O.Cl.Cl.Nc1ncnc2c1c(-c1ccc(Cl)cc1)nn2C1CNC1.O.c1ccncc1>>CC(=O)N1CC(n2nc(-c3ccc(Cl)cc3)c3c(N)ncnc32)C1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)CN.CCN(C(C)C)C(C)C.CN(C)C=O.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)COc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3ccccc3n2)c1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CC(C)(C)CNC(=O)COc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3ccccc3n2)c1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)N(c1cccc(Br)c1)c1c(C#N)cnc2c(C)cc([N+](=O)[O-])cc12.ClC(Cl)(Cl)Cl.ClCCl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br.O=S([O-])O.[Na+]>>CC(=O)N(c1cccc(Br)c1)c1c(C#N)cnc2c(CBr)cc([N+](=O)[O-])cc12",
        "output": "625"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(CN)c1ncc[nH]1.NCCc1c[nH]cn1.Nc1nc(C(F)(F)F)c(Br)nc1C(=O)O>>CC(CNC(=O)c1nc(Br)c(C(F)(F)F)nc1N)c1ncc[nH]1",
        "output": "697"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1c(C(=O)O)cnn1-c1ccccc1.N[C@H]1CO[C@@H]2[C@@H](NC(=O)C3CC3)CO[C@H]12>>Cc1c(C(=O)N[C@H]2CO[C@@H]3[C@@H](NC(=O)C4CC4)CO[C@H]23)cnn1-c1ccccc1",
        "output": "621"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1sc2ncnc(Nc3ccc(F)cc3O)c2c1C.Cl.[Na+].[OH-]>>Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3O)c12",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)C1=CC(=O)C(C)(C2=CCCCC2)O1.O.[Li]O>>CC1(C2=CCCCC2)OC(C(=O)O)=CC1=O",
        "output": "58"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.OCCc1cccc(F)c1F>>Cc1ccc(S(=O)(=O)OCCc2cccc(F)c2F)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.O=C([O-])O.OC(CBr)c1cc(-c2ccccc2)on1.OC1CCNCC1.[Na+].c1ccccc1>>OC1CCN(CC(O)c2cc(-c3ccccc3)on2)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCCCCC.CCCCc1nc(C)n(-c2ncc(OC)cn2)c(=O)c1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1.COc1ccccc1.O.O=C(O)C(F)(F)F.[Na+].[OH-]>>CCCCc1nc(C)n(-c2ncc(OC)cn2)c(=O)c1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1",
        "output": "680"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCC1(N2CC3(CCN(S(=O)(=O)c4ccc(Br)cc4)CC3)OCC2=O)CC1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>O=C1COC2(CCN(S(=O)(=O)c3ccc(Br)cc3)CC2)CN1C1(CO)CC1",
        "output": "708"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C#N)c1cccc(Nc2cc(Cl)nnc2C(N)=O)n1.CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1N.CN1CCCC1=O>>CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1Nc1cc(Nc2cccc(C(C)(C)C#N)n2)c(C(N)=O)nn1",
        "output": "241"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C[C@]1(c2cc(N)ccc2F)N=C(N)OCC1(F)F.O=C(O)c1ccccn1>>C[C@]1(c2cc(NC(=O)c3ccccn3)ccc2F)N=C(N)OCC1(F)F",
        "output": "985"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.ClCCl.O=Cc1nc(Cl)cc2c1c(OCc1ccccc1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1.[BH4-].[Na+]>>OCc1nc(Cl)cc2c1c(OCc1ccccc1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "745"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.COC(=O)C(C)(C(=O)OC)C(Cc1ccccc1[N+](=O)[O-])c1ccc(OC)cc1.O=C(O)C(F)(F)F.[Pd]>>COC(=O)C(C)(C(=O)OC)C(Cc1ccccc1N)c1ccc(OC)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.Cc1c(S(N)(=O)=O)cc(-c2cc(C(C)(C)C)cc(C(C)(C)CN)c2)n1CC1CCCCC1.ClCCl>>CC(=O)NCC(C)(C)c1cc(-c2cc(S(N)(=O)=O)c(C)n2CC2CCCCC2)cc(C(C)(C)C)c1",
        "output": "339"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)CNc1c(CC)cccc1CC.NN.O>>CCc1cccc(CC)c1NCC(=O)NN",
        "output": "164"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.OCc1cnc(OCC(F)(F)F)c(Cl)c1.[Mn+4].[O-2].[O-2]>>O=Cc1cnc(OCC(F)(F)F)c(Cl)c1",
        "output": "520"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrBr.COc1ccc(C=O)cc1.ClCCCl>>COc1ccc(C=O)cc1Br",
        "output": "98"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(C)=O.O=[N+]([O-])c1ccc2c(ccn2Cc2cccnc2)c1.[Pd]>>Nc1ccc2c(ccn2Cc2cccnc2)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N(C)C.FC(F)(F)C1(c2cc(Cl)cc(Cl)c2)CC(c2cnc(Cl)c(Cl)c2)=NO1.N.O.O.[C-]#N.[C-]#N.[Pd].[Zn+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1ncc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1Cl",
        "output": "726"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1c(N[C@@H](c2nnc(-c3ccc(NC(=O)c4ccccc4)cc3)o2)[C@H](C)O[Si](C)(C)C(C)(C)C)ccc(C#N)c1Cl.[F-]>>Cc1c(N[C@@H](c2nnc(-c3ccc(NC(=O)c4ccccc4)cc3)o2)[C@H](C)O)ccc(C#N)c1Cl",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CNS(=O)(=O)c1ccc2c(c1)CC(=O)N2.O=Cc1[nH]c2c(c1CCCN1CCN(C(=O)CO)CC1)CCCC2>>CNS(=O)(=O)c1ccc2c(c1)/C(=C/c1[nH]c3c(c1CCCN1CCN(C(=O)CO)CC1)CCCC3)C(=O)N2",
        "output": "911"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(CN([C@@H](CC)c2ccccc2)S(=O)(=O)c2ccc(Cl)cc2)nc1.CO.[BH4-].[Na+]>>CC[C@@H](c1ccccc1)N(Cc1ccc(CO)cn1)S(=O)(=O)c1ccc(Cl)cc1",
        "output": "383"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl[Sn]Cl.O=[N+]([O-])c1cc(Br)ccc1Sc1ccccc1>>Nc1cc(Br)ccc1Sc1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=O.CC(=O)O.CO.C[C@@H]1C(=O)NN=C2COc3cc(-c4c(F)cccc4F)c([C@@H]4CCNC[C@@H]4C)cc3N21.O=C([O-])O.[BH3-]C#N.[Na+].[Na+]>>C[C@@H]1C(=O)NN=C2COc3cc(-c4c(F)cccc4F)c([C@@H]4CCN(C)C[C@@H]4C)cc3N21",
        "output": "217"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCCOCCBr.O=c1[nH]c2ccccc2n1C1CCNC1>>CCOCCOCCN1CCC(n2c(=O)[nH]c3ccccc32)C1",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=C(CCC(=O)OC)c1ccc(Cl)cc1.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>C=C(CCCO)c1ccc(Cl)cc1",
        "output": "343"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=Cc1ccc(Br)cc1F.CCOC(C)=O.[Pd]>>CCc1ccc(Br)cc1F",
        "output": "555"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)c1ccc(I)cc1N.COC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12.ClCCl.NCCN(CCN)CCN.O=S(=O)(Cl)c1cccc2nsnc12.c1ccncc1>>O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C=O)cc1.Nc1ccc2nc[nH]c2c1.[BH4-].[Na+].[Na+].[OH-]>>COc1ccc(CNc2ccc3nc[nH]c3c2)cc1",
        "output": "359"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)I.CCC(C)=O.O=C([O-])[O-].O=Cc1ccc(O)cc1.[I-].[K+].[K+].[K+]>>CC(C)Oc1ccc(C=O)cc1",
        "output": "318"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=O.CCOC(=O)c1ccc2nc(-c3ccc(N4CCNCC4)nc3)sc2c1.CO.O=C(O)C(F)(F)F.[BH3-]C#N.[Na+]>>CCOC(=O)c1ccc2nc(-c3ccc(N4CCN(C)CC4)nc3)sc2c1",
        "output": "217"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CNC.Cl.ClCCl.O=Cc1cccc(Br)n1.[Na+]>>CN(C)Cc1cccc(Br)n1",
        "output": "829"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.CC(=O)[O-].O[C@H]1CO[C@@H]2[C@H](O)CO[C@H]12.[Na+]>>CC(=O)O[C@H]1CO[C@@H]2[C@H](O)CO[C@H]12",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(Oc1cnc(Cl)c(Cl)c1)C(=O)OC.[Na+].[OH-]>>CCC(Oc1cnc(Cl)c(Cl)c1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNCC1.Cc1nc2ccc(Br)cc2c(-c2ccc(S(C)(=O)=O)cc2)c1C(=O)C1CC1>>Cc1nc2ccc(N3CCCCC3)cc2c(-c2ccc(S(C)(=O)=O)cc2)c1C(=O)C1CC1",
        "output": "294"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN.CN(C)C=O.CN1CCN(C(=O)c2cc(-c3ccccc3)n(-c3ccc(Cl)nc3)n2)CC1.CO>>CNc1ccc(-n2nc(C(=O)N3CCN(C)CC3)cc2-c2ccccc2)cn1",
        "output": "70"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN.Cl.O.O=C(Cl)c1ccc(-c2nc(-c3ccc4c(c3)OCO4)c(-c3ccccn3)[nH]2)cc1>>CNC(=O)c1ccc(-c2nc(-c3ccc4c(c3)OCO4)c(-c3ccccn3)[nH]2)cc1",
        "output": "271"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-].c1ccc2c(c1)c1ccccc1c1ccccc21>>CC(=O)c1cccc2c3ccccc3c3ccccc3c12",
        "output": "31"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrP(Br)Br.OCCc1ccc(Cl)cc1>>Clc1ccc(CCBr)cc1",
        "output": "301"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CC[C@@H](O)C1.COC(=O)C(O)(c1cccs1)c1cccs1.Cc1ccccc1>>O=C(O)C(O)(c1cccs1)c1cccs1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CCO.Cl.NO.O.O=Cc1ccccc1[N+](=O)[O-].[Na+]>>O=[N+]([O-])c1ccccc1C=NO",
        "output": "30"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](Oc1ccc(Br)c(C=O)c1)(c1ccccc1)c1ccccc1.CO.ClCCl.[BH4-].[Na+]>>CC(C)(C)[Si](Oc1ccc(Br)c(CO)c1)(c1ccccc1)c1ccccc1",
        "output": "356"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC[C@H](C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc(-c2ccc3nc(C(=O)OC)ccc3c2)cc1.CO.Cl.[Na+].[OH-]>>CC[C@H](C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc(-c2ccc3nc(C(=O)O)ccc3c2)cc1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(-c2ccc(CN)cc2)n1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)Nc1cccc(-c2ccc(CNS(C)(=O)=O)cc2)n1",
        "output": "742"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "N#CC1(c2ccc(Br)cn2)CCC2(CC1)OCCO2.O=C(O)C(F)(F)F>>N#CC1(c2ccc(Br)cn2)CCC(=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C4(CC#N)CN(C5CCN(C(=O)Nc6ccc(F)cc6C(F)(F)F)CC5)C4)c3)ncnc21.ClCCl.NCCN.O=C(O)C(F)(F)F>>N#CCC1(n2cc(-c3ncnc4[nH]ccc34)cn2)CN(C2CCN(C(=O)Nc3ccc(F)cc3C(F)(F)F)CC2)C1",
        "output": "897"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cnc(N2CCN(C(=O)Nc3ccccc3)CC2CCC(=O)OC(C)(C)C)c(Cl)c1.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)c1cnc(N2CCN(C(=O)Nc3ccccc3)CC2CCC(=O)O)c(Cl)c1",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCN(Cc1ccc(C(F)(F)F)cc1)C(=O)COc1ccc(CCSc2ccccc2C(=O)OC)cc1.O.[Li+].[OH-]>>CCN(Cc1ccc(C(F)(F)F)cc1)C(=O)COc1ccc(CCSc2ccccc2C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CC[C@@H](NCc1ccccc1)[C@@H](C)O.ClCCl.O=C(Cl)CCl>>CC[C@H]([C@@H](C)O)N(Cc1ccccc1)C(=O)CCl",
        "output": "240"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)c1ccc2c(c1)OC1(O)c3cccc([N+](=O)[O-])c3C(=O)C21NC(=O)c1ccc2ccccc2n1.CCO.Cl.O.[Fe]>>CC(C)c1ccc2c(c1)OC1(O)c3cccc(N)c3C(=O)C21NC(=O)c1ccc2ccccc2n1",
        "output": "706"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccccc1Oc1c(Cl)nc(C2CC2)nc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1.NCCO>>COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCN",
        "output": "653"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.O.O=[N+]([O-])c1cnc2[nH]nc(OCCO)c2c1.[Cl-].[Fe].[NH4+]>>Nc1cnc2[nH]nc(OCCO)c2c1",
        "output": "269"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)CC1(C)SCCc2c1[nH]c1ccccc21.[K+].[OH-]>>CC1(CC(=O)O)SCCc2c1[nH]c1ccccc21",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.CC(C)(C)[O-].CCO.OCCCSc1ccc(O)cc1.[K+]>>OCCCSc1ccc(OCc2ccccc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCCC1(COCc1ccccc1)C(=O)NCC(=O)N1CCCC1.CO.[Pd]>>CC(C)(C)OC(=O)N1CCCC1(CO)C(=O)NCC(=O)N1CCCC1",
        "output": "178"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC1)CC(c1cccc(OCc3ccccc3)c1)CO2.CCOC(C)=O.CO.[H][H].[Pd]>>CC(C)(C)OC(=O)N1CCC2(CC1)CC(c1cccc(O)c1)CO2",
        "output": "23"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCCOc1cc2ncnc(Oc3cccc(N)c3)c2cc1OC.O=C(Nc1cc(C(F)(F)F)n(-c2ccccc2)n1)Oc1ccccc1>>COCCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(F)(F)F)n(-c5ccccc5)n4)c3)c2cc1OC",
        "output": "948"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)c1ncn(COCC[Si](C)(C)C)c1F.Cc1ccccc1.[H-]>>C[Si](C)(C)CCOCn1cnc(CO)c1F",
        "output": "286"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(S(=O)(=O)Cl)cc1.Cl.Cl.ClCCl.NCc1c(O[C@H](Cn2ccnc2)c2ccccc2)ccc2c1CCCC2=O.c1ccncc1>>COc1ccc(S(=O)(=O)NCc2c(O[C@H](Cn3ccnc3)c3ccccc3)ccc3c2CCCC3=O)cc1",
        "output": "530"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.Cc1ccc2c(c1)C(C)(C)c1cc(C)ccc1-2.ClCCl.O=[N+]([O-])O>>Cc1ccc2c(c1)C(C)(C)c1cc(C)cc([N+](=O)[O-])c1-2",
        "output": "21"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.ClCCl.NC(=O)c1c(F)cc(Cl)cc1Cl.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>N#Cc1c(F)cc(Cl)cc1Cl",
        "output": "374"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)Cl.Cl.O.O=C(O)CC1OB(O)c2cc(O)cc(F)c21.[Na+].[OH-]>>CCOC(=O)Oc1cc(F)c2c(c1)B(O)OC2CC(=O)O",
        "output": "261"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Nc1nc(Cl)ccc1[N+](=O)[O-].O=C([C@@H]1CCCNC1)N1CCCC1>>Nc1nc(N2CCC[C@@H](C(=O)N3CCCC3)C2)ccc1[N+](=O)[O-]",
        "output": "220"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccc2cccnc2c1.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cc1ccc2ccc[n+]([O-])c2c1",
        "output": "262"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O.OC[C@H](O)c1ccncc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OC[C@H](O)c1ccncc1",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCCN.CCN(CC)CC.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)NCCNC(=O)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc(Nc2cc3ccccc3c(Cl)n2)n[nH]1.OB(O)c1cccc(C(F)(F)F)c1>>Cc1cc(Nc2cc3ccccc3c(-c3cccc(C(F)(F)F)c3)n2)n[nH]1",
        "output": "865"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1c[nH]c2ccc(Br)cc12.CCC(C)=O.CCOC(=O)COc1ccc(S(=O)(=O)Cl)cc1C.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)COc1ccc(S(=O)(=O)n2cc(C(C)=O)c3cc(Br)ccc32)cc1C",
        "output": "648"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.C[C@H](c1ccccc1)N1CC[C@H](CO)C1.O.c1c[nH]cn1>>C[C@H](c1ccccc1)N1CC[C@H](CO[Si](C)(C)C(C)(C)C)C1",
        "output": "193"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.COc1ccc2c(C(=O)N(c3ccccc3)c3ccccc3)nn(-c3ccccc3C(=O)N3Cc4ccccc4C[C@H]3CNC(=O)OC(C)(C)C)c2c1.Cl.[Na+].[OH-]>>COc1ccc2c(C(=O)N(c3ccccc3)c3ccccc3)nn(-c3ccccc3C(=O)N3Cc4ccccc4C[C@H]3CN)c2c1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(C=O)cc2)CC1.CCO.ClCCl.NNc1ccc(-c2cnco2)cc1>>CC(C)(C)OC(=O)N1CCN(c2ccc(C=NNc3ccc(-c4cnco4)cc3)cc2)CC1",
        "output": "167"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(C(=O)N2[C@@H](c3nccs3)[C@@H](c3cnccn3)C[C@@]2(Cc2cscn2)C(=O)OC(C)(C)C)ccc1C(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>COc1cc(C(=O)N2[C@@H](c3nccs3)[C@@H](c3cnccn3)C[C@@]2(Cc2cscn2)C(=O)O)ccc1C(C)(C)C",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN1CCNCC1.O=c1[nH]c(Cl)cc2cc(O)c(O)cc12>>CN1CCN(c2cc3cc(O)c(O)cc3c(=O)[nH]2)CC1",
        "output": "220"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(Cl)OC(=O)Cl.CC1CCCN1CCCN1CCN(C2CCN(Cc3ccccc3)CC2)C1=C(C#N)C#N.ClCCCl>>CC1CCCN1CCCN1CCN(C2CCNCC2)C1=C(C#N)C#N",
        "output": "84"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCCCCC.CCOc1ccc(-c2nc3ccccn3c2-c2ccnc(Cl)n2)cc1C(=O)Nc1c(F)cccc1F.CO.COc1cc(N2CCN(C(C)C)CC2)ccc1N.C[O-].Cl.ClCCl.OCC(F)(F)F.[Na+]>>CCOc1ccc(-c2nc3ccccn3c2-c2ccnc(Nc3ccc(N4CCN(C(C)C)CC4)cc3OC)n2)cc1C(=O)Nc1c(F)cccc1F",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O.O=C1NC2(CNC2)n2c1c(Cl)cc(Br)c2=O.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CC2(C1)NC(=O)c1c(Cl)cc(Br)c(=O)n12",
        "output": "694"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(=O)[O-].CC(C)(O)Cn1cc(-c2ccc(Br)cc2)cn1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(O)Cn1cc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)cn1",
        "output": "942"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "B1C2CCCC1CCC2.C1CCOC1.C=CCC(O)[C@@H](Cc1ccccc1)N(C)C(=O)OC(C)(C)C.CCO.O.OO.[Na+].[OH-]>>CN(C(=O)OC(C)(C)C)[C@H](Cc1ccccc1)C(O)CCCO",
        "output": "465"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(CCCl)CCCl.Cl.ClCCl.Clc1ccccc1.Nc1cc([N+](=O)[O-])ccc1Br>>CN1CCN(c2cc([N+](=O)[O-])ccc2Br)CC1",
        "output": "640"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C1CCOC1.CC(C)COC(=O)Cl.CC(C)C[C@H](N)C(=O)OCc1ccccc1.CN1CCOCC1.C[C@H](NC(=O)OC(C)(C)C)C(=O)O.ClCCl>>CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1",
        "output": "132"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OC(CCCCC=CC(=O)NO)c1ccc2ccccc2c1.CCOC(C)=O.Cl.O>>O=C(C=CCCCCC(O)c1ccc2ccccc2c1)NO",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cl.Nc1ccc(CCCC(=O)O)cc1.O=N[O-].[I-].[K+].[Na+]>>O=C(O)CCCc1ccc(I)cc1",
        "output": "200"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.N#Cc1ccccc1-c1cc(-c2ccccc2[N+](=O)[O-])cn(-c2ccccc2)c1=O.[C].[H][H].[Pd]>>N#Cc1ccccc1-c1cc(-c2ccccc2N)cn(-c2ccccc2)c1=O",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(CCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)C(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1.CCCC[N+](CCCC)(CCCC)CCCC.O.[F-]>>CC(CCCO)C(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1",
        "output": "781"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(COc2ccc(Cn3cc(OC(c4ccccc4)c4ccccc4)c(=O)cc3CO)cc2OCc2ccc(OC)cc2)cc1.ClCCl.[Mn+4].[O-2].[O-2]>>COc1ccc(COc2ccc(Cn3cc(OC(c4ccccc4)c4ccccc4)c(=O)cc3C=O)cc2OCc2ccc(OC)cc2)cc1",
        "output": "263"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "OCCCc1c[nH]c2cc(Cl)ccc12.Oc1cccc2ccccc12.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Clc1ccc2c(CCCOc3cccc4ccccc34)c[nH]c2c1",
        "output": "550"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "B.C1CCOC1.Cc1ccc(Cl)cc1C(=O)NC1CC1>>Cc1ccc(Cl)cc1CNC1CC1",
        "output": "215"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.O=C(O)c1cnc(Br)cc1I.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cnc(Br)cc1I",
        "output": "415"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc2ncccc2c1.N#C[Cu].c1ccncc1>>N#Cc1ccc2ncccc2c1",
        "output": "531"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#CCCCOS(=O)(=O)c1ccc(C)cc1.COc1ccc(C=O)cc1O>>C#CCCCOc1cc(C=O)ccc1OC",
        "output": "438"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCS(=O)(=O)Cl.CCN(CC)CC.Cl.ClC(Cl)Cl.NC1Cc2ccc(C3=NNC(=O)CC3)cc2C1>>CCCCS(=O)(=O)NC1Cc2ccc(C3=NNC(=O)CC3)cc2C1",
        "output": "493"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CCOc1c(OC)cc([C@@H]2SC[C@@H](c3cc(OC)c(OC)c(OC)c3)S2)cc1[N+](=O)[O-].CCO.O.[Ca+2].[Cl-].[Cl-].[Zn]>>C=CCOc1c(N)cc([C@@H]2SC[C@@H](c3cc(OC)c(OC)c(OC)c3)S2)cc1OC",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1ncc(OC)cc1OC[C@H]1CCCN1C(=O)[C@H]1CC[C@H](C(F)(F)F)CC1.CCOC(=O)c1ncccc1OC[C@H]1CCCN1C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1CCC[C@@H]1COc1cccnc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1c(-c2ccccc2)c(=O)[nH]c2ccccc12.O=P(Cl)(Cl)Cl>>Cc1c(-c2ccccc2)c(Cl)nc2ccccc12",
        "output": "100"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#C[C@]1(O)CCN(C)C1=O.CNc1nccc2c1c(C(=O)OC)nn2-c1cccc(Br)c1>>CNc1nccc2c1c(C(=O)OC)nn2-c1cccc(C#C[C@]2(O)CCN(C)C2=O)c1",
        "output": "659"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC#N.CN.Cc1cccc(-c2nc3ccccn3c2-c2ccnc(S(C)(=O)=O)n2)n1>>CNc1nccc(-c2c(-c3cccc(C)n3)nc3ccccn23)n1",
        "output": "629"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.Cc1cccc(N)c1C.Clc1nc(Cl)nc(Cl)n1.O>>Cc1cccc(Nc2nc(Cl)nc(Cl)n2)c1C",
        "output": "592"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC)Cc1sc(-c2nc(-c3ccc(CCN)cc3)no2)cc1C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O=C(O)CO.On1nnc2ccccc21>>CCN(CC)Cc1sc(-c2nc(-c3ccc(CCNC(=O)CO)cc3)no2)cc1C",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrC(Br)(Br)Br.CC(C)(C)[Si](C)(C)OCc1cc(CO)ccc1O[Si](C)(C)C(C)(C)C.CCCCCCCCP(CCCCCCCC)CCCCCCCC.CCOCC>>CC(C)(C)[Si](C)(C)OCc1cc(CBr)ccc1O[Si](C)(C)C(C)(C)C",
        "output": "750"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCN(c2nccnc2Cl)CC1.CCCCP(CCCC)CCCC.CO.F[B-](F)(F)F.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])O.O=C([O-])[O-].OCc1ccc(B(O)O)cc1.[Cl-].[K+].[K+].[NH4+].[Na+].[Pd].[Pd]>>CC(C)(C)OC(=O)N1CCN(c2nccnc2-c2ccc(CO)cc2)CC1",
        "output": "875"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)OB(c2cn[nH]c2)OC1(C)C.CN(C)C=O.O=C([O-])[O-].OCCBr.[Cs+].[Cs+]>>CC1(C)OB(c2cnn(CCO)c2)OC1(C)C",
        "output": "577"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)N(NC(=O)c1ccccc1)C(=O)COc1cc(F)c(F)cc1Br.COCCOC.O=C([O-])[O-].OB(O)c1ccccc1OC(F)(F)F.[Na+].[Na+]>>CC(C)N(NC(=O)c1ccccc1)C(=O)COc1cc(F)c(F)cc1-c1ccccc1OC(F)(F)F",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C1COCCO1.CC(C)(C)OC(=O)n1ncc2c(Nc3ccc(I)cc3F)c([N+](=O)[O-])ccc21.O.O=C([O-])O.O=S([O-])S(=O)[O-].[Na+].[Na+].[Na+]>>CC(C)(C)OC(=O)n1ncc2c(Nc3ccc(I)cc3F)c(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)c1ccncc1.CS(=O)(=O)Cl.Cl.ClCCl.O.O=S(=O)(c1ccc2ccccc2c1)N1C[C@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1CO.c1ccncc1>>CS(=O)(=O)OC[C@@H]1C[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)CN1S(=O)(=O)c1ccc2ccccc2c1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.Cc1c(O)cccc1O.Cl.O.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>Cc1c(O)ccc(C=O)c1O",
        "output": "239"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)C(F)C(=O)Nc1ccc(-c2ccccc2)cc1.O.O.[Li]O>>O=C(O)C(F)C(=O)Nc1ccc(-c2ccccc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.Cc1sc(C=O)cc1CO[Si](C)(C)C(C)(C)C>>Cc1sc(C=O)cc1CO",
        "output": "708"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CNCC(O)c1ccc2c(c1)OCCO2.Cc1c(CCl)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12.O>>Cc1c(CN(C)CC(O)c2ccc3c(c2)OCCO3)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12",
        "output": "639"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#Cc1ccc(S(C)(=O)=O)cc1.CCOC(=O)COc1ccc(Sc2cc(Br)cc(Oc3cccc(C(F)(F)F)c3)c2)cc1C.CCOC(=O)COc1ccc(Sc2cc(C#Cc3ccc(CO)cc3)cc(OCCc3ccc(Cl)cc3)c2)cc1C>>CCOC(=O)COc1ccc(Sc2cc(C#Cc3ccc(S(C)(=O)=O)cc3)cc(Oc3cccc(C(F)(F)F)c3)c2)cc1C",
        "output": "659"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1[nH]c(C)c(-c2ccc(C(=O)O)cc2)c1C.CN(C)C=O.COc1cccc(N)c1.ClCCl.O=C(Cl)C(=O)Cl.O=C([O-])O.[Na+]>>CCOC(=O)c1[nH]c(C)c(-c2ccc(C(=O)Nc3cccc(OC)c3)cc2)c1C",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.N#Cc1ccc(Cl)cc1F.NC1CCCC1.O=C([O-])[O-].[K+].[K+]>>N#Cc1ccc(Cl)cc1NC1CCCC1",
        "output": "572"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC1CN(Cc2ccccc2)CCC1Nc1ccccc1F.COC(C)C(=O)Cl>>COC(C)C(=O)N(c1ccccc1F)C1CCN(Cc2ccccc2)CC1C",
        "output": "160"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CSc1ccc(Nc2c(C(=O)O)ccc(F)c2F)c(F)c1.NOCCO.O=C(n1ccnc1)n1ccnc1>>CSc1ccc(Nc2c(C(=O)NOCCO)ccc(F)c2F)c(F)c1",
        "output": "741"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=O.CCOC(=O)[C@@H]1CCCNC1.O=C([O-])O.O=CO.[Na+].[Na+].[OH-]>>CCOC(=O)[C@@H]1CCCN(C)C1",
        "output": "217"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COc1ccc(C=O)cc1O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[Cs+].[Cs+]>>COc1ccc(C=O)cc1Oc1ccc([N+](=O)[O-])cc1",
        "output": "564"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O.O=C(O)C1(c2ccccc2)CC2CCC(C1)N2.O=S(=O)([O-])[O-].[K+].[K+].[Na+].[OH-]>>CC(C)(C)OC(=O)N1C2CCC1CC(C(=O)O)(c1ccccc1)C2",
        "output": "694"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CI.CN(C)C=O.COC(=O)[C@H](Cc1ccc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)cc1)NC(=O)OC(C)(C)C.O=C([O-])[O-].[K+].[K+]>>COC(=O)[C@H](Cc1ccc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)cc1)NC(=O)OC(C)(C)C",
        "output": "570"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CN1CCNCC1.O=C(CCl)Nc1cccc(-c2cnc3ccccc3n2)c1>>CN1CCN(CC(=O)Nc2cccc(-c3cnc4ccccc4n3)c2)CC1",
        "output": "340"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)S(=O)(=O)c1ccc(CN)cc1.CCN(CC)CC.Cc1ccc(C(=O)O)c(=O)n1-c1cccc(C(F)(F)F)c1.ClCCl.O=S(Cl)Cl>>Cc1ccc(C(=O)NCc2ccc(S(=O)(=O)C(C)C)cc2)c(=O)n1-c1cccc(C(F)(F)F)c1",
        "output": "790"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=O.CC(=O)O.CCOCc1cc2cc(OCc3oc4cccc(OCCCNCc5cccnc5)c4c3C)ccc2o1.CO.[BH3-]C#N.[Na+]>>CCOCc1cc2cc(OCc3oc4cccc(OCCCN(C)Cc5cccnc5)c4c3C)ccc2o1",
        "output": "217"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.COc1ncnc2c1CNCC2.Cc1ccc(Br)c(C#N)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd]>>COc1ncnc2c1CN(c1ccc(C)cc1C#N)CC2",
        "output": "294"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(N2CCCc3ccc(-c4ccccc4)nc32)nc(N[C@@H](C)Cc2cccc([C@@H](C)NC(=O)OC(C)(C)C)c2)n1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(N2CCCc3ccc(-c4ccccc4)nc32)nc(N[C@@H](C)Cc2cccc([C@@H](C)N)c2)n1",
        "output": "793"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClC(Cl)Cl.Nc1ccc(C(CC(=O)O)CC(=O)O)cc1.S=C(Cl)Cl>>O=C(O)CC(CC(=O)O)c1ccc(N=C=S)cc1",
        "output": "114"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.O.O=C(CSc1ccccc1)NCC12CC3CC(CC(C3)C1)C2.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>c1ccc(SCCNCC23CC4CC(CC(C4)C2)C3)cc1",
        "output": "112"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O.CCN=C=NCCCN(C)C.CCO.CN(C)c1ccccn1.Cl.ClCCl>>CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)OC(C)(C)C",
        "output": "47"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CS(=O)(=O)[C@@H](c2ccccc2)CN(CC2CC2)C1=O.ClCCl.O=C(O)C(F)(F)F>>N[C@@H]1CS(=O)(=O)[C@@H](c2ccccc2)CN(CC2CC2)C1=O",
        "output": "431"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.C=C(OCC)c1cc(COCC(F)(F)F)nc(Cl)n1.CC(=O)[O-].CC(=O)[O-].COc1cc(N)ccc1-c1cnc(C)o1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(-c2ccccc2P(C2CCCCC2)C2CCCCC2)cc1>>C=C(OCC)c1cc(COCC(F)(F)F)nc(Nc2ccc(-c3cnc(C)o3)c(OC)c2)n1",
        "output": "808"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)C=Cc1ccc2nc(C)n(Cc3ccccc3Cl)c2c1.Cl.[Na+].[OH-]>>Cc1nc2ccc(C=CC(=O)O)cc2n1Cc1ccccc1Cl",
        "output": "58"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)Cn1ncc2ncccc21.Cl>>O=C(O)Cn1ncc2ncccc21",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCC(C(=O)OC)c1c(C)nc(-c2ccc(C)cc2)nc1-c1ccc(C)cc1.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc(-c2ccc(C)cc2)nc1-c1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COc1cc(C(=O)O)ccc1Cc1cn(C(C)=O)c2ccc([N+](=O)[O-])cc12.[Pd]>>COc1cc(C(=O)O)ccc1Cc1cn(C(C)=O)c2ccc(N)cc12",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(-c3cccc(NS(C)(=O)=O)c3)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12.N.O=C(O)C(F)(F)F>>Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cccc(NS(C)(=O)=O)c5)c34)n(-c3ccccc3)c(=O)c12",
        "output": "897"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.C[C@@H](Oc1ccc(C(C)(C)C)cc1C(C)(C)C)C(=O)O.ClCCl.O=C(Cl)C(=O)Cl>>C[C@@H](Oc1ccc(C(C)(C)C)cc1C(C)(C)C)C(=O)Cl",
        "output": "56"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=C1CC(CCCCl)S(=O)(=O)c2ccccc21.[BH4-].[Na+]>>O=S1(=O)c2ccccc2C(O)CC1CCCCl",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#CCCCCCCCCCCC.O=Cc1cccc(Br)c1>>CCCCCCCCCCCC#Cc1cccc(C=O)c1",
        "output": "659"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.CCOC(C)=O.CI.O.O=C([O-])[O-].Oc1cc(Br)cc(Br)c1.[K+].[K+]>>COc1cc(Br)cc(Br)c1",
        "output": "62"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cc1ccccc1S(=O)(=O)O.NCCCCCC(=O)O>>CCOC(=O)CCCCCN",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCC1CC1.COc1cc2ncnc(N3CCC(n4c(=O)[nH]c5ccc([N+](=O)[O-])cc5c4=O)CC3)c2cc1OC>>COc1cc2ncnc(N3CCC(n4c(=O)c5cc([N+](=O)[O-])ccc5n(CC5CC5)c4=O)CC3)c2cc1OC",
        "output": "327"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN1CCCC1=O.Nc1cccc(N)c1.O.O=S(=O)(c1ccccc1)n1cc(-c2nc(Cl)ncc2Cl)c2ccccc21>>Nc1cccc(Nc2ncc(Cl)c(-c3cn(S(=O)(=O)c4ccccc4)c4ccccc34)n2)c1",
        "output": "808"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)c1sc2ncnc(Nc3ccc(F)cc3O[C@H]3CCC[C@H](O)C3)c2c1C.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li+].[OH-]>>Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3O[C@H]3CCC[C@H](O)C3)c12",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CN(C)C=O.O=C(Cl)C(=O)Cl.O=C(O)C(CCCCl)c1ccccc1C(F)(F)F>>O=C(Cl)C(CCCCl)c1ccccc1C(F)(F)F",
        "output": "56"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCCSC(c1ccccc1)(c1ccccc1)c1ccccc1>>CS(=O)(=O)OCCSC(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(=O)NCC1OC(=O)N2c3ccccc3CC12.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>CC(=O)NCC1OC(=O)N2c3ccc(Br)cc3CC12",
        "output": "4"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CS(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)O)cc1C(F)(F)F.ClCCl.Nc1ccccn1.O=C1CCC(=O)N1Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccncc1>>CS(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)Nc2ccccn2)cc1C(F)(F)F",
        "output": "368"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(Nc1ccccc1C(=O)Nc1ccc(Cl)cn1)OC1CCNC1.O=C(O)C(F)(F)F.O=C1CCCCC1.[BH3-]C#N.[Na+]>>O=C(Nc1ccccc1C(=O)Nc1ccc(Cl)cn1)OC1CCN(C2CCCCC2)C1",
        "output": "187"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCCc1ccc(C#Cc2ccc(CN(Cc3ccc(OCC(=O)OC)cc3)C(=O)c3cn[nH]c3)cc2)cc1.CO.[Na+].[OH-]>>CCCCc1ccc(C#Cc2ccc(CN(Cc3ccc(OCC(=O)O)cc3)C(=O)c3cn[nH]c3)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.CN(C)C=O.Cc1cc(Br)cnc1NC(=O)CCl.O.O=C([O-])[O-].[K+].[K+]>>Cc1cc(Br)cnc1NC(=O)CN1CCCC1",
        "output": "340"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CN(C)CCN(C)c1ccc(C#N)cc1C(F)(F)F.O.[Na+].[OH-]>>CN(C)CCN(C)c1ccc(C(=O)O)cc1C(F)(F)F",
        "output": "445"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Clc1ncc(Br)c(Cl)n1.NC1CCN(Cc2ccccc2)CC1.O.O=C([O-])[O-].[K+].[K+]>>Clc1ncc(Br)c(NC2CCN(Cc3ccccc3)CC2)n1",
        "output": "166"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CN(C)CCCN.O=C(O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(F)n1>>CN(C)CCCNC(=O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(F)n1",
        "output": "697"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)CN1C(=O)SC(Cc2ccc(N3CCC(=O)CC3)cc2)C1=O.CN(C)C=O.CS(=O)(=O)Nc1cc([C@@H](O)CN)ccc1O.[Na+]>>CC(C)(C)OC(=O)CN1C(=O)SC(Cc2ccc(N3CCC(NC[C@H](O)c4ccc(O)c(NS(C)(=O)=O)c4)CC3)cc2)C1=O",
        "output": "236"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCCBr.CC#N.O=C([O-])[O-].Oc1ccccc1-c1csc(C(F)(F)F)n1.[Cs+].[Cs+]>>FC(F)(F)c1nc(-c2ccccc2OCCBr)cs1",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "[H][H].[N-]=[N+]=NCC(O)CN1CCOCC1.[OH-].[OH-].[Pd+2]>>NCC(O)CN1CCOCC1",
        "output": "89"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CC2(CCN1)OCCO2.CCC(C)=O.NC(=O)c1ccnc(Cl)n1.O=C([O-])[O-].[K+].[K+]>>NC(=O)c1ccnc(N2CCC3(CC2)OCCO3)n1",
        "output": "36"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.COC(=O)c1cc(C)cc(OC)c1C1=C(OC)C(=O)c2c(O)cccc2C1=O.O.c1ccncc1>>COC(=O)c1cc(C)cc(OC)c1C1=C(OC)C(=O)c2c(OC(C)=O)cccc2C1=O",
        "output": "46"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1cccc(Oc2ccccc2)c1.C1CCOC1.Cc1ccc(S(=O)(=O)OCC2(COS(=O)(=O)c3ccc(C)cc3)CCC(=O)CC2)cc1.[Li]CCCC>>Cc1ccc(S(=O)(=O)OCC2(COS(=O)(=O)c3ccc(C)cc3)CCC(O)(c3cccc(Oc4ccccc4)c3)CC2)cc1",
        "output": "321"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Nc1cccc(C(=O)O)c1O.O=S(=O)(O)O>>CCOC(=O)c1cccc(N)c1O",
        "output": "33"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=Cc1cccc(Br)c1F.[BH4-].[Na+]>>OCc1cccc(Br)c1F",
        "output": "356"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.CCCCP(CCCC)CCCC.COC(=O)Cc1ccc(OC)cc1O.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>COc1ccc(CC(=O)O)c(OCCCc2cn(-c3ccc(C(F)(F)F)cn3)nc2C(C)C)c1",
        "output": "928"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Nc1ccc(OCCCCl)cc1.CN(C)C=O.N#N.Oc1ccc(Cl)c(Cl)c1.[H-].[Na+]>>CC(=O)Nc1ccc(OCCCOc2ccc(Cl)c(Cl)c2)cc1",
        "output": "74"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC)C(=O)CCCC[C@@H]1CC[C@@H](NC)CC1.CN(C)c1ccncc1.Cl.ClCCl.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1>>CCN(CC)C(=O)CCCC[C@@H]1CC[C@@H](N(C)S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1",
        "output": "99"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCC.CC[SiH](CC)CC.COC(C)(C)C.O=C1Nc2ccccc2C1(O)c1cc2c(cc1O)OCO2>>O=C1Nc2ccccc2C1c1cc2c(cc1O)OCO2",
        "output": "964"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.Cc1ccc(S(=O)(=O)Nc2cc(F)ccc2F)cc1.O.O=N[O-].O=[N+]([O-])O.[Na+]>>Cc1ccc(S(=O)(=O)Nc2cc(F)c([N+](=O)[O-])cc2F)cc1",
        "output": "21"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCO.CCOC(=O)c1cc2ccncc2n1C.[Na+].[OH-]>>Cn1c(C(=O)O)cc2ccncc21",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)Cc1ccccc1O.COc1ccc(CO)cc1Br>>COC(=O)Cc1ccccc1OCc1ccc(OC)c(Br)c1",
        "output": "347"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN1CCN(C(=O)c2ccc(N)cc2Cl)CC1.CO.ClCCl>>CCN1CCN(Cc2ccc(N)cc2Cl)CC1",
        "output": "215"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(-c2oncc2C(=O)O)cc1.Clc1ccccc1C1CCNC1.O=C(O)C(=O)O>>Cc1ccc(-c2oncc2C(=O)N2CCC(c3ccccc3Cl)C2)cc1",
        "output": "975"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C(O)CCCCCN1C(=O)C=CC1=O.O=S(Cl)Cl>>O=C(Cl)CCCCCN1C(=O)C=CC1=O",
        "output": "53"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCC=O.CCOC(=O)c1cccc2nc(N3CC[C@H](NC(=O)c4nc(Cl)c(CC)[nH]4)[C@H](N)C3)sc12.[Na+]>>CCCN[C@@H]1CN(c2nc3cccc(C(=O)OCC)c3s2)CC[C@@H]1NC(=O)c1nc(Cl)c(CC)[nH]1",
        "output": "426"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)CCc1ccc(C(c2cc(F)ccc2F)S(=O)(=O)c2ccc(Cl)cc2)nc1.O=S(=O)([O-])O.[Li+].[Na+].[OH-]>>O=C(O)CCc1ccc(C(c2cc(F)ccc2F)S(=O)(=O)c2ccc(Cl)cc2)nc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1C(=O)C2(CC2)c2cc(N)c([N+](=O)[O-])cc21.CO.Cl.[Pd]>>CN1C(=O)C2(CC2)c2cc(N)c(N)cc21",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)C(=O)O.CN(C)c1ccncc1.Cc1ccc2c(c1)c1c(n2CCN)CCN(C)C1.ClCCl>>Cc1ccc2c(c1)c1c(n2CCNC(=O)C(C)C)CCN(C)C1",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCBr.CCOc1cc(Cc2cnc(N)nc2N)cc(O)c1-c1ccc(OC)cc1>>CCCOc1cc(Cc2cnc(N)nc2N)cc(OCC)c1-c1ccc(OC)cc1",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.N.O=C(NCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1ccccc1[N+](=O)[O-].[H][H].[Ni]>>Nc1ccccc1C(=O)NCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1",
        "output": "486"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NCCc1ccc2ccccc2c1.O=CC1CC1>>c1ccc2cc(CCNCC3CC3)ccc2c1",
        "output": "426"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.Clc1ccc2c(Cl)ccnc2c1.Nc1ccc(F)cc1>>Fc1ccc(Nc2ccnc3cc(Cl)ccc23)cc1",
        "output": "115"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)O.CCCC[N+](CCCC)(CCCC)CCCC.COC(C)(C)C.COc1cc(/C=C\\c2ccc([N+](=O)[O-])c(O)c2O[Si](C)(C)C(C)(C)C)cc(OC)c1OC.[F-]>>COc1cc(/C=C\\c2ccc([N+](=O)[O-])c(O)c2O)cc(OC)c1OC",
        "output": "754"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCO.O.O.O=C(Cc1ccc([N+](=O)[O-])cc1)Nc1n[nH]c2ncc(Sc3cc(F)cc(F)c3)cc12.[Cl-].[Fe].[NH4+]>>Nc1ccc(CC(=O)Nc2n[nH]c3ncc(Sc4cc(F)cc(F)c4)cc23)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N1CCC(CC(=O)Nc2ccc(Br)cc2)CC1.OB(O)c1ccc(F)cc1>>CC(=O)N1CCC(CC(=O)Nc2ccc(-c3ccc(F)cc3)cc2)CC1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[Si](C)(C)Cl.ClCCl.OCCc1ccc(-n2cnc(-c3ccccc3)c2)cc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCc1ccc(-n2cnc(-c3ccccc3)c2)cc1",
        "output": "193"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.Clc1nc2ccccc2nc1NC1CC1>>CC(C)(C)OC(=O)N1CCN(c2nc3ccccc3nc2NC2CC2)CC1",
        "output": "505"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C1Cc2c(cccc2-c2ccncc2)N1.O=Cc1cc2c([nH]1)CCCC2>>O=C1Nc2cccc(-c3ccncc3)c2C1=Cc1cc2c([nH]1)CCCC2",
        "output": "440"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)c1ccn(C2CCN(Cc3cc(C4CC4)c(-c4ccc(F)cc4)c(F)c3OC(C)C)CC2)c(=O)c1C.Cl.O.[Na+].[OH-]>>Cc1c(C(=O)O)ccn(C2CCN(Cc3cc(C4CC4)c(-c4ccc(F)cc4)c(F)c3OC(C)C)CC2)c1=O",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCC(N)CC1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.N#Cc1ccc(CC(=O)O)cc1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCC(NC(=O)Cc2ccc(C#N)cc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCC.CCOCC.C[Si](C)(C)C#Cc1ccc(OC(F)F)cc1.ClCCl.O=C([O-])[O-].[Cs+].[Cs+]>>C#Cc1ccc(OC(F)F)cc1",
        "output": "337"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)c1oc2cccc(OCCCNC(C)(C)C)c2c1C.ClCCl>>CCOC(=O)c1oc2cccc(OCCCN(C(=O)OC(C)(C)C)C(C)(C)C)c2c1C",
        "output": "694"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C[C@@H](C(=O)N[C@@H]1CC[C@H]2CNC[C@H]21)N1CCOCC1.CCN(CC)CC.ClCCl.O=S(=O)(Cl)c1cccc(C(F)(F)F)c1>>CC(C)C[C@@H](C(=O)N[C@@H]1CC[C@H]2CN(S(=O)(=O)c3cccc(C(F)(F)F)c3)C[C@H]21)N1CCOCC1",
        "output": "99"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1ccc(C(=O)O)cc1.COc1cc(NC(C)=O)ccc1Br.ClCCCl.ClCCl.Cl[Sn](Cl)(Cl)Cl.O=P(Cl)(Cl)Cl>>CCc1ccc(C(=O)c2cc(Br)c(OC)cc2NC(C)=O)cc1",
        "output": "275"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=C1c2ccccc2C(=O)N1[C@@H]1CC[C@@H](c2cccnc2)C1>>N[C@@H]1CC[C@@H](c2cccnc2)C1",
        "output": "242"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)SC1CCC2(CCC(CCc3ccoc3)CC2)CC1.CO.N.[H][H]>>SC1CCC2(CC1)CCC(CCc1ccoc1)CC2",
        "output": "90"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCO.CCOC(C)=O.CSc1cc(F)c(F)cc1-c1ccc(OCc2cccc(C(=O)N(CCC#N)CC(=O)O)c2)cc1.Cl.ClCCl.O.On1nnc2ccccc21>>CCOC(=O)CN(CCC#N)C(=O)c1cccc(COc2ccc(-c3cc(F)c(F)cc3SC)cc2)c1",
        "output": "47"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN.COc1cc(C(=O)O)ccc1N.Cl>>CNC(=O)c1ccc(N)c(OC)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CNC(=O)CC(c1ccc2c(OC)n[nH]c2c1)c1cccc(C)n1.CNCCC(c1ccccc1)c1cccc2cc[nH]c12.O=C(O)C(F)(F)F>>CNCCC(c1ccc2c(OC)n[nH]c2c1)c1cccc(C)n1",
        "output": "112"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)/C=C(\\c1ccc(CC)cc1)n1cnc2ccccc21.Cl>>CCc1ccc(/C(=C\\C(=O)O)n2cnc3ccccc32)cc1",
        "output": "122"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.OCc1ccc(Br)c2nsnc12.[Mn+4].[O-2].[O-2]>>O=Cc1ccc(Br)c2nsnc12",
        "output": "520"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1c(-c2ccccc2F)nc2ccccc2c1O.O=P(Cl)(Cl)Cl>>Cc1c(-c2ccccc2F)nc2ccccc2c1Cl",
        "output": "177"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(C)=O.Cc1nn(C)c(Oc2c(F)cc([N+](=O)[O-])cc2F)c1-c1c(F)cc(F)cc1F.O.[Cl-].[Fe].[NH4+]>>Cc1nn(C)c(Oc2c(F)cc(N)cc2F)c1-c1c(F)cc(F)cc1F",
        "output": "335"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CN1CCNCC1.Clc1cc(NN=C(c2ccccc2)c2ccccc2)ncn1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>CN1CCN(c2cc(NN=C(c3ccccc3)c3ccccc3)ncn2)CC1",
        "output": "162"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.Fc1cnc(Cl)nc1Cl.Nc1ccccc1N>>Nc1ccccc1Nc1nc(Cl)ncc1F",
        "output": "352"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCC.CCCCCCCCCCCCS.CCOC(C)=O.COc1ccccc1C(=O)c1ccccc1SC.O.[Al+3].[Cl-].[Cl-].[Cl-]>>CSc1ccccc1C(=O)c1ccccc1O",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(C)=O.CCCI.NC(=O)C1CCNCC1.O=C([O-])[O-].[K+].[K+]>>CCCN1CCC(C(N)=O)CC1",
        "output": "184"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)[O-].OB(O)c1ccc(F)cc1.[Cu+2].c1ccncc1.c1cn[nH]c1>>Fc1ccc(-n2cccn2)cc1",
        "output": "925"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN1CCc2ccc(Nc3nccc(-c4sc(C5CCNCC5)nc4-c4cccc(NC(=O)c5c(F)cccc5F)c4)n3)cc2C1.CO.ClCCl.[Na+]>>CN1CCC(c2nc(-c3cccc(NC(=O)c4c(F)cccc4F)c3)c(-c3ccnc(Nc4ccc5c(c4)CN(C)CC5)n3)s2)CC1",
        "output": "217"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COC(=O)c1c(CS(=O)(=O)c2ccccc2)ccc(-c2ccoc2)c1OCCN(C)C(=O)OC(C)(C)C.O.O.[Li+].[OH-]>>CN(CCOc1c(-c2ccoc2)ccc(CS(=O)(=O)c2ccccc2)c1C(=O)O)C(=O)OC(C)(C)C",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.ClC(Cl)Cl.Cn1nc(COCc2ccc3ccccc3c2)c(Cl)c1C(=O)O.NCC1CCOC1.On1nnc2ccccc21>>Cn1nc(COCc2ccc3ccccc3c2)c(Cl)c1C(=O)NCC1CCOC1",
        "output": "816"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1ccc(OC)c(/C=C/c2ccc(OC(F)(F)F)cc2)c1.CO.Cl.[K+].[OH-]>>COc1ccc(C(=O)O)cc1/C=C/c1ccc(OC(F)(F)F)cc1",
        "output": "386"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)n1c(-c2ccccc2C#N)nc2cc(Br)ccc21.CCO.NO>>CC(C)(C)n1c(-c2ccccc2C(=N)NO)nc2cc(Br)ccc21",
        "output": "854"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)[C@@H]1C[C@H]1c1ccc(C(F)(F)F)nc1.Cl.O>>O=C(O)[C@@H]1C[C@H]1c1ccc(C(F)(F)F)nc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CN2CCC(CC2)N1.CC#N.CNS(=O)(=O)c1cc(F)ccc1[N+](=O)[O-].O.O=C(O)C(F)(F)F.O=C([O-])[O-].[K+].[K+]>>CNS(=O)(=O)c1cc(N2CCN3CCC2CC3)ccc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.CSc1ccc(C(=O)O)c(O)c1.O.O=S(=O)(O)O>>CSc1ccc(C(=O)O)c(OC(C)=O)c1",
        "output": "46"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Cl.CC(C)(CC(=O)O)S(=O)(=O)c1cccc(C(F)(F)F)c1.CO>>COC(=O)CC(C)(C)S(=O)(=O)c1cccc(C(F)(F)F)c1",
        "output": "195"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCNC(=O)COC(c1cccc(Cl)c1)[C@@H]1CCCNC1.CN(C[C@@H](N)CC1CCCCC1)C(=O)OC(C)(C)C.ClCCl.O=C(n1ccnc1)n1ccnc1>>CCNC(=O)COC(c1cccc(Cl)c1)[C@@H]1CCCN(C(=O)N[C@@H](CC2CCCCC2)CN(C)C(=O)OC(C)(C)C)C1",
        "output": "734"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN.CSc1ncc2c(n1)N1CCC[C@H]1CN(c1cccn3c(=O)ccnc13)C2=O.ClC(Cl)Cl.ClCCl.O=C(OO)c1cccc(Cl)c1>>CCNc1ncc2c(n1)N1CCC[C@H]1CN(c1cccn3c(=O)ccnc13)C2=O",
        "output": "101"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O.O=Cc1ccc(C2CC2)cc1.[BH4-].[Li+]>>OCc1ccc(C2CC2)cc1",
        "output": "356"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CI.CN(C)C=O.C[C@@H]1C(=O)NCCN1C[C@H]1CN(C(=O)OC(C)(C)C)[C@H](C)CN1CC(=O)N1CC(C)(C)c2ncc(Cc3ccc(F)cc3)cc21.O.[H-].[Na+]>>C[C@@H]1C(=O)N(C)CCN1C[C@H]1CN(C(=O)OC(C)(C)C)[C@H](C)CN1CC(=O)N1CC(C)(C)c2ncc(Cc3ccc(F)cc3)cc21",
        "output": "83"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)c1cc2cc(Br)c3scc(C)c3c2[nH]1.O.[Na+].[OH-]>>Cc1csc2c(Br)cc3cc(C(=O)O)[nH]c3c12",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.COCCl.COc1ccc(Br)cc1CCO.ClCCl.O.[NH4+].[OH-]>>COCOCCc1cc(Br)ccc1OC",
        "output": "598"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C[O-].N#Cc1ccc(Br)cc1F.[K+]>>COc1cc(Br)ccc1C#N",
        "output": "485"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN.O=C(O)C1(c2ccc(F)cc2)CCCCC1>>CNC(=O)C1(c2ccc(F)cc2)CCCCC1",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)CCSc1cc2cc(Cl)ccc2[nH]1.CI.CN(C)C=O.[H-].[Na+]>>Cn1c(SCCC(=O)OC(C)(C)C)cc2cc(Cl)ccc21",
        "output": "191"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)Cn1cc(Cl)c2ccc(O[Si](C)(C)C(C)(C)C)cc21.CCCC[N+](CCCC)(CCCC)CCCC.O.[F-]>>CC(C)(C)OC(=O)Cn1cc(Cl)c2ccc(O)cc21",
        "output": "754"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)Cc1c2n(c3c(F)cccc13)CC(n1nnc(C)c1Cc1ccc(F)cc1)CC2.CCOC(C)=O.CO.O.[Li+].[OH-]>>Cc1nnn(C2CCc3c(CC(=O)O)c4cccc(F)c4n3C2)c1Cc1ccc(F)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1cn(CC)c2cc(F)c(I)cc2c1=O.Cl.[Na+].[OH-]>>CCn1cc(C(=O)O)c(=O)c2cc(I)c(F)cc21",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)COc1cccc(C(=O)OC)c1.NN.O.O>>COC(=O)c1cccc(OCC(=O)NN)c1",
        "output": "130"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)[C@H](CC1CCCCC1)N(Cc1ccccc1)Cc1ccccc1.[Na+].[OH-]>>O=C(O)[C@H](CC1CCCCC1)N(Cc1ccccc1)Cc1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(=O)O.CCc1cc(Cl)nc(-c2cccc(Cl)c2)n1.Cl.NC(=O)Cc1ccc(N)cc1.O=C([O-])O.[Na+]>>CCc1cc(Nc2ccc(CC(N)=O)cc2)nc(-c2cccc(Cl)c2)n1",
        "output": "161"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cc1ccc(C(=O)O)c(O)c1.O=S(Cl)Cl>>COC(=O)c1ccc(C)cc1O",
        "output": "33"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC1(C)[C@H]2CC[C@]1(C)[C@H](O)C2.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.O=C(O)CCC(=O)OCc1ccccc1.On1nnc2ccccc21>>CC1(C)[C@H]2CC[C@]1(C)[C@H](OC(=O)CCC(=O)OCc1ccccc1)C2",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1ccc(-c2ccccn2)cc1.C1COCCO1.CC(=O)[O-].CC(=O)[O-].CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Nc1nc2ccc(S(=O)(=O)c3ccccc3)cn2n1.O.[Pd+2]>>O=S(=O)(c1ccccc1)c1ccc2nc(Nc3ccc(-c4ccccn4)cc3)nn2c1",
        "output": "970"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CC1(C(=O)O)CCCN(c2ccc([N+](=O)[O-])cc2)C1.CCN(CC)CC.[NH4+].[OH-]>>CC1(C(N)=O)CCCN(c2ccc([N+](=O)[O-])cc2)C1",
        "output": "313"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)CCCc1cccc2nc(NCc3ccc(C)o3)ccc12.[BH4-].[Li+]>>Cc1ccc(CNc2ccc3c(CCCCO)cccc3n2)o1",
        "output": "343"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CN1CCNCC1.CS(=O)(=O)OCCc1cccc(CCc2ccc(OCc3ccccc3)nn2)c1.O=C([O-])[O-].[K+].[K+]>>CN1CCN(CCc2cccc(CCc3ccc(OCc4ccccc4)nn3)c2)CC1",
        "output": "496"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1ccc(B(O)O)cc1.Cc1c2n(c3c(Br)cc(F)cc13)CCNC2=O>>Cc1c2n(c3c(-c4ccc(C(C)(C)C)cc4)cc(F)cc13)CCNC2=O",
        "output": "833"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.Nc1ccccc1O.O=C(Cl)c1cccnc1Cl>>O=C(Nc1ccccc1O)c1cccnc1Cl",
        "output": "642"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(C)(C(=O)C(Oc1ccc(Cl)cc1Cl)n1cncn1)C(Cl)Cl.CO.O=B[O-].[Na+]>>CC(C)(C(Cl)Cl)C(O)C(Oc1ccc(Cl)cc1Cl)n1cncn1",
        "output": "91"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCc1c(O)ccc2c1CCC(C)(C)C2=O.CCOC(C)=O.CI.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>C=CCc1c(OC)ccc2c1CCC(C)(C)C2=O",
        "output": "62"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(CN)(c1ccccc1)c1ccccc1.CCN(CC)CC.CN(C)C=O.Cl.OC[C@H]1O[C@@H](n2cnc3c(Cl)ncnc32)[C@H](O)[C@@H]1O>>CC(CNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)(c1ccccc1)c1ccccc1",
        "output": "145"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)C(C#N)C1CC1.[Na+].[OH-]>>N#CC(C(=O)O)C1CC1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].COC(=O)c1cnc(Cl)cn1.C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C4(CC#N)CNC4)c3)ncnc21.Cc1ccccc1.Cl.Cl.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COC(=O)c1cnc(N2CC(CC#N)(n3cc(-c4ncnc5c4ccn5COCC[Si](C)(C)C)cn3)C2)cn1",
        "output": "505"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1ccc(Br)cc1.CC(C)N1CCCN(C(=O)[C@H]2CCNC2)CC1>>CC(=O)c1ccc(N2CC[C@H](C(=O)N3CCCN(C(C)C)CC3)C2)cc1",
        "output": "294"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN.COC(=O)c1ccc(C(F)(F)C(F)(F)Cl)[nH]c1=O.Cl>>CCNC(=O)c1ccc(C(F)(F)C(F)(F)Cl)[nH]c1=O",
        "output": "862"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cl.Cl.O=[N+]([O-])c1ccc2c(c1)C1CCCN1CC2.[H][H].[Pd]>>Nc1ccc2c(c1)C1CCCN1CC2",
        "output": "71"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.CN(C)C=O.CN(C)c1ccncc1.Cc1cc2c3c(c1)c1c(OCCN)cccc1n3C(c1ccccc1)CO2>>CC(=O)NCCOc1cccc2c1c1cc(C)cc3c1n2C(c1ccccc1)CO3",
        "output": "339"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1cn(CCC(C)(C)NCC(O)c2cccc(NS(=O)(=O)c3ccccc3)c2)cn1.[Na+].[OH-]>>CC(C)(CCn1cnc(C(=O)O)c1)NCC(O)c1cccc(NS(=O)(=O)c2ccccc2)c1",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CO.COC(=O)Cc1cc(C2CCCC2)c(O)cc1[N+](=O)[O-].O.[Zn]>>COC(=O)Cc1cc(C2CCCC2)c(O)cc1N",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(Cl)Cl.CCC(=O)Cl.CCN(C(C)C)C(C)C.Nc1cc(Br)cc(C(=O)c2cccnc2)c1.O=C([O-])O.[Na+]>>CCC(=O)Nc1cc(Br)cc(C(=O)c2cccnc2)c1",
        "output": "9"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)N=NC(=O)OCC.CN(C)CCO.COc1ccc(-c2[nH]c(-c3ccc(O)cc3)nc2C(=O)Nc2nccs2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(-c2[nH]c(-c3ccc(OCCN(C)C)cc3)nc2C(=O)Nc2nccs2)cc1",
        "output": "478"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC(C)C(=O)Cl.CCCC(C)C(=O)N=C=S.CCCC(C)C(=O)O.CCO.COc1cc2nccc(Oc3ccc(N)cc3Cl)c2cc1OC.Cc1ccccc1.O=S(Cl)Cl>>CCCC(C)C(=O)NC(=S)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(Cl)c1",
        "output": "961"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCN.COc1ccc2c(C(=O)O)c(C)n(C)c2c1.O=C(Cl)C(=O)Cl>>CCCCNC(=O)c1c(C)n(C)c2cc(OC)ccc12",
        "output": "674"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCCC(C(=O)O)C1.Nc1ccccc1Br>>CC(C)(C)OC(=O)N1CCCC(C(=O)Nc2ccccc2Br)C1",
        "output": "365"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#CCC(CC#CC)(C(=O)OC(C)(C)C)S(=O)(=O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1.ClCCl.O=C(O)C(F)(F)F>>CC#CCC(CC#CC)(C(=O)O)S(=O)(=O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(CBr)cc1.[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1",
        "output": "248"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)c1ccncc1.COC(=O)CC1CCC(c2ccc(-c3ccc(N)cn3)cc2)CC1.ClCCl.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1.c1ccncc1>>COC(=O)CC1CCC(c2ccc(-c3ccc(NS(=O)(=O)c4ccc(C(F)(F)F)cc4)cn3)cc2)CC1",
        "output": "554"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CN(CCN)C(=O)OC(C)(C)C.CS(=O)(=O)OCCNC(=O)OCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>CN(CCNCCNC(=O)OCc1ccccc1)C(=O)OC(C)(C)C",
        "output": "559"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrBr.CC(=O)C1CCC(NC(=O)OCC2c3ccccc3-c3ccccc32)CC1.CO>>O=C(NC1CCC(C(=O)CBr)CC1)OCC1c2ccccc2-c2ccccc21",
        "output": "173"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)C(Cc1ccc(NC(=O)C2CCCN2C(=O)CC(Cc2ccccc2)NC(=O)OC(C)(C)C)cc1)NC(=O)C(CSC(C)=O)Cc1ccccc1.O=C(O)C(F)(F)F>>COC(=O)C(Cc1ccc(NC(=O)C2CCCN2C(=O)CC(N)Cc2ccccc2)cc1)NC(=O)C(CSC(C)=O)Cc1ccccc1",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.COc1ccc(CCl)cc1.O.O=C([O-])[O-].O[C@H]1CC(F)(F)CC[C@@H]1c1cn[nH]c1.[K+].[K+]>>COc1ccc(Cn2cc([C@H]3CCC(F)(F)C[C@@H]3O)cn2)cc1",
        "output": "842"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.C=CCc1cc(-c2ccccc2C)ccc1O>>C=CCc1cc(-c2ccccc2C)ccc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CI.CN(C)C=O.COc1cccc2c(=O)c3c(O)cc(OCc4ccccc4)cc3oc12.O=C([O-])[O-].[Cs+].[Cs+]>>COc1cccc2c(=O)c3c(OC)cc(OCc4ccccc4)cc3oc12",
        "output": "62"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CCn1cc(C(=O)O)c(=O)c2cnc(N3CCN(Cc4ccc([N+](=O)[O-])cc4)CC3)nc21.[H][H].[Pd]>>CCn1cc(C(=O)O)c(=O)c2cnc(N3CCN(Cc4ccc(N)cc4)CC3)nc21",
        "output": "507"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(O)cn1.N#Cc1cc(C=O)ccc1F>>Cc1ccc(Oc2ccc(C=O)cc2C#N)cn1",
        "output": "845"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1ccc(C(=O)c2ccc(O)cc2)cc1.COc1cc2nccc(Cl)c2cc1OC>>COc1cc2nccc(Oc3ccc(C(=O)c4ccc(C(C)(C)C)cc4)cc3)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1cc(C)[nH]c(=O)c1CN.Cc1nn(C(C)C)c2cc(Br)cc(C(=O)O)c12>>CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(Br)cc2c1c(C)nn2C(C)C",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CNC.Cl.F[P-](F)(F)(F)(F)F.Nc1ccc(-c2nc(N3CCOCC3)c3cc(C(=O)O)cn3n2)cc1.O.O=C([O-])[O-].[K+].[K+]>>CN(C)C(=O)c1cc2c(N3CCOCC3)nc(-c3ccc(N)cc3)nn2c1",
        "output": "256"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C[C@](C)(NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)NCc1cc(Cl)ccc1-n1cnnn1.ClCCl.O=C(O)C(F)(F)F>>CC(C)C[C@](C)(N)C(=O)N1CCC[C@H]1C(=O)NCc1cc(Cl)ccc1-n1cnnn1",
        "output": "431"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN.CCOC(=O)C(C)(C)c1ccc(OC)c(-c2ccc(C(F)(F)F)cc2C=O)c1>>CCNCc1cc(C(F)(F)F)ccc1-c1cc(C(C)(C)C(=O)OCC)ccc1OC",
        "output": "468"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)C=Cc1cccc(N)c1.O=C(O)c1cccc(-c2cc(Cl)cc(Cl)c2)n1>>CCOC(=O)C=Cc1cccc(NC(=O)c2cccc(-c3cc(Cl)cc(Cl)c3)n2)c1",
        "output": "548"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(O[Si](C)(C)C(C)(C)C)[C@@H](CO[Si](C)(C)C(C)(C)C)Nc1c([N+](=O)[O-])cnc2ccccc12.Cc1ccccc1.[Pt]>>CC(C)(O[Si](C)(C)C(C)(C)C)[C@@H](CO[Si](C)(C)C(C)(C)C)Nc1c(N)cnc2ccccc12",
        "output": "269"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=C(C)C(=O)Nc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nnnn3C(c3ccccc3)(c3ccccc3)c3ccccc3)cc2)c1C(=O)OCC.CCO.Cl>>C=C(C)C(=O)Nc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c1C(=O)OCC",
        "output": "815"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N(Cc1cc2c(cn1)OCCO2)C1CCNCC1.CO.ClC(Cl)Cl.O=C([O-])O.O=CCn1c(=O)n[n+]([O-])c2ccc(Cl)cc21.[Na+].[Na+]>>CC(C)(C)OC(=O)N(Cc1cc2c(cn1)OCCO2)C1CCN(CCn2c(=O)n[n+]([O-])c3ccc(Cl)cc32)CC1",
        "output": "484"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(=O)(=O)c1cccc(N)c1.Cl.O=C(O)c1cnn2c(C(F)(F)F)cc(-c3ccc(Cl)cc3)nc12>>CS(=O)(=O)c1cccc(NC(=O)c2cnn3c(C(F)(F)F)cc(-c4ccc(Cl)cc4)nc23)c1",
        "output": "969"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOc1ccc(B(O)O)cc1.COc1ccc2c(Cl)nc(Nc3cc(C)[nH]n3)cc2c1>>CCOc1ccc(-c2nc(Nc3cc(C)[nH]n3)cc3cc(OC)ccc23)cc1",
        "output": "865"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1cc(NC(=O)CSSCCNC(=O)OC(C)(C)C)ccc1O.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1cc(NC(=O)CSSCCN)ccc1O",
        "output": "538"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C#N)c1cccc(C(=O)Cl)c1.CN(C)c1ccncc1.Cc1ccc(N)cc1[N+](=O)[O-].Cl.c1ccncc1>>Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1[N+](=O)[O-]",
        "output": "11"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(Cn2nc(-c3ccc(Cl)cc3)n(CC(O)C(F)(F)F)c2=O)cc1.O.[Na+].[OH-]>>O=C(O)c1ccc(Cn2nc(-c3ccc(Cl)cc3)n(CC(O)C(F)(F)F)c2=O)cc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN.COc1ccc(C(=O)O)cc1/C=C/c1ccc(Cl)cc1.Cl>>CNC(=O)c1ccc(OC)c(/C=C/c2ccc(Cl)cc2)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCNC1CCC2(CC1)OCCO2.O=C(Cl)OCc1ccccc1>>CCN(C(=O)OCc1ccccc1)C1CCC2(CC1)OCCO2",
        "output": "427"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C(=O)c1cn(-c2ccc(C#N)cc2Cl)c2ccccc12.CCO.CS(C)=O.OO.[K+].[OH-]>>CC(C)C(=O)c1cn(-c2ccc(C(N)=O)cc2Cl)c2ccccc12",
        "output": "180"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C(=O)Cl.Cc1cc(-c2nc3ccccc3c(=O)n2-c2ccc(N)cc2)cc(C)c1OCCO.ClCCl>>Cc1cc(-c2nc3ccccc3c(=O)n2-c2ccc(NC(=O)C(C)C)cc2)cc(C)c1OCCO",
        "output": "9"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COc1cc(NC(=O)CCCCCN2CCN(c3ccccn3)CC2)c2nccc(C)c2c1.O.[Al+3].[Al+3].[Cl-].[Cl-].[Cl-].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>COc1cc(NCCCCCCN2CCN(c3ccccn3)CC2)c2nccc(C)c2c1",
        "output": "112"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.C[C@H](c1cccc2ccccc12)N(CC1CNC(=O)CO1)C(=O)OC(C)(C)C.I[Cu]I.Ic1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>C[C@H](c1cccc2ccccc12)N(CC1CN(c2ccccc2)C(=O)CO1)C(=O)OC(C)(C)C",
        "output": "921"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCCCCCCCCCCCCOCC(CS(=O)(=O)CCCCO)OC.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CCCCCCCCCCCCCCCCCCOCC(CS(=O)(=O)CCCCOS(C)(=O)=O)OC",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "NC12CC3CC(CC(C3)C1O)C2.O=Cc1cc2ccsc2s1>>OC1C2CC3CC(C2)CC1(NCc1cc2ccsc2s1)C3",
        "output": "691"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.COC(=O)c1ccccc1OS(C)(=O)=O.Cl>>CS(=O)(=O)Oc1ccccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#CCBr.CC(C)=O.Cc1ccccc1.Cc1nnc(Cl)c2ccc(O)cc12.O=C([O-])[O-].[K+].[K+]>>C#CCOc1ccc2c(Cl)nnc(C)c2c1",
        "output": "154"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCc1cc(C(=O)OCC)nn1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1F.CO.[Li+].[OH-]>>CCCc1cc(C(=O)O)nn1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1F",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.C[C@H](CN)Oc1cc(NS(=O)(=O)N2CCC2)nc(SCc2cccc(F)c2F)n1.ClCCl.c1ccncc1>>CC(=O)NC[C@@H](C)Oc1cc(NS(=O)(=O)N2CCC2)nc(SCc2cccc(F)c2F)n1",
        "output": "339"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC1)CN(c1ncccn1)CC(CO)O2.CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCC2CN(c3ncccn3)CC3(CCN(C(=O)OC(C)(C)C)CC3)O2)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCN1CC(=O)N(C(O)C#N)C1=O.CC(C)C(Nc1ccc(C(F)(F)F)cc1F)C(=O)O.CCN(CC)CC.CCOCC>>C#CCN1CC(=O)N(C(C#N)OC(=O)C(Nc2ccc(C(F)(F)F)cc2F)C(C)C)C1=O",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cc1nc(C(=O)O)ccc1[N+](=O)[O-].O=S(Cl)Cl>>COC(=O)c1ccc([N+](=O)[O-])c(C)n1",
        "output": "331"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)CCCNc1ncc(C#Cc2cccc(NC(=O)Oc3ccccc3)c2)cn1.Nc1ccccc1>>CN(C)CCCNc1ncc(C#Cc2cccc(NC(=O)Nc3ccccc3)c2)cn1",
        "output": "948"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.OC[C@H]1CC[C@H](O)C1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OC[C@H]1CC[C@H](O)C1",
        "output": "193"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(O)c1cc(C(=O)O)no1.C[C@H](N)Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1>>CC(O)c1cc(C(=O)N[C@@H](C)Cn2ccc(-c3ccc(C#N)c(Cl)c3)n2)no1",
        "output": "696"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCOC(=O)Cn1nnc(-c2cnc(N3CCNCC3)nc2)n1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O.O=C(O)c1ccccc1C(F)(F)F>>CCOC(=O)Cn1nnc(-c2cnc(N3CCN(C(=O)c4ccccc4C(F)(F)F)CC3)nc2)n1",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(Oc2ccccc2C(=O)O)cc1.ClP(Cl)Cl.N.c1ccccc1>>Cc1ccc(Oc2ccccc2C(N)=O)cc1",
        "output": "358"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNCC1.ClCC1CO1.Oc1ccc2c(c1)OCC(c1ccccc1)C2>>c1ccc(C2COc3cc(OCC4CO4)ccc3C2)cc1",
        "output": "15"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)C(C)(C)COCCOCCOCc1ccccc1.CCO.[Pd]>>CC(C)(C)OC(=O)C(C)(C)COCCOCCO",
        "output": "178"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cn1cncc1Br.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].OB(O)c1cccc(B(O)O)c1.[K+].[K+].[K+].[Pd].[Pd]>>Cn1cncc1-c1cccc(B(O)O)c1",
        "output": "876"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CO.CS(C)=O.F[P-](F)(F)(F)(F)F.O=C(O)c1cccc2[nH]c(-c3n[nH]c4ncc(-c5cncc6ccccc56)cc34)nc12>>CC(C)NC(=O)c1cccc2[nH]c(-c3n[nH]c4ncc(-c5cncc6ccccc56)cc34)nc12",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COc1ccc(C(=O)O)cc1O.O=S(Cl)Cl>>COC(=O)c1ccc(OC)c(O)c1",
        "output": "33"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Cc1nc2cc(C3=CCC(C(C)(C)C)CC3)c([N+](=O)[O-])cc2s1.[Pd]>>Cc1nc2cc(C3=CCC(C(C)(C)C)CC3)c(N)cc2s1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCc1ccccc1.CN(C)C=O.O.O=C(O)c1cc(O)cc(Br)c1.O=C([O-])[O-].[K+].[K+]>>O=C(OCc1ccccc1)c1cc(O)cc(Br)c1",
        "output": "403"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOc1ccc(S(=O)(=O)N(Cc2ccc(C(=O)O)cc2)Cc2ccccn2)cc1.N[C@@H](CO)[C@@H](O)c1ccccc1>>CCOc1ccc(S(=O)(=O)N(Cc2ccc(C(=O)N[C@@H](CO)[C@@H](O)c3ccccc3)cc2)Cc2ccccn2)cc1",
        "output": "821"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cccc(S(=O)(=O)Cc2nc(-c3ccc(C(=O)O)cc3)oc2C)c1.NCc1cccnc1.O=C(Cl)C(=O)Cl>>Cc1cccc(S(=O)(=O)Cc2nc(-c3ccc(C(=O)NCc4cccnc4)cc3)oc2C)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)C(Oc1cc2c(cc1OC)ncc1c2c(-c2ccc(C#N)cc2)nn1C)c1ccc(F)cc1.Cl.O.[Na+].[OH-]>>COc1cc2ncc3c(c(-c4ccc(C#N)cc4)nn3C)c2cc1OC(C(=O)O)c1ccc(F)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.COC(=O)c1ccc(COc2cccc3c2C(Cc2cc(OC)cc(OC)c2)=CC3)cc1.COc1cc(CC2CCc3cccc(CCc4ccc(C(=O)O)cc4)c32)cc(OC)c1.[Pd]>>COC(=O)c1ccc(COc2cccc3c2C(Cc2cc(OC)cc(OC)c2)CC3)cc1",
        "output": "249"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCC(=O)Cl.Cc1[nH]c2c(-c3ccc(F)cc3OCC3CC3)ccnc2c1C(=O)N[C@@H]1CC[C@@H](N)CC1>>COCC(=O)N[C@@H]1CC[C@@H](NC(=O)c2c(C)[nH]c3c(-c4ccc(F)cc4OCC4CC4)ccnc23)CC1",
        "output": "45"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CCO.CCOC(=O)C(C)(C)c1cccc(C=O)c1.Cl.NO.[Na+]>>CCOC(=O)C(C)(C)c1cccc(C#N)c1",
        "output": "453"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCCSc1cccs1.CCOC(C)=O.CN(C)C=O.Cl.NC1CCN(C(=O)C(F)(F)F)CC1.O.O=C([O-])[O-].[K+].[K+]>>O=C(N1CCC(NCCSc2cccs2)CC1)C(F)(F)F",
        "output": "147"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCC.CI.CN(C)C=O.O=C(O)C1(c2ccccc2)CC1.O=C([O-])[O-].[K+].[K+]>>COC(=O)C1(c2ccccc2)CC1",
        "output": "415"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCc1nc(-c2cccc(C)c2)c(-c2ccnc(F)c2)s1.NC1CCCC1.O=C([O-])O.[Na+]>>CCc1nc(-c2cccc(C)c2)c(-c2ccnc(NC3CCCC3)c2)s1",
        "output": "810"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Cc1ccc(C)c(O)c1.N#Cc1ccc(Cl)c([N+](=O)[O-])c1.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(C)c(Oc2ccc(C#N)cc2[N+](=O)[O-])c1",
        "output": "299"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O.Clc1nc(Cl)nc(Cl)n1.OC[C@H]1CC1(F)F>>FC1(F)C[C@@H]1COc1nc(Cl)nc(Cl)n1",
        "output": "213"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.C[O-].Clc1cc(Cl)ncn1.O.[Na+]>>COc1cc(Cl)ncn1",
        "output": "653"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.C[C@H](N)c1nc2ccc(F)c(C#N)c2n1-c1ccccn1.Cc1nc(N)nc(Cl)c1C#N>>Cc1nc(N)nc(N[C@@H](C)c2nc3ccc(F)c(C#N)c3n2-c2ccccn2)c1C#N",
        "output": "110"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.CCOC(=O)CCc1cccc(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)c1C(F)(F)F.Cl.O.[Na+].[OH-]>>CC(C)Oc1ccc(-c2nc(-c3cccc(CCC(=O)O)c3C(F)(F)F)no2)cc1C#N",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCN1.C1COCCO1.Cc1nc(S(C)(=O)=O)ncc1-c1cc(Cl)ccc1OCC(=O)OC(C)(C)C>>Cc1nc(N2CCOCC2)ncc1-c1cc(Cl)ccc1OCC(=O)OC(C)(C)C",
        "output": "679"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(F)cc2C(F)(F)F)CN1c1cc(C)nn1C1CCC1.[Li+].[OH-]>>Cc1cc(N2C[C@H](S(=O)(=O)c3ccc(F)cc3C(F)(F)F)C[C@H]2C(=O)O)n(C2CCC2)n1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C(=O)CN1CCc2ccc(N)cc2CC1.CS(=O)(=O)N[C@@H]1CCCC[C@H]1Nc1nc(Cl)ncc1Cl>>CN(C)C(=O)CN1CCc2ccc(Nc3ncc(Cl)c(N[C@@H]4CCCC[C@H]4NS(C)(=O)=O)n3)cc2CC1",
        "output": "808"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)c1c(C#N)cc(N[C@@H]2CCCC[C@@H]2NC(=O)OC(C)(C)C)nc1Nc1ccc2cn[nH]c2c1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1c(C#N)cc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1ccc2cn[nH]c2c1",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)NC1CCNC1.CCOC(=O)CC(=O)c1cc(F)c(Cl)nc1Cl>>CCOC(=O)CC(=O)c1cc(F)c(N2CCC(NC(C)=O)C2)nc1Cl",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(Cl)cc1B(O)O.N#Cc1cccc(I)c1>>COc1ccc(Cl)cc1-c1cccc(C#N)c1",
        "output": "855"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CON.Cl.O=C(Cc1ccc(F)cc1)c1ccccc1.c1ccncc1>>CON=C(Cc1ccc(F)cc1)c1ccccc1",
        "output": "212"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.O=C([O-])O.O=Cc1ccc(Cl)nc1.[Na+].[Na+].c1ccc([C@H]2CNCCO2)cc1>>Clc1ccc(CN2CCO[C@@H](c3ccccc3)C2)cn1",
        "output": "757"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)Oc1ccc(OCCO[Si](C)(C)C(C)(C)C)cc1.CC1CCCO1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>CC(C)(C)Oc1ccc(OCCO)cc1",
        "output": "708"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1cc(N2CCC(N3CCC[C@H]3C)C2)ccc1N.O=C(Cl)c1ccccc1F>>Cc1cc(N2CCC(N3CCC[C@H]3C)C2)ccc1NC(=O)c1ccccc1F",
        "output": "11"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.CN1CCNCC1.Cc1cc(CCC(=O)O)[nH]c1C=O.ClCCCl.O=C([O-])O.On1nnc2ccccc21.[Na+]>>Cc1cc(CCC(=O)N2CCN(C)CC2)[nH]c1C=O",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.CN(C)c1ccncc1.O=C1N[C@H](CO)C[C@H]1CCCCl.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1.O=[N+]([O-])c1ccc(S(=O)(=O)[O-])cc1>>O=C1N[C@H](COS(=O)(=O)c2ccc([N+](=O)[O-])cc2)C[C@H]1CCCCl",
        "output": "197"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NCC3CN(C(=O)OC(C)(C)C)C3)c2)CC1.ClCCl.O=C(O)C(F)(F)F>>CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NCC3CNC3)c2)CC1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)c1[nH]c2cc(Cl)cc(Cl)c2c1NCCC(=O)c1ccccc1F.CCOC(C)=O.O.[Li+].[OH-]>>O=C(CCNc1c(C(=O)O)[nH]c2cc(Cl)cc(Cl)c12)c1ccccc1F",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)CN.O=C(O)Cc1nn(NC(=O)Cc2ccc(Cl)cc2)c(=O)c2ccccc12>>CC(C)(C)CNC(=O)Cc1nn(NC(=O)Cc2ccc(Cl)cc2)c(=O)c2ccccc12",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)OC(=O)Cl.Cc1ccccc1.ClCCl.Fc1cc(-c2ccc3oc(C4CCNCC4)nc3c2)ccc1-n1cnnn1.O.O=C(O)C(F)(F)F>>CC(C)OC(=O)N1CCC(c2nc3cc(-c4ccc(-n5cnnn5)c(F)c4)ccc3o2)CC1",
        "output": "219"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CN1CCCC1.COc1nc(-n2cc(C(=O)O)c(=O)c3cc(F)c(F)c(Cl)c32)c(F)cc1F.Cl.Cl.NC1CNC1>>COc1nc(-n2cc(C(=O)O)c(=O)c3cc(F)c(N4CC(N)C4)c(Cl)c32)c(F)cc1F",
        "output": "676"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NC(C)(C)C(=O)O.CCN(CC)CC.COc1ccc(CCN2C(=O)C3(CCNCC3)N(C)C2c2ccc(C3CC3)cc2)cc1.ClC(Cl)Cl.O=C(O)C(F)(F)F.On1nnc2ccccc21>>COc1ccc(CCN2C(=O)C3(CCN(C(=O)C(C)(C)NC(=O)OC(C)(C)C)CC3)N(C)C2c2ccc(C3CC3)cc2)cc1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN1CC(C)(C)OC(=O)C1CC(=O)O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.c1ccc(N2CCNCC2)cc1>>CCN1CC(C)(C)OC(=O)C1CC(=O)N1CCN(c2ccccc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1=COCCC1.CC(=O)OC(C)=O.CCCc1c(OCCCSc2ccc(C(=O)CCC(=O)O)cc2)ccc(C(C)=O)c1O.CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O>>CCCc1c(OCCCSc2ccc(C(=O)CCC(=O)O)cc2)ccc(C(C)=O)c1OC(C)=O",
        "output": "46"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(Sc2ccc(C)cc2[N+](=O)[O-])cc1.Cl[Sn]Cl>>COc1ccc(Sc2ccc(C)cc2N)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CS(C)=O.O=[N+]([O-])c1cc(Br)ccc1F>>O=[N+]([O-])c1cc(Br)ccc1N1CCOCC1",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CCCC1=O.CN1CCNCC1.O=[N+]([O-])c1ccc(Br)cc1Nc1ccccc1>>CN1CCN(c2ccc([N+](=O)[O-])c(Nc3ccccc3)c2)CC1",
        "output": "294"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.O=C([O-])O.O=S([O-])([O-])=S.O=[N+]([O-])c1cccc(CCCO)c1.[Na+].[Na+].[Na+]>>O=CCCc1cccc([N+](=O)[O-])c1",
        "output": "142"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)c1sc(-c2ccccc2)cc1N(Cc1cccc(I)c1)S(=O)(=O)c1cc(C)c(Cl)cc1C.O.O.[Li]O>>Cc1cc(S(=O)(=O)N(Cc2cccc(I)c2)c2cc(-c3ccccc3)sc2C(=O)O)c(C)cc1Cl",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N(Cc1cc2c(cn1)OCCO2)C1CCNCC1.ClC(Cl)Cl.O=C([O-])O.O=CCn1c(=O)ccc2ncc(Br)cc21.[Na+].[Na+]>>CC(C)(C)OC(=O)N(Cc1cc2c(cn1)OCCO2)C1CCN(CCn2c(=O)ccc3ncc(Br)cc32)CC1",
        "output": "484"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CCCC1(C2CCCC2)CC(=O)CC(=O)O1.C#CCCC1(C2CCCC2)CC(OCC)=CC(=O)O1.Ic1ccccc1.Oc1cccc(I)c1>>CCOC1=CC(=O)OC(CCC#Cc2cccc(O)c2)(C2CCCC2)C1",
        "output": "664"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)c1ccncc1.COC(=O)[C@@]12C[C@H]1C=CCCCCN(C)C(=O)[C@@H]1CC[C@@H](O)C[C@H]1C(=O)N2.ClCCl.O=S(=O)(Cl)c1ccc(Br)cc1>>COC(=O)[C@@]12C[C@H]1C=CCCCCN(C)C(=O)[C@@H]1CC[C@@H](OS(=O)(=O)c3ccc(Br)cc3)C[C@H]1C(=O)N2",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCC.Cc1cc(N)nn1Cc1cc(Cl)ccc1OCc1ccccc1.ClCCl.O=C(Cl)Oc1ccccc1.c1ccncc1>>Cc1cc(NC(=O)Oc2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1",
        "output": "700"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCC(CC)COc1ccc(OCC(CC)CCCC)cc1.ClC(Cl)Cl.O.O=[N+]([O-])O>>CCCCC(CC)COc1ccc(OCC(CC)CCCC)c([N+](=O)[O-])c1",
        "output": "21"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.OC1CCc2cccnc21.[Mn+4].[O-2].[O-2]>>O=C1CCc2cccnc21",
        "output": "456"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1cc(Cl)c(OC(C(=O)OCC)c2ccccc2)c(Cl)c1.CCO.[Na+].[OH-]>>CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)[C@@H](Nc1cccnc1)C(=O)O.CC1(C)CNCC[C@]1(O)c1ccc(Cl)cc1.CCN(C(C)C)C(C)C.CN(C)C=O.ClCCCl.On1nnc2ccccc21>>CC(C)[C@@H](Nc1cccnc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)CCC1(C(C)C)Cc2cc(OCC(=O)O)c(Cl)c(Cl)c2C1=O.Cl.O.[BH4-].[K+]>>CC(O)CCC1(C(C)C)Cc2cc(OCC(=O)O)c(Cl)c(Cl)c2C1=O",
        "output": "91"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cc1ccc(S(=O)(=O)OCC(O)CF)cc1.O=C(OCc1ccccc1)N1CCNCC1>>O=C(OCc1ccccc1)N1CCN(CC(O)CF)CC1",
        "output": "429"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(C)=O.Fc1ccc(C(F)(F)F)cc1Cl.O.O=C(O)c1cc(O)ccc1O.O=C([O-])[O-].[K+].[K+]>>O=C(O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1O",
        "output": "564"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(F)ccc1[N+](=O)[O-].O=C([O-])[O-].Oc1ccccc1.[Cu].[K+].[K+]>>Cc1cc(Oc2ccccc2)ccc1[N+](=O)[O-]",
        "output": "564"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[O-].CC(=O)c1ccc2c(c1)CCc1c(O)cc(O)cc1S2.CCO.Cl.NO.O.[Na+]>>CC(=NO)c1ccc2c(c1)CCc1c(O)cc(O)cc1S2",
        "output": "212"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[C@H](O)CCN.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cc1cc(N2CCOCC2)cc(C2CC2)c1C(=O)O.ClCCl.O.Oc1cccc2[nH]nnc12>>Cc1cc(N2CCOCC2)cc(C2CC2)c1C(=O)NCC[C@@H](O)C(C)(C)C",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#CCOc1ccc2c(C)cc(=O)oc2c1C(C)=O.CCO.O.O=Cc1ccccc1.[K+].[OH-]>>C#CCOc1ccc2c(C)cc(=O)oc2c1C(=O)C=Cc1ccccc1",
        "output": "295"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(N)C(=O)O.CCCC(=O)Cl.CCN(CC)CC.C[Si](C)(C)Cl.ClCCl.O.[Na+].[OH-]>>CCCC(=O)NC(CC)C(=O)O",
        "output": "585"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CN.COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2C=O)c1.ClCCl.O=C([O-])O.[BH3-]C#N.[Na+].[Na+]>>CNCc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)OC)ccc1OC",
        "output": "468"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#Cc1ccc(CO)cc1.C1CCOC1.CC(C)NC(C)C.CCOC(C)=O.Cl.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Oc1ccc(Br)cc1.[Cu]I>>OCc1ccc(C#Cc2ccc(O)cc2)cc1",
        "output": "659"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COCCOCOc1c(C/C=C(\\C)CCC(=O)OC)c(OC)c(C)c2c1C(=O)OC2.O.[Na+].[OH-]>>COCCOCOc1c(C/C=C(\\C)CCC(=O)O)c(OC)c(C)c2c1C(=O)OC2",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.C[C@H](Nc1nc(Nc2cc(C3CC3)[nH]n2)c(F)cc1C=O)c1ccc(F)cc1.[BH4-].[Na+]>>C[C@H](Nc1nc(Nc2cc(C3CC3)[nH]n2)c(F)cc1CO)c1ccc(F)cc1",
        "output": "476"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCP(=O)=O.CCN(C(C)C)C(C)C.CCc1cccc(N)c1.CN(C)c1ccncc1.ClCCCl.O=C(O)c1cccc(N2CCc3c(cnc4ccsc34)C2)c1>>CCc1cccc(NC(=O)c2cccc(N3CCc4c(cnc5ccsc45)C3)c2)c1",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)Cn1cc(-c2ccc(N3CCC(N4CCc5ccc(F)cc54)CC3)nn2)cn1.ClCCl.O.[BH4-].[Na+]>>OCCn1cc(-c2ccc(N3CCC(N4CCc5ccc(F)cc54)CC3)nn2)cn1",
        "output": "225"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1ccc(I)cc1.CN(C)C=O.O=C([O-])[O-].[Cu].[K+].[K+].c1ccc2c(c1)[nH]c1ccccc12>>Brc1ccc(-n2c3ccccc3c3ccccc32)cc1",
        "output": "267"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "FC(F)C(F)(F)Oc1ccc(-c2cc(CCl)on2)cc1.Fc1cccc(-c2nc3cn[nH]cc-3n2)c1F>>Fc1cccc(-c2nc3cnn(Cc4cc(-c5ccc(OC(F)(F)C(F)F)cc5)no4)cc-3n2)c1F",
        "output": "997"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)c1csc2ccccc12.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.O.[Br-].[Br-].[Br-]>>O=C(CBr)c1csc2ccccc12",
        "output": "360"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCc1ncc(C(C)N(C(=O)OC(C)(C)C)C2CC2)cc1CCCNC(=O)OC.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CCc1ncc(C(C)NC2CC2)cc1CCCNC(=O)OC",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCOc2c(C3CC3)csc2C1.O=C1CCC(=O)N1Br.O=S([O-])([O-])=S.[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCOc2c(sc(Br)c2C2CC2)C1",
        "output": "807"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCn1c(=O)c(NC(=O)Nc2c(C(C)C)cccc2C(C)C)c(-c2cccc(O)c2)c2cccnc21.CCCI.CN(C)C=O.O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CCCCn1c(=O)c(NC(=O)Nc2c(C(C)C)cccc2C(C)C)c(-c2cccc(OCCC)c2)c2cccnc21",
        "output": "198"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cn1nc(NS(C)(=O)=O)c2c(Cl)ccc(-c3ccc(C#CC4(CO[Si](C)(C)C(C)(C)C)CCCC4)nc3[C@H](Cc3cc(F)cc(F)c3)NC(=O)Cn3nc(C(F)(F)F)c4c3C(F)(F)[C@@H]3C[C@H]43)c21.[F-]>>Cn1nc(NS(C)(=O)=O)c2c(Cl)ccc(-c3ccc(C#CC4(CO)CCCC4)nc3[C@H](Cc3cc(F)cc(F)c3)NC(=O)Cn3nc(C(F)(F)F)c4c3C(F)(F)[C@@H]3C[C@H]43)c21",
        "output": "708"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COCCCl.Cc1ccccc1.O.Oc1cccc2ccccc12.[I-].[Na+].[Na+].[OH-]>>COCCOc1cccc2ccccc12",
        "output": "74"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COB(OC)OC.Cc1ccc(C)c(Br)c1.Cc1ccc(C)c(Br)c1.II.O=S(=O)(O)O.[Mg]>>Cc1ccc(C)c(B(O)O)c1",
        "output": "789"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1oc2ccc(F)cc2c1-c1ccccc1Cl.O.[K+].[OH-]>>O=C(O)c1oc2ccc(F)cc2c1-c1ccccc1Cl",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(O)CN.CCOC(C)=O>>CC(O)CNC(=O)OC(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCNCC.O=C(Cl)c1ccccc1Cl>>CCN(CC)C(=O)c1ccccc1Cl",
        "output": "201"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OC1CCN(C2CCCC2)CC1>>CS(=O)(=O)OC1CCN(C2CCCC2)CC1",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCNCC.ClCCl.O=C(Cl)C(Br)c1ccccc1>>CCN(CC)C(=O)C(Br)c1ccccc1",
        "output": "125"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](C)(C)OCc1cccnc1-c1ccnn1CCC(F)(F)F.CO.Cl>>OCc1cccnc1-c1ccnn1CCC(F)(F)F",
        "output": "708"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.CN(C)C=O.O.O=C([O-])[O-].Oc1ccc(Br)cc1F.[K+].[K+]>>Fc1cc(Br)ccc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-c2ccnc3[nH]c(C4=CCN(S(C)(=O)=O)CC4)cc23)cc1.O.[Li+].[OH-]>>CS(=O)(=O)N1CC=C(c2cc3c(-c4ccc(C(=O)O)cc4)ccnc3[nH]2)CC1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O=C1Nc2cc(-c3ccco3)ccc2C2CCCC12>>S=C1Nc2cc(-c3ccco3)ccc2C2CCCC12",
        "output": "695"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cc2ccccc2n1S(=O)(=O)c1ccc(Br)cc1.CCOC(C)=O.CO.Cc1ccccc1.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].O=S(=O)([O-])[O-].[H-].[Na+].[Na+].[Na+].[Na+]>>O=S(=O)(c1ccc(Br)cc1)n1c(CO)cc2ccccc21",
        "output": "711"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.ClCCl.Clc1cccc(N2CCNCC2)c1.O=C(Cl)C(=O)Cl.O=C(O)c1sccc1-c1ccccc1>>O=C(c1sccc1-c1ccccc1)N1CCN(c2cccc(Cl)c2)CC1",
        "output": "857"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC1(C)C=Cc2cc(CC(=O)O)ccc2O1.NC1CCCc2ccccc21>>CC1(C)C=Cc2cc(CC(=O)NC3CCCc4ccccc43)ccc2O1",
        "output": "599"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCCCCCCBr.CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccccc1.O.OCCOCc1c(Cl)cccc1Cl.[Br-].[Na+].[OH-]>>Clc1cccc(Cl)c1COCCOCCCCCCBr",
        "output": "95"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.O=C(Cc1ccccc1)c1cccc(O)c1.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c(Cl)c1.[K+].[K+]>>O=C(Cc1ccccc1)c1cccc(Oc2ccc([N+](=O)[O-])cc2Cl)c1",
        "output": "564"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.COC(=O)c1cc(C#N)ccc1C1C2=C(CCNC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1C.Cl.O.[Li+].[OH-]>>CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)NCC2)C1c1ccc(C#N)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)c1cc(Cl)c(F)c(-c2cncc(S(C)(=O)=O)c2)c1O.CC(C)OC(=O)N=NC(=O)OC(C)C.CCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOc1c(C(C)=O)cc(Cl)c(F)c1-c1cncc(S(C)(=O)=O)c1",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1ccc(CO)cc1.ClC(Cl)Cl.O=S(Cl)Cl>>CCCc1ccc(CCl)cc1",
        "output": "81"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)CC1CCC(c2ccc(-c3ccc(Nc4ccc(C(F)(F)F)nc4)cn3)cc2)CC1.Cl.[Li+].[OH-]>>O=C(O)CC1CCC(c2ccc(-c3ccc(Nc4ccc(C(F)(F)F)nc4)cn3)cc2)CC1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1=COCCC1.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.Oc1cc(Br)cc(F)c1F.c1cc[nH+]cc1>>Fc1cc(Br)cc(OC2CCCCO2)c1F",
        "output": "319"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1C(=O)CCc2ccc(N)cc21.O.O=C(Cl)c1ccc(C(F)(F)F)cc1F.c1ccncc1>>CN1C(=O)CCc2ccc(NC(=O)c3ccc(C(F)(F)F)cc3F)cc21",
        "output": "11"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CNCCN(C)C.O=C(O)c1ccc(N(CCO)C(=O)c2cc3c(s2)-c2ccccc2OCC3)c(Cl)c1>>CN(C)CCN(C)C(=O)c1ccc(N(CCO)C(=O)c2cc3c(s2)-c2ccccc2OCC3)c(Cl)c1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)CC(C(=O)O)N1C(=O)C(=O)c2c(Cl)cccc21.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.Nc1nccs1>>CC(C)CC(C(=O)Nc1nccs1)N1C(=O)C(=O)c2c(Cl)cccc21",
        "output": "681"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)ccc1O.Cl.O.[Na+].[OH-]>>Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1ccc(O)c(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)c1cccc(CN2CN(c3ccccc3)C3(CCN(CCCn4ncc5ccccc54)CC3)C2=O)c1.Cl>>O=C(O)c1cccc(CN2CN(c3ccccc3)C3(CCN(CCCn4ncc5ccccc54)CC3)C2=O)c1",
        "output": "752"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CC(=O)O)Cc1cc(F)c(F)cc1F.CC1NCCc2ccnnc21.CCN(C(C)C)C(C)C.CN(C)C(Oc1ccnc2[nH]nnc12)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)C(F)(F)F.On1nnc2cccnc21>>CC1c2nnccc2CCN1C(=O)C[C@@H](Cc1cc(F)c(F)cc1F)NC(=O)OC(C)(C)C",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.O=C(OO)c1cccc(Cl)c1.Oc1ccc(SCC2COC(c3ccccc3)=N2)cc1>>O=S(CC1COC(c2ccccc2)=N1)c1ccc(O)cc1",
        "output": "500"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1ccc2ccccc2n1.C#Cc1cn2c(Br)cnc(N3CCOCC3)c2n1.CCN(C(C)C)C(C)C.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O.[Cu]I>>Brc1cnc(N2CCOCC2)c2nc(C#Cc3ccc4ccccc4n3)cn12",
        "output": "777"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCCNC1.CCCCO.CCN(C(C)C)C(C)C.O=[N+]([O-])c1cnccc1Cl>>CC(C)(C)OC(=O)N[C@H]1CCCN(c2ccncc2[N+](=O)[O-])C1",
        "output": "398"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)COC(c2ccc(OCCC3CCN(Cc4ccccc4)CC3)cc2)=N1.CO.[H][H].[Pd]>>CC1(C)COC(c2ccc(OCCC3CCNCC3)cc2)=N1",
        "output": "84"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)CC1.CCOC(C)=O.CN(C)C=O.COCCBr.[H-].[Na+]>>COCCOC1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "95"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCC1(OC)CCNCC1.CCOC(=O)c1ccc(F)cc1.CCOC(C)=O.CS(C)=O.O.O=C(O)C(F)(F)F.O=C([O-])[O-].[K+].[K+]>>CCCCC1(OC)CCN(c2ccc(C(=O)OCC)cc2)CC1",
        "output": "773"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCc1ccc(OC)cc1.ClCCl>>C=CCc1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].Nc1c(F)cccc1F.O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>Nc1c(F)cc(Br)cc1F",
        "output": "98"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCNCc1cc(-c2cnn(C)c2)ccc1-c1cc(CC(=O)OCC)ccc1OC.O=C(Cl)C1CC1>>CCOC(=O)Cc1ccc(OC)c(-c2ccc(-c3cnn(C)c3)cc2CN(CC)C(=O)C2CC2)c1",
        "output": "240"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)C=Cc1c(Cc2ccccc2C(F)(F)F)sc2c1c(=O)n(C)c(=O)n2CC(C)C.O.O.[Li+].[OH-]>>CC(C)Cn1c(=O)n(C)c(=O)c2c(C=CC(=O)O)c(Cc3ccccc3C(F)(F)F)sc21",
        "output": "58"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCCc2ccc(CO)cc2C1.O=C(O)C1CCN(c2ccncc2)CC1>>CC(C)(C)OC(=O)N1CCCc2ccc(COC(=O)C3CCN(c4ccncc4)CC3)cc2C1",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Clc1nc2ccccc2[nH]1.Nc1ccc(F)c(F)c1F>>Fc1ccc(Nc2nc3ccccc3[nH]2)c(F)c1F",
        "output": "808"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN.C[C@H](Oc1cc(C(=O)NC(C)(CC(=O)O)C2CC2)ncc1C1CC1)C(F)(F)F.Cl>>CNC(=O)CC(C)(NC(=O)c1cc(O[C@@H](C)C(F)(F)F)c(C2CC2)cn1)C1CC1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cnccn2)CC1.ClC(Cl)Cl.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1CCN(c2cnc(Br)cn2)CC1",
        "output": "665"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCCCO.CCOC(C)=O.Oc1ccnc(Cl)c1>>CC(C)(C)OC(=O)N1CCN(c2cc(O)ccn2)CC1",
        "output": "220"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCOC(=O)C1(NS(=O)(=O)c2ccc(OCc3cc(C)nc4ccccc34)cc2)CCN(C(C)=O)CC1.Cl>>CC(=O)N1CCC(NS(=O)(=O)c2ccc(OCc3cc(C)nc4ccccc34)cc2)(C(=O)O)CC1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COc1ccc(CC(C)NCC(O)c2ccccc2OCc2ccccc2)cc1.O=C(O)C(=O)O.[C].[Pd]>>COc1ccc(CC(C)NCC(O)c2ccccc2O)cc1",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.CCN(CC)CC.CN(C)c1cc2c(cc1Cl)NCC(C(=O)N1CCC(C#N)(Cc3ccc(F)cc3)CC1)O2.ClCCl>>CC(=O)N1CC(C(=O)N2CCC(C#N)(Cc3ccc(F)cc3)CC2)Oc2cc(N(C)C)c(Cl)cc21",
        "output": "160"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1cc(F)ccc1-c1nc(S(C)(=O)=O)nc2c1ccc(=O)n2-c1c(F)cccc1F.NCCc1c[nH]cn1>>Cc1cc(F)ccc1-c1nc(NCCc2c[nH]cn2)nc2c1ccc(=O)n2-c1c(F)cccc1F",
        "output": "629"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCC1CC1.CN(C)C=O.COc1ccc(C=O)cc1O.O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(C=O)cc1OCC1CC1",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(CC)CC.ClCCl.O=[N+]([O-])c1ccc(CCl)cc1>>CC(C)(C)OC(=O)N1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1",
        "output": "156"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].COC(=O)c1cc(Br)nc2c1[nH]c1cc(OCCN3CCOCC3)ccc12.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.O=P([O-])([O-])[O-].OB(O)c1cccc(C(F)(F)F)c1.[K+].[K+].[K+].[Pd+2]>>COC(=O)c1cc(-c2cccc(C(F)(F)F)c2)nc2c1[nH]c1cc(OCCN3CCOCC3)ccc12",
        "output": "869"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClC(Cl)Cl.NCCSC(c1ccccc1)(c1ccccc1)c1ccccc1.O=C(Cl)CCl>>O=C(CCl)NCCSC(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "45"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)CN1CCC(Oc2ccccc2OC)CC1.NCC12CC3CC(CC(C3)C1)C2>>COc1ccccc1OC1CCN(CC(=O)NCC23CC4CC(CC(C4)C2)C3)CC1",
        "output": "64"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.COC(=O)C1CNCCC1=O.ClCCl>>COC(=O)C1CN(C(=O)OC(C)(C)C)CCC1=O",
        "output": "694"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(=O)(=O)c1nccc(Oc2ccc(NC(=O)c3cc(F)cc(N4CCOCC4)c3)c3ccccc23)n1.NC1CCCC1>>O=C(Nc1ccc(Oc2ccnc(NC3CCCC3)n2)c2ccccc12)c1cc(F)cc(N2CCOCC2)c1",
        "output": "629"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)O.Cc1ccc(N2CCNCC2)cc1C.F[P-](F)(F)(F)(F)F>>Cc1ccc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc1C",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)COC(=O)Cl.Nc1cccnc1.O.[Na+].[OH-]>>CC(C)COC(=O)Nc1cccnc1",
        "output": "763"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)CCc1ccc(N(Cc2cccc(-c3c(C)cc(OCC4(O)CCSCC4)cc3C)c2)S(=O)(=O)c2ccccc2[N+](=O)[O-])cc1F.CCOC(C)=O.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)CCc1ccc(N(Cc2cccc(-c3c(C)cc(OCC4(O)CCS(=O)CC4)cc3C)c2)S(=O)(=O)c2ccccc2[N+](=O)[O-])cc1F",
        "output": "13"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COC(=O)Cl.OC12CC3CC(C1)CC(O)(C3)C2.c1ccncc1>>COC(=O)OC12CC3CC(CC(O)(C3)C1)C2",
        "output": "144"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Nc1ccc(N)cc1.CC(CF)(CF)c1cc(NC(=O)Oc2ccccc2)no1.CCN(C(C)C)C(C)C.CN(C)c1ccncc1>>CC(C)(C)OC(=O)Nc1ccc(NC(=O)Nc2cc(C(C)(CF)CF)on2)cc1",
        "output": "948"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)OC(=O)C[C@@H](c1cc(F)cc(F)c1)C1CCN(C(=O)OCc2ccccc2)CC1.CCO.[OH-].[OH-].[Pd+2]>>CC(C)OC(=O)C[C@@H](c1cc(F)cc(F)c1)C1CCNCC1",
        "output": "428"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1[NH2+]CC12COC2.C1[NH2+]CC12COC2.Cc1onc(-c2ccc(F)cc2)c1COc1cc(C(=O)O)n(C)n1.O=C([O-])C(=O)[O-]>>Cc1onc(-c2ccc(F)cc2)c1COc1cc(C(=O)N2CC3(COC3)C2)n(C)n1",
        "output": "663"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COC(=O)C(=Cc1ccc(O)cc1)C(=O)OC.O.OCCBr.[H-].[Na+]>>COC(=O)C(=Cc1ccc(OCCO)cc1)C(=O)OC",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(c1ccccc1)N1CCNCC1.CCN(C(C)C)C(C)C.CN(C)C=O.FC(F)(F)c1nnc2ccc(Cl)nn12>>CC(c1ccccc1)N1CCN(c2ccc3nnc(C(F)(F)F)n3n2)CC1",
        "output": "406"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CNCCN1.CC#N.O=C(CCCCl)c1c[nH]c2ccc(F)cc12.[I-].[K+]>>O=C(CCCN1CCNCC1)c1c[nH]c2ccc(F)cc12",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccncc1.CC#N.CC(C)c1ccc(B(O)O)cc1.Cl.O.O=C([O-])[O-].[Na+].[Na+]>>CC(C)c1ccc(-c2ccncc2)cc1",
        "output": "872"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=O.O=CO.OCC1CCCCN1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CN1CCCCC1CO",
        "output": "217"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)CC(=O)c1cccc(-c2cncnc2)c1.CC(C)(C)OC(=O)Nc1cc(Cl)c(C(F)(F)F)cc1N>>CC(C)(C)OC(=O)Nc1cc(Cl)c(C(F)(F)F)cc1NC(=O)CC(=O)c1cccc(-c2cncnc2)c1",
        "output": "929"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCc1nc(Cl)nc(Cl)n1.CCN(C(C)C)C(C)C.CCOCC.Nc1ccc2cn[nH]c2c1.O>>CCCc1nc(Cl)nc(Nc2ccc3cn[nH]c3c2)n1",
        "output": "592"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(=O)CN1CCC(=Cc2cccc(Br)c2CC)CC1.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)CN1CCC(=Cc2cccc(B3OC(C)(C)C(C)(C)O3)c2CC)CC1",
        "output": "942"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCNCC1.O=C([O-])[O-].O=[N+]([O-])c1cccc([N+](=O)[O-])c1Cl.[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(c2c([N+](=O)[O-])cccc2[N+](=O)[O-])CC1",
        "output": "105"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CS(C)=O.OCC=Cc1c[nH]c(-c2ccc(F)cc2)c1-c1ccncc1.[Mn+2].[O-2]>>O=CC=Cc1c[nH]c(-c2ccc(F)cc2)c1-c1ccncc1",
        "output": "183"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.Cc1ccccc1.O=C(O)c1ccccc1F.O=S(Cl)Cl>>O=C(Cl)c1ccccc1F",
        "output": "3"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "FC(F)(F)c1cccc(C2CCNCC2)c1.Oc1ccc(CCCl)cc1>>Oc1ccc(CCN2CCC(c3cccc(C(F)(F)F)c3)CC2)cc1",
        "output": "138"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O=S(=O)(O)O.O=[N+]([O-])[O-].O=c1[nH]c2c(n3ccnc13)Cc1c(Br)cccc1-2.[K+]>>O=c1[nH]c2c(n3ccnc13)Cc1c-2ccc([N+](=O)[O-])c1Br",
        "output": "103"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)NCCN.Cc1ccc(C(=O)Nc2nccs2)cc1-c1nc(S(C)=O)nc2c1ccc(=O)n2-c1c(F)cccc1F>>Cc1ccc(C(=O)Nc2nccs2)cc1-c1nc(NCCNC(C)C)nc2c1ccc(=O)n2-c1c(F)cccc1F",
        "output": "666"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CCNCC1.Cn1c(=O)n(-c2ccc(Cl)nc2)c2c3cc(-c4cccnc4)ccc3ncc21>>CN1CCN(c2ccc(-n3c(=O)n(C)c4cnc5ccc(-c6cccnc6)cc5c43)cn2)CC1",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOc1c(OC)cccc1C(O)c1cc(Cl)ccc1-n1cccc1.ClCCl.[Mn+4].[O-2].[O-2]>>CCOc1c(OC)cccc1C(=O)c1cc(Cl)ccc1-n1cccc1",
        "output": "59"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(Cl)c(C#N)cc1-c1nccc2cc(S(=O)(=O)Nc3ncns3)ccc12.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.O=P([O-])([O-])[O-].OB(O)c1cccc(F)c1.[K+].[K+].[K+]>>COc1cc(-c2cccc(F)c2)c(C#N)cc1-c1nccc2cc(S(=O)(=O)Nc3ncns3)ccc12",
        "output": "892"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1cccc(CO)c1.O=C(Cl)CCl>>O=C(CCl)Nc1cccc(CO)c1",
        "output": "9"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN(C)C(C)=O)c1=O.C[C@H](N)CO>>CC(=O)N(C)CCn1c(=O)c(C(=O)N[C@@H](C)CO)c(O)c2ncc(Cc3ccc(F)cc3)cc21",
        "output": "498"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1cc2cc(F)c(F)cc2[nH]1.[Na+].[OH-]>>O=C(O)c1cc2cc(F)c(F)cc2[nH]1",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.COCCC[C@H]1CNCCN1C(=O)OC(C)(C)C.Cl.O=C(O)c1cccc2ccccc12.On1nnc2ccccc21>>COCCC[C@H]1CN(C(=O)c2cccc3ccccc23)CCN1C(=O)OC(C)(C)C",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CNC(=O)C(C)(C)N.O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1>>CNC(=O)C(C)(C)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1",
        "output": "738"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1C(=O)C(NC(=O)[C@@H](N)C(C)(C)C)N=C(c2ccccc2)c2ccccc21.O=C(O)Cc1cc(F)cc(F)c1>>CN1C(=O)C(NC(=O)[C@@H](NC(=O)Cc2cc(F)cc(F)c2)C(C)(C)C)N=C(c2ccccc2)c2ccccc21",
        "output": "133"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[O-].CC(C)O.CC(C)OC(=O)c1cc(-c2cnn(C)c2)nc(Cl)c1Cl.O.[K+]>>CC(C)OC(=O)c1cc(-c2cnn(C)c2)nc(OC(C)C)c1Cl",
        "output": "433"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CC[C@@H](NC(=O)OC(C)(C)C)C(=O)O.CCc1noc2cccc(Oc3ccc(N)cn3)c12.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F>>CCc1noc2cccc(Oc3ccc(NC(=O)[C@@H](CC)NC(=O)OC(C)(C)C)cn3)c12",
        "output": "724"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CC1(C)CCC(=O)CC1O.ClCCl.c1c[nH]cn1>>CC1(C)CCC(=O)CC1O[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)NC(=O)c1cccc(CN2CCN(C(=O)c3ccc([N+](=O)[O-])cc3F)CC2)c1.CC(C)O.Cl.[Fe]>>CC(C)(C)NC(=O)c1cccc(CN2CCN(C(=O)c3ccc(N)cc3F)CC2)c1",
        "output": "28"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)n1c(Cn2ccc(-c3ccnc(NC4CCOCC4)n3)cc2=O)cc2ccccc21.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1Cc1cc2ccccc2[nH]1",
        "output": "848"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.CSc1ccc(CC(=O)O)cc1Cl.O=S(=O)(O)O>>COC(=O)Cc1ccc(SC)c(Cl)c1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Nc1cc([N+](=O)[O-])ccc1C(=O)O.CCOC(C)=O.[H][H].[Pd]>>CC(=O)Nc1cc(N)ccc1C(=O)O",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.COc1nc(C)cc(CO)c1C#N.CS(=O)(=O)Cl.ClCCl>>COc1nc(C)cc(COS(C)(=O)=O)c1C#N",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.C[O-].O=C(O)c1ccc(CBr)c([N+](=O)[O-])c1.[Na+]>>COCc1ccc(C(=O)O)cc1[N+](=O)[O-]",
        "output": "464"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1oc2cccc(CC)c2c1C.CO.Cl.[Na+].[OH-]>>CCc1cccc2oc(C(=O)O)c(C)c12",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.COC(=O)c1cnc(N)c(C#C[Si](C)(C)C)c1.ClCCl.c1ccncc1>>COC(=O)c1cnc(NC(C)=O)c(C#C[Si](C)(C)C)c1",
        "output": "332"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COc1ccccc1-c1ccnc(Cl)n1.Nc1ccc(CS(N)(=O)=O)cc1>>COc1ccccc1-c1ccnc(Nc2ccc(CS(N)(=O)=O)cc2)n1",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1CCC(OC2c3ccccc3CCn3cc(-c4ccc(NC(=O)OC(C)(C)C)cc4)nc32)CC1.ClCCl.O.O=C(O)C(F)(F)F.[Na+].[OH-]>>CN1CCC(OC2c3ccccc3CCn3cc(-c4ccc(N)cc4)nc32)CC1",
        "output": "782"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cc1cc(C)c([N+](=O)[O-])c(C)n1.[Pd]>>Cc1cc(C)c(N)c(C)n1",
        "output": "269"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1cc(-c2cc(F)cc(Cl)c2)n(-c2cccc(Cl)c2)n1.O=C(O)c1cc(-c2cc(F)cc(Cl)c2)n(-c2ccc(F)c(Cl)c2)n1>>O=C(O)c1cc(-c2cc(F)cc(Cl)c2)n(-c2cccc(Cl)c2)n1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCn1c2ccc(F)cc2c2c(CC(=O)O)nn(-c3ccccc3)c(=O)c21.CNC.O=C(n1ccnc1)n1ccnc1>>CCn1c2ccc(F)cc2c2c(CC(=O)N(C)C)nn(-c3ccccc3)c(=O)c21",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(CN)CC1.CS(C)=O.Clc1nc(-n2cnc3ccccc32)c2nc[nH]c2n1>>CC(C)(C)OC(=O)N1CCC(CNc2nc(-n3cnc4ccccc43)c3nc[nH]c3n2)CC1",
        "output": "578"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCCCCn1cnc2ccccc21.CC#N.c1cc2c(cc1N1CCNCC1)OCCO2>>c1ccc2c(c1)ncn2CCCCN1CCN(c2ccc3c(c2)OCCO3)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)CNc1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2/C=C/c2ccc(Br)cc2)cc1.OB(O)c1cc(C(F)(F)F)ccc1F>>COC(=O)CNc1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2/C=C/c2ccc(-c3cc(C(F)(F)F)ccc3F)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCS(=O)(=O)CCN[C@H](C)c1nc2ccccc2c(=O)n1-c1ccc(OCC(F)(F)F)cc1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)Cc1ccc(F)c(C(F)(F)F)c1>>CCS(=O)(=O)CCN(C(=O)Cc1ccc(F)c(C(F)(F)F)c1)[C@H](C)c1nc2ccccc2c(=O)n1-c1ccc(OCC(F)(F)F)cc1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCNCC.ClCCl.O=C(O)c1ccc(C(=O)c2ccccc2)cc1.O=S(Cl)Cl.[Na+].[OH-]>>CCN(CC)C(=O)c1ccc(C(=O)c2ccccc2)cc1",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.COc1ccccc1N1CCN(C[C@H](N)Cc2ccccn2)CC1.ClCCl.O=C(Cl)C1CCCCC1>>COc1ccccc1N1CCN(C[C@@H](Cc2ccccn2)NC(=O)C2CCCCC2)CC1",
        "output": "45"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN.O.O=[N+]([O-])c1ccc(F)c(F)c1>>CNc1ccc([N+](=O)[O-])cc1F",
        "output": "572"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)C=C1CCCCC1.COCCO[AlH2-]OCCOC.Cc1ccccc1.[Na+]>>OCC=C1CCCCC1",
        "output": "150"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.NC(=O)Cn1ccc2c(N)cccc2c1=O.O=C(O)CC1CCCCCC1>>NC(=O)Cn1ccc2c(NC(=O)CC3CCCCCC3)cccc2c1=O",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC1Cc2ccc(C(=O)O)cc2C1.CCN(CC)CC.CN(C)c1ccccn1.ClCCl.Nc1ccccc1>>CC(C)(C)OC(=O)NC1Cc2ccc(C(=O)Nc3ccccc3)cc2C1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)c1ccc(N)cc1.O=Cc1ccc(-c2ccccc2)cc1>>CC(C)c1ccc(NCc2ccc(-c3ccccc3)cc2)cc1",
        "output": "359"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=C(O)CCc1ccccc1.OCCCc1ccccc1.[K+].[OH-]>>O=C(CCc1ccccc1)OCCCc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nn1nc(N2CCOCC2)c2ccccc2c1=O.O=C(O)Cc1ccc(OC(F)(F)F)cc1>>O=C(Cc1ccc(OC(F)(F)F)cc1)Nn1nc(N2CCOCC2)c2ccccc2c1=O",
        "output": "459"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.O=C1OC(CCO)c2ccccc21.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCC1OC(=O)c2ccccc21",
        "output": "193"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.Nc1cccc2ccc(O)cc12>>CC(C)(C)OC(=O)Nc1cccc2ccc(O)cc12",
        "output": "735"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CCCCO.CCN(CC)c1ccc(B2OC(C)(C)C(C)(C)O2)cn1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(Nc1ccccn1)N1c2nc(Cl)ccc2N2CC[C@H]1C2.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>CCN(CC)c1ccc(-c2ccc3c(n2)N(C(=O)Nc2ccccn2)[C@H]2CCN3C2)cn1",
        "output": "968"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.CCCCCC.CCOC(C)=O.COc1ccc(C2(C)C(=O)Nc3cc(N4CCN(C)CC4)cc(Cl)c3C2=O)cc1>>CN1CCN(c2cc(Cl)c3c(c2)NC(=O)C(C)(c2ccc(O)cc2)C3=O)CC1",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Cc1cc([N+](=O)[O-])ccc1Oc1cccc(OC(F)(F)C(F)F)c1.O.[Ca+2].[Cl-].[Cl-]>>Cc1cc(N)ccc1Oc1cccc(OC(F)(F)C(F)F)c1",
        "output": "335"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCC(O)c1ccnc(Br)c1.ClCCl.O=C([O-])[O-].[Na+].[Na+]>>CCC(=O)c1ccnc(Br)c1",
        "output": "32"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCOC(=O)CCc1ccc(O)c(OCCCOC)c1.ClCCl.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F.[Cl-].[NH4+]>>CCOC(=O)CCc1ccc(OS(=O)(=O)C(F)(F)F)c(OCCCOC)c1",
        "output": "843"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(=O)(=O)c1nccc(-n2cnc3ccccc32)n1.NCC1CC1>>c1ccc2c(c1)ncn2-c1ccnc(NCC2CC2)n1",
        "output": "629"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)c1ccccc1-c1ccc(Cl)c(C(=O)NCCC23CC4CC(CC(C4)C2)C3)c1.O.[K+].[OH-]>>O=C(NCCC12CC3CC(CC(C3)C1)C2)c1cc(-c2ccccc2C(=O)O)ccc1Cl",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNCC1.CC(C)O.CCn1cc(C(=O)O)c(=O)c2cc(Cl)c(Cl)cc21.CN(C)C=O.COCCO>>CCn1cc(C(=O)O)c(=O)c2cc(Cl)c(N3CCCCC3)cc21",
        "output": "280"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(CN2CCN(C(=O)OC(C)(C)C)CC2)cc1-c1ccc2c(n1)N(C)S(=O)(=O)N2CC1CC1(F)F.Cc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(CN2CCNCC2)cc1-c1ccc2c(n1)N(C)S(=O)(=O)N2CC1CC1(F)F",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Cc1nn(Cc2ccccc2)c2ccc([N+](=O)[O-])cc12.[H][H].[Pt]>>Cc1nn(Cc2ccccc2)c2ccc(N)cc12",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.O=[N+]([O-])c1ccc(F)c(F)c1.c1ccc(C(c2ccccc2)C2CCNCC2)cc1>>O=[N+]([O-])c1ccc(N2CCC(C(c3ccccc3)c3ccccc3)CC2)c(F)c1",
        "output": "26"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCC(O)CCCl.CN(C)C=O.c1c[nH]cn1>>CCC(CCCl)O[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.N#Cc1ccc(Sc2cccc(C(=O)O)c2)nc1.O.O=S(Cl)Cl.[BH4-].[Na+]>>N#Cc1ccc(Sc2cccc(CO)c2)nc1",
        "output": "72"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCOC(=O)c1cc2ccccc2cc1Oc1ccnc2cc(OCCCCl)c(OC)cc12.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+].c1c[nH]cn1>>CCCOC(=O)c1cc2ccccc2cc1Oc1ccnc2cc(OCCCn3ccnc3)c(OC)cc12",
        "output": "611"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C[C@@H](NC(=O)OC(C)(C)C)C(=O)O.NCCO.O=C(n1ccnc1)n1ccnc1>>C[C@@H](NC(=O)OC(C)(C)C)C(=O)NCCO",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=C(O)CC1(CCBr)CCCCC1.O=S(Cl)Cl>>COC(=O)CC1(CCBr)CCCCC1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOCC.CC[SiH](CC)CC.COCCCOc1cc(C(=O)[C@@H](C/C=C/C[C@H](C(=O)O)C(C)C)C(C)C)ccc1OC.ClCCCl.FB(F)F.O>>COCCCOc1cc(C[C@@H](C/C=C/C[C@H](C(=O)O)C(C)C)C(C)C)ccc1OC",
        "output": "92"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.NN.O.O=[N+]([O-])c1ccc(Br)cc1NCC1CCOCC1.[Ni]>>Nc1ccc(Br)cc1NCC1CCOCC1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.NCCc1ccc(F)c(OCC(F)(F)F)c1.O=C([O-])O.O=CC1CCOC1.[Na+].[Na+]>>Fc1ccc(CCNCC2CCOC2)cc1OCC(F)(F)F",
        "output": "426"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.COCOc1cc(OC)ccc1C(=O)c1ccc(O)cc1.Cc1oc(-c2ccccc2)nc1CCl.O.O=C([O-])[O-].[K+].[K+]>>COCOc1cc(OC)ccc1C(=O)c1ccc(OCc2nc(-c3ccccc3)oc2C)cc1",
        "output": "760"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.COc1cn(-c2ccc(-n3cc(F)c(F)c3)cc2OCc2ccccc2)nc(-c2ccnn2-c2ccccc2)c1=O.[Pd]>>COc1cn(-c2ccc(-n3cc(F)c(F)c3)cc2O)nc(-c2ccnn2-c2ccccc2)c1=O",
        "output": "23"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CO.N.N#Cc1cc(S(=O)(=O)Cl)ccc1F>>N#Cc1cc(S(N)(=O)=O)ccc1F",
        "output": "245"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.CN(C)c1nc2ccc(NC(=O)c3c(C(=O)O)cnn3C)cn2n1>>CN(C)c1nc2ccc(NC(=O)c3c(C(=O)N4CCCC4)cnn3C)cn2n1",
        "output": "733"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NCC(=O)OC(C)(C)C)nc12.ClCCl.O=C(O)C(F)(F)F>>Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NCC(=O)O)nc12",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CN1CCNCC1.O=C(OCc1ccccc1)c1cc(OCc2ccccc2)c2cccc(Br)c2n1>>O=C(OCc1ccccc1)c1cc(OCc2ccccc2)c2cccc(N3CCCCC3)c2n1",
        "output": "597"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1cccc(O)c1.CC(C)=O.CCN(CC)CC.CCOCC.ClCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1cccc(OCc2ccccc2)c1",
        "output": "49"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCBr.O=c1[nH]c2ccc3ccccc3c2[nH]1.[H-].[Na+]>>CCn1c(=O)[nH]c2c3ccccc3ccc21",
        "output": "276"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.O=C(Cl)C(=O)Cl.O=C(O)CCc1ccc(F)cc1F>>O=C(Cl)CCc1ccc(F)cc1F",
        "output": "56"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(C)=O.Cl[Sn]Cl.Cn1cccc1-c1nsc2ccc([N+](=O)[O-])cc12.O.O>>Cn1cccc1-c1nsc2ccc(N)cc12",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cc(F)c(Nc3nc(Cc4c(Cl)cccc4Cl)cc4cn[nH]c(=O)c34)cc2F)CC1.ClCCl.O=C(O)C(F)(F)F>>O=c1[nH]ncc2cc(Cc3c(Cl)cccc3Cl)nc(Nc3cc(F)c(N4CCNCC4)cc3F)c12",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)C1CC1c1cc(F)c(OCc2ccccc2)c(F)c1.[Pd]>>CCOC(=O)C1CC1c1cc(F)c(O)c(F)c1",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc2cccc(N3CCNCC3)c2c1.N#CCCCBr>>COc1ccc2cccc(N3CCN(CCCC#N)CC3)c2c1",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(Cn2nc(Nc3cc(Cl)nn(C)c3=O)nc2N)cc1.O=C(O)C(F)(F)F>>Cn1nc(Cl)cc(Nc2n[nH]c(N)n2)c1=O",
        "output": "978"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(CNC(=O)OCc1ccccc1)NC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21.CCO.[Pd]>>CC(C)(CN)NC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21",
        "output": "574"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CC[C@H](NC(=O)OC(C)(C)C)C(=O)N1c2ccc(Cl)cc2C[C@H]1C(=O)O.Cl.ClCCl.NCC(F)(F)F.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>>CC[C@H](NC(=O)OC(C)(C)C)C(=O)N1c2ccc(Cl)cc2C[C@H]1C(=O)NCC(F)(F)F",
        "output": "216"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=C(C)C(=O)Oc1ccc(C=O)cc1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.O.OCCO>>C=C(C)C(=O)Oc1ccc(C2OCCO2)cc1",
        "output": "117"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Cc1ncc(-c2cc(Oc3ccc([N+](=O)[O-])nc3)ccn2)n1C.[Pd]>>Cc1ncc(-c2cc(Oc3ccc(N)nc3)ccn2)n1C",
        "output": "457"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1oc(-c2ccccc2)nc1CC(=O)O.NC[C@H]1CN(Cc2ccc(Cl)c(Cl)c2)CCO1>>Cc1oc(-c2ccccc2)nc1CC(=O)NC[C@H]1CN(Cc2ccc(Cl)c(Cl)c2)CCO1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.O=C(OCc1ccccc1)N1CCC(CCC(F)(F)c2ccccc2)CC1.[OH-].[OH-].[Pd+2]>>FC(F)(CCC1CCNCC1)c1ccccc1",
        "output": "428"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCOCC.FB(F)F.O=Cc1cc([N+](=O)[O-])ccc1F.OCCO>>O=[N+]([O-])c1ccc(F)c(C2OCCO2)c1",
        "output": "117"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cl.O=C([O-])O.OC1CCNCC1.[Na+]>>CC(C)(C)OC(=O)N1CCC(O)CC1",
        "output": "694"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1.Cl.Cl.O=S(=O)(CCCCl)c1ccccc1>>COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCS(=O)(=O)c2ccccc2)CC1",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1nc(N)c2nc(C)n(CCN)c2c1C.O=C(Cl)N1CCOCC1>>Cc1nc(N)c2nc(C)n(CCNC(=O)N3CCOCC3)c2c1C",
        "output": "454"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)/N=N/C(=O)OCC.Cc1cc(O)cc(C)c1Br.OCCN1CCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(OCCN2CCCC2)cc(C)c1Br",
        "output": "478"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(COC(=O)Nc2nc3c(ncn3CC(=O)O)c(=O)[nH]2)cc1OC.O=C(O)C(F)(F)F.O=C1CNCCN1S(=O)(=O)c1nc2ccccc2s1>>COc1ccc(COC(=O)Nc2nc3c(ncn3CC(=O)N3CCN(S(=O)(=O)c4nc5ccccc5s4)C(=O)C3)c(=O)[nH]2)cc1OC",
        "output": "297"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NC1CNc2ccccc2NC1=O.Cc1ccc2c(c1)NC(=O)C(NC(=O)OC(C)(C)C)CN2.O=C(Cl)c1ccccc1>>Cc1ccc2c(c1)NC(=O)C(NC(=O)OC(C)(C)C)CN2C(=O)c1ccccc1",
        "output": "614"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.C1CNCCN1.O=Cc1cnc(Cl)s1.[Li+].[OH-]>>O=Cc1cnc(N2CCNCC2)s1",
        "output": "558"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCN1CC=C(c2cccc(C(F)(F)F)c2F)CC1.CO.Cl.[Pd]>>CCCN1CCC(c2cccc(C(F)(F)F)c2F)CC1",
        "output": "806"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)O.ClCCl.NCc1cccc(C(=O)N(Cc2ccc(F)cc2)Cc2cc(Cl)cc(Cl)c2)c1.O=C([O-])O.O=Cc1ccc(F)cc1.[Na+].[Na+]>>O=C(c1cccc(CNCc2ccc(F)cc2)c1)N(Cc1ccc(F)cc1)Cc1cc(Cl)cc(Cl)c1",
        "output": "683"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCN(C(=O)OCc2ccccc2)C1.CI.CN(C)C=O.O.[H-].[Na+]>>CN(C(=O)OC(C)(C)C)[C@H]1CCN(C(=O)OCc2ccccc2)C1",
        "output": "803"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.NC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.O=C(Cl)c1ccccc1.[Na+].[OH-]>>O=C(N[C@@H](CNC(=O)c1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21",
        "output": "271"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)N1C(=O)C(NCCN)=C(c2ccccc2)S1(=O)=O.CN(C)C=O.FC(F)(F)c1cnc(Cl)c(Cl)c1>>CC(C)(C)N1C(=O)C(NCCNc2ncc(C(F)(F)F)cc2Cl)=C(c2ccccc2)S1(=O)=O",
        "output": "70"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)N[C@@H](CC(=O)O)C(=O)OC(C)(C)C.CN(C)c1ccncc1.Cc1ccc(CN2CC[C@@H](N3CC[C@@H](c4ccc(O)cc4)[C@H](F)C3)C2=O)cc1.ClCCl.O>>Cc1ccc(CN2CC[C@@H](N3CC[C@@H](c4ccc(OC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc4)[C@H](F)C3)C2=O)cc1",
        "output": "108"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1nccn1-c1cccc(C(=O)CC(=O)Nc2cc(-c3ccc(F)cc3)ccc2NC(=O)OC(C)(C)C)c1.ClCCl.O=C(O)C(F)(F)F>>Cc1nccn1-c1cccc(C2=Nc3ccc(-c4ccc(F)cc4)cc3NC(=O)C2)c1",
        "output": "930"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CN(C)C=O.O.O=C(O)c1cc(OCc2ccccc2)c(F)c(F)c1Nc1ccccc1F.O=C([O-])O.[K+]>>O=C(OCc1ccccc1)c1cc(OCc2ccccc2)c(F)c(F)c1Nc1ccccc1F",
        "output": "403"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN.N#Cc1cncc(Cl)c1Cl>>CNc1c(Cl)cncc1C#N",
        "output": "78"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ccccc21.CN(C)C=O.CN(C)CCCN.CN1C(=O)C(F)(F)CN(C2CCCC2)c2nc(Nc3ccc(C(=O)O)cc3C(F)(F)F)ncc21.F[P-](F)(F)(F)(F)F.On1nnc2ccccc21>>CN(C)CCCNC(=O)c1ccc(Nc2ncc3c(n2)N(C2CCCC2)CC(F)(F)C(=O)N3C)c(C(F)(F)F)c1",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN.Cl.O=C(O)c1cc(S(=O)(=O)Cl)cc(F)c1F.[Na+].[OH-]>>CCNS(=O)(=O)c1cc(F)c(F)c(C(=O)O)c1",
        "output": "43"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "B.C1CCOC1.CB1OC(c2ccccc2)(c2ccccc2)[C@H]2CCCN12.CCOC(C)=O.O.O=C(COCCCl)c1cc2ccsc2cc1F>>OC(COCCCl)c1cc2ccsc2cc1F",
        "output": "24"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N(c1cc(C)cc(C#N)c1)c1[nH]c(=O)[nH]c(=O)c1C(C)C.CN(C)C=O.COc1ccc(CNc2cc(CBr)cc(F)n2)cc1.O=C([O-])[O-].[Cl-].[K+].[K+].[Li+]>>COc1ccc(CNc2cc(Cn3c(N(C(C)=O)c4cc(C)cc(C#N)c4)c(C(C)C)c(=O)[nH]c3=O)cc(F)n2)cc1",
        "output": "389"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "NCCO[N+](=O)[O-].O=C1NC(C(=O)O)C(c2cccnc2)S1.O=[N+]([O-])O>>O=C1NC(C(=O)NCCO[N+](=O)[O-])C(c2cccnc2)S1",
        "output": "216"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Cl.CO.COC(=O)c1nc(-c2ccc(I)c(F)c2F)cc(NC(C)=O)c1Cl>>COC(=O)c1nc(-c2ccc(I)c(F)c2F)cc(N)c1Cl",
        "output": "66"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCBr.CN(C)C=O.Oc1ccc(-c2ncccn2)cc1.[H-].[Na+]>>CCCCCCCCOc1ccc(-c2ncccn2)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C1CCOC1.CCOC(=O)CSc1nc2scc(-c3ccc(F)cc3)c2c(=O)n1-c1ccc(F)cc1.CN(C)C=O.Cl.[Na+].[OH-]>>O=C(O)CSc1nc2scc(-c3ccc(F)cc3)c2c(=O)n1-c1ccc(F)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1ccc2sccc2c1.CN(C)C=O.O.[C-]#N.[C-]#N.[Zn+2]>>N#Cc1ccc2sccc2c1",
        "output": "65"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)O.CN1CCOCC1.COC(=O)[C@@H](N)[C@@H](C)O.CS(C)=O.Cl>>COC(=O)[C@@H](NC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1)[C@@H](C)O",
        "output": "129"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCO.O=Cc1ccc2c(c1)C=C(C(=O)O)C(C(F)(F)F)O2.[BH4-].[Na+]>>O=C(O)C1=Cc2cc(CO)ccc2OC1C(F)(F)F",
        "output": "356"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1c(-c2ccc(Cl)cc2)n[nH]c1N.Cc1ccccc1.O=C(O)CS>>CCc1c(-c2ccc(Cl)cc2)n[nH]c1NC(=O)CS",
        "output": "795"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCc1ccc(C(=O)O)c(C)c1O.CC(=O)OC(C)=O.Cl.O.[Na+].[OH-]>>C=CCc1ccc(C(=O)O)c(C)c1OC(C)=O",
        "output": "46"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CCN(c2nc(C(F)(F)F)ccc2CN)CC1.CCN(CC)CC.CS(C)=O.O.O=C(Nc1nccc2ccccc12)Oc1ccccc1>>CC1CCN(c2nc(C(F)(F)F)ccc2CNC(=O)Nc2nccc3ccccc23)CC1",
        "output": "488"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCc1ccccc1.O=C(Cl)c1ccccc1.S=C=S.[Al+3].[Cl-].[Cl-].[Cl-]>>CCCCc1ccc(C(=O)c2ccccc2)cc1",
        "output": "61"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)CCNc1cc(Cc2c(-c3ccc(Cl)cc3)nc3ccccn23)ncn1.CN1CCNCC1.Clc1ccc(-c2nc3ccccn3c2Cc2cc(Cl)ncn2)cc1>>CN1CCN(c2cc(Cc3c(-c4ccc(Cl)cc4)nc4ccccn34)ncn2)CC1",
        "output": "162"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)CN1CCN(c2ccc(C#N)cc2)CC1.[Cl-].[Li+].[NH4+].[OH-]>>N#Cc1ccc(N2CCN(CC(=O)O)CC2)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.Nc1ccc(O)cc1.O.O=S(=O)(Cl)c1cccc2ccccc12>>O=S(=O)(Nc1ccc(O)cc1)c1cccc2ccccc12",
        "output": "68"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)(C)OC(=O)N[C@@H]1CCNC1.COc1ncnc2sc(NC(=O)Oc3ccccc3)nc12>>COc1ncnc2sc(NC(=O)N3CC[C@@H](NC(=O)OC(C)(C)C)C3)nc12",
        "output": "525"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1ccc2c(c1)C(C)(C)CC(c1ccccc1NS(=O)(=O)c1ccccc1F)N2.O.O.[Li+].[Na+].[OH-].[OH-]>>CC1(C)CC(c2ccccc2NS(=O)(=O)c2ccccc2F)Nc2ccc(C(=O)O)cc21",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CO.COc1cc2c(cc1OC)N(CCn1cc([N+](=O)[O-])cn1)CC2.O=[Pt]=O>>COc1cc2c(cc1OC)N(CCn1cc(N)cn1)CC2",
        "output": "628"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O=C1Cc2ccc(NC(=O)C3CCCC3)cc2N1.O=Cc1cc(Cl)ccc1O>>O=C1Nc2cc(NC(=O)C3CCCC3)ccc2C1=Cc1cc(Cl)ccc1O",
        "output": "439"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)OCCCCCCCCCCCCCCCCCCc1ccc(I)cc1.CO.O.[Na+].[OH-]>>OCCCCCCCCCCCCCCCCCCc1ccc(I)cc1",
        "output": "225"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1cccc2[nH]ccc12.CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O.O=S(=O)([O-])O.[Na+].[OH-]>>Cc1ccc(S(=O)(=O)n2ccc3c(Br)cccc32)cc1",
        "output": "648"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)/C=C/c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12.O.[Li+].[OH-]>>O=C(O)/C=C/c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12",
        "output": "122"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1cc(CC(=O)O)on1.Cl.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3OCC4)CC2)CC1>>Cc1cc(CC(=O)N[C@@H]2CC[C@@H](CCN3CCN(c4nccc5c4OCC5)CC3)CC2)on1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "N#Cc1ccccc1OCCF.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCc1ccccc1OCCF",
        "output": "175"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOCC.CN(C)c1ccncc1.Nc1ccccc1Cl.O.O=C(O)CCCCCCCCCC=C(F)F.O=S(Cl)Cl>>O=C(CCCCCCCCCC=C(F)F)Nc1ccccc1Cl",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(Cn2nc(NC3CCN(C)CC3)c3c(Oc4ccc(NC(=O)c5ccnn(-c6ccccn6)c5=O)cc4F)ccnc32)cc1.O=C(O)C(F)(F)F>>CN1CCC(Nc2n[nH]c3nccc(Oc4ccc(NC(=O)c5ccnn(-c6ccccn6)c5=O)cc4F)c23)CC1",
        "output": "978"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1ccc(CN2CCN(C(=O)OC(C)(C)C)CC2)cc1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1ccc(CN2CCNCC2)cc1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc(CCN)cc1.Cc1cccc(-c2cc(Cl)nc(N)n2)c1C>>Cc1ccc(CCNc2cc(-c3cccc(C)c3C)nc(N)n2)cc1",
        "output": "166"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccccc1OC1CN(C(c2ccccc2)c2ccccc2)C1.C1CNCCN1.CC(C)(C)[O-].Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>c1ccc(C(c2ccccc2)N2CC(Oc3ccccc3N3CCNCC3)C2)cc1",
        "output": "294"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.ClCCl.NCC(=O)N1c2ccccc2N(Cc2ccccc2)C(=O)[C@H]2CCC[C@H]21.O=C([O-])O.O=S(=O)(Cl)c1ccccc1.[Na+]>>O=C1[C@H]2CCC[C@H]2N(C(=O)CNS(=O)(=O)c2ccccc2)c2ccccc2N1Cc1ccccc1",
        "output": "596"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)Cn1c(C)cnc(NN)c1=O.Cl>>Cc1cnc(NN)c(=O)n1CC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.CCN(CC)CC.COC(=O)Cc1ccc(CN)cc1OCc1cccc(-c2cccc(CNC(=O)OC(C)(C)C)c2)c1.ClCCl.O>>COC(=O)Cc1ccc(CNC(C)=O)cc1OCc1cccc(-c2cccc(CNC(=O)OC(C)(C)C)c2)c1",
        "output": "206"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CCCC(=O)O.CCNCC.Cl>>C#CCCC(=O)N(CC)CC",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCCc1nc(CC)[nH]c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCN(CC)CC.CCOC(C)=O.ClCCl.OB(O)c1ccccc1.[Cu+2].c1ccncc1>>CCCc1nc(CC)n(-c2ccccc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "962"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)[O-].CCc1cccc2c(C(=O)O)cnnc12.CO.[Na+]>>CCc1cccc2c(C(=O)OC)cnnc12",
        "output": "195"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cc1cccc(C2NC(=O)CC(c3cccc(Cl)c3)C23C(=O)Nc2cc(Cl)ccc23)c1C.[BH4-].[Na+]>>Cc1cccc(C2NCCC(c3cccc(Cl)c3)C23C(=O)Nc2cc(Cl)ccc23)c1C",
        "output": "533"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COC(=O)/C=C/c1ccc2c(c1)C(=O)CC1(CCCN(C(=O)OC(C)(C)C)CC1)O2.[Na+]>>COC(=O)/C=C/c1ccc2c(c1)C(=O)CC1(CCCN(C)CC1)O2",
        "output": "881"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)Nc1cc(C#Cc2cnc3ccc(-c4ccc(C(N)=O)cc4)nn23)ccn1.ClCCl.O.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>NC(=O)c1ccc(-c2ccc3ncc(C#Cc4ccnc(N)c4)n3n2)cc1",
        "output": "885"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCN(Cc2ccccc2NC(=O)c2ccc(Cl)nc2)CC1.Cc1ccc(NC(=O)c2ccoc2)cc1B1OC(C)(C)C(C)(C)O1>>Cc1ccc(NC(=O)c2ccoc2)cc1-c1ccc(C(=O)Nc2ccccc2CN2CCN(C)CC2)cn1",
        "output": "955"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc(=O)n(-c2ccccc2)c1.O.[Li+].[OH-]>>O=C(O)c1ccc(=O)n(-c2ccccc2)c1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCOc1cccc(B(O)O)c1.O=C1CN(c2ccc(-n3cc(-c4ccc(Cl)cc4Cl)nc3Cc3ccc(Br)cc3)cc2)S(=O)(=O)N1>>CCCOc1cccc(-c2ccc(Cc3nc(-c4ccc(Cl)cc4Cl)cn3-c3ccc(N4CC(=O)NS4(=O)=O)cc3)cc2)c1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.Cc1cc([N+](=O)[O-])cc2[nH]ncc12.Cl.II.[Na+].[OH-]>>Cc1cc([N+](=O)[O-])cc2[nH]nc(I)c12",
        "output": "923"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc2c(Cl)ncnc2cc1OCC1CCN(C)CC1.O=C1COc2ccc(O)cc2N1>>COc1cc2c(Oc3ccc4c(c3)NC(=O)CO4)ncnc2cc1OCC1CCN(C)CC1",
        "output": "668"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CNc1cccc(CCO)n1.CS(=O)(=O)Cl.ClCCl>>CNc1cccc(CCOS(C)(=O)=O)n1",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCc1oc2ccccc2c1-c1ncc(-c2ccc3cc(OCC#N)ccc3c2)o1.CN(C)C=O.O.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+].[Na+].[OH-]>>CCCCc1oc2ccccc2c1-c1ncc(-c2ccc3cc(OCc4nnn[nH]4)ccc3c2)o1",
        "output": "366"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COCCNc1nc2ccc(OC)cc2cc1C=O.[BH4-].[Na+]>>COCCNc1nc2ccc(OC)cc2cc1CO",
        "output": "476"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)Nc1ccc(Br)cc1[N+](=O)[O-].CC(C)N1CCNCC1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>CC(C)N1CCN(c2ccc(NC(=O)OC(C)(C)C)c([N+](=O)[O-])c2)CC1",
        "output": "294"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCSc1ccc(Cl)cc1NNC(=O)c1cc(C)c(Br)cc1[N+](=O)[O-].CSc1ccc(Cl)cc1NN.Cc1cc(Br)c(N)c(C(=O)O)c1>>CSc1ccc(Cl)cc1NNC(=O)c1cc(C)cc(Br)c1N",
        "output": "55"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CNC(=O)c1ccc(C(=O)OC)cc1N.Cl.[Na+].[OH-]>>CNC(=O)c1ccc(C(=O)O)cc1N",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1cc(I)c(N)c([N+](=O)[O-])c1.O=N[O-].O=S(=O)(O)O.[Na+]>>Cc1cc(I)cc([N+](=O)[O-])c1",
        "output": "324"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C#N)cc1.CN(C)C=O.[Cl-].[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1",
        "output": "390"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.CC(=O)O.COc1ccc(-n2ccnc2C)cc1>>Cc1nccn1-c1ccc(O)cc1",
        "output": "402"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1ccc2cc[nH]c2n1.CI.CN(C)C=O.[H-].[Na+]>>Cn1ccc2ccc(Br)nc21",
        "output": "570"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[O-].CCO.CCOC(=O)c1cn[nH]c1.Fc1cc(CBr)ccc1-c1nc2ccc(C3(c4ccccc4)CC3)nc2s1>>CCOC(=O)c1cnn(Cc2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)c(F)c2)c1",
        "output": "635"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.Cc1ccccc1.O=C(O)c1ccc(CO)cc1C(F)(F)F.O=S(=O)(O)O>>COC(=O)c1ccc(CO)cc1C(F)(F)F",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)NS(=O)(=O)c1ccc(-c2ccc([N+](=O)[O-])cc2)cc1.CN(C)C=O.Cl[Sn]Cl.O.O>>CC(C)NS(=O)(=O)c1ccc(-c2ccc(N)cc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CI.CN(C)C=O.COc1cc2oc(=O)c(CCO)c(C)c2cc1O.O=C([O-])[O-].[K+].[K+]>>COc1cc2oc(=O)c(CCO)c(C)c2cc1OC",
        "output": "62"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN[C@@H](CCc2cccnc2)C1.ClCCl.O=C([O-])O.[Na+].[Na+]>>Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)[C@@H](CCc2cccnc2)C1",
        "output": "217"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.Nc1ncccc1C(=O)O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Nc1ncccc1CO",
        "output": "293"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCc1ccc2c(c1)C(=O)CSC2C(=O)OCC.CO.O.[K+].[OH-]>>CCCCCCc1ccc2c(c1)C(=O)CSC2C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC1(c2cc(F)cc(Sc3ccc(C(C)=O)c(O)c3)c2)CCOCC1.Cl.NO>>COC1(c2cc(F)cc(Sc3ccc(/C(C)=N/O)c(O)c3)c2)CCOCC1",
        "output": "212"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.[Pd].c1ccc(COc2ccc(-c3nc(-c4ccc(Oc5cccnc5)cc4)no3)cc2)cc1>>Oc1ccc(-c2nc(-c3ccc(Oc4cccnc4)cc3)no2)cc1",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)C(=O)Cl.CN(C)c1ccncc1.C[C@@H](CO)[C@H]1CC[C@H]2[C@@H](O[Si](C)(C)C(C)(C)C)CCC[C@]12C.Cl.c1ccncc1>>C[C@@H](COC(=O)C(C)(C)C)[C@H]1CC[C@H]2[C@@H](O[Si](C)(C)C(C)(C)C)CCC[C@]12C",
        "output": "126"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1CCNCC1.O=C(O)c1ccc(-c2ccncc2)s1>>CCOC(=O)C1CCN(C(=O)c2ccc(-c3ccncc3)s2)CC1",
        "output": "857"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCc2occ(C(=O)O)c2C1=O.Cn1cc2cc(N)ccc2n1.F[P-](F)(F)(F)(F)F>>CN1CCc2occ(C(=O)Nc3ccc4nn(C)cc4c3)c2C1=O",
        "output": "799"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CSc1nc2ccc(C=O)cc2s1.Cc1ccc(N)c([N+](=O)[O-])c1.O=C(O)C(F)(F)F.[Na+]>>CSc1nc2ccc(CNc3ccc(C)cc3[N+](=O)[O-])cc2s1",
        "output": "359"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CO.COC(=O)[C@@H]1CSCCN1S(=O)(=O)c1ccc(C)cc1.[Li+].[OH-]>>Cc1ccc(S(=O)(=O)N2CCSC[C@H]2C(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CC(C)(C)OC(=O)COc1ccc(CNc2ccc3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)cc1C#N.O.O.O.O.O.O.O.[Ce+3].[Cl-].[Cl-].[Cl-].[I-].[K+]>>N#Cc1cc(CNc2ccc3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)ccc1OCC(=O)O",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCC(C)=CCCC(CCCCCCC(=O)OCC)(C(C)=O)c1ccccc1.CCCCCC(CCCC(CCCCCCC(=O)OCC)(C(C)=O)c1ccccc1)OCc1ccccc1>>CCCCCC(C)=CCCC(CCCCCCC(=O)O)(C(C)=O)c1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)N=NC(=O)OCC.CN(C)CCCO.O=C(Nc1nccs1)c1nc(-c2ccc(O)cc2)[nH]c1-c1ccc(F)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN(C)CCCOc1ccc(-c2nc(C(=O)Nc3nccs3)c(-c3ccc(F)cc3)[nH]2)cc1",
        "output": "550"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1=COCCC1.CCOC(C)=O.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.O=Cc1ccc(O)cc1.c1cc[nH+]cc1>>O=Cc1ccc(OC2CCCCO2)cc1",
        "output": "319"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O.O=[N+]([O-])O.O=c1c(=O)c2cccc3c2-c2c1cccc2c(=O)c3=O>>O=c1c(=O)c2cc([N+](=O)[O-])cc3c2-c2c1cccc2c(=O)c3=O",
        "output": "21"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.ClCCl.O=C(c1ccncc1)N1CCC(c2nc3c(s2)CCNCC3)CC1.O=C1CCC1.[Na+]>>O=C(c1ccncc1)N1CCC(c2nc3c(s2)CCN(C2CCC2)CC3)CC1",
        "output": "187"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Oc1ccc2c(c1)C(O)CC(c1cccc(Cl)c1)O2.Oc1ccc2c(c1)CCC(c1cccc(F)c1)O2>>Oc1ccc2c(c1)CCC(c1cccc(Cl)c1)O2",
        "output": "447"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(=O)Nc1ccc(C2CCNCC2)cc1.ClCCCCCn1ccc2ccccc21>>CCC(=O)Nc1ccc(C2CCN(CCCCCn3ccc4ccccc43)CC2)cc1",
        "output": "138"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrP(Br)Br.CCc1cc(Br)ccc1CO.ClC(Cl)Cl>>CCc1cc(Br)ccc1CBr",
        "output": "300"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Brc1ccc2[nH]ccc2c1.C=CS(=O)(=O)c1ccccc1.CC#N.CC(=O)[O-].CC(=O)[O-].CCN(C(C)C)C(C)C.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.ClCCl.[Pd+2]>>O=S(=O)(/C=C/c1ccc2[nH]ccc2c1)c1ccccc1",
        "output": "539"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Cl.O=C(O)Cc1cccnn1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCc1cccnn1",
        "output": "231"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ncc(C2(O)CCC(=O)CC2)cc1C.O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1>>COc1ncc(C2(O)CCC(N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1C",
        "output": "187"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)Cc1ccc(C2CCCN2)cc1.FP(F)(F)(F)F.O=C(O)c1cc(Br)c(O)cc1O.O=C([O-])O.[Na+]>>CN(C)Cc1ccc(C2CCCN2C(=O)c2cc(Br)c(O)cc2O)cc1",
        "output": "794"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.Cc1ccc(S(=O)(=O)OCCc2ccc(N(C)C)cc2)cc1.O=C([O-])[O-].O[C@@H]1CCNC1.[I-].[Na+].[Na+].[Na+]>>CN(C)c1ccc(CCN2CC[C@@H](O)C2)cc1",
        "output": "429"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCBr.CC(C)(C)[O-].CN(C)C=O.N#Cc1ccc(O)cc1.[K+].[Na+].[OH-]>>C=CCOc1ccc(C#N)cc1",
        "output": "77"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1nc(-c2cc(Cl)c(C3CC3)cn2)no1.CC1(CO)COC1>>CC1(COc2cc(-c3noc(C(C)(C)C)n3)ncc2C2CC2)COC1",
        "output": "651"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCN1.CCOC(=O)c1cc(C(C)(C)C)nn1CC(=O)O.CN(C)C=O.Cl.ClCCCl.O.On1nnc2ccccc21>>CCOC(=O)c1cc(C(C)(C)C)nn1CC(=O)N1CCOCC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2cnc3c(NC(=O)c4ccccc4)ncnc32)C[C@@H]1O.COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1.O=C([O-])O.[Na+].c1ccncc1>>COc1ccc(C(O[C@H]2C[C@H](n3cnc4c(NC(=O)c5ccccc5)ncnc43)O[C@@H]2CO[Si](C)(C)C(C)(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1",
        "output": "250"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=C(O)[C@@H]1CCCN1.[Cl-]>>CCOC(=O)[C@@H]1CCCN1",
        "output": "536"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C(=O)O)c1ccc(C(=O)CCCCl)cc1.CO.Cl.[BH4-].[Na+]>>CC(C)(C(=O)O)c1ccc(C(O)CCCCl)cc1",
        "output": "24"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1ncc2cc(Oc3ccccc3)ccc2c1O.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)c1nc(Br)c2cc(Oc3ccccc3)ccc2c1O",
        "output": "779"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C(C#N)=NOC(N(C)C)=[N+](C)C.CN(C)C=O.COc1ccc(C2=NN(C3CCN(C(=O)[C@@H](N)CN(C)C)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.F[B-](F)(F)F.O=C(O)C(F)(F)F.O=C(O)c1c[nH]c2c(-c3c(OCC4CC4)ccc4c3OCO4)ncnc12.On1nnc2cccnc21>>COc1ccc(C2=NN(C3CCN(C(=O)[C@H](CN(C)C)NC(=O)c4c[nH]c5c(-c6c(OCC7CC7)ccc7c6OCO7)ncnc45)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC",
        "output": "989"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CC(C)(C)C(O)c1c(C)noc1-c1ccc(-c2ccc(C3(C(=O)OCC)CC3)cc2)cc1.Ic1ccccc1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4C(O)C(C)(C)/C=C/c4ccccc4)cc3)cc2)CC1",
        "output": "725"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.COCc1cc(C(C)C)nc(N)n1.ClCCl>>CC(C)c1cc(CO)nc(N)n1",
        "output": "423"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCCC1=O.CS(=O)(=O)OCC1(C(F)(F)F)CC1.CS(=O)(=O)c1ccc(-c2cc3c(cn2)OC(C2CCNCC2)C3)cc1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CS(=O)(=O)c1ccc(-c2cc3c(cn2)OC(C2CCN(CC4(C(F)(F)F)CC4)CC2)C3)cc1",
        "output": "496"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.C[C@H](O)CN.O=S(=O)(Nc1cccc(-c2nc(C3CCOCC3)sc2-c2ccnc(Cl)n2)c1F)c1ccoc1>>C[C@H](O)CNc1nccc(-c2sc(C3CCOCC3)nc2-c2cccc(NS(=O)(=O)c3ccoc3)c2F)n1",
        "output": "544"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O=[N+]([O-])c1cccc(Cl)c1N1CCCCC1.[Pd]>>Nc1cccc(Cl)c1N1CCCCC1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)Cn1c(C)c(Cc2ccccc2)c2cc(F)ccc21.O=S(=O)(O)Cl>>CCOC(=O)Cn1c(C)c(Cc2ccc(S(=O)(=O)Cl)cc2)c2cc(F)ccc21",
        "output": "182"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)Cc1cccc(C(=O)c2ccc(OCc3ccc4ccccc4n3)cc2)c1.Cc1ccccc1.[Li+].[OH-]>>O=C(O)Cc1cccc(C(=O)c2ccc(OCc3ccc4ccccc4n3)cc2)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN1c2ncc(CCOc3ccc(C(=O)OC)cc3C)cc2C(=O)N(C)c2cccnc21.CO.Cl.[Na+].[OH-]>>CCN1c2ncc(CCOc3ccc(C(=O)O)cc3C)cc2C(=O)N(C)c2cccnc21",
        "output": "222"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CC[C@H](CC(=O)OC(C)(C)C)C(=O)O.CC(C)(C)[C@H](N)C(=O)OCc1ccccc1.CCN=C=NCCCN(C)C.CCOC(C)=O.CN1CCOCC1.ClCCl.O.On1nnc2ccccc21>>C=CC[C@H](CC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)OCc1ccccc1)C(C)(C)C",
        "output": "132"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.C1CNCCN1.CCN(C(C)C)C(C)C.Nc1nc(Nc2ccc(N3CCOCC3)cc2)nn1-c1cc(Cl)ncn1>>Nc1nc(Nc2ccc(N3CCOCC3)cc2)nn1-c1cc(N2CCNCC2)ncn1",
        "output": "162"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCBr.CN(C)C=O.N#Cc1nc2ccc(O)cc2s1.O.O=C([O-])[O-].[K+].[K+]>>C=CCOc1ccc2nc(C#N)sc2c1",
        "output": "77"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCBr.CN(C)C=O.COC(=O)CCCc1ccc(O)c(-c2cc(CCCC(=O)OC)ccc2O)c1.O=C([O-])[O-].[Cu].[K+].[K+]>>CCCCCCCCOc1ccc(CCCC(=O)OC)cc1-c1cc(CCCC(=O)OC)ccc1O",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COc1ccc2c(c1)C(=O)C1(CCN(Cc3ccccc3)CC1)C2.[BH4-].[Na+]>>COc1ccc2c(c1)C(O)C1(CCN(Cc3ccccc3)CC1)C2",
        "output": "24"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCc1ccccc1O.Cl.ClCCl.O=C1CCC(=O)N1Br>>CCc1cccc(Br)c1O",
        "output": "4"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(CBr)c(Cl)c1Cl.CS(C)=O.[C-]#N.[Na+]>>COc1ccc(CC#N)c(Cl)c1Cl",
        "output": "39"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)Cl.CN.Cc1c(NC(=O)N2CCCC(C(=O)O)C2)ccc2c1c1ccccc1n2C(C)C>>CNC(=O)C1CCCN(C(=O)Nc2ccc3c(c2C)c2ccccc2n3C(C)C)C1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.Cc1nc(O)ccc1[N+](=O)[O-].ClP(Cl)(Cl)(Cl)Cl.O.O=P(Cl)(Cl)Cl>>Cc1nc(Cl)ccc1[N+](=O)[O-]",
        "output": "41"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1C(Oc1cccc2c1ccn2CC(=O)OC(C)(C)C)C(C)C.[Na+].[OH-]>>Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1C(Oc1cccc2c1ccn2CC(=O)O)C(C)C",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.N.O=C(O)c1ccc2c(c1)C=C(n1ccnc1)CC2>>NC(=O)c1ccc2c(c1)C=C(n1ccnc1)CC2",
        "output": "358"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3OCCCN3C(=O)c4ccccc4C3=O)nc12.CO.NN.O>>CCOC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3OCCCN)nc12",
        "output": "242"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C)(C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.Cc1noc(-c2ccc(Br)cc2)c1NC(=O)OC(C)(C)C>>CCOC(=O)C(C)(C)c1ccc(-c2ccc(-c3onc(C)c3NC(=O)OC(C)(C)C)cc2)cc1",
        "output": "933"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CN1CCNCC1.COC(=O)c1ccc(N(CCBr)S(C)(=O)=O)c(OCC2CC2)c1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(N(CCN2CCN(C)CC2)S(C)(=O)=O)c(OCC2CC2)c1",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(C=O)cc1OCCO.c1cc(NC2CC3CCC2N3)c2ccncc2c1>>Cc1ccc(CN2C3CCC2C(Nc2cccc4cnccc24)C3)cc1OCCO",
        "output": "567"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCCCc1ccc(C#Cc2ccc(CN(C(=O)CCC3CCCC3)c3ccc(C(=O)OCC)cc3)cc2)cc1.O.[Li]O>>CCCCc1ccc(C#Cc2ccc(CN(C(=O)CCC3CCCC3)c3ccc(C(=O)O)cc3)cc2)cc1",
        "output": "5"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(=O)CC1.CCN(CC)CC.ClCCl.[BH4-].[Na+]>>CC(C)(C)OC(=O)N1CCC(O)CC1",
        "output": "91"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CNC.Cc1ccccc1N1CN(CCO)C(=O)C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2>>Cc1ccccc1N1CN(CCN(C)C)C(=O)C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2",
        "output": "371"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC.COC(=O)[C@@H](N)CC(=O)OC(C)(C)C.O=C(O)CNC(=O)OCc1ccccc1>>COC(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)CNC(=O)OCc1ccccc1",
        "output": "129"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc(C=O)ccc1O.CS(=O)(=O)OCCN1c2ccccc2Sc2ccccc21>>COc1cc(C=O)ccc1OCCN1c2ccccc2Sc2ccccc21",
        "output": "702"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.O=C([O-])[O-].O=CC1CCCCC1.[Na+].[Na+].[Na+].c1nc2c(c(N3CCN(C4CCC4)CC3)n1)CCNC2>>c1nc2c(c(N3CCN(C4CCC4)CC3)n1)CCN(CC1CCCCC1)C2",
        "output": "484"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)c1cc(Cl)c2cccnc2c1N1CCNCC1.CCN(CC)CC.ClCCl.O=C(Cl)c1ccccc1>>CC(=O)c1cc(Cl)c2cccnc2c1N1CCN(C(=O)c2ccccc2)CC1",
        "output": "201"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.O=[N+]([O-])c1ccccc1-n1c2ccc(Br)cc2c2cccc(F)c21.[Cl-].[Cl-].[Na+].[OH-].[Zn+2]>>Nc1ccccc1-n1c2ccc(Br)cc2c2cccc(F)c21",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCOC(C)=O.CN(C)C=O.O=C(O)c1ccc(CBr)cc1.Oc1c(F)c(F)c(F)c(F)c1F>>O=C(Oc1c(F)c(F)c(F)c(F)c1F)c1ccc(CBr)cc1",
        "output": "355"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.COC(=O)CCCBr.Clc1ccc(OC2CCNCC2)cc1Cl.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>COC(=O)CCCN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)Cc1cccc(OCCCN(Cc2cccc(I)c2)CC(c2ccccc2)c2ccccc2)c1.[Na+].[OH-]>>O=C(O)Cc1cccc(OCCCN(Cc2cccc(I)c2)CC(c2ccccc2)c2ccccc2)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CCI.O=C([O-])[O-].O=Cc1ccc(-c2ccc(F)cc2F)cc1O.[K+].[K+]>>CCOc1cc(-c2ccc(F)cc2F)ccc1C=O",
        "output": "198"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O=C1CC(c2cccc(F)c2F)Oc2ccc(O)cc21.Oc1ccc2c(c1)C(O)CC(c1ccccc1)O2>>Oc1ccc2c(c1)C(O)CC(c1cccc(F)c1F)O2",
        "output": "24"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cl.NC1CCC(C(=O)O)CC1.O.[Na+].[OH-]>>CC(C)(C)OC(=O)NC1CCC(C(=O)O)CC1",
        "output": "631"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.BrBr.CC(=O)O.CC(=O)c1ccnc(Cl)n1.CCOCC>>O=C(CBr)c1ccnc(Cl)n1",
        "output": "173"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.CC(C)O.CC1(C)C(=O)NC(=O)N1CCN.CCN(C(C)C)C(C)C.CSc1ncc(Cl)c(-c2nnc(Cc3ccccc3)s2)n1.O.O=S([O-])OO.[K+]>>CC1(C)C(=O)NC(=O)N1CCNc1ncc(Cl)c(-c2nnc(Cc3ccccc3)s2)n1",
        "output": "101"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(NC(=O)NC2CC2)cc1B1OC(C)(C)C(C)(C)O1.Cn1c(=O)c(Br)cc2cnn(-c3c(F)cccc3F)c21>>Cc1ccc(NC(=O)NC2CC2)cc1-c1cc2cnn(-c3c(F)cccc3F)c2n(C)c1=O",
        "output": "938"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=CCCOc1ccc(C)cc1C(=O)OC.CO.O.[Li+].[OH-]>>C=CCCOc1ccc(C)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Fc1nc(F)c(F)c(N2CCOCC2)c1F.OCCN1CCOCC1.[H-].[Na+]>>Fc1nc(OCCN2CCOCC2)c(F)c(N2CCOCC2)c1F",
        "output": "541"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccccc1.O=[N+]([O-])c1ccc(I)c(O)c1>>O=[N+]([O-])c1ccc(I)c(OCc2ccccc2)c1",
        "output": "127"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)/C=C/C(=O)c1nn(-c2cccc(C(F)(F)F)c2)ccc1=O.NNc1cccc2ccccc12>>O=c1ccn(-c2cccc(C(F)(F)F)c2)nc1-c1ccnn1-c1cccc2ccccc12",
        "output": "984"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCO.Cl.N[C@H](CC(=O)O)C(=O)O>>CCOC(=O)[C@H](N)CC(=O)O",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)c1cc(F)cc2c1cnn2C.O.[Na+].[OH-]>>Cn1ncc2c(C(=O)O)cc(F)cc21",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.COC(=O)Cl.C[Si](C)(C)CCOCn1ccc2nc(-c3cccnc3N[C@H]3CCNC3)cnc21>>COC(=O)N1CC[C@H](Nc2ncccc2-c2cnc3c(ccn3COCC[Si](C)(C)C)n2)C1",
        "output": "219"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)CC(CCCSC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)O.CC(C)N=C=NC(C)C.CN(C)C=O.NCCc1ccc(-c2ccccc2)cc1.On1nnc2ccccc21>>CC(C)(C)OC(=O)CC(CCCSC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)NCCc1ccc(-c2ccccc2)cc1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.CN1CCNCC1CF.COc1cc([N+](=O)[O-])ccc1F.ClCCl.O.O=C([O-])[O-].[K+].[K+]>>COc1cc([N+](=O)[O-])ccc1N1CCN(C)C(CF)C1",
        "output": "26"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)CCO.CCN=C=NCCCN(C)C.Cl.Cl.ClCCl.O=C(O)Cc1ccccn1.c1ccncc1>>CC(C)CCOC(=O)Cc1ccccn1",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC(Cc1ccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)cc1)C(=O)O.CCN(CC)CC.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CNC.ClCCl.F[P-](F)(F)(F)(F)F>>CN(C)C(=O)C(Cc1ccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)cc1)NC(=O)OC(C)(C)C",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)c1ccc(C(=O)O)cc1.CO.O=S(=O)(O)O>>COC(=O)c1ccc(N(C)C)cc1",
        "output": "33"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)CC(=O)C(F)(F)F.CCOC(=O)CC(O)C(F)(F)F.CCOCC.Cl.[BH4-].[Na+]>>OCCC(O)C(F)(F)F",
        "output": "225"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CO.NCCO.O=Cc1ccc(Cl)nc1.O=S(=O)([O-])[O-].[BH4-].[Mg+2].[Na+]>>OCCNCc1ccc(Cl)nc1",
        "output": "441"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)C1CCN(Cc2c(O[C@@H]3CC[C@@H](C(C)(C)C)CC3)cc(C)c3ccccc23)CC1.CO.Cl.O.[H-].[Li+].[OH-]>>Cc1cc(O[C@@H]2CC[C@@H](C(C)(C)C)CC2)c(CN2CCC(C(=O)O)CC2)c2ccccc12",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc2c(cc1OC)C(Cc1ccc3ccccc3c1)NCC2.NCc1ccccc1.O=C(Br)CBr>>COc1cc2c(cc1OC)C(Cc1ccc3ccccc3c1)N(CC(=O)NCc1ccccc1)CC2",
        "output": "946"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)Cl.ClCCl.Nc1ccc(F)c(F)c1.O.O=C([O-])O.[Na+]>>COC(=O)Nc1ccc(F)c(F)c1",
        "output": "102"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br.CC(=O)O.O.O=C1c2ccccc2C(=O)N1Cc1nc(-c2ccccc2)oc1-c1ccccc1.[Na+].[OH-]>>NCc1nc(-c2ccccc2)oc1-c1ccccc1",
        "output": "242"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(O)Cn1ccc(N)n1.CCN(C(C)C)C(C)C.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.COc1ccccc1OC1=CC(=O)N([C@@H](CC2CCCO2)C(=O)O)C1.ClCCl.F[P-](F)(F)(F)(F)F>>COc1ccccc1OC1=CC(=O)N([C@@H](CC2CCCO2)C(=O)Nc2ccn(CC(C)(C)O)n2)C1",
        "output": "795"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)CCNCc1cccc2c(O)cccc12.CN(C)C=O.N#Cc1ccc(Cl)nc1.O=C([O-])[O-].[K+].[K+]>>CC(C)CCNCc1cccc2c(Oc3ccc(C#N)cn3)cccc12",
        "output": "516"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)CCCn1c(Nc2ccc(Br)cc2C)nc2c(Cl)ccc(C(CC)CC)c21.[BH4-].[Li+]>>CCC(CC)c1ccc(Cl)c2nc(Nc3ccc(Br)cc3C)n(CCCCO)c12",
        "output": "225"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1cc(C(C)(C)C)ncc1O.CN(C)C=O.O=C([O-])O.O=C1CCC(=O)N1Br.[Na+]>>CCOC(=O)c1cc(C(C)(C)C)nc(Br)c1O",
        "output": "779"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(Cl)OC(=O)Cl.ClC(Cl)Cl.OCc1cccs1.c1ccncc1>>CC(Cl)OC(=O)OCc1cccs1",
        "output": "144"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)/C=C/c1cc(=O)n(CC2OCCO2)c2cc(OC)ccc12.O=C(O)C(F)(F)F>>CCOC(=O)/C=C/c1cc(=O)n(CC=O)c2cc(OC)ccc12",
        "output": "740"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(CBr)CC1.CN(C)C=O.Cc1ncc[nH]1.[H-].[Na+]>>Cc1nccn1CC1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "276"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1ccc(-c2cc(Cl)ncn2)cc1.CN(C)C=O.Cc1nc2cc(O)ccc2s1.[H-].[Na+]>>Cc1nc2cc(Oc3cc(-c4ccc(C(C)(C)C)cc4)ncn3)ccc2s1",
        "output": "668"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.ClCCl.O.O=C(NC1CCCCC1)c1n[nH]c2ccc([N+](=O)[O-])cc12.O=C[O-].[NH4+].[OH-].[OH-].[Pd+2]>>Nc1ccc2[nH]nc(C(=O)NC3CCCCC3)c2c1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CO.Cc1nc(N2CCC(C(=O)O)CC2)c(C#N)cc1C(=O)OC(C)C.ClCCl.NS(=O)(=O)Cc1ccc(F)cc1.O.O=S(=O)([O-])O.On1nnc2ccccc21.[K+]>>Cc1nc(N2CCC(C(=O)NS(=O)(=O)Cc3ccc(F)cc3)CC2)c(C#N)cc1C(=O)OC(C)C",
        "output": "644"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCc2c(C(F)(F)F)n[nH]c2C1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CN1CCc2c(C(F)(F)F)n[nH]c2C1",
        "output": "881"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CCO.CCOC(C)=O.Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCCC4)cc3c2CCN(CCCCc2ccc(NS(C)(=O)=O)cc2)C(=O)OCc2ccccc2)c1.[H][H].[NH4+].[OH-].[OH-].[OH-].[Pd+2]>>Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4CCCC4)cc3c2CCNCCCCc2ccc(NS(C)(=O)=O)cc2)c1",
        "output": "428"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cnc(-c2ccc(C(F)(F)F)cc2)n1C.Cl.[Na+].[OH-]>>Cn1c(C(=O)O)cnc1-c1ccc(C(F)(F)F)cc1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "N#Cc1cc(Br)c2c(c1)cc1n2CCCNC1=O.OB(O)c1ccc(F)cc1>>N#Cc1cc(-c2ccc(F)cc2)c2c(c1)cc1n2CCCNC1=O",
        "output": "833"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrC(Br)(Br)Br.Cc1c(CO)ccc(F)c1F.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1c(CBr)ccc(F)c1F",
        "output": "750"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1cnc(Cl)cc1C(=O)O.ClCCl.O=C(O)C(F)(F)F>>Nc1cnc(Cl)cc1C(=O)O",
        "output": "877"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(Cc1ccccc1)NC(=O)C(F)(F)F.ClC(Cl)Cl.O.O=S(=O)(O)Cl>>CC(C)(Cc1ccc(S(=O)(=O)Cl)cc1)NC(=O)C(F)(F)F",
        "output": "182"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-n1cnc2c(C(=O)O)cccc2c1=O.Cl.F[P-](F)(F)(F)(F)F>>CNC(=O)c1cccc2c(=O)n(-c3cc(NC(=O)c4cccc(C(C)(C)C#N)c4)ccc3C)cnc12",
        "output": "674"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.O=C([O-])[O-].O=C([O-])[O-].O=C1CCC(=O)N1Br.OCc1ccnc(Cl)c1.[K+].[K+].[Na+].[Na+]>>O=Cc1ccnc(Cl)c1",
        "output": "179"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(=O)NCSC[C@H](NC(=O)OC(C)(C)C)C(=O)O.CCOC(C)=O.O=[N+]([O-])c1ccc(O)cc1>>CC(=O)NCSC[C@H](NC(=O)OC(C)(C)C)C(=O)Oc1ccc([N+](=O)[O-])cc1",
        "output": "108"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOc1cccc2c1cc(C(=O)Nc1ccc(N3CCN(C(=O)CC4SC(=O)NC4=O)CC3)cc1)n2CC.CCn1c(C(=O)Nc2ccc(N3CCNCC3)cc2)cc2c(Cl)c(Cl)ccc21.Cl.O=C(O)CC1SC(=O)NC1=O>>CCn1c(C(=O)Nc2ccc(N3CCN(C(=O)CC4SC(=O)NC4=O)CC3)cc2)cc2c(Cl)c(Cl)ccc21",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCI.CN(C)C=O.Ic1c(-c2ccncc2)nn2c(C3CC4CCC(C3)N4)ccnc12.O=C([O-])[O-].[K+].[K+]>>CCN1C2CCC1CC(c1ccnc3c(I)c(-c4ccncc4)nn13)C2",
        "output": "184"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1C=C[C@H](C(=O)O)C1.CCOC(C)=O.CI.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>COC(=O)[C@H]1C=C[C@@H](NC(=O)OC(C)(C)C)C1",
        "output": "415"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.N#Cc1cccc(N)c1.[Pd]>>NCc1cccc(N)c1",
        "output": "175"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1NCCn2c(Br)cnc21.O=C(O)c1cc2ncc(Br)cn2n1>>CN1c2ncc(Br)n2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "995"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)OC(=O)Nc2ccc(-c3ccc(C#N)[nH]3)cc21.CCCCCI>>CCCCCn1c(C#N)ccc1-c1ccc2c(c1)C(C)(C)OC(=O)N2",
        "output": "302"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)SCCC(=O)N1N=C(c2ccccc2)CC1C(=O)O.[NH4+].[OH-]>>O=C(O)C1CC(c2ccccc2)=NN1C(=O)CCS",
        "output": "90"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "B.C1CCOC1.CNC(=O)CCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12.Cl>>CNCCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12",
        "output": "112"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)c1cc(C#N)c(Cl)nc1C.NC1CCC(C(=O)O)C1.[Cl-].[NH4+]>>CCOC(=O)c1cc(C#N)c(NC2CCC(C(=O)O)C2)nc1C",
        "output": "70"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N(C)C.CC(C)(C)[O-].CCOC(C)=O.NCc1ccccc1OCCN1CCOCC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=c1[nH]nc(Cl)c2cc(Br)ccc12.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>O=c1[nH]nc(Cl)c2cc(NCc3ccccc3OCCN3CCOCC3)ccc12",
        "output": "932"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1ccc2cc(-c3ccc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)cc3C)ccc2n1.CO.Cl.O.[Na+].[OH-]>>Cc1cc(OCc2c(-c3c(Cl)cccc3Cl)noc2C(C)C)ccc1-c1ccc2nc(C(=O)O)ccc2c1",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(=O)(=O)Cl.ClC(Cl)Cl.O[C@@H]1CC[C@@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)CC1>>CS(=O)(=O)O[C@@H]1CC[C@@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)CC1",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.NCCO.O=C(Nc1nc(-c2ccco2)c(N2CCOCC2)s1)c1ccc(Cl)nc1>>O=C(Nc1nc(-c2ccco2)c(N2CCOCC2)s1)c1ccc(NCCO)nc1",
        "output": "70"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCC(O)C=CC1CCC(=O)N1CC(=O)CCCCC(=O)O.CCO.[BH4-].[Na+]>>CCCCCC(O)C=CC1CCC(=O)N1CC(O)CCCCC(=O)O",
        "output": "91"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)Cc1cc2ccc(F)cc2c(C2CCN(C(=O)Nc3ccccc3OC)CC2)c1C.O.O.[Li+].[OH-]>>COc1ccccc1NC(=O)N1CCC(c2c(C)c(CC(=O)O)cc3ccc(F)cc23)CC1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cc(N)cc(OC)c1.CS(=O)(=O)Cl.c1ccncc1>>COc1cc(NS(C)(=O)=O)cc(OC)c1",
        "output": "194"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.COC(=O)Nc1ccnc(Cl)n1.CS(C)=O.C[C@H](N)c1cc2cc(Cl)ccc2[nH]c1=O.Cl.O>>COC(=O)Nc1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1",
        "output": "544"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1cccc2oc(-c3ccc(Cl)cc3)nc12.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>Clc1ccc(-c2nc3c(CBr)cccc3o2)cc1",
        "output": "625"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1C[C@@H]2CNC[C@@H]2C1.CC(C)(C)[O-].Cc1ccccc1.FC(F)(F)c1ccccc1Br.O.[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)OC(=O)N1C[C@@H]2CN(c3ccccc3C(F)(F)F)C[C@@H]2C1",
        "output": "294"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)c1ccc(-c2cccnc2)cn1.Cl>>O=C(O)c1ccc(-c2cccnc2)cn1",
        "output": "569"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C(=O)Cl)c1ccc(C2=CCCCC2)cc1.CCO.c1ccncc1>>CCOC(=O)C(C)c1ccc(C2=CCCCC2)cc1",
        "output": "126"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc([N+](=O)[O-])c2ncccc12.Cl.Cl[Sn]Cl>>Cc1ccc(N)c2ncccc12",
        "output": "269"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CO.Cc1ccc(Cl)c(C(=O)O)c1.ClCCl.O=C(Cl)C(=O)Cl>>COC(=O)c1cc(C)ccc1Cl",
        "output": "195"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1cccc(C2(c3ccccn3)c3ccccc3-c3ccccc32)c1.CS(C)=O.O=C(O)c1ccccn1.O=P([O-])([O-])[O-].Oc1cccc(C2(c3ccccn3)c3ccccc3-c3ccccc32)c1.[Cl-].[Cu]I.[K+].[K+].[K+].[Li+]>>c1ccc(C2(c3cccc(Oc4cccc(C5(c6ccccn6)c6ccccc6-c6ccccc65)c4)c3)c3ccccc3-c3ccccc32)nc1",
        "output": "238"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)c1cccc(Cc2ccc(Cl)cc2)c1.ClCCl.O.O=C1CCC(=O)N1Br>>CN(C)c1ccc(Br)c(Cc2ccc(Cl)cc2)c1",
        "output": "4"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)CCc1cccc(N)c1.CN(C)C=O.COc1cccc([C@H]2O[C@H](CC(=O)O)C(=O)N(CC(C)(C)COC(C)=O)c3ccc(Cl)cc32)c1OC.Cl.O.O=S(Cl)Cl>>CCOC(=O)CCc1cccc(NC(=O)C[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3N(CC(C)(C)COC(C)=O)C2=O)c1",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCn1c(=O)c2c(nc(N3CCCCC3)n2Cc2c(F)cccc2Cl)n(CC(=O)OC(C)(C)C)c1=O.ClCCl.O=C(O)C(F)(F)F>>CCn1c(=O)c2c(nc(N3CCCCC3)n2Cc2c(F)cccc2Cl)n(CC(=O)O)c1=O",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(=CCBr)C(C)CC=C(C)C.Oc1ccc2c(c1)OCCC2>>CCC(=CCOc1ccc2c(c1)OCCC2)C(C)CC=C(C)C",
        "output": "77"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCCC[C@@H](C)N.ClCCl.O=Cc1ccccc1.[Na+].[Na+].[OH-]>>CCCCC[C@@H](C)NCc1ccccc1",
        "output": "468"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)N(C)C.CNc1cccc(CCOc2ccc(C[C@H](NC(=O)C3CCCN3C(C)C)C(=O)OC)cc2)n1.[Na+].[OH-]>>CNc1cccc(CCOc2ccc(C[C@H](NC(=O)C3CCCN3C(C)C)C(=O)O)cc2)n1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CN1CCCC1CCN.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Oc2ccnc(Cl)n2)cc1.O=C([O-])[O-].[Na+].[Na+]>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Oc2ccnc(NCCC3CCCN3C)n2)cc1",
        "output": "544"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(Cn2cc(NC(C)=O)c(-c3nc(-c4ccccc4)c[nH]3)n2)cc1.COc1ccccc1.O=C(O)C(F)(F)F>>CC(=O)Nc1c[nH]nc1-c1nc(-c2ccccc2)c[nH]1",
        "output": "940"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1c(O)c2cc(Br)ccc2oc1=O.OB(O)c1ccc(C(F)(F)F)cc1>>COC(=O)c1c(O)c2cc(-c3ccc(C(F)(F)F)cc3)ccc2oc1=O",
        "output": "837"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Nc1ccccc1.O=C(Nc1cccc(C(F)(F)F)c1)c1ccc(Cl)c(-c2cccc([N+](=O)[O-])c2)c1.[OH-].[OH-].[Pd+2]>>Nc1cccc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc2Cl)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "N#Cc1cc(C(=O)c2ccc(F)cc2)n2c1ccc1ccccc12.c1cn[nH]c1>>N#Cc1cc(C(=O)c2ccc(-n3cccn3)cc2)n2c1ccc1ccccc12",
        "output": "751"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COC(=O)c1cc(CN=[N+]=[N-])cc(-c2cccc(C#N)c2)c1.O=C([O-])[O-].O=C([O-])[O-].[Ba+2].[H][H].[Pd+2]>>COC(=O)c1cc(CN)cc(-c2cccc(C#N)c2)c1",
        "output": "562"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(CC(CC=O)c1ccc(F)c(F)c1)C(=O)c1cccc2c1CCCC2.CS(=O)(=O)c1ccccc1C1CCNCC1.O>>CN(CC(CCN1CCC(c2ccccc2S(C)(=O)=O)CC1)c1ccc(F)c(F)c1)C(=O)c1cccc2c1CCCC2",
        "output": "484"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.ClCCCl.N[C@@H](CO)Cc1c[nH]c2ccccc12.O.O=C(O)c1cc(I)cc2c1OCC=C2.On1nnc2ccccc21>>O=C(N[C@@H](CO)Cc1c[nH]c2ccccc12)c1cc(I)cc2c1OCC=C2",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cnc(Nc2ccc(N3CCCCC3)cc2)[nH]c1=O.CO.[Na+].[OH-]>>O=C(O)c1cnc(Nc2ccc(N3CCCCC3)cc2)[nH]c1=O",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1ccc(S(=O)(=O)O)cc1.O=C(O)C1(c2ccccc2)CCNCC1.O=S(=O)(O)O.[Na+].[OH-]>>COC(=O)C1(c2ccccc2)CCNCC1",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)N(C)C.CN(C)C=O.Cn1nccc1C(=O)O.Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)ccc1F.O=S(Cl)Cl>>Cn1nccc1C(=O)Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)ccc1F",
        "output": "844"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C(=O)c1cc2c(s1)-c1cc(C(=O)O)ccc1OC2)c1ccc(F)cc1F.OC1CCNCC1>>CN(C(=O)c1cc2c(s1)-c1cc(C(=O)N3CCC(O)CC3)ccc1OC2)c1ccc(F)cc1F",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)CCNC(=O)c1c[nH]c2c(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)cccc12.Cl.[Na+].[OH-]>>CC(C)Oc1ccc(-c2nc(-c3cccc4c(C(=O)NCCC(=O)O)c[nH]c34)no2)cc1Cl",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1ccc(OCCCCC2Cc3c(OC)c(OC)c(OC)c(OC)c3C2=O)cc1.Cl.O.[BH4-].[Na+]>>COC(=O)c1ccc(OCCCCC2Cc3c(OC)c(OC)c(OC)c(OC)c3C2O)cc1",
        "output": "24"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCc1ccc(O)cc1.O=C([O-])O.[Na+].[Na+].[OH-]>>CC(C)(C)OC(=O)NCCc1ccc(O)cc1",
        "output": "631"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1=C(CO)C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)Cc3cccs3)[C@H]2S1.ClCCl.O=C(O)CC(O)(CC(=O)O)C(=O)O.c1ccncc1>>CC1=C(C=O)C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)Cc3cccs3)[C@H]2S1",
        "output": "183"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Cl.N#Cc1cc(C=O)ccc1F.NO.c1ccncc1>>N#Cc1cc(C=NO)ccc1F",
        "output": "30"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCc1cnn(C)c1NC(c1ccccc1)(c1ccccc1)c1ccccc1.CO.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>Cn1ncc(CCC(=O)O)c1NC(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.O.O=C(O)C(O)C1CCCN1.O=C([O-])O.[Na+].[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCCC1C(O)C(=O)O",
        "output": "694"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cl.ClCCl.F[P-](F)(F)(F)(F)F.NC(=O)n1cc(CC(=O)O)c2ccccc21.O=C(Nc1cccc(OC(F)(F)F)c1)[C@@H]1CCCN1.O=C(O)C(F)(F)F>>NC(=O)n1cc(CC(=O)N2CCC[C@H]2C(=O)Nc2cccc(OC(F)(F)F)c2)c2ccccc21",
        "output": "297"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCc1cnc(N2CCC(NC3CC3)CC2)nc1.O=C(O)c1ccc(-c2cnco2)nc1>>CCc1cnc(N2CCC(N(C(=O)c3ccc(-c4cnco4)nc3)C3CC3)CC2)nc1",
        "output": "256"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(Oc1cccc(Oc2ccccc2[N+](=O)[O-])c1)c1nnn[nH]1.CCO.[C].[Pd]>>CC(Oc1cccc(Oc2ccccc2N)c1)c1nnn[nH]1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCc1ccc(=O)[nH]c1.Ic1ccccc1>>CCc1ccc(=O)n(-c2ccccc2)c1",
        "output": "267"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.COc1cc(CO)nn1-c1ccc(C(F)(F)F)cc1.ClCCl>>COc1cc(C=O)nn1-c1ccc(C(F)(F)F)cc1",
        "output": "573"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CC[C@@H](C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)O)C1=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1ccc(CN2Cc3ccccc3C[C@@H]2[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)cc1.ClCCl.F[P-](F)(F)(F)(F)F>>CC[C@@H](C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2Cc3ccccc3CN2Cc2ccc(OC)cc2)C1=O",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.ClCCl.Nc1cc(Cl)ccn1.O.O=C(O)c1cccc(Cl)c1>>O=C(Nc1cc(Cl)ccn1)c1cccc(Cl)c1",
        "output": "744"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1cc(-c2nc(C3CCNCC3)cs2)cc(C(C)(C)C)c1O.Cc1nc(C)n(CC(=O)O)n1>>Cc1nc(C)n(CC(=O)N2CCC(c3csc(-c4cc(C(C)(C)C)c(O)c(C(C)(C)C)c4)n3)CC2)n1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)[Al+]C(C)C.CCOC(=O)C=Cc1cc2nc(-c3ccco3)nn2c(NCc2ccc(OC)c(OC)c2)n1.CCOC(C)=O.Cc1ccccc1.ClCCl.O=C([O-])[C@H](O)[C@@H](O)C(=O)[O-].[H-].[K+].[Na+]>>COc1ccc(CNc2nc(/C=C/CO)cc3nc(-c4ccco4)nn23)cc1OC",
        "output": "150"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.O=C(Nc1ccc(C#CC2CCCCC2)cc1C(=O)O)c1ccc(C2CCCCC2)cc1.[Pd]>>O=C(Nc1ccc(CCC2CCCCC2)cc1C(=O)O)c1ccc(C2CCCCC2)cc1",
        "output": "717"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NC1CCN(CCN2C(=O)COc3ccc(Br)nc32)CC1.N#Cc1ccc2ccc(=O)n(CCN3CCC(N)CC3)c2c1>>NC1CCN(CCN2C(=O)COc3ccc(Br)nc32)CC1",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Nc1ccc(C(F)(F)F)cc1Cl.O=C(O)c1cc(Br)ccc1O>>O=C(Nc1ccc(C(F)(F)F)cc1Cl)c1cc(Br)ccc1O",
        "output": "50"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(O)[C@H]1CCCNC1.CCN(CC)CC.Cl.ClCCl.O=C(O)c1conc1-c1ccccc1Cl.O=S(Cl)Cl>>CC(C)(O)[C@H]1CCCN(C(=O)c2conc2-c2ccccc2Cl)C1",
        "output": "975"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1c2n(c3c(Br)cc(Cl)cc13)CCNC2=O.OB(O)c1ccc(F)cc1>>Cc1c2n(c3c(-c4ccc(F)cc4)cc(Cl)cc13)CCNC2=O",
        "output": "833"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCO.CNCCN(C)C.Cc1nc(Cl)ccc1C(=O)Nc1ccc(Cl)c(-c2ccccn2)c1>>Cc1nc(N(C)CCN(C)C)ccc1C(=O)Nc1ccc(Cl)c(-c2ccccn2)c1",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1ccn2c(Cc3ccc4nc(N[C@@H]5CCCC[C@H]5O)sc4c3)cnc2c1.CO.Cl.[BH4-].[Na+]>>CC(O)c1ccn2c(Cc3ccc4nc(N[C@@H]5CCCC[C@H]5O)sc4c3)cnc2c1",
        "output": "24"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNC1.CCOC(C)=O.COCCOC.COc1cc2c(cc1OCC1CO1)CCC2=O>>COc1cc2c(cc1OCC(O)CN1CCCC1)CCC2=O",
        "output": "76"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)C=C(C)C(F)(F)F.O=S(=O)(O)O.[H-]>>CC(=CCO)C(F)(F)F",
        "output": "150"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "B.C1CCOC1.C1CCOC1.CC(C)(C)OC(=O)N1CCCC[C@@H]1C(=O)O.O>>CC(C)(C)OC(=O)N1CCCC[C@@H]1CO",
        "output": "218"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C(=O)O)c1cccc(B(O)O)c1.COCCOC.COc1nc(Cl)cc(NCC2Cc3ccccc3O2)n1.O.O=C([O-])[O-].[Cs+].[Cs+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1nc(NCC2Cc3ccccc3O2)cc(-c2cccc(C(C)(C)C(=O)O)c2)n1",
        "output": "884"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1c2c(nn1-c1nnc(-c3ccc(OC(C)C)c(C#N)c3)s1)CCN(CC(=O)OC(C)(C)C)C2.ClCCl.O=C(O)C(F)(F)F>>Cc1c2c(nn1-c1nnc(-c3ccc(OC(C)C)c(C#N)c3)s1)CCN(CC(=O)O)C2",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc2c(-c3cccs3)n[nH]c(=O)c2c1.O=P(Cl)(Cl)Cl>>COc1ccc2c(-c3cccs3)nnc(Cl)c2c1",
        "output": "537"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC1=CC2C(C1)CC2(CC(=O)OC(C)(C)C)C[N+](=O)[O-].CCO.[H][H].[Ni]>>CCC1=CC2C(C1)CC2(CN)CC(=O)OC(C)(C)C",
        "output": "226"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CO.COc1ccc2ncnc(CCC3(O)CCC(N)CC3)c2c1.O=Cc1ccc2nsnc2c1.[Na+]>>COc1ccc2ncnc(CCC3(O)CCC(NCc4ccc5nsnc5c4)CC3)c2c1",
        "output": "468"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CO.COC(=O)c1ccc([C@H]2CC(=O)c3ccccc3O2)cc1.CON.Cl.[Na+]>>CON=C1C[C@H](c2ccc(C(=O)OC)cc2)Oc2ccccc21",
        "output": "212"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CNCCC#Cc1ccccn1.O=S(=O)(Cl)c1ccc(F)cc1>>CN(CCC#Cc1ccccn1)S(=O)(=O)c1ccc(F)cc1",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CCCc1nc2cnc3ccccc3c2n1CCCCC(=O)OCC.[NH4+].[NH4+].[OH-]>>CCCc1nc2cnc3ccccc3c2n1CCCCC(N)=O",
        "output": "163"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CO.c1ccc(COc2ccccc2OCc2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)cc1>>c1ccc(COc2ccccc2OCc2c[nH]cn2)cc1",
        "output": "838"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1c(C)nc2cccc(OCC(C)(C)C(=O)O)c2c1N.NC1CCCCCCC1>>CCOC(=O)c1c(C)nc2cccc(OCC(C)(C)C(=O)NC3CCCCCCC3)c2c1N",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)CCc1ccccc1.CN(C)C=O.COC(OC)N(C)C>>CN(C)C=CC(=O)CCc1ccccc1",
        "output": "576"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNC1.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.Nc1ccc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c(CC(=O)O)c1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>Nc1ccc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c(CC(=O)N2CCC2)c1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)c1cn(C(C)c2ccccc2)nc1C.Cl.O.O.[Li+].[OH-]>>Cc1nn(C(C)c2ccccc2)cc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCc1nc2c(Cl)ccc(OCC(=O)OC)c2c(OC(F)F)c1Cc1ccc(C#N)cc1Cl.CO.O.[Li+].[OH-]>>CCc1nc2c(Cl)ccc(OCC(=O)O)c2c(OC(F)F)c1Cc1ccc(C#N)cc1Cl",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1[nH]c2ccc(Cl)cc2c1C1CCNCC1.O=CC1CCCCCCC1>>Cc1[nH]c2ccc(Cl)cc2c1C1CCN(CC2CCCCCCC2)CC1",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.COC(=O)Cc1ccccc1CN1CCCc2ccc(-c3cccc([C@@H](C)N)c3F)cc21.[Li+].[OH-]>>C[C@@H](N)c1cccc(-c2ccc3c(c2)N(Cc2ccccc2CC(=O)O)CCC3)c1F",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccc(S(=O)(=O)Cl)cc1.O=S(=O)([O-])O.[Na+].[OH-].c1ccc(CN(CCc2c[nH]c3ccccc23)Cc2ccccc2)cc1.c1ccccc1>>Cc1ccc(S(=O)(=O)n2cc(CCN(Cc3ccccc3)Cc3ccccc3)c3ccccc32)cc1",
        "output": "648"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.O=C1CCC2(CC1)Cc1ccc(Br)cc1C2=O.[BH4-].[Na+]>>O=C1c2cc(Br)ccc2CC12CCC(O)CC2",
        "output": "91"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1.Cl.Cl.Fc1ccccc1F.O=C(CCCCCBr)c1ccc(F)c(F)c1.O=C(Cl)CCCCCBr.O=C([O-])[O-].[K+].[K+]>>COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCC(=O)c2ccc(F)c(F)c2)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCCC[N+](CCCC)(CCCC)CCCC.FC(F)(F)c1ccccc1C(=S)N1CCNCC1.O=C(NCCC1CC1)c1ccc(Cl)nn1.O=C([O-])[O-].[I-].[K+].[K+]>>O=C(NCCC1CC1)c1ccc(N2CCN(C(=S)c3ccccc3C(F)(F)F)CC2)nn1",
        "output": "406"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C(=O)O)c1ccc(NC(=O)c2ccccc2)nc1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1.O.On1nnc2ccccc21>>CC(C(=O)NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1)c1ccc(NC(=O)c2ccccc2)nc1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(=O)O.COC(=O)c1ccccc1OCCC1(CCO)CCCCC1.ClCCl.Ic1ccccc1>>COC(=O)c1ccccc1OCCC1(CC=O)CCCCC1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(CCC(O)Cc1ccccc1)C(=O)OC(C)(C)C.N#Cc1ccc(Cl)cc1F>>CN(CCC(Cc1ccccc1)Oc1cc(Cl)ccc1C#N)C(=O)OC(C)(C)C",
        "output": "485"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCN(CCC)c1ccc([N+](=O)[O-])c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1.CO.[Pd]>>CCCN(CCC)c1ccc(N)c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COc1ccc(C(=O)O)c(O)c1.Nc1ccc(F)cc1F.O=S(Cl)Cl>>COc1ccc(C(=O)Nc2ccc(F)cc2F)c(O)c1",
        "output": "50"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.O.O=C(Cl)OCC1c2ccccc2-c2ccccc21.O=C([O-])[O-].O[C@H]1CO[C@H]2[C@@H]1NC[C@@H]2Cl.[Na+].[Na+]>>O=C(OCC1c2ccccc2-c2ccccc21)N1C[C@H](Cl)[C@H]2OC[C@H](O)[C@H]21",
        "output": "219"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[C@@H](N)CO.O=C(O)c1cc(OCC2CC2)c(Cl)cn1>>CC(C)(C)[C@H](CO)NC(=O)c1cc(OCC2CC2)c(Cl)cn1",
        "output": "137"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)C1(F)CCN(C(=O)OC(C)(C)C)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(C)OC(=O)N1CCC(F)(CO)CC1",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)OC(C)C.CC1(C)CC2(CCCN(C3CCN(C(=O)c4cc(Cl)nc5ccccc45)CC3)C2)C(=O)O1.OC1CCNCC1>>CC1(C)CC2(CCCN(C3CCN(C(=O)c4cc(N5CCC(O)CC5)nc5ccccc45)CC3)C2)C(=O)O1",
        "output": "220"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1ccccc1OCNC(=O)OC(C)(C)C.C[Si](C)(C)[O-].[K+]>>CC(C)(C)OC(=O)NCOc1ccccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O=C(O)CCn1cccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCn1cccc1",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(SCC(=O)NCCc2ccc(NS(=O)(=O)c3ccc(-c4ccccc4)cc3)cc2)cc1.O=C1Nc2ccccc2N[C@H]1Cc1ccccc1>>Nc1ccc(SCC(=O)NCCc2ccc(NS(=O)(=O)c3ccc(-c4ccccc4)cc3)cc2)cc1",
        "output": "782"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1cc(Cl)c(Cl)cc1O.O=[N+]([O-])c1cccc(Cl)c1O>>Nc1cccc(Cl)c1O",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CNC.c1ccc(CCCCCCc2ccccc2OCC2CO2)cc1>>CN(C)CC(O)COc1ccccc1CCCCCCc1ccccc1",
        "output": "76"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C=CCC(CC=C)(COc1cc(C)c(-c2ccc(C(F)(F)F)cc2)c(C)c1)c1ccc(C(=O)OC)s1.Cl.[Li+].[OH-]>>C=CCC(CC=C)(COc1cc(C)c(-c2ccc(C(F)(F)F)cc2)c(C)c1)c1ccc(C(=O)O)s1",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cccc2cc(C(=O)O)c(=O)oc12.F[P-](F)(F)(F)(F)F.Nc1cccc(-c2cccnc2)c1>>COc1cccc2cc(C(=O)Nc3cccc(-c4cccnc4)c3)c(=O)oc12",
        "output": "799"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "NCCc1ccc(CN2CCCC2)cc1.O=C(O)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1[N+](=O)[O-]>>O=C(NCCc1ccc(CN2CCCC2)cc1)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1[N+](=O)[O-]",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1CCCC1.Cl.Clc1nccc(-c2ccc(-c3cccs3)s2)n1.NCCn1c(=O)[nH]c2ccccc21.O=C([O-])[O-].[K+].[K+]>>O=c1[nH]c2ccccc2n1CCNc1nccc(-c2ccc(-c3cccs3)s2)n1",
        "output": "544"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCN=C=O.ClCCl.NCCO.O=C=O>>CCCCNC(=O)NCCO",
        "output": "244"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.Nc1ccc(Oc2ncnc3c2ncn3C2CCCCO2)cc1.O=C(Cc1ccccc1)N=C=S>>O=C(Cc1ccccc1)NC(=S)Nc1ccc(Oc2ncnc3c2ncn3C2CCCCO2)cc1",
        "output": "961"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NC1CCN(c2ncc(Br)cn2)CC1.CI.[H-].[Na+]>>CN(C(=O)OC(C)(C)C)C1CCN(c2ncc(Br)cn2)CC1",
        "output": "803"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1cc(O)c2cc(C(C)C)cc(Br)c2n1.COC(=O)c1cc(O)c2cccc(OCc3ccccc3)c2n1>>CC(C)c1cc(Br)c2nc(C(=O)O)cc(O)c2c1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCCCCC1CC1CC1CC1CCCCCCCC(=O)OC.CCOC(C)=O.[Cl-].[Li+].[NH4+].[OH-]>>CCCCCC1CC1CC1CC1CCCCCCCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "NCCCn1ccnc1.O=C(O)c1cccc(CS(=O)(=O)C=C2CN(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)C2)c1>>O=C(NCCCn1ccnc1)c1cccc(CS(=O)(=O)C=C2CN(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)C2)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC(O)C1.CN(C)C=O.CS(=O)(=O)c1nc(Cl)cc(N2CCOCC2)n1.[H-].[Na+]>>CC(C)(C)OC(=O)N1CC(Oc2nc(Cl)cc(N3CCOCC3)n2)C1",
        "output": "667"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C3(O)CNC3)n(C)c2n1.ClCCCl.ClCCl.O=C1CCOCC1.[Na+]>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C3(O)CN(C4CCOCC4)C3)n(C)c2n1",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CCO[C@@H]1C[C@H](N)c2cc(OCCC)ccc21.C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CC2CNCC2C1.ClCCCl.[Na+].[Na+].[OH-]>>CN1CC2CN(C(=O)OC(C)(C)C)CC2C1",
        "output": "217"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.C[O-].Cc1cccc(-c2[nH]c(C(C)C)nc2-c2cccc(-c3ccn(C(=O)OC(C)(C)C)c3)c2)n1.O.[Na+]>>Cc1cccc(-c2[nH]c(C(C)C)nc2-c2cccc(-c3cc[nH]c3)c2)n1",
        "output": "848"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc2c(Oc3cc(C)c(C)cc3C(C)=O)ccnc2cc1OCc1ccccc1.CS(=O)(=O)O.O=C(O)C(F)(F)F>>COc1cc2c(Oc3cc(C)c(C)cc3C(C)=O)ccnc2cc1O",
        "output": "23"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)COc1cccc(N2CCCC(NC(=O)OC(C)(C)C)C2)c1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)COc1cccc(N2CCCC(N)C2)c1",
        "output": "538"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CNC(=O)c1cn(C(C)c2ccc(C#N)cc2)c(C)c(Br)c1=O.O=C([O-])[O-].OB(O)c1cccc(C(F)F)c1.[K+].[K+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CNC(=O)c1cn(C(C)c2ccc(C#N)cc2)c(C)c(-c2cccc(C(F)F)c2)c1=O",
        "output": "833"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(C)(C)c1ccc(OCC(=O)O)c(C(C)(C)CC)c1.O=S(Cl)Cl>>CCC(C)(C)c1ccc(OCC(=O)Cl)c(C(C)(C)CC)c1",
        "output": "53"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCOCCOCCOCCOCCO1.Cc1ccccc1.O=[N+]([O-])c1ccc(-c2ccc(O)cc2)cc1.OCCCCCCI.[K]>>O=[N+]([O-])c1ccc(-c2ccc(OCCCCCCO)cc2)cc1",
        "output": "198"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.Cc1ccccc1.ClCCl.O=C(Cl)OCc1ccccc1.O[C@H]1CCNC1>>O=C(OCc1ccccc1)N1CC[C@H](O)C1",
        "output": "427"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1cccc(Br)c1.CCOCC.O=C1C2CCC1CN(Cc1ccccc1)C2.[Li]CCCC>>OC1(c2cccc(Br)c2)C2CCC1CN(Cc1ccccc1)C2",
        "output": "321"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CNCCNC.Cc1nc(Cl)c2nc(-c3ccccc3)cc-2[nH]1.O.O=C([O-])[O-].[K+].[K+]>>CNCCN(C)c1nc(C)[nH]c2cc(-c3ccccc3)nc1-2",
        "output": "505"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CO.CSCC[C@H](O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)C(=O)O.C[Si](C)(C)C=[N+]=[N-].Cc1ccccc1>>COC(=O)[C@H](CCSC)O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C",
        "output": "195"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.Nc1cc(Oc2ccc([N+](=O)[O-])cc2F)ncn1>>CC(C)(C)OC(=O)Nc1cc(Oc2ccc([N+](=O)[O-])cc2F)ncn1",
        "output": "849"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1ccc2c(ccn2Cc2ccccc2)c1.C1COCCO1.ClCCl.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccc(F)c(Cl)c1.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Fc1ccc(-c2ccc3c(ccn3Cc3ccccc3)c2)cc1Cl",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N1CCC2(C1)CN(C(=O)Nc1ncc(Cl)s1)c1ccc(C(C)O)cc12.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.O=S([O-])[O-].[Na+].[Na+]>>CC(=O)c1ccc2c(c1)C1(CCN(C(C)=O)C1)CN2C(=O)Nc1ncc(Cl)s1",
        "output": "32"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCCN(c2nc3ccccc3n2CCO)CC1.CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)N1CCCN(c2nc3ccccc3n2CCOS(C)(=O)=O)CC1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CNc1cc(C(=O)N2CCCC(c3ccc(C(F)(F)F)cc3)C2)ccn1.CNc1cc(C(=O)O)ccn1.CNc1cc(C(=O)O)ccn1.COc1ccccc1C1CCCNC1.Cl.Cl.Cl.O>>CNc1cc(C(=O)N2CCCC(c3ccccc3OC)C2)ccn1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)NC1CCc2[nH]c3cc(OCc4ccccc4)ccc3c2C1.CCO.Cl.[Pd]>>CC(=O)NC1CCc2[nH]c3cc(O)ccc3c2C1",
        "output": "23"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.Nc1nc2ccc(Oc3ccc(Cl)c(NC(=O)C(F)(F)F)c3)nc2s1.O=C(Cl)C1CC1.O=C([O-])O.[Na+].c1ccncc1>>O=C(Nc1nc2ccc(Oc3ccc(Cl)c(NC(=O)C(F)(F)F)c3)nc2s1)C1CC1",
        "output": "553"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CNC.CO.Fc1ccc(F)c(Br)n1.O.[Cl-].[Na+]>>CN(C)c1ccc(F)c(Br)n1",
        "output": "756"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.O=C(O)c1cccc2c1Cc1c-2[nH]c2ccc(Cl)cc12.O=S(=O)(O)O>>CCOC(=O)c1cccc2c1Cc1c-2[nH]c2ccc(Cl)cc12",
        "output": "33"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CNC.O=C(CBr)c1ccc(Cl)cc1Cl>>CN(C)CC(=O)c1ccc(Cl)cc1Cl",
        "output": "413"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C(=C1CCNCC1)c1ccc2ccccc2n1.CN(C)C=O.Cc1ccc(OCCCCl)c2c1NC(=O)C2(C)C.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>Cc1ccc(OCCCN2CCC(=Cc3ccc4ccccc4n3)CC2)c2c1NC(=O)C2(C)C",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CCNCCO.CN(C(=O)Oc1ccc(C(F)(F)F)cc1)[C@@H]1CC[C@@H](CCCOS(C)(=O)=O)CC1.[I-].[Na+]>>CCN(CCO)CCC[C@@H]1CC[C@@H](N(C)C(=O)Oc2ccc(C(F)(F)F)cc2)CC1",
        "output": "496"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CC#N.CCN(CC)CC.Cc1cc([N+](=O)[O-])ccc1F.ClCCl>>Cc1cc([N+](=O)[O-])ccc1N1CCOCC1",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "B.C1CCOC1.C1CCOC1.Cc1c(-c2ccnn2-c2ccc(C#N)cc2)c(=O)n(CCC(=O)O)c(=O)n1-c1cccc(C(F)(F)F)c1.[Cl-].[NH4+]>>Cc1c(-c2ccnn2-c2ccc(C#N)cc2)c(=O)n(CCCO)c(=O)n1-c1cccc(C(F)(F)F)c1",
        "output": "231"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(CCl)cc1.Cc1c(C)c2c(c(C)c1O)C(c1ccc(N(C)C)cc1)C(C)(C)O2>>COc1ccc(COc2c(C)c(C)c3c(c2C)C(c2ccc(N(C)C)cc2)C(C)(C)O3)cc1",
        "output": "49"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CN(C)C=O.COc1cc(P(C)(C)=O)ccc1N.Cl.Clc1ncc(Cl)c(Nc2ccccc2)n1>>COc1cc(P(C)(C)=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2)n1",
        "output": "808"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClCCl.OCc1ccc2[nH]ccc2c1.[Mn+2].[O-2]>>O=Cc1ccc2[nH]ccc2c1",
        "output": "179"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccc(C(=O)Nc2ccc(C(C)=O)cc2[N+](=O)[O-])cc1.CCO.O.O=C[O-].O=[Pt]=O.[NH4+]>>CC(=O)c1ccc(C(=O)Nc2ccc(C(C)=O)cc2N)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCN(CC(=O)OC)C(=O)C1Cc2c(n(Cc3ccc(F)cc3)c3ccccc23)CN1C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)CCN(CC(=O)OC)C(=O)C1Cc2c(n(Cc3ccc(F)cc3)c3ccccc23)CN1",
        "output": "634"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1cccc2ccc(O)cc12.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>COC(=O)c1cccc2ccc(OS(=O)(=O)C(F)(F)F)cc12",
        "output": "731"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.N#N.O=[N+]([O-])c1cc(C(F)(F)F)ccc1-n1cccn1.[Pd]>>Nc1cc(C(F)(F)F)ccc1-n1cccn1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)S(=O)(=O)c1ccc(N)cc1C#N.CCS(=O)(=O)c1ccc(NC(=O)CCCc2ccc(Br)cc2C)cc1C#N.O=C(Cl)CCCc1ccc(Br)cc1>>CC(C)S(=O)(=O)c1ccc(NC(=O)CCCc2ccc(Br)cc2)cc1C#N",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1.Cc1noc(CC2CCC(c3ncc(-c4ccc(N)cc4)s3)CC2)n1.O=C=Nc1ccccc1Cl>>Cc1noc(CC2CCC(c3ncc(-c4ccc(NC(=O)Nc5ccccc5Cl)cc4)s3)CC2)n1",
        "output": "473"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Fc1ccccc1N1CCNCC1.O=C(O)c1cccc(-c2noc(C(F)(F)F)n2)c1>>O=C(c1cccc(-c2noc(C(F)(F)F)n2)c1)N1CCN(c2ccccc2F)CC1",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(CO)(c2ccccc2)CC1.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.Cl.O.O=C(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CC(C)(C)OC(=O)N1CCC(COC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)CC[C@]1(C)C(=O)C(C2=NS(=O)(=O)c3cc(N)ccc3N2)=C(O)c2ccccc21.CC(C)=O.CS(=O)(=O)Cl.Cl.c1ccncc1>>CC(C)(C)CC[C@]1(C)C(=O)C(C2=NS(=O)(=O)c3cc(NS(C)(=O)=O)ccc3N2)=C(O)c2ccccc21",
        "output": "194"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CCCN.Nc1nc(Cl)nc(Cl)n1.[Na+].[OH-]>>CCCNc1nc(N)nc(Cl)n1",
        "output": "578"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.COC(=O)CCc1cnc(N)cn1.O=C1CCC(=O)N1Br>>COC(=O)CCc1cnc(N)c(Br)n1",
        "output": "665"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(C)C=O.Cl.Cl.Cl.N[C@@H]1CN2CCC1CC2.O.O=Cc1ccccc1C(F)(F)F.[Na+].[Na+].[OH-]>>FC(F)(F)c1ccccc1CN[C@@H]1CN2CCC1CC2",
        "output": "468"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)OC(Cn2ccc([N+](=O)[O-])n2)C(C)(C)O1.CCOC(C)=O.CO.NN.O.O.[Ni]>>CC1(C)OC(Cn2ccc(N)n2)C(C)(C)O1",
        "output": "684"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(C(=O)O)cc2)CC1.CC(C)(C)c1cccc(N)c1.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl>>CC(C)(C)OC(=O)N1CCN(c2ccc(C(=O)Nc3cccc(C(C)(C)C)c3)cc2)CC1",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COCCOC.Cc1cc2c(C(F)(F)F)cccc2n1S(=O)(=O)c1ccccc1.Cl.O.[Na+].[OH-]>>Cc1cc2c(C(F)(F)F)cccc2[nH]1",
        "output": "771"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CS(=O)(=O)O.Cl.NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O.O=C=Nc1ccc(SC(F)(F)F)cc1>>O=C1CCC(N2Cc3cc(CNC(=O)Nc4ccc(SC(F)(F)F)cc4)ccc3C2=O)C(=O)N1",
        "output": "814"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COCCNC(=O)[C@@H]1CC[C@@H](N)CC1.Cl.O=C(O)c1c[nH]c2c(-c3c(OCC4CCC4)ccc4c3OCO4)ncnc12>>COCCNC(=O)[C@@H]1CC[C@@H](NC(=O)c2c[nH]c3c(-c4c(OCC5CCC5)ccc5c4OCO5)ncnc23)CC1",
        "output": "737"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.COC(=O)CCCCCCCCC(=O)c1c(C)cc(OC)c(OC)c1O.[H][H].[Pd]>>COC(=O)CCCCCCCCCc1c(C)cc(OC)c(OC)c1O",
        "output": "92"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Nc1ccc(O)cc1.O=C(Cl)OCC(Cl)(Cl)Cl>>O=C(Nc1ccc(O)cc1)OCC(Cl)(Cl)Cl",
        "output": "102"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.CN1CCN(CCO)CC1.Cc1c(O)cn2ncnc(Oc3ccc([N+](=O)[O-])cc3F)c12.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1c(OCCN2CCN(C)CC2)cn2ncnc(Oc3ccc([N+](=O)[O-])cc3F)c12",
        "output": "547"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.O.O=C(Nc1ccon1)OCC(Cl)(Cl)Cl.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>O=C(Nc1ccon1)N1CCN(c2nc(-c3ccccc3)ns2)CC1",
        "output": "980"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(CC(C)(C)OOC(C)(C)C)OC(=O)Cl.CCOCC.CNC>>CC(CC(C)(C)OOC(C)(C)C)OC(=O)N(C)C",
        "output": "219"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C=C(C(=O)O)N(CC)S(=O)(=O)c1ccc(F)cc1.CCOC(=O)OC(=O)OCC.NCc1cc(-c2ccc(C(F)(F)F)cc2)nc(N2CCOCC2)c1>>C=C(C(=O)NCc1cc(-c2ccc(C(F)(F)F)cc2)nc(N2CCOCC2)c1)N(CC)S(=O)(=O)c1ccc(F)cc1",
        "output": "549"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cccc2cc(C(=O)O)c(=O)oc12.COc1cncc(-c2cccc(N)c2)c1.F[P-](F)(F)(F)(F)F>>COc1cncc(-c2cccc(NC(=O)c3cc4cccc(OC)c4oc3=O)c2)c1",
        "output": "799"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(C)=O.Cc1cccc(Cl)c1N=C=O.Nc1cc2ccccc2cc1C(=O)O.O>>Cc1cccc(Cl)c1NC(=O)Nc1cc2ccccc2cc1C(=O)O",
        "output": "473"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CN.O=Cc1ccc(Oc2cnc(C(F)(F)F)nc2)cc1>>CNCc1ccc(Oc2cnc(C(F)(F)F)nc2)cc1",
        "output": "468"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1ccc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)cc1OCC.Cl.[Na+].[OH-]>>CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(=O)O",
        "output": "5"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCCC(N)CC1.CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)O.ClCCCl.ClCCl>>CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CCCN(C(=O)OC(C)(C)C)CC1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)CCCNc1ccc(OC)cc1.COc1cc(C(=O)N(CCCCCC(=O)O)C(C)(C)C)cc(OC)c1OC.[K+].[OH-]>>COc1ccc(NCCCC(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(CCCN)OCC.CO.COC(OC)OC.N#Cc1ccc(C=O)cc1.[BH4-].[Na+]>>CCOC(CCCNCc1ccc(C#N)cc1)OCC",
        "output": "468"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)O.CC(C)C[C@H](N)C(=O)OCc1ccccc1.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.O.On1nnc2ccccc21>>CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1",
        "output": "132"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COc1ccc(CS(=O)c2cc(OC)c(OC)c(OC)c2)cc1[N+](=O)[O-].[Pd]>>COc1ccc(CS(=O)c2cc(OC)c(OC)c(OC)c2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cccc(CN)c1OC.O=C(O)c1cc([N+](=O)[O-])c(Sc2c(Cl)cncc2Cl)s1>>COc1cccc(CNC(=O)c2cc([N+](=O)[O-])c(Sc3c(Cl)cncc3Cl)s2)c1OC",
        "output": "950"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(C)=O.Nc1cc(Cl)c(I)cc1[N+](=O)[O-].O.[Cl-].[Fe].[NH4+]>>Nc1cc(Cl)c(I)cc1N",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCOc1ccc(C#Cc2ccccc2)cc1C(=O)O.CN(C)C=O.ClCCCl.N[C@@H](CO)Cc1c[nH]c2ccccc12.O.O.On1nnc2ccccc21>>CCCOc1ccc(C#Cc2ccccc2)cc1C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.COC(=O)CBr.O.O=C([O-])[O-].O=Cc1c(Cl)cc(O)cc1Cl.[K+].[K+]>>COC(=O)COc1cc(Cl)c(C=O)c(Cl)c1",
        "output": "557"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(C)=O.N#Cc1c(F)cc(Br)cc1F.N[C@H]1CCOC1.O>>N#Cc1c(F)cc(Br)cc1N[C@H]1CCOC1",
        "output": "572"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)Cc1ccc(F)c(Br)c1>>COC(=O)Cc1ccc(F)c(B2OC(C)(C)C(C)(C)O2)c1",
        "output": "942"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CI.CN(C)C=O.CN(C)CCc1c[nH]c2c(F)ccc(OCc3ccccc3)c12.[H-].[Na+]>>CN(C)CCc1cn(C)c2c(F)ccc(OCc3ccccc3)c12",
        "output": "191"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCC.COc1ccc(F)c(C#N)c1>>N#Cc1cc(O)ccc1F",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1ccc(Cn2nc(-c3cc(F)c(F)c(F)c3)cc2C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1ccc(Cn2nc(-c3cc(F)c(F)c(F)c3)cc2C(=O)O)cc1",
        "output": "569"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CO.Clc1ncc(Cl)c(Cl)n1.NCC1CCCO1>>Clc1ncc(Cl)c(NCC2CCCO2)n1",
        "output": "166"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(O)c1cncc(Br)c1.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.[Ca+2].[OH-].[OH-]>>CC(C)(O)c1cc(Br)c[n+]([O-])c1",
        "output": "262"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)O.COc1cc2c(Cl)c(C#N)cnc2c(OC)c1OC.Cc1ccc(N)cc1O.O.O=C([O-])[O-].[Na+].[Na+]>>COc1cc2c(Nc3ccc(C)c(O)c3)c(C#N)cnc2c(OC)c1OC",
        "output": "115"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(=O)N1c2ccc(Br)c(Oc3ccccc3F)c2CC[C@@H]1C.CC(C)(C)OC(=O)N1CCC(n2cc(B3OC(C)(C)C(C)(C)O3)cn2)CC1.Cl[Pd]Cl.O.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(=O)N1c2ccc(-c3cnn(C4CCN(C(=O)OC(C)(C)C)CC4)c3)c(Oc3ccccc3F)c2CC[C@@H]1C",
        "output": "971"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "NCCn1ccnc1.O=S(=O)(Cl)c1ccc(Br)cc1>>O=S(=O)(NCCn1ccnc1)c1ccc(Br)cc1",
        "output": "43"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCCc1c(O)ccc(C(C)=O)c1O.CCCc1c(OCCCC(=O)OCC)ccc(C(C)=O)c1OCCOCCOCCOCCBr.O=C([O-])[O-].[K+].[K+]>>CCCc1c(OCCOCCOCCOCCOc2c(C(C)=O)ccc(OCCCC(=O)OCC)c2CCC)ccc(C(C)=O)c1O",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC(CC(C(=O)OC(C)(C)C)n1cc(OC)c(-c2cc(Cl)ccc2C#N)cc1=O)OC.O=C(O)C(F)(F)F>>CCC(CC(C(=O)O)n1cc(OC)c(-c2cc(Cl)ccc2C#N)cc1=O)OC",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Cl.CC(C)(C)C(=O)C(C(O)C(Cl)(Cl)Cl)n1cncn1.CN(C)C=O>>CC(=O)OC(C(C(=O)C(C)(C)C)n1cncn1)C(Cl)(Cl)Cl",
        "output": "126"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C[C@H]1CCCN[C@H]1CNc1ccc(C(F)(F)F)cn1.O=C(O)c1ccccc1Oc1ccccc1>>C[C@H]1CCCN(C(=O)c2ccccc2Oc2ccccc2)[C@H]1CNc1ccc(C(F)(F)F)cn1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1cc(Nc2ncc3c(n2)CCNC3)cc(OC)c1OC.F[P-](F)(F)(F)(F)F.O=C(O)c1ccccn1>>COc1cc(Nc2ncc3c(n2)CCN(C(=O)c2ccccn2)C3)cc(OC)c1OC",
        "output": "605"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)N(CCCl)C(C)C.CN(C)CCCOc1ccc(-c2cnc(Nc3ccccc3)s2)cc1.CO.Cl.ClCCl.Oc1ccc(Nc2ncc(-c3ccsc3)s2)c(C(F)(F)F)c1>>CC(C)N(CCOc1ccc(Nc2ncc(-c3ccsc3)s2)c(C(F)(F)F)c1)C(C)C",
        "output": "74"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1ccc(-c2nocc2C(=O)O)cc1.Cl.Cl.F[B-](F)(F)F.OC1(c2cccnc2)CCNC1>>COc1ccc(-c2nocc2C(=O)N2CCC(O)(c3cccnc3)C2)cc1",
        "output": "975"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.NN.O.O=[N+]([O-])c1c(CS(=O)(=O)c2ccccc2)cc(F)cc1OCCCl.[Pd]>>Nc1c(CS(=O)(=O)c2ccccc2)cc(F)cc1OCCCl",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCc1c(C)[nH]c(C(=O)O)c1CC.Cl.NC(=O)c1cc(Cl)nc(N2CCC(N)CC2)c1>>CCc1c(C)[nH]c(C(=O)NC2CCN(c3cc(C(N)=O)cc(Cl)n3)CC2)c1CC",
        "output": "137"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cccc2c(CCN)c[nH]c12.O=CC1CC1>>Cc1cccc2c(CCNCC3CC3)c[nH]c12",
        "output": "426"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1ccc2c(OCC(=O)O)ccnc2c1.ClCCCl.NNc1ccc(Cl)nn1.On1nnc2cccnc21>>COc1ccc2c(OCC(=O)NNc3ccc(Cl)nn3)ccnc2c1",
        "output": "459"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C1NCCn2c1cc1cc(F)c(F)c(Br)c12.OB(O)c1ccc(F)cc1>>O=C1NCCn2c1cc1cc(F)c(F)c(-c3ccc(F)cc3)c12",
        "output": "833"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CNCCN1.COc1ccc2ccc(OCCO)cc2c1.COc1ccc2ccc(OCCOc3cncc(Cl)n3)cc2c1.O=C([O-])[O-].[K+].[K+]>>COc1ccc2ccc(OCCOc3cncc(N4CCNCC4)n3)cc2c1",
        "output": "505"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1c(C(=O)O)ccn1Cc1ccccc1.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.ClCCl.NCc1ccc(F)c(F)c1>>CC(C)c1c(C(=O)NCc2ccc(F)c(F)c2)ccn1Cc1ccccc1",
        "output": "790"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC1CCNC(C)CC1.Cl.Fc1c(Cl)ncnc1Cl.O=C([O-])[O-].[Cl-].[NH4+]>>CC1CCC(C)N(c2ncnc(Cl)c2F)CC1",
        "output": "296"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(F)c2c1C(=O)c1ccncc1C2=O.ClCCl.O.[Al+3].[Cl-].[Cl-].[Cl-].[Cl-].[Na+]>>O=C1c2ccncc2C(=O)c2c(F)ccc(O)c21",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(=O)O[Cu]OC(C)=O.O=C([O-])[O-].O=S1(=O)CCN2CCC[C@@H](c3ccc(O)cc3)C2=N1.OB(O)c1ccc(Br)cc1.[Ca+2].[Cl-].[Cl-].[Cs+].[Cs+].c1ccncc1>>O=S1(=O)CCN2CCC[C@@H](c3ccc(Oc4ccc(Br)cc4)cc3)C2=N1",
        "output": "920"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(N)c1ccccc1.CCOC(C)=O.O=C=Nc1ccc([N+](=O)[O-])cc1>>CC(NC(=O)Nc1ccc([N+](=O)[O-])cc1)c1ccccc1",
        "output": "814"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.COC(=O)Cl.ClCCl.Oc1ccc(F)cc1C1CCCC1>>COC(=O)Oc1ccc(F)cc1C1CCCC1",
        "output": "261"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(N)CN.CN(C)C=O.CN(C)[C+](On1nnc2ccccc21)N(C)C.CN1CCOCC1.Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)O.F[B-](F)(F)F>>Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NCC(C)(C)N",
        "output": "697"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.NC(=O)c1ccccc1.NC(=O)c1ccccc1[N+](=O)[O-]>>NC(=O)c1ccccc1N",
        "output": "486"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1c(C)nc2cccc(OC[C@@H](N)CC)c2c1N.COc1cc(C(=O)O)ccc1OCCO>>CCOC(=O)c1c(C)nc2cccc(OC[C@H](CC)NC(=O)c3ccc(OCCO)c(OC)c3)c2c1N",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(CN1C(=O)c2ccccc2C1=O)OCC.Cl>>O=CCN1C(=O)c2ccccc2C1=O",
        "output": "409"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN(C)CC(=O)O.COc1cc2c(Nc3c(Cl)cnc4c3OCO4)ncnc2cc1OCC1CCNCC1>>COc1cc2c(Nc3c(Cl)cnc4c3OCO4)ncnc2cc1OCC1CCN(C(=O)CN(C)C)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CN(C)c1ccncc1.Nc1nc2ccc(Oc3cc(NC(=O)C(F)(F)F)c(F)cc3Cl)nc2s1.c1ccncc1>>CC(=O)Nc1nc2ccc(Oc3cc(NC(=O)C(F)(F)F)c(F)cc3Cl)nc2s1",
        "output": "553"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cc2cc(Br)ccc2n1Cc1ccc(C)cc1.Cc1cccc(B(O)O)c1>>CCOC(=O)c1cc2cc(-c3cccc(C)c3)ccc2n1Cc1ccc(C)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNCC1.CC#N.CC(C)C[C@@H](C#N)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1cc2ccccc2n1CCCCl.O.[I-].[Na+]>>CC(C)C[C@@H](C#N)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1cc2ccccc2n1CCCN1CCCCC1",
        "output": "138"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.COCCl.O.O=C([O-])[O-].O=Cc1ccc(O)cc1O.[Cs+].[Cs+]>>COCOc1ccc(C=O)c(O)c1",
        "output": "375"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(C)=O.N#CCc1cccc(Oc2ccccc2)c1.O=C([O-])[O-].OO.[K+].[K+]>>NC(=O)Cc1cccc(Oc2ccccc2)c1",
        "output": "632"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)ncn1.Cl.O.[Na+].[OH-]>>O=C(O)c1cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)ncn1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.FC1(F)CCNCC1.Fc1ccc(C2CCc3c(Cl)nc(Cl)nc32)cc1>>Fc1ccc(C2CCc3c2nc(Cl)nc3N2CCC(F)(F)CC2)cc1",
        "output": "162"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)c1cc(NC(=O)Nc2cccc(O)c2)no1.CC(C)O.Clc1ncnc2ccc(I)cc12.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3ncnc4ccc(I)cc34)c2)no1",
        "output": "890"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.COc1ccc(CNc2cc(F)ccc2N)c(OC)c1.O.O=[N+]([O-])c1cnc(Cl)nc1N[C@@H]1CCOc2c(F)cccc21.[Cl-].[Na+]>>COc1ccc(CNc2cc(F)ccc2Nc2ncc([N+](=O)[O-])c(N[C@@H]3CCOc4c(F)cccc43)n2)c(OC)c1",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CN(CCN(C)c1nc2cc([N+](=O)[O-])ccc2[nH]1)C(=O)c1ccccc1.Cl[Sn]Cl.O.O.[Na+].[OH-]>>CN(CCN(C)c1nc2cc(N)ccc2[nH]1)C(=O)c1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)c1ccc(NCc2cnn(Cc3ccccc3)c2)cc1.O=C(O)C1CCCc2ccccc21>>CC(C)c1ccc(N(Cc2cnn(Cc3ccccc3)c2)C(=O)C2CCCc3ccccc32)cc1",
        "output": "315"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.Cc1cc(Oc2ccc([N+](=O)[O-])cn2)c(Cl)cc1Br.[Pt]>>Cc1cc(Oc2ccc(N)cn2)c(Cl)cc1Br",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)N.CCCc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>CCCc1ccc(S(=O)(=O)NC(C)(C)C)cc1",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CCC(O)C=Cc1cccnc1.CC(=O)OC(C)=O.CCOCC.CN(C)c1ccccn1.c1ccncc1>>C#CCC(C=Cc1cccnc1)OC(C)=O",
        "output": "155"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1c(CCN2CCC([NH3+])CC2)ccc2c1COC2=O.O=C(O)c1ccc(-n2cccn2)cc1.[Cl-]>>Cc1c(CCN2CCC(NC(=O)c3ccc(-n4cccn4)cc3)CC2)ccc2c1COC2=O",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.Clc1ccc(CC2CCNCC2)cc1.O=C(O)c1cc(=O)c2cc(O)ccc2[nH]1>>O=C(c1cc(=O)c2cc(O)ccc2[nH]1)N1CCC(Cc2ccc(Cl)cc2)CC1",
        "output": "605"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.ClCCl.NC1CCCC1.O=C(CBr)c1ccc(S(=O)(=O)Cl)cc1>>O=C(CBr)c1ccc(S(=O)(=O)NC2CCCC2)cc1",
        "output": "43"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClC(Cl)Cl.[Mn+4].[O-2].[O-2].[O-][n+]1cc2c(cc1CO)OCCO2>>O=Cc1cc2c(c[n+]1[O-])OCCO2",
        "output": "263"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)c1cccc(C(C)C)c1N=C=O.CCCCC(CN)c1ccc2c(c1)OCO2.CCCCCC>>CCCCC(CNC(=O)Nc1c(C(C)C)cccc1C(C)C)c1ccc2c(c1)OCO2",
        "output": "35"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccccc1.II.O.O=S(=O)(O)O.O=S([O-])O.[Na+].[O-][I+3]([O-])([O-])O>>CC(C)S(=O)(=O)N[C@@H]1CCC[C@@H]1c1ccc(I)cc1",
        "output": "372"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=O.CC#N.CCN(CC)CC.Cl.Oc1ccc(I)cc1.[Cl-].[Cl-].[Mg+2]>>O=Cc1cc(I)ccc1O",
        "output": "451"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Nc1c(Cl)ccc(C)c1Cl.CC(=O)O.CCCO.Cl.O.[Cl-]>>Cc1ccc(Cl)c(N)c1Cl",
        "output": "66"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCc1nc2cnc3ccccc3c2n1NCc1ccco1.CO.Cc1ccc(S(=O)(=O)Cl)cc1.ClC(Cl)Cl.ClCCl.O.O=C(OO)c1cccc(Cl)c1.[NH4+].[OH-]>>CCOCc1nc2c(N)nc3ccccc3c2n1NCc1ccco1",
        "output": "959"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1c([C@@H](O)CN2C3CCC2C2CCC3N2)ccc2c1COC2=O.Cc1nc(C2CO2)ccc1C#N.Cl>>Cc1nc(C(O)CN2C3CCC2C2CCC3N2C[C@H](O)c2ccc3c(c2C)COC3=O)ccc1C#N",
        "output": "76"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cl.O.O=[N+]([O-])c1ccc(S(=O)(=O)Nc2nnc(-c3ccccc3)s2)cc1.[Fe]>>Nc1ccc(S(=O)(=O)Nc2nnc(-c3ccccc3)s2)cc1",
        "output": "401"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCC(C)(C#N)c1cccc(Br)c1.Cc1ccccc1.[AlH3]>>CCC(C)(CN)c1cccc(Br)c1",
        "output": "246"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCCCCC.CCOC(=O)CCc1cn(-c2ccc(C(F)(F)F)cn2)nc1C(C)C.Cl.[H-]>>CC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Fc1ccc2[nH]c3c(c2c1)CC1(CC3)OCCO1.O.O=CO>>O=C1CCc2[nH]c3ccc(F)cc3c2C1",
        "output": "251"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)c1ccc(B(O)O)cc1.CCO.Cc1ccccc1.O.O=C([O-])[O-].O=C1CCc2c(Br)cccc21.OCCO.[Na+].[Na+].[Pd+2]>>CC(C)(C)c1ccc(-c2cccc3c2CCC3=O)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrBr.CC(=O)O.C[C@H](NC(=O)c1c(N)ccnc1Cl)c1ccc(F)c(F)c1.N>>C[C@H](NC(=O)c1c(Cl)ncc(Br)c1N)c1ccc(F)c(F)c1",
        "output": "292"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(-n2sccc2=O)cc1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>O=c1ccsn1-c1ccc(CBr)cc1",
        "output": "29"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CCOC(C)=O.Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N3CCC(=O)N(CC(=O)N4CCN(C(=O)OC(C)(C)C)CC4)c4ccccc43)cc2)cc1.Cl>>Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N3CCC(=O)N(CC(=O)N4CCNCC4)c4ccccc43)cc2)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCN(CC)CC.CCc1cc(C(=O)OC)cc[n+]1[O-].CN(C)C(=O)Cl.C[Si](C)(C)C#N>>CCc1cc(C(=O)OC)cc(C#N)n1",
        "output": "720"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.CCOC(C)=O.Cc1ncn(-c2ccc(Br)cc2F)n1.N.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[C-]#N.[C-]#N.[Fe+2].[Pd].[Pd].[Zn+2].[Zn].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1ncn(-c2ccc(C#N)cc2F)n1",
        "output": "65"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.N#Cc1ccc(O)c(C(F)(F)F)c1.O.O=[N+]([O-])c1ccc(Cl)nc1>>N#Cc1ccc(Oc2ccc([N+](=O)[O-])cn2)c(C(F)(F)F)c1",
        "output": "516"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CN1CCNCC1.O=C(O)c1ccc(-n2nc(-c3ccccc3O)nc2-c2ccccc2O)cc1>>CN1CCN(C(=O)c2ccc(-n3nc(-c4ccccc4O)nc3-c3ccccc3O)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COc1ccc(C(=O)Cl)cc1SC1CCCC1.Nc1c(Cl)cncc1Cl.[Cl-].[H-].[NH4+].[Na+]>>COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)cc1SC1CCCC1",
        "output": "11"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(CCc4ccccc4)c3)c3cc(-c4ccc(N5CCN(C)CC5)cc4)cnc32)cc1.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4ccc(C5CCNCC5)cc4)cnc32)cc1.Cl.O.[Li+].[OH-]>>CN1CCN(c2ccc(-c3cnc4[nH]cc(-c5cnn(CCc6ccccc6)c5)c4c3)cc2)CC1",
        "output": "949"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COc1ccc(C(C)=CBr)cc1F.Cc1ccc2[nH]c3c(c2c1)CCN(C)C3.O=C(O)[C@@H]1CCCN1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>COc1ccc(C(C)=Cn2c3c(c4cc(C)ccc42)CCN(C)C3)cc1F",
        "output": "987"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=CCC/C(C)=C/COc1ccc(C(=O)O)cc1OC/C=C(\\C)CCC=C(C)C.CCN1CCCC1CN>>CCN1CCCC1CNC(=O)c1ccc(OC/C=C(\\C)CCC=C(C)C)c(OC/C=C(\\C)CCC=C(C)C)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(=O)OC(C)=O.CCC(C)C(NC(=O)C1CCCCN1C)C(=O)N(COC(=O)CC(C)C)C(CC(O)c1nc(C(=O)NCCCC(=O)O)cs1)C(C)C.O.c1ccncc1>>CCC(C)C(NC(=O)C1CCCCN1C)C(=O)N(COC(=O)CC(C)C)C(CC(OC(C)=O)c1nc(C(=O)NCCCC(=O)O)cs1)C(C)C",
        "output": "254"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)COc1cc(OC)c(SCCC(=O)N(C)c2ccccn2)cc1C.Cl.O=C([O-])O.O=P(Cl)(Cl)Cl.[BH4-].[Na+].[Na+]>>COC(=O)COc1cc(OC)c(SCCCN(C)c2ccccn2)cc1C",
        "output": "112"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.CS(=O)(=O)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1.C[O-].[Na+]>>COc1cc([N+](=O)[O-])cc(S(C)(=O)=O)c1",
        "output": "499"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)n1nnc(-c2cccc([N+](=O)[O-])c2)n1.CCO.[Cl-].[NH4+].[Zn]>>CC(C)n1nnc(-c2cccc(N)c2)n1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(N)(=O)=O.O=C(O)c1cnn2c(NCc3ccccc3)c(C(=O)N3CCC(c4ccccc4F)CC3)cnc12>>CS(=O)(=O)NC(=O)c1cnn2c(NCc3ccccc3)c(C(=O)N3CCC(c4ccccc4F)CC3)cnc12",
        "output": "991"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C)(C)c1ccc(CCOS(C)(=O)=O)cc1.CCOCCn1c(C2CCNCC2)nc2ccccc21.CO.O.O=C([O-])[O-].[Na+].[Na+]>>CCOCCn1c(C2CCN(CCc3ccc(C(C)(C)C(=O)OCC)cc3)CC2)nc2ccccc21",
        "output": "496"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)C=O.NCc1ccccc1N>>CC(C)(C)OC(=O)NCc1ccccc1N",
        "output": "686"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(=O)(=O)Cl.Cl.Cl.Nc1ccc(B(O)O)cc1.O=C([O-])O.[Na+]>>CS(=O)(=O)Nc1ccc(B(O)O)cc1",
        "output": "194"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.COc1cncc(Cl)c1.OO>>COc1cc(Cl)c[n+]([O-])c1",
        "output": "396"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=[N+]=[N-].CN(C)CCC(=NNC1=Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1)C(=O)O>>COC(=O)C(CCN(C)C)=NNC1=Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1",
        "output": "60"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1cc(N)n(-c2cnn(CCOC3CCCCO3)c2)n1.CCOC(C)=O.O.O=C(Cl)OCC(Cl)(Cl)Cl.[Na+].[OH-]>>CC(C)(C)c1cc(NC(=O)OCC(Cl)(Cl)Cl)n(-c2cnn(CCOC3CCCCO3)c2)n1",
        "output": "700"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1C(=O)c2cc([N+](=O)[O-])ccc2OC1(C)C.CO.[Pd]>>CC1C(=O)c2cc(N)ccc2OC1(C)C",
        "output": "202"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCOC(=O)CN1CC(c2ccccc2OC)c2cc(Cl)ccc2C(CC(C)C)C1=O.Cl.O.[Na+].[OH-]>>COc1ccccc1C1CN(CC(=O)O)C(=O)C(CC(C)C)c2ccc(Cl)cc21",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2cc(-c3ccc(OCc4c(-c5c(Cl)cncc5Cl)noc4C4CC4)cc3)ccc2n1.Cl.[Na+].[OH-]>>O=C(O)c1ccc2cc(-c3ccc(OCc4c(-c5c(Cl)cncc5Cl)noc4C4CC4)cc3)ccc2n1",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(NS(=O)(=O)c2ccc(N3CCC(=O)CC3)cc2)cc1OC.NC[C@H](O)COc1ccc(O)cc1>>COc1ccc(NS(=O)(=O)c2ccc(N3CCC(NC[C@H](O)COc4ccc(O)cc4)CC3)cc2)cc1OC",
        "output": "236"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCC(CO)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(=O)OC>>CCC(C=O)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(=O)OC",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCC2=NCCCN2CC1.Clc1cc(Cl)ncn1.O=C(NCCN1CCOCC1)c1cccc2cc(O)ccc12.O=C(NCCN1CCOCC1)c1cccc2cc(Oc3ccnc(Cl)n3)ccc12>>O=C(NCCN1CCOCC1)c1cccc2cc(Oc3cc(Cl)ncn3)ccc12",
        "output": "668"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(=O)Cl)c1ccccc1.Oc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1>>CCN(C(=O)Oc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1)c1ccccc1",
        "output": "425"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Br.CC(=O)O.COc1ccc2cc(-c3csc(Cc4c(Cl)cccc4Cl)n3)ccc2c1>>Oc1ccc2cc(-c3csc(Cc4c(Cl)cccc4Cl)n3)ccc2c1",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=C(Cn1ccnc1)CS(=O)(=O)c1ccccc1.[Na]>>O=S(=O)(CC(O)Cn1ccnc1)c1ccccc1",
        "output": "91"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.CO.ClCc1cccc(OCc2ccc3ccccc3n2)c1.N#Cc1cc2cc(O)ccc2[nH]c1=O.O=C([O-])[O-].[Br-].[K+].[K+]>>N#Cc1cc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc2[nH]c1=O",
        "output": "49"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C(C)(C)Br.CN(C)C=O.Cc1cc2c(cc1O)C(C)(C)CC1(CC(C)(C)c3cc(O)c(C)cc3O1)O2.Cl.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C(C)(C)Oc1cc2c(cc1C)OC1(CC(C)(C)c3cc(O)c(C)cc3O1)CC2(C)C",
        "output": "305"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CCOC(C)=O.O=[N+]([O-])c1cnc2ccc(Cl)c(F)c2c1Br.[Fe]>>Nc1cnc2ccc(Cl)c(F)c2c1Br",
        "output": "269"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.CC(C)I.COC(=O)Cc1ccc(C#Cc2cc(O)c3c(c2)C(C)(C)CC(C)(C)O3)cc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)Cc1ccc(C#Cc2cc(OC(C)C)c3c(c2)C(C)(C)CC(C)(C)O3)cc1",
        "output": "318"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COc1cc2ncnc(Oc3cccc(N)c3)c2cc1OC.O=C=Nc1ccc(Cl)cc1>>COc1cc2ncnc(Oc3cccc(NC(=O)Nc4ccc(Cl)cc4)c3)c2cc1OC",
        "output": "473"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CC2CNCCN2C1.O=C(O)c1ccc2c(c1)cc(C(=O)N1CCOCC1)n2CC(F)(F)F>>O=C(c1ccc2c(c1)cc(C(=O)N1CCOCC1)n2CC(F)(F)F)N1CCN2CCCC2C1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "NCCN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1.Nc1cccc(C(=O)O)c1>>Nc1cccc(C(=O)NCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.ClCCl.NCCc1ccc(Br)cc1.O=C(Cl)c1ccccc1C(F)(F)F>>O=C(NCCc1ccc(Br)cc1)c1ccccc1C(F)(F)F",
        "output": "271"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(C)cc(-c2c(-c3ccnc(-c4ccc(C(C)=O)cc4)c3)cnn2CC#N)c1.CSC.ClCCl.FB(F)F>>CC(=O)c1ccc(-c2cc(-c3cnn(CC#N)c3-c3cc(C)cc(O)c3)ccn2)cc1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(N)(C#N)Cn1nc2c(Cl)cc(Cl)c(Cl)c2n1.O=C(Cl)c1ccc(C(F)(F)F)cc1F>>CC(C#N)(Cn1nc2c(Cl)cc(Cl)c(Cl)c2n1)NC(=O)c1ccc(C(F)(F)F)cc1F",
        "output": "271"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrC(Br)(Br)Br.CN(C)C=O.COCCOCN(c1noc(C)c1C)S(=O)(=O)c1ccccc1-c1ccc(-c2ncco2)cc1CO.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COCCOCN(c1noc(C)c1C)S(=O)(=O)c1ccccc1-c1ccc(-c2ncco2)cc1CBr",
        "output": "750"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN1c2ncc(C(=O)OC)cc2NC(=O)[C@@H]1C.[Al+3].[H-].[H-].[H-].[H-].[H-].[Li+].[Na+]>>CCN1c2ncc(CO)cc2NC(=O)[C@@H]1C",
        "output": "522"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)N(C)c1cc(Br)cc(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1.CCO.Cl.Cl[Sn]Cl.O.O>>CC(=O)N(C)c1cc(Br)cc(S(=O)(=O)c2ccc(N)cc2)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C(O)CCCc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>O=C(CCCc1ccc(O)cc1)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)c1cc([N+](=O)[O-])cc(Cl)c1Sc1nc2cc(C(F)(F)F)ccc2s1.Cl[Sn](Cl)(Cl)Cl.O.O>>CC(=O)c1cc(N)cc(Cl)c1Sc1nc2cc(C(F)(F)F)ccc2s1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1ccc(Br)n1C.COCCOC.ClCCl.O=C([O-])[O-].OB(O)c1ccccc1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1ccc(-c2ccccc2)n1C",
        "output": "869"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCOC(C)=O.O=C(O)CCC(=O)c1ccc(-c2ccc(Cl)cc2)cc1.O=P(O)(O)O.[H][H].[Pd]>>O=C(O)CCCc1ccc(-c2ccc(Cl)cc2)cc1",
        "output": "92"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCn1ccc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)O)cc4)cc3)nc21.CN(C)C1CCNCC1>>CCn1ccc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)N5CCC(N(C)C)CC5)cc4)cc3)nc21",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1ccc2c(cnn2C)c1.CCOC(C)=O.O=C([O-])O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+]>>Cn1ncc2cc(CO)ccc21",
        "output": "311"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.ClCCl.O.O=C1C=CC[C@@H](CO)C1>>CC(=O)OC[C@@H]1CC=CC(=O)C1",
        "output": "126"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](CN)C1.CCN(CC)CC.CS(C)=O.O.O=[N+]([O-])c1cccnc1Cl>>CC(C)(C)OC(=O)N1CC[C@@H](CNc2ncccc2[N+](=O)[O-])C1",
        "output": "70"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(C)C=O.COc1cc(-c2ccccc2)c(-c2ccc(C=O)cc2)nn1.[Na+].c1ccc(-c2cc(C3CCNCC3)n[nH]2)nc1>>COc1cc(-c2ccccc2)c(-c2ccc(CN3CCC(c4cc(-c5ccccn5)[nH]n4)CC3)cc2)nn1",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC#N.CCO.CN=S(C)(=O)c1ccc(CN2C(=O)c3ccccc3C2=O)cc1.NCCN>>CN=S(C)(=O)c1ccc(CN)cc1",
        "output": "418"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCc1ccccc1.CCCCCC.CN(C)C=O.Cc1cc2cc([N+](=O)[O-])ccc2[nH]1.O.[H-].[Na+]>>Cc1cc2cc([N+](=O)[O-])ccc2n1Cc1ccccc1",
        "output": "528"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)Oc1ccc(C#Cc2ccccc2)cc1C(=O)O.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)C(C)(N)Cc1c[nH]c2ccccc12.O.On1nnc2ccccc21>>COC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)c1cc(C#Cc2ccccc2)ccc1OC(C)C",
        "output": "652"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COCOc1ccc(C2(C)COc3cc(OCOC)ccc3C2CCCCCCCCO)cc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O.c1ccncc1>>COCOc1ccc(C2(C)COc3cc(OCOC)ccc3C2CCCCCCCCOS(=O)(=O)c2ccc(C)cc2)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COc1cc2ncnc(N3CCN(C(=O)Nc4ccc([N+](=O)[O-])cc4)CC3)c2cc1OC.O.[C].[H][H].[Pd]>>COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(N)cc4)CC3)c2cc1OC",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC.CN(C)C=O.Cl.Clc1cc(Br)cc(Cl)c1CBr.O=C1NCCC12CCCCC2.[H-].[Na+]>>O=C1N(Cc2c(Cl)cc(Br)cc2Cl)CCC12CCCCC2",
        "output": "774"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCc1cc(CBr)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2.CCOC(C)=O.CO.CS(C)=O.ClC(Cl)Cl.O=S(=O)([O-])O.[C-]#N.[K+].[NH4+].[Na+].[OH-]>>CCCc1cc(CC#N)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2",
        "output": "39"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCCCCCCCCC#N.O.[Na+].[OH-]>>CCCCCCCCCCCCCCCCCCN",
        "output": "246"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccccc1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)[O-].Cc1ccccc1.[Na+].[Pd+2].c1ccc(-c2ccc3c(c2)c2ccc(-c4cccc5c4[nH]c4c(-c6nc(-c7ccccc7)nc(-c7ccccc7)n6)cccc45)cc2n3-c2ccccc2)cc1>>c1ccc(-c2ccc3c(c2)c2ccc(-c4cccc5c6cccc(-c7nc(-c8ccccc8)nc(-c8ccccc8)n7)c6n(-c6ccccc6)c45)cc2n3-c2ccccc2)cc1",
        "output": "349"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C[C@@H](NS(=O)(=O)Cc1ccc2ccccc2c1)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CC(C)C[C@@H](NS(=O)(=O)Cc1ccc2ccccc2c1)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)C1CCC(C(=O)CCl)CC1.CN(C)C=O.CS(=O)(=O)c1ccc2c(c1)[nH]c(=O)n2C1CCNCC1.O.O=C(O)C(F)(F)F>>CC(C)(C)C1CCC(C(=O)CN2CCC(n3c(=O)[nH]c4cc(S(C)(=O)=O)ccc43)CC2)CC1",
        "output": "414"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCOC(C)=O.CCOCCOCCN.CN(C)C=O.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OCCCCC(=O)O.ClCCCl.On1nnc2ccccc21>>CCOCCOCCNC(=O)CCCCOc1c(OC)cc(Cc2cnc(N)nc2N)cc1OC",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(C)c(B2OC(C)(C)C(C)(C)O2)cn1.Nc1c2c(nc3c(Br)c(F)ccc13)CN(C1CCC1)C2=O>>COc1cc(C)c(-c2c(F)ccc3c(N)c4c(nc23)CN(C2CCC2)C4=O)cn1",
        "output": "967"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1cccc(Oc2ccnc3[nH]c(=O)[nH]c23)c1.O=C(O)c1ccnc(N2CCSCC2)c1>>O=C(Nc1cccc(Oc2ccnc3[nH]c(=O)[nH]c23)c1)c1ccnc(N2CCSCC2)c1",
        "output": "50"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)Cl.CCOC(C)=O.CO.O=C(O)c1ccc2c(c1)NC(=O)C1(F)CCCC21.[BH4-].[Na+]>>O=C1Nc2cc(CO)ccc2C2CCCC12F",
        "output": "72"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCc1nc2cnc3ccccc3c2n1CC(C)(C)NC(=O)CCCCCNC(=O)OC(C)(C)C.ClCCl.O.O=C(O)C(F)(F)F.[NH4+].[OH-]>>CCOCc1nc2cnc3ccccc3c2n1CC(C)(C)NC(=O)CCCCCN",
        "output": "538"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCN1CCN(C(=O)c2ccc(-c3cc4c(Oc5ccc6[nH]c(C)cc6c5F)ncnc4[nH]3)cc2)CC1.CCOC(C)=O.O.O=S(=O)([O-])[O-].[Cl-].[H-].[NH4+].[Na+].[Na+]>>CCN1CCN(Cc2ccc(-c3cc4c(Oc5ccc6[nH]c(C)cc6c5F)ncnc4[nH]3)cc2)CC1",
        "output": "215"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)CCCBr.CN(C)C=O.N#Cc1cccc(O)c1.[H-].[Na+]>>CCOC(=O)CCCOc1cccc(C#N)c1",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCn1c(CCc2ccc(OCC(=O)OCC)cc2)nn(-c2ccc(C(F)(F)F)cc2)c1=O.CCO.II.O=S(=O)([O-])[O-].[Ag+2]>>CCCn1c(CCc2ccc(OCC(=O)OCC)c(I)c2)nn(-c2ccc(C(F)(F)F)cc2)c1=O",
        "output": "372"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Fc1cccc(COc2ccc(Nc3ncnc4cccc(OC5CCNCC5)c34)cc2Cl)c1.NC(=O)CCl>>NC(=O)CN1CCC(Oc2cccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c23)CC1",
        "output": "340"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CN2CCN1CC2.CC(c1ccc(O)cc1Cl)C(O)(c1ccc2c(c1)n(C)c(=O)n2C)C(F)(F)F.CCN(CC)CC.CN(C)C=O.COC(=O)c1ccc(Cl)nc1Cl.O>>COC(=O)c1ccc(Oc2ccc(C(C)C(O)(c3ccc4c(c3)n(C)c(=O)n4C)C(F)(F)F)c(Cl)c2)nc1Cl",
        "output": "516"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.COc1ccc(Cl)c(-c2ccccc2F)c1.ClCCl.O=C1CCC(=O)N1I.O=S(=O)(O)O>>COc1cc(-c2ccccc2F)c(Cl)cc1I",
        "output": "834"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.c1ccc2c(c1)CCc1ccccc1N2CC1CNCCO1.c1ccccc1>>CC(=O)N1CCOC(CN2c3ccccc3CCc3ccccc32)C1",
        "output": "125"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O.O=C([O-])O.OC1CCNC1.[Na+]>>CC(C)(C)OC(=O)N1CCC(O)C1",
        "output": "694"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=O.COc1cc2c(c(Cl)c1OC)CCNCC2c1ccc(SC)cc1.O=CO.[Na+].[OH-]>>COc1cc2c(c(Cl)c1OC)CCN(C)CC2c1ccc(SC)cc1",
        "output": "217"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(N2CCNCC2)cc1.O=C(NCC(F)(F)F)C1(CCCCBr)c2ccccc2-c2ccccc21>>COc1ccc(N2CCN(CCCCC3(C(=O)NCC(F)(F)F)c4ccccc4-c4ccccc43)CC2)cc1",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COc1ccc(-c2cnc(NC(=S)Cc3ccccc3)c(Cc3ccccc3)n2)cc1.ClCCl.O=C([O-])O.[Na+]>>Oc1ccc(-c2cnc(NC(=S)Cc3ccccc3)c(Cc3ccccc3)n2)cc1",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)NCCc1ccccc1N.COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2O[C@@H](C)C(=O)O)cc1>>COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2O[C@@H](C)C(=O)Nc2ccccc2CCNC(C)=O)cc1",
        "output": "365"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cc1ccc2c(c1)c1c(n2CC(C)(N=[N+]=[N-])c2cccnc2)CCN(C)C1.O.[Cl-].[NH4+].[Zn]>>Cc1ccc2c(c1)c1c(n2CC(C)(N)c2cccnc2)CCN(C)C1",
        "output": "89"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)/C=C/C1Cc2c(-c3ccc(C(=O)N4CC(F)C4)cc3)ccc(Cl)c2O1.Cl.O.[Li+].[OH-]>>O=C(O)/C=C/C1Cc2c(-c3ccc(C(=O)N4CC(F)C4)cc3)ccc(Cl)c2O1",
        "output": "122"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COc1ccc(CCl)cc1.O=[N+]([O-])c1cc[nH]n1.[H-].[Na+]>>COc1ccc(Cn2ccc([N+](=O)[O-])n2)cc1",
        "output": "842"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#CCO.CN(C(=O)OC(C)(C)C)c1ccc(I)cc1>>CN(C(=O)OC(C)(C)C)c1ccc(C#CCO)cc1",
        "output": "664"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCN1.ClCCl.O=C(Cl)Cc1cccs1>>O=C(Cc1cccs1)N1CCOCC1",
        "output": "125"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CNCc1ccccc1.COc1cc(OC)c2c(CNC(=O)OC(C)(C)C)ncc(C(=O)O)c2c1>>COc1cc(OC)c2c(CNC(=O)OC(C)(C)C)ncc(C(=O)N(C)Cc3ccccc3)c2c1",
        "output": "893"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)n1ncc2cc(N)ccc21.CC(C)(C)OC(=O)n1ncc2cc(N)ccc21.CC(C)O.COCCOc1cc2c(Cl)nc(-c3cccc(OCc4ccccc4)c3)nc2cc1OC>>COCCOc1cc2c(Nc3ccc4c(cnn4C(=O)OC(C)(C)C)c3)nc(-c3cccc(OCc4ccccc4)c3)nc2cc1OC",
        "output": "161"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCCCCCCCCC(O)C(=O)O.CO.O=S(Cl)Cl>>CCCCCCCCCCCCCC(O)C(=O)OC",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N1CCC(OCCc2ccccc2O)CC1.CC(C)O.CCI.CN(C)C=O.COCCOC.[H-].[Na+]>>CCOc1ccccc1CCOC1CCN(C(C)=O)CC1",
        "output": "198"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCC2=NCCCN2CC1.CC(C)(C)c1ccc(S)cc1.CN(C)C=O.O=[N+]([O-])c1ccc(Cl)c(Cl)c1>>CC(C)(C)c1ccc(Sc2ccc([N+](=O)[O-])cc2Cl)cc1",
        "output": "233"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)C1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)Oc2ccc([N+](=O)[O-])cc2)C1.N#CC1CCNCC1>>COC(=O)C1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)N2CCC(C#N)CC2)C1",
        "output": "770"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrBr.CC(=O)O.Nc1ccc(F)cn1>>Nc1ncc(F)cc1Br",
        "output": "292"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCCl.NCc1cc(F)cc(F)c1.O=C(O)c1nc(N2CCCCS2(=O)=O)cc(Br)c1O.On1nnc2ccccc21>>O=C(NCc1cc(F)cc(F)c1)c1nc(N2CCCCS2(=O)=O)cc(Br)c1O",
        "output": "905"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)C(C(=O)Cl)c1ccc(OC(F)F)cc1.ClCCl.N#CC(O)c1cccc(Oc2ccccc2)c1.c1ccncc1>>CC(C)C(C(=O)OC(C#N)c1cccc(Oc2ccccc2)c1)c1ccc(OC(F)F)cc1",
        "output": "126"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1CN(Cc2ccccc2)CC(N)CN1C.CN(C)C=O.O=C(O)c1n[nH]c2ccccc12>>CC1CN(Cc2ccccc2)CC(NC(=O)c2n[nH]c3ccccc23)CN1C",
        "output": "816"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C1Cc2c(ccc3cnn(C[C@H](C)N=[N+]=[N-])c23)O1.CO.Cl.[Pd]>>CCOC(=O)C1Cc2c(ccc3cnn(C[C@H](C)N)c23)O1",
        "output": "89"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrP(Br)Br.Cc1cc(CO)cc(C)c1Oc1ccc(O)c(C(C)C)c1.ClCCl>>Cc1cc(CBr)cc(C)c1Oc1ccc(O)c(C(C)C)c1",
        "output": "300"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1ccc(CCN(C)C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)c1ccc(CCNC)cc1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C[C@@H](CS(=O)(=O)N1CCCCC1)C(=O)OCc1ccccc1.[Pd]>>C[C@@H](CS(=O)(=O)N1CCCCC1)C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(C)=O.CCOC(=O)CCCBr.O=C([O-])[O-].Oc1ccc2c(c1)CCN(C1CCC1)CC2.[K+].[K+]>>CCOC(=O)CCCOc1ccc2c(c1)CCN(C1CCC1)CC2",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.C[O-].Cc1cc(Cl)nc2cc(Cl)ccc12.[H-].[Na+].[Na+]>>COc1cc(C)c2ccc(Cl)cc2n1",
        "output": "433"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=[N+]([O-])c1cccc(-n2cnc3ccccc32)c1.[Ni]>>Nc1cccc(-n2cnc3ccccc32)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CS(=O)(=O)Cl.ClCCl>>CS(=O)(=O)N1CCOCC1",
        "output": "584"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1O[C@@H]1CCNC1.O=C(O)C(F)F>>N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1O[C@@H]1CCN(C(=O)C(F)F)C1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(CC)CC.CN1CCCC1=O.Clc1ncncc1I.O=c1ccnc[nH]1>>CC(C)(C)OC(=O)N1CCN(c2ncncc2I)CC1",
        "output": "296"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CNC(=O)CC(C)NC1CCCC1.Clc1ncc(Br)c(Cl)n1.O=C([O-])[O-].[K+].[K+]>>CNC(=O)CC(C)N(c1nc(Cl)ncc1Br)C1CCCC1",
        "output": "296"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1c(N2CCNCC2)nc2cc(F)cc(F)c2c1Nc1cncc(N2CCOCC2)c1.O=C(O)c1cccnc1>>Cc1c(N2CCN(C(=O)c3cccnc3)CC2)nc2cc(F)cc(F)c2c1Nc1cncc(N2CCOCC2)c1",
        "output": "256"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)S(N)(=O)=O.CNS(N)(=O)=O.COc1ncccc1-c1cc(C(=O)O)ccc1Oc1cnc(OC(C)C)c(Cl)c1.O=C(O)c1cc(Cl)c(Oc2ccc(Cl)c(C(F)(F)F)c2)cc1F>>CNS(=O)(=O)NC(=O)c1ccc(Oc2cnc(OC(C)C)c(Cl)c2)c(-c2cccnc2OC)c1",
        "output": "886"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@H](COc1ccc(C#N)cc1)CN1CC2CN(C(=O)OCc3ccccc3)CC2C1.CCO.[Pd]>>CC(C)(C)OC(=O)N[C@H](COc1ccc(C#N)cc1)CN1CC2CNCC2C1",
        "output": "428"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.Cc1ccc(S(=O)(=O)O)cc1.Cn1cc(N)cn1.NC(=O)C1(c2ccccc2CCc2nc(Cl)ncc2Cl)CC1>>Cn1cc(Nc2ncc(Cl)c(CCc3ccccc3C3(C(N)=O)CC3)n2)cn1",
        "output": "992"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)n1nc(CCC=O)cc1-c1ccc(Cl)cc1.CCN(C(C)C)C(C)C.COc1ccc(N2CCNCC2)cc1.[Na+]>>COc1ccc(N2CCN(CCCc3cc(-c4ccc(Cl)cc4)n(C(C)(C)C)n3)CC2)cc1",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CNC.CS(=O)(=O)OCCCCNC(=O)OCc1ccccc1.O.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CN(C)CCCCNC(=O)OCc1ccccc1",
        "output": "496"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C[O-].Cc1ccccc1.Clc1cc(Cl)c2ccccc2n1.[Na+]>>COc1cc(Cl)c2ccccc2n1",
        "output": "433"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COc1c(CC(C)(C=O)c2ccc(NS(C)(=O)=O)cc2)cc(Br)cc1C(C)(C)C.[BH4-].[Na+]>>COc1c(CC(C)(CO)c2ccc(NS(C)(=O)=O)cc2)cc(Br)cc1C(C)(C)C",
        "output": "223"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Nc1cccnc1N.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCNc1cccnc1N",
        "output": "112"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)COc1ccc([N+](=O)[O-])cc1C(=O)NCc1ccc(Br)cc1F.ClCCl.O=C(O)C(F)(F)F>>O=C(O)COc1ccc([N+](=O)[O-])cc1C(=O)NCc1ccc(Br)cc1F",
        "output": "278"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C1COCCN1.CCN(CC)CC.O.O=C(Cl)CCCCBr>>O=C(CCCCBr)N1CCOCC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(F)(F)c1cc(N)n(-c2ccccc2)n1.ClCCl.O=C(Cl)Oc1ccccc1.O=C([O-])[O-].[K+].[K+]>>CC(F)(F)c1cc(NC(=O)Oc2ccccc2)n(-c2ccccc2)n1",
        "output": "700"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)N.CCN(CC)CC.CCOC(C)=O.ClCCl.O=S(=O)(Cl)c1ccc(Br)cc1>>CC(C)(C)NS(=O)(=O)c1ccc(Br)cc1",
        "output": "43"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(CC(c1ccc(Cl)cc1)c1ccc(Br)cc1)C(=O)OC(C)(C)C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[K+].[Pd].[Pd]>>CN(CC(c1ccc(Cl)cc1)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)C(=O)OC(C)(C)C",
        "output": "942"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCO.CCOC(C)=O.CN(CC(=O)n1ccc2ccc([N+](=O)[O-])cc21)C(=O)CN(C)C(=O)OC(C)(C)C.Cl[Sn]Cl.O>>CN(CC(=O)n1ccc2ccc(N)cc21)C(=O)CN(C)C(=O)OC(C)(C)C",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(C)=O.CCc1ccc(Br)cc1[N+](=O)[O-].Cl[Sn]Cl.O.O.O=C([O-])[O-].[Na+].[Na+]>>CCc1ccc(Br)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1sc2nc(-c3cnccn3)nc(Cl)c2c1Cl.NCc1ccc(Cl)c(Cl)c1>>Cc1sc2nc(-c3cnccn3)nc(NCc3ccc(Cl)c(Cl)c3)c2c1Cl",
        "output": "906"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)N1c2ccccc2C=CC1OCC.Cc1c(C)c(S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)OC(C)(C)C)C(=O)O)c(C)c2c1OC(C)(C)CC2.Cc1ccccc1.Nc1ccc(CO)cc1>>Cc1c(C)c(S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)OC(C)(C)C)C(=O)Nc2ccc(CO)cc2)c(C)c2c1OC(C)(C)CC2",
        "output": "365"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CI.CN(C)C=O.Cc1cc(I)c2c(C=O)c[nH]c2c1.[H-].[Na+]>>Cc1cc(I)c2c(C=O)cn(C)c2c1",
        "output": "191"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=CCC1(C)CCC=C(C)C1=O.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)=CCC1(C)CCC=C(C)C1O",
        "output": "288"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CN1C(=O)C(F)(F)CN(CCCc2ccccc2)c2nc(Cl)ncc21.COc1cc(C(=O)O)ccc1N.Cl.O>>COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(CCCc1ccccc1)CC(F)(F)C(=O)N2C",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cnc2n1CCNC2C.O=C(O)c1cc2ncc(Br)cn2n1>>Cc1cnc2n1CCN(C(=O)c1cc3ncc(Br)cn3n1)C2C",
        "output": "663"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1ccccc1.CCN(CC)CC.CCN(CC)CCOc1cccc(Br)c1.[Cu]I.[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCN(CC)CCOc1cccc(C#Cc2ccccc2)c1",
        "output": "659"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC(CNC(=O)C(F)(F)F)C1.CO.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(CN)C1",
        "output": "805"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CC(C)=O.CCCC[N+](CCCC)(CCCC)CCCC.O=C([O-])[O-].Oc1cc(Cl)cc(Br)c1.[I-].[K+].[K+]>>Clc1cc(Br)cc(OCc2ccccc2)c1",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NCCCc1ccc2ccccc2c1Cl.O=Cc1cccs1>>Clc1c(CCCNCc2cccs2)ccc2ccccc12",
        "output": "691"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCNc1ccc(C#N)cc1N=C1SC(=C2Sc3ccc(O)cc3N2C)C(=O)N1Cc1ccccc1.CN(C)C(=O)Cl.ClC(Cl)Cl>>CCNc1ccc(C#N)cc1N=C1SC(=C2Sc3ccc(OC(=O)N(C)C)cc3N2C)C(=O)N1Cc1ccccc1",
        "output": "425"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=C[C@H]1CNCC[C@H]1CCC(N)c1ccnc2ccc(OC)cc12.CCO.[Pd]>>CC[C@H]1CNCC[C@H]1CCC(N)c1ccnc2ccc(OC)cc12",
        "output": "116"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.CO.Cc1cc(NC(=O)OC(C)(C)C)nc(C)c1C#N.N.[H][H].[Ni]>>Cc1cc(NC(=O)OC(C)(C)C)nc(C)c1CN",
        "output": "560"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cnc(Nc2cnn(C)c2)nc1NC1CNCC12CCCC2.ClCCl.F[P-](F)(F)(F)(F)F.N#CCC(=O)O>>Cc1cnc(Nc2cnn(C)c2)nc1NC1CN(C(=O)CC#N)CC12CCCC2",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCc1cc(Cn2c(C)nc3ncccc32)cc(CCC)c1OC(C(=O)OC)c1ccc2c(c1)OCO2.CO.ClCCl.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>CCCc1cc(Cn2c(C)nc3ncccc32)cc(CCC)c1OC(C(=O)O)c1ccc2c(c1)OCO2",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CO.COC(=O)C(Cl)Cl.CS(=O)(=O)c1ccc([C@@H](O)[C@H](N)CF)cc1>>CS(=O)(=O)c1ccc([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)cc1",
        "output": "392"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccc(I)cc1.CC(C)(C)OC(=O)C(C)(C)Oc1ccc(CCC(O)c2ccc(-c3ccc(C(F)(F)F)cc3)s2)c(Cl)c1Cl.[H-].[Na+]>>CC(C)(C)OC(=O)C(C)(C)Oc1ccc(CCC(OCc2ccc(I)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)s2)c(Cl)c1Cl",
        "output": "464"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N(C)c1cc2c(cc1[N+](=O)[O-])N(C)C(=O)C2(C)C.Cl>>CNc1cc2c(cc1[N+](=O)[O-])N(C)C(=O)C2(C)C",
        "output": "504"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)Cc1ccc(C#CCCO)cc1.[H][H].[Pd]>>COC(=O)Cc1ccc(CCCCO)cc1",
        "output": "717"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1cccc2ccc(O)cc12.CCI.CN(C)C=O.O.O=C([O-])[O-].[Cs+].[Cs+]>>CCOc1ccc2cccc(NC(=O)OC(C)(C)C)c2c1",
        "output": "198"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CC(C)S(=O)(=O)NC1COCCC12OCCO2.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccc(S(=O)(=O)[O-])cc1.O.O=S(=O)(O)O.c1cc[nH+]cc1>>CC(C)S(=O)(=O)NC1COCCC1=O",
        "output": "251"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NC[C@@H]1CNC[C@H]1C(F)(F)F.Cl.ClCCl.O=C(O)C(F)(F)F>>NC[C@@H]1CNC[C@H]1C(F)(F)F",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C)C=O.CNCCO.ClCCl.O.O=C(Cl)C(=O)Cl.O=C(O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1.O=C([O-])O.[Na+]>>CN(CCO)C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cl.O=C1CC2c3ccccc3CCN2C2CCCCC12>>OC1CC2c3ccccc3CCN2C2CCCCC12",
        "output": "91"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)O)n2c1.Cl.F[P-](F)(F)(F)(F)F.NC1CC1N.O=C(O)C(F)(F)F>>Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)NC3CC3N)n2c1",
        "output": "697"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)Sc1cccnc1CN.CO.Cl>>CC(C)Sc1cccnc1CNC(=O)OC(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.CC(=O)[O-].COc1ccc(Br)cc1C=O.Cl.NO.[Na+].[Na+].[OH-]>>COc1ccc(Br)cc1C#N",
        "output": "453"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.Cc1c(NC(=O)CC(C)(C)C)c(C)c2c(c1-c1cccc(N)n1)OCC2c1ccc(C(C)C)cc1.O=C([O-])O.[Na+]>>CC(=O)Nc1cccc(-c2c(C)c(NC(=O)CC(C)(C)C)c(C)c3c2OCC3c2ccc(C(C)C)cc2)n1",
        "output": "332"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cc1nc(N2CCC(C(=O)O)CC2)c(C#N)cc1C(=O)OC(C)C.ClCCl.F[B-](F)(F)F.NS(=O)(=O)Cc1ccccc1F.O=C([O-])O.[Na+]>>Cc1nc(N2CCC(C(=O)NS(=O)(=O)Cc3ccccc3F)CC2)c(C#N)cc1C(=O)OC(C)C",
        "output": "644"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCOC(=O)Cl.COC(=O)c1ccc(Cn2c(C)c(C)c3cc(C)c(N)cc32)c(OC)c1>>CCCCOC(=O)Nc1cc2c(cc1C)c(C)c(C)n2Cc1ccc(C(=O)OC)cc1OC",
        "output": "102"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)COc1cccc(CN(Cc2ccc(-c3nccs3)cc2)S(=O)(=O)c2ccc(Cl)cc2)c1>>O=C(O)COc1cccc(CN(Cc2ccc(-c3nccs3)cc2)S(=O)(=O)c2ccc(Cl)cc2)c1",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.CO.COc1ccc(-c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)cc1OC.ClCCl.[Na+].[OH-]>>O=[N+]([O-])c1ccc(Oc2ccnc3cc(-c4ccc(O)c(O)c4)sc23)c(F)c1",
        "output": "19"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1ccccc1.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc2[nH]ncc2c1.[K+].[K+]>>O=[N+]([O-])c1ccc2c(cnn2Cc2ccccc2)c1",
        "output": "635"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-].OC1CC2CC1CN(Cc1ccccc1)C2>>O=C1CC2CC1CN(Cc1ccccc1)C2",
        "output": "87"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.Cc1ccccc1.N#Cc1cc2c(Oc3ccc(N)c(F)c3)ccnc2cc1OCc1ccccc1.O=C=Nc1ccccc1>>N#Cc1cc2c(Oc3ccc(NC(=O)Nc4ccccc4)c(F)c3)ccnc2cc1OCc1ccccc1",
        "output": "912"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)C(=O)Cl.Cn1nc(-c2ccc3c(c2)c2cc(-c4ccc(Cl)cc4Cl)c(=O)n(C)c2n3C)cc1CO>>Cn1nc(-c2ccc3c(c2)c2cc(-c4ccc(Cl)cc4Cl)c(=O)n(C)c2n3C)cc1COC(=O)C(C)(C)C",
        "output": "126"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNc1ccc(C(=O)NCC(=O)N(C)C)cc1[N+](=O)[O-].CO.[Pd]>>CNc1ccc(C(=O)NCC(=O)N(C)C)cc1N",
        "output": "489"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(N2CCNCC2)c2ncccc2c1.Clc1ccc2occ(CCI)c2c1>>Cc1cc(N2CCN(CCc3coc4ccc(Cl)cc34)CC2)c2ncccc2c1",
        "output": "184"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COCCl.O=[N+]([O-])c1cc(Br)ccc1O>>COCOc1ccc(Br)cc1[N+](=O)[O-]",
        "output": "375"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(OC(F)(F)C(F)(F)Br)cc1>>O=C(Cl)c1ccc(OC(F)(F)C(F)(F)Br)cc1",
        "output": "448"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CO.Cc1cc(C(=O)N2CCN(C(=O)OC(C)(C)C)Cc3ccccc32)ccc1CCCC(=O)N1CCN(CCC(C)(C)C)CC1.Cl>>Cc1cc(C(=O)N2CCNCc3ccccc32)ccc1CCCC(=O)N1CCN(CCC(C)(C)C)CC1",
        "output": "887"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=C(C)c1cccc(C)c1-n1cncc1C(=O)OCC.Cl.[Na+].[OH-]>>C=C(C)c1cccc(C)c1-n1cncc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCC.O.O=[N+]([O-])c1ccc(CN2CCN(c3ccc(F)cc3)CC2)cc1.[Cl-].[Cl-].[Cl-].[Ti+3]>>Nc1ccc(CN2CCN(c3ccc(F)cc3)CC2)cc1",
        "output": "507"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCBr.CCOC(=O)[C@@H](CSCc1cccc(O)c1)NC(=O)Cn1cc(COc2ccc3nc(S(=O)(=O)NC(c4ccccc4)(c4ccc(OC)cc4)c4ccc(OC)cc4)sc3c2)nn1.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>C#CCOc1cccc(CSC[C@@H](NC(=O)Cn2cc(COc3ccc4nc(S(=O)(=O)NC(c5ccccc5)(c5ccc(OC)cc5)c5ccc(OC)cc5)sc4c3)nn2)C(=O)OCC)c1",
        "output": "154"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.CCO.CS(=O)(=O)OCCc1cccc(N2C(=O)N(c3ccc(Cl)cc3Cl)Cc3cnc(Nc4ccccc4)nc32)c1>>O=C1N(c2ccc(Cl)cc2Cl)Cc2cnc(Nc3ccccc3)nc2N1c1cccc(CCN2CCOCC2)c1",
        "output": "496"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.CCN(C(C)C)C(C)C.ClCCl.NCC1CCOCC1>>CC(=O)NCC1CCOCC1",
        "output": "339"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NCC(=O)NC(CC#N)c1ccc(-c2ccccc2)cc1.ClCCl.O=C(O)C(F)(F)F>>N#CCC(NC(=O)CN)c1ccc(-c2ccccc2)cc1",
        "output": "431"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O=C1CCC(c2cc(F)ccc2C(F)(F)F)(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1.[BH4-].[Na+]>>O=S(=O)(c1ccc(C(F)(F)F)cc1)C1(c2cc(F)ccc2C(F)(F)F)CCC(O)CC1",
        "output": "91"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCS.O=C1CC[C@H](/C=C/CC2CCCCC2)[C@H]1CCCCCCCBr.[H-].[Na+]>>CCSCCCCCCC[C@H]1C(=O)CC[C@@H]1/C=C/CC1CCCCC1",
        "output": "185"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CN=C=O.O=C(N1CCOCC1)N1CC(CO)CC(c2ccc(C(F)(F)F)cc2)C1>>CC(C)CNC(=O)OCC1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)N2CCOCC2)C1",
        "output": "235"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CN(C)C=O.CS(=O)(=O)OC[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1.O.[N-]=[N+]=[N-].[Na+]>>[N-]=[N+]=NC[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1",
        "output": "322"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CCCC(CO)CO.Oc1ccc(Cl)cc1>>C=CCCC(CO)COc1ccc(Cl)cc1",
        "output": "478"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCSc1ccc(C2=NCC(O)C(c3ccccc3)O2)cc1.ClCCCl.O=C=Nc1ccccc1>>CCSc1ccc(C2=NCC(OC(=O)Nc3ccccc3)C(c3ccccc3)O2)cc1",
        "output": "34"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CN(C)c1sc2cc(OCc3ccccc3)ccc2c1C(=O)c1ccc(CN2CCCC2)c([N+](=O)[O-])c1.CO.O.[BH4-].[Na+].[Na+].[OH-]>>CN(C)c1sc2cc(OCc3ccccc3)ccc2c1C(=O)c1ccc(CN2CCCC2)c(N)c1",
        "output": "588"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N(C)C.CCC1(C(=O)O)CCc2c(sc3ncnc(Nc4cc5cn[nH]c5cc4OC)c23)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CNC.F[P-](F)(F)(F)(F)F>>CCC1(C(=O)N(C)C)CCc2c(sc3ncnc(Nc4cc5cn[nH]c5cc4OC)c23)C1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cl.ClCCl.O=C(N[C@H]1c2cc(N3CCNCC3)ccc2OC[C@@H]1O)c1ccc(F)cc1.O=C([O-])O.O=C1COC1.[Na+].[Na+]>>O=C(N[C@H]1c2cc(N3CCN(C4COC4)CC3)ccc2OC[C@@H]1O)c1ccc(F)cc1",
        "output": "983"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1CCNCC1.CC(C)(C)P(c1ccccc1-c1ccccc1)C(C)(C)C.CC(C)(C)[O-].CCCCC.CCOC(C)=O.CCOCC.COc1c(F)cc(Br)cc1F.Cc1ccccc1.[Na+].[Pd+2]>>COc1c(F)cc(N2CCN(C(=O)OC(C)(C)C)CC2)cc1F",
        "output": "294"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC[N+](CC)(CC)Cc1ccccc1.CI.ClCCl.N#CCc1c[nH]c2ccc([N+](=O)[O-])cc12.O.[Cl-].[Na+].[OH-]>>Cn1cc(CC#N)c2cc([N+](=O)[O-])ccc21",
        "output": "191"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc(OCc2ccccc2)c(C(CCNC2CCC2)c2ccccc2)c1.C=O.CO.CO.Cl.[BH3-]C#N.[Na+]>>CN(CCC(c1ccccc1)c1cc(Br)ccc1OCc1ccccc1)C1CCC1",
        "output": "217"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)OCC(CN(c2ccccc2)S(=O)(=O)c2ccc(Cl)nc2)O1.NN.O>>CC1(C)OCC(CN(c2ccccc2)S(=O)(=O)c2ccc(NN)nc2)O1",
        "output": "417"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.COc1c([N+](=O)[O-])ccc(CC#N)c1C.[Pd]>>COc1c(N)ccc(CC#N)c1C",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CN2CCC(CC2)N1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.Cl.F[B-](F)(F)F.O.O=C(O)c1ccc(Cl)cc1.On1nnc2ccccc21.[Na+].[OH-]>>O=C(c1ccc(Cl)cc1)N1CCN2CCC1CC2",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "O=C(O)C(F)(F)F.O=C(O)Cn1cnc2c(=O)[nH]c(NC(=O)OCc3ccccc3)nc21.O=C1CNCCN1S(=O)(=O)c1nc2ccccc2s1>>O=C(Nc1nc2c(ncn2CC(=O)N2CCN(S(=O)(=O)c3nc4ccccc4s3)C(=O)C2)c(=O)[nH]1)OCc1ccccc1",
        "output": "297"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO/C=C/c1nc(Br)[nH]c1C(=O)OC.Cl.O.[Li+].[OH-]>>CO/C=C/c1nc(Br)[nH]c1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)C(=O)N(C2C3CC4CC(C3)CC2C4)N1C1C=CCCC1.CCO.[C].[Pd]>>CC1(C)C(=O)N(C2C3CC4CC(C3)CC2C4)N1C1CCCCC1",
        "output": "143"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)CN1CCc2c(C(F)(F)F)nn(CC(=O)Nc3cc(Cl)ccc3OC)c2C1.CO.O.[Li+].[OH-]>>COc1ccc(Cl)cc1NC(=O)Cn1nc(C(F)(F)F)c2c1CN(CC(=O)O)CC2",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNCCCN(C)C(=O)c1ccc(NCCC(=O)N(C)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)cc1.O=C(O)CO[C@H]1Cc2ccccc2C12CCN(CC[C@@]1(c3ccc(F)cc3)CN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CO1)CC2>>CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)CCNc1ccc(C(=O)N(C)CCCN(C)C(=O)CO[C@H]2Cc3ccccc3C23CCN(CC[C@@]2(c4ccc(F)cc4)CN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CO2)CC3)cc1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(=O)c1csc(N)n1.O.O=C(Cl)c1ccccc1OC(F)(F)F>>CCOC(=O)c1csc(NC(=O)c2ccccc2OC(F)(F)F)n1",
        "output": "673"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.Cc1cccc(C)n1.ClCCl.O.O=C(NCC1CC(c2ccc(NCCO)cc2)=NO1)c1ccc(Cl)s1>>CC(C)(C)[Si](C)(C)OCCNc1ccc(C2=NOC(CNC(=O)c3ccc(Cl)s3)C2)cc1",
        "output": "839"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)NC(C)CCc1ccc(O)cc1.CN1CCCC1=O.Clc1ccc(OC2CCCC2)cn1.[H-].[Na+]>>CC(=O)NC(C)CCc1ccc(Oc2ccc(OC3CCCC3)cn2)cc1",
        "output": "516"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.ClCCl.O=C(O)c1cc(F)cc(F)c1O.O=S(Cl)Cl>>O=C(Cl)c1cc(F)cc(F)c1O",
        "output": "3"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(CC(C)=O)cc1.NCC(O)c1cccc(F)c1.[BH4-].[Na+]>>COc1ccc(CC(C)NCC(O)c2cccc(F)c2)cc1",
        "output": "236"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "NC[C@@H]1[C@H]2C[C@H]2CN1C(=O)c1nc(N)sc1-c1cccc(F)c1.O=C(O)c1ccc2ccccc2n1>>Nc1nc(C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2ccc3ccccc3n2)c(-c2cccc(F)c2)s1",
        "output": "137"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cnn(CCCl)c4)cc23)CC1.CNCCO.[I-].[Na+]>>CCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4cnn(CCN(C)CCO)c4)cc23)CC1",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)COCc1ccc(CN(C)C)s1.N>>CN(C)Cc1ccc(COCC(N)=O)s1",
        "output": "163"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(=O)N1CCC(COc2cccc([C@H](O)CCNC(=O)OC(C)(C)C)c2)CC1.Cl.ClCCl>>CC(=O)N1CCC(COc2cccc([C@H](O)CCN)c2)CC1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.O=C(O)CCc1cnoc1-c1ccc(F)cc1.O=S(=O)(O)O>>COC(=O)CCc1cnoc1-c1ccc(F)cc1",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CNC.Cc1cc(C)n(-c2ccc(C(=O)O)cc2O)n1.Cl.O.On1nnc2ccccc21>>Cc1cc(C)n(-c2ccc(C(=O)N(C)C)cc2O)n1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.C1CSCCN1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].O=[N+]([O-])c1cc(Br)cc(C(F)(F)F)c1.[Cs+].[Cs+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>O=[N+]([O-])c1cc(N2CCSCC2)cc(C(F)(F)F)c1",
        "output": "294"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CC(=O)c1cc2ccc(Br)cc2oc1=O.ClC(Cl)Cl>>O=C(CBr)c1cc2ccc(Br)cc2oc1=O",
        "output": "173"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COCCn1c(-c2ccc(C(C)C)cc2)nc2c(Br)c(C=O)cc(OC)c21.COc1cccc([Mg]Br)c1>>COCCn1c(-c2ccc(C(C)C)cc2)nc2c(Br)c(C(O)c3cccc(OC)c3)cc(OC)c21",
        "output": "309"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)OC(=O)c1cc(C#N)c(N2CCC(C(=O)O)CC2)nc1CN1CCCC1=O.NS(=O)(=O)Cc1ccc(F)cc1>>CC(C)OC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccc(F)cc3)CC2)nc1CN1CCCC1=O",
        "output": "644"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)[C@@H](N)CC(N)=O.Cl.O=C(O)CNC(=O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(Cl)cc2Cl)cc1>>COC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(Cl)cc2Cl)cc1",
        "output": "129"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.Cc1cc(SC#N)c(C(C)(C)C)cc1O.O=C([O-])O.[Na+].c1c[nH]cn1>>Cc1cc(SC#N)c(C(C)(C)C)cc1O[Si](C)(C)C(C)(C)C",
        "output": "746"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "B.C1CCOC1.C1CCOC1.CCOC(C)=O.NCCO.O=C(O)Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>OCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1",
        "output": "231"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.CC(C)=O.COc1ccc(Oc2ccc(C(=O)CCC(=O)NCCc3cccnc3)cc2)cc1.ClCCl.O=C=O>>O=C(CCC(=O)c1ccc(Oc2ccc(O)cc2)cc1)NCCc1cccnc1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C(C#N)=NOC(N1CCOCC1)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1ccc(-c2cc(Br)cnc2N)cc1.O.O=C(O)c1cn(CCF)cc(-c2ccc(F)cc2)c1=O>>Nc1ncc(Br)cc1-c1ccc(NC(=O)c2cn(CCF)cc(-c3ccc(F)cc3)c2=O)cc1",
        "output": "739"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCc1ccc(Oc2ccc(S(=O)(=O)NCCCn3ccnc3)cc2F)c(OCc2ccccc2)c1>>CCc1ccc(Oc2ccc(S(=O)(=O)NCCCn3ccnc3)cc2F)c(O)c1",
        "output": "23"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CC1(NC(=O)c2ccc(N3CC(F)(F)C3)c(OCC3CC3)n2)CS(=O)(=O)C1.[Li+].[OH-]>>O=C(O)CC1(NC(=O)c2ccc(N3CC(F)(F)C3)c(OCC3CC3)n2)CS(=O)(=O)C1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CN(C)C=O.ClCCCl.O.O=C(O)c1cc(-c2ccc3[nH]ncc3c2)on1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCC(NC(=O)c2cc(-c3ccc4[nH]ncc4c3)on2)CC1",
        "output": "696"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N(C)C.CCCCOC(=O)c1nc(N2CC[C@H](N)[C@H](OC)C2)oc1CCC.CCN=C=NCCCN(C)C.CCc1[nH]c(C(=O)O)nc1Cl.Cl.ClCCl.On1nnc2ccccc21>>CCCCOC(=O)c1nc(N2CC[C@H](NC(=O)c3nc(Cl)c(CC)[nH]3)[C@H](OC)C2)oc1CCC",
        "output": "951"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1cnc2[nH]ccc2c1.CN(C)C=O.O.O=S(=O)(Cl)c1ccccc1.[H-].[Na+]>>O=S(=O)(c1ccccc1)n1ccc2cc(Br)cnc21",
        "output": "354"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(C)=O.N#Cc1cc(-c2nc3cncnc3s2)ccc1Cl.O.Oc1ccc(F)cc1.[H-].[Na+]>>N#Cc1cc(-c2nc3cncnc3s2)ccc1Oc1ccc(F)cc1",
        "output": "299"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CNOC.Cl.Cl.Nc1ncnc(Nc2ccc(CC(=O)O)cc2)c1-c1ccc(Oc2ccccc2)cc1.On1nnc2ccccc21>>CON(C)C(=O)Cc1ccc(Nc2ncnc(N)c2-c2ccc(Oc3ccccc3)cc2)cc1",
        "output": "54"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.NC(=O)c1cccc(Oc2ccccc2)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCc1cccc(Oc2ccccc2)c1",
        "output": "215"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)c1c(C)c[nH]c1CC(=O)NCCN1CCCCC1.Cl.O.[Na+].[OH-]>>CCOC(=O)c1c(C)c[nH]c1CCNCCN1CCCCC1",
        "output": "112"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.CO.COc1ccc(I)cc1CC(C)C.ClCCl.ClCCl.O>>CC(C)Cc1cc(I)ccc1O",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.Cl.O=C(O)c1ccnc(Cl)c1.[BH4-].[Na+]>>OCc1ccnc(Cl)c1",
        "output": "72"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.Cc1cc(SC(=O)N(C)C)c(C(C)(C)C)cc1C=O.Cc1ccccc1.Cl.O.[BH4-].[Li+]>>Cc1cc(SC(=O)N(C)C)c(C(C)(C)C)cc1CO",
        "output": "356"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.COCCBr.CS(=O)(=O)Oc1cccc(C2CCNCC2)c1F.O=C([O-])[O-].O=C(c1cccc(C2CCNCC2)c1F)C(F)(F)F.[K+].[K+]>>COCCN1CCC(c2cccc(C(=O)C(F)(F)F)c2F)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Brc1ccc(Br)cc1.C1COCCO1.CC(=O)[O-].CC(=O)[O-].O=C([O-])[O-].O=S1(=O)CCNCC1.[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>O=S1(=O)CCN(c2ccc(Br)cc2)CC1",
        "output": "294"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)CC(=O)O.O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1CO.c1ccncc1>>CN(C)CC(=O)OCN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.CON.CS(=O)(=O)c1ccc(C(CC2CCC(=O)CC2)C(=O)Nc2cnc(Br)cn2)cc1Cl.Cl.c1ccncc1>>CON=C1CCC(CC(C(=O)Nc2cnc(Br)cn2)c2ccc(S(C)(=O)=O)c(Cl)c2)CC1",
        "output": "86"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCOC(C)=O.CN.O.O=C(Nc1c(Br)cc(C(F)(C(F)(F)F)C(F)(F)F)cc1C(F)(F)F)c1cccc(Cl)n1.O=S(=O)([O-])[O-].[Cu+2]>>CNc1cccc(C(=O)Nc2c(Br)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2C(F)(F)F)n1",
        "output": "70"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=Cc1ccccn1.[Cl-].[NH3+]CCOc1ccc2ccccc2c1F>>Fc1c(OCCNCc2ccccn2)ccc2ccccc12",
        "output": "775"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)C=O.CNCc1cc2ccccc2n1C.ClCCCl.O.O=C(O)/C=C/c1cnc2c(c1)CCCN2.On1nnc2ccccc21>>CN(Cc1cc2ccccc2n1C)C(=O)/C=C/c1cnc2c(c1)CCCN2",
        "output": "811"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.O=C(Nc1cccnc1O)OCc1ccccc1.O=C1CCC(=O)N1I>>O=C(Nc1cc(I)cnc1O)OCc1ccccc1",
        "output": "783"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CO)C(=O)O.CCI.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)[C@H](CO)NC(=O)OC(C)(C)C",
        "output": "196"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccc2c(c1)CCCN2.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1>>CC(=O)c1ccc2c(c1)CCCN2C(=O)OC(C)(C)C",
        "output": "827"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COCCn1cc(C(=O)O)c2c(F)ccc(Cl)c21.Cl.O=C(NCc1ccc(F)c(C2CCNCC2)c1)C(F)(F)F>>COCCn1cc(C(=O)N2CCC(c3cc(CNC(=O)C(F)(F)F)ccc3F)CC2)c2c(F)ccc(Cl)c21",
        "output": "256"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccc(Br)cc1.CC#N.O=C([O-])[O-].[K+].[K+].c1ccc(C2CNCCN2)cc1>>Brc1ccc(CN2CCNC(c3ccccc3)C2)cc1",
        "output": "248"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=CBr)c1ccccc1F.CN(C)C=O.CN1CCc2[nH]c3ccc(Cl)cc3c2C1.O=C(O)[C@@H]1CCCN1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>C/C(=C\\n1c2c(c3cc(Cl)ccc31)CN(C)CC2)c1ccccc1F",
        "output": "987"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1sc2ccccc2c1OC(C)C.O.O.[Li+].[OH-]>>CC(C)Oc1c(C(=O)O)sc2ccccc12",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CN(C)C=O.Cc1c(NC(=O)CC(C)(C)C)cc2c(c1C)OC(C)(C)C2c1ccc(Br)cc1.O.[Li]CCCC>>Cc1c(NC(=O)CC(C)(C)C)cc2c(c1C)OC(C)(C)C2c1ccc(C=O)cc1",
        "output": "638"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=S(=O)(c1ccccc1)n1cc(-c2ccc3[nH]cnc3c2)c2ccc(F)cc21.O=S(=O)(c1ccccc1)n1cc(I)c2ccc(F)cc21>>Fc1ccc2c(-c3ccc4[nH]cnc4c3)c[nH]c2c1",
        "output": "771"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1nc(-c2cccc([N+](=O)[O-])c2)cs1.Cl.Cl[Sn]Cl.O.O.O.[K+].[OH-]>>CCOC(=O)c1nc(-c2cccc(N)c2)cs1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCl.O=C(OO)c1cccc(Cl)c1.OCc1ccc(Br)cn1>>[O-][n+]1cc(Br)ccc1CO",
        "output": "262"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1ccc(C#N)cc1.CO.O.[Na+].[OH-]>>N#Cc1ccc(C(=O)O)cc1",
        "output": "5"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C(=O)OCC)c1csc(N)n1.CCOC(C)=O.CN(C)C=O.O.O=C(Cl)CCl>>CCOC(=O)C(C(=O)OCC)c1csc(NC(=O)CCl)n1",
        "output": "553"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C)Cc1ccc(C(Cc2cc(Cl)c3cccnc3c2OCc2ccccc2)N=[N+]=[N-])o1.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN(C)Cc1ccc(C(N)Cc2cc(Cl)c3cccnc3c2OCc2ccccc2)o1",
        "output": "89"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(Br)cn1.OB(O)c1ccc(Br)cc1>>COc1ccc(-c2ccc(Br)cc2)cn1",
        "output": "833"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.CCCCCC.CCOC(C)=O.O=C(O)C1=Cc2ccccc2Oc2ccccc21>>O=C(C1=Cc2ccccc2Oc2ccccc21)N1CCOCC1",
        "output": "517"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)C1CCCCC1=O.O.[Na+].[OH-]>>O=C(O)C1CCCCC1=O",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(=O)CCN1CCNCC1=O.CN(C)C=O.COc1cccc([C@H]2O[C@H](CCC(=O)O)c3cccn3-c3ccc(Cl)cc32)c1OC.Cl.Cl.ClCCl.O.O.On1nnc2ccccc21>>CCOC(=O)CCN1CCN(C(=O)CC[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3-n3cccc32)CC1=O",
        "output": "297"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc2occc2c1.C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.[Li]CCCC>>OB(O)c1ccc2occc2c1",
        "output": "832"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COc1ccc(C(C)C(=O)O)cc1OC.ClCCl.O=C(Cl)C(=O)Cl>>COc1ccc(C(C)C(=O)Cl)cc1OC",
        "output": "56"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.Cc1nc2c3c(nn2c(C)c1Cl)CN(C(=O)c1ccccc1OCCN(C)CCO[Si](C)(C)C(C)(C)C)C3.[F-]>>Cc1nc2c3c(nn2c(C)c1Cl)CN(C(=O)c1ccccc1OCCN(C)CCO)C3",
        "output": "708"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.CO.COc1ccc(Oc2ccc(CN3CCC(N4C(=O)NC[C@H]4c4ccccc4)CC3)c(C)n2)cc1.ClCCl>>Cc1nc(Oc2ccc(O)cc2)ccc1CN1CCC(N2C(=O)NC[C@H]2c2ccccc2)CC1",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(CC)CC.Cn1ccc2ncnc(Oc3ccc(N)c4cccnc34)c21.O=C=Nc1cccc(C(F)(F)F)c1>>Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)c4cccnc34)c21",
        "output": "912"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCC1CC1.Brc1ccc2[nH]ncc2c1.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>Brc1ccc2c(cnn2CC2CC2)c1",
        "output": "577"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCc2ccc(-c3ccc(-c4cncc(N)c4)s3)cc2C1=O.CO.ClCCl.O=S(=O)(Cl)c1ccc(F)cc1F>>CN1CCc2ccc(-c3ccc(-c4cncc(NS(=O)(=O)c5ccc(F)cc5F)c4)s3)cc2C1=O",
        "output": "554"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCCCCCCc1ccc2c(c1)CCC(C(CO)(CO)NC(C)=O)C2.CCOC(C)=O.CO.O.[Li+].[OH-]>>CCCCCCCCc1ccc2c(c1)CCC(C(N)(CO)CO)C2",
        "output": "412"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CCCCCCCCS(=O)(=O)Cl.Cl.Nc1ccc(CCc2cc(O)ccc2O)cc1.c1ccncc1>>CCCCCCCCS(=O)(=O)Nc1ccc(CCc2cc(O)ccc2O)cc1",
        "output": "194"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1cccc(C=O)c1O.Cc1ccccc1.ClCCCN1CCOCC1.[H-].[Na+]>>COc1cccc(C=O)c1OCCCN1CCOCC1",
        "output": "74"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.COCCn1ncc([N+](=O)[O-])c1Cl.O.[Fe]>>COCCn1ncc(N)c1Cl",
        "output": "628"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CNC(=O)CN1CCc2cc(N)c(OC)cc2CC1.Cc1cc(Nc2nc(Cl)ncc2Cl)ccc1N1CCN(C)CC1>>CNC(=O)CN1CCc2cc(Nc3ncc(Cl)c(Nc4ccc(N5CCN(C)CC5)c(C)c4)n3)c(OC)cc2CC1",
        "output": "808"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "FC(F)(F)c1cc(N=C=S)ccc1Cl.Nc1ccc(Sc2ccnc3ccccc23)cc1>>FC(F)(F)c1cc(NC(=S)Nc2ccc(Sc3ccnc4ccccc34)cc2)ccc1Cl",
        "output": "474"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2cc(OC)ccc23)cc1.Cc1cccc(NC(=O)Nc2ccc(N)cc2)c1.Cl>>COc1ccc2c(c1)nc(Nc1ccc(NC(=O)Nc3cccc(C)c3)cc1)c1n[nH]cc12",
        "output": "998"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.COc1ccc(C(=CC(=O)N2CCOCC2)c2ccccc2)cc1[N+](=O)[O-].Cc1ccccc1.O.O=S([O-])S(=O)[O-].[Na+].[Na+]>>COc1ccc(C(=CC(=O)N2CCOCC2)c2ccccc2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClCCl.O=C1c2cc3c(n2CCN1c1nccc(Cl)c1CO)CCCC3>>CC(=O)OCc1c(Cl)ccnc1N1CCn2c(cc3c2CCCC3)C1=O",
        "output": "126"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=[N+]=[N-].COC(=O)/C=C/[C@H]1[C@@H](C(=O)O)C1(C)C.ClC(Cl)Cl.ClCCl>>COC(=O)/C=C/[C@H]1[C@@H](C(=O)OC)C1(C)C",
        "output": "60"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1ccc(Oc2ccnc3cc(-c4cccc(OCCN5CCOCC5)c4)sc23)c(F)c1.O=[N+]([O-])c1ccc(Oc2ccnc3cc(-c4ccc(OCCN5CCOCC5)cc4)sc23)cc1>>Nc1ccc(Oc2ccnc3cc(-c4ccc(OCCN5CCOCC5)cc4)sc23)cc1",
        "output": "335"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)C(=O)NC1CCc2c(c3cc(C#N)ccc3n2Cc2cccc(F)c2)C1.CS(C)=O.O.O=C([O-])[O-].OO.[K+].[K+]>>CC(C)C(=O)NC1CCc2c(c3cc(C(N)=O)ccc3n2Cc2cccc(F)c2)C1",
        "output": "180"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.Cc1ccnc(C)c1C(=O)O.NCc1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)cc1.O=S(Cl)Cl>>Cc1ccnc(C)c1C(=O)NCc1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)cc1",
        "output": "790"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)O.CC=C(C)C.COc1ccc(C=O)cc1-c1nn(C)c2nc(N)ncc12.O.O=P([O-])(O)O.[Na+].[Na+].[O-][Cl+][O-]>>COc1ccc(C(=O)O)cc1-c1nn(C)c2nc(N)ncc12",
        "output": "384"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC.COc1cc(Br)ccc1C(=O)c1ccc(F)cc1.Cl.c1ccncc1>>O=C(c1ccc(F)cc1)c1ccc(Br)cc1O",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)c1ccncc1.Cc1ccc(C(=O)Nc2ccc(C(=O)O)cc2)c(N2CCC(C)CC2)c1.Nc1ccccn1.O.O=C([O-])[O-].On1nnc2ccccc21.[K+].[K+]>>Cc1ccc(C(=O)Nc2ccc(C(=O)Nc3ccccn3)cc2)c(N2CCC(C)CC2)c1",
        "output": "744"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CO.O=C1CCC(Cc2ccccc2)CC1.[BH3-]C#N.[NH4+].[Na+]>>NC1CCC(Cc2ccccc2)CC1",
        "output": "63"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cccnc1N.O=C(O)c1cccc(S(=O)(=O)N2CCCCC2)c1>>Cc1cccnc1NC(=O)c1cccc(S(=O)(=O)N2CCCCC2)c1",
        "output": "744"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCI.CCOC(C)=O.COC(=O)c1c[nH]c2ccccc12.O.[H-].[Na+]>>CCn1cc(C(=O)OC)c2ccccc21",
        "output": "302"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(C(=O)N2CCC(N)CC2)cc1.CCN(C(C)C)C(C)C.CCO.CCOC(C)=O.CN(C)C=O.O=S(=O)(c1ccccc1)n1cc(-c2nc(Cl)ncc2Cl)c2ccccc21>>CC(C)(C)OC(=O)Nc1ccc(C(=O)N2CCC(Nc3ncc(Cl)c(-c4cn(S(=O)(=O)c5ccccc5)c5ccccc45)n3)CC2)cc1",
        "output": "544"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.CO.F[P-](F)(F)(F)(F)F.NCCO.O.O=C(O)C(F)(F)F.O=C(O)C(O)c1ccc2c(c1)CCc1nc(-c3onc(-c4ccccc4)c3C(F)(F)F)sc1-2>>O=C(NCCO)C(O)c1ccc2c(c1)CCc1nc(-c3onc(-c4ccccc4)c3C(F)(F)F)sc1-2",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)cc1.C[C@]1(C(=O)[C@@H](N)Cc2ccccc2)CO1.F[P-](F)(F)(F)(F)F.O=C(O)C(F)(F)F.On1nnc2ccccc21>>COc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1",
        "output": "645"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.Nc1cc(Cl)ccc1O.O.O=N[O-].[I-].[K+].[Na+]>>Oc1ccc(Cl)cc1I",
        "output": "200"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.COc1cccc(Oc2c(Cl)ncnc2Cl)c1.O=C1CCC(=O)N1Br>>COc1ccc(Br)c(Oc2c(Cl)ncnc2Cl)c1",
        "output": "4"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1cc2c(cc1O)OC(C)(C)C=C2C(C)C.CCCI>>CCCOc1cc2c(cc1C(C)=O)C(C(C)C)=CC(C)(C)O2",
        "output": "198"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CN(C)C=O.Cc1ccc(N)cc1.ClCCCl.N#Cc1ccc(-c2cc(N3CCC[C@H](C(=O)O)C3)nc(N)n2)cc1F.On1nnc2ccccc21>>Cc1ccc(NC(=O)[C@H]2CCCN(c3cc(-c4ccc(C#N)c(F)c4)nc(N)n3)C2)cc1",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CCBr.CN(C)C=O.Oc1ccc(Nc2nccc(-c3cccnc3)n2)cc1.[H-].[Na+]>>C=CCOc1ccc(Nc2nccc(-c3cccnc3)n2)cc1",
        "output": "77"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1NCCc2c(-c3ccnc(F)c3)cccc21.O=C(O)c1cc2ncc(Br)cn2n1>>CN1c2cccc(-c3ccnc(F)c3)c2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "995"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C(=O)/C=C/c1ccc(F)c(Br)c1)C1(C(=O)O)CCN(C(=O)OC(C)(C)C)CC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.NCCc1c[nH]c2ccc(F)cc12>>CN(C(=O)/C=C/c1ccc(F)c(Br)c1)C1(C(=O)NCCc2c[nH]c3ccc(F)cc23)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.ClCCl.NCC1(c2ccc(OCCCN3CCCC3)cc2)CCOCC1.O=C(Cl)Cc1ccccc1>>O=C(Cc1ccccc1)NCC1(c2ccc(OCCCN3CCCC3)cc2)CCOCC1",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)[C@@H]1CCCCN1c1nc2ccccc2s1.[Li+].[OH-]>>O=C(O)[C@@H]1CCCCN1c1nc2ccccc2s1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.C1CCOC1.OCc1cccs1.[H-].[Na+]>>c1ccc(COCc2cccs2)cc1",
        "output": "464"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc([N+](=O)[O-])ccc1OCC(C)(C)OCOCC[Si](C)(C)C.[Pd]>>COc1cc(N)ccc1OCC(C)(C)OCOCC[Si](C)(C)C",
        "output": "202"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CI.CN(C)C=O.O=C1[C@H](Cc2c(Cl)cc(OCc3ccccc3)cc2Cl)CCN1[C@@H]1CC[C@@H](O)CC1.[H-].[Na+]>>CO[C@@H]1CC[C@@H](N2CC[C@@H](Cc3c(Cl)cc(OCc4ccccc4)cc3Cl)C2=O)CC1",
        "output": "140"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)O)cnc21.F[P-](F)(F)(F)(F)F.NCCN1CCOCC1>>Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)NCCN3CCOCC3)cnc21",
        "output": "674"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1CCC(c2c[nH]c3ccc(N)cc23)CC1.COc1cccc(C(=O)O)c1OC>>COc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3c2)c1OC",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1CNCCN1.Clc1ccc2c(Cl)ccnc2c1>>CC1CN(c2ccnc3cc(Cl)ccc23)CCN1",
        "output": "398"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CN(C)C(=O)CN.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COc1cc2c(cc1C(=O)O)nc(Nc1nc3ccc(OC(F)(F)F)cc3s1)n2C.F[P-](F)(F)(F)(F)F>>COc1cc2c(cc1C(=O)NCC(=O)N(C)C)nc(Nc1nc3ccc(OC(F)(F)F)cc3s1)n2C",
        "output": "718"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CN1C(=O)C2CC2(c2ccc([N+](=O)[O-])cc2)C1=O.CCO.[Pd]>>CC(C)CN1C(=O)C2CC2(c2ccc(N)cc2)C1=O",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COC(=O)CCN[C@@H]1CCc2c(-c3noc(-c4ccc(OC(C)C)c(C#N)c4)n3)cccc21.Cl.[Na+].[OH-]>>CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NCCC(=O)O)no2)cc1C#N",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)c1cc(-c2ccnn2C)c(OC)s1.Cl.[Na+].[OH-]>>COc1sc(C(=O)O)cc1-c1ccnn1C",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C[Si](C)(C)I.O=C(N[C@H]1CCCC[C@@H]1OCc1ccccc1)c1nc(-c2ccccc2Cl)n(-c2ccc(Cl)cc2)c1Br>>O=C(N[C@H]1CCCC[C@@H]1O)c1nc(-c2ccccc2Cl)n(-c2ccc(Cl)cc2)c1Br",
        "output": "178"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCCCC.II.OCCCCCCOC1C#CCCCCC1.c1c[nH]cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>ICCCCCCOC1C#CCCCCC1",
        "output": "670"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CC(N)C1.CCN(C(C)C)C(C)C.O=[N+]([O-])c1ccc(F)cc1F>>CC(C)(C)OC(=O)N1CC(Nc2cc(F)ccc2[N+](=O)[O-])C1",
        "output": "572"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc2oc(=O)c(C(=O)O)cc2c1.F[P-](F)(F)(F)(F)F.Nc1cccc(-c2cn3ccccc3n2)c1>>COc1ccc2oc(=O)c(C(=O)Nc3cccc(-c4cn5ccccc5n4)c3)cc2c1",
        "output": "799"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)[C@H]1C2CCC(=O)C21.[Na+].[OH-]>>O=C1CCC2C1[C@H]2C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NCc1ccc(NC(=O)C(C)(C)C)cc1.Cl>>CC(C)(C)C(=O)Nc1ccc(CN)cc1",
        "output": "793"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=CC(=O)NCCCCC[NH3+].CC(C)O.CCN(C(C)C)C(C)C.CO.ClCCl.O=C(Cl)CBr.O=C([O-])C(F)(F)F.O=C=O>>C=CC(=O)NCCCCCNC(=O)CBr",
        "output": "45"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNCC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.NC(=O)c1sc(-n2cnc3ccc(C=O)cc32)nc1-c1cccc(Cl)c1.O=C([O-])[O-].[Cl-].[K+].[K+].[NH4+].[Na+]>>NC(=O)c1sc(-n2cnc3ccc(CN4CCCCC4)cc32)nc1-c1cccc(Cl)c1",
        "output": "567"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)COC(=O)Nc1cccc(Cc2nn(-c3cnn(CCCC(=O)O)c3)ccc2=O)c1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CNC.ClC(Cl)Cl.F[B-](F)(F)F>>CC(C)COC(=O)Nc1cccc(Cc2nn(-c3cnn(CCCC(=O)N(C)C)c3)ccc2=O)c1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "NS(=O)(=O)c1cc(C(=O)O)cc([N+](=O)[O-])c1S(=O)(=O)c1ccccc1.O.[H][H].[Na]>>Nc1cc(C(=O)O)cc(S(N)(=O)=O)c1S(=O)(=O)c1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1=COCCC1.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.Oc1ccc(Cl)cc1Br.c1cc[nH+]cc1>>Clc1ccc(OC2CCCCO2)c(Br)c1",
        "output": "319"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOCCO.COc1ccc2ncc(C#N)c(Cl)c2c1.Cl.Nc1ccc(Cl)cc1F.c1ccncc1>>COc1ccc2ncc(C#N)c(Nc3ccc(Cl)cc3F)c2c1",
        "output": "115"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C(NC1CCC2CC1CCC2O)OCc1ccccc1.[Pd]>>NC1CCC2CC1CCC2O",
        "output": "574"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCS(=O)(=O)c1ccc(Br)cc1.O=C1NCCC12CCN(S(=O)(=O)c1ccccc1Cl)CC2>>CCS(=O)(=O)c1ccc(N2CCC3(CCN(S(=O)(=O)c4ccccc4Cl)CC3)C2=O)cc1",
        "output": "809"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1CCCn2c1cc(Cl)nc2=O.OCc1cc(F)c(Oc2ccc(Cl)c(F)c2)c(F)c1>>CN1CCCn2c1cc(OCc1cc(F)c(Oc3ccc(Cl)c(F)c3)c(F)c1)nc2=O",
        "output": "653"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1C(=O)N(c2nccc(C(F)(F)F)n2)CC1C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CN1C(=O)N(c2nccc(C(F)(F)F)n2)CC1C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)C(=O)CBr.CCOC(=O)c1cc2cc(C(CC)(CC)c3ccc(O)c(C)c3)ccc2o1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cc2cc(C(CC)(CC)c3ccc(OCC(=O)C(C)(C)C)c(C)c3)ccc2o1",
        "output": "221"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCN.O=C(Cl)CN1C(=O)C(NC(=O)OCc2ccccc2)N=C(c2ccccc2)c2ccccc21>>CCCCNC(=O)CN1C(=O)C(NC(=O)OCc2ccccc2)N=C(c2ccccc2)c2ccccc21",
        "output": "45"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(CC(=O)O)C(=O)OC(C)(C)C.CN1CCOCC1.COC(=O)CN.Cl.ClCCl>>COC(=O)CNC(=O)CN(C)C(=O)OC(C)(C)C",
        "output": "129"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.CCOC(=O)C(C)(C)Oc1ccc(O)cc1.CN(C)C(=O)N=NC(=O)N(C)C.OCC(C1CCCCC1)n1c(-c2ccc(Cl)cc2)nc2cc(F)c(F)cc21>>CCOC(=O)C(C)(C)Oc1ccc(OCC(C2CCCCC2)n2c(-c3ccc(Cl)cc3)nc3cc(F)c(F)cc32)cc1",
        "output": "478"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C(C)(c1ccc(C#N)cc1)c1ccc(C(=O)Cc2ccccn2)cc1.CCO.[BH4-].[Na+]>>CC(C)C(C)(c1ccc(C#N)cc1)c1ccc(C(O)Cc2ccccn2)cc1",
        "output": "24"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCc3ccccc3)cc1CC2CC.CO.[Pd]>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2CC",
        "output": "23"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.Cc1cc(-c2ccc(F)c(F)c2)cc(C(=O)Nc2c(F)ccc(O)c2F)c1C>>Cc1cc(-c2ccc(F)c(F)c2)cc(CNc2c(F)ccc(O)c2F)c1C",
        "output": "215"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#Cc1ccc(C)nc1.C1CCOC1.CCN(CC)CC.O.ON=C(Cl)Cc1ccc(COc2ccccn2)cc1>>Cc1ccc(-c2cc(Cc3ccc(COc4ccccn4)cc3)no2)cn1",
        "output": "976"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)c1ccc(N2CCCCC2)c(C(F)(F)F)c1.O.[Li+].[OH-]>>O=C(O)c1ccc(N2CCCCC2)c(C(F)(F)F)c1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)O.CCC1(CC)CC(c2ccc(OC)c(OC)c2)=NN(C2CCNCC2)C1=O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>CCC1(CC)CC(c2ccc(OC)c(OC)c2)=NN(C2CCN(C(=O)[C@@H](Cc3ccccc3)NC(=O)OC(C)(C)C)CC2)C1=O",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cc(N2CCN(C(=O)OC(C)(C)C)CC2)nc(-c2ccnc(NC3CCCCC3)c2)c1C.O=C(O)C(F)(F)F>>CCOC(=O)c1cc(N2CCNCC2)nc(-c2ccnc(NC3CCCCC3)c2)c1C",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)P([c-]1cccc1)C(C)(C)C.COc1ccc(CN(c2ccccc2)c2cc(Cl)nn3ccnc23)cc1.Cc1ccccc1.N#Cc1cc(B(O)O)ccc1F.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].OBO.[Fe+2].[K+].[K+].[K+].[Pd].[Pd].[Pd].c1ccc(-c2c(-c3ccccc3)c(-c3ccccc3)[c-](-c3ccccc3)c2-c2ccccc2)cc1>>COc1ccc(CN(c2ccccc2)c2cc(-c3ccc(F)c(C#N)c3)nn3ccnc23)cc1",
        "output": "866"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.O=C(O)C=Cc1ccc(Cl)cc1.O=S(=O)(O)O.c1ccccc1>>CCOC(=O)C=Cc1ccc(Cl)cc1",
        "output": "174"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCNCCC.O=[N+]([O-])c1cc(C(F)(F)F)cc([N+](=O)[O-])c1Cl>>CCCN(CCC)c1c([N+](=O)[O-])cc(C(F)(F)F)cc1[N+](=O)[O-]",
        "output": "105"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.NN.O.O=[N+]([O-])c1ccc(Oc2cc(F)ccc2F)cc1.[Ni]>>Nc1ccc(Oc2cc(F)ccc2F)cc1",
        "output": "335"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CCO.Cl.NO.O=C1CCN(c2cccc3c2OCCC3)CC1.[Na+]>>ON=C1CCN(c2cccc3c2OCCC3)CC1",
        "output": "86"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)OB(c2ccccc2O)OC1(C)C.CN(C)C=O.COC(=O)CBr.O=C([O-])[O-].[K+].[K+]>>COC(=O)COc1ccccc1B1OC(C)(C)C(C)(C)O1",
        "output": "557"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(N)cc1-c1c(F)cnn1C.O=C=Nc1ccc(Br)cc1>>COc1ccc(NC(=O)Nc2ccc(Br)cc2)cc1-c1c(F)cnn1C",
        "output": "804"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(C#N)(CCO)CC1.CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)N1CCC(C#N)(CCOS(C)(=O)=O)CC1",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.Nc1ccc(Sc2ccccc2)cc1.O=C(Cl)CCCC=C(F)F>>O=C(CCCC=C(F)F)Nc1ccc(Sc2ccccc2)cc1",
        "output": "9"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.NN.O=C(O)CCc1nc(Cc2ccccc2)no1.O=C(n1ccnc1)n1ccnc1>>NNC(=O)CCc1nc(Cc2ccccc2)no1",
        "output": "459"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)Cc2cc(C(=O)O)ccc2NC1c1ccc(F)c(N2CCOCC2)c1.CN(C)C=O.CS(N)(=O)=O.O=C(n1ccnc1)n1ccnc1.[H-].[Na+]>>CC1(C)Cc2cc(C(=O)NS(C)(=O)=O)ccc2NC1c1ccc(F)c(N2CCOCC2)c1",
        "output": "580"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.O=C(Cl)c1ccc(Cl)cc1Cl.O=C1CCNc2cc(Cl)ccc21.c1ccncc1>>O=C1CCN(C(=O)c2ccc(Cl)cc2Cl)c2cc(Cl)ccc21",
        "output": "614"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCO.Cc1cc(CCCCCCCOc2ccc(C(=O)O)cc2)on1>>CCCOC(=O)c1ccc(OCCCCCCCc2cc(C)no2)cc1",
        "output": "33"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)N[C@@H](CSC)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C.O.O=S([O-])OO.[K+]>>COC(=O)N[C@@H](CS(C)(=O)=O)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C",
        "output": "847"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(=O)Cl.CCCNC1Cc2ccccc2C1.ClCCl.O=C([O-])[O-].[Na+].[Na+]>>CCCN(C(=O)CC)C1Cc2ccccc2C1",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#Cc1cnc(N)c(C#N)n1.CC#N.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.FC(F)(F)c1ccc(I)cc1.I[Cu]I>>N#Cc1nc(C#Cc2ccc(C(F)(F)F)cc2)cnc1N",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1cc2cc([N+](=O)[O-])ccc2[nH]1.CCOC(C)=O.[C].[H][H].[Pd]>>CCOC(=O)c1cc2cc(N)ccc2[nH]1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NC1(c2ccc(Br)cc2)CC2(C1)OCCO2.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>NC1(c2ccc(Br)cc2)CC2(C1)OCCO2",
        "output": "793"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COc1ccc(C(=O)c2ccc3cccnc3c2[N+](=O)[O-])cc1.[Pd]>>COc1ccc(C(=O)c2ccc3cccnc3c2N)cc1",
        "output": "269"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=S(=O)(O)Cl.O=[N+]([O-])c1ccccc1O>>O=[N+]([O-])c1cc(S(=O)(=O)Cl)ccc1O",
        "output": "357"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=O.CC#N.CC(=O)O.N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)N5CCC6(CCCCN6)CC5)cc4)cn23)cc1.O=C([O-])O.[BH4-].[Na+].[Na+]>>CN1CCCCC12CCN(C(=O)c1ccc(-c3ccc4ncc(-c5ccc(C#N)cc5)n4c3)cc1)CC2",
        "output": "217"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.Cc1cc(F)ncc1C(=O)O.Cl.OCC1CC1>>Cc1cc(F)ncc1C(=O)OCC1CC1",
        "output": "521"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)O.CN1CCNCC1.[O-][N+]1=C(c2ccccc2)C2=NCCN2c2cc(F)ccc21>>CN1CCN(c2ccc3c(c2)N2CCN=C2C(c2ccccc2)=[N+]3[O-])CC1",
        "output": "26"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cccc(CCN)c1.O=C(O)c1ccc(-c2ccncc2)s1>>Cc1cccc(CCNC(=O)c2ccc(-c3ccncc3)s2)c1",
        "output": "736"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.CS(C)=O.Cc1c[nH]c2ccc(Br)cc12.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1c[nH]c2ccc(B3OC(C)(C)C(C)(C)O3)cc12",
        "output": "942"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)CCN.CO.COC(OC)OC.NC(=O)c1ccc(Oc2ccc3c(c2)CC(C=O)C3)nc1>>CC(C)CCNCC1Cc2ccc(Oc3ccc(C(N)=O)cn3)cc2C1",
        "output": "426"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CCOCC.COC(CC1(C#N)CCCC1)OC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COC(CC1(CN)CCCC1)OC",
        "output": "246"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1ccc(CNCCc2cccc(C(F)(F)F)c2)cc1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[B-](F)(F)F.O.O=C(O)c1cc(Br)cc2cc[nH]c12>>CC(C)(C)c1ccc(CN(CCc2cccc(C(F)(F)F)c2)C(=O)c2cc(Br)cc3cc[nH]c23)cc1",
        "output": "893"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)[Si](OC1CN(C(=O)OCc2ccccc2)CC(O)C1c1ccc(O)cc1)(C(C)C)C(C)C.Fc1ccc(F)c(OCCCBr)c1>>CC(C)[Si](OC1CN(C(=O)OCc2ccccc2)CC(O)C1c1ccc(OCCCOc2cc(F)ccc2F)cc1)(C(C)C)C(C)C",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc(CCNc2ncnc3c(F)ccc(F)c23)cc1C.ClCCl>>Cc1cc(CCNc2ncnc3c(F)ccc(F)c23)ccc1O",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(N)cc1-c1c(Br)cnn1C.ClCCl.O=C=Nc1ccccc1-c1ccccc1>>COc1ccc(NC(=O)Nc2ccccc2-c2ccccc2)cc1-c1c(Br)cnn1C",
        "output": "804"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCNC(=O)c1ccc(-n2nnc(C(=O)NC3CC3)c2CN2C(=O)c3ccccc3C2=O)cc1.CCO.NN.O>>CCNC(=O)c1ccc(-n2nnc(C(=O)NC3CC3)c2CN)cc1",
        "output": "242"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1CCNCC1.O=C(CNS(=O)(=O)c1ccc2ccccc2c1)NC(CNC(=O)C1CCN(c2ccncc2)CC1)C(=O)O>>CC1CCN(C(=O)C(CNC(=O)C2CCN(c3ccncc3)CC2)NC(=O)CNS(=O)(=O)c2ccc3ccccc3c2)CC1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)C(c1ccccc1)c1cc(OCc2ccc3ccccc3n2)ccc1C=O.CC(C)(C)O.CC(C)=C(C)C.O.O.[Na+].[O-][Cl+][O-]>>CC(C)(C)C(c1ccccc1)c1cc(OCc2ccc3ccccc3n2)ccc1C(=O)O",
        "output": "384"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#CCOc1cc(C(=O)O)cc(Cl)c1OCC#C.O=S(Cl)Cl>>C#CCOc1cc(C(=O)Cl)cc(Cl)c1OCC#C",
        "output": "3"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)NCC(=O)c1ccc(O)c(O)c1.COc1c(C)ccc(C(=O)Cl)c1Cl.Cl>>COc1c(C)ccc(C(=O)Oc2ccc(C(=O)CNC(C)C)cc2O)c1Cl",
        "output": "482"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)[O-].CN1C(=O)CC(C(=O)O)C1(C)C.Nc1cc(Cl)cc2c1[nH]c1cnccc12.[NH4+]>>CN1C(=O)CC(C(=O)Nc2cc(Cl)cc3c2[nH]c2cnccc23)C1(C)C",
        "output": "724"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.CCN(CC)CC.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1nc(-c2ccco2)c(N2CCOCC2)s1.O.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CC(C)(C)OC(=O)N1CCC(C(=O)Nc2nc(-c3ccco3)c(N3CCOCC3)s2)CC1",
        "output": "681"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOc1c(C(F)(F)F)cc([N+](=O)[O-])cc1C(F)(F)F.CO.[Pd]>>CCOc1c(C(F)(F)F)cc(N)cc1C(F)(F)F",
        "output": "202"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C(=O)C1CCNCC1.CN1CCCC1=O.Clc1cncc(Cl)c1Cl>>CN(C)C(=O)C1CCN(c2c(Cl)cncc2Cl)CC1",
        "output": "398"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.Nc1ccc(Cl)c(Cl)c1.O=C1OC(=O)C(Br)=C1Br>>O=C1C(Br)=C(Br)C(=O)N1c1ccc(Cl)c(Cl)c1",
        "output": "410"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "B1C2CCCC1CCC2.C1CCOC1.C=CCc1cc(-c2ccc(OC)cc2)c(-c2ccc(OC)cc2)nn1.O.OO.[Na+].[OH-]>>COc1ccc(-c2cc(CCCO)nnc2-c2ccc(OC)cc2)cc1",
        "output": "465"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCN1CCCC1CN.CCOC(=O)Cl.ClC(Cl)Cl.O=C(O)c1cccc2c1OCCC2>>CCN1CCCC1CNC(=O)c1cccc2c1OCCC2",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.COCCO.N#CC(CCBr)(c1ccccc1)c1ccccc1.[Na+].[OH-].c1ccc(C2CCNCC2)cc1>>N#CC(CCN1CCC(c2ccccc2)CC1)(c1ccccc1)c1ccccc1",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCBr.CO.O=C(c1ccc(Cl)cc1)c1ccc(CS)cc1.[K+].[OH-]>>CCSCc1ccc(C(=O)c2ccc(Cl)cc2)cc1",
        "output": "185"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O.O=C1CCC(CCOC2CCCCO2)(c2ccc(Cl)c(Cl)c2)CN1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>Clc1ccc(C2(CCOC3CCCCO3)CCCNC2)cc1Cl",
        "output": "112"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(CC(=O)O)cc1.COc1ccccc1.ClCCl.O.O=S(Cl)Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(CC(=O)c2ccc(OC)cc2)cc1",
        "output": "435"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.ClCCl.FB(F)F.O.O=C(O)Cc1c(Cl)cccc1[N+](=O)[O-].O=C([O-])O.[BH4-].[Na+].[Na+]>>O=[N+]([O-])c1cccc(Cl)c1CCO",
        "output": "231"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(C)(C)CO.CN(C)C=O.N#Cc1cc(Br)ccc1F.[H-].[Na+]>>CCC(C)(C)COc1ccc(Br)cc1C#N",
        "output": "485"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.O=c1ccn(CC(F)(F)F)cc1OCc1ccccc1.[H][H].[Pd]>>O=c1ccn(CC(F)(F)F)cc1O",
        "output": "264"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1C(=O)c2ccccc2OC1(C)C.O=S(=O)(O)O.O=[N+]([O-])O>>CC1C(=O)c2cc([N+](=O)[O-])ccc2OC1(C)C",
        "output": "21"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C1COCCN1.CCN(C(C)C)C(C)C.CCOC(C)=O.O=[N+]([O-])c1ccc(F)c(CBr)c1>>O=[N+]([O-])c1ccc(F)c(CN2CCOCC2)c1",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1ccc(F)c(-c2cc(Nc3ccnc4cn(C5CCNCC5)nc34)ccn2)c1.ClCCl>>Cc1ccc(F)c(-c2cc(Nc3ccnc4cn(C5CCN(S(C)(=O)=O)CC5)nc34)ccn2)c1",
        "output": "584"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCN.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.O=C(O)C=C1CCCc2sccc21.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CCCCNC(=O)C=C1CCCc2sccc21",
        "output": "549"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc(-n2c(C)nc3ccccc32)cc1.[Li+].[OH-]>>Cc1nc2ccccc2n1-c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1cncc(N2CCCNCC2)c1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl>>CC(C)(C)OC(=O)N1CCCN(c2cncc(Br)c2)CC1",
        "output": "694"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1sc(NOC(=O)OC(C)(C)C)nc1C.Cl.OCCC1CCCO1.[K+].[OH-]>>Cc1nc(NOC(=O)OC(C)(C)C)sc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)CNC(=O)c1csc(NC(=O)NCc2ccccc2)n1.CO.Cl.[Na+].[OH-]>>O=C(O)CNC(=O)c1csc(NC(=O)NCc2ccccc2)n1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)c1ccc2c(c1)C=Cc1ccc(C(=O)O)cc1S2(=O)=O.O=C(O)c1ccc2c(c1)S(=O)(=O)c1ccccc1C=C2>>CS(=O)c1ccc2c(c1)C=Cc1ccc(CO)cc1S2(=O)=O",
        "output": "72"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COc1cc(OC)c([C@@H]2CCN(C)[C@H]2COC(C)=O)c(OC)c1.[Na+].[OH-]>>COc1cc(OC)c([C@@H]2CCN(C)[C@H]2CO)c(OC)c1",
        "output": "225"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#Cc1ccc(-c2ccc(Cl)cc2)cn1.CN1CCCN(c2ccc(I)cn2)CC1>>CN1CCCN(c2ccc(C#Cc3ccc(-c4ccc(Cl)cc4)cn3)cn2)CC1",
        "output": "819"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCC.CN(C)C=O.Cc1ccc(Br)c(F)c1.N.N#C[Cu]>>Cc1ccc(C#N)c(F)c1",
        "output": "531"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CS(=O)(=O)Nc1cc([C@@H](O)CN)ccc1O.O=S(=O)(c1cccc(CCCCOCCCCCCBr)c1)C1CCCC1>>CS(=O)(=O)Nc1cc([C@@H](O)CNCCCCCCOCCCCc2cccc(S(=O)(=O)C3CCCC3)c2)ccc1O",
        "output": "147"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCC(C)=O.CS(=O)(=O)c1cccc(C2CCNCC2)c1.Cl.ClCCCl.[Na+]>>CCC(C)N1CCC(c2cccc(S(C)(=O)=O)c2)CC1",
        "output": "187"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=C(Cl)N(C)C.CCN(C(C)C)C(C)C.CN(C)C=O.Cc1nc(C(C)(C)N)no1.Cl.ClCCl.O=C(O)c1cnc(Br)c(-c2cccc(Cl)c2)n1>>Cc1nc(C(C)(C)NC(=O)c2cnc(Br)c(-c3cccc(Cl)c3)n2)no1",
        "output": "697"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.COc1cc(OC)c2c(c1)O/C(=C\\c1c(-c3ccccc3)n(C)c3ccccc13)C2=O.ClCCl>>COc1cc(O)c2c(c1)O/C(=C\\c1c(-c3ccccc3)n(C)c3ccccc13)C2=O",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCN(CCCN)CC2)n1.O=C(O)C1(c2ccc(Cl)cc2)CCCCC1>>CC(C)C(=O)Nc1cccc(C2CCN(CCCNC(=O)C3(c4ccc(Cl)cc4)CCCCC3)CC2)n1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCNc1nc(N)nc(C)c1Cc1ccc(CCl)cc1OC.CCOC(C)=O.CN(C)C=O.CS(C)=O.O=C([O-])O.[C-]#N.[K+].[Na+]>>CCCCNc1nc(N)nc(C)c1Cc1ccc(CC#N)cc1OC",
        "output": "38"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.Nn1c(=O)c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2sccc21.O=Cc1cccc(Br)c1>>O=c1c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2sccc2n1N=Cc1cccc(Br)c1",
        "output": "167"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cl.Nc1c([N+](=O)[O-])ccc2[nH]nnc12>>Nc1ccc2[nH]nnc2c1N",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)O.CCN(CC)CC.CN(C)C=O>>CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)C1CN(C(=O)OC(C)(C)C)c2cc(Cl)c(N(CC)CC)cc2O1.O.O.[Li]O>>CCN(CC)c1cc2c(cc1Cl)N(C(=O)OC(C)(C)C)CC(C(=O)O)O2",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccc2ccccc2c1.CCOC(=O)C=Cc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2O)cc1>>CCOC(=O)C=Cc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCc2ccc3ccccc3c2)cc1",
        "output": "464"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.N#CCBr.O.O=C([O-])[O-].Oc1ccc2nccc(Cl)c2c1.[K+].[K+]>>N#CCOc1ccc2nccc(Cl)c2c1",
        "output": "802"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCc1nc(CC)c(Oc2cc(C)cc(C)n2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1nc(CC)c(Oc2cc(C)cc(C)n2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)c1ccc(O)c(Cl)c1.NN>>NNC(=O)c1ccc(O)c(Cl)c1",
        "output": "421"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1ccc(F)nc1.CS(C)=O.C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(N2C[C@H](C)N(C(=O)OC(C)(C)C)C[C@H]2C)nc1",
        "output": "756"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)Nc1ccccc1[N+](=O)[O-].CCO.[Na+].[OH-].[Zn]>>CC(C)Nc1ccccc1N",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)C(C)(C)C(=O)NCCN1CCOCC1.O.[K+].[OH-]>>CC(C)(C(=O)O)C(=O)NCCN1CCOCC1",
        "output": "281"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCc1ccc(S(=O)(=O)Cl)cc1.Cc1cc(-c2csc(N)n2)ccc1F>>CCCc1ccc(S(=O)(=O)Nc2nc(-c3ccc(F)c(C)c3)cs2)cc1",
        "output": "637"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.Cc1ccc(-c2ccccc2O)cc1.O.O=[N+]([O-])c1ccc(F)cc1.[H-].[Na+]>>Cc1ccc(-c2ccccc2Oc2ccc([N+](=O)[O-])cc2)cc1",
        "output": "564"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.CO.Cl.ClCCl.O=C(O)c1c(O)cnc2ccccc12>>COC(=O)c1c(O)cnc2ccccc12",
        "output": "195"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cc1ccccc1.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.Cc1nc2ccccc2nc1Cl.O.O=C([O-])[O-].OB(O)c1cc(Cl)cc(Cl)c1.[K+].[K+]>>Cc1nc2ccccc2nc1-c1cc(Cl)cc(Cl)c1",
        "output": "875"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CCOCC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)c1ccc(C(C)[NH3+])cc1.F[P-](F)(F)(F)(F)F.O.O=C(O)c1sc(Cl)cc1Cc1cccc(Cl)c1.[Cl-]>>COC(=O)c1ccc(C(C)NC(=O)c2sc(Cl)cc2Cc2cccc(Cl)c2)cc1",
        "output": "950"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCC(=O)N(c1ccc2cc(OC)ccc2c1)C1CCNCC1.CO.ClCCCl.O=C(O)/C=C/C(=O)O.O=C([O-])O.[Na+].[Na+]>>CCC(=O)N(c1ccc2cc(OC)ccc2c1)C1CCN(C)CC1",
        "output": "217"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)CCCN1CCOc2cc(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)ccc2C1.[Na+].[OH-]>>CC(C)Oc1ccc(-c2nc(-c3ccc4c(c3)OCCN(CCCC(=O)O)C4)no2)cc1Cl",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.CO.O=C(O)CCc1ccc(C(F)(F)F)cc1Br>>COC(=O)CCc1ccc(C(F)(F)F)cc1Br",
        "output": "195"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]21.O=C(Cl)c1ccccc1.c1ccncc1>>Cc1ccccc1[C@@H]1[C@@H](O[C@H](COC(=O)c2ccccc2)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]21",
        "output": "51"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCS(=O)(=O)Nc1ccc(F)c(C(=O)O)c1F.CCN=C=NCCCN(C)C.CN(C)C=O.C[C@H]1C[C@H]1c1n[nH]c2ncc(N)cc12.On1nnc2ccccc21>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc([C@@H]4C[C@@H]4C)c3c2)c1F",
        "output": "759"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=C(NC12CCC(Cn3c1nc(C(=O)NCc1ccc(F)cc1)c(O)c3=O)OC2)OCc1ccccc1.[Pd]>>NC12CCC(Cn3c1nc(C(=O)NCc1ccc(F)cc1)c(O)c3=O)OC2",
        "output": "574"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC[C@H]1CCCCCCC(F)(F)C(F)(F)F.Cl>>FC(F)(F)C(F)(F)CCCCCC[C@@H]1CCCN1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(O)Cn1ccc(N)n1.CN(C)C=O.Cc1cccc(C)n1.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)C(CC1CCCC1)c1ccc2c(c1)CCS2(=O)=O>>CC(C)(O)Cn1ccc(NC(=O)C(CC2CCCC2)c2ccc3c(c2)CCS3(=O)=O)n1",
        "output": "795"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CCO.CN(C)c1ccncc1.C[C@@H](C(=O)N1CCC[C@H]1C(=O)O)N(CC(=O)C(Cc1ccccc1)NC(=O)c1ccccc1)C(=O)OCc1ccccc1>>CCOC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N(CC(=O)C(Cc1ccccc1)NC(=O)c1ccccc1)C(=O)OCc1ccccc1",
        "output": "536"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(Cl)Cl.COc1ccc(Cl)c(C)c1.ClCCl.Cl[Ti](Cl)(Cl)Cl>>COc1ccc(Cl)c(C)c1C=O",
        "output": "591"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CO.Cl.NO.O.O=C(CC(O)(c1ccccc1)c1ccccc1)c1ccncc1.[Na+]>>O/N=C(\\CC(O)(c1ccccc1)c1ccccc1)c1ccncc1",
        "output": "212"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1cccc([N+](=O)[O-])c1C.ClC(Cl)(Cl)Cl.ClCCl.O=C1CCC(=O)N1Br>>COC(=O)c1cccc([N+](=O)[O-])c1CBr",
        "output": "545"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)O.COC(=O)c1ccc(Sc2ccc([N+](=O)[O-])cc2C(=O)OC)cc1.ClC(Cl)Cl.[Cl-].[Fe].[NH4+]>>COC(=O)c1ccc(Sc2ccc(N)cc2C(=O)OC)cc1",
        "output": "481"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCBr.CN(C)C=O.Cc1cccc(OCCCCCCCCBr)c1.N#Cc1ccc(O)c(F)c1.[H-].[Na+]>>CCCCCCOc1ccc(C#N)cc1F",
        "output": "75"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C(=O)Cl.C[Si](C)(C)C#N.ClCCl.O=C([O-])[O-].[K+].[K+].[O-][n+]1ccc(-c2ccccc2)cc1>>N#Cc1cc(-c2ccccc2)ccn1",
        "output": "720"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(C)c(C)c(O)c1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.[Cl-].[NH4+].c1ccncc1>>Cc1cc(C)c(C)c(OS(=O)(=O)C(F)(F)F)c1",
        "output": "731"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)C1(Cc2ccccc2)CCC1.O.[Na+].[OH-]>>O=C(O)C1(Cc2ccccc2)CCC1",
        "output": "281"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=Cc1ccc(C(C)(C)C(=O)O)cc1.CCO.[C].[Pd]>>CCc1ccc(C(C)(C)C(=O)O)cc1",
        "output": "555"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.Cc1cc(O)cc(C)c1C=O.ClCCl.c1ccncc1>>CC(=O)Oc1cc(C)c(C=O)c(C)c1",
        "output": "46"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.C[O-].O=C1N(c2ccccc2)CCN1C1CCN(CC(O)COc2nccnc2Cl)CC1.[Na+]>>COc1nccnc1OCC(O)CN1CCC(N2CCN(c3ccccc3)C2=O)CC1",
        "output": "209"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1c(F)ccc(C(Nc2cccc3nc(C)ccc23)C(O)(CSc2ncccn2)C(F)(F)F)c1F.ClCCl>>Cc1ccc2c(NC(c3ccc(F)c(O)c3F)C(O)(CSc3ncccn3)C(F)(F)F)cccc2n1",
        "output": "732"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#Cc1cncnc1.CCN(CC)CC.CN(C)C=O.COC(=O)C(CC1CCCC1)c1ccc(I)cc1.Cl[Pd]Cl.[I-].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)C(CC1CCCC1)c1ccc(C#Cc2cncnc2)cc1",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CN1CCN(CCCNc2ccc([N+](=O)[O-])cc2)CC1.NN.O.[Ni]>>CN1CCN(CCCNc2ccc(N)cc2)CC1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C=CC[C@@H]1[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)N1Cc1ccccc1.CCOC(C)=O.O.O=C(O)[C@@H](O)[C@H](O)C(=O)O.OO.[Na+].[OH-]>>CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)N(Cc2ccccc2)[C@@H]1CCCO",
        "output": "465"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)c1cc2cc(Cl)ncc2[nH]1.[Na+].[OH-]>>O=C(O)c1cc2cc(Cl)ncc2[nH]1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.O=[N+]([O-])c1cccc(F)c1-c1nc2c(F)cncc2s1.[Fe]>>Nc1cccc(F)c1-c1nc2c(F)cncc2s1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Cl.O=[N+]([O-])c1cccc(/C=C/c2ccc3ccccc3n2)c1.[H-].[Na+].[OH-]>>Nc1cccc(/C=C/c2ccc3ccccc3n2)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.CNc1ccc(C(F)(F)F)cn1.O=C1CCC(=O)N1Br.[Cl-].[NH4+]>>CNc1ncc(C(F)(F)F)cc1Br",
        "output": "518"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@H](Cc1cc(F)cc(F)c1)C(=O)O.CCN(C(C)C)C(C)C.CCOC(=O)C(C#N)=NOC(N1CCOCC1)=[N+](C)C.COc1ccc(C2=NN(C3CCNCC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+]>>COc1ccc(C2=NN(C3CCN(C(=O)[C@@H](Cc4cc(F)cc(F)c4)NC(=O)OC(C)(C)C)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCc1cc2c(C(=O)O)ccc(OC)c2o1.Cc1cnn(C)c1N>>COCc1cc2c(C(=O)Nc3c(C)cnn3C)ccc(OC)c2o1",
        "output": "917"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCOC(=O)[C@H](CCCCCCCN)N[C@H]1CSc2ccccc2N(CC(=O)O)C1=O.Cl.Cl.[Na+].[OH-]>>NCCCCCCC[C@H](N[C@H]1CSc2ccccc2N(CC(=O)O)C1=O)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cl.O=[N+]([O-])c1ccc2c(c1)CC(c1c[nH]cn1)C2.[Pd]>>Nc1ccc2c(c1)CC(c1c[nH]cn1)C2",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCC[C@@H](O)[C@@H](CC1CCCCC1)C(=O)OC.CO.O.O.[Li+].[OH-]>>CCC[C@@H](O)[C@@H](CC1CCCCC1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.O.[N-]=[N+]=NCC(O)CN1c2ccccc2CCc2ccc(Cl)cc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NCC(O)CN1c2ccccc2CCc2ccc(Cl)cc21",
        "output": "89"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)C(=CNC1CC1)C(=O)c1c(F)c(OC(F)F)c(F)c(F)c1[N+](=O)[O-]>>CCOC(=O)C(=CNC1CC1)C(=O)c1c(N)c(F)c(F)c(OC(F)F)c1F",
        "output": "202"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCN.CCN(CC)CC.CO.COc1cc2ncnc(Oc3ccc(N)c(C)c3)c2cc1OC.ClC(Cl)Cl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCCCNC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1C",
        "output": "913"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(N)(=O)=O.O=C(O)c1cnn2c(NCC3CCCCC3)c(C(=O)N3CCC(c4ccccc4)CC3)cnc12>>CS(=O)(=O)NC(=O)c1cnn2c(NCC3CCCCC3)c(C(=O)N3CCC(c4ccccc4)CC3)cnc12",
        "output": "991"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(COc2ccc(C(=O)O)cc2)CC1.CC(C)(C)c1ccccc1N1CCNCC1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.Cl.O.O.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCC(COc2ccc(C(=O)N3CCN(c4ccccc4C(C)(C)C)CC3)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Cl.CCOC(=O)C[C@H](N)c1cccc(F)c1.Cl.ClCCl.O>>CCOC(=O)C[C@H](NC(C)=O)c1cccc(F)c1",
        "output": "206"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN.CN(C)C=O.Cl.O.O.O=C(O)c1ccc2cc(Br)ccc2c1.On1nnc2ccccc21>>CNC(=O)c1ccc2cc(Br)ccc2c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CN1CCN(c2ccc(N)cc2)CC1.CO.COc1ccc(Cn2nc3c(Cl)nc4ccccc4c3c2C(F)(F)F)cc1.Cl>>CN1CCN(c2ccc(Nc3nc4ccccc4c4c(C(F)(F)F)[nH]nc34)cc2)CC1",
        "output": "998"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrBr.CC(=O)Nc1ccc2c(c1)CC(NC(C)=O)C2.CC(=O)O>>CC(=O)Nc1cc2c(cc1Br)CC(NC(C)=O)C2",
        "output": "98"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(=O)(=O)Cl.O=Cc1ccc(O)cc1.c1ccncc1>>CS(=O)(=O)Oc1ccc(C=O)cc1",
        "output": "149"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrP(Br)Br.C1CCOC1.COc1cccc(CO)c1>>COc1cccc(CBr)c1",
        "output": "300"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CSc1ncc2cc(-c3c(Cl)ccc(N)c3Cl)c(N)nc2n1.ClCCl.O=C(Cl)c1cccc(C(F)(F)F)c1>>CSc1ncc2cc(-c3c(Cl)ccc(NC(=O)c4cccc(C(F)(F)F)c4)c3Cl)c(N)nc2n1",
        "output": "11"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.COc1cc(CC(C)N)ccc1OCc1ccccc1.Cc1ccc(CC(=O)Cl)cc1.O>>COc1cc(CC(C)NC(=O)Cc2ccc(C)cc2)ccc1OCc1ccccc1",
        "output": "45"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.Cc1cc(C)nc(C)c1.Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(Cl)nc1.OCc1ccccn1.[Cu]I.[H-].[Na+]>>Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc(OCc2ccccn2)nc1",
        "output": "433"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCOC(=O)NCC(=O)O.CO.Cl.O=C([O-])O.[Na+]>>C=CCOC(=O)NCC(=O)OC",
        "output": "17"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COc1ccc(C(=O)O)cc1C#N.Cc1ccccc1.O=S(Cl)Cl>>COc1ccc(C(=O)Cl)cc1C#N",
        "output": "3"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N1CC(N)C1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CC(F)(F)C(=O)N2C.F[P-](F)(F)(F)(F)F>>COc1cc(C(=O)NC2CN(C(C)=O)C2)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.N#CCC(=O)O.Nc1ncnc2c1c(-c1ccc(Oc3c(F)cccc3F)cc1)nn2C[C@H]1CCCN1>>N#CCC(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3c(F)cccc3F)cc2)c2c(N)ncnc21",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COc1ccc(Oc2c(Cl)cc([N+](=O)[O-])cc2Cl)cc1S(=O)(=O)Cl.ClCCl.NC1CCC1>>COc1ccc(Oc2c(Cl)cc([N+](=O)[O-])cc2Cl)cc1S(=O)(=O)NC1CCC1",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)NS(=O)(=O)c1cccc(-c2cc(-c3nc(-c4ccc(Cl)cc4)cc(C(F)(F)F)n3)ccn2)c1.ClCCl.O=C(O)C(F)(F)F>>NS(=O)(=O)c1cccc(-c2cc(-c3nc(-c4ccc(Cl)cc4)cc(C(F)(F)F)n3)ccn2)c1",
        "output": "680"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCC(=O)Cl.CCN(CC)CC.CCOCC.O=[N+]([O-])OCCCO>>CCCCCC(=O)OCCCO[N+](=O)[O-]",
        "output": "126"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.Nc1ccc(F)cc1F.O=C1OC(=O)C2=C1CCCC2>>O=C1C2=C(CCCC2)C(=O)N1c1ccc(F)cc1F",
        "output": "410"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)COc1ccc(Cl)c2nc(OC(C)C)c(Cc3ccc(F)cc3)c(C)c12.O=CO.[Na+].[OH-]>>Cc1c(Cc2ccc(F)cc2)c(OC(C)C)nc2c(Cl)ccc(OCC(=O)O)c12",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-].OCc1ccc(COC2CCCCO2)nc1>>O=Cc1ccc(COC2CCCCO2)nc1",
        "output": "520"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C1COCCOCCOCCOCCO1.CN(Cc1c[nH]c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C.Cc1nnc(-c2cccc(S(=O)(=O)Cl)c2)o1.O.[H-].[Na+]>>Cc1nnc(-c2cccc(S(=O)(=O)n3cc(CN(C)C(=O)OC(C)(C)C)c(F)c3-c3cccnc3F)c2)o1",
        "output": "648"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)OC)N(C)C(=O)[C@@H](NC(=O)C(C)(C)NC)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)C(F)(F)F.O=C(O)CCCN1C(=O)C=CC1=O>>CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)OC)N(C)C(=O)[C@@H](NC(=O)C(C)(C)N(C)C(=O)CCCN1C(=O)C=CC1=O)C(C)C",
        "output": "297"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#C[Si](C)(C)C.CCN(CC)CC.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.I[Cu]I.O=c1c2cc(Br)ccc2ncn1Cc1ccccc1>>C[Si](C)(C)C#Cc1ccc2ncn(Cc3ccccc3)c(=O)c2c1",
        "output": "671"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.C1CCOC1.Cc1cc(-c2nc3c(cc2Br)N(C)C(=O)CO3)ccc1F.Cl>>Cc1cc(-c2nc3c(cc2Br)N(C)CCO3)ccc1F",
        "output": "363"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1c(Cl)cccc1S(=O)(=O)Cl.Cc1nccc(N)n1.c1ccncc1>>Cc1nccc(NS(=O)(=O)c2cccc(Cl)c2C)n1",
        "output": "462"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCOC(=O)c1cn(C2CC2)c2nc3c(F)c(F)c(F)cc3cc2c1=O.CS(C)=O.Cl.c1coc(CN2CCNCC2)c1>>CCOC(=O)c1cn(C2CC2)c2nc3c(F)c(N4CCN(Cc5ccco5)CC4)c(F)cc3cc2c1=O",
        "output": "676"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(OCC(F)(F)F)cn1.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>Cc1ccc(OCC(F)(F)F)c[n+]1[O-]",
        "output": "262"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Cc1ccc(S(=O)(=O)Cl)cc1C(=O)O.ClCCl.O=C(Cl)C(=O)Cl>>Cc1ccc(S(=O)(=O)Cl)cc1C(=O)Cl",
        "output": "448"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Cn1c(SCCOc2ccc(Cl)cc2)nc2ccccc21.ClCCl.O=C(O)C(F)(F)F>>O=C(O)Cn1c(SCCOc2ccc(Cl)cc2)nc2ccccc21",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCCS(=O)(=O)Nc1ccc(F)c(C(O)c2c[nH]c3ncc(Br)cc23)c1>>CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Br)cc23)c1",
        "output": "852"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.O.O=S(=O)(O)O.OC(Cc1ccccc1)c1ccc(Cl)c(Cl)c1>>O=C(Cc1ccccc1)c1ccc(Cl)c(Cl)c1",
        "output": "32"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.O=S1(=O)CCCCN1CCCl.[I-].[Na+]>>O=S1(=O)CCCCN1CCI",
        "output": "97"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NCC1CC1.O=[N+]([O-])c1ccc(F)cc1C(F)(F)F>>O=[N+]([O-])c1ccc(NCC2CC2)cc1C(F)(F)F",
        "output": "572"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCN1.CC(C)O.N#Cc1ccc2nc(Cl)nc(NCc3ccc4c(c3)OCO4)c2c1.O>>N#Cc1ccc2nc(N3CCOCC3)nc(NCc3ccc4c(c3)OCO4)c2c1",
        "output": "36"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCn1cc(-c2ccc(F)c(C)c2)nc1CC(=O)O.CN(C)C=O.ClCCl.O=C([O-])[O-].[K+].[K+].c1cnc(N2CCNCC2)nc1>>CCn1cc(-c2ccc(F)c(C)c2)nc1CC(=O)N1CCN(c2ncccn2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1nc(CCN)cs1.CCN(CC)CC.CN1CCN(C)C1=O.O.O=[N+]([O-])c1ccc(F)cc1>>CC(C)(C)OC(=O)Nc1nc(CCNc2ccc([N+](=O)[O-])cc2)cs1",
        "output": "572"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCN(CCC)S(=O)(=O)c1ccc(C(=O)O)cc1.CN(C)C=O.CN1CCN(c2cccc3c2C[C@H](N)CC3)CC1.O=C(n1ccnc1)n1ccnc1.O=C=O>>CCCN(CCC)S(=O)(=O)c1ccc(C(=O)N[C@@H]2CCc3cccc(N4CCN(C)CC4)c3C2)cc1",
        "output": "835"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N1CCc2ncc([N+](=O)[O-])cc2C1.CO.[Pd]>>CC(=O)N1CCc2ncc(N)cc2C1",
        "output": "269"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc2cnc(F)cc2c1.Cl.O.[Li+].[OH-]>>O=C(O)c1ccc2cnc(F)cc2c1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)c1ccc([N+](=O)[O-])cc1C1CC1.CCO.[C].[Pd]>>CC(C)(C)OC(=O)c1ccc(N)cc1C1CC1",
        "output": "772"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCOC(CN)C1.CCO.CO.ClCCl.ClCCl.N.O=C=Nc1ccc(Cl)cc1>>CC(C)(C)OC(=O)N1CCOC(CNC(=O)Nc2ccc(Cl)cc2)C1",
        "output": "35"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCC1CCC1.CN(C)CCOc1ccc(-n2cnc3cc(CO)sc3c2=O)cc1>>CN(C)CCOc1ccc(-n2cnc3cc(COCC4CCC4)sc3c2=O)cc1",
        "output": "95"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.C[C@H](N)C1CC1.O.O=C1OC[C@H](c2ccccc2)N1c1nc(Cl)ncc1F>>C[C@H](Nc1ncc(F)c(N2C(=O)OC[C@@H]2c2ccccc2)n1)C1CC1",
        "output": "544"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cc(C)c2cc(-c3ccc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)cc3)ccc2n1.CO.Cl.O.[Na+].[OH-]>>Cc1cc(C(=O)O)nc2ccc(-c3ccc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)cc3)cc12",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C(CCCc1cccc(O)c1)OCc1ccccc1.O=C([O-])O.[K+]>>O=C(CCCc1cccc(OCc2ccccc2)c1)OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCNCC1.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.O=C(O)c1cc2cccc(NC(=O)c3cccs3)c2[nH]1.On1nnc2ccccc21>>O=C(Nc1cccc2cc(C(=O)N3CCCCC3)[nH]c12)c1cccs1",
        "output": "605"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Cl.N#Cc1ccc2c(c1)Sc1ccc(Cl)cc1C2.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>Clc1ccc2c(c1)Cc1ccc(-c3nnn[nH]3)cc1S2",
        "output": "390"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN.Cc1ccc(S(=O)(=O)Cl)cc1.O>>CCNS(=O)(=O)c1ccc(C)cc1",
        "output": "43"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.ClCCl.O.O=Cc1cccc(-c2ccco2)c1.[BH4-].[Cl-].[Na+].[Na+]>>OCc1cccc(-c2ccco2)c1",
        "output": "356"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.Cc1ccc(-c2ccc(C(=O)CCC(=O)O)cc2)c([N+](=O)[O-])c1.NC1CCCCC1>>Cc1ccc(-c2ccc(C(O)CCC(=O)O)cc2)c([N+](=O)[O-])c1",
        "output": "24"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCOC(C)=O.Cc1nc(CN2CCN(C(=O)OC(C)(C)C)CC2(C)C)c2cc(C3CCC(C)(C)CC3)sc2n1.Cl>>Cc1nc(CN2CCNCC2(C)C)c2cc(C3CCC(C)(C)CC3)sc2n1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O.CCN(C(C)C)C(C)C.C[Si](C)(C)CCOCCl.ClCCCl.ClCCl>>CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1OCOCC[Si](C)(C)C",
        "output": "375"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)(C)OC(=O)NCCc1cccc(Br)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cl[Pd]Cl.O.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(C)OC(=O)NCCc1cccc(B2OC(C)(C)C(C)(C)O2)c1",
        "output": "942"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN1CCC[C@H]1CO.Clc1cnccn1.[H-].[Na+]>>CN1CCC[C@H]1COc1cnccn1",
        "output": "209"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N.ClCCl.O=C([O-])O.[Al+3].[Cl-].[Cl-].[Cl-].[Na+]>>CS(=O)(=O)N1CCC(Nc2ncc(C(=O)c3c(O)ccc(F)c3F)c(N)n2)CC1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cc1ccc2c(C#C[Si](C)(C)C)cccc2n1.O=C([O-])[O-].[K+].[K+]>>C#Cc1cccc2nc(C)ccc12",
        "output": "337"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)N(CC(O)COc1cccc2[nH]c(C(=O)O)cc12)C(=O)OC(C)(C)C.CCCCc1nc(Cl)c(CN)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1.CN(C)C=O.On1nnc2ccccc21>>CCCCc1nc(Cl)c(CNC(=O)c2cc3c(OCC(O)CN(C(=O)OC(C)(C)C)C(C)C)cccc3[nH]2)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1",
        "output": "137"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.Cc1ccccc1.Nc1ccc(F)cc1.O=C(O)c1c(Cl)cccc1[N+](=O)[O-].O=C([O-])O.O=S(Cl)Cl.[Na+]>>O=C(Nc1ccc(F)cc1)c1c(Cl)cccc1[N+](=O)[O-]",
        "output": "50"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)Cc1c(N)n[nH]c1-c1ccccc1.Cl.O.[Na+].[OH-]>>Nc1n[nH]c(-c2ccccc2)c1CC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=[N+]([O-])c1cccc(C(F)(F)F)c1C(F)(F)F.[Pd]>>Nc1cccc(C(F)(F)F)c1C(F)(F)F",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(C(=O)c2ccc(C)cc2)cc1.OCc1ccccc1-c1cccc2ccccc12.[BH4-].[Na+]>>Cc1ccc(C(O)c2ccc(C)cc2)cc1",
        "output": "157"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O.O=C(OCc1ccccc1)N1CCN(S(=O)(=O)c2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1.[Cl-].[Fe].[NH4+]>>Nc1ccc(S(=O)(=O)N2CCN(C(=O)OCc3ccccc3)CC2)c(C(F)(F)F)c1",
        "output": "401"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.COc1ccc2c(c1)OC[C@@H](c1ccccc1)[C@H]2c1ccc(O)cc1.CS(=O)(=O)Cl.Cl.c1ccncc1>>COc1ccc2c(c1)OC[C@@H](c1ccccc1)[C@H]2c1ccc(OS(C)(=O)=O)cc1",
        "output": "149"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1cc(C)cnc1C1=NC(C)(C(C)C)C(=O)N1C(=O)c1ccccc1.ClC(Cl)(Cl)Cl.ClCCl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)c1cc(CBr)cnc1C1=NC(C)(C(C)C)C(=O)N1C(=O)c1ccccc1",
        "output": "625"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CON(C)C(=O)c1ccc(F)cc1[N+](=O)[O-].[Pd]>>CON(C)C(=O)c1ccc(F)cc1N",
        "output": "486"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.ClCCl.O.Oc1ccc2ccsc2c1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1ccc2ccsc2c1",
        "output": "746"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCl.O.O=C1c2ccccc2C(=O)N1CCO>>O=CCN1C(=O)c2ccccc2C1=O",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "B1C2CCCC1CCC2.C1CCOC1.C=CCCCCc1ccc(Nc2cccc(-c3ccccc3C)c2)cc1.OO.[Na+].[OH-]>>Cc1ccccc1-c1cccc(Nc2ccc(CCCCCCO)cc2)c1",
        "output": "465"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CNc1[nH]nc2c1CCc1nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)cc1-2.O=C(O)C(F)(F)F>>CNc1[nH]nc2c1CCc1nc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)cc1-2",
        "output": "793"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.Clc1ccc2c(I)n[nH]c2n1>>Ic1n[nH]c2nc(N3CCOCC3)ccc12",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=S(=O)(CCCCO)c1cccc(Br)c1.Oc1ccc(F)c(-c2ncnc3c(C(F)(F)F)cccc23)c1>>O=S(=O)(CCCCO)c1cccc(Oc2ccc(F)c(-c3ncnc4c(C(F)(F)F)cccc34)c2)c1",
        "output": "238"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)C=O.CC(C)NC(=O)[C@H]1CCC[C@H]1Nc1nc(Nc2ccc(N3CCC(N4CCNCC4)CC3)cc2)ncc1Cl.CN(C)C=O.[Na+]>>CC(C)CN1CCN(C2CCN(c3ccc(Nc4ncc(Cl)c(N[C@@H]5CCC[C@@H]5C(=O)NC(C)C)n4)cc3)CC2)CC1",
        "output": "484"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.C1COCCO1.Cc1[nH]c2ccc(CCOS(C)(=O)=O)cc2c1C(=O)OCc1ccccc1>>Cc1[nH]c2ccc(CCN3CCCC3)cc2c1C(=O)OCc1ccccc1",
        "output": "496"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.CC(C)=O.COc1cccc(S(=O)(=O)N2CCN(c3ccc(F)cc3C(F)(F)F)C[C@H]2C)c1.ClCCl.O=C=O>>C[C@@H]1CN(c2ccc(F)cc2C(F)(F)F)CCN1S(=O)(=O)c1cccc(O)c1",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCO.Cc1ccc2c(c1)N(CC(=O)C(C)(C)C)C(=O)C(NC(=O)OC(C)(C)C)CN2c1ccccc1.Cl>>Cc1ccc2c(c1)N(CC(=O)C(C)(C)C)C(=O)C(N)CN2c1ccccc1",
        "output": "431"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)Cc1ccc2ccc(C)nc2c1.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>Cc1ccc2ccc(CCO)cc2n1",
        "output": "343"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2ccccc2F)CN1.O=C(O)Cn1cncn1>>O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2ccccc2F)CN1C(=O)Cn1cncn1",
        "output": "297"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.CCCc1c(O)cc(O)c(C)c1C(=O)OC.CCOC(C)=O.ClCCl>>CCCc1c(O)cc(O)c(C)c1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN=C=S.CCO.Cc1nc[nH]c1CSCCN>>CCNC(=S)NCCSCc1[nH]cnc1C",
        "output": "79"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cl.Clc1ccc(OC2CCNCC2)cc1.O=C(Cl)CCl>>O=C(CCl)N1CCC(Oc2ccc(Cl)cc2)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)O)CC1.NCCc1cccc(F)c1>>CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)NCCc2cccc(F)c2)CC1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCNc1nc(C(F)(F)F)ccc1[N+](=O)[O-].CO.[OH-].[OH-].[Pd+2]>>CCNc1nc(C(F)(F)F)ccc1N",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCC1(CCC)CN(Cc2ccccc2)CCC1O.CO.[H][H].[OH-].[OH-].[Pd+2]>>CCCC1(CCC)CNCCC1O",
        "output": "84"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.Cl.Cl[Sn]Cl.O=[N+]([O-])c1ccc(/C=C/c2ccccc2)cc1>>Nc1ccc(/C=C/c2ccccc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C=O)C1.CCO.N#Cc1cnc2ccc(N)cc2c1Nc1ccc(F)c(Cl)c1.[BH3-]C#N.[Na+]>>CC(C)(C)OC(=O)N1CCC(CNc2ccc3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)C1",
        "output": "336"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)c1nc2c(C#N)cccn2c1-c1cccc(O)c1.CCS(=O)(=O)c1cccc(Br)c1>>CCS(=O)(=O)c1cccc(Oc2cccc(-c3c(C(C)(C)C)nc4c(C#N)cccn34)c2)c1",
        "output": "238"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrBr.Cc1ccccc1.O.O=S(=O)(O)O.O=S([O-])O.[Na+].c1ccc2c(c1)Cc1ccccc1-2>>Brc1ccc2c(c1)Cc1ccccc1-2",
        "output": "98"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1cccc(I)c1.Cc1ccccc1.O=C([O-])[O-].OB(O)c1cc2c3ccccc3oc2c2ccccc12.[Na+].[Na+]>>Brc1cccc(-c2cc3c4ccccc4oc3c3ccccc23)c1",
        "output": "855"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CC2C(N)C2C1.CC(C)NC(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(C(=O)O)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nnc(C(F)(F)C(F)(F)C(=O)O)[nH]3)cc2)cc1.F[P-](F)(F)(F)(F)F.O>>Cc1cc(C(=O)NC2C3CN(C(=O)OC(C)(C)C)CC32)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc(-c3nnc(C(F)(F)C(F)(F)C(=O)O)[nH]3)cc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CCS(=O)(=O)Cl.Cc1c(C(=O)NN2CCCCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(O)cc1.ClCCl.O>>Cc1c(C(=O)NN2CCCCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(OS(=O)(=O)CCC(C)C)cc1",
        "output": "149"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.FC(F)c1nc2ccccc2n1-c1nc(NCCSC2CCCC2)nc(N2CCOCC2)n1.O.O=C(OO)c1cccc(Cl)c1>>O=S(CCNc1nc(N2CCOCC2)nc(-n2c(C(F)F)nc3ccccc32)n1)C1CCCC1",
        "output": "13"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.N#Cc1cccc(Br)c1.O>>NC(=O)c1cccc(Br)c1",
        "output": "419"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCO.CSc1n[nH]c2nc(Cl)nc(Nc3ccc(NC(C)=O)cc3)c12.Nc1ccc(N2CCOCC2)cc1>>CSc1n[nH]c2nc(Nc3ccc(N4CCOCC4)cc3)nc(Nc3ccc(NC(C)=O)cc3)c12",
        "output": "808"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COc1cc([N+](=O)[O-])ccc1OCCCN(C)C.Cl.[BH4-].[Na+].[Pd]>>COc1cc(N)ccc1OCCCN(C)C",
        "output": "202"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)Cl.Cc1cccc(N)c1CO.Cl.ClCCl.c1ccncc1>>COC(=O)Nc1cccc(C)c1CO",
        "output": "102"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.COc1cc(Br)cc2ncccc12.N.O>>Oc1cc(Br)cc2ncccc12",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.CN1CCN(CCCO)CC1.COc1cc(F)ccc1[N+](=O)[O-].[H-].[Na+]>>COc1cc(OCCCN2CCN(C)CC2)ccc1[N+](=O)[O-]",
        "output": "485"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc2c(C(=O)O)n[nH]c2c1.Cc1cc(N2CCC(N3CCCC3C)C2)ccc1N>>COc1ccc2c(C(=O)Nc3ccc(N4CCC(N5CCCC5C)C4)cc3C)n[nH]c2c1",
        "output": "844"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.NCCCCN1C(=O)C(c2ccccc2)=C(c2ccccc2)C1=O.O=C(Cl)C(=O)Cl.O=C(O)CCc1cccnc1>>O=C(CCc1cccnc1)NCCCCN1C(=O)C(c2ccccc2)=C(c2ccccc2)C1=O",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)c1ccncc1.CS(=O)(=O)Cl.Nc1cccc(-c2nc3ccc(Br)cc3o2)c1.O>>CS(=O)(=O)Nc1cccc(-c2nc3ccc(Br)cc3o2)c1",
        "output": "194"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1cnc(Cl)nc1.N#CCc1ccc(-c2ncc(C(=O)N(C3CCNCC3)C3CC3)cn2)cc1>>CCc1cnc(N2CCC(N(C(=O)c3cnc(-c4ccc(CC#N)cc4)nc3)C3CC3)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#Cc1ccc(C(C)C(=O)NCC)cc1.C1CCOC1.CC(C)c1ccc(I)cc1.CCC(C)N.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O>>CCNC(=O)C(C)c1ccc(C#Cc2ccc(C(C)C)cc2)cc1",
        "output": "664"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CN(C)P(=O)(N(C)C)N(C)C.COC1(C)Oc2cccc(O)c2O1.ClCc1ccccc1.[H-].[H][H].[Na+]>>COC1(C)Oc2cccc(OCc3ccccc3)c2O1",
        "output": "49"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.CCCCCC.CCOCC.OCc1ccc(CO)o1.[H-].[Na+]>>CC(C)(C)[Si](C)(C)OCc1ccc(CO)o1",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1cnc(Cl)c(I)c1.Clc1ccccc1.O=C1CCC(=O)N1Br>>Clc1ncc(CBr)cc1I",
        "output": "625"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CCN1CCCc2[nH]c(C=O)c(C)c2C1=O.O=C1Cc2c(cccc2-c2cccc(F)c2F)N1>>CCN(CC)CCN1CCCc2[nH]c(/C=C3\\C(=O)Nc4cccc(-c5cccc(F)c5F)c43)c(C)c2C1=O",
        "output": "911"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(N)cnc1OC.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl.c1ccncc1>>COc1cc(NS(=O)(=O)c2ccccc2[N+](=O)[O-])cnc1OC",
        "output": "554"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)CC(O)CC(O)/C=C/C1=C(c2ccc(F)c(C)c2)CC2(CC1(C)C)SCCCS2.[Na+].[OH-]>>Cc1cc(C2=C(/C=C/C(O)CC(O)CC(=O)O)C(C)(C)CC3(C2)SCCCS3)ccc1F",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CN.Nc1cc(F)ccc1C(=O)O.O=C(n1ccnc1)n1ccnc1>>CNC(=O)c1ccc(F)cc1N",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.CCCN1CCNCC1.COC(=O)c1ccc(-c2ccccc2)cc1NC(=O)c1cc(OCCBr)ccc1OCc1ccccc1.Cl.Cl.O=C([O-])[O-].[K+].[K+]>>CCCN1CCN(CCOc2ccc(OCc3ccccc3)c(C(=O)Nc3cc(-c4ccccc4)ccc3C(=O)OC)c2)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccccc1N.O=C(O)c1ccncc1>>COc1ccccc1NC(=O)c1ccncc1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.O=C(O)COc1ccc(F)cc1.O=S(=O)(O)O>>CCOC(=O)COc1ccc(F)cc1",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.O=C(O)[C@@H]1C[C@@H](O)CN1C(=O)OCc1ccc([N+](=O)[O-])cc1>>CS(=O)(=O)O[C@@H]1C[C@@H](C(=O)O)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCCCCCO.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)NCCCCCCO",
        "output": "631"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1ccccc1)c1ccccc1.[K+].[OH-]>>O=C(O)[C@H]1O[C@@H]1C(=O)N(Cc1ccccc1)c1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C[C@@H](CN)c1ccccc1.O=C(O)Cn1nnc2ccccc2c1=O>>C[C@@H](CNC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)=O.CCOc1ccc(Cl)cc1B(O)O.COCCOC.Nc1nc(Cl)cc(Cl)n1.O.O=C([O-])[O-].[Na+].[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOc1ccc(Cl)cc1-c1cc(Cl)nc(N)n1",
        "output": "884"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.CCOC(=O)CCc1ccc(CO)cc1F.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.Oc1cccc2c1N(CCc1ccccc1)CCC2>>CCOC(=O)CCc1ccc(COc2cccc3c2N(CCc2ccccc2)CCC3)cc1F",
        "output": "347"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)c1ccncc1.ClCCCl.NS(=O)(=O)c1ccccc1S(N)(=O)=O.O=C(O)c1ccc(Cl)cc1Cc1ccccc1>>NS(=O)(=O)c1ccccc1S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cc1ccccc1",
        "output": "579"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1cc2oc(=O)cc(-c3ccc(F)cc3)c2cc1C.Cl.[Li+].[OH-]>>Cc1cc2c(-c3ccc(F)cc3)cc(=O)oc2cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CN(C)C=O.Cc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1N.ClCCl.N#Cc1ccc(C(=O)O)c(F)c1F.O=C(Cl)C(=O)Cl.O=C([O-])O.[Na+].c1ccncc1>>Cc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1NC(=O)c1ccc(C#N)c(F)c1F",
        "output": "50"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(C)=O.CS(=O)(=O)Cl.NC(=O)c1ccc(-c2ccccc2F)c2c1[nH]c1cc(CO)ccc12>>CS(=O)(=O)OCc1ccc2c(c1)[nH]c1c(C(N)=O)ccc(-c3ccccc3F)c12",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)CC1OB(O)c2cc(Oc3cnccn3)cc(O)c21.Cl.O.[Li+].[OH-]>>O=C(O)CC1OB(O)c2cc(Oc3cnccn3)cc(O)c21",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1oc2cccc(CO)c2c1C.CI.ClC(Cl)Cl.O=[Ag]>>CCOC(=O)c1oc2cccc(COC)c2c1C",
        "output": "140"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCOC(=O)N1CCc2c(n(C)c3cc(Br)ccc23)CC1.O=c1cc(OCc2ncc(F)cc2F)cc[nH]1>>CCCCOC(=O)N1CCc2c(n(C)c3cc(-n4ccc(OCc5ncc(F)cc5F)cc4=O)ccc23)CC1",
        "output": "982"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCn2c(Br)c(-c3cccc(F)c3)c(C(N)=O)c2C1.ClCCl.O=C(O)C(F)(F)F>>NC(=O)c1c(-c2cccc(F)c2)c(Br)n2c1CNCC2",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)CC(Nc2ncccc2C(=O)Nc2cccc(Cl)c2)CC(C)(C)N1.ClCc1ccccc1.O=C(Nc1cccc(Cl)c1)c1cccnc1N[C@H]1CCCNC1.OCCBr>>O=C(Nc1cccc(Cl)c1)c1cccnc1N[C@H]1CCCN(Cc2ccccc2)C1",
        "output": "156"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN.CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.Cl.Cl.O.O=C(O)c1ccc(N2CCN(Cc3cnc4c(c3)NC(=O)[C@@H]3CSCCN43)CC2)cc1.On1nnc2ccccc21>>CCNC(=O)c1ccc(N2CCN(Cc3cnc4c(c3)NC(=O)[C@@H]3CSCCN43)CC2)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(N)cc1-c1c(Cl)cnn1C(C)C.ClCCl.O=C=Nc1ccc(Cl)cc1>>COc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1-c1c(Cl)cnn1C(C)C",
        "output": "804"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cccc(-c2cn3ccccc3n2)c1.O=C(O)c1cc2cc(O)c(O)cc2oc1=O>>O=C(Nc1cccc(-c2cn3ccccc3n2)c1)c1cc2cc(O)c(O)cc2oc1=O",
        "output": "799"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.Cl.NO.O=Cc1ccc(Cl)cc1.c1ccncc1>>ON=Cc1ccc(Cl)cc1",
        "output": "30"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N[C@H]1CCNC1.CCO.COc1cc2nc(Cl)nc(Cl)c2cc1OC>>COc1cc2nc(Cl)nc(N3CC[C@H](NC(C)=O)C3)c2cc1OC",
        "output": "296"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COc1c(C)c(C)c2c(c1C)CC1(CCC1)CN2c1ccc(Cl)cc1.ClCCl>>Cc1c(C)c2c(c(C)c1O)CC1(CCC1)CN2c1ccc(Cl)cc1",
        "output": "402"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN1CCCC[C@H]1C(=O)O.O=C(c1ccc(F)cc1)C1CCNCC1>>CCN1CCCC[C@H]1C(=O)N1CCC(C(=O)c2ccc(F)cc2)CC1",
        "output": "685"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(C(=O)CC(c2cccc(-c3cccc(C(=O)NCC(=O)O)c3)c2)c2ccccc2C)ccn1.Cl.NO.O=C([O-])O.[Na+]>>Cc1cc(/C(CC(c2cccc(-c3cccc(C(=O)NCC(=O)O)c3)c2)c2ccccc2C)=N/O)ccn1",
        "output": "212"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)COc1nc2ccccc2s1.CO.Cl.[Na+].[OH-]>>O=C(O)COc1nc2ccccc2s1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "N#CC1(C(=O)O)CC1.O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4cnn(C5CCNCC5)c4)cnn23)c1>>N#CC1(C(=O)N2CCC(n3cc(-c4cnn5c(-c6cccc(NC(=O)NCC(F)(F)F)c6)cnc5c4)cn3)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCS(N)(=O)=O.CCOC(=O)c1cc(C#N)c(N2CC(C(=O)O)C2)nc1C(F)F>>CCCCS(=O)(=O)NC(=O)C1CN(c2nc(C(F)F)c(C(=O)OCC)cc2C#N)C1",
        "output": "644"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CC#CC(CC(=O)OC)c1ccc(O)cc1.CC#N.O=C([O-])[O-].[K+].[K+]>>CC#CC(CC(=O)OC)c1ccc(OCc2ccccc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOCC.COC(=O)c1ccc(Cl)n1Cc1ccccc1[N+](=O)[O-].O.[Cl-].[Cl-].[Cl-].[Ti+3]>>COC(=O)c1ccc(Cl)n1Cc1ccccc1N",
        "output": "588"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC1(C)Cc2c(c(C(=O)O)cc3nc(Nc4c(Cl)cncc4Cl)[nH]c23)O1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.NCC1CC1>>CC1(C)Cc2c(c(C(=O)NCC3CC3)cc3nc(Nc4c(Cl)cncc4Cl)[nH]c23)O1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)NC[C@@H]1OC(=O)N2c3ccc(C4=CCN(C(=O)COC(C)=O)CC4)cc3C[C@@H]12.CO.O=C([O-])[O-].[K+].[K+]>>CC(=O)NC[C@@H]1OC(=O)N2c3ccc(C4=CCN(C(=O)CO)CC4)cc3C[C@@H]12",
        "output": "687"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)S(=O)(=O)Cc1cccc(N)c1.Cl.Fc1ccc(-c2nc(Cl)ncc2F)c(F)c1.O=C([O-])O.[Na+]>>CC(C)S(=O)(=O)Cc1cccc(Nc2ncc(F)c(-c3ccc(F)cc3F)n2)c1",
        "output": "808"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CNCCN1.CS(C)=O.Cc1ccc2c(F)cc(F)cc2n1.Cl.O.O=C([O-])[O-].[K+].[K+]>>Cc1ccc2c(N3CCNCC3)cc(F)cc2n1",
        "output": "676"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cc1nc(Cl)c(C#N)cc1-c1ccc2nccn2c1.ClCCl>>COc1nc(C)c(-c2ccc3nccn3c2)cc1C#N",
        "output": "433"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C[Si](C)(C)CCOCN1C(=O)CN(c2cccc(-n3cc(-c4ccc(Cl)cc4Cl)nc3Cc3ccc(-c4ccc(Cl)nn4)cc3)c2)S1(=O)=O.OCC1CCCCC1>>C[Si](C)(C)CCOCN1C(=O)CN(c2cccc(-n3cc(-c4ccc(Cl)cc4Cl)nc3Cc3ccc(-c4ccc(OCC5CCCCC5)nn4)cc3)c2)S1(=O)=O",
        "output": "407"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1cccc(Br)c1.Cc1cc2c(C(F)(F)F)c(C#N)ccc2[nH]1>>Cc1cc2c(C(F)(F)F)c(C#N)ccc2n1Cc1cccc(Br)c1",
        "output": "528"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCC2=NCCCN2CC1.CN(C)CCCN.Nc1ccnc(Cl)n1>>CN(C)CCCNc1nccc(N)n1",
        "output": "544"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(=O)CC1CCc2c1[nH]c1ccc(OCc3ccc(C4CCCCC4)c(C#N)c3)cc21.[Li+].[OH-]>>N#Cc1cc(COc2ccc3[nH]c4c(c3c2)CCC4CC(=O)O)ccc1C1CCCCC1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCO.CCOCC.COCCN(Cc1ccc(-c2cc3nccc(Oc4ccc(N)cc4F)c3s2)nc1)C(=O)OC(C)(C)C.Cc1ccccc1.Cc1ccccc1.O=C(Cc1ccc(F)cc1)N=C=S>>COCCN(Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccc(F)cc5)cc4F)c3s2)nc1)C(=O)OC(C)(C)C",
        "output": "961"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CCc1cc2c(O)c(-c3cc(C)cc(C)c3)c(=O)[nH]c2cc1Cl.CC(C)(C)OC(=O)N1CCCCC1CCO.CCOC(=O)N=NC(=O)OCC.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C=CCc1cc2c(OCCC3CCCCN3C(=O)OC(C)(C)C)c(-c3cc(C)cc(C)c3)c(=O)[nH]c2cc1Cl",
        "output": "478"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(=O)(=O)c1ccc(-c2cn[nH]c(=O)c2-c2ccc(Cl)cc2)cc1.Fc1ccc(Br)cc1F.N>>CS(=O)(=O)c1ccc(-c2cnn(-c3ccc(F)c(F)c3)c(=O)c2-c2ccc(Cl)cc2)cc1",
        "output": "919"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCC(C2CCNCC2)CC1.O=C(O)C(CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)Cc1ccc2c(c1)CCC2>>CN1CCC(C2CCN(C(=O)C(CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)Cc3ccc4c(c3)CCC4)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Nc1cc(-c2c(Nc3ccn(C(=O)OC(C)(C)C)n3)nc3cccnn23)nc(C)n1.ClCCl.O=C(O)C(F)(F)F>>CC(=O)Nc1cc(-c2c(Nc3cc[nH]n3)nc3cccnn23)nc(C)n1",
        "output": "896"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.CC1(C)CCC(=O)Nc2ccc(N)cc21.CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)O)C(=O)C2.CNC(=O)c1cccc(F)c1Nc1nc(Cl)ncc1Cl>>CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)C(C)(C)CCC(=O)N3)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)N=C=O.CN1CCC(c2c[nH]c3ccc(N)cc23)CC1>>CC(C)NC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2c1",
        "output": "176"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.CC(C)(C)[Si](OCCN1CCNCC1)(c1ccccc1)c1ccccc1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.NS(=O)(=O)c1ccc(N[C@@H](CSc2ccccc2)CC(=O)O)c(S(=O)(=O)C(F)(F)F)c1>>CC(C)(C)[Si](OCCN1CCN(C(=O)C[C@H](CSc2ccccc2)Nc2ccc(S(N)(=O)=O)cc2S(=O)(=O)C(F)(F)F)CC1)(c1ccccc1)c1ccccc1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)O.CCOC(=O)CCCOc1cccc(-c2cnc(-c3ccc(CC(C)C)c(C#N)c3)nc2)c1CC.O.[Li+].[OH-]>>CCc1c(OCCCC(=O)O)cccc1-c1cnc(-c2ccc(CC(C)C)c(C#N)c2)nc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCCC.Clc1ccccc1Br.O=Cc1ccc(C(F)(F)F)cc1.[Cl-].[Li]CCCC.[NH4+]>>OC(c1ccc(C(F)(F)F)cc1)c1ccccc1Cl",
        "output": "379"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.COc1cccc(-c2cnc(Nc3ccccc3)o2)c1.ClCCl>>Oc1cccc(-c2cnc(Nc3ccccc3)o2)c1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)CCc1nc(NCc2ccc(OC)c(Cl)c2)c2c(n1)sc1ccccc12.COCCO.Cl.[Na+].[OH-]>>COc1ccc(CNc2nc(CCC(=O)O)nc3sc4ccccc4c23)cc1Cl",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCCc1cc2cc(C#C[Si](C)(C)C)cc(COc3ccc(CCC(=O)OCC)c(C)c3C)c2o1.[F-]>>C#Cc1cc(COc2ccc(CCC(=O)OCC)c(C)c2C)c2oc(CCC)cc2c1",
        "output": "337"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCCCC.CN(C)C=O.COc1cc(OC)c(-c2noc3ccccc23)cc1Br.[Cl-].[Li]CCCC.[NH4+]>>COc1cc(OC)c(-c2noc3ccccc23)cc1C=O",
        "output": "638"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc2cccc(CCN)c2c1.Cl.Cl.ClC(Cl)Cl.O.O=C(Cl)Cc1c[nH]cn1.O=C([O-])[O-].[K+].[K+]>>COc1ccc2cccc(CCNC(=O)Cc3c[nH]cn3)c2c1",
        "output": "45"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CC1.C1CCOC1.CCOC(C)=O.OC1CCNCC1>>OC1CCN(CC2CC2)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)Oc1ccccc1CO.ClCCl.O=[Mn]=O>>CC(C)(C)Oc1ccccc1C=O",
        "output": "179"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C(=O)O)c1ccc([N+](=O)[O-])c(OCc2ccccc2)c1.CO.O=S(=O)(O)O>>COC(=O)C(C)c1ccc([N+](=O)[O-])c(OCc2ccccc2)c1",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)c1c(F)cncc1C1COc2c(cccc2C(N)=O)O1.C[Mg]Br>>CC(C)(O)c1c(F)cncc1C1COc2c(cccc2C(N)=O)O1",
        "output": "586"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CNCCN1.Clc1cc(N2CCCC2)nc(NC23CC4CC(CC(C4)C2)C3)n1>>c1c(N2CCCC2)nc(NC23CC4CC(CC(C4)C2)C3)nc1N1CCNCC1",
        "output": "162"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Clc1ccccc1-c1nnc(C2CCNCC2)o1.O=C(O)C(F)(F)F.O=C(O)CCCc1nc2ccccc2c(=O)[nH]1>>O=C(CCCc1nc2ccccc2c(=O)[nH]1)N1CCC(c2nnc(-c3ccccc3Cl)o2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCC#Cc1ccc(C(=O)OC)cc1C.CO.O.[Na+].[OH-]>>CCCC#Cc1ccc(C(=O)O)cc1C",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.ClCCl.N#Cc1cnc(NC2CCN(C(=O)c3ccc(N)cc3)CC2)nc1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12.[Na+].[OH-]>>N#Cc1cnc(NC2CCN(C(=O)c3ccc(N)cc3)CC2)nc1-c1c[nH]c2ccccc12",
        "output": "771"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc(-c2ccccc2)c(Cl)n1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>Clc1nc(CBr)ccc1-c1ccccc1",
        "output": "590"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cc(Cl)c(N2CCC(C(=O)OC(C)(C)C)CC2)nc1SC.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)c1cc(Cl)c(N2CCC(C(=O)O)CC2)nc1SC",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)CBr.CN(C)C=O.Oc1cc2onc(-c3ccccc3F)c2cc1Cl.[H-].[Na+]>>CCOC(=O)COc1cc2onc(-c3ccccc3F)c2cc1Cl",
        "output": "123"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)CCCC(O)C1.CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OC2CCCC(C)(C)C2)cc1",
        "output": "197"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)C(F)(F)C(F)(F)C(F)(F)S(F)(F)(F)(F)F.COCCOCCOCCOCCOC.O.O=S(=O)(O)O.[BH4-].[Na+]>>OCC(F)(F)C(F)(F)C(F)(F)S(F)(F)(F)(F)F",
        "output": "343"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1sc(N2CCN(c3ccccc3)C2=O)nc1C.COC(=O)c1ccc(CN2CCN(c3nc(C)c(C(C)=O)s3)C2=O)cc1>>CC(=O)c1sc(N2CCN(Cc3ccc(C(=O)O)cc3)C2=O)nc1C",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "N#Cc1cc(C=O)ccc1F.N#Cc1ccc(O)cc1F>>N#Cc1ccc(Oc2ccc(C=O)cc2C#N)cc1F",
        "output": "564"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "NC(=O)C1=CN2C=C3N(C=CC4=CC=CCN43)C=C2C=C1.NCC[C@@H]1CCCCN1.O=C(NCc1ccc(F)cc1F)c1cn2c(c(OCc3ccccc3)c1=O)C(=O)N1CC[C@@H]3CCCCN3[C@@H]1C2>>O=C(NCc1ccc(F)cc1F)c1cn2c(c(O)c1=O)C(=O)N1CC[C@@H]3CCCCN3[C@@H]1C2",
        "output": "264"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N(C)C.CNC(=O)c1cccc(Nc2nc(Cl)ncc2F)c1.Fc1ccc(OC2CNC2)cc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CNC(=O)c1cccc(Nc2nc(N3CC(Oc4ccc(F)cc4)C3)ncc2F)c1",
        "output": "36"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC(O)CN.COc1c(C(=O)O)n(-c2ccccc2)c2ccc(C)cc12>>CCN(CC)CC(O)CNC(=O)c1c(OC)c2cc(C)ccc2n1-c1ccccc1",
        "output": "137"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.Cc1cccc(NC(=O)OC[C@H]2C[C@@H](NS(=O)(=O)c3cc(Br)ccc3Br)CN2)c1.ClCCl.N#CBr.NC(CO)(CO)CO>>Cc1cccc(NC(=O)OC[C@H]2C[C@@H](NS(=O)(=O)c3cc(Br)ccc3Br)CN2C#N)c1",
        "output": "532"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)O.N#CCc1ccc(N)cc1.O=C1CCC(=O)N1Cl>>N#CCc1ccc(N)c(Cl)c1",
        "output": "121"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCNCC.CN(C)C=O.Cl.Nc1ncc(-c2ccn(CC(=O)O)c(=O)c2)c(-c2ccco2)n1.O.On1nnc2ccccc21>>CCN(CC)C(=O)Cn1ccc(-c2cnc(N)nc2-c2ccco2)cc1=O",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc(OC(F)(F)F)ccc1-c1c(C)cc([N+](=O)[O-])c[n+]1[O-].O=P(Cl)(Cl)Cl>>COc1cc(OC(F)(F)F)ccc1-c1nc(Cl)c([N+](=O)[O-])cc1C",
        "output": "2"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.O.O=[N+]([O-])c1ccc2c(cnn2CCN2CCCC2)c1.[Cl-].[Fe].[NH4+]>>Nc1ccc2c(cnn2CCN2CCCC2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(N)C(=O)N1CCc2ccccc2C1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(N)CN1CCc2ccccc2C1",
        "output": "533"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccc(Br)cc1.C1CCOC1.CC(C)OCCO.[H-].[Na+]>>CC(C)OCCOCc1ccc(Br)cc1",
        "output": "464"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc2c(c1)N(C)NCC2.O=C(O)c1cc2ncc(Cl)cn2n1>>Cc1ccc2c(c1)N(C)N(C(=O)c1cc3ncc(Cl)cn3n1)CC2",
        "output": "995"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)/C=C/c1ccc2c(c1)ncn2Cc1ccc2nc(N[C@@H]3CCCC[C@H]3O)sc2c1.[Li+].[OH-]>>O=C(O)/C=C/c1ccc2c(c1)ncn2Cc1ccc2nc(N[C@@H]3CCCC[C@H]3O)sc2c1",
        "output": "122"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1ccc2nc(CC3CCNCC3)oc2c1.CCCc1cnc(Cl)nc1.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCCc1cnc(N2CCC(Cc3nc4ccc(Br)cc4o3)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(C)(C)N.CCO.CS(=O)(=O)c1cc(F)cc(OCCBr)c1>>CCC(C)(C)NCCOc1cc(F)cc(S(C)(=O)=O)c1",
        "output": "147"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCn1cc(C(=O)OC)c2ccccc21.Cl.[Na+].[OH-]>>CCn1cc(C(=O)O)c2ccccc21",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(Cl)Cl.CCOCC.CN(C)C=O.COC(=O)c1cccn1C.ClCCCl.O.O=P(Cl)(Cl)Cl.[Na+]>>COC(=O)c1ccc(C=O)n1C",
        "output": "641"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1ccc(C(F)(F)F)c(C)c1.Cl.[BH4-].[Li+]>>Cc1cc(CO)ccc1C(F)(F)F",
        "output": "444"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccccc1.O=[N+]([O-])c1cnc2cc(OCc3ccccc3)ccc2c1NCCOc1ccccc1.[Pt]>>Nc1cnc2cc(OCc3ccccc3)ccc2c1NCCOc1ccccc1",
        "output": "269"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(=O)c1ccc(CBr)cc1.O=C([O-])[O-].[K+].[K+].c1cn[nH]c1>>CC(=O)c1ccc(Cn2cccn2)cc1",
        "output": "635"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CSc1cc(Oc2ccnc3[nH]c(=O)c(C)nc23)ccc1N.O=C=Nc1cc(C(F)(F)F)ccc1F>>CSc1cc(Oc2ccnc3[nH]c(=O)c(C)nc23)ccc1NC(=O)Nc1cc(C(F)(F)F)ccc1F",
        "output": "912"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-n3nc(Cl)c4ccccc43)nc12.ClCCl.O=C(O)C(F)(F)F>>CC(C)(C)NC(=O)c1c[nH]c2ncc(-n3nc(Cl)c4ccccc43)nc12",
        "output": "981"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCO.COc1cc2nc(Cl)nc(Nc3ccc4[nH]ncc4c3)c2cc1OC.Nc1cccc(F)c1>>COc1cc2nc(Nc3cccc(F)c3)nc(Nc3ccc4[nH]ncc4c3)c2cc1OC",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=C(C)[C@@H]1CC[C@H](CO)CC1.CCBr.CS(C)=O.[H-].[Na+]>>C=C(C)[C@H]1CC[C@@H](COCC)CC1",
        "output": "95"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CSc1cnc(N)s1.CCOC(=O)CSc1cnc(NC(=O)N(CC2CCCC2)c2cccc(F)c2C)s1.CS(=O)(=O)c1ccc(N(CC2CCCC2)C(=O)Nc2nc(CC(=O)O)cs2)cc1.Cc1c(F)cccc1NCC1CCCC1>>Cc1c(F)cccc1N(CC1CCCC1)C(=O)Nc1ncc(SCC(=O)O)s1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Cl.O=C(Cc1ccc([N+](=O)[O-])c(F)c1)N1CCOCC1>>O=[N+]([O-])c1ccc(CCN2CCOCC2)cc1F",
        "output": "112"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OCCNC(=O)[C@@H]1CCCN1C(=O)C1=C(C(C)C)N2C(=N[C@@](C)(c3ccc(Cl)cc3)[C@H]2c2ccc(Cl)cc2)S1.CO.CO.C[O-].[Na+]>>CC(C)C1=C(C(=O)N2CCC[C@H]2C(=O)NCCO)SC2=N[C@@](C)(c3ccc(Cl)cc3)[C@@H](c3ccc(Cl)cc3)N21",
        "output": "225"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCCBr.C1CCOC1.CC(C)c1cccc(Br)c1.Cl.II.O.O=C=O.[Mg]>>CC(C)c1cccc(C(=O)O)c1",
        "output": "654"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COc1c(/C=C/c2ccc(NS(C)(=O)=O)cc2CBr)cc(-c2ccc(C)[nH]c2=O)cc1C(C)(C)C.C[O-].[Na+]>>COCc1cc(NS(C)(=O)=O)ccc1/C=C/c1cc(-c2ccc(C)[nH]c2=O)cc(C(C)(C)C)c1OC",
        "output": "464"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1ccccc1.CCC1(C)CC(NC(=O)c2ccccc2)C(C)C(C)(CC)N1.Cc1ccccc1.O=C([O-])[O-].O=S1(=O)CCCC1.[I-].[K+].[K+].[K+]>>CCC1(C)CC(NC(=O)c2ccccc2)C(C)C(C)(CC)N1Cc1ccccc1",
        "output": "248"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CO.COCCCOc1cc(CC(=O)C2(C)CC2)ccc1Cl.O.[BH3-]C#N.[NH4+].[Na+]>>COCCCOc1cc(CC(N)C2(C)CC2)ccc1Cl",
        "output": "63"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)c1ccncc1.COc1cc(Cl)c(-c2csc(N)n2)c(Cl)c1.Cl.ClCCl.O=C(Cl)c1ccncc1>>COc1cc(Cl)c(-c2csc(NC(=O)c3ccncc3)n2)c(Cl)c1",
        "output": "673"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COCCOCOc1ccc(Cl)cc1CO.CS(=O)(=O)Cl.ClCCl>>COCCOCOc1ccc(Cl)cc1CCl",
        "output": "713"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COc1ccccc1F.O=C=O.[Li]CCCC.[Na+].[OH-]>>COc1cccc(C(=O)O)c1F",
        "output": "387"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COc1cc(OC)cc([Mg]Br)c1.COc1ccc(C=O)cc1[N+](=O)[O-].II.[Mg]>>COc1cc(OC)cc(C(O)c2ccc(OC)c([N+](=O)[O-])c2)c1",
        "output": "309"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "FC(F)(F)c1ccc(-c2cc(CCl)on2)cc1.Nc1n[nH]cc2nc(-c3cccc(F)c3F)nc1-2>>Nc1nn(Cc2cc(-c3ccc(C(F)(F)F)cc3)no2)cc2nc(-c3cccc(F)c3F)nc1-2",
        "output": "997"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N[C@H](CO)CC(=O)OCc1ccccc1.CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CN(C)C=O.O.c1c[nH]cn1>>CC(C)(C)OC(=O)N[C@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)CC(=O)OCc1ccccc1",
        "output": "602"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(Cc1ccc(O)c2ccoc12)C(=O)OC.Cc1oc(-c2ccc(C(C)(C)C)cc2)nc1CCl.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CCOC(Cc1ccc(OCc2nc(-c3ccc(C(C)(C)C)cc3)oc2C)c2ccoc12)C(=O)OC",
        "output": "760"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cc1ccc(-c2ccc(C3(c4nnc5n4CCSC(C)(CO[Si](C)(C)C(C)(C)C)C5)CC3)cc2)cc1.Cl>>Cc1ccc(-c2ccc(C3(c4nnc5n4CCSC(C)(CO)C5)CC3)cc2)cc1",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CCN(CC)CCNC(=O)c1c[nH]c(C=O)c1C.CCO.O=C1Cc2c(cccc2-c2ccc(Cl)cc2)N1>>CCN(CC)CCNC(=O)c1c[nH]c(C=C2C(=O)Nc3cccc(-c4ccc(Cl)cc4)c32)c1C",
        "output": "440"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.COC(=O)c1cnc(Cl)cc1C(F)(F)F.FC(F)(F)c1cc(C(F)(F)F)cc(C2(C(F)(F)F)CCNC2)c1.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cnc(N2CCC(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(C(F)(F)F)C2)cc1C(F)(F)F",
        "output": "220"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCOCC.CN(C)c1ccncc1.COC1CC(CN)C(OC)O1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>COC1CC(CNC(=O)C(F)(F)F)C(OC)O1",
        "output": "316"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#CCOc1cnc(C(=O)OC)c(C)c1.C1CCOC1.CC(C)O.Cl.ClC(Cl)Cl.O.O.O.[Cl-].[Li+].[Na+].[OH-]>>C#CCOc1cnc(C(=O)O)c(C)c1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCN(CCn2cnc(-c3cc4nccc(Oc5ccc(NC(=O)NC6CC6)cc5F)c4s3)c2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(Nc1ccc(Oc2ccnc3cc(-c4cn(CCN5CCNCC5)cn4)sc23)c(F)c1)NC1CC1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#CCOCCn1c(CCOC)nc2cnc3ccccc3c21.Ic1ccccc1>>COCCc1nc2cnc3ccccc3c2n1CCOCC#Cc1ccccc1",
        "output": "664"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC=C1CC2C(=O)N(COCC[Si](C)(C)C)c3cc(OCCCO[Si](C)(C)C(C)(C)C)c(OC)cc3C(=O)N2C1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>CC=C1CC2C(=O)N(COCC[Si](C)(C)C)c3cc(OCCCO)c(OC)cc3C(=O)N2C1",
        "output": "708"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1n[nH]c2cc(Br)ccc12.O=C(Cl)C1CC1.c1ccncc1>>O=C(Nc1n[nH]c2cc(Br)ccc12)C1CC1",
        "output": "527"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CNCCCOC.COc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)O)cn2)c1O>>COCCCN(C)C(=O)c1ccc(-n2ncc(-c3ccc(C#N)cc3OC)c2O)nc1",
        "output": "256"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)[O-].CCOC(C)Oc1ccc2cc(C=O)ccc2c1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.O.[Br-].[K+]>>C=Cc1ccc2cc(OC(C)OCC)ccc2c1",
        "output": "649"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)C(CC)C(C)=O.O.[Na+].[OH-]>>CCC(C(C)=O)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(Cl)Cl.CCN=C=NCCC[N+](C)(C)C.CN(C)C=O.Cc1cc(-c2cc(-c3cccc(OCC(=O)O)c3)[nH]c(=O)n2)ccc1O.NCCCN1CCOCC1.On1nnc2ccccc21.[I-]>>Cc1cc(-c2cc(-c3cccc(OCC(=O)NCCCN4CCOCC4)c3)[nH]c(=O)n2)ccc1O",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1ccc2c(c1)CCC2.CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.CO.ClCCl.[Br-].[Br-].[Br-]>>O=C(CBr)c1ccc2c(c1)CCC2",
        "output": "360"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#Cc1cccc(N)c1.ClCCl.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>C#Cc1cccc(NC(=O)C(F)(F)F)c1",
        "output": "106"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cl.F[B-](F)(F)F.NCc1ccc(C(F)(F)F)nc1-c1ccc(F)c(Cl)c1.O=C(O)Cc1ccccn1>>O=C(Cc1ccccn1)NCc1ccc(C(F)(F)F)nc1-c1ccc(F)c(Cl)c1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)N1CCNCC1.Cc1cc(Cl)nc(Cl)n1>>Cc1cc(Cl)nc(N2CCN(S(C)(=O)=O)CC2)n1",
        "output": "36"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)Oc1ccc(COc2ccc3c(c2)c(S(C)(=O)=O)c2n3CCC2CC(=O)OC(C)(C)C)cc1C#N.CCOC(C)=O.ClCCl.N[C@@H](CS)C(=O)O.O.O=C(O)C(F)(F)F>>CC(C)Oc1ccc(COc2ccc3c(c2)c(S(C)(=O)=O)c2n3CCC2CC(=O)O)cc1C#N",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCOC(C)=O.COCCOc1cccc(N)c1.Fc1ccc(Oc2ccc(Cl)nc2)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>COCCOc1cccc(Nc2ccc(Oc3ccc(F)cc3)cn2)c1",
        "output": "434"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1ncc2c(cc(-c3ccccc3)c(=O)n2CC2CCCC2)c1O.C[O-].NCCC(=O)O.O=C([O-])O.[Na+].[Na+]>>O=C(O)CCNC(=O)c1ncc2c(cc(-c3ccccc3)c(=O)n2CC2CCCC2)c1O",
        "output": "487"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "NC(=O)c1ncn(C2CCCC2)c1N.O=C(Cl)CCl>>NC(=O)c1ncn(C2CCCC2)c1NC(=O)CCl",
        "output": "399"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN.CCO.Cl.ClCCl.Nc1c(Cl)ncnc1Cl.O=C([O-])[O-].[K+].[K+]>>CCNc1ncnc(Cl)c1N",
        "output": "110"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(OC)c1ncccc1CO.Cc1ccccc1.O=[Mn]=O>>COC(OC)c1ncccc1C=O",
        "output": "520"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.Fc1ccc(CN2CCNCC2)cc1.O=C=NCc1ccc(Cl)cc1Cl>>O=C(NCc1ccc(Cl)cc1Cl)N1CCN(Cc2ccc(F)cc2)CC1",
        "output": "583"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CI.O=C([O-])[O-].O=[N+]([O-])c1ccc(O)cc1C(F)(F)F.[K+].[K+].c1ccccc1>>COc1ccc([N+](=O)[O-])c(C(F)(F)F)c1",
        "output": "62"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCNCC2)cc1F.Cl.O=Cc1ccc(Cl)cc1C(F)(F)F>>CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(Cc3ccc(Cl)cc3C(F)(F)F)CC2)cc1F",
        "output": "567"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC=O.COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCNCc2ccc3ccccc3c2)CC1.[BH3-]C#N.[Na+]>>CCN(CCCCCN1CCC(CNC(=O)c2cc(Cl)c(N)cc2OC)CC1)Cc1ccc2ccccc2c1",
        "output": "858"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CNCC[C@@H]1CC[C@@H](COS(C)(=O)=O)CC1.Cl.O=S(=O)(Cl)c1ccc(Cl)cc1>>CN(CC[C@@H]1CC[C@@H](COS(C)(=O)=O)CC1)S(=O)(=O)c1ccc(Cl)cc1",
        "output": "99"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1sc(N2CCN(CC(C)C)C2=O)nc1C.CCOC(=O)c1sc(N2CCN(CC3CC3(F)F)C2=O)nc1C>>Cc1nc(N2CCN(CC(C)C)C2=O)sc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCC(CN)(c2cccc(-c3ccccc3)c2)CC1.O=C(O)c1cccc(-c2noc(C(F)(F)F)n2)c1>>CN1CCC(CNC(=O)c2cccc(-c3noc(C(F)(F)F)n3)c2)(c2cccc(-c3ccccc3)c2)CC1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(O)CCO.CCCC[Sn](=O)CCCC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCCC(C)O)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[O-].CCOC(C)=O.CS(C)=O.Cl.O=C(O)c1cnc(Cl)c(Cl)c1.OCC12CC3CC(CC(C3)C1)C2.[K+]>>O=C(O)c1cnc(OCC23CC4CC(CC(C4)C2)C3)c(Cl)c1",
        "output": "433"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(CO)CCCN(C(=O)OC(C)(C)C)C1.CCN(CC)CC.CCOCC.CS(C)=O.ClCCl>>CC1(C=O)CCCN(C(=O)OC(C)(C)C)C1",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)COCCOCCOCCOS(=O)(=O)c1ccc(C)cc1.CO.Cl.O.[Na+].[OH-]>>Cc1ccc(S(=O)(=O)OCCOCCOCCOCC(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrP(Br)Br.COc1ccc(CO)c(OC)c1OC.ClCCl>>COc1ccc(CBr)c(OC)c1OC",
        "output": "300"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1c(C)nc2cccc(OC[C@H](C)N)c2c1N.COc1ccc(C(=O)O)cc1OCCO>>CCOC(=O)c1c(C)nc2cccc(OC[C@H](C)NC(=O)c3ccc(OC)c(OCCO)c3)c2c1N",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.NCC1CCOCC1.NS(=O)(=O)c1cc(F)c(F)cc1Cl>>NS(=O)(=O)c1cc(F)c(NCC2CCOCC2)cc1Cl",
        "output": "572"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCCCOc1ccc(C=O)c2ccccc12.NCc1ccc(C(F)(F)F)cc1>>CCCCCCCCCCCCOc1ccc(CNCc2ccc(C(F)(F)F)cc2)c2ccccc12",
        "output": "683"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCc1cc(F)c(F)c([C@H](O)CO)c1.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>CCOC(=O)CCc1cc(F)c(F)c([C@H](O)COS(=O)(=O)c2ccc(C)cc2)c1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.ClCCCc1cc2ccccc2s1.O=S([O-])([O-])=S.[I-].[Na+].[Na+].[Na+]>>ICCCc1cc2ccccc2s1",
        "output": "97"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COc1cc(CO)ccc1[N+](=O)[O-].[H][H].[Pd]>>COc1cc(CO)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(=O)(=O)OCCc1cccc([N+](=O)[O-])c1.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1.O=[N+]([O-])c1cccc(CCO)c1>>O=[N+]([O-])c1ccc(S(=O)(=O)OCCc2cccc([N+](=O)[O-])c2)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C1CCc2cc(OCCCCBr)ccc2N1.Oc1ccc(S)cc1>>O=C1CCc2cc(OCCCCSc3ccc(O)cc3)ccc2N1",
        "output": "124"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Nc1ccc(Br)c2c1CCCC2.CN(C)C=O.N#C[Cu]>>CC(=O)Nc1ccc(C#N)c2c1CCCC2",
        "output": "531"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.NO.O=Cc1ccc(Cl)c(I)c1F>>ON=Cc1ccc(Cl)c(I)c1F",
        "output": "30"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCCc1nc2ccc(C(O)CC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.CI.[H-].[Na+]>>CCCCc1nc2ccc(C(CC)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1",
        "output": "140"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)C1CN(S(=O)(=O)c2cc3cc(Cl)ccc3[nH]2)CCN1C(=O)c1ccc(C=NN(C)C)cc1.O.O.[Li]O>>CN(C)N=Cc1ccc(C(=O)N2CCN(S(=O)(=O)c3cc4cc(Cl)ccc4[nH]3)CC2C(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cc1cc(Br)ccc1CBr.[H-].[Na+].c1c[nH]cn1>>Cc1cc(Br)ccc1Cn1ccnc1",
        "output": "593"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.C1CCC2=NCCCN2CC1.C1CCOC1.CC(C)n1c(C=O)c(-c2ccc(F)cc2)c(-c2ccc(F)cc2)c1C(=O)O>>CC(C)n1c(C=O)c(-c2ccc(F)cc2)c(-c2ccc(F)cc2)c1C(=O)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.Cl.Oc1ccc(Cl)c(Cl)c1.c1ccncc1>>CC(=O)Oc1ccc(Cl)c(Cl)c1",
        "output": "46"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)c1ccccc1COCC(Cc1ccccc1)NC(=O)OC(C)(C)C.Cl.[Na+].[OH-]>>CC(C)(C)OC(=O)NC(COCc1ccccc1C(=O)O)Cc1ccccc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CN2CCN1CC2.O=C=Nc1ccc(C(F)(F)F)cc1.OCc1cccnc1.c1ccccc1>>O=C(Nc1ccc(C(F)(F)F)cc1)OCc1cccnc1",
        "output": "34"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(CCO)c1ccc([N+](=O)[O-])c(N(C)C(=O)OC(C)(C)C)c1.CO>>CN(CCO)c1ccc(N)c(N(C)C(=O)OC(C)(C)C)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.CNOC.Cl.Cl.O.O=C(O)Cc1ccc(Cl)nc1>>CON(C)C(=O)Cc1ccc(Cl)nc1",
        "output": "54"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Cl.CC(C)(C)OC(=O)NC1CCNC1.CCN(CC)CC.ClCCl>>CC(=O)N1CCC(NC(=O)OC(C)(C)C)C1",
        "output": "125"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCC.CCOC(C)=O.COc1ccc(C(=O)Cl)cc1C(F)(F)F.Cc1ccc2nc(-c3ccc(N)cc3)cn2c1.c1ccncc1>>COc1ccc(C(=O)Nc2ccc(-c3cn4cc(C)ccc4n3)cc2)cc1C(F)(F)F",
        "output": "11"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.NO.O.O=[N+]([O-])c1ccc(S(=O)(=O)N2CCCCC2)cc1.[Cl-].[Fe].[NH4+]>>Nc1ccc(S(=O)(=O)N2CCCCC2)cc1",
        "output": "401"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)CCC[C@@H](C)CC(=O)O.O=C(Cl)C(=O)Cl.c1ccccc1>>CC(C)CCC[C@@H](C)CC(=O)Cl",
        "output": "56"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.COC(=O)c1cc(N(CC2CC2)C2CCCCC2)ncn1.O.O.[Li+].[OH-]>>O=C(O)c1cc(N(CC2CC2)C2CCCCC2)ncn1",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.COC(=O)/C(=C/c1ccccc1)CCl.Cl>>O=C(O)/C(=C/c1ccccc1)CCl",
        "output": "58"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)c1ccc(N)c(N)c1.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.CCOC(C)=O.C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)O.O=C([O-])O.[Na+]>>C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)c1nc2cc(C(C)(C)C)ccc2[nH]1",
        "output": "512"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCn1c(C)cc(=O)[nH]c1=O.CCOC(C)=O.CI.CN(C)C=O.ClCCl.O=C([O-])[O-].[K+].[K+]>>CCCCn1c(C)cc(=O)n(C)c1=O",
        "output": "570"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(CC)CCl.CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.O=C([O-])[O-].O=Cc1cc(Cl)ccc1O.[I-].[K+].[K+]>>CCC(CC)COc1ccc(Cl)cc1C=O",
        "output": "74"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CN(C)C=O.Clc1ccc(-c2csc(Br)n2)c(Cl)c1.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccc(Cl)cc3Cl)cs2)CC1",
        "output": "657"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)CCNS(=O)(=O)c1cccc(C(=O)O)c1.Cl.Nc1nc(N)c(C(=O)/N=C2\\NCC3(CCNCC3)N2)nc1Cl>>CC(C)(C)OC(=O)CCNS(=O)(=O)c1cccc(C(=O)N2CCC3(CC2)CN/C(=N\\C(=O)c2nc(Cl)c(N)nc2N)N3)c1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CC(C)(CNc1c([N+](=O)[O-])cnc2cccnc12)NC(=O)OC(C)(C)C.[H][H].[Pt]>>CC(C)(CNc1c(N)cnc2cccnc12)NC(=O)OC(C)(C)C",
        "output": "269"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)[C@@H]1CCCN1C(=O)c1cccc2ccccc12.ClCCl.O=C(O)C(F)(F)F>>O=C(O)[C@@H]1CCCN1C(=O)c1cccc2ccccc12",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)CC(C2CCNCC2)C(=O)N1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cl.F[B-](F)(F)F.O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1>>CC1(C)CC(C2CCN(C(=O)c3ccc(N4CC(F)(F)C4)c(OCC4CC4)n3)CC2)C(=O)N1",
        "output": "605"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)c2ccn(-c3ccccc3N)c2-c2ccccc2)[C@H](Cc2ccccc2)C1.CN(C)C=O.COCCCBr.O=C([O-])O.O=C([O-])[O-].[Ca+2].[Na+]>>COCCCNc1ccccc1-n1ccc(C(=O)N2CCN(C(=O)OC(C)(C)C)C[C@H]2Cc2ccccc2)c1-c1ccccc1",
        "output": "273"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.CN1CC[C@@H](O)C1.O.O=C(O)[C@](O)(c1ccccc1)C1CCCC1>>CN1CC[C@@H](OC(=O)[C@](O)(c2ccccc2)C2CCCC2)C1",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.Cc1ccc([N+](=O)[O-])c(C(=O)O)c1>>Cc1ccc([N+](=O)[O-])c(CO)c1",
        "output": "72"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCOc1cc([N+](=O)[O-])ccc1N.O.O=C1OC(=O)c2ccccc21>>CCOc1cc([N+](=O)[O-])ccc1N1C(=O)c2ccccc2C1=O",
        "output": "475"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(c1cc(C(=O)O)ncn1)C1CCCCC1.Nc1ccc2[nH]ncc2c1>>CN(c1cc(C(=O)Nc2ccc3[nH]ncc3c2)ncn1)C1CCCCC1",
        "output": "548"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(=O)(=O)Cl.Cl.O.O=C(O)c1ccc(O)cc1Cl.[Na+].[OH-]>>CS(=O)(=O)Oc1ccc(C(=O)O)c(Cl)c1",
        "output": "149"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCCOc1ccccc1Br.CC(C)O.NCCO>>OCCNCCOc1ccccc1Br",
        "output": "147"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CN(CCN2CCOCC2)CCN1.Cc1nc(N)cc(Cl)n1>>Cc1nc(N)cc(N2CCN(CCN3CCOCC3)CC2)n1",
        "output": "162"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CCN(C(C)C)C(C)C.CCO.Fc1cnc(Cl)nc1Cl>>Fc1cnc(Cl)nc1N1CCOCC1",
        "output": "162"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(Br)cc1F>>O=C(Cl)c1ccc(Br)cc1F",
        "output": "448"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.C1COCCO1.CC(C)OC(=O)N1CCC(O[C@H](C)C(=O)O)C1.CCN=C=NCCCN(C)C.N.On1nnc2ccccc21>>CC(C)OC(=O)N1CCC(O[C@H](C)C(N)=O)C1",
        "output": "313"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N(C)c1ccc(N2C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)[C@@H]3CCCC[C@H]32)cc1F.Cl.O=C([O-])O.[Na+]>>CNc1ccc(N2C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)[C@@H]3CCCC[C@H]32)cc1F",
        "output": "504"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.N#Cc1ccc(CO)cn1.O.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCc1ccc(C#N)nc1",
        "output": "193"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Br.CCN(C(C)C)C(C)C.CN(C)C=O.NCc1ccc(Cl)nn1.O=[N+]([O-])c1ccc(Br)cc1F>>O=[N+]([O-])c1ccc(Br)cc1NCc1ccc(Cl)nn1",
        "output": "572"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CNCCCCCCCCCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1.Cl.Cl.Nc1c(F)c(N)c(F)c(F)c1F.O=Cc1cc(F)ccc1O>>CN(CCCCCCCCCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Cc1cc(F)ccc1O",
        "output": "567"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#Cc1ccccc1OC.CC(C)(C)OC(=O)N1CCC(c2ccc(N)c(I)c2)CC1.CCN(CC)CC.[Cu]I>>COc1ccccc1C#Cc1cc(C2CCN(C(=O)OC(C)(C)C)CC2)ccc1N",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CNOC.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O.O=C(O)c1cnccc1C(F)(F)F>>CON(C)C(=O)c1cnccc1C(F)(F)F",
        "output": "879"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)N1CCC(CC(=O)Nc2cc(Br)ccn2)CC1.Cc1ccc(B(O)O)cc1>>CC(=O)N1CCC(CC(=O)Nc2cc(-c3ccc(C)cc3)ccn2)CC1",
        "output": "872"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#Cc1ccccc1.CC(C)c1cc(Br)ccc1OC(F)F.CCN(CC)CC.CN(C)C=O.Cl[Pd]Cl.[Cu]I.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)c1cc(C#Cc2ccccc2)ccc1OC(F)F",
        "output": "659"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(CC)CC.C[C@@H](N1CCNCC1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F.O=C(Cl)c1ccc(F)cc1F>>C[C@@H](N1CCN(C(=O)c2ccc(F)cc2F)CC1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F",
        "output": "201"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(C)=O.O=C(Cl)c1ccc([N+](=O)[O-])cc1O.c1ccc(CC2CCNCC2)cc1>>O=C(c1ccc([N+](=O)[O-])cc1O)N1CCC(Cc2ccccc2)CC1",
        "output": "201"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)Cc1c(Cl)cc(C)cc1OC.O.[K+].[OH-]>>COc1cc(C)cc(Cl)c1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc2c(-c3ccc(Cl)cc3)nnc(Cl)c2c1.NC1CCN(Cc2ccc3ccccc3c2)CC1>>COc1ccc2c(-c3ccc(Cl)cc3)nnc(NC3CCN(Cc4ccc5ccccc5c4)CC3)c2c1",
        "output": "241"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)c1ccncc1.ClCCCl.ClCCl.O=C(O)CC1SCCN1C(=O)c1ccccc1.[O-][n+]1cc(Cl)c(C[C@H](O)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1>>O=C(CC1SCCN1C(=O)c1ccccc1)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)c1ccc(NC(=O)Cn2c3c(c(-c4cc(Cl)ccc4C#N)cc2=O)C(=O)CC3)cc1.O=C(O)C(F)(F)F>>N#Cc1ccc(Cl)cc1-c1cc(=O)n(CC(=O)Nc2ccc(C(=O)O)cc2)c2c1C(=O)CC2",
        "output": "752"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)c1cccc(C(C)C)c1Br.Cl.O=C=O.[Li]CCCC>>CC(C)c1cccc(C(C)C)c1C(=O)O",
        "output": "654"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(O)Cc1cccc(Cl)c1.O=S(Cl)Cl>>O=C(Cl)Cc1cccc(Cl)c1",
        "output": "53"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C1CCc2[nH]c3ccc(N)cc3c2C1.Cc1cccc(C(=O)Cl)c1>>Cc1cccc(C(=O)Nc2ccc3[nH]c4c(c3c2)CC(N(C)C)CC4)c1",
        "output": "11"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CN(C)C(=O)[C@@H]1Cc2ccccc2[C@@H]1NC(=O)OC(C)(C)C.ClCCl.[Br-].[Br-].[Zn+2]>>CN(C)C(=O)[C@@H]1Cc2ccccc2[C@@H]1N",
        "output": "793"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(C)Oc1cccc(CC(=O)OC)c1.CO.[Na+].[OH-]>>CCC(C)Oc1cccc(CC(=O)O)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(N)(C#N)Cn1nc2c(Cl)cc(Cl)c(Cl)c2n1.N#Cc1ccc(C(=O)Cl)cc1>>CC(C#N)(Cn1nc2c(Cl)cc(Cl)c(Cl)c2n1)NC(=O)c1ccc(C#N)cc1",
        "output": "271"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "N[C@H]1CCNC1.O=C(CC1CCCCC1)Nc1c(Cl)ccc2nc(Cl)ccc12>>N[C@H]1CCN(c2ccc3c(NC(=O)CC4CCCCC4)c(Cl)ccc3n2)C1",
        "output": "220"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1ccc(Br)cc1C.Cl.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)c1ccc(Br)cc1CBr",
        "output": "545"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.C[Si](C)(C)C=[N+]=[N-].O=C(O)Cc1c[nH]c2ccc(F)cc12.c1ccccc1>>COC(=O)Cc1c[nH]c2ccc(F)cc12",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)COCC#Cc1ccc(C#CCOCC(=O)O)cc1.Cl.[Na+].[OH-]>>O=C(O)COCC#Cc1ccc(C#CCOCC(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NCc1nc(C(F)(F)F)no1.O=C(O)c1cnc(O[C@@H]2CCOC2)c(-c2ccc(Cl)cc2)c1>>O=C(NCc1nc(C(F)(F)F)no1)c1cnc(O[C@@H]2CCOC2)c(-c2ccc(Cl)cc2)c1",
        "output": "674"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.Cc1ncnc(O)c1C(C)C.O=P(Cl)(Cl)Cl>>Cc1ncnc(Cl)c1C(C)C",
        "output": "168"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.COc1cc(NC(=O)C(C)(O)C(F)(F)F)ccc1S(=O)(=O)c1ccncc1.ClCCl>>CC(O)(C(=O)Nc1ccc(S(=O)(=O)c2ccncc2)c(O)c1)C(F)(F)F",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC1CNC1.ClCCl.O=C=Nc1ccc(C(F)(F)F)cc1>>CC(C)(C)OC(=O)NC1CN(C(=O)Nc2ccc(C(F)(F)F)cc2)C1",
        "output": "323"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCc1nc2c(C)cc(Nc3c(N(C)C)c(=O)c3=O)cc2n1Cc1ccc(-c2ccccc2C(=O)OC)cc1.[Na+].[OH-]>>CCc1nc2c(C)cc(Nc3c(N(C)C)c(=O)c3=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)[C@@H]1CC[C@@H](S(=O)(=O)c2ccc(Cl)cc2)CC1.Cl.[Na+].[OH-]>>O=C(O)[C@@H]1CC[C@@H](S(=O)(=O)c2ccc(Cl)cc2)CC1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCOC(=O)N1C[C@@H](O)C[C@H]1C=C(C)C(C)=O.CI.O=[Ag]>>C=CCOC(=O)N1C[C@@H](OC)C[C@H]1C=C(C)C(C)=O",
        "output": "140"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CNc1cc2c(-c3ccc(C(=O)OC)cc3F)cn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2cn1.Cl.O.O.[Li]O>>CNc1cc2c(-c3ccc(C(=O)O)cc3F)cn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2cn1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)Nc1ncccc1N.CCN(C(C)C)C(C)C.ClCCl.O=C(Cl)c1cccc(F)c1F>>CC(C)(C)Nc1ncccc1NC(=O)c1cccc(F)c1F",
        "output": "501"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc2cccnc2c1>>O=S(=O)(Oc1ccc2cccnc2c1)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(C)=O.O=C1c2ccccc2C(=O)N1CCCBr.OCc1cccc(O)c1.[H-].[Na+]>>O=C1c2ccccc2C(=O)N1CCCOc1cccc(CO)c1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC[SiH](CC)CC.COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.Cc1ccccc1.O=C(O)C(F)(F)F.O=Cc1ccc(F)c2ccccc12>>COc1cc(O)c2c(c1C(=O)NCc1ccc(F)c3ccccc13)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C",
        "output": "996"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[B-](F)(F)F.N.O=C(O)c1ccn2c(CO)c(-c3ccc(Cl)cc3)nc2c1>>NC(=O)c1ccn2c(CO)c(-c3ccc(Cl)cc3)nc2c1",
        "output": "358"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)c1ccc2ncc(C(=O)O)c(O)c2c1.O=S(Cl)Cl.c1ccccc1>>CC(C)c1ccc2ncc(C(=O)Cl)c(O)c2c1",
        "output": "188"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O=S(=O)=O.OCc1cc(F)c(F)cc1Br.c1ccncc1>>O=Cc1cc(F)c(F)cc1Br",
        "output": "179"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C(=O)OC(C)(C)C)c4)cc3)nn2CC2CC2)C1.ClCCl.O=C(O)C(F)(F)F>>CC(=O)N1CCc2c(c(Nc3ccc(-c4cn[nH]c4)cc3)nn2CC2CC2)C1",
        "output": "896"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccccc1N(CC(OC)OC)C(=O)C1CCCCC1.Cl.ClCCl.O=C([O-])[O-].Oc1ccc(O)cc1.[Na+].[Na+]>>COc1ccccc1N(CC=O)C(=O)C1CCCCC1",
        "output": "234"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)O[C@H]1CN(Cc2ccccc2)C[C@H]1N=[N+]=[N-].CCOCC.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)[Si](C)(C)O[C@H]1CN(Cc2ccccc2)C[C@H]1N",
        "output": "89"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)S(=O)(=O)c1ccccc1Nc1cc(Cl)ncc1C(F)(F)F.CP(C)(=O)c1ccc(N)c(OC(F)(F)F)c1>>CC(C)S(=O)(=O)c1ccccc1Nc1cc(Nc2ccc(P(C)(C)=O)cc2OC(F)(F)F)ncc1C(F)(F)F",
        "output": "434"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Cl.Cl.N#Cc1ncc(Cl)nc1Cl.N[C@@H]1CCCC(F)(F)[C@@H]1N.O>>N#Cc1ncc(N[C@@H]2CCCC(F)(F)[C@@H]2N)nc1Cl",
        "output": "148"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CC(C2OCCO2)CCN1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CCC(=O)O.ClCCl.F[P-](F)(F)(F)(F)F>>Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CCC(=O)N1CCC(C2OCCO2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)C1=Cc2cc(CC)c(O)cc2OC1C(F)(F)F.Cl.O.O.[Li+].[OH-]>>CCc1cc2c(cc1O)OC(C(F)(F)F)C(C(=O)O)=C2",
        "output": "122"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "NCc1ccncc1.O=C(O)c1ccc(-c2ccncc2)s1>>O=C(NCc1ccncc1)c1ccc(-c2ccncc2)s1",
        "output": "736"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCc1cccc(C2CC3(CCNCC3)C2)c1.Cc1noc(NC(=O)Oc2ccccc2)c1C.Cl>>CCc1cccc(C2CC3(CCN(C(=O)Nc4onc(C)c4C)CC3)C2)c1",
        "output": "525"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)c1cnc(N2CCN(c3nc4ccc(C(F)(F)F)cc4[nH]3)CC2)c(Cl)c1.CO.[BH4-].[Na+]>>CC(O)c1cnc(N2CCN(c3nc4ccc(C(F)(F)F)cc4[nH]3)CC2)c(Cl)c1",
        "output": "449"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)NCC=O.Cc1csc(Cn2c([C@H](N)C(C)C)nc3c(oc4ccc(F)cc43)c2=O)c1.ClCCl.[Na+]>>Cc1csc(Cn2c([C@H](NCCNC(=O)OC(C)(C)C)C(C)C)nc3c(oc4ccc(F)cc43)c2=O)c1",
        "output": "426"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1nn(-c2ccc(CCNC(=O)Oc3ccccc3)cc2)c(C)c1-c1ccccc1.NS(=O)(=O)c1ccncc1>>Cc1nn(-c2ccc(CCNC(=O)NS(=O)(=O)c3ccncc3)cc2)c(C)c1-c1ccccc1",
        "output": "690"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=C(O)C1CC(=O)N(c2ccc(OCc3ccccc3)cc2)C1.O=S(Cl)Cl>>O=C(Cl)C1CC(=O)N(c2ccc(OCc3ccccc3)cc2)C1",
        "output": "53"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(N=[N+]=[N-])c1cnccc1-c1cccc2ccsc12.CCO.NN.O=CO.[Ni]>>CC(N)c1cnccc1-c1cccc2ccsc12",
        "output": "89"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].Cc1cc(C)c(CNC(=O)c2cc(Cl)nc3c2cnn3C(C)C)c(=O)[nH]1.Nc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Cc1cc(C)c(CNC(=O)c2cc(Nc3ccccc3)nc3c2cnn3C(C)C)c(=O)[nH]1",
        "output": "434"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)C1CO1.O=C1c2ccccc2C(=O)N1CCCc1cccc(O)c1>>CC(C)C(O)COc1cccc(CCCN2C(=O)c3ccccc3C2=O)c1",
        "output": "277"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)C(=O)C1.ClCCl.O=C(O)C(F)(F)F>>O=C1CNCCN1Cc1ccccc1",
        "output": "634"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cccc(-c2cccc3cc(CO)sc23)c1.Cl.O.[Na+].[OH-]>>O=C(O)c1cccc(-c2cccc3cc(CO)sc23)c1",
        "output": "5"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cl.ClCCl.c1ccc2c(c1)CCNCC2.c1ccncc1>>CCOC(=O)N1CCc2ccccc2CC1",
        "output": "219"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COc1ccc(CCNC[C@H](C)c2ccccc2)cc1OC.O=C(Cl)c1ccc2c(c1)OCO2>>COc1ccc(CCN(C[C@H](C)c2ccccc2)C(=O)c2ccc3c(c2)OCO3)cc1OC",
        "output": "201"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.OCCc1ccccc1.[Na+]>>COc1cc2nccc(Oc3ccc(NC(=O)OCCc4ccccc4)cc3)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.O.OCCCc1ccccn1>>O=CCCc1ccccn1",
        "output": "142"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1oc2cccc(OCC(O)CNC(C)C)c2c1C.CO.Cl.[Na+].[OH-]>>Cc1c(C(=O)O)oc2cccc(OCC(O)CNC(C)C)c12",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Clc1cccc(N2CCNCC2)c1Cl.Fc1ccc2[nH]cc(CCCCCl)c2c1>>Fc1ccc2[nH]cc(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2c1",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CN1CCN(c2cc(N3CCc4ccc(-c5cnc(N6CCN(C(=O)OC(C)(C)C)CC6)nc5)cc4C3)nc(N)n2)CC1.Cl.O>>CN1CCN(c2cc(N3CCc4ccc(-c5cnc(N6CCNCC6)nc5)cc4C3)nc(N)n2)CC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CC(O)CCC1=O.N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1F>>CN1CC(Oc2ccc(-c3ncnc(Nc4ccc(N5CCN(C6COC6)CC5)cc4)n3)cc2C#N)CCC1=O",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "N#Cc1cc(C=O)ccc1F.Oc1cncc(F)c1>>N#Cc1cc(C=O)ccc1Oc1cncc(F)c1",
        "output": "845"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCC(CC)Oc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1N.CCN(CC)CC.O=C(Cl)CCl>>CCC(CC)Oc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1NC(=O)CCl",
        "output": "422"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(N)c1cnccn1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cc1ccc(-c2cc(C(=O)O)cc(C(=O)N(C)CC(C)C)c2)cc1.Cl.ClCCl.O.On1nnc2ccccc21>>Cc1ccc(-c2cc(C(=O)NC(C)c3cnccn3)cc(C(=O)N(C)CC(C)C)c2)cc1",
        "output": "836"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCCN=C=O.NC1CCCCC1>>CCCCNC(=O)NC1CCCCC1",
        "output": "244"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)CC(=O)c1ccnc(C#N)c1.CC(C)(C)OC(=O)Nc1cc(N2CCSCC2)c(C(F)(F)F)cc1N>>CC(C)(C)OC(=O)Nc1cc(N2CCSCC2)c(C(F)(F)F)cc1NC(=O)CC(=O)c1ccnc(C#N)c1",
        "output": "929"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#CCN1CCN(C)CC1.CCN(CC)CC.ClCCl.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=[N+]([O-])c1ccc(Br)cc1.[Cu]I>>CN1CCN(CC#Cc2ccc([N+](=O)[O-])cc2)CC1",
        "output": "659"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Fc1cc(OCc2cn3cc(Br)cnc3n2)ccn1.Nc1cc(F)ccc1B(O)O>>Nc1cc(F)ccc1-c1cnc2nc(COc3ccnc(F)c3)cn2c1",
        "output": "871"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)COc1c(Br)cc(Br)c(C(N)=O)c1Br.O.[Na+].[OH-]>>NC(=O)c1c(Br)cc(Br)c(OCC(=O)O)c1Br",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.Clc1ccc(N2CCNCC2)cc1Cl>>CC(C)(C)OC(=O)N1CCN(c2ccc(Cl)c(Cl)c2)CC1",
        "output": "694"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1cnc(Nc2cc(Br)nc(C)n2)s1.Cl.O.[Na+].[OH-]>>Cc1nc(Br)cc(Nc2ncc(C(=O)O)s2)n1",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.O=C(NCc1ccc(OC(F)(F)F)cc1)[C@H]1CNCCN1S(=O)(=O)c1ccc(C(F)(F)F)cc1.O=c1[nH]ncc2sc(Cl)nc12>>O=C(NCc1ccc(OC(F)(F)F)cc1)[C@H]1CN(c2nc3c(=O)[nH]ncc3s2)CCN1S(=O)(=O)c1ccc(C(F)(F)F)cc1",
        "output": "558"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.COc1ccc2c(c1C(C)N1CCN(C(=O)OC(C)(C)C)CC1)O/C(=C\\c1n[nH]c3ccccc13)C2=O.Cl.ClCCl>>COc1ccc2c(c1C(C)N1CCNCC1)O/C(=C\\c1n[nH]c3ccccc13)C2=O",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCC(O)(CCC)CNc1cccc(CCCN2C(=O)c3ccccc3C2=O)c1.CCO.NN.O>>CCCC(O)(CCC)CNc1cccc(CCCN)c1",
        "output": "242"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrBr.CC(=O)O.CC(C)(C)OC(=O)N1CCC(n2c(Sc3ccc4c(c3)OCO4)nc3c(N)ncnc32)CC1>>CC(C)(C)OC(=O)N1CCC(n2c(Sc3cc4c(cc3Br)OCO4)nc3c(N)ncnc32)CC1",
        "output": "98"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.Nc1ccc(Cl)nc1Cl.O=C(Cl)c1ccccc1>>O=C(Nc1ccc(Cl)nc1Cl)c1ccccc1",
        "output": "501"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C(CC)(CC)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1.[Na+].[OH-]>>CCC(CC)(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)c1cc2cc(S(C)(=O)=O)cnc2n1Cc1ccc(F)cc1.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[Li+].[Na+]>>CS(=O)(=O)c1cnc2c(c1)cc(CO)n2Cc1ccc(F)cc1",
        "output": "546"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cccc(-c2cccc3c(C)c(Cc4ccc(F)c(Cl)c4)sc23)c1.[Na+].[OH-]>>Cc1c(Cc2ccc(F)c(Cl)c2)sc2c(-c3cccc(C(=O)O)c3)cccc12",
        "output": "5"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(O)C(N)C(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C=O.Cl.ClCCCl.O=C(O)c1nc(-c2ccc(F)cc2)c2ccccn12.On1nnc2cccnc21>>CC(C)(O)C(NC(=O)c1nc(-c2ccc(F)cc2)c2ccccn12)C(F)(F)F",
        "output": "951"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1ccc(C(=O)O)cc1.Cl.NCC(=O)NC(c1ccccc1)c1ccc(Cl)cc1>>CC(=O)c1ccc(C(=O)NCC(=O)NC(c2ccccc2)c2ccc(Cl)cc2)cc1",
        "output": "718"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCOC(=O)c1cc2cccc(OCc3ccccc3)c2[nH]1.CO>>CCCCOC(=O)c1cc2cccc(O)c2[nH]1",
        "output": "264"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.N#Cc1ccc(-c2nc(OC[C@@H]3CCNC3)c3nccn3c2Cl)cc1.[Na+]>>CN1CC[C@@H](COc2nc(-c3ccc(C#N)cc3)c(Cl)n3ccnc23)C1",
        "output": "217"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "NCC1(c2cccnc2)CCCC1.O=C(O)c1cccc(Cl)c1Cl>>O=C(NCC1(c2cccnc2)CCCC1)c1cccc(Cl)c1Cl",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1cccc2c(C)c(S(=O)(=O)Nc3cccc(C(=O)O)c3)sc12>>COC(=O)c1cccc(NS(=O)(=O)c2sc3c(OC)cccc3c2C)c1",
        "output": "33"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCN(CCC)C(=O)C1=Cc2ccc(C(=O)Nc3cccc(CCCCCN4C(=O)c5ccccc5C4=O)c3)cc2N=C(N)C1.CN>>CCCN(CCC)C(=O)C1=Cc2ccc(C(=O)Nc3cccc(CCCCCN)c3)cc2N=C(N)C1",
        "output": "242"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2cnc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)cn2)c(F)c1.O.[Li]O>>O=C(O)c1ccc(-c2cnc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)cn2)c(F)c1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCCCCO.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>C=CCCCCOS(=O)(=O)C(F)(F)F",
        "output": "582"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCc2cc(CCO)ccc2C1.Cc1ccc(S(=O)(=O)Cl)cc1>>Cc1ccc(S(=O)(=O)OCCc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COC(=O)[C@@H]1CC[C@@H](CO)CC1.CS(C)=O.ClC(Cl)Cl.ClCCl.O=C(Cl)C(=O)Cl>>COC(=O)[C@@H]1CC[C@@H](C=O)CC1",
        "output": "142"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#CCOc1ccc(S(=O)(=O)C2(C(=O)OC)CCNCC2)cc1.CCN(CC)CC.CN(C)c1ccccn1.ClC(Cl)Cl.O=C(Cl)c1ccccc1>>CC#CCOc1ccc(S(=O)(=O)C2(C(=O)OC)CCN(C(=O)c3ccccc3)CC2)cc1",
        "output": "201"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCN1.CC#N.[O-][n+]1cccc2cc(OCCBr)ccc21>>[O-][n+]1cccc2cc(OCCN3CCOCC3)ccc21",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCNc1nc(C(F)(F)F)ccc1C(=O)OCC.[Na+].[OH-]>>CCNc1nc(C(F)(F)F)ccc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Clc1ccc(-c2cc(Cl)c3ccccc3n2)cc1.NCC(O)CN>>NCC(O)CNc1cc(-c2ccc(Cl)cc2)nc2ccccc12",
        "output": "78"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOc1cc(N2CCOCC2)c(OCC)cc1N.Cl.Cl.FC(F)(F)c1cc(Cl)nc(-c2cccnc2)n1>>CCOc1cc(N2CCOCC2)c(OCC)cc1Nc1cc(C(F)(F)F)nc(-c2cccnc2)n1",
        "output": "161"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3cc(C)no3)c2)cc1C.ClCCl.O=C(O)C(F)(F)F>>CCN(C)c1cc2c(cc1C)NC(=O)CC(c1cccc(-c3cc(C)no3)c1)=N2",
        "output": "930"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCCCOc1nc(N)c2nc(OC)n(CCCCl)c2n1.CCN(C(C)C)C(C)C.CCN1CCNCC1>>CCCCOc1nc(N)c2nc(OC)n(CCCN3CCN(CC)CC3)c2n1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)CCO.ClC(Cl)(Cl)Cl.[N-]=[N+]=Nc1ccc(C=CC(=O)Cl)cc1>>CN(C)CCOC(=O)C=Cc1ccc(N=[N+]=[N-])cc1",
        "output": "320"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc(F)c(Br)cc1N.Cl.Cl[Sn]Cl.O.O.O=N[O-].[Na+].[Na+].[OH-]>>COc1cc(F)c(Br)cc1NN",
        "output": "109"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC)C(=O)C(c1ccccc1)N1CCN(c2ccc(N)cc2F)CC1.CCO.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(C)(C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccccc1-c1cccnc1.[Na+].[OH-]>>CCN(CC)C(=O)C(c1ccccc1)N1CCN(c2ccc(NC(=O)c3ccccc3-c3cccnc3)cc2F)CC1",
        "output": "50"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCC/C=C\\CCCCCCCC(=O)O.Nc1cccc(N)c1>>CCCCCCCC/C=C\\CCCCCCCC(=O)Nc1cccc(N)c1",
        "output": "365"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C(=O)N1CC=C(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1.CO.[Pd]>>CC(C)C(=O)N1CCC(c2ccc(NC(=O)N3Cc4ccncc4C3)cc2)CC1",
        "output": "806"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCO.CCOC(=O)CC(=O)c1ccc2c(c1)OCO2.COc1n[nH]c(N)c1-c1ccccn1.Cc1ccc(S(=O)(=O)O)cc1>>COc1nn2c(=O)cc(-c3ccc4c(c3)OCO4)[nH]c2c1-c1ccccn1",
        "output": "513"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.COc1ccc(Cl)c(-c2cc(C)c3nc(N)nnc3c2)c1.ClCCl.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C([O-])[O-].O=S(=O)(CCCN1CCCC1)c1ccc(Br)cc1.[Cs+].[Cs+].[Pd].[Pd]>>COc1ccc(Cl)c(-c2cc(C)c3nc(Nc4ccc(S(=O)(=O)CCCN5CCCC5)cc4)nnc3c2)c1",
        "output": "970"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CN1C2CCC1CNC2.Cl.Cl.O=C(CCl)Nc1cc(C(=O)Nc2ccc(-c3ccccc3F)nc2)ccc1OC(F)(F)F.[I-].[K+]>>CN1C2CCC1CN(CC(=O)Nc1cc(C(=O)Nc3ccc(-c4ccccc4F)nc3)ccc1OC(F)(F)F)C2",
        "output": "340"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3ccc(C(F)(F)F)c4CBr)ccc21.COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3ccc(C(F)(F)F)c4CN3CCc4ccsc4C3)ccc21.c1cc2c(s1)CNCC2>>O=C(O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3ccc(C(F)(F)F)c4CN3CCc4ccsc4C3)ccc21",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=C(CN1CCN(C(=O)OC(C)(C)C)CC1)CN(CCC(c1ccccc1)c1ccccc1)C(=O)Nc1ccc(C)cc1.C=C(CN1CCN(C(=O)OC(C)(C)C)CC1)CN(CCC(c1ccccc1)c1ccccc1)C(=O)Nc1cccc(C(=O)OC)c1.ClCCl.O=C(O)C(F)(F)F>>C=C(CN1CCNCC1)CN(CCC(c1ccccc1)c1ccccc1)C(=O)Nc1ccc(C)cc1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.ClCCl.O.O=C([O-])[O-].OB(O)c1ccc(F)cc1.OC1CC2(CCN(c3ccc(Br)cn3)CC2)C1.[Cs+].[Cs+]>>OC1CC2(CCN(c3ccc(-c4ccc(F)cc4)cn3)CC2)C1",
        "output": "833"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.C[Si](C)(C)CCOCN1CCN(C(=O)OCc2ccccc2)CC1=O.[OH-].[OH-].[Pd+2]>>C[Si](C)(C)CCOCN1CCNCC1=O",
        "output": "568"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Cl.CC(C)(C)OC(=O)CCC(N)(CCC(=O)OC(C)(C)C)CCC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl>>CC(=O)NC(CCC(=O)OC(C)(C)C)(CCC(=O)OC(C)(C)C)CCC(=O)OC(C)(C)C",
        "output": "45"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC1CCCCC1)C(=O)O)C(=O)CCCC1CCNCC1.CO.Cl.N[C@@H](CC1CCCCC1)C(=O)O>>COC(=O)[C@@H](N)CC1CCCCC1",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1ccc2ncc(=O)n(CCN3CCC(N)CC3)c2c1.Cc1ccc(C=O)cc1NC(=O)OC(C)(C)C.ClC(Cl)Cl.ClCCl.O=C([O-])O.[Na+].[Na+]>>COc1ccc2ncc(=O)n(CCN3CCC(NCc4ccc(C)c(NC(=O)OC(C)(C)C)c4)CC3)c2c1",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#Cc1cccc(-c2cccc(CNC(=O)OC(C)(C)C)c2)c1.CC(C)NC(C)C.COC(=O)Cc1ccccc1I.Cc1ccccc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COC(=O)Cc1ccccc1C#Cc1cccc(-c2cccc(CNC(=O)OC(C)(C)C)c2)c1",
        "output": "664"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)N1C(=O)N(c2ccc(F)c(N)c2)Cc2cnc(Cl)cc21.CN.[Cu]I>>CNc1cc2c(cn1)CN(c1ccc(F)c(N)c1)C(=O)N2C(C)(C)C",
        "output": "70"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1ccc2nc(N3C4CCC3CC(OCc3c(C5CC5c5ccccc5)noc3C3CC3)C4)sc2c1.CO.O.[Li+].[OH-]>>O=C(O)c1ccc2nc(N3C4CCC3CC(OCc3c(C5CC5c5ccccc5)noc3C3CC3)C4)sc2c1",
        "output": "5"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CNCCO.ClCCl.O=C([O-])O.O=CCn1cc(-c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)cn1.[Na+].[Na+]>>CN(CCO)CCn1cc(-c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)cn1",
        "output": "484"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)NS(=O)(=O)c1cccc(B(O)O)c1.Fc1ccc(-c2cc(C(F)(F)F)nc(-c3cccc(Br)c3)n2)cc1F>>CC(C)(C)NS(=O)(=O)c1cccc(-c2cccc(-c3nc(-c4ccc(F)c(F)c4)cc(C(F)(F)F)n3)c2)c1",
        "output": "837"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.O=CNc1cccc([N+](=O)[O-])c1C=O.[OH-].[OH-].[Pd+2]>>Nc1cccc(NC=O)c1C=O",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)c1cc(Oc2ccc(S(C)(=O)=O)cc2)c2c(c1)OC(CO)C2.CI.[H-].[Na+]>>COCC1Cc2c(Oc3ccc(S(C)(=O)=O)cc3)cc(C(=O)OC(C)(C)C)cc2O1",
        "output": "140"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CCN(CC)CC.CCOC(=O)N1CCc2nc(Cc3ccccc3)nc(Cl)c2CC1.Cn1cc(CN)cn1>>CCOC(=O)N1CCc2nc(Cc3ccccc3)nc(NCc3cnn(C)c3)c2CC1",
        "output": "110"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(c1ccc(-c2ccccc2-c2nnn[nH]2)cc1N)C1CCCC1.Cc1ccc(N=C=O)cc1>>Cc1ccc(NC(=O)Nc2cc(-c3ccccc3-c3nnn[nH]3)ccc2N(C)C2CCCC2)cc1",
        "output": "473"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.COc1cc(Br)c(Oc2ccc([N+](=O)[O-])cc2)c(Br)c1.ClCCl.O=C=O>>O=[N+]([O-])c1ccc(Oc2c(Br)cc(O)cc2Br)cc1",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.COc1cc(CC(C)=O)ccc1OCCCBr.Fc1ccc2c(C3CCNCC3)noc2c1>>COc1cc(CC(C)=O)ccc1OCCCN1CCC(c2noc3cc(F)ccc23)CC1",
        "output": "73"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nc1cnc(Oc2cc3ccccc3cn2)c(Cl)c1.O=S(=O)(Cl)c1ccc(Cl)cc1Cl>>O=S(=O)(Nc1cnc(Oc2cc3ccccc3cn2)c(Cl)c1)c1ccc(Cl)cc1Cl",
        "output": "554"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc(Nc2nn(CC3CC3)c3c2CN(C(C)=O)CC3)c1.O.[K+].[OH-]>>CC(=O)N1CCc2c(c(Nc3cccc(C(=O)O)c3)nn2CC2CC2)C1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.O=C(N1CCOCC1)N1CC(CSC2CCCCC2)CC(c2ccc(C(F)(F)F)cc2)C1.O=C(OO)c1cccc(Cl)c1>>O=C(N1CCOCC1)N1CC(CS(=O)C2CCCCC2)CC(c2ccc(C(F)(F)F)cc2)C1",
        "output": "13"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1c(-c2c(CO)n(C)c(=O)c3sc4c(c23)CCCC4)ccc2c1CCCO2.ClC(Cl)Cl.[Mn+4].[O-2].[O-2]>>Cc1c(-c2c(C=O)n(C)c(=O)c3sc4c(c23)CCCC4)ccc2c1CCCO2",
        "output": "263"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)CCCCCC/C(=N\\OCc1ccc(OCc2nc(-c3ccccc3)oc2C)cc1)c1ccc(Cl)cc1.Cl.O.O.[Li+].[OH-]>>Cc1oc(-c2ccccc2)nc1COc1ccc(CO/N=C(\\CCCCCCC(=O)O)c2ccc(Cl)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1ccc([C@H](C)NC(=O)c2cc(Cl)cnc2Oc2cccc(F)c2)cc1.Cl.[Na+].[OH-]>>C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC1(O)CCNC1.CCN(CC)CC.CO.Fc1c(Cl)nc(Cl)nc1Cl>>CC1(O)CCN(c2nc(Cl)nc(Cl)c2F)C1",
        "output": "296"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.CCOC(CCCN)OCC.O=C([O-])[O-].[K+].[K+].c1ccccc1>>CCOC(CCCNC(C)=O)OCC",
        "output": "339"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.OCc1cc(Br)ccc1Cl.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCc1cc(Br)ccc1Cl",
        "output": "193"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C=CCc1cc(C(F)(F)F)nn1CC(=O)OC.CO.O.O.[Li+].[OH-]>>C=CCc1cc(C(F)(F)F)nn1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)CCCCCCCn1cc(-c2ccccc2)n(-c2ccc(F)cc2)c1=O.[Na+].[OH-]>>O=C(O)CCCCCCCn1cc(-c2ccccc2)n(-c2ccc(F)cc2)c1=O",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.CO.C[C@H](N)c1nc2ccc(F)cc2n1-c1cncc(F)c1.Cc1nc(N)nc(Cl)c1C#N>>Cc1nc(N)nc(N[C@@H](C)c2nc3ccc(F)cc3n2-c2cncc(F)c2)c1C#N",
        "output": "110"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.COc1ccc(NC(=O)Nc2ccc(F)cc2F)cc1-c1c(Cl)cnn1C.ClCCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>Cn1ncc(Cl)c1-c1cc(NC(=O)Nc2ccc(F)cc2F)ccc1O",
        "output": "402"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1C[C@H](NC(=O)c2ccc(Cl)s2)C[C@H]1CO.CCN(CC)CC.CCOC(C)=O.CS(C)=O.ClCCl>>CC(C)(C)OC(=O)N1C[C@H](NC(=O)c2ccc(Cl)s2)C[C@H]1C=O",
        "output": "610"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCOC(=O)CBr.O=C([O-])[O-].Oc1cccc2c1CCCC2.[K+].[K+]>>CCOC(=O)COc1cccc2c1CCCC2",
        "output": "123"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.CO.COc1ccc2[nH]c3c(c2c1)CNCC3.ClC(Cl)Cl.O=C(n1ccnc1)n1ccnc1>>COc1ccc2[nH]c3c(c2c1)CN(C(=O)NCCCCN1CCN(c2cc(C(F)(F)F)nc(C(C)(C)C)n2)CC1)CC3",
        "output": "734"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)c1cc(C2CC2)cnc1Nc1ccc2[nH]ccc2c1.O.O=C1CCC(=O)N1Br>>COC(=O)c1cc(C2CC2)cnc1Nc1ccc2[nH]cc(Br)c2c1",
        "output": "796"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CO.O=[N+]([O-])c1ccc2c(c1)-c1nc(Cc3c[nH]cn3)sc1CC2.[H][H].[Ni]>>Nc1ccc2c(c1)-c1nc(Cc3c[nH]cn3)sc1CC2",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[O-].Cc1ccccc1.Clc1ccccc1.Nc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>c1ccc(Nc2ccccc2)cc1",
        "output": "510"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(Oc1cc(-c2nn(C)c(OC(F)F)c2Cl)c(Cl)cc1Cl)C(=O)Cl.CCOC(C)=O.CNC.c1cn[nH]c1>>CC(Oc1cc(-c2nn(C)c(OC(F)F)c2Cl)c(Cl)cc1Cl)C(=O)N(C)C",
        "output": "125"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.C[C@H]1CNCCc2ccc(Cl)c(Cl)c21.[Na+].[Na+].[OH-]>>C[C@H]1CN(C)CCc2ccc(Cl)c(Cl)c21",
        "output": "217"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1Cc2nc3c(Br)cccc3c(N)c2C1=O.COc1cccc(F)c1B(O)O>>COc1cccc(F)c1-c1cccc2c(N)c3c(nc12)CN(C)C3=O",
        "output": "833"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C(Cl)OCCCl.OC(CCl)COc1ccccc1>>O=C(OCCCl)OC(CCl)COc1ccccc1",
        "output": "144"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNOC.C[C@@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.F[P-](F)(F)(F)(F)F>>CON(C)C(=O)[C@@H](C)NC(=O)OC(C)(C)C",
        "output": "54"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CSc1ccc(C(=O)c2sc(=O)[nH]c2C)cc1.O.OO>>Cc1[nH]c(=O)sc1C(=O)c1ccc(S(C)=O)cc1",
        "output": "199"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.Cl.Cl[Ni]Cl.N#Cc1ccc(C2CCOCC2)cc1.[BH4-].[Na+]>>NCc1ccc(C2CCOCC2)cc1",
        "output": "175"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCC(C(=O)OC)c1c(C)nc2c(Cl)c(C(C)(C)C)nn2c1-c1ccc(C)cc1.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc2c(Cl)c(C(C)(C)C)nn2c1-c1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(c1ccccc1)c1ccc(OC[C@H]2CCC[C@H]2N)cc1.CCN(CC)CC.CCOC(=O)Cl.CCOCC.Cl>>CCOC(=O)N[C@@H]1CCC[C@@H]1COc1ccc(C(C)(C)c2ccccc2)cc1",
        "output": "94"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CSc1c(CC(=O)OC(C)(C)C)cc(C)c2c1[nH]c1ccccc12.ClCc1ccc(Cl)cc1>>CSc1c(CC(=O)OC(C)(C)C)cc(C)c2c3ccccc3n(Cc3ccc(Cl)cc3)c12",
        "output": "556"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.CC(Sc1nc(N)cc(Cl)n1)c1cc2ccccc2cn1.CO>>CC(Sc1nc(N)c(Br)c(Cl)n1)c1cc2ccccc2cn1",
        "output": "381"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)CNCCOc1ccc(CCCCNC(=O)OC(C)(C)C)cc1.Cl.[Li+].[OH-]>>CC(C)(C)OC(=O)NCCCCc1ccc(OCCNCC(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1cc(-c2ccc(C)cc2)n(-c2ccc(F)cc2)n1.CO.[K+].[OH-]>>Cc1ccc(-c2cc(C(=O)O)nn2-c2ccc(F)cc2)cc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.C[Si](C)(C)C#Cc1cc(F)c(F)cc1F.O=C([O-])[O-].[K+].[K+]>>C#Cc1cc(F)c(F)cc1F",
        "output": "337"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.N#Cc1c[nH]c2ccc(CCN=[N+]=[N-])cc12.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1c[nH]c2ccc(CCN)cc12",
        "output": "89"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#C[C@@]1(O)[C@@H](CO[Si](C)(C)C(C)(C)C)O[C@@H](n2ccc(N)nc2=O)[C@@H]1O.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)CC(=O)O.Cl>>C#C[C@@]1(O)[C@@H](CO[Si](C)(C)C(C)(C)C)O[C@@H](n2ccc(NC(=O)CN(C)C)nc2=O)[C@@H]1O",
        "output": "368"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccccc1Cc1c(C)n(Cc2ccc(Br)cc2)c2ccc(OC)cc12.[Na+].[OH-]>>COc1ccc2c(c1)c(Cc1ccccc1C(=O)O)c(C)n2Cc1ccc(Br)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CC[C@@H](N)c1cnc(OC)c(Cl)c1.CN(C)C=O.C[C@H]1CCCN1C(=O)c1cc(C(=O)O)c2n1CCOC2.Cl.Cl.On1nnc2ccccc21>>CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2c1COCC2)c1cnc(OC)c(Cl)c1",
        "output": "674"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.O=C(N1CC[C@@H](c2ccncc2)C1)C1(c2ccc(Cl)cc2)CC1.O=C(OO)c1cccc(Cl)c1>>O=C(N1CC[C@@H](c2cc[n+]([O-])cc2)C1)C1(c2ccc(Cl)cc2)CC1",
        "output": "262"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)CC1Cc2ccc(OCCCCNC(=N)N)cc2NC1=O.COC(=O)Cc1cc2ccc(OCCNC(=N)N)cc2n(Cc2ccccc2)c1=O.O=C(O)C(F)(F)F>>N=C(N)NCCOc1ccc2cc(CC(=O)O)c(=O)n(Cc3ccccc3)c2c1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CNC1.CS(C)=O.Cl.O.O=C([O-])[O-].O=[N+]([O-])c1cccc(F)c1.[K+].[K+]>>O=[N+]([O-])c1cccc(N2CCC2)c1",
        "output": "26"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC1(O)CCNCC1.CS(=O)(=O)OCCc1ccc(CCc2ccc(OCc3ccccc3)nn2)cc1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CC1(O)CCN(CCc2ccc(CCc3ccc(OCc4ccccc4)nn3)cc2)CC1",
        "output": "496"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.COc1cc(C(=O)O)ccc1O.O=[N+]([O-])O>>COc1cc(C(=O)O)cc([N+](=O)[O-])c1O",
        "output": "21"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)O.CC(C)(C)[O-].CCOC(C)=O.CI.C[C@]12CCC(=O)N[C@@H]1CCc1cc(Sc3ccccc3)ccc12.[K+]>>CN1C(=O)CC[C@]2(C)c3ccc(Sc4ccccc4)cc3CC[C@@H]12",
        "output": "83"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.CSCc1cccc2c(C(CCC#N)c3ccc(F)cc3C)c[nH]c12.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cc1cc(F)ccc1C(CCC#N)c1c[nH]c2c(CS(C)=O)cccc12",
        "output": "13"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.CC(C)=O.COc1ccc(F)cc1C(C)(C)CC(O)(CNc1cc(C)cc2c1cnn2-c1cccc(C(=O)N(C)CC(N)=O)c1)C(F)(F)F.ClCCl.O=C=O>>Cc1cc(NCC(O)(CC(C)(C)c2cc(F)ccc2O)C(F)(F)F)c2cnn(-c3cccc(C(=O)N(C)CC(N)=O)c3)c2c1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCC1CCCCO1.CN(C)C=O.O=C([O-])[O-].Oc1cccc(Br)c1.[K+].[K+]>>Brc1cccc(OCC2CCCCO2)c1",
        "output": "18"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.Cl[Sn]Cl.O=[N+]([O-])c1ccc(-n2nc3ccc(Cl)cc3n2)cc1>>Nc1ccc(-n2nc3ccc(Cl)cc3n2)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(=O)[C@@H](N)CC(C)C.CCOC(C)=O.CN(C)C=O.Cc1nc(C)c(-c2ccc(-c3ccc(CC(=O)O)cc3Cl)cc2)nc1C(N)=O.Cl.Cl.On1nnc2ccccc21>>CCOC(=O)[C@H](CC(C)C)NC(=O)Cc1ccc(-c2ccc(-c3nc(C(N)=O)c(C)nc3C)cc2)c(Cl)c1",
        "output": "107"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.COC(=O)c1cn(-c2ccc3c(c2)n(C)c(=O)n3C)c(=O)n(C2CCCc3c(Cl)cccc32)c1=O.Cl>>Cn1c(=O)n(C)c2cc(-n3cc(C(=O)O)c(=O)n(C4CCCc5c(Cl)cccc54)c3=O)ccc21",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.CN1CCC(n2cc(N)cn2)CC1.COCCOc1ccc(Nc2nc(Cl)ncc2[N+](=O)[O-])cc1>>COCCOc1ccc(Nc2nc(Nc3cnn(C4CCN(C)CC4)c3)ncc2[N+](=O)[O-])cc1",
        "output": "992"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C[C@@H]1CCc2cc(O)ccc21.CN(C)C(=O)/N=N/C(=O)N(C)C.Cc1ccc(-c2nc(CCO)c(C)o2)cc1.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)C[C@@H]1CCc2cc(OCCc3nc(-c4ccc(C)cc4)oc3C)ccc21",
        "output": "478"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCCO.CCOC(C)=O.Cc1nc(NCCCc2cccc(O)c2)nc(C)c1C(=O)N[C@@H](CNC(=O)c1cccs1)C(=O)O.O=S(Cl)Cl>>CCCOC(=O)[C@H](CNC(=O)c1cccs1)NC(=O)c1c(C)nc(NCCCc2cccc(O)c2)nc1C",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC1CCCN1.CN1CCc2sc(-c3ccc(OCCCCl)cc3)nc2C1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CC1CCCN1CCCOc1ccc(-c2nc3c(s2)CCN(C)C3)cc1",
        "output": "138"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCC.COc1c(C)cc(F)cc1C=O.C[Mg]Br>>COc1c(C)cc(F)cc1C(C)O",
        "output": "787"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)CC1(N)CS(=O)(=O)C1.CO.N>>NC(=O)CC1(N)CS(=O)(=O)C1",
        "output": "163"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.COc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(OS(=O)(=O)C(F)(F)F)ccc2c1.Cc1ccccc1.ClCCl.Cl[Pd]Cl.O.O=C([O-])[O-].OCc1ccc(B(O)O)cc1.[Cl-].[Fe+2].[K+].[K+].[Li+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(-c3ccc(CO)cc3)ccc2c1",
        "output": "825"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1c2n(c3c(Br)cc(Cl)cc13)CCNC2=O.OB(O)c1ccc(Cl)c(F)c1>>Cc1c2n(c3c(-c4ccc(Cl)c(F)c4)cc(Cl)cc13)CCNC2=O",
        "output": "833"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(CC)CC.CCOP(=O)(C#N)OCC.CN(C)C=O.ClCCl.NCCN1CCOCC1.O=C(O)c1c[nH]c(-c2n[nH]c3ncccc23)c1>>O=C(NCCN1CCOCC1)c1c[nH]c(-c2n[nH]c3ncccc23)c1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCCCCC(=O)O.Nc1cccc(C(=O)O)c1>>CC(C)(C)OC(=O)NCCCCC(=O)Nc1cccc(C(=O)O)c1",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCO.CS(=O)(=O)OCCC#Cc1ccc2c(-c3ccc(Cl)cc3)nsc2c1>>CS(=O)(=O)OCCCCc1ccc2c(-c3ccc(Cl)cc3)nsc2c1",
        "output": "717"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CCNC3)cc1.COC(=O)Cl>>CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CCN(C(=O)OC)C3)cc1",
        "output": "219"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCc1ccc(O)c(O)c1.O.[Na+].[OH-]>>CC(C)(C)OC(=O)NCCc1ccc(O)c(O)c1",
        "output": "631"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)C(F)(F)c1ccc(-c2ccc(Br)cc2)cc1.CO.[BH4-].[Na+]>>OCC(F)(F)c1ccc(-c2ccc(Br)cc2)cc1",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(N=[N+]=[N-])c3ccccc32)cc1.[H][H].[Pd]>>Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(N)c3ccccc32)cc1",
        "output": "562"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cc1ccc(S(=O)(=O)n2cncc2CC(=O)CF)cc1.Cl.[BH4-].[Na+]>>Cc1ccc(S(=O)(=O)n2cncc2CC(O)CF)cc1",
        "output": "91"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COCCBr.O=C([O-])[O-].O=[N+]([O-])c1cc(O)c(F)cc1Br.[K+].[K+]>>COCCOc1cc([N+](=O)[O-])c(Br)cc1F",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C(=O)OC(C)(C)C)c1cc(Sc2ccccn2)ccc1[N+](=O)[O-].CO.[Pd]>>CN(C(=O)OC(C)(C)C)c1cc(Sc2ccccn2)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C(N)=NO.Cc1ccc(C2CC(C(=O)O)CN(C(=O)N3CCC(O)CC3)C2)cc1C>>Cc1ccc(C2CC(c3nc(C(C)C)no3)CN(C(=O)N3CCC(O)CC3)C2)cc1C",
        "output": "728"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(O)c1.CCOC(=O)C(C)(C)Br.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C(C)(C)Oc1cccc(NC(=O)OC(C)(C)C)c1",
        "output": "305"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(=O)O.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCCCC2c2ccoc3cccc2-3)CC1>>CCC(=O)N[C@@H]1CC[C@@H](CCN2CCCCC2c2ccoc3cccc2-3)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)Cc1ccc(SC)cc1.O.O=S([O-])OO.[K+]>>COC(=O)Cc1ccc(S(C)(=O)=O)cc1",
        "output": "730"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OCc1c(-c2cc(Nc3nc4c(s3)CN(C(=O)OC(C)(C)C)CC4)c(=O)n(C)c2)ccnc1N1CCn2c(cc3c2CC(C)(C)C3)C1=O.CCOC(C)=O.Cl>>CC(=O)OCc1c(-c2cc(Nc3nc4c(s3)CNCC4)c(=O)n(C)c2)ccnc1N1CCn2c(cc3c2CC(C)(C)C3)C1=O",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN1CCC(N(C)C(=O)Nc2cc(Oc3ccc([N+](=O)[O-])cc3F)ccn2)CC1.CO.[Pd]>>CN1CCC(N(C)C(=O)Nc2cc(Oc3ccc(N)cc3F)ccn2)CC1",
        "output": "335"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1ccc(N)c([N+](=O)[O-])c1C.O.O=C[O-].[Fe].[NH4+]>>COC(=O)c1ccc(N)c(N)c1C",
        "output": "481"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)OCC(CCc2ccccc2)([N+](=O)[O-])CO1.CCCCCCCC(=O)Cl>>CCCCCCCC(=O)c1ccc(CCC2([N+](=O)[O-])COC(C)(C)OC2)cc1",
        "output": "31"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COC(=O)c1nn(CCBr)c(C(=O)OC)c1OCc1ccccc1.[N-]=[N+]=[N-].[Na+]>>COC(=O)c1nn(CCN=[N+]=[N-])c(C(=O)OC)c1OCc1ccccc1",
        "output": "622"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCOCC1.Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)Cl)cc2s1.ClC(Cl)Cl.NCc1ccc(F)cc1>>Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)NCc3ccc(F)cc3)cc2s1",
        "output": "530"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.CS(=O)(=O)c1ccc(O)cn1.Cc1cc(F)ccc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>Cc1cc(Oc2ccc(S(C)(=O)=O)nc2)ccc1[N+](=O)[O-]",
        "output": "845"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOc1ccc(C(=O)Cl)cc1.CNCCNC(=O)c1cn(-c2ccccc2)nc1C(F)(F)F.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CCOc1ccc(C(=O)N(C)CCNC(=O)c2cn(-c3ccccc3)nc2C(F)(F)F)cc1",
        "output": "201"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.CCN(CC)CC.Cl.Cn1cc(-c2cc3nccn3c(-c3cnn(C4(CC#N)CNC4)c3)n2)cn1.O>>CC(=O)N1CC(CC#N)(n2cc(-c3nc(-c4cnn(C)c4)cc4nccn34)cn2)C1",
        "output": "369"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCC2(CC2)CN1.CC1(C)c2sc(Br)cc2C(=O)N1CCOS(C)(=O)=O.CCOC(C)=O.CN(C)C=O>>CC1(C)c2sc(Br)cc2C(=O)N1CCN1CCOCC2(CC2)C1",
        "output": "496"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.Nc1cc(Cl)nc(C(F)(F)F)n1>>CC(C)(C)OC(=O)Nc1cc(Cl)nc(C(F)(F)F)n1",
        "output": "849"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCC=Cc1c(C(C)C)nc(C(C)C)c(C(=O)OCC)c1-c1cccc(OCc2ccccc2)c1.CCCCCC.CCOC(C)=O>>CCCC=Cc1c(C(C)C)nc(C(C)C)c(CO)c1-c1cccc(OCc2ccccc2)c1",
        "output": "383"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)C(=O)OCC1CNCCN1.CCN(CC)CC.CO.COc1cc(C(=O)Cl)cc(OC)c1OC.Cl.Cl.ClCCl.ClCCl.[NH4+].[OH-]>>CCN(CC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1",
        "output": "201"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(N)nc1.CCO.O=C(CBr)c1ccc(Br)cc1>>CC(C)(C)OC(=O)Nc1ccc2nc(-c3ccc(Br)cc3)cn2c1",
        "output": "508"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(N)c([N+](=O)[O-])c(OC)c1.COc1ccc(Cl)c(N)c1N>>COc1cc(N)c(N)c(OC)c1",
        "output": "202"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.C[C@@H](NC(=O)OC(C)(C)C)[C@@H]1CC[C@H](O)CC1.ClCCl>>C[C@@H](NC(=O)OC(C)(C)C)[C@H]1CC[C@@H](OS(C)(=O)=O)CC1",
        "output": "0"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CC[C@@H]1NCCN([C@@H](Cc2ccc3ccccc3c2)C(=O)OC)C1=O.CC(C)(C)OC(=O)N[C@H](Cc1ccc(F)cc1)C(=O)O.CCN(CC)CC.ClCCl>>C=CC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)OC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)OC(C)(C)C",
        "output": "297"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CC1Cc2ccc(OC)cc2Cc2cc(F)ccc21.CCOC(=O)CC1Cc2ccc(OC)cc2Cc2ccccc21.CO.ClCCl>>CCOC(=O)CC1Cc2ccc(O)cc2Cc2cc(F)ccc21",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COc1cc(C=O)ccc1OCCN1CCNC1=O.NO>>COc1cc(C=NO)ccc1OCCN1CCNC1=O",
        "output": "30"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1CN(C(=O)OC(C)(C)C)Cc2scc(-c3cccc(F)c3)c2O1.CCOC(C)=O.Cl>>CC1CNCc2scc(-c3cccc(F)c3)c2O1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Oc1ccc(C#CC(O)(CC2(c3cc(C(F)(F)F)ccc3F)CC2)C(=O)Nc2ccc3c(c2)COC3=O)cc1.CCOC(C)=O.CO.O=C([O-])O.[Na+]>>O=C1OCc2cc(NC(=O)C(O)(C#Cc3ccc(O)cc3)CC3(c4cc(C(F)(F)F)ccc4F)CC3)ccc21",
        "output": "22"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCCC1C(=O)Nc1ccc(-c2ccccc2S(C)(=O)=O)cc1F.ClC(Cl)Cl.ClCCl.O=C(O)C(F)(F)F>>CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)C2CCCN2)c(F)c1",
        "output": "634"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1ccc(F)c2occc12.CO.O.[Na+].[OH-]>>O=C(O)c1ccc(F)c2occc12",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1COc1cc([N+](=O)[O-])cc(C(F)(F)F)c1.CCO.[Pd]>>CC(C)(C)OC(=O)N1CCC[C@H]1COc1cc(N)cc(C(F)(F)F)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CCOP(=O)(OCC)C(C)(O)CSC(C)(C)C.ClCCl.O=S(=O)(O)O>>CCOP(=O)(OCC)C(C)(CSC(C)(C)C)OC(C)=O",
        "output": "254"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br.CC(=O)O.COc1ccc(-n2cc(C)cn2)cc1F>>Cc1cnn(-c2ccc(O)c(F)c2)c1",
        "output": "402"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Clc1nc(N2CCOCC2)nc(N2CCOCC2)n1.Nc1nc2ccccc2[nH]1.O.[H-].[Na+]>>Nc1nc2ccccc2n1-c1nc(N2CCOCC2)nc(N2CCOCC2)n1",
        "output": "916"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.CNc1ccc(C(OC)OC)nc1.CNc1ccc(C=O)nc1.C[C@H]1CNCCN1C(=O)OC(C)(C)C.ClCCCl.ClCCl.[Na+]>>CNc1ccc(CN2CCN(C(=O)OC(C)(C)C)[C@@H](C)C2)nc1",
        "output": "829"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC[S-].CN(C)C=O.COc1ccc2ncnc(Nc3cccc(Br)c3)c2c1.[Na+].c1ccc2ncncc2c1>>Oc1ccc2ncnc(Nc3cccc(Br)c3)c2c1",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)n1cc(-c2ncc(N)nc2-c2ccccc2)ccc1=O.CN(C)C=O.ClCCl.O.O=C1CCC(=O)N1Br>>CC(C)n1cc(-c2nc(Br)c(N)nc2-c2ccccc2)ccc1=O",
        "output": "665"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)OB(c2ccc(N)nc2)OC1(C)C.O=C(CBr)c1ccc(F)cc1F>>CC1(C)OB(c2ccc3nc(-c4ccc(F)cc4F)cn3c2)OC1(C)C",
        "output": "508"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(CCCCOc1ccc(OCCCCCn2ccnc2)cc1)C(N)=O.ClC(Cl)Cl.ClCCl.ClP(Cl)(Cl)(Cl)Cl.c1ccncc1>>CC(C)(C#N)CCCCOc1ccc(OCCCCCn2ccnc2)cc1",
        "output": "172"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.Cc1nc(CC2CCN(c3ccc(-c4ccc(CO)cc4)cc3)CC2)nc(C(=O)OC(C)(C)C)c1OCc1ccccc1.Cl.[Na+].[OH-]>>Cc1nc(CC2CCN(c3ccc(-c4ccc(CO)cc4)cc3)CC2)nc(C(=O)O)c1OCc1ccccc1",
        "output": "569"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.ClCCl.N#Cc1c[nH]c(-c2nc([C@H]3CCCNC3)no2)c1.O=C(O)c1ccncc1F.On1nnc2cccnc21>>N#Cc1c[nH]c(-c2nc([C@H]3CCCN(C(=O)c4ccncc4F)C3)no2)c1",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.Cl[Pd]Cl.O=C(O)c1ccc(F)c(Br)n1.OB(O)c1ccccc1F.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=C(O)c1ccc(F)c(-c2ccccc2F)n1",
        "output": "869"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)[Si](Cl)(C(C)C)C(C)C.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.Oc1cc(Br)ccc1Cl>>CC(C)[Si](Oc1cc(Br)ccc1Cl)(C(C)C)C(C)C",
        "output": "746"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CN(C)c1ccncc1.COc1cc(OC)cc(C(O)[C@H]2[C@](C)(O)CC[C@H]3C(C)(C)CCC[C@@]32C)c1.ClCCl>>COc1cc(OC)cc(C(OC(C)=O)[C@H]2[C@](C)(O)CC[C@H]3C(C)(C)CCC[C@@]32C)c1",
        "output": "254"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1nc2cccc(COc3ccc(OCc4ccc5ccccc5n4)cc3)c2o1.O.O=C([O-])O.[Na+]>>O=C(O)c1nc2cccc(COc3ccc(OCc4ccc5ccccc5n4)cc3)c2o1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(N)(C#N)Cc1ccc(F)cc1.CCO.CCOCC.Cl.O=[Pt]=O>>CC(N)(CN)Cc1ccc(F)cc1",
        "output": "246"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1nc(N)cc(O)n1.O=P(Cl)(Cl)Cl>>Cc1nc(N)cc(Cl)n1",
        "output": "25"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(N)C(F)(F)F.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(C(C)C)C(C)C.CCOC(C)=O.Cc1nc(C(=O)O)ccc1Br.O>>Cc1nc(C(=O)NC(C)C(F)(F)F)ccc1Br",
        "output": "137"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)NS(=O)(=O)c1cccc(CO)c1.CCOC(C)=O.ClCCl.O=C([O-])O.[Na+]>>CC(C)(C)NS(=O)(=O)c1cccc(C=O)c1",
        "output": "179"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCOC(=O)c1c(-c2ccc(F)cc2)oc2cc(NS(C)(=O)=O)c(Br)cc12.O.O.[Li]O>>CS(=O)(=O)Nc1cc2oc(-c3ccc(F)cc3)c(C(=O)O)c2cc1Br",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1ccc(-c2nc3c(C(=O)O)cc(Cl)cc3o2)s1.Cl.Cl.Cl.ClCCl.N[C@@H]1CN2CCC1CC2.On1nnc2ccccc21>>Cc1ccc(-c2nc3c(C(=O)N[C@@H]4CN5CCC4CC5)cc(Cl)cc3o2)s1",
        "output": "674"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.Cc1cccc2c1CCC2=O.O.[BH4-].[Na+]>>Cc1cccc2c1CCC2O",
        "output": "24"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CO.ClCCCl.N[C@H]1CC[C@@H](C(c2ccccc2)c2ccccc2)OC1.O=Cc1ccc(Br)cc1.[BH3-]C#N.[Na+]>>Brc1ccc(CN[C@H]2CC[C@@H](C(c3ccccc3)c3ccccc3)OC2)cc1",
        "output": "468"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCc1ccccc1.COC(=O)c1ccc(O)cc1>>COC(=O)c1ccc(OCCCc2ccccc2)cc1",
        "output": "385"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCn1c(CCCCCNC(=O)OCc2ccccc2)nc2ccc(C#N)cc21.CCO.[C].[Pd]>>CCCn1c(CCCCCN)nc2ccc(C#N)cc21",
        "output": "574"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Cc1ccc(-c2cc(C(N)=O)c3[nH]cc(C4CCN(C(=O)OC(C)(C)C)CC4)c3c2)cc1.Cl.NC(=O)c1cc(-c2cccs2)cc2c(C3CCNCC3)c[nH]c12>>Cc1ccc(-c2cc(C(N)=O)c3[nH]cc(C4CCNCC4)c3c2)cc1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCN1.CCN(CC)CC.CCO.Cc1ccc(C(=O)N2CCC(c3ccc(C#N)cc3)CC2)cc1NS(=O)(=O)c1ccc(Cl)nc1>>Cc1ccc(C(=O)N2CCC(c3ccc(C#N)cc3)CC2)cc1NS(=O)(=O)c1ccc(N2CCOCC2)nc1",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CCOC(=O)NC(CC(=O)OCC)c1cccc([N+](=O)[O-])c1.CCO.Cl[Sn]Cl.[Na+].[OH-]>>C=CCOC(=O)NC(CC(=O)OCC)c1cccc(N)c1",
        "output": "71"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)/C=C(\\C)C1CCN(C(=O)OC(C)(C)C)CC1.CO.O.[Na+].[OH-]>>C/C(=C\\C(=O)O)C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "122"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)C4CCN(C5CCN(C(=O)OC(C)(C)C)C5)C4)c3Cl)cccc2n1Cc1ccccn1.C[Si](C)(C)OS(=O)(=O)C(F)(F)F.ClCCl>>COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)C4CCN(C5CCNC5)C4)c3Cl)cccc2n1Cc1ccccn1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CNCCNCCN1.CCN(C(C)C)C(C)C.CCOCC.COCCO.Cl.Cl.Cl.Nc1nc(Cl)c2c(n1)-c1ccccc1CCC2>>Nc1nc2c(c(N3CCNCCNCC3)n1)CCCc1ccccc1-2",
        "output": "162"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.O.O=c1[nH]nc(-c2ccccc2)c(-c2ccccc2)c1-c1ccccc1.OCCCl.[Na+].[OH-]>>O=c1c(-c2ccccc2)c(-c2ccccc2)c(-c2ccccc2)nn1CCO",
        "output": "604"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)O.CCOC(=O)CCc1cc2cc(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)ccc2n1C.Cl.O.[Na+].[OH-]>>CC(C)Oc1ccc(-c2nc(-c3ccc4c(c3)cc(CCC(=O)O)n4C)no2)cc1Cl",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.COc1cc(C)cc(C#N)c1.ClB(Cl)Cl.ClCCl.[I-]>>Cc1cc(O)cc(C#N)c1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCOC(C)=O.CSCC[C@@H](NC(=O)OC(C)(C)C)C(=O)O.Oc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl>>CSCC[C@@H](NC(=O)OC(C)(C)C)C(=O)Oc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl",
        "output": "108"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CN)c1.O=C(O)c1cccc(Cl)c1>>Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2cccc(Cl)c2)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COc1ccc(C(=O)c2c(Cc3ccccc3)oc(C)c2C)cc1C1CCCC1.ClCCl.ClCCl>>Cc1oc(Cc2ccccc2)c(C(=O)c2ccc(O)c(C3CCCC3)c2)c1C",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CNC[C@@H](O)c1cccnc1.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2sc(CCl)cc21.O>>CN(Cc1cc2c(s1)c(=O)c(C(=O)NCc1ccc(Cl)cc1)cn2C)C[C@@H](O)c1cccnc1",
        "output": "639"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCc1ccc(-c2ccc(C(=O)O)cc2)cc1.CN1CCN(c2cccc3c2C[C@H](N)CC3)CC1.ClCCl.O=S(Cl)Cl>>CCc1ccc(-c2ccc(C(=O)N[C@@H]3CCc4cccc(N5CCN(C)CC5)c4C3)cc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.Nc1ccc([N+](=O)[O-])cc1O.O=C(Cl)C(F)(F)C(F)Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(Nc1ccc([N+](=O)[O-])cc1O)C(F)(F)C(F)Cl",
        "output": "9"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cn(CC2CCNC2)c2ccc(I)cc2c1=O.CO.Cl.Cl.O.O.O=CCN1CCOCC1.[BH3-]C#N.[Na+]>>CCOC(=O)c1cn(CC2CCN(CCN3CCOCC3)C2)c2ccc(I)cc2c1=O",
        "output": "484"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.N#Cc1cccc(Br)c1.O.O.OB(O)c1ccccc1.[Cl-].[Na+]>>N#Cc1cccc(-c2ccccc2)c1",
        "output": "837"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.COc1cccc(CNC(=O)c2cccc([N+](=O)[O-])c2)c1.O.O=C([O-])O.[Na+]>>COc1cccc(CNC(=O)c2cccc(N)c2)c1",
        "output": "489"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CNCc1cccs1.F[P-](F)(F)(F)(F)F.O=C(O)c1nc2c(C(F)(F)F)cc(-c3ccoc3)cn2c1Cl>>CN(Cc1cccs1)C(=O)c1nc2c(C(F)(F)F)cc(-c3ccoc3)cn2c1Cl",
        "output": "729"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O.O.[Na+].[OH-]>>CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CN1CCCC1=O.COC(=O)Cl.Nc1ccc(C(=O)O)cc1NC(=O)NC(=O)c1ccc(F)cc1Cl.O.c1ccncc1>>COC(=O)Nc1ccc(C(=O)O)cc1NC(=O)NC(=O)c1ccc(F)cc1Cl",
        "output": "102"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cc1cccc(Oc2ccc(Cl)c(Cl)c2)c1N.O.[Na+].[OH-].c1ccccc1>>Nc1c(CC(=O)O)cccc1Oc1ccc(Cl)c(Cl)c1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.CON.COc1ccc2c(c1)CCCC2=O.Cl>>CON=C1CCCc2cc(OC)ccc21",
        "output": "212"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(Cl)c(N)c1.FC(F)(F)c1cc(Cl)nc(-c2cccnc2)n1>>Cc1ccc(Cl)c(Nc2cc(C(F)(F)F)nc(-c3cccnc3)n2)c1",
        "output": "161"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCN=C=NCCCN(C)C.Cc1ccc(C(=O)O)c2ccccc12.Cl.NC(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(F)cc1.O.On1nnc2ccccc21>>Cc1ccc(C(=O)NC(Cc2ccc(C(F)(F)F)cc2)C(O)c2ccc(F)cc2)c2ccccc12",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.C[C@@H](Cc1cc(C#N)ccc1Cl)Nc1nccc(N(C)c2ccnc(-c3ccccc3)n2)n1.Cl[Ni]Cl.[BH4-].[Na+]>>C[C@@H](Cc1cc(CN)ccc1Cl)Nc1nccc(N(C)c2ccnc(-c3ccccc3)n2)n1",
        "output": "175"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(Cl)cc(N(C)C2CCOCC2)c1OC.Cl.[Na+].[OH-]>>COc1c(C(=O)O)cc(Cl)cc1N(C)C1CCOCC1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)(Cc2cccc(Nc3nccs3)n2)CC1.ClC(Cl)Cl.O=C(O)C(F)(F)F>>OC1(Cc2cccc(Nc3nccs3)n2)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1ccc(N=C=O)cc1.COc1cc(Oc2ccc(N)cc2)ccn1>>CCc1ccc(NC(=O)Nc2ccc(Oc3ccnc(OC)c3)cc2)cc1",
        "output": "912"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C=O.O=C1c2cc(Cl)ccc2S(=O)(=O)N1CCCCBr.O=c1n(CC(F)(F)F)c2cc(F)ccc2n1C1CCNCC1>>O=C1c2cc(Cl)ccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)n(CC(F)(F)F)c3cc(F)ccc32)CC1",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COc1ccc([N+](=O)[O-])cc1N1CCN(CCS(C)(=O)=O)CC1.[Pd]>>COc1ccc(N)cc1N1CCN(CCS(C)(=O)=O)CC1",
        "output": "202"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cc1oc(-c2ccccc2)nc1CCl.O.O=C([O-])[O-].OCc1ccc(O)cc1.[K+].[K+]>>Cc1oc(-c2ccccc2)nc1COc1ccc(CO)cc1",
        "output": "760"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Brc1cccc2c3c([nH]c12)CC1CNC3C1.Cc1ccc(B2OC(C)(C)C(C)(C)O2)cn1>>Cc1ccc(-c2cccc3c4c([nH]c23)CC2CNC4C2)cn1",
        "output": "967"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(CN1C(=O)CCc2cc(N)ccc21)N1CCCC1.ClCCl.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+].[Na+].[OH-]>>CC(CN1CCCc2cc(N)ccc21)N1CCCC1",
        "output": "112"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.CNC(=O)c1cc(Cl)ccn1.C[Si](C)(C)[N-][Si](C)(C)C.O=C([O-])[O-].Oc1ccc2sc(Nc3ccc(Br)cc3)nc2c1.[K+].[K+].[K+]>>CNC(=O)c1cc(Oc2ccc3sc(Nc4ccc(Br)cc4)nc3c2)ccn1",
        "output": "351"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COC(=O)c1ccccc1-c1cccc2c1[nH]c1ccccc12.O.O=C1CCC(=O)N1Br>>COC(=O)c1ccccc1-c1cc(Br)cc2c1[nH]c1ccccc12",
        "output": "4"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC#N.CC(C)[Si](C#Cc1cc(Nc2cc(Oc3ccc(N)c4ccccc34)ccn2)cc(C(=O)NCCN2CCOCC2)c1)(C(C)C)C(C)C.COc1c(NC(=O)Oc2ccccc2)cc(C(C)(C)C)cc1C(N)=O>>COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(C#C[Si](C(C)C)(C(C)C)C(C)C)cc(C(=O)NCCN5CCOCC5)c4)c3)c3ccccc23)cc(C(C)(C)C)cc1C(N)=O",
        "output": "965"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCC.CCN(C(C)C)C(C)C.COc1ccc(N)cn1.ClCCl.O=C(Cl)c1ccccc1>>COc1ccc(NC(=O)c2ccccc2)cn1",
        "output": "501"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)N4CCC(CCCC(=O)O)CC4)c3)ccc21.Cl.F[P-](F)(F)(F)(F)F>>CNC(=O)CCCC1CCN(C(=O)Nc2cc(Oc3ccc4c(ccn4C(=O)NC)c3)ccn2)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CCNCC1.Fc1cccc(Nc2nc(-c3ccc(-c4ccccc4)cc3)cs2)n1.O>>CN1CCN(c2cccc(Nc3nc(-c4ccc(-c5ccccc5)cc4)cs3)n2)CC1",
        "output": "756"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.O=C1CCC(=O)N1Br.O=C1CCc2cccc(F)c2N1>>O=C1CCc2cc(Br)cc(F)c2N1",
        "output": "4"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cl.Nc1ccc(O)cc1O.O=C(O)c1ncc(Br)cc1Cl>>O=C(Nc1ccc(O)cc1O)c1ncc(Br)cc1Cl",
        "output": "548"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(CCCn2cc([N+](=O)[O-])cn2)CC1.CO.[Pd]>>CC(C)(C)OC(=O)N1CCC(CCCn2cc(N)cn2)CC1",
        "output": "628"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(CCc1c[nH]c2ccccc12)C(=O)CCCC(=O)O.CO.Cc1ccc(S(=O)(=O)O)cc1>>COC(=O)CCCC(=O)N(C)CCc1c[nH]c2ccccc12",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)OC(=O)/N=N/C(=O)OC(C)C.ClCCl.O=Cc1ccc(O)cc1.OCCCC(F)(F)F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=Cc1ccc(OCCCC(F)(F)F)cc1",
        "output": "478"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCc1cccc(CBr)c1.C1CCOC1.CC(C)(C)OC(=O)NCCO.[Cl-].[H-].[NH4+].[Na+]>>CC(C)(C)OC(=O)NCCOCc1cccc(CBr)c1",
        "output": "464"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClP(Cl)(Cl)(Cl)Cl.N#Cc1ccc(C(F)(F)F)nc1O.O=P(Cl)(Cl)Cl>>N#Cc1ccc(C(F)(F)F)nc1Cl",
        "output": "41"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CI.CN(C)C=O.Fc1ccc2cc[nH]c2n1.O.O=C([O-])[O-].[K+].[K+]>>Cn1ccc2ccc(F)nc21",
        "output": "570"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.O=C(Nc1ccc(Cl)nc1)C1CCN(C(=O)c2ccc(C(F)(F)F)cc2)CC1>>O=C(Nc1ccc(N2CCOCC2)nc1)C1CCN(C(=O)c2ccc(C(F)(F)F)cc2)CC1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)O.CN(C)CCCNC(=O)c1ccc(N)cc1.CN1C(=O)C(F)(F)CN(C2CCCCC2)c2nc(Cl)ncc21.Cc1ccccc1S(=O)(=O)O.O>>CN(C)CCCNC(=O)c1ccc(Nc2ncc3c(n2)N(C2CCCCC2)CC(F)(F)C(=O)N3C)cc1",
        "output": "941"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1c(Cl)cccc1C(=O)NC1CC1.Cc1c(Cl)cccc1C(=O)O.NC1CC1>>Cc1c(Cl)cccc1CNC1CC1",
        "output": "215"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COC(=O)C1CCc2ccc(Oc3cccc(N)c3)cc2C1.Cl.ClCCl.O=C(Cl)C1CC1>>COC(=O)C1CCc2ccc(Oc3cccc(NC(=O)C4CC4)c3)cc2C1",
        "output": "9"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(Cc2ccc(C(=O)O)cc2C(F)(F)F)CC1.CCOC(=O)c1ccc(CN2CCN(C(=O)OC(C)(C)C)CC2)c(Br)c1>>CC(C)(C)OC(=O)N1CCN(Cc2ccc(C(=O)O)cc2Br)CC1",
        "output": "5"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(C2CCNC2)cc1.O=C(O)C(=O)O.O=C(O)c1cnoc1-c1ccccc1Cl>>Cc1ccc(C2CCN(C(=O)c3cnoc3-c3ccccc3Cl)C2)cc1",
        "output": "975"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)N.O=S(=O)(Cl)c1ccc(Br)cc1>>CC(C)(C)NS(=O)(=O)c1ccc(Br)cc1",
        "output": "43"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)Oc1ccc(CO)cc1F.C[C@@H]1CCn2c(cc(Cl)nc2=O)N1C>>CC(C)Oc1ccc(COc2cc3n(c(=O)n2)CC[C@@H](C)N3C)cc1F",
        "output": "653"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCC(=O)Cl.CCCCCCCC/C=C\\CCCCCCCCO.CCOCC.c1ccncc1>>CCCCCCCC/C=C\\CCCCCCCCOC(=O)CCC",
        "output": "126"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CNC.O.O=C(OCc1ccccc1)N1CCC(S(=O)(=O)Cl)CC1.[H-].[Na+]>>CN(C)S(=O)(=O)C1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.O=C(NCCCO)C1=C(C(=O)Nc2ccc(Cl)cc2F)CCCC1.c1ccncc1>>CC(=O)OCCCNC(=O)C1=C(C(=O)Nc2ccc(Cl)cc2F)CCCC1",
        "output": "254"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)c1cc(C)[nH]n1.O.[Na+].[OH-]>>Cc1cc(C(=O)O)n[nH]1",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.CN(C)CCCCO.Fc1ccc(Br)cc1CBr.[H-].[Na+]>>CN(C)CCCCOCc1cc(Br)ccc1F",
        "output": "464"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCc1csc(N)n1.Cc1c(Cl)cccc1S(=O)(=O)Cl>>CCCc1csc(NS(=O)(=O)c2cccc(Cl)c2C)n1",
        "output": "637"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1cccc(-c2c(C(=O)c3ccccc3)cnc3c(C(F)(F)F)cccc23)c1.O=C(Cl)Cc1ccccc1Cl>>O=C(Cc1ccccc1Cl)Nc1cccc(-c2c(C(=O)c3ccccc3)cnc3c(C(F)(F)F)cccc23)c1",
        "output": "9"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1cccc(-c2ccnn2C)c1.[Na+].[OH-]>>Cn1nccc1-c1cccc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COCC1COc2cc3ncnc(Cl)c3cc2O1.Nc1cccc(I)c1>>COCC1COc2cc3ncnc(Nc4cccc(I)c4)c3cc2O1",
        "output": "352"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.COCC(CC(=O)OC)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2ccccc21.Cl.O>>COCC(CC(=O)O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2ccccc21",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1cnn2c(C)c(OCc3ccccc3)ccc12.[Pd]>>COC(=O)c1cnn2c(C)c(O)ccc12",
        "output": "264"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)COc1ccc(CCCS(=O)(=O)c2ccc(Cl)cc2)cc1NC(=O)c1ccc(C=Cc2nc3ccccc3s2)cc1.[Na+].[OH-]>>O=C(O)COc1ccc(CCCS(=O)(=O)c2ccc(Cl)cc2)cc1NC(=O)c1ccc(C=Cc2nc3ccccc3s2)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CCCCO.O.O=C(O)c1cc(Cl)nc(Cl)c1.[H-].[Na+]>>C=CCCCOc1cc(C(=O)O)cc(Cl)n1",
        "output": "433"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.CC(C)(C)CC(=O)O.Cc1cc(C#N)ccc1Cl.O=C1CCC(=O)N1Br>>N#Cc1ccc(Cl)c(CBr)c1",
        "output": "29"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CCCC(CC(=O)OC)c1ccc(Cl)c(NC(=O)[C@H](c2ccc(Cl)cc2)[C@@H](C)C(F)(F)F)c1.O.O=S(=O)(O)O>>CCCC(CC(=O)O)c1ccc(Cl)c(NC(=O)[C@H](c2ccc(Cl)cc2)[C@@H](C)C(F)(F)F)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1cnn(Cc2ccc3c(c2)N(CCOC)CCC3)c1.CO.[Na+].[OH-]>>COCCN1CCCc2ccc(Cn3cc(C(=O)O)cn3)cc21",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](N)[C@H](O)C1.COc1cc(-c2ncnc3c(C(=O)O)c(C)n(COCC[Si](C)(C)C)c23)c(OCC2CC2)cc1F>>COc1cc(-c2ncnc3c(C(=O)N[C@@H]4CCN(C(=O)OC(C)(C)C)C[C@H]4O)c(C)n(COCC[Si](C)(C)C)c23)c(OCC2CC2)cc1F",
        "output": "737"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCCCC1.C1CCOC1.CCOC(=O)c1cc(-c2ccc(NC(=O)c3cccc(-c4ccc(OC)cc4OC)c3)cc2)oc1C.CCOC(C)=O>>COc1ccc(-c2cccc(C(=O)Nc3ccc(-c4cc(C(=O)O)c(C)o4)cc3)c2)c(OC)c1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.COC(=O)c1cc(OCCF)cc(OCCF)c1.[Na+].[OH-]>>O=C(O)c1cc(OCCF)cc(OCCF)c1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "B#B.C1CCOC1.CC(Cc1ccc(OCC(=O)O)cc1)N(CCO)CC(O)c1csc(C(F)(F)F)n1.CCOC(C)=O.CO>>CC(Cc1ccc(OCCO)cc1)N(CCO)CC(O)c1csc(C(F)(F)F)n1",
        "output": "231"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CCOC[C@@H](O)COCc1ccccc1.CCCCCCCCCCCCCCCCBr.CN(C)C=O.[H-].[Na+]>>C=CCOC[C@H](COCc1ccccc1)OCCCCCCCCCCCCCCCC",
        "output": "95"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.CSCCCNc1nc(C(C)(C)C)ncc1C(=O)N(CC(C)C)[C@H]1C[C@@H](N)CN(C(=O)OC(C)(C)C)C1.ClCCCl.O>>CSCCCNc1nc(C(C)(C)C)ncc1C(=O)N(CC(C)C)[C@H]1C[C@@H](NS(C)(=O)=O)CN(C(=O)OC(C)(C)C)C1",
        "output": "493"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.Clc1ccc(-n2c(-c3ccccc3Cl)nc3c(NC4CCNCC4)ncnc32)cc1>>CS(=O)(=O)N1CCC(Nc2ncnc3c2nc(-c2ccccc2Cl)n3-c2ccc(Cl)cc2)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cc1ccc(C(C)C)c(OCC2CCN(CCCN3C(=O)c4ccccc4C3=O)CC2)c1.NN.O>>Cc1ccc(C(C)C)c(OCC2CCN(CCCN)CC2)c1",
        "output": "242"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)c1ccc(C(=O)NNC=C2C(=O)N(c3ccc(C(C)(C)C)cc3)N=C2C)cc1.Cl.[Na+].[OH-]>>CC1=NN(c2ccc(C(C)(C)C)cc2)C(=O)C1=CNNC(=O)c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CCCCCCBr.CN(C)C=O.O=C([O-])[O-].Oc1ccc(-c2ccccc2)cc1.[Cs+].[Cs+]>>CCOC(=O)CCCCCCOc1ccc(-c2ccccc2)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.Cc1cc(C)nc(N2CC3CNCC3C2)n1.Cc1cccc(-n2nccn2)c1C(=O)O>>Cc1cc(C)nc(N2CC3CN(C(=O)c4c(C)cccc4-n4nccn4)CC3C2)n1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CNC.Cl.On1nnc2ccccc21>>CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1c(C)c[nH]c1-c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)c1c(-c2ccccc2)[nH]c(Br)c1C",
        "output": "779"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Clc1ccc2ccccc2n1.OCCCCCCCCCCO>>OCCCCCCCCCCOc1ccc2ccccc2n1",
        "output": "433"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CCN(CC)CC.CCOC(=O)c1ccc(CC(=O)NC(CO)c2ccccc2N2CCCCC2)cc1OCC.ClC(Cl)Cl>>CCOC(=O)c1ccc(CC(=O)NC(COC(C)=O)c2ccccc2N2CCCCC2)cc1OCC",
        "output": "126"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OCc1cccc(Oc2ccccc2)c1.CO.Cl>>OCc1cccc(Oc2ccccc2)c1",
        "output": "497"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC(Cc1ccccc1)C(O)C(N)Cc1ccccc1.O=C(O)CCCCCNC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)NC(Cc1ccccc1)C(O)C(Cc1ccccc1)NC(=O)CCCCCNC(=O)OCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1c(N)sc2c1CCOC2.CCOC(C)=O>>Nc1sc2c(c1C(=O)O)CCOC2",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1cc(OCc2c(-c3ccc(Cl)cc3)noc2CO)nn1C.COC(=O)c1cc(OCc2c(-c3ccc(F)cc3)noc2CO)nn1C>>Cn1nc(OCc2c(-c3ccc(Cl)cc3)noc2CO)cc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)CC(=O)c1ccnc(C#N)c1.CC(C)N(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1C(F)(F)F>>CC(C)N(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2ccnc(C#N)c2)cc1C(F)(F)F",
        "output": "929"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cc1nc2c(n1C)CCN(C(=O)c1ccc([N+](=O)[O-])cc1)c1ccccc1-2.[C].[Pd]>>Cc1nc2c(n1C)CCN(C(=O)c1ccc(N)cc1)c1ccccc1-2",
        "output": "28"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CO.Nc1ncc2cc([N+](=O)[O-])ccc2n1.[H][H].[Pd]>>Nc1ccc2nc(N)ncc2c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)C=O.CCOC(C)=O.CCOc1cccc(OCC(=O)Nc2ccc(O)cc2N)c1.CO.Nc1ccccc1.[BH3-]C#N.[BH3-]C#N.[Cl-].[Cl-].[Cl-].[Cl-].[Na+].[Na+].[Zn+2].[Zn+2]>>CCOc1cccc(OCC(=O)Nc2ccc(O)cc2NCC(C)C)c1",
        "output": "336"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.NC1CC1.O=C(O)c1ccc(N2CCN(Cc3cnc4c(c3)NC(=O)[C@@H]3CSCCN43)CC2)cc1>>O=C(NC1CC1)c1ccc(N2CCN(Cc3cnc4c(c3)NC(=O)[C@@H]3CSCCN43)CC2)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1coc(-c2ccc(OC(F)F)c3oc4ccc([N+](=O)[O-])cc4c23)n1.CCOC(C)=O.CO.[C].[H][H].[Pd]>>CCOC(=O)c1coc(-c2ccc(OC(F)F)c3oc4ccc(N)cc4c23)n1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1ccc2c(c1)O[C@@H](CN)CO2.Cl.O=c1ccc2ccc(OCCCBr)cc2o1>>COc1ccc2c(c1)O[C@@H](CNCCCOc1ccc3ccc(=O)oc3c1)CO2",
        "output": "147"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Nc1cccc(C2CCN(CCCN)CC2)c1.O=C(O)C1(c2ccc(Cl)cc2)CCC1>>CC(=O)Nc1cccc(C2CCN(CCCNC(=O)C3(c4ccc(Cl)cc4)CCC3)CC2)c1",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COCCCc1nnc(-c2ccc(-c3ccccc3)nc2)n1-c1cccc(C(N)=O)c1C.O=P(Cl)(Cl)Cl>>COCCCc1nnc(-c2ccc(-c3ccccc3)nc2)n1-c1cccc(C#N)c1C",
        "output": "374"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)C(CN)C1(NCc2ccccc2)CCC1.CCO.[Pd]>>CC(C)(C)OC(=O)C(CN)C1(N)CCC1",
        "output": "561"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C#N)c1ccc([N+](=O)[O-])cn1.CCOC(C)=O.Cl[Sn]Cl.O.O.[Na+].[OH-]>>CC(C)(C#N)c1ccc(N)cn1",
        "output": "269"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cc1ccc(Oc2ccc([N+](=O)[O-])cc2C)cn1.[H][H].[Pd]>>Cc1ccc(Oc2ccc(N)cc2C)cn1",
        "output": "335"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCNCC1.Cc1nc(Br)sc1C(=O)N(Cc1cc(=O)[nH]c2ccccc12)c1ccccc1>>Cc1nc(N2CCN(C)CC2)sc1C(=O)N(Cc1cc(=O)[nH]c2ccccc12)c1ccccc1",
        "output": "657"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)[C@@H]1CCNC1.O=C(NCC1(O)CCCC(F)(F)C1)c1c(Cl)ccc2nc(Cl)ccc12>>CN(C)[C@@H]1CCN(c2ccc3c(C(=O)NCC4(O)CCCC(F)(F)C4)c(Cl)ccc3n2)C1",
        "output": "220"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1cccc(Br)n1.OCCC1CCNCC1>>OCCC1CCN(c2cccc(Br)n2)CC1",
        "output": "647"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1c(CN)c2cc(F)ccc2n1Cc1cccc2ccccc12.COC(=O)Cl.Cl.ClCCl>>CCOC(=O)c1c(CNC(=O)OC)c2cc(F)ccc2n1Cc1cccc2ccccc12",
        "output": "94"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CNCc1cc2cnccc2s1.Cl.Nc1ccc(/C=C/C(=O)O)cn1.O.O.On1nnc2ccccc21>>CN(Cc1cc2cnccc2s1)C(=O)/C=C/c1ccc(N)nc1",
        "output": "811"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)Cn1ccc2ccc(OCc3c(C)c(-c4ccc(C(F)(F)F)cc4)nn3C)cc21.[Li+].[OH-]>>Cc1c(-c2ccc(C(F)(F)F)cc2)nn(C)c1COc1ccc2ccn(CC(=O)O)c2c1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.Cc1cc(S(=O)(=O)c2ccc(N)nc2)ccc1Br.[K+]>>Cc1cc(S(=O)(=O)c2ccc(N)nc2)ccc1B1OC(C)(C)C(C)(C)O1",
        "output": "942"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1ccc(-c2ccc(OCC3CCN(CC(C)(C)F)CC3)c(C#N)c2)cc1.O.O.[Li]O>>CC(C)(F)CN1CCC(COc2ccc(-c3ccc(C(=O)O)cc3)cc2C#N)CC1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCC2=NCCCN2CC1.C1CCOC1.CC(C)(C)OC(=O)NC1(C(=O)O)CC1C(F)F.NS(=O)(=O)C1CC1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)NC1(C(=O)NS(=O)(=O)C2CC2)CC1C(F)F",
        "output": "644"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCOc1ccc(S(=O)(=O)Cl)cc1.N>>CCCCOc1ccc(S(N)(=O)=O)cc1",
        "output": "245"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N(C[C@H](O)COc1ccccc1)C[C@H]1CCc2cc(I)ccc2O1.CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O.c1c[nH]cn1>>CC(C)(C)OC(=O)N(C[C@H]1CCc2cc(I)ccc2O1)C[C@@H](COc1ccccc1)O[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)c1cc(C(F)(F)F)nn1C1CCN(C(=O)OC(C)(C)C)CC1.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(n2nc(C(F)(F)F)cc2C(=O)O)CC1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "FC(F)(F)c1nnc2ccc(N3CCNCC3)nn12.O=Cc1cccc2c1OCO2>>FC(F)(F)c1nnc2ccc(N3CCN(Cc4cccc5c4OCO5)CC3)nn12",
        "output": "567"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CCS)C(=O)OC(C)(C)C.OCCCBr>>CC(C)(C)OC(=O)N[C@@H](CCSCCCO)C(=O)OC(C)(C)C",
        "output": "185"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CO.Cl.ClCCl.O=C(O)COCCc1cccc(F)c1.On1nnc2ccccc21>>COC(=O)COCCc1cccc(F)c1",
        "output": "195"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ccc(C(C)=O)cn1.CO.[BH4-].[Na+]>>CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ccc(C(C)O)cn1",
        "output": "449"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.C[C@]1([C@H]2CC[C@@]3(C)[C@@H](CC[C@@]3(O)c3ccccc3)[C@@H]2CN)CC[C@H](O)C[C@@H]1CO>>CC(=O)O[C@@]1(c2ccccc2)CC[C@H]2[C@H](CN)[C@@H]([C@@]3(C)CC[C@H](O)C[C@@H]3CO)CC[C@@]21C",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)c1cccc(O)c1.CN(C)C=O.Cc1cc([N+](=O)[O-])c(Cl)cc1F.O=C([O-])[O-].[K+].[K+]>>Cc1cc([N+](=O)[O-])c(Cl)cc1Oc1cccc(C(C)C)c1",
        "output": "564"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(C(C)C)C(C)C.CNC(=O)C1(N(C)Cc2cc3c(Nc4cccc(Cl)c4F)ncnc3cc2OC)CNC1.ClCCCl.[Na+]>>CNC(=O)C1(N(C)Cc2cc3c(Nc4cccc(Cl)c4F)ncnc3cc2OC)CN(C)C1",
        "output": "217"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.ClCC1CO1.NC(=O)c1sc(-n2cnc3ccc(O)cc32)nc1-c1cccc(Cl)c1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>NC(=O)c1sc(-n2cnc3ccc(OCC4CO4)cc32)nc1-c1cccc(Cl)c1",
        "output": "15"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.CC(C)c1ccccc1.Cl.S=C=S.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)c1ccc(C(C)C)cc1",
        "output": "31"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C(=O)O)CCC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)c1ccc2c(c1)OC[C@@H](C(C)C)NC2.F[P-](F)(F)(F)(F)F.O>>COC(=O)c1ccc2c(c1)OC[C@@H](C(C)C)N(C(=O)C1(C)CCC1)C2",
        "output": "633"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C1(Nc2nc(Nc3ccc(C(=O)OC(C)(C)C)cc3)nc(OCC(F)(F)F)n2)CC1.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)C1(Nc2nc(Nc3ccc(C(=O)O)cc3)nc(OCC(F)(F)F)n2)CC1",
        "output": "752"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.NCCc1ccccc1[N+](=O)[O-].[Pd]>>NCCc1ccccc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[Si](C)(C)[N-][Si](C)(C)C.Nc1ccc(C(F)(F)F)cc1[N+](=O)[O-].[Na+]>>CC(C)(C)OC(=O)Nc1ccc(C(F)(F)F)cc1[N+](=O)[O-]",
        "output": "735"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cl.O=C(O)Cc1cccc(Br)c1>>COC(=O)Cc1cccc(Br)c1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCC(O)COc1ccc(C#N)cc1.CN(C)c1ccncc1.CS(=O)(=O)Cl.ClCCl.O.c1ccncc1>>CC(C)(C)OC(=O)NCC(COc1ccc(C#N)cc1)OS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)[O-].CCOC(C)=O.O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc2cccc(-c3ccccc3)c2c1.[Na+]>>O=S(=O)(Oc1ccc2cccc(-c3ccccc3)c2c1)C(F)(F)F",
        "output": "843"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.COC(=O)COC1CCNCC1.COc1cccc([C@H]2O[C@H](CCC(=O)O)c3cccn3-c3ccc(Cl)cc32)c1OC.Cl.ClCCl.On1nnc2ccccc21>>COC(=O)COC1CCN(C(=O)CC[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3-n3cccc32)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)[C@@H]1CCN(C(=O)OC(C)(C)C)[C@H]1c1cc([N+](=O)[O-])ccc1S(=O)(=O)CC.CO.[H][H].[Pd]>>CCOC(=O)[C@@H]1CCN(C(=O)OC(C)(C)C)[C@H]1c1cc(N)ccc1S(=O)(=O)CC",
        "output": "71"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.O.O=Cc1cc(Br)ccc1N1CCC(O)C1.[H-].[Na+]>>COC1CCN(c2ccc(Br)cc2C=O)C1",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=c1cc(OCc2ccc(F)cc2)ccn1-c1ccc(O)cc1.O=c1cc(OCc2ccccc2)ccn1-c1ccc(O)cc1.OCCN1CCC[C@H]1CF>>O=c1cc(OCc2ccc(F)cc2)ccn1-c1ccc(OCCN2CCC[C@H]2CF)cc1",
        "output": "478"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COc1ccc(Cn2c(=O)c3cc(C=O)ccc3n(C3CCOCC3)c2=O)cc1OC.[BH4-].[Na+]>>COc1ccc(Cn2c(=O)c3cc(CO)ccc3n(C3CCOCC3)c2=O)cc1OC",
        "output": "356"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)[N-]C(C)C.CCOC(C)=O.COc1c(C)cc(F)cc1F.II.[Li+]>>COc1c(C)cc(F)c(I)c1F",
        "output": "372"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.COc1ncccc1CN1CCCCC1CCO.CS(C)=O.O=C([O-])O.[Na+]>>COc1ncccc1CN1CCCCC1CC=O",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Nc1ccnc(C#Cc2cccc(N)c2)c1.CN(C)C=O.Clc1ncc(Cl)c(Cl)n1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)Nc1ccnc(C#Cc2cccc(Nc3nc(Cl)ncc3Cl)c2)c1",
        "output": "352"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.NO.O=C1CCN(CCCOCc2ccccc2)CC1>>ON=C1CCN(CCCOCc2ccccc2)CC1",
        "output": "86"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.N#Cc1ccc(Cl)cc1N[C@H]1CCCC[C@@H]1N>>CC(C)(C)OC(=O)N[C@H]1CCCC[C@@H]1Nc1cc(Cl)ccc1C#N",
        "output": "631"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(O)CNC1.CCN(CC)CC.CCOC(=O)c1cn(C2CC2)c2c(F)c(F)c(F)cc2c1=O.Cl.O.c1ccncc1>>CCOC(=O)c1cn(C2CC2)c2c(F)c(N3CC(C)(O)C3)c(F)cc2c1=O",
        "output": "676"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CO.COc1ccccc1N1CCNCC1.ClCCl.O=C([O-])[O-].O=C1CS(=O)CN1CCCCBr.[I-].[K+].[K+].[Na+]>>COc1ccccc1N1CCN(CCCCN2CS(=O)CC2=O)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.CO.Cl.Cn1c2c(c3ccc(-n4ccc(OCc5ccccc5)cc4=O)cc31)CN(C(=O)C1CCNC1)CC2.[Na+]>>CN1CCC(C(=O)N2CCc3c(c4ccc(-n5ccc(OCc6ccccc6)cc5=O)cc4n3C)C2)C1",
        "output": "217"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCC1CC1.CC(C)=O.[K+].[OH-].c1c[nH]cn1>>c1cn(CC2CC2)cn1",
        "output": "495"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2ccccc2-c2nnn(C(C)(C)c3ccccc3)n2)cc1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC(C)(c1ccccc1)n1nnc(-c2ccccc2-c2ccc(CO)cc2)n1",
        "output": "444"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1noc(C)c1-c1cc(C(N)=O)c2[nH]c3cc(N)ccc3c2c1.ClCCl.O=S(=O)(Cl)CCCCl>>Cc1noc(C)c1-c1cc(C(N)=O)c2[nH]c3cc(NS(=O)(=O)CCCCl)ccc3c2c1",
        "output": "194"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#CCBr.CN(C)C=O.Cc1c(C)c(C=O)c2ccccc2c1O.[H-].[Na+]>>CC#CCOc1c(C)c(C)c(C=O)c2ccccc12",
        "output": "154"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCOC(=O)C1(C)CCC(OC(=O)/C=C/c2ccc(OC(C)=O)c(OC)c2)CC1.CO.Cl.O=C([O-])[O-].[K+].[K+]>>C=CCOC(=O)C1(C)CCC(OC(=O)/C=C/c2ccc(O)c(OC)c2)CC1",
        "output": "22"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C.ClCCl.F[P-](F)(F)(F)(F)F.NCCCN1CCCC1.O.[Na+].[OH-]>>COc1cc(C(=O)NCCCN2CCCC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.CC1CCc2c(Cl)c(F)cc3c(=O)c(C(=O)O)cn1c23.CN(C)P(=O)(N(C)C)N(C)C>>CC1CCc2c(Cl)c(N3CCOCC3)cc3c(=O)c(C(=O)O)cn1c23",
        "output": "26"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCc1cc(CCC=O)n(Cc2ccccc2)n1.Fc1ccccc1N1CCNCC1.[Na+]>>CCCc1cc(CCCN2CCN(c3ccccc3F)CC2)n(Cc2ccccc2)n1",
        "output": "484"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.COc1nc(N2CCOCC2)cc2c1N(C(C)=O)[C@@H](C1CC1)[C@H](C)[C@H]2Nc1cccc(C)n1.[I-].[Na+]>>CC(=O)N1c2c(cc(N3CCOCC3)nc2O)[C@H](Nc2cccc(C)n2)[C@@H](C)[C@@H]1C1CC1",
        "output": "408"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cl.ClCCl.N[C@@H](Cc1ccccc1I)C(=O)O>>COC(=O)[C@@H](N)Cc1ccccc1I",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)Nc1nc2cc(Cl)ccc2nc1OC.COc1ccc(N2CCNCC2)cc1>>COc1ccc(N2CCN(C(=O)Nc3nc4cc(Cl)ccc4nc3OC)CC2)cc1",
        "output": "613"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOCC.CN(C)c1ccncc1.Cl.Cl.ClCCl.NCc1ccc(C(c2cc(F)ccc2F)S(=O)(=O)c2ccc(Cl)cc2)nc1.O=C(O)Cc1cccnc1.O=C([O-])O.[Na+]>>O=C(Cc1cccnc1)NCc1ccc(C(c2cc(F)ccc2F)S(=O)(=O)c2ccc(Cl)cc2)nc1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Brc1ccc(-c2nccs2)nc1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC1CCCC1.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc(-c3nccs3)nc2)OC1(C)C",
        "output": "943"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Clc1cc2c(nn1)-c1ccccc1CC2.[NH4+].c1cnc(N2CCNCC2)nc1>>c1cnc(N2CCN(c3cc4c(nn3)-c3ccccc3CC4)CC2)nc1",
        "output": "406"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CCOCC.CN(C)C=O.CN(C)c1ccncc1.CN1CCN(c2cccc3ccc(N)cc23)CC1.O=[N+]([O-])c1ccccc1F>>CN1CCN(c2cccc3ccc(Nc4ccccc4[N+](=O)[O-])cc23)CC1",
        "output": "609"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)CCN1C(=O)N2Cc3c(c4ccccc4n3Cc3ccc(F)cc3)CC2(C)C1=O.CO.[Na+].[OH-]>>CC12Cc3c(n(Cc4ccc(F)cc4)c4ccccc34)CN1C(=O)N(CCC(=O)O)C2=O",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(c2ccncc2)CO1.CN(C)C=O.Fc1cc(Cl)cc2c3c([nH]c12)C[C@@H]1CCCN1C3.[H-].[Na+]>>CC(O)(Cn1c2c(c3cc(Cl)cc(F)c31)CN1CCC[C@H]1C2)c1ccncc1",
        "output": "749"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(C(C)C)C(C)C.O.O=[N+]([O-])c1ccc(N2CCNCC2)cc1>>CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1",
        "output": "694"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CC[C@H](C)[C@H](N)CO.ClCCl.O=S(=O)(Cl)c1cccs1>>CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1cccs1",
        "output": "600"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)O.CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1ccccc1.Nc1ccccc1N.O=C1c2ccc(Cl)cc2CCc2ccc(OCCN3CCOCC3)cc21.[K+].[Pd+2]>>Nc1ccccc1Nc1ccc2c(c1)CCc1ccc(OCCN3CCOCC3)cc1C2=O",
        "output": "510"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.O.O=C1NCCCC1NC(c1ccccc1)(c1ccccc1)c1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>c1ccc(C(NC2CCCNC2)(c2ccccc2)c2ccccc2)cc1",
        "output": "112"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)c1ccccn1.COc1cc(F)c2nccc(O)c2c1.Cc1cccc(C)n1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1cc(F)c2nccc(OS(=O)(=O)C(F)(F)F)c2c1",
        "output": "731"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)CCCCCNC(=O)OCc1ccccc1.CO.[Pd]>>CC(C)(C)OC(=O)CCCCCN",
        "output": "574"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1cc(-c2nc3ccc(CN4CCN(C)CC4)cc3c(=O)[nH]2)cc(C)c1OCCO[Si](C)(C)C(C)(C)C.[F-]>>Cc1cc(-c2nc3ccc(CN4CCN(C)CC4)cc3c(=O)[nH]2)cc(C)c1OCCO",
        "output": "708"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1cc(OC(F)F)cc(C(=O)OC)c1.Cl.[Na+].[OH-]>>COC(=O)c1cc(OC(F)F)cc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc(Nc2ccc(Cl)cn2)c1.O.[Na+].[OH-]>>O=C(O)c1cccc(Nc2ccc(Cl)cn2)c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)Nc1ncc(CCN)s1.CC(Cl)Cl.O=CC1CCOCC1.[Na+]>>CC(C)(C)OC(=O)Nc1ncc(CCNCC2CCOCC2)s1",
        "output": "426"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.COCCn1nc(-c2ccc(O)cc2)oc1=O.CS(=O)(=O)OCC1CCCOC1.O=C([O-])[O-].[K+].[K+]>>COCCn1nc(-c2ccc(OCC3CCCOC3)cc2)oc1=O",
        "output": "702"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)C=O.ClCCl.Nc1c(F)ccc(O)c1Cl.O.O=C(Cl)C(=O)Cl.O=C(O)c1cc(-c2cccc(F)c2)ccc1F.O=C([O-])O.[Na+]>>O=C(Nc1c(F)ccc(O)c1Cl)c1cc(-c2cccc(F)c2)ccc1F",
        "output": "50"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(-c2nc(-c3ccc4[nH]ccc4c3)no2)cc1Cl.COc1ccc2[nH]ccc2c1>>COc1ccc2c(c1)CCN2",
        "output": "672"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cc(C)n(-c2ccc(O)cc2)n1.Cl.ClCCN1CCCCC1>>Cc1cc(C)n(-c2ccc(OCCN3CCCCC3)cc2)n1",
        "output": "74"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCNc1c([N+](=O)[O-])c(Cl)nc2ccccc12.CC[n+]1ccc(-c2cc[n+](CC)cc2)cc1.ClCCl.O.O=C([O-])[O-].O=S(=O)([O-])S(=O)(=O)[O-].[Br-].[Br-].[K+].[K+].[Na+].[Na+]>>C=CCNc1c(N)c(Cl)nc2ccccc12",
        "output": "269"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CNC.CO.FC(F)(F)Oc1ccc(C2CCc3c(Cl)nc(Cl)nc32)cc1>>CN(C)c1nc(Cl)nc2c1CCC2c1ccc(OC(F)(F)F)cc1",
        "output": "296"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COc1ccc(C#N)c(Cl)n1.Cl[Pd]Cl.O=C([O-])[O-].OB(O)c1cc(F)cc(F)c1.[Na+].[Na+]>>COc1ccc(C#N)c(-c2cc(F)cc(F)c2)n1",
        "output": "865"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)CCC(=O)O.CCCCCCCC(=O)O[Sn](CCCC)(CCCC)OC(=O)CCCCCCC.CCCCOCCO.Cc1ccccc1C>>CCCCOCCOC(=O)CCC(C)=O",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccccc1.O=C(O)c1ccc(Br)cc1Cl.O=C([O-])[O-].OB(O)c1ccc(F)cc1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(O)c1ccc(-c2ccc(F)cc2)cc1Cl",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[SiH2]OC(C)(C)[C@H]1CCCN1c1cncc(Br)c1.CN1C(=O)CCc2cc(B3OC(C)(C)C(C)(C)O3)ccc21>>CN1C(=O)CCc2cc(-c3cncc(N4CCC[C@@H]4C(C)(C)O[SiH2]C(C)(C)C)c3)ccc21",
        "output": "938"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc2c(c1)CCn1c-2cc(Cl)nc1=O.Nc1c(F)cccc1Br>>COc1ccc2c(c1)CCn1c-2cc(Nc2c(F)cccc2Br)nc1=O",
        "output": "161"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COS(=O)(=O)OC.O.O=C1CCc2cc(O)ccc2N1.[Na+].[OH-]>>COc1ccc2c(c1)CCC(=O)N2",
        "output": "317"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)C(=O)Cl.CCCCCC.CCN(CC)CC.CCOC(C)=O.ClCCl.O=Cc1ccc(O)cc1O>>CC(C)(C)C(=O)Oc1ccc(C=O)c(O)c1",
        "output": "111"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.Nc1cccc(N)c1.O=[N+]([O-])c1cc(Br)ccc1F>>Nc1cccc(Nc2ccc(Br)cc2[N+](=O)[O-])c1",
        "output": "609"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COc1ccccc1B(O)O.O=C1c2ccccc2C(=O)N1Cc1cccc(Nc2cc(Cl)ncn2)c1.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>COc1ccccc1-c1cc(Nc2cccc(CN3C(=O)c4ccccc4C3=O)c2)ncn1",
        "output": "884"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C1COCCO1.CN1CCN(c2cccc(CN(C)c3cnc4cc(-c5cnn(C(=O)OC(C)(C)C)c5)ccc4n3)c2)CC1.Cl.N>>CN1CCN(c2cccc(CN(C)c3cnc4cc(-c5cn[nH]c5)ccc4n3)c2)CC1",
        "output": "896"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1.Nc1ccc(-c2cnc(CNS(=O)(=O)C(F)(F)F)s2)cc1.O=C=Nc1cc(F)cc(F)c1>>O=C(Nc1ccc(-c2cnc(CNS(=O)(=O)C(F)(F)F)s2)cc1)Nc1cc(F)cc(F)c1",
        "output": "473"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOCC.N#Cc1cc(-c2ccc(OC(F)(F)F)cc2)nc(-c2ccc(OC(F)(F)F)cc2)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCc1cc(-c2ccc(OC(F)(F)F)cc2)nc(-c2ccc(OC(F)(F)F)cc2)c1",
        "output": "175"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](O)[C@H]1C(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.NCc1cc(-c2cnc(C(F)(F)F)nc2)ccc1C(N)=O>>CC(C)(C)OC(=O)N1CC[C@@H](O)[C@H]1C(=O)NCc1cc(-c2cnc(C(F)(F)F)nc2)ccc1C(N)=O",
        "output": "797"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COc1cccc(-c2nc(Cl)nc(Cl)n2)c1.Nc1ccc(O)cc1.O=C([O-])O.[Na+]>>COc1cccc(-c2nc(Cl)nc(Nc3ccc(O)cc3)n2)c1",
        "output": "592"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)c1cc(Cc2ccc(F)cc2)on1.O.[Na+].[OH-]>>O=C(O)c1cc(Cc2ccc(F)cc2)on1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)CCOS(C)(=O)=O.O=C1S/C(=C\\c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)C(=O)N1C[C@@H]1CCCN1>>CS(=O)(=O)CCN1CCC[C@H]1CN1C(=O)S/C(=C\\c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)C1=O",
        "output": "496"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN.Cl.O=C(Cl)c1ccncc1Cl>>CNC(=O)c1ccncc1Cl",
        "output": "271"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NC1CCN(CCN2C(=O)COc3ccc([N+](=O)[O-])cc32)CC1.O=Cc1ccc2c(n1)NC(=O)CO2.[BH3-]C#N.[Na+]>>O=C1COc2ccc(CNC3CCN(CCN4C(=O)COc5ccc([N+](=O)[O-])cc54)CC3)nc2N1",
        "output": "775"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C(=N)N(C)C.CS(C)=O.Fc1cnc(Cl)nc1.O.O=C(NC1=N[C@@]2(c3ccccc3)CNC[C@H]2CS1)c1ccccc1>>O=C(NC1=N[C@@]2(c3ccccc3)CN(c3ncc(F)cn3)C[C@H]2CS1)c1ccccc1",
        "output": "36"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)O.CCOC(=O)[C@@H]1CC[C@@H](N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1.O>>O=C(O)[C@@H]1CC[C@@H](N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C(Cl)CCCCCBr.O=C1CCc2ccccc2N1>>O=C1CCc2cc(C(=O)CCCCCBr)ccc2N1",
        "output": "31"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CN2CCN1CC2.CC(c1ccc(O)cc1Cl)C(O)(c1ccc2oc(=O)n(C)c2c1)C(F)(F)F.CCN(CC)CC.CN(C)C=O.COC(=O)c1ccc(Cl)nc1.O>>COC(=O)c1ccc(Oc2ccc(C(C)C(O)(c3ccc4oc(=O)n(C)c4c3)C(F)(F)F)c(Cl)c2)nc1",
        "output": "516"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCc1ccc(C(N)=O)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CCc1ccc(CN)cc1",
        "output": "215"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](OCC1CC(N)C1O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)(c1ccccc1)c1ccccc1.CCN(CC)CC.CCOCC.CN(C)C=O.Nc1nc(O)c([N+](=O)[O-])c(Cl)n1>>CC(C)(C)[Si](OCC1CC(Nc2nc(N)nc(O)c2[N+](=O)[O-])C1O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)(c1ccccc1)c1ccccc1",
        "output": "110"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC1(C(O)C(=O)NC2CC2)CC1.ClCCl.O=C(O)C(F)(F)F>>NC1(C(O)C(=O)NC2CC2)CC1",
        "output": "538"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.O=C1COc2cc([N+](=O)[O-])ccc2N1.[H][H].[Pd]>>Nc1ccc2c(c1)OCC(=O)N2",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CC[Si](CC)(CC)OC(C1CCN(C(=O)OCc2ccccc2)CC1)C(F)(F)F.[Pd]>>CC[Si](CC)(CC)OC(C1CCNCC1)C(F)(F)F",
        "output": "428"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cl.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3OCC4)CC2)CC1.O=C(O)c1ccc(N2CCOCC2)cc1>>O=C(N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3OCC4)CC2)CC1)c1ccc(N2CCOCC2)cc1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)c1c(CC)nc2c(cnn2CC)c1NC1CCOCC1.Cc1ccccc1.ClCCl.[H-]>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CO",
        "output": "383"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(Cc1ccc(O)cc1)C(=O)OC.CCOC(C)=O.COCc1ccc(CCO)cc1.ClCCl.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCC(Cc1ccc(OCCc2ccc(COC)cc2)cc1)C(=O)OC",
        "output": "478"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCC.ClCCl.O=[Mn]=O.OCc1cnc(Cl)c(Cl)c1>>O=Cc1cnc(Cl)c(Cl)c1",
        "output": "520"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)c1ccc(B(O)O)cc1.O=Cc1ccc(Br)s1>>CS(=O)(=O)c1ccc(-c2ccc(C=O)s2)cc1",
        "output": "864"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccc(F)cc1Nc1nc(Cl)cc(Cl)n1.[Pd]>>Nc1ccc(F)cc1Nc1nc(Cl)cc(Cl)n1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(NC(=O)OC(C)(C)C)c1nc2ccc(F)cc2c(Cl)c1-c1ccccn1.CNC.CO>>CC(NC(=O)OC(C)(C)C)c1nc2ccc(F)cc2c(N(C)C)c1-c1ccccn1",
        "output": "398"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1onc(-c2ccccc2)c1-c1nnc2n1Cc1ccc(OC3CCN(C(=O)OC(C)(C)C)CC3)cc1-2.O=C(O)C(F)(F)F>>Cc1onc(-c2ccccc2)c1-c1nnc2n1Cc1ccc(OC3CCNCC3)cc1-2",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)C1OCCc2c1ccc(F)c2I.CO.O.O.[Li]O>>O=C(O)C1OCCc2c1ccc(F)c2I",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.NCC12CC3CC(CC(C3)C1)C2.O.O=C(O)c1cn(-c2ncccn2)c2ccccc12>>O=C(NCC12CC3CC(CC(C3)C1)C2)c1cn(-c2ncccn2)c2ccccc12",
        "output": "674"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CNCCN1.CC(=O)N(C)C.Fc1ccc(Cl)cc1Cl>>Clc1ccc(N2CCNCC2)c(Cl)c1",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COCc1nc2c(N)nc3cc(CCCNS(C)(=O)=O)ccc3c2n1CC(C)(C)O.ClCCl>>CC(C)(O)Cn1c(CO)nc2c(N)nc3cc(CCCNS(C)(=O)=O)ccc3c21",
        "output": "423"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(-c3ccc4c(c3)C(=O)NC4)ccc2c1.Cl.ClCCl.O=C([O-])O.[Na+]>>O=C1NCc2ccc(-c3ccc4cc(O)ccc4c3Oc3ccc(OCCN4CCCCC4)cc3)cc21",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cc(C#N)c(=O)[nH]c1C(C)C.O=C([O-])[O-].O=P(Cl)(Cl)Cl.[K+].[K+]>>CCOC(=O)c1cc(C#N)c(Cl)nc1C(C)C",
        "output": "100"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)c1cc(S(=O)(=O)c2ccc(CCNC(=O)C(F)(F)F)cc2)ccc1OC.Cl>>CCOC(=O)c1cc(S(=O)(=O)c2ccc(CCN)cc2)ccc1OC",
        "output": "805"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NC1CCN(CC2Cc3c(F)cnc4ccc(=O)n2c34)CC1.ClCCl.O=C(O)C(F)(F)F>>NC1CCN(CC2Cc3c(F)cnc4ccc(=O)n2c34)CC1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNC(=O)COc1cc(C#N)ccc1CN.Cl.O=C(O)c1cccc(C(F)(F)F)c1>>CNC(=O)COc1cc(C#N)ccc1CNC(=O)c1cccc(C(F)(F)F)c1",
        "output": "753"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCOCCOCCOCCOCCO1.CC#N.CC(=O)N(C)C.C[Si](C)(C)[N-][Si](C)(C)C.N#C[C@@H]1C[C@@H]1CO.O=C(NC12CC(C1)C2)c1cc(N2CCC(c3n[nH]c4ncccc34)CC2)nc(Cl)n1.[K+]>>N#C[C@@H]1C[C@@H]1COc1nc(C(=O)NC23CC(C2)C3)cc(N2CCC(c3n[nH]c4ncccc34)CC2)n1",
        "output": "37"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.Cc1c(F)cc(F)cc1[N+](=O)[O-].[Pd]>>Cc1c(N)cc(F)cc1F",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC2)CC1C(=O)[O-].CC([NH2+]Cc1ccccc1)c1ccccc1.CCOC(C)=O.Cl.[Cl-].[Na+]>>CC(C)(C)OC(=O)N1CCC2(CC2)CC1C(=O)O",
        "output": "151"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1ccc(OCc2ccccc2)cc1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CC(C)(C)[PH+](C(C)(C)C)C(C)(C)C.CCO.CCOC(C)=O.Cc1ccccc1.FC(F)(F)Oc1ccc(OC2CCNCC2)cc1.O.[Na+].[Pd+2].c1ccc([B-](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>FC(F)(F)Oc1ccc(OC2CCN(c3ccc(OCc4ccccc4)cc3)CC2)cc1",
        "output": "294"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CCOc1ccc([N+](=O)[O-])c(Cl)c1.CCOC(C)=O.CO.ClCCl>>CCN(CC)CCOc1ccc(N)c(Cl)c1",
        "output": "202"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)C/C=C\\c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)OC(C)(C)C)OC[C@H]1CCN21.ClCCl.O=C(O)C(F)(F)F>>CCN(CC)C/C=C\\c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)OC[C@H]1CCN21",
        "output": "752"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(C)N(CCNC(=O)[C@H](Cc1ccccc1)NC(=O)Nc1ccc(Oc2ccc(Cl)cc2)cc1)C(C)C.CCN(CC)CC.CCOC(C)=O.Cl.ClCCl.O=C=Nc1ccc(Oc2ccccc2)cc1>>CC(C)N(CCNC(=O)[C@H](Cc1ccccc1)NC(=O)Nc1ccc(Oc2ccccc2)cc1)C(C)C",
        "output": "253"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCc1ccc(OC(C)CCOC(C)=O)c(C(=O)c2ccccc2)c1.CO.O.O=C([O-])[O-].[K+].[K+]>>CCc1ccc(OC(C)CCO)c(C(=O)c2ccccc2)c1",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NCCc1ccc(C(=O)O)cc1.CCI.CN(C)C=O.O.O=C([O-])O.O=C([O-])[O-].[K+].[K+].[Na+]>>CCOC(=O)c1ccc(CCNC(=O)OC(C)(C)C)cc1",
        "output": "196"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1C(=O)Nc2ccccc2C1C.O=C(Cl)CCl>>CC1C(=O)Nc2ccc(C(=O)CCl)cc2C1C",
        "output": "31"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCCOc1cccc(N)c1.CC(C)S(=O)(=O)Cl>>CC(C)S(=O)(=O)Nc1cccc(OCCNC(=O)OC(C)(C)C)c1",
        "output": "194"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.COC(=O)Cc1c(F)cc2ncccc2c1F.ClC(Cl)(Cl)Cl.c1ccncc1>>COC(=O)Cc1c(F)cc2ncc(Br)cc2c1F",
        "output": "292"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "N[C@H]1CCN(CCc2ccccc2)C1.O=S(=O)(Cl)C12CC3CC(CC(C3)C1)C2>>O=S(=O)(N[C@H]1CCN(CCc2ccccc2)C1)C12CC3CC(CC(C3)C1)C2",
        "output": "493"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CNCCO.Cc1ccc(Oc2ccc(Nc3ncnc4cccc(O[C@@H](C)C(=O)O)c34)cc2C)cn1>>Cc1ccc(Oc2ccc(Nc3ncnc4cccc(O[C@@H](C)C(=O)N(C)CCO)c34)cc2C)cn1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.N.O=S(Cl)Cl.[N-]=[N+]=NCCc1ccc(C(N)=O)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NCCc1ccc(C(N)=O)cc1",
        "output": "89"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Nc1cc([N+](=O)[O-])ccc1F.OC1CCNC1>>Nc1cc([N+](=O)[O-])ccc1N1CCC(O)C1",
        "output": "26"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.Fc1cccc2cc[nH]c12.[BH3-]C#N.[Na+].[Na+].[OH-]>>Fc1cccc2c1NCC2",
        "output": "672"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N1CCC(Oc2ccc(I)cc2)CC1.CNC(=O)c1cc[nH]c1.Cn1ccc(C(=O)O)c1.Ic1ccc(OC2CCN(C3CCC3)CC2)cc1>>CNC(=O)c1ccn(-c2ccc(OC3CCN(C(C)C)CC3)cc2)c1",
        "output": "267"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.Cn1ccc2ncc(Br)cc21.O=C(OO)c1cccc(Cl)c1>>Cn1ccc2c1cc(Br)c[n+]2[O-]",
        "output": "820"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.COCCNCc1nc2c(c(=O)[nH]1)COCC2.COc1ccc(C(=O)C2CCN(CC(=O)O)CC2)cc1>>COCCN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(OC)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCC(CC)(c1ccc(OCC(=O)C(C)(C)C)c(C)c1)c1ccc2cc(C(=O)O)ccc2c1.Cl.[BH4-].[Na+]>>CCC(CC)(c1ccc(OCC(O)C(C)(C)C)c(C)c1)c1ccc2cc(C(=O)O)ccc2c1",
        "output": "91"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)CC(c2cccc(N3CCOCC3)c2)Nc2c(C(=O)O)cc(Cl)cc21.CN(C)C=O.CS(N)(=O)=O.O.O=C(n1ccnc1)n1ccnc1.[H-].[Na+]>>CC1(C)CC(c2cccc(N3CCOCC3)c2)Nc2c(C(=O)NS(C)(=O)=O)cc(Cl)cc21",
        "output": "580"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(N2CCC(Oc3ccccc3C(F)(F)F)CC2)nn1.Cl.[Li+].[OH-]>>O=C(O)c1ccc(N2CCC(Oc3ccccc3C(F)(F)F)CC2)nn1",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)C(=O)Cl.CC(C)=O.CO.ClCCl.O=C=O.OCCC(O)CCOCc1ccccc1.c1ccncc1>>CC(C)(C)C(=O)OCCC(O)CCOCc1ccccc1",
        "output": "126"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(C)=O.CCn1c(=O)c2c(C)n(C3CCCCO3)nc2c2cc(-c3ccc(C=O)s3)ccc21.ClCCCl.[Na+]>>CCn1c(=O)c2c(C)n(C3CCCCO3)nc2c2cc(-c3ccc(CN4CCCC4)s3)ccc21",
        "output": "792"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N(CC(=O)O)OC(C)(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.COc1ccc(Sc2ccc(CN3CCC(c4cc(N)ccc4C)CC3)cc2)cc1.Cl.ClCCl>>COc1ccc(Sc2ccc(CN3CCC(c4cc(NC(=O)CN(OC(C)(C)C)C(C)=O)ccc4C)CC3)cc2)cc1",
        "output": "365"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)[O-].COc1ccc(C(F)(F)F)cc1N.O.O=C(Cl)CCl.[Na+]>>COc1ccc(C(F)(F)F)cc1NC(=O)CCl",
        "output": "9"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cn1c(=O)c(C(=O)NCC(=O)OC(C)(C)C)c(O)c2cc(Cl)ncc21.O=C(O)C(F)(F)F>>Cn1c(=O)c(C(=O)NCC(=O)O)c(O)c2cc(Cl)ncc21",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNCC1.CCN(CC)C(=O)C(C)(C)Oc1ccc(-c2ccc(Br)cc2)cc1.CN(C)P(=O)(N(C)C)N(C)C.[H-].[Na+]>>CCN(CC)C(=O)C(C)(C)Oc1ccc(-c2ccc(N3CCCCC3)cc2)cc1",
        "output": "294"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.F[C@@H]1CCNC1.O=C(NCC1(O)CCCC(F)(F)C1)c1c(Cl)ccc2nc(Cl)ccc12>>O=C(NCC1(O)CCCC(F)(F)C1)c1c(Cl)ccc2nc(N3CC[C@@H](F)C3)ccc12",
        "output": "220"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCC(=O)Cl.CN1CCOCC1.ClCCl.NC1Cc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc2C1>>CCCC(=O)NC1Cc2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc2C1",
        "output": "45"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)N.CCN(CC)CC.CCOCC.CN(C)c1ccc(C(=O)Cl)cc1>>CC(C)NC(=O)c1ccc(N(C)C)cc1",
        "output": "271"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)OC(=O)OCC.NCc1cc(-c2ccc(OC(F)(F)F)cc2)nc(N2CCCC2)c1.O=C(O)C1(NS(=O)(=O)c2ccc(F)cc2)CC1>>O=C(NCc1cc(-c2ccc(OC(F)(F)F)cc2)nc(N2CCCC2)c1)C1(NS(=O)(=O)c2ccc(F)cc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOc1cc(Oc2ccc(NS(=O)(=O)c3ccc(C)cc3)c(C(=O)OC)c2)ccc1NS(=O)(=O)c1ccc(C)cc1.O>>CCOc1cc(Oc2ccc(NS(=O)(=O)c3ccc(C)cc3)c(C(=O)O)c2)ccc1NS(=O)(=O)c1ccc(C)cc1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)C(C)(C(=O)OC(C)(C)C)c1ccc(N)cc1.CCN=C=NCCCN(C)C.COC(=O)CCCCCCC(=O)[O-].ClCCl>>COC(=O)CCCCCCC(=O)Nc1ccc(C(C)(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1",
        "output": "891"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "B.COc1cc2c(C)nn(Cc3c(Cl)cccc3Cl)c2cc1C(=O)O.ClCCl.[Br-].[Br-].[Br-]>>Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(C(=O)O)c(O)cc12",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C.CO.Cc1ccc(O)c([N+](=O)[O-])n1>>Cc1ccc(O)c(N)n1",
        "output": "457"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=C(O)c1ccc(-c2nnn[nH]2)cc1F.O=S(Cl)Cl>>COC(=O)c1ccc(-c2nnn[nH]2)cc1F",
        "output": "33"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc(F)c(-n2cc(C#N)c(OC(F)(F)C(F)OC(F)(F)F)n2)cc1SCC(F)(F)F.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>Cc1cc(F)c(-n2cc(C#N)c(OC(F)(F)C(F)OC(F)(F)F)n2)cc1S(=O)CC(F)(F)F",
        "output": "500"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.O=S([O-])S(=O)(=O)[O-].O=c1[nH]ncc2ccc(O)cc12.[Na+].[Na+].[Na+].[OH-]>>O=c1[nH]ncc2cc(Br)c(O)cc12",
        "output": "98"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CN.CN(C)C=O.O=C(CCl)Nc1ccc2[nH]c(=O)c3ccccc3c2c1>>CNCC(=O)Nc1ccc2[nH]c(=O)c3ccccc3c2c1",
        "output": "330"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCCCCCc1ccc(O)c([N+](=O)[O-])c1.CCO.O=[Pt].[H][H]>>CCCCCCCCCCCCc1ccc(O)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)C1CN(Cc2cc3cc(Cl)ccc3n2C(=O)OC(C)(C)C)CC(=O)N1Cc1ccc2c(N)ncnc2c1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)C1CN(Cc2cc3cc(Cl)ccc3[nH]2)CC(=O)N1Cc1ccc2c(N)ncnc2c1",
        "output": "848"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N[C@@H](CCCCCBr)C(=O)O.CCN=C=NCCCN(C)C.CCOC(C)=O.Nc1ccccc1>>CC(C)(C)OC(=O)N[C@@H](CCCCCBr)C(=O)Nc1ccccc1",
        "output": "365"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCc1nc(C(=O)OCC)c(O)c2sc(-c3ccccc3)nc12.CO.C[O-].NCC(=O)O.[Na+]>>CCCc1nc(C(=O)NCC(=O)O)c(O)c2sc(-c3ccccc3)nc12",
        "output": "977"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1ccc(Br)nc1.ClCCl.Cl[Pd]Cl.OB(O)c1ccc(Cl)cc1.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COC(=O)c1ccc(-c2ccc(Cl)cc2)nc1",
        "output": "869"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C[C@H]1CN(Cc2ccc(Br)cc2)CCN1C(=O)OCc1ccccc1.O=C(OCc1ccccc1)N1CCNCC1.O=Cc1ccc(Br)cc1>>O=C(OCc1ccccc1)N1CCN(Cc2ccc(Br)cc2)CC1",
        "output": "567"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C)C=O.N#Cc1c(Oc2cc(N)c(F)cc2Cl)ccc2nc(NC(=O)C3CC3)sc12.O=C(Cl)C(=O)Cl.O=C(O)c1cccc(OC(F)(F)F)c1>>N#Cc1c(Oc2cc(NC(=O)c3cccc(OC(F)(F)F)c3)c(F)cc2Cl)ccc2nc(NC(=O)C3CC3)sc12",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1cnn(C)c1Cl.Cl.O.[K+].[OH-]>>Cn1ncc(C(=O)O)c1Cl",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc(-c2ccccc2-c2cccs2)cc1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>BrCc1ccc(-c2ccccc2-c2cccs2)cc1",
        "output": "29"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NCc1ccc(F)cc1.O=C(O)c1ccncc1Nc1ccc(I)cc1F>>O=C(NCc1ccc(F)cc1)c1ccncc1Nc1ccc(I)cc1F",
        "output": "753"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.Cc1ccc(OC(=O)Cl)cc1.Nc1nc(N2CCNCC2)c2nc(-c3cccnc3)sc2n1>>Cc1ccc(OC(=O)N2CCN(c3nc(N)nc4sc(-c5cccnc5)nc34)CC2)cc1",
        "output": "219"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cn(C(CC(C)C)C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)cc1-c1cc(Cl)ccc1OC(F)F.O=C(O)C(F)(F)F>>COc1cn(C(CC(C)C)C(=O)Nc2ccc(C(=O)O)cc2)c(=O)cc1-c1cc(Cl)ccc1OC(F)F",
        "output": "752"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=C(C)C(=O)Nc1cc(-c2ncnc3c2c(C(=O)OCC)cn3COCC[Si](C)(C)C)cc(OC)n1.ClCCl.O=C(O)C(F)(F)F>>C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OCC)c23)cc(OC)n1",
        "output": "897"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)CBr.O=C(c1ccc(O)c(Br)c1)c1cccs1>>CCOC(=O)COc1ccc(C(=O)c2cccs2)cc1Br",
        "output": "123"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=CC(=O)Cl.CCN(CC)CC.O.OCCCCC[C@@H]1CC[C@@H](c2cccc(F)c2F)CC1>>C=CC(=O)OCCCCC[C@@H]1CC[C@@H](c2cccc(F)c2F)CC1",
        "output": "320"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(N)cc4)nc32)CC1.O=C(Cl)Oc1ccccc1>>COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)Oc5ccccc5)cc4)nc32)CC1",
        "output": "102"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C=C(C#N)C(=O)O.ClCCl.F[P-](F)(F)(F)(F)F.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1F)nn2C1CNC1.c1cnc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CC(C)C=C(C#N)C(=O)N1CC(n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1",
        "output": "517"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Cn1[nH]c(=O)c2c1[C@]1(C)CC[C@H]2C1(C)C.FC(F)(F)c1cccc(CBr)c1>>Cn1c2c(c(=O)n1Cc1cccc(C(F)(F)F)c1)[C@H]1CC[C@]2(C)C1(C)C",
        "output": "635"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCC.C[Mg]Br.O=C1CCCc2ccccc21>>CC1(O)CCCc2ccccc21",
        "output": "586"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1c(C=O)c2cc(F)ccc2n1Cc1cccc2ccccc12.CNC(C)C>>CCOC(=O)c1c(CN(C)C(C)C)c2cc(F)ccc2n1Cc1cccc2ccccc12",
        "output": "757"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)c1ccncc1.CS(=O)(=O)Cl.Cl.NC(=O)c1cc(-c2ccccc2)cc2c(C3CCNCC3)n[nH]c12>>CS(=O)(=O)N1CCC(c2n[nH]c3c(C(N)=O)cc(-c4ccccc4)cc23)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CCOC(C)=O.CS(C)=O.O=C([O-])[O-].O=[N+]([O-])c1c(F)cc(F)cc1F.[K+].[K+]>>O=[N+]([O-])c1c(F)cc(N2CCOCC2)cc1F",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#Cc1cnn2c(C(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12.O=S(=O)(NCCO)c1cccc(Br)c1>>O=S(=O)(NCCO)c1cccc(C#Cc2cnn3c(C(F)F)cc(-c4ccc(C(F)(F)F)cc4)nc23)c1",
        "output": "659"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COc1ccc2c(Cl)ncc(C(=O)O)c2c1.C[Si](C)(C)C=[N+]=[N-]>>COC(=O)c1cnc(Cl)c2ccc(OC)cc12",
        "output": "195"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)c1c(C)nn(-c2ccc(F)cc2)c1C.O.[Na+].[OH-]>>Cc1nn(-c2ccc(F)cc2)c(C)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CN1CCN(CCCNC(=O)OC(C)(C)C)C1=O.Cl>>CN1CCN(CCCN)C1=O",
        "output": "538"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1ccc(C(=O)Nc2nccs2)cc1.[Na+].[OH-]>>O=C(O)c1ccc(C(=O)Nc2nccs2)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(=O)/N=N/C(=O)OCC.CCOC(C)=O.COc1cc(OC)c2cnc(-c3cc(C)c(O)c(C)c3)cc2c1.OCCN1CCOCC1>>COc1cc(OC)c2cnc(-c3cc(C)c(OCCN4CCOCC4)c(C)c3)cc2c1",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COCC(=O)Cl.Cl.O=C(N[C@H]1CCNC1)c1c[nH]c2c(-c3c(OCC4CC4)ccc4c3OCO4)ncnc12>>COCC(=O)N1CC[C@H](NC(=O)c2c[nH]c3c(-c4c(OCC5CC5)ccc5c4OCO5)ncnc23)C1",
        "output": "125"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCc2sc(C=O)cc2C1.N[C@H]1CCN(S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1>>CC(C)(C)OC(=O)N1CCc2sc(CN[C@H]3CCN(S(=O)(=O)c4ccc5cc(Cl)ccc5c4)C3)cc2C1",
        "output": "691"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1.Cl>>O=S(=O)(NC1CCNCC1)c1cc(S(=O)(=O)c2ccccc2)ccc1C(F)(F)F",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COc1c(C(C)=O)ccc(OCCCOc2cccc([N+](=O)[O-])c2)c1CCC(F)(F)F.[Ni]>>COc1c(C(C)=O)ccc(OCCCOc2cccc(N)c2)c1CCC(F)(F)F",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)c1cc(Nc2nc(N3CCCC3C(=O)O)nc3c2CCC3)n[nH]1.CCN(C(C)C)C(C)C.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O>>CNC(=O)C1CCCN1c1nc2c(c(Nc3cc(C(C)C)[nH]n3)n1)CCC2",
        "output": "216"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.COC(=O)CCOCCOCCOCCOCCN(C)C(=O)OC(C)(C)C.Cl>>CNCCOCCOCCOCCOCCC(=O)OC",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(CCCCl)OCCO1.CN(C)C=O.O=Cc1c[nH]c2ccccc12.[H-].[Na+]>>CC1(CCCn2cc(C=O)c3ccccc32)OCCO1",
        "output": "42"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)[O-].CN(C)C=O.Cl.O=C(O)c1ccc(Br)c(Cl)n1.OCC(F)(F)C(F)(F)F.[K+]>>O=C(O)c1ccc(Br)c(OCC(F)(F)C(F)(F)F)n1",
        "output": "433"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)COc1ccc2nc(Cl)c(C(=O)O)cc2c1.CC(C)n1ncc2c1C(=O)CC1(CCNCC1)C2>>CC(C)n1ncc2c1C(=O)CC1(CCN(C(=O)c3cc4cc(OCC(=O)OC(C)(C)C)ccc4nc3Cl)CC1)C2",
        "output": "256"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)C(=O)Nc1ccc(F)c([N+](=O)[O-])c1.CCN(CC)CC.CCO.NCC1CCCCC1>>CC(C)(C)C(=O)Nc1ccc(NCC2CCCCC2)c([N+](=O)[O-])c1",
        "output": "572"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)CNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21.CO.[Na+].[OH-]>>O=C(O)CNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N[C@@H](Cc1cc(F)cc(F)c1)c1ncc(Br)cc1Br.O=C(O)Cn1nc(C(F)F)c2c1C(F)(F)CCC2(F)F>>O=C(Cn1nc(C(F)F)c2c1C(F)(F)CCC2(F)F)N[C@@H](Cc1cc(F)cc(F)c1)c1ncc(Br)cc1Br",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)COC(=O)Cl.CCN(CC)CC.CN1CCOCC1.COc1cc(N)c(Cl)cc1C(=O)O.ClCCl.NCC1CCN(CCCn2ccnn2)CC1.O.O=C(O)[C@H](O)[C@@H](O)C(=O)O>>COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccnn2)CC1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br.Cc1nc(C(C)(N)CS(C)(=O)=O)no1.Cl.O=C(O)c1cc(OCC(F)F)c(C2CC2)cn1>>Cc1nc(C(C)(CS(C)(=O)=O)NC(=O)c2cc(OCC(F)F)c(C3CC3)cn2)no1",
        "output": "137"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.ClCCCBr.O=C(NC1CCNCC1)c1ccccc1>>O=C(NC1CCN(CCCCl)CC1)c1ccccc1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCc1cc(CCC=O)n(-c2ccccc2)n1.CCN(C(C)C)C(C)C.[Na+].c1ccc(N2CCNCC2)cc1>>CCCc1cc(CCCN2CCN(c3ccccc3)CC2)n(-c2ccccc2)n1",
        "output": "484"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)C1CN(S(=O)(=O)c2ccccc2)C(=O)N1c1ccccc1Cl.[Na+].[OH-]>>O=C(O)C1CN(S(=O)(=O)c2ccccc2)C(=O)N1c1ccccc1Cl",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)SCC(C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C)C(F)(F)F.COc1ccccc1.O=C(O)C(F)(F)F>>CC(=O)SCC(C(=O)N1CCC[C@H]1C(=O)O)C(F)(F)F",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)[C@@H](CC(C)(C)C)NC(=O)OC(C)(C)C.Cl.O.O.[Cl-].[Li+].[Na+].[OH-]>>CC(C)(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCC1CCCCC1.CCCc1cc(C(=O)OC)ccc1O.CN(C)C=O.O=C([O-])[O-].[Cs+].[Cs+]>>CCCc1cc(C(=O)OC)ccc1OCC1CCCCC1",
        "output": "385"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CO.O=C(NCc1ccccc1)c1cc2c(NCc3ccccc3)ncnc2n(OCc2ccccc2)c1=O.[C].[H][H].[OH-].[OH-].[Pd+2]>>O=C(NCc1ccccc1)c1cc2c(NCc3ccccc3)ncnc2n(O)c1=O",
        "output": "630"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC[C@H](C)Nc1cnc(-c2ccc(C(C)C)nc2OC)c(C)c1C.ClC(Cl)Cl.O.O=C1CCC(=O)N1Br>>COC[C@H](C)Nc1c(Br)nc(-c2ccc(C(C)C)nc2OC)c(C)c1C",
        "output": "779"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.OCCc1coc(-c2cccs2)n1.Oc1ccc(CCCn2ccnc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>c1csc(-c2nc(CCOc3ccc(CCCn4ccnc4)cc3)co2)c1",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CC(C)(C)[Si](C)(C)Oc1cccc2c1nc(C(F)F)n2-c1nc(Cl)cc(N2CCCC2CO)n1.O>>CC(C)(C)[Si](C)(C)Oc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)cc(N2CCCC2CO)n1",
        "output": "296"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C(O)c1cn(CCO)c2c(F)c(F)c(F)cc2c1=O.c1cn2c(n1)CNCC2>>O=C(O)c1cn(CCO)c2c(F)c(N3CCn4ccnc4C3)c(F)cc2c1=O",
        "output": "676"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1cc2c(ncn2-c2cccc(-c3ccsc3)c2)[nH]1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1cc2c(ncn2-c2cccc(-c3ccsc3)c2)[nH]1",
        "output": "711"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClC(Cl)(Cl)Cl.Nc1ccc2ccccc2c1.O=C1CCC(=O)N1Cl>>Nc1ccc2ccccc2c1Cl",
        "output": "121"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)C1SCC(=O)c2cc(C3CCCCC3)ccc21.CO.O.[K+].[OH-]>>O=C1CSC(C(=O)O)c2ccc(C3CCCCC3)cc21",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)c1cc2ccc(Br)cc2cc1CO.CS(C)=O.O>>CN(C)c1cc2ccc(Br)cc2cc1C=O",
        "output": "179"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccccc1.O=C(c1ccccc1)c1ccc(Cl)c([N+](=O)[O-])c1.[Cl-].[Fe].[NH4+]>>Nc1cc(C(=O)c2ccccc2)ccc1Cl",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrC(Br)(Br)Br.C1CCOC1.CC(O)(CCO)CCOC(=O)c1ccccc1.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(O)(CCBr)CCOC(=O)c1ccccc1",
        "output": "378"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.Cc1c(CN2CCN[C@@H](C)C2)cc(F)cc1[N+](=O)[O-].ClCCl.O=C(Cl)c1cccc(F)c1>>Cc1c(CN2CCN(C(=O)c3cccc(F)c3)[C@@H](C)C2)cc(F)cc1[N+](=O)[O-]",
        "output": "201"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.C[C@H](N)CO.O.O=C(O)c1c[nH]c2ncc(-c3n[nH]c4cc(Cl)ccc34)nc12.On1nnc2ccccc21>>C[C@@H](CO)NC(=O)c1c[nH]c2ncc(-c3n[nH]c4cc(Cl)ccc34)nc12",
        "output": "737"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)Cc1ccccc1CCc1nc(Nc2ccc(C(C)NC(=O)OC(C)(C)C)cc2)ncc1C(F)(F)F.O.[Li+].[OH-]>>CC(NC(=O)OC(C)(C)C)c1ccc(Nc2ncc(C(F)(F)F)c(CCc3ccccc3CC(=O)O)n2)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#CCBr.CN(C)C=O.O.O=[N+]([O-])c1cc2cnn(-c3c(Cl)cc(C(F)(F)F)cc3Cl)c2cc1O.[H-].[Na+]>>C#CCOc1cc2c(cnn2-c2c(Cl)cc(C(F)(F)F)cc2Cl)cc1[N+](=O)[O-]",
        "output": "154"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.Cc1cc(C)c(O)c(C)c1.Cc1nc(Cl)c(C)c(Cl)n1.[H-].[Na+]>>Cc1cc(C)c(Oc2nc(C)nc(Cl)c2C)c(C)c1",
        "output": "890"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)[O-].CI.OCCCC(F)(F)COCc1ccccc1.[K+]>>COCCCC(F)(F)COCc1ccccc1",
        "output": "140"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COC(=O)C(=O)c1ccc(O)cc1.CS(=O)(=O)[O-].OCCSc1ccc2ccccc2c1.[H-].[Na+]>>COC(=O)C(=O)c1ccc(OCCSc2ccc3ccccc3c2)cc1",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)c1ccc(-c2cn[nH]c(=O)c2Oc2ccc(F)cc2)cc1.Fc1ccc(Br)cc1F.N>>CS(=O)(=O)c1ccc(-c2cnn(-c3ccc(F)c(F)c3)c(=O)c2Oc2ccc(F)cc2)cc1",
        "output": "919"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)c1ccncc1.CN1CCOCC1.COC(=O)[C@@H](N)CCSC.Cl.ClCCCl.ClCCl.O=C(O)c1cc(/C=C(/Cn2ccnc2)c2ccc(F)cc2)ccc1CCc1ccc(F)cc1.On1nnc2ccccc21>>COC(=O)[C@H](CCSC)NC(=O)c1cc(/C=C(/Cn2ccnc2)c2ccc(F)cc2)ccc1CCc1ccc(F)cc1",
        "output": "652"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNC.COC(C(=O)Cl)c1ccccn1.COC(C(=O)O)c1ccccn1.Cl.ClC(Cl)Cl.O=S(Cl)Cl.[Na+].[OH-].c1ccccc1>>COC(C(=O)N(C)C)c1ccccn1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1cnc2[nH]ncc2c1N1CCNCC1.CC(C)(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cl.Cl.ClCCl.F[B-](F)(F)F>>CC(C)(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2c(Br)cnc3[nH]ncc23)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCC.CCOCC.CI.CN(C)C=O.Cl.[H-].[K+].c1ccc(-c2nn3c(c2-c2ccnc4[nH]ccc24)CCC3)nc1>>Cn1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc21",
        "output": "570"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.Nc1cc(Cl)ccn1.O=C1CCC(=O)N1Cl>>Nc1cc(Cl)c(Cl)cn1",
        "output": "743"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](F)[C@H]1C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.NCc1cccc(Cl)c1F>>CC(C)(C)OC(=O)N1CC[C@H](F)[C@H]1C(=O)NCc1cccc(Cl)c1F",
        "output": "797"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCCOc1ccccc1.CCCCCCCc1ccccc1.O=C1CCC(=O)O1>>CCCCCCCc1ccc(C(=O)CCC(=O)O)cc1",
        "output": "345"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.N#Cc1ccccc1F.O=C([O-])[O-].OC1CCCN1.[Na+].[Na+]>>N#Cc1ccccc1N1CCCC1O",
        "output": "26"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)n1ncc(-c2nc(CC(=O)O)cs2)c1Br.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCC1CCOCC1.O>>CC(C)(C)n1ncc(-c2nc(CC(=O)NCC3CCOCC3)cs2)c1Br",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.Nc1cn2nc(Cl)ccc2n1.O.O=C(Cl)CBr>>O=C(CBr)Nc1cn2nc(Cl)ccc2n1",
        "output": "399"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.CCN(CC)CC.CN1CCN(CCN)CC1.CO.Nc1ncc(Br)cc1C=O.[BH4-].[Na+]>>CN1CCN(CCNCc2cc(Br)cnc2N)CC1",
        "output": "441"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.Cn1c(C(F)(F)F)cc(=O)n(-c2c(N)cc(Cl)cc2F)c1=O.O.O=C(Cl)c1ccc2ccccc2c1>>Cn1c(C(F)(F)F)cc(=O)n(-c2c(F)cc(Cl)cc2NC(=O)c2ccc3ccccc3c2)c1=O",
        "output": "11"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.CC[C@@H]([C@H](C)OCc1ccccc1)n1ncn(-c2ccc(N3CCN(c4ccc(O)cc4)CC3)cc2)c1=O.CS(C)=O.Cc1ccc(S(=O)(=O)OC[C@@H]2CO[C@@](Cn3cncn3)(c3ccc(F)cc3F)C2)cc1.O.[Na+].[OH-]>>CC[C@@H]([C@H](C)OCc1ccccc1)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@@H]5CO[C@@](Cn6cncn6)(c6ccc(F)cc6F)C5)cc4)CC3)cc2)c1=O",
        "output": "438"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)CCN.CCN(C(C)C)C(C)C.CO.Cl.O.O=Cc1ccc(C(=O)O)cc1.[BH3-]C#N.[Na+]>>CC(C)(C)OC(=O)CCNCc1ccc(C(=O)O)cc1",
        "output": "468"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O=C(O)CCc1ccc(O)cc1.O=C([O-])O.[Na+].c1ccc2c(c1)CCNC2>>O=C(CCc1ccc(O)cc1)N1CCc2ccccc2C1",
        "output": "633"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NCCc1ccccc1.O=C(O)c1ccccc1-c1ccccc1CN1C(=O)c2ccccc2C1=O.O=C(n1ccnc1)n1ccnc1>>O=C(NCCc1ccccc1)c1ccccc1-c1ccccc1CN1C(=O)c2ccccc2C1=O",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCC(=O)c1ccc(-c2ccc(OC)c(Cl)c2)cc1.CCCCCCCCO.COc1ccc(-c2ccccc2)cc1Cl.Oc1ccc(-c2ccccc2)cc1Cl.S=C=S.[Cl-].[Cl-].[NH4+]>>CCCCCCCCc1ccc(-c2ccc(OC)c(Cl)c2)cc1",
        "output": "92"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.CCCC[N+](CCCC)(CCCC)CCCC.COc1cccc(C(=O)c2cc(C#N)c3ccc4ccccc4n23)c1.ClCCl.[Br-].[I-].[K+]>>N#Cc1cc(C(=O)c2cccc(O)c2)n2c1ccc1ccccc12",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCn1nc(C)cc1Nc1cc(Nc2ccccc2C(=O)O)c(Cl)cn1.CN(C)C=O.CNO.ClCCCl.On1nnc2ccccc21>>CCn1nc(C)cc1Nc1cc(Nc2ccccc2C(=O)N(C)O)c(Cl)cn1",
        "output": "828"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "FC(F)(F)c1ccc(N2CCNCC2)nc1.O=C(NCC(F)(F)F)C1(CCCCBr)c2ccccc2-c2ccccc21>>O=C(NCC(F)(F)F)C1(CCCCN2CCN(c3ccc(C(F)(F)F)cn3)CC2)c2ccccc2-c2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.C[Si](C)(C)CCS(N)(=O)=O.ClCCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1cc(C2CC2)c(OCC2CN(C(c3ccccc3)c3ccccc3)C2)cc1F>>C[Si](C)(C)CCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CN(C(c3ccccc3)c3ccccc3)C2)cc1F",
        "output": "580"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.NCC1CCCc2cc(OCC(N)=O)ccc21.O=S(=O)(Cl)c1ccc(Cl)cc1>>NC(=O)COc1ccc2c(c1)CCCC2CNS(=O)(=O)c1ccc(Cl)cc1",
        "output": "43"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CN1CCN(c2cccc3c2C[C@H](N)CC3)CC1.O=C(O)c1ccc(N2CCOCC2)cc1.O=C(n1ccnc1)n1ccnc1.O=C=O>>CN1CCN(c2cccc3c2C[C@H](NC(=O)c2ccc(N4CCOCC4)cc2)CC3)CC1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)CCSc1cc2cc(Cl)ccc2[nH]1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1>>CC(C)(C)OC(=O)CCSc1cc2cc(Cl)ccc2n1C(=O)OC(C)(C)C",
        "output": "748"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cc1nc2cccc3n(CCCCCCN4C(=O)c5ccccc5C4=O)c(=O)c1n23.NN>>Cc1nc2cccc3n(CCCCCCN)c(=O)c1n23",
        "output": "242"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Clc1ccc(OCCCI)cc1.O=C1C(=O)c2ccccc2C2=C1SCC1(CCNCC1)O2>>O=C1C(=O)c2ccccc2C2=C1SCC1(CCN(CCCOc3ccc(Cl)cc3)CC1)O2",
        "output": "184"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1c(Br)sc2ncnc(Nc3ccc(F)cc3OC(C)CN)c12.ClCCl>>Cc1c(Br)sc2ncnc(Nc3ccc(F)cc3OC(C)CNS(C)(=O)=O)c12",
        "output": "493"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(Cl)Cl.Sc1ccccc1>>O=Cc1ccc(S)cc1",
        "output": "591"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1ccc(C(=O)c2ccc(Cl)nc2)c(OCc2ccccc2)c1.Cc1oc(-c2ccccc2)nc1CCO.[Cl-].[H-].[NH4+].[Na+]>>COc1ccc(C(=O)c2ccc(OCCc3nc(-c4ccccc4)oc3C)nc2)c(OCc2ccccc2)c1",
        "output": "433"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCC(Oc1cc(C)c(-n2cc(C(F)(F)F)cn2)c(C)c1)c1ccc(C(=O)OCC)cc1.CO.O.O.[Li+].[OH-]>>CCCC(Oc1cc(C)c(-n2cc(C(F)(F)F)cn2)c(C)c1)c1ccc(C(=O)O)cc1",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCN1.CS(C)=O.O.O=C([O-])[O-].O=C(c1ccc(F)cc1)c1ccc([N+](=O)[O-])cc1.[K+].[K+]>>O=C(c1ccc(N2CCOCC2)cc1)c1ccc([N+](=O)[O-])cc1",
        "output": "26"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCO.COc1cc(OC)cc(-c2c(-c3ccc(F)cc3)c(C)nc(Cl)c2C2CCCC2)c1.[H][H].[Pd]>>COc1cc(OC)cc(-c2c(C3CCCC3)cnc(C)c2-c2ccc(F)cc2)c1",
        "output": "40"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc(C=O)ccc1Oc1ccc(C(N)=O)cn1.NCCN1CCOCC1>>COc1cc(CNCCN2CCOCC2)ccc1Oc1ccc(C(N)=O)cn1",
        "output": "468"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)[Mg]Cl.CN(C)C=O.Fc1cc(Br)cc(Br)c1>>O=Cc1cc(F)cc(Br)c1",
        "output": "638"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=Cc1ccccc1F.OCc1cccc(-c2nc(N3CCOCC3)c3ncn(C4CCNCC4)c3n2)c1.[BH3-]C#N.[Cl-].[Cl-].[Na+].[Zn+2]>>OCc1cccc(-c2nc(N3CCOCC3)c3ncn(C4CCN(Cc5ccccc5F)CC4)c3n2)c1",
        "output": "567"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.ClCCl.Nc1ccc(-c2cccc(Br)c2)c(C(F)(F)F)c1.O=C(O)Cc1ccc(-n2cnc3cccnc32)cc1>>O=C(Cc1ccc(-n2cnc3cccnc32)cc1)Nc1ccc(-c2cccc(Br)c2)c(C(F)(F)F)c1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCO.Cc1ccccc1.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.Nc1ccc(Br)cc1.O.O=C([O-])[O-].OB(O)c1cccc2ccccc12.[K+].[K+].[Pd+2]>>Nc1ccc(-c2cccc3ccccc23)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCC(=O)Cl.CCCCCCC.Clc1ccccc1Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>CCCCC(=O)c1ccc(Cl)c(Cl)c1",
        "output": "31"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(Nc1cncc(Br)c1)c1ccnc(Nc2cccc(C(F)(F)F)n2)c1.O=C([O-])[O-].OB(O)c1ccccc1.[Na+].[Na+]>>O=C(Nc1cncc(-c2ccccc2)c1)c1ccnc(Nc2cccc(C(F)(F)F)n2)c1",
        "output": "833"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CCn1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2c1c(=O)n(C)c(=O)n2C.ClCCl.O=C(O)C(F)(F)F>>C=CCn1c(N2CCNCC2)nc2c1c(=O)n(C)c(=O)n2C",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1=COCCC1.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O=[N+]([O-])c1ccc2[nH]ncc2c1.[Na+].[OH-]>>O=[N+]([O-])c1ccc2c(cnn2C2CCCCO2)c1",
        "output": "878"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.CN(C)C=O.CSc1nc(Cl)cc(-n2c(C(F)F)nc3ccccc32)n1.O.O=C([O-])[O-].[K+].[K+]>>CSc1nc(N2CCOCC2)cc(-n2c(C(F)F)nc3ccccc32)n1",
        "output": "296"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)O.CCO.CCOC(=O)CCCN(CCCO)c1ccc(N=Nc2ccc([N+](=O)[O-])cc2Cl)cc1.O.[K+].[OH-]>>O=C(O)CCCN(CCCO)c1ccc(N=Nc2ccc([N+](=O)[O-])cc2Cl)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CC1(CN)CC2CC=CC21.CCOC(C)=O.Cl>>NCC1(CC(=O)O)CC2CC=CC21",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(C=O)ccc1O.NC12CC3CC(CC(C3)C1)C2>>Cc1cc(CNC23CC4CC(CC(C4)C2)C3)ccc1O",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.COC(=O)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl.[Na+].[OH-]>>O=C(O)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COc1cc2ncnc(Nc3nc4ccc(N)cc4s3)c2cc1OC.ClCCl.O=C=Nc1ccc(Cl)cc1>>COc1cc2ncnc(Nc3nc4ccc(NC(=O)Nc5ccc(Cl)cc5)cc4s3)c2cc1OC",
        "output": "473"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(NC(=O)OC(C)(C)C)CCNCC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[P-](F)(F)(F)(F)F.N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)O)cc4)nn23)cc1.O>>CC1(NC(=O)OC(C)(C)C)CCN(C(=O)c2ccc(-c3ccc4ncc(-c5ccc(C#N)cc5)n4n3)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(C)=O.COC(=O)CC(=O)Nc1cc(C)c(Oc2ccc(O)c(C(=O)c3ccc(F)cc3)c2)c(C)c1.[Ni]>>COC(=O)CC(=O)Nc1cc(C)c(Oc2ccc(O)c(C(O)c3ccc(F)cc3)c2)c(C)c1",
        "output": "157"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=Cc1ccc(O)cc1.O=Cc1ccccc1.[H][H]>>OCc1ccc(O)cc1",
        "output": "356"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Nc1ccc2ncccc2c1.O=C(O)c1cc([N+](=O)[O-])c(Sc2c(Cl)cncc2Cl)s1>>O=C(Nc1ccc2ncccc2c1)c1cc([N+](=O)[O-])c(Sc2c(Cl)cncc2Cl)s1",
        "output": "822"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.CCc1nc2ccc(-n3ccc(O)cc3=O)cc2n1C.O.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.OCc1ccc(Cl)c(F)c1>>CCc1nc2ccc(-n3ccc(OCc4ccc(Cl)c(F)c4)cc3=O)cc2n1C",
        "output": "347"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=C(C)CCl.CC(C)(C)OC(=O)Nc1cc([N+](=O)[O-])ccc1O.CC(C)=O.O=C([O-])[O-].[K+].[K+]>>C=C(C)COc1ccc([N+](=O)[O-])cc1NC(=O)OC(C)(C)C",
        "output": "119"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCOC(=O)c1cn(CC)c2sc(C)cc2c1=O.[Na+].[OH-]>>CCn1cc(C(=O)O)c(=O)c2cc(C)sc21",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=[N+]([O-])c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1.[Na]>>COc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1",
        "output": "499"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CO.Cc1cc2oc(=O)c3c(c2cc1[N+](=O)[O-])CCNC3.[H][H].[Ni]>>Cc1cc2oc(=O)c3c(c2cc1N)CCNC3",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.N#CCCCCCOc1ccc2nc(-c3ccccc3)n(-c3ccccc3)c2c1.O=C([O-])[O-].OO.[K+].[K+]>>NC(=O)CCCCCOc1ccc2nc(-c3ccccc3)n(-c3ccccc3)c2c1",
        "output": "632"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.O=P(Cl)(Cl)Cl.Oc1nc2ncccc2cc1C1CC1>>Clc1nc2ncccc2cc1C1CC1",
        "output": "41"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CCC(C)=O.O=C([O-])[O-].Oc1ccc(F)c(F)c1.[K+].[K+]>>Fc1ccc(OCc2ccccc2)cc1F",
        "output": "127"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)C.CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].CCC(C)(C)O.COC(=O)C[C@@H](O)CC(N)=O.COC(C)(C)C.N.O=C(O)C(O)C(O)C(=O)O.OCc1ccccc1.[Ti+4]>>NC(=O)C[C@H](O)CC(=O)OCc1ccccc1",
        "output": "289"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)c1ccc(CS(N)(=O)=O)c(Cl)c1.OCc1ccccc1.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[Li+].[NH4+]>>NS(=O)(=O)Cc1ccc(CO)cc1Cl",
        "output": "444"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.C[O-].O=C(c1ccc(Cl)nc1)c1cn(Cc2cccc(Br)n2)c2ccccc2c1=O.[Na+]>>COc1ccc(C(=O)c2cn(Cc3cccc(Br)n3)c3ccccc3c2=O)cn1",
        "output": "433"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCOC(c2ccc(NC(=O)Nc3cccc(C#N)c3)c(Cl)c2)C1.O.O=C(O)C(F)(F)F.[Na+].[OH-]>>N#Cc1cccc(NC(=O)Nc2ccc(C3CNCCO3)cc2Cl)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CO.NC1CCCCC1.O=C(O)CCC(=O)c1ccc(-c2ccc(F)cc2Cl)cc1>>O=C(O)CCCc1ccc(-c2ccc(F)cc2Cl)cc1",
        "output": "92"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.CS(C)=O.O=C(NC1CCNCC1)c1n[nH]c2ccccc12>>CS(=O)(=O)N1CCC(NC(=O)c2n[nH]c3ccccc23)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)CC(O)CC(C)(C)N1CC(F)(F)F.ClCCl.O=C([O-])O.[Na+]>>CC1(C)CC(=O)CC(C)(C)N1CC(F)(F)F",
        "output": "87"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)I.CN(C)C=O.COC(=O)c1cccc(-c2c(F)cc(O)cc2F)n1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cccc(-c2c(F)cc(OC(C)C)cc2F)n1",
        "output": "318"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1cc(Cl)ccc1O.[K+].[K+]>>O=[N+]([O-])c1cc(Cl)ccc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)N=C=O.Cc1nc2ccc(N)cc2s1.c1ccncc1>>Cc1nc2ccc(NC(=O)NC(C)(C)C)cc2s1",
        "output": "176"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.NCc1ccccc1OC(F)F.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Br)cc1F.[K+].[K+]>>O=[N+]([O-])c1ccc(Br)cc1NCc1ccccc1OC(F)F",
        "output": "764"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NC1CNc2ccccc2NC1=O.Cc1ccc2c(c1)NC(=O)C(NC(=O)OC(C)(C)C)CN2.O=C(Cl)C1CCCC1>>Cc1ccc2c(c1)NC(=O)C(NC(=O)OC(C)(C)C)CN2C(=O)C1CCCC1",
        "output": "160"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#CC1(N)CCSCC1>>CC(C)(C)OC(=O)NC1(C#N)CCSCC1",
        "output": "631"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCC(N2CCNCC2)CC1.CCCCOc1nc(N)c2nc(OC)n(CCCCl)c2n1.CCCCOc1nc(N)c2nc(OC)n(CCCN3CCN(CC)CC3)c2n1>>CCCCOc1nc(N)c2nc(OC)n(CCCN3CCN(C4CCCCC4)CC3)c2n1",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)Cn1nc(I)c2cccnc21.CO.[Li+].[OH-]>>O=C(O)Cn1nc(I)c2cccnc21",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(CN2CCC(CO)CC2)cc1.N#Cc1c(N)cccc1F>>COc1ccc(CN2CCC(COc3cccc(N)c3C#N)CC2)cc1",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCS(=O)(=O)c1cnc(NS(=O)(=O)Cc2cc(Cl)cc(Cl)c2)c(OC)c1.COc1cc(Cl)nnc1NS(=O)(=O)Cc1cc(C#N)ccc1Cl.N#Cc1ccc(Cl)c(CS(=O)(=O)Nc2nnc(Cl)cc2O)c1>>CCS(=O)(=O)c1cnc(NS(=O)(=O)Cc2cc(Cl)cc(Cl)c2)c(O)c1",
        "output": "424"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCOC(=O)CCCCCBr.Nc1ccc2ccc3cccc4ccc1c2c34.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CCCCCNc1ccc2ccc3cccc4ccc1c2c34",
        "output": "273"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(C(F)(F)F)cc1NC(=O)CC(=O)c1cccc(-c2ccc(C3CC3)nc2)c1.ClCCl.O=C(O)C(F)(F)F>>O=C1CC(c2cccc(-c3ccc(C4CC4)nc3)c2)=Nc2ccc(C(F)(F)F)cc2N1",
        "output": "930"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(C)=O.Cc1nn(-c2cncc(F)c2)cc1[N+](=O)[O-].[Pd]>>Cc1nn(-c2cncc(F)c2)cc1N",
        "output": "628"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.CCN(CC)CC.Cl.Cn1cc(Nc2nccc(N3C[C@H]4CC[C@@H](C3)N4)n2)cn1.N#Cc1ccnc(Cl)c1>>Cn1cc(Nc2nccc(N3C[C@H]4CC[C@@H](C3)N4c3cc(C#N)ccn3)n2)cn1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCCCCO.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>C=CCCCCOC(=O)c1ccc([N+](=O)[O-])cc1",
        "output": "51"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.Cc1cccc(-c2cc(Cl)nc(N)n2)c1C.NC1CC1c1ccc(Cl)cc1>>Cc1cccc(-c2cc(NC3CC3c3ccc(Cl)cc3)nc(N)n2)c1C",
        "output": "166"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Cc1c(C=CCCCC(=O)O)cccc1C(=O)c1ccc(Cl)cc1.O=[Pt].[H][H]>>Cc1c(CCCCCC(=O)O)cccc1C(=O)c1ccc(Cl)cc1",
        "output": "362"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC.CCOCC.CO.O.O=C(O)C(O)c1ccc(Cl)cc1.O=C([O-])[O-].O=S(=O)(O)O.[Na+].[Na+]>>COC(=O)C(O)c1ccc(Cl)cc1",
        "output": "195"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NC(C)(C)C(=O)Nc1ccc(Oc2cccc3c2C2(CC2)CO3)nc1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CC(C)(N)C(=O)Nc1ccc(Oc2cccc3c2C2(CC2)CO3)nc1",
        "output": "431"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(/C=C/c2nc(-c3ccc(Cl)cc3Cl)cn2CC(=O)O)cc1.COc1ccc(CCN)cc1OC>>COc1ccc(/C=C/c2nc(-c3ccc(Cl)cc3Cl)cn2CC(=O)NCCc2ccc(OC)c(OC)c2)cc1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.O=C1CCC(=O)N1Br.OCc1cn2ccnc(N3CCOCC3)c2n1>>OCc1cn2c(Br)cnc(N3CCOCC3)c2n1",
        "output": "665"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cl.ClC(Cl)C(Cl)Cl.N#Cc1ccc(O)cc1.O=C1CCC(=O)O1.[Al+3].[Cl-].[Cl-].[Cl-]>>N#Cc1ccc(O)c(C(=O)CCC(=O)O)c1",
        "output": "345"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=CCBr.C[C@@H](O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.[H-].[Na+]>>C=CCO[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "120"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CN(CC2(c3ccccc3)CCNCC2)CC(C)N1.CN(C)c1ccncc1.ClCCCl.ClCCl.O=C(O)CC(c1ccccc1)c1ccccc1>>CC1CN(CC2(c3ccccc3)CCN(C(=O)CC(c3ccccc3)c3ccccc3)CC2)CC(C)N1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.C[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)OCc1ccccc1.O.[Pd]>>C[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)O",
        "output": "186"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3ccc(C(F)(F)F)c4CN3CCOCC3)ccc21.[Na+].[OH-]>>O=C(O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3ccc(C(F)(F)F)c4CN3CCOCC3)ccc21",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N1CC2CN(C(=O)c3ccccc3-c3nnc[nH]3)CC2C1.CC(C)(C)OC(=O)N1CC2CNCC2C1.Cc1cc(C)nc(N2CC3CNCC3C2)n1.O=C(O)c1ccccc1-c1cn(Cc2ccccc2)nn1.O=C(O)c1ccccc1-c1nnc[nH]1>>Cc1cc(C)nc(N2CC3CN(C(=O)c4ccccc4-c4cn(Cc5ccccc5)nn4)CC3C2)n1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=P(Cl)(Cl)Cl.O=c1cc(-c2ccc(OC3CCCCC3)cc2)c(C2CC2)n[nH]1>>Clc1cc(-c2ccc(OC3CCCCC3)cc2)c(C2CC2)nn1",
        "output": "537"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCC(=O)O.CN(C)C=O.O=C1CCC(=O)N1O>>CCCCCC(=O)ON1C(=O)CCC1=O",
        "output": "303"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cl.NO.O=C([O-])[O-].O=Cc1ccccc1.[Na+].[Na+]>>ON=Cc1ccccc1",
        "output": "30"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)c1cc(-c2cncs2)ccc1Cl.Cl.[Na+].[OH-]>>O=C(O)c1cc(-c2cncs2)ccc1Cl",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCCCCCC(C)=O.Cc1ccc(S(=O)(=O)O)cc1.O.O.OCCO.c1ccccc1>>C=CCCCCCC1(C)OCCO1",
        "output": "265"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)CCc1nc(Cc2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)sc1-c1ccccc1.Cl.O.O.[Li+].[OH-]>>Cc1oc(-c2ccccc2)nc1COc1ccc(Cc2nc(CCC(=O)O)c(-c3ccccc3)s2)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.N#Cc1ccc(Cl)nc1OCCOC1CCCCO1.O=C([O-])[O-].O=Cc1cc(O)ccc1Br.[K+].[K+]>>N#Cc1ccc(Oc2ccc(Br)c(C=O)c2)nc1OCCOC1CCCCO1",
        "output": "516"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.O=C(O)Cc1c(F)cc(Br)cc1F.O=S(Cl)Cl>>O=C(Cl)Cc1c(F)cc(Br)cc1F",
        "output": "53"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=Cc1cc2c(cc1-c1cnn(C)c1)CCCN2c1nn(C2CCOCC2)c2c1CN(C(=O)NC)CC2.CO.[Pd]>>CCc1cc2c(cc1-c1cnn(C)c1)CCCN2c1nn(C2CCOCC2)c2c1CN(C(=O)NC)CC2",
        "output": "555"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCN(Cc2ccc(OC3CN(C(=O)OC(C)(C)C)C3)cc2F)CC1.ClCCl.O=C(O)C(F)(F)F>>CN1CCN(Cc2ccc(OC3CNC3)cc2F)CC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Fc1ccc2nc(N3CC4CNCC4C3)ncc2c1.O=C(O)c1cccc(F)c1-c1ncccn1>>O=C(c1cccc(F)c1-c1ncccn1)N1CC2CN(c3ncc4cc(F)ccc4n3)CC2C1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CCN(CC)CC.CN(C)C=O.Nc1ncnc2c1c(I)nn2CCCBr>>Nc1ncnc2c1c(I)nn2CCCN1CCOCC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COC(=O)C(OC(C)(C)C)c1c(-c2ccc3c(c2)CCCO3)c(-c2ccccn2)nn1C.O.[K+].[OH-]>>Cn1nc(-c2ccccn2)c(-c2ccc3c(c2)CCCO3)c1C(OC(C)(C)C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNC.CNC(=O)C(C)(C)COc1c(-c2cccc3c2CCC3=O)ccc(OC)c1OC.COc1ccc(-c2cccc3c2CCC3=O)c(OCC(C)(C)C(=O)O)c1OC>>COc1ccc(-c2cccc3c2CCC3=O)c(OCC(C)(C)C(=O)N(C)C)c1OC",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.CCO.CCOC(=O)CBr.O=C([O-])[O-].O=Cc1ccc(O)c(O)c1.[K+].[K+]>>CCOC(=O)COc1ccc(C=O)cc1O",
        "output": "123"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CO.Cc1ccc([N+](=O)[O-])cc1C(=O)N[C@H](C)c1cccc2ccccc12.[Pd]>>Cc1ccc(N)cc1C(=O)N[C@H](C)c1cccc2ccccc12",
        "output": "489"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.O=S(Cl)Cl.OCCSc1ccc(O)cc1.c1ccncc1>>Oc1ccc(SCCCl)cc1",
        "output": "96"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)O.CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.CCN1C(=O)CCCc2c1ccc(N)c2OC.CN([C@@H]1CCCC[C@H]1Nc1nc(Cl)ncc1Cl)S(C)(=O)=O.O=C([O-])[O-]>>CCN1C(=O)CCCc2c1ccc(Nc1ncc(Cl)c(N[C@@H]3CCCC[C@H]3N(C)S(C)(=O)=O)n1)c2OC",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.O=C(c1ccc([N+](=O)[O-])cc1)N1CCCc2ccccc21.[H][H]>>Nc1ccc(C(=O)N2CCCc3ccccc32)cc1",
        "output": "28"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.Cl.FC(F)(F)c1cc(CO[C@H]2CCNC[C@H]2c2ccccc2)cc(C(F)(F)F)c1.O>>CC(=O)N1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1",
        "output": "125"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CSCCN1.CC#N.CCN(C(C)C)C(C)C.O=[N+]([O-])c1ccc(F)c(F)c1>>O=[N+]([O-])c1ccc(N2CCSCC2)c(F)c1",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCCCCC.CN1C(=O)CCc2cc(Br)c(F)cc21.[K+]>>CN1C(=O)CCc2cc(B3OC(C)(C)C(C)(C)O3)c(F)cc21",
        "output": "942"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CC(C)(C)c1ccc(CBr)cc1.COC(=O)c1ccc(CCC(/C=C/c2ccccc2O)Cc2cc(F)c(O[Si](C(C)C)(C(C)C)C(C)C)c(F)c2)cc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(CCC(/C=C/c2ccccc2OCc2ccc(C(C)(C)C)cc2)Cc2cc(F)c(O[Si](C(C)C)(C(C)C)C(C)C)c(F)c2)cc1",
        "output": "127"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.CSc1ncc2ccc(=O)n(Cc3ccccc3Br)c2n1.O.O=S([O-])OO.[K+]>>CS(=O)(=O)c1ncc2ccc(=O)n(Cc3ccccc3Br)c2n1",
        "output": "840"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(Cc1c(C(C)(C)C)[nH]c2cc([N+](=O)[O-])ccc12)OC.[OH-].[OH-].[Pd+2]>>COC(Cc1c(C(C)(C)C)[nH]c2cc(N)ccc12)OC",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.COc1c(CC#N)cccc1Sc1ccccc1Cl.O.[K+].[OH-]>>COc1c(CC(=O)O)cccc1Sc1ccccc1Cl",
        "output": "259"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.O=C(O)c1c(F)cccc1Br.ONCCc1ccc2ccccc2n1>>O=C(c1c(F)cccc1Br)N(O)CCc1ccc2ccccc2n1",
        "output": "828"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCN.COC(=O)c1c[nH]c2ncc(Br)cc12>>CCCCCNC(=O)c1c[nH]c2ncc(Br)cc12",
        "output": "862"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CN(C)C=O.Cc1cc(F)ccc1Br>>Cc1cc(F)ccc1C=O",
        "output": "638"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COCC(=O)Cl.COc1nc2cc(C)c(Cl)c(N)c2nc1OC.ClCCl.c1ccncc1>>COCC(=O)Nc1c(Cl)c(C)cc2nc(OC)c(OC)nc12",
        "output": "422"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCC(N)C(=O)Nc1cn(C(C)(C)CN2CCOCC2)cn1.O=C(O)Cc1cc(F)cc(F)c1>>CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(C(C)(C)CN2CCOCC2)cn1",
        "output": "133"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.NC(=O)c1c(-c2ccc(Oc3ncc(Cl)cc3F)cc2)nn([C@@H]2CCCNC2)c1N.O.O=C(O)/C=C/CO>>NC(=O)c1c(-c2ccc(Oc3ncc(Cl)cc3F)cc2)nn([C@@H]2CCCN(C(=O)/C=C/CO)C2)c1N",
        "output": "870"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCc1nc2c(N)nc3cccnc3c2n1CCCCN.Cc1cn(CC(=O)O)c(=O)nc1O>>CCCCc1nc2c(N)nc3cccnc3c2n1CCCCNC(=O)Cn1cc(C)c(O)nc1=O",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "N[C@@H]1CC[C@@H](CCN2CCC(Oc3c(F)cc(F)cc3F)CC2)CC1.O=C(O)C1CCC1>>O=C(N[C@@H]1CC[C@@H](CCN2CCC(Oc3c(F)cc(F)cc3F)CC2)CC1)C1CCC1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)CN([C@@H](CCCCN)C(=O)O)S(=O)(=O)c1ccc([N+](=O)[O-])cc1.COc1ccc(C=CC(=O)O)c(OC)c1>>COc1ccc(C=CC(=O)NCCCC[C@@H](C(=O)O)N(CC(C)C)S(=O)(=O)c2ccc([N+](=O)[O-])cc2)c(OC)c1",
        "output": "549"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCBr.CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.O=C([O-])[O-].O=S(=O)(c1ccccc1)n1cc(-c2cn[nH]c2)c2ccc(F)cc21.[Cs+].[Cs+].[I-]>>CC(C)(C)OC(=O)NCCn1cc(-c2cn(S(=O)(=O)c3ccccc3)c3cc(F)ccc23)cn1",
        "output": "577"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CCOC(=O)CCc1cc(O)ccc1C.CCOC(C)=O.COc1ccc(F)c(-c2ccc(CCl)nc2CC(C)(C)C)c1.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)CCc1cc(OCc2ccc(-c3cc(OC)ccc3F)c(CC(C)(C)C)n2)ccc1C",
        "output": "616"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#C[C@]1(O)CCN(C)C1=O.NC(=O)c1nc2c(s1)C1CC(C1)c1ccc(Br)cc1-2>>CN1CC[C@@](O)(C#Cc2ccc3c(c2)-c2nc(C(N)=O)sc2C2CC3C2)C1=O",
        "output": "659"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc(-n2c(C(F)(F)F)nc3ccc(F)c(F)c32)c1C.[BH4-].[Li+]>>Cc1c(CO)cccc1-n1c(C(F)(F)F)nc2ccc(F)c(F)c21",
        "output": "444"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)C1(C=NOCc2ccccc2)C[C@H](C)C[C@H](C)C1.Cl.O.O.[Li+].[OH-]>>C[C@@H]1C[C@H](C)CC(C=NOCc2ccccc2)(C(=O)O)C1",
        "output": "361"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(N)c1.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1cccc(CBr)c1.[K+].[K+]>>CC(C)(C)OC(=O)Nc1cccc(NCc2cccc([N+](=O)[O-])c2)c1",
        "output": "272"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=O)NC1CCCc2c(Br)cncc21.OB(O)c1ccc(C(F)(F)F)c(F)c1>>CCC(=O)NC1CCCc2c(-c3ccc(C(F)(F)F)c(F)c3)cncc21",
        "output": "833"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrB(Br)Br.COc1ccccc1OCC(F)(F)F.ClCCl>>Oc1ccccc1OCC(F)(F)F",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCCCCCCCC(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COc1ccc(C(OC(c2ccccc2)C2CC(O)CN2C(=O)CCCCCN)c2ccc(OC)cc2)cc1.F[P-](F)(F)(F)(F)F>>CCCCCCCCCCCCCC(=O)NCCCCCC(=O)N1CC(O)CC1C(OC(c1ccc(OC)cc1)c1ccc(OC)cc1)c1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN(C)c1cccc2c(S(=O)(=O)Cl)cccc12.ClCCl.O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCNCC1>>CN(C)c1cccc2c(S(=O)(=O)N3CCC(NC(=O)Nc4ccc(OC(F)(F)F)cc4)CC3)cccc12",
        "output": "99"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.Cc1ccc(-n2nc(C)cc2N)cc1.Cc1ccc(C(=O)O)cc1I.ClCCl.O.O=S(Cl)Cl>>Cc1ccc(-n2nc(C)cc2NC(=O)c2ccc(C)c(I)c2)cc1",
        "output": "917"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CCOC(C)=O.CO.COc1cc(C(=O)Cl)cc(OC)c1OC.COc1ccc(C2(CCO)CCNC2)cc1OC.ClCCl.ClCCl.O.O=C([O-])O.O=C([O-])[O-].[Na+].[Na+].[Na+]>>COc1ccc(C2(CCO)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC",
        "output": "201"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.O=C([O-])N=NC(=O)[O-].O=C(c1nsc2cc(O)ccc12)N1CCN2CCC1CC2.OCC1CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(c1nsc2cc(OCC3CC3)ccc12)N1CCN2CCC1CC2",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)C1(c2ccc(Cl)nc2)CC1.O=C([O-])O.[Cl-].[NH4+].[Na+]>>NC(=O)C1(c2ccc(Cl)nc2)CC1",
        "output": "313"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](N)C1=O.CCN(C(C)C)C(C)C.CCNC(=O)Nc1ccc(C(F)(F)F)cc1C(=O)O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O>>CCC[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NCC)C1=O",
        "output": "718"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C)(Cc1ccc(OCc2ccccc2)cc1)Oc1ccc(F)c(F)c1.CCOC(C)=O.[Pd]>>CCOC(=O)C(C)(Cc1ccc(O)cc1)Oc1ccc(F)c(F)c1",
        "output": "23"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>COC(=O)[C@H](Cc1ccc(OS(=O)(=O)C(F)(F)F)cc1)NC(=O)OC(C)(C)C",
        "output": "731"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2CC.CCOCCBr.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOCCOc1cc2c(cc1OC)-c1cc(=O)c(C(=O)OCC)cn1C(CC)C2",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COC(=O)CCN(C)C.NN>>CN(C)CCC(=O)NN",
        "output": "130"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.COC(=O)c1cc2ccc[n+]([O-])c2s1.O=[N+]([O-])O>>COC(=O)c1cc2cc([N+](=O)[O-])c[n+]([O-])c2s1",
        "output": "328"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.COC(=O)c1c[nH]c(Br)c1C.Cc1ccccc1.O.O=C([O-])[O-].OB(O)c1ccc(F)cc1C(F)(F)F.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1c[nH]c(-c2ccc(F)cc2C(F)(F)F)c1C",
        "output": "869"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1ccc(C=O)cc1O.FC(F)CBr.O=C([O-])[O-].[K+].[K+]>>COc1ccc(C=O)cc1OCC(F)F",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CN(C)C=O.[Li]CCCC.c1ccc(Sc2cccs2)cc1>>O=Cc1ccc(Sc2ccccc2)s1",
        "output": "617"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1ccccc1.CC(C)(C)OC(=O)n1nc(-c2ccccc2)c2ccc(N)cc21>>CC(C)(C)OC(=O)n1nc(-c2ccccc2)c2ccc(Nc3ccccc3)cc21",
        "output": "405"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(C)cc(N=C=O)c1.NC(=O)c1[nH]c2cnccc2c1-c1ccc(N)cc1>>Cc1cc(C)cc(NC(=O)Nc2ccc(-c3c(C(N)=O)[nH]c4cnccc34)cc2)c1",
        "output": "473"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(N)CO.Cc1cc(F)ccc1-c1nc(S(C)(=O)=O)nc2c1ccc(=O)n2-c1ccccc1F>>Cc1cc(F)ccc1-c1nc(NC(C)(C)CO)nc2c1ccc(=O)n2-c1ccccc1F",
        "output": "629"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCc1cc(C(=O)O)no1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.ClC(Cl)Cl.NCC1CCOC1.On1nnc2ccccc21>>CCCc1cc(C(=O)NCC2CCOC2)no1",
        "output": "696"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1nc(N)sc1C(=O)NCc1ccccc1.O=C(Cl)c1ccccc1F>>Cc1nc(NC(=O)c2ccccc2F)sc1C(=O)NCc1ccccc1",
        "output": "673"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(O)cc1F.[Cl-].[K+].[K+].[Na+]>>O=[N+]([O-])c1ccc(OCc2ccccc2)cc1F",
        "output": "127"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1ccc(CNc2nc(N)nc(NC3Cc4ccccc4C3)n2)cc1.Cl.O.O.[Li]O>>Nc1nc(NCc2ccc(C(=O)O)cc2)nc(NC2Cc3ccccc3C2)n1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N(CCOc1cc(Cl)cc(C(=O)N(CCCC(=O)O)C2CCCC2)c1)c1ccncc1.O=C(O)C(F)(F)F>>O=C(O)CCCN(C(=O)c1cc(Cl)cc(OCCNc2ccncc2)c1)C1CCCC1",
        "output": "830"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.COc1ccc(CC(C)N(Cc2ccccc2)CC(O)c2ccc(OCc3ccccc3)c([N+](=O)[O-])c2)cc1.O=C[O-].[NH4+].[Pd]>>COc1ccc(CC(C)N(Cc2ccccc2)CC(O)c2ccc(OCc3ccccc3)c(N)c2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "FC(F)(F)c1nnc2ccc(N3CCNCC3)nn12.N#Cc1ccc(S(=O)(=O)Cl)cc1>>N#Cc1ccc(S(=O)(=O)N2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1",
        "output": "99"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCNCC.CS(=O)(=O)OCCC1(c2ccccc2)C=CCC=C1.Cc1ccccc1>>CCN(CC)CCC1(c2ccccc2)C=CCC=C1",
        "output": "496"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.Nc1ccccc1S(=O)(=O)Nc1cccc2cccnc12.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Nc1ccccc1S(=O)(=O)Nc1cccc2cccnc12)C(F)(F)F",
        "output": "106"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.FC(F)(F)c1ccnc(Cl)c1.O.O=c1[nH]cnc2c1CCNC2>>O=c1[nH]cnc2c1CCN(c1cc(C(F)(F)F)ccn1)C2",
        "output": "220"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccc(I)cc1.O=[N+]([O-])c1cn2c(n1)OCC(CO)C2.[H-].[Na+]>>O=[N+]([O-])c1cn2c(n1)OCC(COCc1ccc(I)cc1)C2",
        "output": "464"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C[C@]12CC[C@H]3[C@@H](CC[C@H]4C(=[N+]=[N-])C(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2CO.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>C[C@]12CC[C@H]3[C@@H](CC[C@H]4C(=[N+]=[N-])C(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C=O",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.O.O=C(Nc1nc2ccc(O)cn2n1)C1CC1.O=C([O-])[O-].O=[N+]([O-])c1cc(F)cc(F)c1.[K+].[K+]>>O=C(Nc1nc2ccc(Oc3cc(F)cc([N+](=O)[O-])c3)cn2n1)C1CC1",
        "output": "845"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.OC1CCN(c2ncc(-c3ccc(Cl)cc3Cl)cn2)CC1>>CC(=O)OC1CCN(c2ncc(-c3ccc(Cl)cc3Cl)cn2)CC1",
        "output": "254"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)[C@@H](N)Cc1ccccn1.C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O.Cl.ClCCl>>COC(=O)[C@H](Cc1ccccn1)NC(=O)[C@H](C)NC(=O)Cc1cc(F)cc(F)c1",
        "output": "129"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C1(N)Cc2ccccc2C1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1cccc(C(=O)O)c1C.F[P-](F)(F)(F)(F)F>>CCOC(=O)C1(NC(=O)c2cccc(C)c2C)Cc2ccccc2C1",
        "output": "709"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Clc1ccccc1Cl.O=C(Cl)C(=O)Cl.O=C(O)CCc1nn[nH]n1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(CCc1nn[nH]n1)c1ccc(Cl)c(Cl)c1",
        "output": "435"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(N2C(=O)CC(=O)N(Cc3ccc([N+](=O)[O-])cc3)c3ccccc32)cc1.CO.[Pd]>>CC(C)(C)OC(=O)NCc1ccc(N2C(=O)CC(=O)N(Cc3ccc(N)cc3)c3ccccc32)cc1",
        "output": "507"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.ClCCl.Nc1cnc2c(c1)COC(COCc1ccccc1)C2.O>>Nc1cnc2c(c1)COC(CO)C2",
        "output": "178"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.Clc1ccc(C(c2ccccc2)N2CCNCC2)cc1.O=S(=O)(CCCCCCCCCCCBr)NC1CC1>>O=S(=O)(CCCCCCCCCCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1)NC1CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NC1CCNCC1.CCN(CC)CC.CCOC(=O)CCC(=O)Cl.ClCCl>>CCOC(=O)CCC(=O)N1CCC(NC(=O)OC(C)(C)C)CC1",
        "output": "125"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1noc(-c2ccc(Br)cc2)c1CN.O=C(Cl)OCc1ccccc1>>Cc1noc(-c2ccc(Br)cc2)c1CNC(=O)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@H](CCCNC(=N)N)C(=O)O.Cl.NCc1ccccc1>>CC(C)(C)OC(=O)N[C@H](CCCNC(=N)N)C(=O)NCc1ccccc1",
        "output": "599"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)C=O.CC(C)(C)[Si](C)(C)OCCN.CC(C)(C)[Si](C)(C)OCCNC1CCCC1>>CC(C)(C)CNCCO[Si](C)(C)C(C)(C)C",
        "output": "426"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCc1c(OCCCCCOc2ccc3c(c2CCC)OC(C(=O)OCC)CC3=O)ccc(C(C)=O)c1O.CCO.[Na+].[OH-]>>CCCc1c(OCCCCCOc2ccc3c(c2CCC)OC(C(=O)O)CC3=O)ccc(C(C)=O)c1O",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCO.COc1ccc(NC(=O)CC2CO2)cc1.Cc1cccc(C)c1NC(=O)CN1CCNCC1>>COc1ccc(NC(=O)CC(O)CN2CCN(CC(=O)Nc3c(C)cccc3C)CC2)cc1",
        "output": "76"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)C1C(=O)NCCN1C[C@H]1CN(S(=O)(=O)c2ccc([N+](=O)[O-])s2)CCN1.CCN(C(C)C)C(C)C.OC(c1cnc(Cl)nc1)(C(F)(F)F)C(F)(F)F>>CC(C)C1C(=O)NCCN1C[C@H]1CN(S(=O)(=O)c2ccc([N+](=O)[O-])s2)CCN1c1ncc(C(O)(C(F)(F)F)C(F)(F)F)cn1",
        "output": "36"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CSc1nc2[nH]c(-c3ccnc(/C=C/c4ccccc4)c3)cc2c(=O)[nH]1.NCC(O)CO>>O=c1[nH]c(NCC(O)CO)nc2[nH]c(-c3ccnc(/C=C/c4ccccc4)c3)cc12",
        "output": "101"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrBr.CCC(=O)CC(=O)OC>>COC(=O)CC(=O)C(C)Br",
        "output": "82"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3cccc(S(=O)(=O)NC(C)(C)C)c3)c1)=N2.O=C(O)C(F)(F)F>>CCOc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3cccc(S(N)(=O)=O)c3)c1)=N2",
        "output": "680"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.Cc1ccccc1.Cn1nc(N2CCNCC2)c(=O)n(C)c1=O.Fc1ccc(CBr)c(C(F)(F)F)c1.O>>Cn1nc(N2CCN(Cc3ccc(F)cc3C(F)(F)F)CC2)c(=O)n(C)c1=O",
        "output": "248"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCO.CN1CC(CCCCCl)OC1=O.Cl.O=C([O-])[O-].[I-].[K+].[K+].[K+].c1ccc(N2CCNCC2)cc1>>CN1CC(CCCCN2CCN(c3ccccc3)CC2)OC1=O",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(Cl)c(Oc2cc(Br)c(F)cc2[N+](=O)[O-])c1F.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>O=[N+]([O-])c1cc(F)c(Br)cc1Oc1c(Cl)ccc(CBr)c1F",
        "output": "29"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(Oc1ccc(Cl)nc1Cl)C(=O)O.CN(C)C=O.ClC(Cl)Cl.O=S(Cl)Cl>>CC(Oc1ccc(Cl)nc1Cl)C(=O)Cl",
        "output": "53"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cc2ccc(NS(C)(=O)=O)cc2n1C(=O)OC(C)(C)C.CO.O.[Li+].[OH-]>>CC(C)(C)OC(=O)n1c(C(=O)O)cc2ccc(NS(C)(=O)=O)cc21",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)Nc1cc(N2CCOCC2)c(C(F)(F)F)cc1NC(=O)CC(=O)c1cccc(-n2cnnc2)c1.ClCCl.O=C(O)C(F)(F)F>>O=C1CC(c2cccc(-n3cnnc3)c2)=Nc2cc(N3CCOCC3)c(C(F)(F)F)cc2N1",
        "output": "930"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(O)Cc1ccc(OCc2ccccc2)cc1OCc1ccccc1.O=S(Cl)Cl.c1ccccc1>>O=C(Cl)Cc1ccc(OCc2ccccc2)cc1OCc1ccccc1",
        "output": "53"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C1(CC#N)CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)C1(CC#N)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)n1nc(N)nc1-c1cn2c(n1)-c1cc(Br)ccc1OCC2.O.O=C([O-])[O-].OB(O)c1ccccc1.[Cs+].[Cs+]>>CC(C)n1nc(N)nc1-c1cn2c(n1)-c1cc(-c3ccccc3)ccc1OCC2",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCNCC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O=C(O)CC1c2cc([N+](=O)[O-])ccc2CCN1C(=O)OCc1ccccc1.On1nnc2ccccc21.[Cl-].[Na+]>>CCN(CC)C(=O)CC1c2cc([N+](=O)[O-])ccc2CCN1C(=O)OCc1ccccc1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN1CCCC1=O.Cc1c(Cl)nnc(Cl)c1C.FC(F)(F)c1ccc(N2CCNCC2)nc1>>Cc1c(Cl)nnc(N2CCN(c3ccc(C(F)(F)F)cn3)CC2)c1C",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.ClCCl.O=P(Cl)(Cl)Cl.Oc1ccnc2cc(Cl)c(I)cc12>>Clc1cc2nccc(Cl)c2cc1I",
        "output": "177"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC(=O)c1cc2c(=O)c(C(=O)OCC)c[nH]c2cc1C.CCO.[Na+].[OH-]>>CCCC(=O)c1cc2c(=O)c(C(=O)O)c[nH]c2cc1C",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.Cl.Clc1cc(Cl)ncn1.FC(F)(F)C1CCNCC1.O>>FC(F)(F)C1CCN(c2cc(Cl)ncn2)CC1",
        "output": "162"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O[Si](C)(C)C(C)(C)C)C(OC)C3)C(C)C(O[Si](C)(C)C(C)(C)C)CC1=O)C(C)CC2OC.CCOC(C)=O.F>>CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(OC)C3)C(C)C(O[Si](C)(C)C(C)(C)C)CC1=O)C(C)CC2OC",
        "output": "708"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCN(C(C)C)C(C)C.ClCCCCn1cnc2ccccc21.[I-].[K+].c1ccc2nc(N3CCNCC3)cnc2c1>>c1ccc2nc(N3CCN(CCCCn4cnc5ccccc54)CC3)cnc2c1",
        "output": "138"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(=O)(=O)Cl.c1cc2c(cc1OCCCN1CCCCC1)CCNCC2>>CS(=O)(=O)N1CCc2ccc(OCCCN3CCCCC3)cc2CC1",
        "output": "584"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CCNC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)C=O.Cc1cn2nc(-c3cc(=O)n4cc(Br)ccc4n3)cc2c(C)n1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O.[Cu]I>>Cc1cn2nc(-c3cc(=O)n4cc(C#CCNC(=O)OC(C)(C)C)ccc4n3)cc2c(C)n1",
        "output": "719"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C=CCCCCO.CN(C)c1ccncc1.ClCCl.O=C(O)CBr>>C=CCCCCOC(=O)CBr",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1cccc(N=C=O)c1.CCN(CC)CC.Cl.Cl.ClCCl.N[C@@H]1COC[C@H]1NC1CCC(Cc2ccc(F)cc2)CC1>>CC(=O)c1cccc(NC(=O)N[C@@H]2COC[C@H]2NC2CCC(Cc3ccc(F)cc3)CC2)c1",
        "output": "35"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CS(=O)(=NC(=O)Nc1cccnc1)c1ccc(N)cc1.C[C@H](CO)Nc1nc(Cl)ncc1-c1cccs1>>C[C@H](CO)Nc1nc(Nc2ccc(S(C)(=O)=NC(=O)Nc3cccnc3)cc2)ncc1-c1cccs1",
        "output": "808"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.ClCCl.O.O=C(Nc1nccn1Cc1cc(Cl)cc(Cl)c1)c1ccccc1.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>Clc1cc(Cl)cc(Cn2ccnc2NCc2ccccc2)c1",
        "output": "215"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1ccc2sc3ccccc3c2c1.CC(C)(C)[O-].COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1ccccc1C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(-n2c3ccccc3c3cc(-c4ccc5[nH]c6ccccc6c5c4)ccc32)cc1>>c1ccc(-n2c3ccccc3c3cc(-c4ccc5c(c4)c4ccccc4n5-c4ccc5sc6ccccc6c5c4)ccc32)cc1",
        "output": "349"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc(OC)c(-c2cc3nccc(Cl)c3o2)c1.O.[Li+].[OH-]>>COc1ccc(C(=O)O)cc1-c1cc2nccc(Cl)c2o1",
        "output": "222"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)NCCc1cccc(F)c1O.COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCCOS(=O)(=O)c2ccc(C)cc2)cc1>>COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCCOc2c(F)cccc2CCNC(C)=O)cc1",
        "output": "438"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)CCCCN.Cl.Cl.O.O=C(O)C=C1c2ccccc2-c2ccccc21.Oc1cccc2[nH]nnc12.[Cl-].[Na+]>>COC(=O)CCCCNC(=O)C=C1c2ccccc2-c2ccccc21",
        "output": "549"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)Cc1ccnc2c1cc(-c1cn(C)c3cc(OC)c(OC)cc13)n2S(=O)(=O)c1ccc(C)cc1.[K+].[OH-]>>CCN(CC)Cc1ccnc2[nH]c(-c3cn(C)c4cc(OC)c(OC)cc34)cc12",
        "output": "949"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.C=Cc1ccc(B(O)O)cc1.CC(C)(C)P.CC(C)(C)P(C(C)(C)C)C(C)(C)C.Clc1ccccc1-c1ccncc1.F[K].O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Pd]>>C=Cc1ccc(-c2ccccc2-c2ccncc2)cc1",
        "output": "892"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCO.Cc1ccc(S(=O)(=O)O)cc1.O.O=C(CBr)c1ccc(Cl)cc1Cl.OCC(O)c1ccccc1.c1ccccc1>>Clc1ccc(C2(CBr)OCC(c3ccccc3)O2)c(Cl)c1",
        "output": "93"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CI.CN(C)C=O.COc1ccc(-c2nc(-c3cccnc3)c(C)[nH]2)c(OC)c1.O.[H-].[Na+]>>COc1ccc(-c2nc(-c3cccnc3)c(C)n2C)c(OC)c1",
        "output": "404"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.Nc1cc(Cl)c(Cl)cc1[N+](=O)[O-].O.O.O=C(O)C(F)(F)F.O=C([O-])[O-].OC[C@H]1CCCN1.[K+].[K+]>>Nc1cc(N2CCC[C@@H]2CO)c(Cl)cc1[N+](=O)[O-]",
        "output": "105"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CN1CCNCC1.Cc1[nH]c(C=O)c(C)c1C(=O)O.F[P-](F)(F)(F)(F)F.O.O.[Cl-].[Na+].[Na+].[OH-]>>Cc1[nH]c(C=O)c(C)c1C(=O)N1CCN(C)CC1",
        "output": "256"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(Oc4ccc(O[Si](C)(C)C(C)(C)C)cc4)C(O)C3)C(C)C(O)CC1=O)C(C)CC2OC.CO.Cc1ccc(S(=O)(=O)O)cc1.ClCCl>>CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(Oc4ccc(O)cc4)C(O)C3)C(C)C(O)CC1=O)C(C)CC2OC",
        "output": "754"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc(Br)ccc1C(=O)O.NC1CCOCC1>>Cc1cc(Br)ccc1C(=O)NC1CCOCC1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.N#Cc1ccc(F)cc1.N[C@H]1CC[C@H](O)CC1.[H-].[Na+]>>N#Cc1ccc(O[C@@H]2CC[C@@H](N)CC2)cc1",
        "output": "485"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "B.C1CCOC1.Cl.N#CCc1ccc(Br)cc1>>NCCc1ccc(Br)cc1",
        "output": "246"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(C)=O.COc1cc([N+](=O)[O-])c(OC)cc1N1CCC(N2CCCCC2)CC1.[Pt]>>COc1cc(N2CCC(N3CCCCC3)CC2)c(OC)cc1N",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1cnc2c(C(F)(F)F)cccc2c1-c1ccccc1.CO.[Na+].[OH-]>>O=C(O)c1cnc2c(C(F)(F)F)cccc2c1-c1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O=C(O)c1ccc(O)nc1.O=C([O-])O.O=S(=O)(O)O.[Na+]>>CCOC(=O)c1ccc(O)nc1",
        "output": "521"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CCOC(C)=O.CI.Cl.O.O=[N+]([O-])c1ccc2c(-c3ccccc3)c[nH]c2c1.[H-].[Na+]>>Cn1cc(-c2ccccc2)c2ccc([N+](=O)[O-])cc21",
        "output": "191"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cccc(CN(C(=O)C2=C(c3nc(C)c(CCO)s3)CC3CN(C(=O)OC(C)(C)C)CC2N3C(=O)OC(C)(C)C)C2CC2)c1C.Cc1cc(O)cc(C)c1Cl>>COc1cccc(CN(C(=O)C2=C(c3nc(C)c(CCOc4cc(C)c(Cl)c(C)c4)s3)CC3CN(C(=O)OC(C)(C)C)CC2N3C(=O)OC(C)(C)C)C2CC2)c1C",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=C1c2ccccc2CC1CC(=O)N1CSC[C@H]1C(=O)N1CCCC1.[BH4-].[Na+]>>O=C([C@@H]1CSCN1C(=O)CC1Cc2ccccc2C1O)N1CCCC1",
        "output": "24"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1ccc([C@@H](C)OC(=O)Nc2c(C)noc2-c2ccc(Br)cc2)cc1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4NC(=O)O[C@H](C)c4ccc(C)cc4)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1.O=C=Nc1ccccc1>>O=C1CC(=O)N(c2ccc(NC(=O)Nc3ccccc3)cc2)c2ccc3ccccc3c2N1",
        "output": "473"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "B.C1CCOC1.CCCCc1c(C(=O)O)ccc2c(OC)cccc12>>CCCCc1c(CO)ccc2c(OC)cccc12",
        "output": "72"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COc1ccc(-n2nc(C3(O)CCC4(CC3)OCCO4)cc2-c2ccc(Cl)cc2)cc1.Cl.[Na+].[OH-]>>COc1ccc(-n2nc(C3(O)CCC(=O)CC3)cc2-c2ccc(Cl)cc2)cc1",
        "output": "251"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=C1CN(C(=O)OC(C)(C)C)C1.CC#N.CC(=O)[O-].CC(=O)[O-].CC1C(=O)NN=C2COc3ccc(Br)cc3N21.CCN(CC)CC.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.[Pd+2]>>CC1C(=O)NN=C2COc3ccc(C=C4CN(C(=O)OC(C)(C)C)C4)cc3N21",
        "output": "539"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCO.CCOC(=O)CCCn1cc(C(=O)c2ccc(OC(C(=O)OCc3ccccc3)c3ccc(CC(C)C)cc3)cc2)c2ccccc21.[Pd]>>CCOC(=O)CCCn1cc(C(=O)c2ccc(OC(C(=O)O)c3ccc(CC(C)C)cc3)cc2)c2ccccc21",
        "output": "186"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)C[AlH]CC(C)C.COC(=O)C1CN(C(=O)OC(C)(C)C)c2cc([N+](=O)[O-])c3ccccc3c21.Cc1ccccc1>>CC(C)(C)OC(=O)N1CC(CO)c2c1cc([N+](=O)[O-])c1ccccc21",
        "output": "343"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)Cl.Nc1cccc(Br)n1.c1ccncc1>>CCOC(=O)Nc1cccc(Br)n1",
        "output": "502"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.Oc1ccc(C(O)C(Cl)(Cl)Cl)cc1.c1ccncc1>>CC(=O)Oc1ccc(C(O)C(Cl)(Cl)Cl)cc1",
        "output": "46"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1ccnc(C)c1.CO.Cl.NO.[Na+].[OH-]>>CC(=NO)c1ccnc(C)c1",
        "output": "212"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)c1cc(N)n(-c2ccccc2)n1.[Na+].[OH-]>>Nc1cc(C(=O)O)nn1-c1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc2c(cc1OC)C(=O)CC2.O.O=Cc1ccncc1.[Na+].[OH-]>>COc1cc2c(cc1OC)C(=O)C(=Cc1ccncc1)C2",
        "output": "85"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(Br)cc1.O=C(Cl)CCCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(Br)cc1C(=O)CCCCl",
        "output": "31"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOc1ccccc1OCCN(C(=O)OC(C)(C)C)C(C)Cc1cc2c(c(C(N)=O)c1)N(C(C)=O)CC2.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CCOc1ccccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(C(C)=O)CC2",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)N1CCNCC1.N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(F)cc3C(F)(F)F)C[C@H]2C(=O)N2CC(F)(F)C2)CC1>>CC(C)(C)N1CCN(c2ccc(S(=O)(=O)[C@@H]3C[C@@H](C(=O)NC4(C#N)CC4)[C@H](C(=O)N4CC(F)(F)C4)C3)c(C(F)(F)F)c2)CC1",
        "output": "26"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1nc(N2CCN(CC(C)C)C2=O)sc1C(=O)O.NCc1cncc(F)c1.NCc1cocn1>>Cc1nc(N2CCN(CC(C)C)C2=O)sc1C(=O)NCc1cocn1",
        "output": "534"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)CC(=O)Cl.CCC(CC)(Cc1cc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Cl)cc1)C(=O)OC.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CCC(CC)(Cc1c(C(=O)CC(C)(C)C)c2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Cl)cc1)C(=O)OC",
        "output": "524"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Nc1ccc(CO)cc1.On1nnc2ccccc21>>CC(C)(C)OC(=O)NCC(=O)Nc1ccc(CO)cc1",
        "output": "365"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OCc1cccc(C(=O)N2CCOCC2)n1.CCO.[K+].[OH-]>>O=C(c1cccc(CO)n1)N1CCOCC1",
        "output": "348"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1c(-c2ccc(C(C)(C)C)cc2)c2ccccc2n1Cc1cc(OCc2ccccc2)cc(OCC2CC2)c1.CO.Cl.[Na+].[OH-]>>CC(C)(C)c1ccc(-c2c(C(=O)O)n(Cc3cc(OCc4ccccc4)cc(OCC4CC4)c3)c3ccccc23)cc1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)OC)c1.CO.Cl.O.O.[Li+].[OH-]>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1c[nH]c2cc([N+](=O)[O-])ccc12.CCO.[Ni]>>CC(C)(C)c1c[nH]c2cc(N)ccc12",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)NS(=O)(=O)c1cccc(-c2cn(-c3cc(C(F)(F)F)cc(-c4ccc(C(F)(F)F)cc4)n3)cn2)c1.ClCCl.O=C(O)C(F)(F)F>>NS(=O)(=O)c1cccc(-c2cn(-c3cc(C(F)(F)F)cc(-c4ccc(C(F)(F)F)cc4)n3)cn2)c1",
        "output": "680"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COC(=O)c1cc(F)cc([N+](=O)[O-])c1.[Cl-].[Fe].[NH4+]>>COC(=O)c1cc(N)cc(F)c1",
        "output": "481"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)[C@H](CN)NC(=O)OCc1ccccc1.CCN(C(C)C)C(C)C.CCOC(=O)CCN1CCn2nc(C(=O)O)cc2C1=O.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F>>CCOC(=O)CCN1CCn2nc(C(=O)NC[C@H](NC(=O)OCc3ccccc3)C(=O)OC(C)(C)C)cc2C1=O",
        "output": "816"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@H](N=[N+]=[N-])CC1.CCOC(C)=O.[Pd]>>CC(C)(C)OC(=O)N[C@@H]1CC[C@H](N)CC1",
        "output": "89"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN1CCC(=O)CC1.CN1CCCC1=O.ClCCl.O=C([O-])O.O=C1NC(=O)c2ccc(I)cc2/C1=C/Nc1ccc(N2CCNCC2)cc1.[Na+].[Na+]>>CN1CCC(N2CCN(c3ccc(N/C=C4\\C(=O)NC(=O)c5ccc(I)cc54)cc3)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC1CCC(=O)N1.Nc1cccc(I)c1.O=C([O-])[O-].[Cs+].[Cs+].[Cu]I>>CC1CCC(=O)N1c1cccc(N)c1",
        "output": "921"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COc1ccc(C(O)(C(C)c2ccc(-c3ccc(CC#N)cc3)cc2Cl)C(F)(F)F)cn1.Cl.O>>CC(c1ccc(-c2ccc(CC#N)cc2)cc1Cl)C(O)(c1ccc(=O)[nH]c1)C(F)(F)F",
        "output": "758"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc2ncc3c(c2c1)CCCC3.c1ccncc1>>O=S(=O)(Oc1ccc2ncc3c(c2c1)CCCC3)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1sc(Cc2ccccc2)c(-c2ccc(-c3ccc(O)cc3)cc2)c1C.O=C(O)c1ccc(S(=O)(=O)Cl)cc1O>>Cc1sc(Cc2ccccc2)c(-c2ccc(-c3ccc(OS(=O)(=O)c4ccc(C(=O)O)c(O)c4)cc3)cc2)c1C",
        "output": "380"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1cn(COCC[Si](C)(C)C)c2nccc(-n3cnc(-c4ccccc4)c3)c12.[F-]>>Cc1c[nH]c2nccc(-n3cnc(-c4ccccc4)c3)c12",
        "output": "897"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CNCC(O)CO.Cc1c(-c2cccc(C(=O)O)c2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12>>Cc1c(-c2cccc(C(=O)N(C)CC(O)CO)c2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.C[Si](C)(C)C#Cc1ccc2c(nnn2CC2CC2)c1Cl.O=C([O-])[O-].[K+].[K+]>>C#Cc1ccc2c(nnn2CC2CC2)c1Cl",
        "output": "337"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)OC(C)C.CO.Cl.O=C(O)CCC[C@@]12CCCc3cccc(c31)NC2=O>>COC(=O)CCC[C@@]12CCCc3cccc(c31)NC2=O",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "B.C1CCOC1.C1CCOC1.NC(=O)c1ccc(-c2cnco2)cc1>>NCc1ccc(-c2cnco2)cc1",
        "output": "215"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCNc1ncc(Br)cc1NS(=O)(=O)c1ccc(OC)cc1.[K+]>>CCNc1ncc(B2OC(C)(C)C(C)(C)O2)cc1NS(=O)(=O)c1ccc(OC)cc1",
        "output": "943"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOCC.O=C(O)Cc1cccc(F)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCc1cccc(F)c1",
        "output": "231"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[Pd]c1ccccc1-c1ccccc1P(C(C)(C)C)C(C)(C)C.CCO.CN1Cc2ccc(Cl)nc2O[C@H](c2ccccc2)C1.COCCOC.Cn1cc(-c2ccc(N)nc2)cn1.O=C([O-])[O-].[Cs+].[Cs+]>>CN1Cc2ccc(Nc3ccc(-c4cnn(C)c4)cn3)nc2O[C@H](c2ccccc2)C1",
        "output": "606"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COB(OC)OC.Fc1ccc(-c2cc3c(cc2Br)OCO3)cc1.[Li]CCCC.[Na+].[OH-]>>OB(O)c1cc2c(cc1-c1ccc(F)cc1)OCO2",
        "output": "789"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.ClCCl.OCC1CCCCC1>>CS(=O)(=O)OCC1CCCCC1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)CC(C)C.O.O=C([O-])[O-].O=c1[nH]c2ccccc2n1CCCCl.OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCNCC1.[I-].[K+].[Na+].[Na+]>>O=c1[nH]c2ccccc2n1CCCN1CCC(O)(c2ccc(Cl)c(C(F)(F)F)c2)CC1",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)NS(=O)(=O)c1cccc(-c2cccc(-c3nc(-c4ccc(Cl)s4)cc(C(F)(F)F)n3)c2)c1.ClCCl.O=C(O)C(F)(F)F>>NS(=O)(=O)c1cccc(-c2cccc(-c3nc(-c4ccc(Cl)s4)cc(C(F)(F)F)n3)c2)c1",
        "output": "680"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Cc1cccc(C(F)(F)F)n1.CC[SiH](CC)CC.ClCCl.O=C(O)C(F)(F)F>>O=C(O)Cc1cccc(C(F)(F)F)n1",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCC(=O)N(C)c1ccc([N+](=O)[O-])cc1.CCO.[Pd]>>CCCC(=O)N(C)c1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNCC1.CCOCC.CN(C)C=O.O=C(Nc1cc(Oc2ccc3c(ccn3C(=O)NC3CC3)c2)ccn1)N1CCC(N2CCCC2)CC1.O=C(Nc1cc(Oc2ccc3c(ccn3C(=O)NC3CC3)c2)ccn1)Oc1ccccc1>>O=C(Nc1cc(Oc2ccc3c(ccn3C(=O)NC3CC3)c2)ccn1)N1CCCCC1",
        "output": "525"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)Nc1ccccc1C(=O)O.CCN(C(C)C)C(C)C.CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CN.CN(C)C=O.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1ccccc1NC(=O)OC(C)(C)C",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N1c2ccc(Br)cc2[C@H](N)C[C@@H]1C.CCN(C(C)C)C(C)C.CN1CCCC1=O.O.O=[N+]([O-])c1ccc(Cl)nc1>>CC(=O)N1c2ccc(Br)cc2[C@H](Nc2ccc([N+](=O)[O-])cn2)C[C@@H]1C",
        "output": "612"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(C3CCNCC3)cc1OCC2.CN(C)C=O.COCCBr.ClCCl.O=C(O)C(F)(F)F.O=C([O-])[O-].[K+].[K+]>>COCCN1CCC(c2ccc3c(c2)OCCn2cc(-c4ncnn4C(C)C)nc2-3)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.ClCCl.Nc1cncc(-c2nnc(NCc3ccccc3)c3c(-c4ccccc4)cccc23)c1.c1ccncc1>>CC(=O)Nc1cncc(-c2nnc(NCc3ccccc3)c3c(-c4ccccc4)cccc23)c1",
        "output": "422"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)O.CN.CO.COc1cc(-c2cc(-c3cc4ccccc4n3C(=O)OC(C)(C)C)c(OC)nn2)cc(C=O)c1OCOCC[Si](C)(C)C.[BH3-]C#N.[Na+]>>CNCc1cc(-c2cc(-c3cc4ccccc4n3C(=O)OC(C)(C)C)c(OC)nn2)cc(OC)c1OCOCC[Si](C)(C)C",
        "output": "468"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COc1ccncc1C=O.[BH4-].[Na+]>>COc1ccncc1CO",
        "output": "476"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br.Cc1ccc(N)cc1C#N.O.O=N[O-].[Na+]>>Cc1ccc(Br)cc1C#N",
        "output": "373"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.Cl.O=C([O-])O.O=[N+]([O-])c1ccc2c(c1)CNCC2.[Na+]>>CC(C)(C)OC(=O)N1CCc2ccc([N+](=O)[O-])cc2C1",
        "output": "867"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCCCCCCCCCOc1ccc(C(=O)OC)cc1C(C)(C)C.CCO.CO.Cl.ClC(Cl)Cl.O.[K+].[OH-]>>CCCCCCCCCCCCCCOc1ccc(C(=O)O)cc1C(C)(C)C",
        "output": "222"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)[C@H](NS(=O)(=O)N1CCC(Oc2ccc(Cl)cn2)CC1)C(C)C.Cl.O.O.[Li+].[OH-]>>CC(C)[C@@H](NS(=O)(=O)N1CCC(Oc2ccc(Cl)cn2)CC1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCN1.CCCOc1ccc(C=O)c(OCCCCC(=O)O)c1C>>CCCOc1ccc(C=O)c(OCCCCC(=O)N2CCOCC2)c1C",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CN(C)c1ccncc1.CN1CCOCC1.ClCCCl.NC(=O)[C@@H](NC(=O)[C@@H]1CCCC[C@H]1N1CCNCC1)c1ccccc1.O=C(O)c1ccc(F)cc1F.On1nnc2ccccc21>>NC(=O)[C@@H](NC(=O)[C@@H]1CCCC[C@H]1N1CCN(C(=O)c2ccc(F)cc2F)CC1)c1ccccc1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cc1nn(COCC[Si](C)(C)C)c2cc([N+](=O)[O-])ccc12.[Pd]>>Cc1nn(COCC[Si](C)(C)C)c2cc(N)ccc12",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)C(=O)NC(=O)Nc1ccc(Oc2ccnc(N)c2)cn1.CCN(C(C)C)C(C)C.CN1CCC(C(=O)O)C1.ClCCl.O=C([O-])[O-].O=S(Cl)Cl.[K+].[K+]>>CN1CCC(C(=O)Nc2cc(Oc3ccc(NC(=O)NC(=O)C(C)(C)C)nc3)ccn2)C1",
        "output": "368"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)CN1CCc2ccccc2C1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCN1CCc2ccccc2C1",
        "output": "225"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)[C@H](N)CC(C)C.Cc1cc(C(=O)O)ccc1F>>COC(=O)[C@@H](CC(C)C)NC(=O)c1ccc(F)c(C)c1",
        "output": "652"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCC.Cc1cc(Br)c(Cl)cc1F.O.O=C=O.[Li]CCCC>>Cc1cc(C(=O)O)c(Cl)cc1F",
        "output": "654"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)CCC(C)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>COC(=O)CCC(C)C(=O)N1CCC[C@H]1C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "NC(=O)c1[nH]c2ncccc2c1-c1ccc(N)cc1.O=C=Nc1cccc(C(F)(F)F)c1>>NC(=O)c1[nH]c2ncccc2c1-c1ccc(NC(=O)Nc2cccc(C(F)(F)F)c2)cc1",
        "output": "473"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC1CCCCN1.O=[N+]([O-])c1cnc(Cl)c([N+](=O)[O-])c1>>CC1CCCCN1c1ncc([N+](=O)[O-])cc1[N+](=O)[O-]",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)CC(=O)O.CC[C@@H]1C(=O)N(C)c2cnc(-c3ccncc3N)nc2N1C(C)C.O=C(O)C(F)(F)F>>CC[C@@H]1C(=O)N(C)c2cnc(-c3ccncc3NC(=O)CC(C)(C)C)nc2N1C(C)C",
        "output": "724"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.N#Cc1ccccc1Nc1nc2cnc(-c3cccc(C(=O)O)c3)cn2n1.NC1CCCC1.O>>N#Cc1ccccc1Nc1nc2cnc(-c3cccc(C(=O)NC4CCCC4)c3)cn2n1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.Cc1ccccc1.O.O=S(Cl)Cl.OCc1ccc(Br)nc1.[Na+].[OH-]>>ClCc1ccc(Br)nc1",
        "output": "477"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCI.COc1ccc(-c2nc(CCC(=O)c3ccccc3OC(F)F)co2)cc1O>>CCOc1cc(-c2nc(CCC(=O)c3ccccc3OC(F)F)co2)ccc1OC",
        "output": "198"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)C1CN(C(=O)OCc2ccccc2)C2CCN(C(=O)OC(C)(C)C)C12.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC2C1C(C(=O)O)CN2C(=O)OCc1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCNCc1ccccc1.COc1ccccc1N(CC(=O)O)S(=O)(=O)c1ncccc1C>>CCN(Cc1ccccc1)C(=O)CN(c1ccccc1OC)S(=O)(=O)c1ncccc1C",
        "output": "633"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CCCBr.CN(C)C=O.O=[N+]([O-])c1ccccc1O.[H-].[Na+]>>CCOC(=O)CCCOc1ccccc1[N+](=O)[O-]",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CO.COC(=O)CC1(C2CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)C=CC=CC1.[Na+].[OH-]>>COc1ccc(CC2c3cc(OC)c(OC)cc3CCC2C2(CC(=O)O)C=CC=CC2)cc1OC",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCCCC1CC(=O)O.[Cl-].[NH4+]>>CC(C)(C)OC(=O)N1CCCCC1CC(N)=O",
        "output": "313"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.CN(C)S(=O)(=O)c1cc(F)ccc1CBr.O.[C-]#N.[Na+]>>CN(C)S(=O)(=O)c1cc(F)ccc1CC#N",
        "output": "39"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)CSc1cccc(CO)c1.CCOC(C)=O.ClCCl.O=S(Cl)Cl>>CC(C)CSc1cccc(CCl)c1",
        "output": "81"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(=O)(=O)Cl.ClCCl.NCc1ccc(Br)c(Cl)c1.c1ccncc1>>CS(=O)(=O)NCc1ccc(Br)c(Cl)c1",
        "output": "742"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1cc(CNS(C)(=O)=O)ccc1N.Cl.O.O.[Li]O>>CS(=O)(=O)NCc1ccc(N)c(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1ccccc1.Clc1ncc(Br)cn1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].OB(O)c1ccccc1-c1ccccc1.[K+].[K+].[K+].[Pd].[Pd]>>Clc1ncc(-c2ccccc2-c2ccccc2)cn1",
        "output": "871"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NCC1CCCO1.O.O.O=C(O)c1ccc2[nH]nc(-c3ccc(F)cc3)c2c1.On1nnc2ccccc21>>O=C(NCC1CCCO1)c1ccc2[nH]nc(-c3ccc(F)cc3)c2c1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCC.CCO.CCOC(C)=O.CO.COc1ccc(-n2nc(CCC(=O)O)cc2-c2ccc(Cl)cc2)cc1.O=S(=O)(O)O>>CCOC(=O)CCc1cc(-c2ccc(Cl)cc2)n(-c2ccc(OC)cc2)n1",
        "output": "47"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.OCc1cc(N2CCOCC2)nc(-c2ccc3[nH]ccc3c2)n1>>CS(=O)(=O)OCc1cc(N2CCOCC2)nc(-c2ccc3[nH]ccc3c2)n1",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1C(=O)N(Cc2ccc(C(F)(F)F)cc2)CC1CCOc1ccc(CCC(=O)OC(C)(C)C)c(CN2C(=O)c3ccccc3C2=O)c1.ClCCl>>CN1C(=O)N(Cc2ccc(C(F)(F)F)cc2)CC1CCOc1ccc(CCC(=O)O)c(CN2C(=O)c3ccccc3C2=O)c1",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.ClCCl.OCc1ccc2c(c1)NCCO2.[Mn+4].[O-2].[O-2]>>O=Cc1ccc2c(c1)NCCO2",
        "output": "179"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1=COCCC1.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O=C(Nc1ccc(O)cc1)C(F)(F)F.O=C([O-])O.[Na+]>>O=C(Nc1ccc(OC2CCCCO2)cc1)C(F)(F)F",
        "output": "319"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)[C@@H]1CN(C(=O)OCc2ccccc2)C[C@H]1O.O.[Na+].[OH-]>>O=C(O)[C@@H]1CN(C(=O)OCc2ccccc2)C[C@H]1O",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cccc(CO)c1F.Cl.[Na+].[OH-]>>O=C(O)c1cccc(CO)c1F",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.NN.O.O=C(Nc1ccc2c(ccn2CCCN2C(=O)c3ccccc3C2=O)c1)c1nc2ccc(Cl)cc2n1Cc1ccccc1>>NCCCn1ccc2cc(NC(=O)c3nc4ccc(Cl)cc4n3Cc3ccccc3)ccc21",
        "output": "242"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCN=C=O.Cc1ccc(O)c(-c2nnc(C3(c4cccs4)CCCC3)[nH]2)c1.ClC(Cl)Cl>>CCNC(=O)Oc1ccc(C)cc1-c1nnc(C2(c3cccs3)CCCC2)[nH]1",
        "output": "104"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(N)c1ccccc1.CO.Cc1c(Cl)cccc1-c1cc(Cl)nc(N)n1>>Cc1c(Cl)cccc1-c1cc(NC(C)(C)c2ccccc2)nc(N)n1",
        "output": "165"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCOC(=O)C(Cc1ccc(OCCc2ccc(SC)cc2)cc1)OCC>>CCOC(Cc1ccc(OCCc2ccc(SC)cc2)cc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCl.O.O=S(Cl)Cl.OCc1cc(-c2ccnc(Nc3cccc(Cl)c3)n2)ccn1>>ClCc1cc(-c2ccnc(Nc3cccc(Cl)c3)n2)ccn1",
        "output": "594"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)Br.O=C([O-])[O-].Oc1cccc(Br)c1F.[Cs+].[Cs+]>>CC(C)Oc1cccc(Br)c1F",
        "output": "153"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCc1ccccc1.CC(C)(C)O[K].CN(C)C=O.O.O=C1CCCc2c(O)cccc21>>O=C1CCCc2c(OCc3ccccc3)cccc21",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC[C@H]1O[C@@H](c2ccc(C#N)c(Cc3ccc(OCC=O)cc3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.CCO.CON.Cl.c1ccncc1>>CON=CCOc1ccc(Cc2cc([C@@H]3O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(C)=O)ccc2C#N)cc1",
        "output": "118"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CNCC(O)c1ccc(Cl)o1.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCl)sc21.O>>CN(Cc1cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c2s1)CC(O)c1ccc(Cl)o1",
        "output": "639"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)COC(=O)Cl.CC[C@H](C)[C@H](NC(=O)OC(C)C)C(=O)O.CN1CCCCC1.C[C@@H](N)C(=O)Nc1ccc(C#N)cc1.ClCCl.O>>CC[C@H](C)[C@H](NC(=O)OC(C)C)C(=O)N[C@H](C)C(=O)Nc1ccc(C#N)cc1",
        "output": "133"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)c1cc(CCC(=O)O)cc(-n2nc3ccccc3n2)c1O.CO.O=S(=O)(O)O>>COC(=O)CCc1cc(-n2nc3ccccc3n2)c(O)c(C(C)(C)C)c1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.Cl.O=[N+]([O-])c1cccc(C(F)(Cl)C(F)(Cl)Cl)c1>>Nc1cccc(C(F)(Cl)C(F)(Cl)Cl)c1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)NS(=O)(=O)c1ccc(N)cc1.COc1ccc(C=O)cc1F.Cc1ccccc1>>COc1ccc(C=Nc2ccc(S(=O)(=O)NC(C)(C)C)cc2)cc1F",
        "output": "329"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cc(-c2ccc(Cl)c(C)c2)nc(Cl)n1.OB(O)c1cccc(Br)c1>>Cc1cc(-c2ccc(Cl)c(C)c2)nc(-c2cccc(Br)c2)n1",
        "output": "874"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCS3(=O)=O)cc1.COCCOC.Cl>>CCOc1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCS3(=O)=O)cc1",
        "output": "58"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O.N#Cc1cnc(N2CCNCC2)s1>>CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ncc(C#N)s2)CC1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(O[Si](C)(C)C(C)(C)C)n1cc(C(=O)N2CCN(c3cccc(C(N)=O)c3)CC2)c(-c2ccccc2)c1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.[F-]>>CC(O)n1cc(C(=O)N2CCN(c3cccc(C(N)=O)c3)CC2)c(-c2ccccc2)c1",
        "output": "708"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCOCc1ccccc1Oc1ccc2c(c1)C=C(C(=O)OC)CCS2(=O)=O.CO.Cl.O=C([O-])[O-].[K+].[K+]>>CCCOCc1ccccc1Oc1ccc2c(c1)C=C(C(=O)O)CCS2(=O)=O",
        "output": "58"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCN(CC)CC.CS(=O)(=O)Cl.C[C@@H]1CCCN1.ClCCl.O=C([O-])[O-].OCCc1cc2ccc(-c3cccnc3)cc2cn1.[K+].[K+]>>C[C@@H]1CCCN1CCc1cc2ccc(-c3cccnc3)cc2cn1",
        "output": "371"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1nn(C)cc1-c1ccc(F)cc1.O.[Na+].[OH-]>>Cn1cc(-c2ccc(F)cc2)c(C(=O)O)n1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCI.CN(C)C=O.Cc1oc(-c2ccc(Cl)cc2)cc1C(=O)O.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cc(-c2ccc(Cl)cc2)oc1C",
        "output": "196"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.COCOc1cccc(-c2nc(N3CCOCC3)c3ncc(CO)cc3n2)c1.Cl>>OCc1cnc2c(N3CCOCC3)nc(-c3cccc(O)c3)nc2c1",
        "output": "755"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=Cc1cc(N)ccc1N1CCN(C)CC1.CC(C)S(=O)(=O)c1ccc(Br)cc1Nc1nc(Cl)ncc1Cl.COCCO.CS(=O)(=O)O>>C=Cc1cc(Nc2ncc(Cl)c(Nc3cc(Br)ccc3S(=O)(=O)C(C)C)n2)ccc1N1CCN(C)CC1",
        "output": "808"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN.CO.COc1ccc(NC(=O)c2ccc(Cl)nc2)cc1>>CNc1ccc(C(=O)Nc2ccc(OC)cc2)cn1",
        "output": "70"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C(=O)Oc1ccc(N)cn1)c1ccccc1.CN(C)C=O.Cl.O.O=C(O)c1ccc(-n2cncn2)cc1.On1nnc2ccccc21>>CN(C(=O)Oc1ccc(NC(=O)c2ccc(-n3cncn3)cc2)cn1)c1ccccc1",
        "output": "759"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.C=[N+]=[N-].CCOCC.Clc1ccc(CBr)cc1.O=C(O)CC1CCc2c1[nH]c1c(Br)cc(F)cc21.[H-].[Na+]>>O=C(O)CC1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21",
        "output": "528"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCCNC(=O)c1ccc(N)c(OC)c1.CCN(C(C)C)C(C)C.CCOC(C)=O.Cl.FC(F)(F)c1cnc(Cl)nc1Cl>>CCCNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Cl)n2)c(OC)c1",
        "output": "941"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)CCC(=O)c1cccc(-c2ccccc2)c1.O.O.[Li]O>>O=C(O)CCC(=O)c1cccc(-c2ccccc2)c1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1ccc2c(cnn2C2CCCCO2)c1.C#CCC(C)C.CCN(CC)CC.CCOC(C)=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>CC(C)CC#Cc1ccc2c(cnn2C2CCCCO2)c1",
        "output": "659"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCCCOCCOCCOP(=O)([O-])OCCBr.Cc1ccccc1.c1ccnnc1>>CCCCCCCCCCCCOCCOCCOP(=O)([O-])OCC[n+]1ccccn1",
        "output": "577"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.CC(C)(C)OC(=O)CC(O)CCc1ccc(-c2ccccc2)cc1.CN(C)c1ccncc1.Cl.ClCCl.c1ccncc1>>CC(=O)OC(CCc1ccc(-c2ccccc2)cc1)CC(=O)OC(C)(C)C",
        "output": "254"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CNC.COc1cc(C(C)(C)C)ccc1CC(=O)Cl.ClCCl>>COc1cc(C(C)(C)C)ccc1CC(=O)N(C)C",
        "output": "125"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.ClCCl.NC1CCCCC1.O=C(Cl)c1ccc(Br)cc1F>>O=C(NC1CCCCC1)c1ccc(Br)cc1F",
        "output": "271"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.Cc1ccc2c(c1)NC(=O)C(C(C)C)O2.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Mg+2].[Na+].[OH-]>>Cc1ccc2c(c1)NCC(C(C)C)O2",
        "output": "363"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)CC(=O)O.COc1ccc(-c2cc(N3CCC(N)C3)nc(/C=C/c3nc(N(C)C)c4ccccc4n3)n2)cc1OC.Cl.Cl.O=C([O-])O.On1nnc2ccccc21.[Na+]>>COc1ccc(-c2cc(N3CCC(NC(=O)CN(C)C)C3)nc(/C=C/c3nc(N(C)C)c4ccccc4n3)n2)cc1OC",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br.CCN=C=NCCCN(C)C.CCOC(=O)[C@@H]1CCCC[C@@H]1N.CN(C)C=O.CN1CCOCC1.O=C(O)c1cc2ccccc2[nH]1.On1nnc2ccccc21>>CCOC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1cc2ccccc2[nH]1",
        "output": "137"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.COC(=O)CCc1cc(C(=O)c2cccc(C(=O)OC)n2)ccc1OC>>COC(=O)CCc1cc(C(=O)c2cccc(C(=O)OC)n2)ccc1O",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCBr.CCO.O.Oc1ccc2ccccc2c1.[Na+].[OH-]>>CCCCOc1ccc2ccccc2c1",
        "output": "75"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O=C(OO)c1cccc(Cl)c1.[NH4+].[OH-].c1ccc(COc2ccc3c(c2)ncc2nc4n(c23)CCOC4)cc1>>Nc1nc2cc(OCc3ccccc3)ccc2c2c1nc1n2CCOC1",
        "output": "959"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.COc1cc2ncnc(Oc3ccc(OCC(=O)O)cc3)c2cc1OC.Cl.ClC(Cl)Cl.O.O=C([O-])O.On1nnc2ccccc21.[Na+].c1ccc2c(c1)CCNC2>>COc1cc2ncnc(Oc3ccc(OCC(=O)N4CCc5ccccc5C4)cc3)c2cc1OC",
        "output": "633"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.NC1CC1.O=S1(=O)N(CCCCBr)Cc2cc(F)ccc2N1c1ccccc1F>>O=S1(=O)N(CCCCNC2CC2)Cc2cc(F)ccc2N1c1ccccc1F",
        "output": "147"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.CCCCCC.CCN1CC2(CCC2)Cc2cc(OC)c(C)c(C)c21.CCOC(C)=O.ClC(Cl)Cl>>CCN1CC2(CCC2)Cc2cc(O)c(C)c(C)c21",
        "output": "402"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COC(=O)c1cc(C(=O)Cn2nnc(C(F)(F)F)n2)cn1-c1ncccc1Cl.[Na+].[OH-]>>O=C(Cn1nnc(C(F)(F)F)n1)c1cc(C(=O)O)n(-c2ncccc2Cl)c1",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(CC(=O)O)CC1.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.C[Si](C)(C)CCOCn1ccnc1CNCc1nccn1COCC[Si](C)(C)C.O.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCC(CC(=O)N(Cc2nccn2COCC[Si](C)(C)C)Cc2nccn2COCC[Si](C)(C)C)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.O=Cc1cnc2c(c1)CCCC2.[Na+]>>c1nc2c(cc1CN1CCOCC1)CCCC2",
        "output": "757"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrP(Br)Br.Cc1ccccc1.N#Cc1ccccc1-c1ccc(CO)cc1F.O=C([O-])O.[Na+]>>N#Cc1ccccc1-c1ccc(CBr)cc1F",
        "output": "300"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.O=S(=O)(c1ccccc1)n1c2ccc(-c3ccc(CN4CCOCC4)cc3)cc2c2cc(Cl)cnc21.[F-]>>Clc1cnc2[nH]c3ccc(-c4ccc(CN5CCOCC5)cc4)cc3c2c1",
        "output": "831"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CN(C)C=O.Cl.N#Cc1cc(-c2ccccc2)ccc1NC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=S(=O)([O-])O.[K+].[N-]=[N+]=[N-].[Na+]>>O=C(Nc1ccc(-c2ccccc2)cc1-c1nnn[nH]1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "390"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)COC1CCN(C(=O)OC(C)(C)C)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(C)OC(=O)N1CCC(OCCO)CC1",
        "output": "343"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CON.Cl.O=Cc1ccc(F)cc1Cl>>CON=Cc1ccc(F)cc1Cl",
        "output": "30"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC(CC(=O)O)CC1.CC(C)c1cccc(Nc2nc3cc(Oc4ccnc(N)c4)ccc3n2C)c1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)c1ccncc1.F[P-](F)(F)(F)(F)F>>CC(C)c1cccc(Nc2nc3cc(Oc4ccnc(NC(=O)CC5CCN(C(=O)OC(C)(C)C)CC5)c4)ccc3n2C)c1",
        "output": "368"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCc1ccc(N2CCC[C@H]2C(F)(F)F)cc1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.O.[F-]>>OCc1ccc(N2CCC[C@H]2C(F)(F)F)cc1",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cc1ccc(S(=O)(=O)n2c(-c3cn(C)c4ccc(C#N)cc34)cc3cccnc32)cc1.Cl.NO.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(S(=O)(=O)n2c(-c3cn(C)c4ccc(C(=N)NO)cc34)cc3cccnc32)cc1",
        "output": "854"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CSc1ccnc(N)c1.O.O=C(CBr)c1ccc(Br)cc1.O=C([O-])O.[Na+]>>CSc1ccn2cc(-c3ccc(Br)cc3)nc2c1",
        "output": "508"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCCS(=O)(=O)Cl.CCN(CC)CC.Cc1cc(Cl)ccc1-c1nc(N)nc2c1CNC2.Cc1cc(Cl)ccc1B(O)O>>CCCS(=O)(=O)N1Cc2nc(N)nc(-c3ccc(Cl)cc3C)c2C1",
        "output": "584"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)CO.CC(C)C[C@H](NC(=O)Cc1ccccc1)C(=O)O.ClC(Cl)Cl>>CC(C)COC(=O)[C@H](CC(C)C)NC(=O)Cc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.O=C(O)CCC(Br)(Br)Br.O=S(Cl)Cl>>O=C(Cl)CCC(Br)(Br)Br",
        "output": "53"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc2[nH]c(=O)c(C(=O)Nc3cc(C(=O)O)ccc3C)cc2cn1.NCc1ccccc1Cl>>COc1cc2[nH]c(=O)c(C(=O)Nc3cc(C(=O)NCc4ccccc4Cl)ccc3C)cc2cn1",
        "output": "753"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Fc1cccc(OCc2cn3cc(Br)cnc3n2)c1.OB(O)c1ccc(F)cc1C(F)(F)F>>Fc1cccc(OCc2cn3cc(-c4ccc(F)cc4C(F)(F)F)cnc3n2)c1",
        "output": "871"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)NS(=O)(=O)c1ccc(Br)s1.CCO.Cc1ccccc1.N#CCc1ccc(B(O)O)cc1.O.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)NS(=O)(=O)c1ccc(-c2ccc(CC#N)cc2)s1",
        "output": "864"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCSC[C@H](N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O)C(=O)OCC.CCO.[Na+].[OH-]>>CCCCCCSC[C@H](N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O.[H][H].[Na].[Pd]>>Nc1ccc(C[C@H](N)C(=O)O)cc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cc2c(N)cccc2cn1.Cc1ccccc1.O=C=NCc1ccc(Br)cc1>>Cc1cc2c(NC(=O)NCc3ccc(Br)cc3)cccc2cn1",
        "output": "888"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)c1cccc(N(CC(=O)O)S(=O)(=O)c2ccc(C(C)(C)C)cc2)c1.OCCCNCc1ccccn1>>CN(C)c1cccc(N(CC(=O)N(CCCO)Cc2ccccn2)S(=O)(=O)c2ccc(C(C)(C)C)cc2)c1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C(=O)OC(C)(C)C)[C@H](Cc1ccc2ccccc2c1)C(=O)O.CN(C)C=O.CN[C@H](Cc1ccccc1)C(=O)N1CCC(CN(C)C)CC1.Cl.ClCCl.On1nnc2cccnc21>>CN(C)CC1CCN(C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)OC(C)(C)C)CC1",
        "output": "297"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(c1ccc(CO)cc1Cl)C(O)(c1ccnc(Cl)c1)C(F)(F)F.CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl>>CC(c1ccc(COS(C)(=O)=O)cc1Cl)C(O)(c1ccnc(Cl)c1)C(F)(F)F",
        "output": "0"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(c1ccc(C(=O)O)cc1)c1cccc(F)c1.Cl.F[P-](F)(F)(F)(F)F.NCCc1c[nH]c2ccc(Cl)cc12>>CN(c1ccc(C(=O)NCCc2c[nH]c3ccc(Cl)cc23)cc1)c1cccc(F)c1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.Cc1ccc(Cl)cc1-c1nc(Cl)nc(Cl)n1.ClCCl.Nc1ccc(Br)cc1>>Cc1ccc(Cl)cc1-c1nc(Cl)nc(Nc2ccc(Br)cc2)n1",
        "output": "592"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCc1c(OCCCOc2ccc3c(c2CCC)OC(C)(CCC(=O)OC)CC3=O)ccc(C(C)=O)c1O.CO.O.[Li+].[OH-]>>CCCc1c(OCCCOc2ccc3c(c2CCC)OC(C)(CCC(=O)O)CC3=O)ccc(C(C)=O)c1O",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(C)(C)[Si](C)(C)OCc1ccc(C#C[Si](C)(C)C)cc1.CO.CO.[K+].[OH-]>>C#Cc1ccc(CO[Si](C)(C)C(C)(C)C)cc1",
        "output": "337"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.Cc1cccc(C2CCCN2)c1>>Cc1ccc(S(=O)(=O)N2CCCC2c2cccc(C)c2)cc1",
        "output": "900"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.Nc1ccccc1C(F)(F)F.O.O=C(Cl)Oc1ccccc1.c1ccncc1>>O=C(Nc1ccccc1C(F)(F)F)Oc1ccccc1",
        "output": "102"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.O=C1COc2cc(F)ccc2N1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Fc1ccc2c(c1)OCCN2",
        "output": "363"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)O)c(OC)cc3C)c(F)c12.Cl.F[P-](F)(F)(F)(F)F.NC1(c2ncccn2)COC1.O.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5ncccn5)COC4)c(OC)cc3C)c(F)c12",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.Cc1ccc(S(=O)(=O)Cl)cc1.O=C([O-])[O-].Oc1ccc(Br)c(O)c1.[K+].[K+]>>Cc1ccc(S(=O)(=O)Oc2ccc(Br)c(O)c2)cc1",
        "output": "380"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1c1cc(C)nn1C1CCC1.[Li+].[OH-]>>Cc1cc(N2C[C@H](S(=O)(=O)c3ccccc3Cl)C[C@H]2C(=O)O)n(C2CCC2)n1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCC1CC1.CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(O)cc1.[K+].[K+]>>O=[N+]([O-])c1ccc(OCC2CC2)cc1",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(CC=O)CC1.CCN(CC)CC.CO.CSc1ccc(C2CCNCC2)cc1.Cl.[BH4-].[Na+]>>CSc1ccc(C2CCN(CCC3CCN(C(=O)OC(C)(C)C)CC3)CC2)cc1",
        "output": "484"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrBr.CCO.CCOC(=O)c1ccc(CCC(C)=O)cc1>>CCOC(=O)c1ccc(CCC(=O)CBr)cc1",
        "output": "173"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cn1nc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)c2ccc(Cl)cc21.F[B-](F)(F)F.N[C@H]1CCCOC1.O.O=C(O)C(F)(F)F>>Cn1nc(-c2cnc3c(n2)c(C(=O)N[C@H]2CCCOC2)cn3COCC[Si](C)(C)C)c2ccc(Cl)cc21",
        "output": "737"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(-c2[nH]c3ccccc3c2CCNCCc2ccc([N+](=O)[O-])cc2)cc1OC.Cl.[H][H].[OH-].[OH-].[Pd+2]>>COc1ccc(-c2[nH]c3ccccc3c2CCNCCc2ccc(N)cc2)cc1OC",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CC[C@H](C)C(=O)O.O=S(=O)(O)O.[Cl-].[Na+]>>CCOC(=O)[C@@H](C)CC",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CN1CCC(O)CC1.O=C(O)Cc1cnn(-c2ccccc2)c1-c1ccc(Cl)cc1>>CN1CCC(OC(=O)Cc2cnn(-c3ccccc3)c2-c2ccc(Cl)cc2)CC1",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)N(c1ncc(Br)cn1)CC21CC1.O.[Li+].[OH-]>>O=C(O)c1ccc2c(c1)N(c1ncc(Br)cn1)CC21CC1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.COCCOc1ccc2c(c1-c1ncnc3c(C(=O)N[C@@H]4CC[C@@H](N)CC4)c[nH]c13)OCO2>>COCCOc1ccc2c(c1-c1ncnc3c(C(=O)N[C@@H]4CC[C@@H](NC(C)=O)CC4)c[nH]c13)OCO2",
        "output": "45"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "N[C@H]1CCN(CCc2ccc(F)cc2)C1.O=C(O)C1c2ccccc2Sc2ccccc21>>O=C(N[C@H]1CCN(CCc2ccc(F)cc2)C1)C1c2ccccc2Sc2ccccc21",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)CC(CO)NC(=O)OC(C)(C)C.CS(C)=O.O.O=C(O)c1ccccc1I(=O)=O>>CC(C)CC(C=O)NC(=O)OC(C)(C)C",
        "output": "142"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCC.CSC.ClCCl.FB(F)F.N#Cc1c(C(=O)NN2CCCCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(OCc2ccccc2)cc1.O>>N#Cc1c(C(=O)NN2CCCCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(O)cc1",
        "output": "23"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(C)=O.Cl.NCc1cccc(Br)c1.O>>CC(C)(C)OC(=O)NCc1cccc(Br)c1",
        "output": "686"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)=O.N=c1sc2cc(OC(F)(F)F)ccc2n1CCSc1ccncc1.O.O=C(O)C(=O)O.O=C(OO)c1cccc(Cl)c1.O=C([O-])C(=O)[O-]>>N=c1sc2cc(OC(F)(F)F)ccc2n1CCS(=O)c1ccncc1",
        "output": "500"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OCCCCBr.CC1(C)CCC(C)(C)c2cc(-c3cccc(N4CCNCC4)n3)ccc21.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CC(=O)OCCCCN1CCN(c2cccc(-c3ccc4c(c3)C(C)(C)CCC4(C)C)n2)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=C(O)c1ccc([N+](=O)[O-])c(C(=O)O)c1.[Pd]>>Nc1ccc(C(=O)O)cc1C(=O)O",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1CCNCC1=O.O=C(N[C@H]1CC[C@@H](C(=O)O)C1)c1ccc(-c2cccc(F)c2)nc1>>CN1CCN(C(=O)[C@@H]2CC[C@H](NC(=O)c3ccc(-c4cccc(F)c4)nc3)C2)CC1=O",
        "output": "297"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cl[Sn]Cl.O=[N+]([O-])c1ccc(Oc2ccc(F)c(Cl)c2)nc1>>Nc1ccc(Oc2ccc(F)c(Cl)c2)nc1",
        "output": "269"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)CC1.O.OC1(c2cc(Cl)nc(C(F)(F)F)c2)COC1.[Cl-].[H-].[NH4+].[Na+]>>CC(C)(C)OC(=O)N1CCC(Oc2cc(C3(O)COC3)cc(C(F)(F)F)n2)CC1",
        "output": "433"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CNCCN1.CC#N.CCN(C(C)C)C(C)C.CS(=O)(=O)c1ccc(F)cc1NC1CCOc2ccccc21>>CS(=O)(=O)c1ccc(N2CCNCC2)cc1NC1CCOc2ccccc21",
        "output": "26"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1CC2CCC(C1)C2N.ClCCl.O=S(=O)(Cl)c1ccc(Cl)s1.c1ccncc1>>CC1CC2CCC(C1)C2NS(=O)(=O)c1ccc(Cl)s1",
        "output": "600"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(=O)(=O)Cl.ClCCl.Cn1cc(-c2ccc3c(=O)n(C)cc(-c4cc(N)ccc4F)c3c2)cn1.c1ccncc1>>Cn1cc(-c2ccc3c(=O)n(C)cc(-c4cc(NS(C)(=O)=O)ccc4F)c3c2)cn1",
        "output": "194"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(CC)(c1ccc(OCC(=O)C(C)(C)C)c(C)c1)c1cc2cc(O)ccc2s1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CCC(CC)(c1ccc(OCC(=O)C(C)(C)C)c(C)c1)c1cc2cc(OS(C)(=O)=O)ccc2s1",
        "output": "149"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)Oc1cc(Oc2ccc3c(c2)OCCN(C)C3=O)cc(C(=O)Nc2ccn(C(=O)OC(C)(C)C)n2)c1.CO>>CC(C)Oc1cc(Oc2ccc3c(c2)OCCN(C)C3=O)cc(C(=O)Nc2cc[nH]n2)c1",
        "output": "896"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.Clc1ncnc2c1CN(Cc1ccccc1)CC2.Nc1ccc(F)cc1>>Fc1ccc(Nc2ncnc3c2CN(Cc2ccccc2)CC3)cc1",
        "output": "352"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cl.O=C(Cl)c1ccc(F)c([N+](=O)[O-])c1.[Al+3].[Cl-].[Cl-].[Cl-].c1ccccc1>>O=C(c1ccccc1)c1ccc(F)c([N+](=O)[O-])c1",
        "output": "61"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C=C(CCNS(=O)(=O)c1ccccc1Cl)c1c(C)c(CC(=O)OC)cc2ccc(F)cc12.O.[Li+].[OH-]>>C=C(CCNS(=O)(=O)c1ccccc1Cl)c1c(C)c(CC(=O)O)cc2ccc(F)cc12",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.COc1ccc2c([N+](=O)[O-])cccc2n1.[H][H].[Pd]>>COc1ccc2c(N)cccc2n1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[O-].CN(C)C=O.COc1cccc2c1CCCC2CCBr.O=c1ccc(C(c2ccccc2)c2ccccc2)n[nH]1.[K+]>>COc1cccc2c1CCCC2CCn1nc(C(c2ccccc2)c2ccccc2)ccc1=O",
        "output": "577"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.COC(=O)Cc1c[nH]c2ccccc12.[H-].[Na+]>>COC(=O)Cc1cn(C)c2ccccc12",
        "output": "191"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C=CCC(COc1ccc(F)cc1)OCc1ccccc1.O.OO.[BH4-].[B].[Na+].[Na+].[OH-]>>OCCCC(COc1ccc(F)cc1)OCc1ccccc1",
        "output": "465"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.C[C@@H]1CCc2ncnc(N3CC4(CCN(C(=O)OC(C)(C)C)CC4)c4cc(CC(=O)O)ccc43)c21.ClCCl.ClCCl.F[P-](F)(F)(F)(F)F.[Cl-].[NH4+]>>C[C@@H]1CCc2ncnc(N3CC4(CCN(C(=O)OC(C)(C)C)CC4)c4cc(CC(N)=O)ccc43)c21",
        "output": "313"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.O=C1COc2cccnc2N1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>c1cnc2c(c1)OCCN2",
        "output": "363"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(C)=O.Cc1ncc(Oc2ccc(C#N)cn2)c2ccccc12.O.O=C([O-])[O-].OO.[K+].[K+]>>Cc1ncc(Oc2ccc(C(N)=O)cn2)c2ccccc12",
        "output": "677"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)(C)OC(=O)CCCSc1nc2cc[nH]c2c(=O)n1-c1ccc(OCC(F)(F)F)cc1.Cl>>O=C(O)CCCSc1nc2cc[nH]c2c(=O)n1-c1ccc(OCC(F)(F)F)cc1",
        "output": "278"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1cc[nH]n1.CN(C)[C@@H]1CCCC[C@H]1N.Cc1ccccc1.Fc1ccc(I)cc1.O=C([O-])[O-].[Cu]I.[K+].[K+]>>CCOC(=O)c1ccn(-c2ccc(F)cc2)n1",
        "output": "901"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O=C(O)CCCCCCCn1c(-c2ccccc2)nc(-c2ccccc2)c1-c1ccccc1.O=S(=O)(O)O>>COC(=O)CCCCCCCn1c(-c2ccccc2)nc(-c2ccccc2)c1-c1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Br.C1COCCO1.CC1(c2ccccc2)CCNCC1.NCCCBr.O=C([O-])[O-].[K+].[K+]>>CC1(c2ccccc2)CCN(CCCN)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CO)c(C(F)(F)F)c1.CS(=O)(=O)Cl.ClCCl.O>>CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(COS(C)(=O)=O)c(C(F)(F)F)c1",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=O.CC(C)Cn1c(=O)n(C)c(=O)c2c(Nc3ccccc3)n(Cc3ccc(C4CCCCN4)cc3)nc21.ClCCl.O=S(=O)([O-])[O-].[BH3-]C#N.[Na+].[Na+].[Na+]>>CC(C)Cn1c(=O)n(C)c(=O)c2c(Nc3ccccc3)n(Cc3ccc(C4CCCCN4C)cc3)nc21",
        "output": "69"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)c1cc(OCCF)cc(C(C)(C)C)c1.CO.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.O.[Br-].[Br-].[Br-]>>CC(C)(C)c1cc(OCCF)cc(C(=O)CBr)c1",
        "output": "360"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccccc1OC.O=C(Cl)c1ccc(Cl)cc1>>COc1ccc(C(=O)c2ccc(Cl)cc2)cc1OC",
        "output": "61"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1nc(C)oc1-c1ccc(C)c(C)c1.COC(=O)c1nc(N(C)C)sc1-c1cccc(OC)c1>>Cc1nc(C(=O)O)c(-c2ccc(C)c(C)c2)o1",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.N#Cc1ccc2[nH]c3c(c2c1)CC(N1C(=O)c2ccccc2C1=O)C3.NN.O>>N#Cc1ccc2[nH]c3c(c2c1)CC(N)C3",
        "output": "242"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCN(CCCN2CCNCC2)CC1.CN(C)C=O.ClCCl.O=C=Nc1ccc(Cl)c(Cl)c1>>O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(CCCN2CCCCC2)CC1",
        "output": "323"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCC(n2cc(Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)nn2)CC1.CO.Cl.O>>O=C(Nc1cn(Cc2cn(C3CCNCC3)nn2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCNS(=O)(=O)Cc1ccc([N+](=O)[O-])cc1.CCO.O=[Pd].[H][H]>>CCNS(=O)(=O)Cc1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.COc1cccc2c1nc(N)n1nc(CCOS(=O)(=O)c3ccc(C)cc3)nc21.Cc1nc2c(o1)CNC2.ClCCl.O>>COc1cccc2c1nc(N)n1nc(CCN3Cc4nc(C)oc4C3)nc21",
        "output": "429"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CNc1nc(NCC(=O)OCC)c([N+](=O)[O-])c(C(=O)OCC)n1.CCOC(=O)c1nc(Nc2cccc(O)c2)nc(Nc2cccc(O)c2)c1N.[H][H].[Pd]>>CCOC(=O)CNc1nc(NCC(=O)OCC)c(N)c(C(=O)OCC)n1",
        "output": "660"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.O=C(NC(Cc1cc(=O)[nH]c2ccccc12)C(=O)O)c1ccc(Cl)cc1>>O=C(NC(Cc1cc(=O)[nH]c2ccccc12)C(=O)OCc1ccccc1)c1ccc(Cl)cc1",
        "output": "403"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CI.Clc1ncc(Cl)c(-c2c[nH]c3ccccc23)n1.O.[H-].[Na+]>>Cn1cc(-c2nc(Cl)ncc2Cl)c2ccccc21",
        "output": "191"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.COC(=O)C=Cc1ccc(CN)cc1.O.O=C(NC1CC1)/C(=C/c1ccc(C(=O)O)cc1)c1ccc(F)cc1.On1nnc2ccccc21>>COC(=O)C=Cc1ccc(CNC(=O)c2ccc(/C=C(/C(=O)NC3CC3)c3ccc(F)cc3)cc2)cc1",
        "output": "753"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.Cc1cccc(N)c1.ClCCCl.Nc1ccccc1C(=O)O.On1nnc2ccccc21>>Cc1cccc(NC(=O)c2ccccc2N)c1",
        "output": "50"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(O)Cn1c(COCc2ccccc2)nc(C(C)C)c1Sc1cc(Cl)cc(Cl)c1.Cl.O=C([O-])O.[Na+]>>CC(O)Cn1c(CO)nc(C(C)C)c1Sc1cc(Cl)cc(Cl)c1",
        "output": "178"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCN(Cc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>OC(c1ccc(CN2CCNCC2)cc1)(C(F)(F)F)C(F)(F)F",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCOc1ccc(-n2nc(C(=O)OCC)c(-c3ccc(C(=O)OC(C)(C)C)cc3C(=O)N3CCc4ccccc4C3)c2CCCC)cc1.CCCCc1c(-c2ccc(C(=O)O)cc2C(=O)N2CCc3ccccc3C2)c(C(=O)OCC)nn1-c1ccccc1>>C=CCOc1ccc(-n2nc(C(=O)OCC)c(-c3ccc(C(=O)O)cc3C(=O)N3CCc4ccccc4C3)c2CCCC)cc1",
        "output": "752"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)Cc1csc(N)n1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)C(CC1CCCC1)c1ccc(Cl)cc1>>CCOC(=O)Cc1csc(NC(=O)C(CC2CCCC2)c2ccc(Cl)cc2)n1",
        "output": "681"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cnn(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)c1.O.[Na+].[OH-]>>O=C(O)c1cnn(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)c1",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COc1ccc(Br)c(C)n1.Cc1ccccc1.N#Cc1cccc(B(O)O)c1.O=C([O-])[O-].[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(-c2cccc(C#N)c2)c(C)n1",
        "output": "833"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)COCCN1.CCN(C(C)C)C(C)C.COc1cc2c(cc1CC(C)C)-n1c(Br)nc(C(=O)O)c1CC2.ClCCl>>COc1cc2c(cc1CC(C)C)-n1c(Br)nc(C(=O)N3CCOCC3(C)C)c1CC2",
        "output": "729"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1CCN(c2cncc([N+](=O)[O-])c2N)CC1.CO.[Pd]>>CN1CCN(c2cncc(N)c2N)CC1",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CC[C@@H](C)N.COC(=O)c1ccc2[nH]c(=O)c(Cl)nc2c1.CS(C)=O>>CC[C@@H](C)Nc1nc2cc(C(=O)OC)ccc2[nH]c1=O",
        "output": "148"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)CN1C(=O)C2(COc3cc4c(cc32)CCO4)c2c(Br)cccc21.CCOC(=O)CN1C(=O)C2(COc3cc4c(cc32)OCO4)c2ccccc21>>O=C(O)CN1C(=O)C2(COc3cc4c(cc32)CCO4)c2c(Br)cccc21",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C(=O)O)c1cc(Cl)cc(Br)c1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C(=O)Cl)c1cc(Cl)cc(Br)c1",
        "output": "56"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)C(CC1CCCC1)c1ccc(C#N)cc1.Cl.O.[Li+].[OH-]>>N#Cc1ccc(C(CC2CCCC2)C(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccsc1C(=O)O.Nc1ccc(I)cc1.O=C(O)c1ccc2ccccc2c1>>Cc1ccsc1C(=O)Nc1ccc(I)cc1",
        "output": "822"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)Cn1[nH]c(=O)c2cc([N+](=O)[O-])ccc21.CCOC(C)=O.Cl.[Na+].[OH-]>>O=C(O)Cn1[nH]c(=O)c2cc([N+](=O)[O-])ccc21",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N1CCNCC1.COc1ccc(CN(Cc2ccc(OC)cc2)c2ncc(-c3nc(N4CCOCC4)nc4c3CCN4c3ccc(Cl)nc3)cn2)cc1.COc1ccc(CN(Cc2ccc(OC)cc2)c2ncc(-c3nc(N4CCOCC4)nc4c3CCN4c3ccnc(Cl)c3)cn2)cc1>>COc1ccc(CN(Cc2ccc(OC)cc2)c2ncc(-c3nc(N4CCOCC4)nc4c3CCN4c3ccnc(N4CCN(C(C)=O)CC4)c3)cn2)cc1",
        "output": "220"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(N2CCC(O)CC2)CC1.CC(C)(C)[O-].ClCCl.Fc1ccc(Cl)c(Cl)c1.O=C([O-])O.[K+].[Na+]>>CC(C)(C)OC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1",
        "output": "485"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.O=C(O)CN1CC(c2ccc(Cl)cc2)CC1=O.O=C1CNCCN1.c1ccc(OP(Oc2ccccc2)Oc2ccccc2)cc1>>O=C1CN(C(=O)CN2CC(c3ccc(Cl)cc3)CC2=O)CCN1",
        "output": "297"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.O=C(c1ccccc1)N1CCN(c2ccc(OC[C@H]3CCCNC3)cc2)CC1>>CC(C)N1CCC[C@H](COc2ccc(N3CCN(C(=O)c4ccccc4)CC3)cc2)C1",
        "output": "187"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CC(C)(C)c1cc(C(=O)O)cc(C(C)(C)C)c1O.CCN(CC)CC.Cl.NCc1ccc([N+](=O)[O-])cc1>>CC(C)(C)c1cc(C(=O)NCc2ccc([N+](=O)[O-])cc2)cc(C(C)(C)C)c1O",
        "output": "753"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1cncc(N2CC3CC4CC2CN(C4)C3)c1.OB(O)c1cccc(F)c1>>Fc1cccc(-c2cncc(N3CC4CC5CC3CN(C5)C4)c2)c1",
        "output": "833"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(-c2cccc(C(F)(F)F)c2)nc1Cl.O.O=C([O-])[O-].OB(O)c1ccc(Cl)cc1.[K+].[K+]>>CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(-c2cccc(C(F)(F)F)c2)nc1-c1ccc(Cl)cc1",
        "output": "865"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(O)(c1cccc(Cl)c1)c1ccccc1O.CCCO.CCN(CC)C(=O)CCl.O=C([O-])[O-].[K+].[K+]>>CCN(CC)C(=O)COc1ccccc1C(O)(CC)c1cccc(Cl)c1",
        "output": "458"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.Cl[Sn]Cl.Nc1ccc(S(=O)(=O)c2ccccc2)cc1.O.O.O.O=N[O-].[Na+].[Na+].[OH-]>>NNc1ccc(S(=O)(=O)c2ccccc2)cc1",
        "output": "109"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOc1cc(N(Cc2cncnc2)c2ccc(C(=O)OC(C)(C)C)cc2)ccc1OC(F)F.[K+].[OH-]>>CCOc1cc(N(Cc2cncnc2)c2ccc(C(=O)O)cc2)ccc1OC(F)F",
        "output": "752"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COc1cc2ncc(C(=O)O)c(Nc3cccc(Br)c3)c2cc1OC.N>>COc1cc2ncc(C(N)=O)c(Nc3cccc(Br)c3)c2cc1OC",
        "output": "704"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)NC(=O)n1nc(NCC(=O)NC2CNC2)c2cc(C(F)(F)F)ccc21.O=C1CCC(C2CCCCC2)CC1>>CC(C)NC(=O)n1nc(NCC(=O)NC2CN(C3CCC(C4CCCCC4)CC3)C2)c2cc(C(F)(F)F)ccc21",
        "output": "187"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCC(C)c1c(Cl)nc(-n2cccn2)nc1NCC(F)(F)F.O.O=C1CCC(=O)N1Cl>>CCC(C)c1c(Cl)nc(-n2cc(Cl)cn2)nc1NCC(F)(F)F",
        "output": "856"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COCCOc1cc2ncnc(Cl)c2cc1OCCOC.O=C(O)Cc1ccc(O)c(F)c1>>COCCOc1cc2ncnc(Oc3ccc(CC(=O)O)cc3F)c2cc1OCCOC",
        "output": "890"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cl.NO.O=C([O-])[O-].O=Cc1ccc(F)cc1.[Na+].[Na+]>>ON=Cc1ccc(F)cc1",
        "output": "30"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1cc2c(Cl)ncnc2cc1OCCCN1CCCC1.Cc1[nH]c2ccc(O)cc2c1C.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(Oc3ccc4[nH]c(C)c(C)c4c3)ncnc2cc1OCCCN1CCCC1",
        "output": "668"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.Cc1cc(C)c(S(=O)(=O)c2ccc(O)cc2)c(C)c1.OC1CCCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(C)c(S(=O)(=O)c2ccc(OC3CCCCC3)cc2)c(C)c1",
        "output": "846"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)N1CC(C(O)(Oc2ccc3c(c2)CCC3)c2ccccc2)OCC1=O.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC(C)N1CCOC(C(O)(Oc2ccc3c(c2)CCC3)c2ccccc2)C1",
        "output": "363"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COc1cc(OCCN(CCN2CCOCC2)C(=O)OC(C)(C)C)c(Cl)cc1[N+](=O)[O-].[Cl-].[NH4+].[Zn]>>COc1cc(OCCN(CCN2CCOCC2)C(=O)OC(C)(C)C)c(Cl)cc1N",
        "output": "202"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CCOC(C)=O.Cc1ccccc1.O=[Mn]=O.OCc1ccccc1CC=Cc1cccc(OCc2ccc3ccc(Cl)cc3n2)c1>>O=Cc1ccccc1CC=Cc1cccc(OCc2ccc3ccc(Cl)cc3n2)c1",
        "output": "179"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)C2CC[C@@]1(CS(=O)(=O)O)C(=O)C2.CCCCCC.CCO.CCOC(C)=O.CCOCC.CN(C)C1CN(C2CCN(C(=O)Nc3cc(Oc4ccc(N)cc4F)ccn3)CC2)C1.Cc1ccccc1.O=C(Cc1ccccc1)N=C=S.O=C([O-])O.[Na+]>>CN(C)C1CN(C2CCN(C(=O)Nc3cc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4F)ccn3)CC2)C1",
        "output": "961"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Cl[Sn](Cl)(Cl)Cl.O.O.O=[N+]([O-])c1ccc(-c2cn3cc(Br)ccc3n2)cc1>>Nc1ccc(-c2cn3cc(Br)ccc3n2)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.FC(F)(F)c1nnc2ccc(Cl)nn12.Oc1ccc(C2(O)CCNCC2)cc1>>Oc1ccc(C2(O)CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CCOCC.N#CCN.O.O=C(Cl)c1ccnc(F)c1.O=S(=O)(O)O.[Na+].[OH-]>>N#CCNC(=O)c1ccnc(F)c1",
        "output": "271"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.NCCCCCO.O=C(Cl)OCc1ccccc1>>O=C(NCCCCCO)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)NC(C)C.CCc1ccc(S(=O)(=O)Nc2ccc(F)cc2F)cc1.CN(C)C=O.[Li]CCCC>>CCc1ccc(S(=O)(=O)Nc2ccc(F)c(C=O)c2F)cc1",
        "output": "239"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)n1ccc2c(N)cccc21.O=C([O-])Cc1nc(N2CCOCC2)cc(=O)[nH]1.[Na+]>>CC(C)(C)OC(=O)n1ccc2c(NC(=O)Cc3nc(N4CCOCC4)cc(=O)[nH]3)cccc21",
        "output": "891"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.O.O=C(Nc1nc2ccccc2[nH]1)OCC(Cl)(Cl)Cl.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>O=C(Nc1nc2ccccc2[nH]1)N1CCN(c2nc(-c3ccccc3)ns2)CC1",
        "output": "980"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COc1ccc(CC(C)=O)cc1NC(C)=O.[BH4-].[Na+]>>COc1ccc(CC(C)O)cc1NC(C)=O",
        "output": "91"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNC1.COc1cc(Nc2ncnc3[nH]nc(OCCOS(C)(=O)=O)c23)ccc1OCc1ccccn1>>COc1cc(Nc2ncnc3[nH]nc(OCCN4CCCC4)c23)ccc1OCc1ccccn1",
        "output": "496"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCCSc1nc(Cl)c([N+](=O)[O-])c(N[C@@H]2C[C@H](OCCO)[C@H]3OC(C)(C)O[C@@H]23)n1.CCO.O.[Fe]>>CCCSc1nc(Cl)c(N)c(N[C@@H]2C[C@H](OCCO)[C@H]3OC(C)(C)O[C@@H]23)n1",
        "output": "660"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N(Cc1nc2c(N3CCN(C)CC3)cccc2[nH]1)[C@H]1CCCc2cccnc21.CCCN[C@H]1CCCc2cccnc21.CN1CCN(c2cccc3[nH]c(C=O)nc23)CC1>>CCCN(Cc1nc2c(N3CCN(C)CC3)cccc2[nH]1)[C@H]1CCCc2cccnc21",
        "output": "944"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NCC(=O)N1CC=C(c2cccc(NC(=O)c3cccc(C(F)(F)F)c3)c2)n2nccc21.Cl.ClCCl>>NCC(=O)N1CC=C(c2cccc(NC(=O)c3cccc(C(F)(F)F)c3)c2)n2nccc21",
        "output": "431"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCN(c1nc(C)cc(CO)n1)c1ccc(C(C)C)cc1Br.CS(=O)(=O)Cl.ClCCl>>CCN(c1nc(C)cc(COS(C)(=O)=O)n1)c1ccc(C(C)C)cc1Br",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC[C@H](C)Oc1nc(N)c2nc(OC)n(CCCCCCl)c2n1.CCC[C@H](C)Oc1nc(N)c2nc(OC)n(CCCCNC3CCOCC3)c2n1.NCC1CCOCC1>>CCC[C@H](C)Oc1nc(N)c2nc(OC)n(CCCCCNCC3CCOCC3)c2n1",
        "output": "279"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=Cc1ccn(-c2ccccc2)c1.[BH3-]C#N.[Na+].c1ccc(CC2CCNCC2)cc1>>c1ccc(CC2CCN(Cc3ccn(-c4ccccc4)c3)CC2)cc1",
        "output": "757"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN(C)C=O.CO.COc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)C2Cc3ccccc3C2)C2CC2)C(=O)OCc2ccccc2)cc1.[OH-].[OH-].[Pd+2]>>COc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)C2Cc3ccccc3C2)C2CC2)C(=O)O)cc1",
        "output": "186"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.CN(C)C(OC(C)(C)C)OC(C)(C)C.Cc1ccccc1.O=C(O)c1ccc2ccccc2c1O>>CC(C)(C)OC(=O)c1ccc2ccccc2c1O",
        "output": "768"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)COc1ccc(CCC2Cc3ccc(OC)cc3O2)cc1.COC(=O)CN(C)Cc1ccc(-c2ccc(CN(c3ccc(F)cc3)C(C)C)s2)cc1>>CC(C)N(Cc1ccc(-c2ccc(CN(C)CCO)cc2)s1)c1ccc(F)cc1",
        "output": "343"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CN(c1nc(Cl)ncc1Cl)C1CCC2(CCCN(C(=O)OC(C)(C)C)C2)C1.Cl.Cn1cc(N)cn1>>CN(c1nc(Nc2cnn(C)c2)ncc1Cl)C1CCC2(CCCN(C(=O)OC(C)(C)C)C2)C1",
        "output": "992"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)O.CCN=C=NCCCN(C)C.CN(CCCN)S(=O)(=O)c1ccccc1C#N.CN1CCOCC1.Cl.ClCCl.O=c1c2ccccc2nnn1O>>CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)NCCCN(C)S(=O)(=O)c1ccccc1C#N",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)c1cc(NC(=O)NC2CN(C(=O)CC(C)(C)C)c3ccc(C)cc3N(CC(=O)c3ccccc3C)C2=O)ccc1C.O.[Li+].[OH-]>>Cc1ccc2c(c1)N(CC(=O)c1ccccc1C)C(=O)C(NC(=O)Nc1ccc(C)c(C(=O)O)c1)CN2C(=O)CC(C)(C)C",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)(C)OC(=O)NC1CNC1.CC(C)(C)c1nc2cc(S(=O)(=O)Cl)ccc2n1CC1CCC(F)(F)CC1.CN(C)c1ccncc1>>CC(C)(C)OC(=O)NC1CN(S(=O)(=O)c2ccc3c(c2)nc(C(C)(C)C)n3CC2CCC(F)(F)CC2)C1",
        "output": "99"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC2CCC(C1)N2CCOc1ccc(C#N)cc1.CCOC(C)=O.Cl>>N#Cc1ccc(OCCN2C3CCC2CNC3)cc1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.COC(=O)Cc1ccc(O)cc1F.COCc1cnc(N2CCC([C@H]3C[C@H]3CCO)CC2)nc1.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)OC)c(F)c3)CC2)nc1",
        "output": "478"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cl.Cl.N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O.O.O=C(Cl)C(Cl)(Cl)Cl.O=C([O-])O.[Na+]>>O=C(N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O)C(Cl)(Cl)Cl",
        "output": "45"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1ccc2c(c1)B(O)OC2.O=C(O)CCCOCc1ccccc1>>O=C(CCCOCc1ccccc1)Nc1ccc2c(c1)B(O)OC2",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2CNC2CC2)cc1)C(F)(F)F.CCN(C(C)C)C(C)C.CN(C)c1ccncc1.CS(=O)(=O)Cl.ClCCl>>CC(O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2CN(C2CC2)S(C)(=O)=O)cc1)C(F)(F)F",
        "output": "584"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN1CCNCC1.ClCCl.O=Cc1ccc([N+](=O)[O-])cc1.[Na+]>>CN1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1",
        "output": "567"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)Nc1cc(-c2cn(-c3ccc4nnc(N)n4n3)nc2-c2ccc(F)cc2)ccn1.CC(C)(C)OC(=O)Nc1cc(-c2cn(-c3ccc4nncn4n3)nc2-c2ccccc2)ccn1>>Nc1cc(-c2cn(-c3ccc4nnc(N)n4n3)nc2-c2ccc(F)cc2)ccn1",
        "output": "885"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.CO.COc1cc(-c2csc3c(-c4ccc(C=O)cc4)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C.O=C([O-])[O-].[BH4-].[Na+].[Na+].[Na+]>>COc1cc(-c2csc3c(-c4ccc(CO)cc4)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C",
        "output": "356"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)CN1C(=O)C(NC(=O)c2cc3cc(Cl)sc3[nH]2)Cc2ccccc21.O.[Li+].[OH-]>>O=C(O)CN1C(=O)C(NC(=O)c2cc3cc(Cl)sc3[nH]2)Cc2ccccc21",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C1CCC(O)(c2ncc(-c3cc(C)cc(N(C(=O)OC(C)(C)C)c4nccc(C(F)(F)F)n4)c3)s2)CC1.CI.CN(C)C=O.[H-].[Na+]>>CCOC(=O)C1CCC(OC)(c2ncc(-c3cc(C)cc(N(C(=O)OC(C)(C)C)c4nccc(C(F)(F)F)n4)c3)s2)CC1",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCCN.Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)O)cn1>>Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)NCCNC(=O)OC(C)(C)C)cn1",
        "output": "674"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1ccc(-c2ccn3c(C(=O)Nc4cc(C(=O)NCc5ccc(F)c(F)c5)ccc4F)cnc3c2)cc1F.[Na+].[OH-]>>O=C(NCc1ccc(F)c(F)c1)c1ccc(F)c(NC(=O)c2cnc3cc(-c4ccc(C(=O)O)c(F)c4)ccn23)c1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1ccc(-c2nocc2C(=O)O)cc1Cl.Cc1ccc(C2(O)CCNC2)nc1.Cl.Cl.F[B-](F)(F)F>>COc1ccc(-c2nocc2C(=O)N2CCC(O)(c3ccc(C)cn3)C2)cc1Cl",
        "output": "975"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCl.O=C(O)Cc1cccs1.O=S(Cl)Cl>>O=C(Cl)Cc1cccs1",
        "output": "53"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CCO.CCOC(=O)c1cn([C@@H](C)COC(C)=O)c2c(F)c(N3CCN(C)CC3)c(F)cc2c1=O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cn([C@@H](C)CO)c2c(F)c(N3CCN(C)CC3)c(F)cc2c1=O",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.O=[N+]([O-])c1ccc(N2CCOCC2)nc1.[Pt]>>Nc1ccc(N2CCOCC2)nc1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(C)=O.FC(F)(F)c1cc(Br)ccc1CBr.O.[C-]#N.[K+]>>N#CCc1ccc(Br)cc1C(F)(F)F",
        "output": "39"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.COc1ccc(CN(C(=O)C(Cc2c(C)cc(C(N)=O)cc2C)NC(=O)OC(C)(C)C)C(C)c2nc(-c3ccccc3)c[nH]2)cc1C(=O)O.Cl.O.[Na+].[OH-]>>COc1ccc(CN(C(=O)C(N)Cc2c(C)cc(C(N)=O)cc2C)C(C)c2nc(-c3ccccc3)c[nH]2)cc1C(=O)O",
        "output": "431"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.N#CCC(=O)O.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3F)cc1)nn2C[C@H]1CCCN1.O=C(n1ccnc1)n1ccnc1>>N#CCC(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3F)cc2)c2c(N)ncnc21",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(C)cc(CC(O)C(=O)O)c1.O=S(Cl)Cl>>Cc1cc(C)cc(CC(O)C(=O)Cl)c1",
        "output": "53"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CN(C)C=O.NCc1ccc(Cl)cc1.O=C(O)c1cnc2sc(Br)cc2c1O.O=C(n1ccnc1)n1ccnc1>>O=C(NCc1ccc(Cl)cc1)c1cnc2sc(Br)cc2c1O",
        "output": "790"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)CCCCCOc1ccccc1CN(C(=O)c1ccc(F)cc1)C(C)C.Cl.O.O.[Li+].[OH-]>>CC(C)N(Cc1ccccc1OCCCCCC(=O)O)C(=O)c1ccc(F)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)cc1F.O=C=Nc1cc(C(F)(F)F)ccc1F>>O=C(Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)cc1F)Nc1cc(C(F)(F)F)ccc1F",
        "output": "912"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C1CCN(c2ccnc(N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC3(C(F)(F)F)C=NC(NCCCC4CCCC4)=CC3)n2)CC1.CCOC(C)=O.Cl.[Na+].[OH-]>>O=C(O)C1CCN(c2ccnc(N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC3(C(F)(F)F)C=NC(NCCCC4CCCC4)=CC3)n2)CC1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)c1cc(-c2ccccc2)n(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)c1.CCOC(C)=O.Cc1ccccc1.Cl.[H-]>>O=S(=O)(c1ccc(OC(F)(F)F)cc1)n1cc(CO)cc1-c1ccccc1",
        "output": "383"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.NC1CCCc2c1[nH]c1ccccc21.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)NC1CCCc2c1[nH]c1ccccc21",
        "output": "35"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)N(NC(=O)c1ccccc1)C(=O)CCc1ccccc1Br.CC(C)c1cccc(B(O)O)c1.COCCOC>>CC(C)c1cccc(-c2ccccc2CCC(=O)N(NC(=O)c2ccccc2)C(C)C)c1",
        "output": "837"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCc1cc(NCc2ccccc2)c([N+](=O)[O-])c(N(Cc2ccc(OC)cc2)Cc2ccc(OC)cc2)n1.CO.ClCCl.Cl[Ni]Cl.O.O.O.O.O.O.[BH4-].[Na+]>>CCCCCc1cc(NCc2ccccc2)c(N)c(N(Cc2ccc(OC)cc2)Cc2ccc(OC)cc2)n1",
        "output": "269"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.CO.Cc1cc(C)c(CNC(=O)c2cc(Br)nc3c2cnn3C(C)C)c(=O)[nH]1.Cl.ClCCl.O.O=C([O-])[O-].O=C1CCNCC1.[K+].[K+]>>Cc1cc(C)c(CNC(=O)c2cc(N3CCC(=O)CC3)nc3c2cnn3C(C)C)c(=O)[nH]1",
        "output": "647"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.Cn1ncnc1-c1ccccc1C(=O)N1CC2CN(C(=O)OC(C)(C)C)CC2C1.O=C(O)C(F)(F)F>>Cn1ncnc1-c1ccccc1C(=O)N1CC2CNCC2C1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)c1ccncc1.ClCCCl.O=C(Cl)c1ccccc1.OCCCBr.c1ccncc1>>O=C(OCCCBr)c1ccccc1",
        "output": "51"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)O.Clc1ccc(C(c2ccc(Cl)cc2)c2ccc3ncnc(Cl)c3c2)cc1.NC1CCN(c2ccccc2)CC1>>Clc1ccc(C(c2ccc(Cl)cc2)c2ccc3ncnc(NC4CCN(c5ccccc5)CC4)c3c2)cc1",
        "output": "110"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN1CCN(C(=O)Cc2ccc(N)cc2C(F)(F)F)CC1.Cl.O>>CCN1CCN(CCc2ccc(N)cc2C(F)(F)F)CC1",
        "output": "112"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1ccc(CNc2ccc3c(N)cccc3n2)o1.O.O=S(=O)(Cl)c1ccccc1>>Cc1ccc(CNc2ccc3c(NS(=O)(=O)c4ccccc4)cccc3n2)o1",
        "output": "68"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1ccccc1.Nc1nccc2ccccc12.O=C(O)C1CCN(c2ccccc2)CC1>>O=C(Nc1nccc2ccccc12)C1CCN(c2ccccc2)CC1",
        "output": "368"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.ClCCl.Cn1cc(Nc2cnc3c(n2)c(C(=O)NC(C)(C)CO)cn3COCC[Si](C)(C)C)cn1.O=C(O)C(F)(F)F.[NH4+].[OH-]>>Cn1cc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)CO)c3n2)cn1",
        "output": "981"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.O=C(Cl)OCc1ccccc1.O=C([O-])O.OCC1CCCN1.[Na+]>>O=C(OCc1ccccc1)N1CCCC1CO",
        "output": "427"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)COC(CCCO)OC1.CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC1(C)COC(CCC=O)OC1",
        "output": "142"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "OC(CCl)CN1CCN(C(c2ccccc2)c2ccccc2)CC1.Sc1cccc2ncccc12>>OC(CSc1cccc2ncccc12)CN1CCN(C(c2ccccc2)c2ccccc2)CC1",
        "output": "460"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)NCCN.CN(C)C=O.O=C=Nc1ccc(-c2c[nH]c(=O)cn2)cc1>>CC(=O)NCCNC(=O)Nc1ccc(-c2c[nH]c(=O)cn2)cc1",
        "output": "35"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CN(C)CC(c1ccccc1)n1cc([N+](=O)[O-])cn1.O=[N+]([O-])c1cc[nH]n1.O=[N+]([O-])c1cn[nH]c1.[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN(C)CC(c1ccccc1)n1cc(N)cn1",
        "output": "628"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)c1ccc(Cl)c(N(C)C(=O)c2cc3c(s2)-c2ccc(Br)cc2OCC3)c1.Cl.O.O.[Li]O>>CN(C(=O)c1cc2c(s1)-c1ccc(Br)cc1OCC2)c1cc(C(=O)O)ccc1Cl",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)Cc1cc(C(=O)O)ccc1OCc1ccc(F)cc1.CCN(CC)CC.ClC(Cl)Cl.NCCc1ccncc1.O=P(Cl)(c1ccccc1)c1ccccc1>>CC(C)Cc1cc(C(=O)NCCc2ccncc2)ccc1OCc1ccc(F)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.Cl[Sn](Cl)(Cl)Cl.O.O.O=C(CCN1CCc2ccc([N+](=O)[O-])cc2C1)OCc1ccccc1.O=C([O-])O.[Na+]>>Nc1ccc2c(c1)CN(CCC(=O)OCc1ccccc1)CC2",
        "output": "71"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)c1nc(-c2cccc(NC(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Cl)n2)s1.Nc1ccc(OCCN2CCCC2)c(Cl)c1>>CN(C)c1nc(-c2cccc(NC(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Nc3ccc(OCCN4CCCC4)c(Cl)c3)n2)s1",
        "output": "907"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl.O=C(O)CN1CCC(c2ccc(F)cc2)(c2ccc(F)cc2)C1=O.c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>O=C(CN1CCC(c2ccc(F)cc2)(c2ccc(F)cc2)C1=O)N1CCN(C(c2ccccc2)c2ccccc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCOC(C)=O.Nc1ccc(Cl)cc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=[N+]([O-])c1cccc2c(Br)cccc12.[Pd].[Pd]>>O=[N+]([O-])c1cccc2c(Nc3ccc(Cl)cc3)cccc12",
        "output": "405"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#Cc1ccc(C=O)cc1.CC(=O)O.CN1CCNCC1.CO.Cl.[BH3-]C#N.[Na+].[Na+].[OH-]>>C#Cc1ccc(CN2CCN(C)CC2)cc1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1cn([C@H]2C[C@H](O)[C@@H](CN)O2)c(=O)[nH]c1=O.O=C(Cl)c1ccccc1.[Na+].[OH-]>>CCc1cn([C@H]2C[C@H](O)[C@@H](CNC(=O)c3ccccc3)O2)c(=O)[nH]c1=O",
        "output": "271"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCCCCBr.CCCC[N+](CCCC)(CCCC)CCCC.CN(C(=O)Oc1ccc(F)c(F)c1)[C@@H]1CC[C@@H](O)CC1.O=S(=O)([O-])O.[Na+].[OH-]>>CN(C(=O)Oc1ccc(F)c(F)c1)[C@@H]1CC[C@@H](OCCCCBr)CC1",
        "output": "95"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNC.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2cc(Br)ccc2n1>>CN(C)C(=O)c1ccc2cc(Br)ccc2n1",
        "output": "605"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(Cc1cc(Br)ccc1O)c1ccc(C(=O)OC)cn1.CO.[Na+].[OH-]>>CCN(Cc1cc(Br)ccc1O)c1ccc(C(=O)O)cn1",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CS(=O)(=O)c1nccc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(Cl)c2)n1.NCCCO>>O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(NCCCO)n2)cc1Cl",
        "output": "629"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CS(=O)(=O)N1CCNCC1.F[P-](F)(F)(F)(F)F.O=C(O)Cn1nc(-c2ccccc2)c2c(Cl)c(-c3ccccc3)nnc21>>CS(=O)(=O)N1CCN(C(=O)Cn2nc(-c3ccccc3)c3c(Cl)c(-c4ccccc4)nnc32)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCCCCN2C(=O)c3ccccc3C2=O)C1c1ccccc1[N+](=O)[O-].NN.O>>COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCCCCN)C1c1ccccc1[N+](=O)[O-]",
        "output": "242"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CC(C)(C)C(=O)N2C.NN1CCN(C2CCCC2)CC1>>COc1cc(C(=O)NN2CCN(C3CCCC3)CC2)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CC(C)(C)C(=O)N2C",
        "output": "55"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.N#CC1CCNCC1.O=C(NC1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)Oc2ccc([N+](=O)[O-])cc2)C1)c1ccccc1.O=C([O-])[O-].[K+].[K+]>>N#CC1CCN(C(=O)N2CC(NC(=O)c3ccccc3)CC(c3ccc(C(F)(F)F)cc3)C2)CC1",
        "output": "770"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(N)C(F)(F)F.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)c1ccncc1.Cn1nc(-c2cnc3[nH]cc(C(=O)O)c3n2)c2ccc(Cl)cc21.F[P-](F)(F)(F)(F)F>>Cn1nc(-c2cnc3[nH]cc(C(=O)NC(C)(C)C(F)(F)F)c3n2)c2ccc(Cl)cc21",
        "output": "737"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.CS(=O)(=O)c1ccc(OCC[C@@H]2C[C@@H]2C2CCN(C(=O)OCc3ccccc3)CC2)nc1.[Pd]>>CS(=O)(=O)c1ccc(OCC[C@@H]2C[C@@H]2C2CCNCC2)nc1",
        "output": "428"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.ClCCl.OCc1ccc2cc[nH]c2c1.[H-].[Na+]>>CC(C)(C)[Si](C)(C)OCc1ccc2cc[nH]c2c1",
        "output": "193"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C(=O)Cl.COc1cccc2c1CC(N)CC2>>COc1cccc2c1CC(NC(=O)C(C)C)CC2",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)N.CCOC(=O)[C@@H]1C[C@H]1c1ccnc(Cl)c1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2]>>CCOC(=O)[C@@H]1C[C@H]1c1ccnc(NC(C)C)c1",
        "output": "70"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC1(c2cccc(NS(C)(=O)=O)c2)C2CNCC21.N#Cc1ccc(C=O)cc1.O=C(O)C(F)(F)F>>CCC1(c2cccc(NS(C)(=O)=O)c2)C2CN(Cc3ccc(C#N)cc3)CC21",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(=Cc2cccc(Oc3ccc(Br)cn3)c2)CC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>CC(C)(C)OC(=O)N1CCC(=Cc2cccc(Oc3ccc(B4OC(C)(C)C(C)(C)O4)cn3)c2)CC1",
        "output": "943"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.Cl.Clc1ccc(-c2ccccc2CN2CCC3(CC2)OCCO3)cc1.O>>O=C1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1",
        "output": "251"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)c1cc(Br)cc(C(C)C)c1N.CC(C)c1cc(Oc2ccccc2)cc(C(C)C)c1NC(N)=S.Cc1ccccc1.O=C([O-])[O-].O=C([O-])[O-].Oc1ccccc1.[Cu+2].[K+].[K+].[K+].[OH-]>>CC(C)c1cc(Oc2ccccc2)cc(C(C)C)c1N",
        "output": "238"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCO.C[Si](C)(C)Cl.Cc1ccc(S(=O)(=O)n2ccc3c(Nc4ccc5cn[nH]c5c4)nc(Cl)nc32)cc1.Nc1ccc(S(N)(=O)=O)cc1>>Cc1ccc(S(=O)(=O)n2ccc3c(Nc4ccc5cn[nH]c5c4)nc(Nc4ccc(S(N)(=O)=O)cc4)nc32)cc1",
        "output": "592"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)CO1.CCN(C(C)C)C(C)C.CN(C)C=O.CO.Cl.Cl.ClCCl.Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)NC3CCNC3)ccc21>>Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)NC3CCN(CC(C)(C)O)C3)ccc21",
        "output": "76"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCCCC1.CCOC(C)=O.Clc1cncc(Cl)n1.Oc1ccnc2ccccc12>>Clc1cncc(Oc2ccnc3ccccc23)n1",
        "output": "210"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCCCC1CC(=O)O.COc1cccc(C(=O)CBr)c1>>COc1cccc(C(=O)COC(=O)CC2CCCCN2C(=O)OC(C)(C)C)c1",
        "output": "523"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCO.CN.O=S(=O)(c1ccccc1)c1cc(Br)nc(Br)c1>>CNc1cc(S(=O)(=O)c2ccccc2)cc(Br)n1",
        "output": "715"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.N.O.O=C(O)CCc1c(C=C2C(=O)Nc3ccccc32)[nH]c2c1CCCC2.O=C(n1ccnc1)n1ccnc1>>NC(=O)CCc1c(C=C2C(=O)Nc3ccccc32)[nH]c2c1CCCC2",
        "output": "313"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1C(=O)OCCc2cc([N+](=O)[O-])ccc21.CO.[Pd]>>CN1C(=O)OCCc2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCCCC1.COc1c(C)c(C(=O)c2ccccc2F)c(OC)c2ccccc12.ClCCl>>COc1c(C)c(C(=O)c2ccccc2F)c(O)c2ccccc12",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)c1cc(N)n(C)n1.ClCCl.O=C(Cl)Oc1ccccc1.O=C([O-])O.[Na+]>>CC(C)c1cc(NC(=O)Oc2ccccc2)n(C)n1",
        "output": "700"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(Br)c2)n1.NS(=O)(=O)c1cccc(B(O)O)c1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(S(N)(=O)=O)c3)c2)n1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)[N-]C(C)C.CN(C)C=O.Fc1cc(Br)cc(F)c1N=NN1CCCC1.O>>O=Cc1c(Br)cc(F)c(N=NN2CCCC2)c1F",
        "output": "239"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O=S(=O)(Nc1nccnc1-c1ccc(CCl)cc1)c1ccccc1C(F)(F)F.c1ccc(-c2cc3ccccc3[nH]2)nc1>>O=S(=O)(Nc1nccnc1-c1ccc(Cn2c(-c3ccccn3)cc3ccccc32)cc1)c1ccccc1C(F)(F)F",
        "output": "556"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)c1nc2c(C(F)(F)F)cc(-c3ccco3)cn2c1Cl.c1ccc(CN2CCNCC2)cc1>>O=C(c1nc2c(C(F)(F)F)cc(-c3ccco3)cn2c1Cl)N1CCN(Cc2ccccc2)CC1",
        "output": "729"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "NC1CCN(c2ccc(NC(=O)c3oc(N4CCCCC4)nc3C(F)(F)F)cn2)CC1.O=C(O)c1c(F)cccc1F>>O=C(Nc1ccc(N2CCC(NC(=O)c3c(F)cccc3F)CC2)nc1)c1oc(N2CCCCC2)nc1C(F)(F)F",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1ccc2nc(-c3cnn(-c4ccccc4)c3)c(N(C)C(C)C)nc2c1.ClC(Cl)Cl.[Na+].[OH-]>>CC(C)N(C)c1nc2cc(C(=O)O)ccc2nc1-c1cnn(-c2ccccc2)c1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.CC(C)(C)[Si](C)(C)CC1CN2CCNCC2CN1.CCN(CC)CC.ClCCl>>CC(=O)N1CCN2CC(C[Si](C)(C)C(C)(C)C)NCC2C1",
        "output": "125"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CNc1ccccc1.ClCCl.O=C([O-])[O-].O=Cc1ccccc1S(=O)(=O)Cl.O=S([O-])O.[Na+].[Na+].[Na+]>>CN(c1ccccc1)S(=O)(=O)c1ccccc1C=O",
        "output": "791"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1C[C@@H]2CN3CCCc4cccc(c43)[C@@H]2C1.CCOC(C)=O.CN(C)C=O.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1C[C@@H]2CN3CCCc4cc(Br)cc(c43)[C@@H]2C1",
        "output": "4"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(C2(C(F)(F)C(F)(F)C(F)(F)F)CC(c3ccc(Cl)cc3)=NO2)ccc1NC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>Cc1cc(C2(C(F)(F)C(F)(F)C(F)(F)F)CC(c3ccc(Cl)cc3)=NO2)ccc1N",
        "output": "782"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.O=C(c1ccc(F)cc1)C1CCNCC1.O=S(=O)(Cl)c1ccccc1.c1ccncc1>>O=C(c1ccc(F)cc1)C1CCN(S(=O)(=O)c2ccccc2)CC1",
        "output": "99"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(C)=O.COC(=O)c1cc2c(cc1O)-c1[nH]c3c(F)c(C(F)(F)F)c(Br)cc3c1CC2.O.[Li+].[OH-]>>O=C(O)c1cc2c(cc1O)-c1[nH]c3c(F)c(C(F)(F)F)c(Br)cc3c1CC2",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)Cc1ccc(Nc2nc3cc(F)ccc3s2)c(Cl)c1.[Na+].[OH-]>>O=C(O)Cc1ccc(Nc2nc3cc(F)ccc3s2)c(Cl)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CC(=O)O.Nc1ccc(-c2ccc(O[C@H]3CN4CCC3CC4)nn2)cc1.O=C1CCC(=O)N1Br>>Nc1ccc(-c2ccc(O[C@H]3CN4CCC3CC4)nn2)cc1Br",
        "output": "4"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.O=C1CCC(=O)N1Cl.Oc1ccc2cc(-c3cc(F)c(O)c(F)c3)ccc2c1>>Oc1ccc2cc(-c3cc(F)c(O)c(F)c3)ccc2c1Cl",
        "output": "121"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1c(C2(c3cc(Br)c(O)c(Br)c3C)OS(=O)(=O)c3ccccc32)cc(Br)c(O)c1Br.Cl.NCCCN.O>>CC(C)(C)OC(=O)NCCCN",
        "output": "631"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)[C@@H]1O[C@@H]1c1ccc(F)cc1.O.[Li+].[OH-]>>O=C(O)[C@@H]1O[C@@H]1c1ccc(F)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccccc1.O=C1CCC(=O)O1.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(C(=O)CCC(=O)O)cc1",
        "output": "345"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1nnc(-c2cc(O)cc(Br)c2)o1.[K+]>>Cc1nnc(-c2cc(O)cc(B3OC(C)(C)C(C)(C)O3)c2)o1",
        "output": "942"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1ccc(OCCN2CCCC2)cc1.C1COCCO1.CC(=O)N(C)C.CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CSc1cccc2nc(N)nn12.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CSc1cccc2nc(Nc3ccc(OCCN4CCCC4)cc3)nn12",
        "output": "970"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccccc1.CC(C)(C)OC(=O)N1C[C@@H](CCl)c2c1cc(O)c1ccccc21.CCOC(C)=O.CN(C)C=O.[I-].[K+]>>CC(C)(C)OC(=O)N1C[C@@H](CCl)c2c1cc(OCc1ccccc1)c1ccccc21",
        "output": "127"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1CCCCC1C(=O)O.Cc1ccc(-c2ncco2)cc1-c1ccc(N)cc1.ClCCCl.ClCCl>>Cc1ccc(-c2ncco2)cc1-c1ccc(NC(=O)C2CCCCN2C)cc1",
        "output": "563"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CC[C@@H]1C(=O)N(C)c2cnc(Cl)nc2N1C(C)C.COc1cc(N2CCC(N3CCCC3)CC2)ccc1N.Cl>>CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(N4CCC(N5CCCC5)CC4)cc3OC)nc2N1C(C)C",
        "output": "808"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.Clc1nc(Cl)c2c(-c3ccccc3)cccc2n1.NCc1ccccn1>>Clc1nc(NCc2ccccn2)c2c(-c3ccccc3)cccc2n1",
        "output": "110"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(Cc1cccc(Nc2sc(-c3ccc(F)cc3)cc2C(N)=O)n1)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CNCc1cccc(Nc2sc(-c3ccc(F)cc3)cc2C(N)=O)n1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=S(Cl)Cl.OCc1cnc2cc(-c3ccccc3)ccc2c1>>ClCc1cnc2cc(-c3ccccc3)ccc2c1",
        "output": "477"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)c1cccc(S(=O)(=O)Cl)c1.Nc1ccc(C(=O)O)c(O)c1>>CC(=O)c1cccc(S(=O)(=O)Nc2ccc(C(=O)O)c(O)c2)c1",
        "output": "68"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NCC(CC1(C(F)(F)F)CC1)c1ccc(C(F)(F)F)nc1.O=C(O)c1ccccc1Cl>>O=C(NCC(CC1(C(F)(F)F)CC1)c1ccc(C(F)(F)F)nc1)c1ccccc1Cl",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.CO.ClC(Cl)Cl.O.O=c1ccnc(Nc2ccccc2)[nH]1>>O=c1[nH]c(Nc2ccccc2)ncc1Br",
        "output": "381"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.COC(=O)[C@H](CC(C)C)NC(=O)C[C@H](O)C[C@H](O)C=CC(=C(c1ccc(F)cc1)c1ccc(F)cc1)c1nnnn1C.O.[Na+].[OH-]>>CC(C)C[C@H](NC(=O)C[C@H](O)C[C@H](O)C=CC(=C(c1ccc(F)cc1)c1ccc(F)cc1)c1nnnn1C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.COC(=O)COc1ccccc1Oc1cc(NC(C)=O)c(F)cc1[N+](=O)[O-].O.[Fe]>>COC(=O)COc1ccccc1Oc1cc(NC(C)=O)c(F)cc1N",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O.O=C1OC(=Cc2ccc(Cl)c([N+](=O)[O-])c2)c2ccccc21.[Cl-].[Fe].[NH4+]>>Nc1cc(C=C2OC(=O)c3ccccc32)ccc1Cl",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=C([C@H]1CCCN1C(=O)OCc1ccccc1)N1CCCC1.[Pd]>>O=C([C@H]1CCCN1)N1CCCC1",
        "output": "568"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)C(C)(C)CC(=O)NCC(=O)c1ccc([N+](=O)[O-])cc1.COC(=O)C(C)(C)CCC(=O)O.Cl.NCC(=O)c1ccc([N+](=O)[O-])cc1>>COC(=O)C(C)(C)CCC(=O)NCC(=O)c1ccc([N+](=O)[O-])cc1",
        "output": "645"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.CC(C)=O.O=C(CCl)c1ccc(O)c(F)c1.O=C([O-])[O-].[K+].[K+]>>O=C(CCl)c1ccc(OCc2ccccc2)c(F)c1",
        "output": "127"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Nc1ccc2c(c1)OCCO2.Oc1cccc(Nc2nc(Cl)ncc2Br)c1.Oc1cccc(Nc2ncc(F)c(Nc3ccc4c(c3)OCCO4)n2)c1>>Oc1cccc(Nc2nc(Nc3ccc4c(c3)OCCO4)ncc2Br)c1",
        "output": "907"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.Cc1ccc(CCl)nc1.Cl.O=C([O-])[O-].O=[N+]([O-])c1ccc(O)cc1F.[I-].[K+].[K+].[K+]>>Cc1ccc(COc2ccc([N+](=O)[O-])c(F)c2)nc1",
        "output": "616"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=C(O)c1cccnc1Cl.O=S(=O)(O)O>>COC(=O)c1cccnc1Cl",
        "output": "521"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CSCCN1.COCCOC.COc1cc2c(Nc3ccc4cn[nH]c4c3)c(C#N)cnc2cc1OCCCl.[I-].[Na+]>>COc1cc2c(Nc3ccc4cn[nH]c4c3)c(C#N)cnc2cc1OCCN1CCSCC1",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.NN.O=C(O)C(F)(F)F.O=C1c2ccccc2C(=O)N1CCCN1CCCCCC1>>NCCCN1CCCCCC1",
        "output": "242"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)c1cc(Cl)cc2ccoc12.[K+].[OH-]>>O=C(O)c1cc(Cl)cc2ccoc12",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCc1ccc(C(=O)O)cc1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cl.F[B-](F)(F)F.NC(=O)NCc1ccc(CNC(=O)[C@H](N)CCCNC(N)=N[N+](=O)[O-])cc1>>CCCCc1ccc(C(=O)N[C@H](CCCNC(N)=N[N+](=O)[O-])C(=O)NCc2ccc(CNC(N)=O)cc2)cc1",
        "output": "718"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCCO.CCCc1nc2c(N)nc3cc(Br)ccc3c2n1CCCONC(=O)C(C)C.Cc1ccccc1.ClC(Cl)Cl.O.O=C([O-])[O-].OB(O)c1ccccc1.[Na+].[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCc1nc2c(N)nc3cc(-c4ccccc4)ccc3c2n1CCCONC(=O)C(C)C",
        "output": "909"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC1(c2ccc(C=O)cc2)CC1.CCC1(c2ccc(C=O)cc2)CCC1.[BH4-].[K+]>>CCC1(c2ccc(CO)cc2)CCC1",
        "output": "356"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.CN1CCC(N2CCNCC2)CC1.CO.ClC(Cl)Cl.O=C(n1ccnc1)n1ccnc1>>CN1CCC(N2CCN(C(=O)NCCCCN3CCN(c4cc(C(F)(F)F)nc(C(C)(C)C)n4)CC3)CC2)CC1",
        "output": "734"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCOCC.C[C@@H](Br)C(=O)Cl.C[N+](C)(C/C=C/C1=C(C(=O)[O-])N2C(=O)[C@@H](N)[C@H]2SC1)CC(N)=O.ClCCl.I.O>>C[C@@H](Br)C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(/C=C/C[N+](C)(C)CC(N)=O)CS[C@H]12",
        "output": "159"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CS(C)=O.N#Cc1ccc(-n2nc(C(F)(F)F)c3c(-c4nc5ccc(F)cc5[nH]4)cccc32)cc1N[C@@H]1CC[C@@H](O)CC1.OO.[Cl-].[Na+].[Na+].[OH-]>>NC(=O)c1ccc(-n2nc(C(F)(F)F)c3c(-c4nc5ccc(F)cc5[nH]4)cccc32)cc1N[C@@H]1CC[C@@H](O)CC1",
        "output": "180"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Nc1c(F)ccc(N)c1F.CC(C)S(=O)(=O)Cl.ClCCl.c1ccncc1>>CC(C)S(=O)(=O)Nc1ccc(F)c(NC(=O)OC(C)(C)C)c1F",
        "output": "194"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.COc1ccc(C(=O)CBr)cc1.Cl.Cl.ClC(Cl)Cl.c1ccc2c(CCCCN3CCNCC3)cccc2c1>>COc1ccc(C(=O)CN2CCN(CCCCc3cccc4ccccc34)CC2)cc1",
        "output": "413"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CI.CN(C)C=O.O.O=C1O[C@@H](Cn2ccnn2)CN1c1ccc(-c2ccc(C3=NO[C@H](CO)C3)nc2)c(F)c1.[H-].[Na+]>>COC[C@@H]1CC(c2ccc(-c3ccc(N4C[C@H](Cn5ccnn5)OC4=O)cc3F)cn2)=NO1",
        "output": "140"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "N#Cc1ccc2c(c1)C(=O)CC[C@H]2c1ccc(Cl)c(Cl)c1.O.O=S(=O)(O)O.[Na+].[OH-]>>NC(=O)c1ccc2c(c1)C(=O)CC[C@H]2c1ccc(Cl)c(Cl)c1",
        "output": "419"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)N1CC(C(=O)OC)Oc2ccc(C#N)cc21.Cl.[Na+].[OH-]>>CCOC(=O)N1CC(C(=O)O)Oc2ccc(C#N)cc21",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCC1CO1.O.Oc1ccc(OCCCC2CC2)cc1.[K+].[OH-]>>c1cc(OCC2CO2)ccc1OCCCC1CC1",
        "output": "18"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CCN(CC)CC.CCOC(C)=O.Cc1cccc(C[C@@H](O)C(=O)O)c1>>Cc1cccc(C[C@@H](O)C(=O)OCc2ccccc2)c1",
        "output": "403"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC1=N[C@](CF)(c2cc(N)ccc2F)COC1(CF)CF.CCOC(C)=O.CN(C)C=O.Cc1cc(C#N)cnc1C(=O)O.ClCCCl.O.On1nnc2cccnc21>>Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(CF)COC(CF)(CF)C(NC(=O)OC(C)(C)C)=N2)c1",
        "output": "985"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1cc(NCCCCCC(=O)N(C)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)sc1C(=O)N(C)CCN(C)C(=O)OC(C)(C)C.Cc1ccccc1.Cl>>CNCCN(C)C(=O)c1sc(NCCCCCC(=O)N(C)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)cc1C",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC(=O)Cl.CCN(CC)CC.ClC(Cl)Cl.ClCCl.NCc1ccc(C2=NOC(c3cc(Br)c(F)c(Br)c3)(C(F)(F)F)C2)cc1Cl>>CCCC(=O)NCc1ccc(C2=NOC(c3cc(Br)c(F)c(Br)c3)(C(F)(F)F)C2)cc1Cl",
        "output": "206"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NCCC[C@@H]1CN(c2ccc3c(c2)NC(=O)CS3)C(=O)O1.Nc1cccc(F)c1C(=O)O>>Nc1cccc(F)c1C(=O)NCCC[C@@H]1CN(c2ccc3c(c2)NC(=O)CS3)C(=O)O1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CCCCP(C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2.COC(=O)[C@@H](O)Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.Cc1cc(N)cc(Br)c1.O.[F-].[K+].[Pd+2]>>COC(=O)[C@@H](O)Cn1cc(-c2cc(C)cc(N)c2)cn1",
        "output": "971"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=O.CC#N.CC(=O)O.CC(OCC1(c2ccccc2)CCNCC1)c1cc(Cl)cc2cn[nH]c12.[BH3-]C#N.[Na+]>>CC(OCC1(c2ccccc2)CCN(C)CC1)c1cc(Cl)cc2cn[nH]c12",
        "output": "217"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1ncc2sc(-c3ccccc3)nc2c1O.CO.C[O-].NCC(=O)O.[Na+]>>O=C(O)CNC(=O)c1ncc2sc(-c3ccccc3)nc2c1O",
        "output": "977"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(COc1ccc2c(O)cc(-c3csc(C(C)C)n3)nc2c1Cl)OC.O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+].c1ccncc1>>COC(COc1ccc2c(Cl)cc(-c3csc(C(C)C)n3)nc2c1Cl)OC",
        "output": "177"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1ccc(C(=O)Nc2ccccc2N)cc1.O=C(O)c1ccc([N+](=O)[O-])cc1>>CC(C)(C)c1ccc(C(=O)Nc2ccccc2NC(=O)c2ccc([N+](=O)[O-])cc2)cc1",
        "output": "50"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCC/C=C/C=C/C(=O)OCC.CO.Cl.[Na+].[OH-]>>CCCCCCC/C=C/C=C/C(=O)O",
        "output": "122"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC(=O)O)C(=O)c1ccc2c(c1)c1c(n2C)CCC(C2CCOCC2)C1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCC(F)F>>CCN(CC(=O)NCC(F)F)C(=O)c1ccc2c(c1)c1c(n2C)CCC(C2CCOCC2)C1",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)CCC(=O)c1c[nH]c2ccc(Cl)cc12.C[Si](C)(C)CCO.ClCCl.[Br-].[Li+]>>C[Si](C)(C)CCOC(=O)CCC(=O)c1c[nH]c2ccc(Cl)cc12",
        "output": "289"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCC.N#CCCc1ccccn1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCCCc1ccccn1",
        "output": "246"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Fc1cccc(F)c1-c1ccc2[nH]ncc2c1.II.O.[K+].[OH-]>>Fc1cccc(F)c1-c1ccc2[nH]nc(I)c2c1",
        "output": "923"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.Cc1cc(CCO)ccn1.O=C1NC(=O)c2ccccc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(CCN2C(=O)c3ccccc3C2=O)ccn1",
        "output": "420"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2ccc3c(c2)CCNCC3)CC1.CCN(C(C)C)C(C)C.CN(C)C=O.O=C(O)C1CC1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc3c(c2)CCN(C(=O)C2CC2)CC3)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)s2)n1Cc1ccc(C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)s2)n1Cc1ccc(C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCCc1ccccc1.CN(C)C=O.COC(=O)c1n[nH]cc1[N+](=O)[O-].O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)c1nn(CCc2ccccc2)cc1[N+](=O)[O-]",
        "output": "577"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)[Mg]Cl.CN(C)C=O.Cc1cc(Br)c(C)cc1Br.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li]CCCC>>Cc1cc(C=O)c(C)cc1Br",
        "output": "638"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Brc1cncc(Br)c1.CC(C)(C)OC(=O)N1C[C@@H]2CCN[C@@H]2C1>>CC(C)(C)OC(=O)N1C[C@@H]2CCN(c3cncc(Br)c3)[C@@H]2C1",
        "output": "597"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.COC(=O)C1(C#N)CC[NH2+]CC1.ClCCl.Cn1nc(C(F)F)cc1NC(=O)Oc1ccccc1.O.[Cl-]>>COC(=O)C1(C#N)CCN(C(=O)Nc2cc(C(F)F)nn2C)CC1",
        "output": "525"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)O.c1ccc(CN2CCC(C3CO3)CC2)cc1.c1ccc2c(C3CCNCC3)c[nH]c2c1>>OC(CN1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(Cc2ccccc2)CC1",
        "output": "76"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Cl.CSc1nccc(-c2cc(N)c(Cl)nc2-c2ccc(F)cc2)n1.ClCCl.O=C([O-])O.[Na+].c1ccncc1>>CSc1nccc(-c2cc(NC(C)=O)c(Cl)nc2-c2ccc(F)cc2)n1",
        "output": "422"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)[C@H](C)O[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)C(=O)OCc1ccccc1.CCOC(C)=O.[Pd]>>CCOC(=O)[C@H](C)O[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.O=[N+]([O-])c1cc(-c2ccccc2)c(Cl)c([N+](=O)[O-])c1.[H][H].[Ni]>>Nc1cc(N)c(Cl)c(-c2ccccc2)c1",
        "output": "204"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)c1cc(Cc2ccc3c(c2)OCO3)on1.O.[Na+].[OH-]>>O=C(O)c1cc(Cc2ccc3c(c2)OCO3)on1",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)CN(Cc1cccc(COc2ccc(-c3ccc(F)cc3F)cc2)c1)C(=O)c1nccn1C.[Li+].[OH-]>>Cn1ccnc1C(=O)N(CC(=O)O)Cc1cccc(COc2ccc(-c3ccc(F)cc3F)cc2)c1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccccc1.CC(C)(C)OC(=O)N1CC[C@@H](O)[C@H]1C(=O)O.CO.O.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)(C)OC(=O)N1CC[C@@H](O)[C@H]1C(=O)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1c(C)c(N2CCNCC2)c(C)c2c1OC(C)(C)C2.FC(F)(F)Oc1ccc(Br)cc1>>Cc1c(C)c(N2CCN(c3ccc(OC(F)(F)F)cc3)CC2)c(C)c2c1OC(C)(C)C2",
        "output": "294"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CS(=O)(=O)Cl.Cl.O.O=C([O-])[O-].O=C1CCNCC1.[K+].[K+]>>CS(=O)(=O)N1CCC(=O)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1cccc(-c2ccc(OC)c(C3C4=C(CC(C)(C)CC4=O)OC4=C3C(=O)CC(C)(C)C4)c2C)n1.O.O.[Li+].[OH-]>>COc1ccc(-c2cccc(C(=O)O)n2)c(C)c1C1C2=C(CC(C)(C)CC2=O)OC2=C1C(=O)CC(C)(C)C2",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1ncc(Br)cn1.O.O=C([O-])C(F)(F)F.O=C([O-])C(F)(F)F.O=C([O-])[O-].OB(O)c1ccc(Cl)cc1F.[Na+].[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Nc1ncc(-c2ccc(Cl)cc2F)cn1",
        "output": "871"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2nc(-c3cccc(C(F)(F)F)c3)cs2)CC1.CCOC(C)=O.Cl>>FC(F)(F)c1cccc(-c2csc(N3CCNCC3)n2)c1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-c2nc(C3CCC(NC(=O)OC(C)(C)C)CC3)cnc2N)cc1F.[Li+].[OH-]>>CC(C)(C)OC(=O)NC1CCC(c2cnc(N)c(-c3ccc(C(=O)O)c(F)c3)n2)CC1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1C(F)(F)F.Cc1noc(-c2cccc(C(=O)CC(=O)OC(C)(C)C)c2)c1COC1CCCCO1>>Cc1noc(-c2cccc(C(=O)CC(=O)Nc3cc(C(F)(F)F)c(N(C)C)cc3NC(=O)OC(C)(C)C)c2)c1COC1CCCCO1",
        "output": "929"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(C(F)F)c(Oc2cc(Cl)cc(C#N)c2)c1F.ClCCl.O=C(O)C(F)(F)F>>N#Cc1cc(Cl)cc(Oc2c(C(F)F)ccc(CN)c2F)c1",
        "output": "793"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCOCCOCCN1.O=C(Cl)C12CC3CC(CC(C3)C1)C2>>O=C(N1CCOCCOCCOCC1)C12CC3CC(CC(C3)C1)C2",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Nc1cccc(I)c1.O=C([O-])Cc1nc(N2CCOCC2)cc(=O)[nH]1.[Na+]>>O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)Nc1cccc(I)c1",
        "output": "891"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCC(N)CC1.COc1ccc(C)c2c1C(Nc1ccc3cc(N)ccc3n1)CC2.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1ccc(C)c2c1C(Nc1ccc3cc(NC(=O)NC4CCN(C)CC4)ccc3n1)CC2",
        "output": "914"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(c1ccccc1-c1ccccc1)C(C)(C)C.COc1ccc(Cl)cc1.OB(O)c1ccccc1.[F-].[K+].[Pd+2]>>COc1ccc(-c2ccccc2)cc1",
        "output": "892"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(Cc1nc2ccccc2n1Cc1cccnc1)C1CCCc2cccnc21.N#CCCCBr.c1ccc(CCN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)cc1>>N#CCCCn1c(CN(CCc2ccccc2)C2CCCc3cccnc32)nc2ccccc21",
        "output": "495"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CC(C)c1cccc(Nc2ncc(C(F)(F)F)c(Cl)n2)c1.NC1CCCC1.O.O=C([O-])[O-].[K+].[K+]>>CC(C)c1cccc(Nc2ncc(C(F)(F)F)c(NC3CCCC3)n2)c1",
        "output": "166"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CCS(=O)(=O)Cl.NCc1cccc(-c2nc(=O)c3ccccc3s2)n1.O.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CCS(=O)(=O)NCc1cccc(-c2nc(=O)c3ccccc3s2)n1",
        "output": "493"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)C[C@H]1C[C@@H](CO)C1(C)C.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)C[C@H]1C[C@@H](COS(C)(=O)=O)C1(C)C",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C1Cc2cscc2C1.O.[K+].[OH-]>>O=C(O)C1Cc2cscc2C1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.FC(F)(F)C1CCCN1.O=C(Cl)CCl>>O=C(CCl)N1CCCC1C(F)(F)F",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)CCN1CC(COc2ccccc2)OC1=O.CO.[BH4-].[Li+]>>O=C1OC(COc2ccccc2)CN1CCCO",
        "output": "225"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.O.O=C(O)CCc1c[nH]c2ccccc12.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OCCCc1c[nH]c2ccccc12",
        "output": "231"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.ClCCl.NCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1>>CS(=O)(=O)NCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1",
        "output": "742"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CNCCN1.COc1cc(NC(=O)CCCCCBr)c2nccc(C)c2c1.O>>COc1cc(NC(=O)CCCCCN2CCNCC2)c2nccc(C)c2c1",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCOC(=O)CBr.O=C([O-])[O-].O=[N+]([O-])c1ccc(O)cc1[N+](=O)[O-].[Cs+].[Cs+]>>CCOC(=O)COc1ccc([N+](=O)[O-])c([N+](=O)[O-])c1",
        "output": "123"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1ccc(/C=C/c2cnc(-c3ccc(N(C)C)cc3)s2)cc1.ClCCl.O=C([O-])O.[Na+]>>CN(C)c1ccc(-c2ncc(/C=C/c3ccc(O)cc3)s2)cc1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CNc1nc(N)nc(Cl)n1.OCC(F)(F)F.[K+].[OH-]>>CNc1nc(N)nc(OCC(F)(F)F)n1",
        "output": "213"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CSCCN.O.O=C([O-])[O-].O=[N+]([O-])c1cc(-c2nc3ccccc3o2)ccc1F.[K+].[K+]>>CSCCNc1ccc(-c2nc3ccccc3o2)cc1[N+](=O)[O-]",
        "output": "572"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(Cl)nc32)CC1.CCOC(C)=O.COc1cccc2[nH]c(C(F)F)nc12.CS(C)=O.ClCCl.O.O=C([O-])[O-].[K+].[K+]>>COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)c2cnn(C3CCN(C(=O)OC(C)(C)C)CC3)c2n1",
        "output": "916"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc(I)cc(OC)c1OC.ClCCl.O.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1cc(I)cc(OC)c1O",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCc1cc(C(OCOC)(C(F)(F)F)C(F)(F)F)cc(CCC)c1Oc1ccc(I)c(C=O)c1.CO.O.[BH4-].[Na+]>>CCCc1cc(C(OCOC)(C(F)(F)F)C(F)(F)F)cc(CCC)c1Oc1ccc(I)c(CO)c1",
        "output": "356"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN1CCNCC1.Cc1c(C=O)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12.ClC(Cl)Cl.ClCCl.[Na+]>>Cc1c(CN2CCN(C)CC2)cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12",
        "output": "757"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=C(O)CCC(=O)N1CCCc2cc(O)ccc21.O=S(Cl)Cl>>COC(=O)CCC(=O)N1CCCc2cc(O)ccc21",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)OCC(CCn1cnc2cnc(N)nc21)COC(C)=O.CO.O=C([O-])[O-].[K+].[K+]>>CC(=O)OCC(CO)CCn1cnc2cnc(N)nc21",
        "output": "225"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(C)N1CCn2c(Cc3ccc(Cl)cc3-c3cccnc3)nc(=O)c(OCc3ccccc3)c2C1=O.O=S(=O)(O)O>>CC(C)N1CCn2c(Cc3ccc(Cl)cc3-c3cccnc3)nc(=O)c(O)c2C1=O",
        "output": "492"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrB(Br)Br.COc1ccc2c(c1)ncn2-c1ccc2cccc(N3CCC(N)CC3)c2n1.ClCCl.O=C([O-])[O-].[Na+].[Na+]>>NC1CCN(c2cccc3ccc(-n4cnc5cc(O)ccc54)nc23)CC1",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(C[C@@H]2NCCc3cc(OC)c(OC)cc32)cc1OC.N[C@H]1c2ccccc2C[C@H]1O.O=C(Br)CBr>>COc1ccc(C[C@H]2c3cc(OC)c(OC)cc3CCN2CC(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1OC",
        "output": "946"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.COC(=O)[C@@H](N)Cc1cccs1.C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O>>COC(=O)[C@H](Cc1cccs1)NC(=O)[C@H](C)NC(=O)Cc1cc(F)cc(F)c1",
        "output": "129"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCC.Cc1ccc(S(=O)(=O)O)cc1.NC1(C(=O)O)CCCCC1.O.OCc1ccccc1.c1ccccc1>>NC1(C(=O)OCc2ccccc2)CCCCC1",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.NC(=O)COc1cc2c(c(Cl)c1Cl)C1=CC(=O)CCC1(CCOC(=O)C(F)(F)F)C2.c1ccncc1>>N#CCOc1cc2c(c(Cl)c1Cl)C1=CC(=O)CCC1(CCOC(=O)C(F)(F)F)C2",
        "output": "172"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.CN(C)C=O.CN[C@H](CN1CC[C@H](O)C1)c1ccccc1.O=C(O)Cc1ccc2ncc(=O)[nH]c2c1.On1nnc2ccccc21>>CN(C(=O)Cc1ccc2ncc(=O)[nH]c2c1)[C@H](CN1CC[C@H](O)C1)c1ccccc1",
        "output": "633"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Clc1ncccn1.NCCO.O>>OCCNc1ncccn1",
        "output": "544"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CN(C)[C@H]1CCN(c2cc(N)c(C#N)cc2-c2ccccc2)C1.ClC(Cl)Cl.O=C1CCC(=O)N1I.[Na+].[OH-]>>CN(C)[C@H]1CCN(c2c(-c3ccccc3)cc(C#N)c(N)c2I)C1",
        "output": "834"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)O[Na].CN.CN.CN1Cc2cnc(S(C)(=O)=O)nc2N(c2cccc(NC(=O)OC(C)(C)C)c2)C1=O.Cl.ClCCl>>CNc1ncc2c(n1)N(c1cccc(NC(=O)OC(C)(C)C)c1)C(=O)N(C)C2",
        "output": "629"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.Cc1nc(-c2cn3c(n2)-c2ccc(C#N)cc2OCC3)n(-c2ccc(F)cc2F)n1.[AlH4-].[Li+]>>Cc1nc(-c2cn3c(n2)-c2ccc(CN)cc2OCC3)n(-c2ccc(F)cc2F)n1",
        "output": "175"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1=COCCC1.CCOC(C)=O.Cl.ClCCl.Oc1ccc(C(F)(F)F)cc1>>FC(F)(F)c1ccc(OC2CCCCO2)cc1",
        "output": "319"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.C[Si](C)(C)CCOCOc1cc(Br)cc2c(=O)n(COCC[Si](C)(C)C)cnc12.Cc1cccc(C)c1.[Na+].[Pd+2]>>C[Si](C)(C)CCOCOc1cc(N2CCOCC2)cc2c(=O)n(COCC[Si](C)(C)C)cnc12",
        "output": "294"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Cc1ncc(CO)c(CNc2ccc(C#N)cc2)c1O.N#Cc1ccc(CBr)cc1.O=C([O-])[O-].[K+].[K+]>>Cc1ncc(CO)c(CNc2ccc(C#N)cc2)c1OCc1ccc(C#N)cc1",
        "output": "623"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN.CN(C)C=O.Cl.Cl.O.O=C(O)Cn1c(=O)n(C2CCN([C@@H]3Cc4cccc5cccc3c45)CC2)c2ccccc21.On1nnc2ccccc21>>CNC(=O)Cn1c(=O)n(C2CCN([C@@H]3Cc4cccc5cccc3c45)CC2)c2ccccc21",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCOc1cccc(N)c1S(N)(=O)=O.CC(C)O.COc1ccc(Nc2nccc(Cl)n2)cc1OC.Cl>>C=CCOc1cccc(Nc2ccnc(Nc3ccc(OC)c(OC)c3)n2)c1S(N)(=O)=O",
        "output": "161"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C1CCOC1.CCN=C=NCCCN(C)C.CN(C)C=O.CN1C(C)(C)CC(N)CC1(C)C.COc1cc(C(=O)O)ccc1-c1nc2cc(Cl)c(Cl)cc2[nH]1.Cl>>COc1cc(C(=O)NC2CC(C)(C)N(C)C(C)(C)C2)ccc1-c1nc2cc(Cl)c(Cl)cc2[nH]1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.Cl.O.O=C(O)c1ccccc1Oc1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1ccccc1Oc1ccccc1",
        "output": "72"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1onc(C(C)C)c1C(=O)OC.O.[Na+].[OH-]>>COC(=O)c1c(C(C)C)noc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "NS(=O)(=O)c1cccc(C(=O)O)c1.O=S(Cl)Cl>>NS(=O)(=O)c1cccc(C(=O)Cl)c1",
        "output": "3"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O.O=Cc1ccc(S(=O)(=O)Cl)cc1.OCCOc1ccccc1.c1ccncc1>>O=Cc1ccc(S(=O)(=O)OCCOc2ccccc2)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC1(C)O[C@@H]2[C@H](O1)[C@@H](CNCCCNC(=O)Nc1ccc(C(C)(C)C)cc1)O[C@H]2n1cnc2c(N)ncnc21.ClCCCl.O=C([O-])O.O=CC1CC1.[Na+].[Na+]>>CC1(C)O[C@@H]2[C@H](O1)[C@@H](CN(CCCNC(=O)Nc1ccc(C(C)(C)C)cc1)CC1CC1)O[C@H]2n1cnc2c(N)ncnc21",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.CC(C)=O.NC(=O)N1c2ccccc2C[C@H](O)c2ccccc21.O>>CC(=O)O[C@H]1Cc2ccccc2N(C(N)=O)c2ccccc21",
        "output": "254"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNC1.CC(=O)SCC(CC(C)C)C(=O)Nc1cccc(C(=O)O)c1C.CO.Cl>>Cc1c(NC(=O)C(CS)CC(C)C)cccc1C(=O)O",
        "output": "90"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.Cn1c2c(c3ccc(Cl)c(Cl)c31)CN(C(=O)OC(C)(C)C)CC2.O=C(O)C(F)(F)F>>Cn1c2c(c3ccc(Cl)c(Cl)c31)CNCC2",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.OC[C@H]1C[C@H]2CN(c3ccc(Cl)cn3)CCN2C1.Oc1ccc(F)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Fc1ccc(OC[C@H]2C[C@H]3CN(c4ccc(Cl)cn4)CCN3C2)cc1",
        "output": "550"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCCCc1noc(CO)c1COc1cc(C(=O)OC)n(C)n1.O.[Na+].[OH-]>>CCCCc1noc(CO)c1COc1cc(C(=O)O)n(C)n1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.CCOC(C)=O.CN(C)CCN.COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(C(=O)O)c4OC)c4ccccc34)n2)cc(OC)c1.ClCCl>>COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(C(=O)NCCN(C)C)c4OC)c4ccccc34)n2)cc(OC)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)c1cc(-c2ccccc2)n(-c2ccc(OC(F)(F)F)cc2)c1C.Cl.[Na+].[OH-]>>Cc1c(C(=O)O)cc(-c2ccccc2)n1-c1ccc(OC(F)(F)F)cc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.COc1nc2[nH]ncc2cc1[N+](=O)[O-].[Pd]>>COc1nc2[nH]ncc2cc1N",
        "output": "269"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C)=O.CCCc1c(O)ccc2c1OCCC2=O.CCOC(=O)CCc1cc(C(=O)c2cccc(C(=O)OCC)c2)ccc1OCCCCCCBr.O=C([O-])[O-].[K+].[K+]>>CCCc1c(OCCCCCCOc2ccc(C(=O)c3cccc(C(=O)OCC)c3)cc2CCC(=O)OCC)ccc2c1OCCC2=O",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)C1CN(c2nc(C)nc3cc(Cl)c(Br)cc23)CCN1C(=O)OC(C)(C)C.Cl.O.O.[Li]O>>Cc1nc(N2CCN(C(=O)OC(C)(C)C)C(C(=O)O)C2)c2cc(Br)c(Cl)cc2n1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCc1ccc(S(=O)(=O)N2CCN(S(=O)(=O)c3ccc(N)cc3)CC2)cc1F.FC(F)(F)c1ccc2c(Cl)ccnc2c1>>CCCc1ccc(S(=O)(=O)N2CCN(S(=O)(=O)c3ccc(Nc4ccnc5cc(C(F)(F)F)ccc45)cc3)CC2)cc1F",
        "output": "115"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(NCCN(C)C)c1nc2scnc2c(=O)n1Cc1ccccc1.CCN(C(C)C)C(C)C.ClCCl.O=C(Cl)c1ccc(Br)cc1>>CCC(c1nc2scnc2c(=O)n1Cc1ccccc1)N(CCN(C)C)C(=O)c1ccc(Br)cc1",
        "output": "201"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.COc1ccc(N2CCCC(=O)CC2)cc1.ClCCl.O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCNC1.O=C([O-])O.[Na+].[Na+]>>COc1ccc(N2CCCC(N3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1",
        "output": "187"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)c2cccc3ccc(OCc4ccccc4)cc23)CC1.CO.[OH-].[OH-].[Pd+2]>>CC(C)(C)OC(=O)N1CCN(C(=O)c2cccc3ccc(O)cc23)CC1",
        "output": "23"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc2c(c1)[nH]c(=O)n2C1CCNCC1.O=C(O)C(F)(F)F.O=C(O)CCCc1nc2ccccc2c(=O)[nH]1>>Cc1ccc2c(c1)[nH]c(=O)n2C1CCN(C(=O)CCCc2nc3ccccc3c(=O)[nH]2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)N=C=O.CCN(CC)CC.Cc1cc(C)cc(Oc2ccc(C#N)cc2S(=O)(=O)N2CCNCC2)c1.ClCCl>>Cc1cc(C)cc(Oc2ccc(C#N)cc2S(=O)(=O)N2CCN(C(=O)NC(C)C)CC2)c1",
        "output": "437"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@H](O)C(=O)O.F[P-](F)(F)(F)(F)F.N#Cc1cc(-c2ncnc(Nc3scnc3CO)n2)ccc1O[C@H]1CCNC[C@H]1F.N#Cc1cccc(-c2ncnc(Nc3scnc3CO)n2)c1>>C[C@H](O)C(=O)N1CC[C@H](Oc2ccc(-c3ncnc(Nc4scnc4CO)n3)cc2C#N)[C@H](F)C1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCOc1ccc(-c2ccc(C(=O)Nc3ccccc3CP(=O)(OCC)OCC)cc2)cc1.C[Si](C)(C)I.Cc1ccccc1.ClCCl.[Na+].[OH-]>>CCCCCCCCOc1ccc(-c2ccc(C(=O)Nc3ccccc3CP(=O)(O)O)cc2)cc1",
        "output": "535"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COc1ccc(C(=O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)c(OC)c1OC.ClC(Cl)Cl.O.[BH4-].[Cl-].[NH4+].[Na+]>>COc1ccc(C(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)c(OC)c1OC",
        "output": "24"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)[C@@H]1CC[C@@H](c2nnc(-c3ccccc3)o2)CC1.[Na+].[OH-]>>O=C(O)[C@@H]1CC[C@@H](c2nnc(-c3ccccc3)o2)CC1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)NC[C@H](O)COc1ccc(O)cc1.CS(C)=O.Cl.Cl.ClCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1.Nc1c(F)c(N)c(F)c(F)c1F.[Na+].[OH-]>>CC(C)NC[C@H](O)COc1ccc(OCCN2CCN(CCCN3c4ccccc4Sc4ccc(Cl)cc43)CC2)cc1",
        "output": "74"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.NCCc1ccccc1.O=C(O)c1nc2c(C(F)(F)F)cc(-c3ccco3)cn2c1Cl>>O=C(NCCc1ccccc1)c1nc2c(C(F)(F)F)cc(-c3ccco3)cn2c1Cl",
        "output": "697"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cc(F)c(F)c(F)c1F.O=C([O-])O.[Na+]>>CCOC(=O)c1cc(F)c(F)c(F)c1F",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1cc(O)c2cc(C#C[Si](C)(C)C)cc(C#N)c2n1.COC(=O)c1nc2c([N+](=O)[O-])cccc2c(O)c1C#C[Si](C)(C)C>>C#Cc1cc(C#N)c2nc(C(=O)OC)cc(O)c2c1",
        "output": "337"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCCCC.CCOC(C)=O.CO.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4ccccc4F)c3)c3cc(-c4cccc(NS(C)(=O)=O)c4)cnc32)cc1.O.[Li+].[OH-]>>CS(=O)(=O)Nc1cccc(-c2cnc3[nH]cc(-c4cnn(Cc5ccccc5F)c4)c3c2)c1",
        "output": "949"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOCC.COC(=O)c1sc(-n2cnc3cc(OC)ncc32)cc1OCc1ccccc1C(F)(F)F.COC(=O)c1sc(-n2cnc3cnc(OC)cc32)cc1OCc1ccccc1C(F)(F)F.[Li+].[Na+].[OH-].[OH-]>>COc1cc2c(cn1)ncn2-c1cc(OCc2ccccc2C(F)(F)F)c(C(=O)O)s1",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC1(C#N)CCOCC1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC1(CN)CCOCC1",
        "output": "246"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)CCCC=CCC1C(O)CC(O)C1COC(=S)NCc1ccccc1.O.[Li+].[OH-]>>O=C(O)CCCC=CCC1C(O)CC(O)C1COC(=S)NCc1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1C(F)(F)F)C(=O)O.CCN(C(C)C)C(C)C.Cc1c(Cl)nn(C)c1-c1csc(C(=O)O)c1.ClC(Cl)Cl.F[P-](F)(F)(F)(F)F.N[C@@H](CC1CCCCC1)CN1C(=O)c2ccccc2C1=O>>Cc1c(Cl)nn(C)c1-c1csc(C(=O)N[C@@H](CC2CCCCC2)CN2C(=O)c3ccccc3C2=O)c1",
        "output": "736"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[C@H](N)C(=O)N1C[C@@H]2C[C@H]1CN2C(=O)c1ccc(-c2ccccc2)cn1.CN1CCOCC1.ClCCCl.ClCCl.O=C(O)c1cc2cc(F)ccc2[nH]1.On1nnc2ccccc21>>CC(C)(C)[C@H](NC(=O)c1cc2cc(F)ccc2[nH]1)C(=O)N1C[C@@H]2C[C@H]1CN2C(=O)c1ccc(-c2ccccc2)cn1",
        "output": "738"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(N)cc1N(C)C.Nc1nc(-c2cccc(NC(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Cl)n2)s1>>COc1ccc(Nc2nccc(-c3sc(N)nc3-c3cccc(NC(=O)c4c(F)cccc4F)c3)n2)cc1N(C)C",
        "output": "907"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#Cc1ccccc1.CC#N.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.I[Cu]I.N#Cc1cc(Br)ccc1N.N#Cc1ccccc1Br>>N#Cc1cc(C#Cc2ccccc2)ccc1N",
        "output": "659"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCc1ccc(-c2ccccc2)cc1.CCN(C(C)C)C(C)C.CN(C)C=O.Cn1c(=O)n(Cc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)c2cc(I)ccc21.O.[Cu]I>>Cn1c(=O)n(Cc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)c2cc(C#CCc3ccc(-c4ccccc4)cc3)ccc21",
        "output": "664"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O.Cl.NO>>CCCCCCCCCCOc1ccc(C(=NO)c2cccc(C(=O)O)c2)cc1CCC(=O)O",
        "output": "190"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccccc1.CC(=O)[O-].CC(=O)[O-].Cc1ccccc1.O=C([O-])[O-].O=C1CCCN1.[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>O=C1CCCN1c1ccccc1",
        "output": "809"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.CCCCc1nc2ccnn2c(=O)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.CO.Cl.O>>CCCCc1nc2ccnn2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1",
        "output": "815"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Clc1nccc(-c2cccnc2)n1.Nc1ccc(O)cc1[N+](=O)[O-]>>Nc1ccc(Oc2nccc(-c3cccnc3)n2)cc1[N+](=O)[O-]",
        "output": "542"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)(CN)CC1.CCOC(=O)C(F)(F)Br.CCOC(C)=O.CN(C)C=O.O.O.[Cl-].[Na+]>>CC(C)(C)OC(=O)N1CCC(O)(CNC(=O)C(F)(F)Br)CC1",
        "output": "64"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCBr.COc1cc(F)c(N2CCNCC2)cc1F.CS(=O)(=O)OCCCC1CCCCC1.Fc1cc(N2CCNCC2)ccc1OCc1ccccc1>>COc1cc(F)c(N2CCN(CCCC3CCCCC3)CC2)cc1F",
        "output": "496"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)CCc1cccc(C(F)(F)F)c1.NN.O>>NNC(=O)CCc1cccc(C(F)(F)F)c1",
        "output": "164"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)C(=O)NC(=O)N1CCNc1ncc(Br)c(-c2ccc(Cl)s2)n1.Nc1cccc(B(O)O)c1>>CC1(C)C(=O)NC(=O)N1CCNc1ncc(-c2cccc(N)c2)c(-c2ccc(Cl)s2)n1",
        "output": "871"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)OC(=O)N1CCC(CCO)CC1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)OC(=O)N1CCC(CCOS(C)(=O)=O)CC1",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)Cc1cccc(Oc2ccc(F)cc2CN2CCOC2=O)c1.CO.O.[Li+].[OH-]>>O=C(O)Cc1cccc(Oc2ccc(F)cc2CN2CCOC2=O)c1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)O.CCCC[N+](CCCC)(CCCC)CCCC.Cc1c(C)c2c(c(C)c1O[Si](C)(C)C(C)(C)C)SC(CCCC(C)(C)C(=O)O)O2.O.O.O.[F-]>>Cc1c(C)c2c(c(C)c1O)SC(CCCC(C)(C)C(=O)O)O2",
        "output": "754"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2ccn(CC(=O)O)n2)cc1Cl.Cc1cccc(C)n1.ClCCl.O=C(Cl)C(=O)Cl>>CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2ccn(CC(=O)N3CCOCC3)n2)cc1Cl",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CO.Fc1ccc(N2CCNCC2)cc1.O=C(O)c1cc2[nH]nc(-c3cc4cc(CO)ccc4[nH]3)c2s1.On1nnc2ccccc21>>O=C(c1cc2[nH]nc(-c3cc4cc(CO)ccc4[nH]3)c2s1)N1CCN(c2ccc(F)cc2)CC1",
        "output": "857"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(Cc1cccc(Br)c1)C(=O)OC(C)(C)C.Cc1cc(C=O)ccc1B(O)O>>Cc1cc(C=O)ccc1-c1cccc(CN(C)C(=O)OC(C)(C)C)c1",
        "output": "908"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.CN.Cl.O.O=C(Nc1nc(-c2c(F)c(F)c(F)c(F)c2F)c(C(=O)O)s1)c1cc(Br)ccc1O.On1nnc2ccccc21>>CNC(=O)c1sc(NC(=O)c2cc(Br)ccc2O)nc1-c1c(F)c(F)c(F)c(F)c1F",
        "output": "534"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(C)(C)c1ccc(Br)cc1.CN(C)C=O.[Li]CCCC>>CCC(C)(C)c1ccc(C=O)cc1",
        "output": "638"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.Nc1ncnc2c1c(I)nn2C1CCCNC1.O.[Na+].[Na+].[OH-]>>CN1CCCC(n2nc(I)c3c(N)ncnc32)C1",
        "output": "217"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.Cc1cc(COC(=O)N2CCC(NC(=O)OC(C)(C)C)CC2)cc(C(F)(F)F)c1.Cl.ClCCl>>Cc1cc(COC(=O)N2CCC(N)CC2)cc(C(F)(F)F)c1",
        "output": "538"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)C1(NC(=O)C(NC(=O)Cn2nc(-c3ccc(Cl)cc3)n(C3CC3)c2=O)c2cccc(C(F)(F)F)c2)CC1.CO.CS(C)=O.Cl.[Li+].[Na+].[OH-].[OH-]>>O=C(Cn1nc(-c2ccc(Cl)cc2)n(C2CC2)c1=O)NC(C(=O)NC1(C(=O)O)CC1)c1cccc(C(F)(F)F)c1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc2c(c1)CN(C(=O)OC(C)(C)C)C2.[Na+].[OH-]>>CC(C)(C)OC(=O)N1Cc2ccc(C(=O)O)cc2C1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.NC1CCN(Cc2ccc(Cl)c(F)c2)CC1.O=C(O)CCc1nc(-c2ccccn2)no1.O=C([O-])O.[Na+]>>O=C(CCc1nc(-c2ccccn2)no1)NC1CCN(Cc2ccc(Cl)c(F)c2)CC1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCNCC.Cc1cc(Nc2cc3cc(C(=O)O)ccc3c(OC(C)C)n2)n[nH]1.ClCCl.On1nnc2ccccc21>>CCN(CC)C(=O)c1ccc2c(OC(C)C)nc(Nc3cc(C)[nH]n3)cc2c1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1C[C@H]2CCNc3ccccc3[C@@H]2C1.CN(C)C=O.O=C1CCC(=O)N1Cl>>CC(C)(C)OC(=O)N1C[C@H]2CCNc3ccc(Cl)cc3[C@@H]2C1",
        "output": "121"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CN1C2CCC1CC(=O)C2.Cc1ccc(Br)cc1.[Li]CCCC>>Cc1ccc(C2(O)CC3CCC(C2)N3C)cc1",
        "output": "321"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCc1cn2c(C(=O)c3ccc(-c4ccccc4C(=O)OC(C)(C)C)cc3)cccc2n1.O=C(O)C(F)(F)F>>CCc1cn2c(C(=O)c3ccc(-c4ccccc4C(=O)O)cc3)cccc2n1",
        "output": "752"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(C)=O.Cl.O.O=C(O)c1ccc(Cl)cc1O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1ccc(Cl)cc1O",
        "output": "72"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOc1c(C(C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(C#N)c1C1CNC1.O=C([O-])O.OCCBr.[Na+]>>CCOc1c(C(C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(C#N)c1C1CN(CCO)C1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.COc1ccccc1C(C)C.O=C1CCC(=O)N1Br>>COc1ccc(Br)cc1C(C)C",
        "output": "4"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCn1nc(C(=O)OCC)cc1CCS(=O)(=O)CCC.CCO.[Na+].[OH-]>>CCCCn1nc(C(=O)O)cc1CCS(=O)(=O)CCC",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC[SiH](CC)CC.COc1ccc(S(=O)(=O)N(CC(=O)OC(C)(C)C)c2cc(N(C)C)ccc2Cl)cc1OC.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(S(=O)(=O)N(CC(=O)O)c2cc(N(C)C)ccc2Cl)cc1OC",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N#CCc1ccc2cc(NC(=O)OCc3ccccc3)c(C(=O)O)nc2c1.Nc1cnccc1N1CCC[C@H](NC(=O)OCc2ccccc2)C1>>N#CCc1ccc2cc(NC(=O)OCc3ccccc3)c(C(=O)Nc3cnccc3N3CCC[C@H](NC(=O)OCc4ccccc4)C3)nc2c1",
        "output": "776"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)/C=C/C(=O)c1nn(-c2ccc(OCC(F)(F)F)cc2)ccc1=O.NNc1cccc(F)c1>>O=c1ccn(-c2ccc(OCC(F)(F)F)cc2)nc1-c1ccnn1-c1cccc(F)c1",
        "output": "984"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC(N2CCC(N[C@H]3CCCC[C@@H]3CN=[N+]=[N-])CC2)CC1.CO.[Cl-].[NH4+].[Zn]>>CC(C)(C)OC(=O)N1CCC(N2CCC(N[C@H]3CCCC[C@@H]3CN)CC2)CC1",
        "output": "89"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.NCC1Cc2cccc(-c3c(Cl)cc(Cl)cc3Cl)c2O1.O=C(Cl)OCc1ccccc1>>O=C(NCC1Cc2cccc(-c3c(Cl)cc(Cl)cc3Cl)c2O1)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.OC[C@@H]1C[C@H]1CN1CCN(c2csc3cc(C(F)(F)F)ccc23)CC1>>O=C[C@@H]1C[C@H]1CN1CCN(c2csc3cc(C(F)(F)F)ccc23)CC1",
        "output": "142"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cc1cc(C)c(CN)c(=O)[nH]1.Cl.ClCCl.N#Cc1c(Oc2ccc(C(=O)O)cc2Cl)cccc1-c1ccnnc1.O.On1nnc2ccccc21>>Cc1cc(C)c(CNC(=O)c2ccc(Oc3cccc(-c4ccnnc4)c3C#N)c(Cl)c2)c(=O)[nH]1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CC1(C#N)CCC2(CC1)OCCO2.O.O=C([O-])O.[Cl-].[Na+].[Na+]>>CC1(C#N)CCC(=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=CC1C(C(=O)Cl)C1(C)C.CCCCCC.CCOCC.Cc1c(CO)cccc1-c1ccccc1.c1ccncc1>>CC(C)=CC1C(C(=O)OCc2cccc(-c3ccccc3)c2C)C1(C)C",
        "output": "126"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)c1ccc(OCc2ccccc2)c(C(C)(C)CCO)c1.ClCCl>>CC(C)(C)c1ccc(OCc2ccccc2)c(C(C)(C)CC=O)c1",
        "output": "142"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)Cc1c(C)c(Cc2ccc(Cl)cc2)c2cc(C#N)ccn12.CO.[Na+].[OH-]>>Cc1c(Cc2ccc(Cl)cc2)c2cc(C#N)ccn2c1CC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1ccc(OCCCN(C(=O)CCC(=O)O)c2ccc(Cl)cc2)cc1.Cl.[Na+].[OH-]>>O=C(O)CCC(=O)N(CCCOc1ccc(C(=O)O)cc1)c1ccc(Cl)cc1",
        "output": "222"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.N#Cc1ccc(OCCC(=O)O)cc1.O=S(Cl)Cl>>COC(=O)CCOc1ccc(C#N)cc1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1nc2cc(/C=C/C3CC[NH2+]CC3)ccc2c(=O)o1.O=C(O)Cc1ccc(-n2cnnn2)cc1.[Cl-]>>Cc1nc2cc(/C=C/C3CCN(C(=O)Cc4ccc(-n5cnnn5)cc4)CC3)ccc2c(=O)o1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)c1nc(CC2(c3ccccc3)CCCC2)nc(O)c1OCc1ccccc1.O=C(O)c1nc(Cc2ccccc2-c2ccccc2)nc(O)c1OCc1ccccc1>>O=C(O)c1nc(CC2(c3ccccc3)CCCC2)nc(O)c1OCc1ccccc1",
        "output": "569"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCNC.CCOCCn1nc(C(=O)NS(C)(=O)=O)c2nc(Cl)nc(Nc3cc(C)ccn3)c21.CS(C)=O.[Cs+].[F-]>>CCOCCn1nc(C(=O)NS(C)(=O)=O)c2nc(N(C)CC)nc(Nc3cc(C)ccn3)c21",
        "output": "36"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.O=C(Cl)c1ccc(F)cc1.c1c[nH]c(-c2nc([C@H]3CCCNC3)no2)c1>>O=C(c1ccc(F)cc1)N1CCC[C@H](c2noc(-c3ccc[nH]3)n2)C1",
        "output": "201"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCC.COc1cc(OC)c(-c2ccnn2-c2ccccc2Cl)cc1CCc1cccc(C(=O)O)c1>>O=C(O)c1cccc(CCc2cc(-c3ccnn3-c3ccccc3Cl)c(O)cc2O)c1",
        "output": "20"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)CCN.CCOC(C)=O.Cl.O=[N+]([O-])c1cccc([N+](=O)[O-])c1Cl>>CCOC(=O)CCNc1c([N+](=O)[O-])cccc1[N+](=O)[O-]",
        "output": "304"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COc1cc(CC(=O)O)cc(OC)c1.O=S(=O)(O)O>>CCOC(=O)Cc1cc(OC)cc(OC)c1",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)Cl.Nc1ccc(C=CCN2CCC(=C3c4ccccc4C=Cc4ccccc43)CC2)cc1>>CS(=O)(=O)Nc1ccc(C=CCN2CCC(=C3c4ccccc4C=Cc4ccccc43)CC2)cc1",
        "output": "194"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(Br)cc1C(C)=O.ClCCl>>COc1ccc(Br)cc1C(C)O",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)(C)OC(=O)NNC(=O)C1(c2ccc(Br)cc2)CC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.[K+]>>CC(C)(C)OC(=O)NNC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1",
        "output": "942"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COCCl.O.O=C([O-])[O-].Oc1ccccc1Br.[Na+].[Na+]>>COCOc1ccccc1Br",
        "output": "375"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(C)=O.CO.O=Cc1ccc(OCc2ccccc2)cc1.[Na+].[OH-]>>CCC(=O)C=Cc1ccc(OCc2ccccc2)cc1",
        "output": "295"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)OC(=O)Nc2cc(OCCCCSc3ccc(Cl)c(Cl)c3)ccc21.OO>>CC1(C)OC(=O)Nc2cc(OCCCCS(=O)c3ccc(Cl)c(Cl)c3)ccc21",
        "output": "199"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(CCN(C(N)=O)C1CCN(C(=O)OCc2ccccc2)CC1)OCC.CO.[Pd]>>CCOC(CCN(C(N)=O)C1CCNCC1)OCC",
        "output": "428"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COc1ccc(N2CCC(N(C)Cc3ccccc3)CC2)cn1>>CNC1CCN(c2ccc(OC)nc2)CC1",
        "output": "84"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=c1[nH]c2c3ccccc3ncc2n1C1CCN(Cc2ccccc2)CC1.[Pd]>>O=c1[nH]c2c3ccccc3ncc2n1C1CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCS(=O)(=O)Cl.ClCCl.c1cc(-c2noc(C3CCNCC3)n2)ccn1.c1ccncc1>>CCCCS(=O)(=O)N1CCC(c2nc(-c3ccncc3)no2)CC1",
        "output": "584"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)CC(=O)c1cccc(-c2cncnc2)c1.CCCN(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1C(F)(F)F>>CCCN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3cncnc3)c2)cc1C(F)(F)F",
        "output": "929"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)Cc1cccc(O)c1.CCOC(C)=O.CN(C)C=O.FC(F)(F)c1ccc(CBr)cc1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)Cc1cccc(OCc2ccc(C(F)(F)F)cc2)c1",
        "output": "127"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CN(C)c1ccncc1.COC(=O)c1ccc(N)cc1.F[P-](F)(F)(F)(F)F.O=C(O)COc1ccc(Cl)cc1Cl.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>COC(=O)c1ccc(NC(=O)COc2ccc(Cl)cc2Cl)cc1",
        "output": "710"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.I.O.O=C([O-])O.[Na+].c1ccc2[nH]c(N3CCCNCC3)nc2c1>>CC(C)(C)OC(=O)N1CCCN(c2nc3ccccc3[nH]2)CC1",
        "output": "694"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C(=O)OCc1ccccc1)c1ccc(-c2ccc(N)cc2)c(F)c1.CCN(CC)CC.ClCCl.O=C(Cl)CCl>>CC(C(=O)OCc1ccccc1)c1ccc(-c2ccc(NC(=O)CCl)cc2)c(F)c1",
        "output": "9"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)CCc1ccc(C#N)cc1Cl.[K+].[OH-]>>N#Cc1ccc(CCC(=O)O)c(Cl)c1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cc(-c2ccc(F)c(Cl)c2)n(-c2ccc(F)c(Cl)c2)n1.O=C(O)c1cc(-c2cc(F)cc(Cl)c2)n(-c2ccc(F)c(Cl)c2)n1>>O=C(O)c1cc(-c2ccc(F)c(Cl)c2)n(-c2ccc(F)c(Cl)c2)n1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.O.O=C(Cl)OCc1ccccc1.O=C([O-])[O-].OC[C@H]1CCCN1.[Na+].[Na+]>>O=C(OCc1ccccc1)N1CCC[C@@H]1CO",
        "output": "427"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1CCOCC1.CNOC.Cl.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)Cc1ccc(OC2CCCCC2)cc1>>CON(C)C(=O)Cc1ccc(OC2CCCCC2)cc1",
        "output": "54"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.N#CCC(=O)O.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1F)nn2C[C@@H]1CC(F)(F)CN1>>N#CCC(=O)N1CC(F)(F)C[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCC.CCCc1n[nH]c2ccc(Br)cc12.CCOCC.O=C=O.[Li]C(C)(C)C>>CCCc1n[nH]c2ccc(C(=O)O)cc12",
        "output": "654"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=Cc1ccc(=O)[nH]c1.CN1CCCC1=O.Cc1ccc2[nH]c3c(c2c1)CN(C)CC3.[K+].[OH-]>>Cc1ccc2c(c1)c1c(n2CCc2ccc(=O)[nH]c2)CCN(C)C1",
        "output": "986"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COCC1CN(C(=O)OC(C)(C)C)CCC1NC(=O)c1ccccc1.ClCCl.O=C(O)C(F)(F)F>>COCC1CNCCC1NC(=O)c1ccccc1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CN(C)C=O.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(F)cc1O.[NH4+].[OH-]>>NC(=O)c1ccc(F)cc1O",
        "output": "358"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N([C@@H]1C[C@H]1c1ccccc1)CC(F)(F)C(=O)N2C.[Cl-].[NH4+]>>COc1cc(C(N)=O)ccc1Nc1ncc2c(n1)N([C@@H]1C[C@H]1c1ccccc1)CC(F)(F)C(=O)N2C",
        "output": "358"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(-c3cncc(CC(=O)OC)c3)cc2)cc1C)CC.CO.[Cl-].[NH4+].[Na+].[OH-]>>CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(-c3cncc(CC(=O)O)c3)cc2)cc1C)CC",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COc1ccc(-c2nn(COCC[Si](C)(C)C)c3c2Cc2sc(-c4ccc(OC)c(OC)c4)cc2-3)cc1.Cl>>COc1ccc(-c2n[nH]c3c2Cc2sc(-c4ccc(OC)c(OC)c4)cc2-3)cc1",
        "output": "813"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1cn(-c2ccc(C(F)(F)F)cc2)nc1C(C)C.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>CC(C)c1nn(-c2ccc(C(F)(F)F)cc2)cc1CO",
        "output": "471"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CN2CCC(CC2)N1.CCN(CC)CC.ClCCl.O=C(Cl)Oc1ccc(Br)cc1>>O=C(Oc1ccc(Br)cc1)N1CCN2CCC1CC2",
        "output": "219"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CNC1.CC(C)Oc1cc(Oc2ccc(C(=O)O)cc2F)cc(C(=O)Nc2ccn(C)n2)c1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O>>CC(C)Oc1cc(Oc2ccc(C(=O)N3CCC3)cc2F)cc(C(=O)Nc2ccn(C)n2)c1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCNc1ccc(-c2nc(-c3ccc4c(c3)CCN(C(=O)CNC(=O)OC(C)(C)C)CC4)no2)cc1C#N.ClCCl.O=C(O)C(F)(F)F>>CCCNc1ccc(-c2nc(-c3ccc4c(c3)CCN(C(=O)CN)CC4)no2)cc1C#N",
        "output": "431"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)OC(=O)CCCCCBr.Oc1ccc2nc(-c3ccccc3)n(Cc3ccccc3)c2c1>>CC(C)OC(=O)CCCCCOc1ccc2nc(-c3ccccc3)n(Cc3ccccc3)c2c1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCc1c(C(=O)NC2CC2)nnn1-c1ccc(N)cc1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)CC(=O)O.Cl.ClCCl.On1nnc2ccccc21>>CCCc1c(C(=O)NC2CC2)nnn1-c1ccc(NC(=O)CN(C)C)cc1",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCOCc1nc2c(N)nc3ccccc3c2n1CCOCCN.ClCCl.O.O=C(Cl)c1ccccc1>>CCOCc1nc2c(N)nc3ccccc3c2n1CCOCCNC(=O)c1ccccc1",
        "output": "271"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(Cc1cccc(C(=O)O)c1)NC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(O)c(CO)c1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl.NCCc1ccc(Cl)cc1.O.On1nnc2ccccc21>>CC(C)(Cc1cccc(C(=O)NCCc2ccc(Cl)cc2)c1)NC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(O)c(CO)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCc1c(OCC(=O)OC)ccc(C)[n+]1[O-].CO.[Na+].[OH-]>>CCc1c(OCC(=O)O)ccc(C)[n+]1[O-]",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)CCCc1cn(C(C)(C)C)s/c1=N\\C(=O)c1cccc(C(F)(F)F)c1F.C[Mg]Br.[Ce+3].[Cl-].[Cl-].[Cl-]>>CC(C)(O)CCCc1cn(C(C)(C)C)s/c1=N\\C(=O)c1cccc(C(F)(F)F)c1F",
        "output": "514"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.COC(=O)CBr.COCOc1cc(CCC(=O)c2c(OC)cc(OC)c(CCC(C)C)c2O)ccc1OC.[H-].[Na+]>>COCOc1cc(CCC(=O)c2c(OC)cc(OC)c(CCC(C)C)c2OCC(=O)OC)ccc1OC",
        "output": "557"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CN(C)C=O.O.O=C(NCC1CC1)c1cc(Oc2ccc([N+](=O)[O-])cc2)ccn1.[Cl-].[Fe].[NH4+]>>Nc1ccc(Oc2ccnc(C(=O)NCC3CC3)c2)cc1",
        "output": "335"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N1CCNCC1.CCOC(C)=O.CN(C)C=O.COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCOCCBr>>COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCOCCN1CCN(C(C)=O)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)C1CN(Cc2ccccc2)CCN1Cc1ccccc1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OCC1CN(Cc2ccccc2)CCN1Cc1ccccc1",
        "output": "430"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC(C)(C)OC(=O)Nc1ccc(O)c2ccccc12.ClCCCBr.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)Nc1ccc(OCCCCl)c2ccccc12",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.Clc1ccc(OC2CCNCC2)cc1Cl.O=C1c2ccccc2C(=O)N1CCC1CO1>>O=C1c2ccccc2C(=O)N1CCC(O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1",
        "output": "76"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.Cc1ccccc1.O=C(Cl)c1ccccc1.OC1CCN(Cc2ccccc2Br)CC1>>O=C(OC1CCN(Cc2ccccc2Br)CC1)c1ccccc1",
        "output": "51"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(O)CN.O=S1CCN(c2nc(Cl)nc3c(NCc4cccnc4)ncnc23)CC1>>CC(O)CNc1nc(N2CCS(=O)CC2)c2ncnc(NCc3cccnc3)c2n1",
        "output": "544"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.C[C@@H]1CCCN[C@@H]1CN1C(=O)c2ccccc2C1=O.F[P-](F)(F)(F)(F)F.O=C(O)c1cc(F)ccc1I>>C[C@@H]1CCCN(C(=O)c2cc(F)ccc2I)[C@@H]1CN1C(=O)c2ccccc2C1=O",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC(N)C1.CCOCCn1c(=O)c(C#N)c(Cl)c2ccccc21.[H-].[Na+]>>CCOCCn1c(=O)c(C#N)c(NC2CN(C(=O)OC(C)(C)C)C2)c2ccccc21",
        "output": "78"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1ccc(OCCCF)nc1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1ccc(OCCCF)nc1",
        "output": "522"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(Cc1ccc2ccccc2c1)Nc1ccc([N+](=O)[O-])cc1Cl.Cl.O.[Fe]>>CC(C)(Cc1ccc2ccccc2c1)Nc1ccc(N)cc1Cl",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.O=C(O)C(F)(F)F.O=c1cc(O)c2c(Cc3ccccc3)ncnc2n1OCc1ccccc1>>O=c1cc(O)c2c(Cc3ccccc3)ncnc2n1O",
        "output": "630"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O.O=C(Nc1ccnc(Cl)c1)c1cccc2c1Cc1ccccc1-2.c1ccc(CN2CCNCC2)cc1>>O=C(Nc1ccnc(N2CCN(Cc3ccccc3)CC2)c1)c1cccc2c1Cc1ccccc1-2",
        "output": "220"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)C(=O)Cl.CCCc1c(C(=O)NC2CC2)nnn1-c1ccc(N)cc1.ClCCl.c1ccncc1>>CCCc1c(C(=O)NC2CC2)nnn1-c1ccc(NC(=O)C(C)C)cc1",
        "output": "9"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C1CC1C=O.CO.[BH4-].[Na+]>>CCOC(=O)C1CC1CO",
        "output": "223"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)O.Cn1ccc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3C=O)cn(C)c2=O)n1.O.[Li+].[OH-]>>Cn1ccc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3CO)cn(C)c2=O)n1",
        "output": "476"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cc(C(=O)O)cc(S(F)(F)(F)(F)F)c2)CC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.Cc1ccc(N)cc1-n1ccn2nc(-c3cn[nH]c3)cc12.F[P-](F)(F)(F)(F)F.N>>Cc1ccc(NC(=O)c2cc(N3CCN(C(=O)OC(C)(C)C)CC3)cc(S(F)(F)(F)(F)F)c2)cc1-n1ccn2nc(-c3cn[nH]c3)cc12",
        "output": "50"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.ClCc1ccccc1.O=Cc1ccc(O)cc1O.[F-].[K+]>>O=Cc1ccc(OCc2ccccc2)cc1O",
        "output": "49"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C[C@@H]1CCCN1CCc1ccc(B(O)O)cc1.O=S(=O)(c1ccc(Br)cc1)C1CCCC1>>C[C@@H]1CCCN1CCc1ccc(-c2ccc(S(=O)(=O)C3CCCC3)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNC1.Clc1ccc(-c2nsc3cc(OCCCCBr)ccc23)cc1>>Clc1ccc(-c2nsc3cc(OCCCCN4CCC4)ccc23)cc1",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCC.Cc1nc(CN=[N+]=[N-])ccc1OCc1ccccc1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>Cc1nc(CN)ccc1OCc1ccccc1",
        "output": "89"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCCCCCCc1cccc(OCc2ccccc2)c1OCc1ccccc1.CCOC(=O)C(=O)c1ccc(O)cc1.CN(C)C=O.[H-].[Na+]>>CCOC(=O)C(=O)c1ccc(OCCCCCCc2cccc(OCc3ccccc3)c2OCc2ccccc2)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)c1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2/C=C/c2ccc(Br)cc2)cc1.COc1ccc(B(O)O)cn1>>COC(=O)c1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2/C=C/c2ccc(-c3ccc(OC)nc3)cc2)cc1",
        "output": "899"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.O.O=C(O)c1cccc2oc(-c3cccc([N+](=O)[O-])c3)nc12.On1nnc2ccccc21.[Cl-].[NH4+]>>NC(=O)c1cccc2oc(-c3cccc([N+](=O)[O-])c3)nc12",
        "output": "704"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C(C)(C)c1cc2ccccc2[nH]1.O=S(=O)(O)O.O=[N+]([O-])[O-].[Na+]>>CCOC(=O)C(C)(C)c1cc2cc([N+](=O)[O-])ccc2[nH]1",
        "output": "103"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.NCCCn1ccnc1.O=C(O)c1n[nH]c2ccccc12.O=C(n1ccnc1)n1ccnc1>>O=C(NCCCn1ccnc1)c1n[nH]c2ccccc12",
        "output": "816"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCC1CC1.CN(C)C=O.Ic1c[nH]cn1.O=C([O-])[O-].[Cs+].[Cs+]>>Ic1cn(CC2CC2)cn1",
        "output": "495"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CC(=O)Cl.CCN(CC)CC.CCc1cc(Cl)c(Cl)cc1NCC(=O)N1CCNCC1.Cl.ClCCl>>C=CC(=O)N1CCN(C(=O)CNc2cc(Cl)c(Cl)cc2CC)CC1",
        "output": "135"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CCNCC2)CC1.CCOC(=O)c1cc2ccccn2c1C=O>>CCOC(=O)c1cc2ccccn2c1CN1CCC2(CC1)CCN(C(=O)OC(C)(C)C)CC2",
        "output": "829"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(NC(=O)Nc2cccc3c(Br)cccc23)cc1N1CCN(C)CC1.OB(O)c1cccnc1>>COc1ccc(NC(=O)Nc2cccc3c(-c4cccnc4)cccc23)cc1N1CCN(C)CC1",
        "output": "899"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.NCCN(CCN(Cc1ccccc1O)Cc1ccccc1O)Cc1ccc([N+](=O)[O-])cc1.[Pd]>>NCCN(CCN(Cc1ccccc1O)Cc1ccccc1O)Cc1ccc(N)cc1",
        "output": "507"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1cc2c(Cl)ncnc2cc1OCCCl.Cc1[nH]c2ccc(O)cc2c1C.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(Oc3ccc4[nH]c(C)c(C)c4c3)ncnc2cc1OCCCl",
        "output": "668"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.COc1nc(-c2nc3n(n2)CCCC3C(=O)O)ccc1-n1cnc(C)c1.Cl.Nc1ccccc1.O.On1nnc2ccccc21>>COc1nc(-c2nc3n(n2)CCCC3C(=O)Nc2ccccc2)ccc1-n1cnc(C)c1",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC(C)(C)c1cc(CN)n(-c2cccc(Cl)c2)n1.CCN(CC)CC.COCCOc1ccc(NC(=O)Oc2ccccc2)cn1>>COCCOc1ccc(NC(=O)NCc2cc(C(C)(C)C)nn2-c2cccc(Cl)c2)cn1",
        "output": "488"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.Cn1cnc2ccc(O)cc21.O=C([O-])[O-].O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F.[K+].[K+]>>Cn1cnc2ccc(OS(=O)(=O)C(F)(F)F)cc21",
        "output": "843"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCC.CO.Cl.O=C(O)Cc1c[nH]c2ccccc12>>COC(=O)Cc1c[nH]c2ccccc12",
        "output": "195"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCN(C(=O)C1CCCCC1C(=O)Cl)c1ccc(-n2ccnc2)cc1.CCNCC>>CCCN(C(=O)C1CCCCC1C(=O)N(CC)CC)c1ccc(-n2ccnc2)cc1",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CCO.COc1cc2oc(=O)c3c(c2cc1OCCCOS(C)(=O)=O)CCC3.Cc1cccc(N2CCNCC2)c1C.O=C([O-])/C=C/C(=O)[O-]>>COc1cc2oc(=O)c3c(c2cc1OCCCN1CCN(c2cccc(C)c2C)CC1)CCC3",
        "output": "496"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=CCC/C(C)=C/COc1ccc(C(=O)O)cc1.CCN(CC)CC.COc1ccc(SCCN)nc1.ClC(Cl)Cl.O=P(Cl)(c1ccccc1)c1ccccc1>>COc1ccc(SCCNC(=O)c2ccc(OC/C=C(\\C)CCC=C(C)C)cc2)nc1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C(=O)O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.CC(C)CN.ClCCCl.ClCCl.On1nnc2ccccc21>>CC(C)CNC(=O)C(C)(C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.COc1ccc(F)cc1-n1c2ccccc2c2ccccc21.ClCCl.O=C([O-])O.[Na+].[Na+].[OH-]>>Oc1ccc(F)cc1-n1c2ccccc2c2ccccc21",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OCCCCCCCCCCCCCCCCCO.ClCCl.II.c1c[nH]cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccccc1>>CC(=O)OCCCCCCCCCCCCCCCCCI",
        "output": "670"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)CN1C(=O)CCc2cc(SCc3cc(-c4ccc(C(F)(F)F)cc4)on3)ccc21.O=C(O)COc1ccc(SCCCC(=O)c2ccc(Cl)cc2)c2c1CCC2>>O=C(O)CN1C(=O)CCc2cc(SCc3cc(-c4ccc(C(F)(F)F)cc4)on3)ccc21",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.Cn1nccc1-c1cc(N)ccc1OCCN1CCC1.O=C=Nc1ccc(F)cc1F>>Cn1nccc1-c1cc(NC(=O)Nc2ccc(F)cc2F)ccc1OCCN1CCC1",
        "output": "804"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C=CCC(CCOCc1ccccc1)O[Si](CC)(CC)CC.C[N+]1([O-])CCOCC1.O.O=[Os](=O)(=O)=O.[Na+].[O-][I+3]([O-])([O-])[O-]>>CC[Si](CC)(CC)OC(CC=O)CCOCc1ccccc1",
        "output": "571"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.CCOC(=O)CF.Cl.ClCCl>>O=C(CF)N1CCOCC1",
        "output": "494"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)C1Cc2c(n(C)c3ccc(OC)cc23)C1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1ccc2c(c1)c1c(n2C)CC(CO)C1",
        "output": "225"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1ccc(-c2ccc3c(c2)CCN(CCN2CCC[C@H]2C)C3=O)c(F)c1>>C[C@@H]1CCCN1CCN1CCc2cc(-c3ccc(C(=O)O)cc3F)ccc2C1=O",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(CC2NCCSc3cc(OC)c(OC)cc32)cc1OC.NC1CCCc2ccccc21.O=C(Br)CBr>>COc1ccc(CC2c3cc(OC)c(OC)cc3SCCN2CC(=O)NC2CCCc3ccccc32)cc1OC",
        "output": "946"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(=O)(=O)Cl.O=C1N=C(N2CCCNCC2)SC1=Cc1ccc2c(cnn2Cc2ccc(Cl)cc2C(F)(F)F)c1>>CS(=O)(=O)N1CCCN(C2=NC(=O)C(=Cc3ccc4c(cnn4Cc4ccc(Cl)cc4C(F)(F)F)c3)S2)CC1",
        "output": "584"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)c1cccc(C(C)C)c1N.COC(=O)c1cc(C)cc2c1OCc1ccccc1C2C(=O)O>>COC(=O)c1cc(C)cc2c1OCc1ccccc1C2C(=O)Nc1c(C(C)C)cccc1C(C)C",
        "output": "365"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(Nc2ncc(OCC#N)cn2)CC1.ClCCl.O=C(O)C(F)(F)F>>N#CCOc1cnc(NC2CCNCC2)nc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC[C@@H](C)Oc1cc(OCc2ccccc2)cc(C(=O)OC)c1.O.O.[Li+].[OH-]>>COC[C@@H](C)Oc1cc(OCc2ccccc2)cc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](CN)CC1.O=C(NCc1ccc(-c2cc(C(=O)O)c3ccccc3n2)cc1)OCC1c2ccccc2-c2ccccc21>>CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](CNC(=O)c2cc(-c3ccc(CNC(=O)OCC4c5ccccc5-c5ccccc54)cc3)nc3ccccc23)CC1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)c1ccccc1S(=O)(=O)n1cc(CN(C)C(=O)OC(C)(C)C)cc1-c1ccccc1.Cl.[Na+].[OH-]>>CN(Cc1cc(-c2ccccc2)n(S(=O)(=O)c2ccccc2C(=O)O)c1)C(=O)OC(C)(C)C",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CCO)c1ccc(Nc2cc(-c3cccc(-c4ccccc4)c3)ncn2)cc1.ClCCl.O=S(Cl)Cl>>CCN(CCCl)c1ccc(Nc2cc(-c3cccc(-c4ccccc4)c3)ncn2)cc1",
        "output": "96"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(C(=O)O)cc2)C(=O)C1.CCOC(C)=O.Nc1ccc(Cl)c(-c2ccccn2)c1>>CC(C)(C)OC(=O)N1CCN(c2ccc(C(=O)Nc3ccc(Cl)c(-c4ccccn4)c3)cc2)C(=O)C1",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COCOCc1ccccc1C(C[N+](=O)[O-])c1ccccc1.[Ni]>>COCOCc1ccccc1C(CN)c1ccccc1",
        "output": "226"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NCC1CN(Cc2ccc(Cl)c(Cl)c2)CCO1.O=C(O)Cc1ccco1>>O=C(Cc1ccco1)NCC1CN(Cc2ccc(Cl)c(Cl)c2)CCO1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(C(=O)C2CCN(CC(=O)O)CC2)cc1.O=c1[nH]c(CNCC2CC2)nc2c1CCCC2>>COc1ccc(C(=O)C2CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)CCCC4)CC3CC3)CC2)cc1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "B.C1CCOC1.C1CCOC1.CCOCC.Cl.ClCCl.N#CCCN1CCC(O)(c2ccccc2)CC1.[Na+].[OH-]>>NCCCN1CCC(O)(c2ccccc2)CC1",
        "output": "246"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "N#C[C@@H]1C[C@@H]2C[C@@H]2N1.O=C(N[C@H](C(=O)O)C12CC3CC(CC(O)(C3)C1)C2)OCc1ccccc1>>N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](NC(=O)OCc1ccccc1)C12CC3CC(CC(O)(C3)C1)C2",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O.COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=S)Nc4ccccc4F)cc3)cc2C1=O.S=C=Nc1ccc(Cl)cc1>>COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=S)Nc4ccc(Cl)cc4)cc3)cc2C1=O",
        "output": "474"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#C[Si](C)(C)C.N#Cc1cc(I)ccc1F>>C[Si](C)(C)C#Cc1ccc(F)c(C#N)c1",
        "output": "826"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(N2CCOCC2)c1.Cl>>Nc1cccc(N2CCOCC2)c1",
        "output": "782"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCCCC.CO.COC(=O)c1nccc(-c2ccc(OC)c(C3C4=C(CC(C)(C)CC4=O)OC4=C3C(=O)CC(C)(C)C4)c2C)n1.ClCCl.[Na+].[OH-]>>COc1ccc(-c2ccnc(C(=O)O)n2)c(C)c1C1C2=C(CC(C)(C)CC2=O)OC2=C1C(=O)CC(C)(C)C2",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1nccs1.CC(C)(C)OC(=O)N1CCNCC1.CCO.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(c2nccs2)CC1",
        "output": "657"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.COCCl.Cl.O.O=C([O-])[O-].O=Cc1cc(Br)ccc1O.[K+].[K+]>>COCOc1ccc(Br)cc1C=O",
        "output": "375"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)N1c2ccc(N)cc2C(C)(c2ccccc2)CC1(C)C.CCN(C(C)C)C(C)C.O=C(Cl)c1ccc(-c2ccccc2)cc1>>CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C",
        "output": "11"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.COC(=O)COC(C)(C)C#Cc1cc(-c2ccc(Cl)cc2)ccc1C.O.[K+].[OH-]>>Cc1ccc(-c2ccc(Cl)cc2)cc1C#CC(C)(C)OCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "B.C1CCOC1.C1CCOC1.CCCCCCC(=O)NCCc1cccc(O[Si](C)(C)C(C)(C)C)c1>>CCCCCCCNCCc1cccc(O[Si](C)(C)C(C)(C)C)c1",
        "output": "112"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1coc(Cn2cc(Br)cn2)n1.Cl.N#N.[Na+].[OH-]>>O=C(O)c1coc(Cn2cc(Br)cn2)n1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.N[C@@H]1CCCC[C@H]1CN1CCCCC1.O=C(O)c1ccc(-n2cccn2)nc1>>O=C(N[C@@H]1CCCC[C@H]1CN1CCCCC1)c1ccc(-n2cccn2)nc1",
        "output": "674"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(N)c1nccs1.CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)c(F)c3)c2cc1OC.ClC(Cl)Cl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)NC(C)c4nccs4)c(F)c3)c2cc1OC",
        "output": "913"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cl.ClCCl.NCCc1ccc2c(c1)C(=O)c1ccccc1CO2.O>>CS(=O)(=O)NCCc1ccc2c(c1)C(=O)c1ccccc1CO2",
        "output": "493"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1noc(-c2c(F)cccc2C(=O)N2CC3CN(C(=O)OC(C)(C)C)CC3C2)n1.ClCCl.O=C(O)C(F)(F)F>>Cc1noc(-c2c(F)cccc2C(=O)N2CC3CNCC3C2)n1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CC(=O)c1cccc(-n2ccnn2)c1.CCCN(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1C(F)(F)F>>CCCN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-n3ccnn3)c2)cc1C(F)(F)F",
        "output": "929"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Cl.O=C(CCOCCc1ccc2sccc2c1)N1CC(O)C1.[BH4-].[Na+]>>OC1CN(CCCOCCc2ccc3sccc3c2)C1",
        "output": "112"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CNCCO.O=C(CBr)Nc1cn(CCCN2C(=O)c3ccccc3C2=O)cc1-c1ccc(Cl)cc1Cl>>CN(CCO)CC(=O)Nc1cn(CCCN2C(=O)c3ccccc3C2=O)cc1-c1ccc(Cl)cc1Cl",
        "output": "443"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOc1cc(C(CC(=O)O)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC(F)F.Cl.NO.O=C(n1ccnc1)n1ccnc1>>CCOc1cc(C(CC(=O)NO)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC(F)F",
        "output": "480"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCCN1CCCN(C2CCN(C(=O)[C@H](O)CS(=O)(=O)c3ccc4cc(Cl)ccc4c3)CC2)C1=O.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>O=C([C@H](O)CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)N1CCC(N2CCCN(CCO)C2=O)CC1",
        "output": "708"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cl.NCCNC(=O)Nc1ccc(O)c(F)c1.c1cc(OCC2CO2)ccc1OCCOC1CCCC1>>O=C(NCCNCC(O)COc1ccc(OCCOC2CCCC2)cc1)Nc1ccc(O)c(F)c1",
        "output": "16"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.COc1ccc(-c2cnc(N3CCOCC3)cc2N)cn1.Cc1ccc(-c2nc3cc(F)cc(F)c3c(Cl)c2C)nc1.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>COc1ccc(-c2cnc(N3CCOCC3)cc2Nc2c(C)c(-c3ccc(C)cn3)nc3cc(F)cc(F)c23)cn1",
        "output": "115"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN1CC(O)Cc2c(N)cccc21.O=C=Nc1ccc(Cl)c(C(F)(F)F)c1>>CN1CC(O)Cc2c(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cccc21",
        "output": "473"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.COC(=O)c1ccc2[nH]c(C(=O)O)cc2n1.Cl.Cl.ClCCl.NC1CCN(c2ccncc2)CC1.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>>COC(=O)c1ccc2[nH]c(C(=O)NC3CCN(c4ccncc4)CC3)cc2n1",
        "output": "137"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=Cc1ccc(F)cc1.Oc1cncc(C(F)(F)F)c1>>O=Cc1ccc(Oc2cncc(C(F)(F)F)c2)cc1",
        "output": "845"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.N#Cc1ccc(Cl)cc1F.O.O=C([O-])[O-].O=Cc1cccc(O)c1.[Cs+].[Cs+]>>N#Cc1ccc(Cl)cc1Oc1cccc(C=O)c1",
        "output": "564"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc2c(cc1Br)CCC2=O.Cc1ccccc1.O.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C1CCc2cc(Br)c(O)cc21",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.CC(C)=O.O=C([O-])[O-].O=Cc1ccc(OCCBr)cc1OCc1ccccc1Br.[I-].[K+].[K+].[Na+]>>O=Cc1ccc(OCCN2CCOCC2)cc1OCc1ccccc1Br",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1.Cc1nnc(CC2CCC(c3ncc(-c4ccc(N)cc4)s3)CC2)o1.O=C=Nc1ccc(F)cc1F>>Cc1nnc(CC2CCC(c3ncc(-c4ccc(NC(=O)Nc5ccc(F)cc5F)cc4)s3)CC2)o1",
        "output": "473"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)c1ccncc1.COC(=O)[C@@H](CO)NCc1ccccc1.ClCCl.O>>COC(=O)[C@@H](CO[Si](C)(C)C(C)(C)C)NCc1ccccc1",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@@H](CO[Si](C)(C)C(C)(C)C)Oc1cc(Oc2ccc(C(=O)N3CCC3)cc2)cc(C(=O)O)c1.Cc1cc(N)nn1C.F[P-](F)(F)(F)(F)F.O>>Cc1cc(NC(=O)c2cc(Oc3ccc(C(=O)N4CCC4)cc3)cc(O[C@@H](C)CO[Si](C)(C)C(C)(C)C)c2)nn1C",
        "output": "917"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.Cl.ClCCl.O.O=C1CCNCC1.O=S(=O)(Cl)c1ccc(OC(F)(F)F)cc1>>O=C1CCN(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)CC1",
        "output": "99"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.F[P-](F)(F)(F)(F)F.NC1CC1.O=C(O)c1ccnc(Cl)n1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>O=C(NC1CC1)c1ccnc(Cl)n1",
        "output": "137"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.CCOCC.[N-]=[N+]=Nc1cccc2cccc(N)c12.c1ccncc1>>CC(=O)Nc1cccc2cccc(N=[N+]=[N-])c12",
        "output": "9"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1cc(=O)cc(-c2ccc([N+](=O)[O-])cc2)o1.CN(C)C=O.O=C([O-])[O-].[C].[K+].[K+].[Pd]>>CCOC(=O)c1cc(=O)cc(-c2ccc(N)cc2)o1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)Cc1c[nH]c2ccc(F)cc12.O=C(Cl)c1ccccc1>>CC(C)(C)OC(=O)Cc1cn(C(=O)c2ccccc2)c2ccc(F)cc12",
        "output": "232"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOCC.COc1ccc(Br)c2oc(N3CCCCC3)nc12>>Oc1ccc(Br)c2oc(N3CCCCC3)nc12",
        "output": "424"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cc1cc(N)c(CN)c(O)n1.Cl.ClCCl.O.O=C(O)c1ccc(Oc2ccccc2)cc1.On1nnc2ccccc21>>Cc1cc(N)c(CNC(=O)c2ccc(Oc3ccccc3)cc2)c(O)n1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCN1CCN(c2nc(C)c(C(=O)OCC)s2)C1=O.CCOC(=O)c1sc(N2CCN(c3ccccc3)C2=O)nc1C>>CCCCN1CCN(c2nc(C)c(C(=O)O)s2)C1=O",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)C(C)(C)c1ccc(Cl)c([N+](=O)[O-])c1.[K+].[OH-]>>CC(C)(C(=O)O)c1ccc(Cl)c([N+](=O)[O-])c1",
        "output": "203"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1ccc(N)cc1C.COc1cn(C(C(=O)O)C(C)C)c(=O)cc1-c1cc(Cl)ccc1C#N>>COC(=O)c1ccc(NC(=O)C(C(C)C)n2cc(OC)c(-c3cc(Cl)ccc3C#N)cc2=O)cc1C",
        "output": "710"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=Cc1cc(F)c(F)c(F)c1.Oc1cncc(Cl)c1>>O=Cc1cc(F)c(Oc2cncc(Cl)c2)c(F)c1",
        "output": "845"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=[N+]=[N-].Cc1nc(CC(=O)O)no1>>COC(=O)Cc1noc(C)n1",
        "output": "60"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.CO.COc1ccc(-c2sc3ccccc3c2C(=O)c2ccc(OC)c(C)c2)cc1.ClCCl>>Cc1cc(C(=O)c2c(-c3ccc(O)cc3)sc3ccccc23)ccc1O",
        "output": "20"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.COc1cccc(CC(O)(C(=O)Nc2ccc(C#N)c(C(F)(F)F)c2)C2CCCCC2)c1.ClCCl>>N#Cc1ccc(NC(=O)C(O)(Cc2cccc(O)c2)C2CCCCC2)cc1C(F)(F)F",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COc1cc(N)c([N+](=O)[O-])cc1F.[Pd]>>COc1cc(N)c(N)cc1F",
        "output": "202"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc2ccnc(Cl)c2n1.Nc1cccc(Cl)c1>>Cc1ccc2ccnc(Nc3cccc(Cl)c3)c2n1",
        "output": "780"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)CCc1ccc(OC)nc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1ccc(CCCO)cn1",
        "output": "343"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1ccccc1SC1=C(O)CC(CCC(C)C)(c2ccccc2)OC1=O.[Na+].[OH-]>>CC(C)CCC1(c2ccccc2)CC(O)=C(Sc2ccccc2C(=O)O)C(=O)O1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1cnn(-c2cccc(Cl)c2F)c1N.CO.[Na+].[OH-]>>Nc1c(C(=O)O)cnn1-c1cccc(Cl)c1F",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCCCCCC(=O)O.CCCCCCCCCCCC(O)CC(=O)OC(C)(C)C>>CCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC(C)(C)C",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CC1(C)O[C@@H]2[C@H](N=[N+]=[N-])C(=O)O[C@H]([C@@H](O)CO)[C@@H]2O1.CCN(CC)CC.CN(C)c1ccncc1.ClCCl>>CC1(C)O[C@@H]2[C@H](N=[N+]=[N-])C(=O)O[C@H]([C@@H](O)CO[Si](C)(C)C(C)(C)C)[C@@H]2O1",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CCc1cnc(C(C)(C)C#N)c(Cl)c1.O.[Na+].[OH-]>>CC(C)(C#N)c1ncc(CCC(=O)O)cc1Cl",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC1CC(CO)(NC(=O)C2C3C(CN2C(=O)C(NC(=O)OC(C)(C)C)C(C)(C)C)C3(C)C)C1.ClCCl>>CC1CC(C=O)(NC(=O)C2C3C(CN2C(=O)C(NC(=O)OC(C)(C)C)C(C)(C)C)C3(C)C)C1",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCCc1ccccc1.CC#N.COc1ccc(Br)c(CC2CCNCC2)c1.Cl.O=C([O-])[O-].[I-].[K+].[K+].[K+].[Na+].[OH-]>>COc1ccc(Br)c(CC2CCN(CCc3ccccc3)CC2)c1",
        "output": "73"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1nn(Cc2ccccc2)c2ncccc12.[Na+].[OH-]>>O=C(O)c1nn(Cc2ccccc2)c2ncccc12",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CSc1cccc(N=C=O)c1.NCC1CN(Cc2ccc(Cl)c(Cl)c2)CCO1>>CSc1cccc(NC(=O)NCC2CN(Cc3ccc(Cl)c(Cl)c3)CCO2)c1",
        "output": "35"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)n1nc(-c2ccc(O)cc2)c(C#N)c1N.OCCN1CCOCC1.Oc1ccc(OCc2ccccc2)cc1>>c1ccc(COc2ccc(OCCN3CCOCC3)cc2)cc1",
        "output": "550"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.Cl.ClCCl.NCCc1ccccn1.O.O=C(O)C1CCN(C(=O)c2cc3ccccc3n2Cc2ccc(Cl)cc2)CC1.On1nnc2ccccc21>>O=C(NCCc1ccccn1)C1CCN(C(=O)c2cc3ccccc3n2Cc2ccc(Cl)cc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCc1ccccc1.CC(C)=O.Cc1cc(O)c(F)cc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>Cc1cc(OCc2ccccc2)c(F)cc1[N+](=O)[O-]",
        "output": "127"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(N)(c1cccc(Br)c1)c1cc[nH]n1.CCN(C(C)C)C(C)C.ClCCl.O=C(Cl)CCl.[Cl-].[NH4+]>>CC(NC(=O)CCl)(c1cccc(Br)c1)c1cc[nH]n1",
        "output": "206"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CCS(=O)(=O)c1ccc(NC(C)=O)cc1.CCO.Cl>>CCN(CC)CCS(=O)(=O)c1ccc(N)cc1",
        "output": "66"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "OCC1CCOC1.Oc1nc(Cl)nc2cnccc12>>Oc1nc(OCC2CCOC2)nc2cnccc12",
        "output": "37"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCC(c1ccccc1)N1C(=O)c2ccccc2C1=O.CO.NN.O>>CC(C)(C)OC(=O)NCC(N)c1ccccc1",
        "output": "418"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCCCCCC(=O)Cl.CCN(CC)CC.OCC1CCCCN1>>CCCCCCCCCCCC(=O)OCC1CCCCN1",
        "output": "126"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCCCCCCCCCCC(O)(N[C@@H](CS)C(=O)OC(C)(C)C)C(=O)CCCCCCCCCCCCCC.O=C(O)C(F)(F)F>>CCCCCCCCCCCCCCCCC(O)(N[C@@H](CS)C(=O)O)C(=O)CCCCCCCCCCCCCC",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)C(C(=O)O)c1cc2cc(F)ccc2s1.CN(C)C=O.CN(C)c1ccncc1.ClCCl.OCc1[nH]ccc1Cc1ccccc1>>CC(C)C(C(=O)OCc1[nH]ccc1Cc1ccccc1)c1cc2cc(F)ccc2s1",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)O)c3ccc(C)cc3n2)CC1.CN(C)C=O.Cl.ClCCCl.O.O=C(NC1CC1)[C@@H]1CCCN1.Oc1c(F)c(F)c(F)c(F)c1F>>CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NC3CC3)c3ccc(C)cc3n2)CC1",
        "output": "297"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)c1c(N)nn2cccnc12.O=C(Cl)CC12CC3CC(CC(C3)C1)C2>>CC(C)(C)c1c(NC(=O)CC23CC4CC(CC(C4)C2)C3)nn2cccnc12",
        "output": "527"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(Cl)Cl.CN(C)C=O.ClCCCl.ClOCl.[Na+].[OH-].[P+5].c1ccn(-c2nccs2)c1>>O=Cc1cccn1-c1nccs1",
        "output": "641"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cc2c(cn1)[nH]c1cccc(CO)c12.ClCCl.[Mn+4].[O-2].[O-2]>>CCOC(=O)c1cc2c(cn1)[nH]c1cccc(C=O)c12",
        "output": "179"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.Cl.ClC(Cl)(Cl)Cl.ClCCl.O=C(O)C1CCc2ccccc21>>O=C(O)C1CCc2ccc(Br)cc21",
        "output": "98"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)c1cnc2ccc(OC)cc2c1N.[Na+].[OH-]>>COc1ccc2ncc(C(=O)O)c(N)c2c1",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.CCOC(C)=O.C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C(CC#N)C(F)(F)F)c3)ncnc21.Cl.O.O=C([O-])O.[NH4+].[Na+].[OH-]>>N#CCC(n1cc(-c2ncnc3[nH]ccc23)cn1)C(F)(F)F",
        "output": "897"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCO.CCN(CC)CC.CCOCC.O=C(O)CC1CC1.O=S(Cl)Cl>>CCCCOC(=O)CC1CC1",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(Oc1ccccc1C(C)C)C(=O)O.C[C@H]1C=CC2=C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O)[C@@H]2[C@H]1CC[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CC(=O)O1>>CC(Oc1ccccc1C(C)C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O[Si](C)(C)C(C)(C)C)CC(=O)O3)[C@H]21",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CN(C)CCN(C)c1nc2ccc([N+](=O)[O-])cc2s1.[H][H].[Pd]>>CN(C)CCN(C)c1nc2ccc(N)cc2s1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1NCCn2c(Br)ccc21.O=C(O)c1cc2ncc(Cl)cn2n1>>CC1c2ccc(Br)n2CCN1C(=O)c1cc2ncc(Cl)cn2n1",
        "output": "663"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1cc2ccc(C(F)C(N)=O)cc2s1.CO.Cl.[Li+].[OH-]>>NC(=O)C(F)c1ccc2cc(C(=O)O)sc2c1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1/C=C/c1ccc(CN(Cc2ccc([N+](=O)[O-])cc2)c2ccccc2)cc1.CCO.CO.Cl[Bi](Cl)Cl.[BH4-].[Na+]>>CC(C)(C)OC(=O)N1CCC[C@H]1/C=C/c1ccc(CN(Cc2ccc(N)cc2)c2ccccc2)cc1",
        "output": "507"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CSCCN1C(=O)C(N)Cc2ccccc21.ClCCl.O=C(O)c1cc2cc(Cl)sc2[nH]1.On1nnc2ccccc21>>CSCCN1C(=O)C(NC(=O)c2cc3cc(Cl)sc3[nH]2)Cc2ccccc21",
        "output": "738"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)c1ccc(C)c(OC2CCNCC2)c1.Cl.Cl.O.O=C(O)CNC(=O)c1cc(-c2ccccc2)[nH]n1.On1nnc2ccccc21>>COC(=O)c1ccc(C)c(OC2CCN(C(=O)CNC(=O)c3cc(-c4ccccc4)[nH]n3)CC2)c1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCn1cnc(-c2cc3nccc(Cl)c3s2)c1C.ClCCl.O=C([O-])[O-].O=[N+]([O-])c1ccc(O)c(F)c1.[K+].[K+].c1ccc(Oc2ccccc2)cc1>>CCn1cnc(-c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)c1C",
        "output": "936"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C([O-])O.OCc1cn(-c2cccc(Cl)c2)nn1.[Na+]>>CS(=O)(=O)OCc1cn(-c2cccc(Cl)c2)nn1",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CN.Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1Cc1cnc(S(C)(=O)=O)nc1.O>>CNc1ncc(Cn2c(C)cc(OCc3ccc(F)cc3F)c(Br)c2=O)cn1",
        "output": "629"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(Cc1cccc(-c2cccn3nc(Cl)nc23)c1)S(C)(=O)=O.CN1CCN(c2ccc(N)cc2)CC1.c1ccc(P(C2CCCCC2)C2CCCCC2)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c1>>CN1CCN(c2ccc(Nc3nc4c(-c5cccc(CN(C)S(C)(=O)=O)c5)cccn4n3)cc2)CC1",
        "output": "990"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(CC)C1CN(C(=O)OC(C)(C)C)CC(OCc2ccc3ccccc3c2)C1c1ccc(Cl)cc1.ClCCl.[Br-].[Br-].[Zn+2]>>CCC(CC)C1CNCC(OCc2ccc3ccccc3c2)C1c1ccc(Cl)cc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)/C=C/c1cnn2ccc(N3CCCC3c3cncc(F)c3)nc12>>CCNC(=O)/C=C/c1cnn2ccc(N3CCCC3c3cncc(F)c3)nc12",
        "output": "767"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.Nc1cc(OC2CCCCC2)c(Cl)cc1F.O.O=C1OC(=O)C2=C1CCCC2>>O=C1C2=C(CCCC2)C(=O)N1c1cc(OC2CCCCC2)c(Cl)cc1F",
        "output": "410"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)O[K].CC1CCC=C[C@@H]2C[C@@]2(C(=O)NS(=O)(=O)C2(C)CC2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)OC(C)(C)C)[C@H](C)C1.CS(C)=O.Clc1nccc2c3c(ccc12)CCO3>>CC1CCC=C[C@@H]2C[C@@]2(C(=O)NS(=O)(=O)C2(C)CC2)NC(=O)[C@@H]2C[C@@H](Oc3nccc4c5c(ccc34)CCO5)CN2C(=O)[C@@H](NC(=O)OC(C)(C)C)[C@H](C)C1",
        "output": "433"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Br.Brc1cccc2c1CCNC2.C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC>>CC(C)(C)OC(=O)N1CCc2c(Br)cccc2C1",
        "output": "867"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOP(=O)(C#N)OCC.COc1cc2c(C(=O)O)cnc(CNC(=O)OC(C)(C)C)c2cc1OC.c1ccc2c(c1)CCNC2>>COc1cc2c(C(=O)N3CCc4ccccc4C3)cnc(CNC(=O)OC(C)(C)C)c2cc1OC",
        "output": "893"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1CCC(CCO)NC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cc(C(=O)O)cc2nc(NCc3cc(Cl)ccn3)oc12.F[P-](F)(F)(F)(F)F.O>>COc1cc(C(=O)N2CC(C)CCC2CCO)cc2nc(NCc3cc(Cl)ccn3)oc12",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2.CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(C=O)c3)c2)n1.CS(C)=O>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4C[C@@H]5C[C@H]4CN5)c3)c2)n1",
        "output": "935"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)O.CCOC(C)=O.CNc1cc(OC)ccc1[N+](=O)[O-].O=C([O-])O.[BH4-].[Na+].[Na+]>>CNc1cc(OC)ccc1N",
        "output": "202"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1cn[nH]c1.C1COCCO1.CCOC(C)=O.I[Cu]I.Ic1ccccc1.N#N.N[C@@H]1CCCC[C@H]1N.O=C([O-])[O-].[K+].[K+]>>Brc1cnn(-c2ccccc2)c1",
        "output": "901"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCBr.CN(C)C=O.COc1ccccc1CC(=O)c1c[nH]c2ccccc12.O.[H-].[Na+]>>CCCCCn1cc(C(=O)Cc2ccccc2OC)c2ccccc21",
        "output": "470"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CCN(CCN)CC1.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c(Cl)c1.[K+].[K+]>>CC1CCN(CCNc2ccc([N+](=O)[O-])cc2Cl)CC1",
        "output": "572"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOP(=O)(OCC)c1cc(Cc2ccc(CC)cc2)c(OC)cc1OC.CO.C[Si](C)(C)Br.ClCCl>>CCc1ccc(Cc2cc(P(=O)(O)O)c(OC)cc2OC)cc1",
        "output": "535"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC(=O)NCc1ccc(/N=N/c2ccc(C(=O)OC)cc2)cc1.CO.ClC(Cl)Cl.NCCN.O>>CCCC(=O)NCc1ccc(/N=N/c2ccc(C(=O)NCCN)cc2)cc1",
        "output": "338"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCNC.COc1ccc2[nH]c3c(c2c1)CC1(C)C(=O)N(CCBr)C(=O)N1C3c1ccccc1>>CCN(C)CCN1C(=O)N2C(c3ccccc3)c3[nH]c4ccc(OC)cc4c3CC2(C)C1=O",
        "output": "73"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)CCCBr.NC1CCCCC1>>CCOC(=O)CCCNC1CCCCC1",
        "output": "147"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCn1c(C)c(-c2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(=O)OC)cc2)c(=O)n(CC)c1=O.[Na+].[OH-]>>CCn1c(C)c(-c2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(=O)O)cc2)c(=O)n(CC)c1=O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)NC(=O)COc1cccc(B2OC(C)(C)C(C)(C)O2)c1.CN(c1ccc2c(cnn2C(=O)OC(C)(C)C)c1)c1ccnc(Cl)n1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>CC(C)NC(=O)COc1cccc(-c2nccc(N(C)c3ccc4c(cnn4C(=O)OC(C)(C)C)c3)n2)c1",
        "output": "974"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNC1.O=Cc1ccc2cc(-c3csc(-c4ccncc4)n3)c(=O)[nH]c2c1>>O=c1[nH]c2cc(CN3CCCC3)ccc2cc1-c1csc(-c2ccncc2)n1",
        "output": "567"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(CNC[C@@H](O)[C@H](Cc2ccccc2)NC(=O)c2cccc(C(=O)N(C)Cc3nc(C)cs3)c2)cc(N(C)S(C)(=O)=O)c1.[Na+].[OH-]>>Cc1csc(CN(C)C(=O)c2cccc(C(=O)N[C@@H](Cc3ccccc3)[C@H](O)CNCc3cc(C(=O)O)cc(N(C)S(C)(=O)=O)c3)c2)n1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CN1CCOCC1.Cn1c(C(=O)O)cc2ccccc21.[NH4+].[OH-]>>Cn1c(C(N)=O)cc2ccccc21",
        "output": "136"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CS(C)=O.Cn1ncc2cc(Br)ccc21.[K+]>>Cn1ncc2cc(B3OC(C)(C)C(C)(C)O3)ccc21",
        "output": "942"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CC[C@@H](N)CC1.Cc1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)O)c(C)n(COCC[Si](C)(C)C)c23)c1>>Cc1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)N[C@H]4CC[C@@H](NC(=O)OC(C)(C)C)CC4)c(C)n(COCC[Si](C)(C)C)c23)c1",
        "output": "737"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1ccn(CCO)c(=O)n1.O=S(Cl)Cl>>Nc1ccn(CCCl)c(=O)n1",
        "output": "96"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N(CCC(=O)[O-])C1CCC1.CCCCCCC.CCOC(C)=O>>CC(C)(C)OC(=O)N(CCCO)C1CCC1",
        "output": "231"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.O=C1CCCCC(Cc2ccc(Cl)cc2)N1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Clc1ccc(CC2CCCCCN2)cc1",
        "output": "112"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(-n2cnn(Cc3ccc(C(F)(F)F)cc3)c2=O)sc1C(=O)O.Cc1cc(-n2cnn(Cc3ccc(F)cc3)c2=O)sc1C(=O)O.NCc1cccnc1>>Cc1cc(-n2cnn(Cc3ccc(C(F)(F)F)cc3)c2=O)sc1C(=O)NCc1cccnc1",
        "output": "736"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC(C)=O.CCOCC.ClCCBr.O=C([O-])[O-].Oc1c(Br)cc(F)cc1Br.[K+].[K+]>>Fc1cc(Br)c(OCCCl)c(Br)c1",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)COCCN1.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(C(C)C)C(C)C.COc1cc2c(cc1SCC(C)C)-c1c(c(C(=O)O)nn1-c1ccsc1)CO2.ClCCl>>COc1cc2c(cc1SCC(C)C)-c1c(c(C(=O)N3CCOCC3(C)C)nn1-c1ccsc1)CO2",
        "output": "663"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)O.CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.COc1ccccc1Br.Cc1ccccc1.Nc1ccc2c(c1)OCc1cc([N+](=O)[O-])ccc1C2=O.[K+].[Pd+2]>>COc1ccccc1Nc1ccc2c(c1)OCc1cc([N+](=O)[O-])ccc1C2=O",
        "output": "405"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)O.CCN(C(C)C)C(C)C.CCOC(=O)c1cncc(-c2cnn3cc(-c4ccc(OC)cc4)cnc23)c1.CN.CN(C)C=O.COCCOC.Cl.Cl.ClCCl.O=C(Cl)C(=O)Cl.[Na+].[OH-]>>CNC(=O)c1cncc(-c2cnn3cc(-c4ccc(OC)cc4)cnc23)c1",
        "output": "498"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CCOC(=O)N1CCc2sccc2C(C)C1.ClC(Cl)Cl.O=C1CCC(=O)N1Br>>CCOC(=O)N1CCc2sc(Br)cc2C(C)C1",
        "output": "807"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C1(CN)CCS(=O)C1.O=C(O)c1nn(-c2ccc(F)cc2F)c2c1C[C@@H]1C[C@H]21>>CN(C)C1(CNC(=O)c2nn(-c3ccc(F)cc3F)c3c2C[C@@H]2C[C@H]32)CCS(=O)C1",
        "output": "816"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Nc1cccc(CCC(=O)O)c1.O=C=Nc1cccc(Cl)c1Cl>>O=C(O)CCc1cccc(NC(=O)Nc2cccc(Cl)c2Cl)c1",
        "output": "473"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc([N+](=O)[O-])ccc1N.O=C(O)Cc1ccccc1Br>>COc1cc([N+](=O)[O-])ccc1Nc1ccccc1CC(=O)O",
        "output": "405"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CC1.CN(C)C=O.O.O=c1[nH]c2cc(Cl)ccc2c2ccncc12>>O=c1c2cnccc2c2ccc(Cl)cc2n1CC1CC1",
        "output": "470"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.O=C(Cl)OCc1ccccc1.OCCNCCC(c1ccccc1)c1ccccc1.c1ccncc1>>O=C(OCc1ccccc1)N(CCO)CCC(c1ccccc1)c1ccccc1",
        "output": "427"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc2c(N)ccc(O)c2n1.Cl.O.O=N[O-].[N-]=[N+]=[N-].[Na+].[Na+]>>Cc1ccc2c(N=[N+]=[N-])ccc(O)c2n1",
        "output": "189"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCOC(OCCC)P(=O)(CCCN)OCC.CCO.O.O.[Li+].[OH-]>>CCCOC(OCCC)P(=O)(O)CCCN",
        "output": "618"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#CCCC(=O)OC.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.O=[N+]([O-])c1cccc(Br)c1F.[Cu]I.[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)CCC#Cc1cccc([N+](=O)[O-])c1F",
        "output": "659"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCN(CC)c1ccc(NC(=O)c2cccc(CCCOCCOCCOCCOCCN)c2)c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1.ClCCl.O=C(O)c1ccc(S(=O)(=O)Cl)cc1>>CCN(CC)c1ccc(NC(=O)c2cccc(CCCOCCOCCOCCOCCNS(=O)(=O)c3ccc(C(=O)O)cc3)c2)c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1",
        "output": "43"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CBr.CN(C)C=O.NC1(C(=O)O)CC2CCC1C2.NC1(CO)CC2CCC1C2.NO>>CC(C)CNC1(CO)CC2CCC1C2",
        "output": "147"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCc1ccc([C@H]2C[C@@H](C(F)(F)F)n3ncc(C(=O)O)c3N2)cc1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1ccc(CN)o1.F[P-](F)(F)(F)(F)F>>CCc1ccc([C@H]2C[C@@H](C(F)(F)F)n3ncc(C(=O)NCc4ccc(C)o4)c3N2)cc1",
        "output": "621"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Br.COc1ccc(N)c2c1CCC2=O.O=C([O-])O.[Na+]>>Nc1ccc(O)c2c1C(=O)CC2",
        "output": "402"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)[O-].COCCOCOc1ccc(C=O)cc1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-].[K+]>>C=Cc1ccc(OCOCCOC)cc1",
        "output": "649"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.O=C(c1ccc(Nc2ccnc3cc(C(F)(F)F)ccc23)cc1)N1CCNCC1.O=S(=O)(Cl)c1cccc(Br)c1>>O=C(c1ccc(Nc2ccnc3cc(C(F)(F)F)ccc23)cc1)N1CCN(S(=O)(=O)c2cccc(Br)c2)CC1",
        "output": "99"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.COC(=O)C(Cc1ccccc1)Cc1cc2cc(O)ccc2[nH]1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.OCCCNc1ccccn1>>O=C(O)C(Cc1ccccc1)Cc1cc2cc(OCCCNc3ccccn3)ccc2[nH]1",
        "output": "928"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCC.CCOC(C)=O.COC(Cl)Cl.COc1ccc(F)c(C)c1.ClCCl.Cl[Ti](Cl)(Cl)Cl>>COc1cc(C)c(F)cc1C=O",
        "output": "591"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(=O)N[C@@H]1CC[C@@H](N)CC1.CCN(C(C)C)C(C)C.Cl.O=[N+]([O-])c1ccc(CO)cc1F>>CC(=O)N[C@@H]1CC[C@@H](Nc2cc(CO)ccc2[N+](=O)[O-])CC1",
        "output": "572"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CBr.CN(C)C=O.COc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)COc1ccc(OC)cc1",
        "output": "123"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)[C@@H](N)Cc1ccc(O)c(C(C)(C)C)c1.N>>CC(C)(C)c1cc(C[C@H](N)C(N)=O)ccc1O",
        "output": "432"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.Nc1ccc(F)c(F)c1F>>CC(=O)Nc1ccc(F)c(F)c1F",
        "output": "6"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)N=C=NC(C)C.CCN(C(C)C)C(C)C.CN(C)C=O.CNCCN(C)[C@H]1COc2ccccc2-c2c(C3CCCCC3)c3ccc(C(=O)OC)cc3n2C1.NS(=O)(=O)CCCC(=O)O.On1nnc2ccccc21>>COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)C[C@@H](N(C)CCN(C)C(=O)CCCS(N)(=O)=O)COc1ccccc1-3",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(Cl)Cl.CN(C)C=O.ClCCl.Clc1ccccc1Cl.O=C(Cl)C(=O)Cl.O=C(O)CCCn1ccnc1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(CCCn1ccnc1)c1ccc(Cl)c(Cl)c1",
        "output": "435"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CNC.OC1(CC2CO2)c2ccccc2CCc2ccccc21>>CN(C)CC(O)CC1(O)c2ccccc2CCc2ccccc21",
        "output": "76"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CN(c1ccncc1)c1ccc(CN(C(=O)OC(C)(C)C)C2CCN(Cc3ccccc3)CC2)cc1.Cl.ClCCl.[Na+].[OH-]>>CN(c1ccncc1)c1ccc(CNC2CCN(Cc3ccccc3)CC2)cc1",
        "output": "887"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.C1CCOC1.CC(=O)OCC(=O)N1CCc2cc(-c3ccc(CCO[Si](C)(C)C(C)(C)C)cc3)ccc2C1.O=C([O-])O.[Na+]>>CC(=O)OCC(=O)N1CCc2cc(-c3ccc(CCO)cc3)ccc2C1",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1cnc2nc(COc3ccccn3)cn2c1.O=Cc1ccc(B(O)O)c(C(F)(F)F)c1>>O=Cc1ccc(-c2cnc3nc(COc4ccccn4)cn3c2)c(C(F)(F)F)c1",
        "output": "871"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.Cc1ccc(-c2nc3cccnc3n2CC(=O)O)s1.N.O=C(n1ccnc1)n1ccnc1>>Cc1ccc(-c2nc3cccnc3n2CC(N)=O)s1",
        "output": "313"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)Cl.N#Cc1c(C(F)(F)F)nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1N.c1ccncc1>>CCOC(=O)Nc1c(C#N)c(C(F)(F)F)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl",
        "output": "700"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCN1CC(c2ccc(N)cc2)C1.ClCCl.ClCCl.O=S(=O)(Cl)c1ccc(-c2cnco2)cc1.c1ccncc1>>CCCN1CC(c2ccc(NS(=O)(=O)c3ccc(-c4cnco4)cc3)cc2)C1",
        "output": "68"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1cccn2cc(CCl)nc12.Cl.O=C([O-])O.[Na+]>>O=C(O)c1cccn2cc(CCl)nc12",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCc1ccccc1.CC(C)[C@@H](NC(=O)OC(C)(C)C)c1nc2cc(Cl)ccc2c(=O)[nH]1.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CC(C)[C@@H](NC(=O)OC(C)(C)C)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1",
        "output": "389"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCC/C=C/C(=O)O.CN(C)CCN1CCCNCC1>>CCCCCCC/C=C/C(=O)N1CCCN(CCN(C)C)CC1",
        "output": "870"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCC(F)(F)C(F)c1cccc([N+](=O)[O-])c1.CO.[C].[Pd]>>CC(C)(C)OC(=O)NCC(F)(F)C(F)c1cccc(N)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)OCc1cc(N2CCOCC2)ccc1[N+](=O)[O-].CO.[Ni]>>CC(C)(C)[Si](C)(C)OCc1cc(N2CCOCC2)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cl.Nc1ccc(C(=O)O)cc1.O=N[O-].[K+].[Na+].[OH-]>>O=C(O)c1ccccc1",
        "output": "324"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.COCOc1ccc(C=CC(=O)c2c(OCOC)cc(OCOC)c(CC=C(C)C)c2O)cc1.O=C([O-])O.[Na+].c1ccncc1>>COCOc1ccc(C=CC(=O)c2c(OCOC)cc(OCOC)c(CC=C(C)C)c2OC(C)=O)cc1",
        "output": "46"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=C1CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@]12C.CCO.COS(=O)(=O)OC.O.O=C([O-])[O-].[K+].[K+]>>C=C1CC[C@H]2[C@@H]3CCc4cc(OC)ccc4[C@H]3CC[C@]12C",
        "output": "317"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.COc1ccc(C)cc1N.O.O=C1CCC(=O)N1Br.[Cl-].[Na+]>>COc1cc(Br)c(C)cc1N",
        "output": "4"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(CN)c2ccccc2Cl)CC1.O=C1OC(=O)c2ccccc21>>CC(C)(C)OC(=O)N1CCN(C(CN2C(=O)c3ccccc3C2=O)c2ccccc2Cl)CC1",
        "output": "341"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cl.O=C([O-])O.O=[N+]([O-])c1cccc(/C=C/c2ccccc2)c1.[Fe].[Na+]>>Nc1cccc(/C=C/c2ccccc2)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccc(OCc5ccccc5)cc4)nc4n3-c3cccnc3Nc3ccccc3-4)cc2)CCC1.CO.[Pd]>>CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccc(O)cc4)nc4n3-c3cccnc3Nc3ccccc3-4)cc2)CCC1",
        "output": "23"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.NCC1CC1.O=C(O)c1cc(-c2ccc(F)cc2)on1.O=P(Cl)(Cl)Cl.c1ccncc1>>O=C(NCC1CC1)c1cc(-c2ccc(F)cc2)on1",
        "output": "696"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)OC(=O)N1CCC(OCc2noc(-c3cc4c(CO)nccc4o3)n2)CC1.CO.ClCCl>>CC(C)(C)OC(=O)N1CCC(OCc2noc(-c3cc4c(C=O)nccc4o3)n2)CC1",
        "output": "263"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Nc1ccc2c(c1)CC(=O)N2.CCN(CC)CCN1CCc2[nH]c(C=O)c(C)c2C1=O>>CCN(CC)CCN1CCc2[nH]c(C=C3C(=O)Nc4ccc(NC(C)=O)cc43)c(C)c2C1=O",
        "output": "440"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N(C)C.CS(=O)(=O)c1nc(N2CCOCC2)cc(-n2c(C(F)F)nc3ccccc32)n1.N[C@H]1CC[C@H](N)CC1.O.O=C([O-])[O-].[K+].[K+]>>N[C@@H]1CC[C@@H](Nc2nc(N3CCOCC3)cc(-n3c(C(F)F)nc4ccccc43)n2)CC1",
        "output": "629"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C=O.COC(=O)CCCCCCC(=O)Cl.Nc1ccccc1NC1CC1>>COC(=O)CCCCCCC(=O)Nc1ccccc1NC1CC1",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COc1cc2c(N=C(NCCN(C)C)Nc3c(C)cccc3C)ncnc2cc1OCC1COCCN1Cc1ccccc1.ClCCl.O=C(O)C(F)(F)F.[H][H].[Pd]>>COc1cc2c(N=C(NCCN(C)C)Nc3c(C)cccc3C)ncnc2cc1OCC1COCCN1",
        "output": "84"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CNC[C@@H]1N1CCCCC1=O.CC(C)(C)P(c1ccccc1-c1ccccc1)C(C)(C)C.CC(C)(C)[O-].CC(C)c1noc(N2CCC([C@H](C)CCOc3ccc(Br)cn3)CC2)n1.CCOC(C)=O.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CC(C)c1noc(N2CCC([C@H](C)CCOc3ccc(N4C[C@H](NC(=O)OC(C)(C)C)[C@@H](N5CCCCC5=O)C4)cn3)CC2)n1",
        "output": "597"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cl.ClCCl.Cn1cc2ccc(Nc3ncc(Cl)c(NC4CCN(C(=O)OC(C)(C)C)CC4)n3)cc2n1>>Cn1cc2ccc(Nc3ncc(Cl)c(NC4CCNCC4)n3)cc2n1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCc1nc2c(N)nc3ccccc3c2n1CCCN.CN1CCCC1=O.O.O=C([O-])[O-].S=C=Nc1ccccc1.[K+].[K+]>>CCCCc1nc2c(N)nc3ccccc3c2n1CCCNC(=S)Nc1ccccc1",
        "output": "113"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC[C@H](CCN1CCC2(CC2)[C@H](O)C1)N1C[C@@H](C)NCCC1=O.Cl.Cl.O=C=Nc1cccc(Cl)c1>>COC[C@H](CCN1CCC2(CC2)[C@H](O)C1)N1C[C@@H](C)N(C(=O)Nc2cccc(Cl)c2)CCC1=O",
        "output": "323"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)CCc1cn(Cc2ccc(Cl)cc2Cl)nc1OCC.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>CCOc1nn(Cc2ccc(Cl)cc2Cl)cc1CCCO",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(N)c(Cl)cc1C=O.O=C(Cl)CCCl>>COc1cc(NC(=O)CCCl)c(Cl)cc1C=O",
        "output": "9"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O.COC(=O)[C@H]1C[C@@H](O)CN1C(=O)OC(C)(C)C.O.[BH4-].[Li+]>>CC(C)(C)OC(=O)N1C[C@H](O)C[C@@H]1CO",
        "output": "430"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(N)c(N)c1.COc1ccc2nc(-c3ccc([N+](=O)[O-])cc3)[nH]c2c1.O=C(O)c1ccc([N+](=O)[O-])cc1.O=P(Cl)(Cl)Cl>>COc1ccc2nc(-c3ccc(N)cc3)[nH]c2c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.COc1ncc(CC(=O)O)cc1-c1cc2c(n1C(C)C)C(c1ccc(C#N)cc1)N(c1cccc(Cl)c1F)C2=O.Cl.F[P-](F)(F)(F)(F)F>>CNC(=O)Cc1cnc(OC)c(-c2cc3c(n2C(C)C)C(c2ccc(C#N)cc2)N(c2cccc(Cl)c2F)C3=O)c1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCN(CCCCC(O)c3ccccc3)CC2)c1.COc1ccc(O)cc1>>COc1ccc(OC(CCCCN2CCC(c3cccc(NC(=O)C(C)C)c3)CC2)c2ccccc2)cc1",
        "output": "342"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.C[Si](C)(C)C#Cc1ccc(C=O)cc1.O=C([O-])[O-].[Br-].[K+].[K+].[K+]>>C#Cc1ccc(C=O)cc1",
        "output": "337"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc2[nH]c3c(c2c1)CC1(C)C(=O)N(CCBr)C(=O)N1C3c1cccc(O)c1.NC1CC1>>COc1ccc2[nH]c3c(c2c1)CC1(C)C(=O)N(CCNC2CC2)C(=O)N1C3c1cccc(O)c1",
        "output": "147"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)Cc1c2ccccc2cc2c(CCC3CCNCC3)noc12.N#Cc1ccc(C=O)s1>>CN(C)Cc1c2ccccc2cc2c(CCC3CCN(Cc4ccc(C#N)s4)CC3)noc12",
        "output": "792"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.O.O=Cc1cccc(OCCCF)c1.[BH4-].[Na+]>>OCc1cccc(OCCCF)c1",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CS(=O)(=O)Cl.C[C@]12C[C@@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1[C@@H]1C[C@@H]1C2=O.c1ccncc1>>C[C@]12C[C@@H](OS(C)(=O)=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1[C@@H]1C[C@@H]1C2=O",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=NO)C(C)=NO.CC(=O)O.CN(C)C=O.CN(CCOc1ccc(C=C2SC(=O)NC2=O)cc1)c1ccccn1.O.[BH4-].[Na+].[Na+].[OH-]>>CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1",
        "output": "762"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCBr.CC(C)=O.COc1cc(C=O)ccc1O.O=C([O-])[O-].[K+].[K+]>>C#CCOc1ccc(C=O)cc1OC",
        "output": "154"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C(=O)Cl)CC1F.CCO.O=S(=O)(O)O>>CCOC(=O)C1(C)CC1F",
        "output": "126"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C.F[P-](F)(F)(F)(F)F.NC1CCN(CCO)CC1>>COc1cc(C(=O)NC2CCN(CCO)CC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(CC(=O)O)C(F)(F)F.CC(Cl)Cl.CCN(C(C)C)C(C)C.CCn1cnc(C(=O)Nc2ccc(Cl)nc2)c1N.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>>CCn1cnc(C(=O)Nc2ccc(Cl)nc2)c1NC(=O)CC(C)C(F)(F)F",
        "output": "692"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClCCl.O.O=C(Cl)c1ccccc1.O=C(NC1CCNCC1)c1ccc(F)cc1.c1ccncc1>>O=C(NC1CCN(C(=O)c2ccccc2)CC1)c1ccc(F)cc1",
        "output": "201"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.Fc1ccc2cnccc2c1.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1ccc2cc(F)ccc2c1",
        "output": "262"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1nc(-c2ccc(C(=O)O)cc2)cs1.Cl.F[P-](F)(F)(F)(F)F.NCCC(F)(F)F.On1nnc2ccccc21>>Cc1nc(-c2ccc(C(=O)NCCC(F)(F)F)cc2)cs1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CN(C)C=O.CNC.F[P-](F)(F)(F)(F)F.O=C(O)C1(c2ccc(Br)cc2)CC1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CN(C)C(=O)C1(c2ccc(Br)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CN1C(=O)NC(=O)C12Cc1cc(N)c(Cl)cc1C2.F[P-](F)(F)(F)(F)F.O=C(O)Cn1c(=O)n(-c2ccccn2)c2ccccc21.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CN1C(=O)NC(=O)C12Cc1cc(Cl)c(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1ccc(C(=O)Cl)cc1.CNC(C)c1nc2ccccc2c(=O)n1-c1ccc(OC)cc1.ClCCl.NC(CO)(CO)CO>>COc1ccc(-n2c(C(C)N(C)C(=O)c3ccc(C(C)(C)C)cc3)nc3ccccc3c2=O)cc1",
        "output": "201"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C[Mg]Br.O=C1CCOc2c(F)cc(F)cc21>>CC1(O)CCOc2c(F)cc(F)cc21",
        "output": "586"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(COc1ccc(-c2c(C#N)c(N)nc(SCc3csc(Nc4ccc(F)cc4)n3)c2C#N)cc1)O[Si](C)(C)C(C)(C)C.CO.Cl.O=C([O-])O.[Na+]>>CC(O)COc1ccc(-c2c(C#N)c(N)nc(SCc3csc(Nc4ccc(F)cc4)n3)c2C#N)cc1",
        "output": "708"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)Oc1ccc(B(O)O)c(F)c1.CCCc1nc(CC)c(Br)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.Cl[Pd]Cl.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCCc1nc(CC)c(-c2ccc(OC(C)C)cc2F)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "871"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1ccc2cc(Br)ccc2c1.OB(O)c1ccc2c3c(cccc13)-c1c-2c(-c2ccccc2)c2ccccc2c1-c1ccccc1>>Brc1ccc2cc(-c3ccc4c5c(cccc35)-c3c-4c(-c4ccccc4)c4ccccc4c3-c3ccccc3)ccc2c1",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)C(C)Oc1ccc(O)cc1.Clc1ccc2ccccc2n1>>COC(=O)C(C)Oc1ccc(Oc2ccc3ccccc3n2)cc1",
        "output": "516"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc(-n2c(=O)[nH]c3ccccc3c2=O)o1.O.O.[Li+].[OH-]>>O=C(O)c1ccc(-n2c(=O)[nH]c3ccccc3c2=O)o1",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.Nc1cccc(CO)c1.O.O=C(Cl)OCCCCl.O=C([O-])[O-].[Na+].[Na+]>>O=C(Nc1cccc(CO)c1)OCCCCl",
        "output": "102"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COCC(COC)N1CCc2cc(N)c(OC)cc2CC1.NC(=O)[C@@H]1[C@H](Nc2nc(Cl)ncc2Cl)[C@H]2C=C[C@@H]1C2>>COCC(COC)N1CCc2cc(Nc3ncc(Cl)c(N[C@@H]4[C@H]5C=C[C@H](C5)[C@@H]4C(N)=O)n3)c(OC)cc2CC1",
        "output": "808"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1cccc(O)c1)[C@H](O)CNC1(c2cc(C(C)(C)C)ccn2)CC1.COC(=O)c1cc(C)nc(OCCCCOS(C)(=O)=O)c1>>COC(=O)c1cc(C)nc(OCCCCOc2cccc(C[C@H](NC(=O)OC(C)(C)C)[C@H](O)CNC3(c4cc(C(C)(C)C)ccn4)CC3)c2)c1",
        "output": "702"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1ccc2c(c1)C(C(=O)O)CCC2.CCn1cc(CNc2ccc(C(C)C)cc2)cn1>>CCn1cc(CN(C(=O)C2CCCc3ccc(C(C)C)cc32)c2ccc(C(C)C)cc2)cn1",
        "output": "315"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "B.C1CCOC1.COc1ccc(Br)c2[nH]c(=O)cc(CC(=O)O)c12>>COc1ccc(Br)c2[nH]c(=O)cc(CCO)c12",
        "output": "231"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CO.COC(=O)c1cc([N+](=O)[O-])cc(S(F)(F)(F)(F)F)c1.[H][H].[Pd]>>COC(=O)c1cc(N)cc(S(F)(F)(F)(F)F)c1",
        "output": "481"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C1COCCN1.NS(=O)(=O)c1cccc(C(=O)O)c1.O=C(n1ccnc1)n1ccnc1>>NS(=O)(=O)c1cccc(C(=O)N2CCOCC2)c1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@@H](N)CO>>C[C@H](CO)NC(=O)OC(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)C.COC[C@H](C)Oc1cc(O)cc(C(=O)O)c1.CS(C)=O.O.O=C([O-])[O-].O=C(c1cnc(Cl)cn1)N1CCC1.[K+].[K+]>>COC[C@H](C)Oc1cc(Oc2cnc(C(=O)N3CCC3)cn2)cc(C(=O)O)c1",
        "output": "210"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(CC(=O)O)cc1OC.O=S(Cl)Cl.c1ccccc1>>COc1ccc(CC(=O)Cl)cc1OC",
        "output": "53"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.N#CC1(CO)CCSCC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCC1(CO)CCSCC1",
        "output": "246"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)C(=O)c1ccc(SC)c(Cl)c1.Cc1ccccc1.Cl.[Na+].[OH-]>>CSc1ccc(C(=O)C(=O)O)cc1Cl",
        "output": "506"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.COC(=O)Cc1ccc2ncccc2c1.ClC(Cl)(Cl)Cl.ClCCl.O=C([O-])O.[Na+].c1ccncc1>>COC(=O)Cc1ccc2ncc(Br)cc2c1",
        "output": "292"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)Nc1nc(Cl)nc2cscc12.CCO.CC[O-].[Na+]>>CCOc1nc(NC(C)C)c2cscc2n1",
        "output": "37"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.O=[N+]([O-])c1ccc(Oc2ccc3c(c2)C(O)CC(c2ccccc2)O3)nc1.c1ccncc1>>CC(=O)OC1CC(c2ccccc2)Oc2ccc(Oc3ccc([N+](=O)[O-])cn3)cc21",
        "output": "254"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)CC1CCNCC1.CCOC(C)=O.COc1cccc([C@H]2O[C@H](CCC(=O)O)c3cccn3-c3ccc(Cl)cc32)c1OC.Cl.ClCCl.On1nnc2ccccc21>>CCOC(=O)CC1CCN(C(=O)CC[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3-n3cccc32)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cc1nc(-c2cccc(F)c2)ncc1C(=O)Nn1ccc2cc([N+](=O)[O-])ccc21.[Pd]>>Cc1nc(-c2cccc(F)c2)ncc1C(=O)Nn1ccc2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1nn(CC(O)c2ccc(OC(F)(F)F)cc2)c(=O)n1-c1ccc(N2CCN(c3ccc(O[Si](C)(C)C(C)(C)C)cc3)CC2)cc1.ClCCl.O.[F-]>>Cc1nn(CC(O)c2ccc(OC(F)(F)F)cc2)c(=O)n1-c1ccc(N2CCN(c3ccc(O)cc3)CC2)cc1",
        "output": "754"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COc1c(F)cc(F)cc1-c1ncc(OC[C@@H](N)Cc2ccccc2)cc1-c1ccc2[nH]nc(C)c2c1>>Cc1n[nH]c2ccc(-c3cc(OC[C@@H](N)Cc4ccccc4)cnc3-c3cc(F)cc(F)c3O)cc12",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(=O)c1cnn(-c2cc(C#N)c(Br)cn2)c1.CCOC(C)=O.CS(=O)(=O)c1cccc(B(O)O)c1.Cl[Pd]Cl.O.O.O=P([O-])([O-])[O-].[Fe+2].[K+].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)c1cnn(-c2cc(C#N)c(-c3cccc(S(C)(=O)=O)c3)cn2)c1",
        "output": "833"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCc1ccccc1-c1ccc2nc(-c3ccoc3)cn2c1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>OCc1ccccc1-c1ccc2nc(-c3ccoc3)cn2c1",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)c1ccc2nccnc2c1.N>>NC(=O)c1ccc2nccnc2c1",
        "output": "67"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1c(C(C)C)nc(C(C)C)c(C(=O)OCC)c1-c1ccc(F)cc1.O>>CCOC(=O)c1c(C(C)C)nc(C(C)C)c(CO)c1-c1ccc(F)cc1",
        "output": "383"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COCc1cc2ccccc2cn1.N.O.O=S(=O)(O)O.O=[N+]([O-])O>>COCc1cc2c([N+](=O)[O-])cccc2cn1",
        "output": "21"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(C)=O.Nc1nccc(Oc2ccc(NC(=O)C(F)(F)F)c(F)c2)c1[N+](=O)[O-].[H][H].[Pd]>>Nc1nccc(Oc2ccc(NC(=O)C(F)(F)F)c(F)c2)c1N",
        "output": "269"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.O=C(CN1CCC(c2ccccc2)(c2ccccc2)C1=O)N1CCN(C(=O)OCc2ccccc2)CC1>>O=C(CN1CCC(c2ccccc2)(c2ccccc2)C1=O)N1CCNCC1",
        "output": "428"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)N(C)C.CC(O)(C(=O)O)C(F)(F)F.Nc1ccc(C(=O)c2ccccn2)cc1.O.O=S(Cl)Cl>>CC(O)(C(=O)Nc1ccc(C(=O)c2ccccn2)cc1)C(F)(F)F",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CI.CN(C)C=O.COc1ccc(C2(C#N)CCc3nc[nH]c(=O)c3C2)c2c1oc1ccccc12.O=C([O-])[O-].[Cs+].[Cs+]>>COc1ccc(C2(C#N)CCc3ncn(C)c(=O)c3C2)c2c1oc1ccccc12",
        "output": "570"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CC(C)(C)CCO.C1CCOC1.CCOC(=O)N=NC(=O)OCC.Oc1ccc(Cl)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C#CC(C)(C)CCOc1ccc(Cl)cc1",
        "output": "550"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1.O.O=C(O)C(F)(F)F.O=C(O)c1ccc(-c2ccccc2)cn1.On1nnc2ccccc21>>O=C(NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1)c1ccc(-c2ccccc2)cn1",
        "output": "738"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.Clc1ccnc(Cl)n1.Nc1ccccc1>>Clc1nccc(Nc2ccccc2)n1",
        "output": "161"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.CN1CCNCC1.Cc1ccc(Oc2ccc3nc(NC(=O)CCl)sc3c2)cc1NC(=O)c1cccc(C2(C#N)CC2)c1>>Cc1ccc(Oc2ccc3nc(NC(=O)CN4CCN(C)CC4)sc3c2)cc1NC(=O)c1cccc(C2(C#N)CC2)c1",
        "output": "340"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)/C=C/c1ccc2ccccc2c1[N+](=O)[O-].Cl.O.[Na+].[OH-]>>O=C(O)/C=C/c1ccc2ccccc2c1[N+](=O)[O-]",
        "output": "58"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(C)=O.N#Cc1ccc(Br)cc1F.O.[Cl-].[Cl-].[N-]=[N+]=[N-].[Na+].[Zn+2]>>Fc1cc(Br)ccc1-c1nnn[nH]1",
        "output": "390"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CNC.ClCCl.O=Cc1cccc(C(=O)O)n1.[Na+]>>CN(C)Cc1cccc(C(=O)O)n1",
        "output": "829"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)COc1cccc2c1CCCC2C(=O)N(Cc1ccccc1)Cc1ccccc1.COCCOC.[Na+].[OH-]>>O=C(O)COc1cccc2c1CCCC2C(=O)N(Cc1ccccc1)Cc1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CN1C(=C2SC(=Nc3ccc(N)cc3)N(Cc3ccccc3)C2=O)Sc2ccccc21.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CN1C(=C2SC(=Nc3ccc(NC(=O)C(F)(F)F)cc3)N(Cc3ccccc3)C2=O)Sc2ccccc21",
        "output": "106"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)COC(=O)Nc1ccc(-c2cnc3c(-c4ccc(N5CCNCC5)cc4)cnn3c2N)cc1.CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O.CCN(CC)CC.O=C([O-])[O-].Oc1cccc2[nH]nnc12.[Na+].[Na+]>>CC(C)COC(=O)Nc1ccc(-c2cnc3c(-c4ccc(N5CCN(C(=O)[C@@H](NC(=O)OCc6ccccc6)C(C)C)CC5)cc4)cnn3c2N)cc1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(N)c1cccc2c1CCN2C.COc1ccc(-c2cc(C=O)ccc2OC)cc1.COc1ccc(-c2cc(CNC(C)c3ccnc4ccccc34)ccc2OC)cc1.[BH3-]C#N.[Na+]>>COc1ccc(-c2cc(CNC(C)c3cccc4c3CCN4C)ccc2OC)cc1",
        "output": "683"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)S(=O)(=O)Cl.CC(CN)c1ccc(-c2ccsc2)s1.CCN(CC)CC.ClCCl>>CC(CNS(=O)(=O)C(C)C)c1ccc(-c2ccsc2)s1",
        "output": "493"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CN(C)C=O.O.O=Cc1ccc(Br)cc1N1CCC(CO)CC1.c1c[nH]cn1>>CC(C)(C)[Si](OCC1CCN(c2cc(Br)ccc2C=O)CC1)(c1ccccc1)c1ccccc1",
        "output": "602"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cl.O=C(O)C(O)c1ccc(Cl)cc1>>COC(=O)C(O)c1ccc(Cl)cc1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.NCC1CCOCC1>>CC(C)(C)OC(=O)NCC1CCOCC1",
        "output": "631"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CBr.CN(C)C=O.CNCCC=C1c2ccccc2C=Cc2ccccc21.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CN(C)CCC=C1c2ccccc2C=Cc2ccccc21",
        "output": "467"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCCc1ccc(O)cc1.O=[N+]([O-])O>>CCCc1ccc(O)c([N+](=O)[O-])c1",
        "output": "21"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCOC(C)=O.COc1ccccc1-n1nnc2cc(F)c(N)cc21.ClCCl.O.O=C1OC(=O)C2=C1CCCC2>>COc1ccccc1-n1nnc2cc(F)c(N3C(=O)C4=C(CCCC4)C3=O)cc21",
        "output": "410"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)O.CCN(C(C)C)C(C)C.CCO[C@@H]1C[C@@H]2CN(C(=O)[C@@H](N)C3CCC(F)(F)CC3)[C@H](C(=O)N[C@@H]3CCOc4ccccc43)CN2C1.CN(C(=O)OC(C)(C)C)[C@@H](CO)C(=O)O.COc1nc(OC)nc([N+]2(C)CCOCC2)n1.Cl.Cl.[Cl-]>>CCO[C@@H]1C[C@@H]2CN(C(=O)[C@@H](NC(=O)[C@H](CO)N(C)C(=O)OC(C)(C)C)C3CCC(F)(F)CC3)[C@H](C(=O)N[C@@H]3CCOc4ccccc43)CN2C1",
        "output": "133"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNc1cc(Cl)cc(NCCOC)c1[N+](=O)[O-].CO.C[O-].[Na+]>>CNc1cc(OC)cc(NCCOC)c1[N+](=O)[O-]",
        "output": "57"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Cn1cnc(-c2cc3nccc(Oc4ccc(N)cc4)c3s2)c1.O=C(Cc1ccccc1)N=C=S>>Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4)c3s2)c1",
        "output": "961"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)Sc1ncnc2c(C3=CC(=O)C(CO)C3)csc12.CCN(C(C)C)C(C)C.COCCl.ClCCl>>COCOCC1CC(c2csc3c(SC(C)(C)C)ncnc23)=CC1=O",
        "output": "598"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.C=CCn1c(=O)cnc2ccc(F)cc21.O.O=[Os](=O)(=O)=O.[Na+].[O-][I+3]([O-])([O-])[O-]>>O=CCn1c(=O)cnc2ccc(F)cc21",
        "output": "571"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)Cn1nc(-c2ccc(F)cc2F)cc(CN2C(=O)c3ccccc3C2=O)c1=O.Cc1cc(-c2cc(C(=O)O)c(=O)n(CCCc3ccccc3Cl)n2)ccc1F>>Cc1cc(-c2cc(CO)c(=O)n(CCCc3ccccc3Cl)n2)ccc1F",
        "output": "293"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(Br)ccc1O.Cc1cccc(B(O)O)c1.ClCCl>>COc1cc(Br)ccc1Oc1cccc(C)c1",
        "output": "920"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)OCc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)OCc1ccccc1",
        "output": "538"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCO.CC[C@@H]1CCCN1c1cc(-c2cc(F)c(C#N)c(SC)c2)nc(NC)n1.NN>>CC[C@@H]1CCCN1c1cc(-c2cc(SC)c3c(N)n[nH]c3c2)nc(NC)n1",
        "output": "945"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2ccc(C(N)=O)cc2)CC1.CCN(CC)CC.ClC(Cl)(Cl)Cl.ClC(Cl)Cl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCC(c2ccc(C#N)cc2)CC1",
        "output": "374"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C=C1C[C@@H](CO)N(C(=O)OC(C)(C)C)C1.CCOC(C)=O.Fc1cc(F)c(CBr)cc1F.[Cl-].[H-].[NH4+].[Na+]>>C=C1C[C@@H](COCc2cc(F)c(F)cc2F)N(C(=O)OC(C)(C)C)C1",
        "output": "464"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1cnc(CNS(=O)(=O)c2ccc(F)c(Cl)c2)c(C(F)(F)F)n1.C[Sn+](C)C.ClCCCl.[OH-]>>O=C(O)c1cnc(CNS(=O)(=O)c2ccc(F)c(Cl)c2)c(C(F)(F)F)n1",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CCCCCBr.CN(C)C=O.O.O=C([O-])[O-].O=c1nc(-c2ccccn2)sc2ccc(O)cc12.[K+].[K+]>>CC(C)(C)OC(=O)CCCCCOc1ccc2sc(-c3ccccn3)nc(=O)c2c1",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Nc1ccc(Cl)cn1.O=C(O)c1ccnc(Cl)c1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2]>>O=C(O)c1ccnc(Nc2ccc(Cl)cn2)c1",
        "output": "606"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.Cc1cccc(C)n1.N#Cc1cc2c(Cl)ccnc2cc1OCc1ccccc1.O=[N+]([O-])c1ccc(O)cc1.[Na]>>N#Cc1cc2c(Oc3ccc([N+](=O)[O-])cc3)ccnc2cc1OCc1ccccc1",
        "output": "351"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=O.CC#N.CC(=O)O.COC(=O)C(CNCc1ccc(Cl)c(Cl)c1)NC(=O)OC(C)(C)C.O=C([O-])O.[BH3-]C#N.[Na+].[Na+]>>COC(=O)C(CN(C)Cc1ccc(Cl)c(Cl)c1)NC(=O)OC(C)(C)C",
        "output": "69"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccccc1.NC(=O)c1cc(Br)nc2c1[nH]c1cc(N)ccc12.O=C(Cl)COCCCl>>NC(=O)c1cc(Br)nc2c1[nH]c1cc(NC(=O)COCCCl)ccc12",
        "output": "9"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCN1.CCCCCn1c2nc(Br)[nH]c2c(=O)n2c(CCC(=O)O)nnc12.CCN(CC)CC.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.ClCCl.F[P-](F)(F)(F)(F)F>>CCCCCn1c2nc(Br)[nH]c2c(=O)n2c(CCC(=O)N3CCOCC3)nnc12",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)Cc1ccc2ccc(C(F)(F)F)nc2c1.Cl>>O=C(O)Cc1ccc2ccc(C(F)(F)F)nc2c1",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)CC(=O)c1ccccc1.Cl.[Na+].[OH-]>>O=C(O)CC(=O)c1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(=O)N1CCNCC1.Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(OC(=O)CCCCl)c3cc(Cl)ccc32)c(C)c1.O.O=C([O-])[O-].[I-].[Na+].[Na+].[Na+]>>CC(=O)N1CCN(CCCC(=O)OC2CCCN(C(=O)c3ccc(NC(=O)c4ccccc4C)cc3C)c3ccc(Cl)cc32)CC1",
        "output": "138"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCN(C)C(=O)c1ccc([N+](=O)[O-])cc1.[C].[Pd]>>CCOC(=O)CCN(C)C(=O)c1ccc(N)cc1",
        "output": "28"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)CC(=O)Cl.Cc1cccc(C(=O)c2[nH]c3cc(Cl)ccc3c2N)c1>>Cc1cccc(C(=O)c2[nH]c3cc(Cl)ccc3c2NC(=O)CC(C)C)c1",
        "output": "422"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOc1cc(CN2CCC(N)CC2)ccc1OC.Clc1ccc(-c2nc3ccccc3[nH]2)cn1.OCCO>>CCOc1cc(CN2CCC(Nc3ccc(-c4nc5ccccc5[nH]4)cn3)CC2)ccc1OC",
        "output": "70"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)Cc1c(C(=O)OCC)c2cc(Oc3ccc(C(F)(F)F)cc3)ccc2n1-c1ccc(OC(C)C)cc1.Cl.[Na+].[OH-]>>CCOC(=O)c1c(CC(=O)O)n(-c2ccc(OC(C)C)cc2)c2ccc(Oc3ccc(C(F)(F)F)cc3)cc12",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCc1noc(NC(=O)OCC(Cl)(Cl)Cl)c1C.Cl.Cl.Fc1cccc(-c2nccc(N3CCNCC3)n2)c1F.O>>CCc1noc(NC(=O)N2CCN(c3ccnc(-c4cccc(F)c4F)n3)CC2)c1C",
        "output": "980"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=[N+]([O-])c1cc(F)c(F)cc1F.OCc1cccc(F)c1>>O=[N+]([O-])c1cc(F)c(OCc2cccc(F)c2)cc1F",
        "output": "485"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.OCc1cc2ccoc2cn1>>O=Cc1cc2ccoc2cn1",
        "output": "263"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.Nc1nccc(-c2ccccc2)n1.O.O=C([O-])[O-].[Ca+2].[NH4+].[OH-]>>Nc1ncc(Br)c(-c2ccccc2)n1",
        "output": "381"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCn1ncc(C)c1-c1cc(C(=O)OC)sc1Cl.O.[K+].[OH-]>>CCn1ncc(C)c1-c1cc(C(=O)O)sc1Cl",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#CCBr.CC(C)=O.CCn1nnn(-c2cc(O)c(F)cc2Cl)c1=O.O=C([O-])[O-].[K+].[K+]>>C#CCOc1cc(-n2nnn(CC)c2=O)c(Cl)cc1F",
        "output": "154"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C1COCCN1.COc1cccc([N+](=O)[O-])c1NC(=O)CBr>>COc1cccc([N+](=O)[O-])c1NC(=O)CN1CCOCC1",
        "output": "443"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=C[SiH2]CCCCl.CCC(C)=O.[I-].[Na+]>>CC(C)=C[SiH2]CCCI",
        "output": "97"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CCC1(CC)C(=O)N(C(C)C)c2ccc(N)cc21>>CCC1(CC)C(=O)N(C(C)C)c2ccc(NC(C)=O)cc21",
        "output": "6"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.O=S(=O)([O-])[O-].O=[N+]([O-])O.Oc1cc(F)c(F)cc1Br.[NH4+].[Ni+]>>O=[N+]([O-])c1c(O)c(Br)cc(F)c1F",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1cnc(Cl)cn1.Cn1nnc(-c2ccc(F)cc2)c1CO.[H-].[Na+]>>COC(=O)c1cnc(OCc2c(-c3ccc(F)cc3)nnn2C)cn1",
        "output": "209"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.C[C@]12CC[C@@H]3c4cc([N+](=O)[O-])c(O)cc4CC[C@H]3[C@@H]1CCC2=O.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1cc2c(cc1[N+](=O)[O-])[C@H]1CC[C@]3(C)C(=O)CC[C@H]3[C@@H]1CC2",
        "output": "746"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCCC.CCOC(C)=O.CCOC(C)=O.Cc1ccc(S(=O)(=O)Cl)cc1.O.OC1CCOC1.c1ccncc1>>Cc1ccc(S(=O)(=O)OC2CCOC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COc1ccccc1C=O.Cc1ccccc1.N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1.O=S(=O)([O-])[O-].[BH4-].[Mg+2].[Na+]>>COc1ccccc1CN[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1",
        "output": "468"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.N#Cc1ccc(F)cc1Cl.OCc1sc(-c2ccc(C(F)(F)F)nc2)nc1CCCOCc1ccccc1.[H-].[Na+]>>N#Cc1ccc(OCc2sc(-c3ccc(C(F)(F)F)nc3)nc2CCCOCc2ccccc2)cc1Cl",
        "output": "485"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CN(CCc1ccccc1NS(=O)(=O)c1ccccc1)C(=O)OC(C)(C)C.Cl.ClCCl>>CNCCc1ccccc1NS(=O)(=O)c1ccccc1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)[C@@H](CCN1C(=O)c2ccccc2C1=O)Oc1c(Br)cc(-c2c3ccccc3c(Br)c3sc4ccccc4c23)cc1Br.C[Si](C)(C)I.ClCCl>>O=C(O)[C@@H](CCN1C(=O)c2ccccc2C1=O)Oc1c(Br)cc(-c2c3ccccc3c(Br)c3sc4ccccc4c23)cc1Br",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COc1cccc([N+](=O)[O-])c1C.[Pd]>>COc1cccc(N)c1C",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(OC2CCNCC2)CC1.CS(C)=O.N#Cc1ccc(F)cc1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCC(OC2CCN(c3ccc(C#N)cc3)CC2)CC1",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Nc1ncnc2nc[nH]c12.O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>>OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO",
        "output": "223"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cl.N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1.O=C(O)CN1CCN(CC2CCCO2)CC1>>O=C(CN1CCN(CC2CCCO2)CC1)N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1",
        "output": "133"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCCl.OCc1cc2n(n1)-c1ccccc1CC2.[Mn+2].[O-2]>>O=Cc1cc2n(n1)-c1ccccc1CC2",
        "output": "573"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.COc1ccc([N+](=O)[O-])c(Cl)n1.Cl[Sn]Cl>>COc1ccc(N)c(Cl)n1",
        "output": "269"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(O)CN.O=[N+]([O-])c1cnc2ccccc2c1Cl>>CC(O)CNc1c([N+](=O)[O-])cnc2ccccc12",
        "output": "78"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.Cc1cc(C[C@@H](OC(=O)N2CCC(n3c(=O)[nH]c4c5ccccc5ncc43)CC2)C(=O)O)cc(C)c1OCc1ccccc1.[H][H].[Pd]>>Cc1cc(C[C@@H](OC(=O)N2CCC(n3c(=O)[nH]c4c5ccccc5ncc43)CC2)C(=O)O)cc(C)c1O",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cc(O)c2c(C)c(Cc3ccc(Cl)cc3)c(=O)[nH]c2c1.O.O=P(Cl)(Cl)Cl>>Cc1cc(O)c2c(C)c(Cc3ccc(Cl)cc3)c(Cl)nc2c1",
        "output": "100"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1.O.[Cl-].[NH4+]>>COc1ccc2c(Cc3cccc(C(N)=O)n3)c(-c3ccccc3)nn2c1",
        "output": "136"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCN.CN(C(=O)Cl)c1ccc(SC(F)(F)F)cc1F>>CCNC(=O)N(C)c1ccc(SC(F)(F)F)cc1F",
        "output": "454"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COc1c(F)cc(Br)cc1F.N#C[Cu].O>>COc1c(F)cc(C#N)cc1F",
        "output": "531"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCCc1ccccc1.CCN(CC)CC.CN(C)C=O.O.O=c1[nH]c2ccccc2n1C1CCNCC1.[I-].[Na+]>>O=c1[nH]c2ccccc2n1C1CCN(CCc2ccccc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CO.COc1cnc(C#N)c(C)c1.N>>COc1cnc(CN)c(C)c1",
        "output": "205"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COc1ccc(C[C@H](NC(=O)[C@@H](C)NC(=O)CC(C)(C)O)C(=O)N[C@@H](CC2CCCC2)C(=O)[C@@]2(C)CO2)cc1OCc1ccccc1.[Pd]>>COc1ccc(C[C@H](NC(=O)[C@@H](C)NC(=O)CC(C)(C)O)C(=O)N[C@@H](CC2CCCC2)C(=O)[C@@]2(C)CO2)cc1O",
        "output": "23"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.Cl.ClCCl.O.O=C(O)c1cc(F)c(Br)c(CO)c1F>>CC(=O)OCc1c(F)c(C(=O)O)cc(F)c1Br",
        "output": "254"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCCNC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCCN)c1=O.CS(=O)(=O)Cl>>CCOCCNC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCCNS(C)(=O)=O)c1=O",
        "output": "493"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)OC(C)C.CCOC(C)=O.CN(C)C=O.NCCCO.O.O=C(Br)C(=O)Br.O=C(O)c1cc(N(CCBr)CCBr)c([N+](=O)[O-])cc1[N+](=O)[O-].c1ccccc1>>O=C(NCCCO)c1cc(N(CCBr)CCBr)c([N+](=O)[O-])cc1[N+](=O)[O-]",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.O=C(c1ccc(F)cc1)C1CCNCC1.OCCBr>>O=C(c1ccc(F)cc1)C1CCN(CCO)CC1",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.OCc1cccc(CN2CCc3sccc3C2)c1>>CS(=O)(=O)OCc1cccc(CN2CCc3sccc3C2)c1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCOC(=O)C1(Cc2ccc(OCCc3ccc(-c4ccc(OC)cc4)cc3)cc2)CCC1.Cl.[Na+].[OH-]>>COc1ccc(-c2ccc(CCOc3ccc(CC4(C(=O)O)CCC4)cc3)cc2)cc1",
        "output": "281"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1ccc(Cl)c(CC(=O)O)c1.C[C@@H]1N[C@@H](CO[Si](C)(C)C(C)(C)C)Cc2c(CCC(C)(C)O)cccc21.ClCCl.F[P-](F)(F)(F)(F)F>>COc1ccc(Cl)c(CC(=O)N2[C@@H](CO[Si](C)(C)C(C)(C)C)Cc3c(CCC(C)(C)O)cccc3[C@@H]2C)c1",
        "output": "633"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCBr.CC#N.O=C([O-])[O-].Oc1ccccc1.[K+].[K+]>>C=CCOc1ccccc1",
        "output": "77"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)C(=O)Cl.CC1(C)CCC(n2nc(-c3cc(CN)c(F)cc3Cl)[nH]c2=O)CC1>>CC1(C)CCC(n2nc(-c3cc(CNC(=O)C(C)(C)C)c(F)cc3Cl)[nH]c2=O)CC1",
        "output": "206"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.COc1cc(OC)cc(-c2cc(C=O)c([N+](=O)[O-])cc2F)c1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.OCCO>>COc1cc(OC)cc(-c2cc(C3OCCO3)c([N+](=O)[O-])cc2F)c1",
        "output": "117"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CC(=O)Cl.CO.CO.Cc1cc(O)cc(C(=O)O)c1>>COC(=O)c1cc(C)cc(O)c1",
        "output": "195"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1ccc2c(c1)c(C=O)cn2C>>Cn1cc(C=O)c2cc(O)ccc21",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1[nH]c2c(F)ccc(C)c2c1CCN.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2c(c1)OCO2.O=C([O-])O>>Cc1[nH]c2c(F)ccc(C)c2c1CCNC(=O)c1ccc2c(c1)OCO2",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNC1.Cc1nc2c(OC3CCOc4cc(F)cc(F)c43)cc(C(=O)O)cc2n1C>>Cc1nc2c(OC3CCOc4cc(F)cc(F)c43)cc(C(=O)N3CCCC3)cc2n1C",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.Cc1c[nH]nc1C(=O)O.ClCCl.ClCCl.Nc1cccc2c1OC(F)(F)O2>>Cc1c[nH]nc1C(=O)Nc1cccc2c1OC(F)(F)O2",
        "output": "844"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc(F)c(B(O)O)c(F)c1.ClCCl.Cl[Pd]Cl.O=C(O)c1cccc(Br)n1.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1cc(F)c(-c2cccc(C(=O)O)n2)c(F)c1",
        "output": "869"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CC(C)(C)OC(=O)NC1(C)CNC(=O)C12CC2.CCCCCC.CCOC(C)=O.CN(C)C=O.[H-].[Na+]>>CC(C)(C)OC(=O)NC1(C)CN(Cc2ccccc2)C(=O)C12CC2",
        "output": "774"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cc1ccccc1.O=C(O)C12CC(c3ccccc31)c1ccc(Cl)cc12.O=S(Cl)Cl.[Na+].[OH-]>>COC(=O)C12CC(c3ccccc31)c1ccc(Cl)cc12",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(=O)N(c1ccccc1)C1CCCN(Cc2ccccc2)C1.CO.[Pd]>>CCC(=O)N(c1ccccc1)C1CCCNC1",
        "output": "84"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#C[Si](C)(C)C.CC(C)(C)OC(=O)NNC(=O)Cc1ccc(Br)cc1.CCN(CC)CC.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O.[Cu]I>>CC(C)(C)OC(=O)NNC(=O)Cc1ccc(C#C[Si](C)(C)C)cc1",
        "output": "671"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc(S(=O)(=O)NC(C(=O)OC(C)(C)C)c2ccccc2)c1.[Li+].[OH-]>>CC(C)(C)OC(=O)C(NS(=O)(=O)c1cccc(C(=O)O)c1)c1ccccc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCN(c2cccc3c2NC(=O)CC3)CC1.CC(C)(C)[O-].CI.[K+]>>CN1C(=O)CCc2cccc(N3CCN(C(=O)OC(C)(C)C)CC3)c21",
        "output": "237"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)CCCN1CCC(CO)CC1.CCN(CC)CC.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)CCCN1CCC(C=O)CC1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C[C@]1(c2cc(N)ccc2F)N=C(N)OCC1(F)F.O=C(O)c1ccc(OCC(F)(F)F)cn1>>C[C@]1(c2cc(NC(=O)c3ccc(OCC(F)(F)F)cn3)ccc2F)N=C(N)OCC1(F)F",
        "output": "985"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)c1cc(N2CC3CNCC3C2)nc(C(F)(F)F)n1.F[P-](F)(F)(F)(F)F.O=C(O)c1ccccc1-n1nccn1>>CN(C)c1cc(N2CC3CN(C(=O)c4ccccc4-n4nccn4)CC3C2)nc(C(F)(F)F)n1",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(=O)OCn1ccnc1[C@@H]1Nc2ccccc2[C@@H]2NCC[C@@H]21.CCN(CC)CC.CCOP(=O)(C#N)OCC.CN(C)C=O.Cc1ccn(-c2ccc(C(=O)N[C@@H]3CCC(F)(F)C[C@@H]3C(=O)O)cc2)n1.Cl.Cl.O>>Cc1ccn(-c2ccc(C(=O)N[C@@H]3CCC(F)(F)C[C@@H]3C(=O)N3CC[C@@H]4[C@H](c5nccn5COC(=O)C(C)(C)C)Nc5ccccc5[C@@H]43)cc2)n1",
        "output": "633"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCCn1c2ccccc2c2nc(SCC(=O)OC(C)(C)C)n(-c3ccccc3)c(=O)c21.O=C(O)C(F)(F)F>>CCCn1c2ccccc2c2nc(SCC(=O)O)n(-c3ccccc3)c(=O)c21",
        "output": "278"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.COC(=O)[C@@H](N)CCCCO.Cl.ClCCl.O=C(O)[C@H](Cc1ccsc1)NN1C(=O)c2ccccc2C1=O.Oc1cccc2[nH]nnc12>>COC(=O)[C@H](CCCCO)NC(=O)[C@H](Cc1ccsc1)NN1C(=O)c2ccccc2C1=O",
        "output": "129"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.COC(=O)CBr.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1O.[H-].[Na+]>>COC(=O)COc1c(OC)cc(Cc2cnc(N)nc2N)cc1OC",
        "output": "557"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1cc2c(C)c(Oc3ccc(O)c(C(=O)c4ccc(F)cc4)c3)c(C)cc2[nH]1.CCOC(C)=O.CC[SiH](CC)CC.ClCCl.O.O=C(O)C(F)(F)F>>CCOC(=O)c1cc2c(C)c(Oc3ccc(O)c(Cc4ccc(F)cc4)c3)c(C)cc2[nH]1",
        "output": "181"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(C(C)C)C(C)C.Cl.ClCCl.Nc1ncnc2c1c(I)cn2[C@@H]1C[C@H](CO)C1.O=S1CCNCC1.[Na+]>>Nc1ncnc2c1c(I)cn2[C@@H]1C[C@H](CN2CCS(=O)CC2)C1",
        "output": "371"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C(=O)c2c[nH]c3ncc(-c4cccc(N5CCNCC5)c4)nc23)CCCCC1.CCN=C=NCCCN(C)C.Cl.ClCCl.N#CCC(=O)O.On1nnc2ccccc21>>CC1(C(=O)c2c[nH]c3ncc(-c4cccc(N5CCN(C(=O)CC#N)CC5)c4)nc23)CCCCC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.CC(C)n1cnc2cnc(Nc3ccnc(Cl)n3)cc21.CCN(CC)CC.O.OC1CCNCC1>>CC(C)n1cnc2cnc(Nc3ccnc(N4CCC(O)CC4)n3)cc21",
        "output": "36"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCCCCNC(=O)CC(C)(C)CCO.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCCCCCNCCC(C)(C)CCO",
        "output": "112"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)c1cc(OCC)c(-n2cccc2)c(OCC)c1.Cc1ccccc1.[H-]>>CCOc1cc(CO)cc(OCC)c1-n1cccc1",
        "output": "311"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1c(N2CCNCC2)c2ccccc2n(-c2ccccc2)c1=O.CI.CN(C)C=O.[H-].[Na+]>>CCOC(=O)c1c(N2CCN(C)CC2)c2ccccc2n(-c2ccccc2)c1=O",
        "output": "483"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CO.Cl.O=C(O)Cc1cccc(-c2cccc3[nH]ccc23)c1>>COC(=O)Cc1cccc(-c2cccc3[nH]ccc23)c1",
        "output": "195"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1.O=C(O)C1CC(Cl)C1>>O=C(N[C@@H]1CC[C@@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1)C1CC(Cl)C1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.C[C@@H]1NC(=O)C(C)(C)[C@@H]1O[Si](C)(C)C(C)(C)C.N#Cc1ccc(I)cc1C(F)(F)F.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>C[C@H]1[C@@H](O[Si](C)(C)C(C)(C)C)C(C)(C)C(=O)N1c1ccc(C#N)c(C(F)(F)F)c1",
        "output": "921"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)CO.CCCSC(C)CC(=O)OC.Cc1ccc(S(=O)(=O)O)cc1>>CCCSC(C)CC(=O)OCC(C)C",
        "output": "289"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCCl.Nc1cnc2cccnc2c1Cl.O=C(Cl)CCCCl>>O=C(CCCCl)Nc1cnc2cccnc2c1Cl",
        "output": "422"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1ccc(-c2ccc(OC)c(-c3ccc(-n4cccn4)nc3CN3C(=O)O[C@H](c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H]3C)c2)c(C)c1.O=C(O)C(F)(F)F.[Li+].[OH-]>>COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(-n2cccn2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CO.Cc1ccc(S(=O)(=O)n2ccc3c(N(C)C4COCCN(C(=O)OC(C)(C)C)C4)ncnc32)cc1.Cl.ClCCl.O=C([O-])[O-]>>Cc1ccc(S(=O)(=O)n2ccc3c(N(C)C4CNCCOC4)ncnc32)cc1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCc1c(CNC)oc2ccccc12.CN(C)C=O.O.O=C(O)/C=C/c1cnc2c(c1)CCC(=O)N2.On1nnc2ccccc21>>CCc1c(CN(C)C(=O)/C=C/c2cnc3c(c2)CCC(=O)N3)oc2ccccc12",
        "output": "811"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NCCC(O)c1coc(-c2ccc(F)cc2)n1.O=C(O)c1cccc(-c2noc(C(F)(F)F)n2)c1>>O=C(NCCC(O)c1coc(-c2ccc(F)cc2)n1)c1cccc(-c2noc(C(F)(F)F)n2)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.Cl.Nc1cc2ccccc2cc1C(=O)O.O=C=Nc1c(Cl)cccc1Cl>>O=C(Nc1cc2ccccc2cc1C(=O)O)Nc1c(Cl)cccc1Cl",
        "output": "473"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCc1cnc(Cl)c(C(=O)OC)c1.[Li+].[OH-]>>CCCCc1cnc(Cl)c(C(=O)O)c1",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COCCOCC(=O)Cl.Nc1cc(CCl)ccn1>>COCCOCC(=O)Nc1cc(CCl)ccn1",
        "output": "332"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)N(Cc1ccccc1)CC(O)c1ccc(N)c(C(F)(F)F)c1.CO.Cl.[H][H].[Pd]>>CC(C)(C)NCC(O)c1ccc(N)c(C(F)(F)F)c1",
        "output": "84"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCCCCCC(=O)O.C=CCCCCCCCCO>>C=CCCCCCCCCOC(=O)CCCCCC=C",
        "output": "47"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)OC(C)(C)C.O.O.[Li]O>>CC(C)(C)OC(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.Cc1cnc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3C=O)cn(C)c2=O)s1.ClCCl.[BH4-].[Na+]>>Cc1cnc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3CO)cn(C)c2=O)s1",
        "output": "476"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)CCC(C)(C)[N+](=O)[O-].[Na+].[OH-]>>CC(C)(CCC(=O)O)[N+](=O)[O-]",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)C(C)c1ccc2c(c1)OCO2.ClCCCl.O=C(O)c1ccc2c(c1)OCO2.O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3>>COC(=O)C(C)c1cc2c(cc1C(=O)c1ccc3c(c1)OCO3)OCO2",
        "output": "275"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCC.CN(C)P(=O)(N(C)C)N(C)C.O.O=C(O)c1ccc(NCCCCCCCCCCCO)cc1.OCC(O)CI.[Na+].[OH-]>>O=C(OCC(O)CO)c1ccc(NCCCCCCCCCCCO)cc1",
        "output": "196"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.ClC(Cl)Cl.NC(=O)c1ccc2ncccc2c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C([O-])O.[Na+]>>N#Cc1ccc2ncccc2c1",
        "output": "374"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCOc1cccc(O)c1.CN(C)C=O.OCCCBr.[H-].[Na+]>>CCCCCOc1cccc(OCCCO)c1",
        "output": "75"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(CC)CC.CCO.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COC(=O)C1CCC(CN)CC1.ClCCl.Cn1cc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1C(=O)O.F[B-](F)(F)F>>COC(=O)C1CCC(CNC(=O)c2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cn2C)CC1",
        "output": "137"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cc1ccc(N2CCN(c3cncc(C4CC(C)(C)c5cc(C(=O)O)ccc5N4)c3)CC2)c(C)c1.Cl.ClCCl.NS(=O)(=O)C1CC1>>Cc1ccc(N2CCN(c3cncc(C4CC(C)(C)c5cc(C(=O)NS(=O)(=O)C6CC6)ccc5N4)c3)CC2)c(C)c1",
        "output": "580"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Nn1nc(Cl)c2ccccc2c1=O.O=C(O)Cc1cc(F)cc(F)c1>>O=C(Cc1cc(F)cc(F)c1)Nn1nc(Cl)c2ccccc2c1=O",
        "output": "459"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](n2ccc3c(N[C@H]4CCc5ccccc54)ncnc32)C[C@H]1CO.C[N+]1([O-])CCOCC1.ClCCl>>CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](n2ccc3c(N[C@H]4CCc5ccccc54)ncnc32)C[C@H]1C=O",
        "output": "142"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1OCc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2>>NOCc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2",
        "output": "452"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)C(C)n1c(=O)n2c3c(cc(Br)cc31)CCC2.Cl.O.[Li+].[OH-]>>CC(C(=O)O)n1c(=O)n2c3c(cc(Br)cc31)CCC2",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccc2oc3ccc(Br)cc3c2c1.C1COCCOCCOCCOCCOCCO1.Clc1ccccc1Cl.O=C([O-])[O-].[Cu].[K+].[K+].c1ccc2c(c1)[nH]c1ccccc12>>Brc1ccc2oc3ccc(-n4c5ccccc5c5ccccc54)cc3c2c1",
        "output": "349"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COc1cccc(S(=O)(=O)N2CCOCC2)c1.ClCCl>>O=S(=O)(c1cccc(O)c1)N1CCOCC1",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCCCC1.CN(C)C=O.C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3cc(F)cnc3N12.Cc1ccccc1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li]C(C)CC>>C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3cc(F)c(C=O)nc3N12",
        "output": "641"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)c1ccc2[nH]c(C#N)c(-c3ccccc3)c2c1.Cl.N#CC1(C(=O)O)N=c2ccccc2=C1c1ccccc1>>N#Cc1[nH]c2ccc(C(=O)O)cc2c1-c1ccccc1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC(=O)Cl.Cl.N#Cc1cnn(-c2ccccc2)c1N.c1ccncc1>>CCCC(=O)Nc1c(C#N)cnn1-c1ccccc1",
        "output": "527"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1=CCCCC1.CC(C)OC(C)C.CCO.Cn1ccc2ccc(OCc3ccccc3)cc21.[Pd]>>Cn1ccc2ccc(O)cc21",
        "output": "23"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)C1CCN(S(=O)(=O)c2cccs2)CC1.Cl.O.[K+].[OH-]>>O=C(O)C1CCN(S(=O)(=O)c2cccs2)CC1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1CN.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.O=C(O)c1ccccc1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCC[C@H]1CNC(=O)c1ccccc1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C1CCOC1.CC(C)(C)[Si](C)(C)Oc1ccc(-n2cnc3ccc(C#N)cc32)cc1.CCCC[N+](CCCC)(CCCC)CCCC.O.[F-]>>N#Cc1ccc2ncn(-c3ccc(O)cc3)c2c1",
        "output": "754"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)CC1.CCOC(=O)N=NC(=O)OCC.Cc1ccc(Cl)c(O)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1ccc(Cl)c(OC2CCN(C(=O)OC(C)(C)C)CC2)c1",
        "output": "846"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.CN1CCCCC1CCCl.COC(=O)c1c[nH]c2ccccc12.Cl>>COC(=O)c1cn(CCC2CCCCN2C)c2ccccc12",
        "output": "42"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.N[C@H]1CCCN[C@H]1c1ccccc1.O=C(Cl)OCc1ccccc1>>O=C(N[C@H]1CCCN[C@H]1c1ccccc1)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccccc1-c1c2ccc(=O)cc-2oc2cc(O)ccc12.O=[N+]([O-])c1ccccc1CBr>>Cc1ccccc1-c1c2ccc(=O)cc-2oc2cc(OCc3ccccc3[N+](=O)[O-])ccc12",
        "output": "127"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc2ncc(F)c(CC(C)(O)C34CCC(NC(=O)OC(C)(C)C)(CC3)CO4)c2n1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc2ncc(F)c(CC(C)(O)C34CCC(N)(CC3)CO4)c2n1",
        "output": "538"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCCC(N)C1.CC(C)(C)OC(=O)N1CC[C@@H](N)C1.CCCCc1nc2ccccn2c(=O)c1-c1ccc(Cl)cc1.CCc1nc2ccccn2c(=O)c1-c1ccc(Cl)cc1>>CCc1nc2ccccn2c(=O)c1-c1ccc(N[C@@H]2CCN(C(=O)OC(C)(C)C)C2)cc1",
        "output": "304"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrP(Br)Br.CN(C)C=O.Cc1ccccc1-c1csc2ccc(CO)cc12.ClCCl.O>>Cc1ccccc1-c1csc2ccc(CBr)cc12",
        "output": "300"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(O)Cn1ccc(N)n1.O=C(O)C(CC1CCCC1)n1ncc(Oc2ccccc2C(=O)N2CCCC2)cc1=O>>CC(C)(O)Cn1ccc(NC(=O)C(CC2CCCC2)n2ncc(Oc3ccccc3C(=O)N3CCCC3)cc2=O)n1",
        "output": "795"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCc2oc3cc(-n4ccc(-c5ccc(C(F)(F)F)cn5)cc4=O)ccc3c2C1.CCOCC.CO.Cl.O=C([O-])O.[Na+]>>O=c1cc(-c2ccc(C(F)(F)F)cn2)ccn1-c1ccc2c3c(oc2c1)CCNC3",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CCO.CN.Clc1nc2ccccc2[nH]1>>CNc1nc2ccccc2[nH]1",
        "output": "544"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN=C=NCCCN(C)C.Cl.ClC(Cl)Cl.O=C(O)c1cccc(C(F)(F)F)c1F.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCN(C(=O)c2cccc(C(F)(F)F)c2F)CC1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCCC.CCCCCCc1cc2c(cc1Br)C(C)(C)CCC2(C)C.Cl.O=C=O.[Li]C(C)(C)C>>CCCCCCc1cc2c(cc1C(=O)O)C(C)(C)CCC2(C)C",
        "output": "654"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(c1ccccc1-c1ccccc1)C(C)(C)C.N#Cc1ccc(Cl)cc1.OB(O)c1ccccc1.[F-].[K+].[Pd+2]>>N#Cc1ccc(-c2ccccc2)cc1",
        "output": "892"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)c1ncnc2ccc(C=O)cc12.O=C1CSC(=O)N1>>CN(C)c1ncnc2ccc(C=C3SC(=O)NC3=O)cc12",
        "output": "761"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C=CCBr.CCCC[N+](CCCC)(CCCC)CCCC.COC(=O)C1CNCCc2c1[nH]c1ccccc21.O=C([O-])[O-].[Br-].[K+].[K+]>>C=CCN1CCc2c([nH]c3ccccc23)C(C(=O)OC)C1",
        "output": "252"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NC1CC(=O)N(c2ccc3c(c2)NC(=O)CO3)C1.ClCCl.O=C(O)C(F)(F)F>>NC1CC(=O)N(c2ccc3c(c2)NC(=O)CO3)C1",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CCS.CO.COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2ccc(OCC(O)CN3CCCC3)cc2)cc1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(c1ccc(OCC(O)CN2CCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12",
        "output": "20"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)CCc1cccc(C(=O)O)c1.NCc1ccccc1>>CC(C)CCc1cccc(C(=O)NCc2ccccc2)c1",
        "output": "753"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CNC.Cn1c(Nc2nc3ccc(Cl)cc3s2)nc2cc(C(=O)NCC(=O)N3CCC[C@H]3C(=O)O)ccc21.F[P-](F)(F)(F)(F)F>>CN(C)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccc2c(c1)nc(Nc1nc3ccc(Cl)cc3s1)n2C",
        "output": "685"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OCc1c(-c2cc(Nc3ccc(N4C[C@@H](C)N(C5COC5)C[C@@H]4C)cn3)c(=O)n(C)c2)cc(F)cc1N1CCn2c(cc3c2CCCC3)C1=O.[Li+].[OH-]>>C[C@@H]1CN(c2ccc(Nc3cc(-c4cc(F)cc(N5CCn6c(cc7c6CCCC7)C5=O)c4CO)cn(C)c3=O)nc2)[C@@H](C)CN1C1COC1",
        "output": "497"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cccc(S(=O)(=O)N2CC(C(=O)O)N(c3ccccc3)C2=O)c1.Cc1cccnc1N1CCNCC1>>COc1cccc(S(=O)(=O)N2CC(C(=O)N3CCN(c4ncccc4C)CC3)N(c3ccccc3)C2=O)c1",
        "output": "685"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCOc1ccc(S(=O)(=O)C2(C(=O)OCC)CCN(CCCC)CC2)cc1.CO.[Na+].[OH-]>>CCCCOc1ccc(S(=O)(=O)C2(C(=O)O)CCN(CCCC)CC2)cc1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)c1ccncc1.COc1ccc(Sc2cc(C)c(-c3csc(N)n3)c(Cl)c2)cc1.Cl.O=C(Cl)c1ccncc1>>COc1ccc(Sc2cc(C)c(-c3csc(NC(=O)c4ccncc4)n3)c(Cl)c2)cc1",
        "output": "673"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])c(Oc3ccccc3)c2)CC1.CCO.[Pd]>>CC(C)(C)OC(=O)N1CCN(c2ccc(N)c(Oc3ccccc3)c2)CC1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.OC1CCCC1.[Na+]>>COc1cc2nccc(Oc3ccc(NC(=O)OC4CCCC4)c(C)c3C)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cl.NO.O.O=Cc1ccc(Br)cc1F>>ON=Cc1ccc(Br)cc1F",
        "output": "30"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(C)=O.Cl.O.O=[N+]([O-])c1ccc(Cl)c(F)c1CCO.[Fe]>>Nc1ccc(Cl)c(F)c1CCO",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.Cc1csc(NC(=O)Oc2ccccc2)n1.Nc1ccc(F)c(Br)c1>>Cc1csc(NC(=O)Nc2ccc(F)c(Br)c2)n1",
        "output": "948"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(O)c(C)cc1N.Fc1cnc(Cl)nc1Nc1ccc2c(c1)OCCO2>>Cc1cc(Nc2ncc(F)c(Nc3ccc4c(c3)OCCO4)n2)c(C)cc1O",
        "output": "808"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)c1cc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)ccc1OCCN1CCC(C)CC1.CCO.O.[BH4-].[Na+]>>CC1CCN(CCOc2ccc(C#Cc3ccc(-c4ccc(Cl)cc4)cn3)cc2C(C)O)CC1",
        "output": "24"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN.Cl.ClCCl.O=C(Cl)c1ccc(C(=C2CC3CCC(C2)N3CCc2ccccc2)c2ccccc2)cc1.[Na+].[OH-]>>CCNC(=O)c1ccc(C(=C2CC3CCC(C2)N3CCc2ccccc2)c2ccccc2)cc1",
        "output": "271"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)Cn1c2c(c3cc(Cl)c(Cl)cc31)CCN(C(=O)OC(C)(C)C)CC2.CCOC(C)=O.O.[BH4-].[Li+].[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCc2c(n(CCO)c3cc(Cl)c(Cl)cc23)CC1",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(O)CCCc1cccc(Cl)c1.O=S(Cl)Cl>>O=C1CCCc2cc(Cl)ccc21",
        "output": "274"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1C[C@@H]2CCN[C@@H]2C1.O=C(Nc1cc(F)cc(F)c1)c1cncc(Br)c1>>CC(C)(C)OC(=O)N1C[C@@H]2CCN(c3cncc(C(=O)Nc4cc(F)cc(F)c4)c3)[C@@H]2C1",
        "output": "597"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CNOC.Cl.Cl.O.O=C(O)c1cc(Br)cc2ccccc12.On1nnc2ccccc21>>CON(C)C(=O)c1cc(Br)cc2ccccc12",
        "output": "828"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.C[C@@H]1CN(c2ccc(S(=O)(=O)Nc3ncns3)cc2)CCN1.Cl.F[P-](F)(F)(F)(F)F.Nc1ncns1.O=C(O)Cn1ccc2cccc(Cl)c21.O=C([O-])O.[Na+]>>C[C@@H]1CN(c2ccc(S(=O)(=O)Nc3ncns3)cc2)CCN1C(=O)Cn1ccc2cccc(Cl)c21",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COc1ccc([N+](=O)[O-])cc1-c1cccc(CNC(C)C)c1.[Pd]>>COc1ccc(N)cc1-c1cccc(CNC(C)C)c1",
        "output": "202"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCCC12CCC(=O)C=C1c1c(cc(OCC(N)=O)c(Cl)c1Cl)C2=O.ClCCl.c1ccncc1>>CCCC12CCC(=O)C=C1c1c(cc(OCC#N)c(Cl)c1Cl)C2=O",
        "output": "172"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N(C)C.CCOC(C)=O.Cc1noc2cc(O)ccc12.N#Cc1cc(F)ccc1F.O=C([O-])[O-].[K+].[K+]>>Cc1noc2cc(Oc3ccc(F)cc3C#N)ccc12",
        "output": "564"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1CCCN(c2ccccc2)C1=O.CO.[Na+].[OH-]>>O=C(O)C1CCCN(c2ccccc2)C1=O",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)N1C2CCC(C2)C1C(=O)O.CC(C)(C)OC(=O)N1CCCC1C(=O)OCC(=O)c1ccc2c(c1)COCc1cc(C(=O)CBr)ccc1-2.CCN(CC)CC.CN(C)C=O>>CC(C)(C)OC(=O)N1CCCC1C(=O)OCC(=O)c1ccc2c(c1)COCc1cc(C(=O)COC(=O)C3C4CCC(C4)N3C(=O)OC(C)(C)C)ccc1-2",
        "output": "523"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1cn2c(n1)CNCC2.O=C(O)c1cc2ncc(Cl)cn2n1>>CCOC(=O)c1cn2c(n1)CN(C(=O)c1cc3ncc(Cl)cn3n1)CC2",
        "output": "663"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CN1C(=O)C2C3C=CC(CC3)C2(c2ccc(Cl)c(Cl)c2)C1=O.Cl.O=[Pt]>>CN1C(=O)C2C3CCC(CC3)C2(c2ccc(Cl)c(Cl)c2)C1=O",
        "output": "143"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1ccc(O)c(Br)c1.CCN(CC)CC.COCCOCCl.ClCCl.O>>COCCOCOc1ccc(C(C)(C)C)cc1Br",
        "output": "375"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)c1ccc(F)c(Br)c1.CCO.Cl.NO.c1ccncc1>>CC(=NO)c1ccc(F)c(Br)c1",
        "output": "212"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.C[O-].Nc1nc(Cl)ccc1[N+](=O)[O-].[Na+]>>COc1ccc([N+](=O)[O-])c(N)n1",
        "output": "433"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCCCC.CCCCCCCC(=O)[O-].CCCCCCCCO.Clc1cc(Br)cnc1Br.[Li+].[Li]CCCC>>CCCCCCCCOc1ncc(Br)cc1Cl",
        "output": "551"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)CC(N)CC(C)(C)N1.CN(C)C=O.Cc1ccc(C(=O)Nc2ccc(C)c(-c3nc(S(C)(=O)=O)nc4c3CNC(=O)N4c3c(F)cccc3F)c2)cc1F>>Cc1ccc(C(=O)Nc2ccc(C)c(-c3nc(NC4CC(C)(C)NC(C)(C)C4)nc4c3CNC(=O)N4c3c(F)cccc3F)c2)cc1F",
        "output": "629"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC1CCCN1.O[C@@H]1CC[C@@H](c2ccc(OCCCCl)cc2)CC1.[Na]>>CC1CCCN1CCCOc1ccc([C@@H]2CC[C@@H](O)CC2)cc1",
        "output": "138"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1c(F)c(N)cc2oc(=O)[nH]c12.O=Cc1ccccc1>>Cc1c(F)c(NCc2ccccc2)cc2oc(=O)[nH]c12",
        "output": "359"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)c1cc(Cl)ncn1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN1CCCC1=O.NCc1cnc2[nH]c(C(F)(F)F)cc2c1>>CC(C)c1cc(NCc2cnc3[nH]c(C(F)(F)F)cc3c2)ncn1",
        "output": "166"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc2cc(C(=O)O)c(C(=O)O)nc2cc1OC.I>>O=C(O)c1cc2cc(O)c(O)cc2nc1C(=O)O",
        "output": "19"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=C(CC(C)C)C(=O)OCC.CC#N.CCO.CCOCC.[Li+].[OH-]>>C=C(CC(C)C)C(=O)O",
        "output": "122"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.C[O-].Nc1nc(Cl)c2c(n1)OCCC2.[Na+]>>COc1nc(N)nc2c1CCCO2",
        "output": "461"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.N[C@H]1CC2(CC[C@@H]1O)OCCO2.O=C([O-])O.O=C1CCN(C(=O)OCc2ccccc2)CC1.[Na+].[Na+]>>O=C(OCc1ccccc1)N1CCC(N[C@H]2CC3(CC[C@@H]2O)OCCO3)CC1",
        "output": "236"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1cc(Br)cc2cnc(Cl)nc12.ClCCl>>Oc1cc(Br)cc2cnc(Cl)nc12",
        "output": "424"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCc1cc2ccccc2n1S(=O)(=O)c1ccccc1.[Na+].[OH-]>>CCc1cc2ccccc2[nH]1",
        "output": "771"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CNCCCN(C)C(=O)OC(C)(C)C.Cl.O=C(O)c1ccc2nc(Br)sc2c1>>CN(CCCN(C)C(=O)c1ccc2nc(Br)sc2c1)C(=O)OC(C)(C)C",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCCN(C)C.CN(C(=O)OC(C)(C)C)[C@H](Cc1ccccc1)C(=O)O.CN(C)C=O.Cl.NCCCO.O.O=S(=O)([O-])O.On1nnc2ccccc21.[Na+]>>CN(C(=O)OC(C)(C)C)[C@H](Cc1ccccc1)C(=O)NCCCO",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C[Si](C)(C)CCOCn1nc(-c2nnn[nH]2)c2cc(NC(=O)C3CCN(CC(=O)N4CCN(c5ccc(-c6ncccn6)cc5)CC4)C3)ccc21.ClCCl.O=C(O)C(F)(F)F>>O=C(Nc1ccc2[nH]nc(-c3nnn[nH]3)c2c1)C1CCN(CC(=O)N2CCN(c3ccc(-c4ncccn4)cc3)CC2)C1",
        "output": "813"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.CCN1C(=O)C(C)(C)c2cc3nc(-c4n[nH]c5ccc(N)cc45)[nH]c3cc21.c1ccncc1>>CCN1C(=O)C(C)(C)c2cc3nc(-c4n[nH]c5ccc(NC(C)=O)cc45)[nH]c3cc21",
        "output": "6"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)[Si](C)(C)O[C@H]1CN(Cc2ccccc2)C[C@H]1N.ClCCl>>CC(C)(C)OC(=O)N[C@@H]1CN(Cc2ccccc2)C[C@@H]1O[Si](C)(C)C(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=S(=O)(O)O.O=S1(=O)c2ccccc2-c2ccc(F)cc21.O=[N+]([O-])O>>O=[N+]([O-])c1ccc2c(c1)S(=O)(=O)c1cc(F)ccc1-2",
        "output": "21"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.Cc1nc(N)ccc1C#N.[Ni]>>Cc1nc(N)ccc1CN",
        "output": "560"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CC(=O)N(C)C.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.C[C@@H](Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)C(=O)O.F[P-](F)(F)(F)(F)F.O>>C[C@@H](Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)C(=O)N1CCOCC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCO.N#Cc1ccc(SC(F)(F)F)cc1.O.[Cl-].[NH3+]O>>NC(=NO)c1ccc(SC(F)(F)F)cc1",
        "output": "400"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)c1cc(C(=O)Nc2ccc([N+](=O)[O-])cc2)cc(C(C)(C)C)c1O.CCO.ClCCl.[H][H].[Pd]>>CC(C)(C)c1cc(C(=O)Nc2ccc(N)cc2)cc(C(C)(C)C)c1O",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)CCCCc1cc(-c2ccccc2NC(C)=O)on1.Cl>>CC(=O)Nc1ccccc1-c1cc(CCCCC(=O)O)no1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(Cc2ccc(C(=O)Nc3ccc(Cl)cc3N3CCN(CCC(F)(F)F)CC3)c(F)c2F)C(CC(=O)O)C1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)CC1CNCCN1Cc1ccc(C(=O)Nc2ccc(Cl)cc2N2CCN(CCC(F)(F)F)CC2)c(F)c1F",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CS(=O)(=O)OCCCC#Cc1ccc(C#N)cc1.O.[N-]=[N+]=[N-].[Na+]>>N#Cc1ccc(C#CCCCN=[N+]=[N-])cc1",
        "output": "322"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.N#CCCc1cnc(N)cn1.O=C1CCC(=O)N1Br>>N#CCCc1cnc(N)c(Br)n1",
        "output": "665"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCCN(C(=O)Nc2cc(C(C)(C)C)on2)CC1.Cl.ClCCl>>CC(C)(C)c1cc(NC(=O)N2CCCNCC2)no1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.CCCCCCCC(=O)N(C)CCC(=O)O.O=S(=O)(O)O>>CCCCCCCC(=O)N(C)CCC(=O)OC(C)C",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#C[C@]1(O)CCN(C)C1=O.CCOC(=O)c1nn(-c2cccc(Br)c2)c2c1CN(S(C)(=O)=O)CC2>>CCOC(=O)c1nn(-c2cccc(C#C[C@]3(O)CCN(C)C3=O)c2)c2c1CN(S(C)(=O)=O)CC2",
        "output": "659"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Cc1cc(Cl)c2cccc(O)c2n1.OCc1ccccc1F.[H-].[Na+]>>Cc1cc(OCc2ccccc2F)c2cccc(O)c2n1",
        "output": "651"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Fc1ccc(SCCCCl)cc1.O=C(OO)c1cccc(Cl)c1>>O=S(CCCCl)c1ccc(F)cc1",
        "output": "500"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOc1ccc(C(=O)Nc2cc(F)c(C(=O)OCc3ccccc3)c(F)c2)cc1C(F)(F)F.CO.[Pd]>>CCOc1ccc(C(=O)Nc2cc(F)c(C(=O)O)c(F)c2)cc1C(F)(F)F",
        "output": "290"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)[C@H](C=C(Cl)Cl)[C@@H]1C(=O)Cl.Cc1ccccc1.N#CC(O)c1cccc(Oc2ccccc2)c1.c1ccncc1>>CC1(C)[C@H](C=C(Cl)Cl)[C@@H]1C(=O)OC(C#N)c1cccc(Oc2ccccc2)c1",
        "output": "126"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.COc1cc(N)ccc1N1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(Cl)c1ccc(C2CCCCC2)cc1>>COc1cc(NC(=O)c2ccc(C3CCCCC3)cc2)ccc1N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "11"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCCCC(CC)C(=O)O.CN(C)c1ccncc1.ClCCl.OCCCCCCCCCO>>CCCCC(CC)C(=O)OCCCCCCCCCO",
        "output": "47"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.NCC1(c2ccc([N+](=O)[O-])cc2)CCOCC1>>CC(C)(C)OC(=O)NCC1(c2ccc([N+](=O)[O-])cc2)CCOCC1",
        "output": "631"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(=O)(=O)c1cccc(N)c1.Cc1cc(-c2ccc(Cl)cc2)nc2c(C(=O)O)cnn12>>Cc1cc(-c2ccc(Cl)cc2)nc2c(C(=O)Nc3cccc(S(C)(=O)=O)c3)cnn12",
        "output": "969"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCOC(=O)C(Cc1cccc(O)c1)OC(C)C.CN(C)c1ccncc1.ClCCl.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)C(Cc1cccc(OS(=O)(=O)C(F)(F)F)c1)OC(C)C",
        "output": "843"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCN(CC)CC.CS(=O)(=O)Cl.NCCON1C(=O)c2ccccc2C1=O>>CS(=O)(=O)NCCON1C(=O)c2ccccc2C1=O",
        "output": "493"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COc1cc2ncnc(Oc3ccc(N)c([N+](=O)[O-])c3)c2cc1OC.ClC(Cl)Cl.NCCN1CCCCC1.O.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2ncnc(Oc3ccc(NC(=O)NCCN4CCCCC4)c([N+](=O)[O-])c3)c2cc1OC",
        "output": "913"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(CCCCCl)c1ccc(Cl)cc1.O=C(Nc1cccc(C2CCNCC2)c1)C1CC1>>O=C(CCCCN1CCC(c2cccc(NC(=O)C3CC3)c2)CC1)c1ccc(Cl)cc1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CNC.COC(=O)C(CCO)N1CCN(C(=O)/C=C/c2ccc(Cl)c(Cl)c2)CCC1=O.O=C1OCCC1N1CCN(C(=O)/C=C/c2ccc(Cl)c(Cl)c2)CCC1=O>>CN(C)C(=O)C(CCO)N1CCN(C(=O)/C=C/c2ccc(Cl)c(Cl)c2)CCC1=O",
        "output": "227"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "B.C1CCOC1.C1CCOC1.CCOCC.O.O=C(O)c1c(F)c(F)c(F)c(-c2ccccc2)c1F>>OCc1c(F)c(F)c(F)c(-c2ccccc2)c1F",
        "output": "72"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrBr.CSc1ccccc1.ClCCl.O.[Al+3].[Cl-].[Cl-].[Cl-]>>CSc1ccc(Br)cc1",
        "output": "98"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)n1nc(N)c2ccc(OCCOCc3ccccc3)cc21.CCN(C(C)C)C(C)C.CN1CCN(c2ccc(C(=O)Cl)cc2)CC1.CN1CCN(c2ccc(C(=O)O)cc2)CC1.Cl>>CN1CCN(c2ccc(C(=O)Nc3nn(C(=O)OC(C)(C)C)c4cc(OCCOCc5ccccc5)ccc34)cc2)CC1",
        "output": "917"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCC.CCOC(C)=O.CO.C[C@@H]1CCN(Cc2ccccc2)C[C@@H]1Nc1c(C=O)cnc2c1ccn2COCC[Si](C)(C)C.[BH4-].[Na+]>>C[C@@H]1CCN(Cc2ccccc2)C[C@@H]1Nc1c(CO)cnc2c1ccn2COCC[Si](C)(C)C",
        "output": "476"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(=O)N1CCNCC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(C=O)ccc21.O.O=C([O-])[O-].[Na+].[Na+].[Na+]>>CC(=O)N1CCN(Cc2ccc3c(c2)cc(-c2ccc(Cl)c4c2C(=O)NC4)n3C(=O)OC(C)(C)C)CC1",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CCCCCCCCCc1cc(C)c(O)c(C=O)c1.CO.NO.O=S(=O)(O)O.[Na+]>>CCCCCCCCCc1cc(C)c(O)c(C=NO)c1",
        "output": "30"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1C2CC3CC1CC(CO)(C3)C2.ClCCl.O=C(O)C(F)(F)F>>OCC12CC3CC(C1)NC(C3)C2",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.C[C@H]1CN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CCN1.Cc1cncc(C(=O)O)c1.F[P-](F)(F)(F)(F)F.O.On1nnc2ccccc21>>Cc1cncc(C(=O)N2CCN(S(=O)(=O)c3ccc(C(F)(F)F)cc3)C[C@@H]2C)c1",
        "output": "256"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.COC(=O)Cc1cc(Br)c(Oc2ccc(OC)c(C(C)C)c2)c(Br)c1.ClCCl.Cl[Ti](Cl)(Cl)Cl>>COC(=O)Cc1cc(Br)c(Oc2cc(C(C)C)c(OC)cc2C(C)=O)c(Br)c1",
        "output": "31"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNCCN1.CCOc1nc(Cl)nc2c1sc1nc(-c3ccc(OC)c(OC)c3)cc(C)c12.Cc1ccccc1>>CCOc1nc(N2CCNCC2)nc2c1sc1nc(-c3ccc(OC)c(OC)c3)cc(C)c12",
        "output": "36"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "N#Cc1c([N+](=O)[O-])cccc1[N+](=O)[O-].OCCn1cccn1>>N#Cc1c(OCCn2cccn2)cccc1[N+](=O)[O-]",
        "output": "499"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.Fc1ccc(Br)cn1.O[C@H]1CCNC1>>O[C@H]1CCN(c2ccc(Br)cn2)C1",
        "output": "756"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCP(CCCC)CCCC.CCN(C(C)C)C(C)C.CCOC(C)=O.COC(=O)C1=C(c2ccc(CCCO)cc2)CCN(C(=O)OC(C)(C)C)C1.Cc1ccccc1.Oc1c(F)ccc(F)c1F>>COC(=O)C1=C(c2ccc(CCCOc3c(F)ccc(F)c3F)cc2)CCN(C(=O)OC(C)(C)C)C1",
        "output": "550"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN1C(=O)C(NC(=O)C(F)(F)F)CCc2c1ccc(N)c2OC.CS(=O)(=O)N[C@@H]1CCCC[C@H]1Nc1nc(Cl)ncc1Cl>>CCN1C(=O)C(NC(=O)C(F)(F)F)CCc2c1ccc(Nc1ncc(Cl)c(N[C@@H]3CCCC[C@H]3NS(C)(=O)=O)n1)c2OC",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CCCBr.Cc1c(CC(N)=O)c2cc(O)ccc2n1C1CCCCC1.[H-].[Na+]>>CCOC(=O)CCCOc1ccc2c(c1)c(CC(N)=O)c(C)n2C1CCCCC1",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.Nc1cc(Br)cnc1Br.O=S(=O)(Cl)c1ccc(Oc2ccc(Cl)cc2)cc1.c1ccncc1>>O=S(=O)(Nc1cc(Br)cnc1Br)c1ccc(Oc2ccc(Cl)cc2)cc1",
        "output": "554"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cc1cc2c(cc1C(=O)N1Cc3ccccc3C1)[nH]c(=O)c1nnc([C@@H]3CCC[C@@H]3OCc3ccccc3)n12.[Pd]>>Cc1cc2c(cc1C(=O)N1Cc3ccccc3C1)[nH]c(=O)c1nnc([C@@H]3CCC[C@@H]3O)n12",
        "output": "178"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CN(Cc1ccc([N+](=O)[O-])cc1)Cc1nc(-c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cs1.Cl.Cl[Sn]Cl.[Na+].[OH-].[Zn]>>CN(Cc1ccc(N)cc1)Cc1nc(-c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cs1",
        "output": "507"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)CCc1cc(Cl)c(-c2nc3ccc(-c4nnc(-c5ccc(Cl)cc5)o4)cc3[nH]2)c(Cl)c1.COc1ccccc1.Cl>>O=C(O)CCc1cc(Cl)c(-c2nc3ccc(-c4nnc(-c5ccc(Cl)cc5)o4)cc3[nH]2)c(Cl)c1",
        "output": "278"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(C)=O.Cc1cnc(=O)[nH]c1.ClCCCCBr.O=C([O-])[O-].[K+].[K+]>>Cc1cnc(=O)n(CCCCCl)c1",
        "output": "327"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#Cc1cccnc1N.C1CCOC1.CCN(CC)CC.ON=C(Cl)Cc1ccc(OCc2ccccc2)nc1>>Nc1ncccc1-c1cc(Cc2ccc(OCc3ccccc3)nc2)no1",
        "output": "976"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC=O.CN(C)C=O.O=C(Cc1cc(Nc2ncnc3cc(OCCCNCCCO)ccc23)n[nH]1)Nc1cccc(F)c1>>CCN(CCCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1",
        "output": "484"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.OCCc1ccc(F)cc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCc1ccc(F)cc1",
        "output": "193"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCNC/C=C\\c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)OC)OCC1CC21.O.O.[Li+].[OH-]>>CCNC/C=C\\c1cc(F)ccc1S(=O)(=O)Nc1ccc2c(c1C(=O)O)OCC1CC21",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNCC1.CCO.Cc1c(C=O)[nH]c2c1C(=O)N(C[C@@H](O)CN1CCOCC1)CC2.O=C(CO)Nc1cc2c(cc1F)CC(=O)N2>>Cc1c(/C=C2\\C(=O)Nc3cc(NC(=O)CO)c(F)cc32)[nH]c2c1C(=O)N(C[C@@H](O)CN1CCOCC1)CC2",
        "output": "911"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCN(CC)CC.CN(C)C=O.C[NH3+].ClCCl.O=C(O)c1cc(O)cc(F)c1.[Cl-]>>CNC(=O)c1cc(O)cc(F)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cc1ccccc1.CC(=O)Cc1ccccc1C.CCCCCC(CCCC(C(C)=O)c1ccccc1C)OCc1ccccc1.CCCCCC(CCCC(CCCCCCC(=O)O)(C(C)=O)c1ccccc1C)OCc1ccccc1.CCCCCC(CCCC(CCCCCCC(=O)OCC)(C(C)=O)c1ccccc1C)OCc1ccccc1.CCCCCC(O)CCCC(CCCCCC(C(=O)O)c1ccccc1C)C(C)=O>>CCCCCC(O)CCCC(CCCCCCC(=O)O)(C(C)=O)c1ccccc1C",
        "output": "178"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)C1CC(O[Si](C)(C)C(C)(C)C)C1>>CC(C)(C)[Si](C)(C)OC1CC(CO)C1",
        "output": "343"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N(CCCN2CCOCC2)C2CCN(C(=O)OC(C)(C)C)CC2)n1.ClCCl.O=C(O)C(F)(F)F>>COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N(CCCN2CCOCC2)C2CCNCC2)n1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)CCCC(=O)c1ccc(O)c(CCC(=O)OC)n1.COc1ccc(/C=C/CCCCBr)cc1>>COC(=O)CCCC(=O)c1ccc(OCCCC/C=C/c2ccc(OC)cc2)c(CCC(=O)OC)n1",
        "output": "608"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.N.N#Cc1cc(NC(=O)C2CCc3ccc(Oc4ccnc(C(=O)N5CCCC5)c4)cc3C2)cc(C(F)(F)F)c1.[Ni]>>NCc1cc(NC(=O)C2CCc3ccc(Oc4ccnc(C(=O)N5CCCC5)c4)cc3C2)cc(C(F)(F)F)c1",
        "output": "175"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCn1nc(C)c2c(Cl)c(CO)cnc21.O=S(Cl)Cl>>CCn1nc(C)c2c(Cl)c(CCl)cnc21",
        "output": "477"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cnc(-c2ccc(S(C)(=O)=O)c(F)c2)o1.[Na+].[OH-]>>CS(=O)(=O)c1ccc(-c2ncc(C(=O)O)o2)cc1F",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)[C@H](F)CN(Cc1ccccc1)Cc1ccccc1.Cl.O.[Li+].[OH-]>>O=C(O)[C@H](F)CN(Cc1ccccc1)Cc1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CI.COC(=O)c1c(Cl)ccc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c1C.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1c(Cl)ccc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c1C",
        "output": "570"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.CC[Si](C)(CC)OC(CC(=O)OC(C)(C)C)C(C)(C)C(=O)C(C)C(O)C(C)COCc1ccccc1.Cc1cccc(C)n1.ClCCl.O=C([O-])O.[Na+]>>CC[Si](C)(CC)OC(CC(=O)OC(C)(C)C)C(C)(C)C(=O)C(C)C(O[Si](C)(C)C(C)(C)C)C(C)COCc1ccccc1",
        "output": "839"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCOC(C)=O.O=C1CCC(=O)N1Br.O=Cc1cccc(F)c1O>>O=Cc1cc(Br)cc(F)c1O",
        "output": "4"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)CNC(=O)c1c(O)c(-c2csc3ccccc23)cc2nccnc12.[Na+].[OH-]>>O=C(O)CNC(=O)c1c(O)c(-c2csc3ccccc23)cc2nccnc12",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)c1ccc(O)c(F)c1.CN(C)c1ccccn1.Cc1cccc(C)n1.ClC(Cl)Cl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)c1ccc(OS(=O)(=O)C(F)(F)F)c(F)c1",
        "output": "731"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Cl.Clc1csc2ncnc(Cl)c12.NCCc1cccc(O)c1.O>>Oc1cccc(CCNc2ncnc3scc(Cl)c23)c1",
        "output": "723"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cccc(C)c1N1CCN(C)CC1.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+].[Na+].[OH-]>>COc1ccc([N+](=O)[O-])c(C)c1N1CCN(C)CC1",
        "output": "21"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.Cc1ccc2c(Cl)cc(Cl)c(O)c2n1.O=[Se]=O>>O=Cc1ccc2c(Cl)cc(Cl)c(O)c2n1",
        "output": "619"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.Cc1cccc(C)c1C=O.ClCCCl.[Na+].c1ccc2ncc(Nc3ncnc4c3CNC4)cc2c1>>Cc1cccc(C)c1CN1Cc2ncnc(Nc3cnc4ccccc4c3)c2C1",
        "output": "567"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCS(=O)(=O)Nc1ccc(Cl)c(C(=O)OCc2ccccc2)c1F.Cl.O.[K+].[OH-]>>CCCS(=O)(=O)Nc1ccc(Cl)c(C(=O)O)c1F",
        "output": "290"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C[C@@H](N)CC1CCCCC1)C(=O)OCC[Si](C)(C)C.ClCCCl.ClCCl.O=Cc1cccc(C(=O)O)c1>>CN(C[C@H](CC1CCCCC1)NC(=O)c1cccc(C=O)c1)C(=O)OCC[Si](C)(C)C",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)O.O=[N+]([O-])c1ccc(F)cc1[N+](=O)[O-].[H-].[Na+]>>CC(C)Oc1ccc([N+](=O)[O-])c([N+](=O)[O-])c1",
        "output": "485"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cnc(Cl)c(Cl)c1.CCOC(C)=O.CN(C)C=O.NCCOc1ccccc1.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cnc(NCCOc2ccccc2)c(Cl)c1",
        "output": "70"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1ccc(Oc2c(Cl)cc(C=C3SC(=O)NC3=O)cc2Cl)cc1C(C)C.ClCCl>>CC(C)c1cc(Oc2c(Cl)cc(C=C3SC(=O)NC3=O)cc2Cl)ccc1O",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.Cc1cc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)cc(C)c1OCc1ccccc1.ClCCl>>Cc1cc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)cc(C)c1O",
        "output": "23"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C(O)c1cn(C2CC2)c2c(F)c(F)c(F)c(F)c2c1=O.O=CN1CCNCC1.c1ccncc1>>O=CN1CCN(c2c(F)c(F)c3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)CC1",
        "output": "676"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.COC(=O)Cc1cn(C[C@@H](CCO)NS(=O)(=O)c2ccc(F)cc2)c2ncccc12.ClCCl>>COC(=O)Cc1cn(C[C@@H](CC=O)NS(=O)(=O)c2ccc(F)cc2)c2ncccc12",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCNc1nc(N2CCN(Cc3ccccc3)CC2)ncc1C(=O)OCC.CCO.O.[K+].[OH-]>>CCNc1nc(N2CCN(Cc3ccccc3)CC2)ncc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.Nc1ncccc1OCc1c(Cl)ccc(F)c1Cl.O=C1CCC(=O)N1Br>>Nc1ncc(Br)cc1OCc1c(Cl)ccc(F)c1Cl",
        "output": "518"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.[N-]=[N+]=NCCOCCOCCO>>Cc1ccc(S(=O)(=O)OCCOCCOCCN=[N+]=[N-])cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1cc(N)c(C)cn1.[Na+].[OH-]>>Cc1cnc(C(=O)O)cc1N",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)CN(c1ccc2c(c1)nc(COc1ccc(C(=N)N)cc1)n2C)S(=O)(=O)c1ccccc1.[Na+].[OH-]>>Cn1c(COc2ccc(C(=N)N)cc2)nc2cc(N(CC(=O)O)S(=O)(=O)c3ccccc3)ccc21",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cc(F)c(-n2nc(C(F)(F)F)nc2NC(=O)C(F)(F)F)cc1C(SC(c1cc(-n2nc(C(F)(F)F)nc2NC(=O)C(F)(F)F)c(F)cc1C)C(F)(F)F)C(F)(F)F.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>Cc1cc(F)c(-n2nc(C(F)(F)F)nc2NC(=O)C(F)(F)F)cc1C(S(=O)C(c1cc(-n2nc(C(F)(F)F)nc2NC(=O)C(F)(F)F)c(F)cc1C)C(F)(F)F)C(F)(F)F",
        "output": "13"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(Cl)cc1CN.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CN1CCOCC1.F[P-](F)(F)(F)(F)F.O=C(O)[C@@H]1CCCN1C(=O)C1(O)c2ccccc2-c2ccccc21>>CC(C)(C)OC(=O)NCc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1C(=O)C1(O)c2ccccc2-c2ccccc21",
        "output": "797"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CON(C)C(=O)C1CCN(C(=O)OCc2ccccc2)CC1.[C].[Pd]>>CON(C)C(=O)C1CCNCC1",
        "output": "428"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=Cc1ccc(N(C)S(C)(=O)=O)c(Nc2nc(Cl)ncc2Cl)c1.COCCO.COc1cc(N2CCN(C)CC2)c(Br)cc1N.CS(=O)(=O)O>>C=Cc1ccc(N(C)S(C)(=O)=O)c(Nc2nc(Nc3cc(Br)c(N4CCN(C)CC4)cc3OC)ncc2Cl)c1",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1c(Cc2ccc(-n3ccc(C4CC4)n3)cc2)c(OC(F)F)nc2c(Cl)ccc(OCC(=O)OC(C)(C)C)c12.ClCCl.O=C(O)C(F)(F)F>>Cc1c(Cc2ccc(-n3ccc(C4CC4)n3)cc2)c(OC(F)F)nc2c(Cl)ccc(OCC(=O)O)c12",
        "output": "278"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC1(C)OB(c2ccc3occc3c2)OC1(C)C.CCOC(C)=O.CO.Cc1cc(=O)n(C[C@@H]2CCN(C(=O)C3CC3)C2)c(-c2ccc(Br)cc2)n1.ClCCl.Cl[Pd]Cl.O=C([O-])[O-].[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cc(=O)n(C[C@@H]2CCN(C(=O)C3CC3)C2)c(-c2ccc(-c3ccc4occc4c3)cc2)n1",
        "output": "933"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCC.CCOC(C)=O.COc1cccc(-c2ccc(-c3cccc(OC)c3)s2)c1>>Oc1cccc(-c2ccc(-c3cccc(O)c3)s2)c1",
        "output": "20"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCCCCCCCCCCCCCNC(=O)OCC(CN)OC.CCN(CC)CC.ClCCl.O=S(=O)(Cl)CCCCCl>>CCCCCCCCCCCCCCCCCCNC(=O)OCC(CNS(=O)(=O)CCCCCl)OC",
        "output": "493"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC#Cc1cc(Cl)c(N)c2c1OCO2.CN(C)C=O.COc1cc2c(Cl)ncnc2cc1OCCCN1CCOCC1.C[Si](C)(C)[N-][Si](C)(C)C.[Na+]>>CCOCC#Cc1cc(Cl)c(Nc2ncnc3cc(OCCCN4CCOCC4)c(OC)cc23)c2c1OCO2",
        "output": "352"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(O)C(F)(F)F.O=C(O)c1cccc([N+](=O)[O-])c1.O=C1CCC(=O)N1Br.O=S(=O)(O)O>>O=C(O)c1cc(Br)cc([N+](=O)[O-])c1",
        "output": "4"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)C1(c2cc(F)cc(OCc3ccc4c(Cl)cc(Cl)nc4c3)c2)CCOCC1.NN>>COC(=O)C1(c2cc(F)cc(OCc3ccc4c(Cl)cc(NN)nc4c3)c2)CCOCC1",
        "output": "417"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)NCCN.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[K+].[K+]>>CC(C)NCCNc1ccc([N+](=O)[O-])cc1",
        "output": "572"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COC(=O)CCCCc1ncc(-c2cc(Cl)ccc2O)o1.Cl.O.[Li+].[OH-]>>O=C(O)CCCCc1ncc(-c2cc(Cl)ccc2O)o1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(N)c1ccc(C(F)(F)F)cc1[N+](=O)[O-].O=Cc1c(O)cc(O)cc1O>>CN(N=Cc1c(O)cc(O)cc1O)c1ccc(C(F)(F)F)cc1[N+](=O)[O-]",
        "output": "167"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(Cl)c(N)c1.O=c1[nH]c2nccc(Cl)c2c2ccccc12>>COc1ccc(Cl)c(Nc2ccnc3[nH]c(=O)c4ccccc4c23)c1",
        "output": "922"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1ccc2ccccc2c1.O=C(NCC1CNCCO1)Nc1ccc(Cl)cc1>>O=C(NCC1CN(Cc2ccc3ccccc3c2)CCO1)Nc1ccc(Cl)cc1",
        "output": "248"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN1CCNCC1.O.O=C(Cl)Oc1ccc(Cl)cc1.[Br-].[K+]>>CN1CCN(C(=O)Oc2ccc(Cl)cc2)CC1",
        "output": "219"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.[C].[H][H].[Pd].c1ccc(COc2ccc(CCCCn3ccnn3)cc2)cc1>>Oc1ccc(CCCCn2ccnn2)cc1",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CNCCCOc1cc(Br)c(N)c(Br)c1.COc1cc2c(cc1OC)CC(=O)N(CCCCl)CC2>>COc1cc2c(cc1OC)CC(=O)N(CCCN(C)CCCOc1cc(Br)c(N)c(Br)c1)CC2",
        "output": "138"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCCCCCN=C=O.Oc1ccc2c(c1)CCCN2Cc1ccccc1.c1ccncc1>>CCCCCCCNC(=O)Oc1ccc2c(c1)CCCN2Cc1ccccc1",
        "output": "104"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.Cl.ClCCl.NCCc1ccc(Cl)cc1.O.O=C(O)C1CCN(C(=O)c2cc3ccccc3n2Cc2ccc(Cl)cc2)CC1.On1nnc2ccccc21>>O=C(NCCc1ccc(Cl)cc1)C1CCN(C(=O)c2cc3ccccc3n2Cc2ccc(Cl)cc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CCc1cc(-c2ccc(S(=O)(=O)Cl)s2)c(C)[nH]c1=O.ClCCl.c1ccc(N2CCNCC2)cc1>>CCc1cc(-c2ccc(S(=O)(=O)N3CCN(c4ccccc4)CC3)s2)c(C)[nH]c1=O",
        "output": "798"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CS(C)=O.O.O=S(=O)(Nc1ccc2c(Cl)nccc2c1)c1ccc(Cl)cc1.[H-].[Na+]>>CCOc1nccc2cc(NS(=O)(=O)c3ccc(Cl)cc3)ccc12",
        "output": "433"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)CCNC(=O)c1cc2nccc(Cl)c2s1.Cc1cc2cc(N)ccc2[nH]1>>Cc1cc2cc(Nc3ccnc4cc(C(=O)NCCN(C)C)sc34)ccc2[nH]1",
        "output": "927"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.COC(=O)Cc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)Cc1ccc(OC(C)=O)cc1",
        "output": "46"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.Cc1cc(Cl)ccn1.Cl.O.O=C1CCNCC1>>Cc1cc(N2CCC(=O)CC2)ccn1",
        "output": "398"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)n1cc(C(=O)c2cc(N)ncn2)c2cncnc21.C[Si](C)(C)[N-][Si](C)(C)C.O=C(Cl)Cc1ccc(Cl)cc1.[Na+]>>CC(C)n1cc(C(=O)c2cc(NC(=O)Cc3ccc(Cl)cc3)ncn2)c2cncnc21",
        "output": "332"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc2c(O)nc(N(C)Cc3ccccc3)cc2c1.O=P(Cl)(Cl)Cl>>COc1ccc2c(Cl)nc(N(C)Cc3ccccc3)cc2c1",
        "output": "41"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCCCOc1ccc(Br)cc1.CCCCCCOc1ccc(Br)cc1.COB(OC)OC.II.O=S(=O)(O)O.[Mg]>>CCCCCCOc1ccc(B(O)O)cc1",
        "output": "789"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1ccc(C(F)(F)F)cc1.Nc1nc(Cl)cc(-c2cc(Cl)cc(Cl)c2)n1>>Nc1nc(Nc2ccc(C(F)(F)F)cc2)cc(-c2cc(Cl)cc(Cl)c2)n1",
        "output": "352"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.CCN(CC)CC.Clc1ccc(C(c2ccc(Cl)cc2)c2ccc3ncnc(Cl)c3c2)cc1.O=S(=O)(NC1CCNCC1)C(F)(F)F>>O=S(=O)(NC1CCN(c2ncnc3ccc(C(c4ccc(Cl)cc4)c4ccc(Cl)cc4)cc23)CC1)C(F)(F)F",
        "output": "296"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCC=O.CCN(CC)CC.Cl.Cn1cc(-c2cc3nccn3c(-c3cnn(C4(CC#N)CNC4)c3)n2)cn1.[Na+]>>CCCN1CC(CC#N)(n2cc(-c3nc(-c4cnn(C)c4)cc4nccn34)cn2)C1",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC[C@H](C)Oc1cc(OCc2ccccc2)cc(C(=O)O)c1.Cc1cc(N)nn1C.F[P-](F)(F)(F)(F)F>>COC[C@H](C)Oc1cc(OCc2ccccc2)cc(C(=O)Nc2cc(C)n(C)n2)c1",
        "output": "917"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCN(CC)CC.O=C(c1csc(-c2ccccc2)n1)N1CCOC2(CCNCC2)C1.OCCCCCCCCCBr>>O=C(c1csc(-c2ccccc2)n1)N1CCOC2(CCN(CCCCCCCCCO)CC2)C1",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.CCOC(C)=O.NCCO.O.O=C(O)Cc1ccc(-c2ccc(OCc3ccccc3)c(N3CC(=O)NS3(=O)=O)c2)cc1.On1nnc2ccccc21>>O=C(Cc1ccc(-c2ccc(OCc3ccccc3)c(N3CC(=O)NS3(=O)=O)c2)cc1)NCCO",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NC12CC3CC(CC(C3)C1)C2.O=Cc1ccc([N+](=O)[O-])cc1>>O=[N+]([O-])c1ccc(CNC23CC4CC(CC(C4)C2)C3)cc1",
        "output": "468"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.CCCCCC.CCCCCC.Cc1ccc(S(=O)(=O)OCC(F)(F)C(F)F)cc1.O=Cc1ccc(O)cc1.[H-].[H][H].[Na+].c1ccccc1>>O=Cc1ccc(OCC(F)(F)C(F)F)cc1",
        "output": "438"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCN(CC)CC.CCN=C=NCCCN(C)C.COc1ccc(CN2Cc3sc(N)c(C(=O)OC(C)(C)C)c3CC2CN)cc1.Cl.O=C(O)c1ccccc1OCc1ccccc1>>COc1ccc(CN2Cc3sc(N)c(C(=O)OC(C)(C)C)c3CC2CNC(=O)c2ccccc2OCc2ccccc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CO.COc1ccc(-c2c(C)cnnc2C)c(OC)c1.C[Si](C)(C)I>>COc1cc(O)ccc1-c1c(C)cnnc1C",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.O=S(=O)(O)O.O=[N+]([O-])O>>Cc1ccc(S(=O)(=O)Cl)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc2cc(N)ccc2[nH]1.Cn1c(-c2cc3nccc(Cl)c3s2)cnc1C(C)(O)CO>>Cc1cc2cc(Nc3ccnc4cc(-c5cnc(C(C)(O)CO)n5C)sc34)ccc2[nH]1",
        "output": "927"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "OCc1ccc(OCC(F)(F)C(F)F)nc1.[Mn+4].[O-2].[O-2]>>O=Cc1ccc(OCC(F)(F)C(F)F)nc1",
        "output": "520"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CCC(c2c[nH]c3ccc(N)cc23)CC1.O=C(O)c1ccc(-c2ccccc2)cc1>>CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(-c5ccccc5)cc4)cc23)CC1",
        "output": "50"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Clc1nccc2cc3c(cc12)OCO3.NCCCCCO.O=C([O-])[O-].[Na+].[Na+]>>OCCCCCNc1nccc2cc3c(cc12)OCO3",
        "output": "70"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC1CCN(C(=O)c2ccc(-c3ccn4ncc(-c5ccc(C#N)cc5)c4n3)cc2)CC1.Cl.ClCCl.O=C([O-])O.[Na+]>>N#Cc1ccc(-c2cnn3ccc(-c4ccc(C(=O)N5CCC(N)CC5)cc4)nc23)cc1",
        "output": "538"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O=C(NCC(F)(F)F)c1cc(F)cc([N+](=O)[O-])c1O>>Nc1cc(F)cc(C(=O)NCC(F)(F)F)c1O",
        "output": "489"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.O=C(O)c1ccc(O)c([N+](=O)[O-])c1>>CCOC(=O)c1ccc(O)c([N+](=O)[O-])c1",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Nc1ccccc1S.O=[N+]([O-])c1ccc(Cl)c([N+](=O)[O-])c1.[Na+].[OH-]>>Nc1ccccc1Sc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]",
        "output": "233"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOP(=O)(CCCCc1ccccc1)CC(=O)N1CC2(C[C@H]1C(=O)OC(c1ccccc1)c1ccccc1)SCCS2.C[Si](C)(C)Br.ClCCl>>O=C(OC(c1ccccc1)c1ccccc1)[C@@H]1CC2(CN1C(=O)CP(=O)(O)CCCCc1ccccc1)SCCS2",
        "output": "618"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.O.O=C(O)c1ccc(Cl)c(O)c1>>CC(=O)Oc1cc(C(=O)O)ccc1Cl",
        "output": "46"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc2c(c1)OC[C@@H](c1cccc(C(F)(F)F)c1)[C@H]2c1ccc(OCCN2CCCC2)cc1.Cl.c1ccncc1>>Oc1ccc2c(c1)OC[C@@H](c1cccc(C(F)(F)F)c1)[C@H]2c1ccc(OCCN2CCCC2)cc1",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O.O=S(=O)(O)Cl.[Cl-].[Na+].c1ccc(N2CCOCC2)cc1>>O=S(=O)(Cl)c1ccc(N2CCOCC2)cc1",
        "output": "182"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCI.CN1CCCC1=O.Cc1ccc(C(=O)O)c(=O)n1-c1cccc(C(F)(F)F)c1.O=C([O-])[O-].[Na+].[Na+]>>CCOC(=O)c1ccc(C)n(-c2cccc(C(F)(F)F)c2)c1=O",
        "output": "196"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.C[C@@H](CO)NC(=O)OCc1ccccc1.ClCCl>>C[C@@H](COS(C)(=O)=O)NC(=O)OCc1ccccc1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cl.NCCc1ccc(C(=O)CCC(=O)O)cc1>>CCOC(=O)CCC(=O)c1ccc(CCN)cc1",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc([C@H](C)N)cc1.O=C(O)Cn1nnc2ccc(F)cc2c1=O>>Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1",
        "output": "599"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.CCN(CC)CC.Cc1c[nH]c2ncnc(Cl)c12.Cl.O=C(Nc1cccc(Oc2ccc(F)cc2)c1)C1CCNCC1>>Cc1c[nH]c2ncnc(N3CCC(C(=O)Nc4cccc(Oc5ccc(F)cc5)c4)CC3)c12",
        "output": "540"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.COc1cc(Cl)nnc1NS(=O)(=O)Cc1ccc(C#N)cc1.ClCCl>>N#Cc1ccc(CS(=O)(=O)Nc2nnc(Cl)cc2O)cc1",
        "output": "424"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)CC(C)C.CNC.COc1cc(C=CC(=O)N[C@@H]2CC[C@@H](C)CC2)ccc1OCCCl>>COc1cc(C=CC(=O)N[C@@H]2CC[C@@H](C)CC2)ccc1OCCN(C)C",
        "output": "138"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1ccc(Nc2cccc(CO)c2)c([N+](=O)[O-])c1.CO.[Pd]>>CCOC(=O)c1ccc(Nc2cccc(CO)c2)c(N)c1",
        "output": "481"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.Cl.Cn1nc(C(C)(C)C)cc1NC(=O)Nc1cccc(C#Cc2cnc(Cl)nc2)c1.NCCCN1CCCCC1>>Cn1nc(C(C)(C)C)cc1NC(=O)Nc1cccc(C#Cc2cnc(NCCCN3CCCCC3)nc2)c1",
        "output": "544"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)C=O.O=C(O)c1c[nH]nc1C1CC1.[Cl-].[H-].[NH4+].[Na+]>>CC(C)(C)OC(=O)n1cc(C(=O)O)c(C2CC2)n1",
        "output": "841"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1ccccc1.O=C1C=CC(=O)O1.c1ccccc1>>O=C1C=CC(=O)N1c1ccccc1",
        "output": "410"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cl.O=C1CCN(C(=O)Nc2ccc(Cl)cc2)CC1.[BH4-].[Na+]>>O=C(Nc1ccc(Cl)cc1)N1CCC(O)CC1",
        "output": "91"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ncsc1-c1ccc(CN)c(O)c1.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+]>>Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)OC(C)(C)C)c(O)c1",
        "output": "797"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(I)cc1F.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>Fc1cc(I)ccc1CBr",
        "output": "29"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCNC(C)C.CCN(CC)CC.C[Si](C)(C)c1cccc(Cl)c1C(=O)Cl.Cc1ccccc1.Cl>>CCCN(C(=O)c1c(Cl)cccc1[Si](C)(C)C)C(C)C",
        "output": "201"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1.CO.Cl>>CC1(C)OB(C2=CCNCC2)OC1(C)C",
        "output": "800"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)Cn1c(C)c(Cc2ccc(=O)[nH]c2)c2ccccc21.COC(=O)Cn1c(C)c(Cc2ccc(=O)n(Cc3ccc(F)cc3F)c2)c2ccccc21.Fc1cc(F)cc(CBr)c1.O=C([O-])[O-].[K+].[K+]>>COC(=O)Cn1c(C)c(Cc2ccc(=O)n(Cc3cc(F)cc(F)c3)c2)c2ccccc21",
        "output": "528"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)C(Cc1ccc(-c2ccccc2Oc2ccccc2)cc1)NC(=O)c1cc(Cl)ccc1N1CC(C)CC(C)C1.[Li+].[OH-]>>CC1CC(C)CN(c2ccc(Cl)cc2C(=O)NC(Cc2ccc(-c3ccccc3Oc3ccccc3)cc2)C(=O)O)C1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "N#Cc1ccc(CBr)c(F)c1.Oc1cc(Cl)ccc1-c1nc2ccccc2n1CC1CCCCC1>>N#Cc1ccc(COc2cc(Cl)ccc2-c2nc3ccccc3n2CC2CCCCC2)c(F)c1",
        "output": "127"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1ccccc1C(=O)O.O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1c2c2cc(O)ccc2n1CCCBr>>O=C(O)c1ccccc1NCCCn1c2ccc(O)cc2c2c3c(c(-c4ccccc4Cl)cc21)C(=O)NC3=O",
        "output": "273"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)NS(=O)(=O)c1cc(C(=O)O)c(Cl)cc1F.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1nc2ccccc2n1C1C[C@H]2CC[C@@H](C1)N2CCC1(c2cccc(F)c2)CCNCC1.F[P-](F)(F)(F)(F)F>>Cc1nc2ccccc2n1C1C[C@H]2CC[C@@H](C1)N2CCC1(c2cccc(F)c2)CCN(C(=O)c2cc(S(=O)(=O)NC(C)C)c(F)cc2Cl)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc2[nH]cc(C(N)=O)c2c1.O=P(Cl)(Cl)Cl>>COc1ccc2[nH]cc(C#N)c2c1",
        "output": "624"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(C)=O.Fc1ccc(CCl)cc1.O=C([O-])[O-].O=[N+]([O-])c1ccc(O)cc1F.[K+].[K+]>>O=[N+]([O-])c1ccc(OCc2ccc(F)cc2)cc1F",
        "output": "49"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cccc(C)n1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.OC[C@@H]1CCCO1>>O=S(=O)(OC[C@@H]1CCCO1)C(F)(F)F",
        "output": "582"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(C)=O.COc1ncccc1CN1CCC(CCc2ccccc2C)CC1.Cl>>Cc1ccccc1CCC1CCN(Cc2ccc[nH]c2=O)CC1",
        "output": "758"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc2c(Oc3ccc4[nH]c(C)cc4c3)ncnc2cc1O.OCCOCCN1CCOCC1>>COc1cc2c(Oc3ccc4[nH]c(C)cc4c3)ncnc2cc1OCCOCCN1CCOCC1",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCN(CC)CC.CCNCC.O.O=C(CCCCl)c1ccc(Br)cc1>>CCN(CC)CCCC(=O)c1ccc(Br)cc1",
        "output": "138"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCCCCOc1ccc2c(-c3ccc(Br)cc3)nsc2c1.C1COCCN1>>Brc1ccc(-c2nsc3cc(OCCCCN4CCOCC4)ccc23)cc1",
        "output": "73"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cc1ccc(S(=O)(=O)O)cc1.ClC(Cl)Cl.O.O=C(O)CCCCCCCCCCBr>>CCOC(=O)CCCCCCCCCCBr",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCN(C(C)C)C(C)C.Cl.NC1Cc2ccccc2C1.O=C=NCCCl>>O=C(NCCCl)NC1Cc2ccccc2C1",
        "output": "244"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CN2CCC1CN2.C1COCCN1.CS(C)=O.O=C(O)c1cn(C2CC2)c2c(F)c(F)c(F)cc2c1=O>>O=C(O)c1cn(C2CC2)c2c(F)c(N3CCOCC3)c(F)cc2c1=O",
        "output": "676"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN.CO.COC(=O)COc1ccc(S(=O)(=O)n2cc(CN(C)C(=O)OC(C)(C)C)cc2-c2ccccc2F)cc1>>CNC(=O)COc1ccc(S(=O)(=O)n2cc(CN(C)C(=O)OC(C)(C)C)cc2-c2ccccc2F)cc1",
        "output": "392"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)[O-].CC(C)(C)[Si](C)(C)OCCO.CC1(C)C[C@H](Nc2nc(Nc3ccc(OCCO)c(Cl)c3)ncc2F)C[C@@H]2CCCN21.Cc1cc([N+](=O)[O-])ccc1F.[K+]>>Cc1cc([N+](=O)[O-])ccc1OCCO[Si](C)(C)C(C)(C)C",
        "output": "485"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=C(/C=C/P(=O)(OCC)OCC)CCO[Si](C)(C)C(C)(C)C.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>C=C(/C=C/P(=O)(OCC)OCC)CCO",
        "output": "708"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCO.COC(=O)c1ccc(SC)c([N+](=O)[O-])c1.O.[Na+].[OH-]>>CSc1ccc(C(=O)O)cc1[N+](=O)[O-]",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NC1CCC(Nc2nccn3c(-c4ccnc(NCc5ccccc5Cl)n4)cnc23)CC1.CCO.Cl>>NC1CCC(Nc2nccn3c(-c4ccnc(NCc5ccccc5Cl)n4)cnc23)CC1",
        "output": "538"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(N2CCOCC2)c2sc(N)nc12.O=C(Cl)Cc1ccccc1>>COc1ccc(N2CCOCC2)c2sc(NC(=O)Cc3ccccc3)nc12",
        "output": "553"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC(CCN)CC1.O=C(O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(Cl)cc2Cl)cc1>>CC(C)(C)OC(=O)N1CCC(CCNC(=O)c2ccc(S(=O)(=O)Nc3ccccc3Oc3ccc(Cl)cc3Cl)cc2)CC1",
        "output": "835"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)CC1(O)CCN(Cc2ccccc2)CC1.CO.N>>NC(=O)CC1(O)CCN(Cc2ccccc2)CC1",
        "output": "163"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.NC1CC1.O=C(O)c1c[nH]c(=O)c(Br)c1>>O=C(NC1CC1)c1c[nH]c(=O)c(Br)c1",
        "output": "674"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)N=C=O.Oc1ccc(-c2nn(C3CCCC3)c3c(F)cccc23)cc1>>CC(C)(C)NC(=O)Oc1ccc(-c2nn(C3CCCC3)c3c(F)cccc23)cc1",
        "output": "104"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1cc(Br)cc(C(C)C)n1.CCc1cc(Br)cc[n+]1[O-].C[Si](C)(C)C#N>>CCc1cc(Br)cc(C#N)n1",
        "output": "720"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(O)C(F)(F)F.CN(C)C=O.Clc1cccc(CBr)c1.O.[H-].[Na+]>>CC(C)(OCc1cccc(Cl)c1)C(F)(F)F",
        "output": "464"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.CCOC(=O)CBr.CCOC(=O)c1c(C(F)(F)F)nc(C(F)(F)F)c(C)c1O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)COc1c(C)c(C(F)(F)F)nc(C(F)(F)F)c1C(=O)OCC",
        "output": "123"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCCc1ccccc1.COc1ccc(N2CCNCC2)cc1.CS(=O)(=O)OCCCC1CCCC1.Cl.Cl.Fc1cc(N2CCNCC2)ccc1OCc1ccccc1>>Fc1cc(N2CCN(CCCC3CCCC3)CC2)ccc1OCc1ccccc1",
        "output": "496"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "OB(O)c1ccc(OC(F)(F)F)cc1.OC(Cc1cccc(F)c1)(c1cncnc1)c1ccc(Br)cn1>>OC(Cc1cccc(F)c1)(c1cncnc1)c1ccc(-c2ccc(OC(F)(F)F)cc2)cn1",
        "output": "833"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Clc1ccnc2cc(Br)sc12.O=[N+]([O-])c1ccc(O)cc1.O=[N+]([O-])c1ccc(Oc2ccnc3cc(Br)sc23)c(F)c1>>O=[N+]([O-])c1ccc(Oc2ccnc3cc(Br)sc23)cc1",
        "output": "936"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CO.Cl.O=C(NCc1ccc(F)cc1)c1cnc(C(=O)O)c(OCc2ccccc2)c1O.On1nnc2ccccc21>>COC(=O)c1ncc(C(=O)NCc2ccc(F)cc2)c(O)c1OCc1ccccc1",
        "output": "195"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCP(=O)=O.CCN(CC)CC.CCN(CC)c1cccc(N)c1.CN(C)C=O.Cc1ccc(C(=O)O)cc1Nc1nccc(-c2cccnc2)n1.O=C([O-])O.[Na+]>>CCN(CC)c1cccc(NC(=O)c2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)c1",
        "output": "50"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC1=C(N2CCNCC2)C(=O)c2ccccc2C1=O.O=C=Nc1ccc(Cl)cc1>>CC1=C(N2CCN(C(=O)Nc3ccc(Cl)cc3)CC2)C(=O)c2ccccc2C1=O",
        "output": "323"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.CC(C)=O.O=C([O-])[O-].Oc1cccnc1Cl.[K+].[K+]>>Clc1ncccc1OCc1ccccc1",
        "output": "623"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(C=O)cc1O.CS(=O)(=O)Cl.ClCCl>>COc1ccc(C=O)cc1OS(C)(=O)=O",
        "output": "149"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)CC(=O)CCl.CCOC(=O)Cc1csc2cc(OCc3sc(-c4ccc(C(F)(F)F)cc4)nc3C)cc(C)c12.COc1cc(C)cc(S)c1>>Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1cc(C)c2c(CC(=O)O)csc2c1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cnn(-c2ccncc2N2CCC(C(=O)O)CC2)c1.Cl.F[P-](F)(F)(F)(F)F.N[C@H]1CCOC1.O>>Cc1cnn(-c2ccncc2N2CCC(C(=O)N[C@H]3CCOC3)CC2)c1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)[C@@H]1[C@H](C#CC(=O)OCC(Cl)(Cl)Cl)C1(C)C.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1>>CC1(C)[C@H](C(=O)O)[C@@H]1C#CC(=O)OCC(Cl)(Cl)Cl",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=CCSc1ccc(OCCN)cc1.CCOC(=O)Cl>>CCOC(=O)NCCOc1ccc(SCC=C(C)C)cc1",
        "output": "94"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(c2cccc(N)c2)CC1.ClCCl.O=C([O-])O.[Na+]>>CC(=O)Nc1cccc(C2CCN(C(=O)OC(C)(C)C)CC2)c1",
        "output": "6"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNCC1.CCO.Cc1c(C=O)[nH]c2c1C(=O)N(C[C@H](O)CN1CCOCC1)CC2.O=C1Cc2c(cccc2-c2cccc(F)c2F)N1>>Cc1c(/C=C2\\C(=O)Nc3cccc(-c4cccc(F)c4F)c32)[nH]c2c1C(=O)N(C[C@H](O)CN1CCOCC1)CC2",
        "output": "911"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)[C@@H]1Cc2cccc(NC(C)=O)c2N1C(=O)CNC(=O)[C@@H](NC(=O)Cc1ccccc1)[C@@H](C)CC.O.[Li]O>>CC[C@H](C)[C@H](NC(=O)Cc1ccccc1)C(=O)NCC(=O)N1c2c(cccc2NC(C)=O)C[C@H]1C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)[C@H]1C[C@@H]1c1ccc(Br)cc1.Cl[Pd]Cl.[Fe+2].[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COC(=O)[C@H]1C[C@@H]1c1ccc(B2OC(C)(C)C(C)(C)O2)cc1",
        "output": "942"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COCCOc1cc2ncc(C#N)c(Cl)c2cc1OCc1ccccc1.CSc1ccccc1.O=C(O)C(F)(F)F>>COCCOc1cc2ncc(C#N)c(Cl)c2cc1O",
        "output": "23"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)Cn1c2c(ccc1=O)C(=O)CCC2.[Na+].[OH-]>>O=C(O)Cn1c2c(ccc1=O)C(=O)CCC2",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.O=C(O)CN1CCCC(c2ccccc2)(c2ccccc2)C1=O.c1ccc(C2CNCCO2)cc1>>O=C(CN1CCCC(c2ccccc2)(c2ccccc2)C1=O)N1CCOC(c2ccccc2)C1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCCCCCCCCCNCCCCCCCCCCCCCCCCCC.ClC(Cl)Cl.N#Cc1ccc(CBr)cc1>>CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)Cc1ccc(C#N)cc1",
        "output": "248"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N1CCC(C(=O)O)CC1.CC(Cl)Cl.Cl.Fc1cccc(F)c1.O=S(Cl)Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)N1CCC(C(=O)c2ccc(F)cc2F)CC1",
        "output": "435"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)c1cccc(CBr)c1.CCN(CC)CC.CO.NC1CC1>>CC(=O)c1cccc(CNC2CC2)c1",
        "output": "446"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClCCl.NCCCNc1ccc(-c2c[nH]c3cc(F)ccc23)cn1>>CC(=O)NCCCNc1ccc(-c2c[nH]c3cc(F)ccc23)cn1",
        "output": "45"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)c1ccc2nc(-c3ccccc3)c(Cl)nc2c1.CS(C)=O.NC1CC1>>COC(=O)c1ccc2nc(-c3ccccc3)c(NC3CC3)nc2c1",
        "output": "148"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "B.C1CCOC1.CO.O=C(O)c1cccc2c(Br)cccc12>>OCc1cccc2c(Br)cccc12",
        "output": "72"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1n[nH]c2ccccc12.COCCBr>>CCOC(=O)c1nn(CCOC)c2ccccc12",
        "output": "577"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(NCCN(C)C)c1nc2n(c(=O)c1Cc1ccccc1)CCCC2.ClCCl.O=C(Cl)c1ccc(Cl)cc1.O=C([O-])[O-].[K+].[K+]>>CCC(c1nc2n(c(=O)c1Cc1ccccc1)CCCC2)N(CCN(C)C)C(=O)c1ccc(Cl)cc1",
        "output": "201"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.O.O=C(C1Cc2ccc(OCc3ccccc3)cc21)N(CCO)Cc1ccccc1.O=C([O-])O.[Na+]>>O=CCN(Cc1ccccc1)C(=O)C1Cc2ccc(OCc3ccccc3)cc21",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNC.CO.Clc1cc(N2CCNCC2)c(Cl)nn1>>CN(C)c1nnc(Cl)cc1N1CCNCC1",
        "output": "406"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)c1cc2ccc(CC(=O)O)cc2s1.CN(C)C=O.Nc1ccccc1.On1nnc2ccccc21>>CCOC(=O)c1cc2ccc(CC(=O)Nc3ccccc3)cc2s1",
        "output": "365"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(C)(C)N.CCN(C(C)C)C(C)C.CCOc1ccc2c(c1)n(C1CCCCC1)c(=O)n2S(=O)(=O)c1ccc(C(=O)O)cc1OC.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.ClCCl.F[P-](F)(F)(F)(F)F>>CCOc1ccc2c(c1)n(C1CCCCC1)c(=O)n2S(=O)(=O)c1ccc(C(=O)NC(C)(C)CC)cc1OC",
        "output": "835"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCN(c2ccc(N)cc2)CC1.CCCCCC.CCOC(=O)c1cc2cnc(Cl)nc2nc1N.CCOC(C)=O>>CCOC(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cc3)nc2nc1N",
        "output": "592"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=C(O)c1ccc([N+](=O)[O-])cn1.O=C([O-])[O-].O=S(=O)(O)O.[Na+].[Na+]>>COC(=O)c1ccc([N+](=O)[O-])cn1",
        "output": "331"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#Cc1nc(NC(=O)C(C)N(C)C(=O)OC(C)(C)C)ccc1-c1c(C)nc2ccccn12.CCN(C(C)C)C(C)C.CN1CCCC1=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Cn1c(=O)ccc2cc(Br)ccc21.[Cu]I>>Cc1nc2ccccn2c1-c1ccc(NC(=O)C(C)N(C)C(=O)OC(C)(C)C)nc1C#Cc1ccc2c(ccc(=O)n2C)c1",
        "output": "659"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCNC1CCCCC1.CN(C)C=O.COc1ccc2nc(C(=O)C(C)(C)C)n(CC(=O)O)c2c1.ClCCCl.On1nnc2ccccc21>>CCN(C(=O)Cn1c(C(=O)C(C)(C)C)nc2ccc(OC)cc21)C1CCCCC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1c(-c2ccccc2)c(C(F)(F)F)nn1-c1ccc(CCNC(=O)Oc2ccccc2)cc1.NS(=O)(=O)c1cccc(O)c1>>Cc1c(-c2ccccc2)c(C(F)(F)F)nn1-c1ccc(CCNC(=O)NS(=O)(=O)c2cccc(O)c2)cc1",
        "output": "690"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.N#Cc1ccnc2[nH]ncc12.NO>>N=C(NO)c1ccnc2[nH]ncc12",
        "output": "854"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#CC1(O)CCN(C)C1=O.NC(=O)c1nc2c(s1)CCOc1cc(F)c(Br)cc1-2>>CN1CCC(O)(C#Cc2cc3c(cc2F)OCCc2sc(C(N)=O)nc2-3)C1=O",
        "output": "659"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.COc1cc(F)ccc1[N+](=O)[O-].OCC(CO)N1CCNCC1>>COc1cc(N2CCN(C(CO)CO)CC2)ccc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)SCC1(C(=O)NCC(O)C(=O)OCc2ccccc2)CCc2ccccc2C1.CSC.ClCCl.O=S(=O)(O)C(F)(F)F>>CC(=O)SCC1(C(=O)NCC(O)C(=O)O)CCc2ccccc2C1",
        "output": "186"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.O=C1c2cnc(N3CCN(Cc4ccccc4)CC3)nc2CN1C1CCCCC1.[Pd].c1cncnc1>>O=C1c2cnc(N3CCNCC3)nc2CN1C1CCCCC1",
        "output": "84"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)c1c[nH]nc1I.C[Si](C)(C)CCOCCl.ClCCl.O.[Cl-].[Na+]>>CCOC(=O)c1cn(COCC[Si](C)(C)C)nc1I",
        "output": "910"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.O=C([O-])O.OCCCc1ccc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)cn1.[Na+].c1ccncc1>>O=CCCc1ccc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)cn1",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(-c2nc3cc(Br)ccc3o2)cc1[N+](=O)[O-].OB(O)c1ccc(OC(F)(F)F)cc1>>COc1ccc(-c2nc3cc(-c4ccc(OC(F)(F)F)cc4)ccc3o2)cc1[N+](=O)[O-]",
        "output": "909"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOC(=O)Cc1cccc(O)c1.CN(C)C=O.O.c1c[nH]cn1>>CCOC(=O)Cc1cccc(O[Si](C)(C)C(C)(C)C)c1",
        "output": "746"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)CS(=O)(=O)N[C@@H]1CCCc2c(-c3noc(-c4ccc(OC(C)C)c(C#N)c4)n3)cccc21.Cl.O.[Na+].[OH-]>>CC(C)Oc1ccc(-c2nc(-c3cccc4c3CCC[C@H]4NS(=O)(=O)CC(=O)O)no2)cc1C#N",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].CCCc1nc(C)cc(=O)n1Cc1ccc(-c2ccccc2C#N)c(F)c1.[Na+]>>CCCc1nc(C)c(Br)c(=O)n1Cc1ccc(-c2ccccc2C#N)c(F)c1",
        "output": "381"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCN(CCCCl)CC1.COc1cc2c(Oc3ccc(-c4cncn(Cc5ccccc5)c4=O)cc3F)ccnc2cc1O.Cl>>COc1cc2c(Oc3ccc(-c4cncn(Cc5ccccc5)c4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CNC1.CC#N.CC(C)NC(C)C.CCn1ncc(C(=O)O)c1C(=O)Nc1ccn2cc(-c3ccccc3)nc2c1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O>>CCn1ncc(C(=O)N2CCC2)c1C(=O)Nc1ccn2cc(-c3ccccc3)nc2c1",
        "output": "733"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[Si](OC[C@H](O)CCN=[N+]=[N-])(c1ccccc1)c1ccccc1.[C].[Pb+2].[Pd].[Pd]>>CC(C)(C)[Si](OC[C@H](O)CCN)(c1ccccc1)c1ccccc1",
        "output": "89"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COc1cc(NC(=O)CBr)cc(OC)c1OC.Cc1onc2c1c(=O)n(C1CCCNC1)c1cccc(Cl)c21.I.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>COc1cc(NC(=O)CN2CCCC(n3c(=O)c4c(C)onc4c4c(Cl)cccc43)C2)cc(OC)c1OC",
        "output": "443"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.CO.O=C([O-])O.O=C1CCC(C(=O)O)(c2ccccc2)CC1.[Na+]>>COC(=O)C1(c2ccccc2)CCC(=O)CC1",
        "output": "195"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.CN1CCC(N(C)S(=O)(=O)c2ccc(Br)cc2)C1.O>>CN1CCC(N(C)S(=O)(=O)c2ccc(B(O)O)cc2)C1",
        "output": "832"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Cc1ccc(C(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c([N+](=O)[O-])c1.[Pd]>>Cc1ccc(C(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "O=C1CCCc2ccccc2N1.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O.O=[N+]([O-])O.O=[N+]([O-])O>>O=C1CCCc2cc([N+](=O)[O-])ccc2N1",
        "output": "21"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cc1nccn1CCCCN1C(=O)[C@@H](CC#N)O[C@H](c2cccc3ccccc23)c2cc(Cl)ccc21.O=C([O-])[O-].OO.[K+].[K+]>>Cc1nccn1CCCCN1C(=O)[C@@H](CC(N)=O)O[C@H](c2cccc3ccccc23)c2cc(Cl)ccc21",
        "output": "632"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCOC(=O)Cc1cccc2c(=O)cc(C3=CCCCC3)oc12.O>>O=C(O)Cc1cccc2c(=O)cc(C3=CCCCC3)oc12",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O=C([O-])O.O=Cc1cc(C(O)c2cccc(Cl)c2)co1.[Na+].c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OC(c1cccc(Cl)c1)c1coc(C=O)c1",
        "output": "193"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)N.CCCCCC(=O)Nc1ccc(OCC2CO2)c(C#N)c1.CCO>>CCCCCC(=O)Nc1ccc(OCC(O)CNC(C)C)c(C#N)c1",
        "output": "16"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Nc1ccc(CCCC2=NCCN2)cc1.O=C(Cl)OCc1ccccc1>>O=C(Nc1ccc(CCCC2=NCCN2)cc1)OCc1ccccc1",
        "output": "509"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)CC(NC(=O)N1CCCCCC1)C(=O)NC(Cc1ccc(O)cc1)C(=O)OC(C)(C)C.COc1ccc(CCl)cc1>>COc1ccc(COc2ccc(CC(NC(=O)C(CC(C)C)NC(=O)N3CCCCCC3)C(=O)OC(C)(C)C)cc2)cc1",
        "output": "49"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.COC(OC)c1cc(-c2cccc(C(C)(C)N)c2)n(C)n1.ClCCl.O=S(=O)(Cl)CC(F)(F)F>>COC(OC)c1cc(-c2cccc(C(C)(C)NS(=O)(=O)CC(F)(F)F)c2)n(C)n1",
        "output": "742"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1ccccc1NC(=O)Nc1ccc(CC(=O)NC(CC(C)C)C(=O)O)cc1.Cl.NCC(O)CC(=O)OCc1ccccc1.On1nnc2ccccc21>>Cc1ccccc1NC(=O)Nc1ccc(CC(=O)NC(CC(C)C)C(=O)NCC(O)CC(=O)OCc2ccccc2)cc1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)Oc1ccc(-c2nc(-c3cccc4c(C=O)cn(C)c34)no2)cc1Cl.CCO.CCOC(=O)C1CCNCC1.Cl.[Na+].[OH-]>>CCOC(=O)C1CCN(Cc2cn(C)c3c(-c4noc(-c5ccc(OC(C)C)c(Cl)c5)n4)cccc23)CC1",
        "output": "757"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCOC1(c2ccc(CCCCC)cc2)CC(F)=C(c2ccccc2)C=C1F.CCCCCCOc1ccc(B(O)O)c(F)c1.CCCCCc1ccc(-c2ccc(Br)cc2)c(F)c1>>CCCCCCOc1ccc(-c2ccc(-c3ccc(CCCCC)cc3F)cc2)c(F)c1",
        "output": "837"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=NOCc1nc2c(N)nc3ccccc3c2n1CCNC(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CC(C)=NOCc1nc2c(N)nc3ccccc3c2n1CCN",
        "output": "538"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Br.CC(=O)O.COc1ccc2c(c1)C(=O)CCC2>>O=C1CCCc2ccc(O)cc21",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.CC(C)c1noc(N2CCC(CCCO)CC2)n1.CS(=O)(=O)c1ccc(O)cc1F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)c1noc(N2CCC(CCCOc3ccc(S(C)(=O)=O)c(F)c3)CC2)n1",
        "output": "478"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "B.C1CCOC1.C1CCOC1.CC(C)(C)OC(=O)N1C[C@@H](F)C[C@H]1C(=O)O.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N1C[C@@H](F)C[C@H]1CO",
        "output": "218"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.C[C@@H]1CN[C@@H](C)CN1.Cc1c[nH]c2ncnc(Cl)c12>>Cc1c[nH]c2ncnc(N3C[C@@H](C)NC[C@@H]3C)c12",
        "output": "540"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.N[C@H]1CCCc2ccccc21.O=Cc1cccc(Oc2ccc(Cl)cc2)c1.[BH4-].[Na+]>>Clc1ccc(Oc2cccc(CN[C@H]3CCCc4ccccc43)c2)cc1",
        "output": "683"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.O=C(NCc1ccc(Br)cc1F)c1ccc(Br)cc1[N+](=O)[O-].[Fe].[Na+].[OH-]>>Nc1cc(Br)ccc1C(=O)NCc1ccc(Br)cc1F",
        "output": "486"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.ClCCCBr.OC1(c2ccccc2)CCNCC1.[Cl-].[Na+]>>OC1(c2ccccc2)CCN(CCCCl)CC1",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(O)CC(=O)O.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1>>CC(C)(O)CC(=O)N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCC1CC1.COc1cc(CC2c3cc(OC)c(OC)cc3CCN2CC(=O)NCc2ccccc2)ccc1O>>COc1cc2c(cc1OC)C(Cc1ccc(OCC3CC3)c(OC)c1)N(CC(=O)NCc1ccccc1)CC2",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.CCOC(=O)[C@@H]1CC(O[Si](C)(C)C(C)(C)C)C[C@H]1CO.ClCCl.Oc1ccc(Cl)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)[C@@H]1CC(O[Si](C)(C)C(C)(C)C)C[C@H]1COc1ccc(Cl)cc1",
        "output": "550"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.CCO.Cc1csc2c1-n1cccc1/C2=N/OCCN1C(=O)c2ccccc2C1=O.NN.O>>Cc1csc2c1-n1cccc1/C2=N/OCCN",
        "output": "242"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)CC1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCNCC1.CCN(CC)CC.CCOC(C)=O.O=C(O)C(F)(F)F.O=C1CCC(O)(c2ccc3c(c2)OCO3)CC1.[Na+]>>CC(C)CC1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN(C2CCC(O)(c3ccc4c(c3)OCO4)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CO.COc1nccc2nc(-c3ccc(C#N)cc3F)c(-c3ccccc3)cc12.ClCCl.N.O.[H][H].[Ni]>>COc1nccc2nc(-c3ccc(CN)cc3F)c(-c3ccccc3)cc12",
        "output": "175"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOc1ccccc1NC(=O)OC(C)(C)C.ClB1Oc2ccccc2O1.ClCCl>>CCOc1ccccc1N",
        "output": "782"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCNS(=O)(=O)c1ccc(Oc2ccc(CC)cc2OCc2ccccc2)c(F)c1.CCO>>CCNS(=O)(=O)c1ccc(Oc2ccc(CC)cc2O)c(F)c1",
        "output": "23"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCO.COC(=O)c1ncc2c(=O)n(Cc3ccc(OC)cc3OC)ccc2c1O.COCCN.O>>COCCNC(=O)c1ncc2c(=O)n(Cc3ccc(OC)cc3OC)ccc2c1O",
        "output": "487"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)COc1ccc(NC(=O)C(=O)N2CCN(c3ccccc3C(C)(C)C)CC2)cc1.Cl.[Li+].[OH-]>>CC(C)(C)c1ccccc1N1CCN(C(=O)C(=O)Nc2ccc(OCC(=O)O)cc2)CC1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCCC(=O)Cl.COc1cc(CN)ccc1O.Cl.O.O=C([O-])[O-].[K+].[K+].c1ccccc1>>CCCCCCCCC(=O)NCc1ccc(O)c(OC)c1",
        "output": "206"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.COc1cc2ncnc(Oc3ccc(N)c([N+](=O)[O-])c3)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.OC1CCCCCC1.[Na+]>>COc1cc2ncnc(Oc3ccc(NC(=O)OC4CCCCCC4)c([N+](=O)[O-])c3)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.Cc1cccc(SC(C)(C)C(=O)OC(C)(C)C)c1.O=C1CCC(=O)N1Br>>Cc1cc(SC(C)(C)C(=O)OC(C)(C)C)ccc1Br",
        "output": "4"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(O)c1cc2ccncc2[nH]1.[Mn+4].[O-2].[O-2]>>CC(=O)c1cc2ccncc2[nH]1",
        "output": "456"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccccc1.O=S(=O)(c1ccccc1)c1cc(CO)nn1-c1cccnc1F.[Mn+4].[O-2].[O-2]>>O=Cc1cc(S(=O)(=O)c2ccccc2)n(-c2cccnc2F)n1",
        "output": "573"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(CN)on1.Cl.O=C(O)c1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1>>COc1cc(CNC(=O)c2cnc(OCC(F)(F)F)c(-c3ccc(Cl)cc3)c2)on1",
        "output": "674"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](CN)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O.O=C(O)c1cc(Cl)ncc1Cl>>CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](CNC(=O)c2cc(Cl)ncc2Cl)CC1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)O.CN1C(=O)C(F)(F)CN([C@@H]2C[C@H]2c2ccccc2)c2nc(Cl)ncc21.COc1cc(C(=O)NC2CCN(C)CC2)ccc1N.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O.O=C([O-])[O-].[Na+].[Na+]>>COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N([C@@H]1C[C@H]1c1ccccc1)CC(F)(F)C(=O)N2C",
        "output": "941"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.COc1ccc(CCN)cc1OC.O=C(O)CN(c1ccccc1)c1ccccc1>>COc1ccc(CCNC(=O)CN(c2ccccc2)c2ccccc2)cc1OC",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)CCc1ccn(-c2ccc(-n3ccnc3)cc2)c1-c1ccc(C(N)=O)cc1C.CO.O>>Cc1cc(C(N)=O)ccc1-c1c(CCC(=O)O)ccn1-c1ccc(-n2ccnc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1cc([N+](=O)[O-])ccc1-c1cc(Cl)ccc1OC.COc1ccc(F)cc1-c1ccc([N+](=O)[O-])cc1C(=O)O>>COc1ccc(Cl)cc1-c1ccc([N+](=O)[O-])cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(C)O.COC(C)=O.Cc1ccc(N)c2[nH]cc(C#N)c12.Cl.N#Cc1cccc(S(=O)(=O)Cl)c1.O.c1ccncc1>>Cc1ccc(NS(=O)(=O)c2cccc(C#N)c2)c2[nH]cc(C#N)c12",
        "output": "554"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(O)CO.CN(C)C=O.Cc1nc(Cl)ccc1C#N.[H-].[Na+]>>Cc1nc(OCC(C)(C)O)ccc1C#N",
        "output": "433"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)Cc1cccc(N)c1.O=C(O)c1ccc(Br)cc1Cl>>CCOC(=O)Cc1cccc(NC(=O)c2ccc(Br)cc2Cl)c1",
        "output": "50"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COc1c(OCC(CN2CCCC2)OC(C)=O)c(Nc2ccccc2)c2nc(F)nc(Br)c2c1O.N>>COc1c(OCC(O)CN2CCCC2)c(Nc2ccccc2)c2nc(F)nc(Br)c2c1O",
        "output": "325"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.CCCCN(c1nc(Cl)nc(N(CCCC)C2CC(C)(C)N(OC3CCCCC3)C(C)(C)C2)n1)C1CC(C)(C)N(OC2CCCCC2)C(C)(C)C1.Cc1ccccc1.[Na+].[OH-]>>CCCCN(c1nc(N2CCOCC2)nc(N(CCCC)C2CC(C)(C)N(OC3CCCCC3)C(C)(C)C2)n1)C1CC(C)(C)N(OC2CCCCC2)C(C)(C)C1",
        "output": "214"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(-n2nccn2)c(CO)c1.ClC(Cl)Cl.O=S(Cl)Cl>>Cc1ccc(-n2nccn2)c(CCl)c1",
        "output": "81"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)[C@@H](NC(=O)c1ccc(-c2cnc3nnc(C4(c5ccc6ncsc6c5)CC4)n3n2)cc1)C(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CC(C)(C)[C@H](NC(=O)c1ccc(-c2cnc3nnc(C4(c5ccc6ncsc6c5)CC4)n3n2)cc1)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.CO.COc1cc(C(=O)N2CCC3(CC2)CC(O)c2ccccc2S3)ccc1OC(C)C.[H-].[Na+]>>COc1cc(C(=O)N2CCC3(CC2)CC(OC)c2ccccc2S3)ccc1OC(C)C",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)c1ccc2cc3ccccc3c(-c3ccc(Cl)cc3)c2c1.CN(C)C=O.O.O=C1CCC(=O)N1Br>>CC(C)(C)c1ccc2c(Br)c3ccccc3c(-c3ccc(Cl)cc3)c2c1",
        "output": "4"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Cc1c(OCCCN(Cc2cccc(C(F)(F)F)c2Cl)CC(c2ccccc2)c2ccccc2)cccc1[N+](=O)[O-].ClC(Cl)Cl.[Pd]>>Cc1c(N)cccc1OCCCN(Cc1cccc(C(F)(F)F)c1Cl)CC(c1ccccc1)c1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNS(=O)(=O)CCCCCN.ClCCl>>CNS(=O)(=O)CCCCCNC(=O)OC(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCO.CS(=O)(=O)NC(=O)C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)CCC(=O)O.O=S(Cl)Cl>>CCCCOC(=O)CCC(=O)N[C@@H](CC(=O)NS(C)(=O)=O)Cc1ccc(-c2cccc(Cl)c2)cc1",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1CCCC1=O.CO.Cl.ClCCl.Clc1nc(-c2ccc(N3CCOCC3)cc2)cc2ncccc12.Nc1ccc2cn[nH]c2c1>>c1cnc2cc(-c3ccc(N4CCOCC4)cc3)nc(Nc3ccc4cn[nH]c4c3)c2c1",
        "output": "352"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)CC=O.ClCCCl.O=C1Nc2ccccc2C2(CCNCC2)O1.[Na+]>>CC(C)CCN1CCC2(CC1)OC(=O)Nc1ccccc12",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CI.CN(C)C=O.O.OCCc1ccc(Br)cc1.[H-].[Na+]>>COCCc1ccc(Br)cc1",
        "output": "140"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.Fc1ccc2c(c1)OCCC2.O.O=C1CCC(=O)N1Br>>Fc1cc2c(cc1Br)CCCO2",
        "output": "4"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CCN=C=NCCCN(C)C.CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)O)cc4)cc3)nc21.CN1CCNCC1.On1nnc2ccccc21>>CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)N5CCN(C)CC5)cc4)cc3)nc21",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCc1noc(C)c1COc1ccc(C(=O)OC)cn1.NC1CCOCC1>>CCCCc1noc(C)c1COc1ccc(C(=O)NC2CCOCC2)cn1",
        "output": "862"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(O)c1ccc2c(n1)CCC(C(=O)O)C2.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCCC1=O.Cc1cc([C@@H](C)N)c(F)cc1NS(C)(=O)=O.Cl.F[P-](F)(F)(F)(F)F>>Cc1cc([C@@H](C)NC(=O)C2CCc3nc(C(C)(C)O)ccc3C2)c(F)cc1NS(C)(=O)=O",
        "output": "599"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCC1CO1.O=S(=O)(c1ccc(O)cc1)c1oc2ccccc2c1-c1ccccc1>>O=S(=O)(c1ccc(OCC2CO2)cc1)c1oc2ccccc2c1-c1ccccc1",
        "output": "18"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1ccc([Se]c2cc3c(cc2C)C(C)(C)CCC3(C)C)nc1.CO.O.[Na+].[OH-]>>Cc1cc2c(cc1[Se]c1ccc(C(=O)O)cn1)C(C)(C)CCC2(C)C",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.Cl.O=C(Nc1ccc(CNc2nc(Cl)nc3ccc(C(F)(F)F)cc23)cc1)C1CCN(Cc2ccc(F)cc2)CC1.c1cnc(N2CCNCC2)nc1>>O=C(Nc1ccc(CNc2nc(N3CCN(c4ncccn4)CC3)nc3ccc(C(F)(F)F)cc23)cc1)C1CCN(Cc2ccc(F)cc2)CC1",
        "output": "36"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.COc1ccc2c(=O)c(C(=O)O)cn(C)c2c1.O>>Cn1cc(C(=O)O)c(=O)c2ccc(O)cc21",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cc2cc(N)ccc2[nH]1.Cn1c(-c2cc3nccc(Cl)c3s2)cnc1C(=O)Nc1ccccn1>>Cc1cc2cc(Nc3ccnc4cc(-c5cnc(C(=O)Nc6ccccn6)n5C)sc34)ccc2[nH]1",
        "output": "927"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCOC(=O)COc1cc(OC)c2c(c1S(=O)(=O)Cl)OC1(CCCCC1)CC2=O.ClCCl.N>>CCOC(=O)COc1cc(OC)c2c(c1S(N)(=O)=O)OC1(CCCCC1)CC2=O",
        "output": "245"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClCCl.Oc1cccc(Br)c1>>CC(=O)Oc1cccc(Br)c1",
        "output": "111"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCC2=NCCCN2CC1.CC(C)Br.CCO.CCOC(C)=O.Cc1cccnc1C(=O)CCc1coc(-c2ccc(OC(F)F)c(O)c2)n1.O>>Cc1cccnc1C(=O)CCc1coc(-c2ccc(OC(F)F)c(OC(C)C)c2)n1",
        "output": "153"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C(O)CCc1ccccc1.O=P(Cl)(Cl)Cl.Oc1cc(O)cc(O)c1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(CCc1ccccc1)c1c(O)cc(O)cc1O",
        "output": "435"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccc(C(=O)O)cc1.Cl.Nc1nc(-c2ccco2)c(C(=O)C2CCOCC2)s1.O.O.On1nnc2ccccc21>>CN(C)c1ccc(C(=O)Nc2nc(-c3ccco3)c(C(=O)C3CCOCC3)s2)cc1",
        "output": "918"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.ClCCl.Nc1ccc(-c2ncn(-c3ccc(OC(F)(F)C(F)(F)F)cc3)n2)cc1.O=C(Cl)C(=O)Cl.O=C(O)c1cccc(-c2ccccc2)c1>>O=C(Nc1ccc(-c2ncn(-c3ccc(OC(F)(F)C(F)(F)F)cc3)n2)cc1)c1cccc(-c2ccccc2)c1",
        "output": "50"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCC1(CO)CCNCC1.COc1ccc(-c2nnc(C(=O)N3CC(Oc4ccc(C=O)cc4)C3)o2)cc1.ClCCl.[Na+]>>CCC1(CO)CCN(Cc2ccc(OC3CN(C(=O)c4nnc(-c5ccc(OC)cc5)o4)C3)cc2)CC1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2F)c(=O)n([C@@H]2CC[C@@H](OC3(C(C)(C)O)CC3)CC2)c2ncnn12.CCOC(C)=O.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2F)c(=O)n([C@@H]2CC[C@@H](OC3(C(C)(C)O)CC3)CC2)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCc1c([N+](=O)[O-])c(C(N)=O)nn1CCOC.[Pd]>>CCc1c(N)c(C(N)=O)nn1CCOC",
        "output": "628"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN1CCOCC1.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.ClCCl.NCc1ccc(F)cc1Cl.O=C(O)[C@@H]1CCC(=O)N1C1CCCC1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>O=C(NCc1ccc(F)cc1Cl)[C@@H]1CCC(=O)N1C1CCCC1",
        "output": "797"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "N#Cc1ccc(O)cc1.Nc1cc(Cl)ncn1.O=C([O-])[O-].[K+].[K+].c1ccncc1>>N#Cc1ccc(Oc2cc(N)ncn2)cc1",
        "output": "668"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2c[nH]c3ccccc23)CC1.CCN(CC)CC.CCNCCCNCC.CN(C)c1ccncc1.ClCCl.O=C(Cl)c1ccc(C(F)(F)F)cc1>>CC(C)(C)OC(=O)N1CCC(c2cn(C(=O)c3ccc(C(F)(F)F)cc3)c3ccccc23)CC1",
        "output": "232"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(=O)C1COCCC1N>>CCOC(=O)C1COCCC1NC(=O)OC(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)/C=C(\\C)c1cccc(C#N)c1.CO.O.O.[Li+].[OH-]>>C/C(=C\\C(=O)O)c1cccc(C#N)c1",
        "output": "122"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.COc1cc(F)c(-c2cc3nc(Cl)ccc3[nH]2)c(F)c1.Cc1cc(S(=O)(=O)N(C)C)ccc1B(O)O.Cl[Pd]Cl.O.O=C([O-])[O-].[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1cc(F)c(-c2cc3nc(-c4ccc(S(=O)(=O)N(C)C)cc4C)ccc3[nH]2)c(F)c1",
        "output": "865"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.O=S(Cl)Cl.O=[N+]([O-])c1cnc2ccccc2c1NCCCCCCO>>O=[N+]([O-])c1cnc2ccccc2c1NCCCCCCCl",
        "output": "96"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cc1cccc(-c2[nH]c(Cc3ccc(Cl)c([N+](=O)[O-])c3)nc2-c2ccc3ncccc3c2)n1.Cl[Sn]Cl>>Cc1cccc(-c2[nH]c(Cc3ccc(Cl)c(N)c3)nc2-c2ccc3ncccc3c2)n1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)C(CCNC(=O)OCc1ccccc1)C(O)CCc1ccc(-c2ccccc2)cc1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.ClCCl.O.O=C(O)c1ccccc1>>CC(C)(C)OC(=O)C(CCNC(=O)OCc1ccccc1)C(CCc1ccc(-c2ccccc2)cc1)OC(=O)c1ccccc1",
        "output": "33"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cl.Cl[Sn](Cl)(Cl)Cl.Nc1cccc(F)c1.O.O.O=N[O-].[Na+].[Na+].[OH-]>>NNc1cccc(F)c1",
        "output": "109"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(CN)c1nc(-c2ccc(Cl)cc2)cs1.O=C(O)c1cccc(-c2noc(C(F)(F)F)n2)n1>>CC(C)(CNC(=O)c1cccc(-c2noc(C(F)(F)F)n2)n1)c1nc(-c2ccc(Cl)cc2)cs1",
        "output": "137"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)c1ccc(CNc2ccc(C(=Cc3ccc(F)cc3)C(=O)NC3CC3)cc2)cc1.O.[Na+].[OH-]>>O=C(NC1CC1)C(=Cc1ccc(F)cc1)c1ccc(NCc2ccc(C(=O)O)cc2)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CNCCN1.O=S1CCN(c2nc(Cl)nc3c(N(CCO)Cc4ccccc4)ncnc23)CC1>>O=S1CCN(c2nc(N3CCNCC3)nc3c(N(CCO)Cc4ccccc4)ncnc23)CC1",
        "output": "36"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O.O=C(O)[C@H]1C[C@H](n2cc(-c3cn(S(=O)(=O)c4ccccc4)c4cc(F)ccc34)cn2)C1.O=S(=O)(c1ccccc1)n1cc(-c2cnn(C3CCC4(CC3)OCCO4)c2)c2ccc(F)cc21.[Na+].[OH-]>>Fc1ccc2c(-c3cnn(C4CCC5(CC4)OCCO5)c3)c[nH]c2c1",
        "output": "771"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccccc1CCC(=O)O.CNC.ClCCl.O.O=S(Cl)Cl>>CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccccc1CCC(=O)N(C)C",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CN1CCC(Oc2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1.[Pd]>>CN1CCC(Oc2ccc(N)cc2C(F)(F)F)CC1",
        "output": "202"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.Cc1cc(C(=O)O)[nH]c1C=C1C(=O)Nc2ccccc21.NCCCc1ccccc1>>Cc1cc(C(=O)NCCCc2ccccc2)[nH]c1C=C1C(=O)Nc2ccccc21",
        "output": "137"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)C[C@H](N[C@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)O.CCN(C(C)C)C(C)C.ClCCl.O[C@H]1CO[C@H]2[C@@H]1[NH2+]C[C@@H]2F.[Cl-]>>CC(C)C[C@H](N[C@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)N1C[C@H](F)[C@H]2OC[C@H](O)[C@H]21",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COCC(=O)Cl.ClCCl.NCc1nccs1.O>>COCC(=O)NCc1nccs1",
        "output": "45"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=Cc1ccc(-c2nccc(Cl)n2)cc1.OB(O)c1ccc(OC(F)(F)F)cc1.[Pd]>>O=Cc1ccc(-c2nccc(-c3ccc(OC(F)(F)F)cc3)n2)cc1",
        "output": "884"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC1(C)COC(=O)N1c1nc(-c2ccc(C#N)cc2)cs1.CCOC(C)=O.CS(C)=O.NO>>CC1(C)COC(=O)N1c1nc(-c2ccc(C(N)=NO)cc2)cs1",
        "output": "400"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCN(CC)CC.COCCCOc1cc(C[C@@H](C[C@H](NC(=O)OC(C)(C)C)[C@@H](O)CN)C(C)C)ccc1OC.O=C(Cl)N1CCCCC1>>COCCCOc1cc(C[C@@H](C[C@H](NC(=O)OC(C)(C)C)[C@@H](O)CNC(=O)N2CCCCC2)C(C)C)ccc1OC",
        "output": "454"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCCO.CN(C)C=O.N#Cc1ccc(CBr)cc1.O.[H-].[Na+]>>CCCCOCc1ccc(C#N)cc1",
        "output": "464"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.COc1cccc(Oc2c(NCCO)ncnc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1.Clc1ncccn1.[Cl-].[H-].[NH4+].[Na+]>>COc1cccc(Oc2c(NCCOc3ncccn3)ncnc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1",
        "output": "37"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.N#Cc1nc(-c2cccc(C(F)(F)F)c2)cc(N2CCCNCC2)n1.O=C(O)C(F)(F)F.[Na+]>>CN1CCCN(c2cc(-c3cccc(C(F)(F)F)c3)nc(C#N)n2)CC1",
        "output": "217"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O",
        "output": "626"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COc1ccc(S(=O)(=O)Cl)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1.O=Cc1c[nH]c2cc(Cl)ccc12.[H-].[Na+]>>COc1ccc(S(=O)(=O)n2cc(C=O)c3ccc(Cl)cc32)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1",
        "output": "648"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.COC(=O)C1CCNCC1.ClCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)C1CCN(Cc2ccccc2)CC1",
        "output": "156"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)Cc1ccc(-c2nc(COc3cc(COc4nn(-c5ccccc5)cc4/C=C/c4csc(CC)n4)on3)c(C)o2)cc1.Cl.O.[Na+].[OH-]>>CCc1nc(/C=C/c2cn(-c3ccccc3)nc2OCc2cc(OCc3nc(-c4ccc(CC(=O)O)cc4)oc3C)no2)cs1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.CCN=C=NCCCN(C)C.CS(C)=O.Cc1c(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(F)cc2)sc(C(=O)O)c1Cl.On1nnc2cccnc21>>Cc1c(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(F)cc2)sc(C(=O)N2CCOCC2)c1Cl",
        "output": "857"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)C(Cc1ccc(OC(c2ccccc2)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C)OCC.[Li+].[OH-]>>CCOC(Cc1ccc(OC(c2ccccc2)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.Cc1ccc(S(=O)(=O)N(Cc2ccc(F)cc2)Cc2cc(CO)cc(-c3ccc(F)cc3)c2)cc1.Cl>>Cc1ccc(S(=O)(=O)N(Cc2ccc(F)cc2)Cc2cc(COS(C)(=O)=O)cc(-c3ccc(F)cc3)c2)cc1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(N2CCC(O)(CCO)CC2)c(Cl)cc1Cl.O=S(=O)(Cl)c1ccccc1.c1ccncc1>>COc1cc(N2CCC(O)(CCOS(=O)(=O)c3ccccc3)CC2)c(Cl)cc1Cl",
        "output": "197"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccccc1.Cc1nc(N(Cc2ccccc2)Cc2ccccc2)c([N+](=O)[O-])c(NNC(=O)OC(C)(C)C)c1C.[Pt]>>Cc1nc(N(Cc2ccccc2)Cc2ccccc2)c(N)c(NNC(=O)OC(C)(C)C)c1C",
        "output": "269"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.C[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.Nn1cccc1C(=O)Nc1ccccc1>>C[C@H](NC(=O)OC(C)(C)C)C(=O)Nn1cccc1C(=O)Nc1ccccc1",
        "output": "459"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)Cc1nnn(Cc2ccc(OC)cc2)n1.CO.O.[Li+].[OH-]>>COc1ccc(Cn2nnc(CC(=O)O)n2)cc1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COCCOC.COc1ccc(B(O)O)cc1.O.O=C([O-])[O-].O=C1CCCC(=O)C1C(=O)c1ccc(C(F)(F)F)c(Cl)n1.[Cs+].[Cs+]>>COc1ccc(-c2nc(C(=O)C3C(=O)CCCC3=O)ccc2C(F)(F)F)cc1",
        "output": "865"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.COC(=O)c1ccc(CN2C[C@@H]3C[C@H]2CN3)cc1.ClCCl.O=C([O-])O.O=Cc1ccc(OCC(F)(F)C(F)F)cc1.[Na+].[Na+]>>COC(=O)c1ccc(CN2C[C@@H]3C[C@H]2CN3Cc2ccc(OCC(F)(F)C(F)F)cc2)cc1",
        "output": "567"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1Br.Cl.O=C1CCNCC1.O=Cc1ccccc1-c1ccc(Cl)cc1>>O=C1CCN(Cc2ccccc2Br)CC1",
        "output": "248"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NCCCN1CCC(c2cccc(NC(=O)C3CC3)c2)CC1.O=C(O)C1(c2ccc(Cl)cc2Cl)CC1>>O=C(Nc1cccc(C2CCN(CCCNC(=O)C3(c4ccc(Cl)cc4Cl)CC3)CC2)c1)C1CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)c1ccncc1.COc1ccccc1-c1noc(C)c1C(=O)O.ClCCCl.ClCCl.Nc1cc(N2CCNCC2)c(Cl)cc1Cl.O=C(O)C(F)(F)F>>COc1ccccc1-c1noc(C)c1C(=O)N1CCN(c2cc(N)c(Cl)cc2Cl)CC1",
        "output": "975"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)C(C)(C)Oc1ccc(C(=O)O)cc1.CN(C)c1ccncc1.ClCCl.OCc1cn(Cc2ccccc2)nn1>>CC(C)(C)OC(=O)C(C)(C)Oc1ccc(C(=O)OCc2cn(Cc3ccccc3)nn2)cc1",
        "output": "33"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(=O)O[Cu]OC(C)=O.CCN(CC)CC.O=S1(=O)CCN2CCCC(c3ccc(O)cc3)C2=N1.OB(O)c1cccc(Cl)c1>>O=S1(=O)CCN2CCCC(c3ccc(Oc4cccc(Cl)c4)cc3)C2=N1",
        "output": "920"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.COC(=O)CBr.O=C([O-])[O-].O=[N+]([O-])c1cc(O)cc(Br)c1.[K+].[K+]>>COC(=O)COc1cc(Br)cc([N+](=O)[O-])c1",
        "output": "557"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(CO)c2cc(C3OCCO3)nn12.ClC(Cl)Cl.[Mn+4].[O-2].[O-2]>>COc1ccc(C=O)c2cc(C3OCCO3)nn12",
        "output": "520"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.ClCCl.NCC1CC1.O.O=C1CCN(Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1.[Na+]>>Clc1nc(N2CCOCC2)c2sc(CN3CCC(NCC4CC4)CC3)cc2n1",
        "output": "236"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.CCCCCCCCCCCC(=O)Cl.OCCO.c1ccncc1>>CCCCCCCCCCCC(=O)OCCO",
        "output": "126"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cc2c(o1)CN(C)CCC2O.Fc1ccc(Br)c(Br)c1>>Cc1cc2c(o1)CN(C)CCC2Oc1ccc(Br)c(Br)c1",
        "output": "485"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.O=C(NOC1CCCCO1)C1CCc2ccc(Oc3ccnc(Cl)c3)cc2C1>>O=C(NOC1CCCCO1)C1CCc2ccc(Oc3ccncc3)cc2C1",
        "output": "40"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(=O)c1ccc(F)cc1O.CI.O=C([O-])[O-].[K+].[K+]>>COc1cc(F)ccc1C(C)=O",
        "output": "62"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOP(=O)(OCC)c1cc(OC)cc(OC)c1.ClCCl.O=C([O-])[O-].O=C1CCC(=O)N1Br.[Na+].[Na+]>>CCOP(=O)(OCC)c1cc(OC)cc(OC)c1Br",
        "output": "4"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.COc1cc2c(=O)cc[nH]c2cc1I.O=C1CCC(=O)N1Cl>>COc1cc2c(=O)c(Cl)c[nH]c2cc1I",
        "output": "743"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#Cc1ccnc(NC(C)(C)C)n1.C1CCOC1.CCN(CC)CC.Fc1ccc(I)cc1.N#N.[Cu]I>>CC(C)(C)Nc1nccc(C#Cc2ccc(F)cc2)n1",
        "output": "664"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.O.O=[N+]([O-])c1cc2c(cc1Br)CCN2>>CC(C)(C)OC(=O)N1CCc2cc(Br)c([N+](=O)[O-])cc21",
        "output": "827"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.CO.Fc1ccc(Cn2c(NC3CCNCC3)nc3cncnc32)cc1.[H][H].[Pd]>>CC(C)N1CCC(Nc2nc3cncnc3n2Cc2ccc(F)cc2)CC1",
        "output": "187"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1C[C@@H]2CNC[C@@H]2C1.COc1ccc2c(NC(=O)Nc3cncc(Br)n3)ccnc2c1>>COc1ccc2c(NC(=O)Nc3cncc(N4C[C@H]5CN(C(=O)OC(C)(C)C)C[C@H]5C4)n3)ccnc2c1",
        "output": "211"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Br.CS(C)=O.CSc1ccc(N)c(C)c1Cl.O=C([O-])[O-].O=N[O-].[K+].[K+].[Na+]>>CSc1ccc(Br)c(C)c1Cl",
        "output": "373"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.COCCBr.O=C([O-])[O-].O=[N+]([O-])c1cn[nH]c1.[K+].[K+]>>COCCn1cc([N+](=O)[O-])cn1",
        "output": "577"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC2(CCCNC2)C1.CCN(CC)CC.ClCCl>>CC(=O)N1CCCC2(CCN(C(=O)OC(C)(C)C)C2)C1",
        "output": "369"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NCCc1cc(F)c(O)c(F)c1.CS(C)=O.N#Cc1ccc(Cl)nc1.O.[H-].[Na+]>>CC(C)(C)OC(=O)NCCc1cc(F)c(Oc2ccc(C#N)cn2)c(F)c1",
        "output": "516"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Nc1nc2c(s1)-c1c(c(C3CC3)nn1-c1ccc([N+](=O)[O-])cc1Cl)CC2.CC(=O)O.[Fe]>>CC(=O)Nc1nc2c(s1)-c1c(c(C3CC3)nn1-c1ccc(N)cc1Cl)CC2",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)NCCC=O.CO.Cl.NC1CC1.[Na+]>>CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)NCCCNC1CC1",
        "output": "426"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc(Br)c2cc[nH]c12.ClCCl.O=S(=O)(Cl)c1ccccc1.O=S(=O)([O-])O.[Na+].[OH-]>>COc1ccc(Br)c2ccn(S(=O)(=O)c3ccccc3)c12",
        "output": "648"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COCOc1ccc(C#N)cc1OCOC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>COCOc1ccc(CN)cc1OCOC",
        "output": "175"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.O.O=C(O)c1ccc([C@@H]2CC[C@@H](C3CCC4(CC3)OCCO4)CC2)cc1F.O=S(=O)(O)O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1ccc([C@@H]2CC[C@@H](C3CCC4(CC3)OCCO4)CC2)cc1F",
        "output": "72"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)COc1cccc2c1N(C)C(=O)CO2.CO>>CCOC(=O)COc1cccc2c1N(C)CCO2",
        "output": "363"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1=C(CCON)c2cc(F)ccc2/C1=C\\c1ccncc1.O=CCO>>CC1=C(CCON=CCO)c2cc(F)ccc2/C1=C\\c1ccncc1",
        "output": "118"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCCn2c1cc(Cl)nc2=O.OCCc1ccc(Oc2ccc(F)c(F)c2)cc1>>CN1CCCn2c1cc(OCCc1ccc(Oc3ccc(F)c(F)c3)cc1)nc2=O",
        "output": "653"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCCCN1CCOCC1.O=C(C=Cc1c[nH]c2ccccc12)Nc1cccc(C(=O)O)c1>>O=C(C=Cc1c[nH]c2ccccc12)Nc1cccc(C(=O)NCCCN2CCOCC2)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)CC(O)CCN(C)C(=O)OC(C)(C)C.N#Cc1ccc(Cl)cc1O>>CC(C)CC(CCN(C)C(=O)OC(C)(C)C)Oc1cc(Cl)ccc1C#N",
        "output": "846"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC.COC(=O)c1ccc(Br)c(OC2CCCCO2)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1ccc(Br)c(OC2CCCCO2)c1",
        "output": "444"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.NCc1ccc(C(F)(F)F)cc1>>CC(=O)NCc1ccc(C(F)(F)F)cc1",
        "output": "599"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1ccc(Cl)c2occc12.CO.O.[Na+].[OH-]>>O=C(O)c1ccc(Cl)c2occc12",
        "output": "5"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)CCN(C)Cc1ccccc1.[Pd]>>CCOC(=O)CCNC",
        "output": "84"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O.O=C(O)c1ccc(O)nc1.O=S(=O)(O)O.O=[N+]([O-])O>>O=C(O)c1cnc(O)c([N+](=O)[O-])c1",
        "output": "328"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CCCC1=O.COCCBr.Cc1ccc2ccc(O)cc2n1.O=C([O-])[O-].[Cs+].[Cs+]>>COCCOc1ccc2ccc(C)nc2c1",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CN(C)c1ccncc1.COC(=O)C1CCCCC2(CC2)C1O.ClC(Cl)Cl.O=C([O-])O.[Na+]>>COC(=O)C1CCCCC2(CC2)C1OC(C)=O",
        "output": "254"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCO.Clc1ccc2ncc(-c3cc4ccccc4o3)n2n1.NCC(O)CN1CCCC1=O>>O=C1CCCN1CC(O)CNc1ccc2ncc(-c3cc4ccccc4o3)n2n1",
        "output": "241"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cl.ClCCl.NC1CCCC1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)NC1CCCC1",
        "output": "94"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COCCOCC(C)(C)c1ccc(N)cc1.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>COCCOCC(C)(C)c1ccc(N)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CS(C)=O.Cc1cc(F)ccc1-c1cc(Cl)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C([O-])[O-].OC[C@H]1CN2CCNCC2CN1.[K+].[K+]>>Cc1cc(F)ccc1-c1cc(N2CCN3C[C@H](CO)NCC3C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "220"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.N#Cc1ccc(-c2cccc3c2c2ccccc2n3-c2ccc(C(=O)O)c(NCCF)c2)cn1.O.Oc1cccc2[nH]nnc12.[Cl-].[NH4+]>>N#Cc1ccc(-c2cccc3c2c2ccccc2n3-c2ccc(C(N)=O)c(NCCF)c2)cn1",
        "output": "358"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#CCC(O)CC.CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.[Na+]>>C#CCC(CC)OC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(C)c1C",
        "output": "960"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C(=O)OC(C)(C)C)[C@H](Cc1ccc2ccccc2c1)C(=O)O.CN(C)C=O.CN[C@H](Cc1ccccc1)C(=O)NCC(F)(F)F.Cl.ClCCl.On1nnc2cccnc21>>CN(C(=O)OC(C)(C)C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC(F)(F)F",
        "output": "297"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=O.CCCn1nc(C(=O)NC2CCNCC2)c2ccccc21.Cl.O=CO>>CCCn1nc(C(=O)NC2CCN(C)CC2)c2ccccc21",
        "output": "217"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)CCc1cc(Cl)ccc1C(=O)CCCNC(C)=O.N>>CC(=O)NCCCC(=O)c1ccc(Cl)cc1CCC(N)=O",
        "output": "432"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(OC)c(CC(=O)O)c1.ClCCl.O=C(Cl)C(=O)Cl>>COc1ccc(OC)c(CC(=O)Cl)c1",
        "output": "56"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#Cc1ccccc1C=O.C[C@@H](N)c1cccc2ccccc12>>C#Cc1ccccc1CN[C@H](C)c1cccc2ccccc12",
        "output": "683"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.Nc1conc1-c1ccc(O)cc1.O.O=C([O-])[O-].O=S1(=O)CCc2cc(CBr)ccc21.[I-].[K+].[K+]>>Nc1conc1-c1ccc(OCc2ccc3c(c2)CCS3(=O)=O)cc1",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)O.CCN=C=NCCCN(C)C.CN(C)C=O.CN(Cc1ccccc1)C(=O)[C@@H](N)Cc1ccccc1.Cl.On1nnc2ccccc21>>CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)OC(C)(C)C",
        "output": "133"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNCC1.CCOC(C)=O.O=[N+]([O-])c1cccc(Cl)c1Cl>>O=[N+]([O-])c1cccc(Cl)c1N1CCCCC1",
        "output": "105"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C(=O)NCCc1cccs1)(c1ccccc1)c1ccccc1.CI.CN(C)C=O.O.[H-].[Na+]>>CN(CCc1cccs1)C(=O)C(C)(c1ccccc1)c1ccccc1",
        "output": "83"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCO.COC(=O)c1cc(C2CC2)cnc1Nc1ccc2c(-c3ccccc3)cn(C)c2c1.Cl.O.[Na+].[OH-]>>Cn1cc(-c2ccccc2)c2ccc(Nc3ncc(C4CC4)cc3C(=O)O)cc21",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.N#Cc1ccc(Cl)c([N+](=O)[O-])c1.Nc1cccc(-c2ccncn2)c1.O.[H-].[Na+]>>N#Cc1ccc(Nc2cccc(-c3ccncn3)c2)c([N+](=O)[O-])c1",
        "output": "510"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(O)c1cccc2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl.CN(C)C=O.COCCBr.O.[H-].[Na+]>>CCC(OCCOC)c1cccc2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl",
        "output": "95"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.Clc1ncnc2[nH]ccc12.NCC1(c2cc(F)cc(Br)c2)CCNCC1>>NCC1(c2cc(F)cc(Br)c2)CCN(c2ncnc3[nH]ccc23)CC1",
        "output": "540"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCO.NCCS(=O)(=O)N[C@H]1CCCN(C(=O)OCc2ccccc2)C1.O.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)NCCS(=O)(=O)N[C@H]1CCCN(C(=O)OCc2ccccc2)C1",
        "output": "631"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1cc(F)c(F)c(F)c1.Oc1ccc(Cl)cc1.[Cs+].[Cs+]>>O=[N+]([O-])c1cc(F)c(Oc2ccc(Cl)cc2)c(F)c1",
        "output": "564"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.Cl.NCCn1ccc2ncnc(Nc3ccc(Oc4cccc5occc45)c(Cl)c3)c21.O.On1nnc2ccccc21>>CC(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc5occc45)c(Cl)c3)c21",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C(=O)O)c1cnc(C(=O)Nc2ccccc2)nc1.CC1CCN(c2nc(C(F)(F)F)ccc2CN)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F>>CC1CCN(c2nc(C(F)(F)F)ccc2CNC(=O)C(C)c2cnc(C(=O)Nc3ccccc3)nc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1ncoc1-c1ccc([N+](=O)[O-])cc1OC.O.O=S(=O)(O)O.[K+].[OH-]>>COc1cc([N+](=O)[O-])ccc1-c1ocnc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOC(C)=O.CN(C)C=O.Cc1ccccc1.Cc1noc2cc(O)ccc12.O.c1c[nH]cn1>>Cc1noc2cc(O[Si](C)(C)C(C)(C)C)ccc12",
        "output": "746"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)C(=O)Cl.CO.Cl.Cl.NCCc1ccc(O)c(O)c1.O.[NH4+].[OH-].c1ccncc1>>CC(C)(C)C(=O)NCCc1ccc(O)c(O)c1",
        "output": "45"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=c1cc(NC2CCCc3ccccc32)c2cncnc2n1OCc1ccccc1.[C].[H][H].[Pd]>>O=c1cc(NC2CCCc3ccccc32)c2cncnc2n1O",
        "output": "630"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Cl.FC(F)(F)c1ccc(CBr)cc1.O=Cc1ccc(O)c2ccccc12.[H-].[Na+]>>O=Cc1ccc(OCc2ccc(C(F)(F)F)cc2)c2ccccc12",
        "output": "127"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNCC1.CCO.CN1CCN(Cc2ccc(C(=O)Nc3cccc(Nc4cccc5c4NC(=O)C5)c3)cc2)CC1.O=Cc1ccc[nH]1>>CN1CCN(Cc2ccc(C(=O)Nc3cccc(Nc4cccc5c4NC(=O)C5=Cc4ccc[nH]4)c3)cc2)CC1",
        "output": "440"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCS(N)(=O)=O.O=C(O)c1cnn2c(NCc3cccc(F)c3)c(C(=O)N3CCC(c4ccccc4)CC3)cnc12>>CCS(=O)(=O)NC(=O)c1cnn2c(NCc3cccc(F)c3)c(C(=O)N3CCC(c4ccccc4)CC3)cnc12",
        "output": "991"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.N#Cc1ccccc1-c1ccc(C=O)c(C(F)(F)F)c1.[BH4-].[Na+]>>N#Cc1ccccc1-c1ccc(CO)c(C(F)(F)F)c1",
        "output": "356"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1ccc(N2CCN(CCC3CCN(C(=O)OC(C)(C)C)CC3)CC2)cc1.CO.O.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(CCN2CCN(c3ccc(C(=O)O)cc3)CC2)CC1",
        "output": "5"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COc1ncc(Nc2ncc(C(C)CO[Si](C)(C)C(C)(C)C)cc2-c2nc(C)nc(N)n2)cc1F>>COc1ncc(Nc2ncc(C(C)CO)cc2-c2nc(C)nc(N)n2)cc1F",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1CCN(C(=O)c2ccc(N)cc2[N+](=O)[O-])CC1.Cc1ncc(-c2nc(Cl)ncc2F)n1C>>Cc1ncc(-c2nc(Nc3ccc(C(=O)N4CCN(C)CC4)c([N+](=O)[O-])c3)ncc2F)n1C",
        "output": "941"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCCCBr.Fc1ccc2[nH]nc(I)c2c1>>Fc1ccc2c(c1)c(I)nn2CCCCBr",
        "output": "604"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCCBr.CN(C)C=O.Nc1cc(Br)ccc1O.O.O=C([O-])[O-].[K+].[K+]>>Nc1cc(Br)ccc1OCCBr",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.CC1(C)CC(c2ccc(Cl)cc2)c2ccc(O)cc2C1=O.ClCC1CO1.O=C([O-])[O-].[K+].[K+]>>CC1(C)CC(c2ccc(Cl)cc2)c2ccc(OCC3CO3)cc2C1=O",
        "output": "15"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCN1CCN(Cc2cc3cnccc3n2C(=O)OC(C)(C)C)C(=O)C1.ClCCl.O=C(O)C(F)(F)F>>C#CCN1CCN(Cc2cc3cnccc3[nH]2)C(=O)C1",
        "output": "848"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.Cc1ncc(C2=CCNCC2(C)C)cc1[N+](=O)[O-].ClCCCl.ClCCl.O=C(O)Cc1cncc(Br)c1.On1nnc2ccccc21>>O=C(Cc1cncc(Br)c1)N1CCOCC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COc1ccc(F)cc1C=O.[BH4-].[Na+]>>COc1ccc(F)cc1CO",
        "output": "356"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.O=C1Cc2c(cccc2OCCNCc2ccccc2)N1.[Pd]>>NCCOc1cccc2c1CC(=O)N2",
        "output": "561"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.OCCOCCOCCSC(c1ccccc1)(c1ccccc1)c1ccccc1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCCOCCOCCSC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNC1.CN(C)C=O.CS(=O)(=O)c1ccc2c(ccn2-c2ccc(OC3CCN(C(=O)CCl)CC3)cn2)c1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CS(=O)(=O)c1ccc2c(ccn2-c2ccc(OC3CCN(C(=O)CN4CCCC4)CC3)cn2)c1",
        "output": "340"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C/C(=C\\CO)c1ccc(Br)cc1.CC(=O)c1cccc(B(O)O)c1>>CC(=O)c1cccc(-c2ccc(/C(C)=C/CO)cc2)c1",
        "output": "837"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C=CCBr.C=CCC(O)COCc1ccccc1.[H-].[Na+]>>C=CCOC(CC=C)COCc1ccccc1",
        "output": "120"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.CCC1C(=O)N(CC)CCc2cc(N)c(OC)cc21.CS(=O)(=O)N[C@@H]1CCCC[C@H]1Nc1nc(Cl)ncc1Cl.O.O=C([O-])O.[Na+]>>CCC1C(=O)N(CC)CCc2cc(Nc3ncc(Cl)c(N[C@@H]4CCCC[C@H]4NS(C)(=O)=O)n3)c(OC)cc21",
        "output": "808"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCc1c(C(=O)C(C)C)c2ccc(C#N)cc2n1Cc1ccccc1Cl.CO.[BH4-].[Na+]>>CCCc1c(C(O)C(C)C)c2ccc(C#N)cc2n1Cc1ccccc1Cl",
        "output": "449"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1ccc(OCc2nc(-c3ccccc3)oc2C)c(OC)c1.Cl.[Na+].[OH-]>>COc1cc(C(=O)O)ccc1OCc1nc(-c2ccccc2)oc1C",
        "output": "386"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(-n2c(=O)n(OCc3ccccc3)c(=O)c3cc(F)c(N4CCN(C)CC4)cc32)cc1.[Pd]>>COc1ccc(-n2c(=O)n(O)c(=O)c3cc(F)c(N4CCN(C)CC4)cc32)cc1",
        "output": "630"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN1CCCC1CN.COCCOC.Clc1ccc2ncc(-c3ccncc3)n2n1>>CCN1CCCC1CNc1ccc2ncc(-c3ccncc3)n2n1",
        "output": "241"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.COc1cc(CC#N)ccc1O.OCCCC1CCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc(CC#N)ccc1OCCCC1CCCC1",
        "output": "478"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COc1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)nc1.Cl>>COc1ccc(OC2CCNCC2)nc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc(Cc2c(-c3ccsc3)[nH]c3cc(OC)ccc23)n1.[Na+].[OH-]>>COc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccsc3)[nH]c2c1",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCBr.CN(C)C=O.Cl.O=C(C1CCCNC1)N1CCN(c2cccc(C(F)(F)F)c2)CC1.O=C([O-])[O-].[K+].[K+]>>CCN1CCCC(C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)C1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CCOC(C)=O.O.O=Cc1ccc([N+](=O)[O-])cc1[N+](=O)[O-].O=Cc1cccc([N+](=O)[O-])c1[N+](=O)[O-].[Fe]>>Nc1ccc(C=O)c(N)c1",
        "output": "204"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(O)c1cccc(-c2cc(C(F)(F)F)cc3ncn(-c4ccccc4)c23)c1.CI.CN(C)C=O.O.[H-].[H][H].[Na+]>>COC(C)c1cccc(-c2cc(C(F)(F)F)cc3ncn(-c4ccccc4)c23)c1",
        "output": "140"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COCCCOc1ccc([C@@H]2[C@@H](OCc3ccc4c(c3)N(CCCOC)CCO4)CN(C(=O)OCc3ccccc3)C[C@H]2OCCCO)cc1.CS(C)=O.ClCCl.O=S(=O)=O.O=S([O-])O.[K+].c1ccncc1>>COCCCOc1ccc([C@@H]2[C@@H](OCc3ccc4c(c3)N(CCCOC)CCO4)CN(C(=O)OCc3ccccc3)C[C@H]2OCCC=O)cc1",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)C(Cc1ccc(OCCn2c(C(F)(F)F)nc3ccccc32)cc1)OCC.O.[Na+].[OH-]>>CCOC(Cc1ccc(OCCn2c(C(F)(F)F)nc3ccccc32)cc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(COc2cc(F)c(C(=O)NS(C)(=O)=O)cc2C2CC2)CCN(C(=O)OC(C)(C)C)CC1.O=Cc1cc(C(F)(F)F)cc(Cl)c1F>>CC1(COc2cc(F)c(C(=O)NS(C)(=O)=O)cc2C2CC2)CCN(Cc2cc(C(F)(F)F)cc(Cl)c2F)CC1",
        "output": "935"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)O.CC1CC(=O)NN=C1c1ccc(NCC(C)(C)N)cc1.Clc1ccc(Cl)c(OCC2CO2)c1>>CC1CC(=O)NN=C1c1ccc(NCC(C)(C)NCC(O)COc2cc(Cl)ccc2Cl)cc1",
        "output": "16"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)CC(CC(C)C)C(=O)O.CN1CCOCC1.Cl.Cl.ClCCCl.NCc1ccc(-c2ccccn2)s1.On1nnc2ccccc21>>CCOC(=O)CC(CC(C)C)C(=O)NCc1ccc(-c2ccccn2)s1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)Cc1cnc(Cc2ccc(NC(=O)OCc3ccccc3)cc2)nc1N(C)C.[Na+].[OH-]>>CN(C)c1nc(Cc2ccc(NC(=O)OCc3ccccc3)cc2)ncc1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN.CN(C)C=O.N#Cc1c(F)cccc1F.O>>CNc1cccc(F)c1C#N",
        "output": "572"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.CN1CCc2nc(NC(=O)c3cccc(C4CCCN4)c3)sc2C1.COc1ccc(C(=O)O)cc1OC.Cl.Cl.O=C(n1ccnc1)n1ccnc1>>COc1ccc(C(=O)N2CCCC2c2cccc(C(=O)Nc3nc4c(s3)CN(C)CC4)c2)cc1OC",
        "output": "794"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCOC(=O)Cc1ccsc1.ClC(Cl)Cl.O.O=C1CCC(=O)N1Br>>CCOC(=O)Cc1ccsc1Br",
        "output": "807"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(CCl)CN1CCOCC1.Cc1cccc2c(O)c(-c3ccccc3)c(=O)oc12>>Cc1cccc2c(OCC(C)CN3CCOCC3)c(-c3ccccc3)c(=O)oc12",
        "output": "74"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cn1ccc2cccc(C(=O)O)c21.O=S(Cl)Cl>>COC(=O)c1cccc2ccn(C)c12",
        "output": "521"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br[Ni]Br.CN1CCCC1=O.O.Oc1cccc(-c2nc(-c3ccnc(Cl)c3)c3sccc3n2)c1.[C-]#N.[Na+]>>N#Cc1cc(-c2nc(-c3cccc(O)c3)nc3ccsc23)ccn1",
        "output": "726"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCN(c2ccc(Nc3nc(N)c(C(=O)c4ccc(Cl)c([N+](=O)[O-])c4)s3)cc2)CC1.OC1CCNCC1>>CN1CCN(c2ccc(Nc3nc(N)c(C(=O)c4ccc(N5CCC(O)CC5)c([N+](=O)[O-])c4)s3)cc2)CC1",
        "output": "105"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOc1cc(C=O)cc2c1OC(C)C(=O)N2.CNC(=O)c1ccc(N2CCNCC2)c(C)c1.Cl.Cl>>CCOc1cc(CN2CCN(c3ccc(C(=O)NC)cc3C)CC2)cc2c1OC(C)C(=O)N2",
        "output": "567"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCC(C)NC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN)c1=O.O=C(Cl)N1CCOCC1>>COCC(C)NC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCNC(=O)N2CCOCC2)c1=O",
        "output": "454"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CN(C)C=O.CO.COc1cc(Br)cc(C(=O)O)c1.ClCCl>>COC(=O)c1cc(Br)cc(OC)c1",
        "output": "195"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COCCOC.COc1cccc(B(O)O)c1.Nc1cnc(Br)cn1.O.O=C([O-])[O-].[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cccc(-c2cnc(N)cn2)c1",
        "output": "876"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)C(=O)Cl.CC(C)(C)N.CCN(CC)CC.CCOCC>>CC(C)(C)NC(=O)C(C)(C)C",
        "output": "45"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)c1cnn(C(C)C)c1C(F)(F)F.Cc1ccccc1.Cl.[H-]>>CC(C)n1ncc(CO)c1C(F)(F)F",
        "output": "471"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCc1nc(CC)c(-c2ccc3c(c2)CCO3)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1nc(CC)c(-c2ccc3c(c2)CCO3)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCOC(=O)c1cnn2ccc(O)nc12.O=P(Cl)(Cl)Cl>>CCOC(=O)c1cnn2ccc(Cl)nc12",
        "output": "25"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cn1c(=O)oc2ccc(O[Si](C)(C)C(C)(C)C)cc21.[F-]>>Cn1c(=O)oc2ccc(O)cc21",
        "output": "754"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=Cc1ccccc1-c1ccncc1.[BH4-].[Na+]>>OCc1ccccc1-c1ccncc1",
        "output": "356"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(CC(C)(C)C)c2ncnn12.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(CC(C)(C)C)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COc1ccc(O)cc1.Clc1ncnc2ccccc12.[H-].[Na+]>>COc1ccc(Oc2ncnc3ccccc23)cc1",
        "output": "890"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cc2cc(Oc3ccc(-c4cc(C(F)(F)F)cc(=O)n4Cc4ccc(C)cc4C)cc3)ccc2[nH]1.Cl.O.[Li+].[OH-]>>Cc1ccc(Cn2c(-c3ccc(Oc4ccc5[nH]c(C(=O)O)cc5c4)cc3)cc(C(F)(F)F)cc2=O)c(C)c1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCN=C=O.CCN(CC)CC.Cc1c(CN)[nH]c2ccccc2c1=O.Cl.Cl.ClC(Cl)Cl>>CCCCCNC(=O)NCc1[nH]c2ccccc2c(=O)c1C",
        "output": "244"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN.COC(=O)[C@H](C)Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc4nccs4)c3)c12>>CNC(=O)[C@H](C)Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc4nccs4)c3)c12",
        "output": "392"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Cl.CN1CCCC1=O.COC(=O)C=Cc1ccc(N)cc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl.O.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)C=Cc1ccc(NC(C)=O)cc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl",
        "output": "9"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cc1cccc(Br)c1.CCOC(C)=O.CN1CCCC1=O.N#C[Cu].O.[NH4+].[OH-]>>CCOC(=O)Cc1cccc(C#N)c1",
        "output": "531"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.O.O=C(O)c1cccc2cc(O)ccc12.O=S(=O)(O)O>>CC(=O)Oc1ccc2c(C(=O)O)cccc2c1",
        "output": "46"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=C(O)CCc1cccc(O)c1.O=S(Cl)Cl>>CCOC(=O)CCc1cccc(O)c1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.Cl.NC(=O)c1ccnc(N2CCC3(CC2)OCCO3)n1>>NC(=O)c1ccnc(N2CCC(=O)CC2)n1",
        "output": "251"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.COC(=O)[C@@H]1CC[C@@H](NCCCc2ccccc2)CC1.Cl.F[B-](F)(F)F.N#Cc1ccc(N2CCC(C(=O)O)CC2)cc1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>COC(=O)[C@@H]1CC[C@@H](N(CCCc2ccccc2)C(=O)C2CCN(c3ccc(C#N)cc3)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1ccc(OCCC(O)CC)c(C(=O)c2ccccc2)c1.CS(=O)(=O)Cl.ClCCl>>CCc1ccc(OCCC(CC)OS(C)(=O)=O)c(C(=O)c2ccccc2)c1",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCC1CC1.C#Cc1cccc(O)c1.CC(C)=O.CCOCC.O=C([O-])[O-].[Cs+].[Cs+].[I-].[Na+]>>C#Cc1cccc(OCC2CC2)c1",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.CC(C)(C)OC(=O)NCCC(=O)O.O=C(CBr)c1cccnc1>>CC(C)(C)OC(=O)NCCC(=O)OCC(=O)c1cccnc1",
        "output": "523"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)OB(c2cn[nH]c2)OC1(C)C.Nc1nnc(-c2cc3c(s2)-c2ccc(Br)cc2OCC3)n1-c1ccccc1Cl>>Nc1nnc(-c2cc3c(s2)-c2ccc(-c4cn[nH]c4)cc2OCC3)n1-c1ccccc1Cl",
        "output": "971"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(O)c(C(=O)C2CC=CC2)c1.Cl.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>COc1ccc(OS(=O)(=O)C(F)(F)F)c(C(=O)C2CC=CC2)c1",
        "output": "731"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CO.Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCN)c1.ClC(Cl)Cl.O=Cc1ccc(-c2cccnc2)s1.O=S(=O)([O-])[O-].[BH3-]C#N.[Mg+2].[Na+]>>Cc1cc(C)cc(-c2[nH]c3ccc(C(C)(C)C(=O)N4C5CCC4CC5)cc3c2CCNCc2ccc(-c3cccnc3)s2)c1",
        "output": "691"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.N=C(NO)c1ccc(CC(C(=O)O)c2cccc(C(F)(F)F)c2)cc1.O=C(Cl)C(=O)Cl>>COC(=O)C(Cc1ccc(C(=N)NO)cc1)c1cccc(C(F)(F)F)c1",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COc1cc(-c2ccc(F)cc2F)c(C2CC2)cc1CN1CC2(CC(N3CCC(C)(C(=O)[O-])CC3)=NO2)C1.Cl.[Na+].[OH-]>>COc1cc(-c2ccc(F)cc2F)c(C2CC2)cc1CN1CC2(CC(N3CCC(C)(C(=O)O)CC3)=NO2)C1",
        "output": "151"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCCNS(=O)(=O)CCCC=CCC[C@@H]1Cc2cc(O)ccc2[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12.CCOC(C)=O.[Pd]>>CCCCCCCNS(=O)(=O)CCCCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12",
        "output": "143"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.NS(=O)(=O)c1cnc(OCC2(F)CCC3(CC2)OCCO3)c(Cl)c1.O.c1cc[nH+]cc1>>NS(=O)(=O)c1cnc(OCC2(F)CCC(=O)CC2)c(Cl)c1",
        "output": "251"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2cccs2)nc2ccccc12)C1CCCCC1.C[C@H](O)C(=O)O>>C[C@H](O)C(=O)N1CCN(Cc2c(-c3cccs3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Clc1cc(N2CCOc3ccccc3C2)nc2ccccc12.NCCN>>NCCNc1cc(N2CCOc3ccccc3C2)nc2ccccc12",
        "output": "78"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.COc1ccc(S(=O)(=O)C(F)F)cc1N.Cc1ccc(N=C=O)cc1>>COc1ccc(S(=O)(=O)C(F)F)cc1NC(=O)Nc1ccc(C)cc1",
        "output": "473"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NNc1ccc(I)cc1.O=Cc1cc(O)c(O)cc1O>>Oc1cc(O)c(C=NNc2ccc(I)cc2)cc1O",
        "output": "167"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCCCCCCc1cc2ccc(C(=O)O)cc2[nH]1.CCO.Cl>>CCCCCCCCCCCCc1cc2ccc(C(=O)OCC)cc2[nH]1",
        "output": "47"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.COc1cc([N+](=O)[O-])ccc1OCC(C)(C)N1CCCC1.[Pd]>>COc1cc(N)ccc1OCC(C)(C)N1CCCC1",
        "output": "202"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C([O-])O.O=P(Cl)(Cl)Cl.O=c1[nH]c(C(F)(F)F)nc(-c2ccccc2)c1-c1ccccc1.[Na+]>>FC(F)(F)c1nc(Cl)c(-c2ccccc2)c(-c2ccccc2)n1",
        "output": "14"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N.CC(C)NC(C)C.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cn1nc(N2CCC(CN3C(=O)CN(S(=O)(=O)c4ccc5c(Cl)c[nH]c5c4)CC3C(=O)O)CC2)ccc1=O.F[B-](F)(F)F>>CC(C)NC(=O)C1CN(S(=O)(=O)c2ccc3c(Cl)c[nH]c3c2)CC(=O)N1CC1CCN(c2ccc(=O)n(C)n2)CC1",
        "output": "216"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COc1cccc(C(=O)c2ccc(C(C)C)cc2)c1[N+](=O)[O-].[Ni]>>COc1cccc(C(=O)c2ccc(C(C)C)cc2)c1N",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.CP(C)(=O)c1ccc(N)cc1.Clc1ncc(Cl)c(Cl)n1.O=C([O-])O.O=C([O-])[O-].[K+].[K+].[Na+]>>CP(C)(=O)c1ccc(Nc2nc(Cl)ncc2Cl)cc1",
        "output": "352"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCOC(C)=O.COc1ccc(CNS(=O)(=O)Cc2ccc(CO)cc2)c(OC)c1.CS(=O)(=O)Cl.ClCCl>>COc1ccc(CNS(=O)(=O)Cc2ccc(COS(C)(=O)=O)cc2)c(OC)c1",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CN1CCOCC1.Nc1ccc2c(c1)B(O)OC2.O=[N+]([O-])c1cc(OCc2ccccc2)ccc1S(=O)(=O)Cl>>O=[N+]([O-])c1cc(OCc2ccccc2)ccc1S(=O)(=O)Nc1ccc2c(c1)B(O)OC2",
        "output": "68"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.C[C@H](N)c1nc2ccccc2n1-c1ccccc1.Cl.Nc1cc(Cl)ncn1>>C[C@H](Nc1cc(N)ncn1)c1nc2ccccc2n1-c1ccccc1",
        "output": "166"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCN(C(=O)c2ncn(C3CCCCC34CO4)c2-c2ccccc2)[C@H](Cc2ccccc2)C1.CCN.[Li+].[O-][Cl+3]([O-])([O-])[O-]>>CCNCC1(O)CCCCC1n1cnc(C(=O)N2CCN(C(=O)OC(C)(C)C)C[C@H]2Cc2ccccc2)c1-c1ccccc1",
        "output": "16"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COc1ccc(C[C@H](NC(=O)[C@H](C)NS(=O)(=O)c2ccccc2)C(=O)OCc2ccccc2)cc1.[OH-].[OH-].[Pd+2]>>COc1ccc(C[C@H](NC(=O)[C@H](C)NS(=O)(=O)c2ccccc2)C(=O)O)cc1",
        "output": "186"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.COc1cc([N+](=O)[O-])ccc1N1CC[C@@H](O)C1.O.[H-].[Na+]>>COc1cc([N+](=O)[O-])ccc1N1CC[C@@H](OC)C1",
        "output": "140"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1onc2c1c(=O)n(C1CCCC(C(=O)O)C1)c1cnccc21.Cl.NCc1ccccc1.On1nnc2cccnc21>>Cc1onc2c1c(=O)n(C1CCCC(C(=O)NCc3ccccc3)C1)c1cnccc21",
        "output": "599"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)c1ccc(CNCCc2cccc(OC(F)F)c2)cc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O.O=C(O)c1cc(Cl)cc2cc[nH]c12>>CC(C)(C)c1ccc(CN(CCc2cccc(OC(F)F)c2)C(=O)c2cc(Cl)cc3cc[nH]c23)cc1",
        "output": "893"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)C(C)n1ccc2cc(O)ccc21.ClCCl.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.OCCCOc1ccc(-c2nc3c(s2)CCCC3)cn1.[Li+].[OH-].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C(=O)O)n1ccc2cc(OCCCOc3ccc(-c4nc5c(s4)CCCC5)cn3)ccc21",
        "output": "928"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc(C(=O)O)cc(OC)c1OC.CS(C)=O.Nc1nc(N)c2cc(CBr)ccc2n1.O.O=C([O-])[O-].[Br-].[K+].[K+].[K+]>>COc1cc(C(=O)OCc2ccc3nc(N)nc(N)c3c2)cc(OC)c1OC",
        "output": "403"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Cc1c(-c2ccc(F)nc2)nc2cc(F)cc(F)c2c1Cl.Cl.FC1(F)CCNCC1.O.O=C([O-])[O-].[K+].[K+]>>Cc1c(-c2ccc(N3CCC(F)(F)CC3)nc2)nc2cc(F)cc(F)c2c1Cl",
        "output": "756"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)CC2(CC2)Oc2c(C3CC3)cc(C#C[Si](C)(C)C)cc21.CCCCCC.CCOC(C)=O.CO.O=C([O-])[O-].[K+].[K+]>>C#Cc1cc(C2CC2)c2c(c1)C(C)(C)CC1(CC1)O2",
        "output": "337"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.C1CCOC1.N#Cc1cc(Br)c2[nH]c(C(F)(F)F)cc2c1>>NCc1cc(Br)c2[nH]c(C(F)(F)F)cc2c1",
        "output": "175"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCC(C)(C)c1ccc(Br)c(O)c1.OB(O)c1cccnc1>>CCCCCCC(C)(C)c1ccc(-c2cccnc2)c(O)c1",
        "output": "899"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CO.COC(=O)Cn1c(C2CCN(C(=O)N(C)O)CC2)nc(-c2ccc(OC)cc2)c1-c1ccc(OC)cc1.O.O.[Li+].[OH-]>>COc1ccc(-c2nc(C3CCN(C(=O)N(C)O)CC3)n(CC(=O)O)c2-c2ccc(OC)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCNC1CCc2ncsc2C1.O=CCCCNC(=O)NC1Cc2ccccc2C1>>CCCN(CCCCNC(=O)NC1Cc2ccccc2C1)C1CCc2ncsc2C1",
        "output": "484"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.NC(=O)Cc1nccnc1CCc1nc(Nc2ccc(C3CCNCC3)cc2)ncc1C(F)(F)F.[Na+]>>CN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4nccnc4CC(N)=O)n3)cc2)CC1",
        "output": "217"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cl.Nc1ccccc1C(=O)O.O=C(Cl)COc1ccccc1.[Na+].[OH-]>>O=C(COc1ccccc1)Nc1ccccc1C(=O)O",
        "output": "9"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCCOc1c(CNC(=O)OC(C)(C)C)n(CC(C)C)c(=O)c2ccc(-c3nc(C)c(C(=O)OCC)s3)cc12.CCO.Cl.O.[Na+].[OH-]>>CCCCOc1c(CNC(=O)OC(C)(C)C)n(CC(C)C)c(=O)c2ccc(-c3nc(C)c(C(=O)O)s3)cc12",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cc1c(Cl)cc([N+](=O)[O-])cc1Cl.Cl[Sn]Cl.O.O>>Cc1c(Cl)cc(N)cc1Cl",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CC1C=C(C(=O)O)N2C(=O)C(N)[C@H]2S1.CCOC(C)=O.CN(C)C=O.CON=C(C(=O)O)c1csc(N)n1.C[Si](C)(C)CC(N)=O.O.O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+]>>CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=CC(C)S[C@H]12)c1csc(N)n1",
        "output": "587"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COCOCCCCCCCCCCCCCCCCN1C(=O)c2ccccc2C1=O.NN.O>>COCOCCCCCCCCCCCCCCCCN",
        "output": "242"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCCCCBr.CN(C)C=O.CN(c1ccc(O)cc1)S(=O)(=O)c1ccc(C(F)(F)F)cc1.[Cl-].[H-].[NH4+].[Na+]>>CN(c1ccc(OCCCCBr)cc1)S(=O)(=O)c1ccc(C(F)(F)F)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O.O=C(NCCNC(=O)[C@@H]1CC[C@@H](C(=O)c2ccccc2)CC1)c1cn(-c2ccccc2)nc1C(F)(F)F.[BH4-].[Na+]>>O=C(NCCNC(=O)[C@@H]1CC[C@@H](C(O)c2ccccc2)CC1)c1cn(-c2ccccc2)nc1C(F)(F)F",
        "output": "24"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NC1CCOCC1CO.CCCCP(CCCC)CCCC.Cc1ccccc1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.Oc1ccc(-c2ccc(Cl)cn2)cc1.[Na+].[OH-]>>CC(C)(C)OC(=O)NC1CCOCC1COc1ccc(-c2ccc(Cl)cn2)cc1",
        "output": "550"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(CCNCC2CC2)cc1OC.O=C(O)c1ncccc1Br>>COc1ccc(CCN(CC2CC2)C(=O)c2ncccc2Br)cc1OC",
        "output": "605"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.COc1cccc(CCl)c1.O.OCCO.[H-].[I-].[Na+]>>COc1cccc(COCCO)c1",
        "output": "208"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCO.CN(C)C=O.ClCCl.O.O=C(Cl)C(=O)Cl.O=C(O)C(Cl)(Cl)CCCCCCCCCCCCBr>>CCOC(=O)C(Cl)(Cl)CCCCCCCCCCCCBr",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.COc1ccc(C(=O)O)cc1Br.Cl.ClCCl.Nc1cnc2c(c1)CN(Cc1ccccc1)CC2.On1nnc2ccccc21>>COc1ccc(C(=O)Nc2cnc3c(c2)CN(Cc2ccccc2)CC3)cc1Br",
        "output": "759"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccc(C#CC(=O)O)cc12.CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NCc2cccc(Cl)c2F)c2ccc(C#C[Si](C)(C)C)cc12.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>C#Cc1ccc2c(c1)c(C(C)=O)cn2CC(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cccc(Cl)c1F",
        "output": "337"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOc1cc(-c2cc(N3CCOC[C@H]3C(C)C)nc(N)n2)cc(F)c1C#N.NN.O>>CCOc1cc(-c2cc(N3CCOC[C@H]3C(C)C)nc(N)n2)cc2[nH]nc(N)c12",
        "output": "945"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)c1cc(C(C)C)c(Br)c(C(C)C)c1.Cl.O=C=O>>CC(C)c1cc(C(C)C)c(C(=O)O)c(C(C)C)c1",
        "output": "654"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1onc(-c2ccccc2)c1-c1cn(-c2ccc([N+](=O)[O-])cc2)c(COCc2ccccc2)n1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.O=S(=O)(O)C(F)(F)F.[Na+]>>Cc1onc(-c2ccccc2)c1-c1cn(-c2ccc([N+](=O)[O-])cc2)c(CO)n1",
        "output": "178"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#C[Si](C)(C)C.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Clc1cc2cc(Br)ccc2cn1.I[Cu]I.[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C[Si](C)(C)C#Cc1ccc2cnc(Cl)cc2c1",
        "output": "671"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(CCN4CCOCC4)c3)n2)c1.Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(OCCCN4CCOCC4)c3)n2)c1.O=C(Cl)Cc1ccccc1.O=C(Cl)c1c(F)cccc1F>>O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(CCN4CCOCC4)c3)n2)c1",
        "output": "9"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)CC1CCCO1.NN.O>>NNC(=O)CC1CCCO1",
        "output": "164"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(C(F)(F)F)cc1N.COc1ccc(-c2cccc(C(=O)CC(=O)OC(C)(C)C)c2)cn1>>COc1ccc(-c2cccc(C(=O)CC(=O)Nc3cc(C(F)(F)F)ccc3NC(=O)OC(C)(C)C)c2)cn1",
        "output": "929"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOCC.CO.COC(=O)c1ccc(OCc2ccncc2)c(OC)c1.[K+].[OH-]>>COc1cc(C(=O)O)ccc1OCc1ccncc1",
        "output": "222"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)N.CCO.CCOC(=O)C(F)Cl.OCCO>>CC(C)NC(=O)C(F)Cl",
        "output": "64"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.N#Cc1c(Oc2cccc(N)c2)ccc2nc(NC(=O)C3CC3)sc12.O=C(O)Cc1cccc(C(F)(F)F)c1.c1ccncc1>>N#Cc1c(Oc2cccc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)ccc2nc(NC(=O)C3CC3)sc12",
        "output": "365"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCNC(=O)[O-].Cc1ccc2c(c1)C1CNCC1C2C.ClCCl.O.O=C1CCC(=O)N1Br>>Cc1cc2c(cc1Br)C(C)C1CNCC21",
        "output": "4"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC(=O)N(C)C.CCOC(C)=O.Cc1cc(C)cc(-c2cncc(-c3nc4c(C)cc(C)cc4[nH]3)c2N2CCC(N)CC2)c1.Cc1cc(C)cc(-c2cncc(-c3nc4c(C)cc(C)cc4[nH]3)c2N2CCC(NC(=O)OC(C)(C)C)CC2)c1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=S([O-])O.[Na+].[Na+].[OH-]>>Cc1cc(C)cc(-c2c[n+]([O-])cc(-c3nc4c(C)cc(C)cc4[nH]3)c2N2CCC(NC(=O)OC(C)(C)C)CC2)c1",
        "output": "262"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCOc1cccc(-c2noc3ccsc23)c1.CC#N.CC1CCNCC1.O=C([O-])[O-].[K+].[K+]>>CC1CCN(CCOc2cccc(-c3noc4ccsc34)c2)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.COC(=O)CCn1c(=O)c2c(nc(N3CCCCC3)n2Cc2c(F)cccc2Cl)n(C(C)C)c1=O.O.[Li+].[OH-]>>CC(C)n1c(=O)n(CCC(=O)O)c(=O)c2c1nc(N1CCCCC1)n2Cc1c(F)cccc1Cl",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCCCCCCBr.N#Cc1cccc(O)c1.[K]>>N#Cc1cccc(OCCCCCCBr)c1",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.C=Cc1ncc(CO[Si](C)(C)C(C)(C)C)cc1Cl.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>C=Cc1ncc(CO)cc1Cl",
        "output": "708"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C1COCCO1.CCN.Cc1cc(F)c(C(=O)NC2CC2)cc1-n1ccnc(NC2(c3ccccc3OCCCl)CC2)c1=O>>CCNCCOc1ccccc1C1(Nc2nccn(-c3cc(C(=O)NC4CC4)c(F)cc3C)c2=O)CC1",
        "output": "279"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN(C)C=O.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])[O-].O=C1NC(=O)C(Cc2ccc(O)cc2)S1.O=Cc1ccc(F)cc1.[Cs+].[Cs+]>>O=Cc1ccc(Oc2ccc(CC3SC(=O)NC3=O)cc2)cc1",
        "output": "564"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CN[C@H](C)c1oc2ccccc2c1C.Cl.ClCCCl.O.O=C(O)/C=C/c1cnc2c(c1)COCC(=O)N2.On1nnc2ccccc21>>Cc1c([C@@H](C)N(C)C(=O)/C=C/c2cnc3c(c2)COCC(=O)N3)oc2ccccc12",
        "output": "811"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)Oc2ccc(OCCCCOc3c(Cl)cc(OCc4ccccc4)cc3Cl)cc2O1.CCO.[Pd]>>CC1(C)Oc2ccc(OCCCCOc3c(Cl)cc(O)cc3Cl)cc2O1",
        "output": "23"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)C(=O)Nc1ccccc1-c1c2nc(c(-c3ccccc3NC(=O)C(C)(C)C)c3cc(C=O)c([nH]3)c(-c3ccccc3NC(=O)C(C)(C)C)c3nc(c(-c4ccccc4NC(=O)C(C)(C)C)c4ccc1[nH]4)C=C3)C=C2.CO.ClCCl.O.[BH4-].[Na+]>>CC(C)(C)C(=O)Nc1ccccc1-c1c2nc(c(-c3ccccc3NC(=O)C(C)(C)C)c3cc(CO)c([nH]3)c(-c3ccccc3NC(=O)C(C)(C)C)c3nc(c(-c4ccccc4NC(=O)C(C)(C)C)c4ccc1[nH]4)C=C3)C=C2",
        "output": "476"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccccc1-c1cncnc1.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+].[Na+].[OH-]>>Cc1ccc([N+](=O)[O-])cc1-c1cncnc1",
        "output": "103"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCOc1cc([N+](=O)[O-])ccc1C(=O)OCC.N.[Zn]>>CCCOc1cc(N)ccc1C(=O)OCC",
        "output": "772"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)Cl.Cl.NO.NO.O=C(O)CCCc1ccccc1.[K+].[OH-]>>O=C(CCCc1ccccc1)NO",
        "output": "480"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "NC(N)=O.Nc1ccc(Cl)c(S(=O)(=O)N2CCOCC2)c1O.O=C=Nc1ccccc1Br>>O=C(Nc1ccccc1Br)Nc1ccc(Cl)c(S(=O)(=O)N2CCOCC2)c1O",
        "output": "473"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(C(=O)OC)n1c(=NC(=O)c2ccc(C)cc2)sc2cc(C(=O)N3CCC3)ccc21.CO.O.[Na+].[OH-]>>CCC(C(=O)O)n1c(=NC(=O)c2ccc(C)cc2)sc2cc(C(=O)N3CCC3)ccc21",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Oc1c(C)c(-c2cc3ccc(O)cc3o2)oc(=O)c1C.CCOC(C)=O.ClCCl.O=C([O-])O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.[Na+].c1ccncc1>>CC(=O)Oc1c(C)c(-c2cc3ccc(OS(=O)(=O)C(F)(F)F)cc3o2)oc(=O)c1C",
        "output": "731"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1cc2c(cc1C)C(=O)CC2.[BH4-].[Na+]>>Cc1cc2c(cc1C)C(O)CC2",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOP(=O)(COCCOn1cnc2c(N)ncnc21)OCC.C[Si](C)(C)Br.ClCCl>>Nc1ncnc2c1ncn2OCCOCP(=O)(O)O",
        "output": "535"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1CCNCC1.CNC(=O)c1cnc(Cl)cc1-c1ccccc1C.[Na+].[OH-]>>CNC(=O)c1cnc(N2CCN(C)CC2)cc1-c1ccccc1C",
        "output": "220"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)COc1ccc2c(c1)CC(N)C2.O=S(=O)(Cl)c1cc(S(=O)(=O)c2ccccc2)ccc1C(F)(F)F>>COC(=O)COc1ccc2c(c1)CC(NS(=O)(=O)c1cc(S(=O)(=O)c3ccccc3)ccc1C(F)(F)F)C2",
        "output": "43"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.Cl[Sn]Cl.Nc1cc(C(F)(F)F)c(C(F)(F)F)cc1[N+](=O)[O-]>>Nc1cc(C(F)(F)F)c(C(F)(F)F)cc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.NC1CC1.O=C=Nc1ccc(Br)cc1>>O=C(Nc1ccc(Br)cc1)NC1CC1",
        "output": "35"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)[C@@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1.Cl.[Li+].[OH-]>>O=C(O)[C@@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)c1c[nH]c(-c2ccc(F)cc2)c1-c1ccncc1.Cc1ccccc1.[H-]>>OCc1c[nH]c(-c2ccc(F)cc2)c1-c1ccncc1",
        "output": "383"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1cccc(Br)c1)C2.F[C@@H]1CCNC1>>COC[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1cccc(N3CC[C@@H](F)C3)c1)C2",
        "output": "294"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CCNCC2)nc1C(F)(F)F.O=C=NCc1ccc(Cl)c(Cl)c1>>CCOC(=O)c1cc(C#N)c(N2CCN(C(=O)NCc3ccc(Cl)c(Cl)c3)CC2)nc1C(F)(F)F",
        "output": "583"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCOC(=O)c1cn(-c2ccc(F)cc2)c2c(Cl)c(Cl)ncc2c1=O.O.O=S(=O)(O)O>>O=C(O)c1cn(-c2ccc(F)cc2)c2c(Cl)c(Cl)ncc2c1=O",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)N.CC1(C)Cc2cc(C(=O)O)sc2C1.CCN(CC)CC.ClCCl.O=S(Cl)Cl>>CC1(C)Cc2cc(C(=O)NC(C)(C)C)sc2C1",
        "output": "736"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Nc1nc2cnc(-c3cccc(C(=O)O)c3)cn2n1.O=S(Cl)Cl>>CCOC(=O)c1cccc(-c2cn3nc(N)nc3cn2)c1",
        "output": "33"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCC.CCOC(C)=O.CS(=O)(=O)OCC1(c2cccc3ccccc23)CCCC1.CS(C)=O.[C-]#N.[Na+]>>N#CCC1(c2cccc3ccccc23)CCCC1",
        "output": "705"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(n2cnc3ccc(Br)cc32)C1.ClCCl.O=C(O)C(F)(F)F>>Brc1ccc2ncn(C3CCNC3)c2c1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)c1ccncc1.Cl.NS(=O)(=O)c1nc2cc(O)ccc2s1.O=C(Cl)CC1CCCC1>>NS(=O)(=O)c1nc2cc(OC(=O)CC3CCCC3)ccc2s1",
        "output": "111"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCOCC1.COC(=O)c1cn(C(=O)OC(C)(C)C)c2nccc(CN[C@H](CC(F)(F)F)C(=O)O)c12.F[P-](F)(F)(F)(F)F.NC1CCCC1>>COC(=O)c1cn(C(=O)OC(C)(C)C)c2nccc(CN[C@H](CC(F)(F)F)C(=O)NC3CCCC3)c12",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)CCC(C)(C)c2cc(CCl)ccc21.CS(C)=O.O=Cc1cccc(O)c1O.[H-].[Na+]>>CC1(C)CCC(C)(C)c2cc(COc3c(O)cccc3C=O)ccc21",
        "output": "49"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COC(=O)c1ccc(Br)cc1N1CCCS1(=O)=O.[Na+].[OH-]>>O=C(O)c1ccc(Br)cc1N1CCCS1(=O)=O",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CN([C@@H]2CC[C@@H](CO)CC2)c2c(cnc3c2ccn3COCC[Si](C)(C)C)C1=O.CS(C)=O.O=C(O)c1ccccc1I(=O)=O.O=C([O-])O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>CN1CN([C@@H]2CC[C@@H](C=O)CC2)c2c(cnc3c2ccn3COCC[Si](C)(C)C)C1=O",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(N)CNC(=O)OC(C)(C)C.CN(C)C=O.N#Cc1ccc(Cl)nc1.O.O=C([O-])O.[K+]>>CC(CNC(=O)OC(C)(C)C)Nc1ccc(C#N)cn1",
        "output": "70"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#Cc1cccc(Nc2ncnc3ccc(I)cc23)c1.C#Cc1ccccn1.CCNCC.CN(C)C=O>>C#Cc1cccc(Nc2ncnc3ccc(C#Cc4ccccn4)cc23)c1",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cl[Pd]Cl.O=C1CCc2cc(Br)ccc21.[K+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC1(C)OB(c2ccc3c(c2)CCC3=O)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=C(O)Cc1cc(Br)cc(Br)c1O.O=S(=O)(O)O>>COC(=O)Cc1cc(Br)cc(Br)c1O",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.C[S-].O=C(O)C(CC1CCCCO1)c1ccc(F)c(C(F)(F)F)c1.[H-].[Na+].[Na+]>>CSc1ccc(C(CC2CCCCO2)C(=O)O)cc1C(F)(F)F",
        "output": "503"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1cc(OC)ccc1C.ClC(Cl)(Cl)Cl.ClCCl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)c1cc(OC)ccc1CBr",
        "output": "545"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccccc1.CN(C)C=O.Oc1ccc2cc(Br)ccc2c1.[Cl-].[H-].[NH4+].[Na+]>>Brc1ccc2cc(OCc3ccccc3)ccc2c1",
        "output": "127"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.C[C@H](Br)C(=O)O.Cc1cccc(N)c1.ClCCl.O.On1nnc2ccccc21>>Cc1cccc(NC(=O)[C@H](C)Br)c1",
        "output": "365"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cc(OCCCC2CCNCC2)cc(C)c1C(=O)O.Cl.Fc1ccc(Cl)cn1>>Cc1cc(OCCCC2CCN(c3ccc(Cl)cn3)CC2)cc(C)c1C(=O)O",
        "output": "756"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CC#N.CC(=O)c1ccc(O)c([N+](=O)[O-])c1O.COC(C)(C)C.O.O=C([O-])O.[Na+]>>CC(=O)c1ccc(OCc2ccccc2)c([N+](=O)[O-])c1O",
        "output": "127"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)c1ccc(C(=O)O)s1.Nc1cccc(C(=O)c2ccc3c(c2)NC(=O)C3)c1.O=S(Cl)Cl>>CC(=O)c1ccc(C(=O)Nc2cccc(C(=O)c3ccc4c(c3)NC(=O)C4)c2)s1",
        "output": "822"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=C(CCOCc1ccccc1)N1c2ccccc2CCC1CN1CCN(c2ccccc2OCC(F)(F)F)CC1.O=C[O-].[NH4+].[Pd]>>O=C(CCO)N1c2ccccc2CCC1CN1CCN(c2ccccc2OCC(F)(F)F)CC1",
        "output": "178"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.Cc1ccc(F)c(N)c1.ClCCl.Clc1ccnc(Cl)n1>>Cc1ccc(F)c(Nc2ccnc(Cl)n2)c1",
        "output": "161"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.CCc1cc(Cl)ccc1OC.CO.ClCCl>>CCc1cc(Cl)ccc1O",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(N=[N+]=[N-])C(=O)O.O=S(Cl)Cl>>COC(N=[N+]=[N-])C(=O)Cl",
        "output": "53"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.O.O=C([O-])O.O=S(=O)(c1ccc(Cl)cc1)N1C(CO)CCCC1c1ccccc1.[Na+]>>O=CC1CCCC(c2ccccc2)N1S(=O)(=O)c1ccc(Cl)cc1",
        "output": "610"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)[O-].CO.COC(=O)c1ccc([C@H]2CC(=O)c3ccc(O)cc3O2)cc1.CON.Cl.[Na+]>>CON=C1C[C@H](c2ccc(C(=O)OC)cc2)Oc2cc(O)ccc21",
        "output": "212"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Cl.C[C@H](CO)C(=O)O.c1ccncc1>>CC(=O)OC[C@@H](C)C(=O)O",
        "output": "126"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cl.O.O=C(O)c1ccccc1S.O=C([O-])[O-].O=[N+]([O-])c1ccccc1F.[K+].[K+]>>O=C(O)c1ccccc1Sc1ccccc1[N+](=O)[O-]",
        "output": "675"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)CCCCCCNC(=O)c1ccc(N=Nc2ccccc2)cc1.Cl.NO.[Na+].[OH-]>>O=C(CCCCCCNC(=O)c1ccc(N=Nc2ccccc2)cc1)NO",
        "output": "376"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1ccc2cc(Cn3cc(C(=O)O)cn3)ccc2n1.F[P-](F)(F)(F)(F)F.NCc1c[nH]c2ccc(Cl)cc12>>Cc1ccc2cc(Cn3cc(C(=O)NCc4c[nH]c5ccc(Cl)cc45)cn3)ccc2n1",
        "output": "621"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)COc1cc(F)c(-n2c(N)c(C(=O)c3ccc(F)cc3)ccc2=O)c(F)c1.ClCCl.O=C(O)C(F)(F)F>>Nc1c(C(=O)c2ccc(F)cc2)ccc(=O)n1-c1c(F)cc(OCC(=O)O)cc1F",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)c1ccccc1CCC(=O)O.Cc1ccccc1.O=S(Cl)Cl>>CC(C)c1ccccc1CCC(=O)Cl",
        "output": "53"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(=O)Cl.CCOC(C)=O.O=C1C(=Cc2ccc3c(c2)OCO3)Oc2cc(O)ccc21.c1ccncc1>>CCC(=O)Oc1ccc2c(c1)OC(=Cc1ccc3c(c1)OCO3)C2=O",
        "output": "111"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)NS(=O)(=O)c1ccccc1C(=O)OCCI.O=C(O)C(F)(F)F>>NS(=O)(=O)c1ccccc1C(=O)OCCI",
        "output": "680"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CCN(C(C)C)C(C)C.CS(=O)(=O)c1ccc(F)c(Br)c1.CS(C)=O.[Cl-].[NH4+]>>CC(C)(C)OC(=O)N1CCC(Nc2ccc(S(C)(=O)=O)cc2Br)CC1",
        "output": "572"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[C@H](N)CO.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1nn(-c2cnccn2)c2c1C[C@@H]1C[C@H]21>>CC(C)(C)[C@@H](CO)NC(=O)c1nn(-c2cnccn2)c2c1C[C@@H]1C[C@H]21",
        "output": "816"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.COc1cc2c(Oc3ccc(Br)cc3F)ccnc2cc1OCCCN1CCOCC1.Nc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>COc1cc2c(Oc3ccc(Nc4ccccc4)cc3F)ccnc2cc1OCCCN1CCOCC1",
        "output": "405"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.ClCCl.Nc1ccc(C(=O)c2ccc(F)cc2)cc1C(=O)c1cccc(Cl)c1.O=C(Cl)C(Cl)(Cl)Cl>>O=C(c1ccc(F)cc1)c1ccc(NC(=O)C(Cl)(Cl)Cl)c(C(=O)c2cccc(Cl)c2)c1",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(NCCCn1ccnc1)c1ccc(CCN)cc1.ClCCl.O=S(=O)(Cl)c1ccccc1>>CC(C)(NCCCn1ccnc1)c1ccc(CCNS(=O)(=O)c2ccccc2)cc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.Cl.NC(=O)CC1(NC(=O)c2ccc(C3CC3)c(Cc3ccc(F)cc3)n2)CCNCC1.c1ccncc1>>CC(=O)N1CCC(CC(N)=O)(NC(=O)c2ccc(C3CC3)c(Cc3ccc(F)cc3)n2)CC1",
        "output": "369"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COC(=O)Nc1ccc(F)c([N+](=O)[O-])c1.NCC1CCOCC1>>COC(=O)Nc1ccc(NCC2CCOCC2)c([N+](=O)[O-])c1",
        "output": "572"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@H]1c1ccccc1C(C)C.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>CC(C)c1ccccc1[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CC(=O)O.CN1CCCN(C)C1=O.CO.O=Cc1cc2c(Nc3cccc(Cl)c3)ncnc2[nH]1.[Ni]>>Clc1cccc(Nc2ncnc3[nH]c(CN4CCOCC4)cc23)c1",
        "output": "829"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)O[C@H]1COC[C@H]1N=[N+]=[N-].CCO.[Pd]>>CC(C)(C)[Si](C)(C)O[C@H]1COC[C@H]1N",
        "output": "89"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.ClCCl.Cl[Pd]Cl.FC(F)c1cncc(Br)c1.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2cncc(C(F)F)c2)OC1(C)C",
        "output": "943"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN.CCN(CC)CC.CCOC(=O)Cl.O.O=C(O)CCc1cnoc1-c1ccccc1>>CCNC(=O)CCc1cnoc1-c1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.C[Si](C)(C)C#Cc1ccc(Cl)nc1.[F-]>>C#Cc1ccc(Cl)nc1",
        "output": "337"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1ncc2c(c1O)c(Br)c(Br)n2Cc1cccc(OC)c1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>CCOC(=O)c1nc(Br)c2c(c1O)c(Br)c(Br)n2Cc1cccc(OC)c1",
        "output": "665"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CCO.CC[C@@H](C(N)=O)N1CC(C(=O)OC)CC1=O.ClCCl.[BH4-].[Cl-].[NH4+].[Na+]>>CC[C@@H](C(N)=O)N1CC(CO)CC1=O",
        "output": "343"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cc1nc(-c2cn(CC(F)(F)c3ccccc3)nn2)sc1C(=O)O.Cl.NCc1cccnc1.On1nnc2ccccc21>>Cc1nc(-c2cn(CC(F)(F)c3ccccc3)nn2)sc1C(=O)NCc1cccnc1",
        "output": "534"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCCOCCOc1ccc(-c2cc3c4c(c2)OCCN4CCCC(C(=O)OCC)=C3)cc1.CCO.Cl.[Na+].[OH-]>>CCCCOCCOc1ccc(-c2cc3c4c(c2)OCCN4CCCC(C(=O)O)=C3)cc1",
        "output": "122"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1CCc2ccc(Br)cc21>>CC(C)(C)OC(=O)NC1CCc2ccc(Br)cc21",
        "output": "686"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.COc1ccc(C(=O)Cl)c(OC)c1.ClCCl.O=C1NCc2ccccc2N1C1CCNCC1>>COc1ccc(C(=O)N2CCC(N3C(=O)NCc4ccccc43)CC2)c(OC)c1",
        "output": "201"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.FC(F)(F)c1ccc(CCBr)cc1.O.OC(c1ccccc1)(c1ccccc1)C1CCNCC1>>OC(c1ccccc1)(c1ccccc1)C1CCN(CCc2ccc(C(F)(F)F)cc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.COC(=O)c1ccc(NC(=O)c2cnn3cccnc23)c(OC)c1.CS(C)=O.N.[NH4+].[OH-]>>COc1cc(C(N)=O)ccc1NC(=O)c1cnn2cccnc12",
        "output": "67"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(CO)NS(=O)(=O)c1cccc(N)c1.Cc1cc(-c2cc(C(F)(F)F)n3ncc(C(=O)O)c3n2)ccc1C(F)(F)F>>Cc1cc(-c2cc(C(F)(F)F)n3ncc(C(=O)Nc4cccc(S(=O)(=O)NC(C)(C)CO)c4)c3n2)ccc1C(F)(F)F",
        "output": "969"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCOC(=O)CCCN.Cl.ClCCl.O=[N+]([O-])c1cnc2ccccc2c1Cl>>CCOC(=O)CCCNc1c([N+](=O)[O-])cnc2ccccc12",
        "output": "78"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)C1CC1(C)c1ccc(C(F)(F)F)cc1.CO.[Na+].[OH-]>>CC1(c2ccc(C(F)(F)F)cc2)CC1C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC1=NN(c2ccc(C)c(C)c2)C(=O)C1=NNc1cccc(-c2cccc(C(=O)O)c2)c1O.CCCCCCC.CN(C)C=O.O=S(Cl)Cl>>CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\\Nc1cccc(-c2cccc(C(=O)Cl)c2)c1O",
        "output": "3"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.NOCC1CC1.O=C(O)c1ccc2[nH]ncc2c1Nc1ccc(I)cc1F.On1nnc2ccccc21>>O=C(NOCC1CC1)c1ccc2[nH]ncc2c1Nc1ccc(I)cc1F",
        "output": "741"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(O)CN.O=S(CCCCl)CCC(F)(F)F>>CC(C)(O)CNCCCS(=O)CCC(F)(F)F",
        "output": "279"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CN(C)C=O.NC(=O)c1c(F)ccc(O[C@H](COCc2ccccc2)C(=O)Nc2cc(Cl)cnc2Cl)c1F.O.O=C(Cl)C(=O)Cl>>N#Cc1c(F)ccc(O[C@H](COCc2ccccc2)C(=O)Nc2cc(Cl)cnc2Cl)c1F",
        "output": "374"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1c(-c2ccc(N)cc2)noc1C.CCOC(=O)c1c(-c2ccc(N=[N+]=[N-])cc2)noc1C>>Cc1onc(-c2ccc(N=[N+]=[N-])cc2)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1ccc(N(C)C(=O)c2ccccc2C)cc1.CO.[Na+].[OH-]>>Cc1ccccc1C(=O)N(C)c1ccc(C(=O)O)cc1",
        "output": "5"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1C=COc2ccc(C=O)cc21.O=C1CSC(=O)N1>>CC(C)(C)OC(=O)N1C=COc2ccc(C=C3SC(=O)NC3=O)cc21",
        "output": "761"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Oc1ccc2c(c1)C(O)CC(c1ccc(Cl)cc1Cl)O2.Oc1ccc2c(c1)CCC(c1cccc(F)c1)O2>>Oc1ccc2c(c1)CCC(c1ccc(Cl)cc1Cl)O2",
        "output": "447"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(N2CCCC2=O)cc1N1CCCS1(=O)=O.[Na+].[OH-]>>O=C(O)c1ccc(N2CCCC2=O)cc1N1CCCS1(=O)=O",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2c[nH]c3ccccc23)CC1.CN(C)C=O.CS(=O)(=O)c1ccc(CBr)cc1.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCC(c2cn(Cc3ccc(S(C)(=O)=O)cc3)c3ccccc23)CC1",
        "output": "528"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cnc(-c2nnc(N3CCC(Oc4cc(F)ccc4Br)CC3)s2)nc1.Cl.[Na+].[OH-]>>O=C(O)c1cnc(-c2nnc(N3CCC(Oc4cc(F)ccc4Br)CC3)s2)nc1",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COc1ccc(C(=O)CCC(=O)Nc2cc(-c3ccccc3)c(Cc3ccccc3)s2)cc1CCCOC(C)=O.[Na+].[OH-]>>COc1ccc(C(=O)CCC(=O)Nc2cc(-c3ccccc3)c(Cc3ccccc3)s2)cc1CCCO",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1cc(COC)n(C)n1.CO.[Li+].[OH-]>>COCc1cc(C(=O)O)nn1C",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCBr.CS(C)=O.N#Cc1ccc(Br)c2[nH]ccc12.O.[K+].[OH-]>>CCn1ccc2c(C#N)ccc(Br)c21",
        "output": "470"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)CCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(O)CCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1",
        "output": "91"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C[C@H]2NC(=O)n3c2nc2ccccc23)cc1.N[C@@H]1CC[C@H](O)CC1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F>>COc1ccc(C[C@@H](NC(=O)N[C@@H]2CC[C@H](O)CC2)c2nc3ccccc3[nH]2)cc1",
        "output": "999"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.COc1ccc(CC(O)C(C)C)c(NC(=O)OC(C)(C)C)c1.ClCCl>>COc1ccc(CC(=O)C(C)C)c(NC(=O)OC(C)(C)C)c1",
        "output": "87"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)C(C=C(c2ccccc2)C(F)(F)F)C1C(=O)O.ClC(Cl)(Cl)Cl.O=S(Cl)Cl>>CC1(C)C(C=C(c2ccccc2)C(F)(F)F)C1C(=O)Cl",
        "output": "53"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)NC(Cc1ccc(Oc2ccc(C(=O)O)cc2)cc1)C(=O)OCc1ccccc1.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CN1CCOCC1.Cl.F[P-](F)(F)(F)(F)F.NO>>CC(C)(C)OC(=O)NC(Cc1ccc(Oc2ccc(C(=O)NO)cc2)cc1)C(=O)OCc1ccccc1",
        "output": "741"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)Oc1cccnc1Cl.CO.[Na]>>COc1ncccc1OC(C)C",
        "output": "433"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#Cc1ccc(C2=CCC(C)CC2)cn1.CC1(O)CCN(C/C=C/c2ccc(I)cc2)CC1>>CC1CC=C(c2ccc(C#Cc3ccc(/C=C/CN4CCC(C)(O)CC4)cc3)nc2)CC1",
        "output": "664"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COCCOC(=O)Cl.Cl.ClCCl.N[C@@H]1CCN(c2ccc(N3C[C@H](Cn4ccnn4)OC3=O)cc2F)C1.O=C([O-])O.[Na+]>>COCCOC(=O)N[C@@H]1CCN(c2ccc(N3C[C@H](Cn4ccnn4)OC3=O)cc2F)C1",
        "output": "94"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.O.O=C1CCC(=O)N1Br.O=c1ccc(-c2ncccn2)c[nH]1>>O=c1[nH]cc(-c2ncccn2)cc1Br",
        "output": "518"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=[N+]=[N-].CC(C)(C)OC(=O)N[C@@H](CO)C(=O)O.CCOCC>>COC(=O)[C@H](CO)NC(=O)OC(C)(C)C",
        "output": "60"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=[N+]([O-])c1ccc(N2CCCCC2)cc1-c1cc(C(O)c2cccc(C(F)(F)F)c2)ccn1.[Pd]>>Nc1ccc(N2CCCCC2)cc1-c1cc(C(O)c2cccc(C(F)(F)F)c2)ccn1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ccccc21.CN(C)C=O.CN1C(=O)C(F)(F)CN(C2CCCC2)c2nc(Nc3ccc(C(=O)O)cc3C(F)(F)F)ncc21.F[P-](F)(F)(F)(F)F.On1nnc2ccccc21>>CN1C(=O)C(F)(F)CN(C2CCCC2)c2nc(Nc3ccc(C(=O)NC4CCN(C(=O)OC(C)(C)C)CC4)cc3C(F)(F)F)ncc21",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)CCSC(CCCc1ccccc1)c1ccc(OCCCOc2ccc(C(=O)C(F)(F)F)cc2)cc1.[Li+].[OH-]>>O=C(O)CCSC(CCCc1ccccc1)c1ccc(OCCCOc2ccc(C(=O)C(F)(F)F)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCc1cn(Cc2ccc(OCn3nnc4ccccc43)cc2)nc1OCC.Cl.[Na+].[OH-]>>CCOc1nn(Cc2ccc(OCn3nnc4ccccc43)cc2)cc1CCC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CN(C)C=O.O.O=C([O-])[O-].O=Cc1ccc(F)cc1.[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCN(c2ccc(C=O)cc2)CC1",
        "output": "26"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CN1CCC(CO)C1.N#Cc1cccc(F)c1.[H-].[Na+]>>CN1CCC(COc2cccc(C#N)c2)C1",
        "output": "485"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.Cl.ClCCN1CCOCC1.O=C([O-])[O-].O=[N+]([O-])c1ccc(O)cc1.[K+].[K+]>>O=[N+]([O-])c1ccc(OCCN2CCOCC2)cc1",
        "output": "74"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1.O.[Li+].[OH-]>>CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)C1=Cc2cc(Cl)ccc2NC1C(F)(F)F.CO.O.[Na+].[OH-]>>O=C(O)C1=Cc2cc(Cl)ccc2NC1C(F)(F)F",
        "output": "122"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCCBr.CCCCCCCCOc1ccc(C2CCc3c(cc(F)c(F)c3O)C2(F)F)cc1.CCOCC>>CCCCCCCCOc1ccc(C2CCc3c(cc(F)c(F)c3OCCCCCCCC)C2(F)F)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(c2cc3cc(C(=O)O)cc([N+](=O)[O-])c3[nH]2)CC1.CC(C)COC(=O)Cl.CN1CCOCC1.CO.Cl.[BH4-].[Na+]>>CC(C)(C)OC(=O)N1CCC(c2cc3cc(CO)cc([N+](=O)[O-])c3[nH]2)CC1",
        "output": "72"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)c1ccccc1S(=O)(=O)N=C=O.COc1nc(N)nc(OC)n1.ClCCl>>COC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc1nc(OC)nc(OC)n1",
        "output": "566"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(N1CCCC(COc2cccnc2)C1)C1(c2ccc(Cl)cc2)CCC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Clc1ccc(C2(CN3CCCC(COc4cccnc4)C3)CCC2)cc1",
        "output": "112"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=O.Fc1ccc(C2CCNCC2)c(F)c1.O.O=CO>>CN1CCC(c2ccc(F)cc2F)CC1",
        "output": "217"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.[Pd].c1ccc(COc2ccc(Oc3ccnc4[nH]ccc34)cc2)cc1>>Oc1ccc(Oc2ccnc3[nH]ccc23)cc1",
        "output": "23"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.CC(O)(CCO)c1ccc(-c2ccc(F)cc2F)cc1.ClC(Cl)Cl.O.c1ccncc1>>CC(=O)OCCC(C)(O)c1ccc(-c2ccc(F)cc2F)cc1",
        "output": "254"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COCCO[Al+]OCCOC.Cc1ccccc1.O=C([O-])C(O)C(O)C(=O)[O-].O=C1COc2ccccc2N1.[H-].[H-].[K+].[Na+].[Na+]>>c1ccc2c(c1)NCCO2",
        "output": "363"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCCC[C@H](NS(=O)(=O)c1ccc(Br)cc1)C(=O)O.CCOC(=O)Cc1ccc(N)cc1.ClCCl>>CCCC[C@H](NS(=O)(=O)c1ccc(Br)cc1)C(=O)Nc1ccc(CC(=O)OCC)cc1",
        "output": "365"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCO.CCOC(=O)c1cc(C#N)c(Cl)nc1C.CCOC(C)=O.O=C(NS(=O)(=O)Cc1ccccc1)C1CCNCC1.O=S(=O)([O-])O.[K+]>>CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccccc3)CC2)nc1C",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CN(C)C(=O)c1ccc(Nc2cc(Cc3ccc(F)cc3)cnc2C(=O)O)cc1.CO.CO.C[Si](C)(C)C=[N+]=[N-].ClCCl>>COC(=O)c1ncc(Cc2ccc(F)cc2)cc1Nc1ccc(C(=O)N(C)C)cc1",
        "output": "195"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C1COCCN1c1ccc(N2C[C@H](CO)OC2=O)cc1>>CS(=O)(=O)OC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(C(C)C)C(C)C.Nc1ccc([N+](=O)[O-])c(CCO)c1F>>CC(=O)OCCc1c([N+](=O)[O-])ccc(N)c1F",
        "output": "126"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.COc1c(C)cc(OCc2ccccc2)c2ccccc12.[H][H].[Pd]>>COc1c(C)cc(O)c2ccccc12",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.Nc1ccc(-c2nc3ccc(O)cc3s2)cn1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1ccc2nc(-c3ccc(N)nc3)sc2c1",
        "output": "746"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CCC(=O)c1ccncc1.CO.NC1CC1.[BH3-]C#N.[Na+]>>CCC(NC1CC1)c1ccncc1",
        "output": "693"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1ccc(N2CCNCC2)cc1.CCOC(=O)Nc1nc2ccc(OC)cc2nc1OC>>COc1ccc2nc(NC(=O)N3CCN(c4ccc(C(C)=O)cc4)CC3)c(OC)nc2c1",
        "output": "613"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCc1ccc(Br)cn1>>CC(C)(C)OC(=O)NCCc1ccc(Br)cn1",
        "output": "631"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCCNc1nc(Nc2cccc(F)c2)ncc1-c1cc(CCO[Si](C)(C)C(C)(C)C)no1.CCOC(C)=O.O=C([O-])O.[F-].[Na+]>>CCCNc1nc(Nc2cccc(F)c2)ncc1-c1cc(CCO)no1",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.CCOC(=O)COc1ccc2c(c1)c(CC(N)=O)c(C)n2Cc1ccccc1.Cl.[Na+].[OH-]>>Cc1c(CC(N)=O)c2cc(OCC(=O)O)ccc2n1Cc1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)OC(=O)/N=N/C(=O)OC(C)C.CCCCCC.CCOC(C)=O.COC(=O)CCc1cc(Cl)c(O)c(Br)c1.OCC1CCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)CCc1cc(Cl)c(OCC2CCCC2)c(Br)c1",
        "output": "478"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C#N)c1ccccc1CBr.CN(C)C=O.Cc1ccccc1O.[H-].[Na+]>>Cc1ccccc1OCc1ccccc1N(C)C#N",
        "output": "127"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)C(=O)c1ccc(-c2ncc(Cl)c(Nc3cc(C4CC4)[nH]n3)n2)s1.[Na+].[OH-]>>O=C(O)C(=O)c1ccc(-c2ncc(Cl)c(Nc3cc(C4CC4)[nH]n3)n2)s1",
        "output": "472"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)CCC1(c2ccc(F)cc2)CCCCC1>>O=C(Cl)CCC1(c2ccc(F)cc2)CCCCC1",
        "output": "56"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Nc1cc(N)cc(-c2ccc(F)cc2F)c1.CN(C)C=O.O=[N+]([O-])c1cc(Br)ccc1F.[F-].[K+]>>CC(=O)Nc1cc(Nc2ccc(Br)cc2[N+](=O)[O-])cc(-c2ccc(F)cc2F)c1",
        "output": "609"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)OC[C@H](C(F)(F)F)N(C(=O)C1CCOCC1)C2.NO.[Na+].[OH-]>>O=C(NO)c1ccc2c(c1)OC[C@H](C(F)(F)F)N(C(=O)C1CCOCC1)C2",
        "output": "988"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCBr.CCOCC.CN(C)C=O.Cc1c(Br)cnn1CC1(O)CCCC(C)(C)C1.[H-].[Na+]>>C=CCOC1(Cn2ncc(Br)c2C)CCCC(C)(C)C1",
        "output": "120"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1onc(-c2ccccc2)c1C(=O)OC.O.[Li+].[OH-]>>COC(=O)c1c(-c2ccccc2)noc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)NCCc1ccccn1.CC(=O)O.O=S([O-])[O-].OO.[Na+].[Na+]>>CC(=O)NCCc1cccc[n+]1[O-]",
        "output": "396"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CN(C)CCCl.C[C@@]1(C(F)(F)F)Cn2c(nc(N3CC4CCC(C3)O4)cc2=O)N1CCc1ccc(O)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>CN(C)CCOc1ccc(CCN2c3nc(N4CC5CCC(C4)O5)cc(=O)n3C[C@@]2(C)C(F)(F)F)cc1",
        "output": "74"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CNCCN1.CCN(C(C)C)C(C)C.OCc1cccnc1F>>OCc1cccnc1N1CCNCC1",
        "output": "756"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)C=C(C#N)C(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.Nc1ncnc2c1n(-c1ccc(Oc3ccccc3)cc1)c(=O)n2C1CCNC1>>CC(C)(C)C=C(C#N)C(=O)N1CCC(n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1",
        "output": "517"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(Cl)Cl.Cc1ccc(F)cc1O.ClCCl.[Cl-].[Cl-].[Cl-].[Cl-].[Ti+4]>>Cc1cc(C=O)c(F)cc1O",
        "output": "591"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN1CCN(c2ccc([N+](=O)[O-])cc2)CC1.CO.[C].[Pd]>>CN1CCN(c2ccc(N)cc2)CC1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(C(=O)Nc3cccc(Cl)c3)cn2)CC1.CCO.Cl>>O=C(Nc1cccc(Cl)c1)c1ccc(N2CCNCC2)nc1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cc(C2CC2)ncc1-c1cccc(C(=O)CC(=O)Nc2cc(C(F)(F)F)ccc2NC(=O)OC(C)(C)C)c1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(C2CC2)ncc1-c1cccc(C2=Nc3ccc(C(F)(F)F)cc3NC(=O)C2)c1",
        "output": "930"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.CNC.COc1ccc(CC(=O)N2CCC(c3ccc(NC(=O)Oc4ccc([N+](=O)[O-])cc4)cc3)=N2)cc1OC.Cl.O>>COc1ccc(CC(=O)N2CCC(c3ccc(NC(=O)N(C)C)cc3)=N2)cc1OC",
        "output": "770"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(=O)CC1.CC(C)(C)[O-].C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-].[Cl-].[K+].[NH4+]>>C=C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "601"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "B.C1CCOC1.C1CCOC1.CSC.O=C(O)c1cnc(Cl)c(Cl)c1>>OCc1cnc(Cl)c(Cl)c1",
        "output": "293"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.COC(=O)[C@H](C)O.Cc1ccccc1.[H-].[Na+]>>C[C@H](O)C(=O)N1CCOCC1",
        "output": "227"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.Nc1ccc(Cl)c(O)c1.O.O=C1OC(=O)C2=C1CCCC2>>O=C1C2=C(CCCC2)C(=O)N1c1ccc(Cl)c(O)c1",
        "output": "410"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CN(C)C=O.COc1ccccc1N1CCNCC1.O=C([O-])[O-].O=C1c2ccccc2C(=O)N1CCBr.[K+].[K+]>>COc1ccccc1N1CCN(CCN2C(=O)c3ccccc3C2=O)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1cncc(Oc2ccccc2)c1.CC(C)(C)[O-].Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[K+].[Pd].[Pd].c1ccc(CN2CCCC23CCNC3)cc1.c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>c1ccc(CN2CCCC23CCN(c2cncc(Oc4ccccc4)c2)C3)cc1",
        "output": "597"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCc1nc(C)[nH]c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CN(C)C=O.Fc1cccc(CBr)c1F.O=C([O-])[O-].[K+].[K+]>>CCCCc1nc(C)n(Cc2cccc(F)c2F)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "389"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CN(C)C=O.O.O=c1ccn2c(Cl)cccc2c1-c1c(Cl)cccc1Cl.OCC1CC1.[H-].[Na+]>>O=c1ccn2c(OCC3CC3)cccc2c1-c1c(Cl)cccc1Cl",
        "output": "433"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)C(N)c1c[nH]c2c(CC)cccc12.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCc1cccc2c(C(N)CO)c[nH]c12",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)C1CN(Cc2ccc(-c3ccc(S(=O)(=O)N(C)c4cccc(OC)c4)cc3)cc2)C1.O.[Li+].[OH-]>>COc1cccc(N(C)S(=O)(=O)c2ccc(-c3ccc(CN4CC(C(=O)O)C4)cc3)cc2)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.Nc1ccc(C2CC2)cc1[N+](=O)[O-].[Cl-].[NH4+].[Zn]>>Nc1ccc(C2CC2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(C)=O.Cc1ccc(Nc2nccc(-c3cccnc3)n2)cc1[N+](=O)[O-]>>Cc1ccc(Nc2nccc(-c3cccnc3)n2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1ccc2ncccc2c1.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)Nc1ccc2ncccc2c1",
        "output": "473"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)OB(c2cc(O)cc(Cl)c2)OC1(C)C.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC1(C)OB(c2cc(Cl)cc(OS(C)(=O)=O)c2)OC1(C)C",
        "output": "149"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.Fc1ccc(-c2nc(C3CCCNC3)no2)cc1.O=C(Cl)c1ccc(F)c(F)c1>>O=C(c1ccc(F)c(F)c1)N1CCCC(c2noc(-c3ccc(F)cc3)n2)C1",
        "output": "201"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)C(=O)Cl.CCN(CC)CC.ClCCl.NCCC[C@H]1COCc2nc3c(N)nc4ccccc4c3n21>>CC(C)C(=O)NCCC[C@H]1COCc2nc3c(N)nc4ccccc4c3n21",
        "output": "45"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCCCCCC(=O)OC(OCCCCCCCC)C(O)CO>>CCCCCCCCCCCCCCCC(=O)O",
        "output": "151"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCCCCCCc1noc(-c2cccc(C=O)c2)n1.COc1ccccc1CN>>CCCCCCCCCCCc1noc(-c2cccc(CNCc3ccccc3OC)c2)n1",
        "output": "683"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN1CCC[C@H]1C(=O)O.CNC1CCN(C(=O)OC(C)(C)C)CC1.Cl.On1nnc2ccccc21>>CN(C(=O)[C@@H]1CCCN1C)C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "685"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CS(C)=O.OCc1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Br)cc1Cl>>O=Cc1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Br)cc1Cl",
        "output": "520"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(C)(C)c1cccc2c1OCC2(C)C.O=[N+]([O-])O>>CC(C)(C)c1cc([N+](=O)[O-])cc2c1OCC2(C)C",
        "output": "21"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCS.N#Cc1ccc(F)cc1Cl>>CCSc1ccc(C#N)c(Cl)c1",
        "output": "503"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(C(=O)O)cc1Cl.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>O=C(O)c1ccc(CBr)c(Cl)c1",
        "output": "29"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.COC(=O)C1CCN(c2nc(Nc3ccc(OC)c(OC)c3)c3ncsc3n2)CC1.O.[Na+].[OH-]>>COc1ccc(Nc2nc(N3CCC(C(=O)O)CC3)nc3scnc23)cc1OC",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc2c(c1)c(CCON)c(C)n2C(=O)c1ccc(Cl)cc1.O=CC(O)CO>>COc1ccc2c(c1)c(CCON=CC(O)CO)c(C)n2C(=O)c1ccc(Cl)cc1",
        "output": "118"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.FC(F)(F)c1ccc(OCc2ccccc2)cc1.[H][H].[Pd]>>Oc1ccc(C(F)(F)F)cc1",
        "output": "23"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.C1CCOC1.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(C(C)C)C(C)C.O=C(O)C1CC(O)(c2ccc(CN3CCCC3)c(F)c2)C1>>O=C(C1CC(O)(c2ccc(CN3CCCC3)c(F)c2)C1)N1CCCC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.Nc1cccc(OC(F)(F)F)c1F.O=C1CCC(=O)N1Br>>Nc1ccc(Br)c(OC(F)(F)F)c1F",
        "output": "4"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ncc(COCc2ccccc2)c(C=O)c1O.N#Cc1ccc(-c2ccc(N)cc2)cc1>>Cc1ncc(COCc2ccccc2)c(CNc2ccc(-c3ccc(C#N)cc3)cc2)c1O",
        "output": "359"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCC1CCC(=O)CC1.Cn1nc(NCC(=O)NC2CNC2)c2cc(C(F)(F)F)ccc21.O=C(O)C(F)(F)F>>CCOCC1CCC(N2CC(NC(=O)CNc3nn(C)c4ccc(C(F)(F)F)cc34)C2)CC1",
        "output": "187"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1csc(-c2ccc3c(=O)n(CC(C)C)c(CNC(=O)OC(C)(C)C)c(-c4ccccc4)c3c2)n1.Cl.O.[Na+].[OH-]>>CC(C)Cn1c(CNC(=O)OC(C)(C)C)c(-c2ccccc2)c2cc(-c3nc(C(=O)O)cs3)ccc2c1=O",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(C(=O)O)c1ccc(Br)cc1.CCO>>CCOC(=O)C(CC)c1ccc(Br)cc1",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCC(O)c1ccc2c(C(=O)OC)cccc2c1.O=C(O)c1cccc2ccccc12>>CCCC(O)c1ccc2c(C(=O)O)cccc2c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CCCNC(=N)NC(=O)OCc1ccccc1)C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.NCCNC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)N[C@@H](CCCNC(=N)NC(=O)OCc1ccccc1)C(=O)NCCNC(=O)OCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCCC(C)C[C@@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)O.C=C[C@@H]1C[C@]1(N)C(=O)NS(=O)(=O)C1CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.F[P-](F)(F)(F)(F)F>>C=CCCC(C)C[C@@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@]1(C(=O)NS(=O)(=O)C2CC2)C[C@H]1C=C",
        "output": "131"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cccc(-c2nc(OCCCCl)ns2)c1.ClCCl.O.O=C([O-])[O-].[Na+].[Na+]>>Oc1cccc(-c2nc(OCCCCl)ns2)c1",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Br.CC(=O)O.COc1c(F)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12.O>>O=C(O)c1cn(C2CC2)c2c(O)c(F)c(F)cc2c1=O",
        "output": "424"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cc(C)on1.Cl.O.[Cl-].[Na+].[Na+].[OH-]>>Cc1cc(C(=O)O)no1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CNCCN1.CN(C(=O)c1cc2c(s1)-c1ccccc1OCC2)c1ccc(C(=O)O)cc1Cl>>CN(C(=O)c1cc2c(s1)-c1ccccc1OCC2)c1ccc(C(=O)N2CCNCC2)cc1Cl",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)c(Br)s2)cc1O.OB(O)c1ccccc1O>>COC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)c(-c3ccccc3O)s2)cc1O",
        "output": "864"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC(=O)c1c(C)cc(Oc2cc(C)cc(C)c2)cc1C.CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.[Br-].[Br-].[Br-]>>Cc1cc(C)cc(Oc2cc(C)c(C(=O)CBr)c(C)c2)c1",
        "output": "360"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(CC)CC.CCN=C=NCCCN(C)C.Cc1ncc2n1C(=O)N(C1CCNCC1)C2.Cl.Cl.O=C(O)CCS(=O)(=O)C1=Cc2ccc(Cl)cc2OC1.On1nnc2ccccc21>>Cc1ncc2n1C(=O)N(C1CCN(C(=O)CCS(=O)(=O)C3=Cc4ccc(Cl)cc4OC3)CC1)C2",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(C2CCN(c3cnccn3)CC2)CC1.CN(C)C=O.O.O=C1CCC(=O)N1Br.[Cl-].[Na+]>>CC(C)(C)OC(=O)N1CCC(C2CCN(c3cnc(Br)cn3)CC2)CC1",
        "output": "665"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)c1cc(O)ncn1.CCN(CC)CC.ClCCl.O=P(Cl)(Cl)Cl>>CC(C)(C)c1cc(Cl)ncn1",
        "output": "25"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCCC=O.Nc1ccc([C@@H]2CNCCO2)cn1.O=C([O-])O.[Na+].[Na+]>>CCCCCN1CCO[C@H](c2ccc(N)nc2)C1",
        "output": "484"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "NCCc1ccc(CN2CCCC2)cc1.O=C(O)c1ccc(-c2ccccc2)cc1[N+](=O)[O-]>>O=C(NCCc1ccc(CN2CCCC2)cc1)c1ccc(-c2ccccc2)cc1[N+](=O)[O-]",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(Cl)c(Br)c1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCOCC2)c(Br)c1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)COc1cccc(CBr)c1.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].O[C@H]1CN[C@@H](c2nc(-c3ccccc3)c(-c3ccccc3)o2)C1.[K+].[K+]>>CCOC(=O)COc1cccc(CN2C[C@H](O)C[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cc1oc(-c2ccccc2)nc1COc1ccc(CCl)cc1.N#CCc1c(O)ccc2ccccc12.O.[H-].[Na+]>>Cc1oc(-c2ccccc2)nc1COc1ccc(COc2ccc3ccccc3c2CC#N)cc1",
        "output": "49"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CNOC.Cl.Cl.Nc1nc2ccc(C(=O)O)cn2c1-c1ccccc1>>CON(C)C(=O)c1ccc2nc(N)c(-c3ccccc3)n2c1",
        "output": "879"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)c1ccc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4F)c3s2)cc1.Cn1cnc(-c2cc3nccc(Oc4ccc(N)cc4F)c3s2)c1.O=C(Cc1ccccc1F)N=C=S>>Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5F)cc4F)c3s2)c1",
        "output": "961"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN.COC(=O)c1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C)nc1.COC(=O)c1ccc(OCc2c(-c3ccccc3)noc2C(F)(F)F)nc1>>CCNC(=O)c1ccc(OCc2c(-c3ccccc3)noc2C(F)(F)F)nc1",
        "output": "862"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.O=C([O-])[O-].OCCBr.[K+].[K+].c1cc2[nH]ncc2cc1OC1CCNCC1>>OCCN1CCC(Oc2ccc3[nH]ncc3c2)CC1",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1nnc(-c2ccc(C)c(-c3ccc(C(=O)O)cc3)c2)o1.NC(C1CC1)C1CC1>>Cc1nnc(-c2ccc(C)c(-c3ccc(C(=O)NC(C4CC4)C4CC4)cc3)c2)o1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Br.CC1(CO)COC1.CN(C)C=O.Cc1cc(Cl)nn2c(N)nnc12.O.[H-].[Na+]>>Cc1cc(OCC2(C)COC2)nn2c(N)nnc12",
        "output": "407"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)OC(C)(C)C)[C@H](Cc1cccs1)CN(C)S(C)(=O)=O.ClCCl.O.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CN[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1cccs1)CN(C)S(C)(=O)=O",
        "output": "634"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.Cc1cc(N)cc(C)c1Br.ClCCl>>CC(=O)Nc1cc(C)c(Br)c(C)c1",
        "output": "6"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.ClCCl.Cl[Pd]Cl.O=CC1(c2ccc(Br)cc2)CC1.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc(C3(C=O)CC3)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.C[Si](C)(C)C=[N+]=[N-].ClCCl.O=C(O)c1ccc2nc(Br)sc2c1>>COC(=O)c1ccc2nc(Br)sc2c1",
        "output": "195"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.Cl.Cn1cc(Br)c(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)n1>>Cn1cc(Br)c(C(=O)N2CCNCC2)n1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(=O)CC#N.C[C@@H]1CCNC[C@@H]1N(C)c1ncnc2[nH]ccc12.Cc1ccccc1>>C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12",
        "output": "494"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCOc1ccc(C)c([N+](=O)[O-])c1.CCO>>CCCOc1ccc(C)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)O)cc1Cl.ClCCl.Cn1ccc(N)n1.O.O=C1CCC(=O)N1Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccncc1>>Cn1ccc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)c(Cl)c2)n1",
        "output": "795"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Br.CC(=O)O.COc1ccc2c(c1)C(c1cc(F)cc(F)c1)=C(c1cccnc1)C2=O.[Na+].[OH-]>>O=C1C(c2cccnc2)=C(c2cc(F)cc(F)c2)c2cc(O)ccc21",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.C[C@H](N)C(C)(C)C#N.Cl.ClCCCl.Cn1cc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)cn1.On1nnc2ccccc21>>C[C@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3cnn(C)c3)nc12)C(C)(C)C#N",
        "output": "737"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.NC(=O)CBr.O=C([O-])[O-].OCc1cccc(O)c1.[K+].[K+]>>NC(=O)COc1cccc(CO)c1",
        "output": "778"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=C(O)c1ccc2c(c1)Sc1cc3c(cc1CC2)CCC3.O=S(=O)(O)O>>COC(=O)c1ccc2c(c1)Sc1cc3c(cc1CC2)CCC3",
        "output": "33"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)Cc1c(OCC2CC2)ccc2c(CCC3CCNCC3)noc12.CN(C)c1ccc(C=O)c(F)c1C#N>>CN(C)Cc1c(OCC2CC2)ccc2c(CCC3CCN(Cc4ccc(N(C)C)c(C#N)c4F)CC3)noc12",
        "output": "567"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CC[O-].Cc1ccccc1C.Nc1nc(Cl)c2c(n1)CCC2.[Na+]>>CCOc1nc(N)nc2c1CCC2",
        "output": "461"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(C)=O.Nc1c2c(nc3ccccc13)CCCC2.O=C1c2ccccc2C(=O)N1CCCCCCCCBr.[K+].[OH-]>>O=C1c2ccccc2C(=O)N1CCCCCCCCNc1c2c(nc3ccccc13)CCCC2",
        "output": "273"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC(=O)OCCCNc1c([N+](=O)[O-])cnc2cc(Br)ccc12.[Pt]>>CC(=O)OCCCNc1c(N)cnc2cc(Br)ccc12",
        "output": "269"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc(Br)nc1.FC1(F)CCNCC1.O>>FC1(F)CCN(c2ccc(Br)cn2)CC1",
        "output": "647"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCc1ccc(Br)cc1[N+](=O)[O-].CCO.Cl.Cl[Sn]Cl.O.O>>CCCc1ccc(Br)cc1N",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCCN.COc1cc(F)ccc1-c1nnc(-c2c(-c3ccccc3)noc2C)o1>>COCCNc1ccc(-c2nnc(-c3c(-c4ccccc4)noc3C)o2)c(OC)c1",
        "output": "572"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.CCO.Cl.Nc1ccc(Cc2ccccc2)cc1.O.O=[N+]([O-])O.[Na+].[OH-]>>Nc1ccc(Cc2ccccc2)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CC(C)n1c(=O)cc(Cl)[nH]c1=O.CN1CCCC1=O.N[C@H](c1ccccc1)C(F)(F)F.O>>CC(C)n1c(=O)cc(N[C@H](c2ccccc2)C(F)(F)F)[nH]c1=O",
        "output": "165"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CCSc1cc(-c2cn(C)nc2-c2ccccc2F)ccc1[N+](=O)[O-].Cl[Sn]Cl.O.O>>CCSc1cc(-c2cn(C)nc2-c2ccccc2F)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(C)(C(=O)O)C(F)(F)F.CC(C)=C(Cl)N(C)C.Cc1nnc2c(=O)n(Cc3ccccc3)[nH]c(-c3ccccc3)c1-2.Cl.ClCl.NCc1ccc(Cl)c(C(=O)O)c1Cl.c1ccncc1>>CC(C)(C(=O)NCc1ccc(Cl)c(C(=O)O)c1Cl)C(F)(F)F",
        "output": "599"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1cc(Oc2cc(Cl)ncn2)cc2[nH]c([C@@H]3CCCO3)nc12.Cl.O=C1Nc2ncccc2C2(CCNCC2)O1>>Cc1cc(Oc2cc(N3CCC4(CC3)OC(=O)Nc3ncccc34)ncn2)cc2[nH]c([C@@H]3CCCO3)nc12",
        "output": "162"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cc2c(C)ccc(NS(=O)(=O)c3cccs3)c2[nH]1.CO.O=C(O)CC(O)(CC(=O)O)C(=O)O.[K+].[OH-]>>Cc1ccc(NS(=O)(=O)c2cccs2)c2[nH]c(C(=O)O)cc12",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1ccc(-n2c(CC3CC3)nc3ccccc32)cc1.ClCCl>>Oc1ccc(-n2c(CC3CC3)nc3ccccc32)cc1",
        "output": "402"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)c1ccncc1.ClC(Cl)Cl.O=C(OCc1ccccc1)N1CCC(O)CC1.O=C1CCC(=O)O1>>O=C(O)CCC(=O)OC1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "139"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C=O.CC(C)(C)c1ccccc1O.CCN(CC)CC.CCOCC.C[Mg]Br.Cc1ccccc1.Cl>>CC(C)(C)c1cccc(C=O)c1O",
        "output": "451"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)O.CO.[BH4-].[N-]=[N+]=NC[C@@H](O)c1cccc(Cl)c1.[Na+]>>NC[C@@H](O)c1cccc(Cl)c1",
        "output": "89"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1cc(NC(=O)c2ccc(C(F)(F)F)nc2C)ccc1Cl.O=C([O-])O.[BH4-].[Li+].[Na+]>>Cc1nc(C(F)(F)F)ccc1C(=O)Nc1ccc(Cl)c(CO)c1",
        "output": "444"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCNC(=O)c1cccc(F)c1Nc1nc(Cl)ncc1Cl.COc1cc2c(cc1N)CCN(CC(F)F)CC2>>CCNC(=O)c1cccc(F)c1Nc1nc(Nc2cc3c(cc2OC)CCN(CC(F)F)CC3)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(CCc1ccc2c(c1)C(=O)c1ccccc1CO2)OCc1ccccc1.CCO.O=C[O-].[NH4+].[Pd]>>CC(=O)N(O)CCc1ccc2c(c1)C(=O)c1ccccc1CO2",
        "output": "707"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)O.CC(C)=C(Cl)N(C)C.CCN(C(C)C)C(C)C.Cl.ClCCl.Nc1cccc(-c2ccccc2Cl)c1F.O>>CC(C)(C)OC(=O)N1C[C@H](F)C[C@H]1C(=O)Nc1cccc(-c2ccccc2Cl)c1F",
        "output": "563"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@H](C(=O)O)C1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Nc1ccc2ccccc2n1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N[C@H]1CC[C@@H](C(=O)Nc2ccc3ccccc3n2)C1",
        "output": "368"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)CC(C#N)c1cccc(OC)c1.Cl.[H][H].[OH-].[OH-].[Pd+2]>>CCOC(=O)CC(CN)c1cccc(OC)c1",
        "output": "246"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)Cc1ccc(NC(=O)c2ccc(-c3ccccc3)o2)cc1.O.[Na+].[OH-]>>O=C(O)Cc1ccc(NC(=O)c2ccc(-c3ccccc3)o2)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.COc1ccc(-c2cnc([C@@H]3CCCN3C(=O)OC(C)(C)C)[nH]2)cc1.Cl>>COc1ccc(-c2cnc([C@@H]3CCCN3)[nH]2)cc1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.COC(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1C=Cc1cccc2ccccc12.ClCCl.[K+].[K+].[N-]=[N+](C(=O)[O-])C(=O)[O-]>>COC(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1CCc1cccc2ccccc12",
        "output": "362"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1.c1nc2c([nH]1)CNCC2>>NS(=O)(=O)Cc1cccc(Nc2ncnc(N3CCc4nc[nH]c4C3)n2)c1",
        "output": "214"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)C(C(=O)N1C[C@H]2CC[C@H](N)[C@H]2C1)c1ccccc1.Cl.ClCCl.O=Cc1ccccc1.[BH3-]C#N>>CC(C)C(C(=O)N1C[C@H]2CC[C@H](NCc3ccccc3)[C@H]2C1)c1ccccc1",
        "output": "468"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCCCCC(=O)O.CCNCC.CN(C)C=O.N#Cc1c(O)c2c(-c3cccc(Br)c3)csc2[nH]c1=O.[Cu]I.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1c(O)c2c(-c3cccc(C#CCCCCC(=O)O)c3)csc2[nH]c1=O",
        "output": "659"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CN[C@@H]1CCCC[C@H]1NC.Cc1ccccc1.O=C([O-])[O-].OC(c1ccccc1I)C(F)(F)F.[Cu]I.[K+].[K+].c1ccc(-c2cc[nH]n2)cc1>>OC(c1ccccc1-n1ccc(-c2ccccc2)n1)C(F)(F)F",
        "output": "901"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.C[C@H](N)C1CC1.ClCCCl.O=C([O-])O.O=Cc1ccccc1.[BH3-]C#N.[Na+].[Na+]>>C[C@H](NCc1ccccc1)C1CC1",
        "output": "468"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1ccc(C(=O)O)cc1.O=C(Cl)C1CCC1>>O=C(O)c1ccc(NC(=O)C2CCC2)cc1",
        "output": "9"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.N#Cc1ccc(CCO)cc1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCCc2ccc(C#N)cc2)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(-c2ccccc2)cc1.O=C1CCC(=O)O1.O=[N+]([O-])c1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(-c2ccc(C(=O)CCC(=O)O)cc2)cc1",
        "output": "345"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COc1cc(Cl)ccn1.O=C(c1ccc(Nc2ccnc3cc(C(F)(F)F)ccc23)cc1)N1CCNCC1.OCCO>>COc1cc(N2CCN(C(=O)c3ccc(Nc4ccnc5cc(C(F)(F)F)ccc45)cc3)CC2)ccn1",
        "output": "398"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C=CCOc1ccc2[nH]ccc2c1.O.O=S(=O)(Cl)c1ccccc1.[H-].[Na+]>>C=CCOc1ccc2c(ccn2S(=O)(=O)c2ccccc2)c1",
        "output": "648"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cn2c(n1)C(C)NCC2.O=C(O)c1cc2ncc(Br)cn2n1>>Cc1cn2c(n1)C(C)N(C(=O)c1cc3ncc(Br)cn3n1)CC2",
        "output": "663"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCCC[C@H]1C(OC(=O)Nc1ccc2[nH]ncc2c1)c1cccc(C(=O)Nc2ccc(C(C)(C)C)cc2)c1.Cl>>CC(C)(C)c1ccc(NC(=O)c2cccc(C(OC(=O)Nc3ccc4[nH]ncc4c3)[C@@H]3CCCCN3)c2)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2CO)cc1)C(F)(F)F.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O>>CC(O)(c1ccc(N2CCN(S(=O)(=O)c3cccs3)C[C@@H]2COS(C)(=O)=O)cc1)C(F)(F)F",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COC(=O)CSc1ccc(C)o1.[Na+].[OH-]>>Cc1ccc(SCC(=O)O)o1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1c(-c2ccnn2C)cc(C(=O)NCc2cc(CCC(N)=O)no2)c(=O)n1-c1cccc(C(F)(F)F)c1.ClCCl>>Cc1c(-c2ccnn2C)cc(C(=O)NCc2cc(CCC#N)no2)c(=O)n1-c1cccc(C(F)(F)F)c1",
        "output": "172"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cccc(C)c1NCCN.Clc1ccc(Cl)c(OCC2CO2)c1>>Cc1cccc(C)c1NCCNCC(O)COc1cc(Cl)ccc1Cl",
        "output": "16"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C1(C)CCN(C2=NOC3(C2)CN(Cc2cc(C4CC4)c(C4CC4)c(F)c2OC(C)C)C3)CC1.[Na+].[OH-]>>CC(C)Oc1c(CN2CC3(CC(N4CCC(C)(C(=O)O)CC4)=NO3)C2)cc(C2CC2)c(C2CC2)c1F",
        "output": "281"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.N#Cc1cc(Br)cc(Oc2c(Cl)ccc(CN=[N+]=[N-])c2F)c1.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1cc(Br)cc(Oc2c(Cl)ccc(CN)c2F)c1",
        "output": "562"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Br.CC(=O)O.COc1cc(F)c(-c2cnc(Nc3ccccc3)n(C)c2=O)cc1F.O.[Na+].[OH-]>>Cn1c(Nc2ccccc2)ncc(-c2cc(F)c(O)cc2F)c1=O",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CNc1cc(-c2c[nH]nc2-c2c(F)ccc(N)c2F)ccn1.O=S(=O)(Cl)c1cc(F)ccc1F.c1ccncc1>>CNc1cc(-c2c[nH]nc2-c2c(F)ccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)ccn1",
        "output": "68"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCBr.CC#N.COc1ccc(CO)cc1O.O=C([O-])[O-].[K+].[K+]>>C=CCOc1cc(CO)ccc1OC",
        "output": "77"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Nc1ccccc1.O=C([O-])[O-].O=c1cc(CBr)c2ccccc2[nH]1.[K+].[K+]>>O=c1cc(CNc2ccccc2)c2ccccc2[nH]1",
        "output": "272"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.COc1ccc(CCCBr)cc1.NC(=O)C(c1ccccc1)(c1ccccc1)C1CCCNC1.O=C([O-])[O-].[K+].[K+]>>COc1ccc(CCCN2CCCC(C(C(N)=O)(c3ccccc3)c3ccccc3)C2)cc1",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cn1nc(C(=O)N2CCC(c3ccccc3C(F)(F)F)CC2)c2c1CCSC2.O.O=C([O-])O.O=S([O-])OO.[K+].[Na+]>>Cn1nc(C(=O)N2CCC(c3ccccc3C(F)(F)F)CC2)c2c1CCS(=O)(=O)C2",
        "output": "847"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1.Fc1ccccc1N=C=S.Nc1ccc(-c2cnc(CCNS(=O)(=O)C(F)(F)F)s2)cc1>>O=S(=O)(NCCc1ncc(-c2ccc(NC(=S)Nc3ccccc3F)cc2)s1)C(F)(F)F",
        "output": "474"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1C=C[C@H](CO)C1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O=C([O-])O.[Na+]>>Cc1ccc(S(=O)(=O)OC[C@H]2C=C[C@@H](NC(=O)OC(C)(C)C)C2)cc1",
        "output": "197"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(c1ccccc1-c1ccccc1)C(C)(C)C.CC(C)(C)[O-].Cc1cc(N2CCOCC2)nc(Cl)n1.Cc1ccccc1.NC1CN(C(=O)OCc2ccccc2)CC1F.[Na+].[Pd+2]>>Cc1cc(N2CCOCC2)nc(NC2CN(C(=O)OCc3ccccc3)CC2F)n1",
        "output": "544"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)N(C)C.CN(C)C=O.Cc1ccc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)cc1N.Cn1nccc1C(=O)O.O=S(Cl)Cl>>Cc1ccc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)cc1NC(=O)c1ccnn1C",
        "output": "844"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)CC(=O)Nc1ccc(C(=O)c2ccc(Cl)cc2)cc1.Cl.O.[K+].[OH-]>>O=C(O)CC(=O)Nc1ccc(C(=O)c2ccc(Cl)cc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COc1ccc(N2C(=O)N(c3cccc(C#N)c3)c3nc(Cl)ncc3C2C)c(F)c1.Nc1ccccc1>>COc1ccc(N2C(=O)N(c3cccc(C#N)c3)c3nc(Nc4ccccc4)ncc3C2C)c(F)c1",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Nc1ccc([N+](=O)[O-])cc1C(=O)O>>Nc1ccc([N+](=O)[O-])cc1CO",
        "output": "72"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(N3CCN(C(C)C)C(c4ccc5c(cnn5C)c4)C3)sc2c1-c1ccc(Cl)cc1.Cc1cc2nc(N3CCN(C(=O)OC(C)(C)C)C(c4ccc5c(cnn5C)c4)C3)sc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O>>Cc1cc2nc(N3CCN(C(C)C)C(c4ccc5c(cnn5C)c4)C3)sc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CNOC.Cl.O=C(O)c1cnc(Cl)cc1Cl.O=C(n1ccnc1)n1ccnc1>>CON(C)C(=O)c1cnc(Cl)cc1Cl",
        "output": "879"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)C1(C(N)=O)CCNCC1.O=C([O-])[O-].O=S1(=O)CCCC1.OCCBr.[K+].[K+]>>COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)C1(C(N)=O)CCN(CCO)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.O=[N+]([O-])c1ccc(-c2ccc(O)cc2)cc1.OC1CN2CCC1CC2.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=[N+]([O-])c1ccc(-c2ccc(OC3CN4CCC3CC4)cc2)cc1",
        "output": "550"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(=O)(=O)CCN.O=S(=O)(Nc1cccc(-c2nc(N3CCCC3)sc2-c2ccnc(Cl)n2)c1)c1c(F)cccc1F>>CS(=O)(=O)CCNc1nccc(-c2sc(N3CCCC3)nc2-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2)n1",
        "output": "544"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)C1CC1c1cnc(N)c2c(-c3ccc(NC(=O)c4cc5ccccc5n4C)c(OC)c3)csc12.CO.[Na+].[OH-]>>COc1cc(-c2csc3c(C4CC4C(=O)O)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.Cc1c(CO)cccc1-c1ccc2c(c1)OCCO2.O=Cc1ccc(O)c(Cl)c1O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1c(COc2ccc(C=O)c(O)c2Cl)cccc1-c1ccc2c(c1)OCCO2",
        "output": "347"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[P-](F)(F)(F)(F)F.N#Cc1ccc(F)c(C(=O)O)c1.Nc1cccc(S(N)(=O)=O)c1.O>>N#Cc1ccc(F)c(C(=O)Nc2cccc(S(N)(=O)=O)c2)c1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.Cc1oc(-c2ccccc2)nc1CCl.O.O=C([O-])[O-].Oc1ccc(OCc2ccccc2)cc1.[K+].[K+]>>Cc1oc(-c2ccccc2)nc1COc1ccc(OCc2ccccc2)cc1",
        "output": "760"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CS(C)=O.Cc1noc(NC(=O)OCC(Cl)(Cl)Cl)c1C.O>>Cc1noc(NC(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c1C",
        "output": "980"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)[Si](Cl)(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Cc1c(C)c2c(c(C)c1O)CCC(=O)O2.c1c[nH]cn1>>Cc1c(C)c2c(c(C)c1O[Si](C(C)C)(C(C)C)C(C)C)CCC(=O)O2",
        "output": "746"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cc(Br)ccc2C(=O)O)CC1.CC(C)(C)OC(=O)N1CCNCC1.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[P-](F)(F)(F)(F)F>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(Br)cc2N2CCN(C(=O)OC(C)(C)C)CC2)CC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN.CCN(CC)CC.ClCCl.O=C(Cl)C1CCC1>>CCNC(=O)C1CCC1",
        "output": "45"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CO.Cc1c([N+](=O)[O-])cnc2c1ccn2S(=O)(=O)c1ccccc1.O=C([O-])[O-].[K+].[K+]>>Cc1c([N+](=O)[O-])cnc2[nH]ccc12",
        "output": "831"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1=C(C)C(=O)N(CCOCCO)C1=O.Cc1ccccc1.O=C(O)CCl.O=S(=O)(O)O>>CC1=C(C)C(=O)N(CCOCCOC(=O)CCl)C1=O",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(=O)C1=C(O)CC(c2c(C)cc(C)c(CCl)c2C)CC1=O.[C-]#N.[Na+]>>CCC(=O)C1=C(O)CC(c2c(C)cc(C)c(CC#N)c2C)CC1=O",
        "output": "38"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CC(C)(C)Cc1cc(F)c(OCCCN)c(Br)c1.CN1CCOCC1.Fc1ccccn1>>CCOC(=O)CC(C)(C)Cc1cc(F)c(OCCCNc2ccccn2)c(Br)c1",
        "output": "810"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CNCCCOc1cc(Br)c(N)c(Br)c1.COc1cc2c(cc1OC)C(=O)C(=O)N(CCCCl)CC2>>COc1cc2c(cc1OC)C(=O)C(=O)N(CCCN(C)CCCOc1cc(Br)c(N)c(Br)c1)CC2",
        "output": "138"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.O.O=[N+]([O-])c1ccc(Oc2cccc(C(F)(F)Cc3ccccc3)c2)c(Cl)c1.[Ca+2].[Cl-].[Cl-]>>Nc1ccc(Oc2cccc(C(F)(F)Cc3ccccc3)c2)c(Cl)c1",
        "output": "335"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CC(=O)O.CN(C)CC(C)(C)CN.O=P(O)(O)O.c1ccc(Nc2ccc3ccccc3c2)cc1>>C=CC(=O)NCC(C)(C)CN(C)C",
        "output": "549"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCN(C(C)C)C(C)C.CCOC(=O)C1CCC(O)CC1.CN(C)c1ccncc1.ClCCl>>CCOC(=O)C1CCC(O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CC1",
        "output": "602"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)/C=C/c1ccc(C2c3[nH]c4ccccc4c3CC(C)(C)N2CC(C)(C)F)cc1.O.[Na+].[OH-]>>CC(C)(F)CN1C(c2ccc(/C=C/C(=O)O)cc2)c2[nH]c3ccccc3c2CC1(C)C",
        "output": "58"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)[N-]C(C)C.CCCC1CC=C(c2ccc(Br)cc2F)CC1.CN(C)C=O.[Li+]>>CCCC1CC=C(c2ccc(Br)c(C=O)c2F)CC1",
        "output": "239"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1CC(O)(c2cccc(OCc3ccccc3)c2)CC(C)O1.CI>>COC1(c2cccc(OCc3ccccc3)c2)CC(C)OC(C)C1",
        "output": "140"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.Nc1ccc(F)c(C(F)(F)F)c1.O=C(O)c1ccc(S(=O)(=O)Cl)cc1.[Na+].[OH-].c1ccncc1>>O=C(O)c1ccc(S(=O)(=O)Nc2ccc(F)c(C(F)(F)F)c2)cc1",
        "output": "68"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)O.Cc1c(O[C@@H]2CC[C@@H](N3CCCC3)CC2)ccc2c1cnn2C1CCCCO1.Cl>>Cc1c(O[C@@H]2CC[C@@H](N3CCCC3)CC2)ccc2[nH]ncc12",
        "output": "689"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CO.O=C(OCc1ccccc1)N1C[C@H]2C[C@H]2C[C@H]1CNc1ccc(C(F)(F)F)cn1.[Pd]>>FC(F)(F)c1ccc(NC[C@@H]2C[C@@H]3C[C@@H]3CN2)nc1",
        "output": "428"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(C(=O)C[C@H](c2ccc(CC(=O)O)cc2)c2ccc(Cl)cc2C)ccn1.Cl.NO.O=C([O-])O.[Na+]>>Cc1cc(/C(C[C@H](c2ccc(CC(=O)O)cc2)c2ccc(Cl)cc2C)=N/O)ccn1",
        "output": "212"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.COc1cc(C(C)=O)ccc1OCCCCl.Fc1ccc2c(N3CCNCC3)n[nH]c2c1.O.O=C([O-])[O-].[K+].[K+]>>COc1cc(C(C)=O)ccc1OCCCN1CCN(c2n[nH]c3cc(F)ccc23)CC1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)C1(O)CCc2c(OC)cccc21.O.[Cl-].[Na+].[Na+].[OH-]>>COc1cccc2c1CCC2(O)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)=O.CC(C)O.CN(C)c1ncnc(N(C)C)c1[N+](=O)[O-].O.O=C([O-])[O-].[Fe].[K+].[K+]>>CN(C)c1ncnc(N(C)C)c1N",
        "output": "660"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CS(=O)(=O)c1ccc(CBr)cc1.O=[N+]([O-])c1cc[nH]n1.[H-].[Na+]>>CS(=O)(=O)c1ccc(Cn2ccc([N+](=O)[O-])n2)cc1",
        "output": "635"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.Nc1cnc2c(c1)CCC2.O=C(Cl)Oc1ccccc1.c1ccncc1>>O=C(Nc1cnc2c(c1)CCC2)Oc1ccccc1",
        "output": "763"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CI.CN(C)C=O.COc1cnc(-c2cc[nH]n2)c2[nH]cc(C(=O)C(=O)N3CCN(c4nnnn4-c4ccccn4)CC3)c12.[H-].[Na+]>>COc1cnc(-c2ccn(C)n2)c2[nH]cc(C(=O)C(=O)N3CCN(c4nnnn4-c4ccccn4)CC3)c12",
        "output": "229"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CN(C)C=O.COC(=O)Cc1c(C)[nH]c2ccccc12.CS(=O)(=O)c1ccc(CBr)c(C(F)(F)F)c1.O.[H-].[I-].[Na+].[Na+]>>COC(=O)Cc1c(C)n(Cc2ccc(S(C)(=O)=O)cc2C(F)(F)F)c2ccccc12",
        "output": "528"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.ClCCl.Nc1cccc2c1CCCC2>>CC(=O)Nc1cccc2c1CCCC2",
        "output": "6"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1cc(Cl)nc(N)n1.Nc1cnc(-c2ccc(C3CCC3)c(O)c2F)cn1>>CC(C)(C)c1cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)nc(N)n1",
        "output": "668"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Nc1cccc(O)c1.CCOC(=O)N=NC(=O)OCC.OC1CCN(c2ccncc2)CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)Nc1cccc(OC2CCN(c3ccncc3)CC2)c1",
        "output": "846"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)Cc1ccc(S(=O)(=O)Cl)cc1.NCc1ccccc1>>CCOC(=O)Cc1ccc(S(=O)(=O)NCc2ccccc2)cc1",
        "output": "530"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C(=O)Cl)c1ccccc1.O=P([O-])([O-])[O-].Oc1ccc(-c2nc(CCl)cs2)cc1>>CN(C(=O)Oc1ccc(-c2nc(CCl)cs2)cc1)c1ccccc1",
        "output": "425"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.CN1CCN(C2CCCNC2)CC1.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[Cl-].[K+].[K+].[NH4+]>>CN1CCN(C2CCCN(c3ccc([N+](=O)[O-])cc3)C2)CC1",
        "output": "26"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)C1CN(C(=O)OC(C)(C)C)CCN1CCc1ccc2c(c1)OCCO2.CCOC(C)=O.Cl.O>>CCOC(=O)C1CNCCN1CCc1ccc2c(c1)OCCO2",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=[N+]([O-])c1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1F.[Na+].[OH-]>>COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1[N+](=O)[O-]",
        "output": "636"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClCCCl.Cn1nnc2cc(C(=O)O)ccc21.NC1CCN(CCn2c(=O)ccc3c(F)cc(F)cc32)CC1.On1nnc2ccccc21>>Cn1nnc2cc(C(=O)NC3CCN(CCn4c(=O)ccc5c(F)cc(F)cc54)CC3)ccc21",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CC(O)c1cc(Cl)c(N(C)C)c(C(C)(C)C)c1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.I[Cu]I.O=C(O)c1ccc(I)cc1O>>CN(C)c1c(Cl)cc(C(O)C#Cc2ccc(C(=O)O)c(O)c2)cc1C(C)(C)C",
        "output": "664"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccccc1C(=O)Cl.Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1.O=C1CC(=O)N(c2ccc(NC(=O)c3ccccc3)cc2)c2ccc3ccccc3c2N1>>COc1ccccc1C(=O)Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1",
        "output": "11"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cn1c(=O)c2c(n(Cc3c(F)cccc3C(F)(F)F)c1=O)COC21CCN(Cc2ccc(Br)o2)CC1)c1ccccc1.N[C@@H](Cn1c(=O)c2c(n(Cc3c(F)cccc3C(F)(F)F)c1=O)CCC21CCN(Cc2cccc(Cl)c2)CC1)c1ccccc1>>N[C@@H](Cn1c(=O)c2c(n(Cc3c(F)cccc3C(F)(F)F)c1=O)COC21CCN(Cc2ccc(Br)o2)CC1)c1ccccc1",
        "output": "793"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(-c2oncc2C(=O)O)cc1.Clc1ccc(C2CCNC2)cc1.O=C(O)C(=O)O>>Cc1ccc(-c2oncc2C(=O)N2CCC(c3ccc(Cl)cc3)C2)cc1",
        "output": "975"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccc(CNC2CCN(Cc3ccccc3)CC2)cc1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.O>>CC(C)(C)OC(=O)N(Cc1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1",
        "output": "867"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)O.CCCCCC.COB(OC)OC.Clc1cccc(Cl)c1Br.O.[Li]CCCC>>OB(O)c1c(Cl)cccc1Cl",
        "output": "789"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Cc1cc2ccncc2c(=O)n1NC(=O)OC(C)(C)C.O.O=C1CCC(=O)N1Br>>Cc1c(Br)c2ccncc2c(=O)n1NC(=O)OC(C)(C)C",
        "output": "518"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC=O.CN(Cc1cn2c(F)cccc2n1)[C@H]1CCCc2cccnc21.Fc1cccc2nc(CN[C@H]3CCCc4cccnc43)cn12>>CCCN(Cc1cn2c(F)cccc2n1)[C@H]1CCCc2cccnc21",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.ClCCl.Nc1cccnc1.O=C(Cl)Oc1ccccc1.c1ccncc1>>O=C(Nc1cccnc1)Oc1ccccc1",
        "output": "763"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCc1cccc(CNS(=O)(=O)c2cccc3cnccc23)c1.CO.Cl>>NCc1cccc(CNS(=O)(=O)c2cccc3cnccc23)c1",
        "output": "793"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C1COCCOCCOCCOCCO1.CN(Cc1c[nH]c(-c2cccnc2C#N)c1F)C(=O)OC(C)(C)C.COc1cccc(S(=O)(=O)Cl)c1.O.[H-].[Na+]>>COc1cccc(S(=O)(=O)n2cc(CN(C)C(=O)OC(C)(C)C)c(F)c2-c2cccnc2C#N)c1",
        "output": "648"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(C)c1ccc(N(C)c2ccc(O)cc2)cc1.Oc1nc(Cl)nc2cnccc12>>COC(C)c1ccc(N(C)c2ccc(Oc3nc(O)c4ccncc4n3)cc2)cc1",
        "output": "542"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O.ClCCl.O=[Cr](=O)([O-])Cl.[Na+].c1cc[nH+]cc1>>COC1=C(OC)C(=O)C(CCCCCCCCCC=O)=C(C)C1=O",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)CCn1cc2c(c1-c1ccccc1)c(=O)n(C)c(=O)n2C.O.[Li+].[OH-]>>Cn1c(=O)c2c(-c3ccccc3)n(CCC(=O)O)cc2n(C)c1=O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)[O-].CCOC(C)=O.Nc1ccc(Br)cc1.O=[N+]([O-])c1ccccc1Br.[Na+]>>O=[N+]([O-])c1ccccc1Nc1ccc(Br)cc1",
        "output": "405"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCO.CCOC(C)=O.O=C(O)c1cncc(Br)c1Br.O=C(n1ccnc1)n1ccnc1>>CCOC(=O)c1cncc(Br)c1Br",
        "output": "47"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "NCC1(c2cncc(F)c2)CCC(F)(F)CC1.O=C(O)c1cccc(Cl)c1Cl>>O=C(NCC1(c2cncc(F)c2)CCC(F)(F)CC1)c1cccc(Cl)c1Cl",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.O=C(O)c1cccnc1.O=S(Cl)Cl>>O=C(O)c1cncc(Br)c1",
        "output": "292"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC[C@H](C)N(Cc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC)[C@H](C)C(=O)O.[Cl-].[NH4+]>>COC[C@H](C)N(Cc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC)[C@H](C)C(N)=O",
        "output": "313"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)c1nn(-c2ccc(C#N)nn2)cc1CCCO.CCCCP(CCCC)CCCC.COC(=O)Cc1cccc(OC)c1O.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>COc1cccc(CC(=O)O)c1OCCCc1cn(-c2ccc(C#N)nn2)nc1C(C)C",
        "output": "928"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)Oc1cccc(C=O)c1.CO.[BH4-].[Na+]>>CC(C)Oc1cccc(CO)c1",
        "output": "356"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Nc1cccc(B(O)O)c1.CC(C)C(O)(c1ccc(Br)cc1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CC(=O)Nc1cccc(-c2ccc(C(O)(c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)C(C)C)cc2)c1",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCNC(C)CC(C)C.ClCCl.Nc1cccc2c1cnn2Cc1ccccc1.O=C(Cl)C(=O)Cl.O=C(O)c1cnc2ccc(F)cn12>>O=C(Nc1cccc2c1cnn2Cc1ccccc1)c1cnc2ccc(F)cn12",
        "output": "889"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CCc1ccc(-c2ccc(N3CCOC3=O)cc2)n1-c1ccc(C(N)=O)cc1C.O.O.[Li+].[OH-]>>Cc1cc(C(N)=O)ccc1-n1c(CCC(=O)O)ccc1-c1ccc(N2CCOC2=O)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1c(N)cccc1-c1ccc(C(N)=O)c2[nH]c3cc(C(=O)N4CCN(C)CC4)ccc3c12.Cc1ccc(N=C=O)cc1C.ClCCl>>Cc1ccc(NC(=O)Nc2cccc(-c3ccc(C(N)=O)c4[nH]c5cc(C(=O)N6CCN(C)CC6)ccc5c34)c2C)cc1C",
        "output": "473"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O=c1ccc2ccc(C#CCO)cc2o1.[Pd]>>O=c1ccc2ccc(CCCO)cc2o1",
        "output": "717"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1=C(C(=O)O)C(c2ccc(Cl)cc2)CC(=O)N1C.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Cl.ClCCCl.Nc1ccc2[nH]ncc2c1>>CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(Cl)cc2)CC(=O)N1C",
        "output": "170"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N1CCc2cc(N)ccc21.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cc1ccc(C(=O)O)c(N2CCC(C)CC2)n1.O.O.On1nnc2ccccc21>>CC(=O)N1CCc2cc(NC(=O)c3ccc(C)nc3N3CCC(C)CC3)ccc21",
        "output": "739"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)NCCCS(=O)(=O)OCC(C)(C)CCCOCc1ccccc1.CC(=O)O.CCO.[H][H].[Pd]>>CC(=O)NCCCS(=O)(=O)OCC(C)(C)CCCO",
        "output": "178"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(Oc1cc(-n2cnc3cnc(CO[Si](C)(C)C(C)(C)C)cc32)sc1C(N)=O)c1ccc(C#N)cc1Cl.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>CC(Oc1cc(-n2cnc3cnc(CO)cc32)sc1C(N)=O)c1ccc(C#N)cc1Cl",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN.CN(C)C=O.COCCOc1c(F)c(Oc2ccc(S(C)(=O)=O)nc2)cc2cc(C3=NCC(CC(=O)O)S3)[nH]c12.Cl.Cl.On1nnc2ccccc21>>CNC(=O)CC1CN=C(c2cc3cc(Oc4ccc(S(C)(=O)=O)nc4)c(F)c(OCCOC)c3[nH]2)S1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C1CCNCC1)S(=O)(=O)c1ccc(Nc2nccc(Nc3ccc(F)cc3)n2)cc1.Cl.O=Cc1cccc(F)c1>>CN(C1CCN(Cc2cccc(F)c2)CC1)S(=O)(=O)c1ccc(Nc2nccc(Nc3ccc(F)cc3)n2)cc1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccccc1NC(=O)c1ccccc1NC(=O)c1ccccc1N.Cl.[Li+].[OH-]>>Nc1ccccc1C(=O)Nc1ccccc1C(=O)Nc1ccccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CCOC(C)=O.Cc1ccc([N+](=O)[O-])cc1C(=O)c1ccc(Br)cc1Cl.Nc1ccc(F)cc1F.O.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Cc1ccc([N+](=O)[O-])cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1Cl",
        "output": "405"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.NCCCNc1ccc2c(NC(=O)CC34CC5CC(CC(C5)C3)C4)cccc2n1.O=C(O)C(F)(F)F.O=C([O-])O.O=Cc1ccccn1.[Na+].[Na+]>>O=C(CC12CC3CC(CC(C3)C1)C2)Nc1cccc2nc(NCCCNCc3ccccn3)ccc12",
        "output": "775"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCN.COc1cc(S(=O)(=O)Cl)ccc1-c1nc2ncncc2[nH]1.Cl>>CCCCNS(=O)(=O)c1ccc(-c2nc3ncncc3[nH]2)c(OC)c1",
        "output": "43"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=CCBr.CC(C)=O.CCOC(=O)c1csc(Nc2cccc(O)c2)n1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1csc(Nc2cccc(OCC=C(C)C)c2)n1",
        "output": "77"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOCC.O=C(O)[C@@H]1CCCN1C(=O)OCc1ccccc1.O=P([O-])([O-])[O-]>>O=C(OCc1ccccc1)N1CCC[C@H]1CO",
        "output": "218"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Fc1cc(Br)ccc1-c1ccccc1.II.O=C=O.[Mg]>>O=C(O)c1ccc(-c2ccccc2)c(F)c1",
        "output": "654"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(C)CN.Cc1ccc(S(=O)(=O)OCC2CCc3ccc(S(C)(=O)=O)cc3O2)cc1>>CC(C)CNCC1CCc2ccc(S(C)(=O)=O)cc2O1",
        "output": "853"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.COC(=O)C(C)(C)CN(c1nc(Cl)ncc1[N+](=O)[O-])C1CCCC1.[Pd]>>COC(=O)C(C)(C)CN(c1nc(Cl)ncc1N)C1CCCC1",
        "output": "660"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.N#Cc1ccc(N=C=O)cc1.Nc1ccccc1NC(=O)Cc1csc(NC(=O)OCc2ccncc2)n1>>N#Cc1ccc(NC(=O)Nc2ccccc2NC(=O)Cc2csc(NC(=O)OCc3ccncc3)n2)cc1",
        "output": "473"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CI.OCc1ccncc1Br.[H-].[Na+]>>COCc1ccncc1Br",
        "output": "140"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.NC1COC1.O=C(NC[C@H](O)CN1CCc2ccccc2C1)c1cc(Cl)ncn1>>O=C(NC[C@H](O)CN1CCc2ccccc2C1)c1cc(NC2COC2)ncn1",
        "output": "166"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)C(=O)Cl.CS(=O)(=O)c1ccc(Oc2ncnc3c2cnn3C2CCNCC2)cc1.O=C(O)C(F)(F)F>>CC(C)(C)C(=O)N1CCC(n2ncc3c(Oc4ccc(S(C)(=O)=O)cc4)ncnc32)CC1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCc3ccccc3)cc1CC2C.Cl.[Na+].[OH-]>>COc1cc2c(cc1OCc1ccccc1)CC(C)n1cc(C(=O)O)c(=O)cc1-2",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)OC(C)C.CCCCCC.COc1ccccc1.ClCCl.Nc1nc(C(=NOCC(=O)O)C(=O)N[C@@H]2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(CCl)CS[C@H]23)ns1.O=C(O)C(F)(F)F>>Nc1nc(C(=NOCC(=O)O)C(=O)N[C@@H]2C(=O)N3C(C(=O)O)=C(CCl)CS[C@H]23)ns1",
        "output": "228"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OB(c2ccc(C(=O)O)cc2)OC1(C)C.CO>>COC(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1",
        "output": "33"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CSc1c(-c2cc(F)cc(F)c2)c(C(C)N2C(=O)c3ccccc3C2=O)nc2ccc(F)cc12.O.O=S([O-])OO.[K+]>>CC(c1nc2ccc(F)cc2c(S(C)(=O)=O)c1-c1cc(F)cc(F)c1)N1C(=O)c2ccccc2C1=O",
        "output": "730"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC#CCOc1ccc(S(=O)(=O)N2CCN(C(=O)N3CCOCC3)CC2C(=O)OCC)cc1.CO.O.O.[Li+].[OH-]>>CC#CCOc1ccc(S(=O)(=O)N2CCN(C(=O)N3CCOCC3)CC2C(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(O)c1ccc(C(=O)O)c(F)c1.CC(O)(c1ccc(C(=O)O)cc1)C(F)(F)F.CN(C)C(=O)N1CC=C(c2cc3c(-c4cccc(NC(=O)c5ccc(C(C)(C)O)cc5F)c4C(O[SiH2]C(C)(C)C)(c4ccccc4)c4ccccc4)ncnc3[nH]2)CC1.Cc1c(N)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)N(C)C)CC3)cc12>>Cc1c(NC(=O)c2ccc(C(C)(O)C(F)(F)F)cc2)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)N(C)C)CC3)cc12",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2.CC(C)(C)[O-].Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(c1ccccc1)c1cncc(Br)c1.[Na+].[Pd].[Pd].c1ccc2c(-c3cccc4ccccc34)cccc2c1>>CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2c1cncc(C(=O)c2ccccc2)c1",
        "output": "597"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CN2CCN1CC2.CC(C)(C)OC(=O)NC1CCNC1.CCO.Clc1ccc2c(Cl)ccnc2c1>>CC(C)(C)OC(=O)NC1CCN(c2ccnc3cc(Cl)ccc23)C1",
        "output": "398"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CC(=O)c1cccc(C#N)c1.CCOCC.O>>N#Cc1cccc(C(=O)CBr)c1",
        "output": "173"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.COc1ccc(C(=O)Nc2cc(N)ccc2C)cc1OC.Cl.ClCCl.O=C(Cl)c1ccc(CCl)cc1>>COc1ccc(C(=O)Nc2cc(NC(=O)c3ccc(CCl)cc3)ccc2C)cc1OC",
        "output": "11"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CS(=O)(=O)N1CCN(C(=O)N2CC(C#N)C(c3ccc(Cl)c(Cl)c3)C2)CC1>>CS(=O)(=O)N1CCN(C(=O)N2CC(CN)C(c3ccc(Cl)c(Cl)c3)C2)CC1",
        "output": "246"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.COc1ccc(Br)cc1CO.c1c[nH]cn1>>COc1ccc(Br)cc1CO[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.C1CCOC1.CC1(C)OCC(CO)CO1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.[H-].[I-].[Na+]>>CC1(C)OCC(COCc2ccccc2)CO1",
        "output": "464"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1C[C@@H](O)C[C@H]1C(=O)Nc1ccc2c(c1)CCC2.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)O[C@H]2C[C@@H](C(=O)Nc3ccc4c(c3)CCC4)N(C(=O)OC(C)(C)C)C2)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(O)c1cc(C(=O)N[C@@H](C)Cn2ccc(-c3ccc(C#N)c(Cl)c3)n2)n[nH]1.CN(C)C=O.CN(C)c1ccncc1.O=C1CCC(=O)O1>>CC(OC(=O)CCC(=O)O)c1cc(C(=O)N[C@@H](C)Cn2ccc(-c3ccc(C#N)c(Cl)c3)n2)n[nH]1",
        "output": "139"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.O.O=[N+]([O-])c1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1N[C@@H]1CCCN(Cc2ccccc2)C1.[Cl-].[Fe].[NH4+]>>Nc1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1N[C@@H]1CCCN(Cc2ccccc2)C1",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CNc1c([N+](=O)[O-])cnc2ccc(OCc3ccccc3)cc12.O=[N+]([O-])c1cnc2cc(OCc3ccccc3)ccc2c1NCCOc1ccccc1>>CNc1c(N)cnc2ccc(OCc3ccccc3)cc12",
        "output": "269"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC1(C(=O)CCCN2CCC(N3Cc4ccccc4C3=O)CC2)c2ccccc2-c2ccccc21.CO.Cl.ClCCl.[BH4-].[Na+]>>CCCC1(C(O)CCCN2CCC(N3Cc4ccccc4C3=O)CC2)c2ccccc2-c2ccccc21",
        "output": "91"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.COc1cc(Cl)cc(C=O)c1.ClCCl.O>>O=Cc1cc(O)cc(Cl)c1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.CCCc1c2c(c(OC)c3c(=O)cc(C(=O)O)oc13)CCCC2.O=C([O-])O.[Na+]>>CCCc1c2c(c(O)c3c(=O)cc(C(=O)O)oc13)CCCC2",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc(Cn2c(-c3ccc(Cl)cc3)nn(CC(=O)NC(C)(C)c3cccc(C(F)(F)F)c3)c2=O)c1.Cl.O.[Na+].[OH-]>>CC(C)(NC(=O)Cn1nc(-c2ccc(Cl)cc2)n(Cc2cccc(C(=O)O)c2)c1=O)c1cccc(C(F)(F)F)c1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)CN(Cc2ccccc2)c2ccc(O)cc21.CCCCCCN=C=O>>CCCCCCNC(=O)Oc1ccc2c(c1)C(C)(C)CN2Cc1ccccc1",
        "output": "104"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cnc(-c2cc3cccc([N+](=O)[O-])c3n2COC)s1.Cl[Fe](Cl)Cl.NN.O.O.O.O.O.O.O>>CCOC(=O)c1cnc(-c2cc3cccc(N)c3n2COC)s1",
        "output": "269"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCNCCCCO.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cn1c2c(c3cc(C(=O)O)ccc31)CC(C1CCOCC1)CC2.F[P-](F)(F)(F)(F)F>>CCN(CCCCO)C(=O)c1ccc2c(c1)c1c(n2C)CCC(C2CCOCC2)C1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.COc1cc(OC)c2c(O)ccnc2c1.Cc1ccccc1.O=P(Cl)(Cl)Cl>>COc1cc(OC)c2c(Cl)ccnc2c1",
        "output": "177"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.C[Si](C)(C)I.ClCCl.Nc1nc(N)c(C(=O)/N=C2\\NC[C@H](CCCCNC(=O)OCc3ccccc3)N2)nc1Cl>>NCCCC[C@H]1CN/C(=N\\C(=O)c2nc(Cl)c(N)nc2N)N1",
        "output": "574"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CCBr.CN(C)C=O.Cc1ccc([N+](=O)[O-])c(O)c1.O=C([O-])[O-].[Cs+].[Cs+]>>C=CCOc1cc(C)ccc1[N+](=O)[O-]",
        "output": "77"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.Nc1ccc2c(-c3cccnc3)csc2c1.c1ccncc1>>CC(=O)Nc1ccc2c(-c3cccnc3)csc2c1",
        "output": "6"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCNCC.COc1c(C)cc(C(=O)c2c(-c3ccc(OCCBr)cc3)oc3ccccc23)cc1C>>CCN(CC)CCOc1ccc(-c2oc3ccccc3c2C(=O)c2cc(C)c(OC)c(C)c2)cc1",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Nc1cc([N+](=O)[O-])c[nH]c1=O.O.O=C(Cl)c1ccccc1.c1ccncc1>>O=C(Nc1cc([N+](=O)[O-])c[nH]c1=O)c1ccccc1",
        "output": "501"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1CN(c2nn(C3CCOCC3)c3c2CN(C(=O)OC(C)(C)C)CC3)c2cc(C#N)c(-c3cnn(C)c3)cc2N1C.ClCCl.O=C(O)C(F)(F)F>>CC1CN(c2nn(C3CCOCC3)c3c2CNCC3)c2cc(C#N)c(-c3cnn(C)c3)cc2N1C",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)Sc1ccc(S(C)(=O)=O)cc1C(=O)O.CS(=O)(=O)c1ccc(N2CCNCC2)c(F)c1>>CC(C)Sc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(S(C)(=O)=O)cc2F)CC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCI.CCO.O=C([O-])[O-].O=CN1CC2CC2(c2ccc(O)cc2)C1.[K+].[K+]>>CCOc1ccc(C23CC2CN(C=O)C3)cc1",
        "output": "198"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C.O=C(Cl)Cl.O=C(Cl)Oc1ccccc1.Oc1ccccc1.[Ti]>>O=C(Oc1ccccc1)Oc1ccccc1",
        "output": "261"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CN.CN(C)C=O.CN1CCOCC1.COC(=O)NCc1cc(F)ccc1COc1cc(C)n(-c2cc(C(=O)O)ccc2C)c(=O)c1Br>>CNC(=O)c1ccc(C)c(-n2c(C)cc(OCc3ccc(F)cc3CNC(=O)OC)c(Br)c2=O)c1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=C1CCCN1C1CCN(CCOc2ccc(O)cc2)CC1.OCCc1ccccc1>>O=C1CCCN1C1CCN(CCOc2ccc(OCCc3ccccc3)cc2)CC1",
        "output": "478"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)COc1cc2ccccc2c2c1c(C(=O)C(N)=O)c(C)n2CC1CCCCC1.Cl.O.[Li+].[OH-]>>Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cc3ccccc3c2n1CC1CCCCC1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cnc(NCC(C)(C)NC(=O)c2ccc(F)cc2)c(Cl)c1.CCOC(C)=O.Cl.O=C([O-])[O-].[BH4-].[K+].[K+].[Li+]>>CC(C)(CNc1ncc(CO)cc1Cl)NC(=O)c1ccc(F)cc1",
        "output": "383"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCOc1ccc(F)c(B(O)O)c1.ClCCl.Cl[Pd]Cl.O=C(O)c1ccc(F)c(Br)n1.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCCOc1ccc(F)c(-c2nc(C(=O)O)ccc2F)c1",
        "output": "869"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCn1c(=O)n(C2CCN(C(=O)OC(C)(C)C)CC2)c2ccccc21.ClC(Cl)Cl.O=C(O)C(F)(F)F>>CCCn1c(=O)n(C2CCNCC2)c2ccccc21",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=C(O)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1.O=c1[nH]c2ccccc2n1C1CCNCC1>>O=C(c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CO.Cc1cc2nc(-c3n[nH]c4c3CN(C(=O)OC(C)(C)C)CC4)[nH]c2cc1C.Cl>>Cc1cc2nc(-c3n[nH]c4c3CNCC4)[nH]c2cc1C",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.Cl.ClCCl.NCCCOc1ccncc1.O=C(Cl)c1cccnc1>>O=C(NCCCOc1ccncc1)c1cccnc1",
        "output": "353"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.COc1cccc(Cn2cc(Br)cn2)c1.ClCCl>>Oc1cccc(Cn2cc(Br)cn2)c1",
        "output": "732"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.C[Si](C)(C)CCOCCl.Cn1cc(-c2cc3c(Cl)c(Cl)cnc3[nH]2)cn1.[H-].[Na+]>>Cn1cc(-c2cc3c(Cl)c(Cl)cnc3n2COCC[Si](C)(C)C)cn1",
        "output": "712"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cc(C=O)c(OC)cc1C.O.O=[Mn](=O)(=O)[O-].[K+].[Na+].[OH-]>>COc1cc(C(=O)O)c(OC)cc1C",
        "output": "384"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOc1cccc(Oc2ccc(C#N)cc2)c1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CCOc1cccc(Oc2ccc(CN)cc2)c1",
        "output": "175"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C[AlH]CC(C)C.Cc1oc(-c2ccc(Br)cc2)nc1CCC=O.Cl.ClCCl>>Cc1oc(-c2ccc(Br)cc2)nc1CCCO",
        "output": "223"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCN1CC[C@@H](c2c(OC)cc(OC)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@@H]1COC(C)=O.CO.[Na+].[OH-]>>CCCN1CC[C@@H](c2c(OC)cc(OC)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@@H]1CO",
        "output": "225"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.CCCCOc1ccc2cc(S)ccc2c1.CCCCOc1ccc2cc([Mg]Br)ccc2c1.CCN(CC)CC.CCOC(C)=O.O.OCCCCCl.[Mg]>>CCCCOc1ccc2cc(SCCCCO)ccc2c1",
        "output": "460"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(-c2ccc(C(=O)N[C@H](c3nnn[nH]3)C3CCCCC3)c(N)c2)cc1.Cc1cc(C)c(N=C=O)c(C)c1.c1ccncc1>>COc1ccc(-c2ccc(C(=O)N[C@H](c3nnn[nH]3)C3CCCCC3)c(NC(=O)Nc3c(C)cc(C)cc3C)c2)cc1",
        "output": "993"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(C)=O.Cn1c2c(c3ccc(Br)cc31)CCCN(C(=O)OC(C)(C)C)C2.I[Cu]I.O=C([O-])[O-].O=c1cc(OCc2ccccc2)cc[nH]1.Oc1cccc2cccnc12.[Cs+].[Cs+]>>Cn1c2c(c3ccc(-n4ccc(OCc5ccccc5)cc4=O)cc31)CCCN(C(=O)OC(C)(C)C)C2",
        "output": "982"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.CSCc1c(F)ccc2c(C(CCOS(C)(=O)=O)c3ccc(Cl)cc3)c[nH]c12.[C-]#N.[K+]>>CSCc1c(F)ccc2c(C(CCC#N)c3ccc(Cl)cc3)c[nH]c12",
        "output": "705"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC1(O)C(=O)CC(c2ccncc2[N+](=O)[O-])OC1C.CCO.[BH4-].[Na+]>>CCC1(O)C(O)CC(c2ccncc2[N+](=O)[O-])OC1C",
        "output": "91"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1nc2ccc(O)cc2s1.O.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCC(C(=O)Nc2nc3ccc(O)cc3s2)CC1",
        "output": "681"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)C=O.Cc1ccccc1.Cl.O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12>>CC(C)(C)[Si](C)(C)Oc1ccc(-c2sc3cc(O)ccc3c2C(=O)c2ccc(OCCN3CCCCC3)cc2)cc1",
        "output": "746"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN1CCC(c2c[nH]c3ccc(N)cc23)CC1.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)Cc1ccc(-c2ccncc2)c2ccccc12>>CN1CCC(c2c[nH]c3ccc(NC(=O)Cc4ccc(-c5ccncc5)c5ccccc45)cc23)CC1",
        "output": "365"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cc1nn2ccc(OCCN)cc2c1-c1nc(-c2ccccc2)c(-c2nc[nH]n2)s1.Cl.Cl.Cn1cnc(C(=O)O)c1.O.On1nnc2ccccc21>>Cc1nn2ccc(OCCNC(=O)c3cn(C)cn3)cc2c1-c1nc(-c2ccccc2)c(-c2nc[nH]n2)s1",
        "output": "697"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-c2ccc(NCCN(C[C@H](O)c3cccc(Cl)c3)C(=O)OC(C)(C)C)cc2)cc1OC1CCCCC1.[Na+].[OH-]>>CC(C)(C)OC(=O)N(CCNc1ccc(-c2ccc(C(=O)O)c(OC3CCCCC3)c2)cc1)C[C@H](O)c1cccc(Cl)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)C1CN(S(=O)(=O)c2ccccc2C(F)(F)F)C(=O)N1c1ccccc1.[Na+].[OH-]>>O=C(O)C1CN(S(=O)(=O)c2ccccc2C(F)(F)F)C(=O)N1c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC=C(C(=O)O)c3ccccc32)CC1.CCN=C=NCCCN(C)C.CN(C)C=O.CNC.Cl.O.O.Oc1cccc2[nH]nnc12>>CN(C)C(=O)C1=CCC2(CCN(C(=O)OC(C)(C)C)CC2)c2ccccc21",
        "output": "517"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cc1ncccc1-c1cc(Cl)ncc1C(=O)O.ClCCl>>Cc1ncccc1-c1cc(Cl)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "893"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CN)c1.O=C(O)c1ccccc1Cl>>Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2ccccc2Cl)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#CCSC.C1CCOC1.CCN(CC)CC.COC(=O)COc1ccc(OC/C=C(/c2ccc(F)cc2)c2ccc(I)cc2)cc1C.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COC(=O)COc1ccc(OC/C=C(/c2ccc(F)cc2)c2ccc(C#CCSC)cc2)cc1C",
        "output": "664"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCOC(C)=O.Cl.Cl.ClC(Cl)Cl.NCCc1nc2ccccc2[nH]1.O=C1OC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1CCc1nc2ccccc2[nH]1",
        "output": "341"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.CO.O=C(O)c1cc(Br)cc(SC2CCCC2)c1>>COC(=O)c1cc(Br)cc(SC2CCCC2)c1",
        "output": "195"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(CO)cc1.Clc1nccnc1N1CCNCC1>>COc1ccc(COc2nccnc2N2CCNCC2)cc1",
        "output": "209"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(C)=O.CCOC(=O)C(C)(C)Br.O=C([O-])[O-].O=[N+]([O-])c1ccc(O)cc1.[K+].[K+]>>CCOC(=O)C(C)(C)Oc1ccc([N+](=O)[O-])cc1",
        "output": "305"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(-c2cccc(C(=O)CC(=O)Nc3cc(-c4ccccc4F)ccc3NC(=O)OC(C)(C)C)c2)nn1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(-c2cccc(C3=Nc4ccc(-c5ccccc5F)cc4NC(=O)C3)c2)nn1",
        "output": "930"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCCCCc1ccccc1.CCC(C)=O.COc1cc(C=O)ccc1O.O.O=C([O-])[O-].[K+].[K+]>>COc1cc(C=O)ccc1OCCCCc1ccccc1",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)OC(=O)N1C[C@H](Cc2ccccc2)[C@@H](CO)C1.CCOCC.ClCCl>>CC(C)(C)OC(=O)N1C[C@H](Cc2ccccc2)[C@@H](C=O)C1",
        "output": "142"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(C)c1=O.ClC(Cl)Cl.NCCCN1CCCC1>>Cn1c(=O)c(C(=O)NCCCN2CCCC2)c(O)c2ncc(Cc3ccc(F)cc3)cc21",
        "output": "498"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)c1nc(-c2ccc(F)c(N)c2)c(-c2ccnc(Cl)n2)s1.CCOC(C)=O.ClCCl.O.O=S(=O)(Cl)c1ccccc1F.c1ccncc1>>CC(C)c1nc(-c2ccc(F)c(NS(=O)(=O)c3ccccc3F)c2)c(-c2ccnc(Cl)n2)s1",
        "output": "68"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(N)CO.ClCCCl.O.O=C([O-])O.O=Cc1ccccc1.[Na+].[Na+]>>CC(C)(CO)NCc1ccccc1",
        "output": "468"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1cc(CO)on1.CN(C)C=O.Clc1ccccc1CBr.[Cl-].[H-].[NH4+].[Na+]>>CCOC(=O)c1cc(COCc2ccccc2Cl)on1",
        "output": "464"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)c2nc3ccccc3n2Cc2ccc(CO[Si](C)(C)C(C)(C)C)o2)CC1.CO.ClCCl.O.[F-].[NH4+]>>CC(C)(C)OC(=O)N1CCC(C(=O)c2nc3ccccc3n2Cc2ccc(CO)o2)CC1",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCOCC.CN1c2ccccc2C(C)(C)C12C=Nc1c(c(CO)cc3ccccc13)O2.ClCCl>>CN1c2ccccc2C(C)(C)C12C=Nc1c(c(C=O)cc3ccccc13)O2",
        "output": "179"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.Clc1nc(Cl)nc(Cl)n1.Nc1ccccc1.O=C([O-])[O-].[Na+].[Na+]>>Clc1nc(Cl)nc(Nc2ccccc2)n1",
        "output": "592"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cn(C2CC2)c2cc(F)c(F)cc2c1=O.O=S(=O)(O)O>>O=C(O)c1cn(C2CC2)c2cc(F)c(F)cc2c1=O",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CNC(=O)[C@@H]1CCCN1.O=C(O)CN1CCN(C(=O)Cc2csc(NC(=O)c3ccc(Cl)cc3)n2)CC1>>CNC(=O)[C@@H]1CCCN1C(=O)CN1CCN(C(=O)Cc2csc(NC(=O)c3ccc(Cl)cc3)n2)CC1",
        "output": "297"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Cn1cc(-c2ccnc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2C=O)cc(Nc2ccncn2)c1=O.[BH4-].[Na+]>>Cn1cc(-c2ccnc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2ccncn2)c1=O",
        "output": "476"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC(C(c2cc(F)cc(F)c2)C(C)(C)C)C1.ClCCl.O=C(O)C(F)(F)F>>CC(C)(C)C(c1cc(F)cc(F)c1)C1CNC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.ClCCl.Cn1cc(Nc2ncc3cnn(Cc4cccc(F)n4)c3n2)cn1>>Cn1cc(Nc2ncc3cnn(Cc4cccc(N5CCOCC5)n4)c3n2)cn1",
        "output": "756"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CCCCCCCC/C=C\\CCCCCCCC(=O)O.[Co+2].[Fe+2].[In+3].[Mn+2].[Sn+4].[Zn+2]>>CCCCCCCC/C=C\\CCCCCCCCO",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.C[C@@H]1CNCCN1C(=O)OC(C)(C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1cccc(-c2ncnc3ccc(Br)cc23)c1>>C[C@@H]1CN(C(=O)c2cccc(-c3ncnc4ccc(Br)cc34)c2)CCN1C(=O)OC(C)(C)C",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CN(C)C=O.O=C1CCC(=O)N1Br.c1ccc(-n2c3ccccc3c3ccccc32)nc1>>Brc1ccc2c(c1)c1ccccc1n2-c1ccccn1",
        "output": "4"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1cccc([C@H]2CCNC[C@H]2c2ccccc2)c1.Cl.O=C(Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](c2cccc(Br)c2)[C@H](c2ccccc2)C1",
        "output": "201"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(COC(C(C)(C)C)C(C)(C)C)NC(=O)OCc1ccccc1.CO.[Pd]>>CC(C)(N)COC(C(C)(C)C)C(C)(C)C",
        "output": "574"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.Cc1ccc(SCCCO)cc1.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cc2nccc(Oc3ccc(NC(=O)OCCCSc4ccc(C)cc4)c(C)c3C)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC#N.Cc1ccc(C(=O)O)cc1.Cc1ccccc1C.O.O.O=Cc1ccc(C(=O)O)cc1.O=[O+][O-]>>O=C(O)c1ccc(C(=O)O)cc1",
        "output": "384"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#Cc1cccc(Nc2ncnc3cc(F)c([N+](=O)[O-])cc23)c1.COCCO.COCC[O-].O.[Na+]>>C#Cc1cccc(Nc2ncnc3cc(OCCOC)c([N+](=O)[O-])cc23)c1",
        "output": "636"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CC1(C)OB(c2cccc3[nH]ccc23)OC1(C)C.CCO.CS(=O)(=O)c1ccc2c(c1)CC(=O)N2.Cc1[nH]c(C=O)c(-c2ccccc2)c1S(C)(=O)=O>>Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(S(C)(=O)=O)cc32)c(-c2ccccc2)c1S(C)(=O)=O",
        "output": "911"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.CN(C)C=O.FC(F)(F)c1cccnc1Cl>>CC(C)(C)OC(=O)N1CCN(c2ncccc2C(F)(F)F)CC1",
        "output": "220"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(F)ccc1F.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>Cc1cc(F)c([N+](=O)[O-])cc1F",
        "output": "103"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(Cl)Cc1ccc(Cl)cc1.[Al+3].[Cl-].[Cl-].[Cl-].c1ccccc1>>O=C(Cc1ccc(Cl)cc1)c1ccccc1",
        "output": "31"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)c1ccc(CO)nc1.Cl.[Na+].[OH-]>>O=C(O)c1ccc(CO)nc1",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C(=O)NC(C(=O)N1CCC2NCC(COc3ccc(F)c(F)c3)C21)C(C)(C)C)N(C)C(=O)OC(C)(C)C.CCN(C(C)C)C(C)C.CN(C)C=O.Clc1ncccn1.O>>CC(C(=O)NC(C(=O)N1CCC2C1C(COc1ccc(F)c(F)c1)CN2c1ncccn1)C(C)(C)C)N(C)C(=O)OC(C)(C)C",
        "output": "36"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#Cc1cnn2c(C(F)(F)F)cc(-c3ccc(Cl)c(C)c3)nc12.CN1CCN(S(=O)(=O)c2ccc(Br)s2)CC1>>Cc1cc(-c2cc(C(F)(F)F)n3ncc(C#Cc4ccc(S(=O)(=O)N5CCN(C)CC5)s4)c3n2)ccc1Cl",
        "output": "766"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@@H](c1cc(Cl)cc(Cl)c1)N1CCC[C@@H](Oc2cc(F)c(C(=O)[O-])cc2C2CC2)C1.C[C@H](c1cc(Cl)cc(Cl)c1)N1CCC[C@@H](Oc2cc(F)c(C(=O)[O-])cc2C2CC2)C1>>C[C@H](c1cc(Cl)cc(Cl)c1)N1CCC[C@@H](Oc2cc(F)c(C(=O)O)cc2C2CC2)C1",
        "output": "151"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#Cc1cccc(N)c1.C1CCOC1.CC(C)S(=O)(=O)c1ccc(Br)cc1[N+](=O)[O-].CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>CC(C)S(=O)(=O)c1ccc(C#Cc2cccc(N)c2)cc1[N+](=O)[O-]",
        "output": "659"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CCN1CCCC1CN.CNS(=O)(=O)c1cc2c(c(C(=O)Cl)c1)OCCO2>>C=CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)NC)cc2c1OCCO2",
        "output": "271"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C#C/C=C/CC(CO)Cc1cccc(OCc2cccc(-c3ccsc3)c2)c1.CCOCC.CI.CN(C)C=O.O.[H-].[Na+]>>COCC(C/C=C/C#CC(C)(C)C)Cc1cccc(OCc2cccc(-c3ccsc3)c2)c1",
        "output": "140"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CC(C)(C)OC(=O)N1CC(=O)C[C@H]1C(=O)O.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CC(=O)C[C@H]1C(=O)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COCCN(CCOC)S(=O)(=O)c1c(Cl)ccc([N+](=O)[O-])c1O.[H][H].[Pd]>>COCCN(CCOC)S(=O)(=O)c1c(Cl)ccc(N)c1O",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.C=CCn1c(-c2ccc(F)cc2)n[nH]c1=O.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CCN(C(C)C)C(C)C.O=Cc1ccc(-c2ccc(Br)cc2)o1.[Pd]>>O=Cc1ccc(-c2ccc(C=CCn3c(-c4ccc(F)cc4)n[nH]c3=O)cc2)o1",
        "output": "539"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN.ClCCl.N#CC1=C(C#N)C(=O)C(Cl)=C(Cl)C1=O.O=Cc1ccccc1-n1nc2c3c(F)ccc(F)c3n(Cc3ccc(-n4cccn4)cc3)cc-2c1=O.[Na+]>>CCNCc1ccccc1-n1nc2c3c(F)ccc(F)c3n(Cc3ccc(-n4cccn4)cc3)cc-2c1=O",
        "output": "468"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CON.O=C(O)c1ccncc1Nc1ccc(I)cc1Cl>>CONC(=O)c1ccncc1Nc1ccc(I)cc1Cl",
        "output": "741"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)C(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C(=O)N1CCCCCN1C(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C(=O)C1(C)C.CCCCCCC.CCOC(C)=O.CCOC(C)=O.Cl[Sn]Cl.O=C([O-])[O-].[Na+].[Na+]>>CC1(C)C(=O)N(c2ccc(N)c(C(F)(F)F)c2)C(=O)N1CCCCCN1C(=O)N(c2ccc(N)c(C(F)(F)F)c2)C(=O)C1(C)C",
        "output": "204"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cccc(C(=O)O)c1C.O=S(=O)(O)O.O=[N+]([O-])O>>Cc1cc([N+](=O)[O-])cc(C(=O)O)c1C",
        "output": "21"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1c(C(C)=O)c(C)n(-c2ccc(O)cc2C)c1C.FCCBr.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1c(C(C)=O)c(C)n(-c2ccc(OCCF)cc2C)c1C",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=O.CCOCC.CC[Mg]Br.CN(C)P(=O)(N(C)C)N(C)C.CSc1ccc(O)cc1.Cc1ccccc1.Cl>>CSc1ccc(O)c(C=O)c1",
        "output": "451"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Cc1c(N2CCC(C(N)c3ncco3)C2)c(F)cc2c(=O)n(N)c(=O)n(C3CC3)c12.ClCCl>>Cc1c(N2CCC(C(NC(=O)OC(C)(C)C)c3ncco3)C2)c(F)cc2c(=O)n(N)c(=O)n(C3CC3)c12",
        "output": "631"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCc1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)N[C@H]4CC[C@@H](N)CC4)c(C)[nH]c23)c1.COCC(=O)Cl.Cl>>CCc1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)N[C@@H]4CC[C@H](NC(=O)COC)CC4)c(C)[nH]c23)c1",
        "output": "45"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.NC1CCN(Cc2ccccc2)CC1.O=C(O)Cc1cccc(F)c1[N+](=O)[O-].O=C(n1ccnc1)n1ccnc1>>O=C(Cc1cccc(F)c1[N+](=O)[O-])NC1CCN(Cc2ccccc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)c1cc2c(cc1NC1CN(C(=O)OC(C)(C)C)C1)N1C(=NNC(=O)[C@@H]1C)CO2.ClCCl.O=C(O)C(F)(F)F>>CC(C)c1cc2c(cc1NC1CNC1)N1C(=NNC(=O)[C@@H]1C)CO2",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CN(C)C=O.O.O=[N+]([O-])c1ccc(Cl)cc1F.Sc1ccccc1>>O=[N+]([O-])c1ccc(Cl)cc1Sc1ccccc1",
        "output": "675"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.O=[N+]([O-])c1ccc(CCCCO)cc1.[H][H].[Pd]>>Nc1ccc(CCCCO)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1cc2nc(-c3ccc([N+](=O)[O-])cc3)[nH]c2cn1.O=C(Cl)C1CCCCCC1.c1ccncc1>>O=C(Nc1cc2nc(-c3ccc([N+](=O)[O-])cc3)[nH]c2cn1)C1CCCCCC1",
        "output": "332"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOP(=O)(C#N)OCC.CN(C)C=O.COC(=O)CCN.Cl.O=C(O)C1CSSC1>>COC(=O)CCNC(=O)C1CSSC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.CCOC(=O)c1cc(N)nc(Cl)c1.CN(C)c1ccncc1.c1ccncc1>>CCOC(=O)c1cc(Cl)nc(NC(C)=O)c1",
        "output": "394"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CCO.COc1ccc2nc(-c3ccc(C)c([N+](=O)[O-])c3)c(-c3ccc(F)cc3)n2n1.O.[Fe]>>COc1ccc2nc(-c3ccc(C)c(N)c3)c(-c3ccc(F)cc3)n2n1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCN(CCOc2ccc3c(c2)C(=O)C(c2cccnc2)=C3c2ccccc2)CC1.ClCCl.O=C(O)C(F)(F)F.[Na+].[OH-]>>O=C1C(c2cccnc2)=C(c2ccccc2)c2ccc(OCCN3CCNCC3)cc21",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N1CCC(Oc2ccc(C3(C(=O)O)CCOCC3)cc2)CC1.CCNCC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O.c1ccncc1>>CCN(CC)C(=O)C1(c2ccc(OC3CCN(C(C)C)CC3)cc2)CCOCC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.Cc1c(CO)cccc1-c1ccc2c(c1)OCCO2.O=Cc1cc(F)c(O)cc1O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1c(COc2cc(O)c(C=O)cc2F)cccc1-c1ccc2c(c1)OCCO2",
        "output": "347"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)C12CCCC(C(=O)OC)(C1)C2>>COC(=O)C12CCCC(C(=O)O)(C1)C2",
        "output": "361"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCOP(=O)(C#N)OCC.CN(C)Cc1cc2c(o1)CNCC2.Cl.Cl.ClCCl.O.O=C(O)c1ccccc1C(=O)c1ccccc1>>CN(C)Cc1cc2c(o1)CN(C(=O)c1ccccc1C(=O)c1ccccc1)CC2",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COc1ccc(CC(=O)N2CCCCC2)cc1CC1COC(C)(C)O1.[C-]#[O+].[Rh].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc([SiH2]c2ccccc2)cc1>>COc1ccc(CCN2CCCCC2)cc1CC1COC(C)(C)O1",
        "output": "112"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1noc(C)c1-c1cncc(Br)c1.[K+]>>Cc1noc(C)c1-c1cncc(B2OC(C)(C)C(C)(C)O2)c1",
        "output": "943"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(N)cc(OC)c1OC.COc1ccc(C(=O)O)cc1O>>COc1ccc(C(=O)Nc2cc(OC)c(OC)c(OC)c2)cc1O",
        "output": "817"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CN1CCC(C(=O)c2cccc(N)c2)CC1.CO.ClCCl.O=C=Nc1ccccc1>>CN1CCC(C(=O)c2cccc(NC(=O)Nc3ccccc3)c2)CC1",
        "output": "473"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C(C(C)C)n1ccc(C(F)(F)F)n1.CCOC(=O)C(CC)n1ccc(C(F)(F)F)n1>>CCC(C(=O)O)n1ccc(C(F)(F)F)n1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COc1ccccc1OCC(O)CN1CCNCC1.Cc1cccc(C)c1NC(=O)CCl>>COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1",
        "output": "340"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)COc1cc(Cl)c(SC#N)cc1C.COC(=O)COc1cc(Cl)c(SCc2ccc(-c3ccc(C(F)(F)F)cc3)cc2)cc1C>>Cc1cc(SCc2ccc(-c3ccc(C(F)(F)F)cc3)cc2)c(Cl)cc1OCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Cl.Cl[Sn]Cl.O.O.O=C(N[C@@H]1CCCN2c3cc(Cl)c([N+](=O)[O-])cc3Oc3ccccc3[C@H]12)C(F)(F)F>>Nc1cc2c(cc1Cl)N1CCC[C@@H](NC(=O)C(F)(F)F)[C@H]1c1ccccc1O2",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOP(=O)(CCNC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)OCC.CN(C)C=O.C[Si](C)(C)Br>>CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NCCP(=O)(O)O)cc1",
        "output": "535"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2cn3nc(N)nc3cn2)cc1.ClCCl.O=C(O)C(F)(F)F>>Nc1ccc(-c2cn3nc(N)nc3cn2)cc1",
        "output": "782"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COC(=O)c1ccc(-c2cc(N)ccc2C)cc1.ClCCl.O=C(Cl)c1ccnc(Cl)c1>>COC(=O)c1ccc(-c2cc(NC(=O)c3ccnc(Cl)c3)ccc2C)cc1",
        "output": "11"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cl.Clc1ccc2ncc(-c3cc4ccccc4o3)n2n1.N[C@H]1C[C@H](CO)C1.[H-].[Na+]>>N[C@H]1C[C@H](COc2ccc3ncc(-c4cc5ccccc5o4)n3n2)C1",
        "output": "407"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ncnn1-c1ccc(C(=O)O)cc1F.Clc1cnc(N2CCC(NC3CC3)CC2)nc1>>Cc1ncnn1-c1ccc(C(=O)N(C2CC2)C2CCN(c3ncc(Cl)cn3)CC2)cc1F",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.COc1ccccc1OCC1CO1.Cl.O=C([O-])[O-].O=C1CCNCC1.[K+].[K+]>>COc1ccccc1OCC(O)CN1CCC(=O)CC1",
        "output": "76"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COCCC#Cc1cc(Cl)c(N)c2c1OCO2.COc1cc2c(Cl)ncnc2cc1OCCCN1CCN(CCF)CC1.C[Si](C)(C)[N-][Si](C)(C)C.[Na+]>>COCCC#Cc1cc(Cl)c(Nc2ncnc3cc(OCCCN4CCN(CCF)CC4)c(OC)cc23)c2c1OCO2",
        "output": "352"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClC(Cl)(Cl)Cl.Nc1cc(C(F)(F)F)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl.O=C1CCC(=O)N1Br>>Nc1c(Br)c(C(F)(F)F)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl",
        "output": "620"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)CNC(=O)c1ccc(Cn2c(C(=O)OC)c(-c3ccccc3)c3cc(Br)ccc3c2=O)cc1.[Na+].[OH-]>>COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(C(=O)NCC(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)N.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.O=C(O)c1cncc(Oc2ccc([N+](=O)[O-])cc2Cl)c1.On1nnc2ccccc21>>CC(C)(C)NC(=O)c1cncc(Oc2ccc([N+](=O)[O-])cc2Cl)c1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)Cc1cccc(OCCCN(Cc2cccc(C(F)(F)F)c2F)CC(c2ccccc2)c2ccccc2)c1.[Na+].[OH-]>>O=C(O)Cc1cccc(OCCCN(Cc2cccc(C(F)(F)F)c2F)CC(c2ccccc2)c2ccccc2)c1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Cc1cc2ccn(COCC[Si](C)(C)C)n2c(=O)c1C#N.N.[Ni]>>Cc1cc2ccn(COCC[Si](C)(C)C)n2c(=O)c1CN",
        "output": "560"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)C1CC1.CO.O=c1ccc2c(-c3ccccc3Cl)cc(OC3CCNCC3)cc2n1-c1c(Cl)cccc1Cl.[BH3-]C#N.[Na+]>>CC(C1CC1)N1CCC(Oc2cc(-c3ccccc3Cl)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c2)CC1",
        "output": "187"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Nc1ccc2ccc(-c3ccc(F)cc3)nc2n1.O.O=C(O)c1ccc(C(F)(F)F)cc1>>O=C(Nc1ccc2ccc(-c3ccc(F)cc3)nc2n1)c1ccc(C(F)(F)F)cc1",
        "output": "744"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.O=C(O)c1cc(C(F)(F)F)ccc1[N+](=O)[O-].[Pd]>>Nc1ccc(C(F)(F)F)cc1C(=O)O",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(Cl)c(O)c1.c1ccc2c(c1)C[C@@H]1NCCC[C@H]21>>O=C(c1ccc(Cl)c(O)c1)N1CCC[C@@H]2c3ccccc3C[C@@H]21",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)C(C)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl.O.[Na+].[OH-]>>CC(Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(C)S(N)(=O)=O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl.O=C(O)c1cc(F)c(F)cc1F>>CCC(C)S(=O)(=O)NC(=O)c1cc(F)c(F)cc1F",
        "output": "580"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)C(F)(F)F.O=C(O)c1ccccc1.[Na+].[OH-].c1nc2[nH]ncc2c2c1CNCC2>>O=C(c1ccccc1)N1CCc2c(cnc3[nH]ncc23)C1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.C[C@H](N)Cn1ccc(-c2cc(F)c(C#N)c(Cl)c2)n1.O.O=C1CCn2cc(C(=O)O)nc2N1.On1nnc2ccccc21>>C[C@@H](Cn1ccc(-c2cc(F)c(C#N)c(Cl)c2)n1)NC(=O)c1cn2c(n1)NC(=O)CC2",
        "output": "697"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cl.ClCCl.O.O=[N+]([O-])c1cc(N2CCCNCC2)ccc1S(=O)(=O)c1cccc(F)c1.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCCN(c2ccc(S(=O)(=O)c3cccc(F)c3)c([N+](=O)[O-])c2)CC1",
        "output": "694"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)c1cc([N+](=O)[O-])ccc1Cl.COC(OC)N(C)C>>CN(C)C=CC(=O)c1cc([N+](=O)[O-])ccc1Cl",
        "output": "576"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(CC)CC.ClCCl.O=S(=O)(Cl)c1ccc(OC(F)(F)F)cc1>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)CC1",
        "output": "99"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COC(=O)CCN(C(=O)c1cc(Cl)cc(OCCN(C(=O)OC(C)(C)C)c2ccncc2)c1)c1ccccc1.Cl.[Na+].[OH-]>>CC(C)(C)OC(=O)N(CCOc1cc(Cl)cc(C(=O)N(CCC(=O)O)c2ccccc2)c1)c1ccncc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1cc(CO)cc(C)n1.ClCCl.O=[Mn]=O>>CCc1cc(C=O)cc(C)n1",
        "output": "179"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COCCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1[N+](=O)[O-].Cl.[Fe].[Na+].[OH-]>>COCCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1N",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.[Pd].c1ccc(CCCCOCCCCCCNCc2ccccc2)cc1>>NCCCCCCOCCCCc1ccccc1",
        "output": "561"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=C(C)C1(C(CCNC(=O)c2ccc(F)c(F)c2)C(=O)O)CCN(CCc2ccccc2)C1=O.CCOC(C)=O.CN(C)C=O.CN1CCOCC1.Cl.ClCCCl.ClCl.NOCc1ccccc1.On1nnc2ccccc21>>C=C(C)C1(C(CCNC(=O)c2ccc(F)c(F)c2)C(=O)NOCc2ccccc2)CCN(CCc2ccccc2)C1=O",
        "output": "480"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CNOC.COCC(=O)O.Cl.ClCCl>>COCC(=O)N(C)OC",
        "output": "54"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(c2nc(COc3ccc(S(C)(=O)=O)cc3)no2)CC1.CC(C)O.CCN(C(C)C)C(C)C.CCc1cnc(Cl)nc1.CS(=O)(=O)c1ccc(OCc2noc(C3CCNCC3)n2)cc1.Cl>>CCc1cnc(N2CCC(c3nc(COc4ccc(S(C)(=O)=O)cc4)no3)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCC1CC1.CC(C)c1ccc(O)c(Br)c1>>CC(C)c1ccc(OCC2CC2)c(Br)c1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCC(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(=O)C1(N)CN(C(=O)OC(C)(C)C)C1.On1nnc2ccccc21>>CCOC(=O)C1(NC(=O)CNC(=O)OC(C)(C)C)CN(C(=O)OC(C)(C)C)C1",
        "output": "107"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCCn1cc(C(=O)O)c2cc(F)cc(C)c21.Cl.O=C(NCc1ccc(F)c(C2CCNCC2)c1)C(F)(F)F>>COCCn1cc(C(=O)N2CCC(c3cc(CNC(=O)C(F)(F)F)ccc3F)CC2)c2cc(F)cc(C)c21",
        "output": "256"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.Cl.ClCCl.Nc1cc(C(F)(F)F)ccc1Br.O.O=C(Cl)c1ccncc1>>O=C(Nc1cc(C(F)(F)F)ccc1Br)c1ccncc1",
        "output": "11"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)OCc1c(-c2cc(Nc3ccc(N4CCN(C5COC5)CC4)cn3)c(=O)n(C)c2)cc(F)cc1N1CCn2c(cc3c2CC(C)(C)C3)C1=O.O.[Li+].[OH-]>>Cn1cc(-c2cc(F)cc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O",
        "output": "497"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.Fc1ccc([Mg]Br)cc1.Nc1cccc(Cl)c1C=O>>Nc1cccc(Cl)c1C(O)c1ccc(F)cc1",
        "output": "309"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)=CCc1cc(C=O)ccc1O.CCN(C(C)C)C(C)C.COCCl>>COCOc1ccc(C=O)cc1CC=C(C)C",
        "output": "375"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)Cc1c(C(=O)c2cccn2C)[nH]c2ccc(Cl)cc12.O.O=C([O-])[O-].[K+].[K+]>>Cn1cccc1C(=O)c1[nH]c2ccc(Cl)cc2c1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)c1ccc2cc(C(=O)NC(c3cccc(C(F)(F)F)c3)C(F)(F)F)oc2c1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)c1ccc2cc(C(=O)NC(c3cccc(C(F)(F)F)c3)C(F)(F)F)oc2c1",
        "output": "752"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CC#N.COC(=O)C1CNCC(C(=O)OC)C1.O=C([O-])[O-].[K+].[K+]>>COC(=O)C1CC(C(=O)OC)CN(Cc2ccccc2)C1",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1ccc2[nH]c3ccc(Br)cc3c2c1.CN(C)C=O.Ic1ccc2c(c1)c1ccccc1n2-c1ccccc1.O=C([O-])[O-].[Cu].[K+].[K+]>>Brc1ccc2c(c1)c1cc(Br)ccc1n2-c1ccc2c(c1)c1ccccc1n2-c1ccccc1",
        "output": "267"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C(Cc1ccc(OCc2nc(-c3cc(C)cc(C)c3)oc2C)cc1C)OCC.[Li+].[OH-]>>CCOC(Cc1ccc(OCc2nc(-c3cc(C)cc(C)c3)oc2C)cc1C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.Cc1ccc(C(=O)O)cc1Br.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1ccc(CO)cc1Br",
        "output": "72"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.Cc1cccc(C(=O)O)n1.O=S(=O)(O)O>>CCOC(=O)c1cccc(C)n1",
        "output": "331"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCc1cc(-c2ccc(S(=O)(=O)Cl)s2)c(C)[nH]c1=O.NCCOc1ccccc1>>CCc1cc(-c2ccc(S(=O)(=O)NCCOc3ccccc3)s2)c(C)[nH]c1=O",
        "output": "600"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)[C@@H]1C[C@H]1c1ccc(OCOCCOC)cc1.CO.[Na+].[OH-]>>COCCOCOc1ccc([C@@H]2C[C@H]2C(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.OC1CCCN(C(c2ccccc2)(c2ccccc2)c2ccccc2)C1>>O=C1CCCN(C(c2ccccc2)(c2ccccc2)c2ccccc2)C1",
        "output": "650"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=C(CCl)CCl.CC(=O)c1ccc(O)c(C=O)c1.CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.Cl.O.O=C([O-])[O-].[I-].[Na+].[Na+]>>C=C(CCl)COc1ccc(C(C)=O)cc1C=O",
        "output": "119"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.Cc1cc(C(=O)Nc2ccc(CO)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1.ClCCl>>Cc1cc(C(=O)Nc2ccc(C=O)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1",
        "output": "179"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COc1cccc([C@H]2S[C@H](CCO)c3nnc(C)n3-c3ccc(Cl)cc32)c1OC.CS(=O)(=O)Cl.ClCCl.O=C([O-])O.[Na+]>>COc1cccc([C@H]2S[C@H](CCOS(C)(=O)=O)c3nnc(C)n3-c3ccc(Cl)cc32)c1OC",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=O.CC(=O)O.CCCCCCCCCc1ccc(O)cc1.CO.C[O-].C[O-].Cc1ccccc1.O.[Mg+2].[Mg]>>CCCCCCCCCc1ccc(O)c(C=O)c1",
        "output": "451"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)CN.CCN(CC)CC.O.O=[N+]([O-])c1cccc(S(=O)(=O)Cl)c1>>CC(C)(C)CNS(=O)(=O)c1cccc([N+](=O)[O-])c1",
        "output": "43"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Nc1cccc(C(=O)Nc2c[nH]nc2C(=O)O)c1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1ccc(S(=O)(=O)O)cc1.N#CCN.O.On1nnc2ccccc21>>CC(=O)Nc1cccc(C(=O)Nc2c[nH]nc2C(=O)NCC#N)c1",
        "output": "816"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(=O)c1c(O)c2cncnc2n(OCc2ccccc2)c1=O.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)c1c(OS(=O)(=O)C(F)(F)F)c2cncnc2n(OCc2ccccc2)c1=O",
        "output": "731"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1ccc2nc(-c3ccc(N)c([N+](=O)[O-])c3)c(N(C)C(C)C)nc2c1.O.[Cl-].[Fe].[NH4+]>>COC(=O)c1ccc2nc(-c3ccc(N)c(N)c3)c(N(C)C(C)C)nc2c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.N#Cc1c(N)cc(C(=O)NCC2CCN(Cc3cnc(-c4ccccc4F)s3)CC2)nc1Cl>>CC(C)Oc1nc(C(=O)NCC2CCN(Cc3cnc(-c4ccccc4F)s3)CC2)cc(N)c1C#N",
        "output": "433"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Cc1nc(CCO)c(C)o1.O.O=[N+]([O-])c1ccc(F)cc1.[H-].[Na+]>>Cc1nc(CCOc2ccc([N+](=O)[O-])cc2)c(C)o1",
        "output": "485"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)CNc1ccc(Cl)c(Cl)c1.Cl>>O=C(O)CNc1ccc(Cl)c(Cl)c1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCC#Cc1cc2c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)ncnc2s1.ClCCl.O=C(O)C(F)(F)F.[Na+].[OH-]>>CNCC#Cc1cc2c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)ncnc2s1",
        "output": "881"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Nc1cc(C#N)cc(N2CCN(C3COC3)C(C(=O)N3CCOCC3)C2)c1Cl.ClCCl.O=C(O)C(F)(F)F>>N#Cc1cc(N)c(Cl)c(N2CCN(C3COC3)C(C(=O)N3CCOCC3)C2)c1",
        "output": "782"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.N.N#Cc1ccc(S(=O)(=O)c2ccccc2)cc1.[Ni]>>NCc1ccc(S(=O)(=O)c2ccccc2)cc1",
        "output": "175"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.CO.COc1ccc(C(=O)c2ccon2)cc1.ClCCl>>O=C(c1ccc(O)cc1)c1ccon1",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.CNc1ccc(Oc2cc(F)ccc2C(=O)OC)cn1.O=C1CCC(=O)N1Cl>>CNc1ncc(Oc2cc(F)ccc2C(=O)OC)cc1Cl",
        "output": "743"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O.O=S(=O)(c1ccccc1)n1cc(-c2ccoc2)c2cc(-c3cccs3)cnc21.[Na+].[OH-]>>c1csc(-c2cnc3[nH]cc(-c4ccoc4)c3c2)c1",
        "output": "831"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CC(=O)C[C@@H]1C(=O)O.CCOC(=O)N1c2ccccc2C=CC1OCC.COC(C)(C)C.Cc1ccccc1.Nc1ccc(-n2ccccc2=O)cc1>>CC(C)(C)OC(=O)N1CC(=O)C[C@@H]1C(=O)Nc1ccc(-n2ccccc2=O)cc1",
        "output": "563"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.Nc1ccccc1C(=O)c1ccccc1.O=BO[O-].[Br-].[K+].[NH4+].[Na+]>>Nc1ccc(Br)cc1C(=O)c1ccccc1",
        "output": "784"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)C[C@H](NC(=O)c1cc(-c2ccc(F)cc2)on1)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CC(C)C[C@H](NC(=O)c1cc(-c2ccc(F)cc2)on1)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(SCc3ccc(Cl)nc3)c2CC1.CCOC(C)=O.NCC1CCCCC1.[Cl-].[NH4+]>>CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(SCc3ccc(NCC4CCCCC4)nc3)c2CC1",
        "output": "70"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.N#Cc1ccc(CCO)cc1Br>>N#Cc1ccc(CC=O)cc1Br",
        "output": "142"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCC(NC(=O)/C(=C/c2ccc(C(=O)O)cc2)COc2cccc3ccccc23)CC1.Cl.NOC1CCCCO1.O=C([O-])[O-].[K+].[K+]>>CN1CCC(NC(=O)/C(=C/c2ccc(C(=O)NOC3CCCCO3)cc2)COc2cccc3ccccc23)CC1",
        "output": "741"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCNC.O=C(O)CCCCCBr>>CCCCN(C)C(=O)CCCCCBr",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)c1ccnc(Cc2ccc3ncc(C#N)cc3c2)c1.Cl.O.O.[Li]O>>N#Cc1cnc2ccc(Cc3cc(C(=O)O)ccn3)cc2c1",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCN(CCN)c1cccc(C)c1.COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.ClC(Cl)Cl.O.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCN(CCNC(=O)Nc1cc(C)c(Oc2ccnc3cc(OC)c(OC)cc23)cc1C)c1cccc(C)c1",
        "output": "913"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(=O)O.CCCCO.CCCCO.CCCCO.CCCCO.CCOC(C)=O.COc1c(F)cc(Cl)cc1C=O.Cc1ccccc1.Nc1cc(F)cc2[nH]c(=O)ccc12.[F-].[NH4+].[Ti]>>COc1c(F)cc(Cl)cc1C=Nc1cc(F)cc2[nH]c(=O)ccc12",
        "output": "329"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.O.O=S(Cl)Cl.OCc1cc(Br)cc(Oc2ccc(C(F)(F)F)cn2)c1>>FC(F)(F)c1ccc(Oc2cc(Br)cc(CCl)c2)nc1",
        "output": "81"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.Cc1ccc(Cl)cc1N.O.O=N[O-].[Na+]>>Cc1ccc(Cl)cc1Br",
        "output": "373"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)S(=O)(=O)Nc1nc(-c2[nH]c(-c3c(Cl)cccc3Cl)nc2-c2ccccc2)ccc1[N+](=O)[O-].CCO.Cl[Sn]Cl.O.O>>CC(C)S(=O)(=O)Nc1nc(-c2[nH]c(-c3c(Cl)cccc3Cl)nc2-c2ccccc2)ccc1N",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@](O)(c2ccc(F)c(F)c2)[C@@H](C(=O)N(Cc2cccc(Cl)c2Cl)C2CC2)C1.CI.CN(C)C=O.[H-].[Na+]>>CO[C@]1(c2ccc(F)c(F)c2)CCN(C(=O)OC(C)(C)C)C[C@@H]1C(=O)N(Cc1cccc(Cl)c1Cl)C1CC1",
        "output": "140"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1=CC2(CCNCC2)c2ccccc21.CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O.CN1CCOCC1.Cl.Cl.ClCCCl.ClCCl.O.On1nnc2ccccc21.[Cl-].[Na+]>>CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(C=Cc3ccccc32)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.O=C(O)C1CCCN(C(=O)c2ccccc2)C1.O=S(Cl)Cl>>O=C(Cl)C1CCCN(C(=O)c2ccccc2)C1",
        "output": "53"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCc1c(CNC)ccc2ccccc12.CN1CC(=O)Nc2ncc(/C=C/C(=O)O)cc2C1.CNCc1sc2ccccc2c1C.Cl.Cl.Nc1ccc(/C=C/C(=O)O)cn1>>Cc1c(CN(C)C(=O)/C=C/c2ccc(N)nc2)sc2ccccc12",
        "output": "811"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1=COCCC1.Cl.OCCCCCCCCCCCl>>ClCCCCCCCCCCOC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=O.CO.N#Cc1ccc(-c2ccc(N3CC[C@@H]4CNC[C@@H]43)cc2)cc1.[BH3-]C#N.[Na+].[Na+].[OH-]>>CC(C)N1C[C@H]2CCN(c3ccc(-c4ccc(C#N)cc4)cc3)[C@H]2C1",
        "output": "187"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.Cl.Fc1ccccc1F.O.O=C(Cl)CCl.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(CCl)c1ccc(F)c(F)c1",
        "output": "31"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC=C(C#N)c3ccccc32)CC1.ClCCl.O=C(O)C(F)(F)F>>N#CC1=CCC2(CCNCC2)c2ccccc21",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)/C=C/c1ccc(Oc2c(-c3ccc(O)cc3)sc3cc(OC)ccc23)cc1.COC(=O)/C=C/c1ccc(Oc2c(-c3ccc(OC)cc3)sc3cc(O)ccc23)cc1.ClCCl.O.[Li+].[OH-]>>COc1ccc(-c2sc3cc(O)ccc3c2Oc2ccc(/C=C/C(=O)O)cc2)cc1",
        "output": "58"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1cccc2cnccc12.Nc1ccnc2ccncc12.O=C(O)C1CCN(c2cccc3cnccc23)CC1>>O=C(Nc1ccnc2ccncc12)C1CCN(c2cccc3cnccc23)CC1",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)CCCc1ccc(-c2ccccc2)c(NC(=O)O[C@@H]2CC[C@@H](NC(=O)OCc3ccccc3)CC2)c1.CCOCC.Cl.O.[Na+].[OH-]>>O=C(O)CCCc1ccc(-c2ccccc2)c(NC(=O)O[C@@H]2CC[C@@H](NC(=O)OCc3ccccc3)CC2)c1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCC1CCCCC1.CC(C)(C)NS(=O)(=O)c1cc[nH]c1.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)NS(=O)(=O)c1ccn(CC2CCCCC2)c1",
        "output": "470"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCN(Cc2ccc(C(F)(F)F)cc2C(=O)C(=O)O)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)C(=O)c1cc(C(F)(F)F)ccc1CN1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1CCCN(c2ccc3c(n2)OCCN(C(=O)OC(C)(C)C)C3)C1.CCOC(C)=O.Cl>>CC1CCCN(c2ccc3c(n2)OCCNC3)C1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CSc1nc(C)c(C#N)c(Cl)n1.Cc1cccc(N)c1>>CSc1nc(C)c(C#N)c(Nc2cccc(C)c2)n1",
        "output": "161"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc(C(F)(F)F)cc1NC(=O)Nc1ccccc1C(F)(F)F.ClCCl.O>>O=C(Nc1cc(C(F)(F)F)ccc1O)Nc1ccccc1C(F)(F)F",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CN1CCOCC1.COc1cccc(CC(=O)O)c1.ClCCCl.N#Cc1ccc(Cc2cncn2C[C@@H]2Cc3ccccc3CN2)cc1.On1nnc2ccccc21>>COc1cccc(CC(=O)N2Cc3ccccc3C[C@H]2Cn2cncc2Cc2ccc(C#N)cc2)c1",
        "output": "633"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CI.CN(C)C=O.CO.C[O-].Oc1ccc(Cl)nc1.[Na+]>>COc1ccc(Cl)nc1",
        "output": "661"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CC(C)(C)OC(=O)N1CCC(NC(=O)Nc2ccc3nc(N[C@@H]4CCc5ccccc54)ccc3c2)CC1",
        "output": "914"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1C(CN)CC2CC1C2(C)C.[C-]#[N+]C(C)C(=O)OC>>[C-]#[N+]C(C)C(=O)NCC1CC2CC(C1C)C2(C)C",
        "output": "392"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCC1CCC(C=Cc2c(C)cc(OCC)c(F)c2F)CC1.Cc1ccccc1.[H][H].[Pd]>>CCCC1CCC(CCc2c(C)cc(OCC)c(F)c2F)CC1",
        "output": "362"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOc1cc(C=O)cc(OCC)c1.Cc1cncc(C(=O)NC2CCNCC2)c1>>CCOc1cc(CN2CCC(NC(=O)c3cncc(C)c3)CC2)cc(OCC)c1",
        "output": "567"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CC[C@@H](N)CC1.Cc1cc(-c2ncnc3c(C(=O)O)c(C)n(COCC[Si](C)(C)C)c23)c(OCC2CC2)cc1F>>Cc1cc(-c2ncnc3c(C(=O)N[C@H]4CC[C@@H](NC(=O)OC(C)(C)C)CC4)c(C)n(COCC[Si](C)(C)C)c23)c(OCC2CC2)cc1F",
        "output": "737"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1ccccc1N1CCNCC1.Cl.ClCCl.O=CCCCC1CC(c2cccc([N+](=O)[O-])c2)=NO1.[Na+]>>COc1ccccc1N1CCN(CCCCC2CC(c3cccc([N+](=O)[O-])c3)=NO2)CC1",
        "output": "484"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.Cl[Pd]Cl.Cn1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2Cl)=N/O)ccc1=O.O.O=C(O)c1ccc(B(O)O)cc1.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)c2cc[cH-]c2)cc1.c1ccc(P(c2ccccc2)c2cc[cH-]c2)cc1>>Cn1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2Cl)=N/O)ccc1=O",
        "output": "837"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(=O)c1ccccc1F.O.O=S(=O)(O)O.O=[N+]([O-])O>>CCC(=O)c1cc([N+](=O)[O-])ccc1F",
        "output": "21"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CI.Nc1nnc(-c2cc(O)cc(OC(F)(F)F)c2)c(-c2ccccc2)n1.Oc1ccccc1>>COc1cc(OC(F)(F)F)cc(-c2nnc(N)nc2-c2ccccc2)c1",
        "output": "62"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1cccc2[nH]c(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)nc12.[I-].[Li+].c1ccncc1>>CC(C)(C)[Si](OCc1nc2c(C(=O)O)cccc2[nH]1)(c1ccccc1)c1ccccc1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCc1ccc(-c2cc3ccccc3c(=O)[nH]2)cc1.O=P(Cl)(Cl)Cl>>CCCCc1ccc(-c2cc3ccccc3c(Cl)n2)cc1",
        "output": "100"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CO.O=[N+]([O-])c1ccc(Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)nc1.O=[Pt]=O>>Nc1ccc(Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)nc1",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)c1ccncc1.COc1ccc(Br)cc1O.ClCCl>>COc1ccc(Br)cc1O[Si](C)(C)C(C)(C)C",
        "output": "746"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.ClCCl.Ic1ccc(OC2CCNCC2)cc1.[Na+].[Na+].[OH-]>>CC(C)N1CCC(Oc2ccc(I)cc2)CC1",
        "output": "187"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc(Nc2nc([C@@H](N)CC(C)C)cs2)ccc1-n1cnc(C)c1.Cl.Cl.Cl.O=S(=O)(Cl)Cc1ccccc1>>COc1cc(Nc2nc([C@H](CC(C)C)NS(=O)(=O)Cc3ccccc3)cs2)ccc1-n1cnc(C)c1",
        "output": "493"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#CCCCCCCCCCO.C1=COCCC1.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O.[Cl-].[Na+]>>C#CCCCCCCCCCOC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.O=Cc1ncccc1F.[BH4-].[Na+]>>OCc1ncccc1F",
        "output": "745"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.O=C(O)c1cccc(Br)c1.O=Cc1cccc(C=Cc2ccc3ccc(Cl)cc3n2)c1.[Li][Li]>>O=C(O)c1cccc(C(O)c2cccc(C=Cc3ccc4ccc(Cl)cc4n3)c2)c1",
        "output": "379"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CS(C)=O.Cn1c2c(c3ccc(Br)cc31)CCN(C(=O)OC(C)(C)C)CC2.O=C([O-])[O-].O=c1cc(-c2ccc(C(F)(F)F)nn2)cc[nH]1.Oc1cccc2cccnc12.[Cs+].[Cs+].[Cu]I>>Cn1c2c(c3ccc(-n4ccc(-c5ccc(C(F)(F)F)nn5)cc4=O)cc31)CCN(C(=O)OC(C)(C)C)CC2",
        "output": "982"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1ccc(Cl)c(C(=O)O)c1F.ClCCl.O.[Na+].[OH-]>>O=C(O)c1c(Cl)ccc(O)c1F",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrB(Br)Br.CC=C(C)C.COc1ccccc1Oc1ccnc(Nc2nc(C)cs2)c1.ClCCl.O.O=C([O-])O.[Na+]>>Cc1csc(Nc2cc(Oc3ccccc3O)ccn2)n1",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)NS(=O)(=O)c1cccc(-c2cn(-c3nc(-c4ccc(Cl)cc4)cc(C(F)(F)F)n3)cn2)c1.ClCCl.O=C(O)C(F)(F)F>>NS(=O)(=O)c1cccc(-c2cn(-c3nc(-c4ccc(Cl)cc4)cc(C(F)(F)F)n3)cn2)c1",
        "output": "680"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(=O)(=O)c1ccc(N)cc1.O=[N+]([O-])c1ccc(C=Cc2nc(Cl)c3cc(F)c(N4CCOCC4)cc3n2)o1>>CS(=O)(=O)c1ccc(Nc2nc(/C=C/c3ccc([N+](=O)[O-])o3)nc3cc(N4CCOCC4)c(F)cc23)cc1",
        "output": "352"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCCCCCNC(=O)[C@@H]1C[C@H]1c1ccc([N+](=O)[O-])cc1.[Fe]>>CCCCCCCCCCNC(=O)[C@@H]1C[C@H]1c1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(Cl)nc1.OCCNCCO>>O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(N(CCO)CCO)nc1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)S(=O)(=O)c1ccc(F)cc1.O=C1CCC(=O)N1Br.O=S(=O)(O)O>>CN(C)S(=O)(=O)c1ccc(F)c(Br)c1",
        "output": "4"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)c1cccnc1-c1ccc(OC)c(C#N)c1.Cl.O.[Na+].[OH-]>>COc1ccc(-c2ncccc2C(=O)O)cc1C#N",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCc1cc(CCC=O)nn1-c1ccccc1.CCN(C(C)C)C(C)C.Clc1ccc(N2CCNCC2)cc1Cl.[Na+]>>CCCc1cc(CCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)nn1-c1ccccc1",
        "output": "484"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cl[Sn]Cl.O=C(/C=C/c1ccc([N+](=O)[O-])c(O)c1)Nc1cccc(Cl)c1>>Nc1ccc(/C=C/C(=O)Nc2cccc(Cl)c2)cc1O",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.CCN(CC)CC.CCO.CN(CCOc1c(Cl)nc(Cl)nc1Cl)C(=O)OC(C)(C)C>>CN(CCOc1c(Cl)nc(Cl)nc1N1CCOCC1)C(=O)OC(C)(C)C",
        "output": "162"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1cc(C(=O)N2CCC3(CC2)CC(=O)c2cc(Br)ccc2O3)nc2c(OC)cccc12.Cl[Pd]Cl.[Fe+2].[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1cc(C(=O)N2CCC3(CC2)CC(=O)c2cc(B4OC(C)(C)C(C)(C)O4)ccc2O3)nc2c(OC)cccc12",
        "output": "942"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=c1c2sccc2n(Cc2ccc(Cl)nc2)c(=O)n1O.OB(O)c1ccc(OC(F)(F)F)cc1>>O=c1c2sccc2n(Cc2ccc(-c3ccc(OC(F)(F)F)cc3)nc2)c(=O)n1O",
        "output": "865"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)OCCCO.CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.c1ccncc1>>CC(C)(C)[Si](C)(C)OCCC=O",
        "output": "142"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCc1cc(OCOCC[Si](C)(C)C)c(F)cc1B1OC(C)(C)C(C)(C)O1.N#Cc1nn(C2CCCCO2)c2cc(Br)ccc12.O.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCc1cc(OCOCC[Si](C)(C)C)c(F)cc1-c1ccc2c(C#N)nn(C3CCCCO3)c2c1",
        "output": "972"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCCC1CC(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.N=C(NO)c1ccc(F)cc1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCCC1Cc1nc(-c2ccc(F)cc2)no1",
        "output": "895"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)[Si](Cl)(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.O.O=C1COc2cc(O)ccc21.c1c[nH]cn1>>CC(C)[Si](Oc1ccc2c(c1)OCC2=O)(C(C)C)C(C)C",
        "output": "746"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CN=C=O.COc1cc(Cc2c(-c3ccc(N)cc3)sc3cc(O)ccc23)ccc1CN1CCCC1.O=C([O-])O.[Na+]>>CNC(=O)Nc1ccc(-c2sc3cc(O)ccc3c2Cc2ccc(CN3CCCC3)c(OC)c2)cc1",
        "output": "176"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#Cc1ccc(OC)cc1.CC[O-].Cc1ccccc1.N#Cc1ccc(Br)s1.O.[Na+]>>COc1ccc(C#Cc2ccc(C#N)s2)cc1",
        "output": "766"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(N)c1nnc(C2CCCC2)[nH]c1=O.CCCCC(=O)Cl>>CCCCC(=O)NC(CC)c1nnc(C2CCCC2)[nH]c1=O",
        "output": "45"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)C[C@@H](O)C(F)(F)F.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCC[C@@H](O)C(F)(F)F",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1=C(Nc2ccc(C(=O)O)cc2Cl)CCCC1=O.CCOC(C)=O.COc1ccc(N)cc1>>COc1ccc(NC(=O)c2ccc(NC3=C(C)C(=O)CCC3)c(Cl)c2)cc1",
        "output": "817"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cl.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1.O=C(O)c1ccnc2ccccc12>>O=C(N[C@@H]1CC[C@@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1)c1ccnc2ccccc12",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CCOc1ccc2cc3ccc(OCCN(CC)CC)c(Cl)c3nc2c1Cl.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+].[Na+].[OH-]>>CCN(CC)CCOc1ccc2cc3cc([N+](=O)[O-])c(OCCN(CC)CC)c(Cl)c3nc2c1Cl",
        "output": "21"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc([N+](=O)[O-])ccc1C#N.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>N#Cc1ccc([N+](=O)[O-])cc1CBr",
        "output": "29"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)CCN1C(=O)c2cccc3cc4cccc(N)c4c(c23)C1=O.CO.COC(=O)Cl.ClCCl.ClCCl>>COC(=O)Nc1cccc2cc3cccc4c3c(c12)C(=O)N(CCN(C)C)C4=O",
        "output": "102"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#CCOc1ccc(S(=O)(=O)C2(C(=O)OC)CCNCC2)cc1.CCN(CC)CC.CN(C)c1ccccn1.COc1ccc(C(=O)Cl)cc1.ClC(Cl)Cl>>CC#CCOc1ccc(S(=O)(=O)C2(C(=O)OC)CCN(C(=O)c3ccc(OC)cc3)CC2)cc1",
        "output": "201"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCOCCOCCOCCO1.CS(=O)(=O)OC[C@@H]1CC[C@H](CN(Cc2ccccc2)Cc2ccccc2)CC1.CS(C)=O.O.[C-]#N.[Na+]>>N#CC[C@H]1CC[C@@H](CN(Cc2ccccc2)Cc2ccccc2)CC1",
        "output": "705"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CNC.Cc1ccc([N+](=O)[O-])c(C(=O)O)c1.ClCCl.O.O=C(Cl)C(=O)Cl.[Na+].[OH-]>>Cc1ccc([N+](=O)[O-])c(C(=O)N(C)C)c1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)CCCCOc1cccc(-c2ccccc2)c1.O.[Na+].[OH-]>>O=C(O)CCCCOc1cccc(-c2ccccc2)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)Nc1cc(N2C3CCC2COC3)nc(-c2ccc([N+](=O)[O-])cc2)n1.CC(C)O.ClCCl.[Pd]>>CC(C)Nc1cc(N2C3CCC2COC3)nc(-c2ccc(N)cc2)n1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1nc(-n2ccc(OCc3ccccc3)cc2=O)sc1C(=O)O.NCc1ccc(C(F)(F)F)nc1>>Cc1nc(-n2ccc(OCc3ccccc3)cc2=O)sc1C(=O)NCc1ccc(C(F)(F)F)nc1",
        "output": "534"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCBr.O=C([O-])[O-].Oc1ccc2cc[nH]c2c1.[Cs+].[Cs+]>>CCOc1ccc2cc[nH]c2c1",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.OCC1CCCCC1.[Na+]>>COc1cc2ncnc(Oc3ccc(NC(=O)OCC4CCCCC4)cc3)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CNC(=O)c1ccc2c(c1)CC(=O)N2C1CCN(C(=O)OCc2ccccc2)CC1.CO.[Pd]>>CNC(=O)c1ccc2c(c1)CC(=O)N2C1CCNCC1",
        "output": "428"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1CCCC1=O.Cc1ccc2[nH]c(C3CNC3)nc2c1.Cl.Cl.Clc1nccnc1Cl.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1ccc2[nH]c(C3CN(c4nccnc4Cl)C3)nc2c1",
        "output": "505"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(=O)C1(Cc2ccc(Cl)cc2)CCNCC1.Cl.ClCc1ccccc1.O=C([O-])O.[Na+]>>CC(=O)C1(Cc2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1",
        "output": "156"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "N#CCBr.c1cc(N2CCNCC2)ccn1>>N#CCN1CCN(c2ccncc2)CC1",
        "output": "880"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.Cn1c(Cl)nc(-c2ccncc2)cc1=O.c1ccc(COC2CCNC2)cc1>>Cn1c(N2CCC(OCc3ccccc3)C2)nc(-c2ccncc2)cc1=O",
        "output": "36"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CI.OCc1cc(Cl)nc(Cl)c1.[H-].[Na+]>>COCc1cc(Cl)nc(Cl)c1",
        "output": "140"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.NC1CC1.O=C(O)c1ccc(S(=O)(=O)Cl)cc1>>O=C(O)c1ccc(S(=O)(=O)NC2CC2)cc1",
        "output": "43"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.COC(=O)c1cc(C(=O)c2ccc([N+](=O)[O-])cc2)ccc1F.Cl[Fe](Cl)Cl.O.O.O.O.O.O.O.[Fe]>>COC(=O)c1cc(C(=O)c2ccc(N)cc2)ccc1F",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCBr.CCC(C)=O.CCCOc1cc(/C=C/C(=O)OC)ccc1O.O=C([O-])[O-].[K+].[K+]>>CCCOc1cc(/C=C/C(=O)OC)ccc1OCC",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)N1CCc2cc(NC(=O)c3ccc(C)nc3N3CCC(C)CC3)ccc21.CO.Cl>>Cc1ccc(C(=O)Nc2ccc3c(c2)CCN3)c(N2CCC(C)CC2)n1",
        "output": "504"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CO.Cl.Nc1ccccc1NC(=O)c1cccc2c1C(=O)c1ccccc1-2.O.O=N[O-].[N-]=[N+]=[N-].[Na+].[Na+]>>[N-]=[N+]=Nc1ccccc1NC(=O)c1cccc2c1C(=O)c1ccccc1-2",
        "output": "189"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1CCCC(C(=O)O)C1.[Na+].[OH-]>>CC(C)(C)OC(=O)NC1CCCC(C(=O)O)C1",
        "output": "631"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)c1cc(C(C)(C)F)ccn1.[Li+].[OH-]>>CC(C)(F)c1ccnc(C(=O)O)c1",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COCCCOc1cc(N)c([N+](=O)[O-])cc1F.[H][H].[Pd]>>COCCCOc1cc(N)c(N)cc1F",
        "output": "202"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc2[nH]c(S(N)(=O)=O)cc2c1.Cl.c1ccncc1>>NS(=O)(=O)c1cc2cc(O)ccc2[nH]1",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCn1c(=O)c2[nH]c(C3CCC(C(=O)OC)C3)nc2n(CCC)c1=O.CCO.O.[K+].[OH-]>>CCCn1c(=O)c2[nH]c(C3CCC(C(=O)O)C3)nc2n(CCC)c1=O",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)C(CO)n1c(=NC(=O)c2cccc(Cl)c2)sc2ccccc21.[Na+].[OH-]>>O=C(N=c1sc2ccccc2n1C(CO)C(=O)O)c1cccc(Cl)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)CC(=O)c2ccc(O)cc21.CCN(CC)CC.ClCCl.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC1(C)CC(=O)c2ccc(OS(=O)(=O)C(F)(F)F)cc21",
        "output": "843"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CI.CN(C)C=O.O.O=C([O-])[O-].O=c1[nH]cc(Br)cc1Br.[K+].[K+]>>Cn1cc(Br)cc(Br)c1=O",
        "output": "191"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CNCc1ccccc1OC.O=C(O)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1>>COc1ccccc1CN(C)C(=O)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1",
        "output": "794"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(CC)CC.CCOC(C)=O.COc1ccc(CCN2C(=O)C3(CCNCC3)N(C)C2c2ccc(C3CC3)cc2)cc1.NC(=O)CBr.O.O=C(O)C(F)(F)F>>COc1ccc(CCN2C(=O)C3(CCN(CC(N)=O)CC3)N(C)C2c2ccc(C3CC3)cc2)cc1",
        "output": "443"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.COc1cc(N)ccc1C.ClCCl.O=C([O-])O.[Br-].[Br-].[Br-].[Na+]>>COc1cc(N)c(Br)cc1C",
        "output": "784"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)Cn1c(=O)n(C)c(=O)c2c(OCCCOC3CCCCO3)c(Cc3cccnc3)sc21.CO.Cc1ccccc1S(=O)(=O)O>>CC(C)Cn1c(=O)n(C)c(=O)c2c(OCCCO)c(Cc3cccnc3)sc21",
        "output": "543"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CN1CCNCC1.COC(=O)c1ccc(-c2ccc(CCC(=O)Cl)c3cccnc23)cc1.c1ccncc1>>COC(=O)c1ccc(-c2ccc(CCC(=O)N3CCN(C)CC3)c3cccnc23)cc1",
        "output": "125"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(N2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1.[Cl-].[Cl-].[Cl-].[Ti+3]>>Cc1ccc(N2CCN(Cc3ccc(N)cc3)CC2)cc1",
        "output": "507"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCC.CCOC(C)=O.Cc1ccc(S(=O)(=O)n2ccc(CO)c2)cc1.ClC(Cl)Cl.[Mn+4].[O-2].[O-2]>>Cc1ccc(S(=O)(=O)n2ccc(C=O)c2)cc1",
        "output": "520"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOc1cc(C(CC(=O)O)N2Cc3cccc(NC(=O)C4CC4)c3C2=O)ccc1OC(F)F.O=C(n1ccnc1)n1ccnc1.[NH4+].[OH-]>>CCOc1cc(C(CC(N)=O)N2Cc3cccc(NC(=O)C4CC4)c3C2=O)ccc1OC(F)F",
        "output": "313"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)OB(c2cccc(N)c2Cl)OC1(C)C.O=[N+]([O-])c1cc(Cl)cc(Br)c1Cl>>Nc1cc(Cl)cc(Br)c1Cl",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.COc1cc(Br)c(O)c(Br)c1.C[Si](C)(C)I>>Oc1cc(Br)c(O)c(Br)c1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)[O-].C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.O=C1CCC(COCc2ccccc2)CC1.[Br-].[K+]>>C=C1CCC(COCc2ccccc2)CC1",
        "output": "601"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCc1cc(-c2ncnn2C)c(C)nc1OC.C[Si](C)(C)Cl.[I-].[Na+]>>CCc1cc(-c2ncnn2C)c(C)[nH]c1=O",
        "output": "758"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1Cn1nnc2cncnc21.ClCCl.O=C(O)C(F)(F)F>>c1ncc2nnn(C[C@@H]3CCCN3)c2n1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)[C@@H]1CCCC[C@H]1N.CO.O=c1c2cc(Cc3ccc(Cl)nc3)c3ccccc3c2ncn1[C@@H]1CCCC[C@H]1O.[Cu]I>>COc1ccc(Cc2cc3c(=O)n([C@@H]4CCCC[C@H]4O)cnc3c3ccccc23)cn1",
        "output": "433"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1nc(N2CCN(Cc3ccc(F)cc3)C2=O)sc1C(=O)O.NCCN1CCCC1.NCc1ccccc1>>Cc1nc(N2CCN(Cc3ccc(F)cc3)C2=O)sc1C(=O)NCCN1CCCC1",
        "output": "534"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(-c2ccc(C(=O)N(C)C)cc2)c1=O.NCCN1CCOCC1>>CN(C)C(=O)c1ccc(-n2c(=O)c(C(=O)NCCN3CCOCC3)c(O)c3ncc(Cc4ccc(F)cc4)cc32)cc1",
        "output": "862"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1CCNCC1.COc1ccc(Br)cc1[N+](=O)[O-].O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COc1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)cc1[N+](=O)[O-]",
        "output": "294"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)CC(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NCc1ccccc1C#Cc1ccnc2[nH]ccc12.On1nnc2ccccc21>>CC(C)(C)CC(=O)NCc1ccccc1C#Cc1ccnc2[nH]ccc12",
        "output": "599"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CC=C(c2cc(F)c3oc(-c4ccc(S(C)(=O)=O)cc4F)nc3c2)CC1.CO.OCC1(O)OC[C@@H](O)[C@@H](O)[C@H]1O.[H][H].[Pd]>>CC(C)(C)OC(=O)N1CCC(c2cc(F)c3oc(-c4ccc(S(C)(=O)=O)cc4F)nc3c2)CC1",
        "output": "806"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNCC1.CC(=O)O.CCO.O=C1CSC(=O)N1.O=Cc1ccc(OCC(O)c2ccccc2)cc1>>O=C1NC(=O)C(=Cc2ccc(OCC(O)c3ccccc3)cc2)S1",
        "output": "761"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CNCCN1.C1COCCO1.CCOc1nc(Cl)nc2c1sc1nc(-c3ccc(OC(C)C)cc3)nc(C)c12>>CCOc1nc(N2CCNCC2)nc2c1sc1nc(-c3ccc(OC(C)C)cc3)nc(C)c12",
        "output": "36"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.COc1ccc(CCN)nc1OC.ClCCCl.ClCCl.O=C(O)CCc1ccc(C(F)(F)F)cc1>>COc1ccc(CCNC(=O)CCc2ccc(C(F)(F)F)cc2)nc1OC",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCOC(=O)c1c(-c2ccccc2)c2ccc(-c3cccc(NC(=O)C(C)(C)C)c3)cc2n1Cc1cccc(OC(F)(F)F)c1.[K+].[OH-]>>CC(C)(C)C(=O)Nc1cccc(-c2ccc3c(-c4ccccc4)c(C(=O)O)n(Cc4cccc(OC(F)(F)F)c4)c3c2)c1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc(CC(OC)C(=O)O)ccc1OCCCBr.O=c1cc(-c2ccccc2)oc2ccc(O)cc12>>COc1cc(CC(OC)C(=O)O)ccc1OCCCOc1ccc2oc(-c3ccccc3)cc(=O)c2c1",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)Oc1ccc2c(c1)NC(=O)CCC2.O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C([O-])O.O=[N+]([O-])[O-].[K+].[Na+]>>CC(C)Oc1cc2c(cc1[N+](=O)[O-])CCCC(=O)N2",
        "output": "103"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)COc1cc2c(=O)c(C)cn3c4ccc(Br)cc4c(c1)c23.ClCCl>>Cc1cn2c3ccc(Br)cc3c3cc(OCC(=O)O)cc(c1=O)c32",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cc(CC(=O)OC(C)(C)C)ccc1NC(=O)Nc1ccccc1Br.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(CC(=O)O)ccc1NC(=O)Nc1ccccc1Br",
        "output": "278"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc([N+](=O)[O-])cc1C(F)(F)F.O=C1CCC(=O)N1Br>>O=[N+]([O-])c1ccc(CBr)c(C(F)(F)F)c1",
        "output": "29"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N(CCc1ccc([N+](=O)[O-])cc1)Cc1ccccc1>>CC(C)(C)OC(=O)N(CCc1ccc(N)cc1)Cc1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/Cc1c(C)c(O)c2ccccc2c1OC(=O)c1ccccc1.CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.CCOCC.CN(C)c1ccncc1.ClCCl>>CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/Cc1c(C)c(OC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)c2ccccc2c1OC(=O)c1ccccc1",
        "output": "108"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc(CC#N)c(Cl)cc1Cl.Cl.O.[Na+].[OH-]>>COc1cc(CC(=O)O)c(Cl)cc1Cl",
        "output": "259"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cn2c(cc1=O)-c1cc(C3CC3)c(OC)cc1CC2CC.Cl.[Na+].[OH-]>>CCC1Cc2cc(OC)c(C3CC3)cc2-c2cc(=O)c(C(=O)O)cn21",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Br.C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(C(C)C)C(C)C.O.O=C1CCNCC1Br>>CC(C)(C)OC(=O)N1CCC(=O)C(Br)C1",
        "output": "694"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CNC.COCCn1cc(C(=O)C(F)(F)F)c2c(C(=O)O)cccc21>>COCCn1cc(C(=O)C(F)(F)F)c2c(C(=O)N(C)C)cccc21",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@H](CCO)Cc1ccc(C(F)(F)F)cc1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N[C@H](CCO)Cc1ccc(C(F)(F)F)cc1",
        "output": "631"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CCN(CC)CC.Cl.ClCCl.Clc1ccc2c(c1)CNCc1nnc([C@@H]3CC[C@@H](c4ccccc4)CC3)n1-2>>CC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2[C@@H]2CC[C@@H](c3ccccc3)CC2)C1",
        "output": "240"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.Cc1ccc(S(=O)(=O)CCO)cc1.ClCCl.O=C(O)c1cccc(S(=O)(=O)Cl)c1.O=S(Cl)Cl>>Cc1ccc(S(=O)(=O)CCOC(=O)c2cccc(S(=O)(=O)Cl)c2)cc1",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCS.COc1ccc(-c2oc3cc(OC)ccc3c2C(=O)c2ccc(OCCN3CCCCC3)cc2)cc1.ClCCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)oc2cc(O)ccc12",
        "output": "20"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1cc(Br)ccc1C(=O)OC(C)C.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>CC(C)OC(=O)c1ccc(Br)cc1CBr",
        "output": "545"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCO[C@H]1CC[C@@H](N2CCC(Nc3cc(C)c(F)cc3[N+](=O)[O-])CC2)CC1.CCO.NN.O.[Ni]>>CCCO[C@H]1CC[C@@H](N2CCC(Nc3cc(C)c(F)cc3N)CC2)CC1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)S(=O)(=O)N[C@@H]1CCC[C@H]1c1ccc(I)cc1.CCCO.N#Cc1ccc(B(O)O)cc1.O.O=C([O-])[O-].[K+].[K+].[Pd+2]>>CC(C)S(=O)(=O)N[C@@H]1CCC[C@H]1c1ccc(-c2ccc(C#N)cc2)cc1",
        "output": "855"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)C1Cc2ccccc2N1C(=O)NCCCCC1CCSS1.[Na+].[OH-]>>O=C(O)C1Cc2ccccc2N1C(=O)NCCCCC1CCSS1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COCc1ccc(Oc2cc(OC)c3[nH]c(C4=NCC(CC(=O)O)S4)cc3c2)cn1.C[NH3+].Cl.O.On1nnc2ccccc21.[Cl-]>>CNC(=O)CC1CN=C(c2cc3cc(Oc4ccc(COC)nc4)cc(OC)c3[nH]2)S1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc2nccc(Cl)c2c1.ClC(Cl)(Cl)Cl.ClCCl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>Clc1ccnc2ccc(CBr)cc12",
        "output": "29"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.O=Cc1ccc2[nH]ccc2c1.[H-].[Na+]>>Cn1ccc2cc(C=O)ccc21",
        "output": "191"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCOC(C)=O.O.O=c1cc(C(F)(F)F)n2ccnc2n1-c1cc([N+](=O)[O-])c(Cl)cc1F.[Fe]>>Nc1cc(-n2c(=O)cc(C(F)(F)F)n3ccnc23)c(F)cc1Cl",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(O)(CN)C(F)(F)F.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCCC1=O.Cc1ccc(C)n1-c1cc(C(F)(F)F)c(C(F)(F)F)nc1C(=O)O.Cl.F[P-](F)(F)(F)(F)F>>Cc1ccc(C)n1-c1cc(C(F)(F)F)c(C(F)(F)F)nc1C(=O)NCC(C)(O)C(F)(F)F",
        "output": "137"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)Cc1c(C(=O)NC(C)(C)C)[nH]c2ccc(Br)cc12.O.[Li+].[OH-]>>CC(C)(C)NC(=O)c1[nH]c2ccc(Br)cc2c1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(OCc2ccccc2)cn1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.[Na+]>>Cc1ccc(OCc2ccccc2)c[n+]1[O-]",
        "output": "262"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCC(CCO)C(F)(F)F.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.c1ccncc1>>CCCCC(CCOS(=O)(=O)c1ccc(C)cc1)C(F)(F)F",
        "output": "197"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CCOc1cc2c(c3c1OC(C)(C)C3)C(c1cccc(NC(=O)C3CCCNC3)c1)=NC(C)(C)C2.CN=C=O.Cl.Cl.O>>CCOc1cc2c(c3c1OC(C)(C)C3)C(c1cccc(NC(=O)C3CCCN(C(=O)NC)C3)c1)=NC(C)(C)C2",
        "output": "437"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(C=O)cc1.FC(F)(F)c1nnc2ccc(N3CCNCC3)nn12>>CC(C)(C)OC(=O)Nc1ccc(CN2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1",
        "output": "567"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)C(NC(=O)C(CC(C)C)=NO)C(=O)OCC.Cl.O.[Na+].[OH-]>>CCOC(=O)C(NC(=O)C(CC(C)C)=NO)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.O=C(OCC1c2ccccc2-c2ccccc21)n1ccc2cc([N+](=O)[O-])ccc21.[Ni]>>Nc1ccc2c(ccn2C(=O)OCC2c3ccccc3-c3ccccc32)c1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CI.CN(C)C=O.Cc1c[nH]c2ccccc12.[H-].[Na+]>>Cc1cn(C)c2ccccc12",
        "output": "191"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.O=C(OO)c1cccc(Cl)c1.OC1CCCc2ccc(Cl)nc21>>[O-][n+]1c(Cl)ccc2c1C(O)CCC2",
        "output": "262"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COc1ccccc1CN.O=C([O-])[O-].O=[N+]([O-])c1ccccc1F.[K+].[K+]>>COc1ccccc1CNc1ccccc1[N+](=O)[O-]",
        "output": "764"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCCCCCCCCC(=O)Cl.CN(C)CCCN.ClC(Cl)Cl>>CCCCCCCCCCCCCC(=O)NCCCN(C)C",
        "output": "45"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Cc1cc(C(=O)O)ccc1Br.ClCCl.NCCc1ccc(Cl)cc1.O=C(Cl)C(=O)Cl>>Cc1cc(C(=O)NCCc2ccc(Cl)cc2)ccc1Br",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(=O)(=O)c1ccc2nc(-c3ccc(Br)cc3)[nH]c2c1.Cc1cccc(B(O)O)c1>>Cc1cccc(-c2ccc(-c3nc4ccc(S(C)(=O)=O)cc4[nH]3)cc2)c1",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(N)CC1.CCN(C(C)C)C(C)C.CCOC(C)=O.O=C(Cl)OCc1ccccc1>>CC(C)(C)OC(=O)N1CCC(NC(=O)OCc2ccccc2)CC1",
        "output": "479"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(=O)OC(C)=O.Cc1cc(C)c(C(=O)O)c(N)n1.Cl.O.O=C([O-])[O-].[Na+].[Na+]>>CC(=O)Nc1nc(C)cc(C)c1C(=O)O",
        "output": "394"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(O)CCCCO[Si](C)(C)C(C)(C)C.CCOC(C)=O.O=S(=O)([O-])[O-].O=S(=O)([O-])c1ccccc1I.O=S([O-])OO.[K+].[Na+].[Na+].[Na+]>>CC(=O)CCCCO[Si](C)(C)C(C)(C)C",
        "output": "87"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cnc(N2CCC3(CC3)C2)nc1NCc1ccc(OC)c(Cl)c1.CCOC(=O)c1cnc(SC)nc1NCc1ccc(OC)c(Cl)c1>>COc1ccc(CNc2nc(N3CCC4(CC4)C3)ncc2C(=O)O)cc1Cl",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CN(C(=O)c1ccc(C#N)cc1)C1CCN(C(=O)OC(C)(C)C)CC1.Cl.ClCCl.O>>CN(C(=O)c1ccc(C#N)cc1)C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCN=C=O.COC(=O)C(C)c1ccc(-c2ccccc2O)c(F)c1>>CCCCCCNC(=O)Oc1ccccc1-c1ccc(C(C)C(=O)OC)cc1F",
        "output": "104"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCO.COc1cnc2[nH]cc(-c3cc(Cl)nc(Cl)c3)c2c1.N[C@H]1CC[C@H](O)CC1>>COc1cnc2[nH]cc(-c3cc(Cl)nc(N[C@@H]4CC[C@@H](O)CC4)c3)c2c1",
        "output": "70"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C(NCC12CC3CC(CC(C3)C1)C2)c1c(Cl)ccc2nc(N3CCC(O)CC3)ccc12.O=C([O-])O.[Na+]>>CS(=O)(=O)OC1CCN(c2ccc3c(C(=O)NCC45CC6CC(CC(C6)C4)C5)c(Cl)ccc3n2)CC1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.C1COCCO1.N#Cc1ccc(B(O)O)cc1F.Nc1cccc(Br)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>N#Cc1ccc(-c2cccc(N)c2)cc1F",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)C(Cc1ccccc1)c1c(SC(C)(C)C)c2cc(OC)ccc2n1C.[H-]>>COc1ccc2c(c1)c(SC(C)(C)C)c(C(CO)Cc1ccccc1)n2C",
        "output": "225"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCN(C(C)C)C(C)C.COc1cc(N)ccc1C1CCN(C2COC2)CC1.N#Cc1cc(-c2ncnc(Cl)n2)ccc1OC1CCOCC1>>COc1cc(Nc2ncnc(-c3ccc(OC4CCOCC4)c(C#N)c3)n2)ccc1C1CCN(C2COC2)CC1",
        "output": "592"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O.OC(CCl)CCCl.Oc1ccc(Br)cc1.[Na+].[OH-]>>OC(CCCl)COc1ccc(Br)cc1",
        "output": "74"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O.O=C(O)C1(COc2ccc(Br)cc2)CCC1.O=S(=O)(O)O>>O=C1c2cc(Br)ccc2OCC12CCC2",
        "output": "274"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Nc1cccc(C#N)c1C.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>CC(=O)Nc1c([N+](=O)[O-])ccc(C#N)c1C",
        "output": "103"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#CCOc1cc(Cl)ncn1.CN(C)C=O.O=C([O-])[O-].Oc1c(F)c(F)cc(F)c1F.[Cl-].[K+].[K+].[NH4+]>>CC#CCOc1cc(Oc2c(F)c(F)cc(F)c2F)ncn1",
        "output": "668"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CN1CCC(O[Si](C)(C)C(C)(C)C)c2ccc(-c3cccnn3)cc2C1.[F-]>>CN1CCC(O)c2ccc(-c3cccnn3)cc2C1",
        "output": "708"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O=[N+]([O-])c1cc(F)c2c(c1)OCC1CCCN21.[Pd]>>Nc1cc(F)c2c(c1)OCC1CCCN21",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)c1cc(NC(=O)Oc2ccccc2)n(-c2ccc(F)cc2)n1.Cn1c(=O)[nH]c2nccc(Oc3ccc(N)cc3)c21.II>>Cn1c(=O)[nH]c2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(F)cc4)cc3)c21",
        "output": "965"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.CC(C)=CC(C)CCCCCO.CCN(CC)CC.COC(C)(C)C.Cl>>CC(=O)OCCCCCC(C)C=C(C)C",
        "output": "126"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCCOc1c(Cl)cc(-c2csc(-c3ccccc3)n2)cc1Cl.c1c[nH]cn1>>Clc1cc(-c2csc(-c3ccccc3)n2)cc(Cl)c1OCCCn1ccnc1",
        "output": "611"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.COC(=O)c1ccc(C#Cc2cc(Cl)ccc2[N+](=O)[O-])cc1>>COC(=O)c1ccc(C#Cc2cc(Cl)ccc2N)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)[C@H]1[C@@H]2CC[C@@H](C2)N1S(=O)(=O)c1ccc(OC)cc1.CO.Cl.[Na+].[OH-]>>COc1ccc(S(=O)(=O)N2[C@H]3CC[C@H](C3)[C@@H]2C(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCCCCBr.CCOCC.O.OCCCc1ccc2ccccc2n1.[Na+].[OH-]>>BrCCCCCCOCCCc1ccc2ccccc2n1",
        "output": "95"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN=C=NCCCN(C)C.Cc1onc(-c2cccc(F)c2)c1C(=O)O.Cl.ClCCl.Fc1ccccc1N1CCNCC1>>Cc1onc(-c2cccc(F)c2)c1C(=O)N1CCN(c2ccccc2F)CC1",
        "output": "975"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.COC(=O)Cl.Cc1cccc(-c2nc(CN3CCNCC3)no2)c1.ClCCl>>COC(=O)N1CCN(Cc2noc(-c3cccc(C)c3)n2)CC1",
        "output": "219"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cc1ncc2n1C(=O)N(C1CCNCC1)C2.Cl.Cl.O=C(O)CCS(=O)(=O)N1CCc2cc(Cl)ccc2C1.On1nnc2ccccc21>>Cc1ncc2n1C(=O)N(C1CCN(C(=O)CCS(=O)(=O)N3CCc4cc(Cl)ccc4C3)CC1)C2",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.O.O=C([O-])O.[Na+].c1ccc2[nH]c(N3CCCNCC3)nc2c1>>CC(C)(C)OC(=O)N1CCCN(c2nc3ccccc3[nH]2)CC1",
        "output": "694"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCOC(C)=O.CN(C)C=O.OCCCO.c1c[nH]cn1>>CC(C)(C)[Si](OCCCO)(c1ccccc1)c1ccccc1",
        "output": "602"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)n1nc(C(=O)NC2CC2)c2ccc(N)nc21.Cc1ccc(C(=O)Cl)cc1.c1ccncc1>>Cc1ccc(C(=O)Nc2ccc3c(C(=O)NC4CC4)nn(C(C)(C)C)c3n2)cc1",
        "output": "463"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C(=C1CCNCC1)c1nc(-c2ccccc2)no1.CC(C)(C)OC(=O)N1CCC(=Cc2cc3ccccc3o2)CC1>>C(=C1CCNCC1)c1cc2ccccc2o1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCn1c(C=O)nc2c(N3CCOCC3)nc(Cl)nc21.CN(C1CNC1)C(C)(C)C(N)=O.ClCCCl.[Na+]>>CCn1c(CN2CC(N(C)C(C)(C)C(N)=O)C2)nc2c(N3CCOCC3)nc(Cl)nc21",
        "output": "944"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccnc(Cc2cc(C(=O)OC)c3ncc(Cl)cc3c2)c1.Cl.O.O.[Li]O>>COC(=O)c1cc(Cc2cc(C(=O)O)ccn2)cc2cc(Cl)cnc12",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCNCC1.F[P-](F)(F)(F)(F)F.O=C(O)c1cc2cc(Cl)ccc2[nH]1.On1nnc2cccnc21>>CN1CCN(C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1",
        "output": "605"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1ccc(C2CC(C(=O)O)CN(C(=O)N3CCOCC3)C2)cc1.ClCCl.O=S(Cl)Cl>>CCc1ccc(C2CC(C(=O)Cl)CN(C(=O)N3CCOCC3)C2)cc1",
        "output": "53"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.CI.COC(C)(C)C.Cc1ccccc1C(CC(=O)c1cc[nH]c(=O)c1)c1ccc(Br)cc1.O.O=C([O-])[O-].[K+].[K+]>>Cc1ccccc1C(CC(=O)c1ccn(C)c(=O)c1)c1ccc(Br)cc1",
        "output": "191"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.COc1cc(N)c(Cl)cc1C(=O)O.O=C(n1ccnc1)n1ccnc1.OCC1CCN(CC2CCCCC2)CC1.[H-].[Na+]>>COc1cc(N)c(Cl)cc1C(=O)OCC1CCN(CC2CCCCC2)CC1",
        "output": "33"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(N)CCCc1c(Cl)cc(Cl)cc1Cl.Cn1cc(C(=O)O)c(C(F)F)n1.O.c1ccncc1>>CC(CCCc1c(Cl)cc(Cl)cc1Cl)NC(=O)c1cn(C)nc1C(F)F",
        "output": "621"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.Cc1cc(COC(=O)N2CCC(N)CC2)cc(C(F)(F)F)c1.Cl.ClCCl.O=C(Cl)CCCc1c[nH]nn1>>Cc1cc(COC(=O)N2CCC(NC(=O)CCCc3c[nH]nn3)CC2)cc(C(F)(F)F)c1",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COc1cc2c(Oc3ccc(C)cc3C(=O)c3ccccc3)ccnc2cc1OCCCl.NCCO.O.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(Oc3ccc(C)cc3C(=O)c3ccccc3)ccnc2cc1OCCNCCO",
        "output": "279"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)CC1(CC(=O)O)CCC(=O)Nc2ccccc21.CC(C)(C)OC(=O)C[C@H]1CCC(=O)N(CC(=O)[O-])c2ccccc21.CCN.CCOCC.CC[NH3+]>>CC(C)(C)OC(=O)C[C@H]1CCC(=O)N(CC(=O)O)c2ccccc21",
        "output": "151"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCc2[nH]nc(C3=CCCC3)c2C1.CCOC(=O)c1n[nH]c2c1CNCC2.CCOC(C)=O.ClCCl.O=C=Nc1cccc(Cl)c1>>CCOC(=O)c1n[nH]c2c1CN(C(=O)Nc1cccc(Cl)c1)CC2",
        "output": "323"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CON=Cc1nc2cnc3ccccc3c2n1CC(C)C.Cc1ccc(S(=O)(=O)Cl)cc1.ClC(Cl)Cl.ClCCl.O=C(OO)c1cccc(Cl)c1.[NH4+].[OH-]>>CON=Cc1nc2c(N)nc3ccccc3c2n1CC(C)C",
        "output": "959"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.Nc1cccc(OCCCOc2ncnc3scc(-c4ccc(F)cc4)c23)c1.O=C(Cl)C1CC1>>O=C(Nc1cccc(OCCCOc2ncnc3scc(-c4ccc(F)cc4)c23)c1)C1CC1",
        "output": "9"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CS(C)=O.Cl[Sn]Cl.O=c1[nH]c2cc(Br)c([N+](=O)[O-])cc2[nH]c1=O>>Nc1cc2[nH]c(=O)c(=O)[nH]c2cc1Br",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C1(c2ccccc2)CCC(CN)CC1.CO.COc1nc(OC)nc([N+]2(C)CCOCC2)n1.O=C(O)CCCCc1c[nH]c2ccccc12.[Cl-]>>CN(C)C1(c2ccccc2)CCC(CNC(=O)CCCCc2c[nH]c3ccccc23)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CC(C)(C)OC(=O)C(C)(C)Sc1ccc2c(c1)CC(N)C2.ClCCl>>CC(=O)NC1Cc2ccc(SC(C)(C)C(=O)OC(C)(C)C)cc2C1",
        "output": "45"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#Cc1cc(C(=O)O)ccc1CCC.CCO.[Pd]>>CCCc1ccc(C(=O)O)cc1CCC",
        "output": "717"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(Cc2ccccc2)nc(Cl)n1.Nc1ccc(-c2ccncc2)cc1>>Cc1cc(Cc2ccccc2)nc(Nc2ccc(-c3ccncc3)cc2)n1",
        "output": "808"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCO.CO.COc1ccc2ccc(=O)n(CCN3CCC(N)CC3)c2c1.Cl.ClC(Cl)Cl.ClCCl.O=C([O-])O.O=Cc1cc2c(cn1)OCCO2.[Na+].[Na+]>>COc1ccc2ccc(=O)n(CCN3CCC(NCc4cc5c(cn4)OCCO5)CC3)c2c1",
        "output": "775"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCBr.CC(C)=O.CCOCC.CCc1cccc(O)c1[N+](=O)[O-].O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>C=CCOc1cccc(CC)c1[N+](=O)[O-]",
        "output": "77"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)C1CCNCC1.CS(=O)(=O)Cl.ClCCl.c1ccncc1>>CCOC(=O)C1CCN(S(C)(=O)=O)CC1",
        "output": "584"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCO.O.O=[N+]([O-])c1cn(-c2cccnc2)nc1Cl.[Fe]>>Nc1cn(-c2cccnc2)nc1Cl",
        "output": "628"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1scc(Br)c1-c1ncn[nH]1.O=C(O)Cc1cc2ncccc2cc1F>>O=C(Cc1cc2ncccc2cc1F)Nc1scc(Br)c1-c1ncn[nH]1",
        "output": "882"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.Oc1ccccc1-c1nn2cc(-c3ccccc3)nc2s1>>CC(=O)Oc1ccccc1-c1nn2cc(-c3ccccc3)nc2s1",
        "output": "46"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)Cc1ccc(C#N)cc1.[NH4+].[OH-].[OH-].[OH-].[Pd+2]>>COC(=O)Cc1ccc(CN)cc1",
        "output": "175"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.C[C@@H](C(=O)O)C(C)(C)C.Cc1c(NC(=O)c2cccc(C#N)c2)cnc2c1c([C@@H]1CCNC(C)(C)C1)cn2C.Cl.ClCCl>>Cc1c(NC(=O)c2cccc(C#N)c2)cnc2c1c([C@@H]1CCN(C(=O)[C@H](C)C(C)(C)C)C(C)(C)C1)cn2C",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(c1ccc(O)cc1)c1cccc(N2CCC(N)CC2)c1.CO.O.[Na+].[OH-]>>CN(c1ccc(O)cc1)c1cccc(N2CCC(NC(=O)OC(C)(C)C)CC2)c1",
        "output": "631"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.COC(=O)c1ccc(-c2cc(-c3cc(C(C)(C)C)cc(C(C)(C)C)c3)n(-c3ccc(S(C)(=O)=O)cc3)n2)cc1.Cl.O.[Na+].[OH-]>>CC(C)(C)c1cc(-c2cc(-c3ccc(C(=O)O)cc3)nn2-c2ccc(S(C)(=O)=O)cc2)cc(C(C)(C)C)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)Nc2cc(Cl)cnc2-n2cc([N+](=O)[O-])cn2)cc1.CCO.[Pd]>>CC(C)(C)c1ccc(S(=O)(=O)Nc2cc(Cl)cnc2-n2cc(N)cn2)cc1",
        "output": "628"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](O)CC1.CCI.[H-].[Na+]>>CCO[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1",
        "output": "307"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.COCCOCCl.ClCCl.O[C@@H](CC#CCOCc1ccccc1)COc1ccc(F)cc1>>COCCOCO[C@@H](CC#CCOCc1ccccc1)COc1ccc(F)cc1",
        "output": "598"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)[C@@H](N)[C@@H](C)NC(=O)OCC1c2ccccc2-c2ccccc21.Cl.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(C#Cc2ccc(CN3CCC(F)CC3)cc2)cc1>>COC(=O)[C@@H](NC(=O)c1ccc(C#Cc2ccc(CN3CCC(F)CC3)cc2)cc1)[C@@H](C)NC(=O)OCC1c2ccccc2-c2ccccc21",
        "output": "652"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COC(=O)C1(NC(=O)c2nc(-c3ccc(OC)cc3)sc2NC(=O)Nc2c(C)cc(C)cc2C)CCCCC1.Cl.O.[Li+].[OH-]>>COc1ccc(-c2nc(C(=O)NC3(C(=O)O)CCCCC3)c(NC(=O)Nc3c(C)cc(C)cc3C)s2)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccccc1C.O=C(O)c1ccccc1.O=P(Cl)(Cl)Cl>>Cc1ccc(C(=O)c2ccccc2)cc1C",
        "output": "275"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCI.O=Cc1ccc(O)c(F)c1>>CCCOc1ccc(C=O)cc1F",
        "output": "198"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cc1cccc(N)c1O.Cl.O=C([O-])Cc1nc(N2CCOCC2)cc(=O)[nH]1.[Na+].c1ccncc1>>Cc1cccc(NC(=O)Cc2nc(N3CCOCC3)cc(=O)[nH]2)c1O",
        "output": "891"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrC1CCCC1.CN(C)C=O.COc1ccc(C=O)cc1O.O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(C=O)cc1OC1CCCC1",
        "output": "153"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)COC(=O)Cl.CC(C)c1cc(C(=O)C=CC(=O)O)ccc1OCC(=O)Nc1nc2ccccc2s1.CCN(CC)CC.CN1CCNCC1.ClCCl>>CC(C)c1cc(C(=O)C=CC(=O)N2CCN(C)CC2)ccc1OCC(=O)Nc1nc2ccccc2s1",
        "output": "517"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)c1ccc2[nH]ncc2c1.NN.O>>NNC(=O)c1ccc2[nH]ncc2c1",
        "output": "421"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.C[Si](C)(C)CCOCn1ccc2c(C(O)C3CCCCC3)ncnc21.ClCCl>>C[Si](C)(C)CCOCn1ccc2c(C(=O)C3CCCCC3)ncnc21",
        "output": "456"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CNc1ccccc1C(=O)O.II.O>>CNc1ccc(I)cc1C(=O)O",
        "output": "372"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C=C(CC)C(=O)c1ccc(OCC(=O)Cl)c(Cl)c1Cl.NCC(=O)O>>C=C(CC)C(=O)c1ccc(OCC(=O)NCC(=O)O)c(Cl)c1Cl",
        "output": "585"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCN(CC)CC.Cc1ccccc1.O=C(CCCCl)c1ccc(F)cc1.c1cc2c3c(c1)[C@H]1CNCC[C@H]1N3CC2>>O=C(CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1",
        "output": "138"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1cc(Cl)cc(OC)c1.ClCCl>>Oc1cc(O)cc(Cl)c1",
        "output": "20"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)CC(N)CC(C)(C)N1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl.N#Cc1c(Oc2ccc(C(=O)O)cc2Cl)cccc1-c1ccncn1.O.On1nnc2ccccc21>>CC1(C)CC(NC(=O)c2ccc(Oc3cccc(-c4ccncn4)c3C#N)c(Cl)c2)CC(C)(C)N1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccccc1-c1cc(O)ncc1C#N.ClCCl.O=P(Cl)(Cl)Cl>>Cc1ccccc1-c1cc(Cl)ncc1C#N",
        "output": "41"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1cc([N+](=O)[O-])[nH]n1.CCOC(C)=O.[Pd]>>CC(C)(C)OC(=O)Nc1cc(N)[nH]n1",
        "output": "684"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1c[nH]cc(-c2ccccc2)c1=O.CO.Cl.[Na+].[OH-]>>O=C(O)c1c[nH]cc(-c2ccccc2)c1=O",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(Oc1ccccc1)C(=O)Cl.CCC(Oc1ccccc1)C(=O)N=C=S.CCC(Oc1ccccc1)C(=O)O.CCO.COc1cc2nccc(Oc3ccc(N)cc3Cl)c2cc1OC.Cc1ccccc1.O=S(Cl)Cl>>CCC(Oc1ccccc1)C(=O)NC(=S)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(Cl)c1",
        "output": "961"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COc1ccc(C#N)cc1O.Cc1ccccc1.ClCCCN1CCOCC1.O=C([O-])[O-].[K+].[K+]>>COc1ccc(C#N)cc1OCCCN1CCOCC1",
        "output": "74"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CNCCO.N#Cc1c[nH]c2ccc(CCNC(=O)c3ccc(-c4ccnc(Cl)n4)cc3)cc12>>CN(CCO)c1nccc(-c2ccc(C(=O)NCCc3ccc4[nH]cc(C#N)c4c3)cc2)n1",
        "output": "36"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1=C(C)C2C(=O)NC(=O)C2(CCC=O)C=C1.CNCc1cccnc1>>CC1=C(C)C2C(=O)NC(=O)C2(CCCN(C)Cc2cccnc2)C=C1",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.c1cc(CNC2CCCC2)cc(OCC2CO2)c1>>CC(C)(C)OC(=O)N(Cc1cccc(OCC2CO2)c1)C1CCCC1",
        "output": "867"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.Cc1ccc(S(=O)(=O)n2cc(-c3c(C)nn(Cc4cccc(F)c4)c3C)c3cc(-c4ccc(OCCO)c(NS(C)(=O)=O)c4)cnc32)cc1.O.[Li+].[OH-]>>Cc1nn(Cc2cccc(F)c2)c(C)c1-c1c[nH]c2ncc(-c3ccc(OCCO)c(NS(C)(=O)=O)c3)cc12",
        "output": "949"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C(=O)c1ccc(OCCCCCCCCCCCCOc2ccccc2)cc1.CO.O.[Na+].[OH-]>>O=C(O)C(=O)c1ccc(OCCCCCCCCCCCCOc2ccccc2)cc1",
        "output": "472"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1nnc(-c2cc(C(=O)O)c(C)cc2C2CCC2)[nH]1.Cc1nc(C)c(-c2cc(C(=O)O)ccc2C)[nH]1.Cl.Cl.N#Cc1ccc(C2(F)CNC2)cc1.N#Cc1ccc(C2CNC2)cc1>>COc1nnc(-c2cc(C(=O)N3CC(F)(c4ccc(C#N)cc4)C3)c(C)cc2C2CCC2)[nH]1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCNc1nc(NCCc2ccncc2)ncc1C(=O)OCC.CCO.Cl.[Na+].[OH-]>>CCCNc1nc(NCCc2ccncc2)ncc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=[N+]([O-])c1cc(F)ccc1Oc1ccccc1.O=[Pt]=O>>Nc1cc(F)ccc1Oc1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NC1CC=C(c2cn(S(=O)(=O)c3cccc4c3CCO4)c3cccnc23)CC1.ClCCl.O=C(O)C(F)(F)F>>NC1CC=C(c2cn(S(=O)(=O)c3cccc4c3CCO4)c3cccnc23)CC1",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.OCCCN1CCCCC1.[Na+]>>COc1cc2nccc(Oc3cc(C)c(NC(=O)OCCCN4CCCCC4)cc3C)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(=O)COc1ccc(Oc2c(-c3ccccc3)c(C)cc3cc(OC)ccc23)cc1.Cl.[Na+].[OH-]>>COc1ccc2c(Oc3ccc(OCC(=O)O)cc3)c(-c3ccccc3)c(C)cc2c1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CN.Cl.Cl.O.O=[N+]([O-])c1cc(S(=O)(=O)Cl)c(F)cc1F>>CNS(=O)(=O)c1cc([N+](=O)[O-])c(F)cc1F",
        "output": "43"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)(N1CCN(C(=O)OC(C)(C)C)CC1)C(=O)N2.ClCCl.O.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)(N1CCNCC1)C(=O)N2",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCN1.CCCCOc1ncc(C(=O)CBr)cc1-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1.CCN(CC)CC.ClCCl>>CCCCOc1ncc(C(=O)CN2CCOCC2)cc1-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1",
        "output": "413"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.ClCCCl.O.O=[N+]([O-])O.Oc1ccc(Cl)c(F)c1.[Br-]>>O=[N+]([O-])c1cc(Cl)c(F)cc1O",
        "output": "21"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(=O)CC1.N#Cc1ccc(N)cc1>>CC(C)(C)OC(=O)N1CCC(Nc2ccc(C#N)cc2)CC1",
        "output": "469"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COc1ccccc1N1CCN(c2nc(C3CC3)nc3cc(F)c(F)cc23)CC1.[K+].[OH-]>>COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1F",
        "output": "636"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)I.CN(C)C=O.O=C([O-])[O-].Oc1cccc2ncccc12.[K+].[K+]>>CC(C)Oc1cccc2ncccc12",
        "output": "318"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(=O)N(C)C.CC(C)Nn1nnnc1SCC1=C(C(=O)O)N2C(=O)C[C@H]2SC1N.CC(O/N=C(\\C(=O)O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1)C(=O)OC(C)(C)C.CCN(CC)CC.N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nnnn3N)CS[C@H]12.O.On1nnc2ccccc21>>CC(O/N=C(\\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nnnn3N)CS[C@H]12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1)C(=O)OC(C)(C)C",
        "output": "587"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(CCn1cc(-c2cc(C)cnc2F)c(=O)[nH]c1=O)OC.O>>Cc1cnc(F)c(-c2cn(CCC=O)c(=O)[nH]c2=O)c1",
        "output": "234"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COc1cc2c(cc1OC)CC(N(C)CCCNC(=O)Cc1cc(Cl)c(Cl)cc1N)CC2.Cc1ccccc1>>COc1cc2c(cc1OC)CC(N(C)CCCNCCc1cc(Cl)c(Cl)cc1N)CC2",
        "output": "112"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C.CCO.N#Cc1cnc2ccc([N+](=O)[O-])cc2c1Cl.Nc1ccc(F)c(F)c1>>N#Cc1cnc2ccc([N+](=O)[O-])cc2c1Nc1ccc(F)c(F)c1",
        "output": "115"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCCCOc1ccc(Br)cc1.CCO.CCOCC.O=C([O-])[O-].OB(O)c1cccc(F)c1F.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccccc1>>CCCCCCCCOc1ccc(-c2cccc(F)c2F)cc1",
        "output": "837"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NCCN.CCN(C(C)C)C(C)C.CO.Cc1ccccc1.ClCCl.OCc1cc(Cl)ccn1>>CC(C)(C)OC(=O)NCCNc1ccnc(CO)c1",
        "output": "78"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(=O)[C@H](C)C[C@H](N)Cc1ccc(-c2ccccc2)cc1.CN(C)C=O.Cl.Cl.O.O=C(O)c1cc(C(=O)O)nc(O)n1.On1nnc2ccccc21>>CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)c1cc(C(=O)O)nc(O)n1",
        "output": "137"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(CC)CC1CC(c2onc(C(CC(=O)[O-])CC(=O)OC(C)(C)C)c2C2CC2)C1.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cc1ccc(N)c(Cl)c1.Cl.O.On1nnc2ccccc21>>CCC(CC)CC1CC(c2onc(C(CC(=O)Nc3ccc(C)cc3Cl)CC(=O)OC(C)(C)C)c2C2CC2)C1",
        "output": "891"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.Cc1ncc(-c2cccc(N)c2)n1C.Cl.ClCCl.O=C(O)C1=Cc2cc(F)ccc2OCC1>>Cc1ncc(-c2cccc(NC(=O)C3=Cc4cc(F)ccc4OCC3)c2)n1C",
        "output": "170"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.[N-]=[N+]=NCc1ccc(C2(C(F)(F)F)N=N2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NCc1ccc(C2(C(F)(F)F)N=N2)cc1",
        "output": "562"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.COCc1cnc2[nH]ccc2c1.ClCCl.O=S(=O)(Cl)c1ccccc1.[Br-].[Na+].[OH-]>>COCc1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1",
        "output": "354"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(C)=O.Cc1cc(Nc2cc(N[C@H](C)C(N)=O)ccc2C#N)sn1.O=C([O-])[O-].OO.[K+].[K+]>>Cc1cc(Nc2cc(N[C@H](C)C(N)=O)ccc2C(N)=O)sn1",
        "output": "180"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=O.CCOC(C)=O.ClCc1ccccc1Cl.Nc1ccc(O)cc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>Nc1ccc(OCc2ccccc2Cl)cc1[N+](=O)[O-]",
        "output": "49"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCCCCCCC[N+](C)(C)C.CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(Cl)cc1-c1ccccc1Cl.COCC(O)COC.Cc1ccccc1.[Br-].[Na+].[OH-]>>COCC(COC)Oc1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1",
        "output": "433"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCn1c2c(c3cc(C(=O)N(C)CCCC(=O)O)ccc31)CC(C1CCOCC1)CC2.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F>>CCn1c2c(c3cc(C(=O)N(C)CCCC(=O)NC)ccc31)CC(C1CCOCC1)CC2",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CS(C)=O.O=C([O-])[O-].O=Cc1cc(F)c(F)c(F)c1.[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(c2c(F)cc(C=O)cc2F)CC1",
        "output": "26"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.Nc1ccccc1CO.O=C(Cl)CCl>>O=C(CCl)Nc1ccccc1CO",
        "output": "9"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)[O-].CCOC(C)=O.CN(C)CCCl.Cc1ccccc1.O=C([O-])[O-].O=[N+]([O-])c1ccc2cn[nH]c2c1.[K+].[Na+].[Na+]>>CN(C)CCn1ncc2ccc([N+](=O)[O-])cc21",
        "output": "604"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc(F)c(F)c(Nc2ccc(Br)cc2F)c1[N+](=O)[O-].Cl.[Zn]>>COc1cc(F)c(F)c(Nc2ccc(Br)cc2F)c1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.CCCCCCCCCCCCC(C)c1cc(O)c2c(c1)OC(C)(C)c1ccncc1-2.c1ccncc1>>CCCCCCCCCCCCC(C)c1cc(OC(C)=O)c2c(c1)OC(C)(C)c1ccncc1-2",
        "output": "46"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CS(C)=O.Cc1cc(-c2ccc(C(F)(F)F)cc2)ccc1CO.O=S(=O)=O.c1ccncc1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)ccc1C=O",
        "output": "179"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CN(C)C=O.Cc1cc(F)ccc1[N+](=O)[O-].O.O=C([O-])[O-].[K+].[K+]>>Cc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)ccc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.COc1cccc(OCCCO)c1.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>COc1cccc(OCCCOC(=O)Nc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)c1",
        "output": "960"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN1C(=O)C2CCCN2C(=O)c2ccccc21.CCn1c(=O)oc(=O)c2ccccc21.CO.O=C(O)[C@@H]1CCCN1.O=c1[nH]c2ccccc2c(=O)n2cccc12>>CCN1C(=O)C2CCCN2Cc2ccccc21",
        "output": "215"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)[Si](OC[C@@H]1CCCN1c1nnc2ccc(F)cn12)(C(C)C)C(C)C.CN(C)C=O.CO.ClCCl.N.N[C@H]1CC[C@@H](O)c2ccccc21.[H-].[Na+]>>CC(C)[Si](OC[C@@H]1CCCN1c1nnc2ccc(O[C@@H]3CC[C@H](N)c4ccccc43)cn12)(C(C)C)C(C)C",
        "output": "823"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)CCSC(=S)Nc1ccc(Cl)cn1.CO.ClC(Cl)Cl.O.[BH4-].[K+]>>CC(O)CCSC(=S)Nc1ccc(Cl)cn1",
        "output": "91"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCC.CI.CN(C)C=O.O.O=C([O-])[O-].Oc1c(F)cccc1F.[K+].[K+]>>COc1c(F)cccc1F",
        "output": "62"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)OC(=O)Cl.CCN(CC)CC.Cc1ccc2c(N3CC[C@@H](N)C3)nc(-c3ccccc3O)nc2c1.Cc1ccccc1>>Cc1ccc2c(N3CC[C@@H](NC(=O)OC(C)C)C3)nc(-c3ccccc3O)nc2c1",
        "output": "94"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(n2cc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4C4(C(N)=O)CC4)n3)cn2)CC1.ClCCl.O=C(O)C(F)(F)F>>NC(=O)C1(c2ccccc2CCc2nc(Nc3cnn(C4CCNCC4)c3)ncc2C(F)(F)F)CC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "N.O=S(=O)(Cl)c1ccc2c(Cl)cnc(Cl)c2c1>>NS(=O)(=O)c1ccc2c(Cl)cnc(Cl)c2c1",
        "output": "245"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(O)CCl.CCO.O.Oc1ccc(Oc2ccc(Cl)cc2)cc1.[Na+].[OH-]>>CC(C)(O)COc1ccc(Oc2ccc(Cl)cc2)cc1",
        "output": "74"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cl.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1.O=C(O)C1CCC1>>O=C(N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1)C1CCC1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCC.CN(C)C=O.COC(=O)CCCCBr.Cl.O.O=C([O-])[O-].[K+].[K+].c1ccc(CC2CCCNC2)cc1>>COC(=O)CCCCN1CCCC(Cc2ccccc2)C1",
        "output": "73"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(C(=O)Cl)cc1.COc1ccc(C(=O)c2c(-c3ccc(C)cc3)oc3ccccc23)cc1.Cc1ccc(-c2cc3ccccc3o2)cc1>>Cc1ccc(-c2oc3ccccc3c2C(=O)c2ccc(O)cc2)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.NCCc1c[nH]c2c(F)c(F)c(F)c(F)c12.O=Cc1cccc(OCC(F)(F)F)c1.O=S(=O)([O-])[O-].[Na+].[Na+]>>Fc1c(F)c(F)c2c(CCNCc3cccc(OCC(F)(F)F)c3)c[nH]c2c1F",
        "output": "468"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cncc2nc(-c3ccnc(Cl)c3)nc(N3CC[C@H](O)[C@H](O)C3)c12.Nc1ccccc1>>COc1cncc2nc(-c3ccnc(Nc4ccccc4)c3)nc(N3CC[C@H](O)[C@H](O)C3)c12",
        "output": "434"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCc1ccc(-c2ccc(Cl)cc2F)cc1[N+](=O)[O-].CO.O.[Cl-].[NH4+].[Zn]>>CCc1ccc(-c2ccc(Cl)cc2F)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOCC.CN(C)CCN(C)C.COc1ccc(OC)c(C(C)(C)C)c1.II.[Li]CCCC>>COc1cc(C(C)(C)C)c(OC)cc1I",
        "output": "372"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOc1ccnc(Cl)c1.COc1cc(Br)cnc1N1CCN(C)CC1.C[C@H]1CN(C(=O)OC(C)(C)C)CCN1>>CCOc1ccnc(N2CCN(C(=O)OC(C)(C)C)C[C@@H]2C)c1",
        "output": "220"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(CO)(CCOC1CCCCO1)NCc1ccccc1.Cl.[Na+].[OH-]>>CC(CO)(CCO)NCc1ccccc1",
        "output": "543"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)COC2(CCC(O)(CC=O)CC2)OC1.N[C@H]1CCc2ccccc21>>CC1(C)COC2(CCC(O)(CCN[C@H]3CCc4ccccc43)CC2)OC1",
        "output": "627"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.O=C([O-])[O-].[N-]=[N+]=NCCCC1(c2ccccc2)SC(c2cc(F)ccc2F)=NN1c1nc2c(s1)CNCC2.[Na+].[Na+].[Na+]>>CN1CCc2nc(N3N=C(c4cc(F)ccc4F)SC3(CCCN=[N+]=[N-])c3ccccc3)sc2C1",
        "output": "217"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCOC(=O)C1(CN)CCN(C(=O)OC(C)(C)C)CC1.Cl>>CCOC(=O)C1(CN)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(C(=O)Cl)cc1.ClC(Cl)Cl.Nc1ccccc1NCC1CCN(c2ccncc2)CC1.c1ccncc1>>COc1ccc(C(=O)Nc2ccccc2NCC2CCN(c3ccncc3)CC2)cc1",
        "output": "11"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC1(C)OB(c2ccc(CBr)cc2)OC1(C)C.COC(=O)c1ccccc1OCc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.Cc1c(O)c(=O)ccn1C.O=C([O-])[O-].[K+].[K+]>>Cc1c(OCc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)c(=O)ccn1C",
        "output": "623"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC1=C(c2c(F)cc(B3OC(C)(C)C(C)(C)O3)cc2Cl)C(=O)CC1.COCCOC.ClCCl.Cl[Pd]Cl.Clc1ccc(Br)cc1.O.O=P([O-])([O-])[O-].[Fe+2].[K+].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COC1=C(c2c(F)cc(-c3ccc(Cl)cc3)cc2Cl)C(=O)CC1",
        "output": "933"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccccc1.Cc1oc(-c2ccccc2)nc1CCOS(C)(=O)=O.O.O=S(=O)([O-])O.Oc1cccc2c1CCC2.[K+].[OH-]>>Cc1oc(-c2ccccc2)nc1CCOc1cccc2c1CCC2",
        "output": "702"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nc1ccc2sc(-c3cccnc3N)cc2c1.O=C(O)c1ccccc1>>Nc1ncccc1-c1cc2cc(NC(=O)c3ccccc3)ccc2s1",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)CCOc1ccc2c(c1)CCCC2=O.CO.Cl.NO>>CN(C)CCOc1ccc2c(c1)CCCC2=NO",
        "output": "212"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOCC.CCS(=O)(=O)Cl.ClCCl.NCc1cccnc1>>CCS(=O)(=O)NCc1cccnc1",
        "output": "493"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCN.O.O=C1OC(=O)c2ccccc21>>CCCCN1C(=O)c2ccccc2C1=O",
        "output": "341"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCS(=O)(=O)Nc1ncc(C(F)(F)F)cc1N.O=C(Cl)C1CCCCC1>>CCS(=O)(=O)Nc1ncc(C(F)(F)F)cc1NC(=O)C1CCCCC1",
        "output": "422"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.Cl.Cl.ClCCl.O=C(Cl)c1ccc(F)c(F)c1.O[C@@H]1CCCNC1>>O=C(c1ccc(F)c(F)c1)N1CCC[C@@H](O)C1",
        "output": "201"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN.COC(=O)Cc1cncc(-c2ccc(C(F)(F)F)cc2C=O)c1>>CCNCc1cc(C(F)(F)F)ccc1-c1cncc(CC(=O)OC)c1",
        "output": "468"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C[C@]1(c2cc(N)ccc2F)N=C(N)OC[C@H]1F.N#Cc1ccc(C(=O)O)nc1>>C[C@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)OC[C@H]1F",
        "output": "985"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCc1nc(SC)c[nH]1.CN(C)C=NS(=O)(=O)c1ccccc1-c1ccc(CBr)cc1.O.[H-].[Na+]>>CCCCc1nc(SC)cn1Cc1ccc(-c2ccccc2S(=O)(=O)N=CN(C)C)cc1",
        "output": "658"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.Cl.Clc1nc(N2CCOCC2)c2sc(CN3CCNCC3)cc2n1.O=Cc1ncc[nH]1>>Clc1nc(N2CCOCC2)c2sc(CN3CCN(Cc4ncc[nH]4)CC3)cc2n1",
        "output": "944"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CSc1cc(C)nc(SC)c1NC(=O)CN1CCN(CCSc2nc3ccc(OCc4ccccc4)cc3[nH]2)CC1.O=C(O)C(F)(F)F>>CSc1cc(C)nc(SC)c1NC(=O)CN1CCN(CCSc2nc3ccc(O)cc3[nH]2)CC1",
        "output": "23"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)n1nc(C(=O)N[C@H]2C[C@@H](CC(=O)O)N(C(=O)OC(C)(C)C)C2)c2ccccc21.CN>>CNC(=O)C[C@@H]1C[C@H](NC(=O)c2nn(C(C)C)c3ccccc23)CN1C(=O)OC(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.CCN(C(C)C)C(C)C.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cc1nn(-c2ccccc2)c2nc(C3CCNCC3)[nH]c(=O)c12.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>Cc1nn(-c2ccccc2)c2nc(C3CCN(C(=O)C4CCN(C(=O)OC(C)(C)C)CC4)CC3)[nH]c(=O)c12",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CSc1nc(-c2ccnc(F)c2)c(-c2ccc(F)cc2)[nH]1.NC1CCCCC1>>CSc1nc(-c2ccnc(NC3CCCCC3)c2)c(-c2ccc(F)cc2)[nH]1",
        "output": "810"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)NCC(=O)O.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.CO.Cc1ccc(N)c(O)c1.ClC(Cl)Cl>>Cc1ccc(NC(=O)CNC(=O)OC(C)(C)C)c(O)c1",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCc1ccc2c(c1)N(CC1CN(Cc3ccccc3)CCO1)c1ccccc1CC2.Cl.[Pd]>>CCc1ccc2c(c1)N(CC1CNCCO1)c1ccccc1CC2",
        "output": "84"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCOC[C@@H]1CO.CCCCP(CCCC)CCCC.Cc1cc(-c2ccc(O)cc2F)no1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.[Na+].[OH-]>>Cc1cc(-c2ccc(OC[C@H]3COCC[C@@H]3NC(=O)OC(C)(C)C)cc2F)no1",
        "output": "478"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CI.Nc1ncc(-c2ccc(=O)[nH]n2)c(-c2cccs2)n1>>Cn1nc(-c2cnc(N)nc2-c2cccs2)ccc1=O",
        "output": "229"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)N(C)C.CC1(C)C(C(=O)O)C1(C)C.CN(C)C=O.Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(N)cn4n3)ccc2F)n(C)n1.Cl.O=C(Cl)C(=O)Cl.O=C([O-])O.[Na+]>>Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5C(C)(C)C5(C)C)cn4n3)ccc2F)n(C)n1",
        "output": "692"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Nc1ccc2c(c1)CC(=O)N2.Cc1c(C=O)[nH]c2c1C(=O)N(CCN1CCCC1)CCC2>>CC(=O)Nc1ccc2c(c1)/C(=C/c1[nH]c3c(c1C)C(=O)N(CCN1CCCC1)CCC3)C(=O)N2",
        "output": "911"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(CC)CC.C[Si](C)(C)C#N.[O-][n+]1ccc(C(F)(F)F)cc1Cl>>N#Cc1cc(C(F)(F)F)cc(Cl)n1",
        "output": "720"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)C[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2cc(Cl)cc(F)c2[nH]1.[Na+].[OH-]>>O=C(O)C[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2cc(Cl)cc(F)c2[nH]1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)c1cn(C2CC2)c2c(COC(C)=O)c(N3CCOCC3)c(F)cc2c1=O.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cn(C2CC2)c2c(CO)c(N3CCOCC3)c(F)cc2c1=O",
        "output": "497"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(CC)(c1ccc(CCC2(O)CCCCC2)c(C)c1)c1ccc(-c2ccc(CC(=O)OC)c(F)c2)c(C)c1.CO.[Cl-].[NH4+].[Na+].[OH-]>>CCC(CC)(c1ccc(CCC2(O)CCCCC2)c(C)c1)c1ccc(-c2ccc(CC(=O)O)c(F)c2)c(C)c1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC=CCBr.CO.Cc1ccc(O)c2c1CCC2=O.[K+].[OH-]>>CC=CCOc1ccc(C)c2c1C(=O)CC2",
        "output": "77"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "B.C1CCOC1.CSC.Cc1ccc(Br)cc1C(=O)O>>Cc1ccc(Br)cc1CO",
        "output": "72"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1ccc(-c2cc(NC(=O)[C@H]3CCCN3C(=O)OC(C)(C)C)ccc2Cl)cc1.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)Nc1ccc(Cl)c(-c2ccc(C(=O)O)cc2)c1",
        "output": "5"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.O=C(O)c1ccc(-c2cccc(F)c2)nc1.O=S(Cl)Cl>>O=C(Cl)c1ccc(-c2cccc(F)c2)nc1",
        "output": "188"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccccc1.CN(C)C=O.O.O=C(O)c1ccc(F)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>O=C(OCc1ccccc1)c1ccc(F)cc1",
        "output": "403"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1cccc(Cl)c1F.COc1cc(-n2nc(-c3c(F)cccc3Cl)[nH]c2=O)ccc1I>>COc1cc(-n2nc(-c3c(F)cccc3Cl)[nH]c2=O)ccc1C#Cc1cccc(Cl)c1F",
        "output": "664"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1cc(CCc2cc(CCc3cc(CO)cc(CCc4cc(CCc5cc(C(C)(C)C)cc(C(C)(C)C)c5)cc(CCc5cc(C(C)(C)C)cc(C(C)(C)C)c5)c4)c3)cc(CCc3cc(C(C)(C)C)cc(C(C)(C)C)c3)c2)cc(C(C)(C)C)c1.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CC(C)(C)c1cc(CCc2cc(CCc3cc(C=O)cc(CCc4cc(CCc5cc(C(C)(C)C)cc(C(C)(C)C)c5)cc(CCc5cc(C(C)(C)C)cc(C(C)(C)C)c5)c4)c3)cc(CCc3cc(C(C)(C)C)cc(C(C)(C)C)c3)c2)cc(C(C)(C)C)c1",
        "output": "179"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.Cl.O=C(Cl)C1CCCC1.O=c1[nH]nc(-c2ccc(-c3ccc4occc4c3)cc2)n1C[C@@H]1CCNC1>>O=C(C1CCCC1)N1CC[C@@H](Cn2c(-c3ccc(-c4ccc5occc5c4)cc3)n[nH]c2=O)C1",
        "output": "125"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.O=C(Cl)C(=O)Cl.OCc1ccc(-c2noc(-c3cnn(-c4ccccc4)c3C(F)(F)F)n2)cc1>>O=Cc1ccc(-c2noc(-c3cnn(-c4ccccc4)c3C(F)(F)F)n2)cc1",
        "output": "179"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)c1ccncc1.CO.C[C@](O)(c1ccnc(-c2cccc3cc([C@H](N)c4ccccc4Cl)sc23)c1)C(F)(F)F.O=S(=O)(Cl)c1ccc2c(c1)OCCCO2>>C[C@](O)(c1ccnc(-c2cccc3cc([C@H](NS(=O)(=O)c4ccc5c(c4)OCCCO5)c4ccccc4Cl)sc23)c1)C(F)(F)F",
        "output": "530"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)NCCON=C(C(=O)O)c1csc(NC=O)n1.CC(C)(C)OC(=O)NCc1nnc(SCC2=C(C(=O)O)N3C(=O)C(N)[C@H]3SC2)s1.CCOC(C)=O.CN(C)C=O.C[Si](C)(C)C(C(N)=O)[Si](C)(C)C.C[Si](C)(C)CC(N)=O.O=P(Cl)(Cl)Cl>>CC(C)(C)OC(=O)NCCON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CSc3nnc(CNC(=O)OC(C)(C)C)s3)CS[C@H]12)c1csc(NC=O)n1",
        "output": "587"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1ccc(N2CCOCC2)c2c1OCCO2.CO.Cl>>Nc1ccc(N2CCOCC2)c2c1OCCO2",
        "output": "66"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CC1.CCOC(C)=O.CN(C)C=O.CO.COC(=O)c1ccc(C)c(-n2cnc3ccc(N4CCNCC4)cc3c2=O)c1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(C)c(-n2cnc3ccc(N4CCN(CC5CC5)CC4)cc3c2=O)c1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "[N-]=[N+]=NCC1Cc2cc(Cl)c3c(c2O1)CCC3.[Pt]>>NCC1Cc2cc(Cl)c3c(c2O1)CCC3",
        "output": "89"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCOC(C)=O.C[Si](C)(C)Cl.O.O=C(CCI)c1cccc(Cl)c1F.[I-].[Na+]>>OC(CCI)c1cccc(Cl)c1F",
        "output": "24"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.NC(c1cccc(Br)c1)C1(O)CCCC1.O=C(O)c1ncccc1Cl.On1nnc2ccccc21>>O=C(NC(c1cccc(Br)c1)C1(O)CCCC1)c1ncccc1Cl",
        "output": "905"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cl[Sn]Cl.O=[N+]([O-])c1ccc(-n2cc(Cl)nn2)cc1>>Nc1ccc(-n2cc(Cl)nn2)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccccc1N1CCN(CCCCN)CC1.O=[N+]([O-])c1ccc(Cl)cc1Cl>>COc1ccccc1N1CCN(CCCCNc2cc(Cl)ccc2[N+](=O)[O-])CC1",
        "output": "304"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CNC.Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1Cc1cccc(C(=O)O)c1>>Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1Cc1cccc(C(=O)N(C)C)c1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccccc1N(C)C#N.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>CN(C#N)c1ccccc1CBr",
        "output": "29"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CSc1ccc(C(=O)C(C)(C)N2CCCCC2)cc1.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1ccc(C(=O)C(C)(C)N2CCCCC2)cc1",
        "output": "500"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CN(CCN1CCCC1)c1nc2cc([N+](=O)[O-])ccc2o1.[Fe]>>CN(CCN1CCCC1)c1nc2cc(N)ccc2o1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)CCCNC1CN.CCN(C(C)C)C(C)C.CN(C)C=O.Fc1ccc(Br)cn1.O=C([O-])[O-].[K+].[K+]>>CC1(C)CCCNC1CNc1ccc(Br)cn1",
        "output": "810"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCOC(=O)C(C)Br.CS(C)=O.Oc1ccc(O)cc1.[Ca+2].[OH-].[OH-]>>CCCCCOC(=O)C(C)Oc1ccc(O)cc1",
        "output": "455"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)NCCN(C(C)C)C(C)C.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>CC(C)N(CCN(C(C)C)S(=O)(=O)c1ccc([N+](=O)[O-])cc1)C(C)C",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(-n2nccc2CN)cc1.COc1ccc(C[C@H]2NC(=O)n3c2nc2ccccc23)cc1.O=C(O)C(F)(F)F>>COc1ccc(C[C@@H](NC(=O)NCc2ccnn2-c2ccc(OC)cc2)c2nc3ccccc3[nH]2)cc1",
        "output": "999"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)CN.O=C=Nc1ccccc1>>COCCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)CNC(=O)Nc1ccccc1",
        "output": "35"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCN3CC(C)C)cc1.CCN(CC)CC.CCn1ccnc1CSc1ccc(N)cc1.CN(C)C=O.O.O=S(Cl)Cl>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4nccn4CC)cc2)CCN3CC(C)C)cc1",
        "output": "170"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCOC(C)=O.ClCCl.O=[N+]([O-])c1cc(CN2CCOCC2)cc(-c2ccccc2)c1.[H][H].[Pd]>>Nc1cc(CN2CCOCC2)cc(-c2ccccc2)c1",
        "output": "71"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCOC(C)=O.CCOc1cc(-c2ccc(CC(=O)O)c(F)c2)cnc1OCc1ccc(OC)cc1.Nc1cc(-c2cn[nH]c2)cc(C(F)(F)F)c1.O.c1ccncc1>>CCOc1cc(-c2ccc(CC(=O)Nc3cc(-c4cn[nH]c4)cc(C(F)(F)F)c3)c(F)c2)cnc1OCc1ccc(OC)cc1",
        "output": "365"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1CCCCCCOc1ccccc1-c1ccccc1>>NCCCCCCOc1ccccc1-c1ccccc1",
        "output": "242"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Br.C=CC(O)(CC)CCOC(C)CC.CCC(=CCBr)CCOC(C)CC.COCCOC.O=Cc1ccccc1O.[K+].[OH-]>>CCC(=CCOc1ccccc1C=O)CCOC(C)CC",
        "output": "77"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(CC)CC.CCOC(=O)CC1CCc2c1[nH]c1ccc(-c3noc(-c4ccc(OC(F)(F)F)cc4)n3)cc21.O.[Br-].[Li+]>>O=C(O)CC1CCc2c1[nH]c1ccc(-c3noc(-c4ccc(OC(F)(F)F)cc4)n3)cc21",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCO.Cc1cn(Cc2ccc(F)c(Cl)c2)c(=O)c2c(OCc3ccccc3)c3n(c12)CCN(C)C3=O.[Pd]>>Cc1cn(Cc2ccc(F)c(Cl)c2)c(=O)c2c(O)c3n(c12)CCN(C)C3=O",
        "output": "264"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)C1(C#N)CCN(C(=O)OC(C)(C)C)CC1.CCOCC.[Li+].[OH-]>>CC(C)(C)OC(=O)N1CCC(C#N)(C(=O)O)CC1",
        "output": "281"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCC.O=C(O)C(c1ccccc1)c1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCC(c1ccccc1)c1ccccc1",
        "output": "231"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC(NC(=O)OCc2ccccc2)(C(F)(F)F)CC1.CCO.[Pd]>>CC(C)(C)OC(=O)N1CCC(N)(C(F)(F)F)CC1",
        "output": "574"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C1(C(=O)O)CC1.FC(F)(F)c1ccc(C2CNCC(c3nc(C4CC4)no3)C2)cc1>>CN(C)C1(C(=O)N2CC(c3ccc(C(F)(F)F)cc3)CC(c3nc(C4CC4)no3)C2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.CCCCCCC.CCOC(C)=O.CCOc1ccc(S(=O)(=O)NC2CCC(N)(C#N)CC2)cc1C.ClCCl>>CCOc1ccc(S(=O)(=O)NC2CCC(C#N)(NC(C)=O)CC2)cc1C",
        "output": "45"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC[C@@H](C)n1ccc2c([N+](=O)[O-])cccc2c1=O.CCO.O.[Cl-].[Fe].[NH4+]>>CC(=O)OC[C@@H](C)n1ccc2c(N)cccc2c1=O",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(S)CCO.CN(C)C=O.O=C(O)c1ccc(F)c([N+](=O)[O-])c1.O=C([O-])[O-].[K+].[K+]>>CC(C)(CCO)Sc1ccc(C(=O)O)cc1[N+](=O)[O-]",
        "output": "503"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.Cc1ccc(C(=O)Cl)cc1.Cc1ccccc1.OC1CCN(Cc2cccc(F)c2)CC1>>Cc1ccc(C(=O)OC2CCN(Cc3cccc(F)c3)CC2)cc1",
        "output": "51"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CC1CCC(c2ccc(O)cc2)CC1.CI.CN(C)C=O.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)CC1CCC(c2ccc(OC)cc2)CC1",
        "output": "62"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.N[C@@H]1CCN(Cc2ccccc2)C1.O=Cc1ccccc1.[Na+]>>c1ccc(CN[C@@H]2CCN(Cc3ccccc3)C2)cc1",
        "output": "468"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)C(C)(Oc1cccc([N+](=O)[O-])c1)C(=O)OCC.COC(=O)c1cc(COc2ccc([N+](=O)[O-])cc2)co1>>COC(=O)c1cc(COc2ccc(N)cc2)co1",
        "output": "202"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O.O=C(O)C(F)(F)F.O=C1CCNCC1OCc1ccccc1.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(=O)C(OCc2ccccc2)C1",
        "output": "694"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)C1(C)CCC(OCOCC[Si](C)(C)C)CC1.Cl.O.[Na+].[OH-]>>CC1(C(=O)O)CCC(OCOCC[Si](C)(C)C)CC1",
        "output": "361"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1CC(CN)CCN1.CN(C)c1ccncc1.ClCCl>>CC1CC(CNC(=O)OC(C)(C)C)CCN1",
        "output": "631"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ncc(CO)cc2C(F)(F)F)CC1.O=C(O)C(F)(F)F>>OCc1cnc(N2CCNCC2)c(C(F)(F)F)c1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.N#Cc1cccc([N+](=O)[O-])c1NCCO.[H][H].[Pd]>>N#Cc1cccc(N)c1NCCO",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1c(C[C@@H]2CCCCN2C(=O)OC(C)(C)C)nc2c(F)cccn12.ClCCl.O=C(O)C(F)(F)F>>Cc1c(C[C@@H]2CCCCN2)nc2c(F)cccn12",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OCCn1ccc(=O)c(O)c1Cc1ccccc1.CCO.Cl.[Na+].[OH-]>>O=c1ccn(CCO)c(Cc2ccccc2)c1O",
        "output": "225"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CC[C@@H]1COc2cc([N+](=O)[O-])ccc2N1CC(F)(F)F.[Pd]>>CC[C@@H]1COc2cc(N)ccc2N1CC(F)(F)F",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C[Si](C)(C)CCOCn1cnc(Br)c1.O=C([O-])[O-].OB(O)c1ccc2ccccc2c1.[Na+].[Na+].c1ccccc1>>C[Si](C)(C)CCOCn1cnc(-c2ccc3ccccc3c2)c1",
        "output": "876"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)CBr.Oc1ccc(Br)cc1>>CCOC(=O)COc1ccc(Br)cc1",
        "output": "123"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Br.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.NCc1cnc(Cl)s1.Nc1ncccc1C(=O)O.O.On1nnc2ccccc21>>Nc1ncccc1C(=O)NCc1cnc(Cl)s1",
        "output": "674"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)COC(=O)Cl.CCN(CC)CC.CCOc1cc(N)c(Cl)cc1C(=O)O.ClCCl.NCC1CN(Cc2ccc(F)cc2)CCO1>>CCOc1cc(N)c(Cl)cc1C(=O)NCC1CN(Cc2ccc(F)cc2)CCO1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(N)CC2)c2ccc(Cl)c(Cl)c2)CC1.O=C(Cl)c1ccc(F)cc1>>CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(NC(=O)c3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1",
        "output": "271"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)C1CCN(C(=O)C(=O)N2CCN(c3ccccc3C(C)(C)C)CC2)CC1.Cl.[Li+].[OH-]>>CC(C)(C)c1ccccc1N1CCN(C(=O)C(=O)N2CCC(C(=O)O)CC2)CC1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CCCC1=O.CS(=O)(=O)OCC1(C(F)(F)F)CC1.CS(=O)(=O)c1ccc(-c2cc3cc(C4CCNCC4)oc3cn2)c(F)c1.O.O=C([O-])[O-].[K+].[K+]>>CS(=O)(=O)c1ccc(-c2cc3cc(C4CCN(CC5(C(F)(F)F)CC5)CC4)oc3cn2)c(F)c1",
        "output": "496"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CC(O)c1ccc(Cc2cc3c(=O)n([C@H]4CCCC[C@@H]4O)cnc3c3ccncc23)cc1.CO.[Pd]>>CCC(O)c1ccc(Cc2cc3c(=O)n([C@H]4CCCC[C@@H]4O)cnc3c3ccncc23)cc1",
        "output": "116"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](N)C1.O=C(O)c1c[nH]c2c(-c3c(OCC4CC4)ccc4c3OCO4)ncnc12>>CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)c2c[nH]c3c(-c4c(OCC5CC5)ccc5c4OCO5)ncnc23)C1",
        "output": "737"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)C(C)(C)C(NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(C3CC3)nc12)C1CC1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)C(C)(C)C(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C1CC1",
        "output": "981"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc2nccc(Cl)c2cc1OC.COc1cccc2c(O)cccc12>>COc1cc2nccc(Oc3cccc4c(OC)cccc34)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccccc1.N#Cc1ccc(F)c2ccccc12.OC1CCNC1>>N#Cc1ccc(N2CCC(O)C2)c2ccccc12",
        "output": "26"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.CO.COc1ccc(C[C@H](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)O)c(OC)c1.O.O=C([O-])[O-].[K+].[K+].c1c[nH]cn1>>COc1ccc(C[C@H](C[C@H](O[Si](C)(C)C(C)(C)C)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)O)c(OC)c1",
        "output": "193"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)C[C@H](NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12)C(=O)O.CCN(CC)CC.CN(C)C=O.COC(=O)C(O)[C@@H](N)CC(C)C.Cl.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1>>COC(=O)C(O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCC.CCOC(C)=O.Fc1ccc(-c2cc(N3CCNCC3)ncn2)cc1.O=C(Nc1cccnc1)OCC(Cl)(Cl)Cl>>O=C(Nc1cccnc1)N1CCN(c2cc(-c3ccc(F)cc3)ncn2)CC1",
        "output": "980"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(O)CN.O=C(O)c1ccc(SCc2c(O[C@H](Cn3ccnc3)c3ccccc3)ccc3c2CCCC3=O)cc1>>CC(O)CNC(=O)c1ccc(SCc2c(O[C@H](Cn3ccnc3)c3ccccc3)ccc3c2CCCC3=O)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1c(C)nc(N2CCN(C)CC2)c2nccnc12.[Na+].[OH-]>>Cc1nc(N2CCN(C)CC2)c2nccnc2c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CNc1cccc(F)c1NC(=O)OC(C)(C)C.Cl.ClCCl>>CNc1cccc(F)c1N",
        "output": "782"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.COc1cc(N2CCNCC2)ccc1[N+](=O)[O-].ClCCl>>COc1cc(N2CCN(C(C)=O)CC2)ccc1[N+](=O)[O-]",
        "output": "369"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.COCC(=O)Cl.CS(C)=O.O=C(NCC(F)(F)F)Nc1cccc(-c2cnc3cc(-c4ccc(N5CCNCC5)nc4)cnn23)c1>>COCC(=O)N1CCN(c2ccc(-c3cnn4c(-c5cccc(NC(=O)NCC(F)(F)F)c5)cnc4c3)cn2)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cccc(-c2sc(C)nc2C(=O)O)c1.O=C(NC[C@H]1NC[C@H]2C[C@H]21)c1ccccn1>>Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@H]3C[C@H]3[C@H]2CNC(=O)c2ccccn2)c1",
        "output": "747"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.COCCN.COc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc2cc(C3=NCC(CC(=O)O)S3)[nH]c12.Cl.O.On1nnc2ccccc21>>COCCNC(=O)CC1CN=C(c2cc3cc(Oc4ccc(S(C)(=O)=O)nc4)cc(OC)c3[nH]2)S1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1noc(-c2ccc(Br)cc2)c1CO.O=C=NC1CCCC1>>Cc1noc(-c2ccc(Br)cc2)c1COC(=O)NC1CCCC1",
        "output": "235"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)OC(=O)NC(CN)Cc1ccccc1.O=C(O)c1ccc(Cl)cc1.O=C(n1ccnc1)n1ccnc1>>CC(C)OC(=O)NC(CNC(=O)c1ccc(Cl)cc1)Cc1ccccc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc2c(c1)C(c1ccccc1)=NC(NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(=O)OC(C)(C)C)C(=O)N2.ClCCl.O=C(O)C(F)(F)F>>COc1ccc2c(c1)C(c1ccccc1)=NC(NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(=O)O)C(=O)N2",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N(CCCOCCO)CCc1cccc(Cl)c1.CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCCOCCCN(CCc2cccc(Cl)c2)C(=O)OC(C)(C)C)cc1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(=O)O.NCCN1CCOCC1>>CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(=O)NCCN1CCOCC1",
        "output": "697"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N(Cc1cc2c(nn1)OCCO2)C1CCNCC1.CO.ClC(Cl)Cl.O=CC1CCN2C(=O)COc3ccc(F)c1c32>>CC(C)(C)OC(=O)N(Cc1cc2c(nn1)OCCO2)C1CCN(CC2CCN3C(=O)COc4ccc(F)c2c43)CC1",
        "output": "484"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(-c3cc(N)cc(F)c3)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12.NS(=O)(=O)Cl.c1ccncc1>>Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(-c3cc(F)cc(NS(N)(=O)=O)c3)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12",
        "output": "395"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)C(=O)Cl.CCN(CC)CC.CCOC(=O)Cc1ccc(N)cc1.Cl.O=C(O)C(Cc1ccccc1)NS(=O)(=O)c1ccc(Br)cc1>>CCOC(=O)Cc1ccc(NC(=O)C(Cc2ccccc2)NS(=O)(=O)c2ccc(Br)cc2)cc1",
        "output": "365"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1CCN([C@@H]2CC[C@@H](n3cc(-c4ccc(CN)cc4)c4c(N)ncnc43)CC2)CC1.ClCCl.O=C(Cl)c1ccccc1.c1ccncc1>>CN1CCN([C@@H]2CC[C@@H](n3cc(-c4ccc(CNC(=O)c5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1",
        "output": "411"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.CC(=O)O.COc1ccc([N+](=O)[O-])c(C(F)(F)F)n1>>O=[N+]([O-])c1ccc(O)nc1C(F)(F)F",
        "output": "408"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Cc1ccccc1.CCOC(C)=O.CO.NCCC(=O)O.[BH3-]C#N.[Na+]>>CC(Cc1ccccc1)NCCC(=O)O",
        "output": "236"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)COc1ccccc1Oc1cc(Oc2cc(F)c(C(F)(F)F)c(Cl)c2)ccc1[N+](=O)[O-].[Na+].[OH-]>>O=C(O)COc1ccccc1Oc1cc(Oc2cc(F)c(C(F)(F)F)c(Cl)c2)ccc1[N+](=O)[O-]",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOCC.C[C@H]1CN(C(=O)OCc2ccccc2)C[C@@H](NC(=O)OC(C)(C)C)C1=O.C[Mg]Br>>C[C@H]1CN(C(=O)OCc2ccccc2)C[C@@H](NC(=O)OC(C)(C)C)C1(C)O",
        "output": "514"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=C(O)c1ccc(F)c(Br)c1.O=S(=O)(O)O>>COC(=O)c1ccc(F)c(Br)c1",
        "output": "33"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.O.O=C(Nc1ccc2c(c1)S(=O)(=O)C=C2)OCC(Cl)(Cl)Cl.c1csc(-c2nsc(N3CCNCC3)n2)c1>>O=C(Nc1ccc2c(c1)S(=O)(=O)C=C2)N1CCN(c2nc(-c3cccs3)ns2)CC1",
        "output": "980"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)Cn1c(C)c(Cc2cccnc2S(=O)(=O)c2ccc(F)cc2)c2c1CC(C)(C)CC2=O.O.[Na+].[OH-]>>Cc1c(Cc2cccnc2S(=O)(=O)c2ccc(F)cc2)c2c(n1CC(=O)O)CC(C)(C)CC2=O",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(C)=O.O.O=[N+]([O-])c1cc(Br)cc([N+](=O)[O-])c1>>Nc1cc(Br)cc([N+](=O)[O-])c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cccc(F)c1C(C)(C)CC(O)(C=O)C(F)(F)F.Cc1ncc2c(N)ccc(F)c2n1>>COc1cccc(F)c1C(C)(C)CC(O)(CNc1ccc(F)c2nc(C)ncc12)C(F)(F)F",
        "output": "336"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cc1ccc(S(=O)(=O)Cl)cc1.O[C@H]1CCOC1.c1ccncc1>>Cc1ccc(S(=O)(=O)O[C@H]2CCOC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(CCO)CCc2cc(Cl)ccc2O1.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.c1ccncc1>>Cc1ccc(S(=O)(=O)OCCC2(C)CCc3cc(Cl)ccc3O2)cc1",
        "output": "197"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.N#Cc1cccnc1N[C@@H]1CCNC1.O=Cc1ccc(F)c(C(=O)O)c1>>N#Cc1cccnc1N[C@@H]1CCN(C(=O)c2cc(C=O)ccc2F)C1",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=O.CC#N.CCN(CC)CC.CCOCC.CCc1ccccc1O.Cl.[Cl-].[Cl-].[Mg+2]>>CCc1cccc(C=O)c1O",
        "output": "451"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cc1ccc(S(=O)(=O)O)cc1.O=C(O)CC1NC(=O)c2ccccc21>>COC(=O)CC1NC(=O)c2ccccc21",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)[C@@H]1C[C@@H](NC(=O)OCc2ccccc2)C1.NN.O>>NNC(=O)[C@@H]1C[C@@H](NC(=O)OCc2ccccc2)C1",
        "output": "130"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CO.Cc1ccc(C(=O)Nc2ccc(C(O)CCc3ccccn3)cc2)c(N2CCC(C)CC2)n1.Cl.[H][H].[Pd]>>Cc1ccc(C(=O)Nc2ccc(CCCc3ccccn3)cc2)c(N2CCC(C)CC2)n1",
        "output": "447"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(Cc2ccccc2O)ccc2cc(O)ccc12.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Oc1ccc2c(C(O)c3ccc(OCCN4CCCCC4)cc3)c(Cc3ccccc3O)ccc2c1",
        "output": "157"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)c1ccc(OC[C@@H]2CC[C@H](c3ccccc3)N2)cc1.COc1cc(CC(=O)O)ccc1NC(=O)Nc1ccccc1Br.Cl.O>>COC(=O)c1ccc(OC[C@@H]2CC[C@H](c3ccccc3)N2C(=O)Cc2ccc(NC(=O)Nc3ccccc3Br)c(OC)c2)cc1",
        "output": "633"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.Cc1cc2ncoc2cc1-c1ccc(N)nc1.ClCCl.ClCCl.O=C(Cl)c1ccccc1F.O=C([O-])O.[Na+]>>Cc1cc2ncoc2cc1-c1ccc(NC(=O)c2ccccc2F)nc1",
        "output": "463"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.CCOC(=O)C(C)(C)Oc1ccc(O)cc1C.Cn1nc(-c2ccc(OC(F)(F)F)cc2)cc1CCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)C(C)(C)Oc1ccc(OCCc2cc(-c3ccc(OC(F)(F)F)cc3)nn2C)cc1C",
        "output": "478"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(O)C(F)(F)F.O=C1CCC(=O)N1I.O=C1O[C@@H](CO)CN1c1cccc(F)c1>>O=C1O[C@@H](CO)CN1c1ccc(I)c(F)c1",
        "output": "834"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#CC[C@@H](C[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C.C1CCOC1.CCN(C(C)C)C(C)C.[Cu]I.[N-]=[N+]=NCCO>>CC(C)(C)OC(=O)N[C@@H](C[C@H](Cc1cn(CCO)nn1)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C",
        "output": "963"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)[C@@H]1CC[C@@H](c2nnc(-c3ccc(-c4cnc(N5CCN(CC6CCCC6)CC5)nc4)cc3)s2)CC1.ClC(Cl)Cl.O.[Al+3].[F-].[H-].[H-].[H-].[H-].[Li+].[Na+]>>OC[C@@H]1CC[C@@H](c2nnc(-c3ccc(-c4cnc(N5CCN(CC6CCCC6)CC5)nc4)cc3)s2)CC1",
        "output": "343"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC1(C(N)=O)CCN(Cc2ccccc2)CC1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC1(CN)CCN(Cc2ccccc2)CC1",
        "output": "112"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1cc(Br)ccc1-n1cnc(C)c1.ClCCl.ClCCl.Nc1nc2c(Cl)cc(C(F)(F)F)cn2n1>>COc1cc(Nc2nc3c(Cl)cc(C(F)(F)F)cn3n2)ccc1-n1cnc(C)c1",
        "output": "970"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COc1ccc(Br)c(C(=O)O)c1.O=S(=O)(O)O>>CCOC(=O)c1cc(OC)ccc1Br",
        "output": "33"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cc1cc(C(=O)O)cc(Cl)n1.Cl.Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1.On1nnc2ccccc21.[Cl-].[NH4+]>>Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)cc(Cl)n1",
        "output": "50"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COC(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3C2=O)cc1.NN.O>>COC(=O)c1ccccc1-c1ccc(CN)cc1",
        "output": "418"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CO.COC(=O)C(NCc1cccc(C(F)(F)F)c1)c1cn(Cc2ccccc2)c2ccccc12.C[O-].Cl.[Na+]>>CCOC(=O)C(NCc1cccc(C(F)(F)F)c1)c1cn(Cc2ccccc2)c2ccccc12",
        "output": "289"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCCCCC.CCOC(=O)CCc1cn(-c2ccc(Cl)cn2)nc1C(C)C.Cl.[H-]>>CC(C)c1nn(-c2ccc(Cl)cn2)cc1CCCO",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1ccc2c(c1)CN(C(=O)OC(C)(C)C)C2.Cl.[Na+].[OH-]>>CC(C)(C)OC(=O)N1Cc2ccc(C(=O)O)cc2C1",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCO.Cn1c(=O)c([N+](=O)[O-])c(N)c2cccnc21.[Pd]>>Cn1c(=O)c(N)c(N)c2cccnc21",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCCc2c(sc3ccc(Br)cc23)C1.O=c1cc(OCc2ccccc2)cc[nH]1>>CC(C)(C)OC(=O)N1CCCc2c(sc3ccc(-n4ccc(OCc5ccccc5)cc4=O)cc23)C1",
        "output": "349"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)COc1ccc(Cl)cc1CCl.CCOCC.CS(C)=O.O.[C-]#N.[Na+]>>CC(C)COc1ccc(Cl)cc1CC#N",
        "output": "38"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCC(Br)C(=O)OCC.Oc1ccc(C2=CCCCCC2)cc1>>CCCCCC(Oc1ccc(C2=CCCCCC2)cc1)C(=O)OCC",
        "output": "455"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CNc1ncc(Br)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)F)c3c2C(F)(F)CCC3(F)F)n1.COCCOCCN.CS(=O)(=O)c1ncc(Br)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)F)c3c2C(F)(F)CCC3(F)F)n1>>COCCOCCNc1ncc(Br)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)F)c3c2C(F)(F)CCC3(F)F)n1",
        "output": "629"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOP(=O)(COCCOC(C)=O)OCC.Cl>>CCOP(=O)(COCCO)OCC",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCC(O)c1cc(C(=O)O)ccc1C1CC1.ClCCCl>>CCC(=O)c1cc(C(=O)O)ccc1C1CC1",
        "output": "32"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1ncc2cc(C(=O)Nc3cc(C(=O)O)ccc3Cl)c(=O)[nH]c2n1.F[P-](F)(F)(F)(F)F.NCc1ccc(Cl)cc1>>COc1ncc2cc(C(=O)Nc3cc(C(=O)NCc4ccc(Cl)cc4)ccc3Cl)c(=O)[nH]c2n1",
        "output": "753"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)NC[C@@H]1OC(=O)N2c3ccccc3C[C@@H]12.CC(=O)O.O=[N+]([O-])O>>CC(=O)NC[C@@H]1OC(=O)N2c3ccc([N+](=O)[O-])cc3C[C@@H]12",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCC.CCCC[C@@H](NC(=O)OC(C)(C)C)C(=O)O.CCOCC.COC(=O)CN.Cl>>CCCC[C@@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)OC",
        "output": "129"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)C(=N)NO.CCc1ccc(C2CC(C(=O)O)CN(C(=O)N(C)CC)C2)cc1>>CCc1ccc(C2CC(c3nc(C(C)(C)C)no3)CN(C(=O)N(C)CC)C2)cc1",
        "output": "924"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)Cn1c(=O)c(=O)[nH]c2cc(-n3c(C)ccc3C)c(Cl)cc21.O.[Li+].[OH-]>>Cc1ccc(C)n1-c1cc2[nH]c(=O)c(=O)n(CC(=O)O)c2cc1Cl",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "NC(=O)c1ccc(Oc2ccc(C=O)cc2Cl)cn1.NCCc1cccnc1>>NC(=O)c1ccc(Oc2ccc(CNCCc3cccnc3)cc2Cl)cn1",
        "output": "468"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1cc(C#N)ccc1N.O.[Li+].[OH-]>>N#Cc1ccc(N)c(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)c1c(OCc2ccccc2)c2ncccc2n(Cc2ccccc2)c1=O.Cl.O.[Na+].[OH-]>>O=C(O)c1c(OCc2ccccc2)c2ncccc2n(Cc2ccccc2)c1=O",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CNC.CNCC1(c2ccc(F)c(Cl)c2)CCCCC1.O=CC1(c2ccc(F)c(Cl)c2)CCCCC1>>CN(C)CC1(c2ccc(F)c(Cl)c2)CCCCC1",
        "output": "484"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOC(=O)c1cn([C@H](CO)C(C)(C)C)c2cc(OC)c(OCc3ccc(OC)cc3)cc2c1=O.CN(C)C=O.c1c[nH]cn1>>CCOC(=O)c1cn([C@H](CO[Si](C)(C)C(C)(C)C)C(C)(C)C)c2cc(OC)c(OCc3ccc(OC)cc3)cc2c1=O",
        "output": "193"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COB(OC)OC.COc1cc(Br)cc(OC)c1.[Li]CCCC>>COc1cc(OC)cc(B(O)O)c1",
        "output": "789"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.NO.O=C1CCc2cc(-c3ccc(C(F)(F)F)cc3)ccc2C1.c1ccncc1>>ON=C1CCc2cc(-c3ccc(C(F)(F)F)cc3)ccc2C1",
        "output": "86"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)n1cc(C(=O)c2cncc(N)c2)c2cncnc21.O=C(O)C(CO)c1ccccc1>>CC(C)n1cc(C(=O)c2cncc(NC(=O)C(CO)c3ccccc3)c2)c2cncnc21",
        "output": "724"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.Nc1ccc(Cl)c(NC(=O)Nc2ccccc2)c1.O=S(=O)(Cl)c1cccc(-c2ccc(F)cc2)c1>>O=C(Nc1ccccc1)Nc1cc(NS(=O)(=O)c2cccc(-c3ccc(F)cc3)c2)ccc1Cl",
        "output": "68"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1C2CCC1CN(c1cc(N3CCN(S(C)(=O)=O)CC3)ccn1)C2.CO.Cl>>CS(=O)(=O)N1CCN(c2ccnc(N3CC4CCC(C3)N4)c2)CC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COc1ccc(-c2ccc3[nH]c4ncc(-c5cccc([N+](=O)[O-])c5)cc4c3c2)cc1.[Pd]>>COc1ccc(-c2ccc3[nH]c4ncc(-c5cccc(N)c5)cc4c3c2)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1ccc(-c2nc(-c3ccc4c(c3)CCC(=O)N4)cs2)cc1.[K+].[OH-]>>O=C1CCc2cc(-c3csc(-c4ccc(C(=O)O)cc4)n3)ccc2N1",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1ccc(N=C=O)cc1.COc1cc(N)cc(OC)c1OC.Cc1ccccc1>>COc1cc(NC(=O)Nc2ccc(C(C)=O)cc2)cc(OC)c1OC",
        "output": "804"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=COCCCl.CC(=O)O.CCC(C)=O.Cc1ccc(-c2ccccc2)c([IH2]=O)c1S(=O)(=O)[O-].ClCCl.Cl[Ti](Cl)(Cl)Cl.O=S(=O)([N-]S(=O)(=O)C(F)(F)F)C(F)(F)F.[Na+].[Na+].[O-]c1ccccc1>>C=COCCOc1ccccc1",
        "output": "74"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.NN.O.O=[N+]([O-])c1ccc(Cl)nc1>>NNc1ccc([N+](=O)[O-])cn1",
        "output": "417"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CC(Cc1ccc(-c2ccccn2)cc1)NC(=O)OCc1ccccc1.CCOC(C)=O.CO.Cl.[OH-].[OH-].[Pd+2]>>CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CC(N)Cc1ccc(-c2ccccn2)cc1",
        "output": "574"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H]1CNC[C@H]1c1ccccc1.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.COCC1CCC(C(=O)O)CC1.F[P-](F)(F)(F)(F)F>>COCC1CCC(C(=O)N2C[C@@H](c3ccccc3)[C@H](N(C)C(=O)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CN1C(=O)c2ccccc2C1=O.CC#N.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.Nc1cc(Br)cc(C(F)(F)F)c1.[Pd+2]>>Nc1cc(/C=C/N2C(=O)c3ccccc3C2=O)cc(C(F)(F)F)c1",
        "output": "539"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)C(CC1CCCC1)c1ccc(S(=O)(=O)C(F)(F)F)cc1.[Li+].[OH-]>>O=C(O)C(CC1CCCC1)c1ccc(S(=O)(=O)C(F)(F)F)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=[N+]([O-])c1ccccc1NCCN1CCC(Cc2nc3ccccc3n2Cc2ccc(F)cc2)CC1.[H][H].[Pd].c1ccsc1>>Nc1ccccc1NCCN1CCC(Cc2nc3ccccc3n2Cc2ccc(F)cc2)CC1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=O)Cl.CCN(CC)CC.ClCCl.O=C(OCc1ccccc1)N1CCC(Nc2ccc(F)c(F)c2)CC1>>CCC(=O)N(c1ccc(F)c(F)c1)C1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "160"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CN(C)C=O.N#Cc1ccnc(N)c1.O=C1CCC(=O)N1Br>>N#Cc1cc(N)ncc1Br",
        "output": "518"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COc1nc(CCCCCCCCCOC2CCCCO2)c(C)c(OCc2ccccc2)c1OC.Cc1ccc(S(=O)(=O)O)cc1>>COc1nc(CCCCCCCCCO)c(C)c(OCc2ccccc2)c1OC",
        "output": "543"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](CCN2CCC(C(=O)c3ccc(Cl)cc3Cl)CC2)CC1.O=C(O)C(F)(F)F>>N[C@H]1CC[C@H](CCN2CCC(C(=O)c3ccc(Cl)cc3Cl)CC2)CC1",
        "output": "538"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCC2=NCCCN2CC1.CC(C)S(=O)(=O)Cl.ClCCl.Nc1ccccc1-c1ccc(Br)cc1>>CC(C)S(=O)(=O)Nc1ccccc1-c1ccc(Br)cc1",
        "output": "194"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c1c[nH]c(-c2cc(Oc3ccc(NC(=O)Nc4cccc(C)c4)c(F)c3)ccn2)c1.Cl.O.[Na+].[OH-]>>Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(-c4cc(C(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(=O)O)c[nH]4)c3)cc2F)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.ClCCl.Nc1ccccc1.O=C(O)[C@@H]1CCc2ncc(N(Cc3cccc(C(F)(F)F)c3)C(=O)OCc3ccccc3)c(=O)n21.O=C([O-])O.On1nnc2cccnc21.[Na+]>>O=C(Nc1ccccc1)[C@@H]1CCc2ncc(N(Cc3cccc(C(F)(F)F)c3)C(=O)OCc3ccccc3)c(=O)n21",
        "output": "563"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cccc(Oc2ccccc2C2OCCO2)c1.Cl.O>>COc1cccc(Oc2ccccc2C=O)c1",
        "output": "655"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COc1cc(Cl)ccc1[N+](=O)[O-].Cl.O.O=C([O-])O.O=S([O-])S(=O)[O-].[K+].[Na+].[Na+]>>COc1cc(Cl)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CSCCN1.Cc1oc(-c2ccccc2)nc1CCNC(=O)c1c(C(=O)O)cnn1C>>Cc1oc(-c2ccccc2)nc1CCNC(=O)c1c(C(=O)N2CCSCC2)cnn1C",
        "output": "733"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)c1ccc(-n2cc(CO)nc2-c2ccc(Cl)cc2)cc1.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CS(=O)(=O)c1ccc(-n2cc(C=O)nc2-c2ccc(Cl)cc2)cc1",
        "output": "287"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COC(=O)Cc1ccc(Br)s1.Cc1ccccc1.N#N.O=C([O-])[O-].O=[N+]([O-])c1cccc(B(O)O)c1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)Cc1ccc(-c2cccc([N+](=O)[O-])c2)s1",
        "output": "864"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CC(=O)Cl.CCN(C(C)C)C(C)C.COCCN.ClCCl>>C=CC(=O)NCCOC",
        "output": "298"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(B(O)O)cc1Cl.CS(=O)(=O)c1ccc(-c2cc(F)c(F)cc2Br)cc1>>COc1ccc(-c2cc(F)c(F)cc2-c2ccc(S(C)(=O)=O)cc2)cc1Cl",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Brc1ccccn1.C#CCCc1nc2c(C(F)(F)F)ccc(F)c2o1>>Fc1ccc(C(F)(F)F)c2nc(CCC#Cc3ccccn3)oc12",
        "output": "777"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1cc(CCCc2ccccc2F)on1.O.[K+].[OH-]>>O=C(O)c1cc(CCCc2ccccc2F)on1",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)Cl.CCC(=S)NC1C(=O)N2C(C(=O)O)=C(CSc3nnc(CN)s3)CS[C@H]12.CCN(CC)CC.O>>CCC(=S)NC1C(=O)N2C(C(=O)O)=C(CSc3nnc(CNC(C)=O)s3)CS[C@H]12",
        "output": "45"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)O.CC(C)(C)[O-].CCn1c(=O)c(CCCO)c(-c2cccc(Cl)c2)c2ccc(C)nc21.CI.Cl.O.[Na+]>>CCn1c(=O)c(CCCOC)c(-c2cccc(Cl)c2)c2ccc(C)nc21",
        "output": "140"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C#N)N1CCC(C(=O)c2ccc(F)cc2)CC1.CO.N.[H][H].[Ni]>>CC(CN)N1CCC(C(=O)c2ccc(F)cc2)CC1",
        "output": "246"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CCCN)C(=O)O.CN(C)C=O.O=C1OC(=O)c2ccccc21>>CC(C)(C)OC(=O)N[C@@H](CCCN1C(=O)c2ccccc2C1=O)C(=O)O",
        "output": "341"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCNCC.N#Cc1ccc(Oc2cc(Oc3ccc(C#N)cc3)cc(C(=O)O)c2)cc1>>CCN(CC)C(=O)c1cc(Oc2ccc(C#N)cc2)cc(Oc2ccc(C#N)cc2)c1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Nc1cc(Cl)ncn1.O=[N+]([O-])c1ccc(O)c(Cl)c1>>Nc1cc(Oc2ccc([N+](=O)[O-])cc2Cl)ncn1",
        "output": "668"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.C[Si](C)(C)CCOCn1nc(-c2ccc(-c3ccc(C(F)(F)F)cc3)cc2)c2c1-c1ccsc1C2.Cl>>FC(F)(F)c1ccc(-c2ccc(-c3n[nH]c4c3Cc3sccc3-4)cc2)cc1",
        "output": "813"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCS(=O)(=O)Nc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Br.CCc1ccc(C)nc1.[C-]#N.[Cl-].[Cl-].[H-].[Na+].[Na+].[Pd+2].[Zn+2]>>CCS(=O)(=O)Nc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1C#N",
        "output": "65"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NCC1(C(=O)O)C=CC2=C(CCCC2)C1.CCO.COC(=O)c1ccc2c(c1)C(CNC(=O)OC(C)(C)C)CCC2.O.[Na+].[OH-]>>CC(C)(C)OC(=O)NCC1CCCc2ccc(C(=O)O)cc21",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CCc1cccc(N)c1.CCOC(C)=O.O=C(O)c1ccc(-c2ccc(Cl)cc2)o1>>CCOC(=O)CCc1cccc(NC(=O)c2ccc(-c3ccc(Cl)cc3)o2)c1",
        "output": "860"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)Cl.CC(C)(C)CC1CN(C(=O)NCC2CCNCC2)C(c2cccc(Cl)c2F)C12C(=O)Nc1cc(Cl)ccc12.CCN(CC)CC.O=C(O)C(F)(F)F>>CC(=O)N1CCC(CNC(=O)N2CC(CC(C)(C)C)C3(C(=O)Nc4cc(Cl)ccc43)C2c2cccc(Cl)c2F)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCNC.O=C(O)CCCCCCCBr>>CCCCN(C)C(=O)CCCCCCCBr",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCNc1nc(OC)c(C(=O)OC)nc1Cl.Cl.O.[Na+].[OH-]>>CCNc1nc(OC)c(C(=O)O)nc1Cl",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.COc1ccc2c(=O)ccn(CCN3CCC(N)CC3)c2c1.ClC(Cl)Cl.O=Cc1cc2c(cn1)OCCO2.[Na+]>>COc1ccc2c(=O)ccn(CCN3CCC(NCc4cc5c(cn4)OCCO5)CC3)c2c1",
        "output": "775"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.COC(=O)[C@@H](C)Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc4ccccn4)c3)c12>>C[C@@H](Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc4ccccn4)c3)c12)C(=O)N1CCCC1",
        "output": "227"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCC(C)C.CCN(C(C)C)C(C)C.CCOCC.N#Cc1ccc(Cl)cc1F.NC(CCO)c1ccccc1>>N#Cc1ccc(Cl)cc1NC(CCO)c1ccccc1",
        "output": "764"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CN(C)C1(Cc2ccccc2)CCC2(CCNC2)CC1.CO.ClCCl.O=C([O-])O.O=CC1CCCC1.[BH3-]C#N.[Na+].[Na+]>>CN(C)C1(Cc2ccccc2)CCC2(CCN(CC3CCCC3)C2)CC1",
        "output": "484"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)OC(C)C.CCO.N#Cc1cccc(F)c1F.NN.O>>Nc1n[nH]c2c(F)cccc12",
        "output": "945"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccccc1.Cc1c(C(=O)Cl)cccc1[N+](=O)[O-].ClCCl.O.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(C(=O)c2cccc([N+](=O)[O-])c2C)cc1",
        "output": "61"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)OCCCC1COc2ccc(F)cc21.Fc1ccc(C2CCNCC2)cc1>>Fc1ccc(C2CCN(CCCC3COc4ccc(F)cc43)CC2)cc1",
        "output": "496"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1ccc(-c2ccc(Cl)c(C(=O)O)c2)cn1.Cc1ccc(C2(CN)CCCCC2)cc1.Cl.O.On1nnc2ccccc21>>Cc1ccc(C2(CNC(=O)c3cc(-c4ccc(C)nc4)ccc3Cl)CCCCC2)cc1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CS(=O)(=O)Cl.Cl.FC(F)(F)c1cc(CO[C@H]2CCNC[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1>>CS(=O)(=O)N1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](C(c2ccccc2)c2ccccc2)C1",
        "output": "584"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC=CCCCCCC.CI.CN(CC(=O)O)C(=O)OC(C)(C)C.c1ccccc1>>COC(=O)CN(C)C(=O)OC(C)(C)C",
        "output": "415"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CC[C@H](N)CNc1ccc(C)cc1C.ClCCl.Nc1cc(Cl)cc(Cl)c1S(=O)(=O)Cl>>CC[C@@H](CNc1ccc(C)cc1C)NS(=O)(=O)c1c(N)cc(Cl)cc1Cl",
        "output": "43"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1cnc(SC)nc1C1CCCCC1.ClCCl.O=C(OO)c1cccc(Cl)c1>>COC(=O)c1cnc(S(C)=O)nc1C1CCCCC1",
        "output": "595"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3cccc(-c4nc5ccc(N)cc5o4)c3)cc12.CS(=O)(=O)Cl.ClCCl.c1ccncc1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3cccc(-c4nc5ccc(NS(C)(=O)=O)cc5o4)c3)cc12",
        "output": "194"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1ccc(CN2C(=O)C3(COc4cc5c(cc43)CCO5)c3ccccc32)o1.O.[Na+].[OH-]>>O=C(O)c1ccc(CN2C(=O)C3(COc4cc5c(cc43)CCO5)c3ccccc32)o1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.Cc1cccc(C#CC=C2CCNCC2)n1.ClC(Cl)Cl>>Cc1ccc(S(=O)(=O)N2CCC(=CC#Cc3cccc(C)n3)CC2)cc1",
        "output": "99"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCS(=O)(=O)Cl.COc1ccccc1C(=O)c1cnc(NC2CCNCC2)nc1N.O=C(O)C(F)(F)F>>CCCS(=O)(=O)N1CCC(Nc2ncc(C(=O)c3ccccc3OC)c(N)n2)CC1",
        "output": "584"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)CCCc1cn(CC(=O)OCC)c2c(C#C[Si](C)(C)C)cccc12.O.O=C([O-])[O-].[K+].[K+]>>C#Cc1cccc2c(CCCC(=O)OCC)cn(CC(=O)OCC)c12",
        "output": "337"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CNCc1cc2cc(F)ccc2n1C.O.O=C(O)/C=C/c1cnc2c(c1)CCC(=O)N2.On1nnc2ccccc21>>CN(Cc1cc2cc(F)ccc2n1C)C(=O)/C=C/c1cnc2c(c1)CCC(=O)N2",
        "output": "811"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CS(=O)(=O)Cl.O=S(=O)(NCCO)c1ccc(I)cc1>>CS(=O)(=O)OCCNS(=O)(=O)c1ccc(I)cc1",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[O-].CI.CN(C)C=O.COC1N=C(c2ccccc2Cl)c2cc(Cl)ccc2-c2c[nH]cc21.O.[K+]>>COC1N=C(c2ccccc2Cl)c2cc(Cl)ccc2-c2cn(C)cc21",
        "output": "191"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)NCCCCCCCCCCC(=O)Cl.CC(=O)NCCCCCCCCCCC(=O)O.CN(C)C=O.COc1ccccc1F.Cl.ClCCl.O.O=C(Cl)C(=O)Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(C(=O)CCCCCCCCCCNC(C)=O)cc1F",
        "output": "31"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.C1CCOC1.Cc1nc2c([nH]1)-c1ccccc1N(C(=O)c1ccccc1)CC2.[H-].[I-].[K+].[Na+]>>Cc1nc2c(n1Cc1ccccc1)-c1ccccc1N(C(=O)c1ccccc1)CC2",
        "output": "658"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)COC[C@@H]1CC(c2ccc(-c3ccc(N4C[C@H](Cn5ccnn5)OC4=O)cc3F)cn2)=NO1.CCOCC.O=C(O)C(F)(F)F>>O=C(O)COC[C@@H]1CC(c2ccc(-c3ccc(N4C[C@H](Cn5ccnn5)OC4=O)cc3F)cn2)=NO1",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1ccc(O)cc1.CN(C)C=O.O.O=C([O-])[O-].OCCCl.[K+].[K+]>>CC(=O)c1ccc(OCCO)cc1",
        "output": "74"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O=C(O)c1ccc(C(Cc2ccc(F)cc2)C(=O)Nc2nc3ccccc3o2)cc1.On1nnc2cccnc21.[Cl-].[NH4+]>>NC(=O)c1ccc(C(Cc2ccc(F)cc2)C(=O)Nc2nc3ccccc3o2)cc1",
        "output": "358"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCOCC1.COCC(=O)O.COc1cnc(N2CCOCC2)c2sc(N)nc12.F[P-](F)(F)(F)(F)F>>COCC(=O)Nc1nc2c(OC)cnc(N3CCOCC3)c2s1",
        "output": "681"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ncc(C(CN)N2CCOCC2)cn1.O=C(O)c1c(F)cccc1Cl>>Cc1ncc(C(CNC(=O)c2c(F)cccc2Cl)N2CCOCC2)cn1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Clc1cc(Cl)ncn1.O=C1C(=O)c2ccccc2C2=C1SCC1(CCNCC1)O2>>O=C1C(=O)c2ccccc2C2=C1SCC1(CCN(c3cc(Cl)ncn3)CC1)O2",
        "output": "162"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(N)c1ccccc1.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O=C(O)Cn1nc(-c2ccc(Cl)cc2)n(C2CC2)c1=O.On1nnc2ccccc21>>CC(C)(NC(=O)Cn1nc(-c2ccc(Cl)cc2)n(C2CC2)c1=O)c1ccccc1",
        "output": "599"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CN(c1cccc2cc(C3=NCC(CC=O)S3)[nH]c12)S(=O)(=O)c1cccs1.CO.NCCO.[BH4-].[Na+]>>CN(c1cccc2cc(C3=NCC(CCNCCO)S3)[nH]c12)S(=O)(=O)c1cccs1",
        "output": "426"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.ClCCl.NS(=O)(=O)N1CCOCC1.O=C(O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F>>O=C(NS(=O)(=O)N1CCOCC1)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F",
        "output": "886"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)[O-].COC(=O)CCc1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)c(F)c1.[Na+].[Na+].[OH-]>>O=C(O)CCc1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)c(F)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCc1nc2ccc(OC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCCCc1nc2ccc(OC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NC1CCNCC1.O=C(O)c1ccncc1Nc1ccc(I)cc1F>>CC(C)(C)OC(=O)NC1CCN(C(=O)c2ccncc2Nc2ccc(I)cc2F)CC1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CNc1ccc(Br)cc1[N+](=O)[O-].O=C(Cl)c1ccccc1.c1ccncc1>>CN(C(=O)c1ccccc1)c1ccc(Br)cc1[N+](=O)[O-]",
        "output": "614"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.Clc1cncc(Cl)n1.O=C1CCc2ccc(O)cc21>>O=C1CCc2ccc(Oc3cncc(Cl)n3)cc21",
        "output": "210"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COCCOCCO.COc1ccc(CNc2ncnc3cc(OC)c(O)cc23)cc1>>COCCOCCOc1cc2c(NCc3ccc(OC)cc3)ncnc2cc1OC",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(N)cc([N+](=O)[O-])c1.Cl.O.O=N[O-].[I-].[K+].[Na+]>>COc1cc(I)cc([N+](=O)[O-])c1",
        "output": "200"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=[N+]([O-])c1ccc(N2CCNCC2)cc1.OC(CCCl)COc1ccccc1>>O=[N+]([O-])c1ccc(N2CCN(CCC(O)COc3ccccc3)CC2)cc1",
        "output": "138"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(OCCN)nc2s1>>CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(OCCNC(=O)CNC(=O)OC(C)(C)C)nc2s1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1nc2c(C#N)cccn2c1-c1cccc(O)c1.O=S(=O)(CCCO)c1cccc(Br)c1>>CC(C)(C)c1nc2c(C#N)cccn2c1-c1cccc(Oc2cccc(S(=O)(=O)CCCO)c2)c1",
        "output": "238"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CO.ClC(Cl)Cl.NC1CC1.O=C([O-])O.O=Cc1ccncc1N1CCc2ccc(C(F)(F)F)cc2C1=O.[Na+]>>O=C1c2cc(C(F)(F)F)ccc2CCN1c1cnccc1CNC1CC1",
        "output": "468"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C(NCCOC1CCCCO1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1N(CCO)CCCl.O=C([O-])O.[Na+]>>CS(=O)(=O)OCCN(CCCl)c1c(C(=O)NCCOC2CCCCO2)cc([N+](=O)[O-])cc1[N+](=O)[O-]",
        "output": "0"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)N1CCC(COS(C)(=O)=O)CC1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(=S)N1CCC(COS(C)(=O)=O)CC1",
        "output": "695"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC(C)O.CC(CCCC1(C)COC(C)(C)O1)C1CCC2C(O)CCCC12C.ClCCl.O.O=[Cr](=O)([O-])Cl.O=[Cr](=O)([O-])Cl.[Na+].c1ccc(-c2cccc[nH+]2)[nH+]c1>>CC(CCCC1(C)COC(C)(C)O1)C1CCC2C(=O)CCCC21C",
        "output": "87"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCN(CC(=O)O)NC(=O)NCc1ccccc1.CCN(CC)CC.CCOC(CN(Cc1cccc(F)n1)C(=O)[C@@H](N)Cc1ccc(OC(C)(C)C)cc1)OCC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O>>C=CCN(CC(=O)N[C@@H](Cc1ccc(OC(C)(C)C)cc1)C(=O)N(Cc1cccc(F)n1)CC(OCC)OCC)NC(=O)NCc1ccccc1",
        "output": "133"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br.CC(=O)c1cccc(N)c1O.COc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>COc1ccc(S(=O)(=O)Nc2cccc(C(C)=O)c2O)cc1",
        "output": "68"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)n1c(C(=O)c2ccccc2)c(N)c2ccc(Cl)cc21.O=C(Cl)CCl>>CCOC(=O)n1c(C(=O)c2ccccc2)c(NC(=O)CCl)c2ccc(Cl)cc21",
        "output": "422"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCN1.Nc1ncc(Br)nc1Br>>Nc1ncc(Br)nc1N1CCOCC1",
        "output": "211"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C[S-].O=c1c2cc(-c3ccccc3)cnc2ccc2cccc(Br)c12.[Cu]Br.[Na+]>>CSc1cccc2ccc3ncc(-c4ccccc4)cc3c(=O)c12",
        "output": "824"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCCCCC.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CC[C@@H](N)CO.Cl.Cl.O.O=C(O)c1ccc(OCc2c(-c3ccc(F)c(F)c3)noc2CO)nc1.Oc1cccc2[nH]nnc12>>CC[C@H](CO)NC(=O)c1ccc(OCc2c(-c3ccc(F)c(F)c3)noc2CO)nc1",
        "output": "674"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CCc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)c2ccc(Cl)cc2)c1.CO.[Li+].[OH-]>>CC(C)(C)c1cc(NC(=O)c2ccc(Cl)cc2)n(-c2cccc(CCC(=O)O)c2)n1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "NC(=NO)c1ccccc1F.O=C(O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)N2CCC(O)CC2)C1>>O=C(N1CCC(O)CC1)N1CC(c2ccc(OC(F)(F)F)cc2)CC(c2nc(-c3ccccc3F)no2)C1",
        "output": "926"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C[C@@H]1C(=O)N(c2ccc[n+]([O-])c2)c2cnc(Cl)nc2N1C1CCCCC1.Nc1cc(F)c2[nH]ncc2c1.O=C(O)C(F)(F)F.OCC(F)(F)F>>C[C@@H]1C(=O)N(c2ccc[n+]([O-])c2)c2cnc(Nc3cc(F)c4[nH]ncc4c3)nc2N1C1CCCCC1",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1ccc(C2(N)CC2)cc1.Cl.O=C(O)c1cc(C(F)(F)F)cnc1N1CC(Oc2ccc(F)cc2)C1>>COC(=O)c1ccc(C2(NC(=O)c3cc(C(F)(F)F)cnc3N3CC(Oc4ccc(F)cc4)C3)CC2)cc1",
        "output": "790"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(C)O.COC(=O)C(C)(CCc1ccc(C#CC#C[C@@H]2C[C@H]2CO)cc1)S(C)(=O)=O.NO>>CC(CCc1ccc(C#CC#C[C@@H]2C[C@H]2CO)cc1)(C(=O)NO)S(C)(=O)=O",
        "output": "376"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCS(=O)(=O)CCCn1c(CO)cc2cc(Cl)ccc21.CS(=O)(=O)Cl.ClCCl>>CCS(=O)(=O)CCCn1c(COS(C)(=O)=O)cc2cc(Cl)ccc21",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN(C)C=O.O.O=Cc1cccc2[nH]ccc12.O=S(=O)(Cl)c1ccccc1.[H-].[Na+]>>O=Cc1cccc2c1ccn2S(=O)(=O)c1ccccc1",
        "output": "648"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)c1nc2c(C(F)(F)F)cc(I)cn2c1Br.Cl.O.[Na+].[OH-]>>O=C(O)c1nc2c(C(F)(F)F)cc(I)cn2c1Br",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.CCOCC.ClCCl.O=P1(c2ccc(F)cc2)c2ccccc2CN1c1ccccc1>>O=P1(c2ccc(F)cc2)c2ccccc2CN1c1ccc(Br)cc1",
        "output": "98"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1nc(C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CN)c(-c2cccc(Cl)c2)s1.Cn1nc(C(=O)O)c2ccccc21>>Cc1nc(C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2nn(C)c3ccccc23)c(-c2cccc(Cl)c2)s1",
        "output": "816"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COc1ccc(I)cc1.I[Cu]I.N[C@@H]1CCCC[C@H]1N.O=P([O-])([O-])[O-].[K+].[K+].[K+].c1ccc2c(c1)[nH]c1ccccc12>>COc1ccc(-n2c3ccccc3c3ccccc32)cc1",
        "output": "267"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CI.CN(C)C=O.O=C([O-])[O-].O=C1CCc2ccc(O)cc2N1.[K+].[K+]>>COc1ccc2c(c1)NC(=O)CC2",
        "output": "62"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)c1ccncc1.COc1ccc(C(=O)O)c(OC)c1.COc1ccc(N)cc1.Nc1ccc(OC2CCCCO2)cc1>>COc1ccc(C(=O)Nc2ccc(OC3CCCCO3)cc2)c(OC)c1",
        "output": "817"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(=O)Nc1nc(CCc2ccc(CC(=O)N3CCN(C(=O)OC(C)(C)C)CC3)s2)cs1.CO.Cl>>CC(=O)Nc1nc(CCc2ccc(CC(=O)N3CCNCC3)s2)cs1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCCOC.Ic1ccc(Oc2cncc3sccc23)cc1.O.O=C([O-])[O-].OB(O)c1ccc(C(F)(F)F)cc1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>FC(F)(F)c1ccc(-c2ccc(Oc3cncc4sccc34)cc2)cc1",
        "output": "855"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C(c1ccccc1)c1cccc(CC(=O)O)c1.O=S(Cl)Cl>>CN(C)C(c1ccccc1)c1cccc(CC(=O)Cl)c1",
        "output": "53"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCOC(=O)[C@@H]1CNCC[C@H]1N(C)Cc1ccccc1.Cc1ccc(S(=O)(=O)OCCc2ccc(F)cc2)cc1.Cl.Cl.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)[C@@H]1CN(CCc2ccc(F)cc2)CC[C@H]1N(C)Cc1ccccc1",
        "output": "429"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCc1ccc(S(=O)(=O)c2ccccc2)cc1S(=O)(=O)Cl.NC1CCOCC1>>CCCc1ccc(S(=O)(=O)c2ccccc2)cc1S(=O)(=O)NC1CCOCC1",
        "output": "43"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nn1nc(-c2ccccc2)c2ccsc2c1=O.O=C(O)Cc1cc(F)cc(F)c1>>O=C(Cc1cc(F)cc(F)c1)Nn1nc(-c2ccccc2)c2ccsc2c1=O",
        "output": "459"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(O)Cn1ccc(N)n1.Cc1cc([C@@H](CC2CCOCC2)C(=O)O)ccc1S(C)(=O)=O.Cc1cccc(C)n1.ClCCl.O=C(Cl)C(=O)Cl>>Cc1cc([C@@H](CC2CCOCC2)C(=O)Nc2ccn(CC(C)(C)O)n2)ccc1S(C)(=O)=O",
        "output": "795"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COC(=O)c1cc(C2CC2)ccc1Nc1ccc2[nH]ccc2c1.FC(F)(F)c1ccc(I)cc1.O=C([O-])[O-].[Cs+].[Cs+].[Cu]I>>COC(=O)c1cc(C2CC2)ccc1Nc1ccc2c(ccn2-c2ccc(C(F)(F)F)cc2)c1",
        "output": "267"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN.CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cc1c(Cl)cc(C(C)O)c(-c2cc(F)cc(F)c2)c1C(=O)O.Cl.F[P-](F)(F)(F)(F)F>>CCNC(=O)c1c(C)c(Cl)cc(C(C)O)c1-c1cc(F)cc(F)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.N#Cc1ccc(C#CCCO)cc1.[H][H].[Pd]>>N#Cc1ccc(CCCCO)cc1",
        "output": "717"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.ClCCl.O.O=C(Cl)C(=O)Cl.O=C1Nc2ccc(F)cc2C1=C1OCc2cc(CCCO)ccc21>>O=CCCc1ccc2c(c1)COC2=C1C(=O)Nc2ccc(F)cc21",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCCBr.O=C(O)C(F)(F)F.Oc1cc(OC2CCOCC2)c2c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)ncnc2c1>>Fc1cccc(COc2ccc(Nc3ncnc4cc(OCCCCl)cc(OC5CCOCC5)c34)cc2Cl)c1",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.NC1CC1.O.O=C(O)c1ccc2cc(Br)ccc2c1.On1nnc2ccccc21>>O=C(NC1CC1)c1ccc2cc(Br)ccc2c1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O.COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=S)Nc4ccccc4F)cc3)cc2C1=O.COc1ccccc1N=C=S>>COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=S)Nc4ccccc4OC)cc3)cc2C1=O",
        "output": "474"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)Cc1c(C)n(Cc2ccc(OCc3ccccc3)cc2)c2ccc(OC)cc12.CO.Cl.O.[Na+].[OH-]>>COc1ccc2c(c1)c(CC(=O)O)c(C)n2Cc1ccc(OCc2ccccc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cl.Clc1ccnc(Cl)n1.N#Cc1ccccc1N.O>>N#Cc1ccccc1Nc1ccnc(Cl)n1",
        "output": "161"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(CS(=O)(=O)Cl)c1ccc(-c2ccccc2F)cc1.CN>>CNS(=O)(=O)CC(C)c1ccc(-c2ccccc2F)cc1",
        "output": "493"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.Nc1cccc2ccccc12.O=C(Cl)c1ccccc1[N+](=O)[O-]>>O=C(Nc1cccc2ccccc12)c1ccccc1[N+](=O)[O-]",
        "output": "11"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)C(=O)Cl.Oc1ccc(F)c(Cl)c1>>CCN(CC)C(=O)Oc1ccc(F)c(Cl)c1",
        "output": "425"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.ClCCCCBr.O.O=C([O-])[O-].Oc1cccc2c1c1cccc3c1n2C(c1ccccc1)CO3.[K+].[K+]>>ClCCCCOc1cccc2c1c1cccc3c1n2C(c1ccccc1)CO3",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)C(O)CC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1.CN(C)C=O.O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1>>CC(C)C(=O)CC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1",
        "output": "87"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCC.COC(=O)c1ccc(Cl)c2c1C=CC(C)(C)O2>>CC1(C)C=Cc2c(CO)ccc(Cl)c2O1",
        "output": "444"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.O=C(O)c1cccc(Br)n1.O=S(Cl)Cl>>CCOC(=O)c1cccc(Br)n1",
        "output": "331"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.OC1CCc2c(Br)cccc21.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OC1CCc2c(Br)cccc21",
        "output": "193"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2c(c1)c(-c1cccc(C#C[Si](C)(C)C)c1)cc(=O)n2C.[F-]>>C#Cc1cccc(-c2cc(=O)n(C)c3ccc(C(O)(c4ccc(Cl)cc4)c4cncn4C)cc23)c1",
        "output": "337"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(N)(CO)CO.CCN(CC)CC.O.O=[N+]([O-])c1cccc(S(=O)(=O)Cl)c1>>CC(CO)(CO)NS(=O)(=O)c1cccc([N+](=O)[O-])c1",
        "output": "43"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.CO.CO.COC(COCCOCCOCCOCCOC(C)=O)OC.ClC(Cl)Cl.[Na+].[OH-]>>COC(COCCOCCOCCOCCO)OC",
        "output": "225"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.CS(C)=O.Cl[Pd]Cl.OCCc1cccc(Br)c1.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2cccc(CCO)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)Nc1cccc2ccc(O)cc12.CC(C)[Si](Cl)(C(C)C)C(C)C.CN(C)C=O.O=C(O)CC(O)(CC(=O)O)C(=O)O.c1c[nH]cn1>>CC(C)[Si](Oc1ccc2cccc(NC(=O)OC(C)(C)C)c2c1)(C(C)C)C(C)C",
        "output": "746"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=O.CC(=O)O.CO.Cc1nc2ccc3c(c2o1)OC(CNCCCc1c[nH]c2ccc(F)cc12)CO3.[BH3-]C#N.[Na+]>>Cc1nc2ccc3c(c2o1)OC(CN(C)CCCc1c[nH]c2ccc(F)cc12)CO3",
        "output": "217"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)c1ccc(C(=O)O)nc1.Cl.[BH4-].[Li+]>>O=C(O)c1ccc(CO)cn1",
        "output": "522"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=C(O)c1ccc(F)cc1S.O=S(=O)(O)O>>COC(=O)c1ccc(F)cc1S",
        "output": "33"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(O)c1ccc(Cl)cc1.O=C1CC(c2ccccc2)c2ccccc2N1>>O=C1CC(c2ccccc2)c2cc(C(=O)c3ccc(Cl)cc3)ccc2N1",
        "output": "275"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CN1CCN(c2ccc(Nc3nc(N)c(C(=O)c4ccc(Cl)c([N+](=O)[O-])c4)s3)cc2)CC1.NCCO>>CN1CCN(c2ccc(Nc3nc(N)c(C(=O)c4ccc(NCCO)c([N+](=O)[O-])c4)s3)cc2)CC1",
        "output": "304"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc(Br)cnc1OC.COc1ccc(B(O)O)cc1>>COc1ccc(-c2cnc(OC)c(OC)c2)cc1",
        "output": "833"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)c1ccc(N)cc1.O=Cc1ccc(Cl)cc1Cl>>CC(C)c1ccc(NCc2ccc(Cl)cc2Cl)cc1",
        "output": "359"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(-n2ccnc2)ccc1[N+](=O)[O-].[Pd]>>Cc1cc(-n2ccnc2)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCCCCC(C)c1ccc(COC(C)=O)cc1.CO.[K+].[OH-]>>CCCCCCCCCC(C)c1ccc(CO)cc1",
        "output": "497"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Clc1nccnc1Cl.Nc1nc2c(OCCO)cccc2o1.[H-].[Na+]>>Nc1nc2c(OCCOc3nccnc3Cl)cccc2o1",
        "output": "209"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NC1CCOCC1CO.CCCCP(CCCC)CCCC.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.Oc1ccc(-c2ncc(Cl)cc2F)cc1.[Na+].[OH-]>>CC(C)(C)OC(=O)NC1CCOCC1COc1ccc(-c2ncc(Cl)cc2F)cc1",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=O.CO.Cc1c(OCC2CCNCC2)nn(-c2ccccc2)c1NC(=O)NCc1ccccc1OC(F)(F)F.O=CO>>Cc1c(OCC2CCN(C)CC2)nn(-c2ccccc2)c1NC(=O)NCc1ccccc1OC(F)(F)F",
        "output": "217"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cl.O.O.O=C1CCNCC1.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(=O)CC1",
        "output": "694"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCc1cnn(C)c1-c1cc(C(=O)OC)sc1CC.[Na+].[OH-]>>CCc1cnn(C)c1-c1cc(C(=O)O)sc1CC",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[O-].CN1CCCC1=O.ClCCl.OC1CCCC1.[K+].[O-][n+]1c(Cl)cc(Cl)c2c1CCC2>>[O-][n+]1c(OC2CCCC2)cc(Cl)c2c1CCC2",
        "output": "433"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.C[Si](C)(C)CCO.ClCCCl.O=C(Cl)c1cccc([N+](=O)[O-])c1>>C[Si](C)(C)CCOC(=O)c1cccc([N+](=O)[O-])c1",
        "output": "51"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CO.COC(=O)CCNS(=O)(=O)c1ccccc1[N+](=O)[O-].Cl.[Na+].[OH-]>>O=C(O)CCNS(=O)(=O)c1ccccc1[N+](=O)[O-]",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C(#Cc1ccccc1)C1=NOC2(CCNCC2)C1.CC(=O)N(C)C.CCN(CC)CC.Cc1ccc([N+](=O)[O-])c(Cl)n1.O>>Cc1ccc([N+](=O)[O-])c(N2CCC3(CC2)CC(C#Cc2ccccc2)=NO3)n1",
        "output": "220"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCCCOc1ccccc1.CCO.O=C([O-])[O-].[K+].[K+].c1ccc(C2CCNCC2)cc1>>c1ccc(OCCCN2CCC(c3ccccc3)CC2)cc1",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC(NC2CCCCC2)CC1.CCN(C(C)C)C(C)C.COc1ccc([N+](=O)[O-])cc1OCC(=O)Cl.COc1ccc([N+](=O)[O-])cc1OCC(=O)O.ClCCl.O=S(Cl)Cl>>COc1ccc([N+](=O)[O-])cc1OCC(=O)N(C1CCCCC1)C1CCCCC1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)NS(=O)(=O)c1ccc(-c2cccc(-c3nc(-c4ccc(C(F)(F)F)cc4)cc(C(F)(F)F)n3)c2)s1.ClCCl.O=C(O)C(F)(F)F>>NS(=O)(=O)c1ccc(-c2cccc(-c3nc(-c4ccc(C(F)(F)F)cc4)cc(C(F)(F)F)n3)c2)s1",
        "output": "680"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCO.Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CC=O)c2cc1C.NCc1ccc(Cl)c(Cl)c1.[BH3-]C#N.[Na+]>>Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(CCNCc3ccc(Cl)c(Cl)c3)c2cc1C",
        "output": "627"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCc1c(NC(C)=O)ccc(C(C)=O)c1O.CCO.Cl>>CCCc1c(N)ccc(C(C)=O)c1O",
        "output": "66"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.CN(C)c1ccccn1.C[C@@H]1CC[C@@]2(OC1)O[C@H]1C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O[Si](C)(C)C(C)(C)C)CC[C@]5(C)[C@H]4[C@@H](O)[C@@H](O)[C@]3(C)[C@H]1[C@@H]2C.ClCCl.c1ccncc1>>CC(=O)O[C@@H]1[C@H](O)[C@H]2[C@@H](CC[C@H]3C[C@@H](O[Si](C)(C)C(C)(C)C)CC[C@@]32C)[C@@H]2C[C@@H]3O[C@]4(CC[C@@H](C)CO4)[C@@H](C)[C@@H]3[C@@]12C",
        "output": "254"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CO.COC(=O)c1sc2ccccc2c1NS(=O)(=O)c1ccc(C(C)(C)C)cc1.Cl.[Na+].[OH-]>>CC(C)(C)c1ccc(S(=O)(=O)Nc2c(C(=O)O)sc3ccccc23)cc1",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(=O)NC[C@@H]1OC(=O)N2c3ccc(Br)cc3C[C@@H]12.Cn1nnc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cn2)n1.O.O=C([O-])[O-].[K+].[K+]>>CC(=O)NC[C@@H]1OC(=O)N2c3ccc(-c4ccc(-c5nnn(C)n5)nc4)cc3C[C@@H]12",
        "output": "954"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "N#Cc1ccc(C(=O)C=C2NC(Cc3ccncc3)(Cc3ccncc3)C(=O)N2CC2CCNC2)cc1.O=S(=O)(Cl)c1ccccc1>>N#Cc1ccc(C(=O)C=C2NC(Cc3ccncc3)(Cc3ccncc3)C(=O)N2CC2CCN(S(=O)(=O)c3ccccc3)C2)cc1",
        "output": "99"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N1CCN(c2ccc(N)cc2)CC1.CCC(CC)n1c(=O)[nH]c2cnc(Cl)nc21.CCOC(C)=O.CN(C)C=O.Cc1ccc(S(=O)(=O)O)cc1>>CCC(CC)n1c(=O)[nH]c2cnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)nc21",
        "output": "592"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OB(c2ccc(N3CCC3)nc2)OC1(C)C.Cc1nn(C)cc1-n1c(=O)n(C)c2cnc3ccc(Br)cc3c21>>Cc1nn(C)cc1-n1c(=O)n(C)c2cnc3ccc(-c4ccc(N5CCC5)nc4)cc3c21",
        "output": "954"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)C1CCC(=O)CC1.CC(C)(C)c1ccc(C2CCNC2)cc1.CO.[BH3-]C#N.[Cl-].[Cl-].[Na+].[Zn+2]>>CC(C)(C)c1ccc(C2CCN(C3CCC(C(C)(C)C)CC3)C2)cc1",
        "output": "187"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.O=C([O-])O.O=S(Cl)Cl.OCc1ccc(OCc2ccccc2)nc1.[Na+]>>ClCc1ccc(OCc2ccccc2)nc1",
        "output": "477"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COc1cc(C(C)=O)cc(C(C)C)c1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Br-].[Br-].[Br-]>>COc1cc(C(=O)CBr)cc(C(C)C)c1",
        "output": "360"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCn1c2ccccc2c2cc(Nc3nccc(-c4ccc(N5CCN(C(=O)OC(C)(C)C)CC5)nc4)n3)ccc21.ClCCl.O=C(O)C(F)(F)F>>CCn1c2ccccc2c2cc(Nc3nccc(-c4ccc(N5CCNCC5)nc4)n3)ccc21",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CNC.C[C@@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.ClCCl.F[B-](F)(F)F.O>>C[C@@H](NC(=O)OC(C)(C)C)C(=O)N(C)C",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1cccc(F)c1NC(=O)C(F)(F)F.CO.[Na+].[OH-]>>CC(=O)c1cccc(F)c1N",
        "output": "491"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1nn(-c2ccccc2)c2c1CSc1ccc(C(=O)OC(C)(C)C)cc1-2.O=C(O)C(F)(F)F>>CCOC(=O)c1nn(-c2ccccc2)c2c1CSc1ccc(C(=O)O)cc1-2",
        "output": "752"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CC=C(c2nc(C3CCC3)n3ccnc(N)c23)CC1.Cl>>Nc1nccn2c(C3CCC3)nc(C3=CCNCC3)c12",
        "output": "800"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1csc(Cc2ccc(C(C)=O)s2)n1.Cl.N#N.[Na+].[OH-]>>CC(=O)c1ccc(Cc2nc(C(=O)O)cs2)s1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cc1noc(C)c1-c1cc(C(O)(c2ccccn2)C2CCCC2=O)c2nc(C3CC3)[nH]c2c1.[BH4-].[Na+]>>Cc1noc(C)c1-c1cc(C(O)(c2ccccn2)C2CCCC2O)c2nc(C3CC3)[nH]c2c1",
        "output": "91"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCOC(=O)Cc1c(C)ncnc1O.ClCCl.O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+]>>CCOC(=O)Cc1c(C)ncnc1Cl",
        "output": "25"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=C(O)CNc1ccccc1.O=S(=O)(O)O>>COC(=O)CNc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCCCCOc1ccc2nccn2c1.Clc1ccccc1N1CCNCC1>>Clc1ccccc1N1CCN(CCCCOc2ccc3nccn3c2)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Cc1ccc(C(=O)O)cc1I.II.[BH4-].[Na+]>>Cc1ccc(CO)cc1I",
        "output": "72"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=O.O.OCCN1CCNCC1.[BH3-]C#N.[Na+]>>CN1CCN(CCO)CC1",
        "output": "217"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NCc1ccc(-c2csc(N)n2)cc1.CCN(CC)CC.ClCCl.O=C(Cl)C1CC1>>CC(C)(C)OC(=O)NCc1ccc(-c2csc(NC(=O)C3CC3)n2)cc1",
        "output": "553"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)Cl.COCCOC.Nc1ccc([N+](=O)[O-])c(NCCc2ccccc2)c1.c1ccncc1>>COC(=O)Nc1ccc([N+](=O)[O-])c(NCCc2ccccc2)c1",
        "output": "102"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)c1cccc(N2CCCC2=O)c1F.[Li+].[OH-]>>O=C(O)c1cccc(N2CCCC2=O)c1F",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCc1sc(-c2ccc(C(F)(F)F)cc2)nc1CC(=O)OC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCc1sc(-c2ccc(C(F)(F)F)cc2)nc1CCO",
        "output": "343"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)c1ccncc1.Cc1cccc(S(=O)(=O)Cl)c1.Nc1cccc2cccnc12>>Cc1cccc(S(=O)(=O)Nc2cccc3cccnc23)c1",
        "output": "554"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC1CO1.Fc1ccc2c(C3CCNCC3)noc2c1>>CC(O)CN1CCC(c2noc3cc(F)ccc23)CC1",
        "output": "76"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)NC1CCN(CCOc2cc(C)n(-c3ccc(Cl)c(Cl)c3)n2)C1.Cl.O.[Na+].[OH-]>>Cc1cc(OCCN2CCC(N)C2)nn1-c1ccc(Cl)c(Cl)c1",
        "output": "412"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCc1nc(C(C)N2CCOCC2)cc(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1nc(C(C)N2CCOCC2)cc(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)OCc1c(-c2ccnc3[nH]c(-c4cnn(C)c4)nc23)ccnc1N1CCn2c(cc3c2CC(C)(C)C3)C1=O.O.[Na+].[OH-]>>Cn1cc(-c2nc3c(-c4ccnc(N5CCn6c(cc7c6CC(C)(C)C7)C5=O)c4CO)ccnc3[nH]2)cn1",
        "output": "348"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCCCOc1ccc(-c2cnc3[nH]c4cnc(-c5cccnc5)cc4c3c2)cc1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>NCCCOc1ccc(-c2cnc3[nH]c4cnc(-c5cccnc5)cc4c3c2)cc1",
        "output": "538"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CON.Cc1cccc(C)c1N(CCC=O)C(=O)CCl.Cl.O=C([O-])O.[Na+]>>CON=CCCN(C(=O)CCl)c1c(C)cccc1C",
        "output": "118"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC(N)C2)C1.CCN(C(C)C)C(C)C.CCOC(C)=O.CS(C)=O.Fc1cccc(Cn2cnc3ccc(-c4cc(F)ncc4Cl)cc32)c1.O>>CC(C)(C)OC(=O)N1CCC2(CC(Nc3cc(-c4ccc5ncn(Cc6cccc(F)c6)c5c4)c(Cl)cn3)C2)C1",
        "output": "810"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(CC)C(N)c1ccnn1S(=O)(=O)c1ccc(C)cc1.CCN(CC)CC.ClC(Cl)Cl.ClCCl.O=S(=O)(Cl)c1ccc(Cl)s1>>CCC(CC)C(NS(=O)(=O)c1ccc(Cl)s1)c1ccnn1S(=O)(=O)c1ccc(C)cc1",
        "output": "600"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(=O)c1ccc(CBr)cc1.O=C([O-])[O-].O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNC[C@H]1Cc1c[nH]c2ccccc12.[K+].[K+]>>CC(=O)c1ccc(CN2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](Cc3c[nH]c4ccccc34)C2)cc1",
        "output": "248"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(C)=O.Cc1cc(C(=O)NS(C)(=O)=O)ccc1-c1cnc(F)c(Cl)c1.Cc1cc(Cl)cc(Cl)c1O.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1cc(C(=O)NS(C)(=O)=O)ccc1-c1cnc(Oc2c(C)cc(Cl)cc2Cl)c(Cl)c1",
        "output": "727"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc(C2(C#N)CCCCC2)c1.O.O.[Li+].[OH-]>>N#CC1(c2cccc(C(=O)O)c2)CCCCC1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)[Si](OC1CN(c2nc(CNS(=O)(=O)c3ccccc3)cs2)C1)(c1ccccc1)c1ccccc1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>O=S(=O)(NCc1csc(N2CC(O)C2)n1)c1ccccc1",
        "output": "781"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)Cn1ncc2cc(Oc3ccc(F)cc3C#N)ccc21.ClCCl.[BH4-].[Na+]>>N#Cc1cc(F)ccc1Oc1ccc2c(cnn2CCO)c1",
        "output": "343"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)C(C)c1ccc(CC=C(C)C)cc1.O.[Na+].[OH-]>>CC(C)=CCc1ccc(C(C)C(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cn(C)c(=O)c(C)c1Cl.CO.Cl.[Li+].[OH-]>>Cc1c(Cl)c(C(=O)O)cn(C)c1=O",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Cl)n2)s1.CS(=O)(=O)CCN.Cl>>CC(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2)c(-c2ccnc(NCCS(C)(=O)=O)n2)s1",
        "output": "544"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN1CCN(C)C1=O.COc1ccc2c3c(c(=O)oc2c1)CNCC3.Cc1ccc(C=O)cc1.[Na+]>>COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccc(C)cc1)CC3",
        "output": "567"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNC(=O)COc1cccc(S(=O)(=O)n2cc(CN(C)C(=O)OC(C)(C)C)cc2-c2ccccc2F)c1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CNCc1cc(-c2ccccc2F)n(S(=O)(=O)c2cccc(OCC(=O)NC)c2)c1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.Cc1cn2cc(-c3ccccc3)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)nc2n1.Cl>>Cc1cn2cc(-c3ccccc3)c(-c3ccc(C4(N)CCC4)cc3)nc2n1",
        "output": "793"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCN1.CC(=O)N(C)C.CCN(C(C)C)C(C)C.COc1cccc(-c2cc(N)[nH]n2)c1.COc1cccc(-c2cc(NC(=O)CCCBr)n[nH]2)c1.ClCCl.O=C(Cl)CCCBr>>COc1cccc(-c2cc(NC(=O)CCCN3CCOCC3)n[nH]2)c1",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Cl.O=C(Nc1cccc(Nc2ncccc2[N+](=O)[O-])c1)c1ccc2ccccc2c1.O=C([O-])O.[Fe].[Na+]>>Nc1cccnc1Nc1cccc(NC(=O)c2ccc3ccccc3c2)c1",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1cc(C2CCCCC2)cc(CC)c1N.ClCCl.O.O=C([O-])[O-].S=C(Cl)Cl.[Ca+2]>>CCc1cc(C2CCCCC2)cc(CC)c1N=C=S",
        "output": "114"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Fc1ccccc1Br.Oc1ccc(F)cc1.[Cu].[K+].[OH-]>>Fc1ccc(Oc2ccccc2F)cc1",
        "output": "238"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCC.COCCOC.Clc1cc(C(Cl)(Cl)Cl)cc(Cl)n1.O.OCc1ccco1.[H-].[Na+]>>Clc1cc(C(Cl)(Cl)Cl)cc(OCc2ccco2)n1",
        "output": "433"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C.CC(=O)N(C)C.Nc1ccc(S(=O)(=O)c2ccccc2)cc1.O=C(O)C1(O)CC1.O=S(Cl)Cl>>O=C(Nc1ccc(S(=O)(=O)c2ccccc2)cc1)C1(O)CC1",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)N=C=NC(C)C.CN(C)C=O.CNCc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C.ClCCl.O=C(O)CCc1ccccc1>>Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CCc2ccccc2)c1C",
        "output": "633"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[O-].CS(C)=O.Fc1cc(F)cc(Br)c1.O.OCC(F)(F)F.[K+]>>Fc1cc(Br)cc(OCC(F)(F)F)c1",
        "output": "485"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1nc(N)ccc1-n1cnc(C)c1.Cc1csc(C2CN(C)Cc3ccc(Cl)nc3O2)n1>>COc1nc(Nc2ccc3c(n2)OC(c2nc(C)cs2)CN(C)C3)ccc1-n1cnc(C)c1",
        "output": "606"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1sc(NC(=O)OC(C)(C)C)nc1C.CO.[Na+].[OH-]>>Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.Cl.N#Cc1ccc(C=O)cc1.O=C(O)CC(=O)O.c1ccncc1>>N#Cc1ccc(C=CC(=O)O)cc1",
        "output": "12"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3Cc2ccccc2OCC)cc1.CO.Cl.O.[Na+].[OH-]>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCN3Cc2ccccc2OCC)cc1",
        "output": "58"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.COc1ccc(Br)nc1C(=O)O.ClCCl.NCc1ccc(Cl)cc1.O>>COc1ccc(Br)nc1C(=O)NCc1ccc(Cl)cc1",
        "output": "905"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1cc(Oc2ccc(C(=O)OC(C)(C)C)nc2)c2c(c1)OC(C)(C)C2.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1cc(Oc2ccc(C(=O)O)nc2)c2c(c1)OC(C)(C)C2",
        "output": "569"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=Cc1ccc(OC)c(N)c1.CCN(C(C)C)C(C)C.CN(C)C=O.Clc1ncc(Cl)c(Cl)n1>>C=Cc1ccc(OC)c(Nc2nc(Cl)ncc2Cl)c1",
        "output": "352"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(O)C1CCNCC1.ClCCCl.O=C([O-])O.O=Cc1nc2c(N3CCOCC3)nc(Cl)nc2n1C1CCCCO1.[Na+].[Na+]>>CC(C)(O)C1CCN(Cc2nc3c(N4CCOCC4)nc(Cl)nc3n2C2CCCCO2)CC1",
        "output": "944"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(C)=O.C[C@@H](c1ccc(-c2ccc(C#N)cn2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O.O=C([O-])[O-].OO.[K+].[K+]>>C[C@@H](c1ccc(-c2ccc(C(N)=O)cn2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O",
        "output": "677"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CC(C)(C)OC(=O)NC1CCC(C(=O)O)CC1.CCN=C=NCCCN(C)C.CN1CCCC1=O.On1nnc2ccccc21>>CC(C)(C)OC(=O)NC1CCC(C(=O)N2CCOCC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cl.O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2cccc(Cl)c2)CN1.O=C(O)Cn1ccnn1>>O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2cccc(Cl)c2)CN1C(=O)Cn1ccnn1",
        "output": "297"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COc1ccc(C2COc3cc(OC)ccc3C2=O)cc1.Cl.NO.c1ccncc1>>COc1ccc(C2COc3cc(OC)ccc3C2=NO)cc1",
        "output": "212"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.COC(=O)c1cccc([N+](=O)[O-])c1N.[H][H].[Pd]>>COC(=O)c1cccc(N)c1N",
        "output": "481"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCc1nc2cc(N(Cc3cccc(F)c3)S(=O)(=O)c3ccc(F)cc3)ccc2n1CC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>CCCc1nc2cc(N(Cc3cccc(F)c3)S(=O)(=O)c3ccc(F)cc3)ccc2n1CC(=O)O",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(C)(C)O.Cl.ClCCl.NCCCO.O=C([O-])O.[Na+].[O-][n+]1ccccc1Cl>>[O-][n+]1ccccc1NCCCO",
        "output": "70"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc(Nc2cncc(Cl)n2)cc(OC)c1OC.Nc1ccncc1>>COc1cc(Nc2cncc(Nc3ccncc3)n2)cc(OC)c1OC",
        "output": "780"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOCC.CN1COc2cc(I)cc3c(=O)c(C(=O)O)cn1c23.NCc1ccc(Cl)cc1.O=C(n1ccnc1)n1ccnc1>>CN1COc2cc(I)cc3c(=O)c(C(=O)NCc4ccc(Cl)cc4)cn1c23",
        "output": "790"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)N=C=NC(C)C.CCOC(=O)c1ccc(N)cc1.CN(C)C=O.COc1cn(C(CC(F)F)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1C#N>>CCOC(=O)c1ccc(NC(=O)C(CC(F)F)n2cc(OC)c(-c3cc(Cl)ccc3C#N)cc2=O)cc1",
        "output": "710"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)C1(NS(=O)(=O)c2c(C)cc(OC)cc2C)CCC1.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>COc1cc(C)c(S(=O)(=O)NC2(CO)CCC2)c(C)c1",
        "output": "343"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOc1cc(C(=O)OC)ccc1-c1ccc(F)cc1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CCOc1cc(CO)ccc1-c1ccc(F)cc1",
        "output": "444"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)c1ccccc1.O=P(Cl)(Cl)Cl.Oc1nc(-c2ccc(N3CCOCC3)cc2)cc2ncccc12>>Clc1nc(-c2ccc(N3CCOCC3)cc2)cc2ncccc12",
        "output": "168"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COCCOC.Cl.O.O=C([O-])c1cc2ccccc2cc1OCc1ccccc1.[BH4-].[Na+].[Na+]>>OCc1cc2ccccc2cc1OCc1ccccc1",
        "output": "72"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Brc1ccccc1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.COCCOC.FC(F)c1nc2ccccc2n1-c1cc(N2CCOCC2)nc(NCC2CCNCC2)n1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>FC(F)c1nc2ccccc2n1-c1cc(N2CCOCC2)nc(NCC2CCN(c3ccccc3)CC2)n1",
        "output": "294"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CN(C)CCOC1CCN(Cc2ccccc2)C1.[H][H]>>CN(C)CCOC1CCNC1",
        "output": "84"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCOCC.ClCCl.O=C([O-])O.O=S([O-])([O-])=S.OCCCc1cccnc1.[Na+].[Na+].[Na+]>>O=CCCc1cccnc1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NC1CCCc2c1[nH]c1ccc(Cl)cc21.O=C(O)c1c[nH]cn1>>O=C(NC1CCCc2c1[nH]c1ccc(Cl)cc21)c1c[nH]cn1",
        "output": "697"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)OC)cc2OCCCC)c1.CO.[Na+].[OH-]>>CCCCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)O)cc2OCCCC)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCI.CN(C)C=O.O=C([O-])[O-].O=C(c1cccs1)c1cnc2c(cnn2Cc2ccco2)c1O.[K+].[K+]>>CCOc1c(C(=O)c2cccs2)cnc2c1cnn2Cc1ccco1",
        "output": "198"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)OC2C(O)OC(CO)C2O1.CCN(CC)CC.CN(C)C=O.CN(C)c1ccncc1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1>>CC1(C)OC2C(O)OC(COC(c3ccccc3)(c3ccccc3)c3ccccc3)C2O1",
        "output": "250"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.Cn1c(C#N)ccc1-c1ccc2c(c1)C(C)(C)OC(=O)N2C(=O)OC(C)(C)C.O.O=C1CCC(=O)N1Br.c1ccncc1>>Cn1c(C#N)cc(Br)c1-c1ccc2c(c1)C(C)(C)OC(=O)N2C(=O)OC(C)(C)C",
        "output": "796"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCC[PH](=O)O[PH](=O)CCC.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.NCc1cccc(C(F)(F)F)c1.O=C(O)C1CCc2c(sc3ncnc(Nc4ccc5[nH]ncc5c4)c23)C1>>O=C(NCc1cccc(C(F)(F)F)c1)C1CCc2c(sc3ncnc(Nc4ccc5[nH]ncc5c4)c23)C1",
        "output": "599"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(CO)c1cccc(C#N)c1.CCOC(C)=O.ClCCl.O.O=C([O-])O.O=S([O-])[O-].[Na+].[Na+].[Na+]>>CC(C)(C=O)c1cccc(C#N)c1",
        "output": "142"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)(C)c1ccc(N)cc1.[Zn]>>CC(=O)Nc1ccc(C(C)(C)C)cc1",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.C1CCOC1.COC(=O)c1ccc2nc(-c3ccc(Cl)cc3)c(CO)n2c1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OCc1ccc2nc(-c3ccc(Cl)cc3)c(CO)n2c1",
        "output": "522"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.Cc1ccc(S(=O)(=O)OCCC2CN(Cc3ccc(C(F)(F)F)cc3)C(=O)N2C)cc1.O=C(OC1CCCC1)C(Cc1ccc(O)cc1)OC1CCCC1.O=C([O-])[O-].[Cs+].[Cs+]>>CN1C(=O)N(Cc2ccc(C(F)(F)F)cc2)CC1CCOc1ccc(CC(OC2CCCC2)C(=O)OC2CCCC2)cc1",
        "output": "438"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.Cc1nc(N)sc1C(=O)NCc1ccccc1.ClCCl.O=C(Cl)CCCCBr>>Cc1nc(NC(=O)CCCCBr)sc1C(=O)NCc1ccccc1",
        "output": "553"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N(Cc1ccc([N+](=O)[O-])cc1)[C@H]1CCC[C@@H](Nc2ncc(Cl)c(-c3cn(S(=O)(=O)c4ccccc4)c4ccccc34)n2)C1.CCOC(C)=O.CO.O.[BH4-].[Na+]>>CC(C)(C)OC(=O)N(Cc1ccc(N)cc1)[C@H]1CCC[C@@H](Nc2ncc(Cl)c(-c3cn(S(=O)(=O)c4ccccc4)c4ccccc34)n2)C1",
        "output": "507"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)c1ccncc1.Cl.FC1(F)CNCC(COc2ccc(Cl)cc2)C1.O=C(O)c1cccc(-c2ccco2)c1>>O=C(c1cccc(-c2ccco2)c1)N1CC(COc2ccc(Cl)cc2)CC(F)(F)C1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)N=NC(=O)OCC.COc1cc2c(Cl)c(C#N)cnc2cc1O.ClCCl.OCCCc1ccncc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc2c(Cl)c(C#N)cnc2cc1OCCCc1ccncc1",
        "output": "478"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COc1ccnc(COC(C)=O)c1.Cl.[Na+].[OH-]>>COc1ccnc(CO)c1",
        "output": "348"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)Cl.Cl.FC(F)(F)c1cc(CO[C@H]2CCNC[C@H]2c2ccccc2)cc(C(F)(F)F)c1>>COC(=O)N1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1",
        "output": "219"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)S(=O)(=O)NC1CC(F)(F)CC1N.CCN(C(C)C)C(C)C.CS(C)=O.FC(F)(F)c1cnc(Cl)cn1>>CC(C)(C)S(=O)(=O)NC1CC(F)(F)CC1Nc1cnc(C(F)(F)F)cn1",
        "output": "148"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)O)cc1Cl.ClCCl.N#Cc1ccc(-c2cnc(N)cn2)s1.O=C1CCC(=O)N1Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccncc1>>CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2cnc(-c3ccc(C#N)s3)cn2)cc1Cl",
        "output": "692"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(NS(=O)(=O)c2ccc(Cl)nc2)CC1.OC1CCN(c2ccc(C(F)(F)F)cc2)CC1.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCC(NS(=O)(=O)c2ccc(OC3CCN(c4ccc(C(F)(F)F)cc4)CC3)nc2)CC1",
        "output": "433"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC[C@H]1CCCN1Cc1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C#N)cc1.CCN(CC)CC.CCOC(C)=O.Cc1ccccc1.Cl.O.[N-]=[N+]=[N-].[Na+]>>CCC[C@H]1CCCN1Cc1c(Cl)cc(Cl)c(=O)n1CCc1ccc(-c2nnn[nH]2)cc1",
        "output": "390"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1=COCCC1.ClCCl.OCCCCBr>>BrCCCCOC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.COc1cccc(CN)c1.Cl.O=C(O)c1ccc(Br)cc1.On1nnc2ccccc21>>COc1cccc(CNC(=O)c2ccc(Br)cc2)c1",
        "output": "753"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN.Cc1cccc(C)c1N=C=S>>CCNC(=S)Nc1c(C)cccc1C",
        "output": "113"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=[N+]([O-])CC12CCCN1CCC2.[Ni]>>NCC12CCCN1CCC2",
        "output": "226"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(CC)CC.ClCCl.NCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21.O=C(Cl)c1c(Cl)cncc1Cl>>O=C(NCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21)c1c(Cl)cncc1Cl",
        "output": "271"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.C[O-].O.O=[N+]([O-])c1cc(Cl)cnc1Cl.[Na+]>>COc1ncc(Cl)cc1[N+](=O)[O-]",
        "output": "433"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CO.O=c1cc(O)c2c(NCc3ccccc3)ncnc2n1OCc1ccccc1.[C].[H][H].[OH-].[OH-].[Pd+2]>>O=c1cc(O)c2c(NCc3ccccc3)ncnc2n1O",
        "output": "630"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1>>CC(C)N1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1",
        "output": "187"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1=COCCC1.CCOCC.Cc1ccc(S(=O)(=O)O)cc1.O=C1CCC(O)CC1>>O=C1CCC(OC2CCCCO2)CC1",
        "output": "141"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "ClC(Cl)Cl.O=[Mn]=O.OCc1cnc(Cl)cn1>>O=Cc1cnc(Cl)cn1",
        "output": "287"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.O=[N+]([O-])c1cccc(-c2ccncc2)c1.OO>>O=[N+]([O-])c1cccc(-c2cc[n+]([O-])cc2)c1",
        "output": "396"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCN(C)CC3)CC2)cc(N)c1N>>Cc1nc2cc(C[C@@H](OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N3CCC(N4CCN(C)CC4)CC3)cc(C)c2[nH]1",
        "output": "512"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(C(=O)N2[C@@H](c3ccccc3)[C@@H](c3cnccn3)C[C@@]2(CC(C)C)C(=O)OC(C)(C)C)ccc1C(C)(C)C.O=C(O)C(F)(F)F>>COc1cc(C(=O)N2[C@@H](c3ccccc3)[C@@H](c3cnccn3)C[C@@]2(CC(C)C)C(=O)O)ccc1C(C)(C)C",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.NN.O.O=C(O)CCC(=O)c1ccc2ccc3cccc4ccc1c2c34.OCCOCCO.[K+].[OH-]>>O=C(O)CCCc1ccc2ccc3cccc4ccc1c2c34",
        "output": "92"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCCCC.CCOC(C)=O.COC(=O)CCc1cc(C(C)C)c(O)c(C(C)C)c1.O>>CC(C)c1cc(CCC(=O)O)cc(C(C)C)c1O",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.Nc1ccc(-n2cnc3ccncc32)cc1.O=C=Nc1ccc(Cl)c(C(F)(F)F)c1>>O=C(Nc1ccc(-n2cnc3ccncc32)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1",
        "output": "473"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)Cc1c(OCC2CC2)ccc2c(CCC3CCNCC3)noc12.O=Cc1ccc(Cl)cc1>>CN(C)Cc1c(OCC2CC2)ccc2c(CCC3CCN(Cc4ccc(Cl)cc4)CC3)noc12",
        "output": "567"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccnc(OC3CCN(C(=O)OC(C)(C)C)CC3)c2)cc1.Cl.ClCCl>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccnc(OC3CCNCC3)c2)cc1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.O.O=C([O-])O.OCCCCCCCCCCBr.[N-]=[N+]=[N-].[Na+].[Na+]>>[N-]=[N+]=NCCCCCCCCCCO",
        "output": "622"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(C)=O.Cl.O=C1COc2ccc(N3CCC4(CC3)OCCO4)cc2N1>>O=C1CCN(c2ccc3c(c2)NC(=O)CO3)CC1",
        "output": "251"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)CC1(O)C(=O)N(C2CCN(C(=O)OC(C)(C)C)CC2)c2ccccc21.CO.[BH4-].[Na+]>>CC(O)CC1(O)C(=O)N(C2CCN(C(=O)OC(C)(C)C)CC2)c2ccccc21",
        "output": "91"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)Cc1cc2ccc(Cl)cc2c(-c2ccc(S(=O)(=O)c3ccccc3C(F)(F)F)cc2)c1C.O.O.[Li+].[OH-]>>Cc1c(CC(=O)O)cc2ccc(Cl)cc2c1-c1ccc(S(=O)(=O)c2ccccc2C(F)(F)F)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOP(=O)(CN)OCC.ClCCl.O=[N+]([O-])c1cc([N+](=O)[O-])c2ccccc2c1Cl.c1ccc(Cc2ccccc2)cc1>>CCOP(=O)(CNc1c([N+](=O)[O-])cc([N+](=O)[O-])c2ccccc12)OCC",
        "output": "304"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)c1cn(C(COC)COC)c2ccc(I)cc2c1=O.O.[Li+].[OH-]>>COCC(COC)n1cc(C(=O)O)c(=O)c2cc(I)ccc21",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)(C)OC(=O)n1nc(C=O)c2ccc(Br)cc21.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(C)OC(=O)n1nc(C=O)c2ccc(B3OC(C)(C)C(C)(C)O3)cc21",
        "output": "934"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)N(CC[C@H](c1ccccc1)c1cc(CO)ccc1OCc1ccccc1)C(C)C.CO.[C].[Pd]>>CC(C)N(CC[C@H](c1ccccc1)c1cc(CO)ccc1O)C(C)C",
        "output": "23"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(CC(=O)O)cc1OCC.CCOC(C)=O.O.O=C(n1ccnc1)n1ccnc1.[BH4-].[Na+]>>CCOC(=O)c1ccc(CCO)cc1OCC",
        "output": "231"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1cc(C=O)c(C#CC(O)(c2ccccc2)c2ccccc2)n1Cc1ccccc1.Cl.O.[K+].[OH-]>>O=Cc1cc(C(=O)O)n(Cc2ccccc2)c1C#CC(O)(c1ccccc1)c1ccccc1",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COc1ccc(N(C)c2nc(CN)nc3ccccc23)cc1.Cl.ClCCl.O=C(Cl)c1cccnc1>>COc1ccc(N(C)c2nc(CNC(=O)c3cccnc3)nc3ccccc23)cc1",
        "output": "353"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.CCOC(C)=O.CO.COc1ccc(OC)c(C(=O)Cc2ccc(Cl)c(F)c2)c1.ClCCl.O>>O=C(Cc1ccc(Cl)c(F)c1)c1cc(O)ccc1O",
        "output": "20"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1nc(-c2c(F)c(F)c(F)c(F)c2F)cs1.O=C(O)c1cc(Cl)ccc1O>>O=C(Nc1nc(-c2c(F)c(F)c(F)c(F)c2F)cs1)c1cc(Cl)ccc1O",
        "output": "918"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cc1nc(NC(=O)OC(C)(C)C)ccc1CN.F[P-](F)(F)(F)(F)F.O=C(O)Cc1c(Cl)ccc(NCC(F)(F)c2ccccc2)c1F>>Cc1nc(NC(=O)OC(C)(C)C)ccc1CNC(=O)Cc1c(Cl)ccc(NCC(F)(F)c2ccccc2)c1F",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCC=O.CN(CCN)C(=O)OC(C)(C)C.CNCCNC(=O)OC(C)(C)C.CO.[BH3-]C#N.[Na+]>>CCCCCCCCCCN(C)CCNC(=O)OC(C)(C)C",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.COC(=O)/C(=C/c1cccc([N+](=O)[O-])c1)CC(=O)O>>COC(=O)/C(=C/c1cccc(N)c1)CC(=O)O",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.O=[N+]([O-])c1ccc(SCCn2cncn2)cc1.[Ca+2].[Cl-].[Cl-]>>Nc1ccc(SCCn2cncn2)cc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNOC.Cl.ClCCl.O=C(O)c1ccc2nc(-c3ccccc3)oc2c1.O=C(n1ccnc1)n1ccnc1>>CON(C)C(=O)c1ccc2nc(-c3ccccc3)oc2c1",
        "output": "828"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1CC(n2cc(N)cn2)C1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Cc1cnc(Cl)nc1CCc1ccccc1CC(N)=O.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2]>>Cc1cnc(Nc2cnn(C3CN(C(=O)OC(C)(C)C)C3)c2)nc1CCc1ccccc1CC(N)=O",
        "output": "992"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)[C@@H]1CC[C@@H](Nc2c(C(=O)C3CC3)cnc3ccc(Br)cc23)CC1.COc1cc(B2OC(C)(C)C(C)(C)O2)ccc1O>>COc1cc(-c2ccc3ncc(C(=O)C4CC4)c(N[C@@H]4CC[C@@H](N(C)C)CC4)c3c2)ccc1O",
        "output": "933"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.CCN(CC)CC.COC(=O)c1ccc(CN)cc1S(=O)(=O)NC(C)(C)C.ClCCl>>COC(=O)c1ccc(CNC(C)=O)cc1S(=O)(=O)NC(C)(C)C",
        "output": "206"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOCCl.CCOCOc1ccc(C=O)c(OCOCC)c1C.Cc1c(O)ccc(C=O)c1O>>CCOCOc1ccc(C=O)c(O)c1C",
        "output": "375"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1cccc(Br)n1.CC(C)(C)OC(=O)N1CCNCC1.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(c2cccc(Br)n2)CC1",
        "output": "647"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C.ClCCl.O=C([O-])O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.[Na+]>>COC(=O)[C@H](Cc1ccc(OS(=O)(=O)C(F)(F)F)cc1)NC(=O)OC(C)(C)C",
        "output": "731"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cccc2c1nc(C(F)F)n2-c1nc(Cl)nc(N2CCOCC2)n1.O=C(CCl)N1CC[NH2+]CC1.O=C([O-])C(F)(F)F>>COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(C(=O)CCl)CC2)n1",
        "output": "214"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.O=S(=O)(Nc1nccs1)c1ccc2c(-c3ccc(C(F)(F)F)cc3-c3ccnn3C3CNC3)cccc2c1.[Na+]>>CN1CC(n2nccc2-c2cc(C(F)(F)F)ccc2-c2cccc3cc(S(=O)(=O)Nc4nccs4)ccc23)C1",
        "output": "217"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CC(=O)[O-].CC(C)(C)OC(=O)Nc1ccc2cc(N)ccc2c1.O=C1CCC(=O)N1Br.[NH4+]>>CC(C)(C)OC(=O)Nc1ccc2c(Br)c(N)ccc2c1",
        "output": "4"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#Cc1cccnc1N.C1CCOC1.CCN(CC)CC.O.ON=C(Cl)Cc1ccc(COc2ccccc2)cc1>>Nc1ncccc1-c1cc(Cc2ccc(COc3ccccc3)cc2)no1",
        "output": "976"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.CCC(O)c1ccc(Cl)c2nc3n(c12)CCN3c1c(C)cc(Cl)cc1Cl.c1ccncc1>>CCC(OC(C)=O)c1ccc(Cl)c2nc3n(c12)CCN3c1c(C)cc(Cl)cc1Cl",
        "output": "254"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.O=C(O)c1cc(-c2ccc(F)cc2F)cc(I)c1O>>CCOC(=O)c1cc(-c2ccc(F)cc2F)cc(I)c1O",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1c(C(=O)O)[nH]c(C=O)c1C(=O)c1ccccc1.O=C1Cc2cc(Br)ccc2N1>>Cc1c(C(=O)O)[nH]c(C=C2C(=O)Nc3ccc(Br)cc32)c1C(=O)c1ccccc1",
        "output": "440"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)CC(C#N)CC(=O)O.CO.O=S(Cl)Cl>>COC(=O)CC(C#N)CC(C)C",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(NC2CCN(Cc3ccccc3)CC2)c1.CO.[C].[Pd]>>CC(C)(C)OC(=O)Nc1cccc(NC2CCNCC2)c1",
        "output": "84"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N[C@H]1CC[C@H](O)c2ccccc21>>CC(C)(C)OC(=O)N[C@H]1CC[C@H](O)c2ccccc21",
        "output": "686"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CNC.CO.O=CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc21.[BH3-]C#N.[Cl-].[Cl-].[Na+].[Zn+2]>>O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)c3nnn(CCO)c3n2)cc1",
        "output": "223"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1nc2c(NCc3ccccc3)ncnc2n1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O.Cl.[Na+].[OH-]>>O=C(O)c1nc2c(NCc3ccccc3)ncnc2n1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CCNC1.Fc1ccc(Br)cn1>>CC(C)(C)OC(=O)N[C@@H]1CCN(c2ccc(Br)cn2)C1",
        "output": "756"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#Cc1ccc(C)cc1.C1CCNC1.OCC1CCC(c2ccc(Br)cc2)CC1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Cc1ccc(C#Cc2ccc(C3CCC(CO)CC3)cc2)cc1",
        "output": "659"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.Cc1cccc(-c2ccc3ccc(N)nc3n2)c1.O.O=C(O)c1cccc(Br)c1>>Cc1cccc(-c2ccc3ccc(NC(=O)c4cccc(Br)c4)nc3n2)c1",
        "output": "744"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2ccc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)nc2)c(F)c1.O.[Li]O>>O=C(O)c1ccc(-c2ccc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)nc2)c(F)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc(-c2ccccc2C#N)cc1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>N#Cc1ccccc1-c1ccc(CBr)cc1",
        "output": "29"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1c(-c2cccc([N+](=O)[O-])c2)cc(-c2ccccc2)nc1C.CCOC(C)=O.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1nc(-c2ccccc2)cc(-c2cccc([N+](=O)[O-])c2)c1CO",
        "output": "383"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CN(C)C=O.C[C@@H](O)C1CCNCC1.Cl.Clc1ccc(I)cc1.O=P([O-])([O-])[O-].[Cu]Br.[K+].[K+].[K+].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>C[C@@H](O)C1CCN(c2ccc(Cl)cc2)CC1",
        "output": "931"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)C(C)(Cc1ccc(OCCC2CN(Cc3ccc(C(F)(F)F)cc3)C(=O)N2CC)cc1)Oc1ccccc1.[Na+].[OH-]>>CCN1C(=O)N(Cc2ccc(C(F)(F)F)cc2)CC1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)O)cc1",
        "output": "192"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)Cc1ccc(F)c(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)c(C)c2C)c1.COCC(C)(C)C.COCCOC.[Na+].[OH-]>>Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)Nc2cc(CC(=O)O)ccc2F)c1C",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)CCCCOc1ccc2cccc(CCNC(C)=O)c2c1.Cl.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(=O)NCCc1cccc2ccc(OCCCCCO)cc12",
        "output": "343"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCn1c(=O)c2c(n1CC(=O)O)CCCC2.NC(=O)c1cc(-c2cccnc2[C@@H](N)Cc2cc(F)cc(F)c2)ccc1F.O=C(O)C(F)(F)F>>CCn1c(=O)c2c(n1CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)c1ncccc1-c1ccc(F)c(C(N)=O)c1)CCCC2",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CI.CN(C)C=O.O=C(O)C1(c2ccc(Br)cc2)CC1.O=C([O-])[O-].[K+].[K+]>>COC(=O)C1(c2ccc(Br)cc2)CC1",
        "output": "415"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CO.OC1CCN(c2ccccc2)C12CCN(Cc1ccccc1)CC2.[Pd]>>OC1CCN(c2ccccc2)C12CCNCC2",
        "output": "84"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.Cc1ccc(S(=O)(=O)[O-])cc1.Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CC1(CC2)OCCO1.O.c1cc[nH+]cc1>>CC(C)=Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CC1(CC2)OCCO1",
        "output": "285"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC(CCc2noc3c(CO)c(O)ccc23)CC1.CN(C)C=O.Cc1ccc(S(=O)(=O)OCC2CCOC2)cc1.O.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CC(C)(C)OC(=O)N1CCC(CCc2noc3c(CO)c(OCC4CCOC4)ccc23)CC1",
        "output": "438"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOc1ccc(C2=NCC(O)C(c3ccccc3)O2)cc1.ClCCCl.O=C=Nc1ccccc1>>CCOc1ccc(C2=NCC(OC(=O)Nc3ccccc3)C(c3ccccc3)O2)cc1",
        "output": "34"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C.CCCc1ccc(Oc2cccnc2[N+](=O)[O-])c(OC)c1.CO.NN.O>>CCCc1ccc(Oc2cccnc2N)c(OC)c1",
        "output": "457"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.C1COCCO1.CC(=O)[O-].CC(=O)[O-].CCOC(C)=O.O=C(Nc1cc2ccc(Br)cc2cn1)C1CC1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>O=C(Nc1cc2ccc(N3CCCCC3)cc2cn1)C1CC1",
        "output": "294"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Clc1cc(Cl)ncn1.OC1CCCCC1O.[Cl-].[H-].[NH4+].[Na+]>>OC1CCCCC1Oc1cc(Cl)ncn1",
        "output": "653"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)C(=O)OCOC(=O)[C@@H](Cc1ccccc1)C[C@H](Cc1ccccc1)C(=O)Cl.CCN(CC)CC.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.NCCC(=O)OCc1ccccc1>>CC(C)(C)C(=O)OCOC(=O)[C@@H](Cc1ccccc1)C[C@H](Cc1ccccc1)C(=O)NCCC(=O)OCc1ccccc1",
        "output": "45"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C/C(=C(\\F)CO)c1cc2c(c(Br)c1OC(C)C)C(C)(C)CC=C2C(C)C.CC#N.CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.ClCCl>>C/C(=C(\\F)C=O)c1cc2c(c(Br)c1OC(C)C)C(C)(C)CC=C2C(C)C",
        "output": "183"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CC2CC(=O)CC2C1.ClCCl.O=C(O)C(F)(F)F>>O=C1CC2CNCC2C1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)OC(=O)C=C(CC(O)(C#Cc2ccc(C3(C#N)CC3)c(F)c2)C2CCCC2)O1.CCO.[OH-].[OH-].[Pd+2]>>CC1(C)OC(=O)C=C(CC(O)(CCc2ccc(C3(C#N)CC3)c(F)c2)C2CCCC2)O1",
        "output": "717"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NC1CCCc2ccc(-c3cccc(C(F)(F)F)c3)nc21.O=C(O)c1cnccn1>>O=C(NC1CCCc2ccc(-c3cccc(C(F)(F)F)c3)nc21)c1cnccn1",
        "output": "697"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc2c(C)nc(OC(=O)N3CCN(C(=O)OC(C)(C)C)CC3)c([N+](=O)[O-])c2cc1OC.O=C(O)C(F)(F)F.[Na+].[OH-]>>COc1cc2c(C)nc(OC(=O)N3CCNCC3)c([N+](=O)[O-])c2cc1OC",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)c1cnc2c(c(C)nn2C)c1NCS(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1.[K+].[OH-]>>Cc1nn(C)c2ncc(C(=O)O)c(NCS(=O)(=O)c3ccc(Oc4ccc(Cl)cc4)cc3)c12",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "NC1(CO)CC1.O=C(O)c1cc(OCC2CC2)c(N2CC(F)(F)C2)cn1>>O=C(NC1(CO)CC1)c1cc(OCC2CC2)c(N2CC(F)(F)C2)cn1",
        "output": "137"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C)OB(c2cn[nH]c2)OC1(C)C.CN(C)C=O.COCCBr.O=C([O-])[O-].[Cs+].[Cs+]>>COCCn1cc(B2OC(C)(C)C(C)(C)O2)cn1",
        "output": "577"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "NCCCOc1cccc(C2=NNC(=O)CC2)c1.c1cc(OCC2CO2)ccc1CCOCC1CC1>>O=C1CCC(c2cccc(OCCCNCC(O)COc3ccc(CCOCC4CC4)cc3)c2)=NN1",
        "output": "16"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC[SiH](CC)CC.CN1C(=O)Cc2cc(C(=O)CCl)ccc21.O.O=C(O)C(F)(F)F>>CN1C(=O)Cc2cc(CCCl)ccc21",
        "output": "92"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.Cc1ccc(NC2CCN(C(=O)OC(C)(C)C)CC2)c([N+](=O)[O-])c1.[Pd]>>Cc1ccc(NC2CCN(C(=O)OC(C)(C)C)CC2)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.NC1CCOCC1.O=C(Cl)c1ccc(I)cc1>>O=C(NC1CCOCC1)c1ccc(I)cc1",
        "output": "271"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#Cc1ccc(-c2ccc(Cl)cc2)cn1.CN(C)C1CCN(c2ccc(I)cn2)C1>>CN(C)C1CCN(c2ccc(C#Cc3ccc(-c4ccc(Cl)cc4)cn3)cn2)C1",
        "output": "819"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCN.ClCCl.O=C(Cl)COc1ccccc1>>CCCCNC(=O)COc1ccccc1",
        "output": "45"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2ccccc2)nc1.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>OCc1ccc(-c2ccccc2)nc1",
        "output": "522"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C12C(=O)Nc1cc(Cl)ccc12.CCN(C(C)C)C(C)C.COc1cc(S(=O)(=O)N2CCOCC2)ccc1N.O=C(O)C(F)(F)F.O=P(Cl)(c1ccccc1)c1ccccc1>>COc1cc(S(=O)(=O)N2CCOCC2)ccc1NC(=O)C1NC(CC(C)(C)C)C2(C(=O)Nc3cc(Cl)ccc32)C1c1cccc(Cl)c1F",
        "output": "563"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NC1CCC(N2CCCC2)CC1.ClCCl.O=C(O)C(F)(F)F>>NC1CCC(N2CCCC2)CC1",
        "output": "538"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1nc(CNC(=O)C(C)(C)C)ccc1Cl.CO.O.[Na+].[OH-]>>CC(C)(C)C(=O)NCc1ccc(Cl)c(C(=O)O)n1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)OC(=O)Nc2ccc(OCCCCl)cc21.Sc1ccc(C2CCCCC2)cc1>>CC1(C)OC(=O)Nc2ccc(OCCCSc3ccc(C4CCCCC4)cc3)cc21",
        "output": "460"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.COc1ccc(-c2ccc(C(=O)O)cc2)cc1OC1CCCC1.Cc1ccccc1.Cl.ClCCl.NO.O=C(Cl)C(=O)Cl>>COc1ccc(-c2ccc(C(=O)NO)cc2)cc1OC1CCCC1",
        "output": "741"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C(C)(NC(=O)c1cc(OCC(F)(F)F)c(C2CC2)cn1)c1noc(C)n1.CO.N>>Cc1nc(C(C)(NC(=O)c2cc(OCC(F)(F)F)c(C3CC3)cn2)C(N)=O)no1",
        "output": "163"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.O=[Cr](=O)([O-])Cl.OCCCOCc1ccccc1.c1cc[nH+]cc1>>O=CCCOCc1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)n1nc(-c2ccc(Cl)nc2-c2ccccc2)ccc1=O.NN.O>>CC(C)n1nc(-c2ccc(NN)nc2-c2ccccc2)ccc1=O",
        "output": "417"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)O.ClCCl.O=C1C=CC(=O)N1CCCO>>O=CCCN1C(=O)C=CC1=O",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[O-].CS(C)=O.Cc1ccnc2nc(Cl)[nH]c(=O)c12.Cl.OCCCCCc1ccccc1.[K+]>>Cc1ccnc2nc(OCCCCCc3ccccc3)[nH]c(=O)c12",
        "output": "37"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CS(C)=O.N#Cc1ccc(Cl)cc1[N+](=O)[O-]>>N#Cc1ccc(N2CCOCC2)cc1[N+](=O)[O-]",
        "output": "105"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOCC.Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCN(C(=O)OC(C)(C)C)CC2(C)C)cc1.Cl.ClCCl>>Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCNCC2(C)C)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCCCCCCCCCOC(CO)COC(c1ccccc1)(c1ccccc1)c1ccccc1.CCOCC.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>CCCCCCCCCCCCCCCCCCOC(COC(c1ccccc1)(c1ccccc1)c1ccccc1)COS(=O)(=O)c1ccc(C)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)Nc2cc(Oc3ccc4c(c3)c(Cl)cn4C(=O)Nc3ccccc3)ccn2)CC1.O.O=C(O)C(F)(F)F.O=C([O-])O.[Na+].[Na+].[OH-]>>O=C(Nc1cc(Oc2ccc3c(c2)c(Cl)cn3C(=O)Nc2ccccc2)ccn1)C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CI.CN(C)C=O.Cc1ccc(C(=O)O)cc1Oc1ccnc(Cl)c1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(C)c(Oc2ccnc(Cl)c2)c1",
        "output": "415"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1cc2cc(Oc3ccc(C(C)(C)C)cc3)ccc2cn1.OCC1CCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)[C@H](Cc1ccc(OCC2CCCC2)cc1)NC(=O)c1cc2cc(Oc3ccc(C(C)(C)C)cc3)ccc2cn1",
        "output": "478"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)[N-]C(C)C.CN(C)C=O.Fc1ccc(F)c(Br)c1.[Cl-].[Li+].[NH4+]>>O=Cc1c(F)ccc(F)c1Br",
        "output": "239"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.C[C@@H]1CNCCN1.Clc1ncc(Cl)c(Cl)n1.O=C([O-])[O-].[K+].[K+]>>C[C@@H]1CN(c2nc(Cl)ncc2Cl)CCN1",
        "output": "296"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.Cn1c(=O)cnn(-c2cc(Oc3ccc([N+](=O)[O-])cc3)c(Cl)cc2F)c1=O.O.[Fe]>>Cn1c(=O)cnn(-c2cc(Oc3ccc(N)cc3)c(Cl)cc2F)c1=O",
        "output": "335"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O.Cc1ccc(-c2ccccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1.Cc1noc(C)c1S(N)(=O)=O.O=C(c1ncc[nH]1)c1ncc[nH]1>>Cc1noc(C)c1S(=O)(=O)NC(=O)c1cccc(-n2c(C)ccc2-c2ccccc2OCc2ccccc2)c1",
        "output": "579"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCCCC(=O)O.CN1CCOCC1.COc1nnnc(OC)c1Cl.Cc1ccc(S(=O)(=O)O)cc1.NCCC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)NCCCC(=O)NCCC(=O)OCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCO.COC(=O)c1ccc(CN(C)c2nc(-c3ccc([N+](=O)[O-])cc3)cs2)cc1.[C].[Pd]>>COC(=O)c1ccc(CN(C)c2nc(-c3ccc(N)cc3)cs2)cc1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.NOCC1CC1.O=C(O)c1cc2c(ncn2CCC(=O)N2CCCC2)c(F)c1Nc1ccc(Br)cc1Cl>>O=C(NOCC1CC1)c1cc2c(ncn2CCC(=O)N2CCCC2)c(F)c1Nc1ccc(Br)cc1Cl",
        "output": "741"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOCC.CO.FB(F)F.Nc1c(C(=O)O)cccc1[N+](=O)[O-].[BH4-].[Na+]>>Nc1c(CO)cccc1[N+](=O)[O-]",
        "output": "72"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CNC1.CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1Cl.CCN(C(C)C)C(C)C.CS(C)=O>>CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1N1CCC1",
        "output": "505"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)c1cccc(CC#N)c1.O.O=C(O)C(F)(F)F.[BH4-].[Na+]>>COC(=O)c1cccc(CCN)c1",
        "output": "246"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.NC(=O)c1cc(Cl)ccc1OCc1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCc1cc(Cl)ccc1OCc1ccccc1",
        "output": "215"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.OC[C@@H]1CCCCO1>>O=S(=O)(OC[C@@H]1CCCCO1)C(F)(F)F",
        "output": "582"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)O.CSCC[C@@H](N)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NC1C2CC3CC(C2)CC1C3.Cl.ClCCl.O>>CSCC[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NC1C2CC3CC(C2)CC1C3",
        "output": "133"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CCN(CC)CC.CCOC(=O)c1ccc(Cl)nc1.CCOc1ccccc1O[C@@H]1CCCNC1.O>>CCOC(=O)c1ccc(N2CCC[C@@H](Oc3ccccc3OCC)C2)nc1",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.CCOC(=O)c1sc(-c2ccc(OCC(C)C)c(C#N)c2)nc1C.Cl.[Na+].[OH-]>>Cc1nc(-c2ccc(OCC(C)C)c(C#N)c2)sc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC/C(=C\\CCC(O)(CC)CC)c1cc(Br)cs1.CCN(CC)CC.CC[Si](CC)(CC)OS(=O)(=O)C(F)(F)F.CN(C)c1ccccn1.ClCCl.O>>CC/C(=C\\CCC(CC)(CC)O[Si](CC)(CC)CC)c1cc(Br)cs1",
        "output": "839"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)N.CCN(CC)CC.COc1ccc(S(=O)(=O)Cl)cc1Br.ClCCl.O=C(O)CC(O)(CC(=O)O)C(=O)O>>COc1ccc(S(=O)(=O)NC(C)(C)C)cc1Br",
        "output": "43"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCCBr.Sc1ccccc1Br>>ClCCCSc1ccccc1Br",
        "output": "124"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1c(Cl)c(C(C)(C)C)nn1C.CO.[Na+].[OH-]>>Cn1nc(C(C)(C)C)c(Cl)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1[nH]c(Cl)c(C)c1Cl.Cl.O.O>>Cc1c(Cl)[nH]c(C(=O)O)c1Cl",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(CC(=O)O)cc1.NCC1CN(Cc2ccc(Cl)c(Cl)c2)CCO1>>COc1ccc(CC(=O)NCC2CN(Cc3ccc(Cl)c(Cl)c3)CCO2)cc1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCC.COC(=O)[C@H]1[C@H](C(=O)OC)C1(Br)CO.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>COC(=O)[C@H]1[C@H](C(=O)OC)C1(Br)C=O",
        "output": "142"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccccc1.Nc1cccc(Br)c1C(=O)O.O=C(Cl)CCl.c1ccncc1>>O=C(CCl)Nc1cccc(Br)c1C(=O)O",
        "output": "9"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)CCCCCCCCN1C(=O)C(c2ccccc2)N(c2ccccc2)C1=O.Cl>>O=C(O)CCCCCCCCN1C(=O)C(c2ccccc2)N(c2ccccc2)C1=O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrBr.CCC(=O)c1ccc(Cl)cc1Cl.CO>>CC(Br)C(=O)c1ccc(Cl)cc1Cl",
        "output": "82"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C(C)(C)Oc1ccc(CCN)cc1.O=C(O)c1cnc(-c2ccc(C(F)(F)F)cc2)nc1C1CC1>>CCOC(=O)C(C)(C)Oc1ccc(CCNC(=O)c2cnc(-c3ccc(C(F)(F)F)cc3)nc2C2CC2)cc1",
        "output": "737"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Cc1noc(C)c1-c1c(C#C[Si](C)(C)C)cc(C(F)(F)F)cc1-c1ccc(O)cc1>>C#Cc1cc(C(F)(F)F)cc(-c2ccc(O)cc2)c1-c1c(C)noc1C",
        "output": "337"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc2c(c1)CC2.CC(C)(C)[O-].Cc1ccccc1.Nc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Fe+2].[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>c1ccc(Nc2ccc3c(c2)CC3)cc1",
        "output": "405"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(OCC)[C@H](C)N(Cc1cccc2cccnc12)C(=O)[C@H](C)N.CN(CC(=O)O)NC(=O)NCc1ccncc1>>CCOC(OCC)[C@H](C)N(Cc1cccc2cccnc12)C(=O)[C@H](C)NC(=O)CN(C)NC(=O)NCc1ccncc1",
        "output": "133"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)c1ccc(OCC(=O)c2ccc3c(c2)C(C)(C)CCC3(C)C)cc1.CS(C)=O.O.[K+].[OH-]>>CC1(C)CCC(C)(C)c2cc(C(=O)COc3ccc(C(=O)O)cc3)ccc21",
        "output": "386"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1cc(-c2cccc(C#N)c2)n(-c2cccc(C#N)c2)n1.O=C(O)c1cc(-c2cc(F)cc(Cl)c2)n(-c2ccc(F)c(Cl)c2)n1>>N#Cc1cccc(-c2cc(C(=O)O)nn2-c2cccc(C#N)c2)c1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)C[AlH]CC(C)C.COC(=O)Cc1ccc(Cc2nc(C3CCCC3)nc3c2S(=O)(=O)CCC3)cc1>>O=S1(=O)CCCc2nc(C3CCCC3)nc(Cc3ccc(CCO)cc3)c21",
        "output": "343"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CC(=O)Cl.CCN(CC)CC.CN1CCCC1=O.ClCCl.Nc1cccc(Nc2cc(Nc3cccc(Oc4ccccc4)c3)ncn2)c1>>C=CC(=O)Nc1cccc(Nc2cc(Nc3cccc(Oc4ccccc4)c3)ncn2)c1",
        "output": "10"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC1(C)OB(c2ccc3[nH]ccc3c2)OC1(C)C.CCI.[H-].[Na+]>>CCn1ccc2cc(B3OC(C)(C)C(C)(C)O3)ccc21",
        "output": "302"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1ncnc2c1c(-c1cccc(OCC34CCC(CC3)O4)c1)cn2C1CCNCC1.O=C1COC1>>Nc1ncnc2c1c(-c1cccc(OCC34CCC(CC3)O4)c1)cn2C1CCN(C2COC2)CC1",
        "output": "983"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)C(C(C)C)N1CC(Cc2nc3c(N4CCOCC4)nc(-n4c(C)nc5ccccc54)nc3n2C)C1.Cl.O.[Li+].[OH-]>>Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CN(C(C(=O)O)C(C)C)C3)n(C)c2n1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)c1cc(C(C)C)c(-c2ccccc2P2C(C)(C)CC(=O)CC2(C)C)c(C(C)C)c1.Cc1ccc(S(=O)(=O)O)cc1.O.OCCO>>CC(C)c1cc(C(C)C)c(-c2ccccc2P2C(C)(C)CC3(CC2(C)C)OCCO3)c(C(C)C)c1",
        "output": "265"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O.O=C(Cl)c1ccccc1.O=[N+]([O-])c1cnc(N2CCC(O)CC2)c(Cl)c1.c1ccncc1>>O=C(OC1CCN(c2ncc([N+](=O)[O-])cc2Cl)CC1)c1ccccc1",
        "output": "51"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(C(=O)O)ccn34)c12.CN.CN(C)C=O.O=C(n1ccnc1)n1ccnc1>>CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(C(=O)NC)ccn34)c12",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.CN(Cc1ccccc1)C1CNCC(C(=O)Nc2ccc(Cl)cc2)C1.Cl.Cl.ClCCl.O=C(O)c1cccc(-c2ccco2)c1>>CN(Cc1ccccc1)C1CC(C(=O)Nc2ccc(Cl)cc2)CN(C(=O)c2cccc(-c3ccco3)c2)C1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.ClCCl.[Na+].[OH-].c1ccc2c(c1)NCCCO2>>CC(C)(C)OC(=O)N1CCCOc2ccccc21",
        "output": "827"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CNC.O=Cc1ccc(NC(=O)c2cc(N(CC3CC3)C3CCCCC3)ncn2)cc1>>CN(C)Cc1ccc(NC(=O)c2cc(N(CC3CC3)C3CCCCC3)ncn2)cc1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)NC(C)C.CN(C)C=O.CN1CCNCC1.COC(=O)c1ccc(Cl)nc1.O.[I-].[Na+]>>COC(=O)c1ccc(N2CCN(C)CC2)nc1",
        "output": "220"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNCC1.CC(=O)O.CCO.Cc1ccc2c(c1)CC(=O)N2.O=Cc1[nH]c2c(c1CCC(=O)O)CCCC2>>Cc1ccc2c(c1)C(=Cc1[nH]c3c(c1CCC(=O)O)CCCC3)C(=O)N2",
        "output": "440"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.Nc1cc(N2CCOCC2)ncc1[N+](=O)[O-].[Pd]>>Nc1cnc(N2CCOCC2)cc1N",
        "output": "269"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COc1ncccc1C(=O)O.O=C([O-])O.O=S(=O)(O)O.[Na+]>>COC(=O)c1cccnc1OC",
        "output": "521"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCCn2c1cc(Cl)nc2=O.OCc1ccc(Oc2ccc(F)cc2)c(F)c1>>CN1CCCn2c1cc(OCc1ccc(Oc3ccc(F)cc3)c(F)c1)nc2=O",
        "output": "653"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)Oc1ccc(C(=O)O)cn1.CC(C)=O.CCOC(C)=O.CI.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(OC(C)(C)C)nc1",
        "output": "415"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc2cc(N)ccc2[nH]1.Cc1cccc(-c2cc3nccc(Cl)c3s2)n1>>Cc1cccc(-c2cc3nccc(Nc4ccc5[nH]c(C)cc5c4)c3s2)n1",
        "output": "927"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCC.Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)NC3CN(C(=O)OC(C)(C)C)CC3C(F)(F)F)n2c1.Cl.O=C(O)C(F)(F)F>>Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)NC3CNCC3C(F)(F)F)n2c1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.ClCCCl.Clc1ccc2c(c1Nc1ccnc3[nH]c4c(c13)CNCC4)OCO2.O=C(Cl)C1CCC1>>O=C(C1CCC1)N1CCc2[nH]c3nccc(Nc4c(Cl)ccc5c4OCO5)c3c2C1",
        "output": "125"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc2sc3c(c2c1)CCCNC3.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CO>>CC(C)(C)OC(=O)N1CCCc2c(sc3ccc(Br)cc23)C1",
        "output": "694"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.COc1cc(C#N)nc(N)n1.[Pd]>>COc1cc(CN)nc(N)n1",
        "output": "205"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1ncc2nc(N(C)c3ccccc3)sc2c1O.CO.C[O-].NCC(=O)O.[Na+]>>CN(c1ccccc1)c1nc2cnc(C(=O)NCC(=O)O)c(O)c2s1",
        "output": "977"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)NC1CCNC1.CN1CCCC1=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[K+].[K+]>>CC(=O)NC1CCN(c2ccc([N+](=O)[O-])cc2)C1",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)Cc1csc(NC(=O)OC(C)(C)C)n1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Li+].[OH-]>>CC(C)(C)OC(=O)Nc1nc(CC(=O)O)cs1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C[C@@H]1NC[C@H](c2ccccc2F)NC1=O.CC(C)C[C@H]1CN(C(=O)[C@@H]2C[C@H]2c2ccccc2)[C@@H](CC(C)C)C(=O)N1.O=C(O)[C@@H]1C[C@H]1c1ccccc1>>CC(C)C[C@H]1C(=O)N[C@@H](c2ccccc2F)CN1C(=O)[C@@H]1C[C@H]1c1ccccc1",
        "output": "297"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)c1ccc(NCCCc2ccccc2)cc1NC(=O)c1ccccc1.O=C(O)C(F)(F)F>>O=C(Nc1cc(NCCCc2ccccc2)ccc1C(=O)O)c1ccccc1",
        "output": "752"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COC(=O)c1cc(-c2ccccc2)nc2c1[nH]c1cccc(OCc3ccccc3)c12.O=C[O-].[NH4+].[Pd]>>COC(=O)c1cc(-c2ccccc2)nc2c1[nH]c1cccc(O)c12",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=C(C)CN(CCO)C(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)Cl)cc1>>C=C(C)CN(CCOS(=O)(=O)c1ccc(C)cc1)C(=O)OC(C)(C)C",
        "output": "197"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)CC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.COC(=O)c1ccc(F)c(-c2c(F)cc(O)cc2F)n1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1ccc(F)c(-c2c(F)cc(OC3CCN(C(=O)OC(C)(C)C)CC3)cc2F)n1",
        "output": "846"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=O.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(C3CNCC(C(=O)OC)C3)cc12.O=CO>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(C3CC(C(=O)OC)CN(C)C3)cc12",
        "output": "217"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCO.CN(c1ccc(-c2ccccc2-c2nnn[nH]2)cc1[N+](=O)[O-])C1CCCC1.Cl.[Pd]>>CN(c1ccc(-c2ccccc2-c2nnn[nH]2)cc1N)C1CCCC1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(OCc4ccccc4)cc3)ncn2)c1Cl.[Pd]>>COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(O)cc3)ncn2)c1Cl",
        "output": "698"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COC(=O)c1nc([C@@H](Cc2ccc3ccccc3c2)NC(=O)OC(C)(C)C)sc1-c1ccccc1.[Li+].[OH-]>>CC(C)(C)OC(=O)N[C@H](Cc1ccc2ccccc2c1)c1nc(C(=O)O)c(-c2ccccc2)s1",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+].[N-]=[N+]=NCc1n[nH]c2ccc(Cl)cc12>>NCc1n[nH]c2ccc(Cl)cc12",
        "output": "89"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(N)c1nccs1.O=C(O)c1ccc(C2CC2)c(OCC2CC2)n1>>CC(C)(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1nccs1",
        "output": "137"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.CN(CCO)c1ccc(N)cn1.O=C(Cl)Oc1ccccc1>>CN(CCO)c1ccc(NC(=O)Oc2ccccc2)cn1",
        "output": "763"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)C1CC1OCC.CO.O.[Li+].[OH-]>>CCOC1CC1C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.COc1ccc(Nc2nc(-c3cccc(C(=O)O)c3)nc3scnc23)cc1OC.ClCCl.Cn1ccnc1.Nc1ccc2[nH]ncc2c1>>COc1ccc(Nc2nc(-c3cccc(C(=O)Nc4ccc5[nH]ncc5c4)c3)nc3scnc23)cc1OC",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC1(C)CCCC(C)(C)N1.CN(C)C=O.Fc1ccc(Br)cc1F.[Li]CCCC>>O=Cc1c(Br)ccc(F)c1F",
        "output": "239"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C(=O)O)c1ccc(Cl)cc1.CC(C)C(=O)Nc1cc(C2CCN(CCCN)CC2)ccc1F>>CC(C)C(=O)Nc1cc(C2CCN(CCCNC(=O)C(C)(C)c3ccc(Cl)cc3)CC2)ccc1F",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.Cn1ccc2ncnc(Oc3ccc(N)c(Cl)c3)c21.O.O=C=Nc1ccc2ccccc2c1>>Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4ccc5ccccc5c4)c(Cl)c3)c21",
        "output": "912"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cccc(Br)n1.OB(O)c1cc(Br)ccc1F>>CCOC(=O)c1cccc(-c2cc(Br)ccc2F)n1",
        "output": "869"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)c1ccncc1.COc1ccc(N2CCN[C@@H](Cc3ccccc3)C2)cc1OC1CCCC1.C[C@H](O)CC(=O)O.ClCCl>>COc1ccc(N2CCN(C(=O)C[C@H](C)O)[C@@H](Cc3ccccc3)C2)cc1OC1CCCC1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1ccc(CNC[C@H](O)c2ccc(Cl)cc2)cc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O.O=C(O)c1cc(Cl)cc2cc[nH]c12>>CC(C)(C)c1ccc(CN(C[C@H](O)c2ccc(Cl)cc2)C(=O)c2cc(Cl)cc3cc[nH]c23)cc1",
        "output": "893"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COc1c([N+](=O)[O-])ccc2c1CCCC(N1CCOCC1)C2.[Pd]>>COc1c(N)ccc2c1CCCC(N1CCOCC1)C2",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrBr.O=S(=O)(O)O.O=S(=O)([O-])[O-].O=[N+]([O-])c1ccc(Cl)cc1F.[Ag+2]>>O=[N+]([O-])c1cc(Br)c(Cl)cc1F",
        "output": "98"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.COC(=O)c1ccc(NS(C)(=O)=O)c2occc12.[H-]>>CS(=O)(=O)Nc1ccc(CO)c2ccoc12",
        "output": "444"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=[N+]=[N-].CN(CC(=O)O)S(=O)(=O)c1ccc(Cl)cc1>>COC(=O)CN(C)S(=O)(=O)c1ccc(Cl)cc1",
        "output": "60"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.Cl.Cl.ClCCl.N[C@H]1CCN(Cc2ccccc2)C[C@H]1O.O=C(Cl)OCCCl>>O=C(N[C@H]1CCN(Cc2ccccc2)C[C@H]1O)OCCCl",
        "output": "94"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1cc(C(C)=O)[nH]n1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.O.[Br-].[Br-].[Br-]>>CCOC(=O)c1cc(C(=O)CBr)[nH]n1",
        "output": "360"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(C)=O.C[Mg]Br.Cl.O=Cc1cc(Br)cc(C(=O)O)c1O>>CC(O)c1cc(Br)cc(C(=O)O)c1O",
        "output": "787"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br.COc1cc([N+](=O)[O-])c(C)cc1N.O.O=N[O-].[Na+]>>COc1cc([N+](=O)[O-])c(C)cc1Br",
        "output": "373"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1ccc2c(C(=O)O)c(C)sc2c1.ClCCl>>Cc1sc2cc(O)ccc2c1C(=O)O",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)c1cnc(Cl)c(OC)c1.Cl.[Na+].[OH-]>>COc1cc(C(=O)O)cnc1Cl",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCN=C=NCCCN(C)C.Cl.NC(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(Oc2ccccc2)cc1.O.O=C(O)c1ccc(F)c2ccccc12.On1nnc2ccccc21>>O=C(NC(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(Oc2ccccc2)cc1)c1ccc(F)c2ccccc12",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCCCCCCl.O=C1CCNCC1>>CCOCCCCCN1CCC(=O)CC1",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN=C=NCCCN(C)C.Cl.ClCCCl.N#Cc1ccc(N(CC(=O)O)CC(F)(F)F)cc1C(F)(F)F.N=C(NO)c1cccc([N+](=O)[O-])c1>>N#Cc1ccc(N(Cc2nc(-c3cccc([N+](=O)[O-])c3)no2)CC(F)(F)F)cc1C(F)(F)F",
        "output": "895"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)CC(=O)Cl.CCN(CC)CC.CNCc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1noc(C)c1C.ClCCl.O=S(=O)([O-])O.[Na+]>>Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC(C)(C)C)c1C",
        "output": "240"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cccc(N2CCNCC2)c1.N#CCBr>>COc1cccc(N2CCN(CC#N)CC2)c1",
        "output": "880"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(O)ccc1-c1nc2ccc(NC(C)=O)cc2[nH]1.CS(=O)(=O)Cl>>COc1cc(OS(C)(=O)=O)ccc1-c1nc2ccc(NC(C)=O)cc2[nH]1",
        "output": "149"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN1CCNCC1.O.O=C(O)Cc1cccc(OCCCCl)c1>>CN1CCN(CCCOc2cccc(CC(=O)O)c2)CC1",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(Cc1ccc(OCC(O)c2cccc(OC)c2)cc1)OCC.CCOC(C)=O.O=C1OI(=O)(O)c2ccccc21>>CCOC(=O)C(Cc1ccc(OCC(=O)c2cccc(OC)c2)cc1)OCC",
        "output": "32"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)C(C)(C)Cn1ncc2cc(-c3noc(-c4ccc(OC(C)C)c(C#N)c4)n3)ccc21.[Na+].[OH-]>>CC(C)Oc1ccc(-c2nc(-c3ccc4c(cnn4CC(C)(C)C(=O)O)c3)no2)cc1C#N",
        "output": "281"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "NC12CC3CC(CC(C3)C1)C2.O=Cc1ccc(OCc2cccc(F)c2)cc1>>Fc1cccc(COc2ccc(CNC34CC5CC(CC(C5)C3)C4)cc2)c1",
        "output": "468"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.COc1ccc(-c2ccc3cc(OC)c(OC)cc3c2)c([N+](=O)[O-])c1.[Pd]>>COc1ccc(-c2ccc3cc(OC)c(OC)cc3c2)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.COCCO.Cc1ccccc1.Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(Cl)c(Cc3ccc(-n4cccn4)cc3)c(Cl)c2c1.[H-].[Na+]>>COCCOc1nc2ccc(C(O)(c3ccc(Cl)cc3)c3cncn3C)cc2c(Cl)c1Cc1ccc(-n2cccn2)cc1",
        "output": "433"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.CCOC(=O)C1CC(=O)C1.COC(C)(C)C.NC(=O)c1ccc[n+]([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](OP(=O)(O)O)[C@@H]3O)[C@@H](O)[C@H]2O)c1.O.O=P([O-])([O-])[O-].[Cl-].[Na+]>>CCOC(=O)C1CC(O)C1",
        "output": "91"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)OCc2ccccc2)cc1.[Pd]>>COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)O)cc1",
        "output": "186"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)Cl.Cl.Nc1ccc(Cl)cc1Cl.c1ccncc1>>CCOC(=O)Nc1ccc(Cl)cc1Cl",
        "output": "102"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1noc(-c2ccc(Br)cc2)c1-c1nnc(Cc2ccccc2)o1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4-c4nnc(Cc5ccccc5)o4)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)c1ccccn1.Nc1ccc(Cl)cc1.O.O=C(Cl)CC1CC1(F)F>>O=C(CC1CC1(F)F)Nc1ccc(Cl)cc1",
        "output": "9"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.Cc1c([N+](=O)[O-])cc(Cl)c(Cl)c1[N+](=O)[O-].[Pt]>>Cc1c(N)cc(Cl)c(Cl)c1N",
        "output": "204"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.COC(=O)[C@H]1C[C@H](N)C1.Cl.ClCCl>>COC(=O)[C@@H]1C[C@@H](NC(=O)OC(C)(C)C)C1",
        "output": "631"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1nccc(Nc2cc(Br)cn(C)c2=O)n1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[K+].[Pd].[Pd]>>Cc1nccc(Nc2cc(B3OC(C)(C)C(C)(C)O3)cn(C)c2=O)n1",
        "output": "943"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1c(Cl)c(C)c(C(C)=O)c(OCCBr)c1OCCC(C)c1ccc(F)cc1.Cl.FC1(F)CCNCC1>>COc1c(Cl)c(C)c(C(C)=O)c(OCCN2CCC(F)(F)CC2)c1OCCC(C)c1ccc(F)cc1",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCc1nc2ccccc2n1CCO.ClC(Cl)Cl.O=S(Cl)Cl>>CCc1nc2ccccc2n1CCCl",
        "output": "96"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.N.N#Cc1cccc(-n2cnc3cnc4ccc(Cl)cc4c32)c1.[Ni]>>NCc1cccc(-n2cnc3cnc4ccc(Cl)cc4c32)c1",
        "output": "175"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCCNc1nc(Cl)nc(C)c1C#CCCCN1C(=O)c2ccccc2C1=O.CCOC(C)=O.N#Cc1ccc(N)cc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>CCCNc1nc(Nc2ccc(C#N)cc2)nc(C)c1C#CCCCN1C(=O)c2ccccc2C1=O",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.Nc1ccc(-n2cccc2)cc1.O=C=Nc1ccc(Cl)cc1>>O=C(Nc1ccc(Cl)cc1)Nc1ccc(-n2cccc2)cc1",
        "output": "473"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1cccc(C(=O)OC)n1.[K+].[OH-]>>COC(=O)c1cccc(C(=O)O)n1",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cc1nn(C)cc1CN1CCC(c2ccc(C(=O)Nc3ccccc3NC(=O)OC(C)(C)C)cc2)CC1.Cl.O.[Na+].[OH-]>>Cc1nn(C)cc1CN1CCC(c2ccc(C(=O)Nc3ccccc3N)cc2)CC1",
        "output": "782"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCn1ncc2c(NC3CCN(C(N)=O)CC3)c(C(=O)O)cnc21.Cc1cccc(C(N)CCC(=O)N(C)C)c1.Cl>>CCn1ncc2c(NC3CCN(C(N)=O)CC3)c(C(=O)NC(CCC(=O)N(C)C)c3cccc(C)c3)cnc21",
        "output": "790"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CN(C(=O)OC(C)(C)C)c1cccc(-n2c(=O)n(-c3ccc(C(=O)O)cc3)c3c(N)ncnc32)c1.Nc1ccccn1.O=P(Cl)(Cl)Cl.c1ccncc1>>CN(C(=O)OC(C)(C)C)c1cccc(-n2c(=O)n(-c3ccc(C(=O)Nc4ccccn4)cc3)c3c(N)ncnc32)c1",
        "output": "744"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(OC)OC.O=C(O)c1cccc([N+](=O)[O-])c1C(=O)O.O=S(=O)(O)O>>COC(=O)c1cccc([N+](=O)[O-])c1C(=O)O",
        "output": "195"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClC(Cl)Cl.N#Cc1c(Cc2ccccc2)nn(C2CCCC2)c1N.O=C(Cl)Cc1ccccc1.c1ccncc1>>N#Cc1c(Cc2ccccc2)nn(C2CCCC2)c1NC(=O)Cc1ccccc1",
        "output": "527"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)C(C)(C)Oc1ccc(C)c(OCOC)c1.Cl>>CCOC(=O)C(C)(C)Oc1ccc(C)c(O)c1",
        "output": "755"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1nc2c(C(F)(F)F)cccc2nc1-c1cc(Oc2cccc(S(=O)(=O)CCCO)c2)ccc1Cl.ClCCl>>Cc1nc2c(C(F)(F)F)cccc2nc1-c1cc(Oc2cccc(S(=O)(=O)CCCOS(C)(=O)=O)c2)ccc1Cl",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.COC1(C)CCc2c(C)c(O)c(C)c(C)c2O1.c1ccncc1>>COC1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1",
        "output": "46"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)c1cc(Cl)c(OCc2ccccc2)cc1OCc1ccccc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.[Br-].[Br-].[Br-]>>O=C(CBr)c1cc(Cl)c(OCc2ccccc2)cc1OCc1ccccc1",
        "output": "360"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1c[nH]c(-c2ccc(Cl)cc2)c1C.CI.[H-].[Na+]>>CCOC(=O)c1cn(C)c(-c2ccc(Cl)cc2)c1C",
        "output": "191"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(CO)ccc1-2.ClCCl>>CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C=O)ccc1-2",
        "output": "179"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Nc1c(C(=O)OCc2ccccc2)c(=O)[nH]c2ccccc12.[Pd]>>Nc1c(C(=O)O)c(=O)[nH]c2ccccc12",
        "output": "291"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCc1cc(Br)ccc1C1C(=O)C2C3CCC(O3)C2C1=O.COCCOC.ClCCl.OB(O)c1ccc(F)cc1.[Cs+].[F-]>>CCc1cc(-c2ccc(F)cc2)ccc1C1C(=O)C2C3CCC(O3)C2C1=O",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CNC(=O)C(=NOC)c1ccccc1CO.Cl.FC(F)(F)c1cc(Cl)cnc1Cl.[H-].[Na+]>>CNC(=O)/C(=N/OC)c1ccccc1COc1ncc(Cl)cc1C(F)(F)F",
        "output": "433"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCN(CC)CC.CCOC(=O)Cl.ClCCl.O.OCC1CCNCC1>>CC(=O)N1CCC(CO)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.CC(=O)O.COc1ccc(Cc2n[nH]c3c2c(=O)n(-c2ccccc2)c2ncccc32)cc1.O>>O=c1c2c(Cc3ccc(O)cc3)n[nH]c2c2cccnc2n1-c1ccccc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClP(Cl)(Cl)(Cl)Cl.O=P(Cl)(Cl)Cl.O=[N+]([O-])c1cnccc1O>>O=[N+]([O-])c1cnccc1Cl",
        "output": "177"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=O.O=C(Cn1c(=O)sc2ccc(Cl)cc21)N1CCC(O)CC1.c1ccncc1>>CCNC(=O)OC1CCN(C(=O)Cn2c(=O)sc3ccc(Cl)cc32)CC1",
        "output": "235"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)c1cc2ccc(C(C)F)nc2nc1C(F)(F)F.Cl.O.O.[Li+].[OH-]>>CC(F)c1ccc2cc(C(=O)O)c(C(F)(F)F)nc2n1",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)c1c(C)nc(C(F)(F)F)nc1C.O.[K+].[OH-]>>Cc1nc(C(F)(F)F)nc(C)c1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COc1cc(CC(=O)O)ccc1OC(F)F.O=S(=O)(O)O>>CCOC(=O)Cc1ccc(OC(F)F)c(OC)c1",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.CCOC(C)=O.COc1ccc2c(c1)c(CC(N)=O)c(C1CC1)n2Cc1ccccc1.ClCCl.ClCCl.O>>NC(=O)Cc1c(C2CC2)n(Cc2ccccc2)c2ccc(O)cc12",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.CN(C)C=O.COc1ccc(N2CCNCC2)c2sc(NC(=O)c3ccc(C)s3)nc12.c1ccncc1>>COc1ccc(N2CCN(C(C)=O)CC2)c2sc(NC(=O)c3ccc(C)s3)nc12",
        "output": "125"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1c([C@@H](O)CN2CCCC2CN)ccc2c1COC2=O.Cl.O=S(=O)(Cl)c1ccc(-n2cnnn2)cc1>>Cc1c([C@@H](O)CN2CCCC2CNS(=O)(=O)c2ccc(-n3cnnn3)cc2)ccc2c1COC2=O",
        "output": "43"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrBr.Cc1ccc(F)c(F)c1.ClCCl.[Fe]>>Cc1cc(F)c(F)cc1Br",
        "output": "98"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)CC(c1ccccc1)N1CN(c2ccccc2)C2(CCN(CCCn3c(=O)[nH]c4ccccc43)CC2)C1=O.O.O.[Li+].[OH-]>>O=C(O)CC(c1ccccc1)N1CN(c2ccccc2)C2(CCN(CCCn3c(=O)[nH]c4ccccc43)CC2)C1=O",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.COc1ccc(C[C@H](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)O)c(C)c1C.c1c[nH]cn1>>COc1ccc(C[C@H](C[C@H](O[Si](C)(C)C(C)(C)C)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)O)c(C)c1C",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCC2=NCCCN2CC1.CCCCc1nn(-c2cc([N+](=O)[O-])ccc2C(F)(F)F)c(C#N)c1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1F.O=C(O)c1ccccc1Cl.c1c[n-]cn1>>CCCCc1nn(-c2cc([N+](=O)[O-])ccc2C(F)(F)F)c(C#N)c1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F",
        "output": "579"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)CCC(C)(c1nc2cc(C#N)ccc2[nH]1)c1c(OC)cc(C)c2[nH]ccc12.[K+].[OH-]>>COc1cc(C)c2[nH]ccc2c1C(C)(CCC(=O)O)c1nc2cc(C#N)ccc2[nH]1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C#N)c1cccc(C(=O)O)c1.Nc1cncc(C#Cc2cnc(N)nc2)c1>>CC(C#N)c1cccc(C(=O)Nc2cncc(C#Cc3cnc(N)nc3)c2)c1",
        "output": "759"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)Cc1cc2ccc(Cl)cc2c(-c2ccc(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)cc2)c1C.O.O.[Li+].[OH-]>>Cc1c(CC(=O)O)cc2ccc(Cl)cc2c1-c1ccc(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)Cc1c(C)c(Sc2cccc3ccccc23)n2ccccc12.CO.O=C(OO)c1cccc(Cl)c1.O=C([O-])[O-].[K+].[K+]>>Cc1c(CC(=O)O)c2ccccn2c1Sc1cccc2ccccc12",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(=O)[O-].CC(=O)c1cc(Cl)c(C)c(-c2cc(F)nc(F)c2)c1-c1ccccc1.CO.[BH3-]C#N.[NH4+].[Na+]>>Cc1c(Cl)cc(C(C)N)c(-c2ccccc2)c1-c1cc(F)nc(F)c1",
        "output": "552"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NC[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)c1nc(N)sc1-c1cccc(F)c1.O=C(O)c1cccc2cnccc12>>Nc1nc(C(=O)N2[C@H](CNC(=O)c3cccc4cnccc34)C[C@@H]3C[C@@H]32)c(-c2cccc(F)c2)s1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)C1C2CC(OC3CCCCO3)CC21.Cl.[Na+].[OH-]>>O=C(O)C1C2CC(OC3CCCCO3)CC21",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.O=C(O)c1ccccc1N1CCN(S(=O)(=O)c2ccccc2Cl)CC1.O=C[O-].On1nnc2ccccc21.[NH4+]>>NC(=O)c1ccccc1N1CCN(S(=O)(=O)c2ccccc2Cl)CC1",
        "output": "358"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.O.O=P([O-])([O-])[O-].O=c1ccc2cc(S(=O)(=O)Nc3ccon3)ccc2n1-c1ccc(Cl)cc1.OB(O)c1cccc(C(F)(F)F)c1.[K+].[K+].[K+]>>O=c1ccc2cc(S(=O)(=O)Nc3ccon3)ccc2n1-c1ccc(-c2cccc(C(F)(F)F)c2)cc1",
        "output": "892"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC1(c2cccc(NS(C)(=O)=O)c2)C2CN(C(=O)CCc3cccs3)CC21.CCOC(C)=O.O.O=C([O-])O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+]>>CC1(c2cccc(NS(C)(=O)=O)c2)C2CN(CCCc3cccs3)CC21",
        "output": "112"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrC(Br)(Br)Br.CCCCCCCCCCCCSCCCO.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCCCCCCCCCCSCCCBr",
        "output": "378"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)O)ccc21.F[P-](F)(F)(F)(F)F.NCCCOCCO>>Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)NCCCOCCO)ccc21",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(Oc1ccc(C)cc1C)C(=O)O.C[C@H]1C=CC2=C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O)[C@@H]2[C@H]1CC[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CC(=O)O1>>CCC(Oc1ccc(C)cc1C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O[Si](C)(C)C(C)(C)C)CC(=O)O3)[C@H]21",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)/C=C/c1ccc(OCc2ccccc2)cc1F.[Na+].[OH-]>>O=C(O)/C=C/c1ccc(OCc2ccccc2)cc1F",
        "output": "58"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CS(=O)(=O)CC(=N)NO.Cc1ccc(C2CC(C(=O)O)CN(C(=O)N3CCOCC3)C2)cc1C(F)(F)F>>Cc1ccc(C2CC(c3nc(CS(C)(=O)=O)no3)CN(C(=O)N3CCOCC3)C2)cc1C(F)(F)F",
        "output": "924"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.ClCCl.Cn1nc2c(N)nc3c(c2c1CCN)CCCC3.O=C(Cl)N1CCOCC1>>Cn1nc2c(N)nc3c(c2c1CCNC(=O)N1CCOCC1)CCCC3",
        "output": "454"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)C1CN(C(=O)[C@H](Cc2ccc(-c3ncc(-c4ccc(O)cc4)cn3)cc2)NC(=O)c2ccc(C(C)(C)C)s2)C1.CC(C)CCCBr.CN(C)C=O.O=C([O-])O.O=C([O-])[O-].[Cs+].[Cs+].[Na+]>>CC(C)CCCOc1ccc(-c2cnc(-c3ccc(C[C@H](NC(=O)c4ccc(C(C)(C)C)s4)C(=O)N4CC(C(=O)OC(C)(C)C)C4)cc3)nc2)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCc1ccc(OCc2ccccc2)c(S(=O)(=O)c2ccc(F)cc2)c1.CCCC[N+](CCCC)(CCCC)CCCC.O.O.O.[F-]>>O=S(=O)(c1ccc(F)cc1)c1cc(CO)ccc1OCc1ccccc1",
        "output": "708"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(=O)(=O)Cl.OCCC#Cc1ccc(C(F)(F)F)cc1>>CS(=O)(=O)OCCC#Cc1ccc(C(F)(F)F)cc1",
        "output": "0"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.CS(=O)(=O)Cl.Cc1cc(C(=O)c2ccc(O)cc2)ccc1[N+](=O)[O-].O>>Cc1cc(C(=O)c2ccc(OS(C)(=O)=O)cc2)ccc1[N+](=O)[O-]",
        "output": "149"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.Cc1cc(N)ccc1N1CCOCC1.Clc1ncnc2ccc(I)cc12>>Cc1cc(Nc2ncnc3ccc(I)cc23)ccc1N1CCOCC1",
        "output": "352"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.COC(=O)/C=C/c1ccccc1N.C[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.O.On1nnc2ccccc21>>COC(=O)/C=C/c1ccccc1NC(=O)[C@H](C)NC(=O)OC(C)(C)C",
        "output": "365"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.C[Si](C)(C)C=[N+]=[N-].Cc1ccccc1.Cn1c(C(=O)O)ccc1S(N)(=O)=O>>COC(=O)c1ccc(S(N)(=O)=O)n1C",
        "output": "331"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.N#Cc1ccc(OCc2cccc(F)c2)cc1F.O.[Na+].[OH-]>>O=C(O)c1ccc(OCc2cccc(F)c2)cc1F",
        "output": "445"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.Nc1ccc(Oc2cccc([N+](=O)[O-])c2)cn1.O.c1ccncc1>>Cc1ccc(S(=O)(=O)Nc2ccc(Oc3cccc([N+](=O)[O-])c3)cn2)cc1",
        "output": "462"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Nc1ccc(S(N)(=O)=O)cc1.CCCCCC(=O)Cl.CCCCCC(=O)NS(=O)(=O)c1ccc(NC(C)=O)cc1.Cl.O.c1ccncc1>>CCCCCC(=O)NS(=O)(=O)c1ccc(N)cc1",
        "output": "66"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)CCCBr.CN(C)C=O.O=C([O-])[O-].Oc1ccc(Br)nc1.[K+].[K+]>>CCOC(=O)CCCOc1ccc(Br)nc1",
        "output": "608"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCC(O)c1ccc(C=O)cc1.CO.Cl.O.[BH4-].[Na+]>>CCCC(O)c1ccc(CO)cc1",
        "output": "356"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCOc1nc(N)c2nc(OC)n(CCCCCCCl)c2n1.CCCCOc1nc(N)c2nc(OC)n(CCCCCCN3CCN(C)CC3)c2n1.CCN1CCNCC1>>CCCCOc1nc(N)c2nc(OC)n(CCCCCCN3CCN(CC)CC3)c2n1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br.CC(=O)O.COc1ccc(Oc2ccccc2)c(C)c1>>Cc1cc(O)ccc1Oc1ccccc1",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[Si](C)(C)OCC1COc2c1ccnc2Nc1ncc(C#N)s1.F.O.O=C([O-])[O-].[K+].[K+].c1ccncc1>>N#Cc1cnc(Nc2nccc3c2OCC3CO)s1",
        "output": "708"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cc1cccc(COCCCNc2ccc3ccccc3n2)c1OCC#N.Cl.O.[Na+].[OH-]>>Cc1cccc(COCCCNc2ccc3ccccc3n2)c1OCC(=O)O",
        "output": "259"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.CCc1ccc(N)cc1.c1ccncc1>>CCc1ccc(NC(C)=O)cc1",
        "output": "6"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)CO.CCOCC.CCc1cc2c(O)c(C(=O)O)cnc2s1.FB(F)F>>CCc1cc2c(O)c(C(=O)OCC(C)C)cnc2s1",
        "output": "521"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)O.CCO.ClCCl.Cl[Pd]Cl.O=[N+]([O-])c1cc(Cl)ccc1-c1ccccc1.O=[N+]([O-])c1cc(Cl)ccc1Br.OB(O)c1ccccc1.[Fe+2].[Fe].[Na+].[OH-].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Nc1cc(Cl)ccc1-c1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.NCCBr.O=[N+]([O-])c1cc(C(F)(F)F)c(Cl)c([N+](=O)[O-])c1Cl>>O=[N+]([O-])c1cc(C(F)(F)F)c(Cl)c([N+](=O)[O-])c1NCCBr",
        "output": "304"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(Cc1cccc(Br)c1)c1[nH]c2ccc(OC)cc2c1SC(C)(C)C.CI>>CCOC(=O)C(Cc1cccc(Br)c1)c1c(SC(C)(C)C)c2cc(OC)ccc2n1C",
        "output": "191"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Cl.Nc1nc2c(s1)Cc1ccccc1-2.O=C(Cl)c1ccncc1.O=C([O-])[O-].[K+].[K+]>>O=C(Nc1nc2c(s1)Cc1ccccc1-2)c1ccncc1",
        "output": "673"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc(C=O)cc(Br)c1O.Cl.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-].c1ccncc1>>O=Cc1cc(O)c(O)c(Br)c1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cc(Cl)ccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(C(=O)NCCO)cc1.Cl.NO.O=C([O-])O.[Na+]>>Cc1cc(Cl)ccc1C(C/C(=N\\O)c1ccc(=O)n(C)c1)c1ccc(C(=O)NCCO)cc1",
        "output": "966"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNCCOC.ClCCl.OCCCC#Cc1ccc2c(-c3ccc(F)cc3)csc2c1>>COCCN(C)CCCC#Cc1ccc2c(-c3ccc(F)cc3)csc2c1",
        "output": "371"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCNCC1CCNC1.O=C(O)c1cn(-c2nccs2)c2c(F)c(F)c(F)cc2c1=O>>CCNCC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(-c4nccs4)c3c2F)C1",
        "output": "676"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1cc2ncn(Cc3ccccc3)c(=O)c2cc1O.Cc1ccc(S(=O)(=O)OCCCl)cc1.O.O=C([O-])[O-].[K+].[K+]>>COc1cc2ncn(Cc3ccccc3)c(=O)c2cc1OCCCl",
        "output": "438"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COc1cccc(CC2CNCCN2)c1OC.ClCCl.O.O=C(Cl)OCc1ccccc1.O=C([O-])O.[Na+]>>COc1cccc(CC2CN(C(=O)OCc3ccccc3)CCN2)c1OC",
        "output": "427"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#Cc1ccc(OCc2ccccc2)nn1.O=C(N1CCc2ccc(I)cc2CC1)C(F)(F)F>>O=C(N1CCc2ccc(C#Cc3ccc(OCc4ccccc4)nn3)cc2CC1)C(F)(F)F",
        "output": "664"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)c1ccncc1.Nc1cnc2[nH]cc(-c3ccoc3)c2c1.O=C(Cl)c1ccc(F)cc1>>O=C(Nc1cnc2[nH]cc(-c3ccoc3)c2c1)c1ccc(F)cc1",
        "output": "501"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCC.COc1ccccc1.ClCCl.Nc1nc(C(=NOCC(=O)O)C(=O)NC2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(S/C=C\\c4cccnc4)CS[C@H]23)ns1.O=C(O)C(F)(F)F>>Nc1nc(C(=NOCC(=O)O)C(=O)NC2C(=O)N3C(C(=O)O)=C(S/C=C\\c4cccnc4)CS[C@H]23)ns1",
        "output": "228"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.C1CN[C@H](CN2CCCC2)C1.CCN(CC)CC.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(-c2ccc([N+](=O)[O-])cc2)cc1>>O=C(c1ccc(-c2ccc([N+](=O)[O-])cc2)cc1)N1CCC[C@H]1CN1CCCC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)Nc1nc2cc(OC)ccc2nc1OC.COc1cccc(N2CCNCC2)c1>>COc1cccc(N2CCN(C(=O)Nc3nc4cc(OC)ccc4nc3OC)CC2)c1",
        "output": "613"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCO.CN(C)C=O.O=[N+]([O-])c1ccc(Cl)nc1.[H-].[Na+]>>CCCCOc1ccc([N+](=O)[O-])cn1",
        "output": "433"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NCCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.O=S(=O)(Cl)c1cccc2ccccc12>>O=C(N[C@@H](CCCCNS(=O)(=O)c1cccc2ccccc12)C(=O)O)OCC1c2ccccc2-c2ccccc21",
        "output": "43"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.N#Cc1cccc(CBr)c1.O=C([O-])[O-].O=[N+]([O-])c1cn[nH]c1.[K+].[K+]>>N#Cc1cccc(Cn2cc([N+](=O)[O-])cn2)c1",
        "output": "635"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)O.CCOC(=O)C(C#N)=NOC(N(C)C)=[N+](C)C.CCOC(=O)N1CCNCC1.CN(C)C=O.F[B-](F)(F)F.O=C([O-])O.[Na+]>>CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCc2ccccc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2N)C(C)C)ccc1OC.ClCCl.O=C([O-])O.O=S(=O)(Cl)Cc1ccccc1.[Na+]>>COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2NS(=O)(=O)Cc2ccccc2)C(C)C)ccc1OC",
        "output": "493"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[Si](C)(C)[N-][Si](C)(C)C.Cc1cc(N)nc(N)c1.[Li+]>>Cc1cc(N)nc(NC(=O)OC(C)(C)C)c1",
        "output": "849"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NCCC[C@H](N)CO[Si](C)(C)C(C)(C)C.CCN(CC)CC.ClCCl.O=[N+]([O-])c1cnc2ccccc2c1Cl>>CC(C)(C)OC(=O)NCCC[C@@H](CO[Si](C)(C)C(C)(C)C)Nc1c([N+](=O)[O-])cnc2ccccc12",
        "output": "78"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1ccc(C(=O)Nc2ccc(Cl)cn2)c(NC(C)C2CCN(C(=O)OC(C)(C)C)CC2)c1.[B-][N+](C)(C)C>>COC(=O)c1ccc(C(=O)Nc2ccc(Cl)cn2)c(NC(C)C2CCNCC2)c1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(CC)CC.CCOC(=O)N1CCN(C(=O)[C@@H](N)CCC(=O)OC(C)(C)C)CC1.O.O=C(Cl)C(=O)Cl.O=C(O)c1cc(Cl)nc(-c2ccccc2)n1>>CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(Cl)nc(-c3ccccc3)n2)CC1",
        "output": "738"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(CCO)CC1.CCN(CC)CC.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CCC(CCOS(C)(=O)=O)CC1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Nc1cc(Nc2ccc(Br)cc2[N+](=O)[O-])cc(-n2cncn2)c1.CCO.[Ca+2].[Cl-].[Cl-].[Fe]>>CC(=O)Nc1cc(Nc2ccc(Br)cc2N)cc(-n2cncn2)c1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1cc(COC2CCNCC2)c2ccccc2n1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(COC2CCN(S(C)(=O)=O)CC2)c2ccccc2n1",
        "output": "584"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(C)=O.Cc1ccccc1[C@H](CC(=O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1.Cl.NO.O.O=C([O-])O.[Na+]>>Cc1ccccc1[C@@H](C/C(=N\\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1",
        "output": "966"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.Nc1ccc(Cl)c(C(=O)O)c1.O=C(Cl)c1cccc(C(F)(F)F)c1>>O=C(Nc1ccc(Cl)c(C(=O)O)c1)c1cccc(C(F)(F)F)c1",
        "output": "11"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#C[C@@H](CO)NC(=O)OC(C)(C)C.CC(C)(C)[Si](C)(C)Cl.ClCCl.c1c[nH]cn1>>C#C[C@@H](CO[Si](C)(C)C(C)(C)C)NC(=O)OC(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Brc1ccc2scnc2c1.Nc1ncnc2ccccc12.O=C(O)C1CCN(c2ccc3scnc3c2)CC1>>O=C(Nc1ncnc2ccccc12)C1CCN(c2ccc3scnc3c2)CC1",
        "output": "368"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CN(C)C=O.CO.COCOCc1cc2cc(-c3nc4cc(F)cc(F)c4c(=O)[nH]3)ccc2o1.C[O-].O.[Na+]>>COCOCc1cc2cc(-c3nc4cc(F)cc(OC)c4c(=O)[nH]3)ccc2o1",
        "output": "958"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)c1ccncc1.COc1cc2nccc(Cl)c2cc1OC.Clc1ccccc1Cl.Oc1ccc2ncsc2c1I>>COc1cc2nccc(Oc3ccc4ncsc4c3I)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.CCCCCC.OCCC(O)c1ccccc1.OCC[C@H](O)c1ccccc1>>O=C(CCO)c1ccccc1",
        "output": "32"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=Cc1ccc(F)cc1.Oc1ccc(Cl)c(C(F)(F)F)c1>>O=Cc1ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)cc1",
        "output": "564"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C#N)c1cccs1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(CN)c1cccs1",
        "output": "246"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1CCNCC1.O=C1Nc2cccnc2N(C(=O)CCCCCCl)c2ccccc21>>CN1CCN(CCCCCC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1",
        "output": "138"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCNC(=O)[C@@H]1CCCN1.CCOC(=O)N1CCN(C(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)O)c3ccc(C)cc3n2)CC1.CN(C)C=O.ClCCCl.O.O=C(O)C(F)(F)F.Oc1c(F)c(F)c(F)c(F)c1F>>CCNC(=O)[C@@H]1CCCN1C(=O)COc1cc(C(=O)N[C@@H](CC(=O)OC(C)(C)C)C(=O)N2CCN(C(=O)OCC)CC2)nc2cc(C)ccc12",
        "output": "297"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(N)n(C)n1.F[P-](F)(F)(F)(F)F.N#Cc1ccc(-c2cc(N3CCC[C@H](C(=O)O)C3)nc(N)n2)cc1F>>Cc1cc(NC(=O)[C@H]2CCCN(c3cc(-c4ccc(C#N)c(F)c4)nc(N)n3)C2)n(C)n1",
        "output": "795"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cn1c(CO)nc2cc(N)cnc21.O=C(O)c1cc2cc(F)ccc2n1Cc1cccc(F)c1>>Cn1c(CO)nc2cc(NC(=O)c3cc4cc(F)ccc4n3Cc3cccc(F)c3)cnc21",
        "output": "776"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1cccc2cnccc12.C1COCCN1.CC(=O)[O-].CC(=O)[O-].Cc1ccccc1.ClCCl.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>c1cc(N2CCOCC2)c2ccncc2c1",
        "output": "294"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN(C)CCCN.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(-n2[nH]c3c(nnc4ccccc43)c2=O)cc1>>CN(C)CCCNC(=O)c1ccc(-n2[nH]c3c(nnc4ccccc43)c2=O)cc1",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCCC1CN(C2CCOCC2)C(=O)N1C1CCNCC1.COC(=O)c1ccc(Sc2ccc(C=O)c(C)n2)cc1.ClCCl.[Na+]>>CCCCC1CN(C2CCOCC2)C(=O)N1C1CCN(Cc2ccc(Sc3ccc(C(=O)OC)cc3)nc2C)CC1",
        "output": "757"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCO.CCOC(=O)C(CN1CCC(c2ccc(OC)cc2)CC1)C1CCNCC1>>CCOC(=O)C(CN1CCC(c2ccc(OC)cc2)CC1)C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "694"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(CO)CC1.CCOC(=O)/N=N/C(=O)OCC.O=[N+]([O-])c1ccc(O)cc1F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCC(COc2ccc([N+](=O)[O-])c(F)c2)CC1",
        "output": "478"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)c2nc3ccccc3s2)CC1.CCOCC.O=C(O)C(F)(F)F>>O=C(c1nc2ccccc2s1)C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.Nc1ccc2cnccc2c1.O.c1ccncc1>>Cc1ccc(S(=O)(=O)Nc2ccc3cnccc3c2)cc1",
        "output": "68"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(C(C)(O)Cn2c3c(c4cc(C)ccc42)CN(C)CC3)cn1.Cl>>Cc1ccc2c(c1)c1c(n2CC(C)(O)c2ccc(O)nc2)CCN(C)C1",
        "output": "408"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.C[Si](C)(C)C#Cc1ccc(N)nc1.O=C([O-])[O-].[K+].[K+]>>C#Cc1ccc(N)nc1",
        "output": "337"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.O=C1CCN(c2ccc(Br)cc2)CC1.[Cl-].[K+].[Na+]>>CC1(C)OB(c2ccc(N3CCC(=O)CC3)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(COCc1cccc(Oc2ccccc2)c1)c1ccc(O)c(Cl)c1.CO.[Na+].[OH-].[Pd]>>CC(C)(COCc1cccc(Oc2ccccc2)c1)c1ccc(O)cc1",
        "output": "253"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)N.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCOC(=O)c1cc(C)nc(Cl)c1.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)c1cc(C)nc(NC(C)C)c1",
        "output": "70"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(NC(=O)c2cccc(-c3nc(Nc4ccc(OC)c(OC)c4)c4ncsc4n3)c2)cc1OC.[Na+].[OH-]>>COc1ccc(Nc2nc(-c3cccc(C(=O)Nc4ccc(C(=O)O)c(OC)c4)c3)nc3scnc23)cc1OC",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCBr.CN(C)C=O.O=C([O-])[O-].Sc1cccc(Br)c1.[K+].[K+]>>CCCSc1cccc(Br)c1",
        "output": "124"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=[N+]([O-])c1cnc(N[C@@H]2CC[C@@H](O)CC2)nc1NC1CCCC1.[Pd]>>Nc1cnc(N[C@@H]2CC[C@@H](O)CC2)nc1NC1CCCC1",
        "output": "660"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.COCOc1cccc2c1C(CO)CN2C(=O)OC(C)(C)C.CS(=O)(=O)Cl.ClCCl>>COCOc1cccc2c1C(COS(C)(=O)=O)CN2C(=O)OC(C)(C)C",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN.CN(C)C=O.Cl.O=C(O)c1cccc([N+](=O)[O-])c1OCCOCCOCCO.Oc1cccc2[nH]nnc12>>CNC(=O)c1cccc([N+](=O)[O-])c1OCCOCCOCCO",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccccn1.C#CCCO.[Cu]I>>OCCC#Cc1ccccn1",
        "output": "777"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.Cc1ccc(-n2nc(C3(C)CC3)cc2NC(=O)Nc2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)nc2C)cc1.Cl.ClCCl>>Cc1ccc(-n2nc(C3(C)CC3)cc2NC(=O)Nc2ccc(N3CCNCC3)nc2C)cc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COC(=O)c1ccc2cc(C(=O)NOC(c3ccccc3)(c3ccccc3)c3ccccc3)sc2c1.O.[Na+].[OH-]>>O=C(O)c1ccc2cc(C(=O)NOC(c3ccccc3)(c3ccccc3)c3ccccc3)sc2c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(F)Cn1ncc2cc(Oc3ccc(F)cc3F)c(C(=O)O)cc21.CN(C)C=O.ClCCCl.ClCCl.N[C@H]1CCNC1=O.O.On1nnc2ccccc21.On1nnc2ccccc21>>CC(C)(F)Cn1ncc2cc(Oc3ccc(F)cc3F)c(C(=O)N[C@H]3CCNC3=O)cc21",
        "output": "718"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cl.Cl.ClCCl.NC1CCN(CCCOc2ccc3c4c(c(=O)oc3c2)CCC4)CC1.O=C(Cl)c1ccc([N+](=O)[O-])cc1.O=C([O-])O.[Na+]>>O=C(NC1CCN(CCCOc2ccc3c4c(c(=O)oc3c2)CCC4)CC1)c1ccc([N+](=O)[O-])cc1",
        "output": "271"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2c(c1)Cc1c(I)n[nH]c1-2.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>O=C(c1ccc2c(c1)Cc1c(I)n[nH]c1-2)N1CCOCC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CC1=CS(=O)(=O)c2ccccc2N1.CO.O.[Li+].[OH-]>>O=C(O)CC1=CS(=O)(=O)c2ccccc2N1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN.COC(=O)c1ccsc1S(=O)(=O)Cl.Cl.ClC(Cl)Cl>>CNS(=O)(=O)c1sccc1C(=O)OC",
        "output": "600"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=S(=O)(Nc1ncc(Cl)nc1Cl)c1cccc(Cl)c1Cl.OCc1ccncc1>>O=S(=O)(Nc1ncc(Cl)nc1OCc1ccncc1)c1cccc(Cl)c1Cl",
        "output": "209"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCc1cnc(CC)c(N[C@@H]2c3ccccc3C[C@@H]2O)n1.ClCCl.O=C1CCC(=O)N1Br>>CCc1nc(N[C@@H]2c3ccccc3C[C@@H]2O)c(CC)nc1Br",
        "output": "665"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(O)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(OC)nc1C.CCI.CN(C)C=O.[H-].[Na+]>>CCOC(CC)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(OC)nc1C",
        "output": "307"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)Nc1nc(NCCCOc2cccc(CN(C)C)c2)n(C)n1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCNc1nc(NCCCOc2cccc(CN(C)C)c2)n(C)n1",
        "output": "112"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cnc(Cl)c(C(N)=O)c1.ClCCl.O=C([O-])[O-].O=P(c1ccccc1)(c1ccccc1)c1ccccc1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.[Na+].[Na+]>>COc1cnc(Cl)c(C#N)c1",
        "output": "624"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(C(NC(=O)Cc2ccc3oc(C(C)(O)c4ccncc4)cc3c2)c2ccccc2)c(C)c1.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cc1ccc(C(NC(=O)Cc2ccc3oc(C(C)(O)c4cc[n+]([O-])cc4)cc3c2)c2ccccc2)c(C)c1",
        "output": "262"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)CC1.CC(C)(C)[O-].CCCCc1cc(F)c2ncccc2c1.CN1CCCC1=O.[Cl-].[NH4+].[Na+]>>CCCCc1cc(OC2CCN(C(=O)OC(C)(C)C)CC2)c2ncccc2c1",
        "output": "823"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCN(CC1CC1)c1nc2ccc(OC)cc2cc1C=O.CCO.CCOCC.[BH4-].[Cl-].[NH4+].[Na+]>>CCCN(CC1CC1)c1nc2ccc(OC)cc2cc1CO",
        "output": "476"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CC(N2CCc3nc(C4CCNCC4)sc3CC2)C1.Cc1cnc(C(=O)O)cn1>>Cc1cnc(C(=O)N2CCC(c3nc4c(s3)CCN(C3CCC3)CC4)CC2)cn1",
        "output": "729"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3Cc2cnn(C)c2)cc1.CO.Cl.O.[Na+].[OH-]>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCN3Cc2cnn(C)c2)cc1",
        "output": "58"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)CC(C)(C)C(c1ccccc1NS(C)(=O)=O)N2.[Na+].[OH-]>>CC1(C)Cc2cc(C(=O)O)ccc2NC1c1ccccc1NS(C)(=O)=O",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "B.C1CCOC1.CCCCCCCCCCCCCOc1ccc(C(=O)O)cc1>>CCCCCCCCCCCCCOc1ccc(CO)cc1",
        "output": "72"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCc1nc2cnc3cc(OCc4ccccc4)ccc3c2n1NC(C)C.Cc1ccc(S(=O)(=O)Cl)cc1.ClC(Cl)Cl.O.[NH4+].[OH-]>>CCOCc1nc2c(N)nc3cc(OCc4ccccc4)ccc3c2n1NC(C)C",
        "output": "959"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1ccc(-c2ccc(OCC3CCN(CC(F)(CC)CC)CC3)cc2)cc1F.O.[Li]O>>CCC(F)(CC)CN1CCC(COc2ccc(-c3ccc(C(=O)O)c(F)c3)cc2)CC1",
        "output": "5"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)C[C@@H](Nc1ncc(C#N)cc1C(=O)N[C@@H](C)c1ccc(F)cc1)c1ccc(-c2cn(S(=O)(=O)c3ccccc3)c3ncnc(N)c23)cc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)C[C@@H](Nc1ncc(C#N)cc1C(=O)N[C@@H](C)c1ccc(F)cc1)c1ccc(-c2c[nH]c3ncnc(N)c23)cc1",
        "output": "831"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CO[C@@H](CO)c1cnc(-n2cnnn2)cn1.ClCCl>>CO[C@@H](C=O)c1cnc(-n2cnnn2)cn1",
        "output": "142"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCCCCCN(CCc1ccc(CC(OCC)C(=O)OC)cc1)C(=O)Cc1ccc(C)cc1.[Li+].[OH-]>>CCCCCCCN(CCc1ccc(CC(OCC)C(=O)O)cc1)C(=O)Cc1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.CCc1c(OC)cccc1-c1nc2c(C#N)cc(OC)cc2s1>>CCc1c(O)cccc1-c1nc2c(C#N)cc(O)cc2s1",
        "output": "20"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCN(CC1CCNCC1)C1CCc2ccc([N+](=O)[O-])cc2C1.CCN(CC)CC.ClCCl.O=C(Cl)N1CCOCC1>>CCCN(CC1CCN(C(=O)N2CCOCC2)CC1)C1CCc2ccc([N+](=O)[O-])cc2C1",
        "output": "258"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(OC)cc(N2CCN(C(=O)c3nc(SC)[nH]c3-c3ccccc3)CC2)c1.ClCCl.O=C(OO)c1cccc(Cl)c1>>COc1cc(OC)cc(N2CCN(C(=O)c3nc(S(C)=O)[nH]c3-c3ccccc3)CC2)c1",
        "output": "595"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccccc1CCNS(=O)(=O)c1ccc(C)cc1.O=S(=O)(NCCc1ccccc1O)c1ccc(Oc2ccc(F)cc2)cc1>>Cc1ccc(S(=O)(=O)NCCc2ccccc2O)cc1",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)CSCC1(c2ccccc2)OCC(C)(C)CO1.O.[Li+].[OH-]>>CC1(C)COC(CSCC(=O)O)(c2ccccc2)OC1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(C)c(C(=O)Cl)c1.Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1.O=C1CC(=O)N(c2ccc(NC(=O)c3ccccc3)cc2)c2ccc3ccccc3c2N1>>Cc1ccc(C)c(C(=O)Nc2ccc(N3C(=O)CC(=O)Nc4c3ccc3ccccc43)cc2)c1",
        "output": "11"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1c(F)ccc(C=O)c1OC.ClCCl>>O=Cc1ccc(F)c(O)c1O",
        "output": "19"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.C[C@H](O)CO.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OC[C@H](C)O)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(O)C(C)(C)N.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.Cn1nc(-c2cnc3[nH]cc(C(=O)O)c3n2)c2ccc(Cl)cc21.On1nnc2ccccc21>>CC(O)C(C)(C)NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12",
        "output": "737"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)C.CCN(CC)CC.COc1c(NC(=O)Oc2ccccc2)cc(C(C)(C)C)cc1NS(C)(=O)=O.ClCCl.N#Cc1cc(Nc2cc(Oc3ccc(N)c4ccccc34)ccn2)ccc1OCCN1CCOCC1>>COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(OCCN5CCOCC5)c(C#N)c4)c3)c3ccccc23)cc(C(C)(C)C)cc1NS(C)(=O)=O",
        "output": "965"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCCC1=O.Clc1nc(C2CCCC2)nc2c1CCC2.Nc1ccc(CCO)cc1.O>>OCCc1ccc(Nc2nc(C3CCCC3)nc3c2CCC3)cc1",
        "output": "352"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(CC(=O)Nc1ccccc1N[C@H]1CC[C@H](NC(=O)OC(C)(C)C)CC1)C1CCCc2cccnc21.CN(CC(=O)O)C1CCCc2cccnc21.Nc1ccccc1NCCc1ccccn1>>CN(CC(=O)Nc1ccccc1NCCc1ccccn1)C1CCCc2cccnc21",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCP(=CC#N)(CCCC)CCCC.Cc1ccc(S(=O)(=O)n2c(C3=CCN(C(=O)OC(C)(C)C)CC3)cc3c(-c4cc(O)ccc4F)ccnc32)cc1.Cc1ccccc1.OCc1cccc(F)c1>>Cc1ccc(S(=O)(=O)n2c(C3=CCN(C(=O)OC(C)(C)C)CC3)cc3c(-c4cc(OCc5cccc(F)c5)ccc4F)ccnc32)cc1",
        "output": "347"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CNCCC12CCCN1CCC2.O=[N+]([O-])c1ccccc1Cl>>CN(CCC12CCCN1CCC2)c1ccccc1[N+](=O)[O-]",
        "output": "105"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CCOC(C)=O.O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(OCc3ccccc3)c(F)c2)c1)C1CCCC1.[Pd]>>O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(F)c2)c1)C1CCCC1",
        "output": "23"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCSCCn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN3CCOCC3)ccc21.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O.O=C(OO)c1cccc(Cl)c1>>CCS(=O)CCn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN3CCOCC3)ccc21",
        "output": "13"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.COc1ccc(CSC(CO)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)cc1.CS(C)=O.ClCCl>>COc1ccc(CSC(C=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)cc1",
        "output": "142"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1.Cc1nnc(CC2CCC(c3ncc(-c4ccc(N)cc4)s3)CC2)o1.O=C=Nc1ccccc1Cl>>Cc1nnc(CC2CCC(c3ncc(-c4ccc(NC(=O)Nc5ccccc5Cl)cc4)s3)CC2)o1",
        "output": "473"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrB(Br)Br.COc1ccc2sc3cc(-c4ccccc4Cl)c4c(c3c2c1)C(=O)NC4=O>>O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1sc3ccc(O)cc3c21",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCc1ccc(-c2cc(F)c(B(O)O)c(F)c2)cc1.CCc1ccc(Br)s1>>CCc1ccc(-c2cc(F)c(-c3ccc(CC)s3)c(F)c2)cc1",
        "output": "864"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)Cn1c(C)c(Sc2ccc(S(=O)(=O)N3CCCC3)cc2)c2c1CC(C)(C)CC2=O.O.[Na+].[OH-]>>Cc1c(Sc2ccc(S(=O)(=O)N3CCCC3)cc2)c2c(n1CC(=O)O)CC(C)(C)CC2=O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.O=Cc1ccc(OCCCCl)cc1.[BH4-].[Cl-].[NH4+].[Na+]>>OCc1ccc(OCCCCl)cc1",
        "output": "356"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOCC.Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)NC3CN(C(=O)OC(C)(C)C)CC(F)(F)C3)n2c1.Cl>>Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)NC3CNCC(F)(F)C3)n2c1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.Cc1c(Br)ccc(C#CCN2CCN(C)CC2)c1Cl.I.[Na+].[OH-]>>Cc1c(Br)ccc(CCCN2CCN(C)CC2)c1Cl",
        "output": "717"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cn2c(=O)c(OCc3ccccc3)c(-c3ncc(Cc4ccc(F)cc4)s3)nc2s1.ClCCl>>Cc1cn2c(=O)c(O)c(-c3ncc(Cc4ccc(F)cc4)s3)nc2s1",
        "output": "492"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc2ccc(S(=O)(=O)Cl)cc2c1.ClCCl.Nc1ccc(CCN2CC[C@H](N)C2=O)cc1[N+](=O)[O-]>>COc1ccc2ccc(S(=O)(=O)N[C@H]3CCN(CCc4ccc(N)c([N+](=O)[O-])c4)C3=O)cc2c1",
        "output": "596"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.O=C(Nc1cc(-c2cccs2)ccc1[N+](=O)[O-])OCC1CCCCC1.O=C[O-].[NH4+].[Zn]>>Nc1ccc(-c2cccs2)cc1NC(=O)OCC1CCCCC1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)C(Cl)CSCC(N)=O.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.c1ccncc1>>COC(=O)C(Cl)CSCC#N",
        "output": "172"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.O=C(O)c1ccc(C(F)(F)F)nc1>>OCc1ccc(C(F)(F)F)nc1",
        "output": "293"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1ccc(CNC23CC4CC(CC(C4)C2)C3)cc1.CC#N.NC12CC3CC(CC(C3)C1)C2.O=Cc1ccc2cn[nH]c2c1>>c1cc2cn[nH]c2cc1CNC12CC3CC(CC(C3)C1)C2",
        "output": "468"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCCc1nc2c(N)nc3ccccc3c2n1CCCN.O=C=NC1CCCCC1>>COCCc1nc2c(N)nc3ccccc3c2n1CCCNC(=O)NC1CCCCC1",
        "output": "244"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc(-c2c(=O)[nH]c3cc(Cl)c(Cl)cc3[n+]2[O-])cc1.ClCCl>>O=c1[nH]c2cc(Cl)c(Cl)cc2[n+]([O-])c1-c1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)[C@H](C=C(Cl)C(F)(F)F)[C@@H]1C(=O)Cl.Cc1ccccc1.O[C@@H]1C[C@@H](Cc2cccc(F)c2)c2ccccc21.c1ccncc1>>CC1(C)[C@H](C=C(Cl)C(F)(F)F)[C@@H]1C(=O)O[C@@H]1C[C@@H](Cc2cccc(F)c2)c2ccccc21",
        "output": "126"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NC12CC3CC(CC(C3)C1)C2.O=Cc1c(O)cc(O)cc1O>>Oc1cc(O)c(CNC23CC4CC(CC(C4)C2)C3)c(O)c1",
        "output": "468"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)C1Cc2cc(N)ccc2O1.COc1ccc(Nc2nc(Cl)ncc2F)c(OC)n1>>COC(=O)C1Cc2cc(Nc3ncc(F)c(Nc4ccc(OC)nc4OC)n3)ccc2O1",
        "output": "907"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.CCOCC.ClCCl.Nc1nc2c(s1)CCN(CC=Cc1cccc(OCc3ccccc3)c1)CC2>>Nc1nc2c(s1)CCN(CC=Cc1cccc(O)c1)CC2",
        "output": "23"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C(O)C1CCNCC1.O=Cc1ccc(-c2noc(-c3nnn(-c4ccccc4F)c3-c3ccncc3)n2)cc1>>O=C(O)C1CCN(Cc2ccc(-c3noc(-c4nnn(-c5ccccc5F)c4-c4ccncc4)n3)cc2)CC1",
        "output": "567"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCS(=O)(=O)Cl.CCN(CC)CC.Cc1nc2cccc3n(CCCCN)c(=O)c1n23.ClCCl>>CCCS(=O)(=O)NCCCCn1c(=O)c2c(C)nc3cccc1n32",
        "output": "493"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)NS(=O)(=O)c1ccc(C#N)o1.O=C(O)C(F)(F)F>>N#Cc1ccc(S(N)(=O)=O)o1",
        "output": "680"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2=CC(=O)CCC2)n1.CCO.[BH4-].[Na+]>>CC(C)Nc1nc(Nc2ccnc(C(F)(F)F)c2)nc(C2=CC(O)CCC2)n1",
        "output": "288"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.Cc1cc(C)nc(N2CCNCC2)n1.Cc1ccc(S(=O)(=O)OCCCc2c[nH]c3ccc(F)cc23)cc1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>Cc1cc(C)nc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)n1",
        "output": "429"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.C[C@@H](N)c1ccccc1.C[C@H](O)[C@@H]1CC(=O)N([C@H](C)c2ccccc2)C1.ClCCl>>C[C@H](OS(C)(=O)=O)[C@@H]1CC(=O)N([C@H](C)c2ccccc2)C1",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.C[Si](C)(C)C#Cc1c(Cl)cccc1Cl.O=C([O-])[O-].[K+].[K+]>>C#Cc1c(Cl)cccc1Cl",
        "output": "337"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.Cc1ccccc1.O=S1(=O)c2cccc3cccc(c23)N1CCCCl.c1ccc(N2CCNCC2)cc1>>O=S1(=O)c2cccc3cccc(c23)N1CCCN1CCN(c2ccccc2)CC1",
        "output": "138"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOCC.COC(=O)c1cnc2cc(CN(C)c3ccccc3)ccc2c1.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>CN(Cc1ccc2cc(CO)cnc2c1)c1ccccc1",
        "output": "522"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1cc(NS(=O)(=O)c2ccccc2)ccc1NCC1CCCO1.[Pd]>>Nc1cc(NS(=O)(=O)c2ccccc2)ccc1NCC1CCCO1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)n1cc(CNC(=O)c2ncc3cccnc3c2O)c2ccccc21.ClCCl.O=C(O)C(F)(F)F>>O=C(NCc1c[nH]c2ccccc12)c1ncc2cccnc2c1O",
        "output": "848"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(CO)ccc1NC(=O)c1cc(C)n(Cc2cc(Cl)ccc2OCC(C)C)n1.ClCCl>>COc1cc(C=O)ccc1NC(=O)c1cc(C)n(Cc2cc(Cl)ccc2OCC(C)C)n1",
        "output": "179"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrBr.CCCCCCc1ccc2c(c1)C(C)(C)CCC2(C)C.ClC(Cl)(Cl)Cl.[Fe]>>CCCCCCc1cc2c(cc1Br)C(C)(C)CCC2(C)C",
        "output": "98"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COCc1nc2cc([N+](=O)[O-])ccc2n1S(=O)(=O)c1ccc(C)cc1>>COCc1nc2cc(N)ccc2n1S(=O)(=O)c1ccc(C)cc1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(=O)(=O)CC(N)=NO.O=C(O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)N2CCOCC2)C1>>CS(=O)(=O)Cc1noc(C2CC(c3ccc(OC(F)(F)F)cc3)CN(C(=O)N3CCOCC3)C2)n1",
        "output": "728"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.CC(=O)O.O=C1CCc2cc(F)ccc21>>O=C1c2ccc(F)cc2CC1Br",
        "output": "82"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCc1c(C(C)C)nc(C(C)C)c(C=O)c1-c1ccc(F)cc1.CCN.CCOCC.ClCCl>>CCCCCc1c(C(C)C)nc(C(C)C)c(CNCC)c1-c1ccc(F)cc1",
        "output": "441"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCO.CCN(C(C)C)C(C)C.Cc1cc(Nc2cc(C)[nH]n2)nc(Cl)n1.c1ccc(-c2cc(C3CCN3)on2)nc1>>Cc1cc(Nc2cc(C)[nH]n2)nc(N2CCC2c2cc(-c3ccccn3)no2)n1",
        "output": "36"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)c1cc(N)ccc1Cl.CCCCCC.CCOC(C)=O.CO.O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C([O-])[O-].O=[N+]([O-])[O-].[K+].[K+].[K+]>>CC(C)c1cc(N)c([N+](=O)[O-])cc1Cl",
        "output": "103"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(OC)c(CO)c1.ClCCl.O=S(Cl)Cl>>COc1ccc(OC)c(CCl)c1",
        "output": "81"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(O)Br.COC(=O)Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>CC1(C)OB(c2cnn(CCO)c2)OC1(C)C",
        "output": "343"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCC1CCCC1.N#Cc1ccc(Cn2c(-c3ccc(Cl)cc3O)nc3cc(F)c(F)cc32)cc1F>>N#Cc1ccc(Cn2c(-c3ccc(Cl)cc3OCC3CCCC3)nc3cc(F)c(F)cc32)cc1F",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=C(C)C(=O)O.CC(=O)N(C)C.N#Cc1ccc(N)cc1C(F)(F)F.O=S(Cl)Cl>>C=C(C)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1",
        "output": "170"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(Cl)Cl.CCOC(=O)c1ccc[n+]([O-])c1-c1ccc(F)cc1F.O=P(Cl)(Cl)Cl>>CCOC(=O)c1ccc(Cl)nc1-c1ccc(F)cc1F",
        "output": "2"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(C2CCNC2)cc1.O=C(O)C(=O)O.O=C(O)c1cnoc1-c1ccc(C(F)(F)F)cc1>>Cc1ccc(C2CCN(C(=O)c3cnoc3-c3ccc(C(F)(F)F)cc3)C2)cc1",
        "output": "975"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.O=C(O)c1cnc(Cl)c(Cl)c1.O=C1OCc2ccccc2N1C1CCNCC1>>O=C(O)c1cnc(N2CCC(N3C(=O)OCc4ccccc43)CC2)c(Cl)c1",
        "output": "220"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCC(CC)(c1ccc(C#CC2(O)CCSCC2)c(C)c1)c1ccc(-c2cncc(CC(=O)OC)c2)c(C)c1.CO.[Na+].[OH-]>>CCC(CC)(c1ccc(C#CC2(O)CCSCC2)c(C)c1)c1ccc(-c2cncc(CC(=O)O)c2)c(C)c1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=C1CCCN1c1ccc([N+](=O)[O-])cn1.[Pd]>>Nc1ccc(N2CCCC2=O)nc1",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.O=[N+]([O-])c1cc(O)ccc1-c1ccccc1.OCCCCCCCCBr>>O=[N+]([O-])c1cc(OCCCCCCCCO)ccc1-c1ccccc1",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.CN(C)C=O.CS(=O)(=O)O.CS(C)=O.F[P-](F)(F)(F)(F)F.NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O.O=C(O)C(F)(F)c1c(F)cccc1F>>O=C1CCC(N2Cc3cc(CNC(=O)C(F)(F)c4c(F)cccc4F)ccc3C2=O)C(=O)N1",
        "output": "599"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CNCCCS(=O)CCC(F)(F)F.Oc1cccc(C2=C(CCCCCCBr)c3ccc(O)cc3CCC2)c1>>CN(CCCCCCC1=C(c2cccc(O)c2)CCCc2cc(O)ccc21)CCCS(=O)CCC(F)(F)F",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(CC)c1NC(=O)c1ccc(-n2cncn2)c([N+](=O)[O-])c1.[Pd]>>CCc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(CC)c1NC(=O)c1ccc(-n2cncn2)c(N)c1",
        "output": "489"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC#N.CC(C)(C)Cc1cc(C(=O)O)no1.CC(C)(C)N.ClCCCl.On1nnc2ccccc21>>CC(C)(C)Cc1cc(C(=O)NC(C)(C)C)no1",
        "output": "696"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C1C(Br)=C(c2ccccc2)c2ccc(O)cc21.O=C1C(c2cccnc2)=C(c2cc(F)cc(F)c2)c2ccc(O)cc21.OCCc1ccccn1>>O=C1C(c2cccnc2)=C(c2cc(F)cc(F)c2)c2ccc(OCCc3ccccn3)cc21",
        "output": "478"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCO.Cl.Clc1ccncn1.O=C(C1CCNCC1)N1CCN(Cc2ccccc2)CC1>>O=C(C1CCN(c2ccncn2)CC1)N1CCN(Cc2ccccc2)CC1",
        "output": "162"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCC(N)c1nn2cccc2c(=O)n1Cc1ccccc1.ClCCl.O=CCCNC(=O)OCC1c2ccccc2-c2ccccc21.[Na+]>>CCC(NCCCNC(=O)OCC1c2ccccc2-c2ccccc21)c1nn2cccc2c(=O)n1Cc1ccccc1",
        "output": "426"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC1CN(C(=O)C(C)(C)C)c2ccccc2N(CC(=O)C(C)(C)C)C1=O.Cl.ClC(Cl)Cl>>CC(C)(C)C(=O)CN1C(=O)C(N)CN(C(=O)C(C)(C)C)c2ccccc21",
        "output": "431"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.N#CC1CN(c2ncccc2Br)C1.O.[K+].[OH-]>>O=C(O)C1CN(c2ncccc2Br)C1",
        "output": "259"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=C1CC(C(=O)O)C1.CC(=O)O.CO.C[Si](C)(C)C=[N+]=[N-].ClCCl>>C=C1CC(C(=O)OC)C1",
        "output": "195"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCCc1ccc2c(c1)CC(C(NC(C)=O)(C(=O)OCC)C(=O)OCC)C2=O.CC[SiH](CC)CC.ClCCl.Cl[Ti](Cl)(Cl)Cl>>CCCCCCCCc1ccc2c(c1)CC(C(NC(C)=O)(C(=O)OCC)C(=O)OCC)C2",
        "output": "92"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCP(CCCC)CCCC.CCOC(=O)Cn1ccc2ccc(O)cc21.CN(C)C(=O)N=NC(=O)N(C)C.Cn1nc(-c2ccc(C(F)(F)F)cc2)cc1CCCO>>CCOC(=O)Cn1ccc2ccc(OCCCc3cc(-c4ccc(C(F)(F)F)cc4)nn3C)cc21",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COCCO.O=C(CCc1cncs1)N[C@H]1Cc2cccc(C(=O)O)c2OB1O>>COCCOC(=O)c1cccc2c1OB(O)[C@@H](NC(=O)CCc1cncs1)C2",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.CN1CCOCC1.Cc1nc(NN)c(F)c(N(C)CCc2ccncc2)n1.ClCCCl.O=CN(C[C@@H](CC1CCCC1)C(=O)O)OCc1ccccc1.On1nnc2cccnc21>>Cc1nc(NNC(=O)[C@H](CC2CCCC2)CN(C=O)OCc2ccccc2)c(F)c(N(C)CCc2ccncc2)n1",
        "output": "459"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1cccc(-c2ccccc2)c1.C1CCOC1.CN(C)C=O.[Li]C(C)(C)C>>O=Cc1cccc(-c2ccccc2)c1",
        "output": "638"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNCC1.CCO.CN1CCN(Cc2ccc(C(=O)Nc3cccc(Nc4ccc5c(c4)CC(=O)N5)c3)cc2)CC1.O=Cc1ccc[nH]1>>CN1CCN(Cc2ccc(C(=O)Nc3cccc(Nc4ccc5c(c4)C(=Cc4ccc[nH]4)C(=O)N5)c3)cc2)CC1",
        "output": "440"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCOC(=O)c1cc2ccc(OC3CCN(C(=O)OC(C)(C)C)CC3)cc2s1.Cl>>CCOC(=O)c1cc2ccc(OC3CCNCC3)cc2s1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(NCc2ccccc2)c([N+](=O)[O-])c(=O)[nH]1.ClCCl.O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+]>>Cc1cc(NCc2ccccc2)c([N+](=O)[O-])c(Cl)n1",
        "output": "100"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.O.O=Cc1ccc(OCCCCCCCCCCCCO)cc1>>CC(=O)OCCCCCCCCCCCCOc1ccc(C=O)cc1",
        "output": "254"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COCCc1ccc2oc(-c3ccc(OCOC)c(OC)c3)c(SC)c2c1.ClCCl.O.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>COCCc1ccc2oc(-c3ccc(O)c(OC)c3)c(SC)c2c1",
        "output": "755"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)NCC(C)(C)c1ccc(N)cc1Cl.CCN(CC)CC.CN(C)C=O.COc1ccc(C(=O)Cl)cc1OC.ClCCl>>COc1ccc(C(=O)Nc2ccc(C(C)(C)CNC(C)=O)c(Cl)c2)cc1OC",
        "output": "11"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#CC1CN(S(=O)(=O)c2ccc(Cl)nc2)CCN1c1ncc(C(C)(O)C(F)(F)F)cn1.CCO.[NH4+].[OH-]>>CC#CC1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ncc(C(C)(O)C(F)(F)F)cn1",
        "output": "388"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)c1nc(CN)cs1.Cc1nc(N2CCN(CC3CC3(F)F)C2=O)sc1C(=O)O.Cc1nc(N2CCN(Cc3ccc(F)cc3)C2=O)sc1C(=O)O>>Cc1nc(N2CCN(Cc3ccc(F)cc3)C2=O)sc1C(=O)NCc1csc(C(C)C)n1",
        "output": "534"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cccc2c1CCc1ccccc1-2.CCOCC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OCc1cccc2c1CCc1ccccc1-2",
        "output": "311"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC(=O)c1cc(F)cc2c1cnn2C.CCO.Cl.NO.[Na+]>>CC(=NO)c1cc(F)cc2c1cnn2C",
        "output": "212"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[O-].CI.O.O=C1c2cc(Br)ccc2CCC12CCC(O)CC2.[Cl-].[K+].[Na+]>>COC1CCC2(CCc3ccc(Br)cc3C2=O)CC1",
        "output": "140"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.Cc1ccc(O)cn1.O.[H-].[Na+]>>COc1ccc(C)nc1",
        "output": "661"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C#N)c1cccc(C(=O)O)c1.CN(C)C=O.CN1CCCC1=O.Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c(Cl)cc1F.O=C(Cl)C(=O)Cl>>CC(C)(C#N)c1cccc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c(Cl)cc2F)c1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cccc(F)c1-c1ccc(Cl)cc1Cl.Oc1cccc(Cl)c1-c1ccccc1Cl>>Oc1cccc(F)c1-c1ccc(Cl)cc1Cl",
        "output": "48"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CC(N)C1.CCN=C=NCCCN(C)C.O=C(O)CNC(=O)c1ccc(F)c(C(F)(F)F)c1>>CC(C)(C)OC(=O)N1CC(NC(=O)CNC(=O)c2ccc(F)c(C(F)(F)F)c2)C1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.COc1cccc(S(=O)(=O)NCCC(=O)N2CCc3ncn(C)c3C2c2ccc(C#N)c(F)c2)c1.ClCCl.O=C([O-])O.[Na+]>>Cn1cnc2c1C(c1ccc(C#N)c(F)c1)N(C(=O)CCNS(=O)(=O)c1cccc(O)c1)CC2",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)Cc1cccc(CNCCC2CCN(c3nc4ccc(Cl)cc4s3)CC2)c1.Cl.[Na+].[OH-]>>O=C(O)Cc1cccc(CNCCC2CCN(c3nc4ccc(Cl)cc4s3)CC2)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1ccc2[nH]ccc2c1.C1CCOC1.CCCCC.CCOC(C)=O.CN1CCC(=O)CC1.[H-].[K+].[Li]C(C)(C)C>>CN1CCC(O)(c2ccc3[nH]ccc3c2)CC1",
        "output": "321"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(CN)c2ccccc2F)CC1.CCOC(=O)Cl>>CCOC(=O)NCC(c1ccccc1F)N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "94"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.COC1C(OC(=O)NC(=O)CCl)CCC(O)(CSc2ccccc2)C1C1(C)OC1CC=C(C)C.ClCCl.O=C(OO)c1cccc(Cl)c1>>COC1C(OC(=O)NC(=O)CCl)CCC(O)(CS(=O)c2ccccc2)C1C1(C)OC1CC=C(C)C",
        "output": "500"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(Oc2ccc(O)cc2)C1.CCOC(=O)CBr.[H-].[Na+]>>CCOC(=O)COc1ccc(OC2CCN(C(=O)OC(C)(C)C)C2)cc1",
        "output": "123"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COc1cc(C(=O)NC2CN(C)C2)ccc1[N+](=O)[O-].[Pd]>>COc1cc(C(=O)NC2CN(C)C2)ccc1N",
        "output": "28"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(Br)cc23)cc1.Cl.Nc1ccc2[nH]cnc2c1>>Brc1ccc2nc(Nc3ccc4[nH]cnc4c3)c3n[nH]cc3c2c1",
        "output": "998"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.NN.O.O=[N+]([O-])c1ccc(OCc2ccccc2)c(F)c1.[Ni]>>Nc1ccc(OCc2ccccc2)c(F)c1",
        "output": "202"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.Cn1nc(C(=O)O)c2c1-c1ccccc1OC2(C)C.Nc1cccc(Cl)c1.O=C(Cl)C(=O)Cl.c1ccncc1>>Cn1nc(C(=O)Nc2cccc(Cl)c2)c2c1-c1ccccc1OC2(C)C",
        "output": "844"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cn1cnc(-c2nnc3n2CCc2nc(-c4ccc(C5(NC(=O)OC(C)(C)C)CCC5)cc4)c(-c4ccccc4)cc2-3)c1.NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)C(=O)CCC4)cc2)CCC1>>Cn1cnc(-c2nnc3n2CCc2nc(-c4ccc(C5(N)CCC5)cc4)c(-c4ccccc4)cc2-3)c1",
        "output": "793"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(O)c1ccc(C(=O)Nc2cc(N3CCC[C@@H](C(=O)O)C3)n3nccc3n2)cc1.CCN=C=NCCCN(C)C.CN.CN(C)C=O.On1nnc2ccccc21>>CNC(=O)[C@@H]1CCCN(c2cc(NC(=O)c3ccc(C(C)(C)O)cc3)nc3ccnn23)C1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](CN)C1.O=C(O)c1cc(Br)c(Br)[nH]1>>CC(C)(C)OC(=O)N1CC[C@H](CNC(=O)c2cc(Br)c(Br)[nH]2)C1",
        "output": "137"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COC(=O)c1ccc(NC(=O)C2(c3ccc4c(c3)OCO4)CC2)cc1-c1ccc(C(=O)N(C)C)cc1.O=C([O-])[O-].[K+].[K+]>>CN(C)C(=O)c1ccc(-c2cc(NC(=O)C3(c4ccc5c(c4)OCO5)CC3)ccc2C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O=C(O)CO.O=C([O-])O.On1nnc2ccccc21.[Na+].c1cc2[nH]ncc2cc1NC1CC2CCC(C1)N2>>O=C(CO)N1C2CCC1CC(Nc1ccc3[nH]ncc3c1)C2",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCOC(C)=O.ClCCCCCBr.N#Cc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>N#Cc1ccc(OCCCCCCl)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.COc1ccc(C(=O)Nc2ccc(C(C)(C)C#N)cc2)cc1.Cl.N.[H][H].[Ni]>>COc1ccc(C(=O)Nc2ccc(C(C)(C)CN)cc2)cc1",
        "output": "246"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOCC.CI.COCC(C)(N)CO.[H-].[Na+]>>COCC(C)(N)COC",
        "output": "140"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.COC(=O)CC1CCC(c2ccc(-c3ncc([N+](=O)[O-])cc3OC)cc2)CC1.[Pd]>>COC(=O)CC1CCC(c2ccc(-c3ncc(N)cc3OC)cc2)CC1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C(=O)O)c1ccc2c(c1)SCC1CCCCC1C2=O.CCO.Cl>>CCOC(=O)C(C)c1ccc2c(c1)SCC1CCCCC1C2=O",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CS(C)=O.Cc1cc(B(O)O)ccc1Cl.ClCCl.N#CCOc1cc(Br)c(F)cc1-n1c(=O)ccc2cc(S(=O)(=O)Nc3ccon3)ccc21.O.O=C([O-])[O-].[K+].[K+]>>Cc1cc(-c2cc(OCC#N)c(-n3c(=O)ccc4cc(S(=O)(=O)Nc5ccon5)ccc43)cc2F)ccc1Cl",
        "output": "837"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1C[C@H]2C[C@H]2[C@H]1CN.O=C(O)c1cn2ccsc2n1>>CC(C)(C)OC(=O)N1C[C@H]2C[C@H]2[C@H]1CNC(=O)c1cn2ccsc2n1",
        "output": "697"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrC1CCCC1.CN(C)C=O.O=C([O-])[O-].Oc1ccc(Br)c(OCCN2CCCCC2)c1.[K+].[K+]>>Brc1ccc(OC2CCCC2)cc1OCCN1CCCCC1",
        "output": "153"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COc1ccc(C(C)=O)cc1.O=Cc1ccccc1.[Na+].[OH-]>>COc1ccc(C(=O)C=Cc2ccccc2)cc1",
        "output": "295"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCN(CC)CC.Cc1cccnc1Oc1cccc(C=C2CCNCC2)c1.Cl.O=C(Nc1cccnc1)Oc1ccccc1>>Cc1cccnc1Oc1cccc(C=C2CCN(C(=O)Nc3cccnc3)CC2)c1",
        "output": "525"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)O[C@H](c2ccc(-c3ccc(CO)nc3)cc2)[C@@H](CF)N1C(=O)C(F)F.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C([O-])O>>CC1(C)O[C@H](c2ccc(-c3ccc(COS(C)(=O)=O)nc3)cc2)[C@@H](CF)N1C(=O)C(F)F",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1cc(CCC(=O)O)cc(C(C)(C)C)c1O.CCCCCC.CCCCCCCCCCCCCCCCCC(=O)NCCCO.CCCCCCCCCCCCCCCCCC(=O)O.CCCC[O-].CCCC[O-].CCCC[O-].CCCC[O-].C[O-].Cc1ccccc1C.NCCCO.O.[Na+].[Ti+4]>>CCCCCCCCCCCCCCCCCC(=O)NCCCOC(=O)CCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1",
        "output": "47"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(c2ncnc3cc(OC4CNC4)ccc23)CC1.ClCCl>>CC(=O)N1CC(Oc2ccc3c(C4CCN(C(=O)OC(C)(C)C)CC4)ncnc3c2)C1",
        "output": "369"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1[nH]c2ccc(C[C@H]3COC(=O)N3)cc2c1CCN(C)C.[K+].[OH-]>>CN(C)CCc1c(C(=O)O)[nH]c2ccc(C[C@H]3COC(=O)N3)cc12",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(CC)CC.CCc1nc(CC(C)C)c(CNC(=O)OC(C)(C)C)c(-c2ccc(C)cc2)c1CO.CS(=O)(=O)Cl.O>>CCc1nc(CC(C)C)c(CNC(=O)OC(C)(C)C)c(-c2ccc(C)cc2)c1COS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc(Cl)c(C=O)cc1OC.ClCCl.O.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1cc(C=O)c(Cl)cc1O",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCCC1.FC(F)(F)C1CO1.O=C(OCc1ccccc1)N1CCNCC1>>O=C(OCc1ccccc1)N1CCN(CC(O)C(F)(F)F)CC1",
        "output": "76"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CNc1ccn2cc(-c3ccc(Br)cc3)nc2c1.Cl.Cl.FC1CCNCC1>>CNc1ccn2cc(-c3ccc(N4CCC(F)CC4)cc3)nc2c1",
        "output": "294"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1c2c(n(C)c1I)-c1nc(N)ncc1CC2>>Cn1c(I)c(C(=O)O)c2c1-c1nc(N)ncc1CC2",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.NCC1Cc2cccc(-c3ccc(C(F)(F)F)cc3)c2O1.O=C(Cl)OCc1ccccc1>>O=C(NCC1Cc2cccc(-c3ccc(C(F)(F)F)cc3)c2O1)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(=O)COCC(NC(=O)OC(C)(C)C)(c1cccc(Br)c1)C(F)(F)F.Cl.ClCCl>>CCOC(=O)COCC(N)(c1cccc(Br)c1)C(F)(F)F",
        "output": "793"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.O=[N+]([O-])c1c(Br)n[nH]c1Br.OCC(O)CBr.[H-].[Na+]>>O=[N+]([O-])c1c(Br)nn(CC(O)CO)c1Br",
        "output": "577"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(CC1CCCc2ccccc21)c1ccc(O)cc1.Oc1nc(Cl)nc2cnccc12>>CN(CC1CCCc2ccccc21)c1ccc(Oc2nc(O)c3ccncc3n2)cc1",
        "output": "542"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)c1cc([N+](=O)[O-])cn1C1CCCC1.Cl.O.[Na+].[OH-]>>O=C(O)c1cc([N+](=O)[O-])cn1C1CCCC1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)C(=O)Cl.CCN(CC)CC.CN(C)C=O.NCC1CCc2c(sc3ncnc(Nc4ccc5[nH]c(=O)sc5c4)c23)C1.O>>CC(C)C(=O)NCC1CCc2c(sc3ncnc(Nc4ccc5[nH]c(=O)sc5c4)c23)C1",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CS(=O)(=O)c1ccc(CNC(=O)c2ccc3cncc(Br)c3n2)cc1.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccccc1F.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CS(=O)(=O)c1ccc(CNC(=O)c2ccc3cncc(-c4ccccc4F)c3n2)cc1",
        "output": "871"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc(Cl)cnc1NS(=O)(=O)c1cnc(N(C)C)c(Cl)c1.COc1cc(Cl)nnc1NS(=O)(=O)Cc1cc(C#N)ccc1Cl.N#Cc1ccc(Cl)c(CS(=O)(=O)Nc2nnc(Cl)cc2O)c1>>CN(C)c1ncc(S(=O)(=O)Nc2ncc(Cl)cc2O)cc1Cl",
        "output": "424"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)Cc1ccc(OCc2ccc3ccccc3n2)c(Br)c1.[Na+].[OH-]>>O=C(O)Cc1ccc(OCc2ccc3ccccc3n2)c(Br)c1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.CCOC(C)=O.CN(C)c1ccncc1.COc1ccc(-n2c(-c3ccc(C(=O)O)cc3)nc3ccccc32)cc1.ClCCl.NCc1cccs1.O=C([O-])O.[Na+]>>COc1ccc(-n2c(-c3ccc(C(=O)NCc4cccs4)cc3)nc3ccccc32)cc1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Cl.CCN(C(C)C)C(C)C.ClCCl.Nc1ccc([N+](=O)[O-])c(N2CCCCC2)c1>>CC(=O)Nc1ccc([N+](=O)[O-])c(N2CCCCC2)c1",
        "output": "9"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[O-].CN(C)C=O.COC(=O)c1ccc2c(c1)ncn2-c1ccc(O)cc1.FC(F)(F)Oc1ccc(CBr)cc1.[I-].[K+].[Na+]>>COC(=O)c1ccc2c(c1)ncn2-c1ccc(OCc2ccc(OC(F)(F)F)cc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CN1CCC(c2ncc(-c3ccc(N)cc3)s2)CC1.COC(=O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1.O=C=Nc1ccccc1Cl>>CCOC(=O)CN1CCC(c2ncc(-c3ccc(NC(=O)Nc4ccccc4Cl)cc3)s2)CC1",
        "output": "473"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)C1=C(C)NC(C)=C(C(=O)OC)N1c1cccc([N+](=O)[O-])c1.Cl.O.[Fe]>>COC(=O)C1=C(C)NC(C)=C(C(=O)OC)N1c1cccc(N)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.COC(=O)C=Cc1ccc(C)cc1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COC(=O)C=Cc1ccc(CBr)cc1",
        "output": "29"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.Nc1nc(Nc2ccc(Br)c(C(F)(F)F)c2)n[nH]1.O=C([O-])[O-].OB(O)c1ccc(F)c(F)c1.[K+].[K+].[NH4+].[OH-]>>Nc1nc(Nc2ccc(-c3ccc(F)c(F)c3)c(C(F)(F)F)c2)n[nH]1",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.ClCCCl.Nc1cccnc1.O.O=C(O)c1cc(Br)ccc1OCc1ccc(F)cc1.On1nnc2ccccc21>>O=C(Nc1cccnc1)c1cc(Br)ccc1OCc1ccc(F)cc1",
        "output": "759"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1c(C#N)cc2c(c1C(=O)O)CCCC2.ClCCl.O=C(Cl)C(=O)Cl>>COc1c(C#N)cc2c(c1C(=O)Cl)CCCC2",
        "output": "448"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCP(CCCC)CCCC.COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1O.CSCCCO.ClCCl.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCCSC",
        "output": "478"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ncnc(O)c1I.O=P(Cl)(Cl)Cl>>Cc1ncnc(Cl)c1I",
        "output": "168"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)c1ccc(Cl)nc1.OCC(F)F>>CC(=O)c1ccc(OCC(F)F)nc1",
        "output": "433"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCN(CC(=O)O)CC1.NCc1ccco1>>CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCN(CC(=O)NCc2ccco2)CC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CCN(CC)CC.O=C([O-])O.O=C1NC(=O)/C(=C/c2ccccc2N2CCNCC2)S1.[Na+]>>CC(=O)N1CCN(c2ccccc2/C=C2\\SC(=O)NC2=O)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCOc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC)cc1.C1CCOC1.CC(C)(C)O.CCOC(C)=O.C[C@@H](C(=O)N[C@H](C(=O)N1C[C@@H](N=[N+]=[N-])C[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)O)C(C)(C)C)N(C)C(=O)OC(C)(C)C.O.O.O.O.O.O.O=C([O-])/C(O)=C(/O)[C@H](O)[C@@H](O)CO.O=S(=O)([O-])[O-].[Cu+2].[Na+]>>COC(=O)[C@H](Cc1ccc(OCc2cn([C@H]3C[C@@H](C(=O)N[C@@H](Cc4ccc5ccccc5c4)C(=O)O)N(C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(C)(C)C)C3)nn2)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21",
        "output": "963"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.CO.ClC(Cl)Cl.O=C(n1ccnc1)n1ccnc1.c1ccc2c(c1)CCNCC2>>CC(C)(C)c1nc(N2CCN(CCCCNC(=O)N3CCc4ccccc4CC3)CC2)cc(C(F)(F)F)n1",
        "output": "734"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.CCCCC12CCC(=O)C=C1c1ccc(OC)cc1CC2.ClCCl>>CCCCC12CCC(=O)C=C1c1ccc(O)cc1CC2",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)C[C@@H]1COc2cc(NCc3cccc(-n4c([C@H]5CCCO5)nc5cc(C(F)(F)F)ccc54)c3C)ccc21.Cl.O.O.[Li+].[OH-]>>Cc1c(CNc2ccc3c(c2)OC[C@H]3CC(=O)O)cccc1-n1c([C@H]2CCCO2)nc2cc(C(F)(F)F)ccc21",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)C=Cc1ccc(OC(C)C)c(OC)c1.CCOCC.CCOCC.O.O=S(=O)(O)O.[Al+3].[Al+3].[Cl-].[Cl-].[Cl-].[H-].[H-].[H-].[H-].[Li+]>>COc1cc(/C=C/CO)ccc1OC(C)C",
        "output": "150"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(C)c(NC(=O)c2nc(N3CCC(OC)CC3)ccc2C)c(C)c1.O.[Li+].[OH-]>>COC1CCN(c2ccc(C)c(C(=O)Nc3c(C)cc(C(=O)O)cc3C)n2)CC1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1ccc2c(Oc3ccc(/C=C/C(=O)O)cc3)c(-c3ccccc3)c(C)cc2c1.ClCCl.O>>Cc1cc2cc(O)ccc2c(Oc2ccc(/C=C/C(=O)O)cc2)c1-c1ccccc1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)Cc1nc(-c2ccncc2)n[nH]1.O.[Li+].[OH-]>>O=C(O)Cc1nc(-c2ccncc2)n[nH]1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C=C(C)c1ccc(C#Cc2cccc(CN(C)C3CC3)c2)cc1.[K+].[OH-]>>CC(=CC(=O)O)c1ccc(C#Cc2cccc(CN(C)C3CC3)c2)cc1",
        "output": "122"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.Nc1nc(F)nc2nc(Cc3ccc4c(c3)OCO4)[nH]c12.O=C(O)C(F)(F)F.O=C1CCC(=O)N1I>>Nc1nc(F)nc2nc(Cc3cc4c(cc3I)OCO4)[nH]c12",
        "output": "834"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCOCCOCCOCCO1.CN(C)C=O.COc1ccc(CO)cc1.COc1ccc2c(Cl)cc(Cl)nc2c1C.O.[H-].[Na+]>>COc1ccc(COc2cc(Cl)nc3c(C)c(OC)ccc23)cc1",
        "output": "651"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)N.CCN(CC)CCCNc1nc(-c2cc(C(=O)O)ccc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F>>CCN(CC)CCCNc1nc(-c2cc(C(=O)NC(C)(C)C)ccc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.Cc1c(N2CCNC(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12.Cl.[Na+].[OH-]>>CC(=O)N1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2C)CC1C",
        "output": "369"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN1CCOCC1.Cl.NC1CC1.O=C(O)c1ccc(C(CC2CCOCC2)c2ccc(-c3ncc(CO)s3)[nH]2)cc1.On1nnc2ccccc21>>O=C(NC1CC1)c1ccc(C(CC2CCOCC2)c2ccc(-c3ncc(CO)s3)[nH]2)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.Cl.Nc1ccc(F)cc1F.O.O=Cc1c(O)ccc2c1CCCO2.[BH4-].[Na+]>>Oc1ccc2c(c1CNc1ccc(F)cc1F)CCCO2",
        "output": "359"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccnc2c(C)cccc12.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COc1ccnc2c(CBr)cccc12",
        "output": "625"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.Nc1ccnn1-c1c(Cl)cc(C(F)(F)F)cc1Cl.O=C(Cl)COc1ccc(Cl)cc1Cl.c1ccncc1>>O=C(COc1ccc(Cl)cc1Cl)Nc1ccnn1-c1c(Cl)cc(C(F)(F)F)cc1Cl",
        "output": "527"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN.CN(C)C=O.C[C@]12C[C@H](F)[C@@H]3c4ccc(O)cc4C[C@@H](CCCCCBr)[C@H]3[C@@H]1CC[C@@H]2O.O>>CNCCCCC[C@@H]1Cc2cc(O)ccc2[C@H]2[C@@H](F)C[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12",
        "output": "147"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNCC1.CN(C)C=O.COc1cc2c(Oc3ccc4[nH]c(C)cc4c3)ncnc2cc1OCC1CO1>>COc1cc2c(Oc3ccc4[nH]c(C)cc4c3)ncnc2cc1OCC(O)CN1CCCCC1",
        "output": "76"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cn2c(n1)CN(c1ncc(CC)cn1)CC2.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCc1cnc(N2CCn3cc(CO)nc3C2)nc1",
        "output": "286"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F.O=c1ccn(-c2ccccc2)nc1Cc1cccc(O)c1>>O=c1ccn(-c2ccccc2)nc1Cc1cccc(OS(=O)(=O)C(F)(F)F)c1",
        "output": "843"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C[C@H](NC(=O)c1ccccc1)C(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.ClC(Cl)Cl.ClCCl.NCC1CCCN1Cc1ccc(Cl)cc1.On1nnc2ccccc21>>CC(C)C[C@H](NC(=O)c1ccccc1)C(=O)NCC1CCCN1Cc1ccc(Cl)cc1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)N(CCO[Si](C)(C)C(C)(C)C)C(=O)c1nc(Cc2ccc(Cl)cc2Br)nc(O)c1OCc1ccccc1.CCCCCC.CCOC(C)=O.Cl>>CC(C)N(CCO)C(=O)c1nc(Cc2ccc(Cl)cc2Br)nc(O)c1OCc1ccccc1",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)c1ccccc1.COc1cnc(-c2ccc([N+](=O)[O-])cc2)[nH]c1=O.O=P(Cl)(Cl)Cl>>COc1cnc(-c2ccc([N+](=O)[O-])cc2)nc1Cl",
        "output": "14"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)CCc1ncc(-c2ccc(NC(=O)NC3CCCCC3)cc2)s1.O=C(O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1>>O=C(O)CCc1ncc(-c2ccc(NC(=O)NC3CCCCC3)cc2)s1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.CNOC.COc1cc(C(C)(C)C(=O)O)ccc1F.Cl.ClCCl>>COc1cc(C(C)(C)C(=O)N(C)OC)ccc1F",
        "output": "54"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cc(OC(F)(F)F)cc(N2CCOCC2)c1>>O=C(Cl)c1cc(OC(F)(F)F)cc(N2CCOCC2)c1",
        "output": "448"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(-c5cccc(C#N)c5C)ccc(F)c43)ccc21.O>>Cc1c(C#N)cccc1-c1ccc(F)c2c1CC[C@H]2Oc1ccc2c(c1)OC[C@H]2CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(C)=O.Cl[Sn]Cl.Nc1cc(F)c(Br)cc1[N+](=O)[O-].O.O.O.O=C([O-])O.[Na+]>>Nc1cc(F)c(Br)cc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)CN1CC[C@@H](F)C1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCN1CC[C@@H](F)C1",
        "output": "343"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(C)c(C(C)=O)cc1NC(=O)Oc1ccccc1.Clc1cc(Cl)cc(N2CCNCC2)c1>>COc1cc(C)c(C(C)=O)cc1NC(=O)N1CCN(c2cc(Cl)cc(Cl)c2)CC1",
        "output": "525"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CN(C)C=O.Clc1ccnc2ccc(Br)cc12.[Cl-].[Li]CCCC.[NH4+]>>O=Cc1ccc2nccc(Cl)c2c1",
        "output": "638"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.NC(=O)CC1(O)CCN(Cc2ccccc2)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCCC1(O)CCN(Cc2ccccc2)CC1",
        "output": "112"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)c1ccn(CC(=O)OC(C)(C)C)c1.ClCCl.O=C(O)C(F)(F)F>>CC(C)c1ccn(CC(=O)O)c1",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cc(C)cc(Oc2[nH]c(=O)[nH]c(=O)c2C(C)C)c1.Fc1ccc(F)c(CBr)c1>>Cc1cc(C)cc(Oc2c(C(C)C)c(=O)[nH]c(=O)n2Cc2cc(F)ccc2F)c1",
        "output": "389"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COC(=O)C(Oc1ccc2ncc(Br)cc2c1)SC.Cl.O.[Na+].[OH-]>>CSC(Oc1ccc2ncc(Br)cc2c1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)Oc1cc(Nc2ccnc(Cl)n2)[nH]n1.CC(C)c1cc(CN)on1.CCN(C(C)C)C(C)C.COCCO>>CC(C)Oc1cc(Nc2ccnc(NCc3cc(C(C)C)no3)n2)[nH]n1",
        "output": "544"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCc1ccccc1.CN(C)C=O.NCCCCCCCNc1cccc2c1C(=O)c1cccc3[nH]nc-2c13.O.[Cs+].[OH-]>>NCCCCCCCNc1cccc2c1C(=O)c1cccc3c1c-2nn3Cc1ccccc1",
        "output": "635"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CC(C)(CCS(=O)(=O)CCOCCOCCO)NC(=O)OCc1ccccc1.ClCCl.c1ccncc1>>CC(=O)OCCOCCOCCS(=O)(=O)CCC(C)(C)NC(=O)OCc1ccccc1",
        "output": "254"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(c1cc(N)cc(Br)c1)c1cccc(OC(F)F)c1.O=[N+]([O-])c1cc(Br)cc(S(=O)(=O)N2CCc3ccc(F)cc3C2)c1>>Nc1cc(Br)cc(S(=O)(=O)N2CCc3ccc(F)cc3C2)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(CCCO)CC1.CSc1ccc(O)cc1F>>CSc1ccc(OCCCC2CCN(C(=O)OC(C)(C)C)CC2)cc1F",
        "output": "478"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCCC(N)=NO.O=C(O)C1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)N2CCC(O)CC2)C1>>CCOCCc1noc(C2CC(c3ccc(C(F)(F)F)cc3)CN(C(=O)N3CCC(O)CC3)C2)n1",
        "output": "728"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1nc(N2CCN(CC3CCCCO3)C2=O)sc1C(=O)O.Cc1nc(N2CCN(Cc3ccccc3)C2=O)sc1C(=O)O.NCc1cccnc1>>Cc1nc(N2CCN(CC3CCCCO3)C2=O)sc1C(=O)NCc1cccnc1",
        "output": "534"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CSc1ccccc1.Nc1ncc(F)cc1-c1cc(Cc2ccc(OCc3ccccc3)cc2)no1.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>Nc1ncc(F)cc1-c1cc(Cc2ccc(O)cc2)no1",
        "output": "23"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CC(C)(C)OC(=O)NCCBr.CCCCCC.O.Oc1ccc2c(c1)C(Cc1ccc(Cl)c(Cl)c1)C(N1CCCC1)CC2.[H-].[Na+]>>CC(C)(C)OC(=O)NCCOc1ccc2c(c1)C(Cc1ccc(Cl)c(Cl)c1)C(N1CCCC1)CC2",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O=S(=O)(Cl)c1cccnc1.O=[N+]([O-])c1ccc(N2CCNCC2)cc1.c1ccncc1>>O=[N+]([O-])c1ccc(N2CCN(S(=O)(=O)c3cccnc3)CC2)cc1",
        "output": "169"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)COc1cc2onc(-c3ccccc3F)c2cc1Br.Cl.O.[Na+].[OH-]>>O=C(O)COc1cc2onc(-c3ccccc3F)c2cc1Br",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)c1cc(CNc2ccc(-c3ccccc3)cc2)c(C)o1>>Cc1oc(C(=O)O)cc1CNc1ccc(-c2ccccc2)cc1",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(=O)CCN.CN(C)C=O.Cc1c(C(Nc2ccc(C(=O)O)cc2)C2CCCC2)oc2ccc(F)cc12.Cl.Cl.O.On1nnc2ccccc21.[Cl-].[NH4+]>>CCOC(=O)CCNC(=O)c1ccc(NC(c2oc3ccc(F)cc3c2C)C2CCCC2)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)ON=c1cc(-c2cc3ccccc3cn2)oc2cc(C#CCCO)ccc12.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.[Na]>>CC(C)(C)O/N=c1\\cc(-c2cc3ccccc3cn2)oc2cc(C#CCCOS(C)(=O)=O)ccc12",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cc(Cc2cnc(N)nc2N)cc(OC)c1N.Cl.Cl.Cl.O.O=C([O-])O.O=N[O-].[N-]=[N+]=[N-].[Na+].[Na+].[Na+]>>COc1cc(Cc2cnc(N)nc2N)cc(OC)c1N=[N+]=[N-]",
        "output": "189"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[O-].CN(C)C=O.COC(=O)c1ccc(Br)c(Cl)n1.Cl.O.OCCF.[Li+]>>COC(=O)c1ccc(Br)c(OCCF)n1",
        "output": "433"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CN.N#Cc1ccc(Cl)c([N+](=O)[O-])c1>>CNc1ccc(C#N)cc1[N+](=O)[O-]",
        "output": "304"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.Nc1cccc2c1CC(O)C(=O)N2.O=C=NCc1ccc(C(F)(F)F)cc1>>O=C(NCc1ccc(C(F)(F)F)cc1)Nc1cccc2c1CC(O)C(=O)N2",
        "output": "888"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(Cn2nc(C)c3cc(-c4cnn(C)c4)cnc32)cc1.ClC(Cl)Cl.O=C(O)C(F)(F)F>>Cc1n[nH]c2ncc(-c3cnn(C)c3)cc12",
        "output": "978"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Br.CCN(CC)CC.CO.NCCCN1CCOCC1.Nc1ncc(Br)cc1C=O.[BH4-].[Na+]>>Nc1ncc(Br)cc1CNCCCN1CCOCC1",
        "output": "441"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCN1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)c1ccncc1.CNC(=O)c1cnc(Cl)cc1-c1ccccc1C>>CNC(=O)c1cnc(N2CCOCC2)cc1-c1ccccc1C",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNC1.CC(C)n1nc(-c2c(-c3ccccc3)nn3ccc(C(=O)O)cc23)ccc1=O.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.On1nnc2ccccc21>>CC(C)n1nc(-c2c(-c3ccccc3)nn3ccc(C(=O)N4CCCC4)cc23)ccc1=O",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc2cc[nH]c2cc1Cl.Cl.O.O=C1CCNCC1>>COc1cc2c(C3=CCNCC3)c[nH]c2cc1Cl",
        "output": "607"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCS(=O)(=O)N(COCC[Si](C)(C)C)c1nc2ccccc2nc1OC(c1cc[n+]([O-])cc1)C(F)(F)F.CN(C)C(=O)Cl.C[Si](C)(C)C#N.ClCCl.O.O=C([O-])O.[Na+]>>CCCS(=O)(=O)N(COCC[Si](C)(C)C)c1nc2ccccc2nc1OC(c1ccnc(C#N)c1)C(F)(F)F",
        "output": "720"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCNC(=O)Cc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12.ClCCl.O=C(O)C(F)(F)F>>NCCNC(=O)Cc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br.COc1cc(-c2cc(Cl)ccc2C#N)c(OCC(F)(F)F)cn1.c1cc[nH+]cc1>>N#Cc1ccc(Cl)cc1-c1cc(=O)[nH]cc1OCC(F)(F)F",
        "output": "758"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "B.C1CCOC1.C1CCOC1.CCN(C(=O)CCc1ccccc1)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1Cl>>CCN(CCCc1ccccc1)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1Cl",
        "output": "112"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)S(=O)(=O)Cl.CCN(CC)CC.Cl.ClCCl.O=S(=O)(c1ccccc1)n1cc(-c2cnn(C3CCNCC3)c2)c2ccc(F)cc21>>CC(C)S(=O)(=O)N1CCC(n2cc(-c3cn(S(=O)(=O)c4ccccc4)c4cc(F)ccc34)cn2)CC1",
        "output": "584"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)C[AlH]CC(C)C.CCOC(=O)CCc1cn(-c2ccc(C(C)C)cc2)c2cnc(-c3c(CC)cccc3CC)cc12.ClCCl.O=C([O-])[C@H](O)[C@@H](O)C(=O)[O-].[K+].[Na+]>>CCc1cccc(CC)c1-c1cc2c(CCCO)cn(-c3ccc(C(C)C)cc3)c2cn1",
        "output": "225"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.Cl.OC1CCC1.c1ccncc1>>Cc1ccc(S(=O)(=O)OC2CCC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.NCc1ccccc1.O=C(n1ccnc1)n1ccnc1.O=C1CC(C(=O)O)C1>>O=C1CC(C(=O)NCc2ccccc2)C1",
        "output": "599"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CN(C)c1cc(CO)cc(C(C)(C)O[SiH2]C(C)(C)C)c1.ClCCl.O=C([O-])O.[Na+]>>CN(C)c1cc(C=O)cc(C(C)(C)O[SiH2]C(C)(C)C)c1",
        "output": "179"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Cl.Nc1ccc(N2CCOCC2)cc1.O=C(Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Cl)n2)c1)c1c(F)cccc1F>>O=C(Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c1)c1c(F)cccc1F",
        "output": "808"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C[C@@H](O)CN.N#Cc1cnc2cnc(F)cc2c1Nc1ccc(F)c(Cl)c1>>C[C@@H](O)CNc1cc2c(Nc3ccc(F)c(Cl)c3)c(C#N)cnc2cn1",
        "output": "810"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.Nc1ncnc2c1c(-c1cc(OCC3CCCO3)ccc1F)cn2[C@@H]1CC[C@@H](O)CC1>>CS(=O)(=O)O[C@@H]1CC[C@@H](n2cc(-c3cc(OCC4CCCO4)ccc3F)c3c(N)ncnc32)CC1",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1ccc(CNC(=O)c2cc(C(=O)NCc3ccc4c(c3)CCO4)ncn2)cc1.O.[Na+].[OH-]>>O=C(O)c1ccc(CNC(=O)c2cc(C(=O)NCc3ccc4c(c3)CCO4)ncn2)cc1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.N#CC[C@@H](O)c1cccc(OCC2CCOCC2)c1>>NCC[C@@H](O)c1cccc(OCC2CCOCC2)c1",
        "output": "246"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1ncc2c(ccn2Cc2ccccc2OC)c1O.CO.C[O-].NCC(=O)O.[Na+]>>COc1ccccc1Cn1ccc2c(O)c(C(=O)NCC(=O)O)ncc21",
        "output": "977"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(Br)cc1Cc1cc2cc(O)ccc2s1.FCCBr>>Cc1ccc(Br)cc1Cc1cc2cc(OCCF)ccc2s1",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.COCCC1CNC(C(c2ccccc2)c2ccccc2)C1N.COc1ccc(C(C)C)cc1C=O.[Na+]>>COCCC1CNC(C(c2ccccc2)c2ccccc2)C1NCc1cc(C(C)C)ccc1OC",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])cn2)CC1.CO.[Pd]>>CC(C)(C)OC(=O)N1CCN(c2ccc(N)cn2)CC1",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.Nc1cc(Cl)cc(C(F)(F)F)c1>>CC(C)(C)OC(=O)Nc1cc(Cl)cc(C(F)(F)F)c1",
        "output": "735"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCN(C(C)C)C(C)C.ClCCl.N#Cc1ccc(Cl)nn1.NC1CCN(Cc2cc(F)c(F)c(F)c2)CC1.O.O=C([O-])[O-].[Na+].[Na+]>>N#Cc1ccc(NC2CCN(Cc3cc(F)c(F)c(F)c3)CC2)nn1",
        "output": "241"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)CCSCC(=O)c1ccc2[nH]c(=O)[nH]c2c1.[Na+].[OH-]>>O=C(O)CCSCC(=O)c1ccc2[nH]c(=O)[nH]c2c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.O=C(c1cccc(F)c1)c1ccc2cccnc2c1[N+](=O)[O-].[Pd]>>Nc1c(C(=O)c2cccc(F)c2)ccc2cccnc12",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.O=C(O)CCC1OCCc2ccccc21.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCC1OCCc2ccccc21",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCl.OB(O)c1ccccc1.Oc1ccc(Br)c(F)c1F>>Fc1c(Br)ccc(Oc2ccccc2)c1F",
        "output": "920"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CC(=O)c1cnc(OCC(F)(F)F)c(CO)c1.CCN(CC)CC.ClCCl.O>>CC(=O)OCc1cc(C(C)=O)cnc1OCC(F)(F)F",
        "output": "254"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)/C(=N\\OC)c1ccc(OCCOc2ccc3ccccc3c2)s1.CO.[Na+].[OH-]>>CO/N=C(\\C(=O)O)c1ccc(OCCOc2ccc3ccccc3c2)s1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.C[O-].ClCCl.O=C(O)c1ccccc1S(=O)(=O)N1CCOCC1.O=S(Cl)Cl.[Na+]>>O=C(Cl)c1ccccc1S(=O)(=O)N1CCOCC1",
        "output": "3"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2ccc(NCC3CCN(CC(C)(C)C(F)(F)F)CC3)cc2)cc1.O.[Li]O>>CC(C)(CN1CCC(CNc2ccc(-c3ccc(C(=O)O)cc3)cc2)CC1)C(F)(F)F",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.CCc1noc(-c2ccc(Br)cc2)c1NC(=O)OC(C)(C)C>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(CC)c4NC(=O)OC(C)(C)C)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC[C@H](C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC.CO.Cl.O.[K+].[OH-]>>CC[C@H](C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Oc1ccc(N2C(=O)c3ccccc3C2=O)c(N)c1.CO.ClCCl.ClCCl.O=C(O)C1CCN(c2ccncc2)CC1.O=S(Cl)Cl.c1ccncc1>>CC(C)(C)[Si](C)(C)Oc1ccc(N2C(=O)c3ccccc3C2=O)c(NC(=O)C2CCN(c3ccncc3)CC2)c1",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(-c2ccc3c(=O)c(C(=O)OCC)cn(CC)c3c2)cn1.CO.[K+].[OH-]>>CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(-c2ccc3c(=O)c(C(=O)O)cn(CC)c3c2)cn1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)C1(c2cnc(C)nc2)CCOCC1.CCO.N.[BH3-]C#N.[Na+]>>Cc1ncc(C2(C(C)N)CCOCC2)cn1",
        "output": "63"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1cccc(NC(=O)Nc2cccc(-c3c(C(=O)c4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)c1.[Li+].[OH-]>>O=C(Nc1cccc(C(=O)O)c1)Nc1cccc(-c2c(C(=O)c3ccccc3)cnc3c(C(F)(F)F)cccc23)c1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COC(=O)CCCCCCCBr.O=c1[nH]c(-c2ccccc2)c(-c2ccccc2)n1-c1ccccc1.[H-].[Na+]>>COC(=O)CCCCCCCn1c(-c2ccccc2)c(-c2ccccc2)n(-c2ccccc2)c1=O",
        "output": "495"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.COc1c(CO)cc(C(C)(C)C)cc1C(C)(C)C.Cl.ClCCl.O.O=C1CCNCC1C(c1ccc(F)cc1)c1ccc(F)cc1>>COc1c(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc(C(C)(C)C)cc1C(C)(C)C",
        "output": "765"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N(C)C.CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COC(=O)[C@@]12C[C@H]1C=CCCCCC[C@H](N)C(=O)N1C[C@H](Oc3nc(-c4ccccn4)nc4ccsc34)C[C@H]1C(=O)N2.F[P-](F)(F)(F)(F)F.O=C(O)CC1CC1.O=C([O-])O.[Na+]>>COC(=O)[C@@]12C[C@H]1C=CCCCCC[C@H](NC(=O)CC1CC1)C(=O)N1C[C@H](Oc3nc(-c4ccccn4)nc4ccsc34)C[C@H]1C(=O)N2",
        "output": "133"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc(N)ccc1N1CCOCC1.N#Cc1cc(-c2ccnc(Cl)n2)ccc1OC1CCOCC1>>Cc1cc(Nc2nccc(-c3ccc(OC4CCOCC4)c(C#N)c3)n2)ccc1N1CCOCC1",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.O=C(Cl)CC1CCOCC1.O=C([O-])O.O=c1cc(O)c2cccnc2n1-c1ccccc1.[H-].[H][H].[Na+].[Na+]>>O=C(CC1CCOCC1)Oc1cc(=O)n(-c2ccccc2)c2ncccc12",
        "output": "111"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCC(CNCCC2CCCNC2)C1.CC#N.O=C1Nc2ccccc2N(C(=O)Cl)c2ncccc21>>O=C1Nc2ccccc2N(C(=O)N2CCCC(CCNCC3CCCC3)C2)c2ncccc21",
        "output": "258"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cnn(Cc2ccc(Cn3cccn3)c(OC)c2)c1.O>>COc1cc(Cn2cc(C(=O)O)cn2)ccc1Cn1cccn1",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.N#Cc1ccc2cc(O)ccc2c1.O=C1CCC(=O)N1Cl.[Cl-].[Cl-].[Cl-].[Cl-].[Zr+4]>>N#Cc1ccc2c(Cl)c(O)ccc2c1",
        "output": "121"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.O.O=C(CCl)NCc1ccccc1.O=C([O-])[O-].[Na+].[Na+].c1ccc(N2CCNCC2)nc1>>O=C(CN1CCN(c2ccccn2)CC1)NCc1ccccc1",
        "output": "340"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)c1ccc(N=C=O)cc1.NCc1ccc2c(c1)CN(C(=O)[C@H](N)Cc1ccc(Cl)cc1Cl)C2>>CN(C)c1ccc(NC(=O)NCc2ccc3c(c2)CN(C(=O)[C@H](N)Cc2ccc(Cl)cc2Cl)C3)cc1",
        "output": "814"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=CCOC(=O)N1C[C@H](O)C[C@H]1C(=O)OC.CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@@H](O)CN1C(=O)OCc1ccccc1.CCO.CCOC(C)=O.ClC(Cl)Cl.[Pd]>>CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@@H](O)CN1",
        "output": "428"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1cc(C)c(Cl)cn1.O=C1CCC(=O)N1Br.O=S([O-])([O-])=S.[Na+].[Na+]>>COc1ncc(Cl)c(C)c1Br",
        "output": "518"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOc1cc(C2CCC2)c(C2CC2)cc1C(=O)OC.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>CCOc1cc(C2CCC2)c(C2CC2)cc1CO",
        "output": "444"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.Cl.Nc1ncccc1F.O=C1CCC(=O)N1Br>>Nc1ncc(Br)cc1F",
        "output": "518"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(C)=O.CNC.Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(S(=O)(=O)Cl)c3)n2)n1>>Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2cccc(-c3cccc(S(=O)(=O)N(C)C)c3)n2)n1",
        "output": "99"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CO.Cl.N[C@@H]1Cc2ccccc2[C@@H](Cl)[C@@H]1O>>CC(C)(C)OC(=O)N[C@@H]1Cc2ccccc2[C@@H](Cl)[C@@H]1O",
        "output": "631"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.ClCCl.O=C(O)c1cc([N+](=O)[O-])ccc1F.[NH3+]c1cccc(F)c1>>O=C(Nc1cccc(F)c1)c1cc([N+](=O)[O-])ccc1F",
        "output": "50"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.COC(=O)Cc1cccc(O)c1.Cc1oc(-c2ccccc2)nc1COc1cc(CCl)ccn1.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)Cc1cccc(OCc2ccnc(OCc3nc(-c4ccccc4)oc3C)c2)c1",
        "output": "49"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC1(C)OB(O)c2ccc(CN)cc21.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)n2cccc12>>CC1(C)OB(O)c2ccc(CNC(=O)c3ccc(C4=NOC(c5cc(Cl)c(Cl)c(Cl)c5)(C(F)(F)F)C4)n4cccc34)cc21",
        "output": "790"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)Nc1cc(C(=O)O)cc(-c2cnc(Nc3ccc(F)c(Cl)c3)nc2N2CCOCC2)c1.Cl>>Nc1cc(C(=O)O)cc(-c2cnc(Nc3ccc(F)c(Cl)c3)nc2N2CCOCC2)c1",
        "output": "782"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.Cn1nc(-c2cncnc2)nc1-c1ccc2c(c1)cc(-c1c(F)cccc1Cl)n2C(=O)OC(C)(C)C.O=C(O)C(F)(F)F.[NH4+].[OH-]>>Cn1nc(-c2cncnc2)nc1-c1ccc2[nH]c(-c3c(F)cccc3Cl)cc2c1",
        "output": "848"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCCCCCCCc1ccc2[nH]ccc2c1.CCOCC>>CCCCCCCCc1ccc2c(c1)CCN2",
        "output": "672"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.ClCCl.N#Cc1ccccc1N1CCNCC1.O.O=C=Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1>>N#Cc1ccccc1N1CCN(C(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1",
        "output": "323"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CI.COC(=O)c1c(C(F)F)nc(C(F)(F)F)c(C(O)c2ccns2)c1CC(C)C>>COC(=O)c1c(C(F)F)nc(C(F)(F)F)c(C(OC)c2ccns2)c1CC(C)C",
        "output": "140"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Oc1ccccc1C#Cc1ccc2ccccc2n1.CO.Cl.O.O=C([O-])[O-].[K+].[K+]>>Oc1ccccc1C#Cc1ccc2ccccc2n1",
        "output": "22"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)c1cc(OCC)c(Br)c(OCC)c1.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[H-].[Na+].[Na+]>>CCOc1cc(CO)cc(OCC)c1Br",
        "output": "311"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)CC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1.[Na+].[OH-]>>O=C(O)CC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN=C=NCCCN(C)C.Cl.ClCCl.O=C(O)c1cc2cccc([N+](=O)[O-])c2[nH]1>>CC(C)(C)OC(=O)N1CCN(C(=O)c2cc3cccc([N+](=O)[O-])c3[nH]2)CC1",
        "output": "605"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)/N=N/C(=O)OCC.Cc1cc(O)cc(O)c1.N#Cc1ccc(CCO)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(O)cc(OCCc2ccc(C#N)cc2)c1",
        "output": "550"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)CNC(=O)C1=C(O)c2c(Cl)cccc2C(C)(C)C1=O.O.O=C(O)C(F)(F)F>>CC1(C)C(=O)C(C(=O)NCC(=O)O)=C(O)c2c(Cl)cccc21",
        "output": "278"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.NN.O.O=[N+]([O-])c1ccc2[nH]nc(/C=C/c3cccnc3)c2c1.[C].[Pd]>>Nc1ccc2[nH]nc(/C=C/c3cccnc3)c2c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(CC)(COC(C)=O)COc1cccc(N)c1C#N.NS(=O)(=O)Cl>>CCC(CC)(COC(C)=O)COc1cccc(NS(N)(=O)=O)c1C#N",
        "output": "395"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOc1cc(Cc2cnc(N)nc2N)cc(O)c1-c1cccc(N)c1.COc1ccc(S(=O)(=O)Cl)cc1F>>CCOc1cc(Cc2cnc(N)nc2N)cc(OS(=O)(=O)c2ccc(OC)c(F)c2)c1-c1cccc(N)c1",
        "output": "380"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)COc1ccc(Cl)c2nc(C)c(Cc3ccc(Cl)cc3)c(OC)c12.O.[Li+].[OH-]>>COc1c(Cc2ccc(Cl)cc2)c(C)nc2c(Cl)ccc(OCC(=O)O)c12",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.C[C@@H]1CN(Cc2cccc([N+](=O)[O-])c2Cl)C[C@H](C)N1.ClCCl.O=C(Cl)C1CCCC1>>C[C@@H]1CN(Cc2cccc([N+](=O)[O-])c2Cl)C[C@H](C)N1C(=O)C1CCCC1",
        "output": "125"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC(CC(=O)O)c1ccsc1.CN(C)c1ccncc1.ClCCCl.Nc1ccc2cnccc2c1.c1ccncc1>>CC(C)(C)OC(=O)NC(CC(=O)Nc1ccc2cnccc2c1)c1ccsc1",
        "output": "365"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.CCO.C[Si](C)(C)CCOCn1nccc1-c1cnc2c(NCCCOP(=O)(OCc3ccccc3)OCc3ccccc3)nc3cc(C(F)(F)F)ccc3n12.Cl.[Na]>>O=P(OCCCNc1nc2cc(C(F)(F)F)ccc2n2c(-c3ccn[nH]3)cnc12)(OCc1ccccc1)OCc1ccccc1",
        "output": "813"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.CN[C@@H]1CN(Cc2ccccc2)C[C@H]1c1ccc(Cl)c(Cl)c1.ClCCl>>CN(C(=O)OC(C)(C)C)[C@@H]1CN(Cc2ccccc2)C[C@H]1c1ccc(Cl)c(Cl)c1",
        "output": "694"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCCCC(F)(F)F>>CS(=O)(=O)OCCCC(F)(F)F",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)CCBr.CN(C)C=O.O=C([O-])[O-].O=c1c2cc(-c3ccc(Cl)cc3)oc2ccn1-c1cccc(O)c1.[K+].[K+]>>CC(C)(C)CCOc1cccc(-n2ccc3oc(-c4ccc(Cl)cc4)cc3c2=O)c1",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.C[O-].O.O=[N+]([O-])c1cc(Cl)c(Br)cc1F.[Na+]>>COc1cc(Br)c(Cl)cc1[N+](=O)[O-]",
        "output": "485"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CCC(=O)c1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C.CCO.Cl.NO.[Na+]>>CCC(=NO)c1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C",
        "output": "212"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCS3(=O)=O)cc1.COCCOC.Cl>>CCc1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCS3(=O)=O)cc1",
        "output": "58"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCO.NCc1ccccc1.Nc1nc(Cl)nc2c1ncn2Cc1ccccc1.[Na+].[OH-]>>Nc1nc(NCc2ccccc2)nc2c1ncn2Cc1ccccc1",
        "output": "364"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(O)CN.CCCCn1c(=O)c(C(=O)OCC)c(O)c2ncc(Cc3ccc(F)cc3)cc21>>CCCCn1c(=O)c(C(=O)NCC(C)O)c(O)c2ncc(Cc3ccc(F)cc3)cc21",
        "output": "498"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.Cl.O.O=C([O-])[O-].[K+].[K+].c1cncc(N2CCC3(CC2)OCCO3)c1>>O=C1CCN(c2cccnc2)CC1",
        "output": "251"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClC(Cl)Cl.II.OCc1ccc2c(c1)OCO2>>OCc1cc2c(cc1I)OCO2",
        "output": "372"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Cl.O=C(c1ccc2cc(Cl)ccc2c1)C1CCNCC1.[BH4-].[Na+]>>OC(c1ccc2cc(Cl)ccc2c1)C1CCNCC1",
        "output": "24"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CS(=O)(=O)c1cc(F)cc([N+](=O)[O-])c1.CS(C)=O.O>>CS(=O)(=O)c1cc(N2CCOCC2)cc([N+](=O)[O-])c1",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CNOC.Cl.O.O=C(O)Cc1ccccc1.[Na+].[OH-]>>CON(C)C(=O)Cc1ccccc1",
        "output": "54"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCBr.CN(C)C=O.O=C([O-])[O-].Oc1ccc(-c2c3nc(c(-c4ccc(O)cc4)c4ccc([nH]4)c(-c4ccc(O)cc4)c4nc(c(-c5ccc(O)cc5)c5ccc2[nH]5)C=C4)C=C3)cc1.[K+].[K+]>>CCCCCCCCCCOc1ccc(-c2c3nc(c(-c4ccc(O)cc4)c4ccc([nH]4)c(-c4ccc(O)cc4)c4nc(c(-c5ccc(O)cc5)c5ccc2[nH]5)C=C4)C=C3)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C#N)(CC2CC2)CC1.CCO.CCO.O.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(CN)(CC2CC2)CC1",
        "output": "246"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CS(=O)(=O)c1ccccc1.CC#N.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.Cc1ccc(S(=O)(=O)n2ccc3cc(Br)ccc32)cc1.[Pd+2]>>Cc1ccc(S(=O)(=O)n2ccc3cc(/C=C/S(=O)(=O)c4ccccc4)ccc32)cc1",
        "output": "539"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC[C@H](C)N.Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)O)cn2)c1O>>CC[C@H](C)NC(=O)c1ccc(-n2ncc(-c3ccc(C#N)cc3C)c2O)nc1",
        "output": "674"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CCOCC.COCCCO.O.O=C(Cl)OCCl.c1ccncc1>>COCCCOC(=O)OCCl",
        "output": "144"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1cccc(-c2nc(-c3ccccc3)cc(-c3ccccc3)n2)c1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)[O-].CC1(C)c2ccccc2-c2cc3c(cc21)[nH]c1ccc(Br)cc13.Cc1ccc(C)cc1.[Na+].[Pd+2]>>CC1(C)c2ccccc2-c2cc3c4cc(Br)ccc4n(-c4cccc(-c5nc(-c6ccccc6)cc(-c6ccccc6)n5)c4)c3cc21",
        "output": "349"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.C[O-].O=C(O)c1cccnc1.O=C([O-])O.O=[N+]([O-])c1ccc(CBr)cc1.[Na+].[Na+]>>O=C(OCc1ccc([N+](=O)[O-])cc1)c1cccnc1",
        "output": "403"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)C=O.COc1ccc(CN2CCc3cc(CC(N)=O)ccc3C2=O)cc1.Clc1nc(Cl)nc(Cl)n1>>COc1ccc(CN2CCc3cc(CC#N)ccc3C2=O)cc1",
        "output": "172"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COCC(N)=NO.O=C(O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)N2CCOCC2)C1>>COCc1noc(C2CC(c3ccc(OC(F)(F)F)cc3)CN(C(=O)N3CCOCC3)C2)n1",
        "output": "728"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.COc1ccc(C=O)cc1.NNc1nc(N)nc2[nH]cnc12>>COc1ccc(C=NNc2nc(N)nc3[nH]cnc23)cc1",
        "output": "167"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc2cc(Br)ccc2c1.CO.COCCOC.Cc1ccccc1.O=C([O-])[O-].OB(O)c1ccc2c3c(cccc13)-c1c-2c(-c2ccccc2)c2ccccc2c1-c1ccccc1.c1ccc([PH](c2ccccc2)(c2ccccc2)[Pd]([PH](c2ccccc2)(c2ccccc2)c2ccccc2)([PH](c2ccccc2)(c2ccccc2)c2ccccc2)[PH](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Brc1ccc2cc(-c3ccc4c5c(cccc35)-c3c-4c(-c4ccccc4)c4ccccc4c3-c3ccccc3)ccc2c1",
        "output": "837"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=[N+]([O-])c1ccc(C2CCC2)cc1F.[H][H].[Pd]>>Nc1ccc(C2CCC2)cc1F",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1[C@@H](Cc2ccc(O)cc2)COC1(C)C.CS(C)=O.NC(=O)c1ccnc(Cl)c1.O.[K+].[OH-]>>CC(C)(C)OC(=O)N1[C@@H](Cc2ccc(Oc3cc(C(N)=O)ccn3)cc2)COC1(C)C",
        "output": "516"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCCBr.CC(C)(C)OC(=O)NCCc1ccc(O)cc1.CCOC(C)=O.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)NCCc1ccc(OCCBr)cc1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)c1cc2n(n1)CCOC2.ClCCl.[Cl-].[H-].[NH4+]>>OCc1cc2n(n1)CCOC2",
        "output": "391"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C(=N)N(C)C.CN1CCNCC1.CS(C)=O.Cc1ccccc1C1CCN(S(=O)(=O)c2cccc(F)n2)CC1>>Cc1ccccc1C1CCN(S(=O)(=O)c2cccc(N3CCN(C)CC3)n2)CC1",
        "output": "756"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[O-].CS(C)=O.N#Cc1cc([N+](=O)[O-])ccc1F.Nc1ccccc1-c1ccccc1.O.[K+]>>N#Cc1cc([N+](=O)[O-])ccc1Nc1ccccc1-c1ccccc1",
        "output": "609"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.CN1CCNCC1.COc1cc(F)ccc1[N+](=O)[O-]>>COc1cc(N2CCN(C)CC2)ccc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)c(C)cc1[N+](=O)[O-].C[O-].ClCCl.O=C(O)C(F)(F)F.[Na+]>>COc1cc(N2CCNCC2)c(C)cc1[N+](=O)[O-]",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.O=C(O)c1cc(Br)ncc1F.O=S(Cl)Cl>>CCOC(=O)c1cc(Br)ncc1F",
        "output": "33"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN.COC(=O)C(SCCCl)SCCCl.C[Al](C)C.Cl.c1ccccc1>>CNC(=O)C(SCCCl)SCCCl",
        "output": "392"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CC(=O)OC12CC3CC(CC(O)(C3)C1)C2.CCN(CC)CC.CS(=O)(=O)Cl.Cc1ccccc1.O.O=S(=O)([O-])[O-].[Mg+2]>>C=CC(=O)OC12CC3CC(C1)CC(OS(C)(=O)=O)(C3)C2",
        "output": "0"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)[C@@H](NC(=O)OC(C)(C)C)C(=O)O.CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5)cn3)nc2n1C1CCCC1>>CC(C)[C@@H](NC(=O)OC(C)(C)C)C(=O)N1C2CCC1CN(C(=O)c1ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc1)C2",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCCCCCCCC#CC#CCCCCCCCCC(=O)O.CO.ClC(Cl)Cl.O=S(=O)(O)O>>CCCCCCCCCCCCC#CC#CCCCCCCCCC(=O)OC",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#CCCCCO.CC(C)(C)OC(=O)N1CC[C@H]1COc1cncc(Br)c1.COCCOC.O.O=C([O-])[O-].[Cu]I.[K+].[K+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CC[C@H]1COc1cncc(C#CCCCCO)c1",
        "output": "719"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCC.CCN(CC)CC.CCOCC.CC[C@@H](CO)NC(c1ccccc1)(c1ccccc1)c1ccccc1.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC[C@@H](C=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(CCCN(Cc2nccc3c4ccccc4n(CC(=O)N4CCOCC4)c23)[C@H]2CCCc3cccnc32)CC1.ClCCl.O.O=C(O)C(F)(F)F.[Na+].[OH-]>>O=C(Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21)N1CCOCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)C1CC2(CN)CCC1(C(N)=O)CC2.CO.ClC(Cl)Cl.ClCCl.O.O.c1ccncc1>>CC(C)(C)OC(=O)C1CC2(CN)CCC1(C#N)CC2",
        "output": "172"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc2sc(S(=O)(=O)Cl)cc2c1.Nc1cccc(C(=O)O)c1.c1ccncc1>>Cc1ccc2sc(S(=O)(=O)Nc3cccc(C(=O)O)c3)cc2c1",
        "output": "861"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCC=CC1(c2cc(OC)cc(OC)c2)CCCC1.CCOC(C)=O.[Pd]>>CCCCCCC1(c2cc(OC)cc(OC)c2)CCCC1",
        "output": "143"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "NCCCCn1cnc2c(N)nc3ccccc3c21.O=C(Cl)c1cn(Cc2ccccc2)c2ccccc12>>Nc1nc2ccccc2c2c1ncn2CCCCNC(=O)c1cn(Cc2ccccc2)c2ccccc12",
        "output": "353"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1cccc(C)c1CNc1nc(C(=O)O)cc2c1nc(C)n2C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClCCl.F[B-](F)(F)F.N.O>>CCc1cccc(C)c1CNc1nc(C(N)=O)cc2c1nc(C)n2C",
        "output": "136"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCCCCCCCCCCCCCOc1cccc(C(=O)OC)c1.CCO.Cl.O.[Na+].[OH-]>>CCCCCCCCCCCCCCCOc1cccc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCC.CCO.CCOC(C)=O.COc1ccc(NS(=O)(=O)c2ccccc2[N+](=O)[O-])cc1OC.Cl[Sn]Cl>>COc1ccc(NS(=O)(=O)c2ccccc2N)cc1OC",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1=COCCC1.CC(=O)c1ccc(O)cc1.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O>>CC(=O)c1ccc(OC2CCCCO2)cc1",
        "output": "319"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.CC(C)=CCCC(C)=CCCC(C)C(O)CCC(C)=CCCC(C)=CCO.c1ccncc1>>CC(=O)OCC=C(C)CCC=C(C)CCC(O)C(C)CCC=C(C)CCC=C(C)C",
        "output": "155"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOc1cc(-c2ccc(F)cc2)c(C2CC2)cc1CO.Cc1ccccc1.[Mn+4].[O-2].[O-2]>>CCOc1cc(-c2ccc(F)cc2)c(C2CC2)cc1C=O",
        "output": "179"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "N#Cc1ccccc1OCC1CO1.NCCc1nc2ccc(C3=NNC(=O)CC3)cc2[nH]1>>N#Cc1ccccc1OCC(O)CNCCc1nc2ccc(C3=NNC(=O)CC3)cc2[nH]1",
        "output": "16"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cl.Cl.O=C(c1cc(Cl)ncn1)N1CCC2CCCCC21.O=c1[nH]c2ncccc2n1C1CCNCC1>>O=C(c1cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)ncn1)N1CCC2CCCCC21",
        "output": "162"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O=C([O-])[O-].O=C1Nc2cccnc2N(C(=O)CCl)c2ccccc21.OCCCN1CCNCC1.[Na+].[Na+]>>O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCO)CC2)c2ccccc21",
        "output": "340"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C(NCc1csc(N2CC(O)C2)n1)c1ccccc1.c1ccncc1>>CS(=O)(=O)OC1CN(c2nc(CNC(=O)c3ccccc3)cs2)C1",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.CCN(C(C)C)C(C)C.CCOC(C)=O.CS(=O)(=O)Cl.ClCCl.O.[Cl-].[Na+]>>CC(OS(C)(=O)=O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C[C@@H]1C[C@H](O)C[C@H]2CC(CO)=C[C@@]12C.ClCCl.O=[Mn]=O>>C[C@@H]1C[C@H](O)C[C@H]2CC(C=O)=C[C@@]12C",
        "output": "183"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCC[C@H](O)COCc1ccccc1.CI.CN(C)C=O.[H-].[Na+]>>C=CCC[C@@H](COCc1ccccc1)OC",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCc1ccccc1.CC(C)(C)c1ccc(O)c(C(C)(C)CCO)c1.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)c1ccc(OCc2ccccc2)c(C(C)(C)CCO)c1",
        "output": "127"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(CNCCNC(=O)c2sccc2Nc2ccnc3[nH]ccc23)cc1.NC1CCN(C(=O)c2sccc2Nc2ccnc3[nH]ccc23)CC1.O=Cc1ccccc1>>O=C(c1sccc1Nc1ccnc2[nH]ccc12)N1CCC(NCc2ccccc2)CC1",
        "output": "468"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C(=O)Cl)C1CC1.CC(C(=O)Oc1ccc(C(=O)CNC(C)(C)C)cc1OC(=O)C(C)C1CC1)C1CC1>>CC(C(=O)Oc1ccc(C(O)CNC(C)(C)C)cc1OC(=O)C(C)C1CC1)C1CC1",
        "output": "24"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1CN(Cc2ccccc2)CC(C)C1O.CO.[H][H].[OH-].[OH-].[Pd+2]>>CC1CNCC(C)C1O",
        "output": "84"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CCN(Cc2ccc(C(=O)O)cc2)CC1.CO.C[Si](C)(C)C=[N+]=[N-].Cc1ccccc1.ClCCl>>COC(=O)c1ccc(CN2CCN(C)CC2)cc1",
        "output": "195"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC1(C)CN(Cc2ccccc2)CCC1N.CO.[H][H].[OH-].[OH-].[Pd+2]>>CCC1(C)CNCCC1N",
        "output": "84"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCN(CC)CC.COc1ccccc1N1CCNCC1.CS(=O)(=O)OCC1CCCN(C(=O)C2(c3ccc(Cl)cc3)CCC2)C1>>COc1ccccc1N1CCN(CC2CCCN(C(=O)C3(c4ccc(Cl)cc4)CCC3)C2)CC1",
        "output": "496"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)(CCl)c1ccccc1.CC1NCC(C)(C)c2ccccc21.ClCCl.O=C(Cl)C(Cl)Cl.[Na+].[OH-].c1ccc2cnccc2c1>>CC1c2ccccc2C(C)(C)CN1C(=O)C(Cl)Cl",
        "output": "240"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCOC(=O)N1CCN(C(=O)CNC(=O)c2cc(OCC(=O)OCc3ccccc3)c3ccccc3n2)CC1.CCOC(C)=O.CN(C)C=O>>CCCCOC(=O)N1CCN(C(=O)CNC(=O)c2cc(OCC(=O)O)c3ccccc3n2)CC1",
        "output": "186"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CBr.CN(C)C=O.Cc1ccc(Sc2c(C)[nH]c3c2C(=O)CC(C)(C)C3)cc1.[H-].[Na+]>>CCOC(=O)Cn1c(C)c(Sc2ccc(C)cc2)c2c1CC(C)(C)CC2=O",
        "output": "310"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.CI.N#Cc1ccc([N+](=O)[O-])[nH]1.O=C([O-])[O-].[K+].[K+]>>Cn1c(C#N)ccc1[N+](=O)[O-]",
        "output": "191"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CCC(C)(C(=O)c1ccc(F)cc1)N(C)C.CC(=O)N(C)C.O=C([O-])[O-].SCCCS.[K+].[K+]>>C=CCC(C)(C(=O)c1ccc(SCCCS)cc1)N(C)C",
        "output": "503"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)OB(OC(C)C)OC(C)C.CCCCC.CCOCC.Cl.FC1(F)Oc2ccc(Br)cc2O1.[Li]C(C)(C)C.[Na+].[OH-]>>OB(O)c1ccc2c(c1)OC(F)(F)O2",
        "output": "832"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCC(=O)O.Cc1cccc(C)c1N>>COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCC(=O)Nc1c(C)cccc1C",
        "output": "365"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.COc1cc([N+](=O)[O-])ccc1Br.O.[Fe]>>COc1cc(N)ccc1Br",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O=[N+]([O-])c1ccc(N2CCCC2)cc1C(F)(F)F.[Pd]>>Nc1ccc(N2CCCC2)cc1C(F)(F)F",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.Nc1ccc2c(c1)S(=O)(=O)C=C2.O=C(O)c1ccccn1>>O=C(Nc1ccc2c(c1)S(=O)(=O)C=C2)c1ccccn1",
        "output": "548"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.CCOC(=O)C1(CCN2CCCC2)CCNCC1.Clc1ccc(CNc2nc(Cl)nc3ccsc23)c(Cl)c1.O=C([O-])O.[Na+]>>CCOC(=O)C1(CCN2CCCC2)CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3sccc3n2)CC1",
        "output": "36"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cc1cc([N+](=O)[O-])cnc1C#N.[Ca+2].[Cl-].[Cl-].[Fe]>>Cc1cc(N)cnc1C#N",
        "output": "269"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1c(N(CC)CC)nc2ccc(Cl)cc2c1Cc1ccccc1Cl.[Na+].[OH-]>>CCN(CC)c1nc2ccc(Cl)cc2c(Cc2ccccc2Cl)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.Cc1cc([N+](=O)[O-])cnc1Cl.NCc1ccccn1.O>>Cc1cc([N+](=O)[O-])cnc1NCc1ccccn1",
        "output": "70"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(CO[Si](C)(C)C(C)(C)C)Cc2nnc(C3(c4ccc(-c5cccc(C#N)n5)cc4)CC3)n2CCS1.CO.Cl>>CC1(CO)Cc2nnc(C3(c4ccc(-c5cccc(C#N)n5)cc4)CC3)n2CCS1",
        "output": "708"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOCC.Nc1ccccc1F.O=[N+]([O-])c1ccccc1CBr.[Li]CCCC>>O=[N+]([O-])c1ccccc1CNc1ccccc1F",
        "output": "272"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCBr.CS(C)=O.Cl.O=C(O)COc1ccccc1O.[Na+].[OH-]>>CCCCOc1ccccc1OCC(=O)O",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC1C(=O)NN=C2COc3cc(Br)c(C4CCN(C(=O)OC(C)(C)C)CC4)cc3N21.O.O=C([O-])[O-].OB(O)c1ccccc1.[K+].[K+]>>CC1C(=O)NN=C2COc3cc(-c4ccccc4)c(C4CCN(C(=O)OC(C)(C)C)CC4)cc3N21",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1Nc1cc(Nc2cc(-c3ccccc3)no2)c(C#N)cc1F.O=C(O)C(F)(F)F>>N#Cc1cc(F)c(N[C@@H]2CCCC[C@@H]2N)cc1Nc1cc(-c2ccccc2)no1",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.Cl.ClCCl.O=C=Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1.c1ccc(N2CCNCC2)c(OCc2ccncc2)c1>>O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(c2ccccc2OCc2ccncc2)CC1",
        "output": "323"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1=COCCC1.C1CCOC1.CS(=O)(=O)O.ClCCl.Oc1ccc2[nH]ncc2c1>>Oc1ccc2c(cnn2C2CCCCO2)c1",
        "output": "878"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=C/C=C\\[C@H](C)[C@H](OCc1ccc(OC)cc1)[C@@H](C)[C@H](O)[C@@H](C)C(=O)N1C(=O)OC[C@H]1Cc1ccccc1.CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.CCOCC.Cc1cccc(C)n1.ClCCl>>C=C/C=C\\[C@H](C)[C@H](OCc1ccc(OC)cc1)[C@@H](C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](C)C(=O)N1C(=O)OC[C@H]1Cc1ccccc1",
        "output": "839"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)c1cccc2nc(-c3ccc(C)cc3)oc12.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COC(=O)c1cccc2nc(-c3ccc(CBr)cc3)oc12",
        "output": "29"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(Sc2ccc(Sc3nncn3C)nc2C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(Sc2ccc(Sc3nncn3C)nc2C(=O)O)cc1",
        "output": "569"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(CNC(=O)OC(C)(C)C)CNc1nc(-c2ccc(Cl)c(Cl)c2)c2c(N)c(C(N)=O)sc2n1.Cl.ClCCl>>CC(C)(CN)CNc1nc(-c2ccc(Cl)c(Cl)c2)c2c(N)c(C(N)=O)sc2n1",
        "output": "538"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCI.O.O=C(CCC(=O)N1CCC(c2ccc(Cl)cc2)CC1)c1ccc2c(c1)CCNCC2.O=C([O-])[O-].[K+].[K+]>>CCN1CCc2ccc(C(=O)CCC(=O)N3CCC(c4ccc(Cl)cc4)CC3)cc2CC1",
        "output": "184"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(NC(=O)Nc2ccc3nc(N[C@@H]4CCc5ccccc54)ccc3c2)CC1.ClCCl.O.O=C(O)C(F)(F)F.O=C([O-])[O-].[Na+].[Na+]>>O=C(Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1)NC1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(O)c1cccc2c1CCCC2.O=S(Cl)Cl>>O=C(Cl)c1cccc2c1CCCC2",
        "output": "3"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1c(C(=O)O)nc2sccn12.Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CN)c1>>Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2nc3sccn3c2C)c1",
        "output": "697"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CNC.CSc1nc(Cl)cc(Cl)n1.O>>CSc1nc(Cl)cc(N(C)C)n1",
        "output": "162"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)P(C(C)(C)C)C(C)(C)C.Cc1ccccc1.Cc1ccccc1Br.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].c1ccc(Nc2ccccc2)cc1>>Cc1ccccc1N(c1ccccc1)c1ccccc1",
        "output": "894"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COc1ccc2c(c1)NC(=O)CCC2.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1ccc2c(c1)NCCCC2",
        "output": "112"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOc1ccc(B(O)O)cc1.Clc1nc(Nc2cc[nH]n2)cc2ccccc12>>CCOc1ccc(-c2nc(Nc3cc[nH]n3)cc3ccccc23)cc1",
        "output": "865"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.C[Si](C)(C)C#Cc1cccc(NS(=O)(=O)C(F)(F)F)c1.[F-]>>C#Cc1cccc(NS(=O)(=O)C(F)(F)F)c1",
        "output": "337"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.COC(=O)C1CNCCC1=O.Cl.ClCCl>>COC(=O)C1CN(C(=O)OC(C)(C)C)CCC1=O",
        "output": "694"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOP(=O)(CCOCCOCCOCCN)OCC.O=[N+]([O-])c1c(Cl)nc2ccccc2c1Cl>>CCOP(=O)(CCOCCOCCOCCNc1c([N+](=O)[O-])c(Cl)nc2ccccc12)OCC",
        "output": "78"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)/C=C/c1c(C2CC2)nn(C)c1Oc1cc(OCc2ccccc2)c(Br)cc1C.O=C(O)C(F)(F)F>>CCOC(=O)/C=C/c1c(C2CC2)nn(C)c1Oc1cc(O)c(Br)cc1C",
        "output": "23"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CCOC(C)=O.O=C(c1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1)c1c(Cl)cccc1[N+](=O)[O-].[Fe]>>Nc1cccc(Cl)c1C(=O)c1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNC1.CN(Cc1ccccn1)Cc1cc(O)cc(-c2cc(Cl)ccn2)n1.Clc1ccccc1.[Cl-].[Cl-].[Zn+2]>>CN(Cc1ccccn1)Cc1cc(O)cc(-c2cc(N3CCCC3)ccn2)n1",
        "output": "398"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.NC1(c2cccc(Br)c2)CC1.O=C(O)c1cncc2c1cnn2-c1ccc(F)cc1>>O=C(NC1(c2cccc(Br)c2)CC1)c1cncc2c1cnn2-c1ccc(F)cc1",
        "output": "790"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(F)ccc1-2.Cl.O.O.[BH4-].[Li+]>>CN1Cc2c(CO)ncn2-c2ccc(F)cc2C1=O",
        "output": "286"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1ccc2nc(-c3c(Cl)cccc3C(F)(F)F)[nH]c2c1.Cl.[Na+].[OH-]>>O=C(O)c1ccc2nc(-c3c(Cl)cccc3C(F)(F)F)[nH]c2c1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CI.CN(C)C=O.Cc1cccc(C(=O)c2ccc(Cl)cc2)c1O.[H-].[Na+]>>COc1c(C)cccc1C(=O)c1ccc(Cl)cc1",
        "output": "62"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "N#Cc1ccc(C(=O)CCC(=O)O)cc1[N+](=O)[O-].[NH4+].[OH-]>>N#Cc1ccc(C(=O)CCC(=O)O)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.N#Cc1cc(Cl)ccn1.O=C([O-])[O-].OB(O)c1ccc(C(F)(F)F)cc1.[Cs+].[Cs+].[Pd+2]>>N#Cc1cc(-c2ccc(C(F)(F)F)cc2)ccn1",
        "output": "947"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCCBr.CN(C)C=O.Ic1nc(I)c(I)[nH]1.O.[H-].[Na+]>>CC(C)(C)OC(=O)NCCn1c(I)nc(I)c1I",
        "output": "276"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CNOC.Cc1cccc(C)c1C(=O)NCCC(C)N1CCC(N(Cc2cccc(Cl)c2)c2ccc(C(=O)O)cc2)CC1.Cl>>CON(C)C(=O)c1ccc(N(Cc2cccc(Cl)c2)C2CCN(C(C)CCNC(=O)c3c(C)cccc3C)CC2)cc1",
        "output": "828"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)OC(=O)N1CCC(C(O)CNC(=O)c2ccc3c(c2)C(C)(C)CCC3(C)C)CC1.ClCCl.O=C([O-])O.O=S(=O)([O-])[O-].[Na+].[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCC(C(=O)CNC(=O)c2ccc3c(c2)C(C)(C)CCC3(C)C)CC1",
        "output": "87"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)[C@H](Cc1ccc(NC(=O)c2c(Cl)cccc2Cl)cc1)NC(=O)c1ccc(S(=O)(=O)NCc2cccc(O)c2)cc1Cl.[Li+].[OH-]>>O=C(N[C@@H](Cc1ccc(NC(=O)c2c(Cl)cccc2Cl)cc1)C(=O)O)c1ccc(S(=O)(=O)NCc2cccc(O)c2)cc1Cl",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.CN(CCN)C(=O)OC(C)(C)C.O=S(=O)(Cl)c1ccc(Br)cc1>>CN(CCNS(=O)(=O)c1ccc(Br)cc1)C(=O)OC(C)(C)C",
        "output": "43"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CCO.COc1cc([N+](=O)[O-])ccc1-n1cnc(Cl)c1.O.[Fe].[Na+].[OH-]>>COc1cc(N)ccc1-n1cnc(Cl)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1nccs1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.COCCCN1C(=O)COc2ccc(COC3CN(C(=O)OCc4ccccc4)CCC3c3ccc(OC4CNC4)cc3)cc21.Cc1ccccc1.O.O.O=C([O-])C(F)(F)F.O=C([O-])C(F)(F)F.O=P([O-])([O-])[O-].[Cl-].[K+].[K+].[K+].[Na+].[Pd+2]>>COCCCN1C(=O)COc2ccc(COC3CN(C(=O)OCc4ccccc4)CCC3c3ccc(OC4CN(c5nccs5)C4)cc3)cc21",
        "output": "657"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCCCC(=O)O.CNOC.Cl.O>>CON(C)C(=O)CCCNC(=O)OC(C)(C)C",
        "output": "54"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)C(O)(c1ccc2cc(C#N)ccc2c1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.CO.ClC(Cl)Cl.O=C([O-])O.[Cl-].[Na+].c1cc[nH+]cc1>>CC(C)C(O)(c1ccc2cc(C#N)ccc2c1)c1c[nH]cn1",
        "output": "838"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)(CO)CCCCCCC(O)CCCCCCC(C)(C)CO.[Na+].[O-]Cl>>CC(C)(CO)CCCCCCC(=O)CCCCCCC(C)(C)CO",
        "output": "87"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CCNCC1.O=C(O)c1ccc2cc(O)ccc2c1>>CC1CCN(C(=O)c2ccc3cc(O)ccc3c2)CC1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CC(C)O.CCN(CC)CC.O=C(NCC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1)Oc1ccccc1>>CC(C)(C)OC(=O)N1CCC(NC(=O)NCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1",
        "output": "488"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCOCC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[Si](C)(C)CCOC(=O)NCCCCCC(=O)O.F[P-](F)(F)(F)(F)F.Nc1cc(I)cc(I)c1>>C[Si](C)(C)CCOC(=O)NCCCCCC(=O)Nc1cc(I)cc(I)c1",
        "output": "365"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)Br.CN(C)C=O.COc1cccc(C=O)c1O.O.O=C([O-])[O-].[Cl-].[K+].[K+].[NH4+]>>COc1cccc(C=O)c1OC(C)C",
        "output": "153"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COc1cccc(N)c1[N+](=O)[O-]>>COc1cccc(N)c1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(N)CO.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ncc(C(=O)NCCN2CCCC2(C)C)cc1NC(=O)c1cnn2cc(-c3ccc(C(=O)O)c(F)c3)ccc12.ClCCl.F[P-](F)(F)(F)(F)F>>Cc1ncc(C(=O)NCCN2CCCC2(C)C)cc1NC(=O)c1cnn2cc(-c3ccc(C(=O)NC(C)(C)CO)c(F)c3)ccc12",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CCn1c(Cn2c(=O)n(C(C)C)c3ccccc32)nc2cc(C#N)ccc21.Cl.[NH4+].[Na+].[OH-].[OH-]>>CC(C)CCn1c(Cn2c(=O)n(C(C)C)c3ccccc32)nc2cc(C(=O)O)ccc21",
        "output": "445"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(C(C)C)C(C)C.CN(C)c1ccncc1.Cl.ClCCl.NCc1ccccc1Br>>CC(C)(C)OC(=O)NCc1ccccc1Br",
        "output": "686"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.N#Cc1ccc(N)c(Cl)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>NCc1ccc(N)c(Cl)c1",
        "output": "175"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.N[C@@H](Cc1cc(F)cc(F)c1)c1ncccc1-c1cnc2[nH]ccc2c1.O=C(O)Cn1nc(C(F)(F)F)c2c1C1CC1CC2>>O=C(Cn1nc(C(F)(F)F)c2c1C1CC1CC2)N[C@@H](Cc1cc(F)cc(F)c1)c1ncccc1-c1cnc2[nH]ccc2c1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[C@H]1CCCNC1.F[P-](F)(F)(F)(F)F.O=C(O)CN1CCN(c2cccc3c2cnn3-c2ccccc2F)C1=O>>O=C(CN1CCN(c2cccc3c2cnn3-c2ccccc2F)C1=O)N1CCC[C@H](F)C1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.CCCCCC.CCOC(=O)C(C)(C)NC(=O)c1c(Cl)c2cc(Oc3ccc(C(F)(F)F)cc3)ccc2n1-c1ccc(OC(C)C)cc1.Cl>>CC(C)Oc1ccc(-n2c(C(=O)NC(C)(C)C(=O)O)c(Cl)c3cc(Oc4ccc(C(F)(F)F)cc4)ccc32)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrBr.CC(=O)O.COc1ccc(F)cc1-c1c(Cl)cccc1Cl.[Fe]>>COc1c(Br)cc(F)cc1-c1c(Cl)cccc1Cl",
        "output": "98"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.Cl.N#CCN.O=C(O)CCCBr.On1nnc2ccccc21>>N#CCNC(=O)CCCBr",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)C(=O)CN1C(=O)N(CC(=O)O)C(=O)N(C2CCCCC2)c2ccccc21.Cc1nc(-c2cccc(N)c2)cs1.ClCCl>>Cc1nc(-c2cccc(NC(=O)CN3C(=O)N(CC(=O)C(C)(C)C)c4ccccc4N(C4CCCCC4)C3=O)c2)cs1",
        "output": "365"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC(C(=O)OC)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc(C)cc1.CO.O.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.COc1ccc2oc(-c3ccc(F)cc3)nc2c1.ClCCl>>Oc1ccc2oc(-c3ccc(F)cc3)nc2c1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1cc(-c2ccc(OC)cc2)n[nH]c1=O.O=[N+]([O-])c1ccc(CCl)cc1>>COC(=O)c1cc(-c2ccc(OC)cc2)nn(Cc2ccc([N+](=O)[O-])cc2)c1=O",
        "output": "842"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1CCC(C)N1.CCO.COc1ccc([N+](=O)[O-])c(Cl)n1>>COc1ccc([N+](=O)[O-])c(N2C(C)CCC2C)n1",
        "output": "220"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)CSc1ccc(F)cc1Br.Cl.[Na+].[OH-]>>O=C(O)CSc1ccc(F)cc1Br",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc(Cl)c(C)cc1N.FC(F)(F)c1cc(Cl)nc(-c2cccnc2)n1>>COc1cc(Cl)c(C)cc1Nc1cc(C(F)(F)F)nc(-c2cccnc2)n1",
        "output": "161"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(Br)cc1.Cc1ccc(O)cc1.[Cu].[K+].[OH-]>>Cc1ccc(Oc2ccc(C)cc2)cc1",
        "output": "238"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(CCl)cc1>>O=C(Cl)c1ccc(CCl)cc1",
        "output": "448"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(Br)c(CCC(=O)OC(C)(C)C)c(Br)c1.O=C(O)C(F)(F)F>>COc1cc(Br)c(CCC(=O)O)c(Br)c1",
        "output": "278"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.Clc1ccc2c(c1)CCC1(CCNCC1)O2.Fc1ccc2c(c1)COC21CCN(Cc2ccccc2)CC1.O=C(Cl)OCCCl>>Fc1ccc2c(c1)COC21CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)C(O)CN.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl.O=C(O)CCNC(=O)OCc1ccccc1.Oc1cccc2[nH]nnc12>>CC(C)C(O)CNC(=O)CCNC(=O)OCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNC1.CN(C)C=O.ClCCl.Fc1cccc(Br)c1.O.O=C([O-])[O-].[K+].[K+]>>Brc1cccc(N2CCCC2)c1",
        "output": "26"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(CC)Cn1c(=O)c(-c2ccccc2)cc2c(O)c(C(=O)OC)nc(-c3ccncc3)c21.C[O-].NCCC(=O)O.O=C([O-])O.[Na+].[Na+]>>CCC(CC)Cn1c(=O)c(-c2ccccc2)cc2c(O)c(C(=O)NCCC(=O)O)nc(-c3ccncc3)c21",
        "output": "487"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCBr.CCC(=O)c1ccc(O)cc1.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>C=CCOc1ccc(C(=O)CC)cc1",
        "output": "77"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1c(OC(C)C)cc(Br)c2ccncc12.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cc1c(OC(C)C)cc(Br)c2cc[n+]([O-])cc12",
        "output": "262"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCOc1ccc(-c2cc(CCl)on2)cc1.c1ccc(-c2nc3cn[nH]cc-3n2)cc1>>CCCOc1ccc(-c2cc(Cn3cc4nc(-c5ccccc5)nc-4cn3)on2)cc1",
        "output": "997"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.N#CCCc1ccc([N+](=O)[O-])cc1.[Pd]>>N#CCCc1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrBr.CC(C)n1c(=O)cc(C(F)(F)F)[nH]c1=O.ClC(Cl)Cl.O=S([O-])O.[Na+].[Na+].[OH-]>>CC(C)n1c(=O)[nH]c(C(F)(F)F)c(Br)c1=O",
        "output": "381"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COc1ccc(C2CC(=O)c3cc(OC)c(OC)c(OC)c32)cc1[N+](=O)[O-].[Pd]>>COc1ccc(C2CC(=O)c3cc(OC)c(OC)c(OC)c32)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1Cc2ccc(Cl)nc2OC(C2CC2)C1.COc1cc(N)ccc1-n1cnc(C)n1>>COc1cc(Nc2ccc3c(n2)OC(C2CC2)CN(C)C3)ccc1-n1cnc(C)n1",
        "output": "434"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCc1cnc(Cl)nc1.CN(C)C=O.O.O=C([O-])[O-].OC1CCNCC1.[K+].[K+]>>CCCc1cnc(N2CCC(O)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CNC(=O)[C@@H](N)C(C)(C)C.O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1>>CNC(=O)[C@@H](NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C",
        "output": "738"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCNCC.CN(C)C=O.ClCCl.O.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(I)c(O)c1>>CCN(CC)C(=O)c1ccc(I)c(O)c1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CN1CCOCC1.Cc1cc(C(=O)N2CCCCc3ccccc32)ccc1CNC(=O)N1CCC(=O)N(CC(=O)O)c2cccc(F)c21.O.[BH4-].[Cl-].[NH4+].[Na+]>>Cc1cc(C(=O)N2CCCCc3ccccc32)ccc1CNC(=O)N1CCC(=O)N(CCO)c2cccc(F)c21",
        "output": "231"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)CC[C@@H]1CC(F)(F)CN1C(=O)OC(C)(C)C.O.O.[Li]O>>CC(C)(C)OC(=O)N1CC(F)(F)C[C@H]1CCC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COc1ccc2c(c1OC)C1(CC=CC1)N1CCc3cc4c(cc3C1C2)OCO4.[BH4-].[Na+]>>COc1ccc2c(c1OC)C1(CCCC1)N1CCc3cc4c(cc3C1C2)OCO4",
        "output": "143"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)c1ccc(CNCCc2c(Cl)cccc2Cl)cc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O.O=C(O)c1cccc2cc[nH]c12>>CC(C)(C)c1ccc(CN(CCc2c(Cl)cccc2Cl)C(=O)c2cccc3cc[nH]c23)cc1",
        "output": "893"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(C(C)C)C(C)C.CN(C)C=O.O=Cc1cc(Cl)ccc1O>>CC(C)(C)[Si](C)(C)Oc1ccc(Cl)cc1C=O",
        "output": "746"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NCCc1cccc(C(F)(F)F)c1.O=C(O)c1ccc(-c2ccncc2)s1>>O=C(NCCc1cccc(C(F)(F)F)c1)c1ccc(-c2ccncc2)s1",
        "output": "736"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.COC(=O)CCC(=O)c1cccc(O)c1O.O>>COC(=O)CCC(=O)c1cccc(OC(C)=O)c1O",
        "output": "46"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)C1CC(N=[N+]=[N-])CN1C(=O)OC(C)(C)C.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)C1CC(N)CN1C(=O)OC(C)(C)C",
        "output": "89"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CNC[C@H](C)O.Cc1nc2c3c(c(C(=O)O)cc2n1C)CCC1(Cc2ccccc2C1)N3.F[B-](F)(F)F>>Cc1nc2c3c(c(C(=O)N(C)C[C@H](C)O)cc2n1C)CCC1(Cc2ccccc2C1)N3",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(CC)OC(C[N+](=O)[O-])c1cnc(C)nc1.Cc1ncc(C(CN)OC2CCCC2)cn1.O=[Pt]=O.[Pd]>>CCC(CC)OC(CN)c1cnc(C)nc1",
        "output": "226"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COc1cc(OC)c2c(c1)O/C(=C\\c1ccccc1)C2=O.ClCCl.O>>COc1cc(O)c2c(c1)O/C(=C\\c1ccccc1)C2=O",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(Br)cc1-2.O.[Li+].[OH-]>>NC(=O)c1nc2n(c1C(=O)O)CCOc1cc(F)c(Br)cc1-2",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#C[Si](C)(C)C.CCCCN(CCCC)c1ccc(I)cc1.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.c1ccccc1>>CCCCN(CCCC)c1ccc(C#C[Si](C)(C)C)cc1",
        "output": "826"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CC1CN=C(c2cc3cccc(N(C)S(=O)(=O)c4ccccn4)c3[nH]2)S1.CCOC(C)=O.CO.Cl.O.[K+].[OH-]>>CN(c1cccc2cc(C3=NCC(CC(=O)O)S3)[nH]c12)S(=O)(=O)c1ccccn1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CCCc1c(OCCCBr)ccc(C(C)=O)c1O.CI.O=C([O-])[O-].[K+].[K+]>>CCCc1c(OCCCBr)ccc(C(C)=O)c1OC",
        "output": "62"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COc1ccc(CCl)cc1.O.O=C([O-])[O-].O=[N+]([O-])c1cccc(-c2n[nH]cc2I)c1.[Cs+].[Cs+]>>COc1ccc(Cn2cc(I)c(-c3cccc([N+](=O)[O-])c3)n2)cc1",
        "output": "842"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CCc1cc2c(=O)n(CC(=O)C34CC5CC(CC(C5)C3)C4)c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3)c2s1.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCc1cc2c(=O)n(CC(=O)C34CC5CC(CC(C5)C3)C4)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c2s1",
        "output": "979"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCN1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.O=C1CCC2(CC1)C(=O)Nc1cc(Br)ccc12.[Na+]>>O=C1Nc2cc(Br)ccc2C12CCC(N1CCOCC1)CC2",
        "output": "187"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(Cl)ncc1Br.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>Cc1cc(Cl)[n+]([O-])cc1Br",
        "output": "262"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.ClCCl.NC(=O)c1cc(-c2ccccc2)cc2c(C3CCNCC3)c[nH]c12.O=S(=O)(Cl)CCCCl>>NC(=O)c1cc(-c2ccccc2)cc2c(C3CCN(S(=O)(=O)CCCCl)CC3)c[nH]c12",
        "output": "584"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1ccncc1.CCO.Cl.N#Cc1ccc(B(O)O)cc1.O.O=C([O-])[O-].[Na+].[Na+].[Pd]>>N#Cc1ccc(-c2ccncc2)cc1",
        "output": "872"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCOC(=O)c1ccc(N2CCC3(CC2)OCCO3)cc1>>CCOC(=O)c1ccc(N2CCC(=O)CC2)cc1",
        "output": "251"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1nc(N)sc1C(=O)NCc1ccccc1.N#Cc1ccc(C(=O)Cl)cc1>>Cc1nc(NC(=O)c2ccc(C#N)cc2)sc1C(=O)NCc1ccccc1",
        "output": "673"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1c(Nc2ccccc2F)cncc1-c1ccccc1Cl.Cc1ccc(S(=O)(=O)O)cc1.O.O=C1CCC(=O)N1I>>COC(=O)c1c(Nc2ccc(I)cc2F)cncc1-c1ccccc1Cl",
        "output": "834"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)c1ccc(N)cc1.CN(C)c1ccc(C=O)cc1>>CC(C)c1ccc(NCc2ccc(N(C)C)cc2)cc1",
        "output": "359"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.ClCCl.OCCn1c2ccccc2c2ccccc21>>CC(=O)OCCn1c2ccccc2c2ccccc21",
        "output": "254"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Cl.ClCCl.N[C@H]1CCc2cc(Br)ccc2C1>>CC(C)(C)OC(=O)N[C@H]1CCc2cc(Br)ccc2C1",
        "output": "631"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC1=NC(C)(c2cc(N)ccc2F)COC1(CF)CF.CCOC(C)=O.CN(C)C=O.CN1CCOCC1.Cc1cc(C#N)cnc1C(=O)O.ClCCCl.O.On1nnc2cccnc21>>Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c(C2(C)COC(CF)(CF)C(NC(=O)OC(C)(C)C)=N2)c1",
        "output": "985"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1C(=O)OCCc2cc(N)ccc21.Fc1cccc(OC2CCOC2)c1Nc1nc(Cl)ncc1Cl>>CN1C(=O)OCCc2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4OC4CCOC4)n3)ccc21",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)c1nc(Cl)ncc1F.CCN(C(C)C)C(C)C.Cl.O.O=C(NC1=N[C@@]2(c3ccccc3)CNC[C@H]2CS1)c1ccccc1.O=C([O-])O.[Na+]>>CC(C)c1nc(N2C[C@H]3CSC(NC(=O)c4ccccc4)=N[C@@]3(c3ccccc3)C2)ncc1F",
        "output": "36"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCN(C2COC2)C(CO[Si](C)(C)C(C)(C)C)C1.ClCCl.O=C(O)C(F)(F)F>>CC(C)(C)[Si](C)(C)OCC1CNCCN1C1COC1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=O.COc1c(C(C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(C)c1C1CNC1.Cl.Cl>>COc1c(C(C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(C)c1C1CN(C)C1",
        "output": "217"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCc1ccc(CNc2ccc(C(C)C)cc2)cn1.COc1ccc2c(c1)C(C(=O)O)CCC2>>CCc1ccc(CN(C(=O)C2CCCc3ccc(OC)cc32)c2ccc(C(C)C)cc2)cn1",
        "output": "315"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCBr.CCOC(C)=O.CN(C)C=O.COC(=O)/C=C/c1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1O.O.O=C([O-])[O-].[K+].[K+]>>C#CCOc1cc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)ccc1/C=C/C(=O)OC",
        "output": "154"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C(=O)O)C(F)(F)F.CN(C)C=O.ClCCCl.ClCCl.O=C(NCc1cc(OC(F)(F)F)ccc1F)c1cn(CCCCc2cc3cc(C4CNC4)[nH]c3nn2)nn1.On1nnc2ccccc21.[Na+].[OH-]>>CC(C)(C(=O)N1CC(c2cc3cc(CCCCn4cc(C(=O)NCc5cc(OC(F)(F)F)ccc5F)nn4)nnc3[nH]2)C1)C(F)(F)F",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(CCl)C(=O)C(=Cc1ccc(Cl)cc1)n1cncn1.CC(C)O.[BH4-].[Na+]>>CC(C)(CCl)C(O)C(=Cc1ccc(Cl)cc1)n1cncn1",
        "output": "288"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrBr.CC(=O)C(C)(C)C(Cl)C=C(C)C.Cl.ClC(Cl)Cl>>CC(C)=CC(Cl)C(C)(C)C(=O)CBr",
        "output": "173"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCOc1ccc(C(C)=O)cc1C(F)(F)F.OCCCCC#Cc1ccc(C(F)(F)F)cc1>>OCCCCCCc1ccc(C(F)(F)F)cc1",
        "output": "717"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#CCCN(C(=O)OC(C)(C)C)S(=O)(=O)Cc1ccc(Cl)c(Cl)c1.CCN(CC)CC.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Clc1ccc(NC(c2ccccc2)c2ccccc2)c(I)c1.[Cu]I>>CC(C)(C)OC(=O)N(CCC#Cc1cc(Cl)ccc1NC(c1ccccc1)c1ccccc1)S(=O)(=O)Cc1ccc(Cl)c(Cl)c1",
        "output": "664"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cc2c(CC(=O)O)cccc2cn1.NCc1ccc(C(F)(F)F)cc1.NCc1ccc(OC(F)(F)F)cc1>>Cc1cc2c(CC(=O)NCc3ccc(C(F)(F)F)cc3)cccc2cn1",
        "output": "599"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].ClCCl.Nc1ccc(-c2ccc(F)cc2)cn1.[Na+]>>Nc1ncc(-c2ccc(F)cc2)cc1Br",
        "output": "292"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1c(Cl)cccc1C(=O)O.Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CN)c1>>Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2cccc(Cl)c2C)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COc1ccc(CCCO)cc1OC.CS(=O)(=O)Cl.ClCCl>>COc1ccc(CCCOS(C)(=O)=O)cc1OC",
        "output": "0"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)c1ccc(-c2nc(CO[Si](C)(C)C(C)(C)C)cs2)cc1.CCN(CC)CC.F.F.F>>CC(C)(C)OC(=O)c1ccc(-c2nc(CO)cs2)cc1",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C1(C)CCN(C2=NOC3(C2)CN(C(=O)OC(C)(C)C)C3)CC1.O=Cc1cc(C2CC2)c(-c2ccc(F)cc2)cc1OC1COC1>>CCOC(=O)C1(C)CCN(C2=NOC3(C2)CN(Cc2cc(C4CC4)c(-c4ccc(F)cc4)cc2OC2COC2)C3)CC1",
        "output": "935"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1cn(Cc2ccc(OC)cc2)c(=O)c(Cl)c1C(=O)OC.Cl.O.[Li+].[OH-]>>COC(=O)c1c(C(=O)O)cn(Cc2ccc(OC)cc2)c(=O)c1Cl",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCC2=NCCCN2CC1.C1CCOC1.CCOC(=O)Nc1nc2cc(Cl)c(Cl)cc2nc1OC.COc1cccc(N2CCNCC2)c1>>COc1cccc(N2CCN(C(=O)Nc3nc4cc(Cl)c(Cl)cc4nc3OC)CC2)c1",
        "output": "613"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC1(C)Cc2c(c(C(=O)O)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1.CCN(C(C)C)C(C)C.Nc1cc(C(F)F)ccc1F.O=S(Cl)Cl>>CC1(C)Cc2c(c(C(=O)Nc3cc(C(F)F)ccc3F)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1",
        "output": "50"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cccc(-c2cc(NCCCN)nc(N)n2)c1C.O=S(=O)(Cl)c1ccc(Cl)cc1>>Cc1cccc(-c2cc(NCCCNS(=O)(=O)c3ccc(Cl)cc3)nc(N)n2)c1C",
        "output": "43"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.CCOC(=O)CBr.COc1ccc(Cl)cc1NC(=O)Cn1nc(C(F)(F)F)c2c1CNCC2.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CN1CCc2c(C(F)(F)F)nn(CC(=O)Nc3cc(Cl)ccc3OC)c2C1",
        "output": "467"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCCCNCCO.COc1ccc([N+](=O)[O-])c(Cl)n1.O>>CCCCN(CCO)c1nc(OC)ccc1[N+](=O)[O-]",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC[C@@H](N)C(=O)N1CC(F)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cn1nc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)c2ccc(F)cc21.F[P-](F)(F)(F)(F)F.O=C(O)C(F)(F)F>>CCC[C@@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)C(=O)N1CC(F)C1",
        "output": "989"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(C)(C)OC(=O)N1CC(c2ccc(C=O)cc2)C1.CCCCCC.CCO.CCOC(C)=O.Cl.NO.O.[Na+]>>CC(C)(C)OC(=O)N1CC(c2ccc(C=NO)cc2)C1",
        "output": "30"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.O.O=C(O)[C@](O)(c1cccs1)C1CCCC1.O=C(n1ccnc1)n1ccnc1.O[C@@H]1CN2CCC1CC2>>O=C(O[C@@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CC(C)c1nc(N)nc(Cl)n1.CC(N)CCc1ccc(F)cc1.O=C([O-])[O-].[K+].[K+]>>CC(CCc1ccc(F)cc1)Nc1nc(N)nc(C(C)C)n1",
        "output": "578"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)c1ccncc1.CC(C)=O.CO.O=C([O-])C(O)C(O)C(=O)[O-].[BH4-].[Na+]>>CC(O)c1ccncc1",
        "output": "24"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CNOC.Cc1cc(C(=O)O)cc(Cl)n1.Cl.ClCCl.O.O.On1nnc2ccccc21>>CON(C)C(=O)c1cc(C)nc(Cl)c1",
        "output": "828"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCNc1nc(N)nc(C)c1Cc1cccc(CCl)c1.CN(C)C=O.CS(C)=O.O=C([O-])O.[C-]#N.[K+].[Na+]>>CCCCCNc1nc(N)nc(C)c1Cc1cccc(CC#N)c1",
        "output": "38"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1c(-c2ccccc2)c2cc([N+](=O)[O-])ccc2n1C.[K+].[OH-]>>Cn1c(C(=O)O)c(-c2ccccc2)c2cc([N+](=O)[O-])ccc21",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCNCC1.C1CCOC1.O=[N+]([O-])c1ccc(CCl)cc1.[Cl-].[NH4+]>>O=[N+]([O-])c1ccc(CN2CCCCC2)cc1",
        "output": "156"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.C[O-].Nc1nc(Cl)c2c(n1)OCC2.[Na+]>>COc1nc(N)nc2c1CCO2",
        "output": "461"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)c1ccc(C(=O)N(C)CC(F)(F)F)nc1.O.O.[Li+].[OH-]>>CN(CC(F)(F)F)C(=O)c1ccc(C(=O)O)cn1",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.N#CC(O)CC1CCCCC1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>NCC(O)CC1CCCCC1",
        "output": "246"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CC[C@H](N)C1.CN(C)C=O.Cc1ccc(F)c([N+](=O)[O-])c1.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(N[C@H]2CC[C@H](NC(=O)OC(C)(C)C)C2)c([N+](=O)[O-])c1",
        "output": "572"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.CN(C)c1ccncc1.CO.F[P-](F)(F)(F)(F)F.NC(=O)c1cncc(N)c1.O=C(O)COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>NC(=O)c1cncc(NC(=O)COc2ccc(C34CC5CC(CC(C5)C3)C4)cc2)c1",
        "output": "724"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCc1nccc2ccc(C(=O)O)cc12.CO.O=S(=O)(O)O>>CCCCc1nccc2ccc(C(=O)OC)cc12",
        "output": "33"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.Cl.O=C(O)c1ncccc1C1CC1>>COC(=O)c1ncccc1C1CC1",
        "output": "331"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCI.CCCc1nc(C)n(-c2ccc(O)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CN(C)C=O.O.O=C([O-])[O-].[Cs+].[Cs+]>>CCCOc1ccc(-n2c(C)nc(CCC)c(Cc3ccc(-c4ccccc4C#N)cc3)c2=O)cc1",
        "output": "198"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)CCN.CN(C)C=O.COc1ccc(C(=O)N2c3ccccc3C(n3c4ccccc4c4ccccc43)CC2CCCCC(=O)O)cc1OC.Cl.Cl.On1nnc2ccccc21>>CCOC(=O)CCNC(=O)CCCCC1CC(n2c3ccccc3c3ccccc32)c2ccccc2N1C(=O)c1ccc(OC)c(OC)c1",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCCCCCCCCCCc1cccc(OC)c1C(=O)Cl.CCN(CC)CC.ClCCl.Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1>>CCCCCCCCCCCCCCCc1cccc(OC)c1C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1",
        "output": "11"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CC=C(c2c[nH]c3ccc(Nc4ncc(Br)c(NCc5ccc(C(F)(F)F)cc5)n4)cc23)CC1.ClCCl.O=C(O)C(F)(F)F>>FC(F)(F)c1ccc(CNc2nc(Nc3ccc4[nH]cc(C5=CCNCC5)c4c3)ncc2Br)cc1",
        "output": "800"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN.Cc1ccc(C(=O)O)cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Cl)c1=O.ClCCl.On1nnc2ccccc21>>CNC(=O)c1ccc(C)c(-n2c(C)cc(OCc3ccc(F)cc3F)c(Cl)c2=O)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1=CCC=CC1.CCO.Cc1[nH]n(C2CCN(Cc3ccccc3)CC2)c(=O)c1Cc1ccccc1.[OH-].[OH-].[Pd+2]>>Cc1[nH]n(C2CCNCC2)c(=O)c1Cc1ccccc1",
        "output": "84"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(CCN)cc1OC.COc1ccc(I)c(OCC2CO2)c1.O.O=S1(=O)CCCC1>>COc1ccc(I)c(OCC(O)CNCCc2ccc(OC)c(OC)c2)c1",
        "output": "16"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCCCCCCCCCCCCCOC1CC(C(=O)O)CC(OCCCCCCCCCCCCCCCCCC)C1OCCCCCCCCCCCCCCCCCC.CCN=C=NCCCN(C)C.Cl.ClC(Cl)Cl.Nc1ccc(CO)cc1.O.On1nnc2ccccc21>>CCCCCCCCCCCCCCCCCCOC1CC(C(=O)Nc2ccc(CO)cc2)CC(OCCCCCCCCCCCCCCCCCC)C1OCCCCCCCCCCCCCCCCCC",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CN1CCNCC1.Nc1cc(Cl)nc(Cl)c1.O>>CN1CCN(c2cc(N)cc(Cl)n2)CC1",
        "output": "220"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)CCCl.Nc1cccc(-c2ccc(O)cc2C2CCC2)n1>>CN(C)CCOc1ccc(-c2cccc(N)n2)c(C2CCC2)c1",
        "output": "74"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccc(Br)cc1.C1CC2(CCN1)COC2.C1CCOC1.CCN(CC)CC>>Brc1ccc(CN2CCC3(CC2)COC3)cc1",
        "output": "248"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CN(C)C=O.CN(C)c1ccncc1.CO.Cc1cccc(C(=O)O)c1N.O=C(Cl)OC(Cl)(Cl)Cl.O=C([O-])O.[Cl-].[NH4+].[Na+]>>COC(=O)c1cccc(C)c1N",
        "output": "195"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CNC1CCN(Cc2ccccc2)CC1.CO.Cl.O=CC1CC1.[BH3-]C#N.[Na+]>>CN(CC1CC1)C1CCN(Cc2ccccc2)CC1",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(O)c1ccccc1O.O=S(=O)(O)Cl>>O=C(O)c1cc(S(=O)(=O)Cl)ccc1O",
        "output": "357"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(N)(=O)=O.Cc1cccc(C2CCN(C(=O)c3cnc4c(C(=O)O)cnn4c3NCc3ccccc3)CC2)c1>>Cc1cccc(C2CCN(C(=O)c3cnc4c(C(=O)NS(C)(=O)=O)cnn4c3NCc3ccccc3)CC2)c1",
        "output": "991"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)cccc2n1.O=C(Cl)C1CCCCC1>>Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C5CCCCC5)c4)CC3)cccc2n1",
        "output": "9"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)C(C(=O)OCC)c1ccc([N+](=O)[O-])c(F)c1.CCOC(=O)C(Cl)(C(=O)OCC)c1ccc([N+](=O)[O-])c(F)c1.CCOC(C)=O.O=C[O-].[NH4+].[Pd]>>CCOC(=O)C(C(=O)OCC)c1ccc(N)c(F)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NS(=O)(=O)c1cc(C(=O)O)cc([N+](=O)[O-])c1Oc1cccc(C(F)(F)F)c1.NS(=O)(=O)c1cc(C(=O)O)cc([N+](=O)[O-])c1Oc1ccccc1>>Nc1cc(C(=O)O)cc(S(N)(=O)=O)c1Oc1cccc(C(F)(F)F)c1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COc1cc([N+](=O)[O-])ccc1-n1cnc(C)c1.[Pd]>>COc1cc(N)ccc1-n1cnc(C)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCCCC(CC(=O)OCC)c1oc2cc(C(F)(F)F)ccc2c1C.Cc1ccccc1.O.[H-]>>CCCCC(CCO)c1oc2cc(C(F)(F)F)ccc2c1C",
        "output": "225"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCCOc1ccccc1.CN(C)C=O.O=C([O-])[O-].OC1CCNCC1.[K+].[K+]>>OC1CCN(CCOc2ccccc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.Cc1cc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)ccc1OCCO>>Cc1cc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)ccc1OCCOS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cn(Cc2ccccc2)nc1OCc1ccc(OCc2nc(-c3ccco3)oc2C)c(OCc2ccccc2)c1.Cl.O.[Na+].[OH-]>>Cc1oc(-c2ccco2)nc1COc1ccc(COc2nn(Cc3ccccc3)cc2C(=O)O)cc1OCc1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)Cc1c(C)n(Cc2ccccc2)c2ccc(OCc3nc4ccccc4s3)cc12.CO.[Na+].[OH-]>>Cc1c(CC(=O)O)c2cc(OCc3nc4ccccc4s3)ccc2n1Cc1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrP(Br)Br.ClCCl.O=[N+]([O-])c1cc(Br)cc(CO)c1>>O=[N+]([O-])c1cc(Br)cc(CBr)c1",
        "output": "300"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#Cc1cnn2c(C(F)(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12.Cc1ccc(Br)cc1S(N)(=O)=O>>Cc1ccc(C#Cc2cnn3c(C(F)(F)F)cc(-c4ccc(C(F)(F)F)cc4)nc23)cc1S(N)(=O)=O",
        "output": "659"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cc2c(Nc3ccc(Oc4ccccc4OC)cc3)c(C#N)cnc2cc1OCc1ccccc1.CSc1ccccc1.O=C(O)C(F)(F)F>>COc1cc2c(Nc3ccc(Oc4ccccc4OC)cc3)c(C#N)cnc2cc1O",
        "output": "23"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN[C@H]1CC[C@@H](Oc2cc(F)ccc2[N+](=O)[O-])CC1.CS(=O)(=O)Cl.Cl>>CN([C@H]1CC[C@@H](Oc2cc(F)ccc2[N+](=O)[O-])CC1)S(C)(=O)=O",
        "output": "584"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N1CCNCC1.CCCCO.CCN(C(C)C)C(C)C.CCOc1ccc(CN(CC2CC2)c2nc(Cl)nc3c2CN(C(C)C)C3=O)cc1>>CCOc1ccc(CN(CC2CC2)c2nc(N3CCN(C(C)=O)CC3)nc3c2CN(C(C)C)C3=O)cc1",
        "output": "36"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)S(=O)(=O)Cl.CCCCn1c(=O)n(Cc2ccccc2F)c(=O)c2[nH]c(Cc3ccc(N)cc3)nc21>>CCCCn1c(=O)n(Cc2ccccc2F)c(=O)c2[nH]c(Cc3ccc(NS(=O)(=O)C(C)C)cc3)nc21",
        "output": "194"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Nc1ccc2c(c1)CC(=O)CC2.O=C1CCC(=O)N1I>>Nc1cc2c(cc1I)CCC(=O)C2",
        "output": "834"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)=CCC(CN)(c1ccccc1)c1ccccc1.CCN(CC)CC.ClCCl.[Cl-].[NH4+]>>CC(C)=CCC(CNC(=O)OC(C)(C)C)(c1ccccc1)c1ccccc1",
        "output": "631"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNCCN1.CCN(CC)CC.CN(C)C=O.FC(F)(F)c1cc(Cl)ncn1.O>>FC(F)(F)c1cc(N2CCNCC2)ncn1",
        "output": "162"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOCC.COCCl.Cc1cc(O)ccc1Br.[H-].[Na+]>>COCOc1ccc(Br)c(C)c1",
        "output": "375"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCS(=O)(=O)Cl.CCN(CC)CC.CN(C)CCN.CN1CCCCC1C1(CNC(=O)c2c(F)ccc(F)c2Cl)CNC1.ClCCl>>CCCS(=O)(=O)N1CC(CNC(=O)c2c(F)ccc(F)c2Cl)(C2CCCCN2C)C1",
        "output": "584"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCn1cc(C(=O)O)c(=O)c2cc(F)c(Cl)cc21.c1cc(C2CNCCN2)cs1.c1ccncc1>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(c4ccsc4)C3)cc21",
        "output": "280"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C(=O)O)N1CCOCC1.CCN(CC)CC.ClCCCl.ClCCl.NNc1ccc(F)cn1.O.O.On1nnc2ccccc21.[Cl-].[Na+]>>CC(C(=O)NNc1ccc(F)cn1)N1CCOCC1",
        "output": "459"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCc1nc2cc(N)ccc2n1CC(=O)OC(C)(C)C.ClCCCl.O.O=Cc1ccccc1.[Na+]>>CCCc1nc2cc(NCc3ccccc3)ccc2n1CC(=O)OC(C)(C)C",
        "output": "359"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.O=C(NC1CCCNC1)N1CC(c2nc3c(cnn3C3CCCCC3)c(=O)[nH]2)C1.O=C(O)C(F)(F)F>>CC(C)N1CCCC(NC(=O)N2CC(c3nc4c(cnn4C4CCCCC4)c(=O)[nH]3)C2)C1",
        "output": "187"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cc1cc(C)c(CN)c(O)n1.Cl.ClCCl.O.O=C(O)c1ccc(Oc2ccccc2Br)c(Cl)c1.On1nnc2ccccc21>>Cc1cc(C)c(CNC(=O)c2ccc(Oc3ccccc3Br)c(Cl)c2)c(O)n1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.O.O=[N+]([O-])c1ccc(Oc2cccc3c2CCC3(O)C(F)(F)F)c(Cl)c1.[Ca+2].[Cl-].[Cl-]>>Nc1ccc(Oc2cccc3c2CCC3(O)C(F)(F)F)c(Cl)c1",
        "output": "335"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)N1CC[C@H](CN)C1.CCO.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCN1CC[C@H](CN)C1",
        "output": "112"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCN(CC)CC.CCc1nccc(O)c1I.O=P(Cl)(Cl)Cl>>CCc1nccc(Cl)c1I",
        "output": "177"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1cccc(Br)n1.Cc1noc(-c2cccc(B3OC(C)(C)C(C)(C)O3)c2)c1NC(=O)OC(C)c1ccccc1Cl>>CCOC(=O)c1cccc(-c2cccc(-c3onc(C)c3NC(=O)OC(C)c3ccccc3Cl)c2)n1",
        "output": "939"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)C(F)(F)C(F)C(F)(F)F.N.O=C(O)CC12CC3CC(CC(C3)C1)C2>>NC(=O)CC12CC3CC(CC(C3)C1)C2",
        "output": "313"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.NC(=O)c1cc([N+](=O)[O-])ccc1Cl.O.O=S(=O)(Cl)c1ccccc1.c1ccncc1>>N#Cc1cc([N+](=O)[O-])ccc1Cl",
        "output": "374"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc3cc(Oc4ccc(C(F)(F)F)cn4)ccc3n2)CC1.COC[C@H]1CN(C(=O)c2ccc3cc(Oc4ccc(C(F)(F)F)cn4)ccc3n2)CCN1C(=O)OC(C)(C)C>>COC[C@H]1CN(C(=O)c2ccc3cc(Oc4ccc(C(F)(F)F)cn4)ccc3n2)CCN1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)Nc1ccc2c(c1)[nH]c1cc(OCCOCCOCCF)ccc12.Cl>>Nc1ccc2c(c1)[nH]c1cc(OCCOCCOCCF)ccc12",
        "output": "782"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COCC(=O)O.Cl.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1>>COCC(=O)N[C@@H]1CC[C@@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(F)(CC)CN1CCC(COc2ccc(-c3ccc(C(=O)OC)cc3F)cc2C#N)CC1.O.O.[Li]O>>CCC(F)(CC)CN1CCC(COc2ccc(-c3ccc(C(=O)O)cc3F)cc2C#N)CC1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.COc1ccc(CC(=O)Cl)cc1.c1ccc(CC2CCCNC2)cc1>>COc1ccc(CC(=O)N2CCCC(Cc3ccccc3)C2)cc1",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)C(=O)Cl.CCN(CC)CC.CCN(CC)c1cccc(CNc2ccc(F)cc2)n1>>CCN(CC)c1cccc(CN(C(=O)C(C)(C)C)c2ccc(F)cc2)n1",
        "output": "160"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)[Si](Cl)(C(C)C)C(C)C.CCN(CC)CC.O.O=C(CN1CCC(O)(c2ccc3c(c2)COCC3)CC1)c1ccc(O)c(F)c1>>CC(C)[Si](Oc1ccc(C(=O)CN2CCC(O)(c3ccc4c(c3)COCC4)CC2)cc1F)(C(C)C)C(C)C",
        "output": "746"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2ccc(C#N)c(F)c2F)cc1F.CCO.NN.O>>CC(C)(C)OC(=O)Nc1ccc(-c2ccc3c(N)n[nH]c3c2F)cc1F",
        "output": "945"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCCOc1ccc2c(COc3cccc4[nH]c(C(=O)O)cc34)coc2c1.C[C@H]1CN(CCC2(O)CCC(N)CC2)CC[C@@H]1O>>CCOCCOc1ccc2c(COc3cccc4[nH]c(C(=O)NC5CCC(O)(CCN6CC[C@H](O)[C@@H](C)C6)CC5)cc34)coc2c1",
        "output": "137"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)N(NC(=O)c1c(C)c(-c2ccccc2)nc2ccccc12)c1ccccc1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COC(=O)N(NC(=O)c1c(CBr)c(-c2ccccc2)nc2ccccc12)c1ccccc1",
        "output": "625"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.CN(C)C=O.Fc1ccc(Br)cn1.O=C=O.O=[N+]([O-])c1cn2c(n1)OC(CO)CC2.[H-].[Na+]>>O=[N+]([O-])c1cn2c(n1)OC(COc1ccc(Br)cn1)CC2",
        "output": "541"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.COC(=O)c1ccc(C(=O)NC2CCN(c3nc(Nc4ccc(OC)c(OC)c4)c4ncsc4n3)C2)cn1.O.[Na+].[OH-]>>COc1ccc(Nc2nc(N3CCC(NC(=O)c4ccc(C(=O)O)nc4)C3)nc3scnc23)cc1OC",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(C)nc(N2CC3CNCC3C2)n1.Cc1ccc(C(=O)O)c(-n2nccn2)n1.F[P-](F)(F)(F)(F)F>>Cc1cc(C)nc(N2CC3CN(C(=O)c4ccc(C)nc4-n4nccn4)CC3C2)n1",
        "output": "256"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(O)CCN.CCN(CC)CC.CN1CCCC1=O.Cc1cc([N+](=O)[O-])ccc1F.O>>Cc1cc([N+](=O)[O-])ccc1NCCC(C)O",
        "output": "572"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C)O.CN1CCN(c2ccc(N)cc2)CC1.ClCCl.O=C(O)C(F)(F)F.O=[N+]([O-])c1cccc(Oc2nc(Cl)nc3ccsc23)c1>>CN1CCN(c2ccc(Nc3nc(Oc4cccc([N+](=O)[O-])c4)c4sccc4n3)cc2)CC1",
        "output": "808"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOCC.COc1cc(OC(F)(F)F)ccc1Br.O.O=C=O.[Li]CCCC>>COc1cc(OC(F)(F)F)ccc1C(=O)O",
        "output": "654"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCc1nc(C)n(-c2ccc(OC(C)C)c(Cl)c2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1nc(C)n(-c2ccc(OC(C)C)c(Cl)c2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(O)CCCCC1N.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CSc1cccc(Oc2ncc(F)cc2C(=O)O)c1.Cl.Cl.On1nnc2ccccc21>>CSc1cccc(Oc2ncc(F)cc2C(=O)NC2CCCCC2(C)O)c1",
        "output": "674"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCCC1=O.Nc1ccc(Cl)nn1.O=C(Cl)Cc1ccccc1>>O=C(Cc1ccccc1)Nc1ccc(Cl)nn1",
        "output": "527"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cc2cccnc2nc1O.O.[Li+].[OH-]>>O=C(O)c1cc2cccnc2nc1O",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)Cc1c(C(=O)OCC)c2cc(O)ccc2n1-c1ccc(C(C)C)cc1.OB(O)c1cccc(C(F)(F)F)c1.c1ccncc1>>CCOC(=O)Cc1c(C(=O)OCC)c2cc(Oc3cccc(C(F)(F)F)c3)ccc2n1-c1ccc(C(C)C)cc1",
        "output": "920"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCN1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cc(-c2cnc(N)c(-c3cn(C(C)C)nn3)c2)ccc1C(=O)O.F[P-](F)(F)(F)(F)F>>COc1cc(-c2cnc(N)c(-c3cn(C(C)C)nn3)c2)ccc1C(=O)N1CCOCC1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=C(C)C(=O)CC/C(C)=C\\CC/C(C)=C\\CO.CC(=O)OC(C)=O.ClCCl.c1ccncc1>>C=C(C)C(=O)CC/C(C)=C\\CC/C(C)=C\\COC(C)=O",
        "output": "155"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1cccc(Br)c1.CC(C)(C)[O-].Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(Nc2cc3ccccc3c3ccccc23)cc1>>Brc1cccc(N(c2ccccc2)c2cc3ccccc3c3ccccc23)c1",
        "output": "894"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCn1c(=O)n(Cc2ccccc2F)c(=O)c2[nH]c(Cc3ccc(N)cc3)nc21.COc1ccc(OC)c(S(=O)(=O)Cl)c1>>CCCCn1c(=O)n(Cc2ccccc2F)c(=O)c2[nH]c(Cc3ccc(NS(=O)(=O)c4cc(OC)ccc4OC)cc3)nc21",
        "output": "68"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.O=C(c1ccc(Br)cc1)c1ccc(Br)cc1.[BH4-].[Na+]>>OC(c1ccc(Br)cc1)c1ccc(Br)cc1",
        "output": "157"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C[Si](C)(C)[N-][Si](C)(C)C.Cc1ccccc1.N#Cc1ccc(Cl)cc1F.OCCN1CCCC1.[K+]>>N#Cc1ccc(Cl)cc1OCCN1CCCC1",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1C(=O)N(CC2CC2)c2ccccc2O[C@@H]1c1ccccc1.ClCCl.O=C(O)C(F)(F)F>>N[C@@H]1C(=O)N(CC2CC2)c2ccccc2O[C@@H]1c1ccccc1",
        "output": "431"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)O.ClCCl.N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)C1CC1>>CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)C1CC1",
        "output": "131"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CC(C)(C)O.CCOCC.CO.O=C(NOCCO)c1ccc(F)c(F)c1Nc1ccc(I)cc1F.[Cu]I>>CC(C)(O)C#Cc1ccc(Nc2c(C(=O)NOCCO)ccc(F)c2F)c(F)c1",
        "output": "664"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COc1ccc(C2=NN(C3CCN(C(=O)[C@@H](N)Cc4cccnc4)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.Cc1[nH]c2c(-c3c(OCC4CC4)ccc4c3OCO4)ncnc2c1C(=O)O.ClCCl.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Na+]>>COc1ccc(C2=NN(C3CCN(C(=O)[C@H](Cc4cccnc4)NC(=O)c4c(C)[nH]c5c(-c6c(OCC7CC7)ccc7c6OCO7)ncnc45)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC",
        "output": "989"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cc(C)n(-c2cccc(-c3ccccc3OC(F)(F)F)c2)n1.CO.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>Cc1cc(C(=O)O)nn1-c1cccc(-c2ccccc2OC(F)(F)F)c1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.Cc1ccc(S(=O)(=O)N[C@@H](Cc2ccccc2)C(=O)O)cc1.Cl.Cl.F[P-](F)(F)(F)(F)F.Nc1nc(N)c(C(=O)/N=C2\\NCC3(CCNCC3)N2)nc1Cl.O>>Cc1ccc(S(=O)(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCC3(CC2)CN/C(=N\\C(=O)c2nc(Cl)c(N)nc2N)N3)cc1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cnc2nc(N3CC(N(C)C(=O)OC(C)(C)C)C3)c3nncn3c2c1.ClCCl.O=C(O)C(F)(F)F>>CNC1CN(c2nc3ncc(OC)cc3n3cnnc23)C1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(C)cc1C(=O)N[C@H]1CCC[C@@H]1Nc1cnc(C(F)(F)F)cn1.Cc1ccc(-n2ccnn2)c(C(=O)O)c1.Cl.N[C@H]1CCC[C@@H]1Nc1cnc(C(F)(F)F)cn1>>Cc1ccc(-n2ccnn2)c(C(=O)N[C@H]2CCC[C@@H]2Nc2cnc(C(F)(F)F)cn2)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CC[C@@H](CO)NC(=O)OC(C)(C)C.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC[C@@H](C=O)NC(=O)OC(C)(C)C",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.NCc1ccc(Cl)nc1.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)NCc1ccc(Cl)nc1",
        "output": "631"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C1CN(C(C)c2ccccc2)CC1c1cccs1.N#Cc1csc2c1CC1CNCC21>>CC(c1ccccc1)N1CC(C(=O)O)C(c2cccs2)C1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.Cc1ccc(CN2CCC(O)CC2)cc1.Cc1ccccc1.O=C(Cl)c1ccccc1>>Cc1ccc(CN2CCC(OC(=O)c3ccccc3)CC2)cc1",
        "output": "51"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "N#CCCCCN1CCC(=C(c2ccccc2)c2ccccc2)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCCCCCN1CCC(=C(c2ccccc2)c2ccccc2)CC1",
        "output": "246"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[C@H](N)C(=O)O.O.[Na+].[OH-]>>C[C@H](NC(=O)OC(C)(C)C)C(=O)O",
        "output": "626"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl.O=P(O)(O)O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1ccc(Cl)c(Nc2ccccc2CO)c1Cl",
        "output": "72"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(Cl)C(C)(C)C.COc1ccccc1Cl.ClCCl.O.OB(O)c1ccccc1.[Cs+].[F-].[Pd+2]>>COc1ccccc1-c1ccccc1",
        "output": "892"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(C)=O.C[C@@H](N)c1cccc(Cl)c1.Cc1cc(C(=O)Nc2cc(C=O)ccc2Cl)no1.ClCCCl.[Na+]>>Cc1cc(C(=O)Nc2cc(CN[C@H](C)c3cccc(Cl)c3)ccc2Cl)no1",
        "output": "683"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@H](N)C(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC2CC2)C1=O.O=C(O)Cc1cc(F)cc(F)c1>>C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC2CC2)C1=O",
        "output": "133"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC1CN(C(=O)OC(C)(C)C)CCN1.ClCCCl.ClCCl.O=Cc1ccc(-c2ccccc2)cc1.[Na+]>>CC1CN(C(=O)OC(C)(C)C)CCN1Cc1ccc(-c2ccccc2)cc1",
        "output": "567"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC.ClCCl.Clc1ccc(Cl)c(CBr)c1.Nc1ncccc1O.O.[Cl-].[Na+].[OH-]>>Nc1ncccc1OCc1cc(Cl)ccc1Cl",
        "output": "623"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CC(C)(O)c1cc(Br)ccn1.CN(C)C=O.c1c[nH]cn1>>CC(C)(O[Si](C)(C)C(C)(C)C)c1cc(Br)ccn1",
        "output": "193"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(NC(=O)c2ccc(-c3csc(NC(=O)C4CCCN4C(=O)OCc4ccccc4)n3)cc2)CC1.CC(C)(C)OC(=O)N1CCCC(NC(=O)c2ccc(-c3csc(NC(=O)C4CCCN4C(=O)OCc4ccccc4)n3)cc2)C1.ClCCl.O=C(O)C(F)(F)F>>O=C(NC1CCNCC1)c1ccc(-c2csc(NC(=O)C3CCCN3C(=O)OCc3ccccc3)n2)cc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(CC(=O)c1ccc(Sc2ccccc2)cc1)(NC(C)=O)C(=O)OCC.ClCCl.O=C(Cl)CCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CCOC(=O)C(CC(=O)c1ccc(Sc2ccc(C(=O)CCl)cc2)cc1)(NC(C)=O)C(=O)OCC",
        "output": "31"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.O.O=C([O-])[O-].OCC1CCNCC1.[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCC(CO)CC1",
        "output": "694"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)CC1(c2ccc(OCc3cccc(-c4c(C)cc(OCCCS(C)(=O)=O)cc4C)c3)cc2)CN(S(C)(=O)=O)C1.CO.O.[Li+].[OH-]>>Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc(C3(CC(=O)O)CN(S(C)(=O)=O)C3)cc2)c1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCN1CC(C)(C)OC(=O)C1CC(=O)O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1ccc2scnc2c1>>CCN1CC(C)(C)OC(=O)C1CC(=O)Nc1ccc2scnc2c1",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.O=C(O)c1ccc(O)cc1>>CC(=O)Oc1ccc(C(=O)O)cc1",
        "output": "46"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCc2cc(NC(=O)OCc3cc(Cl)cc(Cl)c3)ccc2C1.CC(C)O.CCCO.CCOCC.Cl>>O=C(Nc1ccc2c(c1)CCNC2)OCc1cc(Cl)cc(Cl)c1",
        "output": "887"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.CS(=O)(=O)OCCCn1c(=O)[nH]c2cc(Cl)ccc21.O=C([O-])[O-].O=C1NCN(c2ccccc2)C12CCNCC2.[Na+].[Na+]>>O=C1NCN(c2ccccc2)C12CCN(CCCn1c(=O)[nH]c3cc(Cl)ccc31)CC2",
        "output": "496"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.CCO.O=C(OC[C@H]1C[C@@H](O)[C@@H](n2cc(F)c(=O)[nH]c2=O)O1)c1ccccc1.c1ccncc1>>CC(=O)O[C@@H]1C[C@H](COC(=O)c2ccccc2)O[C@@H]1n1cc(F)c(=O)[nH]c1=O",
        "output": "254"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "B.N#Cc1cccc(CO[C@H]2CCOC2)n1>>NCc1cccc(CO[C@H]2CCOC2)n1",
        "output": "205"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COc1cnc([N+](=O)[O-])c(Nc2cnc3c(c2)CCC(NC(=O)OC(C)(C)C)C3)c1.[Pd]>>COc1cnc(N)c(Nc2cnc3c(c2)CCC(NC(=O)OC(C)(C)C)C3)c1",
        "output": "457"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)CCC(NC(=O)c1ccc(Nc2ncccn2)cc1)C(N)=O.CC(Cl)Cl.O=C(O)C(F)(F)F>>NC(=O)C(CCC(=O)O)NC(=O)c1ccc(Nc2ncccn2)cc1",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CN(C)C=O.Nc1cc(F)ccc1C(=O)O.O=C(Br)CBr>>O=C(CBr)Nc1cc(F)ccc1C(=O)O",
        "output": "442"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.FC(F)(F)Oc1ccc2ncccc2c1.OO.[NH4+].[OH-]>>[O-][n+]1cccc2cc(OC(F)(F)F)ccc21",
        "output": "396"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=C(Br)CBr.CCOC(C)=O.CN(C)C=O.COC(=O)/C=C/c1ccc(OCc2sc(-c3ccc(C)cc3)nc2C)cc1O.O.O=C([O-])[O-].[Cs+].[Cs+]>>C=C(Br)COc1cc(OCc2sc(-c3ccc(C)cc3)nc2C)ccc1/C=C/C(=O)OC",
        "output": "77"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)NCC(O)CNC(C)=O.CC(C)(C)[Si](C)(C)Cl.CCOCC.CN(C)C=O.O.c1c[nH]cn1>>CC(=O)NCC(CNC(C)=O)O[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(NC1C2CC3CC(C2)CC1C3)c1cccc(Br)n1.[Na+].[Pd].[Pd]>>CC(C)(C)OC(=O)N1CCN(c2cccc(C(=O)NC3C4CC5CC(C4)CC3C5)n2)CC1",
        "output": "647"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Cl.Nc1ccc(-c2ccc(C(=O)O)cc2)cc1>>COc1ccc2nc(Nc3ccc(-c4ccc(C(=O)O)cc4)cc3)c3n[nH]cc3c2c1",
        "output": "998"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1nc(/C=C/c2c(-c3ccc(F)cn3)noc2C)sc1C(=O)O.NC1CC1.O>>Cc1nc(/C=C/c2c(-c3ccc(F)cn3)noc2C)sc1C(=O)NC1CC1",
        "output": "534"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrP(Br)Br.C1CCOC1.OCc1ccc(O)cc1.c1ccncc1>>Oc1ccc(CBr)cc1",
        "output": "300"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)Cc1ccc(CC)c(O)c1.CN1CCCC1=O.Cl.Fc1cc(Cl)ccc1Br.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)Cc1ccc(CC)c(Oc2cc(Cl)ccc2Br)c1",
        "output": "564"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CON.C[C@@H](O[C@H]1CCN(C(=O)[C@@H]2CC[C@@H](C(=O)O)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CONC(=O)[C@@H]1CC[C@@H](C(=O)N2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1",
        "output": "480"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1[nH]c2c(c1C)N(C)NCC2.O=C(O)c1cc2ncc(Br)cn2n1>>Cc1[nH]c2c(c1C)N(C)N(C(=O)c1cc3ncc(Br)cn3n1)CC2",
        "output": "995"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@H](C(=O)N1c2ncccc2C[C@@H]1C(=O)Nc1ccccc1)C1CCCCC1.ClCCl.O=C(O)C(F)(F)F>>N[C@H](C(=O)N1c2ncccc2C[C@@H]1C(=O)Nc1ccccc1)C1CCCCC1",
        "output": "431"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCN(C)C(=O)[C@@H]1C[C@H]1C(=O)OCC.[Li+].[OH-]>>CCCN(C)C(=O)[C@@H]1C[C@H]1C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.CCOC(=O)c1cncc(-c2ccc(N3CCC(O)CC3)nn2)c1.Oc1cc(F)ccc1Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1cncc(-c2ccc(N3CCC(Oc4cc(F)ccc4Br)CC3)nn2)c1",
        "output": "846"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)O.Oc1ccc2ccccc2c1>>CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)Oc1ccc2ccccc2c1",
        "output": "108"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.CNC.Cc1cccc(C)c1Nc1nn(CCC2CO2)c2nc(Nc3ccccc3)ncc12>>Cc1cccc(C)c1Nc1nn(CCC(O)CN(C)C)c2nc(Nc3ccccc3)ncc12",
        "output": "76"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CNCC(O)C(O)C(O)C(O)CO.O=C1C(CCC(O)c2ccc(F)cc2)C(c2ccc(OCCOCCOCCI)cc2)N1c1ccc(F)cc1>>CN(CCOCCOCCOc1ccc(C2C(CCC(O)c3ccc(F)cc3)C(=O)N2c2ccc(F)cc2)cc1)CC(O)C(O)C(O)C(O)CO",
        "output": "184"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COc1ccc([N+](=O)[O-])c(CC(=O)NC2CCN(Cc3ccccc3)CC2)c1.C[Si](C)(C)Cl.Cl.O.[BH4-].[Li+]>>COc1ccc([N+](=O)[O-])c(CCNC2CCN(Cc3ccccc3)CC2)c1",
        "output": "112"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "O=C(NC(=S)Nc1ncc(Br)cc1Oc1ccc(F)cc1)c1ccccc1.[Na+].[OH-]>>NC(=S)Nc1ncc(Br)cc1Oc1ccc(F)cc1",
        "output": "80"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CC#N.CCN(C(C)C)C(C)C.Fc1ccc(CBr)c(Br)c1>>Fc1ccc(CN2CCOCC2)c(Br)c1",
        "output": "248"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COc1cc(-c2ccc(C)s2)c2cc(C(O)(c3ccc(Cl)cc3)c3cncn3C)ccc2n1.Cl>>Cc1ccc(-c2cc(=O)[nH]c3ccc(C(O)(c4ccc(Cl)cc4)c4cncn4C)cc23)s1",
        "output": "758"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)C1CCC(c2ncc(-c3ccc(N)cc3)o2)CC1.COC(=O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1.O=C=Nc1ccccc1Cl>>COC(=O)C1CCC(c2ncc(-c3ccc(NC(=O)Nc4ccccc4Cl)cc3)o2)CC1",
        "output": "473"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(C(=O)N[C@@H](CO)C(C)C)cc1.Cl.NO.O=C([O-])O.[Na+]>>Cc1ccccc1C(C/C(=N\\O)c1ccc(=O)n(C)c1)c1ccc(C(=O)N[C@@H](CO)C(C)C)cc1",
        "output": "966"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=C(O)c1cc2c([nH]c1=O)OCc1ccccc1-2.O=S(Cl)Cl>>COC(=O)c1cc2c([nH]c1=O)OCc1ccccc1-2",
        "output": "521"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)c1cn(-c2ccc(CN3CCCC3)cc2F)c2c(Cl)c(F)c(F)cc2c1=O.CS(C)=O.N#Cc1ccccc1N1CCNCC1>>CCOC(=O)c1cn(-c2ccc(CN3CCCC3)cc2F)c2c(Cl)c(N3CCN(c4ccccc4C#N)CC3)c(F)cc2c1=O",
        "output": "676"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOc1nc2c(Cl)nc3ccccc3c2[nH]1.CO.N>>CCOc1nc2c(N)nc3ccccc3c2[nH]1",
        "output": "682"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCC(=O)CC1.CO.Fc1cccc2[nH]ccc12.[K+].[OH-]>>CN1CC=C(c2c[nH]c3cccc(F)c23)CC1",
        "output": "607"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCNCCC.O=C(O)Cn1c(-c2cccc(Br)c2)nc2cccnc21.O=C(n1ccnc1)n1ccnc1>>CCCN(CCC)C(=O)Cn1c(-c2cccc(Br)c2)nc2cccnc21",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)C(C)(c1ccc(Br)cc1)C1CC1.COC(=O)c1ccccc1.O.[K+].[OH-]>>CC(C(=O)O)(c1ccc(Br)cc1)C1CC1",
        "output": "203"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)C1=C(C2CCCO2)CS[C@@H]2[C@H](N)C(=O)N12.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CO/N=C(\\C(=O)O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1.CS(=O)(=O)Cl.Cl.c1ccncc1>>CO/N=C(\\C(=O)N[C@@H]1C(=O)N2C(C(=O)OC(C)(C)C)=C(C3CCCO3)CS[C@H]12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1",
        "output": "587"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CCOC(=O)Cc1cccc(O)c1.COCCCN1CCOc2ccc(COC3CN(C(=O)OCc4ccccc4)CCC3c3ccc(CO)cc3)cc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)Cc1cccc(OCc2ccc(C3CCN(C(=O)OCc4ccccc4)CC3OCc3ccc4c(c3)N(CCCOC)CCO4)cc2)c1",
        "output": "347"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CC(=O)OCCCCCBr.O=C([O-])[O-].O=Cc1ccccc1O.[K+].[K+]>>CC(=O)OCCCCCOc1ccccc1C=O",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.CCN=C=NCCCN(C)C.CCO.Cl.Nc1ccc(C(=O)O)cn1.On1nnc2ccccc21>>Nc1ccc(C(=O)N2CCOCC2)cn1",
        "output": "256"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCO.Cc1ccc2ncc(Oc3c(Cl)cc([N+](=O)[O-])cc3Cl)cc2c1.O.[Cl-].[Fe].[NH4+]>>Cc1ccc2ncc(Oc3c(Cl)cc(N)cc3Cl)cc2c1",
        "output": "335"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CCNC.CN(C)C=O.Cl.O.O=C(O)c1cc(O)c2ccccc2n1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CCN(C)C(=O)c1cc(O)c2ccccc2n1",
        "output": "605"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.O=[N+]([O-])c1ccc(CCCCO)cc1>>O=CCCCc1ccc([N+](=O)[O-])cc1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOCC.COc1ccc(S(=O)(=O)N2CCCC2C(=O)O)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1ccc(S(=O)(=O)N2CCCC2CO)cc1",
        "output": "218"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Cl.CCN(CC)CC.CON(C)C(=O)C(CC(=O)OC(C)(C)C)NS(=O)(=O)c1ccc(N)cc1OCCc1cccc2ccccc12.ClCCl>>CON(C)C(=O)C(CC(=O)OC(C)(C)C)NS(=O)(=O)c1ccc(NC(C)=O)cc1OCCc1cccc2ccccc12",
        "output": "9"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Fc1ccc(Cl)cc1.OC1CN(C(c2ccccc2)c2ccccc2)C1.[H-].[H][H].[Na+]>>Clc1ccc(OC2CN(C(c3ccccc3)c3ccccc3)C2)cc1",
        "output": "485"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)Oc1ccccc1N1CCNCC1.CC(Cl)Cl.O=Cc1cc(Br)cs1.[Na+]>>CC(C)Oc1ccccc1N1CCN(Cc2cc(Br)cs2)CC1",
        "output": "792"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cc1nccn1-c1ccc(Nc2nc3c(c(N4c5ccccc5C[C@H]4CO)n2)CN(C(=O)OC(C)(C)C)CC3)cc1.Cl>>Cc1nccn1-c1ccc(Nc2nc3c(c(N4c5ccccc5C[C@H]4CO)n2)CNCC3)cc1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCNCC.COCCCl.O.[Na+].[OH-]>>CCN(CC)CCOC",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)[C@@H](C=C(c2ccccc2)c2ccccc2)[C@@H]1C(=O)[O-].CO.O.[Na+].[OH-]>>CC1(C)[C@@H](C=C(c2ccccc2)c2ccccc2)[C@@H]1C(=O)O",
        "output": "151"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1=CCCC2OC2CCC=CCC1.O=C1CCCCCCCCCCC1.[H][H]>>OC1CCCCCCCCCCC1",
        "output": "91"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1cnc2cccnc2c1.ClCCl.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1cccc2ncc(Br)cc21",
        "output": "820"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.Cl.N[C@H](Cc1cc(Br)c(O)c(Br)c1)C(=O)N1CCC(N2CCCCC2)CC1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>N[C@H](Cc1cc(Br)c(O)c(Br)c1)CN1CCC(N2CCCCC2)CC1",
        "output": "112"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Cc1c(O)ccc2c1CCN2C(=O)OC(C)(C)C.FC(F)(F)c1cc(CCl)ccc1C1CCCC1.O=C([O-])[O-].[K+].[K+]>>Cc1c(OCc2ccc(C3CCCC3)c(C(F)(F)F)c2)ccc2c1CCN2C(=O)OC(C)(C)C",
        "output": "49"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCCC1=O.Cl.F[P-](F)(F)(F)(F)F.N[C@@H]1CC[C@H](n2c(=O)c3cc(F)cnc3n(-c3ccc(F)c(F)c3)c2=O)CC1.O=C(O)c1cc(CO)ccc1O.On1nnc2cccnc21>>O=C(N[C@H]1CC[C@@H](n2c(=O)c3cc(F)cnc3n(-c3ccc(F)c(F)c3)c2=O)CC1)c1cc(CO)ccc1O",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(Cc1ccccc1)C[C@H](NC(=O)OC(C)(C)C)c1ccccc1.CO.[Pd]>>CNC[C@H](NC(=O)OC(C)(C)C)c1ccccc1",
        "output": "84"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CC(C)(C)[O-].CN1CCCC1CCCl.Cl.Oc1ccccc1CCc1ccccc1.[K+]>>CN1CCCC1CCOc1ccccc1CCc1ccccc1",
        "output": "74"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)N.CCN=C=NCCCN(C)C.CN(C)C=O.C[Si](C)(C)CCOCn1cc(C(=O)O)c(-c2nc3c(s2)CCC3)n1.Cl.On1nnc2ccccc21>>CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)nc1-c1nc2c(s1)CCC2",
        "output": "621"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CN(C(=O)CCCCl)C1CCCCC1.O=C1CCc2c(O)cccc2N1.[Cl-].[I-].[K+].[Na+].c1ccncc1>>CN(C(=O)CCCOc1cccc2c1CCC(=O)N2)C1CCCCC1",
        "output": "74"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1cnc(Br)cn1.COCCOC.Cl[Pd]Cl.O=C([O-])[O-].OB(O)c1ccc(OCc2ccccc2)cc1F.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COC(=O)c1cnc(-c2ccc(OCc3ccccc3)cc2F)cn1",
        "output": "876"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)S(=O)(=O)c1cc(N2CCOCC2)ccc1Nc1nc(Cl)ncc1Cl.COCCN1CCc2ccc(N)cc2CC1>>COCCN1CCc2ccc(Nc3ncc(Cl)c(Nc4ccc(N5CCOCC5)cc4S(=O)(=O)N(C)C)n3)cc2CC1",
        "output": "808"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)C1CNc2cc(Cc3cc([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)ccc3Cl)ccc2O1.O.[Li+].[OH-]>>O=C(O)C1CNc2cc(Cc3cc([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)ccc3Cl)ccc2O1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCc1cc2cc(C(=O)O)ccc2o1.CCN(C(C)C)C(C)C.CN(C)c1ccncc1.COC(=O)Cc1ccc(-c2csc(N)n2)s1.ClCCl.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>COC(=O)Cc1ccc(-c2csc(NC(=O)c3ccc4oc(CNC(=O)OC(C)(C)C)cc4c3)n2)s1",
        "output": "918"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCCCBr.CN(C)C=O.COC(=O)Cn1ccc2cc(O)ccc21.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)Cn1ccc2cc(OCCCBr)ccc21",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)C(C)(C)c1cn2nc(CCCN3CCC(OC(c4ccccc4)c4ccccc4)CC3)ccc2n1.Cl.Cl.[Na+].[OH-]>>CC(C)(C(=O)O)c1cn2nc(CCCN3CCC(OC(c4ccccc4)c4ccccc4)CC3)ccc2n1",
        "output": "615"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2ccc(OCCCCl)cc2)cc1.O.[Li+].[OH-]>>O=C(O)c1ccc(-c2ccc(OCCCCl)cc2)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCC/C=C\\CCCCCCCC(=O)[O-].CCCCCCCC/C=C\\CCCCCCCC(=O)[O-].CCCCCCCC/C=C\\CCCCCCCC(=O)[O-].CCCCCCCC/C=C\\CCCCCCCCO.[In+3].[In+3].[In+3].[O-2].[O-2].[O-2]>>CCCCCCCC/C=C\\CCCCCCCC(=O)O",
        "output": "151"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)CC1.CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.CC(C)(C)[Si](C)(C)OCCc1ccc(O)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(CCO[Si](C)(C)C(C)(C)C)cc2)CC1",
        "output": "846"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NC1CCN(Cc2ccccc2)CC1.O=C(O)c1cc2cc(O)ccc2[nH]1.On1nnc2ccccc21>>O=C(NC1CCN(Cc2ccccc2)CC1)c1cc2cc(O)ccc2[nH]1",
        "output": "137"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.O=C([O-])[O-].O=Cc1ccc(F)cc1.[K+].[K+].c1ccncc1>>CC(C)(C)OC(=O)N1CCN(c2ccc(C=O)cc2)CC1",
        "output": "26"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(C(=O)c2cccc(C(=O)c3ccc(OC)cc3)c2)cc1.CSC.ClCCl.FB(F)F>>COc1ccc(C(=O)c2cccc(C(=O)c3ccc(O)cc3)c2)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COc1cc(C(F)(F)F)c(CO)cn1.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>COc1cc(C(F)(F)F)c(C=O)cn1",
        "output": "520"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cc1c([N+](=O)[O-])ccc(F)c1F.Cl.ClCCl.O.OCc1ccccc1.[Li]O>>CC(=O)Cc1c([N+](=O)[O-])ccc(OCc2ccccc2)c1F",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc2nnc(C(N)=O)c(Nc3ccc(C)cc3F)c2cc1C1=CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>COc1cc2nnc(C(N)=O)c(Nc3ccc(C)cc3F)c2cc1C1=CCNCC1",
        "output": "800"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CNCCN(C)C.O=C(CCl)Nc1ccc2oc3c(c2c1)CCCCC3.O=C([O-])[O-].[Cs+].[Cs+]>>CN(C)CCN(C)CC(=O)Nc1ccc2oc3c(c2c1)CCCCC3",
        "output": "340"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.OC1CCN(CC23CC(c4ccccc42)c2ccccc23)CC1>>O=C1CCN(CC23CC(c4ccccc42)c2ccccc23)CC1",
        "output": "87"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(Nc1ncnc2cc(C(=O)O)c(Cl)cc12)c1nc2cc(Cl)ccc2[nH]1.CCN(C(C)C)C(C)C.CN(C)C(Oc1c(F)c(F)c(F)c(F)c1F)=[N+](C)C.CS(C)=O.F[P-](F)(F)(F)(F)F.c1ccc(CCC2CCCN2)cc1>>CC(Nc1ncnc2cc(C(=O)N3CCCC3CCc3ccccc3)c(Cl)cc12)c1nc2cc(Cl)ccc2[nH]1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(OCC)[C@H](C)N(Cc1csc2ccccc12)C(=O)[C@@H](N)CCCCNC(=O)OC(C)(C)C.O=C(O)CONC(=O)NCc1ccncc1>>CCOC(OCC)[C@H](C)N(Cc1csc2ccccc12)C(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)CONC(=O)NCc1ccncc1",
        "output": "133"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#CCN(C)C.CN(C(=O)c1cc2c(s1)-c1ccc(Br)cc1OCC2)c1ccccc1Cl>>CN(C)CC#Cc1ccc2c(c1)OCCc1cc(C(=O)N(C)c3ccccc3Cl)sc1-2",
        "output": "659"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrC(Br)(Br)Br.ClCCl.O=[N+]([O-])c1ccccc1CCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=[N+]([O-])c1ccccc1CCBr",
        "output": "378"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1nc(Cl)nc(Cl)c1[N+](=O)[O-].CCOC(C)=O.O.O=C([O-])[O-].[Na+].[Na+]>>CCOC(=O)c1nc(Cl)nc(Cl)c1N",
        "output": "660"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1ccc([N+](=O)[O-])c(C(=O)c2ccc(C(C)C)cc2)c1.[Ni]>>COc1ccc(N)c(C(=O)c2ccc(C(C)C)cc2)c1",
        "output": "202"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "N#Cc1c([N+](=O)[O-])cccc1[N+](=O)[O-].OCc1ccoc1>>N#Cc1c(OCc2ccoc2)cccc1[N+](=O)[O-]",
        "output": "499"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)C(=O)Cl.C[C@@H](CO)[C@H]1CC[C@H]2[C@@H](O)CCC[C@]12C.ClCCl.c1ccncc1>>C[C@@H](COC(=O)C(C)(C)C)[C@H]1CC[C@H]2[C@@H](O)CCC[C@]12C",
        "output": "126"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)[C@H](C/C=C/c1ccc(N(c2ncccn2)C(C)C)cc1)NC(=O)c1c(Cl)cccc1Cl.O.[Li+].[OH-]>>CC(C)N(c1ccc(/C=C/C[C@H](NC(=O)c2c(Cl)cccc2Cl)C(=O)O)cc1)c1ncccn1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(N)CO.COC(=O)c1ccc(OCc2c(C3CCCCC3)noc2C)nc1>>Cc1onc(C2CCCCC2)c1COc1ccc(C(=O)NC(C)(C)CO)cn1",
        "output": "862"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCc1cc(NC(=O)Oc2ccccc2)c(OC)nc1C.Fc1ccc(N2CCNCC2)cc1>>CCc1cc(NC(=O)N2CCN(c3ccc(F)cc3)CC2)c(OC)nc1C",
        "output": "525"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCCOC(=O)c1ccc2c(c1)CCC2N[C@@H]1CC[C@@H](C(C)(C)C)CC1.CCN(CC)CC.CN(C)c1ccncc1.ClCCl>>CCCCOC(=O)c1ccc2c(c1)CCC2N(C(=O)OC(C)(C)C)[C@@H]1CC[C@@H](C(C)(C)C)CC1",
        "output": "867"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(c1cc(OC(F)(F)F)cc2cc(C(=O)O)[nH]c12)S(=O)(=O)c1cccs1.COC(OC)C(CN)SCc1ccccc1.F[P-](F)(F)(F)(F)F.O>>COC(OC)C(CNC(=O)c1cc2cc(OC(F)(F)F)cc(N(C)S(=O)(=O)c3cccs3)c2[nH]1)SCc1ccccc1",
        "output": "137"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.O=[N+]([O-])c1ccc(-n2nc(C(F)(F)F)cc2-c2ccco2)cc1.[Pd]>>Nc1ccc(-n2nc(C(F)(F)F)cc2-c2ccco2)cc1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cnn2c3ccc(N)cc3c(=O)n(C)c12.O.S=C=Nc1ccccc1.c1ccncc1>>CCOC(=O)c1cnn2c3ccc(NC(=S)Nc4ccccc4)cc3c(=O)n(C)c12",
        "output": "474"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1ccc(-c2nc3ccc(Br)cc3s2)cc1.O.[Cl-].[Na+]>>Oc1ccc(-c2nc3ccc(Br)cc3s2)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CC[C@H](NC(=O)C1Cc2cc3c(cc2CN1C(=O)OC(C)(C)C)O[C@@H](c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)CO3)C(=O)OC.CC(C)(C)OC(=O)N1Cc2cc3c(cc2CC1C(=O)O)OC[C@H](c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)O3.N#Cc1ccc(I)cc1>>COC(=O)[C@H](CC#Cc1ccc(C#N)cc1)NC(=O)C1Cc2cc3c(cc2CN1C(=O)OC(C)(C)C)O[C@@H](c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)CO3",
        "output": "664"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCOC(=O)C[C@@H]1O[C@@H](c2cccc(OC)c2OC)c2cc(C#N)ccc2-n2c1nnc2C(F)(F)F.Cl>>COc1cccc([C@H]2O[C@H](CC(=O)O)c3nnc(C(F)(F)F)n3-c3ccc(C#N)cc32)c1OC",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC(=O)O.Cl.Nc1cc(Cl)c(S(N)(=O)=O)cc1N.[NH4+].[OH-]>>CCCc1nc2cc(Cl)c(S(N)(=O)=O)cc2[nH]1",
        "output": "512"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cc1ccc(-c2ccc(C(CC)(CC)c3ccc(CCC(O)C(C)(C)C)c(C)c3)cc2C)nc1.CO.Cl.O.[Na+].[OH-]>>CCC(CC)(c1ccc(CCC(O)C(C)(C)C)c(C)c1)c1ccc(-c2ccc(CC(=O)O)cn2)c(C)c1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.COCCOCCOCCOCCO.CS(=O)(=O)Cl.ClCCl>>COCCOCCOCCOCCOS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CO.Cc1c(C(=O)O)cc([N+](=O)[O-])cc1[N+](=O)[O-].Cc1ccccc1.O.O=S(=O)(O)O.[Na+].[OH-]>>COC(=O)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1C",
        "output": "195"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(C)=O.Cn1cc(C2=C(c3cn(CCCOS(C)(=O)=O)c4ccccc34)C(=O)NC2=O)c2ccccc21.O.[C-]#N.[Na+]>>Cn1cc(C2=C(c3cn(CCCC#N)c4ccccc34)C(=O)NC2=O)c2ccccc21",
        "output": "705"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.Cl.ClC(Cl)Cl.Cl[Sn](Cl)(Cl)Cl.N.Nc1ccc(-c2cn3ccccc3n2)cc1.O.O.O.O=N[O-].[Na+]>>NNc1ccc(-c2cn3ccccc3n2)cc1",
        "output": "109"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CNC1CCc2cc(OC)c(OC)cc2C1.O=C1Cc2cc3c(cc2CCN1CCCCl)OCCO3>>COc1cc2c(cc1OC)CC(N(C)CCCN1CCc3cc4c(cc3CC1=O)OCCO4)CC2",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cc1ccc(C)cc1.O=S(=O)(O)Cl>>CCOC(=O)Cc1ccc(C)c(S(=O)(=O)Cl)c1",
        "output": "182"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC)CC.CN1CCCC1=O.CN1c2cc(-c3cc(CO)ccc3C#N)ccc2N(CC2CC2(F)F)S1(=O)=O.CS(=O)(=O)Cl.Oc1noc2c1CNCC2>>CN1c2cc(-c3cc(CN4CCc5onc(O)c5C4)ccc3C#N)ccc2N(CC2CC2(F)F)S1(=O)=O",
        "output": "765"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc2c(Cl)ncnc2cc1OCC1CCN(CCS(C)(=O)=O)CC1.Cc1ccc2ccc(O)cc2n1>>COc1cc2c(Oc3ccc4ccc(C)nc4c3)ncnc2cc1OCC1CCN(CCS(C)(=O)=O)CC1",
        "output": "668"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1ccc2c(Cl)ccnc2c1.[BH4-].[Na+]>>OCc1ccc2c(Cl)ccnc2c1",
        "output": "444"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cc1csc2ncnc(C#N)c12.Cl.ClCCl.[Pd]>>Cc1csc2ncnc(CN)c12",
        "output": "205"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1cccc([C@@H]2CC[C@@H](N)CC2)c1.CN1CCOCC1.Cc1[nH]c(C(=O)O)c(Cl)c1Cl.ClCCCl.ClCCl.On1nnc2ccccc21>>CCOC(=O)c1cccc([C@@H]2CC[C@@H](NC(=O)c3[nH]c(C)c(Cl)c3Cl)CC2)c1",
        "output": "137"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.C[O-].Nc1ncc(F)cc1-c1cc(Cl)ncc1Cl.[Na+]>>COc1cc(-c2cc(F)cnc2N)c(Cl)cn1",
        "output": "433"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1ccc(C(=O)CCCCCBr)cc1.COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1.Cl.Cl.O=C([O-])[O-].[K+].[K+]>>CCc1ccc(C(=O)CCCCCN2CCC(CNC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cc1ccccc1.O=C(O)c1ccc(C=Cc2ccccc2)cc1.O=S(Cl)Cl>>O=C(Cl)c1ccc(C=Cc2ccccc2)cc1",
        "output": "3"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(=O)COc1c(C(=O)OC)sc2c1sc1cc(C(=O)O)ccc12.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCC1CCCCC1>>CCOC(=O)COc1c(C(=O)OC)sc2c1sc1cc(C(=O)NCC3CCCCC3)ccc12",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)C=O.Nc1n[nH]c2c1CCC2.O=C(Cl)C(=O)Cl.O=C(O)Cc1ccc(-c2cccc(F)c2)cc1>>O=C(Cc1ccc(-c2cccc(F)c2)cc1)Nc1n[nH]c2c1CCC2",
        "output": "795"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNCC1.C1COCCO1.CS(=O)(=O)OCCCN1CCN(C2CCN(C3CC3)CC2)C1=C(C#N)C#N.O.O=C([O-])[O-].[K+].[K+]>>N#CC(C#N)=C1N(CCCN2CCCCC2)CCN1C1CCN(C2CC2)CC1",
        "output": "496"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.N[C@@H](Cc1cc(F)cc(F)c1)c1ncc(Br)cc1Br>>CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)c1ncc(Br)cc1Br",
        "output": "631"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(C)(C)C(O)(c1cncnc1)c1ccc(Br)cn1.OB(O)c1ccc(OC(F)(F)F)cc1>>CCC(C)(C)C(O)(c1cncnc1)c1ccc(-c2ccc(OC(F)(F)F)cc2)cn1",
        "output": "833"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "O=c1cc(OCc2ccc(Cl)cn2)cn[nH]1.O=c1cc(OCc2ccc(F)cc2)cnn1C1CCCCO1>>O=c1cc(OCc2ccc(F)cc2)cn[nH]1",
        "output": "689"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.O=C1CCc2cc(C(=O)CCN3CCC(c4ccccc4)CC3)ccc2N1.[C].[H][H].[Pd]>>O=C1CCc2cc(C(O)CCN3CCC(c4ccccc4)CC3)ccc2N1",
        "output": "24"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)NC(C)C.Fc1ccc(Cl)cc1Br.O=C=O.[Li]CCCC>>O=C(O)c1cc(Cl)cc(Br)c1F",
        "output": "387"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)CC(C)C.O=C([O-])[O-].O=c1[nH]c2ccccc2n1CCBr.OC(c1ccccc1)(c1ccccc1)C1CCNCC1.[I-].[Na+].[Na+].[Na+]>>O=c1[nH]c2ccccc2n1CCN1CCC(C(O)(c2ccccc2)c2ccccc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.Cc1cccc(C)n1.ClCCl.Cn1nccc1[C@H]1CC[C@H](O)C[C@@H]1OC(=O)c1ccccc1>>Cn1nccc1[C@H]1CC[C@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1OC(=O)c1ccccc1",
        "output": "839"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cl.N#Cc1ccc2[nH]cc(CC3CCN(Cc4ccccc4)C3)c2c1>>N#Cc1ccc2[nH]cc(CC3CCNC3)c2c1",
        "output": "84"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.COCCOc1cc2nccc(Oc3ccc(N)c(F)c3)c2cc1C#N.CS(=O)(=O)c1cccc(NC(=O)Oc2ccccc2)c1.Cc1ccccc1>>COCCOc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(S(C)(=O)=O)c4)c(F)c3)c2cc1C#N",
        "output": "965"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.CC(=O)N(C)C.CCC1=CSC(=C(C#N)c2ccnc(NCCCN)n2)N1.CCN(CC)CC>>CCC1=CSC(=C(C#N)c2ccnc(NCCCNC(C)=O)n2)N1",
        "output": "45"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.ClC(Cl)Cl.O=C1CSc2ccc(CO)cc2N1.O=[Mn]=O>>O=Cc1ccc2c(c1)NC(=O)CS2",
        "output": "179"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCCCC.CCOC(C)=O.COCCl.Cc1cccc(C(C)(C)C)c1O.[Cl-].[H-].[NH4+].[Na+]>>COCOc1c(C)cccc1C(C)(C)C",
        "output": "375"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Cc1cc(O)cc(C)c1C(=O)CBr.NC(N)=S>>Cc1cc(O)cc(C)c1-c1csc(N)n1",
        "output": "716"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.CCOC(=O)c1nc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2)nc1CO.Oc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1nc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2)nc1COc1ccccc1",
        "output": "550"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCNCCc1ccc(Cl)cc1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COC(=O)c1ccccc1COc1ccc(CC(=O)O)cc1.F[B-](F)(F)F>>CCCCCCCN(CCc1ccc(Cl)cc1)C(=O)Cc1ccc(OCc2ccccc2C(=O)OC)cc1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.Cl.N#CC(Cc1ccc([N+](=O)[O-])cc1)c1ccccc1.[Sn]>>N#CC(Cc1ccc(N)cc1)c1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COc1cc(Br)c(OC)c(CO)c1.O.O=S(Cl)Cl.[Cl-].[Cl-].[Zn+2]>>COc1cc(Br)c(OC)c(CCl)c1",
        "output": "81"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.COc1ccc(-c2cc3ccc(O)cc3s2)cc1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>COc1ccc(-c2cc3ccc(OS(=O)(=O)C(F)(F)F)cc3s2)cc1",
        "output": "731"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)[Si](C)(C)O[C@@H](CNCCc1cccc([N+](=O)[O-])c1)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12.CCN(CC)CC.ClCCl>>CC(C)(C)OC(=O)N(CCc1cccc([N+](=O)[O-])c1)C[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CN1C(=O)c2ccccc2C1=O.CC#N.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.COCCc1nc2cnc3ccc(Br)cc3c2n1CCCN1CCCC1=O.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.[Pd+2]>>COCCc1nc2cnc3ccc(C=CN4C(=O)c5ccccc5C4=O)cc3c2n1CCCN1CCCC1=O",
        "output": "539"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cc(N)c2ccccc2n1.Cc1cc(NC(=O)NCCCN2CCC(O)(Cc3ccccc3)CC2)c2ccccc2n1.Cc1cc(NC(=O)NCCCl)c2ccccc2n1.O=C=NCCCCl>>Cc1cc(NC(=O)NCCCCl)c2ccccc2n1",
        "output": "176"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)COc1ccccc1Oc1cc(N)c(F)cc1Cl.COC(=O)Cl.Cl.c1ccncc1>>COC(=O)COc1ccccc1Oc1cc(NC(=O)OC)c(F)cc1Cl",
        "output": "102"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCCN(C)C.CN1CCOCC1.CNOC.Cc1nc(C(F)(F)F)ccc1C(=O)O.Cl.Cl.ClCCl>>CON(C)C(=O)c1ccc(C(F)(F)F)nc1C",
        "output": "879"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CO.Cc1ncnc2c1c(NCc1ccc(O)cc1)cc(=O)n2OCc1ccccc1.[C].[H][H].[Pd]>>Cc1ncnc2c1c(NCc1ccc(O)cc1)cc(=O)n2O",
        "output": "630"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.O=C([O-])[O-].O=[N+]([O-])c1cccc(O)c1.OCCOCCOCCCl.[K+].[K+]>>O=[N+]([O-])c1cccc(OCCOCCOCCO)c1",
        "output": "74"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COC(=O)c1ccc(-c2cc(C)c(OCC(C)=O)c(C)c2)cc1C(C)C.C[C@H](N)[C@H](O)c1ccc(O)cc1.[Na+]>>COC(=O)c1ccc(-c2cc(C)c(OCC(C)N[C@@H](C)[C@H](O)c3ccc(O)cc3)c(C)c2)cc1C(C)C",
        "output": "236"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CN(C)CCN(C)c1nc2cc([N+](=O)[O-])ccc2o1.[Fe]>>CN(C)CCN(C)c1nc2cc(N)ccc2o1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.Cc1cccc(CO)c1[N+](=O)[O-]>>Cc1cccc(C=O)c1[N+](=O)[O-]",
        "output": "179"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CC[C@@H](C(=O)OC(C)C)[C@H](O)C(=O)OC(C)C.CC#N.CC(=O)[O-].CC(=O)[O-].Cc1ccccc1P(c1ccccc1C)c1ccccc1C.FC(F)(F)Oc1ccc(Br)cc1.[Pd+2]>>CC(C)OC(=O)[C@@H](O)[C@@H](C/C=C/c1ccc(OC(F)(F)F)cc1)C(=O)OC(C)C",
        "output": "539"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)Cc1ccc(CCC=O)cc1.CN[C@@H]1CC[C@@H](c2ccc3[nH]c(=O)oc3c2)CC1.Cl>>CC(C)Cc1ccc(CCCN(C)[C@@H]2CC[C@@H](c3ccc4[nH]c(=O)oc4c3)CC2)cc1",
        "output": "484"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cl.ClC(Cl)Cl.O=C([O-])O.O=Cc1ccc2oc(-c3ccc4ccc(Cl)cc4n3)cc2c1.[BH4-].[Na+].[Na+]>>OCc1ccc2oc(-c3ccc4ccc(Cl)cc4n3)cc2c1",
        "output": "356"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.COCOc1cccc2sc(-c3nnc(C)o3)cc12.O>>Cc1nnc(-c2cc3c(O)cccc3s2)o1",
        "output": "755"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCc1nc(N)nc(-c2ccc(C(=O)OC)cc2)c1C#Cc1ccc(N)nc1>>CCc1nc(N)nc(-c2ccc(C(=O)O)cc2)c1C#Cc1ccc(N)nc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COCCN.COc1cc(Cl)cc(C(=O)NCc2ccc(C#N)cc2OCC(=O)O)c1>>COCCNC(=O)COc1cc(C#N)ccc1CNC(=O)c1cc(Cl)cc(OC)c1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.COc1cn(-c2cccc(C(F)(F)F)c2)nc(-c2ccnn2-c2ccccc2)c1=O.C[Si](C)(C)Cl.O.[I-].[Na+]>>O=c1c(O)cn(-c2cccc(C(F)(F)F)c2)nc1-c1ccnn1-c1ccccc1",
        "output": "424"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.ClCCl.Cn1nccc1[C@H]1CC[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1O.O=C(Cl)c1ccccc1>>Cn1nccc1[C@H]1CC[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1OC(=O)c1ccccc1",
        "output": "51"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "N#Cc1ccc(B(O)O)cc1.Nc1cncc(Br)c1.O=C([O-])[O-].[Na+].[Na+]>>N#Cc1ccc(-c2cncc(N)c2)cc1",
        "output": "833"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COCCOC.ClC(Cl)Cl.O=C([O-])[O-].OCCCCCl.Sc1ccccc1.[K+].[K+]>>OCCCCSc1ccccc1",
        "output": "460"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cccc2c1CCC=C2CCC(=O)O.Cl.Cl.O.c1ccncc1>>O=C(O)CCC1=CCCc2c(O)cccc21",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNC1.CC(C)(C)[O-].Cc1ccccc1.Cc1onc(-c2ccccc2)c1COc1ccc(Cl)nn1.[Na+].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Cc1onc(-c2ccccc2)c1COc1ccc(N2CCCC2)nn1",
        "output": "406"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cn(-c2ccc([N+](=O)[O-])cc2F)nn1.Cl[Sn]Cl>>Cc1cn(-c2ccc(N)cc2F)nn1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC[Si](CC)(CC)c1cc(Br)nc([C@@](N)(CO)C(F)F)c1F.ClCCl.O=C(Cl)CCl.O=C([O-])[O-].[Na+].[Na+]>>CC[Si](CC)(CC)c1cc(Br)nc([C@](CO)(NC(=O)CCl)C(F)F)c1F",
        "output": "45"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CNc2ccccc2NC1=O.COc1ccc2c(Br)cccc2c1CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)CNc2ccccc21.COc1ccc2ccccc2c1CBr>>COc1ccc2ccccc2c1CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)CNc2ccccc21",
        "output": "688"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(CO)Oc1ccccc1CO.ClCCl.[Mn+4].[O-2].[O-2]>>CC(CO)Oc1ccccc1C=O",
        "output": "179"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)/C=C/CNCC(=O)OC(C)(C)C.O.[K+].[OH-]>>CC(C)(C)OC(=O)CNC/C=C/C(=O)O",
        "output": "58"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.Cc1cccnc1C(=O)c1ccc(F)c([N+](=O)[O-])c1.[Fe]>>Cc1cccnc1C(=O)c1ccc(F)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1CCNCC1.Cc1c(-c2csc(C=O)c2)sc2c(N3CCOCC3)nc(Cl)nc12>>Cc1c(-c2csc(CN3CCN(C)CC3)c2)sc2c(N3CCOCC3)nc(Cl)nc12",
        "output": "792"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NC1CCC(CNc2nc(Cl)ncc2[N+](=O)[O-])CC1.CCN(C(C)C)C(C)C.CN(C)C=O.CS(=O)(=O)c1ccccc1CN.Cl>>CC(C)(C)OC(=O)NC1CCC(CNc2nc(NCc3ccccc3S(C)(=O)=O)ncc2[N+](=O)[O-])CC1",
        "output": "364"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1=COCCC1.CC#N.CC(=O)Nc1cc(C)[nH]n1.O=C(O)C(F)(F)F>>CC(=O)Nc1cc(C)n(C2CCCCO2)n1",
        "output": "878"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCc1cc(Cl)nc(Nc2ccc(F)c(C#N)c2)n1.Cl.Cl.N[C@@H]1CCCNC1>>CCCCc1cc(N2CCC[C@@H](N)C2)nc(Nc2ccc(F)c(C#N)c2)n1",
        "output": "162"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C1(NC(=O)CC)Cc2cccc3c2N(CCC3)C1=O.CO.Cl.[Na+].[OH-]>>CCC(=O)NC1(C(=O)O)Cc2cccc3c2N(CCC3)C1=O",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)c1ccc(OC(=O)C2CC(=S(=O)=O)c3ccccc3O2)cc1OC.O.O.[Li]O>>COc1cc(OC(=O)C2CC(=S(=O)=O)c3ccccc3O2)ccc1C(=O)O",
        "output": "222"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCOCC.CO.NC1CC1.O=Cc1cc(Br)cc(Cl)c1Cl.[BH3-]C#N.[Na+]>>Clc1cc(Br)cc(CNC2CC2)c1Cl",
        "output": "468"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.COC(=O)CCc1ccc(O)cc1.Cc1ccccc1.OCc1ccc(CCl)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)CCc1ccc(OCc2ccc(CCl)cc2)cc1",
        "output": "347"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC(=O)C(F)C1.CO.[BH4-].[Na+]>>CC(C)(C)OC(=O)N1CCC(O)C(F)C1",
        "output": "91"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=S(Cl)Cl.OCc1ccc2nc(Br)nn2c1>>ClCc1ccc2nc(Br)nn2c1",
        "output": "477"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)O.CCCCCCCCCCCC(=O)Cl.Cl.N=C(N)NCCC[C@H](N)C(=O)O.O.[Na+].[OH-]>>CCCCCCCCCCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)O",
        "output": "585"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOCC.COCCOc1ccc(CCC(=O)[O-])c(OCC2CCCO2)c1.Cc1ccccc1.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[H-].[Na+].[Na+]>>COCCOc1ccc(CCCO)c(OCC2CCCO2)c1",
        "output": "231"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)c1ccc(CCc2cccc3c2N(C(=O)Cc2cccc(OC)c2)CC3)cc1.O=C(O)c1ccc(CCc2cccc3c2N(Cc2cccc(F)c2)CC3)cc1.[Li+].[OH-]>>COc1cccc(CC(=O)N2CCc3cccc(CCc4ccc(C(=O)O)cc4)c32)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(C2CC2)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1ccc(C2CC2)cc1",
        "output": "311"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)cc1N.Cc1ncccc1C(=O)O.Cl.On1nnc2ccccc21>>Cc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)cc1NC(=O)c1cccnc1C",
        "output": "739"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1ccc(CNC[C@H](O[Si](C)(C)C(C)(C)C)c2ccc(OCc3ccccc3)c3[nH]c(=O)ccc23)cc1.ClCCl>>COC(=O)c1ccc(CN(C[C@H](O[Si](C)(C)C(C)(C)C)c2ccc(OCc3ccccc3)c3[nH]c(=O)ccc23)C(=O)OC(C)(C)C)cc1",
        "output": "867"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CCOc1nnc(-c2cc(N)cnc2C)cc1N1CCOCC1.CN(C)C=O.Cl.O=Cc1ccc(C(=O)O)cc1C(F)(F)F>>CCOc1nnc(-c2cc(NC(=O)c3ccc(C=O)c(C(F)(F)F)c3)cnc2C)cc1N1CCOCC1",
        "output": "759"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O.O=Cc1ccc2c(c1)OCCO2.O=[Mn](=O)(=O)[O-].[K+].[K+].[OH-]>>O=C(O)c1ccc2c(c1)OCCO2",
        "output": "384"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O=C(N1CCN(c2cc(S(=O)(=O)Cl)ccc2OCC(F)(F)F)CC1)C(Cl)(Cl)Cl.O=Cc1c[nH]c2cc(Br)ccc12.[H-].[Na+]>>O=Cc1cn(S(=O)(=O)c2ccc(OCC(F)(F)F)c(N3CCN(C(=O)C(Cl)(Cl)Cl)CC3)c2)c2cc(Br)ccc12",
        "output": "648"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(O)C(=O)O.Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2ccccc2)CCNCC1.ClCCCl.O=C([O-])O.O=C(n1ccnc1)n1ccnc1.[Na+]>>Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2ccccc2)CCN(C(=O)C(C)(C)O)CC1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COC(=O)CS(=O)(=O)Nc1c(F)cc(F)cc1F.[Na+].[OH-]>>O=C(O)CS(=O)(=O)Nc1c(F)cc(F)cc1F",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc2c(c1)N(C1CCNCC1)CC2.Fc1ccc(OCCCBr)cc1>>Fc1ccc(OCCCN2CCC(N3CCc4ccc(Br)cc43)CC2)cc1",
        "output": "73"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)c1sc(COC)nc1C.[K+].[OH-]>>COCc1nc(C)c(C(=O)O)s1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN.CO.O=C(CCl)NCCn1c(-c2ccc[nH]2)nc2c(C(F)(F)F)nc3ccccc3c21>>CNCC(=O)NCCn1c(-c2ccc[nH]2)nc2c(C(F)(F)F)nc3ccccc3c21",
        "output": "330"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN.COc1ccccc1N1c2ccccc2N(CCCBr)S1(=O)=O>>CNCCCN1c2ccccc2N(c2ccccc2OC)S1(=O)=O",
        "output": "147"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccccc1.Nc1ccccc1.O=C([O-])[O-].O=[N+]([O-])c1cccnc1Cl.[Na+].[Na+]>>O=[N+]([O-])c1cccnc1Nc1ccccc1",
        "output": "434"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O.CC(C)(C)[Si](OC1CN(c2nc(C(=O)N[C@@H]3CCN(C(=O)OCc4ccc([N+](=O)[O-])cc4)C3)cs2)C1)(c1ccccc1)c1ccccc1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>O=C(N[C@@H]1CCN(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1)c1csc(N2CC(O)C2)n1",
        "output": "781"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CNCC(O)C(Cc1ccccc1)NC(=O)OC1COC2OCCC12.ClCCl.O=C([O-])O.O=S(=O)(Cl)c1ccc2occc2c1.[Na+]>>CC(C)CN(CC(O)C(Cc1ccccc1)NC(=O)OC1COC2OCCC12)S(=O)(=O)c1ccc2occc2c1",
        "output": "99"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCc1cc([N+](=O)[O-])cc2cccnc12.[Pd]>>CCc1cc(N)cc2cccnc12",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cc(Cl)nc2ccccc12.NN>>Cc1cc(NN)nc2ccccc12",
        "output": "417"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.NC(=O)c1cc(-c2ccc(CBr)cc2)no1.O=C([O-])[O-].[K+].[K+].c1ccc2[nH]cnc2c1>>NC(=O)c1cc(-c2ccc(Cn3cnc4ccccc43)cc2)no1",
        "output": "658"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=CCCC[C@H](O)c1ccc(-c2ccc(Cl)cc2Cl)cc1.CCOCC.COCCOCCOC.FB(F)F.O.O=C([O-])[O-].OO.[BH4-].[K+].[K+].[Na+].[Na+].[OH-]>>OCCCCC[C@H](O)c1ccc(-c2ccc(Cl)cc2Cl)cc1",
        "output": "465"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1c(Cl)cc(C(=O)O)cc1C(F)(F)F.Cc1ccccc1.O=S(Cl)Cl>>COc1c(Cl)cc(C(=O)Cl)cc1C(F)(F)F",
        "output": "3"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)c1nsc(N2CCC(N)CC2)n1.CCN(CC)CC.Cl.O=C(Cl)C(Br)CCBr>>CC(C)c1nsc(N2CCC(NC(=O)C(Br)CCBr)CC2)n1",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1ccc2c(C(C)=O)nn(CC(=O)N3[C@H](C(=O)N[C@@H]4C[C@H]4c4ccccc4F)C[C@H]4C[C@H]43)c2c1.O.O.[Li]O>>CC(=O)c1nn(CC(=O)N2[C@H](C(=O)N[C@@H]3C[C@H]3c3ccccc3F)C[C@H]3C[C@H]32)c2cc(C(=O)O)ccc12",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCN1C(=O)C2C(C1=O)C2(CC(F)(F)F)c1cccc([N+](=O)[O-])c1.CCO.O.[Ca+2].[Cl-].[Cl-].[Fe]>>CCCCCCN1C(=O)C2C(C1=O)C2(CC(F)(F)F)c1cccc(N)c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCc1c(O)ccc2c1OCCC2=O.COC(=O)CCCCOc1cccc(CCCCCCOS(C)(=O)=O)c1CCC(=O)OC>>CCCc1c(OCCCCCCc2cccc(OCCCCC(=O)OC)c2CCC(=O)OC)ccc2c1OCCC2=O",
        "output": "702"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCOC(=O)c1cc(C2CCCC2)[nH]n1.Cl.[Na+].[OH-]>>O=C(O)c1cc(C2CCCC2)[nH]n1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CS(=O)(=O)c1ccc(S(=O)(=O)CCC2CCN(CCC(=O)c3ccccc3)CC2)cc1.[BH4-].[Na+]>>CS(=O)(=O)c1ccc(S(=O)(=O)CCC2CCN(CCC(O)c3ccccc3)CC2)cc1",
        "output": "24"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)c1ccc2c(c1O)OCO2.CC(C)=O.CC(C)I.Cl.O.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1ccc2c(c1OC(C)C)OCO2",
        "output": "318"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.O=CCCc1cc(-c2cccs2)no1.[Na+].c1ccc(N2CCNCC2)cc1>>c1ccc(N2CCN(CCCc3cc(-c4cccs4)no3)CC2)cc1",
        "output": "484"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.Cn1cc(C2=C(c3cccc([N+](=O)[O-])c3)C(=O)NC2=O)c2ccccc21.[Na+].[OH-]>>Cn1cc(C2=C(c3cccc(N)c3)C(=O)NC2=O)c2ccccc21",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COc1cccc(CBr)c1.O=C([O-])[O-].O=Cc1cc(Br)c(O)c(Br)c1.[I-].[K+].[K+].[K+]>>COc1cccc(COc2c(Br)cc(C=O)cc2Br)c1",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.ClCCl.OCC1CCCN1.[K+].[OH-]>>CC(=O)N1CCCC1CO",
        "output": "125"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CN(c1nnc(-c2ccc(F)cc2Cl)s1)C1CC(C)(C)NC(C)(C)C1.ClCCl.O=C([O-])[O-].[Cs+].[Cs+].c1cn[nH]c1>>CN(c1nnc(-c2ccc(-n3cccn3)cc2Cl)s1)C1CC(C)(C)NC(C)(C)C1",
        "output": "751"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCN1CC[C@@H](N)C1.CS(=O)(=O)OCCc1cccc(F)c1.Cl.Cl.O=C([O-])[O-].[K+].[K+]>>CCN1CC[C@@H](NCCc2cccc(F)c2)C1",
        "output": "559"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COc1cccc(-c2noc3cc(F)ccc23)c1.ClCCl>>Oc1cccc(-c2noc3cc(F)ccc23)c1",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CO.COc1ccccc1NC1CCN(C(=O)OC(C)(C)C)CC1.Cl>>COc1ccccc1NC1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)c1ccc(N)c(Br)c1.CCOC(C)=O.COC(=O)c1cc(C)nc(Cl)n1>>COC(=O)c1cc(C)nc(Nc2ccc(C(C)C)cc2Br)n1",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)O.CCN=C=NCCCN(C)C.CN1CCOCC1.Cl.ClCCl.NCCC[C@H](CO)NS(=O)(=O)c1ccc(F)cc1Cl.O=c1c2ccccc2nnn1O>>CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)NCCC[C@H](CO)NS(=O)(=O)c1ccc(F)cc1Cl",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCOCC.CN(C)C=O.Cc1ccc(CN2C(=O)NC(CCO)C2=O)cc1.Cl.O.[Cl-].[Na+].c1c[nH]cn1>>Cc1ccc(CN2C(=O)NC(CCO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)C2=O)cc1",
        "output": "602"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cl.Cl[Fe](Cl)Cl.N#C[Cu].O.O=C(c1ccc(Br)cc1)C1CC1>>N#Cc1ccc(C(=O)C2CC2)cc1",
        "output": "531"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN1CC(NC(=O)OC(C)(C)C)=NC(C)(c2cc(N)ccc2F)C1=O.Cl.ClCCCl.ClCCl.O=C(O)c1ccc(Br)cn1.On1nnc2cccnc21>>CN1CC(NC(=O)OC(C)(C)C)=NC(C)(c2cc(NC(=O)c3ccc(Br)cn3)ccc2F)C1=O",
        "output": "985"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)c1nc(CO)n(Cc2ccccc2[N+](=O)[O-])c1Sc1cc(Cl)cc(Cl)c1.CCOC(C)=O.[H][H].[Pt]>>CC(C)c1nc(CO)n(Cc2ccccc2N)c1Sc1cc(Cl)cc(Cl)c1",
        "output": "588"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)CCNC(=O)c1ccc(CCc2cc(-c3ccc(Cl)c(Cl)c3)ccc2O)cc1.CCN(CC)CC.ClCCl.OB(O)c1ccc(OC(F)(F)F)cc1.[Cu+2]>>CC(C)(C)OC(=O)CCNC(=O)c1ccc(CCc2cc(-c3ccc(Cl)c(Cl)c3)ccc2Oc2ccc(OC(F)(F)F)cc2)cc1",
        "output": "920"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)c1nc(C(=O)N2CCSCC2)sc1-c1ccc(C(O)(C(F)(F)F)C(F)(F)F)c(Cl)c1Cl.Cl>>O=C(O)c1nc(C(=O)N2CCSCC2)sc1-c1ccc(C(O)(C(F)(F)F)C(F)(F)F)c(Cl)c1Cl",
        "output": "569"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C=Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1.[Na+].[OH-]>>O=C(C=Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1ccccc1Oc1ccc2c(c1)C(=O)NC2=O.O=C(Cl)c1cccc([N+](=O)[O-])c1>>O=C(Nc1ccccc1Oc1ccc2c(c1)C(=O)NC2=O)c1cccc([N+](=O)[O-])c1",
        "output": "11"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCN(CCCC)c1ccc2c(c1)C(CCCC)(CCCC)c1cc(Br)ccc1-2.CO.Cc1ccccc1.Cl[Pd]Cl.O=C([O-])[O-].O=Cc1ccc(B(O)O)s1.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCCCN(CCCC)c1ccc2c(c1)C(CCCC)(CCCC)c1cc(-c3ccc(C=O)s3)ccc1-2",
        "output": "903"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCc1ccc(NC(=O)CBr)c([N+](=O)[O-])c1.CCO.CNC>>CCCCc1ccc(NC(=O)CN(C)C)c([N+](=O)[O-])c1",
        "output": "443"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COCCN1CCc2ccc(N)cc2CC1.CS(=O)(=O)NCCNc1nc(Cl)ncc1Cl>>COCCN1CCc2ccc(Nc3ncc(Cl)c(NCCNS(C)(=O)=O)n3)cc2CC1",
        "output": "808"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCN(C(C)C)C(C)C.O.O=C(OCc1ccccc1)N1CCNCC1.O=C1CN(NCc2ccccc2)C(=O)N1CCCCI>>O=C(OCc1ccccc1)N1CCN(CCCCN2C(=O)CN(NCc3ccccc3)C2=O)CC1",
        "output": "184"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCc1ccc2ncc([N+](=O)[O-])c(O)c2c1.O=P(Cl)(Cl)Cl>>CCc1ccc2ncc([N+](=O)[O-])c(Cl)c2c1",
        "output": "177"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOP(=O)(OCC)C(F)(F)c1cc2cc(C#N)ccc2cc1Br.C[Si](C)(C)Br.ClCCl>>N#Cc1ccc2cc(Br)c(C(F)(F)P(=O)(O)O)cc2c1",
        "output": "535"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cccc2c1C[C@@H](N(C)C)CC2.ClC(Cl)Cl.O=C([O-])O.O=S(=O)(O)Cl.[Na+]>>COc1ccc(S(=O)(=O)Cl)c2c1C[C@@H](N(C)C)CC2",
        "output": "357"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3ccc(Cl)c(C(=O)O)c3)cc12.F[P-](F)(F)(F)(F)F.NC1(c2ccccn2)CC1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3ccc(Cl)c(C(=O)NC4(c5ccccn5)CC4)c3)cc12",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCOC(C)=O.CS(C)=O.O=C([O-])[O-].O=c1[nH]nc(CO)c2ccccc12.[Na+].[Na+]>>O=Cc1n[nH]c(=O)c2ccccc12",
        "output": "573"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.C[Si](C)(C)C#Cc1ccc(C(=O)O)cc1.[K+].[OH-]>>C#Cc1ccc(C(=O)O)cc1",
        "output": "337"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1ncn(CC(O)c2ccccn2)c1-c1ccccc1.[Na+].[OH-]>>O=C(O)c1ncn(CC(O)c2ccccn2)c1-c1ccccc1",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.CCN[C@@H]1C[C@H](C(=O)NCC2(CCCCOC)c3ccccc3Oc3ccccc32)CN(C(=O)OC(C)(C)C)C1>>CCN(C(C)=O)[C@@H]1C[C@H](C(=O)NCC2(CCCCOC)c3ccccc3Oc3ccccc32)CN(C(=O)OC(C)(C)C)C1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.CCOC(C)=O.O=C(Nc1ccc(SC(F)(F)F)cc1)c1cnc(Cl)c(Br)c1.OC[C@H]1CCNC1>>O=C(Nc1ccc(SC(F)(F)F)cc1)c1cnc(N2CC[C@H](CO)C2)c(Br)c1",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(C)=O.CC[C@H](NC(=O)OC(C)(C)C)c1ncc(Cl)cc1C(=O)OC.[BH4-].[Ca+2].[Cl-].[Cl-].[Na+]>>CC[C@H](NC(=O)OC(C)(C)C)c1ncc(Cl)cc1CO",
        "output": "522"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C#N)c1c(Cl)cc([N+](=O)[O-])cc1Cl.CO.O=[Pt]=O>>CC(C)(C#N)c1c(Cl)cc(N)cc1Cl",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1C[C@H]2CC(N(C)Cc3ccccc3)C[C@H]2CC1=O.CO.[OH-].[OH-].[Pd+2]>>CNC1C[C@@H]2CN(C)C(=O)C[C@@H]2C1",
        "output": "84"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)CCC=CC12CCCC(C=O)C2.CO.[BH4-].[Na+].[Na+].[OH-]>>CC1(C)CCC=CC12CCCC(CO)C2",
        "output": "223"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCC.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4ccccc4)c3)c3cc(-c4ccc(N5CCN(C(=O)OC(C)(C)C)CC5)nc4)cnc32)cc1.Cl>>Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4ccccc4)c3)c3cc(-c4ccc(N5CCNCC5)nc4)cnc32)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.COc1cc2c(-c3cc4cccnc4n3S(=O)(=O)c3ccc(C)cc3)c[nH]c2cc1OCc1ccccc1.C[Si](C)(C)I>>COc1cc2c(-c3cc4cccnc4n3S(=O)(=O)c3ccc(C)cc3)c[nH]c2cc1O",
        "output": "23"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(C)n1ncc2ccc(Oc3c(F)cc(C(F)(F)F)cc3Cl)cc21.CO.N>>CC(C(N)=O)n1ncc2ccc(Oc3c(F)cc(C(F)(F)F)cc3Cl)cc21",
        "output": "163"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC.CS(=O)(=O)Nc1ccc(NC(=O)CCl)cc1.c1ccc(CC2CCNCC2)cc1>>CS(=O)(=O)Nc1ccc(NC(=O)CN2CCC(Cc3ccccc3)CC2)cc1",
        "output": "340"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.C[C@@H](OCc1cc(F)cc(-c2cc(N)nn2-c2ccc(F)cc2)c1)C(F)(F)F.Cl.O.O=C1C[C@H](C(=O)O)CN1>>C[C@@H](OCc1cc(F)cc(-c2cc(NC(=O)[C@@H]3CNC(=O)C3)nn2-c2ccc(F)cc2)c1)C(F)(F)F",
        "output": "795"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Oc1cc(OC(C)=O)cc(C(=O)O)c1.O=S(Cl)Cl>>CC(=O)Oc1cc(OC(C)=O)cc(C(=O)Cl)c1",
        "output": "3"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(=O)Cl.ClCCl.Nc1ccc(Nc2ccccc2)cc1.O=C([O-])O.[Na+]>>CCC(=O)Nc1ccc(Nc2ccccc2)cc1",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C=CCOC1(C)CCN(c2c([C@H](OC(C)(C)C)C(=O)OCC)c(C)nc3cc(-c4ncc(Cc5ccccc5O[Si](C)(C)C(C)(C)C)s4)nn23)CC1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>C=CCOC1(C)CCN(c2c([C@H](OC(C)(C)C)C(=O)OCC)c(C)nc3cc(-c4ncc(Cc5ccccc5O)s4)nn23)CC1",
        "output": "754"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COc1cc2c(Oc3ccc(NC(=O)OC(C)(C)C)cc3F)ccnc2cc1OCc1ccccc1.[Pd]>>COc1cc2c(Oc3ccc(NC(=O)OC(C)(C)C)cc3F)ccnc2cc1O",
        "output": "23"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CNC(=O)c1ccccc1Nc1nc(Cl)ncc1Cl.COc1c(N)ccc2c1CCC(=O)CC2>>CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2OC)CCC(=O)CC3)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cc2ccccn2c1N1CCN(C)CC1=O.O.[Li+].[OH-]>>CN1CCN(c2c(C(=O)O)cc3ccccn23)C(=O)C1",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COc1ccc(-n2nnnc2-c2cc(-c3cc(C)c(C4CCN(C(=O)OC(C)(C)C)CC4)s3)cnc2N)c(F)c1F.Cl>>COc1ccc(-n2nnnc2-c2cc(-c3cc(C)c(C4CCNCC4)s3)cnc2N)c(F)c1F",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N.ClCCl.O=C(Cl)C1CC1>>Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(=O)C1CC1",
        "output": "399"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCOC(=O)Oc1ccc(C(=O)O)cc1.ClC(Cl)(Cl)Cl.O=S(Cl)Cl>>CCCCOC(=O)Oc1ccc(C(=O)Cl)cc1",
        "output": "3"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(CC1(O)CCNC1)c1ccc(C(=O)OC(C)(C)C)cc1.ClCCl.N#Cc1ccc(CC=O)cc1.O.[Na+].[Na+].[OH-]>>CN(CC1(O)CCN(CCc2ccc(C#N)cc2)C1)c1ccc(C(=O)OC(C)(C)C)cc1",
        "output": "484"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)CCN(C)c1nc2ccccc2c(NCCN2CCOCC2)c1[N+](=O)[O-].CO.[H][H].[Pd]>>CN(C)CCN(C)c1nc2ccccc2c(NCCN2CCOCC2)c1N",
        "output": "269"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.CC(C)(C)OC(=O)N[C@H]1CCc2ccc(O)cc2NC1=O.OCCN1CCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N[C@H]1CCc2ccc(OCCN3CCCC3)cc2NC1=O",
        "output": "478"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc(C)c2ccsc2c1.Cl.O.c1ccncc1>>Cc1cc(O)cc2sccc12",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.CN1CCCC1=O.OCc1cnc(Cl)c(Cl)c1>>CC(C)(C)OC(=O)N1CCN(c2ncc(CO)cc2Cl)CC1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrC(Br)(Br)Br.C1CCCCC1.C1CCOC1.CC(CO)c1ccc(Cl)s1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(CBr)c1ccc(Cl)s1",
        "output": "378"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)Cl.O=C(O)c1ccc(Br)nc1Br>>OCc1ccc(Br)nc1Br",
        "output": "293"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)NC1CCCNCC1O.CCN(CC)CC.CCOC(C)=O.CO.ClCCl.O=S(=O)(Cl)c1cccnc1>>CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)NC1CCCN(S(=O)(=O)c2cccnc2)CC1O",
        "output": "169"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)CC1(c2ccc(OCc3cccc(-c4ccc(OCC5CCOCC5)cc4Cl)c3)cc2)COC1.CO.O.[Li+].[OH-]>>O=C(O)CC1(c2ccc(OCc3cccc(-c4ccc(OCC5CCOCC5)cc4Cl)c3)cc2)COC1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1ccc(-c2nnco2)cc1.C#CC1(O)CN2CCC1CC2.CCN(CC)CC.CN(C)C=O.Cl[Pd]Cl.[Cu]I.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>OC1(C#Cc2ccc(-c3nnco3)cc2)CN2CCC1CC2",
        "output": "659"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CNCC(O)c1ccccc1.COc1nccc2oc(-c3cnc4ccc(Cl)nn34)cc12>>COc1nccc2oc(-c3cnc4ccc(N(C)CC(O)c5ccccc5)nn34)cc12",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCn1c(C(=O)OCC)c(C)c2ccnc(N(Cc3ccc(F)cc3C)C(=O)OC(C)(C)C)c21.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CCCn1c(CO)c(C)c2ccnc(N(Cc3ccc(F)cc3C)C(=O)OC(C)(C)C)c21",
        "output": "711"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1ccc(-c2nc(=O)[nH][nH]2)cc1>>CC(C)(C)CC1NC(C(=O)Nc2ccc(-c3nc(=O)[nH][nH]3)cc2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F",
        "output": "563"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCO.COC(=O)c1cccc(-c2cc(CN(C(=O)c3ncn(C)n3)C3CCOCC3)ccc2F)c1.O.[BH4-].[Na+]>>Cn1cnc(C(=O)N(Cc2ccc(F)c(-c3cccc(CO)c3)c2)C2CCOCC2)n1",
        "output": "444"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(C2CCNCC2)cn1.CCN(CC)CC.ClCCl>>CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(C2CCN(C(C)=O)CC2)cn1",
        "output": "125"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCCC2(C1)C(=O)N(Cc1ncco1)CC2c1ccc(F)cc1.ClCCl.O=C(O)C(F)(F)F>>O=C1N(Cc2ncco2)CC(c2ccc(F)cc2)C12CCCNC2",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.NC(=O)C[C@H](O)CC(=O)OCc1ccccc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)O[C@@H](CC(N)=O)CC(=O)OCc1ccccc1",
        "output": "193"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(-c2ccccc2C(=O)NC(C)(C)C)cc1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>CC(C)(C)NC(=O)c1ccccc1-c1ccc(CBr)cc1",
        "output": "29"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.NC(=O)CBr.NS(=O)(=O)c1ccccc1O.O=C([O-])[O-].[K+].[K+]>>NC(=O)COc1ccccc1S(N)(=O)=O",
        "output": "778"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.NC1C(=O)N2C(C(=O)O)=C(CSc3nncs3)CS[C@H]12.O=C(Cl)CS(=O)C(F)(F)F.O=C([O-])O.[Na+].[Na+].[OH-]>>O=C(CS(=O)C(F)(F)F)NC1C(=O)N2C(C(=O)O)=C(CSc3nncs3)CS[C@H]12",
        "output": "159"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cccc(-c2cn3ccccc3n2)c1.O=C(O)c1cc2cc(O)ccc2oc1=O>>O=C(Nc1cccc(-c2cn3ccccc3n2)c1)c1cc2cc(O)ccc2oc1=O",
        "output": "799"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.O=C([O-])[O-].O=C1OCCN1CCCl.O=[N+]([O-])c1ncc[nH]1.[K+].[K+]>>O=C1OCCN1CCn1ccnc1[N+](=O)[O-]",
        "output": "611"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1cc(OC)c(OCCNCCOc2cc([N+](=O)[O-])c(C(=O)OC)cc2OC)cc1[N+](=O)[O-].O=C([O-])O.[Na+]>>COC(=O)c1cc(OC)c(OCCN(CCOc2cc([N+](=O)[O-])c(C(=O)OC)cc2OC)C(=O)OC(C)(C)C)cc1[N+](=O)[O-]",
        "output": "694"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)CCc1ccc(CO)cc1.ClCCl.[Mn+4].[O-2].[O-2]>>COC(=O)CCc1ccc(C=O)cc1",
        "output": "179"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccccc1Nc1cccc2ccccc12.[Pd]>>Nc1ccccc1Nc1cccc2ccccc12",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.O=C(Cn1ccc(OCc2ccccc2)cc1=O)c1ccc2c(c1)CCN(C(=O)C(F)(F)F)CC2.[Na+].[OH-]>>O=C(Cn1ccc(OCc2ccccc2)cc1=O)c1ccc2c(c1)CCNCC2",
        "output": "703"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)NCCCC(=O)O.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1CO>>CC(=O)NCCCC(=O)OCN1C(=O)CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc21",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cncc(-c2ncnc(O)c2C#N)c1.O=P(Cl)(Cl)Cl>>COc1cncc(-c2ncnc(Cl)c2C#N)c1",
        "output": "168"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1nc2cc(C(=O)c3ccccc3)ccc2[nH]1.CN(C)C=O.Clc1ccc(CBr)cc1Cl.[H-].[Na+]>>CCCc1nc2cc(C(=O)c3ccccc3)ccc2n1Cc1ccc(Cl)c(Cl)c1",
        "output": "658"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Nc1ccc(CCO)cc1.O=[N+]([O-])c1cc(F)ccc1F>>O=[N+]([O-])c1cc(F)ccc1Nc1ccc(CCO)cc1",
        "output": "609"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1cn(-c2cncn2C)c2ccccc12.C[Si](C)(C)[O-].[K+]>>Cn1cncc1-n1cc(C(=O)O)c2ccccc21",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.N#CCOc1ccc2cc(-c3csc(-c4ccccc4)n3)ccc2c1.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>c1ccc(-c2nc(-c3ccc4cc(OCc5nnn[nH]5)ccc4c3)cs2)cc1",
        "output": "366"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cc(-c2cccc(C(=O)CC(=O)Nc3cc(C(F)(F)F)c(N(C)C)cc3NC(=O)OC(C)(C)C)c2)on1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(-c2cccc(C3=Nc4cc(N(C)C)c(C(F)(F)F)cc4NC(=O)C3)c2)on1",
        "output": "930"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)C1CCN(C(=O)OC(C)(C)C)CC1c1ccc(F)c(F)c1.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+].[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(CO)C(c2ccc(F)c(F)c2)C1",
        "output": "343"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.O.O=C1c2ccccc2-c2ccc(N3C[C@@H]4CN[C@@H]4C3)cc21.[Na+]>>CN1C[C@H]2CN(c3ccc4c(c3)C(=O)c3ccccc3-4)C[C@H]21",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(CC)CC.Nc1ccc(I)c(F)c1.O=[N+]([O-])c1cnc(Cl)nc1Cl>>O=[N+]([O-])c1cnc(Cl)nc1Nc1ccc(I)c(F)c1",
        "output": "161"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "NC1CCc2ccccc21.O=C(O)c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1>>O=C(NC1CCc2ccccc21)c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1",
        "output": "753"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOCC.COc1ccc(S(=O)(=O)N(CCCO[Si](C)(C)C(C)(C)C)C(C(=O)OCc2ccccc2)C2CCCCC2)cc1.ClCCl.FB(F)F>>COc1ccc(S(=O)(=O)N(CCCO)C(C(=O)OCc2ccccc2)C2CCCCC2)cc1",
        "output": "708"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCc1ccc(C(=O)O)cc1.NCCc1ccc(CN2CCCC2)cc1>>CCCCc1ccc(C(=O)NCCc2ccc(CN3CCCC3)cc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccccc1N1CCN(CCCN)CC1.O.O=C1CCc2ccc(C(=O)O)cc2N1.O=c1ccc2ccccc2[nH]1>>COc1ccccc1N1CCN(CCCNC(=O)c2ccc3c(c2)NC(=O)CC3)CC1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCCC.CCOC(=O)c1cc(CCOC)n2cccc(C(F)(F)F)c12.C[C@@H]1CCC[C@](O)(CN)C1>>COCCc1cc(C(=O)NC[C@@]2(O)CCC[C@@H](C)C2)c2c(C(F)(F)F)cccn12",
        "output": "498"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.O.OCCC1CC1>>CS(=O)(=O)OCCC1CC1",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CCCCCCc1cn(C(=O)OC(C)(C)C)c(N)n1.Cc1c(C)c(C)c(S(=O)(=O)NCCN=[N+]=[N-])c(C)c1C>>Cc1c(C)c(C)c(S(=O)(=O)NCCn2cc(CCCCCc3cn(C(=O)OC(C)(C)C)c(N)n3)nn2)c(C)c1C",
        "output": "963"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CN(C(=O)C(F)(F)F)CCc2cc(O)c(Br)cc21.CO.O.[Na+].[OH-]>>CC1CNCCc2cc(O)c(Br)cc21",
        "output": "703"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.ClCCl.Cn1ccc(NC(=O)c2nc(C3CC3)ccc2NC(=O)OC(C)(C)C)n1.O.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>Cn1ccc(NC(=O)c2nc(C3CC3)ccc2N)n1",
        "output": "877"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(COc2cccc(C(=O)O)c2)cc1.Nc1ccccc1S(N)(=O)=O.O=S(Cl)Cl.c1ccccc1.c1ccncc1>>COc1ccc(COc2cccc(C(=O)Nc3ccccc3S(N)(=O)=O)c2)cc1",
        "output": "50"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCCCCCCCCCCSCc1ccc([N+](=O)[O-])cc1.CO.O.[Cl-].[Fe].[NH4+]>>CCCCCCCCCCCCCCCCSCc1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.COC(=O)C=Cc1ccc([N+](=O)[O-])cc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl.Cl.[Zn]>>COC(=O)C=Cc1ccc(N)cc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC1Cc2c(F)cccc2C1O.ClCCl.O=C(O)C(F)(F)F>>NC1Cc2c(F)cccc2C1O",
        "output": "538"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.COC(=O)c1ccc([C@H]2CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC[C@@H]3[C@H]5[C@H](C(C)C)CC[C@]5(N)CC[C@]34C)C2(C)C)cc1.O=P([O-])([O-])[O-].O=S1(=O)CCN(CCCl)CC1.[I-].[K+].[K+].[K+].[K+]>>COC(=O)c1ccc([C@H]2CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC[C@@H]3[C@H]5[C@H](C(C)C)CC[C@]5(NCCN5CCS(=O)(=O)CC5)CC[C@]34C)C2(C)C)cc1",
        "output": "279"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)C1=Cc2cc(C#N)ccc2NC1C(F)(F)F.CCOCC.CO.Cl.O.[Li+].[OH-]>>N#Cc1ccc2c(c1)C=C(C(=O)O)C(C(F)(F)F)N2",
        "output": "122"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CI.CN(C)C=O.Nc1ncccc1C(=O)O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cccnc1N",
        "output": "415"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(O)CN.CCN(CC)CC.ClCCl.O=C(Cl)c1ccncc1>>CC(O)CNC(=O)c1ccncc1",
        "output": "271"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)[O-].CN1CCC(CO)CC1.O=[N+]([O-])c1ccc(F)cc1.[K+]>>CN1CCC(COc2ccc([N+](=O)[O-])cc2)CC1",
        "output": "485"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cccc(C(F)(F)F)c1C(=O)Cl.Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1.O=C1CC(=O)N(c2ccc(C(=O)O)cc2)c2ccc3ccccc3c2N1>>COc1cccc(C(F)(F)F)c1C(=O)Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1",
        "output": "11"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)C(=O)Nc2cc3[nH]c(-c4n[nH]c5ccc(C(=O)O)cc45)nc3cc21.CCN.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O>>CCNC(=O)c1ccc2[nH]nc(-c3nc4cc5c(cc4[nH]3)NC(=O)C5(C)C)c2c1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1ccc2cc[nH]c2c1.[BH3-]C#N.[Na+]>>Brc1ccc2c(c1)NCC2",
        "output": "672"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "NCCCNc1ccc2ccccc2n1.O=CC(c1ccccc1)c1ccccc1.[BH3-]C#N.[Na+]>>c1ccc(C(CNCCCNc2ccc3ccccc3n2)c2ccccc2)cc1",
        "output": "426"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC#CC(=O)NCCOc1cccc(Nc2cc(-c3cc(F)cc(-n4ncc5c6c(sc5c4=O)CCCC6)c3COC(C)=O)cn(C)c2=O)n1.CC(C)O.O.O.[Li]O>>CC#CC(=O)NCCOc1cccc(Nc2cc(-c3cc(F)cc(-n4ncc5c6c(sc5c4=O)CCCC6)c3CO)cn(C)c2=O)n1",
        "output": "497"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)c1cc(C2=CCC(c3ccc(O)cc3)CC2)ccc1O.CC(C)O.[Ni]>>CC(C)(C)c1cc(C2CCC(c3ccc(O)cc3)CC2)ccc1O",
        "output": "249"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNCC1.CCO.O=C1Cc2ccc(NC(=O)c3ccccc3)cc2N1.O=Cc1ccc[nH]1>>O=C1Nc2cc(NC(=O)c3ccccc3)ccc2C1=Cc1ccc[nH]1",
        "output": "440"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccccc1.CC(C)C[C@@H](C(=O)O)[C@H](C/C=C/c1ccccc1)C(=O)OC(C)(C)C.CCN(CC)CC.CCOC(C)=O>>CC(C)C[C@@H](C(=O)OCc1ccccc1)[C@H](C/C=C/c1ccccc1)C(=O)OC(C)(C)C",
        "output": "403"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)C(C)c1ccc2c(c1)Cc1cccnc1S2.O.[Na+].[OH-]>>CC(C(=O)O)c1ccc2c(c1)Cc1cccnc1S2",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOP(=O)(CCCCCCOc1ccc(CCc2cnc3c(N)nc4cc(C)ccc4c3c2)c(C)c1)OCC.O=C(O)C(F)(F)F>>Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCCCCCCP(=O)(O)O)cc3C)cc12",
        "output": "535"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.O=C([O-])O.O=Cc1ccc(C(=O)O)cc1[N+](=O)[O-].[Na+].c1ccc2c(c1)CCN2>>O=Cc1ccc(C(=O)N2CCc3ccccc32)cc1[N+](=O)[O-]",
        "output": "873"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O.O=C1CCCCc2ccccc21.O=S(=O)(O)O.O=[N+]([O-])O>>O=C1CCCCc2c1cccc2[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COc1nc(Cl)nc(C)c1COc1cc(C(C)C)ccc1C.Cc1cccc(C)c1B(O)O.O=C([O-])[O-].[Na+].[Na+]>>COc1nc(-c2c(C)cccc2C)nc(C)c1COc1cc(C(C)C)ccc1C",
        "output": "874"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.Cc1ccccc1.Nc1ccc(Oc2ncnc3oc(-c4ccccc4)cc23)cc1.O=C=Nc1ccc(F)cc1>>O=C(Nc1ccc(F)cc1)Nc1ccc(Oc2ncnc3oc(-c4ccccc4)cc23)cc1",
        "output": "912"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)C(=O)Cl.Cc1ccccc1N.ClCCl.O.O=C([O-])[O-].[Na+].[Na+]>>Cc1ccccc1NC(=O)C(C)(C)C",
        "output": "9"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(=O)(=O)c1ncc2c(n1)N(c1ccccc1)C(=O)N(c1c(Cl)cccc1Cl)C2.ClCCl.NC1CCCCC1>>O=C1N(c2c(Cl)cccc2Cl)Cc2cnc(NC3CCCCC3)nc2N1c1ccccc1",
        "output": "629"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.OCCCc1ccc(-c2ccccc2F)nc1>>Fc1ccccc1-c1ccc(CCCBr)cn1",
        "output": "224"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCO.N#Cc1ccc(Cl)c([N+](=O)[O-])c1.NC[C@@H]1CCN(C(=O)C2CC2)C1>>N#Cc1ccc(NC[C@@H]2CCN(C(=O)C3CC3)C2)c([N+](=O)[O-])c1",
        "output": "304"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCc1noc(-c2ccc(C=O)cc2)n1.COc1ccccc1CN>>CCCCCCCCc1noc(-c2ccc(CNCc3ccccc3OC)cc2)n1",
        "output": "683"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cc1ccc2c(N3CCN(CCc4cccc([N+](=O)[O-])c4)CC3)c(F)ccc2n1.O.[Cl-].[Fe].[NH4+]>>Cc1ccc2c(N3CCN(CCc4cccc(N)c4)CC3)c(F)ccc2n1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)c1ccc2c(ccn2-c2ccc(F)cc2)c1.Cl.O.O.[Li]O>>O=C(O)c1ccc2c(ccn2-c2ccc(F)cc2)c1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COCCC1(N)CC1.COc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)O)cn2)c1O>>COCCC1(NC(=O)c2ccc(-n3ncc(-c4ccc(C#N)cc4OC)c3O)nc2)CC1",
        "output": "674"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C1CCC2(CC1)OCCO2.CO.[Li+].[OH-]>>O=C(O)C1CCC2(CC1)OCCO2",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)c1ccc(C(F)F)o1.[Na+].[OH-]>>O=C(O)c1ccc(C(F)F)o1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.COc1ccc(Nc2ccc(CO)c(F)n2)cn1.O=C([O-])[O-].[K+].[K+]>>COc1ccc(Nc2ccc(C=O)c(F)n2)cn1",
        "output": "520"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(Cl)c(Oc2c(NS(=O)(=O)c3ccc(C(F)(F)F)cc3)cc(C(=O)O)cc2OCCO)c1.Nc1ccccc1>>COc1ccc(Cl)c(Oc2c(NS(=O)(=O)c3ccc(C(F)(F)F)cc3)cc(C(=O)Nc3ccccc3)cc2OCCO)c1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(CC2(C)CC2)c2nc(C)nn12.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(CC2(C)CC2)c2nc(C)nn12",
        "output": "979"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CCOC(=O)c1c(CCCC(=O)OC)ccc2ccccc12.CC(C)O.[Li+].[OH-]>>C=CCOC(=O)c1c(CCCC(=O)O)ccc2ccccc12",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cc1ccc(Cn2c(NC3CCNCC3)nc3ccccc32)o1.c1ccc(OCC2CO2)cc1>>Cc1ccc(Cn2c(NC3CCN(CC(O)COc4ccccc4)CC3)nc3ccccc32)o1",
        "output": "76"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=Cc1cccc2[nH]ccc12.[Cl-].[H-].[NH4+].[Na+]>>O=Cc1cccc2c1ccn2Cc1ccccc1",
        "output": "528"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)[O-].CC(=O)[O-].COc1cc(B(O)O)ccc1O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C.Nc1ccccc1I.O.O=C([O-])[O-].[K+].[K+].[Pd+2]>>COc1cc(-c2ccccc2N)ccc1O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C",
        "output": "855"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1cc2cc(NC(C)=O)ccc2o1.[Na+].[OH-]>>CC(=O)Nc1ccc2oc(C(=O)O)cc2c1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cc(N)cc(CO)c1.ClCCl>>Cc1cc(CO)cc(NC(=O)OC(C)(C)C)c1",
        "output": "735"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOCC.CN(C)C=O.Oc1ccc2cc(Br)ccc2c1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1ccc2cc(Br)ccc2c1",
        "output": "746"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(O)CCl.CN(C)C=O.O=C1NC(=O)C(=Cc2cnn3c(NC4CCNCC4)cc(Nc4cccc(Cl)c4)nc23)N1.[I-].[K+]>>CC(O)CN1CCC(Nc2cc(Nc3cccc(Cl)c3)nc3c(C=C4NC(=O)NC4=O)cnn23)CC1",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.CC(C)(C)OC(=O)C(C)(C)Sc1ccc2c(c1)CCC(N)C2.CCN(C(C)C)C(C)C.ClCCl>>CC(=O)NC1CCc2cc(SC(C)(C)C(=O)OC(C)(C)C)ccc2C1",
        "output": "45"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC[C@@H]1CCCN1.CS(=O)(=O)Cl.Cl>>COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC[C@@H]1CCCN1S(C)(=O)=O",
        "output": "584"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OCC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)[C@@H](Nc3nc(C)cs3)[C@H]2SC1.COc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](Nc3nc(C)cs3)[C@H]2SC1",
        "output": "228"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.COCCCc1cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@]2(O)c2ccnc(OCc3ccccc3)c2)C2CC2)cc(OCCOC)c1.[H-].[Na+]>>COCCCc1cc(CN(C(=O)[C@H]2CN(C(=O)OC(C)(C)C)CC[C@]2(OC)c2ccnc(OCc3ccccc3)c2)C2CC2)cc(OCCOC)c1",
        "output": "140"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1ccc(OC(F)F)cn1.O=C(O)c1cccc(S(=O)(=O)N2CCCCC2)c1>>O=C(Nc1ccc(OC(F)F)cn1)c1cccc(S(=O)(=O)N2CCCCC2)c1",
        "output": "744"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(NC2CC2)CC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(Cl)=[N+](C)C.Cc1ncoc1-c1ccc(C(=O)O)cn1.F[P-](F)(F)(F)(F)F.O>>Cc1ncoc1-c1ccc(C(=O)N(C2CC2)C2CCN(C(=O)OC(C)(C)C)CC2)cn1",
        "output": "256"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(F)cc1C(C)(C)CCO.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>COc1ccc(F)cc1C(C)(C)CC=O",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=S)C(C(=O)O)C(C)C.C[C@H](N)C(=O)C1(N)N=C(c2ccccc2)c2ccccc2N(C)C1=O>>CC(=S)C(C(=O)N[C@@H](C)C(=O)C1(N)N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(C)C",
        "output": "645"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)CC(C)C.CCOC(=O)CCCCl.O=C([O-])O.[I-].[K+].[Na+].c1ccc(C(OC2CCNCC2)c2ccccc2)cc1>>CCOC(=O)CCCN1CCC(OC(c2ccccc2)c2ccccc2)CC1",
        "output": "138"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)[Si](OCc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCC[C@@H]5C)n4c3)c3ccccc32)cc1OCCO)(C(C)C)C(C)C.CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.ClCCl>>CC(C)[Si](OCc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(N5CCCC[C@@H]5C)n4c3)c3ccccc32)cc1OCCOS(C)(=O)=O)(C(C)C)C(C)C",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CCO.O=[N+]([O-])c1cc(Cc2ccccc2)cc(Br)c1O.[Pt]>>Nc1cc(Cc2ccccc2)cc(Br)c1O",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCCCc1ccc(CN)cc1.CCOC(C)=O.CO.COC(=O)Cc1cccc(C=O)c1.Cl.[BH3-]C#N.[Na+].[Na+].[OH-]>>CCCCc1ccc(CNCc2cccc(CC(=O)OC)c2)cc1",
        "output": "683"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(Nc2ncc(-c3ccc(OC(F)F)cc3)cn2)cc1NC(=O)N1CCNC2(CC2)C1.ClCCl.O=CCO.O=S(=O)([O-])[O-].[Na+].[Na+]>>Cc1ccc(Nc2ncc(-c3ccc(OC(F)F)cc3)cn2)cc1NC(=O)N1CCN(CCO)C2(CC2)C1",
        "output": "484"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].CCO.COc1c(C)cc(F)cc1C(C)=O.N.[BH4-].[Na+].[Ti+4]>>COc1c(C)cc(F)cc1C(C)N",
        "output": "552"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N[C@H]1CCN(CC2Cn3c(=O)ccc4ncc(Cl)c2c43)C[C@H]1O.O=C1CSc2ccc(C(=O)O)nc2N1>>O=C1CSc2ccc(C(=O)N[C@H]3CCN(CC4Cn5c(=O)ccc6ncc(Cl)c4c65)C[C@H]3O)nc2N1",
        "output": "137"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)N.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O=C(O)c1ccc(OCc2c(-c3ccccn3)noc2CO)nc1>>CC(C)NC(=O)c1ccc(OCc2c(-c3ccccn3)noc2CO)nc1",
        "output": "674"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)COc1ccc(Br)cc1.CO.N>>NC(=O)COc1ccc(Br)cc1",
        "output": "163"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)c1cnc2c(cnn2CC)c1N(C)C1CCOCC1.[Na+].[OH-]>>CCn1ncc2c(N(C)C3CCOCC3)c(C(=O)O)cnc21",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1cncc2ccccc12.CC(C)(C)[O-].O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.OCCC1CCNCC1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>OCCC1CCN(c2cncc3ccccc23)CC1",
        "output": "597"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.N#Cc1cnc2c(Br)cc(NCc3cn(C4CCNCC4)nn3)cc2c1Nc1ccc(F)c(Cl)c1.[Na+]>>CN1CCC(n2cc(CNc3cc(Br)c4ncc(C#N)c(Nc5ccc(F)c(Cl)c5)c4c3)nn2)CC1",
        "output": "217"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=P(Cl)(Cl)Cl.O=[N+]([O-])c1cnc(-c2ccccn2)nc1O>>O=[N+]([O-])c1cnc(-c2ccccn2)nc1Cl",
        "output": "25"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.O.O=[Cr](=O)(O)O.O=c1[nH]c2ccccc2n1C1CCN(CCCC(O)c2ccc(F)cc2)CC1.[Na+].[OH-]>>O=C(CCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1",
        "output": "32"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(CCO)CC(C)(C)C.CCCC[O-].CCCC[O-].CCCC[O-].CCCC[O-].COC(=O)C1CC=CCC1.[Ti+4]>>CC(CCOC(=O)C1CC=CCC1)CC(C)(C)C",
        "output": "289"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.FB(F)F.Fc1ccccc1>>CC(=O)c1ccc(F)cc1",
        "output": "31"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1cccc(-c2ncccn2)c1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccccc1.O.O.[C-]#N.[I-].[Na+]>>N#CCc1cccc(-c2ncccn2)c1",
        "output": "39"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=O.CC(C)(C)OC(=O)N[C@H]1CCNC1.CO.O.[BH4-].[Na+]>>CN1CC[C@H](NC(=O)OC(C)(C)C)C1",
        "output": "217"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CN(C)C=O.Clc1ccc2cc(CBr)ccc2n1.O=C1CN(C(=O)OCc2ccccc2)CCN1.[H-].[Na+]>>O=C1CN(C(=O)OCc2ccccc2)CCN1Cc1ccc2nc(Cl)ccc2c1",
        "output": "774"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOCC.COc1ccc(C(=O)O)c(C)c1.O=S(Cl)Cl>>CCOC(=O)c1ccc(OC)cc1C",
        "output": "47"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=C(O)c1ccc2nc[nH]c(=O)c2c1.O=S(Cl)Cl>>COC(=O)c1ccc2nc[nH]c(=O)c2c1",
        "output": "33"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(CO)c1cc(NC(=O)C(C)(C)S(=O)(=O)C2CCOCC2)on1.ClCCl>>CC(C)(C=O)c1cc(NC(=O)C(C)(C)S(=O)(=O)C2CCOCC2)on1",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN.Cc1ccc(S(=O)(=O)OCC2Cc3cc(Cl)cc(-c4cc(Cl)ccc4Cl)c3O2)cc1>>CNCC1Cc2cc(Cl)cc(-c3cc(Cl)ccc3Cl)c2O1",
        "output": "853"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.COc1cc(C(=O)O)ccc1-c1cc(F)c2cc(O)ccc2n1.COc1cc(C(=O)O)ccc1-c1ccc2cc(O)ccc2n1.ClCCl.O>>O=C(O)c1ccc(-c2ccc3cc(O)ccc3n2)c(O)c1",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.Cc1cc(Cl)nn2c(-c3ccnc4c3ccn4S(=O)(=O)c3ccccc3)c(-c3ccc(F)cc3)nc12.O.[Na+].[OH-]>>Cc1cc(Cl)nn2c(-c3ccnc4[nH]ccc34)c(-c3ccc(F)cc3)nc12",
        "output": "831"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1ccc([N+](=O)[O-])cc1Cl.CCO.ClCCl.O.[Cl-].[Fe].[NH4+]>>CC(=O)c1ccc(N)cc1Cl",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1n[nH]c(=O)c(-c2c(F)ccc(Cl)c2F)c1-c1ccc(Cl)cc1.O=P(Cl)(Cl)Cl>>Cc1nnc(Cl)c(-c2c(F)ccc(Cl)c2F)c1-c1ccc(Cl)cc1",
        "output": "537"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C=CC(=O)O.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.NC(O)CC1(Cc2ccccc2)C=CC(Cc2ccccc2)=CC1.c1cc(N2CCCC2)ccn1>>C=CC(=O)OC(N)CC1(Cc2ccccc2)C=CC(Cc2ccccc2)=CC1",
        "output": "174"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cl.O=C(O)c1nccc(Cl)c1Br>>COC(=O)c1nccc(Cl)c1Br",
        "output": "331"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cn(C(Cc2cnco2)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1C#N.Nc1ccc2nccn2c1>>COc1cn(C(Cc2cnco2)C(=O)Nc2ccc3nccn3c2)c(=O)cc1-c1cc(Cl)ccc1C#N",
        "output": "724"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CN(C)S(=O)(=O)c1ccc(N)cc1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Cl>>COc1ccc2nc(Nc3ccc(S(=O)(=O)N(C)C)cc3)c3n[nH]cc3c2c1",
        "output": "998"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.C[Si](C)(C)Cl.Cc1ccc(S(=O)(=O)O)cc1.O=C(O)C1(c2ccccc2)CCNCC1>>COC(=O)C1(c2ccccc2)CCNCC1",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCOC(C)=O.CN(C)c1ccncc1.CS(=O)(=O)NCc1ccc(NC(=O)Oc2ccccc2)cc1F.Cc1cccc(-c2nc(C(F)(F)F)ccc2CN)c1>>Cc1cccc(-c2nc(C(F)(F)F)ccc2CNC(=O)Nc2ccc(CNS(C)(=O)=O)c(F)c2)c1",
        "output": "488"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cccc(C(=O)Cl)c1.NC1CCCc2c1[nH]c1ccc(Br)cc21>>Cc1cccc(C(=O)NC2CCCc3c2[nH]c2ccc(Br)cc32)c1",
        "output": "271"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCc1ccc(Br)cc1C1C(=O)C(C)(C)C(=O)C(C)(C)C1=O.Cc1nc(Cl)ccc1B(O)O.ClCCl.O.[Cs+].[F-]>>CCc1ccc(-c2ccc(Cl)nc2C)cc1C1C(=O)C(C)(C)C(=O)C(C)(C)C1=O",
        "output": "899"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Clc1ccc(N2CCNCC2)cc1Cl.O=C(O)c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1>>O=C(c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1)N1CCN(c2ccc(Cl)c(Cl)c2)CC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccccc1.C#Cn1c2c(c3cc(C)ccc31)CN(C)CC2.CCCC[N+](CCCC)(CCCC)CCCC.O.[F-]>>Cc1ccc2c(c1)c1c(n2C#Cc2ccccc2)CCN(C)C1",
        "output": "659"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COc1cc([C@H]2CCN(CCO)C[C@@H]2O)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1.ClCCl.O=C(Cl)c1ccc(Br)cc1>>COc1cc([C@H]2CCN(CCOC(=O)c3ccc(Br)cc3)C[C@@H]2O)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1",
        "output": "51"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.CC(=O)Cl.CCCCC12CCC(=O)C(Br)=C1c1cc(F)c(N)c(Cl)c1C2.CCO.ClCCl.[Na+].[OH-].c1ccncc1.c1ccncc1>>CCCCC12CCC(=O)C(Br)=C1c1cc(F)c(NC(C)=O)c(Cl)c1C2",
        "output": "9"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NC1CCNCC1.CCO.O=[N+]([O-])c1c(F)cccc1F>>CC(C)(C)OC(=O)NC1CCN(c2cccc(F)c2[N+](=O)[O-])CC1",
        "output": "26"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)/N=N/C(=O)OCC.CS(=O)(=O)CCCO.Cc1c(O)cn2ncnc(Oc3ccccc3)c12.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1c(OCCCS(C)(=O)=O)cn2ncnc(Oc3ccccc3)c12",
        "output": "547"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COCCBr.Cc1nc(OCC(=O)N(C)C2CCNCC2)nc(C)c1NC(=O)OC(C)(C)C>>COCCN1CCC(N(C)C(=O)COc2nc(C)c(NC(=O)OC(C)(C)C)c(C)n2)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@@H]1c1cc(-c2ccccc2)on1.ClCCl.O=C(O)C(F)(F)F>>c1ccc(-c2cc([C@H]3CCCN3)no2)cc1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CS(C)=O.O.O=C([O-])[O-].OC1CCC(Nc2ccc3ncc(-c4ccnc(Cl)c4)n3c2)CC1.[Cs+].[Cs+]>>CCOc1cc(-c2cnc3ccc(NC4CCC(O)CC4)cn23)ccn1",
        "output": "433"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.C[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.ClCCl.Nc1ccc(F)c2c1NCCO2.On1nnc2cccnc21>>C[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc(F)c2c1NCCO2",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C(=O)O)CCC1.CCN(C(C)C)C(C)C.CCOc1ccc(OC2CN(c3ccc([C@H](C)N)cc3)C2)cc1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F>>CCOc1ccc(OC2CN(c3ccc([C@H](C)NC(=O)C4(C)CCC4)cc3)C2)cc1",
        "output": "599"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)CC(NC(=O)C(C)(C)C)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(C#N)cc3Cl)nc2O1.CCO.Cl.NO.O=C([O-])O.[Na+]>>CC1(C)CC(NC(=O)C(C)(C)C)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(C(=N)NO)cc3Cl)nc2O1",
        "output": "854"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)Cc1ccncc1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.[Na+]>>CCOC(=O)Cc1cc[n+]([O-])cc1",
        "output": "262"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cccc(C=O)c1.FC(F)(F)c1nnc2ccc(N3CCCNCC3)nn12>>COc1cccc(CN2CCCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)c1",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(CC2NC(=O)n3c2nc2ccccc23)c(F)c1F.N[C@H]1CC[C@H](O)CC1.O=C(O)C(F)(F)F>>COc1ccc(CC(NC(=O)N[C@@H]2CC[C@@H](O)CC2)c2nc3ccccc3[nH]2)c(F)c1F",
        "output": "999"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCOC(=O)c1cn(-c2ccc3c(c2)n(C2CC2)c(=O)n3C)c(=O)n([C@@H]2CCc3c2cccc3C(F)(F)F)c1=O>>Cn1c(=O)n(C2CC2)c2cc(-n3cc(C(=O)O)c(=O)n([C@@H]4CCc5c4cccc5C(F)(F)F)c3=O)ccc21",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.N#Cc1ccccc1F.O=C([O-])[O-].[K+].[K+].c1cn[nH]c1>>N#Cc1ccccc1-n1cccn1",
        "output": "751"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(F)cc(CC(=O)O)c1.ClCCl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>O=C(O)Cc1cc(F)cc(CBr)c1",
        "output": "29"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)c1nc(N(C)S(=O)(=O)CCCCNC(=O)c2cc(F)ccc2CNC(=O)OC(C)(C)C)c2cccnc2c1OS(=O)(=O)c1ccc(C)cc1.Cl.O.[Li+].[OH-]>>Cc1ccc(S(=O)(=O)Oc2c(C(=O)O)nc(N(C)S(=O)(=O)CCCCNC(=O)c3cc(F)ccc3CNC(=O)OC(C)(C)C)c3cccnc23)cc1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC1(O)CNC1.CCN(CC)CC.COc1ccc(-c2nnc(C(=O)N3CC(Oc4ccc(C=O)c(C)c4)C3)o2)cc1.Cl.ClCCl.[Na+]>>COc1ccc(-c2nnc(C(=O)N3CC(Oc4ccc(CN5CC(C)(O)C5)c(C)c4)C3)o2)cc1",
        "output": "567"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(=O)N(C)C.Nc1ccc(NNC=O)cc1.O=[N+]([O-])c1cc(S(=O)(=O)Cl)ccc1Cl.[Cl-].c1ccncc1>>O=CNNc1ccc(NS(=O)(=O)c2ccc(Cl)c([N+](=O)[O-])c2)cc1",
        "output": "68"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.ClCCl.Oc1ccc2nc(Cl)oc2c1>>CC(=O)Oc1ccc2nc(Cl)oc2c1",
        "output": "46"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC2=NCCCN2CC1.C1CCOC1.COCCCS(N)(=O)=O.O=C(O)CCc1cc(OCC2CC2)nn1Cc1ccc(C(F)(F)F)cc1Cl>>COCCCS(=O)(=O)NC(=O)CCc1cc(OCC2CC2)nn1Cc1ccc(C(F)(F)F)cc1Cl",
        "output": "644"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1C(F)(F)F)C(=O)O.CCN(C(C)C)C(C)C.ClCCl.Cn1nccc1-c1cc(C(=O)O)sc1Cl.F[P-](F)(F)(F)(F)F.N[C@@H](CC1CCCCC1)CN1C(=O)c2ccccc2C1=O>>Cn1nccc1-c1cc(C(=O)N[C@@H](CC2CCCCC2)CN2C(=O)c3ccccc3C2=O)sc1Cl",
        "output": "736"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=C1Cc2ccccc2N1>>CC(C)(C)c1cc(C=C2C(=O)Nc3ccccc32)cc(C(C)(C)C)c1O",
        "output": "439"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)OC(C)C.CS(=O)(=O)Cl.OCC(CCOc1ccc(Br)cc1)c1ccc(Cl)cc1Cl.c1ccncc1>>CS(=O)(=O)OCC(CCOc1ccc(Br)cc1)c1ccc(Cl)cc1Cl",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(CCCO)[N+](=O)[O-].CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O>>CC(C)(CCCOS(C)(=O)=O)[N+](=O)[O-]",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cccc(C)c1NC(=O)CCl.Cl.Cl.NC1CCN(CCCC(=O)c2ccccc2)CC1>>Cc1cccc(C)c1NC(=O)CNC1CCN(CCCC(=O)c2ccccc2)CC1",
        "output": "330"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)I.CN(C)C=O.COc1cc(C=O)cc(F)c1O.O=C([O-])[O-].[K+].[K+]>>COc1cc(C=O)cc(F)c1OC(C)C",
        "output": "318"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.O.OB(O)c1ccc2[nH]ncc2c1>>CC(C)(C)OC(=O)n1ncc2cc(B(O)O)ccc21",
        "output": "841"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1ccc(C=O)cc1.CCNC(=O)Nc1cc2cc(N)cc(C)c2cn1>>CCNC(=O)Nc1cc2cc(NCc3ccc(NC(C)=O)cc3)cc(C)c2cn1",
        "output": "359"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COc1ncnc(N)c1C(F)(F)F.Cl>>Nc1ncnc(O)c1C(F)(F)F",
        "output": "408"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCCCCC(=O)CCC(C#N)[C@@H]1CC[C@@H](OC)CC1.CO.O.[BH4-].[Na+]>>CCCCCCC(O)CCC(C#N)[C@@H]1CC[C@@H](OC)CC1",
        "output": "91"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCNCCCC.CCN(CC)CC.COC1CCCC1.Cl.O=C(Cl)OCCl>>CCCCN(CCCC)C(=O)OCCl",
        "output": "219"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)CC(=O)O.O=C(Nc1ccc(N2CCC3CNCC32)cc1)c1ccc(COC2CCC2)cc1>>CN(C)CC(=O)N1CC2CCN(c3ccc(NC(=O)c4ccc(COC5CCC5)cc4)cc3)C2C1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCCC(CN)C1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccccc1C(=O)O.F[P-](F)(F)(F)(F)F>>COc1ccccc1C(=O)NCC1CCCN(C(=O)OC(C)(C)C)C1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(OCC)c1cc(-c2ccc(N)cc2)nn1C.ClCCl.O=C(Cl)OCc1ccccc1.c1ccncc1>>CCOC(OCC)c1cc(-c2ccc(NC(=O)OCc3ccccc3)cc2)nn1C",
        "output": "509"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.CCN(C(C)C)C(C)C.Cl.ClCCl.NCCCOc1ccc(C(=O)Nc2ccc(-c3ccccc3)cc2)cc1NC(=O)C1(N2CCOCC2)CC1.c1ccncc1>>CC(=O)NCCCOc1ccc(C(=O)Nc2ccc(-c3ccccc3)cc2)cc1NC(=O)C1(N2CCOCC2)CC1",
        "output": "339"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CCOCC.Cl.Cl[Sn]Cl.N#Cc1cc(F)cc(-c2cc([N+](=O)[O-])c3c(c2)C2(CCCCC2)C(=O)N3)c1.O.O>>N#Cc1cc(F)cc(-c2cc(N)c3c(c2)C2(CCCCC2)C(=O)N3)c1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)c1cc2c(C(=O)O)cccn2n1.CCOC(C)=O.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.NCC12CC3CC(CC(C3)C1)C2>>CCOC(=O)c1cc2c(C(=O)NCC34CC5CC(CC(C5)C3)C4)cccn2n1",
        "output": "674"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(C)=O.O.O=Cc1c2ccccc2c(CO)c2ccccc12>>O=Cc1c2ccccc2c(C=O)c2ccccc12",
        "output": "179"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Cc1nn(-c2ccc(O)cc2)c2c1CCC1CCCCC21.ClCCCN1CCCC1.O=C([O-])O.[H-].[I-].[Na+].[Na+].[Na+]>>Cc1nn(-c2ccc(OCCCN3CCCC3)cc2)c2c1CCC1CCCCC21",
        "output": "74"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOCC.COCCOCOc1cc(C)c(Br)cc1C(C)(C)C.O=C=O.[Li]CCCC.[Na+].[OH-]>>COCCOCOc1cc(C)c(C(=O)O)cc1C(C)(C)C",
        "output": "654"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.COc1cc(-c2ncc(Br)cc2N)c(F)cn1.Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Cl.O=C([O-])[O-].[H-].[Na+].[Na+].[Na+]>>COc1cc(-c2ncc(Br)cc2Nc2c(C)c(-c3ccccn3)nc3cc(F)cc(F)c23)c(F)cn1",
        "output": "859"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(N)cc1-c1c(Cl)cnn1C.O=C=Nc1cccc(Cl)c1>>COc1ccc(NC(=O)Nc2cccc(Cl)c2)cc1-c1c(Cl)cnn1C",
        "output": "804"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)CC(=O)NC(CCCc2ccccc2)CCCc2ccccc2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(CC(=O)N1CCNCC1)NC(CCCc1ccccc1)CCCc1ccccc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)Oc1ccc(Cl)c(C(=O)O)c1Cl>>CC(C)Oc1ccc(Cl)c(CO)c1Cl",
        "output": "72"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cc1ccc2c(c1)c1c(n2CC(N=[N+]=[N-])c2ccncc2)CCN(C)C1.O.[Cl-].[NH4+].[Zn]>>Cc1ccc2c(c1)c1c(n2CC(N)c2ccncc2)CCN(C)C1",
        "output": "89"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.CCOC(=O)C1c2ccc(OC)cc2CCN1C(=O)OC(C)(C)C.Cl.O.[Li+].[OH-]>>COc1ccc2c(c1)CCN(C(=O)OC(C)(C)C)C2C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.O.O=C1CCC(=O)N1Br.O=Cc1cccn1-c1c(Cl)cccc1Cl>>O=Cc1cc(Br)cn1-c1c(Cl)cccc1Cl",
        "output": "796"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "NCCC1CC1.O=C(O)c1cnc(N2CCN(C(=O)c3ccccc3C(F)(F)F)CC2)s1>>O=C(NCCC1CC1)c1cnc(N2CCN(C(=O)c3ccccc3C(F)(F)F)CC2)s1",
        "output": "534"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCC(CC(=O)Nc1cc(C(=O)OC)ccc1C(C)(C)C)c1ccc(OCC(=O)OC(C)(C)C)cc1OC.COc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>CCCCCC(CC(=O)Nc1cc(C(=O)OC)ccc1C(C)(C)C)c1ccc(OCC(=O)O)cc1OC",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.Cl.Nc1ccc2[nH]c(=S)oc2c1.O=C(O)CN1CCC(Cc2ccccc2)CC1>>O=C(CN1CCC(Cc2ccccc2)CC1)Nc1ccc2[nH]c(=S)oc2c1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.Cc1ccc2cc(F)c(OC(C)C)cc2n1.O.O=[Se]=O>>CC(C)Oc1cc2nc(C=O)ccc2cc1F",
        "output": "619"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=Cc1ccc2ncn(-c3ccc4c(c3)CCN4)c2n1.CCN=C=NCCCN(C)C.CN(C)CCCC(=O)O.CN(C)c1ccncc1.Cl.Cl.ClCCl>>C=Cc1ccc2ncn(-c3ccc4c(c3)CCN4C(=O)CCCN(C)C)c2n1",
        "output": "315"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)c1ccc(CCO)c(C(C)(C)C)c1.Cc1ccccc1.O=S(Cl)Cl>>CC(C)(C)c1ccc(CCCl)c(C(C)(C)C)c1",
        "output": "96"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1c(-c2ccc(OCc3ccccc3)cc2)c(C#N)c(CC)n1C.CCOC(C)=O.[OH-].[OH-].[Pd+2]>>CCOC(=O)c1c(-c2ccc(O)cc2)c(C#N)c(CC)n1C",
        "output": "23"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)SCC(C)C(=O)Cl.N[C@@H](CCC(=O)O)C(=O)O>>CC(=O)SCC(C)C(=O)N[C@@H](CCC(=O)O)C(=O)O",
        "output": "585"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.Cl[Cu].O.O=[N+]([O-])c1ccc(F)cc1.Oc1cc(F)ccc1F.[H-].[Na+]>>O=[N+]([O-])c1ccc(Oc2cc(F)ccc2F)cc1",
        "output": "564"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.ClCCCl.O=C1C2=CCCCC2C(=O)N1c1cc(SC2(C(=O)O)CC2)c(Cl)cc1F.O=S(Cl)Cl>>O=C1C2=CCCCC2C(=O)N1c1cc(SC2(C(=O)Cl)CC2)c(Cl)cc1F",
        "output": "53"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.O=C(OCC1c2ccccc2-c2ccccc21)N1CCC(C(=O)O)(c2ccc(Br)cc2)CC1>>O=C(OCC1c2ccccc2-c2ccccc21)N1CCC(CO)(c2ccc(Br)cc2)CC1",
        "output": "231"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.O=C([O-])[O-].Oc1cccnc1Cc1ccc(Br)cc1F.[K+].[K+]>>COc1cccnc1Cc1ccc(Br)cc1F",
        "output": "661"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC1(CC)OC(=O)Nc2ccc(OCCCCCl)cc21.Sc1ccc(C2CCCCC2)cc1>>CCC1(CC)OC(=O)Nc2ccc(OCCCCSc3ccc(C4CCCCC4)cc3)cc21",
        "output": "460"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCc1ccc(C(=O)Cl)cc1.ClCCl.O=C(c1cccs1)N(CC1C2CNCC21)c1ccc(N2CCOCC2)c(F)c1>>CCc1ccc(C(=O)N2CC3C(C2)C3CN(C(=O)c2cccs2)c2ccc(N3CCOCC3)c(F)c2)cc1",
        "output": "201"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COc1ccc2c(c1)CCNC2=O.ClCCl.O=C([O-])O.[Na+].[Na+].[OH-]>>O=C1NCCc2cc(O)ccc21",
        "output": "786"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1c(N)cccc1Cl.O=[N+]([O-])c1cccnc1Cl>>Cc1c(Cl)cccc1Nc1ncccc1[N+](=O)[O-]",
        "output": "434"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)C1CC(O)C1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.c1ccncc1>>Cc1ccc(S(=O)(=O)OC2CC(C(=O)OC(C)(C)C)C2)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc(N2CCCCC2)cc1.CS(=O)(=O)c1ccc(-c2cccn3nc(N)nc23)cc1>>CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4ccc(N5CCCCC5)cc4)nc23)cc1",
        "output": "970"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc(C(=O)Cl)cc(OC)c1OC.COc1ccccc1.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(C(=O)c2cc(OC)c(OC)c(OC)c2)cc1",
        "output": "61"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[Si](C)(C)Oc1ccc(N)c([N+](=O)[O-])c1.CO.ClCCl.[C].[Pd]>>CC(C)(C)[Si](C)(C)Oc1ccc(N)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC=O.Nc1cccc(-c2cccc(Cl)c2)c1>>CCCCNc1cccc(-c2cccc(Cl)c2)c1",
        "output": "336"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)COC(=O)N1c2ccccc2C=CC1OCC(C)C.CCCCCCCCCCC[C@H](CC(=O)N[C@@H](CO)CCCN)OCc1ccccc1.ClCCl.O=C(O)CCCCCNC(=O)OCc1ccccc1>>CCCCCCCCCCC[C@H](CC(=O)N[C@@H](CO)CCCNC(=O)CCCCCNC(=O)OCc1ccccc1)OCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOCCC(N)=NO.CCc1ccc(C2CC(C(=O)O)CN(C(=O)N3CCC(O)CC3)C2)cc1>>CCOCCc1noc(C2CC(c3ccc(CC)cc3)CN(C(=O)N3CCC(O)CC3)C2)n1",
        "output": "728"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#CCOc1cc(O)c2c(=O)cc(-c3ccc(OC)c(OC)c3)oc2c1.CC(C)=O.COS(=O)(=O)OC.ClC(Cl)Cl.O=C([O-])[O-].[K+].[K+]>>C#CCOc1cc(OC)c2c(=O)cc(-c3ccc(OC)c(OC)c3)oc2c1",
        "output": "317"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(CO)n1cc(C(=O)c2cncc(N)c2)c2cncc(F)c21.O=C(O)Cn1cc(C(F)(F)F)cn1>>CC(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(C(F)(F)F)cn3)c2)c2cncc(F)c21",
        "output": "724"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)cc1OCc1ccccc1.Cc1cccc(S(=O)(=O)Cl)c1.Cl>>COc1ccc(C2=NN(C3CCN(S(=O)(=O)c4cccc(C)c4)CC3)C(=O)C2(C)C)cc1OCc1ccccc1",
        "output": "99"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Fc1cccc(CBr)c1F.Nc1cc(O)nc(S)n1.O.O.[Na+].[OH-]>>Nc1cc(O)nc(SCc2cccc(F)c2F)n1",
        "output": "699"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1onc(-c2ccncn2)c1COc1ccc(C(=O)O)cn1.NCCO>>Cc1onc(-c2ccncn2)c1COc1ccc(C(=O)NCCO)cn1",
        "output": "674"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1cnc(Cc2ccccc2)c2ccccc12.C1COCCO1.CC(C)(C)[O-].N#Cc1ccc(N2CCNCC2)nc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>N#Cc1ccc(N2CCN(c3cnc(Cc4ccccc4)c4ccccc34)CC2)nc1",
        "output": "597"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)Br.O=C1c2cnccc2-c2c1c(Cl)nc1cc(O)ccc21>>CC(C)Oc1ccc2c3c(c(Cl)nc2c1)C(=O)c1cnccc1-3",
        "output": "153"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccccc1C.Cl.ClCCNCCCl.Nc1ccc(F)c(Cl)c1>>Fc1ccc(N2CCNCC2)cc1Cl",
        "output": "640"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCN[C@@H](CN(c2ccccc2)S(C)(=O)=O)C1.CCN(C(C)C)C(C)C.OC(c1cnc(Cl)nc1)(C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N1CCN(c2ncc(C(O)(C(F)(F)F)C(F)(F)F)cn2)[C@@H](CN(c2ccccc2)S(C)(=O)=O)C1",
        "output": "36"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)OCc1cccc(C(C)C)c1F.ClCCl.O.[Na+].[OH-]>>CC(C)c1cccc(CO)c1F",
        "output": "497"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.COc1cccc(N)c1.Cc1onc2c1c(=O)n(-c1cccc(CC(=O)O)n1)c1cccc(Cl)c21.ClCCl.ClCCl>>COc1cccc(NC(=O)Cc2cccc(-n3c(=O)c4c(C)onc4c4c(Cl)cccc43)n2)c1",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O.COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccccc4)cc3)cc2C1=O.O=C(Cl)c1ccc(F)cc1C(F)(F)F>>COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccc(F)cc4C(F)(F)F)cc3)cc2C1=O",
        "output": "11"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1ccc2c(C3CCCCC3)c(Br)n(CC(=O)N3CCOCC3)c2c1.O=C([O-])O.OB(O)c1ccc2ncc(-c3ccccc3)cc2c1.[Na+].c1ccc([PH](c2ccccc2)(c2ccccc2)[Pd]([PH](c2ccccc2)(c2ccccc2)c2ccccc2)([PH](c2ccccc2)(c2ccccc2)c2ccccc2)[PH](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccc4ncc(-c5ccccc5)cc4c3)n(CC(=O)N3CCOCC3)c2c1",
        "output": "869"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCCCCCCCCCCCCC(=O)Cl.CCN(CC)CC.ClCCl.Nc1cccc([N+](=O)[O-])c1>>CCCCCCCCCCCCCCCCCC(=O)Nc1cccc([N+](=O)[O-])c1",
        "output": "9"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.OCCCc1ccco1>>O=CCCc1ccco1",
        "output": "142"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.CCO.O=C(O)c1ccc([N+](=O)[O-])cc1Cl.[C].[H][H].[Pd]>>Nc1ccc(C(=O)O)c(Cl)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cc(CO)cc(OC)c1.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>COc1cc(C=O)cc(OC)c1",
        "output": "179"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COC(=O)/C=C/c1c(Cl)nc(C)n1Cc1ccc(-c2ccco2)cc1Cl.Cl.[Na+].[OH-]>>Cc1nc(Cl)c(/C=C/C(=O)O)n1Cc1ccc(-c2ccco2)cc1Cl",
        "output": "58"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC1(C)C(N)CC1C(=O)O.CO.ClCCCl.O=Cc1ccc2c(C(F)(F)F)c(O[C@@H]3CC[C@H](C(F)(F)F)CC3)ccc2c1.[Na+]>>CC1(C)C(NCc2ccc3c(C(F)(F)F)c(O[C@@H]4CC[C@H](C(F)(F)F)CC4)ccc3c2)CC1C(=O)O",
        "output": "468"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN.COC(=O)[C@H](C)Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc4cscn4)c3)c12>>CNC(=O)[C@H](C)Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc4cscn4)c3)c12",
        "output": "392"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCOC(=O)c1cccc(-c2cc(Nc3ccc(OC)c(OC)n3)c3nccn3n2)c1.Cl.O.[Li+].[OH-]>>COc1ccc(Nc2cc(-c3cccc(C(=O)O)c3)nn3ccnc23)nc1OC",
        "output": "5"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.O=C(OCc1ccccc1)N1CCC(n2c(=O)[nH]c3nnccc32)CC1.[Pd]>>O=c1[nH]c2nnccc2n1C1CCNCC1",
        "output": "428"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCN1.CC#N.O.O=C([O-])[O-].O=C1CCc2cc([N+](=O)[O-])ccc2N1CCCCl.[K+].[K+]>>O=C1CCc2cc([N+](=O)[O-])ccc2N1CCCN1CCOCC1",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCO.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1ccc(-c2ccc(CN)cc2)cc1.ClCCl.Cn1cc(N2Cc3cccc(-c4ccc(C(F)(F)F)cc4)c3C2=O)cc1C(=O)O.F[B-](F)(F)F>>Cc1ccc(-c2ccc(CNC(=O)c3cc(N4Cc5cccc(-c6ccc(C(F)(F)F)cc6)c5C4=O)cn3C)cc2)cc1",
        "output": "905"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCCCC1.CC(C)(C)OC(=O)NCC(=O)O.CCN(CC)CC.CCOC(C)=O.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1ccc(C(=O)Cn2c(-c3nonc3N)nc3ccccc32)cc1>>CC(C)(C)OC(=O)NCC(=O)Nc1ccc(C(=O)Cn2c(-c3nonc3N)nc3ccccc32)cc1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCCCC.CCOCC.COC(=O)c1ccc2cccnc2c1-c1cc(F)cc(F)c1.O.O=C([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[K+].[K+].[Li+].[Na+].[OH-]>>OCc1ccc2cccnc2c1-c1cc(F)cc(F)c1",
        "output": "444"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCc1cccc2ccccc12.CN(C)C=O.C[C@@H](C(=O)N[C@H]1CSc2c(N)cccc2NC1=O)N(C)C(=O)OC(C)(C)C.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])[O-].[K+].[K+]>>C[C@@H](C(=O)N[C@H]1CSc2c(N)cccc2N(Cc2cccc3ccccc23)C1=O)N(C)C(=O)OC(C)(C)C",
        "output": "688"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CS(=O)(=O)Cl.NCc1cccc(-c2nc(=O)c3ccccc3s2)n1.O.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>CS(=O)(=O)NCc1cccc(-c2nc(=O)c3ccccc3s2)n1",
        "output": "493"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1cc2c(C(=O)Cc3c(Cl)cncc3Cl)ccc(OC)c2o1.CO.Cl.[Na+].[OH-]>>COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c2cc(C(=O)O)oc12",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=c1[nH]c(Cl)cc2ccccc12.OCC1CNCCN1>>O=c1[nH]c(N2CCNC(CO)C2)cc2ccccc12",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc2c(c1)CCCC(c1ccc(S(C)(=O)=O)cc1)=C2CCCCCO.C[S-].[Na+]>>CS(=O)(=O)c1ccc(C2=C(CCCCCO)c3ccc(O)cc3CCC2)cc1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CC(=O)Cl.ClCCl.NC(=O)c1cn(C2CCNC2)nc1-c1ccc(Oc2ccccc2)cc1>>C=CC(=O)N1CCC(n2cc(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)n2)C1",
        "output": "135"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.Cc1ccc(C(=O)CCC(=O)O)c(O)c1.Cl>>COC(=O)CCC(=O)c1ccc(C)cc1O",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1cccc(O)c1.Cl.Cn1c(C(F)(F)F)cc(=O)n(-c2cc(F)c([N+](=O)[O-])cc2F)c1=O.O=C([O-])[O-].[K+].[K+]>>COc1cccc(Oc2cc(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)c(F)cc2[N+](=O)[O-])c1",
        "output": "564"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "B.C1CCOC1.CO.CSC.O=C(CCCCl)N(c1ccc(F)cc1)c1ccc(F)cc1>>Fc1ccc(N(CCCCCl)c2ccc(F)cc2)cc1",
        "output": "112"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.COC(=O)c1cc(Oc2ccc([N+](=O)[O-])cc2)cc(C(=O)OC)c1.[H][H].[Pd]>>COC(=O)c1cc(Oc2ccc(N)cc2)cc(C(=O)OC)c1",
        "output": "335"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)c1ccc2c(c1)nc(-c1ccc3ncc(-c4ccccc4)nc3c1)n2C1CCCCC1>>O=C(O)c1ccc2c(c1)nc(-c1ccc3ncc(-c4ccccc4)nc3c1)n2C1CCCCC1",
        "output": "5"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.CS(C)=O.Fc1ccc2[nH]cc(CCCBr)c2c1.NC(=O)c1ccc(F)c2c1CC(N)CO2>>NC(=O)c1ccc(F)c2c1CC(NCCCc1c[nH]c3ccc(F)cc13)CO2",
        "output": "147"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "NCCN1CCCCC1.Nc1ncc(-c2nc(N3CCOCC3)c3sc(C(=O)O)cc3n2)cn1>>Nc1ncc(-c2nc(N3CCOCC3)c3sc(C(=O)NCCN4CCCCC4)cc3n2)cn1",
        "output": "736"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1c(C(=O)OC(C)(C)C)oc2cccc(OC(C)C)c12.ClCCl.O=C(O)C(F)(F)F>>Cc1c(C(=O)O)oc2cccc(OC(C)C)c12",
        "output": "569"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCCCC(=O)N(C)Cc1cccc(-c2ccc(CCC(=O)OC)cc2OCCCC)c1.[Li+].[OH-]>>CCCCCC(=O)N(C)Cc1cccc(-c2ccc(CCC(=O)O)cc2OCCCC)c1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cc1cc(C(=O)c2sc(N)nc2-c2ccco2)ccn1.Cl.O.O.O=C(O)c1ccncc1.On1nnc2ccccc21>>Cc1cc(C(=O)c2sc(NC(=O)c3ccncc3)nc2-c2ccco2)ccn1",
        "output": "918"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrBr.CCOC(=O)c1ncc2[nH]c3ccccc3c2n1.ClC(Cl)Cl.c1ccncc1>>CCOC(=O)c1ncc2[nH]c3ccc(Br)cc3c2n1",
        "output": "98"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC#Cc1ccc(Br)cc1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.ClCCl.Cl[Pd]Cl.O.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC#Cc1ccc(B2OC(C)(C)C(C)(C)O2)cc1",
        "output": "942"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCO.O=C(O)C(CC(=O)N1C[C@@H]2CCCC[C@@H]2C1)Cc1ccccc1>>CCCOC(=O)C(CC(=O)N1C[C@@H]2CCCC[C@@H]2C1)Cc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#CCN(C)C(=O)c1ccccc1Nc1nc(Cl)ncc1Cl.CN1C(=O)CCCc2cc(N)ccc21>>C#CCN(C)C(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)CCCC(=O)N3C)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NCc1cc(C(F)(F)F)no1.O=C(O)c1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1>>O=C(NCc1cc(C(F)(F)F)no1)c1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1",
        "output": "674"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)CCCCCCCCCO.CN(C)c1ccncc1.O=C(O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2>>CCOC(=O)CCCCCCCCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CN.O=C(O)c1ccc(Br)cc1F>>CC(C)CNC(=O)c1ccc(Br)cc1F",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN.CCN(C(C)C)C(C)C.CN(C)C=O.Cc1ccccc1.O=C(O)CCCCBr.O=S(Cl)Cl>>CCNC(=O)CCCCBr",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCO.CN1CCC(N(C)C(=O)c2ccc(Nc3nc4c(N5CCC(CC(=O)O)(c6ccc(Cl)cc6)CC5)cccn4n3)cc2)CC1.O.O=S(Cl)Cl>>CCOC(=O)CC1(c2ccc(Cl)cc2)CCN(c2cccn3nc(Nc4ccc(C(=O)N(C)C5CCN(C)CC5)cc4)nc23)CC1",
        "output": "47"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccccc1.CC(C)(CO)[N+](=O)[O-].CN(C)C=O>>CC(C)(COCc1ccccc1)[N+](=O)[O-]",
        "output": "464"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C(=O)OC(C)(C)C)C1CCC(Oc2ncnc3sc4c(c23)[C@@H](CC(O)C#N)CC4)CC1.CN(C)C=O.c1c[nH]cn1>>CN(C(=O)OC(C)(C)C)C1CCC(Oc2ncnc3sc4c(c23)[C@@H](CC(C#N)O[Si](C)(C)C(C)(C)C)CC4)CC1",
        "output": "193"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.COC(=O)c1ccc(C(=O)O)nc1.ClCCl.NCCNc1nsc2ccccc12.O=C(Cl)C(=O)Cl>>COC(=O)c1ccc(C(=O)NCCNc2nsc3ccccc23)nc1",
        "output": "137"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CC(=O)Cl.CCN(CC)CC.CCOCC.Cc1cccc(C)c1N.Cl>>C=CC(=O)Nc1c(C)cccc1C",
        "output": "10"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)Oc1cc(F)c(B2OC(C)(C)C(C)(C)O2)c(F)c1.COC(=O)c1nc(Br)c(F)cc1N>>COC(=O)c1nc(-c2c(F)cc(OC(C)C)cc2F)c(F)cc1N",
        "output": "939"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)CBr.COc1cc2c(N3CCC(n4c(=O)c5cc(C)ccc5n(C)c4=O)CC3)ncnc2cc1O>>CCOC(=O)COc1cc2ncnc(N3CCC(n4c(=O)c5cc(C)ccc5n(C)c4=O)CC3)c2cc1OC",
        "output": "123"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "N[C@H]1CCN(CCc2ccccc2)C1.O=C(O)C1(C2CCCCC2)CCCC1>>O=C(N[C@H]1CCN(CCc2ccccc2)C1)C1(C2CCCCC2)CCCC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC[S-].CN(C)C=O.COc1ccc(C(=O)c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1.Cl.[Na+].c1ccccc1>>CC(C)(C)c1cc(C(=O)c2ccc(O)cc2)cc(C(C)(C)C)c1O",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.C[Si](C)(C)C#Cc1sc(N)nc1-c1ccccc1.O=C([O-])[O-].[K+].[K+]>>C#Cc1sc(N)nc1-c1ccccc1",
        "output": "337"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cc(N)ccc1-c1ccnnc1.F[P-](F)(F)(F)(F)F>>COc1cc(NC(=O)[C@@H](CC(C)C)NC(=O)OC(C)(C)C)ccc1-c1ccnnc1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cl.Nc1nc(C(F)(F)F)nn1CC(=O)O.O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2ccccc2)CN1>>Nc1nc(C(F)(F)F)nn1CC(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1",
        "output": "297"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "N#Cc1ccccc1F.NCCCCO>>N#Cc1ccccc1NCCCCO",
        "output": "572"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)c1ccc(C=Cc2cc3c(cc2Cn2cccn2)C(C)(C)CCC3(C)C)cc1.Cl.O.[Na+].[OH-]>>CC1(C)CCC(C)(C)c2cc(Cn3cccn3)c(/C=C/c3ccc(C(=O)O)cc3)cc21",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)n1ncc2c(C(=O)O)cc(C3CC3)nc21.CN(C)C=O.CN1CCOCC1.Cc1cc(C(C)C)c(CN)c(=O)[nH]1.ClCCCl.O=C(O)C(F)(F)F.On1nnc2cccnc21>>Cc1cc(C(C)C)c(CNC(=O)c2cc(C3CC3)nc3c2cnn3C(C)C)c(=O)[nH]1",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(N2CCN(CCCCl)CC2)cc1.Cl.O=C1CCCc2c(O)cccc21>>COc1ccc(N2CCN(CCCOc3cccc4c3CCCC4=O)CC2)cc1",
        "output": "74"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CC=C(c2ccn3c(-c4ccnc(-c5ccccc5)c4)cnc3c2)CC1.CO.Cl>>C1=C(c2ccn3c(-c4ccnc(-c5ccccc5)c4)cnc3c2)CCNC1",
        "output": "800"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)C(C)(C)Sc1ccc(OCCCn2c(CC)nc3ccccc3c2=O)cc1.O.[Li+].[OH-]>>CCc1nc2ccccc2c(=O)n1CCCOc1ccc(SC(C)(C)C(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)CCCCCOc1cc2c(cc1N)nc(-c1ccccc1)n2-c1ccc(C)c(C)c1.O=S(=O)(Cl)c1ccc(Cl)cc1>>COC(=O)CCCCCOc1cc2c(cc1NS(=O)(=O)c1ccc(Cl)cc1)nc(-c1ccccc1)n2-c1ccc(C)c(C)c1",
        "output": "68"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)C(O)C(Oc1ccc(Br)cc1)n1cncn1.CCN(CC)CC.C[Si](C)(C)Cl>>CC(C)(C)C(O[Si](C)(C)C)C(Oc1ccc(Br)cc1)n1cncn1",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC[C@@H]1CC[C@@H](C2CC=C(c3cc(F)ccc3F)CC2)CC1.CCOC(C)=O.[C].[Pd]>>CCC[C@@H]1CC[C@@H](C2CCC(c3cc(F)ccc3F)CC2)CC1",
        "output": "249"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cn2c(Br)cccc2n1.O=C(O)c1cn2cccc(Br)c2n1>>O=C(O)c1cn2c(Br)cccc2n1",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CO.COC(=O)c1cccc(-c2cc(C)cc(Nc3nccc(C(F)(F)F)n3)c2)c1.Cl.O.[Cl-].[Na+].[Na+].[OH-]>>Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cccc(C(=O)O)c2)c1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "FC(F)(F)c1nnc(N2CCNCC2)s1.O=C(O)C(F)(F)F.O=C(O)c1cc([N+](=O)[O-])ccc1N1CCOCC1>>O=C(c1cc([N+](=O)[O-])ccc1N1CCOCC1)N1CCN(c2nnc(C(F)(F)F)s2)CC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.O=C(O)c1cc(Cl)ccc1-n1cnnn1.On1nnc2cccnc21.[Cl-].[NH4+]>>NC(=O)c1cc(Cl)ccc1-n1cnnn1",
        "output": "358"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.CN(C)C=O.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C.F[P-](F)(F)(F)(F)F.NCCCCO.O.O=C([O-])O.[Na+]>>COc1cc(C(=O)NCCCCO)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CCNC.CN(C)C=O.Cl.Cl.O.O=C(O)CCSc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)cc1F.On1nnc2ccccc21>>CCN(C)C(=O)CCSc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)cc1F",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)c1cccc(-c2ccc(CC3CCN(C4CCCCC4)C3=O)c(Cl)c2)c1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)c1cccc(-c2ccc(CC3CCN(C4CCCCC4)C3=O)c(Cl)c2)c1",
        "output": "752"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1cc2cc(-c3ccc(Cl)cc3)ccc2s1.O.O.[Li+].[OH-]>>O=C(O)c1cc2cc(-c3ccc(Cl)cc3)ccc2s1",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.CCOCC.CN1CCCC1=O.O=C([O-])[O-].O=C1c2ccccc2C(=O)N1CCCc1cccc(O)c1.[Cs+].[Cs+]>>O=C1c2ccccc2C(=O)N1CCCc1cccc(OCc2ccccc2)c1",
        "output": "127"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCN.CCO.O.O=C([O-])[O-].O=[N+]([O-])c1cc(-c2nc3ccccc3o2)ccc1F.[K+].[K+]>>CCCCNc1ccc(-c2nc3ccccc3o2)cc1[N+](=O)[O-]",
        "output": "572"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.COc1ccc2[nH]c(C(=O)Nc3cc(NC(=O)OCc4ccccc4)c4ccccc4c3CCO)cc2c1.CS(=O)(=O)Cl.ClCCl>>COc1ccc2[nH]c(C(=O)Nc3cc(NC(=O)OCc4ccccc4)c4ccccc4c3CCOS(C)(=O)=O)cc2c1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O=C(O)C=Cc1ccc(F)cc1.[Pd]>>O=C(O)CCc1ccc(F)cc1",
        "output": "344"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1nc(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2Cc2nc(-c3ccc(F)cc3)c[nH]2)c(-c2ccc(F)cc2)s1.O=C(O)C(F)(F)F>>Cc1nc(C(=O)N2CCNCC2Cc2nc(-c3ccc(F)cc3)c[nH]2)c(-c2ccc(F)cc2)s1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Nc1ccc2sc3ccccc3c2c1.O.O.O=C(O)Cn1cncn1.On1nnc2ccccc21>>O=C(Cn1cncn1)Nc1ccc2sc3ccccc3c2c1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1C(=O)OCCc2cc(N)ccc21.CNC(=O)c1cc(C)on1.CNC(=O)c1noc(C)c1Nc1nc(Cl)ncc1Cl>>CNC(=O)c1noc(C)c1Nc1nc(Nc2ccc3c(c2)CCOC(=O)N3C)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)[Si](OCCc1cc(Cl)ccc1[C@@]1(O)CCN(C(=O)OC(C)(C)C)C[C@@H]1O)(C(C)C)C(C)C.CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.COCCCN1C(=O)COc2ccc(CBr)cc21.[H-].[I-].[Na+]>>COCCCN1C(=O)COc2ccc(CO[C@H]3CN(C(=O)OC(C)(C)C)CC[C@]3(O)c3ccc(Cl)cc3CCO[Si](C(C)C)(C(C)C)C(C)C)cc21",
        "output": "464"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.ClCCl.Cn1nc(N2CCNCC2)c(=O)n(C)c1=O.O.O=C(Cl)c1cc(C(F)(F)F)ccc1C(F)(F)F>>Cn1nc(N2CCN(C(=O)c3cc(C(F)(F)F)ccc3C(F)(F)F)CC2)c(=O)n(C)c1=O",
        "output": "201"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)O.CCOC(C)=O.Cl[Sn](Cl)(Cl)Cl.Nc1ncc(Br)cc1[N+](=O)[O-].O.O.[BH4-].[Na+]>>Nc1cc(Br)cnc1N",
        "output": "269"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C)C=O.Cl.[Li]C(C)CC.c1ccc(-c2nnn[nH]2)cc1>>O=Cc1ccccc1-c1nnn[nH]1",
        "output": "239"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)N.CC(C)NC(=O)c1cc(Cl)ccn1.Nc1ccc(O)cc1.O=C(Cl)c1cc(Cl)ccn1>>CC(C)NC(=O)c1cc(Oc2ccc(N)cc2)ccn1",
        "output": "351"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCNCC(O)(CNc1cc(C)cc2c1cnn2-c1ccccc1)C(F)(F)F.O=C(O)c1cccs1>>CCN(CC(O)(CNc1cc(C)cc2c1cnn2-c1ccccc1)C(F)(F)F)C(=O)c1cccs1",
        "output": "857"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1cnc2cc(C(F)(F)F)c(F)cc2c1.Cl.[Na+].[OH-]>>O=C(O)c1cnc2cc(C(F)(F)F)c(F)cc2c1",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCCC1=O.COCCOCCOCCS(=O)(=O)c1cc(N)cc(OC)c1.COc1c(NC(=O)Nc2ccc(Oc3ccnc(Cl)c3)c3ccccc23)cc(C(C)(C)C)cc1NS(C)(=O)=O.COc1ccc(OC)c(P(C2CCCCC2)C2CCCCC2)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.O=C([O-])[O-].[K+].[K+]>>COCCOCCOCCS(=O)(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(NS(C)(=O)=O)c4OC)c4ccccc34)ccn2)cc(OC)c1",
        "output": "434"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CI.CS(C)=O.O.O=[N+]([O-])c1ccc(-n2cnc(Cl)n2)c(O)c1.[K+].[OH-]>>COc1cc([N+](=O)[O-])ccc1-n1cnc(Cl)n1",
        "output": "62"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O.O=C(O)c1ccc2cc[nH]c2c1>>O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc2cc[nH]c2c1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.C[C@@H](C1CC1)N(Cc1ccccc1)C(=O)CN1C(=O)N[C@]2(CCc3cc(C#C[Si](C)(C)C)ccc32)C1=O.O=C([O-])[O-].[K+].[K+]>>C#Cc1ccc2c(c1)CC[C@]21NC(=O)N(CC(=O)N(Cc2ccccc2)[C@@H](C)C2CC2)C1=O",
        "output": "337"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.Cl.O=C1c2ccccc2OCC1c1ccccc1.[Zn]>>c1ccc(C2COc3ccccc3C2)cc1",
        "output": "92"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)C1(NC(=O)c2cc3ccccc3cc2NC(=O)Nc2c(C)cc(Br)cc2C)CCCCCC1.Cl.[Li+].[OH-]>>Cc1cc(Br)cc(C)c1NC(=O)Nc1cc2ccccc2cc1C(=O)NC1(C(=O)O)CCCCCC1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CC(=O)N1c2ccc(-c3ccc(C(=O)O)cn3)cc2[C@H](NC(=O)OC(C)(C)C)C[C@@H]1C.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F>>CC(=O)N1c2ccc(-c3ccc(C(=O)N4CCOCC4)cn3)cc2[C@H](NC(=O)OC(C)(C)C)C[C@@H]1C",
        "output": "256"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)CCC(C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O.COC(=O)CCC(C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OCc1ccccc1.C[C@H](N)C(=O)OCc1ccccc1.N[C@@H](Cc1ccc(O)cc1)C(=O)OCc1ccccc1>>CC(CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O=C(Nc1n[nH]c2nnc(-c3cccc(F)c3F)cc12)C1CCN(Cc2ccccc2)CC1.O=C[O-].[NH4+].[Pd]>>O=C(Nc1n[nH]c2nnc(-c3cccc(F)c3F)cc12)C1CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COc1cc(OCCO)ccc1[N+](=O)[O-].[Pd]>>COc1cc(OCCO)ccc1N",
        "output": "202"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C(=O)O)c1ccc(N)c(F)c1.CCO.O=S(Cl)Cl>>CCOC(=O)C(C)c1ccc(N)c(F)c1",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.COc1cccc(OC)c1-c1c[nH]c2ncc(-c3cccc(O)c3)cc12.ClCCl>>Oc1cccc(-c2cnc3[nH]cc(-c4c(O)cccc4O)c3c2)c1",
        "output": "20"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(C)=O.N#CCc1cccc(-c2nn(C3CCCC3)c3cc[nH]c(=O)c23)c1.O.O=C([O-])[O-].OO.[K+].[K+]>>NC(=O)Cc1cccc(-c2nn(C3CCCC3)c3cc[nH]c(=O)c23)c1",
        "output": "632"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cc1cc(Oc2ccccc2)cc(C)c1C(=O)CBr.NC(N)=S>>Cc1cc(Oc2ccccc2)cc(C)c1-c1csc(N)n1",
        "output": "716"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCC(=O)O.CCN(CC)CC.CO.ClC(Cl)Cl.O=S(=O)(On1nnc2ccc(Cl)cc21)c1ccc(Cl)cc1>>CCCCCCC(=O)OC",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C(O)c1ccc(Cc2ccccc2C(=O)O)c([N+](=O)[O-])c1.O=[Pt]=O.[Pd]>>Nc1cc(C(=O)O)ccc1Cc1ccccc1C(=O)O",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCCc1cccc(CCC)c1-n1cc[n+](-c2c(CCC)cccc2CCC)c1.Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc2cnc(Cl)cc2n(C)c1=O.NCc1cccnc1.[Cl-]>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc2cnc(NCc3cccnc3)cc2n(C)c1=O",
        "output": "110"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cnc(Cl)nc1C(F)(F)F.Cc1c(Cl)nnc(N2CCN[C@H](C)C2)c1C>>CCOC(=O)c1cnc(N2CCN(c3nnc(Cl)c(C)c3C)C[C@H]2C)nc1C(F)(F)F",
        "output": "36"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.Nc1ccc([N+](=O)[O-])cn1.O=C(Cl)C1CCCCC1>>O=C(Nc1ccc([N+](=O)[O-])cn1)C1CCCCC1",
        "output": "332"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)CCc1c(F)cccc1F.CCOC(C)=O.O=C([O-])C(O)C(O)C(=O)[O-].[Al+3].[H-].[H-].[H-].[H-].[K+].[Li+].[Na+]>>OCCCc1c(F)cccc1F",
        "output": "225"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN1Cc2cc(-c3ccc(-c4cncc(N)c4)s3)ccc2C1=O.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CN1Cc2cc(-c3ccc(-c4cncc(NS(=O)(=O)c5ccccc5[N+](=O)[O-])c4)s3)ccc2C1=O",
        "output": "554"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.COc1cc2c(Cl)ncnc2cc1OCCCN1CCCCC1.O=C([O-])[O-].Oc1cccc2[nH]ccc12.[K+].[K+]>>COc1cc2c(Oc3cccc4[nH]ccc34)ncnc2cc1OCCCN1CCCCC1",
        "output": "668"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)c1ccc(-c2ccc(F)cc2)c(OCC)c1.Cl.[H-]>>CCOc1cc(CO)ccc1-c1ccc(F)cc1",
        "output": "311"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.Cc1cc(NC(=O)C(C)(C)NC(=O)c2ccc(C#C[Si](C)(C)C)s2)ccc1N1CCOCC1=O.ClCCl.O.O.O.[F-]>>C#Cc1ccc(C(=O)NC(C)(C)C(=O)Nc2ccc(N3CCOCC3=O)c(C)c2)s1",
        "output": "337"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(CCl)COC1.CN(C)C=O.C[C@@H](NC(=O)[C@H]1C[C@@H]1c1cccc(O)c1)c1ccc(OCC(F)(F)F)cn1.O.O=C([O-])[O-].[K+].[K+]>>C[C@@H](NC(=O)[C@H]1C[C@@H]1c1cccc(OCC2(C)COC2)c1)c1ccc(OCC(F)(F)F)cn1",
        "output": "74"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc2cc(-c3ccnc([N+](=O)[O-])c3)sc2c1.O=[N+]([O-])c1cc(-c2cc3ccc(O)cc3o2)ccn1>>O=[N+]([O-])c1cc(-c2cc3ccc(O)cc3s2)ccn1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(N2CCN(Cc3cnc4c(c3)NC(=O)[C@@H]3CCCN43)CC2)nc1>>CCNC(=O)c1ccc(N2CCN(Cc3cnc4c(c3)NC(=O)[C@@H]3CCCN43)CC2)nc1",
        "output": "674"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCc1cccs1.CN(C)C=O.O=C1CCC(=O)N1Br>>CCCc1ccc(Br)s1",
        "output": "807"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.NC1CCOCC1.O=Cc1cccc([N+](=O)[O-])c1.[Na+].[Na+].[OH-]>>O=[N+]([O-])c1cccc(CNC2CCOCC2)c1",
        "output": "468"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCC(=O)CC1.O=[N+]([O-])c1ccc2cc[nH]c2c1>>CN1CC=C(c2c[nH]c3cc([N+](=O)[O-])ccc23)CC1",
        "output": "607"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cc1cc(F)ccc1-c1cc(C(N)=O)c2[nH]cc(C3CCN(C(=O)OC(C)(C)C)CC3)c2c1.Cl.NC(=O)c1cc(-c2cccs2)cc2c(C3CCNCC3)c[nH]c12>>Cc1cc(F)ccc1-c1cc(C(N)=O)c2[nH]cc(C3CCNCC3)c2c1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#Cc1cc(Nc2ncnc3cc(OC)c(OCCCCl)cc23)ccc1F.C1COC2CNCC2O1.CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.O=C([O-])[O-].[I-].[K+].[K+]>>C#Cc1cc(Nc2ncnc3cc(OC)c(OCCCN4CC5OCCOC5C4)cc23)ccc1F",
        "output": "138"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NCCC(c1ccc(F)cc1)c1ccc(F)cc1.O=C(O)c1ccncc1>>O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)c1ccncc1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CNCCO.N#Cc1c(N)cccc1F.[H-].[Na+]>>CNCCOc1cccc(N)c1C#N",
        "output": "485"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccccc1.NC1CC1.O=Cc1ccc(Cl)cc1>>Clc1ccc(C=NC2CC2)cc1",
        "output": "52"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCO.COC[C@H](C)N.Clc1cncc(Cl)n1>>COC[C@H](C)Nc1cncc(Cl)n1",
        "output": "148"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.C1CCOC1.CCN(CC)CC.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N.O=C(Cl)C12CC3CC(CC(C3)C1)C2>>CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)C12CC3CC(CC(C3)C1)C2",
        "output": "159"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.[C].[N-]=[N+]=NC[C@@H]1[C@@H](Nc2nccc(N3CCCCCC3)n2)CCN1C1CCCCC1.[Pd]>>NC[C@@H]1[C@@H](Nc2nccc(N3CCCCCC3)n2)CCN1C1CCCCC1",
        "output": "89"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O=[N+]([O-])c1cnc2ccccc2c1O.[Pd]>>Nc1cnc2ccccc2c1O",
        "output": "269"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1c(CN2CCNCC2)sc2c(N3CCOCC3)nc(Cl)nc12.Cl.O=C(O)CO>>Cc1c(CN2CCN(C(=O)CO)CC2)sc2c(N3CCOCC3)nc(Cl)nc12",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1c(Cl)ccnc1C.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COc1c(Cl)ccnc1CBr",
        "output": "590"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2F)c(=O)n([C@@H]2C[C@H](OCC(C)(C)O)C2)c2ncnn12.CCOC(C)=O.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2F)c(=O)n([C@@H]2C[C@H](OCC(C)(C)O)C2)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CNCc1cccnc1.COc1cc2ncc3c(N)nc(-c4cncc(OC[C@@H](N)COS(C)(=O)=O)c4)cc3c2cc1OC.Cl.[I-].[Na+]>>COc1cc2ncc3c(N)nc(-c4cncc(OC[C@@H](N)CN(C)Cc5cccnc5)c4)cc3c2cc1OC",
        "output": "496"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(S(=O)(=O)c2c(C(C)C)nn3ccccc23)cc1.Cl.O.c1ccncc1>>CC(C)c1nn2ccccc2c1S(=O)(=O)c1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cccc(C(=O)Cl)c1C.Cc1cccc(C(=O)O)c1C.Cc1cccc2c1NC(=O)CC(=O)N2c1ccc(N)cc1>>Cc1cccc(C(=O)Nc2ccc(N3C(=O)CC(=O)Nc4c(C)cccc43)cc2)c1C",
        "output": "11"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.OCC1CCOCC1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCC2CCOCC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.ClCCl.Nc1ccc(S(=O)(=O)C(F)(F)F)c(Cl)c1.O.O=C([O-])[O-].S=C(Cl)Cl.[Ca+2]>>O=S(=O)(c1ccc(N=C=S)cc1Cl)C(F)(F)F",
        "output": "114"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CO.COCC(=O)Nc1cc(Oc2ccc([N+](=O)[O-])c(C)c2)ccn1.[H][H].[Pt]>>COCC(=O)Nc1cc(Oc2ccc(N)c(C)c2)ccn1",
        "output": "335"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(C)=O.Fc1cccc(C(F)CBr)c1.[N-]=[N+]=[N-].[Na+]>>[N-]=[N+]=NCC(F)c1cccc(F)c1",
        "output": "622"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1Cc2ccc(C3CCNCC3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1.Cl.O=C(Cl)N1CCCC1>>CC1Cc2ccc(C3CCN(C(=O)N4CCCC4)CC3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1",
        "output": "258"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "FC(F)(F)c1cccc(CBr)c1.O=C(c1ccccc1)c1cnc2c(C(F)(F)F)cccc2c1-c1cccc(O)c1>>O=C(c1ccccc1)c1cnc2c(C(F)(F)F)cccc2c1-c1cccc(OCc2cccc(C(F)(F)F)c2)c1",
        "output": "127"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1Cc2cc(Cl)c(S(=O)(=O)Cl)cc2C1=O.N>>CC1Cc2cc(Cl)c(S(N)(=O)=O)cc2C1=O",
        "output": "245"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CNc1cc(OC(F)(F)C(F)OC(F)(F)C(F)(F)C(F)(F)F)nn1-c1cc(SCC(F)(F)F)c(C)cc1F.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>CNc1cc(OC(F)(F)C(F)OC(F)(F)C(F)(F)C(F)(F)F)nn1-c1cc(S(=O)CC(F)(F)F)c(C)cc1F",
        "output": "500"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CSc1nc(C(=O)N2Cc3ccccc3C2)c2c(C#N)cn(COCC[Si](C)(C)C)c2n1.NCCN.[F-]>>CSc1nc(C(=O)N2Cc3ccccc3C2)c2c(C#N)c[nH]c2n1",
        "output": "897"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)C[C@@H](CCCC1CCCCC1)c1nc(Cc2cccnc2)no1.Cl>>O=C(O)C[C@@H](CCCC1CCCCC1)c1nc(Cc2cccnc2)no1",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Brc1cncc(CN2CCCCC2)c1.CC1(C)OB(c2cnc3c(c2)c(C=O)nn3C2CCCCO2)OC1(C)C.COCCOC.Cl[Pd]Cl.O.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=Cc1nn(C2CCCCO2)c2ncc(-c3cncc(CN4CCCCC4)c3)cc12",
        "output": "967"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.COC(=O)CCCS(=O)(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)C1c1ccc(C#N)cc1.O.[Li+].[OH-]>>N#Cc1ccc(C2C3=C(CCCC3=O)N(c3cccc(C(F)(F)F)c3)C(=O)N2S(=O)(=O)CCCC(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC[SiH](CC)CC.COC(=O)c1nc(-c2ccc(C)cc2)nc(OCc2ccc(OC)cc2)c1OCc1ccc(OC)cc1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(COc2nc(-c3ccc(C)cc3)nc(C(=O)O)c2OCc2ccc(OC)cc2)cc1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.CN1CCCC1=O.Clc1cnc(Cl)c(Br)c1>>CC(C)(C)OC(=O)N1CCN(c2ncc(Cl)cc2Br)CC1",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(=O)CCCCN1CCCc2ccccc21.ClCCl.O.[Br-].[Br-].[Br-]>>CCOC(=O)CCCCN1CCCc2cc(Br)ccc21",
        "output": "784"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(Cl)c(B(O)O)c1.Nc1c2c(nc3c(Br)cccc13)CN(C1CC1)C2=O>>COc1ccc(Cl)c(-c2cccc3c(N)c4c(nc23)CN(C2CC2)C4=O)c1",
        "output": "833"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCC.CCc1cc(-c2c(CC)cccc2CC)nc(Cl)c1CN(C)[C@H]1CCCc2ccccc21.CN.CN1CCCC1=O.O>>CCc1cc(-c2c(CC)cccc2CC)nc(NC)c1CN(C)[C@H]1CCCc2ccccc21",
        "output": "70"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.Cl.Clc1ncccn1.O=C([O-])O.O=C1CC2CCC(C1)N2.[Na+]>>O=C1CC2CCC(C1)N2c1ncccn1",
        "output": "36"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.OCCc1ccc(CCOC2CCCCO2)cc1>>CS(=O)(=O)OCCc1ccc(CCOC2CCCCO2)cc1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.C1COCCO1.ClC(Cl)Cl.Fc1ccc2[nH]cc(CCBr)c2c1.[Na+].[OH-]>>Fc1ccc2[nH]cc(CCN3CCCC3)c2c1",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1c2ccccc2c(-c2ccc(C=Cc3ccccc3)cc2)c2ccccc12.Cc1ccccc1.O=C([O-])[O-].OB(O)c1ccc(C=C(c2ccccc2)c2ccccc2)cc1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C(=Cc1ccc(-c2c3ccccc3c(-c3ccc(C=C(c4ccccc4)c4ccccc4)cc3)c3ccccc23)cc1)c1ccccc1",
        "output": "837"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)cc1OC.Cl.O=C(Cl)c1cccc(F)c1F>>COc1ccc(C2=NN(C3CCN(C(=O)c4cccc(F)c4F)CC3)C(=O)C2(C)C)cc1OC",
        "output": "201"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(C)(C)OC(=O)C1(Cc2ccc(F)c(N)c2)CC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O.O=C(O)C(c1ccc(Cl)cc1)C1CCCC1(F)F.[Cl-].[NH4+].c1ccncc1>>CC(C)(C)OC(=O)C1(Cc2ccc(F)c(NC(=O)C(c3ccc(Cl)cc3)C3CCCC3(F)F)c2)CC1",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O=C(O)c1ccc2oc3ncccc3c(=O)c2c1>>CCOC(=O)c1ccc2oc3ncccc3c(=O)c2c1",
        "output": "33"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCCCCc1ccccc1.CC(C)(C)OC(=O)NC(CO)(CO)CCc1ccc(O)c(C(F)(F)F)c1.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)NC(CO)(CO)CCc1ccc(OCCCCc2ccccc2)c(C(F)(F)F)c1",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(n2cc(C#N)[nH]c2=O)CC1.ClCCl.O=C(O)C(F)(F)F>>N#Cc1cn(C2CCNCC2)c(=O)[nH]1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1cncc(-c2cc3ccccc3[nH]2)c1.C1CCOC1.CI.[H-].[Na+]>>Cn1c(-c2cncc(Br)c2)cc2ccccc21",
        "output": "191"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)Cn1nc(C(N)=O)c2cc(-c3cncnc3)ccc21.Cl>>NC(=O)c1nn(CC(=O)O)c2ccc(-c3cncnc3)cc12",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[C@H]1CNCCN1S(C)(=O)=O.Cl.O=Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1>>C[C@H]1CN(Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)CCN1S(C)(=O)=O",
        "output": "792"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.N#Cc1ccc(OC[C@H](O)CN)cc1.O>>CC(C)(C)OC(=O)NC[C@@H](O)COc1ccc(C#N)cc1",
        "output": "631"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1nc(N)sc1C(=O)NCc1ccccc1.O=C(Cl)c1ccccc1OC(F)(F)F>>Cc1nc(NC(=O)c2ccccc2OC(F)(F)F)sc1C(=O)NCc1ccccc1",
        "output": "673"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=C(CNc1ccccc1F)OCc1ccccc1.[Pd]>>O=C(O)CNc1ccccc1F",
        "output": "186"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N1CC(C)(C)c2ccccc21.CO.Cl>>CC1(C)CNc2ccccc21",
        "output": "504"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Nc1ccc(Nc2ccc3c(c2[N+](=O)[O-])CCCC3)cc1.CO.[C].[Pd]>>CC(C)(C)OC(=O)Nc1ccc(Nc2ccc3c(c2N)CCCC3)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc2ccnc(O)c2c1.O=P(Cl)(Cl)Cl>>Cc1ccc2ccnc(Cl)c2c1",
        "output": "41"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)COc1cccc2c1CCC[C@H]2NS(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)c(Cl)c1.[Na+].[OH-]>>O=C(O)COc1cccc2c1CCC[C@H]2NS(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)c(Cl)c1",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCCC1=O.CN1CCc2[nH]c3ccc(Cl)cc3c2C1.COc1ccc(CCBr)cc1.O.[K+].[OH-]>>COc1ccc(CCn2c3c(c4cc(Cl)ccc42)CN(C)CC3)cc1",
        "output": "470"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.COc1cccc(OCC(=O)O)c1.Nc1ccccc1NC(=O)c1cc2c(s1)CNCC2.On1nnc2ccccc21>>COc1cccc(OCC(=O)N2CCc3cc(C(=O)Nc4ccccc4N)sc3C2)c1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)N(C)C.CNCCCSC(C)=O.Cl.ClCCCl.Cn1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)c4cc(NC(=O)OC(C)(C)C)cn4C)cn3C)cn2C)cc1C(=O)O>>CC(=O)SCCCN(C)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)c4cc(NC(=O)OC(C)(C)C)cn4C)cn3C)cn2C)cn1C",
        "output": "605"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)c1sc(N2CCN(CCOc3ccccc3)C2=O)cc1C.Cl.[Na+].[OH-]>>Cc1cc(N2CCN(CCOc3ccccc3)C2=O)sc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCO.CN.Clc1cc(COCC2CC2)nc(Cl)n1>>CNc1cc(COCC2CC2)nc(Cl)n1",
        "output": "166"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.CCOCC.COc1ccc(Cl)cc1S(=O)(=O)Oc1cc(C)cc(O)c1.ClCCl.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.OCCCO>>COc1ccc(Cl)cc1S(=O)(=O)Oc1cc(C)cc(OCCCO)c1",
        "output": "478"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1cc(-c2nnc(-c3ccc(C(C)(C)C)cc3)o2)ccc1-c1nnc(-c2ccc(C(C)(C)C)cc2)o1.ClCCl.O=C([O-])[O-].[Na+].[Na+]>>CC(C)(C)c1ccc(-c2nnc(-c3ccc(-c4nnc(-c5ccc(C(C)(C)C)cc5)o4)c(O)c3)o2)cc1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COCC(=O)Cl.Cl.N[C@@H]1CC[C@@H](NC(=O)c2c[nH]c3c(-c4cc(F)ccc4OCC4CC4)ncnc23)CC1>>COCC(=O)N[C@@H]1CC[C@@H](NC(=O)c2c[nH]c3c(-c4cc(F)ccc4OCC4CC4)ncnc23)CC1",
        "output": "45"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CO.COc1ccc(COc2ccc([N+](=O)[O-])c(N)n2)cc1.[Zn]>>COc1ccc(COc2ccc(N)c(N)n2)cc1",
        "output": "269"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NC1CC1>>CC(C)(C)OC(=O)N1CCC(C(=O)NC2CC2)C1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCC(O)c1cc(C(C)(C)C)cc(C(C)(C)C)c1.CCOC(C)=O.ClCCl.O=[Mn]=O>>CCCC(=O)c1cc(C(C)(C)C)cc(C(C)(C)C)c1",
        "output": "32"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CI.CN(C)C=O.COc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1.O.[H-].[Na+]>>COc1ccc(N2CCN(Cc3cn(C)c4ncccc34)CC2)cc1",
        "output": "570"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)Oc1cc(OCc2ccccc2)ccc1OC(=O)c1ccccc1.CCO.CCOC(C)=O.[Pd]>>CC(C)Oc1cc(O)ccc1OC(=O)c1ccccc1",
        "output": "23"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.C1CCOC1.COC(=O)c1cc(-c2ccc(Cl)c(Cl)c2)ccn1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1cc(-c2ccc(Cl)c(Cl)c2)ccn1",
        "output": "546"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CC#N.CCOC(=O)c1ccc(F)cc1.O>>CCOC(=O)c1ccc(N2CCCCC2)cc1",
        "output": "773"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)N[C@@H]1CN(C(=O)OCc2ccccc2)CC[C@H]1C1CCCCC1.Cl.[Na+].[OH-]>>N[C@@H]1CN(C(=O)OCc2ccccc2)CC[C@H]1C1CCCCC1",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOCC.CCOCC.CO.FB(F)F.O=C(c1ccc([N+](=O)[O-])c([N+](=O)[O-])c1)N1CCOCC1.[BH4-].[Na+]>>O=[N+]([O-])c1ccc(CN2CCOCC2)cc1[N+](=O)[O-]",
        "output": "215"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[O-].CCOC(C)=O.Cc1ccccc1C.Clc1c(Br)cccc1Oc1ccccc1.O.[Na+].c1ccc(Nc2ccccc2)cc1>>Clc1c(Oc2ccccc2)cccc1N(c1ccccc1)c1ccccc1",
        "output": "894"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=C1C2CCCC(CN1CCOCc1ccccc1)N2C(=O)OCc1ccccc1.[H][H].[Pd]>>O=C1C2CCCC(CN1CCOCc1ccccc1)N2",
        "output": "568"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(N)CO.CCN(C(C)C)C(C)C.CCOC(=O)Cl.ClCCl.O=C1CCC(=O)N1O>>CCOC(=O)NC(C)(C)CO",
        "output": "94"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN(C)C=O.CO[C@@H]1CN(CCO)CC[C@@H]1NC(=O)OC(C)(C)C.CS(=O)(=O)Cl>>CO[C@@H]1CN(CCOS(C)(=O)=O)CC[C@@H]1NC(=O)OC(C)(C)C",
        "output": "0"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(C)C=O.CNC1=NC(=O)C(=Cc2ccc(N3CCC(=O)CC3)cc2)S1.NC[C@H](O)COc1cccc2[nH]c(=O)[nH]c12.O=C([O-])O.[Na+].[Na+]>>CNC1=NC(=O)C(=Cc2ccc(N3CCC(NC[C@H](O)COc4cccc5[nH]c(=O)[nH]c45)CC3)cc2)S1",
        "output": "236"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.C=CC(=O)Cl.CC(C)C(C)(O)C12CC3CC(CC(O)(C3)C1)C2.CCN(CC)CC.O>>C=CC(=O)OC(C)(C(C)C)C12CC3CC(CC(O)(C3)C1)C2",
        "output": "320"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "NCCN1CCN(c2cnccn2)CC1.O=C(O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(OC(F)(F)F)cc2)cc1>>O=C(NCCN1CCN(c2cnccn2)CC1)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(OC(F)(F)F)cc2)cc1",
        "output": "835"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1nc(-n2nc(Sc3ccccn3)c3ccccc32)nc(N)c1[N+](=O)[O-].[Pd].c1ccncc1>>Nc1nc(-n2nc(Sc3ccccn3)c3ccccc32)nc(N)c1N",
        "output": "660"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C1CCNCC1.O=c1[nH]c(Cl)cc2ncccc12>>CN(C)C1CCN(c2cc3ncccc3c(=O)[nH]2)CC1",
        "output": "296"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CN(C)C=O.O.O=S(=O)(c1ccccc1)n1c(-c2ccccc2)cc2cc(Br)ccc21.[Cl-].[Li]CCCC.[NH4+]>>O=Cc1ccc2c(c1)cc(-c1ccccc1)n2S(=O)(=O)c1ccccc1",
        "output": "638"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCCC(Cc2ncn3c2CCc2cc(O)ccc2-3)C1=O.ClC(Cl)Cl.O=C([O-])O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.[Na+].c1ccncc1>>CC(C)(C)OC(=O)N1CCCC(Cc2ncn3c2CCc2cc(OS(=O)(=O)C(F)(F)F)ccc2-3)C1=O",
        "output": "731"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Clc1ccc(-c2cc(Cl)c3ccccc3n2)cc1.NC(=O)C1CCNCC1.Oc1ccccc1>>NC(=O)C1CCN(c2cc(-c3ccc(Cl)cc3)nc3ccccc23)CC1",
        "output": "398"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCc1cc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3C=O)cn(C)c2=O)no1.CO.ClCCl.[BH4-].[Na+]>>CCc1cc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3CO)cn(C)c2=O)no1",
        "output": "476"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CCOC(C)=O.Cl[Pd+].N#Cc1c(Cl)cccc1CO.NCCc1[c-]cccc1.O.O=P([O-])([O-])[O-].OB(O)c1ccccc1.[K+].[K+].[K+]>>N#Cc1c(CO)cccc1-c1ccccc1",
        "output": "892"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C=CCc1c([SiH](C)C)cc(Br)c2ccccc12.CN(C)C=O.[Cl-].[Li]C(C)(C)C.[NH4+]>>C=CCc1c([SiH](C)C)cc(C=O)c2ccccc12",
        "output": "638"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc(CBr)c(Cl)c1.ClCCl.O.O=S(=O)([O-])O.[C-]#N.[K+]>>COc1ccc(CC#N)c(Cl)c1",
        "output": "39"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "B.C1CCOC1.CSC.O=C(O)c1cc(I)ccc1O>>OCc1cc(I)ccc1O",
        "output": "72"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.OC1CC2CNC1C2.[K+].[K+]>>O=[N+]([O-])c1ccc(N2CC3CC(O)C2C3)cc1",
        "output": "26"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#Cc1cccc(N)c1.C1COCCO1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN1CCC(=O)CC1.O=C(O)C(F)(F)F.[NH4+].[Na+].[OH-]>>C#Cc1cccc(NC2CCN(C)CC2)c1",
        "output": "469"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.COC(=O)Cc1ccccc1OCc1ccc(CCc2nc(-c3ccccc3)oc2C)cc1.Cl.O.[Na+].[OH-]>>Cc1oc(-c2ccccc2)nc1CCc1ccc(COc2ccccc2CC(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)O.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.c1nc2c(c(N3CCNCC3)n1)CSC2>>CC(C)(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ncnc3c2CSC3)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.C1COCCO1.CC(C)(C)OC(=O)N1CCc2[nH]nc(C3CCOC3)c2C1.Cl>>C1Cc2[nH]nc(C3CCOC3)c2CN1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CNc1nc(-c2ccc(C#N)c(F)c2)cc(N2C[C@@H](C(=O)NC3CCCC3)CC[C@H]2C(F)(F)F)n1.NN.O>>CNc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2C[C@@H](C(=O)NC3CCCC3)CC[C@H]2C(F)(F)F)n1",
        "output": "945"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.COc1ccnc(N)c1[N+](=O)[O-].O.[Cl-].[Fe].[NH4+]>>COc1ccnc(N)c1N",
        "output": "269"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCCCCOc1ccc(Oc2sc(C(=O)OC(C)(C)C)c3c2-c2c(cnn2C)CC3)cc1.Cl>>CCOC(=O)CCCCCOc1ccc(Oc2sc(C(=O)O)c3c2-c2c(cnn2C)CC3)cc1",
        "output": "569"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "N#Cc1cc(Br)c2c(c1)cc1n2CCCNC1=O.OB(O)c1ccc(C(F)(F)F)cc1>>N#Cc1cc(-c2ccc(C(F)(F)F)cc2)c2c(c1)cc1n2CCCNC1=O",
        "output": "833"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC(Cl)Cl.CCN(CC)CC.Cl.FC1(F)CCNCC1.O=Cc1cccnc1Oc1ccc2c(nnn2CC2CC2)c1Br.[BH3-]C#N>>FC1(F)CCN(Cc2cccnc2Oc2ccc3c(nnn3CC3CC3)c2Br)CC1",
        "output": "757"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(C)=O.II.Nc1ccc(F)cn1.O=C([O-])[O-].O=S(=O)([O-])[O-].[Ag+2].[Na+].[Na+]>>Nc1ncc(F)cc1I",
        "output": "850"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C(CN1C(=O)CS(=O)(=O)C[C@H]1c1cc(F)cc(F)c1)OCc1ccccc1>>O=C(O)CN1C(=O)CS(=O)(=O)C[C@H]1c1cc(F)cc(F)c1",
        "output": "186"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC(CCOS(C)(=O)=O)(c1ccc(Cl)cc1)c1c[nH]c2c(CSC)cccc12.CS(C)=O.ClCCl.O.[C-]#N.[K+]>>CCC(CCC#N)(c1ccc(Cl)cc1)c1c[nH]c2c(CSC)cccc12",
        "output": "705"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.ClCCl.O=C(O)c1onc(-c2ccccc2)c1C(F)(F)F>>COC(=O)c1onc(-c2ccccc2)c1C(F)(F)F",
        "output": "195"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C[C@@H]1CCCN[C@@H]1CNc1nc2cc(Cl)ccc2o1.Cc1ccc(-c2nccs2)c(C(=O)O)c1>>Cc1ccc(-c2nccs2)c(C(=O)N2CCC[C@@H](C)[C@H]2CNc2nc3cc(Cl)ccc3o2)c1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(c1ccc2[nH]c(C(=O)O)cc2c1)N1CCCC1.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN1CCCC1=O.CN1CCOCC1.F[P-](F)(F)(F)(F)F.Nc1cc(F)cc(F)c1>>CC(c1ccc2[nH]c(C(=O)Nc3cc(F)cc(F)c3)cc2c1)N1CCCC1",
        "output": "548"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1noc([C@@H](C)N)n1.F[P-](F)(F)(F)(F)F.O=C(O)c1cc(-c2ccc(F)cc2)c(=O)n(-c2ccccn2)c1>>Cc1noc([C@@H](C)NC(=O)c2cc(-c3ccc(F)cc3)c(=O)n(-c3ccccn3)c2)n1",
        "output": "674"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C(O)C(C)(C)CO.N#Cc1c([N+](=O)[O-])cccc1[N+](=O)[O-]>>CC(C)C(O)C(C)(C)COc1cccc([N+](=O)[O-])c1C#N",
        "output": "499"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCCc1cccc(Br)c1.CC(C)OB(OC(C)C)OC(C)C.CCCCCCC.O.[Li]CCCC>>CC(C)(C)[Si](C)(C)OCCc1cccc(B(O)O)c1",
        "output": "832"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(Sc1nc(CC(=O)O)cs1)C(=O)O>>CC(C)(Sc1nc(CCO)cs1)C(=O)O",
        "output": "231"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CS(=O)(=O)O.Cc1ccc2c(c1)[nH]c(=O)n2CCCO.O=C([O-])[O-].O=C1NCN(c2ccccc2)C12CCNCC2.[Na+].[Na+]>>Cc1ccc2c(c1)[nH]c(=O)n2CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1",
        "output": "371"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C1CCC(=O)O1.OCc1ccc(-c2nn(Cc3ccccc3)c3ccccc23)cc1>>O=C(O)CCC(=O)OCc1ccc(-c2nn(Cc3ccccc3)c3ccccc23)cc1",
        "output": "139"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCO.CNC.Nc1ccc(S(=O)(=O)c2cc(Br)nc(Br)c2)cc1>>CN(C)c1cc(S(=O)(=O)c2ccc(N)cc2)cc(Br)n1",
        "output": "647"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)c1ccncc1.ClCCl.O=C(O)CCCCCCCCCCBr.O=[N+]([O-])c1ccccc1CO>>O=C(CCCCCCCCCCBr)OCc1ccccc1[N+](=O)[O-]",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)Cn1c(=O)n(C)c(=O)c2c(Sc3ccc([N+](=O)[O-])cc3)c(Cc3cccc4ccccc34)sc21.CCO.O.[Cl-].[Fe].[NH4+].[Na+].[OH-]>>CC(C)Cn1c(=O)n(C)c(=O)c2c(Sc3ccc(N)cc3)c(Cc3cccc4ccccc34)sc21",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN[C@@H](C)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1.COCCC(=O)O.F[P-](F)(F)(F)(F)F>>COCCC(=O)N(C)[C@@H](C)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1",
        "output": "297"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCCCC(C(=O)OC)C(C)O.[Na+].[OH-]>>C=CCCCC(C(=O)O)C(C)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.COc1ccc2c(c1)CCC(N)C2.Cl.ClCCl.O.[Na+].[OH-]>>COc1ccc2c(c1)CCC(NC(C)=O)C2",
        "output": "339"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.Cc1ccc2cc(C(N)=O)ccc2n1.ClC(Cl)Cl.O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C([O-])O.[Na+]>>Cc1ccc2cc(C#N)ccc2n1",
        "output": "374"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O.CN(C)C=O.COC(=O)c1ccc2c(c1)COc1cc([N+](=O)[O-])ccc1-2.[Zn]>>COC(=O)c1ccc2c(c1)COc1cc(N)ccc1-2",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CCN(C(C)C)C(C)C.CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)O)CC2)nc1CN1CCCC1=O.ClCCl.F[P-](F)(F)(F)(F)F.NS(=O)(=O)Cc1ccc(C(F)(F)F)cc1.O=S(=O)([O-])O.[K+]>>CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccc(C(F)(F)F)cc3)CC2)nc1CN1CCCC1=O",
        "output": "644"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O.O=C(O)c1c[nH]c2cc(Br)ccc12>>CNC(=O)c1c[nH]c2cc(Br)ccc12",
        "output": "674"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc2c(cc1F)N(C(C)=O)[C@@H](C1CC1)[C@H](C)[C@H]2Nc1nccc(C)n1.Cl.ClCCl.O.[Li+].[OH-]>>CC(=O)N1c2cc(F)c(C(=O)O)cc2[C@H](Nc2nccc(C)n2)[C@@H](C)[C@@H]1C1CC1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc2c(c1Cl)OCO2.Cl.O.O.[Li]O>>O=C(O)c1ccc2c(c1Cl)OCO2",
        "output": "222"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)C(=O)Cl.CCN(C(C)C)C(C)C.CN(C)c1ccncc1.Cl.ClCCl.NC(CO)(CO)CO.Nc1ccccc1SCc1cc(Cl)cc2c1OCOC2>>CC(C)(C)C(=O)Nc1ccccc1SCc1cc(Cl)cc2c1OCOC2",
        "output": "9"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOCc1nc2c(N)nc3ccc(OCc4ccccc4)cc3c2n1CC(C)(C)NC(=O)C1CCCCC1.[H][H].[Pd]>>CCOCc1nc2c(N)nc3ccc(O)cc3c2n1CC(C)(C)NC(=O)C1CCCCC1",
        "output": "23"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COc1cc(C(C#N)(CCCN(C)CCCOc2ccccc2[N+](=O)[O-])C(C)C)cc(OC)c1OC.O=[Pt]>>COc1cc(C(C#N)(CCCN(C)CCCOc2ccccc2N)C(C)C)cc(OC)c1OC",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCc1cccc(Br)c1.ClC(Cl)Cl.O=S(=O)(O)Cl>>CCCc1cc(Br)ccc1S(=O)(=O)Cl",
        "output": "182"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)COC1CCN(c2cc3cccnc3c(-c3cccc(C#N)c3)n2)CC1.ClCCl.O=C(O)C(F)(F)F>>N#Cc1cccc(-c2nc(N3CCC(OCC(=O)O)CC3)cc3cccnc23)c1",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1c(O)cccc1C(=O)O.O=S(=O)(O)O>>COC(=O)c1cccc(O)c1C",
        "output": "33"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCc1cnc(Cl)nc1.CS(=O)(=O)N1CC=C(c2cc3c(cn2)O[C@@H](C2CCNCC2)C3)CC1>>CCc1cnc(N2CCC([C@H]3Cc4cc(C5=CCN(S(C)(=O)=O)CC5)ncc4O3)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(B(O)O)cc1F>>O=C(c1ccc(B(O)O)cc1F)N1CCOCC1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.N.N#CCc1c2ccccc2cc2ccccc12.[NH4+].[Ni].[OH-]>>NCCc1c2ccccc2cc2ccccc12",
        "output": "246"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[O-].CN(c1cc(-c2ccccc2)nc(Cl)n1)C(C)(C)C.COC(=O)C1(c2ccc(N)cc2)CCC1.Cc1ccccc1.ClCCl.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(CCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1>>COC(=O)C1(c2ccc(Nc3nc(-c4ccccc4)cc(N(C)C(C)(C)C)n3)cc2)CCC1",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CO.COC(=O)c1ccc2c(c1)c(C)nn2Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.Cl.O.[Li+].[OH-]>>Cc1nn(Cc2ccc(-c3ccccc3C(=O)OC(C)(C)C)cc2)c2ccc(C(=O)O)cc12",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC1(C)OB(c2cnn(CCCl)c2)OC1(C)C.CN(C)C=O.CNC.[I-].[Na+]>>CN(C)CCn1cc(B2OC(C)(C)C(C)(C)O2)cn1",
        "output": "138"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC(CCCCN=[N+]=[N-])C1.CCOC(C)=O.CO.[Pd]>>CC(C)(C)OC(=O)N1CCC(CCCCN)C1",
        "output": "89"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.COC(=O)C=Cc1ccc2c(ccn2S(=O)(=O)c2ccccc2)c1.[Li+].[OH-]>>O=C(O)C=Cc1ccc2c(ccn2S(=O)(=O)c2ccccc2)c1",
        "output": "58"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(O)CCc1cccc(C(=O)c2ccccc2)c1.O=S(Cl)Cl>>O=C(Cl)CCc1cccc(C(=O)c2ccccc2)c1",
        "output": "53"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCCC1=O.N#C[Cu].Nc1ccc(Br)cc1F>>N#Cc1ccc(N)c(F)c1",
        "output": "531"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1O[C@@H]1CCCNC1.O=C(O)CO>>N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1O[C@@H]1CCCN(C(=O)CO)C1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1c2n(c3c(Br)cc(F)cc13)CCNC2=O.OB(O)c1ccc(Cl)c(C(F)(F)F)c1>>Cc1c2n(c3c(-c4ccc(Cl)c(C(F)(F)F)c4)cc(F)cc13)CCNC2=O",
        "output": "833"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O=C(O)c1ccc(O)cc1Cl.O=S(Cl)Cl>>COC(=O)c1ccc(O)cc1Cl",
        "output": "33"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COCCCn1c(C2CCCN(C(=O)OC(C)(C)C)C2)nc2ccc(OC)nc21.Cl>>COCCCn1c(C2CCCNC2)nc2ccc(OC)nc21",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1cccnc1Nc1cc(F)cc(OC)c1.O.[Li+].[OH-]>>COc1cc(F)cc(Nc2ncccc2C(=O)O)c1",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=C1Oc2cccc(O)c2C1=O.CCC(C)=O.ClCc1ccc(CCl)cc1.O=C([O-])[O-].[K+].[K+]>>CC(C)=C1Oc2cccc(OCc3ccc(CCl)cc3)c2C1=O",
        "output": "49"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN(c1cc(Cl)cc(C(=O)O)c1C)[C@@H]1CC[C@@H](N(C)C)CC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc2ccn(COCC[Si](C)(C)C)n2c(=O)c1CN.F[P-](F)(F)(F)(F)F.N#N.O>>CCN(c1cc(Cl)cc(C(=O)NCc2c(C)cc3ccn(COCC[Si](C)(C)C)n3c2=O)c1C)[C@@H]1CC[C@@H](N(C)C)CC1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COS(=O)(=O)OC.O=[N+]([O-])c1ccc(Br)c(O)c1.[Li+].[OH-]>>COc1cc([N+](=O)[O-])ccc1Br",
        "output": "317"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(C)=O.Cc1ccc(Oc2ccc([N+](=O)[O-])cc2C)cn1.[Pd]>>Cc1ccc(Oc2ccc(N)cc2C)cn1",
        "output": "335"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCNCC1CCNC1.O=C(O)c1cn(C2CCCC2)c2c(F)c(F)c(F)cc2c1=O>>CCNCC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CCCC4)c3c2F)C1",
        "output": "676"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc2nccc(Cl)c2cc1OC.O=c1c(-c2ccc(O)c(F)c2)cncn1Cc1ccc(C(F)(F)F)cc1>>COc1cc2nccc(Oc3ccc(-c4cncn(Cc5ccc(C(F)(F)F)cc5)c4=O)cc3F)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1c([C@@H]2CN3CCNC[C@H]3CN2C(=O)OC(C)(C)C)ccc(F)c1C#N.F[P-](F)(F)(F)(F)F.O=C(O)C1CCc2cc(-n3cnnn3)ncc21>>Cc1c([C@@H]2CN3CCN(C(=O)C4CCc5cc(-n6cnnn6)ncc54)C[C@H]3CN2C(=O)OC(C)(C)C)ccc(F)c1C#N",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)n1ccc2c(C(=O)OCc3ccccc3)cccc21.CO.O.[H][H].[Pd]>>CC(C)(C)OC(=O)n1ccc2c(C(=O)O)cccc21",
        "output": "290"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CS(C)=O.O.O=C([O-])[O-].O=[N+]([O-])c1cccc(F)c1.[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(c2cccc([N+](=O)[O-])c2)CC1",
        "output": "26"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(Nc2ccc(-c3ccncc3Cl)nc2)c(C(=O)OC(C)(C)C)c1.O=C(O)C(F)(F)F>>Cc1ccc(Nc2ccc(-c3ccncc3Cl)nc2)c(C(=O)O)c1",
        "output": "752"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CCN(C(C)C)C(C)C.COc1cccc2c1CC(=O)CC2.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.Cl.Cl.Cl.O.[BH3-]C#N.c1cnc(N2CCNCC2)nc1>>COc1cccc2c1CC(N1CCN(c3ncccn3)CC1)CC2",
        "output": "187"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CC1(C)CN(CCO)CCO1.COc1cc(-n2ccc3nc(-c4ccc(Cl)cc4)sc3c2=O)ccc1O.ClCCl.Oc1ccccc1.[Na+].[OH-].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc(-n2ccc3nc(-c4ccc(Cl)cc4)sc3c2=O)ccc1OCCN1CCOC(C)(C)C1",
        "output": "478"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1c(N2CCCCC2=O)nc2cc(F)cc(F)c2c1Cl.Cc1ccccc1.Nc1cc(N2CCOCC2)cnc1N1CCOCC1>>Cc1c(N2CCCCC2=O)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)cnc1N1CCOCC1",
        "output": "859"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)Cc1nc(-c2ccccc2)oc1C(C)C.CO.O.[K+].[OH-]>>CC(C)c1oc(-c2ccccc2)nc1CC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)OCCN1CCN(c2ccc(Nc3ncc4c5ccnc(Cl)c5n(C5CCCC5)c4n3)nc2)CC1.CO.Cl>>OCCN1CCN(c2ccc(Nc3ncc4c5ccnc(Cl)c5n(C5CCCC5)c4n3)nc2)CC1",
        "output": "708"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCCC(O)C(=O)OC.CCCCCCCCCCCCNCC(O)CO.[K+].[OH-]>>CCCCCCCCCCCCN(CC(O)CO)C(=O)C(O)CCCCCC",
        "output": "227"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CC(=O)OC(C)=O.COc1ccc2cccc(CCN)c2c1>>COc1ccc2cccc(CCNC(C)=O)c2c1",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CS(C)=O.Cc1c(CBr)cccc1C(F)(F)F.N#Cc1cn(-c2ccc(N3CCNC3=O)cc2)c(=O)[nH]c1=O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>Cc1c(Cn2c(=O)c(C#N)cn(-c3ccc(N4CCNC4=O)cc3)c2=O)cccc1C(F)(F)F",
        "output": "389"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc2oc(-c3cc(N)ccc3N3CCCC3)nc2c1.Cl.O=C(Cl)c1ccccc1C(F)(F)F>>Cc1ccc2oc(-c3cc(NC(=O)c4ccccc4C(F)(F)F)ccc3N3CCCC3)nc2c1",
        "output": "11"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(CO)CNC(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.c1ccncc1>>Cc1ccc(S(=O)(=O)OCC(C)(C)CNC(=O)OC(C)(C)C)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CO.C[Si](C)(C)C=[N+]=[N-].O=C(O)C1CC(F)(F)C1.c1ccccc1>>COC(=O)C1CC(F)(F)C1",
        "output": "195"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.CN1CCN(c2cncc(CC(=O)O)c2)CC1.O=C(c1ncc[nH]1)c1ncc[nH]1.[NH4+].[OH-]>>CN1CCN(c2cncc(CC(N)=O)c2)CC1",
        "output": "313"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.O=S(=O)(O)O.OCC1c2c(c3ccccc3c3ccccc23)-c2c1c1ccccc1c1ccccc21>>CC(=O)OCC1c2c(c3ccccc3c3ccccc23)-c2c1c1ccccc1c1ccccc21",
        "output": "254"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.ClCCl.NC(=O)CCc1ccc(N)cc1.O.O=C1CCC(=O)N1Br.[Cl-].[Na+]>>NC(=O)CCc1ccc(N)c(Br)c1",
        "output": "4"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCC.CN(C)C=O.CS(=O)(=O)OCC(CN1CCOC(c2cccc(C(F)(F)F)c2)C1)C(F)(F)F.[C-]#N.[Na+]>>N#CCC(CN1CCOC(c2cccc(C(F)(F)F)c2)C1)C(F)(F)F",
        "output": "705"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OCC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)[C@@H](Nc3nc(C(=O)O)cs3)[C@H]2SC1.COc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](Nc3nc(C(=O)O)cs3)[C@H]2SC1",
        "output": "228"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1c(CO)ccc2ccccc12.ClCCl>>Cc1c(CCl)ccc2ccccc12",
        "output": "713"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(Cl)cc1-c1n[nH]c(=O)c2cc(S(=O)(=O)Oc3c(F)c(F)c(F)c(F)c3F)ccc12.[Pd]>>COc1ccccc1-c1n[nH]c(=O)c2cc(S(=O)(=O)Oc3c(F)c(F)c(F)c(F)c3F)ccc12",
        "output": "253"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCC.CCOC(C)=O.CCOC(C)=O.C[C@]12CC[C@@H]3[C@H]4CCC(O)C[C@H]4CC[C@H]3[C@@H]1CCC2=O.Cc1ccc(S(=O)(=O)[O-])cc1.OCCO.c1cc[nH+]cc1.c1ccccc1>>C[C@]12CC[C@@H]3[C@H]4CCC(O)C[C@H]4CC[C@H]3[C@@H]1CCC21OCCO1",
        "output": "265"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCCCn1c(C2CCCN(C(=O)OC(C)(C)C)C2)nc2cccc(C(=O)OC)c21.ClCCl.O=C(O)C(F)(F)F>>COCCCn1c(C2CCCNC2)nc2cccc(C(=O)OC)c21",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1ccccc1C(O)CNCc1ccc(Cl)cc1Cl.CO.C[O-].Cl.[Na+]>>Nc1ccccc1C(O)CNCc1ccc(Cl)cc1Cl",
        "output": "66"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1cc2c(-c3ccc(C(F)(F)F)cc3)nc(-c3ccc(C(F)(F)F)cc3)cc2n1-c1ccc(OC(C)C)cc1.O.[Na+].[OH-]>>CC(C)Oc1ccc(-n2c(C(=O)O)cc3c(-c4ccc(C(F)(F)F)cc4)nc(-c4ccc(C(F)(F)F)cc4)cc32)cc1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COc1cc2c(Oc3cc4ccccc4nc3C)ccnc2cc1O.O.O=C([O-])[O-].OCCBr.[K+].[K+]>>COc1cc2c(Oc3cc4ccccc4nc3C)ccnc2cc1OCCO",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.N#Cc1ccc(-c2cccc3c2c2ccccc2n3-c2ccc(C(=O)O)c(NC3CCOCC3)c2)cn1.O.Oc1cccc2[nH]nnc12.[Cl-].[NH4+]>>N#Cc1ccc(-c2cccc3c2c2ccccc2n3-c2ccc(C(N)=O)c(NC3CCOCC3)c2)cn1",
        "output": "358"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.COc1ccc(C(=O)C(C)CCO)c(C)c1.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>COc1ccc(C(=O)C(C)CC=O)c(C)c1",
        "output": "142"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C=O.COc1ccc(S(=O)(=O)Cl)c([N+](=O)[O-])c1.Nc1ccc2c(c1)B(O)OC2.O>>COc1ccc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c([N+](=O)[O-])c1",
        "output": "68"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C[C@H]1CN(CCC2(O)CCC(N)CC2)CC[C@@H]1O.O=C(O)c1cc2c(OCc3coc4c3C(=O)CCC4)cccc2[nH]1>>C[C@H]1CN(CCC2(O)CCC(NC(=O)c3cc4c(OCc5coc6c5C(=O)CCC6)cccc4[nH]3)CC2)CC[C@@H]1O",
        "output": "137"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.Cc1cccc(C)n1.ClCCl.O=C1O[C@H]2[C@H](O)CC[C@H]2N1S(=O)(=O)c1ccccc1[N+](=O)[O-]>>CC(C)(C)[Si](C)(C)O[C@@H]1CC[C@@H]2[C@H]1OC(=O)N2S(=O)(=O)c1ccccc1[N+](=O)[O-]",
        "output": "839"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CN(C)c1ccc(CO)cc1.O=Cc1cccc(O)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN(C)c1ccc(COc2cccc(C=O)c2)cc1",
        "output": "347"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCCCCCCCCC(=O)CCCCCCCCC.CCOC(OCC)OCC.CN(C)C=O.Cl.ClCCl.O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1>>CCCCCCCCCC1(CCCCCCCCC)O[C@@H]2[C@@H](CO)O[C@@H](n3ccc(=O)[nH]c3=O)[C@@H]2O1",
        "output": "265"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCC1CO1.O.O=[N+]([O-])c1ccc(O)cc1.[Na+].[OH-]>>O=[N+]([O-])c1ccc(OCC2CO2)cc1",
        "output": "15"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CCN.CCO.O=c1c(Cl)nc2cccnc2n1-c1ccc(Cl)cc1>>CCN(CC)CCNc1nc2cccnc2n(-c2ccc(Cl)cc2)c1=O",
        "output": "148"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COC(=O)CCCBr.Clc1ccc(Oc2ccc(O[C@@H]3CCNC3)cc2)cc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)CCCN1CC[C@@H](Oc2ccc(Oc3ccc(Cl)cc3)cc2)C1",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NCCC(N)c1ccccc1.CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O.O=C(O)c1ccc(Cl)c(NC(=O)c2cc3cncnc3[nH]c2=O)c1>>CC(C)(C)OC(=O)NCCC(NC(=O)c1ccc(Cl)c(NC(=O)c2cc3cncnc3[nH]c2=O)c1)c1ccccc1",
        "output": "753"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(OCc2ccccc2)c(Br)cc1C(C)=O.NN.O.OCCOCCOCCO.[Na+].[OH-]>>CCc1cc(Br)c(OCc2ccccc2)cc1OC",
        "output": "92"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(O)c1ccccc1Br.c1ccc(-c2ccnc(N3CC4CNCC4C3)n2)cc1>>O=C(c1ccccc1Br)N1CC2CN(c3nccc(-c4ccccc4)n3)CC2C1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1cc(Oc2nc3cc(C#Cc4ccccc4F)c(Cl)cc3[nH]2)ccc1C.O.[Na+].[OH-]>>Cc1ccc(Oc2nc3cc(C#Cc4ccccc4F)c(Cl)cc3[nH]2)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1ccncc1.O=C(O)c1cc(NC2CCCCC2)ncn1>>O=C(Nc1ccncc1)c1cc(NC2CCCCC2)ncn1",
        "output": "548"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)CCCCCCCN.Cl.Cl.O.O=C1Nc2ccc(F)cc2C1=Cc1cccc(C(=O)O)c1.Oc1cccc2[nH]nnc12.[Cl-].[Na+]>>COC(=O)CCCCCCCNC(=O)c1cccc(C=C2C(=O)Nc3ccc(F)cc32)c1",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.COc1ccccc1C=O.O.[Na+].[OH-]>>COc1ccccc1C=CC(C)=O",
        "output": "295"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.NNc1cc(N2CCOCC2)n2nc(-c3ccccc3)cc2n1.O=C(O)C(F)(F)F.O=Cc1ccc(O)cc1>>Oc1ccc(C=NNc2cc(N3CCOCC3)n3nc(-c4ccccc4)cc3n2)cc1",
        "output": "167"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.CCI.Nc1ncccc1C(=O)O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cccnc1N",
        "output": "196"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.ClCCl.Fc1cc(Cl)ccc1OC1CCNCC1.N#Cc1ccc2nc(Cl)c(Cl)nc2c1.O>>N#Cc1ccc2nc(N3CCC(Oc4ccc(Cl)cc4F)CC3)c(Cl)nc2c1",
        "output": "505"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=CCBr.CN(C)C=O.Cc1ccc(O)cc1.O.[Na+].[OH-]>>CC(C)=CCOc1ccc(C)cc1",
        "output": "77"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.COC(=O)c1cc(C)c(-c2cnc(OC)c(-c3cnc(S(C)(=O)=O)nc3CN3C(=O)O[C@H](c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H]3C)c2)c(C)c1.Cl.FC1CNC1>>COC(=O)c1cc(C)c(-c2cnc(OC)c(-c3cnc(N4CC(F)C4)nc3CN3C(=O)O[C@H](c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H]3C)c2)c(C)c1",
        "output": "679"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(CCN)c(Cl)c1.O=C(O)Cn1nnc2ccccc2c1=O>>COc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)c(Cl)c1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCn1c2ccccc2c2ccccc21.O.O=[N+]([O-])O>>CCn1c2ccccc2c2cc([N+](=O)[O-])ccc21",
        "output": "21"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC1(C)OB(c2cccc(N)c2)OC1(C)C.CCN(CC)CC.CCN=C=O.CCOCC>>CCNC(=O)Nc1cccc(B2OC(C)(C)C(C)(C)O2)c1",
        "output": "176"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)c1ccncc1.CN1C(C)(C)CN(c2cc(F)ccc2CN)S1(=O)=O.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1nc2n(c(=O)c1OCc1ccccc1)CC1CCN2CC1>>CN1C(C)(C)CN(c2cc(F)ccc2CNC(=O)c2nc3n(c(=O)c2OCc2ccccc2)CC2CCN3CC2)S1(=O)=O",
        "output": "905"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cc1ccc(-c2cc(C(=O)O)cc(C(=O)N(C)CC(C)C)c2)cc1.Cl.ClCCl.NCc1ccn2ccnc2c1.O.On1nnc2ccccc21>>Cc1ccc(-c2cc(C(=O)NCc3ccn4ccnc4c3)cc(C(=O)N(C)CC(C)C)c2)cc1",
        "output": "836"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cn(CCCNC(=O)c2ccc(C(F)(F)F)cc2OC)nn1.[Na+].[OH-]>>COc1cc(C(F)(F)F)ccc1C(=O)NCCCn1cc(C(=O)O)nn1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)Nc1ccc2cc([N+](=O)[O-])ccc2n1.CO.ClCCl>>CC(C)Nc1ccc2cc(N)ccc2n1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCOc1nc(Cc2ccc(Cl)cc2)nc2oc(-c3cc(C)c(OCC(=O)OC(C)(C)C)c(C)c3)nc12.O.O=C(O)C(F)(F)F>>CCCOc1nc(Cc2ccc(Cl)cc2)nc2oc(-c3cc(C)c(OCC(=O)O)c(C)c3)nc12",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.C[Si](C)(C)C=[N+]=[N-].Cc1ccc(Br)c(C(=O)O)c1>>COC(=O)c1cc(C)ccc1Br",
        "output": "33"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.COCCN(Cc1ccc(-c2cc3nccc(Oc4ccc(NC(=S)NC5CC5)cc4F)c3s2)nc1)C(=O)OC(C)(C)C.Cl.O.[Na+].[OH-]>>COCCNCc1ccc(-c2cc3nccc(Oc4ccc(NC(=S)NC5CC5)cc4F)c3s2)nc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1.O.O=C(O)C(F)(F)F.O=C(O)c1ccc(C(=O)c2ccccc2)cc1.On1nnc2ccccc21>>O=C(NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1)c1ccc(C(=O)c2ccccc2)cc1",
        "output": "718"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(=O)O.CCI.Cl.O.[Cl-].[H-].[Na+].[Na+]>>CCO[C@@H]1C[C@@H](C(=O)O)N(C(=O)OC(C)(C)C)C1",
        "output": "307"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.Br.CC(=O)O.CC(C)O.CCOC(=O)c1c(O)c2c(C)csc2n(C)c1=O>>Cc1csc2c1c(O)c(C(=O)O)c(=O)n2C",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1=COCCC1.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.O=C(Cc1cc(F)cc(F)c1)c1cc(O)ccc1O.c1cc[nH+]cc1>>O=C(Cc1cc(F)cc(F)c1)c1cc(OC2CCCCO2)ccc1O",
        "output": "319"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=C[C@H]1CNCC[C@H]1CCc1c[nH]c2ccccc12.CO.Cl.O=[Pt]>>CC[C@H]1CNCC[C@H]1CCc1c[nH]c2ccccc12",
        "output": "116"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CO.COc1cc(-c2ccnc3nc(C(F)(F)F)ccc23)ccc1F.ClCCl.O=C([O-])O.[Na+]>>Oc1cc(-c2ccnc3nc(C(F)(F)F)ccc23)ccc1F",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)CCNC(=O)c1nc(-c2ccccc2)oc1C(F)(F)F.O.[Na+].[OH-]>>O=C(O)CCNC(=O)c1nc(-c2ccccc2)oc1C(F)(F)F",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.ClCCl.N.N#CC[C@@H](O)c1cccc(OCC2CCCC2)n1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCC[C@@H](O)c1cccc(OCC2CCCC2)n1",
        "output": "246"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)NCCO.ClCCl.O=C(O)C(F)(F)F>>N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)NCCO",
        "output": "431"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.Nc1ccc(S(=O)(=O)C[N+](=O)[O-])cc1.O=C(Cl)c1ccccc1>>O=C(Nc1ccc(S(=O)(=O)C[N+](=O)[O-])cc1)c1ccccc1",
        "output": "11"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)O.ClCCl.ClCCl.O=C(CNc1noc2ccc(C(F)(F)F)cc12)NC1CNC1.O=C1CCC(c2ccc3c(c2)OCO3)CC1.[Na+]>>O=C(CNc1noc2ccc(C(F)(F)F)cc12)NC1CN(C2CCC(c3ccc4c(c3)OCO4)CC2)C1",
        "output": "187"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[C@H](N)CO.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1nn(-c2cc(Br)ccn2)c2c1C[C@H]1C[C@@H]21>>CC(C)(C)[C@@H](CO)NC(=O)c1nn(-c2cc(Br)ccn2)c2c1C[C@H]1C[C@@H]21",
        "output": "816"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.ClCCCl.N.O.O=C(O)Cn1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nc1-c1ccccc1Cl.On1nnc2ccccc21>>NC(=O)Cn1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nc1-c1ccccc1Cl",
        "output": "313"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CI.CN(C)C=O.O=C([O-])[O-].O=c1[nH]cc(-c2cccc(-c3ccccc3)c2)c(F)c1OCc1ccccc1.[Cs+].[Cs+]>>Cn1cc(-c2cccc(-c3ccccc3)c2)c(F)c(OCc2ccccc2)c1=O",
        "output": "191"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(-c2cccc(O)c2)n1C.ClCC1CO1.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(-c2cccc(OCC3CO3)c2)n1C",
        "output": "15"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Clc1ncccn1.OCCOc1ccc(Cn2cccn2)cc1.[H-].[Na+]>>c1cnc(OCCOc2ccc(Cn3cccn3)cc2)nc1",
        "output": "37"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1ccc(OCC(F)(F)F)nc1OC.Cl.O.[Na+].[OH-]>>COc1nc(OCC(F)(F)F)ccc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)[O-].CCCCN(CCCC)CCCN.Cl.O=[N+]([O-])c1ccccc1Br.[Na+]>>CCCCN(CCCC)CCCNc1ccccc1[N+](=O)[O-]",
        "output": "519"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.Cc1cc(OCCCO)cc(OS(=O)(=O)c2cccc3cnccc23)c1.ClCCl>>Cc1cc(OCCC=O)cc(OS(=O)(=O)c2cccc3cnccc23)c1",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)Oc1cccc(C(=O)O)c1.CC(C)Oc1cccc(N=C=O)c1.Cn1c(CO)c(-c2ccccc2)c2cc(Cl)ccc2c1=O.c1ccccc1>>CC(C)Oc1cccc(NC(=O)OCc2c(-c3ccccc3)c3cc(Cl)ccc3c(=O)n2C)c1",
        "output": "34"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.O=S([O-])S(=O)[O-].O=[N+]([O-])c1ccc(Br)cc1O.[Na+].[Na+].[Na+].[OH-]>>Nc1ccc(Br)cc1O",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(Nc2cc3ccccc3c(Cl)n2)n[nH]1.Oc1ccc(Cl)cc1>>Cc1cc(Nc2cc3ccccc3c(Oc3ccc(Cl)cc3)n2)n[nH]1",
        "output": "516"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Cc1ccc2[nH]c3c(c2c1)CCN(C)CC3.Clc1ccccc1CCBr.I[Cu]I.O.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>Cc1ccc2c(c1)c1c(n2CCc2ccccc2Cl)CCN(C)CC1",
        "output": "470"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)CC(CCc1ccccc1)C(=O)O.CN1CCOCC1.ClCCCl.NCCc1c[nH]c2ccccc12.On1nnc2ccccc21>>CCOC(=O)CC(CCc1ccccc1)C(=O)NCCc1c[nH]c2ccccc12",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CC(=O)OC(C)Cc1ccccc1.CC(Cl)Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)OC(C)Cc1ccc(C(C)=O)cc1",
        "output": "31"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OCc1nnnn1-c1ccc(C(F)(F)F)cn1.CCO.O.[Li+].[OH-]>>OCc1nnnn1-c1ccc(C(F)(F)F)cn1",
        "output": "348"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cc1nn(C)c(-c2c(F)cc(O)cc2F)c1C(=O)c1ccc(F)cc1Cl.ICC1CC1.O.O=C([O-])[O-].[K+].[K+]>>Cc1nn(C)c(-c2c(F)cc(OCC3CC3)cc2F)c1C(=O)c1ccc(F)cc1Cl",
        "output": "198"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(C)(C)C.O.O=C(O)Cc1c[nH]c2ccccc12.O=C([O-])[O-].O=S(=O)(O)O.[K+].[K+].[Na+].[OH-]>>COC(=O)Cc1c[nH]c2ccccc12",
        "output": "195"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.ClCCl.Fc1ccc(CBr)cc1.[Br-].[Na+].[OH-].c1cc[nH]c1>>Fc1ccc(Cn2cccc2)cc1",
        "output": "528"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC#N.COC(=O)c1ccc(CN(Cc2ccccn2)S(=O)(=O)c2ccc(Cl)cc2)cc1.O.[Na+].[OH-]>>O=C(O)c1ccc(CN(Cc2ccccn2)S(=O)(=O)c2ccc(Cl)cc2)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.N#Cc1ccc(C(=O)O)cc1.NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1.O.O=C(O)C(F)(F)F.On1nnc2ccccc21>>N#Cc1ccc(C(=O)NCC(=O)N2CCN(C(=O)c3ccccc3C(F)(F)F)CC2)cc1",
        "output": "718"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2oc3ccc(OCC4CC4)cc3c2C)C(C)C)cc1.[Na+].[OH-]>>Cc1c(C(Nc2ccc(C(=O)N(C)CCC(=O)O)cc2)C(C)C)oc2ccc(OCC3CC3)cc12",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCN(Cc1ccc(COc2ccc3c(c2)CCC3CC(=O)OCC)cc1)c1nc(-c2ccccc2)cs1.CCO.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>CCCN(Cc1ccc(COc2ccc3c(c2)CCC3CC(=O)O)cc1)c1nc(-c2ccccc2)cs1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Nc1ncc(Br)cc1OCc1ccccc1C(F)(F)F.O.O=C(O)c1ccc(B(O)O)cc1.O=C([O-])[O-].[K+].[K+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Nc1ncc(-c2ccc(C(=O)O)cc2)cc1OCc1ccccc1C(F)(F)F",
        "output": "833"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN(C)C=O.CNCC(F)(F)F.Cl.N#Cc1c(Cl)nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c1-c1ccc(OCCO)cc1.O>>CN(CC(F)(F)F)c1nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c(-c2ccc(OCCO)cc2)c1C#N",
        "output": "220"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Clc1cncc(Cl)n1.OCCc1cccnc1.[H-].[Na+]>>Clc1cncc(OCCc2cccnc2)n1",
        "output": "209"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCC(CCOc1ccc(OCC(=O)OCC)c(C)c1)c1sc2cc(F)ccc2c1C.CO.[Na+].[OH-]>>CCCCC(CCOc1ccc(OCC(=O)O)c(C)c1)c1sc2cc(F)ccc2c1C",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1cccc(C)c1OC.[Na+].[OH-]>>COc1c(C)cccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccccc1.CO.O=C([O-])[O-].Oc1ccc(O)c(Br)c1.[Cl-].[K+].[K+].[NH4+]>>Oc1ccc(OCc2ccccc2)c(Br)c1",
        "output": "127"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COc1cc2oc(=O)c3c(c2cc1OCCCOS(C)(=O)=O)CCC3.Fc1ccc(N2CCNCC2)cc1.O=C([O-])/C=C/C(=O)[O-]>>COc1cc2oc(=O)c3c(c2cc1OCCCN1CCN(c2ccc(F)cc2)CC1)CCC3",
        "output": "496"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CCSCc1cccc(C(=O)O)c1.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl.Nc1ccc(OC2CCOCC2)cc1-c1cc(C(=O)NCc2cccc(C(F)(F)F)c2)ccn1>>CC(C)(C)OC(=O)CCSCc1cccc(C(=O)Nc2ccc(OC3CCOCC3)cc2-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1",
        "output": "817"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1cc2cc[nH]c2cc1F.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>COc1cc2c(C=O)c[nH]c2cc1F",
        "output": "266"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.O.O=C(c1ccncc1)c1ccccc1[N+](=O)[O-].[Na+].[OH-]>>Nc1ccccc1C(=O)c1ccncc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)c1cc(F)ccn1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1cc(F)ccn1",
        "output": "546"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C(O)c1cn(C2CC2)c2cc(N3CCC(COc4ccc(N5C[C@H](CO)OC5=O)cc4F)CC3)c(F)cc2c1=O.O=C([O-])[O-].[K+].[K+]>>O=C(OCc1ccccc1)c1cn(C2CC2)c2cc(N3CCC(COc4ccc(N5C[C@H](CO)OC5=O)cc4F)CC3)c(F)cc2c1=O",
        "output": "403"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.CNCc1cc2ccsc2s1.ClCCCl.Nc1ccc(/C=C/C(=O)O)cn1.O.On1nnc2ccccc21>>CN(Cc1cc2ccsc2s1)C(=O)/C=C/c1ccc(N)nc1",
        "output": "811"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCCCC.FC(F)(F)c1ccc(CBr)cc1.OCCO.[Cl-].[H-].[H][H].[NH4+].[Na+]>>OCCOCc1ccc(C(F)(F)F)cc1",
        "output": "464"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CN.N#Cc1ccc(CS(=O)(=O)Cl)cc1>>CNS(=O)(=O)Cc1ccc(C#N)cc1",
        "output": "493"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)C1CN(C(=O)OC(C)(C)C)c2cc(Cl)c(Cl)cc2O1.O.O.[Li]O>>CC(C)(C)OC(=O)N1CC(C(=O)O)Oc2cc(Cl)c(Cl)cc21",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN[C@H](C)c1ccccc1.Cc1noc(-c2ccc(Br)cc2)c1C1CC1C(=O)O>>Cc1noc(-c2ccc(Br)cc2)c1C1CC1C(=O)N(C)[C@H](C)c1ccccc1",
        "output": "633"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)COc1c(OC)cc(Cc2cnc(N)nc2N)cc1OC.O.[Li+].[OH-]>>COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)NC(=O)[C@H]1CC[C@@H](Nc2cc(Cl)ncc2[N+](=O)[O-])CC1.CN1CCC(O)CC1>>CC(C)NC(=O)[C@@H]1CC[C@H](Nc2cc(OC3CCN(C)CC3)ncc2[N+](=O)[O-])CC1",
        "output": "433"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.Cl.O=[N+]([O-])c1cc(C(F)(F)C(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)c2ccc(O)c([N+](=O)[O-])c2)ccc1O.[H][H].[Pd]>>Nc1cc(C(F)(F)C(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)c2ccc(O)c(N)c2)ccc1O",
        "output": "204"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COCC1CN(Cc2ccccc2)CCN1C(=O)C(F)(F)F.[H][H].[Pd]>>COCC1CNCCN1C(=O)C(F)(F)F",
        "output": "84"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCCCC=CCCCNc1ccccc1C(=O)Cl.CCN(CC)CC.Cl.ClCCl.Oc1ccc(Cl)cc1>>CCCCCCCCCC=CCCCNc1ccccc1C(=O)Oc1ccc(Cl)cc1",
        "output": "482"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)C(=O)N[C@H]1C[C@@H]2c3cc(C=O)cc4[nH]cc(c34)C[C@H]2N(C)C1.Cl.N.O=C(O)C(O)C(O)C(=O)O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCN(CC)C(=O)N[C@H]1C[C@@H]2c3cc(CO)cc4[nH]cc(c34)C[C@H]2N(C)C1",
        "output": "356"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.Cn1nc(-c2cccc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(Nc2ccc(N3CC4(CN(C(=O)OC(C)(C)C)C4)C3)cn2)c1=O.O=C(O)C(F)(F)F>>Cn1nc(-c2cccc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(Nc2ccc(N3CC4(CNC4)C3)cn2)c1=O",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCC(=O)Cl.CCN(CC)CC.ClCCl.Nc1c(Cl)nc2ccccc2c1NCC1(O)CCSCC1.O=C([O-])O.[Na+]>>CCCC(=O)Nc1c(Cl)nc2ccccc2c1NCC1(O)CCSCC1",
        "output": "422"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)C=Cc1ccc(O)cc1C=O.CCO.Cl.NO.c1ccncc1>>CC(C)(C)OC(=O)C=Cc1ccc(O)cc1C=NO",
        "output": "30"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCON.Cl.O=C(NC(Cc1ccccc1)C(O)C(=O)O)c1cccnc1-n1ccc(-c2ccccc2)n1>>CCONC(=O)C(O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1",
        "output": "480"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CI.CN(C)C=O.O=C1Cc2ccccc2CCN1.[H-].[Na+]>>CN1CCc2ccccc2CC1=O",
        "output": "83"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(Br)c1.OB(O)c1cncc(F)c1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncc(F)c2)c1",
        "output": "883"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.Nc1cccc(NC(=O)C(F)(F)F)c1.O=C=Nc1ccc(Cl)c(Cl)c1>>O=C(Nc1cccc(NC(=O)C(F)(F)F)c1)Nc1ccc(Cl)c(Cl)c1",
        "output": "473"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClC(Cl)Cl.N[C@@H]1CN(C(=O)OCc2ccccc2)C[C@H]1O>>CC(C)(C)OC(=O)N[C@@H]1CN(C(=O)OCc2ccccc2)C[C@H]1O",
        "output": "631"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCNCc1ccccn1.COc1ccc(N(CC(=O)O)S(=O)(=O)c2ccccc2C)cn1>>CCN(Cc1ccccn1)C(=O)CN(c1ccc(OC)nc1)S(=O)(=O)c1ccccc1C",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "N#CCCCCCCCCN.O=S(=O)(Cl)c1ccccc1.c1ccncc1>>N#CCCCCCCCCNS(=O)(=O)c1ccccc1",
        "output": "43"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)c1cc(C)nn1-c1ccc2onc(N)c2c1.[Na+].[OH-]>>Cc1cc(C(=O)O)n(-c2ccc3onc(N)c3c2)n1",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(Cl)Cl.CCO.CN(C)C=O.O=C(Cl)C(=O)Cl.O=C(O)c1cc(Br)cc2nc[nH]c12>>CCOC(=O)c1cc(Br)cc2nc[nH]c12",
        "output": "47"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cl.Cl.N[C@H]1CN2CCC1CC2.O.O=C(O)c1ccc(Br)o1.On1nnc2ccccc21>>O=C(N[C@H]1CN2CCC1CC2)c1ccc(Br)o1",
        "output": "714"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)O.COC(=O)c1cccc(S(C)(=O)=NC(=O)c2cncc(C#Cc3cccc(NC(=O)c4cc(C)nn4C)c3)c2)c1.[Na+].[OH-]>>Cc1cc(C(=O)Nc2cccc(C#Cc3cncc(C(=O)N=S(C)(=O)c4cccc(C(=O)O)c4)c3)c2)n(C)n1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.COc1cc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)ccn1.Cl.O.c1cc[nH+]cc1>>O=C(NCc1cc[nH]c(=O)c1)c1cccc2c1cnn2-c1ccc(F)cc1",
        "output": "758"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cc1cc(O)ccc1CCCCn1ccnn1.ClCc1cccc(-c2ccc(Cl)cc2)n1.O.[H-].[Na+]>>Cc1cc(OCc2cccc(-c3ccc(Cl)cc3)n2)ccc1CCCCn1ccnn1",
        "output": "616"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.Nc1ccc(N2N=C3c4cc(Cl)ccc4CCC3CC2=O)cc1>>CC(=O)Nc1ccc(N2N=C3c4cc(Cl)ccc4CCC3CC2=O)cc1",
        "output": "6"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC(=O)O.CCC(=O)OC(=O)CC.NS(=O)(=O)c1ccc(-c2cc(-c3nc(-c4ccc(C(F)(F)F)cc4)cc(C(F)(F)F)n3)ccn2)s1.O=C([O-])O.[Na+]>>CCC(=O)NS(=O)(=O)c1ccc(-c2cc(-c3nc(-c4ccc(C(F)(F)F)cc4)cc(C(F)(F)F)n3)ccn2)s1",
        "output": "801"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)C(=O)Cl.CCN(CC)CC.CN(C)c1ccncc1.O=[N+]([O-])c1ccc2nc(-c3ccccc3)cc(O)c2c1>>CCN(CC)C(=O)Oc1cc(-c2ccccc2)nc2ccc([N+](=O)[O-])cc12",
        "output": "425"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)c1cc(NC(=O)N2CCCNCC2)no1.CCc1cnc(Cl)nc1.CN1CCCC1=O.O=C([O-])[O-].[Cu].[K+].[K+]>>CCc1cnc(N2CCCN(C(=O)Nc3cc(C(C)(C)C)on3)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)Cl.CCOC(=O)Oc1cc(C=C(C#N)C(=O)OCCc2ccccc2)ccc1O>>CCOC(=O)Oc1ccc(C=C(C#N)C(=O)OCCc2ccccc2)cc1OC(=O)OCC",
        "output": "261"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCn1cc(-c2ccc(Cl)cc2Cl)nc1/C=C/c1cccc(Br)c1.OB(O)c1ccc(O)cc1>>CCn1cc(-c2ccc(Cl)cc2Cl)nc1/C=C/c1cccc(-c2ccc(O)cc2)c1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CO.COC1CCN(c2nccc(Nc3cc(NC(C)C)c([N+](=O)[O-])cn3)n2)CC1.[Pd]>>COC1CCN(c2nccc(Nc3cc(NC(C)C)c(N)cn3)n2)CC1",
        "output": "269"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.O=c1c2c(oc3ccc(Br)cc13)CCC(O)C2.c1ccncc1>>CC(=O)OC1CCc2oc3ccc(Br)cc3c(=O)c2C1",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.N#Cc1cccc(N=C=O)c1.NCCCN1CCC(Cc2ccccc2)CC1>>N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1",
        "output": "35"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cnc(-c2cc3ccc(O)cc3oc2=O)s1.O=S(=O)(O)O>>O=C(O)c1cnc(-c2cc3ccc(O)cc3oc2=O)s1",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.CC(=O)c1ccc(S(F)(F)(F)(F)F)cc1N.CCN(CC)CC.ClCCl.O.O=C([O-])O.[Na+]>>CC(=O)Nc1cc(S(F)(F)(F)(F)F)ccc1C(C)=O",
        "output": "9"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCCC/C=C/COc1ccc(C(=O)Nc2ccccc2Sc2ccccc2C(N)=O)cc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CCCC/C=C/COc1ccc(C(=O)Nc2ccccc2Sc2ccccc2C#N)cc1",
        "output": "374"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Cl.N#Cc1ccccc1CBr.O=C([O-])[O-].O=C1CCNCC1C(c1ccc(F)cc1)c1ccc(F)cc1.[K+].[K+]>>N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1",
        "output": "248"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCP(CCCC)CCCC.CCOc1cc(-c2ccccc2)nn1CCO.Cc1ccccc1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.O=Cc1ccc(O)c(Cl)c1>>CCOc1cc(-c2ccccc2)nn1CCOc1ccc(C=O)cc1Cl",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCCCC.CN(C)C=O.N#Cc1cc2cc(CO)[nH]c2cc1Cl.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCc1cc2cc(C#N)c(Cl)cc2[nH]1",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1c2cc(Cl)nc(=O)n2CC1(C)C.OCCc1cc(F)cc(F)c1>>CN1c2cc(OCCc3cc(F)cc(F)c3)nc(=O)n2CC1(C)C",
        "output": "653"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cc1ccccc1.Cn1c(CN2CCC(c3ccccc3F)CC2)nc2ccc(Br)cc21.O=C([O-])O.OB(O)c1ccccc1.[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cn1c(CN2CCC(c3ccccc3F)CC2)nc2ccc(-c3ccccc3)cc21",
        "output": "909"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)COc1ccc2cc(Br)ccc2c1.Cc1ccc(OCC(=O)O)cc1.[Na+].[OH-]>>O=C(O)COc1ccc2cc(Br)ccc2c1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1ccc([N+](=O)[O-])cc1N.O=C(O)C1CC1>>O=[N+]([O-])c1ccc2[nH]c(C3CC3)nc2c1",
        "output": "512"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CCCc1[nH]c2cc(C(=O)O)ccc2c1C(=O)C(C)C.CN(C)c1ccncc1.OCc1ccccc1>>CCCc1[nH]c2cc(C(=O)OCc3ccccc3)ccc2c1C(=O)C(C)C",
        "output": "33"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.Clc1ccc(C(OC2CNC2)c2ccc(Cl)cc2)cc1.O=C(Cl)C1CCCC1.O=C(c1sccc1Cl)N1CC(OC(c2ccc(Cl)cc2)c2ccccc2Cl)C1>>O=C(C1CCCC1)N1CC(OC(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.O.O=C([O-])c1cnc2cc(-c3cccs3)ccc2c1.[H-]>>OCc1cnc2cc(-c3cccs3)ccc2c1",
        "output": "293"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Cc1ccc(N)cc1C1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(Cl)OCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>Cc1ccc(NC(=O)OCc2ccccc2)cc1C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "509"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC2=NCCCN2CC1.CC(C)S(=O)(=O)Cl.ClCCl.N[C@@H]1CCCO[C@H]1c1ccc(Br)cc1.O>>CC(C)S(=O)(=O)N[C@@H]1CCCO[C@H]1c1ccc(Br)cc1",
        "output": "493"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOc1ccccc1-c1ccc(CN)cc1N>>CCOc1ccccc1-c1ccc(CNC(=O)OC(C)(C)C)cc1N",
        "output": "686"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.OCc1cnc(C(F)(F)F)c(Br)c1>>O=Cc1cnc(C(F)(F)F)c(Br)c1",
        "output": "520"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)COCC1OCCN(C(=O)OC(C)(C)C)CC1c1ccc(Cl)c(Cl)c1.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[Al+3].[Cl-].[Cl-].[Cl-].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCOC(COCCO)C(c2ccc(Cl)c(Cl)c2)C1",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)OC(C)(C)C.[Li+].[OH-]>>CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[C@H](N)CO.CCN(CC)CC.ClCCl.O=S(=O)(Cl)c1ccc(Cl)cc1>>CC(C)(C)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)cc1",
        "output": "43"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc2ncnc(Cl)c2cc1OC.O=C(Nc1ccc2cc(O)ccc2c1)OCc1ccccc1>>COc1cc2ncnc(Oc3ccc4cc(NC(=O)OCc5ccccc5)ccc4c3)c2cc1OC",
        "output": "890"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CN(C)C=O.COc1c(Br)ccc(CS(=O)(=O)c2ccccc2)c1C(=O)O.O=C([O-])[O-].O=[Cu].[Cs+].[Cs+].c1cn[nH]c1>>COc1c(-n2cccn2)ccc(CS(=O)(=O)c2ccccc2)c1C(=O)O",
        "output": "919"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCS(N)(=O)=O.Cc1ccccc1Nc1c(C(=O)N2CCC(C)(c3ccccc3)CC2)cnc2c(C(=O)O)cnn12>>CCS(=O)(=O)NC(=O)c1cnn2c(Nc3ccccc3C)c(C(=O)N3CCC(C)(c4ccccc4)CC3)cnc12",
        "output": "991"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrBr.CC(=O)c1ccc(-c2ccc(Br)cc2)cc1.ClCCl>>O=C(CBr)c1ccc(-c2ccc(Br)cc2)cc1",
        "output": "173"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC1CC(=O)CC(C)(C)C1O.CO.N.[H][H].[NH4+].[Ni]>>CC1CC(N)CC(C)(C)C1O",
        "output": "63"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COCCBr.COc1cc2c(OC(C)C)nc(Nc3cc(C)[nH]n3)cc2cc1O>>COCCOc1cc2cc(Nc3cc(C)[nH]n3)nc(OC(C)C)c2cc1OC",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.CC1=C(C)C(=O)N(CCO)C1=O.O=S(=O)(O)O>>CC(=O)OCCN1C(=O)C(C)=C(C)C1=O",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(NC(=O)c1cc(N)ncn1)c1ccc(OCC(F)(F)F)nc1.CCC(=O)Cl>>CCC(=O)Nc1cc(C(=O)NC(C)c2ccc(OCC(F)(F)F)nc2)ncn1",
        "output": "332"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C[C@@H]1CCCN1.Cc1ccccc1.N#Cc1ccc(-c2ccc3cc(CCCl)nnc3c2)cc1.O.O=C(O)[C@H](O)[C@@H](O)C(=O)O.[Cl-].[Na+].[Na+].[OH-]>>C[C@@H]1CCCN1CCc1cc2ccc(-c3ccc(C#N)cc3)cc2nn1",
        "output": "138"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCCS.N#Cc1cccc(Cl)n1.[H-].[Na+]>>CCCCCSc1cccc(C#N)n1",
        "output": "333"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.COc1ccc(C(C)C)cc1CO.Cl.ClCCl.O=C([O-])O.O=C1CCNCC1C(c1ccccc1)c1ccccc1.[Na+]>>COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1",
        "output": "765"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)c1ncc(-c2cccc([N+](=O)[O-])c2)s1.CCOC(C)=O.ClCCl.[Pd]>>CC(C)(CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)c1ncc(-c2cccc(N)c2)s1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.Cn1cc(-c2ccc(-c3cncc4ccc(C(=O)N5CCN(C(=O)OC(C)(C)C)CC5)nc34)cc2)cn1.O=C(O)C(F)(F)F>>Cn1cc(-c2ccc(-c3cncc4ccc(C(=O)N5CCNCC5)nc34)cc2)cn1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)NCc1nc2c(c(=O)[nH]1)COCC2.O=C(O)CN1CCC(C(=O)c2ccc(F)cc2)CC1>>CC(C)N(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CN2CCN1CC2.CCOC(C)=O.CN(C)C=O.Cl.N#CCc1ccc(O)cc1.c1ccc(OCC2CO2)cc1>>N#CCc1ccc(OCC(O)COc2ccccc2)cc1",
        "output": "277"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CON.Cl.O=C(Cc1cccnc1)c1ccc(Cl)cc1Cl.O=C([O-])[O-].[Na+].[Na+]>>CON=C(Cc1cccnc1)c1ccc(Cl)cc1Cl",
        "output": "212"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCNC(=O)NOCC(=O)O.CCOC(OCC)[C@H](C)N(Cc1csc2ccccc12)C(=O)[C@@H](N)CC(=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1>>CCNC(=O)NOCC(=O)N[C@@H](CC(=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N(Cc1csc2ccccc12)[C@@H](C)C(OCC)OCC",
        "output": "133"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCN(CC)CC.C[C@@H](N)CO.Clc1ncc(Br)c(Cl)n1>>C[C@H](CO)Nc1nc(Cl)ncc1Br",
        "output": "110"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CN(C)C.Cc1cc(C)cc(Sc2[nH]c(C)nc2CO)c1.Cl.ClCCl.O=C([O-])O.[Na+]>>CC(=O)OCc1nc(C)[nH]c1Sc1cc(C)cc(C)c1",
        "output": "126"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)CC(=O)c1cccc(-n2nncc2COC2CCCCO2)c1.CCCN(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1C>>CCCN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-n3nncc3COC3CCCCO3)c2)cc1C",
        "output": "929"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.[N-]=[N+]=NCC1CCC(Oc2ccc(F)cc2)CC1.[Pd]>>NCC1CCC(Oc2ccc(F)cc2)CC1",
        "output": "89"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.CS(=O)(=O)c1ccc(F)c(C(F)(F)F)c1.O=C(O)CCc1ccc(Cl)cc1S.[H-].[Na+]>>CS(=O)(=O)c1ccc(Sc2cc(Cl)ccc2CCC(=O)O)c(C(F)(F)F)c1",
        "output": "675"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)C[C@@H]1COc2cc(O)ccc21.O.O=C1CCC(=O)N1Cl>>COC(=O)C[C@@H]1COc2cc(O)c(Cl)cc21",
        "output": "121"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCN(CCCN)CC2)c1.Cc1ccc(C(C(=O)O)c2ccc(C)cc2)cc1>>Cc1ccc(C(C(=O)NCCCN2CCC(c3cccc(NC(=O)C(C)C)c3)CC2)c2ccc(C)cc2)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CC(=O)[O-].COc1ccc(CCC#N)c(C)c1.ClC(Cl)Cl.[Na+]>>COc1cc(C)c(CCC#N)cc1Br",
        "output": "98"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CNCCN1.Clc1cccnc1Cl.O>>Clc1cccnc1N1CCNCC1",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN.Cc1nc(N2CCOc3cc(Br)ccc32)sc1C(=O)O.ClCCCl.ClCCl.O.On1nnc2ccccc21>>CNC(=O)c1sc(N2CCOc3cc(Br)ccc32)nc1C",
        "output": "534"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCn1ccc(CN)n1.O=C(O)c1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1>>CCCn1ccc(CNC(=O)c2cnc(OCC(F)(F)F)c(-c3ccc(Cl)cc3)c2)n1",
        "output": "674"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CO.COCc1nccn1Cc1ccc(-c2cc3c(CNC(=O)OC(C)(C)C)cccc3c(=O)[nH]2)cc1.Cl>>COCc1nccn1Cc1ccc(-c2cc3c(CN)cccc3c(=O)[nH]2)cc1",
        "output": "793"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.Cc1[nH]c2c(-c3cc(C(F)F)ccc3OCC3CC3)ncnc2c1C(=O)N[C@H]1CC[C@H](N)C[C@H]1F>>CC(=O)N[C@H]1CC[C@H](NC(=O)c2c(C)[nH]c3c(-c4cc(C(F)F)ccc4OCC4CC4)ncnc23)[C@H](F)C1",
        "output": "45"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COCOc1cc(-c2ccc(OCc3ccccc3)cc2)on1.[C].[Pd]>>COCOc1cc(-c2ccc(O)cc2)on1",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1cccc(Br)n1.CC1(C)OB(c2cc(F)ccc2C#N)OC1(C)C>>N#Cc1ccc(F)cc1-c1cccc(Br)n1",
        "output": "939"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.CCOC(C)=O.CCOP(=O)(CN(c1ccc2c(ccn2C(=O)CCl)c1)S(=O)(=O)c1cc(Cl)cc(Cl)c1)OCC.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCOP(=O)(CN(c1ccc2c(ccn2C(=O)CN2CCOCC2)c1)S(=O)(=O)c1cc(Cl)cc(Cl)c1)OCC",
        "output": "340"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)c1ccc(N)cc1.CCOCC.CO.ClI.O.O=C([O-])[O-].[Ca+2]>>CC(=O)c1ccc(N)c(I)c1",
        "output": "466"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.Cc1nn(C)c(Cl)c1C(=O)O.Nc1cccc(C(=O)c2ccc3c(c2)NC(=O)C3)c1.O=S(Cl)Cl>>Cc1nn(C)c(Cl)c1C(=O)Nc1cccc(C(=O)c2ccc3c(c2)NC(=O)C3)c1",
        "output": "851"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClC(Cl)Cl.ClCCl.Nc1ccccc1CCCO.O=C(O)CC1CCCCC1.On1nnc2ccccc21>>O=C(CC1CCCCC1)Nc1ccccc1CCCO",
        "output": "365"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)CCOc1ccc(NC(=O)Nc2ccc(-c3nc(N4C5COCC4CN(C(=O)OC(C)(C)C)C5)c4cnn(CC(F)(F)F)c4n3)cc2)cc1.ClCCl.O=C(O)C(F)(F)F>>CN(C)CCOc1ccc(NC(=O)Nc2ccc(-c3nc(N4C5CNCC4COC5)c4cnn(CC(F)(F)F)c4n3)cc2)cc1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNC1.Nc1cc(Cl)ccc1[N+](=O)[O-]>>Nc1cc(N2CCCC2)ccc1[N+](=O)[O-]",
        "output": "105"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)c1ccncc1.ClCCl.OCC(O)COCc1ccccc1>>CC(C)(C)[Si](C)(C)OCC(O)COCc1ccccc1",
        "output": "193"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.COC(=O)c1ccc(CO)c(C)c1.CS(=O)(=O)Cl.O>>COC(=O)c1ccc(COS(C)(=O)=O)c(C)c1",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.Nc1ccc(OCCc2ccccn2)nc1.O.O=C(Cl)c1ccccc1-c1ccc(C(F)(F)F)cc1>>O=C(Nc1ccc(OCCc2ccccn2)nc1)c1ccccc1-c1ccc(C(F)(F)F)cc1",
        "output": "501"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.O.O=C1CCN(C(=O)OCc2ccc([N+](=O)[O-])cc2)CC1.[BH4-].[Na+]>>O=C(OCc1ccc([N+](=O)[O-])cc1)N1CCC(O)CC1",
        "output": "91"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)NC(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cnccc1C(=O)O.F[P-](F)(F)(F)(F)F.Nc1ccn(Cc2ccccc2Oc2ccccc2)n1>>Cc1cnccc1C(=O)Nc1ccn(Cc2ccccc2Oc2ccccc2)n1",
        "output": "917"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)OB(c2ccc(-c3cnc(N)nc3)c(F)c2)OC1(C)C.FC(F)(F)c1cccc(Oc2ccccc2Br)n1>>Nc1ncc(-c2ccc(-c3ccccc3Oc3cccc(C(F)(F)F)n3)cc2F)cn1",
        "output": "933"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O.O=C1COCCN1c1ccccc1.O=S(=O)(O)O.O=[N+]([O-])O>>O=C1COCCN1c1ccc([N+](=O)[O-])cc1",
        "output": "21"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.CI.CN(C)C=O.O=C(OCc1ccccc1)N1CCC(O)C1.O=[Ag]>>COC1CCN(C(=O)OCc2ccccc2)C1",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CN(C)C(=O)Nc1cc(Oc2ccc([N+](=O)[O-])cc2)ccn1.CO.[C].[H][H].[Pd]>>CN(C)C(=O)Nc1cc(Oc2ccc(N)cc2)ccn1",
        "output": "335"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#CCNC(=O)OC(C)(C)C.CC(C)NC(C)C.CCOC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)cnc3Cl)nc12.CN(C)C=O.[Cu]I.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)cnc3C#CCNC(=O)OC(C)(C)C)nc12",
        "output": "818"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc2[nH]ncc2c1.C1CCOC1.CN(C)C=O.Cl.O=C([O-])O.[H-].[Li]C(C)CC.[Na+].[Na+]>>O=Cc1ccc2[nH]ncc2c1",
        "output": "638"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)C(C(=O)Cl)C1(C)C.ClCCl.Nc1ccccc1>>CC1(C)C(C(=O)Nc2ccccc2)C1(C)C",
        "output": "9"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1cnc(Nc2cnn(C)c2)nc1CCc1ccccc1CC(=O)O.Cl.Cl.O=C([O-])[O-].On1nnc2ccccc21.[NH4+].[NH4+]>>Cc1cnc(Nc2cnn(C)c2)nc1CCc1ccccc1CC(N)=O",
        "output": "313"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.NC(=O)c1nc(-c2c(F)cccc2F)oc1-c1cccc(C=O)c1.[Na+]>>NC(=O)c1nc(-c2c(F)cccc2F)oc1-c1cccc(CN2CCOCC2)c1",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(C)Oc1ccc(-c2noc(-c3ccc(F)cc3)n2)cc1Cl.CN(C)C=O.CS(C)=O.N[C@H]1CC[C@@H](C(=O)O)C1.O=C([O-])[O-].[K+].[K+]>>CC(C)Oc1ccc(-c2noc(-c3ccc(N[C@H]4CC[C@@H](C(=O)O)C4)cc3)n2)cc1Cl",
        "output": "572"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1cc2c(O)c(C#N)cnc2cc1OCCCCl.O=P(Cl)(Cl)Cl>>COc1cc2c(Cl)c(C#N)cnc2cc1OCCCCl",
        "output": "177"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)CCc1ccc(OC)cc1.COC(Cl)Cl.Cl.ClCCl.Cl[Ti](Cl)(Cl)Cl>>COC(=O)CCc1ccc(OC)c(C=O)c1",
        "output": "591"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1ccc(N=CN(C)C)cc1S(=O)(=O)NC(C)(C)C.O=C(O)C(F)(F)F>>COC(=O)c1ccc(N=CN(C)C)cc1S(N)(=O)=O",
        "output": "680"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)CN1C(=O)CC(=O)N(c2ccccc2)c2ccccc21.Cl>>O=C(O)CN1C(=O)CC(=O)N(c2ccccc2)c2ccccc21",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CC1(C)OB(c2cn[nH]c2)OC1(C)C.CN(C)CCCl.Cl.O=C([O-])[O-].[Cs+].[Cs+]>>CN(C)CCn1cc(B2OC(C)(C)C(C)(C)O2)cn1",
        "output": "604"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc(Cl)c(Oc2cc(C#N)cc(Cl)n2)c1F.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>N#Cc1cc(Cl)nc(Oc2c(Cl)ccc(CBr)c2F)c1",
        "output": "29"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc(CCc2cnc3c(N)nc4cc(CO[Si](C)(C)C(C)(C)C)ccc4c3c2)c(C)c1.[F-]>>COc1ccc(CCc2cnc3c(N)nc4cc(CO)ccc4c3c2)c(C)c1",
        "output": "708"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)Cc1ccccc1S(N)(=O)=O.NN.O>>NNC(=O)Cc1ccccc1S(N)(=O)=O",
        "output": "130"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1CCNCC1.O=Cc1ccc(-c2cc3ncnc(Nc4ccc5[nH]ccc5c4)c3s2)cc1>>CN1CCN(Cc2ccc(-c3cc4ncnc(Nc5ccc6[nH]ccc6c5)c4s3)cc2)CC1",
        "output": "567"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCCCCc1nnc(-c2ccc(O)cc2)s1.FC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)COCCCCCCl>>CCCCCCCCCCc1nnc(-c2ccc(OCCCCCOCC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)F)cc2)s1",
        "output": "74"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cc1ccc(C(=O)Cl)cc1.CC(C)O>>CC(=O)Cc1ccc(C(=O)OC(C)C)cc1",
        "output": "51"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C[N+](=O)[O-])CC1(C)OCCO1.CCO.[H][H].[Pt]>>CC(C)(CN)CC1(C)OCCO1",
        "output": "226"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COC(=O)[C@H](Cc1ccc(C=CCc2cccc(N(C)C(=O)OC(C)(C)C)n2)cc1)NC(=O)OC(C)(C)C.[Pd]>>COC(=O)[C@H](Cc1ccc(CCCc2cccc(N(C)C(=O)OC(C)(C)C)n2)cc1)NC(=O)OC(C)(C)C",
        "output": "362"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccccc1Br.Oc1ccc2[nH]ncc2c1.[K+].[K+]>>O=[N+]([O-])c1ccccc1Oc1ccc2[nH]ncc2c1",
        "output": "238"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Cl.ClCCl.O=[N+]([O-])c1ccc2c(c1)CCN2>>CC(=O)N1CCc2cc([N+](=O)[O-])ccc21",
        "output": "160"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Nc1cccc(-c2c(Cc3ccccc3)cnc3c(C(F)(F)F)cccc23)c1.O=Cc1ccc(F)cc1C(F)(F)F>>Fc1ccc(CNc2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)c(C(F)(F)F)c1",
        "output": "359"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1nc(NC(=O)c2ccncc2)sc1C(=O)O.NCCC1CC1>>Cc1nc(NC(=O)c2ccncc2)sc1C(=O)NCCC1CC1",
        "output": "534"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.ClCc1ccc2ccccc2n1.O=C1CCCc2ccc(O)cc21.[H-].[Na+]>>O=C1CCCc2ccc(OCc3ccc4ccccc4n3)cc21",
        "output": "616"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)OB(c2ccc(N)cc2)OC1(C)C.CN(C)C=O.COCCBr.O=C([O-])[O-].[K+].[K+]>>COCCNc1ccc(B2OC(C)(C)C(C)(C)O2)cc1",
        "output": "273"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)O.CCOC(C)=O.CO.COC1CNC1.COc1ccc(CN(c2nc(Nc3cc(C#N)c(CCC=O)cc3Cl)nn3c(C#N)cnc23)C2CC2)cc1.[BH3-]C#N.[Na+]>>COc1ccc(CN(c2nc(Nc3cc(C#N)c(CCCN4CC(OC)C4)cc3Cl)nn3c(C#N)cnc23)C2CC2)cc1",
        "output": "484"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C([O-])O.O=C1CCc2ccc(=O)n3c2N1C[C@H]3CO.[Na+]>>CS(=O)(=O)OC[C@@H]1CN2C(=O)CCc3ccc(=O)n1c32",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.NCC12CC3CC(CC(C3)C1)C2.Nc1cccc(C(=O)O)n1>>Nc1cccc(C(=O)NCC23CC4CC(CC(C4)C2)C3)n1",
        "output": "137"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCCCCCCCCCCCCCBr.Cc1ccc(O)c(C)c1.O=C([O-])[O-].[K+].[K+]>>CCCCCCCCCCCCCCOc1ccc(C)cc1C",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.O=C(N1CCN(c2cc(S(=O)(=O)Cl)ccc2OCC(F)(F)F)CC1)C(Cl)(Cl)Cl.O=Cc1c[nH]c2cc(F)ccc12.[H-].[Na+]>>O=Cc1cn(S(=O)(=O)c2ccc(OCC(F)(F)F)c(N3CCN(C(=O)C(Cl)(Cl)Cl)CC3)c2)c2cc(F)ccc12",
        "output": "648"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1ccc(C(=O)O)cn1.Cl.F[P-](F)(F)(F)(F)F.NCCNC(=O)c1cn(-c2ccccc2)nc1C(F)(F)F.O>>COc1ccc(C(=O)NCCNC(=O)c2cn(-c3ccccc3)nc2C(F)(F)F)cn1",
        "output": "674"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOCC.CSc1nc(Cl)c(C#N)c(Cl)n1.Nc1ccccc1>>CSc1nc(Cl)c(C#N)c(Nc2ccccc2)n1",
        "output": "161"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#CCCCCO.CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O.c1c[nH]cn1>>C#CCCCCO[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1ccc([N+](=O)[O-])cc1C#CC(C)(C)C>>CC(C)(C)C#Cc1cc([N+](=O)[O-])ccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)N1CCC(N)CC1.CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)nc1Cl.[K+].[K+]>>CCOC(=O)N1CCC(Nc2nc(Cl)ccc2[N+](=O)[O-])CC1",
        "output": "70"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)COc1ccc(Cl)c2nc(C(C)C)c(Cc3ccc(S(C)(=O)=O)cc3)c(OC(F)F)c12.[Li+].[OH-]>>CC(C)c1nc2c(Cl)ccc(OCC(=O)O)c2c(OC(F)F)c1Cc1ccc(S(C)(=O)=O)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)O.CC(C)(C)c1cc(NC(=O)C2CCCNC2)no1.CCN(CC)CC.Cl.Fc1ncc(C(F)(F)F)cc1Cl>>CC(C)(C)c1cc(NC(=O)C2CCCN(c3ncc(C(F)(F)F)cc3Cl)C2)no1",
        "output": "756"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "OCCCCCCCCBr.Oc1ccc2c(c1)c1ccccc1n2-c1ccccc1.c1ccc2c(c1)[nH]c1ccccc12>>OCCCCCCCCOc1ccc2c(c1)c1ccccc1n2-c1ccccc1",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1onc(-c2ccc(F)cn2)c1CCc1ncc(C(=O)O)s1.F[B-](F)(F)F.NC1CCOCC1>>Cc1onc(-c2ccc(F)cn2)c1CCc1ncc(C(=O)NC2CCOCC2)s1",
        "output": "534"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cl.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1.O=C(O)C1CCOCC1>>O=C(N[C@@H]1CC[C@@H](CCN2CCN(c3cccc4c3OCO4)CC2)CC1)C1CCOCC1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.CCCBr.O=C([O-])[O-].Oc1ccc2c(Cl)nccc2c1.[K+].[K+]>>CCCOc1ccc2c(Cl)nccc2c1",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.FC(F)(F)c1nc(Cl)cc(OC2CCC3(CC2)OCCO3)n1.OCCO.[H-].[Na+]>>OCCOc1cc(OC2CCC3(CC2)OCCO3)nc(C(F)(F)F)n1",
        "output": "653"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.CCN(CC)CC.C[C@@H](N)C1CCC1.Cl.Fc1cc(Cn2cnc3nc(Cl)nc(Cl)c32)ccc1C(F)(F)F>>C[C@@H](Nc1nc(Cl)nc2ncn(Cc3ccc(C(F)(F)F)c(F)c3)c12)C1CCC1",
        "output": "145"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(N)(C#N)CCC(F)(F)F.O.O=C(Cl)OCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>CC(C#N)(CCC(F)(F)F)NC(=O)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cc1nc2cccc3n(CCCN4C(=O)c5ccccc5C4=O)c(=O)c1n23.NN.O>>Cc1nc2cccc3n(CCCN)c(=O)c1n23",
        "output": "242"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCC.CCO.CCOC(C)=O.O.O=[N+]([O-])c1ccc(Oc2cc(Nc3ccccc3)ncn2)cc1.[Cl-].[Fe].[NH4+]>>Nc1ccc(Oc2cc(Nc3ccccc3)ncn2)cc1",
        "output": "335"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCCCCCBr.CN(C)C=O.O.[H-].[Na+].c1ccc2c(c1)CCCc1c-2[nH]c2ccccc12>>BrCCCCCn1c2c(c3ccccc31)CCCc1ccccc1-2",
        "output": "470"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.COCCOC(=O)Nc1cccc(CO)c1.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl>>COCCOC(=O)Nc1cccc(C=O)c1",
        "output": "179"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrBr.Cl.O=C([O-])[O-].O=C1CCCc2ccccc21.[Al+3].[Cl-].[Cl-].[Cl-].[Na+].[Na+]>>O=C1CCCc2c(Br)cccc21",
        "output": "98"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)c1ccc(C(=O)Nc2ccccc2N)cc1.COc1cccc(C(=O)O)c1>>COc1cccc(C(=O)Nc2ccccc2NC(=O)c2ccc(C(C)(C)C)cc2)c1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)C1CCCC(C2CN(Cc3ccc4cc(O[C@H]5CC[C@@H](C(C)C)CC5)ccc4c3)C2)C1.Cl.O.[Na+].[OH-]>>CC(C)[C@@H]1CC[C@H](Oc2ccc3cc(CN4CC(C5CCCC(C(=O)O)C5)C4)ccc3c2)CC1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)I.CCOC(C)=O.CCOc1cc(Br)ccc1CC#N.CS(C)=O.Cc1cc(Br)ccc1O.O=C([O-])[O-].Oc1ccccc1.[K+].[K+]>>Cc1cc(Br)ccc1OC(C)C",
        "output": "318"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.Cc1[nH]c2c(-c3cc(C(F)(F)F)ccc3OCC3CC3)ncnc2c1C(=O)N[C@@H]1CC[C@@H](N)CC1.Cl>>CC(=O)N[C@@H]1CC[C@@H](NC(=O)c2c(C)[nH]c3c(-c4cc(C(F)(F)F)ccc4OCC4CC4)ncnc23)CC1",
        "output": "45"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CNC.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CN(C)S(=O)(=O)c1ccccc1[N+](=O)[O-]",
        "output": "99"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NC1(c2ccc(-c3oc4ccnc(-c5cn[nH]c5)c4c3-c3ccccc3)cc2)CCC1.COc1nc(N(C)C)nc2oc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)c12>>NC1(c2ccc(-c3oc4ccnc(-c5cn[nH]c5)c4c3-c3ccccc3)cc2)CCC1",
        "output": "793"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.O=C(NC1CCSCC1)c1nn(-c2ccc(F)cc2F)c2c1C[C@H]1C[C@@H]21.O=C(OO)c1cccc(Cl)c1>>O=C(NC1CCS(=O)CC1)c1nn(-c2ccc(F)cc2F)c2c1C[C@H]1C[C@@H]21",
        "output": "13"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CS(C)=O.C[C@H](c1ccccc1)N(CC(O)COc1ccccc1[N+](=O)[O-])C(=O)OCc1ccccc1.ClCCl.O=C(Cl)C(=O)Cl>>C[C@H](c1ccccc1)N(CC(=O)COc1ccccc1[N+](=O)[O-])C(=O)OCc1ccccc1",
        "output": "87"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1ccc2c(O)c(-c3ccccc3)c(C)cc2c1.O=Cc1ccc(F)cc1.[H-].[Na+]>>COc1ccc2c(Oc3ccc(C=O)cc3)c(-c3ccccc3)c(C)cc2c1",
        "output": "564"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.Cl.ClCCCl.ClCCl.O=Cc1cc2nc(Cl)nc(N3CCOCC3)c2s1.[Na+].c1cnn(CC2CCNCC2)c1>>Clc1nc(N2CCOCC2)c2sc(CN3CCC(Cn4cccn4)CC3)cc2n1",
        "output": "792"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1.O=C(O)c1ccc(Cl)cc1Cl>>O=C(N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3CCO4)CC2)CC1)c1ccc(Cl)cc1Cl",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)CN.O=S(=O)(Nc1cc(-c2nc(C3CCOCC3)sc2-c2ccnc(Cl)n2)ccc1F)c1cc(F)ccc1F>>CC(C)CNc1nccc(-c2sc(C3CCOCC3)nc2-c2ccc(F)c(NS(=O)(=O)c3cc(F)ccc3F)c2)n1",
        "output": "544"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@@H]1CN(c2ccn(C)n2)CCN1.Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)O)n1.F[P-](F)(F)(F)(F)F>>Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCN(c3ccn(C)n3)C[C@H]2C)n1",
        "output": "811"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Clc1ccc(CBr)cc1.N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)O)(CC1)CC2>>N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)OCc3ccc(Cl)cc3)(CC1)CC2",
        "output": "403"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1C2CC2C[C@H]1CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C.CCCC[N+](CCCC)(CCCC)CCCC.[Cl-].[F-].[NH4+]>>CC(C)(C)OC(=O)N1C2CC2C[C@H]1CO",
        "output": "781"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)c1nc(-c2ccc(Cl)c(C(=O)O)c2)ccc1Cl.NCC1(O)CCCCCC1>>COC(=O)c1nc(-c2ccc(Cl)c(C(=O)NCC3(O)CCCCCC3)c2)ccc1Cl",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC12CCC(C1)C(C)(C)C2=O.CCO.NN.O>>CC12CCC(C1)C(C)(C)C2=NN",
        "output": "285"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "FC(F)(F)CCCBr.O=C1C(=O)c2ccccc2C2=C1SCC1(CCNCC1)O2>>O=C1C(=O)c2ccccc2C2=C1SCC1(CCN(CCCC(F)(F)F)CC1)O2",
        "output": "73"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CNOC.Cl.O=C(O)CC(c1ccc(Br)cc1)c1ccccc1C(F)(F)F>>CON(C)C(=O)CC(c1ccc(Br)cc1)c1ccccc1C(F)(F)F",
        "output": "54"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C1CCC(=O)N1Br.O=S(=O)(O)O.O=[N+]([O-])c1cccc([N+](=O)[O-])c1>>O=[N+]([O-])c1cc(Br)cc([N+](=O)[O-])c1",
        "output": "4"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)C(C)(C)Oc1ccc(C(=O)CSc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1.Cl.[Na+].[OH-]>>CC(C)(Oc1ccc(C(=O)CSc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1)C(=O)O",
        "output": "192"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Cl.NCc1ccc(OS(=O)(=O)C(F)(F)F)c(OC(F)(F)F)c1>>CC(C)(C)OC(=O)NCc1ccc(OS(=O)(=O)C(F)(F)F)c(OC(F)(F)F)c1",
        "output": "686"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.CSc1sc(-c2cc(Nc3cccc(OCCCO)c3)ccc2C)c(-c2cccnc2)c1C#N.ClCCl.O>>CSc1sc(-c2cc(Nc3cccc(OCCCOS(C)(=O)=O)c3)ccc2C)c(-c2cccnc2)c1C#N",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cn1nnc(-c2ccc(F)cc2)c1/C=C/c1ccc(C(=O)O)cn1.NC1CCOCC1>>Cn1nnc(-c2ccc(F)cc2)c1/C=C/c1ccc(C(=O)NC2CCOCC2)cn1",
        "output": "674"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1ccc2cc(O)ccc2c1.COS(=O)(=O)OC.O.[Na+].[OH-]>>COc1ccc2cc(C(C)C)ccc2c1",
        "output": "317"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.Cc1nc2cccc(CN)c2c(=O)n1C1CCC(=O)NC1=O.Cl.O=C(O)Cc1ccc(C(F)(F)F)cc1.O=C(n1ccnc1)n1ccnc1>>Cc1nc2cccc(CNC(=O)Cc3ccc(C(F)(F)F)cc3)c2c(=O)n1C1CCC(=O)NC1=O",
        "output": "599"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)c1cccc2c(S(=O)(=O)N3CCNCC3)cccc12.O=C(Cl)Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1>>CN(C)c1cccc2c(S(=O)(=O)N3CCN(C(=O)Oc4ccc(Oc5ccc(C(F)(F)F)cn5)cc4)CC3)cccc12",
        "output": "219"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)C(=NOCc1ccccc1)c1csc(N)n1.CO.Cl.[Na+].[OH-]>>Nc1nc(C(=NOCc2ccccc2)C(=O)O)cs1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)C(=O)Nc1ccc([N+](=O)[O-])cn1.CO.[Pd]>>CC(C)(C)C(=O)Nc1ccc(N)cn1",
        "output": "269"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#C[Si](C)(C)C.Fc1ccccn1.Ic1ccc(-c2ccccn2)cc1.Ic1ccc(I)cc1>>C[Si](C)(C)C#Cc1ccc(-c2ccccn2)cc1",
        "output": "826"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(C)=O.COC(=O)C(C)(C)COc1ccc(-c2ccc(-c3nc(C(F)(F)F)cn3COCC[Si](C)(C)C)cc2)cn1.Cl.O.[Cl-].[Na+].[Na+].[OH-]>>CC(C)(COc1ccc(-c2ccc(-c3nc(C(F)(F)F)cn3COCC[Si](C)(C)C)cc2)cn1)C(=O)O",
        "output": "361"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.Cc1ccc(Oc2ccc(Nc3ncnc4ccc(NC5=NC6(CCNCC6)CO5)cc34)cc2C)cn1.ClCCl.c1ccncc1>>CC(=O)N1CCC2(CC1)COC(Nc1ccc3ncnc(Nc4ccc(Oc5ccc(C)nc5)c(C)c4)c3c1)=N2",
        "output": "369"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1c(N)ccc2c1N(C)C(=O)C2(C)C.O=C(O)c1ccnc(Cl)c1>>Cc1c(NC(=O)c2ccnc(Cl)c2)ccc2c1N(C)C(=O)C2(C)C",
        "output": "50"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.CN(C)CCCCl.Cl.O=C([O-])O.O=[N+]([O-])c1ccc(N2CCNCC2)cc1.[Na+]>>CN(C)CCCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)CCCCCCN1C(=O)CC[C@@H]1C=O.COC(=O)c1ccc(/C=C\\CN2C(=O)CC[C@@H]2CO)s1>>COC(=O)c1ccc(/C=C\\CN2C(=O)CC[C@@H]2C=O)s1",
        "output": "610"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(=O)[C@@H]1COCC[C@@H]1N.CO.ClCCl>>CCOC(=O)[C@@H]1COCC[C@@H]1NC(=O)OC(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)c1ccc([C@H](C)NC(=O)[C@H](OCCOc2ccccc2)C(C)C)cc1.[Na+].[OH-]>>CC(C)[C@@H](OCCOc1ccccc1)C(=O)N[C@@H](C)c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)c1ccc(OCC2CC(=O)N(c3ccc(NC(C)=O)cc3)C2)cc1.O=S(=O)(O)O>>COC(=O)c1ccc(OCC2CC(=O)N(c3ccc(N)cc3)C2)cc1",
        "output": "66"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#Cc1ccc(OCC)cc1.CC#N.CC(Cc1ccc(I)cc1)NC(=O)OC(C)(C)C.ClCCl.[Cu]I>>CCOc1ccc(C#Cc2ccc(CC(C)NC(=O)OC(C)(C)C)cc2)cc1",
        "output": "664"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(CO)(c2ccc(F)cc2F)CC1.CC(C)(C)[O-].CO.FC(F)(F)c1cc(Br)cc(CBr)c1.O=C([O-])O.[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCC(COCc2cc(Br)cc(C(F)(F)F)c2)(c2ccc(F)cc2F)CC1",
        "output": "464"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3NC(=O)OC(C)(C)C)nc3c2C(=O)NC3)c1.Cl>>Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nc3c2C(=O)NC3)c1",
        "output": "538"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.COc1cc(N2CCC(N3CCCCC3)CC2)ccc1N.COc1ccc(-c2nc3ccccn3c2-c2ccnc(Cl)n2)cc1C(=O)Nc1c(F)cccc1F.Cc1ccc(S(=O)(=O)O)cc1.O=C([O-])O.[Na+]>>COc1cc(N2CCC(N3CCCCC3)CC2)ccc1Nc1nccc(-c2c(-c3ccc(OC)c(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)O)C(=O)C2.CCOC(=O)C1CCC(=O)CC1.Cc1ccccc1.O.OCCO>>CCOC(=O)C1CCC2(CC1)OCCO2",
        "output": "265"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CO.COC(=O)C(Oc1cc2c(cn1)-c1nc(-c3ncnn3C(C)C)cn1CCO2)C(C)C.F[P-](F)(F)(F)(F)F.O.O.[Cl-].[Li+].[NH4+].[OH-]>>CC(C)C(Oc1cc2c(cn1)-c1nc(-c3ncnn3C(C)C)cn1CCO2)C(N)=O",
        "output": "432"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)OCc2c(CCOS(C)(=O)=O)cccc2O1.CCOC(=O)C1CCNCC1.CN(C)C=O>>CCOC(=O)C1CCN(CCc2cccc3c2COC(C)(C)O3)CC1",
        "output": "496"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CN(C)[C@H]1CCCC[C@@H]1N.O=C([O-])[O-].O=C1O[C@]2(CCN(C(=O)C3(c4ccc(Br)cc4)CC3)C2)c2ccccc21.O=c1cccc[nH]1.[Cu]I.[K+].[K+]>>O=C1O[C@]2(CCN(C(=O)C3(c4ccc(-n5ccccc5=O)cc4)CC3)C2)c2ccccc21",
        "output": "349"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Nc1c(Br)cccc1C(F)(F)F.O.O=S(=O)(O)O>>Nc1c(Br)cccc1C(F)(F)F",
        "output": "66"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COc1ccccc1C(C)O.ClCCl.Clc1cncc(Cl)n1.O=C([O-])[O-].[K+].[K+]>>COc1ccccc1C(C)Oc1cncc(Cl)n1",
        "output": "209"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)[C@H](C)N)c1.NC(=O)NCC(=O)O>>COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)[C@H](C)NC(=O)CNC(N)=O)c1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.Cc1cc(O)cc(Br)c1.c1c[nH]cn1>>Cc1cc(Br)cc(O[Si](C)(C)C(C)(C)C)c1",
        "output": "746"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccc2ccncc2c1.Fc1ccc2[nH]c3c(c2c1)CN1CCC3CC1>>Fc1ccc2c(c1)c1c(n2-c2ccc3ccncc3c2)C2CCN(CC2)C1",
        "output": "349"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.II.OCCCOCc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccccc1.c1ccncc1>>ICCCOCc1ccccc1",
        "output": "670"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.O.[N-]=[N+]=N[C@H]1C[C@H](C(=O)Nc2ccc(N3CCOCC3=O)cc2)N(C(=O)Nc2ccc(Cl)cc2)C1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N[C@H]1C[C@H](C(=O)Nc2ccc(N3CCOCC3=O)cc2)N(C(=O)Nc2ccc(Cl)cc2)C1",
        "output": "89"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)c1cc(Cl)nc(Cl)c1.O=C(O)C(F)(F)F.OO>>COC(=O)c1cc(Cl)[n+]([O-])c(Cl)c1",
        "output": "396"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.Cc1c(-c2ccc(C(=O)N3CCC[C@@H](N)C3)s2)noc1C(F)(F)F.Cl>>CC(=O)N[C@@H]1CCCN(C(=O)c2ccc(-c3noc(C(F)(F)F)c3C)s2)C1",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COC(=O)C1(NC(=O)c2ccc(-c3ccc(F)c(F)c3)cc2[N+](=O)[O-])CCCCCCC1.[Pd]>>COC(=O)C1(NC(=O)c2ccc(-c3ccc(F)c(F)c3)cc2N)CCCCCCC1",
        "output": "486"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.COC(=O)c1cccc(OCCC2OCCO2)c1.O.[Na+].[OH-]>>COC(=O)c1cccc(OCCC=O)c1",
        "output": "740"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1[nH]c(C=O)c(C)c1CCC(=O)O.O.O=C1Cc2ccccc2N1.[Na+].[OH-]>>Cc1[nH]c(C=C2C(=O)Nc3ccccc32)c(C)c1CCC(=O)O",
        "output": "440"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCN(c2cc(=O)n3nc(-c4cccc(N)c4)sc3n2)CC1.CCCC[Sn](Cl)(Cl)CCCC.O=Cc1ccncc1.[SiH3]c1ccccc1>>CC(C)(C)OC(=O)N1CCN(c2cc(=O)n3nc(-c4cccc(NCc5ccncc5)c4)sc3n2)CC1",
        "output": "359"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCOC(C)=O.CS(=O)(=O)c1cccc(-c2ccc(-c3cc(C(F)(F)F)nn3-c3ccccc3Br)s2)c1.O.O=C([O-])[O-].OB(O)c1cccnc1.[K+].[K+]>>CS(=O)(=O)c1cccc(-c2ccc(-c3cc(C(F)(F)F)nn3-c3ccccc3-c3cccnc3)s2)c1",
        "output": "899"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1cc(O)c(F)cc1F.[C].[H][H].[Pd]>>Nc1cc(O)c(F)cc1F",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN1CCOCC1.COC(=O)[C@@H](N)CO.Cl.Cl.ClC(Cl)Cl.ClCCl.O=C(O)Cc1cc(F)cc(F)c1>>COC(=O)[C@H](CO)NC(=O)Cc1cc(F)cc(F)c1",
        "output": "129"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrBr.CC(=O)O.CC(=O)c1ccc2sc(=O)[nH]c2c1.ClCCl>>O=C(CBr)c1ccc2sc(=O)[nH]c2c1",
        "output": "173"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)NCc1ccccc1.O=C(O)Cc1ccc(S(=O)(=O)Cl)cc1>>CC(C)N(Cc1ccccc1)S(=O)(=O)c1ccc(CC(=O)O)cc1",
        "output": "900"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Cc1cc(O)ccc1OCCNc1ncnc2scnc12.Cl.Fc1cc(C(F)(F)F)ccn1.O.[H-].[Na+]>>Cc1cc(Oc2cc(C(F)(F)F)ccn2)ccc1OCCNc1ncnc2scnc12",
        "output": "727"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.C[O-].ClCCl.O=[N+]([O-])c1ccc(Br)cc1F.[Na+]>>COc1cc(Br)ccc1[N+](=O)[O-]",
        "output": "485"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccc(O)cc1F.ClCCCl.O.O=[N+]([O-])O.[Br-]>>Cc1cc([N+](=O)[O-])c(O)cc1F",
        "output": "21"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Nc1cccc(Nc2ccc([N+](=O)[O-])cn2)n1.O=C=O.[Pd]>>Nc1ccc(Nc2cccc(N)n2)nc1",
        "output": "269"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCCC[Sn](CCCC)(CCCC)c1ccco1.Cl[Pd]Cl.Clc1cc2c(Nc3ccc4c(cnn4Cc4ccccc4)c3)ncnc2cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>c1ccc(Cn2ncc3cc(Nc4ncnc5cnccc45)ccc32)cc1",
        "output": "40"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O=C1CCCC(=O)N1c1ccc([N+](=O)[O-])cc1.[H][H].[H][H].[Ni]>>Nc1ccc(N2C(=O)CCCC2=O)cc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.Cl.F[P-](F)(F)(F)(F)F.Nc1ncnc2cc(CN3C(=O)CN(Cc4cc5cc(Cl)ccc5[nH]4)CC3C(=O)O)ccc12>>CNC(=O)C1CN(Cc2cc3cc(Cl)ccc3[nH]2)CC(=O)N1Cc1ccc2c(N)ncnc2c1",
        "output": "216"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.Cc1[nH]c2ccc(O)cc2c1C1CCN(C)CC1.O=S(=O)(Cl)c1ccccc1.[Na+].[OH-]>>Cc1[nH]c2ccc(OS(=O)(=O)c3ccccc3)cc2c1C1CCN(C)CC1",
        "output": "380"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#Cc1ccccc1-c1c(C=CCCC)c(C(C)C)nc(C(C)C)c1C(=O)OCC.CCCCCC.CCOC(C)=O>>C#Cc1ccccc1-c1c(C=CCCC)c(C(C)C)nc(C(C)C)c1CO",
        "output": "383"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(COc2ccc(-c3ccc(OC)cn3)cc2)c(C)o1.[Li+].[OH-]>>COc1ccc(-c2ccc(OCc3cc(C(=O)O)oc3C)cc2)nc1",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCN(CCCC)C(=O)c1nn(-c2ccc(C(=O)O)cc2C(=O)N2CCc3ccccc3C2)c(C)c1Br.CCCCN(Cc1ccc(Cl)c(Cl)c1)C(=O)c1nn(-c2ccc(C(=O)OCc3ccccc3)cc2C(=O)N2CCc3ccccc3C2)c(C)c1Cl>>CCCCN(Cc1ccc(Cl)c(Cl)c1)C(=O)c1nn(-c2ccc(C(=O)O)cc2C(=O)N2CCc3ccccc3C2)c(C)c1Cl",
        "output": "290"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.CCCCCC.CCOC(C)=O.CN(C)C=O.COc1ccc(C[C@H](NC(=O)OC(C)(C)C)[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)O)cc1.O.O=C([O-])[O-].[K+].[K+].c1c[nH]cn1>>COc1ccc(C[C@H](NC(=O)OC(C)(C)C)[C@H](C[C@@H](Cc2ccccc2)C(=O)O)O[Si](C)(C)C(C)(C)C)cc1",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1cn2c(c1O)C(=O)N(C)CC2.CI.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1cn2c(c1OC)C(=O)N(C)CC2",
        "output": "661"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COCC(=O)Nc1cc([N+](=O)[O-])cc(C(F)(F)F)c1.[Pd]>>COCC(=O)Nc1cc(N)cc(C(F)(F)F)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)c1cc(Cl)c(C(=O)c2c[nH]c3c(NC(=O)C4CC4)nccc23)c(Cl)c1.O.[BH4-].[Na+]>>O=C(c1c(Cl)cc(CO)cc1Cl)c1c[nH]c2c(NC(=O)C3CC3)nccc12",
        "output": "444"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.O=C1CCC(O)CC1.OCCO.c1ccccc1>>OC1CCC2(CC1)OCCO2",
        "output": "265"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCc1cc2cc(Cl)cc(Cn3nc(C(=O)OCC)cc3C)c2o1.CCO.[Na+].[OH-]>>CCCc1cc2cc(Cl)cc(Cn3nc(C(=O)O)cc3C)c2o1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.OCc1cc2ccccc2cn1>>O=Cc1cc2ccccc2cn1",
        "output": "263"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCC(CN)(c2ccccc2)CC1.Cc1ccc(Cl)c(C(=O)O)c1>>Cc1ccc(Cl)c(C(=O)NCC2(c3ccccc3)CCN(C)CC2)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.COc1ccc(C[C@H](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)O)c(OC)c1OC.c1c[nH]cn1>>COc1ccc(C[C@H](C[C@H](O[Si](C)(C)C(C)(C)C)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)O)c(OC)c1OC",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2ccc(Br)cc2C2CC(=O)NC(c3cccc(Cl)c3)C23C(=O)Nc2cc(Cl)ccc23)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C1CC(c2cc(Br)ccc2OC2CCNCC2)C2(C(=O)Nc3cc(Cl)ccc32)C(c2cccc(Cl)c2)N1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)Oc1ccc(C=O)cc1.O=C(O)CC(=O)O.c1ccncc1>>CC(C)Oc1ccc(C=CC(=O)O)cc1",
        "output": "12"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.O=C(CCl)c1cc2n(n1)CCN(C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2.OC[C@@H]1CCCN1>>O=C(CN1CCC[C@H]1CO)c1cc2n(n1)CCN(C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2",
        "output": "414"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CC(=O)NCCCCCC(=O)N[C@@H](Cc1ccccc1)C(=O)OCC.CO>>C=CC(=O)NCCCCCC(=O)N[C@@H](Cc1ccccc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.CCOC(C)=O.CN1CCOCC1.Cl.O=C(O)c1ccc([N+](=O)[O-])c(F)c1.On1nnc2ccccc21.[NH4+].[OH-]>>NC(=O)c1ccc([N+](=O)[O-])c(F)c1",
        "output": "358"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCCc1ccc(Br)cc1.CCN(CC)CC.CN(C)C=O.O=[N+]([O-])c1ccc(CCN2CCNCC2)cc1>>O=[N+]([O-])c1ccc(CCN2CCN(CCc3ccc(Br)cc3)CC2)cc1",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.C[C@@H]1[C@H](N)C[C@H]2C(C)(C)CCC[C@]2(C)[C@H]1C(=O)c1cc(O)cc(O)c1.F[B-](F)(F)F>>C[C@@H]1[C@H](NC(=O)C2CCN(C(=O)OC(C)(C)C)CC2)C[C@H]2C(C)(C)CCC[C@]2(C)[C@H]1C(=O)c1cc(O)cc(O)c1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cc1ccc(-c2ccccc2[N+](=O)[O-])cc1.[Ni]>>Cc1ccc(-c2ccccc2N)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN(C(=O)OC(C)(C)C)C1=N[C@@H]2[C@@H](O)[C@H](O)[C@@H]([C@@H](O)C(F)(F)F)O[C@@H]2S1.CN(C)C=O.C[Si](C)(C)[N-][Si](C)(C)C.Fc1ccc(CCl)cc1.[K+]>>CN(C(=O)OC(C)(C)C)C1=N[C@@H]2[C@@H](O)[C@H](O)[C@@H]([C@@H](OCc3ccc(F)cc3)C(F)(F)F)O[C@@H]2S1",
        "output": "208"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCOCC1.COc1ccc(OC)c2c1CC1=C(O2)C(=O)N([C@@H](CC(C)C)C(=O)O)C1.F[P-](F)(F)(F)(F)F.Nc1ccc(Cl)cn1.O>>COc1ccc(OC)c2c1CC1=C(O2)C(=O)N([C@@H](CC(C)C)C(=O)Nc2ccc(Cl)cn2)C1",
        "output": "368"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COc1ccc2[nH]c(C(=O)N3CC(CCl)c4c3cc([N+](=O)[O-])c3ccccc43)cc2c1.O=[Pt]=O>>COc1ccc2[nH]c(C(=O)N3CC(CCl)c4c3cc(N)c3ccccc43)cc2c1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CN=C=S.NCCCSc1cncc(NC(N)=NCC(F)(F)F)n1>>CNC(=S)NCCCSc1cncc(NC(N)=NCC(F)(F)F)n1",
        "output": "79"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNCC(C)C.Cc1ccc(-c2cc(C(=O)O)nn2-c2cccnc2)nc1>>Cc1ccc(-c2cc(C(=O)N(C)CC(C)C)nn2-c2cccnc2)nc1",
        "output": "663"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.COC(=O)CC(c1ccc(F)c(O)c1)C1CC1.COc1ccc(F)c(-c2ccc(CCl)nc2CC(C)(C)C)c1.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)CC(c1ccc(F)c(OCc2ccc(-c3cc(OC)ccc3F)c(CC(C)(C)C)n2)c1)C1CC1",
        "output": "616"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc(C(=O)C(=O)c2ccc(OC)cc2)cc1.ClCCl>>O=C(C(=O)c1ccc(O)cc1)c1ccc(O)cc1",
        "output": "20"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OC[C@@H](Cn2ccc(N)n2)O1.O=C(O)C(CC1CCCCC1)n1ncc(Oc2c(F)cccc2F)cc1=O>>CC1(C)OC[C@@H](Cn2ccc(NC(=O)C(CC3CCCCC3)n3ncc(Oc4c(F)cccc4F)cc3=O)n2)O1",
        "output": "795"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CCOC(=O)c1cc2c(nc1C)CCCCC2=O.CO.[BH4-].[Cl-].[NH4+].[Na+]>>CCOC(=O)c1cc2c(nc1C)CCCCC2O",
        "output": "449"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCCCC.CN(C)C=O.COc1c(F)cccc1Cl.Cl.[Li]CCCC>>COc1c(Cl)ccc(C=O)c1F",
        "output": "239"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CI.O=C(OCc1ccccc1)N1CCC(F)(CO)C1.[H-].[Na+]>>COCC1(F)CCN(C(=O)OCc2ccccc2)C1",
        "output": "140"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#Cc1cc(Cl)ccc1OCC(=O)OC(C)(C)C.CCCS(=O)(=O)c1ccc(F)c(C#C[Si](C)(C)C)c1.CS(=O)(=O)c1cc(Br)ccc1-c1cccc(Cl)c1>>CC(C)(C)OC(=O)COc1ccc(Cl)cc1C#Cc1ccc(-c2cccc(Cl)c2)c(S(C)(=O)=O)c1",
        "output": "659"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)c1nc2ccccc2[nH]1.Cn1c(CN2CCN(C(C)(C)CO)CC2)nc2c(N3CCOCC3)nc(Cl)nc21>>CC(C)c1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCN(C(C)(C)CO)CC3)n(C)c2n1",
        "output": "916"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CN1CCOCC1.COc1cc(OC)cc(N2CCNCC2)c1.F[P-](F)(F)(F)(F)F.O=C(O)C1c2ccccc2Oc2ccccc21>>COc1cc(OC)cc(N2CCN(C(=O)C3c4ccccc4Oc4ccccc43)CC2)c1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCCC1CCCCC1.CCO.NC(=O)CC(C(=O)O)c1ccc(O)cc1.[Na+].[OH-]>>NC(=O)CC(C(=O)O)c1ccc(OCCC2CCCCC2)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1nc2c(s1)CCOc1ccc(F)cc1-2.[Li+].[OH-]>>O=C(O)c1nc2c(s1)CCOc1ccc(F)cc1-2",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)CCS.N#Cc1cccc(Cl)n1.[H-].[Na+]>>CC(C)CCSc1cccc(C#N)n1",
        "output": "333"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.O=CC1CCN(c2ccc(CN3CCCC3)cc2)CC1>>c1cc(N2CCC(CN3CCOCC3)CC2)ccc1CN1CCCC1",
        "output": "484"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1CNCCN1.O=C(Nc1ccc(Cl)c(NC(=O)c2ccccc2)c1)c1ccc(Cl)nc1>>CC1CN(c2ccc(C(=O)Nc3ccc(Cl)c(NC(=O)c4ccccc4)c3)cn2)CCN1",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)c1ccc(Oc2ccc3nc(C(=O)N4CCN(C(=O)OC(C)(C)C)CC4)ccc3c2)cc1.CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc3cc(Oc4ccc(C(F)(F)F)cn4)ccc3n2)CC1>>CC(=O)c1ccc(Oc2ccc3nc(C(=O)N4CCNCC4)ccc3c2)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCCCOc1ccc(-c2ncc(-c3ccc(Br)cc3)s2)cc1.Cl.O.O=C=O.[Li]CCCC>>CCCCCOc1ccc(-c2ncc(-c3ccc(C(=O)O)cc3)s2)cc1",
        "output": "654"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCN(CC)CC.CN(C)C=O.NCCCCCC(=O)O.O=C(O)CCC(=O)Nc1cccc2ccccc12>>O=C(O)CCCCCNC(=O)CCC(=O)Nc1cccc2ccccc12",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.CSc1ncc(Br)c(C(=O)O)n1.O=S(=O)(O)O>>COC(=O)c1nc(SC)ncc1Br",
        "output": "331"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#Cc1cnn2c(C(F)(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12.CN(C)CCNS(=O)(=O)c1cccc(Br)c1>>CN(C)CCNS(=O)(=O)c1cccc(C#Cc2cnn3c(C(F)(F)F)cc(-c4ccc(C(F)(F)F)cc4)nc23)c1",
        "output": "659"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)N(CCCc1ccccc1)[C@@H]1CC[C@@H](c2ccc(O)cc2)CC1.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCN(CCCc1ccccc1)[C@@H]1CC[C@@H](c2ccc(O)cc2)CC1",
        "output": "112"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNCC1.CCO.Cc1[nH]c(C=O)c(C)c1C(=O)NCCn1ccnn1.O=C1Cc2c(cccc2-c2ccc(OC(F)(F)F)cc2)N1>>Cc1[nH]c(C=C2C(=O)Nc3cccc(-c4ccc(OC(F)(F)F)cc4)c32)c(C)c1C(=O)NCCn1ccnn1",
        "output": "440"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)CCCNC1.CCOC(=O)c1cn(C)c2cnc3cc(F)c(F)cc3c2c1=O.CS(C)=O.O>>CCOC(=O)c1cn(C)c2cnc3cc(N4CCCC(C)(C)C4)c(F)cc3c2c1=O",
        "output": "676"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.COc1cccnc1C1CCN(C(=O)OC(C)(C)C)CC1.Cl>>COc1cccnc1C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CC#N.CCN(c1ccccc1C(C)C)C(C)C.Cc1cccc(-c2nc3ccc(OCCCCl)cc3n2Cc2ccccc2)c1>>Cc1cccc(-c2nc3ccc(OCCCN4CCOCC4)cc3n2Cc2ccccc2)c1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(Br)cc1.Cc1ccc(B(O)O)cc1.O.O=C([O-])[O-].[Na+].[Na+]>>COc1ccc(-c2ccc(C)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cl.Clc1cc2c(nn1)-c1ccccc1CC2.[NH4+].c1ccc(N2CCNCC2)cc1>>c1ccc(N2CCN(c3cc4c(nn3)-c3ccccc3CC4)CC2)cc1",
        "output": "406"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CCC=CC[C@@H]1CC[C@@](C)(O)C1(C)C>>CCC=CC[C@@H]1CC[C@@](C)(OC(C)=O)C1(C)C",
        "output": "126"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CCN(CC)CC.O=C(C1CCCNC1)N1CCC(c2cccnc2)C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>O=C(C1CCCN(S(=O)(=O)c2ccccc2[N+](=O)[O-])C1)N1CCC(c2cccnc2)C1",
        "output": "99"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "B.CO.CSC.ClCCl.N.N#CC[C@@H](O)c1cccc(OCC2CCN(C(=O)OCc3ccccc3)CC2)n1>>NCC[C@@H](O)c1cccc(OCC2CCN(C(=O)OCc3ccccc3)CC2)n1",
        "output": "246"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CCOC(=O)c1sc(N2CCN(CCO[Si](C)(C)C(C)(C)C)C2=O)cc1C>>CCOC(=O)c1sc(N2CCN(CCO)C2=O)cc1C",
        "output": "708"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1cn(C2CC2)c2nc3cc(F)c(F)cc3cc2c1=O.CN(C)C1CNC1.Cl.Cl>>CCOC(=O)c1cn(C2CC2)c2nc3cc(N4CC(N(C)C)C4)c(F)cc3cc2c1=O",
        "output": "676"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "NC(=NO)c1ccc(F)cc1F.O=C(O)C1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)N2CC(O)C2)C1>>O=C(N1CC(O)C1)N1CC(c2ccc(C(F)(F)F)cc2)CC(c2nc(-c3ccc(F)cc3F)no2)C1",
        "output": "926"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=O)Cl.CCN(C(C)C)C(C)C.ClCCl.c1ccc(CN2CCCC(Nc3ccccc3)C2)cc1>>CCC(=O)N(c1ccccc1)C1CCCN(Cc2ccccc2)C1",
        "output": "160"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)(C)[O-].CC1(C)OB(c2ccc(NC(=O)NC3CC3)cc2)OC1(C)C.CC12COCCN1c1nc(Cl)ncc1N(CC1CCOC1)C2=O.CO.[Na+]>>CC12COCCN1c1nc(-c3ccc(NC(=O)NC4CC4)cc3)ncc1N(CC1CCOC1)C2=O",
        "output": "974"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCCCCCC(=O)Cl.CCOC(=O)Cc1csc(N)n1>>CCCCCCCCCCCC(=O)Nc1nc(CC(=O)OCC)cs1",
        "output": "553"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O=C(O)C1C2CC3CC(C2)CC1C3.O=CO.c1ccc2c(c1)CCN2>>O=C(C1C2CC3CC(C2)CC1C3)N1CCc2ccccc21",
        "output": "315"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)c1cc(Cl)c(NC(=O)CCl)c(Cl)c1.CC1CN(C(=O)OC(C)(C)C)CCN1.CCN(CC)CC.CN(C)C=O>>CC(=O)c1cc(Cl)c(NC(=O)CN2CCN(C(=O)OC(C)(C)C)CC2C)c(Cl)c1",
        "output": "340"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@@H](N)c1ccccc1.C[C@@H]1CC[C@H](C(=O)O)CN1c1cc(-c2ccc(C#N)c(F)c2)nc(N)n1.F[P-](F)(F)(F)(F)F>>C[C@@H](NC(=O)[C@H]1CC[C@@H](C)N(c2cc(-c3ccc(C#N)c(F)c3)nc(N)n2)C1)c1ccccc1",
        "output": "599"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN(C)c1ccc(-c2ccnc(-n3cc(C(=O)O)c(N)n3)n2)cc1.CN1CCN(CCc2ccc(N)cc2)CC1.F[P-](F)(F)(F)(F)F>>CN1CCN(CCc2ccc(NC(=O)c3cn(-c4nccc(-c5ccc(N(C)C)cc5)n4)nc3N)cc2)CC1",
        "output": "851"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.NC(=O)c1ccc(N)nc1.O=C(CBr)c1ccc(F)cc1.[Na+].[OH-]>>NC(=O)c1ccc2nc(-c3ccc(F)cc3)cn2c1",
        "output": "508"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COc1cc(C(=O)N(C)c2ccc(C)cc2OCc2ccccc2)ccc1NC(=O)c1cccc2[nH]c(CN)nc12.[H][H].[OH-].[OH-].[Pd+2]>>COc1cc(C(=O)N(C)c2ccc(C)cc2O)ccc1NC(=O)c1cccc2[nH]c(CN)nc12",
        "output": "23"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CN(C)C=O.CNCCNC.Cc1nccc2c1c(=O)n(C)c1cc(OC[C@H](CC(C)C)NC(=O)OC(C)(C)C)c(Br)cc21.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+].c1cn[nH]c1>>Cc1nccc2c1c(=O)n(C)c1cc(OC[C@H](CC(C)C)NC(=O)OC(C)(C)C)c(-n3cccn3)cc21",
        "output": "919"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC1CN(C(=O)OCc2ccccc2)CCC1NC(=O)OC(C)(C)C.[OH-].[OH-].[Pd+2]>>COC1CNCCC1NC(=O)OC(C)(C)C",
        "output": "428"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#Cc1ccc(CCC(=O)OC)cc1.Oc1ccccc1I>>COC(=O)CCc1ccc(C#Cc2ccccc2O)cc1",
        "output": "664"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(S(=O)c2ccccc2)cc1[N+](=O)[O-].Cc1ccc(S(=O)c2ccc(C)cc2-c2ccc(N)c([N+](=O)[O-])c2)c(-c2ccc(N)c([N+](=O)[O-])c2)c1>>COc1ccc(S(=O)c2ccccc2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(CCN(C)C(=O)OCc1ccccc1)OCC.O=C(O)C(F)(F)F>>CN(CCC=O)C(=O)OCc1ccccc1",
        "output": "409"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(C(CO)N2CCC(c3c[nH]c4ccccc34)CC2)CC1.CCN(CC)CC.CNC.CS(=O)(=O)Cl.Cl>>CN(C)CC(C1CCN(C(=O)OC(C)(C)C)CC1)N1CCC(c2c[nH]c3ccccc23)CC1",
        "output": "371"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCO.COC(=O)C1(c2ccc(N)cc2)CCC1.OC[C@@H](Nc1cc(-c2ccccc2)nc(Cl)n1)c1ccccc1>>COC(=O)C1(c2ccc(Nc3nc(N[C@H](CO)c4ccccc4)cc(-c4ccccc4)n3)cc2)CCC1",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C1CCN(CCOc2ccc(C=CC(=O)N[C@@H]3CC[C@@H](C)CC3)cc2OC)CC1.CO.Cl.[K+].[OH-]>>COc1cc(C=CC(=O)N[C@@H]2CC[C@@H](C)CC2)ccc1OCCN1CCC(C(=O)O)CC1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.Clc1cnc(Cl)c(Cl)c1.OCCN1CCOCC1.[H-].[H][H].[Na+]>>Clc1cnc(OCCN2CCOCC2)c(Cl)c1",
        "output": "433"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(O)c2ccc(Cl)cc2)CC1.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CC(C)(C)OC(=O)N1CCC(C(=O)c2ccc(Cl)cc2)CC1",
        "output": "32"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)[C@@H](C(C)C)N1Cc2ccc(-c3ccc([N+](=O)[O-])cc3)cc2C1=O.COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O>>COC(=O)[C@@H](C(C)C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)NCC(=O)c1cc(F)c(N)c(Cl)c1.Cl.Cl.[BH4-].[Na+]>>CC(C)(C)NCC(O)c1cc(F)c(N)c(Cl)c1",
        "output": "24"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.N#CCN1CCCC(O)C1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCCN1CCCC(O)C1",
        "output": "246"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(Br)cc2[N+](=O)[O-])CC1.CO.ClCCl.[BH4-].[Na+]>>CC(C)(C)OC(=O)N1CCN(c2ccc(Br)cc2N)CC1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCC[C@@H](C)OC(=O)c1ccc(-c2ccc(OC(C)=O)cc2)cc1.CN.CO.Cc1ccccc1>>CCCCCCC[C@@H](C)OC(=O)c1ccc(-c2ccc(O)cc2)cc1",
        "output": "22"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.O=Cc1ccc(O)cc1.OCc1cccc(OCc2ccccc2)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=Cc1ccc(OCc2cccc(OCc3ccccc3)c2)cc1",
        "output": "347"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNCC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.O=Cc1cc2ccc(Oc3nc4ncccc4s3)cc2[nH]1.[Na+]>>c1cnc2nc(Oc3ccc4cc(CN5CCCCC5)[nH]c4c3)sc2c1",
        "output": "829"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1=COCCC1.C1CCOC1.Cc1cc(Oc2c[nH]nc2C2CC2)cc(C)c1C#N.Cc1ccc(S(=O)(=O)O)cc1>>Cc1cc(Oc2cn(C3CCCCO3)nc2C2CC2)cc(C)c1C#N",
        "output": "878"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCNCC.O=C(Cl)c1cc(C(F)(F)F)ccc1C(F)(F)F>>CCN(CC)C(=O)c1cc(C(F)(F)F)ccc1C(F)(F)F",
        "output": "201"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(=O)[O-].CCOC(=O)C(C)CN.Cl.ClCCl.O=C1CCCC1.[Na+].[Na+]>>CCOC(=O)C(C)CNC1CCCC1",
        "output": "236"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=Cc1c(N)nc(-c2ccc(Cl)c(OC)c2F)nc1C(=O)OC.O.[Na+].[OH-]>>C=Cc1c(N)nc(-c2ccc(Cl)c(OC)c2F)nc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(O)Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.CC1(C)CNC(=O)N1c1nc2c(s1)CCOc1cc(Br)ccc1-2>>CC(C)(O)Cn1cc(-c2ccc3c(c2)OCCc2sc(N4C(=O)NCC4(C)C)nc2-3)cn1",
        "output": "971"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C[C@@H]1CCCN(C(=O)c2cc(F)c(F)cc2-c2ncccn2)[C@@H]1CN1C(=O)c2ccccc2C1=O.Cc1ccc(-c2cnn(C)c2)c(C(=O)N2CCC[C@@H](C)[C@H]2CN)c1>>C[C@@H]1CCCN(C(=O)c2cc(F)c(F)cc2-c2ncccn2)[C@@H]1CN",
        "output": "242"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.Nc1ccc(Cl)c(Cl)c1.O=C(O)CCl>>O=C(CCl)Nc1ccc(Cl)c(Cl)c1",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.CCN=C=NCCCN(C)C.Cl.ClCCl.Clc1ccc(OC2CCNCC2)cc1Cl.O=C([O-])O.[Na+]>>CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC(Oc2ccc(Cl)c(Cl)c2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCc1cc(CCC2(C3CCCC3)CC(O)=C(Cc3nc4nc(C)cc(C)n4n3)C(=O)O2)ccc1OCCN(C)C(=O)OC(C)(C)C.CCc1cc(CCC2(C3CCCC3)CC(O)=C(Cc3nc4nc(C)cc(C)n4n3)C(=O)O2)ccc1OCCNC(=O)OC(C)(C)C>>CCc1cc(CCC2(C3CCCC3)CC(O)=C(Cc3nc4nc(C)cc(C)n4n3)C(=O)O2)ccc1OCCNC",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cl.O=[N+]([O-])c1cnc2[nH]c(CO)nc2c1.[NH4+].[OH-]>>Nc1cnc2[nH]c(CO)nc2c1",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)O.N.N#Cc1cc(F)ccc1Oc1ccc2c(cnn2CCO)c1.O>>NCc1cc(F)ccc1Oc1ccc2c(cnn2CCO)c1",
        "output": "175"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COc1ccc(C=O)cc1.O=C1CCCc2cc(OCCn3ccnc3)ccc21.[K+].[OH-]>>COc1ccc(C=C2CCc3cc(OCCn4ccnc4)ccc3C2=O)cc1",
        "output": "85"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(=O)c1ccc(Cl)cc1.CCCCCCNc1c(C)cccc1C.Cc1cccc(B(O)O)c1.[Cs+].[F-].[Pd+2]>>CC(=O)c1ccc(-c2cccc(C)c2)cc1",
        "output": "892"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccccc1.C1COCCO1.CC(=O)N1c2ccc(N3CCOCC3)cc2[C@H](N)[C@@H](C)[C@@H]1C1CC1.CC(C)(C)[O-].CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CC(=O)N1c2ccc(N3CCOCC3)cc2[C@H](Nc2ccccc2)[C@@H](C)[C@@H]1C1CC1",
        "output": "932"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl.NCc1ccc(Cl)cc1.O=C(O)c1cnc2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc2c1.On1nnc2ccccc21>>O=C(NCc1ccc(Cl)cc1)c1cnc2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc2c1",
        "output": "790"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Nc1c(C)cc(F)cc1[N+](=O)[O-].Cl.O>>Cc1cc(F)cc([N+](=O)[O-])c1N",
        "output": "66"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COc1ccc2ncc(C#N)c(CCN3CCC(C)(CN)C3)c2c1.Cl.ClCCl.O=Cc1ccc2c(n1)NC(=O)CS2>>COc1ccc2ncc(C#N)c(CCN3CCC(C)(CNCc4ccc5c(n4)NC(=O)CS5)C3)c2c1",
        "output": "775"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)C(C)=Cc1ccc(C(=O)CC(C)CCCC(C)CCCC(C)C)o1.Cl.O.[Na+].[OH-]>>CC(=Cc1ccc(C(=O)CC(C)CCCC(C)CCCC(C)C)o1)C(=O)O",
        "output": "122"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(N[C@@H]1CCCC[C@@H]1O)c1cc(Br)c(OCC(F)(F)F)nc1C(F)(F)F.OB(O)c1ccc(Cl)cc1>>O=C(N[C@@H]1CCCC[C@@H]1O)c1cc(-c2ccc(Cl)cc2)c(OCC(F)(F)F)nc1C(F)(F)F",
        "output": "833"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.COCOc1cccc(CO)c1.Oc1ccc(Cl)cc1>>COCOc1cccc(COc2ccc(Cl)cc2)c1",
        "output": "347"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.COCCn1c(-c2ccc(C(C)C)cc2)nc2cc(C(C)O)cc(OC)c21.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>COCCn1c(-c2ccc(C(C)C)cc2)nc2cc(C(C)=O)cc(OC)c21",
        "output": "32"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)N=S(C)(=O)Cc1cccc([N+](=O)[O-])c1.[Cl-].[Cl-].[Cl-].[Cl-].[Na+].[Na+].[OH-].[Ti+3]>>CCOC(=O)N=S(C)(=O)Cc1cccc(N)c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.C[O-].Nc1nc(Cl)nc2nc[nH]c12.[Na+]>>COc1nc(N)c2[nH]cnc2n1",
        "output": "213"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCC(Nc1ccc(C(=O)O)cc1)c1oc2ccc(OC)cc2c1C.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(=O)CCNC.CN(C)C=O.Cl.O.On1nnc2ccccc21.[Cl-].[NH4+]>>CCCCCCC(Nc1ccc(C(=O)N(C)CCC(=O)OCC)cc1)c1oc2ccc(OC)cc2c1C",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(=O)CC(C)=O.Cc1n[nH]c(C)c1CC(=O)OC(C)(C)C.O=C([O-])[O-].O=[N+]([O-])c1ccc(CBr)c(Cl)c1.[K+].[K+]>>Cc1nn(Cc2ccc([N+](=O)[O-])cc2Cl)c(C)c1CC(=O)OC(C)(C)C",
        "output": "635"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1cn2c3c(cc(C#CCNC(=O)OC(C)(C)C)cc3c1=O)CCC2.ClCCl>>CCOC(=O)c1cn2c3c(cc(CCCNC(=O)OC(C)(C)C)cc3c1=O)CCC2",
        "output": "717"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CN(C)C=O.O=C(Nc1nccc2cc(Br)ccc12)c1ccccc1.[Li]CCCC>>O=Cc1ccc2c(NC(=O)c3ccccc3)nccc2c1",
        "output": "638"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN.CN1CCCC1=O.Clc1cc(Nc2nccc3nn(-c4c(Cl)cccc4Cl)cc23)ncn1>>CNc1cc(Nc2nccc3nn(-c4c(Cl)cccc4Cl)cc23)ncn1",
        "output": "166"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](N)CC1.COc1cc(OCC2CC2)c(-c2ncnc3c(C(=O)O)c(C)n(COCC[Si](C)(C)C)c23)cc1F>>COc1cc(OCC2CC2)c(-c2ncnc3c(C(=O)N[C@@H]4CC[C@@H](NC(=O)OC(C)(C)C)CC4)c(C)n(COCC[Si](C)(C)C)c23)cc1F",
        "output": "737"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2COS(C)(=O)=O)C(C)C)ccc1C.[N-]=[N+]=[N-].[Na+]>>COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CN=[N+]=[N-])C(C)C)ccc1C",
        "output": "322"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1cc(I)ccc1F.OCC1(CO)CC1.[K+].[K+]>>O=[N+]([O-])c1cc(I)ccc1OCC1(CO)CC1",
        "output": "485"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)COc1ccccc1CC.ClC(Cl)Cl.O=S(=O)(O)Cl>>CCOC(=O)COc1ccc(S(=O)(=O)Cl)cc1CC",
        "output": "182"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Cn1ccc2c(C#N)cccc21.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cn1ccc2c(CN)cccc21",
        "output": "175"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=CCc1c(Cl)ncnc1-c1ccccc1.[BH4-].[Na+]>>OCCc1c(Cl)ncnc1-c1ccccc1",
        "output": "223"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.COc1ccc(N(C)c2nc(NCCO)nc3ccccc23)cc1.O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)OCc1ccccc1.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>>COc1ccc(N(C)c2nc(NCCOC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OCc3ccccc3)nc3ccccc23)cc1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)s1.O=Cc1ccc(O)cc1>>O=C(C=Cc1ccc(O)cc1)c1ccc(-c2ccc(C(F)(F)F)cc2)s1",
        "output": "295"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CN(C)C=O.ClC(Cl)Cl.ClCCCl.O=P(Cl)(Cl)Cl.[Na+].c1c[nH]c(-c2cnco2)c1>>O=Cc1ccc(-c2cnco2)[nH]1",
        "output": "641"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COc1cc(I)ccc1Br.O=C([O-])[O-].O=[N+]([O-])c1cc[nH]n1.ON=Cc1ccccc1O.[Cs+].[Cs+]>>COc1cc(-n2ccc([N+](=O)[O-])n2)ccc1Br",
        "output": "901"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCC(C(c1ccc2nc(NC(=O)c3ccc(C(=O)OC)cc3)sc2c1)n1ccnc1)N(C)C.O.[Li+].[OH-]>>CCC(C(c1ccc2nc(NC(=O)c3ccc(C(=O)O)cc3)sc2c1)n1ccnc1)N(C)C",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.CCOC(=O)CCCc1cccc(-c2noc(-c3cnc(OC(C)C)c(Cl)c3)n2)c1CC.Cl.O.[Na+].[OH-]>>CCc1c(CCCC(=O)O)cccc1-c1noc(-c2cnc(OC(C)C)c(Cl)c2)n1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "N#Cc1ncc(-c2cc(Cl)nc3c2CCC3)cn1.OCc1cccc(F)n1>>N#Cc1ncc(-c2cc(OCc3cccc(F)n3)nc3c2CCC3)cn1",
        "output": "433"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)Cl.ClCCl.O=C(Cc1ccc(Cl)c(Cl)c1)N1CCNC2CCCC(N3CCCC3)C21>>COC(=O)N1CCN(C(=O)Cc2ccc(Cl)c(Cl)c2)C2C(N3CCCC3)CCCC21",
        "output": "219"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)Cc1cc(OCc2ccc(F)cc2)ccc1C(=O)O>>COC(=O)Cc1cc(OCc2ccc(F)cc2)ccc1CO",
        "output": "72"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CSc1c(Cl)ccc2c3c(n(C)c12)CCN(C(=O)OC(C)(C)C)C3.ClCCl.O=C(O)C(F)(F)F>>CSc1c(Cl)ccc2c3c(n(C)c12)CCNC3",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.COC(=O)C1CNCCN1C(=O)OC(C)(C)C.Clc1cc2ncnc(Cl)c2cc1Br>>COC(=O)C1CN(c2ncnc3cc(Cl)c(Br)cc23)CCN1C(=O)OC(C)(C)C",
        "output": "296"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC(=O)O)C(=O)c1ccc2c(c1)c1c(n2S(=O)(=O)CC)CCC(C2CCOCC2)C1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCC(F)(F)F>>CCN(CC(=O)NCC(F)(F)F)C(=O)c1ccc2c(c1)c1c(n2S(=O)(=O)CC)CCC(C2CCOCC2)C1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(=O)N1c2ccccc2[C@H](N)[C@@H](C)[C@@H]1C1CC1.CC(C)(C)[O-].CC=O.CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.N#Cc1ccccc1Br.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CC(=O)N1c2ccccc2[C@H](Nc2ccccc2C#N)[C@@H](C)[C@@H]1C1CC1",
        "output": "932"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1cc(C2CCCN2C(=O)OC(C)(C)C)c2oc(N3CCO[C@H](C)C3)cc(=O)c2c1.Cl.ClCCl>>COC(=O)c1cc(C2CCCN2)c2oc(N3CCO[C@H](C)C3)cc(=O)c2c1",
        "output": "887"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1CCCCN1C(=O)[C@H](CCCNC(=N)N)NS(=O)(=O)c1ccc2cc(OC)ccc2c1.CO.[Na+].[OH-]>>COc1ccc2cc(S(=O)(=O)N[C@@H](CCCNC(=N)N)C(=O)N3CCCCC3C(=O)O)ccc2c1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCP(=O)(CO)CCC.CCN(CC)CC.CCOC(C)=O.Cc1cccc(Cl)c1S(=O)(=O)Cl.ClCCl>>CCCP(=O)(CCC)COS(=O)(=O)c1c(C)cccc1Cl",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C=CCCc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc(-c2noc(=O)[nH]2)c(Cl)c1.O.OO.[Na+].[OH-]>>O=c1[nH]c(-c2ccc(OCc3sc(-c4ccc(C(F)(F)F)cc4)nc3CCCCO)cc2Cl)no1",
        "output": "465"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)c1cccc(O)c1.Cl.NOCc1ccc([N+](=O)[O-])cc1>>C/C(=N\\OCc1ccc([N+](=O)[O-])cc1)c1cccc(O)c1",
        "output": "212"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCc1nc(C)n(-c2ccc(C(C)(C)O)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1nc(C)n(-c2ccc(C(C)(C)O)cc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC1CN(C(c2ccc(F)cc2)c2ccc(F)cc2)CCN1.CCOC(C)=O.CN(C)C=O.Cc1cc(C)c(NC(=O)CCl)c(C)c1.O=C([O-])[O-].[K+].[K+]>>Cc1cc(C)c(NC(=O)CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2C)c(C)c1",
        "output": "340"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(=O)Cl.CN(C)C=O.Nc1ncc(Sc2ccc([N+](=O)[O-])cc2)s1.O=C([O-])O.[Na+].c1ccncc1>>CCC(=O)Nc1ncc(Sc2ccc([N+](=O)[O-])cc2)s1",
        "output": "553"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCCN1CCNCC1>>CS(=O)(=O)N1CCN(CCO)CC1",
        "output": "584"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.O.OCC(O)C(c1ccccc1)n1ccc2ccccc21.c1ccncc1>>Cc1ccc(S(=O)(=O)OCC(O)C(c2ccccc2)n2ccc3ccccc32)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC(C)(C)C)cc1C(=O)O.F[P-](F)(F)(F)(F)F.NCCc1ccccc1>>Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC(C)(C)C)cc1C(=O)NCCc1ccccc1",
        "output": "836"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "B#[Ni].CCO.CCOC(=O)c1[nH]nc(C(F)(F)F)c1C(=O)c1ccc(Cl)cc1[N+](=O)[O-].Cl.O>>CCOC(=O)c1[nH]nc(C(F)(F)F)c1C(=O)c1ccc(Cl)cc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CO.COc1cnc(-c2ccc(N)c([N+](=O)[O-])c2)nc1N1CCOCC1.[Pd]>>COc1cnc(-c2ccc(N)c(N)c2)nc1N1CCOCC1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Nc1ccc(-c2ccc(C)cc2N)cc1.Cc1ccc2c(Cl)ccnc2n1>>CC(=O)Nc1ccc(-c2ccc(C)cc2Nc2ccnc3nc(C)ccc23)cc1",
        "output": "922"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COC(=O)Cn1cc(C#N)c(-c2cc(Cl)cc([N+](=O)[O-])c2)c1.Cl[Sn]Cl.O=C([O-])O.[Na+]>>COC(=O)Cn1cc(C#N)c(-c2cc(N)cc(Cl)c2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Clc1ccc(CBr)cc1.Nc1ccccc1N.O=C([O-])[O-].[K+].[K+]>>Nc1ccccc1NCc1ccc(Cl)cc1",
        "output": "272"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCC(C(=O)OC)c1c(C)nc(N2CC(C)CC(C)C2)nc1-c1ccc(C)cc1.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc(N2CC(C)CC(C)C2)nc1-c1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(Br)ccc1C(=O)c1cc(-n2cc(CCO)nn2)ccc1C.Cc1cc(Nc2ccc(F)cc2F)ccc1C(=O)c1cc(-n2cc(CCO)nn2)ccc1C.Cc1ccc(N)cc1C>>Cc1ccc(Nc2ccc(C(=O)c3cc(-n4cc(CCO)nn4)ccc3C)c(C)c2)cc1C",
        "output": "405"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)OB(c2cnc(N)nc2)OC1(C)C.O=S(=O)(C1CC1)N1CCN(Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1>>Nc1ncc(-c2nc(N3CCOCC3)c3sc(CN4CCN(S(=O)(=O)C5CC5)CC4)cc3n2)cn1",
        "output": "973"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)CC1OB(O)c2cc(Oc3nncs3)cc(C)c21.Cl.O.O.[Li+].[OH-]>>Cc1cc(Oc2nncs2)cc2c1C(CC(=O)O)OB2O",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.Cl.Cl.NC1CCN(CCN2CCCCCC2)CC1.O=C(O)c1cc2c(OCC3CC3)cccc2[nH]1>>O=C(NC1CCN(CCN2CCCCCC2)CC1)c1cc2c(OCC3CC3)cccc2[nH]1",
        "output": "137"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=Cc1ccc(CCl)cc1.CS(C)=O.O.[C-]#N.[K+]>>C=Cc1ccc(CC#N)cc1",
        "output": "38"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1ccc(Cl)cc1.O=Cc1ccc(Cl)cc1>>O=C(C=Cc1ccc(Cl)cc1)c1ccc(Cl)cc1",
        "output": "295"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc(NC(=O)OC(C)(C)C)ccc1-n1ccnc1.ClCCl.O=C(O)C(F)(F)F>>COc1cc(N)ccc1-n1ccnc1",
        "output": "782"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-c2ccc(OC)nc2)cc1[N+](=O)[O-].Cl.O.O.[Li+].[OH-]>>COc1ccc(-c2ccc(C(=O)O)c([N+](=O)[O-])c2)cn1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)CN.Cc1cc(F)ccc1C(C/C(=N\\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1.Cl>>COC(=O)CNC(=O)c1ccc(-c2ccc(C(C/C(=N\\O)c3ccc(=O)n(C)c3)c3ccc(F)cc3C)cc2)cc1",
        "output": "652"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.O=C(OO)c1cccc(Cl)c1.O=C1N(c2ccccc2Cl)Cc2cnc(SCc3ccccc3)nc2N1C1CCNCC1.O=S([O-])([O-])=S.[Na+].[Na+]>>O=C1N(c2ccccc2Cl)Cc2cnc(S(=O)Cc3ccccc3)nc2N1C1CCNCC1",
        "output": "595"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)CC(O)(c1ccc(Br)cc1)c1cccnc1.CCOCC.Cl.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>OCCC(O)(c1ccc(Br)cc1)c1cccnc1",
        "output": "225"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.Cc1cc(N)ccc1-c1ccc(C(=O)O)cc1.ClCCl.O.O=C(Cl)CCl>>Cc1cc(NC(=O)CCl)ccc1-c1ccc(C(=O)O)cc1",
        "output": "9"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCN(CC)CC.CN(C)c1ccncc1.Cl.Nc1ccn(Cc2cccc(F)c2)c(=O)c1Br.O=C(Cl)c1c(F)cccc1F.[Na+].[OH-]>>O=C(Nc1ccn(Cc2cccc(F)c2)c(=O)c1Br)c1c(F)cccc1F",
        "output": "11"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COC(=O)c1sc(C)nc1-c1ccc(F)cc1.O.[K+].[OH-]>>Cc1nc(-c2ccc(F)cc2)c(C(=O)O)s1",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CCCN.CCOCC.O=C=NCCCl>>C#CCCNC(=O)NCCCl",
        "output": "244"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C)(C)c1ccc(Oc2ccccc2C(=O)OC)c(C(C)(C)CC)c1.CCO.CCOCC.[K+].[OH-]>>CCC(C)(C)c1ccc(Oc2ccccc2C(=O)O)c(C(C)(C)CC)c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CBr.CN1CCCC1=O.CS(=O)(=O)c1c[nH]c2cc(Cl)ccc12.[H-].[Na+]>>CCOC(=O)Cn1cc(S(C)(=O)=O)c2ccc(Cl)cc21",
        "output": "310"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCN(C2CCNCC2)CC1.CCN(CC)CC.CO.COC(=O)C(Cc1ccc(OCc2ccccc2)nc1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1.O.O.O=[PH2]Cl.[Li+].[OH-]>>O=C(NC(Cc1ccc(OCc2ccccc2)nc1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1",
        "output": "227"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COC1CCNCC1.O=C(O)c1cc(F)cc(Cc2n[nH]c(=O)c3cccc(Cl)c23)c1>>COC1CCN(C(=O)c2cc(F)cc(Cc3n[nH]c(=O)c4cccc(Cl)c34)c2)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCCCCCCCCCCCNc1ccc(CCC(=O)OCC)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCCCCCCCCCCCCCCNc1ccc(CCCO)cc1",
        "output": "225"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOCC.CN(C)C(=O)C1CC1(c1ccccc1)c1cccc(Cl)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CN(C)CC1CC1(c1ccccc1)c1cccc(Cl)c1",
        "output": "112"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C=CC(=O)Cl.CCN(C(C)C)C(C)C.CCOC(C)=O.NC1CCN(S(=O)(=O)c2ccc3c(c2)CCN3C(=O)C2CC2)CC1>>C=CC(=O)NC1CCN(S(=O)(=O)c2ccc3c(c2)CCN3C(=O)C2CC2)CC1",
        "output": "298"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1c(Br)ccc2c1CC(=O)N2C.CS(C)=O.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1c(B2OC(C)(C)C(C)(C)O2)ccc2c1CC(=O)N2C",
        "output": "942"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cc(OC2CN(C(=O)OC(C)(C)C)C2)cc([N+](=O)[O-])c1C.[Pd]>>COC(=O)c1cc(OC2CN(C(=O)OC(C)(C)C)C2)cc(N)c1C",
        "output": "481"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCCOc1cccc2[nH]ccc12.c1ccc2ncc(C3CCNCC3)cc2c1>>c1ccc2ncc(C3CCN(CCCOc4cccc5[nH]ccc45)CC3)cc2c1",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN=C=NCCCN(C)C.Cl.Nc1ccc(C(F)(F)F)cc1.O=C(O)c1ncccc1Cl.O=C([O-])O.On1nnc2ccccc21.[Na+].c1ccncc1>>O=C(Nc1ccc(C(F)(F)F)cc1)c1ncccc1Cl",
        "output": "548"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.ClCc1cccc(-c2ccc(Cl)cc2)n1.O.Oc1ccc(CCCCn2ccnn2)cc1.[H-].[Na+]>>Clc1ccc(-c2cccc(COc3ccc(CCCCn4ccnn4)cc3)n2)cc1",
        "output": "616"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)CCCO.O=C1C(Br)=C(c2ccccc2)c2ccc(O)cc21.O=C1C(c2cccnc2)=C(c2ccccc2)c2ccc(O)cc21>>CN(C)CCCOc1ccc2c(c1)C(=O)C(c1cccnc1)=C2c1ccccc1",
        "output": "550"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1c(C(=O)NC)c2ccc(O)cc2n1C.Cn1ccnc1-c1cc2nccc(Cl)c2s1.O=C([O-])[O-].[Cs+].[Cs+]>>CCc1c(C(=O)NC)c2ccc(Oc3ccnc4cc(-c5nccn5C)sc34)cc2n1C",
        "output": "936"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.COc1cc(C(F)(F)F)ccc1-c1ncnc2cc(S(=O)(=O)Cl)ccc12.Cn1ccnc1.Nc1nccs1>>COc1cc(C(F)(F)F)ccc1-c1ncnc2cc(S(=O)(=O)Nc3nccs3)ccc12",
        "output": "637"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COc1ccc(F)c([C@H]2O[C@H](CCO)c3cccn3-c3ccc(Cl)cc32)c1OC.CS(=O)(=O)Cl.ClCCl>>COc1ccc(F)c([C@H]2O[C@H](CCOS(C)(=O)=O)c3cccn3-c3ccc(Cl)cc32)c1OC",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(Oc2ccc(C(=O)NC(Cc3ccc(OC(F)(F)F)cc3)C(=O)O)cc2)cc1.NCCO>>COc1ccc(Oc2ccc(C(=O)NC(Cc3ccc(OC(F)(F)F)cc3)C(=O)NCCO)cc2)cc1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1cc(-n2cc(NC(N)=O)c(C(N)=O)n2)ccc1I.Fc1cccc(S)c1.OCCO.[Cu]I>>Cc1cc(-n2cc(NC(N)=O)c(C(N)=O)n2)ccc1Sc1cccc(F)c1",
        "output": "565"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO.COC(=O)[C@H]1C[C@H](OS(C)(=O)=O)CN1C(=O)OC(C)(C)C.[BH4-].[Na+]>>CC(C)(C)OC(=O)N1C[C@@H](OS(C)(=O)=O)C[C@@H]1CO",
        "output": "430"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.COCc1ccc(C(=O)O)c(N)n1.F[P-](F)(F)(F)(F)F.NCc1cccc(Oc2ccc(C(F)(F)F)cc2)c1.O>>COCc1ccc(C(=O)NCc2cccc(Oc3ccc(C(F)(F)F)cc3)c2)c(N)n1",
        "output": "790"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CC[O-].COc1cc(Br)cnc1Cl.COc1cncc(Br)c1.O.[Na+]>>CCOc1ncc(Br)cc1OC",
        "output": "433"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNC1.CCOC(=O)C(F)(F)Br.N#N>>O=C(N1CCCC1)C(F)(F)Br",
        "output": "494"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)c1cc(CCC(=O)O)cc(C(C)(C)C)c1O.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.OCc1ccccc1>>CC(C)(C)c1cc(CCC(=O)OCc2ccccc2)cc(C(C)(C)C)c1O",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)CC(=O)O.Cl.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1>>CC(C)(C)CC(=O)N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN.ClCCC(c1ccccc1)n1ccc2ccccc21.O.[I-].[Na+]>>CNCCC(c1ccccc1)n1ccc2ccccc21",
        "output": "279"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#Cc1csc(N)c1C(=O)OCC.CC#N.CC(C)NC(C)C.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.I[Cu]I.Ic1ccccc1>>CCOC(=O)c1c(C#Cc2ccccc2)csc1N",
        "output": "664"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CN(C)CCCCCCO.COc1ccccc1CCl.O.[H-].[Na+]>>COc1ccccc1COCCCCCCN(C)C",
        "output": "208"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(COCCO)c1cccc(Cl)c1.CCN(CC)CC.CS(=O)(=O)Cl.Cl.ClCCl>>CC(=O)OC(COCCOS(C)(=O)=O)c1cccc(Cl)c1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(=O)OC(C)=O.Nc1ccc(Cl)c(O)c1>>CC(=O)Nc1ccc(Cl)c(O)c1",
        "output": "6"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC[C@H]1COCc2nc3c(N)nc4ccccc4c3n21.CCO.Cl>>NC[C@H]1COCc2nc3c(N)nc4ccccc4c3n21",
        "output": "538"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.COc1ccc2[nH]cc(C=O)c2c1.O=C([O-])O.[H-].[Na+].[Na+]>>COc1ccc2c(c1)c(C=O)cn2C",
        "output": "191"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1ccc(C(=O)O)cc1O.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)CC[C@@H]1NCCC[C@H]21>>Cc1ccc(C(=O)N2CCC[C@@H]3c4ccccc4CC[C@@H]32)cc1O",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(=O)(=O)c1cccnc1Cl.N>>CS(=O)(=O)c1cccnc1N",
        "output": "388"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)COc1ccc(Cn2nnc(-c3cccc(C#CCc4ccc(F)cc4)c3)n2)cc1.O=C(O)C(F)(F)F>>O=C(O)COc1ccc(Cn2nnc(-c3cccc(C#CCc4ccc(F)cc4)c3)n2)cc1",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)CC(C)C.ClCCCC(c1ccc(Cl)cc1)c1ccc(Cl)cc1.O.O=C([O-])[O-].O=c1[nH]c2cc(Cl)ccc2n1C1CCNCC1.[Na+].[Na+]>>O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCC(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CC1",
        "output": "138"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "N#Cc1ccc(N(Cc2ccccc2Cl)[C@H]2CCNC2)cc1Cl.O=S(=O)(Cl)c1ccc(-c2ccccn2)s1>>N#Cc1ccc(N(Cc2ccccc2Cl)[C@H]2CCN(S(=O)(=O)c3ccc(-c4ccccn4)s3)C2)cc1Cl",
        "output": "798"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)O[K].CC(C)(O)CCO.CCc1c(Cn2ccnc2-c2nccs2)nc2ccc(Cl)nn12>>CCc1c(Cn2ccnc2-c2nccs2)nc2ccc(OCCC(C)(C)O)nn12",
        "output": "407"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CCOc1ccc(-c2nc(CCC(=O)c3ccccc3C(=O)O)cs2)cc1OCC.CN(C)C=O.CNC.O.On1nnc2ccccc21>>CCOc1ccc(-c2nc(CCC(=O)c3ccccc3C(=O)N(C)C)cs2)cc1OCC",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1nc2ccc(NC(=O)C(CC)n3cc(OC)c(-c4cc(Cl)ccc4C#N)cc3=O)cc2[nH]1.[Li+].[OH-]>>CCC(C(=O)Nc1ccc2nc(C(=O)O)[nH]c2c1)n1cc(OC)c(-c2cc(Cl)ccc2C#N)cc1=O",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc2cc(Nc3cc(C)[nH]n3)nc(Cl)c2cc1OC.Oc1ccc(F)cc1>>COc1cc2cc(Nc3cc(C)[nH]n3)nc(Oc3ccc(F)cc3)c2cc1OC",
        "output": "516"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CO.Cc1cc([N+](=O)[O-])cnc1N1CCOCC1.Cl.[H][H].[Pd]>>Cc1cc(N)cnc1N1CCOCC1",
        "output": "269"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)O.CC(C)(C)[O-].Cc1ccnc(Br)c1.O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(c2nccnc2Cl)CC1.OCc1ccnc(Br)c1.[K+]>>O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(c2nccnc2OCc2ccnc(Br)c2)CC1",
        "output": "209"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.CC(C)(C)c1cc(NC(=O)Nc2cccc(Cl)c2Cl)n(-c2ccc3c(c2)CNCC3)n1.CCN(CC)CC.ClCCl>>CC(=O)N1CCc2ccc(-n3nc(C(C)(C)C)cc3NC(=O)Nc3cccc(Cl)c3Cl)cc2C1",
        "output": "240"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=C(O)c1ccnnc1.O=S(=O)(O)O>>COC(=O)c1ccnnc1",
        "output": "521"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCCn1c([C@@H](C)OCc2ccccc2)nn(Cc2ccc(C)cc2)c1=O.CCO.[Pd]>>CCCn1c([C@@H](C)O)nn(Cc2ccc(C)cc2)c1=O",
        "output": "178"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(Nc2c([N+](=O)[O-])cnc3c2ccn3S(=O)(=O)c2ccccc2)CCCN(C(=O)OCc2ccccc2)C1.CCOC(C)=O.[Ni]>>CC1(Nc2c(N)cnc3c2ccn3S(=O)(=O)c2ccccc2)CCCN(C(=O)OCc2ccccc2)C1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.CNCCOc1cc(C)ccc1C(C)C.Cc1c(C)c(OCCO)c(CCl)c(C)c1O>>Cc1ccc(C(C)C)c(OCCN(C)Cc2c(C)c(O)c(C)c(C)c2OCCO)c1",
        "output": "156"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(CC)CC.NCCc1ccc(F)cc1.O=S(=O)(Cl)c1ccc(Br)s1>>O=S(=O)(NCCc1ccc(F)cc1)c1ccc(Br)s1",
        "output": "600"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=[N+]([O-])c1cc(Cl)cc(Cl)c1O.O=[Pt].[H][H]>>Nc1cc(Cl)cc(Cl)c1O",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.ClCCl.Clc1cccc(-c2cc([C@H]3CC[C@H]4CNCCN43)no2)c1>>CCOC(=O)N1CCN2[C@@H](CC[C@@H]2c2cc(-c3cccc(Cl)c3)on2)C1",
        "output": "219"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1cc(OCCCN2CCCCC2)ccc1N1CCNCC1.CCN(CC)CC.ClCCl.O=C(Cl)c1cccc2ccccc12>>O=C(c1cccc2ccccc12)N1CCN(c2ccc(OCCCN3CCCCC3)cc2Br)CC1",
        "output": "201"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(=O)Cl.CCc1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)N[C@@H]4CC[C@@H](N)CC4)c(C)[nH]c23)c1.Cl>>CCC(=O)N[C@@H]1CC[C@@H](NC(=O)c2c(C)[nH]c3c(-c4cc(CC)ccc4OCC4CC4)ncnc23)CC1",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Fc1ccc2c(C3CCC4(CC3)OCCO4)c[nH]c2c1.O=C1CCC(c2c[nH]c3ccc(F)cc23)CC1>>O=C1CCC(c2c[nH]c3cc(F)ccc23)CC1",
        "output": "251"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc([N+](=O)[O-])c(OC(C)C)c1.[Li+].[OH-]>>CC(C)Oc1cc(C(=O)O)ccc1[N+](=O)[O-]",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CO.COC(=O)[C@H](C)Oc1ccc(F)c2nc(OC(F)F)c(Cc3ccc(Cl)cc3Cl)c(C)c12.O.[Li+].[OH-]>>Cc1c(Cc2ccc(Cl)cc2Cl)c(OC(F)F)nc2c(F)ccc(O[C@@H](C)C(=O)O)c12",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCNC(=O)NCc1cccc([N+](=O)[O-])c1.CCO.[H][H].[Pd]>>CCNC(=O)NCc1cccc(N)c1",
        "output": "71"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Cc1nc2c(cc1C(=O)NC(=N)N)C(O[Si](C)(C)C(C)(C)C)CCCC2.Cl>>Cc1nc2c(cc1C(=O)NC(=N)N)C(O)CCCC2",
        "output": "708"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.Cc1cc(O)c(Cl)c(=O)n1-c1c(F)cccc1F.Fc1ccc(CBr)c(F)c1.O.O=C([O-])[O-].[K+].[K+]>>Cc1cc(OCc2ccc(F)cc2F)c(Cl)c(=O)n1-c1c(F)cccc1F",
        "output": "127"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=Cc1ccc(F)c(C(=O)O)c1.c1cnc(N[C@H]2CCNC2)nc1>>O=Cc1ccc(F)c(C(=O)N2CC[C@H](Nc3ncccn3)C2)c1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)NCc1cccc(Br)c1.CC(C)C(O)(c1ccc(B(O)O)cc1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CC(=O)NCc1cccc(-c2ccc(C(O)(c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)C(C)C)cc2)c1",
        "output": "908"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc(OC(=O)C2CCc3ccccc32)cc1OC.O.O.[Li]O>>COc1cc(OC(=O)C2CCc3ccccc32)ccc1C(=O)O",
        "output": "222"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.O=C(CCc1ccc([N+](=O)[O-])cc1)CCc1ccc([N+](=O)[O-])cc1.[H][H].[Pd]>>Nc1ccc(CCC(=O)CCc2ccc(N)cc2)cc1",
        "output": "204"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=C(O)Cc1ccc([N+](=O)[O-])cc1C(=O)O.[Br-].[H][H].[K+].[Na+].[OH-].[Pd]>>Nc1ccc(CC(=O)O)c(C(=O)O)c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CS(=O)(=O)c1ccccc1B(O)O.Cl[Pd]Cl.NC(=O)c1ccc2cncc(Br)c2n1.O.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CS(=O)(=O)c1ccccc1-c1cncc2ccc(C(N)=O)nc12",
        "output": "871"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrP(Br)Br.C1CCOC1.O=C([O-])O.OCc1c(Cl)cc(OCc2ccccc2)cc1Cl.[Na+]>>Clc1cc(OCc2ccccc2)cc(Cl)c1CBr",
        "output": "300"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCn1cc(-c2ccnc3c2ccn3S(=O)(=O)c2ccc(C)cc2)c(-c2cccc([N+](=O)[O-])c2)n1.CN(C)C=O.CO.ClCCl.[Na+].[OH-]>>CCn1cc(-c2ccnc3[nH]ccc23)c(-c2cccc([N+](=O)[O-])c2)n1",
        "output": "949"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CNC(=O)c1cc([N+](=O)[O-])c[nH]1.CO>>CNC(=O)c1cc(N)c[nH]1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCCCSc1ccccn1>>COc1cc2ncnc(Oc3ccc(NC(=O)OCCCSc4ccccn4)cc3)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.C1COCCOCCOCCOCCOCCO1.CC(C)(C)[O-].CCOCC.Clc1ccc2[nH]ccc2c1.O.[K+]>>Clc1ccc2c(ccn2Cc2ccccc2)c1",
        "output": "528"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.Cl.Cl.ClCCl.O=C(O)c1ccc2c(-c3ccnc(NC4CCCC4)n3)c(-c3ccc(F)cc3)nn2c1NC1CCCC1.O=S(Cl)Cl>>O=C(c1ccc2c(-c3ccnc(NC4CCCC4)n3)c(-c3ccc(F)cc3)nn2c1NC1CCCC1)N1CCCC1",
        "output": "256"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)[Si](Cl)(C(C)C)C(C)C.CN(C)C=O.C[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O.c1c[nH]cn1>>CC(C)[Si](O[C@@H]1[C@H](O)[C@@H](C)O[C@H]1n1cnc2c(N)nc(Cl)nc21)(C(C)C)C(C)C",
        "output": "193"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C[O-].[NH4+].c1ccc(CN[C@H]2CC[C@@H](c3c[nH]c4ccccc34)C2)cc1>>N[C@H]1CC[C@@H](c2c[nH]c3ccccc23)C1",
        "output": "561"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1cc(N)cc(C(C)(C)C)c1O.CS(=O)(=O)Cl.ClC(Cl)Cl.[Na+].[OH-]>>CC(C)(C)c1cc(NS(C)(=O)=O)cc(C(C)(C)C)c1O",
        "output": "194"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClCc1ccccc1.O=C([O-])[O-].Oc1c(F)cc(Br)cc1F.[K+].[K+]>>Fc1cc(Br)cc(F)c1OCc1ccccc1",
        "output": "49"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Clc1nc(Cl)nc(Cl)n1.Nc1cc(S(=O)(=O)O)cc2cc(S(=O)(=O)O)cc(O)c12.O>>O=S(=O)(O)c1cc(O)c2c(Nc3nc(Cl)nc(Cl)n3)cc(S(=O)(=O)O)cc2c1",
        "output": "592"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Cc1c(Cl)cccc1C(=O)O.Cl>>Cc1c(Cl)cccc1CO",
        "output": "72"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NC(=O)c1cc(-c2cccnc2[C@@H](N)Cc2cc(F)cc(F)c2)ccc1F.O=C(O)C(F)(F)F.O=C(O)Cc1c[nH]c2ccc(Br)cc12>>NC(=O)c1cc(-c2cccnc2[C@H](Cc2cc(F)cc(F)c2)NC(=O)Cc2c[nH]c3ccc(Br)cc23)ccc1F",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1nc(CC(=O)N2CCN(CC(=O)N3CCCC3)CC2)cs1.O=C(O)c1ccc2c(c1)CCO2>>O=C(Nc1nc(CC(=O)N2CCN(CC(=O)N3CCCC3)CC2)cs1)c1ccc2c(c1)CCO2",
        "output": "918"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCC1CC1.CC(C)=O.O=C([O-])[O-].OCCOc1ccccc1O.[K+].[K+]>>OCCOc1ccccc1OCC1CC1",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(C(C)C)C(C)C.Nc1cccc(-c2noc([C@H]3CCCCN3C(=O)COc3ccccc3)n2)c1.O>>CC(=O)Nc1cccc(-c2noc([C@H]3CCCCN3C(=O)COc3ccccc3)n2)c1",
        "output": "9"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc2c(OCC(=O)O)ccnc2c1.NNc1ncc(-c2ccc([N+](=O)[O-])cc2)nn1.NNc1ncc(-c2ccccc2)nn1.O=C(O)Cc1ccc2ncccc2c1>>COc1ccc2c(OCC(=O)NNc3ncc(-c4ccc([N+](=O)[O-])cc4)nn3)ccnc2c1",
        "output": "459"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.CCOC(C)=O.CN(C)c1ccncc1.CNc1ccc([N+](=O)[O-])cc1>>CC(=O)N(C)c1ccc([N+](=O)[O-])cc1",
        "output": "160"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(-c2ccn(-c3ccc4c5c(n(C)c4c3)CCN(C(=O)OC(C)(C)C)C5)c(=O)c2)cc1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(-c2ccn(-c3ccc4c5c(n(C)c4c3)CCNC5)c(=O)c2)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)c1ccccc1-c1ccc(CBr)cc1",
        "output": "29"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNc1cc([N+](=O)[O-])ccc1O.CO.O.O=C([O-])[O-].[Cl-].[K+].[K+].[NH4+]>>CN(C(=O)OC(C)(C)C)c1cc([N+](=O)[O-])ccc1O",
        "output": "827"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.Nc1cc(Cl)c(Sc2ccc3ccccc3c2)c(Cl)c1.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1Cl.c1ccncc1>>O=S(=O)(Nc1cc(Cl)c(Sc2ccc3ccccc3c2)c(Cl)c1)c1ccc(C(F)(F)F)cc1Cl",
        "output": "68"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CS(C)=O.N#Cc1cc(Cl)cc(Oc2c(Br)ccc(CBr)c2F)c1.[N-]=[N+]=[N-].[Na+]>>N#Cc1cc(Cl)cc(Oc2c(Br)ccc(CN=[N+]=[N-])c2F)c1",
        "output": "643"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC.COc1cc2ncnc(Oc3ccc(CC(=O)O)cc3)c2cc1OC.Cc1cc(N)[nH]n1.Cl.[O-][n+]1ccccc1O>>COc1cc2ncnc(Oc3ccc(CC(=O)Nc4cc(C)n[nH]4)cc3)c2cc1OC",
        "output": "795"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNCC1.CCO.Cc1[nH]c(C=O)c(C)c1C(=O)N1CCN(C)CC1.O=C1Cc2c(cccc2-c2cccc(Cl)c2)N1>>Cc1[nH]c(C=C2C(=O)Nc3cccc(-c4cccc(Cl)c4)c32)c(C)c1C(=O)N1CCN(C)CC1",
        "output": "440"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCc2ccc(C(=O)NCc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)cc2C1.CCOCC.Cl.ClCCl>>O=C1CCC(N2Cc3cc(CNC(=O)c4ccc5c(c4)CNCC5)ccc3C2=O)C(=O)N1",
        "output": "887"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1cccc(C)c1.ClCCl.[Cl-].[Cl-].[Li+].[OH-].[Ru+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cccc(C(C)O)c1",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)Cc1ccc(O)c(C=O)c1.O=C1CCC(=O)N1Br>>COC(=O)Cc1cc(Br)c(O)c(C=O)c1",
        "output": "4"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COS(=O)(=O)OC.Cc1c(OCc2ccccc2)ccc(C=O)c1O.O.[Na+].[OH-]>>COc1c(C=O)ccc(OCc2ccccc2)c1C",
        "output": "317"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)CC1(O)CCc2ccc(F)cc21.[Na+].[OH-]>>O=C(O)CC1(O)CCc2ccc(F)cc21",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCS(=O)(=O)c1ccc(Oc2cc(C(C)C(=O)O)cc(C(F)(F)F)c2)c(Cl)c1.CCS(N)(=O)=O>>CCS(=O)(=O)NC(=O)C(C)c1cc(Oc2ccc(S(=O)(=O)CC)cc2Cl)cc(C(F)(F)F)c1",
        "output": "644"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCc1nc2c(C)cc(-c3cn(C(C)OCCOC)cn3)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCCc1nc2c(C)cc(-c3cn(C(C)OCCOC)cn3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(Cl)OC(=O)Cl.ClCCCl.O=S(=O)(c1cc(Cl)cc(Cl)c1)n1ccc2c(N3CCN(Cc4ccccc4)CC3)cccc21>>O=S(=O)(c1cc(Cl)cc(Cl)c1)n1ccc2c(N3CCNCC3)cccc21",
        "output": "84"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCN1Cc2nc3c(Br)cccc3c(N)c2C1=O.COc1ccc(B(O)O)c(OC)n1>>CCCN1Cc2nc3c(-c4ccc(OC)nc4OC)cccc3c(N)c2C1=O",
        "output": "883"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1n[nH]c2c1CCCC2.CO.[Na+].[OH-]>>O=C(O)c1n[nH]c2c1CCCC2",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.O=C(O)c1cc2c(F)cccc2[nH]1.On1nnc2ccccc21.[Cl-].[NH4+]>>NC(=O)c1cc2c(F)cccc2[nH]1",
        "output": "136"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCOC(=O)COc1ccc(C=Cc2ccccc2)cc1.Cl.[Na+].[OH-]>>O=C(O)COc1ccc(C=Cc2ccccc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.Cc1ccc(Oc2ccccc2)cc1N.Cl.ClCCl.c1ccncc1>>CC(=O)Nc1cc(Oc2ccccc2)ccc1C",
        "output": "6"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Nc1ncnc2c1nc(NCc1ccc(-c3cccc(OCc4ccccc4)c3)cc1)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O.[Pd]>>Nc1ncnc2c1nc(NCc1ccc(-c3cccc(O)c3)cc1)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O",
        "output": "23"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.CN(C)C=O.C[C@@H]1COCCN1c1nc(-c2ccc(NC(=O)NC3CC3)cc2F)nc2c1CNC2.Cl>>CCOC(=O)N1Cc2nc(-c3ccc(NC(=O)NC4CC4)cc3F)nc(N3CCOC[C@H]3C)c2C1",
        "output": "219"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CSc1cnc(N)s1.CCOC(=O)CSc1cnc(NC(=O)N(CC2CCCC2)c2ccc(OC)c(F)c2F)s1.COc1ccc(NCC2CCCC2)c(F)c1F.CS(=O)(=O)c1ccc(N(CC2CCCC2)C(=O)Nc2nc(CC(=O)O)cs2)cc1>>COc1ccc(N(CC2CCCC2)C(=O)Nc2ncc(SCC(=O)O)s2)c(F)c1F",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC1(C)c2ccccc2-c2cc3c(cc21)[nH]c1ccccc13.CC1(C)c2ccccc2-c2cc3c4cc(Br)ccc4n(-c4nc(-c5ccccc5)nc(-c5ccccc5)n4)c3cc21.Cc1ccc(C)cc1.[Pd+2]>>CC1(C)c2ccccc2-c2cc3c4ccccc4n(-c4ccc5c(c4)c4cc6c(cc4n5-c4nc(-c5ccccc5)nc(-c5ccccc5)n4)C(C)(C)c4ccccc4-6)c3cc21",
        "output": "349"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "FC(F)(F)C1CNCCN1.O=C(O)c1cn(C2CC2)c2cc(F)c(F)cc2c1=O.c1ccncc1>>O=C(O)c1cn(C2CC2)c2cc(N3CCNC(C(F)(F)F)C3)c(F)cc2c1=O",
        "output": "676"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc(N)cc1-n1ccn2nc(-c3cncs3)cc12.F[P-](F)(F)(F)(F)F.O=C(O)c1cccc(S(F)(F)(F)(F)F)c1>>Cc1ccc(NC(=O)c2cccc(S(F)(F)(F)(F)F)c2)cc1-n1ccn2nc(-c3cncs3)cc12",
        "output": "50"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)C(CC1CCCC1)c1ccc(S(C)(=O)=O)c(C(F)(F)F)c1.O.[Li+].[OH-]>>CS(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)O)cc1C(F)(F)F",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.C[C@H]1Cn2ncc(N3C(=O)OC[C@H]3c3ccccc3)c2CN1.O=C(Nc1cc(F)c(F)c(F)c1)Oc1ccccc1>>C[C@H]1Cn2ncc(N3C(=O)OC[C@H]3c3ccccc3)c2CN1C(=O)Nc1cc(F)c(F)c(F)c1",
        "output": "525"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCN1CCC(C(N)=O)CC1.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+].[Na+].[OH-]>>CCCN1CCC(CN)CC1",
        "output": "112"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NCC1CN(c2ncnc3[nH]c4ccccc4c23)CCO1.CO.Cl>>NCC1CN(c2ncnc3[nH]c4ccccc4c23)CCO1",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1.Cc1ccccc1.Cc1nc(Br)ccc1F.O.[Na+]>>Cc1nc(N2CCN(C(=O)OC(C)(C)C)C[C@H]2C)ccc1F",
        "output": "647"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=CCC(CCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)OCC.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>C=CCC(CCO)OCC",
        "output": "781"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC1(C)CCC(C)(C)c2cc([Se]C#Cc3ccc(C(=O)O)cc3)ccc21.CCN=C=NCCCN(C)C.CCOC(C)=O.Nc1ccc(O)cc1.O.On1nnc2ccccc21>>CC1(C)CCC(C)(C)c2cc([Se]C#Cc3ccc(C(=O)Nc4ccc(O)cc4)cc3)ccc21",
        "output": "50"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccc(-c2cccc3c2oc2ccccc23)cc1.[Pd]>>Nc1ccc(-c2cccc3c2oc2ccccc23)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)NC1Cc2ccccc2C1.ClCCl.O=S(=O)(O)Cl>>CC(=O)NC1Cc2ccc(S(=O)(=O)Cl)cc2C1",
        "output": "182"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NC1(c2ccc(-c3oc4cnccc4c3I)cc2)CCC1.NC1(c2ccc(-c3oc4ccncc4c3-c3ccccc3)cc2)CCC1>>NC1(c2ccc(-c3oc4cnccc4c3I)cc2)CCC1",
        "output": "793"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(O)C1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2Br)C1.OB(O)c1cccnc1>>CC(C)(O)C1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cccnc2)C1",
        "output": "883"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Br.CC(=O)O.CCOC(C)=O.COc1ccc(C)cc1C1CC(C)(C)CC(C)(C)C1.O=C([O-])O.[Na+]>>Cc1ccc(O)c(C2CC(C)(C)CC(C)(C)C2)c1",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCC(CC)c1nn(-c2ccc(Cl)cn2)cc1CCCO.CCCCP(CCCC)CCCC.COC(=O)Cc1cccc(C)c1O.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CCC(CC)c1nn(-c2ccc(Cl)cn2)cc1CCCOc1c(C)cccc1CC(=O)O",
        "output": "928"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCCCC2c2coc3cccc-3c2)CC1.O=C(O)c1ccc(N2CCS(=O)(=O)CC2)cc1>>O=C(N[C@@H]1CC[C@@H](CCN2CCCCC2c2coc3cccc-3c2)CC1)c1ccc(N2CCS(=O)(=O)CC2)cc1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.O=C1CCC(=O)N1Br.OCCCCCCC1CCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>BrCCCCCCC1CCCC1",
        "output": "581"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCCCCC=C[C@@H]2C[C@@]2(C(=O)NS(=O)(=O)C2CC2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O.CC(C)(C)[O-].CCOC(C)=O.COc1ccc2c(Cl)cc(-c3nc(C4CC4)cs3)nc2c1C.CS(C)=O.[K+]>>COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6CC6)C[C@H]5C=CCCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N4C3)cc(-c3nc(C4CC4)cs3)nc2c1C",
        "output": "651"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)Cc1c(C)[nH]c2ccc(C)cc12.NCCN>>Cc1ccc2[nH]c(C)c(CC(=O)NCCN)c2c1",
        "output": "64"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1CCC(C(C)C)C(O)C1.COC(=O)CN1C(=O)C(=C(C)c2ccccc2)c2ccccc21.O.[Li+].[OH-]>>CC(=C1C(=O)N(CC(=O)O)c2ccccc21)c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1ccc(Cc2nc3c(c4c2[nH]c2ccccc24)C(=O)CC(C)(C)C3)cc1F.ClCCl>>CC1(C)CC(=O)c2c(nc(Cc3ccc(O)c(F)c3)c3[nH]c4ccccc4c23)C1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cc2cc(N)ccc2[nH]1.ClC(Cl)Cl.ClCCl.O=S(=O)(Cl)CCCCl.c1ccncc1>>CCOC(=O)c1cc2cc(NS(=O)(=O)CCCCl)ccc2[nH]1",
        "output": "194"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)C(=O)O.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.NC1=NS(=O)(=O)Nc2cccc(OC[C@H]3CCCNC3)c21.O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].On1nnc2ccccc21.[Ce+4].[NH4+].[NH4+]>>CC(C)(C)C(=O)N1CCC[C@H](COc2cccc3c2C(N)=NS(=O)(=O)N3)C1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.OCCOCCOCCOCCO>>Cc1ccc(S(=O)(=O)OCCOCCOCCOCCO)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cc1cc(OC(C)C)cc(C)c1C(=O)CBr.NC(N)=S>>Cc1cc(OC(C)C)cc(C)c1-c1csc(N)n1",
        "output": "716"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCC1CCC1.CC(=O)N(C)C.O=c1cc(OCc2ccccc2)cc[nH]1.[H-].[Na+]>>O=c1cc(OCc2ccccc2)ccn1CC1CCC1",
        "output": "470"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#CCCO.CCNCC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cccc(I)c21.I[Cu]I>>Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cccc(C#CCCO)c21",
        "output": "819"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "N#CCBr.O=C([O-])[O-].Oc1ccc2cc(-c3ccc(-c4ccccc4)[nH]3)ccc2c1.[Cs+].[Cs+]>>N#CCOc1ccc2cc(-c3ccc(-c4ccccc4)[nH]3)ccc2c1",
        "output": "802"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.O.O.O=C(O)Cc1ccc(Cl)nc1.O=C([O-])[O-].OB(O)c1cccc(Cl)c1.[Na+].[Na+].[Na+].[OH-]>>O=C(O)Cc1ccc(-c2cccc(Cl)c2)nc1",
        "output": "865"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C(=O)O)c1ccc(Cl)cc1.CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(CO)c1ccc(Cl)cc1",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1ccccn1.C1CCOC1.O=C([O-])[O-].OB(O)c1cccc(Cl)c1.[K+].[K+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Clc1cccc(-c2ccccn2)c1",
        "output": "869"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COCCN(CCN(c1ccc2c(c1)C(=O)N(CC(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC3CC3)c1)C2=O)S(C)(=O)=O)C(=O)OC(C)(C)C.Cl.ClCCl>>COCCNCCN(c1ccc2c(c1)C(=O)N(CC(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC3CC3)c1)C2=O)S(C)(=O)=O",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.NC1CCN(C(=O)C(F)(F)F)CC1.O.O=Cc1ccc2ccc(=O)[nH]c2n1.[Na+]>>O=C(N1CCC(NCc2ccc3ccc(=O)[nH]c3n2)CC1)C(F)(F)F",
        "output": "775"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNC1.CC(C)(C)OC(=O)C1(c2ccc(Br)cc2)CC1.CCC(C)(C)[O-].Cc1ccccc1.ClCCl.[Fe+2].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(C)OC(=O)C1(c2ccc(N3CCCC3)cc2)CC1",
        "output": "294"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CC2(CCNCC2)C1.CCN(C(C)C)C(C)C.CS(C)=O.O=[N+]([O-])c1ccc(F)cc1>>CC(C)(C)OC(=O)N1CC2(CCN(c3ccc([N+](=O)[O-])cc3)CC2)C1",
        "output": "26"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Brc1ccc2cc[nH]c2c1.CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1>>CC(C)(C)OC(=O)n1ccc2ccc(Br)cc21",
        "output": "748"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCOC(C)=O.CN(C)C=O.ClCCl.Cn1nc(-c2cnc3[nH]cc(C(=O)NC4CCCC(O)C4)c3n2)c2ccc(Cl)cc21>>Cn1nc(-c2cnc3[nH]cc(C(=O)NC4CCCC(=O)C4)c3n2)c2ccc(Cl)cc21",
        "output": "87"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1ccc([N+](=O)[O-])c2ccccc12.O.[I-].[Na+]>>O=[N+]([O-])c1ccc(O)c2ccccc12",
        "output": "402"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccccc1Nc1ccc(F)cc1.[Pd]>>Nc1ccccc1Nc1ccc(F)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCN(C(=O)C4(NC(=O)OC(C)(C)C)CC4)CC3)n(C)c2n1.ClCCl.O=C(O)C(F)(F)F>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCN(C(=O)C4(N)CC4)CC3)n(C)c2n1",
        "output": "431"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.CCOC(C)=O.CN(C)C=O.Cc1ccccc1.N#CCBr.O=C([O-])[O-].OCc1cccc(O)c1.[K+].[K+]>>N#CCOc1cccc(CO)c1",
        "output": "802"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)C(c1ccc(C(F)(F)F)cc1)C1CCCC1.Cl.O.[Li+].[OH-]>>O=C(O)C(c1ccc(C(F)(F)F)cc1)C1CCCC1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(S(=O)(=O)Cl)cc1.Cc1cccc(-c2cc(NCCN)nc(N)n2)c1C>>COc1ccc(S(=O)(=O)NCCNc2cc(-c3cccc(C)c3C)nc(N)n2)cc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCOC(=O)C(C)=Cc1ccccc1[N+](=O)[O-].COc1cc(N)c(C=C(C)C(=O)NCCc2ccccc2)cc1OC.O.[Fe]>>CCOC(=O)C(C)=Cc1ccccc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CO.COCc1cc(Br)ccc1C(=O)OC.O.[Na+].[OH-]>>COCc1cc(Br)ccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Cl.CC1(C)C[C@H]2[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)CO1.Cl.ClCCl.c1ccncc1>>CC(=O)Oc1ccc2c(c1)[C@]13CCN(CC4CC4)[C@H](C2)[C@@H]1CC(C)(C)OC3",
        "output": "111"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCCCCCBr.CCOC(=O)CCc1cc(C(=O)c2ccc(C(=O)OCC)cc2)ccc1O>>CCOC(=O)CCc1cc(C(=O)c2ccc(C(=O)OCC)cc2)ccc1OCCCCCBr",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)CC1.Cl.ClCCl>>O=S(=O)(c1ccc(OC(F)(F)F)cc1)N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCCC1=O.COC(=O)/C=C/c1ccc(O)cc1.O.O=C([O-])[O-].OCCCCCCCl.[K+].[K+]>>COC(=O)C=Cc1ccc(OCCCCCCO)cc1",
        "output": "74"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)C1CCCC(CCC2OCCO2)C1.CC(C)=O.ClCCl.Cl[Fe](Cl)Cl.O.O.O.O.O.O>>CC(C)(C)C1CCCC(CCC=O)C1",
        "output": "740"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cl.N#Cc1ccccc1F.NO.O=C([O-])O.[Na+]>>NC(=NO)c1ccccc1F",
        "output": "400"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(CO)CCC2(CC1)OCCO2.ClCCl.[Cr+4].[O-2].[O-2].c1ccncc1>>CC1(C=O)CCC2(CC1)OCCO2",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN.CN(C)C=O.Cl.O.O=C(O)c1ccc2[nH]ccc2c1.On1nnc2ccccc21>>CNC(=O)c1ccc2[nH]ccc2c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(Oc1ccccc1)C(=O)Cl.CCNCc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)OC)ccc1OC>>CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)OC)ccc1OC)C(=O)C(C)Oc1ccccc1",
        "output": "240"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.Cc1c(C(=O)Nc2cnc(N3CCC4(CC3)OCCO4)c(C3CC3)c2)cnn1-c1ccc(Cl)cc1.Cl.O.[Na+].[OH-]>>Cc1c(C(=O)Nc2cnc(N3CCC(=O)CC3)c(C3CC3)c2)cnn1-c1ccc(Cl)cc1",
        "output": "251"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)COC(=O)Cl.CC(N)COc1ccc(C#N)cc1.CC[C@H](NC(=O)OC(C)(C)C)C(=O)O.CN1CCCCC1.ClCCl.O>>CC[C@H](NC(=O)OC(C)(C)C)C(=O)NC(C)COc1ccc(C#N)cc1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOc1cc(CN2CCC(N)CC2)ccc1Cl.Cc1ccc(C(=O)O)c(C)c1>>CCOc1cc(CN2CCC(NC(=O)c3ccc(C)cc3C)CC2)ccc1Cl",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC#Cc1ccc(N)cc1Cl.CO.[Ni]>>CCN(CC)CCCc1ccc(N)cc1Cl",
        "output": "717"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccccc1.ClCCl.O=S(Cl)Cl.OCc1cccc(Oc2ncc(Br)cn2)c1>>ClCc1cccc(Oc2ncc(Br)cn2)c1",
        "output": "81"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1cccc(C#N)c1.NC(=NO)c1ccccc1.NO>>Cc1cccc(C(N)=NO)c1",
        "output": "400"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O[C@@H]1CN(CCNc2ncccn2)CC[C@H]1NCc1ccccc1.[H][H].[Pd]>>N[C@@H]1CCN(CCNc2ncccn2)C[C@H]1O",
        "output": "561"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCOC(C)=O.C[C@@H]1CN(C(=O)[C@@](C)(O)C(F)(F)F)[C@@H](C)CN1.O=S(=O)(Cl)c1ccc(F)cc1>>C[C@H]1CN(S(=O)(=O)c2ccc(F)cc2)[C@H](C)CN1C(=O)[C@@](C)(O)C(F)(F)F",
        "output": "99"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CNC(=O)c1c(-c2ccc(Cl)cc2)oc2cc(N(c3ccc(O)c(F)c3)S(C)(=O)=O)c(C3CC3)cc12.ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CNC(=O)c1c(-c2ccc(Cl)cc2)oc2cc(N(c3ccc(OS(=O)(=O)C(F)(F)F)c(F)c3)S(C)(=O)=O)c(C3CC3)cc12",
        "output": "731"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCN(CCO[Si](C)(C)C(C)(C)C)C(=O)C1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>CC(C)(C)OC(=O)N1CCN(CCO)C(=O)C1",
        "output": "708"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOCOc1ccc(NC(=O)OC(C)(C)C)cc1C=CC(=O)OC.CO.O.O.O=P([O-])([O-])[O-].[Li+].[OH-]>>CCOCOc1ccc(NC(=O)OC(C)(C)C)cc1C=CC(=O)O",
        "output": "58"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CC(C)C[AlH]CC(C)C.CCn1cc(C(=O)O)c(=O)c2ccc(OCc3ccc(OC)cc3)c(OCc3ccc(OC)cc3)c21.Cc1ccccc1>>CCn1cc(CO)c(=O)c2ccc(OCc3ccc(OC)cc3)c(OCc3ccc(OC)cc3)c21",
        "output": "293"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCc1ccc(CC(=O)OC)c(OCc2cccc(-c3cccc(CNC(=O)OC(C)(C)C)c3)c2)c1.CO.Cl.ClCCl.O>>CCc1ccc(CC(=O)O)c(OCc2cccc(-c3cccc(CNC(=O)OC(C)(C)C)c3)c2)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc(F)ccc1-c1nc(S(C)(=O)=O)nc2c1CNC(=O)N2c1c(F)cccc1F.OCCO>>Cc1cc(F)ccc1-c1nc(OCCO)nc2c1CNC(=O)N2c1c(F)cccc1F",
        "output": "667"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.Cc1cc(Br)ccc1CBr.ClCCl.O.[Br-].[C-]#N.[K+]>>Cc1cc(Br)ccc1CC#N",
        "output": "39"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O.O=C(O)C1CNC1.[K+].[OH-]>>CC(C)(C)OC(=O)N1CC(C(=O)O)C1",
        "output": "694"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#C[Si](C)(C)C.CCCCN.CN(C(=O)OC(C)(C)C)c1cc2ccn(-c3ccc([N+](=O)[O-])c(Br)c3)c(=O)c2cc1F.CN(C)C=O.O=[N+]([O-])c1ccc(F)cc1Br.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCCCNc1cc(-n2ccc3cc(N(C)C(=O)OC(C)(C)C)c(F)cc3c2=O)ccc1[N+](=O)[O-]",
        "output": "519"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(c2ccc(Cl)c(C(F)(F)F)c2)CC(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CCC1O.CCOCC.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CC1(c2ccc(Cl)c(C(F)(F)F)c2)CC(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CCC1=O",
        "output": "87"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](F)[C@H]1C(=O)OCc1ccccc1.CO.[Pd]>>CC(C)(C)OC(=O)N1CC[C@@H](F)[C@H]1C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(NCC1OC1c1ccccc1)C(F)(F)F.[Cl-].[K+].[Na+].[OH-]>>NCC1OC1c1ccccc1",
        "output": "805"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.COC(=O)[C@H](N)Cc1ccccc1.O=C(O)CCc1ccccc1>>COC(=O)[C@@H](Cc1ccccc1)NC(=O)CCc1ccccc1",
        "output": "129"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1ccccc1.CCC(=O)Cl.CCC(=O)c1ccc2cc(OC)ccc2c1.CCC(=O)c1cccc(O)c1.COC(OC)OC.COc1ccc2cc(C(C)C(=O)c3ccccc3)ccc2c1.COc1ccc2ccccc2c1.ClCCl.O=C([O-])[O-].[Al+3].[Cl-].[Cl-].[Cl-].[K+].[K+]>>CCC(=O)c1cccc(Oc2ccccc2)c1",
        "output": "238"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CN(C)C=O.Cl.NC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)O.N[C@@H](Cc1ccccc1)[C@H](O)C(=O)O>>NC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)C(=O)O",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O.CC(C)(C)OC(=O)Nc1cccc(N)c1.O=Cc1ccccc1.[BH4-].[Na+]>>CC(C)(C)OC(=O)Nc1cccc(NCc2ccccc2)c1",
        "output": "359"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.COC(=O)C(C)n1ccc2cc(OCc3ccccc3)ccc21.O=C[O-].[NH4+].[OH-].[OH-].[Pd+2]>>COC(=O)C(C)n1ccc2cc(O)ccc21",
        "output": "23"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1ccc(O)cc1C.CC(C)=O.CI.O=C([O-])[O-].[K+].[K+]>>COc1ccc(C(C)=O)c(C)c1",
        "output": "62"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.C[Si](C)(C)C#Cc1cc(CCCCNC(=O)OCc2ccccc2)cc(F)c1Cl.O=C([O-])[O-].[K+].[K+]>>C#Cc1cc(CCCCNC(=O)OCc2ccccc2)cc(F)c1Cl",
        "output": "337"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)c1cccc(Cn2c(C)c(C)c3cc(C(=O)N[C@@H](C)c4cccc(C5CC5)c4)ccc32)c1.CS(C)=O.[Na+].[OH-]>>Cc1c(C)n(Cc2cccc(C(=O)O)c2)c2ccc(C(=O)N[C@@H](C)c3cccc(C4CC4)c3)cc12",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CN(C)c1ccncc1.COC(=O)c1ccc(Cn2c(CCCN)nc3ccccc32)cc1.ClCCl>>COC(=O)c1ccc(Cn2c(CCCNC(C)=O)nc3ccccc32)cc1",
        "output": "339"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1cccc(N)n1.ClC(Cl)Cl.O=C1CCC(=O)N1Br>>CCc1nc(N)ccc1Br",
        "output": "518"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)N=NC(=O)OCC.COc1cc2c(Oc3ccc4[nH]ccc4c3)ncnc2cc1O.ClCCl.OCCN1CCOCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc2c(Oc3ccc4[nH]ccc4c3)ncnc2cc1OCCN1CCOCC1",
        "output": "478"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CC2(CNC2)C1.CCOC(C)=O.CN(C)C=O.Clc1ncccn1.O.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)(C)OC(=O)N1CC2(C1)CN(c1ncccn1)C2",
        "output": "36"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1=COCCC1.Cc1ccccc1.O=[N+]([O-])c1ccc(OCCO)cc1>>O=[N+]([O-])c1ccc(OCCOC2CCCCO2)cc1",
        "output": "306"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.Cc1cccc(-n2nnn(C)c2=O)c1CBr.N#Cc1cc(O)ccc1Br.O.O=C([O-])[O-].[K+].[K+]>>Cc1cccc(-n2nnn(C)c2=O)c1COc1ccc(Br)c(C#N)c1",
        "output": "127"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CCOCCc1cccc(Br)c1.COCCn1cc(B2OC(C)(C)C(C)(C)O2)cn1>>COCCn1cc(-c2cccc(CCOCCC(=O)OC(C)(C)C)c2)cn1",
        "output": "971"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1ccc(Nc2ncnc3c2CNCC3)cn1.Clc1cccnc1Cl>>CC(C)(C)c1ccc(Nc2ncnc3c2CN(c2ncccc2Cl)CC3)cn1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NCCc1ccc(C(CCCC(=O)O)c2cccnc2)cc1.O=S(=O)(Cl)c1ccc(F)cc1>>O=C(O)CCCC(c1ccc(CCNS(=O)(=O)c2ccc(F)cc2)cc1)c1cccnc1",
        "output": "43"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CO.CO.ClCCl.NCCOCCOCCN>>CC(C)(C)OC(=O)NCCOCCOCCN",
        "output": "631"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCCCCCCCCCCCCCOCC(O)CO.CN(C)C=O.c1c[nH]cn1>>CCCCCCCCCCCCCCOCC(O)CO[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCC.O=C(O)c1cc2ccc3[nH]ccc3c2[nH]1.c1ccc(CC2CCNCC2)cc1>>O=C(c1cc2ccc3[nH]ccc3c2[nH]1)N1CCC(Cc2ccccc2)CC1",
        "output": "605"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.Cn1ccnc1SCc1cccc2cc(-c3nccs3)[nH]c12.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.[Na+]>>Cn1ccnc1S(=O)Cc1cccc2cc(-c3nccs3)[nH]c12",
        "output": "595"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCNCCC.CCN(C(C)C)C(C)C.CN(C)C=O.O.O=C(NCc1cccc(C(F)(F)F)c1)c1ccnc(-c2cc(F)ccc2[N+](=O)[O-])c1>>CCCN(CCC)c1ccc([N+](=O)[O-])c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrC(Br)(Br)Br.CCOCC.ClCCl.O=S(=O)(c1ccccc1)n1ccc2c(CO)cccc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=S(=O)(c1ccccc1)n1ccc2c(CBr)cccc21",
        "output": "750"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CN(C)C=O.O=C1c2ccccc2C(=O)N1Cc1ccc(Cl)nc1Cl>>NCc1ccc(Cl)nc1Cl",
        "output": "242"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1cc(C(=O)O)cc(Cl)c1O>>COC(=O)c1cc(Cl)c(O)c(OC)c1",
        "output": "33"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=O.CN1CCc2cc(F)c(-c3cn(C4CNC4)c4nccc(NS(=O)(=O)c5ccccc5)c34)cc21.ClCCl.[BH3-]C#N.[Na+]>>CN1CC(n2cc(-c3cc4c(cc3F)CCN4C)c3c(NS(=O)(=O)c4ccccc4)ccnc32)C1",
        "output": "217"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCOc1ccc(-c2cc3ccc(O)cc3o2)cc1.CN(C)C=O.Cc1ccc(S(=O)(=O)OC[C@H](C)NC(=O)OC(C)(C)C)cc1.O.[H-].[Na+]>>CCCOc1ccc(-c2cc3ccc(OC[C@H](C)NC(=O)OC(C)(C)C)cc3o2)cc1",
        "output": "438"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(=O)(=O)Cl.Cc1ccccc1.Nc1cc(Br)cnc1N.c1ccncc1>>CS(=O)(=O)Nc1cc(Br)cnc1N",
        "output": "812"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCCC1=O.Cc1ccc(C(N)=NO)cc1NC(=O)c1cnc2ccccn12.O=C(O)C1CC(F)C1.O=C(n1ccnc1)n1ccnc1>>Cc1ccc(-c2noc(C3CC(F)C3)n2)cc1NC(=O)c1cnc2ccccn12",
        "output": "926"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.COCCl.Oc1c(Br)c(C(F)(F)F)cc2ccccc12>>COCOc1c(Br)c(C(F)(F)F)cc2ccccc12",
        "output": "375"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CC#N.C[Si](C)(C)CCOCn1cc(C(=O)O)nc1Br.O=[Ag]>>C[Si](C)(C)CCOCn1cc(C(=O)OCc2ccccc2)nc1Br",
        "output": "403"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(CN(CC(C)OS(C)(=O)=O)c1c(C(=O)NCCOC2CCCCO2)cc([N+](=O)[O-])cc1[N+](=O)[O-])OS(C)(=O)=O.Cl.O>>CC(CN(CC(C)OS(C)(=O)=O)c1c(C(=O)NCCO)cc([N+](=O)[O-])cc1[N+](=O)[O-])OS(C)(=O)=O",
        "output": "543"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Cl.O.O=C(NCC(=O)N1CCC(Oc2ccccc2OCc2ccccc2)CC1)c1cc(-c2ccccc2)[nH]n1.[Pd].c1ccc(COOc2ccccc2NC2CCNCC2)cc1>>O=C(NCC(=O)N1CCC(Oc2ccccc2O)CC1)c1cc(-c2ccccc2)[nH]n1",
        "output": "23"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](C)(C)OCC[C@@H]1OCCc2cc(N3CCCS3(=O)=O)ccc21.NC(=O)c1ccc2c(c1)CCO[C@H]2CCO>>O=S1(=O)CCCN1c1ccc2c(c1)CCO[C@H]2CCO",
        "output": "708"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)CCBr.CCOC(=O)c1c(O)c(-c2cccs2)n[nH]c1=O.CN(C)C=O.Cl.[H-].[Na+]>>CCOC(=O)c1c(O)c(-c2cccs2)nn(CCC(C)C)c1=O",
        "output": "577"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.Cl.Fc1ccccn1.NCC(F)(F)F>>FC(F)(F)CNc1ccccn1",
        "output": "810"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.N.O=S(=O)(Cl)c1ccc(CBr)cc1.O=S(=O)(Cl)c1ccccc1CBr>>NS(=O)(=O)c1ccccc1CBr",
        "output": "245"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(O)C1CC1.Cn1c(C(F)(F)F)cc(=O)n(-c2ccc(Cl)c(C(=O)O)c2)c1=O>>CC(OC(=O)c1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)ccc1Cl)C1CC1",
        "output": "33"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)C=O.Cc1ccc(N)cc1.Cc1ccc(NC(=O)NC2(CC(=O)O)C(=O)Nc3ccccc32)cc1.On1nnc2ccccc21>>Cc1ccc(NC(=O)CC2(NC(=O)Nc3ccc(C)cc3)C(=O)Nc3ccccc32)cc1",
        "output": "365"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(CN)c1ccccc1.CCN(CC)CC.CCOC(C)=O.Cl.ClCCl.O=C(Cl)c1ccc(C(F)(F)F)cc1>>CC(C)(CNC(=O)c1ccc(C(F)(F)F)cc1)c1ccccc1",
        "output": "271"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NCCCBr.CN(C)C=O.O=C(CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1)N[C@@H](Cc1ccc(O)cc1)C(=O)O.[H-].[Na+]>>CC(C)(C)OC(=O)NCCCOc1ccc(C[C@H](NC(=O)CCCCCOc2cc(-c3ccccc3)cc(-c3ccc(F)cc3)n2)C(=O)O)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCc1c(-c2nc(-c3ccc(C(O)CN4CC(C(=O)OC(C)(C)C)C4)cc3)no2)noc1-c1ccccc1.ClCCl.O=C(O)C(F)(F)F>>CCCc1c(-c2nc(-c3ccc(C(O)CN4CC(C(=O)O)C4)cc3)no2)noc1-c1ccccc1",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#Cc1c(N)ccc(C(=O)OC)c1Cl.COC(=O)c1cc(C#C[Si](C)(C)C)c(N)c(I)c1Cl>>C#Cc1cc(C(=O)OC)c(Cl)c(I)c1N",
        "output": "337"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C[C@@H](C)c1ccc(N)cc1.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccccc1Nc1nc2c(C)cc(CC(=O)O)cc2o1.F[P-](F)(F)(F)(F)F>>CCOC(=O)C[C@@H](C)c1ccc(NC(=O)Cc2cc(C)c3nc(Nc4ccccc4C)oc3c2)cc1",
        "output": "365"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN1CCC(O)C1.CN(C)C=O.O.O=C(c1ccc(F)cc1)c1c(-c2ccc(OCCN3CCCC3)cc2)sc2ccccc12.[Cl-].[H-].[Na+].[Na+]>>CCN1CCC(Oc2ccc(C(=O)c3c(-c4ccc(OCCN5CCCC5)cc4)sc4ccccc34)cc2)C1",
        "output": "485"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOP(=O)(CSc1nc2cc(-c3ccc(Cl)c(C)c3)c(Cl)cc2[nH]1)OCC.C[Si](C)(C)Br.C[Si](C)(C)N[Si](C)(C)C.ClCCl>>Cc1cc(-c2cc3nc(SCP(=O)(O)O)[nH]c3cc2Cl)ccc1Cl",
        "output": "535"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1CCCC1=O.N#C[Cu].O=C1CC(c2c[nH]c3ccc(Br)cc23)C(=O)N1>>N#Cc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1",
        "output": "531"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CSCCN1.O=CC1CCN(c2ccc(CN3CCCC3)cc2)CC1>>c1cc(N2CCC(CN3CCSCC3)CC2)ccc1CN1CCCC1",
        "output": "484"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1Nc1cccc(S(=O)(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)c1.ClCCl.O=C(O)C(F)(F)F>>Cc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1Nc1cccc(S(=O)(=O)NC2CCNCC2)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(Cl)cc1/C=C/C(=O)O.CC1CN(Cc2ccc(F)cc2)CCN1.CCN=C=NCCCN(C)C.Cl.Cl.ClCCl>>CC1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1cc(Cl)ccc1NC(=O)OC(C)(C)C",
        "output": "811"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CNCCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.Cl.ClCCCl.O=C1CCC2(CC1)OCCO2.[Na+]>>C1COCCN(C2CCC3(CC2)OCCO3)C1",
        "output": "187"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC.CN.CS(C)=O.Cc1ccc(S(=O)(=O)OC[C@H]2CCc3cccc(-c4cc(Cl)ccc4Cl)c3O2)cc1>>CNC[C@H]1CCc2cccc(-c3cc(Cl)ccc3Cl)c2O1",
        "output": "853"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CNC(=O)c1ccc(-c2ccc(C(O)(c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)C(C)C)cc2)s1.Cl.c1ccncc1>>CNC(=O)c1ccc(-c2ccc(C(O)(c3c[nH]cn3)C(C)C)cc2)s1",
        "output": "838"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)N(C)C.CCc1cc(C(=O)O)n(C)n1.CN(C)C=O.Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)ccc1Cl.O=S(Cl)Cl>>CCc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2Cl)n(C)n1",
        "output": "844"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC#N.CCN(CC)CC.CN(C)C=O.Cl.NCCc1ccc(O)cc1.O.O=C(O)CCCCCNC(=O)OCc1ccccc1.On1nnc2ccccc21>>O=C(CCCCCNC(=O)OCc1ccccc1)NCCc1ccc(O)cc1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1cc(Oc2cc(Cl)ncn2)cc2sc(=O)[nH]c12.Cl.O.O=C1Nc2ncccc2C2(CCNCC2)O1>>Cc1cc(Oc2cc(N3CCC4(CC3)OC(=O)Nc3ncccc34)ncn2)cc2sc(=O)[nH]c12",
        "output": "162"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)CN1Cc2c(cc(Cl)c3[nH]ncc23)C[C@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O.Cl.O=C(O)C[C@@H]1Cc2cc(Br)c3[nH]ncc3c2CN(CC2CC2)C1=O.O=c1[nH]c2ccccc2cc1C1CCNCC1>>O=C(C[C@@H]1Cc2cc(Br)c3[nH]ncc3c2CN(CC2CC2)C1=O)N1CCC(c2cc3ccccc3[nH]c2=O)CC1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.COc1ccc(Nc2cc(-c3ccc(SC)cc3)nc(N)n2)cc1Cl.O=S(=O)([O-])O.O=S([O-])OO.[K+].[K+]>>COc1ccc(Nc2cc(-c3ccc(S(C)(=O)=O)cc3)nc(N)n2)cc1Cl",
        "output": "730"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O=C(O)CCCCc1ccccc1.O=S(=O)(O)O>>CCOC(=O)CCCCc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1cccc(N2CCNCC2)n1.O=C(NCC(F)(F)F)C1(CCCCBr)c2ccccc2-c2ccccc21>>Cc1cccc(N2CCN(CCCCC3(C(=O)NCC(F)(F)F)c4ccccc4-c4ccccc43)CC2)n1",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Nc1ccc(Cl)c(O)c1.O=P(O)(O)O.O=S(=O)(O)O.O=[N+]([O-])O>>CC(=O)Nc1ccc(Cl)c(O)c1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1ccc(O)cc1O.CC(=O)c1ccccc1.ClCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1ccc(OCc2ccccc2)cc1O",
        "output": "49"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCc1ccccc1Nc1c(C(N)=O)cnc2cc(O)c(OC)cc12.CN(C)C=O.COCCBr.O=C([O-])[O-].[Cs+].[Cs+]>>CCc1ccccc1Nc1c(C(N)=O)cnc2cc(OCCOC)c(OC)cc12",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)c1csc(C(=O)O)c1.Cc1cc(C)cc(CN)c1.Cl.ClCCl>>CCOC(=O)c1csc(C(=O)NCc2cc(C)cc(C)c2)c1",
        "output": "950"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)C=Cc1ccc(Br)c(F)c1.CO.[Na+].[OH-]>>O=C(O)C=Cc1ccc(Br)c(F)c1",
        "output": "122"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)C1CN(S(=O)(=O)c2ccc3cc(Cl)ccc3c2)CC(=O)N1N(C)C1CCN(c2ccncc2)CC1.Cl.Cl.[Na+].[OH-]>>CN(C1CCN(c2ccncc2)CC1)N1C(=O)CN(S(=O)(=O)c2ccc3cc(Cl)ccc3c2)CC1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N(CCC(=O)O)CCC1CCCCC1.CC(C)COC(=O)Cl.CN1CCOCC1.ClC(Cl)Cl.N>>CC(C)(C)OC(=O)N(CCC(N)=O)CCC1CCCCC1",
        "output": "313"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(C(=O)O)c1.CCN(C(C)C)C(C)C.CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CN.CN(C)C=O.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(NC(=O)OC(C)(C)C)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CCI.CCOC(=O)c1c(C(F)(F)F)nc(C(F)(F)F)c(C)c1O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1c(C(F)(F)F)nc(C(F)(F)F)c(C)c1OCC",
        "output": "198"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O.O.OCC1CCNCC1>>CC(C)(C)OC(=O)N1CCC(CO)CC1",
        "output": "694"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Br.C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O.Oc1ccc2c(c1)CCNC2.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCc2cc(O)ccc2C1",
        "output": "867"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](O)C1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccccc1.ClCc1ccccc1.[Br-].[I-].[K+].[Na+].[OH-]>>CC(C)(C)OC(=O)N1CC[C@@H](OCc2ccccc2)C1",
        "output": "208"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.Nc1ccn(-c2ccccc2Cl)n1.O=C1CCC(=O)N1Cl>>Nc1nn(-c2ccccc2Cl)cc1Cl",
        "output": "856"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#C[Si](C)(C)C.C1CCOC1.CCN(CC)CC.Cl[Pd]Cl.Nc1c(F)cc(C(F)(F)F)cc1I.[Cu]I.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>C[Si](C)(C)C#Cc1cc(C(F)(F)F)cc(F)c1N",
        "output": "826"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.NC1(CO)CCCCC1.O=C(O)c1cnc(C2CC2)c(OCC2CC2)n1>>O=C(NC1(CO)CCCCC1)c1cnc(C2CC2)c(OCC2CC2)n1",
        "output": "697"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(NCCO[Si](C)(C)C(C)(C)C)cc5c4)n3c2)cn1.[F-]>>Cn1cc(-c2ccc3nnc(Sc4ccc5ncc(NCCO)cc5c4)n3c2)cn1",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCc1nn(C)c2c(=O)[nH]c(-c3cc(C(=O)O)ccc3OCC)nc12.CCN=C=NCCCN(C)C.CN1CCNCC1.Cl.ClCCl.On1nnc2ccccc21>>CCCc1nn(C)c2c(=O)[nH]c(-c3cc(C(=O)N4CCN(C)CC4)ccc3OCC)nc12",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC[Sn](=O)CCCC.CCN(CC)CC.Cc1cc2ccccc2c(Cl)c1[C@@H](O)CO.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OC[C@H](O)c2c(C)cc3ccccc3c2Cl)cc1",
        "output": "197"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC(C(=O)OC)c1c(C)nc(N2CCCCC2)nc1-c1cccc2ncccc12.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc(N2CCCCC2)nc1-c1cccc2ncccc12",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)(C)CCOc1cccc(N)c1C#N.NS(=O)(=O)Cl>>CC(=O)OC(C)(C)CCOc1cccc(NS(N)(=O)=O)c1C#N",
        "output": "395"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.N[C@@H](CO)c1ccc(F)cc1.O=[N+]([O-])c1cc(F)c(F)c(F)c1Nc1cc(C2CC2)[nH]n1>>O=[N+]([O-])c1cc(F)c(N[C@@H](CO)c2ccc(F)cc2)c(F)c1Nc1cc(C2CC2)[nH]n1",
        "output": "764"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)C(O)(CC(C)(C)c1cccc2c1OCC2)C(F)(F)F.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(CC(O)(CO)C(F)(F)F)c1cccc2c1OCC2",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.Cl.NCCCN1c2ccc(Cl)cc2CCc2cc(Cl)ccc21.O=S(=O)(Cl)c1ccc(OC(F)(F)F)cc1>>O=S(=O)(NCCCN1c2ccc(Cl)cc2CCc2cc(Cl)ccc21)c1ccc(OC(F)(F)F)cc1",
        "output": "43"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)[C@H](N)CC(C)C.COc1ccc(C(=O)O)cc1Cl.Cl>>COC(=O)[C@@H](CC(C)C)NC(=O)c1ccc(OC)c(Cl)c1",
        "output": "652"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OCc1c(-c2cc(Nc3cc4n(n3)CCOC4)c(=O)n(C)c2)ccnc1N1CCn2c(cc3c2CCCC3)C1=O.[Li+].[OH-]>>Cn1cc(-c2ccnc(N3CCn4c(cc5c4CCCC5)C3=O)c2CO)cc(Nc2cc3n(n2)CCOC3)c1=O",
        "output": "348"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cc(N2CC[C@H](NC(=O)c3[nH]c(C)c(Cl)c3Cl)[C@H](OC)C2)ncc1N.CS(=O)(=O)Cl.c1ccncc1>>CCOC(=O)c1cc(N2CC[C@H](NC(=O)c3[nH]c(C)c(Cl)c3Cl)[C@H](OC)C2)ncc1NS(C)(=O)=O",
        "output": "812"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.CC(=O)[O-].CC(=O)[O-].Cc1ccccc1.Cc1ncc(C)n2nc(-c3ccn4cc(-c5cccc(Br)c5)nc4c3)nc12.O.O=P([O-])([O-])[O-].OB(O)C1CC1.[Br-].[K+].[K+].[K+].[Pd+2]>>Cc1ncc(C)n2nc(-c3ccn4cc(-c5cccc(C6CC6)c5)nc4c3)nc12",
        "output": "956"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.CNCCN.O=C([O-])[O-].O=c1cc(OCc2ccc(Cl)cn2)ccn1-c1ccc(F)nc1.[K+].[K+]>>CNCCNc1ccc(-n2ccc(OCc3ccc(Cl)cn3)cc2=O)cn1",
        "output": "810"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(=O)c1csc(N)n1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(Nc1ccc(C(CC2CCCC2)C(=O)O)cc1)c1cccnc1>>CCOC(=O)c1csc(NC(=O)C(CC2CCCC2)c2ccc(NC(=O)c3cccnc3)cc2)n1",
        "output": "681"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCCCNCCCCCC.CCN(CC)CC.CCOC(=O)Cl.O=C(O)c1nc2ccccc2n(Cc2ccccc2)c1=O>>CCCCCCN(CCCCCC)C(=O)c1nc2ccccc2n(Cc2ccccc2)c1=O",
        "output": "729"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)OCC[Si]([Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>C[Si](C)(C)[Si](CCO)([Si](C)(C)C)[Si](C)(C)C",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COc1cccc2[nH]c(=O)oc(=O)c12.ClCCl.O=C1CCC(=O)N1Br>>COc1c(Br)ccc2[nH]c(=O)oc(=O)c12",
        "output": "4"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)CNC(=O)c1ccc(CCn2c(COc3cccc(CC)c3)c(Cl)cc(Cl)c2=O)cc1.CO.Cl.[Na+].[OH-]>>CCc1cccc(OCc2c(Cl)cc(Cl)c(=O)n2CCc2ccc(C(=O)NCC(=O)O)cc2)c1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(OC)c(CN2Cc3nc4c(Br)cccc4c(N)c3C2=O)c1.COc1ccncc1B(O)O.OBO>>COc1ccc(OC)c(CN2Cc3nc4c(-c5cnccc5OC)cccc4c(N)c3C2=O)c1",
        "output": "883"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COCCOCCOCC(=O)O.O=C1O[C@H](CO)CN1c1ccc2cc(-c3ccccc3C(F)(F)F)[nH]c(=O)c2c1>>COCCOCCOCC(=O)OC[C@@H]1CN(c2ccc3cc(-c4ccccc4C(F)(F)F)[nH]c(=O)c3c2)C(=O)O1",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.CCOC(=O)CCCOc1ccc(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)c(CC)c1.O.[Na+].[OH-]>>CCc1cc(OCCCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COc1ccc(CN(c2ccc(F)c(Cl)c2)c2ncnc3cc(OCCCN4CCOCC4)c([N+](=O)[O-])cc23)cc1OC.[H][H].[Ni]>>COc1ccc(CN(c2ccc(F)c(Cl)c2)c2ncnc3cc(OCCCN4CCOCC4)c(N)cc23)cc1OC",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(C)=O.Cl.O=[N+]([O-])c1cc(OCc2cccc(Br)c2)ccc1Cl.Oc1ccc(O)cc1>>O=[N+]([O-])c1cc(OCc2cccc(Br)c2)ccc1Oc1ccc(O)cc1",
        "output": "299"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(CC)CC.Cc1c(Cl)cccc1S(=O)(=O)Cl.Cl.O=C(N[C@@H]1CC[C@@H](CO)CC1)[C@H]1CCCNC1>>Cc1c(Cl)cccc1S(=O)(=O)N1CCC[C@H](C(=O)N[C@@H]2CC[C@@H](CO)CC2)C1",
        "output": "99"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.OCCC1CC1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCCC2CC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.N#CC[C@@H](O)CCl.O=C(OC1CCNCC1F)c1ccccc1.O=C([O-])O.[Na+]>>N#CC[C@@H](O)CN1CCC(OC(=O)c2ccccc2)C(F)C1",
        "output": "138"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)C(C)C(c1ccc(Cl)cc1)c1cn(C(=O)OC(C)(C)C)c2c(CSC)cccc12.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)C(C)C(c1ccc(Cl)cc1)c1c[nH]c2c(CSC)cccc12",
        "output": "848"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1nc2c(Oc3ccc(N)c(F)c3)ccnc2[nH]c1=O.O=C=Nc1cc(C(F)(F)F)ccc1F>>Cc1nc2c(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)c(F)c3)ccnc2[nH]c1=O",
        "output": "912"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCNCCC.ClCCCCOc1ccccc1/C=C/c1nc2ccccc2s1>>CCCN(CCC)CCCCOc1ccccc1/C=C/c1nc2ccccc2s1",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)c1ccccc1-c1ccc(Cn2c(-c3cscn3)nc3ccccc32)cc1.O=C(O)C(F)(F)F>>O=C(O)c1ccccc1-c1ccc(Cn2c(-c3cscn3)nc3ccccc32)cc1",
        "output": "752"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC[N+](CCC)(CCC)CCC.C[C@H](CCCCO)CCCC(C)(C)O.C[N+]1([O-])CCOCC1.ClCCl>>C[C@H](CCCC=O)CCCC(C)(C)O",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.COC(=O)c1c(-c2ccc(F)cc2)oc2ccc(O)cc12.O.[Na+].[OH-]>>O=C(O)c1c(-c2ccc(F)cc2)oc2ccc(O)cc12",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)c1ccccc1O.CCN(CC)CC.CCS(=O)(=O)Cl.Cc1ccccc1.O>>CCS(=O)(=O)Oc1ccccc1C(C)(C)C",
        "output": "149"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)Cc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.Cc1noc(-c2ccc(Br)cc2)c1CC(F)(F)CCc1ccccc1>>CCOC(=O)Cc1ccc(-c2ccc(-c3onc(C)c3CC(F)(F)CCc3ccccc3)cc2)cc1",
        "output": "933"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCOCC1.COC(=O)c1ccc(Cc2c[nH]c3ccc(N)cc23)c(OC)c1.ClCCl.O=C(Cl)OC1CCCC1>>COC(=O)c1ccc(Cc2c[nH]c3ccc(NC(=O)OC4CCCC4)cc23)c(OC)c1",
        "output": "102"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)CN.Cc1c(-c2ccc(S(C)(=O)=O)cc2)nc(S(C)(=O)=O)nc1C(F)(F)F>>Cc1c(-c2ccc(S(C)(=O)=O)cc2)nc(NCC(C)C)nc1C(F)(F)F",
        "output": "629"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrC(Br)(Br)Br.C1CCOC1.CC[Si](CC)(CC)c1[nH]c2ccc(C(F)(F)F)cc2c1CCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC[Si](CC)(CC)c1[nH]c2ccc(C(F)(F)F)cc2c1CCBr",
        "output": "378"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=C(C)[C@@H]1CC[C@]2(N)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC[C@](CF)(C(=O)OCc7ccccc7)CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CC#N.O=P([O-])([O-])[O-].O=S1(=O)CCCN(CCCl)CC1.[I-].[K+].[K+].[K+].[K+]>>C=C(C)[C@@H]1CC[C@]2(NCCN3CCCS(=O)(=O)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC[C@](CF)(C(=O)OCc7ccccc7)CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12",
        "output": "279"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.Nc1ccc(Br)cc1C(F)(F)F>>CC(=O)Nc1ccc(Br)cc1C(F)(F)F",
        "output": "6"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCc1cc(Oc2ccc(NS(=O)(=O)c3ccc(C)cc3)c(C(=O)OC)c2)ccc1NS(=O)(=O)c1ccc(C)cc1.[Li+].[OH-]>>CCCc1cc(Oc2ccc(NS(=O)(=O)c3ccc(C)cc3)c(C(=O)O)c2)ccc1NS(=O)(=O)c1ccc(C)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCCO.Cc1ccccc1.O.O=C(O)C(CO)c1ccccc1.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.[Al+3].[Al+3].[O-2].[O-2].[O-2]>>CCCCCCCCOC(=O)C(CO)c1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)c1ccc(C(=O)O)cc1.CN(C)C=O.ClCCl.O=S(Cl)Cl>>CC(C)c1ccc(C(=O)Cl)cc1",
        "output": "3"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=CC1CN(Cc2ccccc2)CC1c1ccsc1.OC1(CCCc2ccccc2)CCNCC1>>OC1(CCCc2ccccc2)CCN(CC2CN(Cc3ccccc3)CC2c2ccsc2)CC1",
        "output": "484"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CCN(CC)CC.COc1cccc(C2(CNC(=O)Nc3c(C(C)C)cccc3C(C)C)CCNCC2)c1.Cl.O>>COc1cccc(C2(CNC(=O)Nc3c(C(C)C)cccc3C(C)C)CCN(C(C)=O)CC2)c1",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCBr.CCCCOc1ccc2cc(C=CC(=O)OC)ccc2c1>>CCCCOc1ccc2cc(C=CC(=O)O)ccc2c1",
        "output": "58"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOP(=O)(OCC)On1nnc2ccccc2c1=O.COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(-c2ccncc2)cc1)C[C@H](O)[C@@H](N)Cc1ccccc1)C(C)(C)C.COC(=O)N[C@H](C(=O)O)C(C)(C)C>>COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(-c2ccncc2)cc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COc1ccc(C=O)cc1.NCc1ccncc1.[BH3-]C#N.[Na+]>>COc1ccc(CNCc2ccncc2)cc1",
        "output": "468"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCNc1nc(-c2cc(C)cc(OC)c2)c(-c2ccnc(Cl)n2)s1.Nc1ccc(N2CCOCC2)c(F)c1.OCC(F)(F)F>>CCNc1nc(-c2cc(C)cc(OC)c2)c(-c2ccnc(Nc3ccc(N4CCOCC4)c(F)c3)n2)s1",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cc1c(Cl)nn2ccnc2c1Nc1cccc(O)c1.N[C@H]1CC[C@H](N)CC1.O>>Cc1c(N[C@@H]2CC[C@@H](N)CC2)nn2ccnc2c1Nc1cccc(O)c1",
        "output": "241"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)C1.CCN(CC)CC.CS(C)=O.O.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)N1CCC(=O)C1",
        "output": "650"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(C)=O.N#Cc1cccc(CBr)c1.O=C([O-])[O-].O=C1Nc2ccccc2C12COc1cc3c(cc12)CCO3.[Cs+].[Cs+]>>N#Cc1cccc(CN2C(=O)C3(COc4cc5c(cc43)CCO5)c3ccccc32)c1",
        "output": "688"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.CSc1nccc(-c2c(-c3ccc(F)cc3)nc3c(C)nccn23)n1.ClCCl.O.O=S([O-])OO.[K+]>>Cc1nccn2c(-c3ccnc(S(C)(=O)=O)n3)c(-c3ccc(F)cc3)nc12",
        "output": "840"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cc([N+](=O)[O-])ccc1OCCCCN.COc1ccc(OCC2CO2)cc1>>COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cc([N+](=O)[O-])ccc1OCCCCNCC(O)COc1ccc(OC)cc1",
        "output": "16"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc(C(F)(F)F)cc1CC1CCCCC1.ClB(Cl)Cl.ClCCl.[I-]>>Oc1ccc(C(F)(F)F)cc1CC1CCCCC1",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc(I)cc1.C1COCCO1.CC(C)(C)OC(=O)NCC1CCNCC1.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)(C)OC(=O)NCC1CCN(c2ccc(Br)cc2)CC1",
        "output": "931"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(CC)c1ccc(C#N)c2nc(Cl)n(C)c12.CN1CCCC1=O.COc1cc(Cl)cc(C)c1N.O=C([O-])O.[Na+]>>CCC(CC)c1ccc(C#N)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12",
        "output": "808"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(C)=O.NC(=O)c1c(Cl)ccc(Nc2c(Cl)c(=O)c2=O)c1O.Nc1ccccc1F>>NC(=O)c1c(Cl)ccc(Nc2c(Nc3ccccc3F)c(=O)c2=O)c1O",
        "output": "510"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)C=Cc1ccc(C=O)cc1.NCc1cccnc1>>COC(=O)C=Cc1ccc(CNCc2cccnc2)cc1",
        "output": "468"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)c1c[nH]c(SC)nc1=O.ClCCl.Clc1ccc(CBr)cc1>>CCOC(=O)c1cn(Cc2ccc(Cl)cc2)c(SC)nc1=O",
        "output": "389"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)C(=O)Cl.CCN(CC)CC.ClCCl.Nc1cccc(-c2cccc(Nc3ncccc3[N+](=O)[O-])c2)c1.O=C(O)C=Cc1ccccn1>>O=C(/C=C/c1ccccn1)Nc1cccc(-c2cccc(Nc3ncccc3[N+](=O)[O-])c2)c1",
        "output": "170"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(S)cc1.Fc1ccc(I)c(Br)c1>>Cc1ccc(Sc2ccc(F)cc2Br)cc1",
        "output": "565"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(C(C)C(=O)O)cc(C(F)(F)F)c1)C(=O)C1CC1.O=C(Cl)C(=O)Cl>>CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(C(C)C(=O)Cl)cc(C(F)(F)F)c1)C(=O)C1CC1",
        "output": "56"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.C=C(c1cc(NCCC(F)(F)F)c2ncc(-c3ccc(C(=O)NC4CC4)c(C)c3)n2n1)c1cc(F)ccc1OC.ClCCl>>C=C(c1cc(NCCC(F)(F)F)c2ncc(-c3ccc(C(=O)NC4CC4)c(C)c3)n2n1)c1cc(F)ccc1O",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=Cc1csc2c(NCc3ccccc3)nc(Cl)nc12.NCCN1CCOCC1>>C=Cc1csc2c(NCc3ccccc3)nc(NCCN3CCOCC3)nc12",
        "output": "544"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cccc(C(=O)Cl)c1.O=C1C(=O)c2ccccc2C2=C1SCC1(CCNCC1)O2>>Cc1cccc(C(=O)N2CCC3(CC2)CSC2=C(O3)c3ccccc3C(=O)C2=O)c1",
        "output": "201"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)CCCCCCCn1cnc(-c2ccccc2Cl)c1-c1ccccc1Cl.[Na+].[OH-]>>O=C(O)CCCCCCCn1cnc(-c2ccccc2Cl)c1-c1ccccc1Cl",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)Oc1ccc(F)cc1F.O=S(=O)(O)O.O=[N+]([O-])O>>COC(=O)Oc1cc([N+](=O)[O-])c(F)cc1F",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)Cn1c(=O)c2cccn2c2c(C)ccnc21.O.[Li+].[OH-]>>Cc1ccnc2c1n1cccc1c(=O)n2CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Nc1cccc(Cc2nn(-c3cccc(O)c3)ccc2=O)c1.CN(C)C=O.COS(=O)(=O)OC.O.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)Nc1cccc(Cc2nn(-c3cccc(OC)c3)ccc2=O)c1",
        "output": "317"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1ccc(Nc2nc(Nc3ccc4c(c3)CC(C(=O)O)O4)ncc2F)cc1.COC(=O)c1cc2cc(Nc3ncc(F)c(Nc4ccc5c(c4)OCCO5)n3)ccc2o1.[Li+].[OH-]>>O=C(O)c1cc2cc(Nc3ncc(F)c(Nc4ccc5c(c4)OCCO5)n3)ccc2o1",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.C[C@H]1CCCN1.ClCCl.O=C(O)C(O)C(O)C(=O)O.O=C[C@H]1C[C@@H]1c1ccc(Br)cc1.[BH3-]C#N.[Na+].[Na+].[OH-]>>C[C@H]1CCCN1C[C@H]1C[C@@H]1c1ccc(Br)cc1",
        "output": "484"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COCOc1c(C)cc(O)cc1Cl.ClCC=C(Cl)Cl.O=C([O-])[O-].[K+].[K+]>>COCOc1c(C)cc(OCC=C(Cl)Cl)cc1Cl",
        "output": "119"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CC(C)=CC(=O)COc1cc([N+](=O)[O-])ccc1F.O.[Fe]>>CC(C)=CC(=O)COc1cc(N)ccc1F",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C[C@@H]1CCCN(C(=O)c2cc(F)c(F)cc2-c2ncccn2)[C@@H]1CN.Clc1cnc(Cl)nc1>>C[C@@H]1CCCN(C(=O)c2cc(F)c(F)cc2-c2ncccn2)[C@@H]1CNc1ncc(Cl)cn1",
        "output": "544"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)CCC(=O)O.CCN=C=NCCCN(C)C.Nc1ccc(N2CCN(C(=O)c3ccccc3C(F)(F)F)CC2)nn1.O>>CC(C)CCC(=O)Nc1ccc(N2CCN(C(=O)c3ccccc3C(F)(F)F)CC2)nn1",
        "output": "795"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)N.COC(=O)c1ccc(OCc2c(-c3ccccc3)nnn2C)nc1.C[Al](C)C>>CC(C)NC(=O)c1ccc(OCc2c(-c3ccccc3)nnn2C)nc1",
        "output": "862"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)c1ccc(C(=O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1.CO.[BH4-].[Na+]>>CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1",
        "output": "24"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1ccc(OCCCCCCOC2CCCCO2)cc1.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.OCCCCCCOc1ccc2cc(Br)ccc2c1.[Cu]I.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>OCCCCCCOc1ccc2cc(C#Cc3ccc(OCCCCCCOC4CCCCO4)cc3)ccc2c1",
        "output": "659"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.N#CCBr.OC1CCNCC1>>N#CCN1CCC(O)CC1",
        "output": "880"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(C#N)c(OC)c1.ClB(Cl)Cl>>N#Cc1ccc(O)cc1O",
        "output": "20"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.O=C(Cl)c1ccccc1.OC1CCNCC1.c1ccncc1>>O=C(c1ccccc1)N1CCC(O)CC1",
        "output": "201"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1ccc(N2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1.[Cl-].[Cl-].[Cl-].[Ti+3]>>CCc1ccc(N2CCN(Cc3ccc(N)cc3)CC2)cc1",
        "output": "507"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O.Oc1cccc(N2CCNCC2)n1>>CC(C)(C)OC(=O)N1CCN(c2cccc(O)n2)CC1",
        "output": "694"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(CCC(=O)O)cc1.ClCCl.O=C(Cl)C(=O)Cl>>Cc1ccc(CCC(=O)Cl)cc1",
        "output": "56"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CO.COc1cccc(CNS(C)(=O)=O)c1.ClCCl>>CS(=O)(=O)NCc1cccc(O)c1",
        "output": "732"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)C1CC(C(=O)OC)CN(C(=O)OC(C)(C)C)C1.O.O.[Li]O>>COC(=O)C1CC(C(=O)O)CN(C(=O)OC(C)(C)C)C1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ncc(-c2c(C)cc(C(=O)OC(C)(C)C)cc2C)cc1-c1ccc(N2CCOCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C.ClCCl.O=C(O)C(F)(F)F>>COc1ncc(-c2c(C)cc(C(=O)O)cc2C)cc1-c1ccc(N2CCOCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C",
        "output": "752"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNCC1.CCO.CCOC(=O)c1c(C)[nH]c(C=O)c1CCCN1CCN(C)CC1.O=C1Cc2c(cccc2-c2cccc(F)c2)N1>>CCOC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3cccc(-c4cccc(F)c4)c32)c1CCCN1CCN(C)CC1",
        "output": "440"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)c1ccncc1.C[C@@H](O)CCO.ClCCl>>C[C@@H](O)CCO[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(CCl)c2CC1.CN(C)C=O.Oc1ccccc1.[H-].[I-].[K+].[Na+]>>CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(COc3ccccc3)c2CC1",
        "output": "49"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CN(C)C=O.COC(=O)c1cnc(Cl)c(O)c1.O.[H-].[Na+]>>COC(=O)c1cnc(Cl)c(OCc2ccccc2)c1",
        "output": "623"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.Cc1cn([C@@]2(COCc3ccccc3)C[C@H](O)[C@@H](CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)O2)c(=O)[nH]c1=O.ClCCl.O=C(Cl)c1ccccc1>>Cc1cn([C@@]2(COCc3ccccc3)C[C@H](OC(=O)c3ccccc3)[C@@H](CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)O2)c(=O)[nH]c1=O",
        "output": "51"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O.O=[N+]([O-])c1ccc(S(=O)(=O)N2CCOCC2)cc1.[Cl-].[Fe].[NH4+]>>Nc1ccc(S(=O)(=O)N2CCOCC2)cc1",
        "output": "401"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.N#CC1CCNCC1.O.O=C(Cl)CCl.O=C([O-])[O-].[Na+].[Na+]>>N#CC1CCN(C(=O)CCl)CC1",
        "output": "125"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCC.COC(CC(F)P(=O)(O)O)c1nc[nH]n1.C[Si](C)(C)Br.ClCCl>>O=P(O)(O)C(F)CC(O)c1nc[nH]n1",
        "output": "423"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCCCC(=O)N1CCCC1CNC(=O)c1ccc(-c2ccccc2C#N)nc1NCCc1cccc(F)c1.CO.Cl>>N#Cc1ccccc1-c1ccc(C(=O)NCC2CCCN2C(=O)CCCN)c(NCCc2cccc(F)c2)n1",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.C[C@@](CCn1cc(C2CCCCC2)cn1)(C(=O)[O-])S(C)(=O)=O.O.[Li+].[OH-]>>C[C@@](CCn1cc(C2CCCCC2)cn1)(C(=O)O)S(C)(=O)=O",
        "output": "151"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(CO)c2cc(C(F)(F)C(F)(F)F)nn12.ClC(Cl)Cl.[Mn+4].[O-2].[O-2]>>COc1ccc(C=O)c2cc(C(F)(F)C(F)(F)F)nn12",
        "output": "520"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCBr.Cl.O=C([O-])[O-].O=C1CCCCC1.Oc1ccc(Br)cc1F.[K+].[K+]>>CCCCCCOc1ccc(Br)cc1F",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(-n2c(C)nnc2CN)cc1.ClCCl.O=C=Nc1cccc(Br)c1>>Cc1ccc(-n2c(C)nnc2CNC(=O)Nc2cccc(Br)c2)cc1",
        "output": "35"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrP(Br)Br.CCOCC.COc1cc(CO)ccc1Br.O>>COc1cc(CBr)ccc1Br",
        "output": "300"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCCCCN.Cl.O=[N+]([O-])c1cnc2ccccc2c1Cl>>CC(C)(C)OC(=O)NCCCCNc1c([N+](=O)[O-])cnc2ccccc12",
        "output": "78"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COCCO.Cc1cc(Br)ncc1Br.[H-].[Na+]>>COCCOc1cc(C)c(Br)cn1",
        "output": "551"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)c1sc2ccccc2c1C(F)(F)F.O.O.[Li+].[OH-]>>O=C(O)c1sc2ccccc2c1C(F)(F)F",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnccc1Br.COc1ccccc1B(O)O>>COc1ccccc1-c1ccncc1N(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "872"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1ccc(C(=O)c2cccc(C)c2)cc1.ClCCl.ClCCl>>Cc1cccc(C(=O)c2ccc(O)cc2)c1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C1CCc2cccc(F)c2N1.O=S(=O)(O)O.O=[N+]([O-])O>>O=C1CCc2cc([N+](=O)[O-])cc(F)c2N1",
        "output": "21"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1c(N2CC(C)(C)CC2=O)nc2cc(F)cc(F)c2c1Cl.Cc1ccccc1.Nc1cc(N2CCOCC2)ncc1-c1ccc(OC(F)F)c(F)c1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1c(N2CC(C)(C)CC2=O)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)ncc1-c1ccc(OC(F)F)c(F)c1",
        "output": "115"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COc1cnc([N+](=O)[O-])c(OCc2c(F)cccc2F)c1.Cl.[Fe]>>COc1cnc(N)c(OCc2c(F)cccc2F)c1",
        "output": "457"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O.FC(F)(F)c1ccc2c(c1)CCNC2>>CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCc2cc(C(F)(F)F)ccc2C1",
        "output": "794"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCC(OC2CCCCO2)OC1.CCCCCC.CN(C)C=O.Cc1[nH]c(=O)c(C#N)cc1-c1ccc(O)cc1.O.OCCCBr.[H-].[Na+]>>Cc1[nH]c(=O)c(C#N)cc1-c1ccc(OCCCO)cc1",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(N)CNS(C)(=O)=O.CCN(CC)CC.Clc1ncc(Cl)c(Cl)n1>>CC(CNS(C)(=O)=O)Nc1nc(Cl)ncc1Cl",
        "output": "110"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1CCNCC1.Cc1ccc2cc(Cl)[nH]c(=O)c2c1>>Cc1ccc2cc(N3CCN(C)CC3)[nH]c(=O)c2c1",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCC.Cc1cccc(C)c1N.O=C(Cl)CCl>>Cc1cccc(C)c1NC(=O)CCl",
        "output": "9"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O.O=C(CCSC(=S)Nc1ccc(Cl)cn1)c1ccccc1.[BH4-].[K+]>>OC(CCSC(=S)Nc1ccc(Cl)cn1)c1ccccc1",
        "output": "24"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)COc1c(C(C)C)cccc1C(C)C1CC1.[BH4-].[Na+]>>CC(C)c1cccc(C(C)C2CC2)c1OCCO",
        "output": "225"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(Nc1ccc(Br)c(Br)c1)C(F)(F)F.O=S(=O)(O)O.O=[N+]([O-])O>>O=C(Nc1ccc(Br)c(Br)c1[N+](=O)[O-])C(F)(F)F",
        "output": "21"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.O.O=C1Cc2ccccc2N1>>CC(=O)c1ccc2c(c1)CC(=O)N2",
        "output": "31"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCCC(C)C(=O)O.O=S(Cl)Cl>>CCCCCCCCC(C)C(=O)Cl",
        "output": "53"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.O=C(O)c1ccc(Br)cc1I.O=S(Cl)Cl>>CCOC(=O)c1ccc(Br)cc1I",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CCCN(c2nn3cc(C(=O)O)[nH]c(=O)c3c2Cc2ccccc2Cl)C1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CO.Cl.O.O=C([O-])O.On1nnc2ccccc21.[Na+]>>COC(=O)c1cn2nc(N3CCC[C@@H](NC(=O)OC(C)(C)C)C3)c(Cc3ccccc3Cl)c2c(=O)[nH]1",
        "output": "195"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CCCCCBr.CS(C)=O.Cn1ccc(=O)[nH]c1=O.O.[H-].[Na+]>>C=CCCCCn1c(=O)ccn(C)c1=O",
        "output": "327"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)OCc1ccccc1.Cl.[Na+].[OH-]>>C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CNCC1CCN(C(=O)OC(C)(C)C)CC1.Clc1ccc(Cl)nn1>>CN(CC1CCN(C(=O)OC(C)(C)C)CC1)c1ccc(Cl)nn1",
        "output": "406"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.NCc1nc(Cl)cc(N2CCOCC2)n1.O=Cc1cccnc1.[Na+]>>Clc1cc(N2CCOCC2)nc(CNCc2cccnc2)n1",
        "output": "441"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1ccc(Br)cc1OC.Cl.[Na+].[OH-]>>COc1cc(Br)ccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(CN(Cc1cccc2cccnc12)C(=O)[C@@H](N)Cc1ccc(OC(C)(C)C)cc1)OCC.O=C(NCc1ccccc1)NCC1(C(=O)O)CC1>>CCOC(CN(Cc1cccc2cccnc12)C(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)C1(CNC(=O)NCc2ccccc2)CC1)OCC",
        "output": "133"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CCOC(C)=O.CN(C)c1ccncc1.ClCCl.Oc1ccc2cc(Br)ccc2c1>>CC(C)(C)[Si](C)(C)Oc1ccc2cc(Br)ccc2c1",
        "output": "746"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COc1nc(C(F)(F)F)ccc1C#N.[Pd]>>COc1nc(C(F)(F)F)ccc1CN",
        "output": "560"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(C(=O)O)ccc1[N+](=O)[O-].N[C@H](CO)Cc1ccccc1>>Cc1cc(C(=O)N[C@H](CO)Cc2ccccc2)ccc1[N+](=O)[O-]",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.ClCCl.Nc1cccc(C(F)(F)F)c1.O=C(O)Cc1ccc(Br)cc1.O=C(n1ccnc1)n1ccnc1>>O=C(Cc1ccc(Br)cc1)Nc1cccc(C(F)(F)F)c1",
        "output": "365"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cl.ClCCl.O=[N+]([O-])c1ccc(-c2cnc(C3CCNCC3)s2)cc1>>CS(=O)(=O)N1CCC(c2ncc(-c3ccc([N+](=O)[O-])cc3)s2)CC1",
        "output": "584"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.c1ccc(-c2ccccn2)nc1>>[O-][n+]1ccccc1-c1ccccn1",
        "output": "262"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(COC2CC2)CC1.ClCCl.O=C(O)C(F)(F)F>>C1CC(COC2CC2)CCN1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCC1(S(=O)(=O)Cl)CC1.Cc1cc(F)c(F)c(Nc2ccc(I)cc2F)c1N>>C=CCC1(S(=O)(=O)Nc2c(C)cc(F)c(F)c2Nc2ccc(I)cc2F)CC1",
        "output": "194"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1ccc(C(=O)O)cc1OC.O.O=C1CCC(=O)N1.O=C1CCc2cc(C(=O)N3CCNCC3)ccc2N1>>COc1ccc(C(=O)N2CCN(C(=O)c3ccc4c(c3)CCC(=O)N4)CC2)cc1OC",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COC(=O)Cc1cnc(Cc2ccc(N)cc2)nc1N(C)C.F[P-](F)(F)(F)(F)F.O.O=C(O)c1ccc2ccccc2c1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>COC(=O)Cc1cnc(Cc2ccc(NC(=O)c3ccc4ccccc4c3)cc2)nc1N(C)C",
        "output": "50"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1ccc(-n2nc(-c3ccccc3)c3cccnc32)cc1.O=C(O)C(F)(F)F.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Nc1ccc(-n2nc(-c3ccccc3)c3cccnc32)cc1)C(F)(F)F",
        "output": "106"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)OCC(=O)N[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1.CO.O.O=C([O-])[O-].[K+].[K+]>>O=C(CO)N[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1",
        "output": "687"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)N1CCC(NS(=O)(=O)c2cccc3c(CN4C(=O)c5ccccc5C4=O)cccc23)CC1.CO.NN>>CCOC(=O)N1CCC(NS(=O)(=O)c2cccc3c(CN)cccc23)CC1",
        "output": "418"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.C[C@@H]1CN(CC(C(=O)OCc2ccccc2)c2ccccc2)CC[C@@H]1N(C(=O)c1ccco1)c1cccc(NC(=O)OC(C)(C)C)c1.Cl.O=C([O-])[O-].[Na+].[Na+]>>C[C@@H]1CN(CC(C(=O)OCc2ccccc2)c2ccccc2)CC[C@@H]1N(C(=O)c1ccco1)c1cccc(N)c1",
        "output": "782"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.CC1CCC(O)C(C(C)(C)C)C1>>CC(=O)OC1CCC(C)CC1C(C)(C)C",
        "output": "254"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNCC1.CCO.Cc1c(C=O)[nH]c2c1C(=O)N(C[C@@H](O)CN1CCOCC1)CCC2.O=C1Cc2c(Br)cccc2N1>>Cc1c(/C=C2\\C(=O)Nc3cccc(Br)c32)[nH]c2c1C(=O)N(C[C@@H](O)CN1CCOCC1)CCC2",
        "output": "911"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.Cc1cc(Br)cc(C(=O)O)c1N.O.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)c1cc(Br)cc(C)c1N",
        "output": "415"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CC(N2CCOCC2)CN1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)c1nc2c(C(F)(F)F)cc(-c3ccoc3)cn2c1Cl>>O=C(c1nc2c(C(F)(F)F)cc(-c3ccoc3)cn2c1Cl)N1CCC(N2CCOCC2)C1",
        "output": "729"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[O-].CCCCCCCCCCCCCCCC(=O)O.Cc1cc(O)ccc1O.ClCCl.FB(F)F.O.[Na+]>>CCCCCCCCCCCCCCCC(=O)c1cc(O)c(C)cc1O",
        "output": "435"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1c(F)cccc1CC(=O)O.Cl.Cl.Cn1nc(-c2ccc3c(c2)CCN3)c2c(N)ncnc21.F[P-](F)(F)(F)(F)F.O>>Cc1c(F)cccc1CC(=O)N1CCc2cc(-c3nn(C)c4ncnc(N)c34)ccc21",
        "output": "315"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCc1nc(CC)c(Oc2ccc(OC)c(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1nc(CC)c(Oc2ccc(OC)c(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)OB(c2cc([N+](=O)[O-])ccc2F)OC1(C)C.N#Cc1cc(Cl)ccc1Br>>N#Cc1cc(Cl)ccc1-c1cc([N+](=O)[O-])ccc1F",
        "output": "933"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)C[C@@H]1N[C@@H](C(=O)O)[C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COC(=O)Cc1ccc(N)cc1.ClCCl.F[P-](F)(F)(F)(F)F>>COC(=O)Cc1ccc(NC(=O)[C@@H]2N[C@@H](CC(C)(C)C)[C@](C#N)(c3ccc(Cl)cc3F)[C@H]2c2cccc(Cl)c2F)cc1",
        "output": "563"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccccc1.O=[N+]([O-])c1c(Oc2ccccc2)nc2c(c1NCCOCCCc1cccnc1)CCCC2.[H][H].[Pt]>>Nc1c(Oc2ccccc2)nc2c(c1NCCOCCCc1cccnc1)CCCC2",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccccc1.CN(C)C=O.COC(=O)c1c[nH]c2ccccc12.O.[H-].[Na+]>>COC(=O)c1cn(Cc2ccccc2)c2ccccc12",
        "output": "528"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.C[C@H](N)Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1cc[nH]n1>>C[C@@H](Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1)NC(=O)c1cc[nH]n1",
        "output": "816"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO[Si](CCCN)(OCC)OCC.O=C1OC(=O)c2cc(C#Cc3ccccc3)ccc21>>CCO[Si](CCCN1C(=O)c2ccc(C#Cc3ccccc3)cc2C1=O)(OCC)OCC",
        "output": "341"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.CCN(C(C)C)C(C)C.ClCCl.O=C(NC(Cc1ccc(OC(F)(F)F)cc1)C(=O)NCCO)c1ccc(OCCC2CC2)cc1>>CC(=O)OCCNC(=O)C(Cc1ccc(OC(F)(F)F)cc1)NC(=O)c1ccc(OCCC2CC2)cc1",
        "output": "254"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c2c(CC(=O)O)coc12.O=[N+]([O-])c1ccccc1CO>>COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c2c(CC(=O)OCc3ccccc3[N+](=O)[O-])coc12",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(OCC3(C)Cn4cc([N+](=O)[O-])nc4O3)cc2)CC1.O=C(O)C(F)(F)F>>CC1(COc2ccc(N3CCNCC3)cc2)Cn2cc([N+](=O)[O-])nc2O1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)O.CC(C)(C)OC(=O)c1cccc(Nc2cc(Cl)nc3ccnn23)c1.Cl.Nc1cccc(Cl)c1.O.[Na+].[OH-]>>CC(C)(C)OC(=O)c1cccc(Nc2cc(Nc3cccc(Cl)c3)nc3ccnn23)c1",
        "output": "161"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.O=[N+]([O-])O.c1ccc2c(c1)CCO2>>O=[N+]([O-])c1ccc2c(c1)CCO2",
        "output": "21"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(N2CCNCC2)c(OC)c1.O=C(NCC(F)(F)F)C1(CCCCBr)c2ccccc2-c2ccccc21>>COc1ccc(N2CCN(CCCCC3(C(=O)NCC(F)(F)F)c4ccccc4-c4ccccc43)CC2)c(OC)c1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cn(CC)c2nc(N3CCCC3)ncc2c1=O.CCn1cc(C(=O)O)c(=O)c2ncc(N3CCCC3)nc21.O.[Na+].[OH-]>>CCn1cc(C(=O)O)c(=O)c2cnc(N3CCCC3)nc21",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc2c(c1)cc(CO)n2CCCl.ClCCl.[Mn+4].[O-2].[O-2]>>COc1ccc2c(c1)cc(C=O)n2CCCl",
        "output": "263"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.CC(C)(C)OC(=O)COc1ccc(Cl)cc1C#Cc1ccc(N)cc1.CC(C)(C)OC(=O)COc1ccc(Cl)cc1C#Cc1ccc(NC(=O)c2ccc(C(F)(F)F)cc2)cc1>>CC(=O)Nc1ccc(C#Cc2cc(Cl)ccc2OCC(=O)OC(C)(C)C)cc1",
        "output": "9"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCc1cc(Cl)nc(Cl)n1.CCN(C(C)C)C(C)C.CCO.ClCCl.N[C@H]1CCNC1>>CCCc1cc(N2CC[C@H](N)C2)nc(Cl)n1",
        "output": "162"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN.O=C1CCN2CCCC2C1>>CNC1CCN2CCCC2C1",
        "output": "236"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1c(C)nc2sc(Br)c(-c3cccc(OC)c3)c2c1N.CS(C)=O.O.O=CO.[Na+].[OH-]>>COc1cccc(-c2c(Br)sc3nc(C)c(C(=O)O)c(N)c23)c1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCCN1CCN(CC(=O)O)CC1.Cl.N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1>>CCOCCN1CCN(CC(=O)N[C@@H](COCc2ccccc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)cc2)CC1",
        "output": "133"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.CCC(O)(CC)c1ccc(Br)c(C)c1.CCCCCC.[Li]CCCC>>CCC(O)(CC)c1ccc(B(O)O)c(C)c1",
        "output": "832"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.Cl.O=C(O)c1ccc(F)nc1.c1cc(-c2nc(C3CCCNC3)no2)ccn1>>O=C(c1ccc(F)nc1)N1CCCC(c2noc(-c3ccncc3)n2)C1",
        "output": "256"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CN(C)C=O.O.O=C(CCl)Nc1ccc(Br)cc1[N+](=O)[O-].O=C([O-])[O-].[Cl-].[NH4+].[Na+].[Na+]>>Nc1cc(Br)ccc1NC(=O)CCl",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCCCCCCBr.C1CCOC1.O.OCCCCc1ccccc1.[H-].[Na+]>>BrCCCCCCOCCCCc1ccccc1",
        "output": "95"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(CO)NC(=O)c1cn(C)nc1C(F)F.CN(C)C=O.Cl.ClCc1c(Cl)cccc1Cl.[H-].[Na+]>>CC(COCc1c(Cl)cccc1Cl)NC(=O)c1cn(C)nc1C(F)F",
        "output": "208"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cl.Cn1cc(-c2nc3c(-c4ccc(C5(NC(=O)OC(C)(C)C)CC5)c(F)c4)ccnc3[nH]2)cn1>>Cn1cc(-c2nc3c(-c4ccc(C5(N)CC5)c(F)c4)ccnc3[nH]2)cn1",
        "output": "793"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(=O)/C=C/c1ccc(C(=C2CCCCC2)c2ccc(O)cc2C)cc1.Cl.[Na+].[OH-]>>Cc1cc(O)ccc1C(=C1CCCCC1)c1ccc(/C=C/C(=O)O)cc1",
        "output": "122"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O.O=Cc1ccc(O)cc1.OCCCCCCCl.[I-].[Na+].[Na+].[OH-]>>O=Cc1ccc(OCCCCCCO)cc1",
        "output": "74"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CC(O)C1.CN(C)C=O.FC(F)(F)c1ccccc1CBr.[H-].[Na+]>>CC(C)(C)OC(=O)N1CC(OCc2ccccc2C(F)(F)F)C1",
        "output": "464"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1nccc2c1ccc1nc3cccc(C(=O)O)c3nc12.C[C@@H](N)CN(C)C>>COc1nccc2c1ccc1nc3cccc(C(=O)N[C@H](C)CN(C)C)c3nc12",
        "output": "674"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCOc1ccc(-c2ncc(C(=O)[O-])cn2)cc1.Cl.[Na+].[OH-]>>CCCCOc1ccc(-c2ncc(C(=O)O)cn2)cc1",
        "output": "151"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)[O-].CC(=O)[O-].CCOC(=O)c1cn(C)c2ccc(Br)cc12.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.O.O=P([O-])([O-])[O-].OB(O)C1CC1.[K+].[K+].[K+].[Pd+2]>>CCOC(=O)c1cn(C)c2ccc(C3CC3)cc12",
        "output": "956"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)NC(C)c1ccc(Cl)c([N+](=O)[O-])c1.CCO.O.O=C([O-])O.O=S([O-])S(=O)[O-].[Na+].[Na+].[Na+]>>CC(=O)NC(C)c1ccc(Cl)c(N)c1",
        "output": "71"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1cc2c(Oc3cc4ccccc4nc3C)ccnc2cc1O.ClC[C@@H]1CO1.O.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(Oc3cc4ccccc4nc3C)ccnc2cc1OC[C@@H]1CO1",
        "output": "15"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CC(C(=O)Nc2cc(Oc3cc(F)c(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccn2)C1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>O=C(Nc1cc(Oc2cc(F)c(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)cc2F)ccn1)C1CNC1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)Cc1ccc2occc2c1.[Na+].[OH-]>>O=C(O)Cc1ccc2occc2c1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCN.N#Cc1ccc(F)c(Cl)c1>>CCCNc1ccc(C#N)cc1Cl",
        "output": "572"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.COc1ccc(SCC(=O)O)cc1OC.N[C@@H]1C(=O)N2C(C(=O)O)=C(/C=C3\\CCN(Cc4cccc(O)c4)C3=O)CS[C@H]12.O=C(O)C(F)(F)F.O=C(n1ccnc1)n1ccnc1>>COc1ccc(SCC(=O)N[C@@H]2C(=O)N3C(C(=O)O)=C(/C=C4\\CCN(Cc5cccc(O)c5)C4=O)CS[C@H]23)cc1OC",
        "output": "133"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)CC(c1ccc(OCc2ccccc2)cc1)N(C)C(=O)OC(C)(C)C.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Mg+2].[Na+].[OH-]>>CN(C(=O)OC(C)(C)C)C(CCO)c1ccc(OCc2ccccc2)cc1",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrP(Br)Br.C1CCOC1.Nc1nccc2ccc(CO)cc12>>Nc1nccc2ccc(CBr)cc12",
        "output": "300"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C(C)(C)C)C(C)(C)C)c(C(C)C)c1.CN.Cc1cc(F)c(NC(=O)NCCC2CC2)cc1-c1cc2cnc(Cl)cc2nc1C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>CNc1cc2nc(C)c(-c3cc(NC(=O)NCCC4CC4)c(F)cc3C)cc2cn1",
        "output": "110"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCc1cccc(Br)c1.CC#N.CCN(CC)CC.Cl.Clc1cccc(N2CCNCC2)c1Cl.O>>Clc1cccc(N2CCN(Cc3cccc(Br)c3)CC2)c1Cl",
        "output": "248"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cccc(C2CCN(C(=O)Cn3nc(C(F)F)cc3C(F)F)CC2)n1.O.O.[Li+].[OH-]>>O=C(O)c1cccc(C2CCN(C(=O)Cn3nc(C(F)F)cc3C(F)F)CC2)n1",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C(O)c1ccccc1.c1ccccc1>>O=C(c1ccccc1)c1ccccc1",
        "output": "275"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)Nc1nc2cc(O)ccc2[nH]1.CC(C)=O.CCN(CC)CC.O=S(=O)(Cl)c1ccc(F)cc1>>CC(C)(C)OC(=O)Nc1nc2cc(OS(=O)(=O)c3ccc(F)cc3)ccc2[nH]1",
        "output": "380"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)Cn1c(C(=O)OCc2ccccc2)cc2ccccc21.CCO.CN(C)C=O>>CC(C)(C)OC(=O)Cn1c(C(=O)O)cc2ccccc21",
        "output": "291"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.O=C1COc2cccc([N+](=O)[O-])c2N1.[Pd]>>Nc1cccc2c1NC(=O)CO2",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)CCCCCCCNC(=O)C=C1c2ccccc2-c2ccccc21.Cl.O.[Li+].[OH-]>>O=C(O)CCCCCCCNC(=O)C=C1c2ccccc2-c2ccccc21",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1cc(OCCc2cccnc2)cc(Oc2ccc(CN(Cc3ccc(C#N)cc3)c3cccc(NS(C)(=O)=O)c3C)cc2)c1.Cl.[Li+].[OH-]>>Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccc(C#N)cc1)Cc1ccc(Oc2cc(OCCc3cccnc3)cc(C(=O)O)c2)cc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.Cn1ncnc1CO.Fc1ccc(-c2nnc3cc(N4CCCC4)c(Cl)nn23)c(F)c1.[H-].[Na+]>>Cn1ncnc1COc1nn2c(-c3ccc(F)cc3F)nnc2cc1N1CCCC1",
        "output": "407"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCc1ccc2sccc2c1.CN(C)C=O.O.[C-]#N.[Na+]>>N#CCc1ccc2sccc2c1",
        "output": "39"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#CCOc1cc(Cl)ncn1.CN(C)C=O.O=C([O-])[O-].Oc1c(Cl)cc(F)cc1Cl.[Cl-].[K+].[K+].[NH4+]>>CC#CCOc1cc(Oc2c(Cl)cc(F)cc2Cl)ncn1",
        "output": "668"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN=C=O.COCC(=O)Nc1c(C)cc(O)cc1C.N#CCc1ccccc1>>CNC(=O)Oc1cc(C)c(NC(=O)COC)c(C)c1",
        "output": "104"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "N=C(NN)c1ccccn1.O=Cc1c(Cl)cccc1Cl>>Clc1cccc(Cl)c1-c1nc(-c2ccccn2)n[nH]1",
        "output": "994"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)CCNC(=O)c1ccc(-c2cc(Cl)cc(CNc3ccc(-c4ccc(F)cc4)cc3)c2)cn1.Cl.[Na+].[OH-]>>O=C(O)CCNC(=O)c1ccc(-c2cc(Cl)cc(CNc3ccc(-c4ccc(F)cc4)cc3)c2)cn1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(Br)cc1NC(=O)OC(C)(C)C.OB(O)c1ccccc1OC(F)(F)F>>CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2OC(F)(F)F)cc1NC(=O)OC(C)(C)C",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.Cl[Pd]Cl.N#Cc1cc(Br)ccc1NC(=O)C1CC1.O.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc(NC(=O)C3CC3)c(C#N)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1cccc(F)c1.CCO.O.O=Cc1cccc(F)c1.[K+].[OH-]>>O=C(/C=C/c1cccc(F)c1)c1cccc(F)c1",
        "output": "656"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "FC(F)(F)c1nnc2ccc(N3CCNCC3)nn12.O=Cc1cc2ccccc2[nH]1>>FC(F)(F)c1nnc2ccc(N3CCN(Cc4cc5ccccc5[nH]4)CC3)nn12",
        "output": "829"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN=C=NCCCN(C)C.Cl.ClCCl.O=C(NC1CCNCC1)c1ccc(F)cc1.O=C(O)C1CC1.On1nnc2ccccc21>>O=C(NC1CCN(C(=O)C2CC2)CC1)c1ccc(F)cc1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCO.CCN(CC)CC.COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.[Na+]>>CCCCOC(=O)Nc1cc(C)c(Oc2ccnc3cc(OC)c(OC)cc23)cc1C",
        "output": "960"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(=O)CCNC.CN(C)C=O.Cc1c(C(Nc2ccc(C(=O)O)cc2)C2CCCCC2)sc2ncccc12.Cl.O.On1nnc2ccccc21.[Cl-].[NH4+]>>CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2sc3ncccc3c2C)C2CCCCC2)cc1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1[N+](=O)[O-].Cl.[Fe].[Na+].[OH-]>>CCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COc1ccc(S(=O)(=O)Cl)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1.N#Cc1cccc2[nH]ccc12.[H-].[Na+]>>COc1ccc(S(=O)(=O)n2ccc3c(C#N)cccc32)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1",
        "output": "648"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCC#Cc1ccc(C(=O)OCC)cc1.CO.O.[Na+].[OH-]>>CCCC#Cc1ccc(C(=O)O)cc1",
        "output": "5"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)N1C(=O)Cc2cc([N+](=O)[O-])cc(F)c21.CCO.ClCCl.O.[Cl-].[Fe].[NH4+]>>CC(C)N1C(=O)Cc2cc(N)cc(F)c21",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(C)=O.C[C@@H]1CN(CCCO)C(=O)CCN1C(=O)OC(C)(C)C.ClCCl.O=C(Cl)C(=O)Cl.O=P([O-])(O)O.[K+]>>C[C@@H]1CN(CCC=O)C(=O)CCN1C(=O)OC(C)(C)C",
        "output": "142"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cc1ccc(Sc2ccc(CN)cc2)cc1.Nc1ncccc1C(=O)O.O=C([O-])O.On1nnc2ccccc21.[Na+]>>Cc1ccc(Sc2ccc(CNC(=O)c3cccnc3N)cc2)cc1",
        "output": "790"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(C)(C)CC=O.CCN(CC)CC.CO.Cc1cc(C(=O)N2CCc3nc(C)n(Cc4ccccc4)c3-c3ccccc32)ccc1OCCCN1CCNCC1.Cl.Cl.[BH3-]C#N.[Na+]>>Cc1cc(C(=O)N2CCc3nc(C)n(Cc4ccccc4)c3-c3ccccc32)ccc1OCCCN1CCN(CCC(C)(C)C)CC1",
        "output": "484"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.COc1ccc(CNC(=O)c2cc(C#N)ccc2N[C@@H](C)CO)cc1OC.CS(=O)(=O)Cl.c1ccncc1>>COc1ccc(CNC(=O)c2cc(C#N)ccc2N[C@@H](C)COS(C)(=O)=O)cc1OC",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCC2=NCCCN2CC1.CCOC(C)=O.Nc1cc(N2CCCc3ccccc3C2)nc2ccccc12.O=C(Cl)CCl>>O=C(CCl)Nc1cc(N2CCCc3ccccc3C2)nc2ccccc12",
        "output": "9"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Fc1ccc(OCCCCl)cc1.O.O=C([O-])[O-].OC1(c2ccc(Cl)cc2)CCNCC1.[Na+].[Na+]>>OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1",
        "output": "138"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cl[Pd]Cl.N#Cc1ccc(-c2cnc3ccc(Cl)nn23)cc1.O.O=C(O)c1ccc(B(O)O)cc1F.O=C([O-])[O-].[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)O)c(F)c4)nn23)cc1",
        "output": "866"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)[O-].C[Si](C)(C)CCOCCl.O=S(=O)(c1ccc(F)cc1)c1n[nH]c2cc(Br)ccc12.[Na+]>>C[Si](C)(C)CCOCn1nc(S(=O)(=O)c2ccc(F)cc2)c2ccc(Br)cc21",
        "output": "910"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)c1cnn(C)c1.[Na+].[OH-]>>Cn1cc(C(=O)O)cn1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Oc1ccc(C=C2Oc3ccccc3NC2=O)cc1.Cl.[Na+].[OH-]>>O=C1Nc2ccccc2OC1=Cc1ccc(O)cc1",
        "output": "22"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.NCCNC1=NS(=O)(=O)c2cc(Cl)ccc2N1.O.O.O=CO>>O=CNCCNC1=NS(=O)(=O)c2cc(Cl)ccc2N1",
        "output": "370"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1nc(-c2ccc(Cl)c(OCC(F)F)c2F)cc(N)c1Cl.Cl.[Na+].[OH-]>>Nc1cc(-c2ccc(Cl)c(OCC(F)F)c2F)nc(C(=O)O)c1Cl",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(C)=O.OC1(c2ccc(C(F)(F)F)cc2)CCN(c2ccc(OCc3ccccc3)cc2)CC1.[OH-].[OH-].[Pd+2]>>Oc1ccc(N2CCC(O)(c3ccc(C(F)(F)F)cc3)CC2)cc1",
        "output": "698"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NC1CC1.Nc1nc(Cl)cc(-c2cccc(Cl)c2Cl)n1>>Nc1nc(NC2CC2)cc(-c2cccc(Cl)c2Cl)n1",
        "output": "110"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1CCCC1=O.Fc1ccc(CBr)cc1Cl.O=C1CCCCN1.[H-].[Na+]>>O=C1CCCCN1Cc1ccc(F)c(Cl)c1",
        "output": "774"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)/C=C/c1ccc(C(=C2CCCCC2)c2ccc(O)cc2)c(F)c1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)/C=C/c1ccc(C(=C2CCCCC2)c2ccc(O)cc2)c(F)c1",
        "output": "158"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCN)CC1.O=Cc1ccncc1>>COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCNCc2ccncc2)CC1",
        "output": "468"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)CN1CCN(c2ccc(N(CCO[Si](C)(C)C(C)(C)C)C(=O)c3c(Cl)ncnc3Cl)cc2C)C1=O.Cl.O>>CCOC(=O)CN1CCN(c2ccc(N(CCO)C(=O)c3c(Cl)ncnc3Cl)cc2C)C1=O",
        "output": "708"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCN(CC)CCn1nc2c3c(c(N)ccc31)Sc1ccccc1-2.ClC(Cl)Cl.O=C(Cl)CCl>>CCN(CC)CCn1nc2c3c(c(NC(=O)CCl)ccc31)Sc1ccccc1-2",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)c1ccc(N)cc1.CCCCCCCCCCCCCCCCBr.CN(C)P(=O)(N(C)C)N(C)C.O=C([O-])[O-].[K+].[K+]>>CCCCCCCCCCCCCCCCNc1ccc(C(C)=O)cc1",
        "output": "273"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Cc1c(C(=O)N2CCOCC2)c[nH]c1C=O.O=C(O)Cc1cccc(-c2cccc3c2CC(=O)N3)c1>>Cc1c(C(=O)N2CCOCC2)c[nH]c1/C=C1\\C(=O)Nc2cccc(-c3cccc(CC(=O)O)c3)c21",
        "output": "911"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)c1cn2c(=O)[nH]nc2c(NC(C)C)n1.Cl.[K+].[OH-]>>CC(C)Nc1nc(C(=O)O)cn2c(=O)[nH]nc12",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CSC.O=C(O)c1ccc(Br)cc1O>>OCc1ccc(Br)cc1O",
        "output": "72"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC#N.CC(C)(C)Cc1cc(C(=O)O)no1.CC(C)(C)N.CCN=C=NCCCN(C)C.On1nnc2ccccc21>>CC(C)(C)Cc1cc(C(=O)NC(C)(C)C)no1",
        "output": "696"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "B1C2CCCC1CCC2.C1CCOC1.C1CCOC1.C=CCc1cnc2c(c1[Si](C)(C)C)CCO2.CN(C)CCN(C)C.OO.[Na+].[OH-]>>C[Si](C)(C)c1c(CCCO)cnc2c1CCO2",
        "output": "465"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(C)=O.CCOC(=O)C1(CCCCCl)CCC1.CCOCC.[I-].[Na+]>>CCOC(=O)C1(CCCCI)CCC1",
        "output": "97"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CCCO.CCNCC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Clc1cccc(Cl)c1I.I[Cu]I>>OCCC#Cc1c(Cl)cccc1Cl",
        "output": "664"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1ncc(B2OC(C)(C)C(C)(C)O2)cc1NS(=O)(=O)c1ccc(F)cc1F.Cn1c(=NC#N)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(Br)ccc3ncc21.O=C([O-])[O-].[Na+].[Na+]>>COc1ncc(-c2ccc3ncc4c(c3c2)n(-c2ccc(C(C)(C)C#N)cc2)c(=NC#N)n4C)cc1NS(=O)(=O)c1ccc(F)cc1F",
        "output": "954"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.C[C@H]1CCCN1c1ccc([N+](=O)[O-])c(C(F)(F)F)n1.[BH4-].[Na+]>>C[C@H]1CCCN1c1ccc(N)c(C(F)(F)F)n1",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)c1nc(-c2cccc(N)c2F)c(-c2ccnc(N)n2)s1.O=S(=O)(Cl)c1cccc(F)c1>>CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3cccc(F)c3)c2F)c(-c2ccnc(N)n2)s1",
        "output": "68"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CN(C)C=O.Cc1cc(F)cc(C)c1[N+](=O)[O-].O.O=C([O-])[O-].[K+].[K+]>>Cc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)cc(C)c1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COC(=O)[C@H](Cc1cccc(C#N)c1)[C@@H](C)N.COc1ccc(-c2ccc(C(=O)O)cc2)cn1.F[B-](F)(F)F>>COC(=O)[C@H](Cc1cccc(C#N)c1)[C@@H](C)NC(=O)c1ccc(-c2ccc(OC)nc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1ccc(CCc2cccc3c2NCC3)cc1.COc1cccc(S(=O)(=O)Cl)c1.Cl.c1ccncc1>>COC(=O)c1ccc(CCc2cccc3c2N(S(=O)(=O)c2cccc(OC)c2)CC3)cc1",
        "output": "791"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)Cn1c(Cc2ccccc2)ccc1-c1ccccc1.[Li+].[OH-]>>O=C(O)Cn1c(Cc2ccccc2)ccc1-c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC[C@H](N)C(=O)OCc1ccccc1.CCN=C=NCCCN(C)C.CN(C)C=O.COC1CCCC1.C[C@@H](OC(C)(C)C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O.Cl.O.O=C([O-])[O-].On1nnc2ccccc21.[Cl-].[Na+].[Na+].[Na+]>>C[C@@H](OC(C)(C)C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N[C@@H](COC(C)(C)C)C(=O)OCc1ccccc1",
        "output": "132"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COc1ccc(C)nc1[N+](=O)[O-].[C].[Pd]>>COc1ccc(C)nc1N",
        "output": "457"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CN1CCN(c2cccc3c2C[C@H](N)CO3)CC1.Cc1cncc(C(=O)O)c1.O=C(n1ccnc1)n1ccnc1>>Cc1cncc(C(=O)N[C@@H]2COc3cccc(N4CCN(C)CC4)c3C2)c1",
        "output": "674"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)C(=S)Sc1cnccc1N.CCN(CC)CC.CN(C)C=O.CSc1ncc(Br)c(C(=O)O)n1.ClCCl.O=C(Cl)C(=O)Cl>>CCN(CC)C(=S)Sc1cnccc1NC(=O)c1nc(SC)ncc1Br",
        "output": "548"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.CCCCCC(C)c1cc(O)c2c(c1)OC(C)(C)c1ccncc1-2.c1ccncc1>>CCCCCC(C)c1cc(OC(C)=O)c2c(c1)OC(C)(C)c1ccncc1-2",
        "output": "46"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)c1c(-c2ccccc2)ccnc1Oc1nc(OC)cc(OC)n1.CS(C)=O.O.[Na+].[OH-]>>COc1cc(OC)nc(Oc2nccc(-c3ccccc3)c2C(=O)O)n1",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(CO)N(C)c1cc(Br)c(C(F)(F)F)cc1[N+](=O)[O-].ClCCl.O=S(Cl)Cl.c1ccncc1>>CC(CCl)N(C)c1cc(Br)c(C(F)(F)F)cc1[N+](=O)[O-]",
        "output": "96"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.CNOC.C[Si](C)(C)C#Cc1ccc(N)c(C(=O)O)c1.Cl.F[P-](F)(F)(F)(F)F.O>>CON(C)C(=O)c1cc(C#C[Si](C)(C)C)ccc1N",
        "output": "828"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.COc1ccc(CN2Cc3c(Oc4ccc(N)cc4F)ccnc3NC2=O)cc1.O=C=Nc1cccc(Cl)c1>>COc1ccc(CN2Cc3c(Oc4ccc(NC(=O)Nc5cccc(Cl)c5)cc4F)ccnc3NC2=O)cc1",
        "output": "912"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CC(C)N.O.O=C(Cl)c1ccc([N+](=O)[O-])cc1.[Na+].[OH-]>>CC(C)NC(=O)c1ccc([N+](=O)[O-])cc1",
        "output": "271"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cc(C(C)(C)C)cc(C)c1S(=O)(=O)Cl.Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1.c1ccncc1>>Cc1cc(C(C)(C)C)cc(C)c1S(=O)(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "68"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(C)(C)c1ccc(Br)c(F)c1O.Clc1ncccn1.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)(C)c1ccc(Br)c(F)c1Oc1ncccn1",
        "output": "542"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCC.CCOC(C)=O.CN(C)C=O.CO.ClC(Cl)Cl.N#Cc1ccnc(N)c1.O=C([O-])O.O=C1CCC(=O)N1Cl.[Na+]>>N#Cc1cc(N)ncc1Cl",
        "output": "743"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.Cc1cccc(C(=O)O)c1C.Cc1ccccc1.O=C(Cl)C(=O)Cl.O=C(Cl)C(=O)Cl>>Cc1cccc(C(=O)Cl)c1C",
        "output": "448"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.N#CCOc1cc(F)c(C=O)c(F)c1.[BH4-].[Na+]>>N#CCOc1cc(F)c(CO)c(F)c1",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC=Cc1c(C(C)C)nc(C(C)C)c(C(=O)OCC)c1-c1cccc(F)c1.CCCCCC.CCOC(C)=O>>CCCC=Cc1c(C(C)C)nc(C(C)C)c(CO)c1-c1cccc(F)c1",
        "output": "383"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=C(O)[C@H](CSc1ccccc1[N+](=O)[O-])N1C(=O)c2ccccc2C1=O.[C].[Pd]>>Nc1ccccc1SC[C@@H](C(=O)O)N1C(=O)c2ccccc2C1=O",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.C1CCOC1.CO.O.O=C(O)CCc1ccc(C(F)(F)F)c(F)c1>>OCCCc1ccc(C(F)(F)F)c(F)c1",
        "output": "231"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=[N+]([O-])c1c(O)cccc1O.[H][H].[Pd]>>Nc1c(O)cccc1O",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1ccccc1OCCCNC(C)(C)C.CCO.O.O=Cc1cccc2[nH]ccc12.[Na+].[OH-]>>CC(C)(C)NCCCOc1ccccc1C(=O)C=Cc1cccc2[nH]ccc12",
        "output": "295"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCOCC.N#CCCC(c1ccccc1)c1ccccc1.O.O=C([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[K+].[K+].[Li+]>>NCCCC(c1ccccc1)c1ccccc1",
        "output": "246"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.COC(=O)CN(C)Cc1ccc([N+](=O)[O-])cc1>>COC(=O)CN(C)Cc1ccc(N)cc1",
        "output": "507"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)c1ccc2cc(C(=O)O)c(=O)oc2c1.COC1=CC(=O)N(c2cc(N)cc(N3C(=O)C=C(OC)C3=O)c2)C1=O.ClCCCl.O=P(Cl)(Cl)Cl>>CCN(CC)c1ccc2cc(C(=O)Nc3cc(N4C(=O)C=C(OC)C4=O)cc(N4C(=O)C=C(OC)C4=O)c3)c(=O)oc2c1",
        "output": "799"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.O=C(N[C@@H]1CC(=O)N(c2ccc3c(c2)CCNCC3)C1)OCc1ccccc1.O=C([O-])O.[Na+].[Na+]>>CN1CCc2ccc(N3C[C@H](NC(=O)OCc4ccccc4)CC3=O)cc2CC1",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1CC(O)(CNC(=O)c2c(Cl)ccc3nc(Cl)ccc23)CCC1(F)F.CCN(C(C)C)C(C)C.CN(C)[C@H]1CCNC1>>CC1CC(O)(CNC(=O)c2c(Cl)ccc3nc(N4CC[C@H](N(C)C)C4)ccc23)CCC1(F)F",
        "output": "220"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.Cc1c[nH]c2ccccc12.ClCCl>>Cc1cn(C(=O)OC(C)(C)C)c2ccccc12",
        "output": "748"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC(CNC(=O)CNC(=O)OCc2ccccc2)CC1.CO.[Pd]>>CC(C)(C)OC(=O)N1CCC(CNC(=O)CN)CC1",
        "output": "128"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CCO.CCOc1cc(C=O)ccc1C.O=C1NC(=O)C2(CCNCC2)N1.[BH3-]C#N.[Na+]>>CCOc1cc(CN2CCC3(CC2)NC(=O)NC3=O)ccc1C",
        "output": "567"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCOC(=O)Cl.CN[C@H]1CN(C(=O)C2CCN(C(=O)C3(C)CC3)CC2)C[C@@H]1c1ccc(Cl)cc1>>CCCCOC(=O)N(C)[C@H]1CN(C(=O)C2CCN(C(=O)C3(C)CC3)CC2)C[C@@H]1c1ccc(Cl)cc1",
        "output": "219"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C(CC1CCCC1)c1ccc([N+](=O)[O-])cc1.CO.[Na+].[OH-]>>O=C(O)C(CC1CCCC1)c1ccc([N+](=O)[O-])cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(O)CC(=O)O.O=Cc1cccc([N+](=O)[O-])c1.c1ccncc1>>O=C(O)C=Cc1cccc([N+](=O)[O-])c1",
        "output": "12"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COc1ccc(OCCCN2CCCCC2)cc1[N+](=O)[O-].[Pd]>>COc1ccc(OCCCN2CCCCC2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClC(Cl)Cl.Cn1cc(Br)c(-c2cccc(N)c2)n1.F[P-](F)(F)(F)(F)F.O.O.O=C(O)Cc1ccccc1F.On1nnc2ccccc21.[Cl-].[Na+]>>Cn1cc(Br)c(-c2cccc(NC(=O)Cc3ccccc3F)c2)n1",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CCCCBr.CCCn1nc(C(=O)NC2CCNCC2)c2ccccc21.Cl.[F-].[K+]>>CCCCN1CCC(NC(=O)c2nn(CCC)c3ccccc23)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cnc(Nc2ccccc2/C=C/c2n[nH]c3ccccc23)s1.CO.O.[Na+].[OH-]>>O=C(O)c1cnc(Nc2ccccc2/C=C/c2n[nH]c3ccccc23)s1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NCC1CCOC1.O.O=C(O)c1cc(COc2cccc(Cl)c2)on1.On1nnc2ccccc21>>O=C(NCC1CCOC1)c1cc(COc2cccc(Cl)c2)on1",
        "output": "696"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCCOc1ccc(OC)cc1-c1ccc(COc2cccc(CCC(=O)OC)c2)cc1C.CO.[Li+].[OH-]>>CCCCOc1ccc(OC)cc1-c1ccc(COc2cccc(CCC(=O)O)c2)cc1C",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)CC/C(=N\\OCc1ccc(OCc2nc(-c3ccccc3)sc2C)cc1)c1ccccc1.Cl.O.O.[Li+].[OH-]>>Cc1sc(-c2ccccc2)nc1COc1ccc(CO/N=C(\\CCC(=O)O)c2ccccc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.Cc1ccc(CO)cc1.O=C([O-])[O-].O=C1CCC(=O)O1.[Cs+].[Cs+]>>Cc1ccc(COC(=O)CCC(=O)O)cc1",
        "output": "139"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CCO.O=C1CCCc2nc(N3CCN(Cc4ccccc4)CC3)ncc21.[Pd].c1ccc2ncncc2c1>>O=C1CCCc2nc(N3CCNCC3)ncc21",
        "output": "84"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O=[N+]([O-])c1cc(OCCN2CCOCC2)cc(C(F)(F)F)c1.[Pd]>>Nc1cc(OCCN2CCOCC2)cc(C(F)(F)F)c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCc1ccccc1.CN(C)C=O.Cl.Cl.O=C([O-])[O-].O=C1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)[C@H]1O5.[K+].[K+]>>O=C1CC[C@@]2(O)[C@H]3Cc4ccc(OCc5ccccc5)c5c4[C@@]2(CCN3CC2CC2)[C@H]1O5",
        "output": "127"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCC(CC)C(=O)Cl.COC(=O)c1ccc(Cc2c[nH]c3ccc(N)cc23)c(OC)c1>>CCCCC(CC)C(=O)Nc1ccc2[nH]cc(Cc3ccc(C(=O)OC)cc3OC)c2c1",
        "output": "9"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)CCc1ccc(OCc2nc(-c3ccco3)oc2C)c(OC)c1.CO.O.[BH4-].[Na+]>>COc1cc(CCCO)ccc1OCc1nc(-c2ccco2)oc1C",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)CCC(F)(F)C(F)(F)Br>>O=C(Cl)CCC(F)(F)C(F)(F)Br",
        "output": "56"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.CC1(C)[C@@H]2CC[C@@]1(C)c1[nH]n(-c3ccccc3)c(=O)c12.CCBr.CO.O=C([O-])[O-].[K+].[K+]>>CCn1c2c(c(=O)n1-c1ccccc1)[C@H]1CC[C@]2(C)C1(C)C",
        "output": "577"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COc1cccc(CCN)c1.Clc1nc(Cl)c2ncn(C3CCCC3)c2n1>>COc1cccc(CCNc2nc(Cl)nc3c2ncn3C2CCCC2)c1",
        "output": "145"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=O)Cl.CN(C)c1ccncc1.ClCCl.Nc1ccc([N+](=O)[O-])cc1.c1ccncc1>>CCC(=O)Nc1ccc([N+](=O)[O-])cc1",
        "output": "9"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC(=O)O.CC(C)O.COC(=O)[C@@H](NC(=O)c1ccc(C#CC#CCO)cc1)C(C)(C)O.NO.O>>CC(C)(O)[C@H](NC(=O)c1ccc(C#CC#CCO)cc1)C(=O)NO",
        "output": "376"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)CC1CC1CCC(=O)Cl.CC(C)CC1CC1CCC(=O)Oc1ccc(C(=O)CNC(C)(C)C)cc1OC(=O)CCC1CC1CC(C)C.O=C(Cl)C1CCCCC1>>CC(C)CC1CC1CCC(=O)Oc1ccc(C(O)CNC(C)(C)C)cc1OC(=O)CCC1CC1CC(C)C",
        "output": "24"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.COc1ccc2c(c1)CC(=O)N2.O=C([O-])O.[Na+]>>O=C1Cc2cc(O)ccc2N1",
        "output": "402"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=C(O)c1nc(Cl)ccc1F.O=S(=O)(O)O.[Na+].[OH-]>>COC(=O)c1nc(Cl)ccc1F",
        "output": "331"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCO.CN(C)C=O.O=C(O)[C@H]1CCCNC1>>CC(C)(C)OC(=O)N1CCC[C@H](C(=O)O)C1",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.NC(=O)CCl.O=C([O-])[O-].Oc1ccc(-c2cc(-c3ccccc3)c3ccccc3n2)cc1.[K+].[K+]>>NC(=O)COc1ccc(-c2cc(-c3ccccc3)c3ccccc3n2)cc1",
        "output": "458"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCC(=O)Nc1nn(COCC[Si](C)(C)C)c2cc(Cl)c(-c3ccc(OCc4ccccc4)cc3)cc12.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.[F-]>>CCCC(=O)Nc1n[nH]c2cc(Cl)c(-c3ccc(OCc4ccccc4)cc3)cc12",
        "output": "813"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)c1cccc(C(C)(C)N)c1.CCN(CC)CC.ClCCl.O=C(Cl)Cc1ccc(Cl)cc1>>CC(=O)c1cccc(C(C)(C)NC(=O)Cc2ccc(Cl)cc2)c1",
        "output": "206"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCc1sc(C(=O)OC)cc1B1OC(C)(C)C(C)(C)O1.CO.[Na+].[OH-]>>CCc1sc(C(=O)O)cc1B1OC(C)(C)C(C)(C)O1",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1ccccc1NCc1ccncc1.NN>>NNC(=O)c1ccccc1NCc1ccncc1",
        "output": "421"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CN(C)c1ccncc1.CS(=O)(=O)c1ccc(C(CO)=C(CO)c2ccccc2)cc1.ClCCl>>CC(=O)OC/C(=C(\\CO)c1ccccc1)c1ccc(S(C)(=O)=O)cc1",
        "output": "155"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(N=[N+]=[N-])c1nc2sccn2c(=O)c1-c1ccccc1.CCOC(C)=O.CP(C)C.O>>CC(N)c1nc2sccn2c(=O)c1-c1ccccc1",
        "output": "89"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1CCCC1=O.CN1CCNCC1.O.O=C(Nc1nc(-c2ccco2)c(N2CCOCC2)s1)c1ccnc(Cl)c1>>CN1CCN(c2cc(C(=O)Nc3nc(-c4ccco4)c(N4CCOCC4)s3)ccn2)CC1",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)c1ccc2nc(-c3ccc(Br)cc3)[nH]c2c1.OB(O)c1ccc(F)cc1>>CS(=O)(=O)c1ccc2nc(-c3ccc(-c4ccc(F)cc4)cc3)[nH]c2c1",
        "output": "837"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COCCc1nc2c(N)nc3ccccc3c2n1CCOCCN1C(=O)c2ccccc2C1=O.NN.O>>COCCc1nc2c(N)nc3ccccc3c2n1CCOCCN",
        "output": "242"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)c1ccncc1.CNC.Cl.ClCCCl.ClCCl.O.O=C(O)c1ccccc1CSc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1>>CN(C)C(=O)c1ccccc1CSc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#Cc1cccc(C(=O)Cl)c1.ClCCl.Oc1ccccc1.c1ccncc1>>C#Cc1cccc(C(=O)Oc2ccccc2)c1",
        "output": "482"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)Cl.Nc1c(-c2ccccc2)c(=O)[nH]c2cc(Cl)ccc12.[H-].[Na+]>>CC(=O)Nc1c(-c2ccccc2)c(=O)[nH]c2cc(Cl)ccc12",
        "output": "9"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCCNc1ccc(Nc2ncnc(OC3CCN(C(=O)OC(C)C)CC3)c2OC)c(C)n1.C[Si](C)(C)I.ClCCl>>COc1c(Nc2ccc(NCCO)nc2C)ncnc1OC1CCN(C(=O)OC(C)C)CC1",
        "output": "423"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cn1cnc(-c2nccc3c(O)nc(Cl)nc23)c1.OCC1CCOC1>>Cn1cnc(-c2nccc3c(O)nc(OCC4CCOC4)nc23)c1",
        "output": "37"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.OCCCCC=CCCc1ccc(OCc2ccccc2)cc1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCCCCC=CCCc2ccc(OCc3ccccc3)cc2)cc1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)O.CN.Cl>>CNC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)c1c[nH]c(COCc2ccccc2)n1.CCO.CCO.Cl.[Pd]>>CC(C)c1c[nH]c(CO)n1",
        "output": "178"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1cccc(OCCOCCOC(C)=O)c1.CO.O=C([O-])[O-].[K+].[K+]>>CCCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1cccc(OCCOCCO)c1",
        "output": "225"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.ClCCl.Nc1cccc(OCCN2CCOCC2)c1.O=Cc1cnn2ccc(Cl)nc12>>O=Cc1cnn2ccc(Nc3cccc(OCCN4CCOCC4)c3)nc12",
        "output": "161"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)c1cc(N2CCN(CCCCN)CC2)nc(C(C)(C)C)n1.CO.ClC(Cl)Cl.O=C(n1ccnc1)n1ccnc1.c1ccc(N2CCNCC2)cc1>>CC(C)(C)c1cc(N2CCN(CCCCNC(=O)N3CCN(c4ccccc4)CC3)CC2)nc(C(C)(C)C)n1",
        "output": "734"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CNC1.CC(C)O.CCOC(C)=O.I[Cu]I.Nc1ccc(I)cc1F.O=P([O-])([O-])[O-].OCCO.[K+].[K+].[K+]>>Nc1ccc(N2CCC2)cc1F",
        "output": "931"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1ccc(Br)nc1.OCCOCc1ccccc1>>Brc1ccc(OCCOCc2ccccc2)nc1",
        "output": "551"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCNCCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1.CCN=C=NCCCN(C)C.CN(C)C=O.O.O=C(O)c1cc2cc(Cl)ccc2[nH]1.Oc1cccc2[nH]nnc12>>CCCCCCCN(CCc1csc(SC(C)(C)C(=O)OC(C)(C)C)n1)C(=O)c1cc2cc(Cl)ccc2[nH]1",
        "output": "605"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCO.CCOCC.COCOc1cc(O)c(C(C)=O)c(OCOC)c1.O.O=Cc1ccccc1.[K+].[OH-]>>COCOc1cc(O)c(C(=O)C=Cc2ccccc2)c(OCOC)c1",
        "output": "295"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C#N)(c1ccccc1)c1ccc([N+](=O)[O-])cc1.O=S(=O)(O)O.[Na+].[OH-]>>CC(C(N)=O)(c1ccccc1)c1ccc([N+](=O)[O-])cc1",
        "output": "8"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CN(C)C=O.N.O=C(Cl)C(=O)Cl.O=C(O)c1cc2cc(OC(F)(F)F)ccc2[nH]1>>NC(=O)c1cc2cc(OC(F)(F)F)ccc2[nH]1",
        "output": "136"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.CN(C)C=O.O=C([O-])[O-].Oc1cccc(I)c1.[K+].[K+]>>CC(=O)Oc1cccc(I)c1",
        "output": "111"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CO.Cc1cccc(C(=O)O)c1N.N.On1nnc2ccccc21>>Cc1cccc(C(N)=O)c1N",
        "output": "358"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1CO.CCN(CC)CC.CCOCC.ClCCl.O.O=S(=O)(Cl)c1ccccc1>>CC(C)(C)OC(=O)N1CCC[C@H]1COS(=O)(=O)c1ccccc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CC1CC1(NC(=O)C1CC(Oc2nc(-c3ccc(OC)cc3)nc3c(C)c(OC)ccc23)CC1C(=O)OC(C)(C)C)C(=O)OCC.CC[SiH](CC)CC.ClCCl.O=C(O)C(F)(F)F>>C=CC1CC1(NC(=O)C1CC(Oc2nc(-c3ccc(OC)cc3)nc3c(C)c(OC)ccc23)CC1C(=O)O)C(=O)OCC",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCBr.CCN(C(C)C)C(C)C.Cc1ccc(Cl)c(-c2ccc(CN3CCN[C@@H](Cc4ccccc4)C3)cc2)c1>>CCN1CCN(Cc2ccc(-c3cc(C)ccc3Cl)cc2)C[C@@H]1Cc1ccccc1",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCc2ccc(C(=O)O)cc21.O.O=C(n1ccnc1)n1ccnc1.[BH4-].[Na+]>>CC(C)(C)OC(=O)N1CCc2ccc(CO)cc21",
        "output": "72"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1cccc2c1-c1ccccc1C21c2ccccc2-c2ccccc21.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].Cc1ccccc1C.Nc1ccccc1-c1ccccc1.[Na+].[Pd+2]>>c1ccc(-c2ccccc2Nc2cccc3c2-c2ccccc2C32c3ccccc3-c3ccccc32)cc1",
        "output": "405"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)Cc1[nH]nc(C(N)=O)c1[N+](=O)[O-].CCO.[Pd]>>CC(C)Cc1[nH]nc(C(N)=O)c1N",
        "output": "628"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccccc1N1CCc2c(Cl)nc3c(OCC(F)(F)F)cccc3c21.NCCCO>>COc1ccccc1N1CCc2c(NCCCO)nc3c(OCC(F)(F)F)cccc3c21",
        "output": "70"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C(O)c1ccc(Cl)cc1Cl.O=S(=O)(O)O.O=[N+]([O-])O>>O=C(O)c1cc([N+](=O)[O-])c(Cl)cc1Cl",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)OC[C@H](Cc1ccccc1)N(C(=O)C1CCOCC1)C2.NO.[Na+].[OH-]>>O=C(NO)c1ccc2c(c1)OC[C@H](Cc1ccccc1)N(C(=O)C1CCOCC1)C2",
        "output": "988"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)CC(Nc1nc(-c2n[nH]c3ncc(F)cc23)ncc1F)C1(C)CCCC1.O.O.[Li+].[OH-]>>CC1(C(CC(=O)O)Nc2nc(-c3n[nH]c4ncc(F)cc34)ncc2F)CCCC1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br.BrCCSc1cccs1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN1CCCC1=O.COC(=O)[C@H]1CNCC[C@H]1CCC(=O)c1ccnc2ccc(OC)cc12.O>>COC(=O)[C@H]1CN(CCSc2cccs2)CC[C@H]1CCC(=O)c1ccnc2ccc(OC)cc12",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "FC(F)(F)c1ccc2nc(Cl)[nH]c2c1.FC(F)(F)c1cccnc1N1CCNCC1>>FC(F)(F)c1ccc2nc(N3CCN(c4ncccc4C(F)(F)F)CC3)[nH]c2c1",
        "output": "36"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)c1csc(N)n1.Cc1c(Cl)cccc1S(=O)(=O)Cl>>Cc1c(Cl)cccc1S(=O)(=O)Nc1nc(C(C)C)cs1",
        "output": "637"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)CC(N)CC(C)(C)N1.CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.ClC(Cl)Cl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.[Na+]>>COc1cc2nccc(Oc3ccc(NC(=O)NC4CC(C)(C)NC(C)(C)C4)cc3)c2cc1OC",
        "output": "913"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N(c1ccc2c(cnn2C(=O)OC(C)(C)C)c1)c1ccnc(Cl)n1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC1(C)OB(c2cccc(CCC(=O)NC3CC3)c2)OC1(C)C.Cl[Pd]Cl.O.[Cs+].[F-].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(C)OC(=O)N(c1ccc2c(cnn2C(=O)OC(C)(C)C)c1)c1ccnc(-c2cccc(CCC(=O)NC3CC3)c2)n1",
        "output": "974"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(O)c1ccc(Oc2ccccc2)cc1.O=S(Cl)Cl>>O=C(Cl)c1ccc(Oc2ccccc2)cc1",
        "output": "3"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc(Br)ccc1C(=O)O.ClCCl.F[P-](F)(F)(F)(F)F.NCC1CC1>>COc1cc(Br)ccc1C(=O)NCC1CC1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrB(Br)Br.CCOC(C)=O.COc1ccc(-c2cc(NC(=NC(=O)c3cn(C)nc3C(F)(F)F)Nc3ccc(F)c(OC)c3F)[nH]n2)cc1F.ClCCl>>Cn1cc(C(=O)N=C(Nc2cc(-c3ccc(O)c(F)c3)n[nH]2)Nc2ccc(F)c(O)c2F)c(C(F)(F)F)n1",
        "output": "20"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)Nc1nc2cc(Br)ncc2nc1Cl.CCN(C(C)C)C(C)C.Cl.Fc1ccc(OC2CCNCC2)c(F)c1>>CC(C)Nc1nc2cc(Br)ncc2nc1N1CCC(Oc2ccc(F)cc2F)CC1",
        "output": "505"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)C(=C(C)NC(=O)C(F)(F)F)c1ccccc1.C[SiH](C)C.O=S([O-])O.[I-].[Na+]>>CC(NC(=O)C(F)(F)F)=C(C(=O)O)c1ccccc1",
        "output": "122"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCCCCCCCBr.CN(C)P(=O)(N(C)C)N(C)C.Cl.O=C(O)c1cccnc1.[Na+].[OH-]>>CCCCCCCCCCCCOC(=O)c1cccnc1",
        "output": "416"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOc1ccc(CC(=O)O)cc1OCC.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl>>CCOc1ccc(CC(=O)Cl)cc1OCC",
        "output": "56"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.COCCc1cc(C(=O)O)c2c(Cl)cccn12.Cl.NCc1cccc(C(F)(F)F)c1Cl.On1nnc2ccccc21>>COCCc1cc(C(=O)NCc2cccc(C(F)(F)F)c2Cl)c2c(Cl)cccn12",
        "output": "790"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cc1cc(C(F)(F)F)cc(Cl)n1.O.Oc1ccc(CCNc2ncnc3scnc23)cc1.[H-].[Na+]>>Cc1cc(C(F)(F)F)cc(Oc2ccc(CCNc3ncnc4scnc34)cc2)n1",
        "output": "516"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1coc(Cn2cc(C3c4ccc(C)cc4C=Cc4oc(CC)nc43)c(=S)[nH]c2=O)n1.CO.O.O.[Li+].[OH-]>>CCc1nc2c(o1)C=Cc1cc(C)ccc1C2c1cn(Cc2nc(C(=O)O)co2)c(=O)[nH]c1=S",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOCC.COc1cccc(O)c1C(C)=O.C[Mg]Br.O.[Cl-].[NH4+]>>COc1cccc(O)c1C(C)(C)O",
        "output": "586"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(Cl)Cl.CN(C)C=O.COc1cc(OC)cc(OC)c1.COc1ccc(CC(=O)O)c(OC)c1.ClCCl.O=S(Cl)Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(CC(=O)c2c(OC)cc(OC)cc2OC)c(OC)c1",
        "output": "435"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)[O-].CC(=O)[O-].Cc1ccccc1B(O)O.ClCCl.FC(F)(F)c1cccc2c(-c3ccccn3)[nH]nc12.[Cu+2].c1ccncc1>>Cc1ccccc1-n1nc2c(C(F)(F)F)cccc2c1-c1ccccn1",
        "output": "925"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CNC1.CC(C)Oc1c(Cl)nc2ccc(C(O)(c3ccc(C(F)(F)F)nc3)c3cncn3C)cc2c1Cl.CN(C)C=O.O=C(O)C(F)(F)F>>CC(C)Oc1c(N2CCC2)nc2ccc(C(O)(c3ccc(C(F)(F)F)nc3)c3cncn3C)cc2c1Cl",
        "output": "220"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.COC(=O)C1CCC(C(=O)N2CCN(c3ccc(C(=O)Nc4cccc(C(C)(C)C)c4)cn3)CC2)CC1.Cc1ccc(NC(=O)c2ccc(N3CCNCC3)nc2)cc1I.O=C(O)CCc1cc(O)no1>>Cc1ccc(NC(=O)c2ccc(N3CCN(C(=O)CCc4cc(O)no4)CC3)nc2)cc1I",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.Cc1cc(O)ccc1Br.[Cl-].[NH4+].c1c[nH]cn1>>Cc1cc(O[Si](C)(C)C(C)(C)C)ccc1Br",
        "output": "746"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCOCC.CN(C)c1ccncc1.ClCCl.OCc1cc(Cl)nc(C(F)(F)F)c1.c1c[nH]cn1>>CC(C)(C)[Si](OCc1cc(Cl)nc(C(F)(F)F)c1)(c1ccccc1)c1ccccc1",
        "output": "602"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.COC(=O)N1CCC(CO)CC1.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>COC(=O)N1CCC(C=O)CC1",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)N(C)C.CCCCO.CCOCC.COc1cc(N)cc(OC)c1OC.Cl.Clc1nccc(Nc2c(Cl)ccc3c2OCO3)n1>>COc1cc(Nc2nccc(Nc3c(Cl)ccc4c3OCO4)n2)cc(OC)c1OC",
        "output": "907"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)CNc1cccc(Cl)c1.NN.O>>NNC(=O)CNc1cccc(Cl)c1",
        "output": "164"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CBr.CN(C)C=O.O=C([O-])[O-].O=C1COc2cccc(O)c2N1.[K+].[K+]>>CCOC(=O)COc1cccc2c1NC(=O)CO2",
        "output": "123"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.Cc1ncc(Br)cc1[N+](=O)[O-].Cl[Sn]Cl.O.O>>Cc1ncc(Br)cc1N",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "N.O=C(O)CC1(NC(=O)c2ccc(N3CC(F)(F)C3)c(OCC3CC3)n2)CCC1.O=C(n1ccnc1)n1ccnc1>>NC(=O)CC1(NC(=O)c2ccc(N3CC(F)(F)C3)c(OCC3CC3)n2)CCC1",
        "output": "313"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.CS(N)(=O)=O.Cl.ClCCl.O=C(O)c1ccc(Nc2cnc(OC(C(F)(F)F)C(F)(F)F)c(Cl)c2)cc1>>CS(=O)(=O)NC(=O)c1ccc(Nc2cnc(OC(C(F)(F)F)C(F)(F)F)c(Cl)c2)cc1",
        "output": "580"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CN(C2CCOCC2)CCN1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc(C)c1O.F[P-](F)(F)(F)(F)F>>COc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCN(C3CCOCC3)CC2)cc(C)c1O",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.O=C(O)CCC(=O)c1ccc(C2CCCCC2)cc1.[C].[O-][Cl+3]([O-])([O-])O.[Pd]>>O=C(O)CCCc1ccc(C2CCCCC2)cc1",
        "output": "92"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN1c2ncc(CCl)cc2C(=O)N(C)c2ccc(Cl)nc21.Oc1ccccc1F>>CCN1c2ncc(COc3ccccc3F)cc2C(=O)N(C)c2ccc(Cl)nc21",
        "output": "678"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.N#Cc1cccc(O)c1.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c(Cl)c1.[K+].[K+]>>N#Cc1cccc(Oc2ccc([N+](=O)[O-])cc2Cl)c1",
        "output": "564"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)N1c2ccc(C(F)(F)F)cc2C(C(O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1CC.CI.CS(C)=O.[K+].[OH-]>>CCOC(=O)N1c2ccc(C(F)(F)F)cc2C(C(OC)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1CC",
        "output": "140"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCCCN.CCN=C=NCCCN(C)C.COc1cc(O)ccc1/C=C/C(=O)O.On1nnc2ccccc21>>CCCCCCCCCNC(=O)/C=C/c1ccc(O)cc1OC",
        "output": "767"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Cl)cc1.Nc1ccc(N2CCC3(CC2)OCCO3)cc1>>CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(N3CCC4(CC3)OCCO4)cc2)cc1",
        "output": "68"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=Cc1cccc(Oc2ccc(C[C@H]3COC(=O)N3)cc2)n1.[BH4-].[Na+]>>O=C1N[C@@H](Cc2ccc(Oc3cccc(CO)n3)cc2)CO1",
        "output": "745"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCCCC.CN(C)C=O.COc1ccc(Cl)c(Cl)c1.ClCCl.[Li]CCCC>>COc1ccc(Cl)c(Cl)c1C=O",
        "output": "239"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC(=O)O.CC(C)(C)OC(=O)N1CCC(N)CC1.CC(C)=O>>CC(C)NC1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "236"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Cc1ccc(N)cc1.Cl>>COc1ccc2nc(Nc3ccc(C)cc3)c3n[nH]cc3c2c1",
        "output": "998"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(N)=NO.O=C(O)C1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)N2CCSC2)C1>>Cc1noc(C2CC(c3ccc(C(F)(F)F)cc3)CN(C(=O)N3CCSC3)C2)n1",
        "output": "728"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CC1(NC(=O)OC(C)(C)C)COC(C)(C)OC1.C#CCCCCCC.Ic1ccc(I)cc1.Ic1ccc2c(c1)CN(C(c1ccccc1)(c1ccccc1)c1ccccc1)C2>>CC(C)(C)OC(=O)NC1(C#Cc2ccc(I)cc2)COC(C)(C)OC1",
        "output": "664"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1cc(-c2nc(CCO)c(C)s2)ccn1.CS(=O)(=O)Cl>>CCc1cc(-c2nc(CCOS(C)(=O)=O)c(C)s2)ccn1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(N=C=O)c1ccccc1.CN1CCC(c2c[nH]c3ccc(N)cc23)CC1>>CC(NC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2c1)c1ccccc1",
        "output": "888"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C1CCOC1.Cc1ccccc1.Nc1ccc(Br)c2cnccc12.O=C=NCc1ccc(Cl)cc1Cl>>O=C(NCc1ccc(Cl)cc1Cl)Nc1ccc(Br)c2cnccc12",
        "output": "888"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)N.CCC(C)c1cccc(C(C)CC)c1N=C=S.Cl>>CCC(C)c1cccc(C(C)CC)c1NC(=S)NC(C)(C)C",
        "output": "113"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(CCNC(=O)c2c[nH]c(=O)o2)CC1.CO.Cl.ClCCl>>O=C(NCCC1CCNCC1)c1c[nH]c(=O)o1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.COCCCN1CCOc2ccc(CO[C@H]3CNCC[C@]3(O)c3ccc(COCCOC)cc3)cc21.Cc1ccc(S(=O)(=O)Cl)cc1.O.O=C([O-])O.[Na+]>>COCCCN1CCOc2ccc(CO[C@H]3CN(S(=O)(=O)c4ccc(C)cc4)CC[C@]3(O)c3ccc(COCCOC)cc3)cc21",
        "output": "99"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCO.O=S(=O)(Nc1ncc(Cl)nc1Cl)c1cccc(Cl)c1Cl>>CCCCOc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl",
        "output": "209"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1ccccc1Oc1ncc(Cl)cc1[N+](=O)[O-].ClCCl.O=C[O-].[NH4+].[Pt]>>COC(=O)c1ccccc1Oc1ncc(Cl)cc1N",
        "output": "269"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)CCCOc1cccc2c1nc(C(F)F)n2-c1nc(OC2CCNCC2)nc(N2CCOCC2)n1.O=S(=O)(Cl)CCl>>CN(C)CCCOc1cccc2c1nc(C(F)F)n2-c1nc(OC2CCN(S(=O)(=O)CCl)CC2)nc(N2CCOCC2)n1",
        "output": "584"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCCN(Cc2c(O)ccc3c2O/C(=C\\c2c[nH]c4ccccc24)C3=O)CC1.Cl.ClCCl>>O=C1/C(=C/c2c[nH]c3ccccc23)Oc2c1ccc(O)c2CN1CCCNCC1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCCC/C=C\\C/C=C\\CCCCCCCCOC(CO[Si](C)(C)C(C)(C)C)CN(C)C.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>CCCCC/C=C\\C/C=C\\CCCCCCCCOC(CO)CN(C)C",
        "output": "708"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Cl.Cc1ccc2c(c1)C(C)(C)CCC2(C)C.ClCCl.O.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C",
        "output": "31"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(O)C(CCCCCl)n1cncn1.CN(C)C=O.O=C([O-])[O-].Oc1ccc(Cl)c(Cl)c1.[K+].[K+]>>CC(C)(C)C(O)C(CCCCOc1ccc(Cl)c(Cl)c1)n1cncn1",
        "output": "74"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(Oc2ccc([N+](=O)[O-])c(C(C)(C)O[SiH2]C(C)(C)C)c2)ccc1NS(=O)(=O)c1ccc(C)cc1.[H][H].[Pd]>>COC(=O)c1cc(Oc2ccc(N)c(C(C)(C)O[SiH2]C(C)(C)C)c2)ccc1NS(=O)(=O)c1ccc(C)cc1",
        "output": "335"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.FC(F)(F)c1ccc(Cl)nc1Cl.FC1(F)CNC1.O>>FC1(F)CN(c2ccc(C(F)(F)F)c(Cl)n2)C1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1ccc2c(C)noc2c1.O.[Na+].[OH-]>>Cc1noc2cc(C(=O)O)ccc12",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C(C)(C)Br.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1cccc(O)c1.[K+].[K+]>>CCOC(=O)C(C)(C)Oc1cccc([N+](=O)[O-])c1",
        "output": "305"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1.O=C(Nc1ccc(CO)c(F)c1)Oc1ccccc1>>O=C(NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1)Nc1ccc(CO)c(F)c1",
        "output": "488"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccnc(N4CCn5c(nnc5C(F)(F)F)C4)c3)sc2c1-c1ccc(Cl)cc1.CN(C)C=O.CO.[Na+].[OH-]>>Cc1cc2nc(-c3ccnc(N4CCn5c(nnc5C(F)(F)F)C4)c3)sc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CS(=O)(=O)c1nc(OCC(F)(F)F)c(C#N)c(N2CCC(c3ccccc3)CC2)n1.CSc1nc(OCC(F)(F)F)c(C#N)c(N2CCC(c3ccccc3)CC2)n1.NCCO.O=C(OO)c1cccc(Cl)c1>>N#Cc1c(OCC(F)(F)F)nc(NCCO)nc1N1CCC(c2ccccc2)CC1",
        "output": "629"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCNc1cccnc1N1CCN(C(=O)c2ccc(C(=O)O)cn2)CC1.COCC(C)N>>CCNc1cccnc1N1CCN(C(=O)c2ccc(C(=O)NC(C)COC)cn2)CC1",
        "output": "674"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)c1nc(C2CCNCC2)no1.CN(C)C=O.Cc1ccccc1.Cl.N#Cc1cc(Br)cnc1Cl.O=C([O-])[O-].[K+].[K+]>>CC(C)c1nc(C2CCN(c3ncc(Br)cc3C#N)CC2)no1",
        "output": "220"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)[C@@H]1CC[C@@H](c2nnc(-c3ccccc3)[nH]2)CC1.NCCN>>NCCNC(=O)[C@@H]1CC[C@@H](c2nnc(-c3ccccc3)[nH]2)CC1",
        "output": "392"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.COc1ccccc1OCCN(CCCc1c[nH]c2ccc(F)cc12)Cc1ccccc1.[Pd]>>COc1ccccc1OCCNCCCc1c[nH]c2ccc(F)cc12",
        "output": "84"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1cc2nc(-c3n[nH]cc3[N+](=O)[O-])[nH]c2cc1C.Nc1cn[nH]c1>>CCc1cc2nc(-c3n[nH]cc3N)[nH]c2cc1C",
        "output": "628"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)(C)S(=O)(=O)Cc1cc(Br)ccc1Cl.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cl[Pd]Cl.[K+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC1(C)OB(c2ccc(Cl)c(CS(=O)(=O)C(C)(C)C)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=C1C[C@H]2[C@H](O)N(NC(=O)OCC(Cl)(Cl)Cl)c3ccc(I)cc3C(=O)N2C1.C=CCOC(=O)N1C[C@H](O)C[C@H]1CO[Si](C)(C)C(C)(C)C.CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@@H](O)CN1C(=O)OCc1ccccc1.CCO.CCOC(C)=O.[Pd]>>CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@@H](O)CN1",
        "output": "428"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](C)(C)Cl.ClCCl.O.Oc1ccc2c(c1)CCCN2.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1ccc2c(c1)CCCN2",
        "output": "746"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COc1cccc(C(=O)c2cc(Br)ccc2N)c1Cl.[BH4-].[Na+]>>COc1cccc(C(O)c2cc(Br)ccc2N)c1Cl",
        "output": "157"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CNC(=O)c1ccccc1Oc1ccccc1.CO.II.[BH4-].[Na+]>>CNCc1ccccc1Oc1ccccc1",
        "output": "215"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CNCCNC.CS(C)=O.Cc1nc2ccc(Br)cc2n1C.N.O=C([O-])[O-].O=c1cc(OCc2ccc(F)cc2)cc[nH]1.[Cu]I.[K+].[K+]>>Cc1nc2ccc(-n3ccc(OCc4ccc(F)cc4)cc3=O)cc2n1C",
        "output": "982"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CC#N.CC(=O)N(C)C.CC(=O)[O-].CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc(Br)cc1OC.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.[Br-].[Na+].[Pd]>>COc1ccc(/C=C/C#N)cc1OC",
        "output": "539"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1ccc(-c2cc(=O)c3c(N)c(F)cc(F)c3o2)cc1F.CN(C)C=O.ClCCCBr.O.[H-].[Na+]>>CC(=O)N(CCCCl)c1ccc(-c2cc(=O)c3c(N)c(F)cc(F)c3o2)cc1F",
        "output": "367"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CC(C)OC(C)C.CCOC(C)=O.CNC(=O)Cc1cc(Cl)ccc1OC.CO.ClCCl>>CNC(=O)Cc1cc(Cl)ccc1O",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCI.CN(C)C=O.C[C@@H]1OC(C)(C)N(C(=O)OC(C)(C)C)[C@H]1CO.[H-].[Na+]>>CCOC[C@H]1[C@H](C)OC(C)(C)N1C(=O)OC(C)(C)C",
        "output": "307"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1cnc(N2CCC(NC3CC3)CC2)cn1.O=C(O)c1ccc(-c2cnco2)c(F)c1>>CCc1cnc(N2CCC(N(C(=O)c3ccc(-c4cnco4)c(F)c3)C3CC3)CC2)cn1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)CC1CCN(C(=O)CC[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3-n3c(CO)ccc32)CC1.CI.O=C(O)CC(O)(CC(=O)O)C(=O)O.[H-].[Na+]>>CCOC(=O)CC1CCN(C(=O)CC[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3-n3c(COC)ccc32)CC1",
        "output": "140"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1=COCCC1.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.OCc1ccc(I)cc1>>Ic1ccc(COC2CCCCO2)cc1",
        "output": "141"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.O.O=Cc1ccc(OC(F)(F)F)cc1.[I-]>>C=Cc1ccc(OC(F)(F)F)cc1",
        "output": "649"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.Nc1ccccc1C=C1c2ccccc2CCc2ccccc21>>CC(=O)Nc1ccccc1C=C1c2ccccc2CCc2ccccc21",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCC(=O)Cl.CCN(CC)CC.COC(C)(C)C.COc1nc2cc([N+](=O)[O-])cc(CN)c2nc1OC.ClCCl>>CCCCC(=O)NCc1cc([N+](=O)[O-])cc2nc(OC)c(OC)nc12",
        "output": "206"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1cc(Br)ccc1N(CCC(F)(F)F)Cc1ccccc1.O=[N+]([O-])c1cc(Br)ccc1N(CCC(F)(F)F)Cc1ccc(Cl)cc1.O=[N+]([O-])c1cc(Br)ccc1N(CCC(F)(F)F)Cc1ccccc1>>Nc1cc(Br)ccc1N(CCC(F)(F)F)Cc1ccc(Cl)cc1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.OC1CCOCC1>>Cc1ccc(S(=O)(=O)OC2CCOCC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)CCCCCCCCCCCOC(c1ccccc1)(c1ccccc1)c1ccccc1.COC(=O)CCCCCCCCOC(c1ccccc1)(c1ccccc1)c1ccccc1.COC(=O)CCCCCOC(c1ccccc1)(c1ccccc1)c1ccccc1>>O=C(O)CCCCCCCCCCCOC(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)c1cnn(C)c1C(=O)O.COc1ccccc1-c1nc2cc(N)ccn2n1>>CCOC(=O)c1cnn(C)c1C(=O)Nc1ccn2nc(-c3ccccc3OC)nc2c1",
        "output": "844"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.CO.NN.O.O=C1c2ccccc2C(=O)N1CCCn1nccn1>>NCCCn1nccn1",
        "output": "242"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(O)CCNCC1.CCNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)NCC(=O)O)c3)ccc21.Cl>>CCNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)NCC(=O)N4CCC(C)(O)CC4)c3)ccc21",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC1(C)Oc2ccc(C(=O)O)cc2O1.CN(C)C1(C(N)c2ccccc2)CCCC1.CN1CCCC1=O.ClCCCl.ClCCl.On1nnc2cccnc21.[N-]=C=O>>CN(C)C1(C(NC(=O)c2ccc3c(c2)OC(C)(C)O3)c2ccccc2)CCCC1",
        "output": "753"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.C1COCCO1.CS(=O)(=O)c1cccc(B(O)O)c1.Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)ncc1Br.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)ncc1-c1cccc(S(C)(=O)=O)c1",
        "output": "833"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CS(=O)(=O)Cl.CS(=O)(=O)O.Nc1ccc(N)c(S(N)(=O)=O)c1.c1ccncc1>>CS(=O)(=O)Nc1ccc(N)c(S(N)(=O)=O)c1",
        "output": "194"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cn2c(-c3cccs3)cnc(N3CCN(C(=O)OC(C)(C)C)CC3)c2n1.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)c1cn2c(-c3cccs3)cnc(N3CCNCC3)c2n1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.C1COCCO1.O=C(c1cc(Br)cc(Br)c1)c1ccnc(Cl)c1>>O=C(c1cc(Br)cc(Br)c1)c1ccnc(N2CCOCC2)c1",
        "output": "220"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.CS(N)(=O)=O.Cc1noc(-c2ccc(-c3ccc(C4(C(=O)O)CC4)cc3)cc2)c1CC(F)(F)CCc1ccccc1.ClCCl.O=S(Cl)Cl.[H-].[Na+]>>Cc1noc(-c2ccc(-c3ccc(C4(C(=O)NS(C)(=O)=O)CC4)cc3)cc2)c1CC(F)(F)CCc1ccccc1",
        "output": "644"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CC1Cc2cc(Br)ccc2-c2cc(=O)c(C(=O)O)cn21.CS(C)=O.O=C(O)[C@@H]1CCCN1.O=C([O-])[O-].[Cu]I.[K+].[K+]>>CC1Cc2cc(N3CCN(C(=O)OC(C)(C)C)CC3)ccc2-c2cc(=O)c(C(=O)O)cn21",
        "output": "294"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)Nc1nc2cc(Cl)ccc2nc1OC.c1ccc(N2CCNCC2)nc1>>COc1nc2ccc(Cl)cc2nc1NC(=O)N1CCN(c2ccccn2)CC1",
        "output": "613"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)[C@@H](CNC(=O)OCC[Si](C)(C)C)C(=O)O.CC1(C)CNCC[C@]1(O)c1ccc(Cl)cc1.CCN(C(C)C)C(C)C.ClCCCl.ClCCl.On1nnc2ccccc21>>CC(C)[C@@H](CNC(=O)OCC[Si](C)(C)C)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COc1cc(C=O)ccc1F.O.[BH4-].[Na+].[Na+].[OH-]>>COc1cc(CO)ccc1F",
        "output": "356"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CSc1ccc([C@@H](CC2CCCC2=O)C(=O)O)cc1Cl.O.O=CO.O=S([O-])[O-].OO.[Na+].[Na+]>>CS(=O)c1ccc([C@@H](CC2CCCC2=O)C(=O)O)cc1Cl",
        "output": "199"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=Cc1ccc(-c2cc(C(N)=O)c(NC(N)=O)[nH]2)cc1.CO.[Pd]>>CCc1ccc(-c2cc(C(N)=O)c(NC(N)=O)[nH]2)cc1",
        "output": "555"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN(C)C=O.Cl.Clc1ccccc1I.Cn1[nH]c(=O)c2c1[C@]1(C)CC[C@H]2C1(C)C.O=C(O)c1ccccn1.O=C([O-])O.[Cu]I.[K+]>>Cn1c2c(c(=O)n1-c1ccccc1Cl)[C@H]1CC[C@]2(C)C1(C)C",
        "output": "901"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCC(O)c2occc2C1.Fc1ccc2ccccc2c1>>CN1CCC(Oc2ccc3ccccc3c2)c2occc2C1",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.ClCCl.N#Cc1ccc(C(=O)Cl)cc1.N#Cc1ccc(C(=O)Nc2ccc(Cl)c(N)c2)cc1>>N#Cc1ccc(C(=O)Nc2ccc(Cl)c(NC(=O)c3ccc(C#N)cc3)c2)cc1",
        "output": "11"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.C1=CCCCC1.COc1cccc(S(=O)(=O)N2c3ccccc3-c3ccc(F)cc3C2C)c1.ClCCl>>CC1c2cc(F)ccc2-c2ccccc2N1S(=O)(=O)c1cccc(O)c1",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cl[Sn](Cl)(Cl)Cl.NC(=O)c1ccc([N+](=O)[O-])cc1F>>NC(=O)c1ccc(N)cc1F",
        "output": "28"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N(Cc1ccccc1)C1CNC1.CCN(CC)CC.ClCCl.O=S(=O)(Cl)c1ccc(F)cc1>>CC(C)(C)OC(=O)N(Cc1ccccc1)C1CN(S(=O)(=O)c2ccc(F)cc2)C1",
        "output": "99"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.COc1ccc2nccc(CCN3CCCC(CN)C3)c2n1.ClCCl.O=Cc1ccc2c(n1)NC(=O)CS2.O=S(=O)([O-])[O-].[BH4-].[Na+].[Na+].[Na+]>>COc1ccc2nccc(CCN3CCCC(CNCc4ccc5c(n4)NC(=O)CS5)C3)c2n1",
        "output": "775"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)n1nc(N)nc1-c1cn2c(n1)-c1cc(Br)ccc1OCC2.O.O=C([O-])[O-].OB(O)c1ccc(Cl)cc1.[Cs+].[Cs+]>>CC(C)n1nc(N)nc1-c1cn2c(n1)-c1cc(-c3ccc(Cl)cc3)ccc1OCC2",
        "output": "837"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCS(N)(=O)=O.CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)O)CC2)nc1C(F)F>>CCCCS(=O)(=O)NC(=O)C1CCN(c2nc(C(F)F)c(C(=O)OCC)cc2C#N)CC1",
        "output": "644"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.CC(C)(C)OC(=O)[C@H](Cc1ccc(Br)nc1)NC(=O)OCC1c2ccccc2-c2ccccc21.CC(C)O.Cc1ccccc1.Cc1ccccc1B(O)O.Cl[Pd]Cl.O=C([O-])[O-].[Na+].[Na+]>>Cc1ccccc1-c1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)OC(C)(C)C)cn1",
        "output": "869"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(N)(CO)c1cccc(Br)c1.O=C([O-])O.O=S(=O)([O-])O.[K+].[Na+]>>CC(C)(C)OC(=O)NC(C)(CO)c1cccc(Br)c1",
        "output": "686"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C=C(C)C(=O)Cl.CCC1(O)CCCCCCC1.CCOCC.O=C([O-])O.[Li]CCCC.[Na+]>>C=C(C)C(=O)OC1(CC)CCCCCCC1",
        "output": "320"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNCC1.Cl.O=C(O)CC(=O)O.O=C=O.O=Cc1ccc(SC(F)(F)F)cc1.c1ccncc1>>O=C(O)C=Cc1ccc(SC(F)(F)F)cc1",
        "output": "12"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cc([N+](=O)[O-])c3[nH]ccc3c2)c(F)c1.CC(C)=O.O.[Cl-].[NH4+].[Zn]>>CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cc(N)c3[nH]ccc3c2)c(F)c1",
        "output": "269"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cl.ClCCl.Nc1ccccc1O.O=C(Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.[Na+].[OH-].c1ccncc1>>O=C(Nc1ccccc1O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "11"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CCCC(F)(F)[C@@H]1N=[N+]=[N-].CO.[H][H].[Pd]>>CC(C)(C)OC(=O)N[C@@H]1CCCC(F)(F)[C@@H]1N",
        "output": "89"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COC(=O)C1CCOc2cc(Oc3ccc(C(=O)Nc4ccc(C(F)(F)F)nc4)cc3)c(C#N)cc21.Cl.[Na+].[OH-]>>N#Cc1cc2c(cc1Oc1ccc(C(=O)Nc3ccc(C(F)(F)F)nc3)cc1)OCCC2C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CN.COc1ccc(Br)cc1Cc1c(CN(CCC(C)C)C(=O)c2ccc(OC)c(OC)c2Cl)nc2ccc(Cl)nn12.CS(C)=O>>CNc1ccc2nc(CN(CCC(C)C)C(=O)c3ccc(OC)c(OC)c3Cl)c(Cc3cc(Br)ccc3OC)n2n1",
        "output": "241"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CC2(CCN1)OCCO2.Cc1ccc(C=O)c(C)c1Br.Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Cc1ccc(C=O)c(C)c1N1CCC2(CC1)OCCO2",
        "output": "294"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC(CCS(N)(=O)=O)c1ccc(Cl)cc1.CO.Cl.ClCCl>>NC(CCS(N)(=O)=O)c1ccc(Cl)cc1",
        "output": "793"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N(CCO)CCC(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cl.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CNC1.On1nnc2cccnc21>>CC(C)(C)OC(=O)N(CCO)CCC(=O)N1CC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C#N)cc1.CN(C)C=O.O.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1",
        "output": "390"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCc1cn(Cc2ccc(OCc3ccc4ccccc4n3)nc2)nc1-c1ccccc1.Cl.[Na+].[OH-]>>O=C(O)CCc1cn(Cc2ccc(OCc3ccc4ccccc4n3)nc2)nc1-c1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(F)cc1C(C)(C)CC(O)(CNc1cc(C)cc2c1cnn2-c1cccc(C(=O)N[C@H](CO)C(=O)O)c1)C(F)(F)F.N>>COc1ccc(F)cc1C(C)(C)CC(O)(CNc1cc(C)cc2c1cnn2-c1cccc(C(=O)N[C@H](CO)C(N)=O)c1)C(F)(F)F",
        "output": "313"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOC(C)=O.CN(C)C=O.OC(c1ncco1)C1CCc2cc(Oc3ccccc3)ccc2C1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OC(c1ncco1)C1CCc2cc(Oc3ccccc3)ccc2C1",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1ccc(N)c(Cl)c1.ClCCl>>Cc1ccc(NS(C)(=O)=O)c(Cl)c1",
        "output": "194"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].Cl.Nc1ccc(OCc2ccccc2)cn1.[Na+]>>Nc1ncc(OCc2ccccc2)cc1Br",
        "output": "292"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CNc1ccc([N+](=O)[O-])c(C)c1.Cc1cc(C(=O)Cl)ccn1.ClCCl.O=S(Cl)Cl>>Cc1cc(C(=O)N(C)c2ccc([N+](=O)[O-])c(C)c2)ccn1",
        "output": "614"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.F[P-](F)(F)(F)(F)F.N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)c1nc2ccccc2s1.O.O=C(O)C1CCc2ccccc2C1>>O=C(NCCCC[C@H](NC(=O)C1CCc2ccccc2C1)C(=O)c1nc2ccccc2s1)OCc1ccccc1",
        "output": "645"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CN(C)C=O.CNC.COc1ncc(S(=O)(=O)N[C@@H]2CC[C@@H](C(=O)N[C@H](C)c3ccc(F)cc3)CC2)cc1Br.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>COc1ncc(S(=O)(=O)N[C@@H]2CC[C@@H](C(=O)N[C@H](C)c3ccc(F)cc3)CC2)cc1N(C)C",
        "output": "597"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CN(CC2CC2)CCN1.O=C(Cl)Oc1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1.[Br-].[K+]>>O=C(Oc1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1)N1CCN(CC2CC2)CC1",
        "output": "219"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cn(Cc2ccc(Cn3cc(C)cn3)cc2)nc1C#N.CO.O.[Li+].[OH-]>>Cc1cnn(Cc2ccc(Cn3cc(C(=O)O)c(C#N)n3)cc2)c1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CSc1ccc(-c2c(C)n[nH]c(=O)c2-c2ncc(Cl)cc2Cl)nc1.O=P(Cl)(Cl)Cl>>CSc1ccc(-c2c(C)nnc(Cl)c2-c2ncc(Cl)cc2Cl)nc1",
        "output": "537"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1ncc2nc(Oc3ccccc3)sc2c1O.CO.C[O-].NCC(=O)O.[Na+]>>O=C(O)CNC(=O)c1ncc2nc(Oc3ccccc3)sc2c1O",
        "output": "977"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOCC.CSC.FB(F)F.O=C(O)CCC1CCCC1.[BH4-].[Na+]>>OCCCC1CCCC1",
        "output": "231"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)CCCC(C)(C)N1.COC(=O)[C@H]1CC[C@@H](n2c(NC(=O)c3ccccc3)nc3ccc(CO)cc32)CC1.ClCCl.O=S(Cl)Cl>>COC(=O)[C@H]1CC[C@@H](n2c(NC(=O)c3ccccc3)nc3ccc(CN4C(C)(C)CCCC4(C)C)cc32)CC1",
        "output": "765"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(C)c(NC(=O)c2cc(-c3cccc(CO)c3)ccc2C)c1C.Cl.[Na+].[OH-]>>Cc1ccc(-c2cccc(CO)c2)cc1C(=O)Nc1c(C)ccc(C(=O)O)c1C",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)c1n[nH]c2c1NCCC2.OB(O)c1cccc(I)c1>>COC(=O)c1nn(-c2cccc(I)c2)c2c1NCCC2",
        "output": "925"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cnn(-c2nc3cc(N(C)C)ccc3c(=O)[nH]2)c1.CCOC(=O)c1cnn(-c2nc3cccc(N(C)C)c3c(=O)[nH]2)c1.CN(C)c1ccc2c(=O)[nH]c(-n3cc(C(=O)O)cn3)nc2c1.[K+].[OH-]>>CN(C)c1cccc2nc(-n3cc(C(=O)O)cn3)[nH]c(=O)c12",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1noc(-c2ccc(Br)cc2)c1CC(=O)NC(C)c1ccccc1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4CC(=O)NC(C)c4ccccc4)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CC[C@H](N)c1nc2cccc(Cl)c2c(=O)n1C1CC1.CO.COCc1nc(-c2c(N)ncnc2Cl)nn1C.ClCCl>>CC[C@H](Nc1ncnc(N)c1-c1nc(COC)n(C)n1)c1nc2cccc(Cl)c2c(=O)n1C1CC1",
        "output": "110"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCN(Cc2cc(OC(F)(F)F)cc3c(=O)[nH]c(N)nc23)CC1.CCS(=O)(=O)c1ccc(Cl)cc1CBr>>CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(N)nc2c(CN3CCN(C(=O)OC(C)(C)C)CC3)cc(OC(F)(F)F)cc2c1=O",
        "output": "389"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CCOc1cc(O)c2c(c1)OC(C)(C)CC2=O.CCOC(C)=O.CI.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>C=CCOc1cc(OC)c2c(c1)OC(C)(C)CC2=O",
        "output": "62"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1cc(Cl)cc2c1OC1CCCCC21.[Na+].[OH-]>>O=C(O)c1cc(Cl)cc2c1OC1CCCCC21",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CO.Cc1cc2c(cc1CC=O)COC2=O.Cl.O=C(Cc1ccc(-n2cnnn2)cc1)N1CCNCC1.[BH3-]C#N.[Na+]>>Cc1cc2c(cc1CCN1CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC1)COC2=O",
        "output": "484"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1=CCC=CC1.CCOC(=O)C1=CN(C(=O)c2ccc(F)cc2)CCc2c1[nH]c1c(OCc3ccccc3)cccc21.[Pd]>>CCOC(=O)C1=CN(C(=O)c2ccc(F)cc2)CCc2c1[nH]c1c(O)cccc21",
        "output": "264"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.Cc1cc(C)cc(Br)c1.Cl.[Mg]>>Cc1cc(C)cc(B(O)O)c1",
        "output": "832"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1sccc1NS(=O)(=O)c1cccc(-c2ccccc2C)c1.[Na+].[OH-]>>Cc1ccccc1-c1cccc(S(=O)(=O)Nc2ccsc2C(=O)O)c1",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCc2c(sc3c2c2ncnn2c(=O)n3Cc2ccc(Cl)cc2)C1.Cl>>O=c1n(Cc2ccc(Cl)cc2)c2sc3c(c2c2ncnn12)CCNC3",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[O-].CN(C)C=O.Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(-c3cn[nH]c3)n2c1.N#CCCCBr.[I-].[K+].[K+]>>Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(-c3cnn(CCCC#N)c3)n2c1",
        "output": "577"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(OCc2noc(-c3ccnc(C#N)c3)n2)CC1.CO.C[Si](C)(C)I.ClC(Cl)Cl.O=S([O-])([O-])=S.[Na+].[Na+]>>N#Cc1cc(-c2nc(COC3CCNCC3)no2)ccn1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CNOC.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)CC1CC1>>CON(C)C(=O)CC1CC1",
        "output": "54"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.COc1cc(Br)ccc1NC(=O)OC(C)(C)C.ClCCl.[K+]>>COc1cc(B2OC(C)(C)C(C)(C)O2)ccc1NC(=O)OC(C)(C)C",
        "output": "942"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(C(C)=O)ccc1O.Cl.NOCc1ccc([N+](=O)[O-])cc1>>COc1cc(/C(C)=N/OCc2ccc([N+](=O)[O-])cc2)ccc1O",
        "output": "212"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COc1ncnc2c1CN(Cc1ccccc1)CC2.[Pd]>>COc1ncnc2c1CNCC2",
        "output": "84"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=C(Cl)N(C)C.CCN(CC)CC.CO.ClCCl.N.O=C(N(Cc1ccnc2ccccc12)[C@H]1CCN[C@H](Cc2ccccc2)C1)C(F)(F)F.O=C(O)Cc1ccc2ccccc2c1>>O=C(Cc1ccc2ccccc2c1)N1CC[C@H](N(Cc2ccnc3ccccc23)C(=O)C(F)(F)F)C[C@H]1Cc1ccccc1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C(NCCC1CCN(c2ccncc2)CC1)c1cccc(-c2nc3c(Cl)cccc3s2)c1.O=C(O)c1cccc(N2Cc3cccc(Cl)c3C2=O)c1.c1cc(N2CCC(C3CCNCC3)CC2)ccn1>>O=C(c1cccc(N2Cc3cccc(Cl)c3C2=O)c1)N1CCC(C2CCN(c3ccncc3)CC2)CC1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(C)=O.COc1cc(OC)nc(C2CCN(c3cnnc(NN)c3Cl)CC2)n1.ClCCl.O.O=C(O)CC1CC1.O=C([O-])O.O=S(Cl)Cl.[Na+]>>COc1cc(OC)nc(C2CCN(c3cnnc(NNC(=O)CC4CC4)c3Cl)CC2)n1",
        "output": "459"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.C[C@@H]1NC(=O)C[C@@]1(O)C1CC1.N#Cc1ccc(Br)cc1Cl.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>C[C@@H]1N(c2ccc(C#N)c(Cl)c2)C(=O)C[C@@]1(O)C1CC1",
        "output": "809"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(C)=O.O=[N+]([O-])c1ccc(-n2ccnc2)cc1.[Pd]>>Nc1ccc(-n2ccnc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=C(C)C(=O)O.O=C(O)c1ccc(OCCCCO)cc1>>C=C(C)C(=O)OCCCCOc1ccc(C(=O)O)cc1",
        "output": "174"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1nc(Cl)cc(Oc2cc(C)c3[nH]c(=O)oc3c2)n1.O.O=c1[nH]c2ncccc2n1C1CCNCC1>>Cc1nc(Oc2cc(C)c3[nH]c(=O)oc3c2)cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)n1",
        "output": "162"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.C1COCCN1.C=CC(=O)OCC.CC(=O)NC[C@H]1CN(c2ccc(N3CCNCC3)c(F)c2)C(=O)O1.CCO.CN(C)c1ccncc1.ClCCl.O=C(O)CCN1CCOCC1>>CC(=O)NC[C@H]1CN(c2ccc(N3CCN(C(=O)CCN4CCOCC4)CC3)c(F)c2)C(=O)O1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "NC(=O)CBr.O=C1S/C(=C\\c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)C(=O)N1C[C@H]1CCCN1>>NC(=O)CN1CCC[C@@H]1CN1C(=O)S/C(=C\\c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)C1=O",
        "output": "443"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1.ClCCl.O=C(OO)c1cccc(Cl)c1>>CCCCCC(O)c1cccc(OCc2ccc3ccccc3[n+]2[O-])c1",
        "output": "262"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC3CCC4(CC3)OCCO4)c2c1C.O.O.[Li+].[OH-]>>Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3OC3CCC4(CC3)OCCO4)c12",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc2c(c1)CCN(CCc1ccc(N)cc1)C2C.Cc1ccccc1.O=CO>>COc1ccc2c(c1)CCN(CCc1ccc(NC=O)cc1)C2C",
        "output": "27"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)CC1OB(O)c2cc(Oc3ccnc(Cl)c3)cc(C)c21.CO.[Na+].[OH-]>>Cc1cc(Oc2ccnc(Cl)c2)cc2c1C(CC(=O)O)OB2O",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1csc(/C=C/c2cn(-c3ccccc3)nc2OCc2ccc(OCc3nc(-c4ccco4)oc3C)c(OC)c2)n1.Cl.O.[Na+].[OH-]>>COc1cc(COc2nn(-c3ccccc3)cc2/C=C/c2nc(C(=O)O)cs2)ccc1OCc1nc(-c2ccco2)oc1C",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Cc2ccc(N)cc2)CC1.CCCCO.ClCCOCCCl.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCC(Cc2ccc(N3CCOCC3)cc2)CC1",
        "output": "640"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccnc(-c3cccc(S(=O)(=O)NC(C)(C)C)c3)c2)n1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccnc(-c3cccc(S(N)(=O)=O)c3)c2)n1",
        "output": "680"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)C(=O)Cl.CN(C)c1ccncc1.CN(c1ccc2c(c1)nc(C(C)(C)C)n2CC1CCCCC1)S(=O)(=O)c1ccc(N)cc1.ClCCl>>CN(c1ccc2c(c1)nc(C(C)(C)C)n2CC1CCCCC1)S(=O)(=O)c1ccc(NC(=O)C(C)(C)C)cc1",
        "output": "9"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1=C(C)C(=O)C(C(CCC(=O)O)c2ccccc2)=C(C)C1=O.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.ClCCl.O=[N+]([O-])OCCCCO>>CC1=C(C)C(=O)C(C(CCC(=O)OCCCCO[N+](=O)[O-])c2ccccc2)=C(C)C1=O",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC1(C)OCC(COc2c(F)c(F)nc(F)c2F)O1.N#Cc1ccc(OCc2ccccc2)c(O)c1>>CC1(C)OCC(COc2c(F)c(F)nc(Oc3cc(C#N)ccc3OCc3ccccc3)c2F)O1",
        "output": "727"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.CC(=O)O.COc1cc(-c2noc(C)n2)c(C(=O)c2ccc(OCc3ccccc3)cc2)c([N+](=O)[O-])c1O>>COc1cc(-c2noc(C)n2)c(C(=O)c2ccc(O)cc2)c([N+](=O)[O-])c1O",
        "output": "23"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.COc1cc(C(F)=C(F)F)ccc1Oc1cccc(F)n1>>Oc1cc(C(F)=C(F)F)ccc1Oc1cccc(F)n1",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(N)(C#N)CF.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CSC(Oc1cc(C)c2ncc(I)cc2c1)C(=O)O.Cl.O.On1nnc2cccnc21.[Cl-].[Na+]>>CSC(Oc1cc(C)c2ncc(I)cc2c1)C(=O)NC(C)(C#N)CF",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)CC(C)c1ccccc1.CC(C)C(=O)Cl>>CC(=O)CC(C)c1ccc(C(=O)C(C)C)cc1",
        "output": "31"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cnn(Cc2ccccc2)c1.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[Li+].[NH4+]>>OCc1cnn(Cc2ccccc2)c1",
        "output": "471"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=O)CCCCCCC(=O)O.CO>>CCC(=O)CCCCCCC(=O)OC",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1nc(N)sc1C(=O)NCc1ccccc1.O=C(Cl)c1ccc(Cl)cc1>>Cc1nc(NC(=O)c2ccc(Cl)cc2)sc1C(=O)NCc1ccccc1",
        "output": "673"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCBr.C=CCOC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OC.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>C=CCOC(=O)N[C@@H](Cc1ccc(OCC=C)cc1)C(=O)OC",
        "output": "77"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)COc1ccc(OCc2ccccc2)c(OC)c1.Cl.[Na+].[OH-]>>COc1cc(OCC(=O)O)ccc1OCc1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1cc(Cl)c(OC)cc1OCCCN1CCC(O)(Cc2ccc(F)cc2)C(C)(C)C1.O.[Li+].[OH-]>>COc1cc(OCCCN2CCC(O)(Cc3ccc(F)cc3)C(C)(C)C2)c(C(=O)O)cc1Cl",
        "output": "222"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.N#CCNC(=O)c1ccc(-c2ccnc(Cl)n2)cc1.Nc1ccc(NCCO)cc1.O>>N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(NCCO)cc3)n2)cc1",
        "output": "808"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CCc1ccc(OC)c(-c2nccs2)c1.CN(C)C=O.ClCCl.O>>CCc1ccc(O)c(-c2nccs2)c1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C(O)c1cnc2c(C(F)(F)F)cccc2c1O.O=S(Cl)Cl>>O=C(Cl)c1cnc2c(C(F)(F)F)cccc2c1O",
        "output": "188"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1cncc(-c2ccc3nccc(-c4ccncc4)c3c2)c1.O=S(=O)(Cl)c1ccc(F)cc1F.c1ccncc1>>O=S(=O)(Nc1cncc(-c2ccc3nccc(-c4ccncc4)c3c2)c1)c1ccc(F)cc1F",
        "output": "554"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)N.CCN(C(C)C)C(C)C.CN(C)C=O.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)COc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3ccccc3n2)c1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CC(C)NC(=O)COc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3ccccc3n2)c1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)c1ccc([N+](=O)[O-])c(Cl)c1.CCOC(C)=O.CCOCC.Cc1ccccc1.FC(F)(F)c1ccccc1[S-].O.[Li+]>>CC(=O)c1ccc([N+](=O)[O-])c(Sc2ccccc2C(F)(F)F)c1",
        "output": "233"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cc2ncnc(Oc3ccc4c(C(=O)O)cccc4c3)c2cc1OC.NCc1ccc(C(=O)Nc2ccc(F)cc2N)cc1>>COc1cc2ncnc(Oc3ccc4c(C(=O)NCc5ccc(C(=O)Nc6ccc(F)cc6N)cc5)cccc4c3)c2cc1OC",
        "output": "753"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "B.CCCC(CCC)CS(=O)c1cccc(C(O)CC#N)c1.CSC>>CCCC(CCC)CS(=O)c1cccc(C(O)CCN)c1",
        "output": "246"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.NN.O.O=C1c2ccccc2C(=O)N1CCCN1CCC[C@H]1COc1ccc(Oc2ccc(Cl)cc2)cc1>>NCCCN1CCC[C@H]1COc1ccc(Oc2ccc(Cl)cc2)cc1",
        "output": "242"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)c1cc(C)n(Cc2ccccc2)c1C(C)C.[Na+].[OH-]>>Cc1cc(C(=O)O)c(C(C)C)n1Cc1ccccc1",
        "output": "152"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCc1cncc(-c2cccc3c(-c4ccc(C(N)=O)c(NC5CCC(O)CC5)c4)nccc23)c1.O=C(O)C(F)(F)F>>NCCc1cncc(-c2cccc3c(-c4ccc(C(N)=O)c(NC5CCC(O)CC5)c4)nccc23)c1",
        "output": "538"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Cl.ClCCN1CCCC1.O=C([O-])[O-].O=[N+]([O-])c1ccc2cn[nH]c2c1.[K+].[K+]>>O=[N+]([O-])c1ccc2cnn(CCN3CCCC3)c2c1",
        "output": "604"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.Nc1cc(Cl)cc(Cl)c1.O.O=Cc1ccc(C(=O)O)cc1>>O=C(O)c1ccc(C=Nc2cc(Cl)cc(Cl)c2)cc1",
        "output": "329"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(C)=O.CCCCCCCCCCI.CCOC(=O)c1ccccc1Oc1ccc(CCCO)c(O)c1.O=C([O-])[O-].[K+].[K+]>>CCCCCCCCCCOc1cc(Oc2ccccc2C(=O)OCC)ccc1CCCO",
        "output": "198"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1cccnc1Nc1ccccc1.[Pd]>>Nc1cccnc1Nc1ccccc1",
        "output": "269"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1Br)CCCC2(O)c1ncc(-c2cc(C)cc(Nc3cc(C(F)(F)F)ccn3)n2)s1.[K+].[OH-]>>Cc1cc(Nc2cc(C(F)(F)F)ccn2)nc(-c2cnc(C3(O)CCCc4c3ccc(C(=O)O)c4Br)s2)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C(O)CCC/C=C\\CCc1ccccc1.O=S(=O)(O)O>>COC(=O)CCC/C=C\\CCc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=C1CC(=P(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)O1>>COC(=O)C(CC(=O)O)=P(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "139"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)[C@H](CNC(=O)c1cc(O)cc(O)c1)NC(=O)c1c(Cl)cc(C(=O)NCc2cccc(O)c2)cc1Cl.O.O.[Li+].[OH-]>>O=C(NCc1cccc(O)c1)c1cc(Cl)c(C(=O)N[C@@H](CNC(=O)c2cc(O)cc(O)c2)C(=O)O)c(Cl)c1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)O)CC1.CCN(CC)CC.CN(C)c1ccncc1.Cc1cccc(N)c1Br.ClCCl.O=S(Cl)Cl.c1ccncc1>>Cc1cccc(NC(=O)C2CCN(C(=O)OC(C)(C)C)CC2)c1Br",
        "output": "365"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCl.O=S(=O)(O)Cl.[Cl-].[NH4+].c1ccc(C2CCCCC2)cc1>>O=S(=O)(Cl)c1ccc(C2CCCCC2)cc1",
        "output": "182"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN1CCNCC1.ClCCl.NC(=O)c1sc(Nc2cc(C=O)ccc2[N+](=O)[O-])nc1-c1cccc(C(F)(F)F)c1.[Na+]>>CN1CCN(Cc2ccc([N+](=O)[O-])c(Nc3nc(-c4cccc(C(F)(F)F)c4)c(C(N)=O)s3)c2)CC1",
        "output": "567"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1ccc(C2CC(C(=O)O)CN(C(=O)N3CCOCC3)C2)cc1.N=C(NO)c1ccc(Cl)cc1>>CCc1ccc(C2CC(c3nc(-c4ccc(Cl)cc4)no3)CN(C(=O)N3CCOCC3)C2)cc1",
        "output": "895"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[O-].COc1cc(Br)ccc1S(C)(=O)=O.C[C@H](N)c1cc2cc(Cl)ccc2[nH]c1=O.Cc1ccccc1.Cl.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COc1cc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ccc1S(C)(=O)=O",
        "output": "519"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cccc(C2=CCC(O)CC2CN(C)C)c1.Cl.[Pd]>>COc1cccc(C2CCC(O)CC2CN(C)C)c1",
        "output": "249"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1c(C(N)=O)[nH]c2c(Br)cc(C#N)cc12.OB(O)c1ccc(F)cc1>>Cc1c(C(N)=O)[nH]c2c(-c3ccc(F)cc3)cc(C#N)cc12",
        "output": "833"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OCC1CC(c2ccc(-c3ccc(N4C[C@H](Cn5ccnn5)OC4=O)cc3F)cc2F)=NO1.CCCC[N+](CCCC)(CCCC)CCCC.ClCCl.[F-]>>O=C1O[C@@H](Cn2ccnn2)CN1c1ccc(-c2ccc(C3=NOC(CO)C3)c(F)c2)c(F)c1",
        "output": "708"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.CO.COC(=O)c1ccc2c(c1)CCC(Oc1ccnc(NC(=O)C3(C)CCNCC3)c1)C2.Cl.ClCCl.ClCCl.[Na+]>>COC(=O)c1ccc2c(c1)CCC(Oc1ccnc(NC(=O)C3(C)CCN(C(C)C)CC3)c1)C2",
        "output": "187"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1cnc(NC(=O)OC(C)(C)C)o1.CO.O.[Li+].[OH-]>>CC(C)(C)OC(=O)Nc1ncc(C(=O)O)o1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1=CCC=CC1.CCO.Cc1cccc(C)c1NC(=O)c1ccc(Nc2nc3c(c(-c4ccccc4)n2)CCN(Cc2ccccc2)C3)cc1.[Pd]>>Cc1cccc(C)c1NC(=O)c1ccc(Nc2nc3c(c(-c4ccccc4)n2)CCNC3)cc1",
        "output": "84"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1ccccn1.O=Cc1ccc(B(O)O)cc1.O=Cc1cccc(B(O)O)c1.O=[N+]([O-])c1ccc(Br)nc1>>O=Cc1ccc(-c2ccc([N+](=O)[O-])cn2)cc1",
        "output": "869"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCSc1ccc(Cl)cc1CN.N#Cc1cc(Cl)ccc1SC1CCCC1>>NCc1cc(Cl)ccc1SC1CCCC1",
        "output": "175"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.O=C(NCCc1ccc2c(c1)c1cc(Cl)cnc1n2S(=O)(=O)c1ccccc1)c1ccccc1.[F-]>>O=C(NCCc1ccc2[nH]c3ncc(Cl)cc3c2c1)c1ccccc1",
        "output": "831"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrC(Br)(Br)Br.C1CCOC1.N#Cc1ccc(CO)c(OCc2ccccc2)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1ccc(CBr)c(OCc2ccccc2)c1",
        "output": "750"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN(C)C=O.COc1ccc(CCl)cc1OC.Cc1ccccc1.O=C([O-])[O-].[K+].[K+].c1ccc(C(CCN2CCNCC2)c2ccccc2)cc1>>COc1ccc(CN2CCN(CCC(c3ccccc3)c3ccccc3)CC2)cc1OC",
        "output": "156"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCCCC.CCN(CCO)c1ccccc1.COCCl>>CCN(CCOCOC)c1ccccc1",
        "output": "598"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CCN(c3ccncc3)CC2)C1.ClCCl.O=C(O)C(F)(F)F>>c1cc(N2CCC3(CCNC3)CC2)ccn1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-c2ccccc2Cl)nc1.O.O.[Li]O>>O=C(O)c1ccc(-c2ccccc2Cl)nc1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)O.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccccn1>>CC(C)(C)OC(=O)Nc1ccccn1",
        "output": "849"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.NN.O.O=C(NCCc1cccc(Cl)c1)c1coc(CN2C(=O)c3ccccc3C2=O)n1>>NCc1nc(C(=O)NCCc2cccc(Cl)c2)co1",
        "output": "242"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)N[C@H]1CCN(C(=O)OC(C)(C)C)C1.CC(Cl)Cl.CN(C)C=O.O=Cc1ccc(F)cc1Cl.O=Cc1ccccc1.[Na+]>>CC(C)N(Cc1ccc(F)cc1Cl)[C@H]1CCN(C(=O)OC(C)(C)C)C1",
        "output": "567"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)Cc1cc(CNC(=O)C2C3CNCC32)nn1-c1ccccc1.CCN(CC)CC.CO.Cl.ClCCl.O=C(Cl)c1ccccc1>>CC(C)Cc1cc(CNC(=O)C2C3CN(C(=O)c4ccccc4)CC32)nn1-c1ccccc1",
        "output": "201"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(CCN1CCCc2cc([N+](=O)[O-])cc(F)c21)C(=O)Oc1ccccc1.[H][H].[Pd]>>CN(CCN1CCCc2cc(N)cc(F)c21)C(=O)Oc1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Fc1ccc(CCN2CCNCC2)cc1.O=C(O)c1ccc2ccccc2n1>>O=C(c1ccc2ccccc2n1)N1CCN(CCc2ccc(F)cc2)CC1",
        "output": "605"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1cccc(N2CCNCC2)c1.CCOC(=O)Nc1nc2cc(OC)c(OC)cc2nc1OC>>COc1cc2nc(NC(=O)N3CCN(c4cccc(Br)c4)CC3)c(OC)nc2cc1OC",
        "output": "613"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.COc1cccc(-c2ccccc2)c1.Cl[Sn](Cl)(Cl)Cl.c1ccccc1>>COc1cc(-c2ccccc2)ccc1C(C)=O",
        "output": "31"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C(=O)CCl.Nc1ncnn2c(C3CCNCC3)cc(-c3cccc(OCc4ccccc4)c3)c12>>CN(C)C(=O)CN1CCC(c2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnn23)CC1",
        "output": "340"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N(C)C.CC(C)(C)OC(=O)N1CCC(N)CC1.FC(F)(F)c1ccc(Cl)nc1.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(Nc2ccc(C(F)(F)F)cn2)CC1",
        "output": "70"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CCOc1cc(OC)c(F)c(Nc2ccc(I)cc2F)c1[N+](=O)[O-].CCO.O.O=S([O-])S(=O)[O-].[Na+].[Na+]>>C=CCOc1cc(OC)c(F)c(Nc2ccc(I)cc2F)c1N",
        "output": "202"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCI.CN(C)C=O.Nc1c(CC(=O)O)cccc1C(=O)c1ccc(Cl)cc1.O.[Na]>>CCOC(=O)Cc1cccc(C(=O)c2ccc(Cl)cc2)c1N",
        "output": "196"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(CCOc2cccc(OS(=O)(=O)c3ccccc3Cl)c2)CC1.Cl>>O=S(=O)(Oc1cccc(OCCN2CCNCC2)c1)c1ccccc1Cl",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(N2S(=O)(=O)c3ccccc3S2(=O)=O)cc1>>O=C(Cl)c1ccc(N2S(=O)(=O)c3ccccc3S2(=O)=O)cc1",
        "output": "448"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)C=O.NC1CCc2ccc(O)cc2C1Cc1ccccc1>>CC(C)(C)OC(=O)NC1CCc2ccc(O)cc2C1Cc1ccccc1",
        "output": "631"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(N3CCCc4ccc(F)cc43)nc2c1.Cl.O.[Na+].[OH-]>>O=C(O)c1ccc2nc(-c3ccc(F)cc3)c(N3CCCc4ccc(F)cc43)nc2c1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.O=C1CCc2ccc3ccccc3c21.[BH4-].[Na+]>>OC1CCc2ccc3ccccc3c21",
        "output": "24"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(S(=O)c2ccc(C)cc2-c2ccc(Cl)c([N+](=O)[O-])c2)c(-c2ccc(Cl)c([N+](=O)[O-])c2)c1.Cc1ccc(S(=O)c2ccc(C)cc2-c2ccc(N)c([N+](=O)[O-])c2)c(-c2ccc(N)c([N+](=O)[O-])c2)c1>>Cc1ccc(S(=O)c2ccc(C)cc2-c2ccc(Cl)c(N)c2)c(-c2ccc(Cl)c(N)c2)c1",
        "output": "204"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.COc1ccc(C2CC(C(F)(F)F)n3nc(-c4ccnc(C(=O)O)c4)cc3N2)cc1OC>>COc1ccc(C2CC(C(F)(F)F)n3nc(-c4ccnc(C(=O)N5CCN(C(=O)OC(C)(C)C)CC5)c4)cc3N2)cc1OC",
        "output": "605"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.COc1ccc(C#N)cc1-c1ccc(C(F)(F)F)cc1.[H][H].[Pd]>>COc1ccc(CN)cc1-c1ccc(C(F)(F)F)cc1",
        "output": "175"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1CCCC1=O.COCCO.N#Cc1ccc(N)cc1Cl.O.[H-].[Na+]>>COCCOc1cc(N)ccc1C#N",
        "output": "57"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CN(C[C@@H]1CC[C@@H](c2nc3ccccc3n2C)CC1)C(=O)OCc1ccccc1.[Pd]>>CNC[C@@H]1CC[C@@H](c2nc3ccccc3n2C)CC1",
        "output": "428"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cc1oc2c(C)c(C)c(NC(=O)c3ccc(F)cc3)c(C)c2c1-c1ccc(F)cc1>>Cc1oc2c(C)c(C)c(NCc3ccc(F)cc3)c(C)c2c1-c1ccc(F)cc1",
        "output": "215"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.COC(=O)c1cnc(C2CCNCC2)nc1.[Na+]>>COC(=O)c1cnc(C2CCN(C)CC2)nc1",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COc1cc2c(Oc3cc(C)c(C)nc3-c3cccc(C)n3)ccnc2cc1O.O=C([O-])[O-].OCCCBr.[K+].[K+]>>COc1cc2c(Oc3cc(C)c(C)nc3-c3cccc(C)n3)ccnc2cc1OCCCO",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(=O)NCC1CCN(S(C)(=O)=O)CC1)C1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>CCN(C(=O)NCC1CCN(S(C)(=O)=O)CC1)C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN(C)C=O.Cl.ClCc1ccc(Cl)c(Cl)c1.O.O=C1CCNCC1>>O=C1CCN(Cc2ccc(Cl)c(Cl)c2)CC1",
        "output": "156"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CNCCNC1.ClCCl.O=[N+]([O-])c1ccc(F)cc1>>O=[N+]([O-])c1ccc(N2CCCNCC2)cc1",
        "output": "26"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=[N+]=[N-].CCOCC.O=C(O)C1CSCON1>>COC(=O)C1CSCON1",
        "output": "60"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)CO.CN(C)C=O.O.O=C(O)Cc1cccc2c(=O)cc(C3=CCCCC3)oc12.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)COC(=O)Cc1cccc2c(=O)cc(C3=CCCCC3)oc12",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCOc1cccc(C(C)O)c1OCC=C.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>C=CCOc1cccc(C(C)=O)c1OCC=C",
        "output": "32"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4nncn4CCC)cc2)CCCN3CC(C)C)cc1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=S([O-])([O-])=S.[Na+].[Na+]>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4nncn4CCC)cc2)CCCN3CC(C)C)cc1",
        "output": "500"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CNS(=O)(=O)c1cncc(Br)c1.CO.N>>NC(=O)CNS(=O)(=O)c1cncc(Br)c1",
        "output": "163"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)C(=O)Cl.CCN(C(C)C)C(C)C.CN(C)C=O.CN1C(=O)C(c2cccc(-c3ccccc3)c2)(C2CCNCC2)N=C1N>>CC(C)C(=O)N1CCC(C2(c3cccc(-c4ccccc4)c3)N=C(N)N(C)C2=O)CC1",
        "output": "125"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.CC(=O)[O-].CC(=O)[O-].Cc1ccc(Br)cc1N.Cc1ccccc1.O.O.O.O=P([O-])([O-])[O-].OB(O)C1CC1.[K+].[K+].[K+].[Pd+2]>>Cc1ccc(C2CC2)cc1N",
        "output": "956"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C=CC(=O)Cl.CCN(C(C)C)C(C)C.c1ccc(Oc2ccc(Nc3cc(NC4CCNC4)ncn3)cc2)cc1>>C=CC(=O)N1CCC(Nc2cc(Nc3ccc(Oc4ccccc4)cc3)ncn2)C1",
        "output": "135"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.ClCCl.N#Cc1ccccc1N.O.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(Oc2ccc3ccccc3c2)cc1>>N#Cc1ccccc1NC(=O)c1ccc(Oc2ccc3ccccc3c2)cc1",
        "output": "50"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1cc(-c2ccc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>Cn1c(C(F)(F)F)ccc(-c2cc(CBr)c(Cl)cc2F)c1=O",
        "output": "29"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cc1ccc(C2(C(=O)O)CC2)cc1.O=S(=O)(O)O>>COC(=O)C1(c2ccc(C)cc2)CC1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1c(OCC)ccn(-c2ccc(F)cc2)c1=O.O.[Li+].[OH-]>>CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(=O)(=O)Cl.Cc1ccc(Sc2ccc(O)cc2)c(Nc2ccnc3nc(C)ccc23)c1>>Cc1ccc(Sc2ccc(OS(C)(=O)=O)cc2)c(Nc2ccnc3nc(C)ccc23)c1",
        "output": "149"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.Cc1ccc(S(=O)(=O)O)cc1.Clc1nccc(-c2cccnc2Cl)n1.Nc1cccc(Cl)c1.O>>Clc1cccc(Nc2nccc(-c3cccnc3Cl)n2)c1",
        "output": "808"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCC(=O)NC1COc2ccc(NS(=O)(=O)c3ccc(C(C)C)cc3)cc2C1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCNC1COc2ccc(NS(=O)(=O)c3ccc(C(C)C)cc3)cc2C1",
        "output": "112"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCCCC2c2coc3cccc-3c2)CC1.O=C(O)c1ccc(-c2ccccc2)cc1>>O=C(N[C@@H]1CC[C@@H](CCN2CCCCC2c2coc3cccc-3c2)CC1)c1ccc(-c2ccccc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1cccc(I)c1OC.ClCCl>>Oc1cccc(I)c1O",
        "output": "19"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.C[Si](C)(C)CCOCCl.Cc1n[nH]c2cc([N+](=O)[O-])ccc12.O.[H-].[Na+]>>Cc1nn(COCC[Si](C)(C)C)c2cc([N+](=O)[O-])ccc12",
        "output": "910"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C[N+](C)(C)C.O=P(Cl)(Cl)Cl.Oc1nc(-c2ccnc(Cl)c2)cc2cnccc12.[Cl-]>>Clc1cc(-c2cc3cnccc3c(Cl)n2)ccn1",
        "output": "41"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.Cc1c(N[C@@H](c2nnc(-c3ccccc3)o2)[C@H](C)O)ccc(C#N)c1Cl.ClCCl.c1ccncc1>>CC(=O)O[C@@H](C)[C@@H](Nc1ccc(C#N)c(Cl)c1C)c1nnc(-c2ccccc2)o1",
        "output": "126"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OCC(=O)c1ccccc1-c1ccc(CBr)cc1.CC(C)(CC(=O)N[C@@H]1CCc2ccccc2NC1=O)NC(=O)OC(C)(C)C>>CC(=O)OCC(=O)c1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)CC(C)(C)NC(=O)OC(C)(C)C)CCc3ccccc32)cc1",
        "output": "688"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCCCC1.CCOC(=O)COC(=O)N1CCN(c2ccc(Cl)nn2)CC1.CCOC(C)=O.OB(O)c1cccc(C(F)(F)F)c1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)COC(=O)N1CCN(c2ccc(-c3cccc(C(F)(F)F)c3)nn2)CC1",
        "output": "866"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCC(C)[BH-](C(C)CC)C(C)CC.CCOC(CC(C(C)=O)c1ccc2c(c1)OCO2)OCC.OO.[Li+].[Na+].[OH-]>>CCOC(CC(c1ccc2c(c1)OCO2)C(C)O)OCC",
        "output": "91"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)C(=O)Cl.CCN(CC)CC.CCOC(C)=O.COC(OC)C(CNC(=O)c1cc2cc(O)cc([N+](=O)[O-])c2[nH]1)SCc1ccccc1>>COC(OC)C(CNC(=O)c1cc2cc(OC(=O)C(C)(C)C)cc([N+](=O)[O-])c2[nH]1)SCc1ccccc1",
        "output": "111"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCC/C=C\\CCCCCCCCCCO.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CCCC/C=C\\CCCCCCCCCC=O",
        "output": "142"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCCCCCO.CCCCCCCCOc1ccc(-c2ncc(O)cc2F)cc1.CCOC(=O)N=NC(=O)OCC.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCCCCCCOc1ccc(-c2ncc(OCCCCCCCC)cc2F)cc1",
        "output": "547"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCCc1nc(CC)c(Br)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.Cl[Pd]Cl.O=C([O-])[O-].OB(O)c1ccc2c(c1)CCO2.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCCc1nc(CC)c(-c2ccc3c(c2)CCO3)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "871"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCCl.O=C=Nc1ccccc1.OC1CN=C(c2ccc(OC(F)(F)F)cc2)OC1c1ccccc1>>O=C(Nc1ccccc1)OC1CN=C(c2ccc(OC(F)(F)F)cc2)OC1c1ccccc1",
        "output": "34"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COc1ccc2c(c1)C(N=[N+]=[N-])CC(C)(C)C2=O.[H][H].[Pd]>>COc1ccc2c(c1)C(N)CC(C)(C)C2=O",
        "output": "562"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.O=[N+]([O-])c1cc2n(n1)CCOC2.[Pd]>>Nc1cc2n(n1)CCOC2",
        "output": "684"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(=O)Oc1ccc2cc(C(O)(c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)C(C)C)ccc2c1.[C].[Pd]>>CC(=O)Oc1ccc2cc(C(O)(c3c[nH]cn3)C(C)C)ccc2c1",
        "output": "838"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)N.CCOC(C)=O.C[C@H](NC(=O)OC(C)(C)C)c1nc2cccc(Cl)c2c(=O)n1CCC1CO1.[Li+].[O-][Cl+3]([O-])([O-])[O-]>>CC(C)NCC(O)CCn1c([C@H](C)NC(=O)OC(C)(C)C)nc2cccc(Cl)c2c1=O",
        "output": "16"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "B.C1CCOC1.CC(C)(C)OC(=O)Nc1ccc(C(=O)O)cc1I>>CC(C)(C)OC(=O)Nc1ccc(CO)cc1I",
        "output": "72"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.Nc1nc(N2CCNCC2)c2nc(-c3ccc(F)cc3)oc2n1.O=C(O)COc1cccc([N+](=O)[O-])c1>>Nc1nc(N2CCN(C(=O)COc3cccc([N+](=O)[O-])c3)CC2)c2nc(-c3ccc(F)cc3)oc2n1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.CO.COc1cc2c(-c3cc4c(Cl)ccnc4n3S(=O)(=O)c3ccc(C)cc3)cn(CCN3CCC(CCO)CC3)c2cc1OC.ClCCl.[K+].[OH-]>>COc1cc2c(-c3cc4c(Cl)ccnc4[nH]3)cn(CCN3CCC(CCO)CC3)c2cc1OC",
        "output": "949"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCO.CCOCC.Clc1cc(Cl)ncn1.Nc1cccc(Br)c1>>Clc1cc(Nc2cccc(Br)c2)ncn1",
        "output": "161"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(=O)(=O)N1CC2(CCNCC2)c2ccccc21.CS(C)=O.Cl.O.O=C(Nc1nc2ccccc2s1)Oc1ccccc1.[Na+].[OH-]>>CS(=O)(=O)N1CC2(CCN(C(=O)Nc3nc4ccccc4s3)CC2)c2ccccc21",
        "output": "525"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOCC.NC[C@@H]1CC[C@@H](C(=O)O)CC1.O.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](C(=O)O)CC1",
        "output": "631"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)O.CCN(CC)C(=O)c1ccc(C(=C2CCN(Cc3ccccc3)CC2)c2ccc(C#N)cc2)cc1.[K+].[OH-]>>CCN(CC)C(=O)c1ccc(C(=C2CCN(Cc3ccccc3)CC2)c2ccc(C(N)=O)cc2)cc1",
        "output": "419"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.NC1CCC(N2CCc3cnc(O)c4cccc2c34)CC1>>CC(=O)NC1CCC(N2CCc3cnc(O)c4cccc2c34)CC1",
        "output": "339"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)Nc1ccc(F)cc1.Cc1ccccc1.O=C(Cl)CCl.c1ccncc1>>CC(C)N(C(=O)CCl)c1ccc(F)cc1",
        "output": "160"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCO.FC(F)(F)c1cccc(N2CCNCC2)c1.O=C([O-])[O-].OC(CCCl)COc1ccccc1.[Na+].[Na+]>>OC(CCN1CCN(c2cccc(C(F)(F)F)c2)CC1)COc1ccccc1",
        "output": "138"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.O=[Mn]=O.OCc1cccc(Oc2ccccc2)c1>>O=Cc1cccc(Oc2ccccc2)c1",
        "output": "179"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Clc1cc(Cl)nc(Cl)n1.Nc1ccc(Cl)c(Cl)c1.O.O=C([O-])[O-].[Na+].[Na+]>>Clc1cc(Nc2ccc(Cl)c(Cl)c2)nc(Cl)n1",
        "output": "161"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCCO.CCCCP(CCCC)CCCC.CCOC(=O)CCc1ccc(O)cc1Oc1ncc(C(F)(F)F)cc1Cl.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CCCCOc1ccc(CCC(=O)OCC)c(Oc2ncc(C(F)(F)F)cc2Cl)c1",
        "output": "478"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cl.O=C(NC(=S)Nc1ncn[nH]1)c1ccccc1.[Na+].[OH-]>>NC(=S)Nc1ncn[nH]1",
        "output": "80"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)N.NC(=O)c1ccc(OCC2CO2)c(I)c1.O=S1(=O)CCCC1>>CC(C)(C)NCC(O)COc1ccc(C(N)=O)cc1I",
        "output": "16"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)C1CCN(c2nc(Nc3ccc(OC)c(OC)c3)c3ncsc3n2)C1.O.[Na+].[OH-]>>COc1ccc(Nc2nc(N3CCC(C(=O)O)C3)nc3scnc23)cc1OC",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)C[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc2C1=O.CCN(CC)CC.CO.Cl.ClCCl.NO.O>>CC1(C)C[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc2/C1=N\\O",
        "output": "212"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN=C=O.COC(COc1ccc(O)cc1)OC.c1ccccc1>>CNC(=O)Oc1ccc(OCC(OC)OC)cc1",
        "output": "104"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(F)=[N+](C)C.ClCCl.Cn1ccc2c(N)cccc2c1=O.F[P-](F)(F)(F)(F)F.O=C(O)CC1CCCCCC1>>Cn1ccc2c(NC(=O)CC3CCCCCC3)cccc2c1=O",
        "output": "365"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)C(C)(Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1.[Li+].[OH-]>>CC(Cc1ccccc1)(NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#Cc1cc(Nc2cc(Oc3ccc(NC(=O)OC(C)(C)C)c4ccccc34)ccn2)cc(C(=O)O)c1.CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COCCOCCOCCN.F[P-](F)(F)(F)(F)F>>C#Cc1cc(Nc2cc(Oc3ccc(NC(=O)OC(C)(C)C)c4ccccc34)ccn2)cc(C(=O)NCCOCCOCCOC)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCC(=O)N(CCN(C)C)Cc1ccccc1-3.ClCCl>>CN(C)CCN1Cc2ccccc2-c2c(C3CCCCC3)c3ccc(C(=O)O)cc3n2CCC1=O",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.C1=CCCCC1.COc1cccc(S(=O)(=O)N2c3cc(F)ccc3-c3cc(F)ccc3C2C)c1.ClCCl>>CC1c2ccc(F)cc2-c2ccc(F)cc2N1S(=O)(=O)c1cccc(O)c1",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COC(=O)c1cn(-c2cc(C(=O)O)ccc2C)nn1.COc1c(N)cc(C(F)(F)F)cc1NS(C)(=O)=O.ClCCCl.O.On1nnc2cccnc21>>COC(=O)c1cn(-c2cc(C(=O)Nc3cc(C(F)(F)F)cc(NS(C)(=O)=O)c3OC)ccc2C)nn1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(OC(c2cc(-c3ccccc3)oc2C)C2CCOCC2)cc1.Cl.O.[Li+].[OH-]>>Cc1oc(-c2ccccc2)cc1C(Oc1ccc(C(=O)O)cc1)C1CCOCC1",
        "output": "222"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1c(C)noc1C.C1CCOC1.CCN(CC)CC.Nc1ccc(Br)cc1I.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Cc1noc(C)c1C#Cc1cc(Br)ccc1N",
        "output": "664"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)Nc1cc(Cl)nc(NC(=O)OC)[n+]1[O-].ClCCl.OC1CCNCC1>>COC(=O)Nc1cc(N2CCC(O)CC2)nc(NC(=O)OC)[n+]1[O-]",
        "output": "162"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "NCCSC1c2ccccc2COc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc21.O=S(=O)(Cl)c1ccccc1>>O=S(=O)(NCCSC1c2ccccc2COc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc21)c1ccccc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1ccc(CBr)cc1.COC(=O)c1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2-c2ccc(Br)cc2)cc1.CS(=O)(=O)c1cccc(B(O)O)c1>>COC(=O)c1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2-c2ccc(-c3cccc(S(C)(=O)=O)c3)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(N)(C#N)Cn1cc2ncc(Br)cc2n1.O=C(Cl)c1ccc(Cl)cc1>>CC(C#N)(Cn1cc2ncc(Br)cc2n1)NC(=O)c1ccc(Cl)cc1",
        "output": "271"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O=C(O)CCC12CC3CC(CC(C3)C1)C2.O=S(=O)(O)O>>COC(=O)CCC12CC3CC(CC(C3)C1)C2",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.NCc1cccc(Sc2ccccc2)c1.Nc1ncccc1C(=O)O.O=C([O-])O.On1nnc2ccccc21.[Na+]>>Nc1ncccc1C(=O)NCc1cccc(Sc2ccccc2)c1",
        "output": "790"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1c(N=C=S)ccc2ocnc12.Cc1ccccc1.NCCN>>CCc1c(NC(=S)NCCN)ccc2ocnc12",
        "output": "113"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.CCO.CCOC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](OCC)C[C@]4(C)[C@H]3[C@H](NC(=O)OCC(Cl)(Cl)Cl)C[C@]12C.c1ccncc1>>CCOC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](OC(C)=O)[C@@H](OCC)C[C@]4(C)[C@H]3[C@H](NC(=O)OCC(Cl)(Cl)Cl)C[C@]12C",
        "output": "254"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1cncc2cc3ccccc3cc12.CCOCC.ClCCl.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1cc(Br)c2cc3ccccc3cc2c1",
        "output": "262"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNCC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.CN(C)C=O.ClCCCOc1ccc(Cn2c3c(c4ccccc42)CCSc2ccccc2-3)cc1.[I-]>>c1ccc2c(c1)SCCc1c-2n(Cc2ccc(OCCCN3CCCCC3)cc2)c2ccccc12",
        "output": "138"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)COc1cc(Cl)ccc1OCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1CC(N)=O.ClCCl.O=C(O)C(F)(F)F>>NC(=O)C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1OCC(=O)O",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C(=O)O)c1cc(C#N)ccc1OCc1ccccc1.ClCCl.O=S(Cl)Cl>>CC(C(=O)Cl)c1cc(C#N)ccc1OCc1ccccc1",
        "output": "53"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NC(CC1CCCC1)C(=O)O.CC(C)COC(=O)Cl.CN1CCOCC1.O.[BH4-].[Na+]>>CC(C)(C)OC(=O)NC(CO)CC1CCCC1",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.ClC(Cl)Cl.Nc1ccc(C(F)(F)F)cc1C(=O)c1ccccc1.O.O=C(Cl)C(Cl)(Cl)Cl>>O=C(c1ccccc1)c1cc(C(F)(F)F)ccc1NC(=O)C(Cl)(Cl)Cl",
        "output": "9"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.CCOC(=O)CCCCC(=O)c1ccc(F)cc1.ClCCl.O=S([O-])[O-].[Na+].[Na+]>>CCOC(=O)CCCC(Br)C(=O)c1ccc(F)cc1",
        "output": "82"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(O)c1c2ccccc2cc2ccccc12.O=S(Cl)Cl>>O=C(Cl)c1c2ccccc2cc2ccccc12",
        "output": "3"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)[C@H](O)CNC(=O)c1ccc(CN(C(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(C3CCCCC3)cc2)cc1.[Na+].[OH-]>>O=C(NC[C@@H](O)C(=O)O)c1ccc(CN(C(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(C3CCCCC3)cc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Cc1nn(C[C@H](C)NC(=O)OC(C)(C)C)c(C)c1S(=O)(=O)c1ccc([N+](=O)[O-])cc1.[H][H].[Ni]>>Cc1nn(C[C@H](C)NC(=O)OC(C)(C)C)c(C)c1S(=O)(=O)c1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)CC(=O)Cl.Cl.O=[N+]([O-])c1ccccc1.Oc1ccc(O)c(O)c1.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(C)CC(=O)c1cc(O)c(O)cc1O",
        "output": "31"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.Cl.Cl.ClCCl.O.O=C(Cl)OCCCCl.c1ccc2c(c1)CC(Nc1ncc3c(n1)CNC3)C2>>O=C(OCCCCl)N1Cc2cnc(NC3Cc4ccccc4C3)nc2C1",
        "output": "219"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC1(C)CN(Cc2ccccc2)CCC1=O.CO.N.[BH4-].[Na+]>>CC1(C)CN(Cc2ccccc2)CCC1N",
        "output": "63"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(C)=O.O=[N+]([O-])c1ccc(S(=O)(=O)N2COCOC2)cc1.[Pd]>>Nc1ccc(S(=O)(=O)N2COCOC2)cc1",
        "output": "401"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.Cl.c1ncn(C2CCC3(CC2)OCCO3)n1>>O=C1CCC(n2cncn2)CC1",
        "output": "251"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.N#Cc1cc(C=O)c(F)cc1C(F)(F)F.N#Cc1ccc(F)c(C=O)c1C(F)(F)F.O.[BH4-].[Cl-].[Na+].[Na+]>>N#Cc1cc(CO)c(F)cc1C(F)(F)F",
        "output": "356"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)C(CC(C)C)C(=O)OC.[K+].[OH-]>>CCOC(=O)C(CC(C)C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NCCCN.CCCCO.CCN(C(C)C)C(C)C.Cc1cccc(-c2cc(Cl)nc(N)n2)c1C>>Cc1cccc(-c2cc(NCCCNC(=O)OC(C)(C)C)nc(N)n2)c1C",
        "output": "166"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[O-].CNC(=O)c1ccc(Br)nc1.C[C@H]1CCCN1[C@H]1CCN(c2ccc3c(c2)CCNCC3)C1.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CNC(=O)c1ccc(N2CCc3ccc(N4CC[C@H](N5CCC[C@@H]5C)C4)cc3CC2)nc1",
        "output": "647"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCO.CCNCC.CS(=O)(=O)c1cccc(Br)c1.Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])O.OCc1ccc(B(O)O)cc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CS(=O)(=O)c1cccc(-c2ccc(CO)cc2)c1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)C=Cc1ccc(OCc2ccccc2)cc1C(=O)O.CN(C)c1ccncc1.C[Si](C)(C)CCO.ClCCCl.ClCCl>>CC(C)(C)OC(=O)C=Cc1ccc(OCc2ccccc2)cc1C(=O)OCC[Si](C)(C)C",
        "output": "33"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)c1cc2ccc(OCC(O)CCl)cc2o1.COc1ccccc1N1CCNCC1>>COc1ccccc1N1CCN(CC(O)COc2ccc3cc(C(C)=O)oc3c2)CC1",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN1CCOCC1.CCN=C=NCCCN(C)C.Cl.ClCCl.O=C(O)c1ccc(F)c(C(F)(F)F)c1Cl.O=C([O-])O.[NH4+].[Na+].[O-]n1nnc2ccccc21>>NC(=O)c1ccc(F)c(C(F)(F)F)c1Cl",
        "output": "358"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1.ClC(Cl)Cl.N#CC=CS(=O)(=O)c1ccc(N)cc1.O.c1ccncc1>>CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(S(=O)(=O)C=CC#N)cc2)cc1",
        "output": "68"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CI.CN(C)C=O.Cc1cccc(N2C[C@H](CCO)N(C(=O)OC(C)(C)C)CC2=O)c1C.[H-].[Na+]>>COCC[C@H]1CN(c2cccc(C)c2C)C(=O)CN1C(=O)OC(C)(C)C",
        "output": "140"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCOC(C)=O.CN(C)C=O.N.O=C(O)c1cc(Br)cc2c(C3CCS(=O)(=O)C3)c[nH]c12.On1nnc2ccccc21>>NC(=O)c1cc(Br)cc2c(C3CCS(=O)(=O)C3)c[nH]c12",
        "output": "704"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CN(C(=O)OC(C)(C)C)c1ccc(C(=O)O)cc1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.Nc1cnc2ccccc2c1>>CN(C(=O)OC(C)(C)C)c1ccc(C(=O)Nc2cnc3ccccc3c2)cc1",
        "output": "759"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)C(=O)Cl.CCN(CC)CC.ClCCl.Nc1ccc(Br)c([N+](=O)[O-])c1>>CC(C)(C)C(=O)Nc1ccc(Br)c([N+](=O)[O-])c1",
        "output": "9"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.COc1ccc(C2C(C(=O)O)C2C(=O)O)cc1>>COc1ccc(C2C3C(=O)OC(=O)C32)cc1",
        "output": "436"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCP(CCCC)CCCC.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.O=C1SC(Cc2ccc(O)cc2)C(=O)N1C(c1ccccc1)(c1ccccc1)c1ccccc1.OCCc1c[nH]c2ccccc12.c1ccccc1>>O=C1SC(Cc2ccc(OCCc3c[nH]c4ccccc34)cc2)C(=O)N1C(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "478"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1c(C2CC2)nc2ncccc2c1Cl.Cc1ccccc1.Nc1cc(N2CCOCC2)ncc1-c1cncnc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1c(C2CC2)nc2ncccc2c1Nc1cc(N2CCOCC2)ncc1-c1cncnc1",
        "output": "922"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.O=C1Nc2cc(Cl)ccc2C1(Cc1cccc(Cl)c1)C1CCNCC1>>CC(=O)N1CCC(C2(Cc3cccc(Cl)c3)C(=O)Nc3cc(Cl)ccc32)CC1",
        "output": "125"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.CC(C)(C)OC(=O)Nc1cc(Cl)c(Cl)cc1[N+](=O)[O-].CS(C)=O>>CC(C)(C)OC(=O)Nc1cc(N2CCCC2)c(Cl)cc1[N+](=O)[O-]",
        "output": "105"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=C(Nc1ccc(OCc2ccccc2)cn1)C(CC1CCCC1)c1ccc(Cl)c(Cl)c1.[Pd]>>O=C(Nc1ccc(O)cn1)C(CC1CCCC1)c1ccc(Cl)c(Cl)c1",
        "output": "264"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc(C2(C#N)CCCCC2)c1.O.[Li+].[OH-]>>N#CC1(c2cccc(C(=O)O)c2)CCCCC1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)CC(=O)Cl.CC(C)c1c(N)nn2cccnc12.ClCCl.c1ccncc1>>CC(C)c1c(NC(=O)CC(C)(C)C)nn2cccnc12",
        "output": "527"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCO.COc1cncc(C#Cc2ccc(F)c([N+](=O)[O-])c2)c1.Cl[Sn]Cl.O.O.[K+].[OH-]>>COc1cncc(C#Cc2ccc(F)c(N)c2)c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCCCC1c1ccc2cnc(Nc3ccc(N4CCOCC4)cc3)nn12.CN1CCN(c2ccc(Nc3ncc4ccc(-c5cccc(N6CCN(C(=O)OC(C)(C)C)CC6)c5)n4n3)cc2)CC1>>CN1CCN(c2ccc(Nc3ncc4ccc(-c5cccc(N6CCNCC6)c5)n4n3)cc2)CC1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.COc1ccc(-c2n[nH]c3ccc(C#N)cc23)cc1OC.Cl.O.[Na+].[OH-]>>COc1ccc(-c2n[nH]c3ccc(C(N)=O)cc23)cc1OC",
        "output": "419"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)C(Cc1ccc(OCCNC(=O)c2ccc(-c3ccc(OC)cc3)nc2)cc1)Oc1ccc(C(C)C)cc1.[Na+].[OH-]>>COc1ccc(-c2ccc(C(=O)NCCOc3ccc(CC(Oc4ccc(C(C)C)cc4)C(=O)O)cc3)cn2)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=N)NO.CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc(Cn2cc3c(n2)N(CC(=O)O)CCCC3=O)cc1.F[P-](F)(F)(F)(F)F.O=C([O-])[O-].[Na+].[Na+]>>COc1ccc(Cn2cc3c(n2)N(Cc2nc(C)no2)CCCC3=O)cc1",
        "output": "924"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCc1ccnc(C(N)=O)c1N.CCOc1ccccc1C(=O)Cl.c1ccncc1>>CCCc1ccnc(C(N)=O)c1NC(=O)c1ccccc1OCC",
        "output": "501"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1CCc2nc(-c3c[nH]c(C)n3)sc2C1.NCCN>>Cc1nc(-c2nc3c(s2)CC(C(=O)NCCN)CC3)c[nH]1",
        "output": "64"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].COc1ccc(Cl)cn1.[Na+]>>COc1ncc(Cl)cc1Br",
        "output": "292"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1ccc(OCC2CC(F)(F)CN2C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1ccc(OCC2CC(F)(F)CN2)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN1C(=O)Cn2cc(C(=O)NCc3ccc(Cl)cc3)c(=O)c3cc(CCl)cc1c32.CNCC(O)c1ccc(O)cc1>>CN(Cc1cc2c3c(c1)c(=O)c(C(=O)NCc1ccc(Cl)cc1)cn3CC(=O)N2C)CC(O)c1ccc(O)cc1",
        "output": "156"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.NC(=O)c1c(N)c2cc([N+](=O)[O-])ccc2n1-c1ccc(Oc2ccccc2)cc1.[Pd]>>NC(=O)c1c(N)c2cc(N)ccc2n1-c1ccc(Oc2ccccc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)c1ccncc1.CS(N)(=O)=O.Cl.O=C(O)c1cccc(Br)c1>>CS(=O)(=O)NC(=O)c1cccc(Br)c1",
        "output": "580"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1c(CCCN(C)C)c[nH]c1C.CN(C)C=O.O=P(Cl)(Cl)Cl>>CCOC(=O)c1c(C)[nH]c(C=O)c1CCCN(C)C",
        "output": "641"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.NC(=O)Cn1ncc([N+](=O)[O-])c1N>>NC(=S)Cn1ncc([N+](=O)[O-])c1N",
        "output": "695"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)N[C@H](CCCNC(=O)OCc1ccccc1)C(=O)O.CC(C)O.CCOC(C)=O.O=[N+]([O-])c1ccccc1O.c1ccncc1>>CC(C)(C)OC(=O)N[C@H](CCCNC(=O)OCc1ccccc1)C(=O)Oc1ccccc1[N+](=O)[O-]",
        "output": "108"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccccc1C(=O)Cl.Nc1cc(C(=O)NCc2ccccc2)ccn1.O=C(Cl)c1ccccc1F>>COc1ccccc1C(=O)Nc1cc(C(=O)NCc2ccccc2)ccn1",
        "output": "463"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.NCc1ccc(CN(Cc2ccccn2)S(=O)(=O)c2ccccc2[N+](=O)[O-])cc1.O=C1CCc2cccc(O)c2C1.[Na+]>>O=[N+]([O-])c1ccccc1S(=O)(=O)N(Cc1ccc(CNC2CCc3cccc(O)c3C2)cc1)Cc1ccccn1",
        "output": "589"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Cl.CN1C(=O)CCc2cc(-c3cncc(O[C@H]4CCNC4)c3)ccc21.Cl>>CC(=O)N1CC[C@H](Oc2cncc(-c3ccc4c(c3)CCC(=O)N4C)c2)C1",
        "output": "125"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CI.CN(C)C=O.Cc1cc2ccccc2n1C(C)(C)CO.[H-].[Na+]>>COCC(C)(C)n1c(C)cc2ccccc21",
        "output": "140"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCOc1cc(C=O)ccc1OC.CCO>>CCCOc1cc(CO)ccc1OC",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)CCc1ccc(O)c(C)c1C.CCOC(=O)CCc1ccc(OCc2c(-c3ccc(CC)cc3)csc2C(F)(F)F)c(C)c1C.CCc1ccc(-c2csc(C(F)(F)F)c2COS(C)(=O)=O)cc1>>CCc1ccc(-c2csc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.OC(CCCCl)c1cccs1.Oc1cc(Cl)ccc1Cl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>ClCCCC(Oc1cc(Cl)ccc1Cl)c1cccs1",
        "output": "550"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)[O-].CN1CCNCC1.COc1cc(Br)ccc1-c1nc2c(c(C3CCCCC3)nn2C)c(=O)[nH]1.Cc1ccccc1.O.[Na+].[Pd+2]>>COc1cc(N2CCN(C)CC2)ccc1-c1nc2c(c(C3CCCCC3)nn2C)c(=O)[nH]1",
        "output": "294"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)[O-].CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)[O-].Cl.O=P([O-])([O-])[O-].[Ca+2]>>CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)O",
        "output": "151"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1cc(-c2cccc(-n3c(C)ccc3C)n2)c(OC)cc1OCc1ccccc1.CO.O=C[O-].[NH4+].[OH-].[OH-].[Pd+2]>>CCc1cc(-c2cccc(-n3c(C)ccc3C)n2)c(OC)cc1O",
        "output": "23"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNC(=O)C1(NC(=O)OC(C)(C)C)CCOCC1.ClCCl.O=C(O)C(F)(F)F>>CNC(=O)C1(N)CCOCC1",
        "output": "431"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COc1ccc(-c2nc3c(C(N)=O)cccc3s2)cc1.Cl.ClCCl>>NC(=O)c1cccc2sc(-c3ccc(O)cc3)nc12",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.ClCCl.O=S(Cl)Cl.[N-]=[N+]=NCc1ccccc1CC(=O)O>>[N-]=[N+]=NCc1ccccc1CC(=O)Cl",
        "output": "53"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CN1CC[C@H](C)N2C(=O)c3c(OCc4ccccc4)c(=O)c(C(=O)NCc4ccc(F)cc4)cn3C[C@@H]12.CC(C)CNCC[C@H](C)N.COC(=O)c1c(OCc2ccccc2)c(=O)c(C(=O)NCc2ccc(F)cc2)cn1CC=O.Cl.Cl>>CC(C)CN1CC[C@H](C)N2C(=O)c3c(O)c(=O)c(C(=O)NCc4ccc(F)cc4)cn3C[C@@H]12",
        "output": "264"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#C[Si](C)(C)C.CCN(CC)CC.CCc1ccc(I)cc1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.I[Cu]I>>CCc1ccc(C#C[Si](C)(C)C)cc1",
        "output": "826"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Cl.NC(Cc1ccc(Br)cc1)C(=O)O>>COC(=O)C(N)Cc1ccc(Br)cc1",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.CS[C@H]1O[C@@H](c2ccc(C)c(Cc3ccc(CCCCO)cc3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.ClCCl>>CS[C@H]1O[C@@H](c2ccc(C)c(Cc3ccc(CCCCOS(C)(=O)=O)cc3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.O=C(Nc1cc(Oc2ccc([N+](=O)[O-])cc2)ccn1)N1CCC(CN2CCC2)CC1.[C].[Pd]>>Nc1ccc(Oc2ccnc(NC(=O)N3CCC(CN4CCC4)CC3)c2)cc1",
        "output": "335"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(-c2nc3cc4c(cc3[nH]2)C(C)(C)C(=O)N4CC(=O)c2ccccc2)cc1.O=C(O)C(F)(F)F>>COc1ccc(-c2nc3cc4c(cc3[nH]2)C(C)(C)C(=O)N4CC(O)c2ccccc2)cc1",
        "output": "24"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cc1ccccc1N1CCNCC1.Clc1ccc(-c2ccn(CC3CO3)n2)cc1Cl>>Cc1ccccc1N1CCN(CC(O)Cn2ccc(-c3ccc(Cl)c(Cl)c3)n2)CC1",
        "output": "76"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1ccc(Br)nc1.C#CCO.CCNCC.[Cu]I>>OCC#Cc1ccc(Br)cn1",
        "output": "777"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CI.O=C([O-])[O-].Oc1ccc2c(c1)OCCO2.[K+].[K+]>>COc1ccc2c(c1)OCCO2",
        "output": "62"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCI.CN(C)C=O.C[C@@H](COc1ccc(-c2nc3ccc(O)cc3o2)nc1)NC(=O)OC(C)(C)C.O.O=C([O-])[O-].[K+].[K+]>>CCOc1ccc2nc(-c3ccc(OC[C@H](C)NC(=O)OC(C)(C)C)cn3)oc2c1",
        "output": "198"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.CCN(CC)CC.Clc1ccc(NCc2cccnc2)cc1>>CC(=O)N(Cc1cccnc1)c1ccc(Cl)cc1",
        "output": "160"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.N#Cc1cnc(Cl)nc1Cl.NCCc1c[nH]c2ccccc12>>N#Cc1cnc(NCCc2c[nH]c3ccccc23)nc1Cl",
        "output": "544"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCNCC.CCOC(C)=O.N#CCC(=O)O>>CCN(CC)C(=O)CC#N",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.CCN1C(=O)CCCc2cc(N)c(OC)cc21.CN([C@@H]1CCCC[C@H]1Nc1nc(Cl)ncc1Cl)S(C)(=O)=O.O=C([O-])[O-]>>CCN1C(=O)CCCc2cc(Nc3ncc(Cl)c(N[C@@H]4CCCC[C@H]4N(C)S(C)(=O)=O)n3)c(OC)cc21",
        "output": "808"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.Cl[Pd]Cl.O.O=C(O)c1n[nH]c2ccc(Br)cc12.O=C([O-])[O-].OB(O)c1ccccc1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=C(O)c1n[nH]c2ccc(-c3ccccc3)cc12",
        "output": "837"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cccc(N=C=O)c1.NCCC(=O)N(c1ccccc1)c1ccccc1>>Cc1cccc(NC(=O)NCCC(=O)N(c2ccccc2)c2ccccc2)c1",
        "output": "35"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCBr.CCN(CC)CC.NCCCCC1(C(N)=O)c2ccccc2-c2ccccc21.c1ccccc1>>CCCNCCCCC1(C(N)=O)c2ccccc2-c2ccccc21",
        "output": "147"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCc1cnc(-c2ccc(O)cc2)nc1.FC(F)(COCCCCl)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>CCCCCCCc1cnc(-c2ccc(OCCCOCC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc2)nc1",
        "output": "74"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1ccc2ncc(C#N)c(-c3cccnc3)c2c1.[H-]>>N#Cc1cnc2ccc(CO)cc2c1-c1cccnc1",
        "output": "311"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNCC1.O=S1(=O)N=C(c2ccc(Cl)cc2)c2ccc(OCCCCBr)cc21>>O=S1(=O)N=C(c2ccc(Cl)cc2)c2ccc(OCCCCN3CCCCC3)cc21",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.CO.CO.COC(=O)[C@@H](NC(=O)c1ccc(Sc2ccc(CN3CCOCC3)cc2)cc1)[C@@H](C)O.C[O-].Cl.Cl.NO.[Na+]>>C[C@@H](O)[C@H](NC(=O)c1ccc(Sc2ccc(CN3CCOCC3)cc2)cc1)C(=O)NO",
        "output": "376"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCCOCCBr.O=C1Nc2ccccc2C1C1CCNCC1>>CCOCCOCCN1CCC(C2C(=O)Nc3ccccc32)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.CN1CCOCC1.COc1ccc(C(=O)O)c(N)c1.Cl.Oc1cccc2[nH]nnc12.[NH4+].[OH-]>>COc1ccc(C(N)=O)c(N)c1",
        "output": "358"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(O)Cn1ccc(N)n1.CCN=C=NCCCN(C)C.CN(c1ccccc1)c1cnn(C(CC2CCCC2)C(=O)O)c(=O)c1.ClCCl.On1nnc2ccccc21>>CN(c1ccccc1)c1cnn(C(CC2CCCC2)C(=O)Nc2ccn(CC(C)(C)O)n2)c(=O)c1",
        "output": "795"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.COc1ccc2ccc(=O)n(CC=O)c2c1.ClCCl.O=C(NC[C@H]1CNC[C@H]1O)OCc1ccccc1.O=C([O-])[O-].[Na+].[Na+].[Na+]>>COc1ccc2ccc(=O)n(CCN3C[C@@H](O)[C@@H](CNC(=O)OCc4ccccc4)C3)c2c1",
        "output": "484"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)Cl.CCOC(C)=O.ClCCl.N#Cc1ccc2cc(N)cc(-c3cccc4ccccc34)c2n1.O=C(O)CC(O)(CC(=O)O)C(=O)O.c1ccncc1>>CCOC(=O)Nc1cc(-c2cccc3ccccc23)c2nc(C#N)ccc2c1",
        "output": "102"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COCCOC.O=C(O)CCc1ccc(B(O)O)cc1.O=C(O)c1ccc(Br)cn1.O=C([O-])[O-].[Na+].[Na+]>>O=C(O)CCc1ccc(-c2ccc(C(=O)O)nc2)cc1",
        "output": "833"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1NCCc2c(Br)cccc21.O=C(O)c1cc2ncc(Cl)cn2n1>>CC1c2cccc(Br)c2CCN1C(=O)c1cc2ncc(Cl)cn2n1",
        "output": "952"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)C1(C(=O)OCC)CC(O)C1.CS(=O)(=O)Cl.c1ccncc1>>CCOC(=O)C1(C(=O)OCC)CC(OS(C)(=O)=O)C1",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(=O)/C=C/c1cnc(N[C@@H]2CCNC2)c(Cl)c1.Cl.Cl.ClCCl.O.O=C(Cl)c1ccccc1>>CCOC(=O)/C=C/c1cnc(N[C@@H]2CCN(C(=O)c3ccccc3)C2)c(Cl)c1",
        "output": "201"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1C(=O)N(C(=O)[C@H](C)N)c2cccc(N)c2-c2ccccc21.C[C@](O)(C(=O)O)c1ccccc1>>CC1C(=O)N(C(=O)[C@H](C)NC(=O)[C@](C)(O)c2ccccc2)c2cccc(N)c2-c2ccccc21",
        "output": "133"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CCOCC.CO.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[N-]=[N+]=NC1CCN2c3ccccc3Cc3ccccc3C2C1>>NC1CCN2c3ccccc3Cc3ccccc3C2C1",
        "output": "89"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NCCC(N)c1ccccc1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc2cc(C(=O)Nc3cc(C(=O)O)ccc3Cl)c(=O)[nH]c2n1.F[P-](F)(F)(F)(F)F>>COc1ccc2cc(C(=O)Nc3cc(C(=O)NC(CCNC(=O)OC(C)(C)C)c4ccccc4)ccc3Cl)c(=O)[nH]c2n1",
        "output": "753"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)c1cccc(-n2c(C)nc3ccc(C(F)(F)F)cc32)c1C.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>Cc1c(CO)cccc1-n1c(C)nc2ccc(C(F)(F)F)cc21",
        "output": "444"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Fc1nc(F)c(Cl)cc1Cl.O.OCCCCO.OCCO.[Na+].[OH-]>>OCCCCOc1nc(F)c(Cl)cc1Cl",
        "output": "541"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1ccc(C#Cc2cc3c(cc2F)SC(C)(C)C=C3c2ccc(C)s2)cc1.Cl.[Na+].[OH-]>>Cc1ccc(C2=CC(C)(C)Sc3cc(F)c(C#Cc4ccc(C(=O)O)cc4)cc32)s1",
        "output": "5"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.Cc1scnc1CN(C(=O)OC(C)(C)C)c1nn(C(=O)OC(C)(C)C)c2cc(N)ccc12.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(-c2ccc(Cl)cc2)s1>>Cc1scnc1CN(C(=O)OC(C)(C)C)c1nn(C(=O)OC(C)(C)C)c2cc(NC(=O)c3ccc(-c4ccc(Cl)cc4)s3)ccc12",
        "output": "822"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.COc1ccc(C2CNC(=O)C2)cc1.II.O.O=S(=O)(O)O.[O-][I+2]([O-])O>>COc1ccc(C2CNC(=O)C2)cc1I",
        "output": "372"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.N#Cc1cccc(-n2ccc3c(=O)n(CC4(O)CCN(C(=O)c5ccc(F)cc5)CC4)cnc32)c1.[Li+].[Ni].[OH-].[Pd]>>NCc1cccc(-n2ccc3c(=O)n(CC4(O)CCN(C(=O)c5ccc(F)cc5)CC4)cnc32)c1",
        "output": "175"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=C(O)c1nc(C2CC2)nc(NCc2ccccc2)c1Cl.O=C([O-])O.O=S(Cl)Cl.[Na+]>>CCOC(=O)c1nc(C2CC2)nc(NCc2ccccc2)c1Cl",
        "output": "331"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.COC(=O)c1ccc2c(=O)n(-c3ccccc3)c(Cl)nc2c1.NCc1ccc(Cl)cc1>>COC(=O)c1ccc2c(=O)n(-c3ccccc3)c(NCc3ccc(Cl)cc3)nc2c1",
        "output": "364"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.CN(C)C(=O)Oc1cccc(NC(=O)C2(COCc3ccccc3)CCN(C(=O)OC(C)(C)C)CC2)c1.Cl.O=C([O-])O.[Na+]>>CN(C)C(=O)Oc1cccc(NC(=O)C2(COCc3ccccc3)CCNCC2)c1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3O[C@@H]3CCCOC3)c12.NCCCN1CCCC1>>Cc1c(C(=O)NCCCN2CCCC2)sc2ncnc(Nc3ccc(F)cc3O[C@@H]3CCCOC3)c12",
        "output": "736"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCO.Cc1c(-c2cc3cc(C=C4SC(=O)NC4=O)ccc3o2)oc(=O)c(C)c1O.[H][H].[Pd]>>Cc1c(-c2cc3cc(CC4SC(=O)NC4=O)ccc3o2)oc(=O)c(C)c1O",
        "output": "762"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(Cl)cc1C(=O)Cl.COc1ccc2c(c1)OCC(N)C2.Cl.c1ccncc1>>COc1ccc2c(c1)OCC(NC(=O)c1cc(Cl)ccc1OC)C2",
        "output": "271"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCNCC2)c1.Cn1nc(C(F)(F)F)cc1-c1ccc(C=O)s1>>CC(C)C(=O)Nc1cccc(C2CCN(Cc3ccc(-c4cc(C(F)(F)F)nn4C)s3)CC2)c1",
        "output": "792"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)Cc1cc(CNC(=O)C2C3CNCC32)nn1-c1ccccc1.CCCCCC.CCN(CC)CC.CCOC(C)=O.Cl.ClCCl.O=S(=O)(Cl)c1ccccc1>>CC(C)Cc1cc(CNC(=O)C2C3CN(S(=O)(=O)c4ccccc4)CC32)nn1-c1ccccc1",
        "output": "99"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc(Oc2ccc(C(=O)O)cc2)cc1.ClCCl.O=C(Cl)C(=O)Cl>>Cc1ccc(Oc2ccc(C(=O)Cl)cc2)cc1",
        "output": "448"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1cn2ccnc(N3CCOCC3)c2n1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1cn2ccnc(N3CCOCC3)c2n1",
        "output": "286"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COCCCN1C(=O)C(C)(C)Oc2ccc(CCl)cc21.COc1ccc(C2CCN(C(=O)OCc3ccccc3)CC2O)cc1>>COCCCN1C(=O)C(C)(C)Oc2ccc(COC3CN(C(=O)OCc4ccccc4)CCC3c3ccc(OC)cc3)cc21",
        "output": "208"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CNCCN1.CN1CCCC1=O.COc1ccnc(Cl)c1.O>>COc1ccnc(N2CCNCC2)c1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1CC(=O)O.ClCCl.O[C@@H]1CCNC1.On1nnc2ccccc21>>Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1CC(=O)N1CC[C@@H](O)C1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[Si](C)(C)CCOCn1cc(C(=O)O)c(-c2nc3c(s2)CCC3)n1.F[P-](F)(F)(F)(F)F.NC1CCOCC1>>C[Si](C)(C)CCOCn1cc(C(=O)NC2CCOCC2)c(-c2nc3c(s2)CCC3)n1",
        "output": "621"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCOc1cccc(C(=O)Cl)c1.CCN(CC)CC.ClCCl.Nc1ccc([N+](=O)[O-])cc1C(=O)O>>CCCCCCCCCCOc1cccc(C(=O)Nc2ccc([N+](=O)[O-])cc2C(=O)O)c1",
        "output": "11"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.COc1ncc(CNc2cccc(F)n2)cc1F.O=C([O-])[O-].O=C1CCC(=O)N1Br.[K+].[K+]>>COc1ncc(CNc2ccc(Br)c(F)n2)cc1F",
        "output": "518"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)c1cc(-c2ccc(N)cc2)no1.O=C=Nc1ccccc1F>>CCOC(=O)c1cc(-c2ccc(NC(=O)Nc3ccccc3F)cc2)no1",
        "output": "473"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COc1ccc(Cl)cc1S(=O)(=O)N[C@@H]1C[C@H](CN)N(C(=O)OC(C)(C)C)C1.ClCCl.O=C(Cl)Oc1ccccc1>>COc1ccc(Cl)cc1S(=O)(=O)N[C@@H]1C[C@H](CNC(=O)Oc2ccccc2)N(C(=O)OC(C)(C)C)C1",
        "output": "94"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.CSc1ccsc1C=O.[BH4-].[Na+]>>CSc1ccsc1CO",
        "output": "529"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(c1ccc(-c2cc3ccc(OCCCNC(=O)OC(C)(C)C)cc3cc2O)nn1)C1CC(C)(C)NC(C)(C)C1.CO.ClCCl.O=C(O)C(F)(F)F>>CN(c1ccc(-c2cc3ccc(OCCCN)cc3cc2O)nn1)C1CC(C)(C)NC(C)(C)C1",
        "output": "538"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.Cl.Nc1cc([N+](=O)[O-])c([N+](=O)[O-])cc1N.O.O=C(O)C(O)C(F)(F)F.O=C([O-])O.[Na+]>>O=[N+]([O-])c1cc2nc(C(O)C(F)(F)F)[nH]c2cc1[N+](=O)[O-]",
        "output": "512"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cc1ncnc2c1c(NCc1ccccc1C(F)(F)F)cc(=O)n2OCc1ccccc1.[C].[H][H].[OH-].[OH-].[Pd+2]>>Cc1ncnc2c1c(NCc1ccccc1C(F)(F)F)cc(=O)n2O",
        "output": "630"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN.CN(C)C=O.Cl.ClCCl.O.O=C(O)Cc1ccccc1O.On1nnc2ccccc21>>CNC(=O)Cc1ccccc1O",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1ccccc1S(N)(=O)=O.O=C1CCC(=O)N1I>>Nc1ccc(I)cc1S(N)(=O)=O",
        "output": "834"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(F)(C(=O)O)c1ccc(OS(=O)(=O)C(F)(F)F)cc1.CON.Cl.O=S(Cl)Cl>>CONC(=O)C(C)(F)c1ccc(OS(=O)(=O)C(F)(F)F)cc1",
        "output": "480"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClC(Cl)Cl.O=C(Cl)OCc1ccccc1.O=C([O-])O.OCC1CCCNC1.[Na+]>>O=C(OCc1ccccc1)N1CCCC(CO)C1",
        "output": "427"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C(=O)Cl.C[Si](C)(C)C#N.ClCCl.O=C([O-])[O-].[K+].[K+].[O-][n+]1cccc(Br)c1>>N#Cc1ncccc1Br",
        "output": "720"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCc2cccc(C(=O)O)c21.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COC(=O)c1ccc([C@H](C)[NH3+])cc1.F[P-](F)(F)(F)(F)F.[Cl-]>>COC(=O)c1ccc([C@H](C)NC(=O)c2cccc3c2N(C(=O)OC(C)(C)C)CC3)cc1",
        "output": "753"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CC(=O)Cl.CC(=O)N[C@H]1[C@@H](NC(=O)CCCCCN)O[C@H](CO)[C@H](O)[C@@H]1O.Cl.O.[Na+].[OH-]>>C=CC(=O)NCCCCCC(=O)N[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1NC(C)=O",
        "output": "298"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(-c2nc3ccccc3o2)c(F)c1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>Fc1cc(CBr)ccc1-c1nc2ccccc2o1",
        "output": "29"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4Nc4cccc(Br)n4)cc3)cc2)CC1.OB(O)c1cccc(Cl)c1Cl>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4Nc4cccc(-c5cccc(Cl)c5Cl)n4)cc3)cc2)CC1",
        "output": "869"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.O.O=C(O)COc1ccccc1.OCCO>>O=C(COc1ccccc1)OCCO",
        "output": "47"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[O-].CCOc1cc(C=O)ccc1O.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.Cc1ccccc1.[Br-].[K+]>>C=Cc1ccc(O)c(OCC)c1",
        "output": "649"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C(Cl)Cl.CO.CS(=O)(=NC(N)=O)c1ccc([C@@H](O)[C@H](N)CF)cc1.O=C(O)C(F)(F)F>>CS(=O)(=NC(N)=O)c1ccc([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)cc1",
        "output": "64"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CCCNc1nc(Nc2cccc(F)c2)ncc1C#CC(C)(C)CCO.Cc1ccccc1.O=C1NC(=O)c2ccccc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCNc1nc(Nc2cccc(F)c2)ncc1C#CC(C)(C)CCN1C(=O)c2ccccc2C1=O",
        "output": "420"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)N.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cn1nc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)c2ccc(Cl)cc21.F[B-](F)(F)F.O>>CC(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12",
        "output": "737"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrP(Br)Br.ClCCl.OCc1cccc(C2CCCC2)c1>>BrCc1cccc(C2CCCC2)c1",
        "output": "300"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCI.COc1cc2ncnc(N3CCC(n4c(=O)[nH]c5ccc([N+](=O)[O-])cc5c4=O)CC3)c2cc1OC>>CCn1c(=O)n(C2CCN(c3ncnc4cc(OC)c(OC)cc34)CC2)c(=O)c2cc([N+](=O)[O-])ccc21",
        "output": "326"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CCNC[C@@H]1NC(=O)OCc1ccccc1.CCN(CC)CC.CCOC(C)=O.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)OC(=O)N[C@@H]1CCN(C(=O)C(F)(F)F)C[C@@H]1NC(=O)OCc1ccccc1",
        "output": "397"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)C=O.Nc1ccc(-c2sc3ccccc3c2Cc2ccc(OCCN3CCCC3)cc2)cc1.O.O=C(O)CN1CCS(=O)(=O)CC1.On1nnc2cccnc21.[Cl-].[Na+]>>O=C(CN1CCS(=O)(=O)CC1)Nc1ccc(-c2sc3ccccc3c2Cc2ccc(OCCN3CCCC3)cc2)cc1",
        "output": "365"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(=O)(=O)c1ccc(-c2cn[nH]c(=O)c2Cc2ccc(F)cc2)cc1.Fc1ccc(Br)cc1F.Fc1ccccc1.N.O>>CS(=O)(=O)c1ccc(-c2cnn(-c3ccc(F)c(F)c3)c(=O)c2Cc2ccc(F)cc2)cc1",
        "output": "919"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)N=C=O.CCN(CC)CC.CCOC(C)=O.COc1cnc(-c2cc(Cl)ccc2F)nc1Nc1ccncc1C(=O)NCCCN>>COc1cnc(-c2cc(Cl)ccc2F)nc1Nc1ccncc1C(=O)NCCCNC(=O)NC(C)C",
        "output": "244"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc(N)cc(OC)c1.Cl.O=C([O-])O.[Na+].c1ccncc1>>COc1cc(N)cc(O)c1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(N)c1cccc([N+](=O)[O-])c1.ClCCl>>CC(NC(=O)OC(C)(C)C)c1cccc([N+](=O)[O-])c1",
        "output": "686"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClC(Cl)Cl.Nc1ccccc1NC(=O)OC(c1ccncc1)C1CCNCC1.O=C(Cl)c1ccc(Br)cc1.c1ccncc1>>O=C(Nc1ccccc1NC(=O)c1ccc(Br)cc1)OC(c1ccncc1)C1CCNCC1",
        "output": "11"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CC(=O)c2c(C(=O)O)coc2C1.Nc1ccc(F)cc1>>CC1CC(=O)c2c(C(=O)Nc3ccc(F)cc3)coc2C1",
        "output": "799"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNCC1.COc1cc2c(=O)[nH]cnc2cc1OCCCCl.[Na+].[OH-]>>COc1cc2c(=O)[nH]cnc2cc1OCCCN1CCCCC1",
        "output": "138"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCN1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.OCCOc1c(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)nc2c1cnn2-c1ccccc1>>Clc1ccc(-c2c(-c3ccc(Cl)cc3Cl)nc3c(cnn3-c3ccccc3)c2OCCN2CCOCC2)cc1",
        "output": "371"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCCNCC1.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccccn1.O.O=C(O)CC1CCCC1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCCN(C(=O)CC2CCCC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCN1.CCN=C=NCCCN(C)C.CCc1ccc2c(-c3cccc(C#N)c3)c(CCCCC(=O)O)c(C)nn12.CN(C)C=O.Cl.On1nnc2ccccc21>>CCc1ccc2c(-c3cccc(C#N)c3)c(CCCCC(=O)N3CCOCC3)c(C)nn12",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.COc1ccc(N2CC(NC(=O)OCc3ccccc3)CC2=O)cc1F.[Pd]>>COc1ccc(N2CC(N)CC2=O)cc1F",
        "output": "574"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.CN(C)C=O.ClCCCl.NCc1cc(C(F)(F)F)ccc1-n1cnnn1.On1nnc2cccnc21>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)NCc1cc(C(F)(F)F)ccc1-n1cnnn1",
        "output": "797"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1CNCCN1.O=Cc1ccc2cc(-c3csc(-c4ccncc4)n3)c(=O)[nH]c2c1>>CC1CN(Cc2ccc3cc(-c4csc(-c5ccncc5)n4)c(=O)[nH]c3c2)CCN1",
        "output": "567"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[O-].Cc1ccccc1.Cn1c(C2CC2)nc2ccc(-n3ccc(Cl)cc3=O)cc21.OCc1ccc(Br)o1.[K+]>>Cn1c(C2CC2)nc2ccc(-n3ccc(OCc4ccc(Br)o4)cc3=O)cc21",
        "output": "651"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CC[C@@H](NC(=O)N1C(=O)C(CC)(CC)[C@@H]1Oc1ccc(C(=O)COC)cc1)c1ccc(C)cc1.CO.[BH3-]C#N.[Cl-].[K+].[NH4+].[Na+].[OH-]>>C=CC[C@@H](NC(=O)N1C(=O)C(CC)(CC)[C@@H]1Oc1ccc(C(O)COC)cc1)c1ccc(C)cc1",
        "output": "24"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1cn2c(n1)sc1cccc(C)c12.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1cccc2sc3nc(CO)cn3c12",
        "output": "286"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)[C@@H]1C[C@H](O)CN1C(=O)OCc1ccccc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClC(Cl)Cl.ClCCl.c1ccncc1>>CCOC(=O)[C@@H]1C[C@H](OS(=O)(=O)c2ccc(C)cc2)CN1C(=O)OCc1ccccc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.Cc1ccccc1.Cc1ccccc1OCC(=O)Cl.Cc1ccccc1OCC(=O)N=C=S.Cc1ccccc1OCC(=O)O.O=S(Cl)Cl>>COc1cc2ncnc(Oc3ccc(NC(=S)NC(=O)COc4ccccc4C)cc3)c2cc1OC",
        "output": "961"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCCCCBr.CN(C)C=O.O=C([O-])[O-].Oc1ccc(-c2c3nc(c(-c4ccc(O)cc4)c4ccc([nH]4)c(-c4ccc(O)cc4)c4nc(c(-c5ccc(O)cc5)c5ccc2[nH]5)C=C4)C=C3)cc1.[K+].[K+]>>CCCCCCCCCOc1ccc(-c2c3nc(c(-c4ccc(O)cc4)c4ccc([nH]4)c(-c4ccc(O)cc4)c4nc(c(-c5ccc(O)cc5)c5ccc2[nH]5)C=C4)C=C3)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cn(-c2cccc(Br)c2)c2ncccc2c1=O.CO.Cl.O.[Na+].[OH-]>>O=C(O)c1cn(-c2cccc(Br)c2)c2ncccc2c1=O",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)Cn1nnc2cnc(N3CCC(Oc4cc(F)ccc4Br)CC3)nc21.CO.[Na+].[OH-]>>O=C(O)Cn1nnc2cnc(N3CCC(Oc4cc(F)ccc4Br)CC3)nc21",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NCC/C=C/c1cncnc1.CC(C)NC(C)C.CI.CN(C)C=O.COCCOC.O.[H-].[Na+]>>CN(CC/C=C/c1cncnc1)C(=O)OC(C)(C)C",
        "output": "803"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1c(-c2ccc(F)cc2)nn2cc(N(CCO)S(C)(=O)=O)c(-c3cccc(C(=O)O)c3)cc12.Cl.Cl.NC1(c2ccccn2)CC1>>COC(=O)c1c(-c2ccc(F)cc2)nn2cc(N(CCO)S(C)(=O)=O)c(-c3cccc(C(=O)NC4(c5ccccn5)CC4)c3)cc12",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC1CCC(c2ncc[nH]2)CC1.Cl>>NC1CCC(c2ncc[nH]2)CC1",
        "output": "538"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1ccc(N=C=O)cc1.Cc1ccccc1.OCc1cccs1>>CC(=O)c1ccc(NC(=O)OCc2cccs2)cc1",
        "output": "34"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(C)O.O=C1CCc2cc(Br)cc(F)c21.[BH3-]C#N.[NH4+].[Na+]>>NC1CCc2cc(Br)cc(F)c21",
        "output": "552"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(O)Cc1cc(O)cc(C(F)(F)F)c1.O=S(=O)(Cc1ccccn1)c1ccc(F)c(Cl)c1>>O=C(O)Cc1cc(Oc2ccc(S(=O)(=O)Cc3ccccn3)cc2Cl)cc(C(F)(F)F)c1",
        "output": "564"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)c1nc(-c2c(F)ccc(N)c2F)c(-c2ccnc(Cl)n2)s1.CC(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Cl)n2)s1.O=S(=O)(Cl)c1cccc(F)c1>>CC(C)(C)c1nc(-c2c(F)ccc(NS(=O)(=O)c3cccc(F)c3)c2F)c(-c2ccnc(Cl)n2)s1",
        "output": "68"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OCc1c(-c2cc(Nc3ccc(C4CCN(C(=O)OC(C)(C)C)CC4)cn3)c3nccn3c2)cccc1-n1ncc2cc(C(C)(C)C)cc(F)c2c1=O.ClCCl.O=C(O)C(F)(F)F>>CC(=O)OCc1c(-c2cc(Nc3ccc(C4CCNCC4)cn3)c3nccn3c2)cccc1-n1ncc2cc(C(C)(C)C)cc(F)c2c1=O",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOP(=O)(OCC)C(F)(F)c1cc2nc(C(=O)O)ccc2cc1Br.ClCCl.Nc1ccccc1>>CCOP(=O)(OCC)C(F)(F)c1cc2nc(C(=O)Nc3ccccc3)ccc2cc1Br",
        "output": "548"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1C(CO)C1c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.[Cl-].[NH4+]>>CC1C(C=O)C1c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CC(=O)Cl.CC(C)(C)c1cc(N)cc(C(C)(C)C)c1O.O=C([O-])[O-].[Na+].[Na+].c1ccccc1>>C=CC(=O)Nc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1",
        "output": "10"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOc1ccc([N+](=O)[O-])c(N2CCCCC2)c1.[Pd]>>CCOc1ccc(N)c(N2CCCCC2)c1",
        "output": "202"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C1CN(c2ccc(-n3cc(-c4ccc(Cl)cc4Cl)nc3Cc3ccc(Br)cc3)cc2)S(=O)(=O)N1.OB(O)c1ccc(Cl)nc1>>O=C1CN(c2ccc(-n3cc(-c4ccc(Cl)cc4Cl)nc3Cc3ccc(-c4ccc(Cl)nc4)cc3)cc2)S(=O)(=O)N1",
        "output": "899"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.O=c1c2occc2ccn1CCN(CCCO)S(=O)(=O)c1ccccc1[N+](=O)[O-]>>CS(=O)(=O)OCCCN(CCn1ccc2ccoc2c1=O)S(=O)(=O)c1ccccc1[N+](=O)[O-]",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COCOc1ccc(-c2noc(C3(CO)CC3)c2-c2ccccc2)cc1.ClCCl.O=C1OI(=O)(O)c2ccccc21>>COCOc1ccc(-c2noc(C3(C=O)CC3)c2-c2ccccc2)cc1",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.COc1ccc2c(c1)CCN(C1CCNCC1)C(=O)N2.Cc1cnc(Cl)cc1C(=O)c1cc(C)c2c(c1)oc(=O)n2C>>COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)c4cc(C)c5c(c4)oc(=O)n5C)c(C)cn3)CC1)C(=O)N2",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1cccc(Cc2c(-c3cccc(C(F)(F)F)c3)nn3cc(OC)ccc23)n1.Cl.[K+].[OH-]>>COc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3cccc(C(F)(F)F)c3)nn2c1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)NS(=O)(=O)c1ccc(-c2nccc(Nc3cc(C4CC4)[nH]n3)n2)s1.ClB(Cl)Cl.ClCCl.ClCCl.O>>NS(=O)(=O)c1ccc(-c2nccc(Nc3cc(C4CC4)[nH]n3)n2)s1",
        "output": "680"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.CN(C)C=O.CNCCCCCC(=O)OC.ClCCl.O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21>>COC(=O)CCCCCN(C)C(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cc1cc(C(=O)O)cc(C)c1O.Cl.O>>CCOC(=O)c1cc(C)c(O)c(C)c1",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NC1c2cccc(-c3cnc4ccccc4c3)c2-n2cccc21.O=C(O)c1ccnc2[nH]ccc12.On1nnc2ccccc21>>O=C(NC1c2cccc(-c3cnc4ccccc4c3)c2-n2cccc21)c1ccnc2[nH]ccc12",
        "output": "753"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1cc(-c2cnc(Nc3ccc(F)c(Cl)c3)nc2N2CCOCC2)ccn1.Cl.[Na+].[OH-]>>O=C(O)c1cc(-c2cnc(Nc3ccc(F)c(Cl)c3)nc2N2CCOCC2)ccn1",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(C(=O)Cl)cc1.ClCCOc1ccccc1.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(C(=O)c2ccc(OCCCl)cc2)cc1",
        "output": "61"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)[C@@H]1C[C@H]1c1nc(SCc2cccc(F)c2F)nc(O)c1C#N.Cl.O.[Na+].[OH-]>>N#Cc1c(O)nc(SCc2cccc(F)c2F)nc1[C@@H]1C[C@H]1C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COCCOc1cc(OC)cc2nc(-c3cc(C)c(OCc4ccccc4)c(C)c3)[nH]c(=O)c12.[Pd]>>COCCOc1cc(OC)cc2nc(-c3cc(C)c(O)c(C)c3)[nH]c(=O)c12",
        "output": "23"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N(C)C.O.O=C([O-])[O-].O=c1[nH]c2ccccc2n1C1CCN(C2CCC3CCc4cccc2c43)CC1.OCCCBr.[K+].[K+]>>O=c1n(CCCO)c2ccccc2n1C1CCN(C2CCC3CCc4cccc2c43)CC1",
        "output": "495"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COc1cc(C(C)=O)cc(S(F)(F)(F)(F)F)c1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.O.O=C([O-])O.[Br-].[Br-].[Br-].[Na+]>>COc1cc(C(=O)CBr)cc(S(F)(F)(F)(F)F)c1",
        "output": "360"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCOC(=O)C(C)(F)F.COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)[C@H](C)N)c1>>COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)[C@H](C)NC(=O)C(C)(F)F)c1",
        "output": "64"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCO.Cl.Clc1ccncc1.O=C1CN(S(=O)(=O)C2=Cc3ccc(Br)cc3OC2)CCN1NC1CCNCC1>>O=C1CN(S(=O)(=O)C2=Cc3ccc(Br)cc3OC2)CCN1NC1CCN(c2ccncc2)CC1",
        "output": "398"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1sc2cc(OC)ccc2c1C.[Na+].[OH-]>>COc1ccc2c(C)c(C(=O)O)sc2c1",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.CNCc1cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c2s1.O=C(CCl)c1cnccn1.O=C([O-])[O-].[Cs+].[Cs+]>>CN(CC(=O)c1cnccn1)Cc1cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c2s1",
        "output": "414"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)N1CCN(CC(=O)O)CC1.Nc1ccc2nc(NC3CCc4cc(F)ccc43)ccc2c1>>CC(C)N1CCN(CC(=O)Nc2ccc3nc(NC4CCc5cc(F)ccc54)ccc3c2)CC1",
        "output": "365"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C)c1ccccc1)C(C)(C)C)[C@H](CCC)C(=O)OC(C)(C)C.CC#N.CN(C)C=O.Cc1cc(Br)ccc1-c1ccccc1>>CCC[C@H](C(=O)OC(C)(C)C)[C@@H](C/C=C/c1ccc(-c2ccccc2)c(C)c1)C(=O)N[C@H](C(=O)N[C@H](C)c1ccccc1)C(C)(C)C",
        "output": "539"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2cccc(C(=O)O)c2)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cccc2[nH]c(-c3ccnc(Cl)c3)nc12.O>>CC(C)(C)OC(=O)N1CCC(c2cccc(C(=O)Nc3cccc4[nH]c(-c5ccnc(Cl)c5)nc34)c2)C1",
        "output": "759"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.C1CSCCN1.Clc1cc2ccccc2c(Cl)n1>>Clc1cc2ccccc2c(N2CCSCC2)n1",
        "output": "220"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)Oc2cc3nonc3cc2C(N)C1O.CCC(=O)Cl.CCN(CC)CC.ClCCl>>CCC(=O)NC1c2cc3nonc3cc2OC(C)(C)C1O",
        "output": "206"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)N=C=O.CCN(CC)CC.CCOC(C)=O.COc1cc(Nc2nc(N)c3scc(-c4cccc(N)c4)c3n2)cc(OC)c1OC>>COc1cc(Nc2nc(N)c3scc(-c4cccc(NC(=O)NC(C)C)c4)c3n2)cc(OC)c1OC",
        "output": "176"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#CC(C)(C)O.C1CCOC1.CC(C)NC(C)C.CN(C)C=O.NC1=N[C@@]2(CO1)c1cc(-c3cncnc3)ccc1Oc1ncc(Br)cc12.O.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CC(C)(O)C#Cc1cnc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncnc3)ccc1O2",
        "output": "719"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O[C@H]1C[C@H](n2ccc3c(N[C@H]4CCc5ccccc54)ncnc32)C[C@H]1COS(N)(=O)=O.CO.N>>NS(=O)(=O)OC[C@@H]1C[C@@H](n2ccc3c(N[C@H]4CCc5ccccc54)ncnc32)C[C@@H]1O",
        "output": "325"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2COc2ccc(-c3ccc(N)cc3)cc2)cc1.CS(=O)(=O)Cl>>COC(=O)c1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2COc2ccc(-c3ccc(NS(C)(=O)=O)cc3)cc2)cc1",
        "output": "194"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCOCCOCCOCCOCCO1.CC(C)(C)[O-].CN(C)CCO.COc1ccc(N(C)c2nc(Cl)nc3ccccc23)cc1.Cl.[K+]>>COc1ccc(N(C)c2nc(OCCN(C)C)nc3ccccc23)cc1",
        "output": "37"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.Nc1ccc2nc3ccccc3c(N)c2c1>>CC(=O)Nc1ccc2nc3ccccc3c(N)c2c1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O=C(O)c1cnc(OCC(F)(F)F)c(Cl)c1.O=S(=O)(O)O>>COC(=O)c1cnc(OCC(F)(F)F)c(Cl)c1",
        "output": "521"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCCCN.COCCCn1c(-c2ccc(C(C)(C)C)cc2)nc2ccc(OCCCCCC(=O)OC)cc21>>COCCCNC(=O)CCCCCOc1ccc2nc(-c3ccc(C(C)(C)C)cc3)n(CCCOC)c2c1",
        "output": "392"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(N)c1cccc(OC(F)(F)F)c1.COC(=O)c1ccc(C(=O)O)s1>>COC(=O)c1ccc(C(=O)NC(C)c2cccc(OC(F)(F)F)c2)s1",
        "output": "950"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CCN(CC)CC.CN(C)C=O.CN1CCOCC1.COC(=O)[C@@H](N)Cc1c[nH]cn1.Cl.Cl.ClC(Cl)Cl.O=C(O)C(CCCCc1ccccc1)Cc1cccc2ccccc12.O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O>>COC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C(CCCCc1ccccc1)Cc1cccc2ccccc12",
        "output": "129"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=COCCCCOc1cc(C=O)cc(OCCCCOC=C)c1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(C)=O.CNC.ClCCl.O=C([O-])O.[Na+].[Na+]>>C=COCCCCOc1cc(CN(C)C)cc(OCCCCOC=C)c1",
        "output": "567"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.CNC(=O)c1cc(Cl)ccn1.C[Si](C)(C)[N-][Si](C)(C)C.Cc1cc(Nc2ccc3cc(O)ccc3n2)ccc1Br.O=C([O-])[O-].[K+].[K+].[K+]>>CNC(=O)c1cc(Oc2ccc3nc(Nc4ccc(Br)c(C)c4)ccc3c2)ccn1",
        "output": "351"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)C(=O)Cl.COC(C)(C)CCO>>COC(C)(C)CCOC(=O)C(C)C",
        "output": "126"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COCOc1ccc(OC)cc1C(=O)c1ccc(O)cc1.Cc1oc(-c2ccccc2)nc1CCl.O.O=C([O-])[O-].[K+].[K+]>>COCOc1ccc(OC)cc1C(=O)c1ccc(OCc2nc(-c3ccccc3)oc2C)cc1",
        "output": "760"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN.CCO.CCOC(=O)C(C)Oc1cc([N+](=O)[O-])ccc1Cl>>CCNC(=O)C(C)Oc1cc([N+](=O)[O-])ccc1Cl",
        "output": "64"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cccc2cc(C(=O)O)c(=O)oc12.F[P-](F)(F)(F)(F)F.Nc1cccc(-c2cccc3[nH]ccc23)c1>>COc1cccc2cc(C(=O)Nc3cccc(-c4cccc5[nH]ccc45)c3)c(=O)oc12",
        "output": "799"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(/C(C#N)=C/c2ccc(O)cc2)cc1OC.O.O=C(Cl)N1CCC(N2CCCCC2)CC1.c1ccncc1>>COc1ccc(/C(C#N)=C/c2ccc(OC(=O)N3CCC(N4CCCCC4)CC3)cc2)cc1OC",
        "output": "425"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)Oc1cccc(OC(C)C)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cn1ncc2c1CNCC2.O.O=C([O-])[O-].OC(COc1cccc(Br)c1)CN1CCc2ccccc2C1.[Cs+].[Cs+]>>Cn1ncc2c1CN(c1cccc(OCC(O)CN3CCc4ccccc4C3)c1)CC2",
        "output": "294"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cccnc1Nc1ccc(Oc2ccnc3cc(C4CCN(C(=O)OC(C)(C)C)CC4)sc23)c(F)c1.Cl.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(c2cc3nccc(Oc4ccc(Nc5ncccc5C(=O)O)cc4F)c3s2)CC1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClC(Cl)Cl.O=c1[nH]c2ncc(Br)cc2n1CCN1CCNCC1>>CS(=O)(=O)N1CCN(CCn2c(=O)[nH]c3ncc(Br)cc32)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)C(Cc1c(F)cccc1F)N1CC(Oc2c(F)cccc2F)=CC1=O.Cl.O.O.[Li+].[OH-]>>O=C(O)C(Cc1c(F)cccc1F)N1CC(Oc2c(F)cccc2F)=CC1=O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)COC(=O)Cl.NC1CCN(CCC2CCOc3ccccc32)CC1.O=C(O)c1cccnc1>>O=C(NC1CCN(CCC2CCOc3ccccc32)CC1)c1cccnc1",
        "output": "674"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Brc1cccc(-c2nn3c(NC4CCCC4)cccc3c2-c2ccnc(NC3CCCC3)n2)c1.OB(O)c1ccncc1>>c1cc(-c2ccncc2)cc(-c2nn3c(NC4CCCC4)cccc3c2-c2ccnc(NC3CCCC3)n2)c1",
        "output": "904"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "B1C2CCCC1CCC2.C1CCOC1.C=CCn1ncc2cc(Br)ccc21.CCOCC.O.OO.[Na+].[OH-]>>OCCCn1ncc2cc(Br)ccc21",
        "output": "465"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(O)c1cc(-c2cccc(Cl)c2)on1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(OS(C)(=O)=O)c1cc(-c2cccc(Cl)c2)on1",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N(C)C.CC(=O)OC(C)=O.CCS(=O)(=O)N[C@H]1CCNC[C@H]1COc1ccc(C(C)C)cc1.Cl.O=C([O-])O.[Na+]>>CCS(=O)(=O)N[C@H]1CCN(C(C)=O)C[C@H]1COc1ccc(C(C)C)cc1",
        "output": "369"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "B.C1CCOC1.C1CCOC1.CCO.CCOC(C)=O.NC(C(=O)O)C(C(F)(F)F)C(F)(F)F.O>>NC(CO)C(C(F)(F)F)C(F)(F)F",
        "output": "231"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1ccccc1SCCC(=O)O.O=C(O)C(F)(F)F.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC(C)c1cccc2c1SCCC2=O",
        "output": "274"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1cccc2[nH]c(CO)nc12.O=[N+]([O-])c1cccc2[nH]c(Cl)nc12>>Nc1cccc2[nH]c(Cl)nc12",
        "output": "269"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(CCSc2ccc(N)cc2)CC1.CS(=O)(=O)Cl.c1ccncc1>>CC(C)(C)OC(=O)N1CCC(CCSc2ccc(NS(C)(=O)=O)cc2)CC1",
        "output": "194"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#Cc1cc(Nc2cc(Oc3ccc(N)c4ccccc34)ccn2)cc(C(=O)NCCOCCOCCOC)c1.C1CCOC1.CC(=O)OC(C)C.CCN(CC)CC.COc1c(CO)cc(C(C)(C)C)cc1NC(=O)Oc1ccccc1>>C#Cc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(CO)c4OC)c4ccccc34)ccn2)cc(C(=O)NCCOCCOCCOC)c1",
        "output": "965"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NCc1cccc(-c2cn(S(=O)(=O)c3ccccc3)c3nccc(Cl)c23)c1.CCOC(C)=O.Cl>>NCc1cccc(-c2cn(S(=O)(=O)c3ccccc3)c3nccc(Cl)c23)c1",
        "output": "793"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)c1c[nH]c2c(Br)cccc2c1=O.CI.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1cn(C)c2c(Br)cccc2c1=O",
        "output": "191"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OS(=O)(=O)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(C(C)C)C(C)C.Cl.Cl.ClCCl.O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCNC2)CC1.O=Cc1ccccc1.[Na+]>>O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCN(Cc3ccccc3)C2)CC1",
        "output": "567"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc(N(CC(=O)O)S(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1.OCCCNCc1ccccn1>>Cc1ccc(N(CC(=O)N(CCCO)Cc2ccccn2)S(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)Nc1ccc(Cl)cc1C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.FC(F)(F)c1cccc(CCNCc2ccc(C3CCCC3)cc2)c1.F[B-](F)(F)F.O>>CC(C)Nc1ccc(Cl)cc1C(=O)N(CCc1cccc(C(F)(F)F)c1)Cc1ccc(C2CCCC2)cc1",
        "output": "794"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "OCCCCCBr.Sc1cccc(Br)c1>>OCCCCCSc1cccc(Br)c1",
        "output": "124"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.CCN(C(C)C)C(C)C.Cc1ccccc1-n1nc(-c2c(-c3ccccc3)nn3c2CNCC3)ccc1=O.Cl.ClCCl>>CC(=O)N1CCn2nc(-c3ccccc3)c(-c3ccc(=O)n(-c4ccccc4C)n3)c2C1",
        "output": "369"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1cccc(Br)n1.COCCOC.ClCCl.Cl[Pd]Cl.O=C([O-])[O-].O=Cc1ccc(F)c(B(O)O)c1.[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COC(=O)c1cccc(-c2cc(C=O)ccc2F)n1",
        "output": "869"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.N#Cc1cccnc1Cl.O.[Na]>>COc1ncccc1C#N",
        "output": "433"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)C(Cc1ccc(O)cc1)Oc1ccccc1.CSc1ccc(CCO)cc1>>COC(=O)C(Cc1ccc(OCCc2ccc(SC)cc2)cc1)Oc1ccccc1",
        "output": "478"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.N#Cc1ccc(O)cc1.OCCC1CCN(c2cc(Cl)nnc2Cl)CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1ccc(OCCC2CCN(c3cc(Cl)nnc3Cl)CC2)cc1",
        "output": "478"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN.Cc1ccc(S(=O)(=O)OCC2Cc3cccc(-c4ccccc4F)c3O2)cc1>>CNCC1Cc2cccc(-c3ccccc3F)c2O1",
        "output": "853"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCc1cc(OC2CCCCO2)cc(O)c1C=O.ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCc1cc(OC2CCCCO2)cc(OS(=O)(=O)C(F)(F)F)c1C=O",
        "output": "731"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CCS(=O)(=O)N[C@H]1CCCc2c(-c3nnc(-c4ccc(OC(C)C)c(C#N)c4)s3)cccc21.CN.CO>>CNC(=O)CCS(=O)(=O)N[C@H]1CCCc2c(-c3nnc(-c4ccc(OC(C)C)c(C#N)c4)s3)cccc21",
        "output": "64"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CN(C)Cc1cc(-c2c(-c3ccc(F)cc3)nn3c(Cl)cccc23)nc(NC2CCCC2)n1.NC1CCCC1>>CN(C)Cc1cc(-c2c(-c3ccc(F)cc3)nn3c(NC4CCCC4)cccc23)nc(NC2CCCC2)n1",
        "output": "241"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "B.C1CCOC1.COc1ccc(Cc2ccc(C(=O)O)cc2)cc1.Cl>>COc1ccc(Cc2ccc(CO)cc2)cc1",
        "output": "72"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(=O)[O-].CC(C)(C)OC(=O)N1CCC(=O)CC1.CCO.CCOc1ncccc1[C@]1(NC(=O)N2CC3(CNC3)C2)C(=O)Nc2ccc(C#N)cc21.O=C(O)C(F)(F)F.O=C([O-])[O-].[B-]C#N.[K+].[K+].[Na+].[Na+]>>CCOc1ncccc1[C@]1(NC(=O)N2CC3(C2)CN(C2CCN(C(=O)OC(C)(C)C)CC2)C3)C(=O)Nc2ccc(C#N)cc21",
        "output": "187"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#Cc1cccnc1N.C1CCOC1.CCN(CC)CC.O.ON=C(Cl)Cc1ccc(OCc2ccccc2)cc1>>Nc1ncccc1-c1cc(Cc2ccc(OCc3ccccc3)cc2)no1",
        "output": "976"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCc1cc(I)ccc1Br.CN(C)C=O.O.[C-]#N.[K+]>>N#CCc1cc(I)ccc1Br",
        "output": "39"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cc1ccc(C(NC(=O)Cc2ccc([N+](=O)[O-])cc2)c2ccccc2)c(C)c1.[Cl-].[NH4+].[Zn]>>Cc1ccc(C(NC(=O)Cc2ccc(N)cc2)c2ccccc2)c(C)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C(O)C1CCCC1.O=C([O-])[O-].[K+].[K+]>>O=C(OCc1ccccc1)C1CCCC1",
        "output": "403"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COC(=O)C1(C)CCC(O[Si](C)(C)C(C)(C)C)CC1.[F-]>>COC(=O)C1(C)CCC(O)CC1",
        "output": "708"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C(=O)c1cc2cnc(Nc3ccc(CO)cn3)nc2n1C1CCCC1.CO.ClCCl.O=[Mn]=O>>CN(C)C(=O)c1cc2cnc(Nc3ccc(C=O)cn3)nc2n1C1CCCC1",
        "output": "520"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.O.O=[N+]([O-])O.Oc1ccc(Br)c(F)c1>>O=[N+]([O-])c1cc(Br)c(F)cc1O",
        "output": "21"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.C1COCCO1.CC(C)(C)OC(=O)N1CCc2[nH]nc(N3CCCC3)c2C1.Cl>>C1CCN(c2n[nH]c3c2CNCC3)C1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "NC(CO)c1cccnc1.O=C(O)c1nn(-c2ccc(F)cc2F)c2c1C[C@H]1C[C@@H]21>>O=C(NC(CO)c1cccnc1)c1nn(-c2ccc(F)cc2F)c2c1C[C@H]1C[C@@H]21",
        "output": "816"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cc(-c2ccccn2)c(=O)n(C2CCCC2)c1.O.O=S(=O)(O)O.[Li+].[OH-]>>O=C(O)c1cc(-c2ccccn2)c(=O)n(C2CCCC2)c1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.COC(=O)C1CCCN1C(c1ccccc1)(c1ccccc1)c1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCC1CCCN1C(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "430"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.O.O=[N+]([O-])c1cnc2cccnc2c1O.[Pt]>>Nc1cnc2cccnc2c1O",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Br.CC(=O)N(C)C1CCN(c2ccc(N)cc2)CC1.O.O=N[O-].[Na+].[Na+].[OH-]>>CC(=O)N(C)C1CCN(c2ccc(Br)cc2)CC1",
        "output": "373"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cccc(C)c1COc1cccc(C(=O)CCC(=O)O)c1.Cl.NN.O.OCCO.[K+].[OH-]>>Cc1cccc(C)c1COc1cccc(CCCC(=O)O)c1",
        "output": "92"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)c1ccncc1.COc1cc2nccc(Cl)c2cc1OC.Clc1ccccc1Cl.O.O=Cc1c(O)ccc2ccccc12>>COc1cc2nccc(Oc3ccc4ccccc4c3C=O)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCOc1nc(N)c2nc(OC)n(CCC3CCCCN3)c2n1.CCI.CCN(C(C)C)C(C)C.CO>>CCCCOc1nc(N)c2nc(OC)n(CCC3CCCCN3CC)c2n1",
        "output": "184"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=C1c2cnccc2CC(=O)c2ccccc21.CC(=O)[O-].CO.Cl.NO.[Na+]>>C=C1c2cnccc2CC(=NO)c2ccccc21",
        "output": "212"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)CS(=O)(=O)CC(C)(C)N1.CCCCBr.CCOCC>>CCCCN1C(C)(C)CS(=O)(=O)CC1(C)C",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Oc1ccc(-c2sc3cc(O)ccc3c2C(=O)c2ccc(OCCN3CCCCC3)cc2)cc1.CCN(CC)CC.ClCCl.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>CC(C)(C)[Si](C)(C)Oc1ccc(-c2sc3cc(OS(=O)(=O)C(F)(F)F)ccc3c2C(=O)c2ccc(OCCN3CCCCC3)cc2)cc1",
        "output": "843"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CNCCN1.CC(C)(C)OC(=O)NCC(=O)O.CCN(CC)CC.ClCCCl.ClCCl.On1nnc2ccccc21>>CC(C)(C)OC(=O)NCC(=O)N1CCNCC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.Cn1c2c(c3cc(C(=O)O)ccc31)CC(C1CCOCC1)CC2.F[P-](F)(F)(F)(F)F.O=C(CC1CNC1)NC1CC1>>Cn1c2c(c3cc(C(=O)N4CC(CC(=O)NC5CC5)C4)ccc31)CC(C1CCOCC1)CC2",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CC[Si](CC)(CC)OC(C1CCNCC1)C(F)(F)F.ClCCl.O=C(Cl)C1CC1.O=C([O-])O.[Na+]>>CC[Si](CC)(CC)OC(C1CCN(C(=O)C2CC2)CC1)C(F)(F)F",
        "output": "125"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.ClCCl.c1ccc(COCc2nnc(-c3ccccn3)s2)cc1>>OCc1nnc(-c2ccccn2)s1",
        "output": "178"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)c1nc(N2CCc3cccc(C(=O)/N=c4\\sc5ccccc5n4COCC[Si](C)(C)C)c3C2)ccc1CCC1OCCO1.Cl>>CC(C)(C)OC(=O)c1nc(N2CCc3cccc(C(=O)/N=c4\\sc5ccccc5n4COCC[Si](C)(C)C)c3C2)ccc1CCC=O",
        "output": "740"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(C(F)(F)F)c(Cl)c1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>FC(F)(F)c1ccc(CBr)cc1Cl",
        "output": "29"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccnc(F)c1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br.[W]>>Fc1cc(CBr)ccn1",
        "output": "29"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.FC(F)(F)c1c(Cl)ccnc1Cl.OCC1(c2ccccc2)CCCCC1.[H-].[Na+]>>FC(F)(F)c1c(OCC2(c3ccccc3)CCCCC2)ccnc1Cl",
        "output": "651"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1nc(-n2ccc(O)cc2=O)sc1C(=O)NCc1ccccc1.Cc1nc(CCl)cs1>>Cc1nc(COc2ccn(-c3nc(C)c(C(=O)NCc4ccccc4)s3)c(=O)c2)cs1",
        "output": "785"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)Oc1ccc(-c2nc(-c3cccc4c(CCC=O)c[nH]c34)no2)cc1Cl.[BH4-].[Na+]>>CC(C)Oc1ccc(-c2nc(-c3cccc4c(CCCO)c[nH]c34)no2)cc1Cl",
        "output": "223"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCCn1cnc2cc(-c3cc(C4CC4)cc(Cl)n3)ccc21.O=C(O)C(F)(F)F.[Na+].[OH-]>>NCCn1cnc2cc(-c3cc(C4CC4)cc(Cl)n3)ccc21",
        "output": "538"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.O.O=C(Cl)OCc1ccccc1.O=C([O-])[O-].OCC1CCCCNC1.[K+].[K+]>>O=C(OCc1ccccc1)N1CCCCC(CO)C1",
        "output": "427"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C(=O)Cl.CCN(C(C)C)C(C)C.COC(=O)c1ccc(CN)nc1.Cl.ClCCl>>COC(=O)c1ccc(CNC(=O)C(C)C)nc1",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)Cc1c(C(F)(F)F)nc(C)[nH]c1=O.CN(C)c1ccccc1.O=P(Cl)(Cl)Cl>>CCOC(=O)Cc1c(Cl)nc(C)nc1C(F)(F)F",
        "output": "14"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc2c(c1)Oc1cc(Br)ccc1C2.Nc1ccc2c(c1)Oc1cccc(Br)c1C2>>CC(C)(C)OC(=O)Nc1ccc2c(c1)Oc1cccc(Br)c1C2",
        "output": "735"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.ClCCCl.NCc1ccccc1.O=C(O)c1ccc2[nH]c3c(c2c1)CCCC3=O>>O=C(NCc1ccccc1)c1ccc2[nH]c3c(c2c1)CCCC3=O",
        "output": "753"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.Cc1nc2ccccc2[nH]1.ClCCCBr.ClCCl.[Br-].[Na+].[OH-]>>Cc1nc2ccccc2n1CCCCl",
        "output": "276"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc(B2OC(C)(C)C(C)(C)O2)c(F)cc1N.COc1cccc2c1cc(C(=O)O)n2C.ClCCl.F[P-](F)(F)(F)(F)F.c1ccncc1>>COc1cc(B2OC(C)(C)C(C)(C)O2)c(F)cc1NC(=O)c1cc2c(OC)cccc2n1C",
        "output": "548"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NCCOc1cccc(C(=O)N2CCC(CC3(C)SC(N[C@H]4CC5CCC4C5)=NC3=O)CC2)c1.CC1(CC2CCNCC2)SC(N[C@H]2CC3CCC2C3)=NC1=O>>CC1(CC2CCN(C(=O)c3cccc(OCCN)c3)CC2)SC(N[C@H]2CC3CCC2C3)=NC1=O",
        "output": "538"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCO.COC(=O)c1cncc(NC(=O)N2CCN(C(=O)c3cccc(OCCC4CCCCC4)c3)CC2)c1.O=C([O-])O.[BH4-].[Li+].[Na+]>>O=C(Nc1cncc(CO)c1)N1CCN(C(=O)c2cccc(OCCC3CCCCC3)c2)CC1",
        "output": "522"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.O=[Cr](=O)([O-])Cl.[O-][n+]1cccc2c(CO)ccc(OCc3ccccc3)c21.c1cc[nH+]cc1>>O=Cc1ccc(OCc2ccccc2)c2c1ccc[n+]2[O-]",
        "output": "179"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C[C@H](N)C(=O)OCc1ccccc1.CC(C)[C@@H](NC(=O)OC(C)(C)C)C(=O)O.CCN=C=NCCCN(C)C.CN1CCOCC1.Cc1ccc(S(=O)(=O)O)cc1.Cl.ClCCl.O.On1nnc2ccccc21>>CC(C)C[C@H](NC(=O)[C@H](NC(=O)OC(C)(C)C)C(C)C)C(=O)OCc1ccccc1",
        "output": "132"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCC(CC)(c1ccc(C#CC(OC(C)=O)C(C)(C(F)(F)F)C(F)(F)F)c(C)c1)c1ccc(O[Si](C)(C)C(C)(C)C)c(C)c1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.[F-]>>CCC(CC)(c1ccc(O)c(C)c1)c1ccc(C#CC(OC(C)=O)C(C)(C(F)(F)F)C(F)(F)F)c(C)c1",
        "output": "754"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)NCc1cn(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)nn1.[Li+].[OH-]>>O=C(N[C@@H](Cc1cscn1)C(=O)NCc1cn(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)nn1)[C@H]1O[C@@H]1C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(CCNc2c([N+](=O)[O-])c(C(F)(F)F)nc3ccccc23)CC1.CO.Cl[Ni]Cl.O.O.O.O.O.O.[BH4-].[Na+]>>CC(C)(C)OC(=O)N1CCC(CCNc2c(N)c(C(F)(F)F)nc3ccccc23)CC1",
        "output": "269"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12.COC(=O)C(C)(C)Cc1c(C(C)(C)C)c2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Cl)cc1>>CC(C)(Cc1c(C(C)(C)C)c2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Cl)cc1)C(=O)O",
        "output": "361"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C(=O)c1ccccc1N1CCC(NC(=O)C2(NC(=O)c3cc4ccccc4o3)CCCCC2)C(O)C1.CS(C)=O>>CN(C)C(=O)c1ccccc1N1CCC(NC(=O)C2(NC(=O)c3cc4ccccc4o3)CCCCC2)C(=O)C1",
        "output": "650"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCOc1ccc([N+](=O)[O-])cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1.CCO.[Pd]>>CCCOc1ccc(N)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1",
        "output": "202"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCO.Cc1c(C(N)=O)cccc1[N+](=O)[O-].[C].[Pd]>>Cc1c(N)cccc1C(N)=O",
        "output": "489"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CC1CCCN1c1nc(-c2ccc(F)c(Cl)c2)cc(N2CCNCC2)n1.CCN(C(C)C)C(C)C.CCOC(C)=O.Clc1ncc(Br)cn1>>CC1CCCN1c1nc(-c2ccc(F)c(Cl)c2)cc(N2CCN(c3ncc(Br)cn3)CC2)n1",
        "output": "36"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCCO.O=C(O)c1ccc2c(c1)-c1sc(-c3ncnn3-c3ccc(F)cc3F)cc1CCO2>>O=C(NCCO)c1ccc2c(c1)-c1sc(-c3ncnn3-c3ccc(F)cc3F)cc1CCO2",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C1CC=C(C)C1.CO.[Na+].[OH-]>>CC1=CCC(C(=O)O)C1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)c1cc(CN)n[nH]1.Cc1cc(N2CCN(CCOc3ccccc3)C2=O)sc1C(=O)O.Cc1cc(N2CCN(Cc3ccc(F)cc3)C2=O)sc1C(=O)O>>Cc1cc(N2CCN(Cc3ccc(F)cc3)C2=O)sc1C(=O)NCc1cc(C(C)(C)C)[nH]n1",
        "output": "736"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCN(CCC)C1CCc2cccc(C(=O)OC)c2C1.CO.Cl.O.[Na+].[OH-]>>CCCN(CCC)C1CCc2cccc(C(=O)O)c2C1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.COc1cc(Nc2ncc(C(C)N)nn2)cc(OC)c1OC.ClCCl.O=C(Cl)c1ccccc1[N+](=O)[O-]>>COc1cc(Nc2ncc(C(C)NC(=O)c3ccccc3[N+](=O)[O-])nn2)cc(OC)c1OC",
        "output": "271"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCO.CCOC(=O)CCc1cc(OCc2ccc3ccccc3n2)nn1C(C)C.Cc1ccccc1.[Cl-].[H-].[NH4+]>>CC(C)n1nc(OCc2ccc3ccccc3n2)cc1CCCO",
        "output": "225"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccccc1.FC(F)(F)c1cccc(CBr)c1.OC1CCC2(CC1)OCCO2.[H-].[Na+]>>FC(F)(F)c1cccc(COC2CCC3(CC2)OCCO3)c1",
        "output": "464"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.Cl.ClCCCBr.FC(F)(F)c1cccc(N2CCNCC2)c1.O.[Na+].[OH-]>>FC(F)(F)c1cccc(N2CCN(CCCCl)CC2)c1",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.CCCOc1nc(CN2CCOCC2)nc2oc(-c3cccc(OC)c3)nc12.ClCCl.O=C([O-])O.[Na+]>>CCCOc1nc(CN2CCOCC2)nc2oc(-c3cccc(O)c3)nc12",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NCCNc1c(-c2ccoc2)ccc(CS(=O)(=O)c2ccccc2)c1C(=O)O.COC(=O)c1c(CS(=O)(=O)c2ccccc2)ccc(-c2ccoc2)c1N>>Nc1c(-c2ccoc2)ccc(CS(=O)(=O)c2ccccc2)c1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.ClCCl.OCCCN1CCOCC1>>CS(=O)(=O)OCCCN1CCOCC1",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN(c1nc(Nc2cnn(C)c2)ncc1Cl)C1CCC2(CC1)CCN(C(=O)OC(C)(C)C)CC2.CO.Cl.ClCCl.ClCCl.O.O=C([O-])O.[Na+]>>CN(c1nc(Nc2cnn(C)c2)ncc1Cl)C1CCC2(CCNCC2)CC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNC1.C1COCCO1.CCO.O=C([O-])[O-].O=C1Nc2cccnc2N(C(=O)CCCCl)c2ccccc21.[Na+].[Na+]>>O=C1Nc2cccnc2N(C(=O)CCCN2CCCC2)c2ccccc21",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)CCCCCCCl.CCCC[N+](CCCC)(CCCC)CCCC.CN1CCCC1=O.CO.COC(=O)C=Cc1ccc(O)cc1.C[O-].[Cl-].[Na+]>>COC(=O)C=Cc1ccc(OCCCCCCC(C)C)cc1",
        "output": "74"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)c1ccc(-c2nc(CS(=O)(=O)C3CCCCC3)c(C)o2)cc1.Cl.O>>Cc1oc(-c2ccc(C(=O)O)cc2)nc1CS(=O)(=O)C1CCCCC1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)N(C)C.CCc1cc(C(=O)O)n(C)n1.CN(C)C=O.Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)ccc1F.O=C(Cl)C(=O)Cl>>CCc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1",
        "output": "844"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1CCN(C(=O)c2ccc3c(c2)c2c(n3S(=O)(=O)c3cn(C)cn3)CCNC2)CC1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C1CCOCC1>>CC1CCN(C(=O)c2ccc3c(c2)c2c(n3S(=O)(=O)c3cn(C)cn3)CCN(C3CCOCC3)C2)CC1",
        "output": "187"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCNc1c(F)cc(F)c2oc(-c3ccc(NCCCN4C(=O)c5ccccc5C4=O)c(F)c3)cc(=O)c12.CN(C)C=O.CO.NN.O>>CCCCCCNc1c(F)cc(F)c2oc(-c3ccc(NCCCN)c(F)c3)cc(=O)c12",
        "output": "242"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.Cc1n[nH]c(C)c1Oc1ccc(Cl)cc1.Cl.NCCCl.O.O=S(=O)([O-])O.[Na+].[OH-]>>Cc1nn(CCN)c(C)c1Oc1ccc(Cl)cc1",
        "output": "604"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cl.ClCCl.O=S(=O)(c1ccccc1)n1cc(-c2cnn(C3CCNCC3)c2)c2ccc(F)cc21>>CS(=O)(=O)N1CCC(n2cc(-c3cn(S(=O)(=O)c4ccccc4)c4cc(F)ccc34)cn2)CC1",
        "output": "584"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)N1CCC(N)CC1.O=C(O)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1>>CCOC(=O)N1CCC(NC(=O)c2ccc(-c3cnc4c(c3)N(Cc3cc(Cl)ccc3C(F)(F)F)CCN4)cc2)CC1",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CC(O)C1.CCN(CC)CC.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)N1CC(OS(C)(=O)=O)C1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.ClCCCl.NCCCCNC(=O)C(c1ccccc1)c1ccccc1.O=C(O)C=Cc1cccnc1.On1nnc2ccccc21>>O=C(C=Cc1cccnc1)NCCCCNC(=O)C(c1ccccc1)c1ccccc1",
        "output": "549"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)c1cc(F)c(C)c(-n2ccnc(NC(C)(C)c3ccccc3OCCCl)c2=O)c1.Cl.O.O.[Li+].[OH-]>>Cc1c(F)cc(C(=O)O)cc1-n1ccnc(NC(C)(C)c2ccccc2OCCCl)c1=O",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CN(C)C=O.O=C(Cl)C(=O)Cl.O=C(O)c1cc(F)c(F)cc1Cl>>O=C(Cl)c1cc(F)c(F)cc1Cl",
        "output": "448"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCC.CO.Cc1cc(OC(F)(F)F)ccc1-c1ccn(-c2ccc3c4c(oc3c2)CCN(C(=O)OC(C)(C)C)C4)c(=O)c1.Cl>>Cc1cc(OC(F)(F)F)ccc1-c1ccn(-c2ccc3c4c(oc3c2)CCNC4)c(=O)c1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.O.O=Cc1cc(I)ccc1F.[BH4-].[Na+]>>OCc1cc(I)ccc1F",
        "output": "356"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC[N+](CCC)(CCC)CCC.CCOC(=O)c1nc2ccccn2c1CO.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-]>>CCOC(=O)c1nc2ccccn2c1C=O",
        "output": "287"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCc1cn([C@H]2C[C@H](O)[C@@H](CNC)O2)c(=O)[nH]c1=O.CO.ClCCl.O=C(Cl)Cc1ccccc1Br.O=S(Cl)Cl.c1ccccc1.c1ccncc1>>CCc1cn([C@H]2C[C@H](O)[C@@H](CN(C)C(=O)Cc3ccccc3Br)O2)c(=O)[nH]c1=O",
        "output": "125"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.O.OCCCCCCCC(F)(F)C(F)(F)F.c1ccncc1>>Cc1ccc(S(=O)(=O)OCCCCCCCC(F)(F)C(F)(F)F)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CCN(CC)CC.CNCCC(O)c1ccccc1.ClCCl.O>>CC(=O)N(C)CCC(O)c1ccccc1",
        "output": "125"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.Fc1ccc(C2CCNCC2)cc1.O=C([O-])O.O=C[C@@H]1CN(Cc2ccccc2)C[C@H]1c1ccsc1.[Na+].[Na+]>>Fc1ccc(C2CCN(C[C@@H]3CN(Cc4ccccc4)C[C@H]3c3ccsc3)CC2)cc1",
        "output": "484"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Oc1ccc2c(c1)OCC21CCN(Cc2ccccc2)CC1.[OH-].[OH-].[Pd+2]>>Oc1ccc2c(c1)OCC21CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CC(=O)c1ccc([N+](=O)[O-])cc1.CC(C)=O.CCN(CC)CCC(=O)c1ccc([N+](=O)[O-])cc1.CCNCC.CCO.Cl.Cl.[Pd]>>CCN(CC)CCCc1ccc([N+](=O)[O-])cc1",
        "output": "92"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CNOC.Cc1ncc(C2(C(=O)O)CCC(F)(F)CC2)cn1.Cl.Cl.O.On1nnc2ccccc21>>CON(C)C(=O)C1(c2cnc(C)nc2)CCC(F)(F)CC1",
        "output": "54"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN(C)c1cc(C2OCCO2)ccc1O.Cl.O=C([O-])O.[Na+]>>CN(C)c1cc(C=O)ccc1O",
        "output": "655"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCOC(=O)c1cn(C2CC2)c2c(OC(C)C)c(F)c(F)c([N+](=O)[O-])c2c1=O.O.[Fe]>>CCOC(=O)c1cn(C2CC2)c2c(OC(C)C)c(F)c(F)c(N)c2c1=O",
        "output": "202"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.COc1ccc(C#N)c(F)c1O.c1ccncc1>>COc1ccc(C#N)c(F)c1OC(C)=O",
        "output": "46"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COC(=O)C1c2nc(SC)ncc2C(C)(C)N1C(=O)OCc1ccccc1.O=S([O-])OO.[K+]>>COC(=O)C1c2nc(S(C)(=O)=O)ncc2C(C)(C)N1C(=O)OCc1ccccc1",
        "output": "840"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NCC1CCCO1.O=C(O)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1>>O=C(NCC1CCCO1)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)C2CC[C@@]1(CS(=O)(=O)O)C(=O)C2.CCCCCC.CCO.CCOCC.CN1CC(N2CCC(N(C)C(=O)Nc3cc(Oc4ccc(N)cc4F)ncn3)CC2)C1.Cc1ccccc1.O=C(Cc1ccc(F)cc1)N=C=S>>CN1CC(N2CCC(N(C)C(=O)Nc3cc(Oc4ccc(NC(=S)NC(=O)Cc5ccc(F)cc5)cc4F)ncn3)CC2)C1",
        "output": "961"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCOC(Cc1ccc(OCc2ccccc2)cc1)C(=O)OC.CCOC(C)=O>>CCCCCCOC(Cc1ccc(O)cc1)C(=O)OC",
        "output": "23"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Nc1cccc(S(N)(=O)=O)c1.O=C(O)c1cnn2c(C(F)(F)F)cc(-c3ccc(C(F)(F)F)c(Cl)c3)nc12>>NS(=O)(=O)c1cccc(NC(=O)c2cnn3c(C(F)(F)F)cc(-c4ccc(C(F)(F)F)c(Cl)c4)nc23)c1",
        "output": "969"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1csc(-c2ccco2)n1.CO.[K+].[OH-]>>O=C(O)c1csc(-c2ccco2)n1",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCNCCO.CS(=O)(=O)Cl.ClCCl.O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4cc(CO)ccc4c23)cc1)c1ccccc1>>CCN(CCO)Cc1ccc2c(c1)c(=O)[nH]c1nccc(Nc3ccc(NC(=O)c4ccccc4)cc3)c12",
        "output": "765"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1=C(c2ccccc2)C(=O)N(C(C)(C)C(=O)O)CO1.CCN(CC)CC.ClC(Cl)(Cl)Cl.ClCCl.Nc1cccc(Cl)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC1=C(c2ccccc2)C(=O)N(C(C)(C)C(=O)Nc2cccc(Cl)c2)CO1",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=Cc1cccc(-c2ccc3sccc3c2)c1.[BH4-].[Na+]>>OCc1cccc(-c2ccc3sccc3c2)c1",
        "output": "356"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(=O)[O-].Cl.NO.O=Cc1cc2c(cc1Br)OCO2.[Na+]>>N#Cc1cc2c(cc1Br)OCO2",
        "output": "453"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)CCNC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C.N>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)NCCC(N)=O",
        "output": "432"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Cc1cc(-c2cn3cccc(C)c3n2)ccc1O.ClCCCBr.[H-].[Na+]>>Cc1cc(-c2cn3cccc(C)c3n2)ccc1OCCCCl",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.COC(=O)c1cccc(C#N)c1C.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COC(=O)c1cccc(C#N)c1CBr",
        "output": "545"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Cl)n3)c3cccnc23)n(-c2cccc(CP(C)(C)=O)c2)n1.CCOC(C)=O.CN(C)C=O.COc1cc(N)cc(OCCN2CCOCC2)c1>>COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)C)nn4-c4cccc(CP(C)(C)=O)c4)c4ncccc34)n2)cc(OCCN2CCOCC2)c1",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)N1CCC(=O)CC1.CN(C)C=O.COc1cccc(C(=O)N[C@@H]2CCCNC2)c1.[N-]=C=O>>CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3cccc(OC)c3)C2)CC1",
        "output": "187"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNC1.C1CCOC1.COc1ccc2c(C(=O)c3ccc(OCCCl)cc3)c(C3CCCCC3)sc2c1.O.[H-].[Na+]>>COc1ccc2c(C(=O)c3ccc(OCCN4CCCC4)cc3)c(C3CCCCC3)sc2c1",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.NCc1ccccn1.O=C=NCCCc1ccccc1.c1ccccc1>>O=C(NCCCc1ccccc1)NCc1ccccn1",
        "output": "244"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)C(C)(C)Sc1ccc(C(=O)O)cc1.CN(C)c1ccncc1.ClCCl.OCc1cn(Cc2ccc(C(F)(F)F)cc2)nn1>>CC(C)(C)OC(=O)C(C)(C)Sc1ccc(C(=O)OCc2cn(Cc3ccc(C(F)(F)F)cc3)nn2)cc1",
        "output": "33"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCO.Cc1cc(O)nc(S)n1.Clc1ccc(Br)cc1CBr>>Cc1cc(O)nc(SCc2cc(Br)ccc2Cl)n1",
        "output": "699"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCNCC3(C)C)n(C)c2n1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.C[C@@H](O)C(=O)O.ClCCl.F[P-](F)(F)(F)(F)F>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCN(C(=O)[C@@H](C)O)CC3(C)C)n(C)c2n1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCC(C(=O)OC)c1c(C)nc(Cl)nc1-c1ccc(C)cc1.CCN(CC)CC.CCN1CCCNCC1.O=C([O-])O.[Na+]>>CCCC(C(=O)OC)c1c(C)nc(N2CCCN(CC)CC2)nc1-c1ccc(C)cc1",
        "output": "36"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.O=C(O)CC(CC(=O)O)c1ccc2c(c1)OCO2>>O=C1CC(c2ccc3c(c2)OCO3)CC(=O)O1",
        "output": "436"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1ccc(N)cc1.O=C(O)CC1CCc2cc(Br)cc3[nH]c(=O)c(=O)n1c23>>CC(=O)c1ccc(NC(=O)CC2CCc3cc(Br)cc4[nH]c(=O)c(=O)n2c34)cc1",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C#N)c1cccc(C(=O)Nc2cccc([N+](=O)[O-])c2)c1.CCO.[C].[Pd]>>CC(C)(C#N)c1cccc(C(=O)Nc2cccc(N)c2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Clc1ncnc(Cl)n1.Nc1cc(F)c(N2CCN(C3COC3)CC2)c(F)c1.O>>Fc1cc(Nc2ncnc(Cl)n2)cc(F)c1N1CCN(C2COC2)CC1",
        "output": "592"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)OCC(=O)N1CCC(c2nc(-c3ccc4nnc(C(C)C)n4n3)c(-c3ccc(F)cc3F)[nH]2)CC1.Cl.[Na+].[OH-]>>CC(C)c1nnc2ccc(-c3nc(C4CCN(C(=O)CO)CC4)[nH]c3-c3ccc(F)cc3F)nn12",
        "output": "687"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CNCCO.Cc1cccc2c1C(Nc1cc(C(=O)O)cn3c(C)c(C)nc13)CCO2.Cl.ClCCl.O.On1nnc2ccccc21>>Cc1cccc2c1C(Nc1cc(C(=O)N(C)CCO)cn3c(C)c(C)nc13)CCO2",
        "output": "256"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.Cn1c(COc2ccc(C#N)cc2)nc2nc(CO)ccc21.[Mn+4].[O-2].[O-2]>>Cn1c(COc2ccc(C#N)cc2)nc2nc(C=O)ccc21",
        "output": "263"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=C1Nc2cccnc2N(C(=O)CCNCc2ccccc2)c2ccccc21.[Pd]>>NCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21",
        "output": "561"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCCCCCCCCCCCCCCNc1ccc(CCC(=O)O)cc1.O=C(n1ccnc1)n1ccnc1.Oc1ccccc1.[H-].[Na+]>>CCCCCCCCCCCCCCCCNc1ccc(CCC(=O)Oc2ccccc2)cc1",
        "output": "108"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.Nc1cc(N)cc(C(F)(F)F)c1.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>Nc1cc(NC(=O)C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "106"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)c1cnn(C(=O)OC(C)(C)C)c1.CCOCC.CO.Cc1ccccc1.O.O.O.O.O=C([O-])C(O)C(O)C(=O)[O-].[H-].[K+].[Na+]>>CC(C)(C)OC(=O)n1cc(CO)cn1",
        "output": "471"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=C1CC[C@H]2[C@H](CN)[C@@H]([C@@]3(C)CC[C@H](O)C[C@@H]3CO)CC[C@]12C.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Cc1ccccc1C(=O)O.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>C=C1CC[C@H]2[C@H](CNC(=O)c3ccccc3C)[C@@H]([C@@]3(C)CC[C@H](O)C[C@@H]3CO)CC[C@]12C",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1=COCCC1.C1CCOC1.CCOCC.C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)[C@@H]5C[C@@H]5[C@@]43C)[C@@H]1CC[C@@H]2O.O=P(Cl)(Cl)Cl>>C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)[C@@H]5C[C@@H]5[C@@]43C)[C@@H]1CC[C@@H]2OC1CCCCO1",
        "output": "306"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)CN(C(=O)OC(C)(C)C)c1cccc(CN)n1.O=S(=O)(Cl)c1cccs1>>CC(C)(C)OC(=O)CN(C(=O)OC(C)(C)C)c1cccc(CNS(=O)(=O)c2cccs2)n1",
        "output": "600"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(C)=O.Cl.O.O=C(O)c1ccc(Cl)nc1.OCC(F)F.[K+].[OH-]>>O=C(O)c1ccc(OCC(F)F)nc1",
        "output": "433"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(C(C)C)C(C)C.COc1ccc(-c2cc(CCC=O)nn2C(C)(C)C)cc1.COc1ccc(N2CCNCC2)cc1.[Na+]>>COc1ccc(-c2cc(CCCN3CCN(c4ccc(OC)cc4)CC3)nn2C(C)(C)C)cc1",
        "output": "484"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc2c(-c3cccc(F)c3)cc(=O)oc2c1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>O=c1cc(-c2cccc(F)c2)c2ccc(CBr)cc2o1",
        "output": "29"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCC.CCOC(C)=O.Cc1c(C)c2c(c(C)c1OCc1ccccc1)CCC(C)(CCOC(=O)C(C)c1ccc(-c3ccccc3)c(F)c1)O2.[Pd]>>Cc1c(C)c2c(c(C)c1O)CCC(C)(CCOC(=O)C(C)c1ccc(-c3ccccc3)c(F)c1)O2",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(SCCCCOc2cc3c(cc2[N+](=O)[O-])NC(=O)OC3(C)C)cc1OC.OO>>COc1ccc(S(=O)CCCCOc2cc3c(cc2[N+](=O)[O-])NC(=O)OC3(C)C)cc1OC",
        "output": "199"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C[O-].Cc1ccccc1.OC(c1cccnc1)(c1cccc(F)c1)c1ccc2nc(Cl)c(Cc3ccc(-n4cccn4)cc3)c(Cl)c2c1.[Na+]>>COc1nc2ccc(C(O)(c3cccnc3)c3cccc(F)c3)cc2c(Cl)c1Cc1ccc(-n2cccn2)cc1",
        "output": "433"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1ccc2c(Nc3cc(N)ccc3Sc3ccc(NC(=O)OC(C)(C)C)cc3)ncnc2n1.CC(C)c1ccc2c(Nc3cccc(C(=O)O)c3)ncnc2n1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CS(C)=O.F[P-](F)(F)(F)(F)F.O>>CC(C)c1ccc2c(Nc3cccc(C(=O)Nc4ccc(Sc5ccc(NC(=O)OC(C)(C)C)cc5)c(Nc5ncnc6nc(C(C)C)ccc56)c4)c3)ncnc2n1",
        "output": "50"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)[C@@H](Cc1cc(C)c2[nH]c(OC)nc2c1)OC(=O)N1CCC(N2CCc3ccccc3NC2=O)CC1.Cl.O.[Li+].[OH-]>>COc1nc2cc(C[C@@H](OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)O)cc(C)c2[nH]1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C[C@H]2NC(=O)n3c2nc2ccccc23)cc1.NCCCO.O=C(O)C(F)(F)F>>COc1ccc(C[C@@H](NC(=O)NCCCO)c2nc3ccccc3[nH]2)cc1",
        "output": "999"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.CCOC(C)=O.COC(=O)Cc1ccccc1O.Cc1ccccc1.Cc1oc(-c2ccccc2)nc1CCc1ccc(CO)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)Cc1ccccc1OCc1ccc(CCc2nc(-c3ccccc3)oc2C)cc1",
        "output": "347"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N[C@@H]1CCC[C@H](C(=O)O)C1.CCOC(=O)Cl.[NH4+].[OH-]>>CC(C)(C)OC(=O)N[C@H]1CCC[C@@H](C(N)=O)C1",
        "output": "313"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(C#CCN2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](Cc3c[nH]c4ccccc34)C2)cn1.CCOC(C)=O.Cl.ClCCl.O=C(O)C(F)(F)F>>Nc1ccc(C#CCN2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](Cc3c[nH]c4ccccc34)C2)cn1",
        "output": "885"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(O)CO.CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2CCC(=O)CC2)c2ncnn12.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2CCC3(CC2)OCC(C)(C)O3)c2ncnn12",
        "output": "265"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccc(N)cc1-c1ccc(C(=O)NCC2CC2)cc1.O=C(O)C1CCOCC1>>Cc1ccc(NC(=O)C2CCOCC2)cc1-c1ccc(C(=O)NCC2CC2)cc1",
        "output": "365"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.Cn1cc([N+](=O)[O-])c(N2C[C@@H](O[Si](C)(C)C(C)(C)C)CC2=O)n1.[C].[Pd]>>Cn1cc(N)c(N2C[C@@H](O[Si](C)(C)C(C)(C)C)CC2=O)n1",
        "output": "628"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cl.O=C(Nc1nc2ccc(Oc3cccc([N+](=O)[O-])c3)cc2s1)C1CC1.[Fe]>>Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)sc3c2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1[nH]nc(Nc2ccnc3ccc(S(=O)(=O)C(C)(C)C)cc23)c1C.O=S(=O)(O)O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1c(Nc2ccnc3ccc(S(=O)(=O)C(C)(C)C)cc23)n[nH]c1CO",
        "output": "391"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.Cl.O.O=C(O)CCSCCC(=O)O.O=S([O-])OO.[K+]>>O=C(O)CCS(=O)(=O)CCC(=O)O",
        "output": "847"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.CC(Cl)Cl.Nc1ccccc1Oc1ccccc1.[Na+]>>CC(C)Nc1ccccc1Oc1ccccc1",
        "output": "469"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1c([C@H]2CN3CC[NH2+]C[C@H]3CO2)ccc(F)c1C#N.F[P-](F)(F)(F)(F)F.O=C(O)Cc1cnc(-n2cnnn2)nc1.O=C([O-])C(F)(F)F>>Cc1c([C@H]2CN3CCN(C(=O)Cc4cnc(-n5cnnn5)nc4)C[C@H]3CO2)ccc(F)c1C#N",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.CCN(CC)CC.ClCCl.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>O=[N+]([O-])c1ccccc1S(=O)(=O)N1CCOCC1",
        "output": "99"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)CC(O)CCN1Cc1ccccc1.CN(C)C=O.Clc1cccc(Cl)n1.[H-].[Na+]>>CC1(C)CC(Oc2cccc(Cl)n2)CCN1Cc1ccccc1",
        "output": "433"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)COc1ccc(OCc2ccc(F)cc2)cc1.CN.O>>CNC(=O)COc1ccc(OCc2ccc(F)cc2)cc1",
        "output": "64"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1cc2ccncc2cc1-c1cccnc1.C[S-].[Na+]>>Oc1cc2ccncc2cc1-c1cccnc1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc2ncnc(Cl)c2cc1OC.c1cc2c(cc1C1CNCCN1)OCO2>>COc1cc2ncnc(N3CCNC(c4ccc5c(c4)OCO5)C3)c2cc1OC",
        "output": "296"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)c1cn(CCCC#N)c(=O)cc1Nc1ccc(I)cc1F.[Na+].[OH-]>>N#CCCCn1cc(C(=O)O)c(Nc2ccc(I)cc2F)cc1=O",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC(C(=O)OC)c1c(C)nc2sc3c(c2c1-c1ccc(OC)c(OC)c1)CCCC3.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc2sc3c(c2c1-c1ccc(OC)c(OC)c1)CCCC3",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(O)cc1F.[Na+].[Na+]>>O=[N+]([O-])c1ccc(OCc2ccccc2)cc1F",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1ccc(C2=NOC(CCC=O)C2)cc1OC.ClCCl.[Na+].c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>COc1ccc(C2=NOC(CCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)C2)cc1OC",
        "output": "484"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)[C@H]1CC[C@@H](N)CC1.CCN(CC)CC.ClCCl.O=S(=O)(Cl)c1ccc2c(Cl)cnc(Cl)c2c1>>CC(C)(C)OC(=O)[C@H]1CC[C@@H](NS(=O)(=O)c2ccc3c(Cl)cnc(Cl)c3c2)CC1",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C(CC(=O)OC(C)(C)C)(Cc1cc(Cl)c(N)c(C(F)(F)F)c1)C(=O)OCC.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)C(CC(=O)O)(Cc1cc(Cl)c(N)c(C(F)(F)F)c1)C(=O)OCC",
        "output": "278"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)C(=O)Nc2cc(Br)ccc21.CC1(C)OB(c2cnccc2F)OC1(C)C>>CC1(C)C(=O)Nc2cc(-c3cnccc3F)ccc21",
        "output": "954"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CNCCN1.CN1CCCC1=O.ClCCl.N#Cc1cc(F)ccc1F>>N#Cc1cc(F)ccc1N1CCNCC1",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(C(=O)CC(c2ccc(C#CCO)cc2)c2ccccc2C)ccn1.Cl.NO.O=C([O-])O.[Na+]>>Cc1cc(C(CC(c2ccc(C#CCO)cc2)c2ccccc2C)=NO)ccn1",
        "output": "212"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1nc(-c2ccccc2)c(-c2ccc(Cl)nc2)o1.ClCCl.Clc1ccccn1.NN>>Cc1nc(-c2ccccc2)c(-c2ccc(NN)nc2)o1",
        "output": "417"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(NC(=O)c1ccc2cncc(Br)c2n1)c1ccc(S(C)(=O)=O)cc1.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccc(F)cc1F.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(NC(=O)c1ccc2cncc(-c3ccc(F)cc3F)c2n1)c1ccc(S(C)(=O)=O)cc1",
        "output": "871"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCC/C=C/CCCCCCCC(=O)Cl.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12.CO.ClCCl>>CCCCCCCC/C=C/CCCCCCCC(=O)OCCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12",
        "output": "126"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])c(F)c2)CC1.CCOC(C)=O.[H][H].[Pd]>>CC(C)(C)OC(=O)N1CCN(c2ccc(N)c(F)c2)CC1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1cc(C(F)(F)F)c(CO)cc1N.Nc1c(Br)cc(C(F)(F)F)cc1C(=O)O>>Nc1cc(CO)c(C(F)(F)F)cc1C(=O)O",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1cccc(N2CCC(N3CCOCC3)CC2)c1.C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.ClCCl.Cl[Pd]Cl.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2cccc(N3CCC(N4CCOCC4)CC3)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[O-].CC(C)O.O=C(O)c1ccc(Cl)nc1Cl.[K+]>>CC(C)Oc1ccc(C(=O)O)c(Cl)n1",
        "output": "433"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1ccc(N)cc1O.O=S(=O)(O)O.[NH4+].[OH-]>>NC(=O)c1ccc(N)cc1O",
        "output": "67"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)CC(=O)Cl.CCCCC(=O)Cl.COc1ccc(N2CCNCC2)cc1.Cl.Cl.Fc1cc(N2CCNCC2)ccc1OCc1ccccc1>>CCCCC(=O)N1CCN(c2ccc(OCc3ccccc3)c(F)c2)CC1",
        "output": "125"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)COB(c2ccc(C(=O)O)cc2)O1.CN(C)c1ccncc1.CO.NN.O>>CC1(C)COB(c2ccc(C(=O)NN)cc2)O1",
        "output": "55"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N1CCC[C@@H]1CO.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CC(C)(C)OC(=O)N1CCC[C@@H]1C=O",
        "output": "610"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cc(O)c2ccc(C)cc2n1.Cl.[Na+].[OH-]>>Cc1ccc2c(O)cc(C(=O)O)nc2c1",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Nc1cccc(Cl)c1.O=C(NCC1CCCC1)c1cnc(Cl)cc1C1CC1>>O=C(NCC1CCCC1)c1cnc(Nc2cccc(Cl)c2)cc1C1CC1",
        "output": "434"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1ccc(N)c([N+](=O)[O-])c1.CCN(CC)CC.ClCCl.O=C(Cl)CCl>>CC(C)(C)c1ccc(NC(=O)CCl)c([N+](=O)[O-])c1",
        "output": "9"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CI.CN(C)C=O.Cc1cc(O)cc(C)c1Br.O.O=C([O-])[O-].[K+].[K+]>>COc1cc(C)c(Br)c(C)c1",
        "output": "62"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C.CCN(CC)CC.O.O=C(O)CCc1ccc([N+](=O)[O-])cc1.O=CO.[Pd]>>Nc1ccc(CCC(=O)O)cc1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(C)=O.CCOCC.C[C@H]1C[C@@H](c2ccncc2NC(=O)OCc2ccccc2)C[C@@H](NC(=O)OCc2ccccc2)C1=O.FB(F)F.OCCO>>C[C@H]1C[C@@H](c2ccncc2NC(=O)OCc2ccccc2)C[C@@H](NC(=O)OCc2ccccc2)C12OCCO2",
        "output": "265"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CI.C[C@H](O)COCc1ccccc1.[Cl-].[H-].[NH4+].[Na+]>>CO[C@@H](C)COCc1ccccc1",
        "output": "140"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1ccc(N)c(N)c1.CC(C)N(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@H]12)C(=O)CCCC(=O)O.CCN=C=NCCCN(C)C.ClCCl.On1nnc2ccccc21>>CC(C)N(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@H]12)C(=O)CCCC(=O)Nc1ccc(C(C)(C)C)cc1N",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CC#N.FC(F)(F)Oc1cccc(CBr)c1.O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NCC1CCNCC1.O=C=Nc1ccccc1>>O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NCC1CCN(Cc2cccc(OC(F)(F)F)c2)CC1",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[Si](C)(C)[N-][Si](C)(C)C.Clc1cc(Br)cc(CNC2CC2)c1Cl.[K+]>>CC(C)(C)OC(=O)N(Cc1cc(Br)cc(Cl)c1Cl)C1CC1",
        "output": "867"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1cc(OC)c(N)cc1F.[Na+].[OH-]>>COc1cc(C(=O)O)c(F)cc1N",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCc1ccccc1.CO.O=C([O-])O.O=C(c1ccccc1)c1cnc2[nH]ncc2c1O.[Na+]>>O=C(c1ccccc1)c1cnc2[nH]ncc2c1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)Cc1ccc(OCC(O)CN2CCCC(Cn3c(=O)[nH]c4cc(Cl)c(Cl)cc43)C2)cc1.N>>NC(=O)Cc1ccc(OCC(O)CN2CCCC(Cn3c(=O)[nH]c4cc(Cl)c(Cl)cc43)C2)cc1",
        "output": "432"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cn1cc(C(=O)N2CCC(c3ccc(F)cc3)CC2)c(Cl)c(Cl)c1=O.Nc1ccc2ocnc2c1>>Cn1cc(C(=O)N2CCC(c3ccc(F)cc3)CC2)c(Nc2ccc3ocnc3c2)c(Cl)c1=O",
        "output": "957"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCNCC1.COc1ccc(CN(Cc2ccc(OC)cc2)c2ncc(-c3nc(N4CCOCC4)nc4c3CCN4c3ccc(C(=O)O)cc3)cn2)cc1.COc1ccc(CN(Cc2ccc(OC)cc2)c2ncc(-c3nc(N4CCOCC4)nc4c3CCN4c3cccc(C(=O)O)c3)cn2)cc1>>COc1ccc(CN(Cc2ccc(OC)cc2)c2ncc(-c3nc(N4CCOCC4)nc4c3CCN4c3cccc(C(=O)N4CCN(C)CC4)c3)cn2)cc1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)[C@@H](N)CC(N)=O.Cl.O=C(O)c1cnc(C2CC2)c(OCC2CC2)n1>>CC(C)[C@H](CC(N)=O)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1",
        "output": "697"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.COc1ccc([C@H](N)CCO)cn1.Cc1ccc(N2CCc3ncnc(Cl)c3C2)nc1>>COc1ccc([C@@H](CCO)Nc2ncnc3c2CN(c2ccc(C)cn2)CC3)cn1",
        "output": "110"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OB(c2ccc(N)cc2)OC1(C)C.CCCC[N+](CCCC)(CCCC)CCCC.CCO.Cc1ccccc1.O=C([O-])[O-].OCCOCCOCCOc1ccc2cc(Br)ccc2n1.[Br-].[Na+].[Na+]>>Nc1ccc(-c2ccc3nc(OCCOCCOCCO)ccc3c2)cc1",
        "output": "933"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OCCCCn1c(=O)sc2c(=O)[nH]c(N)nc21.[NH4+].[OH-]>>Nc1nc2c(sc(=O)n2CCCCO)c(=O)[nH]1",
        "output": "225"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1ccccc1.CC(C)O.CC(C)[O-].CC(C)[O-].CC(C)[O-].Cl.[Al+3]>>CC(O)c1ccccc1",
        "output": "24"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CN(CCn1cnc(-c2cc3nccc(Oc4ccc([N+](=O)[O-])cc4F)c3s2)c1)C(=O)OC(C)(C)C.O.[Cl-].[Fe].[NH4+]>>CN(CCn1cnc(-c2cc3nccc(Oc4ccc(N)cc4F)c3s2)c1)C(=O)OC(C)(C)C",
        "output": "335"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COc1ccc2occc2c1.ClCCl>>Oc1ccc2occc2c1",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCCCNCC.CCN(CC)CC.Cc1nc(Cl)c(C)c(Cl)n1.Cl.O>>CCCCN(CC)c1nc(C)nc(Cl)c1C",
        "output": "296"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CCO.CCc1cc(N)nc(N)n1>>CCc1nc(N)nc(N)c1Br",
        "output": "381"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CC2CNCC21.O=C=NCc1ccc(Cl)cc1Cl>>CC(C)(C)OC(=O)N1CC2CN(C(=O)NCc3ccc(Cl)cc3Cl)CC21",
        "output": "583"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(-c2ccc(OCC3CCN(CC(F)(CC)CC)CC3)c(C#N)c2)cc1F.O.O.[Li]O>>CCC(F)(CC)CN1CCC(COc2ccc(-c3ccc(C(=O)O)c(F)c3)cc2C#N)CC1",
        "output": "5"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Oc1cc(Cl)c(Oc2ccc([N+](=O)[O-])cc2)c(Cl)c1C.CCOC(C)=O.O.O=[Pt]=O>>CC(=O)Oc1cc(Cl)c(Oc2ccc(N)cc2)c(Cl)c1C",
        "output": "335"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.Cc1cccc(-c2cc(Cl)nc(N)n2)c1C.NCCC(=O)N1CCOCC1>>Cc1cccc(-c2cc(NCCC(=O)N3CCOCC3)nc(N)n2)c1C",
        "output": "166"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.Cl.F[P-](F)(F)(F)(F)F.N#CC1(N)CC1.O=C(O)[C@H](CS(=O)(=O)Cc1ccccc1)OC(=O)N1CCOCC1>>N#CC1(NC(=O)[C@H](CS(=O)(=O)Cc2ccccc2)OC(=O)N2CCOCC2)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COC(=O)c1csc2cc(OC)ccc12.ClCCl>>COC(=O)c1csc2cc(O)ccc12",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCc1c(-c2ccc(C(=O)O)cc2C(=O)N2CCc3ccccc3C2)c(C(=O)OCC)nn1-c1ccccc1.CCCCc1c(-c2ccc(C(=O)OC(C)(C)C)cc2C(=O)N2Cc3ccccc3C[C@H]2CN=[N+]=[N-])c(C(=O)OCC)nn1-c1ccccc1>>CCCCc1c(-c2ccc(C(=O)O)cc2C(=O)N2Cc3ccccc3C[C@H]2CN=[N+]=[N-])c(C(=O)OCC)nn1-c1ccccc1",
        "output": "752"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.Clc1cc[c-](P(c2ccccc2)c2ccccc2)c1Cl.O=S(=O)(Nc1cc(Br)cnc1Cl)c1cccc(OC(F)F)c1.[Fe+2].[K+].[Pd+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2cnc(Cl)c(NS(=O)(=O)c3cccc(OC(F)F)c3)c2)OC1(C)C",
        "output": "943"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)C1CN(C(=O)c2cc(F)ccc2C)c2ccccc2CN1S(=O)(=O)c1ccc(OC)cc1.[Na+].[OH-]>>COc1ccc(S(=O)(=O)N2Cc3ccccc3N(C(=O)c3cc(F)ccc3C)CC2C(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCCCCCCCCCCN.CN(C)P(=O)(N(C)C)N(C)C.COC(=O)c1ccc(Cl)nc1.O>>CCCCCCCCCCCCCCCCNc1ccc(C(=O)OC)cn1",
        "output": "70"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccccc1.COC(=O)[C@H](CO)NC(c1ccccc1)(c1ccccc1)c1ccccc1.C[N+](C)(C)Cc1ccccc1.ClCCl.[Cl-].[Na+].[OH-]>>COC(=O)[C@H](COCc1ccccc1)NC(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "464"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Cc1cc(O)ccc1N.ClCCl>>Cc1cc(O)ccc1NC(=O)OC(C)(C)C",
        "output": "735"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cl.O=S(=O)(c1ccccc1)n1c(-c2cc(OCc3cccc(O)c3)[nH]n2)cc2ccccc21.[K+].[OH-]>>Oc1cccc(COc2cc(-c3cc4ccccc4[nH]3)n[nH]2)c1",
        "output": "771"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CCC(C1CCCC1)n1cc(-c2ncnc3c2ccn3COCC[Si](C)(C)C)cn1.ClCCl.O=C(O)C(F)(F)F>>C#CCC(C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1",
        "output": "897"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cc1c(Br)nn(-c2ccccc2)c1N.O=C(Cl)Oc1ccccc1.[Na+].[OH-]>>Cc1c(Br)nn(-c2ccccc2)c1NC(=O)Oc1ccccc1",
        "output": "700"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.C[O-].O=[N+]([O-])c1cc(Br)cc([N+](=O)[O-])c1.[Na+]>>COc1cc(Br)cc([N+](=O)[O-])c1",
        "output": "499"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COC(=O)c1ccc(OCc2c(-c3ccc(F)cc3)noc2CO)nc1.C[Al](C)C.Cc1ccccc1.NC1CCOCC1>>O=C(NC1CCOCC1)c1ccc(OCc2c(-c3ccc(F)cc3)noc2CO)nc1",
        "output": "862"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN1CCOCC1.CCOC(=O)C(C#N)=NOC(N(C)C)=[N+](C)C.CCOC(=O)N1CCNCC1.CCOC(C)=O.CN(C)C=O.CN(CC(=O)O)C(=O)OCc1ccccc1.F[B-](F)(F)F.O=C([O-])O.[Na+]>>CCOC(=O)N1CCN(C(=O)CN(C)C(=O)OCc2ccccc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCNC(=O)NOCC(=O)OC(C)(C)C.Cl>>CCNC(=O)NOCC(=O)O",
        "output": "278"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.CCN(CC)CC.Cl.ClCCl.O=C1CCC(c2ccccc2)(c2ccccc2)[C@@H]2CNC[C@H]12>>O=C1CCC(c2ccccc2)(c2ccccc2)[C@@H]2CN(Cc3ccccc3)C[C@H]12",
        "output": "248"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CN(C)CCNC(=O)c1cccc2nc3ccc4c(C#N)cccc4c3nc12.Cl.NO.O=C([O-])[O-].[K+].[K+]>>CN(C)CCNC(=O)c1cccc2nc3ccc4c(C(=N)NO)cccc4c3nc12",
        "output": "854"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCN=C=NCCCN(C)C.CCOc1ccc(C(=O)CCC(=O)O)cc1OCC.Nc1cc(-c2ccccc2)c(Cc2ccccc2)s1.On1nnc2ccccc21>>CCOc1ccc(C(=O)CCC(=O)Nc2cc(-c3ccccc3)c(Cc3ccccc3)s2)cc1OCC",
        "output": "882"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCBr.CCOC(C)=O.CN(C)C=O.O=[N+]([O-])c1cc[nH]n1.[H-].[Na+]>>CCCCCCCCn1ccc([N+](=O)[O-])n1",
        "output": "577"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.ClCCl.O=C(C1CCNCC1)N1CCN(c2ccncn2)CC1.O=C([O-])O.O=S(=O)(Cl)c1ccc(Cl)cc1.[Na+]>>O=C(C1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CCN(c2ccncn2)CC1",
        "output": "99"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(-c3cc(NC(N)=O)cc5[nH]ccc35)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12.N.O=C(O)C(F)(F)F>>Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cc(NC(N)=O)cc6[nH]ccc56)c34)n(-c3ccccc3)c(=O)c12",
        "output": "897"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.Cc1c(F)c(F)c([Si](C)(C)C)c(F)c1Br.O=C=O.[Cs+].[F-].[Li]CCCC>>Cc1c(F)c(F)c([Si](C)(C)C)c(F)c1C(=O)O",
        "output": "654"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[O-].CC(C)Oc1cccc(OC(C)C)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.CNCCN(C)C(=O)OC(C)(C)C.Cc1ccccc1.Cc1cncc(Br)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1cncc(N(C)CCN(C)C(=O)OC(C)(C)C)c1",
        "output": "597"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)c1ccccc1.CSc1ncc(CNc2ccc(Cl)cc2Cl)c(=O)[nH]1.O=P(Cl)(Cl)Cl>>CSc1ncc(CNc2ccc(Cl)cc2Cl)c(Cl)n1",
        "output": "14"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CC(C)(CC(=O)OCC)Cc1ccc(OCCCNc2ccccn2)cc1.CO.O.[Na+].[OH-]>>C=CC(C)(CC(=O)O)Cc1ccc(OCCCNc2ccccn2)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1cccc2c1NC(CNC(C)=O)CO2.ClCCl>>CC(=O)NCC1COc2cccc(O)c2N1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(O)Cc1ccccc1.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CC(=O)Cc1ccccc1",
        "output": "87"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N#CC1(N)CC1.O=C(O)c1ccc2cncc(-c3ccc(Cl)cc3)c2n1>>N#CC1(NC(=O)c2ccc3cncc(-c4ccc(Cl)cc4)c3n2)CC1",
        "output": "137"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCCCCC1C=CC(Oc2ccc(C(=O)O)o2)=C2N=C3CCCC(CCCCCCCC)C3=C21.CCCCCCCCC1C=CC(Oc2ccc(C(=O)OC)o2)=C2N=C3CCCC(c4cccc(OC)c4)C3=C21>>CCCCCCCCC1C=CC(Oc2ccc(C(=O)O)o2)=C2N=C3CCCC(c4cccc(OC)c4)C3=C21",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCN1.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COC(=O)c1ccc(C(=O)O)nc1.F[P-](F)(F)(F)(F)F>>COC(=O)c1ccc(C(=O)N2CCOCC2)nc1",
        "output": "605"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.ClCCl.N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1.On1nnc2ccccc21.[Na+].[OH-]>>CC(C)(C)OC(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCNCC2)c1.O=C(CCCCCl)c1ccc(C(F)(F)F)cc1>>CC(C)C(=O)Nc1cccc(C2CCN(CCCCC(=O)c3ccc(C(F)(F)F)cc3)CC2)c1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClC(Cl)Cl.NCC1CCOCC1.O.O=C(O)c1cc(COc2cccc(OC(F)(F)F)c2)on1.On1nnc2ccccc21>>O=C(NCC1CCOCC1)c1cc(COc2cccc(OC(F)(F)F)c2)on1",
        "output": "696"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCC.Cl.Cl[Sn](Cl)(Cl)Cl.O.O.O=C(c1ccc([N+](=O)[O-])cc1)N1CCN(c2ccccc2)CC1>>Nc1ccc(C(=O)N2CCN(c3ccccc3)CC2)cc1",
        "output": "28"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cc1n[nH]c(C)c1B1OC(C)(C)C(C)(C)O1.Cl.ClCCN1CCOCC1.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1nn(CCN2CCOCC2)c(C)c1B1OC(C)(C)C(C)(C)O1",
        "output": "604"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(C(=O)c2cccc(C)c2C)c(Cl)c1Cl.c1ccccc1>>Cc1cccc(C(=O)c2ccc(O)c(Cl)c2Cl)c1C",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.Cc1ncccc1CO.ClCCl.ClCCl.[Mn+4].[O-2].[O-2]>>Cc1ncccc1C=O",
        "output": "520"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.COC(=O)c1[nH]c(=O)n(CCCCCBr)c1Cc1ccc(F)c(F)c1.O=C([O-])[O-].[I-].[K+].[K+].[Na+].c1ccc(C2CCNCC2)cc1>>COC(=O)c1[nH]c(=O)n(CCCCCN2CCC(c3ccccc3)CC2)c1Cc1ccc(F)c(F)c1",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)CCN1CCN2CCCCC2C1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCN1CCN2CCCCC2C1",
        "output": "225"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc(C(C)C)ccc(CO)c1=O.ClC(Cl)Cl.[Mn+4].[O-2].[O-2]>>COc1cc(C(C)C)ccc(C=O)c1=O",
        "output": "179"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)COc1cc2c(c3c1c(C(=O)C(N)=O)c(C)n3Cc1ccccc1-c1ccc(Br)s1)CCC2.Cl.O.[Li+].[OH-]>>Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cc3c(c2n1Cc1ccccc1-c1ccc(Br)s1)CCC3",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Cl.CC(C)OC(C)C.CC(C)n1nc(-c2sc(N)nc2-c2ccccc2)ccc1=O.CCN(CC)CC.CN(C)C=O.CO.Cl.ClC(Cl)Cl>>CC(=O)Nc1nc(-c2ccccc2)c(-c2ccc(=O)n(C(C)C)n2)s1",
        "output": "553"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CNCCC#Cc1ccccn1.O=S(=O)(Cl)c1ccccc1Cl>>CN(CCC#Cc1ccccn1)S(=O)(=O)c1ccccc1Cl",
        "output": "99"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.O.O=C([O-])[O-].O=C(c1ccc2ncccc2c1)c1cnc2ccc(Cl)nn12.OB(O)c1ccccc1.[Cs+].[Cs+]>>O=C(c1ccc2ncccc2c1)c1cnc2ccc(-c3ccccc3)nn12",
        "output": "866"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.O=C(O)Cc1cccc(-c2cncc(Br)c2)c1.O=C([O-])O.O=S(Cl)Cl.[Na+]>>COC(=O)Cc1cccc(-c2cncc(Br)c2)c1",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C/C(=C\\c1ccc(CO)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C.CCOCC.[Mn+4].[O-2].[O-2]>>C/C(=C\\c1ccc(C=O)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C",
        "output": "179"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(Oc1ccccc1)C(=O)O.C[C@H]1C=CC2=C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O)[C@@H]2[C@H]1CC[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CC(=O)O1>>CCC(Oc1ccccc1)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O[Si](C)(C)C(C)(C)C)CC(=O)O3)[C@H]21",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CCCO.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Ic1ccc(C23CC4(c5ccc(I)cc5)CC(c5ccc(I)cc5)(C2)CC(c2ccc(I)cc2)(C3)C4)cc1.O.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>OCCC#Cc1ccc(C23CC4(c5ccc(I)cc5)CC(c5ccc(I)cc5)(CC(c5ccc(I)cc5)(C4)C2)C3)cc1",
        "output": "664"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1sc(N2C[C@H](C)N(Cc3ccc(F)cc3)C2=O)nc1C.Cl.O.[Li+].[OH-]>>Cc1nc(N2C[C@H](C)N(Cc3ccc(F)cc3)C2=O)sc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.CO.ClCCCl.N.O=C(O)Cc1ccc(Cc2cc(C(F)(F)F)nc(C3CCCC3)n2)cc1.On1nnc2ccccc21>>NC(=O)Cc1ccc(Cc2cc(C(F)(F)F)nc(C3CCCC3)n2)cc1",
        "output": "313"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)CCSc1ccccc1/C=C/C(=O)O.OC1CCNCC1>>CC(C)CCSc1ccccc1/C=C/C(=O)N1CCC(O)CC1",
        "output": "811"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.O.O=C1c2ccccc2C(=O)N1C1Cc2ccccc2C1.O=S(=O)(O)Cl>>O=C1c2ccccc2C(=O)N1C1Cc2ccc(S(=O)(=O)Cl)cc2C1",
        "output": "182"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CCC1(CC)C(=O)N(C)c2ccc(NC(C)=O)cc21.O=[N+]([O-])O>>CCC1(CC)C(=O)N(C)c2cc([N+](=O)[O-])c(NC(C)=O)cc21",
        "output": "21"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN.CN(C)C=O.COc1cc(C(=O)O)c(Br)cc1C(C)(C)C.Cl.On1nnc2ccccc21>>CNC(=O)c1cc(OC)c(C(C)(C)C)cc1Br",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(C)=O.Nc1ncc(CNCC2CC2)c(C(F)(F)F)n1>>CC(C)(C)OC(=O)N(Cc1cnc(N)nc1C(F)(F)F)CC1CC1",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.COC(=O)Cc1ccc2c(c1)CC(N)C2.Cl.O.O=C([O-])[O-].O=S(=O)(Cl)c1ccc(Cl)cc1.[K+].[K+]>>COC(=O)Cc1ccc2c(c1)CC(NS(=O)(=O)c1ccc(Cl)cc1)C2",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCc2sc(S(=O)(=O)Cl)cc2C1.ClCCl.Nc1ccccc1NS(=O)(=O)c1cc2ccccc2s1.c1ccncc1>>CC(C)(C)OC(=O)N1CCc2sc(S(=O)(=O)Nc3ccccc3NS(=O)(=O)c3cc4ccccc4s3)cc2C1",
        "output": "861"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN1C(=O)CCCc2cc(N)c(OC)cc21.NC(=O)[C@@H]1[C@H](Nc2nc(Cl)ncc2Cl)[C@H]2C=C[C@@H]1C2>>CCN1C(=O)CCCc2cc(Nc3ncc(Cl)c(N[C@@H]4[C@H]5C=C[C@H](C5)[C@@H]4C(N)=O)n3)c(OC)cc21",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1CNC(=NOCc2ccccc2)c2[nH]c3ccc(C(=O)O)cc3c21.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)c1ccncc1.F[P-](F)(F)(F)(F)F.Nc1cccnc1.O>>CC1CNC(=NOCc2ccccc2)c2[nH]c3ccc(C(=O)Nc4cccnc4)cc3c21",
        "output": "759"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.O=[N+]([O-])c1cnc2c(c1)C[C@@]1(CN3CCC1CC3)O2.[H][H].[Pd]>>Nc1cnc2c(c1)C[C@@]1(CN3CCC1CC3)O2",
        "output": "269"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1cc2c([nH]1)CCC2Cc1ccc2ccccc2c1.[Li+].[OH-]>>O=C(O)c1cc2c([nH]1)CCC2Cc1ccc2ccccc2c1",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.COC(CCC(O)c1cc(Cl)ncc1F)OC.ClCCl>>COC(CCC(=O)c1cc(Cl)ncc1F)OC",
        "output": "32"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cc(NS(=O)(=O)N(C)C)cc(-c2cn(COCC[Si](C)(C)C)c3ncnc(N[C@@H](C)c4nn5ccc(C)c5c(=O)n4-c4ccccc4)c23)c1.N.O=C(O)C(F)(F)F>>COc1cc(NS(=O)(=O)N(C)C)cc(-c2c[nH]c3ncnc(N[C@@H](C)c4nn5ccc(C)c5c(=O)n4-c4ccccc4)c23)c1",
        "output": "897"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN.O=C(Cl)c1ccccc1I>>CNC(=O)c1ccccc1I",
        "output": "271"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CS(=O)(=O)c1ccc(F)cc1F.NC1CCCc2ccccc21>>CS(=O)(=O)c1ccc(F)cc1NC1CCCc2ccccc21",
        "output": "764"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.Cc1noc(C)c1-c1ccc2c(Cl)c(C(N)=O)cnc2c1.Nc1cc(O)cc(C(=O)O)c1>>Cc1noc(C)c1-c1ccc2c(Nc3cc(O)cc(C(=O)O)c3)c(C(N)=O)cnc2c1",
        "output": "957"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.O.O=C([O-])C(CC1CC1)c1cc(OCC2CC2)c(Cl)c(-c2ccc(C(F)(F)F)cc2)c1.[Li+].[OH-]>>O=C(O)C(CC1CC1)c1cc(OCC2CC2)c(Cl)c(-c2ccc(C(F)(F)F)cc2)c1",
        "output": "151"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.c1ccc2[nH]c(C3CCNCC3)nc2c1>>CC(C)(C)OC(=O)N1CCC(c2nc3ccccc3[nH]2)CC1",
        "output": "694"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)O.CC(C)NC(C)C.CC(C)[N-]C(C)C.CN(C)C=O.COC(C)(C)C.Cl.Fc1cccc(Br)c1.O.[Li+].[Li]CCCC>>O=Cc1c(F)cccc1Br",
        "output": "239"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1CCC(C)N1.CCN(CC)CC.O=C(Cl)CCl.c1ccccc1>>CC1CCC(C)N1C(=O)CCl",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)OC(=O)CCCCCOc1cc2c(cc1N)nc(-c1ccccc1)n2-c1ccccc1.COc1ccc(S(=O)(=O)Cl)cc1>>COc1ccc(S(=O)(=O)Nc2cc3nc(-c4ccccc4)n(-c4ccccc4)c3cc2OCCCCCC(=O)OC(C)C)cc1",
        "output": "68"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br.Br.CCN(CC)CC.CN(C)C=O.O=S1(=O)c2cccc3cccc(c23)N1CCCCl.Oc1ccccc1N1CCNCC1>>O=S1(=O)c2cccc3cccc(c23)N1CCCN1CCN(c2ccccc2O)CC1",
        "output": "138"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.Cc1cccc(C(C)C)c1Br.O=[N+]([O-])O>>Cc1c([N+](=O)[O-])ccc(C(C)C)c1Br",
        "output": "21"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1nnc(C2CCN(C(=O)OC(C)(C)C)C(C)C2)o1.ClCCl.O=C(O)C(F)(F)F>>Cc1nnc(C2CCNC(C)C2)o1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.Cc1ccc(C(=O)Cl)cc1.Cc1nc([C@H](N)C(C)C)n(Cc2ccccc2)c(=O)c1C.ClCCl>>Cc1ccc(C(=O)N[C@@H](c2nc(C)c(C)c(=O)n2Cc2ccccc2)C(C)C)cc1",
        "output": "271"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)c1n[nH]c2cc(O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)ccc12.CCN(CC)CC.CN(C)c1ccncc1>>CC(C)c1nn(C(=O)OC(C)(C)C)c2cc(O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)ccc12",
        "output": "841"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CCN(C(C)C)C(C)C.COc1cc([N+](=O)[O-])c(F)cc1C>>COc1cc([N+](=O)[O-])c(NC2CCN(C(=O)OC(C)(C)C)CC2)cc1C",
        "output": "572"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(Br)C=O)CC1.CCn1nc(COCc2ccccc2)c(C)c1C1CCN(C(=O)OC(C)(C)C)CC1>>CCn1nc(CO)c(C)c1C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "178"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CO.F[P-](F)(F)(F)(F)F.Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12.O=C(O)c1nc(Cl)ccc1F>>O=C(Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12)c1nc(Cl)ccc1F",
        "output": "548"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "II.O.OO.c1ccc2c(c1)CCCN2>>Ic1ccc2c(c1)CCCN2",
        "output": "372"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COc1ccc(N)c(C)n1.ClCCl.O=C(Cl)Oc1ccccc1>>COc1ccc(NC(=O)Oc2ccccc2)c(C)n1",
        "output": "763"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(O)Cc1c(F)cccc1F.O=S(Cl)Cl>>O=C(Cl)Cc1c(F)cccc1F",
        "output": "53"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccc2c(c1)oc1ccccc12.[Pd]>>Nc1ccc2c(c1)oc1ccccc12",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)C1(c2cc(Cl)c(OCC(F)(F)F)c(-c3ccc(C(F)(F)F)cc3)c2)CC2(CC2)C1.CO.O.O.[Li+].[OH-]>>O=C(O)C1(c2cc(Cl)c(OCC(F)(F)F)c(-c3ccc(C(F)(F)F)cc3)c2)CC2(CC2)C1",
        "output": "615"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.O=C(O)c1ccc([N+](=O)[O-])cc1>>O=C(c1ccc([N+](=O)[O-])cc1)N1CCOCC1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc(NC2(c3ccccc3)CCC2)nc1.C1COCCO1.O.O=C([O-])O.O=C([O-])[O-].OB(O)c1ccccc1.[K+].[K+].[Na+]>>c1ccc(-c2ccc(NC3(c4ccccc4)CCC3)nc2)cc1",
        "output": "833"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrBr.ClCCl.Nc1ccc(-c2nc3c(F)cccc3s2)cc1>>Nc1ccc(-c2nc3c(F)cccc3s2)cc1Br",
        "output": "98"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1sc(Cl)nc1C(F)(F)F.Cl.O.[Na+].[OH-]>>O=C(O)c1sc(Cl)nc1C(F)(F)F",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Br.CC(C)(C)OC(=O)Nc1nccc(Cl)c1I.O.[Na+].[OH-]>>Nc1nccc(Cl)c1I",
        "output": "885"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COc1ccc(CC2CCC3NC(=O)C(CO)CC3C2)cc1.Cc1ccccc1.[BH4-].[Li+]>>COc1ccc(CC2CCC3NCC(CO)CC3C2)cc1",
        "output": "112"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCN(CC)CC.CNCCOC.COC(=O)[C@H](CCI)NC(=O)OC(C)(C)C>>COCCN(C)CC[C@H](NC(=O)OC(C)(C)C)C(=O)OC",
        "output": "184"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)Cc1c(C)c(Sc2ccc(Cl)cc2)n2ccccc12.Cl.[Li+].[OH-]>>Cc1c(CC(=O)O)c2ccccn2c1Sc1ccc(Cl)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)c1c(C)c(-c2cccc(C(F)(F)F)c2)nc2cc(OC(C)C)c(S(C)(=O)=O)cc12.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COC(=O)c1c(CBr)c(-c2cccc(C(F)(F)F)c2)nc2cc(OC(C)C)c(S(C)(=O)=O)cc12",
        "output": "625"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1ccc(OCc2ccc(C3CCN(C(=O)OC(C)(C)C)CC3)cn2)cc1F.Cl.O.O.[Li+].[OH-]>>CC(C)(C)OC(=O)N1CCC(c2ccc(COc3ccc(C(=O)O)c(F)c3)nc2)CC1",
        "output": "386"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)CO1.CCO.Cl.Ic1cnc(OCC2CCNCC2)cn1.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(O)CN1CCC(COc2cnc(I)cn2)CC1",
        "output": "76"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@@H](N)c1ccco1.Cl.Cn1nc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)c2ccc(F)cc21.F[P-](F)(F)(F)(F)F.O>>C[C@@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)c1ccco1",
        "output": "737"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(=O)CC1.ClCCCl.ClCCl.Nc1cccc(F)c1.[Na+]>>CC(C)(C)OC(=O)N1CCC(Nc2cccc(F)c2)CC1",
        "output": "469"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cl.ClCc1ccncc1.O=c1c(Cc2cccnc2)cn2c3c(cc(O)cc13)Sc1ccc(Br)cc1-2>>O=c1c(Cc2cccnc2)cn2c3c(cc(OCc4ccncc4)cc13)Sc1ccc(Br)cc1-2",
        "output": "49"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.NC(CCS)C(=O)O.OCCBr.[K+].[OH-]>>NC(CCSCCO)C(=O)O",
        "output": "185"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CSc1nc(Cl)c(F)c(Cl)n1.Cl.NCc1nccs1.O>>CSc1nc(Cl)c(F)c(NCc2nccs2)n1",
        "output": "166"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc(-c2nc3ccccc3nc2-c2ccccc2)cc1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)[O-].Cc1ccccc1C.O.[Na+].c1ccc(-c2ccc3[nH]c4ccc(-c5ccccc5)cc4c3c2)cc1>>c1ccc(-c2ccc3c(c2)c2cc(-c4ccccc4)ccc2n3-c2ccc(-c3nc4ccccc4nc3-c3ccccc3)cc2)cc1",
        "output": "349"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCOC(C)=O.CCOC(C)OC(CC)C(C)C1OC1CC(C)/C=C/C=C(\\C)C1OC(=O)CC(O)CCC(C)(OC(C)OCC)C(OC(C)=O)C=CC1C.CCOCC(=O)O.CN(C)c1ccccn1.ClCCl>>CCOCC(=O)OC1CCC(C)(OC(C)OCC)C(OC(C)=O)C=CC(C)C(/C(C)=C/C=C/C(C)CC2OC2C(C)C(CC)OC(C)OCC)OC(=O)C1",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(N)CN.CCOCC.O=C(Cl)Cc1ccccc1>>CC(C)(N)CNC(=O)Cc1ccccc1",
        "output": "45"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)N1CCN(C(=O)c2cc3nccc(Cl)c3s2)CC1.Cc1cc2cc(N)ccc2[nH]1>>CC(=O)N1CCN(C(=O)c2cc3nccc(Nc4ccc5[nH]c(C)cc5c4)c3s2)CC1",
        "output": "927"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#CCNc1nc(C)c(C(=O)N[C@@H](CNC(=O)c2cccs2)C(=O)OC)c(C)n1.CCN(CC)CC.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Oc1cc(F)cc(Br)c1.[Cu]I>>COC(=O)[C@H](CNC(=O)c1cccs1)NC(=O)c1c(C)nc(NCC#Cc2cc(O)cc(F)c2)nc1C",
        "output": "659"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.CCOC(=O)C1=Cc2ccccc2OC1C(F)(F)F.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CCOC(=O)C1=Cc2cc(C(C)=O)ccc2OC1C(F)(F)F",
        "output": "31"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.Cc1ccccc1.O=C(O)c1ccc(F)c(Cl)c1F.O=S(Cl)Cl>>O=C(Cl)c1ccc(F)c(Cl)c1F",
        "output": "3"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#Cc1ccccn1.Nc1ncc(CNc2cc(C(=O)NC3CC3)ccc2F)cc1Br>>Nc1ncc(CNc2cc(C(=O)NC3CC3)ccc2F)cc1C#Cc1ccccn1",
        "output": "719"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.O=[N+]([O-])c1ccc(N2CC[C@@H](O)C2)c(CO)c1>>Nc1ccc(N2CC[C@@H](O)C2)c(CO)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OB(c2ccc(N)nc2)OC1(C)C.FC(F)(F)c1cc(-c2ccc(Cl)cc2)cc(-c2cccc(Br)c2)n1>>Nc1ccc(-c2cccc(-c3cc(-c4ccc(Cl)cc4)cc(C(F)(F)F)n3)c2)cn1",
        "output": "954"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#CCNC(=O)OC(C)(C)C.FC(F)(F)Oc1ccc(I)cc1>>CC(C)(C)OC(=O)NCC#Cc1ccc(OC(F)(F)F)cc1",
        "output": "664"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[O-].CCOC(C)=O.CN(C)C=O.Cc1cc(N)c2c(C)c(-c3cccnc3)sc2n1.O.O=S(=O)(Cl)c1cccc(Cl)c1.[Na+]>>Cc1cc(NS(=O)(=O)c2cccc(Cl)c2)c2c(C)c(-c3cccnc3)sc2n1",
        "output": "68"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)[O-].COc1cc(OC)c(Cl)c(N2Cc3cnc4c(cc(Br)n4S(=O)(=O)c4ccccc4)c3N(C)C2=O)c1.[K+]>>COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]c(Br)cc4c3N(C)C2=O)c1",
        "output": "831"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CNc1ncnc2ccc(C=O)cc12.N=C1NC(=O)CS1>>CNc1ncnc2ccc(C=C3SC(=N)NC3=O)cc12",
        "output": "314"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNC1.CC#N.CCN(CC)CC.O=C=NCc1ccc(Br)cc1>>O=C(NCc1ccc(Br)cc1)N1CCCC1",
        "output": "583"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.C1COCCO1.Cc1cccc(NS(=O)(=O)c2ccc(Cl)nc2)n1>>Cc1cccc(NS(=O)(=O)c2ccc(N3CCCCC3)nc2)n1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C#N)c1ccc(Nc2c([N+](=O)[O-])cnc3ccc(Br)cc23)cc1.CO.[Ni]>>CC(C)(C#N)c1ccc(Nc2c(N)cnc3ccc(Br)cc23)cc1",
        "output": "269"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CCO.CCOc1cc(C=O)cc(OCC)c1-n1cccc1.Cc1nccc2nc(NC3CCNCC3)oc12.[BH3-]C#N.[Na+]>>CCOc1cc(CN2CCC(Nc3nc4ccnc(C)c4o3)CC2)cc(OCC)c1-n1cccc1",
        "output": "567"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)O)CC1.Cc1cc(CN)ccc1F>>CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)NCc2ccc(F)c(C)c2)CC1",
        "output": "599"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccccc1.ClCCCBr.O.O=S(=O)([O-])O.OCCc1ccc2sccc2c1.[Na+].[OH-]>>ClCCCOCCc1ccc2sccc2c1",
        "output": "95"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br.Nc1ccc(-c2c[nH]c(=O)cn2)cc1.O=C(Cl)c1ccccc1.[Na+].[OH-]>>O=C(Nc1ccc(-c2c[nH]c(=O)cn2)cc1)c1ccccc1",
        "output": "11"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCC.CCOC(C)=O.Cl.N#Cc1cccc(N)c1.O.O=N[O-].[N-]=[N+]=[N-].[Na+].[Na+]>>N#Cc1cccc(N=[N+]=[N-])c1",
        "output": "189"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1CCCC1=O.COC(=O)c1ccc2[nH]c(=O)c(Cl)nc2c1.C[C@H]1CN(c2ccccn2)CCN1>>COC(=O)c1ccc2[nH]c(=O)c(N3CCN(c4ccccn4)C[C@@H]3C)nc2c1",
        "output": "505"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO[C@@H](Cc1ccc(O)cc1OC)C(=O)OC.Cc1cc(-c2nc(CCl)c(C)o2)ccc1F.O=C([O-])[O-].[Cs+].[Cs+].[I-].[K+]>>CCO[C@@H](Cc1ccc(OCc2nc(-c3ccc(F)c(C)c3)oc2C)cc1OC)C(=O)OC",
        "output": "760"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(O)CNCc1cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c2o1.ClCCCl.O=C([O-])O.[Na+].[Na+]>>CC(O)CN(C)Cc1cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c2o1",
        "output": "217"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.CN(C)C=O.N#Cc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>N#Cc1ccc(OCc2ccccc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.CCN(CC)CC.CCO.CCOC(C)=O.CCOC(C)=O.CCOCC.CO.Cc1sc(N)nc1-c1ccc(CCCl)cc1.Cl.O=C([O-])[O-].[I-].[Na+].[Na+].[Na+].c1ccc2c(N3CCNCC3)cccc2c1>>Cc1sc(N)nc1-c1ccc(CCN2CCN(c3cccc4ccccc34)CC2)cc1",
        "output": "138"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1ccc(-c2nocc2C(=O)O)cc1.F[B-](F)(F)F.OC1(c2ccc(F)cc2)CCNC1>>Cc1ccc(-c2nocc2C(=O)N2CCC(O)(c3ccc(F)cc3)C2)cc1",
        "output": "975"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCCCC1.CC1(C)OB(c2cnc(NCC(F)(F)F)nc2)OC1(C)C.CCOC(C)=O.Clc1nc(NCC(c2ccccc2)c2ccccc2)c2ccccc2n1.c1ccc(C(Nc2nc(-c3cc4ccccc4s3)nc3ccccc23)c2ccccc2)cc1>>FC(F)(F)CNc1ncc(-c2nc(NCC(c3ccccc3)c3ccccc3)c3ccccc3n2)cn1",
        "output": "973"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.ClCCl.Nc1ccccc1.O.O=C(O)c1ccc(Oc2ccc3ccccc3c2)cc1.[Cl-]>>O=C(Nc1ccccc1)c1ccc(Oc2ccc3ccccc3c2)cc1",
        "output": "50"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)C[C@H](C=CCCCCc1ccc2c(n1)NCCCC2)c1cnc(C)nc1.[H][H].[Pd]>>CCOC(=O)C[C@H](CCCCCCc1ccc2c(n1)NCCCC2)c1cnc(C)nc1",
        "output": "143"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC[C@@H](N)CO.COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(=O)(=O)CCCCl)CC2)nc1N>>CC[C@H](CO)NCCCS(=O)(=O)N1CCC(Nc2ncc(C(=O)c3c(OC)ccc(F)c3F)c(N)n2)CC1",
        "output": "279"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(CNc2ccc(C(C)C)cc2)nc1.COc1ccc2c(c1)C(C(=O)O)CCC2>>COc1ccc(CN(C(=O)C2CCCc3ccc(OC)cc32)c2ccc(C(C)C)cc2)nc1",
        "output": "315"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@H]1CN(c2ccncc2N)C[C@@H](NC(=O)OC(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2ccn(C3CCC3)c2n1>>C[C@H]1CN(c2ccncc2NC(=O)c2ccc3ccn(C4CCC4)c3n2)C[C@@H](NC(=O)OC(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C",
        "output": "776"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)N1CCC(=O)C(CC)C1.CO.NC1CC1.[BH3-]C#N.[Na+]>>CCOC(=O)N1CCC(NC2CC2)C(CC)C1",
        "output": "236"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)[C@@H](N)[C@H](O)c1ccc(S(C)(=O)=O)cc1.CO.Cl.O.[BH4-].[K+]>>CS(=O)(=O)c1ccc([C@@H](O)[C@H](N)CO)cc1",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC[C@H](c1ccc(C(F)(F)F)cc1)N(Cc1ccc(C(=O)OC)cc1)S(=O)(=O)c1ccc(Cl)cc1.O.[Li+].[OH-]>>CC[C@H](c1ccc(C(F)(F)F)cc1)N(Cc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccc(Cl)cc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CCc1cc(C(F)(F)F)n[nH]1.ClC(Cl)Cl.O=C1CCC(=O)N1Br>>CCc1[nH]nc(C(F)(F)F)c1Br",
        "output": "620"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrC(Br)(Br)Br.CCC(CC)n1cc(CCCCO)c(=O)c2cc(F)c(NC3CCCCC3)cc21.ClCCCl.O=C([O-])O.[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCC(CC)n1cc(CCCCBr)c(=O)c2cc(F)c(NC3CCCCC3)cc21",
        "output": "378"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Br.BrBr.CCC(=O)c1ccc(Cl)cc1.ClCCl>>CC(Br)C(=O)c1ccc(Cl)cc1",
        "output": "82"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.COC(=O)c1cc(CN)ccc1[N+](=O)[O-].Cl.ClCCl>>COC(=O)c1cc(CNC(=O)OC(C)(C)C)ccc1[N+](=O)[O-]",
        "output": "686"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)[C@H]1C[C@@H](Nc2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)c(F)c2)C1.Cl.[Na+].[OH-]>>O=C(O)[C@H]1C[C@@H](Nc2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)c(F)c2)C1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)c(OCc2ccccc2)c1)C(=O)OCc1ccccc1.CO.Cl.O.[Na+].[OH-]>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)c(OCc2ccccc2)c1)C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CNC(C)(C)C.Cl.O.O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1.On1nnc2ccccc21>>CN(C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C",
        "output": "605"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Br.CC1CNCCc2nc(O)ccc21.CCN(CC)CC.CN(C)C=O.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CC1CN(C(=O)C(F)(F)F)CCc2nc(O)ccc21",
        "output": "397"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1CO.CI.CN(C)C=O.[H-].[Na+]>>COC[C@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)OC(C)(C)C",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)S(=O)(=O)c1cc2c(Nc3ccc4scnc4c3)ncnc2cc1OCCO.CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)c1ccncc1.F[P-](F)(F)(F)(F)F>>CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)OCCOc1cc2ncnc(Nc3ccc4scnc4c3)c2cc1S(=O)(=O)C(C)(C)C",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(C)=O.O.O=CO[K].O=[N+]([O-])c1ccc(Oc2ccnc3cc(OCCO)ccc23)cc1.[Pd]>>Nc1ccc(Oc2ccnc3cc(OCCO)ccc23)cc1",
        "output": "335"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1c(N=C(c2ccccc2)c2ccccc2)ccc(C#N)c1C(F)(F)F.ClC(Cl)(Cl)Cl.ClCCl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>N#Cc1ccc(N=C(c2ccccc2)c2ccccc2)c(CBr)c1C(F)(F)F",
        "output": "29"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)c1ccc2c(c1)CN(CCCCNC(=O)C(F)(F)F)CC2.CO.O.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1ccc2c(c1)CN(CCCCN)CC2",
        "output": "805"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCC.CCOC(C)=O.CN(C)C=O.Clc1ccccc1CBr.OCCCO.[H-].[Na+]>>OCCCOCc1ccccc1Cl",
        "output": "464"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C(Cc1ccc(OCc2sc(-c3ccccc3)nc2C)cc1C)OCC.[Li+].[OH-]>>CCOC(Cc1ccc(OCc2sc(-c3ccccc3)nc2C)cc1C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3ncc4c5ccnc(C#N)c5n(C5CCCC5)c4n3)nc2)CC1.CO.Cl>>N#Cc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(O)CN.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.O=[N+]([O-])c1c(Cl)nc2ccccc2c1Cl>>CC(C)(O)CNc1c([N+](=O)[O-])c(Cl)nc2ccccc12",
        "output": "78"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CS(C)=O.O=C(O)c1cn(Cc2ccc(Cl)nn2)c2c(F)cccc2c1=O>>O=C(O)c1cn(Cc2ccc(N3CCCCC3)nn2)c2c(F)cccc2c1=O",
        "output": "406"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.COC(=O)[C@@H]1CN(CCn2c(=O)ccc3c(F)cc(F)cc32)CC[C@H]1N.O=Cc1cc2c(cn1)OCCO2.[Na+]>>COC(=O)[C@@H]1CN(CCn2c(=O)ccc3c(F)cc(F)cc32)CC[C@H]1NCc1cc2c(cn1)OCCO2",
        "output": "775"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)C=Nc1[nH]nc(-c2ccc(N)cc2)c1C#N>>CN(C)C=Nc1[nH]nc(-c2ccc(NC(=O)OC(C)(C)C)cc2)c1C#N",
        "output": "735"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CCOC(=O)c1c(Cl)cc(Cl)nc1C.Cl.O.[OH-]>>Cc1nc(Cl)cc(Cl)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)c1c(C(=O)OC)c2c(-c3ccc(OCc4ccccc4)cc3)cc3c(CO[Si](C)(C)C(C)(C)C)ccc1n32.O=S(=O)(O)O>>COC(=O)c1c(C(=O)OC)c2c(-c3ccc(OCc4ccccc4)cc3)cc3c(CO)ccc1n32",
        "output": "708"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Clc1ccccc1OC1CNC1.O=C(O)CNC(=O)c1cc(-c2ccccc2)[nH]n1.On1nnc2ccccc21>>O=C(NCC(=O)N1CC(Oc2ccccc2Cl)C1)c1cc(-c2ccccc2)[nH]n1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl.NC1CCN(Cc2ccccc2)CC1.O.O=C(O)Cc1ccc(F)cc1.On1nnc2ccccc21>>O=C(Cc1ccc(F)cc1)NC1CCN(Cc2ccccc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCOC(=O)c1cc2cccc([Si](C)(C)C)c2n1Cc1cccc(F)c1.CO.O.[K+].[OH-]>>C[Si](C)(C)c1cccc2cc(C(=O)O)n(Cc3cccc(F)c3)c12",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCc1ncc(C(=O)[O-])o1.CO.[Na+].[OH-]>>CCc1ncc(C(=O)O)o1",
        "output": "151"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COc1cccc(CC(C)NC(=O)C(F)(F)F)c1.ClI.O=C([O-])[O-].[Ca+2]>>COc1ccc(I)c(CC(C)NC(=O)C(F)(F)F)c1",
        "output": "466"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Oc1ccc(C)cc1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>CC(=O)Oc1ccc(CBr)cc1",
        "output": "29"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.O=C(Cl)CCl.O=C1CCc2ccccc2N1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C1CCc2cc(C(=O)CCl)ccc2N1",
        "output": "31"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.OCCCCCCO.[H-].[Na+]>>CC(C)(C)[Si](C)(C)OCCCCCCO",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[O-].ClCCCl.Clc1cc(C(Cl)(Cl)Cl)nc(Cl)n1.[Na+]>>COc1cc(C(Cl)(Cl)Cl)nc(Cl)n1",
        "output": "653"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COC(=O)c1cc(Cc2c(C)c(OC)c(OC)c(OC)c2OC)ccc1OCc1ccncc1.Cl.O.[Na+].[OH-]>>COc1c(C)c(Cc2ccc(OCc3ccncc3)c(C(=O)O)c2)c(OC)c(OC)c1OC",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.COC(=O)[C@@H](NC(=O)c1ccc(-c2ccc(OC)cc2)cc1N)[C@@H](C)OC(C)(C)C.Cc1cc(C2CC2)cc(C)c1N=C=O>>COC(=O)[C@@H](NC(=O)c1ccc(-c2ccc(OC)cc2)cc1NC(=O)Nc1c(C)cc(C2CC2)cc1C)[C@@H](C)OC(C)(C)C",
        "output": "993"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCO.CN1CCCC1=O.Nc1nc(Cl)ccc1C(=O)NCc1ccc(Oc2ccccc2)cc1.O.[H-].[Na+]>>CCCCOc1ccc(C(=O)NCc2ccc(Oc3ccccc3)cc2)c(N)n1",
        "output": "433"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CN(C)C=O.Nc1ccc(Cl)c(S(N)(=O)=O)c1O.O=C=NCCc1ccccc1>>NS(=O)(=O)c1c(Cl)ccc(NC(=O)NCCc2ccccc2)c1O",
        "output": "176"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCNCC1.CCOC(C)=O.O=C=Nc1ccccc1>>CC(C)(C)OC(=O)N1CCN(C(=O)Nc2ccccc2)CC1",
        "output": "323"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cl.NC1(C(=O)O)CCOCC1>>COC(=O)C1(N)CCOCC1",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COCCOc1ccc([N+](=O)[O-])cc1.[Pd]>>COCCOc1ccc(N)cc1",
        "output": "202"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.Nc1ncnc2c1c(-c1cccc(OCC3CCCCO3)c1)cn2[C@@H]1C[C@H](CO)C1>>Nc1ncnc2c1c(-c1cccc(OCC3CCCCO3)c1)cn2[C@@H]1C[C@H](C=O)C1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)c1cc(CC=Cc2ccccc2)c(O)c(C(C)(C)C)c1.[H][H].[Pd]>>CC(C)(C)c1cc(CCCc2ccccc2)c(O)c(C(C)(C)C)c1",
        "output": "362"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCBr.CN(C)C=O.O=Cc1cccc(O)c1.[H-].[Na+]>>CCCCOc1cccc(C=O)c1",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(=O)Cl.N#Cc1ccc(NCCCCCCO)c([N+](=O)[O-])c1.c1ccncc1>>CC(C)(C)C(=O)OCCCCCCNc1ccc(C#N)cc1[N+](=O)[O-]",
        "output": "126"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(C)=O.Cc1c(N)cccc1O.N#CCBr.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1c(N)cccc1OCC#N",
        "output": "802"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)c1ccc(S(=O)(=O)Cl)cc1.CCN(CC)CC.Nc1ccc(C2CCN(Cc3ccccc3)C2)cc1F>>CC(C)c1ccc(S(=O)(=O)Nc2ccc(C3CCN(Cc4ccccc4)C3)cc2F)cc1",
        "output": "68"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)C(C)NC(=O)c1ccc(C(C)(C)C)cc1.Cl.[Na+].[OH-]>>CC(NC(=O)c1ccc(C(C)(C)C)cc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)/C=C/c1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)cn(C)c2c1.CO.[Na+].[OH-]>>CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(/C=C/C(=O)O)ccc23)cc1",
        "output": "122"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCCOC.Cl[Pd]Cl.N#Cc1cc(Br)ccc1N.O.O=C([O-])[O-].OB(O)c1ccc(C(F)(F)F)cc1.[K+].[K+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1cc(-c2ccc(C(F)(F)F)cc2)ccc1N",
        "output": "837"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.CC(C)(C)[Si](C)(C)OCCNc1nnc(-c2c(Nc3ccc(Br)cc3F)c(F)c(=O)n3c2CCC3)o1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.O.[F-]>>O=c1c(F)c(Nc2ccc(Br)cc2F)c(-c2nnc(NCCO)o2)c2n1CCC2",
        "output": "708"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccccc1.Nc1ccc2c(O)cccc2c1.O=C1OC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1c1ccc2c(O)cccc2c1",
        "output": "475"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NCCCn1ccnc1.O=C(O)c1cc(Br)ncc1Nc1ccc(I)cc1F>>O=C(NCCCn1ccnc1)c1cc(Br)ncc1Nc1ccc(I)cc1F",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCc1ccc(C2CNCC(C(=O)Nc3ccccc3)C2)cc1.COCCOC(=O)Cl>>CCc1ccc(C2CC(C(=O)Nc3ccccc3)CN(C(=O)OCCOC)C2)cc1",
        "output": "219"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(O)CC1CCN(C(=O)OCc2ccccc2)CC1.CO.[C].[Pd]>>CC(C)(O)CC1CCNCC1",
        "output": "428"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1cc(N)ccc1Br.ClCCl.[Na+].[OH-]>>Cc1cc(NS(C)(=O)=O)ccc1Br",
        "output": "194"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.COC(=O)Nc1nc2c(Br)cc(Oc3ccc([N+](=O)[O-])cc3)cc2s1.[Zn]>>COC(=O)Nc1nc2c(Br)cc(Oc3ccc(N)cc3)cc2s1",
        "output": "335"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COC(=O)c1ccc(Cn2c(=O)[nH]c3ccccc3c2=O)cc1.Cc1ccc(CBr)cc1.ClCCl.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(Cn2c(=O)c3ccccc3n(Cc3ccc(C)cc3)c2=O)cc1",
        "output": "389"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Cn1c(C(=O)O)cc2ccccc21.CC(C)[C@H](N)C(=O)NC(CC(=O)OC(C)(C)C)C(O)COc1c(F)c(F)cc(F)c1F.CCN=C=NCCCN(C)C.CN1CCOCC1.ClCCl.On1nnc2ccccc21>>CC(C)[C@H](NC(=O)c1cc2ccccc2n1CC(=O)OC(C)(C)C)C(=O)NC(CC(=O)OC(C)(C)C)C(O)COc1c(F)c(F)cc(F)c1F",
        "output": "738"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CC(N=[N+]=[N-])CC(C(=O)Nc2ccc(Cl)cc2)C1.ClCCl.O=C(O)C(F)(F)F>>[N-]=[N+]=NC1CNCC(C(=O)Nc2ccc(Cl)cc2)C1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.ClCCl.Cn1cc(-c2cc3c(cc2C(F)F)N(c2n[nH]c4c2CN(C(=O)OC(C)(C)C)CC4)CCC3)cn1.O.OB(O)c1ccccc1.[Cu+2]>>Cn1cc(-c2cc3c(cc2C(F)F)N(c2nn(-c4ccccc4)c4c2CN(C(=O)OC(C)(C)C)CC4)CCC3)cn1",
        "output": "925"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCc1ccc(C2CC(C(=O)O)CN(C(=O)N3CCOCC3)C2)cc1.N=C(Cc1ccc(F)cc1Cl)NO>>CCc1ccc(C2CC(c3nc(Cc4ccc(F)cc4Cl)no3)CN(C(=O)N3CCOCC3)C2)cc1",
        "output": "924"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CCOC(=O)C1CCC(=O)C(CC)C1C.CO.[BH4-].[Na+]>>CCOC(=O)C1CCC(O)C(CC)C1C",
        "output": "91"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.C=C(OCC)c1cc(COCC2CC2)nc(Cl)n1.CC(=O)[O-].CC(=O)[O-].COc1cc(N)ccc1-n1cnc(C)c1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(-c2ccccc2P(C2CCCCC2)C2CCCCC2)cc1>>C=C(OCC)c1cc(COCC2CC2)nc(Nc2ccc(-n3cnc(C)c3)c(OC)c2)n1",
        "output": "808"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Clc1ncc(-c2c[nH]cn2)cn1.O=C1c2ccccc2C(=O)N1CCCCBr.[H-].[Na+]>>O=C1c2ccccc2C(=O)N1CCCCn1cnc(-c2cnc(Cl)nc2)c1",
        "output": "276"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCc1ccc(Cl)cc1.O=C(O)c1ccc2c(=O)n(-c3ncccc3O)c(=S)[nH]c2c1>>O=C(NCc1ccc(Cl)cc1)c1ccc2c(=O)n(-c3ncccc3O)c(=S)[nH]c2c1",
        "output": "753"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC[SiH](CC)CC.CSc1ccccc1C(=O)c1cc(C)ccc1C.O.O=C(O)C(F)(F)F>>CSc1ccccc1Cc1cc(C)ccc1C",
        "output": "181"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(Cc1ccccc1OCc1ccccc1)c1ccc(C(=O)OC(C)(C)C)c(F)c1.CCOCC.O=CO>>CCN(Cc1ccccc1OCc1ccccc1)c1ccc(C(=O)O)c(F)c1",
        "output": "752"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)C(C)(C)c1cc(Br)c2c(c1)cc(-c1ccc(OC(F)(F)F)cc1)n2CC(=O)NC(C)(C)C.CO.[K+].[OH-]>>CC(C)(C)NC(=O)Cn1c(-c2ccc(OC(F)(F)F)cc2)cc2cc(C(C)(C)C(=O)O)cc(Br)c21",
        "output": "615"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.COc1cc2ncnc(Oc3ccc(OCC(=O)O)cc3)c2cc1OC.Cl.ClC(Cl)Cl.O.O=C([O-])O.On1nnc2ccccc21.[Na+].c1ccc(C2CCNCC2)cc1>>COc1cc2ncnc(Oc3ccc(OCC(=O)N4CCC(c5ccccc5)CC4)cc3)c2cc1OC",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)CN(C[C@@H](O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)O[C@@H]1CO[C@H]2OCC[C@H]21)S(=O)(=O)c1ccc([N+](=O)[O-])cc1.CCO.[H][H].[Pt]>>CC(C)CN(C[C@@H](O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)O[C@@H]1CO[C@H]2OCC[C@H]21)S(=O)(=O)c1ccc(N)cc1",
        "output": "401"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Nc1nc2ccc(Oc3ccc(F)c(NC(=O)C(F)(F)F)c3)c(C#N)c2s1.CCO.CO.[BH4-].[Na+]>>CC(=O)Nc1nc2ccc(Oc3ccc(F)c(N)c3)c(C#N)c2s1",
        "output": "491"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1cccc2cnccc12.Nc1nccc2cnccc12.O=C(O)C1CCN(c2cccc3cnccc23)CC1>>O=C(Nc1nccc2cnccc12)C1CCN(c2cccc3cnccc23)CC1",
        "output": "368"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cl.Nc1cc(OC(F)(F)F)ccc1OC1CC1.O.O=N[O-].[I-].[K+].[Na+]>>FC(F)(F)Oc1ccc(OC2CC2)c(I)c1",
        "output": "200"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NC[C@@H]1[C@H]2C[C@H]2CN1C(=O)c1nc(N)sc1-c1cccc(F)c1.O=C(O)c1n[nH]c2ccccc12>>Nc1nc(C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2n[nH]c3ccccc23)c(-c2cccc(F)c2)s1",
        "output": "816"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)C[C@@H]1CCOS(C)(=O)=O.CN(C)C=O.O=C([O-])O.Oc1ccccc1.[I-].[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)C[C@@H]1CCOc1ccccc1",
        "output": "702"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=C(O)c1cc(Cl)cc2c1OCCN2.O=S(=O)(O)O>>COC(=O)c1cc(Cl)cc2c1OCCN2",
        "output": "33"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.N.N#Cc1cccc2ncccc12.[Ni]>>NCc1cccc2ncccc12",
        "output": "175"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCN(CC)CC.NCCc1ccc(O)cc1.O=C(O)CCCCCBr.O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O>>O=C(CCCCCBr)NCCc1ccc(O)cc1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CNOC.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O.O=C(O)c1ccc(-n2cnnn2)cc1>>CON(C)C(=O)c1ccc(-n2cnnn2)cc1",
        "output": "828"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCNC1.CCOC(C)=O.CN(C)S(=O)(=O)c1ccc(F)cc1.CS(C)=O.O.O=C([O-])[O-].[Ca].[K+].[K+]>>CN(C)S(=O)(=O)c1ccc(N2CC[C@H](NC(=O)OC(C)(C)C)C2)cc1",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)Cc1ccc(-c2ccc(-c3cc(C(F)(F)F)nn3-c3ccccc3Cl)s2)c(C)c1.Cl.O.O.[Li+].[OH-]>>Cc1cc(CC(=O)O)ccc1-c1ccc(-c2cc(C(F)(F)F)nn2-c2ccccc2Cl)s1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)CN1C(=O)Cc2cc(Cl)ccc21.Cl>>O=C(O)CN1C(=O)Cc2cc(Cl)ccc21",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Cl.O=C(O)c1c[nH]c2c(F)cccc12>>COC(=O)c1c[nH]c2c(F)cccc12",
        "output": "521"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)c1ccc(C(C)C)cc1.Cc1ccccc1.NN.O.O=C([O-])O.[Na+]>>CC(C)c1ccc(C(=O)NN)cc1",
        "output": "421"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=CCOC(=O)N1CCSCC1C(=O)OCC.CO.Cl.[Na+].[OH-]>>C=CCOC(=O)N1CCSCC1C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CC1.CN(C)C=O.Cc1c(-c2ccc(O)cc2)nc2n(Cc3c(F)cccc3F)cc(Br)c(=O)n12.O=C([O-])[O-].[K+].[K+]>>Cc1c(-c2ccc(OCC3CC3)cc2)nc2n(Cc3c(F)cccc3F)cc(Br)c(=O)n12",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Nc1ccc(Br)cc1-c1ccccc1.CCO.Cl>>Nc1ccc(Br)cc1-c1ccccc1",
        "output": "66"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(CC(=O)NC(c2ccc(C)cc2)c2ccccc2N2CCCCC2)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>Cc1ccc(C(NC(=O)Cc2ccc(CO)cc2)c2ccccc2N2CCCCC2)cc1",
        "output": "311"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C)OCC(C(O)CN)O1.CCN(CC)CC.CCOC(C)=O.O=C(O)c1cccc(S(=O)(=O)Nc2ccc(F)cc2C(F)(F)F)c1.O=S(Cl)Cl>>CC1(C)OCC(C(O)CNC(=O)c2cccc(S(=O)(=O)Nc3ccc(F)cc3C(F)(F)F)c2)O1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(N)ccc3N2)c(O)c2cccnc21.O=S(=O)(Cl)CCl.c1ccncc1>>CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(NS(=O)(=O)CCl)ccc3N2)c(O)c2cccnc21",
        "output": "194"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc2c(-c3ccccc3)c(C(=O)c3cccc(Cl)c3)sc2c1.Cl.c1ccncc1>>O=C(c1cccc(Cl)c1)c1sc2cc(O)ccc2c1-c1ccccc1",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)c1ccc(Cl)c([N+](=O)[O-])c1.CCOCC.Cc1ccccc1.Cl.Cl[Sn]Cl.O.O.[Na+].[OH-]>>CC(=O)c1ccc(Cl)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC(C)(C)OC(=O)N1CCC(=O)CC1.CCO.Cl.NO.[Na+]>>CC(C)(C)OC(=O)N1CCC(=NO)CC1",
        "output": "86"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)/N=N/C(=O)OCC.O=C1CCCc2cc(O)ccc21.OCCC1CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C1CCCc2cc(OCCC3CC3)ccc21",
        "output": "478"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CNC.CO.Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(C=O)nc3)cc(N(C)C3CCOCC3)c2C)c(=O)[nH]1.[BH3-]C#N.[Na+]>>Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(CO)nc3)cc(N(C)C3CCOCC3)c2C)c(=O)[nH]1",
        "output": "745"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(C)=O.CO.O=C(Nc1cc(C(=O)O)cc(-c2ncco2)c1)OCc1ccccc1.O=C([O-])O.O=S(Cl)Cl.[Na+]>>COC(=O)c1cc(NC(=O)OCc2ccccc2)cc(-c2ncco2)c1",
        "output": "195"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc2c(Nc3ccc(C)c(OC(C)=O)c3)ncnc2cc1O.Cl.ClCc1ccncn1.[I-].[K+]>>COc1cc2c(Nc3ccc(C)c(OC(C)=O)c3)ncnc2cc1OCc1ccncn1",
        "output": "616"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCBr.CN(C)C=O.Cc1ccc(Oc2ccc(O)cc2)cc1.Cl.O=C([O-])[O-].[K+].[K+]>>C=CCOc1ccc(Oc2ccc(C)cc2)cc1",
        "output": "77"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O.O=CC1c2cc(CCCC(=O)O)ccc2-c2c(C(=O)O)cccc21.[BH4-].[Na+]>>O=C(O)CCCc1ccc2c(c1)C(CO)c1cccc(C(=O)O)c1-2",
        "output": "223"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCc1ccc(N)cc1.N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)O)(CC1)CC2>>CCCCc1ccc(NC(=O)C23CCC(NCC(=O)N4C[C@@H](F)C[C@H]4C#N)(CC2)CC3)cc1",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)N1CC=C(c2cc3c(cn2)OC2(C3)CC3(CCNCC3)C2)CC1.Clc1cnc(Cl)nc1>>CS(=O)(=O)N1CC=C(c2cc3c(cn2)OC2(C3)CC3(CCN(c4ncc(Cl)cn4)CC3)C2)CC1",
        "output": "36"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(C=O)CC1.CC(Cl)Cl.CCCNC1CCc2ccc(O)cc2C1.[Na+]>>CCCN(CC1CCN(C(=O)OC(C)(C)C)CC1)C1CCc2ccc(O)cc2C1",
        "output": "484"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.COc1ccc(C=O)cc1.[O-2].[Zn+2]>>COc1ccc(C=CC(C)=O)cc1",
        "output": "295"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COCCN(CCn1cc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)cn1)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>COCCNCCn1cc(-c2cc3nccc(Oc4ccc(NC(=O)NC5CC5)cc4F)c3s2)cn1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CCOC(C)=O.ClCCl.NCCCOc1ccc(-c2cnc3ccc(-c4cn(C(c5ccccc5)(c5ccccc5)c5ccccc5)nc4-c4ccc(F)cc4)cn23)cc1.O=C([O-])O.[Na+]>>CC(=O)NCCCOc1ccc(-c2cnc3ccc(-c4cn(C(c5ccccc5)(c5ccccc5)c5ccccc5)nc4-c4ccc(F)cc4)cn23)cc1",
        "output": "339"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cc2c(=O)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)oc2cc1C.NC1(c2ccc(-c3c(-c4ccccc4)oc4ccc(F)cc4c3=O)cc2)CCC1>>COc1cc2c(=O)c(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)oc2cc1C",
        "output": "793"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccccc4)oc4c(ccc5[nH]ncc54)c3=O)cc2)CCC1.CI.CN(C)C=O.[H-].[Na+]>>Cn1ncc2c3oc(-c4ccccc4)c(-c4ccc(C5(NC(=O)OC(C)(C)C)CCC5)cc4)c(=O)c3ccc21",
        "output": "229"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.CC(=O)O.Cc1cccc(F)c1C(=O)O.O.O=[N+]([O-])O.O=[N+]([O-])[O-].[Ag+]>>Cc1c(Br)ccc(F)c1C(=O)O",
        "output": "98"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCCC(S(=O)(=O)c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)C1.ClCCl.Cl[Pd]Cl.Nc1ncc(Br)nc1-c1nnc(-c2ccccc2)s1.O.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(C)OC(=O)N1CCCC(S(=O)(=O)c2ccc(-c3cnc(N)c(-c4nnc(-c5ccccc5)s4)n3)cc2)C1",
        "output": "937"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.OCc1ccccc1I.[Mn+2].[O-2]>>O=Cc1ccccc1I",
        "output": "179"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc2c(c1)CCC(Cc1ccc(OC)cc1NCc1ccc(OCCN3CCCCC3)cc1)C2.COc1ccc2c(c1)CCC(Cc1ccc(OC)cc1OS(=O)(=O)C(F)(F)F)C2.N#Cc1ccc(OCCN2CCCCC2)cc1.NCc1ccc(OCCN2CCCCC2)cc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Oc1ccc2c(c1)CCC(Cc1ccc(O)cc1NCc1ccc(OCCN3CCCCC3)cc1)C2",
        "output": "20"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCOCCOCCOCCOCCO1.C=CCBr.CC(C)(C)OC(=O)N1CCC2(CCC(O)CC2)CC1.CCOC(C)=O.Cc1ccccc1.[K+].[OH-]>>C=CCOC1CCC2(CC1)CCN(C(=O)OC(C)(C)C)CC2",
        "output": "120"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOc1ccc(Cl)cc1-c1cc(Cl)nc(N)n1.Nc1ccc(Cl)cc1>>CCOc1ccc(Cl)cc1-c1cc(Nc2ccc(Cl)cc2)nc(N)n1",
        "output": "161"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.CCOC(=O)CCN.CCOC(C)=O.Cl.N#Cc1ccc([N+](=O)[O-])c(F)c1>>CCOC(=O)CCNc1cc(C#N)ccc1[N+](=O)[O-]",
        "output": "572"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)Cc1nc2cc(S(=O)(=O)C(C)(C)C(=O)Cl)ccc2n1CC1CC1.CNC.Cl.ClCCl>>CN(C)C(=O)C(C)(C)S(=O)(=O)c1ccc2c(c1)nc(CC(C)(C)C)n2CC1CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COc1ccc(C(=O)Nc2ccc(C(C)(C)C#N)cc2)cc1OC.O=C([O-])[O-].OO.[K+].[K+]>>COc1ccc(C(=O)Nc2ccc(C(C)(C)C(N)=O)cc2)cc1OC",
        "output": "632"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)OC(=O)NCCCC[C@@H](CO)NC(=O)OCc1ccccc1.ClCCl.O=C([O-])O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>CC(C)(C)OC(=O)NCCCC[C@@H](C=O)NC(=O)OCc1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCNC.COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCBr>>CCCCCN(C)CCCCCOc1c(OC)ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc12",
        "output": "73"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Clc1ccc2c(Cl)ccnc2c1.N[C@H]1CC[C@@H](N)CC1.[Na+].[OH-]>>N[C@H]1CC[C@@H](Nc2ccnc3cc(Cl)ccc23)CC1",
        "output": "78"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(CCn1cc(-c2cc3nccc(Oc4ccc(N)cc4F)c3s2)cn1)C(=O)OC(C)(C)C.COc1ccccc1CC(=O)N=C=S.CS(=O)(=O)c1ccc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4F)c3s2)cc1>>COc1ccccc1CC(=O)NC(=S)Nc1ccc(Oc2ccnc3cc(-c4cnn(CCN(C)C(=O)OC(C)(C)C)c4)sc23)c(F)c1",
        "output": "961"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)c1cc(F)c2c(=O)[nH]ncc2c1.CN(C)C=O.Fc1cc(Br)ccc1CBr.O.[H-].[Na+]>>CC(C)(C)c1cc(F)c2c(=O)n(Cc3ccc(Br)cc3F)ncc2c1",
        "output": "635"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.C[Si](C)(C)CCO.Cl.ClCCl.O=C(O)C1CCCCC1>>C[Si](C)(C)CCOC(=O)C1CCCCC1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.COc1ccccc1CCCO.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>COc1ccccc1CCC=O",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CN(C)[C@@]12CNC[C@@H]1C2.ClCCCBr.O.O=C([O-])[O-].[K+].[K+]>>CN(C)[C@]12C[C@H]1CN(CCCCl)C2",
        "output": "73"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Nc1ccc(Sc2c(NCC(C)C)cc(C(=O)O)cc2S(N)(=O)=O)cc1.[Na+].[OH-].[Pt]>>CC(C)CNc1cc(C(=O)O)cc(S(N)(=O)=O)c1Sc1ccc(N)cc1",
        "output": "66"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Nc1cccc2cccnc12.O=[N+]([O-])c1cc(F)ccc1S(=O)(=O)Cl>>O=[N+]([O-])c1cc(F)ccc1S(=O)(=O)Nc1cccc2cccnc12",
        "output": "554"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(c2cccc(N)c2)C2CN(Cc3ccccc3)CC21.CS(=O)(=O)Cl.c1ccncc1>>CC1(c2cccc(NS(C)(=O)=O)c2)C2CN(Cc3ccccc3)CC21",
        "output": "194"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COC(=O)c1occc1C.Cl.O.[Na+].[OH-]>>Cc1ccoc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1CCN(CCc2ccc(N)cc2Cl)CC1.O=C(O)COc1ccc(C(F)(F)F)cc1Cl>>CC1CCN(CCc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3Cl)cc2Cl)CC1",
        "output": "365"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(O)C(Cc1ccc(Cl)cc1)c1cccc(C#N)c1.CCN(CC)CC.CS(=O)(=O)Cl.Cc1ccccc1>>CC(OS(C)(=O)=O)C(Cc1ccc(Cl)cc1)c1cccc(C#N)c1",
        "output": "0"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)n1cnc2c(N[C@H](CO)c3ccccc3)nc(Cl)nc21.CCCCCCN>>CCCCCCNc1nc(N[C@H](CO)c2ccccc2)c2ncn(C(C)C)c2n1",
        "output": "578"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)COc1cc(C)ccc1C(C)(C)C.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1ccc(C(C)(C)C)c(OCCO)c1",
        "output": "343"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc(C2(O)CCC(=O)CC2)cn1.O=C(CNC(=O)c1cc(F)cc(C(F)(F)F)c1)NC1CNC1>>Cc1ccc(C2(O)CCC(N3CC(NC(=O)CNC(=O)c4cc(F)cc(C(F)(F)F)c4)C3)CC2)cn1",
        "output": "187"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cc1nn(C(C)(C)C(N)=O)cc1[N+](=O)[O-].[H][H].[Pd]>>Cc1nn(C(C)(C)C(N)=O)cc1N",
        "output": "628"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1ncc(-c2ccccc2F)c2c1[nH]c1cc(C(=O)N3CCOCC3)ccc12.CO.O.[Li+].[OH-]>>O=C(O)c1ncc(-c2ccccc2F)c2c1[nH]c1cc(C(=O)N3CCOCC3)ccc12",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=C[C@H](OC)[C@@H](O)[C@H](C)/C=C(/C)CBr.CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.Cc1cccc(C)n1.ClCCl>>C=C[C@H](OC)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](C)/C=C(/C)CBr",
        "output": "839"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc(C=O)cc(OC)c1.N[C@H]1CCCc2ccccc21>>COc1cc(CN[C@H]2CCCc3ccccc32)cc(OC)c1",
        "output": "683"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCc1coc(-c2ccc3oc(-c4ccccc4)nc3c2)n1.Oc1ccc(CCCn2ccnc2)cc1>>c1ccc(-c2nc3cc(-c4nc(COc5ccc(CCCn6ccnc6)cc5)co4)ccc3o2)cc1",
        "output": "760"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCC1CC(OCc2ccccc2)CN1C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>C=CCC1CC(OCc2ccccc2)CN1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)N[C@H](C(=O)O)C(C)C.COC[C@@H]1CN[C@H](c2ncc(-c3cc4c5c(c3)OCc3cc(-c6cnc([C@@H]7C[C@H](C)CN7C(=O)[C@H](NC(=O)OC)c7ccccc7)[nH]6)cc(c3-5)OC4)[nH]2)C1.F[P-](F)(F)(F)(F)F>>COC[C@H]1C[C@@H](c2ncc(-c3cc4c5c(c3)OCc3cc(-c6cnc([C@@H]7C[C@H](C)CN7C(=O)[C@H](NC(=O)OC)c7ccccc7)[nH]6)cc(c3-5)OC4)[nH]2)N(C(=O)[C@@H](NC(=O)OC)C(C)C)C1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(N)C(=O)OCC(C)C.O=C(O)Cc1ccc(Br)cc1>>CCC(NC(=O)Cc1ccc(Br)cc1)C(=O)OCC(C)C",
        "output": "107"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CCCCOc1c(CN2C(=O)c3ccccc3C2=O)n(CCC(=O)OCC)c(=O)c2cc(Cl)c(Cl)cc12.Cl>>CCCCOc1c(CN2C(=O)c3ccccc3C2=O)n(CCC(=O)O)c(=O)c2cc(Cl)c(Cl)cc12",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "OCC1CCCc2ccccc21.Oc1cccc(-c2c(Cc3ccccc3)cnc3c(C(F)(F)F)cccc23)c1>>FC(F)(F)c1cccc2c(-c3cccc(OCC4CCCc5ccccc54)c3)c(Cc3ccccc3)cnc12",
        "output": "478"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Clc1ncccc1OCc1ccccc1.O=P(Cl)(Cl)Cl.O=c1cc(OCc2ccccc2)cc[nH]1>>Clc1cc(OCc2ccccc2)ccn1",
        "output": "100"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=C(O)c1ccc([N+](=O)[O-])cc1.O=S(=O)(O)O>>COC(=O)c1ccc([N+](=O)[O-])cc1",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)CC1.Clc1cc(Cl)nc(N2CCOCC2)n1.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCC(Oc2cc(Cl)nc(N3CCOCC3)n2)CC1",
        "output": "653"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CCc1ccc(N)cc1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[B-](F)(F)F.O=C(O)Cc1ccc(O)cc1>>CCc1ccc(NC(=O)Cc2ccc(O)cc2)cc1",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.CC#N.CCN(C(C)C)C(C)C.CCn1c(-c2ccc(NS(C)(=O)=O)cc2)c(C#N)c2ccc(OCCCl)cc21.O.[I-].[Na+]>>CCn1c(-c2ccc(NS(C)(=O)=O)cc2)c(C#N)c2ccc(OCCN3CCOCC3)cc21",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNC1.CCCCO.CCN(C(C)C)C(C)C.Clc1cc(Nc2ccc3[nH]ncc3c2)nc(Cl)n1>>Clc1cc(Nc2ccc3[nH]ncc3c2)nc(N2CCCC2)n1",
        "output": "36"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CN1CCCOc2ccc([N+](=O)[O-])cc21.[Pd]>>CN1CCCOc2ccc(N)cc21",
        "output": "202"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.CC#N.CCN(C(C)C)C(C)C.O=[N+]([O-])c1ccc(F)c(F)c1>>O=[N+]([O-])c1ccc(N2CCOCC2)c(F)c1",
        "output": "26"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1.Cl.Cl.O=C(CCCCBr)c1cccc2ccccc12>>COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCC(=O)c2cccc3ccccc23)CC1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=S(CCCNCCO)CCCC(F)(F)C(F)(F)F.Oc1ccc2c(c1)CCCC(c1ccccc1)=C2CCCCCCBr>>O=S(CCCN(CCO)CCCCCCC1=C(c2ccccc2)CCCc2cc(O)ccc21)CCCC(F)(F)C(F)(F)F",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.C[C@H](NC(=O)CNC(=O)CNC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1.[Pd]>>C[C@H](NC(=O)CNC(=O)CNC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COCCOC.Cn1ncc(Br)c1Nc1ccc(I)cc1.O.O=C([O-])[O-].OB(O)c1ccc(C(F)(F)F)cc1C(F)(F)F.[Cs+].[Cs+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cn1ncc(Br)c1Nc1ccc(-c2ccc(C(F)(F)F)cc2C(F)(F)F)cc1",
        "output": "855"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)c1n[nH]c([Si](C(C)C)(C(C)C)C(C)C)c1C.Cl.[Na+].[OH-]>>Cc1c(C(=O)O)n[nH]c1[Si](C(C)C)(C(C)C)C(C)C",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOc1ccccc1N1CCN(CCCCl)CC1.O.O=C1CCCc2c(O)cccc21>>CCOc1ccccc1N1CCN(CCCOc2cccc3c2CCCC3=O)CC1",
        "output": "74"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Cc1ccc(S(=O)(=O)O)cc1.Cc1cccc(C(=O)Nc2cn(C3CCCCO3)nc2C(=O)NCC(F)(F)F)n1.O>>Cc1cccc(C(=O)Nc2c[nH]nc2C(=O)NCC(F)(F)F)n1",
        "output": "689"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCCCCC1OCCO1.CN(C)C=O.COC(=O)c1ccc(O)cc1>>COC(=O)c1ccc(OCCCCC2OCCO2)cc1",
        "output": "385"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1ncc(Br)cc1NS(=O)(=O)c1ccc(O)c(C)c1.[K+]>>COc1ncc(B2OC(C)(C)C(C)(C)O2)cc1NS(=O)(=O)c1ccc(O)c(C)c1",
        "output": "943"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC1(C)OB(c2ccccc2C#N)OC1(C)C.CN1c2cc(Br)ccc2N(CC2CC2)S1(=O)=O.CO.O.O=C([O-])[O-].[Cs+].[Cs+].[Pd]>>CN1c2cc(-c3ccccc3C#N)ccc2N(CC2CC2)S1(=O)=O",
        "output": "933"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)c1nccnc1SCc1ccncc1.[Na+].[OH-]>>O=C(O)c1nccnc1SCc1ccncc1",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.CN(C)C=O.CN(Cc1ccccc1)[C@@H]1CCN(CCc2ccc(F)cc2)C[C@H]1COS(C)(=O)=O.[N-]=[N+]=[N-].[Na+]>>CN(Cc1ccccc1)[C@@H]1CCN(CCc2ccc(F)cc2)C[C@H]1CN=[N+]=[N-]",
        "output": "322"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CSCCN1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.COC(=O)c1cccc(-c2cnc(C(=O)CCc3ccc(-c4ccc(C=O)cc4)cc3)o2)n1.[Na+]>>COC(=O)c1cccc(-c2cnc(C(=O)CCc3ccc(-c4ccc(CN5CCSCC5)cc4)cc3)o2)n1",
        "output": "567"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C[C@H]1C[C@@H]1CNc1cc(-c2ncc([C@](C)(N)Cc3ccccc3)o2)cc(N(C)S(C)(=O)=O)n1.ClCCl.O=C1CCC(=O)N1Cl>>C[C@H]1C[C@@H]1CNc1cc(-c2ncc([C@](C)(N)Cc3ccccc3)o2)c(Cl)c(N(C)S(C)(=O)=O)n1",
        "output": "743"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO[C@@H](Cc1ccc(OCc2nc(-c3ccccc3)oc2C)cc1C)C(=O)OC.[Li+].[OH-]>>CCO[C@@H](Cc1ccc(OCc2nc(-c3ccccc3)oc2C)cc1C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COCCn1c(-c2ccc(C(C)C)cc2)nc2c(C#C[Si](C)(C)C)ccc(OC)c21.[Na+].[OH-]>>C#Cc1ccc(OC)c2c1nc(-c1ccc(C(C)C)cc1)n2CCOC",
        "output": "337"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Br.C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1.COc1cc2nc[nH]c(=O)c2cc1OC.Cl.Cl.c1ccncc1>>O=c1[nH]cnc2cc(O)c(O)cc12",
        "output": "19"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc2[nH]c(SCc3nccc(N4CCOCC4)c3F)nc2c1.ClCCl.N.O=C(OO)c1cccc(Cl)c1>>COc1ccc2[nH]c(S(=O)Cc3nccc(N4CCOCC4)c3F)nc2c1",
        "output": "595"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C1CCOC1.CC(C)(C)N.CCN=C=NCCCN(C)C.COC(=O)c1cccc(-c2nn(C3CCCCO3)c3ccc(-c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1.Cl.O.O.O.On1nnc2ccccc21.[Li+].[OH-]>>CC(C)(C)NC(=O)c1cccc(-c2nn(C3CCCCO3)c3ccc(-c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1",
        "output": "338"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)C1CNCC(c2ccc(OC(F)(F)F)cc2)C1.O=C(Cl)N1CCOCC1>>COC(=O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)N2CCOCC2)C1",
        "output": "258"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCN(C2CCNCC2)C1.COC(=O)c1nc(Cl)c(-c2cccc(C(F)(F)F)c2)cc1Cl.Cc1cc(-c2cccc(C(F)(F)F)c2)cnc1C(=O)O.O=C(O)c1nc(Cl)c(-c2cccc(C(F)(F)F)c2)cc1Cl>>O=C(c1nc(Cl)c(-c2cccc(C(F)(F)F)c2)cc1Cl)N1CCC(N2CCCC2)CC1",
        "output": "605"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.Cc1cc([N+](=O)[O-])c(O)c2c1CCC2=O.[C].[Pd]>>Cc1cc(N)c(O)c2c1CCC2=O",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(=O)OC(C)=O.CCN(CC)CC.Nc1cccc(-c2cc3[nH]c(=O)c4ccccc4n3n2)c1>>CC(=O)Nc1cccc(-c2cc3[nH]c(=O)c4ccccc4n3n2)c1",
        "output": "6"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1cc(-n2cc(NC(N)=O)c(C(N)=O)n2)ccc1-c1ccc(F)cc1O.NC(=O)CBr.O=C([O-])[O-].[K+].[K+]>>Cc1cc(-n2cc(NC(N)=O)c(C(N)=O)n2)ccc1-c1ccc(F)cc1OCC(N)=O",
        "output": "778"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC1CCCCN1.CS(C)=O.O.O=C([O-])[O-].O=Cc1cc(Br)ccc1F.[Na+].[Na+]>>CCC1CCCCN1c1ccc(Br)cc1C=O",
        "output": "868"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.Cc1ccccc1.O=C(Cl)c1ccccc1.OC1CCN(Cc2ccccc2F)CC1>>O=C(OC1CCN(Cc2ccccc2F)CC1)c1ccccc1",
        "output": "51"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(C)(N2CCC(=O)CC2)CC1.CCN(CC)CC.CO.N#CC[C@H]1CCCC[C@@H]1N.[BH3-]C#N.[Cl-].[Cl-].[Na+].[Zn+2]>>CC(C)(C)OC(=O)N1CCC(C)(N2CCC(N[C@H]3CCCC[C@@H]3CC#N)CC2)CC1",
        "output": "236"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C1(C(N)c2ccccc2)CCCC1.COc1cccc(-c2ccsc2C(=O)O)c1>>COc1cccc(-c2ccsc2C(=O)NC(c2ccccc2)C2(N(C)C)CCCC2)c1",
        "output": "950"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CCNc1ccc([N+](=O)[O-])cc1[N+](=O)[O-].CCO.Cl.O>>CCN(CC)CCNc1ccc([N+](=O)[O-])cc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCN(c1cc(Br)cc(C(=O)O)c1C)C1CCOCC1.CS(C)=O.Cc1cc(C(F)(F)F)c(CN)c(=O)[nH]1.Cl.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CCN(c1cc(Br)cc(C(=O)NCc2c(C(F)(F)F)cc(C)[nH]c2=O)c1C)C1CCOCC1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)Cc1ccc(OC)c(-c2ccc([N+](=O)[O-])cc2CN(CC)C(=O)OCc2ccccc2)c1.CCOC(C)=O.Cl.Cl[Sn]Cl>>CCOC(=O)Cc1ccc(OC)c(-c2ccc(N)cc2CN(CC)C(=O)OCc2ccccc2)c1",
        "output": "71"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.CN(C)C=O.NO.O.O=C(O)CCCCCCCNC(=O)C=C1c2ccccc2-c2ccccc21.[Cl-].[Na+]>>O=C(C=C1c2ccccc2-c2ccccc21)NCCCCCCCC(=O)NO",
        "output": "480"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(C)=O.O=C(O)c1ccc2nn[nH]c2c1.O=S(=O)(O)O.[Na+].[OH-]>>CCOC(=O)c1ccc2nn[nH]c2c1",
        "output": "33"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1ccc(F)c(F)c1Nc1ccc(I)cc1F.O=S(=O)(Cl)c1ccc(Cl)s1>>O=S(=O)(Nc1ccc(F)c(F)c1Nc1ccc(I)cc1F)c1ccc(Cl)s1",
        "output": "861"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.CN1CCNCC1.COc1cc(OC)nc(Cl)n1>>COc1cc(OC)nc(N2CCN(C)CC2)n1",
        "output": "36"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)[O-].O=C(CCl)NC1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cc3)c2)CC1.Oc1ccc(F)c(F)c1.[K+]>>O=C(COc1ccc(F)c(F)c1)NC1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cc3)c2)CC1",
        "output": "458"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)c1c(Cl)ccc(F)c1Cl.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Mg+2].[Na+].[OH-]>>CC(O)c1c(Cl)ccc(F)c1Cl",
        "output": "24"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)C1=C(c2ccccc2)c2ccc(OC)cc2C1(C)O.[Na+].[OH-]>>COc1ccc2c(c1)C(C)(O)C(C(=O)O)=C2c1ccccc1",
        "output": "122"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrBr.O=C(O)c1cc2ccccc2c(Br)c1O>>O=C(O)c1cc2ccccc2cc1O",
        "output": "350"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CN1CCC(O)CC1.Cc1ccccc1.O.O=[N+]([O-])c1ccc(F)c(C(F)(F)F)c1.[Br-]>>CN1CCC(Oc2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1",
        "output": "485"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrP(Br)Br.ClCCl.NC(=O)Nc1cccc(CO)c1>>NC(=O)Nc1cccc(CBr)c1",
        "output": "300"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(N(C(=O)OC(C)(C)C)c2cc(N)c(C(=O)O)cc2Br)CC1.CCS(=O)(=O)c1ccc(Cl)cc1CN.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Br)c(N(C(=O)OC(C)(C)C)C2CCN(C(=O)OC(C)(C)C)CC2)cc1N",
        "output": "753"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCC.CCOC(C)=O.COC(=O)[C@@H](NC(=O)c1ccc(-c2ccc(OC)c(F)c2)cc1N)C1CCCCC1.Cc1cc(C)c(N=C=O)c(C)c1.c1ccncc1>>COC(=O)[C@@H](NC(=O)c1ccc(-c2ccc(OC)c(F)c2)cc1NC(=O)Nc1c(C)cc(C)cc1C)C1CCCCC1",
        "output": "993"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.O=C(O)Cc1cc(OCc2ccccc2)cc(C(F)(F)F)c1>>CCOC(=O)Cc1cc(OCc2ccccc2)cc(C(F)(F)F)c1",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1nc(-c2ccccc2)[nH]c1C.COC(OC)N(C)C>>Cc1[nH]c(-c2ccccc2)nc1C(=O)C=CN(C)C",
        "output": "576"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.CC(C)=O.CC(C)O.CCC1CCCCC1O.CCOCC.O=S(=O)(O)O.O=[Cr](=O)=O>>CCC1CCCCC1=O",
        "output": "87"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1c1cc(C)nn1Cc1ccccc1.[Li+].[OH-]>>Cc1cc(N2C[C@H](S(=O)(=O)c3ccccc3Cl)C[C@H]2C(=O)O)n(Cc2ccccc2)n1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1COCCN1.CN(C)C=O.Cc1nnc2n1-c1sc(CC(=O)O)cc1C(c1ccccc1Cl)=NC2C.On1nnc2ccccc21>>Cc1nnc2n1-c1sc(CC(=O)N3CCOCC3)cc1C(c1ccccc1Cl)=NC2C",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)N1CCN(C(=O)Nc2cccc(C)c2)CC1.C[Si](C)(C)I.ClCCl>>Cc1cccc(NC(=O)N2CCNCC2)c1",
        "output": "283"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCCCCCCCCCCCC(=O)O.NCCCCc1ccnc2c1ccc1cccnc12.O.O=S(Cl)Cl.c1ccncc1>>CCCCCCCCCCCCCCCCCC(=O)NCCCCc1ccnc2c1ccc1cccnc12",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Oc1ccccc1C(=O)CCCCCCC(=O)O.CCN(CC)CC.Cl.NO>>CC(=O)Oc1ccccc1C(=O)CCCCCCC(=O)NO",
        "output": "480"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)CN(C(=O)Cc1ccc(Cl)cc1)c1ccccc1.Cl.O.[Na+].[OH-]>>O=C(O)CN(C(=O)Cc1ccc(Cl)cc1)c1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.NCCc1ccc(Cl)cc1.O=C(O)c1ccc2[nH]ccc2c1>>O=C(NCCc1ccc(Cl)cc1)c1ccc2[nH]ccc2c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.Cl.ClCCl.Nc1cccc(-c2nn(C3CCCCO3)c3ccc(-c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1.O=C(O)CC1CCCCC1>>O=C(CC1CCCCC1)Nc1cccc(-c2nn(C3CCCCO3)c3ccc(-c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)cc23)c1",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCC(O)[C@@H](C)N(c1cc(Cl)ccc1Cl)S(=O)(=O)c1ccc(Cl)cc1.CCO.[Pt]>>CCCC(O)[C@@H](C)N(c1cc(Cl)ccc1Cl)S(=O)(=O)c1ccc(Cl)cc1",
        "output": "116"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCCCC(CCBr)c1oc2cc(C(F)(F)F)ccc2c1C.CCOC(=O)COc1ccc(S)cc1C.O=C([O-])[O-].[Cs+].[Cs+]>>CCCCC(CCSc1ccc(OCC(=O)OCC)c(C)c1)c1oc2cc(C(F)(F)F)ccc2c1C",
        "output": "124"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.COc1ccnc(CSc2nc3c(C)c(OC(F)F)c(C)cc3[nH]2)c1OC.ClCCl.O=C(OO)c1cccc(Cl)c1.O=C([O-])[O-].O=S([O-])([O-])=S.[Na+].[Na+].[Na+].[Na+]>>COc1ccnc(CS(=O)c2nc3c(C)c(OC(F)F)c(C)cc3[nH]2)c1OC",
        "output": "595"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCC(N)C(=O)Nc1cn(C(C)(C)C(=O)OC)cn1.O=C(O)Cc1cc(F)cc(F)c1>>CCCC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(C(C)(C)C(=O)OC)cn1",
        "output": "133"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(-c2nc(-c3ccc4c(c3)OCO4)c(-c3ccccn3)[nH]2)cc1>>O=C(Cl)c1ccc(-c2nc(-c3ccc4c(c3)OCO4)c(-c3ccccn3)[nH]2)cc1",
        "output": "448"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NC(=O)c1ccc(Cl)nc1.O=C([O-])[O-].O=C1CCCc2cc(O)ccc21.[K+].[K+]>>NC(=O)c1ccc(Oc2ccc3c(c2)CCCC3=O)nc1",
        "output": "516"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)O.CC(C)[O-].CS(=O)(=O)c1ccc(Br)c(Cl)c1CBr.[Na+]>>CC(C)OCc1c(S(C)(=O)=O)ccc(Br)c1Cl",
        "output": "464"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COC(=O)c1cc(C)c(C(SCCCO[Si](C)(C)C(C)(C)C)c2c(F)ccc(F)c2F)cn1.O.[F-]>>COC(=O)c1cc(C)c(C(SCCCO)c2c(F)ccc(F)c2F)cn1",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CC(C)(C)C.CCN(CC)CC.Cc1ccccc1.Nc1cc(F)c([N+](=O)[O-])cc1Br.O.[Cu]I>>CC(C)(C)C#Cc1cc([N+](=O)[O-])c(F)cc1N",
        "output": "659"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cl.NC(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(F)cc1.O.O=C([O-])O.O=S(=O)(Cl)c1cccc2ccccc12.[Na+]>>O=S(=O)(NC(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(F)cc1)c1cccc2ccccc12",
        "output": "43"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1ccc(-c2cc(CCC=O)on2)cc1OC.ClCCl.[Na+].c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>COc1ccc(-c2cc(CCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)on2)cc1OC",
        "output": "484"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#Cc1ccc(C(=O)N2CCOCC2)cc1.CN(C)C(=O)c1ccc(C#C[Si](C)(C)C)cc1>>C#Cc1ccc(C(=O)N(C)C)cc1",
        "output": "337"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F.NCCc1ccc(CN2CCCC2)cc1.O=C(O)c1ccc(-c2ccc(Cl)cc2)cc1.O=C([O-])O.[Na+]>>O=C(NCCc1ccc(CN2CCCC2)cc1)c1ccc(-c2ccc(Cl)cc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Nc1ccccc1C(=O)O.O=Cc1ccnc2ccccc12>>O=C(O)c1ccccc1N=Cc1ccnc2ccccc12",
        "output": "329"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CC(C(=O)O)C2)nc1C(F)(F)F.NS(=O)(=O)Cc1ccc(Cl)cc1F>>CCOC(=O)c1cc(C#N)c(N2CC(C(=O)NS(=O)(=O)Cc3ccc(Cl)cc3F)C2)nc1C(F)(F)F",
        "output": "644"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OB(c2cc([N+](=O)[O-])ccc2F)OC1(C)C.N#Cc1c(F)cccc1Br>>N#Cc1c(F)cccc1-c1cc([N+](=O)[O-])ccc1F",
        "output": "933"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN1c2ncc(CCOc3ccnc4ccccc34)cc2C(=O)N(C)c2cccnc21.ClCCl.O=C(OO)c1cccc(Cl)c1>>CCN1c2ncc(CCOc3cc[n+]([O-])c4ccccc34)cc2C(=O)N(C)c2cccnc21",
        "output": "262"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Cl.ClCCl.N[C@@H](Cc1cc(F)cc(F)c1)c1ncc(N2C(=O)c3ccccc3C2=O)cc1Br>>CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)c1ncc(N2C(=O)c3ccccc3C2=O)cc1Br",
        "output": "631"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COc1cccnc1[N+](=O)[O-].[H][H].[Pd]>>COc1cccnc1N",
        "output": "457"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CS(C)=O.O=Cc1cccc(O)c1O.[H-].[H][H].[Na+]>>O=Cc1cccc(O)c1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)N(C)C.CC(C)(C)OC(=O)N1CCNCC1.CCN=C=NCCCN(C)C.Cl.O=C(O)c1cc(Cl)nc2c1c(I)nn2C1CCCCO1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCN(C(=O)c2cc(Cl)nc3c2c(I)nn3C2CCCCO2)CC1",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.CCOC(C)=O.Fc1cnc(Cl)nc1.O=C(NC1=N[C@@]2(c3ccc(F)s3)CNC[C@H]2CS1)c1ccccc1>>O=C(NC1=N[C@@]2(c3ccc(F)s3)CN(c3ncc(F)cn3)C[C@H]2CS1)c1ccccc1",
        "output": "36"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.CN(C)c1ccncc1.CO.COc1cc(/C=C(\\C#N)c2ccc3c(c2)OCO3)ccc1OCCCCCCCCCCCO.Cc1ccccc1.O=C(Cl)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1.c1ccncc1>>COc1cc(/C=C(\\C#N)c2ccc3c(c2)OCO3)ccc1OCCCCCCCCCCCOC(=O)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1",
        "output": "51"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCN(CCCO)CC1.COc1cc2ncnc(Cl)c2cc1O>>COc1cc2ncnc(Cl)c2cc1OCCCN1CCN(C)CC1",
        "output": "478"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.COc1ccc2c(=O)n(Cc3ccccc3)c(C(=O)O)c(-c3ccccc3)c2c1.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1c(-c2ccccc2)c2cc(OC)ccc2c(=O)n1Cc1ccccc1",
        "output": "415"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)C(Cc1ccc(OCCc2ccc(OS(C)(=O)=O)cc2)cc1)OC(C)C.O.[Li+].[OH-]>>CC(C)OC(Cc1ccc(OCCc2ccc(OS(C)(=O)=O)cc2)cc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CNc1ccc([Pd]Cl)c(C(C)(C)C)c1C(C)(C)C.COc1cc(C(F)(F)F)ccc1B(O)O.Clc1nccc2cc(SCc3ccccc3)cnc12.O.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>COc1cc(C(F)(F)F)ccc1-c1nccc2cc(SCc3ccccc3)cnc12",
        "output": "875"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(=O)Cl.CCCCCCCCCCOc1cnc(-c2ccc(C(C)O)cc2)nc1.Cl.O.c1ccncc1>>CCCCCCCCCCOc1cnc(-c2ccc(C(C)OC(=O)CC)cc2)nc1",
        "output": "126"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCN.CCN(CC)CC.CN(C)C=O.ClCCl.O.O=C(Cl)C(=O)Cl.O=C(O)Cc1ccc(B(O)O)cc1>>CCCCCCNC(=O)Cc1ccc(B(O)O)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CNOC.ClCCl.O.O=C(O)C1CC=CC1.O=C(n1ccnc1)n1ccnc1>>CON(C)C(=O)C1CC=CC1",
        "output": "54"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC2=NCCCN2CC1.COc1ncnc2c1CNCC2.ClCCl.N#Cc1cc(Cl)ccc1F>>COc1ncnc2c1CN(c1ccc(Cl)cc1C#N)CC2",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.Cc1cc(CCC(=O)c2sc(C)c3c2C[C@@H]2[C@H]3C2(C)C)cc(C)c1OCCCO.ClCCl>>Cc1cc(CCC(=O)c2sc(C)c3c2C[C@@H]2[C@H]3C2(C)C)cc(C)c1OCCCOS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1ccc2c(c1)CNCC2.ClCCCl.ClCCl.O=CCCCNC(=O)c1ccc(-c2ccccc2)cc1.[Na+]>>COc1ccc2c(c1)CN(CCCCNC(=O)c1ccc(-c3ccccc3)cc1)CC2",
        "output": "858"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)C1CCc2[nH]c3c(C(=O)O)cc(Br)cc3c2C1.ClCCCl.ClCCl.O.On1nnc2ccccc21.[NH4+].[OH-]>>CCOC(=O)C1CCc2[nH]c3c(C(N)=O)cc(Br)cc3c2C1",
        "output": "704"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)C(C)(C)Oc1ccc(OCCc2nc(-c3ccccc3)oc2C)cc1CNC(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)C(C)(C)Oc1ccc(OCCc2nc(-c3ccccc3)oc2C)cc1CN",
        "output": "793"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC1(C)CCCC(C)(C)N1.CCCCCC.Fc1ccc(Br)cc1F.O=C=O.[Li]CCCC>>O=C(O)c1c(Br)ccc(F)c1F",
        "output": "387"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cl[Pd]Cl.OC(c1ccc(Br)cn1)C(F)(F)F.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc(C(O)C(F)(F)F)nc2)OC1(C)C",
        "output": "943"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.CCN(CC)CC.CCOc1ccc2c(c1)C(C)(c1cccc(OC)c1)C(=O)N2S(=O)(=O)c1ccc(C(=O)NC(C)(C)C)cc1.ClCCl>>CCOc1ccc2c(c1)C(C)(c1cccc(O)c1)C(=O)N2S(=O)(=O)c1ccc(C(=O)NC(C)(C)C)cc1",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)C(C)(C)NC(=O)c1ccc2ccccc2c1OCCC(C)c1ccccc1.[Na+].[OH-]>>CC(CCOc1c(C(=O)NC(C)(C)C(=O)O)ccc2ccccc12)c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cl[Pd]Cl.Fc1ccc(Oc2ccc(Br)c(Cl)c2)cc1.[K+]>>CC1(C)OB(c2ccc(Oc3ccc(F)cc3)cc2Cl)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.CC(C)CC(=O)N1C[C@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(=O)Nc2ccccc21.CN(C)C=O.O.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)CC(=O)N1C[C@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(=O)N(Cc2ccccc2)c2ccccc21",
        "output": "688"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)c1cccn1S(=O)(=O)c1ccccc1.[K+].[OH-]>>O=C(O)c1cccn1S(=O)(=O)c1ccccc1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.O=C1CC(CO)C2(CC2)N1>>CS(=O)(=O)OCC1CC(=O)NC12CC2",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)CC1OB(O)c2cc(Oc3cnccn3)cc(C)c21.CO.Cl.O.[Li+].[OH-]>>Cc1cc(Oc2cnccn2)cc2c1C(CC(=O)O)OB2O",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1=CC(C)(C)Nc2ccc(-c3ccccc3O)c(C(=O)N3CCCC3)c21.CCOC(C)=O.CI.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>COc1ccccc1-c1ccc2c(c1C(=O)N1CCCC1)C(C)=CC(C)(C)N2",
        "output": "62"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.CCOC(=O)N1CCN(CCNc2ncnc3c2sc2nc(N4CCCC4)c4c(c23)CC(C)(C)CC4)CC1.[K+].[OH-]>>CC1(C)CCc2c(N3CCCC3)nc3sc4c(NCCN5CCNCC5)ncnc4c3c2C1",
        "output": "283"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)O.COc1ccc(Cn2ncc3ccc(OCCCCOS(=O)(=O)c4ccc(C)cc4)nc32)cc1.Clc1cccc(N2CCNCC2)c1Cl.O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(Cn2ncc3ccc(OCCCCN4CCN(c5cccc(Cl)c5Cl)CC4)nc32)cc1",
        "output": "429"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=[N+]([O-])c1cc2c(cc1CNCc1cscn1)c(Br)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1.[Zn]>>Nc1cc2c(cc1CNCc1cscn1)c(Br)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "588"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.COC(COc1ccc2c(c1)B(O)OC2)OC.Cl>>O=CCOc1ccc2c(c1)B(O)OC2",
        "output": "234"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Nc1ccc(C)cc1C.O=S(=O)(O)O.O=[N+]([O-])O>>CC(=O)Nc1cc([N+](=O)[O-])c(C)cc1C",
        "output": "21"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C=CC(C)CCC[C@@H](C)C(NC(=O)OC(C)(C)C)C(=O)OCC.CO.O.[Li+].[OH-]>>C=CC(C)CCC[C@@H](C)C(NC(=O)OC(C)(C)C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CC[C@H](N)CO.Cl.O.O=C(O)c1ccc(OCc2c(-c3ccc(F)cc3)noc2CO)nc1.Oc1cccc2[nH]nnc12>>CC[C@@H](CO)NC(=O)c1ccc(OCc2c(-c3ccc(F)cc3)noc2CO)nc1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNC1.CC(C)Oc1ccc(-c2nc(-c3cccc4c3CCC[C@@H]4N(CC(=O)O)C(=O)OC(C)(C)C)no2)cc1C#N.CN(C)C=O.ClCCCl.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CC(C)Oc1ccc(-c2nc(-c3cccc4c3CCC[C@@H]4N(CC(=O)N3CCCC3)C(=O)OC(C)(C)C)no2)cc1C#N",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#C[Si](C)(C)C.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.COC(=O)NC(C(=O)N1CCCC1c1ncc(-c2ccc(Br)cc2)[nH]1)C(C)C.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COC(=O)NC(C(=O)N1CCCC1c1ncc(-c2ccc(C#C[Si](C)(C)C)cc2)[nH]1)C(C)C",
        "output": "671"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.C[C@H](O)[C@@H](Nc1ccc(C#N)c(Cl)c1)C(=O)NNC(=O)c1ccc(S(C)(=O)=O)cc1.O.c1c[nH]cn1>>C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](Nc1ccc(C#N)c(Cl)c1)C(=O)NNC(=O)c1ccc(S(C)(=O)=O)cc1",
        "output": "193"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cc1ncc(C#N)c(Cl)c1I.Nc1cccc2[nH]ccc12.O=C([O-])O.[Na+]>>Cc1ncc(C#N)c(Nc2cccc3[nH]ccc23)c1I",
        "output": "115"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.Nc1cccc(F)c1>>CC(=O)Nc1cccc(F)c1",
        "output": "365"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cccc2c1CCC21NC(=O)N(CC(=O)OC(C)(C)C)C1=O.ClCCl.O=C(O)C(F)(F)F>>COc1cccc2c1CCC21NC(=O)N(CC(=O)O)C1=O",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)CCc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(O)cc3C)cc12.CCOC(C)=O.CCOP(=O)(OCC)C(F)(F)CCCBr.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CCc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCCCC(F)(F)P(=O)(OCC)OCC)cc3C)cc12",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN1CCCC1.Cc1cc(/C=C/c2cc3c(cc2CBr)C(C)(C)C(=O)CC3(C)C)ccc1C(=O)O.O.[Cl-].[Na+].c1cn[nH]c1>>Cc1cc(/C=C/c2cc3c(cc2Cn2cccn2)C(C)(C)C(=O)CC3(C)C)ccc1C(=O)O",
        "output": "635"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCCOc1ccc2ccccc2c1.CN(C)C=O.COC(=O)C(=O)c1ccc(O)cc1.[H-].[Na+]>>COC(=O)C(=O)c1ccc(OCCCCOc2ccc3ccccc3c2)cc1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)OC[C@H](CCO)O1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O>>CC1(C)OC[C@H](CCOS(C)(=O)=O)O1",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O=C(O)c1cncc(Br)c1.O=C([O-])O.O=S(Cl)Cl.[Na+]>>CCOC(=O)c1cncc(Br)c1",
        "output": "521"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC1(CC(=O)OC)OCCc2c1[nH]c1ccc(OC(F)(F)F)cc21.CCO.[Na+].[OH-]>>CCC1(CC(=O)O)OCCc2c1[nH]c1ccc(OC(F)(F)F)cc21",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1c(N)c(C#N)c(C)c(-c2ccccc2)c1Br.ClCCl.O.O=C([O-])[O-].[Na+].[Na+]>>Cc1c(C#N)c(N)c(O)c(Br)c1-c1ccccc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.Clc1ncc(Br)c(Cl)n1.NC1CCCC1>>Clc1ncc(Br)c(NC2CCCC2)n1",
        "output": "166"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(CC)(NCCCn1cnc(CCN)c1)c1ccccc1.O=C(Cl)c1ccccc1>>CCC(CC)(NCCCn1cnc(CCNC(=O)c2ccccc2)c1)c1ccccc1",
        "output": "271"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.Cc1nc(C)c(=O)n(CCO)c1C.c1ccncc1>>CC(=O)OCCn1c(C)c(C)nc(C)c1=O",
        "output": "254"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)OB(c2ccc(-c3cnc(N)nc3)c(F)c2)OC1(C)C.Nc1cnc(Oc2ccccc2Br)nc1>>Nc1cnc(Oc2ccccc2-c2ccc(-c3cnc(N)nc3)c(F)c2)nc1",
        "output": "933"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1ccc(O)cc1.CC(C)=O.ClCCCBr.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1ccc(OCCCCl)cc1",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)C(=O)Nc1cn(C2CCCCO2)nc1-c1nc2cc(F)c(NCCN(C)C)cc2[nH]1.ClCCl.O=C(O)C(F)(F)F>>CCN(CC)C(=O)Nc1c[nH]nc1-c1nc2cc(F)c(NCCN(C)C)cc2[nH]1",
        "output": "689"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)Cn1cc(-c2ccc(Cl)cc2)[nH]c1=O.[Li+].[OH-]>>O=C(O)Cn1cc(-c2ccc(Cl)cc2)[nH]c1=O",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.[N-]=[N+]=NCc1cc(=O)c(OCc2ccccc2)cn1Cc1ccccc1>>NCc1cc(=O)c(OCc2ccccc2)cn1Cc1ccccc1",
        "output": "89"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCNCC1.O=C(O)C(F)(F)F.O=C1CCN(c2nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc(N3CC4CCC(C3)O4)n2)CC1>>CN1CCN(C2CCN(c3nc(-c4ccc(NC(=O)Nc5ccncc5)cc4)nc(N4CC5CCC(C4)O5)n3)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COC(=O)[C@@H](C)[C@@H]1CCc2cc(OCCCBr)ccc21.Cc1cc(-c2nc(C(F)(F)F)ns2)ccc1O.O.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)[C@@H](C)[C@@H]1CCc2cc(OCCCOc3ccc(-c4nc(C(F)(F)F)ns4)cc3C)ccc21",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCN)c1nnc(C)n1-2.C[Si](C)(O)c1cccc(C(=O)O)c1.ClCCl>>COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCNC(=O)c1cccc([Si](C)(C)O)c1)c1nnc(C)n1-2",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(CC)CC.COCC(=O)Cl.Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1.O=C([O-])O.[Na+]>>COCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1",
        "output": "9"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CCOC(C)=O.CN(C)c1ccncc1.Cc1ccc(N)cc1Cl>>CC(=O)Nc1ccc(C)c(Cl)c1",
        "output": "6"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)Cc1cccc(NC(=O)NCC(=O)N2C(c3ccccc3)CCC2c2ccccc2O)c1>>O=C(O)Cc1cccc(NC(=O)NCC(=O)N2C(c3ccccc3)CCC2c2ccccc2O)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CI.O=c1c2ccccc2nc(-c2ccc3[nH]ccc3c2)n1-c1ccc(Cl)cc1.[H-].[Na+]>>Cn1ccc2cc(-c3nc4ccccc4c(=O)n3-c3ccc(Cl)cc3)ccc21",
        "output": "191"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCCc1cc(CCC=O)n(-c2ccc([N+](=O)[O-])cc2)n1.Fc1ccccc1N1CCNCC1.[Na+]>>CCCCc1cc(CCCN2CCN(c3ccccc3F)CC2)n(-c2ccc([N+](=O)[O-])cc2)n1",
        "output": "484"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C[Si]1(C)O[Si](C)(C)O[Si](C)(CCCO)O[Si](C)(C)O1.O=C(Cl)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.c1ccncc1>>C[Si]1(C)O[Si](C)(C)O[Si](C)(CCCOC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)O[Si](C)(C)O1",
        "output": "126"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cccc(C(C)=O)c1.Cc1c(F)cccc1C=O.[Na+].[OH-]>>COc1cccc(C(=O)/C=C/c2cccc(F)c2C)c1",
        "output": "656"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCC3CCCO3)CC2)c2ncnn12.CCOC(C)=O.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n([C@@H]2CC[C@@H](OCC3CCCO3)CC2)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O.OCCCBr>>C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCCCBr",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)OB(c2ccc(N)cc2)OC1(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.O=C(O)c1cn(Cc2ccccc2)cc(-c2ccc(F)cc2)c1=O.On1nnc2ccccc21>>CC1(C)OB(c2ccc(NC(=O)c3cn(Cc4ccccc4)cc(-c4ccc(F)cc4)c3=O)cc2)OC1(C)C",
        "output": "739"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cc(=O)[nH]nc1-c1ccc(O[Si](C)(C)C(C)(C)C)cc1.O>>Cc1cc(=O)n(C(=O)OC(C)(C)C)nc1-c1ccc(O[Si](C)(C)C(C)(C)C)cc1",
        "output": "841"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCCCCCCC/C=C\\CCCCCCCCOCC(CO)OCCCCCCCC/C=C\\CCCCCCCC.CN(C)C=O.CN(C)CCCC(=O)O.CN(C)c1ccncc1.Cl.ClCCl>>CCCCCCCC/C=C\\CCCCCCCCOCC(COC(=O)CCCN(C)C)OCCCCCCCC/C=C\\CCCCCCCC",
        "output": "47"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1CCN1CCC(NC(c2ccccc2)c2ccccc2)CC1>>NCCN1CCC(NC(c2ccccc2)c2ccccc2)CC1",
        "output": "242"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.N#Cc1ccccc1O.O=N[O-].O=S(=O)(O)O.O=[N+]([O-])[O-].[Na+].[Na+]>>N#Cc1cccc([N+](=O)[O-])c1O",
        "output": "21"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CNCCNC1=O.Cl.O=C(O)/C=C/c1ccc(Cl)c(Cl)c1>>CC1CN(C(=O)/C=C/c2ccc(Cl)c(Cl)c2)CCNC1=O",
        "output": "811"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrBr.CCOCCOc1cccc(Cc2ccccc2)n1.CC[N+](CC)(CC)CC.O=S([O-])[O-].[Br-].[Cl-].[K+].[K+].[Na+].[Na+].[OH-]>>CCOCCOc1ccc(Br)c(Cc2ccccc2)n1",
        "output": "292"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1ccccn1.CCN(CC)CC.CN(C)C=O.COC(=O)C(CC1CCCC1)c1ccc(I)cc1.Cl[Pd]Cl.[I-].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)C(CC1CCCC1)c1ccc(C#Cc2ccccn2)cc1",
        "output": "664"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCN(C)C.CCOC(=O)Cc1ccc(N)cc1F.CO.Cl.ClCCl.O=C(O)c1cc(OCc2cccc(Cl)c2)ccc1Cl>>CCOC(=O)Cc1ccc(NC(=O)c2cc(OCc3cccc(Cl)c3)ccc2Cl)cc1F",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc(-c2ccc(Nc3ccc(N4CCN(C)CC4)cc3)c3ncnn23)ccn1.Cl.O.c1ccncc1>>CN1CCN(c2ccc(Nc3ccc(-c4cc[nH]c(=O)c4)n4ncnc34)cc2)CC1",
        "output": "758"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CI.CN(C)C=O.Cc1cc(Br)c2[nH]ccc2c1.[H-].[Na+]>>Cc1cc(Br)c2c(ccn2C)c1",
        "output": "191"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.ClCCl.Nc1c[nH]c2ncc(Br)c(F)c12.O.O=C(O)CC1CC1.O=C1OCCN1P(=O)(Cl)N1CCOC1=O.[Li]O>>O=C(CC1CC1)Nc1c[nH]c2ncc(Br)c(F)c12",
        "output": "724"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc2c(c1)c1c(n2C)-c2cccnc2SC1.Cl.c1ccncc1>>Cn1c2c(c3cc(O)ccc31)CSc1ncccc1-2",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)O.CCN(CC)CC.Cl.Clc1ncc(Cl)c(Nc2ccccc2OCCN2CCOCC2)n1.Nc1ccc2c(c1)NC(=O)CCC2>>O=C1CCCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4OCCN4CCOCC4)n3)cc2N1",
        "output": "808"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CC#N.CCOC(C)=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1O.[Cs+].[Cs+]>>O=[N+]([O-])c1ccc(F)cc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1C[C@@H]2C[C@@H]2[C@H]1CN.O=C(O)c1cnc2ccccn12>>CC(C)(C)OC(=O)N1C[C@@H]2C[C@@H]2[C@H]1CNC(=O)c1cnc2ccccn12",
        "output": "697"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccc2c(c1)CNCCO2.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl>>CC(C)(C)OC(=O)N1CCOc2ccc(Br)cc2C1",
        "output": "867"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)O)cc3c2CCO)c1.ClCCl.F[P-](F)(F)(F)(F)F.Oc1c(F)c(F)c(F)c(F)c1F>>Cc1cc(C)cc(-c2[nH]c3sc(C(C)(C)C(=O)Oc4c(F)c(F)c(F)c(F)c4F)cc3c2CCO)c1",
        "output": "108"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[O-].CN(C)C1(c2ccccc2)CCC(O)CC1.CN(C)C=O.Fc1ccccc1CCl.[K+]>>CN(C)C1(c2ccccc2)CCC(OCc2ccccc2F)CC1",
        "output": "208"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CSc1c(CC(=O)OC(C)(C)C)cc(C)c2c1[nH]c1ccccc12.O=[N+]([O-])c1cccc(CBr)c1>>CSc1c(CC(=O)OC(C)(C)C)cc(C)c2c3ccccc3n(Cc3cccc([N+](=O)[O-])c3)c12",
        "output": "528"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.CCOC(=O)c1c(C)ncn1C.O.O=S([O-])O.[Na+].[Na+].[OH-]>>Cc1ncn(C)c1CO",
        "output": "286"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)CCN.CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.ClCCl.N#Cc1ccn2cc(-c3ccc(C(=O)O)cc3)nc2c1>>CC(C)(C)OC(=O)CCNC(=O)c1ccc(-c2cn3ccc(C#N)cc3n2)cc1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)[SiH2]OC(C)(C)c1cn(-c2ccc(N3CC(CN=[N+]=[N-])OC3=O)cc2F)cn1.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)[SiH2]OC(C)(C)c1cn(-c2ccc(N3CC(CN)OC3=O)cc2F)cn1",
        "output": "89"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)c1cc(Cl)ccn1.Cl.O.[BH4-].[Na+]>>OCc1cc(Cl)ccn1",
        "output": "711"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.CSc1ccc(C2=C(Oc3ccccc3)C(=O)CC2)cc1.ClCCl.O.O=S([O-])OO.[K+]>>CS(=O)(=O)c1ccc(C2=C(Oc3ccccc3)C(=O)CC2)cc1",
        "output": "730"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)CNC(=O)CCc1c(C)cc(-c2noc(-c3cc(C)c(CN(C)C(C)C)s3)n2)cc1CC.[Na+].[OH-]>>CCc1cc(-c2noc(-c3cc(C)c(CN(C)C(C)C)s3)n2)cc(C)c1CCC(=O)NCC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)CC(C)(C)C(=O)c1ccc(Br)cc1.O=[N+]([O-])O>>COC(=O)CC(C)(C)C(=O)c1ccc(Br)c([N+](=O)[O-])c1",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrC(Br)(Br)Br.CCOCC.OCCCCOCc1cc(Br)ccc1F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Fc1ccc(Br)cc1COCCCCBr",
        "output": "378"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCNC(=O)Nc1nc2cc(OCc3ccccc3)cc(C(=O)CC)c2s1.CS(=O)(=O)O.ClCCl>>CCNC(=O)Nc1nc2cc(O)cc(C(=O)CC)c2s1",
        "output": "23"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cl[Sn]Cl.Nc1cc(Cl)nc(Cl)c1[N+](=O)[O-]>>Nc1cc(Cl)nc(Cl)c1N",
        "output": "269"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cccc(F)c1NC(=O)[C@@H]1Cc2cccnc2N1C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C1CCOCC1.ClCCl.O=C(O)C(F)(F)F>>CN[C@@H](C)C(=O)N[C@H](C(=O)N1c2ncccc2C[C@H]1C(=O)Nc1c(C)cccc1F)C1CCOCC1",
        "output": "634"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCc1ccc(-c2ncc(C#N)c(O)n2)cc1.CCCCc1ccc(C(=N)N)cc1.CCO.CCOC=C(C#N)C(=O)OCC.CC[O-].Cl.O=P(Cl)(Cl)Cl.[Na+].[Na+].[OH-]>>CCCCc1ccc(-c2ncc(C#N)c(Cl)n2)cc1",
        "output": "25"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCc1cnc(N(CCc2csc(SC(C)(C)C(=O)OC(C)(C)C)n2)Cc2ccc(N3CCOCC3)cc2)nc1.ClCCl.O=C(O)C(F)(F)F>>CCc1cnc(N(CCc2csc(SC(C)(C)C(=O)O)n2)Cc2ccc(N3CCOCC3)cc2)nc1",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)O)c1.Clc1ccc2c(c1)CCNC2>>CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)N2CCc3cc(Cl)ccc3C2)c1",
        "output": "794"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCO)c1Oc1ccccc1OC.COc1cnc(Cl)nc1.O=C(O)CC(O)(CC(=O)O)C(=O)O.[H-].[Na+]>>CCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(OC)cn2)c1Oc1ccccc1OC",
        "output": "37"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)[C@@H]1CCCN1C(=O)C=Cc1ccccc1.Cl.O.[Na+].[OH-]>>O=C(O)[C@@H]1CCCN1C(=O)C=Cc1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.OCCCCCCCCCCCOc1ccccc1>>CS(=O)(=O)OCCCCCCCCCCCOc1ccccc1",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=CC(=O)Cl.CC(=O)N(C)C.Cc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1.Cl.O.O=C(O)CCCCCO.c1ccncc1>>C=CC(=O)OCCCCCC(=O)O",
        "output": "320"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccccn1.CCOCC.Cc1ccccc1.NC1CC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>c1ccc(NC2CC2)nc1",
        "output": "715"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)CCCOc1nc(Cl)c(C2CC2)cc1C#N.CS(C)=O.O.O=C([O-])[O-].OB1OCc2cc(O)ccc21.[Cs+].[Cs+]>>CC(=O)CCCOc1nc(Oc2ccc3c(c2)COB3O)c(C2CC2)cc1C#N",
        "output": "516"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)Cc1cc2ccc(F)cc2c(C2CCN(S(=O)(=O)c3ccccc3Cl)CC2)c1C.O.O.[Li+].[OH-]>>Cc1c(CC(=O)O)cc2ccc(F)cc2c1C1CCN(S(=O)(=O)c2ccccc2Cl)CC1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)N(C)C.CC(=O)c1ccc(F)cc1.Cc1cc(O)ccc1F.O.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1ccc(Oc2ccc(F)c(C)c2)cc1",
        "output": "564"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(N)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1cc(C(=O)O)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3c(=O)[nH][nH]c3c2)cc1.F[P-](F)(F)(F)(F)F>>Cc1cc(C(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3c(=O)[nH][nH]c3c2)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CN1CCC(=O)CC1.O=C1N[C@@H](Cc2ccc3[nH]ccc3c2)CO1>>CN1CC=C(c2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)CC1",
        "output": "607"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1cccc(N)c1.Cc1ccc(S(=O)(=O)O)cc1.O.OCCO.c1ccccc1>>CC1(c2cccc(N)c2)OCCO1",
        "output": "93"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)Cc1ccc(N2Cc3c(c(OCC)c4ccccc4c3OC(F)F)C2=O)c(Cl)c1.[Na+].[OH-]>>CCOc1c2c(c(OC(F)F)c3ccccc13)CN(c1ccc(CC(=O)O)cc1Cl)C2=O",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Nc1ccc(-c2ccc(S(=O)(=O)N3C(C(=O)O)CC4CCCC43)cc2)cc1.O=S(=O)(Cl)c1ccccc1.c1ccncc1>>O=C(O)C1CC2CCCC2N1S(=O)(=O)c1ccc(-c2ccc(NS(=O)(=O)c3ccccc3)cc2)cc1",
        "output": "68"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCCN.CN(C)C=O.CO.C[C@H]1[C@@H](c2ccccc2)OC(=O)CCC=CC[C@@H](CC(=O)O)C(=O)N1C.ClCCl>>CCOCCNC(=O)C[C@@H]1CC=CCCC(=O)O[C@H](c2ccccc2)[C@H](C)N(C)C1=O",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)O)c(OC)cc3C)c(F)c12.Cl.F[P-](F)(F)(F)(F)F.NC1(c2ccncn2)CC1.O>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5ccncn5)CC4)c(OC)cc3C)c(F)c12",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.Cl.Cl.O=C(O)C1CCCN(C2CCN(Cc3ccccc3)CC2)C1>>O=C(C1CCCN(C2CCN(Cc3ccccc3)CC2)C1)N1CCCCC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)CC1c2ccccc2CN1C(=O)OC(C)(C)C.[Na+].[OH-]>>CC(C)(C)OC(=O)N1Cc2ccccc2C1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cccc2c1OC1CCCC(O)C1O2.Cl.ClCCN1CCOCC1>>COc1cccc2c1OC1CCCC(OCCN3CCOCC3)C1O2",
        "output": "308"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Cc1cccc(N)c1C(=O)O>>Cc1cccc(NC(=O)OC(C)(C)C)c1C(=O)O",
        "output": "735"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CC(F)(F)C(=O)N2C.F[P-](F)(F)(F)(F)F.NCCN1CCCC1>>COc1cc(C(=O)NCCN2CCCC2)ccc1Nc1ncc2c(n1)N(C1CCCCC1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.C[C@@H](CN)Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12>>CC(=O)NC[C@H](C)Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NC12CC3CC(CC(C3)C1)C2.O=Cc1ccc2ccccc2n1>>c1ccc2nc(CNC34CC5CC(CC(C5)C3)C4)ccc2c1",
        "output": "775"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNCC1.CC(=O)N1CCC(CC(=O)c2ccc(F)cc2)CC1.O=C([O-])O.[Na+]>>CC(=O)N1CCC(CC(=O)c2ccc(N3CCCCC3)cc2)CC1",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1=CCC=CC1.CCOC(C)=O.Fc1ccc(Oc2cnc(Nc3cccc(OCc4ccccc4)c3)nc2)cc1.[OH-].[OH-].[Pd+2]>>Oc1cccc(Nc2ncc(Oc3ccc(F)cc3)cn2)c1",
        "output": "23"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(C(C)C)C(C)C.COCCCc1cc(CNC2CC2)c(Cl)cn1.Cl.ClCCl>>COCCCc1cc(CN(C(=O)OC(C)(C)C)C2CC2)c(Cl)cn1",
        "output": "694"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.C1CCOC1.O=C(O)C(c1c2ccccc2nn1-c1ccc(Cl)cc1)C1CCCCC1>>OCC(c1c2ccccc2nn1-c1ccc(Cl)cc1)C1CCCCC1",
        "output": "231"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.N#Cc1cc(Br)c2cc[nH]c2c1.O.OO.[Na+].[OH-]>>NC(=O)c1cc(Br)c2cc[nH]c2c1",
        "output": "180"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)N.CCCC(Nc1cnc(-c2ccc(C(F)(F)F)cc2)cn1)c1ccc(C(=O)NCCC(=O)OCC)cc1.CO.O=C=O>>CCCC(Nc1cnc(-c2ccc(C(F)(F)F)cc2)cn1)c1ccc(C(=O)NCCC(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC=O.NC(=O)c1ccc(F)c2c1CC(NCCCc1c[nH]c3ccc(Cl)cc13)CO2>>CCN(CCCc1c[nH]c2ccc(Cl)cc12)C1COc2c(F)ccc(C(N)=O)c2C1",
        "output": "484"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.Cl.NCCc1ccsc1.O=C(Cl)c1ccccc1>>O=C(NCCc1ccsc1)c1ccccc1",
        "output": "271"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.C[Si](C)(C)C#Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2)cc1.[F-]>>C#Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2)cc1",
        "output": "337"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCc1ccc(B(O)O)cc1.O=C1CN(c2ccc(-n3cc(-c4ccc(Cl)cc4Cl)nc3Cc3ccc(Br)cc3)cc2)S(=O)(=O)N1>>CCOC(=O)CCc1ccc(-c2ccc(Cc3nc(-c4ccc(Cl)cc4Cl)cn3-c3ccc(N4CC(=O)NS4(=O)=O)cc3)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CCC(N=[N+]=[N-])c1cc2ccc(F)cc2nc1Cl.CO.Cl[Sn]Cl.O.O>>C=CCC(N)c1cc2ccc(F)cc2nc1Cl",
        "output": "89"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc2nc(C)cc(C(=O)O)c2c1.Cl.NC1=NS(=O)(=O)Nc2cccc(OC[C@H]3CCCC[NH2+]3)c21>>Cc1ccc2nc(C)cc(C(=O)N3CCCC[C@@H]3COc3cccc4c3C(N)=NS(=O)(=O)N4)c2c1",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.NCCN1CC=CCC1.O=C(n1ccnc1)n1ccnc1.c1ccc(N2CCNCC2)cc1>>O=C(NCCN1CC=CCC1)N1CCN(c2ccccc2)CC1",
        "output": "734"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Cl.Cl.O=C([O-])[O-].O=[N+]([O-])c1cccnc1Cl.[K+].[K+].c1nc2c([nH]1)CCNC2>>O=[N+]([O-])c1cccnc1N1CCc2[nH]cnc2C1",
        "output": "220"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)CC(O)CC(C)(C)N1OC1CCCCC1.CCN(CC)CC.CCOCC.ClCCl.O=C(Cl)CCl>>CC1(C)CC(OC(=O)CCl)CC(C)(C)N1OC1CCCCC1",
        "output": "126"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CCOC(C)=O.ClCCl.O=C(O)CCCOc1cccc(CCCCCCOc2cc(C(=O)N3CCNCC3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O>>CC(=O)N1CCN(C(=O)c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc4c(c3)OCO4)c2)CC1",
        "output": "369"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(NC[C@H](O)CP(=O)(O)CC1CC=CCC1)c1ccc(Cl)c(Cl)c1.CCO.[Pd]>>CC(NC[C@H](O)CP(=O)(O)CC1CCCCC1)c1ccc(Cl)c(Cl)c1",
        "output": "143"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cc2nc(Cl)ccc2n1S(=O)(=O)c1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>O=S(=O)(c1ccccc1)n1c(CO)cc2nc(Cl)ccc21",
        "output": "546"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C[C@@H](C(=O)NN(CC(C)C)C(=O)[C@@H](C)O)[C@H](C/C=C/c1ccccc1)C(=O)NOC1CCCCO1.CO.Cc1ccc(S(=O)(=O)O)cc1>>CC(C)C[C@@H](C(=O)NN(CC(C)C)C(=O)[C@@H](C)O)[C@H](C/C=C/c1ccccc1)C(=O)NO",
        "output": "915"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COC(=O)c1cc(COc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)c(C)o1.COc1ccccc1Br.ClCCl.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)c1cc(COc2ccc(-c3ccccc3OC)cc2)c(C)o1",
        "output": "933"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COCCOC.Cl[Pd]Cl.Nc1nc(C(=O)N2Cc3ccccc3C2)c2cc(I)ccc2n1.O.O=C([O-])[O-].OCc1ccccc1B(O)O.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Nc1nc(C(=O)N2Cc3ccccc3C2)c2cc(-c3ccccc3CO)ccc2n1",
        "output": "855"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1CCN(C)C1=O.COc1ccc(CO)cc1.Cc1ccc(Br)cc1F.[Cl-].[H-].[NH4+].[Na+]>>COc1ccc(COc2cc(Br)ccc2C)cc1",
        "output": "485"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.Cc1cc(C(=O)O)c(S(=O)(=O)NC(C)(C)C)s1.Clc1ccccc1Cl.[Na+].[OH-]>>Cc1cc(C(=O)O)c(S(N)(=O)=O)s1",
        "output": "680"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(C)=O.Cc1ccccc1.O=C([O-])[O-].O=C1CCc2cc(Br)ccc21.OB(O)c1cccs1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C1CCc2cc(-c3cccs3)ccc21",
        "output": "903"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)S(=O)(=O)Cc1cccc(N)c1.CC(C)O.CCN(C(C)C)C(C)C.Clc1ncnc(Cl)n1>>CC(C)(C)S(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1",
        "output": "592"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)C(C)(C)c1cccc(Br)c1.[Li+].[OH-]>>CC(C)(C(=O)O)c1cccc(Br)c1",
        "output": "203"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.CN(C)C=O.O=C(CCl)c1ccc(Cl)cc1Cl>>O=C(CN1CCOCC1)c1ccc(Cl)cc1Cl",
        "output": "414"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NCCCNc1c([N+](=O)[O-])cnc2ccccc12.ClCCCl.[Pt]>>CC(C)(C)OC(=O)NCCCNc1c(N)cnc2ccccc12",
        "output": "269"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CCCOc1ccccc1CC#N.CCO.O.[Na+].[OH-]>>C=CCCOc1ccccc1CC(=O)O",
        "output": "259"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClC(Cl)Cl.ClCCl.O=S(=O)(Cl)CCCCl.c1ccc(C(c2ccccc2)N2CCNCC2)cc1>>O=S(=O)(CCCCl)N1CCN(C(c2ccccc2)c2ccccc2)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCN1.CCN(CC)CC.CO.N#Cc1cc(Cl)ccc1CBr>>N#Cc1cc(Cl)ccc1CN1CCOCC1",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.ClCCl.O=C(O)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1O.O=S(Cl)Cl>>O=C(Cl)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1O",
        "output": "3"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCN.CCN(CC)CC.Clc1nc(Cl)c2ncn(C3CCCC3)c2n1>>CCCCCNc1nc(Cl)nc2c1ncn2C1CCCC1",
        "output": "145"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)CCCCCCn1c2nc(=O)n(C)c(=O)c-2nc2cc(C)c(C)cc21.Cl.O.[Na+].[OH-]>>Cc1cc2nc3c(=O)n(C)c(=O)nc-3n(CCCCCCC(=O)O)c2cc1C",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCI.CCOC(C)=O.Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC1CC2CCCC(C1)N2.[H-].[Na+]>>CCN1C2CCCC1CC(NC(=O)c1c(C)nc3c(OCc4c(F)cccc4F)cccn13)C2",
        "output": "184"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COc1cccc(-c2cccc(C=O)c2)c1.[BH4-].[Na+]>>COc1cccc(-c2cccc(CO)c2)c1",
        "output": "356"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CI.CN(C)C=O.O.O=C([O-])[O-].Oc1cc(Cl)ccc1Br.[I-].[K+].[K+]>>COc1cc(Cl)ccc1Br",
        "output": "62"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)CNC(=O)c1cc(N2CCCN(C(=O)OC(C)(C)C)CC2)ccc1[N+](=O)[O-].O.[Pd]>>COC(=O)CNC(=O)c1cc(N2CCCN(C(=O)OC(C)(C)C)CC2)ccc1N",
        "output": "486"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1cnc(N2CCNCC2)c(C#N)c1.O=C(O)c1ccc(Br)nc1>>Cc1cnc(N2CCN(C(=O)c3ccc(Br)nc3)CC2)c(C#N)c1",
        "output": "256"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)(C)C(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)CN.Cl.O=C1OC(=O)c2ccccc21>>CC(C)(C)C(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)CN1C(=O)c2ccccc2C1=O",
        "output": "341"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)N.ClCCl.O=S(=O)(Cl)c1ccc(Br)cc1OC(F)(F)F>>CC(C)NS(=O)(=O)c1ccc(Br)cc1OC(F)(F)F",
        "output": "43"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)C1=Cc2cc(-c3ccc(OC(F)(F)F)cc3)ccc2S(=O)(=O)CC1.COCCOC.Cl>>O=C(O)C1=Cc2cc(-c3ccc(OC(F)(F)F)cc3)ccc2S(=O)(=O)CC1",
        "output": "58"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)Cc1cnn(C)c1.COc1ccc(N2CCN[C@@H](Cc3ccccc3)C2)cc1OC1CCC1>>COc1ccc(N2CCN(C(=O)Cc3cnn(C)c3)[C@@H](Cc3ccccc3)C2)cc1OC1CCC1",
        "output": "227"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc2[nH]ccc2c1.Cl.O.O=C1CCNCC1.[K+].[OH-]>>COc1ccc2[nH]cc(C3=CCNCC3)c2c1",
        "output": "607"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C#CCCO.CC(C)(C)OC(=O)CBr.CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.ClCCl.O.O=S(=O)([O-])[O-].[Na+].[OH-]>>C#CCCOCC(=O)OC(C)(C)C",
        "output": "669"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)O.CCOC(=O)N1CCC(Nc2nc3cccnc3n2Cc2ccco2)CC1.O.[K+].[OH-]>>c1coc(Cn2c(NC3CCNCC3)nc3cccnc32)c1",
        "output": "283"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cc2ncnc(N3CCN(C(=C[N+](=O)[O-])SC)CC3)c2cc1OC.NCc1ccncc1.c1ccncc1>>COc1cc2ncnc(N3CCN(C(=C[N+](=O)[O-])NCc4ccncc4)CC3)c2cc1OC",
        "output": "270"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(O)C#Cc1cc2c(cc1F)OCCn1c-2nc(C(N)=O)c1C(=O)O.CN1CCC(N)C1>>CN1CCC(NC(=O)c2c(C(N)=O)nc3n2CCOc2cc(F)c(C#CC(C)(C)O)cc2-3)C1",
        "output": "697"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Nc1ccc(C(=O)c2ccncc2)cc1[N+](=O)[O-].[H][H].[Pd]>>Nc1ccc(C(=O)c2ccncc2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCOCCO.CCOC(C)=O.Cl.ClCCNCCCl.Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1.O=C([O-])[O-].[K+].[K+]>>OC(c1ccc(N2CCNCC2)cc1)(C(F)(F)F)C(F)(F)F",
        "output": "640"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(C)=O.Cn1nc(C(C)(C)C)cc1N.O.O=C(Cl)OCC(Cl)(Cl)Cl.c1ccncc1>>Cn1nc(C(C)(C)C)cc1NC(=O)OCC(Cl)(Cl)Cl",
        "output": "700"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCBr.CCO.CCOc1c(O)cccc1F.ClCCl.[Na+].[OH-]>>CCOc1cccc(F)c1OCC",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)Cl.O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCNCC1>>CS(=O)(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1",
        "output": "584"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C/C(=C(\\F)CO)c1cc2c(c(Cl)c1OC(C)C)OC(C)(C)C=C2C(C)C.CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1>>C/C(=C(\\F)C=O)c1cc2c(c(Cl)c1OC(C)C)OC(C)(C)C=C2C(C)C",
        "output": "183"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCOC(C)=O.CCSc1ccccc1B1OC(C)(C)C(C)(C)O1.FC(F)(F)c1cn2cc(Br)ccc2n1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>CCSc1ccccc1-c1ccc2nc(C(F)(F)F)cn2c1",
        "output": "938"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrC1CCCC1.CN(C)C=O.COc1ccc(-c2nc(C(N)=O)c[nH]2)cc1O.O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(-c2nc(C(N)=O)c[nH]2)cc1OC1CCCC1",
        "output": "153"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(C=O)ccc21.ClCCl.NCC1CCCCC1.[Na+]>>CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CNCC3CCCCC3)ccc21",
        "output": "468"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)CNCC(O)c1ccccc1.CN(C)C=O.Cl.Clc1ccc2ncc(-c3cc4ccccc4o3)n2n1.[H-].[Na+]>>CC(C)(C)CNCC(Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1",
        "output": "407"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)C(O)c1ccc(Br)cc1.CC(C)OC(=O)N=NC(=O)OC(C)C.Oc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)C(Oc1ccccc1)c1ccc(Br)cc1",
        "output": "342"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(-c2nn(N)c(=O)c3ccccc23)cc1.O=C(Cl)CC12CC3CC(CC(C3)C1)C2>>COc1ccc(-c2nn(NC(=O)CC34CC5CC(CC(C5)C3)C4)c(=O)c3ccccc23)cc1",
        "output": "450"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CCOCC.CN(C)C(=O)[C@@H](N)Cc1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CN(C)C[C@@H](N)Cc1ccccc1",
        "output": "112"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCO.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=C(Cn1cncn1)c1ccc(Cl)cc1OC(F)F.OCC(O)CCl>>FC(F)Oc1cc(Cl)ccc1C1(Cn2cncn2)OCC(CCl)O1",
        "output": "93"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cn1cc(C=O)c2ccccc21.FC(F)(F)c1nnc2ccc(N3CCNCC3)nn12>>Cn1cc(CN2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)c2ccccc21",
        "output": "757"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(C)=O.Cc1cc2c(CO)cccn2n1.ClCCl.O=C(Cl)C(=O)Cl>>Cc1cc2c(C=O)cccn2n1",
        "output": "520"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)NCCC(=O)O.CC(C)N.CO.Cl.ClCCCl.ClCCl.O=C1CCCC1.On1nnc2ccccc21.[Na+]>>CC(C)NC1CCCC1",
        "output": "236"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.Cc1cc(-c2ccc(NC(=O)C(C)c3ccc(N)cc3)cc2)ccn1.ClCCCl.O=C([O-])[O-].[Na+].[Na+].[Na+]>>Cc1cc(-c2ccc(NC(=O)C(C)c3ccc(NC(C)C)cc3)cc2)ccn1",
        "output": "469"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.CC(O)(C(=O)O)C(F)(F)F.Cc1cc(N)ccc1S(=O)(=O)c1ccccc1.O.O=S(Cl)Cl>>Cc1cc(NC(=O)C(C)(O)C(F)(F)F)ccc1S(=O)(=O)c1ccccc1",
        "output": "365"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C(=O)O)c1ccc2c(c1)CCc1cccnc1O2.CCO.Cl.O=C([O-])O.[Na+]>>CCOC(=O)C(C)c1ccc2c(c1)CCc1cccnc1O2",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#C/C=C(\\CC)c1cccc(O[Si](C)(C)C(C)(C)C)c1.C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.[Cl-].[F-].[NH4+]>>C#C/C=C(\\CC)c1cccc(O)c1",
        "output": "754"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(Cl)ccc1-2.O.[Na+].[OH-]>>CN1Cc2c(C(=O)O)ncn2-c2ccc(Cl)cc2C1=O",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cccc(Nc2ccccc2C=O)c1C.Cl.NO.c1ccncc1>>Cc1cccc(Nc2ccccc2C=NO)c1C",
        "output": "30"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)c1ccc(S(=O)(=O)Cl)cc1.N>>CC(C)c1ccc(S(N)(=O)=O)cc1",
        "output": "245"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.C[C@H](O)C(F)(F)F.O=[N+]([O-])c1ccc(Cl)nc1.[H-].[Na+]>>C[C@H](Oc1ccc([N+](=O)[O-])cn1)C(F)(F)F",
        "output": "433"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.CS(=O)(=O)c1ccc(F)cc1.OCC[C@@H]1C[C@@H]1C1CCN(CC(F)(F)F)CC1.[H-].[Na+]>>CS(=O)(=O)c1ccc(OCC[C@@H]2C[C@@H]2C2CCN(CC(F)(F)F)CC2)cc1",
        "output": "485"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)CNCCNC1.CCN(CC)CC.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(Cl)C1CC2(CCN(C(=O)OCc3ccccc3)CC2)C1>>CC1(C)CNCCN(C(=O)C2CC3(CCN(C(=O)OCc4ccccc4)CC3)C2)C1",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COc1cc(CCN2CCCC2)ccc1[N+](=O)[O-].O=C[O-].[NH4+].[Pd]>>COc1cc(CCN2CCCC2)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCOc1cc(C)nc(C)c1C(=O)Nc1ccccc1.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.O=S([O-])O.[Na+]>>CCCOc1cc(C)[n+]([O-])c(C)c1C(=O)Nc1ccccc1",
        "output": "262"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCC(=O)Nc1cccc(C2CCNCC2)c1.CCn1c2ccccc2c2cc(C=O)ccc21>>CCC(=O)Nc1cccc(C2CCN(Cc3ccc4c(c3)c3ccccc3n4CC)CC2)c1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(Oc1cc(-c2cn(CC(=O)OC(C)(C)C)cn2)cnc1N)c1c(Cl)ccc(F)c1Cl.Cl.ClCCl>>CC(Oc1cc(-c2cn(CC(=O)O)cn2)cnc1N)c1c(Cl)ccc(F)c1Cl",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc(Cc2nc3c(C4CCCC4)noc3c(=O)[nH]2)cc1.O=S(=O)(O)Cl>>COc1ccc(Cc2nc3c(C4CCCC4)noc3c(=O)[nH]2)cc1S(=O)(=O)Cl",
        "output": "357"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(B2OC(C)(C)C(C)(C)O2)cc(Cl)c1O.O=C(c1cnc2ccc(Br)cc2c1N1CCC(CN2CCCC2)CC1)C1CC1>>COc1cc(-c2ccc3ncc(C(=O)C4CC4)c(N4CCC(CN5CCCC5)CC4)c3c2)cc(Cl)c1O",
        "output": "933"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCOC(C)=O.CS(C)=O.Cc1cc(F)ccc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>Cc1cc(N2CCN(C(=O)OC(C)(C)C)CC2)ccc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(=O)CC1.ClCCl.NC(CNC1CCOCC1)c1ccccc1.[Na+]>>CC(C)(C)OC(=O)N1CCC(NC(CNC2CCOCC2)c2ccccc2)CC1",
        "output": "589"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.ClCCl.O.O=C1Cc2cc([N+](=O)[O-])ccc2N1C1CC1.[Cl-].[Fe].[NH4+]>>Nc1ccc2c(c1)CC(=O)N2C1CC1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.ClCCl.NCCCCN1CCN(c2cccc(F)n2)CC1.O=S(=O)(Cl)CC1CCCCC1>>O=S(=O)(CC1CCCCC1)NCCCCN1CCN(c2cccc(F)n2)CC1",
        "output": "493"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CCN=C=NCCCN(C)C.CN(C)C(=O)c1cc(CCC(=O)O)ccc1NC(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1.CN(C)c1ccncc1.Cl.Oc1ccccc1>>CN(C)C(=O)c1cc(CCC(=O)Oc2ccccc2)ccc1NC(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1",
        "output": "108"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(CC(=O)O)S(=O)(=O)c1ccc(F)cc1.ClCCl.F[P-](F)(F)(F)(F)F.NCc1cccc(-c2ccc(C(F)(F)F)cn2)c1.O=S(=O)([O-])O.[K+]>>CN(CC(=O)NCc1cccc(-c2ccc(C(F)(F)F)cn2)c1)S(=O)(=O)c1ccc(F)cc1",
        "output": "599"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN(C)C=O.NC[C@H](O)CN1c2ccccc2CCc2ncccc21.O=S(=O)(Cl)c1ccc(OC(F)(F)F)cc1>>O=S(=O)(NC[C@H](O)CN1c2ccccc2CCc2ncccc21)c1ccc(OC(F)(F)F)cc1",
        "output": "43"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)Cc1ccc(OCCCC2CCN(c3ncc(Cl)cn3)CC2)cc1.O.O.[Li]O>>O=C(O)Cc1ccc(OCCCC2CCN(c3ncc(Cl)cn3)CC2)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)C1CCCC1Nc1ccc(Cl)cc1.CCOC(C)=O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OCC1CCCC1Nc1ccc(Cl)cc1",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCBr.CCCCCC1CCCC1O.CN(C)C=O.[H-].[Na+]>>C=CCOC1CCCC1CCCCC",
        "output": "120"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=NO)C(C)=NO.CC(=O)O.CN(C)C=O.O.O=C1NC(=O)C(=Cc2ccc(OCCC3CCCCC3)c(Cl)c2)S1.[BH4-].[Na+].[Na+].[OH-]>>O=C1NC(=O)C(Cc2ccc(OCCC3CCCCC3)c(Cl)c2)S1",
        "output": "762"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.C[C@H]1Cn2ncc(N3CC(N)CC3=O)c2CN1C(=O)OC(C)(C)C.O=Cc1ccccc1.[BH4-].[Na+]>>C[C@H]1Cn2ncc(N3CC(NCc4ccccc4)CC3=O)c2CN1C(=O)OC(C)(C)C",
        "output": "468"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.ClCCl.O.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl.c1ccc2c(c1)CCN2>>O=[N+]([O-])c1ccccc1S(=O)(=O)N1CCc2ccccc21",
        "output": "791"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1cncc(Br)c1.C#Cc1ccc(F)cc1.CC#N.CCN(CC)CC.CCOC(C)=O.[Cu]I.c1ccc([P]([Pd][P](c2ccccc2)(c2ccccc2)c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Fc1ccc(C#Cc2cncc(Br)c2)cc1",
        "output": "719"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C1=C(C(=O)N(CC(=O)O)C(C)C)SC2=N[C@@](C)(c3ccc(Cl)cc3)[C@@H](c3ccc(Cl)cc3)N21.C[C@@H]1CNCCN1C>>CC(C)C1=C(C(=O)N(CC(=O)N2CCN(C)[C@H](C)C2)C(C)C)SC2=N[C@@](C)(c3ccc(Cl)cc3)[C@@H](c3ccc(Cl)cc3)N21",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1c(-c2cccs2)nc2ccc(-c3cccc(CO[Si](C)(C)C(C)(C)C)c3)cn12.[F-]>>Cc1c(-c2cccs2)nc2ccc(-c3cccc(CO)c3)cn12",
        "output": "708"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CN(C)C=O.COCCOC.C[C@H]1COCCN1c1cc(CS(C)(=O)=O)nc(Cl)n1.Nc1cccc(B(O)O)c1.O.O=C([O-])[O-].[Na+].[Na+]>>C[C@H]1COCCN1c1cc(CS(C)(=O)=O)nc(-c2cccc(N)c2)n1",
        "output": "874"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(C)=O.CCCc1c(OCCCCl)ccc2c1OC(CCC(=O)OC)CC2.[I-].[Na+]>>CCCc1c(OCCCI)ccc2c1OC(CCC(=O)OC)CC2",
        "output": "97"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)C(C)(C)CNS(=O)(=O)c1cc(-c2ccc(S(=O)(=O)NC(C)(C)C)c(C(C)(C)C)c2)n(CC2CCCCC2)c1C.[Na+].[OH-]>>Cc1c(S(=O)(=O)NCC(C)(C)C(=O)O)cc(-c2ccc(S(=O)(=O)NC(C)(C)C)c(C(C)(C)C)c2)n1CC1CCCCC1",
        "output": "361"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CN(C)C=O.CN1CCCC1.CNc1nc(-n2cc(C(=O)O)c(=O)c3cc(F)c(F)c(Cl)c32)c(F)cc1F.Cl.Cl.NC1CNC1>>CNc1nc(-n2cc(C(=O)O)c(=O)c3cc(F)c(N4CC(N)C4)c(Cl)c32)c(F)cc1F",
        "output": "676"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)=CCBr.CCOCC.Cc1cc(N=CN(C)C)c(C)cc1O.[H-].[Na+]>>CC(C)=CCOc1cc(C)c(N=CN(C)C)cc1C",
        "output": "77"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)C1CN(Cc2ccc(-c3noc(COCC4(c5ccc(F)cc5)CCCCC4)n3)cc2)C1.CCOCC.O=C(O)C(F)(F)F>>O=C(O)C1CN(Cc2ccc(-c3noc(COCC4(c5ccc(F)cc5)CCCCC4)n3)cc2)C1",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCNCCOC.OCCCC#Cc1ccc2c(-c3ccc(F)cc3)csc2c1>>CCN(CCCC#Cc1ccc2c(-c3ccc(F)cc3)csc2c1)CCOC",
        "output": "371"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(=O)[O-].Cl.Nc1ccc(Cl)cc1C(=O)c1ccccc1Cl.O.O=N[O-].[N-]=[N+]=[N-].[Na+].[Na+].[Na+]>>[N-]=[N+]=Nc1ccc(Cl)cc1C(=O)c1ccccc1Cl",
        "output": "189"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C(Cl)OC(=O)NCC1(CC(=O)O)CCCCC1.CO.C[Si](C)(C)C=[N+]=[N-].c1ccccc1>>COC(=O)CC1(CNC(=O)OC(Cl)C(C)C)CCCCC1",
        "output": "195"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)CC(Nc2nccc(-c3ccc(CCC(=O)O)cc3)n2)CC(C)(C)N1.CO.N.O=S(Cl)Cl>>CC1(C)CC(Nc2nccc(-c3ccc(CCC(N)=O)cc3)n2)CC(C)(C)N1",
        "output": "313"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCCC.Clc1cccc(-c2onc3ccc(Br)cc23)c1.O=Cc1ccc(F)cc1.[Li]CCCC>>OC(c1ccc(F)cc1)c1ccc2noc(-c3cccc(Cl)c3)c2c1",
        "output": "379"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C)(C)Oc1ccc2c(ccn2CCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C)c1.Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1Cn1ccc2cc(OC(C)(C)C(=O)O)ccc21>>Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CCn1ccc2cc(OC(C)(C)C(=O)O)ccc21",
        "output": "192"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CNCCN1.CCC(C)=O.Fc1ccc(OCCBr)c(F)c1.O=C([O-])[O-].[K+].[K+]>>Fc1ccc(OCCN2CCNCC2)c(F)c1",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCP(CCCC)CCCC.CCOCC.COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1O.ClCCl.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.O=S1(=O)CCN(CCO)CC1>>COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCN1CCS(=O)(=O)CC1",
        "output": "478"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.CS(=O)(=O)OC[C@H](O)CCOc1cc(F)cc(Nc2ccc(I)cc2F)c1C(N)=O.NCCO>>NC(=O)c1c(Nc2ccc(I)cc2F)cc(F)cc1OCC[C@@H](O)CNCCO",
        "output": "559"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cl.O=C(O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(F)cc1.[Na][Na].c1ccc(C2CCNCC2)cc1>>O=C(O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(N2CCC(c3ccccc3)CC2)cc1",
        "output": "26"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(=O)c1c(NS(=O)(=O)c2ccc(F)cc2)sc2c1CCCC2.O.O.[Li+].[OH-]>>O=C(O)c1c(NS(=O)(=O)c2ccc(F)cc2)sc2c1CCCC2",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COc1ccc(NC(c2ccc(Cl)cc2CN=[N+]=[N-])C(F)F)cc1.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(NC(c2ccc(Cl)cc2CN)C(F)F)cc1",
        "output": "562"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCN)c1nnc(C)n1-2.ClCCl.O=C(O)c1cccc(O)c1O>>COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCNC(=O)c1cccc(O)c1O)c1nnc(C)n1-2",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)N.COc1ccc(-n2nc(C(=O)O)cc2-c2ccccn2)cn1>>COc1ccc(-n2nc(C(=O)NC(C)(C)C)cc2-c2ccccn2)cn1",
        "output": "816"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CC(C)O.CCN(CC)CC.Cc1c(Cl)nc2cc(F)cc(F)c2c1Cl>>Cc1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2cc(F)cc(F)c2c1Cl",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)c1nc(COCc2ccccc2)n(CCCc2ccccn2)c1Sc1cc(Cl)cc(Cl)c1.CCO.CO.Cl>>CC(C)c1nc(CO)n(CCCc2ccccn2)c1Sc1cc(Cl)cc(Cl)c1",
        "output": "178"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C=CCCCOC(=O)N[C@@H](CCCC)C(=O)OC.CCOC(C)=O.Cl.[Na+].[OH-]>>C=CCCCOC(=O)N[C@@H](CCCC)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCOCC.CO.Cl.Cn1c(=O)ccc2c3cnc(Nc4ccc(N5CCN(C(=O)OC(C)(C)C)CC5)cn4)nc3n(C3CCCC3)c21>>Cn1c(=O)ccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c21",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCc1ccccc1.CN(C)C=O.COc1ccc(-c2cccc(C#N)c2)n2nc(C3(CO)CC3)nc12.O.O=C([O-])O.[H-].[Na+].[Na+]>>COc1ccc(-c2cccc(C#N)c2)n2nc(C3(COCc4ccccc4)CC3)nc12",
        "output": "464"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CCC(=C(c1ccc(OC)cc1)c1ccc(OC)cc1)c1ccc(O)cc1.CCCCC(=O)c1ccc(OCC(=O)OCC)cc1.CCOC(=O)CBr.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)COc1ccc(C(CC)=C(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1",
        "output": "123"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COc1cc([N+](=O)[O-])ccc1OCc1ccccc1.O.O=C([O-])[O-].O=S([O-])S(=O)[O-].[Na+].[Na+].[Na+].[Na+]>>COc1cc(N)ccc1OCc1ccccc1",
        "output": "202"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CN1C(=O)C(F)(F)CN(C2CCCC2)c2nc(Cl)ncc21.Nc1cc(F)c(C(=O)O)cc1F.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2]>>CN1C(=O)C(F)(F)CN(C2CCCC2)c2nc(Nc3cc(F)c(C(=O)O)cc3F)ncc21",
        "output": "808"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1nnc2ccc(Cl)nn12.CN(C)C=O.NCCCN1CCC(OC(c2ccccc2)c2ccccc2)CC1>>CCOC(=O)c1nnc2ccc(NCCCN3CCC(OC(c4ccccc4)c4ccccc4)CC3)nn12",
        "output": "241"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COCCN1CCN(c2ccc(N)c(OC)c2)CC1.COc1ccc(-c2nc3ccccn3c2-c2ccnc(Cl)n2)cc1C(=O)Nc1c(F)cccc1F.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.N.OCC(F)(F)F>>COCCN1CCN(c2ccc(Nc3nccc(-c4c(-c5ccc(OC)c(C(=O)Nc6c(F)cccc6F)c5)nc5ccccn45)n3)c(OC)c2)CC1",
        "output": "808"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cl.N#Cc1ccc(Cl)cn1.[Pd]>>NCc1ccc(Cl)cn1",
        "output": "205"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[Si](C)(C)OCc1cccc(B(O)O)c1.COc1ccc2ccccc2c1-c1c(P(C2CCCCC2)C2CCCCC2)ccc2ccccc12.Cc1ccc(Br)cc1CNC(=O)OC(C)(C)C.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd+2]>>Cc1ccc(-c2cccc(CO[Si](C)(C)C(C)(C)C)c2)cc1CNC(=O)OC(C)(C)C",
        "output": "908"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCO.Cc1nc(Cl)cc(N(C)C)n1.N[C@@H]1CC[C@H](NC(=O)c2ccc(F)c(F)c2)CC1.O=C([O-])O.[Na+]>>Cc1nc(N[C@@H]2CC[C@H](NC(=O)c3ccc(F)c(F)c3)CC2)cc(N(C)C)n1",
        "output": "110"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OOC(=O)c1ccccc1C(=O)Cl.CC(O)CO.COC(C)(C)C.c1ccncc1>>CC(O)COC(=O)c1ccccc1C(=O)OOC(C)(C)C",
        "output": "51"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1cc2n(n1)-c1ccccc1CC2.CCOC(C)=O.COCCO[Al+]OCCOC.COCCO[AlH2-]OCCOC.Cl.O.[H-].[H-].[Na+].[Na+]>>OCc1cc2n(n1)-c1ccccc1CC2",
        "output": "391"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "B.C1CCOC1.CN(c1ccccc1)C(c1ccccc1)C(O)C(N)=O>>CN(c1ccccc1)C(c1ccccc1)C(O)CN",
        "output": "112"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CCO.CCOC(=O)C(C)C(C)SC(C)=O.CC[O-].[Na+]>>CCOC(=O)C(C)C(C)S",
        "output": "90"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.COC(=O)c1cccc([N+](=O)[O-])c1.[Pd]>>COC(=O)c1cccc(N)c1",
        "output": "481"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "OCCCCBr.Oc1ccc2ccccc2c1>>BrCCCCOc1ccc2ccccc2c1",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N(CC1CC1)[C@@H]1C[C@H]1c1ccc(F)c(C(=O)O)c1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.NC1CC(F)(F)C1.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N(CC1CC1)[C@@H]1C[C@H]1c1ccc(F)c(C(=O)NC2CC(F)(F)C2)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O.CO.CO.C[Si](C)(C)C#Cc1ccc(-c2cnco2)s1.[K+].[OH-]>>C#Cc1ccc(-c2cnco2)s1",
        "output": "337"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(COS(C)(=O)=O)CCC(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1.CN(C)C=O.[N-]=[N+]=[N-].[Na+]>>CC1(CN=[N+]=[N-])CCC(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1",
        "output": "322"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)COCc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1.O=C(O)C(F)(F)F.[Li+].[OH-]>>COc1cc(C)cc2cc(-c3c(COCC(=O)O)cn4ncnc(N)c34)sc12",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C[C@]1(c2cc(N)ccc2F)N=C(N)OC[C@@H]1F.O=C(O)c1ccc(C(F)F)cn1>>C[C@]1(c2cc(NC(=O)c3ccc(C(F)F)cn3)ccc2F)N=C(N)OC[C@@H]1F",
        "output": "985"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1cc(C)cc(-c2[nH]c3ccc([N+](=O)[O-])cc3c2CCN(CCCCc2ccc(NS(C)(=O)=O)cc2)Cc2ccccc2)c1.[H][H].[Ni]>>Cc1cc(C)cc(-c2[nH]c3ccc(N)cc3c2CCN(CCCCc2ccc(NS(C)(=O)=O)cc2)Cc2ccccc2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCC.CCN(CC)CC.CCOC(C)=O.COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1.ClCCl.N#N.OC[C@H]1O[C@@H](n2cnc3c(O)ncnc32)[C@H](OCc2ccccc2)[C@@H]1O.c1ccncc1>>COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(O)ncnc43)[C@H](OCc3ccccc3)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1",
        "output": "250"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C1COCCN1.N#N.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].O=C1CCc2cc(Br)ccc21.[Cs+].[Cs+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>O=C1CCc2cc(N3CCOCC3)ccc21",
        "output": "294"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.Cc1ccc(CO)cn1.c1ccncc1>>CC(=O)OCc1ccc(C)nc1",
        "output": "254"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.Cc1ccc(CCN)cc1>>CC(=O)NCCc1ccc(C)cc1",
        "output": "339"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1cccc2c(C(F)(F)C(F)(F)F)c(OC)ccc12.Cl.[Na+].[OH-]>>COc1ccc2c(C(=O)O)cccc2c1C(F)(F)C(F)(F)F",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "N[C@@H]1CC[C@@H](CCN2CCC(Oc3cc(F)c(F)cc3F)CC2)CC1.O=C(O)C1CCOCC1>>O=C(N[C@@H]1CC[C@@H](CCN2CCC(Oc3cc(F)c(F)cc3F)CC2)CC1)C1CCOCC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCCNCC1.Cc1cc(C#N)ccc1F>>Cc1cc(C#N)ccc1N1CCCN(C)CC1",
        "output": "26"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.O=C(O)c1cccc(/C=C/C(=O)c2cc(O)ccc2[N+](=O)[O-])c1>>CCOC(=O)c1cccc(/C=C/C(=O)c2cc(O)ccc2[N+](=O)[O-])c1",
        "output": "33"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc(Br)cc1C.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1cc(Br)ccc1CO",
        "output": "444"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.C=CCC/C(C)=C\\C(=O)OC.O.[Li+].[OH-]>>C=CCC/C(C)=C\\C(=O)O",
        "output": "58"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCP(=O)=O.CCN(CC)CC.CN(C)C=O.Cc1ccc(C(=O)O)cc1Nc1nccc(-c2cccnc2)n1.O=C([O-])O.[Na+].c1ccc(N2CCNCC2)nc1>>Cc1ccc(C(=O)N2CCN(c3ccccn3)CC2)cc1Nc1nccc(-c2cccnc2)n1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ncc(-c2cccc(C(F)(F)F)c2)cc1C.[Li+].[OH-]>>Cc1cc(-c2cccc(C(F)(F)F)c2)cnc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(Cl)C(=O)Cl.CCN(CC)CC.ClCCl.N[C@@H](CO)c1ccccc1>>CCC(Cl)C(=O)N[C@@H](CO)c1ccccc1",
        "output": "206"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)[C@@H]1CC[C@@H](CNc2cc(OC)ccc2[N+](=O)[O-])CC1.[H][H].[Pd]>>COC(=O)[C@@H]1CC[C@@H](CNc2cc(OC)ccc2N)CC1",
        "output": "202"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCO.C[C@@H]1CC[C@@H](O)CN1.C[C@@H]1CC[C@@H](O)C[N@@+]1([O-])Cc1ccccc1.[Pd]>>C[C@@H]1CC[C@@H](O)CN1C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COC(=O)COc1cc(C)cc2nc(Cl)c(Cc3ccc(Cl)cc3)c(C)c12.Cl.[Pd]>>COC(=O)COc1cc(C)cc2ncc(Cc3ccc(Cl)cc3)c(C)c12",
        "output": "40"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.COCCOC.Cc1cc(Cl)ccc1B(O)O.Nc1ccc(I)cc1.O.O=C([O-])[O-].[Na+].[Na+]>>Cc1cc(Cl)ccc1-c1ccc(N)cc1",
        "output": "855"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COc1ccc(CC(=O)O)cc1Br.CSC>>COc1ccc(CCO)cc1Br",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.Cc1cc(Cl)ncn1.ClCCl.Cl[Pd]Cl.O.O=C([O-])[O-].OB(O)c1ccccc1.[Na+].[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(-c2ccccc2)ncn1",
        "output": "884"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC(=O)N1CCC(NC(=O)Nc2ccc(C(=O)OC)cc2)CC1.CCO.[Na+].[OH-]>>CCC(=O)N1CCC(NC(=O)Nc2ccc(C(=O)O)cc2)CC1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNCC1.N#CC(CCBr)(c1ccccc1)c1ccccc1.O.O=C([O-])O.[I-].[K+].[K+]>>N#CC(CCN1CCCCC1)(c1ccccc1)c1ccccc1",
        "output": "73"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1ccc(CCC2(C3CCCC3)CC(=O)CC(=O)O2)cc1Cl.COC(=O)c1ccc(CCC2(C3CCCC3)CC(=O)CC(=O)O2)cc1F>>O=C1CC(=O)OC(CCc2ccc(C(=O)O)c(Cl)c2)(C2CCCC2)C1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Nc1ccc(O)cc1.CCCCP(CCCC)CCCC.CCOC(C)=O.N#Cc1ccc(N(CCO)CC(F)(F)F)cc1C(F)(F)F.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CC(C)(C)OC(=O)Nc1ccc(OCCN(CC(F)(F)F)c2ccc(C#N)c(C(F)(F)F)c2)cc1",
        "output": "478"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Fc1ccc(C2CCCN2)cc1.O=S(=O)(Cl)c1ccc(CO)cc1>>O=S(=O)(c1ccc(CO)cc1)N1CCCC1c1ccc(F)cc1",
        "output": "900"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CN1CC(=O)c2c(ccn2CCCCCl)S1(=O)=O.Cl.O=C([O-])O.O=C(c1ccc(F)cc1)C1CCNCC1.[I-].[Na+].[Na+]>>CN1CC(=O)c2c(ccn2CCCCN2CCC(C(=O)c3ccc(F)cc3)CC2)S1(=O)=O",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COc1ccc(C(=O)c2ccc(OC)cc2)cc1.Cl.NO.c1ccncc1>>COc1ccc(C(=NO)c2ccc(OC)cc2)cc1",
        "output": "190"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCO.CN(C)C=O.N#Cc1c([N+](=O)[O-])cccc1[N+](=O)[O-].[Na]>>CCCOc1cccc([N+](=O)[O-])c1C#N",
        "output": "499"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.NC1CCN(Cc2ccccc2)CC1.O=C(Cl)CCl>>O=C(CCl)NC1CCN(Cc2ccccc2)CC1",
        "output": "45"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1cnc(Cl)nc1.OCCCC1CCNCC1>>CCc1cnc(N2CCC(CCCO)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)=O.CC(C)C[C@H](N)CO.CCN(CC)CC.Cl.O>>CC(C)C[C@@H](CO)NC(=O)OC(C)(C)C",
        "output": "631"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1ccc(COc2nc(SC)ncc2C(=O)O)cc1Cl.F[P-](F)(F)(F)(F)F.NCc1ncccn1.O>>COc1ccc(COc2nc(SC)ncc2C(=O)NCc2ncccn2)cc1Cl",
        "output": "737"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)COCCOCCOCCOC.NN.O>>COCCOCCOCCOCC(=O)NN",
        "output": "164"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.Cc1ccccc1.Cc1nn(COCc2ccccc2)c2ccc(Br)cc12.[Li]CCCC>>Cc1nn(COCc2ccccc2)c2ccc(B(O)O)cc12",
        "output": "832"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCNc1cccnc1N1CCN(C(=O)c2ccc(C(=O)OC)cn2)CC1.NCCO>>CCNc1cccnc1N1CCN(C(=O)c2ccc(C(=O)NCCO)cn2)CC1",
        "output": "862"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CN(C)C=O.ClCCl.Cn1nc(C(F)(F)C(F)(F)F)c(C(F)(F)F)c1-n1cc(-c2ccc(Cl)c(C(=O)O)c2)nn1.NC1CC1.O=C(Cl)C(=O)Cl.O=C([O-])O.[Na+].c1ccncc1>>Cn1nc(C(F)(F)C(F)(F)F)c(C(F)(F)F)c1-n1cc(-c2ccc(Cl)c(C(=O)NC3CC3)c2)nn1",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCn1cc(-c2ccncc2)c(-c2cccc(N)c2F)n1.ClCCl.O=S(=O)(Cl)c1cccc(F)c1.c1ccncc1>>CCn1cc(-c2ccncc2)c(-c2cccc(NS(=O)(=O)c3cccc(F)c3)c2F)n1",
        "output": "68"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)C(=O)C1CCCNC1.N#Cc1ccc(F)c2ccccc12.c1ccncc1>>CCN(CC)C(=O)C1CCCN(c2ccc(C#N)c3ccccc23)C1",
        "output": "26"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)C=Cc1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)cc1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>CC(C)(C)OC(=O)NC1CCN(c2ccc(C=CC(=O)O)cc2)CC1",
        "output": "122"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN1CCOCC1.COC(=O)c1cccc(Oc2cnc(N)s2)c1.Cl.ClCCl.O=C(O)C(OC1CCOCC1)c1ccc(S(=O)(=O)C2CCCC2)nc1.On1nnc2ccccc21>>COC(=O)c1cccc(Oc2cnc(NC(=O)C(OC3CCOCC3)c3ccc(S(=O)(=O)C4CCCC4)nc3)s2)c1",
        "output": "681"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CSc1ccc(CC2C(C)=Cc3cc(F)ccc32)cc1.ClC(Cl)Cl.OO>>CC1=Cc2cc(F)ccc2C1Cc1ccc(S(C)=O)cc1",
        "output": "199"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1C[C@H](OCc2ccccc2)C[C@H]1CO.CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)N1C[C@H](OCc2ccccc2)C[C@H]1C=O",
        "output": "610"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCCN2CCCCC2=O)c1=O.C[C@@H](O)CN>>C[C@@H](O)CNC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCCN2CCCCC2=O)c1=O",
        "output": "498"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCCC(CO)C1.CC(C)=O.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)N1CCCC(COS(C)(=O)=O)C1",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Nc1cccc(S(F)(F)(F)(F)F)c1.O.O=C1CCC(=O)N1Br>>Nc1ccc(Br)c(S(F)(F)(F)(F)F)c1",
        "output": "4"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.Cc1c(O)ccc2c1NC(=O)CO2>>Cc1c(O)ccc2c1NCCO2",
        "output": "363"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.Cl.OCCOCc1ccccc1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCCOCc2ccccc2)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)[C@@H]1Cc2ccc([C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)OC(C)(C)C)C3)cc2CN1C(=O)OC(C)(C)C.C[C@@H](C(=O)N[C@H](C(=O)N1Cc2cc(C(=O)O)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C)N(C)C(=O)OC(C)(C)C>>CC(C)(C)OC(=O)N1Cc2cc([C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)OC(C)(C)C)C3)ccc2C[C@H]1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C(NC1CCCC1)c1noc(-c2ccc(C(F)(F)F)cc2)c1CO>>CS(=O)(=O)OCc1c(C(=O)NC2CCCC2)noc1-c1ccc(C(F)(F)F)cc1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cc1cc(-n2c(C)nc3ccccc32)ccc1[N+](=O)[O-].[Na+].[OH-]>>Cc1cc(-n2c(C)nc3ccccc32)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cc2sc(Br)cc2[nH]1.Cl>>O=C(O)c1cc2sc(Br)cc2[nH]1",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)NC(C)C.CCOCC.Fc1cc(Br)cc(Br)c1.O=C=O.[Li]CCCC>>O=C(O)c1c(F)cc(Br)cc1Br",
        "output": "387"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.ClCCl.Nc1cc2ccccc2cn1.O=C1CCC(=O)N1Br>>Nc1ncc2ccccc2c1Br",
        "output": "518"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.CCN(CC)CC.CCO.CCOC(=O)Cl.CNC.Cc1ccccc1.O=C(O)c1ccc2cnc(Br)cc2n1>>CN(C)C(=O)c1ccc2cnc(Br)cc2n1",
        "output": "605"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)O.CN(C)C=O.COC(=O)C1c2nc(S(C)(=O)=O)ncc2C(C)(C)N1C(=O)OCc1ccccc1.NC1CCOCC1>>COC(=O)C1c2nc(NC3CCOCC3)ncc2C(C)(C)N1C(=O)OCc1ccccc1",
        "output": "629"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.ClCCCl.O=C1COc2cnc(CO)cc2N1.[Mn+4].[O-2].[O-2]>>O=Cc1cc2c(cn1)OCC(=O)N2",
        "output": "263"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(O)c1ccnc(F)c1F.CN(C)C=O.CO.C[C@@H]1CC[C@@H](O)CN1C(=O)c1ccccc1-n1nccn1.[H-].[Na+]>>C[C@@H]1CC[C@@H](Oc2nccc(C(C)(C)O)c2F)CN1C(=O)c1ccccc1-n1nccn1",
        "output": "541"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "O.OCCOCCCl.[N-]=[N+]=[N-].[Na+]>>[N-]=[N+]=NCCOCCO",
        "output": "243"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[O-].CCOC(=O)/C(=N\\O[C@H]1CCNC1=O)c1csc(N)n1.CO.Cl.O.[Na+].[OH-]>>Nc1nc(/C(=N/O[C@H]2CCNC2=O)C(=O)O)cs1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(C)=O.CCOCC.COC(=O)c1ccc(CN(Cc2ccccc2)S(=O)(=O)c2ccc(Cl)cc2)nc1.Cl.O.[Na+].[OH-]>>O=C(O)c1ccc(CN(Cc2ccccc2)S(=O)(=O)c2ccc(Cl)cc2)nc1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.C[C@H]1COC[C@H](C)N1.ClCCl.O=Cc1cc(F)c(Cl)cc1F.[Na+]>>C[C@H]1COC[C@H](C)N1Cc1cc(F)c(Cl)cc1F",
        "output": "567"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Nc1cccc(C2CCN(CCCNc3nc(-c4ccc(Cl)cc4)c4ccccc4n3)CC2)c1.CCN(CC)CC.CO.[Pd]>>CC(=O)Nc1cccc(C2CCN(CCCNc3nc(-c4ccccc4)c4ccccc4n3)CC2)c1",
        "output": "253"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(=O)/C=C/c1ccc(N(C(=O)OC(C)(C)C)[C@@H]2CCNC2)nc1.COc1ccc(C=O)cc1.ClCCl.[Na+]>>CCOC(=O)/C=C/c1ccc(N(C(=O)OC(C)(C)C)[C@@H]2CCN(Cc3ccc(OC)cc3)C2)nc1",
        "output": "567"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)C=O.Cc1c(F)cc(-c2cccc(F)c2)cc1C(=O)O.ClCCl.Nc1c(F)ccc(O)c1F.O.O=C(Cl)C(=O)Cl.O=C([O-])[O-].[K+].[K+]>>Cc1c(F)cc(-c2cccc(F)c2)cc1C(=O)Nc1c(F)ccc(O)c1F",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.CO.CO[Na].Cl.N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O>>CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O",
        "output": "339"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.CC(C)(C)[O-].Cc1ccccc1.Clc1cc(N2CCOCC2)n2nc(-c3ccc(Br)cc3)cc2n1.O.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Na+].[Pd].[Pd]>>Clc1cc(N2CCOCC2)n2nc(-c3ccc(N4CCOCC4)cc3)cc2n1",
        "output": "294"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCC1CC1.CN(C)C=O.CNC(=O)c1cc(CCc2cnc(Nc3cn[nH]c3)nc2)c(F)c(OC)c1.O=C([O-])[O-].[Cs+].[Cs+]>>CNC(=O)c1cc(CCc2cnc(Nc3cnn(CC4CC4)c3)nc2)c(F)c(OC)c1",
        "output": "577"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)C(C#N)=NOC(N(C)C)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O=C(O)c1cccc(OCCc2ccc(Cl)cc2Cl)c1.c1cc(CN2CCNCC2)ccn1>>O=C(c1cccc(OCCc2ccc(Cl)cc2Cl)c1)N1CCN(Cc2ccncc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(CN2CCNCC2)Cn2cc([N+](=O)[O-])nc2O1.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Cc1ccc(CC(=O)O)cc1.Cl.Cl>>Cc1ccc(CC(=O)N2CCN(CC3(C)Cn4cc([N+](=O)[O-])nc4O3)CC2)cc1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccccc1.ClCCl>>Cc1c(CC(=O)O)c2cc(O)ccc2n1C(=O)c1ccccc1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)C#Cc1ccc(Br)cc1OC(F)(F)F.Cl.O.O=C=O.[Li]CCCC>>CC(C)C#Cc1ccc(C(=O)O)cc1OC(F)(F)F",
        "output": "654"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1C[C@H](NOCc2ccccc2)CC[C@H]1C(=O)NOCCNC(=O)OCc1ccccc1>>O=C(NCCONC(=O)[C@@H]1CC[C@@H](NOCc2ccccc2)CN1)OCc1ccccc1",
        "output": "634"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CCCN1CCC(N(Cc2cccc(OC)c2)c2ccc(C(=O)N(CC)CC)cc2)CC1.ClCCl.O=C([O-])O.O=C([O-])[O-].[Na+].[Na+].[Na+]>>CCCN1CCC(N(Cc2cccc(O)c2)c2ccc(C(=O)N(CC)CC)cc2)CC1",
        "output": "732"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)O)CC2)nc1CC.NS(=O)(=O)Cc1ccc(F)cc1F>>CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccc(F)cc3F)CC2)nc1CC",
        "output": "644"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.OCC1CN(Cc2ccccc2)CC1c1ccsc1>>O=CC1CN(Cc2ccccc2)CC1c1ccsc1",
        "output": "142"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CN.Cn1c(C(F)(F)F)nc2cc([N+](=O)[O-])c(Cl)nc21>>CNc1nc2c(cc1[N+](=O)[O-])nc(C(F)(F)F)n2C",
        "output": "70"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NC1CCc2cc(C#N)ccc2NC1=O.Cl.ClCCl>>N#Cc1ccc2c(c1)CCC(N)C(=O)N2",
        "output": "431"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CCN(CC)CC.CCOCc1nc2c(N)nc3cc(OCCCCCCN)ccc3c2n1CC(C)(C)NC(=O)NC(C)C.ClCCl>>CCOCc1nc2c(N)nc3cc(OCCCCCCNC(C)=O)ccc3c2n1CC(C)(C)NC(=O)NC(C)C",
        "output": "45"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC.CCOCC.COc1cc(OC)cc(P(=O)(c2cc(C)cc(C)c2)c2cc(C)cc(C)c2)c1.ClCCl.O=C([O-])[O-].O=C1CCC(=O)N1Br.[Na+].[Na+]>>COc1cc(OC)c(Br)c(P(=O)(c2cc(C)cc(C)c2)c2cc(C)cc(C)c2)c1",
        "output": "4"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCOc1cc(CO)cc(C2CC2)c1-c1ccc(F)cc1.Cc1ccccc1.[Mn+4].[O-2].[O-2]>>CCCOc1cc(C=O)cc(C2CC2)c1-c1ccc(F)cc1",
        "output": "179"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.Nc1cc(Br)cnc1O.O.O=C(Cl)c1ccc(C(F)(F)F)cc1.c1ccncc1>>O=C(Nc1cc(Br)cnc1O)c1ccc(C(F)(F)F)cc1",
        "output": "501"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)C[C@H](NC(=O)c1ccc(F)cc1N)C(=O)OC(C)(C)C.Cc1cc(C)c(N=C=O)c(C)c1.Cl.c1ccncc1>>Cc1cc(C)c(NC(=O)Nc2cc(F)ccc2C(=O)N[C@@H](CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(C)c1",
        "output": "993"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Cc1ccc(-c2ccccc2C#N)cc1.Cl.[Cl-].[Cl-].[N-]=[N+]=[N-].[Na+].[Zn+2]>>Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1",
        "output": "390"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOCc1nc2c(N)nc3ccccc3c2n1CCOCCN.ClCCl.O=C=Nc1ccccc1>>CCOCc1nc2c(N)nc3ccccc3c2n1CCOCCNC(=O)Nc1ccccc1",
        "output": "35"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)C1CCCN1Cc1ccccc1-c1ccc2nc(N)nc(C(=O)N3Cc4ccccc4C3)c2c1.[Na+].[OH-]>>Nc1nc(C(=O)N2Cc3ccccc3C2)c2cc(-c3ccccc3CN3CCCC3C(=O)O)ccc2n1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrC1CCCC1.CCO.COc1ccc(Br)cc1O.O.[Na+].[OH-]>>COc1ccc(Br)cc1OC1CCCC1",
        "output": "153"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>CC(=O)OC1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CN1CCC(O)CC1.O.O=[N+]([O-])c1cc(F)cc(F)c1.[H-].[Na+]>>CN1CCC(Oc2cc(F)cc([N+](=O)[O-])c2)CC1",
        "output": "485"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)c1c(C)nn(-c2ccccn2)c1C.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1nn(-c2ccccn2)c(C)c1CO",
        "output": "471"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCCCNc1nc(N)c(C(=O)C2CC2)s1.CCO.CCOCC.Cl>>NCCCNc1nc(N)c(C(=O)C2CC2)s1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N1CCN2c3ccccc3NC(=O)CC2C1.O.O=[N+]([O-])O>>CC(C)(C)OC(=O)N1CCN2c3ccc([N+](=O)[O-])cc3NC(=O)CC2C1",
        "output": "21"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1[C@@H](CCCC#C[Si](C)(C)C)COC1(C)C.CCCC[N+](CCCC)(CCCC)CCCC.CO.[F-]>>C#CCCC[C@H]1COC(C)(C)N1C(=O)OC(C)(C)C",
        "output": "337"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(-c2ccc(C=O)s2)s1.NC12CC3CC(CC(C3)C1)C2>>Cc1ccc(-c2ccc(CNC34CC5CC(CC(C5)C3)C4)s2)s1",
        "output": "691"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1ncc(Cl)nc1C(=O)Nc1cccc(Br)n1.OB(O)c1ccccc1>>Nc1ncc(Cl)nc1C(=O)Nc1cccc(-c2ccccc2)n1",
        "output": "869"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cccc(Nc2c([N+](=O)[O-])cc(C(=O)O)cc2S(N)(=O)=O)c1.NS(=O)(=O)c1cc(C(=O)O)cc([N+](=O)[O-])c1Nc1ccccc1>>COc1cccc(Nc2c(N)cc(C(=O)O)cc2S(N)(=O)=O)c1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O=C(O)C=Cc1ccccc1C(F)(F)F.O=S(=O)(O)O>>CCOC(=O)C=Cc1ccccc1C(F)(F)F",
        "output": "174"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nc1cccc(S(=O)(=O)NCCc2ccncc2)c1.O=C(O)c1cnn2c(C(F)(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12>>O=C(Nc1cccc(S(=O)(=O)NCCc2ccncc2)c1)c1cnn2c(C(F)(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12",
        "output": "969"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCI.Cc1c(-c2nc(-c3c(F)cccc3Cl)nn2C)csc1-c1ccc(O)cc1.[H-].[Na+]>>CCCOc1ccc(-c2scc(-c3nc(-c4c(F)cccc4Cl)nn3C)c2C)cc1",
        "output": "198"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-n2cccc2)cc1NC(=O)CC(=O)c1cccc(-n2ccnn2)c1.ClCCl.O=C(O)C(F)(F)F>>O=C1CC(c2cccc(-n3ccnn3)c2)=Nc2ccc(-n3cccc3)cc2N1",
        "output": "930"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(F)CN.CCN(CC)CC.CN(C)C=O.Cl.O.O=[N+]([O-])c1c(Cl)nc2ccccc2c1Cl>>CC(C)(F)CNc1c([N+](=O)[O-])c(Cl)nc2ccccc12",
        "output": "78"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)COC(=O)Cl.CCCCCCCCCCCCc1ccc(-c2nc(C3(C(=O)O)CC3)no2)cc1.CO.ClCCl.N>>CCCCCCCCCCCCc1ccc(-c2nc(C3(C(N)=O)CC3)no2)cc1",
        "output": "313"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)c1ccncc1.Cc1nn(-c2ccc(C#N)cc2)c(C)c1C(O)c1ccccc1.O.O=C(Cl)c1ccccc1.c1ccncc1>>Cc1nn(-c2ccc(C#N)cc2)c(C)c1C(OC(=O)c1ccccc1)c1ccccc1",
        "output": "51"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CCOCCCN(Cc1ccc(C(C)C)cc1)C(=O)CCc1ccc(OCc2ccccc2C(=O)OC)cc1.O.[Li+].[OH-]>>CCOCCCN(Cc1ccc(C(C)C)cc1)C(=O)CCc1ccc(OCc2ccccc2C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Cl.Fc1ccc(/C=C/c2nc(CCl)co2)c(F)c1.O.OCCCCc1ccc(O)cc1.[H-].[Na+]>>OCCCCc1ccc(OCc2coc(/C=C/c3ccc(F)cc3F)n2)cc1",
        "output": "760"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CO.N#Cc1ccc(CC=O)cc1.O=C1OCc2cc(CCN3CCNCC3)ccc21.[BH3-]C#N.[Na+]>>N#Cc1ccc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)cc1",
        "output": "484"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(N2CCN[C@@H](Cc3ccccc3)C2)cc1OC(C)C.O=C(O)Cc1nn[nH]n1>>COc1ccc(N2CCN(C(=O)Cc3nn[nH]n3)[C@@H](Cc3ccccc3)C2)cc1OC(C)C",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cc1cc(C)c(CCl)c(C)c1.O.[C-]#N.[Na+]>>Cc1cc(C)c(CC#N)c(C)c1",
        "output": "38"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=C([O-])O.O=Cc1ccc(Sc2ccc(Cl)c(Cl)c2)cc1Br.[BH4-].[Na+].[Na+]>>OCc1ccc(Sc2ccc(Cl)c(Cl)c2)cc1Br",
        "output": "356"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CCOC(=O)CC1=Cc2ccc(CCCC(=O)O)cc2Cc2ccccc21.CN1CCOCC1.Nc1ccccc1N.O>>CCOC(=O)CC1=Cc2ccc(CCCC(=O)Nc3ccccc3N)cc2Cc2ccccc21",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cc(-c2cccc(C(=O)CC(=O)OC(C)(C)C)c2)ccn1.Cc1cc(N)c(NC(=O)OC(C)(C)C)cc1C(F)(F)F>>Cc1cc(-c2cccc(C(=O)CC(=O)Nc3cc(C)c(C(F)(F)F)cc3NC(=O)OC(C)(C)C)c2)ccn1",
        "output": "929"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOc1cc(OCCCc2cn(-c3ccc(C(F)(F)F)cn3)nc2OCc2ccccc2)ccc1CCC(=O)OC.CO.Cl.[Na+].[OH-]>>CCOc1cc(OCCCc2cn(-c3ccc(C(F)(F)F)cn3)nc2OCc2ccccc2)ccc1CCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)CCSCc1cccc(C(=O)O)c1.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cc1cccc(CNc2cc(-c3cc(N4CCCCC4)ccc3N)ncn2)c1.Cl.ClCCl>>Cc1cccc(CNc2cc(-c3cc(N4CCCCC4)ccc3NC(=O)c3cccc(CSCCC(=O)OC(C)(C)C)c3)ncn2)c1",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCN(CC)CC1CCNC1.CCn1cc(C(=O)O)c(=O)c2cc(F)c(F)c(F)c21>>CCN(CC)CC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(CC)c3c2F)C1",
        "output": "676"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC#N.CN(C)c1ccncc1.Cc1cc(C)n(CC(=O)O)n1.OCc1ccccc1>>Cc1cc(C)n(CC(=O)OCc2ccccc2)n1",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CCC(=O)CC2)C1.CN.[BH3-]C#N.[Na+]>>CNC1CCC2(CC1)CCN(C(=O)OC(C)(C)C)C2",
        "output": "236"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCc1ccccc1OCCCCCSCC1COC(CCC(=O)OCC)(CCC(=O)OCC)S1.[Li+].[OH-]>>CCCc1ccccc1OCCCCCSCC1COC(CCC(=O)O)(CCC(=O)O)S1",
        "output": "255"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cn1nccc1Nc1nccc(-c2cc(F)[nH]c(=NN)c2)n1.F[P-](F)(F)(F)(F)F>>Cn1nccc1Nc1nccc(-c2cc(F)[nH]c(=NNC(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)OC(C)(C)C)c2)n1",
        "output": "459"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)C(=CC1(c2ccccc2C(F)(F)F)CCC1)OCC.O.[Na+].[OH-]>>CCOC(=CC1(c2ccccc2C(F)(F)F)CCC1)C(=O)O",
        "output": "122"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NC1CCN(S(=O)(=O)c2ccccc2)C1.CI.O.[H-].[Na+]>>CN(C(=O)OC(C)(C)C)C1CCN(S(=O)(=O)c2ccccc2)C1",
        "output": "803"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)COC(=O)Cl.CN[C@@H]1CN(C(=O)C2CCN(c3ccc(C#N)cn3)CC2)C[C@H]1c1ccc(Cl)cc1>>CC(C)COC(=O)N(C)[C@@H]1CN(C(=O)C2CCN(c3ccc(C#N)cn3)CC2)C[C@H]1c1ccc(Cl)cc1",
        "output": "219"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNc1ncc(-c2nc(N3CCOCC3)c3sc(CN4CCNCC4)c(C)c3n2)cn1.C[C@H](O)C(=O)O.O=C(O)C(F)(F)F>>CNc1ncc(-c2nc(N3CCOCC3)c3sc(CN4CCN(C(=O)[C@H](C)O)CC4)c(C)c3n2)cn1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CN.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cc(Br)cc([N+](=O)[O-])c1>>CNC(=O)c1cc(Br)cc([N+](=O)[O-])c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.O=C1CC(NC(=O)[C@@H]2CCC[C@@H]3CC=CC[C@H](NC(=O)c4ccccc4)C(=O)N32)C(O)O1.[Pd]>>O=C1CC(NC(=O)[C@@H]2CCC[C@@H]3CCCC[C@H](NC(=O)c4ccccc4)C(=O)N32)C(O)O1",
        "output": "143"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCCN1CCC(Cc2ccccc2)CC1.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Nc1ccc(I)cc1.[Cu]I>>Nc1ccc(C#CCCN2CCC(Cc3ccccc3)CC2)cc1",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(-c3cncc(NS(C)(=O)=O)c3)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12.N.O=C(O)C(F)(F)F>>Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cncc(NS(C)(=O)=O)c5)c34)n(-c3ccccc3)c(=O)c12",
        "output": "897"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)O[C@H](C(C)C)CN(C=O)C2.NO.[Na+].[OH-]>>CC(C)[C@@H]1CN(C=O)Cc2ccc(C(=O)NO)cc2O1",
        "output": "988"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.O=C1CN(c2ccc(N3C[C@H](CO)OC3=O)cc2F)CCN1CCF.c1ccncc1>>CS(=O)(=O)OC[C@H]1CN(c2ccc(N3CCN(CCF)C(=O)C3)c(F)c2)C(=O)O1",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Brc1c2ccccc2cc2ccccc12.C1COCCO1.CC(=O)[O-].CC(=O)[O-].Cc1ccc(B(O)O)c2ccccc12.Cc1ccccc1.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.O.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd+2]>>Cc1ccc(-c2c3ccccc3cc3ccccc23)c2ccccc12",
        "output": "837"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cl.Cl[Sn]Cl.O=C([O-])O.O=[N+]([O-])c1cc(C(F)(F)F)ccc1N1CCc2ccccc21.[Na+]>>Nc1cc(C(F)(F)F)ccc1N1CCc2ccccc21",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NCCCN.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1>>CC(C)(C)OC(=O)NCCCNC(=O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1",
        "output": "767"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C([O-])[O-].O=Cc1ccc(O)cc1F.[K+].[K+]>>O=Cc1ccc(OCc2ccccc2)cc1F",
        "output": "127"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCC(CCC(=O)O)(C(=O)OCC)C(=O)OCC.O=C(Cl)C(=O)Cl.c1ccccc1>>C=CCC(CCC(=O)Cl)(C(=O)OCC)C(=O)OCC",
        "output": "56"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2cccs2)nc2ccccc12)C1CCCCC1.O=C(O)CC(O)C(F)(F)F>>C[C@H](NC(=O)c1c(CN2CCN(C(=O)CC(O)C(F)(F)F)CC2)c(-c2cccs2)nc2ccccc12)C1CCCCC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.COc1cc(C#N)ccc1O.Cl.O.[Br-].[Li+]>>N#Cc1ccc(O)c(O)c1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)C(=O)c1ccc(OC/C=C/c2ccccc2)cc1.[Na+].[OH-]>>O=C(O)C(=O)c1ccc(OC/C=C/c2ccccc2)cc1",
        "output": "506"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CO.O=C(Cl)c1ccc(SCCCl)c([N+](=O)[O-])c1>>COC(=O)c1ccc(SCCCl)c([N+](=O)[O-])c1",
        "output": "51"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NC1Cc2cc(Br)ccc2N(Cc2ccccc2)C1.CO.N#N.O=C([O-])[O-].OB(O)c1ccc(F)cc1.[K+].[K+]>>CC(C)(C)OC(=O)NC1Cc2cc(-c3ccc(F)cc3)ccc2N(Cc2ccccc2)C1",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)CSCc1ccc(OC)c([N+](=O)[O-])n1.O=C([O-])[O-].[Na+].[Na+]>>COc1ccc(CSCC(=O)O)nc1[N+](=O)[O-]",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1cnn(-c2ncccc2C)c1C.C[Re](=O)(=O)=O.ClCCl.O.O=S([O-])([O-])=S.OO.[Na+].[Na+]>>COC(=O)c1cnn(-c2c(C)ccc[n+]2[O-])c1C",
        "output": "396"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(C(=O)NCCN(C(C)C)C(C)C)nc1.[Na+].[OH-]>>CC(C)N(CCNC(=O)c1ccc(C(=O)O)cn1)C(C)C",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)C1CC=C(c2c(-c3ccccc3)n(C)c3ccccc23)CC1.COC(=O)c1ccc(-c2c(-c3ccccc3)n(C)c3ccccc23)cc1>>Cn1c(-c2ccccc2)c(-c2ccc(C(=O)O)cc2)c2ccccc21",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)O)CC1.CNC1CCCC1>>CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)N(C)C2CCCC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)NC1CC[NH2+]CC1.CC(=O)[O-].CCN(CC)CC.CN(C)C=O.O=[N+]([O-])c1ccccc1F>>CC(=O)NC1CCN(c2ccccc2[N+](=O)[O-])CC1",
        "output": "26"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCCCN.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[B-](F)(F)F.O=C(O)CNC(=O)OCc1ccccc1>>CC(C)(C)OC(=O)NCCCNC(=O)CNC(=O)OCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cc1nc(CO[Si](C)(C)C(C)(C)C)ccc1[N+](=O)[O-].[Pd]>>Cc1nc(CO[Si](C)(C)C(C)(C)C)ccc1N",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCc1ccccc1.CN1CCCC1=O.O.O=C(O)c1cc(O)c2ccccc2n1.[H-].[Na+]>>O=C(OCc1ccccc1)c1cc(O)c2ccccc2n1",
        "output": "403"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)N1CCN(Cc2ccccc2)CC1.CO.Cl.Cl.O.[OH-].[OH-].[Pd+2]>>CC(C)(C)N1CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)c1ccncc1.COc1cc2nccc(Cl)c2cc1OC.Cc1ccc(O)c(C=O)c1.Clc1ccccc1Cl>>COc1cc2nccc(Oc3ccc(C)cc3C=O)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.O=c1[nH]c2ccncc2cc1-c1c(Cl)ccc([N+](=O)[O-])c1Cl>>Cn1c(=O)c(-c2c(Cl)ccc([N+](=O)[O-])c2Cl)cc2cnccc21",
        "output": "191"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN1CCOCC1.CCN=C=NCCCN(C)C.CNOC.Cl.Cl.ClCCl.O.O=C(O)c1ccccc1CCc1ccccc1.On1nnc2ccccc21>>CON(C)C(=O)c1ccccc1CCc1ccccc1",
        "output": "828"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCSc1cc(C(F)(F)F)n[nH]c1=O.O=P(Cl)(Cl)Cl>>CCSc1cc(C(F)(F)F)nnc1Cl",
        "output": "537"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1cccnc1.CC(C)(C)OC(=O)N[C@@H]1CCCNC1.CC(C)(C)[O-].COC(C)(C)C.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)OC(=O)N[C@@H]1CCCN(c2cccnc2)C1",
        "output": "597"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCCCCC.CCOC(C)=O.CO.COC(=O)c1ccc(C(C)(C)C)c([N+](=O)[O-])c1.[Zn]>>COC(=O)c1ccc(C(C)(C)C)c(N)c1",
        "output": "481"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(OCc1ccccc1)N1CCC(Nc2ccc3ncnc(Nc4ccc(F)c(Cl)c4)c3c2)CC1.O=C([O-])C(F)(F)F>>Fc1ccc(Nc2ncnc3ccc(NC4CCNCC4)cc23)cc1Cl",
        "output": "428"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cccc(C)n1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.OCCCl>>O=S(=O)(OCCCl)C(F)(F)F",
        "output": "582"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COC(=O)c1ccc2nc[nH]c(=O)c2c1.FC(F)(F)c1cccc(CBr)c1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc2ncn(Cc3cccc(C(F)(F)F)c3)c(=O)c2c1",
        "output": "389"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1nc(-c2ccc(C(F)(F)F)cc2)ccc1NC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>Cc1nc(-c2ccc(C(F)(F)F)cc2)ccc1N",
        "output": "877"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCOC(C)=O.CCc1ccc(N)cc1Br.CCc1ccc(Nc2nnc(Cc3ccnc(OC)c3)c3ccccc23)cc1Br.CO.Cl.N.c1ccc2cnncc2c1>>CCc1ccc(Nc2nnc(Cc3ccnc(O)c3)c3ccccc23)cc1Br",
        "output": "408"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(N2CCC(N3CCCC3C)C2)ccc1N.O=C(O)c1ccc2[nH]ccc2c1>>Cc1cc(N2CCC(N3CCCC3C)C2)ccc1NC(=O)c1ccc2[nH]ccc2c1",
        "output": "50"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc(C(=O)NC(C)c2ccc(OCC(F)(F)F)nc2)cc(N)n1.O=C(Cl)C1CCC1>>Cc1cc(C(=O)NC(C)c2ccc(OCC(F)(F)F)nc2)cc(NC(=O)C2CCC2)n1",
        "output": "332"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COC(=O)C[C@@H]1COc2cc(N)ccc21.Cc1c(C=O)cccc1-n1c([C@H]2CCCO2)nc2cc(F)ccc21.[Na+].[Na+].[OH-]>>COC(=O)C[C@@H]1COc2cc(NCc3cccc(-n4c([C@H]5CCCO5)nc5cc(F)ccc54)c3C)ccc21",
        "output": "359"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=CCN1CCCc2cc(C(=O)O)ccc21.CN.O=C(c1ncc[nH]1)c1ncc[nH]1>>C=CCN1CCCc2cc(C(=O)NC)ccc21",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.COC(=O)c1ccc(NC(c2sc3cc(C(F)(F)F)cnc3c2C)C2CCCCC2)cc1.[Na+].[OH-]>>Cc1c(C(Nc2ccc(C(=O)O)cc2)C2CCCCC2)sc2cc(C(F)(F)F)cnc12",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O.O=C1CC2(CN1)CC(=O)c1cc(Cl)ccc12.[BH4-].[Na+].[Na+].[OH-]>>O=C1CC2(CN1)CC(O)c1cc(Cl)ccc12",
        "output": "24"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.COCc1cccc2cccc(CO)c12.ClCCl>>COCc1cccc2cccc(C=O)c12",
        "output": "179"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)CCN.F[P-](F)(F)(F)(F)F.O>>CC(=O)N1c2ccc(-c3ccc(C(=O)NCCN(C)C)cc3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cl.Nc1nc(-c2ccncc2)c(-c2ccncc2)cc1[N+](=O)[O-].[Fe]>>Nc1cc(-c2ccncc2)c(-c2ccncc2)nc1N",
        "output": "269"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cc1nnc[nH]1.FC(F)Oc1ccc(N2CCN[C@@H](Cc3ccccc3)C2)cc1OC1CCC1>>O=C(Cc1nnc[nH]1)N1CCN(c2ccc(OC(F)F)c(OC3CCC3)c2)C[C@@H]1Cc1ccccc1",
        "output": "494"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1nc2cc[nH]c(=O)c2c2cc(Br)ccc12.CN(C)C=O.ClCCl.Cl[Pd]Cl.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)c1nc2cc[nH]c(=O)c2c2cc(-c3cnn(C)c3)ccc12",
        "output": "971"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C1CCCN(C(=O)c2ccsc2)C1.CCOC(=O)C1CCCNC1.O=C(O)C=Cc1cccs1>>CCOC(=O)C1CCCN(C(=O)C=Cc2cccs2)C1",
        "output": "517"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)CC[C@H](NC(=O)c1cc(OCC(=O)C(C)(C)C)n(-c2ccccc2)n1)C(=O)O.CCN1CCOCC1.CCOC(=O)C(C#N)=NOC(N(C)C)=[N+](C)C.CCOC(C)=O.CN(C)C=O.F[B-](F)(F)F.O=C(OCc1ccccc1)N1CCNCC1>>CC(C)(C)OC(=O)CC[C@H](NC(=O)c1cc(OCC(=O)C(C)(C)C)n(-c2ccccc2)n1)C(=O)N1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOc1c(F)cc(Cl)c([N+](=O)[O-])c1Br.Cl.Cl[Sn]Cl.O>>CCOc1c(F)cc(Cl)c(N)c1Br",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1ccc(Oc2cc(Cl)ncn2)cc1C.Cl.Cl.O=c1[nH]c2ncccc2n1C1CCNCC1>>Cc1ccc(Oc2cc(N3CCC(n4c(=O)[nH]c5ncccc54)CC3)ncn2)cc1C",
        "output": "162"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCSc1c(C(=O)N2CCC(c3ccccc3C(F)(F)F)C2)cnn1-c1ccc(C(=O)OC)cc1.CO.[Na+].[OH-]>>CCCSc1c(C(=O)N2CCC(c3ccccc3C(F)(F)F)C2)cnn1-c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C[C@H](CO)Nc1nc(Cl)ncc1-c1cccs1.Cc1ccc(NC(=O)N=S(C)(=O)c2ccc(N)cc2)cc1>>Cc1ccc(NC(=O)N=S(C)(=O)c2ccc(Nc3ncc(-c4cccs4)c(N[C@H](C)CO)n3)cc2)cc1",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.NCC(O)c1cccnc1.O=C(O)c1cc2cc(Cl)ncc2[nH]1.On1nnc2ccccc21>>O=C(NCC(O)c1cccnc1)c1cc2cc(Cl)ncc2[nH]1",
        "output": "137"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(=O)CC1Cc2ccc(OCCCNc3cc(N)ccn3)cc2Cc2ccccc21.O.O=C(O)C(F)(F)F.[Li+].[OH-]>>Nc1ccnc(NCCCOc2ccc3c(c2)Cc2ccccc2C(CC(=O)O)C3)c1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)Cc1csc(-c2ccc(C)nc2)n1.[Li+].[OH-]>>Cc1ccc(-c2nc(CC(=O)O)cs2)cn1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COCn1cc(Br)sc1=Nc1cccc(C(=O)OC)n1.O.[BH4-].[Li+]>>COCn1cc(Br)sc1=Nc1cccc(CO)n1",
        "output": "546"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.Cc1ccc(Oc2ccc(C)cc2CC#N)cc1.O.[K+].[OH-]>>Cc1ccc(Oc2ccc(C)cc2CC(=O)O)cc1",
        "output": "259"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCCCOc1ccc(OCc2ccccc2)cc1.C1CCOC1.[Pd]>>Oc1ccc(OCCCBr)cc1",
        "output": "23"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrBr.COC(=O)C(Oc1cccc(C(C)=O)c1)c1ccccc1>>COC(=O)C(Oc1cccc(C(=O)CBr)c1)c1ccccc1",
        "output": "173"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(C)=O.COC(=O)[C@@H]1C[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)CN1C(=O)OC(C)(C)C.O=S(=O)([O-])O.[K+].[Na+].[OH-]>>CC(C)(C)OC(=O)N1C[C@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN.Cc1ccc(Oc2ccc(Nc3ncnc4cccc(O[C@H](C)C(=O)O)c34)cc2C)cn1>>CNC(=O)[C@@H](C)Oc1cccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c12",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.Nc1ccc(C(=O)O)cc1[N+](=O)[O-].O=N[O-].[I-].[K+].[Na+]>>O=C(O)c1ccc(I)c([N+](=O)[O-])c1",
        "output": "200"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.COC(=O)c1ccc(Nc2nc(NCCCOCCCCOCCCN)nc(OCC(F)(F)F)n2)cc1.Cl.O.O=C([O-])[O-].[K+].[K+]>>NCCCOCCCCOCCCNc1nc(Nc2ccc(C(=O)O)cc2)nc(OCC(F)(F)F)n1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1nccc2c(-c3cc([N+](=O)[O-])ccc3F)cn(C)c12.CS(C)=O.O=C([O-])[O-].Oc1ccc(F)cc1F.[Cs+].[Cs+]>>COc1nccc2c(-c3cc([N+](=O)[O-])ccc3Oc3ccc(F)cc3F)cn(C)c12",
        "output": "564"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.Br.CCI.CN(C)C=O.Oc1ccc(-c2nc3n(c2-c2ccncc2)CCC3)cc1.[H-].[Na+]>>CCOc1ccc(-c2nc3n(c2-c2ccncc2)CCC3)cc1",
        "output": "198"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.F[P-](F)(F)(F)(F)F.O=C(O)CCO.O=S(=O)(c1ccccc1)n1cc(-c2cnn(C3CCNCC3)c2)c2ccc(F)cc21>>O=C(CCO)N1CCC(n2cc(-c3cn(S(=O)(=O)c4ccccc4)c4cc(F)ccc34)cn2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1cc(C#N)ccc1NS(=O)(=O)Nc1ccccc1.ClCCl>>N#Cc1ccc(NS(=O)(=O)Nc2ccccc2)c(O)c1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(C(C)(C)C)cc1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>CC(C)(C)c1ccc(CBr)cc1",
        "output": "29"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cl.Cl.N[C@H]1COc2ccccc2NC1=O.O=C(O)c1cc2cc(Cl)ccc2[nH]1.On1nnc2cccnc21>>O=C(N[C@H]1COc2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1",
        "output": "738"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.ClCCl.N#Cc1cccc(S(=O)(=O)Cl)c1.NCC1(c2ccc(OCCCN3CCCC3)cc2)CCOCC1>>N#Cc1cccc(S(=O)(=O)NCC2(c3ccc(OCCCN4CCCC4)cc3)CCOCC2)c1",
        "output": "43"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)N(NC(=O)c1ccccc1)C(=O)CCc1ccccc1Br.COCCOC.N#Cc1cccc(B(O)O)c1.O=C([O-])[O-].[Na+].[Na+]>>CC(C)N(NC(=O)c1ccccc1)C(=O)CCc1ccccc1-c1cccc(C#N)c1",
        "output": "837"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN.O=[N+]([O-])c1cnc(Cl)nc1Cl>>CNc1nc(Cl)ncc1[N+](=O)[O-]",
        "output": "110"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.CO.COC(=O)COc1ccc2c(c1)N(c1nc(-c3ccc(Cl)s3)nc3c1CCC3)CC2.NC1CC1>>O=C(COc1ccc2c(c1)N(c1nc(-c3ccc(Cl)s3)nc3c1CCC3)CC2)NC1CC1",
        "output": "392"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.COC[C@H](C)Oc1cc(Oc2ccc(C(=O)O)cc2F)cc(-c2ccc(-c3nccs3)[nH]2)c1.Cl.ClCCl.N.O.On1nnc2ccccc21>>COC[C@H](C)Oc1cc(Oc2ccc(C(N)=O)cc2F)cc(-c2ccc(-c3nccs3)[nH]2)c1",
        "output": "358"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.O=C1CCCCN1c1ccc([N+](=O)[O-])cn1.[Ni]>>Nc1ccc(N2CCCCC2=O)nc1",
        "output": "269"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1ccc(-c2ccc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)cc2)c(F)c1.O.O.[Li]O>>O=C(O)c1ccc(-c2ccc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)cc2)c(F)c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccn4c(C)nc(C)c4c3)sc2c1-c1ccc(Cl)cc1.Cc1cc2nc(-c3ccc4c(c3)nnn4C)sc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O>>Cc1cc2nc(-c3ccn4c(C)nc(C)c4c3)sc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)C(=O)Cl.CC(C)(C)OC(=O)N1CCC(CCC(=O)O)CC1.CCN(C(C)C)C(C)C.CNOC.Cl.ClCCl>>CON(C)C(=O)CCC1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "54"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(CO)[N+](=O)[O-].CCOCC.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.Cc1nn(-c2cc(OC(C)C(=O)O)c(Cl)cc2Cl)c(=O)n1C(F)F.O.O>>Cc1nn(-c2cc(OC(C)C(=O)OCC(C)[N+](=O)[O-])c(Cl)cc2Cl)c(=O)n1C(F)F",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1cccc(C=O)c1.NCCC1CCN(c2ccncc2)CC1.O=C(NCCC1CCN(c2ccncc2)CC1)c1cccc(-c2nc3c(Cl)cccc3s2)c1.O=C(O)C(F)(F)F.O=C(O)c1cccc(-c2nc3cccc(Cl)c3s2)c1.OB(O)c1cccc(-c2nc3c(Cl)cccc3s2)c1>>O=C(NCCC1CCN(c2ccncc2)CC1)c1cccc(-c2nc3cccc(Cl)c3s2)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)[O-].Cc1nc(C)c(-c2cn(CCC=O)c(=O)[nH]c2=O)s1.FC(F)(F)c1ccc([C@@]23CNC[C@@H]2C3)cc1>>Cc1nc(C)c(-c2cn(CCCN3C[C@@H]4C[C@]4(c4ccc(C(F)(F)F)cc4)C3)c(=O)[nH]c2=O)s1",
        "output": "484"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)OB(c2ccc(N)cc2)OC1(C)C.FC(F)(F)c1cc(N2CC3CCC(C2)O3)nc(Cl)n1>>Nc1ccc(-c2nc(N3CC4CCC(C3)O4)cc(C(F)(F)F)n2)cc1",
        "output": "974"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(N)c1cccc(O)c1.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COC(=O)c1sc(C(=O)O)cc1C.F[P-](F)(F)(F)(F)F.On1nnc2ccccc21>>COC(=O)c1sc(C(=O)NC(C)c2cccc(O)c2)cc1C",
        "output": "950"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)[C@@H]1C[C@@H](O)CN1c1nc(N)nc(-c2cc(Cl)ccc2Cl)n1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Nc1nc(-c2cc(Cl)ccc2Cl)nc(N2C[C@H](O)C[C@H]2CO)n1",
        "output": "430"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCBr.CN(C)C=O.Cc1ccc(-c2ccc(OCc3ccccc3)cc2)n1-c1ccc(O)cc1.O.O=C([O-])[O-].[K+].[K+]>>CCCCCCCCOc1ccc(-n2c(C)ccc2-c2ccc(OCc3ccccc3)cc2)cc1",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.N.N#CCCCn1c(CN2CCC[C@@H]3CCc4cccnc4[C@H]32)nc2ccccc21.[Ni]>>NCCCCn1c(CN2CCC[C@@H]3CCc4cccnc4[C@H]32)nc2ccccc21",
        "output": "246"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrBr.CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCCC3=O)C(=O)O1.ClC(Cl)Cl.ClCCl.O=C([O-])O.[Na+]>>CC(=O)NC[C@H]1CN(c2ccc3c(c2)CCCC(Br)C3=O)C(=O)O1",
        "output": "82"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.CC(C)O.COc1ccc(-c2nccn2-c2ccncc2)cc1.ClCCl.Cn1nnc(-c2ccncc2)c1-c1ccc(O)cc1>>Oc1ccc(-c2nccn2-c2ccncc2)cc1",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5ccccn5)CC4)ccc3OC)cc12.C[S+](C)[B-](Br)(Br)Br.ClCCCl>>CNC(=O)c1c(-c2ccc(F)cc2)oc2ccc(-c3cc(C(=O)NC4(c5ccccn5)CC4)ccc3O)cc12",
        "output": "786"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.OCc1cncn1-c1ccc(F)cc1.[Mn+4].[O-2].[O-2]>>O=Cc1cncn1-c1ccc(F)cc1",
        "output": "287"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)n1ncc2c(C(=O)O)cc(C3CC3)nc21.CN1CCOCC1.CS(C)=O.Cc1cc(C(F)(F)F)c(CN)c(=O)[nH]1.ClCCCl.On1nnc2cccnc21>>Cc1cc(C(F)(F)F)c(CNC(=O)c2cc(C3CC3)nc3c2cnn3C(C)C)c(=O)[nH]1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(COc2ccc3ncn(-c4cc(OCc5ccccc5C(F)(F)F)c(C(N)=O)s4)c3c2)CC1.CO.Cl>>NC(=O)c1sc(-n2cnc3ccc(OCC4CCNCC4)cc32)cc1OCc1ccccc1C(F)(F)F",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "B#B.C1CCOC1.O=C(O)c1ccccc1CCCCCCCBr>>OCc1ccccc1CCCCCCCBr",
        "output": "72"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)c1ccc2ncc(Cl)cc2c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1ccc2ncc(Cl)cc2c1",
        "output": "444"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.COC(=O)c1cc2cc(CNCc3cccc([N+](=O)[O-])c3)cnc2[nH]1>>COC(=O)c1cc2cc(CN(Cc3cccc([N+](=O)[O-])c3)C(=O)OC(C)(C)C)cnc2[nH]1",
        "output": "867"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1CN(C(=O)c1ccc(OC)c(OCCCOC)c1)C(C)C.CO.Cl.ClCCl.O.[Li]O>>COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2C(=O)O)C(C)C)ccc1OC",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.Nc1ccccc1Br.O=C(Cl)CCl>>O=C(CCl)Nc1ccccc1Br",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)/C(C)=C/c1cc(C2CCCCC2)n(-c2ccc(OCc3ccccc3)cc2)n1.ClB(Cl)Cl.ClCCl>>CCOC(=O)/C(C)=C/c1cc(C2CCCCC2)n(-c2ccc(O)cc2)n1",
        "output": "698"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCCCC(N)c1coc([Si](C)(C)C)c1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CCCCCCCCCCCCC(NS(C)(=O)=O)c1coc([Si](C)(C)C)c1",
        "output": "493"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CCOC(C)=O.CN1CC[C@@H](O)C1.CO.O=[N+]([O-])c1ccc(C(F)(F)F)c(F)c1.[H-].[Na+]>>CN1CC[C@@H](Oc2cc([N+](=O)[O-])ccc2C(F)(F)F)C1",
        "output": "485"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)OCC(Cn2cc(C(=O)NCc3ccc(Cl)cc3)c(=O)c3cc(CCl)sc32)O1.CN(C)C=O.CNC[C@@H](O)c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+]>>CN(Cc1cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(CC3COC(C)(C)O3)c2s1)C[C@@H](O)c1ccccc1",
        "output": "639"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.ClCCl.OCCc1ccc(Br)cc1>>CS(=O)(=O)OCCc1ccc(Br)cc1",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.CSc1ncc2c(n1)N(C)C(=O)N(c1ccc(F)c([N+](=O)[O-])c1)C2.[Pd]>>CSc1ncc2c(n1)N(C)C(=O)N(c1ccc(F)c(N)c1)C2",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNCC1.C1CCOC1.O=C(O)Cn1c(-c2ccc(Cl)c(Cl)c2)nc2cccnc21.O=C(n1ccnc1)n1ccnc1>>O=C(Cn1c(-c2ccc(Cl)c(Cl)c2)nc2cccnc21)N1CCCCC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1ccc2oc3ccccc3c2c1.CC(=O)O.II.O.O=S(=O)(O)O.[O-][I+](O)(O)(O)(O)O>>Brc1ccc2oc3ccc(I)cc3c2c1",
        "output": "372"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC1(CS[C@H]2C(O)CC(=O)[C@@H]2CC=CCCCC(=O)O)OCCO1.[BH4-].[Na+]>>CCCCCC1(CS[C@H]2C(O)CC(O)[C@@H]2CC=CCCCC(=O)O)OCCO1",
        "output": "91"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)c1cn([Si](C)(C)C(C)(C)C)c2ccc(B(O)O)cc12.CCN(CC)CC.Cc1cc(OCC(=O)OC(C)(C)C)cc(C)c1O.ClCCl.[Cu+2].c1ccncc1>>Cc1cc(OCC(=O)OC(C)(C)C)cc(C)c1Oc1ccc2c(c1)c(C(C)C)cn2[Si](C)(C)C(C)(C)C",
        "output": "920"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)N=C=NC(C)C.ClCCl.O=C(O)CCCCCN1C(=O)c2ccccc2C1=O.Oc1c(F)c(F)c(F)c(F)c1F>>O=C(CCCCCN1C(=O)c2ccccc2C1=O)Oc1c(F)c(F)c(F)c(F)c1F",
        "output": "108"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)c1sc(N2CC[C@H](N)C2)nc1C.CCc1[nH]c(C(=O)O)nc1Cl.CN1CCOCC1.Cl.On1nnc2ccccc21>>CCOC(=O)c1sc(N2CC[C@H](NC(=O)c3nc(Cl)c(CC)[nH]3)C2)nc1C",
        "output": "951"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Cl.CCCCCCCCCCCCCCCCOCC(O)CNC.CCN(CC)CC.ClC(Cl)Cl>>CCCCCCCCCCCCCCCCOCC(O)CN(C)C(C)=O",
        "output": "125"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCCCCOc1ccc2[nH]c(SC(C)(C(=O)O)c3ccccc3)cc2c1.Cl.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCCCCOc1ccc2[nH]c(SC(C)(CO)c3ccccc3)cc2c1",
        "output": "231"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C[Mg]Br.O=C1CCC(CO)CC1>>CC1(O)CCC(CO)CC1",
        "output": "514"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cl.NO.O=C([O-])[O-].O=C1CCC1c1ccccc1C(F)(F)F.[K+].[K+]>>ON=C1CCC1c1ccccc1C(F)(F)F",
        "output": "86"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1cc(-c2cccc(OCc3ccccc3)c2)c(C#N)n1N.[BH4-].[Na+]>>N#Cc1c(-c2cccc(OCc3ccccc3)c2)cc(CO)n1N",
        "output": "711"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.c1cncc(C2CCCN2)c1>>Cc1ccc(S(=O)(=O)N2CCCC2c2cccnc2)cc1",
        "output": "99"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O=[N+]([O-])c1ccc(OCCO)cc1CS(=O)(=O)c1ccccc1>>Cc1ccc(S(=O)(=O)OCCOc2ccc([N+](=O)[O-])c(CS(=O)(=O)c3ccccc3)c2)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.Cc1c(N)cccc1F.ClI.O=S([O-])[O-].[Na+].[Na+]>>Cc1c(N)ccc(I)c1F",
        "output": "466"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cl.NC[C@H]1CC[C@@H](CCOc2ccccc2)CC1.O=C(O)c1ccc2[nH]c(=O)sc2c1>>O=C(NC[C@@H]1CC[C@H](CCOc2ccccc2)CC1)c1ccc2[nH]c(=O)sc2c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "NCC1CCN(S(=O)(=O)CCc2ccc(F)cc2)CC1.O=C(O)c1ccc(O)cc1>>O=C(NCC1CCN(S(=O)(=O)CCc2ccc(F)cc2)CC1)c1ccc(O)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.ClCCl.Cn1cc(C(=O)O)c(C(F)F)n1.Nc1ccc(F)cc1-c1ccc(Cl)c(F)c1.O.O=C(Cl)C(=O)Cl>>Cn1cc(C(=O)Nc2ccc(F)cc2-c2ccc(Cl)c(F)c2)c(C(F)F)n1",
        "output": "851"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1cccc(-c2c(F)c(F)c(F)c(F)c2F)c1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1cccc(-c2c(F)c(F)c(F)c(F)c2F)c1",
        "output": "444"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(C)nc1.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>Cc1ccc(C)[n+]([O-])c1",
        "output": "262"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCC.Cc1ccc(Nc2cnc3c(n2)c(C(=O)NC(C)(C)CO)cn3COCC[Si](C)(C)C)nc1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(Nc2cnc3[nH]cc(C(=O)NC(C)(C)CO)c3n2)nc1",
        "output": "981"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCN1.CC#N.CCN(C(C)C)C(C)C.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Cc2ccnc(Cl)n2)cc1.O=C([O-])O.[Na+]>>Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2ccccc2Cc2ccnc(N3CCOCC3)n2)cc1",
        "output": "36"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCCCCCCO.CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-]>>CC(C)(C)OC(=O)NCCCCCC=O",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCO.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.O=C(O)CN1C(=O)C=CC1=O>>CCCCCOC(=O)CN1C(=O)C=CC1=O",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCOC(=O)C(C)(C)Oc1ccc(O)cc1C.Cc1c(CCCBr)sc2cc(Br)ccc12.O.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)C(C)(C)Oc1ccc(OCCCc2sc3cc(Br)ccc3c2C)cc1C",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(C)=O.Cc1cc(O)c([N+](=O)[O-])cc1S(C)(=O)=O>>Cc1cc(O)c(N)cc1S(C)(=O)=O",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].CCS(=O)(=O)c1ccc(O)nc1.[Na+]>>CCS(=O)(=O)c1cnc(O)c(Br)c1",
        "output": "292"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)C(C)(C)NC(=O)c1cc(Cl)c2ccccc2c1OCc1cnc(C(F)(F)F)nc1.O.O=C(O)C(F)(F)F>>CC(C)(NC(=O)c1cc(Cl)c2ccccc2c1OCc1cnc(C(F)(F)F)nc1)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.C[C@H](N)C1CCCCC1.Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)O>>Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)N[C@@H](C)C1CCCCC1",
        "output": "534"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(C)(C)C.NN.O=C1c2ccccc2C(=O)N1Cc1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1>>NCc1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1",
        "output": "418"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)O.CO.COC(=O)c1cccc(-c2ccc(CNC(=O)c3cccnc3Oc3ccc(F)cc3)cc2)c1.Cl.ClCCl.O.[Na+].[OH-]>>O=C(O)c1cccc(-c2ccc(CNC(=O)c3cccnc3Oc3ccc(F)cc3)cc2)c1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CCN(C(C)C)C(C)C.FC(F)(F)c1ccc(NC2CCNCC2)nn1.O=Cc1ccc(F)cc1>>Fc1ccc(CN2CCC(Nc3ccc(C(F)(F)F)nn3)CC2)cc1",
        "output": "567"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=C(NC(=O)c1cc(-c2ccc([N+](=O)[O-])cc2)no1)C(=O)OC.CCO.O.[Cl-].[Fe].[NH4+]>>C=C(NC(=O)c1cc(-c2ccc(N)cc2)no1)C(=O)OC",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCCCc1nc(C)c(Br)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.Cl[Pd]Cl.O=C([O-])[O-].OB(O)c1ccc(F)cc1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCCCc1nc(C)c(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "871"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.Cc1cc(O)cc(C)c1-c1cccc(C=O)c1.c1c[nH]cn1>>Cc1cc(O[Si](C)(C)C(C)(C)C)cc(C)c1-c1cccc(C=O)c1",
        "output": "746"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cl.ClCCl.O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1.O=C1CCC(n2ccccc2=O)CC1.[Na+]>>O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(n3ccccc3=O)CC2)C1",
        "output": "187"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COCCO.COc1cc(Nc2nc(C)cc(Cl)n2)ccc1-n1cnc(C)c1.[Na]>>COCCOc1cc(C)nc(Nc2ccc(-n3cnc(C)c3)c(OC)c2)n1",
        "output": "653"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#CCOc1ccc(Nc2nc(Cl)ncc2F)cc1.CC(C)O.Cc1ccc(N)cc1S(N)(=O)=O.Cl.O=C(O)C(F)(F)F>>C#CCOc1ccc(Nc2nc(Nc3ccc(C)c(S(N)(=O)=O)c3)ncc2F)cc1",
        "output": "808"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1ccc([N+](=O)[O-])cc1S(=O)(=O)NC(C)(C)C.[H][H].[Pd]>>COC(=O)c1ccc(N)cc1S(=O)(=O)NC(C)(C)C",
        "output": "772"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)C1=C(CBr)C(Br)S(=O)[C@@H]2C(NC(=O)c3ccccc3)C(=O)N12.O=C(O)C(F)(F)F>>O=C(O)C1=C(CBr)C(Br)S(=O)[C@@H]2C(NC(=O)c3ccccc3)C(=O)N12",
        "output": "158"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccccc3F)cs2)CC1.CCOC(C)=O.Cl>>Fc1ccccc1-c1csc(N2CCNCC2)n1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cc(Cl)nc(Cl)n1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cc(OC)nc(Cl)n1",
        "output": "653"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CN1CCN(c2ccc([N+](=O)[O-])cn2)CC1.[Pd]>>CN1CCN(c2ccc(N)cn2)CC1",
        "output": "269"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)O.O=C(Nc1cccc(C(F)(F)F)c1)c1ccc([N+](=O)[O-])cc1.[Zn]>>Nc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1",
        "output": "28"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.C[Si](C)(C)C#CC1(O)CC[NH2+]CC1.ClCCCl.ClCCl.O=C(O)Cc1ccc(-n2cnnn2)cc1.[Cl-]>>C[Si](C)(C)C#CC1(O)CCN(C(=O)Cc2ccc(-n3cnnn3)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(C)(C)CCC1CC(=O)C=C(C)C1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>COC(C)(C)CCC1CC(C)=CC(O)C1",
        "output": "288"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.CN(C)CC1CCc2cc(O)ccc2C1.COc1ccc(COc2ccc(CO)cc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(COc2ccc(COc3ccc4c(c3)CCC(CN(C)C)C4)cc2)cc1",
        "output": "347"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "N[C@@H]1CC[C@@H](c2ccccc2)CC1.O=C(Cl)c1ccc(Cl)cc1>>O=C(N[C@@H]1CC[C@@H](c2ccccc2)CC1)c1ccc(Cl)cc1",
        "output": "271"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC#N.CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)[C@@H](CCCN)C(=O)O.N[C@H](CCc1ccccc1)C(=O)OCc1ccccc1.O=C1CCC(=O)N1O>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)[C@@H](CCCN)C(=O)N[C@H](CCc1ccccc1)C(=O)OCc1ccccc1",
        "output": "132"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccccc1.CCO.CCOC(=O)C1(Cc2ccccc2)CCN(C(=O)OC(C)(C)C)CC1.O.O=S(=O)([O-])O.[Na+].[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC(Cc2ccccc2)(C(=O)O)CC1",
        "output": "281"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(CO)(CO)NCc1cc2c3ccccc3ccc2c2ccccc12.CC(O)C(=O)O>>CC(O)C(=O)OCC(C)(CO)NCc1cc2c3ccccc3ccc2c2ccccc12",
        "output": "47"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CN(C)C=O.FC(F)(F)c1ccc(CBr)cc1.O=C([O-])[O-].O=Cc1ccc(O)c(OCc2ccccc2)c1.[Cs+].[Cs+]>>O=Cc1ccc(OCc2ccc(C(F)(F)F)cc2)c(OCc2ccccc2)c1",
        "output": "127"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cc2nccc(Oc3cnc(CC(=O)O)c(OC)c3)c2cc1OC.Cc1nn(C(C)(C)C)c(N)c1C.F[P-](F)(F)(F)(F)F>>COc1cc2nccc(Oc3cnc(CC(=O)Nc4c(C)c(C)nn4C(C)(C)C)c(OC)c3)c2cc1OC",
        "output": "795"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cl.FC(F)(F)c1cccc([C@H]2CCNC[C@H]2c2ccccc2)c1.O=C(Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](c2cccc(C(F)(F)F)c2)[C@H](c2ccccc2)C1",
        "output": "201"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Brc1cccc2ccccc12.C=Cc1nc2c(=O)[nH]c(N)nc2n1[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O.CN(C)C=O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(=O)OC[C@H]1O[C@@H](n2c(C=Cc3cccc4ccccc34)nc3c(=O)[nH]c(N)nc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O",
        "output": "539"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)Nc1ccc2cc(C(=O)O)[nH]c2c1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N#Cc1cc(Cl)cc(Oc2c(Cl)ccc(CN)c2F)c1.O>>CC(C)(C)OC(=O)Nc1ccc2cc(C(=O)NCc3ccc(Cl)c(Oc4cc(Cl)cc(C#N)c4)c3F)[nH]c2c1",
        "output": "905"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.Cl.N#CCC1(n2cc(C(N)=O)c(N)n2)CCC2(CC1)OCCO2.O=C([O-])O.[Na+]>>N#CCC1(n2cc(C(N)=O)c(N)n2)CCC(=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCOC(COCc2ccccc2)C1.CO.[H][H].[Pd]>>CC(C)(C)OC(=O)N1CCOC(CO)C1",
        "output": "178"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)c1ccccc1Nc1cc(Cl)c(OCc2ccccc2)c(Cl)c1.[Pd]>>COC(=O)c1ccccc1Nc1cc(Cl)c(O)c(Cl)c1",
        "output": "698"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)C1CCN(c2nc(NCc3ccc4c(c3)OCO4)c3cc(C#N)ccc3n2)CC1.Cl.[Na+].[OH-]>>N#Cc1ccc2nc(N3CCC(C(=O)O)CC3)nc(NCc3ccc4c(c3)OCO4)c2c1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)CCSc2ccc(Br)cc21.CCCCC.CCOCC.O.O=C=O.[Li]C(C)(C)C>>CC1(C)CCSc2ccc(C(=O)O)cc21",
        "output": "654"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCCCCOc1ccc(C(=O)Cl)cc1.CCN(CC)CC.CCOCC.Cc1ccccc1.ClCCl.Oc1ccc(OCc2ccccc2)cc1>>CCCCCCCCCCOc1ccc(C(=O)Oc2ccc(OCc3ccccc3)cc2)cc1",
        "output": "482"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)CN1C(=O)C2CC(c3ccc([N+](=O)[O-])cc3)(C2)C1=O.CCO.[Pd]>>CC(C)CN1C(=O)C2CC(c3ccc(N)cc3)(C2)C1=O",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1ccc(Sc2cc(C3(C)COC(C4CC4)O3)cs2)cc1.Cl.NO>>CC(=NO)c1ccc(Sc2cc(C3(C)COC(C4CC4)O3)cs2)cc1",
        "output": "212"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CCCOc1ccc(C(=O)O)cc1.CCN(CC)CC.CN(C)C=O.ClCCl.O=S(Cl)Cl.O=c1ccc2ccc(O)cc2o1>>C=CCCOc1ccc(C(=O)Oc2ccc3ccc(=O)oc3c2)cc1",
        "output": "355"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)C(=O)NCc1ccc(Cl)c(-n2nc(-c3ccc(CBr)cc3)[nH]c2=O)c1.CCCC[N+](CCCC)(CCCC)CCCC.OCC(F)(F)F.[H-].[I-].[Na+]>>CC(C)(C)C(=O)NCc1ccc(Cl)c(-n2nc(-c3ccc(COCC(F)(F)F)cc3)[nH]c2=O)c1",
        "output": "464"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#CCCC(=O)O.C1CCNCC1.CCOC(C)=O.N#Cc1ccc(Br)cc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>N#Cc1ccc(C#CCCC(=O)O)cc1",
        "output": "659"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCCCCCCN(Cc1cccc(OC)c1OC)C(=O)COc1ccc(C[C@H](OCC)C(=O)OCC)cc1.Cl.[Li+].[OH-]>>CCCCCCCN(Cc1cccc(OC)c1OC)C(=O)COc1ccc(C[C@H](OCC)C(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCCCCCCCCCCCCCN1CCNCC1.CCN(CC)CC.O=C(Cl)c1ccc(CBr)cc1.[Ca+2].[Cl-].[Cl-].c1ccccc1>>CCCCCCCCCCCCCCCCCCN1CCN(C(=O)c2ccc(CBr)cc2)CC1",
        "output": "201"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cccc(CCCO)c1F.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>Cc1cccc(CCC=O)c1F",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(CC(=O)O)NC(=O)OCc1ccccc1.CCN(C(C)C)C(C)C.CN(C)C=O.CNCCN(C)C.O.O=C(n1ccnc1)n1ccnc1>>CN(C)CCN(C)C(=O)CC(C)(C)NC(=O)OCc1ccccc1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)/C=C/c1c(COC)nc2c(cnn2CC)c1-c1cncc(C)c1.Cl.O.[Cl-].[Na+].[Na+].[OH-]>>CCn1ncc2c(-c3cncc(C)c3)c(/C=C/C(=O)O)c(COC)nc21",
        "output": "122"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCO.CCOC(C)=O.Cc1nc(Cl)ncc1Br.Cl.O[C@H]1CCNC1>>Cc1nc(N2CC[C@H](O)C2)ncc1Br",
        "output": "36"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1cccc(C(=O)N2C[C@@H]3C[C@@H]3C[C@H]2CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)n1.[F-]>>Cc1cccc(C(=O)N2C[C@@H]3C[C@@H]3C[C@H]2CO)n1",
        "output": "781"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)c1cc([N+](=O)[O-])c(Cl)c([N+](=O)[O-])c1.CCO.CN.O>>CNc1c([N+](=O)[O-])cc(C(C)(C)C)cc1[N+](=O)[O-]",
        "output": "304"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COCC(=O)Cl.Cc1[nH]c2c(-c3cc(C(F)F)ccc3OCC3CC3)ncnc2c1C(=O)N[C@H]1CC[C@H](N)C[C@@H]1C.Cl>>COCC(=O)N[C@H]1CC[C@H](NC(=O)c2c(C)[nH]c3c(-c4cc(C(F)F)ccc4OCC4CC4)ncnc23)[C@@H](C)C1",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cc2ccc(C)c(NS(=O)(=O)c3cccs3)c2[nH]1.CO.O=C(O)CC(O)(CC(=O)O)C(=O)O.[K+].[OH-]>>Cc1ccc2cc(C(=O)O)[nH]c2c1NS(=O)(=O)c1cccs1",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1c(C)[nH]c(C=O)c1CCC(=O)O.CCOC(=O)c1c(CCC(=O)O)c[nH]c1C.O=C1Cc2ccc(-c3ccc(F)cc3)cc2N1>>CCOC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3cc(-c4ccc(F)cc4)ccc32)c1CCC(=O)O",
        "output": "440"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(Br)nc3C(=O)NC)n2)c(OC)c1)OC(C)C.[I-].[Na+].c1ccncc1>>CNC(=O)c1nc(Br)ccc1Nc1nc(Nc2ccc(CP(=O)(O)OC(C)C)cc2OC)ncc1C(F)(F)F",
        "output": "618"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCN1.CCOC(=O)C(Cc1ccccc1)CS(=O)(=O)Cl.Cl.ClCCl>>CCOC(=O)C(Cc1ccccc1)CS(=O)(=O)N1CCOCC1",
        "output": "584"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.N#CB([O-])[O-].N#Cc1ccc(-c2cnc(OC3CCNCC3)nc2)cc1.O=C1CCCC1.[Cl-].[Cl-].[Na+].[Na+].[Zn+2]>>N#Cc1ccc(-c2cnc(OC3CCN(C4CCCC4)CC3)nc2)cc1",
        "output": "187"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)CCC(Cc1c[nH]c2ccccc12)N(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.CO.O.[Li+].[OH-]>>CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCC(=O)O)Cc1c[nH]c2ccccc12",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cc(Cn2c(C)c(-c3ccc(C#N)cc3)c(C#N)c2C2CC2)cnc1Cl.O.[BH4-].[Ca+2].[Cl-].[Cl-].[Na+]>>Cc1c(-c2ccc(C#N)cc2)c(C#N)c(C2CC2)n1Cc1cnc(Cl)c(CO)c1",
        "output": "383"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.Nc1ccc(Br)cc1[N+](=O)[O-].[K+].[Pd+2]>>CC1(C)OB(c2ccc(N)c([N+](=O)[O-])c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "O=C(O)COc1ccccc1OCC(=O)O.O=S(=O)(O)Cl>>O=C(O)COc1ccc(S(=O)(=O)Cl)cc1OCC(=O)O",
        "output": "182"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.C[C@H]1C[C@@H](O)CN1.Cc1cc(Nc2ncnc(-c3ccc(F)c(C#N)c3)n2)ccc1N1CCN(C2COC2)CC1>>Cc1cc(Nc2ncnc(-c3ccc(N4C[C@H](O)C[C@@H]4C)c(C#N)c3)n2)ccc1N1CCN(C2COC2)CC1",
        "output": "26"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(N(CC(=O)O)S(=O)(=O)c2ccccc2C)cc1.OCCNCc1ccccn1>>Cc1ccc(N(CC(=O)N(CCO)Cc2ccccn2)S(=O)(=O)c2ccccc2C)cc1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1cc(-c2cncc(C(=O)O)c2)c(C)[nH]c1=O.NCCc1nc2ccccc2[nH]1>>CCc1cc(-c2cncc(C(=O)NCCc3nc4ccccc4[nH]3)c2)c(C)[nH]c1=O",
        "output": "674"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)n1cc(-c2nc(NCC(c3ccccc3)c3ccccc3)c3ccccc3n2)c2ccccc21.ClCCl.O=C(O)C(F)(F)F>>c1ccc(C(CNc2nc(-c3c[nH]c4ccccc34)nc3ccccc23)c2ccccc2)cc1",
        "output": "848"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-c2cc(-c3cnn(C)c3)cnc2N)cc1C.O.O.[Li]O>>Cc1cc(-c2cc(-c3cnn(C)c3)cnc2N)ccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.N#CCC(=O)O.N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1OC1CCNCC1>>N#CCC(=O)N1CCC(Oc2ccc(-c3ncnc(Nc4ccc(N5CCN(C6COC6)CC5)cc4)n3)cc2C#N)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cl.NO.O.O=Cc1cccc(OC(F)F)c1.[Na+].[OH-]>>ON=Cc1cccc(OC(F)F)c1",
        "output": "30"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CNC(=O)c1cccc(-c2ccc(C(O)Cc3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)cc2)c1.Cl.[C].[Pd]>>CNC(=O)c1cccc(-c2ccc(C(O)Cc3c[nH]cn3)cc2)c1",
        "output": "838"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1ccc2c(-c3ccccc3C(=O)O)cccc2c1.ClCCl>>O=C(O)c1ccccc1-c1cccc2cc(O)ccc12",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.O=C(O)c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)c(F)c12.OC1CNC1>>O=C(c1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)c(F)c12)N1CC(O)C1",
        "output": "733"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.COC(=O)c1ccc(Br)c(O)c1.COCCOCCO.COCCOCCOc1cc(C(=O)O)ccc1Br.Cl.Cl.NS(=O)(=O)c1ccccc1S(N)(=O)=O.O.O.[Li+].[OH-].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COCCOCCOc1cc(C(=O)NS(=O)(=O)c2ccccc2S(N)(=O)=O)ccc1Br",
        "output": "579"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.COc1cc(C(=O)O)ccc1N1CCCCC1=O.C[C@H](N)c1nc2cc(Cl)ccc2[nH]1.F[B-](F)(F)F>>COc1cc(C(=O)N[C@@H](C)c2nc3cc(Cl)ccc3[nH]2)ccc1N1CCCCC1=O",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COc1ccc(CN(C(=O)c2ccc(OC)c(-c3cccc(OC)c3)c2)c2cnc3cc(OCc4ccccc4)ccc3c2)cc1.COc1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(CN(C(=O)c2ccc(OC)c(-c3cccc(OC)c3)c2)c2cnc3cc(O)ccc3c2)cc1",
        "output": "23"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)c1c(O)c2ncc(Cc3ccccc3)cc2n(Cc2ccc(S(C)(=O)=O)cc2)c1=O.NCc1ccncc1>>CS(=O)(=O)c1ccc(Cn2c(=O)c(C(=O)NCc3ccncc3)c(O)c3ncc(Cc4ccccc4)cc32)cc1",
        "output": "498"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.Cc1cc(O)ccc1C(C)C.ClCCl.c1ccncc1>>CC(=O)Oc1ccc(C(C)C)c(C)c1",
        "output": "111"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(N)COC1.Cc1onc(-c2ccc(F)cn2)c1CNc1cc(C(=O)O)n(C)n1>>Cc1onc(-c2ccc(F)cn2)c1CNc1cc(C(=O)NC2(C)COC2)n(C)n1",
        "output": "816"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)Cc1cc2ccc(F)cc2c(Cc2ccc(S(=O)(=O)C(F)(F)F)cc2)c1C.O.O.[Li+].[OH-]>>Cc1c(CC(=O)O)cc2ccc(F)cc2c1Cc1ccc(S(=O)(=O)C(F)(F)F)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CC[NH2+]CCCC(=O)NCCF.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cn1c2c(c3cc(C(=O)O)ccc31)CC(C1CCOCC1)CC2.F[P-](F)(F)(F)(F)F.[Cl-]>>CCN(CCCC(=O)NCCF)C(=O)c1ccc2c(c1)c1c(n2C)CCC(C2CCOCC2)C1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)c1ccc(Cn2cncc(-c3ccc(O)c(F)c3)c2=O)cc1.COc1cc2nccc(Cl)c2cc1OC>>COc1cc2nccc(Oc3ccc(-c4cncn(Cc5ccc(C(C)(C)C)cc5)c4=O)cc3F)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1ccc(N2CCNCC2)c(F)c1.CN(C)C=O.N#Cc1ccc(Br)c(C(=O)O)c1.O=C(n1ccnc1)n1ccnc1.O=C=O>>CC(=O)c1ccc(N2CCN(C(=O)c3cc(C#N)ccc3Br)CC2)c(F)c1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCNc1cc(C#N)cc(S(N)(=O)=O)c1Oc1ccccc1.CCOC(C)=O.COCCOC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCCNc1cc(CN)cc(S(N)(=O)=O)c1Oc1ccccc1",
        "output": "175"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)CNC(=O)c1c(O)c(-c2ncc(C)s2)cc2nccnc12.[Na+].[OH-]>>Cc1cnc(-c2cc3nccnc3c(C(=O)NCC(=O)O)c2O)s1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.Cl.Cl.N#CCN1C[C@@H](N)[C@H](c2ccccc2)C1.NC(=O)CN1C[C@@H](c2ccccc2)[C@H](N)C1.O=C(Nc1c2c(nn1-c1ccccc1)CCC2)Oc1ccccc1>>NC(=O)CN1C[C@@H](c2ccccc2)[C@H](NC(=O)Nc2c3c(nn2-c2ccccc2)CCC3)C1",
        "output": "488"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOCC.CS(=O)(=O)Cl.OCC1CCC1>>CS(=O)(=O)OCC1CCC1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CI.OCC1CCC2(CC1)OCCO2.[H-].[Na+]>>COCC1CCC2(CC1)OCCO2",
        "output": "140"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)CO1.COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(Oc5ccc(O)cc5)ccc(F)c43)ccc21>>COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(Oc5ccc(OCC(C)(C)O)cc5)ccc(F)c43)ccc21",
        "output": "277"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)c1cc(C(C)C)c(S(=O)(=O)c2ccc(F)cc2)cc1S(=O)(=O)Cl.NCCc1ccncc1>>CC(C)c1cc(C(C)C)c(S(=O)(=O)c2ccc(F)cc2)cc1S(=O)(=O)NCCc1ccncc1",
        "output": "43"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCC1CC1.CCOC(=O)CNc1c(Cl)ccc2c1CCNC2.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CNc1c(Cl)ccc2c1CCN(CC1CC1)C2",
        "output": "722"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)c1nnn(-c2c(Cl)cccc2Cl)c1COc1ccc(-c2ccc(C(=O)O)cc2)c(Br)c1.O=S(Cl)Cl>>CC(C)c1nnn(-c2c(Cl)cccc2Cl)c1COc1ccc(-c2ccc(C(=O)Cl)cc2)c(Br)c1",
        "output": "3"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1cccc(-n2c(C)ccc2-c2cc(C(F)(F)F)ccc2OCc2ccc(Cl)cc2)c1.CCOC(C)=O.[Na+].[OH-]>>Cc1ccc(-c2cc(C(F)(F)F)ccc2OCc2ccc(Cl)cc2)n1-c1cccc(C(=O)O)c1",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCO.CNCCNC.COc1ccc(N(C)c2nc(Cl)nc3ccccc23)cc1.Cl>>CNCCN(C)c1nc(N(C)c2ccc(OC)cc2)c2ccccc2n1",
        "output": "36"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1.CCN(CC)CC.Nc1ccc(N2CCC3(CC2)OCCO3)cc1>>CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(N3CCC4(CC3)OCCO4)cc2)cc1",
        "output": "68"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)C(=O)CC(=O)C(C)(C)C.CCc1ccc(OC)c(Br)c1.CN1CCCC1=O.Cl[Cu].O=C([O-])[O-].Oc1ccccc1.[Cs+].[Cs+]>>CCc1ccc(OC)c(Oc2ccccc2)c1",
        "output": "238"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1ccc(CCN2C(=O)C3(CCNCC3)N(C)C2c2ccc(C3CC3)cc2)cc1.ClCCCl.ClCCl.O=C(O)C(F)(F)F.O=CC1CC1.[Na+]>>COc1ccc(CCN2C(=O)C3(CCN(CC4CC4)CC3)N(C)C2c2ccc(C3CC3)cc2)cc1",
        "output": "484"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(NCc2noc(-c3cc4cnccc4o3)n2)CC1.CC=O.ClCCl.[Na+]>>CCN(Cc1noc(-c2cc3cnccc3o2)n1)C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "484"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1cn(Cc2ccccc2)nc1[N+](=O)[O-])C(=O)O.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl.OCC(F)(F)F>>CC(C)(C)OC(=O)N[C@@H](Cc1cn(Cc2ccccc2)nc1[N+](=O)[O-])C(=O)OCC(F)(F)F",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.CCO[PH](=O)Cc1cccc(OC)c1.ClCCl>>CCO[PH](=O)Cc1cccc(O)c1",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1ccc2c(c1)c(-c1ccncc1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1.O.O=N[O-].O=S(=O)(O)O.[N-]=[N+]=[N-].[Na+].[Na+]>>[N-]=[N+]=Nc1ccc2c(c1)c(-c1ccncc1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "189"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(-c2ccnnc2)cc2c1c(C)cn2C(C)C.O.[Li+].[OH-]>>Cc1cn(C(C)C)c2cc(-c3ccnnc3)cc(C(=O)O)c12",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCCCO.CCN(CC)CC.CS(C)=O.ClCCl>>CC(C)(C)OC(=O)NCCC=O",
        "output": "142"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#CC(O)(c1ccc2nc(OC)c(Cc3ccc(C(F)(F)F)cc3)c(Cl)c2c1)C1CNC1.CC(=O)OC(C)=O.CCN(CC)CC.ClCCl>>C#CC(O)(c1ccc2nc(OC)c(Cc3ccc(C(F)(F)F)cc3)c(Cl)c2c1)C1CN(C(C)=O)C1",
        "output": "369"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccccc1F.ClC(Cl)Cl.O=C(Cl)Cc1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(C(=O)Cc2ccccc2)cc1F",
        "output": "31"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCc1ccc(C(=O)Cl)cc1.COC(=O)C(C(C)C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1>>CCCCCc1ccc(C(=O)Nc2ccc(-c3ccc4c(c3)CN(C(C(=O)OC)C(C)C)C4)cc2)cc1",
        "output": "11"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)CN1C(=O)C2(COc3cc4c(cc32)OCCO4)c2ccccc21.COC(=O)c1ccccc1CN1C(=O)C2(COc3cc4c(cc32)CCO4)c2ccccc21>>O=C(O)CN1C(=O)C2(COc3cc4c(cc32)OCCO4)c2ccccc21",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C.CCCCCC.CCO.CN(C(=O)CBr)c1cccc(-c2ccnc3c(C(=O)c4ccccc4)cnn23)c1.CNC>>CN(C)CC(=O)N(C)c1cccc(-c2ccnc3c(C(=O)c4ccccc4)cnn23)c1",
        "output": "443"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccccc1.ClCc1ccc(Cl)cc1.O.[K+].[OH-].c1ccc2[nH]ccc2c1>>Clc1ccc(Cn2ccc3ccccc32)cc1",
        "output": "556"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Brc1ccccc1.CC(C)(C)[O-].CCOCC.CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1cc(N2CCC(N)C2)c2cc(Oc3ccccc3)ccc2n1.Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1cc(N2CCC(Nc3ccccc3)C2)c2cc(Oc3ccccc3)ccc2n1",
        "output": "519"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C[Mg]Br.O=Cc1ccncc1Br>>CC(O)c1ccncc1Br",
        "output": "787"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1c1ccccc1SC.ClCCl.O=C(OO)c1cccc(Cl)c1>>CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1c1ccccc1S(C)=O",
        "output": "500"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1cn2c(cc(OC)c3ccccc32)n1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1cc2nc(CO)cn2c2ccccc12",
        "output": "286"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.Nc1ccc(S)cc1.O.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F.[Cl-].[Na+]>>O=C(Nc1ccc(S)cc1)C(F)(F)F",
        "output": "106"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCOc1ccc(-c2cc3cccc(OC)c3o2)cc1C(=O)OC.CO.[K+].[OH-]>>CCCOc1ccc(-c2cc3cccc(OC)c3o2)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CSc1ccc2c(c1)N(CCCCl)c1ccccc1S2.O=C([O-])O.O=C(c1ccc(F)cc1)C1CCNCC1.[Na+]>>CSc1ccc2c(c1)N(CCCN1CCC(C(=O)c3ccc(F)cc3)CC1)c1ccccc1S2",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1cccc(-c2cnc(C(=O)CCc3ccc(-c4ccc(CN5CCN(C)CC5)cc4)cc3)o2)n1.Cl.ClCCl.O.[Li+].[OH-]>>CN1CCN(Cc2ccc(-c3ccc(CCC(=O)c4ncc(-c5cccc(C(=O)O)n5)o4)cc3)cc2)CC1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)Oc1ccc(-c2nc(-c3ccc(O)c4ccoc34)no2)cc1Cl.CCOC(=O)CCCBr.CN(C)C=O.CO.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CCCOc1ccc(-c2noc(-c3ccc(OC(C)C)c(Cl)c3)n2)c2occc12",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)c1cn(-c2cc(C(C)(C)C)cc(C3(C)CC3)c2)cc1C.O=C1CCC(=O)N1Br.c1ccncc1>>COC(=O)c1cn(-c2cc(C(C)(C)C)cc(C3(C)CC3)c2)c(Br)c1C",
        "output": "779"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)N1CCc2cc(CC(C)N)cc(C#N)c21.CCO.FC(F)(F)COc1ccccc1OCCBr.O=C([O-])O.[Na+]>>CC(=O)N1CCc2cc(CC(C)NCCOc3ccccc3OCC(F)(F)F)cc(C#N)c21",
        "output": "147"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.Cc1ccc(S(=O)(=O)OCC(C)(C)C#N)cc1.Fc1ccc2ncc(-c3nccc(N[C@@H]4CCCNC4)n3)n2c1>>CC(C)(C#N)CN1CCC[C@@H](Nc2ccnc(-c3cnc4ccc(F)cn34)n2)C1",
        "output": "429"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrBr.Cc1ccc(C(=O)O)c(C)c1.Cl.O.[Na+].[OH-]>>Cc1cc(C)c(C(=O)O)cc1Br",
        "output": "98"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CI.CN(C)C=O.NC(=O)Nc1cn(-c2ccc(-c3cc(F)ccc3O)c(F)c2)nc1C(N)=O.O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(F)cc1-c1ccc(-n2cc(NC(N)=O)c(C(N)=O)n2)cc1F",
        "output": "62"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc(/C=C/c2ccc3c(c2)c2cc(Cl)cnc2n3S(=O)(=O)c2ccccc2)cc1.[F-]>>COc1ccc(/C=C/c2ccc3[nH]c4ncc(Cl)cc4c3c2)cc1",
        "output": "831"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1CCC(O)CN1.CCN(CC)CC.ClCCl.O=C(Cl)OCc1ccccc1>>CC1CCC(O)CN1C(=O)OCc1ccccc1",
        "output": "427"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(C)=O.ClCCl.OCC1CCNC1>>CC(C)(C)OC(=O)N1CCC(CO)C1",
        "output": "694"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.Cc1ccccc1.FC1CCCNC1.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)cc1F.[Na+].[Na+]>>O=[N+]([O-])c1ccc(Cl)cc1N1CCCC(F)C1",
        "output": "26"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CI.CN(C)C=O.ClCCl.O=C(O)c1cccc(Br)n1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cccc(Br)n1",
        "output": "415"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)CC1CNCCN1S(=O)(=O)c1ccc2ccccc2c1.O=C(Cl)C1CCN(c2ccncc2)CC1>>COC(=O)CC1CN(C(=O)C2CCN(c3ccncc3)CC2)CCN1S(=O)(=O)c1ccc2ccccc2c1",
        "output": "125"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(C)=O.CSc1nc(-c2cnc(N)nc2)c2c(n1)N([C@@]1(C)CCN(C(=O)OC(C)(C)C)C1)CC2.ClCCl.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nc(-c2cnc(N)nc2)c2c(n1)N([C@@]1(C)CCN(C(=O)OC(C)(C)C)C1)CC2",
        "output": "595"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1ccccn1.CCN(C(C)C)C(C)C.CS(C)=O.C[C@H]1CNCCN1C(=O)OC(C)(C)C>>C[C@H]1CN(c2ccccn2)CCN1C(=O)OC(C)(C)C",
        "output": "647"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C(=O)OC(C)(C)C)C1CCNCC1.CN(C)C=O.Clc1cncc(Cl)n1>>CN(C(=O)OC(C)(C)C)C1CCN(c2cncc(Cl)n2)CC1",
        "output": "505"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=c1n(-c2ccc(OCC(F)(F)C(F)F)cc2)cnn1-c1ccc([N+](=O)[O-])cc1.[C].[Pd]>>Nc1ccc(-n2ncn(-c3ccc(OCC(F)(F)C(F)F)cc3)c2=O)cc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.NCc1cccc(CCc2ccccc2)c1.Nc1ncccc1C(=O)O>>Nc1ncccc1C(=O)NCc1cccc(CCc2ccccc2)c1",
        "output": "790"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=[N+]([O-])CC(O)C1CC(F)(F)C1.[Pd]>>NCC(O)C1CC(F)(F)C1",
        "output": "226"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCN1CCNCC1.Cc1ccc2c(NCc3ccc(NC(=O)c4ccc(F)cc4)cc3)nc(Cl)nc2c1>>CCN1CCN(c2nc(NCc3ccc(NC(=O)c4ccc(F)cc4)cc3)c3ccc(C)cc3n2)CC1",
        "output": "36"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.Brc1cccc2cc[nH]c12.CN(C)C=O.[H-].[Na+]>>Brc1cccc2ccn(Cc3ccccc3)c12",
        "output": "528"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)CCC(=O)c1ccc(-c2ccc(Br)cc2)cc1.Cl>>O=C(O)CCC(=O)c1ccc(-c2ccc(Br)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O=C(N[C@@H]1CC[C@@H](O)CC1)OCc1ccccc1.O=C([O-])O.[Na+].c1c[nH]cn1>>CC(C)(C)[Si](C)(C)O[C@@H]1CC[C@@H](NC(=O)OCc2ccccc2)CC1",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)CN.Cc1ccc(S(=O)(=O)OC[C@@H]2COc3ccc(S(C)(=O)=O)cc3O2)cc1>>CC(C)CNC[C@@H]1COc2ccc(S(C)(=O)=O)cc2O1",
        "output": "853"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)CN.CCOC(=O)Cc1ccc(OC)c(Oc2ccc(C(=O)O)cc2CSC(C)(C)C)c1>>CCOC(=O)Cc1ccc(OC)c(Oc2ccc(C(=O)NCC(C)(C)C)cc2CSC(C)(C)C)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.Nc1cccc(Br)n1.O.O=C1CCC(=O)N1Cl.[Cl-].[Na+]>>Nc1ccc(Cl)c(Br)n1",
        "output": "743"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1cc(-c2cccc3[nH]ccc23)cc2nn(C3CCCCO3)cc12.[H][H].[Pd]>>Nc1cc(-c2cccc3[nH]ccc23)cc2nn(C3CCCCO3)cc12",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1onc(-c2ccccn2)c1COc1ccc(C(=O)O)nc1.F[B-](F)(F)F.NC1CCOCC1>>Cc1onc(-c2ccccn2)c1COc1ccc(C(=O)NC2CCOCC2)nc1",
        "output": "137"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "B.C1CCOC1.CSC.Cl.N#Cc1ccc(Oc2ccc(CCNCc3ccccc3)cc2)nc1.[Na+].[OH-]>>NCc1ccc(Oc2ccc(CCNCc3ccccc3)cc2)nc1",
        "output": "560"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCNCC(O)COc1ccc(C#N)cc1.ClCCCSc1ccccc1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CCN(CCCSc1ccccc1)CC(O)COc1ccc(C#N)cc1",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(O)c1ccn2c(Br)cnc2n1.CC1(C)OB(c2ccc(F)c(-c3ccccc3C#N)c2)OC1(C)C>>CC(C)(O)c1ccn2c(-c3ccc(F)c(-c4ccccc4C#N)c3)cnc2n1",
        "output": "937"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)[C@@H]1COCC[C@H]1NC(=O)OC(C)(C)C.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC(C)(C)OC(=O)N[C@@H]1CCOC[C@H]1CO",
        "output": "225"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCI.Cn1c(=O)c(-c2ccc(Cl)cc2Cl)cc2c3cc(-c4cc[nH]n4)ccc3n(C(F)F)c21>>CCn1ccc(-c2ccc3c(c2)c2cc(-c4ccc(Cl)cc4Cl)c(=O)n(C)c2n3C(F)F)n1",
        "output": "346"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.Cn1ccc2ccc(S(=O)(=O)Cl)cc21.O=C1CCC(=O)N1Br>>Cn1cc(Br)c2ccc(S(=O)(=O)Cl)cc21",
        "output": "796"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccccc1-n1nc(C(C)(C)C)cc1N.O=C(O)Cc1ccc(-n2cnc3cccnc32)cc1>>Cc1ccccc1-n1nc(C(C)(C)C)cc1NC(=O)Cc1ccc(-n2cnc3cccnc32)cc1",
        "output": "795"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCO.CCCOc1ncc(C(=O)O)cc1Br.Cl.ClCCl.O.O=C(O)c1cnc(Cl)c(Br)c1.O=C([O-])[O-].[Cs+].[Cs+]>>CCCOc1ncc(CO)cc1Br",
        "output": "293"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(CC4CN(Cc5ccccc5)CCO4)c4ccc(OC(F)F)cc34)nc12.CCOC(C)=O.CO.[H][H].[Pd]>>CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(CC4CNCCO4)c4ccc(OC(F)F)cc34)nc12",
        "output": "84"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CNC.FC(F)(F)/C(=C(\\c1ccccc1)c1ccc(OCCBr)cc1)c1ccccc1>>CN(C)CCOc1ccc(/C(=C(\\c2ccccc2)C(F)(F)F)c2ccccc2)cc1",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)N(CC(=O)O)S(=O)(=O)c1ccc(F)cc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.NCc1cc(-c2ccc(C(F)(F)F)nc2)ccn1.O=S(=O)([O-])O.[K+]>>CC(C)N(CC(=O)NCc1cc(-c2ccc(C(F)(F)F)nc2)ccn1)S(=O)(=O)c1ccc(F)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2CCC(OCCOC)CC2)c2ncnn12.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(C2CCC(OCCOC)CC2)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=[N+]([O-])c1ccc(Cc2cccnc2)cc1.[H][H].[Pd]>>Nc1ccc(Cc2cccnc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.c1nc(N2CCCNC3(CC3)C2)c2cc[nH]c2n1>>Cc1ccc(S(=O)(=O)N2CCCN(c3ncnc4[nH]ccc34)CC23CC3)cc1",
        "output": "99"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)c1cnc(C(F)(F)C(F)(F)F)nc1C(F)F.Cl.[Na+].[OH-]>>O=C(O)c1cnc(C(F)(F)C(F)(F)F)nc1C(F)F",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.Cc1n[nH]c2cccc(OS(=O)(=O)C(F)(F)F)c12>>Cc1nn(C(=O)OC(C)(C)C)c2cccc(OS(=O)(=O)C(F)(F)F)c12",
        "output": "841"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN.CO.N#Cc1c(-c2ccnc(F)c2)sc(-c2nnc[nH]2)c1-c1ccc(Cl)cc1Cl>>CNc1cc(-c2sc(-c3nnc[nH]3)c(-c3ccc(Cl)cc3Cl)c2C#N)ccn1",
        "output": "810"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(N)(C#N)COc1ccc2c(c1Br)B(O)OC2.CCN(C(C)C)C(C)C.Cl.O=C(Cl)c1ccc(OC(F)(F)F)cc1.O=S(Cl)Cl>>CC(C#N)(COc1ccc2c(c1Br)B(O)OC2)NC(=O)c1ccc(OC(F)(F)F)cc1",
        "output": "271"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CN(C)C=O.Cc1nc2ccccc2[nH]1.Cn1c(CN2CCC(C3COC3)CC2)nc2c(N3CCOCC3)nc(Cl)nc21.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(C4COC4)CC3)n(C)c2n1",
        "output": "916"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1cc(C2CCCCC2)c(-c2ccc3nc(-c4sc(C)nc4C)ccc3c2)n1CC(=O)N1CCOCC1.[Na+].[OH-]>>Cc1nc(C)c(-c2ccc3cc(-c4c(C5CCCCC5)cc(C(=O)O)n4CC(=O)N4CCOCC4)ccc3n2)s1",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.C[C@H](CCOc1ccc(S(C)(=O)=O)cc1)C1CCN(c2noc(C3CCCN3C(=O)OC(C)(C)C)n2)CC1.Cl>>C[C@H](CCOc1ccc(S(C)(=O)=O)cc1)C1CCN(c2noc(C3CCCN3)n2)CC1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.Cc1cc(Br)c(N)c(C(=O)O)c1.Cc1cc(Br)c2nc[nH]c(=O)c2c1.N=CN.O=P(Cl)(Cl)Cl>>Cc1cc(Br)c2ncnc(Cl)c2c1",
        "output": "14"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(Cn2cc(C(C)=O)c(C(F)F)n2)cc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.ClC(Cl)Cl.[Br-].[Br-].[Br-]>>COc1ccc(Cn2cc(C(=O)CBr)c(C(F)F)n2)cc1",
        "output": "360"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc(Cl)ccc1C(N)c1ccccc1.Cc1ncccc1-c1ccc2cc(CC(=O)O)ccc2n1>>Cc1cc(Cl)ccc1C(NC(=O)Cc1ccc2nc(-c3cccnc3C)ccc2c1)c1ccccc1",
        "output": "769"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.Oc1cccc(N2CCNCC2)c1>>CC(C)(C)OC(=O)N1CCN(c2cccc(O)c2)CC1",
        "output": "694"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CCN(CC)CC.NC1CCN(CCc2c[nH]c3ccccc23)CC1.O=C(O)c1ccc2ncccc2c1>>O=C(NC1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc2ncccc2c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.O=Cc1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)c(F)c1.OC1CNC1>>OC1CN(Cc2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)c(F)c2)C1",
        "output": "567"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN.C[Si](C)(C)CCOCn1ccc2nc(NC(=O)N[C@H]3CC[C@H](C(=O)O)C3)cnc21.Cl.ClCCl>>CNC(=O)[C@H]1CC[C@H](NC(=O)Nc2cnc3c(ccn3COCC[Si](C)(C)C)n2)C1",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)C=O.COC(=O)c1cnc(N2CCNCC2)cn1.Cc1ccc2c(c1)c(C(=O)O)c(-c1ccccc1)n2C.Cl.O.On1nnc2ccccc21>>COC(=O)c1cnc(N2CCN(C(=O)c3c(-c4ccccc4)n(C)c4ccc(C)cc34)CC2)cn1",
        "output": "256"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCO/N=C(/c1ccc(Br)cc1)C1CCN(C2(C)CCNCC2)CC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1cccc2ncccc12>>CCO/N=C(/c1ccc(Br)cc1)C1CCN(C2(C)CCN(C(=O)c3cccc4ncccc34)CC2)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O=C(O)CSCCCCCCCCCCC(=O)N1CCOCC1.O=S(=O)(O)c1ccc2ccccc2c1.c1ccccc1>>CCOC(=O)CSCCCCCCCCCCC(=O)N1CCOCC1",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN.CCOC(=O)c1cn(C2CC3CCC2C3)c2nc(Nc3ccc(N4CCN(C)CC4)cc3)ncc2c1=O.CO>>CCNC(=O)c1cn(C2CC3CCC2C3)c2nc(Nc3ccc(N4CCN(C)CC4)cc3)ncc2c1=O",
        "output": "498"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(Br)ccc1O.N#Cc1ccc(B(O)O)cc1>>Cc1cc(-c2ccc(C#N)cc2)ccc1O",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Cl.CN(C)C=O.NCc1cc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)ccc1Cl.O.c1ccncc1>>CC(=O)NCc1cc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)ccc1Cl",
        "output": "206"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCI.CN(C)C=O.O=C(c1ccc(F)cc1)c1cc(Br)cc2cc[nH]c12.[H-].[H][H].[Na+]>>CCn1ccc2cc(Br)cc(C(=O)c3ccc(F)cc3)c21",
        "output": "302"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)O)(CC1)CC2.N#Cc1ccc(N)cc1>>N#Cc1ccc(NC(=O)C23CCC(NCC(=O)N4C[C@@H](F)C[C@H]4C#N)(CC2)CC3)cc1",
        "output": "365"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(CC)CC.Nc1cc(-c2nc(-c3ccco3)no2)ccc1Cl.S=C(Cl)Cl>>S=C=Nc1cc(-c2nc(-c3ccco3)no2)ccc1Cl",
        "output": "114"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)(c2cc(F)cc(Cl)c2)C1.CI.[H-].[Na+]>>COC1(c2cc(F)cc(Cl)c2)CCN(C(=O)OC(C)(C)C)C1",
        "output": "140"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.CC(C)C(=O)N1N=C(c2cccc(F)c2)SC1(CCCN)c1ccccc1.O=C([O-])[O-].[Na+].[Na+].[Na+]>>CC(C)NCCCC1(c2ccccc2)SC(c2cccc(F)c2)=NN1C(=O)C(C)C",
        "output": "236"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CO[C@@H]1CC[C@@H](N2CCC(N)CC2)CC1.Cc1cc(F)c([N+](=O)[O-])c(F)c1.Cl.Cl>>CO[C@@H]1CC[C@@H](N2CCC(Nc3cc(C)cc(F)c3[N+](=O)[O-])CC2)CC1",
        "output": "572"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)CCCCCCCCCCCSc1[nH]cnc2ncnc1-2.O.[K+].[OH-]>>O=C(O)CCCCCCCCCCCSc1[nH]cnc2ncnc1-2",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.Nc1cc(N2CCNCC2)c(Cl)cc1[N+](=O)[O-]>>CC(C)(C)OC(=O)N1CCN(c2cc(N)c([N+](=O)[O-])cc2Cl)CC1",
        "output": "694"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)NC1CC2CC1C1C=CCC21.CC(C)(C)OC(=O)NC1CC2CC1C1CC=CC21.CO.[Pd]>>CC(C)(C)OC(=O)NC1CC2CC1C1CCCC21",
        "output": "143"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCN(CC1CC1)c1cc(C(=O)OC)ncn1.CCO.O.[Li+].[OH-]>>CCCN(CC1CC1)c1cc(C(=O)O)ncn1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.O=C(O)[C@H]1CC[C@@H](O)CC1.O=C([O-])[O-].O=S(=O)(O)O.[Na+].[Na+]>>CCOC(=O)[C@H]1CC[C@@H](O)CC1",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=C(O)c1cc([N+](=O)[O-])[nH]n1.[H][H].[Pd]>>Nc1cc(C(=O)O)n[nH]1",
        "output": "684"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.Cc1cn([C@@H]2O[C@H](COCc3ccc(Cl)cc3Cl)[C@@H](OCc3ccc(Cl)cc3Cl)[C@@]2(C)O)c2nc(N)nc(Cl)c12.[H-].[Na+]>>CO[C@]1(C)[C@H](OCc2ccc(Cl)cc2Cl)[C@@H](COCc2ccc(Cl)cc2Cl)O[C@H]1n1cc(C)c2c(Cl)nc(N)nc21",
        "output": "140"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)n1nc(CCCO)c2c(Nc3c(-c4ncccn4)oc4cnccc34)ccc(Cl)c21.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)n1nc(CCCOS(C)(=O)=O)c2c(Nc3c(-c4ncccn4)oc4cnccc34)ccc(Cl)c21",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.Clc1nccnc1OC1CCCN(c2ccc3ccccc3n2)C1.O.O=C([O-])[O-].OCC1CCNCC1.[K+].[K+]>>OCC1CCN(c2nccnc2OC2CCCN(c3ccc4ccccc4n3)C2)CC1",
        "output": "505"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]cnc12.[Na+].[OH-]>>O=C(Nc1cc(C(=O)O)c2nc[nH]c2c1)c1ccccc1C(F)(F)F",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)c1cccc(N2CCN(C(=O)OC(C)(C)C)CC2)c1.Cl.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCN(c2cccc(C(=O)O)c2)CC1",
        "output": "5"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCl.N#Cc1cccc(F)c1.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>N#Cc1cc(F)ccc1[N+](=O)[O-]",
        "output": "103"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1cn(CCNC(=O)OC(C)(C)C)c(Cl)c1-c1cccc(C#N)c1.Cl.N.O>>COC(=O)c1cn(CCN)c(Cl)c1-c1cccc(C#N)c1",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCI.OC1CCCCCCCCCCC1.[H-].[Na+]>>CCCOC1CCCCCCCCCCC1",
        "output": "307"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)Nc1ccc(C(F)(F)F)cc1N.CC1(C)OB(c2ccc(N=C=O)cc2)OC1(C)C.CCN(CC)CC.CN(C)c1ccncc1>>CC(=O)Nc1ccc(C(F)(F)F)cc1NC(=O)Nc1ccc(B2OC(C)(C)C(C)(C)O2)cc1",
        "output": "473"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(=O)Cl.CCCOc1ccc2c(c1-c1ncnc3c(C(=O)N[C@@H]4CCNC4)c[nH]c13)OCO2>>CCCOc1ccc2c(c1-c1ncnc3c(C(=O)N[C@@H]4CCN(C(=O)CC)C4)c[nH]c13)OCO2",
        "output": "125"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(=O)[O-].CCOC(C)=O.COC(OC)OC.CS(=O)(=O)N1CC[NH2+]CC1.ClCCCl.O=Cc1cc2c(N3CCOCC3)nc(Cl)nc2s1.[Cl-].[Na+].[Na+]>>CS(=O)(=O)N1CCN(Cc2cc3c(N4CCOCC4)nc(Cl)nc3s2)CC1",
        "output": "792"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)c1[nH]n(-c2c(Cl)cc(Cl)cc2Cl)c2nc(Cc3ccc(N)cc3)nc(=O)c1-2.CCN(CC)CC.CN(C)C=O.O=C(Cl)CCl>>CC(C)c1[nH]n(-c2c(Cl)cc(Cl)cc2Cl)c2nc(Cc3ccc(NC(=O)CCl)cc3)nc(=O)c1-2",
        "output": "9"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CN1CCOCC1.ClCCl.Nc1cccc2c(=O)occc12.O=C(Cl)CC12CC3CC(CC(C3)C1)C2>>O=C(CC12CC3CC(CC(C3)C1)C2)Nc1cccc2c(=O)occc12",
        "output": "9"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)C(C)c1c(C)n(S(=O)(=O)c2ccc(Cl)c(Cl)c2)c2ncccc12.[Na+].[OH-]>>Cc1c(C(C)C(=O)O)c2cccnc2n1S(=O)(=O)c1ccc(Cl)c(Cl)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCCc1ccccc1.CN(C)C=O.O=Cc1cccc(O)c1>>O=Cc1cccc(OCCc2ccccc2)c1",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(C2(O)COC2)c1.ClCCl.O.O=C([O-])O.O=P(O)(O)O.[Na+].[Na+].[OH-]>>Nc1cccc(C2(O)COC2)c1",
        "output": "782"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Clc1ccccc1Oc1cccc(N2CCNCC2)n1.O=C(NCC(F)(F)F)C1(CCCCBr)c2ccccc2-c2ccccc21>>O=C(NCC(F)(F)F)C1(CCCCN2CCN(c3cccc(Oc4ccccc4Cl)n3)CC2)c2ccccc2-c2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1ccc(C(=O)O)cc1Br.CI.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(C(C)=O)c(Br)c1",
        "output": "415"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cnn(CC2CC2)c1C(F)(F)F.CO.O.[Li+].[OH-]>>O=C(O)c1cnn(CC2CC2)c1C(F)(F)F",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.COc1ccc(Oc2c(Cl)cc([N+](=O)[O-])cc2Cl)cc1C(C)C.ClCCl>>CC(C)c1cc(Oc2c(Cl)cc([N+](=O)[O-])cc2Cl)ccc1O",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.CCOC(=O)C1(Sc2ccnc3ccc(OC)cc23)CCC1.ClCCl.O.O=C([O-])O.[Na+]>>CCOC(=O)C1(Sc2ccnc3ccc(O)cc23)CCC1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "FC(F)(F)c1ccc2c(c1)CNCC2.O=C(O)CN1CCC(c2ccc(F)cc2)(c2ccc(F)cc2)C1=O.O=C(O)CN1CCCC(c2ccc(F)cc2)(c2ccc(F)cc2)C1=O.c1ccc(C2(c3ccccc3)CCNC2)cc1>>O=C(CN1CCC(c2ccc(F)cc2)(c2ccc(F)cc2)C1=O)N1CCc2ccc(C(F)(F)F)cc2C1",
        "output": "633"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.O.O=C(O)C(F)(F)F.O=C([O-])O.[Na+].c1ccc(CCCNC2CCC3(CC2)OCCO3)cc1>>O=C1CCC(NCCCc2ccccc2)CC1",
        "output": "251"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)c1cc(-c2ccc(C)cn2)cc(N2CCOCC2=O)c1.[Li+].[OH-]>>Cc1ccc(-c2cc(C(=O)O)cc(N3CCOCC3=O)c2)nc1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CSc1nc(Cl)c2cc[nH]c2n1.C[Si](C)(C)CCOCCl.[H-].[Na+]>>CSc1nc(Cl)c2ccn(COCC[Si](C)(C)C)c2n1",
        "output": "712"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCC(CO)Cc1ccc(Cl)c(Cl)c1Cl.O=S(Cl)Cl>>CCCCC(CCl)Cc1ccc(Cl)c(Cl)c1Cl",
        "output": "96"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CCOCC.CN1CCOCC1.COC(=O)c1ccc(N)cc1.O=C(O)CCc1ccc2c(c1)OCO2>>COC(=O)c1ccc(NC(=O)CCc2ccc3c(c2)OCO3)cc1",
        "output": "710"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(C)=O.Cc1cc(Cl)nc(N2CC[C@@H](F)C2)c1[N+](=O)[O-].O=C([O-])O.[Na+].c1cnc2c(c1)CNCC2>>Cc1cc(N2CCc3ncccc3C2)nc(N2CC[C@@H](F)C2)c1[N+](=O)[O-]",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)C[AlH]CC(C)C.COC(=O)c1ccc(NC(=O)c2nnn(Cc3ccc(Cl)c(Cl)c3)c2C)c(OC)c1.Cl.O.[Cl-].[NH4+]>>COc1cc(CO)ccc1NC(=O)c1nnn(Cc2ccc(Cl)c(Cl)c2)c1C",
        "output": "444"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N(C)C.Cl.Nc1cn2nc(I)ccc2n1.O.O=C(Cl)C1CC1>>O=C(Nc1cn2nc(I)ccc2n1)C1CC1",
        "output": "399"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(-c2nc3cc(-c4ccccc4)ccc3o2)cc1N.O=C(O)c1ccc2c(c1)C(=O)OC2=O>>COc1ccc(-c2nc3cc(-c4ccccc4)ccc3o2)cc1N1C(=O)c2ccc(C(=O)O)cc2C1=O",
        "output": "475"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCBr.CN(C)C=O.O=C([O-])[O-].Oc1cccc(Br)c1.[I-].[K+].[K+].[K+]>>CC(C)(C)OC(=O)NCCOc1cccc(Br)c1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.C[O-].Clc1nnc(Cc2ccncc2)c2ccccc12.Oc1cccc(O)c1.[Na+]>>Oc1cccc(Oc2nnc(Cc3ccncc3)c3ccccc23)c1",
        "output": "603"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CO.O=C(OCc1ccccc1)N1CCC2(CC1)Oc1ncccc1-n1cccc12.[Pd]>>c1cnc2c(c1)-n1cccc1C1(CCNCC1)O2",
        "output": "428"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)c1cnc(NC(=O)Cc2ccc(N)cc2)s1.CN(C)C=O.CN(C)c1ccncc1.COCC(=O)O>>COCC(=O)Nc1ccc(CC(=O)Nc2ncc(C(C)C)s2)cc1",
        "output": "365"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.CNCc1cc2ccccc2n1C.ClCCCl.Nc1ccc(/C=C/C(=O)O)cn1.O.On1nnc2ccccc21>>CN(Cc1cc2ccccc2n1C)C(=O)/C=C/c1ccc(N)nc1",
        "output": "811"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CO.Cl.O=C(Cc1cccc[n+]1[O-])c1ccccc1.[BH3-]C#N.[NH4+].[Na+]>>NC(Cc1cccc[n+]1[O-])c1ccccc1",
        "output": "552"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)Cc1nnnn1CCC1OC(c2cccc(OC)c2OC)c2cc(Cl)ccc2-n2c(C=C(C)C)ccc21.Cl.O=C([O-])[O-].[K+].[K+]>>COc1cccc(C2OC(CCn3nnnc3CC(=O)O)c3ccc(C=C(C)C)n3-c3ccc(Cl)cc32)c1OC",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COCC(C)(C)C(=O)O.F[P-](F)(F)(F)(F)F.NC(=O)C1CCNCC1.O>>COCC(C)(C)C(=O)N1CCC(C(N)=O)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COc1cc(OC)cc(-c2cc(=O)c3ccc(OCC4CO4)cc3o2)c1.c1ccc(N2CCNCC2)cc1>>COc1cc(OC)cc(-c2cc(=O)c3ccc(OCC(O)CN4CCN(c5ccccc5)CC4)cc3o2)c1",
        "output": "76"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CS(=O)(=O)c1ccc(Oc2ccc([N+](=O)[O-])c(OC3CCOCC3)c2)cn1.[C].[Pd]>>CS(=O)(=O)c1ccc(Oc2ccc(N)c(OC3CCOCC3)c2)cn1",
        "output": "335"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(CCOc1ccc(CCO)cc1)c1nc2ccccc2o1.CS(C)=O.ClCCl>>CN(CCOc1ccc(CC=O)cc1)c1nc2ccccc2o1",
        "output": "142"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.COc1ccc(C(=O)Cl)cc1.ClCCl.NCCCNc1nsc2ncccc12>>COc1ccc(C(=O)NCCCNc2nsc3ncccc23)cc1",
        "output": "271"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1=CCCCC1.CCO.Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NCC(C)(N)COCc1ccccc1.[Pd]>>Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NCC(C)(N)CO",
        "output": "178"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.CNCCN(C)C(=O)OC(C)(C)C.O=C([O-])[O-].O=S1(=O)N(CCBr)c2ccccc2N1c1ccccc1F.[Na+].[Na+]>>CN(CCN(C)C(=O)OC(C)(C)C)CCN1c2ccccc2N(c2ccccc2F)S1(=O)=O",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc2c(Oc3ccc4[nH]c(C)c(C)c4c3)ncnc2cc1O.OCCOc1ccncc1>>COc1cc2c(Oc3ccc4[nH]c(C)c(C)c4c3)ncnc2cc1OCCOc1ccncc1",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)Oc1ccc([N+](=O)[O-])cc1.c1ccc(C2CCNCC2)cc1>>O=C(NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O)N1CCC(c2ccccc2)CC1",
        "output": "770"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccccc1.CN(C)C=O.C[C@H]1CNC[C@@H](C)N1>>C[C@H]1CN(Cc2ccccc2)C[C@@H](C)N1",
        "output": "248"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)c1cnn(-c2ccccc2)c1C.CCOCC.CO.Cl.[H-]>>Cc1c(CO)cnn1-c1ccccc1",
        "output": "471"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cc1ccccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(C(=O)O)cc1.F[P-](F)(F)(F)(F)F.NC[C@@H](O)CO>>Cc1ccccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(C(=O)NC[C@@H](O)CO)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNCC1.CC(C)=O.O=C(Cc1ccccc1Cl)c1ccc(OCCCl)cc1>>O=C(Cc1ccccc1Cl)c1ccc(OCCN2CCCCC2)cc1",
        "output": "138"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.COC(=O)c1cc2cc(N)ccc2n1Cc1ccc(Cl)c(Cl)c1>>COC(=O)c1cc2cc(NC(C)=O)ccc2n1Cc1ccc(Cl)c(Cl)c1",
        "output": "6"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(=O)c1ccc(NC(C)=O)cc1.O=[N+]([O-])O>>CCC(=O)c1ccc(NC(C)=O)c([N+](=O)[O-])c1",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(SCc4ccc(C)nc4)cc2)CCN3CC(C)C)cc1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=S([O-])([O-])=S.[Na+].[Na+]>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(S(=O)Cc4ccc(C)nc4)cc2)CCN3CC(C)C)cc1",
        "output": "500"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.C[C@H](N)C1CCOCC1.Fc1cccc(Br)n1.O>>C[C@H](Nc1cccc(Br)n1)C1CCOCC1",
        "output": "810"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CC1C(=O)N(CC(=O)O)CC(c2ccccc2Cl)c2cc(Cl)ccc21.CCN(CC)CC.CCOC(=O)C1CCNCC1.CCOC(C)=O.CCOP(=O)(C#N)OCC.CN(C)C=O>>CCOC(=O)C1CCN(C(=O)CN2CC(c3ccccc3Cl)c3cc(Cl)ccc3C(CC(C)C)C2=O)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc2c(N)cc(=O)[nH]c2c1OCC1CC1.CS(C)=O.Clc1cncc(Cl)c1Cl.[H-].[Na+]>>COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)[nH]c2c1OCC1CC1",
        "output": "115"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1ccc(-c2nc(CS(=O)(=O)c3ccccc3)c(C)o2)cc1.Cl>>Cc1oc(-c2ccc(C(=O)O)cc2)nc1CS(=O)(=O)c1ccccc1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.O.O=C1CCc2c1cccc2-c1ccccc1.[BH4-].[Na+]>>OC1CCc2c(-c3ccccc3)cccc21",
        "output": "24"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CO.Cc1c(Cl)cccc1-c1cc(Cl)nc(N)n1.Cc1nc(CCN)n[nH]1.Cl>>Cc1nc(CCNc2cc(-c3cccc(Cl)c3C)nc(N)n2)n[nH]1",
        "output": "166"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)c1c(O)cc(C)cc1O.CCO.Cl.NO.O.O.O.O.O.[Na+]>>CC(=NO)c1c(O)cc(C)cc1O",
        "output": "212"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)N1CCC(NC(=O)c2nc3c(C(=O)O)cccc3n2CC(=O)Nc2ccc(Cl)cn2)CC1.CN(C)c1ccncc1.ClCCl.OCC1CC1>>CC(C)N1CCC(NC(=O)c2nc3c(C(=O)OCC4CC4)cccc3n2CC(=O)Nc2ccc(Cl)cn2)CC1",
        "output": "521"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cc(-c2[nH]c3ccccc3c2C)cc(C)c1O.O=S(=O)(O)O.O=[N+]([O-])[O-].[Na+]>>Cc1cc(-c2[nH]c3ccc([N+](=O)[O-])cc3c2C)cc(C)c1O",
        "output": "103"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc2ccncc2cc1-c1ccc(N(C)C2CC(C)(C)N(C)C(C)(C)C2)nn1.Sc1ccccc1>>CN(c1ccc(-c2cc3cnccc3cc2O)nn1)C1CC(C)(C)N(C)C(C)(C)C1",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)c1ccc2nc(-c3ccc(-c4ccc(OC)cc4)cc3)n(C[C@@H]3CCN(C(=O)C4CC4)C3)c2c1.O=S(=O)([O-])O.[Li+].[Na+].[OH-]>>COc1ccc(-c2ccc(-c3nc4ccc(C(=O)O)cc4n3C[C@@H]3CCN(C(=O)C4CC4)C3)cc2)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC=CCBr.CCC[C@@H]1CC[C@@H]([C@@H]2CC[C@@H]([C@@H]3CC[C@@H](O)CC3)CC2)CC1.CN(C)C=O.[H-].[Na+]>>CC=CCO[C@@H]1CC[C@@H]([C@@H]2CC[C@@H]([C@@H]3CC[C@@H](CCC)CC3)CC2)CC1",
        "output": "120"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)CCCOc1ccccc1N(C)C(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(C)cc2)cc1.Cc1ccccc1.ClCCl.[H-]>>Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N(C)c3ccccc3OCCCC=O)cc2)cc1",
        "output": "260"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)COc1cccc(C=O)c1.COCCc1nc2c(N)nc3ccccc3c2n1CCCCN>>CCOC(=O)COc1cccc(CNCCCCn2c(CCOC)nc3c(N)nc4ccccc4c32)c1",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(C)=O.Clc1ccc(Cl)nc1.O=C([O-])[O-].O=Cc1cccc(O)c1.[Cs+].[Cs+]>>O=Cc1cccc(Oc2ccc(Cl)cn2)c1",
        "output": "516"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1ccc(CCC(=O)O)cc1.CC(C)(C)c1ccc(CCC(=O)O)cc1.CN(C)C=O.C[Si](C)(C)c1cc(Br)cc([Si](C)(C)C)c1.ClCCl.O=S(Cl)Cl>>CC(C)(C)c1ccc(CCC(=O)Cl)cc1",
        "output": "53"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)/C=C/CCCCC(=O)O.CCCCCC.COc1cc(CO)ccc1O.O>>COc1cc(COC(=O)CCCC/C=C/C(C)C)ccc1O",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)N.CS(=O)(=O)Cl.Cl.ClC(Cl)Cl>>CC(C)(C)NS(C)(=O)=O",
        "output": "493"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCCBr.COC(=O)c1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(OCCBr)cc1",
        "output": "385"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)n1ncnc1-c1cc2n(n1)-c1cc(C3CNC3)ccc1OCC2.CO.ClCCl.NC(=O)CBr>>CC(C)n1ncnc1-c1cc2n(n1)-c1cc(C3CN(CC(N)=O)C3)ccc1OCC2",
        "output": "443"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCOCCCl.CN(C)C=O.O.O=C([O-])[O-].OCc1ccccc1O.[I-].[K+].[K+].[Na+]>>CCCOCCOc1ccccc1CO",
        "output": "74"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCCC(CO)C1.CCI.CN(C)C=O.[H-].[Na+]>>CCOCC1CCCN(C(=O)OC(C)(C)C)C1",
        "output": "307"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Nc1cc(Cl)cc(C(=O)O)c1.O=S(Cl)Cl>>COC(=O)c1cc(N)cc(Cl)c1",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COCCOCCOCCS(=O)c1ccc(N)cc1OC.COc1c(NC(=O)Nc2ccc(Oc3ccnc(Cl)c3)c3ccccc23)cc(C(C)(C)C)cc1NS(C)(=O)=O.COc1ccc(OC)c(P(C2CCCCC2)C2CCCCC2)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.ClCCl.O=C([O-])[O-].[K+].[K+]>>COCCOCCOCCS(=O)c1ccc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(NS(C)(=O)=O)c4OC)c4ccccc34)ccn2)cc1OC",
        "output": "434"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNCC1.CCc1nc2ccccc2c(=O)n1-c1ccc(OCCCCl)cc1.CN(C)C=O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CCc1nc2ccccc2c(=O)n1-c1ccc(OCCCN2CCCCC2)cc1",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Clc1cncc(Cl)n1.c1ccc2c(c1)OCC(CN1CCNCC1)O2>>Clc1cncc(N2CCN(CC3COc4ccccc4O3)CC2)n1",
        "output": "505"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CS(C)=O.F[P-](F)(F)(F)(F)F.NCc1ccccc1.O.O=C(O)c1ccn(CCCCn2cc(C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)c(=O)c1>>O=C(NCc1ccccc1)c1ccn(CCCCn2cc(C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)c(=O)c1",
        "output": "753"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1ccc(C#C[Se]c2cc(OCc3ccc(C)cc3)c3c(c2)C(C)(C)CCC3(C)C)cc1.[Na+].[OH-]>>Cc1ccc(COc2cc([Se]C#Cc3ccc(C(=O)O)cc3)cc3c2C(C)(C)CCC3(C)C)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCOc1cc(C(F)(F)F)ccc1C1=NC(c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)N1C(=O)N1CCNCC1.CO.FC(F)(F)C1CO1>>CCOc1cc(C(F)(F)F)ccc1C1=NC(c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)N1C(=O)N1CCN(CC(O)C(F)(F)F)CC1",
        "output": "76"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CNCc1sc(NC(C)=O)nc1/C=C\\c1ccc([N+](=O)[O-])cc1.CS(=O)(=O)c1ccc(C(=O)O)cc1.Cl.ClCCl.On1nnc2ccccc21>>CC(=O)Nc1nc(/C=C\\c2ccc([N+](=O)[O-])cc2)c(CN(C)C(=O)c2ccc(S(C)(=O)=O)cc2)s1",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=C(O)c1cccnc1O.O=S(=O)(O)O.c1ccccc1>>COC(=O)c1cccnc1O",
        "output": "521"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOc1ccc2ccccc2c1C(=O)O.c1ccc(-c2ccnc(N3CC4CNCC4C3)n2)cc1>>CCOc1ccc2ccccc2c1C(=O)N1CC2CN(c3nccc(-c4ccccc4)n3)CC2C1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=[N+]([O-])c1ccc(CCCn2cncn2)cc1.[Ca+2].[Cl-].[Cl-]>>Nc1ccc(CCCn2cncn2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.O=C(O)c1ccc2cncc(-c3ccc(Cl)cc3)c2n1.O=C(n1ccnc1)n1ccnc1.[NH4+].[OH-]>>NC(=O)c1ccc2cncc(-c3ccc(Cl)cc3)c2n1",
        "output": "136"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNCC1.CS(C)=O.N#Cc1cc(Br)ccc1F.O=C([O-])[O-].[Cs+].[Cs+]>>N#Cc1cc(Br)ccc1N1CCCCC1",
        "output": "26"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.COc1cc(N)c(Cl)cc1C(=O)O.Cl.ClCCCl.Nc1nccs1.O.On1nnc2ccccc21>>COc1cc(N)c(Cl)cc1C(=O)Nc1nccs1",
        "output": "918"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCO.c1ccc(CN2CCC(NCc3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)CC2)cc1>>CC(C)(C)OC(=O)N(Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)C1CCN(Cc2ccccc2)CC1",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=[N+]=[N-].O=C(O)c1ccc2cc[nH]c2c1>>COC(=O)c1ccc2cc[nH]c2c1",
        "output": "60"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CN(C)C=O.COc1ccc(CCl)cc1.Cc1c(Br)c[nH]c(=O)c1[N+](=O)[O-].[H-].[Na+]>>COc1ccc(Cn2cc(Br)c(C)c([N+](=O)[O-])c2=O)cc1",
        "output": "556"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOc1cc(C(=O)O)ccc1[N+](=O)[O-].[Pd]>>CCOc1cc(C(=O)O)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1coc2ccc(C=O)cc12.O=C1CSC(=O)N1>>Cc1coc2ccc(C=C3SC(=O)NC3=O)cc12",
        "output": "761"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cc1cc(C#C[Si](C)(C)C)ccc1OC(F)F.O=C([O-])[O-].[K+].[K+]>>C#Cc1ccc(OC(F)F)c(C)c1",
        "output": "337"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1NCCn2c(-c3ccco3)nnc21.O=C(O)c1cc2ncc(Br)cn2n1>>CC1c2nnc(-c3ccco3)n2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "663"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1c(Cl)nc2cc(F)ccc2c1Cl.Cc1ccccc1.N#Cc1cccc(B(O)O)c1.O.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Cc1c(-c2cccc(C#N)c2)nc2cc(F)ccc2c1Cl",
        "output": "865"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1nc(N)c(C#N)c(-c2ccc(N)cc2)c1C#N.CS(=O)(=O)Cl.Cl.Cl.O>>COc1nc(N)c(C#N)c(-c2ccc(NS(C)(=O)=O)cc2)c1C#N",
        "output": "194"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CN(C)C=O.O.O=C(O)c1ccc2c(C3CC3)nn(-c3ncc(-c4ccccc4)cn3)c2c1.On1nnc2cccnc21>>O=C(c1ccc2c(C3CC3)nn(-c3ncc(-c4ccccc4)cn3)c2c1)N1CCOCC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)C1CCN(C2=NOC3(C2)CN(Cc2cc(C4CC4)c(-c4ccc(F)cc4)cc2OC)C3)CC1.Cl.[Na+].[OH-]>>COc1cc(-c2ccc(F)cc2)c(C2CC2)cc1CN1CC2(CC(N3CCC(C(=O)O)CC3)=NO2)C1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClC(Cl)Cl.O=S(Cl)Cl.O=[N+]([O-])c1ccc(OCCc2ccc(CO)cn2)cc1>>O=[N+]([O-])c1ccc(OCCc2ccc(CCl)cn2)cc1",
        "output": "477"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CCc1cc(Oc2ccccc2)ccc1O.CCOC(C)=O.[Pd]>>CCCc1cc(Oc2ccccc2)ccc1O",
        "output": "116"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(-c2ccc(Br)cc2)cc1.O[C@@H]1CCNC1>>O=C(c1ccc(-c2ccc(Br)cc2)cc1)N1CC[C@@H](O)C1",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccccc1.O=C(O)Cc1ccc(Br)cc1.O=S(Cl)Cl>>O=C(Cl)Cc1ccc(Br)cc1",
        "output": "53"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOP(=O)(OCC)On1nnc2ccccc2c1=O.COC(=O)N[C@@H](CNC(N)=O)C(=O)O.COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(-c2ccccn2)cc1)C[C@H](O)[C@@H](N)Cc1ccccc1)C(C)(C)C>>COC(=O)N[C@@H](CNC(N)=O)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)Cc1cn(Cc2ccc(OCc3nc(-c4ccccc4)oc3C)nc2)nc1-c1ccccc1.Cl.[Na+].[OH-]>>Cc1oc(-c2ccccc2)nc1COc1ccc(Cn2cc(CC(=O)O)c(-c3ccccc3)n2)cn1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C(C)(C)Oc1ccc(Oc2ccc(F)c(C#N)c2)cc1C.N#Cc1ccccc1Oc1ccccc1>>CCOC(=O)C(C)(C)Oc1ccc(Oc2ccc(F)c(CN)c2)cc1C",
        "output": "175"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CNc1nc(C)c(-c2ccnc(Nc3cccc(CN)c3)n2)s1.CS(=O)(=O)Cl>>CNc1nc(C)c(-c2ccnc(Nc3cccc(CNS(C)(=O)=O)c3)n2)s1",
        "output": "742"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.Cl.Cn1cc(Br)cc(Nc2ccc(C3CN(C(=O)OC(C)(C)C)C3)cn2)c1=O>>Cn1cc(Br)cc(Nc2ccc(C3CNC3)cn2)c1=O",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCNC(=O)c1ccc(S(=O)(=O)c2ccc(CN)cc2)cc1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2nccn2c1>>CCNC(=O)c1ccc(S(=O)(=O)c2ccc(CNC(=O)c3ccc4nccn4c3)cc2)cc1",
        "output": "790"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(-c2ccc(Cl)cc2)nc(-c2ccnc(-c3ccc(S(=O)(=O)NC(C)(C)C)s3)c2)n1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(-c2ccc(Cl)cc2)nc(-c2ccnc(-c3ccc(S(N)(=O)=O)s3)c2)n1",
        "output": "680"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.O=C(O)C1CCc2ccccc2C1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCC1CCc2ccccc2C1",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#Cc1ccc(N)nc1N.C1CCOC1.CCN(CC)CC.Cc1ccnc(OCc2ccc(CC(Cl)=NO)cc2)c1.O>>Cc1ccnc(OCc2ccc(Cc3cc(-c4ccc(N)nc4N)on3)cc2)c1",
        "output": "976"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cl[Sn](Cl)(Cl)Cl.NCC(=O)OCc1ccccc1.O=C(CNS(=O)(=O)c1cccc([N+](=O)[O-])c1)OCc1ccccc1.O=[N+]([O-])c1cccc(S(=O)(=O)Cl)c1>>Nc1cccc(S(=O)(=O)NCC(=O)OCc2ccccc2)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCCC1=O.CN1CCCc2c(-c3ccnc(Cl)n3)c(-c3ccc(F)cc3)nn21.NC1CC1.O>>CN1CCCc2c(-c3ccnc(NC4CC4)n3)c(-c3ccc(F)cc3)nn21",
        "output": "544"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(-c5c(C)cc(OCCS(C)=O)cc5C)ccc(F)c43)ccc21.Cl.[Na+].[OH-]>>Cc1cc(OCCS(C)=O)cc(C)c1-c1ccc(F)c2c1CC[C@H]2Oc1ccc2c(c1)OC[C@H]2CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1cccc(N)c1.COc1ccc2c(Cl)nc(Nc3cc[nH]n3)cc2c1>>CCc1cccc(Nc2nc(Nc3cc[nH]n3)cc3cc(OC)ccc23)c1",
        "output": "434"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.COc1ccc(CCC(=O)Cl)cc1OC.NCc1ccc([N+](=O)[O-])cc1.O>>COc1ccc(CCC(=O)NCc2ccc([N+](=O)[O-])cc2)cc1OC",
        "output": "206"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NC1CCN(C(=O)Cc2nc(-c3ccncc3)n[nH]2)C1.ClCCl.O=C(O)C(F)(F)F>>NC1CCN(C(=O)Cc2nc(-c3ccncc3)n[nH]2)C1",
        "output": "538"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.NN.O.O=[N+]([O-])c1cccc(CN2CCCCC2)c1.[Ni]>>Nc1cccc(CN2CCCCC2)c1",
        "output": "71"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CC[C@@H](CO)N1C(=O)[C@@H](CC(=O)OC(C)(C)C)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC[C@@H](C=O)N1C(=O)[C@@H](CC(=O)OC(C)(C)C)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#CCN1CCc2ccc(N)cc2CC1.CNC(=O)c1ccccc1Nc1nc(Cl)ncc1Cl>>C#CCN1CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc2CC1",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCBr.CN(C)C=O.O=[N+]([O-])c1c(Br)n[nH]c1Br.[H-].[Na+]>>CCCn1nc(Br)c([N+](=O)[O-])c1Br",
        "output": "577"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.OCCCO.[H-].[Na+]>>CC(C)(C)[Si](C)(C)OCCCO",
        "output": "193"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCCCC.C[C@@H](O)c1cccnc1.O=C(Cl)C12CC3CC(CC(C3)C1)C2.[Li]CCCC>>C[C@@H](OC(=O)C12CC3CC(CC(C3)C1)C2)c1cccnc1",
        "output": "126"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)Cl.Nc1ccc2c(c1)CCC2=O.c1ccncc1>>CCOC(=O)Nc1ccc2c(c1)CCC2=O",
        "output": "102"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(=O)c1cn[nH]c1-n1nc(C(Nc2ccc(C(=N)N)cc2)c2cc(OC)cc(OCCCO)c2F)[nH]c1=O.CN(C)C=O.CN(C)c1ccncc1.O=C(O)C(F)(F)F>>COc1cc(OCCCO)c(F)c(C(Nc2ccc(C(=N)N)cc2)c2nn(-c3[nH]ncc3C(=O)O)c(=O)[nH]2)c1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cc1cc(Cn2ccnc2C(Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)cc(Cl)n1.[Pd]>>Cc1cc(Cn2ccnc2C(Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)ccn1",
        "output": "40"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C(=O)O.ClCCCl.ClCCl.NNc1ccc(F)cn1.O.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CC(C)C(=O)NNc1ccc(F)cn1",
        "output": "459"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC(c2cc(-c3ccc(Cl)cc3)nn2-c2ncccn2)OCC1CCc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>Clc1ccc(-c2cc(C3CNC(CCc4ccccc4)CO3)n(-c3ncccn3)n2)cc1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)N=C(c2ccc(Br)cc2)N(C[C@@H]2CCNC2)C1=O.CCN(CC)CC.ClCCl.O=C(Cl)C1CC1.O=C([O-])O.[Na+]>>CC1(C)N=C(c2ccc(Br)cc2)N(C[C@@H]2CCN(C(=O)C3CC3)C2)C1=O",
        "output": "125"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.O=C(Cl)c1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-].c1ccccc1>>O=C(c1ccccc1)c1ccccc1",
        "output": "61"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.O=C([O-])O.O=S([O-])O.OCc1ccc(F)c2ccccc12.[Na+].[Na+]>>O=Cc1ccc(F)c2ccccc12",
        "output": "179"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C(=O)O)n1ccc(-c2cc(Cl)ccc2C#N)cc1=O.Nc1ccc(-c2ncc[nH]2)cc1>>CC(C(=O)Nc1ccc(-c2ncc[nH]2)cc1)n1ccc(-c2cc(Cl)ccc2C#N)cc1=O",
        "output": "365"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Cn1c(CO[Si](C)(C)C(C)(C)C)cc2cc(Br)ccc21.O=C=O.[Li]CCCC>>Cn1c(CO[Si](C)(C)C(C)(C)C)cc2cc(C(=O)O)ccc21",
        "output": "654"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C(N)=O)N1CCNCC1.CCn1c(CN2CCC3(CCNC3=O)CC2)nc2c(N3CCOCC3)nc(Cl)nc21.Cn1c(C=O)nc2c(N3CCOCC3)nc(Cl)nc21>>Cn1c(CN2CCN(C(C)(C)C(N)=O)CC2)nc2c(N3CCOCC3)nc(Cl)nc21",
        "output": "944"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.O.O=[N+]([O-])c1cc(S(=O)(=O)Cl)ccc1Cl.c1ccc2c(c1)CCCCN2>>O=[N+]([O-])c1cc(S(=O)(=O)N2CCCCc3ccccc32)ccc1Cl",
        "output": "791"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=COC1CC(C)(C)NC(C)(C)C1.CC(=O)OC(C)=O.c1ccncc1>>C=COC1CC(C)(C)N(C(C)=O)C(C)(C)C1",
        "output": "369"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNCC1.CC(CO)Cc1ccc(C(C)(C)C)cc1.CO.[Pd]>>CC(Cc1ccc(C(C)(C)C)cc1)CN1CCCCC1",
        "output": "371"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.CC1(C)CCCC(C)(C)N1[O].O=c1n(Cl)c(=O)n(Cl)c(=O)n1Cl.OCc1cc2ccoc2cn1>>O=Cc1cc2ccoc2cn1",
        "output": "263"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2)C1(C#N)c1ccc(Cl)cc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(CN1CCNCC1)N1CCOCC1>>CC(C)(C)CC1NC(C(=O)N2CCN(CC(=O)N3CCOCC3)CC2)C(c2cccc(Cl)c2)C1(C#N)c1ccc(Cl)cc1",
        "output": "685"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "B.B.C1CCOC1.CO.ClC(Cl)Cl.O.O=C(O)Cc1ccc(OCc2ccccc2)cc1[N+](=O)[O-]>>O=[N+]([O-])c1cc(OCc2ccccc2)ccc1CCO",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1c(S(N)(=O)=O)cc(-c2cc(C(=O)OC(C)(C)C)cc(C(C)(C)C)c2)n1CC1CCCCC1.ClCCl.O=C(O)C(F)(F)F>>Cc1c(S(N)(=O)=O)cc(-c2cc(C(=O)O)cc(C(C)(C)C)c2)n1CC1CCCCC1",
        "output": "752"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)Cn1c(C(=O)Nc2nc(-c3cc(OC)c(Cl)cc3OC)c(CCC3CCCCC3)s2)cc2cc(C)ccc21.Cl>>COc1cc(-c2nc(NC(=O)c3cc4cc(C)ccc4n3CC(=O)O)sc2CCC2CCCCC2)c(OC)cc1Cl",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.CN(C)C=O.Cc1cc(C(=O)O)cnc1CC(C)C.F[P-](F)(F)(F)(F)F.N.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>Cc1cc(C(N)=O)cnc1CC(C)C",
        "output": "704"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCC(=O)Nc1cccc(C2CCN(CCCN)CC2)c1.O=C(O)C1(c2ccc(Cl)cc2)CC1>>CCCC(=O)Nc1cccc(C2CCN(CCCNC(=O)C3(c4ccc(Cl)cc4)CC3)CC2)c1",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.CC(C)(CO)COc1cccc([N+](=O)[O-])c1C#N>>CC(=O)OCC(C)(C)COc1cccc([N+](=O)[O-])c1C#N",
        "output": "126"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCOC(=O)CC1CCCCN1.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCOC(=O)CC1CCCCN1C(=O)C(F)(F)F",
        "output": "397"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CC2CN(c3cc(Cl)ccc3C=O)CC2C1.Cl.ClCCCl.O=C(OC(C(F)(F)F)C(F)(F)F)N1CCNCC1.[Na+]>>CC(C)(C)OC(=O)N1CC2CN(c3cc(Cl)ccc3CN3CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC3)CC2C1",
        "output": "567"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.NCc1ccc(-c2nc(C(=O)O)c3ccccc3n2)cc1>>CC(=O)NCc1ccc(-c2nc(C(=O)O)c3ccccc3n2)cc1",
        "output": "515"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cl.O=C1CCC2(CC1)OCCO2.[BH4-].[Cl-].[Na+].[Na+]>>OC1CCC2(CC1)OCCO2",
        "output": "91"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCC[N+](CCC)(CCC)CCC.CCOc1cc2c(cc1/C(C)=C(/F)CO)C(C(C)(C)C)=CCC2(C)C.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-]>>CCOc1cc2c(cc1/C(C)=C(/F)C=O)C(C(C)(C)C)=CCC2(C)C",
        "output": "183"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1ccc(-c2ccc(Cl)cc2)cn1.C=C(C)c1cc(I)ccc1OCCO.CCOC(C)=O>>C=C(C)c1cc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)ccc1OCCO",
        "output": "664"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)c1ccc(CCc2ccccc2)cc1Nc1ccc(-c2ccccc2)cc1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)c1ccc(CCc2ccccc2)cc1Nc1ccc(-c2ccccc2)cc1",
        "output": "752"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc2c(Cl)nc(Nc3cc(C)[nH]n3)cc2c1.OB(O)c1ccc(F)cc1F>>COc1ccc2c(-c3ccc(F)cc3F)nc(Nc3cc(C)[nH]n3)cc2c1",
        "output": "865"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C1(N)Cc2ccccc2C1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cccc(C(=O)O)c1C(=O)C(C)C.F[P-](F)(F)(F)(F)F>>CCOC(=O)C1(NC(=O)c2cccc(C)c2C(=O)C(C)C)Cc2ccccc2C1",
        "output": "709"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COc1cc(F)c(C(C)C)cc1B(O)O.C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1Cc1nc(Cl)ccc1Br.O=C([O-])[O-].[K+].[K+]>>COc1cc(F)c(C(C)C)cc1-c1ccc(Cl)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C",
        "output": "833"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CNC(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(F)cc1.O.O=C(Cl)c1cccc2ccccc12.O=C([O-])O.[Na+]>>CN(C(=O)c1cccc2ccccc12)C(Cc1ccc(C(F)(F)F)cc1)C(O)c1ccc(F)cc1",
        "output": "201"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)c1ccc(C(=O)Cl)cc1.ClCCl.Clc1ccc(CCN2CCNCC2)cc1.[Na+].[OH-]>>CN(C)c1ccc(C(=O)N2CCN(CCc3ccc(Cl)cc3)CC2)cc1",
        "output": "201"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(NC(=O)C(C)N(C)C(=O)OC(C)(C)C)C(=O)N1CCC2C1C(c1c[nH]c3cc(F)ccc13)CN2S(C)(=O)=O.ClCCl.O=C(O)C(F)(F)F>>CCC(NC(=O)C(C)NC)C(=O)N1CCC2C1C(c1c[nH]c3cc(F)ccc13)CN2S(C)(=O)=O",
        "output": "634"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.[OH-].[OH-].[Pd+2].c1ccc(CN2CCC3(CC2)CCN(C2CCC2)CC3)cc1>>C1CC(N2CCC3(CCNCC3)CC2)C1",
        "output": "84"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)CC1.CCOC(C)=O.ClCCl.Clc1nc(Cl)nc(N2CCOCC2)n1.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCC(Oc2nc(Cl)nc(N3CCOCC3)n2)CC1",
        "output": "213"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC.CN(C)C=O.CNCCO.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[Cl-].[K+].[K+]>>CN(CCO)c1ccc([N+](=O)[O-])cc1",
        "output": "26"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Oc1cccc2c1ccn2CC#N.CCO.Cl.[Ni]>>CC(C)(C)[Si](C)(C)Oc1cccc2c1ccn2CCN",
        "output": "246"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CN(C2CCNCC2)C1.CCc1ccc(C[C@@H](NC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc1CC>>CCc1ccc(C[C@@H](NC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCC3)CC2)cc1CC",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCOC(C)=O.CO.CO.NC(=O)c1ccc(F)c2c1CC(N)CO2.O=CCCc1c[nH]c2cc(F)ccc12.[BH3-]C#N.[Na+]>>NC(=O)c1ccc(F)c2c1CC(NCCCc1c[nH]c3cc(F)ccc13)CO2",
        "output": "426"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCCOc1ccc2c(c1CN1CCN(C(=O)OC(C)(C)C)CC1)O/C(=C\\c1c[nH]c3ccccc13)C2=O.Cl.ClCCl>>CCCOc1ccc2c(c1CN1CCNCC1)O/C(=C\\c1c[nH]c3ccccc13)C2=O",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1c(C)cccc1Cl.ClC(Cl)(Cl)Cl.ClCCl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)c1c(Cl)cccc1CBr",
        "output": "545"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc2[nH]cc(CC(=O)O)c2n1.Cn1nc(NS(C)(=O)=O)c2c(Cl)ccc(-c3ccc(C#CC(C)(C)O)nc3[C@@H](N)Cc3cc(F)cc(F)c3)c21.O=C(Cn1nc(C(F)F)c2c1C(F)(F)CCC2(F)F)N[C@@H](Cc1cc(F)cc(F)c1)c1ncc(Br)cc1Br>>COc1ccc2[nH]cc(CC(=O)N[C@@H](Cc3cc(F)cc(F)c3)c3nc(C#CC(C)(C)O)ccc3-c3ccc(Cl)c4c(NS(C)(=O)=O)nn(C)c34)c2n1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)c1ccncc1.Cl.N#Cc1ccc(-c2nc(NCCN)ncc2-c2ncc[nH]2)cc1.O.O=C(O)c1cccc([N+](=O)[O-])c1.On1nnc2ccccc21>>N#Cc1ccc(-c2nc(NCCNC(=O)c3cccc([N+](=O)[O-])c3)ncc2-c2ncc[nH]2)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.Cc1ccccc1.O=C(Cl)c1ccccc1.OCCc1ccccc1>>O=C(OCCc1ccccc1)c1ccccc1",
        "output": "51"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CS(=O)(=O)Cl.NCc1ccc(C(=O)O)cc1.[Na+].[OH-]>>CS(=O)(=O)NCc1ccc(C(=O)O)cc1",
        "output": "742"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)c1nc(Cl)c(C(F)(F)F)nc1N.Cl.O.[Na+].[OH-]>>Nc1nc(C(F)(F)F)c(Cl)nc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1ccc(C(=O)N2CCC(N)CC2)cc1.CC(C)c1ccc(S(=O)(=O)c2ccccc2)cc1S(=O)(=O)Cl.CCN(C(C)C)C(C)C.Cl>>CC(C)c1ccc(S(=O)(=O)c2ccccc2)cc1S(=O)(=O)NC1CCN(C(=O)c2ccc(C(C)(C)C)cc2)CC1",
        "output": "43"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCOC(=O)c1n[nH]cc1[N+](=O)[O-].COc1ccc(CCl)cc1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1nn(Cc2ccc(OC)cc2)cc1[N+](=O)[O-]",
        "output": "842"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCCN1CCCCC1.O.O=C(O)c1ccc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)cc1>>O=C(NCCN1CCCCC1)c1ccc(-c2ccc3nnn(Cc4ccc5ncccc5c4)c3n2)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(NC(=O)OCc2ccccc2)CCN(C(=O)OC(C)(C)C)CC1.CCO.[Pd]>>CC1(N)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "574"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.C[C@@H](Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc4cccc(F)c4)c3)c12)C(=O)O>>C[C@@H](Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc4cccc(F)c4)c3)c12)C(=O)N1CCOCC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)OC(=O)N(Cc1ccccc1)C12CCC(CO)(CC1)CC2.ClCCl>>CC(C)(C)OC(=O)N(Cc1ccccc1)C12CCC(C=O)(CC1)CC2",
        "output": "142"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN(C)C=O.NCC1CCCCC1.O=C(Cl)C(=O)Cl.O=C(O)c1cccc(-c2ccccc2)c1>>O=C(NCC1CCCCC1)c1cccc(-c2ccccc2)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CNC(=O)c1ccccc1Nc1nc(Cl)ncc1Cl.COCCO.COc1cc(N2CCOCC2)ccc1N.Cl.Cl.Cl.[Na+].[OH-]>>CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.Cc1ccccc1.Cc1oc(-c2ccc(Br)cc2)nc1CCO.II.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccncc1>>Cc1oc(-c2ccc(Br)cc2)nc1CCI",
        "output": "670"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCCCCC.CCOC(C)=O.CCOc1cccc(C(C)(C)C(C)=O)c1.O=C(O)C(F)(F)F.O=C1CCC(=O)N1I>>CCOc1cc(C(C)(C)C(C)=O)ccc1I",
        "output": "834"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(N)c1nc2nc(Cl)ccc2[nH]1.CCN(C(C)C)C(C)C.CCO.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1cc(C(=O)O)ccc1C(=O)N1CCCC1.ClCCl.ClCl.F[B-](F)(F)F>>Cc1cc(C(=O)NC(C)c2nc3nc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1",
        "output": "902"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCN(CC(=O)OCc1ccccc1)C(=O)c1cc2ccccc2cc1NC(=O)Nc1c(Cl)cccc1Cl.CCO.[Pd]>>CCCCN(CC(=O)O)C(=O)c1cc2ccccc2cc1NC(=O)Nc1c(Cl)cccc1Cl",
        "output": "186"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.CO.COc1c(F)cc(C(=O)O)cc1F.Cc1ccc2nc(-c3ccc(N)cc3)cn2c1.ClCCl.O=S(Cl)Cl.c1ccncc1>>COc1c(F)cc(C(=O)Nc2ccc(-c3cn4cc(C)ccc4n3)cc2)cc1F",
        "output": "50"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)CCNC1CCN(C(=O)OC(C)(C)C)CC1.CN(C)C=O.ClCCCl.O.O=Cc1ccccc1Br.[Na+]>>CC(C)(C)CCN(Cc1ccccc1Br)C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.Cl.ClCCl.O=C(O)CCOCCOCCOCCN1C(=O)C=CC1=O.O=C([O-])O.Oc1c(F)c(F)c(F)c(F)c1F.[Na+]>>O=C(CCOCCOCCOCCN1C(=O)C=CC1=O)Oc1c(F)c(F)c(F)c(F)c1F",
        "output": "108"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CNc1nccc(-c2cccnc2Oc2c(C)ccc3c(Cl)nccc23)n1.CO.Cl.N.Nc1cccc(OC(F)(F)F)c1>>CNc1nccc(-c2cccnc2Oc2c(C)ccc3c(Nc4cccc(OC(F)(F)F)c4)nccc23)n1",
        "output": "434"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC[C@@H]1CCCN1C(=O)CCl>>COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC[C@@H]1CCCN1C(=O)CN1CCCC1",
        "output": "340"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.O=C(O)C12CC3(O)CC(O)(CC(O)(C3)C1)C2.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCC12CC3(O)CC(O)(CC(O)(C3)C1)C2",
        "output": "231"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)CBr.CCOC(C)=O.CN(C)C=O.COc1ccc(C=O)c(O)c1.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)COc1cc(OC)ccc1C=O",
        "output": "123"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.CS(C)=O.Cc1cc(C)c(CNC(=O)c2cc(-c3cnc(S(C)(=O)=O)nc3)cc(-c3c(C)cnn3C)c2C)c(=O)[nH]1>>Cc1cc(C)c(CNC(=O)c2cc(-c3cnc(N4CCOCC4)nc3)cc(-c3c(C)cnn3C)c2C)c(=O)[nH]1",
        "output": "679"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCOC(C)=O.CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.CNc1ncc2cc(-c3c(C)ccc4c(Cl)nccc34)ccc2n1.C[Si](C)(C)[N-][Si](C)(C)C.Nc1cccc(C(F)(F)F)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Li+].[Pd].[Pd]>>CNc1ncc2cc(-c3c(C)ccc4c(Nc5cccc(C(F)(F)F)c5)nccc34)ccc2n1",
        "output": "434"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(CN1CCNCC1)N1CCOCC1.O=C(O)Cc1csc(NC(=O)c2ccc(Cl)cc2)n1>>O=C(Nc1nc(CC(=O)N2CCN(CC(=O)N3CCOCC3)CC2)cs1)c1ccc(Cl)cc1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C)n1ccc2ccc(OCc3cc(-c4ccc(OC(F)(F)F)cc4)nn3C)cc21.[Li+].[OH-]>>CC(C(=O)O)n1ccc2ccc(OCc3cc(-c4ccc(OC(F)(F)F)cc4)nn3C)cc21",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)OC(C)C.CN(CC(=O)OC(C)(C)C)C(=O)CCc1cccc(-c2nc(=O)c3ccccc3s2)n1.O=C(O)C(F)(F)F>>CN(CC(=O)O)C(=O)CCc1cccc(-c2nc(=O)c3ccccc3s2)n1",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN.CN1CCCC1=O.Cl.O=C(O)c1ccc(S(=O)(=O)c2ccc(/C=C/c3ccc(F)cc3F)cc2)cc1.O=C(n1ccnc1)n1ccnc1>>CNC(=O)c1ccc(S(=O)(=O)c2ccc(/C=C/c3ccc(F)cc3F)cc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].CCOCC.N[C@@H]1Cc2cccc3c2[C@@H](C1)CN3C(=O)c1ccccc1.O.[Na+].[Na+].[OH-]>>N[C@@H]1Cc2c(Br)ccc3c2[C@@H](C1)CN3C(=O)c1ccccc1",
        "output": "98"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CO.Cn1nnn(-c2cccc([N+](=O)[O-])c2)c1=O.[Pd]>>Cn1nnn(-c2cccc(N)c2)c1=O",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)Cn1c(CCCCN)nc2c(N)nc3ccccc3c21.CCN(CC)CC.Cl.ClCCl.O=C(Cl)c1ccccc1>>CC(C)Cn1c(CCCCNC(=O)c2ccccc2)nc2c(N)nc3ccccc3c21",
        "output": "271"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc(N2CCN[C@@H](Cc3ccccc3)C2)cc1OC1CCCC1.F[P-](F)(F)(F)(F)F>>COc1ccc(N2CCN(C(=O)CNC(=O)OC(C)(C)C)[C@@H](Cc3ccccc3)C2)cc1OC1CCCC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc(N)cc2)CC1.COCc1c(C(=O)O)oc2ccccc12>>COCc1c(C(=O)Nc2ccc(N3CCN(C(=O)OC(C)(C)C)CC3)cc2)oc2ccccc12",
        "output": "860"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)CCN(CCOC)CC3)ncc1Cl.O.[Li+].[OH-]>>COCCN1CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)O)n3)cc2CC1",
        "output": "5"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1COc1ccc(OCc2ccccc2)c(C(=O)Nc2cccnc2)c1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>O=C(Nc1cccnc1)c1cc(OC[C@@H]2CCCN2)ccc1OCc1ccccc1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)CN(C(=O)C(C)CSCC)C1CCCC1.Cl.[Na+].[OH-]>>CCSCC(C)C(=O)N(CC(=O)O)C1CCCC1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrC(Br)(Br)Br.CC#N.OCCc1coc2ccc(F)cc12.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Fc1ccc2occ(CCBr)c2c1",
        "output": "378"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1c(-c2ccc(N3CCOCC3)nc2)nc2cc(F)cc(F)c2c1Cl.Cc1ccccc1.Nc1cncc(N2CCOCC2)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1c(-c2ccc(N3CCOCC3)nc2)nc2cc(F)cc(F)c2c1Nc1cncc(N2CCOCC2)c1",
        "output": "859"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCCN(C)C1=O.ClCCl.OCc1cc2c(Nc3cccc(Cl)c3)ncnc2[nH]1.[Mn+4].[O-2].[O-2]>>O=Cc1cc2c(Nc3cccc(Cl)c3)ncnc2[nH]1",
        "output": "263"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1nc(Br)cc2c(-c3cc([N+](=O)[O-])ccc3F)cn(C)c12.CS(C)=O.O=C([O-])[O-].Oc1ccc(F)cc1F.[Cs+].[Cs+]>>COc1nc(Br)cc2c(-c3cc([N+](=O)[O-])ccc3Oc3ccc(F)cc3F)cn(C)c12",
        "output": "564"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CSCCNCCn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1.NCc1ccccn1.O=C(Nc1cn(CCBr)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12>>O=C(Nc1cn(CCNCc2ccccn2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12",
        "output": "147"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CCC1CCc2cc(O)ccc2C1.O=[N+]([O-])O>>CCC1CCc2cc(O)c([N+](=O)[O-])cc2C1",
        "output": "21"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.FC1CNC1.F[P-](F)(F)(F)(F)F.O.O=C(O)c1cnc2c(-c3cnco3)cc(C(F)(F)F)cn12>>O=C(c1cnc2c(-c3cnco3)cc(C(F)(F)F)cn12)N1CC(F)C1",
        "output": "729"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.ClCCl.N[C@@H]1C(=O)N[C@@H]1CF.O=C(O)C(=NOC(F)F)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>O=C(N[C@@H]1C(=O)N[C@@H]1CF)C(=NOC(F)F)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1",
        "output": "587"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)Cc1cc(C)c(C(=O)c2ccc(Cl)cc2Cl)n1C.[Na+].[OH-]>>Cc1cc(CC(=O)O)n(C)c1C(=O)c1ccc(Cl)cc1Cl",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)CC1CCC(CO[Si](C(C)C)(C(C)C)C(C)C)CC1.[Na+].[OH-]>>CC(C)[Si](OCC1CCC(CC(=O)O)CC1)(C(C)C)C(C)C",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cc1cc([N+](=O)[O-])c(O)c(F)c1F.[H][H].[Pd]>>Cc1cc(N)c(O)c(F)c1F",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)CCC(=O)Nc1ccc(COCc2ccc(-c3ccccc3)cc2)cn1.Cl.[Na+].[OH-]>>O=C(O)CCC(=O)Nc1ccc(COCc2ccc(-c3ccccc3)cc2)cn1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(-c2cc(Cl)nnc2-c2ccc(OC)c(OC)c2)cc1.Oc1ccc(F)cc1F>>COc1ccc(-c2cc(Oc3ccc(F)cc3F)nnc2-c2ccc(OC)c(OC)c2)cc1",
        "output": "603"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCCCOc1cccc(CCN)c1.CCCOc1cccc(CCN)c1.CCN(CC)CC.O.O=C(Cl)C=Cc1ccccc1Cl>>CCCOc1cccc(CCNC(=O)C=Cc2ccccc2Cl)c1",
        "output": "298"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COCCO.COCCOC.Clc1ccc(Br)cn1.[H-].[Na+]>>COCCOc1ccc(Br)cn1",
        "output": "433"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(Cl)ccc1N.ClCCl.O=S(=O)(Cl)c1cccs1.c1ccncc1>>COc1cc(Cl)ccc1NS(=O)(=O)c1cccs1",
        "output": "861"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)O.CO.C[Si](C)(C)C=[N+]=[N-]>>COC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)OC(C)(C)C",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.N#CCBr.O=C(NC1CCNCC1)c1ccc(/C=C/C(c2cc(Cl)c(Cl)c(Cl)c2)C(F)(F)F)cc1Br>>N#CCN1CCC(NC(=O)c2ccc(/C=C/C(c3cc(Cl)c(Cl)c(Cl)c3)C(F)(F)F)cc2Br)CC1",
        "output": "880"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCOc1nc(N)c2nc(OC)n(CCCC3CCCCN3)c2n1.CCCCOc1nc(N)c2nc(OC)n(CCCCCC3CCCN(C(=O)OCc4ccccc4)C3)c2n1>>CCCCOc1nc(N)c2nc(OC)n(CCCCCC3CCCNC3)c2n1",
        "output": "428"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN1CCOCC1.Cl.F[P-](F)(F)(F)(F)F.NCc1ccco1.O=C(O)c1cc([N+](=O)[O-])ccc1F.On1nnc2ccccc21>>O=C(NCc1ccco1)c1cc([N+](=O)[O-])ccc1F",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)c1nc2c(C(F)(F)F)ccnn2c1-c1cccc(O)c1.CCS(=O)(=O)c1cccc(Br)c1>>CCS(=O)(=O)c1cccc(Oc2cccc(-c3c(C(C)C)nc4c(C(F)(F)F)ccnn34)c2)c1",
        "output": "238"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1cncc(C(=O)N=[S@@](C)(=O)c2ccccc2)c1.Cc1cc(I)ccc1O>>Cc1cc(C#Cc2cncc(C(=O)N=[S@@](C)(=O)c3ccccc3)c2)ccc1O",
        "output": "664"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN1CCNCC1.ClCCl.O=C([O-])O.O=[N+]([O-])c1ccc(CBr)c(Cl)c1.[Na+]>>CN1CCN(Cc2ccc([N+](=O)[O-])cc2Cl)CC1",
        "output": "248"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(=O)c1cc(CN)cc(C(=O)OCC)c1.CS(=O)(=O)Cl.ClCCl>>CCOC(=O)c1cc(CNS(C)(=O)=O)cc(C(=O)OCC)c1",
        "output": "742"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.COc1ccc(Cl)cc1-c1ccc(C(=O)N2CCCC2)c(Cl)c1.ClCCl>>O=C(c1ccc(-c2cc(Cl)ccc2O)cc1Cl)N1CCCC1",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)C[C@@H]1COc2cc(OCc3cccc(-c4c(C)c(Cl)c(OCCCS(C)(=O)=O)c(Cl)c4C)c3)ccc21.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>Cc1c(Cl)c(OCCCS(C)(=O)=O)c(Cl)c(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCI.OCc1cc(Br)cc(Br)c1.[H-].[Na+]>>CCOCc1cc(Br)cc(Br)c1",
        "output": "307"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COCC1(CN(C(=O)C(F)(F)F)[C@@H]2C[C@H]2c2ccccc2)CCN(C(=O)OC(C)(C)C)CC1.Cl.ClCCl>>COCC1(CN(C(=O)C(F)(F)F)[C@@H]2C[C@H]2c2ccccc2)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.C[O-].Clc1ncnc2ccc(I)cc12.[Na+]>>COc1ncnc2ccc(I)cc12",
        "output": "461"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.ClCCl.N[C@H]1CCS(=O)(=O)C1.O.O=S(=O)(Cl)c1ccc(Br)cc1>>O=S1(=O)CC[C@H](NS(=O)(=O)c2ccc(Br)cc2)C1",
        "output": "43"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cc1cc(C)c(C(C)(C)CC(=O)O)c(OP(=O)(OCc2ccccc2)OCc2ccccc2)c1.Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3cc(Cl)ccc32)c(C)c1.Cl.ClCCl.O>>Cc1cc(C)c(C(C)(C)CC(=O)OC2CCCN(C(=O)c3ccc(NC(=O)c4ccccc4C)cc3C)c3ccc(Cl)cc32)c(OP(=O)(OCc2ccccc2)OCc2ccccc2)c1",
        "output": "17"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCBr.CO.Cc1ccc(O)c2c1CCC2=O.[K+].[OH-]>>C=CCOc1ccc(C)c2c1C(=O)CC2",
        "output": "77"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CO.Cc1ccc(N(C(=O)c2ccco2)C2CCN(CCC3(CCNC(=O)OC(C)(C)C)CCCCC3)CC2)nc1.Cl>>Cc1ccc(N(C(=O)c2ccco2)C2CCN(CCC3(CCN)CCCCC3)CC2)nc1",
        "output": "538"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COc1ccc2ncc(Cl)c(C(CO)CN3CCC(NC(=O)OC(C)(C)C)CC3)c2n1.Cl.ClCCl>>COc1ccc2ncc(Cl)c(C(CO)CN3CCC(N)CC3)c2n1",
        "output": "538"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CCc1nc2ccccc2[nH]1.Cn1c(CN2C[C@@H]3C[C@H]2CN3S(C)(=O)=O)nc2c(N3CCOCC3)nc(Cl)nc21.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3C[C@@H]4C[C@H]3CN4S(C)(=O)=O)n(C)c2n1",
        "output": "916"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#CCCCCCCCCCC.C1CCOC1.Fc1ccccc1Br.[Cu]I>>CCCCCCCCCCC#Cc1ccccc1F",
        "output": "659"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1ccc([C@H](C)N)cc1.Cl.O=C(O)c1cc(Cl)cnc1COc1ccc(F)cc1>>COC(=O)c1ccc([C@H](C)NC(=O)c2cc(Cl)cnc2COc2ccc(F)cc2)cc1",
        "output": "790"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCNCc1cc(C)cnc1Cl.ClCCl>>CCN(Cc1cc(C)cnc1Cl)C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1nn2c(=O)[nH]c3ccccc3c2c1C.[K+].[OH-]>>Cc1c(C(=O)O)nn2c(=O)[nH]c3ccccc3c12",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(O)CCn1ccc2cc(OCc3ccccc3)ccc21.CCN(CC)CC.CO.[Pd]>>CC(C)(O)CCn1ccc2cc(O)ccc21",
        "output": "23"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)n1nc(-c2cc3ccc(OCCBr)cc3n2C(=O)OC(C)(C)C)c2cc(OCc3ccccc3)ccc21.CCNCC.O=C([O-])[O-].[Cs+].[Cs+].[I-].[K+]>>CCN(CC)CCOc1ccc2cc(-c3nn(C(=O)OC(C)(C)C)c4ccc(OCc5ccccc5)cc34)n(C(=O)OC(C)(C)C)c2c1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cl.ClCCl.Nc1ccc(Cl)cc1.O=[N+]([O-])c1ccccc1F.[F-].[K+]>>O=[N+]([O-])c1ccccc1Nc1ccc(Cl)cc1",
        "output": "609"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)Cc1cc2ccc(Cl)cc2c(-c2ccc(S(=O)(=O)c3ccc(F)cc3F)cc2)c1C.O.O.[Li+].[OH-]>>Cc1c(CC(=O)O)cc2ccc(Cl)cc2c1-c1ccc(S(=O)(=O)c2ccc(F)cc2F)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(N)C(F)(F)F.CCN(CC)CC.ClCCl.O=C(Cl)c1cccc(CCl)c1>>CC(C)(NC(=O)c1cccc(CCl)c1)C(F)(F)F",
        "output": "271"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(C)=O.NN.O.O=C(OCc1ccccc1)C(Cc1ccccc1)ON1C(=O)c2ccccc2C1=O>>NOC(Cc1ccccc1)C(=O)OCc1ccccc1",
        "output": "452"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)c1cccc(C(C)C)c1N.CCCCCCCCCCCCc1nnn(C(CCCCC)C(=O)O)n1.CCCCCCCCCCc1nnn(CC(=O)O)n1.COc1cc(OC)c(N)c(OC)c1>>CCCCCCCCCCCCc1nnn(C(CCCCC)C(=O)Nc2c(OC)cc(OC)cc2OC)n1",
        "output": "646"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)CI.COc1ccc(-c2n[nH]c(=O)cc2-c2ccc(OC)c(F)c2)cc1>>COc1ccc(-c2nn(CC(C)C)c(=O)cc2-c2ccc(OC)c(F)c2)cc1",
        "output": "346"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCC1=CNC2=C(CC(C)CC2)C1OCc1ccc(-c2ccccc2C(=O)OC)cc1.CCCCc1cn(Cc2ccc(-c3ccccc3C(=O)OC)cc2)c2c(c1=O)CCCC2>>CCCCC1=CNC2=C(CC(C)CC2)C1OCc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1cccs1.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)NCc1cccs1",
        "output": "631"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)(C)N.O=C1c2ccccc2C(=O)N1c1c(F)c(F)nc(F)c1Cl>>CC(C)(C)Nc1nc(F)c(Cl)c(N2C(=O)c3ccccc3C2=O)c1F",
        "output": "810"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1ccc2oc(Cc3ccccc3)cc2c1.C1COCCO1.O.O=C([O-])[O-].O=Cc1ccc(B(O)O)c(F)c1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=Cc1ccc(-c2ccc3oc(Cc4ccccc4)cc3c2)c(F)c1",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "B.C1CCOC1.C1CCOC1.O=C(O)c1cc([N+](=O)[O-])ccc1Br>>O=[N+]([O-])c1ccc(Br)c(CO)c1",
        "output": "72"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COCCOc1ccc([N+](=O)[O-])cn1.[Pd]>>COCCOc1ccc(N)cn1",
        "output": "269"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CNC(=O)c1sccc1Nc1nc(Cl)ncc1Cl.Nc1ccc2c(c1)-n1ccnc1CCC2>>CNC(=O)c1sccc1Nc1nc(Nc2ccc3c(c2)-n2ccnc2CCC3)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "FC(F)(F)c1cc(Cl)ccc1CBr.O=Cc1ccc2[nH]nc(Br)c2c1>>O=Cc1ccc2c(c1)c(Br)nn2Cc1ccc(Cl)cc1C(F)(F)F",
        "output": "635"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CN.CS(=O)(=O)c1nccc(Oc2ccc3[nH]c(Nc4ccc(Cl)c(C(F)(F)F)c4)nc3c2)n1>>CNc1nccc(Oc2ccc3[nH]c(Nc4ccc(Cl)c(C(F)(F)F)c4)nc3c2)n1",
        "output": "629"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOc1c(-c2n[nH]c3ccc(C(C)=CC(=O)OC)cc23)cc(C(C)C)cc1C(C)C.CO.Cl.[Na+].[OH-]>>CCOc1c(-c2n[nH]c3ccc(C(C)=CC(=O)O)cc23)cc(C(C)C)cc1C(C)C",
        "output": "58"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1[C@H]([C@@H](C(=O)O)c2ccc(Cl)cc2)CCC1(C)C.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.C[C@@H]1CCc2ncnc(C3CCNCC3)c21.ClCCl.F[P-](F)(F)(F)(F)F>>C[C@@H]1CCc2ncnc(C3CCN(C(=O)[C@@H](c4ccc(Cl)cc4)[C@@H]4CCC(C)(C)N4C(=O)OC(C)(C)C)CC3)c21",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.COc1ccc(Cn2ccc(C(C)(C)c3ccc(N4CCc5nc(OC)nc(N)c5C4=O)cc3)n2)cc1.[H][H].[Pd]>>COc1nc(N)c2c(n1)CCN(c1ccc(C(C)(C)c3cc[nH]n3)cc1)C2=O",
        "output": "940"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCc1ccc(Cl)c(Cl)c1.OCCNCCO>>OCCN(CCO)Cc1ccc(Cl)c(Cl)c1",
        "output": "156"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O.CC1(C)CC(N)C(O)CN(S(=O)(=O)c2ccccn2)C1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.Cl.F[P-](F)(F)(F)(F)F>>CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)NC1CC(C)(C)CN(S(=O)(=O)c2ccccn2)CC1O",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)CN1CCN(C(=O)C2=C(C(C)C)N3C(=N[C@@H](c4ccc(Cl)cc4)[C@H]3c3ccc(Cl)cc3)S2)CC1=O.CO.Cl.[Na+].[OH-]>>CC(C)C1=C(C(=O)N2CCN(CC(=O)O)C(=O)C2)SC2=N[C@@H](c3ccc(Cl)cc3)[C@@H](c3ccc(Cl)cc3)N21",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOc1nc2ccc(F)cc2n1-c1cccc(C(=O)OC)c1C.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>CCOc1nc2ccc(F)cc2n1-c1cccc(CO)c1C",
        "output": "444"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C1COCCO1.COC(=O)[C@@H]1C[C@H](Oc2ccc3c(Nc4cccc(Cl)c4F)ncnc3c2)CN1C.Cl.O.O.[Li+].[OH-]>>CN1C[C@@H](Oc2ccc3c(Nc4cccc(Cl)c4F)ncnc3c2)C[C@H]1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)[C@@H](C(=O)O)N1Cc2ccc(-c3ccc(NC(=O)c4ccccc4)cc3)cc2C1=O.COC(=O)C1(N2Cc3ccc(-c4ccc(NC(=O)c5ccc(C(F)(F)F)cc5)cc4)cc3C2=O)CCC1>>O=C(Nc1ccc(-c2ccc3c(c2)C(=O)N(C2(C(=O)O)CCC2)C3)cc1)c1ccc(C(F)(F)F)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CS(C)=O.Cc1cc(CO)cc(C(=O)O)c1.ClCCl.O=C(Cl)C(=O)Cl>>Cc1cc(C=O)cc(C(=O)O)c1",
        "output": "179"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=[N+]([O-])c1ccc(CCCN2CCC(=C3c4ccccc4C=Cc4ccccc43)CC2)cc1.[Zn]>>Nc1ccc(CCCN2CCC(=C3c4ccccc4C=Cc4ccccc43)CC2)cc1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc2c(-c3cc4c(CN5CCC(O)CC5)ccnc4n3S(=O)(=O)c3ccc(C)cc3)cn(C)c2cc1OC.[K+].[OH-]>>COc1cc2c(-c3cc4c(CN5CCC(O)CC5)ccnc4[nH]3)cn(C)c2cc1OC",
        "output": "949"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CC2C(C1)C2n1cnnn1.Cl>>c1nnnn1C1C2CNCC21",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cc1ccccc1.O[C@H]1CCN(Cc2ccccc2)C1>>CS(=O)(=O)O[C@H]1CCN(Cc2ccccc2)C1",
        "output": "0"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COc1ccc(CCN(C)CCCN)cc1OC.O=C1CCCC1.O=[Pt]>>COc1ccc(CCN(C)CCCNC2CCCC2)cc1OC",
        "output": "236"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.[N-]=[N+]=NCc1ccc2occc2c1.[Ni]>>NCc1ccc2occc2c1",
        "output": "562"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.C[C@H](O)[C@](O)(Cn1cncn1)c1ccc(F)cc1F>>C[C@H](OS(C)(=O)=O)[C@](O)(Cn1cncn1)c1ccc(F)cc1F",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.C[C@H]1C[C@@H](NC(=O)OC(C)(C)C)CN(c2ccc(C#N)c3ncccc23)C1.Cl.O.O=S([O-])([O-])=S.OO.[Na+].[Na+].[Na+].[OH-]>>C[C@H]1C[C@@H](NC(=O)OC(C)(C)C)CN(c2ccc(C(N)=O)c3ncccc23)C1",
        "output": "677"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ncc(Br)cc1-c1nc2c(F)cccc2o1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.[K+]>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1ncc(B2OC(C)(C)C(C)(C)O2)cc1-c1nc2c(F)cccc2o1",
        "output": "943"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.O.O=C1Nc2ccccc2Oc2ccccc21.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>c1ccc2c(c1)CNc1ccccc1O2",
        "output": "215"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)CC(=O)Cl.COc1ccccc1.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(C(=O)CC(C)C)cc1",
        "output": "31"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1nc2cc(C)c(C)cc2nc1Cl.CO.O.O=C([O-])[O-].[Na+].[Na+]>>Cc1cc2nc(Cl)c(C(=O)O)nc2cc1C",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.O=CCc1ccc([N+](=O)[O-])cc1F.[Na+]>>O=[N+]([O-])c1ccc(CCN2CCCC2)c(F)c1",
        "output": "484"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc(-c2ccncc2)c(C(=O)O)c1.Cl.F[P-](F)(F)(F)(F)F.O.OC1(Cc2ccccc2)CCNCC1>>Cc1ccc(-c2ccncc2)c(C(=O)N2CCC(O)(Cc3ccccc3)CC2)c1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CO.COc1c(C#C[Si](C)(C)C)cc(C(C)(C)C)cc1[N+](=O)[O-].O.O=C([O-])[O-].[K+].[K+]>>C#Cc1cc(C(C)(C)C)cc([N+](=O)[O-])c1OC",
        "output": "337"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)C(C)(C)Br.O=C([O-])[O-].O=Cc1ccc(O)cc1.[K+].[K+]>>CCOC(=O)C(C)(C)Oc1ccc(C=O)cc1",
        "output": "305"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNCCCCCCNC.ClCCl>>CNCCCCCCN(C)C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc([C@H](C)N)cc1.O=C(O)Cn1nnc2cc(Cl)ccc2c1=O>>Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(Cl)ccc3c2=O)cc1",
        "output": "599"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.Cc1ccc2c(c1)c1c(n2CC(O)c2ccncc2)CCNC1.O.O=C([O-])[O-].OCCBr.[K+].[K+]>>Cc1ccc2c(c1)c1c(n2CC(O)c2ccncc2)CCN(CCO)C1",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CN(C)C=O.Nc1cccc2cnccc12.O=C(Nc1cn(C2CCC2)cn1)Oc1ccccc1>>O=C(Nc1cn(C2CCC2)cn1)Nc1cccc2cnccc12",
        "output": "948"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=S(CCCNCCO)CCC(F)(F)F.Oc1ccc2c(c1)CCCC(c1ccccc1)=C2CCCCCCBr>>O=S(CCCN(CCO)CCCCCCC1=C(c2ccccc2)CCCc2cc(O)ccc21)CCC(F)(F)F",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)O.CC(Cl)C(=O)Cl.CCN(CC)CC.OCCC(CO)NCc1ccccc1>>CC(Cl)C(=O)N(Cc1ccccc1)C(CO)CCO",
        "output": "240"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.O=C(Cl)C(=O)Cl.O=C(O)c1ccc(I)cc1>>O=C(Cl)c1ccc(I)cc1",
        "output": "448"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CNC1.COC(=O)[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1ccc(Cl)nc1)C2>>COC(=O)[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1ccc(N3CCC3)nc1)C2",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1c(-c2ccc(F)cc2)nn2cc(C(F)(F)F)ccc12.COC(OC)N(C)C>>CN(C)/C=C/C(=O)c1c(-c2ccc(F)cc2)nn2cc(C(F)(F)F)ccc12",
        "output": "898"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[Si](C)(C)OC1CCN(Cc2ccccc2)CC1.CO.[H][H].[OH-].[OH-].[Pd+2]>>CC(C)(C)[Si](C)(C)OC1CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)Nc1nc(OC)ns1.[Na+].[OH-]>>COc1nsc(N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)O)n1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CI.Cc1c(O)cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)c(=O)n1-c1cccc(C(F)(F)F)c1.O=C([O-])[O-].[K+].[K+]>>COc1cc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)c(=O)n(-c2cccc(C(F)(F)F)c2)c1C",
        "output": "661"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.CS(=O)(=O)c1ccc(Oc2ccc(N)nc2CN2CCCC2=O)cn1.II.O=C([O-])O.O=S(=O)([O-])[O-].O=S([O-])([O-])=S.[Ag+2].[Na+].[Na+].[Na+]>>CS(=O)(=O)c1ccc(Oc2cc(I)c(N)nc2CN2CCCC2=O)cn1",
        "output": "850"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)NC(C)C.CN(C)C=O.O=C(Cl)Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1.c1cncc(CN(C2CCNCC2)C2CC2)c1>>O=C(Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1)N1CCC(N(Cc2cccnc2)C2CC2)CC1",
        "output": "219"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCOC(C)=O.Cl.ClCCl.O=C1NCCC12CCCNC2.O=S(=O)(Cl)c1ccc(Br)c(C(F)(F)F)c1>>O=C1NCCC12CCCN(S(=O)(=O)c1ccc(Br)c(C(F)(F)F)c1)C2",
        "output": "99"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1ccc(Nc2nccc(-c3cccnc3)n2)cc1.CCOC(=O)c1ccc(Nc2nccc(-n3ccnc3)n2)cc1>>O=C(O)c1ccc(Nc2nccc(-n3ccnc3)n2)cc1",
        "output": "5"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.COC(=O)C(C)(Cc1ccc(O)c(O)c1)NN>>CCOC(=O)C(C)(Cc1ccc(O)c(O)c1)NN",
        "output": "289"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.O=C([C@H]1C[C@@H]1c1ccc(Br)cc1)N1CCCC1>>Brc1ccc([C@H]2C[C@@H]2CN2CCCC2)cc1",
        "output": "112"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C=C(C)C1NC(=O)CC(c2cc(Cl)ccc2OCC(=O)OC)C12C(=O)Nc1cc(Cl)ccc12.[Na+].[OH-]>>C=C(C)C1NC(=O)CC(c2cc(Cl)ccc2OCC(=O)O)C12C(=O)Nc1cc(Cl)ccc12",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CNOC.Cl.Cl.ClCCl.O=C1CCC(C(=O)O)C1.On1nnc2ccccc21>>CON(C)C(=O)C1CCC(=O)C1",
        "output": "54"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CO.CS(=O)(=O)OCCCN1C(=O)C2CCCCC2C1=O.Fc1ccc(-c2nc(C3CCNCC3)n3ccccc23)cc1>>O=C1C2CCCCC2C(=O)N1CCCN1CCC(c2nc(-c3ccc(F)cc3)c3ccccn23)CC1",
        "output": "496"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(C)c(C(=O)CCCCCCCCC(=O)O)c(O)c1OC.Cc1ccccc1.Cl.O>>COc1cc(C)c(CCCCCCCCCC(=O)O)c(O)c1OC",
        "output": "92"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1Nc1cnc(C#N)c(Cl)n1.Nc1cccc(-n2nccn2)c1.O=C([O-])[O-].[K+].[K+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1Nc1cnc(C#N)c(Nc2cccc(-n3nccn3)c2)n1",
        "output": "780"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#CCNC(=O)c1cccc(F)c1Nc1nc(Cl)ncc1Cl.Nc1ccc2c(c1)CCN(C(=O)C1COCCO1)CC2.O=CC1COCCO1>>C#CCNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)CCN(C(=O)C2COCCO2)CC3)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc(OC)c(F)c(N2Cc3cnc4c(ccn4COCC[Si](C)(C)C)c3C(C)(C)C2=O)c1F.ClCCl.O=C(O)C(F)(F)F>>COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3C(C)(C)C2=O)c1F",
        "output": "897"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)CCCC(=O)c1cn(-c2cccnc2)c2ccccc12.[Na+].[OH-]>>O=C(O)CCCC(=O)c1cn(-c2cccnc2)c2ccccc12",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1nc(NC[C@H](NS(=O)(=O)c2cccc3ccccc23)C(=O)OC(C)(C)C)c2ccn(CCCC(=O)NC3=NCCCN3)c2n1.ClCCl.O=C(O)C(F)(F)F>>Cc1nc(NC[C@H](NS(=O)(=O)c2cccc3ccccc23)C(=O)O)c2ccn(CCCC(=O)NC3=NCCCN3)c2n1",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CNCC(O)c1ccc(OC)cc1.Cc1c(CCl)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12.O>>COc1ccc(C(O)CN(C)Cc2sc3c(=O)c(C(=O)NCc4ccc(Cl)cc4)cn(C)c3c2C)cc1",
        "output": "639"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CN1CCC(CO)CC1.Oc1ccc(Cl)cc1I.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN1CCC(COc2ccc(Cl)cc2I)CC1",
        "output": "478"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.N#Cc1cc(-c2cc[n+]([O-])cc2)cnc1Cl>>N#Cc1cc(-c2cc[n+]([O-])cc2)cnc1N1CCOCC1",
        "output": "220"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1.O.O=C(O)c1ccc(-c2ncccn2)cc1.On1nnc2ccccc21>>O=C(NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1)c1ccc(-c2ncccn2)cc1",
        "output": "718"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)[C@@H]1C[C@H](c2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)c(F)c2)CN1C(=O)OC(C)(C)C.O.[Na+].[OH-]>>CC(C)(C)OC(=O)N1C[C@@H](c2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)c(F)c2)C[C@H]1C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.Cc1nc2cccc3n(CCCCCN)c(=O)c1n23.ClCCl.O=S(=O)(Cl)CC(F)(F)F>>Cc1nc2cccc3n(CCCCCNS(=O)(=O)CC(F)(F)F)c(=O)c1n23",
        "output": "493"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Nc1ccc(Cl)cc1C(F)(F)F.O=C(Cl)c1ccc(Cl)nc1>>O=C(Nc1ccc(Cl)cc1C(F)(F)F)c1ccc(Cl)nc1",
        "output": "642"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "OC(c1ccccc1)C(F)(F)F.Oc1nc(Cl)nc2cnccc12>>Oc1nc(OC(c2ccccc2)C(F)(F)F)nc2cnccc12",
        "output": "37"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.FC(F)(F)c1ccccc1CCN1CCNCC1.O.O=C(Cl)CBr>>O=C(CBr)N1CCN(CCc2ccccc2C(F)(F)F)CC1",
        "output": "125"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC(C)C(=O)N1CCCC1C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC(C)C(=O)N1CCCC1C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCC.CCOC(=O)c1cc(CCOC)n2cccc(C(F)(F)F)c12.NCC1CCC(F)(F)CC1>>COCCc1cc(C(=O)NCC2CCC(F)(F)CC2)c2c(C(F)(F)F)cccn12",
        "output": "498"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#Cc1cccc(Nc2ncnc3sc4c(c23)CNC4)c1.CN(C)C/C=C/C(=O)O.Cl>>C#Cc1cccc(Nc2ncnc3sc4c(c23)CN(C(=O)/C=C/CN(C)C)C4)c1",
        "output": "870"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCC.ClCCl.O=[Cr](=O)([O-])Cl.OCCCCc1ccc2ccc3cccc4ccc1c2c34.c1cc[nH+]cc1>>O=CCCCc1ccc2ccc3cccc4ccc1c2c34",
        "output": "142"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(O)CCNC1.CCN(C(C)C)C(C)C.Cl.ClCCl.O=S(=O)(Cl)c1ccc(Br)cc1>>CC1(O)CCN(S(=O)(=O)c2ccc(Br)cc2)C1",
        "output": "99"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "N#Cc1cc(I)cnc1O.O.O=P(Cl)(Cl)Cl.O=S(=O)(O)O>>N#Cc1cc(I)cnc1Cl",
        "output": "41"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc2onc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c2c1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1noc2ccc(CBr)cc12",
        "output": "29"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.COC(=O)c1cc([N+](=O)[O-])c(C#N)cc1C.[Fe]>>COC(=O)c1cc(N)c(C#N)cc1C",
        "output": "481"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Clc1ncc(Cl)c(Cl)n1.O=C(NC12CNCC1C2)C1CC1>>O=C(NC12CC1CN(c1nc(Cl)ncc1Cl)C2)C1CC1",
        "output": "296"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2CCC(OCCO)CC2)c2ncnn12.CCOC(C)=O.CI.CN(C)C=O.[H-].[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(C2CCC(OCCOC)CC2)c2ncnn12",
        "output": "140"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc(CN(CCCC#N)Cc2ccc(OC)cc2)cc1.ClCCl.O.O=S(=O)([O-])O.OO.[Na+].[OH-]>>COc1ccc(CN(CCCC(N)=O)Cc2ccc(OC)cc2)cc1",
        "output": "632"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC1(C)OB(c2ccc3c(c2)CCC3=O)OC1(C)C.Cc1cnc(Cl)nc1.O.O=C([O-])[O-].[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cnc(-c2ccc3c(c2)CCC3=O)nc1",
        "output": "974"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CNCCCS(=O)CCC(F)(F)F.Oc1ccc2c(c1)CCCC(c1ccccc1)=C2CCCCCCBr>>CN(CCCCCCC1=C(c2ccccc2)CCCc2cc(O)ccc21)CCCS(=O)CCC(F)(F)F",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)NCC1CCCCN1c1nc(Nc2ccc3cn[nH]c3c2)ncc1F.O=C(O)C(F)(F)F>>NCC1CCCCN1c1nc(Nc2ccc3cn[nH]c3c2)ncc1F",
        "output": "538"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)CCc1ccc(F)c(Br)c1>>O=C(Cl)CCc1ccc(F)c(Br)c1",
        "output": "56"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.CCOC(C)=O.COc1ccc(S(=O)(=O)c2sc(S(N)(=O)=O)cc2C)cc1.ClCCl.O>>Cc1cc(S(N)(=O)=O)sc1S(=O)(=O)c1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrBr.CC(=O)c1ccc(C)cc1.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)c1ccc(C)c(Br)c1",
        "output": "98"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.N#Cc1cc(F)c(Cl)cc1F.O.[H-].[N-]=[N+]=NC[C@@H](O)c1ccccc1.[Na+]>>N#Cc1cc(F)c(Cl)cc1O[C@H](CN=[N+]=[N-])c1ccccc1",
        "output": "485"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C1COCCN1.CC(C)C1=CC(C(C)C)=C(c2ccccc2)C(C(C)C)(P(C2CCCCC2)C2CCCCC2)C1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Nc1cc(Br)ccc1Cl.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]>>Nc1cc(N2CCOCC2)ccc1Cl",
        "output": "294"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC1(C)Cc2cc(B(O)O)ccc2O1.CCCc1nc(N(C)C)[nH]c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCN(CC)CC.CCOC(C)=O.ClCCl.[Cu+2].c1ccncc1>>CCCc1nc(N(C)C)n(-c2ccc3c(c2)CC(C)(C)O3)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "962"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=C(NCCCCc1ccc(OCC(O)CO)c2ccccc12)OCc1ccccc1.[Pd]>>NCCCCc1ccc(OCC(O)CO)c2ccccc12",
        "output": "574"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.N#Cc1cccc2[nH]ccc12.NO>>NC(=NO)c1cccc2[nH]ccc12",
        "output": "400"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1cccc(-c2c(Cc3ccccc3)cnc3c(C(F)(F)F)cccc23)c1.O=Cc1ccc(C=C2SC(=O)NC2=O)cc1>>O=C1NC(=O)/C(=C/c2ccc(CNc3cccc(-c4c(Cc5ccccc5)cnc5c(C(F)(F)F)cccc45)c3)cc2)S1",
        "output": "359"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)CCCBr.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].Oc1ccc(C23CC4CC(CC(C4)C2)C3)cc1.[K+].[K+]>>CCOC(=O)CCCOc1ccc(C23CC4CC(CC(C4)C2)C3)cc1",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=C(C)C(=O)O.O=C(O)c1ccc(OCCCCCCCCCCCO)cc1>>C=C(C)C(=O)OCCCCCCCCCCCOc1ccc(C(=O)O)cc1",
        "output": "174"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.Clc1cc(Nc2ncnc3ccc(OC4CCNCC4)cc23)ccc1OCc1cnccn1>>CC(=O)N1CCC(Oc2ccc3ncnc(Nc4ccc(OCc5cnccn5)c(Cl)c4)c3c2)CC1",
        "output": "369"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN.Cl.ClCCl.O=S(=O)(Cl)c1c(Cl)cccc1Cl>>CNS(=O)(=O)c1c(Cl)cccc1Cl",
        "output": "43"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccnc(C)c1CO.ClCCl.O=S(Cl)Cl>>Cc1ccnc(C)c1CCl",
        "output": "477"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCc1ccc(S(=O)(=O)c2ccc(F)cc2)cc1S(=O)(=O)Cl.NC1CCOCC1>>CCCc1ccc(S(=O)(=O)c2ccc(F)cc2)cc1S(=O)(=O)NC1CCOCC1",
        "output": "43"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)Cn1cc(Cc2ncc[nH]2)c2ccccc21.O.[Na+].[OH-]>>O=C(O)Cn1cc(Cc2ncc[nH]2)c2ccccc21",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN.COC(=O)C1=C(C)NC(COCCN2C(=O)c3ccccc3C2=O)=C(C(=O)OC)C1c1ccccc1Cl.O>>COC(=O)C1=C(C)NC(COCCN)=C(C(=O)OC)C1c1ccccc1Cl",
        "output": "242"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C(Cc1ccc(OCc2csc(-c3ccc(C(C)(C)C)cc3)n2)cc1C)OCC.[Li+].[OH-]>>CCOC(Cc1ccc(OCc2csc(-c3ccc(C(C)(C)C)cc3)n2)cc1C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CN(C2CC2)CCN1.CC(=O)c1ccc(Cl)nc1.CCOC(C)=O.CS(C)=O>>CC(=O)c1ccc(N2CCN(C3CC3)CC2)nc1",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)C(C)c1ccc(Br)c(Cl)c1.[Na+].[OH-]>>CC(C(=O)O)c1ccc(Br)c(Cl)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCO.CNCc1cnc2ccccc2n1.O=C([O-])[O-].O=[N+]([O-])c1ccc(OCCCI)cc1.[K+].[K+]>>CN(CCCOc1ccc([N+](=O)[O-])cc1)Cc1cnc2ccccc2n1",
        "output": "184"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CN1CCCC1=O.Fc1ccc(-c2nc3cc(Cl)ccc3o2)cc1.O>>Clc1ccc2oc(-c3ccc(N4CCCCC4)cc3)nc2c1",
        "output": "26"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(O)c1cccc2cccnc12.c1ccc2sc(CC3CCCCN3)cc2c1>>O=C(c1cccc2cccnc12)N1CCCCC1Cc1cc2ccccc2s1",
        "output": "256"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.Clc1ncc(OCc2ccccc2)c2ccccc12.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[C-]#N.[C-]#N.[Fe+2].[Pd].[Pd].[Zn+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>N#Cc1ncc(OCc2ccccc2)c2ccccc12",
        "output": "726"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCC.OCCCC#Cc1ccc2ccccc2c1.[Pd]>>OCCCCCc1ccc2ccccc2c1",
        "output": "717"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CC(Cl)Cl.CCN(CC)CC.O=S(=O)(c1ccc(OC(F)(F)F)cc1)N1CCC(=NOCC2CCCNC2)CC1>>CC(=O)N1CCCC(CON=C2CCN(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)CC2)C1",
        "output": "125"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1ncc(-c2nc(N3CCOCC3)c3sc(-c4ccnc(F)c4)cc3n2)cn1.OC1CCCNC1>>Nc1ncc(-c2nc(N3CCOCC3)c3sc(-c4ccnc(N5CCCC(O)C5)c4)cc3n2)cn1",
        "output": "756"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O=[N+]([O-])c1cccc(-c2cc[nH]n2)c1.[Pd]>>Nc1cccc(-c2cc[nH]n2)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCCC1=O.Clc1nnc(Cc2ccccc2)c2ccccc12.O.O=[N+]([O-])c1ccc(C2CCNCC2)cc1>>O=[N+]([O-])c1ccc(C2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)cc1",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(NCc1ccccn1)C1(CCCCBr)c2ccccc2-c2ccccc21.c1ccc2nc(N3CCNCC3)ccc2c1>>O=C(NCc1ccccn1)C1(CCCCN2CCN(c3ccc4ccccc4n3)CC2)c2ccccc2-c2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)OC(=O)Cl.CC1(N2CCC(N3C(=O)N[C@H]4CCCC[C@@H]43)CC2)CCNCC1.CCN(C(C)C)C(C)C.Cc1ccccc1.ClCCl.O=C([O-])O.[Na+]>>CC(C)OC(=O)N1CCC(C)(N2CCC(N3C(=O)N[C@H]4CCCC[C@@H]43)CC2)CC1",
        "output": "219"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cn(C(CC2CCCOC2)C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N.O=C(O)C(F)(F)F>>COc1cn(C(CC2CCCOC2)C(=O)Nc2ccc(C(=O)O)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N",
        "output": "752"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.CN.COC(=O)C(NC(=O)C(NC(=O)OC(C)(C)C)C(C)(C)C)C1CCCCC1>>CNC(=O)C(NC(=O)C(NC(=O)OC(C)(C)C)C(C)(C)C)C1CCCCC1",
        "output": "392"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)OC[C@@H](Cn2ccc(N)n2)O1.CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.COc1ccc(F)c(OC2=CC(=O)N([C@@H](CC(C)C)C(=O)O)C2)c1F.F[P-](F)(F)(F)(F)F>>COc1ccc(F)c(OC2=CC(=O)N([C@@H](CC(C)C)C(=O)Nc3ccn(C[C@@H]4COC(C)(C)O4)n3)C2)c1F",
        "output": "795"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.O.O=Cc1cncc(-c2nc(NCc3ccccc3)c3c(-c4ccccc4)ccn3n2)c1.[BH4-].[Na+]>>OCc1cncc(-c2nc(NCc3ccccc3)c3c(-c4ccccc4)ccn3n2)c1",
        "output": "476"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[N+](C)(C)C.NC1(C(=O)O)CCCCC1.O.O.O.O.O.[OH-]>>CC(C)(C)OC(=O)NC1(C(=O)O)CCCCC1",
        "output": "626"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOCC.O=C1Nc2ccccc2C=Cc2ccccc21.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>C1=Cc2ccccc2NCc2ccccc21",
        "output": "215"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)c1ccc(Cl)c(C(=O)Nc2cnc3[nH]ccc3c2)c1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)c1ccc(Cl)c(C(=O)Nc2cnc3[nH]ccc3c2)c1",
        "output": "752"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCP(=O)=O.CN1CCOCC1.Cc1ccn2ccnc(N3CC[C@H](N)C3)c12.ClCCl.O=C(O)c1ccn(-c2ccc(F)cc2)n1>>Cc1ccn2ccnc(N3CC[C@H](NC(=O)c4ccn(-c5ccc(F)cc5)n4)C3)c12",
        "output": "816"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1ccccc1.O=Cc1c(O)ccc2c1CCCO2.c1ccccc1>>Oc1ccc2c(c1CNc1ccccc1)CCCO2",
        "output": "359"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.C=O.CCN(CC)CC.CCOCC.Oc1ccccc1Br.[Cl-].[Cl-].[Mg+2]>>O=Cc1cccc(Br)c1O",
        "output": "451"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCN1.CCN(C(C)C)C(C)C.Cc1nn(CCO)c(C)c1CC(=O)NCc1cccc(Cl)c1C.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1nn(CCN2CCOCC2)c(C)c1CC(=O)NCc1cccc(Cl)c1C",
        "output": "371"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccc(C(=O)Cl)cc1.Nc1cc(C#Cc2cnc3ccc(-c4ccc(C(=O)N5CCOCC5)cc4)nn23)ccn1>>Cc1ccc(C(=O)Nc2cc(C#Cc3cnc4ccc(-c5ccc(C(=O)N6CCOCC6)cc5)nn34)ccn2)cc1",
        "output": "463"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(C)=O.Nc1cncc(-c2cccc(F)c2)n1.O.O=C1CCC(=O)N1Br>>Nc1cnc(Br)c(-c2cccc(F)c2)n1",
        "output": "665"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cnc(N2CCC(n3cc(F)c4c(Nc5ccc(C(=O)N(C)C)cc5F)ncnc43)CC2)nc1.Cl.O.[Na+].[OH-]>>CN(C)C(=O)c1ccc(Nc2ncnc3c2c(F)cn3C2CCN(c3ncc(C(=O)O)cn3)CC2)c(F)c1",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1cccc(N)c1.CC(C)(C)OC(=O)N1CCC(=O)CC1.CC(C)O.[BH3-]C#N.[Na+]>>CC(=O)Nc1cccc(NC2CCN(C(=O)OC(C)(C)C)CC2)c1",
        "output": "469"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.Cl.Cl.Cl.NCCc1ncc(Br)cc1Cl.O=C(O)c1ccccc1C(F)(F)F.On1nnc2ccccc21>>O=C(NCCc1ncc(Br)cc1Cl)c1ccccc1C(F)(F)F",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1.O=C(O)C(F)(F)F.O=CC1CC1.[BH3-]C#N.[Na+]>>FC(F)(F)c1cc(COCC2(c3ccccc3)CCCN(CC3CC3)CC2)cc(C(F)(F)F)c1",
        "output": "484"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C1O[C@@H](CO)CN1c1ccc(N2CC3CC4(CC3C2)OCCO4)c(F)c1>>CS(=O)(=O)OC[C@H]1CN(c2ccc(N3CC4CC5(CC4C3)OCCO5)c(F)c2)C(=O)O1",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)[C@@H]2CC[C@@]1(C)c1[nH]n(-c3ccc(F)cc3F)c(=O)c12.CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.COc1ccc(CBr)cc1.[I-]>>COc1ccc(Cn2c3c(c(=O)n2-c2ccc(F)cc2F)[C@H]2CC[C@]3(C)C2(C)C)cc1",
        "output": "635"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCCCC1.C1CCOC1.CCCBr.CC[N+](CC)(CC)Cc1ccccc1.O.OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F.[Cl-].[Na+].[OH-]>>CCCOCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F",
        "output": "95"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COc1cc(OC)c(F)c(N2Cc3cnc4c(cc(CN5CCOCC5)n4S(=O)(=O)c4ccccc4)c3C(C)(C)C2=O)c1F.[F-]>>COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(CN5CCOCC5)cc4c3C(C)(C)C2=O)c1F",
        "output": "831"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.Cl.ClC(Cl)Cl.NCC1CCOC1.O=C(O)c1cc(CCCOc2ccccc2)on1.On1nnc2ccccc21>>O=C(NCC1CCOC1)c1cc(CCCOc2ccccc2)on1",
        "output": "696"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.O=Cc1c(F)cc(O)cc1F.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.OCCF>>O=Cc1c(F)cc(OCCF)cc1F",
        "output": "478"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(O)CN.CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CC(=O)N2CCCC2)c1=O>>CC(O)CNC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CC(=O)N2CCCC2)c1=O",
        "output": "498"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.Cl.O=C(c1cc2ccccc2[nH]1)N1C[C@@H]2C[C@H]1CN2.[Na+]>>CN1C[C@@H]2C[C@H]1CN2C(=O)c1cc2ccccc2[nH]1",
        "output": "217"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNC1.CCN(CC)CC.Clc1nc(NCc2ccccc2)c2ccccc2n1>>c1ccc(CNc2nc(N3CCCC3)nc3ccccc23)cc1",
        "output": "36"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCCc1ccc(OC(=O)c2ccc3c(c2N)C(=O)c2ccc(C)c([N+](=O)[O-])c2C3=O)cc1.CCO.Cc1ccccc1.[H][H].[Pd]>>CCCCCCCc1ccc(OC(=O)c2ccc3c(c2N)C(=O)c2ccc(C)c(N)c2C3=O)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.CSc1nccc(C#Cc2c(-c3ccccc3)ncn2C)n1.O.O=S([O-])OO.[K+]>>Cn1cnc(-c2ccccc2)c1C#Cc1ccnc(S(C)(=O)=O)n1",
        "output": "840"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.C[C@H](CO)n1ccc2c([N+](=O)[O-])c(C3CC3)ccc2c1=O.ClCCl.c1ccncc1>>CC(=O)OC[C@@H](C)n1ccc2c([N+](=O)[O-])c(C3CC3)ccc2c1=O",
        "output": "254"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "NCCCC(F)(F)F.O=C(Cl)C(c1ccccc1)c1ccccc1>>O=C(NCCCC(F)(F)F)C(c1ccccc1)c1ccccc1",
        "output": "45"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.C1CCOC1.COC(=O)[C@H]1NCC[C@H]1c1ccc(C(F)(F)F)cc1>>OC[C@H]1NCC[C@H]1c1ccc(C(F)(F)F)cc1",
        "output": "430"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CN(C)C=O.C[C@H](N)C(F)(F)F.Cc1ccccc1.Cl.O=C(Cl)C(=O)Cl.O=C(O)c1cc(F)c(F)cc1F.[Na+].[OH-]>>C[C@H](NC(=O)c1cc(F)c(F)cc1F)C(F)(F)F",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)c1cccc(NS(=O)(=O)Nc2ccc3c(c2)S(=O)(=O)N=C(c2c(O)c4cccnc4n(CCC(C)C)c2=O)N3)c1.CO.[Na+].[OH-]>>CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(NS(=O)(=O)Nc4cccc(C(=O)O)c4)ccc3N2)c(O)c2cccnc21",
        "output": "5"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1ccc2nc(N[C@@H]3CCc4ccccc43)ccc2c1.O=S1(=O)CCN(S(=O)(=O)Cl)CC1>>O=S1(=O)CCN(S(=O)(=O)Nc2ccc3nc(N[C@@H]4CCc5ccccc54)ccc3c2)CC1",
        "output": "395"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(OCCOc2ccc(-c3ccc4c(c3)N(C(=O)Nc3nc5ccccc5s3)CCC4)nc2C(=O)O)c1.CS(C)=O>>Nc1cccc(OCCOc2ccc(-c3ccc4c(c3)N(C(=O)Nc3nc5ccccc5s3)CCC4)nc2C(=O)O)c1",
        "output": "782"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CC(=O)[O-].CC(=O)[O-].CCOC(=O)c1sc2c(ccc(=O)n2-c2ccc(Br)cc2)c1-c1ccccc1.Cc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2]>>CCOC(=O)c1sc2c(ccc(=O)n2-c2ccc(N3CCOCC3)cc2)c1-c1ccccc1",
        "output": "294"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)C(C)C.CCO.CCOCC.CC[O-].O=Cc1ccc(F)cc1.[Na+]>>CC(C)C(=O)C=Cc1ccc(F)cc1",
        "output": "295"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=C(O)Cc1ccc(O)cc1>>CCOC(=O)Cc1ccc(O)cc1",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCc1ccccc1.CCN(CC)CC.CN(C)C=O.O=C(O)c1ccc[nH]1>>O=C(OCc1ccccc1)c1ccc[nH]1",
        "output": "403"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNCC1.Cc1ccccc1.Clc1ccc(-c2nc3c(s2)CCN(C2CCC2)CC3)cn1>>c1cc(N2CCCCC2)ncc1-c1nc2c(s1)CCN(C1CCC1)CC2",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)N(Cc1cccc(Cl)c1)c1c([N+](=O)[O-])cc([N+](=O)[O-])cc1C(F)(F)F.CCOC(C)=O.[Pd]>>CCOC(=O)N(Cc1cccc(Cl)c1)c1c(N)cc(N)cc1C(F)(F)F",
        "output": "204"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(Cl)nc2c1.CS(C)=O.NC1CCCC1.O>>COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(NC3CCCC3)nc2c1",
        "output": "148"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)N1CCN(C(=O)OCc2ccccc2)CC1.CCO.[Pd]>>CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)N1CCNCC1",
        "output": "428"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1c[nH]cn1.Cc1cncn1-c1ccc(OC(F)(F)F)cc1C#N.N#Cc1cc(OC(F)(F)F)ccc1F.O=C([O-])[O-].[K+].[K+]>>Cc1cn(-c2ccc(OC(F)(F)F)cc2C#N)cn1",
        "output": "721"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Nn1nc(-c2ccc(Cl)cc2)c2ccccc2c1=O.O=C(O)Cc1ccc(O)cc1>>O=C(Cc1ccc(O)cc1)Nn1nc(-c2ccc(Cl)cc2)c2ccccc2c1=O",
        "output": "459"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN(C)CC(=O)Cl.Cl.Clc1ccc(N2CCNCC2)cn1>>CN(C)CC(=O)N1CCN(c2ccc(Cl)nc2)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOc1cc(CN2CCC(Nc3nc4cccc(C(=O)OC)c4o3)CC2)ccc1C.CO.Cl.O.[Li+].[OH-]>>CCOc1cc(CN2CCC(Nc3nc4cccc(C(=O)O)c4o3)CC2)ccc1C",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1cc(Br)cc(NS(C)(=O)=O)c1.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cc(NS(C)(=O)=O)cc(B2OC(C)(C)C(C)(C)O2)c1",
        "output": "942"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCCOc1ccc(CC(OC)OC)cc1[N+](=O)[O-].CCO.O=C[O-].O=Cc1ccc(O)c([N+](=O)[O-])c1.[NH4+].[Pd]>>CCCCCCCCOc1ccc(CC(OC)OC)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.COCCOC.Cl[Pd]Cl.NC(=O)c1cn(-c2ccc(F)cc2)c2ccc(Br)cc2c1=O.O.O=C([O-])[O-].OB(O)c1cccnc1.[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>NC(=O)c1cn(-c2ccc(F)cc2)c2ccc(-c3cccnc3)cc2c1=O",
        "output": "899"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOCC.Cl.O.O.O.O.O.O.O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].Oc1ccc(OCc2ccccc2)cc1.[La+3].[Na+]>>O=[N+]([O-])c1cc(OCc2ccccc2)ccc1O",
        "output": "103"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.[Pd].c1ccc(CN2CCc3nc4ccccc4c(-c4ccccc4)c3C2)cc1>>c1ccc(-c2c3c(nc4ccccc24)CCNC3)cc1",
        "output": "84"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br.Br.CC(C)(C)OC(=O)N[C@H](Cc1ccncc1)C(=O)O.CN1CCC(C2CCNCC2)CC1>>CN1CCC(C2CCN(C(=O)[C@@H](Cc3ccncc3)NC(=O)OC(C)(C)C)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2ccc(-c3c(F)cc4[nH]c(O[C@H]5COC6C5OC[C@@H]6O)nc4c3F)cc2)cc1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1ccc(-c2ccc(-c3c(F)cc4[nH]c(O[C@H]5COC6C5OC[C@@H]6O)nc4c3F)cc2)cc1",
        "output": "444"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)COc1cc(C)c(S(=O)(=O)c2c(OC)ccc3nc(SCc4ncc(C)c(OC)c4C)[nH]c23)c(C)c1.O=C(OO)c1cccc(Cl)c1>>COC(=O)COc1cc(C)c(S(=O)(=O)c2c(OC)ccc3nc(S(=O)Cc4ncc(C)c(OC)c4C)[nH]c23)c(C)c1",
        "output": "595"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)c1ccncc1.Cc1cc(C#N)cc(C)c1-c1csc(N)n1.Cl.ClCCl.O=C(Cl)c1ccncc1>>Cc1cc(C#N)cc(C)c1-c1csc(NC(=O)c2ccncc2)n1",
        "output": "673"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.O.O=C1C2CC3CC1CN(C3)C2.[BH4-].[Cl-].[Na+].[Na+]>>OC1C2CC3CC1CN(C3)C2",
        "output": "91"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNC1.CCn1cc(C(=O)O)c(=O)c2cc(Cl)c(Cl)cc21.CS(C)=O>>CCn1cc(C(=O)O)c(=O)c2cc(Cl)c(N3CCCC3)cc21",
        "output": "280"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)c1cc[nH+]cc1.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.O=C(O)CBr.OCC1c2ccccc2-c2ccccc21>>O=C(CBr)OCC1c2ccccc2-c2ccccc21",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCN(CCCC)C(=O)c1nn(-c2ccc(C(=O)O)cc2C(=O)OCC)c(C)c1Cl.CCCCN(CCCC)C(=O)c1nn(-c2ccc(C(=O)OCc3ccccc3)cc2C(=O)N2CCc3ccccc3C2)c(C)c1/C=C/C(=O)OC(C)(C)C>>CCCCN(CCCC)C(=O)c1nn(-c2ccc(C(=O)O)cc2C(=O)N2CCc3ccccc3C2)c(C)c1/C=C/C(=O)OC(C)(C)C",
        "output": "290"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(-c2ccc(S(N)(=O)=O)cc2)c(-c2ccc(F)cc2)s1.[Na+].[Na+].[OH-].[OH-]>>NS(=O)(=O)c1ccc(-c2cc(C(=O)O)sc2-c2ccc(F)cc2)cc1",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCOC(=O)c1ccn(C)c1C.Cl.O.[Li+].[OH-]>>Cc1c(C(=O)O)ccn1C",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CNCCO.CS(=O)(=O)c1cc(C#N)ccc1C1C2=C(CCC2=O)N(c2cccc(C(F)(F)F)c2)C(=O)N1CC(=O)O.F[B-](F)(F)F>>CN(CCO)C(=O)CN1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)C1c1ccc(C#N)cc1S(C)(=O)=O",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCC/C=C\\C/C=C\\CCCCCCCC(=O)O.CCN(CC)CC.CCOC(=O)Cl.ClCCl.NC1CCc2ccccc21>>CCCCC/C=C\\C/C=C\\CCCCCCCC(=O)NC1CCc2ccccc21",
        "output": "599"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1CN(Cc2ccccc2)CCC1=O.CCOCC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC1CN(Cc2ccccc2)CCC1O",
        "output": "91"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)N(CC(=O)O)S(=O)(=O)c1ccc(F)cc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.NCc1cc(N2CCC(C(F)(F)F)CC2)ncn1>>CC(C)N(CC(=O)NCc1cc(N2CCC(C(F)(F)F)CC2)ncn1)S(=O)(=O)c1ccc(F)cc1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1ccc(S(=O)(=O)O)cc1.O=C(O)Cc1ccc(Br)cc1>>CCOC(=O)Cc1ccc(Br)cc1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrP(Br)Br.COc1ccc(CCCO)cc1>>COc1ccc(CCCBr)cc1",
        "output": "301"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1[N+](=O)[O-].[Pd]>>COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1N",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)CC(C)c1ccc(-c2ccc(F)cc2F)cc1.[K+].[OH-]>>CC(CC(=O)O)c1ccc(-c2ccc(F)cc2F)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCCCCC.Nc1cccnc1SCCSc1ccccc1.O=C(Cl)Cc1cccs1.O=C([O-])O.[Na+]>>O=C(Cc1cccs1)Nc1cccnc1SCCSc1ccccc1",
        "output": "422"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.Cl.Nc1onc(-c2ccccc2OC(F)(F)F)c1C(=O)O.Oc1cccc2[nH]nnc12.Oc1ccccc1N1CCNCC1>>Nc1onc(-c2ccccc2OC(F)(F)F)c1C(=O)N1CCN(c2ccccc2O)CC1",
        "output": "975"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCOc1ccc(B(O)O)cc1.Fc1cccc(-c2nc3cnn(Cc4ccc(Cl)nc4)cc-3n2)c1F>>CCCOc1ccc(-c2ccc(Cn3cc4nc(-c5cccc(F)c5F)nc-4cn3)cn2)cc1",
        "output": "865"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC(=O)N(c2cccc(Cl)c2)C[C@@H]1CCO.CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)N1CC(=O)N(c2cccc(Cl)c2)C[C@@H]1CC=O",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(COc2ccc(-c3ccc(C)cc3)cc2)o1.CO.O.O.[Li+].[OH-]>>Cc1ccc(-c2ccc(OCc3ccc(C(=O)O)o3)cc2)cc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.N#C[C@@H]1C[C@H](F)CN1C(=O)CN(C(=O)OCc1ccccc1)C12CCC(C(=O)N3CCCCC3)(CC1)CC2.O=C[O-].[C].[NH4+].[Pd]>>N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)N3CCCCC3)(CC1)CC2",
        "output": "568"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.COC(=O)C1(N)CCCCC1.Cl.Cl.ClCCl.O=C(O)c1ccc(CCl)cc1.On1nnc2ccccc21>>COC(=O)C1(NC(=O)c2ccc(CCl)cc2)CCCCC1",
        "output": "652"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.Cc1ccc(F)c2c1C(=O)CCO2.[Zn]>>Cc1ccc(F)c2c1CCCO2",
        "output": "92"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1.O.O.[Li+].[OH-]>>O=C(O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.NCc1cccc2c1C1(CCN(Cc3ccccc3)C1)CN2>>CC(C)(C)OC(=O)NCc1cccc2c1C1(CCN(Cc3ccccc3)C1)CN2",
        "output": "686"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.Cc1ccc(O)c([N+](=O)[O-])c1.[Pd]>>Cc1ccc(O)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(=O)CC1.ClCCl.N[C@H]1CCCC[C@@H]1N.O=C([O-])O.[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCC(N[C@H]2CCCC[C@@H]2N)CC1",
        "output": "236"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.ClCc1ccc2ccccc2n1.OCc1ccc(O)cc1.[H-].[Na+]>>OCc1ccc(OCc2ccc3ccccc3n2)cc1",
        "output": "616"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCS.N#Cc1cccc(Cl)n1.[H-].[Na+]>>CCSc1cccc(C#N)n1",
        "output": "333"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCCC1=O.CS(=O)(=O)NC1CCC(N)CC1.Clc1nccc(-c2cnc3ccccn23)n1.O>>CS(=O)(=O)NC1CCC(Nc2nccc(-c3cnc4ccccn34)n2)CC1",
        "output": "544"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(Cl)CS[C@H]12)c1ncsn1.CC(C)OC(C)C.CCCCCC.COc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(Cl)CS[C@H]12)c1ncsn1",
        "output": "278"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.C=CCC1(O)CCN(C(C)=O)CC1.Cc1cccc(C)n1.O.O=[Os](=O)(=O)=O.[Na+].[O-][I+3]([O-])([O-])[O-]>>CC(=O)N1CCC(O)(CC=O)CC1",
        "output": "571"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.Nc1ncnc2c1c(-c1ccccc1)cn2-c1cccc(OCc2ccccc2)c1.[H][H].[Pd]>>Nc1ncnc2c1c(-c1ccccc1)cn2-c1cccc(O)c1",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)c1c(OCc2ccccc2)cnc(OC(C)C)c1C.[Pd]>>COC(=O)c1c(O)cnc(OC(C)C)c1C",
        "output": "264"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.C[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.N#Cc1c(SCc2csc(-c3ccc(Cl)cc3)n2)nc(N2CCCC2)c(C#N)c1-c1ccc(OCCO)cc1.O.On1nnc2ccccc21>>C[C@H](NC(=O)OC(C)(C)C)C(=O)OCCOc1ccc(-c2c(C#N)c(SCc3csc(-c4ccc(Cl)cc4)n3)nc(N3CCCC3)c2C#N)cc1",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CO.Cc1cc(-c2ccnc(N[C@@H](C)c3ccccc3)c2)nc(N2CC3CC2CN3C(=O)OC(C)(C)C)n1.Cl.ClCCl>>Cc1cc(-c2ccnc(N[C@@H](C)c3ccccc3)c2)nc(N2CC3CC2CN3)n1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNCC1.COC1=C(OC)C(=O)C(Cc2cccc(CCCC(=O)O)c2)=C(C)C1=O>>COC1=C(OC)C(=O)C(Cc2cccc(CCCC(=O)N3CCCCC3)c2)=C(C)C1=O",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.O=[N+]([O-])c1ccc2ccc([N+](=O)[O-])cc2c1.[Pd]>>Nc1ccc2ccc(N)cc2c1",
        "output": "204"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCCO.O.O=C(O)c1ccc(B(O)O)cc1.O=C(O)c1ccc2cc(Br)ccc2c1.O=C([O-])[O-].[Na+].[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(O)c1ccc(-c2ccc3cc(C(=O)O)ccc3c2)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCCc1c[nH]c2ccccc12.CC#N.CCCC[N+](CCCC)(CCCC)CCCC.COc1cccnc1N1CCNCC1.O=C([O-])[O-].O=S(=O)([O-])O.[K+].[K+]>>COc1cccnc1N1CCN(CCc2c[nH]c3ccccc23)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCS(=O)(=O)c1ccc(Oc2cc(O)cc(CC(=O)OC)c2)c(Cl)c1.CN(C)C=O.CN(C)CCCl.Cl.O.O=C([O-])[O-].[K+].[K+]>>CCS(=O)(=O)c1ccc(Oc2cc(CC(=O)OC)cc(OCCN(C)C)c2)c(Cl)c1",
        "output": "74"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCC[C@@H](CNC(=O)C[C@H](CCCN)NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C.CC(C)(C)OC(=O)NCCC[C@H](NC(=O)OCc1ccccc1)C(=O)O.CN(C)C=O.ClCCCl.On1nnc2ccccc21>>CC(C)(C)OC(=O)NCCC[C@H](NC(=O)OCc1ccccc1)C(=O)NCCC[C@@H](CC(=O)NC[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#CC1(O)CCCC1.CC(=O)N1CC(c2c(C(N)=O)nc3n2C2CC(C2)c2ccc(Br)cc2-3)C1>>CC(=O)N1CC(c2c(C(N)=O)nc3n2C2CC(C2)c2ccc(C#CC4(O)CCCC4)cc2-3)C1",
        "output": "659"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=Cc1ccc(Br)cc1.CC(=O)N1CCNCC1.CC(=O)[O-].CC(=O)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2]>>C=Cc1ccc(N2CCN(C(C)=O)CC2)cc1",
        "output": "294"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.CC(C)[Si](Oc1ccc(Br)cc1)(C(C)C)C(C)C.[Li]CCCC>>CC(C)[Si](Oc1ccc(B(O)O)cc1)(C(C)C)C(C)C",
        "output": "832"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.CON=C(C(=O)O)c1csc(N)n1.ClCCl.ClP(Cl)(Cl)(Cl)Cl.Cn1nnnc1SCC1=C(C(=O)O)N2C(=O)C(N)[C@H]2SC1.O=C([O-])O.O=C([O-])[O-].[Na+].[Na+].[Na+]>>CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CSc3nnnn3C)CS[C@H]12)c1csc(N)n1",
        "output": "587"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)C1(C(=O)O)CCN(C(=O)OC(C)(C)C)CC1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.[NH4+].[OH-]>>CC(C)C1(C(N)=O)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "313"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Clc1nccc(N2CCC3(CC2)OCCO3)n1.NCc1ccccc1.O>>c1ccc(CNc2nccc(N3CCC4(CC3)OCCO4)n2)cc1",
        "output": "364"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCOC(=O)Cl.Cc1cc(Br)cc(C)c1N.O>>CCOC(=O)Nc1c(C)cc(Br)cc1C",
        "output": "102"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.NCCc1ccc(N)cc1.O=S(=O)(Cl)c1ccc(Cl)cc1>>Nc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)O.Cc1cc(CO[Si](C)(C)C(C)(C)C)cc(C)c1OC(=O)C(C)NC(=O)OC(C)(C)C.O>>Cc1cc(CO)cc(C)c1OC(=O)C(C)NC(=O)OC(C)(C)C",
        "output": "708"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCCOCCOc1ccc(-c2ccc(N3CCC(CC(=O)OCC)C3)c(/C=C(\\C)C(=O)Nc3ccc([S@@](=O)Cc4cncn4CCC)cc3)c2)cc1.CO.Cl.O.O.[Cl-].[Na+].[Na+].[OH-]>>CCCCOCCOc1ccc(-c2ccc(N3CCC(CC(=O)O)C3)c(/C=C(\\C)C(=O)Nc3ccc([S@@](=O)Cc4cncn4CCC)cc3)c2)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCN1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)c1ccncc1.F[P-](F)(F)(F)(F)F.NC(=O)c1cc(Br)cc2c1[nH]c1ccc(C(=O)O)cc12.O>>NC(=O)c1cc(Br)cc2c1[nH]c1ccc(C(=O)N3CCOCC3)cc12",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCc1c(O)ccc(C(C)=O)c1O.CN(C)C=O.COC(=O)CCCCCCCCCCBr.O=C([O-])[O-].[K+].[K+]>>CCCc1c(OCCCCCCCCCCC(=O)OC)ccc(C(C)=O)c1O",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(CC(=O)O)cc1OC.CO.Cl.O=C([O-])O.[Na+]>>CCCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(CC(=O)OC)cc1OC",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1cnc(Br)s1.CN(C)C=O.O.O=C([O-])[O-].OCCC1(N2CCCC2)CCNCC1.[K+].[K+]>>OCCC1(N2CCCC2)CCN(c2ncc(Br)s2)CC1",
        "output": "657"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)C1CCN(c2cnc(N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)Cc3cc4ccccc4c(=O)[nH]3)nc2)CC1.Cl.O.[Na+].[OH-]>>O=C(O)C1CCN(c2cnc(N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)Cc3cc4ccccc4c(=O)[nH]3)nc2)CC1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.COC(=O)CC(C(=O)OC)c1cc(C=O)c(O)c(-c2cccc([N+](=O)[O-])c2)c1.COCCOCCl.ClCCl.O>>COCCOCOc1c(C=O)cc(C(CC(=O)OC)C(=O)OC)cc1-c1cccc([N+](=O)[O-])c1",
        "output": "375"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCCCCCCCCC(=O)O.Cc1ccccc1.O=S(Cl)Cl>>CCCCCCCCCCCCCCC(=O)Cl",
        "output": "53"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CCCNC1.CC(C)O.CCN(CC)CC.O=[N+]([O-])c1cnc2c(c1Cl)CCC2>>CC(C)(C)OC(=O)N[C@H]1CCCN(c2c([N+](=O)[O-])cnc3c2CCC3)C1",
        "output": "398"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CN.O=C(O)c1ccc2c(c1)OCCn1cc(-c3ncnn3CC(F)(F)F)nc1-2>>CNC(=O)c1ccc2c(c1)OCCn1cc(-c3ncnn3CC(F)(F)F)nc1-2",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCOC(C)=O.CN1CCCN(c2cncc(Cl)n2)CC1.O.O=C([O-])[O-].O=Cc1cccc(B(O)O)c1.[Cs+].[Cs+]>>CN1CCCN(c2cncc(-c3cccc(C=O)c3)n2)CC1",
        "output": "875"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[O-].CC1CCC(CBr)CC1.CCCCO.[K+].c1c[nH]cn1>>CC1CCC(Cn2ccnc2)CC1",
        "output": "276"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C(=O)O)c1ccc(S(=O)(=O)/C=C/C#N)cc1.CCN=C=NCCCN(C)C.C[C@H](N)c1ccccc1.Cl.ClCCl.On1nnc2ccccc21>>C[C@H](NC(=O)C(C)(C)c1ccc(S(=O)(=O)/C=C/C#N)cc1)c1ccccc1",
        "output": "599"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CNC3)cc1.CCOC(=O)Cl>>CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CN(C(=O)OCC)C3)cc1",
        "output": "219"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.COc1ccc(Cn2nc(CO)cc(OCc3ccccc3)c2=O)cc1.ClCCl.c1c[nH]cn1>>COc1ccc(Cn2nc(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)cc(OCc3ccccc3)c2=O)cc1",
        "output": "602"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1c(-c2cccc(C(=O)O)c2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12.NCC(O)CO>>Cc1c(-c2cccc(C(=O)NCC(O)CO)c2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(OC2CCN(C)CC2)c2c(Nc3ccc4[nH]ccc4c3)ncnc2c1.ClCc1ccccc1>>COc1cc(OC2CCN(C)CC2)c2c(Nc3ccc4c(ccn4Cc4ccccc4)c3)ncnc2c1",
        "output": "556"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COC(=O)c1cc2cc(CBr)ccc2s1.O.Oc1cccnc1.[H-].[Na+]>>COC(=O)c1cc2cc(COc3cccnc3)ccc2s1",
        "output": "623"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CI.CN(C)C=O.Cc1c(C(=O)OC(C)(C)C)oc2cccc(O)c12.O=C([O-])[O-].[K+].[K+]>>COc1cccc2oc(C(=O)OC(C)(C)C)c(C)c12",
        "output": "62"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)NCCN.COc1ccc(C(=O)O)c2nc(-c3cccs3)[nH]c12>>COc1ccc(C(=O)NCCNC(C)=O)c2nc(-c3cccs3)[nH]c12",
        "output": "674"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.CC(=O)O.NC(=O)c1cc(-c2cccnc2[C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc3c(c2C(F)(F)F)CNC3)ccc1F.[BH3-]C#N.[Na+]>>CN1Cc2nn(CC(=O)N[C@@H](Cc3cc(F)cc(F)c3)c3ncccc3-c3ccc(F)c(C(N)=O)c3)c(C(F)(F)F)c2C1",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.O=[N+]([O-])O.Oc1cc2ccccc2cc1O>>O=[N+]([O-])c1cccc2cc(O)c(O)cc12",
        "output": "21"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)CN.ClC(Cl)Cl.ClCCCl.O=Cc1ccc2c(c1)OCCCO2.[Na+]>>CC(C)CNCc1ccc2c(c1)OCCCO2",
        "output": "468"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC1(C)OB(c2ccc(N)cc2)OC1(C)C.ClCCl.Nc1ncnc2ccc(Br)cc12.O=C([O-])[O-].[Fe+2].[Na+].[Na+].[Pd+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Nc1ccc(-c2ccc3ncnc(N)c3c2)cc1",
        "output": "933"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOc1cc([N+](=O)[O-])ccc1C(=O)OC.CO.[H][H].[Pd]>>CCOc1cc(N)ccc1C(=O)OC",
        "output": "772"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(N)C(Oc4ccccc4)C3)C(C)CCC1=O)C(C)CC2OC.CCN(CC)CC.ClCCl.O=C(Cl)C1CC1>>CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(NC(=O)C4CC4)C(Oc4ccccc4)C3)C(C)CCC1=O)C(C)CC2OC",
        "output": "45"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[O-].CO.COC(=O)C1CC(c2ccc(CC(F)(F)F)cc2)CN(C(C)=O)C1.[K+]>>CC(=O)N1CC(C(=O)O)CC(c2ccc(CC(F)(F)F)cc2)C1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)O.NC(=O)C1CCNCC1.O=Cc1ccc(C(=O)CNCCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)cc1.O=S(=O)([O-])[O-].[Na+].[Na+].[Na+]>>NC(=O)C1CCN(Cc2ccc(C(=O)CNCCN3CCC(OC(=O)Nc4ccccc4-c4ccccc4)CC3)cc2)CC1",
        "output": "567"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.O=[N+]([O-])c1cc(C(F)(F)F)ccc1-n1cccn1>>Nc1cc(C(F)(F)F)ccc1-n1cccn1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Nc1ccc(CCO)cc1.O.O=C1CCC(=O)N1Br>>Nc1ccc(CCO)cc1Br",
        "output": "4"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Oc1ccc2c(c1)C(=O)C(Br)=C2c1ccccc1.CC(=O)Oc1ccc2c(c1)C(=O)C(Br)=C2c1ccccc1F>>O=C1C(Br)=C(c2ccccc2F)c2ccc(O)cc21",
        "output": "22"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CN1CCCC1CCN.N#Cc1c(Cl)ncc2c1-c1ccccc1C(c1ccc(Cl)c(Cl)c1)C2>>CN1CCCC1CCNc1ncc2c(c1C#N)-c1ccccc1C(c1ccc(Cl)c(Cl)c1)C2",
        "output": "70"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)CC(F)(F)F.NN.O>>NNC(=O)CC(F)(F)F",
        "output": "130"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)c1nn(C)c2ccc([N+](=O)[O-])cc12.CO.[Pd]>>CN(C)c1nn(C)c2ccc(N)cc12",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C.CCO.O.O=[N+]([O-])c1ccc(N2CCOCC2)cn1.[OH-].[OH-].[Pd+2]>>Nc1ccc(N2CCOCC2)cn1",
        "output": "457"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)OC(C)C.CCN(C(C)C)C(C)C.CN(C)C(=O)CCC(=O)c1ccc(F)cc1.CO.ClCCl.ClCCl.N.c1ccc(CN2CCNCC2)cc1>>CN(C)C(=O)CCC(=O)c1ccc(N2CCN(Cc3ccccc3)CC2)cc1",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)O)cc1Cl.CSCc1cnc(N)cn1.ClCCl.O=C(Cl)C(=O)Cl.c1ccncc1>>CSCc1cnc(NC(=O)[C@H](CC2CCCC2)c2ccc(S(C)(=O)=O)c(Cl)c2)cn1",
        "output": "692"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCCCl.CN(C)C=O.Cc1cc(O)cc(C)c1-c1cccc(C=O)c1.O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CCOCCOc1cc(C)c(-c2cccc(C=O)c2)c(C)c1",
        "output": "74"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1=CCCCC1.CCO.CCOC(=O)C(C)(CCn1ccc(OCc2ccccc2)cc1=O)S(C)(=O)=O.[OH-].[OH-].[Pd+2]>>CCOC(=O)C(C)(CCn1ccc(O)cc1=O)S(C)(=O)=O",
        "output": "23"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1cccc2cccc(C)c12.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>Cc1cccc2cccc(CBr)c12",
        "output": "29"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)[C@@H]1CCCCN1C(=O)c1cc2ccccc2cc1N.Cc1cc(C)c(N=C=O)c(C)c1.c1ccncc1>>COC(=O)[C@@H]1CCCCN1C(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C",
        "output": "993"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.COc1ccc(C(CC2CCCC2)C(=O)Nc2nccs2)cc1F.ClCCl>>O=C(Nc1nccs1)C(CC1CCCC1)c1ccc(O)c(F)c1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(c1cc(Br)cc(C(=O)OC)c1C)C1CCCC1.CCO.CS(C)=O.Cc1cc(C)c(CN)c(=O)[nH]1.F[P-](F)(F)(F)(F)F.[Na+].[OH-].c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CCN(c1cc(Br)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCCC1",
        "output": "338"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)OCC1(CO[Si](C)(C)C(C)(C)C)Oc2ccc([N+](=O)[O-])cc2-n2nnnc21.CCO.[OH-].[OH-].[Pd+2]>>CC(C)(C)[Si](C)(C)OCC1(CO[Si](C)(C)C(C)(C)C)Oc2ccc(N)cc2-n2nnnc21",
        "output": "202"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.O=C(Cl)Oc1ccccc1.OCCSc1cccc2nccn12.c1ccncc1>>O=C(OCCSc1cccc2nccn12)Oc1ccccc1",
        "output": "144"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CCc1ccccc1OCC1CO1.CC1CC(=O)NN=C1c1ccc2nc(CCN)[nH]c2c1>>C=CCc1ccccc1OCC(O)CNCCc1nc2ccc(C3=NNC(=O)CC3C)cc2[nH]1",
        "output": "16"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=Cc1ccc(O)cc1.CCCCCCCCON1C(C)(C)CC(OCC2CO2)CC1(C)C>>C=Cc1ccc(OCC(O)COC2CC(C)(C)N(OCCCCCCCC)C(C)(C)C2)cc1",
        "output": "277"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.Cc1ccc(-c2[nH]ncc2Br)c(Cl)c1.[H-].[Na+]>>Cc1ccc(-c2c(Br)cnn2C)c(Cl)c1",
        "output": "229"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.NN.O=[N+]([O-])c1ccn(CCc2ccccc2)n1.[Ni]>>Nc1ccn(CCc2ccccc2)n1",
        "output": "684"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.COc1cc2[nH]ccc2cc1OCc1ccccc1.O=S(=O)(Cl)c1ccccc1.O=S(=O)([O-])O.[Na+].[OH-]>>COc1cc2c(ccn2S(=O)(=O)c2ccccc2)cc1OCc1ccccc1",
        "output": "648"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.FC(F)(F)c1cc(CO[C@H]2CCNC[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1>>CC(=O)N1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCC(=O)c1cc([N+](=O)[O-])ccc1O.CN(C)C=O.COC(=O)CBr.O.[H-].[Na+]>>CCC(=O)c1cc([N+](=O)[O-])ccc1OCC(=O)OC",
        "output": "557"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CNCCN1.O=S1CCN(c2nc(Cl)nc3nc(NCc4ccccc4)c(Cl)nc23)CC1>>O=S1CCN(c2nc(N3CCNCC3)nc3nc(NCc4ccccc4)c(Cl)nc23)CC1",
        "output": "36"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.N#Cc1ccc(F)cc1Cl.NC1CCCC(n2cncn2)C1>>N#Cc1ccc(NC2CCCC(n3cncn3)C2)cc1Cl",
        "output": "572"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.N#Cc1cccc(F)c1F.NN.O>>Nc1n[nH]c2c(F)cccc12",
        "output": "945"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C(O)Cn1nnnc1-c1ccccc1.O=S(=O)(O)O.OCCO>>O=C(Cn1nnnc1-c1ccccc1)OCCO",
        "output": "47"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccnc(N)c1.O=C(Cl)CCl>>Cc1ccnc(NC(=O)CCl)c1",
        "output": "332"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Nc1cc(-n2cc(-c3ncn(COCC[Si](C)(C)C)n3)c(-c3ccccc3Cl)n2)ccn1.CCOC(C)=O.CN(C)C=O.O=C1CCC(=O)N1Br>>CC(=O)Nc1cc(-n2cc(-c3ncn(COCC[Si](C)(C)C)n3)c(-c3ccccc3Cl)n2)c(Br)cn1",
        "output": "518"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C1Cc2ccc(C(=O)O)cc2N1.c1ccc2c(c1)C[C@@H]1NCCC[C@H]21>>O=C1Cc2ccc(C(=O)N3CCC[C@@H]4c5ccccc5C[C@@H]43)cc2N1",
        "output": "44"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(C)=O.CNC(=O)c1ccccc1Nc1nc(Nc2cc([N+](=O)[O-])cc3c2CCC3)ncc1Cl.O=[Pt]=O>>CNC(=O)c1ccccc1Nc1nc(Nc2cc(N)cc3c2CCC3)ncc1Cl",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccccc1.Nc1ccccc1.O=Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1.[BH4-].[Na+]>>FC(F)(F)c1cc(CNc2ccccc2)cc(C(F)(F)F)c1",
        "output": "359"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.Cc1ccc(Sc2ccccc2[N+](=O)[O-])c(C)c1.[Fe]>>Cc1ccc(Sc2ccccc2N)c(C)c1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)C1CCc2[nH]c3ccccc3c2C1.[NH4+].[OH-]>>NC(=O)C1CCc2[nH]c3ccccc3c2C1",
        "output": "313"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.C1COCCO1.CS(=O)(=O)Nc1ccc(B(O)O)cc1.Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)ncc1Br.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)ncc1-c1ccc(NS(C)(=O)=O)cc1",
        "output": "833"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)NCC(=O)c1ccc(O)c(O)c1.CC1(C)CC(C(=O)Cl)C1.Cl.[Cl-]>>CC(C)NCC(=O)c1ccc(OC(=O)C2CC(C)(C)C2)c(O)c1",
        "output": "111"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)C(=O)Cl.N#Cc1ccc(NCCCCO)c([N+](=O)[O-])c1.c1ccncc1>>CC(C)(C)C(=O)OCCCCNc1ccc(C#N)cc1[N+](=O)[O-]",
        "output": "126"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(Cc2cccc(-c3cccc(CN)c3)c2)CC1.CCN(CC)CC.CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cncc(C(=O)O)c1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cncc(C(=O)NCc2cccc(-c3cccc(CC4CCN(C(=O)OC(C)(C)C)CC4)c3)c2)c1",
        "output": "790"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)n1ncc2cc3c(cc21)CCCC1(C3)OCCO1.O.O=C(O)CCCc1ccc2cnn(-c3ccc(F)cc3)c2c1.[Li+].[OH-]>>CC(=O)n1ncc2cc3c(cc21)CCCC(=O)C3",
        "output": "251"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.NC1CCN(Cc2ccccc2)CC1>>CC(C)(C)OC(=O)NC1CCN(Cc2ccccc2)CC1",
        "output": "631"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1nccs1.O=C(O)C(CC1CCCC1)c1cccnc1>>O=C(Nc1nccs1)C(CC1CCCC1)c1cccnc1",
        "output": "681"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)c1ccc2[nH]c(-c3cc(C)cc(C)c3)c(CCNCCCCc3ccncc3)c2c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1cc(C)cc(-c2[nH]c3ccc(C(C)O)cc3c2CCNCCCCc2ccncc2)c1",
        "output": "24"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCCCCN=C=O.CCN(CC)CC.Oc1ccc2c(c1)N(Cc1ccccc1)CCC2>>CCCCCCNC(=O)Oc1ccc2c(c1)N(Cc1ccccc1)CCC2",
        "output": "104"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Nc1ccc(C[C@H](N)C(=O)O)cc1.O=C([O-])O.[Na+]>>CCOC(=O)[C@@H](N)Cc1ccc(N)cc1",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)COCc1cccnc1.NCC(O)CN1CCc2ccccc2C1>>O=C(COCc1cccnc1)NCC(O)CN1CCc2ccccc2C1",
        "output": "64"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc2c(c1)C(CCN)C(C)(C)CC2.Cl.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>COc1ccc2c(c1)C(CCNC(=O)C(F)(F)F)C(C)(C)CC2",
        "output": "316"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CS(=O)(=O)Cl.Nc1cc(Br)cc2[nH]ccc12>>CS(=O)(=O)Nc1cc(Br)cc2[nH]ccc12",
        "output": "194"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)N=C=NC(C)C.CN(C)C=O.C[C@H](N)c1ccccc1.Cn1nc(-c2ccccc2F)c2c(C(F)(F)F)cc(OCC(=O)O)nc21.On1nnc2ccccc21>>C[C@H](NC(=O)COc1cc(C(F)(F)F)c2c(-c3ccccc3F)nn(C)c2n1)c1ccccc1",
        "output": "599"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.Cc1cscc1C1CCCCC1.O=P(Cl)(Cl)Cl>>Cc1c(C2CCCCC2)csc1C=O",
        "output": "617"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(=O)OCCN1CCN(C)c2cc(Nc3ncc(Cl)c(N[C@@H]4CCCC[C@H]4NS(C)(=O)=O)n3)ccc2C1.CO.ClCCl.N.[Li+].[OH-]>>CN1CCN(CCO)Cc2ccc(Nc3ncc(Cl)c(N[C@@H]4CCCC[C@H]4NS(C)(=O)=O)n3)cc21",
        "output": "225"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#Cc1cnc2ccc(OC(SC)C(=O)NC(C)(CO)C(O[SiH2]C(C)(C)C)(c3ccccc3)c3ccccc3)cc2c1.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl>>C#Cc1cnc2ccc(OC(SC)C(=O)NC(C)(C=O)C(O[SiH2]C(C)(C)C)(c3ccccc3)c3ccccc3)cc2c1",
        "output": "142"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1nc(Oc2ccccc2)c(Cl)c(N)c1Cl.Cl.O.[Na+].[OH-]>>Nc1c(Cl)c(Oc2ccccc2)nc(C(=O)O)c1Cl",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.ClCCl.N#Cc1cc(Cl)ccc1N1CCOc2cc(S(=O)(=O)Cl)ccc21.Oc1c(F)c(F)c(F)c(F)c1F>>N#Cc1cc(Cl)ccc1N1CCOc2cc(S(=O)(=O)Oc3c(F)c(F)c(F)c(F)c3F)ccc21",
        "output": "380"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.ClCCCl.ClCCl.O=C(O)c1ccc(-c2ccccc2F)c2c3c([nH]c12)CCC(O)C3.On1nnc2cccnc21.[Cl-].[NH4+]>>NC(=O)c1ccc(-c2ccccc2F)c2c3c([nH]c12)CCC(O)C3",
        "output": "704"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Nc1ccc(Br)c(F)c1.CCO.Cl>>Nc1ccc(Br)c(F)c1",
        "output": "66"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc([N+](=O)[O-])ccc1OC1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>COc1cc([N+](=O)[O-])ccc1OC1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)c1cccc(C(C)C)c1N=C=O.Cc1ccc(S(=O)(=O)C2(CN)CCCC2)cc1>>Cc1ccc(S(=O)(=O)C2(CNC(=O)Nc3c(C(C)C)cccc3C(C)C)CCCC2)cc1",
        "output": "35"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCn1c(=O)c(NC(=O)Nc2c(C(C)C)cccc2C(C)C)c(-c2cccc(O)c2)c2cccnc21.CN(C)C=O.ClCCCBr.O.O=C([O-])[O-].[K+].[K+]>>CCCCn1c(=O)c(NC(=O)Nc2c(C(C)C)cccc2C(C)C)c(-c2cccc(OCCCCl)c2)c2cccnc21",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)c1ccc([C@H]2C[C@H](NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)C[C@@H](c3ccccc3)O2)c(C)c1.[Li+].[OH-]>>Cc1cc(C(=O)O)ccc1[C@H]1C[C@H](NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)C[C@@H](c2ccccc2)O1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1=COCCC1.CCOC(C)=O.COC(=O)c1cccc(-c2nc(C)sc2CO)c1.Cc1ccc(S(=O)(=O)O)cc1.O>>COC(=O)c1cccc(-c2nc(C)sc2COC2CCCCO2)c1",
        "output": "306"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=C1CC[C@H]2[C@H](CN)[C@@H]([C@@]3(C)CC[C@H](O)C[C@@H]3CO)CC[C@]12C.CCN=C=O>>C=C1CC[C@H]2[C@H](CNC(=O)NCC)[C@@H]([C@@]3(C)CC[C@H](O)C[C@@H]3CO)CC[C@]12C",
        "output": "244"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[C@@H]1CC[C@H](N)CC1.CCN(CC)CC.Cc1ccccc1.Clc1cc(Cl)ncn1>>CC(C)(C)[C@@H]1CC[C@H](Nc2cc(Cl)ncn2)CC1",
        "output": "166"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cc(-c2nc3c(CC(C)C)nc(Oc4ccccc4F)nc3o2)cc(C)c1OCC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>Cc1cc(-c2nc3c(CC(C)C)nc(Oc4ccccc4F)nc3o2)cc(C)c1OCC(=O)O",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C=O.O.O=[N+]([O-])c1ccc(/C=C/C2CC[NH2+]CC2)cc1.O=[N+]([O-])c1ccc(CCBr)cc1.[Cl-]>>O=[N+]([O-])c1ccc(/C=C/C2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)cc1",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.CNC.CO.ClCc1cc(Cl)c(-c2nc3c([nH]2)-c2ccncc2Nc2ncccc2-3)c(Cl)c1.[H-].[Na+]>>CN(C)Cc1cc(Cl)c(-c2nc3c([nH]2)-c2ccncc2Nc2ncccc2-3)c(Cl)c1",
        "output": "156"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)C(=O)c1ccc(S(=O)(=O)CCOc2ccc3ccccc3c2)cc1.O.[Na+].[OH-]>>O=C(O)C(=O)c1ccc(S(=O)(=O)CCOc2ccc3ccccc3c2)cc1",
        "output": "506"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2oc3ccc(OC4CCSCC4)cc3c2C)C2CCCCC2)cc1.[Na+].[OH-]>>Cc1c(C(Nc2ccc(C(=O)N(C)CCC(=O)O)cc2)C2CCCCC2)oc2ccc(OC3CCSCC3)cc12",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCC(Oc2ccc3cnc(Cl)cc3c2)CC1.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1CCC(Oc2ccc3cnc(Cl)cc3c2Br)CC1",
        "output": "4"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "B.C1CCOC1.C1CCOC1.Cc1cc(Br)ccc1C(=O)O>>Cc1cc(Br)ccc1CO",
        "output": "72"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "N#Cc1cccc(N)c1.O=C(O)C1CCc2c(sc3ncnc(Nc4ccc5[nH]ncc5c4)c23)C1>>N#Cc1cccc(NC(=O)C2CCc3c(sc4ncnc(Nc5ccc6[nH]ncc6c5)c34)C2)c1",
        "output": "365"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCC(=O)Cl.COc1ccc(N2CCOCC2)c2sc(N)nc12>>CCCCC(=O)Nc1nc2c(OC)ccc(N3CCOCC3)c2s1",
        "output": "553"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1cn(C)c(=O)c(Nc2ccc(CCOS(C)(=O)=O)cc2)n1.NC1CCOCC1.O>>Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1cn(C)c(=O)c(Nc2ccc(CCNC3CCOCC3)cc2)n1",
        "output": "559"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.O=Cc1cccc(-c2ccccc2)c1.[BH4-].[Cl-].[NH4+].[Na+]>>OCc1cccc(-c2ccccc2)c1",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.CC(C)(C)OC(=O)NC1CNCC12CCC2.CCN(C(C)C)C(C)C.ClCCCl.N#CC1(C(=O)O)CC1.On1nnc2ccccc21>>CC(C)(C)OC(=O)NC1CN(C(=O)C2(C#N)CC2)CC12CCC2",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.COC(=O)[C@H](CCN(C(=O)OC(C)(C)C)c1ncc(C=O)s1)NC(=O)OC(C)(C)C.C[Sn](C)(C)O.ClCCCl>>CC(C)(C)OC(=O)N[C@@H](CCN(C(=O)OC(C)(C)C)c1ncc(C=O)s1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCc1cc(-c2ccc(CN3CCCCC3)cc2)no1.Fc1cccc(-c2nc3cn[nH]cc-3n2)c1F>>Fc1cccc(-c2nc3cnn(Cc4cc(-c5ccc(CN6CCCCC6)cc5)no4)cc-3n2)c1F",
        "output": "997"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "N#Cc1cc(Br)c2c(c1)cc1n2CCCNC1=O.N#Cc1cccc(B(O)O)c1>>N#Cc1cccc(-c2cc(C#N)cc3cc4n(c23)CCCNC4=O)c1",
        "output": "833"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.O=C1CC(=P(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)O1>>CCOC(=O)C(CC(=O)O)=P(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "139"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CCOC(=O)Cc1c[nH]c2cccc([N+](=O)[O-])c12.O=C1CCC(=O)N1Br>>CCOC(=O)Cc1c(Br)[nH]c2cccc([N+](=O)[O-])c12",
        "output": "779"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.COC(=O)c1cc(Br)cc2ccccc12.Cc1ccccc1.[H-]>>OCc1cc(Br)cc2ccccc12",
        "output": "444"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(CC)Cc1ccc(N)cc1.O.O=C1OC(=O)c2ccccc21>>CCOC(=O)C(CC)Cc1ccc(N2C(=O)c3ccccc3C2=O)cc1",
        "output": "475"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COC(=O)CBr.O.O=C([O-])[O-].O=[N+]([O-])c1cc(Br)cc(F)c1O.[K+].[K+]>>COC(=O)COc1c(F)cc(Br)cc1[N+](=O)[O-]",
        "output": "557"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)[C@@H]1CC[C@@H](Oc2cnccn2)CC1.NN.O>>NNC(=O)[C@@H]1CC[C@@H](Oc2cnccn2)CC1",
        "output": "164"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1C(=O)C(F)(F)CN(C2CCC2)c2nc(Nc3ccc(C(=O)NC4CCN(C(=O)OC(C)(C)C)CC4)cc3)ncc21.ClCCl.O=C(O)C(F)(F)F>>CN1C(=O)C(F)(F)CN(C2CCC2)c2nc(Nc3ccc(C(=O)NC4CCNCC4)cc3)ncc21",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(C)=O.CCc1c(OC)cc(C)c(C=O)c1O.COc1c(Br)cc(CO)c(O)c1C.[BH4-].[Na+]>>CCc1c(OC)cc(C)c(CO)c1O",
        "output": "356"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "NCCc1c[nH]c2ccccc12.Oc1cccc(Nc2nc(Cl)ncc2F)c1>>Oc1cccc(Nc2nc(NCCc3c[nH]c4ccccc34)ncc2F)c1",
        "output": "544"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CC(=O)Cl.C=CCCN[C@@H]1CCCC[C@H]1NC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl>>C=CCCN(C(=O)C=C)[C@@H]1CCCC[C@H]1NC(=O)OC(C)(C)C",
        "output": "135"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN.CN(C)CC(=O)O>>CCNC(=O)CN(C)C",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc2oc(Cc3ccccc3)nc2c1.O.[H-]>>OCc1ccc2oc(Cc3ccccc3)nc2c1",
        "output": "444"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)CCCOC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1NCc1ccco1.[Na+].[OH-]>>NS(=O)(=O)c1cc(C(=O)OCCCC(=O)O)c(NCc2ccco2)cc1Cl",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(CO)COC1.CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O=C([O-])O.[Na+]>>Cc1ccc(S(=O)(=O)OCC2(C)COC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCCCCC.CCN(CC)CC.CCOC(C)=O.C[C@H](N)c1ccc(Br)cn1.ClCCl>>C[C@H](NC(=O)OC(C)(C)C)c1ccc(Br)cn1",
        "output": "631"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCOP(C)(=O)Cc1ccc(Nc2cc(Oc3ccc(N)c4ccccc34)ccn2)cc1OC.COc1c(NC(=O)Oc2ccccc2)cc(C(C)(C)C)cc1NS(C)(=O)=O>>CCOP(C)(=O)Cc1ccc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)cc(NS(C)(=O)=O)c4OC)c4ccccc34)ccn2)cc1OC",
        "output": "965"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCC2=NCCCN2CC1.CC#N.CCNCC1CCNC1.COc1c(F)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12>>CCNCC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2OC)C1",
        "output": "676"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1O.ClCCCCBr.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCCCCl",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CC(C)(C)O.CCNCC.Cc1ccc(I)cc1F.I[Cu]I.[Pd].c1ccc([PH+](c2ccccc2)c2ccccc2)cc1.c1ccc([PH+](c2ccccc2)c2ccccc2)cc1.c1ccc([PH+](c2ccccc2)c2ccccc2)cc1.c1ccc([PH+](c2ccccc2)c2ccccc2)cc1>>Cc1ccc(C#CC(C)(C)O)cc1F",
        "output": "664"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C=O)cn1.Cl>>O=Cc1ccc(O)nc1",
        "output": "408"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.Cl.OC1(c2ncccn2)CCC2(CC1)OCCO2>>O=C1CCC(O)(c2ncccn2)CC1",
        "output": "251"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.NS(=O)(=O)c1nc2ccc([N+](=O)[O-])cc2s1.[Pd]>>Nc1ccc2nc(S(N)(=O)=O)sc2c1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nn1nc(-c2ccc(Cl)cc2)c2ccccc2c1=O.O=C(Cl)[C@@H]1C[C@H]1c1ccccc1>>O=C(Nn1nc(-c2ccc(Cl)cc2)c2ccccc2c1=O)[C@@H]1C[C@H]1c1ccccc1",
        "output": "450"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.NC(Cc1ccccc1)P(O)O.O.O=C(Cl)OCc1ccccc1.[Na+].[OH-]>>O=C(NC(Cc1ccccc1)P(O)O)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=c1c(Br)c(O)ccn1Cc1cccc(F)c1>>O=c1c(Br)c(OS(=O)(=O)C(F)(F)F)ccn1Cc1cccc(F)c1",
        "output": "731"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.OC[C@@H](O)c1cccc(Cl)c1>>Cc1ccc(S(=O)(=O)OC[C@@H](O)c2cccc(Cl)c2)cc1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(Cc1c(I)cc(I)c(NC(=O)CCCCCNC(=O)CCl)c1I)C(=O)O.NCCNCCN>>CCC(Cc1c(I)cc(I)c(NC(=O)CCCCCNC(=O)CNCCNCCN)c1I)C(=O)O",
        "output": "330"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.ClCCl.O=C(Cl)OCc1ccccc1.O=[N+]([O-])c1ccc(N2CCNCC2)cc1>>O=C(OCc1ccccc1)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1",
        "output": "427"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO[C@H]1CN(C(C)=O)C[C@H]1Nc1nc(CC)c(-c2ccc(Cl)cc2Cl)nc1CC.CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1N[C@@H]1CNC[C@@H]1OCCF.COC(=O)Cl>>CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1N[C@@H]1CN(C(=O)OC)C[C@@H]1OCCF",
        "output": "219"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CN(C)C=O.CSc1ccnc(Cl)n1.N#Cc1cc(O)cc(C#N)c1.O.O=C([O-])[O-].[K+].[K+]>>CSc1ccnc(Oc2cc(C#N)cc(C#N)c2)n1",
        "output": "542"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCl.Nc1cccc(F)c1CO.O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1>>Nc1cccc(F)c1C=O",
        "output": "179"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1ccc(Cl)c(-c2ccccn2)c1.O=C(O)c1ccc(N2CCOCS2(=O)=O)cc1F>>O=C(Nc1ccc(Cl)c(-c2ccccn2)c1)c1ccc(N2CCOCS2(=O)=O)cc1F",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrBr.CC(C)(C)OC(=O)Oc1ccc2cccnc2c1.ClC(Cl)(Cl)Cl.c1ccncc1>>CC(C)(C)OC(=O)Oc1ccc2cc(Br)cnc2c1",
        "output": "292"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1ccc(N(c2ccc(-c3ccccc3)cc2)c2ccccc2-c2ccccc2)cc1.C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.ClCCl.[K+]>>CC1(C)OB(c2ccc(N(c3ccc(-c4ccccc4)cc3)c3ccccc3-c3ccccc3)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1onc(-c2ccccc2)c1CNc1ccc(C(=O)O)cn1.NC1CC1>>Cc1onc(-c2ccccc2)c1CNc1ccc(C(=O)NC2CC2)cn1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN=C=NCCCN(C)C.COc1ccccc1-c1nc(CC(=O)O)cn1-c1ccc(Cl)cc1.Cl.Nc1ccccc1N.c1ccncc1>>COc1ccccc1-c1nc(CC(=O)Nc2ccccc2N)cn1-c1ccc(Cl)cc1",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)[N+](=[N-])C(=O)OC(C)(C)C.CC(O)c1ccc2ccccc2n1.Cn1cc(-c2ccncc2)c(-c2ccc(O)cc2)n1.[Na+].[OH-].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(Oc1ccc(-c2nn(C)cc2-c2ccncc2)cc1)c1ccc2ccccc2n1",
        "output": "550"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)C(C)(C)Br.Cc1[nH]c2ccc(O)cc2c1CCc1ccc(Cl)cc1>>CCOC(=O)C(C)(C)Oc1ccc2[nH]c(C)c(CCc3ccc(Cl)cc3)c2c1",
        "output": "305"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)c1ccc(CNC(=O)c2cc(F)cc(F)c2)cn1.Cl.O.[K+].[OH-]>>O=C(NCc1ccc(C(=O)O)nc1)c1cc(F)cc(F)c1",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=O.CC#N.Cl.NC(=O)Cc1nn(C2CCNCC2)c2ccccc12.O=C([O-])O.[BH3-]C#N.[Na+].[Na+]>>CN1CCC(n2nc(CC(N)=O)c3ccccc32)CC1",
        "output": "217"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "B.C1CCOC1.CO.COc1ccc2ncc3c(c2n1)OC([C@@H]1CC[C@@H](N)CC1)C(=O)N3.CSC.ClCCl>>COc1ccc2ncc3c(c2n1)OC([C@@H]1CC[C@@H](N)CC1)CN3",
        "output": "363"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)n1c(C#N)cc2cc(C3(Cc4ccccc4)CCNC3)ccc21.COc1cccc(OC)c1.ClCCl.O=C(O)C(F)(F)F>>N#Cc1cc2cc(C3(Cc4ccccc4)CCNC3)ccc2[nH]1",
        "output": "848"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN.O=C(O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(Cl)cc2Cl)cc1>>CNC(=O)c1ccc(S(=O)(=O)Nc2ccccc2Oc2ccc(Cl)cc2Cl)cc1",
        "output": "835"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CC1CCc2c1[nH]c1ccc(-c3noc(-c4cc(C(F)(F)F)cc(N(CC)CC)n4)n3)cc21.CO.Cl.O.[Na+].[OH-]>>CCN(CC)c1cc(C(F)(F)F)cc(-c2nc(-c3ccc4[nH]c5c(c4c3)CCC5CC(=O)O)no2)n1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(=O)N1c2cc3c(cc2[C@H](N)C[C@@H]1C)CCC3.ClC(Cl)Cl.ClCCCl.O=Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1.[Na+]>>CCOC(=O)N1c2cc3c(cc2[C@H](NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C[C@@H]1C)CCC3",
        "output": "683"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCc1cc(OCCCBr)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1.CN>>CCc1cc(OCCCNC)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1",
        "output": "147"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)CC1CCCc2c(-c3ccc(C(F)(F)F)cc3F)cncc21.[H-]>>OCCC1CCCc2c(-c3ccc(C(F)(F)F)cc3F)cncc21",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCCN.CCN(CC)CC.O=C(Cl)c1cnc2cc(OCc3cccc(Cl)c3)ccc2c1>>CC(C)(C)OC(=O)NCCNC(=O)c1cnc2cc(OCc3cccc(Cl)c3)ccc2c1",
        "output": "353"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COCCBr.O=C1S/C(=C\\c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)C(=O)N1C1CCNCC1>>COCCN1CCC(N2C(=O)S/C(=C\\c3ccc4c(cnn4Cc4ccc(Cl)cc4C(F)(F)F)c3)C2=O)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1ccc(C=Cc2ccc(OCOC)c(OCOC)c2)cc1.CO.[Na+].[OH-]>>COCOc1ccc(C=Cc2ccc(C(=O)O)cc2)cc1OCOC",
        "output": "5"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CC1(C)CC(N)CC(C)(C)N1.O=C1OC(=O)c2ccccc21>>CC1(C)CC(N2C(=O)c3ccccc3C2=O)CC(C)(C)N1",
        "output": "341"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)c1ccc2c(c1)CC(C)(NC(=O)c1ccccc1)C2.CCO.Cl.[Pd]>>CCc1ccc2c(c1)CC(C)(NC(=O)c1ccccc1)C2",
        "output": "92"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CNC.CS(=O)(=O)OCCCc1cccc(-c2cc(N3CCN(c4ncccc4C(F)(F)F)CC3)nc(N3CCOCC3)n2)c1>>CN(C)CCCc1cccc(-c2cc(N3CCN(c4ncccc4C(F)(F)F)CC3)nc(N3CCOCC3)n2)c1",
        "output": "496"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)Cc1ccc(Sc2ccc(C#N)cc2)cc1.Cl.[Na+].[OH-]>>N#Cc1ccc(Sc2ccc(CC(=O)O)cc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C[C@H](O)[C@@H](N)Cc1ccccc1.CCN(C(C)C)C(C)C.CCOP(=O)(OCC)On1nnc2ccccc2c1=O.CC[C@H](C)[C@H](NC(=O)OC)C(=O)O>>CC[C@H](C)[C@H](NC(=O)OC)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.NC(CCO)c1ccc(Cl)cc1>>CC(C)(C)OC(=O)NC(CCO)c1ccc(Cl)cc1",
        "output": "686"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1cc(=O)c2ccc(O)cc2o1.CCOCC.ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>CCOC(=O)c1cc(=O)c2ccc(OS(=O)(=O)C(F)(F)F)cc2o1",
        "output": "731"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCCCN.CCN(C(C)C)C(C)C.ClCCl.O=C(Cl)c1ccc(CCl)cc1>>CCCCCCCCCCCCNC(=O)c1ccc(CCl)cc1",
        "output": "271"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CC1OCCc2c(Br)cccc21.CON1CCN(c2ccccc2)CC1.COc1ccc(N2CCN(C(=O)CC3OCCc4c(Br)cccc43)CC2)cc1.O=C(O)CC1OCCc2c(Br)cccc21.OCCc1ccccc1Br>>COc1ccc(N2CCN(CCC3OCCc4c(Br)cccc43)CC2)cc1",
        "output": "112"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.C=C1CCC(CC(C)C)(C(=O)OC)C1.O.O.[Li+].[OH-]>>C=C1CCC(CC(C)C)(C(=O)O)C1",
        "output": "361"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.CC[Al](Cl)CC.COc1cc(NC(=O)c2nc(C(C)C)cs2)cc(OC)c1.ClCCl>>COc1cc(NC(=O)c2nc(C(C)C)cs2)c(C(C)=O)c(OC)c1",
        "output": "31"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCC.COc1ccccc1.CS(=O)(=O)O.ClCCl.O=C(N[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)OCc1ccccc1>>N[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O",
        "output": "128"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1=COCCC1.CSc1nccc(CO)n1.Cc1ccc(S(=O)(=O)O)cc1.ClCCl>>CSc1nccc(COC2CCCCO2)n1",
        "output": "306"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCCO.COC(=O)Cc1ccc(O)cc1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CCCc1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCCOc1ccc(CC(=O)O)cc1",
        "output": "928"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1cc(C)cc([N+](=O)[O-])c1O.CCO.[Pt]>>CC(=O)c1cc(C)cc(N)c1O",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cc1cc(-n2ccc(OCc3ccccc3)cc2=O)ccc1[N+](=O)[O-].O.[Cl-].[Fe].[NH4+]>>Cc1cc(-n2ccc(OCc3ccccc3)cc2=O)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=[N+]([O-])c1ccc(F)cc1O.c1ccncc1>>O=[N+]([O-])c1ccc(F)cc1OS(=O)(=O)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ncc(-c2ccnc(NC3CCNCC3)n2)n1C(C)C.ClCCl.O=S(=O)(Cl)CCCCl>>Cc1ncc(-c2ccnc(NC3CCN(S(=O)(=O)CCCCl)CC3)n2)n1C(C)C",
        "output": "584"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN=C=NCCCN(C)C.ClCCl.Nc1ccccc1.O=C(O)[C@@H]1CN(Cc2ccccc2)C[C@@H]1Cc1ccccc1.On1nnc2ccccc21>>O=C(Nc1ccccc1)[C@@H]1CN(Cc2ccccc2)C[C@@H]1Cc1ccccc1",
        "output": "365"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.ClCCl.OC1CC2CCC1c1ccccc12>>O=C1CC2CCC1c1ccccc12",
        "output": "87"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)OB(c2ccc(NS(C)(=O)=O)cc2)OC1(C)C.N#Cc1ccccc1COc1cc(Br)cnc1N>>CS(=O)(=O)Nc1ccc(-c2cnc(N)c(OCc3ccccc3C#N)c2)cc1",
        "output": "938"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOc1c(C(C)=O)cc(Cl)c(C#N)c1Br.CO.[BH4-].[Na+]>>CCOc1c(C(C)O)cc(Cl)c(C#N)c1Br",
        "output": "24"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)O)cn1.NCCO.O=C(O)c1ccc(OCc2conc2-c2ccc(Cl)cc2)nc1>>O=C(NCCO)c1ccc(OCc2conc2-c2ccc(Cl)cc2)nc1",
        "output": "674"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N1CCN(CCCO)CC1.CCOC(=O)N=NC(=O)OCC.COc1cc2c(Cl)ncnc2cc1O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc2c(Cl)ncnc2cc1OCCCN1CCN(C(C)=O)CC1",
        "output": "478"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1noc(-c2ccc(Br)cc2)c1C(O)c1cccc(Cc2ccccc2)n1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4C(O)c4cccc(Cc5ccccc5)n4)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CO.CS(=O)(=O)Nc1ccccc1N1CCN(Cc2ccccc2)CC1.Cl.[Pd]>>CS(=O)(=O)Nc1ccccc1N1CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)c1ccccc1.Nc1nc(O)cc(-c2ccncc2)n1.O=P(Cl)(Cl)Cl>>Nc1nc(Cl)cc(-c2ccncc2)n1",
        "output": "168"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)CCCC(C)Br.N#Cc1ccc(O)cc1>>CC(C)CCCC(C)Oc1ccc(C#N)cc1",
        "output": "153"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCNc1ccccc1-3.Cl.O.[Na+].[OH-]>>O=C(O)c1ccc2c(C3CCCCC3)c3n(c2c1)CCNc1ccccc1-3",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCO.COc1ccc(COc2cccc([N+](=O)[O-])c2N)cc1.[Fe]>>COc1ccc(COc2cccc(N)c2N)cc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C=CC(=O)Cl.C=COCCCCO.CCN(CC)CC>>C=COCCCCOC(=O)C=C",
        "output": "320"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNC.Cl.F[P-](F)(F)(F)(F)F.O=C(O)/C=C/c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12>>CN(C)C(=O)/C=C/c1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12",
        "output": "811"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Clc1cc(Br)ccc1CBr.OCc1ccc(Br)cc1Cl.[Cl-].[H-].[NH4+].[Na+]>>Clc1cc(Br)ccc1COCc1ccc(Br)cc1Cl",
        "output": "464"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)N(CCCCOCC(=O)O)c1cnc(-c2ccccc2)c(-c2ccccc2)n1.CCN(CC)CC.CCOC(=O)Cl.N>>CC(C)N(CCCCOCC(N)=O)c1cnc(-c2ccccc2)c(-c2ccccc2)n1",
        "output": "313"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCC(N)(CC)C(=O)OCC.CCOCC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CCCCC(N)(CC)CO",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1c(OC)nc(OC)nc1C(=O)c1cc(C)cc(CO)c1.ClCCl.[Mn+4].[O-2].[O-2]>>CCc1c(OC)nc(OC)nc1C(=O)c1cc(C)cc(C=O)c1",
        "output": "179"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccccc1.O=C(Cl)CCCCCl>>COc1ccc(C(=O)CCCCCl)cc1",
        "output": "31"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCN(CCC(=O)OCC)C(=O)OC(C)(C)C.CO.O=S(=O)([O-])O.[K+].[Li+].[OH-]>>C=CCN(CCC(=O)O)C(=O)OC(C)(C)C",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)Cl.Cc1ccc(C2Sc3ccccc3NC(=O)C2CO)cc1.O.c1ccncc1>>Cc1ccc(C2Sc3ccccc3NC(=O)C2COS(C)(=O)=O)cc1",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCOCC.CS(=O)(=O)Cl.Cl.ClCCl.[N-]=[N+]=N[C@@H](Cc1ccccc1)[C@@H](O)[C@H](O)[C@H](Cc1ccccc1)N=[N+]=[N-]>>CS(=O)(=O)O[C@H]([C@H](Cc1ccccc1)N=[N+]=[N-])[C@H](O)[C@H](Cc1ccccc1)N=[N+]=[N-]",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCC2=NCCCN2CC1.C1CCOC1.COC(=O)c1cnc(Br)s1.O=C(c1ccccc1C(F)(F)F)N1CCNCC1>>COC(=O)c1cnc(N2CCN(C(=O)c3ccccc3C(F)(F)F)CC2)s1",
        "output": "657"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.COc1ccc2ncc(=O)n(CCN3CCC(NC(=O)OC(C)(C)C)CC3)c2n1.Cl.ClCCl>>COc1ccc2ncc(=O)n(CCN3CCC(N)CC3)c2n1",
        "output": "538"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.O=C(O)CCCCCCC(=O)O>>O=C1CCCCCCC(=O)O1",
        "output": "436"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.Cc1ccc(S(=O)(=O)OCCCNC2=C(c3ccccc3)S(=O)(=O)N(C(C)(C)C)C2=O)cc1.Oc1ccncc1>>CC(C)(C)N1C(=O)C(NCCCOc2ccncc2)=C(c2ccccc2)S1(=O)=O",
        "output": "438"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1=COCCC1.CCCCCCCCCCC[C@@H](O)C[C@H](O[Si](C)(C)C(C)(C)C)[C@H](CCCCCC)C(=O)OCc1ccccc1.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O>>CCCCCCCCCCC[C@H](C[C@H](O[Si](C)(C)C(C)(C)C)[C@H](CCCCCC)C(=O)OCc1ccccc1)OC1CCCCO1",
        "output": "306"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3ccc(C(=O)OC(C)(C)C)cc3)c2)=C(C)C1=O.O=CO>>COC1=C(OC)C(=O)C(Cc2ccc(OC(C)=O)c(C(=O)Nc3ccc(C(=O)O)cc3)c2)=C(C)C1=O",
        "output": "752"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)CCCCBr.Cc1c(N(Cc2ccccc2)Cc2ccc(Oc3cccc(O)c3)cc2)cccc1[N+](=O)[O-]>>CCOC(=O)CCCCOc1cccc(Oc2ccc(CN(Cc3ccccc3)c3cccc([N+](=O)[O-])c3C)cc2)c1",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#CC(C)(C)C.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.N#Cc1cc([N+](=O)[O-])cc(Br)c1N.[Cu]I>>CC(C)(C)C#Cc1cc([N+](=O)[O-])cc(C#N)c1N",
        "output": "659"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN1CCCC1=O.Cc1nc2c(N)nc3ccccc3c2n1CCOCCN.O=C=Nc1ccccc1>>Cc1nc2c(N)nc3ccccc3c2n1CCOCCNC(=O)Nc1ccccc1",
        "output": "35"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)Cc1cccc(B(O)O)c1.Cc1noc(-c2ccc(O)cc2)c1NC(=O)O[C@H](C)c1ccccc1F>>COC(=O)Cc1cccc(Oc2ccc(-c3onc(C)c3NC(=O)O[C@H](C)c3ccccc3F)cc2)c1",
        "output": "920"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(=O)N(CCCN2CCCCC2)CC1.CO.Cl.ClCCl>>O=C1CCNCCN1CCCN1CCCCC1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CCOCC.COc1ccc(C(=O)Cl)cc1.COc1ccc(CC2CCNCC2)cc1OC1CCCC1>>COc1ccc(C(=O)N2CCC(Cc3ccc(OC)c(OC4CCCC4)c3)CC2)cc1",
        "output": "201"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(CN2CCN(c3cccc(Cl)c3)CC2C(=O)NC(C)C)cc1OC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1ccc(CN2CCN(c3cccc(Cl)c3)CC2CNC(C)C)cc1OC",
        "output": "490"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1cccc(C)c1C(=O)O.ClCCl>>Cc1cccc(O)c1C(=O)O",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.COc1c(C(=O)O)cc(C(C)(C)C)cc1[N+](=O)[O-].ClCCl.NC1CC1.O=C(Cl)C(=O)Cl.O=C([O-])O.[Na+]>>COc1c(C(=O)NC2CC2)cc(C(C)(C)C)cc1[N+](=O)[O-]",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)N1CCNCC1.CCN(C(C)C)C(C)C.ClC(Cl)Cl.O=C1c2ccccc2C(=O)N1CCCBr.[Cl-].[Na+]>>CC(C)N1CCN(CCCN2C(=O)c3ccccc3C2=O)CC1",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC1(O)CCCCC1Nc1nc(-c2cn(S(=O)(=O)c3ccccc3)c3ncc(Cl)cc23)ncc1F.CCOC(C)=O.C[O-].O.[Cl-].[Na+].[Na+]>>CC1(O)CCCCC1Nc1nc(-c2c[nH]c3ncc(Cl)cc23)ncc1F",
        "output": "831"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CSCCCNC(=O)c1cc([N+](=O)[O-])c(Sc2c(Cl)cncc2Cl)s1.O=C(OO)c1cccc(Cl)c1>>CS(=O)CCCNC(=O)c1cc([N+](=O)[O-])c(Sc2c(Cl)cncc2Cl)s1",
        "output": "13"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN(C)C=O.CNC.ClCCOc1cccc2c1c1cccc3c1n2C(c1ccccc1)CO3.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CN(C)CCOc1cccc2c1c1cccc3c1n2C(c1ccccc1)CO3",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.COc1ccc(O)cc1OC.N#CCBr.O=C([O-])[O-].[K+].[K+]>>COc1ccc(OCC#N)cc1OC",
        "output": "802"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=C(O)Cc1nc(-c2ccc(Cl)cc2)sc1C(=O)O.O=S(=O)(O)O>>COC(=O)Cc1nc(-c2ccc(Cl)cc2)sc1C(=O)O",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.CCN=C=NCCCN(C)C.COc1cccc(C(=O)O)c1C.Cl.ClC(Cl)Cl.ClCCl.On1nnc2ccccc21>>COc1cccc(C(=O)N2CCOCC2)c1C",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cnn2c(=O)cc(-c3ccc4c(cnn4CC)c3)[nH]c12.CS(C)=O.Cl.O.[Na+].[OH-]>>CCn1ncc2cc(-c3cc(=O)n4ncc(C(=O)O)c4[nH]3)ccc21",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.ClCCCCCBr.Nc1c(C(=O)c2ccc(F)cc2F)ccc(=O)n1-c1c(F)cc(O)cc1F.Nc1c(C(=O)c2ccc(F)cc2F)ccc(=O)n1-c1c(F)cc(OCCCCCI)cc1F.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>Nc1c(C(=O)c2ccc(F)cc2F)ccc(=O)n1-c1c(F)cc(OCCCCCCl)cc1F",
        "output": "75"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)C(Cc1cccc(OC)c1)c1cc(Cl)cc(Cl)c1.Cl.O.[Li+].[OH-]>>COc1cccc(CC(C(=O)O)c2cc(Cl)cc(Cl)c2)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.CCOC(=O)N1c2ccc(C(F)(F)F)cc2C(=O)CC1CC.CO.[BH4-].[Na+]>>CCOC(=O)N1c2ccc(C(F)(F)F)cc2C(O)CC1CC",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.CN1CCNCC1.COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCCC(=O)O.Cl>>COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCCC(=O)N1CCN(C)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.N#Cc1ccc(N)nc1.N#Cc1ccc(NCl)nc1.O=C1CCC(=O)N1Cl>>N#Cc1cnc(N)c(Cl)c1",
        "output": "743"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)CCCCCOc1ccc2nc(S(=O)(=O)Cc3ccccc3)n(-c3ccc(C)cc3)c2c1.COCCCN>>COCCCNC(=O)CCCCCOc1ccc2nc(S(=O)(=O)Cc3ccccc3)n(-c3ccc(C)cc3)c2c1",
        "output": "392"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CCOC(C)=O.CO.NC(N)=O.Nc1cc(Cl)c(Cl)c(Cl)c1.O.O=N[O-].[I-].[K+].[Na+]>>Clc1cc(I)cc(Cl)c1Cl",
        "output": "200"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CNC1CCN(C(=O)OC(C)(C)C)CC1.COCC(=O)Cl.ClCCl>>COCC(=O)N(C)C1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "125"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CNC.NC(=O)CCCCBr>>CN(C)CCCCC(N)=O",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC1CC(N)CC(CC)N1C(=O)OC(C)C.CCN(C(C)C)C(C)C.CN(C)C=O.Clc1ncc(Br)cn1.O>>CCC1CC(Nc2ncc(Br)cn2)CC(CC)N1C(=O)OC(C)C",
        "output": "544"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.COc1cc(CN)ccc1O.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1cccc(NS(=O)(=O)c2ccccc2)c1>>COc1cc(CNC(=O)c2cccc(NS(=O)(=O)c3ccccc3)c2)ccc1O",
        "output": "753"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCSc1ccc(N)c(Cl)c1Cl.CN(C)C=O.C[C@@](O)(C(=O)O)C(F)(F)F.ClCCl.O=C(Cl)C(=O)Cl.c1ccc(-c2cccc(-c3ccccc3)n2)cc1>>CCSc1ccc(NC(=O)[C@@](C)(O)C(F)(F)F)c(Cl)c1Cl",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCn1cc(-c2ccnc3[nH]c(C4=CCN(C(=O)OC(C)(C)C)CC4)cc23)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)n1.Cl>>CCn1cc(-c2ccnc3[nH]c(C4=CCNCC4)cc23)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)n1",
        "output": "800"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.CCCI.COc1cccc(CCNCCc2c[nH]cn2)c1.Cl.Cl.O=C([O-])[O-].[K+].[K+]>>CCCN(CCc1cccc(OC)c1)CCc1c[nH]cn1",
        "output": "184"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)C(=O)Nc1ccc(F)c(C2CCN(CCCN)CC2)c1.O=C(O)C1(c2ccc(F)cc2)CCCC1>>CC(C)C(=O)Nc1ccc(F)c(C2CCN(CCCNC(=O)C3(c4ccc(F)cc4)CCCC3)CC2)c1",
        "output": "230"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1ccc(-n2cnnn2)nc1.O=C(Cl)Oc1ccccc1.c1ccncc1>>O=C(Nc1ccc(-n2cnnn2)nc1)Oc1ccccc1",
        "output": "763"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COCCNC(=O)c1ccc(CCC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(OC)n4Cc3ccccn3)c2Cl)cc1.CS(=O)(=O)Nc1ccc(CCC(=O)O)cc1.Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CN)c3Cl)c2n1>>Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CCc4ccc(NS(C)(=O)=O)cc4)c3Cl)c2n1",
        "output": "133"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)C(C)(C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.Cc1noc(-c2ccc(Br)cc2)c1CSCCc1ccccc1>>COC(=O)C(C)(C)c1ccc(-c2ccc(-c3onc(C)c3CSCCc3ccccc3)cc2)cc1",
        "output": "933"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1CCc2nc(N3N=C(c4cc(F)ccc4F)SC3(CCCN=[N+]=[N-])c3ccccc3)sc2C1.CO.CO.Cl.[Pd]>>CN1CCc2nc(N3N=C(c4cc(F)ccc4F)SC3(CCCN)c3ccccc3)sc2C1",
        "output": "89"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.ClCCl.O=S(=O)(Nc1nncs1)c1cc(Cl)c(Oc2ccc(-c3ccccc3C(F)(F)F)cc2-c2ccnn2C2CNC2)cc1F.[Na+]>>CN1CC(n2nccc2-c2cc(-c3ccccc3C(F)(F)F)ccc2Oc2cc(F)c(S(=O)(=O)Nc3nncs3)cc2Cl)C1",
        "output": "217"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.NN.O.O=C(CCCc1ccccc1)N1CCc2nnc(Cl)cc2C1.O=C(O)c1cc(O)ccc1O>>NNc1cc2c(nn1)CCN(C(=O)CCCc1ccccc1)C2",
        "output": "284"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N(Cc1nc2c(c(=O)[nH]1)COCC2)Cc1cccs1.CO.Cl>>O=c1[nH]c(CNCc2cccs2)nc2c1COCC2",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)CCCOc1ccc([N+](=O)[O-])cc1F.CN1CCC[C@H]1COc1ccc(Nc2nccc(-c3c(-c4cccc(NC(=O)c5c(F)cccc5F)c4)nn4ccccc34)n2)cc1F>>CN(C)CCCOc1ccc(N)cc1F",
        "output": "202"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.Cc1ccccc1.O=C1CCC(=O)N1Br.c1ccc(-n2c3ccccc3c3ccccc32)cc1>>Brc1ccc2c(c1)c1ccccc1n2-c1ccccc1",
        "output": "4"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)O)CC1.C[C@H](N)C1CCCCC1>>CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)N[C@@H](C)C2CCCCC2)CC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)c1ccncc1.COc1ccccc1-c1cc(C(N)=O)c2[nH]c3ccc(C(=O)O)cc3c2c1.F[P-](F)(F)(F)(F)F.OCC1CNCCO1>>COc1ccccc1-c1cc(C(N)=O)c2[nH]c3ccc(C(=O)N4CCOC(CO)C4)cc3c2c1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCCCCBr.ClCCl.O.OCCc1nc2ccccc2o1.[Na+].[OH-]>>BrCCCCCCOCCc1nc2ccccc2o1",
        "output": "95"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)CO.FC1(F)CCN(c2nc(Cl)nc3c2ncn3C2CCCCO2)C1.[H-].[Na+]>>CC(C)(C)COc1nc(N2CCC(F)(F)C2)c2ncn(C3CCCCO3)c2n1",
        "output": "213"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)COc1ccc(C(=O)CCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C.O.[BH4-].[Na+]>>CCOC(=O)COc1ccc(C(O)CCc2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C",
        "output": "24"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC[SiH](CC)CC.COc1cc(O)c2c(c1C(N)=O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.O=C(O)C(F)(F)F.O=Cc1cc(C(=O)C2CC2)cc2ccccc12>>COc1cc(O)c2c(c1C(=O)NCc1cc(C(=O)C3CC3)cc3ccccc13)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C",
        "output": "996"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCN1.CC(C)=O.O=C(O)c1cc(Cl)ccc1[N+](=O)[O-].O=S(Cl)Cl>>O=C(c1cc(Cl)ccc1[N+](=O)[O-])N1CCOCC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1CCC(C(C)C)C(C(=O)Cl)C1.CCN(CC)CC.ClCCl.NCCc1ccccc1Br>>CC1CCC(C(C)C)C(C(=O)NCCc2ccccc2Br)C1",
        "output": "45"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C1CCNCC1)S(=O)(=O)c1cccc(C(F)(F)F)c1.CCOC(C)=O.ClCCl.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1Br>>CC(C)(C1CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2Br)CC1)S(=O)(=O)c1cccc(C(F)(F)F)c1",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COC(=O)c1c[nH]cc1C.I[Cu]I.Ic1ccccc1.O=C(O)[C@@H]1CCCN1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cn(-c2ccccc2)cc1C",
        "output": "267"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cn1cnc2c1CC(C(=O)O)N(S(=O)(=O)c1ccc(-c3ccc([N+](=O)[O-])cc3)cc1)C2.[Pd]>>Cn1cnc2c1CC(C(=O)O)N(S(=O)(=O)c1ccc(-c3ccc(N)cc3)cc1)C2",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CC(=O)N(C)C.O=C(O)C(CCc1ccccc1)NC1CCc2ccccc2NC1=O.O=C([O-])O.[Na+]>>O=C1Nc2ccccc2CCC1NC(CCc1ccccc1)C(=O)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)N(C)C.CN(C)C=O.Cc1cc(C(=O)O)n(C(C)C)n1.Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)nn3c2)c1.O=C(Cl)C(=O)Cl>>Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)c2)n(C(C)C)n1",
        "output": "844"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.CCOC(=O)c1cc(=O)c2c(OCC(O)CSC)cccc2o1.Cl.[Na+].[OH-]>>CSCC(O)COc1cccc2oc(C(=O)O)cc(=O)c12",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)c1ccc(Cl)c(SC)c1OC.O.[Li+].[OH-]>>COc1c(C(=O)O)ccc(Cl)c1SC",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccccc1.Cn1c(C2CC2)nc2ccc(-n3ccc(OCc4ccccc4)cc3=O)cc21.O=C(O)C(F)(F)F>>Cn1c(C2CC2)nc2ccc(-n3ccc(O)cc3=O)cc21",
        "output": "23"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.NC1CC2CC1C1C=CCC21.NC1CC2CC1C1CC=CC21.[Pd]>>NC1CC2CC1C1CCCC21",
        "output": "143"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2ccc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)cc2)cc1F.Cl.O.O.[Li]O>>O=C(O)c1ccc(-c2ccc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)cc2)cc1F",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCCN.ClCCl.O=C(Cl)Cc1ccccc1>>CC(C)(C)OC(=O)NCCNC(=O)Cc1ccccc1",
        "output": "45"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NC1(CC#N)CCCC1.CCOCC.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>CC(C)(C)OC(=O)NC1(CCN)CCCC1",
        "output": "246"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(=O)OCc1c(-c2cc(Nc3ccc(C(=O)N(C)C)cn3)c(=O)n(C)n2)cccc1-n1ncc2cc(C(C)(C)C)cc(F)c2c1=O.[Li+].[OH-]>>CN(C)C(=O)c1ccc(Nc2cc(-c3cccc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3CO)nn(C)c2=O)nc1",
        "output": "497"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cn(-c2ccccc2)nc1OCc1oc2cc(OCc3nc(-c4ccccc4)oc3C)ccc2c1-c1ccccc1.CCOC(C)=O.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>Cc1oc(-c2ccccc2)nc1COc1ccc2c(-c3ccccc3)c(COc3nn(-c4ccccc4)cc3CO)oc2c1",
        "output": "471"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1CCCC1=O.COc1cc(Cl)cc(C(=O)N2CCc3cc(F)ccc32)n1.O=c1[nH]c2ncccc2n1C1CCNCC1>>COc1cc(N2CCC(n3c(=O)[nH]c4ncccc43)CC2)cc(C(=O)N2CCc3cc(F)ccc32)n1",
        "output": "398"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCOC(=O)Cc1ccc(N)cc1.ClCCl.O=C(O)[C@H](Cc1ccccc1)NS(=O)(=O)c1ccc(Br)cc1>>CCOC(=O)Cc1ccc(NC(=O)[C@H](Cc2ccccc2)NS(=O)(=O)c2ccc(Br)cc2)cc1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cl.N#Cc1sccc1-c1cccc(-c2cnc3cc(C=O)ccn23)c1.NOCCO>>N#Cc1sccc1-c1cccc(-c2cnc3cc(C=NOCCO)ccn23)c1",
        "output": "30"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CNC(=O)c1ccc(Cc2nc3ccccc3[nH]2)cc1.O.[Al+3].[H-].[H-].[H-].[H-].[K+].[Li+].[OH-]>>CNCc1ccc(Cc2nc3ccccc3[nH]2)cc1",
        "output": "215"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)c1c[nH]c(-c2cc(Oc3cccc(N)c3)ccn2)c1.Cc1ccoc1C(=O)O.Cl.F[P-](F)(F)(F)(F)F.O>>COC(=O)c1c[nH]c(-c2cc(Oc3cccc(NC(=O)c4occc4C)c3)ccn2)c1",
        "output": "860"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COCCOC1CCNCC1.Cl.O=C(N[C@@H](Cc1ccc(F)cc1)C(=O)O)c1cc2cc(Cl)ncc2[nH]1>>COCCOC1CCN(C(=O)[C@H](Cc2ccc(F)cc2)NC(=O)c2cc3cc(Cl)ncc3[nH]2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)[C@H](C)Nc1cc(Cl)cc(-c2ccc(Oc3ccc(F)cc3)cc2)n1.N>>C[C@H](Nc1cc(Cl)cc(-c2ccc(Oc3ccc(F)cc3)cc2)n1)C(N)=O",
        "output": "432"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[O-].CC(C)C1=CC(C(C)C)=C(c2ccccc2)C(C(C)C)(P(C2CCCCC2)C2CCCCC2)C1.COC1CCNCC1.Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Nc1cc(Br)cnc1N1CCOCC1.Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>COC1CCN(c2cnc(N3CCOCC3)c(Nc3c(C)c(-c4ccccn4)nc4cc(F)cc(F)c34)c2)CC1",
        "output": "597"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.CS(=O)(=O)Cl.Cn1cnc2c(C#N)nc(-c3ccc(OCCCO)c(C(F)(F)F)c3)cc21>>Cn1cnc2c(C#N)nc(-c3ccc(OCCCOS(C)(=O)=O)c(C(F)(F)F)c3)cc21",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCC(=O)N(C)c1ccc([N+](=O)[O-])cc1.[Pd]>>CCC(=O)N(C)c1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)N=C=O.Cl.FC(F)(F)c1ccccc1C(OC1CNC1)c1ccc(Cl)cc1>>CC(C)(C)NC(=O)N1CC(OC(c2ccc(Cl)cc2)c2ccccc2C(F)(F)F)C1",
        "output": "437"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.CCCCCC.COc1cc(O[Si](C)(C)C(C)(C)C)ccc1Br.Cl.[Li]CCCC>>COc1cc(O[Si](C)(C)C(C)(C)C)ccc1B(O)O",
        "output": "832"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1c(N)cc(C(C)(C)C)cc1NS(C)(=O)=O.COc1c(NC(=O)c2ccc(C)c(N=[N+]=[N-])c2)cc(C(C)(C)C)cc1NS(C)(=O)=O.Cc1c(F)cc(C(=O)O)cc1N=[N+]=[N-]>>COc1c(NC(=O)c2cc(F)c(C)c(N=[N+]=[N-])c2)cc(C(C)(C)C)cc1NS(C)(=O)=O",
        "output": "50"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCC1CCNCC1.CCN(CC)CC.CCOC(C)=O.O=[N+]([O-])c1cncc(Br)c1Cl>>CC(C)(C)OC(=O)NCC1CCN(c2c(Br)cncc2[N+](=O)[O-])CC1",
        "output": "398"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)O.COC(=O)c1c(C)cccc1CO[C@@H]1CCC[C@H](OCc2nc(-c3ccc4ccccc4c3)oc2C)C1.Cl.[K+].[OH-]>>Cc1cccc(CO[C@@H]2CCC[C@H](OCc3nc(-c4ccc5ccccc5c4)oc3C)C2)c1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1cccnc1)C(=O)NC(CCCc1ccccc1)CCCc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>N[C@@H](Cc1cccnc1)C(=O)NC(CCCc1ccccc1)CCCc1ccccc1",
        "output": "431"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)C(F)(F)CNc1c(N)cccc1NC(=S)Nc1ccc(Cl)cc1Cl.[BH4-].[Li+]>>Nc1cccc(NC(=S)Nc2ccc(Cl)cc2Cl)c1NCC(F)(F)CO",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)c1cc(Oc2ccc(C(=O)N3CCC3)cc2F)cc(O[C@@H](C)CO)c1.O.[Li+].[OH-]>>C[C@@H](CO)Oc1cc(Oc2ccc(C(=O)N3CCC3)cc2F)cc(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1c(SC)cc(F)cc1-c1c(Cl)cccc1Cl.ClCCl.O=C([O-])O.[Na+]>>CSc1cc(F)cc(-c2c(Cl)cccc2Cl)c1O",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)c1onc(-c2c(Cl)cccc2Cl)c1COc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.CCOC(=O)c1nccc2cc(Br)ccc12.CCOC(C)=O.O.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1nccc2cc(-c3ccc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)cc3)ccc12",
        "output": "933"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1cccc(CN2CCC(CCc3cccc4c3OCO4)CC2)n1.CO.C[O-].O.[Na+]>>COc1cccc(CN2CCC(CCc3cccc4c3OCO4)CC2)n1",
        "output": "551"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CN1CCNCC1.Nc1cc(Cl)ccc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>CN1CCN(c2ccc([N+](=O)[O-])c(N)c2)CC1",
        "output": "105"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCC(N)CC1.COc1cc(Nc2ncc3c(n2)N(C2CCCC2)CC(F)(F)C(=O)N3C)ccc1C(=O)O.F[P-](F)(F)(F)(F)F>>COc1cc(Nc2ncc3c(n2)N(C2CCCC2)CC(F)(F)C(=O)N3C)ccc1C(=O)NC1CCN(C)CC1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CN)n23)CC1.O=C=Nc1ccccc1>>CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CNC(=O)Nc4ccccc4)n23)CC1",
        "output": "35"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.O.O=C([O-])[O-].O=Cc1cc(Cl)cc(F)c1O.[K+].[K+]>>COc1c(F)cc(Cl)cc1C=O",
        "output": "62"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CS(=O)(=O)c1nccc(-n2nc(-c3ccccc3)cc2-c2ccccc2)n1.O=C1CCC(=O)N1Br>>CS(=O)(=O)c1nccc(-n2nc(-c3ccccc3)c(Br)c2-c2ccccc2)n1",
        "output": "620"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)Cl.COCCOC.Nc1ccccc1OC(F)(F)F.O.[H-].[Na+]>>CCOC(=O)Nc1ccccc1OC(F)(F)F",
        "output": "102"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.Cl.NC(=O)c1ccc(CCC2OCCO2)cc1>>NC(=O)c1ccc(CCC=O)cc1",
        "output": "740"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCCCCC.CCOC(C)=O.CNC1CCN(Cc2ccccc2)CC1.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)nc1Cl.[K+].[K+]>>CN(c1nc(Cl)ccc1[N+](=O)[O-])C1CCN(Cc2ccccc2)CC1",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOCC.COC(=O)CCCc1cccs1.Cl.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCCc1cccs1",
        "output": "343"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CCN(c1cc(-c2cccc(C=O)c2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1.ClCCl.[Na+]>>CCN(c1cc(-c2cccc(CN3CCOCC3)c2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1",
        "output": "567"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.Cc1cccc(Br)c1O.Cl.N#Cc1cc(S(=O)(=O)Nc2ncns2)ccc1F.O=C([O-])[O-].[K+].[K+]>>Cc1cccc(Br)c1Oc1ccc(S(=O)(=O)Nc2ncns2)cc1C#N",
        "output": "564"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.OCc1ccc(OCc2ccccc2)cc1.[Mn+4].[O-2].[O-2]>>O=Cc1ccc(OCc2ccccc2)cc1",
        "output": "179"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.Cc1ccc(C)nc1.OO.[Na+].[OH-]>>Cc1ccc(C)[n+]([O-])c1",
        "output": "396"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCN(CC)CC.CS(=O)(=O)Cl.O=C(N[C@H]1CC[C@H](O)C1)c1ccc(-c2ccccc2)cc1>>CS(=O)(=O)O[C@H]1CC[C@H](NC(=O)c2ccc(-c3ccccc3)cc2)C1",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COCc1cc(CN)c(C2CCC2)cn1.Cc1c(-c2cnn(C)c2)nn(-c2ccccc2)c1NC(=O)Oc1ccccc1>>COCc1cc(CNC(=O)Nc2c(C)c(-c3cnn(C)c3)nn2-c2ccccc2)c(C2CCC2)cn1",
        "output": "488"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C=CCn1c(=O)n([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c21.CC(=O)Oc1ccc(C=O)cc1.CCOCC.[Cl-].[Cl-].[Zn+2]>>C=CCn1c(=O)n([C@@H]2O[C@H](CO)[C@H]3OC(c4ccc(OC(C)=O)cc4)O[C@H]32)c2nc(N)[nH]c(=O)c21",
        "output": "117"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCC2=NCCCN2CC1.C=C[C@@H]1C[C@]1(NC(=O)C1CN(C(=O)OC(C)(C)C)Cc2c[nH]nc21)C(=O)O.ClCCCl.NS(=O)(=O)C1CC1.O=C(n1ccnc1)n1ccnc1>>C=C[C@@H]1C[C@]1(NC(=O)C1CN(C(=O)OC(C)(C)C)Cc2c[nH]nc21)C(=O)NS(=O)(=O)C1CC1",
        "output": "644"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.O=C(CCOCCc1ccccc1)N1CC(CO)C1>>OCC1CN(CCCOCCc2ccccc2)C1",
        "output": "112"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(O)c1cc(-c2ccc(Cl)cc2)nc(Cl)n1.Cc1nsc(N2CCC(N)CC2)n1>>Cc1nsc(N2CCC(Nc3nc(-c4ccc(Cl)cc4)cc(C(C)(C)O)n3)CC2)n1",
        "output": "544"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc(C(=O)O)c2ccccc12.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>O=C(O)c1ccc(CBr)c2ccccc12",
        "output": "29"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O.O=Cc1ccc2c(c1)CCO2.[BH4-].[Na+]>>OCc1ccc2c(c1)CCO2",
        "output": "356"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.CNc1cc(F)ccc1[N+](=O)[O-].COc1cc(O)ccn1.O.O=C([O-])[O-].[Cs+].[Cs+]>>CNc1cc(Oc2ccnc(OC)c2)ccc1[N+](=O)[O-]",
        "output": "564"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C)CCCC(SCc2ccc(C#N)cc2)C1.CCO.N.[Ni]>>CC1(C)CCCC(SCc2ccc(CN)cc2)C1",
        "output": "175"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C(CCl)N[C@@H]1COc2nc([N+](=O)[O-])cn2C1.c1cc(OC2CCNCC2)ccc1OCCOC1CC1>>O=C(CN1CCC(Oc2ccc(OCCOC3CC3)cc2)CC1)N[C@@H]1COc2nc([N+](=O)[O-])cn2C1",
        "output": "340"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)c1c(C(F)(F)F)nc2cc(C(F)(F)F)ccc2c1O.[Na+].[OH-]>>O=C(O)c1c(C(F)(F)F)nc2cc(C(F)(F)F)ccc2c1O",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCC.CCOC(C)=O.CCOc1nc2cc(C(F)(F)F)ccc2c(O)c1C(=O)NCc1cccc(F)c1.CI.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCOc1nc2cc(C(F)(F)F)ccc2c(OC)c1C(=O)NCc1cccc(F)c1",
        "output": "62"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)O)CC1.C[C@H](N)c1cccc(F)c1>>CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)N[C@@H](C)c2cccc(F)c2)CC1",
        "output": "599"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCN(C1(C(=O)OC)CC1)S(=O)(=O)c1ccc(F)cc1.[Na+].[OH-]>>CCN(C1(C(=O)O)CC1)S(=O)(=O)c1ccc(F)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C=O)NC(=O)OC(C)(C)C.CC(C)C(N)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1.ClCCl.[Na+]>>CC(C)C(NCC(C)(C)NC(=O)OC(C)(C)C)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1",
        "output": "426"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CC(C(=O)O)C2)nc1C(F)F.NS(=O)(=O)c1ccc2ccccc2c1>>CCOC(=O)c1cc(C#N)c(N2CC(C(=O)NS(=O)(=O)c3ccc4ccccc4c3)C2)nc1C(F)F",
        "output": "801"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C4(CC#N)CNC4)c3)ncnc21.Cl.Cl.O=C(N[C@@H](C1CC1)C(F)(F)F)c1cnc(Cl)cn1.O=C([O-])O.[Na+]>>C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C4(CC#N)CN(c5cnc(C(=O)N[C@@H](C6CC6)C(F)(F)F)cn5)C4)c3)ncnc21",
        "output": "505"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.COC(=O)Cc1c(C(=O)c2snnc2C)[nH]c2ccc(Cl)cc12.Cl>>Cc1nnsc1C(=O)c1[nH]c2ccc(Cl)cc2c1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)OB(c2ccc(OCCOCc3ccccc3)c(NS(C)(=O)=O)c2)OC1(C)C.CCO.Cc1ccc(S(=O)(=O)n2cc(-c3c(C)nn(Cc4cccc(F)c4)c3C)c3cc(Br)cnc32)cc1.Cc1ccccc1.O.O=C([O-])[O-].[Na+].[Na+]>>Cc1ccc(S(=O)(=O)n2cc(-c3c(C)nn(Cc4cccc(F)c4)c3C)c3cc(-c4ccc(OCCOCc5ccccc5)c(NS(C)(=O)=O)c4)cnc32)cc1",
        "output": "938"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)N1CC(C)C(NC)C(C)C1.[Na+].[OH-]>>CNC1C(C)CNCC1C",
        "output": "283"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)Oc2cc(C=CC(=O)O)cnc2NC1=O.CNCc1cc2ccccc2n1C>>CN(Cc1cc2ccccc2n1C)C(=O)/C=C/c1cnc2c(c1)OC(C)(C)C(=O)N2",
        "output": "517"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NC12CC3CC(C1)NC(=O)C(C3)C2.CO>>CC(C)(C)OC(=O)NC12CC3CNC(CC(C3)C1)C2",
        "output": "112"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(CC)CC.COc1ccc(-n2nc(C)c3c(C(=O)O)cc(C)nc32)cc1.Cc1cc(C)c(N)cn1.O>>COc1ccc(-n2nc(C)c3c(C(=O)Nc4cnc(C)cc4C)cc(C)nc32)cc1",
        "output": "759"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNC1.CN(Cc1ccccc1)c1ccc(C(C)(CO)C(=O)O)cc1[N+](=O)[O-]>>CN(Cc1ccccc1)c1ccc(C(C)(CO)C(=O)N2CCCC2)cc1[N+](=O)[O-]",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Cl.COc1cc(N)ccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1.ClC(Cl)Cl.ClCCl>>COc1cc(NC(C)=O)ccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1",
        "output": "9"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCc1noc(N2CCC(=O)CC2)n1.NC1CC1>>CCCc1noc(N2CCC(NC3CC3)CC2)n1",
        "output": "236"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C(=O)N1CCNCC1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl.O=Cc1cccc(C(=O)O)c1.On1nnc2ccccc21>>CC(C)C(=O)N1CCN(C(=O)c2cccc(C=O)c2)CC1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(COc2ncc(-c3ccc(C(=O)O)cc3)cn2)CC1.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.OC1CCNC1>>CC(C)(C)OC(=O)N1CCC(COc2ncc(-c3ccc(C(=O)N4CCC(O)C4)cc3)cn2)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CCSCc1cccc2c(C(CCOS(C)(=O)=O)c3ccc(Cl)cc3C)c[nH]c12.CN(C)C=O.O.[C-]#N.[K+]>>CCSCc1cccc2c(C(CCC#N)c3ccc(Cl)cc3C)c[nH]c12",
        "output": "705"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCCNCC1.CN1CCOCC1.F[P-](F)(F)(F)(F)F.N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)O)cc4)cn23)cc1.O>>CN1CCCN(C(=O)c2ccc(-c3ccc4ncc(-c5ccc(C#N)cc5)n4c3)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCOC(=O)CC[C@H](CO)NC(=O)OC(C)(C)C.CCOC(C)=O.CS(C)=O.Cl.O>>CCOC(=O)CC[C@H](C=O)NC(=O)OC(C)(C)C",
        "output": "142"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(Cn2ncc3c4c(cnc32)CC(NC(=O)OC(C)(C)C)CC4)cc1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(Cn2ncc3c4c(cnc32)CC(N)CC4)cc1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.Cc1nccn1-c1nc(-c2ccc(Cl)cc2)c(CCC(N)=O)o1.O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+]>>Cc1nccn1-c1nc(-c2ccc(Cl)cc2)c(CCC#N)o1",
        "output": "172"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc2[nH]c(-c3ccccc3)c(CCC(=O)O)c2c1.Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)O)c2cc(Cl)ccc21.FC1(Cc2ccccc2)CCNCC1>>Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(F)(Cc3ccccc3)CC2)c2cc(Cl)ccc21",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C1(N)Cc2cc(F)c(F)cc2C1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cccc(C(=O)O)c1I.F[P-](F)(F)(F)(F)F>>CCOC(=O)C1(NC(=O)c2cccc(C)c2I)Cc2cc(F)c(F)cc2C1",
        "output": "709"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.CSc1ccc(C(=O)O)c(O)c1.O=S(Cl)Cl>>COC(=O)c1ccc(SC)cc1O",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COC(=O)/C=C/c1ccccc1N.COc1nc(OC)nc([N+]2(C)CCOCC2)n1.O.O=C(O)c1ccccc1Oc1ccccc1.[Cl-]>>COC(=O)/C=C/c1ccccc1NC(=O)c1ccccc1Oc1ccccc1",
        "output": "50"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.O=C([O-])O.OCc1cc(CO)cc(OCc2ccccc2)c1.[Na+]>>CC(C)(C)[Si](OCc1cc(CO)cc(OCc2ccccc2)c1)(c1ccccc1)c1ccccc1",
        "output": "602"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CO.CS(=O)(=O)Cl.Cc1cc2c(c3ccc(=O)[nH]c13)OC(CO)C2.ClC(Cl)Cl.c1ccncc1>>Cc1cc2c(c3ccc(=O)[nH]c13)OC(COS(C)(=O)=O)C2",
        "output": "0"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cn1c(Nc2cc(C(C)(C)C)on2)nc2cc(Nc3ccnc(Cl)n3)ccc21.Nc1cccc(S(=O)(=O)N2CCOCC2)c1>>Cn1c(Nc2cc(C(C)(C)C)on2)nc2cc(Nc3ccnc(Nc4cccc(S(=O)(=O)N5CCOCC5)c4)n3)ccc21",
        "output": "808"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4scnc4c3)cc(S(C)(=O)=O)c2)c1CCC(=O)OCC.[Na+].[OH-]>>CS(=O)(=O)c1cc(OCCCCCCc2cccc(OCCCC(=O)O)c2CCC(=O)O)cc(-c2ccc3scnc3c2)c1",
        "output": "255"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)c2cc(Br)cc(C(F)(F)F)c2)CC1.CCOC(C)=O.ClCCl.O=C(O)C(F)(F)F>>O=C(c1cc(Br)cc(C(F)(F)F)c1)C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCCCCCCCc1nnn(C(CCCCC)C(=O)OCC)n1.CCCCCCCCCCc1nnn(C(C(=O)OCC)c2ccccc2)n1>>CCCCCCCCCCCCc1nnn(C(CCCCC)C(=O)O)n1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COC(=O)c1ccc(C(=O)OCc2ccccc2)cc1Nc1cccc2ccc(O[Si](C)(C)C(C)(C)C)cc12>>COC(=O)c1ccc(C(=O)OCc2ccccc2)cc1Nc1cccc2ccc(O)cc12",
        "output": "754"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OB(c2ccc(C3(C(=O)NS(C)(=O)=O)CC3)cc2)OC1(C)C.Cc1noc(-c2ccc(Br)cc2)c1C(O)c1cn(Cc2cccc(C(F)(F)F)c2)nn1>>Cc1noc(-c2ccc(-c3ccc(C4(C(=O)NS(C)(=O)=O)CC4)cc3)cc2)c1C(O)c1cn(Cc2cccc(C(F)(F)F)c2)nn1",
        "output": "933"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.C=Cc1ccc(F)c(Br)c1.COCCOC.ClCCl.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>C=Cc1ccc(F)c(N2CCOCC2)c1",
        "output": "294"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.COc1nc(-c2c(C)ccc3[nH]nc(C)c23)nc2c1CN(c1cc(C(C)C)ccc1C)CC2.Cl.ClCCl.O=C([O-])O.[Na+]>>Cc1ccc(C(C)C)cc1N1CCc2nc(-c3c(C)ccc4[nH]nc(C)c34)nc(O)c2C1",
        "output": "408"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)Cc1cc(C)c(C(=O)c2ccc(Cl)n2C)n1C.[Na+].[OH-]>>Cc1cc(CC(=O)O)n(C)c1C(=O)c1ccc(Cl)n1C",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.Nc1ccc(F)c(Cl)c1>>CC(=O)Nc1ccc(F)c(Cl)c1",
        "output": "6"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "NN.O.O.O=C(Cc1ccccn1)c1ccnc2ccccc12.OCCOCCO.[Na+].[OH-]>>c1ccc(CCc2ccnc3ccccc23)nc1",
        "output": "92"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(=O)c1cc(O)ccc1O.Fc1ccc(CBr)cc1.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1cc(OCc2ccc(F)cc2)ccc1O",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CN(C)C(=O)[C@H]1C[C@@H]1c1ccc(Br)cc1>>CN(C)C[C@H]1C[C@@H]1c1ccc(Br)cc1",
        "output": "112"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.O=C(N[C@@H](CC1CCCCC1)C(=O)NC1CCCN(S(=O)(=O)c2ccccn2)CC1O)c1cc2ccccc2o1.O=C([O-])O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>O=C(N[C@@H](CC1CCCCC1)C(=O)NC1CCCN(S(=O)(=O)c2ccccn2)CC1=O)c1cc2ccccc2o1",
        "output": "650"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.ClCc1ccc2c(c1)OCO2.N[C@@H](Cc1ccc2ccccc2c1)C(=O)O.O=C([O-])[O-].[K+].[K+].c1cn(-c2ccc(OC3CCCNC3)nn2)cn1>>c1cn(-c2ccc(OC3CCCN(Cc4ccc5c(c4)OCO5)C3)nn2)cn1",
        "output": "156"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)O)ccn3)CC1)C(=O)N2.F[B-](F)(F)F.O=C1CC2CNc3cccc(c32)N1>>COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)N4CC5CC(=O)Nc6cccc4c65)ccn3)CC1)C(=O)N2",
        "output": "873"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CCC1C(=O)NC1CCOCc1ccccc1.[Pd]>>CCC1C(=O)NC1CCO",
        "output": "178"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc(F)c(COc2nsc(NC(=O)Oc3ccccc3)c2C(N)=O)cc1F.NCCCCN1CCCC(O)C1>>Cc1cc(F)c(COc2nsc(NC(=O)NCCCCN3CCCC(O)C3)c2C(N)=O)cc1F",
        "output": "488"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.NCc1cccc(Oc2ccc3c(c2)OCO3)c1.Nc1ncccc1C(=O)O.O=C([O-])O.On1nnc2ccccc21.[Na+]>>Nc1ncccc1C(=O)NCc1cccc(Oc2ccc3c(c2)OCO3)c1",
        "output": "790"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cl.Cl.Cl[Sn]Cl.Nc1ccc(F)cc1Br.O=N[O-].[Na+]>>NNc1ccc(F)cc1Br",
        "output": "109"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.Cc1cnc(N[C@@H]2CC[C@H](N)CC2)nc1N(C)C.ClCCl.O=C(Cl)c1cccnc1Cl>>Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3cccnc3Cl)CC2)nc1N(C)C",
        "output": "353"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOCC.COc1cc(N)ccc1Cl.Cl.Clc1ccnc2ccc(SC3CCOCC3)cc12>>COc1cc(Nc2ccnc3ccc(SC4CCOCC4)cc23)ccc1Cl",
        "output": "115"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc2cc(Nc3cc(C)[nH]n3)nc(Cl)c2cc1OC.OB(O)c1ccccc1F>>COc1cc2cc(Nc3cc(C)[nH]n3)nc(-c3ccccc3F)c2cc1OC",
        "output": "865"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)C(Cc1ccc2c(c1)CCN2C(=O)c1ccncc1)NC1=C(Cl)C(=O)C12CCCCC2.O=C(O)C(Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)cncc1Cl)NC1=CC(=O)C12CCCCC2>>O=C(O)C(Cc1ccc2c(c1)CCN2C(=O)c1ccncc1)NC1=C(Cl)C(=O)C12CCCCC2",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=O.COc1ccc(N(CCCl)CCCl)cc1.Nc1ccc(-n2cccn2)cc1.O.O=C([O-])O.[I-].[K+].[Na+]>>COc1ccc(N2CCN(c3ccc(-n4cccn4)cc3)CC2)cc1",
        "output": "640"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COCCN.O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](c2ccc(Cl)cc2)[C@H](c2ccccc2)C1.c1ccc(-c2ccccc2P(C2CCCCC2)C2CCCCC2)cc1>>COCCNc1ccc([C@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@H]2c2ccccc2)cc1",
        "output": "304"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.FC(F)(F)c1ccc(N2CCNCC2)c2ncccc12.O=C1CCN(c2cccc3cccnc23)CC1.[Na+]>>FC(F)(F)c1ccc(N2CCN(C3CCN(c4cccc5cccnc45)CC3)CC2)c2ncccc12",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.COC(=O)c1ccc(OCc2c(-c3ccc(F)c(F)c3)noc2CO)nc1.C[Al](C)C.NC1CCOCC1>>O=C(NC1CCOCC1)c1ccc(OCc2c(-c3ccc(F)c(F)c3)noc2CO)nc1",
        "output": "862"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1NCCc2c(-c3ccncc3)cccc21.O=C(O)c1cc2ncc(Cl)cn2n1>>CC1c2cccc(-c3ccncc3)c2CCN1C(=O)c1cc2ncc(Cl)cn2n1",
        "output": "952"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1c(C)cccc1OC.CCOCC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>COc1cccc(C)c1CO",
        "output": "311"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C.F[P-](F)(F)(F)(F)F.NN1CCCC1>>COc1cc(C(=O)NN2CCCC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "55"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.COc1ccc(S(=O)(=O)Nc2ccccc2)c2c1C[C@@H](N)CC2.ClCCl>>CCOC(=O)N[C@H]1CCc2c(S(=O)(=O)Nc3ccccc3)ccc(OC)c2C1",
        "output": "94"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)[Si](OCCCCCCCCCCC#CCCCCOC1CCCCO1)(c1ccccc1)c1ccccc1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>OCCCCCCCCCCC#CCCCCOC1CCCCO1",
        "output": "781"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)COC1C(C(=O)O)C1(C)C.OCc1[nH]ccc1Cc1ccc(Cl)cc1>>CC(C)COC1C(C(=O)OCc2[nH]ccc2Cc2ccc(Cl)cc2)C1(C)C",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)CC(Cn2ccc3cc(-c4cnn(C5CCCCO5)c4)ccc32)CN1.CCN(CC)CC.ClCCl.O=C([O-])O.O=S(=O)(Cl)c1ccccc1.[Na+]>>CC1(C)CC(Cn2ccc3cc(-c4cnn(C5CCCCO5)c4)ccc32)CN1S(=O)(=O)c1ccccc1",
        "output": "99"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(CO)(c1cc(Cl)cc(Cl)c1)N1CCC(CO[Si](C)(C)C(C)(C)C)CC1.CI.[H-].[Na+]>>COCC(C)(c1cc(Cl)cc(Cl)c1)N1CCC(CO[Si](C)(C)C(C)(C)C)CC1",
        "output": "140"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClCCl.Nc1cccc(Br)n1.O>>CC(=O)Nc1cccc(Br)n1",
        "output": "332"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCc1cc(-c2ccc(COc3cccnc3)cc2)no1.Fc1cccc(-c2nc3cn[nH]cc-3n2)c1F>>Fc1cccc(-c2nc3cnn(Cc4cc(-c5ccc(COc6cccnc6)cc5)no4)cc-3n2)c1F",
        "output": "997"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CNc1cc(-n2cc(-c3ccc(OC)cc3)c3ccc(-c4cccc(N)c4)cc32)ncn1.O=C=Nc1ccc(Cl)c(C(F)(F)F)c1>>CNc1cc(-n2cc(-c3ccc(OC)cc3)c3ccc(-c4cccc(NC(=O)Nc5ccc(Cl)c(C(F)(F)F)c5)c4)cc32)ncn1",
        "output": "473"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CC(C)(C)c1ccc(O)c(C(=O)O)c1.Cl.ClC(Cl)Cl.S=C=S.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)c1cc(C(C)(C)C)cc(C(=O)O)c1O",
        "output": "31"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN1CCCC1=O.Clc1nc(C2CCCC2)nc2c1CCC2.NC(=O)Cc1ccc(N)cc1.O>>NC(=O)Cc1ccc(Nc2nc(C3CCCC3)nc3c2CCC3)cc1",
        "output": "352"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1cc(-c2cccc(C=O)n2)c(C)[nH]c1=O.OC1CCNCC1>>CCc1cc(-c2cccc(CN3CCC(O)CC3)n2)c(C)[nH]c1=O",
        "output": "829"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COC(=O)C1COCCC1N.Cc1cc(COc2ccc(S(=O)(=O)Cl)cc2)c2ccccc2n1.Cl>>COC(=O)C1COCCC1NS(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1",
        "output": "43"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(-c3cccc5cc[nH]c35)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12.N.O=C(O)C(F)(F)F>>Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cccc6cc[nH]c56)c34)n(-c3ccccc3)c(=O)c12",
        "output": "897"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(O)c1ccccc1-n1nccn1.c1ccc(-c2ccnc(N3CC4CNCC4C3)n2)cc1>>O=C(c1ccccc1-n1nccn1)N1CC2CN(c3nccc(-c4ccccc4)n3)CC2C1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCCCc1ccccc1.COC(=O)c1cc(-c2ccc(OC)cc2)n[nH]c1=O>>COC(=O)c1cc(-c2ccc(OC)cc2)nn(CCCc2ccccc2)c1=O",
        "output": "577"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCI.COc1c(O)ccc(C(=O)Cc2c(Cl)cncc2Cl)c1OCCc1ccccc1.CS(C)=O.O=C([O-])[O-].[K+].[K+]>>CCOc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OCCc2ccccc2)c1OC",
        "output": "198"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCOC(=O)[C@@H]1CC(O[Si](C)(C)C(C)(C)C)C[C@H]1CO.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>CCOC(=O)[C@@H]1CC(O[Si](C)(C)C(C)(C)C)C[C@H]1COS(=O)(=O)c1ccc(C)cc1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)O.CCCSCCCBr.N#Cc1ccc(CCCCNCCO)cc1.O=C([O-])[O-].[K+].[K+]>>CCCSCCCN(CCO)CCCCc1ccc(C#N)cc1",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1n[nH]c2ncccc12.O=C([O-])O.O=S(=O)(O)O.O=[N+]([O-])O.[Na+]>>Cc1n[nH]c2ncc([N+](=O)[O-])cc12",
        "output": "328"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(=C(Br)c2ccc(C(=O)O)cc2)CC1.CN(CCO)C(=O)c1ccc(C(=C2CCN(Cc3cscn3)CC2)c2cccc3cccnc23)cc1.CNCCO>>CN(CCO)C(=O)c1ccc(C(Br)=C2CCN(C(=O)OC(C)(C)C)CC2)cc1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC(=O)OC(C)=O.N#Cc1ccc(Cl)cc1N>>CC(=O)Nc1cc(Cl)ccc1C#N",
        "output": "6"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC1CCCO1)c1nc(Nc2ccc(-c3cnco3)cc2)nc2c1CN(C(=O)OC(C)(C)C)CC2.CO.Cl>>CCN(CC1CCCO1)c1nc(Nc2ccc(-c3cnco3)cc2)nc2c1CNCC2",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C[C@@H]2Cc3c(O)cccc3C[C@@H]21)O[Si](C)(C)C(C)(C)C.O=C(Cl)c1ccccc1.[H-].[Na+]>>CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)C[C@@H]2Cc3c(cccc3OC(=O)c3ccccc3)C[C@@H]21)O[Si](C)(C)C(C)(C)C",
        "output": "482"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)CCCCCCn1c(C2CC2)cc2nc(-c3ccc(C)cc3)c(-c3ccc(C)cc3)nc21.Cl.O.[Na+].[OH-]>>Cc1ccc(-c2nc3cc(C4CC4)n(CCCCCCC(=O)O)c3nc2-c2ccc(C)cc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CC(O)(Br)CCC1CCC(=O)N1>>CC(Br)(CCC1CCC(=O)N1)O[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCOC(C)=O.CN.O=C(O)CC1COc2cc(Br)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2>>CNC(=O)CC1COc2cc(Br)ccc2N1C(=O)c1ccc2c(c1)NC(=O)CO2",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)C(CCc1ccccc1)NC(=O)CN1C(=O)CC(Cc2ccc(C=NN)cc2)C1=O.Cl>>NN=Cc1ccc(CC2CC(=O)N(CC(=O)NC(CCc3ccccc3)C(=O)O)C2=O)cc1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccc(Cl)cc21)=[N+](C)C.CN1CCCC1=O.Cc1ccc(C(=O)O)cc1I.F[P-](F)(F)(F)(F)F.Nc1ccc(OC(F)(F)F)cc1>>Cc1ccc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1I",
        "output": "817"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)NC[C@H]1CN(c2ccc(N)c(F)c2)C(=O)O1.CC(=O)[O-].Cl.O.O=N[O-].[N-]=[N+]=[N-].[Na+].[Na+].[Na+]>>CC(=O)NC[C@H]1CN(c2ccc(N=[N+]=[N-])c(F)c2)C(=O)O1",
        "output": "189"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.Cc1cc(O)ccc1-c1cc(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cc1.ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>Cc1cc(OS(=O)(=O)C(F)(F)F)ccc1-c1cc(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cc1",
        "output": "731"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(CO)C(=O)O.CC1(C(=O)O)CC1.CN(C)S(=O)(=O)c1ccc(C(=O)O)cc1.CN(C)S(=O)(=O)c1cccc(C(=O)O)c1.CNS(=O)(=O)c1ccc(C(=O)O)cc1.CNS(=O)(=O)c1cccc(C(=O)O)c1.CS(=O)(=O)Nc1ccc(C(=O)O)cc1.Cc1ncnc(C)c1C(=O)N1CC2CN(CCC3(c4cccc(F)c4)CCNCC3)CC2C1.NS(=O)(=O)c1cccc(C(=O)O)c1.O=C(O)C1(C(F)(F)F)CC1>>Cc1ncnc(C)c1C(=O)N1CC2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C4(C(F)(F)F)CC4)CC3)CC2C1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.NS(=O)(=O)c1cccc(CCCOCCCCCCCN(Cc2ccccc2)C[C@H](O)c2ccc(O)c(CO)c2)c1.[Pd]>>NS(=O)(=O)c1cccc(CCCOCCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1",
        "output": "84"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)c1ccc(C(N)=O)c2[nH]ccc12.ClCCl.O=C(O)C(F)(F)F>>NC(=O)c1ccc(C(=O)O)c2cc[nH]c12",
        "output": "752"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)N=C=NC(C)C.NCCc1cccc(C(F)(F)F)c1.O=C(O)c1ccc2c(c1)nc(COc1ccccc1)n2Cc1ccc(OC(F)(F)F)cc1>>O=C(NCCc1cccc(C(F)(F)F)c1)c1ccc2c(c1)nc(COc1ccccc1)n2Cc1ccc(OC(F)(F)F)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)O)C(=O)C2.Cn1ccnc1-c1ccccc1Nc1nc(Cl)ncc1Cl.Nc1ccc2c(c1)CCC(NCC(F)(F)F)CC2>>Cn1ccnc1-c1ccccc1Nc1nc(Nc2ccc3c(c2)CCC(NCC(F)(F)F)CC3)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#CCCC(=O)OC.CC(=O)[O-].CC(=O)[O-].CCN(CC)CC.O=[N+]([O-])c1cc(F)cc(Br)c1F.[Cu]I.[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)CCC#Cc1cc(F)cc([N+](=O)[O-])c1F",
        "output": "659"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C1Oc2c(Br)cc(C(=O)O)cc2NC1=O.CCN(C(C)C)C(C)C.CCO.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F>>CNC(=O)c1cc(Br)c2c(c1)NC(=O)C(C(C)C)O2",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc2c(CCI)coc2c1.Cc1cc(N2CCNCC2)c2ncccc2c1>>COc1ccc2c(CCN3CCN(c4cc(C)cc5cccnc45)CC3)coc2c1",
        "output": "184"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.COc1ccc(S(=O)(=O)N2CCN(C(C)c3nc4ccc(C#N)cc4c(=O)n3C)CC2)cc1.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>COc1ccc(S(=O)(=O)N2CCN(C(C)c3nc4ccc(-c5nnn[nH]5)cc4c(=O)n3C)CC2)cc1",
        "output": "390"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccc(C(=O)O)s1.CI.CN(C)C=O.O=C([O-])[O-].[Na+].[Na+]>>COC(=O)c1ccc(C(C)=O)s1",
        "output": "415"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)C(NC(=O)OC(C)(C)C)c1ccn(C)n1.O.[Li+].[OH-]>>Cn1ccc(C(NC(=O)OC(C)(C)C)C(=O)O)n1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CCCCCC(O)c1ccc2ccccc2c1.CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CNc1cccc(NC)n1.ClCCl.c1c[nH]cn1>>C=CCCCCC(O[Si](C)(C)C(C)(C)C)c1ccc2ccccc2c1",
        "output": "193"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(C)=O.O=C(O)c1cc(O)ccc1O.O=[N+]([O-])c1ccc(Cl)cc1.[Na+].[OH-].c1ccccc1>>O=C(O)c1cc(Oc2ccc([N+](=O)[O-])cc2)ccc1O",
        "output": "299"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cc1ccc2c(c1)C(=O)C(=O)N2C(CC1CCCC1)C(=O)O.F[P-](F)(F)(F)(F)F.Nc1ccccn1>>Cc1ccc2c(c1)C(=O)C(=O)N2C(CC1CCCC1)C(=O)Nc1ccccn1",
        "output": "368"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN.CO.O.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>CCNS(=O)(=O)c1ccc([N+](=O)[O-])cc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1ccc(C#N)c(C)c1.[BH4-].[Cl-].[Li+].[Na+]>>Cc1cc(CO)ccc1C#N",
        "output": "444"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC1CC(C)(N)CC(C)O1.N#C[C@@H]1C[C@H](F)CN1C(=O)CCl.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CC1CC(C)(NCC(=O)N2C[C@@H](F)C[C@H]2C#N)CC(C)O1",
        "output": "330"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.NCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21.O.O.O=C(O)c1cncc(Br)c1.On1nnc2ccccc21>>O=C(NCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21)c1cncc(Br)c1",
        "output": "674"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCS(=O)(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2N)c1C.O=S(=O)(Cl)C1CC1.c1ccncc1>>CCS(=O)(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2NS(=O)(=O)C2CC2)c1C",
        "output": "194"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC(NC2CCCCC2)CC1.CC(C)=O.Cc1ccc(S(=O)(=O)Cl)cc1.O=[N+]([O-])c1cccc([N+](=O)[O-])c1CO>>Cc1ccc(S(=O)(=O)OCc2c([N+](=O)[O-])cccc2[N+](=O)[O-])cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCOC(C)=O.ClCCl.Nc1cccc(-n2c(=O)c(Cc3ccccc3)nc3cccnc32)c1.O=C(Cl)c1ccccc1.O=C([O-])O.[Na+]>>O=C(Nc1cccc(-n2c(=O)c(Cc3ccccc3)nc3cccnc32)c1)c1ccccc1",
        "output": "11"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)c1cn(-c2ccc(-c3cccc(S(C)(=O)=O)c3)cc2Cl)c(-c2ccccc2Cl)n1.ClCCl.[H-]>>CS(=O)(=O)c1cccc(-c2ccc(-n3cc(CO)nc3-c3ccccc3Cl)c(Cl)c2)c1",
        "output": "286"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.C[C@H]1CNCCN1C(=O)OC(C)(C)C.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[K+].[K+]>>C[C@H]1CN(c2ccc([N+](=O)[O-])cc2)CCN1C(=O)OC(C)(C)C",
        "output": "26"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1ccc2c(c1)N(Cc1ccccc1)CCC2.C1CCOC1.CC(C)c1ccc(Br)cc1C=O.[Li]CCCC>>CC(C)c1ccc(Br)cc1C(O)c1ccc2c(c1)N(Cc1ccccc1)CCC2",
        "output": "379"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1ccc2c(c1)ncn2C1CCC1.CCO.Cl>>Nc1ccc2c(c1)ncn2C1CCC1",
        "output": "66"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CNCC1COCCO1.Cl.ClCCl.O=C(Cl)OCc1ccccc1>>CN(CC1COCCO1)C(=O)OCc1ccccc1",
        "output": "427"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O.O=C1CCC(CO)CC1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCC1CCC(=O)CC1",
        "output": "193"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CC(C)=O.CS(=O)(=O)Nc1ccc(CCOc2ccc(C=O)cc2)cc1.O.O=C1CSC(=O)N1.[Na+]>>CS(=O)(=O)Nc1ccc(CCOc2ccc(C=C3SC(=O)NC3=O)cc2)cc1",
        "output": "761"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCC(=O)Cl.N[C@H]1CC[C@@H](C(=O)O)C1.[Na+].[OH-]>>CCC(=O)N[C@H]1CC[C@@H](C(=O)O)C1",
        "output": "45"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](OCC1(C=O)CC1)(c1ccccc1)c1ccccc1.CN(C)Cc1c(-c2ccccc2)ccc2c(CCC3CCNCC3)noc12>>CN(C)Cc1c(-c2ccccc2)ccc2c(CCC3CCN(CC4(CO[Si](c5ccccc5)(c5ccccc5)C(C)(C)C)CC4)CC3)noc12",
        "output": "484"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)cc1OCC.Cc1ccc(OCc2ccccc2)cc1C(=O)O.Cl>>CCOc1ccc(C2=NN(C3CCN(C(=O)c4cc(OCc5ccccc5)ccc4C)CC3)C(=O)C2(C)C)cc1OCC",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCNCC.ClCCl.ClCCl.O=C(O)c1ccc(F)c([N+](=O)[O-])c1.O=S(Cl)Cl>>CCN(CC)C(=O)c1ccc(F)c([N+](=O)[O-])c1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Nc1ccc(F)c(C(=O)O)c1.O=S(Cl)Cl>>COC(=O)c1cc(N)ccc1F",
        "output": "33"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COCOc1cccc2c1CC[C@H](C)N2C(C)=O.Cl>>CC(=O)N1c2cccc(O)c2CC[C@@H]1C",
        "output": "755"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1coc(NC(C)=O)n1>>CC(=O)Nc1nc(C(=O)O)co1",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCCl.Nc1ccc2ccccc2c1-c1c(P(=O)(c2ccccc2)c2ccccc2)ccc2ccccc12.O=C(Cl)c1ccccc1.[Cl-].[NH4+].c1ccncc1>>O=C(Nc1ccc2ccccc2c1-c1c(P(=O)(c2ccccc2)c2ccccc2)ccc2ccccc12)c1ccccc1",
        "output": "11"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.COC(=O)c1cc(C)c(-c2ccc(OC)c(-c3ccc(S(N)(=O)=O)cc3)c2)n1C.[Na+].[OH-]>>COc1ccc(-c2c(C)cc(C(=O)O)n2C)cc1-c1ccc(S(N)(=O)=O)cc1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrBr.CC(=O)O.O=C(O)c1cc(I)ccc1O>>O=C(O)c1cc(I)cc(Br)c1O",
        "output": "98"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)CC(=O)O.Cl.Cl.Cl.N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1>>CC(C)CC(=O)N[C@@H]1CC[C@@H](CCN2CCN(c3nccc4c3CCO4)CC2)CC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1cc(-c2cccc(-c3ccc(F)c4ccccc34)n2)c(C)[nH]1.O.OC1CCN(Cc2ccccc2)CC1.[H-].[Na+]>>Cc1cc(-c2cccc(-c3ccc(OC4CCN(Cc5ccccc5)CC4)c4ccccc34)n2)c(C)[nH]1",
        "output": "485"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cccc(CNC(=O)c2ccc(Cl)nc2)c1.Cc1ccc(NC(=O)c2ccoc2)cc1B1OC(C)(C)C(C)(C)O1>>COc1cccc(CNC(=O)c2ccc(-c3cc(NC(=O)c4ccoc4)ccc3C)nc2)c1",
        "output": "955"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cl.ClC(Cl)Cl.O=C(O)[C@@H]1CCN(C(=O)OCc2ccccc2)C1>>COC(=O)[C@@H]1CCN(C(=O)OCc2ccccc2)C1",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C(=O)OC(C)(C)C)c1cc(Cl)ccc1[N+](=O)[O-].CN(C)C=O.Oc1ccccc1N1CCOCC1.[H-].[Na+]>>CN(C(=O)OC(C)(C)C)c1cc(Oc2ccccc2N2CCOCC2)ccc1[N+](=O)[O-]",
        "output": "299"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1(C)C.COCCOc1ccn2c(-c3ccc4c(F)ccc(Br)c4n3)cnc2c1.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COCCOc1ccn2c(-c3ccc4c(F)ccc(N5CCN(C(=O)OC(C)(C)C)C(C)(C)C5)c4n3)cnc2c1",
        "output": "597"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.OCCCCCCCl.c1ccncc1>>Cc1ccc(S(=O)(=O)OCCCCCCCl)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COC(=O)c1nc(-c2ccc(Cl)c(OC)c2F)cc(NC(C)=O)c1OCc1ccccc1.[OH-].[OH-].[Pd+2]>>COC(=O)c1nc(-c2ccc(Cl)c(OC)c2F)cc(NC(C)=O)c1O",
        "output": "264"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.ClCCl.Nc1ccc(Oc2ccc(CO)cn2)cc1.O=[Mn]=O>>Nc1ccc(Oc2ccc(C=O)cn2)cc1",
        "output": "520"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2ccc(OC)c(F)c2)cc1>>COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2ccc(O)c(F)c2)cc1",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(Cl)Cl.COc1nccc2c(-c3cc(S(C)(=O)=O)ccc3N)cn(C)c12.O=CC1CCCC1>>COc1nccc2c(-c3cc(S(C)(=O)=O)ccc3NCC3CCCC3)cn(C)c12",
        "output": "336"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(CCCc1ccccc1)Oc1cc(O)c2c(c1)N1CCCCC1CC2CCC#N.CCOC(C)=O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(CCCc1ccccc1)Oc1cc(O)c2c(c1)N1CCCCC1CC2CCCN",
        "output": "246"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "N#CC1CCN(C(=O)N2CC(C(=O)O)CC(c3ccc(C(F)(F)F)cc3)C2)CC1.NC(CC1(CO)CC1)=NO>>N#CC1CCN(C(=O)N2CC(c3ccc(C(F)(F)F)cc3)CC(c3nc(CC4(CO)CC4)no3)C2)CC1",
        "output": "728"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)[C@H](C)NCCN.Cl.Cl.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CCOC(=O)[C@H](C)NCCNS(=O)(=O)c1ccccc1[N+](=O)[O-]",
        "output": "43"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.O=C([O-])[O-].O=S(=O)(O)O.OCC(O)CBr.[K+].[K+]>>CC1(C)OCC(CBr)O1",
        "output": "265"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CNc1ccnc(N)c1.CSc1ccc(C(=O)CBr)cc1>>CNc1ccn2cc(-c3ccc(SC)cc3)nc2c1",
        "output": "508"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.COC(=O)C[C@@H](C)O.O.c1c[nH]cn1>>COC(=O)C[C@@H](C)O[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CNC.COc1cccc(OC)c1C(=O)Cl>>COc1cccc(OC)c1C(=O)N(C)C",
        "output": "201"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCn1ncc(C(=O)OCC)n1.CCO.O.[K+].[OH-]>>CCCCn1ncc(C(=O)O)n1",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCc1cnc2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CCC2=CC(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>CCCCc1cnc2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CCC2=CC(=O)O",
        "output": "158"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C(=C[C@@H]1CC[C@@H](Nc2ncnc3[nH]ncc23)CC1)CCc1ccccc1.CCO.[Pd]>>c1ccc(CCCC[C@@H]2CC[C@@H](Nc3ncnc4[nH]ncc34)CC2)cc1",
        "output": "143"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOCC.CO.Cc1cccc(C(=O)Cl)c1[N+](=O)[O-].ClCCl>>COC(=O)c1cccc(C)c1[N+](=O)[O-]",
        "output": "51"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)Oc1ccccc1C(=O)Oc1cccc(C=O)c1.CO.[BH4-].[Na+]>>CC(=O)Oc1ccccc1C(=O)Oc1cccc(CO)c1",
        "output": "356"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCN.COC(=O)C(c1ccc(F)c(F)c1)c1ccccn1>>CCCCCCNC(=O)C(c1ccc(F)c(F)c1)c1ccccn1",
        "output": "392"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CS(=O)(=O)Cl.Nc1ccc([N+](=O)[O-])cc1.c1ccncc1>>CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1",
        "output": "194"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(=O)C[C@@H]1CCc2cc(OCCCN(C)c3nc(Cl)c(C#N)cc3F)ccc21.COc1ccc(B(O)O)cc1.Cc1ccccc1.ClCCl.Cl[Pd]Cl.O.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)C[C@@H]1CCc2cc(OCCCN(C)c3nc(-c4ccc(OC)cc4)c(C#N)cc3F)ccc21",
        "output": "865"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1cc2c(Oc3ccc4[nH]cc(C)c4c3)ncnc2cc1O.Cl.ClCCN1CCOCC1.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(Oc3ccc4[nH]cc(C)c4c3)ncnc2cc1OCCN1CCOCC1",
        "output": "74"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.O=C(Cc1ccccc1)c1ccc(O)cc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1ccc(C(=O)Cc2ccccc2)cc1",
        "output": "746"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.COC(=O)Cc1ccnc(Cl)c1.Cc1ccccc1.ClCCl.Cl[Pd]Cl.N#N.O=P([O-])([O-])[O-].OB(O)c1ccc(OC(F)(F)F)cc1.[Fe+2].[K+].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COC(=O)Cc1ccnc(-c2ccc(OC(F)(F)F)cc2)c1",
        "output": "865"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CNCc1cccnc1.COc1cc(-c2ccccc2Cl)c(Cl)cc1C(=O)N1Cc2ccc(C(=O)O)n2Cc2ccccc21.Cl.ClC(Cl)Cl.On1nnc2ccccc21>>COc1cc(-c2ccccc2Cl)c(Cl)cc1C(=O)N1Cc2ccc(C(=O)N(C)Cc3cccnc3)n2Cc2ccccc21",
        "output": "605"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O.O=C1C[C@@H](O)CN1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)O[C@H]1CNC(=O)C1",
        "output": "193"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(Nc2cnc(C3CC3)c(C)c2)c(C(=O)OC(C)(C)C)c1.O=C(O)C(F)(F)F>>Cc1ccc(Nc2cnc(C3CC3)c(C)c2)c(C(=O)O)c1",
        "output": "752"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)CBr.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.II.O.O=C([O-])[O-].O=Cc1ccc(O)cc1.[K+].[K+]>>COC(=O)COc1ccc(C=O)cc1",
        "output": "557"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CN(C)c1ccc(C(=N)N)cc1)n2C)c1ccccc1.Cl.[Na+].[OH-]>>CN(Cc1nc2cc(C(=O)N(CCC(=O)O)c3ccccc3)ccc2n1C)c1ccc(C(=N)N)cc1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)NC(=O)Cn1c(-c2cccc(Cl)c2)nc2ccc(Br)cc2c1=O.CC(C)(C)OC(=O)N1CCCNCC1.Cc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)NC(=O)Cn1c(-c2cccc(Cl)c2)nc2ccc(N3CCCN(C(=O)OC(C)(C)C)CC3)cc2c1=O",
        "output": "294"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=S(=O)(O)O.O=[N+]([O-])O.O=[N+]([O-])c1cccc(S(F)(F)(F)(F)F)c1>>O=[N+]([O-])c1cc([N+](=O)[O-])cc(S(F)(F)(F)(F)F)c1",
        "output": "21"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(CC(=O)O)s1.CCN(CC)CC.CN(C)C=O.CN(C)c1ccccc1.C[Si](C)(C)Cl.Cc1ccc(SCC2=C(C(=O)O)N3C(=O)[C@@H](N)[C@H]3SC2)n[n+]1[O-].ClCCl.O=C(Cl)C(=O)Cl>>Cc1ccc(SCC2=C(C(=O)O)N3C(=O)[C@@H](NC(=O)Cc4ccc(CNC(=O)OC(C)(C)C)s4)[C@H]3SC2)n[n+]1[O-]",
        "output": "133"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)C(=O)c1ccc(OCCCCc2ccncc2)cc1.O.[Na+].[OH-]>>O=C(O)C(=O)c1ccc(OCCCCc2ccncc2)cc1",
        "output": "506"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCCC(=O)O.CC#N.CC(C)[C@H](N)C(=O)N[C@@H](Cc1cccc(O[Si](C)(C)C(C)(C)C)c1)C(=O)N1CCC[C@@H](C(=O)OCC(Cl)(Cl)Cl)N1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.C[NH3+].F[P-](F)(F)(F)(F)F.F[P-](F)(F)(F)(F)F>>C=CCCC(=O)N[C@H](C(=O)N[C@@H](Cc1cccc(O[Si](C)(C)C(C)(C)C)c1)C(=O)N1CCC[C@@H](C(=O)OCC(Cl)(Cl)Cl)N1)C(C)C",
        "output": "133"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Br.C1CCOC1.CCN(C(C)C)C(C)C.CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.NCCCBr.O>>CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)NCCCBr",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.O=C1c2ccccc2C(=O)N1CC(F)(F)CO.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>O=C1c2ccccc2C(=O)N1CC(F)(F)COS(=O)(=O)C(F)(F)F",
        "output": "582"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(C(=O)/C=C/c2c[nH]c3ccccc23)cc(OC)c1OC.O=S(=O)(Cl)c1ccccc1>>COc1cc(C(=O)/C=C/c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)cc(OC)c1OC",
        "output": "648"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cc(NS(=O)(=O)c2ccc(Cl)cc2)ccc1Oc1cncc(Cl)c1.CO.O.[Li+].[OH-]>>O=C(O)c1cc(NS(=O)(=O)c2ccc(Cl)cc2)ccc1Oc1cncc(Cl)c1",
        "output": "5"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)COC(=O)Cl.CC(CC(=O)O)NC(=O)OCc1ccccc1.CN1CCOCC1.CNOC.Cl.Cl.ClCCl>>CON(C)C(=O)CC(C)NC(=O)OCc1ccccc1",
        "output": "54"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC1CCc2c1ncc(N)c2N1CCC[C@H](NC(=O)OC(C)(C)C)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CS(=O)(=O)c1cc(F)c(-c2nc(C(=O)O)ccc2F)c(F)c1.F[P-](F)(F)(F)(F)F>>CC(=O)OC1CCc2c1ncc(NC(=O)c1ccc(F)c(-c3c(F)cc(S(C)(=O)=O)cc3F)n1)c2N1CCC[C@H](NC(=O)OC(C)(C)C)C1",
        "output": "776"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CSCCNc1ccc([N+](=O)[O-])cc1.[Cl-].[NH4+].[Zn]>>CSCCNc1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1c[nH]c2cc(Cl)c(-c3ccc(O[C@H]4CCCC[C@@H]4O)cc3)cc12.[Na+].[OH-]>>O=C(O)c1c[nH]c2cc(Cl)c(-c3ccc(O[C@H]4CCCC[C@@H]4O)cc3)cc12",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(O)(CC)COc1ccc(C(CC)(CC)c2cc3ccc(O)cc3s2)cc1C.CCN(CC)CC.CCOCC.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CCC(O)(CC)COc1ccc(C(CC)(CC)c2cc3ccc(OS(=O)(=O)C(F)(F)F)cc3s2)cc1C",
        "output": "731"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCOC(=O)Nc1cc(C[C@H]2C(=O)N(C(=O)N[C@H](C)c3ccccc3)[C@@H]2C(=O)OCc2ccccc2)ccn1.CCOC(C)=O.CO.[Pd]>>CCCCCCOC(=O)Nc1cc(C[C@H]2C(=O)N(C(=O)N[C@H](C)c3ccccc3)[C@@H]2C(=O)O)ccn1",
        "output": "186"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2cnco2)c2ccccc12.O=C(O)C(F)(F)F>>Nc1ccc(-c2cnco2)c2ccccc12",
        "output": "782"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)[C@H](CNC(=O)c1ccc(CCC(=O)NC(=N)N)s1)NC(=O)OCc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>N=C(N)NC(=O)CCc1ccc(C(=O)NC[C@H](NC(=O)OCc2ccccc2)C(=O)O)s1",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOCC.Cc1ccc(Cl)cc1C(=O)O.O=S(Cl)Cl>>CCOC(=O)c1cc(Cl)ccc1C",
        "output": "47"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C[C@H](CO)[C@@H](c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1.N#Cc1ccc(N=C=O)cc1>>C[C@H](COC(=O)Nc1ccc(C#N)cc1)[C@@H](c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1",
        "output": "34"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CN.CC(C)(C)OC(=O)N[C@H](CCS(C)(=O)=O)C(=O)O>>CC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CCS(C)(=O)=O)NC(=O)OC(C)(C)C",
        "output": "133"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CNOC.Cl.O=C(O)Cc1c(C(=O)c2ccccc2)[nH]c2cc(Cl)ccc12>>CON(C)C(=O)Cc1c(C(=O)c2ccccc2)[nH]c2cc(Cl)ccc12",
        "output": "54"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)[C@H](CC(C)C)Nc1onc(C)c1-c1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)cc1.Cl.[Li+].[OH-]>>Cc1noc(N[C@@H](CC(C)C)C(=O)O)c1-c1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(Br)ccc1CO.O=S(Cl)Cl>>Cc1cc(Br)ccc1CCl",
        "output": "81"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C[Si](C)(C)CCOCn1ncc([N+](=O)[O-])c1CO.ClC(Cl)Cl.[Mn+4].[O-2].[O-2]>>C[Si](C)(C)CCOCn1ncc([N+](=O)[O-])c1C=O",
        "output": "573"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CNc1nc(-c2cc(F)c(C#N)c(OC)c2)cc(N2CCOC[C@H]2C(C)C)n1.NN.O>>CNc1nc(-c2cc(OC)c3c(N)n[nH]c3c2)cc(N2CCOC[C@H]2C(C)C)n1",
        "output": "945"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)N=C=NC(C)C.CCC(C(=O)O)n1cc(OC)c(-c2cc(Cl)ccc2C#N)cc1=O.CCOC(=O)c1ccc(N)cc1.CN(C)C=O.COC(C)(C)C.O>>CCOC(=O)c1ccc(NC(=O)C(CC)n2cc(OC)c(-c3cc(Cl)ccc3C#N)cc2=O)cc1",
        "output": "710"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCCCCc1c(C(C)C)nc(C(C)C)c(CO)c1-c1ccc(F)cc1.ClCCl.c1c[nH]cn1>>CCCCCc1c(C(C)C)nc(C(C)C)c(CO[Si](C)(C)C(C)(C)C)c1-c1ccc(F)cc1",
        "output": "193"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOCC.CO.O.O=C(O)c1ccc2cc(Cl)ccc2c1.O=S(=O)(O)O>>COC(=O)c1ccc2cc(Cl)ccc2c1",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCC(C)N1CCNCC1.Cl.Cl.O=Cc1ccc(C(=O)O)cc1>>CCCCCCC(C)N1CCN(C(=O)c2ccc(C=O)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.CCO.Nc1ccc(CCCC(=O)O)cc1.[Br-].[K+]>>CC(=O)Nc1ccc(CCCC(=O)O)cc1",
        "output": "6"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(C(C)CNC(=O)OC(C)(C)C)cc1.O=C1CCC(=O)N1Cl>>COc1cc(Cl)c2[nH]c(=O)c3sccc3c2c1-c1ccc(C(C)CNC(=O)OC(C)(C)C)cc1",
        "output": "743"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCC2=NCCCN2CC1.C1CCOC1.CC(C)(C)[Si](C)(C)Cl.COC(=O)c1cc2ccc(O)cc2[nH]1>>COC(=O)c1cc2ccc(O[Si](C)(C)C(C)(C)C)cc2[nH]1",
        "output": "746"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCCC1COc2ccccc2O1.CCN(CC)CC.CN(C)C=O.O.O=C1COC2(CCNCC2)CN1>>O=C1COC2(CCN(CCC3COc4ccccc4O3)CC2)CN1",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)C(C)(C)C(CC(C)C)c1ccc2c(cnn2-c2ccc(F)cc2)c1.CS(C)=O.[Na+].[OH-]>>CC(C)CC(c1ccc2c(cnn2-c2ccc(F)cc2)c1)C(C)(C)C(=O)O",
        "output": "361"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(N)COP(=O)(OC(C)(C)C)OC(C)(C)C.CC(C)c1ccc2c(Nc3cc(C(=O)O)ccc3Sc3ccc(NC(=O)OC(C)(C)C)cc3)ncnc2n1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CS(C)=O.F[B-](F)(F)F>>CC(C)c1ccc2c(Nc3cc(C(=O)NC(C)(C)COP(=O)(OC(C)(C)C)OC(C)(C)C)ccc3Sc3ccc(NC(=O)OC(C)(C)C)cc3)ncnc2n1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(C)(c1ccc(N)cc1)c1ccc(O)cc1.O=C1C=CC(=O)O1>>CC(C)(c1ccc(O)cc1)c1ccc(N2C(=O)C=CC2=O)cc1",
        "output": "410"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCc1n[nH]c(=O)c2cc(OC)ccc12.O=P(Cl)(Cl)Cl>>CCCCc1nnc(Cl)c2cc(OC)ccc12",
        "output": "537"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1ccc(=O)[nH]c1C.N.O=P(Cl)(Cl)Cl>>CCOC(=O)c1ccc(Cl)nc1C",
        "output": "100"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2F)cc1N.Cc1ccc(-c2cccc(C(=O)CC(=O)OC(C)(C)C)c2)cn1>>Cc1ccc(-c2cccc(C(=O)CC(=O)Nc3cc(-c4ccccc4F)ccc3NC(=O)OC(C)(C)C)c2)cn1",
        "output": "929"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.NCCc1ccccc1.O=C(Cl)c1ccc(C(F)(F)F)cc1>>O=C(NCCc1ccccc1)c1ccc(C(F)(F)F)cc1",
        "output": "271"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCNCC1.CN(C)C=O.O.O=[N+]([O-])c1cc(Cl)ccc1Cl>>O=[N+]([O-])c1cc(Cl)ccc1N1CCCCC1",
        "output": "105"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)N1CCN(c2cccnc2)CC1.O=C1CCC(=O)N1Br>>CC(=O)N1CCN(c2ccc(Br)nc2)CC1",
        "output": "779"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.COC(=O)CC(C)c1nc2c3cccnc3ccc2n1C.O.O.[Li+].[OH-]>>CC(CC(=O)O)c1nc2c3cccnc3ccc2n1C",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CCOCC.O=C1NC(=O)c2c(CCCBr)cccc21>>O=C1NC(=O)c2c(CCCN3CCOCC3)cccc21",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1c(-c2noc(-c3cnc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(CC(=O)OC(C)(C)C)C2.ClCCl.O=C(O)C(F)(F)F>>Cc1c(-c2noc(-c3cnc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(CC(=O)O)C2",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)C[AlH]CC(C)C.CO.COC(=O)c1cc2cnc(SC)nc2n1C1CCCC1.ClCCl>>CSc1ncc2cc(CO)n(C3CCCC3)c2n1",
        "output": "546"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN(C)C=O.COC(=O)Cc1ccc(O)cc1.CS(=O)(=O)Cl.Cc1noc(C)c1CCO.Cc1noc(C)c1CCOS(C)(=O)=O.ClCCl.O.[H-].[Na+]>>COC(=O)Cc1ccc(OCCc2c(C)noc2C)cc1",
        "output": "702"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(CC)CC.Cl.O=C(O)Cc1cccc([N+](=O)[O-])c1.O=C(n1ccnc1)n1ccnc1.OC1CNC1>>O=C(Cc1cccc([N+](=O)[O-])c1)N1CC(O)C1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCS(=O)(=O)Nc1ccc(N2CCC(=O)CC2)cc1.NC[C@H](O)COc1cccc2[nH]c(=O)[nH]c12>>CCCCS(=O)(=O)Nc1ccc(N2CCC(NC[C@H](O)COc3cccc4[nH]c(=O)[nH]c34)CC2)cc1",
        "output": "236"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.COc1ccc(-c2ccc(C(=O)O)cc2)cc1.C[C@H](Cl)C[C@H](C)Oc1ccc(O)cc1.ClCCl.c1cc(N2CCCC2)ccn1>>COc1ccc(-c2ccc(C(=O)Oc3ccc(O[C@@H](C)C[C@H](C)Cl)cc3)cc2)cc1",
        "output": "355"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)NC(C)C.Clc1cc2cccc(-c3ccccc3)c2c(Cl)n1.II.[Li]CCCC>>Clc1nc(Cl)c2c(-c3ccccc3)cccc2c1I",
        "output": "850"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC1(C)OB(c2ccc(C(=O)Cl)cc2)OC1(C)C.COc1ccnc(N)c1>>COc1ccnc(NC(=O)c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)c1",
        "output": "463"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Cc1cc(N)cc(C)n1.O=C=NCCCl>>Cc1cc(NC(=O)NCCCl)cc(C)n1",
        "output": "176"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4ccc(N5CCN(C(=O)OC(C)(C)C)CC5)cc4F)cnc32)cc1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4ccc(N5CCNCC5)cc4F)cnc32)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.C[C@H]1CCC[C@@](O)(CN)C1.Cl.O=C(O)c1cn(CC2CCOC2)c2nccc(Cl)c12.On1nnc2ccccc21>>C[C@H]1CCC[C@@](O)(CNC(=O)c2cn(CC3CCOC3)c3nccc(Cl)c23)C1",
        "output": "674"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCC1CC1.Oc1ccccc1Br>>Brc1ccccc1OCC1CC1",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)CCCc1ccc(C(=O)Cc2ccccc2)cc1.[BH4-].[Na+]>>COC(=O)CCCc1ccc(C(O)Cc2ccccc2)cc1",
        "output": "24"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CN2CCC(CC2)N1.CCN(CC)CC.CO.COC(=O)c1cc(Cl)ncc1[N+](=O)[O-]>>COC(=O)c1cc(N2CCN3CCC2CC3)ncc1[N+](=O)[O-]",
        "output": "220"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CN1CCCC1CCNc1ccc([N+](=O)[O-])cc1[N+](=O)[O-].Cl.O>>CN1CCCC1CCNc1ccc([N+](=O)[O-])cc1N",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)Cn1c(C)c(Cc2ccccc2S(=O)(=O)N2CCCC2)c(C)c1C#N.CO.Cl.O.[Li+].[OH-]>>Cc1c(Cc2ccccc2S(=O)(=O)N2CCCC2)c(C)n(CC(=O)O)c1C#N",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCCCCCCc1cc(C(C(=O)O)c2ccccc2)no1.CCCCCCCCCCCCc1cc(C(C(=O)O)c2ccccc2)on1.Nc1ccc(F)cc1F>>CCCCCCCCCCCCc1cc(C(C(=O)Nc2ccc(F)cc2F)c2ccccc2)on1",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)c1ccc(O)cc1.N#Cc1ccc(N(CCO)CC(F)(F)F)cc1C(F)(F)F>>CC(=O)c1ccc(OCCN(CC(F)(F)F)c2ccc(C#N)c(C(F)(F)F)c2)cc1",
        "output": "478"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(Br)cc1S(=O)(=O)NC(C)(C)C.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>CC(C)(C)NS(=O)(=O)c1cc(Br)ccc1CBr",
        "output": "29"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](Oc1cccc(C(=O)c2n[nH]c3ccccc23)c1)(c1ccccc1)c1ccccc1.CC(C)CI.CCCCCC.CCOC(C)=O.CN(C)C=O.[H-].[Na+]>>CC(C)Cn1nc(C(=O)c2cccc(O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)c2)c2ccccc21",
        "output": "346"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.O=C(O)[C@@H]1CC[C@@H](C(F)(F)F)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OC[C@@H]1CC[C@@H](C(F)(F)F)CC1",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)CC(=O)c1cccc(O)c1.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c(Cl)c1.[K+].[K+]>>CC(C)(C)CC(=O)c1cccc(Oc2ccc([N+](=O)[O-])cc2Cl)c1",
        "output": "564"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.O=C([O-])O.[H-].[Na+].[Na+].c1cncc(-c2cc3ccccc3[nH]2)c1>>Cn1c(-c2cccnc2)cc2ccccc21",
        "output": "191"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CC[C@@H](N)C(=O)O.CO.Cl>>C=CC[C@@H](N)C(=O)OC",
        "output": "195"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.O.O=C(N1CCC(O)C1)C1(c2ccc(Cl)cc2)CC1>>O=C1CCN(C(=O)C2(c3ccc(Cl)cc3)CC2)C1",
        "output": "650"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COc1cc(OC)cc(C(C)(C)C=O)c1.[BH4-].[Na+]>>COc1cc(OC)cc(C(C)(C)CO)c1",
        "output": "223"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccccc1N1CCNCC1.Cl.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>COc1ccccc1N1CCN(C(=O)C(F)(F)F)CC1",
        "output": "397"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.COc1ccc(COC[C@H](C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](C)CCCO)cc1.ClCCl.c1c[nH]cn1>>COc1ccc(COC[C@H](C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](C)CCCO[Si](C)(C)C(C)(C)C)cc1",
        "output": "193"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cnn(Cc2nc(-c3cccc(C(F)(F)F)c3)cs2)c1.[Na+].[OH-]>>O=C(O)c1cnn(Cc2nc(-c3cccc(C(F)(F)F)c3)cs2)c1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CC(C(=O)O)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CNOC.F[P-](F)(F)(F)(F)F.[Cl-].[NH4+]>>CON(C)C(=O)C1CN(C(=O)OC(C)(C)C)C1",
        "output": "54"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClC(Cl)Cl.Nc1ccccc1S(N)(=O)=O.O=C1CCC(=O)N1Cl>>Nc1ccc(Cl)cc1S(N)(=O)=O",
        "output": "121"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-c2nc3cccnc3o2)cc1.[Li+].[OH-]>>O=C(O)c1ccc(-c2nc3cccnc3o2)cc1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.NC1CCN(CCn2c(=O)cnc3ccc(F)c(F)c32)CC1.O=Cc1ccc2c(n1)NC(=O)CO2.[Na+]>>O=C1COc2ccc(CNC3CCN(CCn4c(=O)cnc5ccc(F)c(F)c54)CC3)nc2N1",
        "output": "775"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(N2CCC(Cc3ccccc3)CC2)c(C#N)c1.COc1ccc(N2CCN(CCc3ccccc3)CC2)cc1C>>N#Cc1cc(O)ccc1N1CCC(Cc2ccccc2)CC1",
        "output": "402"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1c(C(C)C)cc(C=O)cc1C(C)C.Cc1cc(Cl)c2c(c1)CC(=O)N2>>COc1c(C(C)C)cc(C=C2C(=O)Nc3c(Cl)cc(C)cc32)cc1C(C)C",
        "output": "439"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CO.Cc1ncnc2c1c(NCc1ccc(O)c(O)c1)cc(=O)n2OCc1ccccc1.[C].[H][H].[Pd]>>Cc1ncnc2c1c(NCc1ccc(O)c(O)c1)cc(=O)n2O",
        "output": "630"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCO.COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1cc(OC)c2c(c1)OCO2)c1cn(C)c2cc(C=O)ccc12.Cl.O.[BH4-].[Na+]>>COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1cc(OC)c2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12",
        "output": "356"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCCCS.CCO.OCC(O)CBr.[K+].[OH-]>>CCCCCCCCCCCCSCC(O)CO",
        "output": "185"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1sc2cnccc2c1Br.C#CC(C)(C)O.C1COCCO1.CCN(C(C)C)C(C)C.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>CC(C)(O)C#Cc1sc2cnccc2c1Br",
        "output": "766"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CSC1(c2c(C#N)nn(-c3c(Cl)cc(C(F)(F)F)cc3Cl)c2N)CC1(F)F.ClCCl.O=C(OO)c1cccc(Cl)c1>>CS(=O)C1(c2c(C#N)nn(-c3c(Cl)cc(C(F)(F)F)cc3Cl)c2N)CC1(F)F",
        "output": "13"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)Cc1ccc(Oc2ccc(C(=O)NCCc3ccc(Cl)cc3)cc2)c(C#N)c1.CO.N.[H][H].[Ni]>>CC(C)(C)OC(=O)Cc1ccc(Oc2ccc(C(=O)NCCc3ccc(Cl)cc3)cc2)c(CN)c1",
        "output": "175"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC=CC=CCCC(=O)OCC.CCCCCCC.Cl.[K+].[OH-]>>CC=CC=CCCC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCN1.C1COCCO1.CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.COc1ccc(Nc2ncc(Br)cc2-c2nc(C)nc3c2ncn3C2CCCCO2)cn1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>COc1ccc(Nc2ncc(N3CCOCC3)cc2-c2nc(C)nc3c2ncn3C2CCCCO2)cn1",
        "output": "597"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc(CN)nc1OC.Cc1cncc(-c2cc(C(=O)O)c(N3CCCC3)cn2)c1.F[P-](F)(F)(F)(F)F>>COc1ccc(CNC(=O)c2cc(-c3cncc(C)c3)ncc2N2CCCC2)nc1OC",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.F[P-](F)(F)(F)(F)F.N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)c1nc2ccccc2s1.O.O=C(O)C1CCOCC1>>O=C(NCCCC[C@H](NC(=O)C1CCOCC1)C(=O)c1nc2ccccc2s1)OCc1ccccc1",
        "output": "645"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COCCn1cc(C(=O)O)c(=O)cc1C.ClCCl.O.O=C(O)C(F)(F)F.O=C1CCC(=O)N1I>>COCCn1cc(C(=O)O)c(=O)c(I)c1C",
        "output": "783"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCCNCC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)CNC(=O)OCc1ccccc1>>O=C(NCC(=O)N1CCCCCC1)OCc1ccccc1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.Cl.FC1(CCC2c3c(Cl)cccc3-c3cncn32)CCC2(CC1)OCCO2.O=C([O-])O.[Na+]>>O=C1CCC(F)(CCC2c3c(Cl)cccc3-c3cncn32)CC1",
        "output": "251"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CI.CN(C)C=O.COc1ccc(CO[C@@H]2[C@@H]([C@H](C)O)O[C@@H]3SC(N(C)C)=N[C@@H]3[C@H]2OCc2ccc(OC)cc2)cc1.[H-].[Na+]>>COc1ccc(CO[C@@H]2[C@@H]([C@H](C)OC)O[C@@H]3SC(N(C)C)=N[C@@H]3[C@H]2OCc2ccc(OC)cc2)cc1",
        "output": "140"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.Cc1c(N)cccc1Cl.O>>CC(=O)Nc1cccc(Cl)c1C",
        "output": "365"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)c1sc2nnc3c(c2c1N)CCCC3.Cl.ClCCl.[K+].[OH-]>>Nc1c(C(=O)O)sc2nnc3c(c12)CCCC3",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=C(C)n1c(=O)[nH]c2ccccc21.CN(C)C=O.ClCCCCCCCl.[H-].[Na+]>>C=C(C)n1c(=O)n(CCCCCCCl)c2ccccc21",
        "output": "611"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)CCNc1ccc(Cl)cc1C(=O)N(CCc1cccc(C(F)(F)F)c1)Cc1ccc(C(C)(C)C)cc1.[Na+].[OH-]>>CC(C)(C)c1ccc(CN(CCc2cccc(C(F)(F)F)c2)C(=O)c2cc(Cl)ccc2NCCC(=O)O)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C(=O)O)c1ccc(Cl)cc1.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.CN1CCOCC1.CS(C)=O.F[P-](F)(F)(F)(F)F.O=C(O)C(F)(F)F.OC[C@H]1NCCc2ccccc21>>CC(C)(C(=O)N1CCc2ccccc2[C@H]1CO)c1ccc(Cl)cc1",
        "output": "633"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(N)c1.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(NC(=O)C(F)(F)F)c1",
        "output": "106"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N(C)C.CC(=O)[O-].CC(=O)[O-].COC(=O)c1c[nH]nc1C.COc1ccccc1B(O)O.[Cu+2].c1ccncc1>>COC(=O)c1cn(-c2ccccc2OC)nc1C",
        "output": "925"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCc1csc(C=O)c1.CO.[BH4-].[Cl-].[NH4+].[Na+]>>CCc1csc(CO)c1",
        "output": "529"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CC#N.CCN(CC)CC.CN(C)C=O.Cc1nccn1-c1ccc(C(=O)O)cc1.F[P-](F)(F)(F)(F)F.Fc1cc(C(F)(F)F)cnc1N1CCC(NC2CC2)CC1.O.O=C(O)C(F)(F)F>>Cc1nccn1-c1ccc(C(=O)N(C2CC2)C2CCN(c3ncc(C(F)(F)F)cc3F)CC2)cc1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COCCOCCO.C[C@@](CO)(C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)c1cnn[nH]1)C(=O)O.Cl>>COCCOCCOC(=O)[C@](C)(CO)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)c1cnn[nH]1",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.COc1ccccc1N1CCNCC1.O=C([O-])[O-].O=C1CNC(=O)N1CCCCCl.[K+].[K+]>>COc1ccccc1N1CCN(CCCCN2C(=O)CNC2=O)CC1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)I.Cc1ccc(O)cc1Cl>>Cc1ccc(OC(C)C)cc1Cl",
        "output": "318"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCC(Oc1ccccc1)c1ccc(C(=O)OC)cc1.CO.Cl.O>>CCC(Oc1ccccc1)c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCOC(=O)C(CC(C)C)c1cc(-c2ccc(C(F)(F)F)cc2)cc(C2CCCNC2)c1.CS(=O)(=O)Cl.ClCCl>>CCOC(=O)C(CC(C)C)c1cc(-c2ccc(C(F)(F)F)cc2)cc(C2CCCN(S(C)(=O)=O)C2)c1",
        "output": "584"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.COC(=O)C1=C(c2ccc(CCCO[Si](C)(C)C(C)(C)C)cc2)C2(CC2)CN(C(=O)OC(C)(C)C)C1.[F-]>>COC(=O)C1=C(c2ccc(CCCO)cc2)C2(CC2)CN(C(=O)OC(C)(C)C)C1",
        "output": "708"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1ncnc2ccccc12.O=C(O)C1CCN(c2cccc(C(F)(F)F)c2)CC1>>O=C(Nc1ncnc2ccccc12)C1CCN(c2cccc(C(F)(F)F)c2)CC1",
        "output": "368"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCCc1ccccc1.CCOC(C)=O.CN(C)C=O.Clc1ccc(-c2cc(C3CCNCC3)[nH]n2)cc1.O=C([O-])[O-].[K+].[K+]>>Clc1ccc(-c2cc(C3CCN(CCc4ccccc4)CC3)[nH]n2)cc1",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1NCCc2cc(-c3ccnc(F)c3)ccc21.O=C(O)c1cc2ncc(Br)cn2n1>>CN1c2ccc(-c3ccnc(F)c3)cc2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "995"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.ClCCl.O=[N+]([O-])c1cc(CO)ccc1Cl>>CS(=O)(=O)OCc1ccc(Cl)c([N+](=O)[O-])c1",
        "output": "0"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=O)O.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClC(Cl)Cl.Nc1ccc(Cl)c(-c2nc3cc(C(F)(F)F)ccc3s2)c1>>CCC(=O)Nc1ccc(Cl)c(-c2nc3cc(C(F)(F)F)ccc3s2)c1",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COc1ccc(CN2C(=O)N(C)C(C[N+](=O)[O-])(C(F)(F)F)c3cc(Br)ccc32)cc1.O.[Cl-].[Fe].[NH4+]>>COc1ccc(CN2C(=O)N(C)C(CN)(C(F)(F)F)c3cc(Br)ccc32)cc1",
        "output": "226"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)OB(c2cccc(N)c2)OC1(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[P-](F)(F)(F)(F)F.O.O=C(O)c1ccc2cc3n(c2c1)CCCNC3=O>>CC1(C)OB(c2cccc(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)c2)OC1(C)C",
        "output": "50"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCC[N+](CCC)(CCC)CCC.C[N+]1([O-])CCOCC1.O=[Ru](=O)(=O)[O-].OCCCOc1ccc(CO)cc1>>O=Cc1ccc(OCCCO)cc1",
        "output": "179"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.COC(=O)Cl.Nc1cc(-c2nc(-c3ccco3)no2)ccc1Cl.O=C([O-])[O-].[K+].[K+]>>COC(=O)Nc1cc(-c2nc(-c3ccco3)no2)ccc1Cl",
        "output": "102"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)N.CSc1sc(C(=O)O)c(-c2ccc(C(=O)O)cc2)c1C#N.Cl.ClCCl.O.O=C(n1ccnc1)n1ccnc1>>CSc1sc(C(=O)O)c(-c2ccc(C(=O)NC(C)C)cc2)c1C#N",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)C(OC(C)(C)C)c1c(C)nc2sc3c(c2c1-c1ccc(C)cc1)CCCC3.[Na+].[OH-]>>Cc1ccc(-c2c(C(OC(C)(C)C)C(=O)O)c(C)nc3sc4c(c23)CCCC4)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.Cc1ccc(N=C=O)cc1.Nc1ccc(Oc2ccc(-c3c[nH]c(COc4ccccc4)n3)cc2)cc1>>Cc1ccc(NC(=O)Nc2ccc(Oc3ccc(-c4c[nH]c(COc5ccccc5)n4)cc3)cc2)cc1",
        "output": "912"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)OCc1c(-c2nc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)c3nc[nH]c3n2)cc(F)cc1N1CCn2c(cc3c2CCCC3)C1=O.CC(C)O.O.[Li+].[OH-]>>O=C1c2cc3c(n2CCN1c1cc(F)cc(-c2nc(Nc4ccc(N5CCN(C6COC6)CC5)cc4)c4nc[nH]c4n2)c1CO)CCCC3",
        "output": "497"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COc1cccc(OC)c1CN.O.O=C(O)c1ccc2cnccc2n1.On1nnc2ccccc21>>COc1cccc(OC)c1CNC(=O)c1ccc2cnccc2n1",
        "output": "905"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrC(Br)(Br)Br.CC(=O)Oc1ccc(CO)cc1.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(=O)Oc1ccc(CBr)cc1",
        "output": "750"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.Cc1ccc(C2(N(C)C)CCC3(CCNC3=O)CC2)s1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>Cc1ccc(C2(N(C)C)CCC3(CCNC3)CC2)s1",
        "output": "112"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(F)c(NC(=O)c2cnc3ccccn23)c1.Cl.O.O.[Li]O>>O=C(O)c1ccc(F)c(NC(=O)c2cnc3ccccn23)c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)CON=C(C(=O)O)c1csc(NC=O)n1.CCOC(C)=O.CN(C)C=O.C[Si](C)(C)C(C(N)=O)[Si](C)(C)C.C[Si](C)(C)CC(N)=O.NC1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(O)CS[C@H]12.O.O=P(Cl)(Cl)Cl>>CC(C)CON=C(C(=O)NC1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(O)CS[C@H]12)c1csc(NC=O)n1",
        "output": "587"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN=C=O.NC(=O)c1ccc(OC2CNC2)cc1>>CNC(=O)N1CC(Oc2ccc(C(N)=O)cc2)C1",
        "output": "437"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1c(C2CCC2)ccc(B(O)O)c1F.N#Cc1nc(Br)cnc1N>>COc1c(C2CCC2)ccc(-c2cnc(N)c(C#N)n2)c1F",
        "output": "876"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Br.Br.CC1CCN(c2nc(N3CCNCC3)ccc2[N+](=O)[O-])CC1.CCN(CC)CC.ClCCl.O=C(CCl)N1CCOCC1>>CC1CCN(c2nc(N3CCN(CC(=O)N4CCOCC4)CC3)ccc2[N+](=O)[O-])CC1",
        "output": "340"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cn(C(CC2CCS(=O)(=O)CC2)C(=O)OC(C)(C)C)c(=O)cc1-c1cc(Cl)ccc1C#N.ClCCl.O=C(O)C(F)(F)F>>COc1cn(C(CC2CCS(=O)(=O)CC2)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1C#N",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COCCCc1ccc(Cl)c(CN(C(=O)C(CNC(=O)OC(C)(C)C)Cc2ccc(OCCOc3c(Cl)cc(CCCO)cc3Cl)cc2)C2CC2)c1.Cl.ClCCl>>COCCCc1ccc(Cl)c(CN(C(=O)C(CN)Cc2ccc(OCCOc3c(Cl)cc(CCCO)cc3Cl)cc2)C2CC2)c1",
        "output": "538"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc2cc(B(O)O)sc2c1.O=C(CN1CCCC1)Nc1ccc(Br)cc1>>COc1ccc2cc(-c3ccc(NC(=O)CN4CCCC4)cc3)sc2c1",
        "output": "903"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.ClCCl.Nc1cc([N+](=O)[O-])ccc1CO.[Mn+4].[O-2].[O-2]>>Nc1cc([N+](=O)[O-])ccc1C=O",
        "output": "179"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CC(=O)O.CCOCC.O=C1CCCc2n[nH]cc21>>O=C1c2c[nH]nc2CCC1Br",
        "output": "82"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCC/C=C/C(=O)O.COC(=O)c1ccc(CN2CCNCC2)cc1.Cl.Cl>>CCCCCCC/C=C/C(=O)N1CCN(Cc2ccc(C(=O)OC)cc2)CC1",
        "output": "870"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)CC(C)c1nc2c(C)ncc(C)n2n1.Cl.[Li+].[OH-]>>Cc1ncc(C)n2nc(C(C)CC(=O)O)nc12",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COc1ccc(Br)c([N+](=O)[O-])c1.COc1cccc(N)c1.Cl.[Na+].[OH-]>>COc1ccc(Br)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.COC(=O)C1(Cc2ccc(Cl)cc2)CCC(C)(CO)C1=O.Cc1ccc(S(=O)(=O)Cl)cc1.Cc1ccccc1.Cn1ccnc1.O>>COC(=O)C1(Cc2ccc(Cl)cc2)CCC(C)(COS(=O)(=O)c2ccc(C)cc2)C1=O",
        "output": "197"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.CO.COc1cc(Br)cc(C(N)=O)c1.CSC.Cl>>COc1cc(Br)cc(CN)c1",
        "output": "215"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=S(=O)([O-])O.OCCCCc1ccc(O)cc1.[H-].[K+].[Na+]>>OCCCCc1ccc(OCc2ccccc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)CC=C1CCC2(CC1)SC(CC(=O)OC(C)(C)C)C(=O)N2CCC(=O)O.CCI.CCOC(C)=O.CN(C)C=O.Cl.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CCN1C(=O)C(CC(=O)OC(C)(C)C)SC12CCC(=CCC(C)C)CC2",
        "output": "196"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.CCOCC.COc1cc(F)ccc1-c1nn(C)c(OC(F)F)c1Br.ClCCl.O>>Cn1nc(-c2ccc(F)cc2O)c(Br)c1OC(F)F",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.Cl.Cl.O.O=CO.OC1(C(CN2CCNCC2)c2cccc(OC(F)(F)F)c2)CCCCC1.[Na+].[OH-]>>CN1CCN(CC(c2cccc(OC(F)(F)F)c2)C2(O)CCCCC2)CC1",
        "output": "217"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=[N+]([O-])c1ccccc1OCCCCl.c1ccc(C(OC2CCNCC2)c2ccncc2)cc1>>O=[N+]([O-])c1ccccc1OCCCN1CCC(OC(c2ccccc2)c2ccncc2)CC1",
        "output": "138"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(C2(C(=O)Cl)CCCCC2)cc1.NNc1cccc2ncccc12>>COc1ccc(C2(C(=O)NNc3cccc4ncccc34)CCCCC2)cc1",
        "output": "450"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1.CCOC(C)=O.Cl[Sn](Cl)(Cl)Cl.O.O.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N1CCN(Cc2ccc(N)cc2)CC1",
        "output": "507"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(C(=O)O)c1cccc2cnccc12.NCc1ccc(C(F)(F)F)cc1.O=C(O)Cc1cccc2cnccc12>>CCC(C(=O)NCc1ccc(C(F)(F)F)cc1)c1cccc2cnccc12",
        "output": "599"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)[Si](C)(C)OCCc1ccsc1C=O.CC(C)(C)[Si](C)(C)OCCc1csc(C=O)c1.CC(C)c1nc(C(=O)N2CCOC3(CCNCC3)C2)cs1.CN1CCCC1=O.O.O=C(O)C(F)(F)F.[Na+]>>CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4cc(CCO[Si](C)(C)C(C)(C)C)cs4)CC3)C2)cs1",
        "output": "792"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.CN(C)C=O.COc1c(Br)cc(Cc2ccccc2)cc1Br.[Li]CCCC>>COc1c(Br)cc(Cc2ccccc2)cc1C=O",
        "output": "638"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=Cc1ccc(F)c(F)c1.Oc1ccc(Cl)c(C(F)(F)F)c1>>O=Cc1ccc(Oc2ccc(Cl)c(C(F)(F)F)c2)c(F)c1",
        "output": "564"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#C[C@](C)(O)c1ccccn1.CNC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(Br)cc1-2>>CNC(=O)c1c(C(N)=O)nc2n1CCOc1cc(F)c(C#C[C@](C)(O)c3ccccn3)cc1-2",
        "output": "659"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCCBr.CC#N.O=C([O-])[O-].O=[N+]([O-])c1ccc(S)cc1.[K+].[K+]>>O=[N+]([O-])c1ccc(SCCBr)cc1",
        "output": "124"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)c1coc(C(=O)CCCCCCc2ccccc2)n1.Cl.O.[Li+].[OH-]>>O=C(O)c1coc(C(=O)CCCCCCc2ccccc2)n1",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.CS(=O)(=O)Nc1cccc(CN2CN(c3ccccc3)C3(CCN(C(=O)OCc4ccccc4)CC3)C2=O)c1.[Pd]>>CS(=O)(=O)Nc1cccc(CN2CN(c3ccccc3)C3(CCNCC3)C2=O)c1",
        "output": "428"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.C[C@@H]1CC[C@@H](O)CN1C(=O)c1ccccc1-n1nccn1.Fc1nccc(C(F)(F)F)c1F.[H-].[Na+]>>C[C@@H]1CC[C@@H](Oc2nccc(C(F)(F)F)c2F)CN1C(=O)c1ccccc1-n1nccn1",
        "output": "541"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)NC1CCN(CCN2C(=O)COc3ccc(C#N)cc32)C(=O)C1.COc1ccc2c(c1)N(CCN1CCC(N)CC1)C(=O)OC2.O=C(O)C(F)(F)F>>N#Cc1ccc2c(c1)N(CCN1CCC(N)CC1=O)C(=O)CO2",
        "output": "538"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(C)=O.Fc1cccc(CNc2nc(-c3cc(F)ncc3Cl)ccc2F)c1.N[C@H]1CC[C@H](N)CC1>>N[C@@H]1CC[C@@H](Nc2cc(-c3ccc(F)c(NCc4cccc(F)c4)n3)c(Cl)cn2)CC1",
        "output": "810"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCOC(=O)COc1ccc(COc2cccc(C(=O)c3ccccc3)c2N)cc1.ClCCl.O=C(Cl)OCc1cccc2c1Cc1ccccc1-2.c1ccncc1>>C=CCOC(=O)COc1ccc(COc2cccc(C(=O)c3ccccc3)c2NC(=O)OCc2cccc3c2Cc2ccccc2-3)cc1",
        "output": "509"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#C[C@]1(O)CCN(C)C1=O.N#Cc1ccc(-n2nc(C(N)=O)c3c2CCCC3)cc1Br>>CN1CC[C@@](O)(C#Cc2cc(-n3nc(C(N)=O)c4c3CCCC4)ccc2C#N)C1=O",
        "output": "659"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cl.N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1.O=C(O)Cc1ccccn1>>O=C(Cc1ccccn1)N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1",
        "output": "133"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCc1c(O)cccc1-c1ccccc1.CI.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>C=CCc1c(OC)cccc1-c1ccccc1",
        "output": "62"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC[C@H]1CC[C@H](CC[C@@H]2CC[C@@H](C(=O)O)CC2)CC1.CCO.O.O=S(=O)(O)O>>CCC[C@H]1CC[C@H](CC[C@@H]2CC[C@@H](C(=O)OCC)CC2)CC1",
        "output": "47"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CBr.CN(C)C=O.O=C([O-])[O-].OC1(c2ccc(-c3ccc(Nc4ccc(C(F)(F)F)nc4)nc3)cc2)CCNCC1.[K+].[K+]>>CCOC(=O)CN1CCC(O)(c2ccc(-c3ccc(Nc4ccc(C(F)(F)F)nc4)nc3)cc2)CC1",
        "output": "467"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccccc1.Oc1ccc2ccccc2c1.[Br-].c1ccc2cc(OCC3CO3)ccc2c1>>OC(COc1ccc2ccccc2c1)COc1ccc2ccccc2c1",
        "output": "277"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrBr.O=C(O)Cc1ccc(Cl)cc1.O=S(Cl)Cl>>O=C(Cl)Cc1ccc(Cl)cc1",
        "output": "53"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCc1cc(-c2noc(-c3cc(OC)nc(C4CCCC4)c3)n2)cc(C)c1OCCCOS(C)(=O)=O.CN>>CCc1cc(-c2noc(-c3cc(OC)nc(C4CCCC4)c3)n2)cc(C)c1OCCCNC",
        "output": "559"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(=O)(=O)Cl.C[C@H](N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1>>C[C@H](NS(C)(=O)=O)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1",
        "output": "742"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.CC(=O)c1ccc(Br)cc1.ClCCl.O>>O=C(CBr)c1ccc(Br)cc1",
        "output": "173"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1ccc(O)cc1F.O=[N+]([O-])c1ccc(O)c(F)c1>>Nc1ccc(O)c(F)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(=O)c1cc2c(c(C=O)c1O)OCO2.CC(C)(C)OC(=O)N1CCNCC1.ClCCl.[Na+]>>CC(=O)c1cc2c(c(CN3CCN(C(=O)OC(C)(C)C)CC3)c1O)OCO2",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOc1ccc(CCl)cc1.CN(C)C=O.COC(=O)Cc1coc2cc(O)ccc12.O.O=C([O-])[O-].[K+].[K+]>>CCOc1ccc(COc2ccc3c(CC(=O)OC)coc3c2)cc1",
        "output": "49"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2cccc3cc(C#N)ccc23)CC1.CO.ClCCl.O=C(O)C(F)(F)F.O=C([O-])[O-].[K+].[K+]>>N#Cc1ccc2c(C3CCNCC3)cccc2c1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cc1ccc(S(=O)(=O)OCC2CCN(C(=O)c3cccc(C)c3)CC2)cc1.O=C([O-])[O-].[K+].[K+].c1ccc2c3c([nH]c2c1)CNCC3>>Cc1cccc(C(=O)N2CCC(CN3CCc4c([nH]c5ccccc45)C3)CC2)c1",
        "output": "429"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)/N=N/C(=O)OCC.CSCCC(CO)NC(=O)OC(C)(C)C.O=C1NC(=O)c2ccccc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CSCCC(CN1C(=O)c2ccccc2C1=O)NC(=O)OC(C)(C)C",
        "output": "420"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C1CCc2[nH]c3ccc(N)cc3c2C1.O=C(O)c1ccc(Cl)nc1>>CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(Cl)nc4)cc3c2C1",
        "output": "739"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cl.Nc1ccc(O)cc1Cl.O=C(Cl)OCc1ccccc1.c1ccncc1>>O=C(Nc1ccc(O)cc1Cl)OCc1ccccc1",
        "output": "509"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.O=C1CCC(=O)N1Br.c1ccc(N(c2ccccc2)c2ccc(-c3ccc(-c4cccc5ccccc45)cc3)cc2)cc1>>Brc1ccc(N(c2ccccc2)c2ccc(-c3ccc(-c4cccc5ccccc45)cc3)cc2)cc1",
        "output": "4"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ncc(CCN)c2c1OC(C)(C)OC2.N#Cc1cccc(C(=O)O)c1>>Cc1ncc(CCNC(=O)c2cccc(C#N)c2)c2c1OC(C)(C)OC2",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)c1cc(-c2ccc(F)cc2)sc1NC(=O)Nc1c(Cl)cccc1Cl.ClC(Cl)Cl.O=C(O)C(F)(F)F>>O=C(Nc1sc(-c2ccc(F)cc2)cc1C(=O)O)Nc1c(Cl)cccc1Cl",
        "output": "569"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)c1ccc(C(F)(F)F)cc1C(F)(F)F.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.[Br-].[Br-].[Br-]>>O=C(CBr)c1ccc(C(F)(F)F)cc1C(F)(F)F",
        "output": "360"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(-c2nc3cc(Br)ccc3o2)cc1[N+](=O)[O-].OB(O)c1cccc(C(F)(F)F)c1>>COc1ccc(-c2nc3cc(-c4cccc(C(F)(F)F)c4)ccc3o2)cc1[N+](=O)[O-]",
        "output": "909"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1CNCCN1c1ccncc1[N+](=O)[O-].CI.CN(C)C=O.[H-].[Na+]>>CC1CN(C)CCN1c1ccncc1[N+](=O)[O-]",
        "output": "483"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.COCCO.COc1cc2nc(Cl)nc(N)c2cc1OC.O=C(C1CCCO1)N1CCNCC1>>COc1cc2nc(N3CCN(C(=O)C4CCCO4)CC3)nc(N)c2cc1OC",
        "output": "36"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.CCN(CC)CC.CSCCN.Cc1nc(Cl)c(N)c(Cl)n1>>CSCCNc1nc(C)nc(Cl)c1N",
        "output": "110"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(CN(C)S(=O)(=O)NC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)C[C@H](OCCN(C)Cc1ccccc1)COc1ccccc1-3)OC.[Pd]>>CNCCO[C@@H]1COc2ccccc2-c2c(C3CCCCC3)c3ccc(C(=O)NS(=O)(=O)N(C)CC(OC)OC)cc3n2C1",
        "output": "84"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(=O)OC=CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)OC(C)(C)C)C2SC1.Cc1ccc(S(=O)(=O)O)cc1.O.O=C([O-])O.[Na+]>>CC(=O)OC=CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(N)C2SC1",
        "output": "431"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc(Cn2nc(I)c3c(Oc4ccc(N)cc4F)ccnc32)cc1.O=C(O)C(F)(F)F>>Nc1ccc(Oc2ccnc3[nH]nc(I)c23)c(F)c1",
        "output": "978"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC1CCCCN1C(=O)CCNc1cccc(-c2ccccc2)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC1CCCCN1CCCNc1cccc(-c2ccccc2)c1",
        "output": "112"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(Cl)Cl.CCCN(CCC)c1nc2cccc(OC)c2c(=O)n1C.C[S+](C)[B-](Br)(Br)Br>>CCCN(CCC)c1nc2cccc(O)c2c(=O)n1C",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.C[O-].Clc1ccnc2ccc(Br)cc12.[Na+]>>COc1ccnc2ccc(Br)cc12",
        "output": "651"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCOc1ccc(-c2noc(-c3ccc(C[C@H](NC(=O)c4ccc(C(C)(C)C)cc4)C(=O)OC)cc3)n2)cc1.CO.[Na+].[OH-]>>CCCCCCCOc1ccc(-c2noc(-c3ccc(C[C@H](NC(=O)c4ccc(C(C)(C)C)cc4)C(=O)O)cc3)n2)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Cc1nc(N)nc2c1ccc(=O)n2[C@@H]1CC[C@@H](OCCO)CC1.O.O=C1CCC(=O)N1Br>>Cc1nc(N)nc2c1cc(Br)c(=O)n2[C@@H]1CC[C@@H](OCCO)CC1",
        "output": "518"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CBr.CCCC[N+](CCCC)(CCCC)CCCC.C[C@]1(CO)CCCN(C[C@H]2COc3ccccc3O2)C1.Cc1ccccc1.[Br-].[Na+].[OH-]>>CC(C)(C)OC(=O)COC[C@@]1(C)CCCN(C[C@H]2COc3ccccc3O2)C1",
        "output": "669"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.Cc1noc(-c2ccc(Br)cc2)c1CC(F)(F)CCc1ccccc1>>CCOC(=O)C(C)c1ccc(-c2ccc(-c3onc(C)c3CC(F)(F)CCc3ccccc3)cc2)cc1",
        "output": "933"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCNCCCS(=O)CCC(F)(F)F.Oc1cccc(C2=C(CCCCCCBr)c3ccc(O)cc3CCC2)c1>>CCN(CCCCCCC1=C(c2cccc(O)c2)CCCc2cc(O)ccc21)CCCS(=O)CCC(F)(F)F",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC(C)(C(=O)O)c1ccc(S(=O)(=O)/C=C/C#N)cc1.CCN=C=NCCCN(C)C.CNCc1ccc(F)cc1.Cl.On1nnc2ccccc21>>CN(Cc1ccc(F)cc1)C(=O)C(C)(C)c1ccc(S(=O)(=O)/C=C/C#N)cc1",
        "output": "633"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.COc1ccc2ccccc2c1CCC(=O)O.ClCCl.O=C(Cl)C(=O)Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc2cccc3c2c1CCC3=O",
        "output": "274"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)c1ccc(Cl)c(Cl)c1.CN1CCNCC1.O.[Na+].[OH-]>>CC(=O)c1ccc(N2CCN(C)CC2)c(Cl)c1",
        "output": "105"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)(C)OC(=O)n1c(-c2cc3ccccc3nc2Cl)cc2cc(CO[Si](C)(C)C(C)(C)C)ccc21.CCN(CC)CC.F.F.F>>CC(C)(C)OC(=O)n1c(-c2cc3ccccc3nc2Cl)cc2cc(CO)ccc21",
        "output": "708"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Clc1cncc(Cl)c1N1CCNCC1.FC(F)(F)c1nnc2ccc(Cl)nn12>>FC(F)(F)c1nnc2ccc(N3CCN(c4c(Cl)cncc4Cl)CC3)nn12",
        "output": "406"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1oncc1C(=O)O.Cl.Fc1ccc(-c2nc(C3CCCNC3)no2)c(F)c1>>Cc1oncc1C(=O)N1CCCC(c2noc(-c3ccc(F)cc3F)n2)C1",
        "output": "975"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCOc1cnc(-c2ccc(O)cc2)nc1.FC(F)(COCCCCCBr)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>CCCCCCOc1cnc(-c2ccc(OCCCCCOCC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc2)nc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1ccc(NC(=O)c2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)cc1.O.[Na+].[OH-]>>O=C(O)c1ccc(NC(=O)c2ccc3[nH]nc(-c4ccc(F)cc4)c3c2)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCc1nn2c(N)cc(Cl)nc2c1S(=O)(=O)c1ccccc1.CN(C)C=O.CN1CCNCC1>>CCc1nn2c(N)cc(N3CCN(C)CC3)nc2c1S(=O)(=O)c1ccccc1",
        "output": "162"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CO.Cl.Nc1ccc2ccc(S(=O)(=O)Nc3ccc(Cl)c(C(=O)O)c3)cc2c1>>COC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(N)cc3c2)ccc1Cl",
        "output": "195"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCCC(CNc2ccccc2)C1.COCC(=O)Cl.ClCCl>>COCC(=O)N(CC1CCCN(C(=O)OC(C)(C)C)C1)c1ccccc1",
        "output": "160"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)C1(CC#N)CCNCC1.O=S(=O)(Cl)c1ccccc1Cl.c1ccncc1>>CCOC(=O)C1(CC#N)CCN(S(=O)(=O)c2ccccc2Cl)CC1",
        "output": "99"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CCc1cc(Cl)ccn1.CCOC(C)=O.O=C(OO)c1cccc(Cl)c1>>CC(C)(C)OC(=O)CCc1cc(Cl)cc[n+]1[O-]",
        "output": "262"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1oc2cccc(OCCCBr)c2c1C.CO.Cl.O.O.[Li]O>>Cc1c(C(=O)O)oc2cccc(OCCCBr)c12",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(=O)Nc1cc(-n2c(C)cc(=O)c3ccc(Br)cc32)c(F)cc1F.O=[Se]=O>>CC(=O)Nc1cc(-n2c(C=O)cc(=O)c3ccc(Br)cc32)c(F)cc1F",
        "output": "619"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.Cc1ccc(C(F)(F)F)cc1Br.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br.c1ccccc1>>FC(F)(F)c1ccc(CBr)c(Br)c1",
        "output": "29"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)NS(=O)(=O)c1ccc(Cl)c(C(=O)O)c1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CNS(=O)(=O)c1ccc(Cl)c(C(=O)N2CCC(CCN3C4CCC3CC(n3c(C)nc5ccccc53)C4)(c3cccc(F)c3)CC2)c1Cl.Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2cccc(F)c2)CCNCC1.F[P-](F)(F)(F)(F)F>>Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2cccc(F)c2)CCN(C(=O)c2cc(S(=O)(=O)NC(C)(C)C)ccc2Cl)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCc1cccc(CNC[C@@H](O)[C@@H](N)Cc2cc(F)cc(F)c2)c1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(=O)CCc1cnc(-c2cccc(C(=O)O)c2)o1.Cl.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>CCc1cccc(CNC[C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2cccc(-c3ncc(CCC(=O)OC)o3)c2)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.COC(=O)c1ccc(O)cc1O.O=C([O-])[O-].O=C1c2ccccc2C(=O)N1OCCCBr.[Cs+].[Cs+]>>COC(=O)c1ccc(OCCCON2C(=O)c3ccccc3C2=O)cc1O",
        "output": "385"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.Cc1cc(C(F)(F)F)ccc1B(O)O.Cl[Pd]Cl.Fc1cccc(Cl)c1-c1cc2nc(Br)ccc2[nH]1.O.O=C([O-])[O-].[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1cc(C(F)(F)F)ccc1-c1ccc2[nH]c(-c3c(F)cccc3Cl)cc2n1",
        "output": "869"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(Nc2nccc(OC(C)C)n2)cc(-c2cnc(C3(O)CCC(C(=O)O)C(C)(C)C3)s2)n1.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Cl-].[NH4+].[Na+]>>Cc1cc(Nc2nccc(OC(C)C)n2)cc(-c2cnc(C3(O)CCC(C(N)=O)C(C)(C)C3)s2)n1",
        "output": "313"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1NCCc2sc(F)c(F)c21.O=C(O)c1cc2ncc(Cl)cn2n1>>CC1c2c(sc(F)c2F)CCN1C(=O)c1cc2ncc(Cl)cn2n1",
        "output": "663"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc(CNC23CC4CC(CC(C4)C2)C3)nc1.OB(O)c1ccccc1Cl>>Clc1ccccc1-c1ccc(CNC23CC4CC(CC(C4)C2)C3)nc1",
        "output": "833"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)C=O.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.NCCN1c2ccccc2Sc2ccc(Cl)cc21>>Cc1ccc(S(=O)(=O)NCCN2c3ccccc3Sc3ccc(Cl)cc32)cc1",
        "output": "43"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)C(CC1CC1)[C@@H]1c2ccccc2C[C@H]1N.Cl.O.O=C(O)c1cc2sc(Cl)c(Cl)c2[nH]1.On1nnc2ccccc21>>COC(=O)C(CC1CC1)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1",
        "output": "137"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1ccc(-c2cnc(CCNS(=O)(=O)C(F)(F)F)s2)cc1.O=C=Nc1c(F)cc(F)cc1F>>O=C(Nc1ccc(-c2cnc(CCNS(=O)(=O)C(F)(F)F)s2)cc1)Nc1c(F)cc(F)cc1F",
        "output": "473"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)CCC(C)(C)c2cc(-c3cccc(N4CCC(=O)CC4)n3)ccc21.Cl.NCC[C@H](O)CO>>CC1(C)CCC(C)(C)c2cc(-c3cccc(N4CCC(NCC[C@H](O)CO)CC4)n3)ccc21",
        "output": "236"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(CC(C)(C)C)c1ccc(CNC(=O)OC(C)(C)C)cc1.CCOC(C)=O.Cl>>CC(CC(C)(C)C)c1ccc(CN)cc1",
        "output": "793"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccc(Cl)cc21)=[N+](C)C.CN(C)C=O.Cc1oc(=O)oc1COC(=O)[C@H](O)C[C@H](N)Cc1ccc(-c2cccc(Cl)c2)cc1.Cn1nc(C(=O)O)cc1O.F[P-](F)(F)(F)(F)F>>Cc1oc(=O)oc1COC(=O)[C@H](O)C[C@@H](Cc1ccc(-c2cccc(Cl)c2)cc1)NC(=O)c1cc(O)n(C)n1",
        "output": "816"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.Cc1cc(C)c(-c2c(OC(=O)C(C)(C)C)cc(CCO)oc2=O)c(C)c1>>Cc1cc(C)c(-c2c(OC(=O)C(C)(C)C)cc(CCOS(C)(=O)=O)oc2=O)c(C)c1",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](N)CCCNC(=N)NS(=O)(=O)c1ccc(C)cc1)C(N)=O.On1nnc2ccccc21>>CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCNC(=N)NS(=O)(=O)c1ccc(C)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)C(N)=O",
        "output": "133"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.ClC(Cl)Cl.Fc1ccc([C@H]2CCCN2)cc1>>Cc1ccc(S(=O)(=O)N2CCC[C@@H]2c2ccc(F)cc2)cc1",
        "output": "900"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)N1CC2CC(CN(Cc3ccccc3)C2)C1.CO.O.[Na+].[OH-].[Pd]>>CC(C)N1CC2CNCC(C2)C1",
        "output": "84"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)Oc1cccc(O)c1.CC(C)[Si](Cl)(C(C)C)C(C)C.C[Si](C)(C)[N-][Si](C)(C)C.[Li+]>>CC(=O)Oc1cccc(O[Si](C(C)C)(C(C)C)C(C)C)c1",
        "output": "746"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1ccc2oc(=O)cc(NC3CCNCC3)c2c1.N.O=Cc1ccc2c(c1)OCO2>>CCc1ccc2oc(=O)cc(NC3CCN(Cc4ccc5c(c4)OCO5)CC3)c2c1",
        "output": "567"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)CCc1cccn1-c1ccc(C#N)cc1C.CN(C)C=O.O.O=C1CCC(=O)N1Br>>CCOC(=O)CCc1ccc(Br)n1-c1ccc(C#N)cc1C",
        "output": "779"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCCCN.CCN=C=NCCCN(C)C.CN(C)C=O.On1nnc2ccccc21.[N-]=[N+]=Nc1ccc(C(=O)O)cc1>>CCCCNC(=O)c1ccc(N=[N+]=[N-])cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1ncn2c1CN(C)C(=O)c1c(Cl)cccc1-2.O.[Na+].[OH-]>>CN1Cc2c(C(=O)O)ncn2-c2cccc(Cl)c2C1=O",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.C1CCOC1.CC(C)(C)OC(=O)C1CC(=O)C1.CO.O.O=C([O-])[O-].[BH4-].[Na+].[Na+].[Na+]>>CC(C)(C)OC(=O)C1CC(O)C1",
        "output": "91"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOCC.ClCCl.Cl[Pd]Cl.N#C/C(=C\\c1cccnc1)c1c[nH]c2ccc(Br)cc12.O=P([O-])([O-])[O-].OB(O)c1ccc(F)cc1.[Fe+2].[K+].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>N#C/C(=C\\c1cccnc1)c1c[nH]c2ccc(-c3ccc(F)cc3)cc12",
        "output": "837"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)C[AlH]CC(C)C.CCOC(=O)c1cn(-c2ccc(Cc3c(CC)nn4c(C)cc(C)nc34)cc2)nc1C.ClCCl>>CCc1nn2c(C)cc(C)nc2c1Cc1ccc(-n2cc(CO)c(C)n2)cc1",
        "output": "471"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cccc(C(F)(F)F)c1.Nc1ncc2c(n1)CCN(c1cccc(C(=O)O)c1)C2>>Nc1ncc2c(n1)CCN(c1cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c1)C2",
        "output": "50"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.OCCCCCCCCOc1ncc(C(F)(F)F)cc1C(F)(F)F>>O=CCCCCCCCOc1ncc(C(F)(F)F)cc1C(F)(F)F",
        "output": "142"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N[C@H]1CC[C@H](O)CC1.O=C(O)C(c1c2c(nn1-c1ccc(Cl)cc1)CCCC2)C1CCCCC1>>O=C(N[C@@H]1CC[C@@H](O)CC1)C(c1c2c(nn1-c1ccc(Cl)cc1)CCCC2)C1CCCCC1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.NNc1cc(N2CCOCC2)n2nc(-c3ccccc3)cc2n1.O=C(O)C(F)(F)F.O=Cc1ccc(Cl)cc1>>Clc1ccc(C=NNc2cc(N3CCOCC3)n3nc(-c4ccccc4)cc3n2)cc1",
        "output": "167"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCCBr.CS(C)=O.Cn1nc(-c2ccc(O)cc2)cc1N.O.O=C([O-])[O-].[Cs+].[Cs+]>>COCCOc1ccc(-c2cc(N)n(C)n2)cc1",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1cc(-c2ccc(F)cc2)ccc1O.N>>NC(=O)c1cc(-c2ccc(F)cc2)ccc1O",
        "output": "67"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CNC.O=C(CBr)NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1.O=C(Cl)CBr>>CN(C)CC(=O)NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1",
        "output": "443"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=S(Cl)Cl.O=c1[nH]c(=O)n(CCO)c2ccccc12>>O=c1[nH]c(=O)n(CCCl)c2ccccc12",
        "output": "96"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNCC1.CC(=O)c1c(O)c2ccccc2oc1=O.COCCOC(=O)Nc1cccc(C=O)c1.ClC(Cl)Cl.O>>COCCOC(=O)Nc1cccc(C=CC(=O)c2c(O)c3ccccc3oc2=O)c1",
        "output": "295"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)c1ccccc1COc1ccc(CCNC(=O)Nc2ccc(F)cc2F)cc1.O.[Li+].[OH-]>>O=C(NCCc1ccc(OCc2ccccc2C(=O)O)cc1)Nc1ccc(F)cc1F",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)CCc1ccc2[nH]cc(CCN(C)C)c2c1.O.[Li+].[OH-]>>CN(C)CCc1c[nH]c2ccc(CCC(=O)O)cc12",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1ccccc1O.COC(Cl)Cl.Cl.ClCCl.Cl[Ti](Cl)(Cl)Cl>>CCc1cc(C=O)ccc1O",
        "output": "591"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CO.O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccc(CN2CC3CC(C2)N3)cc1>>O=C(N1C2CC1CN(Cc1ccccc1)C2)C(F)(F)F",
        "output": "397"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(C(=O)NC2CNC2)c(F)cc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C.O=C1CCCC1>>COc1cc(C(=O)NC2CN(C3CCCC3)C2)c(F)cc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "187"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCCCCCCCCCCCC(=O)O.N.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)OC(=O)NCCCCCCCCCCCC(N)=O",
        "output": "313"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)[C@@H]1[C@H]2C[C@H]([C@H](N)C2)N1C(=O)OC(C)(C)C.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>COC(=O)[C@@H]1[C@H]2C[C@H]([C@H](NS(=O)(=O)c3ccc(C)cc3)C2)N1C(=O)OC(C)(C)C",
        "output": "43"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C(=O)OC(C)(C)C)C1CCC(Oc2ncnc3sc4c(c23)[C@@H](C[C@H](O)C(N)=O)CC4)CC1.Cl.ClCCl>>CNC1CCC(Oc2ncnc3sc4c(c23)[C@@H](C[C@H](O)C(N)=O)CC4)CC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)CCCN.CO.COc1cc(C=O)ccc1Oc1cnc(C(N)=O)cn1.[BH4-].[Na+]>>COc1cc(CNCCCC(C)(C)C)ccc1Oc1cnc(C(N)=O)cn1",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C1=NOC2(CCC(C(C)(C)C)CC2)C1.CO.O.O.[Li+].[OH-]>>CC(C)(C)C1CCC2(CC1)CC(C(=O)O)=NO2",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=C(Nc1ccc(O)cc1)c1ccccn1.O=C(Nc1ccc(OCc2ccccc2)cc1)c1ccc[nH]1>>O=C(Nc1ccc(O)cc1)c1ccc[nH]1",
        "output": "698"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2c1oc1ccc([N+](=O)[O-])cc12.NN.O.[Ni]>>COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2c1oc1ccc(N)cc12",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C[C@@]1(c2c(F)ccc(N)c2F)C[C@@H](C(F)(F)F)OC(N)=N1.N#Cc1ccc(C(=O)O)nc1>>C[C@@]1(c2c(F)ccc(NC(=O)c3ccc(C#N)cn3)c2F)C[C@@H](C(F)(F)F)OC(N)=N1",
        "output": "985"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(=O)(=O)N1CCC(N)CC1.Nc1nc(Cl)ccc1C(=O)c1ccc(F)cc1.O=C(O)C(F)(F)F>>CS(=O)(=O)N1CCC(Nc2ccc(C(=O)c3ccc(F)cc3)c(N)n2)CC1",
        "output": "70"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(O)C1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(SC3COC(CO)C3)C(C)C12.CS(=O)(=O)Cl.O.c1ccncc1>>CC(O)C1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(SC3COC(COS(C)(=O)=O)C3)C(C)C12",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)Oc1cc(CO)n(C(C)c2ccc(Cl)cc2Cl)n1.CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)Oc1cc(C=O)n(C(C)c2ccc(Cl)cc2Cl)n1",
        "output": "573"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CCN.Cc1cc(C(=O)O)c(C=O)[nH]1>>CCN(CC)CCNC(=O)c1cc(C)[nH]c1C=O",
        "output": "674"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCOc1ccc(-c2ccc(CCCO)cc2)cc1.CCOCC.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CCCCCCCOc1ccc(-c2ccc(CCC=O)cc2)cc1",
        "output": "142"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)O.N#Cc1ccc(OCc2ccccc2)cc1.O.[Cl-].[K+].[Na+].[OH-]>>NC(=O)c1ccc(OCc2ccccc2)cc1",
        "output": "419"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N(C)C.COc1ccc(NC(C)=O)cc1-c1ccnn1C.O.O=C1CCC(=O)N1Br>>COc1ccc(NC(C)=O)cc1-c1c(Br)cnn1C",
        "output": "620"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NC1CCN(c2ccc(CCCn3cncn3)cc2)CC1.O=C(O)C(F)(F)F>>NC1CCN(c2ccc(CCCn3cncn3)cc2)CC1",
        "output": "538"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CNCCN1.CCO.Clc1ccc2cc(Cl)nc(N3CCSCC3)c2c1.O=C([O-])/C=C\\C(=O)[O-].c1ccc(Oc2ccccc2)cc1>>Clc1ccc2cc(N3CCNCC3)nc(N3CCSCC3)c2c1",
        "output": "220"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CCOc1cc(C(CS(C)(=O)=O)N2C(=O)c3cccc(CN)c3C2=O)ccc1OC>>CCOc1cc(C(CS(C)(=O)=O)N2C(=O)c3cccc(CNC(C)=O)c3C2=O)ccc1OC",
        "output": "515"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.COC(=O)c1nc(-c2ccc(Cl)c(OC)c2F)cc(NC(C)=O)c1Cl.O=C([O-])O.O=C=O.[Na+]>>COC(=O)c1nc(-c2ccc(Cl)c(OC)c2F)cc(N)c1Cl",
        "output": "66"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CCNC(=O)c1ccc(NC(c2cc(-c3ccccc3)oc2CSC)C2CCCCC2)cc1.CO.O.O=S([O-])OO.[K+]>>CCOC(=O)CCNC(=O)c1ccc(NC(c2cc(-c3ccccc3)oc2CS(C)(=O)=O)C2CCCCC2)cc1",
        "output": "847"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.NCCCCO.O=Cc1ccccc1.O=[Pt]=O>>OCCCCNCc1ccccc1",
        "output": "468"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cc(NS(=O)(=O)c3ccccc3Cl)cc3ccoc23)CC1.ClCCl.O=C(O)C(F)(F)F>>O=S(=O)(Nc1cc(N2CCNCC2)c2occc2c1)c1ccccc1Cl",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)CC1.CN(C)C=O.Fc1ccc(Br)cc1.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCC(Oc2ccc(Br)cc2)CC1",
        "output": "485"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(OC(CC(C)C)c2sc(-c3ccc(C(F)(F)F)cc3)cc2C)cc1.Cl.O.[Na+].[OH-]>>Cc1cc(-c2ccc(C(F)(F)F)cc2)sc1C(CC(C)C)Oc1ccc(C(=O)O)cc1",
        "output": "222"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.Fc1cc(I)ccn1.Oc1ccccc1.[H-].[Na+]>>Ic1ccnc(Oc2ccccc2)c1",
        "output": "727"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)c1sc(Nc2ncnc3c2CCN(c2ccc(C#N)c(C(F)(F)F)c2)C3)nc1C(F)(F)F.[Na+].[OH-]>>N#Cc1ccc(N2CCc3c(ncnc3Nc3nc(C(F)(F)F)c(C(=O)O)s3)C2)cc1C(F)(F)F",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrC(Br)(Br)Br.ClCCl.OCCCCCCCCCCCSCCC(F)(F)F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>FC(F)(F)CCSCCCCCCCCCCCBr",
        "output": "378"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(C)nc(N2CC3CNCC3C2)n1.F[P-](F)(F)(F)(F)F.O=C(O)c1cccc(F)c1-c1ncccn1>>Cc1cc(C)nc(N2CC3CN(C(=O)c4cccc(F)c4-c4ncccn4)CC3C2)n1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CN(C)C=O.Cl.ClCCN1CCCC1.Fc1cc2ncccc2cc1Cc1cnc2ccc(-c3cn[nH]c3)nn12.O=C([O-])[O-].[Cs+].[Cs+]>>Fc1cc2ncccc2cc1Cc1cnc2ccc(-c3cnn(CCN4CCCC4)c3)nn12",
        "output": "604"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CI.O=C1COc2ccc(Br)c(Oc3ccccc3)c2N1>>CN1C(=O)COc2ccc(Br)c(Oc3ccccc3)c21",
        "output": "237"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)Cc1ccc2c(c1)C(=O)c1ccccc1CN2.CO.O>>O=C(O)Cc1ccc2c(c1)C(=O)c1ccccc1CN2",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Nc1cccc(O)c1.O=C1OC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1c1cccc(O)c1",
        "output": "475"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)c1ccc(CCCNC)cc1.CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.COc1cc(CC(=O)O)ccc1NC(=O)Nc1ccccc1C.Cl.On1nnc2ccccc21>>CCOC(=O)c1ccc(CCCN(C)C(=O)Cc2ccc(NC(=O)Nc3ccccc3C)c(OC)c2)cc1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.CC#N.CCN(C(C)C)C(C)C.O=C(Cl)c1ccc2c(=O)c3ccccc3oc2c1>>O=C(c1ccc2c(=O)c3ccccc3oc2c1)N1CCCC1",
        "output": "201"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.ClCCCl.c1ccc2c(Nc3ccnc4[nH]c5c(c34)CNCC5)cccc2c1>>CC(=O)N1CCc2[nH]c3nccc(Nc4cccc5ccccc45)c3c2C1",
        "output": "369"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)CCOCCCCOCCCCBr.COCCOC.OCc1ccc2c(c1)OCO2.[Br-].[H-].[Na+].[Na+]>>CC(C)CCOCCCCOCCCCOCc1ccc2c(c1)OCO2",
        "output": "95"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CCc1cc(N)n(-c2cccc(C#N)c2)n1.O=C(Cl)OCC(Cl)(Cl)Cl.O=C([O-])O.[Na+].[Na+].[OH-]>>CCc1cc(NC(=O)OCC(Cl)(Cl)Cl)n(-c2cccc(C#N)c2)n1",
        "output": "700"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)P1(=NC(C)(C)C)N(C)CCCN1C.CN1CCCC1=O.Cl.Clc1ncc(C2CC2)cn1.O=C(c1ccc(-c2cnco2)cc1)N(C1CCNCC1)C1CC1>>O=C(c1ccc(-c2cnco2)cc1)N(C1CC1)C1CCN(c2ncc(C3CC3)cn2)CC1",
        "output": "36"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.NN.O.O=[N+]([O-])c1ccc(CNCCN2CCCC2)cc1.[Ni]>>Nc1ccc(CNCCN2CCCC2)cc1",
        "output": "507"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1cccc(C)c1CNc1cc(Cl)nc(NC)c1[N+](=O)[O-].CO.C[O-].Cl.O.[Na+]>>CCc1cccc(C)c1CNc1cc(OC)nc(NC)c1[N+](=O)[O-]",
        "output": "433"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COS(=O)(=O)c1ccc(N)cc1.COc1ccc2sc(C(=O)O)c(OC(C)C)c2c1>>COc1ccc2sc(C(=O)Nc3ccc(S(=O)(=O)OC)cc3)c(OC(C)C)c2c1",
        "output": "822"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)[C@@H](Cc1cc(C)c(OC)c(C)c1)OC(=O)N1CCC(N2CCc3ccccc3NC2=O)CC1.O.[Li+].[OH-]>>COc1c(C)cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc1C",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cc1cc([N+](=O)[O-])ccc1Oc1ccc(CO)[n+]([O-])c1.O=[Pt]=O>>Cc1cc(N)ccc1Oc1ccc(CO)[n+]([O-])c1",
        "output": "335"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.CCC1(N)CCOC1.CCN(C(C)C)C(C)C.COc1ccc2c(Cl)ncnc2c1OC.Cl.O>>CCC1(Nc2ncnc3c(OC)c(OC)ccc23)CCOC1",
        "output": "110"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)OC)CCN3C=O)cc1.CO.[Na+].[OH-]>>CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)O)CCN3C=O)cc1",
        "output": "58"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCOC[C@H](NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C)C(=O)OC.Cl.O.O.[Li+].[OH-]>>CCOC[C@H](NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1ccc(OCCC2CCNCC2)cc1.CN(C)C=O.Cc1ccc(Cl)nn1.ClCCl.O.O=C(O)CCC(=O)O.O=C([O-])[O-].[Na+].[Na+]>>CCOC(=O)c1ccc(OCCC2CCN(c3ccc(C)nn3)CC2)cc1",
        "output": "406"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(CC)CC.CCOC(=O)CC1CCN(c2nc(C(F)(F)F)ccc2N)CC1.O=C(Cl)c1cccc(Cl)c1>>CCOC(=O)CC1CCN(c2nc(C(F)(F)F)ccc2NC(=O)c2cccc(Cl)c2)CC1",
        "output": "501"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CC(C)(C)CCC(=O)O.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.On1nnc2ccccc21>>CC(C)(C)CCC(=O)N1CCCCC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.Nc1ccc(-c2csc(N)n2)cc1.O=C1NC(=O)C(=Cc2ccc([N+](=O)[O-])cc2)N1.[Fe]>>Nc1ccc(C=C2NC(=O)NC2=O)cc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.Oc1ccc2[nH]ccc2c1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1ccc2[nH]ccc2c1",
        "output": "746"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)Cl.Nc1cc(F)c(Cl)cc1F.c1ccncc1>>CCOC(=O)Nc1cc(F)c(Cl)cc1F",
        "output": "102"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Cl.CC(=O)N(C)C.CCOC(C)=O.Nc1cc(CNC(=O)c2ccc(OCC(F)(F)F)nc2)ccn1.c1ccncc1>>CC(=O)Nc1cc(CNC(=O)c2ccc(OCC(F)(F)F)nc2)ccn1",
        "output": "332"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCC(=O)O.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl>>CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCC(=O)Cl",
        "output": "56"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCNCC1.Nc1ncnn2c(-c3ccc(CBr)cc3)cc(-c3ccc4cn(Cc5ccccc5)nc4c3)c12>>CN1CCN(Cc2ccc(-c3cc(-c4ccc5cn(Cc6ccccc6)nc5c4)c4c(N)ncnn34)cc2)CC1",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CI.CN(C)C=O.Cc1nc2ccccc2n1C1C[C@H]2CC[C@@H](C1)N2CCC(C)(CNC(=O)C1CCC(F)(F)CC1)c1ccccc1.O.[H-].[Na+]>>Cc1nc2ccccc2n1C1C[C@H]2CC[C@@H](C1)N2CCC(C)(CN(C)C(=O)C1CCC(F)(F)CC1)c1ccccc1",
        "output": "83"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Brc1ccc(-c2nnc(-c3ccccc3)o2)cc1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.ClCCl.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc(-c3nnc(-c4ccccc4)o3)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)Cc1ccc(B(O)O)cc1.Fc1cccc(-c2nc3cnn(Cc4ccc(Cl)nn4)cc-3n2)c1F>>CC(C)Cc1ccc(-c2ccc(Cn3cc4nc(-c5cccc(F)c5F)nc-4cn3)nn2)cc1",
        "output": "866"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cncc(Br)c1.Cc1ccccc1.O=[N+]([O-])c1cccc(B(O)O)c1.c1ccc([PH](c2ccccc2)(c2ccccc2)[Pd-4]([PH](c2ccccc2)(c2ccccc2)c2ccccc2)([PH](c2ccccc2)(c2ccccc2)c2ccccc2)[PH](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1cncc(-c2cccc([N+](=O)[O-])c2)c1",
        "output": "833"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.COc1ccc(OCC(O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)CNc2ccccc2)cc1.CS(C)=O.c1ccccc1>>COc1ccc(OCC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)CNc2ccccc2)cc1",
        "output": "650"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1=CCCCC1.CCO.Cc1cc([N+](=O)[O-])cc2[nH]ccc12.O.[Pd]>>Cc1cc(N)cc2[nH]ccc12",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1c(-c2noc(-c3cnc(OC(C)C)c(Cl)c3)n2)ccc2c1CCN(C(=O)CNC(=O)OC(C)(C)C)C2.ClCCl.O=C(O)C(F)(F)F>>Cc1c(-c2noc(-c3cnc(OC(C)C)c(Cl)c3)n2)ccc2c1CCN(C(=O)CN)C2",
        "output": "431"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN1CCCC1=O.Cl.N#Cc1cnc(Cl)cn1.O=C(c1ccc(-c2cnco2)cc1)N(C1CCNCC1)C1CC1>>N#Cc1cnc(N2CCC(N(C(=O)c3ccc(-c4cnco4)cc3)C3CC3)CC2)cn1",
        "output": "505"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1cn(CC(=O)OC(C)(C)C)c2cc(Oc3ncccn3)ccc12.ClCCl.O=C(O)C(F)(F)F>>CC(=O)c1cn(CC(=O)O)c2cc(Oc3ncccn3)ccc12",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)CN.Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccc(Oc2ccc(OCCCC(=O)O)cc2)cc1.Cl.Cl.Cl.O.On1nnc2ccccc21>>COC(=O)CNC(=O)CCCOc1ccc(Oc2ccc(CN(Cc3ccccc3)c3cccc(NS(C)(=O)=O)c3C)cc2)cc1",
        "output": "129"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CCc1ccc2c(-c3cnc4c(n3)c(C(=O)NC(C)(C)C)cn4COCC[Si](C)(C)C)nn(C)c2c1.CN(C)C=O.NCCN.[F-]>>CCc1ccc2c(-c3cnc4[nH]cc(C(=O)NC(C)(C)C)c4n3)nn(C)c2c1",
        "output": "981"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Br.COc1ccc(C2CCCN2CCN2CCOCC2)cc1.O=C([O-])O.[Na+]>>Oc1ccc(C2CCCN2CCN2CCOCC2)cc1",
        "output": "207"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Nc1cccc(-n2c(=O)c(Cc3cccnc3)nc3cccnc32)c1.Cl.O=C([O-])O.[Na+]>>Nc1cccc(-n2c(=O)c(Cc3cccnc3)nc3cccnc32)c1",
        "output": "66"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1CCN(C2CN(C(=O)OCc3ccccc3)C2)CC1.CO.[Pd]>>CN1CCN(C2CNC2)CC1",
        "output": "428"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCNCC.Nc1cc(F)c([N+](=O)[O-])cc1[N+](=O)[O-].O>>CCN(CC)c1cc(N)c([N+](=O)[O-])cc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NCc1ccncc1.O=C(O)c1ccc2cncc(Br)c2n1>>O=C(NCc1ccncc1)c1ccc2cncc(Br)c2n1",
        "output": "137"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C=Cc1ccc(NC2=CC3=NCN(C)C3=CC2(F)C(=O)OC)c(F)c1.[Pd]>>CCc1ccc(NC2=CC3=NCN(C)C3=CC2(F)C(=O)OC)c(F)c1",
        "output": "555"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=[N+]([O-])c1cnccc1Oc1ccc2[nH]ccc2c1.[Pd]>>Nc1cnccc1Oc1ccc2[nH]ccc2c1",
        "output": "269"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.N.N#Cc1cc(Cl)ccc1-n1cnnn1.[Ni]>>NCc1cc(Cl)ccc1-n1cnnn1",
        "output": "175"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CNCCCN.O=Cc1cc(Cl)cc(Cl)c1O>>CNCCCN=Cc1cc(Cl)cc(Cl)c1O",
        "output": "52"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCCCC1C(=O)O.COC(=O)c1ccc([C@H](C)N)cc1.Cl>>COC(=O)c1ccc([C@H](C)NC(=O)C2CCCCN2C(=O)OC(C)(C)C)cc1",
        "output": "797"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCC(C)N(C)C.CN(C)C=O.CNCc1cccc2ccccc12.COc1cc(O)c2c(c1C(=O)O)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C.Cl.O.On1nnc2ccccc21.[Cl-].[NH4+]>>COc1cc(O)c2c(c1C(=O)N(C)Cc1cccc3ccccc13)OC1=CC(O)=C(C(C)=O)C(=O)[C@]12C",
        "output": "794"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CCCNC1.CCN(C(C)C)C(C)C.CN1CCCC1=O.NC(=O)c1ccc(Cl)nc1Nc1ccc(C(=O)N2CCOCC2)cc1.O>>CC(C)(C)OC(=O)N[C@@H]1CCCN(c2ccc(C(N)=O)c(Nc3ccc(C(=O)N4CCOCC4)cc3)n2)C1",
        "output": "220"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.COc1cc(O)c2cc(-c3cn4nc(OC)sc4n3)oc2c1.OCc1cccc(OCc2ccccc2)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc(OCc2cccc(OCc3ccccc3)c2)c2cc(-c3cn4nc(OC)sc4n3)oc2c1",
        "output": "347"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C1(c2ccccc2)CCC2(CCNCC2)CC1.c1ccc(C2(N3CCCC3)CCC3(CC2)OCCO3)cc1>>O=C1CCC(c2ccccc2)(N2CCCC2)CC1",
        "output": "251"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CCOc1ccc([N+](=O)[O-])c(/C=C/c2n[nH]c3ccccc23)c1.CCO.Cl.[Sn]>>CCN(CC)CCOc1ccc(N)c(/C=C/c2n[nH]c3ccccc23)c1",
        "output": "202"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)NC(C)C.CCN(CC)CC.CCOC(=O)Cl.O=C(O)c1cc2ccccc2c(-c2ccccc2Cl)n1>>CC(C)N(C(=O)c1cc2ccccc2c(-c2ccccc2Cl)n1)C(C)C",
        "output": "605"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.ClCCOCCCl.Nc1cc(Cl)c(N)c(C(F)(F)F)c1.[I-].[Na+]>>Nc1c(Cl)cc(N2CCOCC2)cc1C(F)(F)F",
        "output": "640"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1c(F)cc(Br)cc1F.OB(O)c1ccc2c(c1)CCO2>>Nc1c(F)cc(-c2ccc3c(c2)CCO3)cc1F",
        "output": "837"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.Cn1cc(CO)c(C(F)(F)F)n1.Oc1cc(-c2cnnc(-c3ccccc3)c2)ccc1F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cn1cc(COc2cc(-c3cnnc(-c4ccccc4)c3)ccc2F)c(C(F)(F)F)n1",
        "output": "550"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrC(Br)(Br)Br.CC#N.CCCCCCCC/C=C\\CCCCCCCCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCCCCCC/C=C\\CCCCCCCCBr",
        "output": "378"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccc2c(c1)CCN2C(C)=O.COC(OC)N(C)C>>CC(=O)N1CCc2cc(C(=O)/C=C/N(C)C)ccc21",
        "output": "898"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1nc2sccn2c1C(=O)NC[C@H]1NC[C@H]2C[C@H]21.O=S(=O)(Cl)c1ccccc1OC(F)(F)F>>Cc1nc2sccn2c1C(=O)NC[C@@H]1[C@@H]2C[C@@H]2CN1S(=O)(=O)c1ccccc1OC(F)(F)F",
        "output": "99"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(Cc1nc2ccccc2n1C[C@H]1CCCNC1)[C@H]1CCCc2cccnc21.ClCCCl.[Na+]>>CN1CCC[C@H](Cn2c(CN(C)[C@H]3CCCc4cccnc43)nc3ccccc32)C1",
        "output": "217"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)N(CC#N)C(=O)CO4)cc2)CCC1.NC1(c2ccc(-c3nc4c(cc3-c3ccccc3)C(=O)CCC4)cc2)CCC1>>N#CCN1C(=O)COc2nc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)cc21",
        "output": "793"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.COc1cc(F)ccc1-c1ccc2c(c1CO)NC(=O)C(C)(C)N2.CS(=O)(=O)Cl.ClCCl.O>>COc1cc(F)ccc1-c1ccc2c(c1CCl)NC(=O)C(C)(C)N2",
        "output": "713"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc2nccc(Oc3ccc4c(C(=O)O)cccc4c3)c2cc1OC.NCc1ccc(C(=O)Nc2ccccc2N)cc1>>COc1cc2nccc(Oc3ccc4c(C(=O)NCc5ccc(C(=O)Nc6ccccc6N)cc5)cccc4c3)c2cc1OC",
        "output": "753"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "NCCCNc1ccc2ccccc2n1.O=Cc1cccs1>>c1csc(CNCCCNc2ccc3ccccc3n2)c1",
        "output": "691"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CC(=O)NC(C)Cc1ccc(C#Cc2ccc(C(=O)O)cc2)cc1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F>>CC(=O)NC(C)Cc1ccc(C#Cc2ccc(C(=O)N3CCCCC3)cc2)cc1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)OB(c2ccc(F)cc2C#N)OC1(C)C.Cc1c(Br)cccc1[N+](=O)[O-]>>Cc1c(-c2ccc(F)cc2C#N)cccc1[N+](=O)[O-]",
        "output": "933"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)Oc1ccc(F)cc1C.O=S(=O)(O)O.O=[N+]([O-])O>>COC(=O)Oc1cc([N+](=O)[O-])c(F)cc1C",
        "output": "21"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(Cl)c1cc([N+](=O)[O-])ccc1Cl.[Al+3].[Cl-].[Cl-].[Cl-].c1ccccc1>>O=C(c1ccccc1)c1cc([N+](=O)[O-])ccc1Cl",
        "output": "61"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc(C)c(N)cc1OC.COc1ccc(Nc2nc(Cl)ncc2Cl)c(NS(C)(=O)=O)c1>>COc1ccc(Nc2nc(Nc3cc(OC)c(OC)cc3C)ncc2Cl)c(NS(C)(=O)=O)c1",
        "output": "907"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)N1CCN(C(c2ccc(Cl)cc2)c2ccccc2Cl)CC1.CO.[Na+].[OH-]>>Clc1ccc(C(c2ccccc2Cl)N2CCNCC2)cc1",
        "output": "283"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.COc1ccc(-n2c(-c3c(C)noc3C)cc3ccccc32)cc1.O=C1CCC(=O)N1Br>>COc1ccc(-n2c(-c3c(C)noc3C)c(Br)c3ccccc32)cc1",
        "output": "796"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)c1cn(CC(=O)O)c2ccc(NC(=O)C3CCC(F)(F)C3)cc12.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.F[P-](F)(F)(F)(F)F.O=C(Nc1cccc(-c2ccccc2Cl)c1F)[C@@H]1C[C@@H](F)CN1>>CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(-c3ccccc3Cl)c2F)c2ccc(NC(=O)C3CCC(F)(F)C3)cc12",
        "output": "297"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCCCCCCCO.ClCCl.O=C(O)C1CCN(C(=O)OCc2ccccc2)CC1.c1cc(N2CCCC2)ccn1>>CCCCCCCCOC(=O)C1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "47"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCCCBr.CCCC[N+](CCCC)(CCCC)CCCC.OCCOCc1ccccc1.[Br-].[Na+].[OH-]>>BrCCCCCOCCOCc1ccccc1",
        "output": "95"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(C2(O)CCC(=O)CC2)cn1.Cn1nc(NCC(=O)NC2CNC2)c2cc(C(O)C(F)(F)F)ccc21.O=C(O)C(F)(F)F>>Cc1ccc(C2(O)CCC(N3CC(NC(=O)CNc4nn(C)c5ccc(C(O)C(F)(F)F)cc45)C3)CC2)cn1",
        "output": "187"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CCO.CCOc1ccccc1OCCN(C(=O)OC(C)(C)C)C(C)Cc1cc(C#N)c2c(c1)CCN2C(C)=O.[Na+].[OH-]>>CCOc1ccccc1OCCN(C(=O)OC(C)(C)C)C(C)Cc1cc(C#N)c2c(c1)CCN2",
        "output": "504"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1nc(-c2cccc(N)c2F)c(-c2ccnc(N)n2)s1.O=S(=O)(Cl)c1ccccc1F>>CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3ccccc3F)c2F)c(-c2ccnc(N)n2)s1",
        "output": "68"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCCCC1.ClCCl.Cn1nc(-c2cnc3c(n2)c(C(=O)NC(C)(C)C)cn3COCC[Si](C)(C)C)c2c1CCCC2.O=C(O)C(F)(F)F>>Cn1nc(-c2cnc3[nH]cc(C(=O)NC(C)(C)C)c3n2)c2c1CCCC2",
        "output": "981"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CN(C)C=O.CN1CCOCC1.COc1ccc2c(c1)c(C(=O)O)c(Cl)n2-c1ccccc1.ClCCCl.On1nnc2cccnc21>>COc1ccc2c(c1)c(C(=O)N1CCN(C(=O)OC(C)(C)C)CC1)c(Cl)n2-c1ccccc1",
        "output": "256"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.Nc1ccccc1.O=C(Nc1cc(CCCO)cc(C(F)(F)F)c1)C(F)(F)F>>O=CCCc1cc(NC(=O)C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COC(=O)CCC1c2ccc(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)cc2CCCN1C(=O)OC(C)(C)C.[Na+].[OH-]>>CC(C)Oc1ccc(-c2nc(-c3ccc4c(c3)CCCN(C(=O)OC(C)(C)C)C4CCC(=O)O)no2)cc1Cl",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)S(=O)(=O)Cl.O=C(NCc1ccn2ccnc2c1)c1ccc(C2CNC2)cc1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.[H-].[Na+]>>CC(C)S(=O)(=O)N1CC(c2ccc(C(=O)NCc3ccn4ccnc4c3)cc2)C1",
        "output": "584"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Br.CC(C)(C)c1cccc(N)c1O.CCOC(C)=O.O.O=C(Cl)C(Cl)c1ccccc1.O=C([O-])O.[Na+]>>CC(C)(C)c1cccc(NC(=O)C(Cl)c2ccccc2)c1O",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc(C(=O)N2[C@@H](c3cnc(Cl)s3)[C@@H](c3cnccn3)C[C@@]2(CC(C)C)C(=O)OC(C)(C)C)ccc1C(C)(C)C.O=C(O)C(F)(F)F>>COc1cc(C(=O)N2[C@@H](c3cnc(Cl)s3)[C@@H](c3cnccn3)C[C@@]2(CC(C)C)C(=O)O)ccc1C(C)(C)C",
        "output": "278"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)CCSc1ccc(CN2CCNC2=N[N+](=O)[O-])cn1.O.[Na+].[OH-]>>O=C(O)CCSc1ccc(CN2CCNC2=N[N+](=O)[O-])cn1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)Nc1nc2cc(Cl)ccc2nc1OC.Clc1cccc(N2CCNCC2)c1>>COc1nc2ccc(Cl)cc2nc1NC(=O)N1CCN(c2cccc(Cl)c2)CC1",
        "output": "613"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)NCCc1ccc(-c2cccc(O)c2)cc1.CN(C)C=O.Clc1ccnc(Cl)n1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)NCCc1ccc(-c2cccc(Oc3ccnc(Cl)n3)c2)cc1",
        "output": "668"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)Cc1nccn1CCCCc1ccc(O)cc1.Fc1cc(/C=C/c2nc(CCl)co2)ccc1Cl.[H-].[Na+]>>CS(=O)(=O)Cc1nccn1CCCCc1ccc(OCc2coc(/C=C/c3ccc(Cl)c(F)c3)n2)cc1",
        "output": "760"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CNC(=O)c1ccc(Cl)nc1.CS(C)=O.O=C(N1CCCN(C2CCC2)CC1)N1CC(O)C1.[H-].[Na+]>>CNC(=O)c1ccc(OC2CN(C(=O)N3CCCN(C4CCC4)CC3)C2)nc1",
        "output": "433"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCc1cc(F)c(-c2cnc(Cl)nc2)c(F)c1.CCO.Cc1ccccc1.O=C([O-])[O-].OB(O)c1cc(F)cc(F)c1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCCCc1cc(F)c(-c2cnc(-c3cc(F)cc(F)c3)nc2)c(F)c1",
        "output": "874"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CI.CN(C)C=O.O.O=C1NCCN(Cc2ccccc2)C1c1ccccc1.[H-].[Na+]>>CN1CCN(Cc2ccccc2)C(c2ccccc2)C1=O",
        "output": "83"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C=O.COC(=O)CCCCCCC(=O)Cl.Nc1cc(-c2ccccc2)ccc1[N+](=O)[O-]>>COC(=O)CCCCCCC(=O)Nc1cc(-c2ccccc2)ccc1[N+](=O)[O-]",
        "output": "9"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)c1ccn(-c2ccc(C(F)F)cn2)c1.O.O=C(O)C(F)(F)F>>O=C(O)c1ccn(-c2ccc(C(F)F)cn2)c1",
        "output": "569"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C(=O)Cl)c1ccccc1.O=S(=O)(NCCC1CCCCC1)c1ccc(O)cc1>>CN(C(=O)Oc1ccc(S(=O)(=O)NCCC2CCCCC2)cc1)c1ccccc1",
        "output": "425"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CO.Oc1ccc(SCCCNCCC(c2ccccc2)c2ccccc2)cc1>>CN(CCCSc1ccc(O)cc1)CCC(c1ccccc1)c1ccccc1",
        "output": "483"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.Cc1cc2cc(-c3cnn(C4CCCCO4)c3)ccc2n1CC1CNC(C)C1.ClCCl.O=C(Cl)CCc1ccccc1.O=C([O-])O.[Na+]>>Cc1cc2cc(-c3cnn(C4CCCCO4)c3)ccc2n1CC1CC(C)N(C(=O)CCc2ccccc2)C1",
        "output": "125"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCOC(=O)c1cnc(-c2ccc(OC)c(F)c2)c(Cl)c1.O=C([O-])O.O=C1CCC(=O)N1I.O=S(=O)(O)O.[Na+]>>CCOC(=O)c1cnc(-c2cc(F)c(OC)c(I)c2)c(Cl)c1",
        "output": "834"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)I.CCOC(=O)/C(C)=C/c1ccc(O)cc1Oc1ncc(C(F)(F)F)cc1Cl.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)/C(C)=C/c1ccc(OC(C)C)cc1Oc1ncc(C(F)(F)F)cc1Cl",
        "output": "318"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CCC[C@@H](C)O[C@@H](CC)[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)O.C=C[C@@H]1C[C@]1(N)C(=O)NS(=O)(=O)C1(C)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)C(F)(F)F>>C=CCC[C@@H](C)O[C@@H](CC)[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@]1(C(=O)NS(=O)(=O)C2(C)CC2)C[C@H]1C=C",
        "output": "131"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.CCOC(=O)CBr.N#Cc1cc(Cl)ccc1O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)COc1ccc(Cl)cc1C#N",
        "output": "123"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCCCCBr.C=CCOc1ccc(C(=O)Oc2ccc(O)cc2)cc1.CCC(C)=O.O=C([O-])[O-].[K+].[K+]>>C=CCOc1ccc(C(=O)Oc2ccc(OCCCCBr)cc2)cc1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN.Cl.Clc1ccc(C2COCc3c(Cl)nc(Cl)nc32)cc1>>CNc1nc(Cl)nc2c1COCC2c1ccc(Cl)cc1",
        "output": "110"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCOC(C)=O.O.O=C(NCC1(c2cccc(Cl)c2)CCC2(CC1)OCCO2)C(F)(F)F>>O=C1CCC(CNC(=O)C(F)(F)F)(c2cccc(Cl)c2)CC1",
        "output": "251"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1cc(O)ccc1F.[Pd]>>Nc1cc(O)ccc1F",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCN(CCCC)c1ccc(C#C[Si](C)(C)C)cc1.CO.O.[K+].[OH-]>>C#Cc1ccc(N(CCCC)CCCC)cc1",
        "output": "337"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOP(=O)(OCC)C(F)(F)c1cc2nc(C(=O)O)ccc2cc1Br.Cl.ClCCl.Nc1ccccc1>>CCOP(=O)(OCC)C(F)(F)c1cc2nc(C(=O)Nc3ccccc3)ccc2cc1Br",
        "output": "548"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=O.COC(=O)/C=C/c1ccc2c(c1)C(=O)NC1(CCCN(C(=O)OC(C)(C)C)C1)O2.[BH3-]C#N.[Na+]>>COC(=O)/C=C/c1ccc2c(c1)C(=O)NC1(CCCN(C)C1)O2",
        "output": "881"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)Cn1c(C)c(Cc2ccc(=O)n(Cc3ccc(F)c(F)c3)c2)c2ccccc21.O.[Li+].[OH-]>>Cc1c(Cc2ccc(=O)n(Cc3ccc(F)c(F)c3)c2)c2ccccc2n1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.Fc1ccc(-c2ccn(C3CC3)n2)cc1.O.O=C1CCC(=O)N1Br>>Fc1ccc(-c2nn(C3CC3)cc2Br)cc1",
        "output": "620"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CCN(c2ccnc(Cl)n2)C1.CC(C)CN.CC(C)O.CCN(C(C)C)C(C)C>>CC(C)CNc1nccc(N2CC[C@@H](NC(=O)OC(C)(C)C)C2)n1",
        "output": "544"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)O.O=C(c1ccc([N+](=O)[O-])o1)N1CCNCC1.O=Cc1ccc(F)cc1>>O=C(c1ccc([N+](=O)[O-])o1)N1CCN(Cc2ccc(F)cc2)CC1",
        "output": "567"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.FC(F)(F)c1ccc(OC2CCN(Cc3ccccc3)CC2)cc1.[H][H].[Pd]>>FC(F)(F)c1ccc(OC2CCNCC2)cc1",
        "output": "84"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCOc1ccc(Cn2c(C)nc3ccc(O)cc32)c(Cl)c1.CCOC(=O)CBr.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCCCCOc1ccc(Cn2c(C)nc3ccc(OCC(=O)OCC)cc32)c(Cl)c1",
        "output": "123"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc(CN(C(=O)CN2C(=O)N[C@]3(CCc4ccccc43)C2=O)[C@@H](C)C2CC2)cnc1NC(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>COc1cc(CN(C(=O)CN2C(=O)N[C@]3(CCc4ccccc43)C2=O)[C@@H](C)C2CC2)cnc1N",
        "output": "885"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClCCl.Nc1cc(Br)cnc1Cl>>CC(=O)Nc1cc(Br)cnc1Cl",
        "output": "422"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C1=Cc2ccc(Cc3ccc(C)cc3C)cc2OC1C(F)(F)F.[Li+].[OH-]>>Cc1ccc(Cc2ccc3c(c2)OC(C(F)(F)F)C(C(=O)O)=C3)c(C)c1",
        "output": "122"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCN(C(C)C)C(C)C.FCCBr.NC1CCC(Nc2ncnc3sc4c(c23)CCC4)CC1>>FCCNC1CCC(Nc2ncnc3sc4c(c23)CCC4)CC1",
        "output": "147"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccc(CCOC3CCCCO3)cn2)n1.ClCCl.O=C(O)C(F)(F)F>>CC(c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccc(CCO)cn2)n1",
        "output": "543"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCNS(=O)(=O)c1c(Cl)ccc([N+](=O)[O-])c1O.[H][H].[Pd]>>CC(C)(C)OC(=O)NCCNS(=O)(=O)c1c(Cl)ccc(N)c1O",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)c1ccc(C(=O)Cl)cc1.Nc1ccc(Nc2cc(-c3cccc4c3oc3ccccc34)ncn2)cc1.O=C(O)C(F)(F)F.c1ccncc1>>CN(C)c1ccc(C(=O)Nc2ccc(Nc3cc(-c4cccc5c4oc4ccccc45)ncn3)cc2)cc1",
        "output": "11"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1=C(C(=O)O)C(c2ccc3ccccc3c2)CC(=O)N1.CN(C)C=O.Nc1ccc2[nH]ncc2c1>>CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc3ccccc3c2)CC(=O)N1",
        "output": "170"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)[O-].COC(=O)CCc1c(C)[nH]c2ccc(F)cc12.O=C(Cl)c1ccc(Cl)cc1.[Cl-].[NH4+].[Na+]>>COC(=O)CCc1c(C)n(C(=O)c2ccc(Cl)cc2)c2ccc(F)cc12",
        "output": "232"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCO.Cc1ccc(S(=O)(=O)O)cc1.O=C(CBr)c1ccc2ccccc2c1.OCCO.c1ccccc1>>BrCC1(c2ccc3ccccc3c2)OCCO1",
        "output": "93"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1cc([N+](=O)[O-])ccc1S.O=C([O-])[O-].OCC(CO)(CO)CBr.[K+].[K+]>>COc1cc([N+](=O)[O-])ccc1SCC(CO)(CO)CO",
        "output": "124"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.CCOCCO.Cc1ccc2cc(Br)ccc2n1.ClCCl.O.O=C([O-])O.OB(O)c1cccc2ccccc12.[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1ccc2cc(-c3cccc4ccccc34)ccc2n1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCOc1cc(CCC(=O)OC)ccc1-c1cccc(CN(C)C(=O)c2cccc(OC)c2)c1.CO.[Na+].[OH-]>>CCCCOc1cc(CCC(=O)O)ccc1-c1cccc(CN(C)C(=O)c2cccc(OC)c2)c1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(C)=O.Cl.Cn1nc(C(F)(F)F)cc1-c1cnc(NC(=O)c2c(F)cccc2F)s1>>Cn1nc(C(F)(F)F)cc1-c1cnc(NCc2c(F)cccc2F)s1",
        "output": "215"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCc1cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3OC)nc2n(-c2cccc(NC(=O)OC(C)(C)C)c2)c1=O.ClCCl.O=C(O)C(F)(F)F>>CCc1cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3OC)nc2n(-c2cccc(N)c2)c1=O",
        "output": "782"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.Cl.O=C([O-])[O-].O=[N+]([O-])c1ccc(-n2ccnc2-c2ccncc2)cc1.[Fe].[Na+].[Na+]>>Nc1ccc(-n2ccnc2-c2ccncc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(Cc1ccc(F)cc1)C1CCCCC1[N+](=O)[O-].CO.O.[Ni]>>CN(Cc1ccc(F)cc1)C1CCCCC1N",
        "output": "226"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#Cc1cccc(O)c1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.CN1CCC(O)CC1.Cl.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C#Cc1cccc(OC2CCN(C)CC2)c1",
        "output": "550"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCOc1nc(N(CC)Cc2cc(Br)ccc2OCc2ccccc2)ccc1C(=O)O.CCOC(C)=O.CN(C)C(OC(C)(C)C)OC(C)(C)C.Cc1ccccc1>>C=CCOc1nc(N(CC)Cc2cc(Br)ccc2OCc2ccccc2)ccc1C(=O)OC(C)(C)C",
        "output": "768"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)C[C@@H]1COc2cc(OCc3cccc(-c4c(C)cc(OCCCS(C)(=O)=O)cc4C)c3)ccc21.Cl.O.[Na+].[OH-]>>Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CI.CN(C)C=O.O=C([O-])[O-].O=C1Cc2cccc3ccc(O)c1c23.[K+].[K+]>>COc1ccc2cccc3c2c1C(=O)C3",
        "output": "62"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)c1cccc(Oc2ccc(F)cc2[N+](=O)[O-])c1.Cl.O.O.O.[Li+].[OH-]>>O=C(O)c1cccc(Oc2ccc(F)cc2[N+](=O)[O-])c1",
        "output": "5"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(=O)OCc1nc2ccc(F)cn2c(=O)c1Br.Cl.O.[NH4+].[OH-]>>O=c1c(Br)c(CO)nc2ccc(F)cn12",
        "output": "348"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(O)cc1.O=[N+]([O-])c1ccc(Br)cc1.[Cu].[K+].[OH-]>>COc1ccc(Oc2ccc([N+](=O)[O-])cc2)cc1",
        "output": "238"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.COCC(=O)c1ccc(O)cc1.CS(=O)(=O)OCCCOc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl.O.O=C([O-])[O-].[K+].[K+]>>COCC(=O)c1ccc(OCCCOc2c(Cl)cc(OCC=C(Cl)Cl)cc2Cl)cc1",
        "output": "702"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)NC(=O)CC1CCC(c2ncc(-c3ccc(N)cc3)s2)CC1.COC(=O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1.O=C=Nc1ccc(F)cc1F>>CC(=O)NC(=O)CC1CCC(c2ncc(-c3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)s2)CC1",
        "output": "473"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CC(=O)c1ccc(OCCCCl)cc1F.CCOCC.O=C([O-])O.[Na+]>>O=C(CBr)c1ccc(OCCCCl)cc1F",
        "output": "173"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCOC(=O)CC1CCc2c1[nH]c1ccc(OCc3ccc(C(F)(F)F)cc3C(F)(F)F)cc21.O.[Na+].[OH-]>>O=C(O)CC1CCc2c1[nH]c1ccc(OCc3ccc(C(F)(F)F)cc3C(F)(F)F)cc21",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)c1ccccc1N1CCNCC1.CCN(C(C)C)C(C)C.Cl.Cl.ClCCl.O=C(Cl)c1ccc(F)cc1>>CC(C)(C)c1ccccc1N1CCN(C(=O)c2ccc(F)cc2)CC1",
        "output": "201"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.Cl.Cl.O.O=C(NCC(F)(F)F)C1(CCCCBr)c2ccccc2-c2ccccc21.O=C([O-])[O-].[K+].[K+].c1ccc(-c2cccc(N3CCNCC3)c2)cc1>>O=C(NCC(F)(F)F)C1(CCCCN2CCN(c3cccc(-c4ccccc4)c3)CC2)c2ccccc2-c2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)Cc1cc(COCC(F)(F)F)nc(Nc2ccc(-n3cnc(C)c3)c(OC)c2)n1.O.[C-]#N.[K+].[NH4+].[OH-]>>COc1cc(Nc2nc(COCC(F)(F)F)cc(CC(N)=O)n2)ccc1-n1cnc(C)c1",
        "output": "163"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1ccc(C(=O)O)cc1Cl.CI.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(C(C)=O)c(Cl)c1",
        "output": "415"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.COCCOC.Cc1ccc(-c2c(Cl)ncnc2NS(=O)(=O)C=Cc2ccccc2)cc1.OCCO.[Na]>>Cc1ccc(-c2c(NS(=O)(=O)C=Cc3ccccc3)ncnc2OCCO)cc1",
        "output": "653"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC(CC1(C(=O)Nc2nnc(CC)s2)CCCC1)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CCCC(CC1(C(=O)Nc2nnc(CC)s2)CCCC1)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCI.CN(C)C=O.Cc1cc(C(=O)O)ccc1[N+](=O)[O-].O.O=C([O-])O.[Na+]>>CCOC(=O)c1ccc([N+](=O)[O-])c(C)c1",
        "output": "196"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CI.COc1ccccc1C(=O)N1CCC2(CC1)CC(O)c1ccccc1O2.[H-].[Na+]>>COc1ccccc1C(=O)N1CCC2(CC1)CC(OC)c1ccccc1O2",
        "output": "140"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(C(=O)OCc2ccccc2)CC3)cc1.[Pd]>>Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCNCC3)cc1",
        "output": "428"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(C=O)ccc1OCc1ccccc1.O.O=[Ag].[Na+].[OH-]>>COc1cc(C(=O)O)ccc1OCc1ccccc1",
        "output": "384"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCNC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O.O=C(O)c1ccc(B(O)O)cc1F.[Cl-].[NH4+]>>CCN(C)C(=O)c1ccc(B(O)O)cc1F",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.C=CCN(CCNC(=O)C1CCN(c2ccc(=O)n(C)n2)CC1)S(=O)(=O)c1ccc2c(Cl)cn(S(=O)(=O)c3ccccc3)c2c1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>C=CCN(CCNC(=O)C1CCN(c2ccc(=O)n(C)n2)CC1)S(=O)(=O)c1ccc2c(Cl)c[nH]c2c1",
        "output": "771"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C1CSC(=O)N1.O=Cc1ccccc1.[Mn+4].[O-2].[O-2]>>O=C1NC(=O)C(=Cc2ccccc2)S1",
        "output": "761"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC[C@@H](CC(O)c1cc(F)cc(C#N)c1)O[Si](C)(C)C(C)(C)C.CS(=O)(=O)Cl.ClCCl.O>>CC(C)(C)OC(=O)NC[C@@H](CC(OS(C)(=O)=O)c1cc(F)cc(C#N)c1)O[Si](C)(C)C(C)(C)C",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1C(O)C(F)(F)F.N#Cc1ccc(CBr)cc1F.O.[H-].[Na+]>>Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1C(OCc1ccc(C#N)c(F)c1)C(F)(F)F",
        "output": "464"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CN(C)C=O.NN.O.O=C1c2ccccc2C(=O)N1Cc1ccc(Cl)nc1Cl>>NCc1ccc(Cl)nc1Cl",
        "output": "242"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.O=C(Nc1nccs1)C(CC1CCCC1)c1ccc([N+](=O)[O-])cc1.[Pd]>>Nc1ccc(C(CC2CCCC2)C(=O)Nc2nccs2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.Cl.O=C1CCCN(C(=O)c2ccc([N+](=O)[O-])cc2)c2ccsc21.[Fe]>>Nc1ccc(C(=O)N2CCCC(=O)c3sccc32)cc1",
        "output": "28"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.CS(=O)(=O)c1ccc(Oc2ncnc3c2cnn3C2CCNCC2)cc1.ClCCCl.O=C(O)C(F)(F)F.O=Cc1cccc(Cl)c1.[Na+]>>CS(=O)(=O)c1ccc(Oc2ncnc3c2cnn3C2CCN(Cc3cccc(Cl)c3)CC2)cc1",
        "output": "567"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.Cl.O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)NCc1cccc(C(=O)Nc2ccc(C3OCCO3)cc2)c1.O=C([O-])O.[Na+]>>O=Cc1ccc(NC(=O)c2cccc(CNC(=O)CCN3CCC(OC(=O)Nc4ccccc4-c4ccccc4)CC3)c2)cc1",
        "output": "655"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1nc2c3c(nn2c(C)c1Cl)CN(C(=O)c1ccccc1OC[C@H]1CCCN1C(=O)OC(C)(C)C)C3.Cl.ClCCl>>Cc1nc2c3c(nn2c(C)c1Cl)CN(C(=O)c1ccccc1OC[C@H]1CCCN1)C3",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=Cc1ccc(Oc2cccc(C(F)(F)F)c2)cc1.[BH4-].[Na+]>>OCc1ccc(Oc2cccc(C(F)(F)F)c2)cc1",
        "output": "356"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CN1CC[C@@H](N)C1.CCOC(C)=O.Cl.Cl.O=S(=O)(Cl)c1ccc(Cl)s1>>CCOC(=O)CN1CC[C@@H](NS(=O)(=O)c2ccc(Cl)s2)C1",
        "output": "600"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)NCCCO.CCN(CC)CC.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)NCCC=O",
        "output": "142"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.CCN(CC)CC.Cl.Cl.ClCCl.O=S(=O)(c1ccccc1)n1cc(-c2ccc3cn(CC4CCNCC4)nc3c2)c2ccc(F)cc21.O=S(=O)(c1ccccc1)n1cc(-c2ccc3cnn(CC4CCNCC4)c3c2)c2ccc(F)cc21>>CC(=O)N1CCC(Cn2ncc3ccc(-c4cn(S(=O)(=O)c5ccccc5)c5cc(F)ccc45)cc32)CC1",
        "output": "125"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.O=[N+]([O-])c1cccc(-n2ccnn2)c1.[H][H].[Pd]>>Nc1cccc(-n2ccnn2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1cnc2[nH]ccc2c1.C1CCOC1.CCOC(C)=O.Cl[Pd]Cl.O.O=Cc1cccc(B(O)O)c1.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=Cc1cccc(-c2cnc3[nH]ccc3c2)c1",
        "output": "833"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)COc1ccc(CC(=O)OCc2ccccc2)cc1.[OH-].[OH-].[Pd+2]>>COC(=O)COc1ccc(CC(=O)O)cc1",
        "output": "186"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1c(F)c(F)c(-c2ccc(C(C)(C)O[SiH2]C(C)(C)C)cc2)c(F)c1F.[Na+].[OH-]>>CC(C)(C)[SiH2]OC(C)(C)c1ccc(-c2c(F)c(F)c(C(=O)O)c(F)c2F)cc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1CCC(N)CC1.CCCCCC.CN(C)C=O.CN1CCOCC1.ClCCl.O=C(O)c1ccc(C(c2cc(F)ccc2F)S(=O)(=O)c2ccc(Cl)cc2)nc1.O=S(Cl)Cl>>CC1CCC(NC(=O)c2ccc(C(c3cc(F)ccc3F)S(=O)(=O)c3ccc(Cl)cc3)nc2)CC1",
        "output": "674"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCCOC(=O)Cl.Nc1ccc(-c2nc(Cl)c([C@@H]3CCc4cc(-c5cc(Cl)ccc5-n5cnnn5)cc(=O)n43)[nH]2)cc1>>COCCOC(=O)Nc1ccc(-c2nc(Cl)c([C@@H]3CCc4cc(-c5cc(Cl)ccc5-n5cnnn5)cc(=O)n43)[nH]2)cc1",
        "output": "102"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1NCCc2ccc(-c3ccoc3)cc21.O=C(O)c1cc2ncc(Br)cn2n1>>CC1c2cc(-c3ccoc3)ccc2CCN1C(=O)c1cc2ncc(Br)cn2n1",
        "output": "952"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(-c2cn(-c3ccnc(SC)n3)c3cc(-c4cccc([N+](=O)[O-])c4)ccc23)cc1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.[Na+]>>COc1ccc(-c2cn(-c3ccnc(S(C)=O)n3)c3cc(-c4cccc([N+](=O)[O-])c4)ccc23)cc1",
        "output": "595"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Oc1c(Cl)ccc(C=O)c1F.CO.[Na+].[OH-]>>O=Cc1ccc(Cl)c(O)c1F",
        "output": "22"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(CC)(c1ccc(CCC(O[Si](C)(C)C(C)(C)C)C(C)(C)C)c(C)c1)c1ccc(OS(=O)(=O)C(F)(F)F)c(C)c1.ClCCl.O=C(O)C(F)(F)F>>CCC(CC)(c1ccc(CCC(O)C(C)(C)C)c(C)c1)c1ccc(OS(=O)(=O)C(F)(F)F)c(C)c1",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](CN)C1.CCN(C(C)C)C(C)C.CS(C)=O.O=[N+]([O-])c1ccc(C(F)(F)F)cc1Cl>>CC(C)(C)OC(=O)N1CC[C@@H](CNc2cc(C(F)(F)F)ccc2[N+](=O)[O-])C1",
        "output": "304"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "O=Cc1ccc(Oc2ccc(C(=O)NC3CC3)cc2)nc1.S=C1OC[C@@H](c2ccccc2)N1C1CCNCC1>>O=C(NC1CC1)c1ccc(Oc2ccc(CN3CCC(N4C(=S)OC[C@H]4c4ccccc4)CC3)cn2)cc1",
        "output": "757"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].N#Cc1ccc2c(c1)OCCC2=O.[BH3-]C#N.[NH4+].[Na+]>>N#Cc1ccc2c(c1)OCCC2N",
        "output": "552"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.C[C@H](O)CN.Cc1nc2c3c(c(C(=O)O)cc2n1C)CCC1(Cc2ccccc2C1)N3.F[B-](F)(F)F>>Cc1nc2c3c(c(C(=O)NC[C@H](C)O)cc2n1C)CCC1(Cc2ccccc2C1)N3",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cccc(-c2cc(S(=O)(=O)Nc3ccc(C(=O)O)c(O)c3)sc2Cl)c1F.OCCCO>>COc1cccc(-c2cc(S(=O)(=O)Nc3ccc(C(=O)OCCCO)c(O)c3)sc2Cl)c1F",
        "output": "47"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)C1CCN(Cc2ccccc2)C1.[OH-].[OH-].[Pd+2]>>CCOC(=O)C1CCNC1",
        "output": "84"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.ClCCl.OCCOCCOCCOCCO>>Cc1ccc(S(=O)(=O)OCCOCCOCCOCCO)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CCc1ccc(CBr)cc1.CN(C)C=O.O=C([O-])[O-].O=c1ccc(Br)c[nH]1.[K+].[K+]>>CCc1ccc(Cn2cc(Br)ccc2=O)cc1",
        "output": "528"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCCC.CCOc1cccc(C(C)(C)O)c1.CI.[H-].[Na+]>>CCOc1cccc(C(C)(C)OC)c1",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.Nc1cc(-c2cnco2)cc(-c2cnco2)c1.O=C(Cl)Oc1ccccc1.c1ccncc1>>O=C(Nc1cc(-c2cnco2)cc(-c2cnco2)c1)Oc1ccccc1",
        "output": "102"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.C[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1.Cl.[Na+].[OH-]>>C[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCN(CC)CC.NC1C2C=CC(C2)C1C(=O)O.O.O=S(=O)(Cl)c1ccc(OCc2ccccc2)cc1>>O=C(O)C1C2C=CC(C2)C1NS(=O)(=O)c1ccc(OCc2ccccc2)cc1",
        "output": "43"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.N#Cc1cnc2c(sc3ccc([N+](=O)[O-])cc32)c1Nc1cccc(Br)c1.O.[Cl-].[Fe].[NH4+]>>N#Cc1cnc2c(sc3ccc(N)cc32)c1Nc1cccc(Br)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(Nc2nn(-c3cccc(C(F)(F)F)c3)c(=O)[nH]2)cc1.CO.O.[Li+].[OH-]>>O=C(O)c1ccc(Nc2nn(-c3cccc(C(F)(F)F)c3)c(=O)[nH]2)cc1",
        "output": "5"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C[C@H](N)c1ccc(F)cn1.Cl.N#Cc1cnc(Nc2cc(Cl)nc(Cl)n2)s1>>C[C@H](Nc1nc(Cl)cc(Nc2ncc(C#N)s2)n1)c1ccc(F)cn1",
        "output": "544"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CC(n2cc(-c3ccc4ncc(Cc5cc6cccnc6cc5F)n4n3)cn2)C1.CCOC(C)=O.Cl.O=C([O-])O.[Na+]>>Fc1cc2ncccc2cc1Cc1cnc2ccc(-c3cnn(C4CNC4)c3)nn12",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CI.Cc1cc(F)cc(I)c1C(=O)O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1c(C)cc(F)cc1I",
        "output": "415"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1[nH]nc(C(C)=O)c1Cl.O.O=S(=O)([O-])O.[K+].[Li+].[OH-]>>CC(=O)c1n[nH]c(C(=O)O)c1Cl",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(=O)[nH]c2ccc(O)cc12.O=S(CCCCBr)c1ccccc1>>Cc1cc(=O)[nH]c2ccc(OCCCCS(=O)c3ccccc3)cc12",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CN(C)C=O.Cc1ccc(S(=O)(=O)OCCCF)cc1.Cl.O.O=C([O-])[O-].O=Cc1ccc(O)c(O)c1.[K+].[K+]>>O=Cc1ccc(OCCCF)c(O)c1",
        "output": "438"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)Cc1ccc(C(C)C(=O)O)cc1.CO.O=S(=O)(O)O>>COC(=O)C(C)c1ccc(CC(C)C)cc1",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(C)=O.CCOC(=O)CBr.O=C([O-])[O-].Oc1ccc2[nH]ccc2c1.[K+].[K+]>>CCOC(=O)COc1ccc2[nH]ccc2c1",
        "output": "123"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOCC.CN(C)c1ccncc1.C[Si](C)(C)CCOCCl.ClCCl.N#Cc1ccc(O)cc1>>C[Si](C)(C)CCOCOc1ccc(C#N)cc1",
        "output": "375"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCc1ccc(Cl)c(F)c1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)NCc1ccc(Cl)c(F)c1",
        "output": "686"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COC(=O)c1cc([N+](=O)[O-])ccc1Cl>>COC(=O)c1cc(N)ccc1Cl",
        "output": "481"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CN1CCCC1CCN1C(=O)COc2cc(N)ccc21.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CN1CCCC1CCN1CCOc2cc(N)ccc21",
        "output": "363"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCN(CC1CC1)c1cc(C(=O)O)ncn1.CCN(C(C)C)C(C)C.COC(=O)Cl.ClCCl.Nc1ccc(N2CCOCC2)c(F)c1>>CCCN(CC1CC1)c1cc(C(=O)Nc2ccc(N3CCOCC3)c(F)c2)ncn1",
        "output": "548"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(N)c1cccc2ccccc12.O=C(O)Cn1cc(-c2ccc(Cl)cc2Cl)nc1C=C1c2ccccc2-c2ccccc21>>CC(NC(=O)Cn1cc(-c2ccc(Cl)cc2Cl)nc1C=C1c2ccccc2-c2ccccc21)c1cccc2ccccc12",
        "output": "599"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)CC(c1ccc(C(F)(F)F)cc1)c1c[nH]c2c(CSC)cccc12.O>>CCOC(=O)CC(c1ccc(C(F)(F)F)cc1)c1cn(C(=O)OC(C)(C)C)c2c(CSC)cccc12",
        "output": "748"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.C[C@@H](OCc1ccccc1)[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.OC1CCCCC1>>C[C@@H](OCc1ccccc1)[C@H](NC(=O)OC(C)(C)C)C(=O)OC1CCCCC1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.CCc1c2n(c3ccccc13)C(=O)C(C(O)c1ncn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c1C)CC2.c1ccncc1>>CCc1c2n(c3ccccc13)C(=O)C(C(OC(C)=O)c1ncn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c1C)CC2",
        "output": "254"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCOCCOCCOCCN1.CCC(C)(C)C(=O)Cl>>CCC(C)(C)C(=O)N1CCOCCOCCOCCOCC1",
        "output": "125"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2ccccc2C)c([N+](=O)[O-])c1.O.[Li+].[OH-]>>Cc1ccccc1-c1ccc(C(=O)O)cc1[N+](=O)[O-]",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CS(=O)(=O)Cl.ClCCl.[N-]=[N+]=NC1CCN(C(=O)OCc2ccccc2)CC1O>>CS(=O)(=O)OC1CN(C(=O)OCc2ccccc2)CCC1N=[N+]=[N-]",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CC(C)O.CCN(C(C)C)C(C)C.CS(=O)(=O)N1CCOc2ccc(CBr)cc21>>CC(C)(C)OC(=O)N1CCN(Cc2ccc3c(c2)N(S(C)(=O)=O)CCO3)CC1",
        "output": "248"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.Clc1nc(Cl)nc(Cl)n1.Nc1ccnc(C(F)(F)F)c1.O=C([O-])O.[Na+]>>FC(F)(F)c1cc(Nc2nc(Cl)nc(Cl)n2)ccn1",
        "output": "592"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1ccc(C2CC(N)CN(C(=O)C3CCCC3)C2)cc1.O=C(O)C(F)(F)F.O=C(O)c1ccccc1>>CCc1ccc(C2CC(NC(=O)c3ccccc3)CN(C(=O)C3CCCC3)C2)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1CCCC(C)N1CCN.CN=C=S>>CNC(=S)NCCN1C(C)CCCC1C",
        "output": "79"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Nc1cc(N(C)C)c([N+](=O)[O-])cc1C(=O)O.CC(=O)O.Cl.O.[Na+].[OH-]>>CN(C)c1cc(N)c(C(=O)O)cc1[N+](=O)[O-]",
        "output": "66"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1CCN(c2ccc(Br)cc2)CC1.Nc1nc2c(-c3ccc(C(F)(F)F)cc3)cccn2n1.c1ccc(P(C2CCCCC2)C2CCCCC2)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c1>>CN1CCN(c2ccc(Nc3nc4c(-c5ccc(C(F)(F)F)cc5)cccn4n3)cc2)CC1",
        "output": "970"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1cccnc1Cl.O=C(Cl)c1ccccc1.c1ccncc1>>O=C(Nc1cccnc1Cl)c1ccccc1",
        "output": "501"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc2nc(N)sc2c1.O.O=C([O-])[O-].[Na+].[Na+].[O-][Br+2]([O-])O>>Nc1nc2ccc(O)cc2s1",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=S(=O)(O)O.O=[N+]([O-])O.O=c1[nH]ccnc1-c1ccccc1>>O=c1[nH]ccnc1-c1ccc([N+](=O)[O-])cc1",
        "output": "21"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(OC)ccc1N(C)c1c(-c2ccccc2)c(C)nn1-c1ccccc1C.O.[Li+].[OH-]>>COc1ccc(N(C)c2c(-c3ccccc3)c(C)nn2-c2ccccc2C)c(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.COc1cc(OC)nc(N2CCNCC2)n1.COc1ccc2[nH]cc(CCCCOS(=O)(=O)c3ccc(C)cc3)c2c1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>COc1ccc2[nH]cc(CCCCN3CCN(c4nc(OC)cc(OC)n4)CC3)c2c1",
        "output": "429"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cl.FC(F)(F)c1ccc(Cl)c(Cl)c1.Nc1cc(F)c(S)cc1F.O.O=C([O-])[O-].[K+].[K+]>>Nc1cc(F)c(Sc2ccc(C(F)(F)F)cc2Cl)cc1F",
        "output": "233"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "B#B.C1CCOC1.COc1ccc(CCCC(=O)O)cc1>>COc1ccc(CCCCO)cc1",
        "output": "231"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1=COCCC1.CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.Cc1cc(OC2CCCCO2)cc(CO)c1Br.ClCCl>>Cc1cc(OC2CCCCO2)cc(COC2CCCCO2)c1Br",
        "output": "306"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)OC(=O)N1CCC(ON=C2CCN(c3cc(F)c(CO)cc3F)CC2)CC1.CI.CN(C)C=O.CO.COC(C)(C)C.[H-].[Na+]>>COCc1cc(F)c(N2CCC(=NOC3CCN(C(=O)OC(C)C)CC3)CC2)cc1F",
        "output": "140"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CNCCOc1ccccc1.Clc1nccnc1Cl>>CN(CCOc1ccccc1)c1nccnc1Cl",
        "output": "505"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COC(=O)C(OC1CCCCC1)c1ccc(Cl)c(Cl)c1.O.[K+].[OH-]>>O=C(O)C(OC1CCCCC1)c1ccc(Cl)c(Cl)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCN(c2cccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(=O)O)n3)c2)CC1.F[P-](F)(F)(F)(F)F>>CNC(=O)Cc1ccccc1CCc1nc(Nc2cccc(N3CCN(C)CC3)c2)ncc1C(F)(F)F",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCS(=O)(=O)c1cc(F)cc(F)c1.Cc1cc(O)ccc1-n1cnc2c(C(F)(F)F)cccc21>>CCS(=O)(=O)c1cc(F)cc(Oc2ccc(-n3cnc4c(C(F)(F)F)cccc43)c(C)c2)c1",
        "output": "564"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(-c2nc(SC)oc2-c2ccc(OCc3ccccc3)cc2)cn1.CSc1ccccc1.O=C(O)C(F)(F)F>>COc1ccc(-c2nc(SC)oc2-c2ccc(O)cc2)cn1",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)OB(OC(C)C)OC(C)C.CCOCC.FC(F)(F)c1ccc(Br)c(-c2ccncc2)c1.[Li]CCCC>>OB(O)c1ccc(C(F)(F)F)cc1-c1ccncc1",
        "output": "832"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(B(O)O)cn1.CCOC(=O)c1cn(CC)c2ncc(Br)cc2c1=O.O.O=C([O-])[O-].[Cs+].[Cs+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCNC(=O)Nc1cc(-c2nc(C(F)(F)F)cs2)c(-c2cnc3c(c2)c(=O)c(C(=O)OCC)cn3CC)cn1",
        "output": "883"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCc1nc(C)n(-c2ccc(C(C)(C)C)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1nc(C)n(-c2ccc(C(C)(C)C)cc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(C)=O.COC(=O)[C@@H]1C[C@H]1C(=O)c1ccc(Br)cc1.Cc1ccccc1.ClCCl.Cl[Pd]Cl.Nc1ccc(B(O)O)cc1.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COC(=O)[C@@H]1C[C@H]1C(=O)c1ccc(-c2ccc(N)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Cl.CN(C)c1ccncc1.Cc1nc(C(O)(c2nc(C)c(C)s2)C(F)(F)F)sc1C.ClCCl>>CC(=O)OC(c1nc(C)c(C)s1)(c1nc(C)c(C)s1)C(F)(F)F",
        "output": "126"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "N#Cc1ccc(CCC(=O)N2CCCc3cc(S(=O)(=O)Cl)ccc32)cc1.Nc1ccccc1.c1ccncc1>>N#Cc1ccc(CCC(=O)N2CCCc3cc(S(=O)(=O)Nc4ccccc4)ccc32)cc1",
        "output": "68"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC=O.CN(C)C=O.N[C@@H]1CC[C@@H](Nc2nc(N3CCOCC3)cc(-n3c(C(F)F)nc4ccccc43)n2)CC1.O=Cc1ccccc1>>CCN[C@@H]1CC[C@@H](Nc2nc(N3CCOCC3)cc(-n3c(C(F)F)nc4ccccc43)n2)CC1",
        "output": "426"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(Br)cc23)cc1.Cl.Nc1ccc2[nH]ncc2c1>>Brc1ccc2nc(Nc3ccc4[nH]ncc4c3)c3n[nH]cc3c2c1",
        "output": "998"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O.[N-]=[N+]=NCCOCCOCCC12CC3CC(CC(C3)C1)C2.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NCCOCCOCCC12CC3CC(CC(C3)C1)C2",
        "output": "89"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.COc1ccc(-c2ccc3c(c2)c(Cc2ccccc2)c(-c2ccccc2)n3C)cc1.ClCCl>>Cn1c(-c2ccccc2)c(Cc2ccccc2)c2cc(-c3ccc(O)cc3)ccc21",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(CC)CC.O=C(Cl)Oc1ccccc1.OCC1CO1>>O=C(OCC1CO1)Oc1ccccc1",
        "output": "144"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.COc1ccc(CCCO)c(OC)c1.O=C([O-])O.[Na+].c1c[nH]cn1>>COc1ccc(CCCO[Si](C)(C)C(C)(C)C)c(OC)c1",
        "output": "193"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCC(=O)Cl.Cc1[nH]c2c(-c3cc(C(F)F)ccc3OCC3CC3)ncnc2c1C(=O)N[C@H]1CC[C@H](N)C[C@H]1F>>COCC(=O)N[C@H]1CC[C@H](NC(=O)c2c(C)[nH]c3c(-c4cc(C(F)F)ccc4OCC4CC4)ncnc23)[C@H](F)C1",
        "output": "45"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C1(CCCn2c(=O)cnc3ccccc32)CCN(CCSc2cccs2)CC1.O.[Na+].[OH-]>>O=C(O)C1(CCCn2c(=O)cnc3ccccc32)CCN(CCSc2cccs2)CC1",
        "output": "281"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)CN(CCN(CCN(CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C)[C@@H](CCCCN)C(=O)OC(C)(C)C)CC(=O)OC(C)(C)C.CCCCCCCCCCCCCCCCCC(=O)Cl.ClC(Cl)Cl>>CCCCCCCCCCCCCCCCCC(=O)NCCCC[C@@H](C(=O)OC(C)(C)C)N(CCN(CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrC(Br)(Br)Br.OCCCCCCC1=C(c2ccccc2)CCCc2cc(O)ccc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Oc1ccc2c(c1)CCCC(c1ccccc1)=C2CCCCCCBr",
        "output": "378"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)Cc1ccc(N)cc1.O.O=C(O)c1cc([N+](=O)[O-])ccc1Cl.O=S(Cl)Cl>>CCOC(=O)Cc1ccc(NC(=O)c2cc([N+](=O)[O-])ccc2Cl)cc1",
        "output": "50"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN1C(=O)C(CCO)Oc2cc([N+](=O)[O-])ccc21.CI.CN(C)C=O.O.[H-].[Na+]>>CCN1C(=O)C(CCOC)Oc2cc([N+](=O)[O-])ccc21",
        "output": "140"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.CSc1ncc(Br)cc1C(=O)O.O=S(Cl)Cl>>COC(=O)c1cc(Br)cnc1SC",
        "output": "521"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc(S)cc1OC.O=C1CCc2cc(OCCCCCl)ccc2N1.O=S(=O)(OCCCCCl)c1ccccc1.O=c1ccc2cc(O)ccc2[nH]1>>COc1ccc(SCCCCOc2ccc3c(c2)CCC(=O)N3)cc1OC",
        "output": "460"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCCCCCCCCCN2C(=O)c3ccccc3C2=O)C1c1cccc([N+](=O)[O-])c1.NN.O>>COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCCCCCCCCCN)C1c1cccc([N+](=O)[O-])c1",
        "output": "242"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CCOc1cc(-c2ccncc2)ccc1[N+](=O)[O-].CO>>CCOc1cc(-c2ccncc2)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1C[C@@H]2C[C@H]1CN2.CN1CCOCC1.ClCCCl.ClCCl.O.O=C(O)c1ccc(-c2ccccc2)cn1.On1nnc2ccccc21>>CC(C)(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1C[C@@H]2C[C@H]1CN2C(=O)c1ccc(-c2ccccc2)cn1",
        "output": "605"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COC(=O)C(C)Oc1cc(Cl)ncn1.Cn1c(C(F)(F)F)cc(=O)n(-c2cc(O)c(Cl)cc2F)c1=O.O=C([O-])[O-].[K+].[K+]>>COC(=O)C(C)Oc1cc(Oc2cc(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)c(F)cc2Cl)ncn1",
        "output": "668"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)N1CC2CC(C(=O)O)CC2C1.ClCCl.OCC(F)(F)F>>CC(C)(C)OC(=O)N1CC2CC(C(=O)OCC(F)(F)F)CC2C1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCn1c(CCCc2cccc(B3OC(C)(C)C(C)(C)O3)c2)nn(Cc2ccc(C(C)(C)C)cc2)c1=O.COCCOC.COc1ccc(Br)cc1CCC(=O)O.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd].[Pd]>>CCn1c(CCCc2cccc(-c3ccc(OC)c(CCC(=O)O)c3)c2)nn(Cc2ccc(C(C)(C)C)cc2)c1=O",
        "output": "933"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.CCCC[N+](CCCC)(CCCC)CCCC.CS(C)=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Br)cn1.[I-].[K+].[K+]>>O=[N+]([O-])c1ccc(N2CCOCC2)cn1",
        "output": "597"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.CCc1cc(O)c2c(c1)OC(C)(C)c1ccncc1-2.c1ccncc1>>CCc1cc(OC(C)=O)c2c(c1)OC(C)(C)c1ccncc1-2",
        "output": "46"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)/C=C/C(=O)c1nn(-c2ccc(OC(F)(F)F)cc2)ccc1=O.NNc1ccccc1>>O=c1ccn(-c2ccc(OC(F)(F)F)cc2)nc1-c1ccnn1-c1ccccc1",
        "output": "984"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1ccc2c(c1)OCCO2.O=C(O)C1CCC(Nc2nc(Cl)ncc2F)CC1.Oc1cccc(Nc2ncc(F)c(Nc3ccc4c(c3)OCCO4)n2)c1>>O=C(O)C1CCC(Nc2nc(Nc3ccc4c(c3)OCCO4)ncc2F)CC1",
        "output": "907"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H]2[C@@H](C1)c1cc(Br)cc3c1N2CCS3.COc1ccc(B(O)O)c(C)c1>>COc1ccc(-c2cc3c4c(c2)[C@@H]2CN(C(=O)OC(C)(C)C)CC[C@@H]2N4CCS3)c(C)c1",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.COC(=O)c1ccc2c(C3CCCCC3)c(-c3cccc([N+](=O)[O-])c3OCCO)[nH]c2c1.CS(=O)(=O)Cl.ClC(Cl)Cl.O=C([O-])O.[Na+]>>COC(=O)c1ccc2c(C3CCCCC3)c(-c3cccc([N+](=O)[O-])c3OCCOS(C)(=O)=O)[nH]c2c1",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrBr.ClCCl.Fc1cccc(F)c1C(F)(F)F.[Fe]>>Fc1ccc(Br)c(F)c1C(F)(F)F",
        "output": "98"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COc1cccc(O)c1C(=O)O.ClCCl.O=S(Cl)Cl>>COc1cccc(O)c1C(=O)Cl",
        "output": "3"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(c2cccnc2)CO1.CN(C)C=O.Cc1ccc2[nH]c3c(c2c1)CN(C)C(C)C3.[H-].[Na+]>>Cc1ccc2c(c1)c1c(n2CC(C)(O)c2cccnc2)CC(C)N(C)C1",
        "output": "749"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc2cc(C(=O)O)c(C)nc2c1.NC[C@H]1CN(c2ccc(N3CCSCC3)c(F)c2)C(=O)O1>>COc1ccc2cc(C(=O)NC[C@H]3CN(c4ccc(N5CCSCC5)c(F)c4)C(=O)O3)c(C)nc2c1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CC(O)C1.CCN(CC)CC.CS(=O)(=O)Cl.O>>CC(C)(C)OC(=O)N1CC(OS(C)(=O)=O)C1",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CCn1c(=O)[nH]c2c(c1=O)CNCC2.CCN(CC)CC.Cl.ClCCl.O.O=C(Cl)c1ccc(Cl)cc1>>C#CCn1c(=O)[nH]c2c(c1=O)CN(C(=O)c1ccc(Cl)cc1)CC2",
        "output": "201"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCCCCCCCC(O)C(=O)OC.CCCCCCCCCCCCNCC(O)CO.[K+].[OH-]>>CCCCCCCCCCCCCCC(O)C(=O)N(CCCCCCCCCCCC)CC(O)CO",
        "output": "227"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)c1nc(-c2cccc(NS(=O)(=O)C3CC3)c2)c(-c2ccnc(Cl)n2)s1.CS(=O)(=O)CCN>>CC(C)c1nc(-c2cccc(NS(=O)(=O)C3CC3)c2)c(-c2ccnc(NCCS(C)(=O)=O)n2)s1",
        "output": "544"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.O=C(Nc1ccn(-c2cccc(C(F)(F)F)c2)n1)c1cc(Cl)ccc1[N+](=O)[O-].[Zn]>>Nc1ccc(Cl)cc1C(=O)Nc1ccn(-c2cccc(C(F)(F)F)c2)n1",
        "output": "486"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(=O)(=O)OCCc1cc2cc(-c3ccc(C(=O)N4CCOCC4)cc3)ccc2o1.O[C@@H]1CCNC1>>O=C(c1ccc(-c2ccc3oc(CCN4CC[C@@H](O)C4)cc3c2)cc1)N1CCOCC1",
        "output": "496"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1cccc(I)c1.CC(C)(C)C(=O)CC(=O)C(C)(C)C.CN1CCCC1=O.Cl[Cu].O=C([O-])[O-].Oc1ccc(Cl)cc1Oc1ccccc1.[Cs+].[Cs+]>>Clc1ccc(Oc2cccc(Br)c2)c(Oc2ccccc2)c1",
        "output": "382"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Br.Br.C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1nc2c(s1)CC(C)NCC2.Cc1nc2c(s1)CNC(C)CC2.O.[Na+].[OH-]>>Cc1nc2c(s1)CC(C)N(C(=O)OC(C)(C)C)CC2",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC#N.CO.COCCO.O.O=C(O)C(F)(F)F.O=C(O)c1ccc(NS(=O)(=O)c2cc(Cl)sc2Cl)cc1O.O=C(n1ccnc1)n1ccnc1.c1ccncc1>>COCCOC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)sc2Cl)cc1O",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2cc(Cl)ccc2F)c(C2=CCCC2(C)C)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC1(C)CCC=C1c1cc(CO)ccc1-c1cc(Cl)ccc1F",
        "output": "444"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CC(NC(=O)OCC2c3ccccc3-c3ccccc32)(C(=O)O)C1.CCN=C=NCCCN(C)C.Cc1sc(N)c(C(=O)c2ccc(Cl)cc2)c1C.Cl.ClCCl>>Cc1sc(NC(=O)C2(NC(=O)OCC3c4ccccc4-c4ccccc43)CN(C(=O)OC(C)(C)C)C2)c(C(=O)c2ccc(Cl)cc2)c1C",
        "output": "882"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.CN(C)C=O.CN(C)CCN.CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(C(=O)O)c1)CC2.ClCCl.O.O=C(Cl)C(=O)Cl.[Na+].[OH-]>>CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(C(=O)NCCN(C)C)c1)CC2",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCCl.CCc1c(N(C(C)=O)c2cc(C)cc(C)c2)[nH]c(=O)[nH]c1=O.C[Si](C)(C)Cl.C[Si](C)(C)N[Si](C)(C)C.Cl[Sn](Cl)(Cl)Cl.O=C([O-])O.[Na+]>>CCOCn1c(N(C(C)=O)c2cc(C)cc(C)c2)c(CC)c(=O)[nH]c1=O",
        "output": "712"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C(=O)O)n1cc(-c2ccc3c(c2)OCCc2sc(-c4ncnn4CC(F)(F)F)nc2-3)cn1.[Cl-].[NH4+]>>CC(C)(C(N)=O)n1cc(-c2ccc3c(c2)OCCc2sc(-c4ncnn4CC(F)(F)F)nc2-3)cn1",
        "output": "313"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.OCCN1CCNCC1>>CC(C)(C)OC(=O)N1CCN(CCO)CC1",
        "output": "694"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CCN1CCNCC1.CCN(C(C)C)C(C)C.Cl.ClC(Cl)Cl.Oc1ccc(CCl)c2cccnc12>>C#CCN1CCN(Cc2ccc(O)c3ncccc23)CC1",
        "output": "156"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(N)c1cccc(Br)n1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.O=C1CCN2CCC1CC2>>CN(/N=C1/CCN2CCC1CC2)c1cccc(Br)n1",
        "output": "285"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(C#Cc2cn(COCC[Si](C)(C)C)c3ncnc(N)c23)cc(OC)c1.ClCCl.O=C(O)C(F)(F)F>>COc1cc(C#Cc2c[nH]c3ncnc(N)c23)cc(OC)c1",
        "output": "897"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1c[nH]cc1C#N.CO.Cl.[Na+].[OH-]>>N#Cc1c[nH]cc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNC1.Fc1ccc(-c2csc3cc(OCCCBr)ccc23)cc1>>Fc1ccc(-c2csc3cc(OCCCN4CCC4)ccc23)cc1",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N1CC2CNCC2C1.Cc1cc(C)nc(N2CC3CNCC3C2)n1.Cc1noc(-c2ccccc2C(=O)O)n1.O=C(O)c1ccccc1-c1nnc[nH]1>>Cc1cc(C)nc(N2CC3CN(C(=O)c4ccccc4-c4nc(C)no4)CC3C2)n1",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CCOC(=O)c1cn(-c2ccc(F)c(OC)c2)c2c(C)c(F)c(F)cc2c1=O.Cl>>COc1cc(-n2cc(C(=O)O)c(=O)c3cc(F)c(F)c(C)c32)ccc1F",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCO.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1ccc(-c2ccc(CN)cn2)cc1.ClCCl.Cn1cc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1C(=O)O.F[B-](F)(F)F>>Cc1ccc(-c2ccc(CNC(=O)c3cc(NC(=O)c4ccccc4-c4ccc(C(F)(F)F)cc4)cn3C)cn2)cc1",
        "output": "137"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(N=[N+]=[N-])c1ccc2ncccc2c1.CCO.[H][H].[Pd]>>CC(C)(N)c1ccc2ncccc2c1",
        "output": "562"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CCC[C@@H](C)O[C@@H](CC)[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)O.C=C[C@@H]1C[C@]1(N)C(=O)NS(=O)(=O)C1(CF)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)C(F)(F)F>>C=CCC[C@@H](C)O[C@@H](CC)[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@]1(C(=O)NS(=O)(=O)C2(CF)CC2)C[C@H]1C=C",
        "output": "131"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COC(=O)c1ccc(Cn2c(=O)[nH]c3ccccc32)cc1.Cl.[Li+].[OH-]>>O=C(O)c1ccc(Cn2c(=O)[nH]c3ccccc32)cc1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC1(CS(=O)(=O)Cl)NC(=O)NC1=O.C[C@]1(CS(=O)(=O)Cl)NC(=O)NC1=O.Cc1cc(COC2CCNCC2)c2ccccc2n1.Cc1cc(COCC2CCNCC2)c2ccccc2n1>>Cc1cc(COCC2CCN(S(=O)(=O)C[C@@]3(C)NC(=O)NC3=O)CC2)c2ccccc2n1",
        "output": "584"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1=CCCCC1.CCO.Cc1ccc(N2CCN(C)CC2)cc1[N+](=O)[O-].[Pd]>>Cc1ccc(N2CCN(C)CC2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1=COCCC1.CCOC(=O)c1cnn(C)c1CO.Cc1ccc(S(=O)(=O)O)cc1.ClC(Cl)Cl.O=C([O-])O.[Na+]>>CCOC(=O)c1cnn(C)c1COC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(c1cccc(OCC(N)=O)c1)c1cc(Br)cc([N+](=O)[O-])c1.COC(=O)c1cc2cc(OC)ccc2s1>>COC(=O)c1cc2cc(O)ccc2s1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O=C(O)Cc1cccc2ccc(O)cc12.O=S(Cl)Cl>>COC(=O)Cc1cccc2ccc(O)cc12",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCOC[C@H](N)C(=O)OC.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cc2ccccc2cc1C(=O)O>>CCCCOC[C@H](NC(=O)c1cc2ccccc2cc1N)C(=O)OC",
        "output": "652"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(C)=O.Fc1cc(C(F)(F)F)ccn1.O.O=C([O-])[O-].O=S1(=O)CCN2C(=N1)C1(c3ccc(O)cc3)CCC2CC1.[K+].[K+]>>O=S1(=O)CCN2C(=N1)C1(c3ccc(Oc4cc(C(F)(F)F)ccn4)cc3)CCC2CC1",
        "output": "727"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)C=O.C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cc2cccc(Cl)c2c(C(=O)O)n1.Cl.ClCCl.NC1CCOCC1.O.O=C(Cl)C(=O)Cl>>C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cc2cccc(Cl)c2c(C(=O)NC2CCOCC2)n1",
        "output": "137"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1cccc([N+](=O)[O-])c1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C.[Ni]>>COC(=O)c1cccc(N)c1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C",
        "output": "481"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C(=O)c1ccc2c(S(C)=O)cn(-c3ncc(Br)cn3)c2c1.COc1ccc(F)c(B(O)O)c1>>COc1ccc(F)c(-c2cnc(-n3cc(S(C)=O)c4ccc(C(=O)N(C)C)cc43)nc2)c1",
        "output": "871"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)C(=O)CC(=O)c1cccc(C2CCCc3ccccc32)c1.CO.O.[Na+].[OH-]>>O=C(O)C(=O)CC(=O)c1cccc(C2CCCc3ccccc32)c1",
        "output": "472"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C#N)c1cc(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)cs1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>CC(C)(C#N)c1cc(CO)cs1",
        "output": "781"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CCN(CC)CC.ClCCl.N#Cc1ccc(CBr)cc1>>N#Cc1ccc(CN2CCOCC2)cc1",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)Cc1ccc(OC(C)C)cc1.O.[Na+].[OH-]>>CC(C)Oc1ccc(CC(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=COCCN.CC(=O)Cc1ccccc1.O.[BH4-].[Na+].c1ccccc1>>C=COCCNC(C)Cc1ccccc1",
        "output": "236"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1ccc(-c2cnc3nc(NCc4ccc(S(N)(=O)=O)cc4)nc(NCC(F)(F)F)c3n2)cc1.CO.Cl.[Na+].[OH-]>>NS(=O)(=O)c1ccc(CNc2nc(NCC(F)(F)F)c3nc(-c4ccc(C(=O)O)cc4)cnc3n2)cc1",
        "output": "5"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(CC)CC.Cc1ccccc1N1CCNCC1.O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1>>Cc1ccccc1N1CCN(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)CC1",
        "output": "99"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COCCO.O=C(O)Cn1nnnc1-c1ccsc1.O=S(=O)(O)O>>COCCOC(=O)Cn1nnnc1-c1ccsc1",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.COC(=O)c1cc(N2CCCCC2)nc(Cl)n1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.OB(O)c1ccc(-c2ccccc2)cc1.[F-].[K+].[Pd].[Pd]>>COC(=O)c1cc(N2CCCCC2)nc(-c2ccc(-c3ccccc3)cc2)n1",
        "output": "874"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Nc1cccc(C(=O)O)c1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>Nc1cccc(CO)c1",
        "output": "72"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCNCC.Cc1cc(-c2noc(-c3cc(C)nc(Cl)c3)n2)ccn1.O=C([O-])[O-].[Cs+].[Cs+]>>CCN(CC)c1cc(-c2nc(-c3ccnc(C)c3)no2)cc(C)n1",
        "output": "220"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1ccc(NC(=O)C(F)(F)F)c(Br)c1.CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCO.[Br-].[Br-].[Br-]>>O=C(CBr)c1ccc(NC(=O)C(F)(F)F)c(Br)c1",
        "output": "360"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=Cc1cc(OC(F)(F)F)ccc1O.O=c1cc(N2CCNCC2)nc[nH]1>>O=c1cc(N2CCN(Cc3cc(OC(F)(F)F)ccc3O)CC2)nc[nH]1",
        "output": "567"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCS(N)(=O)=O.O=C(O)c1cnn2c(Nc3ccccc3Cl)c(C(=O)N3CCC(c4ccccc4)CC3)cnc12>>CCS(=O)(=O)NC(=O)c1cnn2c(Nc3ccccc3Cl)c(C(=O)N3CCC(c4ccccc4)CC3)cnc12",
        "output": "991"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCC1(C(=O)Nc2cccc(Cl)c2)CCNCC1.CC(C)O.CCN(C(C)C)C(C)C.Cc1c[nH]c2ncnc(Cl)c12.ClCCl>>C=CCC1(C(=O)Nc2cccc(Cl)c2)CCN(c2ncnc3[nH]cc(C)c23)CC1",
        "output": "540"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)OC)cc2OCC2CC2)c1.CO.[Na+].[OH-]>>CCCCCCCNC(=O)N(C)c1cccc(-c2ccc(CCC(=O)O)cc2OCC2CC2)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCN(CCCN1C(=O)c2ccccc2C1=O)C1CCc2c(cccc2OC)C1.Cl.[NH4+].[OH-].c1ccncc1>>CCCN(CCCN1C(=O)c2ccccc2C1=O)C1CCc2c(O)cccc2C1",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1cccc(-c2cccc(-c3cccc(-c4cccc(OC)c4O)n3)n2)c1O.ClCCl>>Oc1cccc(-c2cccc(-c3cccc(-c4cccc(O)c4O)n3)n2)c1O",
        "output": "20"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCCCc1ccccc1.CN(C)C=O.C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H](C)N1.O.O=C([O-])[O-].[K+].[K+]>>C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H](C)N1CCCc1ccccc1",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.COc1cc([N+](=O)[O-])ccc1C=O.Cl.O.[Na+].[OH-]>>COc1cc([N+](=O)[O-])ccc1C=CC(C)=O",
        "output": "295"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CC(O)c1ccc(Br)c(F)c1.Oc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(Oc1ccccc1)c1ccc(Br)c(F)c1",
        "output": "342"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCC.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CO.CS(=O)(=O)c1ccc(Oc2cc(OC3CCOCC3)c3[nH]c(C4=NCC(CC(=O)O)S4)cc3c2)cn1.Cl.Cl.N#CCN.O.O.On1nnc2ccccc21>>CS(=O)(=O)c1ccc(Oc2cc(OC3CCOCC3)c3[nH]c(C4=NCC(CC(=O)NCC#N)S4)cc3c2)cn1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COCCOC.Cn1ncc(Br)c1Nc1ccc(I)cc1.Nc1cccc(B(O)O)c1.O.O=C([O-])[O-].[Cs+].[Cs+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cn1ncc(Br)c1Nc1ccc(-c2cccc(N)c2)cc1",
        "output": "855"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccccc1Oc1c(Cl)nc(C)nc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1.OCCCO.[Na]>>COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCCO",
        "output": "653"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccn2c(-c3cccc(OS(=O)(=O)C(F)(F)F)c3)cnc2n1.OB(O)c1ccccc1F>>Cc1ccn2c(-c3cccc(-c4ccccc4F)c3)cnc2n1",
        "output": "825"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CCBr.CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2CC.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>C#CCOc1cc2c(cc1OC)-c1cc(=O)c(C(=O)OCC)cn1C(CC)C2",
        "output": "154"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)C1.CCN(CC)CC.CS(C)=O.Cl>>CC(C)(C)OC(=O)N1CCC(=O)C1",
        "output": "650"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cl.N#Cc1cc(OCC(F)(F)F)c(C(F)(F)F)cc1[N+](=O)[O-].[Fe]>>N#Cc1cc(OCC(F)(F)F)c(C(F)(F)F)cc1N",
        "output": "202"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1ccc(OC)c(-c2nc3ccccc3n2CC(=O)O)c1.F[P-](F)(F)(F)(F)F.Nc1cc(Oc2ccc(-c3ccccc3)cc2)ccc1F>>COc1ccc(OC)c(-c2nc3ccccc3n2CC(=O)Nc2cc(Oc3ccc(-c4ccccc4)cc3)ccc2F)c1",
        "output": "365"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COc1cc(C(=O)Nc2nc3c(OC)ccc(C4CCN(C(=O)OC(C)(C)C)CC4)c3s2)ccn1.Cl>>COc1cc(C(=O)Nc2nc3c(OC)ccc(C4CCNCC4)c3s2)ccn1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#Cc1cccnc1N.C1CCOC1.CCN(CC)CC.Cc1ccc(OCc2ccc(CC(Cl)=NO)cc2)nc1.O>>Cc1ccc(OCc2ccc(Cc3cc(-c4cccnc4N)on3)cc2)nc1",
        "output": "976"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CCN(CC)CCNC(=O)c1cc(C)c(C=O)[nH]1.CCO.O=C1Cc2c(cccc2-c2cccc(Br)c2)N1>>CCN(CC)CCNC(=O)c1cc(C)c(C=C2C(=O)Nc3cccc(-c4cccc(Br)c4)c32)[nH]1",
        "output": "440"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CSc1cccc(N=C=O)c1.ClCCl.NC1CCN(CC23CC4CC(CC(C4)C2)C3)CC1>>CSc1cccc(NC(=O)NC2CCN(CC34CC5CC(CC(C5)C3)C4)CC2)c1",
        "output": "35"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "B.C1CCOC1.C1CCOC1.COc1cc(C(=O)O)ccc1Cl>>COc1cc(CO)ccc1Cl",
        "output": "72"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccc(N)cc1.CO.O=C(Nc1cccc(C(=O)O)c1)Nc1nnc(-c2cc(Cl)cc(Cl)c2O)s1.On1nnc2ccccc21.On1nnc2ccccc21>>CN(C)c1ccc(NC(=O)c2cccc(NC(=O)Nc3nnc(-c4cc(Cl)cc(Cl)c4O)s3)c2)cc1",
        "output": "50"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCC[C@@H](O)C2)c(Br)c1.OB(O)c1cccnc1>>O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCC[C@@H](O)C2)c(-c2cccnc2)c1",
        "output": "883"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cc1ccc([N+](=O)[O-])cc1C(=O)Nc1cnc2[nH]cnc2c1.[Pd]>>Cc1ccc(N)cc1C(=O)Nc1cnc2[nH]cnc2c1",
        "output": "489"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Cc1cc(C)c(CNC(=O)c2cc(Cl)nc3c2cnn3C(C)C)c(=O)[nH]1.NC1CCOCC1>>Cc1cc(C)c(CNC(=O)c2cc(NC3CCOCC3)nc3c2cnn3C(C)C)c(=O)[nH]1",
        "output": "70"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC(Oc2cc(Br)ccc2C=O)C1.CC(C)(C)P([c-]1cccc1)C(C)(C)C.CCOC(C)=O.Cc1ccccc1.O=P([O-])([O-])[O-].OB(O)c1ccccc1C(F)(F)F.[Fe+2].[K+].[K+].[K+].c1ccc(-c2c(-c3ccccc3)c(-c3ccccc3)[c-](-c3ccccc3)c2-c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CC(Oc2cc(-c3ccccc3C(F)(F)F)ccc2C=O)C1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)[O-].O.O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H]1O[C@H](O[C@]2(CO)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O.[Na+]>>N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O",
        "output": "151"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cccc(-c2cn3nc(N)nc3cn2)c1.CN1CCCC1=O.Cc1ccccc1.N#Cc1ccccc1Br.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CCOC(=O)c1cccc(-c2cn3nc(Nc4ccccc4C#N)nc3cn2)c1",
        "output": "970"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=N.CCOCC.CN(C)C=O.CN(C)c1cccc(Oc2ncccc2C(=O)O)c1.Cl.Cl.NCc1ccccc1Cl.O.O.On1nnc2ccccc21.[Cl-]>>CN(C)c1cccc(Oc2ncccc2C(=O)NCc2ccccc2Cl)c1",
        "output": "790"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCCO[Si](C)(C)C(C)(C)C)cc3)cc12.O.[F-]>>Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCCO)cc3)cc12",
        "output": "708"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CN1CCOCC1.COc1nc(Cl)nc(OC)n1.Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1cc(C(=O)O)ccc1F.O.[NH4+].[OH-]>>Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1cc(C(N)=O)ccc1F",
        "output": "358"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)CCNCC1.O=CCCNC(=O)c1cc([N+](=O)[O-])c(Sc2c(Cl)cncc2Cl)s1>>CC1(C)CCN(CCCNC(=O)c2cc([N+](=O)[O-])c(Sc3c(Cl)cncc3Cl)s2)CC1",
        "output": "484"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1ccc(O)cc1O.CC(C)=O.C[Si](C)(C)CCOCCl.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1ccc(OCOCC[Si](C)(C)C)cc1O",
        "output": "375"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNC1.C1CCOC1.Cc1ncc(-c2ccnc(NC3CCN(S(=O)(=O)CCCCl)CC3)n2)n1C(C)C.[I-].[Na+]>>Cc1ncc(-c2ccnc(NC3CCN(S(=O)(=O)CCCN4CCCC4)CC3)n2)n1C(C)C",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)Oc1ccc(CBr)cc1.CN(C)C=O.Nc1nccn2c(C3CCC3)nc(-c3cccc(O)c3)c12.O=C([O-])[O-].[Cs+].[Cs+]>>CC(C)(C)Oc1ccc(COc2cccc(-c3nc(C4CCC4)n4ccnc(N)c34)c2)cc1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)C(c1ccc(CN2Cc3ccccc3C2=O)cc1)C(C)C(F)(F)F.CO.Cl.O.[Li+].[OH-]>>CC(C(C(=O)O)c1ccc(CN2Cc3ccccc3C2=O)cc1)C(F)(F)F",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN.O=Cc1cccnc1>>CCNCc1cccnc1",
        "output": "441"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ncc(CN(C(=O)OC(C)(C)C)c2ccc(C#N)cc2)c(CO)c1O.N#Cc1cccc(CBr)c1>>Cc1ncc(CN(C(=O)OC(C)(C)C)c2ccc(C#N)cc2)c(CO)c1OCc1cccc(C#N)c1",
        "output": "623"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)NCC(=O)O)ccc21.F[P-](F)(F)(F)(F)F.OCC1CCNCC1>>Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)NCC(=O)N3CCC(CO)CC3)ccc21",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1nn(-c2ccc(Cl)cc2Cl)c(-c2ccc(OCCCF)cc2)c1C.O.[K+].[OH-]>>Cc1c(C(=O)O)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(OCCCF)cc1",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F.Fc1ccc(C2CCNC2)cc1.O=C(O)C(=O)O.O=C(O)c1cnoc1-c1ccc(C(F)(F)F)cc1.c1ccncc1>>O=C(c1cnoc1-c1ccc(C(F)(F)F)cc1)N1CCC(c2ccc(F)cc2)C1",
        "output": "975"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)Cc1cccc(Nc2cccc([N+](=O)[O-])c2)c1[N+](=O)[O-].[Pd]>>CCOC(=O)Cc1cccc(Nc2cccc(N)c2)c1N",
        "output": "204"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O.CC(C)(C)[Si](C)(C)OCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc21.O>>O=C(NCC(F)(F)F)C1(CCO)c2ccccc2-c2ccccc21",
        "output": "708"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(N[C@H](Cc2ccc(Cl)cc2)C(=O)N2C3CCC2CC(Cn2cncn2)(C2CCCCC2)C3)CC1.Cl>>O=C([C@@H](Cc1ccc(Cl)cc1)NC1CCNCC1)N1C2CCC1CC(Cn1cncn1)(C1CCCCC1)C2",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(C)=O.CSc1nc(C#N)cn2ccnc12.O.O=C([O-])O.O=C1CCC(=O)N1Br.[Na+]>>CSc1nc(C#N)cn2c(Br)cnc12",
        "output": "665"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.COC(=O)CCCc1nc(-c2ccccc2N)co1.[Na+].[OH-]>>Nc1ccccc1-c1coc(CCCC(=O)O)n1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCc1cc(OC2CCNCC2)c2ncccc2c1.CCOC(=O)CCCBr.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCCCCc1cc(OC2CCN(CCCC(=O)OCC)CC2)c2ncccc2c1",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)[C@@H]1CC[C@@H](C=C(Br)Br)CC1.[K+].[OH-]>>O=C(O)[C@@H]1CC[C@@H](C=C(Br)Br)CC1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(-c3ccccn3)cc2)CC1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=S([O-])([O-])=S.[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(-c3cccc[n+]3[O-])cc2)CC1",
        "output": "262"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.C[C@@H](C(N)=O)n1ccc2c([N+](=O)[O-])c(Cl)ccc2c1=O.ClCCl.O.[Cl-].[Fe].[NH4+]>>C[C@@H](C(N)=O)n1ccc2c(N)c(Cl)ccc2c1=O",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1nn(Cc2cccc(F)c2)c(C)c1-c1c[nH]c2ncc(-c3ccc(C4CCN(C(=O)OC(C)(C)C)CC4)cc3)cc12.ClCCl.O=C(O)C(F)(F)F>>Cc1nn(Cc2cccc(F)c2)c(C)c1-c1c[nH]c2ncc(-c3ccc(C4CCNCC4)cc3)cc12",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N.F[P-](F)(F)(F)(F)F.Nc1c(C(=O)O)sc2nccnc12.O=C(O)CC(O)(CC(=O)O)C(=O)O>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1NC(=O)c1sc2nccnc2c1N",
        "output": "822"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.c1cc(C2CCCN2)ccn1>>Cc1ccc(S(=O)(=O)N2CCCC2c2ccncc2)cc1",
        "output": "99"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Fc1ccc(N2CCNCC2)cc1F.O=C1CC2(CCCC2)CC(=O)N1CCCl>>O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(F)c(F)c2)CC1",
        "output": "138"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.CNCCN(C)C.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[K+].[K+]>>CN(C)CCN(C)c1ccc([N+](=O)[O-])cc1",
        "output": "26"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O=C(Nc1cccc2c1C(=O)N(Cc1ccc(NCCO)cc1)C2)c1ccc(Cl)s1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCNc1ccc(CN2Cc3cccc(NC(=O)c4ccc(Cl)s4)c3C2=O)cc1",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.O=C(O)c1ccc(OCC(F)(F)C(F)(F)F)cc1O.c1ccncc1>>CC(=O)Oc1cc(OCC(F)(F)C(F)(F)F)ccc1C(=O)O",
        "output": "46"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)C1CCCNC1.O>>CCOC(=O)C1CCCN(C(=O)OC(C)(C)C)C1",
        "output": "694"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)/C=C/c1cc(C2CC2)nn1Cc1ccc(C(F)(F)F)cc1Cl.[Na+].[OH-]>>O=C(O)/C=C/c1cc(C2CC2)nn1Cc1ccc(C(F)(F)F)cc1Cl",
        "output": "122"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.NC(N)=O.Nc1cc2c(cc1[N+](=O)[O-])CCC2.O.O=C([O-])O.O=N[O-].O=S(=O)(O)O.[I-].[K+].[Na+].[Na+]>>O=[N+]([O-])c1cc2c(cc1I)CCC2",
        "output": "200"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O.O=C(O)CCCc1cccc2ccccc12>>O=C1CCCc2c1ccc1ccccc21",
        "output": "274"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)c1ccc2nc(-c3cc4cc(F)ccc4s3)c(N(C)C(C)C)nc2c1.O.[Na+].[OH-]>>CC(C)N(C)c1nc2cc(C(=O)O)ccc2nc1-c1cc2cc(F)ccc2s1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CCn1c(=O)c2cc(NC(=O)CC(C)CN)ccc2n(CC)c1=O.CN(C)C=O.N#Cc1ccc(C(=O)O)cc1.On1nnc2ccccc21>>CCn1c(=O)c2cc(NC(=O)CC(C)CNC(=O)c3ccc(C#N)cc3)ccc2n(CC)c1=O",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cn1c(CC(=O)[O-])nc(N2CCOCC2)cc1=O.Nc1ccc(F)c(C(F)F)c1.[Na+].c1ccncc1>>Cn1c(CC(=O)Nc2ccc(F)c(C(F)F)c2)nc(N2CCOCC2)cc1=O",
        "output": "891"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc(I)cc1.C#Cc1ccccc1.C1CCOC1.CCN(CC)CC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.N#N.[Cu]I>>Brc1ccc(C#Cc2ccccc2)cc1",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(CC)CC.CO.Cl.N#Cc1cccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)c1.NO>>N=C(NO)c1cccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)c1",
        "output": "854"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOc1ccccc1O.OCC1CO1.c1ccncc1>>CCOc1ccccc1OCC(O)CO",
        "output": "277"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)O.Cc1ccc([N+](=O)[O-])c(NC(=O)c2ccccc2)c1.[Cl-].[Fe].[NH4+]>>Cc1ccc(N)c(NC(=O)c2ccccc2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCN(C(=O)CN)c1c(OC)cc(C)cc1OC.COC(=O)Cn1c(C(=O)O)cc2ccccc21>>CCCCN(C(=O)CNC(=O)c1cc2ccccc2n1CC(=O)OC)c1c(OC)cc(C)cc1OC",
        "output": "738"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCC(C)=O.CCOC(=O)C(=O)OCC>>CCCC(=O)CC(=O)C(=O)OCC",
        "output": "526"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1=CCCCC1.CCCOc1ncnc(COCc2ccccc2)c1-c1ccc(OC)cc1OCOC.CCO.O=C[O-].[NH4+].[OH-].[OH-].[Pd+2]>>CCCOc1ncnc(CO)c1-c1ccc(OC)cc1OCOC",
        "output": "178"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)Cc1cccc(Oc2ccc(Br)cc2CSc2ccccc2)c1.CS(=O)(=O)c1ccc(B(O)O)cc1>>CCOC(=O)Cc1cccc(Oc2ccc(-c3ccc(S(C)(=O)=O)cc3)cc2CSc2ccccc2)c1",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc(-c2nc(-c3ccc(S(=O)(=O)C(F)(F)F)cc3)no2)nn1Cc1ccc(Cl)[n+]([O-])c1.NCCN1CCCC1>>Cc1cc(-c2nc(-c3ccc(S(=O)(=O)C(F)(F)F)cc3)no2)nn1Cc1ccc(NCCN2CCCC2)[n+]([O-])c1",
        "output": "70"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1ccc(C2CC(C(=O)O)CN(C(=O)C3CCCC3)C2)cc1.N=C(Cc1ccc(F)cc1)NO>>CCc1ccc(C2CC(c3nc(Cc4ccc(F)cc4)no3)CN(C(=O)C3CCCC3)C2)cc1",
        "output": "924"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.COc1cccnc1N.O=C1CCC(=O)N1Cl>>COc1cc(Cl)cnc1N",
        "output": "743"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)c1cncc(OCc2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)c1.O.[BH4-].[Na+]>>Cc1oc(-c2ccccc2)nc1COc1ccc(COc2cncc(CO)c2)cc1",
        "output": "522"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1c(C(=O)NC2CCOCC2)cc(-c2ccc(C=O)c(C(F)(F)F)c2)n1CC1CCCCC1.ClCCl.[Na+]>>Cc1c(C(=O)NC2CCOCC2)cc(-c2ccc(CN3CCOCC3)c(C(F)(F)F)c2)n1CC1CCCCC1",
        "output": "567"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.CN(C)C=O.Nc1ccc(I)cc1Cl.O=C1OC(=O)c2ccccc21>>O=C1c2ccccc2C(=O)N1c1ccc(I)cc1Cl",
        "output": "475"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCS(=O)(=O)Cl.CN(C)C=O.CN(C)c1ccncc1.NC(=O)c1cc(-c2ccccc2)nc2c(C3CCNCC3)n[nH]c12>>CCS(=O)(=O)N1CCC(c2n[nH]c3c(C(N)=O)cc(-c4ccccc4)nc23)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCNCCCO.ClCCl>>CCN(CCCO)C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NC(Cc1ccccc1)=NO.O=C(O)C1CC(c2ccc(OC(F)(F)F)cc2)CN(C(=O)N2CCOCC2)C1>>O=C(N1CCOCC1)N1CC(c2ccc(OC(F)(F)F)cc2)CC(c2nc(Cc3ccccc3)no2)C1",
        "output": "728"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.ClCC=C(Cl)Cl.O=C([O-])[O-].Oc1cc(Cl)c(OCCCOc2ccc(C(F)(F)F)cn2)c(Cl)c1.[K+].[K+]>>FC(F)(F)c1ccc(OCCCOc2c(Cl)cc(OCC=C(Cl)Cl)cc2Cl)nc1",
        "output": "119"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.Cl.N#Cc1cc(N2CCCCC2)ccc1[N+](=O)[O-].O=C(O)C(F)(F)F.[BH4-].[Na+]>>NCc1cc(N2CCCCC2)ccc1[N+](=O)[O-]",
        "output": "175"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC(O)(CC)COc1ccc(C(CC)(CC)c2cc3ccc(C(=O)OC)cc3s2)cc1C.CO.Cl.O.[Na+].[OH-]>>CCC(O)(CC)COc1ccc(C(CC)(CC)c2cc3ccc(C(=O)O)cc3s2)cc1C",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.O=C1CCCc2cc([N+](=O)[O-])ccc2N1.O=C[O-].[NH4+].[Pd]>>Nc1ccc2c(c1)CCCC(=O)N2",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1cc2cc([N+](=O)[O-])ccc2n1C.O.O=C[O-].[NH4+].[Pd]>>CCOC(=O)c1cc2cc(N)ccc2n1C",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cc1nc2[nH]c(C)c(C)c2c(-c2ccc(Cl)cc2)c1C(O)C(=O)O.O=S(=O)(O)O.[Na+].[OH-]>>COC(=O)C(O)c1c(C)nc2[nH]c(C)c(C)c2c1-c1ccc(Cl)cc1",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCCCCCCBr.O.OCCCc1ccccn1.[Na+].[OH-]>>BrCCCCCCOCCCc1ccccn1",
        "output": "95"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.CO.COC(C)(C)CCOCC(=O)O.Cc1ccc(S(=O)(=O)O)cc1>>COC(=O)COCCC(C)(C)OC",
        "output": "195"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)Cc1ccc(OC)c(Oc2ccc(Br)cc2CN2C(=O)O[C@H](c3ccccc3)[C@@H]2C)c1.COc1ccccc1B(O)O>>COc1ccc(CC(=O)O)cc1Oc1ccc(Br)cc1CN1C(=O)O[C@H](c2ccccc2)[C@@H]1C",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O=[N+]([O-])c1cc(F)c(N2CCNCC2)c(F)c1>>CC(C)(C)OC(=O)N1CCN(c2c(F)cc([N+](=O)[O-])cc2F)CC1",
        "output": "694"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)CCC1(O)CN(C(=O)OC(C)(C)C)C1.ClCCl.[H-]>>CC(C)(C)OC(=O)N1CC(O)(CCCO)C1",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCCOC.Cc1nn(C)c(C)c1B1OC(C)(C)C(C)(C)O1.O.O=C([O-])[O-].O=C1CCc2ccc(Br)cc21.[K+].[K+]>>Cc1nn(C)c(C)c1-c1ccc2c(c1)C(=O)CC2",
        "output": "971"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC.Cc1cc(OCc2ccccc2)c2cc(C(N)=O)[nH]c2c1.OCCO.[H][H].[Pd]>>Cc1cc(O)c2cc(C(N)=O)[nH]c2c1",
        "output": "23"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC1CCN(CCNC(=O)OCc2ccccc2)CC1.CCO.[Pd]>>CC(C)(C)OC(=O)NC1CCN(CCN)CC1",
        "output": "574"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CN(C2CC2)CCN1.CC#N.CCN(C(C)C)C(C)C.CCc1nccc(-c2ccc(C(=O)O)c(F)c2)c1C#Cc1ccc(N)nc1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O>>CCc1nccc(-c2ccc(C(=O)N3CCN(C4CC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)c1ccc(N)cc1.CNc1cc(Cl)ncn1>>CCN(CC)c1ccc(Nc2cc(NC)ncn2)cc1",
        "output": "161"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)OC[C@H](c1cccc(Cl)c1)N(C(=O)N1CCOCC1)C2.NO.[Na+].[OH-]>>O=C(NO)c1ccc2c(c1)OC[C@H](c1cccc(Cl)c1)N(C(=O)N1CCOCC1)C2",
        "output": "988"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCN(CC)CC.CN1CCNCC1.Nc1cc(F)ccc1[N+](=O)[O-]>>CN1CCN(c2ccc([N+](=O)[O-])c(N)c2)CC1",
        "output": "26"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCCBr.CCOC(C)=O.O.Oc1c(Br)cccc1Br.[Na+].[OH-]>>BrCCOc1c(Br)cccc1Br",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cc1c([N+](=O)[O-])cc(C#N)c2nc[nH]c12.[Pd]>>Cc1c(N)cc(C#N)c2nc[nH]c12",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(C2=NC(c3ccc(Cl)cc3)C(c3ccc(Cl)cc3)N2C(=O)N2CCN(C(=O)CNC(=O)OC(C)(C)C)CC2)c(OC(C)C)c1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(C2=NC(c3ccc(Cl)cc3)C(c3ccc(Cl)cc3)N2C(=O)N2CCN(C(=O)CN)CC2)c(OC(C)C)c1",
        "output": "431"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)Nc1ccc(C(CCNCc2ccccc2)c2ccc(NC(=O)OC)cc2)cc1.Cl.[Na+].[OH-]>>COC(=O)Nc1ccc(C(CCN(Cc2ccccc2)C(=O)OC(C)(C)C)c2ccc(NC(=O)OC)cc2)cc1",
        "output": "867"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCO.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cc1cc(C(=O)O)ccc1C(=O)N1CCCC1.ClCCl.ClCl.F[B-](F)(F)F.NC(CN1CCCCC1)c1nc2cc(Cl)ccc2[nH]1>>Cc1cc(C(=O)NC(CN2CCCCC2)c2nc3cc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1",
        "output": "902"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)c1ccc(C(=O)Cl)cc1.COC(=O)C1(N2Cc3ccc(-c4ccc(N)cc4)cc3C2=O)CCCC1.COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccccc4)cc3)cc2C1=O>>COC(=O)C1(N2Cc3ccc(-c4ccc(NC(=O)c5ccc(C(C)(C)C)cc5)cc4)cc3C2=O)CCCC1",
        "output": "11"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.COC(=O)CC(=O)c1ccc(OC)cc1.ClCCl>>COC(=O)CC(=O)c1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC1CCNCC1.Cc1noc(C)c1C(=O)O.Cl.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC1CCN(C(=O)c2c(C)noc2C)CC1",
        "output": "975"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CC[C@H](C)[C@@H]([C@@H](CC(=O)OC(C)(C)C)OC)N(C)C(=O)[C@@H](N)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(NC1(C(=O)O)CCCC1)OCC1c2ccccc2-c2ccccc21>>CC[C@H](C)[C@@H]([C@@H](CC(=O)OC(C)(C)C)OC)N(C)C(=O)[C@@H](NC(=O)C1(NC(=O)OCC2c3ccccc3-c3ccccc32)CCCC1)C(C)C",
        "output": "133"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CCCN1CCC(N2CCN(Cc3ccccc3)CC2)CC1.CO.[H][H].[Pd]>>CCOC(=O)CCCN1CCC(N2CCNCC2)CC1",
        "output": "84"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].C[C@@H]1[C@H](NC(=O)OC(C)(C)C)CCCN1c1cnc(C#N)c(Cl)n1.Cl.Nc1ccc(C2CCN(C3CCCC3)CC2)cc1.O.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>C[C@@H]1[C@H](NC(=O)OC(C)(C)C)CCCN1c1cnc(C#N)c(Nc2ccc(C3CCN(C4CCCC4)CC3)cc2)n1",
        "output": "780"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrC(Br)(Br)Br.Cc1cc(CO)ccc1NC(=O)OC(C)(C)C.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(CBr)ccc1NC(=O)OC(C)(C)C",
        "output": "750"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc(OCCCN2C(=O)c3ccccc3C2=O)c(C#N)c1.ClB(Cl)Cl.ClCCl.O=C([O-])O.[I-].[Na+]>>N#Cc1cc(O)ccc1OCCCN1C(=O)c2ccccc2C1=O",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(C)cc(Oc2[nH]c(=O)[nH]c(=O)c2C(C)C)c1.Clc1cc(Cl)cc(CBr)c1>>Cc1cc(C)cc(Oc2c(C(C)C)c(=O)[nH]c(=O)n2Cc2cc(Cl)cc(Cl)c2)c1",
        "output": "389"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(Cc1cc(C(=O)O)no1)OC1CCCCO1.C[C@H](N)Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1>>CC(Cc1cc(C(=O)N[C@@H](C)Cn2ccc(-c3ccc(C#N)c(Cl)c3)n2)no1)OC1CCCCO1",
        "output": "696"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)[O-].Cc1cc(/C(F)=C/c2ccc(OC(F)(F)F)cc2)n[nH]1.Cc1ccc(CBr)cc1.[K+]>>Cc1ccc(Cn2nc(/C(F)=C/c3ccc(OC(F)(F)F)cc3)cc2C)cc1",
        "output": "635"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNC1.COc1ccc(S(=O)(=O)Cl)cc1[N+](=O)[O-].c1ccncc1>>COc1ccc(S(=O)(=O)N2CCCC2)cc1[N+](=O)[O-]",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(c1ccc(F)cc1)c1nc(-c2cn(Cc3ccc(C(F)(F)F)cc3)c3cc(F)c(F)cc3c2=O)no1.CO>>COc1cc2c(cc1F)c(=O)c(-c1noc(C(C)(C)c3ccc(F)cc3)n1)cn2Cc1ccc(C(F)(F)F)cc1",
        "output": "636"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cccc(B(O)O)c1.Cc1cc(Nc2cc3ccccc3c(Cl)n2)n[nH]1>>COc1cccc(-c2nc(Nc3cc(C)[nH]n3)cc3ccccc23)c1",
        "output": "865"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCc1cccn(-c2ccc([N+](=O)[O-])cc2OC)c1=O.[H][H].[Pd]>>CCCc1cccn(-c2ccc(N)cc2OC)c1=O",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1cc(C(=O)NCC2CCNCC2)ccc1Cl.C[N+](C)(C)C.O=C(O)C(F)(F)F.O=Cc1cc(-c2ccccc2)cs1>>COc1cc(C(=O)NCC2CCN(Cc3cc(-c4ccccc4)cs3)CC2)ccc1Cl",
        "output": "792"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCN(CC)CC.O=C(NCCC1CC1)c1ccc(Cl)nn1.O=C(c1ccc(F)cc1)C1CCNCC1>>O=C(NCCC1CC1)c1ccc(N2CCC(C(=O)c3ccc(F)cc3)CC2)nn1",
        "output": "406"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCOC(=O)c1ccc2c(n1)CCCC2N(CCc1cc(F)ccc1O)C(=O)OC(C)(C)C.FC(F)(F)c1ccc(CCc2ccc(CCl)cc2)cc1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1ccc2c(n1)CCCC2N(CCc1cc(F)ccc1OCc1ccc(CCc2ccc(C(F)(F)F)cc2)cc1)C(=O)OC(C)(C)C",
        "output": "49"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN.CN(C)C1CCc2oc3ccc(C(=O)Cl)cc3c2C1>>CCNC(=O)c1ccc2oc3c(c2c1)CC(N(C)C)CC3",
        "output": "271"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCc2c(n(C(=O)OCC(Cl)(Cl)Cl)c3ccccc23)C1.ClCCl.O=C(O)C(F)(F)F>>O=C(OCC(Cl)(Cl)Cl)n1c2c(c3ccccc31)CCNC2",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNOC.Cl.F[P-](F)(F)(F)(F)F.O.O=C(O)C1CCC(N(Cc2ccccc2)Cc2ccccc2)CC1>>CON(C)C(=O)C1CCC(N(Cc2ccccc2)Cc2ccccc2)CC1",
        "output": "54"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCc1ccc2ccccc2n1.O=C([O-])[O-].Oc1ccc(Br)cc1.[K+].[K+]>>Brc1ccc(OCc2ccc3ccccc3n2)cc1",
        "output": "616"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(CCO)CC1.CCCCCC.ClCCl.II.O.c1c[nH]cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCC(CCI)CC1",
        "output": "670"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(B(O)O)cc1.Nc1nc(Cl)cc(NC2CCCC2)n1>>COc1ccc(-c2cc(NC3CCCC3)nc(N)n2)cc1",
        "output": "884"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)OC(=O)C=C(CC(O)(C#C[Si](C)(C)C)C2CCCC2)O1.CO.[Cs+].[F-]>>C#CC(O)(CC1=CC(=O)OC(C)(C)O1)C1CCCC1",
        "output": "337"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(O)(C#C[Si](C)(C)C)c1cn[nH]c1.CO.O.O.[F-].[K+]>>C#CC(C)(O)c1cn[nH]c1",
        "output": "337"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(CO)CCc1ccccc1.CO.Cc1cccc(C2CC2)c1O.Cl.Oc1cc(Cl)nnc1Cl.[K+].[OH-]>>Cc1cccc(C2CC2)c1Oc1nnc(Cl)cc1O",
        "output": "603"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCc1cccc(CC)c1-c1ccc2c(n1)CCCC2=O.CO.[BH4-].[Na+]>>CCc1cccc(CC)c1-c1ccc2c(n1)CCCC2O",
        "output": "449"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1=C(C(=O)O)C(c2ccc(C(F)(F)F)cc2)CC(=O)N1.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Cl.ClCCCl.Nc1ccc2[nH]ncc2c1>>CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(C(F)(F)F)cc2)CC(=O)N1",
        "output": "170"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@H](N)CN.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)NC[C@H](C)N)cc1",
        "output": "43"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)c1ccncc1.CS(=O)(=O)Cl.Cl.ClCCl.NC1CCCOC1>>CS(=O)(=O)NC1CCCOC1",
        "output": "493"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccccc1.CC#N.O=C(O)c1ccc([N+](=O)[O-])cc1.O=C([O-])[O-].[K+].[K+]>>O=C(OCc1ccccc1)c1ccc([N+](=O)[O-])cc1",
        "output": "403"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OCCCCBr.CCN(CC)CC.Cc1ccccc1.Cl.FC(F)(F)c1c(Cl)cccc1N1CCNCC1.[K+].[OH-]>>CC(=O)OCCCCN1CCN(c2cccc(Cl)c2C(F)(F)F)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)OC(C)C.CCN1CCCC(N)C1.O=C(n1ccnc1)n1ccnc1.c1ccc(N2CCNCC2)cc1>>CCN1CCCC(NC(=O)N2CCN(c3ccccc3)CC2)C1",
        "output": "734"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C4(CC#N)CC(CO)(CO)C4)c3)ncnc21.NCCN.O=C(O)C(F)(F)F>>N#CCC1(n2cc(-c3ncnc4[nH]ccc34)cn2)CC(CO)(CO)C1",
        "output": "897"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.C1CCC2=NCCCN2CC1.CC(=O)SCC(CC(C)C)C(=O)O.Cc1ccccc1>>CC(=O)SCC(CC(C)C)C(=O)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCNCCO.COc1cc2[nH]ncc2cc1Nc1ncnc2sc3c(c12)CCC(C(=O)O)C3>>CCN(CCO)C(=O)C1CCc2c(sc3ncnc(Nc4cc5cn[nH]c5cc4OC)c23)C1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COC(=O)c1ccc(N2C3CCC2CC(OCc2c(-c4ccccc4OC(F)(F)F)noc2C2CC2)C3)c(F)c1.Cl.[K+].[OH-]>>O=C(O)c1ccc(N2C3CCC2CC(OCc2c(-c4ccccc4OC(F)(F)F)noc2C2CC2)C3)c(F)c1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)N(C)C.CCN(CC)CC.COC(=O)c1c(SCc2ccccc2)nc(Cl)nc1N1CCC(O)CC1.ClC(Cl)Cl.O=C(O)CC(O)(CC(=O)O)C(=O)O.c1cn2c(n1)CNCC2>>COC(=O)c1c(SCc2ccccc2)nc(N2CCn3ccnc3C2)nc1N1CCC(O)CC1",
        "output": "36"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)CC(c1ccccc1)c1ccccc1.CO.Cc1ccccc1.ClCCl.O.[H-]>>OCCC(c1ccccc1)c1ccccc1",
        "output": "225"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccccc1S(=O)(=O)NCc1cc(=O)c(OCc2ccccc2)c(C(=O)NC(C)C)n1C.Cn1c(C(N)S(=O)(=O)c2ccccc2)cc(=O)c(O)c1C(=O)O>>Cc1ccccc1S(=O)(=O)NCc1cc(=O)c(O)c(C(=O)NC(C)C)n1C",
        "output": "264"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CC[C@@H](Nc2cccc3nc(Nc4ccc(C#N)cc4)nn23)CC1.CC(C)(C)OC(=O)N[C@H]1CC[C@@H](Nc2cccc3nc(Nc4ccc(C(N)=O)cc4)nn23)CC1.CCO.O.O=C([O-])[O-].OO.[Cl-].[Na+].[Na+].[Na+]>>NC(=O)c1ccc(Nc2nc3cccc(N[C@H]4CC[C@@H](N)CC4)n3n2)cc1",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.Cc1ccccc1.Nc1ccc(C(=O)c2ccccc2)cc1.O>>CC(=O)Nc1ccc(C(=O)c2ccccc2)cc1",
        "output": "6"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc2nc(N)sc2c1.O=C(O)c1cccc(S(=O)(=O)N2CCCc3ccccc32)c1>>COc1ccc2nc(NC(=O)c3cccc(S(=O)(=O)N4CCCc5ccccc54)c3)sc2c1",
        "output": "918"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)NCC(=O)c1ccc(OC(=O)C2CCCC2)c(OC(=O)C2CCCC2)c1.O=C(Cl)C1CCCC1.O=C(Cl)C1CCCCC1>>CC(C)(C)NCC(O)c1ccc(OC(=O)C2CCCC2)c(OC(=O)C2CCCC2)c1",
        "output": "24"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCC.CCN(CC)CC.CCO.CCOC(=O)c1cccc(Sc2c(C3CC3)n(-c3cnn(COCC[Si](C)(C)C)c3)c3c(F)c(Cl)ccc23)c1F.Cl>>CCOC(=O)c1cccc(Sc2c(C3CC3)n(-c3cn[nH]c3)c3c(F)c(Cl)ccc23)c1F",
        "output": "813"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1cccc2c1CCN(Cc1ccc([C@H](C)NC(C)=O)cc1)C2.[Na+].[OH-]>>CC(=O)N[C@@H](C)c1ccc(CN2CCc3c(cccc3C(=O)O)C2)cc1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].Clc1nc2ccccc2nc1Cl.Nc1cccc2ccccc12.[K+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Clc1nc2ccccc2nc1Nc1cccc2ccccc12",
        "output": "780"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(N)C(=O)OCC(C)C.O=C(O)Cc1ccccc1>>CCC(NC(=O)Cc1ccccc1)C(=O)OCC(C)C",
        "output": "107"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CS(C)=O.N#Cc1ccccc1OCC1CO1.NCCCCOc1ccc(O)c(C(N)=O)c1.O>>N#Cc1ccccc1OCC(O)CNCCCCOc1ccc(O)c(C(N)=O)c1",
        "output": "16"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CN(C(=O)OC(C)(C)C)C(C)(C)CCCO[Si](C)(C)C(C)(C)C.[Cl-].[F-].[NH4+]>>CN(C(=O)OC(C)(C)C)C(C)(C)CCCO",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.Nc1ccc(Br)cc1Cl.O=C1CCC2(CC1)OCCO2.[Na+]>>Clc1cc(Br)ccc1NC1CCC2(CC1)OCCO2",
        "output": "469"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCI.CN(C)C=O.N#Cc1cc(O)ccc1Br.O.O=C([O-])[O-].[Cs+].[Cs+]>>CCOc1ccc(Br)c(C#N)c1",
        "output": "198"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(C(=O)CBr)cc1OC.Nc1ccccn1>>COc1ccc(-c2cn3ccccc3n2)cc1OC",
        "output": "508"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)Oc2ccncc2[C@@H](N2CCCC2=O)[C@@H]1O.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>CC1(C)Oc2cc[n+]([O-])cc2[C@@H](N2CCCC2=O)[C@@H]1O",
        "output": "262"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCc1ccccc1.CN(C)C=O.Cc1cc(O)cc(O)c1.O.O.[H-].[Na+]>>Cc1cc(O)cc(OCc2ccccc2)c1",
        "output": "127"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CO.Cc1ccc(OCc2ccccc2)c(-c2ccc3oc(=O)n(C(c4ccccc4)c4ccccc4)c3c2)c1.[Pd]>>Cc1ccc(O)c(-c2ccc3oc(=O)n(C(c4ccccc4)c4ccccc4)c3c2)c1",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(CO)CCl.Clc1cc(Cl)ncn1.[Cl-].[H-].[NH4+].[Na+]>>CC(C)(CCl)COc1cc(Cl)ncn1",
        "output": "653"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Sc2ccc3[nH]ncc3c2)C1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccccn1.ClCCl>>CC(C)(C)OC(=O)N1CCC(Sc2ccc3c(cnn3C(=O)OC(C)(C)C)c2)C1",
        "output": "841"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1c(C(N)=O)[nH]c2c(Br)cc(Cl)cc12.OB(O)c1ccc(Cl)cc1>>Cc1c(C(N)=O)[nH]c2c(-c3ccc(Cl)cc3)cc(Cl)cc12",
        "output": "833"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(Cl)c2c1.NC1CCNCC1>>Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(NC3CCNCC3)c2c1",
        "output": "78"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.CN(C)c1ccncc1.Cc1cc(OCCC(C)(C)O)cc(C)c1-c1cccc(COc2ccc(C=O)cc2)c1.ClC(Cl)Cl.c1ccncc1>>CC(=O)OC(C)(C)CCOc1cc(C)c(-c2cccc(COc3ccc(C=O)cc3)c2)c(C)c1",
        "output": "254"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COc1cc(C(=O)O)cc(C(F)(F)F)c1OCc1ccccc1.Cc1ccccc1.O=S(Cl)Cl>>COc1cc(C(=O)Cl)cc(C(F)(F)F)c1OCc1ccccc1",
        "output": "3"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#Cc1ccc(OC)cc1.CC#Cc1ccc(I)cc1.CCNCC.I[Cu]I>>CC#Cc1ccc(C#Cc2ccc(OC)cc2)cc1",
        "output": "664"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1=COCCC1.CC(C)(O)c1ccccc1Br.CCOCC.Cl>>CC(C)(OC1CCCCO1)c1ccccc1Br",
        "output": "141"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].CCOc1cc(Br)cc(F)c1OCC.O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>CCOc1cc(Br)c(Br)c(F)c1OCC",
        "output": "98"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CCOC(C)=O.CCOc1c(OC)cccc1C(O)c1cc(Cl)ccc1N.COc1ccc(C=O)c(OC)c1.[BH4-].[Na+]>>CCOc1c(OC)cccc1C(O)c1cc(Cl)ccc1NCc1ccc(OC)cc1OC",
        "output": "359"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=CCS[C@H]12)c1csc(NC=O)n1.CCOC(C)=O.COc1ccccc1.O.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>O=CNc1nc(C(=NOCC(=O)O)C(=O)NC2C(=O)N3C(C(=O)O)=CCS[C@H]23)cs1",
        "output": "278"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)CCCCCCCN(C(=O)c1ccccc1Cl)c1cccc(Cl)c1.[Na+].[OH-]>>O=C(O)CCCCCCCN(C(=O)c1ccccc1Cl)c1cccc(Cl)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCc1ccc(C#Cc2ccc(C(=O)OC)cc2)cc1.CO.O.[Li+].[OH-]>>CCCCc1ccc(C#Cc2ccc(C(=O)O)cc2)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCCCN(CCO)C(=O)CCOCCc1ccccc1.ClCCl>>CCCCN(CC=O)C(=O)CCOCCc1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(N)c1nccs1.O=C(O)c1ccc(C2CCOC2)c(-c2cccc(Cl)c2)n1>>CC(C)(NC(=O)c1ccc(C2CCOC2)c(-c2cccc(Cl)c2)n1)c1nccs1",
        "output": "137"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)Cc1ccc2nc(-c3cn(C)c4ccccc34)oc2c1.Cl.[Na+].[OH-]>>Cn1cc(-c2nc3ccc(CC(=O)O)cc3o2)c2ccccc21",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)c1ccc(OCC(=O)O)cc1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1ccc(N2CCN(C)CC2)c2c1CCNC2.ClCCl.F[P-](F)(F)(F)(F)F>>COc1ccc(N2CCN(C)CC2)c2c1CCN(C(=O)COc1ccc(C(C)C)cc1)C2",
        "output": "633"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(Cc1cccc(CCN)c1)C(=O)OC(C)(C)C.Cc1c(Cl)nc(Cl)c(=O)n1CC(=O)OCc1ccccc1>>Cc1c(Cl)nc(NCCc2cccc(CN(C)C(=O)OC(C)(C)C)c2)c(=O)n1CC(=O)OCc1ccccc1",
        "output": "148"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(C(=O)C[C@@H](c2ccc(C(=O)N(C)C)cc2)c2ccc(Cl)cc2C)ccn1.Cl.NO.O=C([O-])O.[Na+]>>Cc1cc(/C(C[C@@H](c2ccc(C(=O)N(C)C)cc2)c2ccc(Cl)cc2C)=N/O)ccn1",
        "output": "212"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)CCc1ccc(O)c(C)c1C.CCOC(=O)CCc1ccc(OCc2c(-c3ccc(CC)cc3)sc(C)c2C(F)(F)F)c(C)c1C.CCc1ccc(-c2sc(C)c(C(F)(F)F)c2CO)cc1>>CCc1ccc(-c2sc(C)c(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CN(CCO[Si](C)(C)C(C)(C)C)CC[C@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCC([C@@H](O)c4ccccc4-c4ccc(Cl)cc4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F.CO.Cl>>CN(CCO)CC[C@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCC([C@@H](O)c4ccccc4-c4ccc(Cl)cc4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F",
        "output": "708"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(N)n(C)n1.F[P-](F)(F)(F)(F)F.O=C(O)c1ccccc1Sc1ccc2nc(NC(=O)C3CC3)cn2n1>>Cc1cc(NC(=O)c2ccccc2Sc2ccc3nc(NC(=O)C4CC4)cn3n2)n(C)n1",
        "output": "917"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCC(C)=O.NC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C1.[Na+]>>CCC(C)NC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C1",
        "output": "236"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1cc(OC)ccc1Oc1cc(Cl)ccc1[N+](=O)[O-].Cl.[K+].[OH-]>>COc1ccc(Oc2cc(Cl)ccc2[N+](=O)[O-])c(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCC(CO)c1ccc(C(=O)NCCC(=O)OC)cc1.CCCCP(CCCC)CCCC.Cc1ccccc1.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1.Oc1ccc(-c2ccc(C(F)(F)F)cc2)cc1>>CCCCCCC(COc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)c1ccc(C(=O)NCCC(=O)OC)cc1",
        "output": "478"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CO.Cc1nc2cnc(Nc3ccnc(NCC(O)C(=O)O)n3)cc2n1C(C)C.Cl.On1nnc2ccccc21.[NH4+]>>Cc1nc2cnc(Nc3ccnc(NCC(O)C(N)=O)n3)cc2n1C(C)C",
        "output": "313"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CCCCCC(=O)Cl.Cl.NCc1nc(-c2ccc3c(c2)Nc2ccccc2S3)cs1>>CCCCCC(=O)NCc1nc(-c2ccc3c(c2)Nc2ccccc2S3)cs1",
        "output": "45"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)Cc1nnc(-c2nnn(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c2-c2ccccc2)n1Cc1ccccc1Cl.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCc1nnc(-c2nnn(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c2-c2ccccc2)n1Cc1ccccc1Cl",
        "output": "225"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].O=Cc1ccc(F)cc1Br.Oc1cccc(OCc2ccccc2)c1.[K+].[K+]>>O=Cc1ccc(Oc2cccc(OCc3ccccc3)c2)cc1Br",
        "output": "564"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.CCO.CO.Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=P([O-])([O-])[O-].O=S(=O)(Oc1ccc2ccc(-c3c4ccccc4c(-c4cccc5ccccc45)c4ccccc34)cc2c1)C(F)(F)F.OB(O)c1ccccc1.[K+].[K+].[K+].[Pd]>>c1ccc(-c2ccc3ccc(-c4c5ccccc5c(-c5cccc6ccccc56)c5ccccc45)cc3c2)cc1",
        "output": "825"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCNCC.CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.CO.C[Si](C)(C)Cl.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)C(O)c1ccccc1.O=C(O)CC(O)(CC(=O)O)C(=O)O.c1ccncc1>>CCN(CC)C(=O)C(O)c1ccccc1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C1(C)CCN(C2=NOC3(C2)CN(Cc2cc(C4CC4)c(-c4ccc(F)cc4)c(Cl)c2OC)C3)CC1.[Na+].[OH-]>>COc1c(CN2CC3(CC(N4CCC(C)(C(=O)O)CC4)=NO3)C2)cc(C2CC2)c(-c2ccc(F)cc2)c1Cl",
        "output": "281"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CO.FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1.O=C(O)C(F)(F)F.[BH3-]C#N.[Na+]>>CC(C)N1CCCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1",
        "output": "187"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)c1cc(NS(=O)(=O)c2ccccc2)n(-c2ccccc2)n1.Cc1ccccc1.Cl.[H-]>>O=S(=O)(Nc1cc(CO)nn1-c1ccccc1)c1ccccc1",
        "output": "391"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(=O)O[C@H](C)[C@@H](C(=O)N1CCCC1)N1CC2(CCCN2C(=O)OC(C)(C)C)C1=O.Cl>>CC(=O)O[C@H](C)[C@@H](C(=O)N1CCCC1)N1CC2(CCCN2)C1=O",
        "output": "634"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)c1ccncc1.Cl.ClCCl.F[P-](F)(F)(F)(F)F.N#CCN.O.O=C(O)c1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)CC2CCC1C2>>N#CCNC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)CC2CCC1C2",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.N#Cc1cc(-c2ncnc(Nc3ccc(N4CCNCC4)cc3)n2)ccc1OC1CCOCC1.O=C(O)CO>>N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C(=O)CO)CC4)cc3)n2)ccc1OC1CCOCC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)O)cc1.F[P-](F)(F)(F)(F)F.NC(Cc1ccccc1)[C@H](O)C(=O)NCc1ccccc1.O=C(O)C(F)(F)F>>COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)NC(Cc2ccccc2)[C@H](O)C(=O)NCc2ccccc2)cc1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCP(=O)=O.CCOC(C)=O.N#Cc1cc(N)n(-c2ccccc2)n1.O=C(O)c1cc(-c2ncccc2F)c(F)cc1Cl.c1ccncc1>>N#Cc1cc(NC(=O)c2cc(-c3ncccc3F)c(F)cc2Cl)n(-c2ccccc2)n1",
        "output": "917"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C=CCn1nc(-c2cccc(N)c2)c2c(c(Nc3ccc(I)cc3F)c(Cl)c(=O)n2C)c1=O.CC(=O)Cl.O>>C=CCn1nc(-c2cccc(NC(C)=O)c2)c2c(c(Nc3ccc(I)cc3F)c(Cl)c(=O)n2C)c1=O",
        "output": "9"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CN(C)c1ccccc1.Cc1cc(N2CCN(c3ccccc3)CC2)c(C#N)c(=O)[nH]1.O=P(Cl)(Cl)Cl>>Cc1cc(N2CCN(c3ccccc3)CC2)c(C#N)c(Cl)n1",
        "output": "100"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](C)(C)OCCC=O.CO.ClCCl.Cn1cc(C2=C(c3cccc(N)c3)C(=O)NC2=O)c2ccccc21.[BH3-]C#N.[Na+]>>Cn1cc(C2=C(c3cccc(NCCCO[Si](C)(C)C(C)(C)C)c3)C(=O)NC2=O)c2ccccc21",
        "output": "336"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)OC(C)C.CO.COc1cc(C)c(S(=O)(=O)N2CCCCC2COCC(=O)OC(C)(C)C)c(C)c1.[Na+].[OH-]>>COc1cc(C)c(S(=O)(=O)N2CCCCC2COCC(=O)O)c(C)c1",
        "output": "278"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.OC[C@H]1CC[C@H](CO)CC1>>CC(C)(C)[Si](C)(C)OC[C@@H]1CC[C@@H](CO)CC1",
        "output": "193"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.COC(=O)C(C)c1ccc2cc(O)ccc2c1.COCCl>>COCOc1ccc2cc(C(C)C(=O)OC)ccc2c1",
        "output": "375"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.CO.Cc1ccc(S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)OCc2ccccc2Cl)C(=O)OCc2ccccc2)cc1.ClC(Cl)Cl.[Na+].[OH-]>>Cc1ccc(S(=O)(=O)NC(=N)NCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)OCc2ccccc2Cl)C(=O)O)cc1",
        "output": "186"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CC(C)(C)c1ccc(Cl)c([N+](=O)[O-])c1.CCOC(C)=O.[H][H].[Pd]>>CCOC(=O)CC(C)(C)c1ccc(Cl)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1C(C(=O)Nc1ccccc1OCc1ccccc1)c1ccc2c(cnn2C)c1.[Pd]>>CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1C(C(=O)Nc1ccccc1O)c1ccc2c(cnn2C)c1",
        "output": "23"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)CCCCC(N)c1ccc2ccccc2c1.Cc1ccc(S(=O)(=O)Cl)cc1.O>>CCOC(=O)CCCCC(NS(=O)(=O)c1ccc(C)cc1)c1ccc2ccccc2c1",
        "output": "530"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N(C[C@H](O)c1cccc(Cl)c1)[C@H]1CCc2ccc(O)cc2C1.COc1ccc(B(O)O)cc1C=O.ClCCl.[Cu+2].c1ccncc1>>COc1ccc(Oc2ccc3c(c2)C[C@@H](N(C[C@H](O)c2cccc(Cl)c2)C(=O)OC(C)(C)C)CC3)cc1C=O",
        "output": "920"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(-c2ncccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CN)n1.FC(F)(F)c1ccc(Cl)nn1>>Cc1ccc(-c2ncccn2)c(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ccc(C(F)(F)F)nn2)n1",
        "output": "241"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(C=O)cc1O.Cc1cc(C)nc(C)c1.ClC(Cl)Cl.O=C(Cl)CCl>>COc1ccc(C=O)cc1OC(=O)CCl",
        "output": "111"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N(C[C@H](O)COc1ccccc1)C1CCCc2ccc(OCC(=O)O)cc2C1.CCCCNC.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.Cl.ClCCl>>CCCCN(C)C(=O)COc1ccc2c(c1)CC(N(C[C@H](O)COc1ccccc1)C(=O)OC(C)(C)C)CCC2",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(Cl)Cl.Cc1ccc2ccccc2c1.ClCCl.Cl[Ti](Cl)(Cl)Cl>>Cc1ccc2ccccc2c1C=O",
        "output": "591"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)O)cn1.Cl.N[C@@H]1CCCC[C@H]1O>>Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)N[C@@H]2CCCC[C@H]2O)cn1",
        "output": "674"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCc1ccccc1.Oc1ccc(Br)cc1F>>Fc1cc(Br)ccc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1cc(C2CC2)c2c(C)c(Cl)ccn2c1=O.Nc1cccc(B(O)O)c1>>COC(=O)c1cc(C2CC2)c2c(C)c(-c3cccc(N)c3)ccn2c1=O",
        "output": "947"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C(O)CCc1ccc(Cl)cc1.O=S(Cl)Cl.c1ccccc1>>O=C(Cl)CCc1ccc(Cl)cc1",
        "output": "53"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.CCOC(=O)CBr.N#Cc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)COc1ccc(C#N)cc1",
        "output": "123"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)CCCCCBr.Oc1cc(Cl)ccc1-c1nc2cc(F)c(F)cc2n1CC1CCCCC1>>CCOC(=O)CCCCCOc1cc(Cl)ccc1-c1nc2cc(F)c(F)cc2n1CC1CCCCC1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNC1.CC(C)(C)OC(=O)N1CCN(c2ccc(OCCCCl)cc2)C(=O)C1.CCC(C)=O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(c2ccc(OCCCN3CCCC3)cc2)C(=O)C1",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#Cc1ccccc1.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.I[Cu]I.Nc1ccc(I)cc1.O>>Nc1ccc(C#Cc2ccccc2)cc1",
        "output": "664"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)C=O.COc1ccccc1F.O.[Li]CCCC>>COc1cccc(C=O)c1F",
        "output": "239"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.C[C@H]1CNC[C@@H](C)O1.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[K+].[K+]>>C[C@H]1CN(c2ccc([N+](=O)[O-])cc2)C[C@@H](C)O1",
        "output": "26"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.O.O=C1CCC(=O)N1Br.O=c1ccc2ccc(Cl)cc2[nH]1>>O=c1[nH]c2cc(Cl)ccc2cc1Br",
        "output": "518"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(NS(=O)(=O)c1ccc(-c2ccccn2)s1)C(=O)O.CCN(CC)CC.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.C[Si](C)(C)CCON.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>CC(C)(NS(=O)(=O)c1ccc(-c2ccccn2)s1)C(=O)NOCC[Si](C)(C)C",
        "output": "480"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCN1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.Cc1c(Cl)cccc1S(=O)(=O)Nc1ncc(CC(=O)O)s1.ClCCl>>Cc1c(Cl)cccc1S(=O)(=O)Nc1ncc(CC(=O)N2CCOCC2)s1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)CCc1ccc(N)c(OC)c1.CN(C)C=O.CN(C)c1ccccn1.COc1cccc([C@H]2O[C@H](CC(=O)O)C(=O)N(CC(C)(C)COC(C)=O)c3ccc(Cl)cc32)c1OC.O.O=S(Cl)Cl>>CCOC(=O)CCc1ccc(NC(=O)C[C@H]2O[C@H](c3cccc(OC)c3OC)c3cc(Cl)ccc3N(CC(C)(C)COC(C)=O)C2=O)c(OC)c1",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cccc(OC)c1C1CCN(C(=O)c2c[nH]c3cc(Cl)ccc23)CC1.ClCc1ccncc1>>COc1cccc(OC)c1C1CCN(C(=O)c2cn(Cc3ccncc3)c3cc(Cl)ccc23)CC1",
        "output": "556"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOCC.CN1CCN(c2nc(-c3ccc(C(=O)NC4(C(=O)OCc5ccccc5)CCCCC4)cc3)cs2)CC1.[Na+].[OH-]>>CN1CCN(c2nc(-c3ccc(C(=O)NC4(C(=O)O)CCCCC4)cc3)cs2)CC1",
        "output": "186"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)[C@@H]1CC[C@@H](Oc2ccc3cc(C=O)ccc3c2)CC1.CC(Cl)Cl.CCOC(=O)CC(C)N.O=C([O-])O.[Na+].[Na+]>>CCOC(=O)CC(C)NCc1ccc2cc(O[C@@H]3CC[C@@H](C(C)(C)C)CC3)ccc2c1",
        "output": "468"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CC(C)(C)OC(=O)N(c1cc(N)cc(-c2cnc(N3CCCNC(=O)C3)s2)c1)c1nccc(C(F)(F)F)n1.CCN(CC)CC.CCOC(C)=O.ClCCl>>CC(=O)Nc1cc(-c2cnc(N3CCCNC(=O)C3)s2)cc(N(C(=O)OC(C)(C)C)c2nccc(C(F)(F)F)n2)c1",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCCCC1.Cc1ccc(CC(N)=O)c(CCc2nc(Nc3ccc(C4CCN(C(=O)OC(C)(C)C)CC4)cc3)ncc2C(F)(F)F)c1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(CC(N)=O)c(CCc2nc(Nc3ccc(C4CCNCC4)cc3)ncc2C(F)(F)F)c1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(F)c(COc2nsc(NC(=O)Oc3ccccc3)c2C(N)=O)c(F)c1.NCCCN1CCCC1>>Cc1cc(F)c(COc2nsc(NC(=O)NCCCN3CCCC3)c2C(N)=O)c(F)c1",
        "output": "488"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.OCCCCCCCCBr.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCCCCCCCBr",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.N.O=[N+]([O-])c1ccc2c(c1)N1CCCN=C1S2.[H][H].[Pd]>>Nc1ccc2c(c1)N1CCCN=C1S2",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)OB(c2ccc(C3(C(=O)NS(C)(=O)=O)CC3)cc2)OC1(C)C.COc1cc(Br)ccc1-c1onc(C)c1NC(=O)O[C@H](C)c1cccc(C(F)(F)F)c1>>COc1cc(-c2ccc(C3(C(=O)NS(C)(=O)=O)CC3)cc2)ccc1-c1onc(C)c1NC(=O)O[C@H](C)c1cccc(C(F)(F)F)c1",
        "output": "933"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(SCc3ccc(C(=O)O)cc3)c2CC1>>CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(SCc3ccc(CO)cc3)c2CC1",
        "output": "72"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCCC/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCCN=[N+]=[N-].CCOCC.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCCC/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCCN",
        "output": "89"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.COc1ccc2c3c4c(ccc3n(CCCN(C)C)c2c1)C(=O)CC4.O.O=C([O-])[O-].O=[N+]([O-])c1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-].[Na+].[Na+]>>COc1cc2c(cc1C(C)=O)c1c3c(ccc1n2CCCN(C)C)C(=O)CC3",
        "output": "31"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COc1cnc2ccc(=O)n(CCC3OCCO3)c2n1.Cl>>COc1cnc2ccc(=O)n(CCC=O)c2n1",
        "output": "740"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(O)C1CC1.O=S(=O)(Nc1ncc(Cl)nc1Cl)c1cccc(Cl)c1Cl>>CC(Oc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl)C1CC1",
        "output": "209"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.CN(C)CCCO.Cc1cc(O)ccc1-c1noc(-c2ccc(OC(C)C)c(Cl)c2)n1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(OCCCN(C)C)ccc1-c1noc(-c2ccc(OC(C)C)c(Cl)c2)n1",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.COc1ccc(-c2c3n(c4cc(OC)c(OC)cc24)CCNC3)cc1.ClCCl.c1ccncc1>>COc1ccc(-c2c3n(c4cc(OC)c(OC)cc24)CCN(C(C)=O)C3)cc1",
        "output": "369"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C1CCOC1.CC(C)(C)[Si](C)(C)OCc1cccc(CCCN2CCOCC2)n1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>OCc1cccc(CCCN2CCOCC2)n1",
        "output": "708"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC1(C)CCC(C)(C)C2CC=CC=C21.CC1(C)CCC(C)(C)c2cc([N+](=O)[O-])ccc21.O=S(=O)(O)O.O=[N+]([O-])O.[Fe]>>CC1(C)CCC(C)(C)c2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CCCc1ccccc1)C(=O)O.CCN=C=NCCCN(C)C.CN1CCOCC1.CNOC.Cl.Cl.ClCCl>>CON(C)C(=O)[C@H](CCCc1ccccc1)NC(=O)OC(C)(C)C",
        "output": "54"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1.Cl>>O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(C)(C)c1ccc([N+](=O)[O-])cc1Cl.[O-][Cl+2]([O-])O.[Zn]>>CC(C)(C)c1ccc(N)cc1Cl",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C#N)c1ccccc1C#C[Si](C)(C)C.Cl.[Na+].[OH-]>>C#Cc1ccccc1C(C)C#N",
        "output": "337"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CN.CN(C)C=O.CS(=O)(=O)Nc1ccc(-c2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)c3cccc(C(=O)O)c3)sc2Cl)cc1.ClCCCl.O.On1nnc2ccccc21>>CNC(=O)c1cccc(N(CCC(c2ccccc2)c2ccccc2)C(=O)Nc2nc(-c3ccc(NS(C)(=O)=O)cc3)c(Cl)s2)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1ccc(CBr)cc1.Cn1[nH]c(=O)c2c1[C@]1(C)CC[C@H]2C1(C)C>>COc1ccc(Cn2c(=O)c3c(n2C)[C@]2(C)CC[C@H]3C2(C)C)cc1",
        "output": "635"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.CO.COc1cc2c(cc1C)CCNC2C1(c2ccccc2Cl)CCC1.[BH3-]C#N.[Na+]>>COc1cc2c(cc1C)CCN(C)C2C1(c2ccccc2Cl)CCC1",
        "output": "69"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CNC(=O)c1c(OCc2ccccc2)c(=O)cc(CNS(=O)(=O)c2ccc(Cl)cc2)n1C.Cn1c(C(N)S(=O)(=O)c2ccccc2)cc(=O)c(O)c1C(=O)O>>CNC(=O)c1c(O)c(=O)cc(CNS(=O)(=O)c2ccc(Cl)cc2)n1C",
        "output": "264"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Cc1cc(Br)ccc1C(=O)O.ClCCl.NC1CC1.O.O=C(Cl)C(=O)Cl>>Cc1cc(Br)ccc1C(=O)NC1CC1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCCN2CCCCCC2=O)c1=O.C[C@@H](O)CN>>C[C@@H](O)CNC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCCN2CCCCCC2=O)c1=O",
        "output": "498"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)c1ccc(CCN2CCP(=O)(c3ccccc3)CC2)cc1.Cl>>O=C(O)c1ccc(CCN2CCP(=O)(c3ccccc3)CC2)cc1",
        "output": "752"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN1CCCC1=O.Clc1nc(-c2ccco2)c2scc(Br)c2n1.NCCO.O>>OCCNc1nc(-c2ccco2)c2scc(Br)c2n1",
        "output": "544"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(-c2ccc(C(=O)O)[nH]2)c1.Cl.Cl.ClCCl.NCCCO>>COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(-c2ccc(C(=O)NCCCO)[nH]2)c1",
        "output": "137"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1ccc2c(c1)CCN(C1CCNCC1)C(=O)N2.O=C(c1cc(Cl)ncn1)N1CCC2CCCCC21>>COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)N4CCC5CCCCC54)ncn3)CC1)C(=O)N2",
        "output": "162"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1ccc(C2CCN(C(=O)OC(C)(C)C)CC2O)cc1.COCCCN1C(=O)COc2ccc(CCl)cc21>>COCCCN1C(=O)COc2ccc(COC3CN(C(=O)OC(C)(C)C)CCC3c3ccc(C(=O)OC)cc3)cc21",
        "output": "208"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.CNCCOC.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2[nH]c(-c3nc4cscc4[nH]c3=O)cc2c1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>COCCN(C)C(=O)c1ccc2[nH]c(-c3nc4cscc4[nH]c3=O)cc2c1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CNOC.Cl.ClCCl.O=C(O)COCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1>>CON(C)C(=O)COCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1",
        "output": "54"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CC[C@@H](O)CC1.CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCOC(C)=O.CN(C)C=O.c1c[nH]cn1>>CC(C)(C)OC(=O)N[C@H]1CC[C@@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CC1",
        "output": "602"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNC1.CC#N.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COCC1CCN(c2nc(CC(=O)O)nc3scc(-c4ccccc4)c23)CC1.F[P-](F)(F)(F)(F)F>>COCC1CCN(c2nc(CC(=O)N3CCCC3)nc3scc(-c4ccccc4)c23)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Nc1ccc2nc(-c3ccc(C4CCCCC4)cc3)cc(O)c2c1.CCCCCC.COS(=O)(=O)OC.Cc1ccccc1>>COc1cc(-c2ccc(C3CCCCC3)cc2)nc2ccc(NC(C)=O)cc12",
        "output": "317"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.NC1CC1.O=S1(=O)N(CCOCCBr)c2ccccc2N1c1c(F)cccc1F>>O=S1(=O)N(CCOCCNC2CC2)c2ccccc2N1c1c(F)cccc1F",
        "output": "147"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OCCc1cnc2c(-c3ccc(Sc4ccccc4)cc3)cnn2c1O.CO.[Na+].[OH-]>>OCCc1cnc2c(-c3ccc(Sc4ccccc4)cc3)cnn2c1O",
        "output": "225"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C#N)c1ccc(O)c(N)c1.O=C(Cl)c1ccc(Cl)cc1.c1ccncc1>>CC(C#N)c1ccc(O)c(NC(=O)c2ccc(Cl)cc2)c1",
        "output": "11"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCOc2ccc(O)cc2)cs1.CC(C)=O.Clc1ccc(CBr)cc1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)C(C)(C)Sc1nc(CCOc2ccc(OCc3ccc(Cl)cc3)cc2)cs1",
        "output": "127"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C(=O)Oc1ccc(Cl)cc1)[C@@H]1CC[C@@H](CO)CC1.CN(C)c1ccncc1.CS(=O)(=O)Cl.ClCCl.O.c1ccncc1>>CN(C(=O)Oc1ccc(Cl)cc1)[C@@H]1CC[C@@H](COS(C)(=O)=O)CC1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1cc([N+](=O)[O-])ccc1N1CCOCCC1=O.[Ni]>>Cc1cc(N)ccc1N1CCOCCC1=O",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C1Nc2ccc(OCCCCSc3ccc(C4CCCCC4)cc3)cc2C(C2CCCCC2)(C2CCCCC2)O1.OO>>O=C1Nc2ccc(OCCCCS(=O)c3ccc(C4CCCCC4)cc3)cc2C(C2CCCCC2)(C2CCCCC2)O1",
        "output": "199"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccccc1CNC(=O)c1cc(C(F)(F)F)nn1-c1cccc(CNC(=O)OC(C)(C)C)c1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>COc1ccccc1CNC(=O)c1cc(C(F)(F)F)nn1-c1cccc(CN)c1",
        "output": "793"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Cl.NC[C@@H]1CC[C@@H](C(=O)O)CC1.O>>CC(C)(C)OC(=O)NC[C@@H]1CC[C@@H](C(=O)O)CC1",
        "output": "631"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NCCCCCCCCCCC(=O)N1CCC(c2nc(N)nc3ccccc23)CC1.Cl>>NCCCCCCCCCCC(=O)N1CCC(c2nc(N)nc3ccccc23)CC1",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.O.O=C(O)COc1ccc([C@@H]2CCC(=O)C2)cc1.O=C(n1ccnc1)n1ccnc1.[NH4+].[OH-]>>NC(=O)COc1ccc([C@@H]2CCC(=O)C2)cc1",
        "output": "313"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.C[Si](C)(C)C=[N+]=[N-].Cc1noc(-c2ccc(-c3ccc(CC(=O)O)cc3)cc2)c1NC(=O)OC(C)c1ccccc1Cl.c1ccccc1>>COC(=O)Cc1ccc(-c2ccc(-c3onc(C)c3NC(=O)OC(C)c3ccccc3Cl)cc2)cc1",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCc1nc(C)n(CC2CN(Cc3ccccc3)CCO2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCCc1nc(C)n(CC2CN(Cc3ccccc3)CCO2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.COCCn1cc(C(=O)O)c2c(OC(F)(F)F)ccc(F)c21.Cl.ClCCl.O=C(NCc1ccc(F)c(C2CCNCC2)c1)C(F)(F)F>>COCCn1cc(C(=O)N2CCC(c3cc(CNC(=O)C(F)(F)F)ccc3F)CC2)c2c(OC(F)(F)F)ccc(F)c21",
        "output": "256"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1cc2c(C)c(C)cc(NS(=O)(=O)c3cccs3)c2[nH]1.CO.O=C(O)CC(O)(CC(=O)O)C(=O)O.[K+].[OH-]>>Cc1cc(NS(=O)(=O)c2cccs2)c2[nH]c(C(=O)O)cc2c1C",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCc2c(cccc2C(=N)N2CCOCC2)C1.ClCCl.O=C(O)C(F)(F)F>>N=C(c1cccc2c1CCNC2)N1CCOCC1",
        "output": "887"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CS(C)=O.F[P-](F)(F)(F)(F)F.Nc1ccc(Br)cc1N>>CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)Nc1cc(Br)ccc1N",
        "output": "563"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(COc2ccccc2)cc1Nc1ccc(F)cc1.[Na+].[OH-]>>O=C(O)c1ccc(COc2ccccc2)cc1Nc1ccc(F)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.Cl.O=[N+]([O-])c1cc2c(Nc3ccc(OCc4ccccn4)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1.[Fe].[Na+].[OH-]>>Nc1cc2c(Nc3ccc(OCc4ccccn4)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.O=C([O-])[O-].OCCI.[K+].[K+].c1cc2[nH]ncc2cc1OC1CCCNC1>>OCCN1CCCC(Oc2ccc3[nH]ncc3c2)C1",
        "output": "184"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc2nc(-c3cccs3)ccc2c1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>BrCc1ccc2nc(-c3cccs3)ccc2c1",
        "output": "29"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN.CCOC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CN4CCN(C)CC4)cc3)ncc2c1=O.CO>>CCNC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CN4CCN(C)CC4)cc3)ncc2c1=O",
        "output": "498"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.CCOc1cc(O)ccc1CCC(=O)OC.CCOc1nn(-c2ccc(C(F)(F)F)cc2)cc1CCCO.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CCOc1cc(OCCCc2cn(-c3ccc(C(F)(F)F)cc3)nc2OCC)ccc1CCC(=O)O",
        "output": "928"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.C[C@@H](O)[C@H](N)C(=O)O.O=S(Cl)Cl>>COC(=O)[C@@H](N)[C@@H](C)O",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCN[C@H]1CCc2c(O)cccc2C1.CCOCC.O.O=C(Cl)OCc1ccccc1.O=C([O-])O.[Na+]>>CCCN(C(=O)OCc1ccccc1)[C@H]1CCc2c(O)cccc2C1",
        "output": "427"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(c1ccc(Cl)nn1)C1CC(C)(C)NC(C)(C)C1.COc1cc2ncccc2cc1B(O)O.O>>COc1cc2ncccc2cc1-c1ccc(N(C)C2CC(C)(C)NC(C)(C)C2)nn1",
        "output": "866"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(C=C(C#N)S(=O)(=O)c2ccccc2)cc1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>N#CC(=Cc1ccc(CBr)cc1)S(=O)(=O)c1ccccc1",
        "output": "29"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCn1ccc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3COC(C)=O)cn(C)c2=O)n1.ClCCl.O>>CCn1ccc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3CO)cn(C)c2=O)n1",
        "output": "348"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.COc1nccc(Cl)c1-c1nc2cc3c(cc2[nH]1)C(=O)N(C(C)C)C3=O.Cl>>CC(C)N1C(=O)c2cc3nc(-c4c(Cl)cc[nH]c4=O)[nH]c3cc2C1=O",
        "output": "758"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2nc3c(oc4ccc(Br)cc43)c(=O)[nH]2)CC1.CC(C)(C)OC(=O)N1C[C@@H](F)C[C@H]1c1nc2c(oc3ccc(Br)cc32)c(=O)[nH]1.O=c1[nH]c(C2CCNCC2)nc2c1oc1ccc(Br)cc12>>O=c1[nH]c([C@@H]2C[C@H](F)CN2)nc2c1oc1ccc(Br)cc12",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(C)[Si](Oc1ccc2c(C3CC3)n[nH]c2c1)(c1ccccc1)c1ccccc1.CCN(CC)CC.CN(C)c1ccncc1>>CC(C)(C)OC(=O)n1nc(C2CC2)c2ccc(O[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)cc21",
        "output": "841"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.Cl.Nc1cc(O)ccc1O.O.O=C(Cl)CCl.OCCNCCO>>O=C(CCl)Nc1cc(O)ccc1O",
        "output": "9"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C(NCCO)c1ccc2cncc(Br)c2n1.OB(O)c1cccc(O)c1>>O=C(NCCO)c1ccc2cncc(-c3cccc(O)c3)c2n1",
        "output": "871"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC1CCN(CC2CCn3c(=O)ccc4ccc(=O)n2c43)CC1.CO.Cl.ClCCl>>NC1CCN(CC2CCn3c(=O)ccc4ccc(=O)n2c43)CC1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CSC4CCCCC4)cc2)CCO3)cc1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=S([O-])([O-])=S.[Na+].[Na+]>>Cc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CS(=O)C4CCCCC4)cc2)CCO3)cc1",
        "output": "13"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCN=C=NCCCN(C)C.CCOc1ccc(C(=O)CCC(=O)O)cc1OCC.Nc1cc(-c2ccccc2)c(Cc2ccc(Br)cc2)s1.On1nnc2ccccc21>>CCOc1ccc(C(=O)CCC(=O)Nc2cc(-c3ccccc3)c(Cc3ccc(Br)cc3)s2)cc1OCC",
        "output": "882"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CO.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cccc([N+](=O)[O-])c1Cl>>COC(=O)c1cccc([N+](=O)[O-])c1Cl",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.C1CCOC1.CCCC(C(=O)OC)c1c(C)nc(-c2ccccc2)nc1Cl.O=C([O-])O.[Na+]>>CCCC(C(=O)OC)c1c(C)nc(-c2ccccc2)nc1N1CCCCC1",
        "output": "162"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1CCN(c2ccc3nc(N)c(C#N)c(O)c3c2)CC1.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>CN1CCN(c2ccc3nc(N)c(C#N)c(Cl)c3c2)CC1",
        "output": "177"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=C(O)c1ccc2[nH]ccc2c1.O=[N+]([O-])c1ccc(CCN2CCNCC2)cc1>>O=C(c1ccc2[nH]ccc2c1)N1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COC(=O)c1cc(NS(C)(=O)=O)ccc1/C=C/c1cc(-n2ccc(=O)[nH]c2=O)cc(C(C)(C)C)c1OC.Cl.[Na+].[OH-]>>COc1c(/C=C/c2ccc(NS(C)(=O)=O)cc2C(=O)O)cc(-n2ccc(=O)[nH]c2=O)cc1C(C)(C)C",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1ccc(OC[C@@H]2CCCN2C(=O)OC(C)(C)C)cc1.CO.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCC[C@H]1COc1ccc(C(=O)O)cc1",
        "output": "386"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCOc1ccccc1-c1ncc(C(=O)O)c(=O)[nH]1.CCCOc1ccc(OC)cc1-c1ncc(C(=O)OCC)c(=O)[nH]1>>CCCOc1ccc(OC)cc1-c1ncc(C(=O)O)c(=O)[nH]1",
        "output": "171"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cc1cccc(C(=O)Cc2ccnc(-c3ccc(C(=O)O)cc3)c2)n1.ClCCl.NC1CCOCC1>>Cc1cccc(C(=O)Cc2ccnc(-c3ccc(C(=O)NC4CCOCC4)cc3)c2)n1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.N#CCN1CCCCC1CO.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCCN1CCCCC1CO",
        "output": "246"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.CS(=O)(=O)c1cc(Br)ccc1[N+](=O)[O-].[Zn]>>CS(=O)(=O)c1cc(Br)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.C[C@@](CCn1ccc(-c2ccc(OC3CCC(O)CC3)cc2)cc1=O)(C(=O)NOC1CCCCO1)S(C)(=O)=O.Cl>>C[C@@](CCn1ccc(-c2ccc(OC3CCC(O)CC3)cc2)cc1=O)(C(=O)NO)S(C)(=O)=O",
        "output": "915"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCC(Oc1ccc(Cl)c(C(F)(F)F)c1)C(=O)Cl.CCN(CC)CC.Cc1ccccc1.NCc1ccncc1>>CCC(Oc1ccc(Cl)c(C(F)(F)F)c1)C(=O)NCc1ccncc1",
        "output": "45"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.Cc1cn(COCC[Si](C)(C)C)c2nccc(Nc3ccc([N+](=O)[O-])cc3F)c12.O=[Pt-]>>Cc1cn(COCC[Si](C)(C)C)c2nccc(Nc3ccc(N)cc3F)c12",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(-c2cccc([N+](=O)[O-])c2C)cn1.Cl.c1ccncc1>>Cc1c(-c2ccc(=O)[nH]c2)cccc1[N+](=O)[O-]",
        "output": "758"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1ccc(CCC(=O)O)cc1.Cl.O.O=C(n1ccnc1)n1ccnc1.[BH4-].[Na+]>>COC(=O)c1ccc(CCCO)cc1",
        "output": "231"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1nc2cc(C(C(C)C)n3ccnc3)ccc2[nH]c1=O.O=S(=O)(O)O.[Na+].[OH-]>>CC(C)C(c1ccc2[nH]c(=O)c(C(=O)O)nc2c1)n1ccnc1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(C)=O.I.Nc1cccc2c(=O)n(C3CC3)ccc12.O=C([O-])[O-].O=N[O-].[Na+].[Na+].[Na+]>>O=c1c2cccc(I)c2ccn1C1CC1",
        "output": "200"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)Cc1cn2c(C(=O)NCC34CC5CC(CC(C5)C3)C4)cccc2n1.CO.O.[Na+].[OH-]>>O=C(O)Cc1cn2c(C(=O)NCC34CC5CC(CC(C5)C3)C4)cccc2n1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=C(Cl)c1ccccc1.O=C1Cc2ccccc2N1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C1Cc2cc(C(=O)c3ccccc3)ccc2N1",
        "output": "61"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1nnn(Cc2cc(C(F)(F)F)ccc2/C=C/C(=O)O)n1.Cc1nonc1CN1CCNCC1>>Cc1nnn(Cc2cc(C(F)(F)F)ccc2/C=C/C(=O)N2CCN(Cc3nonc3C)CC2)n1",
        "output": "811"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.COC(=O)c1cc(C(F)(F)F)cc([N+](=O)[O-])c1C.[Cl-].[Fe].[NH4+]>>COC(=O)c1cc(C(F)(F)F)cc(N)c1C",
        "output": "481"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.Cc1cc(OCCC(=O)O)ccc1[SiH](C(C)C)C(C)C.Cl.ClCCl.NCc1ccccc1>>Cc1cc(OCCC(=O)NCc2ccccc2)ccc1[SiH](C(C)C)C(C)C",
        "output": "599"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(O)CN.CCCCc1noc(C)c1/C=C/c1ccc(C(=O)OC)cn1>>CCCCc1noc(C)c1/C=C/c1ccc(C(=O)NCC(C)(C)O)cn1",
        "output": "862"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCO.Cc1cc(N)nnc1Cl.O.[Na]>>CCCOc1nnc(N)cc1C",
        "output": "407"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)O.ClCCl.O=C(NCCOc1ccc(-c2nc(-c3ccccc3)cs2)cc1)OCc1ccccc1.[Na+].[OH-]>>NCCOc1ccc(-c2nc(-c3ccccc3)cs2)cc1",
        "output": "574"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)CCC(=O)N1CC(C(=O)OCC)C(c2ccc(NC(=O)Cc3ccc(NC(=O)Nc4ccccc4C)c(OC)c3)cc2)C1.[Na+].[OH-]>>COc1cc(CC(=O)Nc2ccc(C3CN(C(=O)CCC(=O)O)CC3C(=O)O)cc2)ccc1NC(=O)Nc1ccccc1C",
        "output": "255"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)[C@H](C(=O)O)CC[C@]1(C)C(=O)O.CO.O.O=S(Cl)Cl.[Na+].[OH-]>>COC(=O)[C@@H]1CC[C@](C)(C(=O)O)C1(C)C",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccccn1.CC#N.O.O=C([O-])[O-].O=Cc1cccc(B(O)O)c1F.[K+].[K+]>>O=Cc1cccc(-c2ccccn2)c1F",
        "output": "869"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOc1c(C(C)=O)cc(Cl)c(F)c1C(CO[Si](C)(C)C(C)(C)C)N=[N+]=[N-].O.O.[Cl-].[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOc1c(C(C)=O)cc(Cl)c(F)c1C(N)CO[Si](C)(C)C(C)(C)C",
        "output": "562"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)N1CCN(c2ccncc2)CC1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)N1CCN(c2ccncc2)CC1",
        "output": "431"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CS(=O)(=O)Nc1ccc(C(=O)Cl)cc1.CS(=O)(=O)Nc1ccc2c(c1)OCCNCCO2.c1ccncc1>>CS(=O)(=O)Nc1ccc(C(=O)N2CCOc3ccc(NS(C)(=O)=O)cc3OCC2)cc1",
        "output": "201"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C)=O.Cl.Clc1cc(N2CCC2)ncn1.Nc1ccc(C(=O)O)cc1.O>>O=C(O)c1ccc(Nc2cc(N3CCC3)ncn2)cc1",
        "output": "161"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)n1nnc(-c2ccc(OCc3ccccc3)cc2)n1.CO.[C].[Pd]>>CC(C)n1nnc(-c2ccc(O)cc2)n1",
        "output": "23"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC.COS(=O)(=O)OC.Cc1cc2c(c(O)c1C=O)C(C)(C)CCC2(C)C.ClCCl.O.[Cl-].[Na+].[OH-]>>COc1c(C=O)c(C)cc2c1C(C)(C)CCC2(C)C",
        "output": "317"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C#N)c1cc(C(=O)O)ccn1.CN(C)C=O.Cc1ccc(N)cc1B1OC(C)(C)C(C)(C)O1.ClCCCl.O.On1nnc2cccnc21>>Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1B1OC(C)(C)C(C)(C)O1",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.Cl[Sn]Cl.O.O.O.O=C([O-])O.O=[N+]([O-])c1cnc(-c2ccc(OCc3ccccc3)c(C34CC5CC(CC(C5)C3)C4)c2)nc1.[Na+].[Na+].[OH-]>>Nc1cnc(-c2ccc(OCc3ccccc3)c(C34CC5CC(CC(C5)C3)C4)c2)nc1",
        "output": "660"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ncc(Br)cc1Br.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>BrCc1ncc(Br)cc1Br",
        "output": "590"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCc2cc([N+](=O)[O-])ccc21.CO.[Pd]>>CC(C)(C)OC(=O)N1CCc2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(O)c1cccc2c(Br)cccc12.OB(O)c1ccncc1>>O=C(O)c1cccc2c(-c3ccncc3)cccc12",
        "output": "904"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CC#N.CC(C)(C)C(=O)Nc1cccc(C(=O)c2ccc3ncc(Cl)nc3c2)c1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)C(=O)Nc1cccc(C(=O)c2ccc3ncc(N4CCOCC4)nc3c2)c1",
        "output": "505"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)CCCCC(N)=S.Cl.O.[BH4-].[Ca+2].[Cl-].[Cl-].[Na+]>>NC(=S)CCCCCO",
        "output": "343"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCNCCc1ccccn1.COc1ccc(N2CCOCC2)c2sc(NC(=O)c3ccnc(Br)c3)nc12.O=C([O-])[O-].[Cs+].[Cs+]>>CCN(CCc1ccccn1)c1cc(C(=O)Nc2nc3c(OC)ccc(N4CCOCC4)c3s2)ccn1",
        "output": "647"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.CS(=O)(=O)n1cc(C2CCN(C(=O)OCc3ccccc3)CC2)c2cc(C#N)ccc21.[Pd]>>CS(=O)(=O)n1cc(C2CCNCC2)c2cc(C#N)ccc21",
        "output": "428"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.FB(F)F.O.O=C(O)[C@@H]1CO[C@@](CI)(c2ccc(F)cc2F)C1.[BH4-].[Na+]>>OC[C@@H]1CO[C@@](CI)(c2ccc(F)cc2F)C1",
        "output": "231"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN1CCCNCC1.Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(CC3CC3)cc(C=O)c2c1.ClCCl.[Na+]>>Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(CC3CC3)cc(CN3CCCN(C)CC3)c2c1",
        "output": "757"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCSc1ccc(Br)cc1.O=C=O.[Li]CCCC>>CCCCSc1ccc(C(=O)O)cc1",
        "output": "654"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.CC(C)(CO)[N+](=O)[O-].CCN(CC)CC.ClCCl>>CC(=O)OCC(C)(C)[N+](=O)[O-]",
        "output": "254"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCS(=O)(=O)c1ccc(CN)cc1.Cc1c(C(=O)O)cc(-c2ccc(S(=O)(=O)NC(C)(C)C)c(C(F)(F)F)c2)n1CC1CCCCC1>>CCS(=O)(=O)c1ccc(CNC(=O)c2cc(-c3ccc(S(=O)(=O)NC(C)(C)C)c(C(F)(F)F)c3)n(CC3CCCCC3)c2C)cc1",
        "output": "790"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)c1cccc(N)c1.CCN=C=NCCCN(C)C.ClCCl.O.O=C(O)c1cccnc1Br.O=C([O-])O.[Na+]>>CC(C)(C)c1cccc(NC(=O)c2cccnc2Br)c1",
        "output": "739"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)COc1ccc(OCc2sc(-c3ccc(C(F)(F)F)cc3)nc2CC)c(C)c1.Cl.[Li+].[OH-]>>CCc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc(OCC(=O)O)cc1C",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCC1CCCN1.Nc1cccc(F)n1.O>>CCC1CCCN1c1cccc(N)n1",
        "output": "756"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1cn2c(n1)-c1cc(Br)c(F)cc1C1CC2C1.[Na+].[OH-]>>O=C(O)c1cn2c(n1)-c1cc(Br)c(F)cc1C1CC2C1",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NCCCCCCCCO.CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCCCCCCCCNC(=O)OC(C)(C)C)cc1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.C[Si](C)(C)CCOCn1ncc2cc([N+](=O)[O-])ccc21.[Pd]>>C[Si](C)(C)CCOCn1ncc2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.FC(F)(F)c1ccc(N2CCNCC2)cc1.O=S(=O)(Cl)c1cccc(CBr)c1>>O=S(=O)(c1cccc(CBr)c1)N1CCN(c2ccc(C(F)(F)F)cc2)CC1",
        "output": "99"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.Cc1ccc2c(c1)c1c(n2CC(CC(=O)O)c2ccncc2)CCN(C)C1.ClCCl.F[P-](F)(F)(F)(F)F.[Cl-].[NH4+].c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>Cc1ccc2c(c1)c1c(n2CC(CC(N)=O)c2ccncc2)CCN(C)C1",
        "output": "313"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.C[Si](C)(C)C#Cc1cc2ccccc2o1.O.O=C([O-])[O-].[K+].[K+]>>C#Cc1cc2ccccc2o1",
        "output": "337"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "B.C1CCOC1.C1CCOC1.CO.O=C(O)CCc1cc(Cl)ccc1Br>>OCCCc1cc(Cl)ccc1Br",
        "output": "231"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C1CCOC1.CC(=O)N(C)C.CC1(C(=O)O)CC1.CCOC(C)=O.CN(C)C=O.Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(N)cn4n3)ccc2C)n(C)n1.Cl.O=C(Cl)C(=O)Cl.O=C([O-])O.[Na+]>>Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5(C)CC5)cn4n3)ccc2C)n(C)n1",
        "output": "692"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCn1c(=O)c(CSc2ccc(C)cc2)nc2ccccc21.O.O.O=S([O-])OO.[K+]>>CCn1c(=O)c(CS(=O)(=O)c2ccc(C)cc2)nc2ccccc21",
        "output": "730"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1ccc(-c2ccc(Br)cc2)cc1.C1CCOC1.COB(OC)OC.Cl.O.[Li]CCCC>>OB(O)c1ccc(-c2ccc(Br)cc2)cc1",
        "output": "789"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)CC[C@@H]12.CO.O.O=C(Cl)c1ccccc1.c1ccncc1>>CC(=O)Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](OC(=O)c3ccccc3)CC[C@@H]12",
        "output": "51"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrBr.CCO.COc1cccc2c1CC(NC(C1CC1)C1CC1)CC2.ClCCl>>COc1ccc(Br)c2c1CC(NC(C1CC1)C1CC1)CC2",
        "output": "98"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(C)C=O.Cc1ccc(Br)cc1NC(=O)c1nc[nH]c1C(=O)Nc1nc2cc(N3CCNCC3)ccc2[nH]1.Cl.Cl.[Na+]>>Cc1ccc(Br)cc1NC(=O)c1nc[nH]c1C(=O)Nc1nc2cc(N3CCN(C)CC3)ccc2[nH]1",
        "output": "217"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nc1nc(N)c2c(N3CCNCC3)cccc2n1.O=C(Cl)c1ccc2c(c1)OCO2>>Nc1nc(N)c2c(N3CCN(C(=O)c4ccc5c(c4)OCO5)CC3)cccc2n1",
        "output": "201"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.CC(C)=CCC[C@@H](C)C/C=C/C(C)O.c1ccncc1>>CC(=O)OC(C)/C=C/C[C@H](C)CCC=C(C)C",
        "output": "155"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[O-].CCOC(C)=O.COCCN(Cc1ccc(-c2cc3nccc(Cl)c3s2)nc1)C(=O)OC(C)(C)C.CS(C)=O.Cl.ClCCl.Nc1ccc(O)cc1F.O.[K+]>>COCCN(Cc1ccc(-c2cc3nccc(Oc4ccc(N)c(F)c4)c3s2)nc1)C(=O)OC(C)(C)C",
        "output": "936"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)c1ccncc1.COc1cc2c(cc1NS(C)(=O)=O)C(=O)N(CC(=O)O)C2=O.ClCCCl.ClCCl.[O-][n+]1cc(Cl)c(C[C@H](O)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1>>COc1cc2c(cc1NS(C)(=O)=O)C(=O)N(CC(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC3CC3)c1)C2=O",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "NC[C@H]1CC[C@@H](COc2ccccn2)CC1.O=C(O)c1cn[nH]c1>>O=C(NC[C@H]1CC[C@@H](COc2ccccn2)CC1)c1cn[nH]c1",
        "output": "621"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.N#Cc1nc(Cl)c(NCCO)nc1N.O.c1ccncc1>>CC(=O)OCCNc1nc(N)c(C#N)nc1Cl",
        "output": "254"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C=CCOC(=O)Nc1ccn([C@@H]2O[C@H](CO)[C@@H](OC(=O)OCC=C)C2(F)F)c(=O)n1.CN(C)c1ccncc1.COCCOC.O=C(O)CCc1ccccc1>>C=CCOC(=O)Nc1ccn([C@@H]2O[C@H](COC(=O)CCc3ccccc3)[C@@H](OC(=O)OCC=C)C2(F)F)c(=O)n1",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.ClCCl.O=C([O-])O.OCc1csc2cncn12.[Na+]>>CC(=O)OCc1csc2cncn12",
        "output": "254"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.COc1cccc(CNc2nccc(-c3cc(N4CCNCC4)c4cc(OC)ccc4c3)n2)c1.Cl.Cl.Cl.O.O=C([O-])[O-].OCCCBr.[K+].[K+]>>COc1cccc(CNc2nccc(-c3cc(N4CCN(CCCO)CC4)c4cc(OC)ccc4c3)n2)c1",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)O.COC(=O)C1CN(CCc2cc(F)cc(-c3cnc(-c4ccc(OC(C)C)c(Cl)c4)s3)c2OC)C1.O.[Na+].[OH-]>>COc1c(CCN2CC(C(=O)O)C2)cc(F)cc1-c1cnc(-c2ccc(OC(C)C)c(Cl)c2)s1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CO.C[Si](C)(C)C#Cc1cnc(NCc2ccc(-c3ccc4ncnc(N)c4c3)s2)c(C(=O)NCc2ccc(F)c(F)c2)c1.O=C([O-])[O-].[K+].[K+]>>C#Cc1cnc(NCc2ccc(-c3ccc4ncnc(N)c4c3)s2)c(C(=O)NCc2ccc(F)c(F)c2)c1",
        "output": "337"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCc1ccc(N)c(C(=O)O)c1.CO.O=S(Cl)Cl>>CCCCc1ccc(N)c(C(=O)OC)c1",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.O=C1CCC(=O)N1I.O=[N+]([O-])c1c(F)cc(F)cc1NCc1ccc(-c2ccccc2)cc1>>O=[N+]([O-])c1c(NCc2ccc(-c3ccccc3)cc2)cc(F)c(I)c1F",
        "output": "834"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCCC.COC(=O)C(O)(c1ccccc1)c1ccccc1.OC1CCN(Cc2ccccc2)C1.[H-].[Na+]>>O=C(OC1CCN(Cc2ccccc2)C1)C(O)(c1ccccc1)c1ccccc1",
        "output": "289"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCc1cc(O)cc(C)c1OCc1ccccc1.Cl.ClC(Cl)Cl.O=C(Cl)c1ccccc1>>CCc1cc(OC(=O)c2ccccc2)cc(C)c1OCc1ccccc1",
        "output": "482"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CNS(=O)(=O)Cc1ccc2[nH]cc(CCCOS(C)(=O)=O)c2c1.COc1cncnc1N1CCNCC1.[I-].[K+]>>CNS(=O)(=O)Cc1ccc2[nH]cc(CCCN3CCN(c4ncncc4OC)CC3)c2c1",
        "output": "496"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.Cc1cc(C(=O)O)ccc1Br.ClCCl.[K+]>>Cc1cc(C(=O)O)ccc1B1OC(C)(C)C(C)(C)O1",
        "output": "942"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CO.NS(=O)(=O)c1cc(C(=O)O)ccc1Cl.O=S(=O)(O)O>>COC(=O)c1ccc(Cl)c(S(N)(=O)=O)c1",
        "output": "195"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2nccc3c2ccn3Cc2ccccc2)CC1.CCO.Cl>>c1ccc(Cn2ccc3c(C4CCNCC4)nccc32)cc1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCOC(=O)c1cnc(Cl)cc1-c1ccccc1Cl.O.[Na+].[OH-]>>O=C(O)c1cnc(Cl)cc1-c1ccccc1Cl",
        "output": "171"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Br.O.OCCc1ccc(O)cc1>>Oc1ccc(CCBr)cc1",
        "output": "224"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.ClCCl.Cn1nc(-c2ccccc2O)ccc1=O.O=S(=O)(N(c1ccccc1)S(=O)(=O)C(F)(F)F)C(F)(F)F>>Cn1nc(-c2ccccc2OS(=O)(=O)C(F)(F)F)ccc1=O",
        "output": "843"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COc1ccc(Cl)c(N)c1Cl.O=C(O)c1cc(-c2cccc(F)c2)ccc1F.O=S(Cl)Cl.[H-].[Na+]>>COc1ccc(Cl)c(NC(=O)c2cc(-c3cccc(F)c3)ccc2F)c1Cl",
        "output": "50"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)COc1ccccc1C.ClC(Cl)Cl.O=S(=O)(O)Cl>>CCOC(=O)COc1ccc(S(=O)(=O)Cl)cc1C",
        "output": "182"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCc1cc(Cl)nc(Cl)n1.Cc1ccc(N)cc1.O.O=C([O-])[O-].[Cs+].[Cs+]>>CCc1cc(Nc2ccc(C)cc2)nc(Cl)n1",
        "output": "161"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)N.CCc1cc(C=Cc2ccccc2OCC2CO2)on1>>CCc1cc(C=Cc2ccccc2OCC(O)CNC(C)(C)C)on1",
        "output": "16"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCc1c(-c2cc(=O)c3c(O)cc(OCC(=O)OCC)cc3o2)ccc(OC)c1O.CN(C)C=O.[H][H].[Pd]>>CCCc1c(-c2cc(=O)c3c(O)cc(OCC(=O)OCC)cc3o2)ccc(OC)c1O",
        "output": "116"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)I.CN(C)C=O.O.O=C([O-])[O-].O=Cc1cccc(O)c1.[K+].[K+]>>CC(C)Oc1cccc(C=O)c1",
        "output": "318"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NC[C@@H]1[C@H]2C[C@H]2CN1C(=O)c1nc(N)sc1-c1cccc(F)c1.O=C(O)c1cccc2c1OCCO2>>Nc1nc(C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2cccc3c2OCCO3)c(-c2cccc(F)c2)s1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "N#Cc1cc(Br)c2c(c1)cc1n2CCNC1=O.OCc1ccc(B(O)O)cc1>>N#Cc1cc(-c2ccc(CO)cc2)c2c(c1)cc1n2CCNC1=O",
        "output": "833"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1c(C)nc(CC(C)C)c(CN)c1-c1ccc(C)cc1>>COC(=O)c1c(C)nc(CC(C)C)c(CNC(=O)OC(C)(C)C)c1-c1ccc(C)cc1",
        "output": "631"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CI.CN(C)C=O.CN1C(=O)C2(N=C1N)c1cc(Br)ccc1O[C@@H]1CC(O)CC[C@H]12.O=C([O-])[O-].[Cs+].[Cs+]>>COC1CC[C@@H]2[C@@H](C1)Oc1ccc(Br)cc1C21N=C(N)N(C)C1=O",
        "output": "140"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1ccc([N+](=O)[O-])c(Oc2cccc(Cl)c2)c1.CCO.O.[Cl-].[Fe].[NH4+]>>CC(=O)c1ccc(N)c(Oc2cccc(Cl)c2)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.C[C@H](N)c1nc2ccccc2n1-c1ccccc1.Nc1nccc(Cl)n1>>C[C@H](Nc1ccnc(N)n1)c1nc2ccccc2n1-c1ccccc1",
        "output": "166"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2[nH]ncc2c1.Fc1ccc(CBr)cc1.N.[H-].[Na+]>>Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(cnn2Cc2ccc(F)cc2)c1",
        "output": "635"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)N[C@@H]1CCCC[C@H]1Nc1nc(Cl)ncc1Cl.Nc1ccc2c(c1)C1CCC2CN(C(=O)C(F)(F)F)C1>>CS(=O)(=O)N[C@@H]1CCCC[C@H]1Nc1nc(Nc2ccc3c(c2)C2CCC3CN(C(=O)C(F)(F)F)C2)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCCNC(=S)NC(=O)c1ccccc1.[Na+].[OH-]>>CC(C)(C)OC(=O)NCCNC(N)=S",
        "output": "80"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)/C=C/C(=O)c1nn(-c2cccc(S(C)(=O)=O)c2)ccc1=O.NNc1cccc(Cl)c1>>CS(=O)(=O)c1cccc(-n2ccc(=O)c(-c3ccnn3-c3cccc(Cl)c3)n2)c1",
        "output": "984"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC1(C)CCNc2ccc(CCCCl)cc21.CCN(CC)CC>>CC(=O)N1CCC(C)(C)c2cc(CCCCl)ccc21",
        "output": "315"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1ccc(-c2cnco2)cc1.C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.[Fe+2].[K+].[Na+].[OH-].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc(-c3cnco3)cc2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1ccc(-c2ccccc2[N+](=O)[O-])cc1.[Pd]>>Cc1ccc(-c2ccccc2N)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)c1c(-c2ccc(OC)cc2)c2cc(OC)c(OC)cc2n1CCO.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>COC(=O)c1c(-c2ccc(OC)cc2)c2cc(OC)c(OC)cc2n1CCOS(=O)(=O)c1ccc(C)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#Cc1cccc(S(=O)(=O)CCC)c1.CC(C)(C)OC(=O)COc1ncc(Cl)cc1Br.CCOC(C)=O.Cl[Pd]Cl.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCS(=O)(=O)c1cccc(C#Cc2cc(Cl)cnc2OCC(=O)OC(C)(C)C)c1",
        "output": "719"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C(=O)c1cc2c(s1)-c1ccccc1OCC2)c1ccc(C(=O)O)cc1Cl.CNC.Cl>>CN(C)C(=O)c1ccc(N(C)C(=O)c2cc3c(s2)-c2ccccc2OCC3)c(Cl)c1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CCN(CC)CC.Cc1c(C)c2ccc(OCCCC=O)nc2[nH]c1=O.Cl.Clc1cccc(N2CCNCC2)c1Cl.O.[Na+]>>Cc1c(C)c2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nc2[nH]c1=O",
        "output": "484"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.O=C[O-].O=[N+]([O-])c1ccc2c(c1)N(S(=O)(=O)c1ccc(F)cc1)C[C@H](CO)O2.[NH4+]>>Nc1ccc2c(c1)N(S(=O)(=O)c1ccc(F)cc1)C[C@H](CO)O2",
        "output": "202"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.CCCn1nc(-c2ccc(OC)cc2)c2cccc(N3CCOCC3)c21>>CCCn1nc(-c2ccc(O)cc2)c2cccc(N3CCOCC3)c21",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.Cl.F[P-](F)(F)(F)(F)F.NCC1CN2CCC1CC2.O=C(O)c1n[nH]c2ccc(OC(F)(F)F)cc12>>O=C(NCC1CN2CCC1CC2)c1n[nH]c2ccc(OC(F)(F)F)cc12",
        "output": "816"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.N#Cc1cnc(C(F)F)c(C(=O)O)c1.[Cl-].[NH4+]>>N#Cc1cnc(C(F)F)c(C(N)=O)c1",
        "output": "704"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C(Br)C1CC1.CN(C)C=O.O.O=C([O-])[O-].Oc1cccc2ccccc12.[K+].[K+]>>CCOC(=O)C(Oc1cccc2ccccc12)C1CC1",
        "output": "455"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COCOc1c(C(=O)O)ccnc1OCc1ccccc1.NCc1ccc(F)cc1>>COCOc1c(C(=O)NCc2ccc(F)cc2)ccnc1OCc1ccccc1",
        "output": "753"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)O.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CNOC.Cl.ClCCl.F[B-](F)(F)F>>CON(C)C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C",
        "output": "54"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.CCCNCCC.CCc1nc(C#N)c(C#N)nc1Cl.O>>CCCN(CCC)c1nc(C#N)c(C#N)nc1CC",
        "output": "505"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCO.C[C@H](N)c1cc2cc(Cl)c(F)cc2[nH]c1=O.Cl.O=C(Nc1ccnc(Cl)n1)C1CC1>>C[C@H](Nc1nccc(NC(=O)C2CC2)n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O",
        "output": "544"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCC(C(=O)OC)c1c(C)nc(NCC(C)(C)C)nc1-c1ccc(C)cc1.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc(NCC(C)(C)C)nc1-c1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(Cl)c2c1.NCCOCCN>>Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(NCCOCCN)c2c1",
        "output": "78"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Br[Cu]Br.C1COCCOCCOCCOCCOCCO1.C=Cc1c(C(=O)OC)nc(-c2ccc(N)cc2)c(F)c1N.CC#N.CCOCC.ClCCl.F[B-](F)(F)F.N#[O+].[Br-].[Cu]Br.[K+].c1cnc2c(c1)ccc1cccnc12>>C=Cc1c(C(=O)OC)nc(-c2ccc(Br)cc2)c(F)c1N",
        "output": "373"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCc1cc(Oc2cccc(CNC(=O)c3ccc(C(F)(F)F)cc3F)c2)ccc1CCC(=O)OC.[Li+].[OH-]>>CCc1cc(Oc2cccc(CNC(=O)c3ccc(C(F)(F)F)cc3F)c2)ccc1CCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=S(=O)(c1ccccc1)n1cc(-c2ccc3nc(CC4CCNCC4)oc3c2)c2ccc(F)cc21.O=S(=O)(c1ccccc1)n1cc(I)c2ccc(F)cc21>>Fc1ccc2c(-c3ccc4nc(CC5CCNCC5)oc4c3)c[nH]c2c1",
        "output": "771"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.O=C(N(Cc1ccnc2ccccc12)[C@H]1CCN[C@H](Cc2ccccc2)C1)C(F)(F)F.O=C(O)c1cccc(Br)c1.O=S(Cl)Cl>>O=C(c1cccc(Br)c1)N1CC[C@H](N(Cc2ccnc3ccccc23)C(=O)C(F)(F)F)C[C@H]1Cc1ccccc1",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cl[Pd]Cl.O=Cc1ccc(Br)cc1F.[Fe+2].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc(C=O)c(F)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#Cc1ccnc(-c2cc(N)c(C#C[Si](C)(C)C)cc2[N+](=O)[O-])c1.CO.ClCCl.O.O=C([O-])[O-].[K+].[K+]>>C#Cc1ccnc(-c2cc(N)c(C#C)cc2[N+](=O)[O-])c1",
        "output": "337"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.C[Si](C)(C)Cl.Cc1[nH]c2ccc(C(=O)O)cc2c1Sc1ccc(Cl)cc1>>COC(=O)c1ccc2[nH]c(C)c(Sc3ccc(Cl)cc3)c2c1",
        "output": "33"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NC1CCN(C(=O)N2CCCC2)CC1.ClCCl.O=C(O)C(F)(F)F>>NC1CCN(C(=O)N2CCCC2)CC1",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.O.O=CO.OC1(c2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)CCCc2ccccc21>>OC1(c2c[nH]cn2)CCCc2ccccc21",
        "output": "838"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CCBr.CN(C)C=O.OCCc1ccc(F)cc1.[H-].[Na+]>>C=CCOCCc1ccc(F)cc1",
        "output": "120"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1Cc2ccc(C3CCNCC3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1.CS(=O)(=O)Cl.Cl.Cl.Cl.Cl.Cl>>CC1Cc2ccc(C3CCN(S(C)(=O)=O)CC3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1",
        "output": "584"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CCc2nc(Nc3cc(-c4ccnc(N5CCn6c7c(c(F)c6C5=O)CCCC7)c4C=O)cn(C)c3=O)sc2C1.CO.[BH4-].[Na+]>>CN1CCc2nc(Nc3cc(-c4ccnc(N5CCn6c7c(c(F)c6C5=O)CCCC7)c4CO)cn(C)c3=O)sc2C1",
        "output": "476"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COc1cc(C(F)(F)F)ccc1C=O.[Cl-].[Li+]>>O=Cc1ccc(C(F)(F)F)cc1O",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CO.COC(=O)c1ccc2c(c1)[nH]c(=O)n2Cc1ccc2ccc(C#N)cc2c1.Cl.[Li+].[OH-]>>N#Cc1ccc2ccc(Cn3c(=O)[nH]c4cc(C(=O)O)ccc43)cc2c1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "ClC(Cl)Cl.Cn1cc(-c2cnc3nnn(Cc4c[nH]c5ncccc45)c3n2)cn1.O=C1CCC(=O)N1Br.c1cc2cc(Cn3nnc4ncc(-c5cnn(CCOC6CCCCO6)c5)nc43)ccn2n1>>OCCn1cc(-c2cnc3nnn(Cc4ccn5nccc5c4)c3n2)cn1",
        "output": "543"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCC(C(=O)OC)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc2ccccc2c1.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc2cc(C(C)(C)C)nn2c1-c1ccc2ccccc2c1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.COC(=O)c1cnc(Cl)cn1.Cc1c(-c2ccc(F)cc2)nnc(N2CCN[C@H](C)C2)c1C>>COC(=O)c1cnc(N2CCN(c3nnc(-c4ccc(F)cc4)c(C)c3C)C[C@H]2C)cn1",
        "output": "505"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)CC(NC(=O)N1CCOCC1)C(=O)NC1(C#N)CCNCC1.CN1CCOCC1.Cl.ClCCl.O=C=Nc1ccccc1>>CC(C)(C)CC(NC(=O)N1CCOCC1)C(=O)NC1(C#N)CCN(C(=O)Nc2ccccc2)CC1",
        "output": "323"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1ccc([N+](=O)[O-])cc1C#N.CCO.O=C[O-].[NH4+].[Pd]>>CC(C)(C)OC(=O)Nc1ccc(N)cc1C#N",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCNC(=O)C1.CCOC(C)=O.CN(C)CCN.Cc1ccccc1.Fc1ccc(Br)cc1.[Cu]I>>CC(C)(C)OC(=O)N1CCN(c2ccc(F)cc2)C(=O)C1",
        "output": "809"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CNCCCCc1ccccc1.c1ccc(-c2cnc(C3CO3)o2)nc1>>CN(CCCCc1ccccc1)CC(O)c1ncc(-c2ccccn2)o1",
        "output": "76"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN(C)C=O.COc1ccc(Oc2cc(Cl)nc(SC)n2)c(Cl)c1.Cl.Cl.NCc1nc2ccccc2[nH]1.O.O>>COc1ccc(Oc2cc(NCc3nc4ccccc4[nH]3)nc(SC)n2)c(Cl)c1",
        "output": "166"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.CS(=O)(=O)c1nc(-c2cc(F)cc3[nH]ccc23)cc(N2CCOCC2)n1.OCc1cccnc1.[H-].[Na+]>>Fc1cc(-c2cc(N3CCOCC3)nc(OCc3cccnc3)n2)c2cc[nH]c2c1",
        "output": "667"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)c1ccc(NC(=O)C(C2CCCCC2)n2c(-c3ccc(Cl)cc3)nc3cc(F)c(F)cc32)cc1.COC(=O)c1ccc(N)c(C(F)(F)F)c1.O=C(O)C(C1CCCCC1)n1c(-c2ccc(Cl)cc2)nc2ccccc21>>COC(=O)c1ccc(NC(=O)C(C2CCCCC2)n2c(-c3ccc(Cl)cc3)nc3ccccc32)c(C(F)(F)F)c1",
        "output": "710"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)c1cccc([C@H](C)N)c1.COC(=O)[C@H](C)Oc1cc(Cl)cc(Cn2c(C)c(C)c3cc(C(=O)O)ccc32)c1.Cl>>COC(=O)[C@H](C)Oc1cc(Cl)cc(Cn2c(C)c(C)c3cc(C(=O)N[C@@H](C)c4cccc(C(C)C)c4)ccc32)c1",
        "output": "753"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.C=CCC1CC(=O)c2ccccc2N1C(=O)OCc1ccccc1.Cc1cccc(C)n1.O.O=[Os](=O)(=O)=O.[Na+].[O-][I+3]([O-])([O-])[O-]>>O=CCC1CC(=O)c2ccccc2N1C(=O)OCc1ccccc1",
        "output": "571"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(F)C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCl.F[P-](F)(F)(F)(F)F.Nc1cc(Oc2cc(F)c(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)cc2F)ccn1>>CC(C)(F)C(=O)Nc1cc(Oc2cc(F)c(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)cc2F)ccn1",
        "output": "368"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.COc1ccc2c(c1C1=CCN(C(=O)OC(C)(C)C)CC1)OCC2=O.[Pd]>>COc1ccc2c(c1C1CCN(C(=O)OC(C)(C)C)CC1)OCC2=O",
        "output": "806"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.COc1ccc(-c2ncnc3c(C(=O)N[C@H]4CC[C@@H](N)CC4)c[nH]c23)c(OCC2CC2)c1>>COc1ccc(-c2ncnc3c(C(=O)N[C@H]4CC[C@@H](NC(C)=O)CC4)c[nH]c23)c(OCC2CC2)c1",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.Cc1ccc(N2CCNCC2)c(C)c1.O=C(Cl)c1ccc(I)cc1.[Na+].[OH-]>>Cc1ccc(N2CCN(C(=O)c3ccc(I)cc3)CC2)c(C)c1",
        "output": "201"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(-c2cc(O)no2)cc1.Cl.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>Oc1ccc(-c2cc(O)no2)cc1",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1=COCCC1.CCOCC.Cc1ccccc1S(=O)(=O)O.O.O=C([O-])O.Oc1ccccc1C(F)(F)F.[Na+]>>FC(F)(F)c1ccccc1OC1CCCCO1",
        "output": "319"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>C#CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc(C)c(N2CCNCC2)c1.O=C(O)[C@H](CO)NS(=O)(=O)c1ccccc1>>Cc1ccc(C)c(N2CCN(C(=O)[C@H](CO)NS(=O)(=O)c3ccccc3)CC2)c1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.ClCCl.O=[N+]([O-])c1ccc(S(=O)(=O)N2CCC(F)CC2)cc1.[BH4-].[Na+].[Ni]>>Nc1ccc(S(=O)(=O)N2CCC(F)CC2)cc1",
        "output": "401"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.COc1cc(NCCC(C)C)ccc1[N+](=O)[O-].[H][H].[Pd]>>COc1cc(NCCC(C)C)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.COC(=O)c1cccc2c1nc(C(=O)NC1CCN(C(C)C)CC1)n2CC(=O)Nc1ccc(Cl)cn1.ClCCl.O.[Na+].[OH-]>>CC(C)N1CCC(NC(=O)c2nc3c(C(=O)O)cccc3n2CC(=O)Nc2ccc(Cl)cn2)CC1",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.ClCCCCc1nnnn1C1CCCCC1.O=C([O-])[O-].O=C1CCc2cc(O)ccc2N1.O=S([O-])[O-].[K+].[K+].[Na+].[Na+]>>O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CC[C@H](Oc2ncnc3c2CNCC3)C1.CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CCOC(C)=O.COc1ncc(Br)cc1Cl.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>COc1ncc(N2CCc3ncnc(O[C@H]4CCN(C(=O)OC(C)(C)C)C4)c3C2)cc1Cl",
        "output": "597"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1ccc2c(-c3cc(Nc4ccc(S(N)(=O)=O)cc4)n[nH]3)csc2c1.NS(=O)(=O)c1ccc(Nc2cc(-c3csc4c(-c5cccc(O)c5)cccc34)[nH]n2)cc1.O>>NS(=O)(=O)c1ccc(Nc2cc(-c3csc4cc(O)ccc34)[nH]n2)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(CN)n1C.Cc1nc(-n2ccc(OCc3ccccc3)cc2=O)sc1C(=O)O>>Cc1nc(-n2ccc(OCc3ccccc3)cc2=O)sc1C(=O)NCc1ccc(C)n1C",
        "output": "534"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCCCCCCCCCC[C@@H](O)CC(=O)OC.CCOCC.Cl.O.O.[Li+].[OH-]>>CCCCCCCCCCC[C@@H](O)CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "N#Cc1ccc(C(=O)O)nc1.NC1=N[C@](CF)(c2cc(N)ccc2F)[C@@H](F)CO1>>N#Cc1ccc(C(=O)Nc2ccc(F)c([C@@]3(CF)N=C(N)OC[C@@H]3F)c2)nc1",
        "output": "985"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCN(C(C)C)C(C)C.Cc1ccc(N2CCc3ncnc(Cl)c3C2)c(C#N)c1.Cc1ncc([C@@H](C)N)cn1>>Cc1ccc(N2CCc3ncnc(N[C@H](C)c4cnc(C)nc4)c3C2)c(C#N)c1",
        "output": "110"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCc1ccc(O)cc1.CN(C)C=O.Cn1c(Cl)nc(-c2ccncn2)cc1=O.O.[H-].[Na+]>>CCCCCCc1ccc(Oc2nc(-c3ccncn3)cc(=O)n2C)cc1",
        "output": "542"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)NC(=O)[C@@H]1CC[C@H](Nc2cc(N3CCOCC3)ncc2[N+](=O)[O-])CC1.CCO.CCOC(C)=O.[Pd]>>CC(C)NC(=O)[C@H]1CC[C@@H](Nc2cc(N3CCOCC3)ncc2N)CC1",
        "output": "269"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN1CCOCC1.COc1ccc(OC)c2c1CC1=C(O2)C(=O)N([C@@H](CC2CCCCC2)C(=O)O)C1.F[P-](F)(F)(F)(F)F.Nc1ccccn1.O>>COc1ccc(OC)c2c1CC1=C(O2)C(=O)N([C@@H](CC2CCCCC2)C(=O)Nc2ccccn2)C1",
        "output": "368"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)CCc1cc(F)c(OCc2c(Cl)nsc2-c2ccc(Cl)cc2)c(F)c1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)CCc1cc(F)c(OCc2c(Cl)nsc2-c2ccc(Cl)cc2)c(F)c1",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1CCCO1.CCN(C(C)C)C(C)C.CCNC(=O)Nc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C3CCC(C(=O)O)CC3)s2)c1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C([O-])O.[Cl-].[NH4+].[Na+]>>CCNC(=O)Nc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc(C3CCC(C(N)=O)CC3)s2)c1",
        "output": "313"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCOC(=O)c1cc(N)no1.O.[Li+].[OH-]>>Nc1cc(C(=O)O)on1",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].COc1cccc2c1C[C@@H](N1CCCC1)CC2.[Na+]>>COc1ccc(Br)c2c1C[C@@H](N1CCCC1)CC2",
        "output": "98"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CC[C@H](C)N.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cn1nc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)c2ccc(F)cc21.F[P-](F)(F)(F)(F)F>>CC[C@H](C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(F)ccc34)nc12",
        "output": "737"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNC1.ClCCl.O=C(O)c1ccc(S(=O)(=O)Cl)cc1>>O=C(O)c1ccc(S(=O)(=O)N2CCCC2)cc1",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(C)n1nc(-c2cc(-c3ncnn3C)c(Cl)nc2-c2ccccc2)ccc1=O.ClC(Cl)Cl.N.O>>CC(C)n1nc(-c2cc(-c3ncnn3C)c(N)nc2-c2ccccc2)ccc1=O",
        "output": "388"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=C(O)CCc1cnoc1-c1ccc(F)cc1F.O=S(=O)(O)O>>COC(=O)CCc1cnoc1-c1ccc(F)cc1F",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.FC(F)(Cl)c1nnc2ccc(Cl)nn12.c1ccc(C2CCCNCC2)cc1>>FC(F)(Cl)c1nnc2ccc(N3CCCC(c4ccccc4)CC3)nn12",
        "output": "406"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CCBr.CC1(C)CC(Nc2nccc(-c3cc4ccc(O)cc4s3)n2)CC(C)(C)N1.CN(C)C=O.O.[H-].[Na+]>>C=CCOc1ccc2cc(-c3ccnc(NC4CC(C)(C)NC(C)(C)C4)n3)sc2c1",
        "output": "77"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1ccc(Br)cc1.CS(C)=O.Nc1ncccc1-c1ccc(O)cc1.O=C(O)c1ccccn1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>CCc1ccc(Oc2ccc(-c3cccnc3N)cc2)cc1",
        "output": "238"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(=O)Cl.Cc1[nH]c2c(-c3cc(C(F)F)ccc3OCC3CC3)ncnc2c1C(=O)N[C@H]1CC[C@H](N)C[C@@H]1C.Cl>>CCC(=O)N[C@H]1CC[C@H](NC(=O)c2c(C)[nH]c3c(-c4cc(C(F)F)ccc4OCC4CC4)ncnc23)[C@@H](C)C1",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1ccc2cccnc2c1[N+](=O)[O-].Cl.Cl[Sn]Cl>>CC(C)c1ccc2cccnc2c1N",
        "output": "269"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC1CCC(=O)CC1.O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CNC1.[Na+]>>CC1CCC(N2CC(NC(=O)CNc3ncnc4ccc(C(F)(F)F)cc34)C2)CC1",
        "output": "187"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CO.CS(=O)(=O)c1ccc(-c2ccc(OCC3CCNCC3)cn2)cc1.ClCCl.N#CBr.[Na+]>>CS(=O)(=O)c1ccc(-c2ccc(OCC3CCN(C#N)CC3)cn2)cc1",
        "output": "532"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Br.C1CCOC1.CCN=C=NCCCN(C)C.CN(C)C=O.CNC.Cl.O=C(O)c1ccc2nc(C(=O)c3ccccc3)cn2c1.On1nnc2ccccc21>>CN(C)C(=O)c1ccc2nc(C(=O)c3ccccc3)cn2c1",
        "output": "256"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)CC(=O)Cl.CC(O)c1ccc([C@H]2C[C@@]3(C)[C@@H](CC[C@@]3(O)C(F)(F)C(F)(F)F)[C@@H]3CCC4=CC(=O)CCC4=C23)cc1>>CC(OC(=O)CC(C)(C)C)c1ccc([C@H]2C[C@@]3(C)[C@@H](CC[C@@]3(O)C(F)(F)C(F)(F)F)[C@@H]3CCC4=CC(=O)CCC4=C23)cc1",
        "output": "126"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)C1CN(C(=O)OCc2ccccc2)C2CCN(C(=O)OC(C)(C)C)C12.ClCCl.O=C(O)C(F)(F)F>>COC(=O)C1CN(C(=O)OCc2ccccc2)C2CCNC12",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C(NCc1cccs1)C1(CCCCBr)c2ccccc2-c2ccccc21.c1ccc2nc(N3CCNCC3)ccc2c1>>O=C(NCc1cccs1)C1(CCCCN2CCN(c3ccc4ccccc4n3)CC2)c2ccccc2-c2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)c1cc([N+](=O)[O-])c(NC)cc1N1CCC(C(F)(F)F)CC1.[Ni]>>CCOC(=O)c1cc(N)c(NC)cc1N1CCC(C(F)(F)F)CC1",
        "output": "481"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](O)CCc1cccc2oc(-c3ccc(Cl)cc3)nc12.ClCCl>>C[C@H](O[Si](C)(C)C(C)(C)C)[C@H](CCc1cccc2oc(-c3ccc(Cl)cc3)nc12)OS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)OC(C)C.COc1ccccc1.ClCCl.O=C(Cc1ccccc1)N[C@@H]1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(OS(=O)(=O)C(F)(F)F)CS[C@H]12.O=C(O)C(F)(F)F>>O=C(Cc1ccccc1)N[C@@H]1C(=O)N2C(C(=O)O)=C(OS(=O)(=O)C(F)(F)F)CS[C@H]12",
        "output": "228"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)CCC(NC(=O)C1(NC(=O)OC(C)(C)C)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1.CO.Cl.ClCCl>>CN(C)CCC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1",
        "output": "431"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.Cc1ccccc1.O=C(Cl)c1ccccc1.OC1CCN(Cc2ccc(Br)cc2)CC1>>O=C(OC1CCN(Cc2ccc(Br)cc2)CC1)c1ccccc1",
        "output": "51"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.O=C1CCc2ccc(O)cc21.OCCCF.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C1CCc2ccc(OCCCF)cc21",
        "output": "478"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.C[Si](C)(C)CCOCn1cc(-n2ccc(=O)c(Cc3cccc(-c4ncc(OCc5ccccc5)cn4)c3)n2)cn1.ClCCl.[Pd]>>C[Si](C)(C)CCOCn1cc(-n2ccc(=O)c(Cc3cccc(-c4ncc(O)cn4)c3)n2)cn1",
        "output": "492"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.COc1ccc2[nH]cc(CCCCOS(=O)(=O)c3ccc(C)cc3)c2c1.Cc1cc2c(=O)n(-c3ccc(N4CCNCC4)cc3)ccc2o1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>COc1ccc2[nH]cc(CCCCN3CCN(c4ccc(-n5ccc6oc(C)cc6c5=O)cc4)CC3)c2c1",
        "output": "429"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCc1nc2nc(Cl)nc(C)c2[nH]1.CCO.CN>>CCCc1nc2nc(NC)nc(C)c2[nH]1",
        "output": "544"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(C#N)cc1B(O)O.COc1ccccc1B(O)O.Cc1cc(Cl)ccc1C1c2c(cc(Br)n2C(C)C)C(=O)N1c1cc(Cl)c(=O)n(C)c1.Cc1ccc(Cl)cc1N1C(=O)c2cc(Br)n(C(C)C)c2C1c1ccc(Cl)cc1>>COc1ccccc1-c1cc2c(n1C(C)C)C(c1ccc(Cl)cc1C)N(c1cc(Cl)c(=O)n(C)c1)C2=O",
        "output": "869"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.FC(F)(F)c1cccc(CNc2nc(Cl)nc3ccc(C(c4ccc(Cl)cc4)c4ccc(Cl)cc4)cc23)c1.[H-].[N-]=[N+]=NCCCCO.[Na+]>>[N-]=[N+]=NCCCCOc1nc(NCc2cccc(C(F)(F)F)c2)c2cc(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)ccc2n1",
        "output": "37"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=C[C@@H]1CC[C@@H]([C@@H]2CC[C@@H](CO)CC2)CC1.CN(C)c1ccncc1.CS(=O)(=O)Cl.Cl.ClCCl.c1ccncc1>>C=C[C@@H]1CC[C@@H]([C@@H]2CC[C@@H](COS(C)(=O)=O)CC2)CC1",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCC.CO.C[Si](C)(C)C=[N+]=[N-].Cc1ccccc1.N#Cc1ccc(C(=O)O)c(F)c1>>COC(=O)c1ccc(C#N)cc1F",
        "output": "195"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.O=C1CN(C(=O)OCc2ccccc2)CCN1Cc1ccc2nc(Cl)ccc2c1.Oc1ccccc1.[K+].[Na+].[OH-].[OH-]>>O=C1CN(C(=O)OCc2ccccc2)CCN1Cc1ccc2nc(Oc3ccccc3)ccc2c1",
        "output": "516"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.N#Cc1c(F)cc(Br)cc1F.NC1CCC(O)CC1.O>>N#Cc1c(F)cc(Br)cc1NC1CCC(O)CC1",
        "output": "572"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CCOc1ccc(C(=O)O)cc1.O=S(Cl)Cl>>C=CCOc1ccc(C(=O)Cl)cc1",
        "output": "3"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(F)cc1C(=O)c1cnc(NC2CCN(S(=O)(=O)CCCCl)CC2)nc1N.C[C@@H](N)CO>>COc1ccc(F)cc1C(=O)c1cnc(NC2CCN(S(=O)(=O)CCCN[C@H](C)CO)CC2)nc1N",
        "output": "279"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CN(C)CCN.O=C(O)c1ccccc1-c1ccc(CSCCOc2ccccc2)cc1.O=C(n1ccnc1)n1ccnc1>>CN(C)CCNC(=O)c1ccccc1-c1ccc(CSCCOc2ccccc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)CCc1ccncc1.Cl.O.[K+].[OH-]>>O=C(O)CCc1ccncc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1cc(Oc2nc3cc(-c4ccc(-c5cccc(F)c5)cc4)c(Cl)cc3[nH]2)ccc1C.[Na+].[OH-]>>Cc1ccc(Oc2nc3cc(-c4ccc(-c5cccc(F)c5)cc4)c(Cl)cc3[nH]2)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C(=O)CN)c1ccncc1.O=C(O)C(F)(F)F.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CN(CCN)c1ccncc1",
        "output": "112"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCO.COc1cnc(Cl)nc1Cl.Nc1ccc2[nH]ncc2c1>>COc1cnc(Cl)nc1Nc1ccc2[nH]ncc2c1",
        "output": "161"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)Cc1csc2cc(OCc3cc(-c4ccc(Cl)cc4)on3)c(C)cc12.O=P(O)(O)O.[K+].[OH-]>>Cc1cc2c(CC(=O)O)csc2cc1OCc1cc(-c2ccc(Cl)cc2)on1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCC(=O)Cl.COc1cc(OCC2CC2)c(-c2ncnc3c(C(=O)N[C@@H]4CC[C@@H](N)CC4)c(C)[nH]c23)cc1F.Cl>>COCC(=O)N[C@@H]1CC[C@@H](NC(=O)c2c(C)[nH]c3c(-c4cc(F)c(OC)cc4OCC4CC4)ncnc23)CC1",
        "output": "45"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4ccc(C5CCN(C(=O)OC(C)(C)C)CC5)nc4)cnc32)cc1.Cc1ccc(S(=O)(=O)n2cc(-c3cnn(Cc4cccc(F)c4)c3)c3cc(-c4ccc(C5CCNCC5)cc4)cnc32)cc1.Cl.O.[Li+].[OH-]>>CC(C)(C)OC(=O)N1CCC(c2ccc(-c3cnc4[nH]cc(-c5cnn(Cc6cccc(F)c6)c5)c4c3)cn2)CC1",
        "output": "949"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.C[O-].O=C(CN1CCc2ncnc(Cl)c2CC1)N1CCN(C2CCC2)CC1.[Na+]>>COc1ncnc2c1CCN(CC(=O)N1CCN(C3CCC3)CC1)CC2",
        "output": "461"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1NCCc2ccc(Br)cc21.O=C(O)c1cc2ncc(Cl)cn2n1>>CN1c2cc(Br)ccc2CCN1C(=O)c1cc2ncc(Cl)cn2n1",
        "output": "995"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCc1cnc(-c2cnc(Cl)c(Cl)c2C=O)o1.CO.[BH4-].[Na+]>>CCc1cnc(-c2cnc(Cl)c(Cl)c2CO)o1",
        "output": "356"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN.CO.O.O=Cc1cccc2cc[nH]c12.[BH4-].[Na+]>>CNCc1cccc2cc[nH]c12",
        "output": "441"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CN(C)C1CCNC1.COc1nc(Cl)nc(OC)c1[N+](=O)[O-]>>COc1nc(N2CCC(N(C)C)C2)nc(OC)c1[N+](=O)[O-]",
        "output": "36"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C(O)c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1.c1ccc(CCN2CCNCC2)cc1>>O=C(c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1)N1CCN(CCc2ccccc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCC[N+](CCCC)(CCCC)Cc1ccccc1.COCCc1ccc(O)cc1.ClC(Cl)Cl.OCC1CO1.[Cl-]>>COCCc1ccc(OCC(O)CO)cc1",
        "output": "277"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cl.Cl.ClCCl.N[C@H]1CCCN[C@H]1c1ccccc1.O=C([O-])O.O=Cc1cc(C(F)(F)F)ccc1Oc1ccccc1.[Na+].[Na+]>>FC(F)(F)c1ccc(Oc2ccccc2)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1",
        "output": "468"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCCC.COC(=O)Cc1cc2ccc(Cl)cc2c(-c2ccc(S(=O)(=O)NCc3ccc(OC)cc3)cc2)c1C.O.O.[Li+].[OH-]>>COc1ccc(CNS(=O)(=O)c2ccc(-c3c(C)c(CC(=O)O)cc4ccc(Cl)cc34)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)[O-].COc1ccnc(F)c1.OCc1c(F)cccc1F.[K+]>>COc1ccnc(OCc2c(F)cccc2F)c1",
        "output": "541"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.NCC(=O)O.O.O=C(Cl)CCc1ccc(Cl)cc1.[Na+].[OH-]>>O=C(O)CNC(=O)CCc1ccc(Cl)cc1",
        "output": "585"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Nc1ccc(O)cc1Cl.O=C(Cl)CC12CC3CC(CC(C3)C1)C2>>O=C(CC12CC3CC(CC(C3)C1)C2)Nc1ccc(O)cc1Cl",
        "output": "9"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCC.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COC1(OC)CCNCC1F.F[P-](F)(F)(F)(F)F.N#Cc1ccc(C(=O)O)cn1>>COC1(OC)CCN(C(=O)c2ccc(C#N)nc2)CC1F",
        "output": "256"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=O.CO.Cc1cc(CN(C)CC2CCNCC2)cc2c1C(=O)N(Cc1ccc(OC(F)(F)F)cc1)C2.O.O=CO.[BH3-]C#N.[Na+]>>Cc1cc(CN(C)CC2CCN(C)CC2)cc2c1C(=O)N(Cc1ccc(OC(F)(F)F)cc1)C2",
        "output": "217"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN(C)C=O.Cl.ClCCl.Nc1c(F)ccc(O)c1F.O=C(Cl)C(=O)Cl.O=C(O)c1cc(-c2cccc(F)c2)ccc1Cl.O=C([O-])O.[Na+]>>O=C(Nc1c(F)ccc(O)c1F)c1cc(-c2cccc(F)c2)ccc1Cl",
        "output": "50"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1ccc(/C=C\\c2ccc3c(c2)C(C)(C)CCC3(C)C)cc1.O.[K+].[OH-]>>CC1(C)CCC(C)(C)c2cc(/C=C\\c3ccc(C(=O)O)cc3)ccc21",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)CC1(O)CCN(C(=O)OC(C)(C)C)C1.O.[BH4-].[Li+]>>CC(C)(C)OC(=O)N1CCC(O)(CCO)C1",
        "output": "225"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCCOC.O=C(O)c1ccc(O)c(Br)c1.O=S(Cl)Cl>>O=C(Cl)c1ccc(O)c(Br)c1",
        "output": "3"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COCCCCCCCCCCCC#N.[Al+3].[H-].[H-].[H-].[H-].[K+].[Li+].[OH-]>>COCCCCCCCCCCCCN",
        "output": "246"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)C(=O)Nc2cc([N+](=O)[O-])ccc21.CCOC(C)=O.CO.[H][H].[Pd]>>CC1(C)C(=O)Nc2cc(N)ccc21",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)Cc2ccc(O)cc2NC(=O)N1.CS(C)=O.ClCCCCBr.O.[Na+].[OH-]>>CC1(C)Cc2ccc(OCCCCCl)cc2NC(=O)N1",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CNCCCN(C)C.COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCBr>>COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCCCN(C)CCCN(C)C",
        "output": "73"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.C1COCCOCCOCCOCCO1.CC(=O)N1CCN(c2cc(Cl)c([N+](=O)[O-])cc2C)CC1.CO.[Cl-].[H-].[NH4+].[Na+]>>COc1cc(N2CCN(C(C)=O)CC2)c(C)cc1[N+](=O)[O-]",
        "output": "57"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cccc(C2(O)CCCNC2)c1.O=C(Cl)C(c1ccccc1)c1ccccc1>>COc1cccc(C2(O)CCCN(C(=O)C(c3ccccc3)c3ccccc3)C2)c1",
        "output": "125"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CNC.COC(=O)C(OC)c1ccccn1>>COC(C(=O)N(C)C)c1ccccn1",
        "output": "227"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.N#Cc1ccc(F)cc1CBr.O.OCC(F)(F)F.[H-].[Na+]>>N#Cc1ccc(F)cc1COCC(F)(F)F",
        "output": "464"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CON=C(C(C)=O)C(=O)OC(C)(C)C.Cl.ClCCl>>CON=C(C(C)=O)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(=O)c1ccc(OCCOC)cc1.CCO.Cl.NO.c1ccncc1>>CCC(=NO)c1ccc(OCCOC)cc1",
        "output": "212"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.COc1cccc2c(Cl)nc(Cl)nc12.Nc1ccccc1>>COc1cccc2c(Nc3ccccc3)nc(Cl)nc12",
        "output": "161"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)O.CCN1CCOCC1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.N.O>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O",
        "output": "313"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)S(=O)(=O)NCC(C)(F)c1ccc(I)cc1.O.O.O=C(O)c1ccc(B(O)O)cc1.O=C([O-])[O-].[K+].[K+]>>CC(C)S(=O)(=O)NCC(C)(F)c1ccc(-c2ccc(C(=O)O)cc2)cc1",
        "output": "855"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C1(C)Oc2cc(Oc3ccc(C(F)(F)F)cc3Cl)ccc2N(C)C1=O.CO.Cl.[Na+].[OH-]>>CN1C(=O)C(C)(C(=O)O)Oc2cc(Oc3ccc(C(F)(F)F)cc3Cl)ccc21",
        "output": "192"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCn1nc(-c2cccc(C(C)(C)NS(=O)(=O)CC(F)(F)F)c2)cc1Oc1ccc(C(C)O)cc1.ClCCl.O=C([O-])O.O=S([O-])([O-])=S.[Na+].[Na+].[Na+]>>CCn1nc(-c2cccc(C(C)(C)NS(=O)(=O)CC(F)(F)F)c2)cc1Oc1ccc(C(C)=O)cc1",
        "output": "32"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)n1nc(Br)c2ccc(O)cc2c1=O.CN(C)C=O.CSCCCl.O=C([O-])[O-].[K+].[K+]>>CSCCOc1ccc2c(Br)nn(C(C)C)c(=O)c2c1",
        "output": "74"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(C)N1C(=O)N(S(=O)(=O)c2ccccc2)CC1c1cccc(Br)c1.Cc1ccc(Cl)cc1B(O)O.ClCCl.Cl[Pd]Cl.O.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1ccc(Cl)cc1-c1cccc(C2CN(S(=O)(=O)c3ccccc3)C(=O)N2C(C)C)c1",
        "output": "908"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.Fc1ccc(CBr)cc1.O=C([O-])[O-].O=Cc1cc(C(F)(F)F)ccc1O.[K+].[K+]>>O=Cc1cc(C(F)(F)F)ccc1OCc1ccc(F)cc1",
        "output": "127"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(C)(C#N)N=NC(C)(C)C#N.COC(=O)c1c(C)cc(Cl)nc1Cl.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COC(=O)c1c(CBr)cc(Cl)nc1Cl",
        "output": "29"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.O=C(O)c1cc(Br)ccc1O.O=S(=O)(O)O>>CCOC(=O)c1cc(Br)ccc1O",
        "output": "33"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(C)(C)c1ccc(Nc2nc(-c3ccccc3)nc3c2CCN(Cc2ccccc2)C3)cc1.CCOC(C)=O.CO>>CC(C)(C)c1ccc(Nc2nc(-c3ccccc3)nc3c2CCNC3)cc1",
        "output": "84"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(c1ccc2c(c1)sc(=O)n2COCC[Si](C)(C)C)c1ccn(-c2ccc(CO)cn2)n1.ClC(Cl)Cl.[Mn+4].[O-2].[O-2]>>CC(c1ccc2c(c1)sc(=O)n2COCC[Si](C)(C)C)c1ccn(-c2ccc(C=O)cn2)n1",
        "output": "520"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCN(CC)CC.CCOC(C)=O.COC(=O)[C@@H](N)[C@@H](C)O.Cl.ClCCl.O=C(O)c1ccc([N+](=O)[O-])cc1OCc1ccccc1.On1nnc2ccccc21>>COC(=O)[C@@H](NC(=O)c1ccc([N+](=O)[O-])cc1OCc1ccccc1)[C@@H](C)O",
        "output": "652"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)C=O.ClCCCl.O=C(N[C@H](CNC[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)Cc1ccccc1)OCc1cncs1.O=C([O-])O.[Na+].[Na+]>>CC(C)CN(C[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)C[C@H](Cc1ccccc1)NC(=O)OCc1cncs1",
        "output": "484"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COc1cccc(C(F)(F)F)c1C(=O)O.ClCCl.O=C(Cl)C(=O)Cl>>COc1cccc(C(F)(F)F)c1C(=O)Cl",
        "output": "448"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1nnnn1-c1ccc(C(CC2CCCC2)C(=O)O)cc1F.ClCCl.Nc1nccs1.O=C1CCC(=O)N1Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1nnnn1-c1ccc(C(CC2CCCC2)C(=O)Nc2nccs2)cc1F",
        "output": "681"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "B.C1CCOC1.O=C(O)c1cc(O)ccc1Cl>>OCc1cc(O)ccc1Cl",
        "output": "72"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=C1CC[C@@H](C(=O)O)[C@H](c2ccccc2)C1.O=S(=O)(O)O>>CCOC(=O)[C@@H]1CCC(=O)C[C@H]1c1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCI.CN(C)C=O.O.O=C(O)CCCCCCC1CCN(C(=O)OCc2ccccc2)CC1.O=C([O-])O.[Na+]>>CCOC(=O)CCCCCCC1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "196"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cl.Nc1ccccc1.O.O=Cc1ccccc1O>>Oc1ccccc1C=Nc1ccccc1",
        "output": "329"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)c1oc2cccc(OCCCN(Cc3cccnc3)C(=O)OC(C)(C)C)c2c1C.CCOC(C)=O.Cl.O.[Li+].[OH-]>>Cc1c(C(=O)O)oc2cccc(OCCCN(Cc3cccnc3)C(=O)OC(C)(C)C)c12",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)N=NC(=O)OCC.COC(=O)COc1cc(C2CC2)c(O)cc1C.ClCCl.OCCCc1nc(-c2ccc(C(F)(F)F)cc2)cs1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)COc1cc(C2CC2)c(OCCCc2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1C",
        "output": "478"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CC(Nc2nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc(N3CCOCC3)n2)C1.ClCCl.O=C(O)C(F)(F)F>>O=C(Nc1ccncc1)Nc1ccc(-c2nc(NC3CNC3)nc(N3CCOCC3)n2)cc1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCNCC.Cc1c(C(=O)NC(CC(=O)Cl)c2cccc(Br)c2)cnn1-c1ccc(Cl)c(Cl)c1.ClCCCl>>CCN(CC)C(=O)CC(NC(=O)c1cnn(-c2ccc(Cl)c(Cl)c2)c1C)c1cccc(Br)c1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)cc1C)CC.CCOC(=O)Cc1ccc(Cl)nc1.CN(C)C=O.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>CCOC(=O)Cc1ccc(-c2ccc(C(CC)(CC)c3ccc(/C=C/C(O)(CC)CC)c(C)c3)cc2)nc1",
        "output": "955"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc2nc(-c3cccc([N+](=O)[O-])c3)[nH]c(=O)c2cc1OC.CS(=O)(=O)O.CSCC[C@H](N)C(=O)O.O=C([O-])O.[Na+]>>COc1cc2nc(-c3cccc([N+](=O)[O-])c3)[nH]c(=O)c2cc1O",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)c1ccncc1.COc1cnc(C(=O)O)cc1OCC1CC1.Nc1c(Cl)c[n+]([O-])cc1Cl>>COc1cnc(C(=O)Nc2c(Cl)c[n+]([O-])cc2Cl)cc1OCC1CC1",
        "output": "548"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC1(C)OC2OC(C3NC(=O)CC3O)C(O)C2O1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC1(C)OC2OC(C3NCCC3O)C(O)C2O1",
        "output": "112"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cccc(N)n2)CC1.CN(C)C=O.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1CCN(c2ccc(Br)c(N)n2)CC1",
        "output": "518"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.CC(C)(C)OC(=O)NCCN.ClCCl>>CC(=O)NCCNC(=O)OC(C)(C)C",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)c1ccc(S(N)(=O)=O)cc1.Cc1nn(-c2ccc(CCNC(=O)Oc3ccccc3)cc2)c(C)c1-c1ccccc1>>Cc1nn(-c2ccc(CCNC(=O)NS(=O)(=O)c3ccc(S(C)(=O)=O)cc3)cc2)c(C)c1-c1ccccc1",
        "output": "690"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.O=C(OCc1ccccc1)c1ccc2c(ccn2C(=O)c2ccccc2)c1.[H][H].[Pd]>>O=C(O)c1ccc2c(ccn2C(=O)c2ccccc2)c1",
        "output": "290"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1ccc(Br)cc1.CN1CCCC1=O.N#C[Cu]>>CCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1ccc(C#N)cc1",
        "output": "531"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.COC(=O)c1nc(Cl)c(F)c(N)c1Cl.COc1nc(C(F)(F)F)ccc1B1OC(C)(C)C(C)(C)O1.ClCCl.Cl[Pd]Cl.O.[F-].[K+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1nc(-c2ccc(C(F)(F)F)nc2OC)c(F)c(N)c1Cl",
        "output": "968"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].Cc1ccccc1.Cn1c(CN2CCC(C(C)(C)O)CC2)nc2c(N3CCOCC3)nc(Cl)nc21.Nc1ccccc1N.[Na+].[Pd+2]>>Cn1c(CN2CCC(C(C)(C)O)CC2)nc2c(N3CCOCC3)nc(Nc3ccccc3N)nc21",
        "output": "592"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CS(C)=O.C[C@H]1CNCCN1.Cc1c(-c2ccccc2)c(Cl)n2c(nc3ccccc32)c1C#N.O>>Cc1c(-c2ccccc2)c(N2CCN[C@@H](C)C2)n2c(nc3ccccc32)c1C#N",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CSc1onc(C)c1-c1cccc2ccccc12.CO.[Na+].[OH-]>>Cc1noc(SCC(=O)O)c1-c1cccc2ccccc12",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=O.CCOC(=O)c1nc(-c2ccc(O)cc2)nc(N2CCOCC2)c1OCC.Cc1ccccc1>>CCNC(=O)Oc1ccc(-c2nc(C(=O)OCC)c(OCC)c(N3CCOCC3)n2)cc1",
        "output": "104"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN1CCC(CN)(c2ccc(Cl)c(Cl)c2)CC1.CCOCC.N#Cc1cc(C(=O)Cl)c2ccccc2c1>>CCN1CCC(CNC(=O)c2cc(C#N)cc3ccccc23)(c2ccc(Cl)c(Cl)c2)CC1",
        "output": "271"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COc1ccc(C2=NN(C3CCN(C(=O)[C@H](C)NC(=O)OC(C)(C)C)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.Cl.[Na+].[OH-]>>COc1ccc(C2=NN(C3CCN(C(=O)[C@H](C)N)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC",
        "output": "431"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Cc1[nH]cnc1CO>>Cc1[nH]cnc1CO[Si](C)(C)C(C)(C)C",
        "output": "193"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccc(-c2nc3ccc(Br)cc3o2)cc1.CC(C)(C)OC(=O)N1CCNCC1>>CC(C)(C)OC(=O)N1CCN(Cc2ccc(-c3nc4ccc(Br)cc4o3)cc2)CC1",
        "output": "248"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.OCCCc1cccnc1.Oc1cccnc1Sc1cccc(Br)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Brc1cccc(Sc2ncccc2OCCCc2cccnc2)c1",
        "output": "547"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CN(C)CCCN.CN(C)CCCNC(=O)c1cccc(-c2ccc(CSCCOc3ccccc3)cc2)c1.O=C(O)c1ccccc1-c1ccccc1CSCCOc1ccccc1>>CN(C)CCCNC(=O)c1ccccc1-c1ccccc1CSCCOc1ccccc1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CSC.N#CCC(O)c1cccc(Br)c1>>NCCC(O)c1cccc(Br)c1",
        "output": "246"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1ccc(-c2nc(Cl)c3cc(C(F)(F)F)sc3n2)cc1.NCCc1ccc2c(c1)OCO2>>COC(=O)c1ccc(-c2nc(NCCc3ccc4c(c3)OCO4)c3cc(C(F)(F)F)sc3n2)cc1",
        "output": "723"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCCCCC(=O)Cl.ClCCl.O=C(O)c1ccc(O)c(Cl)c1.c1ccncc1>>CCCCCCCCC(=O)Oc1ccc(C(=O)O)cc1Cl",
        "output": "111"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(=O)c1cnn(-c2nc3cc(I)ccc3c(=O)[nH]2)c1.COCCOCCl>>CCOC(=O)c1cnn(-c2nc3cc(I)ccc3c(=O)n2COCCOC)c1",
        "output": "712"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)C[C@@H](c1ccc(OCc2ccc(-c3ccc(C(F)(F)F)cc3)s2)cc1)c1ccon1.[Li+].[OH-]>>O=C(O)C[C@@H](c1ccc(OCc2ccc(-c3ccc(C(F)(F)F)cc3)s2)cc1)c1ccon1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.S=C(NCCc1ccc(Cl)cc1)Nc1ccc(Br)cn1>>COc1ccc(CCNC(=S)Nc2ccc(Br)cn2)cc1",
        "output": "57"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COC(=O)C1=Cc2cc(OCc3cccc(OC)c3)ccc2S(=O)(=O)CC1.Cl.O=C([O-])[O-].[K+].[K+]>>COc1cccc(COc2ccc3c(c2)C=C(C(=O)O)CCS3(=O)=O)c1",
        "output": "58"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.Cc1cc(C(=O)Cl)c(C)n1-c1ccc(F)cc1C(F)(F)F.Nc1ccc(S(N)(=O)=O)cc1>>Cc1cc(C(=O)Nc2ccc(S(N)(=O)=O)cc2)c(C)n1-c1ccc(F)cc1C(F)(F)F",
        "output": "642"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cl.N[C@H]1CC[C@H](O)CC1.O=C(Cl)OCc1ccccc1>>O=C(N[C@@H]1CC[C@@H](O)CC1)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Brc1ccc2sc3ccccc3c2c1.CCOCC.CN(C)C=O.[Cl-].[Li]CCCC.[NH4+]>>O=Cc1ccc2sc3ccccc3c2c1",
        "output": "638"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.CCOC(=O)CCc1c(C(=O)O)n2c3c(cccc13)OCC2.CI.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CCc1c(C(=O)OC)n2c3c(cccc13)OCC2",
        "output": "415"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCCCCCCBr.CCCCCC.CCOC(C)=O.CN(C)C=O.COC(=O)c1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(OCCCCCCBr)cc1",
        "output": "385"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc([C@@H](C(=O)OC(C)(C)C)C2CCCC2)cc1.ClC(Cl)Cl.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)[C@H](c1ccc(CBr)cc1)C1CCCC1",
        "output": "29"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.COc1ccc(C23CCC(CC2)N2CCS(=O)(=O)N=C23)cc1.ClCCl.O=C([O-])O.[Na+]>>O=S1(=O)CCN2C(=N1)C1(c3ccc(O)cc3)CCC2CC1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.N#Cc1cccc(OCCN)c1.O=S(=O)(Cl)c1ccc2ccccc2c1>>N#Cc1cccc(OCCNS(=O)(=O)c2ccc3ccccc3c2)c1",
        "output": "43"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.C[C@H](N)c1cc2ccc(F)cc2nc1CN1CCN(C(=O)OC(C)(C)C)CC1.N#Cc1c(N)ncnc1Cl>>C[C@H](Nc1ncnc(N)c1C#N)c1cc2ccc(F)cc2nc1CN1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "110"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=C(Cc1cccc([N+](=O)[O-])c1)N1CCCC1.O=C[O-].[NH4+].[Pd]>>Nc1cccc(CC(=O)N2CCCC2)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.N#Cc1cc(F)c(CC(=O)O)cc1F.O=S(Cl)Cl>>COC(=O)Cc1cc(F)c(C#N)cc1F",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COc1ccc(C)cc1C(=O)O.Cl.ClCCCl.ClCCl.N[C@H]1CCC[C@@H]1Nc1cnc(C(F)(F)F)cn1.N[C@H]1CCC[C@@H]1Nc1cnc(C(F)(F)F)cn1.On1nnc2cccnc21>>COc1ccc(C)cc1C(=O)N[C@H]1CCC[C@@H]1Nc1cnc(C(F)(F)F)cn1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C(=O)O)C(F)(F)F.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1ccc(NC(=O)c2cc(CN)ccc2Cl)cc1C(=O)Nc1ccc(Br)cc1.F[B-](F)(F)F>>COc1ccc(NC(=O)c2cc(CNC(=O)C(C)(C)C(F)(F)F)ccc2Cl)cc1C(=O)Nc1ccc(Br)cc1",
        "output": "599"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.COc1cc(F)cc(O)c1[N+](=O)[O-].CS(C)=O.O>>COc1cc(N2CCOCC2)cc(O)c1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)c1cc([N+](=O)[O-])c(N2CCCCC2)c(S(C)(=O)=O)c1.[C].[Pd]>>COC(=O)c1cc(N)c(N2CCCCC2)c(S(C)(=O)=O)c1",
        "output": "481"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CC[C@H](NCC2CCOC2)C1.CC(Cl)Cl.O=Cc1ccccc1C(F)(F)F.[Na+]>>CC(C)(C)OC(=O)N1CC[C@H](N(Cc2ccccc2C(F)(F)F)CC2CCOC2)C1",
        "output": "567"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CSC.O=C(Cc1ccccc1)N(C[C@H]1CNC[C@@H]1Cc1ccccc1)c1ccccc1>>c1ccc(CCN(C[C@H]2CNC[C@@H]2Cc2ccccc2)c2ccccc2)cc1",
        "output": "112"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C(C)N1CCC(C(F)F)c2ccccc21.CO.O=C([O-])O.[Na+].[Na+].[OH-]>>CC(C(=O)O)N1CCC(C(F)F)c2ccccc21",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCO.CCOC(C)=O.Cn1c(Cl)ncc(Br)c1=O.NCc1ccccc1.O=C([O-])O.[Na+]>>Cn1c(NCc2ccccc2)ncc(Br)c1=O",
        "output": "364"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=CC(c1ccccc1)c1ccccc1Br.[BH4-].[Na+]>>OCC(c1ccccc1)c1ccccc1Br",
        "output": "223"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.Cc1oc(-c2ccc(Br)cc2)nc1CCN1CCCCC1C.O=C([O-])[O-].OB(O)c1ccncc1.[Na+].[Na+]>>Cc1oc(-c2ccc(-c3ccncc3)cc2)nc1CCN1CCCCC1C",
        "output": "904"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CSc1c(CC(N)=O)ccc2c3ccccc3n(Cc3ccccc3)c12.Cc1ccc(S(=O)(=O)Cl)cc1.O.c1ccncc1>>CSc1c(CC#N)ccc2c3ccccc3n(Cc3ccccc3)c12",
        "output": "172"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCC(=O)N1C[C@@H]2C[C@@H](c3ccc(NS(=O)(=O)c4ccc(C(C)C)cc4)cc3)[C@@H]2C1.Cl>>CCCN1C[C@@H]2C[C@@H](c3ccc(NS(=O)(=O)c4ccc(C(C)C)cc4)cc3)[C@@H]2C1",
        "output": "112"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.Cn1c(C(F)(F)F)cc(=O)n(-c2cc(Oc3ccc(OCc4ccccc4)cc3)c([N+](=O)[O-])cc2F)c1=O.O.[Fe]>>Cn1c(C(F)(F)F)cc(=O)n(-c2cc(Oc3ccc(OCc4ccccc4)cc3)c(N)cc2F)c1=O",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)[C@H](C)Oc1cc(Oc2c(C=C(C)C)c(C)nn2C)c(Cl)cc1Cl.Cl.O.O.[Li+].[OH-]>>CC(C)=Cc1c(C)nn(C)c1Oc1cc(O[C@@H](C)C(=O)O)c(Cl)cc1Cl",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)OCc1ccc(CC(=O)O)s1.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.COc1ccc([C@@H](O)Cc2c(Cl)c[n+]([O-])cc2Cl)cc1OC.Cl.ClCCl>>COc1ccc([C@H](Cc2c(Cl)c[n+]([O-])cc2Cl)OC(=O)Cc2ccc(CO[Si](C)(C)C(C)(C)C)s2)cc1OC",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.Cc1ccccc1.O=C=Nc1ccccc1F>>COc1cc2ncnc(Oc3ccc(NC(=O)Nc4ccccc4F)cc3)c2cc1OC",
        "output": "912"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)C.CCN(CC)CC.COC(=O)c1cc(C(C)(C)C)cc(NC(=O)Oc2ccccc2)c1OC.Nc1ccc(Oc2ccnc(Nc3ccccc3)c2)c(F)c1F>>COC(=O)c1cc(C(C)(C)C)cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)c3)c(F)c2F)c1OC",
        "output": "965"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CON.O.O=Cc1ccc2c(c1)c1c(n2Cc2cccc(F)c2)CCC(NC(=O)C2CC2)C1.[Na+].[OH-]>>CON=Cc1ccc2c(c1)c1c(n2Cc2cccc(F)c2)CCC(NC(=O)C2CC2)C1",
        "output": "30"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(N)C(=O)O.CCCC(=O)Cl.CCCCOC(C)=O.Cl.[Na+].[OH-]>>CCCC(=O)NC(C)C(=O)O",
        "output": "585"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.ClCCl.Nc1cccc2cccnc12.O=C(Cl)c1ccc(Br)cc1>>O=C(Nc1cccc2cccnc12)c1ccc(Br)cc1",
        "output": "501"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(OC(c2sc(-c3ccccc3)cc2C)C2CCCCC2)cc1.Cl.O.[Na+].[OH-]>>Cc1cc(-c2ccccc2)sc1C(Oc1ccc(C(=O)O)cc1)C1CCCCC1",
        "output": "222"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)(C(C(=O)O)c2ccc(F)cc2)CC1.CCN(CC)CC.CCN=C=NCCC(NC)NC.CCOC(C)=O.CN(C)C=O.Cl.Cl.Cl.O.On1nnc2ccccc21.c1ccc2c(CCCCN3CCNCC3)cccc2c1>>CC(C)(C)OC(=O)N1CCC(O)(C(C(=O)N2CCN(CCCCc3cccc4ccccc34)CC2)c2ccc(F)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)CC(C)(C)C.COc1cc(C(=O)O)ccc1[N+](=O)[O-].O=S(Cl)Cl>>COc1cc(C(=O)Cl)ccc1[N+](=O)[O-]",
        "output": "3"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.NCCCO.O.O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)C1c2ccccc2CSc2ccccc21)Oc1ccccc1.O=C([O-])[O-].[K+].[K+]>>O=C(NCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)C1c2ccccc2CSc2ccccc21",
        "output": "488"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CBr.CN(C)C=O.Cl.O.O=C(NCC1CCNCC1)c1n[nH]c2ccc(Br)cc12.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CN1CCC(CNC(=O)c2n[nH]c3ccc(Br)cc23)CC1",
        "output": "467"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.O=C1CCC(=O)N1Br.c1ccc2cnccc2c1>>Brc1cc2ccccc2cn1",
        "output": "779"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.Cc1ccccc1.Cl.N#Cc1nccnc1Cl.O.O.O=C1CCNCC1>>N#Cc1nccnc1N1CCC(=O)CC1",
        "output": "505"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.Nc1cc(Oc2ncccn2)c(Cl)cc1F.S=C(Cl)Cl>>Fc1cc(Cl)c(Oc2ncccn2)cc1N=C=S",
        "output": "114"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=O.CCCCCC(=O)Cl.Nc1ccc(O)c(C(=O)O)c1.O.O=C([O-])[O-].[K+].[K+]>>CCCCCC(=O)Nc1ccc(O)c(C(=O)O)c1",
        "output": "9"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)Cn1nc(-c2ccccc2O)nc1-c1ccccc1O.NCC(O)CO>>O=C(Cn1nc(-c2ccccc2O)nc1-c1ccccc1O)NCC(O)CO",
        "output": "64"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)Cl.ClCCl.O=C([O-])O.[N-]=[N+]=N[C@@H]1COC[C@H]1O.[Na+].c1ccncc1>>CS(=O)(=O)O[C@@H]1COC[C@H]1N=[N+]=[N-]",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CCCCCOc1ccc(C(CC)(CC)c2ccc(C#CC3(O)CCCCC3)c(C)c2)cc1C.CO.[Cl-].[K+].[NH4+].[OH-]>>CCC(CC)(c1ccc(C#CC2(O)CCCCC2)c(C)c1)c1ccc(OCCCCCC(=O)O)c(C)c1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cn1ccc(S(=O)(=O)N(Cc2ccccc2)c2ccc3c(c2)CCNC3)n1.F[P-](F)(F)(F)(F)F>>CC(=O)N1CCc2cc(N(Cc3ccccc3)S(=O)(=O)c3ccn(C)n3)ccc2C1",
        "output": "633"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCc1c(OCCCOc2ccc(C(=O)C(=O)OCC)cc2)ccc(C(C)=O)c1OC.CO.[Na+].[OH-]>>CCCc1c(OCCCOc2ccc(C(=O)C(=O)O)cc2)ccc(C(C)=O)c1OC",
        "output": "472"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CN(CCO[Si](C)(C)C(C)(C)C)C1CCN(c2ccc(Nc3ncc4c(n3)N(S(=O)(=O)c3cccc5cccnc35)CC4(C)C)cc2)CC1.[F-]>>CN(CCO)C1CCN(c2ccc(Nc3ncc4c(n3)N(S(=O)(=O)c3cccc5cccnc35)CC4(C)C)cc2)CC1",
        "output": "708"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccc(B(O)O)cc1.Fc1cccc(-c2nc3cnn(Cc4ccc(Cl)nn4)cc-3n2)c1F>>Cc1ccc(-c2ccc(Cn3cc4nc(-c5cccc(F)c5F)nc-4cn3)nn2)cc1",
        "output": "866"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)[O-].CO.Cl.NO.O.O=C1CC2CCC(C1)N2Cc1ccccc1.[Na+].[Na+].[OH-]>>ON=C1CC2CCC(C1)N2Cc1ccccc1",
        "output": "86"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCC(N2CCC3(CCNC3)CC2)CC1.C[Si](C)(C)CCOCn1ccnc1CC(COc1ccc(C(=O)O)cc1)Cc1nccn1COCC[Si](C)(C)C>>C[Si](C)(C)CCOCn1ccnc1CC(COc1ccc(C(=O)N2CCC3(CCN(C4CCCCC4)CC3)C2)cc1)Cc1nccn1COCC[Si](C)(C)C",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=S)N1CCCC(=O)O.ClCCCl.ClCCl.NCCOCCOC(=O)CC12CC3CC(CC(C3)C1)C2.On1nnc2ccccc21>>CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=S)N1CCCC(=O)NCCOCCOC(=O)CC12CC3CC(CC(C3)C1)C2",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CO.Cc1c(CN(CCc2cc3cccc(F)c3n2C)C(=O)C(F)(F)F)ncn1S(=O)(=O)N(C)C.O=C([O-])[O-].[K+].[K+]>>Cc1c(CNCCc2cc3cccc(F)c3n2C)ncn1S(=O)(=O)N(C)C",
        "output": "703"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.CC(=O)[O-].CCOC(C)=O.Cc1c(C)c2c(c(C)c1O)CCC(C)(CCCC(C)(Cl)CCCC(C)(Cl)CCCC(C)(C)Cl)O2.Cl.O.[Cl-].[Cl-].[Na+].[Zn+2]>>CC(=O)Oc1c(C)c(C)c2c(c1C)CCC(C)(CCCC(C)(Cl)CCCC(C)(Cl)CCCC(C)(C)Cl)O2",
        "output": "46"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrBr.ClC(Cl)Cl.O=C(O)c1cccc2nc3ccc4c(O)cccc4c3nc12>>O=C(O)c1cccc2nc3ccc4c(O)c(Br)ccc4c3nc12",
        "output": "98"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCN=C=NCCCN(C)C.Cl.NC(Cc1cccc(C(F)(F)F)c1)C(O)c1ccc(F)cc1.O.O=C(O)CCCc1ccccc1.On1nnc2ccccc21>>O=C(CCCc1ccccc1)NC(Cc1cccc(C(F)(F)F)c1)C(O)c1ccc(F)cc1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)c1cccc(Cn2ccc3cc(OCc4c(CSc5nccs5)noc4C(C)C)ccc32)c1.Cc1cccc(C)c1OCc1noc(C(C)C)c1COc1ccc2c(ccn2Cc2cccc(C(=O)O)c2)c1.Cl.[Na+].[OH-]>>CC(C)c1onc(CSc2nccs2)c1COc1ccc2c(ccn2Cc2cccc(C(=O)O)c2)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1cc(S(C)(=O)=O)ccc1-c1cc(Br)ccc1F.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1cc(S(C)(=O)=O)ccc1-c1cc(B2OC(C)(C)C(C)(C)O2)ccc1F",
        "output": "942"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc2c(ccn2Cc2ccccc2)c1.C1COCCO1.ClCCl.O.O=C([O-])[O-].OB(O)c1ccc(OC(F)(F)F)cc1.[K+].[K+]>>FC(F)(F)Oc1ccc(-c2ccc3c(ccn3Cc3ccccc3)c2)cc1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.COC(=O)C1CCN(C(=O)c2ccc3c(c2)nc(C(C)(C)C)n3CC2CCC(F)(F)CC2)CC1.O=S(=O)([O-])O.[K+].[Li+].[OH-]>>CC(C)(C)c1nc2cc(C(=O)N3CCC(C(=O)O)CC3)ccc2n1CC1CCC(F)(F)CC1",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN1CCCC1=O.COC(=O)[C@H]1CCC[C@@H](N)C1.Cl.O=S(=O)(c1ccccc1)n1cc(-c2nc(Cl)ncc2Cl)c2ccccc21>>COC(=O)[C@H]1CCC[C@@H](Nc2ncc(Cl)c(-c3cn(S(=O)(=O)c4ccccc4)c4ccccc34)n2)C1",
        "output": "544"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O.O=C([O-])[O-].O=C(c1ccc(Br)cc1)C1CCN(C(=O)C(F)(F)F)CC1.[K+].[K+]>>O=C(c1ccc(Br)cc1)C1CCNCC1",
        "output": "703"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCN1CCCC(c2ccccc2)C1.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>CCCN1CCCC(c2ccc([N+](=O)[O-])cc2)C1",
        "output": "103"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCC1CC1.C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.O=S(=O)([O-])O.O=S(=O)(c1cccc(Br)c1)N1CCC2=Cc3c(cnn3-c3ccc(F)cc3)C[C@]2(CO)C1.[I-].[Na+].[OH-]>>O=S(=O)(c1cccc(Br)c1)N1CCC2=Cc3c(cnn3-c3ccc(F)cc3)C[C@]2(COCC2CC2)C1",
        "output": "95"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCC(O)(C#Cc1ccc(C(CC)(CC)c2ccc(-c3ccc(CC(=O)OC)cc3)c(C)c2)cc1C)CC.CO.[Cl-].[NH4+].[Na+].[OH-]>>CCC(O)(C#Cc1ccc(C(CC)(CC)c2ccc(-c3ccc(CC(=O)O)cc3)c(C)c2)cc1C)CC",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COc1cc(-c2cc(Cl)ccc2F)ncn1.FC(F)(F)c1cn[nH]c1.[H-].[Na+]>>COc1cc(-c2cc(Cl)ccc2-n2cc(C(F)(F)F)cn2)ncn1",
        "output": "751"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(=O)c1cc(C)ccc1-n1nccn1)[C@@H](C)CO.ClC(Cl)Cl.O=S(Cl)Cl>>CCN(C(=O)c1cc(C)ccc1-n1nccn1)[C@@H](C)CCl",
        "output": "96"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CO1.CCC(C)=O.O=C([O-])[O-].O=C(c1ccc(Cn2nccc2-c2ccc(O)cc2)cc1)N1CCCC1.[K+].[K+]>>O=C(c1ccc(Cn2nccc2-c2ccc(OCC3CO3)cc2)cc1)N1CCCC1",
        "output": "18"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Brc1cccc(Br)c1.C1CCOC1.CCCCCC.COc1ccc(C=O)cc1.[Li]CCCC>>COc1ccc(C(O)c2cccc(Br)c2)cc1",
        "output": "379"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)=O.CCOCC.COCCCS(=O)(=O)c1ccc(-c2ccc(CC(=O)O)cc2)cc1.FB(F)F.[BH4-].[Na+].[Na+].[OH-]>>COCCCS(=O)(=O)c1ccc(-c2ccc(CCO)cc2)cc1",
        "output": "231"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.Cl.Cl[Sn]Cl.O=C(Nc1nccs1)c1nc(-c2ccc([N+](=O)[O-])cc2)[nH]c1-c1ccc(Cl)cc1>>Nc1ccc(-c2nc(C(=O)Nc3nccs3)c(-c3ccc(Cl)cc3)[nH]2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CO.O.O=C(O)c1ccc(Nc2cc(OC3CC3)ncn2)cc1.O=S(Cl)Cl>>COC(=O)c1ccc(Nc2cc(OC3CC3)ncn2)cc1",
        "output": "195"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1ccc(OCCN2CCCC2)cc1.C1COCCO1.CC(=O)N(C)C.CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Cc1cc(-c2ccc3c(c2)OCCO3)n2nc(N)nc2c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1cc(-c2ccc3c(c2)OCCO3)n2nc(Nc3ccc(OCCN4CCCC4)cc3)nc2c1",
        "output": "970"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COc1cc(CC(=O)N2CCCC2CN[C@@H]2CC[C@H](C(=O)OCc3ccccc3)CC2)ccc1NC(=O)Nc1ccccc1C.[Na+].[OH-]>>COc1cc(CC(=O)N2CCCC2CN[C@@H]2CC[C@H](C(=O)O)CC2)ccc1NC(=O)Nc1ccccc1C",
        "output": "186"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.ClCCl.O=S(=O)(Cl)c1ccccc1.c1ccc2c(c1)CCN2>>O=S(=O)(c1ccccc1)N1CCc2ccccc21",
        "output": "791"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Br.Nc1cccc2cnccc12.O.O.O=N[O-].[Na+].[Na+].[OH-]>>Brc1cccc2cnccc12",
        "output": "373"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CCN(CC)CC.C[C@H](N)Cn1ccc(-c2cc(F)c(C#N)c(Cl)c2)n1.ClCCl.O=C(O)c1cc(CBr)on1>>C[C@@H](Cn1ccc(-c2cc(F)c(C#N)c(Cl)c2)n1)NC(=O)c1cc(CBr)on1",
        "output": "696"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.O=C(Cl)c1ccccc1.O=C(Nc1cc(Cl)c(O)cc1O)c1ccccc1>>O=C(Nc1cc(Cl)c(OC(=O)c2ccccc2)cc1O)c1ccccc1",
        "output": "482"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])cc2CO)CC1.CCO.O=C[O-].[NH4+].[Pd]>>CC(C)(C)OC(=O)N1CCN(c2ccc(N)cc2CO)CC1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)CC(=O)c2c(C(F)(F)F)n[nH]c2C1.CN(C)C=O.N#Cc1ccc(F)cc1Br.[H-].[Na+]>>CC1(C)CC(=O)c2c(C(F)(F)F)nn(-c3ccc(C#N)c(Br)c3)c2C1",
        "output": "751"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cccc(OC)c1C(=O)Cl.NCCSCc1cccc(Cl)c1>>COc1cccc(OC)c1C(=O)NCCSCc1cccc(Cl)c1",
        "output": "271"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1CCNCC1.Cc1ccccc1.O=C([O-])[O-].O=[N+]([O-])c1ccc(Br)nc1Br.[K+].[K+]>>CC1CCN(c2nc(Br)ccc2[N+](=O)[O-])CC1",
        "output": "647"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.NC1CCCCC1.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)c([N+](=O)[O-])c1.[K+].[K+]>>O=[N+]([O-])c1ccc(NC2CCCCC2)c([N+](=O)[O-])c1",
        "output": "304"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClC(Cl)Cl.Nc1cc(S)c(Cl)cc1F.S=C(Cl)Cl>>Fc1cc(Cl)c(S)cc1N=C=S",
        "output": "114"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=C(C)C.ClCCl.O=C(O)C1CC2=C(CN1)N=CCN2C(=O)OCc1ccccc1.O=S(=O)(O)O>>CC(C)(C)OC(=O)C1CC2=C(CN1)N=CCN2C(=O)OCc1ccccc1",
        "output": "511"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.COc1cc(Cl)c2c(c1)cc(B(O)O)n2C(=O)OC(C)(C)C.O=[N+]([O-])O.Oc1cccc(Cl)c1>>O=[N+]([O-])c1ccc(O)cc1Cl",
        "output": "21"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(C)CC(=O)c2ccccc21.O=S(=O)(O)O.O=[N+]([O-])O>>CC1(C)CC(=O)c2cc([N+](=O)[O-])ccc21",
        "output": "21"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCS(=O)c1ccc(B(O)O)cc1.COC(=O)c1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2/C=C/c2ccc(Br)cc2)cc1>>CCS(=O)c1ccc(-c2ccc(/C=C/c3nc(-c4ccc(Cl)cc4Cl)cn3Cc3ccc(C(=O)OC)cc3)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1ccc(Br)cc1S(=O)(=O)NCCO.Cl[Pd]Cl.[K+]>>COc1ccc(B2OC(C)(C)C(C)(C)O2)cc1S(=O)(=O)NCCO",
        "output": "942"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCSc1nc(Cl)cc(C)c1C(=O)NCc1cccc(F)c1.CN1CCCC1=O.C[Si](C)(C)Cl.C[Si](C)(C)N[Si](C)(C)C.Cl.O=C([O-])O.OC[C@H]1COCCN1.[Na+]>>CCSc1nc(N2CCOC[C@@H]2CO)cc(C)c1C(=O)NCc1cccc(F)c1",
        "output": "220"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(CC(=O)O)cc(OC)c1.Nn1nc(-c2ccc(Cl)cc2)c2ccccc2c1=O>>COc1cc(CC(=O)Nn2nc(-c3ccc(Cl)cc3)c3ccccc3c2=O)cc(OC)c1",
        "output": "459"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrBr.CC(=O)c1ccc(Oc2ccc(Cl)cc2)cc1C.ClC(Cl)Cl.O=C([O-])O.[Na+]>>Cc1cc(Oc2ccc(Cl)cc2)ccc1C(=O)CBr",
        "output": "173"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CCO.O.O=[N+]([O-])c1ccc2c(c1)C=CC(NCc1ccccc1)CC2.[Cl-].[Fe].[NH4+]>>Nc1ccc2c(c1)C=CC(NCc1ccccc1)CC2",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.N#Cc1cc([N+](=O)[O-])ccc1Oc1cc(N)c(F)cc1Cl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>N#Cc1cc([N+](=O)[O-])ccc1Oc1cc(NC(=O)C(F)(F)F)c(F)cc1Cl",
        "output": "106"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(=O)(=O)Cl.NC1CCCC(Nc2cc(I)cc(Cl)n2)C1.c1ccncc1>>CS(=O)(=O)NC1CCCC(Nc2cc(I)cc(Cl)n2)C1",
        "output": "493"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C(NCc1ccc(F)cc1)C1(CCCCBr)c2ccccc2-c2ccccc21.c1ccc2sc(N3CCNCC3)nc2c1>>O=C(NCc1ccc(F)cc1)C1(CCCCN2CCN(c3nc4ccccc4s3)CC2)c2ccccc2-c2ccccc21",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1ccc(C(=O)CN(C)Cc2ccc(Cl)cc2Cl)cc1.CO.[BH4-].[Na+]>>CC(=O)Nc1ccc(C(O)CN(C)Cc2ccc(Cl)cc2Cl)cc1",
        "output": "24"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "NCCO[N+](=O)[O-].O=C1NC(C(=O)O)C(c2ccc(Cl)cc2)S1.O=[N+]([O-])O>>O=C1NC(C(=O)NCCO[N+](=O)[O-])C(c2ccc(Cl)cc2)S1",
        "output": "216"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Cc1cc(B2OC(C)(C)C(C)(C)O2)cc(C(=O)O)c1.ClC(Cl)Cl.O=S(Cl)Cl>>Cc1cc(B2OC(C)(C)C(C)(C)O2)cc(C(=O)Cl)c1",
        "output": "3"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "B.C1CCOC1.C1CCOC1.Cl.O=C(CC(c1ccccc1)c1ccccc1)NCc1ccccc1.[Na+].[OH-]>>c1ccc(CNCCC(c2ccccc2)c2ccccc2)cc1",
        "output": "533"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCOC(C)=O.CN(C)C=O.Cc1ccc(S[C@@H]2O[C@H](CO)[C@@H](O)[C@H](OC(=O)c3ccccc3)[C@H]2N2C(=O)c3ccccc3C2=O)cc1.c1c[nH]cn1>>Cc1ccc(S[C@@H]2O[C@H](CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)[C@@H](O)[C@H](OC(=O)c3ccccc3)[C@H]2N2C(=O)c3ccccc3C2=O)cc1",
        "output": "602"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCn1c(Nc2nc3ccc(Cl)cc3s2)nc2cc(C(=O)O)ccc21.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COCCN.F[P-](F)(F)(F)(F)F>>CCn1c(Nc2nc3ccc(Cl)cc3s2)nc2cc(C(=O)NCCOC)ccc21",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CNC(CC(=O)O)c1cccc(O)c1.O=C([O-])O.O=S(=O)(O)O.[Na+]>>CCOC(=O)CC(NC)c1cccc(O)c1",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Cc1cc(O)ncc1Br.O=C1CCC(=O)N1Cl>>Cc1c(Br)cnc(O)c1Cl",
        "output": "743"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)CBr.O=C([O-])[O-].OCCc1ccc(O)cc1.[K+].[K+]>>COC(=O)COc1ccc(CCO)cc1",
        "output": "557"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COc1ccc(-c2c(C)cc3cc(OC)ccc3c2O)cc1.O=Cc1ccc(F)cc1.[H-].[Na+]>>COc1ccc(-c2c(C)cc3cc(OC)ccc3c2Oc2ccc(C=O)cc2)cc1",
        "output": "564"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrC(Br)(Br)Br.Cc1cccc2nc(SCc3ccc(C(=O)N4CCC(CO)CC4)cc3)n(C)c(=O)c12.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cccc2nc(SCc3ccc(C(=O)N4CCC(CBr)CC4)cc3)n(C)c(=O)c12",
        "output": "378"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](OCCCCO)(c1ccccc1)c1ccccc1.CCN(CC)CC.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl>>CC(C)(C)[Si](OCCCC=O)(c1ccccc1)c1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccccc1.O=C(Cl)C1CCCC1.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(C(=O)C2CCCC2)cc1",
        "output": "31"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(Cc2c[nH]c3ccc(F)cc23)CC1.O=S(=O)(Cl)c1ccccc1.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCC(Cc2cn(S(=O)(=O)c3ccccc3)c3ccc(F)cc23)CC1",
        "output": "648"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C(=O)O)c1ccc(Cl)c(C(F)(F)F)c1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@H](C(N)=O)n1ccc2c(N)cccc2c1=O.F[P-](F)(F)(F)(F)F>>CC(C(=O)Nc1cccc2c(=O)n([C@H](C)C(N)=O)ccc12)c1ccc(Cl)c(C(F)(F)F)c1",
        "output": "365"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc(F)ccc1C(=O)Cl.Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1.O=C1CC(=O)N(CCNC(=O)c2ccccc2I)c2ccc3ccccc3c2N1>>COc1cc(F)ccc1C(=O)Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1",
        "output": "11"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCNCC2)c1.O=Cc1ccc2cc[nH]c2c1>>CC(C)C(=O)Nc1cccc(C2CCN(Cc3ccc4cc[nH]c4c3)CC2)c1",
        "output": "567"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(N)CCc1ccc(CCCN2C(=O)c3ccccc3C2=O)nc1.CCO.COC(C)(C)C.NN>>CC(N)CCc1ccc(CCCN)nc1",
        "output": "242"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CO.COc1ccc(-c2cccc3c2CN(CCCCCC(=O)NOCc2ccccc2)C3=O)c(OC)c1.[H][H].[Pd]>>COc1ccc(-c2cccc3c2CN(CCCCCC(=O)NO)C3=O)c(OC)c1",
        "output": "707"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.CCC(O)CC.N#Cc1ccc(O)c(Cl)c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCC(CC)Oc1ccc(C#N)cc1Cl",
        "output": "846"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)c1ccc(N2C(=O)CCc3ccccc32)cc1.[Na+].[OH-]>>O=C(O)c1ccc(N2C(=O)CCc3ccccc32)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nn1nc(-c2ccc(C(F)(F)F)cc2)c2ccccc2c1=O.O=C(Cl)CC12CC3CC(CC(C3)C1)C2>>O=C(CC12CC3CC(CC(C3)C1)C2)Nn1nc(-c2ccc(C(F)(F)F)cc2)c2ccccc2c1=O",
        "output": "450"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(CNc2nccc(-c3ccc(OCCN4CCOCC4)cc3)n2)cc1.Cl.O.[Na+].[OH-]>>O=C(O)c1ccc(CNc2nccc(-c3ccc(OCCN4CCOCC4)cc3)n2)cc1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.COc1cc2cc(Nc3cc(C)[nH]n3)nc(Cl)c2cc1Br>>COc1cc2cc(Nc3cc(C)[nH]n3)nc(OC(C)C)c2cc1Br",
        "output": "433"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)Cl.NCc1ccccc1.O.O=C(O)c1cccc2c([N+](=O)[O-])cccc12>>O=C(NCc1ccccc1)c1cccc2c([N+](=O)[O-])cccc12",
        "output": "753"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1C2CCC1CNC2.Nc1ccc(C(=O)O)nn1>>CC(C)(C)OC(=O)N1C2CCC1CN(C(=O)c1ccc(N)nn1)C2",
        "output": "663"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN.CO.Cc1cc(Cl)nc(Cl)n1.ClCCl>>CNc1cc(C)nc(Cl)n1",
        "output": "166"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C1CCc2cc(OCCCCSc3cc(Br)ccc3Br)ccc2N1.OO>>O=C1CCc2cc(OCCCCS(=O)c3cc(Br)ccc3Br)ccc2N1",
        "output": "199"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C(=O)OC(C)(C)C)C1CNCC1c1ccc(Cl)c(Cl)c1.O=C(O)C1CCN(CC2CC2)CC1>>CN(C(=O)OC(C)(C)C)C1CN(C(=O)C2CCN(CC3CC3)CC2)CC1c1ccc(Cl)c(Cl)c1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOP(=O)(OCC)On1nnc2ccccc2c1=O.COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(-c2ccccn2)cc1)C[C@H](O)[C@@H](N)Cc1ccccc1)C(C)(C)C.Cc1cccc(C)c1OCC(=O)O>>COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(-c2ccccn2)cc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)COc1c(C)cccc1C)C(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cl.N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1.O=C(O)CN1CCN(c2ccc(F)cc2)CC1>>O=C(CN1CCN(c2ccc(F)cc2)CC1)N[C@@H](COCc1ccccc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1",
        "output": "133"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(O)cc1.CN(C)C=O.Fc1ccccc1CBr.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N[C@@H]1C[C@H]1c1ccc(OCc2ccccc2F)cc1",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCOC(=O)[C@H](CCCCCCCCN)N[C@H]1COc2ccccc2N(CC(=O)O)C1=O.CO.Cl.Cl.O.[Na+].[OH-]>>NCCCCCCCC[C@H](N[C@H]1COc2ccccc2N(CC(=O)O)C1=O)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COCCOC.COc1ccc(C=O)cc1B(O)O.Clc1nc2ccccc2[nH]1.O=C([O-])[O-].[Na+].[Na+]>>COc1ccc(C=O)cc1-c1nc2ccccc2[nH]1",
        "output": "874"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COc1cc(C(N)=O)ccc1[N+](=O)[O-].Cl[Ni]Cl.O.O.O.O.O.O.O.[BH4-].[Na+]>>COc1cc(C(N)=O)ccc1N",
        "output": "28"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(=O)c1ccc(OC(C)(C)C(=O)OC)cc1.CO.[BH4-].[Na+]>>CCC(O)c1ccc(OC(C)(C)C(=O)OC)cc1",
        "output": "24"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CC(O)C1.CC(C)(C)[O-].CN(C)C=O.Fc1ccc(Br)c(F)c1.[K+]>>CC(C)(C)OC(=O)N1CC(Oc2cc(F)ccc2Br)C1",
        "output": "485"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCCCc1ccc(C(=O)O)cc1.CCN(CC)CC.C[n+]1ccccc1Cl.Cl.Cl.N[C@@H]1CN2CCC1CC2.O.[I-]>>CCCCc1ccc(C(=O)N[C@@H]2CN3CCC2CC3)cc1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cc(Cl)ncn2)CC1.Cc1ccccc1.O.O=C([O-])[O-].OB(O)c1ccc(F)cc1.[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCN(c2cc(-c3ccc(F)cc3)ncn2)CC1",
        "output": "884"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)CCCCCCC(=O)O.CCCCCC.O.OCc1ccc(O)cc1>>CC(C)CCCCCCC(=O)OCc1ccc(O)cc1",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCNCc1ccc([N+](=O)[O-])cc1.ClCCl>>CCN(Cc1ccc([N+](=O)[O-])cc1)C(=O)OC(C)(C)C",
        "output": "867"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(OS(=O)(=O)C(F)(F)F)nc1.CCOC(C)=O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>O=S(=O)(Oc1ccc(CO)cn1)C(F)(F)F",
        "output": "383"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Nc1ccc2c(c1)NC(=O)C2CC(C)C.CC(=O)OC(C)=O.O=[N+]([O-])O>>CC(=O)Nc1cc2c(cc1[N+](=O)[O-])C(CC(C)C)C(=O)N2",
        "output": "21"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CNC(=O)c1cccc(F)c1Nc1nc(Cl)ncc1Cl.COCCN1CCc2ccc(N)cc2CC1>>CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)CCN(CCOC)CC3)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.NCC(O)COc1ccc(F)cc1>>CC(C)(C)OC(=O)NCC(O)COc1ccc(F)cc1",
        "output": "631"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Oc1ccc(N2C(=O)c3ccccc3C2=O)c([N+](=O)[O-])c1.CCOC(C)=O.[H][H].[Pd]>>CC(C)(C)[Si](C)(C)Oc1ccc(N2C(=O)c3ccccc3C2=O)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccccc1.Cc1ccnc(CO)c1.Clc1cc(-c2cccnc2)c2c(n1)CCCC2.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>Cc1ccnc(COc2cc(-c3cccnc3)c3c(n2)CCCC3)c1",
        "output": "433"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCN.CO.ClCCCl.O=Cc1cc(-c2ccccc2CCNS(=O)(=O)c2ccccc2)ccc1[N+](=O)[O-].[Na+]>>CCCNCc1cc(-c2ccccc2CCNS(=O)(=O)c2ccccc2)ccc1[N+](=O)[O-]",
        "output": "468"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N(C)C.CN(C)C=O.ClCCl.N.O=C(Cl)C(=O)Cl.O=C(O)c1ccc2c(c1)-c1nc(-c3ncnn3-c3ccccc3Cl)cn1CCO2>>NC(=O)c1ccc2c(c1)-c1nc(-c3ncnn3-c3ccccc3Cl)cn1CCO2",
        "output": "358"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.O=C(O)Cc1oc2cccc-2cc1-c1ccccc1.O=S(=O)(O)O>>CCOC(=O)Cc1oc2cccc-2cc1-c1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.COc1cccc(-c2ccc3ccc(N)nc3n2)c1.O.O=C(O)c1cccc(Br)c1>>COc1cccc(-c2ccc3ccc(NC(=O)c4cccc(Br)c4)nc3n2)c1",
        "output": "744"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCC.CCc1cc(Br)cc2c(C)n[nH]c12.CN(C)C=O.Cl.O=C([O-])O.[H-].[Li]C(C)(C)C.[Na+].[Na+]>>CCc1cc(C=O)cc2c(C)n[nH]c12",
        "output": "638"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C(=O)OC)(c1ccc(C(F)(F)F)cc1)n1ncc2c([N+](=O)[O-])cc(F)cc21.CO.[Ni]>>CCC(C(=O)OC)(c1ccc(C(F)(F)F)cc1)n1ncc2c(N)cc(F)cc21",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccccc1CC(=O)Nc1ccc(C(=O)O)cn1.O=S(Cl)Cl>>Cc1ccccc1CC(=O)Nc1ccc(C(=O)Cl)cn1",
        "output": "188"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CN(C)C=O.Nc1ccc(F)cc1.O=C(O)c1c(Cl)cc(Cl)c(O)c1[N+](=O)[O-].O=C(n1ccnc1)n1ccnc1>>O=C(Nc1ccc(F)cc1)c1c(Cl)cc(Cl)c(O)c1[N+](=O)[O-]",
        "output": "50"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COCCn1c(=O)sc2ccc(Br)cc21.[K+]>>COCCn1c(=O)sc2ccc(B3OC(C)(C)C(C)(C)O3)cc21",
        "output": "934"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.Cc1ccc(C(=O)NC2CC2)cc1-n1cnc2ccc(OCCN)cc2c1=O.ClCCl>>Cc1ccc(C(=O)NC2CC2)cc1-n1cnc2ccc(OCCNS(C)(=O)=O)cc2c1=O",
        "output": "493"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrBr.CC(=O)O.CC(=O)c1ccc([N+](=O)[O-])cc1>>O=C(CBr)c1ccc([N+](=O)[O-])cc1",
        "output": "173"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)O.CC(C)(C)[Si](C)(C)OCc1ncc2n1C(=O)N(C1CCN(Cc3ccccc3)CC1)C2.O>>O=C1N(C2CCN(Cc3ccccc3)CC2)Cc2cnc(CO)n21",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CNS(=O)(=O)c1cccc(N)c1.O=C(O)c1cnn2c(C(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12>>CNS(=O)(=O)c1cccc(NC(=O)c2cnn3c(C(F)F)cc(-c4ccc(C(F)(F)F)cc4)nc23)c1",
        "output": "969"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)N=NC(=O)OCC.O=[N+]([O-])c1ccc(O)cc1C(F)(F)F.OCC1CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=[N+]([O-])c1ccc(OCC2CC2)cc1C(F)(F)F",
        "output": "478"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.Cn1nccc1-c1csc(C(=O)NC(CNC(=O)OC(C)(C)C)Cc2ccccc2)n1.O=C(O)C(F)(F)F>>Cn1nccc1-c1csc(C(=O)NC(CN)Cc2ccccc2)n1",
        "output": "538"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1noc(-c2ccc(Br)cc2)c1NC1CCN(Cc2ccccc2)CC1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4NC4CCN(Cc5ccccc5)CC4)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)SCC(Cc1ccccc1)C(=O)O.CCN(C(C)C)C(C)C.CCOCC.CN(C)C=O.COC(=O)CCCN.Cl.ClCCl.O=C(Cl)C(=O)Cl>>COC(=O)CCCNC(=O)C(CSC(C)=O)Cc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.CCN(C(C)C)C(C)C.ClCCl.Cn1cc(-c2ccc(-c3cncc4ccc(N)cc34)cc2)cn1>>CC(=O)Nc1ccc2cncc(-c3ccc(-c4cnn(C)c4)cc3)c2c1",
        "output": "6"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)COc1ccc(C(=O)Cl)cc1.Cc1ccccc1.Nc1ccccc1Sc1cccc(O)c1-c1nnn[nH]1>>CCOC(=O)COc1ccc(C(=O)Nc2ccccc2Sc2cccc(O)c2-c2nnn[nH]2)cc1",
        "output": "11"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)c1cc(B2OC(C)(C)C(C)(C)O2)cnc1OC.Cn1cc(-n2c(=O)n(C)c3cnc4ccc(Br)cc4c32)c(Cl)n1>>COC(=O)c1cc(-c2ccc3ncc4c(c3c2)n(-c2cn(C)nc2Cl)c(=O)n4C)cnc1OC",
        "output": "954"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)c1ccncc1.COc1cccc(C(CO)CC(=O)NN=C(c2ccccc2)c2ccccc2)c1.CS(=O)(=O)Cl.ClCCl.c1ccncc1>>COc1cccc(C(COS(C)(=O)=O)CC(=O)NN=C(c2ccccc2)c2ccccc2)c1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.COCCOc1c(OC)cc(C#N)c([N+](=O)[O-])c1F.O.O=S([O-])S(=O)[O-].[Na+].[Na+]>>COCCOc1c(OC)cc(C#N)c(N)c1F",
        "output": "202"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.c1ccc(-c2cccnc2-c2ccccc2)cc1>>[O-][n+]1cccc(-c2ccccc2)c1-c1ccccc1",
        "output": "262"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(C=O)cc1O.Nc1c(F)cc(F)cc1F>>COc1ccc(CNc2c(F)cc(F)cc2F)cc1O",
        "output": "359"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.NN.O=C1c2ccccc2C(=O)N1CCOCc1ccccc1>>NCCOCc1ccccc1",
        "output": "242"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CN(C)CCN.Fc1ccc(N2CCNCC2)cc1.O=C(n1ccnc1)n1ccnc1>>CN(C)CCNC(=O)N1CCN(c2ccc(F)cc2)CC1",
        "output": "734"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(c2cc(CO)ccn2)OCCO1.CCN(CC)CC.CN(C)c1ccncc1.CS(=O)(=O)Cl.ClCCl.N#N>>CC1(c2cc(COS(C)(=O)=O)ccn2)OCCO1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C(OC(C)(C)C)OC(C)(C)C.Cc1ccccc1.O=C(O)c1ccc(F)c(O)c1>>CC(C)(C)OC(=O)c1ccc(F)c(O)c1",
        "output": "768"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CNOC.COc1ccc(C(=O)O)cn1.Cl.Cl.On1nnc2cccnc21>>COc1ccc(C(=O)N(C)OC)cn1",
        "output": "879"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CC1(C)c2ccccc2-c2ccc(Br)cc21.[K+]>>CC1(C)c2ccccc2-c2ccc(B3OC(C)(C)C(C)(C)O3)cc21",
        "output": "942"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN.CO.O=Cc1cc(Cl)cc2ccccc12.[BH4-].[K+]>>CNCc1cc(Cl)cc2ccccc12",
        "output": "468"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.c1ccc2c(c1)CCCN2>>CC(C)(C)OC(=O)N1CCCc2ccccc21",
        "output": "827"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.Clc1ccnc2[nH]cc(Br)c12.O=S(=O)(Cl)c1ccccc1.[H-].[Na+]>>O=S(=O)(c1ccccc1)n1cc(Br)c2c(Cl)ccnc21",
        "output": "354"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.Clc1ccc2c(n1)O[C@H](c1ccccc1)CNC2>>CC(C)(C)OC(=O)N1Cc2ccc(Cl)nc2O[C@H](c2ccccc2)C1",
        "output": "694"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#Cc1csc2c(NCc3ccccc3)nc(Cl)nc12.C1COCCO1.CCOC(C)=O.C[C@H](O)CN>>C#Cc1csc2c(NCc3ccccc3)nc(NC[C@H](C)O)nc12",
        "output": "544"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3c(CO)cnc4ccc(Br)cc34)cc2C(F)(F)F)CC1.CCOC(C)=O.ClCCl>>CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3c(C=O)cnc4ccc(Br)cc34)cc2C(F)(F)F)CC1",
        "output": "520"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COc1ccc2ccccc2c1C=O.C[N+](=O)[O-].Cl.[Na+].[OH-]>>COc1ccc2ccccc2c1C=C[N+](=O)[O-]",
        "output": "282"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1c[nH]c2cccc(C(F)(F)F)c2c1=O.[Na+].[OH-].[Pd]>>O=C(O)c1c[nH]c2cccc(C(F)(F)F)c2c1=O",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(Oc1cc(Oc2ccc(Br)cc2C#N)ccc1Br)C(=O)Cl.CCCCNCc1ccco1.ClCCl>>CCCCN(Cc1ccco1)C(=O)C(C)Oc1cc(Oc2ccc(Br)cc2C#N)ccc1Br",
        "output": "125"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(Cn2nc(-c3ccc(F)cc3)c3c(Oc4ccc(-c5cnc(Nc6ccccc6)n(C)c5=O)cc4F)ccnc32)cc1.O=C(O)C(F)(F)F>>Cn1c(Nc2ccccc2)ncc(-c2ccc(Oc3ccnc4[nH]nc(-c5ccc(F)cc5)c34)c(F)c2)c1=O",
        "output": "978"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)ON1CCC(O)CC1.CCCCI.CN(C)C=O.O.[H-].[Na+]>>CCCCOC1CCN(OC(=O)OC(C)(C)C)CC1",
        "output": "307"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Nc1cccc2c1CCNC2C.O=C(O)c1cc2ncc(Br)cn2n1>>CC(=O)Nc1cccc2c1CCN(C(=O)c1cc3ncc(Br)cn3n1)C2C",
        "output": "952"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=CCOc1ccc(O)cc1.CC(C)OC(=O)NCCCl>>CC(C)=CCOc1ccc(OCCNC(=O)OC(C)C)cc1",
        "output": "74"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCOC1=Nc2sccc2C(=CN)N1CCC.O=C1CCC(=O)N1Br.c1ccncc1>>CCCOC1=Nc2sc(Br)cc2C(=CN)N1CCC",
        "output": "807"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCN1CCN(C(=O)OC(C)(C)C)CC1.O=C(O)C(F)(F)F>>C#CCN1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COc1ccc2[nH]c(C)c(C(C)(C)C(=O)O)c2c1.C[Si](C)(C)[N-][Si](C)(C)C.Cl.O=C(Cl)c1ccc(Cl)cc1.[Cl-].[K+].[NH4+]>>COc1ccc2c(c1)c(C(C)(C)C(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1",
        "output": "232"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccc(Br)cc1.CCC(C)=O.O=C([O-])[O-].O=C1Nc2ccccc2C12COc1cc3c(cc12)CCO3.[Cs+].[Cs+]>>O=C1N(Cc2ccc(Br)cc2)c2ccccc2C12COc1cc3c(cc12)CCO3",
        "output": "688"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.O=C1c2ccccc2CCc2ccc(Cl)cc21.[BH4-].[Na+]>>OC1c2ccccc2CCc2ccc(Cl)cc21",
        "output": "157"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)N.N#Cc1cccc(CBr)c1>>CC(C)NCc1cccc(C#N)c1",
        "output": "446"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)CCN1C(=O)C(Cc2ccccc2)Oc2c(C)cc(C)cc21.[Na+].[OH-]>>Cc1cc(C)c2c(c1)N(CCC(=O)O)C(=O)C(Cc1ccccc1)O2",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COc1ccc2[nH]c(C3CN(c4cc(-c5ccc(C#N)c(F)c5)nc(N)n4)CCO3)nc2c1.NN.O.O>>COc1ccc2[nH]c(C3CN(c4cc(-c5ccc6c(N)n[nH]c6c5)nc(N)n4)CCO3)nc2c1",
        "output": "945"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1ccc(S(=O)(=O)N[C@@H](C)CC#C[Si](C)(C)C)cc1.O=C([O-])[O-].[K+].[K+]>>C#CC[C@H](C)NS(=O)(=O)c1ccc(C)cc1",
        "output": "337"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(=O)OCC1=C(C(=O)OC(C)(C)C)N2C(=O)C(N)[C@H]2SC1.ClC(Cl)Cl.O=C(O)C(=NOC1CCCCO1)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1>>CC(=O)OCC1=C(C(=O)OC(C)(C)C)N2C(=O)C(NC(=O)C(=NOC3CCCCO3)c3csc(NC(c4ccccc4)(c4ccccc4)c4ccccc4)n3)[C@H]2SC1",
        "output": "587"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CCOC(=O)c1cc(OCCCC(=O)OC)c(Cl)nc1C.CCOC(C)=O.Cl.O=C(NS(=O)(=O)Cc1ccccc1)C1CCNCC1.[Cl-].[NH4+]>>CCOC(=O)c1cc(OCCCC(=O)OC)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccccc3)CC2)nc1C",
        "output": "220"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)[C@@H]1CC(F)(F)CC[C@H]1c1oc(C(F)(F)C(F)(F)F)nc1-c1ccc(C(=O)N2CCOCC2)cc1.O.O=S(=O)(O)O>>O=C(O)[C@@H]1CC(F)(F)CC[C@H]1c1oc(C(F)(F)C(F)(F)F)nc1-c1ccc(C(=O)N2CCOCC2)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCOC(C)=O.COCCOc1cc(CC(N)C2(C)CC2)ccc1OC.O=CO>>COCCOc1cc(CC(NC=O)C2(C)CC2)ccc1OC",
        "output": "370"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(=O)OC(C)=O.CC(C)Cc1ccc(N)cc1.O>>CC(=O)Nc1ccc(CC(C)C)cc1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)c1ccc(-c2nc3ncc(N)cc3[nH]2)cc1.CN(C)c1ccc(C(=O)O)cc1>>CN(C)c1ccc(C(=O)Nc2cnc3nc(-c4ccc(N(C)C)cc4)[nH]c3c2)cc1",
        "output": "759"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cn(Cc2ccc(OCc3coc(-c4ccccc4)n3)cc2)nc1-c1cccs1.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>OCc1cn(Cc2ccc(OCc3coc(-c4ccccc4)n3)cc2)nc1-c1cccs1",
        "output": "471"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C[C@H](O)C(=O)O.CCN(CC)CC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cc1ccc2c(N3CCNCC3)nc(-c3ccccc3O)nc2c1.F[P-](F)(F)(F)(F)F>>Cc1ccc2c(N3CCN(C(=O)[C@@H](O)CC(C)C)CC3)nc(-c3ccccc3O)nc2c1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)c1ccccc1CN1CN(c2ccccc2)C2(CCNCC2)C1=O.CC1(F)C(=O)N(CCCCl)c2ccccc21.CCC(C)=O.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CC(C)(C)OC(=O)c1ccccc1CN1CN(c2ccccc2)C2(CCN(CCCN3C(=O)C(C)(F)c4ccccc43)CC2)C1=O",
        "output": "138"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.ClCCl.NCCc1ccc(F)c(Cl)c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(NCCc1ccc(F)c(Cl)c1)C(F)(F)F",
        "output": "316"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1ccc(Oc2cccc([C@@H]3COC4(CCNCC4)C3)c2)nc1.CC#N.CCN(C(C)C)C(C)C.Cl.O=C(Nc1cccnc1)Oc1ccccc1>>O=C(Nc1cccnc1)N1CCC2(CC1)C[C@H](c1cccc(Oc3ccc(Br)cn3)c1)CO2",
        "output": "525"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCC.CCOC(C)=O.CI.CN(C)C=O.O.O=[N+]([O-])c1ccc(F)cc1O.[H-].[Na+]>>COc1cc(F)ccc1[N+](=O)[O-]",
        "output": "62"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCCCCCN(Cc1cn2ccccc2n1)C1CCCc2cccnc21.CO.O=C(O)C(F)(F)F>>NCCCCCN(Cc1cn2ccccc2n1)C1CCCc2cccnc21",
        "output": "538"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COc1c(-c2nnco2)cc(C(C)(C)C)cc1[N+](=O)[O-].O.[Cl-].[Fe].[NH4+]>>COc1c(N)cc(C(C)(C)C)cc1-c1nnco1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)OB(c2cn[nH]c2)OC1(C)C.CNCCC(c1ccc(Cl)cc1)c1ccc(Br)cc1>>CNCCC(c1ccc(Cl)cc1)c1ccc(-c2cn[nH]c2)cc1",
        "output": "971"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)O.CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc(-c3ccnc(N4CCN(CC)CC4)c3)sc2c1-c1ccc(Cl)cc1.CN(C)C=O.CO.[Na+].[OH-]>>CCN1CCN(c2cc(-c3nc4cc(C)c([C@H](OC(C)(C)C)C(=O)O)c(-c5ccc(Cl)cc5)c4s3)ccn2)CC1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(OCC)[C@H](C)N(Cc1csc2ccccc12)C(=O)[C@@H](N)CC(=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1.CN(CC(=O)O)NC(=O)NCc1ccc(Cl)cc1>>CCOC(OCC)[C@H](C)N(Cc1csc2ccccc12)C(=O)[C@H](CC(=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1)NC(=O)CN(C)NC(=O)NCc1ccc(Cl)cc1",
        "output": "133"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CS(C)=O.[I-].[N-]=[N+]=[N-].[Na+].[Na+]>>[N-]=[N+]=NCc1ccccc1",
        "output": "643"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC1CCNCC1.Cl.Cl.ClCCl.O=C(Cl)CCl>>COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC1CCN(C(=O)CCl)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCc2ccc(-n3nc(C(C)(C)C)cc3NC(=O)Nc3cccc(C#N)c3)cc2C1.CCOC(C)=O.CCOC(C)=O.CCOCC.Cl>>CC(C)(C)c1cc(NC(=O)Nc2cccc(C#N)c2)n(-c2ccc3c(c2)CNCC3)n1",
        "output": "887"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1noc(-c2ccc(Br)cc2)c1[C@@H](O)c1cn(Cc2ccccc2Cl)nn1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4[C@@H](O)c4cn(Cc5ccccc5Cl)nn4)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)OC(=O)Cl.CCN(CC)CC.Cc1cn(-c2ccc(S(C)(=O)=O)cc2)c(=O)cc1OC1CCNCC1.ClCCl>>Cc1cn(-c2ccc(S(C)(=O)=O)cc2)c(=O)cc1OC1CCN(C(=O)OC(C)C)CC1",
        "output": "219"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CC(O)(C(=O)O)C(F)(F)F.CCN(C(C)C)C(C)C.CN(C)S(=O)(=O)c1ccc(N)cc1.O.O=S(Cl)Cl.c1cc(N2CCCC2)ccn1>>CN(C)S(=O)(=O)c1ccc(NC(=O)C(C)(O)C(F)(F)F)cc1",
        "output": "365"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CN.COc1nc(C2=NN(c3ccc(C#N)c(C)n3)[C@@H](C3CCCC3)C2)ccc1C(=O)O>>CNC(=O)c1ccc(C2=NN(c3ccc(C#N)c(C)n3)[C@@H](C3CCCC3)C2)nc1OC",
        "output": "674"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.C.CC(=O)O.ClCCl.O=C(O)CCCCCCCCCCCCCCCO.O=S(=O)(O)O>>O=C(O)CCCCCCCCCCCCCCCBr",
        "output": "224"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)CCCCCBr.CN(C)C=O.O.O=C([O-])[O-].Oc1ccc2c(c1)[nH]c1ccccc12.[K+].[K+]>>CCOC(=O)CCCCCOc1ccc2c(c1)[nH]c1ccccc12",
        "output": "75"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cccc(F)c1CN1CCCC(NC(=O)OC(C)(C)C)C1=O.Cc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>COc1cccc(F)c1CN1CCCC(N)C1=O",
        "output": "431"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)NS(=O)(=O)c1ccc(-c2cn(-c3nc(-c4cccc(Cl)c4)cc(C(F)(F)F)n3)cn2)s1.ClCCl.O=C(O)C(F)(F)F>>NS(=O)(=O)c1ccc(-c2cn(-c3nc(-c4cccc(Cl)c4)cc(C(F)(F)F)n3)cn2)s1",
        "output": "680"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN1CCC2(CCNCC2)C1=O.Cl.ClCCl.O=S(=O)(Cl)c1ccc(OC(F)(F)F)cc1>>CN1CCC2(CCN(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)CC2)C1=O",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.Cc1ccc2c(N3CCN(CCc4cccc(Br)c4O)CC3)cccc2n1.NC(=O)CBr.O=C([O-])[O-].[K+].[K+]>>Cc1ccc2c(N3CCN(CCc4cccc(Br)c4OCC(N)=O)CC3)cccc2n1",
        "output": "778"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cn(C2CC2)c2nc3cc(F)c(F)cc3cc2c1=O.c1coc(C2CNCCN2)c1>>CCOC(=O)c1cn(C2CC2)c2nc3cc(N4CCNC(c5ccco5)C4)c(F)cc3cc2c1=O",
        "output": "676"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.CSc1nc(-c2ccccc2)n(-c2ccc(C)c(C)c2)c(=O)c1C#N.O=S(=O)(O)Cl>>CSc1nc(-c2ccc(S(=O)(=O)Cl)cc2)n(-c2ccc(C)c(C)c2)c(=O)c1C#N",
        "output": "182"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)C[C@@H]1CN(C2CCCC2)C(=O)N1C1CCNCC1.Cc1nc(Oc2ccc(C(=O)OC(C)(C)C)cc2)ccc1C=O>>Cc1nc(Oc2ccc(C(=O)OC(C)(C)C)cc2)ccc1CN1CCC(N2C(=O)N(C3CCCC3)C[C@H]2CC(C)C)CC1",
        "output": "757"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.O=C(O)c1ccc[nH]1.O=C([O-])C(F)(F)F.[NH3+]CCNC(=O)c1cnn2cc(Cc3ccc(Br)cc3)cnc12>>O=C(NCCNC(=O)c1cnn2cc(Cc3ccc(Br)cc3)cnc12)c1ccc[nH]1",
        "output": "137"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)Cc1ccc(C#N)cc1Cl.Cl.NO.O=C([O-])O.[Na+]>>COC(=O)Cc1ccc(C(=N)NO)cc1Cl",
        "output": "854"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CCCCCO.Cc1ccc(S(=O)(=O)Cl)cc1.O.c1ccncc1>>C#CCCCCOS(=O)(=O)c1ccc(C)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N1CCC(CC(=O)O)CC1.O=CN1CCc2ccccc2CC1>>CC(=O)N1CCC(CC(=O)c2ccc3c(c2)CCN(C=O)CC3)CC1",
        "output": "435"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN[C@H](CC1CCCCC1)CN1CCN(c2cccc3[nH]ccc23)CC1.ClCCl.O=C(Cl)C1CCCCC1>>CN(C(=O)C1CCCCC1)[C@H](CC1CCCCC1)CN1CCN(c2cccc3[nH]ccc23)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)CCc1ccc(Oc2cc(C)cc(Oc3ccc(C(F)(F)F)cc3Oc3ccccc3)c2)cc1C.Cl.O.[Na+].[OH-]>>Cc1cc(Oc2ccc(CCC(=O)O)c(C)c2)cc(Oc2ccc(C(F)(F)F)cc2Oc2ccccc2)c1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "B.C1CCOC1.C1CCOC1.O=C(O)c1ccc2cccc(Br)c2c1>>OCc1ccc2cccc(Br)c2c1",
        "output": "72"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)c1cc(N)cc(Cl)c1Sc1nc2cc(Cl)ccc2s1.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1Cl.c1ccncc1>>CC(=O)c1cc(NS(=O)(=O)c2ccc(C(F)(F)F)cc2Cl)cc(Cl)c1Sc1nc2cc(Cl)ccc2s1",
        "output": "68"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OC(C)=O.CC(=O)[O-].COC(=O)[C@H]1C(C)=C[C@H](O)CC12CCCC2.[Na+].[Na+].[OH-]>>COC(=O)[C@H]1C(C)=C[C@H](OC(C)=O)CC12CCCC2",
        "output": "155"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1ccc(Nc2nc(Br)cn3ccnc23)cc1.[Na+].[OH-]>>O=C(O)c1ccc(Nc2nc(Br)cn3ccnc23)cc1",
        "output": "5"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.COc1ccc(Cl)cc1N1CCN(CC(O)CNc2nccc(C(=O)NCCN)n2)CC1.NC(=O)c1ccnc(Cl)n1.O=C([O-])[O-].[K+].[K+]>>COc1ccc(Cl)cc1N1CCN(CC(O)CNc2nccc(C(=O)NCCNc3nccc(C(N)=O)n3)n2)CC1",
        "output": "544"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.CN(C)C=O.COC(=O)c1nc2c(ncn2C)c(F)c1Nc1ccccc1F.O=C1CCC(=O)N1Br>>COC(=O)c1nc2c(ncn2C)c(F)c1Nc1ccc(Br)cc1F",
        "output": "4"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C(=O)Nc1cc(C#N)ccc1CCCC(=O)O)c1cccc2ccccc12.CN(C)C=O.O.O=C([O-])[O-].OCCI.[K+].[K+]>>CC(C(=O)Nc1cc(C#N)ccc1CCCC(=O)OCCO)c1cccc2ccccc12",
        "output": "196"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)O.CCCCN=C=O.CCOCC.NCCN>>CCCCNC(=O)NCCN",
        "output": "244"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)c1sc(C(=O)NCc2cccc3[nH]ccc23)cc1C.O.O.[Li]O>>Cc1cc(C(=O)NCc2cccc3[nH]ccc23)sc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCCCCCCCBr.N#Cc1ccc(O)cc1.[K]>>N#Cc1ccc(OCCCCCCCBr)cc1",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)C=Cc1ccc(C(F)(F)F)cc1OC(C)C.Cl.[Li+].[OH-]>>CC(C)Oc1cc(C(F)(F)F)ccc1C=CC(=O)O",
        "output": "58"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)OC(=O)Nc2ccc(OCCCCCl)cc21.Cc1ccc(S)cc1>>Cc1ccc(SCCCCOc2ccc3c(c2)C(C)(C)OC(=O)N3)cc1",
        "output": "460"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.O=P(Cl)(Cl)Cl.O=c1[nH]ccc(-c2ccc(Cl)cc2Cl)c1[N+](=O)[O-]>>O=[N+]([O-])c1c(-c2ccc(Cl)cc2Cl)ccnc1Cl",
        "output": "100"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.O.O=C(O)c1ccc(I)cc1O>>OCc1ccc(I)cc1O",
        "output": "72"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(=O)c1c(Cl)c2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc2n1C.CO.Cl.O.[Li+].[OH-]>>Cn1c(C(=O)O)c(Cl)c2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc21",
        "output": "171"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCc1cccc(-c2nc3c(N4CCN(CC(=O)Nc5nccs5)CC4)c(Br)cnc3[nH]2)c1.ClCCl.O=C(O)C(F)(F)F>>NCc1cccc(-c2nc3c(N4CCN(CC(=O)Nc5nccs5)CC4)c(Br)cnc3[nH]2)c1",
        "output": "793"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cl.Cl[Sn]Cl.O.O.O=[N+]([O-])c1cc(Cl)c2scnc2c1.[Na+].[OH-]>>Nc1cc(Cl)c2scnc2c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "N.O.O=S(=O)(c1ccc(Cl)nc1)N1CCCCC1>>Nc1ccc(S(=O)(=O)N2CCCCC2)cn1",
        "output": "388"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCNCC3)cc1.CS(=O)(=O)Cl.ClC(Cl)Cl>>CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(S(C)(=O)=O)CC3)cc1",
        "output": "584"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCBr.OCc1c(F)cc(O)cc1F>>CCOc1cc(F)c(CO)c(F)c1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)c1ccc(N)cc1.COc1cn(C(CC2CC2)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1C#N>>COc1cn(C(CC2CC2)C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N",
        "output": "710"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CN1CCC(N)CC1.O=C(O)c1n[nH]cc1NC(=O)c1c(F)cccc1F.On1nnc2ccccc21>>CN1CCC(NC(=O)c2n[nH]cc2NC(=O)c2c(F)cccc2F)CC1",
        "output": "816"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCc1ccccc1.CN(C)C=O.O.O=C([O-])[O-].O=c1[nH]cc(Br)c(=O)[nH]1.[K+].[K+]>>O=c1[nH]c(=O)n(Cc2ccccc2)cc1Br",
        "output": "389"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Nc1ccc(C(F)(F)F)c(F)c1.II.O=S([O-])O.[Cl-].[Li]CCCC.[NH4+].[Na+]>>CC(C)(C)OC(=O)Nc1ccc(C(F)(F)F)c(F)c1I",
        "output": "372"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)C2CC[C@]1(C)CNC2.CC1CCC(CC(=O)O)CC1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.ClCCl>>CC1CCC(CC(=O)N2CC3CC[C@](C)(C2)C3(C)C)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(C)(C)C(=O)Nc1nc2ccc3ccc(Br)c([N+](=O)[O-])c3c2c(=O)[nH]1.CCO.ClC(Cl)Cl.O.O=C([O-])O.[Fe].[Na+]>>CC(C)(C)C(=O)Nc1nc2ccc3ccc(Br)c(N)c3c2c(=O)[nH]1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1ccccn1.C#CCOC.CCNCC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.I[Cu]I>>COCC#Cc1ccccn1",
        "output": "777"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.COc1cc(C(=O)O)ccc1Cc1cn(CCC(N)=O)c2ccc(C(=O)NCC3CCCC3)cc12.Cc1ccccc1S(N)(=O)=O.Cl.ClCCl>>COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(CCC(N)=O)c2ccc(C(=O)NCC3CCCC3)cc12",
        "output": "579"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)CCc1ccc(OC)cc1CN(CC(F)(F)F)C(=O)OC(C)(C)C.Cl.[Na+].[OH-]>>COc1ccc(CCC(=O)O)c(CN(CC(F)(F)F)C(=O)OC(C)(C)C)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COC(=O)CSc1cccc(C(OC2CCN(C)CC2)c2nc3ccccc3s2)c1.NN.O>>CN1CCC(OC(c2cccc(SCC(=O)NN)c2)c2nc3ccccc3s2)CC1",
        "output": "130"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1cc2c(o1)CN(C(=O)c1ccc(C(=O)c3ccccc3)cc1)CC2.Cl.[Na+].[OH-]>>O=C(c1ccccc1)c1ccc(C(=O)N2CCc3cc(C(=O)O)oc3C2)cc1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.C[C@H](N)c1nc2cccc(Cl)c2c(=O)n1-c1cccnc1.N#Cc1c(N)nc(N)nc1Cl.[F-].[K+]>>C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cccnc1",
        "output": "110"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCBr.CN(C)C=O.O.Sc1ccc(Br)cc1.[H-].[Na+]>>CCCSc1ccc(Br)cc1",
        "output": "124"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.ClCCl.OCCBr.c1c[nH]cn1>>CC(C)(C)[Si](OCCBr)(c1ccccc1)c1ccccc1",
        "output": "602"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1nc2c(C(F)(F)F)cccn2c1-c1cccc(O)c1.CN(C)C=O.O.O=C([O-])[O-].O=S(=O)(c1cccc(F)c1)C(F)(F)F.[K+].[K+]>>CC(C)c1nc2c(C(F)(F)F)cccn2c1-c1cccc(Oc2cccc(S(=O)(=O)C(F)(F)F)c2)c1",
        "output": "564"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.Cn1c(=O)n(CC(C)(C)C)c2ccc([C@@H]3C[C@H]3CO)nc21>>Cn1c(=O)n(CC(C)(C)C)c2ccc([C@@H]3C[C@H]3COS(C)(=O)=O)nc21",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.O=C1CC2(CCC2)c2c(F)cccc2N1>>Fc1cccc2c1C1(CCC1)CCN2",
        "output": "112"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)OC(CC=C(C)C)C(C)CCOC(C)=O.CO.O.O=C([O-])[O-].[K+].[K+]>>CCOC(C)OC(CC=C(C)C)C(C)CCO",
        "output": "225"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1CCCC(Cc2ncn3c2CCc2cc(OS(=O)(=O)C(F)(F)F)ccc2-3)C1=O.O.O=C([O-])[O-].OB(O)c1ccccc1.[Cl-].[Na+].[Na+].[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1CCCC(Cc2ncn3c2CCc2cc(-c4ccccc4)ccc2-3)C1=O",
        "output": "825"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cnc(C2CCN(C(=O)OC(C)(C)C)C2)nc1.ClCCl.O=C(O)C(F)(F)F>>COc1cnc(C2CCNC2)nc1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)n1ncc2cc(-n3nc(C(C)(C)C)cc3NC(=O)Nc3cccc(Cl)c3Cl)ccc21.CCO.Cl.Cl>>CC(C)(C)c1cc(NC(=O)Nc2cccc(Cl)c2Cl)n(-c2ccc3[nH]ncc3c2)n1",
        "output": "896"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN1CCC[C@H]1C(=O)O.CS(C)=O.Cc1cc(C(=O)N[C@@H](CCCCN)c2nc3cc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1>>Cc1cc(C(=O)N[C@@H](CCCCNC(=O)[C@@H]2CCCN2C)c2nc3cc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1",
        "output": "216"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCCC(CCCO)C1.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N1CCCC(CCC=O)C1",
        "output": "142"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.Cc1ccccc1.Cl.N#CCO.O=[N+]([O-])c1cc([N+](=O)[O-])c(F)cc1F>>N#CCOc1cc(F)c([N+](=O)[O-])cc1[N+](=O)[O-]",
        "output": "485"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCC(=O)Cl.CCN(CC)CC.CNc1ccc(CC(NS(=O)(=O)c2cccnc2)c2cccc(N(CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n2)cc1.ClCCl.O.O=C([O-])O.[Na+]>>CCCC(=O)N(C)c1ccc(CC(NS(=O)(=O)c2cccnc2)c2cccc(N(CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)n2)cc1",
        "output": "160"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.O.O.[Li+].[OH-]>>CC(C)(C(=O)O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "203"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)c1nc(Br)ccc1OCc1ccccc1.C[NH+](C)C.Cc1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-].[Cl-]>>CC(=O)c1nc(Br)ccc1O",
        "output": "264"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)n1cc(-c2ccc(N)cc2)c2c(Cl)ncnc21.CCN(CC)CC.ClCCl.O.O=S(=O)(Cl)c1ccccc1>>CC(C)n1cc(-c2ccc(NS(=O)(=O)c3ccccc3)cc2)c2c(Cl)ncnc21",
        "output": "68"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.CSCCCCN1C(=O)CC[C@@H]1/C=C/C(O)Cc1ccccc1.ClCCl.O.O=S([O-])O.O=S([O-])OO.[K+].[Na+]>>CS(=O)(=O)CCCCN1C(=O)CC[C@@H]1/C=C/C(O)Cc1ccccc1",
        "output": "847"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)[O-].CO.Nc1ccnc(N2CCN(C3CCCC3)CC2)n1.O.O=C(Cl)C1CCCC1.[K+]>>O=C(Nc1ccnc(N2CCN(C3CCCC3)CC2)n1)C1CCCC1",
        "output": "332"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrCc1ccccc1.C1CCOC1.COC[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(CO)nc32)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C.[H-].[Na+]>>COC[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(COCc4ccccc4)nc32)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C",
        "output": "464"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.C[C@@H]1CCC(CO)O1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCC2CC[C@@H](C)O2)cc1",
        "output": "197"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(N)(=O)=O.N#CC1(COc2cc(F)c(C(=O)O)cc2C2CC2)C2CC3CC(C2)CC1C3.NS(=O)(=O)N1CCC1.O=C(O)c1cc(C2CC2)c(OCC2CCC3C(C2)C3(F)F)cc1F>>O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC2CCC3C(C2)C3(F)F)cc1F",
        "output": "886"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)CBr.CN(C)C=O.O.O=C([O-])[O-].O=c1nc(-c2ccccn2)sc2ccc(O)cc12.[K+].[K+]>>CC(C)(C)OC(=O)COc1ccc2sc(-c3ccccn3)nc(=O)c2c1",
        "output": "393"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)O.NCC(O)CNC1CC1>>Cc1[nH]c(/C=C2\\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)NCC(O)CNC1CC1",
        "output": "674"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.CN(C)c1ccncc1.Cl.NCCn1c2ccccc2c2cc(C(N)=O)c(N)nc21.c1ccncc1>>CC(=O)NCCn1c2ccccc2c2cc(C(N)=O)c(N)nc21",
        "output": "339"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OCCN3C[C@H](C)O[C@H](C)C3)CC2)c2ncnn12.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n([C@@H]2CC[C@@H](OCCN3C[C@H](C)O[C@H](C)C3)CC2)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOP(=O)(CCCOc1ccc(CCNC(=O)OC(C)(C)C)cc1)OCC.Cl.ClCCl>>CCOP(=O)(CCCOc1ccc(CCN)cc1)OCC",
        "output": "538"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CN(C)c1ccncc1.CO.F[P-](F)(F)(F)(F)F.NCCCn1ccnc1.O=C(COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)Nc1cc(C(=O)O)ccn1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>O=C(COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)Nc1cc(C(=O)NCCCn2ccnc2)ccn1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc2c(c1)C(c1cc(F)cc(F)c1)=C(c1cccnc1)C2=O.COc1ccc2c(c1)C(c1ccccc1)=C(c1ccncc1)C2=O>>O=C1C(c2ccncc2)=C(c2ccccc2)c2cc(O)ccc21",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)CCN1C(=O)C(C(C)C)Oc2ccc(C)cc21.[Na+].[OH-]>>Cc1ccc2c(c1)N(CCC(=O)O)C(=O)C(C(C)C)O2",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2[nH]cnc2n1.c1ccc2c(c1)CC[C@@H]1NCCC[C@H]21>>O=C(c1ccc2[nH]cnc2n1)N1CCC[C@@H]2c3ccccc3CC[C@@H]21",
        "output": "605"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cccc(C(=O)Cl)c1[Se]Cc1ccccc1.Cl.Nc1ccccc1.c1ccncc1>>COc1cccc(C(=O)Nc2ccccc2)c1[Se]Cc1ccccc1",
        "output": "11"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.Nc1ccc(F)c([N+](=O)[O-])c1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(Nc1ccc(F)c([N+](=O)[O-])c1)C(F)(F)F",
        "output": "106"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CSc1cnc(N)s1.CCOC(=O)CSc1cnc(NC(=O)N(CC2CCCC2)c2ccc(S(C)(=O)=O)cc2)s1.CS(=O)(=O)c1ccc(N(CC2CCCC2)C(=O)Nc2nc(CC(=O)O)cs2)cc1.CS(=O)(=O)c1ccc(NCC2CCCC2)cc1>>CS(=O)(=O)c1ccc(N(CC2CCCC2)C(=O)Nc2ncc(SCC(=O)O)s2)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.COC(=O)Cc1cc2ccc(F)cc2c(C2CCNCC2)c1C.O.O.O=S(=O)(Cl)c1ccccc1Cl.[Cl-].[Na+]>>COC(=O)Cc1cc2ccc(F)cc2c(C2CCN(S(=O)(=O)c3ccccc3Cl)CC2)c1C",
        "output": "99"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cl.NC(=O)[C@@H](N)CC1CC1.O=C(O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1>>NC(=O)[C@H](CC1CC1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1",
        "output": "738"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(CO[Si](C)(C)C(C)(C)C)n1cc(C(=O)c2cncc(N)c2)c2cncc(F)c21.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(C(C)C)C(C)C.O=C(O)Cn1ccc(C2CC2)n1>>CC(C)(CO[Si](C)(C)C(C)(C)C)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(C4CC4)n3)c2)c2cncc(F)c21",
        "output": "724"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C1COCCN1.CCN(CC)CC.CCOC(=O)c1cnc(Cl)cc1Oc1ccccc1>>CCOC(=O)c1cnc(N2CCOCC2)cc1Oc1ccccc1",
        "output": "220"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)O.CN1C(=O)C(F)(F)CN(C2CCCCC2)c2nc(Cl)ncc21.Cc1ccccc1S(=O)(=O)O.Nc1ccc(C(=O)NC2CCOCC2)cc1.O>>CN1C(=O)C(F)(F)CN(C2CCCCC2)c2nc(Nc3ccc(C(=O)NC4CCOCC4)cc3)ncc21",
        "output": "941"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)[C@H]1CC[C@H](c2ccc(OC)cc2)C1.II.O=S(=O)([O-])[O-].[Ag+2]>>COC(=O)[C@H]1CC[C@H](c2ccc(OC)c(I)c2)C1",
        "output": "372"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.CS(=O)(=O)c1ccc(Br)cc1[N+](=O)[O-].O.[Cl-].[NH4+].[Zn]>>CS(=O)(=O)c1ccc(Br)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CCNc1ccc(S(=O)(=O)N(C)CC(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>C#CCNc1ccc(S(=O)(=O)N(C)CC(=O)O)cc1",
        "output": "278"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1Cc2c(C(N)=O)c(-c3ccc(F)c(Cl)c3)nn2CC1C1CC1.ClCCl.O=C(O)C(F)(F)F>>NC(=O)c1c(-c2ccc(F)c(Cl)c2)nn2c1CNC(C1CC1)C2",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C(N(C)C)=[N+]1N=Nc2ncccc21.CN(C)C=O.CN1CCNCC1.Cl.F[P-](F)(F)(F)(F)F.NC(=O)c1sc(-n2cnc3ccc(C(=O)O)cc32)nc1-c1cccc(Cl)c1.O>>CN1CCN(C(=O)c2ccc3ncn(-c4nc(-c5cccc(Cl)c5)c(C(N)=O)s4)c3c2)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.CCOCCN.OCC1CO1>>CCOCCNCC(O)CO",
        "output": "16"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Nc1nc(C)c(-c2ccc(S(=O)(=O)Cl)s2)s1.CCN(CC)CC.CCN(CC)CCNC.ClCCl>>CCN(CC)CCN(C)S(=O)(=O)c1ccc(-c2sc(NC(C)=O)nc2C)s1",
        "output": "798"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)CC1.CCOC(=O)/N=N/C(=O)OCC.Cc1nc2ccccc2c(=O)n1-c1ccc(O)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1",
        "output": "846"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.O=Cc1ccc2cc[nH]c2c1>>O=Cc1ccc2ccn(Cc3ccccc3)c2c1",
        "output": "528"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C(=O)O)c1ccc(S(=O)(=O)/C=C/C#N)cc1.CCN=C=NCCCN(C)C.Cl.NCCO.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CC(C)(C(=O)NCCO)c1ccc(S(=O)(=O)/C=C/C#N)cc1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CN(C)CC(=O)N1CCc2ccc(N)cc21.ClC(Cl)Cl.O=C1CCC(=O)N1Cl>>CN(C)CC(=O)N1CCc2cc(Cl)c(N)cc21",
        "output": "121"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCC(=O)Cl.Cc1cccc(C(=O)c2[nH]c3cc(Cl)ccc3c2N)c1>>CCCCC(=O)Nc1c(C(=O)c2cccc(C)c2)[nH]c2cc(Cl)ccc12",
        "output": "422"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1ccc(C2=NN(C3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)C(=O)[C@H]3CCCC[C@@H]23)cc1OC.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)c1c[nH]c2c(-c3c(OCC4CC4)ccc4c3OCO4)ncnc12.O=C([O-])O.[Na+]>>COc1ccc(C2=NN(C3CCN(C(=O)[C@@H](Cc4ccccc4)NC(=O)c4c[nH]c5c(-c6c(OCC7CC7)ccc7c6OCO7)ncnc45)CC3)C(=O)[C@H]3CCCC[C@@H]23)cc1OC",
        "output": "989"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCn1c(=O)n(CCCCC(=O)O)c(=O)c2[nH]c(C(F)(F)F)nc21.CN(C)C=O.NC(=NO)c1ccc(F)cc1.O=C(n1ccnc1)n1ccnc1>>CCCCn1c(=O)n(CCCCc2nc(-c3ccc(F)cc3)no2)c(=O)c2[nH]c(C(F)(F)F)nc21",
        "output": "926"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](CN)C1.O=C(O)c1cc2cc(Cl)ccc2[nH]1>>CC(C)(C)OC(=O)N1CC[C@H](CNC(=O)c2cc3cc(Cl)ccc3[nH]2)C1",
        "output": "137"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CCCCCCN.Cc1cccc(C)c1Cl.Cc1ccccc1.[Na+].[Pd+2]>>CCCCCCNc1c(C)cccc1C",
        "output": "304"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CN1CCC(c2c[nH]c3ccc(OS(=O)(=O)c4ccc([N+](=O)[O-])cc4)cc23)CC1.[Pd]>>CN1CCC(c2c[nH]c3ccc(OS(=O)(=O)c4ccc(N)cc4)cc23)CC1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C(=O)Nc1ccc(C2CCNCC2)cc1.CC(C)C(=O)Nc1cccc(C2CCN(CCCc3c(-c4ccccc4)n(-c4ccccc4)c4ccccc34)CC2)c1.CC(C)C(=O)Nc1cccc(C2CCN(Cc3ccc(Oc4ccc(Cl)cc4)cc3)CC2)c1.CCn1c2ccccc2c2cc(C=O)ccc21>>CCn1c2ccccc2c2cc(CN3CCC(c4ccc(NC(=O)C(C)C)cc4)CC3)ccc21",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)OC(C)C.CC(C)(C)[O-].CC(C)(N)CO.O.O=[N+]([O-])c1ccc(F)cc1.[K+]>>CC(C)(N)COc1ccc([N+](=O)[O-])cc1",
        "output": "485"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)N1CCNCC1.CC(=O)N1N=C(c2cc(Br)ccc2F)C[C@@]1(CCC=O)c1ccccc1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.[Na+]>>CC(=O)N1CCN(CCC[C@@]2(c3ccccc3)CC(c3cc(Br)ccc3F)=NN2C(C)=O)CC1",
        "output": "484"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COC(C)C(C)n1c(C)c(C(=O)O)c2cccnc21.COc1cc(C)[nH]c(=O)c1CN.Cl.F[P-](F)(F)(F)(F)F.O.[Cl-].[Na+]>>COc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n(C(C)C(C)OC)c2ncccc12",
        "output": "674"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1nc2ccccc2cc1NC(=O)Oc1ccccc1.Clc1ccccc1N1CCNCC1>>Cc1nc2ccccc2cc1NC(=O)N1CCN(c2ccccc2Cl)CC1",
        "output": "525"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Br.C=C.CCC(=O)CC.CCN(CC)CC.CCN(CC)CC.COc1ccc2cc(Br)ccc2c1.Cl[Pd]Cl.[Na+].[OH-]>>C=Cc1ccc2cc(OC)ccc2c1",
        "output": "539"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](OC(CC)C(C)(C)O)CC2)c2ncnn12.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n([C@@H]2CC[C@@H](OC(CC)C(C)(C)O)CC2)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOc1ccccc1Br.Cl.ClCCl.O=C1CCC(=O)O1.[Al+3].[Cl-].[Cl-].[Cl-]>>CCOc1ccc(C(=O)CCC(=O)O)cc1Br",
        "output": "345"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(C[C@@H]2NCCc3cc(OC)c(OC)cc32)cc1OC.NC1CCCc2ccccc21.O=C(Br)CBr>>COc1ccc(C[C@H]2c3cc(OC)c(OC)cc3CCN2CC(=O)NC2CCCc3ccccc32)cc1OC",
        "output": "946"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2sc3cnccc3c2C)C2CCCCC2)cc1.[Na+].[OH-]>>Cc1c(C(Nc2ccc(C(=O)N(C)CCC(=O)O)cc2)C2CCCCC2)sc2cnccc12",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.CS(C)=O.Cn1c(Oc2ccc(Br)cc2)nc2cccnc21.[K+]>>Cn1c(Oc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)nc2cccnc21",
        "output": "942"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc2c(c1)C(=O)CCC2>>CC(C)(C)OC(=O)Nc1ccc2c(c1)C(=O)CCC2",
        "output": "735"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1c2cc(Cl)nc(=O)n2CCC1(C)C.OCc1cc(F)c(F)c(F)c1>>CN1c2cc(OCc3cc(F)c(F)c(F)c3)nc(=O)n2CCC1(C)C",
        "output": "653"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.N#Cc1cccc(CBr)c1.OCCO.[H-].[Na+]>>N#Cc1cccc(COCCO)c1",
        "output": "464"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CON=C(C(=O)N[C@@H]1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(COC(N)=O)CS[C@H]12)c1ccco1.COc1ccccc1.O=C(O)C(F)(F)F>>CON=C(C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(COC(N)=O)CS[C@H]12)c1ccco1",
        "output": "228"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.N#Cc1cccc(F)c1>>N#Cc1cccc(N2CCCCC2)c1",
        "output": "26"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.N#C[Cu].O.O=[N+]([O-])c1cc(S(F)(F)(F)(F)F)ccc1Br>>N#Cc1ccc(S(F)(F)(F)(F)F)cc1[N+](=O)[O-]",
        "output": "531"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.Cc1cccc(Br)c1O.OCC[C@H]1CN(Cc2ccccc2)CCN1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cccc(Br)c1OCC[C@H]1CN(Cc2ccccc2)CCN1",
        "output": "478"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCOCC.Cl.Fc1ccc2cccc(N3CCNCC3)c2c1.O.O=C(O)C(F)(F)F.O=C([O-])[O-].O=C1NCCc2ccc(OCCCCCl)cc2N1.[I-].[K+].[Na+].[Na+]>>O=C1NCCc2ccc(OCCCCN3CCN(c4cccc5ccc(F)cc45)CC3)cc2N1",
        "output": "138"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COc1ccc(-n2ccn(-c3ccc(Oc4ccccc4)cc3)c2=O)cc1.ClCCl.O=C([O-])O.[Na+]>>O=c1n(-c2ccc(O)cc2)ccn1-c1ccc(Oc2ccccc2)cc1",
        "output": "402"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Cl.FC1(F)CNC1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=c1c(OCc2ccccc2)cn(-c2ccc(I)cc2F)nc1-c1ccnn1-c1ccccc1.[Na+].[Pd].[Pd]>>O=c1c(OCc2ccccc2)cn(-c2ccc(N3CC(F)(F)C3)cc2F)nc1-c1ccnn1-c1ccccc1",
        "output": "931"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Oc1ccc(O)cc1.CCOC(C)=O.CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1cc(CBr)cc([N+](=O)[O-])c1.[I-].[K+].[K+].[K+]>>CC(C)(C)[Si](C)(C)Oc1ccc(OCc2cc([N+](=O)[O-])cc([N+](=O)[O-])c2)cc1",
        "output": "127"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.Nn1c(N2CCCC2)nc2cc(F)ccc2c1=O.O=C(Cl)C(=O)Cl.O=C(O)CCc1cccc(F)c1.c1ccncc1>>O=C(CCc1cccc(F)c1)Nn1c(N2CCCC2)nc2cc(F)ccc2c1=O",
        "output": "459"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCC.CCN(CC)CC.CCOC(=O)C(C)C(C)N.CCOC(C)=O.ClCCl.O=C(Cl)c1ccccc1>>CCOC(=O)C(C)C(C)NC(=O)c1ccccc1",
        "output": "271"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.NCC12CCCN1CCC2.O=C(O)c1cn2ccccc2n1.O=C(n1ccnc1)n1ccnc1>>O=C(NCC12CCCN1CCC2)c1cn2ccccc2n1",
        "output": "697"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cl.FC(F)(F)OCCBr.O=C(Nc1c2c(nn1-c1ccccc1)CCC2)N[C@@H]1CNC[C@H]1c1ccccc1>>O=C(Nc1c2c(nn1-c1ccccc1)CCC2)N[C@@H]1CN(CCOC(F)(F)F)C[C@H]1c1ccccc1",
        "output": "73"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCN(C(C)C)C(C)C.Cc1ccc(N2CCc3ncnc(Cl)c3C2)c(C#N)c1.Cl.NCc1ccc2ccccc2n1>>Cc1ccc(N2CCc3ncnc(NCc4ccc5ccccc5n4)c3C2)c(C#N)c1",
        "output": "110"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1cccc(CC(C)C(C(=O)O)c2ccccc2)c1.Cl.ClCCl.O=C(Cl)C(=O)Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc2c(c1)CC(C)C(c1ccccc1)C2=O",
        "output": "274"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)CN(CC(=O)OC(C)(C)C)C(CCCCNC(=O)CN(CC(=O)NCCCCC(C(=O)OC(C)(C)C)N(CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C)C(CCCCNC(=O)OCc1ccccc1)C(=O)NCCCCC(C(=O)OC(C)(C)C)N(CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C.CO.[Pd]>>CC(C)(C)OC(=O)CN(CC(=O)OC(C)(C)C)C(CCCCNC(=O)CN(CC(=O)NCCCCC(C(=O)OC(C)(C)C)N(CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C)C(CCCCN)C(=O)NCCCCC(C(=O)OC(C)(C)C)N(CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C)C(=O)OC(C)(C)C",
        "output": "574"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCOC(C)=O.OCC(CO)(CO)CO.c1ccncc1>>CC(C)(C)[Si](OCC(CO)(CO)CO)(c1ccccc1)c1ccccc1",
        "output": "602"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCNC.O=C(O)Cc1ccc(-n2nc(C(F)(F)F)c3c2CCCC3)cc1>>CCCN(C)C(=O)Cc1ccc(-n2nc(C(F)(F)F)c3c2CCCC3)cc1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(Cl)c2ccccc12.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].OB(O)c1ccc(CCOC2CCCCO2)cc1.[Na+].[Na+].[Pd].[Pd]>>C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(CCOC3CCCCO3)cc2)c2ccccc12",
        "output": "866"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Cc1c(C(=O)O)c2ccccc2n1C.ClCCl.N[C@@H]1CN2CCC1CC2.O=C(Cl)C(=O)Cl>>Cc1c(C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc2n1C",
        "output": "674"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COc1ccc(F)cc1C=O.[BH4-].[Na+]>>COc1ccc(F)cc1CO",
        "output": "356"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.Cc1nc(C(=O)Nc2cc(Br)cc3[nH]ncc23)cs1.Cl[Pd]Cl.N#Cc1cccc(B(O)O)c1.O=C([O-])[O-].[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1nc(C(=O)Nc2cc(-c3cccc(C#N)c3)cc3[nH]ncc23)cs1",
        "output": "909"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.O.c1ccc2c3c([nH]c2c1)CCNCC3>>CC(C)(C)OC(=O)N1CCc2[nH]c3ccccc3c2CC1",
        "output": "694"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCCOc1cnc(-c2ccc(O)cc2)nc1.FC(F)(COCCCCBr)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)F.O>>CCCCCCOc1cnc(-c2ccc(OCCCCOCC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)F)cc2)nc1",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C#N)c1cccc(Cl)c1.O.[Al+3].[Al+3].[Cl-].[Cl-].[Cl-].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC(CN)c1cccc(Cl)c1",
        "output": "246"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C(=O)O)c1ccc([N+](=O)[O-])c(Cl)c1.CC(C)CNCC(C)C.CCN(C(C)C)C(C)C.ClCCl.O=S(Cl)Cl>>CC(C)CN(CC(C)C)C(=O)C(C)(C)c1ccc([N+](=O)[O-])c(Cl)c1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.N#Cc1ccc(Cl)c([N+](=O)[O-])c1.Nc1cccc(Br)c1.O>>N#Cc1ccc(Nc2cccc(Br)c2)c([N+](=O)[O-])c1",
        "output": "510"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C[C@@H]1NCC[C@]1(C)O.N#Cc1ccc(F)c(C(F)(F)F)c1.O=C([O-])[O-].[Li+].[Li+]>>C[C@@H]1N(c2ccc(C#N)cc2C(F)(F)F)CC[C@]1(C)O",
        "output": "26"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCN(CC)CC.CCOC(=O)[C@@H]1CC2(CC[C@@H]1N)OCCO2.CCOC(C)=O.CSCC[C@H](NC(=O)OCc1ccccc1)C(=O)O.Cc1ccc(S(=O)(=O)O)cc1.O.On1nnc2ccccc21>>CCOC(=O)[C@@H]1CC2(CC[C@@H]1NC(=O)[C@H](CCSC)NC(=O)OCc1ccccc1)OCCO2",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(C(C)C)C(C)C.ClCCl.O=C(O)CCc1c[nH]c2c1C(=O)CCC2.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCN(C(=O)CCc2c[nH]c3c2C(=O)CCC3)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.C[Si](C)(C)C=[N+]=[N-].O=C(O)C(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.c1ccccc1>>COC(=O)C(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)c1nc(-c2cc(Cl)c(C3CC3)cn2)no1.OCc1ccccn1>>CC(C)(C)c1nc(-c2cc(OCc3ccccn3)c(C3CC3)cn2)no1",
        "output": "651"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NC1CCC(=O)CC1.O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1>>CC(C)(C)OC(=O)NC1CCC(N2CC(NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1",
        "output": "187"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)COc1cccc2c1c1c(C(N)=O)cccc1n2Cc1cccc(Cl)c1.O=C(O)C(F)(F)F>>NC(=O)c1cccc2c1c1c(OCC(=O)O)cccc1n2Cc1cccc(Cl)c1",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Cl.CC1(C)Oc2cc3nonc3cc2C(N)C1O.CCN(CC)CC.ClCCl>>CC(=O)NC1c2cc3nonc3cc2OC(C)(C)C1O",
        "output": "206"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.ClCCl.O=C(O)CCCc1coc2ccccc12.OCCc1csc2ccccc12.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCCc1coc2ccccc12",
        "output": "231"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC#N.CC(=O)Cl.CC(=O)OC(C)=O.Cc1nc(NC(=O)N[C@H](C)c2ccccc2)cc2[nH]nc(N)c12.ClCCl.O.[Na+].[OH-].c1ccncc1>>CC(=O)Nc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)nc(C)c12",
        "output": "527"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)C(Cc1ccc(OCCc2csc(-c3ccc(C(C)C)cc3)n2)cc1C)OCC.[Li+].[OH-]>>CCOC(Cc1ccc(OCCc2csc(-c3ccc(C(C)C)cc3)n2)cc1C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1O.[K+].[K+].[Na+].[OH-]>>COc1cc(F)ccc1[N+](=O)[O-]",
        "output": "62"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.COC(=O)COc1ccc(OC/C=C/C#Cc2ccc(C#C/C=C/COc3ccc(OCC(=O)OC)c(C)c3)cc2)cc1C.Cl.O.[Na+].[OH-]>>COC(=O)COc1ccc(OC/C=C/C#Cc2ccc(C#C/C=C/COc3ccc(OCC(=O)O)c(C)c3)cc2)cc1C",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC[S-].CN(C)C=O.COc1ccc2c(c1)CN(C)CC2c1ccc2sccc2c1.[Cl-].[NH4+].[Na+]>>CN1Cc2cc(O)ccc2C(c2ccc3sccc3c2)C1",
        "output": "732"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)c1cc(Br)c(COC(=O)[O-])cc1[N+](=O)[O-].CC(C)(C)c1cc2c(cc1N)OC(=O)C2(C)C.CC1CCCO1.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.O.O=C(O)c1c[nH]c2ccccc2c1=O.c1ccncc1>>CC(C)(C)c1cc2c(cc1NC(=O)c1c[nH]c3ccccc3c1=O)OC(=O)C2(C)C",
        "output": "739"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.Clc1ccc(OC2CCNCC2)nc1.O=c1[nH]nc(CS(=O)(=O)Cl)[nH]1>>O=c1[nH]nc(CS(=O)(=O)N2CCC(Oc3ccc(Cl)cn3)CC2)[nH]1",
        "output": "584"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.CN1CCC(CO)CC1.Fc1ccc(I)cc1.[H-].[Na+]>>CN1CCC(COc2ccc(I)cc2)CC1",
        "output": "485"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOCc1nc2c(Cl)nc3ccccc3c2n1CC1CC(c2ccccc2)N(C)O1.CO.N>>CCOCc1nc2c(N)nc3ccccc3c2n1CC1CC(c2ccccc2)N(C)O1",
        "output": "682"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "F[C@@H]1CNC[C@@H]1CNC1CC1.O=C(O)c1cn([C@@H]2C[C@@H]2F)c2nc(Cl)c(F)cc2c1=O>>O=C(O)c1cn([C@@H]2C[C@@H]2F)c2nc(N3C[C@@H](F)[C@@H](CNC4CC4)C3)c(F)cc2c1=O",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCC(O)CCCC(Cc1ccc(C=CC(=O)O)cc1)C(C)=O.CCO.[H][H].[Pd]>>CCCCCC(O)CCCC(Cc1ccc(CCC(=O)O)cc1)C(C)=O",
        "output": "344"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Cn1c(=O)ccc2cc(OCCCN3C(=O)c4ccccc4C3=O)ccc21.NN.O>>Cn1c(=O)ccc2cc(OCCCN)ccc21",
        "output": "242"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.Cc1ccc(Br)c(F)c1.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1ccc(B2OC(C)(C)C(C)(C)O2)c(F)c1",
        "output": "942"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCc2[nH]c(-c3ccnc(Cl)c3)cc2C1=O.CI.CN(C)C=O.O.O=C([O-])[O-].[Cs+].[Cs+]>>Cn1c(-c2ccnc(Cl)c2)cc2c1CCN(C(=O)OC(C)(C)C)C2=O",
        "output": "191"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN.COC[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1ccc(Cl)nc1)C2>>CNc1ccc(S(=O)(=O)N2CCC3=Cc4c(cnn4-c4ccc(F)cc4)C[C@]3(COC)C2)cn1",
        "output": "70"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OCCn1ccc(=O)c(O)c1Cc1ccc(F)cc1.CO.N>>O=c1ccn(CCO)c(Cc2ccc(F)cc2)c1O",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)N1CC2(CCNCC2)c2ccccc21.Cl.ClC(Cl)Cl.O=C(NC1CCN(c2ccccc2)CC1)Oc1ccccc1.O=C([O-])O.[Na+]>>CS(=O)(=O)N1CC2(CCN(C(=O)NC3CCN(c4ccccc4)CC3)CC2)c2ccccc21",
        "output": "525"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COC(=O)CCc1ccc(OCc2ccc(Cn3c(-c4ccccc4)cc4ccccc43)cc2)cc1.[Na+].[OH-]>>O=C(O)CCc1ccc(OCc2ccc(Cn3c(-c4ccccc4)cc4ccccc43)cc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)C(c1ccc(Cn2[nH]c3ccccc3c2=O)cc1)C1CCCC1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)C(c1ccc(Cn2[nH]c3ccccc3c2=O)cc1)C1CCCC1",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1cc2c(s1)CCN(C(=O)OC(C)(C)C)C2.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1cc2c(s1)CCNC2",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(C)=O.ClCCCBr.O=C([O-])[O-].O=c1cc(-c2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)oc2cc(O)ccc12.[K+].[K+]>>O=c1cc(-c2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)oc2cc(OCCCCl)ccc12",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CC(Cl)Cl.CN(C)C=O.COc1ccc(F)c(C(=O)c2cc(Cl)ccc2-n2cccc2)c1OC.O=P(Cl)(Cl)Cl.[Na+]>>COc1ccc(F)c(C(=O)c2cc(Cl)ccc2-n2cccc2C=O)c1OC",
        "output": "641"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCC12CCC(C(=O)O)(CC1)CC2.ClCCl.O=C(Cl)C(=O)Cl>>CCCCCC12CCC(C(=O)Cl)(CC1)CC2",
        "output": "56"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)CCN(Cc1ccc(Oc2ccc(C(=O)O)cn2)cc1)C(=O)OC(C)(C)C.CCN(C(C)C)C(C)C.CN.Cl.ClCCCl.ClCCl.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CNC(=O)c1ccc(Oc2ccc(CN(CCC(C)C)C(=O)OC(C)(C)C)cc2)nc1",
        "output": "674"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(=O)Cl.Cc1[nH]c2c(-c3cc(C(F)F)ccc3OCC3CC3)ncnc2c1C(=O)N[C@@H]1CN[C@@H](C)C1.Cl>>CCC(=O)N1C[C@@H](NC(=O)c2c(C)[nH]c3c(-c4cc(C(F)F)ccc4OCC4CC4)ncnc23)C[C@@H]1C",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCc1cccc(Br)c1.CC#N.O=C([O-])[O-].[K+].[K+].c1ccc(C2CNCCO2)cc1>>Brc1cccc(CN2CCOC(c3ccccc3)C2)c1",
        "output": "248"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccccc1-c1nc(C)c(Cl)c(=O)n1CCc1ccccc1.ClCCl>>Cc1nc(-c2ccccc2O)n(CCc2ccccc2)c(=O)c1Cl",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)c1ccc(-c2ccc([N+](=O)[O-])cc2)cc1Cl.Cl.[Fe]>>COC(=O)c1ccc(-c2ccc(N)cc2)cc1Cl",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC(C)(C)OC(=O)NC(C)(C)C(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.Cl.Cl.Cl.NCCn1ccc2ncnc(Nc3ccc(Oc4cccc5sncc45)c(Cl)c3)c21.O.On1nnc2ccccc21>>CC(C)(C)OC(=O)NC(C)(C)C(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc5sncc45)c(Cl)c3)c21",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(N)CCCC1NC(=O)c1ccccc1-n1nccn1.CCN(C(C)C)C(C)C.CS(C)=O.Cl.FC(F)(F)c1cnc(Cl)cn1>>CC1(Nc2cnc(C(F)(F)F)cn2)CCCC1NC(=O)c1ccccc1-n1nccn1",
        "output": "148"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.C1COCCO1.CC(C)(C)OC(=O)N1CCc2[nH]nc(CO)c2C1.Cl>>OCc1n[nH]c2c1CNCC2",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1cc(NC(=O)C(F)(F)F)cc2ccoc12.O.O=C([O-])[O-].[K+].[K+]>>Cc1cc(N)cc2ccoc12",
        "output": "491"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCN1CCCCC1.O=c1c(Cc2ccccc2)cn2c3c(cc(O)cc13)Sc1ccc(Br)cc1-2>>O=c1c(Cc2ccccc2)cn2c3c(cc(OCCN4CCCCC4)cc13)Sc1ccc(Br)cc1-2",
        "output": "74"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cn1nccc1-c1cc(-c2ccccc2)ccc1O.N#Cc1cc(S(=O)(=O)Nc2ncc(F)s2)ccc1F.O=C([O-])[O-].[Cl-].[K+].[K+].[NH4+]>>Cn1nccc1-c1cc(-c2ccccc2)ccc1Oc1ccc(S(=O)(=O)Nc2ncc(F)s2)cc1C#N",
        "output": "564"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1cc2c(O[Si](C)(C)C(C)(C)C)cccc2o1.[F-]>>Cc1cc2c(O)cccc2o1",
        "output": "754"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)[C@@H](NCc1cccc2ccccc12)C(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1ccccc1=O)=[N+](C)C.CN(C)C=O.COc1ccc(CNC(=O)[C@@H](N)C(C)C)c(O)c1.F[B-](F)(F)F>>COc1ccc(CNC(=O)[C@@H](NC(=O)[C@H](NCc2cccc3ccccc23)[C@H](O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C(C)C)c(O)c1",
        "output": "133"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COCC1COc2cc3ncnc(Cl)c3cc2O1.Cc1ccc(N)cc1Cl>>COCC1COc2cc3ncnc(Nc4ccc(C)c(Cl)c4)c3cc2O1",
        "output": "352"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.CCOCCO.CN(C)C(=O)/N=N/C(=O)N(C)C.O.O=C(NCCCCN1CCC(c2ccc3c(c2O)CCCC3)CC1)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1>>CCOCCOc1c(C2CCN(CCCCNC(=O)c3ccc(-c4ccc(C(F)(F)F)cc4)cc3)CC2)ccc2c1CCCC2",
        "output": "550"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(=O)C(CC(C)C)c1cc(-c2ccc(C(F)(F)F)cc2)cc(C2CCCN(Cc3ccc(OC(F)(F)F)cc3)C2)c1.[K+].[OH-]>>CC(C)CC(C(=O)O)c1cc(-c2ccc(C(F)(F)F)cc2)cc(C2CCCN(Cc3ccc(OC(F)(F)F)cc3)C2)c1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)C1Cc2cc3ccccc3n2C1.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[Li+].[NH4+]>>OCC1Cc2cc3ccccc3n2C1",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.COCCOCCOC.Cc1cc(NCCOCc2ccccc2)c([N+](=O)[O-])c(Cl)n1.O.Oc1ccccc1.[H-].[Na+]>>Cc1cc(NCCOCc2ccccc2)c([N+](=O)[O-])c(Oc2ccccc2)n1",
        "output": "516"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC1CO1.CCOCC.Cc1ccc2cc[nH]c2c1.O.[H-].[Na+]>>Cc1ccc2ccn(CC(C)O)c2c1",
        "output": "749"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC2=NCCCN2CC1.C1CCOC1.C=C[C@@H]1C[C@]1(NC(=O)OC(C)(C)C)C(=O)O.CCOC(C)=O.Nc1ccccc1S(N)(=O)=O.O=C(n1ccnc1)n1ccnc1>>C=C[C@@H]1C[C@]1(NC(=O)OC(C)(C)C)C(=O)NS(=O)(=O)c1ccccc1N",
        "output": "801"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COC(=O)c1ccc2c(=O)[nH]c(Cc3cccc(Cl)c3)nc2c1.Cl.O.[Na+].[OH-]>>O=C(O)c1ccc2c(=O)[nH]c(Cc3cccc(Cl)c3)nc2c1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N(C)C.CC(C)(C)OC(=O)C(C)(C)O/N=C(\\C(=O)O)c1nsc(N)n1.CCN(CC)CC.CCOC(C)=O.COc1ccc(COC(=O)C2=C(CCl)CS[C@@H]3[C@H](N)C(=O)N23)cc1.CS(=O)(=O)Cl.Cl.O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(COC(=O)C2=C(CCl)CS[C@@H]3[C@H](NC(=O)/C(=N\\OC(C)(C)C(=O)OC(C)(C)C)c4nsc(N)n4)C(=O)N23)cc1",
        "output": "587"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)c1ccc(OCc2ccccc2)c(N(Cc2ccccc2)S(C)(=O)=O)c1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.[Br-].[Br-].[Br-]>>CS(=O)(=O)N(Cc1ccccc1)c1cc(C(=O)CBr)ccc1OCc1ccccc1",
        "output": "360"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COCCl.COc1cc(Cl)ccc1-c1cscc1-c1ccc(O)cc1.[H-].[Na+]>>COCOc1ccc(-c2cscc2-c2ccc(Cl)cc2OC)cc1",
        "output": "375"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "FC(F)Oc1ccc(N2CCN[C@@H](Cc3ccccc3)C2)cc1OC1CCC1.O=C(O)Cc1c[nH]cn1>>O=C(Cc1c[nH]cn1)N1CCN(c2ccc(OC(F)F)c(OC3CCC3)c2)C[C@@H]1Cc1ccccc1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)C1CCN(c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cccc(F)c23)CC1O.CO.Cl.[Li+].[OH-]>>O=C(O)C1CCN(c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cccc(F)c23)CC1O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCN1.CCCCCCC/C=C/C(=O)O>>CCCCCCC/C=C/C(=O)N1CCOCC1",
        "output": "870"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCCCC1CN.CCN(C(C)C)C(C)C.COc1ccccc1S(=O)(=O)Cl.ClCCl>>COc1ccccc1S(=O)(=O)NCC1CCCCN1C(=O)OC(C)(C)C",
        "output": "43"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCc1ccccc1.CCN(C(C)C)C(C)C.CCOC(C)=O.COc1ncccc1-c1[nH]c2ccccc2c1C1CCNCC1.ClCCl.O>>COc1ncccc1-c1[nH]c2ccccc2c1C1CCN(Cc2ccccc2)CC1",
        "output": "248"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(O[Si](C)(C)C(C)(C)C)n1c(C(=O)N2CCN(c3cccc(CO)c3)CC2)ccc1-c1ccccc1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.[F-]>>CC(O)n1c(C(=O)N2CCN(c3cccc(CO)c3)CC2)ccc1-c1ccccc1",
        "output": "708"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOCC.COC(=O)C1CCc2cc(C(=O)c3ccc(C)cc3)c(O)cc21>>Cc1ccc(C(=O)c2cc3c(cc2O)C(C(=O)O)CC3)cc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cnn(-c2cc3c(c(C4CC4)n2)CN(c2cc4c(cc2C)CCC(c2ncccc2F)O4)C(=O)N3)c1.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>Cc1cc2c(cc1N1Cc3c(cc(-n4cc(CO)cn4)nc3C3CC3)NC1=O)OC(c1ncccc1F)CC2",
        "output": "471"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOP(=O)(C#N)OCC.CCOP(=O)(CCN)OCC.CN(C)C=O.CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)O)cc1.CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)O)cc1.Cl.O.O.O.O.O=C(O)C(=O)O>>CCOP(=O)(CCNC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)OCC",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.O=C(O)C1Cc2ccccc2C1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCC1Cc2ccccc2C1",
        "output": "231"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN1CCOCC1.COC(=O)[C@H](N)CC1CCCCC1.Cl.ClCCl.F[B-](F)(F)F>>COC(=O)[C@@H](CC1CCCCC1)NC(=O)CNC(=O)OC(C)(C)C",
        "output": "129"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC1c2c(ccc3cnn(C[C@H](C)NC(=O)OCc4ccccc4)c23)OCC1O.O=C(O)C(F)(F)F>>COC1c2c(ccc3cnn(C[C@H](C)N)c23)OCC1O",
        "output": "574"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cc(-c2nc(-c3ccc(Cn4cccc4)cc3)no2)cn1Cc1ccc(Cl)nc1.NCCN1CCCC1>>Cc1cc(-c2nc(-c3ccc(Cn4cccc4)cc3)no2)cn1Cc1ccc(NCCN2CCCC2)nc1",
        "output": "70"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN.Cc1ccc(F)cc1N=C=S>>CCNC(=S)Nc1cc(F)ccc1C",
        "output": "113"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C(=O)Cl)c1ccc2c(c1)CCc1ccccc1C2=O.CN1CCNCC1>>CC(C(=O)N1CCN(C)CC1)c1ccc2c(c1)CCc1ccccc1C2=O",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCC1CCC1.O=C1c2ccccc2C(=O)N1CCCc1cccc(O)c1>>O=C1c2ccccc2C(=O)N1CCCc1cccc(OCC2CCC2)c1",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1ccc(Br)cc1.C[C@H]1CNC[C@@H](C)N1.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>C[C@H]1CN(c2ccc(C(C)(C)C)cc2)C[C@@H](C)N1",
        "output": "294"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#CC(C)(O)c1nc(C)no1.C1CCNCC1.Nc1ncc(Cl)c(N2CCc3ccc(I)cc32)n1.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Cc1noc(C(C)(O)C#Cc2ccc3c(c2)N(c2nc(N)ncc2Cl)CC3)n1",
        "output": "664"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNC1.CN(C)C=O.NC(=O)CBr.O.[H-].[Na+]>>NC(=O)CN1CCCC1",
        "output": "443"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[O-].CCCO.COc1ccc(CO)cc1O.ClCc1ccccc1.[K+]>>COc1ccc(CO)cc1OCc1ccccc1",
        "output": "49"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)c1ccncc1.Nc1cc(Cl)cnc1C(=O)c1ccccc1.O=S(=O)(Cl)c1ccc(Cl)c(C(F)(F)F)c1.c1ccncc1>>O=C(c1ccccc1)c1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1",
        "output": "554"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CNc1ccnc(N)c1.COc1ccc(C(=O)CBr)cc1F.Cc1ccc(-c2cn3ccc(N4CCC(CCF)CC4)cc3n2)cc1>>CNc1ccn2cc(-c3ccc(OC)c(F)c3)nc2c1",
        "output": "508"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)=CCC/C(C)=C/COc1ccc(C(=O)O)cc1.Nc1cccnc1.[H-].[Na+]>>CC(C)=CCC/C(C)=C/COc1ccc(C(=O)Nc2cccnc2)cc1",
        "output": "759"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCNC1CCc2cccc(OC)c2C1.CCN(CC)CC.CN(C)C=O.NC1CCCc2ccccc21.O=C1c2ccccc2S(=O)(=O)N1CCCCBr.[I-].[Na+]>>CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1CCc2cccc(OC)c2C1",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C1CNCCN1.Clc1ccc2nccn2n1>>CC(C)C1CN(c2ccc3nccn3n2)CCN1",
        "output": "406"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.NCCc1ccc(C(F)(F)F)cc1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(NCCc1ccc(C(F)(F)F)cc1)C(F)(F)F",
        "output": "316"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C1CCN(c2ccc3c(C(=O)NCCc4ccccc4F)c(Cl)ccc3n2)CC1.Cl>>O=C(NCCc1ccccc1F)c1c(Cl)ccc2nc(N3CCC(C(=O)O)CC3)ccc12",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1ccc(-c2c(F)cc(B(O)O)cc2F)cc1.CCc1ccc(Br)s1>>CCc1ccc(-c2c(F)cc(-c3ccc(CC)s3)cc2F)cc1",
        "output": "864"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.N.NC(=S)NC1CC1.O=C(O)c1ccc(C(=O)CBr)cc1.S=C=NC1CC1>>O=C(O)c1ccc(-c2csc(NC3CC3)n2)cc1",
        "output": "716"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NC(CCCCNS(=O)(=O)c1c(Cl)ccc(N)c1O)C(=O)O.NC(N)=O.O=C=Nc1cccc(Cl)c1Cl>>CC(C)(C)OC(=O)NC(CCCCNS(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2cccc(Cl)c2Cl)c1O)C(=O)O",
        "output": "473"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)NCCN.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.ClCCl.F[P-](F)(F)(F)(F)F.Nc1ncnc2c(C(=O)O)cc(-c3cccc(F)c3)cc12>>CC(=O)NCCNC(=O)c1cc(-c2cccc(F)c2)cc2c(N)ncnc12",
        "output": "674"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.Cc1ccc2cccc(O[C@H](C)CO[Si](C)(C)C(C)(C)C)c2n1.O.O=[Se]=O>>C[C@H](CO[Si](C)(C)C(C)(C)C)Oc1cccc2ccc(C=O)nc12",
        "output": "619"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N[C@H](C(=O)O)C1CCCCC1.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.F[P-](F)(F)(F)(F)F>>CNC(=O)[C@@H](NC(=O)OC(C)(C)C)C1CCCCC1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)COc1ccc(C(=O)CN2CCN(c3ccncc3)CC2)cc1OC.O>>COc1cc(C(=O)CN2CCN(c3ccncc3)CC2)ccc1OCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CI.CN(C)C=O.Nc1c(O)cccc1[N+](=O)[O-].[K+].[OH-]>>COc1cccc([N+](=O)[O-])c1N",
        "output": "62"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClB(Cl)Cl.ClCCl.N#Cc1nc(N2CCCCC2)c2c(n1)N(CCOCc1ccccc1)CCN2>>N#Cc1nc(N2CCCCC2)c2c(n1)N(CCO)CCN2",
        "output": "178"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc(CCl)cc1.O=C([O-])[O-].O=c1[nH]ncc(Br)c1Br.[Br-].[K+].[K+]>>COc1ccc(Cn2ncc(Br)c(Br)c2=O)cc1",
        "output": "842"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)c1ccc(OCc2ccccc2)cc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.C[N+](C)(C)c1ccccc1.[Br-].[Br-].[Br-]>>O=C(CBr)c1ccc(OCc2ccccc2)cc1",
        "output": "360"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "II.[K+].[OH-].c1ccc2[nH]ncc2c1>>Ic1n[nH]c2ccccc12",
        "output": "923"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)CCc1cccc(OCC=C(c2ccc(Br)cc2)c2ccc(Br)cc2)c1.O.[Na+].[OH-]>>O=C(O)CCc1cccc(OCC=C(c2ccc(Br)cc2)c2ccc(Br)cc2)c1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.O=C(O)c1ccc(OCCCCCCOc2cc(F)c(F)c(F)c2)cc1.O=S(Cl)Cl>>O=C(Cl)c1ccc(OCCCCCCOc2cc(F)c(F)c(F)c2)cc1",
        "output": "3"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1cc(C=O)ccc1OCc1ccccc1.ClC(Cl)Cl.ClCCCl.NCc1ccccc1.O=C([O-])O.[Na+].[Na+]>>COc1cc(CNCc2ccccc2)ccc1OCc1ccccc1",
        "output": "683"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cccc(O)c1I.ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>COc1cccc(OS(=O)(=O)C(F)(F)F)c1I",
        "output": "731"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.C[C@H]1C[C@@H](N)CN1C(=O)OC(C)(C)C.ClCCl.O=S(=O)(Cl)c1c(F)c(Br)cc(F)c1Br>>C[C@H]1C[C@@H](NS(=O)(=O)c2c(F)c(Br)cc(F)c2Br)CN1C(=O)OC(C)(C)C",
        "output": "43"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CC(N2CCOCC2)CCN1.COc1ccc(CN(Cc2ccc(OC)cc2)c2ncc(-c3nc(N4CCOCC4)nc4c3CCN4c3ccc(C(=O)O)cc3F)cn2)cc1>>COc1ccc(CN(Cc2ccc(OC)cc2)c2ncc(-c3nc(N4CCOCC4)nc4c3CCN4c3ccc(C(=O)N4CCC(N5CCOCC5)CC4)cc3F)cn2)cc1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)C1CNCCC1=O.Cl.O.O=C([O-])[O-].[Na+].[Na+]>>COC(=O)C1CN(C(=O)OC(C)(C)C)CCC1=O",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC(C(=O)OC)c1c(C)nc2sc(CC)c(C)c2c1-c1ccc(C)cc1.CCO.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc2sc(CC)c(C)c2c1-c1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)N(C)C.CC(C)(C)OC(=O)N1CCC(N)CC1.Cc1ncc(-c2nc(Cl)ncc2F)n1C(C)C>>Cc1ncc(-c2nc(NC3CCN(C(=O)OC(C)(C)C)CC3)ncc2F)n1C(C)C",
        "output": "544"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)[C@@H]1C[C@@]2(CN(c3ccccc3)C(=O)O2)CN1C(=O)[C@@H](NC(=O)CC1CCCCC1)C(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CC(C)(C)[C@H](NC(=O)CC1CCCCC1)C(=O)N1C[C@@]2(C[C@H]1C(=O)O)CN(c1ccccc1)C(=O)O2",
        "output": "278"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cl.O.O=C(NC[C@H]1CC[C@@H](NCc2ccccc2)CC1)OCc1ccccc1.[K+].[OH-]>>NC[C@@H]1CC[C@H](NCc2ccccc2)CC1",
        "output": "574"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cc1nc(Cl)ccc1C#N.O=C[O-].[NH4+].[Pd]>>Cc1ncccc1C#N",
        "output": "40"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc2c(cc1F)[nH]c(=O)n2C1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(C)=O.Cc1cc(Nc2cc(C)c(C#N)c(Cl)n2)n[nH]1.NCCOc1ccncc1.O.O=C([O-])O.[Na+]>>Cc1cc(Nc2cc(C)c(C#N)c(NCCOc3ccncc3)n2)n[nH]1",
        "output": "70"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.CNCCN(C)c1ccc(F)cc1F.Nc1nc(Cl)c2ccn(CCBr)c2n1.O=C([O-])[O-].[K+].[K+]>>CN(CCN(C)c1ccc(F)cc1F)CCn1ccc2c(Cl)nc(N)nc21",
        "output": "73"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)c1cccnc1N.CC(C)(C)C(=O)Cl.CC(C)(C)C(=O)OC1(C)OC(C(C)(C)C)=Nc2ncccc21.CCN(CC)CC.CN(C)c1ccncc1.Cc1ccccc1.Cl.O>>CC(=O)c1cccnc1NC(=O)C(C)(C)C",
        "output": "332"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@H]1COC[C@H]1N.CN1CCCC1=O.COc1cc(OC)c(Cl)c(-c2ccc3nc(Cl)ncc3c2)c1Cl.O=C([O-])O.[Na+]>>COc1cc(OC)c(Cl)c(-c2ccc3nc(N[C@@H]4COC[C@@H]4NC(=O)OC(C)(C)C)ncc3c2)c1Cl",
        "output": "544"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CN(C)C=O.Cl[Pd]Cl.O=C([O-])[O-].O=C1c2ccccc2C(=O)N1Cc1nc2c(F)cccc2cc1Br.OB(O)c1ccccc1.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=C1c2ccccc2C(=O)N1Cc1nc2c(F)cccc2cc1-c1ccccc1",
        "output": "833"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1N.Clc1ncc(Cl)c(-c2c[nH]c3ccccc23)n1>>COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(-c2c[nH]c3ccccc23)n1",
        "output": "808"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.CCCCc1cc2cc(OC)ccc2c(Oc2ccc(/C=C/C(=O)O)cc2)c1-c1ccccc1.ClCCl>>CCCCc1cc2cc(O)ccc2c(Oc2ccc(/C=C/C(=O)O)cc2)c1-c1ccccc1",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cc(Br)ccc1C(=O)c1cc(-n2cc(CCO)nn2)ccc1C.Cc1cc(Nc2ccc(F)cc2F)ccc1C(=O)c1cc(-n2cc(CCO)nn2)ccc1C.N#Cc1cccc(N)c1>>Cc1cc(Nc2cccc(C#N)c2)ccc1C(=O)c1cc(-n2cc(CCO)nn2)ccc1C",
        "output": "405"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(CNS(=O)(=O)C(C)C)c1ccc(-c2ccc(CCN)cc2)cc1.O=S(=O)(Cl)c1ccccc1F>>CC(CNS(=O)(=O)C(C)C)c1ccc(-c2ccc(CCNS(=O)(=O)c3ccccc3F)cc2)cc1",
        "output": "43"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCC2=NCCCN2CC1.CC#N.CCn1cc(C(=O)O)c(=O)c2cc(F)c(F)c(F)c21.CN1CCC2(CCNC2)C1.Cl.Cl>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCC4(CCN(C)C4)C3)c(F)c21",
        "output": "676"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)c1c(Cc2ccc(C(=O)O)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1.ClCCl.NCCO.On1nnc2ccccc21>>COC(=O)c1c(Cc2ccc(C(=O)NCCO)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.Cc1cc(O)ccc1Cc1cc([C@@H]2O[C@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)c(OCc2ccccc2)cc1C.O.O=C([O-])[O-].O=C1c2ccccc2C(=O)N1CCBr.[I-].[K+].[K+]>>Cc1cc(OCCN2C(=O)c3ccccc3C2=O)ccc1Cc1cc([C@@H]2O[C@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@H](OCc3ccccc3)[C@H]2OCc2ccccc2)c(OCc2ccccc2)cc1C",
        "output": "75"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC[C@@H]1COc1ccc(I)cc1.Cl.O=C([O-])[O-].Oc1ccc(-c2nccs2)cc1.[Cs+].[Cs+].[Cu]I>>CC(C)(C)OC(=O)N1CCC[C@@H]1COc1ccc(Oc2ccc(-c3nccs3)cc2)cc1",
        "output": "382"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)C1CC=C(F)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCC1CC=C(F)CC1",
        "output": "225"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cn1ncc2c(N)cccc21.Nc1cccc2[nH]ncc12.O=C=NCc1ccc(N2CCCCCC2)cc1>>Cn1ncc2c(NC(=O)NCc3ccc(N4CCCCCC4)cc3)cccc21",
        "output": "888"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrBr.CC(=O)CCCCn1cnc2c1c(=O)n(C)c(=O)n2C.CO.O.[Na]>>Cn1c(=O)c2c(ncn2CCCCC(=O)CBr)n(C)c1=O",
        "output": "173"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(O)CN.Clc1nc(Nc2ccccc2)nc(-c2ccccc2)n1>>CC(C)(O)CNc1nc(Nc2ccccc2)nc(-c2ccccc2)n1",
        "output": "578"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCO.CCOC(C)=O.COc1cc2c(cc1OC)-c1cc(Cl)nc(=O)n1CC2.Cc1cccc(C)c1N.c1ccccc1>>COc1cc2c(cc1OC)-c1cc(Nc3c(C)cccc3C)nc(=O)n1CC2",
        "output": "161"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1ccc([N+](=O)[O-])c(Cl)n1.Nc1ccccc1O>>COc1ccc([N+](=O)[O-])c(Nc2ccccc2O)n1",
        "output": "434"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccc([N+](=O)[O-])c(N(C)C(=O)OC(C)(C)C)c1.Cc1ccccc1.[H][H].[Pd]>>COc1ccc(N)c(N(C)C(=O)OC(C)(C)C)c1",
        "output": "202"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CN(C)C=O.CN(C)c1ccc(B(O)O)cc1.CS(=O)(=O)c1ccc(-c2nc(N)c(C(=O)O)nc2Cl)cc1.O.O=C(O)C(F)(F)F.O=C([O-])[O-].[Cs+].[Cs+]>>CN(C)c1ccc(-c2nc(C(=O)O)c(N)nc2-c2ccc(S(C)(=O)=O)cc2)cc1",
        "output": "875"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)[C@@H](CC(=O)N1CCSCC1)CC1CCCCC1.O=S([O-])OO.[K+]>>C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)[C@@H](CC(=O)N1CCS(=O)(=O)CC1)CC1CCCCC1",
        "output": "847"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1ccc(Cl)c([N+](=O)[O-])c1.CC(C)(C)OC(=O)NC1CCNCC1>>CC(=O)c1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)c([N+](=O)[O-])c1",
        "output": "105"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCCC(COc2cccc(OS(=O)(=O)c3ccccc3Cl)c2)C1.Cl>>O=S(=O)(Oc1cccc(OCC2CCCNC2)c1)c1ccccc1Cl",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(SCCCCOc2cc3c(cc2[N+](=O)[O-])NC(=O)OC3(C)C)cc1C.OO>>Cc1ccc(S(=O)CCCCOc2cc3c(cc2[N+](=O)[O-])NC(=O)OC3(C)C)cc1C",
        "output": "199"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc2c(cc1OC)C(Cc1ccc(F)cc1)NCC2.NC1CCCc2ccccc21.O=C(Br)CBr>>COc1cc2c(cc1OC)C(Cc1ccc(F)cc1)N(CC(=O)NC1CCCc3ccccc31)CC2",
        "output": "946"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1C(=O)CCC2(Cc3ccccc3)C(O)CCCC12.Cc1ccc(S(=O)(=O)O)cc1.O.O=C([O-])O.OCCO.[Na+].c1ccccc1>>CC1C2CCCC(O)C2(Cc2ccccc2)CCC12OCCO2",
        "output": "265"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1ccccc1Sc1ccc2c(c1)NC(=O)/C2=C1\\C=C(N2CCOCC2)C(C)(C)O1.O.[Na+].[OH-]>>CC1(C)O/C(=C2/C(=O)Nc3cc(Sc4ccccc4C(=O)O)ccc32)C=C1N1CCOCC1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)C(CC1CCC(=O)CC1)c1ccc(S(C)(=O)=O)c(Cl)c1.O.[Li+].[OH-]>>CS(=O)(=O)c1ccc(C(CC2CCC(=O)CC2)C(=O)O)cc1Cl",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)C(CC(C)C)c1ccc(OCC2CC2)c(-c2cccc(F)c2)c1.CO.O.O.[Li+].[OH-]>>CC(C)CC(C(=O)O)c1ccc(OCC2CC2)c(-c2cccc(F)c2)c1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.CN1CCCC1=O.COCCBr.Cc1ccccc1.Cc1nc2cc(O)ccc2cc1F.O.O=C([O-])[O-].[Cs+].[Cs+]>>COCCOc1ccc2cc(F)c(C)nc2c1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)C[AlH]CC(C)C.CCOC(=O)c1cn(C(C)C)nc1C(F)(F)F.Cc1ccccc1.Cl>>CC(C)n1cc(CO)c(C(F)(F)F)n1",
        "output": "471"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.Cc1c(N[C@@H](c2nnc(-c3ccc(C#N)cc3)o2)[C@H](C)O)ccc(C#N)c1Cl.ClCCl.c1ccncc1>>CC(=O)O[C@@H](C)[C@@H](Nc1ccc(C#N)c(Cl)c1C)c1nnc(-c2ccc(C#N)cc2)o1",
        "output": "126"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOP(=O)(OCC)c1ccc2cc(-c3cccs3)cc(-c3cccc4ccccc34)c2n1.C[Si](C)(C)Br.ClCCl>>O=P(O)(O)c1ccc2cc(-c3cccs3)cc(-c3cccc4ccccc34)c2n1",
        "output": "535"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCCCBr.CC#N.CC(=O)c1cc(Br)c(O)c(Br)c1>>CC(=O)c1cc(Br)c(OCCCBr)c(Br)c1",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C([O-])[O-].O=Cc1ccc(O)c(F)c1.[K+].[K+]>>O=Cc1ccc(OCc2ccccc2)c(F)c1",
        "output": "127"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.N#CCBr.O=C([O-])[O-].Oc1ccc(C(=C2CCCCCC2)c2ccc(O)cc2)cc1.[K+].[K+]>>N#CCOc1ccc(C(=C2CCCCCC2)c2ccc(O)cc2)cc1",
        "output": "802"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)CC1.CO.ClCCl.O=C(O)C(F)(F)F>>Fc1cccc(F)c1-c1ccc2cnc(Nc3cnccc3N3CCNCC3)n2n1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1ccc([N+](=O)[O-])c2c1CCCC2.CC(=O)Nc1cccc2c1CCCC2.CC(=O)Nc1ccccc1.Nc1cccc2c1CCCC2>>Nc1ccc([N+](=O)[O-])c2c1CCCC2",
        "output": "66"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN.O=CC1(c2cccc(C(F)(F)F)c2)CCCCC1>>CNCC1(c2cccc(C(F)(F)F)c2)CCCCC1",
        "output": "426"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(/C=C/c2nc(-c3ccc(Cl)cc3Cl)cn2CC(=O)O)cc1.NCCc1ccc(F)cc1>>COc1ccc(/C=C/c2nc(-c3ccc(Cl)cc3Cl)cn2CC(=O)NCCc2ccc(F)cc2)cc1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.CCO.Cc1ccc(-c2c3ccccc3cc3ccccc23)c2ccccc12.ClCCl.O.O=S([O-])[O-].[Na+].[Na+]>>Cc1ccc(-c2c3ccccc3c(Br)c3ccccc23)c2ccccc12",
        "output": "98"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCCBr.C1CCOC1.CCCCCCCCCCCCCCOc1ccc(Br)cc1.COB(OC)OC.Cl.[Mg]>>CCCCCCCCCCCCCCOc1ccc(B(O)O)cc1",
        "output": "789"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1ccc(C(CC2CCOCC2)c2ccc(S(=O)(=O)C3CC3)cc2)[nH]1.[Na+].[OH-]>>O=C(O)c1ccc(C(CC2CCOCC2)c2ccc(S(=O)(=O)C3CC3)cc2)[nH]1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(N2CCC(N3CCCC3C)C2)ccc1N.O=C(O)c1ccc(-c2cc[nH]n2)cc1>>Cc1cc(N2CCC(N3CCCC3C)C2)ccc1NC(=O)c1ccc(-c2cc[nH]n2)cc1",
        "output": "50"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCO.CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)[O-])[C@H]21.O.[Na+].[Na+].[OH-]>>CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O)[C@H]21",
        "output": "151"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Nc1cccc(-c2nnn[nH]2)c1.O=S(=O)(Cl)c1ccc(-c2ccno2)s1>>O=S(=O)(Nc1cccc(-c2nnn[nH]2)c1)c1ccc(-c2ccno2)s1",
        "output": "861"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CS(=O)(=O)Nc1ccc(C(C#N)c2ccc(Cl)cc2)cc1C(=O)O.ClCCl.F[P-](F)(F)(F)(F)F.Nc1cc(Cl)c(Cl)c(Cl)c1.O.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CS(=O)(=O)Nc1ccc(C(C#N)c2ccc(Cl)cc2)cc1C(=O)Nc1cc(Cl)c(Cl)c(Cl)c1",
        "output": "50"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CC(=O)O.Nc1ccc(-c2ccccc2C(F)(F)F)cc1[N+](=O)[O-]>>Nc1c(Br)cc(-c2ccccc2C(F)(F)F)cc1[N+](=O)[O-]",
        "output": "98"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)OC)CC2.CCOC(C)=O.CO>>CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)NC1C2CC3CC(C2)CC1C3.Cn1ncc(C(=O)O)c1-c1ccccc1>>CC(C)N(C(=O)c1cnn(C)c1-c1ccccc1)C1C2CC3CC(C2)CC1C3",
        "output": "733"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)O.CNc1c(Br)cc(C(F)(F)F)cc1[N+](=O)[O-].O.[Fe]>>CNc1c(N)cc(C(F)(F)F)cc1Br",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#Cc1ccc(C(N)=O)cc1[N+](=O)[O-].C1CCOC1.[Cl-].[Fe].[NH4+]>>C#Cc1ccc(C(N)=O)cc1N",
        "output": "489"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=[N+]([O-])c1ccc(CCNCc2ccccc2)cc1.[Pd]>>Nc1ccc(CCNCc2ccccc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)CCc1cc(OC(C)C)nn1Cc1ccc(Cl)cc1C.CO.Cc1ccccc1.O=C([O-])[C@H](O)[C@@H](O)C(=O)[O-].[H-].[K+].[Na+]>>Cc1cc(Cl)ccc1Cn1nc(OC(C)C)cc1CCCO",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc([C@H](C)NC(=O)c2c(C)sc(C)c2Cc2ccc(C(F)(F)F)cc2)cc1.Cl.[Li+].[OH-]>>Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(C(F)(F)F)cc1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCO.CCN(CC)CC.Clc1ccnc(Cl)n1.Nc1cccc(OCc2ccccc2)c1>>Clc1nccc(Nc2cccc(OCc3ccccc3)c2)n1",
        "output": "161"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)C[AlH]CC(C)C.CCOC(=O)C1CCc2c(sc3ncnc(Nc4ccc5[nH]c(=O)sc5c4)c23)C1.[Cl-].[NH4+]>>O=c1[nH]c2ccc(Nc3ncnc4sc5c(c34)CCC(CO)C5)cc2s1",
        "output": "225"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)Oc1cccc(C=O)c1.CCO.[BH4-].[Na+]>>CC(C)Oc1cccc(CO)c1",
        "output": "356"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].Cc1ccccc1.Nc1ccccc1Cl.O.O=P1(c2ccccc2)c2ccccc2-c2ccc(Br)cc21.[Fe+2].[Na+].[Pd+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=P1(c2ccccc2)c2ccccc2-c2ccc(Nc3ccccc3Cl)cc21",
        "output": "405"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.C1=CCCCC1.COc1ccc(-c2nn(C3CCCCC3)c3c(F)cccc23)cc1>>Oc1ccc(-c2nn(C3CCCCC3)c3c(F)cccc23)cc1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CCO.COc1nc(OC)nc(OC(C(=O)OCc2ccccc2)C(C)(C)C)n1.[C].[H][H].[Pd]>>COc1nc(OC)nc(OC(C(=O)O)C(C)(C)C)n1",
        "output": "186"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(c1ccccc1)c1ccc(CN)cc1.O=C(NC1(C(=O)O)CC1)c1cncnc1>>CCN(c1ccccc1)c1ccc(CNC(=O)C2(NC(=O)c3cncnc3)CC2)cc1",
        "output": "599"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.N[C@H](CO)c1cccc(Br)c1.O.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N[C@H](CO)c1cccc(Br)c1",
        "output": "686"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CO.II.O.O=C1c2ccccc2C(=O)N1CCCBr.[H-].[Na+]>>CN1CC[C@]23c4c5ccc(OCCCN6C(=O)c7ccccc7C6=O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCO.Cc1c(C)c2c(c(C)c1OCC(=O)O)C(=O)CC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2.Cl.O.O=C([O-])O.[Na+]>>CCOC(=O)COc1c(C)c(C)c2c(c1C)C(=O)CC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2",
        "output": "47"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)CC(C(=O)OCC)C(C)C.[Na+].[OH-]>>CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)CC(C(=O)O)C(C)C",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=[N+]([O-])c1cnccc1[C@H]1OC[C@H](COCc2ccccc2)O1>>Nc1cnccc1[C@H]1OC[C@H](COCc2ccccc2)O1",
        "output": "269"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCc1cc(OC)ccc1OC.ClCCCl.O=C(Cl)c1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>CCCc1cc(OC)c(C(=O)c2ccccc2)cc1OC",
        "output": "61"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cccc(C2(O)CCCNC2)c1.O=C(Cl)COc1ccccc1>>COc1cccc(C2(O)CCCN(C(=O)COc3ccccc3)C2)c1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.COc1cc([N+](=O)[O-])ccc1S.O=C([O-])[O-].OCCCBr.[K+].[K+]>>COc1cc([N+](=O)[O-])ccc1SCCCO",
        "output": "124"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCO.CCOC(=O)CCCN.COc1ccc(C=O)c(OC)c1.Cl.[Na+]>>CCOC(=O)CCCNCc1ccc(OC)cc1OC",
        "output": "468"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)/C=C(\\C)c1ccc(Br)cc1.OB(O)c1cccc(Cl)c1Cl>>CCOC(=O)/C=C(\\C)c1ccc(-c2cccc(Cl)c2Cl)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrC=C(c1ccccc1)c1ccncc1.CN(C)C=O.CN1CCc2[nH]c3ccc(Cl)cc3c2C1.O=C(O)[C@@H]1CCCN1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>CN1CCc2c(c3cc(Cl)ccc3n2/C=C(\\c2ccccc2)c2ccncc2)C1",
        "output": "987"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Br.COc1ccncc1[N+](=O)[O-].[Na+].[OH-]>>O=[N+]([O-])c1cnccc1O",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.ClCCl.O=C(N(Cc1ccnc2ccccc12)[C@H]1CCN[C@H](Cc2ccccc2)C1)C(F)(F)F.O=C(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>>O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](N(Cc2ccnc3ccccc23)C(=O)C(F)(F)F)C[C@H]1Cc1ccccc1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)C(N)C(=O)N1CCC(c2ccc(Cl)cc2)CC1.CCN(C(C)C)C(C)C.CN(C)C=O.CO.Cl.ClCCCl.O=C(O)c1ccccc1.On1nnc2ccccc21>>CC(C)(C)C(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1",
        "output": "718"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(C)=O.Cc1c(Oc2ccc(C#N)cn2)ccc2c1CCC2=O.O.O=C([O-])[O-].OO.[K+].[K+]>>Cc1c(Oc2ccc(C(N)=O)cn2)ccc2c1CCC2=O",
        "output": "677"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCNCC1.Cc1c(-c2csc(C(=O)O)c2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12>>Cc1c(-c2csc(C(=O)N3CCN(C)CC3)c2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12",
        "output": "857"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc2c(N3CCNCC3)cccc2n1.O=C1COc2c(F)cc(C(=O)CCl)cc2N1>>Cc1ccc2c(N3CCN(CC(=O)c4cc(F)c5c(c4)NC(=O)CO5)CC3)cccc2n1",
        "output": "414"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Nc1ccc(Br)cc1F.O=C(O)Cc1ccccc1Br>>O=C(O)Cc1ccccc1Nc1ccc(Br)cc1F",
        "output": "405"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)n1cc([N+](=O)[O-])cn1.CCO.[Pd]>>CC(C)n1cc(N)cn1",
        "output": "628"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1nc2ccc(Br)cc2n1C.CNCCNC.CS(C)=O.N.O=C([O-])[O-].O=c1cc(OCc2ccccc2)cc[nH]1.[Cu]I.[K+].[K+]>>CCc1nc2ccc(-n3ccc(OCc4ccccc4)cc3=O)cc2n1C",
        "output": "982"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CCS)C(=O)OC(C)(C)C.CN(C)C=O.FCCCBr.O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N[C@@H](CCSCCCF)C(=O)OC(C)(C)C",
        "output": "185"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[O-].CN1CCOCC1.C[C@@H](O)c1ccnc(N)n1.Fc1ncccc1C(F)(F)F.[K+]>>C[C@@H](Oc1ncccc1C(F)(F)F)c1ccnc(N)n1",
        "output": "541"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(C(=O)O)cc1F.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br.c1ccccc1>>O=C(O)c1ccc(CBr)c(F)c1",
        "output": "29"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C=C[C@@H]1C[C@]1(NC(=O)C1CN(C(=O)OC(C)(C)C)Cc2c[nH]nc21)C(=O)OCC.[Li+].[OH-]>>C=C[C@@H]1C[C@]1(NC(=O)C1CN(C(=O)OC(C)(C)C)Cc2c[nH]nc21)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1(C)COc2ccc(CC(N)C(O)c3cccc(Cl)c3)cc21.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.O.O=C(O)c1cccc2c1C=CCCC2.On1nnc2ccccc21>>CC1(C)COc2ccc(CC(NC(=O)c3cccc4c3C=CCCC4)C(O)c3cccc(Cl)c3)cc21",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNC1.CS(=O)(=O)OCCc1cc2cc(-c3ccc(C#N)cc3)ccc2o1>>N#Cc1ccc(-c2ccc3oc(CCN4CCCC4)cc3c2)cc1",
        "output": "496"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)C(C)(C)C1OC(c2cccc(OC)c2OC)c2cc(Cl)ccc2-n2cccc21.O.[Na+].[OH-]>>COc1cccc(C2OC(C(C)(C)C(=O)O)c3cccn3-c3ccc(Cl)cc32)c1OC",
        "output": "281"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCc1ccccc1.CC(C)=O.O.O=C([O-])[O-].Oc1ccc2ccc3cccc4ccc1c2c34.[K+].[K+]>>c1ccc(COc2ccc3ccc4cccc5ccc2c3c45)cc1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CI.COc1ccc(CC(=O)Nc2cc3cc(-c4cn[nH]c4)ccc3cn2)cc1.CS(C)=O.O=C([O-])[O-].[Cs+].[Cs+]>>COc1ccc(CC(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)cc1",
        "output": "229"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)[C@@H]1CC[C@@H](CNc2cc(OC)ccc2[N+](=O)[O-])CC1.[H][H].[Pd]>>COC(=O)[C@@H]1CC[C@@H](CNc2cc(OC)ccc2N)CC1",
        "output": "202"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.Clc1ccc(-n2c(-c3ccccc3Cl)nc3c(N[C@@H]4CCCNC4)ncnc32)cc1.c1ccncc1>>CC(=O)N1CCC[C@@H](Nc2ncnc3c2nc(-c2ccccc2Cl)n3-c2ccc(Cl)cc2)C1",
        "output": "369"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc2c(c1)C(=O)N([C@H](C)c1ccc(Cl)cc1)[C@@H](c1ccc(Cl)cc1)C(=O)N2CCCCC(=O)OC(C)(C)C.O.[Na+].[OH-]>>C[C@H](c1ccc(Cl)cc1)N1C(=O)c2cc(C(=O)O)ccc2N(CCCCC(=O)OC(C)(C)C)C(=O)[C@@H]1c1ccc(Cl)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O.COCC(=O)Cl.Nc1cc(Oc2cc(F)c(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)cc2F)ccn1>>COCC(=O)Nc1cc(Oc2cc(F)c(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)cc2F)ccn1",
        "output": "332"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=Cc1ccc(OS(=O)(=O)C(F)(F)F)c2ccccc12.OCCO>>O=S(=O)(Oc1ccc(C2OCCO2)c2ccccc12)C(F)(F)F",
        "output": "117"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COc1cc2c(cc1-c1cccs1)C(C)CN(C(=O)C(F)(F)F)CC2.O.[Na+].[OH-]>>COc1cc2c(cc1-c1cccs1)C(C)CNCC2",
        "output": "703"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=O.CC#N.CC(=O)Nc1ccc(C(F)(F)F)c(OC[C@H]2CCCN2)c1.CC(=O)O.[BH3-]C#N.[Na+]>>CC(=O)Nc1ccc(C(F)(F)F)c(OC[C@H]2CCCN2C)c1",
        "output": "217"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1cc2ccccc2c(-c2ccc(I)cc2)n1>>CNC(=O)c1cc2ccccc2c(-c2ccc(I)cc2)n1",
        "output": "137"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CN(C)C=O.COc1cccc(F)c1.O.[Li]CCCC>>COc1cccc(F)c1C=O",
        "output": "239"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.Cc1cc(C(N)=O)ccc1-n1c(CCC(=O)[O-])ccc1-c1ccc(-n2ccnc2)cc1.O.O.[Li]O>>Cc1cc(C(N)=O)ccc1-n1c(CCC(=O)O)ccc1-c1ccc(-n2ccnc2)cc1",
        "output": "151"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)COc1cc(C(=O)O)c(O)c2ccccc12.Cc1ccccc1.O=S(Cl)Cl.O=[N+]([O-])c1ccc(O)cc1>>CCOC(=O)COc1cc(C(=O)Oc2ccc([N+](=O)[O-])cc2)c(O)c2ccccc12",
        "output": "355"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(C)=O.N#Cc1cc([N+](=O)[O-])ccc1Cl.O.Oc1ccc(Cl)c(Cl)c1.[Na+].[OH-]>>N#Cc1cc([N+](=O)[O-])ccc1Oc1ccc(Cl)c(Cl)c1",
        "output": "299"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.Cc1cc(C=O)cc(C)c1O.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>Cc1cc(C=O)cc(C)c1OS(=O)(=O)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)N.ClCCl.O=C(Cl)C(Cl)Cl>>CC(C)NC(=O)C(Cl)Cl",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc2nsnc2c1.ClC(Cl)Cl.O=C1CCC(=O)N1Br>>BrCc1ccc2nsnc2c1",
        "output": "29"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)CSCc1ccc(Cl)cc1.NO>>O=C(CSCc1ccc(Cl)cc1)NO",
        "output": "376"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[Si](C)(C)[N-][Si](C)(C)C.Cc1cc(Br)cnc1N.[Na+]>>Cc1cc(Br)cnc1NC(=O)OC(C)(C)C",
        "output": "849"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].CCCCCCCC/C=C\\CCCCCCCCOc1cc(C=O)cc(OCCCCCCCC/C=C\\CCCCCCCC)c1.CCO.CNC.CO.Cl.N.[BH4-].[Na+].[Ti+4]>>CCCCCCCC/C=C\\CCCCCCCCOc1cc(CN(C)C)cc(OCCCCCCCC/C=C\\CCCCCCCC)c1",
        "output": "567"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.O=C(Cl)OCc1ccccc1.[N-]=[N+]=N[C@@H]1CNC[C@H]1F>>[N-]=[N+]=N[C@@H]1CN(C(=O)OCc2ccccc2)C[C@H]1F",
        "output": "427"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Cl.N#CSc1ccc(N)c([N+](=O)[O-])c1.O.[Fe]>>N#CSc1ccc(N)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CNC(=O)C(CO)OC.CS(=O)(=O)Cl.ClCCl>>CNC(=O)C(COS(C)(=O)=O)OC",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1=COCCC1.CCCCCC.OCCCCCCCCCCCCBr>>BrCCCCCCCCCCCCOC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1nc(-c2ccc(S(=O)(=O)NC(C)(C)C)c3ccccc23)n(CC2CCCCC2)c1C.Cl.O.[K+].[OH-]>>Cc1c(C(=O)O)nc(-c2ccc(S(=O)(=O)NC(C)(C)C)c3ccccc23)n1CC1CCCCC1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1nn(Cc2cccc(F)c2)c(C)c1-c1c[nH]c2ncc(-c3cccc(OC4CCN(C(=O)OC(C)(C)C)CC4)c3)cc12.Cl>>Cc1nn(Cc2cccc(F)c2)c(C)c1-c1c[nH]c2ncc(-c3cccc(OC4CCNCC4)c3)cc12",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)C(C)(C)Cc1c(SC(C)(C)C)c2cc(OC)ccc2n1Cc1ccc(Cl)cc1.Cl.[Li+].[OH-]>>COc1ccc2c(c1)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc1ccc(Cl)cc1",
        "output": "361"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(=O)Cl.CC(C)(C)OC(=O)N1CCC(c2ccc(OCCCO)cc2)C(OCc2ccc3ccccc3c2)C1>>CC(C)(C)OC(=O)N1CCC(c2ccc(OCCCOC(=O)C(C)(C)C)cc2)C(OCc2ccc3ccccc3c2)C1",
        "output": "126"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1noc(-c2ccc(-c3ccc(C4(C(=O)O)CC4)cc3)cc2)c1CSCc1ccccc1.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cc1noc(-c2ccc(-c3ccc(C4(C(=O)O)CC4)cc3)cc2)c1CS(=O)Cc1ccccc1",
        "output": "13"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCP(=O)=O.CCNC.CCOC(C)=O.Cn1ncc(C(=O)O)c1C(=O)Nc1ccn2nc(-c3ccccc3)nc2c1>>CCN(C)C(=O)c1cnn(C)c1C(=O)Nc1ccn2nc(-c3ccccc3)nc2c1",
        "output": "733"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO[C@@H](Cc1ccc(OCc2nc(-c3ccc(F)c(C)c3)oc2C)cc1CC)C(=O)OC.[Li+].[OH-]>>CCO[C@@H](Cc1ccc(OCc2nc(-c3ccc(F)c(C)c3)oc2C)cc1CC)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@@H](O)C[C@@H]1O[Si](C)(C)C(C)(C)C.Fc1c(Cl)ncnc1Cl.[H-].[Na+]>>CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@@H](Oc2ncnc(Cl)c2F)C[C@@H]1O[Si](C)(C)C(C)(C)C",
        "output": "461"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCCBr.CC#N.CCOC(=O)Cc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)Cc1ccc(OCCBr)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.COc1ccc(N)cc1Cl.COc1ccc(Nc2nc(Cl)nc(Cl)n2)cc1Cl.Clc1nc(Cl)nc(Cl)n1.NC1CCCCCC1.[Na+].[OH-]>>COc1ccc(Nc2nc(Cl)nc(NC3CCCCCC3)n2)cc1Cl",
        "output": "578"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.NS(=O)(=O)c1cnn2c(Nc3cccc(Cl)c3Cl)c(C(=O)N3CCC(c4ccc(F)cc4)CC3)cnc12>>CC(=O)NS(=O)(=O)c1cnn2c(Nc3cccc(Cl)c3Cl)c(C(=O)N3CCC(c4ccc(F)cc4)CC3)cnc12",
        "output": "801"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C1COCCO1.CC(C)O.COCOc1cc(-c2nc(C)no2)ccc1C.Cl>>Cc1noc(-c2ccc(C)c(O)c2)n1",
        "output": "755"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(C)c2c(C(C)C)cc(O)nc12.Cc1ccccc1.O=P(Cl)(Cl)Cl>>Cc1ccc(C)c2c(C(C)C)cc(Cl)nc12",
        "output": "41"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCCOC.N#Cc1ccnc(Cl)c1.O.O=C([O-])O.OB(O)c1ccc(C(F)(F)F)cc1.[Na+]>>N#Cc1ccnc(-c2ccc(C(F)(F)F)cc2)c1",
        "output": "865"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOc1ccc(C2CCC(CCl)CC2)c(F)c1F.CCOc1ccc(O)c(F)c1F.CN(C)C=O.O=P([O-])([O-])[O-].[K+].[K+].[K+]>>CCOc1ccc(OCC2CCC(c3ccc(OCC)c(F)c3F)CC2)c(F)c1F",
        "output": "74"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C1CCOC1.CC(C)(C)OC(=O)CBr.CN(C)C=O.OCCOCCOCCOCCOCCOc1cc(OCCOCCOCCOCCOCCOCc2ccccc2)cc(OCCOCCOCCOCCOCCOCc2ccccc2)c1.[H-].[Na+]>>CC(C)(C)OC(=O)COCCOCCOCCOCCOCCOc1cc(OCCOCCOCCOCCOCCOCc2ccccc2)cc(OCCOCCOCCOCCOCCOCc2ccccc2)c1",
        "output": "669"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CN1CCN(c2cncc(CC(=O)OC(C)(C)C)c2)CC1.Cl>>CN1CCN(c2cncc(CC(=O)O)c2)CC1",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCOC(C)=O.CN(C)CC(=O)O.COc1ccc(O)cc1.Cl.N#Cc1ccc(I)cc1.O.O=C([O-])[O-].[Cs+].[Cs+]>>COc1ccc(Oc2ccc(C#N)cc2)cc1",
        "output": "382"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)C(C#N)C1(C2CCCC2)CCN(C(=O)OC(C)(C)C)CC1.O.[K+].[OH-]>>CC(C)(C)OC(=O)N1CCC(C2CCCC2)(C(C#N)C(=O)O)CC1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CC(CC(C)C)C(=O)O.CN1CCOCC1.ClCCCl.NCCc1ccc(-c2ccccc2)cc1.On1nnc2ccccc21>>CCOC(=O)CC(CC(C)C)C(=O)NCCc1ccc(-c2ccccc2)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)C1CCN(c2ccc(NC(=O)c3nc(-c4ccccc4)oc3C(F)(F)F)cc2)CC1.[Na+].[OH-]>>O=C(Nc1ccc(N2CCC(C(=O)O)CC2)cc1)c1nc(-c2ccccc2)oc1C(F)(F)F",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(C)=O.N#Cc1ccc(Oc2ccc(C=O)s2)cc1.O=C([O-])[O-].OO.[K+].[K+]>>NC(=O)c1ccc(Oc2ccc(C=O)s2)cc1",
        "output": "180"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)Cl)cc4c3OCC4)nc12.CN1CCNCC1>>CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)cc4c3OCC4)nc12",
        "output": "99"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(C)=O.CN(C)C=O.Nc1c(Br)cc([N+](=O)[O-])cc1Br.[H][H].[Pt]>>Nc1cc(Br)c(N)c(Br)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1=COCCC1.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.O=C(Cc1ccc(F)cc1)c1ccc(O)cc1O.c1cc[nH+]cc1>>O=C(Cc1ccc(F)cc1)c1ccc(OC2CCCCO2)cc1O",
        "output": "319"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COc1cc(C)c(S(=O)(=O)Cl)c(C)c1.Cl.ClCCl.OC[C@@H]1CCCCN1>>COc1cc(C)c(S(=O)(=O)N2CCCC[C@H]2CO)c(C)c1",
        "output": "99"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cccc2c(COc3cccc4[nH]c(C(=O)O)cc34)coc12.C[C@H]1CN(CCC2(O)CCC(N)CC2)CC[C@@H]1O>>COc1cccc2c(COc3cccc4[nH]c(C(=O)NC5CCC(O)(CCN6CC[C@H](O)[C@@H](C)C6)CC5)cc34)coc12",
        "output": "137"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.Cl.OCC1CC=CCC1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCC2CC=CCC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCN=C=NCCCN(C)C.CCOc1ccc(C(=O)CCC(=O)O)cc1.CN(C)C=O.Nc1cc(-c2ccccc2)c2ccccc2n1.On1nnc2ccccc21>>CCOc1ccc(C(=O)CCC(=O)Nc2cc(-c3ccccc3)c3ccccc3n2)cc1",
        "output": "368"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CC(=O)O.CC1CCCCC1.COC(=O)CC(C)=O.O.O=Cc1ccc(O)cc1>>COC(=O)CC(=O)C=Cc1ccc(O)cc1",
        "output": "295"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cccc(F)c1.O=C(Cl)c1ccc(F)cc1.O=[N+]([O-])c1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>COc1ccc(C(=O)c2ccc(F)cc2)c(F)c1",
        "output": "61"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.[OH-].[OH-].[Pd+2].c1ccc(CN2CCC(Cc3ccccc3)(c3c[nH]c4ccccc34)C2)cc1>>c1ccc(CC2(c3c[nH]c4ccccc34)CCNC2)cc1",
        "output": "84"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCC.CN(C)C=O.Cc1cc(O)cc(C)c1Br.Cc1ccc(S(=O)(=O)OCC(C)(C)C#N)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1cc(OCC(C)(C)C#N)cc(C)c1Br",
        "output": "438"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NCCc1ccccc1.Nc1nc(Cl)nc2nc[nH]c12>>Nc1nc(NCCc2ccccc2)nc2nc[nH]c12",
        "output": "544"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.CC(=O)O.COc1ccc(C(=O)c2ccc([N+](=O)[O-])cc2)cc1>>O=C(c1ccc(O)cc1)c1ccc([N+](=O)[O-])cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)CCCOc1ccc2[nH]cc(CCNC(C)=O)c2c1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC(=O)NCCc1c[nH]c2ccc(OCCCCO)cc12",
        "output": "225"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cc1ccc2c(C3=CCN(C(=O)OC(C)(C)C)CC3)cc(F)cc2n1.[Pd]>>Cc1ccc2c(C3CCN(C(=O)OC(C)(C)C)CC3)cc(F)cc2n1",
        "output": "806"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(-c2c[nH]nc2C(F)(F)F)cc1C(SC(c1cc(-c2c[nH]nc2C(F)(F)F)ccc1C)C(F)(F)F)C(F)(F)F.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.O=S([O-])[O-].[Na+].[Na+]>>Cc1ccc(-c2c[nH]nc2C(F)(F)F)cc1C(S(=O)C(c1cc(-c2c[nH]nc2C(F)(F)F)ccc1C)C(F)(F)F)C(F)(F)F",
        "output": "13"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "FC(F)(F)c1ccc(N2CCNCC2)cc1.O=C(Cl)c1cc(Br)ccc1N1CCOCC1>>O=C(c1cc(Br)ccc1N1CCOCC1)N1CCN(c2ccc(C(F)(F)F)cc2)CC1",
        "output": "201"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4Nc4cccc(Br)n4)cc3)cc2)CC1.OB(O)c1cccc(F)c1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4Nc4cccc(-c5cccc(F)c5)n4)cc3)cc2)CC1",
        "output": "869"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Nc1ccc(Oc2ccnc(N)c2[N+](=O)[O-])cc1Cl.O=C=Nc1ccc(Cl)c(C(F)(F)F)c1>>Nc1nccc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(Cl)c2)c1[N+](=O)[O-]",
        "output": "912"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(NC(=O)OC(C)(C)C)CCNCC1.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[P-](F)(F)(F)(F)F.N#Cc1ccc(-c2cnn3ccc(-c4ccc(C(=O)O)cc4)nc23)cc1>>CC1(NC(=O)OC(C)(C)C)CCN(C(=O)c2ccc(-c3ccn4ncc(-c5ccc(C#N)cc5)c4n3)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CCO.CCOC(=O)C(C)(C)Oc1cc(OC)cc(C(=O)NC2CCNCC2)c1.CCOc1cc(C=O)ccc1OC.[BH3-]C#N.[Na+]>>CCOC(=O)C(C)(C)Oc1cc(OC)cc(C(=O)NC2CCN(Cc3ccc(OC)c(OCC)c3)CC2)c1",
        "output": "567"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COC(=O)CN1CCN(C)CC1.NN.O>>CN1CCN(CC(=O)NN)CC1",
        "output": "130"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1cc(C=O)ccc1O.ClCCCl.O=C([O-])[O-].[K+].[K+]>>COc1cc(C=O)ccc1OCCCl",
        "output": "74"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCOC(C)=O.Cl.N[C@@H]1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(SCSc3c[nH]nn3)CS[C@H]12.O=CO>>N[C@@H]1C(=O)N2C(C(=O)O)=C(SCSc3c[nH]nn3)CS[C@H]12",
        "output": "228"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CCOC(=O)C(C)(C)c1cccc(OCC)c1.ClI.O>>CCOC(=O)C(C)(C)c1ccc(I)c(OCC)c1",
        "output": "466"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)N1CCC(O)CC1.CC(C)(C)OC(=O)/N=N/C(=O)OC(C)(C)C.COC(=O)Cc1ccccc1O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(=O)Cc1ccccc1OC1CCN(C(C)=O)CC1",
        "output": "846"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NC(Cc1ccc(Cl)cc1)C(=O)NCCCOc1ccc(Cl)cc1NC(=O)Nc1ccc(C#N)cn1.CO.Cl>>N#Cc1ccc(NC(=O)Nc2cc(Cl)ccc2OCCCNC(=O)C(N)Cc2ccc(Cl)cc2)nc1",
        "output": "431"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.Cl.NCc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O.O=C=Nc1ccccc1>>O=C1CCC(N2C(=O)c3ccc(CNC(=O)Nc4ccccc4)cc3C2=O)C(=O)N1",
        "output": "814"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nn1nc(N2CCOCC2)c2ccccc2c1=O.O=C(O)Cc1cccc(OC(F)(F)F)c1>>O=C(Cc1cccc(OC(F)(F)F)c1)Nn1nc(N2CCOCC2)c2ccccc2c1=O",
        "output": "459"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(=O)OC(C)(C)C(=O)Nc1sccc1C(N)=O.O.O=C1CCC(=O)N1Br>>CC(=O)OC(C)(C)C(=O)Nc1sc(Br)cc1C(N)=O",
        "output": "807"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.C[C@](N)(C#N)Cn1cc2ncc(Br)cc2n1.O=C(Cl)c1ccc(OC(F)(F)F)cc1>>C[C@](C#N)(Cn1cc2ncc(Br)cc2n1)NC(=O)c1ccc(OC(F)(F)F)cc1",
        "output": "271"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrBr.CC(=O)O.Nc1nc(Cl)cc(-c2ccccc2)n1>>Nc1nc(Cl)c(Br)c(-c2ccccc2)n1",
        "output": "381"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)[O-].CN1CCCC1=O.COC(C)(C)C.Fc1ccc(SC(c2ccccc2)(c2ccccc2)c2ccccc2)c(C(F)(F)F)c1.O.O.OCC(F)(F)F.[Cl-].[Cl-].[K+].[Na+].[Na+]>>FC(F)(F)COc1ccc(SC(c2ccccc2)(c2ccccc2)c2ccccc2)c(C(F)(F)F)c1",
        "output": "485"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COc1c(NC(=O)Oc2ccccc2)cc(C(C)(C)C)cc1N(CCOCc1ccccc1)S(C)(=O)=O.[Pd]>>COc1c(NC(=O)Oc2ccccc2)cc(C(C)(C)C)cc1N(CCO)S(C)(=O)=O",
        "output": "178"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=Cc1ccccc1.CCN(CC)CC.COc1ccc(I)cc1>>COc1ccc(/C=C/c2ccccc2)cc1",
        "output": "725"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)C1CCN(C(=O)c2cccc([C@H](c3cccc(O)c3)N3C[C@@H](C)N(Cc4cccc(F)c4)C[C@@H]3C)c2)CC1.CO.Cl.O.[Na+].[OH-]>>C[C@@H]1CN([C@@H](c2cccc(O)c2)c2cccc(C(=O)N3CCC(C(=O)O)CC3)c2)[C@@H](C)CN1Cc1cccc(F)c1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cn1c2c(c3cc(C(=O)O)ccc31)CC(C1CCOCC1)CC2.F[P-](F)(F)(F)(F)F.O=C(NC1CC1)C1CC[NH2+]C1.[Cl-]>>Cn1c2c(c3cc(C(=O)N4CCC(C(=O)NC5CC5)C4)ccc31)CC(C1CCOCC1)CC2",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1cccc(Br)n1.CCO.CN>>CNc1cccc(Br)n1",
        "output": "715"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N(CC(F)(F)F)c1cc(N2CCSCC2)cc(CO)n1.CCN(CC)CC.CS(C)=O.ClC(Cl)Cl.O>>CC(C)(C)OC(=O)N(CC(F)(F)F)c1cc(N2CCSCC2)cc(C=O)n1",
        "output": "263"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.Cl.ClCCl.c1ccc2sc(Oc3ccc(CN4C[C@@H]5C[C@H]4CN5)cc3)nc2c1>>CC(=O)N1C[C@@H]2C[C@H]1CN2Cc1ccc(Oc2nc3ccccc3s2)cc1",
        "output": "369"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COCCN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-n3ccnn3)c2)cc1Cl.ClCCl.O=C(O)C(F)(F)F>>COCCN(C)c1cc2c(cc1Cl)NC(=O)CC(c1cccc(-n3ccnn3)c1)=N2",
        "output": "930"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)c1cc(C(C)C)c(-c2cccc(P(C3CCCCC3)C3CCCCC3)c2)c(C(C)C)c1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CC1CNc2cc(C#N)c(Br)cc2N1C.Cl[Pd+].Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.Nc1ccccc1-c1[c-]cccc1.O.O=C([O-])[O-].[Na+].[Na+]>>CC1CNc2cc(C#N)c(-c3cnn(C)c3)cc2N1C",
        "output": "971"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCN2C[C@@H](N)C[C@H]2C1.Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)O)n2c1.Cl.Cl.Cl.F[P-](F)(F)(F)(F)F.O.O.O=C(O)C(F)(F)F>>Cc1cc(OCc2c(F)cccc2F)c2nc(C)c(C(=O)N[C@H]3C[C@H]4CN(C)CCN4C3)n2c1",
        "output": "697"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.COC(CO)CO[Si](C)(C)C(C)(C)C.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>COC(C=O)CO[Si](C)(C)C(C)(C)C",
        "output": "142"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)[O-].CC(C)(C)[Si](C)(C)OCC1CCNCC1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCOC(C)=O.Clc1ccc(Br)cn1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CC(C)(C)[Si](C)(C)OCC1CCN(c2ccc(Cl)nc2)CC1",
        "output": "597"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cl.ClCCl.Nc1cc(Cl)c(-c2ccc(S(=O)(=O)N3CCOCC3)cc2)c(C(F)(F)F)c1.O.O=C([O-])[O-].S=C(Cl)Cl.[Ca+2]>>O=S(=O)(c1ccc(-c2c(Cl)cc(N=C=S)cc2C(F)(F)F)cc1)N1CCOCC1",
        "output": "114"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)c1cccn(Cc2cccc(Br)c2)c1=O.[Na+].[OH-]>>CC(C)(C)OC(=O)NCCC[C@H](NC(=O)c1cccn(Cc2cccc(Br)c2)c1=O)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCc1nn(-c2ccccc2)c(C)c1CC(=O)O.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.NCc1ccc(F)cc1Cl.On1nnc2ccccc21>>CCCCc1nn(-c2ccccc2)c(C)c1CC(=O)NCc1ccc(F)cc1Cl",
        "output": "599"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)/C=C(C)/C=C/C=C(/CC)c1cc2c(cc1OCC)C(C)(C)CC=C2C(C)(C)C.[Na+].[OH-]>>CCOc1cc2c(cc1/C(=C\\C=C\\C(C)=C\\C(=O)O)CC)C(C(C)(C)C)=CCC2(C)C",
        "output": "122"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C(=O)N1CC=C(c2cc3c(-c4ccc(F)c(N)c4)ncnc3[nH]2)CC1.CN(C)c1ccncc1.O=C(Cl)c1ccc(C2CC2)cc1.c1ccncc1>>CN(C)C(=O)N1CC=C(c2cc3c(-c4ccc(F)c(NC(=O)c5ccc(C6CC6)cc5)c4)ncnc3[nH]2)CC1",
        "output": "11"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCOP(=O)(C#N)OCC.Cl.ClCCl.O.O=C(O)c1ccc2c(c1)C(=O)c1ccccc1C2=O.c1cc2c(o1)CCNC2>>O=C1c2ccccc2C(=O)c2cc(C(=O)N3CCc4occc4C3)ccc21",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)Cn1c(CN2C(=O)OC3(CCNCC3)C2=O)cc2cnc(C#N)nc21.CCBr.CN(C)C=O.O.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CCN1CCC2(CC1)OC(=O)N(Cc1cc3cnc(C#N)nc3n1CC(C)(C)C)C2=O",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(Cl)C(=O)Cl.CCN(CC)CC.COC(=O)CCN.Cl.ClCCl.c1ccncc1>>COC(=O)CCNC(=O)C(C)Cl",
        "output": "45"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COc1cccc(N=C=O)c1.ClCCl.O=C1Nc2cc(Cl)ccc2C1(Cc1cccc(Cl)c1)C1CCCNC1>>COc1cccc(NC(=O)N2CCCC(C3(Cc4cccc(Cl)c4)C(=O)Nc4cc(Cl)ccc43)C2)c1",
        "output": "323"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCCCCC(=O)OCc1nccc(O)n1.CC[N+](CC)(CC)CC.CN(C)c1ccccc1.O=P(Cl)(Cl)Cl.[Cl-]>>CCCCCC(=O)OCc1nccc(Cl)n1",
        "output": "25"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NCCBr.CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@H](N)C2)c(C(F)(F)F)c1>>CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@H](NCCNC(=O)OC(C)(C)C)C2)c(C(F)(F)F)c1",
        "output": "147"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cc1ccc2c(c1)[nH]c(=O)n2CCCOS(C)(=O)=O.Cl.O=C([O-])[O-].O=C(c1ccc(F)cc1)C1CCNCC1.[Na+].[Na+]>>Cc1ccc2c(c1)[nH]c(=O)n2CCCN1CCC(C(=O)c2ccc(F)cc2)CC1",
        "output": "496"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCc1ccc(O[C@H](C)CCOc2ccc(CCC(=O)OC)c(C)c2)c(C(C)(C)c2ccccc2)c1.CO.Cl.O.[Na+].[OH-]>>CCc1ccc(O[C@H](C)CCOc2ccc(CCC(=O)O)c(C)c2)c(C(C)(C)c2ccccc2)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COc1ccc(B(O)O)cc1.Cc1cc(Br)ccc1C(=O)O.Cc1ccccc1.O.O=C([O-])[O-].[Na+].[Na+]>>COc1ccc(-c2ccc(C(=O)O)c(C)c2)cc1",
        "output": "837"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.COCC(COC)Oc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc2cc(C(=O)O)[nH]c12.Cl.On1nnc2ccccc21.[NH4+].[OH-]>>COCC(COC)Oc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc2cc(C(N)=O)[nH]c12",
        "output": "136"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)[O-].CS(=O)(=O)c1nc(Cl)cc(C(F)(F)F)n1.OC1CCCC1.[K+]>>FC(F)(F)c1cc(Cl)nc(OC2CCCC2)n1",
        "output": "667"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Clc1nc2ccccc2[nH]1.NC1CCc2cc(Br)ccc21>>Brc1ccc2c(c1)CCC2Nc1nc2ccccc2[nH]1",
        "output": "364"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CCOc1ccc(N)cc1Br.O=C(O)COc1ccc(C(F)(F)F)cc1Cl>>CCN(CC)CCOc1ccc(NC(=O)COc2ccc(C(F)(F)F)cc2Cl)cc1Br",
        "output": "646"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "B.CC(C(N)=O)N1CCC(C(F)F)c2ccccc21.CSC>>CC(CN)N1CCC(C(F)F)c2ccccc21",
        "output": "112"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.Cc1cc(Cl)c(Cl)cc1[N+](=O)[O-].O.[Cl-].[Fe].[NH4+]>>Cc1cc(Cl)c(Cl)cc1N",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Cc1ccc(-c2nc3cc(F)cc(F)c3c(Cl)c2C)nc1.Cc1ccccc1.Nc1cncc(N2CCOCC2)c1.[Na+]>>Cc1ccc(-c2nc3cc(F)cc(F)c3c(Nc3cncc(N4CCOCC4)c3)c2C)nc1",
        "output": "859"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)c1ccc(-c2cccc(C3Nc4c(cc(Cl)cc4C(=O)O)CC3(C)C)c2)cc1.CN(C)C=O.CS(N)(=O)=O.O=C(n1ccnc1)n1ccnc1.[H-].[Na+]>>CC(C)(C)c1ccc(-c2cccc(C3Nc4c(cc(Cl)cc4C(=O)NS(C)(=O)=O)CC3(C)C)c2)cc1",
        "output": "580"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(Cl)C(Cl)(Cl)Cl.O=C(c1ccccc1)c1cc([N+](=O)[O-])ccc1NCC(F)(F)F>>O=C(c1ccccc1)c1cc([N+](=O)[O-])ccc1N(CC(F)(F)F)C(=O)C(Cl)(Cl)Cl",
        "output": "160"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)CNC(=O)c1c(O)ccc2nc(NCc3ccccc3)c(-c3ccccc3)nc12.[Na+].[OH-]>>O=C(O)CNC(=O)c1c(O)ccc2nc(NCc3ccccc3)c(-c3ccccc3)nc12",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C=C[C@H]1CCN(C(=O)OC(C)(C)C)[C@@H]1CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C.CCCC[N+](CCCC)(CCCC)CCCC.O.[F-]>>C=C[C@H]1CCN(C(=O)OC(C)(C)C)[C@@H]1CO",
        "output": "781"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOCC.COc1cccc2c1CC(C)(C)C2=O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COc1cccc2c1CC(C)(C)C2O",
        "output": "24"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COc1cccc(C(O)C[N+](=O)[O-])c1.O=C[O-].[C].[NH4+].[Pd]>>COc1cccc(C(O)CN)c1",
        "output": "226"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cccc(-c2[nH]c(C(C)C)nc2-c2cccc(Br)c2)n1.OB(O)c1ccc(C(F)(F)F)cc1>>Cc1cccc(-c2[nH]c(C(C)C)nc2-c2cccc(-c3ccc(C(F)(F)F)cc3)c2)n1",
        "output": "837"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(O)CCc1ccc(O)cc1.O.OCCBr.[I-].[Na+].[Na+].[OH-]>>CC(C)(O)CCc1ccc(OCCO)cc1",
        "output": "75"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CC(C)S.CCOC(C)=O.O=C(Nc1cc2ccc(Br)cc2cn1)C1CC1.[Fe+2].[Na+].[Pd+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)Sc1ccc2cc(NC(=O)C3CC3)ncc2c1",
        "output": "824"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(CC(=O)Cl)N=[N+]=[N-].CCN(C(C)C)C(C)C.CCNC.ClCCl>>CCN(C)C(=O)CC(C)(C)N=[N+]=[N-]",
        "output": "125"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)(CN)C(=O)O.CCN(C(C)C)C(C)C.CN(C)C=O>>CC(C)(C)OC(=O)NCC(C)(C)C(=O)O",
        "output": "631"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN1CCNCC1.Clc1cc(Cl)ncn1>>CN1CCN(c2cc(Cl)ncn2)CC1",
        "output": "162"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.CI.Cc1cc(O)ccc1Br.O=C([O-])[O-].[K+].[K+]>>COc1ccc(Br)c(C)c1",
        "output": "62"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCC(=O)N1CCC(NC(=O)c2cc3ccccc3cc2NC(=O)Nc2c(C)cc(C)cc2C)(C(=O)OC)CC1.CO.Cl.[Li+].[OH-]>>CCCC(=O)N1CCC(NC(=O)c2cc3ccccc3cc2NC(=O)Nc2c(C)cc(C)cc2C)(C(=O)O)CC1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#C[C@@H](CC(=O)OCC)c1ccc(O)cc1.CCCCP(CCCC)CCCC.Cc1ccccc1.Cc1cnc(Cl)cc1-c1csc2ccc(CO)cc12.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CC#C[C@@H](CC(=O)OCC)c1ccc(OCc2ccc3scc(-c4cc(Cl)ncc4C)c3c2)cc1",
        "output": "347"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)COc1ccc(CC(C)(C)[N+](=O)[O-])cc1.O=[Pt].[H][H]>>CCOC(=O)COc1ccc(CC(C)(C)N)cc1",
        "output": "226"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCCCC[C@H](CO)C(=O)O.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.Cl.ClCCl.NOCc1ccccc1>>C=CCCCC[C@H](CO)C(=O)NOCc1ccccc1",
        "output": "480"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CNCC/C=C/c1cccnc1>>CN(CC/C=C/c1cccnc1)C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Fc1cnc(Cl)nc1Cl.Nc1ccccc1>>Fc1cnc(Cl)nc1Nc1ccccc1",
        "output": "161"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc(C(CC(=O)c2ccncc2)c2ccc(N(C)C)cc2)cc1C.Cl.NO.O=C([O-])O.[Na+]>>Cc1ccc(C(CC(=NO)c2ccncc2)c2ccc(N(C)C)cc2)cc1C",
        "output": "212"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nc1ccc(O)c(C(=O)O)c1.O=[N+]([O-])c1ccc(CBr)cc1>>O=C(O)c1cc(NCc2ccc([N+](=O)[O-])cc2)ccc1O",
        "output": "272"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.OCc1ccccc1CCCCCCCBr.[Mn+2].[O-2]>>O=Cc1ccccc1CCCCCCCBr",
        "output": "179"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)C1C(c2cccc(Cl)c2F)C(C#N)(c2ccc(Cl)cc2F)C(CC(C)(C)C)N1C=O.Cl.[Na+].[OH-]>>CC(C)(C)CC1N(C=O)C(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCN(C(C)=O)c1cc(C(=O)OCC)cc(Cl)n1.CO.[Na+].[OH-]>>C=CCN(C(C)=O)c1cc(C(=O)O)cc(Cl)n1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.NC(=O)c1cn2ccc([N+](=O)[O-])cc2n1.[Pd]>>NC(=O)c1cn2ccc(N)cc2n1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=O.CC(=O)O.CC(=O)[O-].CC(C)(C)c1cc(CO)cc(C(C)(C)C)c1O.O.[NH4+]>>CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O",
        "output": "179"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cccc(C(F)(F)F)c1F>>O=C(Cl)c1cccc(C(F)(F)F)c1F",
        "output": "448"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)c1c(Br)cc2ccc(C=O)nc2c1C#N.CO.[BH4-].[Na+]>>CN(C)c1c(Br)cc2ccc(CO)nc2c1C#N",
        "output": "745"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)C(F)(F)c1ccc(OC(F)(F)F)cc1F.CO.O.O.[Li+].[OH-]>>O=C(O)C(F)(F)c1ccc(OC(F)(F)F)cc1F",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1nnc(-c2cccc(Br)c2)o1.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1nnc(-c2cccc(B3OC(C)(C)C(C)(C)O3)c2)o1",
        "output": "942"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.CO.C[O-].Clc1ccc(Br)cn1.O.[Na+]>>COc1ccc(Br)cn1",
        "output": "433"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCc1ccc(NS(=O)(=O)c2ccccc2C(=O)OC)cc1.Cl.O.[Na+].[OH-]>>CCCCc1ccc(NS(=O)(=O)c2ccccc2C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C)(C)Oc1ccc(OCCc2cc(-c3ccc(OC(F)(F)F)cc3)nn2C)cc1C.[Li+].[OH-]>>Cc1cc(OCCc2cc(-c3ccc(OC(F)(F)F)cc3)nn2C)ccc1OC(C)(C)C(=O)O",
        "output": "192"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.N#Cc1ccc(F)cc1F.OCc1ccccc1.[H-].[Na+]>>N#Cc1ccc(F)cc1OCc1ccccc1",
        "output": "485"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.F[C@@H]1CCNC1.O=C(NCC1CCCC(F)(F)C1)c1c(Cl)ccc2nc(Cl)ccc12>>O=C(NCC1CCCC(F)(F)C1)c1c(Cl)ccc2nc(N3CC[C@@H](F)C3)ccc12",
        "output": "220"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NCC(c1cnc(C(F)(F)F)nc1)N1CCC(F)(F)CC1.O=C(O)c1ccccc1Cl>>O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1ccccc1Cl",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CO.COc1cc2c(cc1OC)CN(CCc1ccc([N+](=O)[O-])cc1)CC2.Cl.ClC(Cl)Cl.ClCCl.O.[Fe].[Na+].[OH-]>>COc1cc2c(cc1OC)CN(CCc1ccc(N)cc1)CC2",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.OCCOc1c(Cl)cc(OCc2ccccc2)cc1Cl.[H][H].[Pd]>>OCCOc1c(Cl)cc(O)cc1Cl",
        "output": "23"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Oc1ccc(Cl)c(Cl)c1.Oc1nc(Cl)nc2cnccc12>>Oc1nc(Oc2ccc(Cl)c(Cl)c2)nc2cnccc12",
        "output": "542"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1nc(Br)ccc1O.[K+].[K+]>>O=[N+]([O-])c1nc(Br)ccc1OCc1ccccc1",
        "output": "623"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)c1cccc(C(F)(F)F)c1.CO.Cl.NO.O.O.O.[Na+]>>CC(=NO)c1cccc(C(F)(F)F)c1",
        "output": "212"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CN1CCNCC1.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1Cl.[K+].[K+]>>CN1CCN(c2ccc([N+](=O)[O-])c(Cl)c2)CC1",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCc2cc(N3CCN(C4CCCC4)CC3)ccc2C1.Cl>>c1cc2c(cc1N1CCN(C3CCCC3)CC1)CCNC2",
        "output": "887"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)CCC(C=O)NC(=O)C1CCCN2C(=O)CCC(NC(=O)c3ccccc3)C(=O)N12.ClC(Cl)Cl.ClCCl.O=C(O)C(F)(F)F.[Br-].[K+]>>O=CC(CCC(=O)O)NC(=O)C1CCCN2C(=O)CCC(NC(=O)c3ccccc3)C(=O)N12",
        "output": "278"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccccc1.C1CCOC1.O=C(O)CO.[H-].[Na+]>>O=C(CO)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CCOC(=O)C(C)(C)Oc1ccc(OCCc2nc(-c3ccc(O)cc3)oc2C)cc1.OC1CCCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)C(C)(C)Oc1ccc(OCCc2nc(-c3ccc(OC4CCCCC4)cc3)oc2C)cc1",
        "output": "846"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "NCC(O)(Cn1cncn1)c1ccc(F)cc1F.O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1>>O=S(=O)(NCC(O)(Cn1cncn1)c1ccc(F)cc1F)c1ccc(C(F)(F)F)cc1",
        "output": "43"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=Cc1ccc(C=C)cc1.C=Cc1ccccc1.CCN(CC)Cc1ccccc1.ClCCl.O=C(Cl)C1CCCC1.c1cc2c(cc1OC1CCNCC1)CCN(C1CCC1)CC2>>O=C(C1CCCC1)N1CCC(Oc2ccc3c(c2)CCN(C2CCC2)CC3)CC1",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=[N+]([O-])c1ccc(-c2nnc(O)o2)cc1.[H][H].[Pd]>>Nc1ccc(-c2nnc(O)o2)cc1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C[C@H](NC(=O)C1=C(O)c2ccc(Br)cc2C(C)(C)C1=O)C(=O)OC(C)(C)C.O.O=C(O)C(F)(F)F>>C[C@H](NC(=O)C1=C(O)c2ccc(Br)cc2C(C)(C)C1=O)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cncc(F)c1.O=C(O)c1cc(Br)ccc1OCc1ccccc1>>O=C(Nc1cncc(F)c1)c1cc(Br)ccc1OCc1ccccc1",
        "output": "759"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Clc1ccc2ncnc(N3CCOCC3)c2n1.OB(O)c1ccc(Cl)cc1>>Clc1ccc(-c2ccc3ncnc(N4CCOCC4)c3n2)cc1",
        "output": "865"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)CC1NC(C(=O)Nc2ccn(CCO[Si](C)(C)C(C)(C)C)c(=O)c2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F.Cl>>CC(C)(C)CC1NC(C(=O)Nc2ccn(CCO)c(=O)c2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F",
        "output": "708"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#CCC(C)(C)CO.C1CCNCC1.FC(F)(F)Oc1ccc(I)cc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CC(C)(CO)CC#Cc1ccc(OC(F)(F)F)cc1",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCC(=O)O.CCN(CC)CC.CCN(CC)CCNc1ccc2ncn3c4ccc(O)cc4c(=O)c1c23.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.CO.Cl.ClC(Cl)Cl>>CCCCCC(=O)Oc1ccc2c(c1)c(=O)c1c(NCCN(CC)CC)ccc3ncn2c31",
        "output": "108"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#Cc1ccc(OC(F)F)c(CC)c1.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Fc1ccc(I)cc1Br.[Cu]I>>CCc1cc(C#Cc2ccc(F)c(Br)c2)ccc1OC(F)F",
        "output": "664"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Nc1ccc(C(=O)CCC(=O)O)cc1.O=C(Cl)C1CC1>>O=C(O)CCC(=O)c1ccc(NC(=O)C2CC2)cc1",
        "output": "9"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.C=O.CC#N.CCN(CC)CC.CI.CN(C)C=O.ClB(Cl)Cl.ClCCl.O=C([O-])[O-].Oc1cccc(F)c1O.[Cl-].[Cl-].[Cs+].[Cs+].[Mg+2]>>O=Cc1ccc(F)c(O)c1O",
        "output": "451"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCN(C(C)C)C(C)C.C[C@H](N)c1nc2ccn(C)c2cc1Br.Cc1nc(N)nc(Cl)c1C#N>>Cc1nc(N)nc(N[C@@H](C)c2nc3ccn(C)c3cc2Br)c1C#N",
        "output": "110"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCN(CCC)c1cccc2nc(Nc3ccc(Cl)cc3O)n(C)c12.CCOC(=O)/N=N/C(=O)OCC.OCCCBr.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCN(CCC)c1cccc2nc(Nc3ccc(Cl)cc3OCCCBr)n(C)c12",
        "output": "478"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CN(C(=O)O[C@H]1CCCN1C)c1ccc(F)cc1Br.Cc1cc(C)cc(B(O)O)c1.O.O=C([O-])[O-].[Na+].[Na+]>>Cc1cc(C)cc(-c2cc(F)ccc2N(C)C(=O)O[C@H]2CCCN2C)c1",
        "output": "837"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=Cc1ccc(-c2ccc(O)cc2)cc1.CC(=O)OC(C)=O.O=S(=O)(O)O>>C=Cc1ccc(-c2ccc(OC(C)=O)cc2)cc1",
        "output": "46"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc(Cl)cc1Br.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>Clc1ccc(CBr)c(Br)c1",
        "output": "29"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCC.Cc1ccccc1.N#Cc1ccc(C(=O)Cl)cc1.O.[Al+3].[Cl-].[Cl-].[Cl-]>>Cc1ccc(C(=O)c2ccc(C#N)cc2)cc1",
        "output": "61"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)C=O.NC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C1.[Na+]>>CC(C)(C)CNC1CN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)C1",
        "output": "426"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.C[C@@](CCn1cc(-c2ccc(-c3ncco3)cc2)cn1)(C(=O)NOC1CCCCO1)S(C)(=O)=O.Cl>>C[C@@](CCn1cc(-c2ccc(-c3ncco3)cc2)cn1)(C(=O)NO)S(C)(=O)=O",
        "output": "915"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(=O)c1c(C(C)C)nc2ccc(Cl)cc2c1Cc1ccccc1Cl.[Na+].[OH-]>>CC(C)c1nc2ccc(Cl)cc2c(Cc2ccccc2Cl)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrBr.CC(=O)c1cc(=O)c2cc(Br)ccc2o1.ClC(Cl)Cl>>O=C(CBr)c1cc(=O)c2cc(Br)ccc2o1",
        "output": "173"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1cc(NC(=O)Oc2ccccc2)c(OC)nc1C.Clc1cc(Cl)c(N2CCNCC2)c(Cl)c1>>CCc1cc(NC(=O)N2CCN(c3c(Cl)cc(Cl)cc3Cl)CC2)c(OC)nc1C",
        "output": "525"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)C1CCCN(C(=O)c2ccccc2)C1.Cl.[Na+].[OH-]>>O=C(O)C1CCCN(C(=O)c2ccccc2)C1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.CCC[C@H]1CC(=O)C=C2CCc3cc(OC)ccc3[C@@]21C>>CCC[C@H]1CC(=O)C=C2CCc3cc(O)ccc3[C@@]21C",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Oc2c(Cl)cc3cnccc3c2Cl)CC1.ClCCl.O=C(O)C(F)(F)F>>Clc1cc2cnccc2c(Cl)c1OC1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)(O)c1cc(Cc2ccc(Cl)cc2)nc(Cl)n1.CCN(C(C)C)C(C)C.CN1CCCC1=O.Cc1cc(N2CCC(N)CC2)ncn1.Cl.Cl.O>>Cc1cc(N2CCC(Nc3nc(Cc4ccc(Cl)cc4)cc(C(C)(C)O)n3)CC2)ncn1",
        "output": "544"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)c1ccc(C=O)cc1.ClCCl.[Br-].[Br-].[Br-].c1cc[nH+]cc1.c1cc[nH+]cc1.c1cc[nH+]cc1>>CN(C)c1ccc(C=O)cc1Br",
        "output": "784"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccc(CO[Si](C)(C)C(C)(C)C)c(F)c1F.Cl.O.[F-]>>Cc1ccc(CO)c(F)c1F",
        "output": "708"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(C#N)c(Br)c(C#N)c1O.COc1cc(C#N)c(Cc2cc(C)cc(F)c2)c(C#N)c1O.Cc1cc(F)cc(CB2OC(C)(C)C(C)(C)O2)c1>>Cc1cc(F)cc(Cc2c(C#N)cc(O)c(O)c2C#N)c1",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cccc(Oc2ccc3sc(-c4ccnc(N)n4)c(C)c3c2)c1.COc1cncc(Nc2ccc3sc(-c4ccnc(N)n4)c(C)c3c2)c1.Cc1c(-c2ccnc(N)n2)sc2ccc(Oc3cccc(O)c3)cc12>>Cc1c(-c2ccnc(N)n2)sc2ccc(Nc3cncc(O)c3)cc12",
        "output": "424"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Nc1ccc(Nc2ccnc3[nH]cc(Cl)c23)c(F)c1.Nc1nc(Cl)cc(Cl)n1.O.[Na+].[OH-]>>Nc1nc(Cl)cc(Nc2ccc(Nc3ccnc4[nH]cc(Cl)c34)c(F)c2)n1",
        "output": "161"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)C.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(OCC(F)(F)F)cc3C(F)(F)F)CN2)CC1.O=C(O)C1(C(F)(F)F)CC1>>N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(OCC(F)(F)F)cc3C(F)(F)F)CN2C(=O)C2(C(F)(F)F)CC2)CC1",
        "output": "297"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O=C[O-].[NH4+].[OH-].[OH-].[Pd+2].c1ccc(CN2CCNC[C@@H]2CCc2cccc3ccccc23)cc1>>c1ccc2c(CC[C@H]3CNCCN3)cccc2c1",
        "output": "84"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=O.CC(=O)O.CC(Cl)Cl.Cl.O=[N+]([O-])c1ccc2c(c1)CNCC2.[BH3-]C#N.[Na+].[Na+].[OH-]>>CN1CCc2ccc([N+](=O)[O-])cc2C1",
        "output": "69"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCCCCCCCCCOC(=O)c1ccc([N+](=O)[O-])cc1.CCOC(C)=O.ClCCl.[Pt]>>CCCCCCCCCCCCCCOC(=O)c1ccc(N)cc1",
        "output": "772"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCn1cc(Cl)c(C(=O)O)n1.Nc1cccc(C(=O)c2ccc3c(c2)NC(=O)C3)c1.O=S(Cl)Cl>>CCn1cc(Cl)c(C(=O)Nc2cccc(C(=O)c3ccc4c(c3)NC(=O)C4)c2)n1",
        "output": "844"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CC1CC1(NC(=O)C1CC(O)CN1)C(=O)OCC.CC(C)(C)[Si](C)(C)Cl.ClCCl.c1c[nH]cn1>>C=CC1CC1(NC(=O)C1CC(O[Si](C)(C)C(C)(C)C)CN1)C(=O)OCC",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCN1CC(CCc2cc(F)ccc2S(=O)(=O)Nc2ccc3c(c2C(=O)OC)OCC2CC32)C1.CO.O.O.O=CO.[Li+].[OH-]>>CCN1CC(CCc2cc(F)ccc2S(=O)(=O)Nc2ccc3c(c2C(=O)O)OCC2CC32)C1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCN(CC)CC.CN(C)C(=O)CCl.Cn1c(-c2cccc(N3CCCNCC3)c2)nc2ccccc21>>CN(C)C(=O)CN1CCCN(c2cccc(-c3nc4ccccc4n3C)c2)CC1",
        "output": "340"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(N)c1.CN1CCCC1=O.O=[N+]([O-])c1cc(Br)ccc1F>>CC(C)(C)OC(=O)Nc1cccc(Nc2ccc(Br)cc2[N+](=O)[O-])c1",
        "output": "609"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc(C2(C#N)CC2)c1.O>>N#CC1(c2cccc(C(=O)O)c2)CC1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.CO.CO.COC(=O)c1cc(F)c(Cl)nc1Cl.C[O-].O.[Na+]>>COC(=O)c1cc(F)c(OC)nc1Cl",
        "output": "433"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Cl.Cl[Sn]Cl.O.O.O=[N+]([O-])c1ccccc1SC(F)(F)F>>Nc1ccccc1SC(F)(F)F",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CC(=O)N2CCCCC2)c1=O.NCCN1CCOCC1>>O=C(NCCN1CCOCC1)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CC(=O)N2CCCCC2)c1=O",
        "output": "498"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cc1nc(COC)oc1C1CC1.Cl.[K+].[OH-]>>COCc1nc(CC(=O)O)c(C2CC2)o1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)CC(c2cccc(N3CCCC3)c2)Nc2c(C(=O)O)cc(Cl)cc21.CN(C)c1ccncc1.ClCCl.NS(=O)(=O)C1CC1>>CC1(C)CC(c2cccc(N3CCCC3)c2)Nc2c(C(=O)NS(=O)(=O)C3CC3)cc(Cl)cc21",
        "output": "580"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COC(=O)C(C(=O)OC)c1ccc(Br)cc1[N+](=O)[O-].COc1ccc(B(O)O)cc1.Cc1ccccc1.ClCCl.Cl[Pd]Cl.O=C([O-])[O-].[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COC(=O)C(C(=O)OC)c1ccc(-c2ccc(OC)cc2)cc1[N+](=O)[O-]",
        "output": "837"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NCCOc1cc(C#N)ccc1CO.ClCCl.[Mn+4].[O-2].[O-2]>>CC(C)(C)OC(=O)NCCOc1cc(C#N)ccc1C=O",
        "output": "179"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC(C)CCNCc1c(F)cc(Br)cc1F.CCOC(C)=O.O.O=C([O-])[O-].[K+].[K+]>>CC(C)CCN(Cc1c(F)cc(Br)cc1F)C(=O)OC(C)(C)C",
        "output": "867"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(C(F)(F)F)cc1N.Cc1cc(C2CC2)ncc1-c1cccc(C(=O)CC(=O)OC(C)(C)C)c1>>Cc1cc(C2CC2)ncc1-c1cccc(C(=O)CC(=O)Nc2cc(C(F)(F)F)ccc2NC(=O)OC(C)(C)C)c1",
        "output": "929"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COCCOC.Cc1nc(-c2ccncc2)c(Br)s1.O=C(OO)c1cccc(Cl)c1>>Cc1nc(-c2cc[n+]([O-])cc2)c(Br)s1",
        "output": "262"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CC1)CC2CN.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.O=C(O)c1cc2ccncc2o1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N1CCC2(CC1)CC2CNC(=O)c1cc2ccncc2o1",
        "output": "714"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COC(=O)CC(CCc1ccccc1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1.[Li+].[OH-]>>O=C(O)CC(CCc1ccccc1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)NC(Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.N=C(N)NCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C(N)Cc1ccccc1)C(=O)CCl.O=C(O)C(F)(F)F.O=C([O-])C(F)(F)F.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CC(=O)NC(Cc1ccc(N(CCCl)CCCl)cc1)C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(=N)N)C(=O)CCl",
        "output": "133"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(N=C=O)cc1.Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1>>Cc1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1",
        "output": "473"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C(O)c1c(Cl)cccc1Cl.O=S(=O)(O)O.O=[N+]([O-])O>>O=C(O)c1c(Cl)ccc([N+](=O)[O-])c1Cl",
        "output": "21"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1.Cl.[Na+].[OH-]>>Nc1nc(C(=O)O)nc2c1[nH]c(=O)n2Cc1ccccc1",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.CCO.O=Cc1ccccc1.[BH3-]C#N.[Na+]>>CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1",
        "output": "359"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1cn(C)c2c(C(=O)O)cc(Br)cc12.COCCOC.Cc1ccc(B(O)O)cn1.ClCCl.Cl[Pd]Cl.O.O=C([O-])O.O=C([O-])[O-].[Fe+2].[K+].[K+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1ccc(-c2cc(C(=O)O)c3c(c2)c(C(C)C)cn3C)cn1",
        "output": "899"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc(C(=O)O)ccc1Cc1c(Cl)n(C)c2ccc(CCNC(=O)N(C)C)cc12.NS(=O)(=O)c1ccccc1Cl>>COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cc1c(Cl)n(C)c2ccc(CCNC(=O)N(C)C)cc12",
        "output": "579"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CC1.CN(C)C=O.O.OCc1ccc2occc2c1.[H-].[Na+]>>c1cc2cc(COCC3CC3)ccc2o1",
        "output": "95"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)c1ccc(-c2ccc(OC)cc2)cc1F.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[Li+].[NH4+]>>COc1ccc(-c2ccc(CO)c(F)c2)cc1",
        "output": "444"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CC(C)(C)[Si](C)(C)Oc1ccc(Cl)c(Br)c1.C[C@@H](N)c1ccc(Cl)cc1Cl.Cc1ccccc1.[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>C[C@@H](Nc1cc(O[Si](C)(C)C(C)(C)C)ccc1Cl)c1ccc(Cl)cc1Cl",
        "output": "932"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O.CCOC(C)=O.CN(C)CCN.COC(=O)CCn1c(-c2ccccc2C=O)c(C2CCCCC2)c2ccc(C(=O)OC)cc21.[BH3-]C#N.[Na+]>>COC(=O)CCn1c(-c2ccccc2CNCCN(C)C)c(C2CCCCC2)c2ccc(C(=O)OC)cc21",
        "output": "468"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1cccc(N2CCOCC2)c1CC=O.ClCCl.NC(=O)c1ccc2ccn(C3CCNCC3)c2c1.[Na+].[Na+].[OH-]>>COc1cccc(N2CCOCC2)c1CCN1CCC(n2ccc3ccc(C(N)=O)cc32)CC1",
        "output": "484"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(=O)Cl.COc1cc(OCC2CC2)c(-c2ccnc3c(C(=O)N[C@H]4CC[C@@H](N)CC4)c(C)[nH]c23)cc1F.Cl>>CCC(=O)N[C@H]1CC[C@@H](NC(=O)c2c(C)[nH]c3c(-c4cc(F)c(OC)cc4OCC4CC4)ccnc23)CC1",
        "output": "45"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCCOc1ccccc1.NCCO>>OCCNCCOc1ccccc1",
        "output": "147"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)Cc1cc2ccc(F)cc2c(-c2ccc(NS(=O)(=O)c3ccccc3)cc2)c1C.O.O.[Li+].[Na+].[OH-].[OH-]>>Cc1c(CC(=O)O)cc2ccc(F)cc2c1-c1ccc(NS(=O)(=O)c2ccccc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCNc1nc(SC)ncc1C(=O)OCC.CCO.[Na+].[OH-]>>CCNc1nc(SC)ncc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.Nc1ccc(Cl)c(Br)n1>>CC(C)(C)OC(=O)Nc1ccc(Cl)c(Br)n1",
        "output": "849"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1=CCCCC1.CC(C)(C)OC(=O)N1CCC(N[C@H]2CCCC[C@@H]2OCc2ccccc2)CC1.CCO.[OH-].[OH-].[Pd+2]>>CC(C)(C)OC(=O)N1CCC(N[C@H]2CCCC[C@@H]2O)CC1",
        "output": "178"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrBr.CCOCC.Cc1c(O)ccc(O)c1C>>Cc1c(O)cc(Br)c(O)c1C",
        "output": "98"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)CC(C)=O.CC(=O)O.CCN.COC(=O)CC[C@H](N)C(=O)O.Cc1ccccc1>>CCNC(=O)CC[C@H](N)C(=O)O",
        "output": "392"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.COCCO.O=C([O-])[O-].O=[N+]([O-])c1cnc(Cl)c(Br)c1.[K+].[K+]>>COCCOc1ncc([N+](=O)[O-])cc1Br",
        "output": "433"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCNCC1.CCO.Cc1[nH]c(C=O)c(C)c1C(=O)O.O=C1Cc2ccc(NC(=O)c3ccccc3)cc2N1>>Cc1[nH]c(C=C2C(=O)Nc3cc(NC(=O)c4ccccc4)ccc32)c(C)c1C(=O)O",
        "output": "440"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCNC(=O)C(C)N1CCNCC1.COc1cc(C=CC(=O)Cl)cc(OC)c1OC.ClC(Cl)Cl>>CCNC(=O)C(C)N1CCN(C(=O)C=Cc2cc(OC)c(OC)c(OC)c2)CC1",
        "output": "135"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Clc1cccc(N2CCNCC2)c1Cl.O=C1c2ccccc2C(=O)N1CCC1CO1>>O=C1c2ccccc2C(=O)N1CCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1",
        "output": "76"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)Cn1cc(-c2oc3cc(OC)ccc3c2C(=O)c2cc(OC)c(OC)c(OC)c2)cn1.N>>COc1ccc2c(C(=O)c3cc(OC)c(OC)c(OC)c3)c(-c3cnn(CC(N)=O)c3)oc2c1",
        "output": "163"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O.CCCC[N+](CCCC)(CCCC)CCCC.C[Si](C)(C)C#Cc1ccccc1C1(C(N)=O)CC1.ClCCl.O.[F-]>>C#Cc1ccccc1C1(C(N)=O)CC1",
        "output": "337"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=[N+]=[N-].CC(=O)O.CC(C)(O)[C@H]1C(=O)N[C@@H]1CC(=O)O.CCOCC.CO>>COC(=O)C[C@H]1NC(=O)[C@@H]1C(C)(C)O",
        "output": "195"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)CCCC(O)C(CCc1ccccc1)S(=O)(=O)c1ccccc1.O=C([O-])[O-].[Na+].[Na+]>>O=C(O)CCCC(O)C(CCc1ccccc1)S(=O)(=O)c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NCCc1ccc(O)cc1.O>>CC(C)(C)OC(=O)NCCc1ccc(O)cc1",
        "output": "631"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC[O-].COc1ncncc1NC(=S)NC(=O)c1ccccc1.Cl.[Na+]>>COc1ncncc1NC(N)=S",
        "output": "80"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cccc(C(=O)Cl)c1.O=c1cc(CNc2cccc(Cl)c2)c2cccc(F)c2[nH]1>>Cc1cccc(C(=O)N(Cc2cc(=O)[nH]c3c(F)cccc23)c2cccc(Cl)c2)c1",
        "output": "614"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCCCc1nc(C(O)CCC)c(C(N)=O)n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.Cl>>CCCCc1nc(C(O)CCC)c(C(N)=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.O=C(O)c1ccc(I)cc1Cl.O=S(Cl)Cl.c1ccccc1>>O=C(Cl)c1ccc(I)cc1Cl",
        "output": "3"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.COCCc1nc2c(N)nc3ccccc3c2n1CCOCCN.ClCCl.O=C(Cl)N1CCOCC1>>COCCc1nc2c(N)nc3ccccc3c2n1CCOCCNC(=O)N1CCOCC1",
        "output": "454"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.ClCCl.O=C([O-])O.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O[C@@H]1CCCC[C@H]1c1ccccc1.[Na+].[Sn+2]>>CC(=O)O[C@@H]1CCCC[C@H]1c1ccccc1",
        "output": "254"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CC=O.O=[N+]([O-])c1ccc2c(c1)C1CNCC2O1.[Na+]>>CCN1CC2OC(C1)c1cc([N+](=O)[O-])ccc12",
        "output": "484"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.O=C([O-])[O-].O=C1CCc2c(O)cccc21.[K+].[K+]>>COc1cccc2c1CCC2=O",
        "output": "62"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC2CCC(C1)N2.CCOC(C)=O.CN(C)C=O.Clc1cccnc1Br.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CC2CCC(C1)N2c1ncccc1Cl",
        "output": "647"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC1CCNCC1.Cc1c(-c2ccc(C(=O)O)s2)noc1C(F)(F)F>>COC1CCN(C(=O)c2ccc(-c3noc(C(F)(F)F)c3C)s2)CC1",
        "output": "857"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)C(=O)Cl.COC(=O)c1ccnc(N)c1.Cl>>COC(=O)c1ccnc(NC(=O)C(C)(C)C)c1",
        "output": "332"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.C[C@@H]1CC[C@@]2(OC1)O[C@H]1C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O[Si](C)(C)C(C)(C)C)CC[C@]5(C)[C@H]4[C@@H](O)[C@@H](O)[C@]3(C)[C@H]1[C@@H]2C.ClCCl.c1ccncc1>>CC(=O)O[C@@H]1[C@H](O)[C@H]2[C@@H](CC[C@H]3C[C@@H](O[Si](C)(C)C(C)(C)C)CC[C@@]32C)[C@@H]2C[C@@H]3O[C@]4(CC[C@@H](C)CO4)[C@@H](C)[C@@H]3[C@@]12C",
        "output": "254"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)N1C(=O)C=C(c2cccc(-n3cc(-c4ccc(Cl)cc4Cl)nc3Cc3ccc(Br)cc3)c2)S1(=O)=O.OB(O)c1ccc(OCC2CCCCC2)cc1>>CC(C)(C)N1C(=O)C=C(c2cccc(-n3cc(-c4ccc(Cl)cc4Cl)nc3Cc3ccc(-c4ccc(OCC5CCCCC5)cc4)cc3)c2)S1(=O)=O",
        "output": "837"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCc1cc(Br)cc(C(=O)O)c1N.CN1CCCC1=O.N#C[Cu].[C-]#N.[Na+]>>CCc1cc(C#N)cc(C(=O)O)c1N",
        "output": "531"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.CC(N)c1ccc(Br)nc1>>CC(=O)NC(C)c1ccc(Br)nc1",
        "output": "339"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCOc1ccc(O[C@@H]2CCNC2=O)cn1.CNCCNC.O=C1CCc2c(F)cc(Br)cc21>>CCOc1ccc(O[C@@H]2CCN(c3cc(F)c4c(c3)C(=O)CC4)C2=O)cn1",
        "output": "809"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=C(Cl)CCl>>O=C(CCl)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "9"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.CNC.Cl.O.O.O=C(O)c1ccnc(Cl)c1.On1nnc2ccccc21>>CN(C)C(=O)c1ccnc(Cl)c1",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1[nH]c2c(c1C(=O)O)CCCC2=O.NCCN1CCCCC1>>Cc1[nH]c2c(c1C(=O)NCCN1CCCCC1)CCCC2=O",
        "output": "674"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)COC(=O)Cl.CN.CN(C)C=O.CN(C)c1ccncc1.CN1CCOCC1.Cc1ccc(C(=O)O)cc1-n1c(C)cc(OCc2ccc(F)cc2CNC(=O)NC2CC2)cc1=O>>CNC(=O)c1ccc(C)c(-n2c(C)cc(OCc3ccc(F)cc3CNC(=O)NC3CC3)cc2=O)c1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3C#N)cc2)C1=O.CCO.N.[Ni]>>CC(C)(C)OC(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CN)cc2)C1=O",
        "output": "175"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCC(=O)Cl.Nc1n[nH]c2ccc(C(F)(F)F)cc12.c1ccncc1>>CCCC(=O)Nc1n[nH]c2ccc(C(F)(F)F)cc12",
        "output": "527"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.O=P([O-])([O-])[O-].O=c1n(Cc2ccc(C(F)(F)F)nc2)nc2cc(-c3ccc(Cl)cc3)c(Cl)nn12.OB(O)c1ccc(Cl)cc1.[K+].[K+].[K+]>>O=c1n(Cc2ccc(C(F)(F)F)nc2)nc2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3)nn12",
        "output": "866"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.CN(C)C=O.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C.F[P-](F)(F)(F)(F)F.NN1CCCCC1.O.O=C([O-])O.[Na+]>>COc1cc(C(=O)NN2CCCCC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "55"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CS(=O)(=O)c1ncc(C#Cc2ccccc2)cn1.OC1CCC(O)CC1>>OC1CCC(Oc2ncc(C#Cc3ccccc3)cn2)CC1",
        "output": "667"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)c1ccncc1.COCCOc1cc(N)cc([N+](=O)[O-])c1>>COCCOc1cc(NC(=O)OC(C)(C)C)cc([N+](=O)[O-])c1",
        "output": "735"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.CCOCC.Cc1cccc(C)c1CO.N#CC1(c2cccc(O)c2)CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cccc(C)c1COc1cccc(C2(C#N)CC2)c1",
        "output": "347"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)c1cc(C2CC2)c(CN2CCC(CO)(c3ccc(F)cc3)CC2)cc1F.CCOC(C)=O.CI.C[Si](C)(C)[N-][Si](C)(C)C.[Li+]>>COCC1(c2ccc(F)cc2)CCN(Cc2cc(F)c(C(=O)OC(C)(C)C)cc2C2CC2)CC1",
        "output": "140"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)[O-].CCOC(C)=O.CCc1cnc(OC2CCC(O)CC2)nc1.Clc1ccc(Cl)nn1.O.[Cl-].[K+].[Na+]>>CCc1cnc(OC2CCC(Oc3ccc(Cl)nn3)CC2)nc1",
        "output": "407"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CS(C)=O.Cc1cccc(CO)n1.Clc1cc(-c2cccnc2)c2c(n1)CCCC2.O.[H-].[Na+]>>Cc1cccc(COc2cc(-c3cccnc3)c3c(n2)CCCC3)n1",
        "output": "433"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(=O)O.CN1C(=O)CCc2cc(-c3cncc(OCCN)c3)ccc21.Cl>>CCC(=O)NCCOc1cncc(-c2ccc3c(c2)CCC(=O)N3C)c1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CN1CCCc2c1nc(N1CCNCC1)[nH]c2=O.ClC(Cl)Cl.O=C(O)C(F)(F)F.O=Cc1ncccc1Cl.[BH3-]C#N.[Na+]>>CN1CCCc2c1nc(N1CCN(Cc3ncccc3Cl)CC1)[nH]c2=O",
        "output": "829"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CO.COC(=O)CNC1=C(c2ccccc2)S(=O)(=O)N(C(C)(C)C)C1=O.Cl.O.[Li+].[OH-]>>CC(C)(C)N1C(=O)C(NCC(=O)O)=C(c2ccccc2)S1(=O)=O",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)N.ClCCl.O=[N+]([O-])c1cc(S(=O)(=O)Cl)ccc1Cl>>CC(C)NS(=O)(=O)c1ccc(Cl)c([N+](=O)[O-])c1",
        "output": "43"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(S(=O)(=O)n2c(=O)n(C(C(=O)N3CCC(NC(=O)OC(C)(C)C)CC3)c3ccccc3)c3cc(C#N)ccc32)cc1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(S(=O)(=O)n2c(=O)n(C(C(=O)N3CCC(N)CC3)c3ccccc3)c3cc(C#N)ccc32)cc1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC(=O)N(CC)c1ccc(N)c([N+](=O)[O-])c1.CCO.[Pd]>>CCN(CC)CC(=O)N(CC)c1ccc(N)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(C(CC(O[Si](C)(C)C(C)(C)C)c3c(F)cccc3F)=NO)cs2)CC1.[F-]>>Cc1cc(C(F)(F)F)nn1CC(=O)N1CCC(c2nc(C(CC(O)c3c(F)cccc3F)=NO)cs2)CC1",
        "output": "708"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CO.COCOc1ccc(/C(C(=O)Nc2ccc(OCCN(C)C)cc2)=C(\\c2ccccc2)C2CC2)cc1.Cl.O.O=C([O-])O.[Na+]>>CN(C)CCOc1ccc(NC(=O)/C(=C(/c2ccccc2)C2CC2)c2ccc(O)cc2)cc1",
        "output": "755"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccccc1.Nc1ccc(F)cc1N.O.O=C(O)CN1C(=O)C2(COc3cc4c(cc32)OCO4)c2ccccc21>>O=C1N(Cc2nc3cc(F)ccc3[nH]2)c2ccccc2C12COc1cc3c(cc12)OCO3",
        "output": "512"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(C2Cc3cc(Cl)ncc3O2)CC1.CS(=O)(=O)Cc1ccc(B(O)O)cc1>>CC(C)(C)OC(=O)N1CCC(C2Cc3cc(-c4ccc(CS(C)(=O)=O)cc4)ncc3O2)CC1",
        "output": "865"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Br.CC(=O)O.COc1ccc(CC(=O)O)c(C(F)(F)F)c1>>O=C(O)Cc1ccc(O)cc1C(F)(F)F",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1nc([C@@H]2C[C@H]2N(CC2CC2)C(=O)OC(C)(C)C)cs1.Cl.[Na+].[OH-]>>CC(C)(C)OC(=O)N(CC1CC1)[C@@H]1C[C@H]1c1csc(C(=O)O)n1",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.CC(=O)O.CC(=O)O.O=C(NCCCC[C@H](NC(=O)[C@@H]1CCCN(C(=O)CCc2ccccc2)C1)C(=O)c1nc2ccccc2s1)OCc1ccccc1>>NCCCC[C@H](NC(=O)[C@@H]1CCCN(C(=O)CCc2ccccc2)C1)C(=O)c1nc2ccccc2s1",
        "output": "574"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N[C@H]1CCC[C@@H]1N.ClCCl.O=C1CCC1.[Na+].[Na+].[OH-]>>CC(C)(C)OC(=O)N[C@H]1CCC[C@@H]1NC1CCC1",
        "output": "236"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)c1ncc2c(Oc3ccc(OC)cc3)cccc2c1O.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)c1nc(Br)c2c(Oc3ccc(OC)cc3)cccc2c1O",
        "output": "779"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CI.COCC(O)Cn1cc(-c2ccc3cnc(Cl)cc3c2)cn1.[H-].[Na+]>>COCC(Cn1cc(-c2ccc3cnc(Cl)cc3c2)cn1)OC",
        "output": "140"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCCC[C@@H]1C(=O)Nc1cc2c3c(c(-c4ccccc4)[nH]c3c1)C=NNC2=O.Cl>>O=C1NN=Cc2c(-c3ccccc3)[nH]c3cc(NC(=O)[C@H]4CCCCN4)cc1c23",
        "output": "634"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CO.Clc1c2ccccc2nc2ccccc12.Nc1ccc(CCCCCCCO)cc1>>OCCCCCCCc1ccc(Nc2c3ccccc3nc3ccccc23)cc1",
        "output": "115"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrP(Br)Br.Cc1cccc([N+](=O)[O-])c1CO.ClC(Cl)Cl.O>>Cc1cccc([N+](=O)[O-])c1CBr",
        "output": "300"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.N#Cc1c(Cl)cc(N)cc1Cl.S=C(Cl)Cl.c1ccccc1>>N#Cc1c(Cl)cc(N=C=S)cc1Cl",
        "output": "114"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)[Si](OC1CCN(C2CCN(Cc3c(Cl)cc(-c4ccc(C(=O)N5CCC(C(F)(F)F)CC5)cc4)cc3Cl)C2=O)CC1)(c1ccccc1)c1ccccc1.CCOC(C)=O.O.O=C(O)C(F)(F)F.[Na+].[OH-]>>O=C(c1ccc(-c2cc(Cl)c(CN3CCC(N4CCC(O)CC4)C3=O)c(Cl)c2)cc1)N1CCC(C(F)(F)F)CC1",
        "output": "781"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "B.C1CCOC1.C1CCOC1.O=C(OC12CCC(C(=O)O)(CC1)CC2)c1cc(F)cc(F)c1.O=C([O-])O.[Na+]>>O=C(OC12CCC(CO)(CC1)CC2)c1cc(F)cc(F)c1",
        "output": "231"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc(C#N)c(Br)c(C#N)c1O.COc1ccc2cc(-c3c(C#N)cc(OC)c(O)c3C#N)ccc2c1.COc1ccc2cc(B(O)O)ccc2c1>>N#Cc1cc(O)c(O)c(C#N)c1-c1ccc2cc(O)ccc2c1",
        "output": "20"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc2c(c1)CCNC2.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCO.Cl.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N1CCc2cc(Br)ccc2C1",
        "output": "867"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CCOc1cc(C(=O)OC)cc([N+](=O)[O-])c1.CO.O.[Pd]>>CCOc1cc(N)cc(C(=O)OC)c1",
        "output": "481"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=Cc1cc(OC)c(CCC)c(OC)c1.CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.Fc1ccc(Br)c(F)c1.O.O=C([O-])[O-].[I-].[K+].[K+]>>CCCc1c(OC)cc(C=Cc2ccc(F)cc2F)cc1OC",
        "output": "539"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.NS(=O)(=O)Cc1ccccn1.O=C(OO)c1cccc(Cl)c1>>NS(=O)(=O)Cc1cccc[n+]1[O-]",
        "output": "262"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCON=C(CN)c1ncc(C(F)(F)F)cc1Cl.ClCCl.O.O=C(Cl)c1ccccc1C(F)(F)F>>CCON=C(CNC(=O)c1ccccc1C(F)(F)F)c1ncc(C(F)(F)F)cc1Cl",
        "output": "271"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCN(c1cccc2cc(C(=O)O)[nH]c12)S(=O)(=O)c1cccs1.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.NCCSC(c1ccccc1)(c1ccccc1)c1ccccc1.O.On1nnc2ccccc21>>CCN(c1cccc2cc(C(=O)NCCSC(c3ccccc3)(c3ccccc3)c3ccccc3)[nH]c12)S(=O)(=O)c1cccs1",
        "output": "137"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CN(C)CC1CCN(C(=O)Nc2cc(Oc3ccc([N+](=O)[O-])cc3F)ncn2)CC1.[C].[OH-].[OH-].[Pd+2]>>CN(C)CC1CCN(C(=O)Nc2cc(Oc3ccc(N)cc3F)ncn2)CC1",
        "output": "335"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.N#Cc1c(Cl)ccc([N+](=O)[O-])c1N.[Pd]>>N#Cc1c(Cl)ccc(N)c1N",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)/C=C/c1cnc(Cl)cn1.CN1CCN(C)C1=O.COc1cccc(CN2CC[C@@H](N)C2)c1.Cl.Cl.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)/C=C/c1cnc(N[C@@H]2CCN(Cc3cccc(OC)c3)C2)cn1",
        "output": "148"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)CCc1ccc2c(c1)OCCn1cc(-c3nc(C)nn3C(C)C)nc1-2.[Li+].[OH-]>>Cc1nc(-c2cn3c(n2)-c2ccc(CCC(=O)O)cc2OCC3)n(C(C)C)n1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COc1ccc(CNc2cc(Nc3cnc(C#N)cn3)ncc2[N+](=O)[O-])cc1.Cl[Sn]Cl.O.O>>COc1ccc(CNc2cc(Nc3cnc(C#N)cn3)ncc2N)cc1",
        "output": "269"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)OC(C)=O.CC(C)CN([C@H](CO)CCCCNC(=O)OC(C)(C)C)S(=O)(=O)c1ccc(NC(=O)OC(C)(C)C)cc1.ClCCl>>CC(=O)OC[C@H](CCCCNC(=O)OC(C)(C)C)N(CC(C)C)S(=O)(=O)c1ccc(NC(=O)OC(C)(C)C)cc1",
        "output": "254"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(=O)CC1.CSc1ccc(N)cc1C(F)(F)F.ClCCl.[Na+]>>CSc1ccc(NC2CCN(C(=O)OC(C)(C)C)CC2)cc1C(F)(F)F",
        "output": "469"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.CN.CN(C)C=O.Cl.ClCCl.O.O=C(Cl)C(=O)Cl.O=C(O)c1cc(Br)cc([N+](=O)[O-])c1>>CNC(=O)c1cc(Br)cc([N+](=O)[O-])c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.COc1ccc(C(=O)Cl)cc1.Cn1nnnc1SCCCN.O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(C(=O)NCCCSc2nnnn2C)cc1",
        "output": "271"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)Cc1c(Cl)nc(C)nc1Cl.CS(C)=O.Cc1cc(C)c(N)c(C)c1>>CCOC(=O)Cc1c(Cl)nc(C)nc1Nc1c(C)cc(C)cc1C",
        "output": "161"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)C(OC(C)(C)C)c1c(-c2ccc3c(c2C)CCCO3)c2c3c(sc2c(=O)n1C)CCCC3.Cl.O.O.[Li+].[OH-]>>Cc1c(-c2c(C(OC(C)(C)C)C(=O)O)n(C)c(=O)c3sc4c(c23)CCCC4)ccc2c1CCCO2",
        "output": "88"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)CC(=O)O.CS(C)=O.FC(F)(F)c1n[nH]c2c1COCC2.O=C([O-])[O-].O=S(=O)(NCC1CCCO1)c1ccc(I)cc1.[Cu]I.[K+].[K+]>>O=S(=O)(NCC1CCCO1)c1ccc(-n2nc(C(F)(F)F)c3c2CCOC3)cc1",
        "output": "901"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCC(CC(=O)O)CC1.ClCCCl.Nc1ccc(Br)cc1O>>CC(C)(C)OC(=O)N1CCC(CC(=O)Nc2ccc(Br)cc2O)CC1",
        "output": "365"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)CCc1ccc2cccc(N3CCN(C(=O)OC(C)(C)C)CC3)c2n1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)CCc1ccc2cccc(N3CCNCC3)c2n1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.O=C(C1CCNCC1)N(CCCN1CCC(Cc2ccccc2)CC1)c1ccccc1.O=C([O-])O.[Na+]>>CC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccccc3)CC2)c2ccccc2)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.Cl.O.O=C(OCc1ccccc1)c1cc(Cl)c(C(=O)N2CCC(F)(F)C2)cc1OCc1ccccc1.[Li+].[OH-]>>O=C(O)c1cc(Cl)c(C(=O)N2CCC(F)(F)C2)cc1OCc1ccccc1",
        "output": "290"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Clc1ncccn1.Cn1ncc2c(=O)n(CC3(O)CCN(C(=O)c4ccc(CO)cc4)CC3)cnc21.[H-].[Na+]>>Cn1ncc2c(=O)n(CC3(O)CCN(C(=O)c4ccc(COc5ncccn5)cc4)CC3)cnc21",
        "output": "37"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.N#CCCN1CCC(Nc2nccc(-c3cc4ccccc4s3)n2)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCCCN1CCC(Nc2nccc(-c3cc4ccccc4s3)n2)CC1",
        "output": "246"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(NCC(=O)OCc2ccccc2)CC1.CCOC(C)=O.CCOC(C)=O.CO.Cl.O=C([O-])[O-].[Na+].[Na+]>>O=C(CNC1CCNCC1)OCc1ccccc1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Clc1ccc2ncc(-c3cc4ccccc4o3)n2n1.NCCOCCO.[H-].[Na+]>>NCCOCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1",
        "output": "407"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)[C@H]1CC[C@@H](Oc2ccc(C(=O)Nc3ccc(NC4CCCC4)nn3)cc2)CC1.Cl.O.O.[Li+].[OH-]>>O=C(Nc1ccc(NC2CCCC2)nn1)c1ccc(O[C@@H]2CC[C@H](C(=O)O)CC2)cc1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.O=C(c1ccccc1)c1cc2c(cc1O)C(C(=O)O)CC2>>CC(=O)Oc1cc2c(cc1C(=O)c1ccccc1)CCC2C(=O)O",
        "output": "46"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.CCc1noc(-c2ccc(Br)cc2)c1NC(=O)O[C@H](C)c1cccc(C(F)(F)F)c1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(CC)c4NC(=O)O[C@H](C)c4cccc(C(F)(F)F)c4)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CN(C2CCOCC2)CCN1.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1cc(C[C@@H](OC(=O)N2CCC(n3nc(-c4ccccc4)[nH]c3=O)CC2)C(=O)O)cc(C)c1O.F[B-](F)(F)F>>Cc1cc(C[C@@H](OC(=O)N2CCC(n3nc(-c4ccccc4)[nH]c3=O)CC2)C(=O)N2CCN(C3CCOCC3)CC2)cc(C)c1O",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.N#CC1CN(Cc2ccccc2)CCC1O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCC1CN(Cc2ccccc2)CCC1O",
        "output": "246"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(O)C1CCNCC1.COc1cc2nncc(-c3cnc(F)c(C)c3)c2cc1OC.CS(C)=O.O>>COc1cc2nncc(-c3cnc(N4CCC(C(C)(C)O)CC4)c(C)c3)c2cc1OC",
        "output": "756"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.CCCCC1C=C(Cl)C(=O)C1=CCCCCCC(=O)OC.Cl.O=P([O-])([O-])[O-].O=S(=O)([O-])[O-].[NH4+].[NH4+]>>CCCCC1C=C(Cl)C(=O)C1=CCCCCCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCCOc1cc(CCC(=O)OCC)n(Cc2ccc(Cl)cc2Cl)n1.CCO.[Na+].[OH-]>>CCCCOc1cc(CCC(=O)O)n(Cc2ccc(Cl)cc2Cl)n1",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CSc1ccc(S(C)(=O)=O)cc1C(=O)O.Cl.FC(F)(F)c1cnc(N2CCNCC2)s1>>CSc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ncc(C(F)(F)F)s2)CC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cccc(C)n1.ClCCl.O=C(N1CCC(CCO)CC1)C(F)(F)F.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>O=C(N1CCC(CCOS(=O)(=O)C(F)(F)F)CC1)C(F)(F)F",
        "output": "582"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cn1c(S)nc2ccsc2c1=O.O.O.O=C(c1ccc(CBr)cc1)c1ccc(Cl)nc1.[Na+].[OH-]>>Cn1c(SCc2ccc(C(=O)c3ccc(Cl)nc3)cc2)nc2ccsc2c1=O",
        "output": "699"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.Cc1ccc(N)cc1NC(=O)c1ccc2ncccc2c1.O=C(Cl)c1ccc(Cl)nc1>>Cc1ccc(NC(=O)c2ccc(Cl)nc2)cc1NC(=O)c1ccc2ncccc2c1",
        "output": "642"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Cc1ccc(O)cc1.ClCCl.O.OCCCCCCCCCCCBr.[K+].[OH-]>>Cc1ccc(OCCCCCCCCCCCO)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1ccoc1Cl.[Na+].[OH-]>>O=C(O)c1ccoc1Cl",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.O.[N-]=[N+]=NCC(O)CC1c2ccccc2CCc2sccc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NCC(O)CC1c2ccccc2CCc2sccc21",
        "output": "89"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C=CC[C@@](CN(C)C(=O)CC(F)(F)F)(c1ccc(Cl)c(Cl)c1)N(C)C(=O)Oc1ccccc1.O.OO.[Na+].[OH-]>>CN(C[C@](CCCO)(c1ccc(Cl)c(Cl)c1)N(C)C(=O)Oc1ccccc1)C(=O)CC(F)(F)F",
        "output": "465"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.CC(=O)O.CN(C)C(c1ccccc1)C1CCN(C(=O)OCc2ccccc2)CC1>>CN(C)C(c1ccccc1)C1CCNCC1",
        "output": "428"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)Nc1cc(Cl)c(Cl)cc1[N+](=O)[O-].CCNC.CS(C)=O>>CCN(C)c1cc(NC(=O)OC(C)(C)C)c([N+](=O)[O-])cc1Cl",
        "output": "105"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Clc1cccc(N2CCNCC2)c1Cl.Fc1ccc2[nH]cc(CCCCl)c2c1>>Fc1ccc2[nH]cc(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2c1",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)NCCS(=O)c1ccccc1.CCN(CC)CCN.O=C(n1ccnc1)n1ccnc1>>CCN(CC)CCNC(=O)N(CCS(=O)c1ccccc1)C(C)C",
        "output": "734"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCC(=O)N(Cc1ccc(C2SC(=O)NC2=O)cc1)c1cccc(C(=O)OCC)c1.CCO.Cl.[Na+].[OH-]>>CCCCC(=O)N(Cc1ccc(C2SC(=O)NC2=O)cc1)c1cccc(C(=O)O)c1",
        "output": "5"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "NC(=O)c1cc(-c2ccsc2)cc2c(C3CCN(S(=O)(=O)CCCCl)CC3)c[nH]c12.NS(N)(=O)=O.O=C([O-])[O-].OC1CCNCC1.[K+].[K+]>>NC(=O)c1cc(-c2ccsc2)cc2c(C3CCN(S(=O)(=O)CCCN4CCC(O)CC4)CC3)c[nH]c12",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.ClC(Cl)Cl.NC(=O)Cc1cnc(Nc2ccc(N3CCCNCC3)cc2)cc1NCc1cc(F)cc(F)c1.O.O=C([O-])O.[Na+].[Na+]>>CC(C)N1CCCN(c2ccc(Nc3cc(NCc4cc(F)cc(F)c4)c(CC(N)=O)cn3)cc2)CC1",
        "output": "187"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1.ClCCCl.F[C@H]1CCN(C2CCNCC2)C1.[Na+]>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(N4CC[C@H](F)C4)CC3)n(C)c2n1",
        "output": "944"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CCc1ccc(O)c(OC)c1.CC(=O)[O-].COCCOC.Cc1ccc(S(=O)(=O)NN)cc1.O.[Na+]>>CCCc1ccc(O)c(OC)c1",
        "output": "116"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CCOC(=O)c1cn(-c2cc(N)c(F)cc2F)c2cc(F)c(F)cc2c1=O.Cl>>Nc1cc(-n2cc(C(=O)O)c(=O)c3cc(F)c(F)cc32)c(F)cc1F",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.COc1ccc(C(=O)N2CCC(N3C(=O)CCc4cc([N+](=O)[O-])ccc43)CC2)c(OC)c1.[C].[Pd]>>COc1ccc(C(=O)N2CCC(N3C(=O)CCc4cc(N)ccc43)CC2)c(OC)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCC.COc1ccc2nccc(-n3cc4c(n3)CCC(N(CC(=O)OC(C)(C)C)Cc3ccc5c(c3)NC(=O)CS5)C4)c2n1.Cl>>COc1ccc2nccc(-n3cc4c(n3)CCC(N(CC(=O)O)Cc3ccc5c(c3)NC(=O)CS5)C4)c2n1",
        "output": "278"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.COc1ccc2c(n1)[C@H](Nc1cccc(C)n1)[C@@H](C)[C@H](C1CC1)N2C(C)=O.[I-].[Na+]>>CC(=O)N1c2ccc(O)nc2[C@H](Nc2cccc(C)n2)[C@@H](C)[C@@H]1C1CC1",
        "output": "408"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC[C@@H]1Oc2cc(C(=O)OC)ccc2N(CC)C1=O.Cl>>CC[C@@H]1Oc2cc(C(=O)O)ccc2N(CC)C1=O",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CC(C)(C)OC(=O)NN(CC1CCCCC1)C[C@H](O)[C@@H](N)Cc1ccccc1.CN1CCOCC1.NC(=O)C[C@H](NC(=O)c1ccc2ccccc2n1)C(=O)O.On1nnc2ccccc21>>CC(C)(C)OC(=O)NN(CC1CCCCC1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)c2ccc(Cl)cc2)CC1.CCO.[BH4-].[Na+]>>CC(C)(C)OC(=O)N1CCC(C(O)c2ccc(Cl)cc2)CC1",
        "output": "24"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.ClCCl.Cn1nc(Nc2cc(-c3cccc(-n4ccc5cc(C(C)(C)C#N)cc(F)c5c4=O)c3C=O)nn(C)c2=O)cc1CN1CCC1.O.[BH4-].[Na+]>>Cn1nc(Nc2cc(-c3cccc(-n4ccc5cc(C(C)(C)C#N)cc(F)c5c4=O)c3CO)nn(C)c2=O)cc1CN1CCC1",
        "output": "356"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(N)CO.CC(C)Nc1cccnc1N1CCN(C(=O)c2ccc(C(=O)O)cn2)CC1>>CC(C)Nc1cccnc1N1CCN(C(=O)c2ccc(C(=O)NC(C)(C)CO)cn2)CC1",
        "output": "674"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(=O)Nc1cccc(B(O)O)c1.Cc1cc(N2CCN(C(C)C)CC2)ncc1Br.O.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CC(=O)Nc1cccc(-c2cnc(N3CCN(C(C)C)CC3)cc2C)c1",
        "output": "833"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)O.CO.C[Si](C)(C)C=[N+]=[N-].N#Cc1ccc(N2CCC(C(=O)O)CC2)cc1>>COC(=O)C1CCN(c2ccc(C#N)cc2)CC1",
        "output": "195"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)Cc1ccc(OCc2ccccc2)cc1.Cl.[Li+].[OH-]>>O=C(O)Cc1ccc(OCc2ccccc2)cc1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.O=S(=O)(O)O.O=[N+]([O-])O.c1ccc(C2CCNCC2)cc1>>O=[N+]([O-])c1ccc(C2CCNCC2)cc1",
        "output": "21"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1cccc(-c2c(C(=O)c3ccccc3)cnc3c(C(F)(F)F)cccc23)c1.O=Cc1ccc(C=C2SC(=O)NC2=O)cc1>>O=C1NC(=O)/C(=C/c2ccc(CNc3cccc(-c4c(C(=O)c5ccccc5)cnc5c(C(F)(F)F)cccc45)c3)cc2)S1",
        "output": "359"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.CCN=C=NCCCN(C)C.CN(C)C=O.COc1ccc(-c2c(Cl)c(CN3C(=O)CCC3=O)nc3sc4c(c23)CCC(C(=O)O)C4)cc1.Cl.O>>COc1ccc(-c2c(Cl)c(CN3C(=O)CCC3=O)nc3sc4c(c23)CCC(C(=O)N2CCOCC2)C4)cc1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(B3OC(C)(C)C(C)(C)O3)cc12.Cl[Pd]Cl.O.O=C([O-])[O-].O=Cc1ccc(Cl)nc1Cl.[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc(C=O)c(Cl)n3)cc12",
        "output": "955"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.C[O-].Cc1cc(F)ccc1-c1nc(S(C)(=O)=O)nc2c1CNC(=O)N2c1c(F)cccc1F.[Na+]>>COc1nc(-c2ccc(F)cc2C)c2c(n1)N(c1c(F)cccc1F)C(=O)NC2",
        "output": "667"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CCOC(C)=O.Cc1cc([N+](=O)[O-])ccc1Oc1c(C)cccc1C.[Cl-].[NH4+].[Zn]>>Cc1cc(N)ccc1Oc1c(C)cccc1C",
        "output": "335"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCc1c(Cl)ncnc1Cn1ccnc1-c1cccc(F)n1.CCN>>CCCc1c(Cn2ccnc2-c2cccc(F)n2)ncnc1NCC",
        "output": "166"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.COC(=O)[C@@H](NC(=O)c1ccc(C#CC#Cc2ccc(NS(C)(=O)=O)cc2)cc1)[C@@H](C)N.NO.O=C(O)C(F)(F)F>>C[C@@H](N)[C@H](NC(=O)c1ccc(C#CC#Cc2ccc(NS(C)(=O)=O)cc2)cc1)C(=O)NO",
        "output": "376"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CN(C)C=O.O=C(Cl)C(=O)Cl.O=C(O)Cc1ccc2c(c1)NC(=O)CO2>>O=C(Cl)Cc1ccc2c(c1)NC(=O)CO2",
        "output": "56"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1ccsc1C(=O)O.Cl.O.O=C(NCC(=O)N1CCNCC1)c1ccc(-c2ccccc2)cc1.O=C(O)C(F)(F)F.On1nnc2ccccc21>>Cc1ccsc1C(=O)N1CCN(C(=O)CNC(=O)c2ccc(-c3ccccc3)cc2)CC1",
        "output": "857"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2sc3c(c12)CCC(C(=O)O)C3.CNCC(F)F>>CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2sc3c(c12)CCC(C(=O)N(C)CC(F)F)C3",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.COc1ccccc1C=O.Cl.NO.O.[Na+].[OH-]>>COc1ccccc1C=NO",
        "output": "30"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1.Cl.Cl.ClCCCCCOc1ccccc1.O.O=C([O-])[O-].[K+].[K+]>>COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCOc2ccccc2)CC1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)C(=O)Cl.ClCCl.Cn1cc(C2CCNCC2)c2cc(NS(=O)(=O)c3ccc(F)cc3)ccc21.O.c1ccncc1>>CC(C)C(=O)N1CCC(c2cn(C)c3ccc(NS(=O)(=O)c4ccc(F)cc4)cc23)CC1",
        "output": "125"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COc1cccc(-c2c(C(=O)O)[nH]c3ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)cc23)c1.ClCCl.NCCO>>COc1cccc(-c2c(C(=O)NCCO)[nH]c3ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)cc23)c1",
        "output": "137"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#CC(C)(C)C.CCN(CC)CC.Cl[Pd]Cl.O=C(O)c1ccc(Cl)nc1Cl.[Cu]I.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)C#Cc1ccc(C(=O)O)c(Cl)n1",
        "output": "818"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)c1cc(OCCCOC2CCCCO2)cc(C(=O)O)c1.CCN(C(C)C)C(C)C.CCOC(=O)C(C#N)=NOC(N(C)C)=[N+](C)C.CN(C)C=O.CNOC.Cl.F[B-](F)(F)F>>CON(C)C(=O)c1cc(OCCCOC2CCCCO2)cc(C(C)(C)C)c1",
        "output": "828"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrC(Br)(Br)Br.ClCCl.O=C1CCCN1Cc1nc(N2CCC(CO)CC2)c2c(-c3ccccc3)csc2n1>>O=C1CCCN1Cc1nc(N2CCC(CBr)CC2)c2c(-c3ccccc3)csc2n1",
        "output": "378"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C1COCCO1.CCOC(=O)c1cnc(N2CC(NC(=O)OC(C)(C)C)C2)s1.CCOC(C)=O.CO.Cl>>CCOC(=O)c1cnc(N2CC(N)C2)s1",
        "output": "538"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCI.O=[N+]([O-])c1ccc2[nH]ccc2c1>>CCCn1ccc2cc([N+](=O)[O-])ccc21",
        "output": "302"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClC(Cl)Cl.N#Cc1ccc(C#Cc2ccc(C=O)cc2)cc1.[Na+]>>N#Cc1ccc(C#Cc2ccc(CN3CCOCC3)cc2)cc1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.Cl.O=C(NC1CCNCC1)c1c[nH]c2c(-c3c(OCC4CC4)ccc4c3OCO4)ncnc12>>CC(=O)N1CCC(NC(=O)c2c[nH]c3c(-c4c(OCC5CC5)ccc5c4OCO5)ncnc23)CC1",
        "output": "125"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)Cc1cccc2nccnc12.Cl>>O=C(O)Cc1cccc2nccnc12",
        "output": "278"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCCBr.CCOC(=O)/C(=N\\OCCBr)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1.CN(C)C=O.[N-]=[N+]=[N-].[Na+]>>CCOC(=O)/C(=N\\OCCN=[N+]=[N-])c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1",
        "output": "622"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CN(C)C(=O)Cl.COC(=O)[C@H](Cc1ccc(OCc2ccccc2)c(O)c1)NC(=O)OC(C)(C)C.ClCCl>>COC(=O)[C@H](Cc1ccc(OCc2ccccc2)c(OC(=O)N(C)C)c1)NC(=O)OC(C)(C)C",
        "output": "425"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(Sc1ccc2nc(N)sc2c1)C(=O)N1CCCC1.CO>>CC(C)(CN1CCCC1)Sc1ccc2nc(N)sc2c1",
        "output": "112"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=C1CC[C@H]2[C@H](CN)[C@@H]([C@@]3(C)CC[C@H](O)C[C@@H]3CO)CC[C@]12C.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Cc1ccc(C(=O)O)cc1.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>C=C1CC[C@H]2[C@H](CNC(=O)c3ccc(C)cc3)[C@@H]([C@@]3(C)CC[C@H](O)C[C@@H]3CO)CC[C@]12C",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C(=O)Cl)CCCCC1.CCN(CC)CC.COc1ccccc1N1CCN(C[C@H](N)Cc2ccncc2)CC1.ClCCl>>COc1ccccc1N1CCN(C[C@@H](Cc2ccncc2)NC(=O)C2(C)CCCCC2)CC1",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(CC=O)ccn34)c12.CN1CCNCC1.ClCCl.[Na+]>>CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(CCN5CCN(C)CC5)ccn34)c12",
        "output": "484"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COC(=O)c1ccc2c(c1)-n1nc(-c3ncnn3CC(F)(F)F)cc1CCO2.O.[Li+].[OH-]>>O=C(O)c1ccc2c(c1)-n1nc(-c3ncnn3CC(F)(F)F)cc1CCO2",
        "output": "222"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "O=C(NC[C@H]1NC[C@H]2C[C@H]21)c1cccc2occc12.O=C(O)c1cccc2c1-c1ccccc1C2>>O=C(NC[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)c1cccc2c1-c1ccccc1C2)c1cccc2occc12",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Nc1cccc(C(F)(F)F)c1.O=C(O)c1ccc([N+](=O)[O-])cc1>>O=C(Nc1cccc(C(F)(F)F)c1)c1ccc([N+](=O)[O-])cc1",
        "output": "50"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cc1nc(-n2cccc2)c(C)c(C)c1OCc1ccccc1.[Pd]>>Cc1nc(-n2cccc2)c(C)c(C)c1O",
        "output": "264"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COc1ccc(F)c(-c2ccc(CO)cc2C(=O)C(C)(C)C)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>COc1ccc(F)c(-c2ccc(CO)cc2C(O)C(C)(C)C)c1",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cc(C)nc(CO)c1.ClC(Cl)Cl.[Mn+4].[O-2].[O-2]>>Cc1cc(C)nc(C=O)c1",
        "output": "263"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(C)[C@H](C=C(Cl)Cl)[C@@H]1C(=O)Cl.ClCCl.OCc1cccc(-c2ccsc2)c1.c1ccncc1>>CC1(C)[C@H](C=C(Cl)Cl)[C@@H]1C(=O)OCc1cccc(-c2ccsc2)c1",
        "output": "126"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1cccc(S(N)(=O)=O)c1.O=C(O)c1cnn2c(C3CC3)cc(-c3ccc(Cl)cc3)nc12>>NS(=O)(=O)c1cccc(NC(=O)c2cnn3c(C4CC4)cc(-c4ccc(Cl)cc4)nc23)c1",
        "output": "969"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cl[Pd]Cl.Fc1cc(Br)cc(Cl)c1Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2cc(F)c(Cl)c(Cl)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)CC(C)C.CS(=O)(=O)O.O=C([O-])[O-].O=c1[nH]c2cc(Cl)ccc2n1CCCO.OC1(c2ccc(Cl)cc2)CCNCC1.[Na+].[Na+]>>O=c1[nH]c2cc(Cl)ccc2n1CCCN1CCC(O)(c2ccc(Cl)cc2)CC1",
        "output": "371"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(O)CN.O=C(N[C@H]1CC[C@@H](C(=O)O)C1)c1ccc(-c2cccc(F)c2)nc1>>CC(C)(O)CNC(=O)[C@@H]1CC[C@H](NC(=O)c2ccc(-c3cccc(F)c3)nc2)C1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)NCCCN.Cc1ccc(C(=O)Nc2ccc(F)cc2)cc1-c1nc(S(C)=O)nc2c1CNC(=O)N2c1c(F)cccc1F>>Cc1ccc(C(=O)Nc2ccc(F)cc2)cc1-c1nc(NCCCNC(C)C)nc2c1CNC(=O)N2c1c(F)cccc1F",
        "output": "666"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.CN(C)C=O.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C.F[P-](F)(F)(F)(F)F.NCCN1CCCCC1.O.O=C([O-])O.[Na+]>>COc1cc(C(=O)NCCN2CCCCC2)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CNCc1ccco1.O=C1CCc2cc(F)ccc21>>CN(Cc1ccco1)c1ccc2c(c1)CCC2=O",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1c2n(c3c(Br)cc(Cl)cc13)CCNC2=O.OB(O)c1cccc(F)c1>>Cc1c2n(c3c(-c4cccc(F)c4)cc(Cl)cc13)CCNC2=O",
        "output": "833"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.Nc1cc(-c2ccccc2)nn1-c1ccccc1.O=C1CCC(=O)N1Cl>>Nc1c(Cl)c(-c2ccccc2)nn1-c1ccccc1",
        "output": "856"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.COc1c(C(=O)NCC(C)O)ccc2[nH]nc(/C=C/c3ccc(F)cc3)c12.CS(C)=O.ClCCl.O>>COc1c(C(=O)NCC(C)=O)ccc2[nH]nc(/C=C/c3ccc(F)cc3)c12",
        "output": "87"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCl.Cn1cc(-n2ccc(=O)c(C(=O)OC(C)(C)C)n2)cn1.O=C(O)C(F)(F)F>>Cn1cc(-n2ccc(=O)c(C(=O)O)n2)cn1",
        "output": "569"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OC(C)=O.CN(CCCOc1nsc(-c2ccccc2)n1)CCc1ccc(N)cc1.O=C([O-])[O-].[Na+].[Na+].c1ccncc1>>CC(=O)Nc1ccc(CCN(C)CCCOc2nsc(-c3ccccc3)n2)cc1",
        "output": "6"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CO.COc1c(C(C)=O)cc(C)c(C#N)c1C1CN(C(=O)OC(C)(C)C)C1.O.[BH4-].[Na+]>>COc1c(C(C)O)cc(C)c(C#N)c1C1CN(C(=O)OC(C)(C)C)C1",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.COC(=O)c1ccnc2cc(CC3CCCCC3)[nH]c12.O>>O=C(O)c1ccnc2cc(CC3CCCCC3)[nH]c12",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CCc1cccc(CCc2nc(-c3ccccc3)c(-c3ccccc3)o2)c1.CO.[Na+].[OH-]>>O=C(O)CCc1cccc(CCc2nc(-c3ccccc3)c(-c3ccccc3)o2)c1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCNc1c(Br)cncc1[N+](=O)[O-].CCOC(C)=O.ClCCl.[Fe]>>CCNc1c(N)cncc1Br",
        "output": "269"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1Oc2c(cc(C=O)cc2OC(F)F)NC1=O.CNC(=O)c1ccc(N2CCNCC2)c(C)c1>>CNC(=O)c1ccc(N2CCN(Cc3cc4c(c(OC(F)F)c3)OC(C)C(=O)N4)CC2)c(C)c1",
        "output": "567"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)CC1CCN(C(=O)CN2CC(c3ccccc3Cl)c3cc(C)ccc3C(CC(C)C)C2=O)CC1.CO.Cl.O.[Na+].[OH-]>>Cc1ccc2c(c1)C(c1ccccc1Cl)CN(CC(=O)N1CCC(CC(=O)O)CC1)C(=O)C2CC(C)C",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "B.C1CCOC1.C1CCOC1.COc1ccccc1N1CCN(CCC(N)=O)CC1.Cl.[Na+].[OH-]>>COc1ccccc1N1CCN(CCCN)CC1",
        "output": "112"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CI.CN(C)C=O.Cc1ccccc1C(=O)O.O.O=C([O-])O.[Na+]>>COC(=O)c1ccccc1C",
        "output": "415"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O.O=Cc1cccc2c1CC2.[BH4-].[Na+].[Na+].[OH-]>>OCc1cccc2c1CC2",
        "output": "356"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Nc1ccc(C(=O)O)cc1[N+](=O)[O-].O.O=N[O-].[I-].[K+].[Na+]>>O=C(O)c1ccc(I)c([N+](=O)[O-])c1",
        "output": "200"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)n1[nH]c(=O)cc1-c1ccc(NC(=O)Cn2c3c(c(-c4cc(Cl)ccc4C#N)cc2=O)C(=O)CC3)cc1.O=C(O)C(F)(F)F>>N#Cc1ccc(Cl)cc1-c1cc(=O)n(CC(=O)Nc2ccc(-c3cc(=O)[nH][nH]3)cc2)c2c1C(=O)CC2",
        "output": "896"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1=COCCC1.C1CCOC1.CCOC(=O)c1n[nH]c(C)c1I.Cc1ccc(S(=O)(=O)O)cc1>>CCOC(=O)c1nn(C2CCCCO2)c(C)c1I",
        "output": "878"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(O)c(Cl)c1.CS(C)=O.N#Cc1ccc(F)cc1Cl.O=C([O-])[O-].[K+].[K+]>>COc1ccc(Oc2ccc(C#N)c(Cl)c2)c(Cl)c1",
        "output": "564"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNCC1.CC(=O)O.Cc1ccccc1.O=C1CSC(=O)N1.O=Cc1ccc(O)cc1>>O=C1NC(=O)C(=Cc2ccc(O)cc2)S1",
        "output": "761"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)P1(=NC(C)(C)C)N(C)CCCN1C.CN(C)C=O.COC(=O)Cc1c(C)[nH]c2ncccc12.O=S(=O)(Cl)c1ccc(F)c(F)c1>>COC(=O)Cc1c(C)n(S(=O)(=O)c2ccc(F)c(F)c2)c2ncccc12",
        "output": "354"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCc1ccccc1.CC(C)Nc1c(N)cc(C(=O)O)cc1S(N)(=O)=O.CCO>>CC(C)Nc1c(NCc2ccccc2)cc(C(=O)O)cc1S(N)(=O)=O",
        "output": "272"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)C(=NOC)c3csc(N)n3)[C@H]2SC1.CC(C)OC(C)C.COc1ccccc1.O=C(O)C(F)(F)F>>C#CC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOC)c3csc(N)n3)[C@H]2SC1",
        "output": "228"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc(CN)[nH]n1.Cc1nc(N2CCN(Cc3ccc(F)cc3)C2=O)sc1C(=O)O.NCc1cccnc1>>Cc1cc(CNC(=O)c2sc(N3CCN(Cc4ccc(F)cc4)C3=O)nc2C)[nH]n1",
        "output": "534"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CNCCO.CN1CCCC1=O.COc1cc2c(Nc3cc(CC(=O)Nc4cc(F)cc(F)c4)[nH]n3)ncnc2cc1OCCCCl.[I-].[K+]>>COc1cc2c(Nc3cc(CC(=O)Nc4cc(F)cc(F)c4)[nH]n3)ncnc2cc1OCCCN(CCO)CC(C)C",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.CCCN1CCC(c2cc(OC)c(N)cc2C)CC1.C[O-].Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O=C(Nc1c(F)cccc1F)c1cccc(-c2nc3ccccn3c2-c2ccnc(Cl)n2)c1.[Na+]>>CCCN1CCC(c2cc(OC)c(Nc3nccc(-c4c(-c5cccc(C(=O)Nc6c(F)cccc6F)c5)nc5ccccn45)n3)cc2C)CC1",
        "output": "808"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COc1ccc(C2=NN(C3CCN(C(=O)[C@@H](N)Cc4c[nH]c5ccccc45)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC.ClCCCl.O.O=C(O)c1c[nH]c2c(-c3c(OCC4CC4)ccc4c3OCO4)ncnc12.On1nnc2ccccc21>>COc1ccc(C2=NN(C3CCN(C(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)c4c[nH]c5c(-c6c(OCC7CC7)ccc7c6OCO7)ncnc45)CC3)C(=O)[C@@H]3CCCC[C@H]23)cc1OC",
        "output": "989"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(C)=O.CCOCC.COC(=O)c1cccc2[nH]ccc12.O=C([O-])C(O)C(O)C(=O)[O-].[H-].[K+].[Na+]>>OCc1cccc2[nH]ccc12",
        "output": "444"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CN(C)C=O.O.O=C(O)C(F)(F)F.O=C([O-])[O-].OB(O)CCCCCBr.[Cs+].[Cs+].c1ccc2[nH]c(-c3cscn3)nc2c1>>OB(O)CCCCCn1c(-c2cscn2)nc2ccccc21",
        "output": "276"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CCOC(C)=O.Cl.N#Cc1ccc2[nH]cc(C3CCC(=O)CC3)c2c1.[Na+].c1cc(N2CCNCC2)c2cccnc2c1>>N#Cc1ccc2[nH]cc(C3CCC(N4CCN(c5cccc6ncccc56)CC4)CC3)c2c1",
        "output": "187"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cnc(CN)cn1.Cc1nc(N2C[C@@H](C)N(Cc3cc(F)cc(F)c3)C2=O)sc1C(=O)O.Cc1nc(N2C[C@H](C)N(Cc3ccc(F)cc3)C2=O)sc1C(=O)O.NCc1cccnc1>>Cc1cnc(CNC(=O)c2sc(N3C[C@@H](C)N(Cc4cc(F)cc(F)c4)C3=O)nc2C)cn1",
        "output": "534"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1ccc(Br)o1.CCO.CN(C)c1ccc(C=O)cc1.[K+].[OH-]>>CN(C)c1ccc(C=CC(=O)c2ccc(Br)o2)cc1",
        "output": "295"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1OCc1nc2cc(Cl)ccc2o1>>NOCc1nc2cc(Cl)ccc2o1",
        "output": "452"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.Cc1ccccc1.Cl.N#Cc1cccc(Cl)c1N.[N-]=[N+]=[N-].[Na+]>>Nc1c(Cl)cccc1-c1nnn[nH]1",
        "output": "390"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.COc1ccnc(C(=O)O)c1OCc1ccccc1.[C].[Pd]>>COc1ccnc(C(=O)O)c1O",
        "output": "264"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1ccc(O)cc1.CC(C)=O.CCOC(=O)CBr.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)COc1ccc(C(C)=O)cc1",
        "output": "123"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.O.O=C1COCCN1c1ccc([N+](=O)[O-])cc1.[H][H].[Pd]>>Nc1ccc(N2CCOCC2=O)cc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.Cc1c(Br)cccc1-n1c(=O)[nH]c2c(C)cccc2c1=O.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1c(Br)cccc1-n1c(=O)c2cccc(C)c2n(C)c1=O",
        "output": "570"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.COC(=O)c1ccc2c(n1)N1[C@H](C)CN(C(=O)OC(C)(C)C)C[C@H]1C2.[H-]>>C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3ccc(CO)nc3N12",
        "output": "546"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)Cc1ccc(NC(=O)Nc2ccccc2)c(Cl)c1.[Na+].[OH-]>>O=C(O)Cc1ccc(NC(=O)Nc2ccccc2)c(Cl)c1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1C[C@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)C[C@H]1CO.ClCCl.O=C(O)C(F)(F)F>>OC[C@@H]1C[C@@H](SC(c2ccccc2)(c2ccccc2)c2ccccc2)CN1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Cl.OC1(c2cncs2)CCC2(CC1)OCCO2.[Na+].[OH-]>>O=C1CCC(O)(c2cncs2)CC1",
        "output": "251"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1c2scnc2[C@H](OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)CC[C@H]1c1cccc(F)c1F.ClCCl.O=C(O)C(F)(F)F>>N[C@@H]1c2scnc2[C@H](OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)CC[C@H]1c1cccc(F)c1F",
        "output": "538"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "FC1(F)CCNC1.O=C(O)c1ccncc1NC(=O)c1nc(C2CC2)ccc1Nc1cncnc1>>O=C(Nc1cnccc1C(=O)N1CCC(F)(F)C1)c1nc(C2CC2)ccc1Nc1cncnc1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.CO.COCOc1cc(C)c(-c2cccc(C(=O)OC)c2C)c(C)c1.Cl>>COC(=O)c1cccc(-c2c(C)cc(O)cc2C)c1C",
        "output": "755"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@]1(c2cc(N)ccc2F)N=C(N)OC[C@@H]1F.N#Cc1cnc(C(=O)O)c(Cl)c1>>C[C@]1(c2cc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)N=C(N)OC[C@@H]1F",
        "output": "985"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "N#Cc1cc(-c2ccnc(Cl)n2)ccc1OC1CCOCC1.Nc1ccc2scnc2c1>>N#Cc1cc(-c2ccnc(Nc3ccc4scnc4c3)n2)ccc1OC1CCOCC1",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)c1cnn(Cc2cc(Cl)ccc2OCc2ccccc2)n1.[Na+].[OH-]>>O=C(O)c1cnn(Cc2cc(Cl)ccc2OCc2ccccc2)n1",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc2cc(OCc3ccccc3)ccc2c1.O.[Li+].[OH-]>>O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccc2cc(OCc3ccccc3)ccc2c1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCC.N#CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1.[Al+3].[Al+3].[Cl-].[Cl-].[Cl-].[H-].[H-].[H-].[H-].[Li+]>>NCCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1",
        "output": "246"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCN(CC)CC.C[C@@H](N)[C@@H](C)O.Cl.FC(F)(F)c1cnc(Cl)nc1Cl.[Cl-].[Na+]>>C[C@@H](O)[C@@H](C)Nc1nc(Cl)ncc1C(F)(F)F",
        "output": "110"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CNCCCOc1ccc(N(C)C)cc1.COc1cc2c(cc1OC)CC(=O)N(CCCCl)CC2>>COc1cc2c(cc1OC)CC(=O)N(CCCN(C)CCCOc1ccc(N(C)C)cc1)CC2",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCO.COc1nc(NCCO)nc(NC2CCN(C(=O)OC(C)(C)C)CC2)n1.Cl.O=C([O-])[O-].[K+].[K+]>>COc1nc(NCCO)nc(NC2CCNCC2)n1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COc1cc2cc(Nc3cc(C)[nH]n3)nc(Cl)c2cc1OC>>COc1cc2cc(Nc3cc(C)[nH]n3)nc(OC)c2cc1OC",
        "output": "433"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "FC(F)(F)c1cc(Cl)nc(-c2cccnc2)n1.Nc1cccc(-c2ccccc2)c1.[Na+].[OH-]>>FC(F)(F)c1cc(Nc2cccc(-c3ccccc3)c2)nc(-c2cccnc2)n1",
        "output": "161"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CN[C@H](C)COc1cccc2ncnc(Nc3ccc(O)c(Cl)c3)c12>>CC(=O)N(C)[C@H](C)COc1cccc2ncnc(Nc3ccc(O)c(Cl)c3)c12",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.CCOC(=O)N1CCN(C(=O)C(N)CCC(=O)OC(C)(C)C)CC1.CCOC(C)=O.CN(C)C=O.CSc1cc(C(=O)O)nc2cc(Cl)ccc12.Cl.On1nnc2ccccc21>>CCOC(=O)N1CCN(C(=O)C(CCC(=O)OC(C)(C)C)NC(=O)c2cc(SC)c3ccc(Cl)cc3n2)CC1",
        "output": "738"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)O.CCCC[N+](CCCC)(CCCC)CCCC.Cc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2[C@H](C)O[Si](C)(C)C(C)(C)C)n1.[F-]>>Cc1nc([C@@H]2C[C@H]2c2nc3ccccc3n2C)cc(-n2nc(C)nc2[C@H](C)O)n1",
        "output": "708"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.C[C@@H]1O[C@@H](OCCNC(=O)CCCCC(=O)NCCCC[C@H](NC(=O)CCCCCCC(=O)OCc2ccccc2)C(=O)O)[C@@H](O)[C@H](O)[C@@H]1O.C[C@@H]1O[C@@H](OCCNC(=O)CCCCCN)[C@@H](O)[C@H](O)[C@@H]1O.ClCCCl.On1nnc2ccccc21>>C[C@@H]1O[C@@H](OCCNC(=O)CCCCCNC(=O)[C@H](CCCCNC(=O)CCCCC(=O)NCCO[C@@H]2O[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]2O)NC(=O)CCCCCCC(=O)OCc2ccccc2)[C@@H](O)[C@H](O)[C@@H]1O",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cn(-c2ccnc3cc(C(F)(F)F)ccc23)c2ccccc12.O.O.[Li+].[OH-]>>O=C(O)c1cn(-c2ccnc3cc(C(F)(F)F)ccc23)c2ccccc12",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.CN(C)c1ccncc1.NCC1CCN(CCOc2ccccc2)CC1.c1ccncc1>>CC(=O)NCC1CCN(CCOc2ccccc2)CC1",
        "output": "339"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NC[C@H](O)COc1ccc(O)cc1.O=C1CCN(c2ccc(C=C3SC(=S)NC3=O)cc2)CC1>>O=C1NC(=S)SC1=Cc1ccc(N2CCC(NC[C@H](O)COc3ccc(O)cc3)CC2)cc1",
        "output": "236"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCOC(C)=O.COC(=O)[C@@H](C)N1CC(c2c(C)c(Cl)cc(C(C)n3nc(C)c4c(N)ncnc43)c2OC)C1.Cl.O.[Li+].[OH-]>>COc1c(C(C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(C)c1C1CN([C@H](C)C(=O)O)C1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.NN.O.O=[N+]([O-])c1c(CS(=O)(=O)c2ccccc2)cccc1OCCCl.[Pd]>>Nc1c(CS(=O)(=O)c2ccccc2)cccc1OCCCl",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC1(C(=O)c2ccc(Cl)cc2)OC1CCCl.COc1ccc(C(=O)C2(OC)OC2CCCl)cc1>>COC1(C(=O)c2ccccc2)OC1CCCl",
        "output": "253"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc(C(=O)N2CCN(C)CC2)ccc1N.Cc1ncc(-c2nc(Cl)ncc2F)n1C>>Cc1cc(C(=O)N2CCN(C)CC2)ccc1Nc1ncc(F)c(-c2cnc(C)n2C)n1",
        "output": "941"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)O.CCO.CC[BH-](CC)CC.COC(=O)c1ccc2cnn(-c3ccnc(N[C@@H]4CC[C@@H](O)CC4)n3)c2c1.Cl.O=C([O-])O.[Li+].[Na+].[Na+].[OH-]>>OCc1ccc2cnn(-c3ccnc(N[C@@H]4CC[C@@H](O)CC4)n3)c2c1",
        "output": "444"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(N)c1nccc2ccccc12.O=C(O)Cn1nc(-c2ccc(Cl)cc2)n(Cc2ccccc2F)c1=O>>CC(NC(=O)Cn1nc(-c2ccc(Cl)cc2)n(Cc2ccccc2F)c1=O)c1nccc2ccccc12",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cc2ccccc2n1CC(=O)Nc1ccc(Cl)cc1.Cl.[K+].[OH-]>>O=C(Cn1c(C(=O)O)cc2ccccc21)Nc1ccc(Cl)cc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(Cc1ccc(OCc2sc(-c3ccccc3Cl)nc2C)cc1C)OCC.[Li+].[OH-]>>CCOC(Cc1ccc(OCc2sc(-c3ccccc3Cl)nc2C)cc1C)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(C(=O)C[C@@H](c2ccc(-c3ccc(C(=O)N[C@H](C)c4ccccc4)cc3)cc2)c2ccccc2C)ccn1.Cl.NO.O=C([O-])O.[Na+]>>Cc1cc(C(C[C@@H](c2ccc(-c3ccc(C(=O)N[C@H](C)c4ccccc4)cc3)cc2)c2ccccc2C)=NO)ccn1",
        "output": "212"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCNc1ncc2cc(-c3ccc(-c4cncc(C)n4)cc3Cl)c(=O)n(CC3CCN(C(=O)OC(C)(C)C)CC3)c2n1.ClCCl.O=C(O)C(F)(F)F>>CCNc1ncc2cc(-c3ccc(-c4cncc(C)n4)cc3Cl)c(=O)n(CC3CCNCC3)c2n1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)c1ccccc1.O=P(Cl)(Cl)Cl.O=[N+]([O-])c1cncc(Br)c1O>>O=[N+]([O-])c1cncc(Br)c1Cl",
        "output": "177"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCc2nc(S(C)(=O)=O)nc(-c3ccc(Cl)cc3Cl)c2C1.ClCCl.O=C(O)C(F)(F)F>>CS(=O)(=O)c1nc2c(c(-c3ccc(Cl)cc3Cl)n1)CNCC2",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.FC(F)(F)Oc1cccc(CBr)c1.O=C([O-])[O-].O=[N+]([O-])c1ccc2[nH]ccc2c1.[K+].[K+]>>O=[N+]([O-])c1ccc2c(ccn2Cc2cccc(OC(F)(F)F)c2)c1",
        "output": "528"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)CCCOc1cccc(C(O)CCNC(=O)OC(C)(C)C)c1.CO.[Na+].[OH-]>>CC(C)(C)OC(=O)NCCC(O)c1cccc(OCCCC(=O)O)c1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.CCOC(=O)c1cc(C)c2[nH]c(=O)n(-c3cc(S(=O)(=O)N4CCCCc5ccccc54)ccc3Cl)c2n1.Cl.[H-]>>Cc1cc(CO)nc2c1[nH]c(=O)n2-c1cc(S(=O)(=O)N2CCCCc3ccccc32)ccc1Cl",
        "output": "711"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.CO.F[P-](F)(F)(F)(F)F.NC1CCC1.Nc1ccc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c(CC(=O)O)c1.O.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>Nc1ccc(S(=O)(=O)Nc2ccc3c(c2)B(O)OC3)c(CC(=O)NC2CCC2)c1",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.C1=CCCCC1.COc1ccc(S(=O)(=O)N2c3ccccc3-c3ccc(F)cc3[C@@H]2C)cc1.O=C([O-])O.[Na+]>>C[C@H]1c2cc(F)ccc2-c2ccccc2N1S(=O)(=O)c1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cc(CC(=O)OC(C)(C)C)cnc1OCC[C@@H]1C[C@@H]1C1CCNCC1.ClCCl.N#CBr.O=C([O-])[O-].[K+].[K+]>>Cc1cc(CC(=O)OC(C)(C)C)cnc1OCC[C@@H]1C[C@@H]1C1CCN(C#N)CC1",
        "output": "532"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)[Si](C)(C)OCC(N)c1cc(Br)cs1.CC(C)CC=O.CO.[BH4-].[Na+]>>CC(C)CCNC(CO[Si](C)(C)C(C)(C)C)c1cc(Br)cs1",
        "output": "426"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)OC(C)C.CCCCCC.CSC(=C(C#N)C#N)N1CCC(CN2CCCC2C)CC1.NC1CCN(Cc2ccccc2)CC1>>CC1CCCN1CC1CCN(C(NC2CCN(Cc3ccccc3)CC2)=C(C#N)C#N)CC1",
        "output": "270"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCC(C)(C)c1ccc(C2=CC(=O)CCC2)c(O)c1.CCOCC.CO.[BH4-].[Cl-].[Na+].[Na+]>>CCCCCCC(C)(C)c1ccc(C2=CC(O)CCC2)c(O)c1",
        "output": "288"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C(=O)O)(c1ccccc1)c1ccccc1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C(=O)Cl)(c1ccccc1)c1ccccc1",
        "output": "56"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc2sc(C(=O)OC(C)(C)C)cc2c1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)c1cc2cc(CBr)ccc2s1",
        "output": "29"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Nc1c(OCCCCBr)ccc2[nH]c(=O)ccc12.CC(=O)O.CC(=O)OC(C)=O.O=c1ccc2c([N+](=O)[O-])c(OCCCCBr)ccc2[nH]1.Sc1ccccc1.[Zn]>>CC(=O)Nc1c(OCCCCSc2ccccc2)ccc2[nH]c(=O)ccc12",
        "output": "124"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(N)CO.CCC(Oc1ccc2ccc(Br)cc2c1)C(=O)O.CCN(C(C)C)C(C)C.C[n+]1ccccc1Cl.ClCCl.[I-]>>CCC(Oc1ccc2ccc(Br)cc2c1)C(=O)NC(C)(C)CO",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN.CN(C)C=O.Cl.O.O=C(O)c1cc(Br)ccn1.On1nnc2ccccc21>>CNC(=O)c1cc(Br)ccn1",
        "output": "137"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COc1ccc(-c2ccc(C=O)c(Cl)c2)cc1F>>O=Cc1ccc(-c2ccc(O)c(F)c2)cc1Cl",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.N#Cc1ccc(CN)cc1.O.O=[N+]([O-])c1cc(OCc2ccc3ccccc3n2)ccc1F>>N#Cc1ccc(CNc2ccc(OCc3ccc4ccccc4n3)cc2[N+](=O)[O-])cc1",
        "output": "764"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCOCC1.COC(=O)c1ccc(Cc2cn(C)c3ccc(N)cc23)c(OC)c1.Cc1ccccc1.O=C(Cl)OC1CCCC1>>COC(=O)c1ccc(Cc2cn(C)c3ccc(NC(=O)OC4CCCC4)cc23)c(OC)c1",
        "output": "102"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.CN(C)S(=O)(=O)c1cc(Cl)ccc1[N+](=O)[O-].CNC.Cl.O.O=C([O-])[O-].[K+].[K+]>>CN(C)c1ccc([N+](=O)[O-])c(S(=O)(=O)N(C)C)c1",
        "output": "105"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CS(C)=O.Clc1ccccc1.O.O=C(O)C(F)(F)F.OCCCc1c[nH]c2ccc(F)cc12.c1ccncc1>>O=CCCc1c[nH]c2ccc(F)cc12",
        "output": "142"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(C(C)O)cc1.Cl.[K+].[OH-]>>CC(O)c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOCCCC(=O)OCC.[Na+].[OH-]>>CCOCCCC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.N.O.O=S(=O)(Cl)c1ccccc1OC(F)F>>NS(=O)(=O)c1ccccc1OC(F)F",
        "output": "245"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[SiH2]OC(C)(C)C1CC(O)(C#C[Si](C)(C)C)CCO1.O=C([O-])[O-].[K+].[K+]>>C#CC1(O)CCOC(C(C)(C)O[SiH2]C(C)(C)C)C1",
        "output": "337"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.CC1(C)C(=O)N(CCCN2CCOCC2)c2cc(N)ccc21.[Na+].[OH-]>>CC(=O)Nc1ccc2c(c1)N(CCCN1CCOCC1)C(=O)C2(C)C",
        "output": "6"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)I.O.O=C([O-])[O-].Oc1ccc(Br)cc1.[K+].[K+]>>CC(C)Oc1ccc(Br)cc1",
        "output": "318"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(O[C@H](C)C(=O)OCc3ccccc3)n(-c3ccccc3)n2)CC1.CCOC(C)=O>>CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(O[C@H](C)C(=O)O)n(-c3ccccc3)n2)CC1",
        "output": "186"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNC1.CCN(CC)CC.ClCCl.O=S(=O)(Cl)c1ccc(F)cc1>>O=S(=O)(c1ccc(F)cc1)N1CCCC1",
        "output": "99"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccccc1C=O.Nc1cccc(-c2c(Cc3ccccc3)cnc3c(C(F)(F)F)cccc23)c1>>COc1ccccc1CNc1cccc(-c2c(Cc3ccccc3)cnc3c(C(F)(F)F)cccc23)c1",
        "output": "359"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.CCN=C=NCCCN(C)C.Cl.N[C@@H]1CCC[C@H](O)C1.O.O=C(O)c1noc(-c2ccc(C(F)(F)F)cc2)c1F.On1nnc2ccccc21>>O=C(N[C@@H]1CCC[C@H](O)C1)c1noc(-c2ccc(C(F)(F)F)cc2)c1F",
        "output": "696"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1ccccc1Br.CN(C)C=O.COC(=O)c1ccc[nH]c1=O.Cl.[H-].[Na+]>>COC(=O)c1cccn(Cc2ccccc2Br)c1=O",
        "output": "528"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CO.ClC(Cl)Cl.ClC(Cl)Cl.NCC(CN)c1ccccc1.O=S(=O)(Cl)c1cccc2cnccc12>>NCC(CNS(=O)(=O)c1cccc2cnccc12)c1ccccc1",
        "output": "43"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(-c2ccccc2O)cc1.CC(C)I>>CC(C)Oc1ccccc1-c1ccc(CNC(=O)OC(C)(C)C)cc1",
        "output": "318"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCNC(=O)Nc1ccc(Oc2ccnc3cc(O)c(OC)cc23)cc1Cl.CN(C)C=O.Cl.ClCc1ccccn1.O.O=C([O-])[O-].[K+].[K+]>>CCCNC(=O)Nc1ccc(Oc2ccnc3cc(OCc4ccccn4)c(OC)cc23)cc1Cl",
        "output": "616"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.CC1(C)CCC(=O)CC1.CO>>CC1(C)CCC(=O)C(Br)C1",
        "output": "82"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1ncoc1C(C)C.O.[K+].[OH-]>>CC(C)c1ocnc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CNC(=O)c1nc(CC2CCN(c3ccc(Cc4ccccc4)cc3)CC2)nc(C)c1O.CN(C)C=O.O=C([O-])O.O=C1CCC(=O)N1Br.[Na+]>>CCOC(=O)CNC(=O)c1nc(CC2CCN(c3ccc(Cc4ccccc4)cc3Br)CC2)nc(C)c1O",
        "output": "4"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)c(C)c3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCCOc1cccc(F)c1>>COc1cc2nccc(Oc3ccc(NC(=O)OCCOc4cccc(F)c4)c(C)c3C)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN1CCN(c2nc(C)nc3c2nc(-c2ccccc2Cl)n3C2CN(C(=O)OC(C)(C)C)C2)CC1.ClCCl.O=C(O)C(F)(F)F>>CCN1CCN(c2nc(C)nc3c2nc(-c2ccccc2Cl)n3C2CNC2)CC1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(ON2C(=O)c3ccccc3C2=O)CC1.ClCCl.NN.O>>CC(C)(C)OC(=O)N1CCC(ON)CC1",
        "output": "452"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.N.N#CCCCCn1c(CN2CCC[C@@H]3CCc4cccnc4[C@H]32)nc2ccccc21.[Ni]>>NCCCCCn1c(CN2CCC[C@@H]3CCc4cccnc4[C@H]32)nc2ccccc21",
        "output": "246"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCCC1=O.COc1ccc(Cn2nnc3c(O)c(Cl)ccc32)cc1.N#Cc1cc(F)cc(Cl)c1.O=C([O-])[O-].[Cs+].[Cs+]>>COc1ccc(Cn2nnc3c(Oc4cc(Cl)cc(C#N)c4)c(Cl)ccc32)cc1",
        "output": "845"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CNCCN1.CCOC(C)=O.Cc1cc(-c2nc(-c3ccc(C4(C(F)(F)F)CC4)cc3)no2)nn1Cc1ccnc(Cl)c1.O>>Cc1cc(-c2nc(-c3ccc(C4(C(F)(F)F)CC4)cc3)no2)nn1Cc1ccnc(N2CCNCC2)c1",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NCc1csc(-c2ccccc2)n1.O=C(O)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1>>O=C(NCc1csc(-c2ccccc2)n1)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COc1ccc(-c2sc3cc(OC)ccc3c2Nc2ccc(OCCN3CCCCC3)cc2)cc1.Cl.ClCCl>>Oc1ccc(-c2sc3cc(O)ccc3c2Nc2ccc(OCCN3CCCCC3)cc2)cc1",
        "output": "20"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNCC1.CN(C)C=O.COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(CCl)cc4)CC3)c2cc1OC.O>>COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(CN5CCCCC5)cc4)CC3)c2cc1OC",
        "output": "156"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.Cc1cc2ccccc2cn1.ClCCl.O=S(=O)(O)O.O=[N+]([O-])O.[Na+].[OH-]>>Cc1cc2c([N+](=O)[O-])cccc2cn1",
        "output": "21"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCO.CN.CN(C)C(On1nnc2ccccc21)=[N+](C)C.C[C@H](NC(=O)c1ccc(C(=O)N2CCCC2CCC(=O)O)c(Cl)c1)c1nc2cc(Cl)ccc2[nH]1.ClCCl.ClCl.F[B-](F)(F)F>>CNC(=O)CCC1CCCN1C(=O)c1ccc(C(=O)N[C@@H](C)c2nc3cc(Cl)ccc3[nH]2)cc1Cl",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCOC(=O)c1coc2cc(NS(C)(=O)=O)c(Oc3ccccc3)cc2c1=O.Cl.O>>CS(=O)(=O)Nc1cc2occ(C(=O)O)c(=O)c2cc1Oc1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccccc1N1CCNCC1.COc1nc(C)c(C)nc1NC(=O)Oc1ccccc1>>COc1ccccc1N1CCN(C(=O)Nc2nc(C)c(C)nc2OC)CC1",
        "output": "525"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCN=[N+]=[N-])c2)cc1.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCN)c2)cc1",
        "output": "89"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.[N-]=[N+]=NC[C@H]1CN(c2ccc3c(c2)CC(=O)CCC3)C(=O)O1.[Pd]>>NC[C@H]1CN(c2ccc3c(c2)CC(=O)CCC3)C(=O)O1",
        "output": "89"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCOc1cnc(-c2ccc(O)cc2)nc1.F[C@@H](COCCCCl)COCC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>CCCCCCOc1cnc(-c2ccc(OCCCOC[C@H](F)COCC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc2)nc1",
        "output": "74"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.Cc1ccc(S(=O)(=O)OCCC(C)(C)O)cc1.ClCCl.O>>CC(=O)OC(C)(C)CCOS(=O)(=O)c1ccc(C)cc1",
        "output": "126"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.Cc1cc(N)c([N+](=O)[O-])cc1N.O.O=C(Cl)OCCCl.O=C([O-])[O-].[K+].[K+]>>Cc1cc(N)c([N+](=O)[O-])cc1NC(=O)OCCCl",
        "output": "102"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCn1cc(C(=O)O)c(=O)c2cc(F)c(F)c(F)c21.FCC1CNCCN1.c1ccncc1>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(CF)C3)c(F)c21",
        "output": "676"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CCO.Cc1[nH]c(C=O)c(C)c1C(=O)NCCN(C(C)C)C(C)C.O=C1Cc2c(cccc2-c2cccc(Br)c2)N1>>Cc1[nH]c(C=C2C(=O)Nc3cccc(-c4cccc(Br)c4)c32)c(C)c1C(=O)NCCN(C(C)C)C(C)C",
        "output": "440"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COCOc1ccc2cc(CCC(=O)CCc3cccnc3)ccc2c1.[BH4-].[Na+]>>COCOc1ccc2cc(CCC(O)CCc3cccnc3)ccc2c1",
        "output": "91"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COC(=O)Cl.Cl.ClCCl.Fc1cnc(-c2c[nH]c3ncc(Cl)cc23)nc1N[C@H]1CCCNC1.Fc1cnc(-c2c[nH]c3ncc(Cl)cc23)nc1N[C@H]1CCCNC1>>COC(=O)N1CCC[C@H](Nc2nc(-c3c[nH]c4ncc(Cl)cc34)ncc2F)C1",
        "output": "219"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.NC1CCC1.O=S(=O)(Cl)c1ccc(Br)c(F)c1>>O=S(=O)(NC1CCC1)c1ccc(Br)c(F)c1",
        "output": "43"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(OC(c2sc(-c3ccc(C(F)(F)F)cc3)cc2C)C2CCCCC2)cc1.Cl.O.[Na+].[OH-]>>Cc1cc(-c2ccc(C(F)(F)F)cc2)sc1C(Oc1ccc(C(=O)O)cc1)C1CCCCC1",
        "output": "222"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)Cl.C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)NC3CC3)cc2)nc2c1CCNC2>>COC(=O)N1CCc2c(nc(-c3ccc(NC(=O)NC4CC4)cc3)nc2N2CCOC[C@@H]2C)C1",
        "output": "219"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCNC(=O)[C@H]1O[C@@H]1C(=O)OCC.CCO.[K+].[OH-]>>CCCNC(=O)[C@H]1O[C@@H]1C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(C2(O)CCC(=O)CC2)c1.O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1>>CC(C)(C)OC(=O)Nc1cccc(C2(O)CCC(N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1",
        "output": "187"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CO.Cc1ncnc2c1c(NCc1ccc(NS(C)(=O)=O)cc1)cc(=O)n2OCc1ccccc1.[C].[H][H].[OH-].[OH-].[Pd+2]>>Cc1ncnc2c1c(NCc1ccc(NS(C)(=O)=O)cc1)cc(=O)n2O",
        "output": "630"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCNCC1.Cc1ccc(S(=O)(=O)OCCOCCOCCOCCN2C(=O)c3ccccc3C2=O)cc1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(CCOCCOCCOCCN2C(=O)c3ccccc3C2=O)CC1",
        "output": "429"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.Cc1cc(Br)c(Cl)cc1CC(=O)O.Cc1ccccc1.N#CC1(O)CCCCC1.O=C(Cl)C(=O)Cl>>Cc1cc(Br)c(Cl)cc1CC(=O)OC1(C#N)CCCCC1",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(N)CO.CCO.CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN(C)C(C)=O)c1=O>>CC(=O)N(C)CCn1c(=O)c(C(=O)NC(C)CO)c(O)c2ncc(Cc3ccc(F)cc3)cc21",
        "output": "498"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)Cl)cc1.CN1Cc2cc(-c3ccc(-c4cncc(N)c4)s3)ccc2C1=O>>CN1Cc2cc(-c3ccc(-c4cncc(NS(=O)(=O)c5ccc(C(C)(C)C)cc5)c4)s3)ccc2C1=O",
        "output": "554"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ncc(C(=O)O)cn1.N#Cc1cc(F)ccc1Nc1ccc(CNC(=O)C2(N)CC2)cc1.O=C(O)C(F)(F)F>>Cc1ncc(C(=O)NC2(C(=O)NCc3ccc(Nc4ccc(F)cc4C#N)cc3)CC2)cn1",
        "output": "989"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC1(C)CC(N)CC(C)(C)N1.O=C(O)c1ccc(-c2cc3cc(Cl)c(Cl)cc3[nH]2)c(OCc2ccccc2)c1.On1nnc2ccccc21>>CC1(C)CC(NC(=O)c2ccc(-c3cc4cc(Cl)c(Cl)cc4[nH]3)c(OCc3ccccc3)c2)CC(C)(C)N1",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)c1ccc(N)cc1NC(=O)CN1CCOCC1.CCN(C(C)C)C(C)C.CN(C)C=O.O=C(O)c1ccc(-c2ccccc2)cc1>>CC(C)(C)c1ccc(NC(=O)c2ccc(-c3ccccc3)cc2)cc1NC(=O)CN1CCOCC1",
        "output": "50"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CNC3)n(C)c2n1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@@H](O)C(=O)O.ClCCl.F[P-](F)(F)(F)(F)F>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CN(C(=O)[C@@H](C)O)C3)n(C)c2n1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(C)CC(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N#CCCN1CCC(Nc2c(N)cnc3c2ccn3S(=O)(=O)c2ccccc2)CC1>>CCC(C)CC(=O)Nc1cnc2c(ccn2S(=O)(=O)c2ccccc2)c1NC1CCN(CCC#N)CC1",
        "output": "724"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.CC(=O)O.CCc1ccc(OC)c(OC)c1.O>>CCc1ccc(O)c(O)c1",
        "output": "19"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cc(F)ccc1Oc1ccc(C(F)(F)F)cc1C(=O)Nc1ccc(C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(F)ccc1Oc1ccc(C(F)(F)F)cc1C(=O)Nc1ccc(C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCS(=O)(=O)Cl.Cc1cc(CNC(=O)CCC2CCNCC2)ccc1C(=O)N1Cc2cnn(C)c2Nc2cc(Cl)ccc21.Cl.ClCCl>>CCS(=O)(=O)N1CCC(CCC(=O)NCc2ccc(C(=O)N3Cc4cnn(C)c4Nc4cc(Cl)ccc43)c(C)c2)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2ccc(OCCCOCc3ccsc3)cc2)C(O)C1.COCCCOc1cc(CCl)cc2c(OC)cccc12>>COCCCOc1cc(COC2CN(C(=O)OC(C)(C)C)CCC2c2ccc(OCCCOCc3ccsc3)cc2)cc2c(OC)cccc12",
        "output": "208"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.N#Cc1cc(F)c(Nc2cc(C3CC3)[nH]n2)nc1N[C@@H](CO)c1ccc(F)cc1.OO.[K+].[OH-]>>NC(=O)c1cc(F)c(Nc2cc(C3CC3)[nH]n2)nc1N[C@@H](CO)c1ccc(F)cc1",
        "output": "677"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN1CCOCC1.CCN=C=NCCCN(C)C.CN(C)C=O.COc1ccc(N)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1Cl.C[C@H](C(=O)O)N(C)C(=O)OC(C)(C)C.Cl.O.O=C([O-])O.On1nnc2ccccc21.[Na+]>>COc1ccc(NC(=O)[C@@H](C)N(C)C(=O)OC(C)(C)C)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1Cl",
        "output": "646"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cc1ccc([N+](=O)[O-])c(OC(C)C)c1.[H][H].[Pd]>>Cc1ccc(N)c(OC(C)C)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN.CO.COC(OC)c1nc2c(cc1C=O)CCCN2.[BH4-].[Na+]>>CNCc1cc2c(nc1C(OC)OC)NCCC2",
        "output": "441"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COCCOC.COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(Br)c1)CC2.O.O=C([O-])[O-].OB(O)c1ccccc1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccccc3)c1)CC2",
        "output": "833"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)Cn1ccn2nccc12.[NH4+].[OH-]>>NC(=O)Cn1ccn2nccc12",
        "output": "163"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(n2nnc3c(N4CCOCC4)nc(-c4cccc(O)c4)nc32)CC1.ClC(Cl)Cl.O=C(O)C(F)(F)F>>Oc1cccc(-c2nc(N3CCOCC3)c3nnn(C4CCNCC4)c3n2)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccccc1-c1cc(C#N)cc2c1OC(CN=[N+]=[N-])C2.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1ccccc1-c1cc(C#N)cc2c1OC(CN)C2",
        "output": "89"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COc1cc(CN)on1.Cl.F[B-](F)(F)F.O=C(O)c1cc(-c2ccc(Cl)cc2)c(OCC(F)(F)F)cn1>>COc1cc(CNC(=O)c2cc(-c3ccc(Cl)cc3)c(OCC(F)(F)F)cn2)on1",
        "output": "137"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C)C=O.Cc1cc(Br)cc2c1OCC2(C)C.[Li]CCCC>>Cc1cc(C=O)cc2c1OCC2(C)C",
        "output": "638"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccccc1.CN(C)C=O.COC(=O)c1ccc(O)c(C(=O)O)c1.O>>COC(=O)c1ccc(O)c(C(=O)OCc2ccccc2)c1",
        "output": "403"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CO.O=C([O-])[O-].O=C(c1cc2nccc(Cl)c2s1)N1CCCC1.O=[N+]([O-])c1ccc(O)c(F)c1.[K+].[K+].c1ccc(Oc2ccccc2)cc1>>O=C(c1cc2nccc(Oc3ccc([N+](=O)[O-])cc3F)c2s1)N1CCCC1",
        "output": "936"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CO.ClCCl.FC(F)(F)c1cc(OCCCN2CCCCC2)ccc1N1CCNCC1.N#Cc1ccc(C(=O)O)cc1.O.On1nnc2ccccc21>>N#Cc1ccc(C(=O)N2CCN(c3ccc(OCCCN4CCCCC4)cc3C(F)(F)F)CC2)cc1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)O.CNC(=O)c1ccccc1Nc1nc(Cl)ncc1Cl.COCCN1CCc2cc(N)c(OC)cc2CC1.Cl>>CNC(=O)c1ccccc1Nc1nc(Nc2cc3c(cc2OC)CCN(CCOC)CC3)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(O[C@@H]2CCCC[C@H]2N2CCCCC2)cc1.[Na+].[OH-]>>O=C(O)c1ccc(O[C@@H]2CCCC[C@H]2N2CCCCC2)cc1",
        "output": "222"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1cnn(C2CCNCC2)c1.CC#N.CCN(C(C)C)C(C)C.CS(=O)(=O)Cl.Cl>>CS(=O)(=O)N1CCC(n2cc(Br)cn2)CC1",
        "output": "584"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cl.FC(F)(F)c1ccc(Cl)nc1.O.O=C([O-])[O-].O[C@@H]1CCNC1.O[C@@H]1CCNC1.[K+].[K+]>>O[C@@H]1CCN(c2ccc(C(F)(F)F)cn2)C1",
        "output": "220"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCc1c(OCCCOc2cc(OCc3ccccc3)c(-c3ccc(F)cc3)cc2CC)cccc1C(=O)O.CN(C)C=O.CO.O.O=S(Cl)Cl.[NH4+].[OH-]>>CCCc1c(OCCCOc2cc(OCc3ccccc3)c(-c3ccc(F)cc3)cc2CC)cccc1C(N)=O",
        "output": "358"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C[C@@H](c1ccc(OC(=O)OC(C)(C)C)cc1F)[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.FC1(F)CCNC1>>C[C@@H](c1ccc(OC(=O)OC(C)(C)C)cc1F)[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC(F)(F)C1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.F[P-](F)(F)(F)(F)F.NCC(=O)NCC(F)(F)F.O.O=C(O)c1ccc(/C=C/C(c2cc(Cl)c(F)c(Cl)c2)C(F)(F)F)cc1OC(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>O=C(CNC(=O)c1ccc(/C=C/C(c2cc(Cl)c(F)c(Cl)c2)C(F)(F)F)cc1OC(F)(F)F)NCC(F)(F)F",
        "output": "718"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COC(=O)c1ccc(CN)cc1.O=C([O-])O.O=Cc1ccc(O)cc1.[BH4-].[Na+].[Na+]>>COC(=O)c1ccc(CNCc2ccc(O)cc2)cc1",
        "output": "683"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1CCC[C@@H]1Cc1c[nH]c2ccc(C=CCCO)cc12.ClCCl.[Pd]>>CN1CCC[C@@H]1Cc1c[nH]c2ccc(CCCCO)cc12",
        "output": "362"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.O=C(Cl)CCl.O[C@H](CNCc1ccccc1)c1ccc(F)cc1.[Na+].[OH-]>>O=C(CCl)N(Cc1ccccc1)C[C@@H](O)c1ccc(F)cc1",
        "output": "240"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(C(C)C)C(C)C.Cc1c(CCN2CCNCC2)ccc2c1COC2=O.ClCCl.N#Cc1ccc2c(c1)OCCC2C=O.[Na+]>>Cc1c(CCN2CCN(CC3CCOc4cc(C#N)ccc43)CC2)ccc2c1COC2=O",
        "output": "484"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cc1oc(-c2ccccc2)nc1COc1cc(COc2ncccc2CC#N)on1.Cl.O.[Na+].[OH-]>>Cc1oc(-c2ccccc2)nc1COc1cc(COc2ncccc2CC(=O)O)on1",
        "output": "259"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NCCO.O=C(O)C1=Cc2c(ncnc2Nc2ccc(Oc3cccc(C(F)(F)F)c3)c(Cl)c2)NCC1.On1nnc2ccccc21>>O=C(NCCO)C1=Cc2c(ncnc2Nc2ccc(Oc3cccc(C(F)(F)F)c3)c(Cl)c2)NCC1",
        "output": "549"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CS(=O)(=O)OCCCCC1C(=O)Nc2ccccc21.Clc1cccc(N2CCNCC2)c1>>O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1",
        "output": "496"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Cl.O=C(O)c1ccc(Br)c(F)c1.O=C1CCCC1.[Cl-].[Li]CCCC.[NH4+]>>O=C(O)c1ccc(C2(O)CCCC2)c(F)c1",
        "output": "321"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)[C@H](C(=O)O)[C@@H]1C#CC(=O)OCC(Cl)(Cl)Cl.C[C@@H](O)c1cccc(Oc2ccccc2)c1>>C[C@@H](OC(=O)[C@@H]1[C@H](C#CC(=O)OCC(Cl)(Cl)Cl)C1(C)C)c1cccc(Oc2ccccc2)c1",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br[Mg]c1ccccc1.C1CCOC1.O=Cc1cccc(/C=C/c2ccc3ccccc3n2)c1.[Cl-].[NH4+]>>OC(c1ccccc1)c1cccc(/C=C/c2ccc3ccccc3n2)c1",
        "output": "309"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)C(Cc1ccc(-c2cccc([N+](=O)[O-])c2)nc1)NC(=O)C1(NC(=O)C(SC(C)=O)C(C)C)CCCC1.[Pd]>>CCOC(=O)C(Cc1ccc(-c2cccc(N)c2)nc1)NC(=O)C1(NC(=O)C(SC(C)=O)C(C)C)CCCC1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(Nc2ncc3c(n2)-c2ccc(C#CCNC(=O)OC(C)(C)C)cc2NC(=O)C3)cc1OC.COc1ccc(Nc2ncc3c(n2)-c2ccc(CCCNC(=O)OC(C)(C)C)cc2NC(=O)C3)cc1OC>>COc1ccc(Nc2ncc3c(n2)-c2ccc(CCCN)cc2NC(=O)C3)cc1OC",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.O.OCC1CCCNC1>>CC(C)(C)OC(=O)N1CCCC(CO)C1",
        "output": "694"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CS(=O)(=O)c1ccc(N2CCC3(CC2)OCCO3)cc1.O.O=S(=O)(O)O>>CS(=O)(=O)c1ccc(N2CCC(=O)CC2)cc1",
        "output": "251"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Nc1cc(Cl)cc(Br)c1F.ClCCl.O=C(O)C(F)(F)F>>Nc1cc(Cl)cc(Br)c1F",
        "output": "782"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)/C=C/c1ccc(Cl)cc1Cn1nnc(C)n1.[Na+].[OH-]>>Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)O)n1",
        "output": "122"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CCN(CCO)c1c([N+](=O)[O-])cc(C(F)(F)F)cc1[N+](=O)[O-].CN(C)C=O.O=S(Cl)Cl.c1ccccc1>>C=CCN(CCCl)c1c([N+](=O)[O-])cc(C(F)(F)F)cc1[N+](=O)[O-]",
        "output": "96"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)Oc1cc(Cl)ccc1CO.CCOCC.O.O=S(Cl)Cl.c1ccncc1>>CC(C)Oc1cc(Cl)ccc1CCl",
        "output": "81"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.CCN(C(C)C)C(C)C.COc1cc(OC[C@H]2CCCN2)c2c(Nc3ccc(F)c(Cl)c3)ncnc2c1.ClCCl>>COc1cc(OC[C@H]2CCCN2C(C)=O)c2c(Nc3ccc(F)c(Cl)c3)ncnc2c1",
        "output": "125"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)CCCOc1nc(Cl)c(Cl)cc1C#N.OB1OCc2cc(O)c(F)cc21>>CC(=O)CCCOc1nc(Oc2cc3c(cc2F)B(O)OC3)c(Cl)cc1C#N",
        "output": "516"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCC.COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(C(CNC(=O)OC(C)(C)C)C(C)C)cc1.Cl>>COc1ccc2[nH]c(=O)c3sccc3c2c1-c1ccc(C(CN)C(C)C)cc1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1c2n(c3c(Br)cc(C#N)cc13)CCNC2=O.OB(O)c1ccc(Cl)cc1>>Cc1c2n(c3c(-c4ccc(Cl)cc4)cc(C#N)cc13)CCNC2=O",
        "output": "833"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Br.CC(=O)O.COc1ccc2c(c1)CCCC2=O.O>>O=C1CCCc2cc(O)ccc21",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CCN(CC)CC.ClCCl.O=C(Nc1ncc(F)s1)[C@H](C[C@H]1CCNC1)c1ccc(S(=O)(=O)C2CC2)cc1>>CC(=O)N1CC[C@H](C[C@@H](C(=O)Nc2ncc(F)s2)c2ccc(S(=O)(=O)C3CC3)cc2)C1",
        "output": "125"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)O)n(-c3ccccc3)n2)CC1.CCOC(C)=O.CN(C)C=O.ClCCCl.O=C(OCc1ccccc1)C1CCNC1.On1nnc2ccccc21>>CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2cc(OCC(=O)N3CCC(C(=O)OCc4ccccc4)C3)n(-c3ccccc3)n2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.C[C@H](N)c1nc2ccc(F)c(Br)c2n1-c1ccccc1.Clc1ncnc2c1ncn2C1CCCCO1>>C[C@H](Nc1ncnc2c1ncn2C1CCCCO1)c1nc2ccc(F)c(Br)c2n1-c1ccccc1",
        "output": "145"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc2nc(-c3ccccc3)n(C3CCN(C(=O)OC(C)(C)C)CC3)c2n1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>Cc1ccc2nc(-c3ccccc3)n(C3CCNCC3)c2n1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.Nc1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1>>CC(=O)Nc1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1",
        "output": "724"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCC(=O)CC1.Cc1cc2cc(NS(C)(=O)=O)ccc2[nH]1>>Cc1[nH]c2ccc(NS(C)(=O)=O)cc2c1C1=CCN(C)CC1",
        "output": "607"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.COc1ccc(NC(=O)c2csc3cnc(Cl)nc23)nc1OC.ClCCl.N[C@@H]1CCCC[C@@H]1N.O>>COc1ccc(NC(=O)c2csc3cnc(N[C@@H]4CCCC[C@@H]4N)nc23)nc1OC",
        "output": "544"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCC2(CCNC2)CC1.CCOC(C)=O.Cl.O=C(Nc1cccnc1)Oc1ccccc1>>CC(C)(C)OC(=O)N1CCC2(CCN(C(=O)Nc3cccnc3)C2)CC1",
        "output": "525"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)CN1CCC(c2n[nH]c3cc(/C=C/C4CCN(C(=O)OC(C)(C)C)CC4)ccc23)CC1.CN(C)C=O.ClCc1ccc(Cl)cc1.[H-].[Na+]>>CC(C)(C)OC(=O)CN1CCC(c2nn(Cc3ccc(Cl)cc3)c3cc(/C=C/C4CCN(C(=O)OC(C)(C)C)CC4)ccc23)CC1",
        "output": "842"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCCBr.N#Cc1ccc(-c2ccc(O)cc2)cc1F>>N#Cc1ccc(-c2ccc(OCCCCl)cc2)cc1F",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCO.CCOC(=O)CC(=O)c1ccc2c(cnn2C)c1.Cc1ccc(S(=O)(=O)O)cc1.N#Cc1cn[nH]c1N>>Cn1ncc2cc(-c3cc(=O)n4ncc(C#N)c4[nH]3)ccc21",
        "output": "513"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cccc2c(=O)nc(-c3cccc(C(=O)OC(C)(C)C)n3)sc12.O=C(O)C(F)(F)F>>Cc1cccc2c(=O)nc(-c3cccc(C(=O)O)n3)sc12",
        "output": "569"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.COC(=O)c1cc(OC)ccc1[N+](=O)[O-].[Na+].[OH-]>>COc1ccc([N+](=O)[O-])c(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.ClCCl.F[P-](F)(F)(F)(F)F.NC1CCC1.O=C(O)COc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3ccccc3n2)c1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>O=C(COc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3ccccc3n2)c1)NC1CCC1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)CCCOc1ccc(-c2cnc(Nc3ccccc3)s2)cc1.Cl.ClCCN1CCOCC1.Oc1ccc(Nc2ncc(-c3ccsc3)s2)cc1>>c1cc(-c2cnc(Nc3ccc(OCCN4CCOCC4)cc3)s2)cs1",
        "output": "74"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1cnc2ncccc2c1.CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(B2OC(C)(C)C(C)(C)O2)c(F)c1>>CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3ncccc3c2)c(F)c1",
        "output": "938"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CCOC(C)=O.Cc1cccc2nc(S)n(C)c(=O)c12.O=C(c1ccc(F)cc1)c1ccc(CBr)cc1.[Na+].[OH-]>>Cc1cccc2nc(SCc3ccc(C(=O)c4ccc(F)cc4)cc3)n(C)c(=O)c12",
        "output": "699"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1cccc(-c2ccccc2-c2ccccc2OCc2ccccc2)c1.O.[Na+].[OH-]>>O=C(O)c1cccc(-c2ccccc2-c2ccccc2OCc2ccccc2)c1",
        "output": "5"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.CO.COC(=O)c1cc([N+](=O)[O-])ccc1C.Cc1ccc([N+](=O)[O-])cc1C(=O)O.Cl.ClC(Cl)Cl.O=C1CCC(=O)N1Br>>COC(=O)c1cc([N+](=O)[O-])ccc1CBr",
        "output": "545"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.ClCCl.O=C(N[C@@H]1CC[C@@H](CNc2ncc3ncnc(Nc4ccc(F)c(Cl)c4)c3n2)CC1)OCc1ccccc1>>N[C@@H]1CC[C@@H](CNc2ncc3ncnc(Nc4ccc(F)c(Cl)c4)c3n2)CC1",
        "output": "574"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(C(C)C(C)C)cc1.O.O.[Li+].[OH-]>>CC(C)C(C)c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrBr.CNC(=O)c1ccc(C)c(Nc2cc(N(C)CC(C)(C)C)ncn2)c1.ClCCl.O.O=C([O-])O.[Na+]>>CNC(=O)c1ccc(C)c(Nc2ncnc(N(C)CC(C)(C)C)c2Br)c1",
        "output": "381"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.COc1cc(Cl)ccc1Br.O.O=C([O-])[O-].[Na+].[Na+]>>CCOC(=O)C1(c2ccc(-c3ccc(Cl)cc3OC)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)c1cc2ccccc2n1C.O.[BH4-].[Li+]>>Cn1c(CO)cc2ccccc21",
        "output": "546"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.ClCCl.NC[C@H]1CN(c2ccc(N3CCC(n4ncnn4)CC3)c(F)c2)C(=O)O1>>CCOC(=O)NC[C@H]1CN(c2ccc(N3CCC(n4ncnn4)CC3)c(F)c2)C(=O)O1",
        "output": "94"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OC(C)=O.CN(C)c1ccncc1.ClCCl.O.OCCC1Cc2ccccc2C1.c1ccncc1>>CC(=O)OCCC1Cc2ccccc2C1",
        "output": "254"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.ClCCCBr.O=C([O-])[O-].Oc1ccc(-c2ccccc2)cc1.[K+].[K+]>>ClCCCOc1ccc(-c2ccccc2)cc1",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COC(=O)[C@@H]1CC[C@H](c2ccc(OCc3ccccc3)cc2)N1.O>>O=C(O)[C@@H]1CC[C@H](c2ccc(OCc3ccccc3)cc2)N1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCCc1cccc(Br)c1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>C=CCCc1cccc(B2OC(C)(C)C(C)(C)O2)c1",
        "output": "942"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC1=C(C(=O)OCc2ccccc2)N2C(=O)[C@@H](NC(=O)COc3ccccc3)[C@H]2SC1.COC1=CS[C@@H]2[C@H](NC(=O)COc3ccccc3)C(=O)N2[C@H]1C(=O)OCc1ccccc1.ClCCl.[Cl-].[K+].[Na+].[OH-]>>COC1=CS[C@@H]2[C@H](NC(=O)COc3ccccc3)C(=O)N2[C@H]1C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=O.COCCBr.Cc1ccc2ccc(O)c(C)c2n1.O.O=C([O-])[O-].[K+].[K+]>>COCCOc1ccc2ccc(C)nc2c1C",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C1=CCNCC1.CO.C[O-].ClCCl.O=C([O-])[O-].[K+].[K+].[Na+].[Na+].[OH-]>>O=C(O)C1=CCNCC1",
        "output": "122"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=C(Cn1nc(C(F)F)cc1C(F)F)N1CCC(c2nc(C3=NOC(c4ccccc4[N+](=O)[O-])C3)cs2)CC1.[Pd]>>Nc1ccccc1C1CC(c2csc(C3CCN(C(=O)Cn4nc(C(F)F)cc4C(F)F)CC3)n2)=NO1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cc1cc(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)c(C(=O)OC(C)(C)C)c2c3c(n(C)c12)CC1CCC3N1.[Pd]>>Cc1cc(S(=O)(=O)c2ccc(N)cc2)c(C(=O)OC(C)(C)C)c2c3c(n(C)c12)CC1CCC3N1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Fc1cccc(COc2ccc(Nc3ncnc4cccc(F)c34)cc2Cl)c1.OCCN1CCOCC1>>Fc1cccc(COc2ccc(Nc3ncnc4cccc(OCCN5CCOCC5)c34)cc2Cl)c1",
        "output": "958"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN=C=NCCCN(C)C.COc1ccc2c(c1)cc(C(=O)O)n2-c1ccccc1.Cl.ClCCl.Clc1cccc(N2CCNCC2)c1.O.On1nnc2ccccc21>>COc1ccc2c(c1)cc(C(=O)N1CCN(c3cccc(Cl)c3)CC1)n2-c1ccccc1",
        "output": "605"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCCCN1CCc2cc(C(=O)OC)c(C)c(NC(=O)C(C)(C)C)c21.CO.O.[Na+].[OH-]>>CCCCCCCCN1CCc2cc(C(=O)O)c(C)c(NC(=O)C(C)(C)C)c21",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Fc1ccnc(OCc2cn3cc(Br)cnc3n2)c1.OB(O)c1cccc(F)c1F>>Fc1ccnc(OCc2cn3cc(-c4cccc(F)c4F)cnc3n2)c1",
        "output": "871"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.Cc1cc(C)c(CNC(=O)c2csc(N3CCCC3C3CCN(C(=O)OC(C)(C)C)CC3)c2C)c(=O)[nH]1.Cl>>Cc1cc(C)c(CNC(=O)c2csc(N3CCCC3C3CCNCC3)c2C)c(=O)[nH]1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN[C@H](CN1CC[C@H](OCCOCCOCCOC(F)(F)F)C1)c1ccccc1.F[B-](F)(F)F.O=C(O)Cc1ccc(Cl)c(Cl)c1>>CN(C(=O)Cc1ccc(Cl)c(Cl)c1)[C@H](CN1CC[C@H](OCCOCCOCCOC(F)(F)F)C1)c1ccccc1",
        "output": "633"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCn1c(-c2ccc(O)cc2)c(C#N)c2ccc(OC)cc21.CN(C)C=O.COCCBr.O=C([O-])[O-].[K+].[K+]>>CCn1c(-c2ccc(OCCOC)cc2)c(C#N)c2ccc(OC)cc21",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1ccc2c(CCN)c[nH]c2c1.F[P-](F)(F)(F)(F)F.O=C(O)c1cc(Cc2cccc(F)c2)on1>>COc1ccc2c(CCNC(=O)c3cc(Cc4cccc(F)c4)on3)c[nH]c2c1",
        "output": "696"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.COC(=O)c1ccc(C2=CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC[C@@H]3[C@H]5[C@H](C(C)(O)CO)CC[C@]5(NC(=O)OCC5c6ccccc6-c6ccccc65)CC[C@]34C)C2(C)C)cc1.ClC(Cl)Cl.c1ccncc1>>COC(=O)c1ccc(C2=CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC[C@@H]3[C@H]5[C@H](C(C)(O)COC(C)=O)CC[C@]5(NC(=O)OCC5c6ccccc6-c6ccccc65)CC[C@]34C)C2(C)C)cc1",
        "output": "126"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)O.CC=C(C)C.COC(=O)C(O)(c1ccccc1)c1cccc(C=O)c1.O.[Na+].[O-][Cl+][O-]>>COC(=O)C(O)(c1ccccc1)c1cccc(C(=O)O)c1",
        "output": "384"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O=C(O)c1ccc(O)cc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1ccc(C(=O)O)cc1",
        "output": "746"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COc1ccc([N+](=O)[O-])c(C(=O)O)c1.[Pd]>>COc1ccc(N)c(C(=O)O)c1",
        "output": "202"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(Cc2ccc(Cn3cc(C)cn3)cc2)ccn1.O.[Li+].[OH-]>>Cc1cnn(Cc2ccc(Cc3ccnc(C(=O)O)c3)cc2)c1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.Cc1cccnc1N.O=C(CBr)c1ccc(I)cc1.O=C([O-])O.[Na+]>>Cc1cccn2cc(-c3ccc(I)cc3)nc12",
        "output": "508"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1c(C(F)(F)F)ncn(-c2ccc(F)cc2F)c1=O.O.O=S(=O)(O)O.O=[N+]([O-])O>>Cc1c(C(F)(F)F)ncn(-c2cc([N+](=O)[O-])c(F)cc2F)c1=O",
        "output": "21"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COCn1ccc(=O)c([N+](=O)[O-])c1Cl.NCC(F)(F)c1ccccn1>>COCn1ccc(=O)c([N+](=O)[O-])c1NCC(F)(F)c1ccccn1",
        "output": "70"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCN(CCN1CCNCC1)C1CCc2c(O)cccc2C1.Cl.Oc1ccc(CCl)c2cccnc12>>CCCN(CCN1CCN(Cc2ccc(O)c3ncccc23)CC1)C1CCc2c(O)cccc2C1",
        "output": "156"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.COC(=O)c1cc2c([nH]1)CCC2Cc1cccc(Cl)c1.[Li+].[OH-]>>O=C(O)c1cc2c([nH]1)CCC2Cc1cccc(Cl)c1",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.N#CCCCS(=O)(=O)c1cccc(Br)c1.O=C([O-])[O-].Oc1ccc(Cl)c(-c2ncnc3c(C(F)(F)F)cccc23)c1.[Cs+].[Cs+].[Cu]I>>N#CCCCS(=O)(=O)c1cccc(Oc2ccc(Cl)c(-c3ncnc4c(C(F)(F)F)cccc34)c2)c1",
        "output": "238"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)c1ccc2c(c1)C(C)(C)CC=C2c1ccccc1.CCO.Cl.O=Cc1ccc(C(=O)O)cc1.[Na+].[OH-]>>CC1(C)CC=C(c2ccccc2)c2ccc(C(=O)C=Cc3ccc(C(=O)O)cc3)cc21",
        "output": "295"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC1CCNCC1.CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)O)CC1>>CCOc1cc(C(C)(C)C)ncc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@@](C)(c2ccc(Cl)cc2)N1C(=O)N1CCC(CC(=O)N2CCC(OCC)CC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COCCn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)OC)ccc21.[Na+].[OH-]>>COCCn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)O)ccc21",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.COc1ccc2c(n1)C1(CO2)C(=O)N(Cc2ccc(C(F)(F)F)o2)c2ccccc21.C[Si](C)(C)Cl.O.[I-].[Na+]>>O=C1N(Cc2ccc(C(F)(F)F)o2)c2ccccc2C12COc1ccc(=O)[nH]c12",
        "output": "758"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCc1cc(C(OCOC)(C(F)(F)F)C(F)(F)F)ccc1Oc1ccc(NOCC)cc1.CCCc1cc(C(OCOC)(C(F)(F)F)C(F)(F)F)ccc1Oc1ccc([N+](=O)[O-])c(OCC)c1>>CCCc1cc(C(OCOC)(C(F)(F)F)C(F)(F)F)ccc1Oc1ccc(N)c(OCC)c1",
        "output": "335"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1c(CO)[nH]c2c(C)cccc12.ClCCl.[Mn+4].[O-2].[O-2]>>Cc1c(C=O)[nH]c2c(C)cccc12",
        "output": "263"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrBr.CC(=O)O.CC(=O)[O-].COC(=O)c1[nH]nc2c1CCc1cc(OC)ccc1-2.[Na+]>>COC(=O)c1[nH]nc2c1CCc1cc(OC)c(Br)cc1-2",
        "output": "98"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)CC1CCN(c2ccc(NC(=O)c3nnc(Nc4ccc(Oc5ccc(Cl)cc5)cc4)o3)cn2)CC1.O=C(Nc1ccc(N2CCC(C(=O)O)CC2)nc1)c1nnc(Nc2ccc(Oc3ccc(Cl)cc3)cc2)o1>>O=C(O)CC1CCN(c2ccc(NC(=O)c3nnc(Nc4ccc(Oc5ccc(Cl)cc5)cc4)o3)cn2)CC1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCCc1ccc(N)cc1.CCOC(=O)CCN=C=O.ClCCl>>CCCCCCCCc1ccc(NC(=O)NCCC(=O)OCC)cc1",
        "output": "176"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(N)cc1B1OC(C)(C)C(C)(C)O1.ClCCl.Cl[Pd]Cl.O=C([O-])[O-].OCCOc1ncc(Br)cc1N1CCOCC1.[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Cc1ccc(N)cc1-c1cnc(OCCO)c(N2CCOCC2)c1",
        "output": "938"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1nc(-c2cccc3c2OCO3)c(F)c(N)c1Cl.Cl.[Na+].[OH-]>>Nc1c(F)c(-c2cccc3c2OCO3)nc(C(=O)O)c1Cl",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)c1cc(Br)c(C(C)C)cc1N.CC(C)c1cc(N)c(C(C)C)c([N+](=O)[O-])c1Br.CC(C)c1cc(S(N)(=O)=O)c(C(C)C)c([N+](=O)[O-])c1Br.CC(C)c1ccc(C(C)C)c(N)c1.O=S=O>>CC(C)c1cc(S(N)(=O)=O)c(C(C)C)c(N)c1Br",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COc1cc(C=CC(=O)N[C@H]2CC[C@@H](C)CC2)ccc1OC(C)=O.Cl.O=C([O-])[O-].[Na+].[Na+]>>COc1cc(C=CC(=O)N[C@H]2CC[C@@H](C)CC2)ccc1O",
        "output": "22"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCNC(=O)OC1CCN(Cc2ccccc2)CC1.CCO.[Pd]>>CCCCNC(=O)OC1CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C1COCCO1.CC(C)(C)OC(=O)N1CCOC(c2ccc(Nc3ccc(Cl)cn3)cc2)C1.Cl.[Na+].[OH-]>>Clc1ccc(Nc2ccc(C3CNCCO3)cc2)nc1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.CCOC(C)=O.N#C[Cu].O=[N+]([O-])c1cc(Br)ccc1Br>>N#Cc1ccc(Br)cc1[N+](=O)[O-]",
        "output": "531"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCN(C(=O)OC(C)(C)C)c1ccc(N)nc1.COc1cc2ncnc(Oc3ccc(CC(=O)O)cc3)c2cc1OC>>CCCN(C(=O)OC(C)(C)C)c1ccc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)nc1",
        "output": "368"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(N)CC1.CCN(CC)CC.CS(C)=O.Cl.O.O=c1c2ccc(F)c(Br)c2nc(Cl)n1C1CC1>>CC1(Nc2nc3c(Br)c(F)ccc3c(=O)n2C2CC2)CC1",
        "output": "544"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)c1ccc(O)c(C)c1F.CCOC(=O)C(C)(C)Br.CN(C)C=O.O=C([O-])[O-].O=S(=O)([O-])O.[Cs+].[Cs+].[K+]>>CCOC(=O)C(C)(C)Oc1ccc(C(C)=O)c(F)c1C",
        "output": "305"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc(N2CCN[C@@H](Cc3ccccc3)C2)cc1OC(F)F.Cc1nc(CC(=O)O)n[nH]1>>COc1ccc(N2CCN(C(=O)Cc3n[nH]c(C)n3)[C@@H](Cc3ccccc3)C2)cc1OC(F)F",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(c2c[nH]c3ccc(C#N)cc23)CC1.CO.Cl>>N#Cc1ccc2[nH]cc(C3CCNCC3)c2c1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCNCC1.CN1CCOCC1.Cc1cc2ncc(-c3ccc(C#N)cc3)n2cc1-c1ccc(C(=O)O)cc1.F[P-](F)(F)(F)(F)F.O>>Cc1cc2ncc(-c3ccc(C#N)cc3)n2cc1-c1ccc(C(=O)N2CCN(C)CC2)cc1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1sc(N)nc1-c1ccccc1.O=C(O)c1cc(Cl)ccc1O>>CCOC(=O)c1sc(NC(=O)c2cc(Cl)ccc2O)nc1-c1ccccc1",
        "output": "918"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CCc1ccc(-c2nc(N)c3ccsc3n2)o1.O=C1CCC(=O)N1Br>>CCc1ccc(-c2nc(N)c3cc(Br)sc3n2)o1",
        "output": "807"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc(C(=O)N2CC[C@](CCOS(C)(=O)=O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC.O=C(O)C1(c2ccccc2)CCNCC1>>COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC",
        "output": "496"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)c1cc([N+](=O)[O-])c(C)cc1OC1CCN(C(=O)OC(C)(C)C)CC1.Cl>>Cc1cc(OC2CCN(C(=O)OC(C)(C)C)CC2)c(C(=O)O)cc1[N+](=O)[O-]",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cl.Cl[Sn]Cl.O.O.O=[N+]([O-])c1ccc(Cn2nc(C(F)(F)F)cc2C(F)(F)F)cc1.[Na+].[OH-]>>Nc1ccc(Cn2nc(C(F)(F)F)cc2C(F)(F)F)cc1",
        "output": "507"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CN(C)C=NC=[N+](C)C.ClP(Cl)(Cl)(Cl)Cl.NC=O.O=P(Cl)(Cl)Cl.Oc1ncnc2ccccc12.[Cl-].c1ccc2ncncc2c1>>Clc1ncnc2ccccc12",
        "output": "168"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OCn1c(=O)ccc2ccc(OCCCCCl)cc21.CN(C)C=O.Cl.O=C([O-])[O-].[Cl-].[I-].[K+].[K+].[NH4+].[Na+].c1cc(N2CCNCC2)c2ccsc2c1>>CC(=O)OCn1c(=O)ccc2ccc(OCCCCN3CCN(c4cccc5sccc45)CC3)cc21",
        "output": "138"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.O=C(Nc1ccc([N+](=O)[O-])cc1O)OCc1ccccc1.[H][H].[Ni]>>Nc1ccc(NC(=O)OCc2ccccc2)c(O)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1ccc2cc[nH]c2c1.C1CCOC1.COc1ccc(S(=O)(=O)Cl)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1.[H-].[Na+]>>COc1ccc(S(=O)(=O)n2ccc3ccc(Br)cc32)cc1N1CCN(C(=O)C(Cl)(Cl)Cl)CC1",
        "output": "648"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1cccc2oc(-c3nnc(C)o3)cc12>>Cc1nnc(-c2cc3c(O)cccc3o2)o1",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#Cc1ccccc1.CCN(CC)CC.Cc1ccnc(Br)c1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O.[Cu]I>>Cc1ccnc(C#Cc2ccccc2)c1",
        "output": "777"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CCN(C(=O)c2cccc(Nc3c(Cl)c(=O)c3=O)c2O)CC1.CS(C)=O.Nc1ccccc1Cl>>CN1CCN(C(=O)c2cccc(Nc3c(Nc4ccccc4Cl)c(=O)c3=O)c2O)CC1",
        "output": "510"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CNc1cccc(NC)n1.COc1ccc(OC)c(C2CCCC2CO)c1.CS(=O)(=O)Cl.ClCCl>>COc1ccc(OC)c(C2CCCC2COS(C)(=O)=O)c1",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.Nc1ccc(S(N)(=O)=O)cc1Cl.O=C(Br)CBr.O=C([O-])O.[Na+]>>NS(=O)(=O)c1ccc(NC(=O)CBr)c(Cl)c1",
        "output": "442"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NC(CCC(=O)O)C(=O)N1CCCC1C#N.CC(N)P(=O)(O)CC(Cc1ccccc1)C(=O)NCc1ccccc1.CCN=C=NCCCN(C)C.CCOC(C)=O.CN1CCOCC1.Cl.Cl.ClCCl.Oc1cccc2[nH]nnc12>>CC(NC(=O)CCC(NC(=O)OC(C)(C)C)C(=O)N1CCCC1C#N)P(=O)(O)CC(Cc1ccccc1)C(=O)NCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Clc1nc(Cl)nc(Cl)n1.Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(C(N)=O)(CC1)CC2>>Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(C#N)(CC1)CC2",
        "output": "172"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CC.CC(=O)[O-].CC(=O)[O-].CC(O)c1ccccc1.CC1CO1.N#Cc1ccccc1.O=C1c2ccccc2C(=O)N1O.O=O.[Co+2]>>CC(=O)c1ccccc1",
        "output": "32"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.Cc1ccnc(Nc2cccc(-c3cnc([C@H](C)N)s3)n2)c1.c1ccncc1>>CC(=O)N[C@@H](C)c1ncc(-c2cccc(Nc3cc(C)ccn3)n2)s1",
        "output": "339"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(C#Cc2ccc(C(OC)OC)cc2)cc1.CO.[Na+].[OH-]>>COC(OC)c1ccc(C#Cc2ccc(C(=O)O)cc2)cc1",
        "output": "5"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(CO)CNC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCN)c1=O.O=C(Cl)N1CCOCC1>>CC(C)(CO)CNC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(CCNC(=O)N2CCOCC2)c1=O",
        "output": "454"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)[Si](C)(C)O[C@@H]1CO[C@@H]2[C@@H](C#C[Si](C)(C)C)CO[C@H]12.CO.O=C([O-])[O-].[K+].[K+]>>C#C[C@H]1CO[C@@H]2[C@H](O[Si](C)(C)C(C)(C)C)CO[C@H]12",
        "output": "337"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(NC(=O)C(F)(F)F)c1ncc2sccn12.CCOC(C)=O.CO.[Na+].[OH-]>>CC(C)(N)c1ncc2sccn12",
        "output": "805"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(O)c1cnc2cc(N)ccc2c1.CCOC(C)=O.CN(C)C=O.Cc1cc(/C=C/C(F)(F)F)ccc1C(=O)O.ClCCl.O=C(Cl)C(=O)Cl.c1ccncc1>>Cc1cc(/C=C/C(F)(F)F)ccc1C(=O)Nc1ccc2cc(C(C)(C)O)cnc2c1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#CCOc1ccc(S(=O)(=O)N(C)C(CCCCl)C(=O)OC)cc1.CC(C)=O.[I-].[Na+]>>CC#CCOc1ccc(S(=O)(=O)N(C)C(CCCI)C(=O)OC)cc1",
        "output": "97"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(CC)CC.COC(=O)C1CCN(C(=O)OC)C(c2cc(F)c(F)cc2F)C1.COC(C)(C)C.O.[Br-].[Li+]>>COC(=O)N1CCC(C(=O)O)CC1c1cc(F)c(F)cc1F",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C1CCOC1.CCOC(=O)c1cn2c3c(cc(I)cc3c1=O)OCC2.CO.[Na+].[OH-]>>O=C(O)c1cn2c3c(cc(I)cc3c1=O)OCC2",
        "output": "171"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1(C)OB(c2cnc(N)nc2)OC1(C)C.OC1(c2cc3nc(Cl)nc(N4CCOCC4)c3s2)CCN(Cc2ccccn2)CC1>>Nc1ncc(-c2nc(N3CCOCC3)c3sc(C4(O)CCN(Cc5ccccn5)CC4)cc3n2)cn1",
        "output": "973"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.CN1CCCC2CNCC21.COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCCl.O=C([O-])[O-].[K+].[K+]>>COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CC2CCCN(C)C2C1",
        "output": "138"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.BrBr.CC(=O)O.CC(=O)c1cc(C#N)c(N)nc1C>>Cc1nc(N)c(C#N)cc1C(=O)CBr",
        "output": "173"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CCOP(=O)(C#N)OCC.CN(C)C=O.CNC.Cl.Cl.O=C(O)[C@H]1CN2CC[C@@H]1C(=O)C2C(c1ccccc1)c1ccccc1.O=C([O-])O.[Na+]>>CN(C)C(=O)[C@H]1CN2CC[C@@H]1C(=O)C2C(c1ccccc1)c1ccccc1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1noc(-c2ccc(Br)cc2)c1NC(C)CCc1c(F)cccc1Cl.Cl[Pd]Cl.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4NC(C)CCc4c(F)cccc4Cl)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccc(CCN2CCOCC2)cc1.C=CB1OC(C)(C)C(C)(C)O1.CC(C)(C)[P]([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C(C)(C)C)C(C)(C)C.CCN(CC)CC.Cc1ccccc1>>CC1(C)OB(/C=C/c2ccc(CCN3CCOCC3)cc2)OC1(C)C",
        "output": "539"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C1COCCO1.CCN=C=NCCCN(C)C.Cl.N.O.O=C(O)[C@@H]1CC[C@@H](Nc2ncc3nnn(-c4ccc(I)cc4)c3n2)C1.On1nnc2ccccc21>>NC(=O)[C@@H]1CC[C@@H](Nc2ncc3nnn(-c4ccc(I)cc4)c3n2)C1",
        "output": "313"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCCCCc1cnc(-c2ccc(C(=O)O)cc2)nc1.O=S(Cl)Cl>>CCCCCCCCCCc1cnc(-c2ccc(C(=O)Cl)cc2)nc1",
        "output": "3"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC2(CCNCC2)C1.CN(C)C=O.Cc1ccsc1C=O.[Na+].[Na+].[OH-]>>Cc1ccsc1CN1CCC2(CC1)CCN(C(=O)OC(C)(C)C)C2",
        "output": "792"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1CCC(N(C(=O)Nc2ncc(CN3CCN(S(=O)(=O)N(C)C)CC3)s2)C2CCNCC2)CC1.Cl.O=C(Cl)c1ccc(F)cc1>>CC1CCC(N(C(=O)Nc2ncc(CN3CCN(S(=O)(=O)N(C)C)CC3)s2)C2CCN(C(=O)c3ccc(F)cc3)CC2)CC1",
        "output": "201"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)N(C)[C@@H]1CC[C@H](N)[C@H](CC#N)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CO.F[B-](F)(F)F.O=C(O)CNC(=O)c1cccc(C(F)(F)F)c1>>CC(C)N(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CC#N)C1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.CS(=O)(=O)c1ccc(O)cc1.O.O=C([O-])[O-].O=[N+]([O-])c1cc(Cl)c(F)c(Cl)c1.[K+].[K+]>>CS(=O)(=O)c1ccc(Oc2c(Cl)cc([N+](=O)[O-])cc2Cl)cc1",
        "output": "564"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCn1c(NC)nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c2c1=O.Cn1ccc2c(-c3ccccc3)c(-c3ccc(C4(N)CCC4)cc3)oc2c1=O>>CCn1c(NC)nc2oc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)c2c1=O",
        "output": "793"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.C[C@H]1[C@H](NC(=O)OC(C)(C)C)C(=O)Nc2cc(Br)ccc2N1C(=O)CS(C)(=O)=O.[C-]#N.[C-]#N.[Zn+2]>>C[C@H]1[C@H](NC(=O)OC(C)(C)C)C(=O)Nc2cc(C#N)ccc2N1C(=O)CS(C)(=O)=O",
        "output": "65"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(C)nc1C.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1ccc(CO)c(C)n1",
        "output": "383"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.COC(=O)CBr.O=C(C=Cc1ccccc1)Nc1cccc(O)c1.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)COc1cccc(NC(=O)C=Cc2ccccc2)c1",
        "output": "557"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(=O)(=O)Cl.ClCCl.N#CC1CSCC1O.O>>CS(=O)(=O)OC1CSCC1C#N",
        "output": "0"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCC2=NCCCN2CC1.CC(C)(C)OC(=O)N1CCNCC1.CCO.Clc1cccc(CNc2cncc(Cl)n2)c1.O>>CC(C)(C)OC(=O)N1CCN(c2cncc(NCc3cccc(Cl)c3)n2)CC1",
        "output": "505"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NCCO.CCN(CC)CC.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCCNC(=O)OC(C)(C)C)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN1CCCC1=O.O=C(O)Cc1ccc(Cl)c(F)c1.OCc1ccccc1.[H-].[Na+]>>O=C(O)Cc1ccc(Cl)c(OCc2ccccc2)c1",
        "output": "485"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "N#CC(c1ccc(Cl)cc1)c1ccc(-n2ncc(=O)[nH]c2=O)cc1Cl.O.O=S(=O)(O)O>>NC(=O)C(c1ccc(Cl)cc1)c1ccc(-n2ncc(=O)[nH]c2=O)cc1Cl",
        "output": "8"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(C(C)C)C(C)C.CNCCCOc1ccc(-c2cc3c(ncn3C)c(C#N)n2)cc1C(F)(F)F>>CC(=O)N(C)CCCOc1ccc(-c2cc3c(ncn3C)c(C#N)n2)cc1C(F)(F)F",
        "output": "125"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCN(Cc1nc2cc(C(=O)NCCc3c[nH]cn3)ccc2[nH]1)C1CCCc2cccnc21.CN(Cc1nc2c(N)cccc2[nH]1)C1CCCc2cccnc21.O=C(O)c1ccncc1.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>>CN(Cc1nc2c(NC(=O)c3ccncc3)cccc2[nH]1)C1CCCc2cccnc21",
        "output": "759"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)C(=NOC)c3nsc(N)n3)[C@H]2SC1.CCOCC.COc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>C=CC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOC)c3nsc(N)n3)[C@H]2SC1",
        "output": "228"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C=CC(=O)Nc1cccc(-c2c(COC(C)=O)ccc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc23)c1.CCOC(C)=O.[Na+].[OH-]>>C=CC(=O)Nc1cccc(-c2c(CO)ccc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc23)c1",
        "output": "497"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CS(C)=O.Cc1c(N)ccc(O)c1C.N#Cc1cc2c(Cl)ccnc2cc1OCc1ccccc1.O.[H-].[Na+]>>Cc1c(N)ccc(Oc2ccnc3cc(OCc4ccccc4)c(C#N)cc23)c1C",
        "output": "351"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC.COC(=O)C(C)c1ccc2c(c1)CCC(C)(C)N2.O=C(Cl)c1ccccc1.c1ccncc1>>COC(=O)C(C)c1ccc2c(c1)CCC(C)(C)N2C(=O)c1ccccc1",
        "output": "614"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Clc1cccc(-c2nc(Cl)c3c(n2)CCC3)c1.Nc1ccc(Cc2ncco2)cc1>>Clc1cccc(-c2nc3c(c(Nc4ccc(Cc5ncco5)cc4)n2)CCC3)c1",
        "output": "161"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Cl.Cl[Sn]Cl.O=[N+]([O-])c1cc(OC(F)(F)F)ccc1S(=O)(=O)Nc1cccc2cccnc12>>Nc1cc(OC(F)(F)F)ccc1S(=O)(=O)Nc1cccc2cccnc12",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCn1c(C(=O)O)cc2c(F)cccc21.CN(C)c1ccncc1.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c([C@@H]3CCCNC3)cc12.ClCCl>>CCn1c(C(=O)N2CCC[C@@H](c3cc4c(C(=O)NC)c(-c5ccc(F)cc5)oc4cc3N(C)S(C)(=O)=O)C2)cc2c(F)cccc21",
        "output": "605"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)CN(CC(N)C(=O)OC(C)(C)C)C(=O)Cc1c[nH]c(=O)[nH]c1=O.Cl.[Na+].[OH-]>>CC(C)(C)OC(=O)C(N)CN(CC(=O)O)C(=O)Cc1c[nH]c(=O)[nH]c1=O",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.CCOC(=O)N1CCC(Nc2ccccc2)(C(=O)CC)CC1.[K+].[OH-]>>CCC(=O)C1(Nc2ccccc2)CCNCC1",
        "output": "283"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CCCc1ccc(C(=O)C[C@H](NC(=O)C(F)(F)F)C(=O)O)cc1.CCOC(C)=O.[H][H].[Pd]>>CCCc1ccc(CC[C@H](NC(=O)C(F)(F)F)C(=O)O)cc1",
        "output": "92"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.CC(=O)[O-].CCCc1c(COc2ccc(C=O)cc2)ccc(C(C)=O)c1OC.O=C1CSC(=S)N1.[Na+]>>CCCc1c(COc2ccc(C=C3SC(=S)NC3=O)cc2)ccc(C(C)=O)c1OC",
        "output": "314"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(CC)CC.Clc1ncc(Br)c(Cl)n1.NCCCCCNC(=O)OCc1ccccc1.O>>O=C(NCCCCCNc1nc(Cl)ncc1Br)OCc1ccccc1",
        "output": "110"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COCCOc1cc(/C=C/C(=O)OC)c([N+](=O)[O-])cc1Cl.Cl[Sn]Cl.O=C([O-])[O-].[Na+].[Na+]>>COCCOc1cc(/C=C/C(=O)OC)c(N)cc1Cl",
        "output": "202"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1ccc(OCCCCCOCC(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1ccc(OCCCCCOCC(=O)O)cc1",
        "output": "278"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN.Cc1cc([N+](=O)[O-])cc(C(=O)O)n1.Cl.Cl.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CNC(=O)c1cc([N+](=O)[O-])cc(C)n1",
        "output": "137"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.C1CCOC1.CCN(CC)CC.CN(C)C=O.ClCCl.F[P-](F)(F)(F)(F)F.NCc1ccccc1.O.O=C(O)c1cnc2[nH]ccc2c1>>O=C(NCc1ccccc1)c1cnc2[nH]ccc2c1",
        "output": "790"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN.CCOC(=O)c1c(C)nc2cccc(OCC(C)(C)C(=O)O)c2c1N.Cl>>CCNC(=O)C(C)(C)COc1cccc2nc(C)c(C(=O)OCC)c(N)c12",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)CN.CCCCCC.CCOC(C)=O.CO.Clc1ncc(Br)c(Cl)n1>>CC(C)CNc1nc(Cl)ncc1Br",
        "output": "110"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CS(C)=O.Cl.O=C(O)c1ccc(Cl)nc1.[K+].[OH-]>>CCOc1ccc(C(=O)O)cn1",
        "output": "433"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOc1ccc(C(CO)C(F)(F)F)cc1.Clc1ccc(Oc2cccc(CBr)c2)cc1.[H-].[Na+]>>CCOc1ccc(C(COCc2cccc(Oc3ccc(Cl)cc3)c2)C(F)(F)F)cc1",
        "output": "464"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#Cc1cnc2c(C)cc(OC(SC)C(=O)NC(C)(CO)COC)cc2c1.C1CCOC1.CI.[H-].[Na+]>>C#Cc1cnc2c(C)cc(OC(SC)C(=O)NC(C)(COC)COC)cc2c1",
        "output": "140"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)C(CC(C)C)N1C(=O)C(=O)c2ccccc21.O.O.[Li+].[OH-]>>CC(C)CC(C(=O)O)N1C(=O)C(=O)c2ccccc21",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.Cl.ClCCl.N#CCc1ccccc1N>>CS(=O)(=O)Nc1ccccc1CC#N",
        "output": "194"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)c1ccc(N)cc1.COc1cn(C(C)C(=O)O)c(=O)cc1Br>>COc1cn(C(C)C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)cc1Br",
        "output": "710"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)C=Cc1cnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2cc3cccc(C)c3nc2-c2cc(C(C)C)ccc2OC)nc1.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>COc1ccc(C(C)C)cc1-c1nc2c(C)cccc2cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ncc(C=CC(=O)O)cn1",
        "output": "58"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCN.CCOC(C)=O.CN(C)C=O.O.O=C(O)c1ccc(CNc2ccccc2C(=O)Nc2cc3ccccc3cn2)cn1.O=C(n1ccnc1)n1ccnc1>>CCCNC(=O)c1ccc(CNc2ccccc2C(=O)Nc2cc3ccccc3cn2)cn1",
        "output": "137"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Brc1ccc2c(c1)[nH]c1cc(Br)ccc12.CC(C)=O.CCCCC(CC)CBr.CCCC[N+](CCCC)(CCCC)CCCC.S.[Na+].[OH-]>>CCCCC(CC)Cn1c2cc(Br)ccc2c2ccc(Br)cc21",
        "output": "470"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)OB(c2ccc(S(=O)(=O)N3CCC4(CC3)CN(C3CC3)C(=O)CO4)cc2)OC1(C)C.Cn1ccc2c(Br)cccc21>>Cn1ccc2c(-c3ccc(S(=O)(=O)N4CCC5(CC4)CN(C4CC4)C(=O)CO5)cc3)cccc21",
        "output": "972"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NCCBr.CN(C)C=O.O=[N+]([O-])c1c(Br)n[nH]c1Br.[H-].[Na+]>>CC(C)(C)OC(=O)NCCn1nc(Br)c([N+](=O)[O-])c1Br",
        "output": "577"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCCCBr.CCCC[N+](CCCC)(CCCC)CCCC.ClC(Cl)Cl.O.[Br-].[Na+].[OH-].c1cn[nH]c1>>BrCCCn1cccn1",
        "output": "577"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CCO.COCCOC.CS(=O)(=O)O.NCCCCN.O.O=C(Cl)OCc1ccccc1.[K+]>>NCCCCNC(=O)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)c1nc(-c2ccc(O)cc2)n(C)c1C.CN(C)C=O.ClCC1CO1.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1nc(-c2ccc(OCC3CO3)cc2)n(C)c1C",
        "output": "15"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CC(=O)Cl.CCN(CC)CC.OCCCCCCBr.c1ccccc1>>C=CC(=O)OCCCCCCBr",
        "output": "320"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.CCn1c2ccccc2c2cc(C=C(c3ccccc3)c3ccccc3)ccc21.CN(C)C=O.Cc1ccccc1.O=P(Cl)(Cl)Cl.[Cl-].[Cl-].[Zn+2].c1ccccc1>>CCn1c2ccc(C=O)cc2c2cc(C=C(c3ccccc3)c3ccccc3)ccc21",
        "output": "239"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.NCc1ccc(F)cc1F.O=C(O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12>>O=C(NCc1ccc(F)cc1F)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12",
        "output": "753"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOCc1nc2c(N)nc3ccc(OCc4ccccc4)cc3c2n1CC(C)(C)NS(C)(=O)=O.CO.ClCCl.[H][H].[NH4+].[OH-].[Pd]>>CCOCc1nc2c(N)nc3ccc(O)cc3c2n1CC(C)(C)NS(C)(=O)=O",
        "output": "23"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCSC)C(=O)OC.CO.N>>CCC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCSC)C(N)=O",
        "output": "432"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n([C@@H]2CC[C@@H](N(C)C3CCOCC3)CC2)c2ncnn12.CCOC(C)=O.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n([C@@H]2CC[C@@H](N(C)C3CCOCC3)CC2)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CNOC.Cl.O=C(NCC(O)C(=O)O)c1cc2cc(Cl)ccc2[nH]1>>CON(C)C(=O)C(O)CNC(=O)c1cc2cc(Cl)ccc2[nH]1",
        "output": "54"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)OB(c2c(F)cc(C=O)cc2F)OC1(C)C.CCOC(C)=O.CO.[BH4-].[Na+]>>CC1(C)OB(c2c(F)cc(CO)cc2F)OC1(C)C",
        "output": "356"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.Cc1c[nH]c(C)c1.Cc1cc(C)c(S(=O)(=O)Cl)c(C)c1.[H-].[Na+]>>Cc1cc(C)c(S(=O)(=O)n2cc(C)cc2C)c(C)c1",
        "output": "648"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCCC.CCOC(=O)c1cc2cc(Br)ccc2[nH]1.CCOC(C)=O.CN(C)C=O.N#C[Cu]>>CCOC(=O)c1cc2cc(C#N)ccc2[nH]1",
        "output": "531"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COc1cc2c(-c3cc4cccnc4n3S(=O)(=O)c3ccc(C)cc3)cn(CCO)c2cc1OC.[K+].[OH-]>>COc1cc2c(-c3cc4cccnc4[nH]3)cn(CCO)c2cc1OC",
        "output": "949"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Cc1cc([N+](=O)[O-])ccc1[N+](=O)[O-].Cc1cc2ccc([N+](=O)[O-])cc2[nH]1.Cc1ccccc1.O=C=[Fe](=C=O)C1C=CC=C1.[C]=O>>Cc1cc2ccc(N)cc2[nH]1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CN1CCOCC1.Cc1cnn(CC[C@](C)(C(=O)O)S(C)(=O)=O)c1.NOC1CCCCO1.O>>Cc1cnn(CC[C@](C)(C(=O)NOC2CCCCO2)S(C)(=O)=O)c1",
        "output": "480"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CCCC[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)O.CCOC(C)=O.CN1CCOCC1.COC(=O)C12CC3CC(CC(N)(C3)C1C(=O)[C@H](Cc1ccccc1)NC(=O)CN)C2>>CCCC[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)C1C2(N)CC3CC(C2)CC1(C(=O)OC)C3",
        "output": "133"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(C)N.Cc1ccc(C(=O)N2CCC(c3ccc(-c4cnn(C)c4)cc3)CC2)cc1NC(=O)c1ccc(Cl)nc1>>Cc1ccc(C(=O)N2CCC(c3ccc(-c4cnn(C)c4)cc3)CC2)cc1NC(=O)c1ccc(NC(C)C)nc1",
        "output": "70"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(CC)CBr.CCO.NCCCCO>>CCC(CC)CNCCCCO",
        "output": "147"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@@H]1CO.CCN(C(C)C)C(C)C.CCOC(C)=O.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@@H]1C=O",
        "output": "610"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)C1(Sc2ccnc3ccc(-c4cccc(C(F)(F)F)c4)cc23)CCC1.CO.Cl.O.[Na+].[OH-]>>O=C(O)C1(Sc2ccnc3ccc(-c4cccc(C(F)(F)F)c4)cc23)CCC1",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCN1.COC(=O)c1ccc(C=O)c(-c2ccccc2)n1.ClCCl>>COC(=O)c1ccc(CN2CCOCC2)c(-c2ccccc2)n1",
        "output": "757"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C(=O)N2CCC(C(=O)NC(CCCc3ccccc3)CCCc3ccccc3)CC2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(NC(CCCc1ccccc1)CCCc1ccccc1)C1CCN(C(=O)C2CCNCC2)CC1",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COCC(=O)Cl.ClCCl.c1ccc(CN2CCNCC2)cc1>>COCC(=O)N1CCN(Cc2ccccc2)CC1",
        "output": "125"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCCc1ccc(CO)cc1.ClCCl.O=[Mn]=O>>CC(C)(C)OC(=O)NCCc1ccc(C=O)cc1",
        "output": "179"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(-c2cccc3cc4c(cc23)C(c2ccc(C)s2)=CCC4(C)C)cc1.CO.O.[Li+].[OH-]>>Cc1ccc(C2=CCC(C)(C)c3cc4cccc(-c5ccc(C(=O)O)cc5)c4cc32)s1",
        "output": "5"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=O.COc1ccc(C(C#N)(CCCNCCOc2ccccc2OC)C(C)C)cc1OC.O.O=C([O-])[O-].O=CO.[K+].[K+]>>COc1ccc(C(C#N)(CCCN(C)CCOc2ccccc2OC)C(C)C)cc1OC",
        "output": "217"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)C=O.ClCCl.O=C(O)[C@H]1CCCNC1>>CC(C)(C)OC(=O)N1CCC[C@H](C(=O)O)C1",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COC(=O)Cl.COC(=O)c1[nH]c2c(C)ccc(C)c2c1N.c1ccncc1>>COC(=O)Nc1c(C(=O)OC)[nH]c2c(C)ccc(C)c12",
        "output": "763"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1nc2c(c(=O)[nH]1)-c1ccc(Cl)cc1C(c1ccccc1)=NC2.ClCCl.O=P(Cl)(Cl)Cl>>Cc1nc(Cl)c2c(n1)CN=C(c1ccccc1)c1cc(Cl)ccc1-2",
        "output": "14"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CN(C)C=O.CN1CCC(CO)(c2ccc(F)cc2)CC1.ClCCCl.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cc(Br)cc2ccccc12>>CN1CCC(COC(=O)c2cc(Br)cc3ccccc23)(c2ccc(F)cc2)CC1",
        "output": "33"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.Cl.O=C(O)Cc1cccs1>>COC(=O)Cc1cccs1",
        "output": "17"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COCOCCc1ccc(OCc2ccccc2)c(C(=O)OC)c1.Cl.[Na+].[OH-]>>COCOCCc1ccc(OCc2ccccc2)c(C(=O)O)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1nc(C(=O)O)c(-c2ccc(F)cc2)s1.O=C(CC1CCCCN1)c1cc2ccccc2o1>>Cc1nc(C(=O)N2CCCCC2CC(=O)c2cc3ccccc3o2)c(-c2ccc(F)cc2)s1",
        "output": "747"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C1CCC(O)CC1.CCOC(C)=O.CCOCC.CN(C)C=O.Clc1ncc(Br)cn1.O=C([O-])O.[Na+]>>CCOC(=O)C1CCC(Oc2ncc(Br)cn2)CC1",
        "output": "37"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC(CC(=O)OCC)n1c(=O)n(Cc2csc3cccc(C)c23)c2ccccc21.CO.Cl.O.[Na+].[OH-]>>CCCC(CC(=O)O)n1c(=O)n(Cc2csc3cccc(C)c23)c2ccccc21",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2ccc(Cl)cc2)cc1[N+](=O)[O-].[Cl-].[NH4+].[Zn]>>CC(C)(C)OC(=O)Nc1ccc(-c2ccc(Cl)cc2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CNC.N#Cc1ccccc1S(=O)(=O)Cl>>CN(C)S(=O)(=O)c1ccccc1C#N",
        "output": "99"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CI.Cc1ccc(O)c(I)n1>>COc1ccc(C)nc1I",
        "output": "661"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1=C(C(=O)O)C(c2ccc(C(F)(F)F)cc2)CC(=O)N1.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Cc1cc(N)cc2cn[nH]c12.Cl.ClCCCl>>CC1=C(C(=O)Nc2cc(C)c3[nH]ncc3c2)C(c2ccc(C(F)(F)F)cc2)CC(=O)N1",
        "output": "170"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)Nc1c(I)c(NC(C)=O)c(I)c(C(=O)N(C)CC(=O)O)c1I.CN(C)C=O.O=[N+]([O-])c1ccccc1O>>CC(=O)Nc1c(I)c(NC(C)=O)c(I)c(C(=O)N(C)CC(=O)Oc2ccccc2[N+](=O)[O-])c1I",
        "output": "108"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(=O)CC1.CO.[K+].[OH-].c1cc2cc[nH]c2cn1>>CC(C)(C)OC(=O)N1CC=C(c2c[nH]c3cnccc23)CC1",
        "output": "607"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cc1cncc(-c2ccc(CN)cc2CN(Cc2ccccc2)C(=O)C2CC2)c1.CS(=O)(=O)Cl>>CCOC(=O)Cc1cncc(-c2ccc(CNS(C)(=O)=O)cc2CN(Cc2ccccc2)C(=O)C2CC2)c1",
        "output": "742"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCCCCCC(C)C.CCOCC.O=S(=O)([O-])O.[Al+3].[H-].[H-].[H-].[H-].[K+].[Li+]>>CC(C)CCCCCCCO",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)CBr.CC1CNCc2cc(S(N)(=O)=O)sc2S1(=O)=O.CCN(CC)CC.CN(C)C=O.O>>CC(C)CN1Cc2cc(S(N)(=O)=O)sc2S(=O)(=O)C(C)C1",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COC(=O)c1ccc(N)cc1.COc1ccc2c(c1)OCCn1c-2c(C2CCCCC2)c2ccc(C(=O)NC(C)(C)C(=O)O)cc21.ClC(Cl)Cl.O=C([O-])O.O=S(Cl)Cl.[Na+].c1ccncc1>>COC(=O)c1ccc(NC(=O)C(C)(C)NC(=O)c2ccc3c(C4CCCCC4)c4n(c3c2)CCOc2cc(OC)ccc2-4)cc1",
        "output": "710"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.C1COCCOCCOCCOCCO1.Nc1nc(Cl)cc(Cl)n1.OCC12CC3CC(CC(C3)C1)C2.[H-].[Na+]>>Nc1nc(Cl)cc(OCC23CC4CC(CC(C4)C2)C3)n1",
        "output": "653"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1Cc1nc2ccccn2c1C#Cc1cccc(C(F)(F)F)c1>>NCc1nc2ccccn2c1C#Cc1cccc(C(F)(F)F)c1",
        "output": "242"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CI.CN(C)C=O.O=C1CC2(CCC(n3cc(Br)cn3)CC2)CN1.[H-].[Na+]>>CN1CC2(CCC(n3cc(Br)cn3)CC2)CC1=O",
        "output": "83"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)[C@H](CSCc1ccccc1)NC(=O)c1cc(N2CCCCC2)nc(-c2ccc(-c3ccccc3)cc2)n1.[Li+].[OH-]>>O=C(N[C@@H](CSCc1ccccc1)C(=O)O)c1cc(N2CCCCC2)nc(-c2ccc(-c3ccccc3)cc2)n1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.CNC1C2CCC1CN(Cc1ccccc1)C2.COc1ccc(OC(CCCOS(C)(=O)=O)c2ccc(C#N)cc2)cc1OC.O=C([O-])[O-].[K+].[K+]>>COc1ccc(OC(CCCN(C)C2C3CCC2CN(Cc2ccccc2)C3)c2ccc(C#N)cc2)cc1OC",
        "output": "496"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1nc(C=Cc2ccccc2Cl)oc1C.[Na+].[OH-]>>Cc1oc(C=Cc2ccccc2Cl)nc1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCOC(=O)/C=C/c1cnc(N[C@@H]2CCNC2)c(Cl)c1.Cc1cccc(C=O)c1.ClCCl.O=C([O-])[O-].[K+].[K+].[Na+]>>CCOC(=O)/C=C/c1cnc(N[C@@H]2CCN(Cc3cccc(C)c3)C2)c(Cl)c1",
        "output": "567"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1cc2c(cc1C)[C@@H](N)CCS2.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1cc2c(cc1C)[C@@H](NC(=O)OC(C)(C)C)CCS2",
        "output": "686"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.CC(C)Sc1ccc(O)cc1.ClCCCBr.O.[Na+].[OH-]>>CC(C)Sc1ccc(OCCCCl)cc1",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC1(C)Cc2c(c(C(=O)O)cc3nc(Nc4ccccc4Cl)[nH]c23)O1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F.Nc1ccc(Cl)cc1>>CC1(C)Cc2c(c(C(=O)Nc3ccc(Cl)cc3)cc3nc(Nc4ccccc4Cl)[nH]c23)O1",
        "output": "50"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc(Oc2ccc(Cl)nn2)c1.O.[Na+].[OH-]>>O=C(O)c1cccc(Oc2ccc(Cl)nn2)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.Cl[Sn]Cl.Nc1cccc(Cl)c1Cl.O.O=N[O-].[Na+]>>NNc1cccc(Cl)c1Cl",
        "output": "109"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCCCCC.CCCCCCCC(=O)c1ccc(CCC(COC(C)=O)(COC(C)=O)NC(C)=O)cc1.CCO.[H][H].[Pd]>>CCCCCCCCc1ccc(CCC(COC(C)=O)(COC(C)=O)NC(C)=O)cc1",
        "output": "92"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(CCCOc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1)C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>CNCCCOc1ccc2c(-c3c(-c4ccccn4)nn4c3CCC4)ccnc2c1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNC1.CC(=O)N(C)C.CCN(C(C)C)C(C)C.Cc1ccc(C(=O)O)cc1-n1cnc2ccc(OCCCl)cc2c1=O.ClCCl.[N-]=C=O>>Cc1ccc(C(=O)O)cc1-n1cnc2ccc(OCCN3CCCC3)cc2c1=O",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.COc1cc(Nc2nc3c(c(Cc4ccccc4)n2)CNCC3)ccc1-n1cnc(C)c1.N#CCBr>>COc1cc(Nc2nc3c(c(Cc4ccccc4)n2)CN(CC#N)CC3)ccc1-n1cnc(C)c1",
        "output": "880"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(-c2ccc(OC)cc2)c2ncnn12.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(-c2ccc(OC)cc2)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.COc1ccccc1O.COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1.Cc1ccccc1.ClCC1CO1.O.[Br-].[Na+].[OH-]>>COc1ccccc1OCC1CO1",
        "output": "15"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(N)C1CC1.CCN(C(C)C)C(C)C.Cl.O=[N+]([O-])c1cnc(Cl)cc1Cl>>CC(Nc1cc(Cl)ncc1[N+](=O)[O-])C1CC1",
        "output": "78"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(=O)CC1.O=S(=O)(c1ccc(Cl)c(Cl)c1)C1CCNCC1>>CC(C)(C)OC(=O)N1CCC(N2CCC(S(=O)(=O)c3ccc(Cl)c(Cl)c3)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)O[C@@H](CC(N)=O)CC(=O)OCc1ccccc1.CCCCCC.CCOC(C)=O.ClCCl.[Pd]>>CC(C)(C)[Si](C)(C)O[C@@H](CC(N)=O)CC(=O)O",
        "output": "186"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Fc1cc2[nH]ncc2cc1Br.O=C=O.[Li]C(C)(C)C>>O=C(O)c1cc2cn[nH]c2cc1F",
        "output": "654"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)Nc1ccc(OCCN(Cc2ccccc2)CC(O)COc2ccc(NC(C)=O)cc2C)cc1.CC(=O)OC(C)=O.[Na+].[OH-].c1ccncc1>>CC(=O)Nc1ccc(OCCN(Cc2ccccc2)CC(COc2ccc(NC(C)=O)cc2C)OC(C)=O)cc1",
        "output": "254"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1nccs1.CCOC(=O)C1CCNCC1.ClCCl>>CCOC(=O)C1CCN(c2nccs2)CC1",
        "output": "657"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCCCc1ccccc1.CN(C)C=O.COc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCNCC1.O=C(O)C(F)(F)F.O=C([O-])[O-].[K+].[K+]>>COc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCc2ccccc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)c1ccccc1Nc1cc(-c2ccccc2)ccc1C(=O)OC(C)(C)C.O=C(O)C(F)(F)F>>CN(C)c1ccccc1Nc1cc(-c2ccccc2)ccc1C(=O)O",
        "output": "752"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cc2cccc([N+](=O)[O-])c2[nH]1.CCOC(C)=O.O.O=S([O-])S(=O)[O-].[Na+].[Na+]>>CCOC(=O)c1cc2cccc(N)c2[nH]1",
        "output": "269"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].COc1cc(Br)cc2[nH]ncc12.ClCCl.OB(O)c1ccc(OCc2ccccc2)c(F)c1.[Cu+2].c1ccncc1>>COc1cc(Br)cc2c1cnn2-c1ccc(OCc2ccccc2)c(F)c1",
        "output": "925"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(O)CN.CCCCc1noc(C)c1CCc1nc(C)c(C(=O)O)s1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[B-](F)(F)F>>CCCCc1noc(C)c1CCc1nc(C)c(C(=O)NCC(C)(C)O)s1",
        "output": "534"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)C(CC1CCCC1)c1ccc(S(C)(=O)=O)c(C#N)c1.[Li+].[OH-]>>CS(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)O)cc1C#N",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(C)=O.Fc1cc(-c2cccc(NCC3CCOCC3)n2)c(Cl)cn1.N[C@H]1CC[C@H](N)CC1.O>>N[C@@H]1CC[C@@H](Nc2cc(-c3cccc(NCC4CCOCC4)n3)c(Cl)cn2)CC1",
        "output": "810"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.OCCCCCOCc1ccccc1>>CS(=O)(=O)OCCCCCOCc1ccccc1",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.CSc1nc2ccc(CO)cc2o1.ClCCl.O=S(Cl)Cl>>CSc1nc2ccc(CCl)cc2o1",
        "output": "81"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCc1ccc(Br)cc1.CC(=O)c1ccc(O)cc1.CC(C)=O.O=C([O-])[O-].[K+].[K+]>>CC(=O)c1ccc(OCc2ccc(Br)cc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CNc1nc(Cl)ncc1C(F)(F)F.COc1cc(C(=O)N2CCOCC2)c(C)cc1N.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O=C([O-])O.[Na+]>>CNc1nc(Nc2cc(C)c(C(=O)N3CCOCC3)cc2OC)ncc1C(F)(F)F",
        "output": "941"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CSC(F)(F)C(O)(Cn1cncn1)c1ccc(F)cc1F.ClCCl.O.O=C(OO)c1cccc(Cl)c1>>CS(=O)C(F)(F)C(O)(Cn1cncn1)c1ccc(F)cc1F",
        "output": "13"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CC#N.Cn1cnc(Nc2nc(Cl)nc(NC(c3ccc(F)cc3)c3nccn3C)n2)c1>>Cn1cnc(Nc2nc(NC(c3ccc(F)cc3)c3nccn3C)nc(N3CCOCC3)n2)c1",
        "output": "214"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)c1ccc2c(c1)nc(Nc1cc(OC)cc(OC)c1)n2CCCN(C)CCc1ccccn1.O.[Li+].[OH-]>>COc1cc(Nc2nc3cc(C(=O)O)ccc3n2CCCN(C)CCc2ccccn2)cc(OC)c1",
        "output": "247"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CC(F)(c2ccc(C=O)cc2)C1.CCO.Cl.NO.O>>CC(C)(C)OC(=O)N1CC(F)(c2ccc(C=NO)cc2)C1",
        "output": "30"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C(=O)OCc1cc(S(=O)(=O)c2cccc(F)c2)ccc1C1CCN(C(=O)OC(C)(C)C)C1.ClCCl.O=C(O)C(F)(F)F>>CN(C)C(=O)OCc1cc(S(=O)(=O)c2cccc(F)c2)ccc1C1CCNC1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)C(C(=O)OC(C)(C)C)c1nc(Cl)ccc1[N+](=O)[O-].CCOC(=O)CC(=O)[O-].COCCN1CCC(O)CC1.O=C([O-])CC(=O)[O-].[H-].[Na+]>>CCOC(=O)C(C(=O)OC(C)(C)C)c1nc(OC2CCN(CCOC)CC2)ccc1[N+](=O)[O-]",
        "output": "433"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCc1ccc(C=O)cc1.O=C(O)CC(=O)O.c1ccncc1>>CCCc1ccc(C=CC(=O)O)cc1",
        "output": "12"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(CCCN)C(=O)OC(C)(C)C.N#Cc1ccc(-c2cnn(-c3ccc(C(=O)O)cn3)c2O)cc1>>CN(CCCNC(=O)c1ccc(-n2ncc(-c3ccc(C#N)cc3)c2O)nc1)C(=O)OC(C)(C)C",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)[C@@H](C)Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12.O.O[C@@H]1CCNC1>>C[C@@H](Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)C(=O)N1CC[C@@H](O)C1",
        "output": "227"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)C(C)c1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CN2C(=O)O[C@H](c3ccccc3)[C@@H]2C)c1.CO.[Li+].[OH-]>>COc1ccc(C(C)C(=O)O)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2ccccc2)[C@@H]1C",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cc1cc(C(=O)C(C)N2CCC(O)(c3ccc(F)cc3)CC2)ccc1O[Si](C(C)C)(C(C)C)C(C)C.[BH4-].[Na+]>>Cc1cc(C(O)C(C)N2CCC(O)(c3ccc(F)cc3)CC2)ccc1O[Si](C(C)C)(C(C)C)C(C)C",
        "output": "24"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)c1cc(B2OC(C)(C)C(C)(C)O2)ccc1OCC(=O)OCc1ccccc1.CCO.[C].[Pd]>>CC(C)c1cc(B2OC(C)(C)C(C)(C)O2)ccc1OCC(=O)O",
        "output": "186"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)CC(C)C.CNC.COc1cc(C=CC(=O)N[C@@H]2CC[C@@H](C)CC2)ccc1OCCCCCl>>COc1cc(C=CC(=O)N[C@@H]2CC[C@@H](C)CC2)ccc1OCCCCN(C)C",
        "output": "138"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN1CCN(c2nc3ccc(N)cc3nc2N2CCN(C)CC2)CC1.Cc1ccc(S(=O)(=O)Cl)cc1.ClC(Cl)Cl>>Cc1ccc(S(=O)(=O)Nc2ccc3nc(N4CCN(C)CC4)c(N4CCN(C)CC4)nc3c2)cc1",
        "output": "68"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)[O-].CC1CCCO1.CN(C)C=O.CS(C)=O.Cc1cc(C(=O)N[C@H]2CCCCCC=C[C@@H]3C[C@@]3(C(=O)O)NC(=O)[C@@H]3C[C@@H](O)CN3C2=O)no1.Fc1ccc2nc(C(F)(F)F)c(Cl)nc2c1.[K+]>>Cc1cc(C(=O)N[C@H]2CCCCCC=C[C@@H]3C[C@@]3(C(=O)O)NC(=O)[C@@H]3C[C@@H](Oc4nc5cc(F)ccc5nc4C(F)(F)F)CN3C2=O)no1",
        "output": "209"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=S)N1c1ccc(N)cc1.CCN(CC)CC.ClCCl>>CC(=O)Nc1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1",
        "output": "9"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccccc1.CN(C)c1ccncc1.Clc1ccnc2cc(I)sc12.Cn1c(NCc2ccccc2)ncc(-c2ccc(O)c(F)c2)c1=O>>Cn1c(NCc2ccccc2)ncc(-c2ccc(Oc3ccnc4cc(I)sc34)c(F)c2)c1=O",
        "output": "936"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1nc(-n2ccc(OCc3ccccc3)cc2=O)sc1C(=O)O.NCc1cc2ccccc2s1.On1nnc2ccccc21>>Cc1nc(-n2ccc(OCc3ccccc3)cc2=O)sc1C(=O)NCc1cc2ccccc2s1",
        "output": "534"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1c(N)cccc1C(F)(F)F.Cl.O.O=N[O-].[I-].[K+].[Na+].[Na+].[OH-]>>Cc1c(I)cccc1C(F)(F)F",
        "output": "200"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COCCN.Cc1nn(-c2c(F)cccc2C=O)cc1CN1CCC2(CC1)OCC(F)(F)c1cc(Cl)sc12.ClCCl>>COCCN=Cc1cccc(F)c1-n1cc(CN2CCC3(CC2)OCC(F)(F)c2cc(Cl)sc23)c(C)n1",
        "output": "52"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1c1cc(C)nn1CCCc1ccccc1.[Li+].[OH-]>>Cc1cc(N2C[C@H](S(=O)(=O)c3ccccc3Cl)C[C@H]2C(=O)O)n(CCCc2ccccc2)n1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCCCN.O=C=Nc1cccc(C(F)(F)F)c1>>CCCCNC(=O)Nc1cccc(C(F)(F)F)c1",
        "output": "35"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COC(=O)CCCCCCCBr.Cn1c(-c2ccccc2)c(-c2ccccc2)[nH]c1=O.[H-].[Na+]>>COC(=O)CCCCCCCn1c(-c2ccccc2)c(-c2ccccc2)n(C)c1=O",
        "output": "495"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CNC.COC1=C(OC)C(=O)C(Cc2ccc(C=CC(=O)O)cc2)=C(C)C1=O.Cl>>COC1=C(OC)C(=O)C(Cc2ccc(C=CC(=O)N(C)C)cc2)=C(C)C1=O",
        "output": "517"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COC(=O)Cc1csc2c1c(=O)n(C)c(=O)n2C.O.O=S(=O)(O)O>>Cn1c(=O)c2c(CC(=O)O)csc2n(C)c1=O",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1sc2nc(-c3ccno3)nc(Cl)c2c1Cl.NCCc1ccccc1>>Cc1sc2nc(-c3ccno3)nc(NCCc3ccccc3)c2c1Cl",
        "output": "723"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1(C)CCC(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(NCC5CN(C(=O)OC(C)(C)C)C5)c([N+](=O)[O-])c4)c(Oc4cnc5[nH]ccc5c4)c3)CC2)=C(c2ccc(Cl)cc2)C1.ClCCl.O=C(O)C(F)(F)F>>CC1(C)CCC(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(NCC5CNC5)c([N+](=O)[O-])c4)c(Oc4cnc5[nH]ccc5c4)c3)CC2)=C(c2ccc(Cl)cc2)C1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.CCC1(c2cccc(OC)c2)CCCCN(CCCO)C1=O.ClCCl>>CCC1(c2cccc(O)c2)CCCCN(CCCO)C1=O",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(CO)CO[Si](C)(C)C(C)(C)C.CCN(CC)CC.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)(C=O)CO[Si](C)(C)C(C)(C)C",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.COC(=O)Cc1cccc(OCCCBr)c1.C[C@@H](CN)c1ccccc1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>COC(=O)Cc1cccc(OCCCNC[C@H](C)c2ccccc2)c1",
        "output": "147"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C/C=C1/CC[C@H]2[C@@H](O)CCC[C@]12C.CC(=O)OC(C)=O.CCOCC.c1ccncc1>>C/C=C1/CC[C@H]2[C@@H](OC(C)=O)CCC[C@]12C",
        "output": "254"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN.N#Cc1c(Cl)nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c1-c1ccc(OCCO)cc1.O>>CCNc1nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c(-c2ccc(OCCO)cc2)c1C#N",
        "output": "70"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O=C(NC1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1)c1ccccc1.O=[Pt]>>Nc1ccc(CCN2CCC(NC(=O)c3ccccc3)CC2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCCCCCCCCCCCC(=O)[O-].ClCCl.O=C(O)C(F)(F)F>>CCCCCCCCCCCCCCCCC(=O)O",
        "output": "151"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1CCNCC1.c1cc2c(s1)CCC/C2=N\\OCC1CO1>>CN1CCN(CC(O)CO/N=C2\\CCCc3sccc32)CC1",
        "output": "76"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1cccc(CCCO)n1.CCOC(=O)/N=N/C(=O)OCC.CN(C)C=O.Cc1cc(-c2noc(C(F)(F)F)n2)cc(C)c1O.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(=O)c1cccc(CCCOc2c(C)cc(-c3noc(C(F)(F)F)n3)cc2C)n1",
        "output": "478"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C#N)N1CCN(C)CC1.CCOCC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CC(CN)N1CCN(C)CC1",
        "output": "246"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CC1(O)CCC2(CC1)OCCO2.Cl.O.O=C([O-])[O-].[Na+].[Na+]>>CC1(O)CCC(=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CN1CCN2c3ccccc3Cc3ccccc3C2C1.CO.[Na+].[OH-]>>O=C(O)CN1CCN2c3ccccc3Cc3ccccc3C2C1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Clc1ccc(OC2CCNCC2)cc1Cl.Clc1nc2ccccc2[nH]1>>Clc1ccc(OC2CCN(c3nc4ccccc4[nH]3)CC2)cc1Cl",
        "output": "36"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CNC(=O)[C@@H]1C[C@@H](Oc2cc3c(Nc4cccc(Cl)c4F)ncnc3cc2OC)CCN1C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CNC(=O)[C@@H]1C[C@@H](Oc2cc3c(Nc4cccc(Cl)c4F)ncnc3cc2OC)CCN1",
        "output": "634"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.COC(=O)Cl.Clc1nc2c(c(N3CCOCC3)n1)CNC2.O=C(O)C(F)(F)F.[Na+].[OH-]>>COC(=O)N1Cc2nc(Cl)nc(N3CCOCC3)c2C1",
        "output": "219"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CN(C)C=O.CNCCc1ccncc1.O=S(=O)(Cl)C1CCCCC1.[H-].[Na+]>>CN(CCc1ccncc1)S(=O)(=O)C1CCCCC1",
        "output": "584"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#Cc1ccc(OC(F)F)c(C2CC2)c1.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Fc1ccc(Br)cc1OCC(F)F.[Cu]I>>Fc1ccc(C#Cc2ccc(OC(F)F)c(C3CC3)c2)cc1OCC(F)F",
        "output": "659"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C[C@H]1CN(c2cncc(N)c2)C[C@@H](C)N1.O=S(=O)(Cl)c1ccc(Br)c(F)c1.O=S(=O)(Nc1ccnc(Cl)c1)c1ccc(Br)cc1>>C[C@H]1CN(c2cncc(NS(=O)(=O)c3ccc(Br)c(F)c3)c2)C[C@@H](C)N1",
        "output": "554"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@@H]1COc1ccc(O)cc1.ClCc1cc2c(cc1Cl)OCO2>>CC(C)(C)OC(=O)N1CCC[C@@H]1COc1ccc(OCc2cc3c(cc2Cl)OCO3)cc1",
        "output": "49"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1csc(-c2cocn2)c1.[Na+].[OH-]>>O=C(O)c1csc(-c2cocn2)c1",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.Cc1ccccc1CN1CCC(=O)CC1.O=c1[nH]c2ccccc2n1C1CCNCC1.[BH3-]C#N.[Cl-].[Cl-].[Na+].[Zn+2]>>Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COc1ccc2nc(Nc3cc(Cc4ccccc4)nc(SC)n3)sc2c1.ClCCl.O.O=S([O-])OO.[K+]>>COc1ccc2nc(Nc3cc(Cc4ccccc4)nc(S(C)(=O)=O)n3)sc2c1",
        "output": "840"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.Cc1cc(F)ccc1-c1nc(NCC(=O)O)nc2c1ccc(=O)n2-c1c(F)cccc1F.Cl.F[P-](F)(F)(F)(F)F.OC1CNC1>>Cc1cc(F)ccc1-c1nc(NCC(=O)N2CC(O)C2)nc2c1ccc(=O)n2-c1c(F)cccc1F",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCO.N#Cc1ccc(C#N)cc1.[Na+].[OH-]>>N#Cc1ccc(C(N)=O)cc1",
        "output": "419"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.CN1CCCC[C@H]1c1nnc2ccc(F)cn12.N[C@H]1CC[C@@H](O)c2ccccc21.[H-].[Na+]>>CN1CCCC[C@H]1c1nnc2ccc(O[C@@H]3CC[C@H](N)c4ccccc43)cn12",
        "output": "823"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1cccnc1C.ClCCl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.[Na+]>>CCc1ccc[n+]([O-])c1C",
        "output": "262"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.ClCCl.FC1(F)CNC1.O.O=C(Cl)c1ccccc1Br.O=C([O-])[O-].[K+].[K+]>>O=C(c1ccccc1Br)N1CC(F)(F)C1",
        "output": "201"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CCN1CCOCC1.C[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)O.NC1CCCCCCC1>>C[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NC1CCCCCCC1",
        "output": "216"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Nc1nc(CCc2ccc(CBr)cc2)cs1.CC(C)(C)OC(=O)N1CCNCC1.CCOC(C)=O.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CC(=O)Nc1nc(CCc2ccc(CN3CCN(C(=O)OC(C)(C)C)CC3)cc2)cs1",
        "output": "248"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.CC(=O)[C@H]1[C@H](C)C[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@@]21C.CO.O>>C[C@@H]1C[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]2(C)[C@H]1C(=O)CBr",
        "output": "173"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCCCCC(=O)O.CCCNc1ccc(C#N)cc1N.CCN=C=NCCCN(C)C.Cl.ClC(Cl)Cl.On1nnc2ccccc21>>CCCNc1ccc(C#N)cc1NC(=O)CCCCNC(=O)OC(C)(C)C",
        "output": "365"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(C)(C(=O)O)CC1.CCOC(C)=O.CN(C)C=O.ClCCCl.Nc1cccc(-c2cnco2)c1.O=C(Cl)C(=O)Cl.c1ccncc1>>CC(C)(C)OC(=O)N1CCC(C)(C(=O)Nc2cccc(-c3cnco3)c2)CC1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.CCN(C(C)C)C(C)C.CCOC[C@H](NC(=O)OC(C)(C)C)C(=O)O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClCCl.F[B-](F)(F)F>>CCOC[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCOCC1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=C(C)c1cc(-c2ccc(C(F)(F)F)cc2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)c(OC)cc1F.CN(C)C=O.[Cl-].[Li+].[Na+].[OH-]>>C=C(C)c1cc(-c2ccc(C(F)(F)F)cc2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)c(O)cc1F",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.Cc1cc(C#N)ccc1Br.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1cc(CN)ccc1Br",
        "output": "175"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COc1cc(Br)c(F)cc1[N+](=O)[O-].O.O=S([O-])S(=O)[O-].[Na+].[Na+]>>COc1cc(Br)c(F)cc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.Cl.NO.O=C(c1ccccc1)c1ccccc1.c1ccncc1>>ON=C(c1ccccc1)c1ccccc1",
        "output": "190"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CN1CCCC1=O.Cc1cc(F)ccc1[N+](=O)[O-].NC(CO)CO>>Cc1cc(NC(CO)CO)ccc1[N+](=O)[O-]",
        "output": "572"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Cc1cc(C(=O)O)ccc1Br.O=C1CCCC1.[Li]CCCC.[Na+].[OH-]>>Cc1cc(C(=O)O)ccc1C1(O)CCCC1",
        "output": "321"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C1CCNCC1.CS(C)=O.Fc1cc(Br)ccn1.O.O=C([O-])[O-].[K+].[K+]>>CN(C)C1CCN(c2cc(Br)ccn2)CC1",
        "output": "756"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(Cc1ccc(OCc2ccccc2)cc1)C(=O)O.CCOCCO>>CCOCCOC(=O)C(Cc1ccc(OCc2ccccc2)cc1)OCC",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1cc(N2CCCC2)cc(N2CCCC2=O)c1.[Na+].[OH-]>>O=C(O)c1cc(N2CCCC2)cc(N2CCCC2=O)c1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CO.ClCCl.O.O=S(=O)(Cl)c1ccccc1.c1cc2c(cnn2CC2CCNCC2)cc1-c1cnn(C2CCCCO2)c1>>O=S(=O)(c1ccccc1)N1CCC(Cn2ncc3cc(-c4cnn(C5CCCCO5)c4)ccc32)CC1",
        "output": "99"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN1CCCC1=O.COc1ccc(N)cn1.O=C(Cl)Oc1ccccc1.O=C([O-])[O-].[K+].[K+]>>COc1ccc(NC(=O)Oc2ccccc2)cn1",
        "output": "763"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)CCN.COc1ccnc2c1ccc1nc3cccc(C(=O)O)c3nc12>>COc1ccnc2c1ccc1nc3cccc(C(=O)NCCN(C)C)c3nc12",
        "output": "674"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNCC1.CC(C)CNC(=O)/C=C/C=C/c1ccc2c(c1)OCO2.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C(O)CCc1ccc2c(c1)OCO2>>O=C(CCc1ccc2c(c1)OCO2)N1CCCCC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(/C=C/c2nc(-c3ccc(Cl)cc3Cl)cn2CC(=O)O)cc1.Nc1ccncc1>>COc1ccc(/C=C/c2nc(-c3ccc(Cl)cc3Cl)cn2CC(=O)Nc2ccncc2)cc1",
        "output": "365"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCC1(C2CCCCC2)CN(C(=O)[C@H](N)Cc2ccc(OC)cc2)C1.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[B-](F)(F)F.O=C(O)CCc1c[nH]cn1>>CCCCCC1(C2CCCCC2)CN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)CCc2c[nH]cn2)C1",
        "output": "133"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CCN(CC)CC.CCOC(=O)[C@@H](Cc1ccccc1CN)Oc1ncnc2sc(-c3ccco3)c(-c3ccc(OCCN4CCN(C)CC4)c(Cl)c3C)c12.ClCCl>>CCOC(=O)[C@@H](Cc1ccccc1CNC(C)=O)Oc1ncnc2sc(-c3ccco3)c(-c3ccc(OCCN4CCN(C)CC4)c(Cl)c3C)c12",
        "output": "206"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C1CCOC1.CN.Cc1nn(Cc2cnc(Cl)c(C(=O)O)c2)c(C)c1-c1ccc(C#N)c(Cl)c1.O.O=C(n1ccnc1)n1ccnc1.[Cl-].[Na+]>>CNC(=O)c1cc(Cn2nc(C)c(-c3ccc(C#N)c(Cl)c3)c2C)cnc1Cl",
        "output": "674"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCO.COc1cc2c(cc1Cl)CCN(C)CC2c1cc([N+](=O)[O-])cc2c1OCC2.[Cl-].[NH4+].[Na+].[Na+].[S-2]>>COc1cc2c(cc1Cl)CCN(C)CC2c1cc(N)cc2c1OCC2",
        "output": "202"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cc(Nc2cc3c(C)cccc3c(Cl)n2)n[nH]1.Cc1ccc(O)cc1>>Cc1ccc(Oc2nc(Nc3cc(C)[nH]n3)cc3c(C)cccc23)cc1",
        "output": "516"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNc1nc(Cl)nc(Cl)n1.O=C(O)C1CCNCC1.[Na+].[OH-]>>CNc1nc(Cl)nc(N2CCC(C(=O)O)CC2)n1",
        "output": "214"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=O.CCN(CC)CC.CN(C)c1cccc2c(S(=O)(=O)Cl)cccc12.NCCCC(=O)O.O.O=C([O-])O.[Na+]>>CN(C)c1cccc2c(S(=O)(=O)NCCCC(=O)O)cccc12",
        "output": "43"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.ClCCl.O=C(NCCc1ccccc1)C(F)(F)F.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)c1ccc(CCNC(=O)C(F)(F)F)cc1",
        "output": "31"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCCCCC(O)c1ccc(Br)cc1.CCOCC.CN(C)C=O.c1c[nH]cn1>>CCCCCC(O[Si](C)(C)C(C)(C)C)c1ccc(Br)cc1",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)[C@@H](NC(=O)c1ccc(-c2ccc(F)c(F)c2)cc1N)[C@@H](C)OC1CCC1.Cc1cc(C)c(N=C=O)c(C)c1.c1ccncc1>>COC(=O)[C@@H](NC(=O)c1ccc(-c2ccc(F)c(F)c2)cc1NC(=O)Nc1c(C)cc(C)cc1C)[C@@H](C)OC1CCC1",
        "output": "993"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)O.CC=C(C)C.O.O=Cc1c(C2CC2)cc(C(F)(F)F)cc1C(F)(F)F.O=P([O-])(O)O.[Na+].[Na+].[O-][Cl+][O-]>>O=C(O)c1c(C2CC2)cc(C(F)(F)F)cc1C(F)(F)F",
        "output": "384"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cccc(-c2ccccc2OC(F)(F)F)c1.O=C(O)c1cc2cccc(OC(F)(F)F)c2oc1=O>>O=C(Nc1cccc(-c2ccccc2OC(F)(F)F)c1)c1cc2cccc(OC(F)(F)F)c2oc1=O",
        "output": "799"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.O=[N+]([O-])c1ccc2c(Cl)nnc(Cl)c2c1.[Cl-].[Fe].[NH4+]>>Nc1ccc2c(Cl)nnc(Cl)c2c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCO.Cl.N[C@@H]1CCOc2c(F)cccc21.Nc1nc(Cl)c(N)c(Cl)n1.O=C([O-])O.[Na+]>>Nc1nc(Cl)c(N)c(N[C@@H]2CCOc3c(F)cccc32)n1",
        "output": "165"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)CCN(C)C(=O)c1ccc(NC(c2oc3ccc(F)cc3c2OC)C2CCCCC2)cc1.[Na+].[OH-]>>COc1c(C(Nc2ccc(C(=O)N(C)CCC(=O)O)cc2)C2CCCCC2)oc2ccc(F)cc12",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COC(=O)Cc1cnc(NS(=O)(=O)c2cccc(Cl)c2C)s1.[K+].[OH-]>>Cc1c(Cl)cccc1S(=O)(=O)Nc1ncc(CC(=O)O)s1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C(=C1CCNCC1)c1nc(-c2ccccc2)no1.CC(C)(C)OC(=O)N1CCC(=Cc2nc(-c3cccc(Cl)c3)no2)CC1>>Clc1cccc(-c2noc(C=C3CCNCC3)n2)c1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.Cc1cc([N+](=O)[O-])ccc1NC(=O)c1ccccc1.Cl[Sn]Cl.N>>Cc1cc(N)ccc1NC(=O)c1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)O)cc3)oc12.NCC1COc2ccccc2OC1>>CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NCC4COc5ccccc5OC4)cc3)oc12",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)Nc1cccc(Oc2ccc([N+](=O)[O-])c(N)c2)c1.CO.[C].[Pd]>>CC(C)(C)OC(=O)Nc1cccc(Oc2ccc(N)c(N)c2)c1",
        "output": "335"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1ccc([Se]c2cc3c(cc2OCCCCCO[Si](C)(C)C(C)(C)C)C(C)(C)CCC3(C)C)nc1.[Na+].[OH-]>>CC1(C)CCC(C)(C)c2cc([Se]c3ccc(C(=O)O)cn3)c(OCCCCCO[Si](C)(C)C(C)(C)C)cc21",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cn1nc(-c2cnc(N)nc2)cc1-c1ccc2[nH]c(-c3c(F)cccc3F)cc2c1.Cn1nc(-c2ncco2)cc1-c1ccc2c(c1)cc(-c1c(F)cccc1F)n2S(=O)(=O)c1ccccc1>>Cn1nc(-c2ncco2)cc1-c1ccc2[nH]c(-c3c(F)cccc3F)cc2c1",
        "output": "771"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.COc1cc(OCc2ccccc2)cc(-n2cc(C)nc2-c2ccncc2C)c1[N+](=O)[O-].Cl.Cl[Sn]Cl.O.O.[Na+].[OH-]>>COc1cc(OCc2ccccc2)cc(-n2cc(C)nc2-c2ccncc2C)c1N",
        "output": "202"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.COc1ncc(C(C)(O)C(F)(F)F)cc1-c1cnc(S(C)(=O)=O)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C.Cl.FC1CNC1.O=C(O)CC(O)(CC(=O)O)C(=O)O>>COc1ncc(C(C)(O)C(F)(F)F)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C",
        "output": "679"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(CC)CC.COCC(=O)Cl.Cl.NCCc1ccsc1>>COCC(=O)NCCc1ccsc1",
        "output": "45"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCC(C2(C)Cc3cc(Cl)ncc3O2)CC1.CC(C)(C)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CS(=O)(=O)N1CCNCC1.Cc1ccccc1.Cl.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[K+].[Pd].[Pd]>>CC(C)(C)OC(=O)N1CCC(C2(C)Cc3cc(N4CCN(S(C)(=O)=O)CC4)ncc3O2)CC1",
        "output": "220"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](C)(C)OC[C@H](Oc1ccc(Cl)cn1)[C@H]1CNC[C@@H]1c1ccc(F)c(F)c1.Cc1cc(C(=O)O)cnn1>>Cc1cc(C(=O)N2C[C@H]([C@H](CO[Si](C)(C)C(C)(C)C)Oc3ccc(Cl)cn3)[C@@H](c3ccc(F)c(F)c3)C2)cnn1",
        "output": "256"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cccc(N=C=O)c1CCl.ClCCl.OCc1ccccn1>>Cc1cccc(NC(=O)OCc2ccccn2)c1CCl",
        "output": "34"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C1CCNCC1.COc1ccccc1Sc1ccc(/C=C/C(=O)O)c(C(F)(F)F)c1Cl.ClCCl>>CCOC(=O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccccc3OC)c(Cl)c2C(F)(F)F)CC1",
        "output": "811"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC[C@H](C)Oc1cc(C(=O)OC)cc(C(=O)OC)c1.[K+].[OH-]>>COC[C@H](C)Oc1cc(C(=O)O)cc(C(=O)OC)c1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)c1ccc(C=O)c(OCC2CC2)c1.O.[Li+].[OH-]>>O=Cc1ccc(C(=O)O)cc1OCC1CC1",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOc1cc(C(CC(=O)O)N2C(=O)c3ccc(O)cc3C2=O)ccc1OC.Cl.NO.O=C(n1ccnc1)n1ccnc1>>CCOc1cc(C(CC(=O)NO)N2C(=O)c3ccc(O)cc3C2=O)ccc1OC",
        "output": "480"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CO.O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCC2(CCNC2)C1.O=C1Cc2ccccc2C1.[BH3-]C#N.[Na+]>>O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCC2(CCN(C3Cc4ccccc4C3)C2)C1",
        "output": "187"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCc1nc(C2CC2)n(-c2ccccc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCCc1nc(C2CC2)n(-c2ccccc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(O)(c1cn(Cc2ccn3c(-c4ccc(OC)nc4)c(C(N)=O)cc3c2)nn1)C(F)(F)F.CCOC(C)=O.Cc1ccccc1.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Na+].[Na+]>>CCC(O)(c1cn(Cc2ccn3c(-c4ccc(OC)nc4)c(C#N)cc3c2)nn1)C(F)(F)F",
        "output": "624"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(CO)C(=O)O.CCN=C=NCCCN(C)C.CN(C)C=O.ClCCl.NCCNS(=O)(=O)c1ccccc1[N+](=O)[O-].On1nnc2ccccc21>>CC(C)(CO)C(=O)NCCNS(=O)(=O)c1ccccc1[N+](=O)[O-]",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C=O.COc1c(N)cc(C(C)(C)C)cc1NS(C)(=O)=O.Cc1ccc(C(=O)O)cc1N=[N+]=[N-].ClCCl.O=C(Cl)C(=O)Cl>>COc1c(NC(=O)c2ccc(C)c(N=[N+]=[N-])c2)cc(C(C)(C)C)cc1NS(C)(=O)=O",
        "output": "50"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CC#N.COc1cc(Br)c(C=O)cc1O.O.O=C([O-])[O-].[K+].[K+]>>COc1cc(Br)c(C=O)cc1OCc1ccccc1",
        "output": "127"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.O.O=N[O-].O=S(=O)(Nc1cc(F)ccc1F)c1ccccc1.O=[N+]([O-])O.[Na+]>>O=[N+]([O-])c1cc(F)c(NS(=O)(=O)c2ccccc2)cc1F",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.O.O=Cc1ccc(C2OCCO2)cn1.[BH4-].[Na+]>>OCc1ccc(C2OCCO2)cn1",
        "output": "745"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CI.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1O.[K+].[K+]>>COc1cc(F)ccc1[N+](=O)[O-]",
        "output": "62"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](Oc2ccccc2C(F)(F)F)C1.ClCCl.O=C(O)C(F)(F)F>>FC(F)(F)c1ccccc1O[C@H]1CCNC1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CC(C)=O.COC(=O)c1c(O)c2cc(OC)ccc2n1-c1ccccc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1c(OCc2ccccc2)c2cc(OC)ccc2n1-c1ccccc1",
        "output": "623"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)NCCC(NC(=O)OC(C)(C)C)c1ccc(Cl)cc1.O=C(O)C(F)(F)F>>CC(=O)NCCC(N)c1ccc(Cl)cc1",
        "output": "793"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CN1CCN(c2ccc(N)cc2)CC1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccccc23)cc1.Cl>>CN1CCN(c2ccc(Nc3nc4ccccc4c4c[nH]nc34)cc2)CC1",
        "output": "998"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.Cc1cc([N+](=O)[O-])c(F)cc1Cl.[H][H].[Pt]>>Cc1cc(N)c(F)cc1Cl",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CO.Nc1ccc(OC(F)(F)F)cc1C(=O)O.O.O=S(=O)(O)O>>COC(=O)c1cc(OC(F)(F)F)ccc1N",
        "output": "195"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.Cc1cc(C(=O)N[C@@H](CCCCN)c2nc3cc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1.O=C1CC(C(=O)O)CN1>>Cc1cc(C(=O)N[C@@H](CCCCNC(=O)C2CNC(=O)C2)c2nc3cc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CNC.O=C1COc2ccc(C3=Cc4ccc(C(=O)O)cc4SC3c3ccccc3)cc2N1>>CN(C)C(=O)c1ccc2c(c1)SC(c1ccccc1)C(c1ccc3c(c1)NC(=O)CO3)=C2",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.Fc1cccc2c1OCCO2.O=C1CCC(=O)N1Br>>Fc1cc(Br)cc2c1OCCO2",
        "output": "4"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)Cl.Cl.OCC(F)(F)C(F)F.c1ccncc1>>COC(=O)OCC(F)(F)C(F)F",
        "output": "144"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=CCOC(=O)CCCCCCCCBr.CCCCCc1ccc(-c2ccc(CC(O)C3CCC(CCC)CC3)cc2)cc1.Cc1ccccc1.[H-].[H][H].[Na+]>>C=CCOC(=O)CCCCCCCCOC(Cc1ccc(-c2ccc(CCCCC)cc2)cc1)C1CCC(CCC)CC1",
        "output": "95"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)C1CN(CC)C(=O)C1=O.ClCCl.O.[Li+].[OH-]>>CCN1CC(C(=O)O)C(=O)C1=O",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N(CC1CC1)C[C@@H](C(=O)O)c1ccc(Cl)cc1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.C[C@@H]1C[C@H](O)c2ncnc(N3CCNCC3)c21.Cl.Cl.ClCCl.F[P-](F)(F)(F)(F)F>>C[C@@H]1C[C@H](O)c2ncnc(N3CCN(C(=O)[C@H](CN(CC4CC4)C(=O)OC(C)(C)C)c4ccc(Cl)cc4)CC3)c21",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CCc1cc(F)c(OCc2c(-c3ccc4c(c3)CCO4)csc2C(F)(F)F)c(F)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCc1cc(F)c(OCc2c(-c3ccc4c(c3)CCO4)csc2C(F)(F)F)c(F)c1",
        "output": "225"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCC(C)CC(=O)O.CN(C)C=O.Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(N3CCNCC3)nc2)cc1.ClCCl.N=C=N.O.On1nnc2ccccc21>>CCC(C)CC(=O)N1CCN(c2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)cn2)CC1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrBr.CC(=O)c1cccc2nnsc12.ClC(Cl)Cl>>O=C(CBr)c1cccc2nnsc12",
        "output": "173"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C(=O)Cc1ccc(F)cc1)C1CNCC1c1ccc(Cl)c(Cl)c1.O=C(O)c1ccc(N2CCOCC2)nc1>>CN(C(=O)Cc1ccc(F)cc1)C1CN(C(=O)c2ccc(N3CCOCC3)nc2)CC1c1ccc(Cl)c(Cl)c1",
        "output": "256"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)CCCCc1cc2cc(C#N)ccc2c(=O)n1-c1ccc(F)cc1.CO.Cl.ClCCl.NO.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)CCCCc1cc2cc(C(N)=NO)ccc2c(=O)n1-c1ccc(F)cc1",
        "output": "400"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(C(C)C)C(C)C.FC1(F)CCN(c2cc(C3CNC3)cc(Nc3cc(C(F)(F)F)ccn3)n2)C1.O=C1COC1.[Na+]>>FC1(F)CCN(c2cc(C3CN(C4COC4)C3)cc(Nc3cc(C(F)(F)F)ccn3)n2)C1",
        "output": "983"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1CCn2c(Cc3ccccc3-c3ccccc3)nc(=O)c(O)c2C1=O.CN1CCn2c(Cc3ccccc3-c3ccccc3Cl)nc(=O)c(OCc3ccccc3)c2C1=O>>CN1CCn2c(Cc3ccccc3-c3ccccc3Cl)nc(=O)c(O)c2C1=O",
        "output": "492"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(N)c1.O=C(Cl)CCCl>>COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(NC(=O)CCCl)c1",
        "output": "9"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCCC.COB(OC)OC.Cl.Fc1c(Cl)cccc1Br.[Li]CCCC>>OB(O)c1cccc(Cl)c1F",
        "output": "789"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCO.CN(C)C(On1nnc2ccccc21)=[N+](C)C.C[C@H](N)c1nc2cc(Br)ccc2[nH]1.ClBr.ClCCl.F[B-](F)(F)F.O=C(O)c1ccc(C(=O)N2CC=CC2)c(Br)c1>>C[C@H](NC(=O)c1ccc(C(=O)N2CC=CC2)c(Br)c1)c1nc2cc(Br)ccc2[nH]1",
        "output": "902"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1nc(-c2cn3c(n2)-c2cc(SC4CCN(C(C)(C)C(N)=O)CC4)c(F)cc2OCC3)n(C(C)C)n1.ClCCl.O=C(O)C(F)(F)F.O=C(OO)c1cccc(Cl)c1>>Cc1nc(-c2cn3c(n2)-c2cc(S(=O)C4CCN(C(C)(C)C(N)=O)CC4)c(F)cc2OCC3)n(C(C)C)n1",
        "output": "500"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCNC(=O)Nc1nc2cc(-c3cnc(N4CCC(C)(C(=O)OCC)CC4)nc3)cc(Br)c2s1.CCO.Cl.[Na+].[OH-]>>CCNC(=O)Nc1nc2cc(-c3cnc(N4CCC(C)(C(=O)O)CC4)nc3)cc(Br)c2s1",
        "output": "281"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CCOc1ccc(C[C@H](OC(C)C)C(=O)OC)cc1.ClCCl.II.O.O=S(=O)([O-])[O-].O=S([O-])([O-])=S.[Ag+2].[Na+].[Na+]>>CCOc1ccc(C[C@H](OC(C)C)C(=O)OC)cc1I",
        "output": "372"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.Cc1c(NCCO)cccc1[N+](=O)[O-].[H][H].[Ni]>>Cc1c(N)cccc1NCCO",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cc1ccc(-n2cc(-c3nc(C)cs3)nc2-c2ccc(Nc3ncccc3[N+](=O)[O-])cc2)cn1.[H][H].[Pd]>>Cc1ccc(-n2cc(-c3nc(C)cs3)nc2-c2ccc(Nc3ncccc3N)cc2)cn1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)C(Cc1ccccc1)Cc1ccccc1.[Na+].[OH-]>>O=C(O)C(Cc1ccccc1)Cc1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCCCCCCCCCCCCO.O=C(Cl)c1ccccc1I>>CCCCCCCCCCCCCCCCCCOC(=O)c1ccccc1I",
        "output": "51"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1c(Br)nn(C)c1N1CC[C@@H](O)C1.CI.CN(C)C=O.O.[H-].[Na+]>>CCOC(=O)c1c(Br)nn(C)c1N1CC[C@@H](OC)C1",
        "output": "140"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(CCN2C(=O)c3ccccc3C2=O)CC1.NCCO.O>>CC(C)(C)OC(=O)N1CCC(CCN)CC1",
        "output": "242"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "ClCCl.O=S(Cl)Cl.OCc1ccc(CC2CCOC2)nc1>>ClCc1ccc(CC2CCOC2)nc1",
        "output": "477"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Nc1cccc(B(O)O)c1.COC(=O)c1ccc(NS(=O)(=O)c2cccc(Br)c2)cc1O>>COC(=O)c1ccc(NS(=O)(=O)c2cccc(-c3cccc(NC(C)=O)c3)c2)cc1O",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCCNCC1.CCN(CC)CC.O=c1[nH]cc(S(=O)(=O)Cl)c2cc(Br)ccc12>>CC(C)(C)OC(=O)N1CCCN(S(=O)(=O)c2c[nH]c(=O)c3ccc(Br)cc23)CC1",
        "output": "169"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1ccc(C=O)cc1.ClCCl.O=C([O-])O.O=c1c2[nH]nc(C3CCCC3)c2nc2n1CCNC2.[Na+].[Na+]>>COc1ccc(CN2CCn3c(nc4c(C5CCCC5)n[nH]c4c3=O)C2)cc1",
        "output": "567"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOCC.CN(C)C=O.Cl.ClCc1ccccn1.O.O=C(Nc1c(F)cccc1F)c1ccc(Cc2cc(Cl)ccc2O)o1.O=C([O-])[O-].[K+].[K+]>>O=C(Nc1c(F)cccc1F)c1ccc(Cc2cc(Cl)ccc2OCc2ccccn2)o1",
        "output": "616"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "B.C1CCOC1.CSC.O=C(O)Cc1ccc([N+](=O)[O-])c(F)c1>>O=[N+]([O-])c1ccc(CCO)cc1F",
        "output": "231"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(C)=O.Cc1c(Cl)ccc2c1[nH]c1c(C(=O)O)cccc12.Cl.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1c(Cl)ccc2c1[nH]c1c(CO)cccc12",
        "output": "293"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)[O-].C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.O.O=C1CCC2(CC1)OCCO2.[Br-].[K+]>>C=C1CCC2(CC1)OCCO2",
        "output": "601"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(=O)C1CCNC1.ClCCl>>CCOC(=O)C1CCN(C(=O)OC(C)(C)C)C1",
        "output": "694"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.C1CCOC1.CC(=O)O.CCCC[N+](CCCC)(CCCC)CCCC.Cc1cnc2c(c1)NC(=O)CN2C(=O)NC(c1ccc(OC(F)(F)F)cc1)C(C)(C)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C.O.[Cl-].[F-].[Na+]>>Cc1cnc2c(c1)NC(=O)CN2C(=O)NC(c1ccc(OC(F)(F)F)cc1)C(C)(C)CO",
        "output": "781"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1cc(C#N)c2nc(C(=O)OC)cc(O)c2c1.COC(=O)c1cc(O)c2cccc(OCc3ccccc3)c2n1>>CCc1cc(C#N)c2nc(C(=O)O)cc(O)c2c1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCC.Cc1cc(F)ccc1Br.O=C=O.[Li]CCCC>>Cc1cc(F)ccc1C(=O)O",
        "output": "654"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[O-].CCC(O)c1cc(Cl)c2c(c1Cl)C(=O)N(Cc1c(C)cc(C)nc1OCc1ccccc1)CC2.CI.CN(C)C=O.[K+]>>CCC(OC)c1cc(Cl)c2c(c1Cl)C(=O)N(Cc1c(C)cc(C)nc1OCc1ccccc1)CC2",
        "output": "140"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCc1ccccc1.Cc1[nH]c2ccccc2c1Sc1cccc(CC(=O)O)c1>>Cc1c(Sc2cccc(CC(=O)O)c2)c2ccccc2n1Cc1ccccc1",
        "output": "528"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cl.N#Cc1ccc(N)cc1.O=N[O-].[Na+]>>N#Cc1ccc(NN)cc1",
        "output": "109"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.COC(=O)c1cn2c(n1)COc1ccc([N+](=O)[O-])cc1-2.Cl.[Na+].[OH-]>>COC(=O)c1cn2c(n1)COc1ccc(N)cc1-2",
        "output": "202"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC2CNCC21.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O.O=C(O)c1ccccc1-c1ccccc1>>CC(C)(C)OC(=O)N1CC2CN(C(=O)c3ccccc3-c3ccccc3)CC21",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.COc1cc2ncnc(Oc3ccc(N)cc3)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.OCCc1cccc(C(F)(F)F)c1>>COc1cc2ncnc(Oc3ccc(NC(=O)OCCc4cccc(C(F)(F)F)c4)cc3)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.N.N#Cc1ccccc1-n1ccnc1.[Ni]>>NCc1ccccc1-n1ccnc1",
        "output": "175"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(F)c(N(C)c2ccnc(Cl)n2)c1.Nc1cc(N2CCOCC2)cc(N2CCOCC2)c1>>COc1ccc(F)c(N(C)c2ccnc(Nc3cc(N4CCOCC4)cc(N4CCOCC4)c3)n2)c1",
        "output": "808"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CN(C)C=O.CO.COC(=O)c1c(NC(=O)c2ccc(C)cc2)csc1-c1ccc(C)cc1.O.[Li+].[OH-]>>Cc1ccc(C(=O)Nc2csc(-c3ccc(C)cc3)c2C(=O)O)cc1",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)c1cccc(C(C)C)c1NC(=O)CBr.O=S(=O)(O)O.O=[N+]([O-])O>>CC(C)c1ccc([N+](=O)[O-])c(C(C)C)c1NC(=O)CBr",
        "output": "21"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cc(-c3nnco3)cc(-c3ccnc(NC4CCCCC4)c3)n2)CC1.ClCCl.O=C(O)C(F)(F)F>>c1cc(-c2cc(-c3nnco3)cc(N3CCNCC3)n2)cc(NC2CCCCC2)n1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2c(C=O)c3ccccc3n2-c2ccc(-c3ccncc3)cc2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=Cc1c(N2CCNCC2)n(-c2ccc(-c3ccncc3)cc2)c2ccccc12",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)OC(C)C.CCOC(=O)C(CC(=O)OC(C)(C)C)(Cc1cn(C)c2ccccc12)C(=O)OCC.ClCCl.O=C(O)C(F)(F)F>>CCOC(=O)C(CC(=O)O)(Cc1cn(C)c2ccccc12)C(=O)OCC",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Nc1ccccn1.O=C(O)C(SC1CCCC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>O=C(Nc1ccccn1)C(SC1CCCC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "368"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.N#Cc1ccc(CNC2CCCCC2)cc1>>CC(C)(C)OC(=O)N(Cc1ccc(C#N)cc1)C1CCCCC1",
        "output": "867"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.CO.ClCCl.O=C(Cl)C(=O)Cl.O=Cc1cccc(C(=O)O)c1O>>COC(=O)c1cccc(C=O)c1O",
        "output": "195"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.Clc1cccc(N2CCNCC2)c1.O=C(CCl)CN1CCC(C(Oc2cccc(F)c2)c2ccccc2)CC1.O=C([O-])[O-].[K+].[K+]>>O=C(CN1CCC(C(Oc2cccc(F)c2)c2ccccc2)CC1)CN1CCN(c2cccc(Cl)c2)CC1",
        "output": "414"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=C(Cl)c1cccc(C(=O)Cl)c1.O=C=NCCCCCCN=C=O.OCC(F)(F)F>>O=C=NCCCCCCNC(=O)OCC(F)(F)F",
        "output": "235"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.COC(=O)[C@@H](N)Cc1ccc(-c2c(C)n(C)c(=O)n(C)c2=O)cc1.COCCC1(C(=O)O)CCCC1.Cl.F[P-](F)(F)(F)(F)F>>COCCC1(C(=O)N[C@@H](Cc2ccc(-c3c(C)n(C)c(=O)n(C)c3=O)cc2)C(=O)OC)CCCC1",
        "output": "129"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COc1ccc(COc2ccc(Sc3ccc(O)cc3)c([N+](=O)[O-])c2)cc1.O.[Cl-].[Fe].[NH4+]>>COc1ccc(COc2ccc(Sc3ccc(O)cc3)c(N)c2)cc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CN(C)C=O.Cl.O=C(CCl)c1ccc2c(c1)CCCC2.O=C(NC1CCNCC1)c1ccccc1>>O=C(CN1CCC(NC(=O)c2ccccc2)CC1)c1ccc2c(c1)CCCC2",
        "output": "414"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCC.Cc1cc(C(=O)O)cc(Cl)n1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1cc(CO)cc(Cl)n1",
        "output": "72"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(Cl)CCl.Cc1ccc(S(=O)(=O)Cl)cc1.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>O=S(=O)(Cl)c1ccc(CBr)cc1",
        "output": "29"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.N[C@H]1CCCNC(=O)C1.O.O=C(Cl)OCc1ccccc1>>O=C1C[C@@H](NC(=O)OCc2ccccc2)CCCN1",
        "output": "479"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CCCCCn1c(=O)n(CCCc2cccc(Br)c2)c(=O)c2[nH]c(Cl)nc21.CN(C)CC(=O)O.Cl.O=C([O-])[O-].Oc1ccccc1.[Cs+].[Cs+].[Cu]I>>CCCCCn1c(=O)n(CCCc2cccc(Oc3ccccc3)c2)c(=O)c2[nH]c(Cl)nc21",
        "output": "238"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)COc1cccc2c1CCCCC2NS(=O)(=O)c1ccc(-c2ccc(O)cc2)cc1.[Na+].[OH-]>>O=C(O)COc1cccc2c1CCCCC2NS(=O)(=O)c1ccc(-c2ccc(O)cc2)cc1",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCO.CCN(CC)CC.COc1cc2nc(N3CCNCC3)nc(N)c2cc1OC.Cl.Clc1nc2ccccc2[nH]1>>COc1cc2nc(N3CCN(c4nc5ccccc5[nH]4)CC3)nc(N)c2cc1OC",
        "output": "36"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)C[Al+]CC(C)C.CCOC(=O)C=Cc1cccc(OCc2nc(-c3ccccc3)oc2C)c1.Cc1ccccc1.Cl.ClCCl.[H-]>>Cc1oc(-c2ccccc2)nc1COc1cccc(/C=C/CO)c1",
        "output": "150"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1onc(-c2ccccn2)c1CCc1ncc(C(=O)O)s1.NCCO>>Cc1onc(-c2ccccn2)c1CCc1ncc(C(=O)NCCO)s1",
        "output": "534"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cl.Cl.Nc1cc(Br)c(O)c(Br)c1.O.O=N[O-].[I-].[K+].[Na+]>>Oc1c(Br)cc(I)cc1Br",
        "output": "200"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CNC.Cl.N#Cc1cncc(C#Cc2ccc(F)c(C(=O)O)c2)c1.O.On1nnc2ccccc21>>CN(C)C(=O)c1cc(C#Cc2cncc(C#N)c2)ccc1F",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(C[C@@H](CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc(C)c1OCc1ccccc1.ClCCl.[H][H].[Pd]>>Cc1cc(C[C@@H](CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc(C)c1O",
        "output": "23"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.O=C(O)c1ccccc1CC[C@]1(O)CCC2=Cc3c(cnn3-c3ccc(F)cc3)C[C@@]21C1CC1.[Al+3].[Cl-].[H-].[H-].[H-].[H-].[Li+].[NH4+]>>OCc1ccccc1CC[C@]1(O)CCC2=Cc3c(cnn3-c3ccc(F)cc3)C[C@@]21C1CC1",
        "output": "72"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCc1ccc(OCC2CO2)cc1.O=C1C(=O)c2ccccc2C2=C1SCC1(CCNCC1)O2>>CCc1ccc(OCC(O)CN2CCC3(CC2)CSC2=C(O3)c3ccccc3C(=O)C2=O)cc1",
        "output": "76"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.C[Si](C)(C)Cl.ClCCl.Oc1ccc(F)cc1F>>C[Si](C)(C)Oc1ccc(F)cc1F",
        "output": "746"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COc1ccc(C(=O)O)cc1Cl.ClC(Cl)Cl.O=C(Cl)C(=O)Cl>>COc1ccc(C(=O)Cl)cc1Cl",
        "output": "448"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1ccc(-c2cc3ccccc3[nH]2)cc1N.ClCCl.O=C([O-])O.O=Cc1cccc([N+](=O)[O-])c1.[Na+].[Na+]>>COc1ccc(-c2cc3ccccc3[nH]2)cc1NCc1cccc([N+](=O)[O-])c1",
        "output": "359"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)Nc1ccccc1N.CCN(CC)CC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.O=Cc1ccc(C(=O)O)s1>>CC(C)(C)OC(=O)Nc1ccccc1NC(=O)c1ccc(C=O)s1",
        "output": "822"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O[C@@H]1CC[C@@H]1Oc1ccccc1C(F)(F)F>>CS(=O)(=O)O[C@@H]1CC[C@@H]1Oc1ccccc1C(F)(F)F",
        "output": "0"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCC(CN)(C(=O)NCc2cc3ccccc3[nH]2)CC1.CO.Cl>>NCC1(C(=O)NCc2cc3ccccc3[nH]2)CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)[C@@H]1CC[C@@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1.CN(C)C=O.ClCCl.Cl[SiH](Cl)Cl.Nc1ccccc1>>CC(Nc1ccccc1)[C@@H]1CC[C@@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1",
        "output": "469"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CI.CN(C(=O)OC(C)(C)C)[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc(C#CCCCO)cc21.[H-].[Na+]>>COCCCC#Cc1ccc2c(c1)[C@@H](N(C)C(=O)OC(C)(C)C)CC[C@H]2c1ccc(Cl)c(Cl)c1",
        "output": "140"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=Cc1ccc(O)cc1.OCCCCc1ccc(F)cc1>>O=Cc1ccc(OCCCCc2ccc(F)cc2)cc1",
        "output": "478"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC1(C)CCC(C(=O)N2CCCC2)NC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC1(C)CCC(CN2CCCC2)NC1",
        "output": "490"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCC(OC2CCNCC2)C1.CC(=O)N(C)C.CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F>>O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCC(OC2CCCC2)CC1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCC1CC1.CN(C)C=O.C[Si](C)(C)CCS(=O)(=O)n1cc(C2CCN(S(=O)(=O)N3CCNC[C@@H]3C(=O)NOCc3ccccc3)CC2)c2cc(F)ccc21.O.O=C([O-])[O-].[K+].[K+]>>C[Si](C)(C)CCS(=O)(=O)n1cc(C2CCN(S(=O)(=O)N3CCN(CC4CC4)C[C@@H]3C(=O)NOCc3ccccc3)CC2)c2cc(F)ccc21",
        "output": "73"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)CC.COCC(=O)Cl.ClCCl.N[C@@H]1CCCN(Cc2ccccc2)C1.O>>COCC(=O)N[C@@H]1CCCN(Cc2ccccc2)C1",
        "output": "45"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CN(C)C=O.O=C(O)c1cccc(-n2cccn2)c1.O=S(Cl)Cl.[NH4+].c1ccccc1>>NC(=O)c1cccc(-n2cccn2)c1",
        "output": "358"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CC(=O)O.CCCc1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CCCCN4)n4ccnc(N)c34)cc2F)c1>>C=CC(=O)N1CCCC[C@H]1c1nc(-c2ccc(C(=O)Nc3cc(CCC)ccn3)c(F)c2)c2c(N)nccn12",
        "output": "517"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "B.C1CCOC1.COc1cc(C(=O)O)cc(OC)c1Br.CSC.O>>COc1cc(CO)cc(OC)c1Br",
        "output": "72"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)C(C)Oc1ccc(OCCn2c(=O)sc3cc(C(=O)c4ccccc4)ccc32)cc1.CON>>CCOC(=O)C(C)Oc1ccc(OCCn2c(=O)sc3cc(C(=NOC)c4ccccc4)ccc32)cc1",
        "output": "190"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCCC.CN(C)C=O.FC(F)(F)c1ccccc1Cl.O.[Li]CCCC>>O=Cc1cccc(C(F)(F)F)c1Cl",
        "output": "239"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC1CCc2ccc(CN)cc2C1Cc1ccccc1.CCN(CC)CC.ClCCl.O=S(=O)(Cl)CC1CC1>>CC(C)(C)OC(=O)NC1CCc2ccc(CNS(=O)(=O)CC3CC3)cc2C1Cc1ccccc1",
        "output": "742"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Clc1ccc2ccccc2n1.NC1CCCC(N)C1>>NC1CCCC(Nc2ccc3ccccc3n2)C1",
        "output": "70"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)N(C)C.CN(C)C=O.Cc1cc(C(=O)O)n(-c2ccccc2)n1.Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1.O=C(Cl)C(=O)Cl>>Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)n(-c2ccccc2)n1",
        "output": "844"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC1=C(OC)C(=O)C(CCCCCCCCCCCCOC(C)=O)=C(C)C1=O.Cl.O=C([O-])O.[Na+]>>COC1=C(OC)C(=O)C(CCCCCCCCCCCCO)=C(C)C1=O",
        "output": "225"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CC(N2CCOCC2)CCN1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O=C(O)Cn1cc(NC(=O)c2cnn3cccnc23)c(-c2cc(Cl)ccc2OC(F)F)n1>>O=C(Nc1cn(CC(=O)N2CCC(N3CCOCC3)CC2)nc1-c1cc(Cl)ccc1OC(F)F)c1cnn2cccnc12",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCOC(=O)Nc1cccc(-c2nc(C(C)(C)C)sc2-c2ccnc(Cl)n2)c1F.CO.N>>C=CCOC(=O)Nc1cccc(-c2nc(C(C)(C)C)sc2-c2ccnc(N)n2)c1F",
        "output": "312"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O=C(O)c1ccc(Cl)nc1.O=C([O-])[O-].OB(O)c1ccc(C(F)(F)F)cc1.[Na+].[Na+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(O)c1ccc(-c2ccc(C(F)(F)F)cc2)nc1",
        "output": "865"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C(CCl)c1ccccc1.O=Cc1ccccc1>>OC(CCl)c1ccccc1",
        "output": "24"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.CCO.Cc1ccccc1.Nc1ccc(Oc2ccnc(NC(=O)N3CCC(N4CCC(O)CC4)CC3)c2)cc1.O=C(Cc1ccc(F)cc1)N=C=S>>O=C(Cc1ccc(F)cc1)NC(=S)Nc1ccc(Oc2ccnc(NC(=O)N3CCC(N4CCC(O)CC4)CC3)c2)cc1",
        "output": "961"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)[O-].C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.ClCCl.O=Cc1ccc(N(c2ccccc2)c2ccccc2)cc1.[Br-].[K+]>>C=Cc1ccc(N(c2ccccc2)c2ccccc2)cc1",
        "output": "649"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)C[C@@H]1COc2cc(OCc3cccc(-c4c(C)cc(OC5CCN(C(=O)OC(C)(C)C)CC5)cc4C)c3)ccc21.[Na+].[OH-]>>Cc1cc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "N[C@@H](c1ccccn1)C(F)(F)F.O=C(O)c1cnc(C2CC2)c(OCC2CC2)n1>>O=C(N[C@@H](c1ccccn1)C(F)(F)F)c1cnc(C2CC2)c(OCC2CC2)n1",
        "output": "697"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.O.O=[Pt].O=c1c2cnn(-c3ccc([N+](=O)[O-])cc3)c2nc(-c2ccc(Cl)cc2Cl)n1-c1ccc(Cl)cc1.[H][H]>>Nc1ccc(-n2ncc3c(=O)n(-c4ccc(Cl)cc4)c(-c4ccc(Cl)cc4Cl)nc32)cc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)COC1CCN(C2CCN(C(=O)[C@@H](Cc3cc(C)c(O)c(C)c3)OC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)CC2)CC1.Cl.O.[Li+].[OH-]>>Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCC(OCC(=O)O)CC3)CC2)cc(C)c1O",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.O=C(O)c1cc(Cl)cc(O)c1O.O=S(=O)(O)O>>COC(=O)c1cc(Cl)cc(O)c1O",
        "output": "33"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)NC[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1Cc1ccccc1.COCCCOc1cc(C=O)ccc1OC.ClCCCl.O=C([O-])O.[Na+].[Na+]>>COCCCOc1cc(CN(C[C@H]2CN(C(=O)OC(C)(C)C)C[C@@H]2Cc2ccccc2)C(C)C)ccc1OC",
        "output": "567"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1O[C@H]1CCCNC1.CS(=O)(=O)Cl.Cl.ClCCl>>COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1O[C@H]1CCCN(S(C)(=O)=O)C1",
        "output": "584"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCCCCCCCCCCCCCCC(=O)O.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl>>CCCCCCCCCCCCCCCCCCCC(=O)Cl",
        "output": "56"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)n1ncc(C#N)c1-c1cn2c(n1)-c1ccc(C(=O)O)cc1OCC2.N>>CC(C)n1ncc(C#N)c1-c1cn2c(n1)-c1ccc(C(N)=O)cc1OCC2",
        "output": "358"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCc1nc(CC)n(-c2ccc(OC)cc2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCCc1nc(CC)n(-c2ccc(OC)cc2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)c1nc(NCc2ccc(NC(=O)c3ccc(F)cc3)cc2)c2ccc(C=O)cc2n1.CO.[BH4-].[Na+]>>CN(C)c1nc(NCc2ccc(NC(=O)c3ccc(F)cc3)cc2)c2ccc(CO)cc2n1",
        "output": "356"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ncc(C)cc1[N+](=O)[O-].ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COc1ncc(CBr)cc1[N+](=O)[O-]",
        "output": "625"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)CCCOc1c(OC)ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc12.CO.[Li+].[OH-]>>COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCCCC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc2ccc(C#N)cc2c1.Cc1ccccc1.O.O=C1CCC(=O)N1Br>>N#Cc1ccc2ccc(CBr)cc2c1",
        "output": "29"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1ncc(Br)cc1N.[K+]>>COc1ncc(B2OC(C)(C)C(C)(C)O2)cc1N",
        "output": "943"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc(OC[C@H]2C[C@H](O)CN2)c2c(Nc3ccc(F)c(Cl)c3)ncnc2c1.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)CO.O=C([O-])O.[Na+]>>COc1cc(OC[C@H]2C[C@H](O)CN2C(=O)CO)c2c(Nc3ccc(F)c(Cl)c3)ncnc2c1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCOC(=O)c1cc2cc(OC(F)(F)F)cc([N+](=O)[O-])c2[nH]1.[C].[Pd]>>CCOC(=O)c1cc2cc(OC(F)(F)F)cc(N)c2[nH]1",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNC1.CC(C)(C)c1cc(CO)cc(C(=O)O)c1.CC(C)=O.CCOC(C)=O.O.O=C1CCC(=O)N1Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)c1cc(CN2CCCC2)cc(C(=O)O)c1",
        "output": "765"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.C1CCOC1.COC(=O)[C@@H]1C[C@@H](c2ccccc2)CN1C(=O)OC(C)(C)C.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CC(C)(C)OC(=O)N1C[C@H](c2ccccc2)C[C@H]1CO",
        "output": "430"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CCOC(=O)/C=C/c1ccc(Br)cc1.N[C@@H]1CCN(Cc2ccccc2)C1.O=C([O-])[O-].[Cl-].[Cs+].[Cs+].[NH4+].[Pd+2]>>CCOC(=O)/C=C/c1ccc(N[C@@H]2CCN(Cc3ccccc3)C2)cc1",
        "output": "519"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1nccn1-c1ccc(CO)cc1.O=S(Cl)Cl>>Cc1nccn1-c1ccc(CCl)cc1",
        "output": "81"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)CC1CCN(CC(=O)O)C(=O)c2ccccc21.CCOC(=O)C(C#N)=NOC(N(C)C)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[B-](F)(F)F.NCc1ccc(Nc2nc3ccccc3[nH]2)cc1>>CC(C)(C)OC(=O)CC1CCN(CC(=O)NCc2ccc(Nc3nc4ccccc4[nH]3)cc2)C(=O)c2ccccc21",
        "output": "599"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCC(C)n1cc(C(=O)O)c2cnc(Br)cc21.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NC1CCOCC1.O=C([O-])O.[Na+]>>CCC(C)n1cc(C(=O)NC2CCOCC2)c2cnc(Br)cc21",
        "output": "674"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3cccc(C(=O)NC(C)(C)c4ccccc4)c3)cc12.CCOC(C)=O.CN(C)C=O.[Na+].[OH-]>>CN(c1cc2oc(-c3ccc(F)cc3)c(C(=O)O)c2cc1-c1cccc(C(=O)NC(C)(C)c2ccccc2)c1)S(C)(=O)=O",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCC[C@@H](C)C[C@H](CN)CC(=O)OC(C)(C)C.Cl>>CCCCC[C@@H](C)C[C@H](CN)CC(=O)O",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1ncn2c1CN(C)C(=O)c1c(Cl)cccc1-2.Cl.[BH4-].[Li+]>>CN1Cc2c(CO)ncn2-c2cccc(Cl)c2C1=O",
        "output": "286"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CC#N.CC(C)(C)OC(=O)N1C[C@H](NOCc2ccccc2)CC[C@H]1C(=O)O.CCN(C(C)C)C(C)C.CCOC(C)=O>>CC(C)(C)OC(=O)N1C[C@H](NOCc2ccccc2)CC[C@H]1C(=O)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)NC(C)C.CN(CC1CCNCC1)C1CCCCC1.Cl.O=C(Cl)Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1>>CN(CC1CCN(C(=O)Oc2ccc(Oc3ccc(C(F)(F)F)cn3)cc2)CC1)C1CCCCC1",
        "output": "219"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)N(C)CC(O)CO.Cl.O>>COc1ccc(C[C@H](NC(=O)N(C)CC(O)CO)C(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(-c2cccc(C(=O)CC(=O)Nc3cc(C(F)(F)F)c(C4CC4)cc3NC(=O)OC(C)(C)C)c2)ccn1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(-c2cccc(C3=Nc4cc(C5CC5)c(C(F)(F)F)cc4NC(=O)C3)c2)ccn1",
        "output": "930"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)S.CC(C)=O.CCC(CC)(c1ccc(CCBr)c(C)c1)c1ccc(OC[C@@H]2COC(C)(C)O2)c(C)c1.CCO.O.[K+].[OH-]>>CCC(CC)(c1ccc(CCSC(C)(C)C)c(C)c1)c1ccc(OC[C@@H]2COC(C)(C)O2)c(C)c1",
        "output": "185"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Nc1cccc(NCc2ccccc2)c1.CCOC(=O)CSc1cnc(N)s1.CCOC(=O)CSc1cnc(NC(=O)N(Cc2ccccc2)c2cccc(NC(C)=O)c2)s1.CS(=O)(=O)c1ccc(N(CC2CCCC2)C(=O)Nc2nc(CC(=O)O)cs2)cc1>>CC(=O)Nc1cccc(N(Cc2ccccc2)C(=O)Nc2ncc(SCC(=O)O)s2)c1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCNc1cc(-c2ccc(CN3CCOCC3)cc2)cc(C(=O)O)c1C.CS(C)=O.Cc1cc(C)c(CN)c(=O)[nH]1.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CCNc1cc(-c2ccc(CN3CCOCC3)cc2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Br.CC(=O)O.CCO.Cc1c(C(=O)OCC(Cl)(Cl)Cl)nc(-c2ccc(Cl)cc2Cl)n1-c1ccc(OCc2ccccc2)cc1>>Cc1c(C(=O)OCC(Cl)(Cl)Cl)nc(-c2ccc(Cl)cc2Cl)n1-c1ccc(O)cc1",
        "output": "698"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCC.CN[C@@H]1CCCC[C@H]1N1CCCC1.ClCCl.O=C(O)COc1ccc(Cl)cc1>>CN(C(=O)COc1ccc(Cl)cc1)[C@@H]1CCCC[C@H]1N1CCCC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)O.CN1CCN(c2cccc(N)c2[N+](=O)[O-])CC1.O=C1CCC(=O)N1Cl>>CN1CCN(c2ccc(Cl)c(N)c2[N+](=O)[O-])CC1",
        "output": "121"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)O.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.COC(=O)C1=CCC(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CC1(C)c1ccc(Cl)c(C(F)(F)F)c1.[F-]>>COC(=O)C1=CCC(CO)CC1(C)c1ccc(Cl)c(C(F)(F)F)c1",
        "output": "781"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COC(=O)c1ccc(C)c(NC(=O)c2cc(N3CCCC(CO[Si](C)(C)C(C)(C)C)C3)ccc2C)c1C.[F-]>>COC(=O)c1ccc(C)c(NC(=O)c2cc(N3CCCC(CO)C3)ccc2C)c1C",
        "output": "708"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCN1.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)Cc1cncc(N2CCc3cc(Cl)ccc3C2=O)c1>>O=C(Cc1cncc(N2CCc3cc(Cl)ccc3C2=O)c1)N1CCOCC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)CC(C)C.CCN(CC)CC.Cl.FC(F)(F)c1cccc(N2CCNCC2)c1.O=C([O-])[O-].O=c1[nH]c(-c2ccc(CCCl)cc2)cs1.[I-].[Na+].[Na+].[Na+]>>O=c1[nH]c(-c2ccc(CCN3CCN(c4cccc(C(F)(F)F)c4)CC3)cc2)cs1",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCc1c(O)ccc2c(=O)cc(-c3ccc(C(=O)O)cc3)oc12.CCO.CCOC(C)=O.Cl>>CCCc1c(O)ccc2c(=O)cc(-c3ccc(C(=O)OCC)cc3)oc12",
        "output": "47"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N(Cc1ccc(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)cc1)C(C)C.CCOC(C)=O.O=C(O)C(F)(F)F>>CC(C)N(Cc1ccc(C(=O)N2CCNCC2)cc1)C(C)C",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)N1CCC(=O)CC1.CO.O=C1OC[C@H]2CCCC[C@@H]2N1C1CCNCC1.[BH3-]C#N.[Na+]>>CCOC(=O)N1CCC(N2CCC(N3C(=O)OC[C@H]4CCCC[C@@H]43)CC2)CC1",
        "output": "187"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COc1ccccc1N1CCNCC1.Clc1cc(Cl)c(OCC2CO2)c(Cl)c1Cl>>COc1ccccc1N1CCN(CC(O)COc2c(Cl)cc(Cl)c(Cl)c2Cl)CC1",
        "output": "76"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(=O)Cc1nc2ccc(C(=O)O)cc2[nH]1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CNC.F[P-](F)(F)(F)(F)F>>CCOC(=O)Cc1nc2ccc(C(=O)N(C)C)cc2[nH]1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](C1)C[C@@H](OC(C)=O)[C@H]1[C@@H]3CC[C@H](C(C)CC=C(c4ccccc4)c4ccccc4)[C@@]3(C)[C@@H](O)C[C@@H]12.CCC(C)(C)C(=O)Cl.CCCCCC.CCOCC.c1cc(N2CCCC2)ccn1.c1ccncc1>>CCC(C)(C)C(=O)O[C@H]1C[C@H]2[C@@H]([C@H](OC(C)=O)C[C@@H]3C[C@H](OC(C)=O)CC[C@@]32C)[C@@H]2CC[C@H](C(C)CC=C(c3ccccc3)c3ccccc3)[C@@]12C",
        "output": "126"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)CC(=O)Cl.CCN(CC)CC.ClCCl.O=C(NCC1CC12CCCCN2)c1cc2cnccc2[nH]1.O=C(O)C(F)(F)F>>CC(C)(C)CC(=O)N1CCCCC12CC2CNC(=O)c1cc2cnccc2[nH]1",
        "output": "125"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.CCOCC.COc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(-c3ccc(S(=O)(=O)C(F)(F)F)cc3)ccc2c1.Cl.ClCCl.O=C([O-])O.[Na+]>>O=S(=O)(c1ccc(-c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1)C(F)(F)F",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.N#Cc1cc(Cl)c(F)cc1F.OCc1ccc(Cl)c(Cl)c1.[H-].[Na+]>>N#Cc1cc(Cl)c(OCc2ccc(Cl)c(Cl)c2)cc1F",
        "output": "485"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1nn(C)c2c1CCc1cnc(Nc3ccccc3)nc1-2.CO.Cl.O.O.O.[Li+].[OH-]>>Cn1nc(C(=O)O)c2c1-c1nc(Nc3ccccc3)ncc1CC2",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)CN(C)C(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)NO)n1.Cl.O.O.[Li+].[OH-]>>CN(CC(=O)O)C(=O)c1noc([C@H](CCCC2CCCCC2)CC(=O)NO)n1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1=C(c2ccc(F)c([N+](=O)[O-])c2)CNC1=O.CS(C)=O.Cc1ncc[nH]1.O>>CC1=C(c2ccc(-n3ccnc3C)c([N+](=O)[O-])c2)CNC1=O",
        "output": "701"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[O-].COc1cnc(Cl)nc1.Cc1ccccc1.Cc1nc(C(=O)N2CCC[C@H](C)[C@@H]2CN)c(-c2ccc(F)cc2)s1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COc1cnc(NC[C@H]2[C@@H](C)CCCN2C(=O)c2nc(C)sc2-c2ccc(F)cc2)nc1",
        "output": "544"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1cccc(C)c1-c1cc(CCl)on1.Fc1cccc(-c2nc3cn[nH]cc-3n2)c1F>>Cc1cccc(C)c1-c1cc(Cn2cc3nc(-c4cccc(F)c4F)nc-3cn2)on1",
        "output": "997"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)Cc1ccc(-n2ccc3cc(C(=O)NCCc4ccc(Cl)cc4)ccc32)c(C#N)c1.ClCCl.O=C(O)C(F)(F)F>>N#Cc1cc(CC(=O)O)ccc1-n1ccc2cc(C(=O)NCCc3ccc(Cl)cc3)ccc21",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)c1ccncc1.CS(=O)(=O)c1ccc2c(c1)OC(CO)CO2.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>Cc1ccc(S(=O)(=O)OCC2COc3ccc(S(C)(=O)=O)cc3O2)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Clc1ccnc(Cl)n1.N=C(N)Nc1ccc(-c2cccc(O)c2)cc1.O=C([O-])[O-].[K+].[K+]>>N=C(N)Nc1ccc(-c2cccc(Oc3ccnc(Cl)n3)c2)cc1",
        "output": "668"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C#CC(C)(C)O.Cc1nc2ccccc2[nH]1.Cc1nc2ccccc2n1Cc1c(C(N)=O)nc2n1CCOc1ccc(Br)cc1-2.NC(=O)c1cn2c(n1)-c1ccccc1OCC2>>Cc1nc2ccccc2n1Cc1c(C(N)=O)nc2n1CCOc1ccc(C#CC(C)(C)O)cc1-2",
        "output": "659"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.CC(C)(C)OC(=O)N[C@H](Cc1cc(Br)c(N)c(Br)c1)C(=O)O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F.c1cc(N2CCNCC2)ncn1>>CC(C)(C)OC(=O)N[C@H](Cc1cc(Br)c(N)c(Br)c1)C(=O)N1CCN(c2ccncn2)CC1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.O=[N+]([O-])c1ccc(F)c(C(F)(F)F)c1.OCc1ccccc1.[H-].[Na+]>>O=[N+]([O-])c1ccc(OCc2ccccc2)c(C(F)(F)F)c1",
        "output": "485"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C=CC(=O)Cl.C=CC(=O)O.CCN(CC)CC.Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCN1CCN(C2COC(=O)C2)CC1>>C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCN1CCN(C2COC(=O)C2)CC1",
        "output": "10"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C=CCC1(CCO[Si](C(C)C)(C(C)C)C(C)C)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N(CC2CC2)C1=O.O.O=[Os](=O)(=O)=O.[Na+].[O-][I+3]([O-])([O-])[O-]>>CC(C)[Si](OCCC1(CC=O)C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N(CC2CC2)C1=O)(C(C)C)C(C)C",
        "output": "571"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(CC=O)CC1.CO.C[C@H]1CN(c2ccc(S(C)(=O)=O)cc2)CCN1.[BH4-].[Na+]>>C[C@H]1CN(c2ccc(S(C)(=O)=O)cc2)CCN1CCC1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "484"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)NC1(C(=O)O)CC1.NC1CCc2cc(Br)cc(F)c21>>CC(C)(C)OC(=O)NC1(C(=O)NC2CCc3cc(Br)cc(F)c32)CC1",
        "output": "599"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC/C=C\\CCO.O=C(O)CCl>>CC/C=C\\CCOC(=O)CCl",
        "output": "17"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc2ccccc2c1CCN.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F.[K+].[OH-].c1ccncc1>>COc1ccc2ccccc2c1CCNC(=O)C(F)(F)F",
        "output": "316"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=CCCC(C)=CCCC(C)=CCCC#C[Si](C)(C)C.CC[O-].COC(C)(C)C.O.[Na+]>>C#CCCC=C(C)CCC=C(C)CCC=C(C)C",
        "output": "337"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.COc1cnc(Oc2cc(C)c(C(=O)CBr)c(C)c2)nc1.NC(N)=S>>COc1cnc(Oc2cc(C)c(-c3csc(N)n3)c(C)c2)nc1",
        "output": "716"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CC(=O)[O-].CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O.O.O=C1CSC(=O)N1.[Na+]>>CC(C)(C)c1cc(C=C2SC(=O)NC2=O)cc(C(C)(C)C)c1O",
        "output": "761"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1cnc2ccc(Cl)nc2c1NC1CCN(C)CC1.CC1(C)OB(c2cc(F)c(O)c(Cl)c2)OC1(C)C>>CC(=O)c1cnc2ccc(-c3cc(F)c(O)c(Cl)c3)nc2c1NC1CCN(C)CC1",
        "output": "955"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CC(C)=O.N#Cc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>N#Cc1ccc(OCc2ccccc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CC[Si](Cl)(CC)CC.CN(C)c1ccncc1.O=C([O-])O.O=S(=O)(C1CC1)N1CC(O)C1.[Na+]>>CC[Si](CC)(CC)OC1CN(S(=O)(=O)C2CC2)C1",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.Cc1cc(C(=O)Nc2c(F)ccc(O)c2C)cc(-c2cccc(F)c2)c1>>Cc1cc(CNc2c(F)ccc(O)c2C)cc(-c2cccc(F)c2)c1",
        "output": "215"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCOc1cnc(CO)cc1O.ClC(Cl)Cl.O=S(Cl)Cl>>CCCOc1cnc(CCl)cc1O",
        "output": "594"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1c(-c2ccccc2)nn2cc(-c3ccccc3)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CC(C)(O)C4)cc3)nc12.ClCCl.O=C(O)C(F)(F)F>>Cc1c(-c2ccccc2)nn2cc(-c3ccccc3)c(-c3ccc(C4(N)CC(C)(O)C4)cc3)nc12",
        "output": "793"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCCCON1C(C)(C)CC(CCCCNc2nc(Cl)nc(NCCCCC3CC(C)(C)N(OCCCCCCCC)C(C)(C)C3)n2)CC1(C)C.NCCC(=O)O>>CCCCCCCCON1C(C)(C)CC(CCCCNc2nc(NCCCCC3CC(C)(C)N(OCCCCCCCC)C(C)(C)C3)nc(NCCC(=O)O)n2)CC1(C)C",
        "output": "578"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.N=C(N)Nc1nc(-c2ccccc2[N+](=O)[O-])cs1.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[S-2]>>N=C(N)Nc1nc(-c2ccccc2N)cs1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1=COCCC1.CC(CO)(CCCBr)c1ccccc1.Cc1ccc(S(=O)(=O)O)cc1.ClCCl.O>>CC(CCCBr)(COC1CCCCO1)c1ccccc1",
        "output": "141"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cc1ccc(Oc2cccc(CN)c2)cc1.Nc1ncccc1C(=O)O.O.On1nnc2ccccc21.c1ccncc1>>Cc1ccc(Oc2cccc(CNC(=O)c3cccnc3N)c2)cc1",
        "output": "790"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOCC.COC(=O)COc1ccc(N(C)Cc2cnc(-c3ccc(C(F)(F)F)cc3)nc2C2CC2)cc1C.[Li+].[OH-]>>Cc1cc(N(C)Cc2cnc(-c3ccc(C(F)(F)F)cc3)nc2C2CC2)ccc1OCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(C)(C)OC(=O)NC1CCCN(c2ccc(C(=O)c3ccccc3)cc2N)C1.Nc1ncc(Br)nc1C(=O)O>>CC(C)(C)OC(=O)NC1CCCN(c2ccc(C(=O)c3ccccc3)cc2NC(=O)c2nc(Br)cnc2N)C1",
        "output": "889"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.NC(c1cccc(F)c1)c1cccc(C(F)(F)F)c1.O=C(O)CNC(=O)c1ccc(F)cc1>>O=C(CNC(=O)c1ccc(F)cc1)NC(c1cccc(F)c1)c1cccc(C(F)(F)F)c1",
        "output": "769"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCOC(C)=O.CO.C[O-].ClCCCBr.SCc1ccco1.[Na+]>>ClCCCSCc1ccco1",
        "output": "185"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COc1cccc2[nH]c(C(=O)NC3CCN(CCN4CCCCCC4)CC3)cc12.ClCCl>>O=C(NC1CCN(CCN2CCCCCC2)CC1)c1cc2c(O)cccc2[nH]1",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O.COc1ccc(-c2cccc(Oc3ccc(C=C4SC(=O)NC4=O)cc3)c2)cc1.O=C[O-].[NH4+].[Pd]>>COc1ccc(-c2cccc(Oc3ccc(CC4SC(=O)NC4=O)cc3)c2)cc1",
        "output": "762"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc2c(c1)CC(C)(C)C(c1ccc(F)c(NC(=O)c3ccccc3)c1)N2.O.[Na+].[OH-]>>CC1(C)Cc2cc(C(=O)O)ccc2NC1c1ccc(F)c(NC(=O)c2ccccc2)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)c1cccnc1)C(C)(C)S(C)(=O)=O.O=C1CCC(=O)O1>>CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](OC(=O)CCC(=O)O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)c1cccnc1)C(C)(C)S(C)(=O)=O",
        "output": "139"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)C(=O)c1ccc(OCCOC2CCCCCCC2)s1.CO.[K+].[OH-]>>O=C(O)C(=O)c1ccc(OCCOC2CCCCCCC2)s1",
        "output": "472"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Brc1cncc(OC[C@@H]2CCN2)c1.C=O.CC(=O)O.[BH3-]C#N.[Na+]>>CN1CC[C@H]1COc1cncc(Br)c1",
        "output": "217"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCN=C=NCCCN(C)C.CCOc1ccc(C(=O)CCC(=O)O)cc1Cl.Nc1nc(-c2ccccc2)c(Cc2ccccc2)s1.On1nnc2ccccc21>>CCOc1ccc(C(=O)CCC(=O)Nc2nc(-c3ccccc3)c(Cc3ccccc3)s2)cc1Cl",
        "output": "681"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)OC(C)=O.CC(N)c1ccc(Nc2ncc(C(F)(F)F)c(CCc3ccccc3C3(C(N)=O)CC3)n2)cc1.ClCCl.c1ccncc1>>CC(=O)NC(C)c1ccc(Nc2ncc(C(F)(F)F)c(CCc3ccccc3C3(C(N)=O)CC3)n2)cc1",
        "output": "515"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCN1.O=C(O)c1cc(-c2cc(F)cc(OC(F)(F)F)c2)n(-c2cccnc2)n1.O=C1CN(C(=O)c2cc(-c3cc(F)cc(Cl)c3)n(-c3ccccn3)n2)CN1>>O=C(c1cc(-c2cc(F)cc(OC(F)(F)F)c2)n(-c2cccnc2)n1)N1CCOCC1",
        "output": "663"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)c1ccc(C(=O)OC(C)(C)C)c(Cl)c1.ClCCl.O=C(O)C(F)(F)F>>CC(C)c1ccc(C(=O)O)c(Cl)c1",
        "output": "752"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#CCNC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(C)=O.COC(=O)c1ccc(Br)s1.[Pd]>>COC(=O)c1ccc(C#CCNC(=O)OC(C)(C)C)s1",
        "output": "766"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)C(=O)CC(=O)c1ccc(CCc2ccccc2)s1.CO.Cl.[Na+].[OH-]>>O=C(O)C(=O)CC(=O)c1ccc(CCc2ccccc2)s1",
        "output": "472"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(C)=O.CNCC(C)(CC=C(C)C)c1ccccc1.O=S(=O)(Cl)c1ccccc1>>CC(C)=CCC(C)(CN(C)S(=O)(=O)c1ccccc1)c1ccccc1",
        "output": "99"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCN(CC)CC.CS(C)=O.Nc1cnc(Cl)nc1Cl>>CC(C)(C)OC(=O)N1CCN(c2nc(Cl)ncc2N)CC1",
        "output": "296"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1cnc(C#Cc2c(F)cccc2Cl)n1-c1ccc(F)cc1.CO.Cc1nn(C)cc1CN(C)C(=O)c1cnc(S)n1-c1ccc(F)cc1.O.[Li+].[OH-]>>O=C(O)c1cnc(C#Cc2c(F)cccc2Cl)n1-c1ccc(F)cc1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)c1ccc(B(O)O)s1.FC(F)(F)Oc1ccc(Br)cc1>>CC(=O)c1ccc(-c2ccc(OC(F)(F)F)cc2)s1",
        "output": "903"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(N)cc1.N#CC1(c2ccc(C(=O)O)cc2)CCCC1.O=S(Cl)Cl>>COc1ccc(NC(=O)c2ccc(C3(C#N)CCCC3)cc2)cc1",
        "output": "817"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cn(C(C[C@H]2CCCCO2)C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)cc1-c1cc(Cl)ccc1OC(F)F.O=C(O)C(F)(F)F>>COc1cn(C(C[C@H]2CCCCO2)C(=O)Nc2ccc(C(=O)O)cc2)c(=O)cc1-c1cc(Cl)ccc1OC(F)F",
        "output": "752"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(N2CCCC2)ncc1N.O=C(O)c1cc2cc(F)ccc2n1Cc1cccc(F)c1>>COc1cc(N2CCCC2)ncc1NC(=O)c1cc2cc(F)ccc2n1Cc1cccc(F)c1",
        "output": "776"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1ccc(OCc2c(-c3cccc(C)c3)noc2C)nc1.COC(=O)c1ccc(OCc2c(-c3ccccc3F)noc2C)nc1.NC1CCOCC1>>Cc1cccc(-c2noc(C)c2COc2ccc(C(=O)NC3CCOCC3)cn2)c1",
        "output": "862"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CS(C)=O.O.O=C(O)c1cnc(Cl)c(Br)c1.OC1CCC1.[K+].[OH-]>>O=C(O)c1cnc(OC2CCC2)c(Br)c1",
        "output": "433"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.ClCCl.F[P-](F)(F)(F)(F)F.Fc1ccc(C(=C2CCNCC2)c2ccc(F)cc2)cc1.O=C(O)CN1CCCC(c2ccccc2)(c2ccccc2)C1=O>>O=C(CN1CCCC(c2ccccc2)(c2ccccc2)C1=O)N1CCC(=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.BrB(Br)Br.COc1ccc2c(c1)c(=O)c(-c1ncc(Cc3ccccc3)o1)cn2Cc1ccc(Cl)cc1.ClCCl>>O=c1c(-c2ncc(Cc3ccccc3)o2)cn(Cc2ccc(Cl)cc2)c2ccc(O)cc12",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C(=O)OC(C)(C)C)C1CN(c2nc3ncc([N+](=O)[O-])cc3n3cnnc23)C1.CO.[H][H].[Pd]>>CN(C(=O)OC(C)(C)C)C1CN(c2nc3ncc(N)cc3n3cnnc23)C1",
        "output": "269"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)CNC(=O)c1cc2cc(Cl)ncc2[nH]1.[Na+].[OH-]>>O=C(O)CNC(=O)c1cc2cc(Cl)ncc2[nH]1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCl.Nc1ccc(O)cc1.O=C=Nc1ccc(Cl)c(C(F)(F)F)c1>>O=C(Nc1ccc(O)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1",
        "output": "473"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCO.C[C@H](OP(=O)(O)C(Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1.O.[Li+].[OH-]>>C[C@H](OP(=O)(O)C(Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.COc1cccc(N)c1.ClCCl.O=C(Cl)C=Cc1ccccc1.c1ccncc1>>COc1cccc(NC(=O)C=Cc2ccccc2)c1",
        "output": "10"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.NN.O.O=C1c2ccccc2C(=O)N1Cc1cc(-c2ccc(C(F)(F)F)cc2)nc(-c2cccnc2)n1>>NCc1cc(-c2ccc(C(F)(F)F)cc2)nc(-c2cccnc2)n1",
        "output": "242"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1c(O)ccc(C(C)=O)c1O.N#Cc1ccnc(Sc2cccc(CO)c2)c1>>CCc1c(OCc2cccc(Sc3cc(C#N)ccn3)c2)ccc(C(C)=O)c1O",
        "output": "347"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)Cl.C[C@@H](O[C@H]1CCN(C(=O)[C@@H]2CC[C@@H](N)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl>>COC(=O)N[C@@H]1CC[C@@H](C(=O)N2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1",
        "output": "94"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12.CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCCC[N+](CCCC)(CCCC)CCCC.CO.[Br-].[Br-].[Br-]>>O=C(CBr)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12",
        "output": "360"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCCCBr.CCCC[N+](CCCC)(CCCC)CCCC.O=S(=O)([O-])O.Oc1ccc(Cl)c(Cl)c1.[Na+].[OH-]>>Clc1ccc(OCCCBr)cc1Cl",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CSc1ccc(-c2cc(COS(C)(=O)=O)c(=O)n(CC3CC3)n2)cc1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=S([O-])O.[Na+]>>CS(=O)c1ccc(-c2cc(COS(C)(=O)=O)c(=O)n(CC3CC3)n2)cc1",
        "output": "500"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCNCC1.CCO.COc1cc2c(=O)[nH]cnc2cc1OCCCCl>>COc1cc2c(=O)[nH]cnc2cc1OCCCN1CCCCC1",
        "output": "138"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCn1ncc2c(NCc3cccc(OC)c3)c3ccccc3nc21.Cl.[Na+].[OH-].c1ccncc1>>CCn1ncc2c(NCc3cccc(O)c3)c3ccccc3nc21",
        "output": "732"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(O)cc1CC2C(C)(C)C.CN(C)C=O.O=C([O-])[O-].O=C1c2ccccc2C(=O)N1CCBr.[K+].[K+]>>CCOC(=O)c1cn2c(cc1=O)-c1cc(OC)c(OCCN3C(=O)c4ccccc4C3=O)cc1CC2C(C)(C)C",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)c1ccc(C(=O)NCCc2ccc(Cl)c(Cl)c2)c(Cl)c1.Cl.[Na+].[OH-]>>CC(C)(C)c1ccc(CNCCc2ccc(Cl)c(Cl)c2)c(Cl)c1",
        "output": "215"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.ClCCCBr.O=C([O-])[O-].O=c1[nH]c(Cl)c(-c2ccccc2)c(=O)n1Cc1ccccc1.[K+].[K+]>>O=c1c(-c2ccccc2)c(Cl)n(CCCCl)c(=O)n1Cc1ccccc1",
        "output": "327"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCCCC.CCN.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.CS(=O)(=O)c1ccc(Oc2cc(OC3CCOCC3)c3[nH]c(C4=NCC(CC(=O)O)S4)cc3c2)cn1.Cl.O.O.On1nnc2ccccc21>>CCNC(=O)CC1CN=C(c2cc3cc(Oc4ccc(S(C)(=O)=O)nc4)cc(OC4CCOCC4)c3[nH]2)S1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CN(C)c1ccncc1.CN(CCO[Si](C)(C)C(C)(C)C)CC[C@H](CSc1ccccc1)Nc1ccc(S(N)(=O)=O)cc1S(=O)(=O)C(F)(F)F.CO.ClCCCl.ClCCl.O=C(O)c1ccc(N2CCC([C@@H](O)c3ccccc3-c3ccc(Cl)cc3)CC2)cc1.O=C([O-])O.[Na+]>>CN(CCO[Si](C)(C)C(C)(C)C)CC[C@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCC([C@@H](O)c4ccccc4-c4ccc(Cl)cc4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F",
        "output": "579"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1cnc(C(=O)N(C)C)c(=O)n1-c1cccc(C(F)(F)F)c1.O=C1CCC(=O)N1Br>>Cc1c(Br)nc(C(=O)N(C)C)c(=O)n1-c1cccc(C(F)(F)F)c1",
        "output": "665"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCCn1nc(Cc2ccc(C)cc2)cc1COC(=O)c1ccc(SC(C)(C)C(=O)OC(C)(C)C)cc1.CO>>CCCn1nc(Cc2ccc(C)cc2)cc1COC(=O)c1ccc(SC(C)(C)C(=O)O)cc1",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN[C@@H](C)COc1cccc2ncnc(Nc3ccc(O)c(Cl)c3)c12.COCC(=O)O>>COCC(=O)N(C)[C@@H](C)COc1cccc2ncnc(Nc3ccc(O)c(Cl)c3)c12",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)NCCNCCCc1c[nH]c2ccc(-n3cnnc3)cc12.CO.O=Cc1ccccc1.[BH3-]C#N.[Na+]>>CC(C)(C)OC(=O)NCCN(CCCc1c[nH]c2ccc(-n3cnnc3)cc12)Cc1ccccc1",
        "output": "567"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1onc(-c2ccccc2)c1-c1cn2cc(C(=O)O)ccc2n1.Cc1onc(-c2ccccc2)c1-c1cn2cc(NC(=O)OC(C)(C)C)ccc2n1>>Cc1onc(-c2ccccc2)c1-c1cn2cc(N)ccc2n1",
        "output": "877"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNCC1.CCCCO.ClCCCOc1ccc(I)cc1.O.O=C([O-])[O-].[I-].[K+].[Na+].[Na+]>>Ic1ccc(OCCCN2CCCCC2)cc1",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCN)CC1.ClCCl.O=S(=O)(Cl)c1ccccc1>>COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCNS(=O)(=O)c2ccccc2)CC1",
        "output": "43"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(Cc1ccc(Oc2ccc([N+](=O)[O-])c(O)c2)cc1)Nc1ccc(Br)cn1.OB(O)c1ccc(Cl)c(Cl)c1>>O=C(Cc1ccc(Oc2ccc([N+](=O)[O-])c(O)c2)cc1)Nc1ccc(-c2ccc(Cl)c(Cl)c2)cn1",
        "output": "833"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)N.CN(C)C=O.COc1cc(OC)c2c(=O)[nH]c(-c3ccc(OCCBr)c(-c4ccccc4)n3)nc2c1>>COc1cc(OC)c2c(=O)[nH]c(-c3ccc(OCCNC(C)C)c(-c4ccccc4)n3)nc2c1",
        "output": "147"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cc2ccc(C(F)C(N)=O)cc2s1.CO.Cl.[Li+].[OH-]>>NC(=O)C(F)c1ccc2cc(C(=O)O)sc2c1",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(=O)Cl.CNCc1cc(CCCO)ccc1[C@@H]1CC[C@@H](N(C)C(=O)c2ccc(Cl)cc2)CC1>>CNCc1cc(CCCOC(=O)C(C)(C)C)ccc1[C@@H]1CC[C@@H](N(C)C(=O)c2ccc(Cl)cc2)CC1",
        "output": "126"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCC.CCOC(C)=O.Fc1cccc(-c2cc(N3CCNCC3)ncn2)c1.O=C(Nc1cccnc1)OCC(Cl)(Cl)Cl>>O=C(Nc1cccnc1)N1CCN(c2cc(-c3cccc(F)c3)ncn2)CC1",
        "output": "980"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.C1COCCOCCOCCOCCOCCO1.C[C@H]1Cn2ncc(N3CC(NCCO[Si](C)(C)C(C)(C)C)CC3=O)c2CN1C(=O)OC(C)(C)C.[F-].[K+]>>C[C@H]1Cn2ncc(N3CC(NCCO)CC3=O)c2CN1C(=O)OC(C)(C)C",
        "output": "708"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CCOCC.ClCCl.Nc1cc([N+](=O)[O-])ccc1O.O.[Cl-].[NH4+]>>CC(C)(C)[Si](C)(C)Oc1ccc([N+](=O)[O-])cc1N",
        "output": "746"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Br.CC(=O)O.CCOC(=O)N1C2CCC1CC(=C1c3ccccc3Oc3cc(C(=O)N(CC)CC)ccc31)C2>>CCN(CC)C(=O)c1ccc2c(c1)Oc1ccccc1C2=C1CC2CCC(C1)N2",
        "output": "283"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CCN(C)C(=O)c1cc(-c2ccc(CN)cn2)n(-c2ccc(C)nc2)n1>>CCN(C)C(=O)c1cc(-c2ccc(CNC(C)=O)cn2)n(-c2ccc(C)nc2)n1",
        "output": "45"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CO.Cl.ClCCl.NO.O=C1CCN(c2ccc(N3C[C@H](COc4ccon4)OC3=O)cc2F)CC1.[Na+]>>O=C1O[C@@H](COc2ccon2)CN1c1ccc(N2CCC(=NO)CC2)c(F)c1",
        "output": "86"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CO1.CCC(=O)N(c1ccccc1)C1CCNCC1.CO.Cc1ccccc1>>CCC(=O)N(c1ccccc1)C1CCN(CCO)CC1",
        "output": "76"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C#C[Si](C)(C)C.C1CCOC1.CCN(CC)CC.Cl[Pd]Cl.Fc1cccc(COc2ccc(I)cc2)c1.[Cl-].[NH4+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C[Si](C)(C)C#Cc1ccc(OCc2cccc(F)c2)cc1",
        "output": "826"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)c1ccc(OC[C@@H]2C[C@H](F)CN2C(=O)Cc2ccc3nc(Nc4ccccc4C)oc3c2F)cc1.[Na+].[OH-]>>Cc1ccccc1Nc1nc2ccc(CC(=O)N3C[C@@H](F)C[C@H]3COc3ccc(C(=O)O)cc3)c(F)c2o1",
        "output": "222"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCC(O)CN(Cc1ccc(S(C)(=O)=O)cc1)C(=O)c1ccc(Br)cc1C(=O)c1ccccc1.CCN(CC)CC.CS(C)=O.Cl.O>>CCCCC(=O)CN(Cc1ccc(S(C)(=O)=O)cc1)C(=O)c1ccc(Br)cc1C(=O)c1ccccc1",
        "output": "87"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.O=Cc1cc2cccc(Cl)c2nc1-c1ccccc1OC(F)(F)F.[BH4-].[Na+]>>OCc1cc2cccc(Cl)c2nc1-c1ccccc1OC(F)(F)F",
        "output": "476"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C(NC(=O)OCc1ccccc1)C(=O)Nc1ccncc1C(=O)O.ClCCCl.ClCCl.NCc1ccccc1>>CC(C)C(NC(=O)OCc1ccccc1)C(=O)Nc1ccncc1C(=O)NCc1ccccc1",
        "output": "790"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.Clc1cnc(-c2ccccc2)c(-c2ccccc2)n1.OCCCCOC1CCCCO1.[H-].[Na+]>>c1ccc(-c2ncc(OCCCCOC3CCCCO3)nc2-c2ccccc2)cc1",
        "output": "209"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CNCCN1.CN(C)C=O.COc1c(Br)cc(C(=O)N2CCOc3c2cnc2ccccc32)cc1Br.Cl.O.[Br-].[Li+]>>O=C(c1cc(Br)c(O)c(Br)c1)N1CCOc2c1cnc1ccccc21",
        "output": "786"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCn1nc(C(=O)O)c(=O)c2c([N+](=O)[O-])c3c(cc21)OCO3.Cl.[Pd]>>CCn1nc(C(=O)O)c(=O)c2c(N)c3c(cc21)OCO3",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)C(C)(C)S(=O)(=O)c1ccc2c(-c3ccc(Cl)cc3)noc2c1.CO.Cl.[Na+].[OH-]>>CC(C)(C(=O)O)S(=O)(=O)c1ccc2c(-c3ccc(Cl)cc3)noc2c1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)C(CC)(CC)NC(=O)c1ccc(C2CC2)c(OCC2CCOCC2)n1.[Na+].[OH-]>>CCC(CC)(NC(=O)c1ccc(C2CC2)c(OCC2CCOCC2)n1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.Nc1ccc(N2CCC(=O)CC2)cc1.O=C1NC(=O)C(Cc2ccc(S(=O)(=O)Cl)cc2)S1>>O=C1CCN(c2ccc(NS(=O)(=O)c3ccc(CC4SC(=O)NC4=O)cc3)cc2)CC1",
        "output": "68"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.COC(=O)c1cccn1NC(=O)[C@H](C)NC(=O)OC(C)(C)C.C[Al](C)C.Cc1ccccc1.Cl.NC1CCCOC1.O.O=C([O-])C(O)C(O)C(=O)[O-].[Na+].[Na+]>>C[C@H](NC(=O)OC(C)(C)C)C(=O)Nn1cccc1C(=O)NC1CCCOC1",
        "output": "487"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.Cl.ClCCCl.ClCCl.Cn1cc(C(=O)O)c(NC(=O)OC(C)(C)C)n1.FC(F)(F)c1cc(Cl)ccc1C1CCCNC1.On1nnc2cccnc21>>Cn1cc(C(=O)N2CCCC(c3ccc(Cl)cc3C(F)(F)F)C2)c(NC(=O)OC(C)(C)C)n1",
        "output": "733"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)c1ccc(-c2c(F)cccc2Cl)cc1NC(=O)c1ccccc1.O=C(O)C(F)(F)F>>O=C(Nc1cc(-c2c(F)cccc2Cl)ccc1C(=O)O)c1ccccc1",
        "output": "752"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CNCCN1.O.O=S(=O)(c1ccc(F)cc1)N1CCCC1>>O=S(=O)(c1ccc(N2CCNCC2)cc1)N1CCCC1",
        "output": "26"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrB(Br)Br.COc1ccccc1-c1nc(C)n(C2CC2)c(=O)c1CCc1ccccc1.ClCCl>>Cc1nc(-c2ccccc2O)c(CCc2ccccc2)c(=O)n1C1CC1",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCO.Cl.N#Cc1ccc(C2(F)CCOCC2)cc1.NO.O>>NC(=NO)c1ccc(C2(F)CCOCC2)cc1",
        "output": "400"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1cnc2ccc(Br)cc2c1Nc1ccc(CCN(C)C)cc1.CC1(C)OB(c2cc(Cl)c(O)c(Cl)c2)OC1(C)C>>CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)cc2c1Nc1ccc(CCN(C)C)cc1",
        "output": "933"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc(-c2ncco2)cc1>>Oc1ccc(-c2ncco2)cc1",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1sc2[nH]c(=O)c(=O)[nH]c2c1C.[Na+].[OH-]>>Cc1c(C(=O)O)sc2[nH]c(=O)c(=O)[nH]c12",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)C[AlH]CC(C)C.CCCCCCCCCCCCCCCCCCOC1CC(C(=O)Nc2ccc(C(=O)OC)c(OC)c2)CC(OCCCCCCCCCCCCCCCCCC)C1OCCCCCCCCCCCCCCCCCC.Cc1ccccc1.Cl>>CCCCCCCCCCCCCCCCCCOC1CC(C(=O)Nc2ccc(CO)c(OC)c2)CC(OCCCCCCCCCCCCCCCCCC)C1OCCCCCCCCCCCCCCCCCC",
        "output": "444"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OCCn1ccc2c([N+](=O)[O-])cccc2c1=O.CO.[Pd]>>CC(=O)OCCn1ccc2c(N)cccc2c1=O",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)(C)OC(=O)N1CCC(Oc2cccc(Br)c2)C1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOC(C)=O.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)(C)OC(=O)N1CCC(Oc2cccc(B3OC(C)(C)C(C)(C)O3)c2)C1",
        "output": "942"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1cc(-c2ccc(C(F)(F)F)cc2)nn1CC(F)(F)F.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1cc(-c2ccc(C(F)(F)F)cc2)nn1CC(F)(F)F",
        "output": "391"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.[Cl-].[NH3+]CCCCl.[Na+].[OH-]>>CC(C)(C)OC(=O)NCCCCl",
        "output": "631"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(C)=O.CO.N[C@H](CCCCNC(=O)OCc1ccccc1)C(=O)O.O=S(Cl)Cl>>CCOC(=O)[C@H](N)CCCCNC(=O)OCc1ccccc1",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.Cl[Sn]Cl.O.O=C(N1CCC[C@H](Oc2cc(Cl)ccc2[N+](=O)[O-])C1)C(F)(F)F.O=C([O-])[O-].[K+].[K+]>>Nc1ccc(Cl)cc1O[C@H]1CCCN(C(=O)C(F)(F)F)C1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cc(C)n(-c2cccc(Br)c2)n1.OB(O)c1ccccc1OC(F)(F)F>>CCOC(=O)c1cc(C)n(-c2cccc(-c3ccccc3OC(F)(F)F)c2)n1",
        "output": "837"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(N)ccc1F.Cc1c(Cl)ncc(C(=O)N2CCC(c3ccc(F)cc3)CC2)c1Cl>>COc1cc(Nc2c(C(=O)N3CCC(c4ccc(F)cc4)CC3)cnc(Cl)c2C)ccc1F",
        "output": "957"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)c1nc(N2CCN(CCCCN)CC2)cc(C(F)(F)F)n1.CO.ClC(Cl)Cl.N#Cc1cccc(N2CCNCC2)c1.O=C(n1ccnc1)n1ccnc1>>CC(C)(C)c1nc(N2CCN(CCCCNC(=O)N3CCN(c4cccc(C#N)c4)CC3)CC2)cc(C(F)(F)F)n1",
        "output": "734"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)Cc1ccc(-c2noc(C)c2C(=O)OC(C)(C)C)c(Cl)c1.O=C(O)C(F)(F)F>>COC(=O)Cc1ccc(-c2noc(C)c2C(=O)O)c(Cl)c1",
        "output": "569"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "NCCN1CCOCC1.O=C(O)C(F)(F)F.O=C1CCN(c2nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc(N3CC4CCC(C3)O4)n2)CC1>>O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCC(NCCN4CCOCC4)CC3)nc(N3CC4CCC(C3)O4)n2)cc1",
        "output": "236"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCNC1.CCN(CC)CC.CN(C)C=O.ClCc1nc(Cl)cc(Cl)n1.O>>ClCc1nc(Cl)cc(N2CCCC2)n1",
        "output": "162"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COCOc1c(CON=C(C)c2cc(C)cc(C)n2)cccc1OC.Cl.[Na+].[OH-]>>COc1cccc(CON=C(C)c2cc(C)cc(C)n2)c1O",
        "output": "755"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.Fc1ccc(I)cc1.N#N.N[C@@H]1CCCC[C@H]1N.Nc1ccc2[nH]ncc2c1.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>Nc1ccc2c(cnn2-c2ccc(F)cc2)c1",
        "output": "901"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.COC(=O)CC1(N)CSC1.O=C(O)c1ccc(C2(O)CCC2)c(OCC2CC2)n1>>COC(=O)CC1(NC(=O)c2ccc(C3(O)CCC3)c(OCC3CC3)n2)CSC1",
        "output": "137"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CS(=O)(=O)c1ccc(CO)c(-c2ccccc2)c1.ClCCl>>CS(=O)(=O)c1ccc(C=O)c(-c2ccccc2)c1",
        "output": "179"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)CC1.FC(F)(F)c1cccc(Cl)n1.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCC(Oc2cccc(C(F)(F)F)n2)CC1",
        "output": "433"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)C(Cc1cccc(B2OC(C)(C)C(C)(C)O2)c1)c1c(SC(C)(C)C)c2cc(O)ccc2n1C.Fc1cnc(Cl)nc1>>CCOC(=O)C(Cc1cccc(-c2ncc(F)cn2)c1)c1c(SC(C)(C)C)c2cc(O)ccc2n1C",
        "output": "974"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCC1CC1.CN(C)C=O.COc1cccc(-c2c(NC(=O)Nc3c(C(C)C)cccc3C(C)C)c(=O)[nH]c3ncccc23)c1.O.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>COc1cccc(-c2c(NC(=O)Nc3c(C(C)C)cccc3C(C)C)c(=O)n(CC3CC3)c3ncccc23)c1",
        "output": "327"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCOC(=O)c1cnc(-c2ccccc2)nc1Oc1ccccc1Cl.Cl.O.[Na+].[OH-]>>O=C(O)c1cnc(-c2ccccc2)nc1Oc1ccccc1Cl",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.CC(C)=O.COC(=O)c1cccc(C2CC(O)c3ccncc3O2)c1.O=S(=O)(O)O.O=[Cr](=O)=O>>COC(=O)c1cccc(C2CC(=O)c3ccncc3O2)c1",
        "output": "32"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCC(O)CCCC(CCCCCCC(=O)O)C(O)CCOC.CCCCCC(O)CCCC(O)CCCCCCC(=O)O.ClC(Cl)Cl>>CCCCCC(O)CCCC(CCCCCCC(=O)O)C(O)CCO",
        "output": "423"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CCN=C=NCCCN(C)C.CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)O)cc4)cc3)nc21.CNCCNC.On1nnc2ccccc21>>CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)N(C)CCNC)cc4)cc3)nc21",
        "output": "44"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@H](c2ccccc2)[C@H](N)C1.COCCCCN1C(=O)C(C)(C)Oc2cc(C(F)(F)F)c(C(=O)O)cc21>>COCCCCN1C(=O)C(C)(C)Oc2cc(C(F)(F)F)c(C(=O)N[C@@H]3CN(C(=O)OC(C)(C)C)CC[C@@H]3c3ccccc3)cc21",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Nc1nn2cccnc2c1Br.O=C(O)Cc1ccc(F)cc1>>O=C(Cc1ccc(F)cc1)Nc1nn2cccnc2c1Br",
        "output": "795"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(C(=O)c2cc(Cl)ccc2N)c1.CCOC(C)=O.CO.[BH4-].[Na+]>>CC(C)(C)OC(=O)Nc1cccc(C(O)c2cc(Cl)ccc2N)c1",
        "output": "157"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=CCCl.CCCCCC.CCOCC.CO.Cc1cc(O)cc(O)c1C(=O)CC(C)C.[H-].[Na+]>>CC(C)=CCOc1cc(C)c(C(=O)CC(C)C)c(O)c1",
        "output": "119"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCSc1ccc(N)cc1C.O=[N+]([O-])c1cc(Cl)ccc1Sc1ccccc1>>Nc1cc(Cl)ccc1Sc1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Nc1cccnc1C(=O)O>>CCOC(=O)c1ncccc1N",
        "output": "331"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)[C@@H](C(=O)O)N1CCN(Cc2ccccc2)C1=O.CCN(C(C)C)C(C)C.CCOP(=O)(OCC)On1nnc2ccccc2c1=O.COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(-c2ccc(C)cn2)cc1)C[C@H](O)[C@@H](N)Cc1ccccc1)C(C)(C)C>>COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(-c2ccc(C)cn2)cc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N1CCN(Cc2ccccc2)C1=O)C(C)(C)C)C(C)(C)C",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CNC.Nc1[nH]nc(CCCBr)c1-c1nc2ccccc2s1.Nc1[nH]nc(CCCO)c1-c1nc2ccccc2s1>>CN(C)CCCc1n[nH]c(N)c1-c1nc2ccccc2s1",
        "output": "371"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.COC(=O)[C@H]1C[C@@H]1C(=O)c1cc(Cl)c2c(c1)OCO2.Cl.[Na+].[OH-]>>O=C(O)[C@H]1C[C@@H]1C(=O)c1cc(Cl)c2c(c1)OCO2",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN1CCN(C(=O)c2cc([N+](=O)[O-])ccc2C(F)(F)F)CC1.CO.ClCCl.O=C[O-].[NH4+].[Pd]>>CCN1CCN(C(=O)c2cc(N)ccc2C(F)(F)F)CC1",
        "output": "489"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOCCN(CCCC(=O)OC(C)(C)C)C(=O)OCc1ccccc1.CO.[Pd]>>CCOCCNCCCC(=O)OC(C)(C)C",
        "output": "428"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(=O)O)n3)cn2)CC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Cl.O=C([O-])[O-].On1nnc2ccccc21.[NH4+].[NH4+]>>CC(C)(C)OC(=O)N1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cn2)CC1",
        "output": "313"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(Cn2nc(Nc3cc(Cl)c(F)c(Cl)c3)nc2N2CCOCC2)cc1.O=C(O)C(F)(F)F>>Fc1c(Cl)cc(Nc2n[nH]c(N3CCOCC3)n2)cc1Cl",
        "output": "978"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "NCC1(c2ccc(C(F)(F)F)nc2)CCC(F)(F)CC1.O=C(O)c1ccccc1Cl>>O=C(NCC1(c2ccc(C(F)(F)F)nc2)CCC(F)(F)CC1)c1ccccc1Cl",
        "output": "334"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(C)=O.Cc1c[nH]cn1.O.O=C([O-])[O-].O=[N+]([O-])c1cccc(F)c1.[K+].[K+]>>Cc1cn(-c2cccc([N+](=O)[O-])c2)cn1",
        "output": "721"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCc1nc2ccc(C(O)(c3cnnn3C)C3CN(C(=O)OC(C)(C)C)C3)cc2c(Cl)c1OCC1CC1.ClCCl.O=C(O)C(F)(F)F>>CCc1nc2ccc(C(O)(c3cnnn3C)C3CNC3)cc2c(Cl)c1OCC1CC1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CCc1cccc(CC)c1N=C=O.CN(C)C=O.CN1CCC(Oc2ccc(-c3n[nH]c4ccc(N)cc34)cc2)CC1.CO.C[O-].O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.[Na+]>>CCc1cccc(CC)c1NC(=O)Nc1ccc2[nH]nc(-c3ccc(OC4CCN(C)CC4)cc3)c2c1",
        "output": "473"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)N.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3cccc(C(=O)O)c3)nc12)C(=O)N1CC(C#N)C1.F[P-](F)(F)(F)(F)F>>CC(C)NC(=O)c1cccc(-c2cnc3c(n2)c(C(=O)N[C@H](C)C(=O)N2CC(C#N)C2)cn3COCC[Si](C)(C)C)c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1c(Cl)cc(C(C)(C)C)c(O)c1C(=O)O.Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1>>Cc1c(Cl)cc(C(C)(C)C)c(O)c1C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1",
        "output": "50"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.NC1CCCCC1.O.O=C(Cl)c1cccnc1Cl>>O=C(NC1CCCCC1)c1cccnc1Cl",
        "output": "353"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].COc1cccc(B(O)O)c1.O.O=C(O)c1cccc(I)c1.O=C([O-])[O-].[Na+].[Na+].[Pd+2]>>COc1cccc(-c2cccc(C(=O)O)c2)c1",
        "output": "855"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.OCc1cccc2c(C(F)(F)F)c(O[C@@H]3CC[C@H](C(F)(F)F)CC3)ccc12>>O=Cc1cccc2c(C(F)(F)F)c(O[C@@H]3CC[C@H](C(F)(F)F)CC3)ccc12",
        "output": "179"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CCOC(=O)CC1CC2COCC(C1O)N2C(=O)OC(C)(C)C.ClCCl>>CCOC(=O)CC1CC2COCC(C1=O)N2C(=O)OC(C)(C)C",
        "output": "650"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc(I)cc1.C1CCC2CCCCC2C1.ClC(Cl)Cl.[Cu].[K+].[OH-].c1ccc2c(c1)Nc1ccccc1-c1ccccc1-2>>Ic1ccc(N2c3ccccc3-c3ccccc3-c3ccccc32)cc1",
        "output": "894"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)NS(=O)(=O)c1ccccc1N.Cc1ccccc1.Nc1cc(Cl)ccn1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)NS(=O)(=O)c1ccccc1Nc1ccnc(N)c1",
        "output": "115"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)Cn1ccc2ccc(OCCc3cnc(-c4ccc(C(F)(F)F)cc4)nc3C3CC3)cc21.[Li+].[OH-]>>O=C(O)Cn1ccc2ccc(OCCc3cnc(-c4ccc(C(F)(F)F)cc4)nc3C3CC3)cc21",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCN.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=Cc1c(F)cc(C(F)(F)F)cc1C(F)(F)F>>CCCCN=Cc1c(F)cc(C(F)(F)F)cc1C(F)(F)F",
        "output": "52"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.CC1(C)OB(c2ccc(N)nc2)OC1(C)C.CCN(CC)CC.ClCCl>>CC(=O)Nc1ccc(B2OC(C)(C)C(C)(C)O2)cn1",
        "output": "394"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCOc1cccc(Oc2ccc3c(c2)C=C(C(=O)OC)CCS3(=O)=O)c1.CO.Cl.O=C([O-])[O-].[K+].[K+]>>CCCOc1cccc(Oc2ccc3c(c2)C=C(C(=O)O)CCS3(=O)=O)c1",
        "output": "58"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1sc(C2(CN)CCOCC2)nc1-c1ccccc1.O=C(O)c1cccc(-c2noc(C(F)(F)F)n2)c1>>Cc1sc(C2(CNC(=O)c3cccc(-c4noc(C(F)(F)F)n4)c3)CCOCC2)nc1-c1ccccc1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)N1CCCOc2cc(N)ccc21.CNC(=O)c1sccc1Nc1nc(Cl)ncc1Cl>>CCOC(=O)N1CCCOc2cc(Nc3ncc(Cl)c(Nc4ccsc4C(=O)NC)n3)ccc21",
        "output": "808"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCN(CC)CC.Nc1ccc(-c2cc(-c3nc4ccccc4[nH]3)n[nH]2)cc1.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)Nc1ccc(-c2cc(-c3nc4ccccc4[nH]3)n[nH]2)cc1",
        "output": "473"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(O)C(=O)O.Cl.Nc1ncc(-c2nc(N3CCOCC3)c3sc(C4(O)CCNCC4)cc3n2)cn1>>CC(C)(O)C(=O)N1CCC(O)(c2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CO.COCCCOc1cc(C(=O)[C@@H](C/C=C/C[C@H](C(=O)N(C)C)C(C)C)C(C)C)ccc1OC.[BH4-].[Cl-].[NH4+].[Na+]>>COCCCOc1cc(C(O)[C@@H](C/C=C/C[C@H](C(=O)N(C)C)C(C)C)C(C)C)ccc1OC",
        "output": "24"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C1CCC2CN(C(=O)OC)CC(=O)N21.COC(=O)C(NC(=O)CN(CC(=O)NCC(=O)c1ccc(Br)cc1)C(=O)OC(C)(C)C)C(C)C>>CC(C)C(NC(=O)CN(CC(=O)NCC(=O)c1ccc(Br)cc1)C(=O)OC(C)(C)C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.ClCCl.NCCCCl.O=C(Cl)c1ccc([N+](=O)[O-])cc1>>O=C(NCCCCl)c1ccc([N+](=O)[O-])cc1",
        "output": "271"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(O)c1ccccn1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(OS(C)(=O)=O)c1ccccn1",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC(C)(CN)CO.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cn1nc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)c2ccc(F)cc21.F[B-](F)(F)F.O>>Cn1nc(-c2cnc3c(n2)c(C(=O)NCC(C)(C)CO)cn3COCC[Si](C)(C)C)c2ccc(F)cc21",
        "output": "737"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.O=[N+]([O-])c1ccc(-c2nc(C3CC3)[nH]c2-c2ccc(F)cc2F)nc1O>>Nc1ccc(-c2nc(C3CC3)[nH]c2-c2ccc(F)cc2F)nc1O",
        "output": "269"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)Cl.ClCCl.O=C(Cc1ccc(Cl)c(Cl)c1)N1CCNC2CCCC(N3CCCC3)C21>>CCOC(=O)N1CCN(C(=O)Cc2ccc(Cl)c(Cl)c2)C2C(N3CCCC3)CCCC21",
        "output": "219"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)[C@@H]1C[C@H]1c1ccccc1.CO.O.[K+].[OH-]>>O=C(O)[C@@H]1C[C@H]1c1ccccc1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCOP(=O)(C#N)OCC.CN(C)C=O.O.O=C(O)Cc1ccc(OCc2ccccc2)cc1OCc1ccccc1.c1ccc(CC2CCNCC2)cc1>>O=C(Cc1ccc(OCc2ccccc2)cc1OCc1ccccc1)N1CCC(Cc2ccccc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CC2CC1CN2.CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)cc1.[K+].[K+]>>CC(C)(C)OC(=O)N1CC2CC1CN2c1ccc([N+](=O)[O-])cc1",
        "output": "26"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c(Cl)c1.OCc1ccccn1.[K+].[K+]>>O=[N+]([O-])c1ccc(OCc2ccccn2)c(Cl)c1",
        "output": "485"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.NC1(c2ccccc2)CCCCC1.O=C(Cl)CCCCl.c1ccncc1>>O=C(CCCCl)NC1(c2ccccc2)CCCCC1",
        "output": "206"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.C[Si](C)(C)C#Cc1cncc(C2(C(N)=S)C[C@H]3C=C[C@@H](C2)N3CC(F)(F)F)c1.O=C([O-])O.O=C([O-])[O-].[K+].[K+].[Na+]>>C#Cc1cncc(C2(C(N)=S)C[C@H]3C=C[C@@H](C2)N3CC(F)(F)F)c1",
        "output": "337"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CO.COC(=O)c1ccc(CC=O)cc1.Clc1ccc(C(c2ccc(Cl)cc2)c2ccc3ncnc(NC4CCNCC4)c3c2)cc1.[BH3-]C#N.[Na+]>>COC(=O)c1ccc(CCN2CCC(Nc3ncnc4ccc(C(c5ccc(Cl)cc5)c5ccc(Cl)cc5)cc34)CC2)cc1",
        "output": "484"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CO.COc1ccc(Cn2nc3c(Cl)nc4cc(C#N)ccc4c3c2C)cc1.Cl.Nc1ccc2cn[nH]c2c1>>Cc1[nH]nc2c(Nc3ccc4cn[nH]c4c3)nc3cc(C#N)ccc3c12",
        "output": "998"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)CC1.CN(C)C=O.Cc1cc(F)ccc1C#N.[H-].[Na+]>>Cc1cc(OC2CCN(C(=O)OC(C)(C)C)CC2)ccc1C#N",
        "output": "485"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(CNc2nccs2)(C2CCCCC2)CC1.ClCCl.O.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F>>c1csc(NCC2(C3CCCCC3)CCNCC2)n1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COc1nc(C)nc(C(F)(F)F)c1C#C[Si](C)(C)C.O.[F-]>>C#Cc1c(OC)nc(C)nc1C(F)(F)F",
        "output": "337"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)c1cc(OC(F)(F)F)cc(N2CCCC2)c1>>O=C(Cl)c1cc(OC(F)(F)F)cc(N2CCCC2)c1",
        "output": "448"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCC(c1ccc(C(=O)OC)cc1)n1ccc([N+](=O)[O-])n1.CCOC(C)=O.CO.NN.O.[Ni]>>CCCC(c1ccc(C(=O)OC)cc1)n1ccc(N)n1",
        "output": "684"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1cc(=O)n(CCN2CCC(N(Cc3ccc4c(c3)OCCO4)C(=O)OC(C)(C)C)CC2)c2cc(C(=O)O)ccc12.Cl.ClCCl.F[P-](F)(F)(F)(F)F.O>>CNC(=O)c1ccc2c(C)cc(=O)n(CCN3CCC(N(Cc4ccc5c(c4)OCCO5)C(=O)OC(C)(C)C)CC3)c2c1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Clc1ccc2nc(Cl)nc(NCc3ccc4c(c3)OCO4)c2c1.N>>Nc1nc(NCc2ccc3c(c2)OCO3)c2cc(Cl)ccc2n1",
        "output": "312"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC1(C)CN(S(C)(=O)=O)CCN1.CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1.ClCCCl.[Na+]>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCN(S(C)(=O)=O)CC3(C)C)n(C)c2n1",
        "output": "944"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cnc3ccc(Oc4ccc(NC(=O)Nc5ccc(F)cc5)cc4)cc3n2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(Nc1ccc(F)cc1)Nc1ccc(Oc2ccc3ncc(N4CCNCC4)nc3c2)cc1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COc1cc(Br)ccc1-n1cnc(C)c1.ClCCl.ClCCl.Nc1nc2cccc(N3CCCC3)n2n1>>COc1cc(Nc2nc3cccc(N4CCCC4)n3n2)ccc1-n1cnc(C)c1",
        "output": "970"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(=O)Cl.COc1ccc(Cl)c(C)c1.Cl.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CCC(=O)c1cc(Cl)c(C)cc1OC",
        "output": "31"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](N)CC1.Cc1c(C(=O)O)c2ncnc(-c3cc(C(C)C)ccc3OCC3CC3)c2n1COCC[Si](C)(C)C>>Cc1c(C(=O)N[C@@H]2CC[C@@H](NC(=O)OC(C)(C)C)CC2)c2ncnc(-c3cc(C(C)C)ccc3OCC3CC3)c2n1COCC[Si](C)(C)C",
        "output": "737"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(Nc1nnc(COc2ccccc2Cl)s1)c1ccc2c(c1)CCNC2.O=C(O)CO>>O=C(Nc1nnc(COc2ccccc2Cl)s1)c1ccc2c(c1)CCN(C(=O)CO)C2",
        "output": "633"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCC(C(=O)OC)c1c(C)nc(Sc2ccccc2)nc1-c1ccc(C)cc1.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc(Sc2ccccc2)nc1-c1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[O-].CC(C)(C)c1ccc(Br)cc1.Cc1ccccc1.Nc1ccccc1-c1ccc(OC(F)(F)F)cc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Cl-].[K+].[NH4+].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)c1ccc(Nc2ccccc2-c2ccc(OC(F)(F)F)cc2)cc1",
        "output": "405"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(S(=O)(=O)NCC(C(=O)OC(C)(C)C)C2(CC(C)C)CCN(CCc3ccccc3)C2=O)cc1.ClCCl.ClCl.O.O=C(O)C(F)(F)F>>COc1ccc(S(=O)(=O)NCC(C(=O)O)C2(CC(C)C)CCN(CCc3ccccc3)C2=O)cc1",
        "output": "278"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCCCOc1ccc(Oc2ccccc2)cc1.CC(C)(C)[O-].CN(C)C=O.COC(=O)C(Cc1ccc(O)cc1)Oc1ccccc1.[K+]>>COC(=O)C(Cc1ccc(OCCCOc2ccc(Oc3ccccc3)cc2)cc1)Oc1ccccc1",
        "output": "75"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.COc1ccc(C(=O)Cl)cc1.Nc1ccc2c(c1)CCC2=O>>COc1ccc(C(=O)Nc2ccc3c(c2)CCC3=O)cc1",
        "output": "11"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.C[C@@H]1CC[C@@H](Oc2cc(C#N)ccn2)CN1.Cl.ClCCCl.O.O=C(O)c1ccccc1-n1nccn1.O=C([O-])O.On1nnc2cccnc21.[Na+]>>C[C@@H]1CC[C@@H](Oc2cc(C#N)ccn2)CN1C(=O)c1ccccc1-n1nccn1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)c1cn(CC)c2cc(Cl)c(F)cc2c1=O.CN1CCNCC1.Cc1ccccn1>>CCOC(=O)c1cn(CC)c2cc(N3CCN(C)CC3)c(F)cc2c1=O",
        "output": "280"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=CCBr.CC(C)=O.O.O=C(Cn1nc(C(F)F)cc1C(F)F)N1CCC(c2nc(C3=NOC(c4ccccc4O)C3)cs2)CC1.O=C([O-])[O-].[K+].[K+]>>C=CCOc1ccccc1C1CC(c2csc(C3CCN(C(=O)Cn4nc(C(F)F)cc4C(F)F)CC3)n2)=NO1",
        "output": "77"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(C)=O.CCc1cc2c(cc1N1CCC(=O)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O.Cl.NO>>CCc1cc2c(cc1N1CCC(=NO)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O",
        "output": "86"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(=O)(=O)CCCl.CS(=O)(=O)c1ccc(-c2cccn3nc(Nc4cccc(C5CCNCC5)c4)nc23)cc1>>CS(=O)(=O)CCN1CCC(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1",
        "output": "138"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.Cl.O=P(Cl)(Cl)Cl.c1csc(-c2cccs2)c1>>O=Cc1ccc(-c2cccs2)s1",
        "output": "617"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCN(CC)CC.Clc1ccc(Cl)nn1.NN>>NNc1ccc(Cl)nn1",
        "output": "284"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Nc1ccccn1.O=C(O)C(SC1CCCC1)c1ccc(F)c(F)c1>>O=C(Nc1ccccn1)C(SC1CCCC1)c1ccc(F)c(F)c1",
        "output": "368"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc(B2OC(C)(C)C(C)(C)O2)ccc1N.COc1ccc2[nH]c(=O)c3sccc3c2c1Br>>COc1cc(-c2c(OC)ccc3[nH]c(=O)c4sccc4c23)ccc1N",
        "output": "972"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC[C@H](C)Oc1cc(O[Si](C(C)C)(C(C)C)C(C)C)cc(-c2ccc(C(=O)O)[nH]2)c1.COc1nc(OC)nc([N+]2(C)CCOCC2)n1.C[C@H](O)[C@@H](N)CO.[Cl-]>>COC[C@H](C)Oc1cc(O[Si](C(C)C)(C(C)C)C(C)C)cc(-c2ccc(C(=O)N[C@@H](CO)[C@H](C)O)[nH]2)c1",
        "output": "137"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O.O=C(O)/C=C/c1ccccc1O.[Li+].[OH-].c1c[nH]cn1>>CC(C)(C)[Si](C)(C)Oc1ccccc1/C=C/C(=O)O",
        "output": "746"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)CI.CN(C)C=O.COc1cccc(C=O)c1O.O=C([O-])[O-].[K+].[K+]>>COc1cccc(C=O)c1OCC(C)C",
        "output": "198"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=C1CCN(c2ccc([N+](=O)[O-])cc2)CC1.[Pd]>>Nc1ccc(N2CCC(=O)CC2)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COC(=O)[C@H](Cc1ccc(-c2cccc(C(F)(F)F)c2)cc1)NC(=O)c1cc(-c2ccc(F)c(Cl)c2)ccc1O.Cl.[Li+].[OH-]>>O=C(N[C@@H](Cc1ccc(-c2cccc(C(F)(F)F)c2)cc1)C(=O)O)c1cc(-c2ccc(F)c(Cl)c2)ccc1O",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)Nc1ncc2c(n1)CN(C(=O)NC(CCNC(=O)OC(C)(C)C)c1ccc(Cl)c(Cl)c1)CC2>>CNCCC(NC(=O)N1CCc2cnc(NC(C)C)nc2C1)c1ccc(Cl)c(Cl)c1",
        "output": "881"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.C[C@@H]1CNC[C@H]2Cc3ccc([C@@H](C)O)nc3N12.ClCCl>>C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3ccc([C@@H](C)O)nc3N12",
        "output": "694"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl.O=C(Nc1ccc(Cl)cc1)C1CNCC(F)(F)C1.O=C(O)c1cncc(-c2ccco2)c1>>O=C(Nc1ccc(Cl)cc1)C1CN(C(=O)c2cncc(-c3ccco3)c2)CC(F)(F)C1",
        "output": "256"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)N1CCC(N)CC1.CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].CCO.O=Cc1cc([N+](=O)[O-])ccc1F.[BH4-].[Na+].[Ti+4]>>CC(C)(C)OC(=O)N1CCC(NCc2cc([N+](=O)[O-])ccc2F)CC1",
        "output": "468"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "B.C1CCOC1.C1CCOC1.O=C(O)c1ccc(C(F)(F)F)nc1Cl>>OCc1ccc(C(F)(F)F)nc1Cl",
        "output": "293"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(=O)OCc1ccccc1)C1CCNCC1.CCOc1cc(Br)ccc1-c1nc2c(C)nn(C3CCCCC3)c2c(=O)[nH]1.Cl>>CCOc1cc(N2CCC(N(CC)C(=O)OCc3ccccc3)CC2)ccc1-c1nc2c(C)nn(C3CCCCC3)c2c(=O)[nH]1",
        "output": "294"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.NCC(O)CN1CCc2ccccc2C1.O=C(O)COc1ccccc1>>O=C(COc1ccccc1)NCC(O)CN1CCc2ccccc2C1",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C1(c2ccc3ccccc3c2)CCC2(CC1)OCCO2.Cl.Cl>>CN(C)C1(c2ccc3ccccc3c2)CCC(=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.Cc1cccc(Cl)c1Nc1nc2cc(C(=O)O)c3c(c2[nH]1)CC(C)(C)O3.Nc1cc(C(F)(F)F)ccc1F.O=S(Cl)Cl>>Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3cc(C(F)(F)F)ccc3F)c3c(c2[nH]1)CC(C)(C)O3",
        "output": "50"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "NCCCCN1CCC2(CC1)OCCO2.O=C(O)C=Cc1cccnc1.O=C(n1ccnc1)n1ccnc1>>O=C(C=Cc1cccnc1)NCCCCN1CCC2(CC1)OCCO2",
        "output": "549"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.CCO.Cc1c(N)cccc1Cl>>CC(=O)Nc1cccc(Cl)c1C",
        "output": "6"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCCBr.CC#N.N#Cc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>N#Cc1ccc(OCCBr)cc1",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CN(CCc1ccccc1)C(=O)Cn1ccc(CO)c1.ClCCl.O=S(Cl)Cl.c1ccncc1>>CN(CCc1ccccc1)C(=O)Cn1ccc(CCl)c1",
        "output": "477"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1ccc(COc2ccc(Cn3cnc4cc(-c5nnc(C6CCN(C(=O)OC(C)(C)C)CC6)o5)ccc43)cc2OC)cn1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(COc2ccc(Cn3cnc4cc(-c5nnc(C6CCNCC6)o5)ccc43)cc2OC)cn1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.Cl.ClCCl.O=C(O)CCCBr.Oc1c(F)c(F)c(F)c(F)c1F>>O=C(CCCBr)Oc1c(F)c(F)c(F)c(F)c1F",
        "output": "108"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1ccccc1.O=C(O)c1ncccc1O.O=S(=O)(O)O>>CCOC(=O)c1ncccc1O",
        "output": "331"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCN(CCCCC(O)c3ccccc3)CC2)c1.Cl.Oc1ccc(Cl)cc1>>CC(C)C(=O)Nc1cccc(C2CCN(CCCCC(Oc3ccc(Cl)cc3)c3ccccc3)CC2)c1",
        "output": "342"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(=O)CNS(=O)(=O)c1ccc2c(c1)oc1ccc(Br)cc12.CS(C)=O.[K+]>>COC(=O)CNS(=O)(=O)c1ccc2c(c1)oc1ccc(B3OC(C)(C)C(C)(C)O3)cc12",
        "output": "942"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCCCCCC#Cc1ccc(-c2ccc(C(=O)OC)cc2)cc1.CO.[Pd]>>CCCCCCCCCc1ccc(-c2ccc(C(=O)OC)cc2)cc1",
        "output": "717"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.NN.O.O=C(O)c1ccc(O)c(O)c1.O=c1ccccn1O>>NNC(=O)c1ccc(O)c(O)c1",
        "output": "55"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cc(-c3ccc4c(c3)C(C)(C)CCC4(C)C)no2)CC1.ClCCl.O=C(O)C(F)(F)F>>CC1(C)CCC(C)(C)c2cc(-c3cc(N4CCNCC4)on3)ccc21",
        "output": "575"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CN1CCN(C)C1=O.CS(=O)(=O)Nn1c(=O)[nH]c2cc([N+](=O)[O-])c(F)cc2c1=O.O.c1c[nH]cn1>>CS(=O)(=O)Nn1c(=O)[nH]c2cc([N+](=O)[O-])c(-n3ccnc3)cc2c1=O",
        "output": "701"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1nc2c(cc1NC(=O)Oc1ccccc1)CCC2.Cc1cc(C)cc(N2CCNCC2)c1>>COc1nc2c(cc1NC(=O)N1CCN(c3cc(C)cc(C)c3)CC1)CCC2",
        "output": "525"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)N1CCN(C(CN2CCNCC2)c2ccc(F)cc2)CC1.ClCCl.N#Cc1ccc(-c2ccccc2CCC=O)cc1.O=C([O-])O.[Na+].[Na+]>>CC(C)N1CCN(C(CN2CCN(CCCc3ccccc3-c3ccc(C#N)cc3)CC2)c2ccc(F)cc2)CC1",
        "output": "484"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CSc1ccc(O)cc1C.CN(C)C=O.Cc1ccc(S(=O)(=O)OCC[C@H](C)O)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>CCOC(=O)CSc1ccc(OCC[C@H](C)O)cc1C",
        "output": "438"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CS(=O)(=O)c1sc(Cl)c2c1-c1nc(N)sc1CC2.Cc1cc(Cl)cc(Cl)c1S(=O)(=O)Cl>>Cc1cc(Cl)cc(Cl)c1S(=O)(=O)Nc1nc2c(s1)CCc1c(Cl)sc(S(C)(=O)=O)c1-2",
        "output": "637"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)CSCCC1CN=C(c2cc3cccc(N(C)S(=O)(=O)c4cccs4)c3[nH]2)S1.CO.Cl.O.[K+].[OH-]>>CN(c1cccc2cc(C3=NCC(CCSCC(=O)O)S3)[nH]c12)S(=O)(=O)c1cccs1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C(=O)NCc1ccc(C(F)(F)F)nc1N1CCCC1)c1ccc(CN)c(Cl)c1.CS(=O)(=O)Cl.ClCCl.c1ccncc1>>CC(C(=O)NCc1ccc(C(F)(F)F)nc1N1CCCC1)c1ccc(CNS(C)(=O)=O)c(Cl)c1",
        "output": "742"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.N#Cc1ccc(NC(=O)CCl)cc1.c1ccc(CC2CCNCC2)cc1>>N#Cc1ccc(NC(=O)CN2CCC(Cc3ccccc3)CC2)cc1",
        "output": "340"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.O=[N+]([O-])c1c(Cl)ncnc1Cl>>Nc1c(Cl)ncnc1Cl",
        "output": "660"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCCc1nc2ccccc2s1.Fc1cccc(Br)n1>>Fc1cccc(C#CCCc2nc3ccccc3s2)n1",
        "output": "777"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCC.CCOC(C)=O.COC(=O)C1(NC(=O)c2ccc(-c3ccc(OC)cc3)cc2N)CCCCCCC1.Cc1cc(C)c(N=C=O)c(C)c1.c1ccncc1>>COC(=O)C1(NC(=O)c2ccc(-c3ccc(OC)cc3)cc2NC(=O)Nc2c(C)cc(C)cc2C)CCCCCCC1",
        "output": "993"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COc1cc(CCN(C(=O)OC(C)(C)C)[C@@H](C)C2CCN(C(=O)C3CC3)CC2)c(Cl)cc1N.N#Cc1cnc(NC(=O)Oc2ccccc2)cn1>>COc1cc(CCN(C(=O)OC(C)(C)C)[C@@H](C)C2CCN(C(=O)C3CC3)CC2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1",
        "output": "948"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCCl.O=C([O-])O.O=C1[C@@H](N2CC[C@H](c3cc(Cl)cc(Cl)c3)C2)CCN1c1ccccc1.O=S(=O)(O)Cl.[Na+]>>O=C1[C@@H](N2CC[C@H](c3cc(Cl)cc(Cl)c3)C2)CCN1c1ccc(S(=O)(=O)Cl)cc1",
        "output": "182"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CS(C)=O.N#CC1(Cn2cnc3ccc(-c4cc(F)ncc4Cl)cc32)CCOCC1.NCCO>>N#CC1(Cn2cnc3ccc(-c4cc(NCCO)ncc4Cl)cc32)CCOCC1",
        "output": "810"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1ccc(C=O)cc1NC(=O)c1ccc(Nc2nc(-c3ccccc3)c3ccccc3n2)cc1.ClCCl.NC1CC1.[Na+]>>Cc1ccc(CNC2CC2)cc1NC(=O)c1ccc(Nc2nc(-c3ccccc3)c3ccccc3n2)cc1",
        "output": "468"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)CCCCC1(C)c2ccccc2-c2[nH]c(=O)c3nccn3c21.Cl.[Na+].[OH-]>>CC1(CCCCC(=O)O)c2ccccc2-c2[nH]c(=O)c3nccn3c21",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nnn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1.CCO.CCOC(C)=O.Cc1ccccc1>>CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2nnn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1",
        "output": "287"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(Br)cc23)cc1.Cl.Nc1ccc(N2CCOCC2)cc1>>Brc1ccc2nc(Nc3ccc(N4CCOCC4)cc3)c3n[nH]cc3c2c1",
        "output": "998"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cc1cc(C)c(CN)c(=O)[nH]1.Cc1nn(C(C)C)c2cc(-c3cccnc3)cc(C(=O)O)c12.Cl.ClCCl.On1nnc2ccccc21>>Cc1cc(C)c(CNC(=O)c2cc(-c3cccnc3)cc3c2c(C)nn3C(C)C)c(=O)[nH]1",
        "output": "334"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cl.Nc1ccc(C(=O)O)cc1.O=C(Cl)CCl.[Na+].[OH-]>>O=C(CCl)Nc1ccc(C(=O)O)cc1",
        "output": "9"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCC/C=C/C(=O)O.CN(C)CCNCCN(C)C>>CCCCCCC/C=C/C(=O)N(CCN(C)C)CCN(C)C",
        "output": "870"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)Cl.O.O=C(O)c1ccc(Br)nc1.[BH4-].[Na+]>>OCc1ccc(Br)nc1",
        "output": "293"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cl.Cl.O=C(O)CC1CN(Cc2ccccc2Cl)CCC1=O>>COC(=O)CC1CN(Cc2ccccc2Cl)CCC1=O",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@H](C(=O)O)C(C)(C)C.CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)CCC(=O)N[C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C.COC(=O)c1ccc(CO[C@@H]2CCN[C@H](C(=O)N[C@@H]3CCCc4ccccc43)C2)cc1>>COC(=O)c1ccc(CO[C@@H]2CCN(C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)[C@H](C(=O)N[C@@H]3CCCc4ccccc43)C2)cc1",
        "output": "297"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CN1C(=O)c2cccc3cccc(c23)C1=S.CO.[Na+].[OH-]>>O=C(O)CN1C(=O)c2cccc3cccc(c23)C1=S",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)OB(c2cc(F)c(O)c(Cl)c2)OC1(C)C.CCCC(=O)c1cnc2ccc(Br)cc2c1N[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1>>CCCC(=O)c1cnc2ccc(-c3cc(F)c(O)c(Cl)c3)cc2c1N[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)CC1",
        "output": "933"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)OB(OC(C)C)OC(C)C.COc1ccc(Br)cc1F.[Li]CCCC>>COc1ccc(B(O)O)cc1F",
        "output": "832"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCc1c(OCCCN(C)C(=O)Nc2ccc(C(=O)OC)cn2)ccc2c(C(F)(F)F)noc12.CO.[Na+].[OH-]>>CCCc1c(OCCCN(C)C(=O)Nc2ccc(C(=O)O)cn2)ccc2c(C(F)(F)F)noc12",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CC(C)I.Nc1c(O)c(Cl)cc(F)c1-n1nnn(CCCF)c1=O.O=C([O-])[O-].[K+].[K+]>>CC(C)Oc1c(Cl)cc(F)c(-n2nnn(CCCF)c2=O)c1N",
        "output": "318"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O.O=C(c1ccccc1)c1ccc(I)c([N+](=O)[O-])c1.O=S([O-])S(=O)[O-].[Na+].[Na+].c1ccncc1>>Nc1cc(C(=O)c2ccccc2)ccc1I",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC.Cl.[N-]=[N+]=NCCOCCOCCOCCN=[N+]=[N-].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>[N-]=[N+]=NCCOCCOCCOCCN",
        "output": "89"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C#Cc1cccc(OC)c1.CCN(CC)CC.Cc1ccc(N)c(Br)n1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>COc1cccc(C#Cc2nc(C)ccc2N)c1",
        "output": "777"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CNCCN1.CCO.CCOc1nc(Cl)nc(N2CCS(=O)CC2)c1[N+](=O)[O-].O>>CCOc1nc(N2CCNCC2)nc(N2CCS(=O)CC2)c1[N+](=O)[O-]",
        "output": "36"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CN(C)c1ccncc1.Nc1nc(C2CCNCC2)c2ccccc2n1.O=C(O)Cc1ccc(O)c(O)c1>>Nc1nc(C2CCN(C(=O)Cc3ccc(O)c(O)c3)CC2)c2ccccc2n1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc(Br)cc(OC)c1.CS(C)=O.[C-]#N.[K+]>>COc1cc(O)cc(Br)c1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1cn(-c2nccc3ccccc23)cc1C.O.O.[Li+].[OH-]>>Cc1cn(-c2nccc3ccccc23)cc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1nc2c(cc1NC(=O)Oc1ccccc1)CCCC2.Cc1cc(C)cc(N2CCNCC2)c1>>COc1nc2c(cc1NC(=O)N1CCN(c3cc(C)cc(C)c3)CC1)CCCC2",
        "output": "525"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[Si](C)(C)Cl.Cc1c(F)cccc1NC(=S)Nc1ccc(Cl)c(S(=O)(=O)N(C)C)c1O.NC(=S)Nc1ccccc1.c1c[nH]cn1>>Cc1c(F)cccc1NC(=S)Nc1ccc(Cl)c(S(=O)(=O)N(C)C)c1O[Si](C)(C)C(C)(C)C",
        "output": "746"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.ClCCl.N#N.O.OCc1coc(/C=C/c2ccccc2)n1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCc1coc(/C=C/c2ccccc2)n1",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1ccc2nc(-c3ccc(F)cc3)c(N(C)C3CCCC3)nc2c1.O.[Na+].[OH-]>>CN(c1nc2cc(C(=O)O)ccc2nc1-c1ccc(F)cc1)C1CCCC1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(O)Cc1cc2c(cc1C(=NNc1ncccn1)c1ccc([N+](=O)[O-])cc1)OCO2.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(Cc1cc2c(cc1C(=NNc1ncccn1)c1ccc([N+](=O)[O-])cc1)OCO2)OS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)Oc1cc([N+](=O)[O-])ccc1N1CCN(C)CC1.CO.[Pd]>>CC(C)Oc1cc(N)ccc1N1CCN(C)CC1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1nc(Cl)c2nc(-c3ccccc3)cc-2[nH]1.ClCCl.NCC(F)(F)F.O.O=C([O-])[O-].[K+].[K+]>>Cc1nc(NCC(F)(F)F)c2nc(-c3ccccc3)cc-2[nH]1",
        "output": "148"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.CON.Cl.O=C(N[C@H]1CCCCC1=O)c1cnc(OCC2CC2)c(-c2ccc(Cl)cc2)c1>>CO/N=C1\\CCCC[C@@H]1NC(=O)c1cnc(OCC2CC2)c(-c2ccc(Cl)cc2)c1",
        "output": "86"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O=C(Nc1ccc(F)cc1)N1CCNCC1.O=Cc1ccc2ccccc2n1>>O=C(Nc1ccc(F)cc1)N1CCN(Cc2ccc3ccccc3n2)CC1",
        "output": "829"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.Cc1ccc(N)cc1Br.ClCCl.O=C(Cl)c1cccc(C(F)(F)F)c1.O=C([O-])O.[Na+]>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Br",
        "output": "11"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOP(=O)(CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)OCC.C[Si](C)(C)Br.ClCCl>>O=P(O)(O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F",
        "output": "535"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN1CCOCC1.C[C@H](NC(=O)OC(C)(C)C)C(=O)O.Cl.ClCCl.Nc1ccc(F)cc1Nc1ccccn1.O=C([O-])O.On1nnc2cccnc21.[Na+]>>C[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc(F)cc1Nc1ccccn1",
        "output": "365"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1ccc(O)cc1.CCN(CC)CC.COCCl.ClCCl>>COCOc1ccc(C(C)=O)cc1",
        "output": "375"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CCC[N+](CCC)(CCC)CCC.C[C@H]1CN(c2nc(F)ccc2CO)C[C@@H](C)O1.C[N+]1([O-])CCOCC1.ClCCl.O=[Ru](=O)(=O)[O-]>>C[C@H]1CN(c2nc(F)ccc2C=O)C[C@@H](C)O1",
        "output": "520"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(O)C(CO)C(C)O.CCCCCCCCCCCCCCCCNc1ccc(C(=O)Cl)cc1.CN(C)c1ccncc1.COCCOC.Cl.ClC(Cl)Cl.ClCc1ccccc1.O.[H-].[H][H].[Na+]>>CCCCCCCCCCCCCCCCNc1ccc(C(=O)OC(C)C(CO)C(C)O)cc1",
        "output": "51"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.COC(=O)c1cc2nc(-c3ccccc3)sc2cc1OC.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>COc1cc2sc(-c3ccccc3)nc2cc1CO",
        "output": "444"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Brc1cncc2[nH]ncc12.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1cc(Br)c2cn[nH]c2c1",
        "output": "820"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.C1CCOC1.c1ccc(CNCC2CCNCC2)cc1>>c1ccc(CNCC2CCN(Cc3ccccc3)CC2)cc1",
        "output": "248"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)C1Cc2nccnc2C1.CCOCC.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>OCC1Cc2nccnc2C1",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Brc1cnc2nc(COc3ccccn3)cn2c1.Cc1ccc(F)cc1B(O)O>>Cc1ccc(F)cc1-c1cnc2nc(COc3ccccn3)cn2c1",
        "output": "871"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C=Cc1cn(COCC[Si](C)(C)C)c2ncnc(N3CCC[C@H]3c3nn4cccc4c(=O)n3-c3ccccc3)c12.O=C(O)C(F)(F)F>>C=Cc1c[nH]c2ncnc(N3CCC[C@H]3c3nn4cccc4c(=O)n3-c3ccccc3)c12",
        "output": "897"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(C(=O)Nc2ccccc2NC(=O)C2CCNCC2)cc1.O=Cc1ccc2c(c1)OCO2>>COc1ccc(C(=O)Nc2ccccc2NC(=O)C2CCN(Cc3ccc4c(c3)OCO4)CC2)cc1",
        "output": "567"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCC.O=C1NC2CC3CC(C2)CC1C3.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>C1NC2CC3CC1CC(C3)C2",
        "output": "112"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCO.O=C([O-])[O-].O=C1OC(CCCCCl)CN1c1ccccc1.[I-].[K+].[K+].[K+].c1ccc(N2CCNCC2)nc1>>O=C1OC(CCCCN2CCN(c3ccccn3)CC2)CN1c1ccccc1",
        "output": "138"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Br.COc1ccc2nccc(Cl)c2c1.O.[Na+].[OH-]>>Oc1ccc2nccc(Cl)c2c1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(CCN)cc1.O=C(O)Cn1cc(-c2ccc(Cl)cc2Cl)nc1C=C1c2ccccc2-c2ccccc21>>COc1ccc(CCNC(=O)Cn2cc(-c3ccc(Cl)cc3Cl)nc2C=C2c3ccccc3-c3ccccc32)cc1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCC1CCCCC1.CCCCCC.CCOC(C)=O.CN(C)C=O.Cc1ccc(C(=O)c2c[nH]c3ccccc3c2=O)cc1C.[H-].[Na+]>>Cc1ccc(C(=O)c2cn(CC3CCCCC3)c3ccccc3c2=O)cc1C",
        "output": "470"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCCCC1.C1CCOC1.Fc1cccc(-c2ccc3ccccc3c2)c1.II.O.[Li]C(C)CC>>Fc1cc(-c2ccc3ccccc3c2)ccc1I",
        "output": "372"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CS(=O)(=O)N1CCC(Oc2ccc3ncnc(Cl)c3c2)CC1.Cn1ccnc1Sc1ccc(N)cc1F>>Cn1ccnc1Sc1ccc(Nc2ncnc3ccc(OC4CCN(S(C)(=O)=O)CC4)cc23)cc1F",
        "output": "352"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrP(Br)Br.CCOCC.CS(=O)(=O)c1ccc(CO)cc1F.O>>CS(=O)(=O)c1ccc(CBr)cc1F",
        "output": "300"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)Cn1c(COCc2ccccc2)nc(C(C)C)c1Sc1cc(Cl)cc(Cl)c1.C[Mg]Br.[Cl-].[NH4+]>>CC(C)c1nc(COCc2ccccc2)n(CC(C)(C)O)c1Sc1cc(Cl)cc(Cl)c1",
        "output": "514"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C#CCCCO.CC(C)(C)OC(=O)NCCCc1cccc(Br)c1>>CC(C)(C)OC(=O)NCCCc1cccc(C#CCCCO)c1",
        "output": "659"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.NCC1CCC(CN(Cc2ccccc2)S(=O)(=O)NC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1.O=C=Nc1ccccc1>>O=C(NCC1CCC(CN(Cc2ccccc2)S(=O)(=O)NC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1)Nc1ccccc1",
        "output": "35"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Cl.Nc1cccc(C2CCCC2)c1.O.O=N[O-].[I-].[K+].[Na+].[Na+].[OH-]>>Ic1cccc(C2CCCC2)c1",
        "output": "200"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.O=C(NC1(C(=O)NC2CCN(c3ccccc3[N+](=O)[O-])CC2O)CCCCC1)c1cc2ccccc2o1.[H][H].[Pd]>>Nc1ccccc1N1CCC(NC(=O)C2(NC(=O)c3cc4ccccc4o3)CCCCC2)C(O)C1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cc(C=C2CCN(C(=O)OC(C)(C)C)CC2)cc(Oc2ccc(C(F)(F)F)cn2)c1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(C=C2CCNCC2)cc(Oc2ccc(C(F)(F)F)cn2)c1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)Nc1cc(Cl)cc(Br)c1F.Cl>>Nc1cc(Cl)cc(Br)c1F",
        "output": "782"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C.CCOC(C)=O.C[Si](C)(C)Oc1ccc(-c2ccc(C=CCCCO)cc2)nc1.[Pd]>>C[Si](C)(C)Oc1ccc(-c2ccc(CCCCCO)cc2)nc1",
        "output": "362"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CN(C(=O)OC(C)(C)C)c1cccc(Nc2nc(Cl)ncc2F)c1.COCCOCOCCOc1ccc(N)cc1.O.O=C([O-])[O-].[Cs+].[Cs+]>>COCCOCOCCOc1ccc(Nc2ncc(F)c(Nc3cccc(N(C)C(=O)OC(C)(C)C)c3)n2)cc1",
        "output": "907"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COCCNCCc1ccc(Br)nc1.ClCCl>>COCCN(CCc1ccc(Br)nc1)C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)OCC(CCCCO)O1.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCCCCC2COC(C)(C)O2)cc1",
        "output": "197"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CCSCc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(NCc3cccc(C(F)(F)F)c3)ncn2)c1.CC(Cl)Cl.O=C(O)C(F)(F)F>>O=C(O)CCSCc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(NCc3cccc(C(F)(F)F)c3)ncn2)c1",
        "output": "278"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCCCC/C=C\\CCCCCCCC(=O)OCC(O)CO.O=C(O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12.O=P(Cl)(Cl)Cl.c1ccncc1>>CCCCCCCC/C=C\\CCCCCCCC(=O)OCC(O)COC(=O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN=C=NCCCN(C)C.CCOC(=O)CCN.CN1CCOCC1.Cl.Cl.ClCCl.O.O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)O)OCc1ccccc1.On1nnc2ccccc21>>CCOC(=O)CCNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1ccc2nc(-c3ccccc3)c(Cl)nc2c1.N#Cc1ccc(B(O)O)cc1>>COC(=O)c1ccc2nc(-c3ccccc3)c(-c3ccc(C#N)cc3)nc2c1",
        "output": "875"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCCCCCCCCCCCCCCC(=O)O.CN(C)CCCN.[BH4-].[Na+]>>CCCCCCCCCCCCCCCCCC(=O)NCCCN(C)C",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCO.CCCn1ncc2cc(C(=O)CC(=O)OCC)ccc21.Cc1ccc(S(=O)(=O)O)cc1.Cc1cnc(-c2cn[nH]c2N)o1>>CCCn1ncc2cc(-c3cc(=O)n4ncc(-c5ncc(C)o5)c4[nH]3)ccc21",
        "output": "513"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1cccc(OCCCN)c1.Cc1cccc(-c2cc(Cl)nc(N)n2)c1C>>CC(=O)Nc1cccc(OCCCNc2cc(-c3cccc(C)c3C)nc(N)n2)c1",
        "output": "166"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.BrBr.CC(=O)O.CON=C(C(C)=O)C(=O)O.ClCCl>>CON=C(C(=O)O)C(=O)CBr",
        "output": "173"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(C)CCC(C)(C)c2cc(-c3coc(CCc4ccc([N+](=O)[O-])cc4)n3)ccc21.CCOC(C)=O.O.O=C([O-])O>>CC1(C)CCC(C)(C)c2cc(-c3coc(CCc4ccc(N)cc4)n3)ccc21",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Nc1ccc(O)cc1[N+](=O)[O-].O=[N+]([O-])c1ccc(F)cc1.[H-].[Na+]>>Nc1ccc(Oc2ccc([N+](=O)[O-])cc2)cc1[N+](=O)[O-]",
        "output": "564"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].C[N+](=O)[O-].Cc1coc2cccc(C=O)c12.[NH4+]>>Cc1coc2cccc(C=C[N+](=O)[O-])c12",
        "output": "282"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CCCCl.CCc1ccc2oc(Cc3ccccc3)c(S(=O)(=O)c3ccc(O)cc3)c2c1>>CCc1ccc2oc(Cc3ccccc3)c(S(=O)(=O)c3ccc(OCCCN(CC)CC)cc3)c2c1",
        "output": "74"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)OCCC(C)O.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O>>CC(=O)OCCC(C)OS(=O)(=O)c1ccc(C)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=Cc1ccc(C(=O)O)cc1.CN(C)C=O.Cc1ccccc1.O=S(Cl)Cl>>C=Cc1ccc(C(=O)Cl)cc1",
        "output": "3"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCCC/C=C\\CCCCCCCC(=O)Cl.CCCCCCCCCCC(CO)NC(C)=O.CCN(CC)CC.ClCCl>>CCCCCCCCC=CCCCCCCCC(=O)OCC(CCCCCCCCCC)NC(C)=O",
        "output": "126"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.Cl.Nc1ccc2c(ccn2-c2ccc(NC(=O)N(O)c3ccc(Cl)c(C(F)(F)F)c3)cc2)c1>>CC(=O)Nc1ccc2c(ccn2-c2ccc(NC(=O)N(O)c3ccc(Cl)c(C(F)(F)F)c3)cc2)c1",
        "output": "6"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)c1cnc(Cl)c(Cl)c1.N>>CC(=O)c1cnc(N)c(Cl)c1",
        "output": "388"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.C[C@H](N)C(C)(C)C.C[Si](C)(C)CCOCn1cc(C(=O)O)c2nc(Br)cnc21.Cl.ClCCl>>C[C@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Br)nc12)C(C)(C)C",
        "output": "737"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.COc1nc(C(F)(F)F)c(Br)c(CO)c1Br.[H-].[Na+]>>COc1nc(C(F)(F)F)c(Br)c(CO[Si](C)(C)C(C)(C)C)c1Br",
        "output": "193"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "N#Cc1c(N2CCNCC2)cccc1C(F)(F)F.O=C(O)CCOc1cccc(F)c1>>N#Cc1c(N2CCN(C(=O)CCOc3cccc(F)c3)CC2)cccc1C(F)(F)F",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)CCc1ccc(OCCc2nc(-c3ccc(-c4ccccn4)cc3)oc2C)cc1C.Cl.[Na+].[OH-]>>Cc1cc(OCCc2nc(-c3ccc(-c4ccccn4)cc3)oc2C)ccc1CCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cccc(-c2cc(C)c3nc(C)[nH]c3c2)c1.Clc1cc(-c2ccccc2)ccc1CBr>>CCOC(=O)c1cccc(-c2cc(C)c3nc(C)n(Cc4ccc(-c5ccccc5)cc4Cl)c3c2)c1",
        "output": "593"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.N#Cc1ccc(F)cc1.NO>>N=C(NO)c1ccc(F)cc1",
        "output": "854"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.COc1ccc(CCCC(=O)O)cc1.ClCCCl.ClCCl.N[C@@H](CN1CCOCC1)[C@@H](O)c1ccccc1>>COc1ccc(CCCC(=O)N[C@@H](CN2CCOCC2)[C@@H](O)c2ccccc2)cc1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC(C)(C)OC(=O)N[C@H](CNC(=O)Oc1ccc([N+](=O)[O-])cc1)CC1CCCCC1.CCN(C(C)C)C(C)C.CCOCC.COCCCC[C@@](O)(c1cccc(Cl)c1)[C@@H]1CCCNC1.ClCCl>>COCCCC[C@@](O)(c1cccc(Cl)c1)[C@@H]1CCCN(C(=O)NC[C@H](CC2CCCCC2)NC(=O)OC(C)(C)C)C1",
        "output": "770"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.COc1cccc(Nc2ncc3cc(-c4nccs4)c(OC4CCNCC4)cc3n2)c1.[Na+]>>COc1cccc(Nc2ncc3cc(-c4nccs4)c(OC4CCN(C)CC4)cc3n2)c1",
        "output": "217"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Brc1ccc2[nH]c3ccccc3c2c1.C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1>>CC(C)(C)OC(=O)n1c2ccccc2c2cc(Br)ccc21",
        "output": "748"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)Oc1ccc(Cl)cc1-c1c(CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c(=O)[nH]c2ccc(C(F)(F)F)cc12.CC(C)=O.CCOC(C)=O.CI.O=C([O-])[O-].[K+].[K+]>>CC(=O)Oc1ccc(Cl)cc1-c1c(CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c(=O)n(C)c2ccc(C(F)(F)F)cc12",
        "output": "191"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CI.C[C@@]1(O)[C@H](OCc2ccc(Cl)cc2Cl)[C@@H](COCc2ccc(Cl)cc2Cl)O[C@H]1n1ccc2c(Cl)ncnc21.ClCCl.[Cl-].[H-].[NH4+].[Na+]>>CO[C@]1(C)[C@H](OCc2ccc(Cl)cc2Cl)[C@@H](COCc2ccc(Cl)cc2Cl)O[C@H]1n1ccc2c(Cl)ncnc21",
        "output": "140"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=S(=O)(O)O.O=[N+]([O-])O.OC(c1ccccc1)(C(F)(F)F)C(F)(F)F>>O=[N+]([O-])c1cccc(C(O)(C(F)(F)F)C(F)(F)F)c1",
        "output": "21"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COc1cc(I)c(Cl)cc1C(=O)O.Cl.O=C([O-])[O-].OB(O)c1ccccc1C(F)(F)F.[K+].[K+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc(-c2ccccc2C(F)(F)F)c(Cl)cc1C(=O)O",
        "output": "855"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC(=O)c1cc(Cl)ccc1N.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>CCCCCC(=O)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C)cc1",
        "output": "68"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O=Cc1ccc(O)c(Br)c1.OCCO>>Oc1ccc(C2OCCO2)cc1Br",
        "output": "117"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)O.CC(C)(C)[O-].COc1ccc(CO)cc1.Cc1ccccc1.ClCCl.O=C(c1ccc(Oc2nccnc2-c2cccnc2F)cc1)c1nc2ccccc2[nH]1.[K+]>>COc1ccc(COc2ncccc2-c2nccnc2Oc2ccc(C(=O)c3nc4ccccc4[nH]3)cc2)cc1",
        "output": "541"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)[C@](C)(NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(Cl)cc(Cl)cc1Cl)C1CCCCC1.Cl.O.O.[Li+].[OH-]>>C[C@](NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(Cl)cc(Cl)cc1Cl)(C(=O)O)C1CCCCC1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)c1ccc(O)cc1.CO.O=C(NCC(=O)N1CCN(C(=O)c2cc(F)ccc2C(F)(F)F)CC1)c1cc(-c2ccc(OCc3ccccc3)cc2)[nH]n1.[Pd]>>O=C(NCC(=O)N1CCN(C(=O)c2cc(F)ccc2C(F)(F)F)CC1)c1cc(-c2ccc(O)cc2)[nH]n1",
        "output": "23"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)N(C)C.CCOC(C)=O.NC(=O)C1CCNCC1.O=C([O-])[O-].O=Cc1ccc(Cl)cc1F.[K+].[K+]>>NC(=O)C1CCN(c2cc(Cl)ccc2C=O)CC1",
        "output": "868"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C[Al+]CC(C)C.CCCCCC.COC(=O)CC(c1ccccc1)n1cc(-c2ncnc3c2ccn3COCC[Si](C)(C)C)cn1.ClCCl.[H-]>>C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C(CCO)c4ccccc4)c3)ncnc21",
        "output": "343"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1ccc(C(F)(F)C(F)(F)c2ccccc2)cc1.CCO.Cl.NO.c1ccncc1>>CC(=NO)c1ccc(C(F)(F)C(F)(F)c2ccccc2)cc1",
        "output": "212"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(NC2CCN([C@H](C)CCN)CC2)cc1.Cc1ncnc(C)c1C(=O)O>>COc1ccc(NC2CCN([C@H](C)CCNC(=O)c3c(C)ncnc3C)CC2)cc1",
        "output": "737"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNCC1.O=C(O)c1ccc2c(c1)OC(c1cccc(Cl)c1)(c1cccc(Cl)c1)O2>>O=C(c1ccc2c(c1)OC(c1cccc(Cl)c1)(c1cccc(Cl)c1)O2)N1CCCCC1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)O.CCOc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1nc(Cl)ncc1Cl.COc1cc(N2CCN(C(C)=O)CC2)ccc1N.Cl>>CCOc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1nc(Nc2ccc(N3CCN(C(C)=O)CC3)cc2OC)ncc1Cl",
        "output": "808"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COc1ccccc1Br.O=C([O-])O.O=C1CCC2(CC1)OCCO2.[Li]CCCC.[Na+]>>COc1ccccc1C1(O)CCC2(CC1)OCCO2",
        "output": "321"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)C1CCCCC1N.O=C(O)c1cccc(C2CCCCC2)n1>>COC(=O)C1CCCCC1NC(=O)c1cccc(C2CCCCC2)n1",
        "output": "137"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1nc(C(C)(N)C2CC2)no1.O=C(O)c1cnc(C2CC2)c(OCC2CC2)n1>>Cc1nc(C(C)(NC(=O)c2cnc(C3CC3)c(OCC3CC3)n2)C2CC2)no1",
        "output": "697"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=Cc1ccc(Oc2cc(N)ccc2[N+](=O)[O-])cc1.CCCCCC.CCO.CCOC(C)=O.Cl.Cl[Sn]Cl.[K+].[OH-]>>C=Cc1ccc(Oc2cc(N)ccc2N)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOCC.Nc1ccccc1.O.O=C(Cl)Cc1ccc(Cl)cc1Cl>>O=C(Cc1ccc(Cl)cc1Cl)Nc1ccccc1",
        "output": "9"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CCOc1ccc(Br)c(F)c1OCC.CN(C)C=O.N.N#C[Cu]>>CCOc1ccc(C#N)c(F)c1OCC",
        "output": "531"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(Cl)OC(=O)Cl.ClCCCl.N#CC(C#N)=C1N(CCCN2CCOCC2)CCN1C1CCN(Cc2ccccc2)CC1>>N#CC(C#N)=C1N(CCCN2CCOCC2)CCN1C1CCNCC1",
        "output": "84"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCC.NN.O.O.O=c1[nH]c2ccc(Cl)nc2cc1-c1ccccc1.c1ccncc1>>NNc1ccc2[nH]c(=O)c(-c3ccccc3)cc2n1",
        "output": "417"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](Nc2c(C(=O)C3CC3)cnc3ccc(-c4cc(F)c(O)c(Cl)c4)cc23)CC1.O=C(O)C(F)(F)F>>N[C@@H]1CC[C@@H](Nc2c(C(=O)C3CC3)cnc3ccc(-c4cc(F)c(O)c(Cl)c4)cc23)CC1",
        "output": "538"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCCO.N[C@@H](Cc1ccc(O)c([N+](=O)[O-])c1)C(=O)O.[Na+].[OH-]>>CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)c([N+](=O)[O-])c1)C(=O)O",
        "output": "626"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C)=O.COC(=O)CBr.O=C([O-])[O-].Oc1cccc(C(F)(F)F)c1.[K+].[K+]>>COC(=O)COc1cccc(C(F)(F)F)c1",
        "output": "557"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cc1ccc(C(=O)O)c(N)n1.F[P-](F)(F)(F)(F)F.NCc1cccc(Oc2ccc(Cl)cc2)c1>>Cc1ccc(C(=O)NCc2cccc(Oc3ccc(Cl)cc3)c2)c(N)n1",
        "output": "790"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)c1ccccc1-c1ccc(CBr)cc1.CCCc1nc2c(C)cc(-c3nc4ccc(N(C)CCO)cc4n3C)cc2[nH]1.CN(C)C=O.O=C([O-])[O-].[H-].[K+].[K+].[Na+]>>CCCc1nc2c(C)cc(-c3nc4ccc(N(C)CCO)cc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1",
        "output": "658"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.CSc1nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c2c(=O)n1C.ClCCl.O.O=S([O-])OO.[K+]>>Cn1c(S(C)(=O)=O)nc2oc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)c2c1=O",
        "output": "840"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=C(c1cccc(O)c1)c1ccc(OC)c(C)c1.CN(C)C=O.COc1cccc(CBr)c1.O=C([O-])[O-].[Cs+].[Cs+]>>C=C(c1cccc(OCc2cccc(OC)c2)c1)c1ccc(OC)c(C)c1",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-].CO.[H][H].[Ni]>>CCCCNc1ccc(C(=O)O)cc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1cc2cc(N)ccc2[nH]1.Cc1ccc(C)n1-c1ncc(-c2cc3nccc(Cl)c3s2)cn1>>Cc1cc2cc(Nc3ccnc4cc(-c5cnc(-n6c(C)ccc6C)nc5)sc34)ccc2[nH]1",
        "output": "927"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)n1ncc2c(Cl)cc(-c3cccc(OCC4CO4)c3)nc21.CN.CO>>CNCC(O)COc1cccc(-c2cc(Cl)c3cnn(C(C)C)c3n2)c1",
        "output": "16"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)CBr.CS(C)=O.O=C([O-])[O-].O=c1c(Cc2cccnc2)cn2c3ccc(Br)cc3c3cc(O)cc1c32.[K+].[K+]>>CC(C)(C)OC(=O)COc1cc2c(=O)c(Cc3cccnc3)cn3c4ccc(Br)cc4c(c1)c23",
        "output": "393"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)CCCCCCCN.Cl.Cl.O.O=C(O)C=C1c2ccccc2-c2ccccc21.Oc1cccc2[nH]nnc12.[Cl-].[Na+]>>COC(=O)CCCCCCCNC(=O)C=C1c2ccccc2-c2ccccc21",
        "output": "549"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CCNCC1.NC(=O)c1cc(-c2ccccc2)cc2c(C3CCN(S(=O)(=O)CCCCl)CC3)c[nH]c12.NS(N)(=O)=O.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CN1CCN(CCCS(=O)(=O)N2CCC(c3c[nH]c4c(C(N)=O)cc(-c5ccccc5)cc34)CC2)CC1",
        "output": "138"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)c1ccc(C(F)(F)F)c(C(C)C)c1.Cl.[BH4-].[Li+]>>CC(C)c1cc(CO)ccc1C(F)(F)F",
        "output": "444"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CN1CCOCC1.COc1cc(Nc2nc(-c3cccc(N)c3)nn3c(C)nc(C)c23)cc(OC)c1OC.ClCCCl.On1nnc2ccccc21>>COc1cc(Nc2nc(-c3cccc(NC(C)=O)c3)nn3c(C)nc(C)c23)cc(OC)c1OC",
        "output": "365"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1cn(-c2ncnc3c2ccn3C)c2ccccc12.O.O.[Li+].[OH-]>>Cn1ccc2c(-n3cc(C(=O)O)c4ccccc43)ncnc21",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.COc1ccc(N)c(N(C)C(=O)OC(C)(C)C)c1.Cl.ClCCl.O.O=C(O)COc1ccc(CC2SC(=O)NC2=O)cc1.O=C([O-])O.O=S(Cl)Cl.[Na+]>>COc1ccc(NC(=O)COc2ccc(CC3SC(=O)NC3=O)cc2)c(N(C)C(=O)OC(C)(C)C)c1",
        "output": "646"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C(OC2CCNCC2)c2ccccc2)cc1.O=[N+]([O-])c1ccccc1OCCCCl>>COc1ccc(C(OC2CCN(CCCOc3ccccc3[N+](=O)[O-])CC2)c2ccccc2)cc1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.Nc1ncnc(Cl)c1F.O=C(Cl)c1c(Cl)cccc1Cl.[H-].[Na+]>>O=C(Nc1ncnc(Cl)c1F)c1c(Cl)cccc1Cl",
        "output": "463"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.NN.O.O=C(Nc1ccc(C2CCCCC2)cc1)c1ccc(Cl)nc1>>NNc1ccc(C(=O)Nc2ccc(C3CCCCC3)cc2)cn1",
        "output": "417"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)n1c(=O)n(-c2ccc(OCc3ccccc3)cc2)c2ncc(Cl)cc21.CCOC(C)=O.[Pd]>>CC(C)n1c(=O)n(-c2ccc(O)cc2)c2ncc(Cl)cc21",
        "output": "698"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN.O=C(Nc1nc(-c2c(F)c(F)c(F)c(F)c2F)c(C(=O)O)s1)c1cc(Br)ccc1O>>CCNC(=O)c1sc(NC(=O)c2cc(Br)ccc2O)nc1-c1c(F)c(F)c(F)c(F)c1F",
        "output": "534"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN1CCCC1CCN.ClCCl.O=Cc1ccc2ccccc2n1.[Na]>>CN1CCCC1CCNCc1ccc2ccccc2n1",
        "output": "775"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CN1CCOCC1.C[C@H](N)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1.Cl.ClC(Cl)Cl.O=C(O)[C@@H]1CCCN1>>C[C@H](NC(=O)[C@@H]1CCCN1)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1",
        "output": "131"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COCC1(C)CCN(c2cccc(-c3cnc4c(n3)c(C(=O)C(C)(C)C)cn4COCC[Si](C)(C)C)c2)C1.ClCCl>>COCC1(C)CCN(c2cccc(-c3cnc4[nH]cc(C(=O)C(C)(C)C)c4n3)c2)C1",
        "output": "981"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(CC(CP(=O)(O)Cc2ccccc2)C(=O)O)cn1.CCOC(C)=O.Cl>>Nc1ccc(CC(CP(=O)(O)Cc2ccccc2)C(=O)O)cn1",
        "output": "885"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COc1cccc(OC)c1C(=O)Cl.Cl.ClCCl.Clc1ccc2nc(NCC3CCNC3)oc2c1>>COc1cccc(OC)c1C(=O)N1CCC(CNc2nc3ccc(Cl)cc3o2)C1",
        "output": "201"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCN.CCOC(C)=O.COc1cccc2c(-c3ccnc(F)c3)c(-c3ccc(F)cc3)nn12>>CCCCNc1cc(-c2c(-c3ccc(F)cc3)nn3c(OC)cccc23)ccn1",
        "output": "810"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O=c1c(-c2ccccc2)c(O)c2c(-c3ccccc3)ncnc2n1OCc1ccccc1.[C].[H][H].[OH-].[OH-].[Pd+2]>>O=c1c(-c2ccccc2)c(O)c2c(-c3ccccc3)ncnc2n1O",
        "output": "630"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)C[Al+]CC(C)C.COC(=O)c1cnc(Br)cc1I.ClCCl.[H-]>>OCc1cnc(Br)cc1I",
        "output": "522"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN1CCNCC1.ClCCl.O=C(Cl)CCl>>CN1CCN(C(=O)CCl)CC1",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COc1ccc(-c2cc(C(=O)O)nn2-c2ccc(C)nc2)nc1.Cl.ClC(Cl)Cl.O.On1nnc2ccccc21>>COc1ccc(-c2cc(C(=O)N3CCOCC3)nn2-c2ccc(C)nc2)nc1",
        "output": "663"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)O)cn1.NC1CCOCC1>>Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)NC2CCOCC2)cn1",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)C(=O)Cl.CCOC(C)=O.CN(C)C=O.ClCCl.NCCN1CCC(CNC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1.O=C([O-])O.[Na+]>>CC(C)(C)C(=O)NCCN1CCC(CNC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1",
        "output": "45"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1ccc(C2(CN)CCCC2)cc1OC.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(Cc2ccccc2)cc1>>COc1ccc(C2(CNC(=O)c3ccc(Cc4ccccc4)cc3)CCCC2)cc1OC",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)c(OCCCBr)c1.[K+].[K+].c1ccc(N2CCNCC2)cc1>>O=[N+]([O-])c1ccc(Cl)c(OCCCN2CCN(c3ccccc3)CC2)c1",
        "output": "73"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COc1cc(F)c(-c2ccccc2)cc1C(=O)O.Cl.ClCCl.NCc1cccc([N+](=O)[O-])c1.O=C(Cl)C(=O)Cl>>COc1cc(F)c(-c2ccccc2)cc1C(=O)NCc1cccc([N+](=O)[O-])c1",
        "output": "753"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1nc(-c2ccc(Cl)s2)cs1.O=S(=O)(Cl)c1c(Cl)cc(Cl)cc1Cl>>O=S(=O)(Nc1nc(-c2ccc(Cl)s2)cs1)c1c(Cl)cc(Cl)cc1Cl",
        "output": "637"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.O=C(CBr)c1ccc(Cl)cc1.O=C(O)CC(CN1CCCC(c2cccc(C(F)(F)F)c2)C1)C(F)(F)F>>O=C(CC(CN1CCCC(c2cccc(C(F)(F)F)c2)C1)C(F)(F)F)OCC(=O)c1ccc(Cl)cc1",
        "output": "523"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCC(=O)Cl.CCN(CC)CC.OC1(Cc2ccc3c(c2)CCN(C2CCC2)CC3)CCNCC1>>CCC(=O)N1CCC(O)(Cc2ccc3c(c2)CCN(C2CCC2)CC3)CC1",
        "output": "125"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.Cc1cc(Br)cc(C)c1Oc1ccnc(Cl)c1.Nc1ccc(Br)cc1>>Cc1cc(Br)cc(C)c1Oc1ccnc(Nc2ccc(Br)cc2)c1",
        "output": "434"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.O=C(O)CCc1cccc([N+](=O)[O-])c1>>O=[N+]([O-])c1cccc(CCCO)c1",
        "output": "231"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCc1cn(Cc2ccc(OCc3nc(-c4ccco4)oc3C)c(OC)c2)nc1OCC.Cl.[Na+].[OH-]>>CCOc1nn(Cc2ccc(OCc3nc(-c4ccco4)oc3C)c(OC)c2)cc1CCC(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.CCOc1nn(-c2cc(C(F)(F)F)ccn2)cc1CCCO.COC(=O)Cc1ccccc1O.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CCOc1nn(-c2cc(C(F)(F)F)ccn2)cc1CCCOc1ccccc1CC(=O)O",
        "output": "928"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1ccc([N+](=O)[O-])c(NCCCN2CCCCC2)n1.CO.[Li+].[OH-]>>O=C(O)c1ccc([N+](=O)[O-])c(NCCCN2CCCCC2)n1",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)CCc1cn(Cc2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)nc1OCc1ccccc1.Cl.[Na+].[OH-]>>Cc1oc(-c2ccccc2)nc1COc1ccc(Cn2cc(CCC(=O)O)c(OCc3ccccc3)n2)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN.CCN(C(C)C)C(C)C.CN(C)C=O.Cc1ccc(C(=O)O)cc1-n1cnc2ccc(OCCCl)cc2c1=O.ClCCl.O=C(Cl)C(=O)Cl>>CCNC(=O)c1ccc(C)c(-n2cnc3ccc(OCCCl)cc3c2=O)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.COc1cc2c(Cl)nccc2cc1C(=O)O.F[B-](F)(F)F>>COc1cc2c(Cl)nccc2cc1C(=O)N1CCCC1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)N1CCN(c2ccc(Nc3ccc(Cl)n4ccnc34)cc2)CC1.CCO.CCOC(C)=O.COC(=O)c1ccc(Nc2ccc(-c3ccc4c(c3)CNC4=O)n3ccnc23)cc1.O.[Li+].[OH-]>>O=C(O)c1ccc(Nc2ccc(-c3ccc4c(c3)CNC4=O)n3ccnc23)cc1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CN(C)C=O.NNc1ccc(Cl)nn1.O=C(Cl)Cc1c(F)cc2ncccc2c1F>>O=C(Cc1c(F)cc2ncccc2c1F)NNc1ccc(Cl)nn1",
        "output": "450"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CCC(C)=O.COCCCl.O=C([O-])[O-].O=C(c1ccccc1)N1CCN(Cc2ccc(OC3CCNCC3)cc2)CC1.[I-].[K+].[K+].[K+]>>COCCN1CCC(Oc2ccc(CN3CCN(C(=O)c4ccccc4)CC3)cc2)CC1",
        "output": "138"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.Cc1cc(OCCCOC2CCCCO2)cc(C)c1[SiH](C(C)C)C(C)C.Cc1ccc(S(=O)(=O)[O-])cc1.O=C([O-])O.[Na+].c1cc[nH+]cc1>>Cc1cc(OCCCO)cc(C)c1[SiH](C(C)C)C(C)C",
        "output": "543"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)Nc1cn(-c2cccnc2)nc1Cl.CCOC(C)=O.CCOCC.Cl.FB(F)F.O.O=C([O-])O.[BH4-].[Na+].[Na+]>>CCNc1cn(-c2cccnc2)nc1Cl",
        "output": "112"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCBr.CC#N.CS(=O)(=O)c1cccc(C2CCNCC2)c1F.Cl.O=C([O-])[O-].[K+].[K+]>>C=CCN1CCC(c2cccc(S(C)(=O)=O)c2F)CC1",
        "output": "252"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)CC1C2CC3CC(C2)CC1C3.[Na+].[OH-]>>O=C(O)CC1C2CC3CC(C2)CC1C3",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Cl.O=C(O)C12CCN(CC1)CC2.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCC12CCN(CC1)CC2",
        "output": "231"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(C(C)C)C(C)C.CN(C)C=O.Cc1nnc([C@@H]2CCCN2)o1.Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)O)n1>>Cc1nnn(Cc2cc(Cl)ccc2/C=C/C(=O)N2CCC[C@H]2c2nnc(C)o2)n1",
        "output": "811"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNC1.N#Cc1ccc(C(F)(F)F)nc1Cl>>N#Cc1ccc(C(F)(F)F)nc1N1CCCC1",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccccc1.O=C(O)C1CCC(F)(F)CC1.O=S(Cl)Cl>>O=C(Cl)C1CCC(F)(F)CC1",
        "output": "53"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.OCCCCCCCC=CCCc1ccccc1.[Pd]>>OCCCCCCCCCCCc1ccccc1",
        "output": "143"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCc1ccc(OCCCC(C)Oc2ccc(CCC(=O)OC)c(C)c2)c(C(=O)c2ccccc2)c1.CO.Cl.O.[Na+].[OH-]>>CCc1ccc(OCCCC(C)Oc2ccc(CCC(=O)O)c(C)c2)c(C(=O)c2ccccc2)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1c(-c2ccc(OCC3CC3)cc2)c2cc(OCC(=O)OC(C)(C)C)ccc2n1Cc1cccc(OC)c1.ClCCl.O=CO>>CCOC(=O)c1c(-c2ccc(OCC3CC3)cc2)c2cc(OCC(=O)O)ccc2n1Cc1cccc(OC)c1",
        "output": "278"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CI.COC(=O)c1ccc2nc(-c3ccccc3)c(N3CCC(C(=O)OC(C)(C)C)CC3)nc2c1.[H-].[Na+]>>CC(C)(C)OC(=O)C1CCN(c2nc3cc(C(=O)O)ccc3nc2-c2ccccc2)CC1",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCI.CN(C)C=O.O.O=C([O-])[O-].O=Cc1ccsc1C(=O)O.[K+].[K+]>>CCOC(=O)c1sccc1C=O",
        "output": "196"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cn(Cc2ccccc2)c(=O)n(CC2(COS(C)(=O)=O)CC2)c1=O.FC(F)(F)COc1ccccc1N1CCNCC1>>Cc1cn(Cc2ccccc2)c(=O)n(CC2(CN3CCN(c4ccccc4OCC(F)(F)F)CC3)CC2)c1=O",
        "output": "496"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCCCC1.CC1(C)OB(c2ccc3c(c2)CC(=O)N3)OC1(C)C.CCOC(C)=O.Clc1nc(NCC(c2ccccc2)c2ccccc2)c2ccccc2n1.c1ccc(C(Nc2nc(-c3cc4ccccc4s3)nc3ccccc23)c2ccccc2)cc1>>O=C1Cc2cc(-c3nc(NCC(c4ccccc4)c4ccccc4)c4ccccc4n3)ccc2N1",
        "output": "974"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCN1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.O=Cc1ccc(C(=O)O)cc1.On1nnc2cccnc21>>O=Cc1ccc(C(=O)N2CCOCC2)cc1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCCc1nnc(C(=O)NC2CCNCC2)cc1-c1ccc(OCc2ccccc2)cc1.Cl.Cl.ClCCl.[Na+]>>CCCCc1nnc(C(=O)NC2CCN(C)CC2)cc1-c1ccc(OCc2ccccc2)cc1",
        "output": "217"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCCCC(C)C(=O)O.ClCCl.Oc1ccccc1.[Al+3].[Cl-].[Cl-].[Cl-]>>CCCCCCCCC(C)C(=O)c1ccc(O)cc1",
        "output": "435"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)CCN[C@@H]1C(N)=O.CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.Cl.O.O=CN(C[C@@H](CC1CCCC1)C(=O)O)OCc1ccccc1.On1nnc2cccnc21>>CC1(C)CCN(C(=O)[C@H](CC2CCCC2)CN(C=O)OCc2ccccc2)[C@@H]1C(N)=O",
        "output": "297"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Cl.Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CCl)sc21.O[C@H](c1ccccc1)[C@H]1COCCN1>>Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN3CCOC[C@@H]3[C@H](O)c3ccccc3)sc21",
        "output": "639"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(S(=O)(=O)Cl)cc1.Nc1ccc(N2CCC3(CC2)OCCO3)cc1>>COc1ccc(S(=O)(=O)Nc2ccc(N3CCC4(CC3)OCCO4)cc2)cc1",
        "output": "68"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1ccc(NC(=O)C(CC(C)F)n2cc(OC)c(-c3cc(Cl)ccc3C#N)cc2=O)cc1.[Li+].[OH-]>>COc1cn(C(CC(C)F)C(=O)Nc2ccc(C(=O)O)cc2)c(=O)cc1-c1cc(Cl)ccc1C#N",
        "output": "5"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COC(=O)Cc1cccc(S(=O)(=O)C2CCCC2)c1.ClCCl.O.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>O=S(=O)(c1cccc(CCO)c1)C1CCCC1",
        "output": "343"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.O=C(Cl)CCl.O=C([O-])[O-].O=[N+]([O-])c1ccc(N2CCCNCC2)cc1.[K+].[K+]>>O=C(CCl)N1CCCN(c2ccc([N+](=O)[O-])cc2)CC1",
        "output": "125"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OCc1ccn(-c2cc3c(=O)n(NS(C)(=O)=O)c(=O)[nH]c3cc2C(F)(F)F)c1.CO.O=C([O-])[O-].O=P([O-])([O-])[O-].[K+].[K+]>>CS(=O)(=O)Nn1c(=O)[nH]c2cc(C(F)(F)F)c(-n3ccc(CO)c3)cc2c1=O",
        "output": "348"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cn1nc(-c2c(F)cccc2Cl)nc1-c1ccc(CCl)c(Cl)c1.O.O=C([O-])[O-].Oc1ccc(C(F)(F)F)cc1F.[K+].[K+]>>Cn1nc(-c2c(F)cccc2Cl)nc1-c1ccc(COc2ccc(C(F)(F)F)cc2F)c(Cl)c1",
        "output": "49"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)Cl.Cl.Cl.NCCCCC(=O)O.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)NCCCCC(=O)O",
        "output": "94"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)c1ccccn1.C[C@]12CC[C@H]3[C@@H]([C@@H](O)C=C4C[C@@H](O)CC[C@@]43C)[C@@H]1[C@@H]1C[C@@H]1C2=O.ClCCl.Cl[Si](Cc1ccccc1)(Cc1ccccc1)Cc1ccccc1>>C[C@]12CC[C@H]3[C@@H]([C@@H](O)C=C4C[C@@H](O[Si](Cc5ccccc5)(Cc5ccccc5)Cc5ccccc5)CC[C@@]43C)[C@@H]1[C@@H]1C[C@@H]1C2=O",
        "output": "193"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CN(C)C=O.CNCCOc1cc(C)c(C(C)=O)cc1C(C)C.COc1c(C)c(C)c(O)c(C)c1CCl>>COc1c(C)c(C)c(O)c(C)c1CN(C)CCOc1cc(C)c(C(C)=O)cc1C(C)C",
        "output": "156"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)O.CC(=O)[O-].Nc1cccc2ccc(O)cc12.O=C(Cl)CCl.[Na+]>>O=C(CCl)Nc1cccc2ccc(O)cc12",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc(N)ccc1-n1cnc(C)c1.Cc1nc(Cl)cc(C2(c3ccc(Cl)cc3)CCC2)n1>>COc1cc(Nc2cc(C3(c4ccc(Cl)cc4)CCC3)nc(C)n2)ccc1-n1cnc(C)c1",
        "output": "161"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CI.CN(C)C=O.Cc1cc(-c2cc[nH]c(=O)n2)cc(C)c1I.O=C([O-])[O-].[K+].[K+]>>Cc1cc(-c2ccn(C)c(=O)n2)cc(C)c1I",
        "output": "570"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCOc1ccc2c(c1)C(c1ccc(OC)cc1OCOC)C(CC#N)C2c1ccc2c(c1)OCO2.CCO.Cl>>CCCOc1ccc2c(c1)C(c1ccc(OC)cc1O)C(CC#N)C2c1ccc2c(c1)OCO2",
        "output": "755"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Cc1cc(Br)ccc1C(=O)O.O.O=C([O-])[O-].[K+].[K+]>>Cc1cc(Br)ccc1CO",
        "output": "72"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CS(C)=O.Cc1cccnc1F.Nc1ccc(O)cc1.O=C([O-])[O-].[Cs+].[Cs+]>>Cc1cccnc1Oc1ccc(N)cc1",
        "output": "727"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)CC(=O)c1cccc(-n2nncc2COC2CCCCO2)c1.CCCN(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1Cl>>CCCN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-n3nncc3COC3CCCCO3)c2)cc1Cl",
        "output": "929"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COC(CNC(=O)C(CSC(C)=O)CC(C)C)OC>>COC(CNC(=O)C(CS)CC(C)C)OC",
        "output": "90"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)O[K].CC(C)(C)n1cc(C(=O)O)c(=O)c2cc(F)c(Cl)cc21.CS(C)=O.O.OCCOCCO>>CC(C)(C)n1cc(C(=O)O)c(=O)c2cc(OCCOCCO)c(Cl)cc21",
        "output": "485"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.NCCO.O=C(O)C=Cc1ccccc1I.O=S(Cl)Cl>>O=C(/C=C/c1ccccc1I)NCCO",
        "output": "549"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=O.CO.C[O-].C[O-].O=S(=O)(O)O.Oc1cccc(Cl)c1-c1ccccc1C(F)(F)F.[Mg+2]>>O=Cc1ccc(Cl)c(-c2ccccc2C(F)(F)F)c1O",
        "output": "451"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CCc1ccc(N)cc1.C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC>>C#CCc1ccc(NC(=O)OC(C)(C)C)cc1",
        "output": "735"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(-c2ccc(CN3CCN(C(=O)OC(C)(C)C)CC3)c(C)c2)cc(C)n1.ClCCl.O=C(O)C(F)(F)F>>Cc1cc(-c2ccc(CN3CCNCC3)c(C)c2)cc(C)n1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.FC(F)(F)c1ccc(Cl)nc1.O.O=C([O-])[O-].Oc1ccc(O)cc1.[K+].[K+]>>Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1",
        "output": "516"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(Cl)c(-n2c(=O)[nH]c3c(CO)ncnc32)cc1OCc1c(OC)ccc(F)c1F.ClCCl.[Mn+4].[O-2].[O-2]>>COc1cc(Cl)c(-n2c(=O)[nH]c3c(C=O)ncnc32)cc1OCc1c(OC)ccc(F)c1F",
        "output": "287"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCNCC1.CC(=O)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C(=O)O>>CC(=O)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C(=O)N1CCCCC1",
        "output": "517"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCCC(Nc1ccc(-n2cc(-c3ccccc3)cn2)nc1)c1ccc(C(=O)NCCC(=O)OC)cc1.CO.[Na+].[OH-]>>CCCC(Nc1ccc(-n2cc(-c3ccccc3)cn2)nc1)c1ccc(C(=O)NCCC(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CO.O.O=[N+]([O-])c1ccc(OCc2ccccc2)cc1Sc1ccc(O)cc1.[Cl-].[Fe].[NH4+]>>Nc1ccc(OCc2ccccc2)cc1Sc1ccc(O)cc1",
        "output": "202"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C[C@@H](C(=O)NN(CC(C)C)C(=O)Cn1ccnc1)[C@H](CCNC(=O)c1ccccc1)C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F>>CC(C)C[C@@H](C(=O)NN(CC(C)C)C(=O)Cn1ccnc1)[C@H](CCNC(=O)c1ccccc1)C(=O)O",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.CNC.NC(=O)c1sc(-n2cnc3ccc(OCCCl)cc32)nc1-c1cccc(Cl)c1.O=C([O-])[O-].[I-].[K+].[K+].[K+]>>CN(C)CCOc1ccc2ncn(-c3nc(-c4cccc(Cl)c4)c(C(N)=O)s3)c2c1",
        "output": "138"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc(O)nc(/C=C/c2cccc([N+](=O)[O-])c2)n1.O=P(Cl)(Cl)Cl>>Cc1cc(Cl)nc(/C=C/c2cccc([N+](=O)[O-])c2)n1",
        "output": "25"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2C=O)c1.N[C@H]1CCc2ccccc21>>COC(=O)Cc1ccc(OC)c(-c2ccc(C(F)(F)F)cc2CN[C@H]2CCc3ccccc32)c1",
        "output": "683"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CCOC(=O)Cc1ccc(NC(=O)c2cc(OCc3cccc(Cl)c3)ccc2Cl)c(Cl)c1.Cl.O>>O=C(O)Cc1ccc(NC(=O)c2cc(OCc3cccc(Cl)c3)ccc2Cl)c(Cl)c1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCn1c(=O)c(NC(=O)Nc2c(C(C)C)cccc2C(C)C)c(-c2cccc(OCCCOCc3ccccc3)c2)c2cccnc21.CO.O=C[O-].[C].[NH4+].[Pd]>>CCCCn1c(=O)c(NC(=O)Nc2c(C(C)C)cccc2C(C)C)c(-c2cccc(OCCCO)c2)c2cccnc21",
        "output": "178"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Cl.O=C(O)c1ccc(Cc2ccccc2)cn1>>CCOC(=O)c1ccc(Cc2ccccc2)cn1",
        "output": "331"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COC(=O)[C@@H]1CC[C@@H](c2nc(Br)c(-c3ccccc3)o2)CC1.O=C([O-])O.[Na+].[Na+].[OH-]>>O=C(O)[C@@H]1CC[C@@H](c2nc(Br)c(-c3ccccc3)o2)CC1",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCCNCCCC.ClCCCOc1c(Cl)cc(-c2csc(-c3ccccc3)n2)cc1Cl.NC(=S)c1ccccc1>>CCCCN(CCCC)CCCOc1c(Cl)cc(-c2csc(-c3ccccc3)n2)cc1Cl",
        "output": "138"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCc1cc(C(=O)OC)ccc1O.CO.[C].[Pd]>>CCCc1cc(C(=O)OC)ccc1O",
        "output": "116"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CCOC(=O)c1c[nH]c2c(Cl)ccc(C(F)(F)F)c2c1=O.O.[Na+].[OH-]>>O=C(O)c1c[nH]c2c(Cl)ccc(C(F)(F)F)c2c1=O",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NC(Cc1cc(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)ccc1[N+](=O)[O-])C(=O)OC(C)(C)C.CC(C)O.[Pd]>>CC(C)(C)OC(=O)NC(Cc1cc(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)ccc1N)C(=O)OC(C)(C)C",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Cl.CCN(CC)CC.COC(=O)c1ccc2c(c1)OC[C@@H](C(C)C)NC2.ClCCl>>COC(=O)c1ccc2c(c1)OC[C@@H](C(C)C)N(C(C)=O)C2",
        "output": "240"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)Cc1ccccc1CCc1nc(Nc2ccc(C3CN(C(=O)OC(C)(C)C)CCO3)cc2)ncc1C(F)(F)F.O.O.[Li+].[OH-]>>CC(C)(C)OC(=O)N1CCOC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(=O)O)n3)cc2)C1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CCc1c(O)ccc2c(-c3ccccc3)c(C)oc12.CCO.[Pd]>>CCCc1c(O)ccc2c(-c3ccccc3)c(C)oc12",
        "output": "116"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)C1Cc2cc(N)ccc2O1.Fc1cnc(Cl)nc1Nc1ccc(OC(F)(F)F)c(Cl)c1>>COC(=O)C1Cc2cc(Nc3ncc(F)c(Nc4ccc(OC(F)(F)F)c(Cl)c4)n3)ccc2O1",
        "output": "907"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCl.Nc1ccccc1[N+](=O)[O-].O.O=C(O)CCN1C(=O)CSC1=S.O=S(Cl)Cl>>O=C(CCN1C(=O)CSC1=S)Nc1ccccc1[N+](=O)[O-]",
        "output": "365"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(CC)(c1ccc(O)c(C)c1)c1ccc(C#CC(O)C(C)(C)C)c(C)c1.CCOC(C)=O.[H][H].[Pd]>>CCC(CC)(c1ccc(O)c(C)c1)c1ccc(CCC(O)C(C)(C)C)c(C)c1",
        "output": "717"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N(C)C.CCONC(=O)c1ccc(C)c(-n2cnc3ccc(OCCCl)cc3c2=O)c1.CNC(C)C.[I-].[K+]>>CCONC(=O)c1ccc(C)c(-n2cnc3ccc(OCCN(C)C(C)C)cc3c2=O)c1",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.C1CCOC1.CC(C)COC(=O)Cl.CCCNCC.CCOC(C)=O.CN1CCOCC1.Cl.O=C(O)Cc1ccc(O)cc1>>CCCN(CC)C(=O)Cc1ccc(O)cc1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COc1cc(C(=O)O)ccc1O.Cl.ClCc1ccccc1.[Na+].[OH-]>>COc1cc(C(=O)O)ccc1OCc1ccccc1",
        "output": "49"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[O-].CCNC(=O)Nc1nc2cc(-c3cnc(N4CCC(C)(C(=O)OCC)CC4)nc3)cc(C(=O)NCC)c2s1.CS(C)=O.[K+]>>CCNC(=O)Nc1nc2cc(-c3cnc(N4CCC(C)(C(=O)O)CC4)nc3)cc(C(=O)NCC)c2s1",
        "output": "281"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCc1c(OCc2cccc(C(=O)OC)n2)ccc(C(C)=O)c1O.CO.O.[Li+].[OH-]>>CCCc1c(OCc2cccc(C(=O)O)n2)ccc(C(C)=O)c1O",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.ClCCl.Nc1cncc(Br)c1.O=S(=O)(Cl)C1CC1.c1ccncc1>>O=S(=O)(Nc1cncc(Br)c1)C1CC1",
        "output": "812"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CN(C)C=O.Cc1cccc(O)c1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>Cc1cccc(OCc2ccccc2)c1[N+](=O)[O-]",
        "output": "127"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NCC1CC1.O=C(NC(Cc1ccccc1)C(O)C(=O)O)c1cccnc1-n1ccc(-c2ccccc2)n1>>O=C(NC(Cc1ccccc1)C(O)C(=O)NCC1CC1)c1cccnc1-n1ccc(-c2ccccc2)n1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N[C@@H]1CCCC[C@H]1C=O.ClCCl.O.[Na+].[Na+].[OH-].c1ccc(C2CCNCC2)cc1>>CC(C)(C)OC(=O)N[C@@H]1CCCC[C@H]1CN1CCC(c2ccccc2)CC1",
        "output": "484"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CNC1CC1.COCOc1ccc(C(=O)O)nc1Cl>>COCOc1ccc(C(=O)N(C)C2CC2)nc1Cl",
        "output": "605"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCN(C2CCNCC2)CC1.CCN=C=NCCCN(C)C.COc1cc2ncnc(Oc3ccc(OCC(=O)O)cc3)c2cc1OC.Cl.ClC(Cl)Cl.O.O=C([O-])O.On1nnc2ccccc21.[Na+]>>COc1cc2ncnc(Oc3ccc(OCC(=O)N4CCC(N5CCCCC5)CC4)cc3)c2cc1OC",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1ccc(C#N)cc1Br>>COc1ccc(C#N)cc1B1OC(C)(C)C(C)(C)O1",
        "output": "942"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(N)CO.CCOC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2[nH]c1=O>>CC(CO)NC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2[nH]c1=O",
        "output": "498"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC1(C)CCC(=O)c2c(OCOCC[Si](C)(C)C)cc(C#C[Si](C)(C)C)cc21.CO.O=C([O-])[O-].[K+].[K+]>>C#Cc1cc(OCOCC[Si](C)(C)C)c2c(c1)C(C)(C)CCC2=O",
        "output": "337"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC1(c2cccc(NS(C)(=O)=O)c2)C2CN(C(=O)Cc3csc(Cl)c3)CC21.CCOC(C)=O.O.O=C([O-])O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+]>>CC1(c2cccc(NS(C)(=O)=O)c2)C2CN(CCc3csc(Cl)c3)CC21",
        "output": "112"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC(=O)Nc1n[nH]c2ccc([N+](=O)[O-])cc12.CCO.N.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Fe+2]>>CCCC(=O)Nc1n[nH]c2ccc(N)cc12",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COc1ccccc1CN1Cc2ccccc2N=C1N1CCN(C(=O)OC(C)(C)C)CC1.Cl>>COc1ccccc1CN1Cc2ccccc2N=C1N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(C)(C)OC(=O)NCC1CNC1.CC(C)(C)P(c1ccccc1-c1ccccc1)C(C)(C)C.CC(C)(C)[O-].Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=S(=O)(Nc1nccs1)c1ccc(Br)cc1.[Na+].[Pd].[Pd]>>CC(C)(C)OC(=O)NCC1CN(c2ccc(S(=O)(=O)Nc3nccs3)cc2)C1",
        "output": "294"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=O.CC(=O)O.CO.ClCCl.Clc1ccc2c(n1)OC(c1cccnc1)CNC2.[BH3-]C#N>>CN1Cc2ccc(Cl)nc2OC(c2cccnc2)C1",
        "output": "217"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CN.CO.O=C(CCl)Nc1cn2nc(Oc3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)ccc2n1>>CNCC(=O)Nc1cn2nc(Oc3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)ccc2n1",
        "output": "330"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.COc1cc(Br)cc(C)c1N.Cl.O.O=N[O-].O=[PH2]O.[Na+]>>COc1cc(C)cc(Br)c1",
        "output": "324"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C#N)c1ccc(O)c([N+](=O)[O-])c1.CCO.[Pd]>>CC(C#N)c1ccc(O)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CI.Cc1nc2ccccc2[nH]1.O.[K+].[OH-]>>Cc1nc2ccccc2n1C",
        "output": "404"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.ClC(Cl)Cl.O=S(Cl)Cl.OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1>>ClCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1",
        "output": "81"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1C2CCC1CNC2.CN1CCCC1=O.C[Si](C)(C)CCOCN(COCC[Si](C)(C)C)c1cc(Cl)nc2c(-c3ccc(-c4ccccc4)nc3)cnn12.O.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N1C2CCC1CN(c1cc(N(COCC[Si](C)(C)C)COCC[Si](C)(C)C)n3ncc(-c4ccc(-c5ccccc5)nc4)c3n1)C2",
        "output": "162"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "B.C1CCOC1.COc1cc(C#N)c(Cl)cc1C(=O)O.CSC.O>>COc1cc(C#N)c(Cl)cc1CO",
        "output": "72"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2)C1(C#N)c1ccc(Cl)cc1.CC(C)(C)CN.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F>>CC(C)(C)CNC(=O)C1NC(CC(C)(C)C)C(C#N)(c2ccc(Cl)cc2)C1c1cccc(Cl)c1",
        "output": "216"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc(N)ccn1.Cl.ClCCl.O=C(Cl)c1ccc(Br)cc1F.c1ccncc1>>COc1cc(NC(=O)c2ccc(Br)cc2F)ccn1",
        "output": "11"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Nc1ccccc1S(N)(=O)=O.O=S(=O)(Cl)c1ccc2c(c1)CCC2.c1ccncc1>>NS(=O)(=O)c1ccccc1NS(=O)(=O)c1ccc2c(c1)CCC2",
        "output": "68"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrCc1ccc2ccccc2c1.C=CCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2O)cc1>>C=CCOc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCc2ccc3ccccc3c2)cc1",
        "output": "464"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)C(=O)Cl.CCN(CC)CC.Cc1ccccc1.Cl.Nc1cccc(Cl)n1>>CC(C)(C)C(=O)Nc1cccc(Cl)n1",
        "output": "332"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "O.O=C(O)Cc1ccccc1Cc1ccccc1>>O=C1Cc2ccccc2Cc2ccccc21",
        "output": "274"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CCCC1=O.Clc1ccc(C2CC2)nn1.O=C([O-])[O-].O=C(c1ccc(-c2cnco2)cc1)N(C1CCNCC1)C1CC1.[K+].[K+]>>O=C(c1ccc(-c2cnco2)cc1)N(C1CC1)C1CCN(c2ccc(C3CC3)nn2)CC1",
        "output": "406"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COc1cc(Br)ccc1-n1cnc(C)c1.Cc1cc(-c2ccc(F)c(C#N)c2)c2nc(N)nn2c1.ClCCl.ClCCl>>COc1cc(Nc2nc3c(-c4ccc(F)c(C#N)c4)cc(C)cn3n2)ccc1-n1cnc(C)c1",
        "output": "970"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrC(Br)(Br)Br.C1CCOC1.CC(C)Oc1ccc(CO)cc1Cl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)Oc1ccc(CBr)cc1Cl",
        "output": "750"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrCc1ccccc1.CCOC(C)=O.CN(C)C=O.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C(O)c1ccccc1C(=O)c1ccc(O)c([N+](=O)[O-])c1.O=C([O-])[O-].[Cs+].[Cs+]>>O=C(OCc1ccccc1)c1ccccc1C(=O)c1ccc(O)c([N+](=O)[O-])c1",
        "output": "403"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.CC(=O)O.CCOCC.CS(=O)(=O)O.N=C(N)c1ccc(OC(=O)CCCCCNC(=O)OCc2ccccc2)c(C(=O)c2ccccc2)c1>>N=C(N)c1ccc(OC(=O)CCCCCN)c(C(=O)c2ccccc2)c1",
        "output": "574"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCOCCOCCOCCOCCO1.CCCCCCC.CCOC(C)=O.CN(C)C=O.COc1ccc(CBr)cc1.Cc1cnc(Cl)cc1-n1c(C)cc(O)cc1=O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(COc2cc(C)n(-c3cc(Cl)ncc3C)c(=O)c2)cc1",
        "output": "127"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "N#CCc1ccc(F)c(F)c1.O=C([O-])O.O=[N+]([O-])O.[Na+]>>N#CCc1cc(F)c(F)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CS(=O)(=O)n1ccc2c3nc(-c4ccc(N)cc4)nc(N4CCOCC4)c3ccc21.O=C(Cl)C1CC1>>CS(=O)(=O)n1ccc2c3nc(-c4ccc(NC(=O)C5CC5)cc4)nc(N4CCOCC4)c3ccc21",
        "output": "9"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)=O.CI.O=C([O-])[O-].O=[N+]([O-])c1cc(F)cc(Br)c1O.[K+].[K+]>>COc1c(Br)cc(F)cc1[N+](=O)[O-]",
        "output": "62"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COc1cc([N+](=O)[O-])c(C(=O)O)cc1O.[Pd]>>COc1cc(N)c(C(=O)O)cc1O",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=C(c1ccc(N)cc1)c1ccc(Cl)cc1.ClP(Cl)Cl.O=C(O)c1cc(Br)cc(Br)c1O>>C=C(c1ccc(Cl)cc1)c1ccc(NC(=O)c2cc(Br)cc(Br)c2O)cc1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)c1nc(N2CCN(c3ncc(Br)cc3C#N)CC2)no1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cl[Pd]Cl.[Fe+2].[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)c1nc(N2CCN(c3ncc(B4OC(C)(C)C(C)(C)O4)cc3C#N)CC2)no1",
        "output": "943"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)c1ccc2c(c1)OCCn1cc(-c3nc(C)nn3C(C)C)nc1-2.COC(OC)N(C)C>>Cc1nc(-c2cn3c(n2)-c2ccc(C(=O)/C=C/N(C)C)cc2OCC3)n(C(C)C)n1",
        "output": "898"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.COC(=O)c1ccccc1C(=O)c1ccc(Cl)c([N+](=O)[O-])c1.Cl.O=C1OCc2ccc(Cl)cc2N1C1CCNCC1>>COC(=O)c1ccccc1C(=O)c1ccc(N2CCC(N3C(=O)OCc4ccc(Cl)cc43)CC2)c([N+](=O)[O-])c1",
        "output": "105"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Clc1cc(Br)cnc1Cl.NN.O.O>>NNc1ncc(Br)cc1Cl",
        "output": "417"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Nc1ccccc1N.O.O=C(O)CCCCCNC(=O)C=C1c2cc([N+](=O)[O-])ccc2-c2ccc([N+](=O)[O-])cc21.Oc1cccc2[nH]nnc12.[Cl-].[Na+]>>Nc1ccccc1NC(=O)CCCCCNC(=O)C=C1c2cc([N+](=O)[O-])ccc2-c2ccc([N+](=O)[O-])cc21",
        "output": "365"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CC(C)C(=O)Cl.ClCCl>>CC(C)C(=O)N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "125"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.COc1ccc(CNc2ccc(C#N)cc2N)c(OC)c1.N#CSc1nc(Cl)ncc1[N+](=O)[O-].O=C([O-])[O-].[K+].[K+]>>COc1ccc(CNc2ccc(C#N)cc2Nc2ncc([N+](=O)[O-])c(SC#N)n2)c(OC)c1",
        "output": "808"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)OC(C)(C)C)cc1.Cl.O.O.O.O.[Li+].[OH-]>>CC(C)(C)OC(=O)NCCOCCOCCNC(=O)c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)CCc1ccc(C(=O)c2ccc(Cl)cc2)n1C.[Na+].[OH-]>>Cn1c(CCC(=O)O)ccc1C(=O)c1ccc(Cl)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCc1nnc(NC(=O)OCC(Cl)(Cl)Cl)o1.CS(C)=O.O.c1ccc(-c2nsc(N3CCNCC3)n2)cc1>>CCc1nnc(NC(=O)N2CCN(c3nc(-c4ccccc4)ns3)CC2)o1",
        "output": "980"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)O.CC1(C)C(=O)C(C)(C)c2cc(C(=O)CN3CCN(c4nsc5ccccc45)CC3)ccc21.CO.[BH4-].[Na+]>>CC1(C)C(=O)C(C)(C)c2cc(C(O)CN3CCN(c4nsc5ccccc45)CC3)ccc21",
        "output": "24"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)CBr.CN(C)C=O.Cc1cc(Cl)cc2[nH]c3ccccc3c12.[H-].[Na+]>>Cc1cc(Cl)cc2c1c1ccccc1n2CC(C)C",
        "output": "470"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.ClCCl.Cn1c(=O)oc2ccc(-c3cncc(F)c3C=O)cc21.O.O.[BH4-].[Cl-].[Na+].[Na+]>>Cn1c(=O)oc2ccc(-c3cncc(F)c3CO)cc21",
        "output": "356"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN(C)C=O.CS(=O)(=O)c1cncc(Cl)n1.O=C([O-])[O-].Oc1cccc(I)c1.[K+].[K+]>>CS(=O)(=O)c1cncc(Oc2cccc(I)c2)n1",
        "output": "210"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.O.O=S(=O)(O)O.OC(c1ccccc1)(c1ccccc1)C(CCOC1CCCCO1)c1ccccc1.[Na+].[OH-]>>OCCC(c1ccccc1)C(O)(c1ccccc1)c1ccccc1",
        "output": "543"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CC[C@H]1CN(Cc2ccccc2)[C@H](C)CN1.ClCCl>>CC[C@H]1CN(Cc2ccccc2)[C@H](C)CN1C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.CCN(C(C)C)C(C)C.CCOC(C)=O.COC(=O)[C@H]1CNC[C@H]1NC(=O)c1ccc(Cc2cc(C)nc3ccccc23)cc1.ClCCl.[Na+]>>COC(=O)[C@H]1CN(C(C)C)C[C@H]1NC(=O)c1ccc(Cc2cc(C)nc3ccccc23)cc1",
        "output": "187"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(=O)Cl.CNc1cccc(S(=O)(=O)N(C[C@@H](O)[C@H](Cc2ccccc2)NC(=O)O[C@H]2CO[C@H]3OCC[C@@H]23)CC(C)(C)CCCN)c1>>CNc1cccc(S(=O)(=O)N(C[C@@H](O)[C@H](Cc2ccccc2)NC(=O)O[C@H]2CO[C@H]3OCC[C@@H]23)CC(C)(C)CCCNC(=O)N(C)C)c1",
        "output": "454"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Clc1ccccc1OC1CNC1.O=C(O)CNC(=O)c1cn(-c2ccccc2)cn1.On1nnc2ccccc21>>O=C(NCC(=O)N1CC(Oc2ccccc2Cl)C1)c1cn(-c2ccccc2)cn1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CNc1nc(C)cc(Cl)n1.O=C(c1cc(F)ccc1-n1nccn1)N1CC[C@H]2CN[C@H]2C1.c1ccc2nc(N3CC4CCNCC43)cnc2c1>>CNc1nc(C)cc(N2C[C@@H]3CCN(C(=O)c4cc(F)ccc4-n4nccn4)C[C@@H]32)n1",
        "output": "162"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1CCCC1=O.COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1O.Cl.ClCCCOc1ccncc1.O.O=C([O-])[O-].[K+].[K+]>>COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCCOc1ccncc1",
        "output": "74"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.ClCCl.Cn1nc(C(F)(F)F)cc1-c1c(F)cc(N)cc1F.O=C(Cl)c1c(F)cccc1F.O=C([O-])O.[Na+]>>Cn1nc(C(F)(F)F)cc1-c1c(F)cc(NC(=O)c2c(F)cccc2F)cc1F",
        "output": "11"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)=CCOc1ccc(OCCO)cc1.CC(C)N=C=O>>CC(C)=CCOc1ccc(OCCOC(=O)NC(C)C)cc1",
        "output": "235"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCCCC1CCCCC1.CCN(CC)CC.CN(C)C=O.C[C@@H]1COC(=O)N1CCc1ccc(Br)s1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O.[Cu]I>>C[C@@H]1COC(=O)N1CCc1ccc(C#CCCCC2CCCCC2)s1",
        "output": "766"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)CN(CC(C)C)c1ccc([N+](=O)[O-])cc1F.CO.ClCCl.[Pd]>>CC(C)CN(CC(C)C)c1ccc(N)cc1F",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCN1CCNCC1.CCc1nccc(-c2ccc(C(=O)O)c(OC)c2)c1C#Cc1ccc(N)nc1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O>>CCc1nccc(-c2ccc(C(=O)N3CCN(CC)CC3)c(OC)c2)c1C#Cc1ccc(N)nc1",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.CO.COC(=O)c1ccc(C(CC(C)C)Nc2ccc(-c3ccc(C(C)(C)C)cc3)cc2)cc1.[Na+].[OH-]>>CC(C)CC(Nc1ccc(-c2ccc(C(C)(C)C)cc2)cc1)c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@@H]1CC[C@@H](CN)CC1.ClCCl.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F>>CCOC(=O)NC[C@@H]1CC[C@@H](n2c([C@@H](C)O)nc3cnc4ccsc4c32)CC1",
        "output": "94"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CC(C)(C)C1CCC(=O)CC1.CO.O=C[O-].[Ir].[NH4+]>>CC(C)(C)C1CCC(N)CC1",
        "output": "63"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=O.O.O=C(c1cc2cc(F)ccc2o1)C1CNCCN1C(=O)OCc1ccccc1.O=CO.[Na+].[OH-]>>CN1CCN(C(=O)OCc2ccccc2)C(C(=O)c2cc3cc(F)ccc3o2)C1",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCCCCCCCCCCCCCCCCCCCCOc1ccc(C=O)c(OCCCCCCCCCCCCCCCCCCCCCC)c1.CO.[BH4-].[Na+]>>CCCCCCCCCCCCCCCCCCCCCCOc1ccc(CO)c(OCCCCCCCCCCCCCCCCCCCCCC)c1",
        "output": "356"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.Cc1cccc(N=C=O)c1.Cc1ccccc1>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(C)c4)cc3)c2cc1OC",
        "output": "912"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CSCCCCO.N#Cc1c([N+](=O)[O-])cccc1[N+](=O)[O-]>>CSCCCCOc1cccc([N+](=O)[O-])c1C#N",
        "output": "499"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC1CN(c2ccc(-c3nc4c(-c5ccc(OC6CCNCC6)c(C#N)c5)ncnc4[nH]3)cc2)CCN1CCF.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)CO>>CC1CN(c2ccc(-c3nc4c(-c5ccc(OC6CCN(C(=O)CO)CC6)c(C#N)c5)ncnc4[nH]3)cc2)CCN1CCF",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCCCC1.CCOC(C)=O.Clc1nc(NCC(c2ccccc2)c2ccccc2)c2ccccc2n1.Cn1ncc2cc(B(O)O)ccc21.c1ccc(C(Nc2nc(-c3cc4ccccc4s3)nc3ccccc23)c2ccccc2)cc1>>Cn1ncc2cc(-c3nc(NCC(c4ccccc4)c4ccccc4)c4ccccc4n3)ccc21",
        "output": "874"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#CCNC(=O)CN1CCCC1.CCN(CC)CC.COc1ccc2c(OCCn3cc(Br)ccc3=O)ccnc2c1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>COc1ccc2c(OCCn3cc(C#CCNC(=O)CN4CCCC4)ccc3=O)ccnc2c1",
        "output": "719"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCN(CCCC)CCCCl.Cl.O.Oc1ccccc1.[Na+].[OH-]>>CCCCN(CCCC)CCCOc1ccccc1",
        "output": "74"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CC(=O)O.CCCCC(CC)(CN)CN(C)C.c1ccc(Nc2ccc(Nc3ccccc3)cc2)cc1>>C=CC(=O)NCC(CC)(CCCC)CN(C)C",
        "output": "549"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCCCCC.CCOC(C)=O.CCOC(C)=O.COCOc1ccc(-c2ccc3cn[nH]c3c2)cc1OC.II.II.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=S([O-])O.[Na+].[Na+].[OH-]>>COCOc1ccc(-c2ccc3c(I)n[nH]c3c2)cc1OC",
        "output": "923"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(N3CCC(=O)CC3)cc2)cc1.COc1ccc(OCC(O)CN)cc1>>COc1ccc(OCC(O)CNC2CCN(c3ccc(NS(=O)(=O)c4ccc(NC(C)=O)cc4)cc3)CC2)cc1",
        "output": "236"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.O.O=C[O-].OC[C@@H]1CC2(CC2)CN1Cc1ccccc1.[NH4+].[Pd]>>OC[C@@H]1CC2(CC2)CN1",
        "output": "84"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)c1cn(CC)c2c(F)c(C)c(F)cc2c1=O.[Na+].[OH-]>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(C)c(F)c21",
        "output": "171"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(CCN)cc1.O.O=C(O)C1(c2ccc(Cl)cc2)CC1>>COc1ccc(CCNC(=O)C2(c3ccc(Cl)cc3)CC2)cc1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Cc1ccc(C2=C(C(=O)O)CCCC2)cc1.Cl.F[P-](F)(F)(F)(F)F.Nc1ccc(NC(=O)Cn2cccn2)cc1.O.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>Cc1ccc(C2=C(C(=O)Nc3ccc(NC(=O)Cn4cccn4)cc3)CCCC2)cc1",
        "output": "170"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C[C@@H](NC(=O)[C@H](N)CCCNC(=O)OCc1ccccc1)c1ccc(O)cc1.Cl.O=C(Cl)C(c1ccccc1)c1ccccc1.O=C([O-])O.[Na+]>>C[C@@H](NC(=O)[C@@H](CCCNC(=O)OCc1ccccc1)NC(=O)C(c1ccccc1)c1ccccc1)c1ccc(O)cc1",
        "output": "159"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.C[Si](C)(C)C#Cc1ccc(C2(NCc3ccccc3)CC2)cc1.O=C([O-])[O-].[K+].[K+]>>C#Cc1ccc(C2(NCc3ccccc3)CC2)cc1",
        "output": "337"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl.OCCCCCCCCOc1ccc2ccccc2n1>>O=CCCCCCCCOc1ccc2ccccc2n1",
        "output": "142"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COCc1cc(C(=O)OC)cc(-c2ccc(C)cn2)c1.O.O=S(=O)(O)O.[Li+].[OH-]>>COCc1cc(C(=O)O)cc(-c2ccc(C)cn2)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CO.O=C(O)CCCc1ccc(N(CCCl)CCCl)cc1>>COC(=O)CCCc1ccc(N(CCCl)CCCl)cc1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.ClCCl.NC(=O)c1ccsc1N.O=C(O)Cn1nc(C(F)(F)F)c2c1CCCC2.O=C(n1ccnc1)n1ccnc1>>NC(=O)c1ccsc1NC(=O)Cn1nc(C(F)(F)F)c2c1CCCC2",
        "output": "882"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.O=C(O)c1cccc2ncccc12.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1cccc2ncccc12",
        "output": "72"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCCc1ccc(Oc2nc3ccccc3s2)cc1.CC#N.CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2.CCN(CC)CC>>CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2CCc1ccc(Oc2nc3ccccc3s2)cc1",
        "output": "73"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)CCNS(=O)(=O)c1cccc(N)c1.O=C(O)c1cnn2c(C(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12>>CN(C)CCNS(=O)(=O)c1cccc(NC(=O)c2cnn3c(C(F)F)cc(-c4ccc(C(F)(F)F)cc4)nc23)c1",
        "output": "969"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "N#Cc1ccc(C(=O)CBr)cc1.Nc1ccc(Br)cn1>>N#Cc1ccc(-c2cn3cc(Br)ccc3n2)cc1",
        "output": "508"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)c1cc(CC(CNS(C)(=O)=O)NC(=O)OCc2ccccc2)ccc1OCc1ccccc1.CO.ClCCl.[H][H].[OH-].[OH-].[Pd+2]>>CC(C)(C)c1cc(CC(N)CNS(C)(=O)=O)ccc1OCc1ccccc1",
        "output": "574"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COC(=O)C1(NC(=O)c2cc3ccccc3cc2NC(=O)Nc2c(C)cc(-c3ccccc3)cc2C)CCCCCC1.Cl.O.O.[Li+].[OH-]>>Cc1cc(-c2ccccc2)cc(C)c1NC(=O)Nc1cc2ccccc2cc1C(=O)NC1(C(=O)O)CCCCCC1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)c1nc(Cl)nc(N2CCOCC2)c1OCC.[BH4-].[Na+]>>CCOc1c(CO)nc(Cl)nc1N1CCOCC1",
        "output": "711"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CC[NH+](CC)CC.O=P(Cl)(Cl)Cl.O=c1ccc2c(OCCN3CCOCC3)ccc(Cl)c2[nH]1.[Cl-]>>Clc1ccc2c(OCCN3CCOCC3)ccc(Cl)c2n1",
        "output": "100"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.CCOC(=O)N1c2ccc(OC)nc2[C@H](N)C[C@@H]1CC.Clc1ncc(Br)cn1>>CCOC(=O)N1c2ccc(OC)nc2[C@H](Nc2ncc(Br)cn2)C[C@@H]1CC",
        "output": "544"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCCN(Cc1ccc(OCC(=O)OCC)c(C)c1)c1nccc(-c2ccc(Cl)cc2)n1.CO.[Na+].[OH-]>>CCCCN(Cc1ccc(OCC(=O)O)c(C)c1)c1nccc(-c2ccc(Cl)cc2)n1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCn1c(=O)c(-c2cc(N)c(F)cc2Cl)cc2cnc(Cl)cc21.N#Cc1cccc(N=C=O)c1.c1ccncc1>>CCn1c(=O)c(-c2cc(NC(=O)Nc3cccc(C#N)c3)c(F)cc2Cl)cc2cnc(Cl)cc21",
        "output": "473"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CCOc1ccc(S(C)(=O)=O)cc1.O.O=C1O[C@H]([C@@H](O)CO)C([O-])=C1O.O=S(=O)([O-])[O-].[Cu+2].[N-]=[N+]=NC1CCC(Oc2ncccn2)CC1.[Na+]>>CS(=O)(=O)c1ccc(OCc2cn(C3CCC(Oc4ncccn4)CC3)nn2)cc1",
        "output": "963"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.CCCCCCBr.O=C([O-])[O-].Oc1ccc(Br)cc1.[K+].[K+]>>CCCCCCOc1ccc(Br)cc1",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)[N-]C(C)C.II.N#Cc1ccc(F)cc1C(F)(F)F.[Li+]>>N#Cc1ccc(F)c(I)c1C(F)(F)F",
        "output": "372"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCC2=NCCCN2CC1.CC#N.C[Si](C)(C)CCOCCl.Cc1c(Br)n(C)c(=O)[nH]c1=O>>Cc1c(Br)n(C)c(=O)n(COCC[Si](C)(C)C)c1=O",
        "output": "712"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1cccc(Nc2cnc(OC)c3c2CCCC3)c1.C[Si](C)(C)I.ClC(Cl)Cl>>CCOC(=O)c1cccc(Nc2c[nH]c(=O)c3c2CCCC3)c1",
        "output": "758"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(O)CC1.CCN(CC)CC.CS(=O)(=O)Cl.Cc1ccccc1>>CC(C)(C)OC(=O)N1CCC(OS(C)(=O)=O)CC1",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.N#Cc1cnc2cnc(F)cc2c1Cl.Nc1cccc(Br)c1>>N#Cc1cnc2cnc(F)cc2c1Nc1cccc(Br)c1",
        "output": "115"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOC(C)=O.CN1C(=O)NC2(C1=O)c1cc(Br)ccc1OC1CC(O)CCC12.ClCCl.O.c1c[nH]cn1>>CN1C(=O)NC2(C1=O)c1cc(Br)ccc1OC1CC(O[Si](C)(C)C(C)(C)C)CCC12",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc2c(cc1OC)C(Cc1ccc3ccccc3c1)NCC2.N[C@@H]1c2ccccc2C[C@@H]1O.O=C(Br)CBr>>COc1cc2c(cc1OC)C(Cc1ccc3ccccc3c1)N(CC(=O)N[C@@H]1c3ccccc3C[C@@H]1O)CC2",
        "output": "946"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)Cl.CCN(CC)CC.COCCc1cc(N2CCN(CC[C@@H]3CC[C@@H](N)CC3)CC2)nc(C(C)(C)C)n1.ClCCl>>COCCc1cc(N2CCN(CC[C@@H]3CC[C@@H](NC(C)=O)CC3)CC2)nc(C(C)(C)C)n1",
        "output": "45"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCc1ccccc1.CC(C)(C)OC(=O)N1CCC(c2ccc(O)cc2)C(O)C1.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCC(c2ccc(OCc3ccccc3)cc2)C(O)C1",
        "output": "127"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)C1CN(Cc2ccccc2)CCC1=O.CO.[BH4-].[Na+]>>CC(C)C1CN(Cc2ccccc2)CCC1O",
        "output": "91"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1C(=O)C(F)(F)CN(C2CCC2)c2nc(Nc3ccc(C(=O)O)cc3)ncc21.Cl.F[P-](F)(F)(F)(F)F.O=C(NC1CCNCC1)OCC1c2ccccc2-c2ccccc21>>CN1C(=O)C(F)(F)CN(C2CCC2)c2nc(Nc3ccc(C(=O)N4CCC(NC(=O)OCC5c6ccccc6-c6ccccc65)CC4)cc3)ncc21",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(C(=O)O)c([N+](=O)[O-])c1.O=S(Cl)Cl>>COc1ccc(C(=O)Cl)c([N+](=O)[O-])c1",
        "output": "3"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)CBr.CCCC[N+](CCCC)(CCCC)CCCC.C[C@H](c1ccccc1)N1CC[C@@H](CO)C1.Cc1ccccc1.O.[Br-].[Na+].[OH-]>>C[C@H](c1ccccc1)N1CC[C@@H](COCC(=O)OC(C)(C)C)C1",
        "output": "669"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC2(CCNC2)CC1.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1nc(F)ccc1S(C)(=O)=O.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>>Cc1nc(N2CCC3(CCN(C(=O)OC(C)(C)C)CC3)C2)ccc1S(C)(=O)=O",
        "output": "756"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CO.Nc1ccc(F)cc1.O=C1CCOCC1.[BH3-]C#N.[Na+].[Na+].[OH-]>>Fc1ccc(NC2CCOCC2)cc1",
        "output": "469"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClCc1ccc(Cl)cc1.O=c1cc2c(n[nH]1)-c1cc(Br)sc1SCC2>>O=c1cc2c(nn1Cc1ccc(Cl)cc1)-c1cc(Br)sc1SCC2",
        "output": "842"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)CSc1nc(C(=O)O)ccc1Br.CO.O.O=S(=O)(O)O.[Cl-].[Na+]>>COC(=O)c1ccc(Br)c(SCC(C)C)n1",
        "output": "331"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1cc(F)c(Br)cc1C=O.N#Cc1ccc(B(O)O)cc1>>COc1cc(F)c(-c2ccc(C#N)cc2)cc1C=O",
        "output": "837"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)CC(=O)c1cccc(-c2ccc(C3CC3)nc2)c1.CCc1cc(NC(=O)OC(C)(C)C)c(N)cc1C(F)(F)F>>CCc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3ccc(C4CC4)nc3)c2)cc1C(F)(F)F",
        "output": "929"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN.O.O=C(Cl)N1CC(Oc2cc(C(F)(F)F)ccc2Cl)C1>>CNC(=O)N1CC(Oc2cc(C(F)(F)F)ccc2Cl)C1",
        "output": "454"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1sc2ccc(C(F)(F)F)cc2c1OC.O.O.[Li+].[OH-]>>COc1c(C(=O)O)sc2ccc(C(F)(F)F)cc12",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOCC.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.OCCOCC(O)c1ccc(OCc2ccccc2)cc1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCCOCC(O)c2ccc(OCc3ccccc3)cc2)cc1",
        "output": "197"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)[C@H](Cc1ccc(-c2c3ccccc3cc3ccccc23)cc1)NC(C)=O.O.O.O.[Li+].[OH-]>>CC(=O)N[C@@H](Cc1ccc(-c2c3ccccc3cc3ccccc23)cc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(N)CO.CCNc1cccnc1N1CCN(C(=O)c2ccc(C(=O)O)cn2)CC1>>CCNc1cccnc1N1CCN(C(=O)c2ccc(C(=O)NC(C)(C)CO)cn2)CC1",
        "output": "674"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(CC)CC.CNc1ccc(CC2CCN([C@H](C)c3ccccc3)C2=O)cc1.O=C([O-])O.[Na+]>>CC(=O)N(C)c1ccc(CC2CCN([C@H](C)c3ccccc3)C2=O)cc1",
        "output": "160"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NCCN1CCNC1=O.O=C=Nc1ccccc1.c1ccccc1>>O=C(NCCN1CCNC1=O)Nc1ccccc1",
        "output": "35"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)c1ccc([N+](=O)[O-])cc1S(N)(=O)=O.CCO.CCOC(C)=O.Cl[Sn]Cl.O.O=C([O-])O.[Na+]>>CC(C)(C)c1ccc(N)cc1S(N)(=O)=O",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O=C(O)Cc1ccccc1Cl.O=S(=O)(O)O>>COC(=O)Cc1ccccc1Cl",
        "output": "17"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.O.O=C(Cl)OCC1c2ccccc2-c2ccccc21.O=C(O)C1CCNCC1.O=C([O-])[O-].[Na+].[Na+]>>O=C(O)C1CCN(C(=O)OCC2c3ccccc3-c3ccccc32)CC1",
        "output": "219"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(=O)CC1.NCCC[C@H](NC(=O)OCc1ccccc1)C(=O)O.O.[BH3-]C#N.[Na+]>>CC(C)(C)OC(=O)N1CCC(NCCC[C@H](NC(=O)OCc2ccccc2)C(=O)O)CC1",
        "output": "236"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=C(O)C1(c2ccccc2)CC1.O=S(=O)(O)O>>COC(=O)C1(c2ccccc2)CC1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.[N-]=[N+]=NCc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(Cl)cc2)CC1>>NCc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(Cl)cc2)CC1",
        "output": "89"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCC1(O)CCC2(CC1)OCCO2.CCOCC.O.O=[Os](=O)(=O)=O>>O=CCC1(O)CCC2(CC1)OCCO2",
        "output": "571"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CNC(=O)c1cc(N2CCNCC2)ccn1.Cl.ClCCl.O=C(Cl)C(=O)Cl.O=C(O)/C=C/C(F)(F)C(F)F>>CNC(=O)c1cc(N2CCN(C(=O)/C=C/C(F)(F)C(F)F)CC2)ccn1",
        "output": "870"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CS(C)=O.O=C([O-])[O-].O=Cc1ccc(F)cc1.[K+].[K+].c1c[nH]cn1>>O=Cc1ccc(-n2ccnc2)cc1",
        "output": "721"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=CC(=O)Cl.CCN(CC)CC.CCOCC.OCCCCCCC[C@@H]1CC[C@@H](c2cccc(F)c2F)CC1>>C=CC(=O)OCCCCCCC[C@@H]1CC[C@@H](c2cccc(F)c2F)CC1",
        "output": "320"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "NC[C@H]1CN(c2ccc3c(c2)CCCc2cnoc2-3)C(=O)O1.O=C(O)CC1CCCC1>>O=C(CC1CCCC1)NC[C@H]1CN(c2ccc3c(c2)CCCc2cnoc2-3)C(=O)O1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)NS(=O)(=O)c1cccc(B(O)O)c1.Fc1cc(C(F)(F)F)ccc1-c1cc(C(F)(F)F)nc(-c2cccc(Br)c2)n1>>CC(C)(C)NS(=O)(=O)c1cccc(-c2cccc(-c3nc(-c4ccc(C(F)(F)F)cc4F)cc(C(F)(F)F)n3)c2)c1",
        "output": "837"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCCCO.CCOC(C)=O.COc1cc(F)ccc1-c1nc(Cl)ncc1F.CSCc1cc(N)cc(Br)c1.Cl>>COc1cc(F)ccc1-c1nc(Nc2cc(Br)cc(CSC)c2)ncc1F",
        "output": "808"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.CN[C@H]1CCCN(C(=O)CNc2cc(Cl)cc(Cl)c2)C1.Nc1nccc(Cl)n1>>CN(c1ccnc(N)n1)[C@H]1CCCN(C(=O)CNc2cc(Cl)cc(Cl)c2)C1",
        "output": "162"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)CCc1ccc(N)cc1.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl.c1ccncc1>>COC(=O)CCc1ccc(NS(=O)(=O)c2ccccc2[N+](=O)[O-])cc1",
        "output": "68"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)[C@H]1CCc2[nH]ncc2C1.O.O.[Li+].[OH-]>>O=C(O)[C@H]1CCc2[nH]ncc2C1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCN(CCC)CCC.CCCN(CCC)CCC.ClC(Cl)Cl.Cn1c(=O)[nH]c(=O)c2ccccc21.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>Cn1c(=O)nc(Cl)c2ccccc21",
        "output": "14"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(O)CN.CCN(C(C)C)C(C)C.O=S(=O)(Cl)c1ccc(CBr)cc1>>CC(C)(O)CNS(=O)(=O)c1ccc(CBr)cc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)c1ccc(C(=O)Cl)cc1.CCN(C(C)C)C(C)C.Nc1c(Br)cccc1Br>>CC(C)(C)c1ccc(C(=O)Nc2c(Br)cccc2Br)cc1",
        "output": "11"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCC.CCN(CC)CC.CCOC(C)=O.CCOC(C)=O.CCOP(=O)(C#N)OCC.CN(C)C=O.COC(=O)[C@@H](C)N.COc1cccc([C@H]2O[C@H](CC(=O)O)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC.Cl>>COC(=O)[C@@H](C)NC(=O)C[C@H]1O[C@H](c2cccc(OC)c2OC)c2cc(Cl)ccc2N(CC(C)(C)CO)C1=O",
        "output": "129"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CN(C)C=O.Cc1cc(C#N)ncc1-c1cc(C(=O)N(C)c2cccc(C)c2OCCC(=O)O)ccc1Cl.ClCCl.O=C(Cl)C(=O)Cl>>CCOC(=O)CCOc1c(C)cccc1N(C)C(=O)c1ccc(Cl)c(-c2cnc(C#N)cc2C)c1",
        "output": "17"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCC(N)CC1.F[P-](F)(F)(F)(F)F.Nc1ccc(C(=O)O)cn1>>CN1CCC(NC(=O)c2ccc(N)nc2)CC1",
        "output": "674"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.Cc1cc(Br)cnc1Br.O=C([O-])O.[Na+]>>Cc1cc(Br)cnc1OC(C)C",
        "output": "551"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCNCC.Cl.O=C(O)COc1cc2c(c(Cl)c1Cl)C(=O)C(C1CCCC1)CC2.O=S(Cl)Cl.c1ccccc1>>CCN(CC)C(=O)COc1cc2c(c(Cl)c1Cl)C(=O)C(C1CCCC1)CC2",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCN(c2ccc(C(=O)Nc3nn(C(=O)OC(C)(C)C)c4cc(OCc5cccc(Oc6ccccc6)c5)ccc34)cc2)CC1.CO.ClCCl.ClCCl.O=C(O)C(F)(F)F>>CN1CCN(c2ccc(C(=O)Nc3n[nH]c4cc(OCc5cccc(Oc6ccccc6)c5)ccc34)cc2)CC1",
        "output": "896"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.COc1cncc(-c2cnc(N3CCOCC3)cc2N)c1.Cc1c(N2CCCC2=O)nc2cc(F)cc(F)c2c1Cl.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>COc1cncc(-c2cnc(N3CCOCC3)cc2Nc2c(C)c(N3CCCC3=O)nc3cc(F)cc(F)c23)c1",
        "output": "115"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCN.CCOCC.O=Cc1ccccc1S(=O)(=O)CCCCCl.O=S(=O)(O)O.O=S(=O)([O-])[O-].[Mg+2]>>CCCCN=Cc1ccccc1S(=O)(=O)CCCCCl",
        "output": "52"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1n[nH]c2c1CNCC2.ClCCl.O=C=Nc1cccc(Cl)c1>>CCOC(=O)c1n[nH]c2c1CN(C(=O)Nc1cccc(Cl)c1)CC2",
        "output": "323"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCN1.COc1cnc(-c2ccc([N+](=O)[O-])cc2)nc1Cl.ClCCl.[Cl-].[NH4+]>>COc1cnc(-c2ccc([N+](=O)[O-])cc2)nc1N1CCOCC1",
        "output": "162"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1=COCCC1.C1CCOC1.Cc1ccc(S(=O)(=O)O)cc1.OCC1(n2ccc3cncnc32)CC1>>c1ncc2ccn(C3(COC4CCCCO4)CC3)c2n1",
        "output": "306"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.C[O-].Cc1nc(C#Cc2cccc(Cl)c2)cn1-c1ccc(Cl)nn1.O.[Na+]>>COc1ccc(-n2cc(C#Cc3cccc(Cl)c3)nc2C)nn1",
        "output": "407"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.O.O=[N+]([O-])c1cc(-c2ccc([C@@H](O)C(F)F)cc2)cc([N+](=O)[O-])c1.[Cl-].[Fe].[NH4+]>>Nc1cc(N)cc(-c2ccc([C@@H](O)C(F)F)cc2)c1",
        "output": "204"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN.COc1ccc2c(c1)c(OC(C)C)c(C(=O)O)n2C.[NH4+].[OH-]>>CNC(=O)c1c(OC(C)C)c2cc(OC)ccc2n1C",
        "output": "137"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.Cc1onc(-c2ccccc2)c1C(=O)O.Cl.Cl.ClCCl.O=C(c1ccc(F)cc1)C1CCNCC1>>Cc1onc(-c2ccccc2)c1C(=O)N1CCC(C(=O)c2ccc(F)cc2)CC1",
        "output": "975"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)CCON=O.CCO.CCOC(=O)c1nn(-c2ccc(C(F)(F)F)cc2N)nc1Oc1cccc(OC(F)(F)F)c1.O=PO.O=S(=O)(O)O.[Cl-].[Na+]>>CCOC(=O)c1nn(-c2ccc(C(F)(F)F)cc2)nc1Oc1cccc(OC(F)(F)F)c1",
        "output": "324"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CS(=O)c1ccccc1C1CCN(C(=O)OCc2ccccc2)CC1.O=C(O)C(F)(F)F>>CS(=O)c1ccccc1C1CCNCC1",
        "output": "428"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COC(=O)c1cnc(Cl)cn1.O.O=C([O-])[O-].OC1CC1.[K+].[K+]>>COC(=O)c1cnc(OC2CC2)cn1",
        "output": "209"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)OC(=O)N=NC(=O)OC(C)C.CN1CCN(CCCO)CC1.COc1cc2c(Cl)c(C#N)cnc2cc1O.ClCCl.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc2c(Cl)c(C#N)cnc2cc1OCCCN1CCN(C)CC1",
        "output": "478"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.C[Si](C)(C)C=[N+]=[N-].O=C(O)[C@@H]1CC[C@@H](C(=O)O)CC1>>COC(=O)[C@@H]1CC[C@@H](C(=O)O)CC1",
        "output": "17"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cl.Cl.ClC(Cl)Cl.O=C([O-])O.Oc1ccc2c(c1)CCNC2.[Na+]>>CC(C)(C)OC(=O)N1CCc2cc(O)ccc2C1",
        "output": "867"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC[C@H]1COc2cc(C(=O)OC)ccc2CN1C.NO.[Na+].[OH-]>>COC[C@H]1COc2cc(C(=O)NO)ccc2CN1C",
        "output": "988"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.ClCCl.NCCc1ccccc1.O=C(O)c1ccc(C(F)(F)F)c(F)c1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>O=C(NCCc1ccccc1)c1ccc(C(F)(F)F)c(F)c1",
        "output": "334"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(Br)cc(OCc3ccccc3)c2)c1CCC(=O)OCC.Cl[Pd]Cl.O=C([O-])[O-].OB(O)c1cccc(F)c1.[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(OCc3ccccc3)cc(-c3cccc(F)c3)c2)c1CCC(=O)OCC",
        "output": "837"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCN(C[C@@H]2CCCN2)CC1.O=C1Nc2cccnc2N(C(=O)CCl)c2ccccc21>>CN1CCN(C[C@@H]2CCCN2CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1",
        "output": "340"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCN.CCO.Nc1nc(Cl)cc(Cl)n1.O>>CCCCCCNc1cc(Cl)nc(N)n1",
        "output": "166"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(Oc1ccc(Oc2ncc(Cl)cc2F)cc1)C(=O)O.Cc1ccccc1.O=S(Cl)Cl>>CC(Oc1ccc(Oc2ncc(Cl)cc2F)cc1)C(=O)Cl",
        "output": "53"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.ClCc1ccccc1.O=S([O-])S(=O)[O-].Oc1ccc(O)c2ccccc12.[K+].[Na+].[Na+].[OH-]>>Oc1ccc(OCc2ccccc2)c2ccccc12",
        "output": "49"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.Cl.O=C(O)c1ccc(O)c([N+](=O)[O-])c1.c1ccncc1>>CC(=O)Oc1ccc(C(=O)O)cc1[N+](=O)[O-]",
        "output": "46"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C(N)=O)c1cccc(C2CCNCC2)c1.CC(C)(C)OC(=O)N1CC=C(c2ccc([N+](=O)[O-])cc2)CC1.Cl>>O=[N+]([O-])c1ccc(C2=CCNCC2)cc1",
        "output": "800"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCCCCCC.Nc1cccc(Br)c1.[Na+].[OH-]>>CC(C)(C)OC(=O)Nc1cccc(Br)c1",
        "output": "735"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCCO.COc1cc2c(Cl)c(C#N)cnc2cc1F.Cl.Nc1ccc(Sc2ccccn2)cc1.c1ccncc1>>COc1cc2c(Nc3ccc(Sc4ccccn4)cc3)c(C#N)cnc2cc1F",
        "output": "115"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.CCI.CCOC(C)=O.COC(=O)c1ccc2c(c1)CCNCC2.O=C([O-])[O-].[K+].[K+]>>CCN1CCc2ccc(C(=O)OC)cc2CC1",
        "output": "184"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1ccccc1Sc1cccc(Br)c1.CN(C)C=O.O.[C-]#N.[Na+]>>N#CCc1ccccc1Sc1cccc(Br)c1",
        "output": "39"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1cccc(S(=O)(=O)NCC2CC2)c1.O=C(O)c1cnn2c(C(F)(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12>>O=C(Nc1cccc(S(=O)(=O)NCC2CC2)c1)c1cnn2c(C(F)(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12",
        "output": "969"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN1C(=O)CCCc2c1ccc(N)c2OC.Clc1ncc(Cl)c(Nc2ccccc2-n2cccn2)n1>>CCN1C(=O)CCCc2c1ccc(Nc1ncc(Cl)c(Nc3ccccc3-n3cccn3)n1)c2OC",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Fc1cnc(Cl)nc1Nc1ccc2ncccc2c1.Nc1cccc(O)c1>>Oc1cccc(Nc2ncc(F)c(Nc3ccc4ncccc4c3)n2)c1",
        "output": "808"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCCCCCCCCCCC(O)C(=O)O.CO>>CCCCCCCCCCCCCCC(O)C(=O)OC",
        "output": "17"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CNC(=O)C1CCNCC1.Cc1ccc(-c2oncc2C(=O)O)cc1>>CNC(=O)C1CCN(C(=O)c2cnoc2-c2ccc(C)cc2)CC1",
        "output": "975"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)C1(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1.Cc1noc(-c2ccc(Br)cc2)c1C(O)C(=O)NCc1ccccc1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4C(O)C(=O)NCc4ccccc4)cc3)cc2)CC1",
        "output": "933"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.Cc1ccc(-c2ncc[nH]2)cc1[N+](=O)[O-].[Pd]>>Cc1ccc(-c2ncc[nH]2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1.CO.ClCCl>>CCN1CCN(Cc2ccc(N)cc2)CC1",
        "output": "507"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CN1CCN(Cc2cc(Cl)c(F)c(CNC(=O)OC(C)(C)C)c2)CC1.Cl>>CN1CCN(Cc2cc(Cl)c(F)c(CN)c2)CC1",
        "output": "793"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=C(C(N)=O)c1ccc(C(=O)O)cc1.O=S(Cl)Cl>>C=C(C(N)=O)c1ccc(C(=O)Cl)cc1",
        "output": "3"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCCl.CC(C)(C)c1ccc(O)cc1.CCC(C)=O.O=C([O-])[O-].[K+].[K+]>>C=CCOc1ccc(C(C)(C)C)cc1",
        "output": "119"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCC(CCCN)OC1CCCCO1.CS(=O)(=O)Cl.c1ccncc1>>CCCCCC(CCCNS(C)(=O)=O)OC1CCCCO1",
        "output": "493"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1cccc(Br)c1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.O.OCCO>>CC1(c2cccc(Br)c2)OCCO1",
        "output": "93"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)COC(=O)Cl.CN(C)C=O.CN1CCOCC1.Cl.NO.O=C(O)C(F)(F)F.O=C(O)C[C@@H](CCCC1CCCCC1)c1nc(C(=O)N2CC(N3CCOCC3)C2)no1>>O=C(C[C@@H](CCCC1CCCCC1)c1nc(C(=O)N2CC(N3CCOCC3)C2)no1)NO",
        "output": "480"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)CC(=O)c1cccc(-c2ccncc2)c1.CN(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1C(F)(F)F>>CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3ccncc3)c2)cc1C(F)(F)F",
        "output": "929"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCSc1ccc(S(C)(=O)=O)cc1C(=O)O.FC(F)(F)c1cnc(N2CCNCC2)nc1>>CCSc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ncc(C(F)(F)F)cn2)CC1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCOC(C)=O.N#CCCCc1ccc([N+](=O)[O-])cc1F.[Fe]>>N#CCCCc1ccc(N)cc1F",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.ClCCl.N.O=C(O)c1ccc2cncc(-c3ccc(Cl)cc3)c2c1.O=C(n1ccnc1)n1ccnc1>>NC(=O)c1ccc2cncc(-c3ccc(Cl)cc3)c2c1",
        "output": "358"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCCC[Sn+2]CCCC.CCOC(C)=O.CN=C=O.Cc1cc(O)cc(C)c1N=Cc1ccccc1O>>CNC(=O)Oc1cc(C)c(N=Cc2ccccc2O)c(C)c1",
        "output": "104"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOP(=O)(O)C(N1CCCC(C)(C)C1)P(=O)(O)O.Cl>>CC1(C)CCCN(C(P(=O)(O)O)P(=O)(O)O)C1",
        "output": "618"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "N#Cc1ccc(B(O)O)cc1.Nc1ccc2cccc(Oc3cc(Cl)ncn3)c2n1>>N#Cc1ccc(-c2cc(Oc3cccc4ccc(N)nc34)ncn2)cc1",
        "output": "884"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.CCOC(=O)c1cc2cc(OC)c(C)cc2[nH]1.ClCCl>>CCOC(=O)c1cc2cc(O)c(C)cc2[nH]1",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.ClCCl.OC1(c2ccc(Cl)cc2)CCNCC1>>CC(C)(C)OC(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1",
        "output": "694"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CO.COC(=O)c1ccc(Cl)nc1.Cl.O=C(NC1CCC(O)CC1)[C@H]1CCCNC1.O=C(O)C(F)(F)F>>COC(=O)c1ccc(N2CCC[C@H](C(=O)NC3CCC(O)CC3)C2)nc1",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(=O)Nc1ccc(C(=O)Cl)cc1.CCN(C(C)C)C(C)C.CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CN.ClCCl>>CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1ccc(NC(C)=O)cc1",
        "output": "271"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO[C@@H](Cc1ccc(OCc2nc(-c3ccccc3)oc2C)cc1C(F)(F)F)C(=O)OC.[Li+].[OH-]>>CCO[C@@H](Cc1ccc(OCc2nc(-c3ccccc3)oc2C)cc1C(F)(F)F)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COC(=O)c1cc2c([N+](=O)[O-])c(OC)ccc2n1C.O=C[O-].[NH4+].[Pd]>>COC(=O)c1cc2c(N)c(OC)ccc2n1C",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(-c2cnn(C)c2)cn2ncc(CN3CC4(CCN(C(=O)OC(C)(C)C)CC4)C3)c12.ClCCl.O=C(O)C(F)(F)F>>COc1cc(-c2cnn(C)c2)cn2ncc(CN3CC4(CCNCC4)C3)c12",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.O=c1[nH]cnc2cc(O)c(OCc3ccccc3)cc12.c1ccncc1>>CC(=O)Oc1cc2nc[nH]c(=O)c2cc1OCc1ccccc1",
        "output": "46"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Oc1ccc(OCc2ccccc2)c(C(C)(C)C)c1F.CCOC(C)=O.[Pd]>>CC(=O)Oc1ccc(O)c(C(C)(C)C)c1F",
        "output": "23"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(CCF)c1ccnc(N)c1.O=C(CBr)c1ccc2c(c1)OCO2>>CN(CCF)c1ccn2cc(-c3ccc4c(c3)OCO4)nc2c1",
        "output": "508"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "B.C1CCOC1.C1CCOC1.O=C(c1cc(F)c(Br)cc1Cl)N1CCCC1>>Fc1cc(CN2CCCC2)c(Cl)cc1Br",
        "output": "215"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)c1ccc(Cl)cc1.CCN(CC)CC.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.Clc1cccc(OCCBr)c1.NCC1CCNCC1.O>>NCC1CCN(CCOc2cccc(Cl)c2)CC1",
        "output": "73"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC1CC=CCC(OC(=O)/C=C/c2cn(C)cn2)Cc2ccccc2C1.O=C([O-])[O-].[K+].[K+]>>Cn1cnc(/C=C/C(=O)OC2CC=CCC(O)Cc3ccccc3C2)c1",
        "output": "325"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCC(C1CCC2(CC1)OCCO2)N(C)C.Cl>>CCC(C1CCC(=O)CC1)N(C)C",
        "output": "251"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.O=Cc1ccc(O)cc1.OCCCCCCBr.[K+].[OH-]>>O=Cc1ccc(OCCCCCCO)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.ClCc1ccccc1.N#Cc1ccc2[nH]ccc2c1.O.[H-].[Na+]>>N#Cc1ccc2c(ccn2Cc2ccccc2)c1",
        "output": "556"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc3c(c12)CCC(C(=O)O)C3.N#CC1CCCNC1>>CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc3c(c12)CCC(C(=O)N1CCCC(C#N)C1)C3",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCCCCCBr.CC#N.CCOCC.COC(=O)CCc1ccccc1O.O=C([O-])[O-].[K+].[K+]>>COC(=O)CCc1ccccc1OCCCCCBr",
        "output": "75"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C3(O)CN(C(=O)OC(C)(C)C)C3)n(C)c2n1.ClCCl.O=C(O)C(F)(F)F>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C3(O)CNC3)n(C)c2n1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C(=O)c1ccc(CCNC(=O)C(F)(F)F)cc1.CCO.Cl.[H][H].[Pd]>>CC(C)Cc1ccc(CCNC(=O)C(F)(F)F)cc1",
        "output": "92"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C[C@@H](N)c1ccccc1.O=C(O)c1ccc(-c2ccncc2)s1>>C[C@@H](NC(=O)c1ccc(-c2ccncc2)s1)c1ccccc1",
        "output": "950"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CNc1cc(C(=O)O)cc(Cl)n1.CO.Cl.O=S(Cl)Cl>>CNc1cc(C(=O)OC)cc(Cl)n1",
        "output": "33"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CNCC[C@H]1O[Si](C)(C)C(C)(C)C.CCN(CC)CC.CN(C)C=O.O=[N+]([O-])c1cnccc1Cl>>CC(C)(C)OC(=O)N[C@@H]1CN(c2ccncc2[N+](=O)[O-])CC[C@H]1O[Si](C)(C)C(C)(C)C",
        "output": "398"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)n1nc(-c2c(-c3ccccc3)nn3ccc(C(=O)O)cc23)ccc1=O.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl.NC1CC1.On1nnc2ccccc21>>CC(C)n1nc(-c2c(-c3ccccc3)nn3ccc(C(=O)NC4CC4)cc23)ccc1=O",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CCOCc1nc2c(N)nc3cc(OCCCCCCN)ccc3c2n1CC(C)(C)NC(C)=O.CS(=O)(=O)OS(C)(=O)=O>>CCOCc1nc2c(N)nc3cc(OCCCCCCNC(C)=O)ccc3c2n1CC(C)(C)NC(C)=O",
        "output": "45"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.Cc1cc(C)c(CN)c(O)n1.ClCCl.O>>Cc1cc(C)c(CNC(=O)OC(C)(C)C)c(O)n1",
        "output": "631"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COc1ccc(CCN)cc1OC.O=Cc1ccccc1.[BH4-].[Na+]>>COc1ccc(CCNCc2ccccc2)cc1OC",
        "output": "468"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN1CCN(Cc2ccc(-c3cc4c(CN)cccc4c(=O)[nH]3)cc2)CC1.CS(=O)(=O)Cl>>CN1CCN(Cc2ccc(-c3cc4c(CNS(C)(=O)=O)cccc4c(=O)[nH]3)cc2)CC1",
        "output": "742"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc(OC2CCCCO2)cc1.CC(=O)[O-].CC(=O)[O-].CCOC(C)=O.Cc1ccccc1.FC(F)(F)Oc1ccc(OC2CCNCC2)cc1.O.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>FC(F)(F)Oc1ccc(OC2CCN(c3ccc(OC4CCCCO4)cc3)CC2)cc1",
        "output": "294"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CN=C=S.C[C@@H]1[C@H](N)C[C@H]2C(C)(C)CCC[C@]2(C)[C@H]1C(=O)c1cc(O)cc(O)c1>>CNC(=S)N[C@@H]1C[C@H]2C(C)(C)CCC[C@]2(C)[C@@H](C(=O)c2cc(O)cc(O)c2)[C@@H]1C",
        "output": "79"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.COc1cc(CN)nc(SC)n1.[Na+].[OH-]>>COc1cc(CNC(C)=O)nc(SC)n1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCc1ccccc1.CCOC(C)=O.CCc1cc2c(OC)cccc2[nH]1.CN(C)C=O.O>>CCc1cc2c(OC)cccc2n1Cc1ccccc1",
        "output": "528"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNC1.CCCCC=O.COc1ccc([C@]23CCN[C@H]2C[C@H](NC(=S)NCc2ccccc2)CC3)cc1OC>>CCCCCN1CC[C@]2(c3ccc(OC)c(OC)c3)CC[C@@H](NC(=S)NCc3ccccc3)C[C@H]12",
        "output": "484"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CI.O=C([O-])[O-].Oc1ccc(Br)cc1OC(F)(F)F.[K+].[K+]>>COc1ccc(Br)cc1OC(F)(F)F",
        "output": "62"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(NC(=O)c2ccc(Cn3ccnn3)c3ccccc23)c(C(=O)NCC2CCC2)n1.Cl.O.c1ccncc1>>O=C(NCC1CCC1)c1nc(O)ccc1NC(=O)c1ccc(Cn2ccnn2)c2ccccc12",
        "output": "408"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CONC(=O)c1ccc(N2C[C@@H](CN=[N+]=[N-])OC2=O)cc1F.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CONC(=O)c1ccc(N2C[C@H](CN)OC2=O)cc1F",
        "output": "89"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.Cl.ClCCl.O=C1NCCC12CCCNC2.O=S(=O)(Cl)c1cc(F)cc(C(F)(F)F)c1>>O=C1NCCC12CCCN(S(=O)(=O)c1cc(F)cc(C(F)(F)F)c1)C2",
        "output": "99"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.COc1cc(C(C)=O)ccc1OCCCCl.O.c1ccc2c(C3CCNCC3)n[nH]c2c1>>COc1cc(C(C)=O)ccc1OCCCN1CCC(c2n[nH]c3ccccc23)CC1",
        "output": "138"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Nc1nc2cnc(N(c3cccc(NC(=O)OC(C)(C)C)c3)C3CC3)nc2s1.COc1ccccc1.O=C(O)C(F)(F)F>>CC(=O)Nc1nc2cnc(N(c3cccc(N)c3)C3CC3)nc2s1",
        "output": "782"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc2[nH]c(=O)c(C(=O)Nc3cc(C(=O)O)ccc3C)cc2cn1.NCc1ccc(Cl)cc1>>COc1cc2[nH]c(=O)c(C(=O)Nc3cc(C(=O)NCc4ccc(Cl)cc4)ccc3C)cc2cn1",
        "output": "753"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CNC(C)C.N#Cc1ccc(F)cc1Cl>>CC(C)N(C)c1ccc(C#N)c(Cl)c1",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(C(OC2CNC2)c2ccccc2C(F)(F)F)cc1.Cl.O=C=NC12CC3CC(CC(C3)C1)C2>>Cc1ccc(C(OC2CN(C(=O)NC34CC5CC(CC(C5)C3)C4)C2)c2ccccc2C(F)(F)F)cc1",
        "output": "437"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1O.[Na+].[OH-]>>CC(C)(C)OC(=O)Nc1ccc(C(=O)O)c(O)c1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.COc1c(F)ccc(F)c1O>>Oc1c(F)ccc(F)c1O",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrP(Br)Br.CS(=O)(=O)c1ccccc1CO.ClCCl.O=C([O-])O.[Na+]>>CS(=O)(=O)c1ccccc1CBr",
        "output": "300"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cl.N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3OCO4)CC2)CC1.O=C(O)CC1COCCO1>>O=C(CC1COCCO1)N[C@@H]1CC[C@@H](CCN2CCC(c3cccc4c3OCO4)CC2)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)C(C)(C)N1CCC(C#N)(c2ccc(NC(=O)c3cnn(-c4ccc(C(F)(F)F)cn4)c3C)cn2)CC1.CO.[BH4-].[BH4-].[Cl-].[Li+].[NH4+].[Na+]>>Cc1c(C(=O)Nc2ccc(C3(C#N)CCN(C(C)(C)CO)CC3)nc2)cnn1-c1ccc(C(F)(F)F)cn1",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1cc(C#N)ccc1Br.OB(O)c1ccccc1>>Cc1cc(C#N)ccc1-c1ccccc1",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc2nc(C)c(C)c(O)c2cc1C.O=P(Cl)(Cl)Cl>>COc1cc2nc(C)c(C)c(Cl)c2cc1C",
        "output": "177"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)CCN1CNC(=O)C12CCN(C1CCCCC1=O)CC2.O=C1NCN(c2ccccc2)C12CCN(C1CCCCC1O)CC2>>O=C1CCCCC1N1CCC2(CC1)C(=O)NCN2c1ccccc1",
        "output": "87"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1cn(C(=O)c2cc(Cl)ncn2)c2ccccc12.Cl.Cl.O=c1[nH]c2ncccc2n1C1CCNCC1>>Cc1cn(C(=O)c2cc(N3CCC(n4c(=O)[nH]c5ncccc54)CC3)ncn2)c2ccccc12",
        "output": "162"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.COc1ccc2c(c1)N(CCCCl)c1cccc(SC)c1S2.O=C([O-])O.OCCC1CCNCC1.[Na+]>>COc1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1cccc(SC)c1S2",
        "output": "138"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CO.COC(=O)c1csc2c(=O)cc(-c3ccccc3)oc12.O.[Na+].[OH-]>>O=C(O)c1csc2c(=O)cc(-c3ccccc3)oc12",
        "output": "152"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc(OC)c(F)c(N2Cc3cnc(S(C)=O)nc3N(C3CCCC3)C2=O)c1F.NCCOCCO>>COc1cc(OC)c(F)c(N2Cc3cnc(NCCOCCO)nc3N(C3CCCC3)C2=O)c1F",
        "output": "666"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1.O=C(O)c1ccnc2ccccc12.O=C1OCCN1P(=O)(Cl)N1CCOC1=O>>O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cn1cc(CCN)c2cc(Cl)ccc21.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(Cc2cccc(F)c2)cc1>>Cn1cc(CCNC(=O)c2ccc(Cc3cccc(F)c3)cc2)c2cc(Cl)ccc21",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.Cc1ccc(-c2c(CO)c(C)nc(CC(C)C)c2CNC(=O)OC(C)(C)C)cc1.O>>Cc1ccc(-c2c(COS(C)(=O)=O)c(C)nc(CC(C)C)c2CNC(=O)OC(C)(C)C)cc1",
        "output": "0"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCCCCCC.CCOC(C)=O.CN1CCNCC1.CO.COC(=O)c1ccc(-c2cc(N)n(-c3ccc(C(=O)O)cc3)n2)cc1.COC(C)(C)C.O.O=C(n1ccnc1)n1ccnc1>>COC(=O)c1ccc(-c2cc(N)n(-c3ccc(C(=O)N4CCN(C)CC4)cc3)n2)cc1",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.Cl.ClCCl.O=C1COC2(CCNCC2)CN1C1CC1.O=S(=O)(Cl)c1ccc(Br)c(F)c1>>O=C1COC2(CCN(S(=O)(=O)c3ccc(Br)c(F)c3)CC2)CN1C1CC1",
        "output": "99"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)c(F)c3)cc(S(C)(=O)=O)c2)c1CCC(=O)OCC.[Na+].[OH-]>>CS(=O)(=O)c1cc(OCCCCCCc2cccc(OCCCC(=O)O)c2CCC(=O)O)cc(-c2ccc(F)c(F)c2)c1",
        "output": "255"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.N#CC[C@H](O)c1ccccc1>>NCC[C@H](O)c1ccccc1",
        "output": "246"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.F[P-](F)(F)(F)(F)F.O.O=C(O)C1CCOCC1.Oc1ccccc1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>O=C(Oc1ccccc1)C1CCOCC1",
        "output": "108"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNCC1.C1CCOC1.O.O=[N+]([O-])c1ccc(CCl)cc1>>O=[N+]([O-])c1ccc(CN2CCCCC2)cc1",
        "output": "156"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN.CO.Fc1ccc(C2CCc3c(Cl)nc(Cl)nc32)c(F)c1>>CNc1nc(Cl)nc2c1CCC2c1ccc(F)cc1F",
        "output": "110"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)c1cn(CCC(F)Cn2cc(NC(=O)CN3CC(F)C3)nn2)nn1.ClCCl.O.O=C(O)C(F)(F)F>>O=C(CN1CC(F)C1)Nc1cn(CC(F)CCn2cc(C(=O)O)nn2)nn1",
        "output": "569"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc2nccc(Cl)c2cc1OC.CS(C)=O.Nc1ccc(O)cc1.O.O=C([O-])[O-].[Cs+].[Cs+]>>COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC",
        "output": "351"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.C[C@@](C#N)(N[C@@H](CO)c1ccccc1)C(F)(F)F.O.[Al+3].[H-].[H-].[H-].[H-].[K+].[Li+].[OH-]>>C[C@@](CN)(N[C@@H](CO)c1ccccc1)C(F)(F)F",
        "output": "246"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Cn1cc([N+](=O)[O-])c(C(N)=O)n1.[H][H].[Pd]>>Cn1cc(N)c(C(N)=O)n1",
        "output": "628"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1cnc(C=O)c(C)c1.NCc1ncccc1N1CCOCC1.[Na+]>>Cc1cnc(CNCc2ncccc2N2CCOCC2)c(C)c1",
        "output": "775"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)N.COc1cc(C(=O)O)ccc1B(O)O>>COc1cc(C(=O)NC(C)C)ccc1B(O)O",
        "output": "334"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)c1ccc(OCC2CC(OCc3ccccc3)CN2C(=O)OC(C)(C)C)c(OC)c1.[Pd]>>CCOC(=O)c1ccc(OCC2CC(O)CN2C(=O)OC(C)(C)C)c(OC)c1",
        "output": "178"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)COc1cccc2c1CCCCC2N.CCN(C(C)C)C(C)C.ClCCl.O=S(=O)(Cl)c1cccc(-c2ccccc2)c1>>CC(C)(C)OC(=O)COc1cccc2c1CCCCC2NS(=O)(=O)c1cccc(-c2ccccc2)c1",
        "output": "530"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)CCSCC(O)Cc1cccc(C2CCCC2)c1OCc1ccccc1.N>>NC(=O)CCSCC(O)Cc1cccc(C2CCCC2)c1OCc1ccccc1",
        "output": "432"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C=Cc1ccc(C)nc1.CN1CCCC1=O.COc1ccc(N2CCc3[nH]c4ccc(C)cc4c3C2)cc1.[K+].[OH-]>>COc1ccc(N2CCc3c(c4cc(C)ccc4n3CCc3ccc(C)nc3)C2)cc1",
        "output": "986"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "NCC1CCCO1.O=C1CCC2(CC1)OCCO2>>C1COC(CNC2CCC3(CC2)OCCO3)C1",
        "output": "236"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.COC(=O)CCCCl.O=C([O-])[O-].Oc1ccc(Nc2ccccc2)cc1.[K+].[K+]>>COC(=O)CCCOc1ccc(Nc2ccccc2)cc1",
        "output": "74"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrB(Br)Br.CCOC(=O)CCc1ccc(OC)cc1-c1c(C)noc1C.ClCCl>>CCOC(=O)CCc1ccc(O)cc1-c1c(C)noc1C",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4CC)n2)CCNC3)cc1.Clc1ncccn1>>CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4CC)n2)CCN(c2ncccn2)C3)cc1",
        "output": "36"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(CC)CC.N[C@H]1CC[C@H](O)CC1.O=C=Nc1cccc(C(F)(F)F)c1>>O=C(Nc1cccc(C(F)(F)F)c1)N[C@@H]1CC[C@@H](O)CC1",
        "output": "35"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1NCC2COCC12.CC(C)=O.ClCCCBr.O=C([O-])[O-].[K+].[K+]>>ClCCCN1CC2COCC2C1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCc1oc(-c2ccc(C(F)(F)F)cc2)cc1COc1ccc(C(=O)OC)cc1.CO.Cl.O.[Na+].[OH-]>>CCc1oc(-c2ccc(C(F)(F)F)cc2)cc1COc1ccc(C(=O)O)cc1",
        "output": "222"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2cc(F)c(C#N)cc2F)CC1.CCO.Cl.O.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCN(c2cc(F)c(C(=O)O)cc2F)CC1",
        "output": "445"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.Cl.Cl[Ti](Cl)(Cl)Cl.NC(=O)c1ccc(Oc2ccc3c(c2)CCC3=O)nc1.NCCC1CCCCC1.[BH3-]C#N.[Na+]>>NC(=O)c1ccc(Oc2ccc3c(c2)CCC3NCCC2CCCCC2)nc1",
        "output": "693"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@H]1C[C@H](N)C1.CS(C)=O.O=C([O-])[O-].O=[N+]([O-])c1cccnc1Cl.[K+].[K+]>>CC(C)(C)OC(=O)N[C@@H]1C[C@@H](Nc2ncccc2[N+](=O)[O-])C1",
        "output": "70"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(N3CCCC(C(=O)O)C3)nc2s1.CCN(C(C)C)C(C)C.CN(C)C=O.ClCCCl.On1nnc2ccccc21.[Cl-].[NH4+]>>CCCc1cc2c(N3CCn4c(nnc4C(F)(F)F)C3)nc(N3CCCC(C(N)=O)C3)nc2s1",
        "output": "313"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1>>CC(C)(C)OC(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=S",
        "output": "695"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.Cc1cc2c3c(c1)c1c(OCC#N)cccc1n3C(c1ccccc1)CO2>>Cc1cc2c3c(c1)c1c(OCCN)cccc1n3C(c1ccccc1)CO2",
        "output": "246"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.O.OC(CCl)CCc1cccnc1.Oc1ccc(-c2nccs2)cc1.[Na+].[OH-]>>OC(CCc1cccnc1)COc1ccc(-c2nccs2)cc1",
        "output": "74"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1c(F)cc(C(C)(C)C)c(O)c1C(=O)O.Cc1cc(S(=O)(=O)C(F)(F)F)ccc1N>>Cc1cc(S(=O)(=O)C(F)(F)F)ccc1NC(=O)c1c(C)c(F)cc(C(C)(C)C)c1O",
        "output": "50"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(=O)(=O)Cc1cccc(Nc2ncnc(-c3ccc(F)cc3F)n2)c1.C[C@@H](O)c1ccccc1>>C[C@@H](Oc1cc(F)ccc1-c1ncnc(Nc2cccc(CS(C)(=O)=O)c2)n1)c1ccccc1",
        "output": "485"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCN.ClCCl.O=S(=O)(Cl)CCCOc1ccc2c(c1)C(C1(c3ccc(Cl)cc3)CCC1)=NCC2>>CCCNS(=O)(=O)CCCOc1ccc2c(c1)C(C1(c3ccc(Cl)cc3)CCC1)=NCC2",
        "output": "493"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)CCSCc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccn2)c1.O.O.[Li+].[OH-]>>O=C(O)CCSCc1cccc(C(=O)Nc2ccc(N3CCCCC3)cc2-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccn2)c1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)=O.CCOC(C)=O.COc1cccc(Cn2c(=O)oc3ccc(C4OCCO4)cc32)c1.Cc1ccc(S(=O)(=O)O)cc1.O.O.[Cl-].[Na+]>>COc1cccc(Cn2c(=O)oc3ccc(C=O)cc32)c1",
        "output": "655"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cl.N#Cc1cc(C(=O)CNC2CCCC2)cc(C#N)c1N>>N#Cc1cc(C(O)CNC2CCCC2)cc(C#N)c1N",
        "output": "24"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.O=C(CCc1c[nH]c2c1CCCC2)N1CCOCC1.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>c1[nH]c2c(c1CCCN1CCOCC1)CCCC2",
        "output": "112"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO/N=C(\\COc1ccc(CO)cc1)c1ccccc1.COC(=O)CC(c1ccc(O)cc1)c1ccon1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CO/N=C(\\COc1ccc(COc2ccc(C(CC(=O)OC)c3ccon3)cc2)cc1)c1ccccc1",
        "output": "347"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.Cc1ccc(=O)n(CCCCBr)n1.ClCCl.O.O=C([O-])[O-].[K+].[K+].c1ccc2c(N3CCNCC3)cccc2c1>>Cc1ccc(=O)n(CCCCN2CCN(c3cccc4ccccc34)CC2)n1",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1cc([N+](=O)[O-])ccc1Cl.CCOC(C)=O>>CC(C)(C)c1cc(N)ccc1Cl",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)=O.CCO.CCOC(=O)CN1C2CC(=O)CC1CC(C(=O)OCC)C2.CC[O-].CS(=O)(=O)O.C[O-].Cl.[BH4-].[Na+].[Na+].[Na+]>>CCOC(=O)CN1C2CC(O)CC1CC(C(=O)OCC)C2",
        "output": "91"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)CCCCOc1cc2c(cc1N)nc(-c1ccccc1)n2-c1ccc(OC)cc1.O=S(=O)(Cl)c1ccc(Cl)cc1>>COC(=O)CCCCOc1cc2c(cc1NS(=O)(=O)c1ccc(Cl)cc1)nc(-c1ccccc1)n2-c1ccc(OC)cc1",
        "output": "68"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCOc1nc(N)c2nc(OC)n(CCCCCCCl)c2n1.CCN(C(C)C)C(C)C.CN(C)C=O.CN1CCNCC1.[I-].[Na+]>>CCCCOc1nc(N)c2nc(OC)n(CCCCCCN3CCN(C)CC3)c2n1",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.OCCc1ccc(Cl)cc1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCCc2ccc(Cl)cc2)cc1",
        "output": "197"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CN(C)CC(=O)Nc1cccc(C(F)(F)F)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CN(C)CCNc1cccc(C(F)(F)F)c1",
        "output": "112"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCO.CN(C)C(On1nnc2ccccc21)=[N+](C)C.ClBr.ClCCl.F[B-](F)(F)F.N[C@@H](COCc1ccccc1)c1nc2cc(Cl)ccc2[nH]1.O=C(O)c1ccc(C(=O)N2CC=CC2)c(Br)c1>>O=C(N[C@@H](COCc1ccccc1)c1nc2cc(Cl)ccc2[nH]1)c1ccc(C(=O)N2CC=CC2)c(Br)c1",
        "output": "902"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.CO.COCOc1c(OC)cc(CCC(=O)c2c(OC)cc(OC)c(CCC(C)C)c2OCC(=O)OC)cc1OC.Cl>>COC(=O)COc1c(CCC(C)C)c(OC)cc(OC)c1C(=O)CCc1cc(OC)c(O)c(OC)c1",
        "output": "755"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CS(=O)(=O)Cc1cccc([N+](=O)[O-])c1.Cl.[Cl-].[Cl-].[Cl-].[Na+].[OH-].[Ti+3]>>CS(=O)(=O)Cc1cccc(N)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrP(Br)Br.C1CCOC1.CCOC(C)=O.CCOCC.O=C([O-])O.OCc1ccnc(-n2cccn2)c1.[Na+]>>BrCc1ccnc(-n2cccn2)c1",
        "output": "300"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)NCCN.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.F[P-](F)(F)(F)(F)F.O=C(O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1>>CC(C)(C)OC(=O)NCCNC(=O)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1",
        "output": "230"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)CC1NC(C(=O)NCCCN)C(c2cccc(Cl)c2)C1(C#N)c1ccc(Cl)cc1.CN(C)c1ccccn1.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)CC1NC(C(=O)NCCCNS(C)(=O)=O)C(c2cccc(Cl)c2)C1(C#N)c1ccc(Cl)cc1",
        "output": "493"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC1(C)O[C@@H]2[C@H](O1)[C@@H](CNCCCN1C(=O)c3ccccc3C1=O)O[C@H]2n1cnc2c(N)ncnc21.CC=O.ClCCCl.O=C([O-])O.[Na+].[Na+]>>CCN(CCCN1C(=O)c2ccccc2C1=O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H]2OC(C)(C)O[C@H]12",
        "output": "484"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.COC(=O)C(N)Cc1ccc(O)cc1.ClCCl.O=C(O)CCc1ccc(O)cc1>>COC(=O)C(Cc1ccc(O)cc1)NC(=O)CCc1ccc(O)cc1",
        "output": "129"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1onc(-c2ccccc2)c1-c1nnc(-c2ccc(Cl)nc2)o1.OC1CCNCC1>>Cc1onc(-c2ccccc2)c1-c1nnc(-c2ccc(N3CCC(O)CC3)nc2)o1",
        "output": "220"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.ClCCl.O=C(COCc1ccc(F)cc1)NCCCc1ccc(CCO)cc1>>O=CCc1ccc(CCCNC(=O)COCc2ccc(F)cc2)cc1",
        "output": "142"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCCC(CO)C1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)N1CCCC(COS(C)(=O)=O)C1",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)OC[C@@H]1CC[C@H](CO[Si](C)(C)C(C)(C)C)N1c1nc(-c2ccc([N+](=O)[O-])cc2)nc(N2CC3CCC(C2)O3)n1.[H][H].[Pd]>>CC(C)(C)[Si](C)(C)OC[C@@H]1CC[C@H](CO[Si](C)(C)C(C)(C)C)N1c1nc(-c2ccc(N)cc2)nc(N2CC3CCC(C2)O3)n1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=C(C)C(C(=O)O)N1C(=O)C(NC(=O)Cc2ccccc2)C1SN1C(=O)c2ccccc2C1=O.C=[N+]=[N-].CCOCC>>C=C(C)C(C(=O)OC)N1C(=O)C(NC(=O)Cc2ccccc2)C1SN1C(=O)c2ccccc2C1=O",
        "output": "60"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Nc1ccc(O)cc1.CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc2ncccc2c1CBr.[Cs+].[Cs+]>>CC(=O)Nc1ccc(OCc2c([N+](=O)[O-])ccc3ncccc23)cc1",
        "output": "127"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.ClCCl.N#Cc1ccc(C(=O)O)c(F)c1.O=C(Cl)C(=O)Cl>>N#Cc1ccc(C(=O)Cl)c(F)c1",
        "output": "448"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1cc(O)c2cc(Br)cc(OCc3ccccc3)c2n1.COc1ccc(B(O)O)cc1.Cc1cccc(B(O)O)c1>>COC(=O)c1cc(O)c2cc(-c3cccc(C)c3)cc(OCc3ccccc3)c2n1",
        "output": "837"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1ccc(C(C)(C)C#N)cc1.ClCCl>>CC(C)(C#N)c1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCS(=O)(=O)Cl.Cc1ccccc1.ClCCl.FC(F)(F)c1nnc2ccc(N3CC4CNCC4C3)nn12>>CCS(=O)(=O)N1CC2CN(c3ccc4nnc(C(F)(F)F)n4n3)CC2C1",
        "output": "584"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CC(=O)Cl.CCCCCC.CO.ClCCl.O.OCCc1ccccc1.c1ccncc1>>C=CC(=O)OCCc1ccccc1",
        "output": "320"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1c2cc(Cl)nc(=O)n2CC1(C)C.OCCc1cccc(F)c1F>>CN1c2cc(OCCc3cccc(F)c3F)nc(=O)n2CC1(C)C",
        "output": "653"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=CC(=O)O.CCCc1c(CNC)ccc2ccccc12.CN1CC(=O)Nc2ncc(/C=C/C(=O)O)cc2C1.CNCc1cn(C)c2ccccc12.Cl>>C=CC(=O)N(C)Cc1cn(C)c2ccccc12",
        "output": "517"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1cc(O)c2c(Cl)cc(Cl)c(O)c2n1.COC(=O)c1cc(O)c2cccc(OCc3ccccc3)c2n1>>O=C(O)c1cc(O)c2c(Cl)cc(Cl)c(O)c2n1",
        "output": "152"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Nc1ncc(Br)nc1C(=O)Nc1cnccc1CCN1CCCC1.OB(O)c1ccc(F)c(Cl)c1>>Nc1ncc(-c2ccc(F)c(Cl)c2)nc1C(=O)Nc1cnccc1CCN1CCCC1",
        "output": "876"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)c1sc2c(c1C)CC(C)(C)CC2.[Li+].[OH-]>>Cc1c(C(=O)O)sc2c1CC(C)(C)CC2",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "N#Cc1cnc2cnc(F)cc2c1Nc1ccc2[nH]ccc2c1.NCCN1CCOCC1>>N#Cc1cnc2cnc(NCCN3CCOCC3)cc2c1Nc1ccc2[nH]ccc2c1",
        "output": "810"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cc1cccc2cc[nH]c12.O.[H-].[Na+]>>Cc1cccc2ccn(C(=O)OC(C)(C)C)c12",
        "output": "748"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CN1C(=O)C(c2ccc(Cl)cc2)=NC12CCCCC2.CO.O.[Na+].[OH-]>>O=C(O)CN1C(=O)C(c2ccc(Cl)cc2)=NC12CCCCC2",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COCCOCCN(CCOCCOC)CCOCCOC.Cl[Cu].FC(F)(F)c1ccccc1I.O.O=C1CCCc2cc(O)ccc21.[H-].[Na+]>>O=C1CCCc2cc(Oc3ccccc3C(F)(F)F)ccc21",
        "output": "382"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(=O)C1(Cc2ccc(Cl)cc2)CCCNC1.Cl.ClCc1ccccc1.O=C([O-])O.[Na+]>>CC(=O)C1(Cc2ccc(Cl)cc2)CCCN(Cc2ccccc2)C1",
        "output": "156"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1ccc2c(c1)Cc1cccc(-c3cc(=O)cc(N4CCOCC4)o3)c1S2.ClCCl.O=C(O)C(F)(F)F>>Nc1ccc2c(c1)Cc1cccc(-c3cc(=O)cc(N4CCOCC4)o3)c1S2",
        "output": "782"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1c(C(C)(C)C)cc(-c2cccc(C3CCN(C(=O)OC(C)(C)C)CC3)n2)cc1C(C)(C)C.Cc1ccccc1.ClCCl.O=C(O)C(F)(F)F>>COc1c(C(C)(C)C)cc(-c2cccc(C3CCNCC3)n2)cc1C(C)(C)C",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CCC(CC=C)(CC=C)C(=O)Cl.C[C@H]1C=CC2=C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O)[C@@H]2[C@H]1CC[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CC(=O)O1>>C=CCC(CC=C)(CC=C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O[Si](C)(C)C(C)(C)C)CC(=O)O3)[C@H]21",
        "output": "126"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCBr.O=c1[nH]c2ccc3ncccc3c2[nH]1.[H-].[Na+]>>CCn1c(=O)[nH]c2c3cccnc3ccc21",
        "output": "276"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=Cc1cnc(Nc2ccc(S(=O)(=O)N3CCN(C(=O)OC(C)(C)C)CC3)cc2)cn1.CC(=O)[O-].CC(=O)[O-].CCN(C(C)C)C(C)C.CN(C)C=O.Cc1ccc(P(c2ccc(C)cc2)c2ccc(C)cc2)cc1.Oc1cccc(I)c1.[Pd+2]>>CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccc(Nc3cnc(/C=C/c4cccc(O)c4)cn3)cc2)CC1",
        "output": "725"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.O=[N+]([O-])c1ccc(-c2cnccc2-c2ccccc2)cc1.[Pd]>>Nc1ccc(-c2cnccc2-c2ccccc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)Oc1ccc(-c2ccc(-c3cccc4c3CC[C@H]4NC(=O)OC(C)(C)C)s2)cc1C#N.Cl>>CC(C)Oc1ccc(-c2ccc(-c3cccc4c3CC[C@H]4N)s2)cc1C#N",
        "output": "793"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCCC1=O.COc1c(C)ccc2c1C[C@@H](C1CCNCC1)O[C@H]2CBr.FC(F)(F)c1ccc(CBr)cc1>>COc1c(C)ccc2c1C[C@@H](C1CCN(Cc3ccc(C(F)(F)F)cc3)CC1)O[C@H]2CBr",
        "output": "248"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(O)c1ccc(F)c(C#N)c1.O.[Na+].[OH-]>>CC(O)c1ccc(F)c(C(=O)O)c1",
        "output": "445"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CNC(=O)CC(c1cccnc1)c1ccc2c(OC)n[nH]c2c1.CNCCC(c1ccccc1)c1cccc2cc[nH]c12.O=C(O)C(F)(F)F>>CNCCC(c1cccnc1)c1ccc2c(OC)n[nH]c2c1",
        "output": "112"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.COc1cc2c(O)c(C#N)cnc2c(OC)c1OC.O=P(Cl)(Cl)Cl>>COc1cc2c(Cl)c(C#N)cnc2c(OC)c1OC",
        "output": "177"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)I.CN(C)C=O.O=C([O-])[O-].O=Cc1cc(Br)c(-c2ccc(F)cc2)c(F)c1O.[K+].[K+]>>CC(C)Oc1c(C=O)cc(Br)c(-c2ccc(F)cc2)c1F",
        "output": "318"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.CO.COc1cc2c(cc1F)C(C)(C)CC2.ClCCl.O=C([O-])O.[Na+]>>CC1(C)CCc2cc(O)c(F)cc21",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CCN(CC)CCNc1ccc2ncn3c4ccc(O)cc4c(=O)c1c23.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.CO.Cl.Cl.Cl.ClC(Cl)Cl.O>>CCN(CC)CCNc1ccc2ncn3c4ccc(OC(C)=O)cc4c(=O)c1c23",
        "output": "108"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)CNC(=O)c1c(O)ccc2nc(-c3nccs3)c(-c3ccccc3)nc12.[Na+].[OH-]>>O=C(O)CNC(=O)c1c(O)ccc2nc(-c3nccs3)c(-c3ccccc3)nc12",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)n1cnc2c([N+](=O)[O-])cccc21.CO.[Pd]>>CC(C)(C)OC(=O)n1cnc2c(N)cccc21",
        "output": "269"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "ClCCl.Cn1cc(Nc2ncc3cnn(C4CCCN(C(=O)OC(C)(C)C)C4)c3n2)cn1.O=C(O)C(F)(F)F>>Cn1cc(Nc2ncc3cnn(C4CCCNC4)c3n2)cn1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.O=[N+]([O-])CC(O)C1CCCO1.[Pd]>>NCC(O)C1CCCO1",
        "output": "226"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=N)NO.O=C(O)C1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)N2CCSC2)C1>>Cc1noc(C2CC(c3ccc(C(F)(F)F)cc3)CN(C(=O)N3CCSC3)C2)n1",
        "output": "924"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CI.CN(C)C=O.Fc1ccc2cc[nH]c2c1.[H-].[Na+]>>Cn1ccc2ccc(F)cc21",
        "output": "191"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CO.Cl.NO.O.O=C(Cc1ccc(Cl)cn1)c1ccc(F)cc1.[Na+]>>ON=C(Cc1ccc(Cl)cn1)c1ccc(F)cc1",
        "output": "212"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.COC(=O)c1cn(-c2ccnc(Cl)n2)nc1-c1ccccc1Cl.ClCCl.NCCc1ccc(O)cc1>>COC(=O)c1cn(-c2ccnc(NCCc3ccc(O)cc3)n2)nc1-c1ccccc1Cl",
        "output": "544"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.O.O=S(=O)(Cl)c1ccccc1.O=[N+]([O-])c1ccc2[nH]ccc2c1.[H-].[Na+]>>O=[N+]([O-])c1ccc2c(ccn2S(=O)(=O)c2ccccc2)c1",
        "output": "648"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.Fc1ccc2c(C3CCNCC3)noc2c1.O=C([O-])[O-].OCCCBr.[K+].[K+]>>OCCCN1CCC(c2noc3cc(F)ccc23)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.CC(C)n1nc(I)cc1C1CCNCC1.CO.O.O=C1COC1.[BH3-]C#N.[Na+]>>CC(C)n1nc(I)cc1C1CCN(C2COC2)CC1",
        "output": "983"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)OC(C)=O.CCCCCC1C(=O)C=CC1(C)O.CCN(CC)CC>>CCCCCC1C(=O)C=CC1(C)OC(C)=O",
        "output": "155"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)Cl.CN(C)C=O.Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O.c1ccncc1>>CC(=O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@@H](O)[C@@H]1O",
        "output": "126"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=C(O)c1ccc(Br)c(S(=O)(=O)Cl)c1.O=S(Cl)Cl>>COC(=O)c1ccc(Br)c(S(=O)(=O)Cl)c1",
        "output": "33"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCOc1ccc(C(=O)O)c(N)c1.CO.COC(C)(C)C.O=S(Cl)Cl>>CCCCOc1ccc(C(=O)OC)c(N)c1",
        "output": "195"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)c1ccncc1.CS(=O)(=O)Cl.Nc1cc(Br)cc(-c2nc3ccccc3o2)c1.c1ccncc1>>CS(=O)(=O)Nc1cc(Br)cc(-c2nc3ccccc3o2)c1",
        "output": "194"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COc1cc2c(cc1Br)-c1cc3c(n1CC2)C(=O)N(C(C)(C)C)CCC3.O.O=C1CCC(=O)N1Br>>COc1cc2c(cc1Br)-c1c(Br)c3c(n1CC2)C(=O)N(C(C)(C)C)CCC3",
        "output": "796"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCc2nc3ccnn3c(N3CC[C@H]3CO)c2CC1.CCOC(C)=O.CI.[H-].[Na+]>>COC[C@@H]1CCN1c1c2c(nc3ccnn13)CCN(C(=O)OC(C)(C)C)CC2",
        "output": "140"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC(=O)O)C(=O)c1ccc2c(c1)c1c(n2C)CCC(C2CCOCC2)C1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@H](O)CN.F[P-](F)(F)(F)(F)F>>CCN(CC(=O)NC[C@H](C)O)C(=O)c1ccc2c(c1)c1c(n2C)CCC(C2CCOCC2)C1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NCCCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1.O=C(Cl)C(=O)Cl.O=C(O)C=Cc1cccnc1>>O=C(C=Cc1cccnc1)NCCCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1",
        "output": "549"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.COC(=O)[C@]1(CCCO)CCCN1C(=O)OCc1ccccc1.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl>>COC(=O)[C@]1(CCC=O)CCCN1C(=O)OCc1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCc1ccccc1.Cc1cccc(Cn2ccc(N3C(=O)c4ccccc4C3=O)n2)c1F.O=C1c2ccccc2C(=O)N1c1cc[nH]n1>>O=C1c2ccccc2C(=O)N1c1ccn(Cc2ccccc2)n1",
        "output": "635"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC1(C)CN(C(=O)CCOc2ccc(Cl)cc2NC(N)=O)CCC1(O)Cc1ccc(F)cc1.CO>>CC1(C)CN(CCCOc2ccc(Cl)cc2NC(N)=O)CCC1(O)Cc1ccc(F)cc1",
        "output": "112"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1nc(OCC(=O)N(C)C2CCNCC2)nc(C)c1NC(=O)OC(C)(C)C.O=C1CCCCC1.[Na+]>>Cc1nc(OCC(=O)N(C)C2CCN(C3CCCCC3)CC2)nc(C)c1NC(=O)OC(C)(C)C",
        "output": "187"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)N=C=O.CO.ClCCl.NCCN1CCC(CNC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1>>CC(C)(C)NC(=O)NCCN1CCC(CNC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1",
        "output": "244"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.Cc1cc(Br)cc(F)c1C(=O)O.N.O=C(n1ccnc1)n1ccnc1>>Cc1cc(Br)cc(F)c1C(N)=O",
        "output": "358"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1=c2ccccc2=C(c2cccc3ccccc23)C(P(c2ccccc2)c2ccccc2)(P(c2ccccc2)c2ccccc2)C1.C1CCNCC1.C1COCCO1.CC(C)(C)O.CC(C)(C)[O-].Cc1nc2ccc(Br)cc2c(-c2ccc(F)cc2)c1C(=O)OC(C)(C)C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[K+].[Pd].[Pd]>>Cc1nc2ccc(N3CCCCC3)cc2c(-c2ccc(F)cc2)c1C(=O)OC(C)(C)C",
        "output": "294"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.O=C1CCOc2ccccc21.[BH4-].[Na+]>>OC1CCOc2ccccc21",
        "output": "24"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.Cc1cc(Nc2cc(NC(=O)c3c(Cl)cccc3Cl)c([N+](=O)[O-])cn2)nc(C)n1.[Pd]>>Cc1cc(Nc2cc(NC(=O)c3c(Cl)cccc3Cl)c(N)cn2)nc(C)n1",
        "output": "269"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CO.O=C(Cl)C(=O)Cl.O=C(O)[C@H]1CCCN(C(=O)OCc2ccccc2)C1>>O=C(Cl)[C@H]1CCCN(C(=O)OCc2ccccc2)C1",
        "output": "56"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1cn(C2CCCCC2)c2nc(S(C)(=O)=O)ncc2c1=O.COCCCN>>CCOC(=O)c1cn(C2CCCCC2)c2nc(NCCCOC)ncc2c1=O",
        "output": "629"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#CCCc1cnc2ccccc2n1.FCc1cccc(Br)n1>>FCc1cccc(C#CCCc2cnc3ccccc3n2)n1",
        "output": "777"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCc2cc(N3CCCCCC3=O)ccc21.Cl.O=C(Cl)CCCCCBr>>O=C1CCCCCN1c1ccc2c(c1)CCN2",
        "output": "830"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)=O.ClCCCl.[Na+].c1cnc2c(c1)CCCC2NCc1nc2ccccc2[nH]1>>CC(C)N(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21",
        "output": "187"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=O.O=C([O-])[O-].O=C1c2ccccc2C(=O)N1CCCBr.OCCN1CCNCC1.[K+].[K+]>>O=C1c2ccccc2C(=O)N1CCCN1CCN(CCO)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)C(F)(F)CNc1nccc(Nc2cc3c(cn2)nc(C)n3C(C)C)n1.O.O.[Li+].[OH-]>>Cc1nc2cnc(Nc3ccnc(NCC(F)(F)C(=O)O)n3)cc2n1C(C)C",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.Cl.O=C(O)c1ccc(-c2c[nH]cn2)cc1.O=S(Cl)Cl>>COC(=O)c1ccc(-c2c[nH]cn2)cc1",
        "output": "33"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C(C#N)=NOC(N1CCOCC1)=[N+](C)C.CCn1cc(C(=O)O)c(=O)c(-c2ccccc2)c1.CN(C)C=O.COc1ccc(-c2cnc(N)c(-c3ccc(N)cc3)c2)cc1OC.F[P-](F)(F)(F)(F)F.O>>CCn1cc(C(=O)Nc2ccc(-c3cc(-c4ccc(OC)c(OC)c4)cnc3N)cc2)c(=O)c(-c2ccccc2)c1",
        "output": "739"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(=O)Cl.COc1ccc(OCC2CC2)c(-c2ncnc3c(C(=O)N[C@@H]4CCNC4)c(C)[nH]c23)c1.Cl>>CCC(=O)N1CC[C@@H](NC(=O)c2c(C)[nH]c3c(-c4cc(OC)ccc4OCC4CC4)ncnc23)C1",
        "output": "125"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2nc(-c3ccc(Cl)cc3Cl)cs2)CC1.CCOC(C)=O.Cl>>Clc1ccc(-c2csc(N3CCNCC3)n2)c(Cl)c1",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CCS(C)(=O)=O)C(=O)O.CCOC(=O)C(C#N)=NOC(N(C)C)=[N+](C)C.CCOC(=O)N1CCNCC1.CN(C)C=O.F[B-](F)(F)F.O=C([O-])O.[Na+]>>CCOC(=O)N1CCN(C(=O)[C@H](CCS(C)(=O)=O)NC(=O)OC(C)(C)C)CC1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1cc(C(=O)N(Cc2cc3ccccc3cn2)C[C@@H]2CCCN2)cc2c1OC(C)(C)O2.ClCCl.O=C1CCC1.[Na+]>>COc1cc(C(=O)N(Cc2cc3ccccc3cn2)C[C@@H]2CCCN2C2CCC2)cc2c1OC(C)(C)O2",
        "output": "187"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Nc1cccc([N+](=O)[O-])c1.O=C(O)Cc1ccccc1Br>>O=C(O)Cc1ccccc1Nc1cccc([N+](=O)[O-])c1",
        "output": "405"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cc2c([N+](=O)[O-])cccc2n1Cc1ccc(Cl)c(Cl)c1.[Cl-].[Cl-].[Cl-].[Na+].[OH-].[Ti+3]>>CCOC(=O)c1cc2c(N)cccc2n1Cc1ccc(Cl)c(Cl)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCNC(=O)Nc1ccc(Oc2ccnc3cc(O)c(OC)cc23)cc1Cl.CN(C)C=O.Cl.ClCc1cccnc1.O.O=C([O-])[O-].[K+].[K+]>>CCCNC(=O)Nc1ccc(Oc2ccnc3cc(OCc4cccnc4)c(OC)cc23)cc1Cl",
        "output": "678"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)ON=O.CN(C)C=O.Cc1cc([N+](=O)[O-])c(C)c([N+](=O)[O-])c1N>>Cc1cc([N+](=O)[O-])c(C)c([N+](=O)[O-])c1",
        "output": "324"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CCOC(=O)CNC(=O)c1c(O)c(-c2ccc(F)c(F)c2)cc2nc(-c3ccc(F)c(F)c3)cnc12.[Na+].[OH-]>>O=C(O)CNC(=O)c1c(O)c(-c2ccc(F)c(F)c2)cc2nc(-c3ccc(F)c(F)c3)cnc12",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.O.O=[N+]([O-])c1ccc2c(cnn2CCN2CCOCC2)c1.[Cl-].[Fe].[NH4+]>>Nc1ccc2c(cnn2CCN2CCOCC2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)CCN(C1(C(=O)NO)CCCC1)S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1.Cc1ccccc1.ClCCl.O.[Na+].[OH-]>>O=C(O)CCN(C1(C(=O)NO)CCCC1)S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(-c2ccc(O)cc2)cc1.CN(C)C=O.COC(=O)CBr.O=C([O-])[O-].[K+].[K+]>>COC(=O)COc1ccc(-c2ccc(CNC(=O)OC(C)(C)C)cc2)cc1",
        "output": "557"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#Cc1ccc(-c2ccc(Cl)cc2)cn1.O=[N+]([O-])c1cc(I)ccc1OCCN1CCCC1>>O=[N+]([O-])c1cc(C#Cc2ccc(-c3ccc(Cl)cc3)cn2)ccc1OCCN1CCCC1",
        "output": "664"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)CCCBr.CCOC(=O)Cc1ccc(N)cc1.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CCCNc1ccc(CC(=O)OCC)cc1",
        "output": "273"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.O=C1CCC(=O)N1I.O=C1CCC(=O)N1I.O=S(=O)(O)O.Oc1ccc(C(F)(F)F)cc1>>Oc1ccc(C(F)(F)F)cc1I",
        "output": "834"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1ccc(NC(=O)OC(C)(C)C)c([N+](=O)[O-])c1.[Pd]>>CC(C)c1ccc(NC(=O)OC(C)(C)C)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.Cl.ClCCCl.ClCCl.NCCN1CCOCC1.O=C(O)C=C1c2ccccc2-c2ccccc21.On1nnc2ccccc21>>O=C(C=C1c2ccccc2-c2ccccc21)NCCN1CCOCC1",
        "output": "549"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)CC(Cl)CC1=O.CCO.O=Cc1ccc(F)cc1.[Na+].[OH-]>>CC1(C)CC(Cl)C(=Cc2ccc(F)cc2)C1=O",
        "output": "85"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)c1nn(-c2ccc(C#N)cc2[N+](=O)[O-])c2cccc(-n3cnc(-c4cccnc4)c3)c12.CO.O.[Cl-].[Fe].[NH4+]>>CC(C)c1nn(-c2ccc(C#N)cc2N)c2cccc(-n3cnc(-c4cccnc4)c3)c12",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC1(CCO)CC(=O)c2cc(Br)c(F)cc2O1.CCN(CC)CC.COCCl.ClCCl>>COCOCCC1(C)CC(=O)c2cc(Br)c(F)cc2O1",
        "output": "598"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(C)Cc1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1.CO.Cl.[Na+].[OH-]>>CC(Cc1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCOC(=O)c1c(C)c(C(=O)c2ccc(N)c(OC)c2)n2ccccc12.[Na+].[OH-]>>COc1cc(C(=O)c2c(C)c(C(=O)O)c3ccccn23)ccc1N",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.COC(=O)c1cccc(Cn2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c32)c1.Cl.O.[Na+].[OH-]>>O=C(O)c1cccc(Cn2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c32)c1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1ccc2c(c1)Cc1cc(N)ccc1-2.CCCC(=O)Cl.CCN(CC)CC.ClCCl>>CCCC(=O)Nc1ccc2c(c1)Cc1cc(NC(=O)OC(C)(C)C)ccc1-2",
        "output": "9"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.CCCCCC.CCOC(=O)CCCCCO.O=P(O)(O)O>>CCOC(=O)CCCCCOC(C)=O",
        "output": "254"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cccc(-c2ccco2)n1.ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1>>Cc1cccc(-c2ccco2)[n+]1[O-]",
        "output": "262"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(C)CC(N2C(=O)c3ccc(C(=O)O)cc3C2=O)CC(C)(C)N1.CCCCBr.CCCCC.CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC.CN(C)C=O.COC(C)(C)C.ClC(Cl)Cl.O.O=C([O-])[O-].[Cl-].[Na+].[Na+]>>CCCCOC(=O)c1ccc2c(c1)C(=O)N(C1CC(C)(C)NC(C)(C)C1)C2=O",
        "output": "416"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COc1cccc(C2(O)CCN(CC(=O)c3ccc4c(c3)CCC(=O)N4)CC2)c1.[BH4-].[Na+]>>COc1cccc(C2(O)CCN(CC(O)c3ccc4c(c3)CCC(=O)N4)CC2)c1",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.[OH-].[OH-].[Pd+2].c1ccc(CN2CCC(c3ccccn3)CC2)cc1>>c1ccc(C2CCNCC2)nc1",
        "output": "84"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCO[C@@H](Cc1ccc(-c2cccc(CN(C)C(=O)c3ccc(-c4ccccc4)cc3)c2)cc1)C(=O)OC.CO.O.O.[Li+].[OH-]>>CCO[C@@H](Cc1ccc(-c2cccc(CN(C)C(=O)c3ccc(-c4ccccc4)cc3)c2)cc1)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN(C)c1ccc(C#N)c(Cl)c1.II.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CN(C)c1ccc(CN)c(Cl)c1",
        "output": "175"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1ccc(C(C)O)cc1F.ClCCl.O=[Cr](=O)([O-])Cl.c1cc[nH+]cc1>>CC(=O)c1ccc(C)c(F)c1",
        "output": "32"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CO.F[B-](F)(F)F.NC(=N[N+](=O)[O-])NCCC[C@@H](NC(=O)OCc1ccc2ccccc2c1)C(=O)O.NCc1ccc(CNC(N)=O)cc1>>NC(=O)NCc1ccc(CNC(=O)[C@@H](CCCNC(N)=N[N+](=O)[O-])NC(=O)OCc2ccc3ccccc3c2)cc1",
        "output": "599"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CCN(CC1CCCC1)c1ncc(C(=O)O)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1.CCN=C=NCCCN(C)C.CN.CN(C)C=O.Cl.Cl.Oc1ccnc2[nH]nnc12>>CCN(CC1CCCC1)c1ncc(C(=O)NC)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1",
        "output": "674"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.C[O-].Oc1ccc(Cl)nc1Br.[Na+]>>COc1ccc(O)c(Br)n1",
        "output": "433"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1ccn(S(=O)(=O)c2ccc3c(c2)nc(C(C)(C)C)n3CC2CCOCC2)c1.O.[Li+].[OH-]>>CC(C)(C)c1nc2cc(S(=O)(=O)n3ccc(C(=O)O)c3)ccc2n1CC1CCOCC1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC#Cc1cc(C[C@H](NC(=O)OC(C)(C)C)[C@H]2CN(C3(c4cccc(C(C)(C)C)c4)CC3)C(=O)O2)ccc1NC(=O)C(F)(F)F.CCCCCC.CCOC(C)=O.CCOC(C)=O.N.[Pd]>>CCCCCc1cc(C[C@H](NC(=O)OC(C)(C)C)[C@H]2CN(C3(c4cccc(C(C)(C)C)c4)CC3)C(=O)O2)ccc1NC(=O)C(F)(F)F",
        "output": "717"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)C(C)(C)c1ccc(Cl)nc1.[Na+].[OH-]>>CC(C)(C(=O)O)c1ccc(Cl)nc1",
        "output": "615"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)CNC(=O)NCCNC(=O)Nc1cccc(C)c1-c1cccc(S(=O)(=O)c2cc(C(=N)NC(=O)OC(C)(C)C)sc2SC)c1.O.[Na+].[OH-]>>CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2NC(=O)NCCNC(=O)NCC(=O)O)c1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCc1c(OCCCN=[N+]=[N-])ccc2c(C(F)(F)F)noc12.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCc1c(OCCCN)ccc2c(C(F)(F)F)noc12",
        "output": "89"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C[Si](C)(C)I.Cc1nn(C(=O)OC(C)(C)C)c2ccc(NS(=O)(=O)c3ccc(Cl)c(Cl)c3)cc12.ClC(Cl)Cl>>Cc1n[nH]c2ccc(NS(=O)(=O)c3ccc(Cl)c(Cl)c3)cc12",
        "output": "896"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "B.C1CCOC1.C1CCOC1.CNC(=O)Cc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc(Cl)c2Cl)c1.Cl.[Na+].[OH-]>>CNCCc1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc(Cl)c2Cl)c1",
        "output": "112"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc2c(cc1OC)CC(=O)N(CCCN(C)CCSc1ccccc1)CC2.OO>>COc1cc2c(cc1OC)CC(=O)N(CCCN(C)CCS(=O)c1ccccc1)CC2",
        "output": "199"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)c1ccc(Cl)c([N+](=O)[O-])c1.CN.CO>>CNc1ccc(C(C)=O)cc1[N+](=O)[O-]",
        "output": "304"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.Nc1cc(C(F)(F)F)ccc1Br.O=C(Cl)CCl>>O=C(CCl)Nc1cc(C(F)(F)F)ccc1Br",
        "output": "9"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCCNCC1.CCOC(C)=O.O.O=C([O-])[O-].O=[N+]([O-])c1cccc(Br)c1.[Cs+].[Cs+]>>CC(C)(C)OC(=O)N1CCCN(c2cccc([N+](=O)[O-])c2)CC1",
        "output": "294"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](Nc2cc(Cl)ncc2C(N)=O)[C@@H](CO)C1.CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.O.c1c[nH]cn1>>CC(C)(C)OC(=O)N1CC[C@@H](Nc2cc(Cl)ncc2C(N)=O)[C@@H](CO[Si](C)(C)C(C)(C)C)C1",
        "output": "193"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)c1ccc(Cn2ccc3cc(Br)ccc32)cc1.OB(O)c1ccc(Cl)cc1>>CC(C)(C)c1ccc(Cn2ccc3cc(-c4ccc(Cl)cc4)ccc32)cc1",
        "output": "837"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1nc2ccc(C(F)(F)F)cc2s1.O=C(Cl)Cc1ccccc1>>O=C(Cc1ccccc1)Nc1nc2ccc(C(F)(F)F)cc2s1",
        "output": "553"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CS(C)=O.Cl.N#Cc1ccc(-c2ccc(F)cc2)nc1Cl.N#Cc1ccc(NC2CCCNC2)nc1N>>N#Cc1ccc(NC2CCCN(c3nc(-c4ccc(F)cc4)ccc3C#N)C2)nc1N",
        "output": "220"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOCC.CO.COc1ccc(COc2cnc(CN3C(=O)c4ccccc4C3=O)cc2OCc2ccc(OC)cc2)cc1.ClC(Cl)Cl.NN.O.O=c1[nH][nH]c(=O)c2ccccc12>>COc1ccc(COc2cnc(CN)cc2OCc2ccc(OC)cc2)cc1",
        "output": "242"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CC(C)(O)c1ccccc1.CC(C)NC(=O)c1cn(-c2cccc(Br)c2)c2ncccc2c1=O.CCN(CC)CC.CN(C)C=O.[Cu]I.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC(C)NC(=O)c1cn(-c2cccc(C#CC(C)(O)c3ccccc3)c2)c2ncccc2c1=O",
        "output": "659"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.NCCN1CCCCC1.O=C(O)Cn1c(-c2ccc(Br)cc2)nc2cccnc21>>O=C(Cn1c(-c2ccc(Br)cc2)nc2cccnc21)NCCN1CCCCC1",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Clc1ccc(CBr)cc1.O.O=c1ccc(Br)c[nH]1>>O=c1ccc(Br)cn1Cc1ccc(Cl)cc1",
        "output": "528"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.N#Cc1ccc(O)c(C(F)(F)F)c1.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)nc1.[K+].[K+]>>N#Cc1ccc(Oc2ccc([N+](=O)[O-])cn2)c(C(F)(F)F)c1",
        "output": "516"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)c1ccc(Cl)c(Cl)c1.CCO.CN.Cl.[BH3-]C#N.[Na+]>>CNC(C)c1ccc(Cl)c(Cl)c1",
        "output": "693"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)CCCCCCN.Nc1ccccc1.O=C(O)c1cc2ccccc2[nH]1>>COC(=O)CCCCCCNC(=O)c1cc2ccccc2[nH]1",
        "output": "137"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.COC(=O)c1ccc(O)cc1.FCCBr.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(OCCF)cc1",
        "output": "385"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc2c(c1)CCn1c-2cc(Cl)nc1=O.Nc1ccccc1Br>>COc1ccc2c(c1)CCn1c-2cc(Nc2ccccc2Br)nc1=O",
        "output": "161"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.ClCCl.Nc1ccc(Cl)cc1.O=C(Cl)c1cc(Cl)ccc1[N+](=O)[O-]>>O=C(Nc1ccc(Cl)cc1)c1cc(Cl)ccc1[N+](=O)[O-]",
        "output": "11"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C=C(C#N)C(=O)N1CCC[C@@H]1Cn1c(NC(=O)c2ccc(C(F)F)s2)nc2ccccc21)CO[Si](C)(C)C(C)(C)C.CO.Cl>>CC(C)(C=C(C#N)C(=O)N1CCC[C@@H]1Cn1c(NC(=O)c2ccc(C(F)F)s2)nc2ccccc21)CO",
        "output": "708"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNC1.CCN(CC)CCNC(=O)c1c(C)[nH]c(C=O)c1C.CCO.O=C1Cc2cc(F)ccc2N1>>CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\\C(=O)Nc3ccc(F)cc32)c1C",
        "output": "911"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1ccc(OCCCCCCCCCCCCCCC(=O)OC(C)(C)C)c(C(=O)OC(C)(C)C)c1.Cl.O.[Na+].[OH-]>>CC(C)(C)OC(=O)CCCCCCCCCCCCCCOc1ccc(C(=O)O)cc1C(=O)OC(C)(C)C",
        "output": "222"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Nc1ccc(O)cc1.O=C(O)c1cc([N+](=O)[O-])c(Sc2c(Cl)cncc2Cl)s1>>O=C(Nc1ccc(O)cc1)c1cc([N+](=O)[O-])c(Sc2c(Cl)cncc2Cl)s1",
        "output": "822"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.CCOCC.Cc1cc(CCC(=O)c2sc(C)c3c2CCC(C)(C)C3)cc(C)c1O.ClCC1CO1.[Na+].[OH-]>>Cc1cc(CCC(=O)c2sc(C)c3c2CCC(C)(C)C3)cc(C)c1OCC1CO1",
        "output": "15"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CCNC(=O)OC.CC(c1cnc(Cl)c(Br)c1)N(C(=O)OC(C)(C)C)C1CC1.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>COC(=O)NCC#Cc1cc(C(C)N(C(=O)OC(C)(C)C)C2CC2)cnc1Cl",
        "output": "719"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCc1ccc(OCc2sc(C)cc2-c2ccc(CC)cc2)c(F)c1F.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCc1ccc(-c2cc(C)sc2COc2ccc(CCCO)c(F)c2F)cc1",
        "output": "225"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)C[C@@H](N)C(=O)NC1Cc2cccc(N3CCCC3=O)c2N(Cc2ccsc2)C1=O.C[C@@H](NC(=O)OC(C)(C)C)C(=O)O>>CC(C)C[C@@H](NC(=O)[C@@H](C)NC(=O)OC(C)(C)C)C(=O)NC1Cc2cccc(N3CCCC3=O)c2N(Cc2ccsc2)C1=O",
        "output": "133"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.COc1ccc(C2(C)C(=O)Nc3cc(Cl)cc(Cl)c3C2=O)cc1.Cl.ClCCl>>CC1(c2ccc(O)cc2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)C(C)N1C(=O)OC[C@@H]1c1ccccc1.O.O=C1CCN1.[Li+].[OH-]>>CC(C(=O)O)N1C(=O)OC[C@@H]1c1ccccc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)O.Clc1nccnc1OCC1CO1.NCCOc1ccc(C(N)=O)cc1>>NC(=O)c1ccc(OCCNCC(O)COc2nccnc2Cl)cc1",
        "output": "16"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)c1cccc(-c2nc(-c3cccnc3)no2)c1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)c1cccc(-c2nc(-c3cccnc3)no2)c1",
        "output": "752"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN.CO.Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N(C)c3ccccc3C=O)cc2)cc1.ClC(Cl)Cl.[BH4-].[Na+]>>CNCc1ccccc1N(C)C(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(C)cc2)cc1",
        "output": "468"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CO.COC(=O)CCc1ccc(OCCc2nc(-c3ccc(N4CCOCC4)cc3)oc2C)cc1CCNC(=O)OC(C)C.Cl.[Li+].[OH-]>>Cc1oc(-c2ccc(N3CCOCC3)cc2)nc1CCOc1ccc(CCC(=O)O)c(CCNC(=O)OC(C)C)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1ccc(NC2CCNCC2)cc1.ClC(Cl)Cl.ClCCCl.O=C([O-])O.O=CCC1(CCN2CCOCC2)CCCCC1.[Na+].[Na+]>>Cc1ccc(NC2CCN(CCC3(CCN4CCOCC4)CCCCC3)CC2)cc1",
        "output": "484"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1cccc(C2=CCN(C(=O)[C@H]3NCC4(CC4)C[C@@H]3C(=O)NO)CC2)c1.CO.O=S(=O)([O-])[O-].[Ba+2]>>CC(C)c1cccc(C2CCN(C(=O)[C@H]3NCC4(CC4)C[C@@H]3C(=O)NO)CC2)c1",
        "output": "806"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(Cl)Cl.CN1CCNCC1.COc1cc(N2CCC(=O)CC2)ccc1[N+](=O)[O-].O.[Na+].[Na+].[OH-]>>COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1[N+](=O)[O-]",
        "output": "187"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1cncc(C(=O)Nc2cnc(OCC(F)(F)F)c(-c3ccc(Cl)cc3)c2)c1.CO.O>>O=C(O)c1cncc(C(=O)Nc2cnc(OCC(F)(F)F)c(-c3ccc(Cl)cc3)c2)c1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CCC(CO)(CO)C(=O)O.CC(C)=O.CI.O=C([O-])[O-].[K+].[K+]>>C=CCC(CO)(CO)C(=O)OC",
        "output": "415"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(NCCCNC(=O)OC(C)(C)C)c1nc2snc(C)c2c(=O)n1Cc1ccccc1.CCN(CC)CC.ClCCl.O=C(Cl)c1ccc(Cl)cc1>>CCC(c1nc2snc(C)c2c(=O)n1Cc1ccccc1)N(CCCNC(=O)OC(C)(C)C)C(=O)c1ccc(Cl)cc1",
        "output": "201"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CC(C)O.CC(C)OC(C)C.Nc1ncc(Cl)cc1/C=C/C(=O)O>>Nc1ncc(Cl)cc1/C=C/C(=O)N1CCOCC1",
        "output": "811"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=[N+]([O-])c1ccc(Nc2c[nH]nc2-c2ccccn2)nc1.[Pd]>>Nc1ccc(Nc2c[nH]nc2-c2ccccn2)nc1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCO.CS(=O)(=O)c1nc(Oc2cccnc2)c(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)n1.[Li]CCCC>>CCCCOc1nc(Oc2cccnc2)c(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)n1",
        "output": "667"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.Nc1ccc(NC(=O)c2ccco2)cc1.O=C(Cl)C(=O)Cl.O=C(O)c1sc2ccccc2c1Cl>>O=C(Nc1ccc(NC(=O)c2sc3ccccc3c2Cl)cc1)c1ccco1",
        "output": "822"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cc(Br)c(CN2CCN(C(=O)OC(C)(C)C)CC2)cc1N.Nc1c(Br)cc(C(F)(F)F)cc1C(=O)O.[K+].[OH-]>>CC(C)(C)OC(=O)N1CCN(Cc2cc(N)c(C(=O)O)cc2Br)CC1",
        "output": "5"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CC(C)(C)C(=O)Cl.CCN(CC)CC.COc1ccccc1N.O>>COc1ccccc1NC(=O)C(C)(C)C",
        "output": "9"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1ccc(-c2nc(-c3nc(N)nc(N(C)c4ccccc4)n3)no2)cn1.[BH4-].[Na+]>>CN(c1ccccc1)c1nc(N)nc(-c2noc(-c3ccc(CO)nc3)n2)n1",
        "output": "546"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCCCCBr.CCO.O.O=C([O-])[O-].O=c1ccc2ccc(O)cc2[nH]1.[K+].[K+]>>O=c1ccc2ccc(OCCCCBr)cc2[nH]1",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CC(C)(C)c1ccc(Br)c[n+]1[O-].CCN(CC)CC.C[Si](C)(C)C#N>>CC(C)(C)c1ccc(Br)c(C#N)n1",
        "output": "720"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Brc1cccc2[nH]ccc12.C1CCOC1.CCOC(C)=O.COc1ccc(B(O)O)cc1.[Na+].[OH-].[Pd]>>COc1ccc(-c2cccc3[nH]ccc23)cc1",
        "output": "909"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1cccc(-c2c(C(=O)c3ccccc3)cnc3c(C(F)(F)F)cccc23)c1.O=Cc1ccc(-c2ccc(C(=O)O)cc2)cc1>>O=C(O)c1ccc(-c2ccc(CNc3cccc(-c4c(C(=O)c5ccccc5)cnc5c(C(F)(F)F)cccc45)c3)cc2)cc1",
        "output": "359"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NCC1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1.[Pd]>>Nc1ccc(CN2CCC(CNC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)CC2)cc1",
        "output": "507"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CO.Cc1csc([C@H]2CCCN2C(=O)c2cc(CF)cc(C(=O)N[C@@H](Cc3ccccc3)[C@H](O)[C@H]3C[C@@H](OCc4ccccc4)CN3C(=O)OC(C)(C)C)c2)n1.Cl.O=C([O-])O.[Na+]>>Cc1csc([C@H]2CCCN2C(=O)c2cc(CF)cc(C(=O)N[C@@H](Cc3ccccc3)[C@H](O)[C@H]3C[C@@H](OCc4ccccc4)CN3)c2)n1",
        "output": "575"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC(CCCN(CC)CC)Nc1c2ccccc2nc2ccccc12.CCCC(N)CCCN(CC)CC.CCN(CC)CC.Cl.Cl.Clc1c2ccccc2nc2ccccc12.Oc1ccccc1>>CCCC(CCCN(CC)CC)Nc1c2ccccc2nc2ccccc12",
        "output": "78"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cc1cc(C(F)(F)F)nn1-c1ccc(C(=O)Nc2ccc(Cl)cc2)cc1[N+](=O)[O-].Cl>>Cc1cc(C(F)(F)F)nn1-c1ccc(C(=O)Nc2ccc(Cl)cc2)cc1N",
        "output": "489"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.O=C(N1CCC(C2c3ccccc3Oc3cc(-c4ccncc4)ccc32)CC1)C(F)(F)F.O=C(N1CCC(C2c3ccccc3Oc3cc(-c4nnn[nH]4)ccc32)CC1)C(F)(F)F.[Na+].[OH-]>>c1ccc2c(c1)Oc1cc(-c3nnn[nH]3)ccc1C2C1CCNCC1",
        "output": "703"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC1([C@H]2CNC[C@H]2F)CC1.CN1CCCCC1.CS(C)=O.Cc1c(F)c(F)c(N)c2c(=O)c(C(=O)O)cn([C@@H]3C[C@@H]3F)c12>>Cc1c(N2C[C@@H](F)[C@@H](C3(NC(=O)OC(C)(C)C)CC3)C2)c(F)c(N)c2c(=O)c(C(=O)O)cn([C@@H]3C[C@@H]3F)c12",
        "output": "676"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCc1cc([N+](=O)[O-])ccc1C#N.Cl.[Fe]>>CCc1cc(N)ccc1C#N",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.Cl.ClCCl.N[C@@H]1CC[C@@H](Oc2cc(F)ccc2[N+](=O)[O-])CC1.O=C([O-])[O-].O=S(=O)([O-])O.[K+].[K+].[K+]>>CC(=O)N[C@@H]1CC[C@@H](Oc2cc(F)ccc2[N+](=O)[O-])CC1",
        "output": "339"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1cc(-c2ccccc2)nn(CC(C)C)c1=O.Cc1ccc(-c2cc(C(=O)O)c(=O)n(CC(C)C)n2)cc1F>>CC(C)Cn1nc(-c2ccccc2)cc(C(=O)O)c1=O",
        "output": "152"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.COc1c(OCCCNC(=O)OC(C)(C)C)ccc2c1N=C(NC(=O)c1cccnc1)N1CCN=C21.ClCCl.O=C(O)C(F)(F)F>>COc1c(OCCCN)ccc2c1N=C(NC(=O)c1cccnc1)N1CCN=C21",
        "output": "538"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1ccc2c(c1)N(CCN1CCC(N)CC1)C(=O)CO2.O=Cc1ccc2c(n1)NC(=O)CO2.[BH3-]C#N.[Na+]>>CC(=O)c1ccc2c(c1)N(CCN1CCC(NCc3ccc4c(n3)NC(=O)CO4)CC1)C(=O)CO2",
        "output": "775"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc(C(=O)Cl)cc(OC)c1OC.O=C1NCN(c2ccccc2)C12CCNCC2>>COc1cc(C(=O)N2CCC3(CC2)C(=O)NCN3c2ccccc2)cc(OC)c1OC",
        "output": "201"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)CC(=O)c1cccc(-n2cnnc2)c1.CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2F)cc1N>>CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2F)cc1NC(=O)CC(=O)c1cccc(-n2cnnc2)c1",
        "output": "929"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "N#Cc1cc(N)ccc1N1CCN(C2CCOCC2)CC1.O=C(O)c1ccn(-c2ccc(Cl)cc2)c1>>N#Cc1cc(NC(=O)c2ccn(-c3ccc(Cl)cc3)c2)ccc1N1CCN(C2CCOCC2)CC1",
        "output": "739"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)Cn1cccc(N)c1=O.CCOC(C)=O.Cc1cc(C)nc(C)c1.O=S(=O)(Cl)Cc1ccccc1>>CCOC(=O)Cn1cccc(NS(=O)(=O)Cc2ccccc2)c1=O",
        "output": "812"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOCC.CN(C)C=O.OCc1cccnc1Cl.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCc1cccnc1Cl",
        "output": "193"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CCOC(=O)[C@@H]1CN(C(=O)OCc2ccccc2)C[C@H]1C(F)(F)F.[Na+].[OH-]>>O=C(O)[C@@H]1CN(C(=O)OCc2ccccc2)C[C@H]1C(F)(F)F",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)OC(C)(C)C.Cl.O.[BH4-].[Li+]>>CC(C)(C)OC(=O)N1C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@@H]1CO",
        "output": "430"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Nc1cc(F)c(C(=O)O)cc1[N+](=O)[O-].O=S(=O)(O)O>>COC(=O)c1cc([N+](=O)[O-])c(N)cc1F",
        "output": "33"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCNC.COc1ccc2nc(-c3ccc(F)nc3)sc2c1.O>>CCN(C)c1ccc(-c2nc3ccc(OC)cc3s2)cn1",
        "output": "756"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(B3OC(C)(C)C(C)(C)O3)c(C)c2)cc1C)CC.COC(=O)Cc1ccc(OC)c(Br)c1.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1ccccc1.O.O=C([O-])O.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Na+].[Pd+2]>>CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(-c3cc(CC(=O)OC)ccc3OC)c(C)c2)cc1C)CC",
        "output": "933"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CI.CN(C)C=O.O.O=C([O-])[O-].O=Cc1cccc(O)c1O.[K+].[K+]>>COc1c(O)cccc1C=O",
        "output": "62"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2cc3c(cnn3C3CCCCO3)cc2OCc2ccccc2)cn1.CCO.CCOC(C)=O.[Pd]>>CC(C)(C)OC(=O)Nc1ccc(-c2cc3c(cnn3C3CCCCO3)cc2O)cn1",
        "output": "23"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1csc2c1CCNCC2c1ccccc1.CCN(CC)CC.Cl.ClCCl.O.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(N1CCc2c(Br)csc2C(c2ccccc2)C1)C(F)(F)F",
        "output": "397"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)Cl.CCCCCCCCCCCCCCCCNCC(O)CO.ClC(Cl)Cl>>CCCCCCCCCCCCCCCCN(CC(O)CO)C(C)=O",
        "output": "125"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cnc(NCC(F)(F)c2ccccn2)c(=O)n1CC(=O)O.NCCc1ccccc1>>Cc1cnc(NCC(F)(F)c2ccccn2)c(=O)n1CC(=O)NCCc1ccccc1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(=O)c1ccnn1-c1ccccc1.[Na+].[OH-]>>O=C(O)c1ccnn1-c1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)c1cc(C2CCN(C(=O)OCc3ccccc3)CC2)c(F)cc1SC.O.[Li+].[OH-]>>CSc1cc(F)c(C2CCN(C(=O)OCc3ccccc3)CC2)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)C(C)(C)CN1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)C(C)(C)CN1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CC(=O)[O-].CC(=O)c1cc(Cl)c(C)c(C#N)c1-c1cccc(F)c1.CO.[BH3-]C#N.[NH4+].[Na+]>>Cc1c(Cl)cc(C(C)N)c(-c2cccc(F)c2)c1C#N",
        "output": "552"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.CI.O=C([O-])[O-].Oc1c(Br)cccc1Br.[K+].[K+]>>COc1c(Br)cccc1Br",
        "output": "62"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CNC.Cc1ccc2oc(-c3cc([N+](=O)[O-])ccc3Cl)nc2c1.Cl[Cu].[Cu]>>Cc1ccc2oc(-c3cc([N+](=O)[O-])ccc3N(C)C)nc2c1",
        "output": "105"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.Cc1cc(Nc2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3)cn2)nc(N)n1.[Pd]>>Cc1cc(Nc2ccc(NC(=O)c3ccc(N)cc3)cn2)nc(N)n1",
        "output": "28"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.Cc1c(C(=O)NN2CCCCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(C#CCO)cc1.ClCCl.[Pd]>>Cc1c(C(=O)NN2CCCCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(CCCO)cc1",
        "output": "717"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.CN(CCCCl)C(=O)OCc1ccccc1.Cc1ccc(-n2c(C)nc(Cl)c2-c2c(F)cc(O)cc2F)cc1.O=C([O-])[O-].[Cs+].[Cs+].[I-]>>Cc1ccc(-n2c(C)nc(Cl)c2-c2c(F)cc(OCCCN(C)C(=O)OCc3ccccc3)cc2F)cc1",
        "output": "74"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.Cc1ccccc1.O=C=Nc1cccc(Cl)c1Cl>>COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(Cl)c4Cl)cc3)c2cc1OC",
        "output": "912"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1cccc(NC(=O)NC2CN(C3CCCCC3)c3ccc(C)cc3N(CC(=O)C(C)(C)C)C2=O)c1.CO.O.[Li+].[OH-]>>Cc1ccc2c(c1)N(CC(=O)C(C)(C)C)C(=O)C(NC(=O)Nc1cccc(C(=O)O)c1)CN2C1CCCCC1",
        "output": "5"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClC(Cl)Cl.N#CCOc1ccc(CO)cc1.O=S(Cl)Cl>>N#CCOc1ccc(CCl)cc1",
        "output": "81"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CN(C)C=O.Cc1cc(C#N)ccc1Br.[K+].[Pd+2]>>Cc1cc(C#N)ccc1B1OC(C)(C)C(C)(C)O1",
        "output": "942"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CCCO.ClCCl.O=S(Cl)Cl>>CCN(CC)CCCCl",
        "output": "96"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.OC1CNC1>>CC(C)(C)OC(=O)N1CC(O)C1",
        "output": "694"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNCC1.CCN(CC)CCCc1ccc2[nH]c(C=O)cc2c1.CCO.O=C1Cc2ccccc2N1>>CCN(CC)CCCc1ccc2[nH]c(C=C3C(=O)Nc4ccccc43)cc2c1",
        "output": "440"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.Cl.NO.O=C(O)CCCCCCC(=O)c1ccc(Br)cc1>>O=C(CCCCCCC(=O)c1ccc(Br)cc1)NO",
        "output": "480"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#CCOc1ccc(C(=O)O)cc1OC.CN(C)C=O.Cc1ccccc1.O=S(Cl)Cl>>C#CCOc1ccc(C(=O)Cl)cc1OC",
        "output": "3"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COCC(C)(C)C1Cc2cc(OCCCCCCNC(=O)OC(C)(C)C)c(OC)cc2-c2cc(=O)c(C(=O)O)cn21.Cl.O=C([O-])[O-].[Na+].[Na+]>>COCC(C)(C)C1Cc2cc(OCCCCCCN)c(OC)cc2-c2cc(=O)c(C(=O)O)cn21",
        "output": "538"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.COc1cc(OCC2CC2)c(Br)cn1.O.[Cl-].[Li+]>>Oc1cc(OCC2CC2)c(Br)cn1",
        "output": "408"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.COC(C)(C)C.COc1ccc(CCNC(=O)[C@@H]2CCCN2C(=O)OC(C)(C)C)cc1.Cl>>COc1ccc(CCNC(=O)[C@@H]2CCCN2)cc1",
        "output": "634"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCC(=O)Cl.Cl.ClCCl.NCCS.O.O=C([O-])[O-].[K+].[K+]>>CCCCC(=O)NCCS",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCn1cc(C(=O)OC)c2ccc(OC)cc2c1=O.CO.O.[Li+].[OH-]>>CCn1cc(C(=O)O)c2ccc(OC)cc2c1=O",
        "output": "152"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCN1.CCOC(=O)c1cnc(Cl)cc1N>>CCOC(=O)c1cnc(N2CCOCC2)cc1N",
        "output": "220"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Clc1nccc2ccccc12.O.c1ccc(CN2CCNCC2)cc1>>c1ccc(CN2CCN(c3nccc4ccccc34)CC2)cc1",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1.O=[N+]([O-])c1ccccc1S(=O)(=O)Cl.c1ccncc1>>O=C1CC(=O)N(c2ccc(NS(=O)(=O)c3ccccc3[N+](=O)[O-])cc2)c2ccc3ccccc3c2N1",
        "output": "68"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CO.COC(=O)c1scc2c1nc(Cl)c1nn(Cc3ccc(OC)cc3)cc12.Cl.Nc1ccc(N2CCN(C3CC3)CC2)cc1>>COC(=O)c1scc2c1nc(Nc1ccc(N3CCN(C4CC4)CC3)cc1)c1n[nH]cc12",
        "output": "998"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "N#Cc1cc(Br)c2c(c1)cc1n2CCNC1=O.N#Cc1cccc(B(O)O)c1>>N#Cc1cccc(-c2cc(C#N)cc3cc4n(c23)CCNC4=O)c1",
        "output": "833"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)CCN.COc1cc(C(=O)O)ccc1Nc1cncc(-c2ccc(O)cc2)n1.F[B-](F)(F)F>>COc1cc(C(=O)NCCN(C)C)ccc1Nc1cncc(-c2ccc(O)cc2)n1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)c1cc(O)ccc1O.CC(C)=O.CCCCCCCCCCCCC(Br)C(=O)OCC.O=C([O-])[O-].[K+].[K+]>>CCCCCCCCCCCCC(Oc1ccc(O)c(C(C)(C)C)c1)C(=O)OCC",
        "output": "455"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)CC(C(=O)OCc1ccccc1)c1ccc(Br)cc1.[Cl-].[NH4+]>>NC(=O)CC(C(=O)OCc1ccccc1)c1ccc(Br)cc1",
        "output": "313"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1ccccn1.CC(C)(C)[O-].CC(C)(C)[Si](C)(C)Oc1ccc(C2(CN)CCOCC2)cc1.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CC(C)(C)[Si](C)(C)Oc1ccc(C2(CNc3ccccn3)CCOCC2)cc1",
        "output": "715"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(=O)Nc1cccc(C2CCNCC2)c1.O=C(CCCCCl)c1cccc(F)c1>>CCC(=O)Nc1cccc(C2CCN(CCCCC(=O)c3cccc(F)c3)CC2)c1",
        "output": "138"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCCP(CCCC)CCCC.CCOC(=O)CCc1ccc(O)cc1C.OCc1cccc(-c2ccc(C(F)(F)F)cc2)c1>>CCOC(=O)CCc1ccc(OCc2cccc(-c3ccc(C(F)(F)F)cc3)c2)cc1C",
        "output": "347"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.O=[N+]([O-])c1ccc2[nH]nc(-c3ncco3)c2c1.[Pd]>>Nc1ccc2[nH]nc(-c3ncco3)c2c1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=C(CCO)[C@H]1CC[C@H]2[C@@H](O[Si](C)(C)C(C)(C)C)CCC[C@]12C.CC(C)(C)[Si](C)(C)Cl.ClCCl.O.c1c[nH]cn1>>C=C(CCO[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H](O[Si](C)(C)C(C)(C)C)CCC[C@]12C",
        "output": "193"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.Nc1ccccc1.O.O=C(O)c1ccccn1.O=C(n1ccnc1)n1ccnc1.[Na+].[OH-]>>O=C(Nc1ccccc1)c1ccccn1",
        "output": "548"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN.O=S1(=O)N(CCOCCBr)c2ccccc2N1c1ccccc1F>>CNCCOCCN1c2ccccc2N(c2ccccc2F)S1(=O)=O",
        "output": "147"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCOP(=O)(C#N)OCC.COC(=O)c1cc2c(o1)CNCC2.ClCCl.O=C(O)c1ccc(C(=O)c2ccccc2)cc1>>COC(=O)c1cc2c(o1)CN(C(=O)c1ccc(C(=O)c3ccccc3)cc1)CC2",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)S(=O)(=O)c1ccccc1Nc1nc(Cl)ncc1Cl.CCN(C(C)C)C(C)C.NCc1cccc([N+](=O)[O-])c1>>CC(C)S(=O)(=O)c1ccccc1Nc1nc(NCc2cccc([N+](=O)[O-])c2)ncc1Cl",
        "output": "364"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CN1CCC(C(=O)c2cccc(N)n2)CC1.CO.O=C(Cl)c1ccccc1Cl>>CN1CCC(C(=O)c2cccc(NC(=O)c3ccccc3Cl)n2)CC1",
        "output": "463"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)CBr.COc1cc(CC2c3cc(OC)c(OC)cc3CCN2CC(=O)NCc2ccccc2)ccc1O>>CCOC(=O)COc1ccc(CC2c3cc(OC)c(OC)cc3CCN2CC(=O)NCc2ccccc2)cc1OC",
        "output": "123"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)c1ccccc1.N#Cc1c(O)nc(-c2ccc([N+](=O)[O-])cc2)nc1C(F)(F)F.O=P(Cl)(Cl)Cl>>N#Cc1c(Cl)nc(-c2ccc([N+](=O)[O-])cc2)nc1C(F)(F)F",
        "output": "25"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.O.O=C1CCC(=O)N1I.O=S(=O)(O)O.Oc1ccc(Br)cc1>>Oc1ccc(Br)cc1I",
        "output": "834"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCCCC.CCOC(C)=O.C[O-].O=[N+]([O-])c1c(F)cc(F)c(F)c1Nc1ccc(I)cc1F.[Na+]>>COc1cc(F)c(F)c(Nc2ccc(I)cc2F)c1[N+](=O)[O-]",
        "output": "485"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C=O.CC1(C)O[C@@H]2[C@H](O1)[C@@H](CNCCCCc1nc3cc(C(F)(F)F)c(Cl)cc3n1COCC[Si](C)(C)C)C[C@H]2n1ccc2c(NC3CC3)ncnc21.CO.[BH3-]C#N.[Na+]>>CN(CCCCc1nc2cc(C(F)(F)F)c(Cl)cc2n1COCC[Si](C)(C)C)C[C@H]1C[C@@H](n2ccc3c(NC4CC4)ncnc32)[C@@H]2OC(C)(C)O[C@H]12",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(CN)CC1.CCN(C(C)C)C(C)C.CN1CCCC1=O.Nc1ncnc(Cl)c1Cl>>CC(C)(C)OC(=O)N1CCC(CNc2ncnc(N)c2Cl)CC1",
        "output": "110"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)Cl.C[C@H]1CC[C@@H](Nc2ncc(-c3ccc(N4CCOCC4)cc3)c(OC[C@@H]3CCNC3)n2)CC1>>C[C@H]1CC[C@@H](Nc2ncc(-c3ccc(N4CCOCC4)cc3)c(OC[C@@H]3CCN(S(C)(=O)=O)C3)n2)CC1",
        "output": "584"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.Nc1cc(C(F)(C(F)(F)F)C(F)(F)F)ccc1O.O=C(O)c1ccncc1Cl.c1ccncc1>>O=C(Nc1cc(C(F)(C(F)(F)F)C(F)(F)F)ccc1O)c1ccncc1Cl",
        "output": "50"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)S(=O)(=O)Cl.Cn1c(C#N)ccc1-c1ccc(N)cc1.O>>CC(C)S(=O)(=O)Nc1ccc(-c2ccc(C#N)n2C)cc1",
        "output": "194"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.Nc1cccc(Cl)c1Cl.O.O=N[O-].O=S(=O)([O-])[O-].[Br-].[Cu+2].[Na+].[Na+]>>Clc1cccc(Br)c1Cl",
        "output": "373"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCOc1cccc2ccncc12.ClCCl.O=C(OO)c1cccc(Cl)c1>>CCCOc1cccc2cc[n+]([O-])cc12",
        "output": "262"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCNCC(C)C.CS(C)=O.Cl.O.O=C([O-])[O-].O=Cc1cc(Br)ccc1F.[Na+].[Na+]>>CCN(CC(C)C)c1ccc(Br)cc1C=O",
        "output": "868"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1ncc2nc(Nc3ccccc3)sc2c1O.CO.C[O-].NCC(=O)O.[Na+]>>O=C(O)CNC(=O)c1ncc2nc(Nc3ccccc3)sc2c1O",
        "output": "977"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.[Na+].[OH-].c1cc2c3c(c1)C1CNCCC1N3CCN2>>CC(C)(C)OC(=O)N1CCC2C(C1)c1cccc3c1N2CCN3",
        "output": "694"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1cn2c3c(c(O)c(F)cc3c1=O)CCN2C.CS(=O)(=O)Cl.ClC(Cl)Cl.c1ccncc1>>COC(=O)c1cn2c3c(c(OS(C)(=O)=O)c(F)cc3c1=O)CCN2C",
        "output": "149"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CNCCN1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CCN1C(=O)C(C(=O)OC(C)(C)C)CCc2cc(Br)c(OC)cc21.[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CCN1C(=O)C(C(=O)OC(C)(C)C)CCc2cc(N3CCNCC3)c(OC)cc21",
        "output": "294"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#Cc1ccc2c(c1)OCC(C)(C)CO2.COc1ccc(I)cc1>>COc1ccc(C#Cc2ccc3c(c2)OCC(C)(C)CO3)cc1",
        "output": "664"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(CC)CC.NCCO.O=S(=O)(Cl)c1ccc(Br)cc1>>O=S(=O)(NCCO)c1ccc(Br)cc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCOC(=O)CBr.Cc1cccc(C)c1NC(=O)CN1CCNCC1.Cl.Cl.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1",
        "output": "467"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCCN.O=C(Cl)C(c1ccccc1)c1ccccc1>>CCCCCCCNC(=O)C(c1ccccc1)c1ccccc1",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)c1ccc(Nc2ccccc2[N+](=O)[O-])cc1.[Pd]>>CCOC(=O)c1ccc(Nc2ccccc2N)cc1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)CBr.CCOC(=O)CC(c1cccc(COc2ccc(-c3cc(OC)ccc3F)c(O)c2)c1)C1CC1.CN(C)C=O.O=C([O-])[O-].[Cl-].[H-].[K+].[K+].[NH4+].[Na+]>>COc1ccc(F)c(-c2ccc(OCc3cccc(C(CC(=O)O)C4CC4)c3)cc2O)c1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C.C1CCOC1.COC(=O)c1ccc(-c2nc3ccc(C(=O)O)cc3[nH]2)cc1.O.[Li+].[OH-]>>O=C(O)c1ccc(-c2nc3ccc(C(=O)O)cc3[nH]2)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCO.CCN(CC)CC.CO.Cc1cccc(-c2cc(Cl)nc(N)n2)c1C.NCc1cn2ccccc2n1>>Cc1cccc(-c2cc(NCc3cn4ccccc4n3)nc(N)n2)c1C",
        "output": "166"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)N1CCC(Oc2ccc3[nH]c(C(=O)N4CCNCC4)cc3c2)CC1.COC(=O)Cl.Cl.Cl>>COC(=O)N1CCN(C(=O)c2cc3cc(OC4CCN(C(C)C)CC4)ccc3[nH]2)CC1",
        "output": "219"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O.CCOC(C)=O.O.O=[N+]([O-])c1ccccc1Nc1ccc2c(c1)OCO2.[Fe]>>Nc1ccccc1Nc1ccc2c(c1)OCO2",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C(=O)OC(C)(C)C)C1CCC(N)CC1.COc1ccc(-c2ccncc2F)cc1C=O>>COc1ccc(-c2ccncc2F)cc1CNC1CCC(N(C)C(=O)OC(C)(C)C)CC1",
        "output": "468"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)OCCn2c1nc(C(=O)O)c(OCc1ccccc1)c2=O.NCc1ccccc1N1CCC1=O>>CC1(C)OCCn2c1nc(C(=O)NCc1ccccc1N1CCC1=O)c(OCc1ccccc1)c2=O",
        "output": "905"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CSc1ncc2cc(-c3ccc(-c4cncc(C)n4)cc3Cl)c(=O)n(CCOC3CN(C(=O)OC(C)(C)C)C3)c2n1.ClCCl.O=C(OO)c1cccc(Cl)c1>>Cc1cncc(-c2ccc(-c3cc4cnc(S(C)=O)nc4n(CCOC4CN(C(=O)OC(C)(C)C)C4)c3=O)c(Cl)c2)n1",
        "output": "595"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "ClCCl.Nc1nc(C(=O)N2Cc3ccccc3C2)c2cc(-c3cc(F)c(F)cc3CO)ccc2n1.O=S(Cl)Cl>>Nc1nc(C(=O)N2Cc3ccccc3C2)c2cc(-c3cc(F)c(F)cc3CCl)ccc2n1",
        "output": "81"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2N)c1.NS(=O)(=O)CCCC(=O)O.On1nnc2ccccc21>>CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2NC(=O)CCCS(N)(=O)=O)c1",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCc1nc2c(N)nc3ccccc3c2n1CCCNCc1cccc(CC(=O)OC)c1.Cl.ClC(Cl)Cl.O=C(Cl)CCl>>CCCCc1nc2c(N)nc3ccccc3c2n1CCCN(Cc1cccc(CC(=O)OC)c1)C(=O)CCl",
        "output": "240"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.COC(=O)c1ccc(NCC2CCC(F)(F)CC2)c([N+](=O)[O-])c1.[Pd]>>COC(=O)c1ccc(NCC2CCC(F)(F)CC2)c(N)c1",
        "output": "481"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COc1cccc(N)c1.N#Cc1ccc(C=O)cc1F>>COc1cccc(N=Cc2ccc(C#N)c(F)c2)c1",
        "output": "329"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1cnc2ccc(OC)cc2c1Br.CO.Cl.ClCCl.[Na+].[OH-]>>COc1ccc2ncc(C(=O)O)c(Br)c2c1",
        "output": "171"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CCNC2)CC1.CCN(C(C)C)C(C)C.CN(C)C=O.N#Cc1ccc(Cl)nc1.O>>CC(C)(C)OC(=O)N1CCC2(CC1)CCN(c1ccc(C#N)cn1)C2",
        "output": "220"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1=C(c2c[nH]c3ccccc23)CCN(CCOC2CCCCO2)C1.CCO.Cl.O.[Na+].[OH-]>>OCCN1CC=C(c2c[nH]c3ccccc23)CC1",
        "output": "543"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cccc(CCN)c1.O=Cc1ccccc1>>COc1cccc(CCN=Cc2ccccc2)c1",
        "output": "52"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.C[O-].Cc1cnc(F)c(C)c1I.[Na+]>>COc1ncc(C)c(I)c1C",
        "output": "541"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CC(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)O.CCN(CC)CC.NC1Cc2cccc(N3CCCC3=O)c2N(Cc2ccsc2)C1=O.O.O.O=C(O)[C@@H](O)[C@H](O)C(=O)O.[Cl-].[Na+].[Na+].[OH-]>>CC(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)NC1Cc2cccc(N3CCCC3=O)c2N(Cc2ccsc2)C1=O",
        "output": "133"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(=O)Cl.COc1cc(N)c(Cl)cc1C(=O)O.NCC1CCN(CCCn2ccnn2)CC1.O>>COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccnn2)CC1",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.C[C@@H](CC#N)Nc1ccccc1.O=C1CCC(=O)N1Br>>C[C@@H](CC#N)Nc1ccc(Br)cc1",
        "output": "4"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCO.O=C(NCCCCc1ccc(O)c2ccccc12)OCc1ccccc1.OCC1CO1>>O=C(NCCCCc1ccc(OCC(O)CO)c2ccccc12)OCc1ccccc1",
        "output": "277"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COc1ccc2nccc(NC(=O)[C@@H]3C[C@@H](O)[C@@H](CN)C3)c2n1.ClCCl.O=Cc1ccc2c(n1)NC(=O)CS2.[BH4-].[Na+]>>COc1ccc2nccc(NC(=O)[C@@H]3C[C@@H](O)[C@@H](CNCc4ccc5c(n4)NC(=O)CS5)C3)c2n1",
        "output": "775"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCc1ccc(S(=O)(=O)Cl)cc1.CCN(CC)CC.CCOC(=O)CC1(N)CCN(C)CC1.ClCCl>>CCCCCc1ccc(S(=O)(=O)NC2(CC(=O)OCC)CCN(C)CC2)cc1",
        "output": "43"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.C[C@@H](N)C(=O)NCCO.Cn1nc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)c2ccc(F)cc21.F[P-](F)(F)(F)(F)F.O=C(O)C(F)(F)F>>C[C@@H](NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)C(=O)NCCO",
        "output": "989"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)C1CCCC1)C(=O)CBr.CN(C)C=O.O.Oc1c(F)c(F)cc(F)c1F.[F-].[K+]>>CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)C1CCCC1)C(=O)COc1c(F)c(F)cc(F)c1F",
        "output": "221"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CCO.O=C(Cl)c1cccc(OC(F)(F)F)c1>>CCOC(=O)c1cccc(OC(F)(F)F)c1",
        "output": "51"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.CN(C)c1ccncc1.Nc1ccc(-c2cnc(NCCN3CCOCC3)nc2)cc1.O=C=Nc1cccc(C(F)(F)F)c1>>O=C(Nc1ccc(-c2cnc(NCCN3CCOCC3)nc2)cc1)Nc1cccc(C(F)(F)F)c1",
        "output": "473"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O.CN(C)C=O.Cl.Cn1cc(C[C@@H](N)C(=O)OCc2ccccc2)c2ccccc21.On1nnc2ccccc21>>CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)OCc1ccccc1",
        "output": "132"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)C=O.OCc1ccc(C2CCCCN2)cc1>>CC(C)(C)OC(=O)N1CCCCC1c1ccc(CO)cc1",
        "output": "867"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)Cl.Nc1cc(Br)cnc1Cl>>COC(=O)Nc1cc(Br)cnc1Cl",
        "output": "763"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)[PH+](C(C)(C)C)C(C)(C)C.Cc1cc(OCCCS(C)(=O)=O)cc(C)c1Br.F[B-](F)(F)F.O.O=Cc1cccc(B(O)O)c1.[Cl-].[Li+].[Pd+2]>>Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(C=O)c1",
        "output": "837"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.Cl.ClCCl.O.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1cc(N2C3CCC2CC3)ccc1F>>O=S(=O)(Oc1cc(N2C3CCC2CC3)ccc1F)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1nn(C(C)C)c2cc(N3CCN[C@@H](Cc4ccccc4)C3)ccc12.O=C(O)Cc1cnco1>>CCc1nn(C(C)C)c2cc(N3CCN(C(=O)Cc4cnco4)[C@@H](Cc4ccccc4)C3)ccc12",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1cccc2cnccc12.CN1CCNC(=O)C1.CS(C)=O.O=C([O-])[O-].[Cu]I.[K+].[K+].c1cnc2c(c1)ccc1cccnc12>>CN1CCN(c2cccc3cnccc23)C(=O)C1",
        "output": "809"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CNCCc1ccccc1.O=C(O)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1>>CN(CCc1ccccc1)C(=O)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1",
        "output": "44"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1cnn(-c2ccc(Br)cc2)n1.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1cnn(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)n1",
        "output": "942"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CN(C)C=O.CN(C)c1cc(Br)ccc1C=O.O.O=C([O-])[O-].OB(O)c1ccccc1.[Na+].[Na+].[Pd+2]>>CN(C)c1cc(-c2ccccc2)ccc1C=O",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=C1CC(NC(=O)OC(C)(C)C)C(C(=O)Nc2ccc(Cl)cc2)C1.ClCCl.O=C(O)C(F)(F)F>>C=C1CC(N)C(C(=O)Nc2ccc(Cl)cc2)C1",
        "output": "538"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)Cl.NCc1nn(NC(=O)Cc2ccc(Cl)cc2)c(=O)c2ccccc12>>CCOC(=O)NCc1nn(NC(=O)Cc2ccc(Cl)cc2)c(=O)c2ccccc12",
        "output": "94"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)Cn1cc(-c2c(C#N)c(N)nc(SCc3csc(-c4ccc(Cl)cc4)n3)c2C#N)cn1.O.[BH4-].[Na+]>>N#Cc1c(N)nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c1-c1cnn(CCO)c1",
        "output": "343"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)CCc1ccccc1SC1=NCCS1.O.O.[Li+].[OH-]>>O=C(O)CCc1ccccc1SC1=NCCS1",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCC=Cc1c(C(C)C)nc(C(C)C)c(C(=O)OCC)c1-c1ccc(C)cc1.CCCCCC.CCOC(C)=O>>CCCC=Cc1c(C(C)C)nc(C(C)C)c(CO)c1-c1ccc(C)cc1",
        "output": "383"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.ClCCl.NCCc1c[nH]c2cc(F)ccc12>>CC(=O)NCCc1c[nH]c2cc(F)ccc12",
        "output": "339"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)C(C)(C)c1cc(-c2ccncc2)cc([N+](=O)[O-])c1.CO.[Pd]>>CC(C)(C)OC(=O)C(C)(C)c1cc(N)cc(-c2ccncc2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cn1nc(NCC(=O)NC2CNC2)c2cc(C(F)C(F)(F)F)ccc21.O=C(O)C(F)(F)F.O=C1CCC(O)(c2cncs2)CC1>>Cn1nc(NCC(=O)NC2CN(C3CCC(O)(c4cncs4)CC3)C2)c2cc(C(F)C(F)(F)F)ccc21",
        "output": "187"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O.O=C1CC(c2cccc(Br)c2)=Nc2ccc([N+](=O)[O-])cc2N1.[Cl-].[Fe].[NH4+]>>Nc1ccc2c(c1)NC(=O)CC(c1cccc(Br)c1)=N2",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)C=O.COP(=O)(CN)OC.C[C@H](NC(=O)OCc1ccccc1)C(=O)O.Cl>>COP(=O)(CNC(=O)[C@H](C)NC(=O)OCc1ccccc1)OC",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)[C@H](Cc1ccc(OCCc2ccc(N)cc2)cc1)OCC.Cl.O=C(Cl)OCc1ccccc1>>CCOC(=O)[C@H](Cc1ccc(OCCc2ccc(NC(=O)OCc3ccccc3)cc2)cc1)OCC",
        "output": "509"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOCC.Clc1ccc(C(OC2CCN(Cc3ccccc3)CC2)c2ccc(Cl)cc2)cc1.Clc1ccc(C(OC2CCNCC2)c2ccccc2Cl)cc1>>Clc1ccc(C(OC2CCNCC2)c2ccc(Cl)cc2)cc1",
        "output": "84"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.COc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc2cc(C3=NCC(CC(=O)O)S3)[nH]c12.C[C@@H](O)CN.Cl.O.On1nnc2ccccc21>>COc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc2cc(C3=NCC(CC(=O)NC[C@@H](C)O)S3)[nH]c12",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C#N)c1ccc(N)cc1Br.COCCOC.COc1ccc(B(O)O)cc1.O=C([O-])[O-].[K+].[K+]>>COc1ccc(-c2cc(N)ccc2C(C)(C)C#N)cc1",
        "output": "837"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COC(=O)C[C@@H]1c2ccccc2C[C@H]1N.Cl.O=C(O)c1cc2sc(Cl)c(Cl)c2[nH]1.On1nnc2ccccc21>>COC(=O)C[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1",
        "output": "137"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)Cl.CCN(CC)CC.COC(=O)c1ccc2c(c1)OC[C@@H](C)NC2.ClCCl>>COC(=O)c1ccc2c(c1)OC[C@@H](C)N(C(C)=O)C2",
        "output": "240"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCO.O=S(=O)(NCCCNCc1cccc2nccn12)C(F)(F)F>>CC(C)(C)OC(=O)N(CCCNS(=O)(=O)C(F)(F)F)Cc1cccc2nccn12",
        "output": "694"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1cc2n(n1)CCCN(C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2.OCCN1CCNCC1>>O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCn2nc(C(=O)N3CCN(CCO)CC3)cc2C1",
        "output": "663"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.COC(=O)C(C)(C)c1ccc(OS(=O)(=O)C(F)(F)F)cc1.Cl>>CC(C)(C(=O)O)c1ccc(OS(=O)(=O)C(F)(F)F)cc1",
        "output": "203"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cc2cc(Nc3ccnc4cc(-c5cccn5C(=O)OC(C)(C)C)sc34)ccc2[nH]1.ClCCl.O.O=C(O)C(F)(F)F.O=C([O-])[O-].[Na+].[Na+]>>Cc1cc2cc(Nc3ccnc4cc(-c5ccc[nH]5)sc34)ccc2[nH]1",
        "output": "848"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[O-].CN1CCCN(C)C1=O.Cc1cc(Cl)ccn1.Nc1ccc(O)cc1.O.[K+]>>Cc1cc(Oc2ccc(N)cc2)ccn1",
        "output": "351"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Oc1ccc2cc(C#CCCNC(=O)OCc3ccccc3)ccc2c1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>O=C(NCCC#Cc1ccc2cc(O)ccc2c1)OCc1ccccc1",
        "output": "754"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCNc1ncc2c(n1)N1CCC[C@H]1CN(c1cncc(N3CCNCC3)c1)C2=O.ClCCCl.O=C([O-])O.[Na+].[Na+]>>CCNc1ncc2c(n1)N1CCC[C@H]1CN(c1cncc(N3CCN(C)CC3)c1)C2=O",
        "output": "217"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1CCN(C2CCNCC2)CC1.CC(C)(C)[O-].CCOC(C)=O.Cc1ccccc1.FC(F)(F)Oc1ccc(Br)cc1.O.[Cl-].[Na+].[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)OC(=O)N1CCN(C2CCN(c3ccc(OC(F)(F)F)cc3)CC2)CC1",
        "output": "294"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)N1CCC(=O)CC1.ClCCCl.ClCCl.Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1.[Na+]>>CC(C)(C)OC(=O)N1CCC(Nc2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1",
        "output": "469"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1ccc(N)cn1.Cl.ClCCl.O=C(Cl)c1c(F)cc(C(F)(F)F)cc1C(F)(F)F.c1ccncc1>>COC(=O)c1ccc(NC(=O)c2c(F)cc(C(F)(F)F)cc2C(F)(F)F)cn1",
        "output": "501"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CO.COCCOc1ccc(B2OC(C)(C)C(C)(C)O2)cc1.ClCCl.Nc1nc(Nc2cc(Cl)c(Br)c(Cl)c2)n[nH]1.O.O=C([O-])[O-].[K+].[K+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COCCOc1ccc(-c2c(Cl)cc(Nc3n[nH]c(N)n3)cc2Cl)cc1",
        "output": "933"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Fc1ccccn1.O=C([O-])[O-].O=c1c2cc(-c3ccc(OC(F)(F)F)cc3)ccc2cnn1CCCO.[Cs+].[Cs+]>>O=c1c2cc(-c3ccc(OC(F)(F)F)cc3)ccc2cnn1CCCOc1ccccn1",
        "output": "541"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "FC(F)(F)c1c(Cl)ccnc1Cl.OCc1ccccc1>>FC(F)(F)c1c(OCc2ccccc2)ccnc1Cl",
        "output": "651"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(=O)N1CCN(c2ccc([N+](=O)[O-])c(OC3CS(=O)C3)n2)CC1.[Pd]>>CC(=O)N1CCN(c2ccc(N)c(OC3CS(=O)C3)n2)CC1",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.CN(C)C=O.CN1CCC(N)CC1.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(Cc1ccccc1)CCC(=O)N2C.F[P-](F)(F)(F)(F)F.O.O=C([O-])O.[Na+]>>COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(Cc1ccccc1)CCC(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#CCNC1=NC(=O)S/C1=C\\C1CCNCC1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.CN(C)C=O.Cl.Cl.O=C([O-])O.O=Cc1ccc2ccccc2c1.[Na+].[Na+]>>C#CCNC1=NC(=O)S/C1=C\\C1CCN(Cc2ccc3ccccc3c2)CC1",
        "output": "567"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)C(CSC)=NOC.Cl.O.[Na+].[OH-]>>CON=C(CSC)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1nc(Cc2ccccc2-c2ccccc2)[nH]c(=O)c1O.NCCc1ccccc1>>O=C(NCCc1ccccc1)c1nc(Cc2ccccc2-c2ccccc2)[nH]c(=O)c1O",
        "output": "487"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "O.O=S(=O)(O)O.O=[N+]([O-])O.Oc1ccc(F)cn1>>O=[N+]([O-])c1cc(F)cnc1O",
        "output": "328"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCl.N#Cc1ccc(Cc2ccc3c(c2)CCNCC3)nc1.O=C1CCC1.[Na+]>>N#Cc1ccc(Cc2ccc3c(c2)CCN(C2CCC2)CC3)nc1",
        "output": "187"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.N#CCC1COCCO1.O.O=C(NC1CCNCC1)c1n[nH]cc1[N+](=O)[O-]>>CS(=O)(=O)N1CCC(NC(=O)c2n[nH]cc2[N+](=O)[O-])CC1",
        "output": "584"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCN(CC)CCOc1ccc(Br)cc1F.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCN(CC)CCOc1ccc(B2OC(C)(C)C(C)(C)O2)cc1F",
        "output": "942"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.CNc1ccc(C(=O)O)cc1.Cc1ccc2nc(-c3ccc(N)cc3)cn2c1.On1nnc2ccccc21>>CNc1ccc(C(=O)Nc2ccc(-c3cn4cc(C)ccc4n3)cc2)cc1",
        "output": "50"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Cc1ccccc1.Cc1ccccc1C(=O)c1ccc(Nc2ccccc2N)cc1Cl.ClCCl.O=C(O)COc1ccccc1.O=C([O-])O.O=S(Cl)Cl.[Na+]>>Cc1ccccc1C(=O)c1ccc(Nc2ccccc2NC(=O)COc2ccccc2)cc1Cl",
        "output": "365"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CCOCC1.C[C@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)O.ClCCCl.ClCCl.NCC(=O)OCc1ccccc1.On1nnc2ccccc21>>C[C@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)NCC(=O)OCc1ccccc1",
        "output": "132"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Cl.CCN(C(C)C)C(C)C.ClCCl.NC1CCC(Nc2nc(-c3ccc(N4CCOCC4)cc3)cc3ncccc23)CC1>>CC(=O)NC1CCC(Nc2nc(-c3ccc(N4CCOCC4)cc3)cc3ncccc23)CC1",
        "output": "45"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)Cl.ClCCl.Nc1cccc2sccc12.c1ccncc1>>CS(=O)(=O)Nc1cccc2sccc12",
        "output": "194"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CCO[C@@H]1CN(c2cccc(C(=O)OC(C)(C)C)c2)CC[C@@H]1N.CCc1[nH]c(C(=O)O)nc1C(F)(F)F.Cl.On1nnc2ccccc21>>CCO[C@@H]1CN(c2cccc(C(=O)OC(C)(C)C)c2)CC[C@@H]1NC(=O)c1nc(C(F)(F)F)c(CC)[nH]1",
        "output": "951"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)Oc1ccc(Br)cc1F.CCCCCCC.O=C=O.[Li]CCCC>>CC(C)Oc1ccc(C(=O)O)cc1F",
        "output": "654"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCCC(Br)C(=O)OCC.Cc1nc(-c2cccc(O)c2)no1.O=C([O-])[O-].[Cs+].[Cs+]>>CCCC(Oc1cccc(-c2noc(C)n2)c1)C(=O)OCC",
        "output": "455"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(c1ccnc(S(C)=O)n1)c1nccc(-c2ccccc2)n1.CS(C)=O.NCCc1ccccc1>>CN(c1ccnc(NCCc2ccccc2)n1)c1nccc(-c2ccccc2)n1",
        "output": "666"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC1CC(C(=O)NCCNC(=O)c2cn(-c3ccccc3)nc2C(F)(F)F)CCN1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.Cl.O=C(Cl)N1CCCC1>>CC1CC(C(=O)NCCNC(=O)c2cn(-c3ccccc3)nc2C(F)(F)F)CCN1C(=O)N1CCCC1",
        "output": "258"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CCO.CCOc1cc(C=O)cc(OCC)c1F.COc1cc(OCC(N)=O)cc(C(=O)NC2CCNCC2)c1.Cl.[BH3-]C#N.[Na+]>>CCOc1cc(CN2CCC(NC(=O)c3cc(OC)cc(OCC(N)=O)c3)CC2)cc(OCC)c1F",
        "output": "567"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1[nH]c(C=NN=C2C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCC(=O)O.Cl.Nc1ccccc1N.O.Oc1cccc2[nH]nnc12.[Cl-].[Na+]>>Cc1[nH]c(C=NN=C2C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCC(=O)Nc1ccccc1N",
        "output": "365"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "NC(=O)c1ccc(Cl)nc1.O=C([O-])[O-].O=C1CCc2cc(O)ccc21.[K+].[K+]>>NC(=O)c1ccc(Oc2ccc3c(c2)CCC3=O)nc1",
        "output": "516"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.OCCCN1CCOCC1>>CS(=O)(=O)OCCCN1CCOCC1",
        "output": "0"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cccc(CC(=O)O)c1.Cl.Cn1cc(-c2ccc3c(c2)CCN3)c2c(N)ncnc21.F[P-](F)(F)(F)(F)F.O>>COc1cccc(CC(=O)N2CCc3cc(-c4cn(C)c5ncnc(N)c45)ccc32)c1",
        "output": "315"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1=COCCC1.CCOCC.Cc1ccc(S(=O)(=O)OCCC2(O)CC2)cc1.Cc1ccc(S(=O)(=O)[O-])cc1.ClCCl.c1cc[nH+]cc1>>Cc1ccc(S(=O)(=O)OCCC2(OC3CCCCO3)CC2)cc1",
        "output": "306"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)N1CC(O)(c2cc(C#N)cc(N)c2Cl)C1.COc1ccc(CN(c2nc(Cl)nn3c(C#N)cnc23)C2CC2)cc1.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].[Pd+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1ccc(CN(c2nc(Nc3cc(C#N)cc(C4(O)CN(C(=O)OC(C)(C)C)C4)c3Cl)nn3c(C#N)cnc23)C2CC2)cc1",
        "output": "990"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCCCOCc1ccccc1.CC(C)=O.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(=O)C1CCc2ccc(O)cc2O1.O=C([O-])[O-].[I-].[K+].[K+]>>CCOC(=O)C1CCc2ccc(OCCCOCc3ccccc3)cc2O1",
        "output": "75"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCNCC1.Fc1cc(C(F)(F)F)cnc1F.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(c2ncc(C(F)(F)F)cc2F)CC1",
        "output": "756"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N[C@H]1CC[C@@H](N)CC1.COc1cc(Br)ccc1C#N.N#Cc1ccc(Br)cc1F>>CC(C)(C)OC(=O)N[C@H]1CC[C@@H](Nc2ccc(C#N)c(F)c2)CC1",
        "output": "519"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1nc2c(OCc3c(F)cccc3F)cccn2c1-c1cnn(CC(C)(C)[N+](=O)[O-])c1.[Ni]>>Cc1nc2c(OCc3c(F)cccc3F)cccn2c1-c1cnn(CC(C)(C)N)c1",
        "output": "226"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1oc2ccccc2c1C(=O)NCc1ccc2c(Br)c(OC(Cc3ccccc3)C(=O)OC)ccc2c1.CO.Cl.O.[Na+].[OH-]>>CCc1oc2ccccc2c1C(=O)NCc1ccc2c(Br)c(OC(Cc3ccccc3)C(=O)O)ccc2c1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1cc(Cl)ccc1B(O)O.CS(C)=O.Cl[Pd]Cl.O=C([O-])[O-].[Fe+2].[K+].[K+].[O-][n+]1ccc(Cl)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COc1cc(Cl)ccc1-c1cc[n+]([O-])cc1",
        "output": "947"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CC2CCC1CNC2.N#Cc1c(Cl)[nH]c2cccnc12>>N#Cc1c(N2CC3CCC(CC3)C2)[nH]c2cccnc12",
        "output": "296"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2F)cc1NC(=O)CC(=O)c1ccnc(C#N)c1.ClCCl.O=C(O)C(F)(F)F>>N#Cc1cc(C2=Nc3ccc(-c4ccccc4F)cc3NC(=O)C2)ccn1",
        "output": "930"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)OB(OC(C)C)OC(C)C.N#Cc1ccccc1Br.O.[Li]CCCCCC>>N#Cc1ccccc1B(O)O",
        "output": "832"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COCCn1cc(C(=O)O)c2c(Cl)cccc21.F[P-](F)(F)(F)(F)F.NCC1(O)CCC(F)(F)CC1>>COCCn1cc(C(=O)NCC2(O)CCC(F)(F)CC2)c2c(Cl)cccc21",
        "output": "674"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)c1ccc2c(c1)OC1(O)c3cccc([N+](=O)[O-])c3C(=O)C21NC(=O)c1cnc2ccccc2n1.CCO.Cl.O.[Fe]>>CC(C)c1ccc2c(c1)OC1(O)c3cccc(N)c3C(=O)C21NC(=O)c1cnc2ccccc2n1",
        "output": "706"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CCOC(=O)C1C2CN(C(=O)OC(C)(C)C)CC21.CN(C)C=O.CO.ClCCCl.O.On1nnc2ccccc21.[Cl-].[Li+].[NH4+].[OH-]>>CC(C)(C)OC(=O)N1CC2C(C1)C2C(N)=O",
        "output": "163"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CC2(C1)CNC2.CCN(CC)CC.Cl.ClCCl.O=[N+]([O-])c1cccc(S(=O)(=O)Cl)c1>>O=[N+]([O-])c1cccc(S(=O)(=O)N2CC3(CCC3)C2)c1",
        "output": "99"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)CC(O)C(C)Oc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1.CC(=O)Cl.c1ccccc1.c1ccncc1>>CC(=O)CC(OC(C)=O)C(C)Oc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1",
        "output": "126"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.O=C1c2cc(Br)ccc2CC12CCC(O)CC2.c1c[nH]cn1>>CC(C)(C)[Si](OC1CCC2(CC1)Cc1ccc(Br)cc1C2=O)(c1ccccc1)c1ccccc1",
        "output": "602"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN=C=NCCCN(C)C.CN(C)CC(=O)O.Cc1nn(CC(F)(F)CO)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2.Cl.Cl.c1ccncc1>>Cc1nn(CC(F)(F)COC(=O)CN(C)C)c(-c2ccc(F)cc2)c1-c1ccc2c(c1)NC(=O)CO2",
        "output": "17"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[Si](C)(C)Cl.ClCCl.OCCCc1ccncc1Br.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCCc1ccncc1Br",
        "output": "193"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCC(=O)Cl.ClCCl.Fc1cc2nc(COc3ccccc3)n(Cc3ccc(Cl)cc3)c2cc1N1CCNCC1>>CCCCC(=O)N1CCN(c2cc3c(cc2F)nc(COc2ccccc2)n3Cc2ccc(Cl)cc2)CC1",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CC(=O)Cl.CCN(CC)CC.ClCCl.O=S(=O)(c1cccc(C(F)(F)F)c1)N(C1CCNCC1)C1CC1>>C=CC(=O)N1CCC(N(C2CC2)S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1",
        "output": "135"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)[C@@H]1CC[C@@H](O)CC1.CN(C)C=O.C[Si](C)(C)Cl.c1c[nH]cn1>>CCOC(=O)[C@@H]1CC[C@@H](O[Si](C)(C)C)CC1",
        "output": "193"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N[C@H](CCO[Si](C)(C)C(C)(C)C)C(=O)O.CCOC(C)=O.CN(C)c1ccncc1.ClCCCl.ClCCl.OC1CCCC1>>CC(C)(C)OC(=O)N[C@H](CCO[Si](C)(C)C(C)(C)C)C(=O)OC1CCCC1",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COC(=O)/C(=C/c1ccc(C)o1)CC(=O)OC(C)(C)C.Cc1ccccc1.O.O=C(O)C(F)(F)F>>COC(=O)/C(=C/c1ccc(C)o1)CC(=O)O",
        "output": "278"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)c1ccccc1B1OC(C)(C)C(C)(C)O1.Cc1ccc(S(=O)(=O)OCC2Cc3cc(Br)cc(F)c3O2)cc1.Cc1ccccc1B(O)O>>Cc1ccc(S(=O)(=O)OCC2Cc3cc(-c4ccccc4C)cc(F)c3O2)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(F)c(F)c1.OC[C@H]1CCCN1.[K+].[K+]>>O=[N+]([O-])c1ccc(N2CCC[C@@H]2CO)c(F)c1",
        "output": "26"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCC(=O)Cl.Cn1c(=O)c(-c2ccc(F)cc2)cc2c3ccccc3n(C)c21>>CCC(=O)c1ccc2c(c1)c1cc(-c3ccc(F)cc3)c(=O)n(C)c1n2C",
        "output": "31"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=CCCO)CCCC(C)CCCC(C)CCCC(C)C.CCN(CC)CC.CN(C)C.CN(C)CCCN.Cc1ccc(S(=O)(=O)Cl)cc1.Cl.ClCCl.O>>CC(=CCCOS(=O)(=O)c1ccc(C)cc1)CCCC(C)CCCC(C)CCCC(C)C",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(-c2ccccc2)nc1NC(=O)c1ccc(CNC(=O)OCc2ccccc2)cc1.ClCCl.O=C(O)C(F)(F)F>>Nc1ccc(-c2ccccc2)nc1NC(=O)c1ccc(CNC(=O)OCc2ccccc2)cc1",
        "output": "877"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CNCCNC.Cc1ccc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(CC3CC3)cc(C=O)c2c1>>CNCCN(C)Cc1cn(CC2CC2)c(=O)c2ccc(-c3cc(C(=O)NC4CC4)ccc3C)cc12",
        "output": "757"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN.ClCCl.O.O=C(/N=c1\\[nH]c2ccc(CN3CCCCC3)cc2n1[C@@H]1CC[C@H](C(=O)O)CC1)c1ccc(F)cc1.O=S(Cl)Cl>>CCNC(=O)[C@@H]1CC[C@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CCCCC4)cc32)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCOCCCCCCCCN.CCOC(C)=O.CN1CCCC1=O.FC(F)(F)c1cc(Cl)c2ccccc2n1>>CCCCCCOCCCCCCCCNc1cc(C(F)(F)F)nc2ccccc12",
        "output": "78"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1c[nH]cc1-c1cccc(Cl)c1Cl.Cl>>O=C(O)c1c[nH]cc1-c1cccc(Cl)c1Cl",
        "output": "152"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Nc1cc(Oc2cnc([N+](=O)[O-])cc2C)ccn1.CCOC(C)=O.[Pd]>>CC(=O)Nc1cc(Oc2cnc(N)cc2C)ccn1",
        "output": "457"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)[C@@H](OC(C)(C)C)c1c(C)nc(C)c(-c2ccc(OCC)cc2)c1N1CCC(C)(C)CC1.O.[Li+].[OH-]>>CCOc1ccc(-c2c(C)nc(C)c([C@H](OC(C)(C)C)C(=O)O)c2N2CCC(C)(C)CC2)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCC(=O)Cl.CCN1CCC(c2c[nH]c3ccc(N)nc23)CC1>>CCC(=O)Nc1ccc2[nH]cc(C3CCN(CC)CC3)c2n1",
        "output": "332"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)CBr.O=C([O-])[O-].Oc1ccc2cc(-c3ccc(-c4ccccc4)n3Cc3ccc(C(F)(F)F)cc3)ccc2c1.[Cs+].[Cs+]>>COC(=O)COc1ccc2cc(-c3ccc(-c4ccccc4)n3Cc3ccc(C(F)(F)F)cc3)ccc2c1",
        "output": "557"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.Cc1cc(CC(=O)O)on1.O=S(=O)(O)O>>CCOC(=O)Cc1cc(C)no1",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(=O)C12CC3CC(CC(C3)C1)C2.CC(C)NC(C)C.O=Cc1ccncc1.[Li]CCCC>>O=C(/C=C/c1ccncc1)C12CC3CC(CC(C3)C1)C2",
        "output": "656"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCC(=O)Nc1cc(Cl)cc(C#N)c1.COc1ccc(CBr)cc1>>CCCCC(=O)N(Cc1ccc(OC)cc1)c1cc(Cl)cc(C#N)c1",
        "output": "688"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.ClCCCCBr.O.O=c1ccc2ccccc2[nH]1.[H-].[Na+]>>O=c1ccc2ccccc2n1CCCCCl",
        "output": "470"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)C[C@@H](C(=O)NN1CC(=O)NC1=O)[C@H](C/C=C/c1ccccc1)C(=O)NOC1CCCCO1.CCOC(C)=O.CO.Cc1ccc(S(=O)(=O)O)cc1.O>>CC(C)C[C@@H](C(=O)NN1CC(=O)NC1=O)[C@H](C/C=C/c1ccccc1)C(=O)NO",
        "output": "915"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccccc1.O.O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl.O=C([O-])[O-].O=S(Cl)Cl.OCCOCCOCCO.[K+].[K+]>>O=C(Cc1ccccc1Nc1c(Cl)cccc1Cl)OCCOCCOCCO",
        "output": "47"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CC(C)(N)c1nnc(C2CC2)n1C1CC1.ClC(Cl)Cl.O.O=C1OC(=O)c2c(Br)cccc21.[Na+].[OH-]>>CC(C)(c1nnc(C2CC2)n1C1CC1)N1C(=O)c2ccc(Br)cc2C1=O",
        "output": "341"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cccc(Cc2c(-c3ccccc3)nn3cc(CCO)ccc23)n1.Cl.[K+].[OH-]>>O=C(O)c1cccc(Cc2c(-c3ccccc3)nn3cc(CCO)ccc23)n1",
        "output": "152"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COC(=O)c1ccc(C)c(-n2cnc(OCc3ccc(F)cc3F)cc2=O)c1.[Na+].[OH-]>>Cc1ccc(C(=O)O)cc1-n1cnc(OCc2ccc(F)cc2F)cc1=O",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.C1COCCO1.CC(=O)[O-].CO.COC(=O)[C@H]1[C@H](c2ccc(Br)cc2)[C@H]1c1ccccc1.Cc1cc[nH]n1.Cl[Pd]Cl.O.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>COC(=O)[C@H]1[C@H](c2ccc(-n3ccc(C)n3)cc2)[C@H]1c1ccccc1",
        "output": "919"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "ClCCCl.ClCCl.NC1CCc2cc(CN3CCCCC3)ccc2C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1.On1nnc2ccccc21>>O=C(CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NC1CCc2cc(CN3CCCCC3)ccc2C1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOC(=O)CCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1.Cl.O.[K+].[OH-]>>O=C(O)CCN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCc1c(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n(CC(=O)C(C)(C)C)c2ncnn12.CCOC(C)=O.CS(C)=O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCc1c(Cc2ccc(-c3ccccc3-c3noc(=O)[nH]3)cc2)c(=O)n(CC(=O)C(C)(C)C)c2ncnn12",
        "output": "979"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.Cc1ccc(C)c(Cl)c1.O=S(=O)(O)O.O=[N+]([O-])O>>Cc1cc([N+](=O)[O-])c(C)cc1Cl",
        "output": "21"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.N#Cc1ccccc1-c1ccc(COCc2ccc(Cl)nc2)cc1.NN.O>>N#Cc1ccccc1-c1ccc(COCc2ccc(NN)nc2)cc1",
        "output": "417"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CS(=O)(=O)C1CCC2(CC1)OCCO2.Cl>>CS(=O)(=O)C1CCC(=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.Nc1ccc(N2CCCC2=O)cc1.O=C1CCC(=O)N1Cl>>Nc1ccc(N2CCCC2=O)cc1Cl",
        "output": "121"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "N#CC1(Nc2ccccc2)CCN(CC2=Cc3ccccc3CC2)CC1.O=S(=O)(O)O.[NH4+].[OH-]>>NC(=O)C1(Nc2ccccc2)CCN(CC2=Cc3ccccc3CC2)CC1",
        "output": "8"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3)cc2n(-c2ccc(OC)cc2)c1=O.NCCO>>COc1ccc(-n2c(=O)c(C(=O)NCCO)c(O)c3ncc(Cc4ccc(F)cc4)cc32)cc1",
        "output": "862"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1C[C@@H](CO)C1.ClCCl>>CC(C)(C)OC(=O)N[C@H]1C[C@H](C=O)C1",
        "output": "142"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.COC(=O)C(C[C@H]1CCCO1)c1ccc(S(C)(=O)=O)c(Cl)c1.O.O.[Li+].[OH-]>>CS(=O)(=O)c1ccc(C(C[C@H]2CCCO2)C(=O)O)cc1Cl",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC(CCC)COc1cccc(C[C@H](O)CCl)c1.[N-]=[N+]=[N-].[Na+]>>CCCC(CCC)COc1cccc(C[C@H](O)CN=[N+]=[N-])c1",
        "output": "243"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.Cl.O=C1CCC2(CC1)CCC(=O)CC2.[BH4-].[Na+]>>O=C1CCC2(CC1)CCC(O)CC2",
        "output": "91"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CNCCCN(C)C.CS(C)=O.Cl.O.O=[N+]([O-])c1ccc(F)cc1.[K+].[OH-]>>CN(C)CCCN(C)c1ccc([N+](=O)[O-])cc1",
        "output": "26"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc(C)c1O.O=S1CCN(C2CCNCC2)CC1>>Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCS(=O)CC3)CC2)cc(C)c1O",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(C)=O.Cl.O=C1N(c2cccc(Cl)c2)CCC12CCCC1(C2)OCCO1>>O=C1CCCC2(CCN(c3cccc(Cl)c3)C2=O)C1",
        "output": "251"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN1CCCC1=O.Fc1ncccc1C1CCCOCC1.O.O=C([O-])[O-].O=C(c1ccc(O)cc1)c1nc2ccccc2[nH]1.[Cs+].[Cs+]>>O=C(c1ccc(Oc2ncccc2C2CCCOCC2)cc1)c1nc2ccccc2[nH]1",
        "output": "727"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCNC(=O)C1(CO)CC1.N#Cc1c(N)cccc1F.[H-].[Na+]>>CCCNC(=O)C1(COc2cccc(N)c2C#N)CC1",
        "output": "485"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.OCCC1(O)CC1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCCC2(O)CC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)C1=C(O)C=C2Oc3c(C(N)=O)c(OCc4ccccc4)cc(O)c3[C@]2(C)C1=O.CC[SiH](CC)CC.Cc1ccccc1.O=C(O)C(F)(F)F.O=Cc1ccccc1>>CC(=O)C1=C(O)C=C2Oc3c(C(=O)NCc4ccccc4)c(OCc4ccccc4)cc(O)c3[C@]2(C)C1=O",
        "output": "996"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1(N2CCC(N3C(=O)N[C@H]4CCCC[C@@H]43)CC2)CCNC1.O.O=C(Cl)OCCF.O=C([O-])[O-].[K+].[K+]>>CC1(N2CCC(N3C(=O)N[C@H]4CCCC[C@@H]43)CC2)CCN(C(=O)OCCF)C1",
        "output": "219"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN1CCC(O)CC1.Nc1nonc1-c1nc2cnccc2n1-c1cccc(O)c1>>CN1CCC(Oc2cccc(-n3c(-c4nonc4N)nc4cnccc43)c2)CC1",
        "output": "846"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCc1cc2[nH]c(C)nn2n1.CCCc1cc2nc(C)nn2n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>CCCc1cc2nc(C)nn2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1",
        "output": "815"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.COC(=O)C(CCCc1ccccc1)CCc1ccc(N)cc1.ClCCCl.O.O=Cc1ccccc1.[Na+]>>COC(=O)C(CCCc1ccccc1)CCc1ccc(NCc2ccccc2)cc1",
        "output": "359"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCN1CCN(c2nc(C)c(C(=O)O)s2)C1=O.Cc1nc(N2CCN(Cc3ccccc3)C2=O)sc1C(=O)O.NCc1cccnc1>>CCCCN1CCN(c2nc(C)c(C(=O)NCc3cccnc3)s2)C1=O",
        "output": "534"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCC.CCO.CCOC(C)=O.COc1ccc([N+](=O)[O-])nc1Br.O.O=S([O-])S(=O)[O-].[NH4+].[Na+].[Na+].[OH-]>>COc1ccc(N)nc1Br",
        "output": "457"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=[N+]([O-])c1cnccc1Cl.OCc1ccc(C(F)(F)F)cc1>>O=[N+]([O-])c1cnccc1OCc1ccc(C(F)(F)F)cc1",
        "output": "651"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.COC(=O)[C@H](Cc1c[nH]cn1)NC(=O)OC(C)(C)C.FC(F)(F)CCCBr.O=C([O-])[O-].[Cs+].[Cs+]>>COC(=O)[C@H](Cc1cn(CCCC(F)(F)F)cn1)NC(=O)OC(C)(C)C",
        "output": "276"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CCOC(=O)C1=Cc2cc(O)cc(Cl)c2OC1C(F)(F)F.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)C1=Cc2cc(OCc3ccccc3)cc(Cl)c2OC1C(F)(F)F",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CCO.CP(C)(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Cl)n2)cc1.NCC12CC3CC(CC(C3)C1)C2>>CP(C)(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCC34CC5CC(CC(C5)C3)C4)n2)cc1",
        "output": "166"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N(C)C.CCOc1nc(C(=O)O)cc(N)c1C#N.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F.NCc1cccc(N)c1>>CCOc1nc(C(=O)NCc2cccc(N)c2)cc(N)c1C#N",
        "output": "905"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)c1cc(O)cc(O)c1.CO.Cl.[H][H].[Pd]>>CCc1cc(O)cc(O)c1",
        "output": "92"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.O.O=C([O-])[O-].O=c1c(Cc2cccnc2)cn2c3cc(Br)ccc3c(=O)c3cc(O)cc1c32.OCCCBr.[K+].[K+]>>O=c1c(Cc2cccnc2)cn2c3cc(Br)ccc3c(=O)c3cc(OCCCO)cc1c32",
        "output": "75"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)c1cccc(CBr)c1.Clc1cc2c(NC3CCNCC3)ncnc2s1>>CS(=O)(=O)c1cccc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)c1",
        "output": "248"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COC(=O)/C=C/c1ccc(-c2ccc(O)c(C34CC5CC(CC(C5)C3)C4)c2)cc1.Cl.ClCCN1CCOCC1.O=C([O-])[O-].[K+].[K+]>>COC(=O)/C=C/c1ccc(-c2ccc(OCCN3CCOCC3)c(C34CC5CC(CC(C5)C3)C4)c2)cc1",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)O)CC2)nc1OC.NS(=O)(=O)Cc1ccc(Cl)cc1>>CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccc(Cl)cc3)CC2)nc1OC",
        "output": "644"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(C)=O.CO.NC1CCN(c2nc3ccc(Cl)cc3s2)CC1>>CC(C)NC1CCN(c2nc3ccc(Cl)cc3s2)CC1",
        "output": "236"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCN(CC)c1cccc2nc3n(c12)CC(N=[N+]=[N-])CCN3c1ccc(Cl)cc1Cl.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>CCN(CC)c1cccc2nc3n(c12)CC(N)CCN3c1ccc(Cl)cc1Cl",
        "output": "89"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "NC1(CN2C(=O)S/C(=C\\c3ccc4c(cnn4Cc4ccc(C(F)(F)F)cc4C(F)(F)F)c3)C2=O)CCOCC1.O=C(Cl)C1CC1>>O=C(NC1(CN2C(=O)S/C(=C\\c3ccc4c(cnn4Cc4ccc(C(F)(F)F)cc4C(F)(F)F)c3)C2=O)CCOCC1)C1CC1",
        "output": "45"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCC.CCO.CCOC(C)=O.ClCCCc1nnn[nH]1.O.Oc1cccc(OCc2ccc3ccccc3n2)c1.[K+].[OH-]>>c1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1",
        "output": "74"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)N(C)c1ccc(S(=O)(=O)Cl)cc1.CC(=O)[O-].CCO.Cl.NC1Cc2ccccc2C1.O.[Na+]>>CC(=O)N(C)c1ccc(S(=O)(=O)NC2Cc3ccccc3C2)cc1",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCn1c(=O)n(-c2ccc(OCc3ccccc3)cc2)c2ncc(OC(F)F)cc21.CO.[Pd]>>CCn1c(=O)n(-c2ccc(O)cc2)c2ncc(OC(F)F)cc21",
        "output": "698"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(Cl)OC(=O)Cl.Cc1cc(Cl)cc(C2(C(F)(F)F)CCN(Cc3ccccc3)C2)c1.ClCCl>>Cc1cc(Cl)cc(C2(C(F)(F)F)CCNC2)c1",
        "output": "84"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)Nc1c(C)c([N+](=O)[O-])cc(CC)c1C(=O)OCC.[H][H].[Pd]>>CCOC(=O)Nc1c(C)c(N)cc(CC)c1C(=O)OCC",
        "output": "772"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)N(C)C.CC(C)(C)[O-].CC(C)c1cc(Cl)nnc1Cl.O.OCCCc1cc(Br)c(O)c(Br)c1.[K+]>>CC(C)c1cc(Oc2c(Br)cc(CCCO)cc2Br)nnc1Cl",
        "output": "603"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)C1CCCc2sc(=O)[nH]c21.Cl.O.[Na+].[OH-]>>O=C(O)C1CCCc2sc(=O)[nH]c21",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)=O.CCCCCCBr.CCCC[N+](CCCC)(CCCC)CCCC.Cn1cc(-c2cn(COCC[Si](C)(C)C)c3ncc(O)cc23)cn1.O=C([O-])[O-].[I-].[K+].[K+]>>CCCCCCOc1cnc2c(c1)c(-c1cnn(C)c1)cn2COCC[Si](C)(C)C",
        "output": "608"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)C(CC1CCCC1)c1ccc([N+](=O)[O-])cc1.CCOC(C)=O.[Pd]>>CCOC(=O)C(CC1CCCC1)c1ccc(N)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Nc1cccc2c(CC(=O)O)cccc12.O=Cc1cccc(-c2c(Cc3ccccc3)cnc3c(C(F)(F)F)cccc23)c1>>O=C(O)Cc1cccc2c(NCc3cccc(-c4c(Cc5ccccc5)cnc5c(C(F)(F)F)cccc45)c3)cccc12",
        "output": "359"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccccc1NC1CCOCC1.[Pd]>>Nc1ccccc1NC1CCOCC1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCCc2c(ccc(N3CC[C@H](N)C3=O)c2F)C1.CC(C)(C)OC(=O)N1CCCc2cc(N3CC[C@H](NS(=O)(=O)/C=C/c4ccc(Cl)s4)C3=O)ccc2C1.O=S(=O)(Cl)c1ccc2cc(Cl)ccc2c1>>CC(C)(C)OC(=O)N1CCCc2c(ccc(N3CC[C@H](NS(=O)(=O)c4ccc5cc(Cl)ccc5c4)C3=O)c2F)C1",
        "output": "596"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCN1CC(c2ccc(N)cc2)C1.O=S(=O)(Cl)c1cccs1>>CCCN1CC(c2ccc(NS(=O)(=O)c3cccs3)cc2)C1",
        "output": "861"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Cl.ClCCl.Clc1ccc2c(c1-c1[nH]nnc1-c1ccccc1)CCNCC2.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N1CCc2ccc(Cl)c(-c3[nH]nnc3-c3ccccc3)c2CC1",
        "output": "694"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCC(CN)(c2cccc(F)c2)CC1.N#Cc1cc(C(=O)Cl)c2ccccc2c1>>CN1CCC(CNC(=O)c2cc(C#N)cc3ccccc23)(c2cccc(F)c2)CC1",
        "output": "271"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(O)CCNc1cc(-n2c3ccccc3c3c(-c4ccc(C#N)nc4)cccc32)ccc1C(=O)O.CCN(C(C)C)C(C)C.CN(C)C=O.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F.O.Oc1cccc2[nH]nnc12.[Cl-].[NH4+]>>CC(C)(O)CCNc1cc(-n2c3ccccc3c3c(-c4ccc(C#N)nc4)cccc32)ccc1C(N)=O",
        "output": "358"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCNCCC.CCN(C(C)C)C(C)C.CN(C)C=O.COc1ccc2cc(C(=O)c3ccccc3)cc(CC(=O)O)c2c1.ClCCCl.On1nnc2ccccc21>>CCCN(CCC)C(=O)Cc1cc(C(=O)c2ccccc2)cc2ccc(OC)cc12",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)O)ccc21.F[P-](F)(F)(F)(F)F.NCCCCCO>>Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)NCCCCCO)ccc21",
        "output": "334"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)C3=CC[C@]12C.O.c1ccncc1>>CC(=O)O[C@@H]1CC[C@]2(C)C3=CC[C@]4(C)[C@@H](C(C)=O)CC[C@H]4[C@@H]3CC[C@H]2C1",
        "output": "254"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc2nc(N3CCC(Nc4ccc(C(=O)OC(C)(C)C)cc4)CC3)[nH]c(=O)c2cc1OC.O=C(O)C(F)(F)F>>COc1cc2nc(N3CCC(Nc4ccc(C(=O)O)cc4)CC3)[nH]c(=O)c2cc1OC",
        "output": "752"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)CC(=O)Cl.CS(=O)(=O)c1ccc(Oc2ncnc3c2cnn3C2CCNCC2)cc1.O=C(O)C(F)(F)F>>CC(C)(C)CC(=O)N1CCC(n2ncc3c(Oc4ccc(S(C)(=O)=O)cc4)ncnc32)CC1",
        "output": "125"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(=O)C1CCN(c2ncccc2[N+](=O)[O-])CC1.CO.Cl.O.[K+].[OH-]>>O=C(O)C1CCN(c2ncccc2[N+](=O)[O-])CC1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCCl.NC(=O)c1cc(CO)on1.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.c1ccncc1>>NC(=O)c1cc(COC(=O)Oc2ccc([N+](=O)[O-])cc2)on1",
        "output": "662"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Clc1ccc(N2CCNCC2)cc1.F[P-](F)(F)(F)(F)F.O.[N-]=[N+]=NCc1c(Cl)c(C(F)(F)F)nn1CC(=O)O>>[N-]=[N+]=NCc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(Cl)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)OC(C)=O.Nc1nc(-c2ccccc2)c(CCO)c2ncnn12.c1ccncc1>>CC(=O)OCCc1c(-c2ccccc2)nc(N)n2ncnc12",
        "output": "254"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)Cc3csc(-c4ccccc4O)n3)C2SC1.CC[SiH](CC)CC.ClCCCl.O=C(Cc1csc(-c2cccc(O)c2)n1)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=CCSC12.O=C(O)C(F)(F)F>>O=C(Cc1csc(-c2cccc(O)c2)n1)NC1C(=O)N2C(C(=O)O)=CCSC12",
        "output": "228"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CC(CO)C(c2ccc(COCCOCc3ccccc3)cc2)C(OCc2ccc3ccccc3c2)C1.COCCBr>>COCCOCC1CN(C(=O)OC(C)(C)C)CC(OCc2ccc3ccccc3c2)C1c1ccc(COCCOCc2ccccc2)cc1",
        "output": "95"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCCn1cc(C2CCC(=O)CC2)c2cc(C#N)ccc21.ClCCCl.[Na+].c1cc(N2CCNCC2)c2cc[nH]c2c1>>CCCn1cc(C2CCC(N3CCN(c4cccc5[nH]ccc45)CC3)CC2)c2cc(C#N)ccc21",
        "output": "187"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CCO.COC(=O)C[C@@H]1Cc2ccc(OCCCNC3=NCCCN3)cc2CN(Cc2ccc(C(F)(F)F)cc2)C1=O.Cl.O.[Na+].[OH-]>>O=C(O)C[C@@H]1Cc2ccc(OCCCNC3=NCCCN3)cc2CN(Cc2ccc(C(F)(F)F)cc2)C1=O",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.COc1cc(CBr)c(Cl)cc1Cl.ClCCl.O.[Br-].[C-]#N.[K+]>>COc1cc(CC#N)c(Cl)cc1Cl",
        "output": "39"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.COC(=O)c1cc2ccc(OC)cc2s1.ClCCl>>COC(=O)c1cc2ccc(O)cc2s1",
        "output": "48"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC1CO1.CCOC(C)=O.O.Oc1cccc(C(F)(F)F)c1.[Li+].[OH-]>>CCC(O)COc1cccc(C(F)(F)F)c1",
        "output": "277"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)c1nc2cc(CCl)ccc2o1.Oc1ccc(CCCn2ccnc2)cc1>>CC(C)c1nc2cc(COc3ccc(CCCn4ccnc4)cc3)ccc2o1",
        "output": "49"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1ccc(SCCCCOc2ccc3c(c2)C(C)(C)OC(=O)N3)cc1.OO>>Cc1ccc(S(=O)CCCCOc2ccc3c(c2)C(C)(C)OC(=O)N3)cc1",
        "output": "199"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.C[C@H](NC(=O)c1cccn1N)c1ccccc1>>C[C@H](NC(=O)c1cccn1NC(=O)CNC(=O)OC(C)(C)C)c1ccccc1",
        "output": "459"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=C(NC1(Cc2ccc(OCc3ccccc3)cc2)CCCCN(Cc2ccccc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1.[Pd]>>O=C(NC1(Cc2ccc(O)cc2)CCCCN(Cc2ccccc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "NCCc1ccc(CN2CC=CC2)c(Br)c1.O=C(O)c1ccc(-c2ccc(Br)cc2)cc1F>>O=C(NCCc1ccc(CN2CC=CC2)c(Br)c1)c1ccc(-c2ccc(Br)cc2)cc1F",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1nc(Cl)c([N+](=O)[O-])c(Cl)n1.O=C([O-])[O-].OB(O)c1ccccc1C(F)(F)F.[Na+].[Na+].c1ccccc1>>Cc1nc(Cl)c([N+](=O)[O-])c(-c2ccccc2C(F)(F)F)n1",
        "output": "884"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1noc(C)c1S(=O)(=O)N1CCC2(CCNC2=O)CC1.OC(c1ccc(I)cc1)C(F)(F)F>>Cc1noc(C)c1S(=O)(=O)N1CCC2(CCN(c3ccc(C(O)C(F)(F)F)cc3)C2=O)CC1",
        "output": "921"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc(OC2CCN(C)CC2)c2c(Cl)ncnc2c1.Nc1ccc2[nH]ccc2c1>>COc1cc(OC2CCN(C)CC2)c2c(Nc3ccc4[nH]ccc4c3)ncnc2c1",
        "output": "161"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CO.O.O=[N+]([O-])c1ccc(Sc2ccc(F)cc2)cc1.[Cl-].[Fe].[NH4+]>>Nc1ccc(Sc2ccc(F)cc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.C[Si](C)(C)C#CCc1cn(C[C@H]2CN(c3ccc(C4=CCS(=O)(=O)CC4)c(F)c3)C(=O)O2)nn1.Cl.[K+].[OH-]>>C#CCc1cn(C[C@H]2CN(c3ccc(C4=CCS(=O)(=O)CC4)c(F)c3)C(=O)O2)nn1",
        "output": "337"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)Cl)cc1.CNC(C)c1nc2c(C)cccc2c(=O)n1-c1ccc(OC)cc1>>COc1ccc(-n2c(C(C)N(C)S(=O)(=O)c3ccc(C(C)(C)C)cc3)nc3c(C)cccc3c2=O)cc1",
        "output": "99"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)(C)[O-].CCCC[N+](CCCC)(CCCC)CCCC.COc1ccc(CCl)cc1.O=[N+]([O-])c1cccc2[nH]nc(I)c12.[I-].[K+]>>COc1ccc(Cn2nc(I)c3c([N+](=O)[O-])cccc32)cc1",
        "output": "842"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)CNC(=O)Cc1cccc2[nH]c(=O)n(-c3cccc(S(=O)(=O)N4CCCc5ccccc54)c3)c(=O)c12.ClCCl.O=C(O)C(F)(F)F>>O=C(O)CNC(=O)Cc1cccc2[nH]c(=O)n(-c3cccc(S(=O)(=O)N4CCCc5ccccc54)c3)c(=O)c12",
        "output": "278"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC12COCCN1c1nc(Cl)ncc1N(C1CCSCC1)C2=O.CO.O.O=S([O-])OO.[K+]>>CC12COCCN1c1nc(Cl)ncc1N(C1CCS(=O)(=O)CC1)C2=O",
        "output": "847"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)Cl.CCc1c(C)nc(-c2ccc(Cl)s2)nc1Nc1ccc(Br)c(CO)c1.CN(C)c1ccncc1.O.c1ccncc1>>CCc1c(C)nc(-c2ccc(Cl)s2)nc1Nc1ccc(Br)c(COC(C)=O)c1",
        "output": "126"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Fc1cc(CBr)cc(C(Cl)=C(Cl)Cl)c1.[N-]=[N+]=[N-].[Na+]>>[N-]=[N+]=NCc1cc(F)cc(C(Cl)=C(Cl)Cl)c1",
        "output": "643"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCC(C#Cc1cccc(Cl)c1)N1CCNCC1.CCN(CC)CC.COCCOC(=O)Cl.ClCCl>>CCC(C#Cc1cccc(Cl)c1)N1CCN(C(=O)OCCOC)CC1",
        "output": "219"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CC(=O)c1cccc([N+](=O)[O-])c1.[Br-].[Br-].[Br-].c1cc[nH+]cc1.c1cc[nH+]cc1.c1cc[nH+]cc1>>O=C(CBr)c1cccc([N+](=O)[O-])c1",
        "output": "360"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CCOC(C)=O.COc1cc(N)ccc1-n1cnc(C)c1.FC(F)(F)COCc1cc(OCC2CC2)nc(Cl)n1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1ccc(-c2ccccc2P(C2CCCCC2)C2CCCCC2)cc1>>COc1cc(Nc2nc(COCC(F)(F)F)cc(OCC3CC3)n2)ccc1-n1cnc(C)c1",
        "output": "808"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNCC1.CCO.O=C(O)c1ccc([N+](=O)[O-])c(F)c1>>O=C(O)c1ccc([N+](=O)[O-])c(N2CCCCC2)c1",
        "output": "26"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O.O=C(N[C@@H]1CCCC[C@H]1CNCCCc1ccc(F)cc1)OCc1ccccc1>>CC(C)(C)OC(=O)N(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1NC(=O)OCc1ccccc1",
        "output": "694"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)Cc1nccn1CCCCc1ccc(O)cc1.Fc1ccc(/C=C/c2nc(CCl)co2)c(Cl)c1.[H-].[Na+]>>CS(=O)(=O)Cc1nccn1CCCCc1ccc(OCc2coc(/C=C/c3ccc(F)cc3Cl)n2)cc1",
        "output": "760"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.COC(=O)c1c(C)[nH]c2cc(Cl)ccc12.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1c(C)n(C)c2cc(Cl)ccc12",
        "output": "191"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.CCC(C)(C)O.Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1.[Cl-].[Cl-].[Zn+2]>>c1ccc(-c2cc(N3CCCC3)cc(-c3ccccn3)n2)nc1",
        "output": "398"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCc1nc(C)n(-c2ccc3c(c2)C(O)CC(C)(C)O3)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CI.CN(C)C=O.O=S(=O)([O-])O.[H-].[K+].[Na+]>>CCCc1nc(C)n(-c2ccc3c(c2)C(OC)CC(C)(C)O3)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "140"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC[N+](CC)(CC)Cc1ccccc1.COC(=O)c1c(C)[nH]c2ncc(Br)cc12.ClCCl.O=S(=O)(Cl)c1ccccc1.[Cl-].[Na+].[OH-]>>COC(=O)c1c(C)n(S(=O)(=O)c2ccccc2)c2ncc(Br)cc12",
        "output": "354"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCCC1(COCc1ccccc1)C(=O)O.CO.[Pd]>>CC(C)(C)OC(=O)N1CCCC1(CO)C(=O)O",
        "output": "178"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.Cc1ccc(S(=O)(=O)Cl)cc1.OCC1CCOC1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCC2CCOC2)cc1",
        "output": "197"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCn1c2c(c3cc([N+](=O)[O-])ccc31)CCCC2.CCOC(C)=O.CO.[H][H].[Pd]>>CCCn1c2c(c3cc(N)ccc31)CCCC2",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.Cc1ccccc1.Cl.O.O=C([O-])[O-].O=C1CCCc2[nH]c3ncc(Br)cc3c21.OB(O)c1ccccc1.[Na+].[Na+]>>O=C1CCCc2[nH]c3ncc(-c4ccccc4)cc3c21",
        "output": "833"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)Cl.CC(=O)c1cc2c(s1)-c1ccccc1CC2.Cl.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CC(=O)c1ccc2c(c1)CCc1cc(C(C)=O)sc1-2",
        "output": "31"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCC(C(=O)OC)c1c(-c2ccccc2)nc2sc3c(c2c1-c1ccc(C)cc1)CCC3.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(-c2ccccc2)nc2sc3c(c2c1-c1ccc(C)cc1)CCC3",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.O=C1CCC(=O)O1.O=[N+]([O-])c1ccccc1.Oc1cccc(O)c1.[Al+3].[Cl-].[Cl-].[Cl-]>>O=C(O)CCC(=O)c1ccc(O)cc1O",
        "output": "345"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CS(=O)(=O)Cl.Nc1ccc(O)cc1F.c1ccncc1>>CS(=O)(=O)Nc1ccc(O)cc1F",
        "output": "194"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCN(CCCN)CC2)c1.O=C(O)C1(c2ccc(Cl)cc2)CCCCC1>>CC(C)C(=O)Nc1cccc(C2CCN(CCCNC(=O)C3(c4ccc(Cl)cc4)CCCCC3)CC2)c1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)CNc1cc(Cl)c(Cl)cc1O.Cl.O.O.[Li]O>>O=C(O)CNc1cc(Cl)c(Cl)cc1O",
        "output": "7"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.Cc1cc(CNC(=O)[C@@H]2C[C@@H](F)CN2C(=O)OC(C)(C)C)cc(-c2cnc(C(F)(F)F)nc2)n1.Cl>>Cc1cc(CNC(=O)[C@@H]2C[C@@H](F)CN2)cc(-c2cnc(C(F)(F)F)nc2)n1",
        "output": "634"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCO.COc1cc(C=O)c([N+](=O)[O-])cc1OC.Cl.O.[Fe]>>COc1cc(N)c(C=O)cc1OC",
        "output": "202"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)/C(=C/c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)OCC.CCOC(C)=O.CNc1cccc(Br)n1.COCCOCCOC.Cl[Pd]Cl.O.[Cs+].[F-].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOC(=O)/C(=C/c1ccc(-c2cccc(NC)n2)cc1)OCC",
        "output": "939"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CCN1CCNCC1.O=C([O-])[O-].O=[N+]([O-])c1ccc(CCl)cc1.[K+].[K+]>>CCN1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1",
        "output": "156"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)C(=O)Nc1cccc(C2CCNCC2)c1.O=Cc1cccc(Oc2ccccc2)c1>>CC(C)C(=O)Nc1cccc(C2CCN(Cc3cccc(Oc4ccccc4)c3)CC2)c1",
        "output": "567"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CO.COC(=O)CC1C(=O)N(Cc2ccc(NS(C)(=O)=O)cc2)c2ccccc2N(c2ccc(CNC(=O)OC(C)(C)C)cc2)C1=O.O.O=S(=O)([O-])O.[K+].[Na+].[OH-]>>CC(C)(C)OC(=O)NCc1ccc(N2C(=O)C(CC(=O)O)C(=O)N(Cc3ccc(NS(C)(=O)=O)cc3)c3ccccc32)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCC12CC(=O)C=C1c1ccc(O)cc1C2.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C=O.COCCl>>CCCCC12CC(=O)C=C1c1ccc(OCOC)cc1C2",
        "output": "375"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.CCCCCC.COC(=O)c1ccc(C)nc1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>COC(=O)c1ccc(CBr)nc1",
        "output": "590"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)OB(c2ccc(-c3cnc4[nH]ccc4c3)c(F)c2)OC1(C)C.Nc1ccnc(Oc2ccccc2Br)n1>>Nc1ccnc(Oc2ccccc2-c2ccc(-c3cnc4[nH]ccc4c3)c(F)c2)n1",
        "output": "933"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.CCN(CC)CC.CO.Cc1cc(C)cc(-c2[nH]c3ccc(C(=O)O)cc3c2CCN(CCCCc2ccc(NS(C)(=O)=O)cc2)C(=O)OCc2ccccc2)c1.ClCCl.ClCCl.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>Cc1cc(C)cc(-c2[nH]c3ccc(C(=O)N4CCOCC4)cc3c2CCN(CCCCc2ccc(NS(C)(=O)=O)cc2)C(=O)OCc2ccccc2)c1",
        "output": "44"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)COc1ccc(C)cc1.ClC(Cl)(Cl)Cl.ClCCl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)COc1ccc(CBr)cc1",
        "output": "29"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1cc(OC(F)(F)F)cc(Cl)c1N>>Nc1c(Cl)cc(OC(F)(F)F)cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.Cc1ccccc1.Cc1nc(Cl)c2nc(-c3ccccc3)cc-2[nH]1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].OB(O)c1cccc(C(F)(F)F)c1.[Na+].[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1nc(-c2cccc(C(F)(F)F)c2)c2nc(-c3ccccc3)cc-2[nH]1",
        "output": "875"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCc1nc2c(N)nc3cccnc3c2n1CC1(O)CCNCC1.Cl.Cl.ClCCl.O=C(Cl)N1CCOCC1>>CCc1nc2c(N)nc3cccnc3c2n1CC1(O)CCN(C(=O)N2CCOCC2)CC1",
        "output": "258"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCC2=NCCCN2CC1.CC#N.COC(=O)c1ccn(C)c1S(N)(=O)=O.COc1nc(C)nc(NC(=O)Oc2ccccc2)n1.Cl.O>>COC(=O)c1ccn(C)c1S(=O)(=O)NC(=O)Nc1nc(C)nc(OC)n1",
        "output": "690"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.COc1ccc(C2(C(=O)O)CC2(C)C)cc1.O=S(Cl)Cl>>COc1ccc(C2(C(=O)Cl)CC2(C)C)cc1",
        "output": "53"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.OCc1ccccn1.[Na+]>>COc1cc2nccc(Oc3cc(C)c(NC(=O)OCc4ccccn4)cc3C)c2cc1OC",
        "output": "960"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Nc1cc(F)c(F)c2c1CCCC2=O.CCO.ClC(Cl)Cl.O=C(O)CC(O)(CC(=O)O)C(=O)O.[BH4-].[Na+]>>CC(=O)Nc1cc(F)c(F)c2c1CCCC2",
        "output": "92"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1ncc2c(cc(-c3ccccc3C(F)(F)F)c(=O)n2Cc2ccccc2)c1O.ClCCl.O=C1CCC(=O)N1Br>>COC(=O)c1nc(Br)c2c(cc(-c3ccccc3C(F)(F)F)c(=O)n2Cc2ccccc2)c1O",
        "output": "665"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#CCCOC.O=C(NCCC(O)c1cccc(Br)c1)C(F)(F)F>>COCCC#Cc1cccc(C(O)CCNC(=O)C(F)(F)F)c1",
        "output": "659"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#Cc1cnc2ccccc2c1.CCN(C(C)C)C(C)C.CN(C)C=O.COC(=O)c1cccc(Br)n1.[Cu]I.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1cccc(C#Cc2cnc3ccccc3c2)n1",
        "output": "777"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.O=C(NS(=O)(=O)c1ccc(NCC2CCOCC2)c([N+](=O)[O-])c1)c1ccc(N2CCN(Cc3ccccc3-c3ccc(Cl)cc3)CC2)cc1Oc1ccc2[nH]ccc2c1.[BH3-]C#N.[Na+]>>O=C(NS(=O)(=O)c1ccc(NCC2CCOCC2)c([N+](=O)[O-])c1)c1ccc(N2CCN(Cc3ccccc3-c3ccc(Cl)cc3)CC2)cc1Oc1ccc2c(c1)CCN2",
        "output": "672"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cccc(C)c1NC(=S)NC(=O)c1ccccc1.[Na+].[OH-]>>Cc1cccc(C)c1NC(N)=S",
        "output": "80"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrBr.CCOC(=O)c1ccc(C(C)=O)cc1.CCOCC.O=C([O-])O.[Al+3].[Cl-].[Cl-].[Cl-].[Na+]>>CCOC(=O)c1ccc(C(=O)CBr)cc1",
        "output": "173"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(C)=O.O.O=[N+]([O-])c1cccc2cnccc12.[Cl-].[Fe].[NH4+]>>Nc1cccc2cnccc12",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)OC(C)C.CCOCC.CCOCC.CO.Cl.Clc1ccc(C2(CCOC3CCCCO3)CCNC2)cc1Cl>>OCCC1(c2ccc(Cl)c(Cl)c2)CCNC1",
        "output": "543"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1C(C(=O)O)COC1(C)C.CCN(CC)CC.C[C@@H](O[C@H]1CNC[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.ClCCCl.ClCCl.On1nnc2ccccc21>>C[C@@H](O[C@H]1CN(C(=O)C2COC(C)(C)N2C(=O)OC(C)(C)C)C[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1",
        "output": "685"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CO.COc1cc2ncccc2cc1-c1nnc(N(C)C2CC(C)(C)NC(C)(C)C2)s1.Cl.ClCCl.N.O=C([O-])O.[Na+].c1ccncc1>>CN(c1nnc(-c2cc3cccnc3cc2O)s1)C1CC(C)(C)NC(C)(C)C1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOC(C)=O.O=C(O)CCc1cccc([N+](=O)[O-])c1.[Pd]>>Nc1cccc(CCC(=O)O)c1",
        "output": "1"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1cccc(C(=O)O)c1.O.[Na+].[OH-]>>CC(C)(C)OC(=O)Nc1cccc(C(=O)O)c1",
        "output": "735"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)C1C(=O)CC(CCSc2ccc(C(F)(F)F)cc2)CC1=O.CC(=O)O.O.OO>>CC(=O)C1C(=O)CC(CCS(=O)c2ccc(C(F)(F)F)cc2)CC1=O",
        "output": "199"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C1CCN(C(C)=O)C1c1ccc([N+](=O)[O-])cc1.[Pd]>>CCOC(=O)C1CCN(C(C)=O)C1c1ccc(N)cc1",
        "output": "507"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccccc1N1CCN(c2cc(Cl)c(C(=O)O)cc2[N+](=O)[O-])CC1.F[P-](F)(F)(F)(F)F.NCCCN1CCOC1=O.O>>Cc1ccccc1N1CCN(c2cc(Cl)c(C(=O)NCCCN3CCOC3=O)cc2[N+](=O)[O-])CC1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCN1.CN(C)CC(=O)O.COC(=O)c1cc(Cl)cc2c1NC(c1cccc(Br)c1)C(C)(C)C2.CS(C)=O.Cl.O=C([O-])[O-].[Cu]I.[K+].[K+]>>COC(=O)c1cc(Cl)cc2c1NC(c1cccc(N3CCOCC3)c1)C(C)(C)C2",
        "output": "953"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCCCCC.CCOC(C)=O.CO.CO.NC(=O)c1ccc(F)c2c1CC(NCCCc1c[nH]c3ccc(F)cc13)CO2.O=CC1CC1.[BH3-]C#N.[Na+]>>NC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)CC1CC1)CO2",
        "output": "484"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCN1.N#Cc1cc(F)cc(C(F)(F)F)c1>>N#Cc1cc(N2CCOCC2)cc(C(F)(F)F)c1",
        "output": "26"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCc1nc(N)nc(O)c1C.O=P(Cl)(Cl)Cl>>CCCCc1nc(N)nc(Cl)c1C",
        "output": "168"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CN1CCN(c2cccc3ccc(O)cc23)CC1.ClCCl.O=C(Cl)c1ccccc1.O=C([O-])O.[Na+]>>CN1CCN(c2cccc3ccc(OC(=O)c4ccccc4)cc23)CC1",
        "output": "482"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCC(c2c[nH]c3ccc(N)nc23)CC1.O=C(Cl)C1CCC1>>CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCC4)nc23)CC1",
        "output": "332"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.Cl[Sn]Cl.O=C(N1CCC[C@H](Oc2cc(Cl)ccc2[N+](=O)[O-])C1)C(F)(F)F.O=C([O-])[O-].[K+].[K+]>>Nc1ccc(Cl)cc1O[C@H]1CCCN(C(=O)C(F)(F)F)C1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)C(C)(C)NC(=O)c1ccc2ccccc2c1OC(C)c1nc2ccccc2s1.Cl.[Na+].[OH-]>>CC(Oc1c(C(=O)NC(C)(C)C(=O)O)ccc2ccccc12)c1nc2ccccc2s1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.NCc1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)cc1.O=C=Nc1ccccc1>>O=C(NCc1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)cc1)Nc1ccccc1",
        "output": "814"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)O.CCOC(=O)N1CCC(CCCOc2ccc(C3=NCCCO3)cc2)CC1.[K+].[OH-]>>c1cc(C2=NCCCO2)ccc1OCCCC1CCNCC1",
        "output": "283"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCCO.COc1ccc2ncc(C#N)c(Cl)c2c1.Cl.Nc1ccc2cn[nH]c2c1.c1ccncc1>>COc1ccc2ncc(C#N)c(Nc3ccc4cn[nH]c4c3)c2c1",
        "output": "115"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CNc1ncc(-c2ccnc(S(C)=O)n2)c(CC2CC2)n1.CS(C)=O.NC1CCCCC1>>CNc1ncc(-c2ccnc(NC3CCCCC3)n2)c(CC2CC2)n1",
        "output": "666"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.CN1CCc2ccc(NC(=O)c3cccc(CN)c3)cc2C1.Cl.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(-c2cccc(O)c2)cc1>>CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5cccc(O)c5)cc4)c3)cc2C1",
        "output": "753"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.COc1ccc(C)nc1.Cc1ncccc1O>>COc1cccnc1C",
        "output": "661"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1ccccn1.C#CCCc1nc2c(C)ccc(Cl)c2s1>>Cc1ccc(Cl)c2sc(CCC#Cc3ccccn3)nc12",
        "output": "777"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)c1cc(NC)c([N+](=O)[O-])cc1C(=O)OC.[Pd]>>CCN(CC)c1cc(NC)c(N)cc1C(=O)OC",
        "output": "481"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CCOC(C)=O.ClCCl.N#CCc1ccc(N)cc1>>CC(=O)Nc1ccc(CC#N)cc1",
        "output": "6"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.C=C(C)Cn1cc(-c2cc(C)cc(N)c2)cn1.CC(=O)[O-].CC(=O)[O-].CC(F)c1ccnc(Cl)n1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2]>>C=C(C)Cn1cc(-c2cc(C)cc(Nc3nccc(C(C)F)n3)c2)cn1",
        "output": "808"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.Cc1cc2c(cc1C)CC(C)(NC(=O)c1ccccc1)C2.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>Cc1cc2c(cc1C)CC(C)(NCc1ccccc1)C2",
        "output": "215"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1c(C(=O)OC(C)(C)C)oc2cccc(O)c12.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1I>>Cc1c(C(=O)OC(C)(C)C)oc2ccc(I)c(O)c12",
        "output": "834"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(C)=O.Nc1cc(-c2ccc(CN3CCOCC3)s2)ccc1[N+](=O)[O-].[Pd]>>Nc1ccc(-c2ccc(CN3CCOCC3)s2)cc1N",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.COCCBr.Nc1nc2ccc(O)cc2[n+]([O-])n1.O=C([O-])[O-].[K+].[K+]>>COCCOc1ccc2nc(N)n[n+]([O-])c2c1",
        "output": "75"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C#Cc1cnn2c(C3CC3)cc(-c3ccc(Cl)cc3)nc12.Nc1ccc(Br)cn1>>Nc1ccc(C#Cc2cnn3c(C4CC4)cc(-c4ccc(Cl)cc4)nc23)cn1",
        "output": "719"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)C(CC(C)C)c1cc(-c2ccc(C(F)(F)F)cc2)c(OCC2CC2)c([N+](=O)[O-])c1.CO.O.[Li+].[OH-]>>CC(C)CC(C(=O)O)c1cc(-c2ccc(C(F)(F)F)cc2)c(OCC2CC2)c([N+](=O)[O-])c1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cc[nH]c1C.CN(C)C=O.Fc1ccc(CBr)cc1.O.[H-].[Na+]>>CCOC(=O)c1ccn(Cc2ccc(F)cc2)c1C",
        "output": "528"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccccc1.C.CC(=O)Nc1ccc(C(C)=O)c(O)c1.CN(C)C=O.Cc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+]>>CC(=O)Nc1ccc(C(C)=O)c(OCc2ccccc2)c1",
        "output": "127"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C#Cc1cnn2c(C(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12.NS(=O)(=O)c1cc(Br)c(F)cc1F>>NS(=O)(=O)c1cc(C#Cc2cnn3c(C(F)F)cc(-c4ccc(C(F)(F)F)cc4)nc23)c(F)cc1F",
        "output": "659"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCCCCCCO.CN(C)c1ccncc1.Cc1ccccc1.O=C1CCC(=O)O1>>CCCCCCCCCCCCOC(=O)CCC(=O)O",
        "output": "139"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cl.ClCCN1CCCC1.ClCCl.Nc1ncnc2ccc(-c3cccc(O)c3)nc12.O=C([O-])[O-].[Cs+].[Cs+]>>Nc1ncnc2ccc(-c3cccc(OCCN4CCCC4)c3)nc12",
        "output": "74"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.CCOC(C)=O.O=C1NC(=O)C(=Cc2ccc(OCCc3ccc(OS(=O)(=O)c4ccccc4)cc3)cc2)S1.[Pd]>>O=C1NC(=O)C(Cc2ccc(OCCc3ccc(OS(=O)(=O)c4ccccc4)cc3)cc2)S1",
        "output": "762"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(N(C)C)=[N+]1N=[N+]([O-])c2ncccc21.CN(C)C=O.CN(C)CCN.COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C.F[P-](F)(F)(F)(F)F.O.O=C([O-])O.[Na+]>>COc1cc(C(=O)NCCN(C)C)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCCc1ccc(C(=O)O)cc1.Cc1ccccc1.O=S(Cl)Cl.c1ccncc1>>CCCCCc1ccc(C(=O)Cl)cc1",
        "output": "3"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrBr.Cc1ccccc1C(=O)O.ClCCl.[Fe]>>Cc1ccc(Br)cc1C(=O)O",
        "output": "98"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN=C=NCCCN(C)C.COc1cccc(N2CCNCC2)c1.Cc1onc(-c2cccc(C(F)(F)F)c2)c1C(=O)O.Cl.ClCCl>>COc1cccc(N2CCN(C(=O)c3c(-c4cccc(C(F)(F)F)c4)noc3C)CC2)c1",
        "output": "975"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCOCC(=O)Cl.CNC(=O)Oc1ccc(N)c(C)c1>>CCCOCC(=O)Nc1ccc(OC(=O)NC)cc1C",
        "output": "134"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Fc1cc2ncc(N3CC4CNCC4C3)nc2cc1F.O=C(O)c1cccc(F)c1-n1nccn1>>O=C(c1cccc(F)c1-n1nccn1)N1CC2CN(c3cnc4cc(F)c(F)cc4n3)CC2C1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COCCOC.Cc1cc(CC#N)cc(Cl)c1O.O.[K+].[OH-]>>Cc1cc(CC(=O)O)cc(Cl)c1O",
        "output": "259"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCc1cccc(Nc2ccccc2[N+](=O)[O-])c1.CCO.[Pd]>>CC(C)(C)OC(=O)NCc1cccc(Nc2ccccc2N)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.COc1cc(C=CC(=O)O)ccc1O.Cl.[C].[Pd]>>COc1cc(CCC(=O)O)ccc1O",
        "output": "344"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)O.CC(C)(C)O[Na].COc1cccc2c1CCc1cc(Cl)ccc1C2=O.Cc1ccccc1.Nc1ccccc1N.P.[Pd+2]>>COc1cccc2c1CCc1cc(Nc3ccccc3N)ccc1C2=O",
        "output": "510"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)c1cc(-c2ccccc2)[nH]n1.CO.O.O.[Li]O>>O=C(O)c1cc(-c2ccccc2)[nH]n1",
        "output": "171"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CCN.CCO.O=[N+]([O-])c1ccc(Cl)c([N+](=O)[O-])c1.[NH4+].[OH-]>>CCN(CC)CCNc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]",
        "output": "304"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CCN=C=NCCCN(C)C.COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCNCC4)cc3)nc2c1.O=C(O)CC(F)(F)F.On1nnc2ccccc21>>COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCN(C(=O)CC(F)(F)F)CC4)cc3)nc2c1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)Cn1cc(-c2ccc(N3CCC(N4CCc5ccc(F)cc54)CC3)nn2)cn1.CN.CO.O>>CNC(=O)Cn1cc(-c2ccc(N3CCC(N4CCc5ccc(F)cc54)CC3)nn2)cn1",
        "output": "64"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)N1CCC(C(=O)O)CC1.Cc1ccc(C(=O)N(C)[C@@H]2CCNC[C@H]2c2ccc(Cl)c(Cl)c2)cc1>>CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.Cc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1O.[H][H].[Ni]>>Cc1cc(N)cc(N)c1O",
        "output": "204"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC[N+](CC)(CC)Cc1ccccc1.ClC(Cl)Cl.Clc1cc(CBr)ccc1Br.O.[C-]#N.[Cl-].[Na+]>>N#CCc1ccc(Br)c(Cl)c1",
        "output": "39"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCc2ccc(F)cc21.ClCCl.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1CCc2cc(Br)c(F)cc21",
        "output": "4"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)S(=O)(=O)c1cccc([N+](=O)[O-])c1NCCO.CO.O.O=S([O-])S(=O)[O-].[Na+].[Na+]>>CN(C)S(=O)(=O)c1cccc(N)c1NCCO",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COc1cc(C(F)(F)F)cc(SC)c1C(=O)NC1CCCC1NC(=O)OC(C)(C)C.Cl.O=C([O-])[O-].[Na+].[Na+]>>COc1cc(C(F)(F)F)cc(SC)c1C(=O)NC1CCCC1N",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#C[C@@](C)(O)c1cc(C)on1.CS(C)=O.Cc1nc2ccccc2n1Cc1c(C(N)=O)nc2n1CCOc1ccc(Br)cc1-2.NC(=O)c1nc2n(c1COc1ccccc1Cl)CCOc1ccc(Br)cc1-2.Oc1ccccc1Cl.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(COc4ccccc4Cl)n2CCO3)no1",
        "output": "659"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.Cc1ccc(C)c(CN2CCN(C)CC(N)C2)c1.O=C(O)c1n[nH]c2ccccc12>>Cc1ccc(C)c(CN2CCN(C)CC(NC(=O)c3n[nH]c4ccccc34)C2)c1",
        "output": "816"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CNC1.Cc1sc2cc(OCCCCBr)ccc2c1-c1ccc(Br)cc1>>Cc1sc2cc(OCCCCN3CCC3)ccc2c1-c1ccc(Br)cc1",
        "output": "73"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCCOc1ccc(OC(C)(C)C(=O)OCC)c(C)c1.Clc1ccc(I)cc1>>CCOC(=O)C(C)(C)Oc1ccc(OCCC#Cc2ccc(Cl)cc2)cc1C",
        "output": "664"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COc1ccc(-c2n[nH]c3c2Cc2sc(-c4ccc(N)nc4)cc2-3)cc1.C[Si](C)(C)CCOCCl.[H-].[Na+]>>COc1ccc(-c2nn(COCC[Si](C)(C)C)c3c2Cc2sc(-c4ccc(N)nc4)cc2-3)cc1",
        "output": "910"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.OCC1CN(Cc2ccccc2)CCN1Cc1ccccc1>>CC(C)(C)[Si](C)(C)OCC1CN(Cc2ccccc2)CCN1Cc1ccccc1",
        "output": "193"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrBr.ClC(Cl)(Cl)Cl.O=S([O-])([O-])=S.[Na+].[Na+].c1cncc(-c2c3ccccc3cc3ccccc23)c1>>Brc1c2ccccc2c(-c2cccnc2)c2ccccc12",
        "output": "98"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.Cc1sc2cc(OCCOS(C)(=O)=O)ccc2c1-c1ccc(C(F)(F)F)cc1.[N-]=[N+]=[N-].[Na+]>>Cc1sc2cc(OCCN=[N+]=[N-])ccc2c1-c1ccc(C(F)(F)F)cc1",
        "output": "322"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.CCCC1CCC(c2ccc(B(O)O)cc2)CC1.O.O=C([O-])[O-].Oc1ccc(Br)cc1F.[K+].[K+]>>CCCC1CCC(c2ccc(-c3ccc(O)c(F)c3)cc2)CC1",
        "output": "837"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Brc1cncc(Nc2ccccc2)c1.CC(=O)Nc1cccc(B(O)O)c1.CC(=O)[O-].CC(=O)[O-].CN(C)C=O.O.O=C([O-])O.[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(=O)Nc1cccc(-c2cncc(Nc3ccccc3)c2)c1",
        "output": "833"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCNc2ccccc21.O=C1CCC(=O)N1Br>>CC(C)(C)OC(=O)N1CCNc2ccc(Br)cc21",
        "output": "4"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)[C@H](C)N)c1.O=C(Cl)CF>>COc1cccc([C@@H](Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)[C@H](C)NC(=O)CF)c1",
        "output": "45"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.ClCc1ccc2ccccc2n1.O.O=C([O-])[O-].O=Cc1ccc(O)cc1.[K+].[K+]>>O=Cc1ccc(OCc2ccc3ccccc3n2)cc1",
        "output": "616"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccccc1.ClCCl.O=C(Cc1cccs1)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(COc3cc(Cl)ccc3Oc3ccc(Cl)cc3Cl)CS[C@H]12>>O=C(Cc1cccs1)NC1C(=O)N2C(C(=O)O)=C(COc3cc(Cl)ccc3Oc3ccc(Cl)cc3Cl)CS[C@H]12",
        "output": "228"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.COC(=O)c1cccc(=O)n1CC(=O)c1ccc(Cl)cc1.Cl.O.[Na+].[OH-]>>O=C(Cn1c(C(=O)O)cccc1=O)c1ccc(Cl)cc1",
        "output": "152"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.CCOC(C)=O.COC(=O)Cn1ccc2cc(OCc3ccccc3)ccc21.[Pd]>>COC(=O)Cn1ccc2cc(O)ccc21",
        "output": "23"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.Cc1nc2ccc(C#CC(C)(C)CO[Si](C)(C)C(C)(C)C)cc2n1-c1ncnc(N)n1.[F-]>>Cc1nc2ccc(C#CC(C)(C)CO)cc2n1-c1ncnc(N)n1",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CO)C(=O)O.CN(C)C=O.Cl.O.O=[N+]([O-])c1cccc(C(F)(F)F)c1F.[H-].[Na+]>>CC(C)(C)OC(=O)N[C@@H](COc1c([N+](=O)[O-])cccc1C(F)(F)F)C(=O)O",
        "output": "485"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)COCCOCCOCCOCCO.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)COCCOCCOCCOCCOS(C)(=O)=O",
        "output": "0"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COC(=O)c1ccc(C(=O)O)c([N+](=O)[O-])c1.[C].[Pd]>>COC(=O)c1ccc(C(=O)O)c(N)c1",
        "output": "481"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)CC(C)Nc1ccc(C(=O)N[C@@H](CC(C)C)C(=O)OC(C)(C)C)cc1[N+](=O)[O-].CCO.[Pd]>>CC(C)CC(C)Nc1ccc(C(=O)N[C@@H](CC(C)C)C(=O)OC(C)(C)C)cc1N",
        "output": "489"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.COC(=O)CNCc1cnc2[nH]c(-c3cc(OCc4ccccc4)ccc3OC(C)C)nc2c1.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>CC(C)Oc1ccc(OCc2ccccc2)cc1-c1nc2cc(CNCC(=O)O)cnc2[nH]1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "N[C@@H]1[C@@H](C(=O)O)O[C@@H](n2cnc3c(NC(=O)c4ccccc4)ncnc32)[C@@H]1O.O=C(O)CCNC(=O)OCc1ccccc1>>O=C(CCNC(=O)OCc1ccccc1)N[C@@H]1[C@@H](C(=O)O)O[C@@H](n2cnc3c(NC(=O)c4ccccc4)ncnc32)[C@@H]1O",
        "output": "230"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CN1CCCC1=O.Cc1c(-c2ccccn2)nc2ccccc2c1Cl.Cl.Nc1cc(N2CCOCC2)cnc1N1CCOCC1>>Cc1c(-c2ccccn2)nc2ccccc2c1Nc1cc(N2CCOCC2)cnc1N1CCOCC1",
        "output": "859"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)C[C@@H]1COc2cc(NCc3cccc(-n4c(C)nc5ccccc54)c3F)ccc21.[Na+].[OH-]>>Cc1nc2ccccc2n1-c1cccc(CNc2ccc3c(c2)OC[C@H]3CC(=O)O)c1F",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCNCC.ClCCl.O=C(O)c1cc(Br)cc(F)c1Oc1ccc(Cl)nc1>>CCN(CC)C(=O)c1cc(Br)cc(F)c1Oc1ccc(Cl)nc1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccc(N(CC(=O)O)S(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1.OCCNCc1ccccc1>>Cc1ccc(N(CC(=O)N(CCO)Cc2ccccc2)S(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1",
        "output": "633"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN1C(=O)CC(C)(C)c2cc(C)c(-c3cc(C4CC4C(=O)OC(C)(C)C)ccc3OC(F)(F)F)cc21.ClCCl.O=C(O)C(F)(F)F>>CCN1C(=O)CC(C)(C)c2cc(C)c(-c3cc(C4CC4C(=O)O)ccc3OC(F)(F)F)cc21",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.CCOC(C)=O.Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)O.F[P-](F)(F)(F)(F)F.OC1(Cc2ccc(F)cc2)CCNCC1.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCC(O)(Cc2ccc(F)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.C[C@@](O)(C(=O)Nc1ccc(S)cc1Cl)C(F)(F)F.C[O-].O.O=[N+]([O-])c1ccccc1I.[Na+]>>C[C@@](O)(C(=O)Nc1ccc(Sc2ccccc2[N+](=O)[O-])cc1Cl)C(F)(F)F",
        "output": "565"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)NCC1CCNCC1.CC(C)(C)OC(=O)N[C@H]1CCNC1.O=S(=O)(Cl)c1cccc2cncc(Br)c12.O=S(=O)(Cl)c1cccc2cncc(Cl)c12>>CC(C)(C)OC(=O)NCC1CCN(S(=O)(=O)c2cccc3cncc(Cl)c23)CC1",
        "output": "99"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)c1ccc(-c2ccc(C(=O)OC(C)(C)C)c(NC(=O)c3ccccc3)c2)cc1.O=C(O)C(F)(F)F>>CN(C)c1ccc(-c2ccc(C(=O)O)c(NC(=O)c3ccccc3)c2)cc1",
        "output": "752"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCOC(C)=O.Cc1nc2c([N+](=O)[O-])ccc(C#N)c2o1.[Fe]>>Cc1nc2c(N)ccc(C#N)c2o1",
        "output": "269"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)O[C@H]1CCNC1=O.FC(F)c1ccc(CBr)cc1.[H-].[Na+]>>CC(C)(C)[Si](C)(C)O[C@H]1CCN(Cc2ccc(C(F)F)cc2)C1=O",
        "output": "774"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.Cl.Nc1ccccc1.O.O=C(Cl)c1ccccc1>>O=C(Nc1ccccc1)c1ccccc1",
        "output": "11"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOc1cc(-c2cnc[nH]c2=O)ccc1N.Cc1ccccc1N=C=O.ClCCl>>CCOc1cc(-c2cnc[nH]c2=O)ccc1NC(=O)Nc1ccccc1C",
        "output": "473"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(C)C[C@@H](O)[C@H](NC(=O)OCC[Si](C)(C)C)CO1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>>CC1(C)C[C@@H](OS(C)(=O)=O)[C@H](NC(=O)OCC[Si](C)(C)C)CO1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCc2[nH]c(C3CNCCO3)nc2C1.CCN(C(C)C)C(C)C.CCO.Nc1nc(Cl)cc(Cl)n1>>Nc1nc(Cl)cc(N2CCOC(c3nc4c([nH]3)CCCC4)C2)n1",
        "output": "162"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN1CCCC1=O.CSc1ccc(CN)cc1.Cc1ccc(C(=O)O)c(=O)n1-c1cccc(C(F)(F)F)c1.F[P-](F)(F)(F)(F)F>>CSc1ccc(CNC(=O)c2ccc(C)n(-c3cccc(C(F)(F)F)c3)c2=O)cc1",
        "output": "790"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CCCO1.O=[N+]([O-])c1ccc(N2C3CCC2CC3)cc1C(F)(F)F.[H][H].[Pd]>>Nc1ccc(N2C3CCC2CC3)cc1C(F)(F)F",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)C(C)(C)Oc1ccc([N+](=O)[O-])c(F)c1.CCOC(C)=O.[H][H].[Pd]>>CCOC(=O)C(C)(C)Oc1ccc(N)c(F)c1",
        "output": "202"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)C[C@H](N)C(N)=O.O=C(O)c1cccc(C(O)c2ccc(F)cc2)n1>>CC(C)C[C@H](NC(=O)c1cccc(C(O)c2ccc(F)cc2)n1)C(N)=O",
        "output": "738"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CCCCc1nc(C(O)(C(C)C)C(C)C)c(C(N)=O)n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.Cl>>CCCCc1nc(C(O)(C(C)C)C(C)C)c(C(N)=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CN(CCc1ccc(C(N)=O)cc1)C(C)(C)COC(c1ccccc1)c1ccccc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CN(CCc1ccc(CN)cc1)C(C)(C)COC(c1ccccc1)c1ccccc1",
        "output": "215"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)c1noc(N2CCC(n3ccc4cc(Br)c(F)cc43)CC2)n1.CC1(C)OB(c2ccc(S(C)(=O)=O)cc2)OC1(C)C>>CC(C)c1noc(N2CCC(n3ccc4cc(-c5ccc(S(C)(=O)=O)cc5)c(F)cc43)CC2)n1",
        "output": "933"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc2c(-c3ccc(F)cc3)cn(C)c2c1.O.O.[Li]O>>Cn1cc(-c2ccc(F)cc2)c2ccc(C(=O)O)cc21",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)C[AlH]CC(C)C.COc1ccc(Nc2nc(Nc3cc(OC)c(OC)c(OC)c3)ncc2Cl)c(N(CC#N)S(C)(=O)=O)c1.Cc1ccccc1.Cl.ClCCl.[Cl-].[NH4+]>>COc1ccc(Nc2nc(Nc3cc(OC)c(OC)c(OC)c3)ncc2Cl)c(N(CCN)S(C)(=O)=O)c1",
        "output": "246"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COC(CN2CCNCC2)C1.N#CCBr>>N#CCN1CCN(CC2CCCO2)CC1",
        "output": "880"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCS(=O)(=O)Cl.ClCCl.Nc1ncc(N2CCNCC2)nc1-c1nc2ccccc2[nH]1>>CCS(=O)(=O)N1CCN(c2cnc(N)c(-c3nc4ccccc4[nH]3)n2)CC1",
        "output": "584"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC[NH+](CC)CC.O=P(Cl)(Cl)Cl.O=c1ccc2c(OCCN3CCCCC3)ccc(Cl)c2[nH]1.[Cl-]>>Clc1ccc2c(OCCN3CCCCC3)ccc(Cl)c2n1",
        "output": "100"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N(C)C.CCOC(C)=O.CI.Cl.O.O=C([O-])[O-].O=c1[nH]ccc(Cl)c1[N+](=O)[O-].[K+].[K+]>>Cn1ccc(Cl)c([N+](=O)[O-])c1=O",
        "output": "191"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.Cl.Cn1c(=O)n(CCCO[Si](C)(C)C(C)(C)C)c(=O)c2c1nc(OC1CCCC1)n2Cc1ccc(Cl)cc1.O>>Cn1c(=O)n(CCCO)c(=O)c2c1nc(OC1CCCC1)n2Cc1ccc(Cl)cc1",
        "output": "708"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrB(Br)Br.COc1ccc(-c2c(C)ncnc2C)c2cnccc12.ClCCl>>Cc1ncnc(C)c1-c1ccc(O)c2ccncc12",
        "output": "48"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)Nc1cnccc1C1(F)COC1.ClCCl.O=C(O)C(F)(F)F>>Nc1cnccc1C1(F)COC1",
        "output": "877"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1ccccc1.O=C(O)c1n[nH]c2cc(Cl)c(Br)cc12.O=C([O-])[O-].OCc1ccc(B(O)O)cc1.[K+].[K+]>>O=C(O)c1n[nH]c2cc(Cl)c(-c3ccc(CO)cc3)cc12",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)n1ncnc1-c1cn2c(n1)-c1cc(SC3CCN(C(=O)OC(C)(C)C)CC3)ccc1OCC2.ClCCl.O=C(O)C(F)(F)F>>CC(C)n1ncnc1-c1cn2c(n1)-c1cc(SC3CCNCC3)ccc1OCC2",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)c1ccnc(-c2cc(F)c(OCc3ccccc3)c(C#N)c2)c1.[C].[Pd]>>COC(=O)c1ccnc(-c2cc(F)c(O)c(C#N)c2)c1",
        "output": "23"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCOc1ccccc1-c1ncc(-c2nnn[nH]2)c(=O)[nH]1.O=S(=O)(O)O.O=[N+]([O-])O>>CCCOc1ccc([N+](=O)[O-])cc1-c1ncc(-c2nnn[nH]2)c(=O)[nH]1",
        "output": "21"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CN(C)CCN.Cc1cnc(-c2ccccc2NC(=O)c2cc(Cl)nc(-c3ccccc3)n2)o1.O>>Cc1cnc(-c2ccccc2NC(=O)c2cc(NCCN(C)C)nc(-c3ccccc3)n2)o1",
        "output": "166"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1ccc2[nH]cnc2c1.S=C=Nc1ccc(I)cc1>>S=C(Nc1ccc(I)cc1)Nc1ccc2[nH]cnc2c1",
        "output": "474"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(-c2nn(C3CCCC3)c3cc[nH]c(=O)c23)cs1.Cl.[Na+].[OH-]>>O=C(O)c1cc(-c2nn(C3CCCC3)c3cc[nH]c(=O)c23)cs1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)C[C@@H]1CC=CCCC(=O)N[C@H](Cc2ccccc2)COC1=O.CO.ClCCl.ClCCl.NCc1ccc(Cl)cc1.O=C(O)C(F)(F)F.O=C(O)C[C@@H]1CC=CCCC(=O)N[C@H](Cc2ccccc2)COC1=O>>O=C(C[C@@H]1CC=CCCC(=O)N[C@H](Cc2ccccc2)COC1=O)NCc1ccc(Cl)cc1",
        "output": "599"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCCCCCCCCCCBr.CN(C)C=O.Cl.O.O=C([O-])[O-].Oc1ccc(I)cc1.[K+].[K+]>>CCCCCCCCCCCCOc1ccc(I)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Nc1c([N+](=O)[O-])ccc(Cl)c1Cl.[H][H].[Ni]>>Nc1ccc(Cl)c(Cl)c1N",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.CCCCCCCCc1ccc(OCC(O)Cn2ncc3ccccc32)cc1.CS(C)=O.O=C([O-])O.[Cl-].[Na+].[Na+]>>CCCCCCCCc1ccc(OCC(=O)Cn2ncc3ccccc32)cc1",
        "output": "87"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCO.Cl.Clc1ncccn1.O=C(c1ccc(F)cc1)C1CCNCC1>>O=C(c1ccc(F)cc1)C1CCN(c2ncccn2)CC1",
        "output": "36"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(=O)c1nccn2c(-c3ccc(F)cc3)ncc12.CO.O.[K+].[OH-]>>O=C(O)c1nccn2c(-c3ccc(F)cc3)ncc12",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)Cl.N#Cc1ccc(N)cn1.c1ccncc1>>CS(=O)(=O)Nc1ccc(C#N)nc1",
        "output": "812"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C(CC#N)CN4CCC(=O)CC4)c3)ncnc21.[BH4-].[Na+]>>C[Si](C)(C)CCOCn1ccc2c(-c3cnn(C(CC#N)CN4CCC(O)CC4)c3)ncnc21",
        "output": "91"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)c1ccc(Cl)nc1NCC1CC1.CN(C)C=O.OCC(F)(F)F.[H-].[Na+]>>CCOC(=O)c1ccc(OCC(F)(F)F)nc1NCC1CC1",
        "output": "433"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1C[C@@H](CCl)c2c1cc(O)c1ccccc21.CCOC(C)=O.CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(CBr)cc1.[K+].[K+]>>CC(C)(C)OC(=O)N1C[C@@H](CCl)c2c1cc(OCc1ccc([N+](=O)[O-])cc1)c1ccccc21",
        "output": "127"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrBr.CC(=O)c1cc2cc(C#N)ccc2o1.ClC(Cl)Cl.ClCCl>>N#Cc1ccc2oc(C(=O)CBr)cc2c1",
        "output": "173"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(C)OC(=O)Cl.CC(C)OC(=O)N1CCC(Oc2cc(N3CCc4cc(C(=O)O)ccc43)ncn2)CC1.CCN(CC)CC.O.[BH4-].[Na+]>>CC(C)OC(=O)N1CCC(Oc2cc(N3CCc4cc(CO)ccc43)ncn2)CC1",
        "output": "72"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.Cl.Cl.ClCCl.NC(c1ccccc1)c1cc2ccncc2[nH]1.O=C(O)c1cccnc1>>O=C(NC(c1ccccc1)c1cc2ccncc2[nH]1)c1cccnc1",
        "output": "790"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl.O=C(NCCCO)c1ccc[nH]1>>O=CCCNC(=O)c1ccc[nH]1",
        "output": "142"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cc1ccc(C(=O)O)cc1NC(=O)c1csc2c(NC3CC3)ncnc12.Cc1cn(-c2cc(N)cc(C(F)(F)F)c2)cn1>>Cc1cn(-c2cc(NC(=O)c3ccc(C)c(NC(=O)c4csc5c(NC6CC6)ncnc45)c3)cc(C(F)(F)F)c2)cn1",
        "output": "50"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1ncc(Br)cc1NS(C)(=O)=O.Cc1ccccc1.[K+]>>COc1ncc(B2OC(C)(C)C(C)(C)O2)cc1NS(C)(=O)=O",
        "output": "943"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.N#CCBr.O=C([O-])[O-].Oc1cccc2c1c1cccc3c1n2[C@@H](c1ccccc1)CO3.[K+].[K+]>>N#CCOc1cccc2c1c1cccc3c1n2[C@@H](c1ccccc1)CO3",
        "output": "802"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)/C=C/c1ccc2ccccc2c1.Cl.O.O.[Li+].[OH-]>>O=C(O)/C=C/c1ccc2ccccc2c1",
        "output": "122"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)=O.C[C@H]1OC(O)[C@H](O)C[C@H]1O.Fc1cccc(CBr)c1.N#Cc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>N#Cc1ccc(OCc2cccc(F)c2)cc1",
        "output": "127"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.Cc1cc2ncc(-c3ccc(C#N)cc3)n2cc1-c1ccc(C(=O)[O-])cc1.O.[Li+].[OH-]>>Cc1cc2ncc(-c3ccc(C#N)cc3)n2cc1-c1ccc(C(=O)O)cc1",
        "output": "151"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(N2CCc3cc(-c4ccc(Cl)cc4)sc3C2=O)cc1OC.[Na+].[OH-]>>COc1cc(N2CCc3cc(-c4ccc(Cl)cc4)sc3C2=O)ccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)N.COc1ccc(I)c(Sc2nc3c(N)ncnc3n2CCCOS(C)(=O)=O)c1>>COc1ccc(I)c(Sc2nc3c(N)ncnc3n2CCCNC(C)(C)C)c1",
        "output": "559"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)COC1CCN(C(=O)OCc2ccccc2)CC1.[C].[Pd]>>COC(=O)COC1CCNCC1",
        "output": "428"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)c1ccc2c(c1)OC1(O)c3cccc([N+](=O)[O-])c3C(=O)C21NC(=O)c1ccc(Cl)cc1.CCO.O.[Fe]>>CC(C)c1ccc2c(c1)OC1(O)c3cccc(N)c3C(=O)C21NC(=O)c1ccc(Cl)cc1",
        "output": "706"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1nc(-c2ccc(Cl)cc2Cl)n(-c2ccc(OCCC(F)(F)F)cc2)c1C.O.[K+].[OH-]>>Cc1c(C(=O)O)nc(-c2ccc(Cl)cc2Cl)n1-c1ccc(OCCC(F)(F)F)cc1",
        "output": "171"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)=O.NCc1ccccn1.O=C(Cl)CCl.O=C([O-])[O-].[K+].[K+]>>O=C(CCl)NCc1ccccn1",
        "output": "45"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCI.N#Cc1ccc(-c2ccc(N3CC[C@@H]4CNC[C@@H]43)cc2)cc1.O.[H-].[Na+]>>CCN1C[C@H]2CCN(c3ccc(-c4ccc(C#N)cc4)cc3)[C@H]2C1",
        "output": "184"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCCCCCc1ccccc1.Cl.ClCCl.N#Cc1cccc(CC(=O)O)c1.[Al+3].[Cl-].[Cl-].[Cl-]>>CCCCCCCCc1ccc(C(=O)Cc2cccc(C#N)c2)cc1",
        "output": "435"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)CN1CCOCC1.Cl.[Na+].[OH-]>>O=C(O)CN1CCOCC1",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.COC(=O)c1ccc2c(c1)S(=O)(=O)N=C(c1c(O)c3ccccc3n(CCC(C)C)c1=O)N2.Cl.[Na+].[OH-]>>CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3cc(C(=O)O)ccc3N2)c(O)c2ccccc21",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCN([C@@H]2CCNC2)CC1.CN(C)C=O.Cl.Cl.Clc1nc2cc(Br)ccc2s1.O.O=C([O-])[O-].[K+].[K+]>>Brc1ccc2sc(N3CC[C@@H](N4CCCCC4)C3)nc2c1",
        "output": "558"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCCCC(C=CC(CCCC)C(=O)OCC)C(=O)OCC.Cl.[Na+].[OH-]>>CCCCC(C=CC(CCCC)C(=O)O)C(=O)O",
        "output": "255"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O.O=[N+]([O-])c1cc(Br)cc(CBr)c1.[C-]#N.[K+]>>N#CCc1cc(Br)cc([N+](=O)[O-])c1",
        "output": "39"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(=O)Cl.CCN(C(C)C)C(C)C.COc1ccc(N2CCOCC2)c2sc(-c3nc4c([nH]3)CCNCC4)nc12.Cl>>COc1ccc(N2CCOCC2)c2sc(-c3nc4c([nH]3)CCN(C(C)=O)CC4)nc12",
        "output": "125"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1CCNc2ccccc21.ClCCl.O=C1CCC(=O)N1Br>>CC1CCNc2ccc(Br)cc21",
        "output": "4"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "ClCC1CO1.Oc1cccc2c1CCC=C2.[Na+].[OH-]>>C1=Cc2cccc(OCC3CO3)c2CC1",
        "output": "15"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1c2n(c3c(Br)cc(Cl)cc13)CCNC2=O.OB(O)c1ccc(Cl)nc1>>Cc1c2n(c3c(-c4ccc(Cl)nc4)cc(Cl)cc13)CCNC2=O",
        "output": "883"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc(CC(=O)O)cc(OC)c1OC.O=S(Cl)Cl>>COc1cc(CC(=O)Cl)cc(OC)c1OC",
        "output": "53"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CO.COC(=O)[C@@H]1CC[C@H](C(=O)N2CC[C@@]3(C)c4cccc(O)c4C[C@@H]2C3(C)C)CC1.Cl.[Na+].[OH-]>>CC1(C)[C@H]2Cc3c(O)cccc3[C@]1(C)CCN2C(=O)[C@H]1CC[C@@H](C(=O)O)CC1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.O=C(O)CCc1cccc(F)c1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCc1cccc(F)c1",
        "output": "231"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NC1CCN(S(=O)(=O)c2ccc(C(=O)O)c(F)c2)CC1.ClCCl.NCCc1ccccc1.O=S(Cl)Cl.c1ccncc1>>CC(C)(C)OC(=O)NC1CCN(S(=O)(=O)c2ccc(C(=O)NCCc3ccccc3)c(F)c2)CC1",
        "output": "835"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(N)c1nc2ccccc2[nH]1.CCN(C(C)C)C(C)C.CCO.CN(C)C(On1nnc2ccccc21)=[N+](C)C.Cc1cc(C(=O)O)ccc1C(=O)N1CCCC1.ClCCl.F[B-](F)(F)F>>Cc1cc(C(=O)NC(C)c2nc3ccccc3[nH]2)ccc1C(=O)N1CCCC1",
        "output": "902"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CS(=O)(=O)OCC1CCOC1.Oc1ccc(-c2ccc(Cn3cc4nc(-c5cccc(F)c5F)nc-4cn3)nn2)c(C(F)(F)F)c1>>Fc1cccc(-c2nc3cnn(Cc4ccc(-c5ccc(OCC6CCOC6)cc5C(F)(F)F)nn4)cc-3n2)c1F",
        "output": "702"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(N)Cc1cccc([N+](=O)[O-])c1.COC(=O)Cl.O=C([O-])[O-].[K+].[K+]>>COC(=O)NC(C)Cc1cccc([N+](=O)[O-])c1",
        "output": "94"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC.O=C(O)Cc1ccc2c(c1)OCO2.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCc1ccc2c(c1)OCO2",
        "output": "231"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cccc2c1cc(CO)n2Cc1ccccc1.ClCCl.[Mn+4].[O-2].[O-2]>>COc1cccc2c1cc(C=O)n2Cc1ccccc1",
        "output": "263"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCOCCOCCOCCOCCN1.O=C(Cl)C12CC3CC(CC(C3)C1)C2>>O=C(N1CCOCCOCCOCCOCCOCC1)C12CC3CC(CC(C3)C1)C2",
        "output": "125"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CC(=O)O.Nc1ncccc1C(F)(F)F.O>>Nc1ncc(Br)cc1C(F)(F)F",
        "output": "292"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCCCCCCCCCCCOc1ccc(C(=O)Cl)cc1.ClC(Cl)Cl.ClCCl.Nc1ccccc1.O.c1ccncc1>>CCCCCCCCCCCCCCOc1ccc(C(=O)Nc2ccccc2)cc1",
        "output": "11"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)N[C@@H](C)c1ccc(C2CCN(c3ccc(O)cc3)CC2)cc1.CC(C)OC(=O)N=NC(=O)OC(C)C.CC1CC1CO.CC1CCCO1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(=O)N[C@@H](C)c1ccc(C2CCN(c3ccc(OCC4CC4C)cc3)CC2)cc1",
        "output": "478"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.Cl.ClCc1cccnc1.O=c1cc(-c2ccc(O)cc2)oc(N2CCOCC2)c1.[H-].[Na+]>>O=c1cc(-c2ccc(OCc3cccnc3)cc2)oc(N2CCOCC2)c1",
        "output": "678"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)c1ccc(N=C=O)cc1.COc1ccc(N)cc1-c1c(Cl)cnn1C>>COc1ccc(NC(=O)Nc2ccc(C(C)C)cc2)cc1-c1c(Cl)cnn1C",
        "output": "804"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)NCCC[C@H]1OC[C@@H](Oc2ccc(OCc3ccccc3)cc2)CO1.CCO.[Pd]>>CC(=O)NCCC[C@H]1OC[C@@H](Oc2ccc(O)cc2)CO1",
        "output": "23"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CN.Cc1cc(Cl)nc(Cl)c1[N+](=O)[O-].O>>CNc1nc(Cl)cc(C)c1[N+](=O)[O-]",
        "output": "70"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)C1(c2ccc(Cl)cc2)CCNCC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl>>CC(=O)C1(c2ccc(Cl)cc2)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "694"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.CCOCC.CCn1cc(C(=O)O)c(=O)c2c(F)c(F)c(F)c(F)c21.CN1CCCC1=O>>CCn1cc(C(=O)O)c(=O)c2c(F)c(F)c(N3CCOCC3)c(F)c21",
        "output": "676"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1c(C(C)n2nc(Br)c3c(N)ncnc32)cc(Cl)c(C)c1C1CN(C(=O)OC(C)(C)C)C1.ClCCl.O=C(O)C(F)(F)F.[Na+].[OH-]>>COc1c(C(C)n2nc(Br)c3c(N)ncnc32)cc(Cl)c(C)c1C1CNC1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.COC(=O)Cc1ccc(OC)c(O)c1.COCCCBr.O=C([O-])[O-].[K+].[K+]>>COCCCOc1cc(CC(=O)OC)ccc1OC",
        "output": "75"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.CCN(CC)CC.COc1ccc2[nH]cc(CCN)c2c1>>COc1ccc2[nH]cc(CCNC(C)=O)c2c1",
        "output": "339"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCc1nc(CO)c(Cl)n1Cc1ccc(OCCC2CCCCC2C(=O)OC)cc1.CCO.[Na+].[OH-]>>CCCCc1nc(CO)c(Cl)n1Cc1ccc(OCCC2CCCCC2C(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O=C(O)C(=O)O.OC1CCC(N(Cc2ccccc2)Cc2ccccc2)CC1>>O=C1CCC(N(Cc2ccccc2)Cc2ccccc2)CC1",
        "output": "87"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cccc(CO)n1.O=S(=O)(Nc1ncc(Cl)nc1Cl)c1cccc(Cl)c1Cl>>Cc1cccc(COc2nc(Cl)cnc2NS(=O)(=O)c2cccc(Cl)c2Cl)n1",
        "output": "209"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.C[Si](C)(C)C#Cc1ccc(N)c([N+](=O)[O-])c1.ClCCl.O.O=C([O-])[O-].[K+].[K+]>>C#Cc1ccc(N)c([N+](=O)[O-])c1",
        "output": "337"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(B2OC(C)(C)C(C)(C)O2)cc(C)c1Br.Cc1cncc(Br)n1>>Cc1cncc(-c2cc(C)c(Br)c(C)c2)n1",
        "output": "937"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.O=C(O)c1ccc(O)c2[nH]c(-c3ccc(Cl)cc3Cl)nc12.O=S(=O)(O)O>>COC(=O)c1ccc(O)c2[nH]c(-c3ccc(Cl)cc3Cl)nc12",
        "output": "521"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)c1ccc(N)c(Sc2ccc(F)cc2F)c1.CS(=O)(=O)Cl.Cl.c1ccncc1>>CC(=O)c1ccc(NS(C)(=O)=O)c(Sc2ccc(F)cc2F)c1",
        "output": "194"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O.CCN(C(C)C)C(C)C.CCOCC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1.O>>CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CN(c1ccnc(-c2ccccc2)n1)c1nc(Cl)ncc1F.Cc1ccc(S(=O)(=O)O)cc1.NCCc1cccnc1>>CN(c1ccnc(-c2ccccc2)n1)c1nc(NCCc2cccnc2)ncc1F",
        "output": "544"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCCCCC1(CCCCCCBr)c2ccccc2-c2ccc(Br)cc21.C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CC1(C)OB(c2ccc3c(c2)C(CCCCCCBr)(CCCCCCBr)c2ccccc2-3)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)(C)[O-].CC1CCCN1CCCO.CCOC(C)=O.Clc1ccc(C2=NC3(CCCCC3)CO2)cn1.[K+]>>CC1CCCN1CCCOc1ccc(C2=NC3(CCCCC3)CO2)cn1",
        "output": "433"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCNC1.CCN1CCC(=O)CC1.CO.O.O=[N+]([O-])c1ccc2[nH]ccc2c1>>CCN1CC=C(c2c[nH]c3ccc([N+](=O)[O-])cc23)CC1",
        "output": "607"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.CC(C)(C)OC(=O)N1CCN(C(CN)c2ccccc2Cl)CC1.CCOC(C)=O.c1ccncc1>>CC(=O)NCC(c1ccccc1Cl)N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "339"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)O.CCCO.ClCCCCCl.O=C([O-])[O-].O=C1CCc2ccc(O)cc2N1.[K+].[K+]>>O=C1CCc2ccc(OCCCCCl)cc2N1",
        "output": "74"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CO.COCC(=O)Nc1cc(Oc2ccc([N+](=O)[O-])cc2C)ccn1.[H][H].[Pt]>>COCC(=O)Nc1cc(Oc2ccc(N)cc2C)ccn1",
        "output": "335"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Cl[Sn]Cl.O=[N+]([O-])c1ccc2c(c1)C(=CCCN1CCC(O)(c3ccc(Cl)cc3)CC1)c1ccccc1CO2>>Nc1ccc2c(c1)C(=CCCN1CCC(O)(c3ccc(Cl)cc3)CC1)c1ccccc1CO2",
        "output": "202"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCNCC1.CC(C)(C)OC(=O)Nc1cc(Cl)c(Cl)cc1[N+](=O)[O-].CS(C)=O>>CC(C)(C)OC(=O)Nc1cc(N2CCCCC2)c(Cl)cc1[N+](=O)[O-]",
        "output": "105"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)CCc1cccc(OC(F)(F)F)c1.O.O=C1CCc2cc(OC(F)(F)F)ccc21.[K+].[OH-]>>O=C(O)CCc1cccc(OC(F)(F)F)c1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C.CC1(C)[C@@H]2CC[C@@]1(C)c1[nH]n(-c3ccccc3)c(=O)c12.CCCC[N+](CCCC)(CCCC)CCCC.CN(C)C=O.CO.COCCBr.ClCCl.O.[I-]>>COCCn1c2c(c(=O)n1-c1ccccc1)[C@H]1CC[C@]2(C)C1(C)C",
        "output": "577"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)c1cc2cc(-c3ccc(NC(C)=O)cc3)ccc2o1.Cl>>CCOC(=O)c1cc2cc(-c3ccc(N)cc3)ccc2o1",
        "output": "66"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1(C)Cc2cc(C(=O)O)ccc2NC1c1cccc(Br)c1.CN(C)CC(=O)O.CNCCNC.CS(C)=O.Cl.O=C([O-])[O-].[Cu]I.[K+].[K+]>>CNCCN(C)c1cccc(C2Nc3ccc(C(=O)O)cc3CC2(C)C)c1",
        "output": "953"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C(=O)O)c1ccc(S(C)(=O)=O)c(F)c1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F.NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1.On1nnc2ccccc21>>CC(C(=O)NCc1cc(C(F)(F)F)nn1-c1cccc(Cl)c1)c1ccc(S(C)(=O)=O)c(F)c1",
        "output": "230"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)CC(=O)c1cccc(-c2cnccn2)c1.Cc1cc(NC(=O)OC(C)(C)C)c(N)cc1C(F)(F)F>>Cc1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3cnccn3)c2)cc1C(F)(F)F",
        "output": "929"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.O.O=C([O-])[O-].O=Cc1c(O)cc(Cl)cc1Cl.[K+].[K+]>>COc1cc(Cl)cc(Cl)c1C=O",
        "output": "62"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN.Cc1ccc(-c2nc(C(=O)O)n(C)c2-c2ccc(C)cc2)cc1>>CNC(=O)c1nc(-c2ccc(C)cc2)c(-c2ccc(C)cc2)n1C",
        "output": "951"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cccc(C)n1.Cl.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.O=S(=O)(c1ccc(CCN(Cc2ccccc2)C[C@H](O)c2cccc(Cl)c2)cc1)c1cccc(O)c1>>O=S(=O)(c1ccc(CCN(Cc2ccccc2)C[C@H](O)c2cccc(Cl)c2)cc1)c1cccc(OS(=O)(=O)C(F)(F)F)c1",
        "output": "731"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)CCON=O.CN(C)C=O.Nc1c(Br)cc(F)c(Cl)c1Br>>Fc1cc(Br)cc(Br)c1Cl",
        "output": "324"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN(C)Cc1c(C(=O)NC2CCCCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(O)cc1.ClCCl.O=S(=O)(Cl)CCC(F)(F)F>>CN(C)Cc1c(C(=O)NC2CCCCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(OS(=O)(=O)CCC(F)(F)F)cc1",
        "output": "149"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CSc1ncc(C#N)c(Cl)n1.NC1CCC1.[Cl-].[Na+]>>CSc1ncc(C#N)c(NC2CCC2)n1",
        "output": "166"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCCCCCc1nnn(C(C(=O)OCC)c2ccccc2)n1.CCCCCCCCCCc1nnn(CC(=O)OCC)n1>>CCCCCCCCCCc1nnn(CC(=O)O)n1",
        "output": "7"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.Nc1cc(Br)ccn1.[NH4+].[OH-]>>CC(=O)Nc1cc(Br)ccn1",
        "output": "394"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)CC(CSc1ccc(C)cc1)Cc1ccccc1.CCOCC.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CCN(C)CC(CSc1ccc(C)cc1)Cc1ccccc1",
        "output": "112"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C(CCN1CCCC1)CC1CCCNC1.CCOC(C)=O.CCOCC.CO.ClCCl.O=C1Nc2cccnc2N(C(=O)Cl)c2ccccc21>>O=C1Nc2cccnc2N(C(=O)N2CCCC(CCCCN3CCCC3)C2)c2ccccc21",
        "output": "258"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNC1.C1CCOC1.CS(=O)(=O)c1nc(Oc2ccc(F)c(F)c2)c(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)n1>>Fc1ccc(Oc2nc(N3CCCC3)nc(-c3ccc(Cl)cc3Cl)c2-c2ccc(Cl)cc2)cc1F",
        "output": "679"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN.C[C@@H](c1ccc(-c2cccc(C(=O)O)n2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O>>CNC(=O)c1cccc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)n1",
        "output": "137"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1ccc(N2CCNCC2)c(F)c1.CSc1ccc(N2CCOCC2)c(C(=O)O)c1>>CSc1ccc(N2CCOCC2)c(C(=O)N2CCN(c3ccc(C(C)=O)cc3F)CC2)c1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1.CC(Cl)Cl.CN(C)c1ccncc1.Cc1ccc2ccccc2c1CN1C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)CNc2ccccc21.O.c1ccncc1>>CC(=O)Nc1ccc(S(=O)(=O)N2C[C@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(=O)N(Cc3c(C)ccc4ccccc34)c3ccccc32)cc1",
        "output": "791"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cl.O=C(O)Cc1cccc(F)c1>>COC(=O)Cc1cccc(F)c1",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1cccc(OCCC(C#N)NC(=O)[C@H](Cc2cccc(C)c2)NC(=O)C(c2ccccc2)c2ccccc2)c1.O.O.[Li]O>>Cc1cccc(C[C@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NC(C#N)CCOc2cccc(C(=O)O)c2)c1",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccc(CBr)cc1.CC#N.CC(C)(C)OC(=O)N1CCCN(C(=O)OC(C)(C)C)CCN(C(=O)OC(C)(C)C)CCCNCC1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCCN(C(=O)OC(C)(C)C)CCN(C(=O)OC(C)(C)C)CCCN(Cc2ccc(CBr)cc2)CC1",
        "output": "248"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C(O)CCCc1nc2ccccc2c(=O)[nH]1.O=c1[nH]c2cccnc2n1C1CCNCC1>>O=C(CCCc1nc2ccccc2c(=O)[nH]1)N1CCC(n2c(=O)[nH]c3cccnc32)CC1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CSc1nccc(N(C)c2cc(-c3ccccc3)cnn2)n1.ClCCl.O=C(OO)c1cccc(Cl)c1>>CN(c1cc(-c2ccccc2)cnn1)c1ccnc(S(C)=O)n1",
        "output": "595"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1ccc2nc(-c3ccc(N4CCNCC4)nc3)sc2c1.COc1ccc2nc(-c3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)nc3)sc2c1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+].[Na+].[OH-]>>COc1ccc2nc(-c3ccc(N4CCNCC4)nc3)sc2c1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(N)C1CN(C(=O)OC(C)(C)C)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cn1nc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)c2ccc(Cl)cc21.F[P-](F)(F)(F)(F)F>>CC(NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12)C1CN(C(=O)OC(C)(C)C)C1",
        "output": "737"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Nc1ccc2[nH]cnc2c1.S=C=Nc1ccc2nsnc2c1>>S=C(Nc1ccc2nsnc2c1)Nc1ccc2[nH]cnc2c1",
        "output": "474"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCC(=O)c1cc([N+](=O)[O-])ccc1O.CCc1ccc(CO)cc1.Cc1ccccc1.O.O=C(/N=N/C(=O)N1CCCCC1)N1CCCCC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCC(=O)c1cc([N+](=O)[O-])ccc1OCc1ccc(CC)cc1",
        "output": "347"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)c1ccc(-c2cccc(F)c2)cc1Nc1ccc(F)cc1.O=C(O)C(F)(F)F>>O=C(O)c1ccc(-c2cccc(F)c2)cc1Nc1ccc(F)cc1",
        "output": "752"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COc1ccc(CNS(=O)(=O)Cc2ccc(C(=O)N3CCOCC3)cc2)c(OC)c1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>COc1ccc(CNS(=O)(=O)Cc2ccc(CN3CCOCC3)cc2)c(OC)c1",
        "output": "215"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=O.Cc1ccccc1.Oc1cccc(O)c1>>O=Cc1c(O)cccc1O",
        "output": "451"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(=O)COc1cccc2cccnc12.NC[C@H](O)CN1CCc2ccccc2C1>>O=C(COc1cccc2cccnc12)NC[C@H](O)CN1CCc2ccccc2C1",
        "output": "64"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O.COC(=O)c1cncc(Oc2ccncc2[N+](=O)[O-])c1.[Fe].[NH4+].[OH-]>>COC(=O)c1cncc(Oc2ccncc2N)c1",
        "output": "269"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CO.O=C(O)CCCc1cn(S(=O)(=O)c2cccc([N+](=O)[O-])c2)c2ccccc12.[Pd]>>Nc1cccc(S(=O)(=O)n2cc(CCCC(=O)O)c3ccccc32)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)O[K].Clc1nc2ccccc2nc1Cl.OCCOc1ccccc1>>Clc1nc2ccccc2nc1OCCOc1ccccc1",
        "output": "209"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOC(C)=O.CN(C)C=O.OCc1c(Cl)ccnc1Br.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCc1c(Cl)ccnc1Br",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CO.Nc1ccc(-c2ccc(C(=O)O)cc2)cn1.O.O=C([O-])O.O=S(=O)(O)O.[Na+]>>COC(=O)c1ccc(-c2ccc(N)nc2)cc1",
        "output": "195"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)[Si](Cl)(C(C)C)C(C)C.CN(C)c1ccncc1.ClCCl.O.Oc1ccc2ccccc2c1Br.c1c[nH]cn1.c1ccncc1>>CC(C)[Si](Oc1ccc2ccccc2c1Br)(C(C)C)C(C)C",
        "output": "746"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cc(C(=O)O)ccn1.Nc1cnc(OCC(F)(F)F)c(-c2ccc(Cl)cc2)c1>>Cc1cc(C(=O)Nc2cnc(OCC(F)(F)F)c(-c3ccc(Cl)cc3)c2)ccn1",
        "output": "759"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)OC(C)=O.Nc1ccc(-c2nc3ccccc3o2)cc1.c1ccccc1>>CC(=O)Nc1ccc(-c2nc3ccccc3o2)cc1",
        "output": "6"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.Cl.N#Cc1ccc(-c2ccccc2)cc1NC(=O)c1cncc(-c2ccccc2)c1.[Cl-].[N-]=[N+]=[N-].[NH4+].[Na+]>>O=C(Nc1cc(-c2ccccc2)ccc1-c1nnn[nH]1)c1cncc(-c2ccccc2)c1",
        "output": "390"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1cccc(C2(c3ccccc3)c3ccccc3-c3ccccc32)c1.C1CCOC1.CCCCCC.CCOC(C)=O.COB(OC)OC.Cl.[Li]CCCC>>OB(O)c1cccc(C2(c3ccccc3)c3ccccc3-c3ccccc32)c1",
        "output": "789"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CS(=O)(=O)N1CCC(c2ncc(-c3ccc(N)cc3)s2)CC1.O=C=Nc1cc(F)c(F)cc1F>>CS(=O)(=O)N1CCC(c2ncc(-c3ccc(NC(=O)Nc4cc(F)c(F)cc4F)cc3)s2)CC1",
        "output": "473"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.COc1c(-c2cccnc2)c([C@H](C)N2C(=O)c3ccccc3C2=O)nc2ccc(F)cc12.NN>>COc1c(-c2cccnc2)c([C@H](C)N)nc2ccc(F)cc12",
        "output": "242"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)c1cccnc1-c1cccc([N+](=O)[O-])c1.[Pd]>>COC(=O)c1cccnc1-c1cccc(N)c1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(=O)(=O)Cl.Cc1ccccc1[C@H](CC(=O)c1ccc(=O)n(C)n1)c1ccc(C2CCNCC2)cc1>>Cc1ccccc1[C@H](CC(=O)c1ccc(=O)n(C)n1)c1ccc(C2CCN(S(C)(=O)=O)CC2)cc1",
        "output": "584"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc(C(=O)O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F.OCCN1CCOCC1>>COc1cc(C(=O)OCCN2CCOCC2)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F",
        "output": "33"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCc1nc(C)n(-c2cccc(OC)c2)c(=O)c1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CS(C)=O.O.O=C([O-])O.[Cl-].[NH3+]O.[Na+]>>CCCCc1nc(C)n(-c2cccc(OC)c2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCc2c(n(CCC(=O)O)c3ccccc23)CC1.CC(C)N=C=NC(C)C.CCOC(C)=O.CN(C)c1ccccn1.COc1ccc(N)cc1>>COc1ccc(NC(=O)CCn2c3c(c4ccccc42)CCN(C(=O)OC(C)(C)C)CC3)cc1",
        "output": "646"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccccc1.N#Cc1nc(Br)cnc1N.O.O=C([O-])[O-].OB(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.[K+].[K+].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1nc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cnc1N",
        "output": "876"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)C(=O)O.CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.Nc1ncnc2c1c(-c1ccc3c(c1)OC(c1ccccc1)CC3)cn2[C@H]1CC[C@@H](N)CC1>>CC(C)C(=O)N[C@H]1CC[C@@H](n2cc(-c3ccc4c(c3)OC(c3ccccc3)CC4)c3c(N)ncnc32)CC1",
        "output": "230"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C(NCC(=O)N1CCN(C(=O)c2ccccc2C(F)(F)F)CC1)c1ccc([N+](=O)[O-])cc1.[Pd]>>Nc1ccc(C(=O)NCC(=O)N2CCN(C(=O)c3ccccc3C(F)(F)F)CC2)cc1",
        "output": "28"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CN(C)C=O.N#CCCCl.O.Oc1ccc(O)cc1.[Na+].[OH-]>>N#CCCOc1ccc(O)cc1",
        "output": "74"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCc1cnc(Cl)nc1.O=C(c1ccc(-c2cnco2)c(F)c1)N(C1CCNCC1)C1CC1>>CCc1cnc(N2CCC(N(C(=O)c3ccc(-c4cnco4)c(F)c3)C3CC3)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.COC(=O)c1ccccc1NC(=O)CC1CCN(c2nnc3ccccc3n2)CC1.O.O=C([O-])[O-].[Na+].[Na+]>>O=C(CC1CCN(c2nnc3ccccc3n2)CC1)Nc1ccccc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(C)=O.Fc1cc(Cl)cnc1F.O.OCc1ccccc1.[H-].[Na+]>>Fc1cc(Cl)cnc1OCc1ccccc1",
        "output": "541"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CCOC(=O)c1ccc(CO)s1.CC1(C)CCC(C)(C)c2cc(C(=O)Cl)ccc21>>C=CCOC(=O)c1ccc(COC(=O)c2ccc3c(c2)C(C)(C)CCC3(C)C)s1",
        "output": "51"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCCCO.CCN(CC)CC.COc1cc2nccc(Oc3cc(C)c(N)cc3C)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.[Na+]>>C=CCCCOC(=O)Nc1cc(C)c(Oc2ccnc3cc(OC)c(OC)cc23)cc1C",
        "output": "960"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(-c2ccc(C(=O)O)cc2)c(C)n1.Nc1ccc2cccnc2c1>>Cc1ccc(-c2ccc(C(=O)Nc3ccc4cccnc4c3)cc2)c(C)n1",
        "output": "50"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(O)(CC(=O)O)C(F)(F)F.CS(=O)(=O)c1ccc(-c2ccc(OCC3CCNCC3)nc2)cc1>>CC(O)(CC(=O)N1CCC(COc2ccc(-c3ccc(S(C)(=O)=O)cc3)cn2)CC1)C(F)(F)F",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)Cc1ccc(N2Cc3c(Cl)ccc(OCc4ccccc4)c3C2=O)cc1.[Na+].[OH-]>>O=C(O)Cc1ccc(N2Cc3c(Cl)ccc(OCc4ccccc4)c3C2=O)cc1",
        "output": "7"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)c1cc(C2CC2)c2c(C)c(Cl)ccn2c1=O.OB(O)c1ccc(O)cc1>>COC(=O)c1cc(C2CC2)c2c(C)c(-c3ccc(O)cc3)ccn2c1=O",
        "output": "947"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCN1Cc2ccccc2C(=O)c2cc(CC(=O)OC)ccc21.CO.O.[Na+].[OH-]>>CCCN1Cc2ccccc2C(=O)c2cc(CC(=O)O)ccc21",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CN(C)c1ccncc1.COCc1ncc(CO)s1.CS(=O)(=O)Cl.ClCCl.N#N>>COCc1ncc(COS(C)(=O)=O)s1",
        "output": "0"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COc1cc(CO)cc(OC)c1CCCO.O=[Mn]=O>>COc1cc(C=O)cc(OC)c1CCCO",
        "output": "179"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)Cc1c(C)n(-c2cc(C)nc(-c3ccccc3)n2)c2ccc(OC)cc12.[Na+].[OH-]>>COc1ccc2c(c1)c(CC(=O)O)c(C)n2-c1cc(C)nc(-c2ccccc2)n1",
        "output": "7"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.C1COCCO1.Nc1ncc(-c2ccc3nccc(-c4ccncc4)c3c2)cc1S(=O)(=O)Cl.O=S(=O)(O)Cl.c1ccncc1>>Nc1ncc(-c2ccc3nccc(-c4ccncc4)c3c2)cc1S(=O)(=O)N1CCCCC1",
        "output": "169"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1cc(C)n(CC(=O)OCc2ccccc2)n1.[Pd]>>CCOC(=O)c1cc(C)n(CC(=O)O)n1",
        "output": "186"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.C1COCCN1.ClCCl.Fc1ccc(Br)cc1COCCCCBr>>Fc1ccc(Br)cc1COCCCCN1CCOCC1",
        "output": "73"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)C(C)(C)c1ccc(Br)cc1.CO.[Na+].[OH-]>>CC(C)(C(=O)O)c1ccc(Br)cc1",
        "output": "615"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCO.CCOC(=O)/C=C(C)/C=C/C(F)=C(/CC)c1cc2c(cc1OCC)C(C)(C)CC=C2C(C)(C)C.[Na+].[OH-]>>CCOc1cc2c(cc1/C(CC)=C(F)\\C=C\\C(C)=C\\C(=O)O)C(C(C)(C)C)=CCC2(C)C",
        "output": "122"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN1CCCNc2ccccc21.Cc1cc(C(=O)O)ccc1C#N>>CCN1CCCN(C(=O)c2ccc(C#N)c(C)c2)c2ccccc21",
        "output": "873"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CC(=O)Cl.CC#N.CCN(C(C)C)C(C)C.Nc1ncnc2c1c(-c1cnc3ccccc3c1)c1n2CC[C@@H](N)CC1.O.O=C([O-])O.[Na+]>>C=CC(=O)N[C@H]1CCc2c(-c3cnc4ccccc4c3)c3c(N)ncnc3n2CC1",
        "output": "298"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=C(CC)C(=O)c1ccc(OC(C)C(=O)OCC)c(Cl)c1Cl.CCO.O.O=C([O-])O.[Na+]>>C=C(CC)C(=O)c1ccc(OC(C)C(=O)O)c(Cl)c1Cl",
        "output": "7"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N1CCC(CC(=O)Nc2ccc(Br)cc2)CC1.Cc1ccc(B(O)O)cc1>>CC(=O)N1CCC(CC(=O)Nc2ccc(-c3ccc(C)cc3)cc2)CC1",
        "output": "837"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)c1ncc(C2=C(C(=O)OC(c3ccccc3)c3ccccc3)N3C(=O)C(NC(=O)Cc4cccs4)C3SC2)s1.O=CO>>CN(C)c1ncc(C2=C(C(=O)O)N3C(=O)C(NC(=O)Cc4cccs4)C3SC2)s1",
        "output": "228"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNCC1.CCO.O=C1CSC(=O)N1.[N-]=[N+]=NCCc1c(CCOc2ccc(C=O)cc2)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1>>[N-]=[N+]=NCCc1c(CCOc2ccc(C=C3SC(=O)NC3=O)cc2)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1",
        "output": "761"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cc(C(=O)O)cc2nc(C3(C)CC3)c(CC3CCC(F)(F)CC3)n12.Cl.NC1CCOCC1>>Cc1cc(C(=O)NC2CCOCC2)cc2nc(C3(C)CC3)c(CC3CCC(F)(F)CC3)n12",
        "output": "334"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1ccc(NC(=O)[C@@H]2N[C@@H](C[C@H](C)C(F)(F)F)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)c(OC)c1.Cl.O.[Na+].[OH-]>>COc1cc(C(=O)O)ccc1NC(=O)[C@@H]1N[C@@H](C[C@H](C)C(F)(F)F)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F",
        "output": "5"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.[N-]=[N+]=NC1CCc2cc3ccccn3c2C1.[Pd]>>NC1CCc2cc3ccccn3c2C1",
        "output": "89"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCn2c(c(C(=O)O)c3ccccc32)C1.CCN=C=NCCCN(C)C.CN(C)C=O.COc1ccccc1C1CCNCC1.Cl.On1nnc2ccccc21.[Cl-].[NH4+]>>COc1ccccc1C1CCN(C(=O)c2c3n(c4ccccc24)CCN(C(=O)OC(C)(C)C)C3)CC1",
        "output": "256"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.O=[Cr](=O)([O-])Cl.OCC(=C(c1ccc(F)cc1)c1ccc(F)cc1)n1cnnn1.c1cc[nH+]cc1>>O=CC(=C(c1ccc(F)cc1)c1ccc(F)cc1)n1cnnn1",
        "output": "183"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)COC(=O)Cl.CCN(CC)CC.Cc1nc(-c2cc(=O)oc3cc(C(=O)O)ccc23)cs1.O.[BH4-].[Na+]>>Cc1nc(-c2cc(=O)oc3cc(CO)ccc23)cs1",
        "output": "72"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.Cn1c(C(F)(F)F)cc(=O)n(-c2cc(Oc3ccccc3OCc3ccccc3)c(Cl)cc2F)c1=O.[Pd]>>Cn1c(C(F)(F)F)cc(=O)n(-c2cc(Oc3ccccc3O)c(Cl)cc2F)c1=O",
        "output": "23"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)CC1(NC(=O)c2ccc(N3CC(F)(F)C3)c(OCC3CC3)n2)CSC1.O.[Li+].[OH-]>>O=C(O)CC1(NC(=O)c2ccc(N3CC(F)(F)C3)c(OCC3CC3)n2)CSC1",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.Nc1ccc(F)c(Cl)c1.O=Cc1c(O)cncc1Cl>>Oc1cncc(Cl)c1C=Nc1ccc(F)c(Cl)c1",
        "output": "329"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)c1ccc(-c2cc3ncccc3c(Cl)n2)cc1.NCCCN.O>>CN(C)c1ccc(-c2cc3ncccc3c(NCCCN)n2)cc1",
        "output": "110"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(N)CNCCN.O=C1CCNCC1>>CC(C)(N)CNCCNC1CCNCC1",
        "output": "236"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCOC(=O)Cc1ccc2c(c1)[nH]c1c(C(N)=O)cc(F)c(Br)c12.O.[BH4-].[Cl-].[Li+].[NH4+]>>NC(=O)c1cc(F)c(Br)c2c1[nH]c1cc(CCO)ccc12",
        "output": "225"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.ClC(Cl)Cl.FC(F)(F)c1ccc(CNc2ncnc3c2CNCC3)cn1.N#Cc1cc(Cl)ccc1F>>N#Cc1cc(Cl)ccc1N1CCc2ncnc(NCc3ccc(C(F)(F)F)nc3)c2C1",
        "output": "26"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CSCCN1.CC#N.Clc1cncc(Cl)n1.O=C([O-])[O-].[K+].[K+]>>Clc1cncc(N2CCSCC2)n1",
        "output": "505"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCOC(C)=O.O=[N+]([O-])c1ccc(Oc2ccccc2)c(Cl)c1.[H][H].[Pt]>>Nc1ccc(Oc2ccccc2)c(Cl)c1",
        "output": "335"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1ccc2c(c1)c1ccccc1n2-c1ccccc1.c1ccc2c(c1)[nH]c1ccccc12>>Oc1ccc2c(c1)c1ccccc1n2-c1ccccc1",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C[C@H]1CN(c2nnc(-c3ccccc3)c3ccccc23)CCN1C(=O)OC(C)(C)C.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>C[C@H]1CN(c2nnc(-c3ccccc3)c3ccccc23)CCN1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CC(=O)c1cc(C#N)c(N2CCC(C(=O)O)CC2)nc1CN1CCCC1=O.CCN(C(C)C)C(C)C.ClCCl.F[P-](F)(F)(F)(F)F.NS(=O)(=O)Cc1ccccc1.O=S(=O)([O-])O.[K+]>>CC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccccc3)CC2)nc1CN1CCCC1=O",
        "output": "644"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(C)(Cc1ccc(O)cc1)Oc1ccc(OC)cc1.Cc1ccc(S(=O)(=O)OCCc2nc(-c3cccs3)oc2C)cc1>>CCOC(=O)C(C)(Cc1ccc(OCCc2nc(-c3cccs3)oc2C)cc1)Oc1ccc(OC)cc1",
        "output": "438"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CO.Cc1cn2ccccc2c1CCN.ClCCl.O=CCN(C(=O)CCN(CCc1cccc(Cl)c1Cl)C(=O)OCc1ccccc1)C1CCCCC1.[BH3-]C#N.[Na+]>>Cc1cn2ccccc2c1CCNCCN(C(=O)CCN(CCc1cccc(Cl)c1Cl)C(=O)OCc1ccccc1)C1CCCCC1",
        "output": "426"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCN=C=NCCCN(C)C.CCc1cc(C#N)cc(C)c1OC[C@@H](O)CN.Cl.O=C(O)CO.O=C([O-])O.On1nnc2ccccc21.[Na+]>>CCc1cc(C#N)cc(C)c1OC[C@@H](O)CNC(=O)CO",
        "output": "230"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.O=C(OCc1ccccc1)C1CCC(F)(F)C1.[Pd]>>O=C(O)C1CCC(F)(F)C1",
        "output": "186"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CNC.Cc1onc(-c2ccc(Cl)cc2)c1C(=O)O.O=S(Cl)Cl>>Cc1onc(-c2ccc(Cl)cc2)c1C(=O)N(C)C",
        "output": "975"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CN(C)C=O.CN1CCCC1.CNC1CNC1.Cl.Cl.Nc1nc(-n2cc(C(=O)O)c(=O)c3cc(F)c(F)c(Br)c32)ccc1F>>CNC1CN(c2c(F)cc3c(=O)c(C(=O)O)cn(-c4ccc(F)c(N)n4)c3c2Br)C1",
        "output": "676"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.C[Si](C)(C)[N-][Si](C)(C)C.Nc1ccc(Br)cn1.O.[Na+]>>CC(C)(C)OC(=O)Nc1ccc(Br)cn1",
        "output": "849"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1.[Na+].[OH-]>>CS(=O)(=O)Nc1cc([C@@H](O)CNC2CCN(c3ccc(C(=O)N[C@@H](Cc4ccccc4)C(=O)O)cc3)CC2)ccc1O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.ClCCl.F[P-](F)(F)(F)(F)F.Fc1cnc(Nc2ccc(N3CCOCC3)nc2)nc1NC1CCCNC1.N#CCC(=O)O>>N#CCC(=O)N1CCCC(Nc2nc(Nc3ccc(N4CCOCC4)nc3)ncc2F)C1",
        "output": "146"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.NC(=NO)c1ccccc1C(F)(F)F.O.O=C(O)Cn1nc(-c2ccc(Cl)s2)n(Cc2ccccc2F)c1=O.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>O=c1n(Cc2nc(-c3ccccc3C(F)(F)F)no2)nc(-c2ccc(Cl)s2)n1Cc1ccccc1F",
        "output": "926"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN1CCNCC1.COC(=O)c1ccc(F)cc1C.CS(C)=O.ClCCl.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(N2CCN(C)CC2)cc1C",
        "output": "773"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Br.CC(=O)O.O=C(N[C@@H]1C[C@@H](n2c(=O)oc3cccnc32)C1)OCc1ccccc1>>N[C@H]1C[C@H](n2c(=O)oc3cccnc32)C1",
        "output": "574"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CN.CN1Cc2c(-c3nc(CN4C(=O)c5ccccc5C4=O)no3)ncn2-c2ccccc2C1=O>>CN1Cc2c(-c3nc(CN)no3)ncn2-c2ccccc2C1=O",
        "output": "242"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.[N-]=[N+]=N[C@H]1CCCC[C@H]1N1CC[C@@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C1.[Pd]>>N[C@H]1CCCC[C@H]1N1CC[C@@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C1",
        "output": "89"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)(C)C(=O)Cl.CCCCC[C@H](O)/C=C/[C@@H]1[C@H]2CC(CCCCC(=O)O)S[C@H]2C[C@H]1O.CCN(CC)CC.OCCO>>CCCCC[C@H](O)/C=C/[C@@H]1[C@H]2CC(CCCCC(=O)OCCO)S[C@H]2C[C@H]1O",
        "output": "47"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COC(=O)C1(Nc2ccccc2)CCNCC1.ClC(Cl)Cl.O=C(Cl)OCc1ccccc1>>COC(=O)C1(Nc2ccccc2)CCN(C(=O)OCc2ccccc2)CC1",
        "output": "427"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1cccc(CSc2nc3ccccc3n2CC(=O)OC(C)(C)C)c1.ClCCl.O=C(O)C(F)(F)F>>COC(=O)c1cccc(CSc2nc3ccccc3n2CC(=O)O)c1",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.O=C(O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F.OCc1nc(C(F)(F)F)n2c1CNCC2.On1nnc2ccccc21>>O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(C(F)(F)F)nc(CO)c2C1",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(Cl)Cl.COc1cnc(N2CCOCC2)c2sc(NC(=O)Oc3ccccc3)nc12.OC1CCNCC1>>COc1cnc(N2CCOCC2)c2sc(NC(=O)N3CCC(O)CC3)nc12",
        "output": "525"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN[C@H](CN1CC[C@H](O)C1)c1ccccc1.COc1ccc(CN2C(=O)C(F)(F)c3ccc(CC(=O)O)cc32)cc1.On1nnc2ccccc21>>COc1ccc(CN2C(=O)C(F)(F)c3ccc(CC(=O)N(C)[C@H](CN4CC[C@H](O)C4)c4ccccc4)cc32)cc1",
        "output": "633"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)[C@@H]1C[C@@H](OCc2ccccc2)CN1C(=O)OC(C)(C)C.O.[BH4-].[Li+]>>CC(C)(C)OC(=O)N1C[C@H](OCc2ccccc2)C[C@H]1CO",
        "output": "430"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cc(C(=O)O)c(F)cc1N.F[P-](F)(F)(F)(F)F.NCC1(CN2CCCC2)CC1>>COc1cc(C(=O)NCC2(CN3CCCC3)CC2)c(F)cc1N",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OC(C)=O.CN1CCN(c2ccc(-c3n[nH]c(=O)c4ccccc34)cc2N)CC1.c1ccncc1>>CC(=O)Nc1cc(-c2n[nH]c(=O)c3ccccc23)ccc1N1CCN(C)CC1",
        "output": "6"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCc1coc(-c2ccc3ccccc3c2)n1.Oc1ccc(CCCn2ccnc2)cc1>>c1ccc2cc(-c3nc(COc4ccc(CCCn5ccnc5)cc4)co3)ccc2c1",
        "output": "760"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCCCc1nc(C2CC2)cc(=O)[nH]1.N#Cc1ccccc1-c1ccc(CBr)cc1.O=C([O-])[O-].[K+].[K+]>>CCCCc1nc(C2CC2)cc(=O)n1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "389"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CCCCC1.CC#N.O=C([O-])[O-].O=Cc1ccc(O)cc1.[K+].[K+].[Na+].[OH-]>>O=Cc1ccc(OCC2CCCCC2)cc1",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=CCBr.CC(=O)c1cc(C(C)=O)c(O)cc1N.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>C=CCOc1cc(N)c(C(C)=O)cc1C(C)=O",
        "output": "77"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccccc1.CC(C)=O.FC(F)(F)c1cccc(C2CCCNC2)c1.O=[Ag]>>FC(F)(F)c1cccc(C2CCCN(Cc3ccccc3)C2)c1",
        "output": "248"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BCl.C1CCOC1.C=CCCCCCC[Si](C)(C)CC[SiH](C)C.CSC.OO>>C[SiH](C)CC[Si](C)(C)CCCCCCCCO",
        "output": "465"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1=CCC2CNC(C1)CN2c1ccc2c(c1)OCCO2.CCO.Cc1cc2c(OCC3CO3)cccc2[nH]1.ClC(Cl)Cl>>Cc1cc2c(OCC(O)CN3CC4CC=CCC3CN4c3ccc4c(c3)OCCO4)cccc2[nH]1",
        "output": "76"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1c1cc(C)nn1-c1ccnc2ccccc12.[Li+].[OH-]>>Cc1cc(N2C[C@H](S(=O)(=O)c3ccccc3C(F)(F)F)C[C@H]2C(=O)O)n(-c2ccnc3ccccc23)n1",
        "output": "88"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "BrCc1ccccc1.CCOC(=O)c1c(N2CCN(C(=O)c3ccco3)CC2)c2cc(F)cnc2[nH]c1=O>>CCOC(=O)c1c(N2CCN(C(=O)c3ccco3)CC2)c2cc(F)cnc2n(Cc2ccccc2)c1=O",
        "output": "389"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=C(Br)CCO.CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CN(C)c1ccncc1.c1c[nH]cn1>>C=C(Br)CCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C",
        "output": "602"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COc1ccc(N2CCNCC2)cc1.Cl.Cl.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)cc1.[K+].[K+]>>COc1ccc(N2CCN(c3ccc([N+](=O)[O-])cc3)CC2)cc1",
        "output": "105"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCC(CC)C(=O)O.COc1ccccc1.Cc1ccccc1.O.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Dy+3]>>CCC(CC)C(=O)c1ccc(OC)cc1",
        "output": "435"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CS(=O)(=O)Cl.O.OCCCc1ccc(Cl)cc1>>CS(=O)(=O)OCCCc1ccc(Cl)cc1",
        "output": "0"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.Cc1ncnc2c1c(NCc1ccc([N+](=O)[O-])cc1)cc(=O)n2OCc1ccccc1.ClC(Cl)Cl.O.O=C([O-])O.[Cl-].[Fe].[NH4+].[Na+]>>Cc1ncnc2c1c(NCc1ccc(N)cc1)cc(=O)n2OCc1ccccc1",
        "output": "507"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CC(=O)NC1CCNCC1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.O=c1cc(OCc2cccs2)ccn1CCc1ccc(CO)cc1>>CC(=O)NC1CCN(Cc2ccc(CCn3ccc(OCc4cccs4)cc3=O)cc2)CC1",
        "output": "765"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl.OCc1ccccc1SCCCN1CCN(c2ccccc2)CC1>>O=Cc1ccccc1SCCCN1CCN(c2ccccc2)CC1",
        "output": "179"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc(C(O)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F.ClCCl.[Mn+4].[O-2].[O-2]>>COc1cc(C(=O)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F",
        "output": "59"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CN(C)c1ccncc1.ClCCl.O=C(O)CCCCCCCCCCS.O=[N+]([O-])c1ccccc1CO>>O=C(CCCCCCCCCCS)OCc1ccccc1[N+](=O)[O-]",
        "output": "17"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCn1c2ccccc2c2cc(CNC(=O)C(C)CN)ccc21.N#Cc1ccc(C(=O)O)cc1>>CCn1c2ccccc2c2cc(CNC(=O)C(C)CNC(=O)c3ccc(C#N)cc3)ccc21",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.N#Cc1cc(C=O)ccc1Oc1ccc(Cl)c(C(F)(F)F)c1.[BH4-].[Na+]>>N#Cc1cc(CO)ccc1Oc1ccc(Cl)c(C(F)(F)F)c1",
        "output": "356"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCOC(=O)c1cnn(C2COCCOC2)c1-c1ccc(Br)cc1[N+](=O)[O-].CCOC(C)=O.COc1ncc(C)c(B(O)O)c1C.O>>CCOC(=O)c1cnn(C2COCCOC2)c1-c1ccc(-c2c(C)cnc(OC)c2C)cc1[N+](=O)[O-]",
        "output": "904"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.CN.COc1ccc(N(C)c2nc(Cl)nc3ccc(OC)cc23)cc1.Cl.O=C([O-])[O-].[K+].[K+]>>CNc1nc(N(C)c2ccc(OC)cc2)c2cc(OC)ccc2n1",
        "output": "544"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(C)CC(CCCCNc2nc(Cl)nc(NCCCCC3CC(C)(C)N(OC4CCCCC4)C(C)(C)C3)n2)CC(C)(C)N1OC1CCCCC1.OCCNCCO>>CC1(C)CC(CCCCNc2nc(NCCCCC3CC(C)(C)N(OC4CCCCC4)C(C)(C)C3)nc(N(CCO)CCO)n2)CC(C)(C)N1OC1CCCCC1",
        "output": "214"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(Br)C(=O)Cl.CCOC(C)=O.Cl.OCCO.c1ccncc1>>CC(Br)C(=O)OCCO",
        "output": "126"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NCCOCCOCCOCCNC(=O)CCCCC(=O)O.CN(C)C=O.COC(=O)N1C(=O)C=CC1=O.Cl>>NCCOCCOCCOCCNC(=O)CCCCC(=O)O",
        "output": "538"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCI.CCOC(=O)c1nnc2c(-c3ccc(Cl)c(OC)c3)c(-c3ccncc3)nn2c1C1CCNCC1.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)c1nnc2c(-c3ccc(Cl)c(OC)c3)c(-c3ccncc3)nn2c1C1CCN(CC)CC1",
        "output": "184"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.Cc1ccccc1.N#CSc1nc(Cl)ncc1[N+](=O)[O-].Nc1ccc(Cl)c(Cl)c1>>N#CSc1nc(Nc2ccc(Cl)c(Cl)c2)ncc1[N+](=O)[O-]",
        "output": "808"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.O=C(O)c1cc(S(=O)(=O)Cl)ccc1Br.[H-].[Na+].c1ccc2[nH]ccc2c1>>O=C(O)c1cc(S(=O)(=O)n2ccc3ccccc32)ccc1Br",
        "output": "648"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(CN=[N+]=[N-])Cn1cc([N+](=O)[O-])nc1Cl.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC(CN)Cn1cc([N+](=O)[O-])nc1Cl",
        "output": "89"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cnc(-n2c(=S)[nH]c3cc(C(=O)O)ccc3c2=O)nc1OC.F[P-](F)(F)(F)(F)F.NCc1cccc(Cl)c1>>COc1cnc(-n2c(=S)[nH]c3cc(C(=O)NCc4cccc(Cl)c4)ccc3c2=O)nc1OC",
        "output": "753"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc(F)c(Oc2cc(Cl)cc(C#N)c2)c1Cl.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>N#Cc1cc(Cl)cc(Oc2c(F)ccc(CBr)c2Cl)c1",
        "output": "29"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCC(NC2CCCCC2)CC1.CN(C)C=O.COC(=O)[C@@H](N)Cc1ccccc1.C[C@@H](NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)O>>COC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)OC(C)(C)C",
        "output": "129"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cccc(CCC(=O)Cl)c1.Nc1ccc(F)cc1>>COc1cccc(CCC(=O)Nc2ccc(F)cc2)c1",
        "output": "9"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CCCC1=O.COc1ccc2c(c1)CC(=O)CC2.O.O=C([O-])[O-].Sc1ccccc1.[K+].[K+].[Na+].[OH-]>>O=C1CCc2ccc(O)cc2C1",
        "output": "48"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cc1ncsc1CCCCCCC(O)C(=O)O.Cl.NCc1nnc(-c2ccc(OCc3cccc(F)c3)cc2)s1.O.On1nnc2ccccc21>>Cc1ncsc1CCCCCCC(O)C(=O)NCc1nnc(-c2ccc(OCc3cccc(F)c3)cc2)s1",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCCCCCCBr.Cc1ccc(SCCCO)cc1.O.[Na+].[OH-]>>Cc1ccc(SCCCOCCCCCCBr)cc1",
        "output": "95"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NCC1(CC2CC2)CCN(C(=O)OCc2ccccc2)CC1.CO.[Pd]>>CC(C)(C)OC(=O)NCC1(CC2CC2)CCNCC1",
        "output": "428"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COc1ccc(CC(NC(=O)OC(C)(C)C)c2nc3ccccc3[nH]2)c(F)c1.Cl.ClCCl.N#N>>COc1ccc(CC(N)c2nc3ccccc3[nH]2)c(F)c1",
        "output": "538"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O=C(O)c1cccc(C(F)(F)F)c1Cl.c1ccc(-n2cnc3c2CCNC3)nc1>>O=C(c1cccc(C(F)(F)F)c1Cl)N1CCc2c(ncn2-c2ccccn2)C1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CN(CCN1CCSc2cc([N+](=O)[O-])ccc21)CC(=O)OC(C)(C)C.[Pd]>>CN(CCN1CCSc2cc(N)ccc21)CC(=O)OC(C)(C)C",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.Cc1c(C(=O)N(C)c2ccc(OCc3ccccc3)cc2)cc(-c2cc3c(cc2C(=O)N2Cc4ccccc4C[C@H]2C)CN(C(=O)Cc2ccccc2)C3)n1C.[Pd]>>Cc1c(C(=O)N(C)c2ccc(O)cc2)cc(-c2cc3c(cc2C(=O)N2Cc4ccccc4C[C@H]2C)CN(C(=O)Cc2ccccc2)C3)n1C",
        "output": "698"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.Cc1ccc(Cl)cc1C(=O)O.Cc1ccccc1.NC1CC1.O=C(Cl)C(=O)Cl>>Cc1ccc(Cl)cc1C(=O)NC1CC1",
        "output": "334"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Br.BrBr.CC(=O)O.CC(=O)c1c(C)nc2ccccn12.CCOCC>>Cc1nc2ccccn2c1C(=O)CBr",
        "output": "173"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CP(C)(=O)c1ccc(Nc2cc(Cl)ncn2)cc1.NCC12CC3CC(CC(C3)C1)C2>>CP(C)(=O)c1ccc(Nc2cc(NCC34CC5CC(CC(C5)C3)C4)ncn2)cc1",
        "output": "166"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CCc1cccc(-c2c(Cl)cccc2C(O)(CCCNC(=O)OC)[C@@H]2CCCN(C(=O)N3CCC(CN)CC3)C2)c1.ClCCl.NC(=O)[O-].O=[N+]([O-])c1ccccc1S(=O)(=O)Cl>>CCc1cccc(-c2c(Cl)cccc2C(O)(CCCNC(=O)OC)[C@@H]2CCCN(C(=O)N3CCC(CNS(=O)(=O)c4ccccc4[N+](=O)[O-])CC3)C2)c1",
        "output": "43"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.C=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CNC1CN(c2c(-c3ccccc3)c(C)c(C#N)c3nc4ncccc4n23)C1.ClCCl.[Na+]>>Cc1c(-c2ccccc2)c(N2CC(N(C)C)C2)n2c(nc3ncccc32)c1C#N",
        "output": "217"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1nc(C(=O)CCCC#C[Si](C)(C)C)nc(C(C)(C)C)c1O.CN(C)C=O.O.O.[F-].[K+]>>C#CCCCC(=O)c1nc(C(C)(C)C)c(O)c(C(C)(C)C)n1",
        "output": "337"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=CC[C@@H](C[C@H](NC(=O)OC(C)(C)C)C(=O)OC)C(=O)OC.O.OO.[Na+].[OH-]>>COC(=O)[C@@H](CCCO)C[C@H](NC(=O)OC(C)(C)C)C(=O)OC",
        "output": "465"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.Cl.ClCCl.NC(=O)[C@H]1CCCNC1.O=C(Cl)c1ccc(F)c(F)c1>>NC(=O)[C@H]1CCCN(C(=O)c2ccc(F)c(F)c2)C1",
        "output": "201"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCC(CC(=O)O)N1C(=O)c2ccccc2C1=O.NNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=NC1.O=C(n1ccnc1)n1ccnc1>>CCC(CC(=O)NNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=NC1)N1C(=O)c2ccccc2C1=O",
        "output": "459"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC)C1CCNC1.C[C@H]1CCC[C@@](O)(CNC(=O)c2c(Cl)ccc3nc(Cl)ccc23)C1>>CCN(CC)C1CCN(c2ccc3c(C(=O)NC[C@]4(O)CCC[C@H](C)C4)c(Cl)ccc3n2)C1",
        "output": "220"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O.O=C(C1CCOCC1)N1CC[C@H](O)C1>>CS(=O)(=O)O[C@H]1CCN(C(=O)C2CCOCC2)C1",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrBr.CC(=O)C(C)(C)CF.CCOCC.O>>CC(C)(CF)C(=O)CBr",
        "output": "173"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.Cn1cc(-c2ccncc2)c(-c2ccc(C#C[Si](C)(C)C)cn2)n1.O.[F-]>>C#Cc1ccc(-c2nn(C)cc2-c2ccncc2)nc1",
        "output": "337"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.C[C@H](N)Cn1ccc(-c2cc(F)c(C#N)c(Cl)c2)n1.Cc1nc(C(=O)O)cn1C[C@H](C)O.ClCCl>>Cc1nc(C(=O)N[C@@H](C)Cn2ccc(-c3cc(F)c(C#N)c(Cl)c3)n2)cn1C[C@H](C)O",
        "output": "697"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1ccc(CC(C)NC(C)=O)cc1.C1CCNCC1.CC(C)=O.COc1ccc(Br)c(OC)c1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O>>COc1ccc(C#Cc2ccc(CC(C)NC(C)=O)cc2)c(OC)c1",
        "output": "659"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccc(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(C(F)(F)F)c1.[Pd]>>Nc1ccc(-c2ccc(N)cc2C(F)(F)F)c(C(F)(F)F)c1",
        "output": "204"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.O=CCCc1ccc(F)cc1.O=Cc1ccccc1Cl.O=S(=O)(O)O.[Na+].[OH-]>>O=CC(=Cc1ccccc1Cl)Cc1ccc(F)cc1",
        "output": "85"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(CC(O)(CO)CC1CCCCC1)c1ccccc1.CCN(CC)CC.CS(C)=O>>CC(C)(CC(O)(C=O)CC1CCCCC1)c1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(CO)Cc1ccccc1.CCN(CC)CC.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)(C=O)Cc1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1ccc(Oc2c(C)cc([N+](=O)[O-])cc2C)cc1.ClCCl.Cl[Ti](Cl)(Cl)Cl.O=C(Cl)c1ccc(F)cc1>>COc1ccc(Oc2c(C)cc([N+](=O)[O-])cc2C)cc1C(=O)c1ccc(F)cc1",
        "output": "61"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClCCl.Cl[Pd]Cl.Nc1ccccc1I.OB(O)c1ccc(Cl)cc1.[Fe+2].[Na+].[OH-].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>Nc1ccccc1-c1ccc(Cl)cc1",
        "output": "855"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cc1nc(C)c(-c2c[nH]c(=O)[nH]c2=O)o1.ClCCCCBr.O.O=C([O-])[O-].[K+].[K+]>>Cc1nc(C)c(-c2cn(CCCCCl)c(=O)[nH]c2=O)o1",
        "output": "327"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C#CCCO.CCNCC.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Cn1nc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(I)ccc21.I[Cu]I>>Cn1nc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(C#CCCO)ccc21",
        "output": "664"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CC(C)(F)c1noc(C2CCNCC2)n1.CCN(C(C)C)C(C)C.Cl.Fc1c(Cl)ncnc1Cl.O>>CC(C)(F)c1noc(C2CCN(c3ncnc(Cl)c3F)CC2)n1",
        "output": "296"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N1CCC(CC(=O)Cl)CC1.Nc1ccc(-c2cc(Cl)cc(Cl)c2)cn1>>CC(=O)N1CCC(CC(=O)Nc2ccc(-c3cc(Cl)cc(Cl)c3)cn2)CC1",
        "output": "332"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.C[C@H](O)CN.Cn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)O)ccc21.F[P-](F)(F)(F)(F)F>>C[C@H](O)CNC(=O)c1ccc2c(c1)nc(Nc1nc3ccc(OC(F)(F)F)cc3s1)n2C",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCNc1ccccc1.CN1CCOCC1.COC(=O)Cl.ClCCl.O.O=C(O)CCCOc1cccc2c1CCC(=O)N2>>CCN(C(=O)CCCOc1cccc2c1CCC(=O)N2)c1ccccc1",
        "output": "315"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)Oc1ccc(-c2ccc3oc(-c4cccc(N)c4)nc3c2)cc1.O=S(=O)(Cl)c1cc(Cl)ccc1Cl>>CC(C)Oc1ccc(-c2ccc3oc(-c4cccc(NS(=O)(=O)c5cc(Cl)ccc5Cl)c4)nc3c2)cc1",
        "output": "68"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.Cc1cc(Cl)ccc1N=C=O.Cl.NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O>>Cc1cc(Cl)ccc1NC(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O",
        "output": "814"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cc(N)cc(-c2cccc(F)c2)c1.O=N[O-].[I-].[K+].[Na+]>>COc1cc(I)cc(-c2cccc(F)c2)c1",
        "output": "200"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)c1ccccc1-c1ccc(CC23CCCCN2C(=O)N(c2cc(Cl)cc(Cl)c2)C3=O)cc1.Cl.O.[Na+].[OH-]>>O=C(O)c1ccccc1-c1ccc(CC23CCCCN2C(=O)N(c2cc(Cl)cc(Cl)c2)C3=O)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)O.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.NC1([C@@H]2CCN(C(c3ccccc3)c3ccccc3)C2)CC1.[Na+].[OH-]>>CC(C)(C)OC(=O)NC1([C@@H]2CCN(C(c3ccccc3)c3ccccc3)C2)CC1",
        "output": "631"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=O.CC(=O)O.CCOC(C)=O.CO.O=C(c1ccc(N2CCNCC2)cc1Cl)N1CCCCc2ccccc21.[BH3-]C#N.[Na+]>>CN1CCN(c2ccc(C(=O)N3CCCCc4ccccc43)c(Cl)c2)CC1",
        "output": "217"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.O=C1CCC(=O)N1Cl.Oc1ccc2cc(Br)ccc2c1>>Oc1ccc2cc(Br)ccc2c1Cl",
        "output": "121"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=CC(=O)Nc1ccc(N)cc1.CCN(C(C)C)C(C)C.Clc1ncnc(Nc2ccc3c(cnn3Cc3ccccc3)c2)n1>>C=CC(=O)Nc1ccc(Nc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)n2)cc1",
        "output": "592"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.NO.O=Cc1ccc(Br)c2cnccc12>>ON=Cc1ccc(Br)c2cnccc12",
        "output": "30"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(c1ccc2c(c1)nc(NC1CCCCC1)n2C)c1ccnc(Cl)n1.CS(=O)(=O)Cc1ccc(N)cc1>>CN(c1ccc2c(c1)nc(NC1CCCCC1)n2C)c1ccnc(Nc2ccc(CS(C)(=O)=O)cc2)n1",
        "output": "808"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCN1.CC(C)N1CCN(C(=O)c2ccc3[nH]c(C(=O)O)cc3c2)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cl.F[B-](F)(F)F>>CC(C)N1CCN(C(=O)c2ccc3[nH]c(C(=O)N4CCOCC4)cc3c2)CC1",
        "output": "605"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC1CCCN1CCCOc1ccc(-c2nc3c(s2)CCCC3NC(=O)OCc2ccccc2)cc1.Cl.O>>CC1CCCN1CCCOc1ccc(-c2nc3c(s2)CCCC3N)cc1",
        "output": "574"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COC(=O)C(Oc1ccc(C(C)(C)C)cc1)c1ccc(OCC(C)Oc2ccc(Cl)cc2)cc1.Cl.O.[K+].[OH-]>>CC(COc1ccc(C(Oc2ccc(C(C)(C)C)cc2)C(=O)O)cc1)Oc1ccc(Cl)cc1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCCN(CCC)C(=O)c1cc(C(=O)OC)cc(-c2nccn2COCC)c1.CO.O.[Li+].[OH-]>>CCCN(CCC)C(=O)c1cc(C(=O)O)cc(-c2nccn2COCC)c1",
        "output": "247"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.CCCCCCC.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.CCOC(C)=O.CN(C)Cc1c(OCC2CC2)ccc2c(CCC3CCNCC3)noc12.Fc1ccccn1.O.O.[F-].[Na+].[OH-]>>CN(C)Cc1c(OCC2CC2)ccc2c(CCC3CCN(c4ccccn4)CC3)noc12",
        "output": "756"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCC1(CC(=O)OCC)OCCc2c1[nH]c1c(C)ccc(C(=O)NC)c21.CO.[Na+].[OH-]>>CCCC1(CC(=O)O)OCCc2c1[nH]c1c(C)ccc(C(=O)NC)c21",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)CBr.CN(C)C=O.N#CCc1ccc(O)cc1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)COc1ccc(CC#N)cc1",
        "output": "393"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Nc1nccc(Nc2ccc(C(F)(F)F)cn2)c1[N+](=O)[O-].[Pd]>>Nc1nccc(Nc2ccc(C(F)(F)F)cn2)c1N",
        "output": "269"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)O.COC(=O)c1ccc(Cl)nn1.Cl.FC(F)(F)c1ccccc1OC1CNC1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(N2CC(Oc3ccccc3C(F)(F)F)C2)nn1",
        "output": "406"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOc1cc(Cc2ccccn2)ccc1CCC(=O)OC.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>CCOc1cc(Cc2ccccn2)ccc1CCCO",
        "output": "343"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)Cn1c(C)c(Cc2ccc(=O)n(Cc3cccc(F)c3F)c2)c2cc(Cl)ccc21.O.[Li+].[OH-]>>Cc1c(Cc2ccc(=O)n(Cc3cccc(F)c3F)c2)c2cc(Cl)ccc2n1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.Nc1ccc(Cl)cn1.O=C(CBr)c1ccc(Cl)cc1.[Na+].[OH-]>>Clc1ccc(-c2cn3cc(Cl)ccc3n2)cc1",
        "output": "508"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(Cl)OC(=O)Cl.CCN(CC)CC.CCOC(=O)c1cc2cc(C3(Cc4ccccc4)CCN(Cc4ccccc4)C3)ccc2n1C(=O)OC(C)(C)C.ClCCCl>>CCOC(=O)c1cc2cc(C3(Cc4ccccc4)CCNC3)ccc2n1C(=O)OC(C)(C)C",
        "output": "84"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(F)C(=O)O.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cn1c(Nc2c(Cl)ccc(CN)c2Cl)nc2cc(C(=O)O)c(N3CCC(C(F)(F)F)CC3)cc21.F[B-](F)(F)F>>Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)F)c2Cl)nc2cc(C(=O)O)c(N3CCC(C(F)(F)F)CC3)cc21",
        "output": "599"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.Nc1cccc(-c2cn3ccccc3n2)c1.O=C(O)c1cc2cc(I)ccc2oc1=O>>O=C(Nc1cccc(-c2cn3ccccc3n2)c1)c1cc2cc(I)ccc2oc1=O",
        "output": "799"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.CCCC[N+](CCCC)(CCCC)CCCC.O=C(CCCBr)OCc1ccccc1.O=C([O-])O.[Na+].[OH-]>>CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)OCCCC(=O)OCc1ccccc1",
        "output": "416"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.C[C@@H](N[C@@H]1CCNC1)c1cccc2ccccc12.Cl.Cl.Clc1nccnc1Cl.O=C([O-])[O-].[K+].[K+]>>C[C@@H](N[C@@H]1CCN(c2nccnc2Cl)C1)c1cccc2ccccc12",
        "output": "505"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.CN(C)C=O.COc1c(F)c(I)c(C)c(C#N)c1NC(=O)C(C)(C)C.OB(O)c1ccccc1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COc1c(F)c(-c2ccccc2)c(C)c(C#N)c1NC(=O)C(C)(C)C",
        "output": "855"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1ccccc1.CN(C)C=O.O=C(O)CC1CC1.O=C([O-])[O-].[K+].[K+]>>O=C(CC1CC1)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)c1cnc(C)n1C1CCCC1.CN(C)C=O.COC(OC)N(C)C>>Cc1ncc(C(=O)/C=C/N(C)C)n1C1CCCC1",
        "output": "898"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(Cn2nc(NC3CCN(C)CC3)c3c(Oc4cc(Cl)c(NC(=O)c5ccnn(-c6ccc(F)cc6)c5=O)cc4F)ccnc32)cc1.O=C(O)C(F)(F)F>>CN1CCC(Nc2n[nH]c3nccc(Oc4cc(Cl)c(NC(=O)c5ccnn(-c6ccc(F)cc6)c5=O)cc4F)c23)CC1",
        "output": "978"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC[C@@H]1C[C@@H](Oc2cccc3ccc(-c4nnc5ccccn45)nc23)CCN1C(=O)OC(C)(C)C.Cl.ClC(Cl)Cl>>COC[C@@H]1C[C@@H](Oc2cccc3ccc(-c4nnc5ccccn45)nc23)CCN1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(N2C(=O)N(c3ccccc3)c3nc(Cl)ncc3C2C)c(F)c1.Nc1ccccc1>>COc1ccc(N2C(=O)N(c3ccccc3)c3nc(Nc4ccccc4)ncc3C2C)c(F)c1",
        "output": "808"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN(C/C=C/C(=O)O)C1CC1.CN1CCc2sc(NC(=O)c3ccc(Oc4ccnc5[nH]nc(N[C@@H]6CCCNC6)c45)cc3)nc2C1.F[P-](F)(F)(F)(F)F>>CN1CCc2sc(NC(=O)c3ccc(Oc4ccnc5[nH]nc(N[C@@H]6CCCN(C(=O)/C=C/CN(C)C7CC7)C6)c45)cc3)nc2C1",
        "output": "870"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCNS(=O)(=O)c1ccc(N2CCC(=O)CC2)cc1.CS(=O)(=O)Nc1cc([C@@H](O)CN)ccc1O>>CCCCNS(=O)(=O)c1ccc(N2CCC(NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)CC2)cc1",
        "output": "236"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C(=O)O)c1ccc2c(c1)Cc1ccccc1O2.CCN(CC)CC.CCOC(=O)Cl.CCOC(=O)OC(=O)C(C)c1ccc2c(c1)Cc1ccccc1O2.CCOC(=O)[O-].O.[BH4-].[Na+]>>CC(CO)c1ccc2c(c1)Cc1ccccc1O2",
        "output": "231"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.CC(CO)(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1.ClCCl>>CC(C=O)(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.C[C@H]1CC(c2ccncc2[N+](=O)[O-])=C[C@@H](O[Si](C)(C)C(C)(C)C)[C@@]1(O)CO.ClCCl>>C[C@H]1CC(c2ccncc2[N+](=O)[O-])=C[C@@H](O[Si](C)(C)C(C)(C)C)[C@@]1(O)C=O",
        "output": "142"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cn1nc(NCC(=O)NC2CNC2)c2cc(C(F)(F)F)ccc21.O=C(O)C(F)(F)F.O=C1CCC(O)(c2cncs2)CC1>>Cn1nc(NCC(=O)NC2CN(C3CCC(O)(c4cncs4)CC3)C2)c2cc(C(F)(F)F)ccc21",
        "output": "187"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Cl.Cc1[nH]c2c(-c3ccc(F)cc3OCC3CC3)ncnc2c1C(=O)N[C@@H]1CCNC1.Cl>>CC(=O)N1CC[C@@H](NC(=O)c2c(C)[nH]c3c(-c4ccc(F)cc4OCC4CC4)ncnc23)C1",
        "output": "125"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)Cn1nc(N)cc1C.O=C(O)C(CC1CCOCC1)n1ncc(Oc2c(F)cccc2F)cc1=O>>CC(=O)OC(C)Cn1nc(NC(=O)C(CC2CCOCC2)n2ncc(Oc3c(F)cccc3F)cc2=O)cc1C",
        "output": "795"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCc1cc(C)c(-c2nc3c([nH]2)COCC3C)cc1C(=O)O.CN(C)C=O.CN(C)c1ccncc1.Cl.ClCCCl.ClCCl.N#Cc1ccc(C2CCNCC2)cc1>>CCc1cc(C)c(-c2nc3c([nH]2)COCC3C)cc1C(=O)N1CCC(c2ccc(C#N)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "N.O=C(O)CC1(NC(=O)c2ccc(C3(O)CCC3)c(OCC3CC3)n2)CS(=O)(=O)C1.O=C(n1ccnc1)n1ccnc1>>NC(=O)CC1(NC(=O)c2ccc(C3(O)CCC3)c(OCC3CC3)n2)CS(=O)(=O)C1",
        "output": "313"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.O=C(O)Cc1ccc(Cl)cc1.O=S(=O)(O)O>>CCOC(=O)Cc1ccc(Cl)cc1",
        "output": "17"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)O)C(CCC(=O)OCc3ccccc3)C2)nc1C.NS(=O)(=O)Cc1ccc(F)cc1F>>CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccc(F)cc3F)C(CCC(=O)OCc3ccccc3)C2)nc1C",
        "output": "644"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CCN(CC)C(=O)/C(C#N)=C/c1cc(O)c(O)c([N+](=O)[O-])c1.CCOC(C)=O.CN(C)c1ccncc1.COC(=O)[C@H](Cc1ccc(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c1)NC(=O)CCC(=O)O>>CCN(CC)C(=O)/C(C#N)=C/c1cc(OC(=O)CCC(=O)N[C@@H](Cc2ccc(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c2)C(=O)OC)c(O)c([N+](=O)[O-])c1",
        "output": "108"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CC(=O)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOCC.FC(F)(F)CNc1cc(Br)cc(Nc2nccc(C(F)(F)F)n2)c1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[K+].[Pd].[Pd]>>CC1(C)OB(c2cc(NCC(F)(F)F)cc(Nc3nccc(C(F)(F)F)n3)c2)OC1(C)C",
        "output": "942"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)CC(C)C.CCCC[N+](CCCC)(CCCC)CCCC.N#N.O=C([O-])[O-].O=c1[nH]c2ccccc2n1CCCl.[I-].[Na+].[Na+].c1ccc2c3c([nH]c2c1)CNCC3>>O=c1[nH]c2ccccc2n1CCN1CCc2c([nH]c3ccccc23)C1",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccccc1C(=O)c1cccc2c1ccn2C.Cl.ClCCl.c1ccncc1>>Cn1ccc2c(C(=O)c3ccccc3O)cccc21",
        "output": "48"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccc(C(=O)CC(C)(C)C)cc1.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>CC(C)(C)CC(=O)c1ccc(CBr)cc1",
        "output": "29"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1ccc(C2(C(F)(F)F)CC(c3cc(Cl)cc(Cl)c3)=NO2)cc1[N+](=O)[O-].O.[Li+].[OH-]>>O=C(O)c1ccc(C2(C(F)(F)F)CC(c3cc(Cl)cc(Cl)c3)=NO2)cc1[N+](=O)[O-]",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)=O.Cl.O=C([O-])O.OC1(c2ccc3c(c2)OCO3)CCC2(CC1)OCCO2.[Na+]>>O=C1CCC(O)(c2ccc3c(c2)OCO3)CC1",
        "output": "251"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.Nc1cccc([C@@H]2CCN(Cc3ccccc3)C2)c1.O=S(=O)(Cl)c1cccc(OC(F)(F)F)c1>>O=S(=O)(Nc1cccc([C@@H]2CCN(Cc3ccccc3)C2)c1)c1cccc(OC(F)(F)F)c1",
        "output": "68"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CO.COC(=O)c1ccc(NCCCN(C)CCc2ccccn2)c([N+](=O)[O-])c1.[Pd]>>COC(=O)c1ccc(NCCCN(C)CCc2ccccn2)c(N)c1",
        "output": "481"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCON.C[C@@H](O[C@H]1CCN(C(=O)[C@@H]2CC[C@@H](C(=O)O)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1>>CCONC(=O)[C@@H]1CC[C@@H](C(=O)N2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1",
        "output": "480"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1ccc(C2COCCO2)c2sc(N)nc12.Cl.F[P-](F)(F)(F)(F)F.O=C(O)Cc1ccccn1>>COc1ccc(C2COCCO2)c2sc(NC(=O)Cc3ccccn3)nc12",
        "output": "681"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COCSc1ccc(CC(=O)OC)cc1.O.[Li+].[OH-]>>COCSc1ccc(CC(=O)O)cc1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "B.C1CCOC1.CSC.Cl.O=C(O)c1cc(I)ccc1O>>OCc1cc(I)ccc1O",
        "output": "72"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(=O)c1ccc(-c2ccccc2)n1Cc1ccc(F)cc1.CCOC(=O)C(=O)OCC.CCOC(C)=O.CC[O-].[Na+]>>CCOC(=O)C(=O)CC(=O)c1ccc(-c2ccccc2)n1Cc1ccc(F)cc1",
        "output": "526"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClCCl.O.O=S(=O)(Cl)CCN1CCOCC1.OCCOc1ccn(-c2ccc(Cl)c(Cl)c2)n1>>O=S(=O)(CCN1CCOCC1)OCCOc1ccn(-c2ccc(Cl)c(Cl)c2)n1",
        "output": "0"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)c1c(-c2ccccc2F)c2cc(Cl)ccc2[nH]c1=O.O.[Al+3].[H-].[H-].[H-].[H-].[H-].[Li+]>>O=c1[nH]c2ccc(Cl)cc2c(-c2ccccc2F)c1CO",
        "output": "383"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCO1.CCOC(=O)c1cn(CCCCCNC(=O)OC(C)(C)C)c2ccccc12.Cl.ClCCl>>CCOC(=O)c1cn(CCCCCN)c2ccccc12",
        "output": "538"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1cnc2[nH]c(-c3ccc(OCCCN(C)C)cc3)c(C3CCCNC3)c2c1.O=C1c2ccccc2C(=O)N1CCS(=O)(=O)Cl>>Cc1cnc2[nH]c(-c3ccc(OCCCN(C)C)cc3)c(C3CCCN(S(=O)(=O)CCN4C(=O)c5ccccc5C4=O)C3)c2c1",
        "output": "584"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COc1ccc(C(=O)CBr)cc1.Nc1ccccn1.O.O=C([O-])O.[Na+]>>COc1ccc(-c2cn3ccccc3n2)cc1",
        "output": "508"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.C=CC(=O)Cl.CCN(C(C)C)C(C)C.CN1CCN(c2ccc(Nc3nc(Oc4cccc(N)c4)c(C(C)(C)O)nc3C(N)=O)cc2)CC1.ClC(Cl)Cl.O=C([O-])O.[Na+].[Na+].[OH-]>>C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)c(C(N)=O)nc2C(C)(C)O)c1",
        "output": "10"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(CC(=O)O)c1nc2c3cccnc3ccc2n1C.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(CC(=O)Cl)c1nc2c3cccnc3ccc2n1C",
        "output": "56"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCCBr.CCOc1cc(Br)ccc1O.CN(C)C=O.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>CCOCCOc1ccc(Br)cc1OCC",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCI.CN(C)C=O.Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCNCC2)cc1.O=C([O-])[O-].[K+].[K+]>>CCN1CCC(Oc2ccc(-n3c(C)nc4ccccc4c3=O)cc2)CC1",
        "output": "184"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CCN(CC)CC.CCOC(=O)CCN.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O.O=C(O)CC1CCC(c2ccc(-c3cnc(Nc4cccc(Cl)c4)o3)cc2)CC1>>CCOC(=O)CCNC(=O)CC1CCC(c2ccc(-c3cnc(Nc4cccc(Cl)c4)o3)cc2)CC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCCO.CCCc1nc2c(N)nc3cc(Br)ccc3c2n1NC(C)C.CS(=O)(=O)Nc1cccc(B(O)O)c1.O.O=C([O-])[O-].[Na+].[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCc1nc2c(N)nc3cc(-c4cccc(NS(C)(=O)=O)c4)ccc3c2n1NC(C)C",
        "output": "909"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)c1nc(N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)ccc1CCCI.CCOC(=O)c1nc(N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)sc1CCCI.CN1CCC(Nc2ccc(O)cc2)CC1.O=C(O)C(F)(F)F>>CN1CCC(Nc2ccc(OCCCc3ccc(N4CCc5cccc(C(=O)Nc6nc7ccccc7s6)c5C4)nc3C(=O)OC(C)(C)C)cc2)CC1",
        "output": "198"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc(OC)c2c(c1)SC1(CCCCC1)CC2=O.Cl.Cl.c1ccncc1>>O=C1CC2(CCCCC2)Sc2cc(O)cc(O)c21",
        "output": "20"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrCc1ccccc1.CN(C)C=O.COC(=O)c1ccc(Cc2ccccc2O)cc1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc(Cc2ccccc2OCc2ccccc2)cc1",
        "output": "127"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cc1cc(N(C)CC(=O)O)ccc1Oc1ccc([N+](=O)[O-])cn1.Cl.O.O.On1nnc2ccccc21.c1cc2c(cc1CN1CCNCC1)OCO2>>Cc1cc(N(C)CC(=O)N2CCN(Cc3ccc4c(c3)OCO4)CC2)ccc1Oc1ccc([N+](=O)[O-])cn1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COc1ccc([C@]23CC[C@H](N)C[C@H]2N(C)CC3)cc1OC.O=C=Nc1ccc(Cl)c(C(F)(F)F)c1>>COc1ccc([C@]23CC[C@H](NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)C[C@H]2N(C)CC3)cc1OC",
        "output": "35"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)/C=C/c1cc[nH]c1.O=S(=O)(Cl)c1cccc(-c2ccccc2)c1>>CC(C)(C)OC(=O)/C=C/c1ccn(S(=O)(=O)c2cccc(-c3ccccc3)c2)c1",
        "output": "648"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COc1ccc(Cn2nc(N3CCCN(C(=O)OC(C)(C)C)CC3)c3c(Oc4ccc(NC(=O)c5ccnn(-c6ccc(F)cc6)c5=O)cc4F)ccnc32)cc1.ClCCl.O=C(O)C(F)(F)F>>COc1ccc(Cn2nc(N3CCCNCC3)c3c(Oc4ccc(NC(=O)c5ccnn(-c6ccc(F)cc6)c5=O)cc4F)ccnc32)cc1",
        "output": "575"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.CN1CCc2ccc(N3C[C@H](N)CC3=O)cc2CC1.F[B-](F)(F)F.O=C(O)C(F)(F)F.O=C(O)c1ccc(Br)s1>>CN1CCc2ccc(N3C[C@H](NC(=O)c4ccc(Br)s4)CC3=O)cc2CC1",
        "output": "736"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)c1cc2ccc(C(F)C(=O)O)cc2s1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.[NH4+].[OH-]>>CCOC(=O)c1cc2ccc(C(F)C(N)=O)cc2s1",
        "output": "313"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(=O)c1c[nH]c(C(=O)c2ccccc2)c1C.CO.[Na+].[OH-]>>Cc1c(C(=O)O)c[nH]c1C(=O)c1ccccc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)c1nn(-c2ccc(C(F)(F)F)cn2)cc1CCCO.CCCCP(CCCC)CCCC.COC(=O)Cc1c(O)cccc1OC.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>COc1cccc(OCCCc2cn(-c3ccc(C(F)(F)F)cn3)nc2C(C)C)c1CC(=O)O",
        "output": "928"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCCCCCCCCCBr.CCO.O.O=C(O)c1ccc(O)c(Cl)c1.[Na+].[OH-]>>CCCCCCCCCCCCOc1ccc(C(=O)O)cc1Cl",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCN(CCCCCC)c1ccc([N+](=O)[O-])cc1C#N.CO.[Pd]>>CCCCCCN(CCCCCC)c1ccc(N)cc1C#N",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COc1cc(Nc2nc3c(s2)CNCC3)ccc1-n1cnc(C)c1.Cl.Cl.Cl.O=S(=O)(Cl)Cc1ccccc1>>COc1cc(Nc2nc3c(s2)CN(S(=O)(=O)Cc2ccccc2)CC3)ccc1-n1cnc(C)c1",
        "output": "584"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)NC1(CN)CCN(C(=O)OC(C)(C)C)CC1.CCN(CC)CC.ClCCl.O.O=C(Cl)c1ccc(Cl)cc1.[Na+].[OH-]>>CC(C)(C)OC(=O)NC1(CNC(=O)c2ccc(Cl)cc2)CCN(C(=O)OC(C)(C)C)CC1",
        "output": "271"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)c1ccc(/C=C/c2ccccc2O)cc1NC(=O)c1ccccc1.O=C(O)C(F)(F)F>>O=C(Nc1cc(/C=C/c2ccccc2O)ccc1C(=O)O)c1ccccc1",
        "output": "752"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "O=C(O)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1.c1cc2occc2c(N2CCNCC2)n1>>O=C(c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1)N1CCN(c2nccc3occc23)CC1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCOc1c(C2CCNCC2)ccc2c1CC[C@H](C)N2C(C)=O.CCN(CC)CC.COC(=O)Cl.ClCCl>>CCCOc1c(C2CCN(C(=O)OC)CC2)ccc2c1CC[C@H](C)N2C(C)=O",
        "output": "219"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1cc2c(NC(=O)NC3CCN(Cc4ccccc4)C3)cccc2cn1.ClCCl.O=C[O-].[NH4+].[Pd]>>Cc1cc2c(NC(=O)NC3CCNC3)cccc2cn1",
        "output": "84"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cl.Cl.N[C@H]1CN2CCC1CC2.O.O=C(Cl)OCc1ccccc1.[Cl-].[H-].[Na+].[Na+]>>O=C(N[C@H]1CN2CCC1CC2)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)CCCNc1ccc(N)cc1F.Cl.Cn1cccc1C(=O)Nc1cccc(-c2nc(N)sc2-c2ccnc(Cl)n2)c1>>CN(C)CCCNc1ccc(Nc2nccc(-c3sc(N)nc3-c3cccc(NC(=O)c4cccn4C)c3)n2)cc1F",
        "output": "808"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "O=C(O)COc1ncc(C(=O)Nc2ccc(F)cc2)cn1.OC1CCCCCC1>>O=C(COc1ncc(C(=O)Nc2ccc(F)cc2)cn1)OC1CCCCCC1",
        "output": "17"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCN1.Cl.Cl.ClCCOc1ccccc1C=Cc1ccccn1.Nc1c(F)c(N)c(F)c(F)c1F>>C(=Cc1ccccc1OCCN1CCOCC1)c1ccccn1",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)Oc1cc(C(=O)O)cc([N+](=O)[O-])c1OC(C)=O.Cc1cccc(C)n1.ClCCl.NCc1ccccc1>>CC(=O)Oc1cc(C(=O)NCc2ccccc2)cc([N+](=O)[O-])c1OC(C)=O",
        "output": "753"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=P(Cl)(Cl)Cl.Oc1c2c(nc3cc(Cl)cc(Cl)c13)CCCC2>>Clc1cc(Cl)c2c(Cl)c3c(nc2c1)CCCC3",
        "output": "177"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCC2=NCCCN2CC1.CC(C)(C)OC(=O)N1CCNCC1.Clc1nccc2ccccc12.O>>CC(C)(C)OC(=O)N1CCN(c2nccc3ccccc23)CC1",
        "output": "220"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(C(C)C)C(C)C.O=C(Cl)Oc1ccc([N+](=O)[O-])cc1.O=c1ccc(N2CCC(O)CC2)n[nH]1.c1ccncc1>>O=C(Oc1ccc([N+](=O)[O-])cc1)OC1CCN(c2ccc(=O)[nH]n2)CC1",
        "output": "662"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCN1.CCN(CC)CC.CCO.OB(O)c1cnc(Cl)nc1>>OB(O)c1cnc(N2CCOCC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC.COC(=O)c1ccc(CC(=O)N2CCc3c(n(Cc4cccc(F)c4)c4ncccc34)C2)cc1O.O.[Na+].[OH-]>>O=C(O)c1ccc(CC(=O)N2CCc3c(n(Cc4cccc(F)c4)c4ncccc34)C2)cc1O",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.O=[N+]([O-])c1ccccc1Nc1cccc(C(c2cccc(Nc3ccccc3[N+](=O)[O-])c2)(C(F)(F)F)C(F)(F)F)c1.[C].[H][H].[Pd]>>Nc1ccccc1Nc1cccc(C(c2cccc(Nc3ccccc3N)c2)(C(F)(F)F)C(F)(F)F)c1",
        "output": "204"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CCc1cc(O)c(F)c(C(O)c2nc(Br)c[nH]2)c1.CI.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCc1cc(OC)c(F)c(C(O)c2nc(Br)c[nH]2)c1",
        "output": "62"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)=O.COC(=O)C(NC(=O)c1ccc(Nc2nc(NCc3ccc(OCCCCCCN)cc3)nc(OCC(F)(F)F)n2)cc1)C1CCCNC1.Cl.O.O=C([O-])[O-].[K+].[K+]>>NCCCCCCOc1ccc(CNc2nc(Nc3ccc(C(=O)NC(C(=O)O)C4CCCNC4)cc3)nc(OCC(F)(F)F)n2)cc1",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccccc1.O=C(Cl)c1ccccc1>>COc1ccc(C(=O)c2ccccc2)cc1",
        "output": "61"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CI.CN(C)C=O.O=C(O)CCc1c[nH]c2ccccc12.O=C([O-])[O-].[K+].[K+]>>COC(=O)CCc1c[nH]c2ccccc12",
        "output": "415"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "O=C(O)CC1CCCCCC1.O=S(Cl)Cl>>O=C(Cl)CC1CCCCCC1",
        "output": "53"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N1CCNCC1.COC(=O)[C@H]1[C@H](c2ccc(Br)cc2)[C@H]1c1ccccc1>>COC(=O)[C@H]1[C@H](c2ccc(N3CCN(C(C)C)CC3)cc2)[C@H]1c1ccccc1",
        "output": "294"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1.ClCCl.Fc1c(OCc2ccccc2)ccc2[nH]ccc12>>CC(C)(C)OC(=O)n1ccc2c(F)c(OCc3ccccc3)ccc21",
        "output": "748"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)c1cc(C(=O)O)[nH]n1.CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.Cl.N#Cc1ccc(-c2cc(CCN)on2)cc1Cl.O.On1nnc2ccccc21>>CC(=O)c1cc(C(=O)NCCc2cc(-c3ccc(C#N)c(Cl)c3)no2)[nH]n1",
        "output": "816"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.COCCS(=O)(=O)N1CCN(c2ccc(N3CCN(C(=O)OC(C)(C)C)c4ccccc43)cc2)CC1.Cl.ClCCl.O=C([O-])O.[Na+]>>COCCS(=O)(=O)N1CCN(c2ccc(N3CCNc4ccccc43)cc2)CC1",
        "output": "830"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=CC(=O)Cl.CCN(CCCCCCO)c1ccc(/N=N/c2ccc([N+](=O)[O-])cc2C#N)cc1.CCOC(C)=O.ClCCl>>C=CC(=O)OCCCCCCN(CC)c1ccc(/N=N/c2ccc([N+](=O)[O-])cc2C#N)cc1",
        "output": "320"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCN(CC)CC.Nc1nc(-c2c[nH]c3ncccc23)cs1.O=C(O)Cc1cccc([N+](=O)[O-])c1>>O=C(Cc1cccc([N+](=O)[O-])c1)Nc1nc(-c2c[nH]c3ncccc23)cs1",
        "output": "681"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CCN(C(C)C)C(C)C.CCOC(=O)c1cc(C#N)c(Cl)nc1C.CCOC(C)=O.CN(C)C=O.O=C(O)CC1CCCNC1>>CCOC(=O)c1cc(C#N)c(N2CCCC(CC(=O)O)C2)nc1C",
        "output": "220"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)CC(O)c1cccc(C(=O)C(C(=O)c2cccc(F)c2)=C2Nc3ccccc3N2)c1.CCO.[BH4-].[Na+]>>CC(O)CC(O)c1cccc(C(=O)C(C(=O)c2cccc(F)c2)=C2Nc3ccccc3N2)c1",
        "output": "91"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.O.O=C1CCC(=O)c2ccccc2N1.[Cl-].[Na+]>>O=C1CCC(=S)Nc2ccccc21",
        "output": "695"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CNC1CCOCC1.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Br)nc1.[K+].[K+]>>CN(c1ccc([N+](=O)[O-])cn1)C1CCOCC1",
        "output": "647"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C(=O)Nc1ccc(F)cc1)c1ccc(OCc2ccccc2)cc1F.CO.[C].[Pd]>>CN(C(=O)Nc1ccc(F)cc1)c1ccc(O)cc1F",
        "output": "698"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)O.COc1cccc(-c2ccc(-n3c(Cl)cc4[nH]c(=O)n(CC(=O)O)c(=O)c43)cc2)c1O.Cl>>COc1cccc(-c2ccc(-n3c(Cl)cc4[nH]c(=O)n(CC(=O)OC(C)C)c(=O)c43)cc2)c1O",
        "output": "17"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCCCCCCc1cnc(-c2ccc(O)cc2)nc1.CN(C)C=O.ClCCCBr.F[C@@H](COCCCCl)COCC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)C(F)(F)F.OC[C@H](F)COCC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)C(F)(F)F>>CCCCCCCc1cnc(-c2ccc(OCCCOC[C@H](F)COCC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc2)nc1",
        "output": "74"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(C)=O.CO.O=C(NC1CCc2c(-c3ccccc3)[nH]c3cccc1c23)c1ccccc1[N+](=O)[O-].[C].[Pd]>>Nc1ccccc1C(=O)NC1CCc2c(-c3ccccc3)[nH]c3cccc1c23",
        "output": "486"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](N)CC1.Cc1c(C(=O)O)c2nccc(-c3ccc(F)cc3OCC3CC3)c2n1COCC[Si](C)(C)C>>Cc1c(C(=O)N[C@@H]2CC[C@@H](NC(=O)OC(C)(C)C)CC2)c2nccc(-c3ccc(F)cc3OCC3CC3)c2n1COCC[Si](C)(C)C",
        "output": "737"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(C(=O)O)c(=O)n1-c1cccc(C(F)(F)F)c1.ClC(Cl)(Cl)Cl.ClC(Cl)Cl.O=C1CCC(=O)N1Br>>O=C(O)c1ccc(CBr)n(-c2cccc(C(F)(F)F)c2)c1=O",
        "output": "590"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.C=O.CC(=O)O.CCOC(C)=O.CNC(=O)Nc1ccc(Oc2ccnc3cc(OCC4CCNCC4)c(C#N)cc23)cc1Cl.CO.O.O=C([O-])O.[BH3-]C#N.[Na+].[Na+]>>CNC(=O)Nc1ccc(Oc2ccnc3cc(OCC4CCN(C)CC4)c(C#N)cc23)cc1Cl",
        "output": "217"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.O.[N-]=[N+]=NC1CCCc2ccc(Cl)nc21.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NC1CCCc2ccc(Cl)nc21",
        "output": "89"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1.[Na+].[OH-]>>CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cl.ClCCl.O.O=C(O)C=Cc1cc([N+](=O)[O-])ccc1Cl.O=C([O-])O.[Na+]>>COC(=O)C=Cc1cc([N+](=O)[O-])ccc1Cl",
        "output": "174"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCC(CCC)(C(=O)OC)c1ccccc1.CCCCC(CCCC)(C(=O)OC)c1ccccc1>>CCCCC(CCCC)(C(=O)O)c1ccccc1",
        "output": "203"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCC(=O)Cl.CCOC(C)=O.Nc1cc([N+](=O)[O-])ccc1O.c1ccncc1>>CCCC(=O)Nc1cc([N+](=O)[O-])ccc1O",
        "output": "9"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.C[C@@H]1CNCCN1C(=O)OC(C)(C)C.Clc1ccc(Cl)nn1>>C[C@@H]1CN(c2ccc(Cl)nn2)CCN1C(=O)OC(C)(C)C",
        "output": "406"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(C)=O.O.O=Cc1ccc(OCCCBr)cc1.[N-]=[N+]=[N-].[Na+]>>[N-]=[N+]=NCCCOc1ccc(C=O)cc1",
        "output": "622"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.C[O-].Cc1ncc(-c2ccc(Br)cc2F)o1.O.[Na+]>>COc1cc(Br)ccc1-c1cnc(C)o1",
        "output": "485"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)Cl.CN(C)C=O.Cc1nccn1-c1nc(-c2ccc(Cl)cc2)c(CCC(=O)O)o1.Cl.NCCCl.O>>Cc1nccn1-c1nc(-c2ccc(Cl)cc2)c(CCC(=O)NCCCl)o1",
        "output": "230"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)C[AlH]CC(C)C.CCOC(=O)Cc1c([N+](=O)[O-])cc(OCc2ccccc2)c2ccccc12.Cl.N#N>>O=[N+]([O-])c1cc(OCc2ccccc2)c2ccccc2c1CCO",
        "output": "225"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCN(CC)CC.CN(C)c1ccncc1.ClCCl.N[C@@H]1c2ccccc2C[C@H]1O.O>>CC(C)(C)[Si](C)(C)O[C@@H]1Cc2ccccc2[C@H]1N",
        "output": "193"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.C[C@@H](N)c1cccc(O)c1.ClCCl>>C[C@@H](NC(=O)OC(C)(C)C)c1cccc(O)c1",
        "output": "686"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClP(Cl)(Cl)(Cl)Cl.O=P(Cl)(Cl)Cl.O=[N+]([O-])c1cnc(O)c(F)c1>>O=[N+]([O-])c1cnc(Cl)c(F)c1",
        "output": "41"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.ClCC1CO1.O.Oc1ccc(-c2ccc(-c3nc(C(F)(F)F)cn3Cc3ccccc3)o2)cc1.[Na+].[OH-]>>FC(F)(F)c1cn(Cc2ccccc2)c(-c2ccc(-c3ccc(OCC4CO4)cc3)o2)n1",
        "output": "15"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.C[C@@H]1CN[C@@H](CO)CN1C(=O)OC(C)(C)C.ClCCCl.O=Cc1ccccc1.[Na+]>>C[C@@H]1CN(Cc2ccccc2)[C@@H](CO)CN1C(=O)OC(C)(C)C",
        "output": "567"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)O.CCN(C(C)C)C(C)C.COc1ccc2c(OCC(C)(C)n3cc(N)ccc3=O)ccnc2c1.ClCCl.O=C(Cl)c1ccccc1>>COc1ccc2c(OCC(C)(C)n3cc(NC(=O)c4ccccc4)ccc3=O)ccnc2c1",
        "output": "501"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(=O)Nc1ccc(-c2cc(=O)c3c(NCCCOS(C)(=O)=O)c(F)cc(F)c3o2)cc1F.CCNCC.CN(C)C=O.O.O=C([O-])[O-].[K+].[K+]>>CCN(CC)CCCNc1c(F)cc(F)c2oc(-c3ccc(NC(=O)C(C)(C)C)c(F)c3)cc(=O)c12",
        "output": "496"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1N.CCN(CC)CC.CN(C)C=O.COC(=O)c1c(C#N)cc(Cl)nc1Nc1cccc(S(C)(=O)=O)c1.O=C([O-])O.[Na+]>>COC(=O)c1c(C#N)cc(N[C@@H]2CCCC[C@@H]2NC(=O)OC(C)(C)C)nc1Nc1cccc(S(C)(=O)=O)c1",
        "output": "70"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1cccc(-c2[nH]c(C(C)C)nc2-c2cccc(Br)c2)n1.OB(O)c1ccccc1F>>Cc1cccc(-c2[nH]c(C(C)C)nc2-c2cccc(-c3ccccc3F)c2)n1",
        "output": "837"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=O.CC#N.OCC1CCNCC1.[BH3-]C#N.[Na+]>>CN1CCC(CO)CC1",
        "output": "217"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Cl.OCCc1ccc(Br)cc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCc1ccc(Br)cc1",
        "output": "193"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Cl.CCN(CC)CC.CCOC(=O)c1sc(SC)c(C#N)c1-c1ccc(N)cc1.ClCCl.[Cl-].[NH4+]>>CCOC(=O)c1sc(SC)c(C#N)c1-c1ccc(NC(C)=O)cc1",
        "output": "9"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CN(CCC1CCN(C(=O)OCc2ccccc2)CC1)C(=O)OC(C)(C)C.O.O=C[O-].[NH4+].[OH-].[OH-].[Pd+2].[Pd]>>CN(CCC1CCNCC1)C(=O)OC(C)(C)C",
        "output": "428"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=[N+]=[N-].CO.COc1cc(C(=O)O)c(N)c([N+](=O)[O-])c1>>COC(=O)c1cc(OC)cc([N+](=O)[O-])c1N",
        "output": "195"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCNC1.CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1.CC(C)=O.O>>CC(=O)Nc1ccc(S(=O)(=O)N2CCCC2)cc1",
        "output": "99"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCc1cnccc1CBr.CN(C)C=O.Cc1cc(O)nc(S)n1.O=C([O-])[O-].[K+].[K+]>>CCc1cnccc1CSc1nc(C)cc(O)n1",
        "output": "699"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)[C@@H](Cc1ccccc1OC)Oc1ncnc2sc(C(=O)O)c(-c3ccc(OCCN4CCN(C)CC4)c(Cl)c3C)c12.CNC.ClCCl.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CCOC(=O)[C@@H](Cc1ccccc1OC)Oc1ncnc2sc(C(=O)N(C)C)c(-c3ccc(OCCN4CCN(C)CC4)c(Cl)c3C)c12",
        "output": "857"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC#N.CN(C)c1ccncc1.Nc1ccc(C(=O)O)cc1.Oc1ccccc1>>Nc1ccc(C(=O)Oc2ccccc2)cc1",
        "output": "355"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(C(C)C)C(C)C.COC(=O)C1CCNC(CCc2ccc(F)cc2)C1.COC(=O)Cl.Cl.ClCCl>>COC(=O)C1CCN(C(=O)OC)C(CCc2ccc(F)cc2)C1",
        "output": "219"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)CCCCBr.CN(C)C=O.O=C([O-])[O-].Oc1ccc(Br)cc1.[Cs+].[Cs+]>>CCOC(=O)CCCCOc1ccc(Br)cc1",
        "output": "75"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.O=[N+]([O-])c1ccc(CCC(O)c2ccc(Cl)c(Cl)c2)cc1O.[Ni]>>Nc1ccc(CCC(O)c2ccc(Cl)c(Cl)c2)cc1O",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)NC1CCNCC1.Cc1ccc([N+](=O)[O-])c(F)c1>>Cc1ccc([N+](=O)[O-])c(N2CCC(NC(=O)OC(C)(C)C)CC2)c1",
        "output": "26"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(C)=O.CCOc1cc(-c2nncn2C)ccc1[N+](=O)[O-]>>CCOc1cc(-c2nncn2C)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)(CC(=O)OCc4ccccc4)C(OC)C3)C(C)C(O[Si](C)(C)C(C)(C)C)CC1=O)C(C)CC2OC>>CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)(CC(=O)OCc4ccccc4)C(OC)C3)C(C)C(O)CC1=O)C(C)CC2OC",
        "output": "708"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCC(CC)CO.Cc1ccccc1.O.O=C(O)c1ccccc1O.O=S(=O)(O)O>>CCCCC(CC)COC(=O)c1ccccc1O",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(Oc1cccnc1[N+](=O)[O-])c1c(Cl)ccc(F)c1Cl.CCO.Cl.[Fe]>>CC(Oc1cccnc1N)c1c(Cl)ccc(F)c1Cl",
        "output": "457"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)O.CCN(CC)CC.ClCCCl.ClCCl.NC(=O)[C@@H](N)CSC(c1ccccc1)(c1ccccc1)c1ccccc1.On1nnc2ccccc21>>CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)C(N)=O",
        "output": "131"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC(O)C1.O.O=[N+]([O-])c1ccccc1F.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCC(Oc2ccccc2[N+](=O)[O-])C1",
        "output": "485"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.CS(=O)(=O)c1ccc(-n2nc(-c3ccc4c(c3)CCN(C(=O)C(F)(F)F)CC4)ccc2=O)cc1.ClCCl.O=C([O-])[O-].[K+].[K+]>>CS(=O)(=O)c1ccc(-n2nc(-c3ccc4c(c3)CCNCC4)ccc2=O)cc1",
        "output": "703"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.O=C(O)CNc1cc(Cl)cc(Cl)c1.On1nnc2ccccc21.c1nc(N[C@H]2CCCNC2)c2cn[nH]c2n1>>O=C(CNc1cc(Cl)cc(Cl)c1)N1CCC[C@H](Nc2ncnc3[nH]ncc23)C1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCC(O)CCN(CC)CC.CCN(CC)CC.COc1cc2nccc(Oc3ccc(N)cc3)c2cc1OC.Cc1ccccc1.ClCCl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.O=C([O-])O.[Na+]>>CCCC(CCN(CC)CC)OC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1",
        "output": "960"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.Cl.ClCCN1CCOCC1.O=C([O-])[O-].O=C1c2ccc(Cl)cc2CCc2c(O)cccc21.[K+].[K+]>>O=C1c2ccc(Cl)cc2CCc2c(OCCN3CCOCC3)cccc21",
        "output": "74"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(C)=O.COC(=O)c1c(-c2ccc(Cl)cc2Cl)nc2c3cc(NC(C)=O)ncc3ccn12.Cl.[Na+].[OH-]>>CC(=O)Nc1cc2c(ccn3c(C(=O)O)c(-c4ccc(Cl)cc4Cl)nc23)cn1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.CC(C)(C)OC(=O)[C@H](CN)NC(=O)OCc1ccccc1.CN(C)C=O.COC(=O)COc1ccc(C(=O)O)cc1.On1nnc2ccccc21>>COC(=O)COc1ccc(C(=O)NC[C@H](NC(=O)OCc2ccccc2)C(=O)OC(C)(C)C)cc1",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1cc(F)c(C=O)c(F)c1.O.O=[Ag].[Na+].[OH-]>>Cc1cc(F)c(C(=O)O)c(F)c1",
        "output": "384"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.COC(=O)c1cc(Oc2cc(F)ccc2NS(=O)(=O)c2ccc(C)cc2)ccc1NS(=O)(=O)c1ccc(C)cc1.[Li+].[OH-]>>Cc1ccc(S(=O)(=O)Nc2ccc(F)cc2Oc2ccc(NS(=O)(=O)c3ccc(C)cc3)c(C(=O)O)c2)cc1",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CSc1ccc(C(CC2CCCC2)C(=O)O)cc1.ClCCl.Nc1nccs1.O=C1CCC(=O)N1Br.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CSc1ccc(C(CC2CCCC2)C(=O)Nc2nccs2)cc1",
        "output": "681"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.COc1cc(C(C)=O)ccc1NS(=O)(=O)C(F)(F)F.ClC(Cl)Cl.O=S([O-])([O-])=S.[Na+].[Na+]>>COc1cc(C(=O)CBr)ccc1NS(=O)(=O)C(F)(F)F",
        "output": "173"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCCc1cccc(COCCOCc2ccccc2)c1.CC1(C)OCc2cc([C@@H](O)CN)ccc2O1.CN(C)C=O>>CC1(C)OCc2cc([C@@H](O)CNCCc3cccc(COCCOCc4ccccc4)c3)ccc2O1",
        "output": "147"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.Cc1[nH]c(=O)[nH]c1C(=O)c1ccc(F)cc1.c1ccc2[nH]cnc2c1>>Cc1[nH]c(=O)[nH]c1C(=O)c1ccc(-n2cnc3ccccc32)cc1",
        "output": "721"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Brc1cncc(N2CC3CC4CC2CN(C4)C3)c1.OB(O)c1ccc(C(F)(F)F)cc1>>FC(F)(F)c1ccc(-c2cncc(N3CC4CC5CC3CN(C5)C4)c2)cc1",
        "output": "833"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)C(C)(C)Sc1ccncc1.CO.O.[Na+].[OH-]>>CC(C)(Sc1ccncc1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)Oc1ccc(COc2ccc3c(c2)cc2n3CCC2CC(=O)OC(C)(C)C)cc1C(F)(F)F.Cl.[Li+].[OH-]>>CC(C)Oc1ccc(COc2ccc3c(c2)cc2n3CCC2CC(=O)O)cc1C(F)(F)F",
        "output": "278"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)O.CCNCC.CCOC(=O)c1ccc(C(=O)CCC(=O)c2ccccc2)cc1.Cl.O.O=C(CBr)c1ccccc1.O=S(=O)(O)O.[Cl-].[Cl-].[K+].[OH-].[Zn+2].c1ccccc1>>O=C(O)c1ccc(C(=O)CCC(=O)c2ccccc2)cc1",
        "output": "5"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "B.C1CCOC1.CO.Cl.O=C1COc2ccc(Br)cc2N1.[Na+].[OH-]>>Brc1ccc2c(c1)NCCO2",
        "output": "363"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COC(=O)c1cc(F)cc2c1cnn2C(C)C.[Na+].[OH-]>>CC(C)n1ncc2c(C(=O)O)cc(F)cc21",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCC(O)CCOS(=O)(=O)c1ccc(C)cc1.CCOCC.CN(C)C=O.COC(=O)CCc1ccc(O)cc1C.Cl.O=C([O-])[O-].[Cs+].[Cs+]>>CCC(O)CCOc1ccc(CCC(=O)OC)c(C)c1",
        "output": "438"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc(C2CC2)ccc1B1OC(C)(C)C(C)(C)O1.O=S(=O)(Nc1ncns1)N1CCc2c(ccnc2Cl)C1>>COc1cc(C2CC2)ccc1-c1nccc2c1CCN(S(=O)(=O)Nc1ncns1)C2",
        "output": "955"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCO.CCN(CC)CC.Cl.I[Cu]I.O=S(=O)(Nc1ccccc1)c1cccc(Br)c1.c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1.c1ccccc1>>O=S(=O)(Nc1ccccc1)c1cccc(C#CCO)c1",
        "output": "659"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(NCCc2ccc(F)cc2)cc1C.O=C(O)Cc1nc2ccccc2[nH]1>>Cc1ccc(N(CCc2ccc(F)cc2)C(=O)Cc2nc3ccccc3[nH]2)cc1C",
        "output": "315"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NC1CCC(Nc2ncc3c(-c4ccnc(NCc5ccccc5)n4)n[nH]c3n2)CC1.CO.Cl>>NC1CCC(Nc2ncc3c(-c4ccnc(NCc5ccccc5)n4)n[nH]c3n2)CC1",
        "output": "538"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(CO[Si](C)(C)C(C)(C)C)Oc1ccc(B(O)O)cc1.CCCCc1nc(C2CC2)c(Br)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.ClCCl.Cl[Pd]Cl.O=C([O-])[O-].[Cs+].[Cs+].[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCCCc1nc(C2CC2)c(-c2ccc(OC(C)(C)CO[Si](C)(C)C(C)(C)C)cc2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1",
        "output": "871"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1cc2c(Cl)ncnc2cc1OCc1ccccc1.Cl.Oc1ccc(Cl)cc1F.c1ccncc1>>COc1cc2c(Oc3ccc(Cl)cc3F)ncnc2cc1OCc1ccccc1",
        "output": "668"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COc1ccc2c(c1)N(CCN1CCC(N)CC1)C(=O)CS2.O=Cc1cc2c(cn1)OCCO2.[BH3-]C#N.[Na+]>>COc1ccc2c(c1)N(CCN1CCC(NCc3cc4c(cn3)OCCO4)CC1)C(=O)CS2",
        "output": "775"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#CCCCC.C1CCNCC1.O=Cc1cccc(Br)c1.[Cu]I.[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCCC#Cc1cccc(C=O)c1",
        "output": "659"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.NCc1ccccc1.O.O=Cc1ccccc1.OP(O)O.[Na+].[OH-]>>c1ccc(CNCc2ccccc2)cc1",
        "output": "683"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1ccccc1-c1ccc(O)cc1.ClCCCBr.O=C([O-])[O-].[K+].[K+]>>Cc1ccccc1-c1ccc(OCCCCl)cc1",
        "output": "75"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].CCO.Cl.O=C1CCCN1C1CCNCC1.O=CC1(c2ccc(OCCCN3CCCC3)cc2)CCOCC1.[Ti+4]>>O=C1CCCN1C1CCN(CC2(c3ccc(OCCCN4CCCC4)cc3)CCOCC2)CC1",
        "output": "484"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)C(=O)Nc1cccc(C2CCN(CCCN)CC2)c1.O=C(Cl)Cc1ccc(F)cc1>>CC(C)C(=O)Nc1cccc(C2CCN(CCCNC(=O)Cc3ccc(F)cc3)CC2)c1",
        "output": "45"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN1CCCC1=O.NC(=O)c1c(N)n(C2CCCC2)c2nc(Cl)ncc2c1=O.Nc1ccc(N2CCOCC2)cc1.O.O=C([O-])O.[Na+]>>NC(=O)c1c(N)n(C2CCCC2)c2nc(Nc3ccc(N4CCOCC4)cc3)ncc2c1=O",
        "output": "808"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCC1(c2cccc(OCc3ccccc3)c2)CCCCN(CCO)C1=O.CI.CN(C)C=O.[H-].[Na+]>>CCC1(c2cccc(OCc3ccccc3)c2)CCCCN(CCOC)C1=O",
        "output": "140"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.CCOC(C)=O.C[C@H](N)c1ncc(F)cn1.Cl.O=[N+]([O-])c1cnc(Cl)nc1Nc1cc(C2CC2)[nH]n1>>C[C@H](Nc1ncc([N+](=O)[O-])c(Nc2cc(C3CC3)[nH]n2)n1)c1ncc(F)cn1",
        "output": "544"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1ccc2c(c1)CCN(c1ccccc1)C2.Cl.[Na+].[OH-]>>O=C(O)c1ccc2c(c1)CCN(c1ccccc1)C2",
        "output": "247"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C[C@@H](N)COc1cccc2ncnc(Nc3ccc(O)c(Cl)c3)c12.Cl.ClCc1cscn1>>C[C@@H](N)COc1cccc2ncnc(Nc3ccc(OCc4cscn4)c(Cl)c3)c12",
        "output": "785"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)NC1(C(=O)O)CC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.NCC(=O)c1ccc(Br)cc1>>CC(C)(C)OC(=O)NC1(C(=O)NCC(=O)c2ccc(Br)cc2)CC1",
        "output": "645"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.O.O=[N+]([O-])c1cnccc1OCc1ccccc1.[Cl-].[Fe].[NH4+]>>Nc1cnccc1OCc1ccccc1",
        "output": "269"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCO.Cc1cc(OCCCON2C(=O)c3ccccc3C2=O)cc(OS(=O)(=O)c2ccccc2C#N)c1.O.[BH4-].[Na+].[Na+].[OH-]>>Cc1cc(OCCCON)cc(OS(=O)(=O)c2ccccc2C#N)c1",
        "output": "452"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCCCC1CCCN(C[C@@H]2CCCC[C@H]2N)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(-n2ccnc2)cc1>>CCCCC1CCCN(C[C@@H]2CCCC[C@H]2NC(=O)c2ccc(-n3ccnc3)cc2)C1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Brc1cncc(Br)c1.CC(C)(C)OC(=O)N1CC[C@H]2CNC[C@H]21.CC(C)(C)[O-].CCOCC.Cc1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>CC(C)(C)OC(=O)N1CC[C@H]2CN(c3cncc(Br)c3)C[C@H]21",
        "output": "597"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC=O.COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCNCc2cccc3ccccc23)CC1.[BH3-]C#N.[Na+]>>CCN(CCCCCN1CCC(CNC(=O)c2cc(Cl)c(N)cc2OC)CC1)Cc1cccc2ccccc12",
        "output": "858"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.COc1cccc(OC)c1SC.ClCCl.O>>CSc1c(O)cccc1O",
        "output": "20"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C1CC1c1ccc(Cl)cc1.CO.C[O-].O.[Li]O.[Na+]>>O=C(O)C1CC1c1ccc(Cl)cc1",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CO.COC(=O)c1ccc(-c2ccc(Nc3nc4ccc(F)cc4s3)cc2)cc1.O.[Na+].[OH-]>>O=C(O)c1ccc(-c2ccc(Nc3nc4ccc(F)cc4s3)cc2)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCCCBr.CC#N.O=C([O-])[O-].Oc1cccc(F)c1.[Cs+].[Cs+]>>Fc1cccc(OCCCBr)c1",
        "output": "75"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1[C@H](CO)COC1(C)C.CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.Oc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CC(C)(C)OC(=O)N1[C@H](COc2ccccc2)COC1(C)C",
        "output": "550"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.Nc1cc(F)ccn1.O=C1CCC(=O)N1I>>Nc1cc(F)c(I)cn1",
        "output": "783"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCS(=O)(=O)CCCn1c(CO)cc2cc(Cl)cnc21.ClCCl.O=S(Cl)Cl>>CCS(=O)(=O)CCCn1c(CCl)cc2cc(Cl)cnc21",
        "output": "594"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(=O)c1ccn(-c2cccc(Nc3ccc(Cl)cc3)n2)n1.Cl>>O=C(O)c1ccn(-c2cccc(Nc3ccc(Cl)cc3)n2)n1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN.O=C=NCCCl>>CCNC(=O)NCCCl",
        "output": "244"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C#N)c1cccc(C(=O)O)c1.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1.On1nnc2ccccc21>>CC(C)(C#N)c1cccc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)c1",
        "output": "50"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F.CC(C)c1nc2c(c(C3CCCC3)c1C(=O)c1ccc(C(F)(F)F)cc1)[C@@H](O)CC(C)(C)C2.Cc1cccc(C)n1.Cc1ccccc1.[Cl-].[NH4+]>>CC(C)c1nc2c(c(C3CCCC3)c1C(=O)c1ccc(C(F)(F)F)cc1)[C@@H](O[Si](C)(C)C(C)(C)C)CC(C)(C)C2",
        "output": "839"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)=O.Cc1ccc(S(=O)(=O)O)cc1.N#CCC1(c2ccc(Cl)cc2)CCC2(CC1)OCCO2.O>>N#CCC1(c2ccc(Cl)cc2)CCC(=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOCC.C[Mg]Br.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=Cc1cc(F)c(OCc2ccccc2)c(F)c1OCc1ccccc1>>CC(O)c1cc(F)c(OCc2ccccc2)c(F)c1OCc1ccccc1",
        "output": "787"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(OCC)[C@H](C)N(Cc1cccc2ccccc12)C(=O)[C@@H](N)Cc1ccc(OC(C)(C)C)cc1.CN(CC(=O)O)NC(=O)NCc1ccc(Cl)cc1>>CCOC(OCC)[C@H](C)N(Cc1cccc2ccccc12)C(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)CN(C)NC(=O)NCc1ccc(Cl)cc1",
        "output": "133"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COC(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1[N+](=O)[O-].[H][H].c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1>>COC(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1N",
        "output": "268"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(=O)O.CCCC[N+](CCCC)(CCCC)CCCC.CCc1ccc(CO[Si](C)(C)C(C)(C)C)c(C(=O)OC(C)(C)C)c1OCOC.O.[F-]>>CCc1ccc(CO)c(C(=O)OC(C)(C)C)c1OCOC",
        "output": "708"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC1CCC2(CC1)OCCO2.Cl>>COC1CCC(=O)CC1",
        "output": "251"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cl.Nn1nc(-c2ccc(Cl)cc2)c2ccccc2c1=O.O=C(O)Cc1cccnc1>>O=C(Cc1cccnc1)Nn1nc(-c2ccc(Cl)cc2)c2ccccc2c1=O",
        "output": "459"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "B.C1CCOC1.CCCCCCCCCCc1ccc(C(=O)O)cc1.Cl>>CCCCCCCCCCc1ccc(CO)cc1",
        "output": "72"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COCCCBr.N[C@@H]1CCN(c2ccc(N3CCc4cc(OC[C@@H]5CCCO5)ccc4C3=O)cc2F)C1>>COCCCN[C@@H]1CCN(c2ccc(N3CCc4cc(OC[C@@H]5CCCO5)ccc4C3=O)cc2F)C1",
        "output": "147"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.O=C1CSC(=S)N1Cc1ccccc1.O=Cc1ccccc1>>O=C1C(=Cc2ccccc2)SC(=S)N1Cc1ccccc1",
        "output": "314"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cc(C(F)(F)F)ccc1-c1cc(C=O)ccc1OC.C[Mg]Br.[Cl-].[NH4+]>>COC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cc(C(F)(F)F)ccc1-c1cc(C(C)O)ccc1OC",
        "output": "787"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cc(-c2nn(C3CCN(C(=O)OCc4ccccc4)CC3)c3ncnc(N)c23)ccc1N.O=C(Cl)[C@@H]1C[C@H]1c1ccccc1.c1ccncc1>>COc1cc(-c2nn(C3CCN(C(=O)OCc4ccccc4)CC3)c3ncnc(N)c23)ccc1NC(=O)[C@@H]1C[C@H]1c1ccccc1",
        "output": "9"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Nc1cccc(-c2c(Cc3ccccc3)cnc3c(C(F)(F)F)cccc23)c1.O=Cc1ccc(F)c(F)c1>>Fc1ccc(CNc2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)cc1F",
        "output": "359"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCc1ccc2c3c1cc(C(=O)OC)n3CC(=O)CN2.[Na+].[OH-]>>CCc1ccc2c3c1cc(C(=O)O)n3CC(=O)CN2",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CCN(CC)CC.COc1ccc(CCN)cc1C.N.O.O=C(O)C1(c2cccs2)CC1.On1nnc2ccccc21>>COc1ccc(CCNC(=O)C2(c3cccs3)CC2)cc1C",
        "output": "230"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCO[C@H]1CC[C@@H](N2CCC(Nc3cc(Br)c(C(F)(F)F)cc3[N+](=O)[O-])CC2)CC1.CCO.NN.O.[Ni]>>CCCO[C@H]1CC[C@@H](N2CCC(Nc3cc(Br)c(C(F)(F)F)cc3N)CC2)CC1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.Cl.ClC(Cl)Cl.NCCc1c[nH]c2ccc(Cl)cc12.O=C(O)c1ccc(Cc2ccccc2)cc1.O=S(Cl)Cl>>O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccc(Cc2ccccc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CC2CNCC2C1.COC(=O)c1cc(C)nc(Cl)n1>>COC(=O)c1cc(C)nc(N2CC3CN(C(=O)OC(C)(C)C)CC3C2)n1",
        "output": "36"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCOCCOCCOCCO1.CN(C)C=O.COc1nccc2[nH]nc(-c3ccc(N4CCOCC4)cc3)c12.N#Cc1cc(F)c(F)c(F)c1.O=C([O-])O.[H-].[Na+].[Na+]>>COc1nccc2c1c(-c1ccc(N3CCOCC3)cc1)nn2-c1c(F)cc(C#N)cc1F",
        "output": "751"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrB(Br)Br.COc1ccc(F)cc1-c1ncc(OC[C@@H](N)Cc2ccccc2)cc1-c1ccc2[nH]nc(C)c2c1>>Cc1n[nH]c2ccc(-c3cc(OC[C@@H](N)Cc4ccccc4)cnc3-c3cc(F)ccc3O)cc12",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CCc1cc2cc(F)ccc2[nH]1.O=C1CCNCC1.O=P(O)(O)O.[Na+].[OH-]>>CCc1[nH]c2ccc(F)cc2c1C1=CCNCC1",
        "output": "607"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CS(N)(=O)=O.NS(=O)(=O)N1CCC1.O=C(O)c1cc(C2CC2)c(OCC2(C(F)(F)F)CCCCC2)cc1F.O=C(O)c1cc(C2CC2)c(OCC2C3CC4CC(C3)CC2C4)cc1F>>O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC2C3CC4CC(C3)CC2C4)cc1F",
        "output": "886"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)c1ccc(N)cc1.COc1c(Cl)ccnc1C.Oc1ccccc1.[Na+].[OH-]>>COc1c(Nc2ccc(C(C)(C)C)cc2)ccnc1C",
        "output": "115"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCOC(=O)C(=NOC1CCCCC1)c1csc(N)n1.CO.[Na+].[OH-]>>Nc1nc(C(=NOC2CCCCC2)C(=O)O)cs1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCCO.CCN(C(C)C)C(C)C.Cc1c(Cl)cccc1-c1cc(Cl)nc(N)n1.NCCc1ccc(S(N)(=O)=O)cc1>>Cc1c(Cl)cccc1-c1cc(NCCc2ccc(S(N)(=O)=O)cc2)nc(N)n1",
        "output": "166"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)Cl.Nc1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2ccccc2)cc1>>CS(=O)(=O)Nc1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2ccccc2)cc1",
        "output": "194"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOCC.N#CCS(=O)(=O)Cl.NCc1ccccc1.O>>N#CCS(=O)(=O)NCc1ccccc1",
        "output": "742"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(O)c1ccc(O)nc1.O=S(=O)(O)O.OCc1ccccc1>>O=C(OCc1ccccc1)c1ccc(O)nc1",
        "output": "521"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.O=C1CCCCCCCC(=O)CCCCCCC1.OCCO>>O=C1CCCCCCCC2(CCCCCCC1)OCCO2",
        "output": "265"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](N)C1.CCOc1ccc2c(c1-c1ncnc3c(C(=O)O)c[nH]c13)OCO2>>CCOc1ccc2c(c1-c1ncnc3c(C(=O)N[C@@H]4CCN(C(=O)OC(C)(C)C)C4)c[nH]c13)OCO2",
        "output": "737"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(Br)nc1.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>BrCc1ccc(Br)nc1",
        "output": "625"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCc1ccccc1.CN(C)C=O.COCCc1c(C(C)=O)c(OCOC)cc(OCOC)c1-c1cccc(O)c1.O.O=C([O-])[O-].[K+].[K+]>>COCCc1c(C(C)=O)c(OCOC)cc(OCOC)c1-c1cccc(OCc2ccccc2)c1",
        "output": "127"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CCCc1ccc([C@@H]2CC[C@@H](C=O)CC2)cc1.CCOC(C)=O.N.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CCCc1ccc([C@@H]2CC[C@@H](CO)CC2)cc1",
        "output": "223"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)Cn1nnc(-c2nc3cnc(N4CCC(Oc5cc(F)ccc5Br)CC4)nc3s2)n1.[Na+].[OH-]>>O=C(O)Cn1nnc(-c2nc3cnc(N4CCC(Oc5cc(F)ccc5Br)CC4)nc3s2)n1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CCOC(C)=O.CN(C)C=O.ICCCc1ccco1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)N1CCN(CCCc2ccco2)CC1",
        "output": "184"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "N#Cc1c(Cl)[nH]c2cccnc12.OC[C@H]1CCCN1>>N#Cc1c(N2CCC[C@@H]2CO)[nH]c2cccnc12",
        "output": "296"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CC1(C)Cc2c(c(C(=O)O)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1.CCN(C(C)C)C(C)C.Nc1ccc(C2CC2)cc1.O=S(Cl)Cl>>CC1(C)Cc2c(c(C(=O)Nc3ccc(C4CC4)cc3)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1",
        "output": "50"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.COc1cc2nc(-c3ccccn3)c(C)c(Cl)c2cc1Cl.Cc1ccccc1.Nc1cc(N2CCOCC2)cnc1N1CCOCC1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>COc1cc2nc(-c3ccccn3)c(C)c(Nc3cc(N4CCOCC4)cnc3N3CCOCC3)c2cc1Cl",
        "output": "859"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CO.COc1ccc(C=CC(=O)O)c(OC)c1Cl.[Pd]>>COc1ccc(CCC(=O)O)c(OC)c1Cl",
        "output": "344"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CN(C)C=O.Nc1ccc(-c2ccc(S(=O)(=O)N3C(C(=O)O)CC4CCCC43)cc2)cc1.O=C=Nc1ccccc1>>O=C(Nc1ccccc1)Nc1ccc(-c2ccc(S(=O)(=O)N3C(C(=O)O)CC4CCCC43)cc2)cc1",
        "output": "473"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CNC.COc1cc2c(cc1OC)/C(=C(/Nc1ccc(CCN3CCC(C(=O)O)CC3)cc1)c1ccccc1)C(=O)N2.Cl.F[B-](F)(F)F.O.On1nnc2ccccc21>>COc1cc2c(cc1OC)/C(=C(/Nc1ccc(CCN3CCC(C(=O)N(C)C)CC3)cc1)c1ccccc1)C(=O)N2",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)Oc1cc(F)ccc1F.CN(C)C=O.[Li]C(C)CC>>CC(C)(C)[Si](C)(C)Oc1cc(F)cc(C=O)c1F",
        "output": "239"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1NC2(CCC(NC(=O)OCc3ccccc3)CC2)CC1=O.CO.[Pd]>>CN1NC2(CCC(N)CC2)CC1=O",
        "output": "574"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C=CCCCC(O)c1ccc(Br)cc1.CCOCC.COCCOCCOC.FB(F)F.O.O=C([O-])[O-].OO.[BH4-].[K+].[K+].[Na+].[Na+].[OH-]>>OCCCCCC(O)c1ccc(Br)cc1",
        "output": "465"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCOC(=O)C1(NC(=O)c2cc(Cl)cc(C)c2OC2CCC2)Cc2ccc(F)cc2C1.CO.CO.ClCCl.O.[Li+].[OH-]>>Cc1cc(Cl)cc(C(=O)NC2(C(=O)O)Cc3ccc(F)cc3C2)c1OC1CCC1",
        "output": "7"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CNC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc(Br)cc1F>>O=C(c1ccc(Br)cc1F)N1CCC1",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "O=Cc1cc(F)ccc1Br.O=c1cc(N2CCNCC2)nc[nH]1>>O=c1cc(N2CCN(Cc3cc(F)ccc3Br)CC2)nc[nH]1",
        "output": "567"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CC.COCCCOc1ccnc(CSc2nc3ccccc3n2C)c1C.ClCCl.O=C(OO)c1cccc(Cl)c1.O=C([O-])O.[Na+]>>COCCCOc1ccnc(CS(=O)c2nc3ccccc3n2C)c1C",
        "output": "595"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CO.N.N#Cc1cccc(-n2nc(C(F)(F)F)cc2C(=O)O)c1>>NCc1cccc(-n2nc(C(F)(F)F)cc2C(=O)O)c1",
        "output": "175"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCc1cc(C#C[Si](C)(C)C)ccc1OC(F)F.CO.O=C([O-])[O-].[K+].[K+]>>C#Cc1ccc(OC(F)F)c(CC)c1",
        "output": "337"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCS(=O)(=O)Cl.COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCN>>CCCS(=O)(=O)NCCOc1ncnc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC",
        "output": "493"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CCOCC.ClC(Cl)Cl.N#CCCCCCCBr.c1ccccc1>>N#CCCCCCCN1CCCCC1",
        "output": "73"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COc1ccc(C(=O)/C=C/c2cc(F)cc(F)c2)cn1.Cl>>O=C(/C=C/c1cc(F)cc(F)c1)c1ccc(=O)[nH]c1",
        "output": "758"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O.CCOC(=O)C(Nc1ccc(C(=N)N)cc1)c1cc(OCC)cc(OCC2CCN(C)CC2)c1F.[Li+].[OH-]>>CCOc1cc(OCC2CCN(C)CC2)c(F)c(C(Nc2ccc(C(=N)N)cc2)C(=O)O)c1",
        "output": "7"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCOCCl.Cc1cc(Br)c(C(C)(C)O)cc1Cl.ClCCl.O>>CCOCOC(C)(C)c1cc(Cl)c(C)cc1Br",
        "output": "598"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.Clc1nccc(-c2ccc(Br)s2)n1.NCCN1CCNC1=O>>O=C1NCCN1CCNc1nccc(-c2ccc(Br)s2)n1",
        "output": "544"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(c2cccnc2)CO1.CN(C)C=O.Cc1ccc2[nH]c3c(c2c1)CCN(C)C3.[H-].[Na+]>>Cc1ccc2c(c1)c1c(n2CC(C)(O)c2cccnc2)CN(C)CC1",
        "output": "749"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=[N+]([O-])c1ccc(OC2CCN(C3CCC3)CC2)cc1.[C].[Pd]>>Nc1ccc(OC2CCN(C3CCC3)CC2)cc1",
        "output": "202"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1cn(-c2ccc([N+](=O)[O-])cc2)cn1.O=C[O-].[NH4+].[Pd]>>CCOC(=O)c1cn(-c2ccc(N)cc2)cn1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N1CCCC1c1nc2ccc(Br)cc2[nH]1.COC(=O)NC(C(=O)N1CCCC1c1ncc(-c2ccc(Br)cc2)[nH]1)C(C)C>>Brc1ccc2nc(C3CCCN3)[nH]c2c1",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CCOC(=O)COc1ccc(OCCc2nc(-c3ccccc3)oc2C)c(CC)c1.[Na+].[OH-]>>CCc1cc(OCC(=O)O)ccc1OCCc1nc(-c2ccccc2)oc1C",
        "output": "7"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN1CCCC1=O.Cc1cccc(C#CC=C2CCNCC2)n1.Fc1ccccn1.O>>Cc1cccc(C#CC=C2CCN(c3ccccn3)CC2)n1",
        "output": "756"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=C(C)C(CO)C(C)(C)O.CCN(CC)CC.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl>>C=C(C)C(COS(=O)(=O)c1ccc(C)cc1)C(C)(C)O",
        "output": "197"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.COC(=O)c1ccc(NC(=O)c2cc(COCc3cc(C)on3)cc(OCc3ccccc3F)c2)nc1.[Na+].[OH-]>>Cc1cc(COCc2cc(OCc3ccccc3F)cc(C(=O)Nc3ccc(C(=O)O)cn3)c2)no1",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Cc1ccc(-c2cnn(C)c2)c(C(=O)N2CCC[C@@H](C)[C@H]2CN)c1.Cc1cccnc1Br>>Cc1ccc(-c2cnn(C)c2)c(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ncccc2C)c1",
        "output": "715"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCc2oc3ccc(Br)cc3c2CC1.O=c1cc(OCc2ccccc2)cc[nH]1>>CC(C)(C)OC(=O)N1CCc2oc3ccc(-n4ccc(OCc5ccccc5)cc4=O)cc3c2CC1",
        "output": "349"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCl.Nc1ccccc1Br.O=C(Cl)CBr.c1ccncc1>>O=C(CBr)Nc1ccccc1Br",
        "output": "9"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.CNC1CCN(C)C1.Cc1ccc2[nH]c(-c3cc(N4CCC(C(=O)O)CC4)ccc3Cl)nc2c1.Cl.F[P-](F)(F)(F)(F)F>>Cc1ccc2[nH]c(-c3cc(N4CCC(C(=O)N(C)C5CCN(C)C5)CC4)ccc3Cl)nc2c1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=C.CC#N.COc1ccc2cc(Br)ccc2c1.Cl[Pd]Cl.O>>C=Cc1ccc2cc(OC)ccc2c1",
        "output": "539"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrB(Br)Br.COC(=O)c1ccc(Cn2c(=Nc3ccc(OC)cc3)n(C)c3cc(Cl)c(Cl)cc32)cc1.ClCCl>>COC(=O)c1ccc(Cn2c(=Nc3ccc(O)cc3)n(C)c3cc(Cl)c(Cl)cc32)cc1",
        "output": "402"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.O.O=C(O)c1ccc(Oc2ccc(OCc3ccccc3)cc2)c([N+](=O)[O-])c1.[Cl-].[Fe].[NH4+]>>Nc1cc(C(=O)O)ccc1Oc1ccc(OCc2ccccc2)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.NCCc1ccc(O)cc1>>CC(C)(C)OC(=O)NCCc1ccc(O)cc1",
        "output": "631"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Clc1ccc2c(Cl)ccnc2c1.NCCCO.O>>OCCCNc1ccnc2cc(Cl)ccc12",
        "output": "78"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4cc(CCO[Si](C)(C)C(C)(C)C)cs4)CC3)C2)cs1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4cc(CCO)cs4)CC3)C2)cs1",
        "output": "708"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1=COCCC1.C1CCOC1.O=C([O-])O.OCCCc1ccncc1O.[Na+]>>Oc1cnccc1CCCOC1CCCCO1",
        "output": "141"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(CC)CC.C[C@@H]1CCC[C@](O)(CN)C1.ClCCCl.O=C(O)c1cn(CCC(F)F)c2cccc(Cl)c12.On1nnc2ccccc21>>C[C@@H]1CCC[C@](O)(CNC(=O)c2cn(CCC(F)F)c3cccc(Cl)c23)C1",
        "output": "674"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.ClCCl.O=C(Cl)c1cc(Cl)ccc1F>>COC(=O)c1cc(Cl)ccc1F",
        "output": "51"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N(Cc1ccc2c(c1)OCCO2)C1CCN(CCn2c(=O)ccc3c(O)cccc32)CC1.CCOC(=O)CBr.CN(C)C=O.Cl.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)COc1cccc2c1ccc(=O)n2CCN1CCC(N(Cc2ccc3c(c2)OCCO3)C(=O)OC(C)(C)C)CC1",
        "output": "123"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)O[C@H]1COC[C@H]1NC(=O)OCc1ccccc1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.[F-]>>O=C(N[C@@H]1COC[C@@H]1O)OCc1ccccc1",
        "output": "708"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCC[N+](CCCC)(CCCC)CCCC.CSc1ccc(CCl)cc1.Cc1ccccc1.O.[C-]#N.[Cl-].[Na+]>>CSc1ccc(CC#N)cc1",
        "output": "38"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COC(=O)C(CCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)N1CCN(c2cccc(C(F)(F)F)c2)C(C)C1=O.[BH4-].[Na+]>>CC1C(=O)N(C(CO)CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CCN1c1cccc(C(F)(F)F)c1",
        "output": "343"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Cl.O=C(O)c1ccc(Cl)cc1S>>COC(=O)c1ccc(Cl)cc1S",
        "output": "33"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COCCO[Al+]OCCOC.Cc1ccccc1.O=C(N1CCCCC(CO)C1)C1(c2ccc(Cl)cc2)CCC1.[H-].[H-].[Na+]>>OCC1CCCCN(CC2(c3ccc(Cl)cc3)CCC2)C1",
        "output": "112"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CNCC(O)c1cccc(N)c1.Cc1c(CCl)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12>>Cc1c(CN(C)CC(O)c2cccc(N)c2)sc2c(=O)c(C(=O)NCc3ccc(Cl)cc3)cn(C)c12",
        "output": "639"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.C=Cc1cc(Oc2ccc(NS(=O)(=O)c3ccc(C)cc3)c(C(=O)OC)c2)ccc1[N+](=O)[O-].CO.O.[Cl-].[Fe].[NH4+]>>C=Cc1cc(Oc2ccc(NS(=O)(=O)c3ccc(C)cc3)c(C(=O)OC)c2)ccc1N",
        "output": "335"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "N[C@H]1CCCc2ccccc21.O=Cc1cc(F)cc(F)c1>>Fc1cc(F)cc(CN[C@H]2CCCc3ccccc32)c1",
        "output": "683"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN1CCNCC1.Cc1cc2ccccc2nc1Cl>>CCN1CCN(c2nc3ccccc3cc2C)CC1",
        "output": "220"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CN2CCN1CC2.CN(C(=O)Cl)c1ccccc1.Cc1cccc(Cc2ccc(O)cc2)n1.ClCCl>>Cc1cccc(Cc2ccc(OC(=O)N(C)c3ccccc3)cc2)n1",
        "output": "425"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)C1CC1.O=C(N[C@@H](Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21>>O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)C1CC1)OCC1c2ccccc2-c2ccccc21",
        "output": "133"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)OC(=O)N[C@H](C(=O)N[C@H](CN)C(C)C)C(C)C.CCN(CC)CC.CCOC(C)=O.ClCCl.O=C(Cl)c1cccc2onnc12>>CC(C)OC(=O)N[C@H](C(=O)N[C@H](CNC(=O)c1cccc2onnc12)C(C)C)C(C)C",
        "output": "353"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrCC1CC1.CC(C)=O.COC(=O)c1ccc(O)c(OC)c1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>COC(=O)c1ccc(OCC2CC2)c(OC)c1",
        "output": "385"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.CCOC(=O)Cc1ccc(CC)c(OC)c1.ClCCl>>CCOC(=O)Cc1ccc(CC)c(O)c1",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.CCOC(C)=O.O.O=[N+]([O-])c1cc(C[C@@H](CO)N(Cc2ccccc2)C[C@H](O)COc2ccccc2)ccc1OCc1ccccc1.[Cl-].[Fe].[NH4+]>>Nc1cc(C[C@@H](CO)N(Cc2ccccc2)C[C@H](O)COc2ccccc2)ccc1OCc1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCCCBr.CC#N.Cc1cccc(O)c1NC(=O)OC(C)(C)C.O=C([O-])[O-].[K+].[K+]>>Cc1cccc(OCCCBr)c1NC(=O)OC(C)(C)C",
        "output": "75"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCOC(=O)c1cc(Cl)cc(C(=O)OCC)n1.COCCOC.COc1ccc(Cl)cc1B(O)O.O.O=C([O-])[O-].[Na+].[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1cc(-c2cc(Cl)ccc2OC)cc(C(=O)OCC)n1",
        "output": "947"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CSc1nc(Cl)c2ccc(=O)n(-c3ccc(F)cc3F)c2n1.ClCCl.O=C(OO)c1cccc(Cl)c1>>CS(=O)c1nc(Cl)c2ccc(=O)n(-c3ccc(F)cc3F)c2n1",
        "output": "595"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CC(N2CCOCC2)CCN1.N#CCBr>>N#CCN1CCC(N2CCOCC2)CC1",
        "output": "880"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)O)CC2)nc1CN1CCCC1=O.Cc1ccc(CS(N)(=O)=O)cc1>>CCOC(=O)c1cc(C#N)c(N2CCC(C(=O)NS(=O)(=O)Cc3ccc(C)cc3)CC2)nc1CN1CCCC1=O",
        "output": "644"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCCCCCBr.OCCc1cc2ccccc2o1.[Na+].[OH-]>>BrCCCCCOCCc1cc2ccccc2o1",
        "output": "95"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCSc1ncc[nH]1.CN1CCCC1=O.Cn1c(Cl)nc2cc(C(F)(F)F)cnc21.O.[H-].[Na+]>>CCSc1nccn1-c1nc2cc(C(F)(F)F)cnc2n1C",
        "output": "916"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CO.Cc1nc(CC2CCN(c3ccc(C(C)(C)C)cc3)CC2)nc(C(=O)OC(C)(C)C)c1OCc1ccccc1.Cl.[Na+].[OH-]>>Cc1nc(CC2CCN(c3ccc(C(C)(C)C)cc3)CC2)nc(C(=O)O)c1OCc1ccccc1",
        "output": "569"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)C(=O)OCC.CC[O-].COc1ccc2cc(CCCC(C)=O)ccc2c1.[Na+]>>CCOC(=O)C(=O)CC(=O)CCCc1ccc2cc(OC)ccc2c1",
        "output": "526"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC=C1CCc2ccc(Br)cc21.CCOC(C)=O.[H][H].[Pd]>>CCC1CCc2ccc(Br)cc21",
        "output": "249"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.COC(=O)c1sc(NC(=O)OC(C)(C)C)c(C#N)c1C.O.[Na+].[OH-]>>Cc1c(C(=O)O)sc(NC(=O)OC(C)(C)C)c1C#N",
        "output": "152"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.COC(=O)/C=C/[C@@H]1[C@@H](C(=O)Cl)C1(C)C.ClC(Cl)Cl.c1ccccc1>>CCOC(=O)[C@@H]1[C@@H](/C=C/C(=O)OC)C1(C)C",
        "output": "126"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)(CN)CC1.ClCCl.O=C(Cl)c1ccc(F)cc1F.c1ccncc1>>CC(C)(C)OC(=O)N1CCC(N)(CNC(=O)c2ccc(F)cc2F)CC1",
        "output": "271"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)[O-].CCCCCC.CCO.CCOC(C)=O.Cl.NO.O.O=C1CCCc2cc(Cl)cc(F)c21.[Na+]>>ON=C1CCCc2cc(Cl)cc(F)c21",
        "output": "212"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.CC(C)(C)c1ccc(NC(=O)c2ccc(-c3ncccc3C(F)(F)F)cc2)cc1OCCO[Si](C)(C)C(C)(C)C.Cc1ccc(S(=O)(=O)O)cc1.O>>CC(C)(C)c1ccc(NC(=O)c2ccc(-c3ncccc3C(F)(F)F)cc2)cc1OCCO",
        "output": "708"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.C=C(F)c1ccccc1CC(=O)OC.O.O.[Li+].[OH-]>>C=C(F)c1ccccc1CC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.O=C(CCl)N1CCN(C2CCC2)CC1.O=C(OCc1ccccc1)N1CCNCC1.O=C([O-])[O-].[I-].[K+].[K+].[Na+]>>O=C(CN1CCN(C(=O)OCc2ccccc2)CC1)N1CCN(C2CCC2)CC1",
        "output": "340"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.COc1ncccc1N.CSc1cccc(Oc2ncc(F)cc2C(=O)O)c1.Cl.On1nnc2ccccc21>>COc1ncccc1NC(=O)c1cc(F)cnc1Oc1cccc(SC)c1",
        "output": "863"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C=C(C(=O)OC)c1ccc(-c2ccc(-c3nc(C(N)=O)c(C)nc3C)cc2F)c(Cl)c1.CC(C)(C)O.CCOC(C)=O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[K+].[OH-]>>C=C(C(=O)O)c1ccc(-c2ccc(-c3nc(C(N)=O)c(C)nc3C)cc2F)c(Cl)c1",
        "output": "58"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COC(=O)C12CC3CC(C1)CC(c1ncc(-c4ccc(NC(=O)Nc5cc(F)cc(F)c5)cc4)s1)(C3)C2.O=C(O)CCc1ncc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)s1>>O=C(Nc1ccc(-c2cnc(C34CC5CC(CC(C(=O)O)(C5)C3)C4)s2)cc1)Nc1cc(F)cc(F)c1",
        "output": "361"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1cc2cc(C#N)c(=O)[nH]c2cc1C.O=P(Cl)(Cl)Cl>>Cc1cc2cc(C#N)c(Cl)nc2cc1C",
        "output": "100"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CNc1nn(Cc2cc(Cl)cc3cnn(CC(C)C)c23)c2ccc(C(=O)OC)cc12.CO.O.[Li+].[OH-]>>CNc1nn(Cc2cc(Cl)cc3cnn(CC(C)C)c23)c2ccc(C(=O)O)cc12",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CC(C)[Mg]Cl.COB(OC)OC.CSc1c(F)cc(F)cc1Br>>CSc1c(F)cc(F)cc1B(O)O",
        "output": "789"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)N1CCC(S)CC1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCN(C(C)C)C(C)C.Cc1cccnc1-c1cn2c(n1)-c1cc(Br)ccc1OCC2.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]>>Cc1cccnc1-c1cn2c(n1)-c1cc(SC3CCN(C(C)C)CC3)ccc1OCC2",
        "output": "824"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.Cl.O.O=C(c1ccc(Cl)nn1)c1cc(-c2ncnc3cc(N4CCOCC4)ccc23)c(F)cc1Cl.OC1COC1.[H-].[Na+]>>O=C(c1ccc(OC2COC2)nn1)c1cc(-c2ncnc3cc(N4CCOCC4)ccc23)c(F)cc1Cl",
        "output": "407"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.Cc1cc(N)ccc1C1CN=C2c3ccccc3NC(=O)N2C1.ClCCl.O=C=Nc1cc(C(F)(F)F)ccc1F>>Cc1cc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)ccc1C1CN=C2c3ccccc3NC(=O)N2C1",
        "output": "473"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)Cc1ccc(Nc2ccccc2[N+](=O)[O-])cc1.[Pd]>>COC(=O)Cc1ccc(Nc2ccccc2N)cc1",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)/C=C/c1c(N2CCCC(CC(=O)NCCO)C2)nc2cc(C(=O)Nc3nc(C(C)(C)C)cs3)ccn2c1=O.Cl>>CC(C)(C)c1csc(NC(=O)c2ccn3c(=O)c(/C=C/C(=O)O)c(N4CCCC(CC(=O)NCCO)C4)nc3c2)n1",
        "output": "158"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.CN1CCCC1=O.Cc1c(-c2ccccn2)nc2cc(F)ccc2c1Cl.Cl.Nc1cc(N2CCSCC2)cnc1N1CCOCC1>>Cc1c(-c2ccccn2)nc2cc(F)ccc2c1Nc1cc(N2CCSCC2)cnc1N1CCOCC1",
        "output": "859"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CS(=O)(=O)c1ccc([C@@H](O)[C@H](N)CF)cc1.ClCCl.O.O=C(Cl)C(Cl)Cl>>CS(=O)(=O)c1ccc([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)cc1",
        "output": "45"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1cc(-c2ccccc2)ccc1CN1CCN(C(=O)OC(C)(C)C)CC1.ClCCl.O=C(O)C(F)(F)F>>COc1cc(-c2ccccc2)ccc1CN1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)c1ccccc1.COCCOCOc1ccc(CON=C(C(=O)O)c2csc(NC(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1OCOCCOC.NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(CCl)CS[C@H]12.O=P(Cl)(Cl)Cl>>COCCOCOc1ccc(CON=C(C(=O)NC2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(CCl)CS[C@H]23)c2csc(NC(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1OCOCCOC",
        "output": "587"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1sc2cc(O)ccc2c1-c1ccc(C(F)(F)F)cc1.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.c1ccncc1>>Cc1sc2cc(OS(=O)(=O)C(F)(F)F)ccc2c1-c1ccc(C(F)(F)F)cc1",
        "output": "731"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C#CCBr.CC(C)=O.O=C([O-])[O-].Oc1ccc(O)cc1.[K+].[K+]>>C#CCOc1ccc(O)cc1",
        "output": "154"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=C(Cc1ccccn1)c1ccc(Br)cc1.[BH4-].[Na+]>>OC(Cc1ccccn1)c1ccc(Br)cc1",
        "output": "24"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.O=C([O-])[O-].O=[N+]([O-])c1ccc(C2CCNCC2)cc1.OCCBr.[K+].[K+]>>O=[N+]([O-])c1ccc(C2CCN(CCO)CC2)cc1",
        "output": "73"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)N(C)C.NCCN.O.O=C(O)c1cn(C2CC2)c2cc(Cl)c(F)cc2c1=O>>NCCNc1cc2c(=O)c(C(=O)O)cn(C3CC3)c2cc1Cl",
        "output": "572"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.CC(C)S(=O)(=O)c1ccccc1Nc1nc(Cl)ncc1Cl.CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2.COCCN1CCc2ccc(N)cc2CC1.O=C([O-])[O-]>>COCCN1CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)cc2CC1",
        "output": "808"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.C=O.CC(C)(C)OC(=O)N1CCCN(C(=O)[C@@H]2CSCN2C(=O)OCc2ccccc2)CC1.Cl.[BH3-]C#N.[Na+]>>CN1CCCN(C(=O)[C@@H]2CSCN2C(=O)OCc2ccccc2)CC1",
        "output": "881"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cc1c(F)c([N+](=O)[O-])c(Cl)c(F)c1N1CCN(C)CC1.NC1CC1.[F-].[K+]>>Cc1c(NC2CC2)c([N+](=O)[O-])c(Cl)c(F)c1N1CCN(C)CC1",
        "output": "572"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.COC(=O)C1CC(O)CN(C(=O)OC(C)(C)C)C1.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>COC(=O)C1CC(=O)CN(C(=O)OC(C)(C)C)C1",
        "output": "650"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "ClCCl.O=C(Cl)c1ccccc1.OCCCCO>>O=C(OCCCCO)c1ccccc1",
        "output": "51"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(CO)N1CCC(Sc2ccc3c(c2)-c2nc(-c4ccccn4)cn2CCO3)CC1.ClCCl.O=C(O)C(F)(F)F.O=C(OO)c1cccc(Cl)c1>>CC(C)(CO)N1CCC(S(=O)c2ccc3c(c2)-c2nc(-c4ccccn4)cn2CCO3)CC1",
        "output": "500"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.COC(=O)c1cc(-c2ccccc2)cc([N+](=O)[O-])c1C.O=C[O-].[NH4+].[Pd]>>COC(=O)c1cc(-c2ccccc2)cc(N)c1C",
        "output": "481"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCc1nc(C)c(-c2ccc(OC(C)C)cc2)c(=O)n1Cc1ccc(-c2ccccc2C#N)cc1.CCOC(C)=O.CS(C)=O.Cl.NO.O=C([O-])O.[Na+]>>CCCCc1nc(C)c(-c2ccc(OC(C)C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1",
        "output": "979"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.CNCCO.Cc1nc2c3c(c(C(=O)O)cc2n1C)CCC1(Cc2ccccc2C1)N3.F[B-](F)(F)F>>Cc1nc2c3c(c(C(=O)N(C)CCO)cc2n1C)CCC1(Cc2ccccc2C1)N3",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCSc1nc(N2CCOCC2)nc(C)c1C(=O)OC.[Na+].[OH-]>>CCSc1nc(N2CCOCC2)nc(C)c1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN(C)C=O.Cc1ccccc1.O=C(O)c1cc(Cl)nnc1Cl.O=S(Cl)Cl>>O=C(Cl)c1cc(Cl)nnc1Cl",
        "output": "188"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccccc1C(CC(=O)c1cc(F)ncc1Cl)c1ccc(Br)cc1.Cl.NO.O=C([O-])O.[Na+]>>Cc1ccccc1C(CC(=NO)c1cc(F)ncc1Cl)c1ccc(Br)cc1",
        "output": "212"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CCOC(C)=O.CCOCC.Cc1cc(CN=[N+]=[N-])ccc1NC(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1.Cl.O.[Na+].[OH-].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(CN)ccc1NC(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1",
        "output": "562"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrC(Br)(Br)Br.C#CCCCCCCCCCO.C1CCCCC1.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C#CCCCCCCCCCBr",
        "output": "378"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CN(c1cc2c(cn1)ncn2C)c1ccc(CN)cc1F.CS(=O)(=O)Cl.ClCCl>>CN(c1cc2c(cn1)ncn2C)c1ccc(CNS(C)(=O)=O)cc1F",
        "output": "742"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.Cc1cc(C)c(S(=O)(=O)N(Cc2cccc(OC3CCCCO3)c2)c2ccc(OCc3ccccc3)cc2)c(C)c1.O=C[O-].[NH4+].[Pd]>>Cc1cc(C)c(S(=O)(=O)N(Cc2cccc(OC3CCCCO3)c2)c2ccc(O)cc2)c(C)c1",
        "output": "698"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COCCOC.Cl[Pd]Cl.O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)c(Br)c1.OB(O)c1ccncc1F.[Fe+2].[Na+].[Na+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>O=[N+]([O-])c1ccc(Cl)c(-c2ccncc2F)c1",
        "output": "904"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)C=Cc2c(cc(O)c3c(=O)c4c(ccc5ccccc54)[nH]c23)O1.CN(C)C=O.COS(=O)(=O)OC.[H-].[Na+]>>COc1cc2c(c3[nH]c4ccc5ccccc5c4c(=O)c13)C=CC(C)(C)O2",
        "output": "317"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)Cc1cc(Nc2nc(CCc3ccccc3)cs2)ncc1Br.Cl.[Na+].[OH-]>>O=C(O)Cc1cc(Nc2nc(CCc3ccccc3)cs2)ncc1Br",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrCCOc1ccc2ncccc2c1.CCOC(C)=O.O=C(OO)c1cccc(Cl)c1>>[O-][n+]1cccc2cc(OCCBr)ccc21",
        "output": "262"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC2(CCN(c3ncc(C(F)(F)F)cn3)CC2)C1.ClCCl.O=C(O)C(F)(F)F>>FC(F)(F)c1cnc(N2CCC3(CCNC3)CC2)nc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCNC(=O)c1ccc2n1CCNC2C.O=C(O)c1cc2ncc(Br)cn2n1>>CCNC(=O)c1ccc2n1CCN(C(=O)c1cc3ncc(Br)cn3n1)C2C",
        "output": "663"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.COc1cc(Nc2ncnc(-c3ccc(O[C@@H]4CCNC4)c(C#N)c3)n2)ccc1N1CCN(C2COC2)CC1.ClCCl.F[P-](F)(F)(F)(F)F.O=C(O)CO>>COc1cc(Nc2ncnc(-c3ccc(O[C@@H]4CCN(C(=O)CO)C4)c(C#N)c3)n2)ccc1N1CCN(C2COC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1COCCO1.CCOCC.COc1cccc(OC)c1C.O.[Br-].[Br-]>>COc1ccc(Br)c(OC)c1C",
        "output": "784"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCCCCCCCCCC(N)c1coc([Si](C)(C)C)c1.CCN(CC)CC.ClCCl.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>CCCCCCCCCCCCC(NC(=O)C(F)(F)F)c1coc([Si](C)(C)C)c1",
        "output": "316"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=N)NO.COC1CN(C(=O)N2CC(C(=O)O)CC(c3ccc(C(F)(F)F)cc3)C2)C1>>COC1CN(C(=O)N2CC(c3ccc(C(F)(F)F)cc3)CC(c3nc(C)no3)C2)C1",
        "output": "924"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCc1cccc(CC)c1NC(=O)c1nn(C)c2c1CCc1cnc(Nc3ccc([N+](=O)[O-])cc3OC)nc1-2.O.[Cl-].[NH4+].[Zn]>>CCc1cccc(CC)c1NC(=O)c1nn(C)c2c1CCc1cnc(Nc3ccc(N)cc3OC)nc1-2",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=C(C)C.CC(=O)SCC(C(=O)O)C1CCN(C(=O)OCc2ccccc2)CC1.ClCCl.O=S(=O)(O)O>>CC(=O)SCC(C(=O)OC(C)(C)C)C1CCN(C(=O)OCc2ccccc2)CC1",
        "output": "511"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CCS.CN(C)C=O.N#Cc1cc([N+](=O)[O-])ccc1F.O>>CCSc1ccc([N+](=O)[O-])cc1C#N",
        "output": "503"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)[C@@H]1C[C@H](C(=O)OCc2ccccc2)C1(C)C.Cl.O>>CC1(C)[C@H](C(=O)O)C[C@@H]1C(=O)OCc1ccccc1",
        "output": "278"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOCC.COC(=O)c1cccc(S(=O)(=O)N(C)C)c1C.ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>COC(=O)c1cccc(S(=O)(=O)N(C)C)c1CBr",
        "output": "545"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CCn1c(CC)nc2cnc3ccccc3c21.CCN(CC)CC.CN(C)C=O.COc1ccc(I)cc1.ClC(Cl)Cl.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Cu]I.[Pd].[Pd]>>CCc1nc2cnc3ccccc3c2n1CC#Cc1ccc(OC)cc1",
        "output": "664"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COC(=O)CCc1oc(Sc2ccc(O)cc2)nc1-c1ccccc1.Cc1oc(-c2ccccc2)nc1CCl.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)CCc1oc(Sc2ccc(OCc3nc(-c4ccccc4)oc3C)cc2)nc1-c1ccccc1",
        "output": "760"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.C[Si](C)(C)c1cc(Cl)nnc1Cl.NN>>C[Si](C)(C)c1cc(NN)nnc1Cl",
        "output": "284"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)c1cc([N+](=O)[O-])c(C(F)(F)F)cc1OC.Cl.O.[Li+].[OH-]>>COc1cc(C(F)(F)F)c([N+](=O)[O-])cc1C(=O)O",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CN1CCCC1CCOC(=O)Nc1ccccc1I.Cc1ccccc1.N#Cc1ccc(B(O)O)cc1.O=C([O-])[O-].[K+].[K+]>>CN1CCCC1CCOC(=O)Nc1ccccc1-c1ccc(C#N)cc1",
        "output": "855"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.C[C@H](N)CO.Cc1c(F)cc(C(=O)O)cc1-c1ccc(C(=O)NCC(C)(C)C)cc1C(N)=O.F[P-](F)(F)(F)(F)F>>Cc1c(F)cc(C(=O)N[C@@H](C)CO)cc1-c1ccc(C(=O)NCC(C)(C)C)cc1C(N)=O",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.C=CC(=O)Nc1cc([N+](=O)[O-])ccc1N1CCN(C)CC1.O.O.[Cl-].[NH4+].[Zn]>>C=CC(=O)Nc1cc(N)ccc1N1CCN(C)CC1",
        "output": "1"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C#Cc1cnn2c(C(F)(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12.Nc1cncc(Br)c1>>Nc1cncc(C#Cc2cnn3c(C(F)(F)F)cc(-c4ccc(C(F)(F)F)cc4)nc23)c1",
        "output": "719"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrC(Br)(Br)Br.C[Si](C)(C)CCOCOc1cc(-c2ccccc2CCCO)cc2c(=O)n(COCC[Si](C)(C)C)cnc12.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>C[Si](C)(C)CCOCOc1cc(-c2ccccc2CCCBr)cc2c(=O)n(COCC[Si](C)(C)C)cnc12",
        "output": "378"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(=O)O.NS(=O)(=O)c1ccc(OCC2(F)CCNCC2)c(Cl)c1.O=C1COC1.[BH3-]C#N>>NS(=O)(=O)c1ccc(OCC2(F)CCN(C3COC3)CC2)c(Cl)c1",
        "output": "983"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccc2N)CC1.CS(=O)(=O)Cl.ClCCl>>COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccc2NS(C)(=O)=O)CC1",
        "output": "194"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.CCS(=O)(=O)c1cccc(-c2cnc(Cl)c3[nH]c4ncc(C)cc4c23)c1.CC[O-].[Na+]>>CCOc1ncc(-c2cccc(S(=O)(=O)CC)c2)c2c1[nH]c1ncc(C)cc12",
        "output": "209"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1ccc(N(C)C(=O)Cc2ccc3c(c2)C(C)(C)CCC3(C)C)cc1.[Na+].[OH-]>>CN(C(=O)Cc1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccc(C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)c1ccc(NC(=O)c2ccc(-c3ncccc3N)cc2)cc1.COC(=O)Cl.COCCOC.O=C([O-])[O-].[K+].[K+]>>COC(=O)Nc1cccnc1-c1ccc(C(=O)Nc2ccc(C(C)(C)C)cc2)cc1",
        "output": "763"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COc1cc2c(=O)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)oc2cc1C#N.NC1(c2ccc(-c3c(-c4ccccc4)oc4ccc(F)cc4c3=O)cc2)CCC1>>COc1cc2c(=O)c(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)oc2cc1C#N",
        "output": "793"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC(N)C1.CCN(C(C)C)C(C)C.CS(C)=O.C[C@H]1COCCN1c1nc(Cl)c(CCO)c(Cl)n1.O>>C[C@H]1COCCN1c1nc(Cl)c(CCO)c(NC2CN(C(=O)OC(C)(C)C)C2)n1",
        "output": "166"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)COC1CCC(Nc2ccc([N+](=O)[O-])c(C(F)(F)F)c2)CC1.ClCCl.O=C(O)C(F)(F)F>>O=C(O)COC1CCC(Nc2ccc([N+](=O)[O-])c(C(F)(F)F)c2)CC1",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.COc1cc2c(SC)cc(CO)nc2c2ncccc12.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>COc1cc2c(SC)cc(C=O)nc2c2ncccc12",
        "output": "263"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCS.CN(C)C=O.ClCCl.Clc1cccc(-c2nn3ccccc3c2-c2ccnc3ccccc23)n1.[H-].[Na+]>>CCSc1cccc(-c2nn3ccccc3c2-c2ccnc3ccccc23)n1",
        "output": "333"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCCCCCn1cc(-c2ccccc2)c(C)c([N+](=O)[O-])c1=O.CCOC(C)=O.[Pd]>>CCCCCCn1cc(-c2ccccc2)c(C)c(N)c1=O",
        "output": "269"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCNCCN(C)C.O=C(Nc1ccccc1-c1nnc(C2CCOC2)s1)c1cc(Cl)nc(-c2ccccc2)n1>>CCN(CCN(C)C)c1cc(C(=O)Nc2ccccc2-c2nnc(C3CCOC3)s2)nc(-c2ccccc2)n1",
        "output": "162"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ccc(B(O)O)cn1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCC[C@H](O)C2)c(Br)c1>>Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CCC[C@H](O)C2)cn1",
        "output": "883"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)CBr.CCCC[N+](CCCC)(CCCC)CCCC.COC(=O)c1ccc(Oc2ccc(CO)cc2)cc1.Cc1ccccc1.O.O=S(=O)([O-])O.[Na+].[OH-]>>COC(=O)c1ccc(Oc2ccc(COCC(=O)OC(C)(C)C)cc2)cc1",
        "output": "669"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)Cc1ccc(-n2nc(C(C)(C)C)cc2N)cc1.O=C(O)Cc1ccc(-n2cnc3cccnc32)cc1>>CN(C)Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Cc2ccc(-n3cnc4cccnc43)cc2)cc1",
        "output": "795"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1cc(C2CC2)c2c(C)c(-c3cc(Cl)c(N)c(Cl)c3)ccn2c1=O.CCOC(C)=O.Cl.O.[Li+].[OH-]>>Cc1c(-c2cc(Cl)c(N)c(Cl)c2)ccn2c(=O)c(C(=O)O)cc(C3CC3)c12",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrBr.CC(=O)O.O.O=C(c1ccc(Cl)c(Cl)c1)N1CCc2ccccc21.O=S([O-])O.[Na+]>>O=C(c1ccc(Cl)c(Cl)c1)N1CCc2cc(Br)ccc21",
        "output": "98"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.CCN(CC)CC.CCN=C=NCCCN(C)C.CCOC(C)=O.COCCn1cc(C(=O)N2CCC(c3cc(CN)ccc3F)CC2)c2c(OC(F)(F)F)ccc(F)c21.Cl.ClCCl.On1nnc2ccccc21>>COCCn1cc(C(=O)N2CCC(c3cc(CNC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)ccc3F)CC2)c2c(OC(F)(F)F)ccc(F)c21",
        "output": "599"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.ClCCl.NN.O.O=C1c2ccccc2C(=O)N1CCC#Cc1cccc(CF)n1>>NCCC#Cc1cccc(CF)n1",
        "output": "242"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CI.CN(C)C=O.Cl.OB1OCc2ccc(O)cc21.[H-].[Na+]>>COc1ccc2c(c1)B(O)OC2",
        "output": "62"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.C[Si](C)(C)C#Cc1cncc(Br)c1.[K+].[OH-]>>C#Cc1cncc(Br)c1",
        "output": "337"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.Nc1ccnc(-c2ccccn2)c1[N+](=O)[O-].[Pd]>>Nc1ccnc(-c2ccccn2)c1N",
        "output": "269"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cccc(C(=O)Cl)c1.Cc1cc(Nc2ncnc3cnc(F)cc23)ccc1OC1CCN(C(=O)C2CCCC2)CC1.Cc1cc(Nc2ncnc3cnc(N4CCOCC4)cc23)ccc1OC1CCNCC1>>COc1cccc(C(=O)N2CCC(Oc3ccc(Nc4ncnc5cnc(N6CCOCC6)cc45)cc3C)CC2)c1",
        "output": "201"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CNC(=O)c1cccc2ccccc12.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>CNCc1cccc2ccccc12",
        "output": "215"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)N(CCCl)S(=O)(=O)c1cc(Cl)c(Cl)cc1Cl.c1ccc2[nH]c(N3CCNCC3)nc2c1>>CC(C)N(CCN1CCN(c2nc3ccccc3[nH]2)CC1)S(=O)(=O)c1cc(Cl)c(Cl)cc1Cl",
        "output": "138"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O.CC=O.CCOC(C)=O.CO.Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(NCC3(N)COC3)c2c1.[BH3-]C#N.[Na+]>>CCNC1(CNc2cc(N3CCS(=O)(=O)c4ccccc4C3)nc3ccc(C)cc23)COC1",
        "output": "426"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(F)c(B(O)O)c1.Nc1c2c(nc3c(Br)cccc13)CN(C1CC1)C2=O>>COc1ccc(F)c(-c2cccc3c(N)c4c(nc23)CN(C2CC2)C4=O)c1",
        "output": "833"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCCCCCCCN.CCO.Clc1ccc(OCCBr)c(Cl)c1.O.O=C([O-])[O-].[Na+].[Na+]>>CCCCCCCCNCCOc1ccc(Cl)cc1Cl",
        "output": "147"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "B1C2CCCC1CCC2.C1CCOC1.C=CCC1(NC(=O)OC(C)(C)C)CCC(Oc2cc3ccnc(OCc4ccccc4)c3cc2Cl)CC1.OO.[Na+].[OH-]>>CC(C)(C)OC(=O)NC1(CCCO)CCC(Oc2cc3ccnc(OCc4ccccc4)c3cc2Cl)CC1",
        "output": "465"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CN(C)C=O.O.O=C([O-])[O-].O=[N+]([O-])c1cccc(O)c1.OCCOCCOCCCl.[K+].[K+]>>O=[N+]([O-])c1cccc(OCCOCCOCCO)c1",
        "output": "74"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)CSc1nc(Cl)cc(Cl)n1.Nc1ccc(Cl)cc1.O=C([O-])[O-].[Na+].[Na+]>>CCOC(=O)CSc1nc(Cl)cc(Nc2ccc(Cl)cc2)n1",
        "output": "161"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)c1ccc(OC2CCOCC2)cc1.O.[Na+].[OH-]>>O=C(O)c1ccc(OC2CCOCC2)cc1",
        "output": "222"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)OC(C)=O.CCN(CC)CC.CNC1C(C)(C)c2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc2C1(C)C.ClCCl>>CC(=O)N(C)C1C(C)(C)c2ccc(CCN3CCN(c4nsc5ccccc45)CC3)cc2C1(C)C",
        "output": "369"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.COc1ccc2[nH]c3c(C(=O)O)cc(-c4c(C)noc4C)cc3c2c1.ClCCCl.ClCCl.On1nnc2ccccc21.[NH4+].[OH-]>>COc1ccc2[nH]c3c(C(N)=O)cc(-c4c(C)noc4C)cc3c2c1",
        "output": "704"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(C(=O)O)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)cc1.Cl.F[P-](F)(F)(F)(F)F.N[C@@H]1C[C@@H](CO)NC1=O.O>>Cc1cc(C(=O)N[C@@H]2C[C@@H](CO)NC2=O)ccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CC[C@@H](CNC(=O)OC(C)(C)C)CC2)C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)cc1",
        "output": "718"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(CCO)CC1.CCN(C(C)C)C(C)C.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)N1CCC(CC=O)CC1",
        "output": "142"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCN(C(=O)c2ncn(C3CCCCC3(O)CCC#N)c2-c2ccccc2)[C@H](Cc2ccccc2)C1.CCO.N.[Co]>>CC(C)(C)OC(=O)N1CCN(C(=O)c2ncn(C3CCCCC3(O)CCCN)c2-c2ccccc2)[C@H](Cc2ccccc2)C1",
        "output": "246"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(C)=O.CO.COC(=O)c1ccc2c(c1)C(=O)N(Cc1ccccc1)C2.Cl.O>>O=C(O)c1ccc2c(c1)C(=O)N(Cc1ccccc1)C2",
        "output": "247"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCC(C(=O)O)CC3)cc12.Cl.NCc1ccccc1.O.On1nnc2ccccc21>>COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCC(C(=O)NCc4ccccc4)CC3)cc12",
        "output": "599"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)[C@H](CNC(=O)c1cccs1)NC(=O)c1c(C)nc(NCC#Cc2cc(O)cc(F)c2)nc1C.[Pd]>>COC(=O)[C@H](CNC(=O)c1cccs1)NC(=O)c1c(C)nc(NCCCc2cc(O)cc(F)c2)nc1C",
        "output": "717"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1cncc2c1CCCN2.CCOC(C)=O.CN(C)C=O.CN1C(=O)CCc2cc(B3OC(C)(C)C(C)(C)O3)ccc21.Cl.Cl[Pd]Cl.O=C([O-])[O-].[Na+].[Na+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CN1C(=O)CCc2cc(-c3cncc4c3CCCN4)ccc21",
        "output": "938"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COC(C)(C)C.O=C(Cl)Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1.c1ccc(CCCN2CCNCC2)nc1>>O=C(Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1)N1CCN(CCCc2ccccn2)CC1",
        "output": "219"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1c(Br)cccc1[N+](=O)[O-].ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>O=[N+]([O-])c1cccc(Br)c1CBr",
        "output": "29"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(C)=O.CCN1CCCC[C@H]1C(=O)N1CCN(C(c2ccccc2)c2ccccc2)CC1.Cl.O=C([O-])O.[Na+]>>CCN1CCCC[C@H]1CN1CCN(C(c2ccccc2)c2ccccc2)CC1",
        "output": "490"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.COC(=O)c1ccc(CN[C@@H]2CC[C@@H](O)CC2)cc1.[Na+].[OH-]>>COC(=O)c1ccc(CN(C(=O)OC(C)(C)C)[C@@H]2CC[C@@H](O)CC2)cc1",
        "output": "867"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(C)=O.COc1cc([N+](=O)[O-])ccc1-n1cccc(CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c1=O.O=C[O-].[NH4+].[Pd]>>COc1cc(N)ccc1-n1cccc(CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c1=O",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CCOC(C)=O.CN(C)C=O.OCCc1ccc(CCO)cc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCc1ccc(CCO)cc1",
        "output": "193"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(C)=O.CN1CCNCC1.CS(C)=O.O.O=c1cc(OCc2ccccc2)ccn1-c1ccc(Cl)nc1.[Cs+].[F-]>>CN1CCN(c2ccc(-n3ccc(OCc4ccccc4)cc3=O)cn2)CC1",
        "output": "220"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C#N)c1cc(C(=O)O)ccn1.CN(C)C=O.Cc1ncc(N)cc1Br.ClCCCl.O.On1nnc2cccnc21>>Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1Br",
        "output": "759"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=Cc1cnc(NC(C)=O)c(C)c1.CN1CCCC1=O.CN1CCc2[nH]c3ccc(Cl)cc3c2C1.[K+].[OH-]>>CC(=O)Nc1ncc(CCn2c3c(c4cc(Cl)ccc42)CN(C)CC3)cc1C",
        "output": "986"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)CC1CCC(N(CCSC)C(=O)OC(C)(C)C)CC1.CO.Cl.[Na+].[OH-]>>CSCCN(C(=O)OC(C)(C)C)C1CCC(CC(=O)O)CC1",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.COC[C@H](C)OC1CCNCC1.O=C(O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F>>COC[C@H](C)OC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1",
        "output": "44"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COc1ccc(S(=O)(=O)N(Cc2ccccc2)c2ncc(C(F)(F)F)cc2Cl)cn1.Cl>>O=S(=O)(c1ccc(O)nc1)N(Cc1ccccc1)c1ncc(C(F)(F)F)cc1Cl",
        "output": "408"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1cccc(-n2ccnc2)c1[N+](=O)[O-]>>CCOC(=O)c1cccc(-n2ccnc2)c1N",
        "output": "268"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC1(CO)COCCN1Cc1ccccc1.CCOC(C)=O.CI.O.[H-].[Na+]>>COCC1(C)COCCN1Cc1ccccc1",
        "output": "140"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1.CCN(CC)CC.CN(C)C=O.CN(C)c1ccncc1.O.O=C1NCCCN1CCO>>CC(C)(C)[Si](OCCN1CCCNC1=O)(c1ccccc1)c1ccccc1",
        "output": "602"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "ClCCl.O=C(O)C1CCNCC1.O=C(OC(=O)C(F)(F)F)C(F)(F)F>>O=C(O)C1CCN(C(=O)C(F)(F)F)CC1",
        "output": "397"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCNC1.CC1Cc2ccc(-c3ccnc(C(=O)O)c3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1>>CC1Cc2ccc(-c3ccnc(C(=O)N4CCCC4)c3)cc2CN1c1cc(N2CCN(C)CC2)nc(N)n1",
        "output": "605"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)C(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1ccc(OCc2ccccc2)cc1.CO.Cl.[Na+].[OH-]>>O=C(O)C(Cc1cccc(OC(F)(F)C(F)F)c1)C(O)c1ccc(OCc2ccccc2)cc1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCCCCCCCCCCCCCCCCI.CN(C)C=O.O.OCC(CO)OCc1ccccc1.[H-].[Na+]>>CCCCCCCCCCCCCCCCCCOCC(CO)OCc1ccccc1",
        "output": "307"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CS(=O)(=O)OCC12CC3CC(CC(C3)C1)C2.O.O=C([O-])[O-].Oc1cc(Cl)c(Br)cc1Cl.[K+].[K+]>>Clc1cc(OCC23CC4CC(CC(C4)C2)C3)c(Cl)cc1Br",
        "output": "702"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.NCCCN1CCOCC1.O=[N+]([O-])c1ccc(Cl)c(S(=O)(=O)Cl)c1Cl>>O=[N+]([O-])c1ccc(Cl)c(S(=O)(=O)NCCCN2CCOCC2)c1Cl",
        "output": "43"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.NC(=O)CCl.O=C1CN(S(=O)(=O)c2cc3ccc(Cl)cc3s2)CCN1CC1CCNCC1>>NC(=O)CN1CCC(CN2CCN(S(=O)(=O)c3cc4ccc(Cl)cc4s3)CC2=O)CC1",
        "output": "340"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CN(C)C=O.NCC1CCc2cc(O)ccc2C1.O>>CC(C)(C)OC(=O)NCC1CCc2cc(O)ccc2C1",
        "output": "631"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CO.COC(=O)CCc1ccc(OCc2cccc(-c3ccc(OCCCc4ccccn4)cc3C)c2)cc1.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Na+].[OH-]>>Cc1cc(OCCCc2ccccn2)ccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1nc(C#N)c2nc(-c3cccc(OC)c3)sc2c1O.CO.C[O-].NCC(=O)O.[Na+]>>COc1cccc(-c2nc3c(C#N)nc(C(=O)NCC(=O)O)c(O)c3s2)c1",
        "output": "977"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCOC(=O)c1csc(NC(=O)OC(C)(C)C)n1.O.O.[Li+].[OH-]>>CC(C)(C)OC(=O)Nc1nc(C(=O)O)cs1",
        "output": "171"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OCCOCCOCCOCCOCCOCCOCCN)ccc2-n2c(C)nnc21.CN(C)c1ccncc1.COc1ccc2c(c1)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)O)c1nnc(C)n1-2.ClCCl>>CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OCCOCCOCCOCCOCCOCCOCCNC(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4cc(OC)ccc4-n4c(C)nnc43)ccc2-n2c(C)nnc21",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(CO)c1ccncc1.CI.CN(C)C=O.O.[H-].[Na+]>>COCC(C)(C)c1ccncc1",
        "output": "140"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC1(C)OB(c2cccc(NCCc3ccccc3)c2)OC1(C)C.CNC(=O)c1nc(Br)cnc1N>>CNC(=O)c1nc(-c2cccc(NCCc3ccccc3)c2)cnc1N",
        "output": "937"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(F)cc2F)c(OC)c1.CS(C)=O.O=C([O-])[O-].Oc1ccc(C(F)(F)F)cc1-c1ccnnc1.[K+].[K+]>>COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(Oc3ccc(C(F)(F)F)cc3-c3ccnnc3)cc2F)c(OC)c1",
        "output": "564"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2nc3ccccc3n2Cc2cc(=O)[nH]c3c(F)c(F)ccc23)CC1.CO.Cl.ClCCl>>O=c1cc(Cn2c(C3CCNCC3)nc3ccccc32)c2ccc(F)c(F)c2[nH]1",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1cc(Cl)c(N)nc1N.O=C(CBr)c1ccccc1.[I-].[Na+]>>COC(=O)c1cc(Cl)c(N)n2cc(-c3ccccc3)nc12",
        "output": "508"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCN(c2ccc([N+](=O)[O-])cc2C#N)CC1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>N#Cc1cc([N+](=O)[O-])ccc1N1CCNCC1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COc1cccc(C=O)c1O.O.O=S(=O)(Cl)c1ccccc1.[Na+].[OH-]>>COc1cccc(C=O)c1OS(=O)(=O)c1ccccc1",
        "output": "380"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCC2NCCCC2C1.O=C(O)C1CCCN(S(=O)(=O)c2ccccc2Cl)C1>>O=C(C1CCCN(S(=O)(=O)c2ccccc2Cl)C1)N1CCCC2CCCCC21",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrB(Br)Br.COc1c(F)cc(-c2nn(C(C)c3oc4ccccc4c(=O)c3-c3cccc(F)c3)c3ncnc(N)c23)cc1F.ClCCl>>CC(c1oc2ccccc2c(=O)c1-c1cccc(F)c1)n1nc(-c2cc(F)c(O)c(F)c2)c2c(N)ncnc21",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1ccc(COc2ccc(Oc3c(C)cc(/C=C/C(=O)N4CCN[C@@H](C)C4)cc3Cl)nc2)cc1.ClCCl.O=C([O-])O.O=Cc1ccc(CCOc2ccc(F)cc2)cc1.[Na+].[Na+]>>Cc1ccc(COc2ccc(Oc3c(C)cc(/C=C/C(=O)N4CCN(Cc5ccc(CCOc6ccc(F)cc6)cc5)[C@@H](C)C4)cc3Cl)nc2)cc1",
        "output": "567"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CO.COC(=O)NC(CCS(C)(=O)=O)(Cc1cccc(C#N)c1)C(=O)O.ClCCl.F[P-](F)(F)(F)(F)F.N#Cc1ccc(CNC(=O)CN)s1>>COC(=O)NC(CCS(C)(=O)=O)(Cc1cccc(C#N)c1)C(=O)NCC(=O)NCc1ccc(C#N)s1",
        "output": "133"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N[C@@H](CC(=O)O)Cc1ccc2ccccc2c1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.COCCCn1c([C@@H]2CCCNC2)nc2ccc(Cl)cc21.F[P-](F)(F)(F)(F)F>>COCCCn1c([C@@H]2CCCN(C(=O)C[C@@H](Cc3ccc4ccccc4c3)NC(=O)OC(C)(C)C)C2)nc2ccc(Cl)cc21",
        "output": "146"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)Oc1cc(C(=O)NC2CCN(C)CC2)ccc1[N+](=O)[O-].CO.[H][H].[Pd]>>CC(C)Oc1cc(C(=O)NC2CCN(C)CC2)ccc1N",
        "output": "28"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.COc1c(Cl)nc(Cl)nc1Cl.Cl.OCC1COCCN1>>COc1c(Cl)nc(Cl)nc1N1CCOCC1CO",
        "output": "162"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.O=C(O)c1cc(-c2ccc(F)cc2F)ccc1O.O=S(=O)(O)O>>CCOC(=O)c1cc(-c2ccc(F)cc2F)ccc1O",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)Nc1cccc([N+](=O)[O-])c1.CO.[Pd]>>CC(C)(C)OC(=O)Nc1cccc(N)c1",
        "output": "1"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)C1(NC(=O)OC(C)(C)C)CCN(c2ncnc3[nH]cnc23)CC1.Cl.[Na+].[OH-]>>CC(C)(C)OC(=O)NC1(C(=O)O)CCN(c2ncnc3[nH]cnc23)CC1",
        "output": "88"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CC(C(=O)O)C1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.Nc1cc(Cl)ccc1Br>>CC(C)(C)OC(=O)N1CC(C(=O)Nc2cc(Cl)ccc2Br)C1",
        "output": "365"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.COc1ccc(CC(N)C(O)c2ccc(F)cc2)cc1.O.O=C(Cl)C1CCCCC1.O=C([O-])O.[Na+]>>COc1ccc(CC(NC(=O)C2CCCCC2)C(O)c2ccc(F)cc2)cc1",
        "output": "45"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "Cc1ncccc1Br.ClC(Cl)(Cl)Cl.O=C1CCC(=O)N1Br>>BrCc1ncccc1Br",
        "output": "590"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrCc1ccccc1.C1CCOC1.COCOc1cc(OCOC)c(C(C)C)cc1C(=O)O.NN.O>>COCOc1cc(OCOC)c(C(C)C)cc1C(=O)NN",
        "output": "55"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.CCOC(=O)c1ncc2[nH]c3ccc(C4CC=CCC4)cc3c2c1C.[Ni]>>CCOC(=O)c1ncc2[nH]c3ccc(C4CCCCC4)cc3c2c1C",
        "output": "143"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1(O)CCNCC1.ClCCBr>>CC1(O)CCN(CCCl)CC1",
        "output": "73"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)C(=O)c1cccc(Br)c1.COC(OC)OC.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.OCCO>>CC(C)C1(c2cccc(Br)c2)OCCO1",
        "output": "93"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COc1cc(C(CO)CNC(C)=O)ccc1[N+](=O)[O-].O=[Pt]=O>>COc1cc(C(CO)CNC(C)=O)ccc1N",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COC(=O)c1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2/C=C/c2ccc(-c3ccc(N)cc3)cc2)cc1.O=S(=O)(Cl)CC(F)(F)F>>COC(=O)c1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2/C=C/c2ccc(-c3ccc(NS(=O)(=O)CC(F)(F)F)cc3)cc2)cc1",
        "output": "194"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccccc1CN.Fc1ccc(Oc2cccc3nc(Cl)ccc23)cc1>>COc1ccccc1CNc1ccc2c(Oc3ccc(F)cc3)cccc2n1",
        "output": "612"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Fc1ccc(C(Nc2ccc(F)c(F)c2)C2CCNCC2)cc1.O=S(CCCCl)c1ccc(Cl)cc1>>O=S(CCCN1CCC(C(Nc2ccc(F)c(F)c2)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1",
        "output": "138"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCC2=NCCCN2CC1.CC#N.CCOc1nn(C(=O)Oc2ccccc2)c(=O)n1C1CC1.COc1cccc(I)c1S(N)(=O)=O>>CCOc1nn(C(=O)NS(=O)(=O)c2c(I)cccc2OC)c(=O)n1C1CC1",
        "output": "690"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1n[nH]cc1-c1ccc2c(c1)C(C)NCC2.O=C(O)c1cc2ncc(Br)cn2n1>>Cc1n[nH]cc1-c1ccc2c(c1)C(C)N(C(=O)c1cc3ncc(Br)cn3n1)CC2",
        "output": "952"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.ClCCl.c1cc2[nH]ccc2cn1>>CC(C)(C)OC(=O)n1ccc2cnccc21",
        "output": "748"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)c1cc(C(=O)O)[nH]n1.CN(C)C=O.C[C@H](N)Cn1ccc(-c2ccc(C#N)c(Cl)c2F)n1>>CC(=O)c1cc(C(=O)N[C@@H](C)Cn2ccc(-c3ccc(C#N)c(Cl)c3F)n2)[nH]n1",
        "output": "816"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "N=C(NN)c1ccccn1.O=Cc1ccc(Br)cc1>>Brc1ccc(-c2nc(-c3ccccn3)n[nH]2)cc1",
        "output": "994"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCO1.C[C@]12C[C@H](c3ccc(OCCCCCS(=O)(=O)CCCC(F)(F)C(F)(F)F)cc3)[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O.C[O-].C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-].[Cl-].[NH4+].[Na+]>>C=C1CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3[C@@H](c3ccc(OCCCCCS(=O)(=O)CCCC(F)(F)C(F)(F)F)cc3)C[C@]12C",
        "output": "601"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)O.Cc1cccc(CO[C@@H]2CCC[C@H](OCc3nc(-c4ccc(C(C)C)cc4)oc3C)C2)c1C(=O)[O-].Cl.[K+].[OH-]>>Cc1cccc(CO[C@@H]2CCC[C@H](OCc3nc(-c4ccc(C(C)C)cc4)oc3C)C2)c1C(=O)O",
        "output": "151"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CC2(CCN1)OCCO2.CN(C)C=O.N#Cc1ccccc1F>>N#Cc1ccccc1N1CCC2(CC1)OCCO2",
        "output": "26"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1COCCO1.CCS(=O)(=O)Nc1cccc(B(O)O)c1.Cc1ccc(-c2ccc3c(=O)n(C)cc(Br)c3c2)cn1.Cl[Pd]Cl.O=P([O-])([O-])[O-].[Fe+2].[K+].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCS(=O)(=O)Nc1cccc(-c2cn(C)c(=O)c3ccc(-c4ccc(C)nc4)cc23)c1",
        "output": "833"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)c1cc(-c2cc(Cl)c(OCc3ccc(OC)cc3)c(Cl)c2)n[nH]1.[Na+].[OH-]>>COc1ccc(COc2c(Cl)cc(-c3cc(C(=O)O)[nH]n3)cc2Cl)cc1",
        "output": "152"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)Nc1cccc(-c2cc3nc(Cl)nc(N4CCOCC4)c3s2)c1.CC1(C)OB(c2cnc(N)nc2)OC1(C)C>>CC(=O)Nc1cccc(-c2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)c1",
        "output": "973"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CO.COC(=O)CCc1nc2nc(N3CCC(Oc4ccccc4C(F)(F)F)CC3)sc2c(=O)[nH]1.O=P([O-])(O)O.[K+].[Li+].[OH-]>>O=C(O)CCc1nc2nc(N3CCC(Oc4ccccc4C(F)(F)F)CC3)sc2c(=O)[nH]1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCC(C)O.CCCCCO.CCN(CC)CC.Cc1ccc2sc3cc(C(=O)Cl)ccc3c(=O)c2c1.ClCCl.O.[Cl-]>>CCCCCOC(=O)c1ccc2c(=O)c3cc(C)ccc3sc2c1",
        "output": "51"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1ccccc1N1CCNCC1.ClCCl.O=CCCc1cc(C=Cc2ccccc2)no1.[Na+]>>COc1ccccc1N1CCN(CCCc2cc(C=Cc3ccccc3)no2)CC1",
        "output": "484"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCCOC.Cc1cc(Cl)ccn1.O=C([O-])[O-].OB(O)c1ccc(F)cc1.[Na+].[Na+]>>Cc1cc(-c2ccc(F)cc2)ccn1",
        "output": "947"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1c2ccc(N3CC[C@H](N)C3=O)cc2CCN1C(=O)OC(C)(C)C.O=S(=O)(Cl)c1ccc2cc(Cl)ccc2c1>>CC1c2ccc(N3CC[C@H](NS(=O)(=O)c4ccc5cc(Cl)ccc5c4)C3=O)cc2CCN1C(=O)OC(C)(C)C",
        "output": "596"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CCO.COc1cccc(-c2cccc3c2CC(=O)N3)c1.Cc1[nH]c(C=O)c(C)c1C(=O)N1CCN(C)CC1>>COc1cccc(-c2cccc3c2C(=Cc2[nH]c(C)c(C(=O)N4CCN(C)CC4)c2C)C(=O)N3)c1",
        "output": "440"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN1CCCC1=O.COC(=O)Cc1cccc(C=O)c1.ClCCl.NCc1ccccc1O.[Na+]>>COC(=O)Cc1cccc(CNCc2ccccc2O)c1",
        "output": "683"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.O=C1CCC(=O)N1I.O=c1ccc(Br)c[nH]1>>O=c1[nH]cc(Br)cc1I",
        "output": "783"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)C(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Nc3ccc(CO)cn3)nc12.ClCCl.O=[Mn]=O>>CC(C)(C)C(=O)c1cn(COCC[Si](C)(C)C)c2ncc(Nc3ccc(C=O)cn3)nc12",
        "output": "520"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CCOC(C)=O.Cc1nn(C)c(C(N)=O)c1[N+](=O)[O-].[Pd]>>Cc1nn(C)c(C(N)=O)c1N",
        "output": "628"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)O.CO.C[O-].N#CCc1cc(Cl)nc(N)n1.[Na+]>>COc1cc(CC#N)nc(N)n1",
        "output": "653"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.ClCCl.N#Cc1ccc(O)cc1.O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCC(O)CC1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1ccc(OC2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)cc1",
        "output": "550"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "O=C([O-])[O-].O=C1OCCN1CCCCl.O=[N+]([O-])c1ncc[nH]1.[K+].[K+]>>O=C1OCCN1CCCn1ccnc1[N+](=O)[O-]",
        "output": "611"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CN(C)C(=O)CC1CCOc2ccc(N)cc21.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>CN(C)CCC1CCOc2ccc(N)cc21",
        "output": "112"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1CN(c2ccc([N+](=O)[O-])cc2F)CCN1C.CCO.[Pd]>>CC1CN(c2ccc(N)cc2F)CCN1C",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCCCc1nc2cc(N(C)C(=O)CC)ccc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.O=C(O)C(F)(F)F>>CCCCc1nc2cc(N(C)C(=O)CC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1c2ccccc2C[C@H]1CO.CCN(CC)CC.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)N1c2ccccc2C[C@H]1C=O",
        "output": "610"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.Nc1ccc2c(ccn2C(=O)c2ccccc2)c1.O>>CS(=O)(=O)Nc1ccc2c(ccn2C(=O)c2ccccc2)c1",
        "output": "194"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)CN1C(=O)[C@H](NC(=O)c2cc3cc(Cl)ncc3[nH]2)Cc2ccccc21.[Li+].[OH-]>>O=C(O)CN1C(=O)[C@H](NC(=O)c2cc3cc(Cl)ncc3[nH]2)Cc2ccccc21",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Cc1ccc(S(=O)(=O)Cl)cc1.Cc1cccc(CCO)c1[N+](=O)[O-]>>Cc1ccc(S(=O)(=O)OCCc2cccc(C)c2[N+](=O)[O-])cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COC(=O)c1c(C2CC2)nc2c(C)cc(Cl)cc2c1-c1ccccc1.O.[K+].[OH-]>>Cc1cc(Cl)cc2c(-c3ccccc3)c(C(=O)O)c(C3CC3)nc12",
        "output": "152"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCC(F)CN1CCC(COc2ccc(-c3ccc(C(=O)OC)cc3)cc2)CC1.CO.O.O.[Li]O>>CCC(F)CN1CCC(COc2ccc(-c3ccc(C(=O)O)cc3)cc2)CC1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCO.CCOC(=O)c1cnc2cc(C#N)ccn12.O.[Li+].[OH-]>>N#Cc1ccn2c(C(=O)O)cnc2c1",
        "output": "171"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.COC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)C(C)(C)SC.[Na+].[OH-]>>CSC(C)(C)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc(-c2cc(C(=O)OC(C)(C)C)c(NC(=O)Nc3c(C)cc(C)cc3C)s2)cc1.ClC(Cl)Cl.O=C(O)C(F)(F)F>>COc1ccc(-c2cc(C(=O)O)c(NC(=O)Nc3c(C)cc(C)cc3C)s2)cc1",
        "output": "569"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)=C1C[C@@H](CO)C1(C)C.CCOC(C)=O.CC[C@H](C)C(=O)O.CN(C)C=O.CO.O=C(Cl)C(=O)Cl.c1ccccc1.c1ccncc1>>CC[C@H](C)C(=O)OC[C@@H]1CC(=C(C)C)C1(C)C",
        "output": "17"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)[O-].CC1(C)CC(=O)c2c(C(F)(F)F)nn(-c3ccc(C#N)c(Br)c3)c2C1.CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.COCCOC.N[C@H]1CC[C@H](N)CC1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>CC1(C)CC(=O)c2c(C(F)(F)F)nn(-c3ccc(C#N)c(N[C@@H]4CC[C@@H](N)CC4)c3)c2C1",
        "output": "519"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.CCc1cccc(CN(CC(O)C(Cc2cc(O)cc(F)c2)NC(=O)CN)C(=O)OC(C)(C)C)c1.O=C(Cl)CCCCBr>>CCc1cccc(CN(CC(O)C(Cc2cc(O)cc(F)c2)NC(=O)CNC(=O)CCCCBr)C(=O)OC(C)(C)C)c1",
        "output": "159"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Br.COc1ccc2c(c1)CCC(N1CCN(c3ccccc3C)CC1)C2>>Cc1ccccc1N1CCN(C2CCc3cc(O)ccc3C2)CC1",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCN1.CC(C)(C)O.Clc1ccc2ncc(Br)n2n1.O>>Brc1cnc2ccc(N3CCOCC3)nn12",
        "output": "406"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)c1ccc[nH]c1=O.CN(C)C=O.COc1cc2ccccc2cc1CBr.Cl.[H-].[Na+]>>CCOC(=O)c1cccn(Cc2cc3ccccc3cc2OC)c1=O",
        "output": "528"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)NC(C)C.CN.Cc1cc(S(=O)(=O)Cl)ccc1NC(=O)c1cc(Cl)ncn1>>CNS(=O)(=O)c1ccc(NC(=O)c2cc(Cl)ncn2)c(C)c1",
        "output": "43"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.O=C(O)c1ccc(C(F)(F)F)nc1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1ccc(C(F)(F)F)nc1",
        "output": "293"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)N1C2CCC1CC(CO)(C1CCCCC1)C2.CC(C)NC(C)C.CN(C)c1ccccn1.CS(=O)(=O)Cl.ClCCl>>CC(C)(C)OC(=O)N1C2CCC1CC(COS(C)(=O)=O)(C1CCCCC1)C2",
        "output": "0"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC#N.C[O-].Clc1ccc(Br)c(Cl)n1.O.[Na+]>>COc1nc(Cl)ccc1Br",
        "output": "433"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CO.O=C(O)c1ccc(I)cc1.O=S(=O)(O)O>>COC(=O)c1ccc(I)cc1",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CO.O=C(O)c1ccc(Cl)c(I)c1>>OCc1ccc(Cl)c(I)c1",
        "output": "72"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#CCOc1ccc(C(=O)OC)cc1.CCO.O.[Na+].[OH-]>>C#CCOc1ccc(C(=O)O)cc1",
        "output": "222"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1.CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCCOC(CC)C(=O)O.CCN(CC)CC.CCOC(=O)[C@@H](N)CC(C)C.Cl.Oc1cccc2[nH]nnc12>>CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCCOC(CC)C(=O)N[C@@H](CC(C)C)C(=O)OCC",
        "output": "107"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCCC(CCCBr)C1.CN(C)C=O.OCc1cc(Br)ccc1F.[H-].[I-].[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCCC(CCCOCc2cc(Br)ccc2F)C1",
        "output": "95"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)CC(=O)O.ClCCl.F[P-](F)(F)(F)(F)F.NC(=O)c1ccc(N2CCC[C@@H](N)C2)nc1Nc1ccc(C(=O)N2CCOCC2)cc1>>CN(C)CC(=O)N[C@@H]1CCCN(c2ccc(C(N)=O)c(Nc3ccc(C(=O)N4CCOCC4)cc3)n2)C1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1ccc(F)c2c(C(=O)O)c[nH]c12.NC1CCOCC1>>COc1ccc(F)c2c(C(=O)NC3CCOCC3)c[nH]c12",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=C(C)C(=O)Cl.CCCCCCCCON1C(C)(C)CC(O)CC1(C)C.CCN(CC)CC.ClCCl>>C=C(C)C(=O)OC1CC(C)(C)N(OCCCCCCCC)C(C)(C)C1",
        "output": "320"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cl.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Oc1ccc2c3c(ccc2c1)-c1ccc(Br)cc1CO3.c1ccncc1>>O=S(=O)(Oc1ccc2c3c(ccc2c1)-c1ccc(Br)cc1CO3)C(F)(F)F",
        "output": "731"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)c1cc(C2CC2)c(OC[C@H]2CCCNC2)cc1F.COC(=O)c1cc(C2CC2)c(O[C@@H]2CCCNC2)cc1F.Fc1ccc(CBr)c(C(F)(F)F)c1.Fc1ccc(CBr)c(Cl)c1>>COC(=O)c1cc(C2CC2)c(OC[C@H]2CCCN(Cc3ccc(F)cc3Cl)C2)cc1F",
        "output": "248"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(Cc2nnc3ccc(F)cn23)CC1.CN(C)C=O.N[C@H]1CC[C@@H](O)c2ccccc21.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCC(Cc2nnc3ccc(O[C@@H]4CC[C@H](N)c5ccccc54)cn23)CC1",
        "output": "823"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CCN2C[C@@H](N)C[C@H]2C1.CN(C)C=O.ClCCl.O=C([O-])[O-].O=S(=O)(Cl)c1cccc(C(F)(F)F)c1.[Na+].[Na+]>>CC(C)(C)OC(=O)N1CCN2C[C@@H](NS(=O)(=O)c3cccc(C(F)(F)F)c3)C[C@H]2C1",
        "output": "43"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCN(CCc1ccccn1)C(=O)CCc1ccc(OCc2ccccc2C(=O)OC)cc1.Cl.O.[Li+].[OH-]>>CCN(CCc1ccccn1)C(=O)CCc1ccc(OCc2ccccc2C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCOC(=O)c1nc2ccccn2c1-c1ccc(N2CCN(C)CC2)nc1.CO.[BH4-].[Li+].[Na+].[OH-]>>CN1CCN(c2ccc(-c3c(CO)nc4ccccn34)cn2)CC1",
        "output": "286"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1(c2ccc(N)c([N+](=O)[O-])c2)CCC1.CCO.[Pd]>>CC1(c2ccc(N)c(N)c2)CCC1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)CCC(=O)c1ccc(C#N)cc1.CCOC(C)=O.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.OCCO>>CC(C)(C)CCC1(c2ccc(C#N)cc2)OCCO1",
        "output": "93"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)OC(C)=O.CC(C)(C)[Si](O[C@H]1CC[C@](C)([C@H]2CC[C@]3(C)C(c4ccccc4)=CC[C@H]3[C@@H]2CO)[C@@H](CO)C1)(c1ccccc1)c1ccccc1.CCOC(C)=O.CN(C)c1ccncc1.c1ccncc1>>CC(=O)OC[C@H]1C[C@@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CC[C@]1(C)[C@H]1CC[C@]2(C)C(c3ccccc3)=CC[C@H]2[C@@H]1CO",
        "output": "254"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CC(C)(C)N1CCC(S)CC1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCN(C(C)C)C(C)C.FC(F)(F)c1n[nH]cc1-c1cn2c(n1)-c1cc(Br)ccc1OCC2.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]>>CC(C)(C)N1CCC(Sc2ccc3c(c2)-c2nc(-c4c[nH]nc4C(F)(F)F)cn2CCO3)CC1",
        "output": "824"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCSc1cc2cc[nH]c2cc1Cl.[BH3-]C#N.[Na+]>>CCSc1cc2c(cc1Cl)NCC2",
        "output": "672"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrCCCCCCBr.O.OCCc1cccnc1.[Na+].[OH-]>>BrCCCCCCOCCc1cccnc1",
        "output": "95"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)[C@@H]1C[C@@H]1c1cn(C)c2c(-c3noc(-c4ccc(OC(C)C)c(Cl)c4)n3)cccc12.Cl.[Na+].[OH-]>>CC(C)Oc1ccc(-c2nc(-c3cccc4c([C@H]5C[C@H]5C(=O)O)cn(C)c34)no2)cc1Cl",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCO.CN(C)C=O.COC(=O)c1ccc(Sc2ccc(O)cc2)c([N+](=O)[O-])c1.O.[Cl-].[Fe].[NH4+]>>COC(=O)c1ccc(Sc2ccc(O)cc2)c(N)c1",
        "output": "481"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CI.O=C1CC[C@@H]2c3ccc(Cl)cc3CC[C@H]2N1.[Na+].[OH-]>>CN1C(=O)CC[C@@H]2c3ccc(Cl)cc3CC[C@H]21",
        "output": "83"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "COC(=O)[C@@H](NC(=O)c1cc2ccccc2cc1N)[C@@H](C)OC1CCC1.Cc1cc(C)c(N=C=O)c(C)c1.c1ccncc1>>COC(=O)[C@@H](NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cc(C)cc1C)[C@@H](C)OC1CCC1",
        "output": "993"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1ccc([C@H]2C[C@@]3(C)[C@@H](C=C[C@@]3(O)CC#C[Si](C)(C)C)[C@@H]3CCC4=CC(=O)CCC4=C23)cc1.CO.O.O=C([O-])[O-].[K+].[K+]>>C#CC[C@]1(O)C=C[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(C(C)=O)cc3)C[C@@]21C",
        "output": "337"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)[C@@H](N)CO.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.Cc1ccccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(C(=O)O)cc1.F[P-](F)(F)(F)(F)F>>Cc1ccccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(C(=O)N[C@@H](CO)C(C)C)cc1",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCOCC.ClCCl.O=[Cr](=O)([O-])Cl.O=[N+]([O-])c1ccc(C2SCCCS2)c(CO)c1.c1cc[nH+]cc1>>O=Cc1cc([N+](=O)[O-])ccc1C1SCCCS1",
        "output": "179"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CC(C)(C)OC(=O)N[C@@H]1CCCN(c2c(Cl)cnc3[nH]cc(N)c23)C1.CCN(CC)CC.CN1CCCC1=O.COCC(=O)Cl.O.O.[Li+].[OH-]>>COCC(=O)Nc1c[nH]c2ncc(Cl)c(N3CCC[C@@H](NC(=O)OC(C)(C)C)C3)c12",
        "output": "422"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.CCOC(=O)CCc1ccc(C2=NC(C)(C)Cc3cc(OCC)c4c(c32)CC(C)(C)O4)cc1.Cl.[Na+].[OH-]>>CCOc1cc2c(c3c1OC(C)(C)C3)C(c1ccc(CCC(=O)O)cc1)=NC(C)(C)C2",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "Br.CBr.COc1ccc(P(=O)(c2ccc(C)cc2)c2ccc(OC)cc2)cc1.O=S([O-])[O-].[Br-].[K+].[Na+].[Na+]>>Cc1ccc(P(=O)(c2ccc(O)cc2)c2ccc(O)cc2)cc1",
        "output": "20"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(=O)C12CC1C=CCCCCCC(NC(=O)OC(C)(C)C)C(=O)N1CC(O[Si](C)(C)C(C)(C)C)CC1C(=O)N2.CO.O.[Li+].[OH-]>>CC(C)(C)OC(=O)NC1CCCCCC=CC2CC2(C(=O)O)NC(=O)C2CC(O[Si](C)(C)C(C)(C)C)CN2C1=O",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "COC(=O)c1ccc(OC)c(OC2CCCCC2=O)c1.COCCOC.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-].[H-].[Na+]>>C=C1CCCCC1Oc1cc(C(=O)OC)ccc1OC",
        "output": "601"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl.NC[C@H]1CCCO1.O=C(O)c1ccc(S(=O)(=O)n2cc(C3CCCC3)c3ccccc32)cc1>>O=C(NC[C@H]1CCCO1)c1ccc(S(=O)(=O)n2cc(C3CCCC3)c3ccccc32)cc1",
        "output": "835"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCN1.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.Cc1nc2c3c(c(C(=O)O)cc2n1C)CCC1(Cc2ccccc2C1)N3.F[B-](F)(F)F>>Cc1nc2c3c(c(C(=O)N4CCOCC4)cc2n1C)CCC1(Cc2ccccc2C1)N3",
        "output": "44"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CO.COC(=O)[C@@H](Cc1ccccn1)Nc1cc(-c2ccc(OCc3ccccc3)cc2)ncn1.Cl.O.O.[Li+].[OH-]>>O=C(O)[C@@H](Cc1ccccn1)Nc1cc(-c2ccc(OCc3ccccc3)cc2)ncn1",
        "output": "88"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(C(=O)O)[nH]n1.ClCCl.F[P-](F)(F)(F)(F)F.N#Cc1cc(-c2ncnc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)n2)ccc1O[C@H]1CCNC[C@H]1F>>Cc1cc(C(=O)N2CC[C@H](Oc3ccc(-c4ncnc(Nc5ccc(N6CCN(C7COC7)CC6)cc5)n4)cc3C#N)[C@H](F)C2)[nH]n1",
        "output": "663"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CNC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cc(OCc2ccccc2)ccc1CC(=O)O.F[P-](F)(F)(F)(F)F>>Cc1cc(OCc2ccccc2)ccc1CC(=O)N1CCC1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.CI.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1cccc(F)c1O.[K+].[K+]>>COc1c(F)cccc1[N+](=O)[O-]",
        "output": "62"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)N1CCC(N)CC1.COc1ccc(C[C@H]2NC(=O)n3c2nc2ccccc23)cc1.O=C(O)C(F)(F)F>>COc1ccc(C[C@@H](NC(=O)NC2CCN(C(C)=O)CC2)c2nc3ccccc3[nH]2)cc1",
        "output": "999"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(C(C)(C)C#N)cc1F.Cc1ccccc1.Cl.O.[Al+3].[Ca+2].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]>>CC(C)(C#N)c1ccc(O)c(F)c1",
        "output": "48"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCc1ccccc1.CN(C)C=O.COC(=O)c1ccc2cc[nH]c(=O)c2c1.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1ccc2ccn(Cc3ccccc3)c(=O)c2c1",
        "output": "528"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC1C2CCc3cnc(-c4ccccc4)nc3C2(c2ccccc2)CCC12OCCO2.Cl.O=C([O-])O.[Na+]>>CC1C(=O)CCC2(c3ccccc3)c3nc(-c4ccccc4)ncc3CCC12",
        "output": "251"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.O.O=C1c2cc(Cl)ccc2OCC1n1ccnc1.[BH4-].[Na+]>>OC1c2cc(Cl)ccc2OCC1n1ccnc1",
        "output": "24"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)[O-].CC(C)(C)c1ccc(Br)cc1.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1ccccc1.Cc1nc(CC2CCNCC2)nc(C(=O)OC(C)(C)C)c1OCc1ccccc1.Cl.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd]>>Cc1nc(CC2CCN(c3ccc(C(C)(C)C)cc3)CC2)nc(C(=O)OC(C)(C)C)c1OCc1ccccc1",
        "output": "294"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cncc(B2OC(C)(C)C(C)(C)O2)c1.Cc1nn(C)cc1-n1c(=O)n(C)c2cnc3ccc(Br)cc3c21>>COc1cncc(-c2ccc3ncc4c(c3c2)n(-c2cn(C)nc2C)c(=O)n4C)c1",
        "output": "954"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)O.COc1ccc(-c2ccc(F)cc2C)cc1.I.O>>Cc1cc(F)ccc1-c1ccc(O)cc1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCO.CCOC(=O)C1CCNCC1.Cc1cc(Cl)nc(N)n1>>CCOC(=O)C1CCN(c2cc(C)nc(N)n2)CC1",
        "output": "162"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(O)c1ccc(-c2ccc([C@H]3OC(C)(C)N(C(=O)C(F)F)[C@@H]3CF)cc2)cn1.CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O=C([O-])O>>CC(OS(C)(=O)=O)c1ccc(-c2ccc([C@H]3OC(C)(C)N(C(=O)C(F)F)[C@@H]3CF)cc2)cn1",
        "output": "0"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrB(Br)Br.COc1ccc(CN2CC(C)(C)C(Oc3ccc(C#N)c(C(F)(F)F)c3)C2=O)cc1.ClCCl.O>>CC1(C)CN(Cc2ccc(O)cc2)C(=O)C1Oc1ccc(C#N)c(C(F)(F)F)c1",
        "output": "207"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.NC1CC1.O=C(O)CN1CCN(c2cccc3c2cnn3-c2ccccc2F)C1=O>>O=C(CN1CCN(c2cccc3c2cnn3-c2ccccc2F)C1=O)NC1CC1",
        "output": "230"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12.Cl.O.O.[Li]O>>O=C(O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12",
        "output": "247"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCCC(=O)Nc1nn(COCC[Si](C)(C)C)c2cc(Br)c(Br)cc12.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.[F-]>>CCCC(=O)Nc1n[nH]c2cc(Br)c(Br)cc12",
        "output": "813"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CO.COC(=O)CCSC[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1.[Na+].[OH-]>>O=C(O)CCSC[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1",
        "output": "88"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(CO)(CO)NCc1ccccc1.CC(Cl)C(=O)Cl.CCN(CC)CC.ClCCl>>CC(Cl)C(=O)N(Cc1ccccc1)C(C)(CO)CO",
        "output": "240"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC1(C)CCC(C)(C)c2ccccc21.ClCCl.O=C(Cl)CCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>CC1(C)CCC(C)(C)c2cc(C(=O)CCCl)ccc21",
        "output": "31"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrB(Br)Br.CO.COc1cc(OC)cc(C(=O)[C@H]2[C@H](C)C(C(=O)c3ccccn3)C[C@H]3C(C)(C)CCC[C@]23C)c1.ClCCl>>C[C@@H]1C(C(=O)c2ccccn2)C[C@H]2C(C)(C)CCC[C@]2(C)[C@H]1C(=O)c1cc(O)cc(O)c1",
        "output": "20"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "N[C@@H](Cc1cc(F)cc(F)c1)c1ncncc1-c1cccc2cnccc12.O=C(O)Cn1nc(C(F)F)c2c1C(F)(F)C1CC21>>O=C(Cn1nc(C(F)F)c2c1C(F)(F)C1CC21)N[C@@H](Cc1cc(F)cc(F)c1)c1ncncc1-c1cccc2cnccc12",
        "output": "230"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1.CO.[Na+].[OH-]>>CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)O",
        "output": "186"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CSC(=S)NCCO.ClC(c1ccccc1)(c1ccccc1)c1ccccc1.O.c1ccncc1>>CSC(=S)NCCOC(c1ccccc1)(c1ccccc1)c1ccccc1",
        "output": "250"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrC(Br)(Br)Br.COc1cc(C[C@@H](C)NC(=O)C(F)(F)F)c(OC)cc1CCO.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COc1cc(C[C@@H](C)NC(=O)C(F)(F)F)c(OC)cc1CCBr",
        "output": "378"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Br.COc1ncccc1-c1nc(C2CC(C)(C)OC(C)(C)C2)cn1-c1ccc(Cl)cc1>>CC1(C)CC(c2cn(-c3ccc(Cl)cc3)c(-c3ccc[nH]c3=O)n2)CC(C)(C)O1",
        "output": "758"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.ClCCl.O=C(Cl)OCc1ccccc1.c1ccc(C2CCNC(C3CCCCC3)C2)cc1>>O=C(OCc1ccccc1)N1CCC(c2ccccc2)CC1C1CCCCC1",
        "output": "427"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CCO.CCOC(=O)/C=C/c1ccc(OCCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)cc1Oc1ncc(C(F)(F)F)cc1Cl.Cl.[Na+].[OH-]>>CC(C)(C)[Si](OCCOc1ccc(/C=C/C(=O)O)c(Oc2ncc(C(F)(F)F)cc2Cl)c1)(c1ccccc1)c1ccccc1",
        "output": "122"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(=O)Cc1nc(-c2ccc(F)cc2)oc1-c1cccc(OCc2ccccc2)c1.CO.[C].[Pd]>>CCOC(=O)Cc1nc(-c2ccc(F)cc2)oc1-c1cccc(O)c1",
        "output": "23"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.COc1ccc(F)c([C@H]2S[C@H](CC(=O)O)C(=O)Nc3ccc(Cl)cc32)c1OC.O=S(Cl)Cl>>CCOC(=O)C[C@H]1S[C@H](c2c(F)ccc(OC)c2OC)c2cc(Cl)ccc2NC1=O",
        "output": "17"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C=CCCl.CS(C)=O.Cc1ccc([N+](=O)[O-])c(O)c1.O.[Na+].[OH-]>>C=CCOc1cc(C)ccc1[N+](=O)[O-]",
        "output": "119"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "COc1c(CCl)cccc1Oc1ccccc1C.CS(C)=O.O.[C-]#N.[I-].[K+].[Na+]>>COc1c(CC#N)cccc1Oc1ccccc1C",
        "output": "38"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCN(C(C)C)C(C)C.Cc1ccc(N2CCc3ncnc(Cl)c3C2)c(C#N)c1.Cc1ncc([C@H](N)CO[Si](C)(C)C(C)(C)C)cn1>>Cc1ccc(N2CCc3ncnc(N[C@H](CO[Si](C)(C)C(C)(C)C)c4cnc(C)nc4)c3C2)c(C#N)c1",
        "output": "110"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CO.COC(=O)Cc1ccccc1CCc1nc(Nc2ccc(CNC(=O)OC(C)(C)C)cc2)ncc1C(F)(F)F.O.O.[Li]O>>CC(C)(C)OC(=O)NCc1ccc(Nc2ncc(C(F)(F)F)c(CCc3ccccc3CC(=O)O)n2)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1nc(-c2ccccc2)cn1-c1ccc(CCCl)cc1.CN(C)C=O.O.[N-]=[N+]=[N-].[Na+]>>CCc1nc(-c2ccccc2)cn1-c1ccc(CCN=[N+]=[N-])cc1",
        "output": "243"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)c1ccccc1N1CCCN(CC2COc3ccccc3O2)CC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCc1ccccc1N1CCCN(CC2COc3ccccc3O2)CC1",
        "output": "444"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCO.O=Cc1cccc(OCc2ccccc2)c1.[BH4-].[Ca+2].[Cl-].[Cl-].[Na+]>>OCc1cccc(OCc2ccccc2)c1",
        "output": "356"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)[O-].COC(=O)c1cc2[nH]c(-c3ccc(OCc4ccccc4)cc3N)c(C3CCCCC3)c2s1.O.O=C(Cl)CCl.[Na+]>>COC(=O)c1cc2[nH]c(-c3ccc(OCc4ccccc4)cc3NC(=O)CCl)c(C3CCCCC3)c2s1",
        "output": "9"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)O[Si](C)(C)OC1Cc2ccc(O)c3cccc1c23.CI.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>COc1ccc2c3c(cccc13)C(O[Si](C)(C)OC(C)(C)C)C2",
        "output": "62"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC[SiH](CC)CC.ClCCl.O=C(O)C(F)(F)F.Oc1ccc2c(c1)C(O)CC(c1ccc(F)cc1)O2>>Oc1ccc2c(c1)CCC(c1ccc(F)cc1)O2",
        "output": "447"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C1CNC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cl.O=Cc1ncc[nH]1.[Na+]>>c1c[nH]c(CN2CCC2)n1",
        "output": "944"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CC(C)(N)CCO.CCN(C(C)C)C(C)C.O=S(=O)(Cl)c1ccccc1Br>>CC(C)(CCO)NS(=O)(=O)c1ccccc1Br",
        "output": "43"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NCC1CCN(CCN)C1.CN=C=O.ClCCl>>CNC(=O)NCCN1CCC(CNC(=O)OC(C)(C)C)C1",
        "output": "244"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.CS(=O)(=O)c1cc(Br)c(O)c([N+](=O)[O-])c1>>CS(=O)(=O)c1cc(N)c(O)c(Br)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.O=Cc1c(Cl)cncc1Cl.[BH4-].[Na+]>>OCc1c(Cl)cncc1Cl",
        "output": "356"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.ClCCl.O=C(Cl)Oc1ccc(Cc2ccc(C(F)(F)F)cc2)cc1.c1ccc(CCN2CCNCC2)nc1>>O=C(Oc1ccc(Cc2ccc(C(F)(F)F)cc2)cc1)N1CCN(CCc2ccccn2)CC1",
        "output": "219"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCc1nc2c(CC)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.ClCCl.O=C(O)C(F)(F)F>>CCCc1nc2c(CC)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCS(N)(=O)=O.O=C(O)c1cnn2c(Nc3cccc4[nH]ccc34)c(C(=O)N3CCC(c4ccccc4)CC3)cnc12>>CCS(=O)(=O)NC(=O)c1cnn2c(Nc3cccc4[nH]ccc34)c(C(=O)N3CCC(c4ccccc4)CC3)cnc12",
        "output": "991"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "ClC(Cl)Cl.O=C(OO)c1cccc(Cl)c1.O=S([O-])([O-])=S.Oc1cc(SCC(F)(F)F)c(Cl)cc1Cl.[Na+].[Na+]>>O=S(CC(F)(F)F)c1cc(O)c(Cl)cc1Cl",
        "output": "500"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CCOC(C)=O.Cl[Pd]Cl.O.O=C([O-])[O-].O=Cc1cc(Br)ccn1.OB(O)c1cc(Cl)ccc1O.[K+].[K+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=Cc1cc(-c2cc(Cl)ccc2O)ccn1",
        "output": "872"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.O=C(O)CCc1ccc(SCc2coc(/C=C/c3ccccc3)n2)cc1.O=S(=O)(O)O>>CCOC(=O)CCc1ccc(SCc2coc(/C=C/c3ccccc3)n2)cc1",
        "output": "17"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Cc1ccc(-c2cc(C(=O)N3CCCCC3C3(NC(=O)OC(C)(C)C)CC3)nn2-c2cccnc2)nc1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(-c2cc(C(=O)N3CCCCC3C3(N)CC3)nn2-c2cccnc2)nc1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Brc1ccc(Br)nc1.O=Cc1ccc(B(O)O)cc1>>O=Cc1ccc(-c2ccc(Br)cn2)cc1",
        "output": "869"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.CCN1CCOCC1.CN(C)C=O.Cl.ClCCCl.N#Cc1cc(-c2nc(-c3ccc4c(c3)CCNCC4)no2)ccc1OCC(F)(F)F.O.Oc1cccc2[nH]nnc12>>CC(C)(C)OC(=O)NCC(=O)N1CCc2ccc(-c3noc(-c4ccc(OCC(F)(F)F)c(C#N)c4)n3)cc2CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)OC(=O)Nc1cccc(Br)c1.COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Cc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2].c1cc2ncc3c(n2n1)CCNC3>>CC(C)(C)OC(=O)Nc1cccc(N2CCc3c(cnc4ccnn34)C2)c1",
        "output": "294"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCBr.CCOC(C)=O.CN(C)C=O.O.O=C([O-])[O-].O=c1ccc(-c2cccc(Cl)c2)n[nH]1.[K+].[K+]>>CCn1nc(-c2cccc(Cl)c2)ccc1=O",
        "output": "577"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCOC(=O)Cl.COc1ccc(C(=O)O)cc1-c1c(=O)ccn2nc(Oc3ccc(F)cc3F)ccc12.ClCCl.NC1CC1>>COc1ccc(C(=O)NC2CC2)cc1-c1c(=O)ccn2nc(Oc3ccc(F)cc3F)ccc12",
        "output": "334"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC(=CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)OC(C)(C)C)C2S(=O)C1)Sc1nnc(C)s1.Cc1ccc(S(=O)(=O)O)cc1.O.O=C([O-])O.[Na+]>>CC(=CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(N)C2S(=O)C1)Sc1nnc(C)s1",
        "output": "431"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.NCP(=O)(O)O.O.O=[N+]([O-])c1cc(C(F)(F)F)c(Cl)cc1Cl>>O=[N+]([O-])c1cc(C(F)(F)F)c(Cl)cc1NCP(=O)(O)O",
        "output": "304"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.COC(=O)c1ccc([N+](=O)[O-])cc1-c1ccccc1.O=C[O-].[NH4+].[Pd]>>COC(=O)c1ccc(N)cc1-c1ccccc1",
        "output": "772"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC[SiH](CC)CC.COc1cc(C(=O)c2ccccc2)c(OC)cc1Br.ClCCl.O.O=C(O)C(F)(F)F.[Cl-].[NH4+]>>COc1cc(Cc2ccccc2)c(OC)cc1Br",
        "output": "181"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC.COc1c(-c2ccccc2)cc(C)cc1-c1ccccc1.ClCCl.O>>Cc1cc(-c2ccccc2)c(O)c(-c2ccccc2)c1",
        "output": "48"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.COC(=O)Cc1ccc(CC(=O)O)cc1.O=C(Cl)C(=O)Cl>>COC(=O)Cc1ccc(CC(=O)Cl)cc1",
        "output": "56"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CI.CN(C)C=O.Cc1c([N+](=O)[O-])ccc(F)c1C(=O)O.O.O=C([O-])[O-].[K+].[K+]>>COC(=O)c1c(F)ccc([N+](=O)[O-])c1C",
        "output": "415"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C)CNC1CCOCC1.CCOC(C)=O.O.O=C([O-])O.O=[N+]([O-])c1cnc(Cl)nc1Cl.[K+]>>CCOC(=O)C(C)CN(c1nc(Cl)ncc1[N+](=O)[O-])C1CCOCC1",
        "output": "296"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CI.O.OCc1ccccc1N1CCN(Cc2ccccc2)CC1.[H-].[Na+]>>COCc1ccccc1N1CCN(Cc2ccccc2)CC1",
        "output": "140"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)Cl.CCN(CC)CC.COC(=O)CCCCCC(c1ccccc1)c1c(C)c(O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c(C)c(C)c1O.ClCCl.O>>COC(=O)CCCCCC(c1ccccc1)c1c(C)c(O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c(C)c(C)c1OC(C)=O",
        "output": "111"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)NCCNS(=O)(=O)c1c(Cl)ccc(N)c1O.NC(N)=O.O=C=Nc1ccccc1Br>>CC(C)(C)OC(=O)NCCNS(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2ccccc2Br)c1O",
        "output": "473"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(CCC(=O)O)cc1C.ClCCl.O=S(Cl)Cl>>Cc1ccc(CCC(=O)Cl)cc1C",
        "output": "53"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc(-c2n[nH]c3c(Cl)cccc23)cc1.FC(F)(F)CCI.[Na]>>COc1ccc(-c2nn(CCC(F)(F)F)c3c(Cl)cccc23)cc1",
        "output": "346"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC#N.CCOC(C)=O.NC(=O)CNc1ncccc1[N+](=O)[O-].[Pd]>>NC(=O)CNc1ncccc1N",
        "output": "269"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.ClCCl.O=C(O)C1(c2ccc(F)cc2)CC1.On1nnc2ccccc21.c1cnc2[nH]cc(C34CNCC3C4)c2c1>>O=C(N1CC2CC2(c2c[nH]c3ncccc23)C1)C1(c2ccc(F)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCO.CNc1ccc(C)cc1[N+](=O)[O-].Cl.O.[Fe]>>CNc1ccc(C)cc1N",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cl.NC1CCN(Cc2ccccc2)CC1.O=C1OC(=O)c2cc([N+](=O)[O-])ccc21>>O=C1c2ccc([N+](=O)[O-])cc2C(=O)N1C1CCN(Cc2ccccc2)CC1",
        "output": "341"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)NC(CN)c1ncc(C(F)(F)F)cc1Cl.CCN(CC)CC.CCO.COc1nc(OC)nc([N+]2(C)CCOCC2)n1.O.O=C(O)C(F)(F)F.O=C(O)c1sccc1I.[Cl-]>>CC(=O)NC(CNC(=O)c1sccc1I)c1ncc(C(F)(F)F)cc1Cl",
        "output": "736"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)Nc1cccc(CO)n1.CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl>>CC(C)(C)OC(=O)Nc1cccc(COS(C)(=O)=O)n1",
        "output": "0"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCNC1.Cc1nnc(-c2ccc3occ(-c4ccc(C(=O)O)c(F)c4)c3c2)o1>>Cc1nnc(-c2ccc3occ(-c4ccc(C(=O)N5CCCC5)c(F)c4)c3c2)o1",
        "output": "44"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrCC1CC1.CN(C)C=O.OCc1c(F)cc(O)cc1F.[H-].[Na+]>>OCc1c(F)cc(OCC2CC2)cc1F",
        "output": "75"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)C(C#N)(CCCI)c1cccs1.COCc1cccc(OCCN2CCNCC2)n1>>COCc1cccc(OCCN2CCN(CCCC(C#N)(c3cccs3)C(C)C)CC2)n1",
        "output": "184"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CN(C)CCS.Cl.OCCBr.[Na+].[OH-]>>CN(C)CCSCCO",
        "output": "185"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cc(O[C@H]2CCNC2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1.CS(=O)(=O)Cl>>COc1cc(O[C@H]2CCN(S(C)(=O)=O)C2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1",
        "output": "584"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1cncc2cc[nH]c12.C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CN(C)c1ccncc1>>CC(C)(C)OC(=O)n1ccc2cncc(Br)c21",
        "output": "748"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CCOC(=O)c1sc(Br)c(C#N)c1-c1ccc(Cl)cc1Cl.O.[Na+].[OH-]>>N#Cc1c(Br)sc(C(=O)O)c1-c1ccc(Cl)cc1Cl",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.COC(=O)c1cccc(-c2nc3cc(F)ccc3o2)c1.O.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[OH-]>>OCc1cccc(-c2nc3cc(F)ccc3o2)c1",
        "output": "444"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.Cc1cc(CO)ccc1[N+](=O)[O-].c1c[nH]cn1>>Cc1cc(CO[Si](C)(C)C(C)(C)C)ccc1[N+](=O)[O-]",
        "output": "193"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].ClCCl.OB(O)c1ccc(Cl)c(F)c1.OCCc1ccc(O)c(F)c1.[Cu+2].c1ccncc1>>OCCc1ccc(Oc2ccc(Cl)c(F)c2)c(F)c1",
        "output": "920"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1COCCN1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.COc1cc(OC)c(F)c(N2Cc3cnc4c(cc(CC=O)n4S(=O)(=O)c4ccccc4)c3N(C)C2=O)c1F.ClCCl.[Na+]>>COc1cc(OC)c(F)c(N2Cc3cnc4c(cc(CCN5CCOCC5)n4S(=O)(=O)c4ccccc4)c3N(C)C2=O)c1F",
        "output": "484"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#Cc1ccc(C(C)(C)C)cc1.CC(C)CCC(C)(C)c1ccc(C#C[Si](C)(C)C)cc1>>C#Cc1ccc(C(C)(C)CCC(C)C)cc1",
        "output": "337"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)CCc1ccnc(-c2nc(=O)c3ccc(Cl)cc3s2)c1.O=C(O)C(F)(F)F>>O=C(O)CCc1ccnc(-c2nc(=O)c3ccc(Cl)cc3s2)c1",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COCCOCCl.O=Cc1ccc(O)cc1>>COCCOCOc1ccc(C=O)cc1",
        "output": "375"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "COC(=O)c1nc(C#N)c2c(=O)n(Cc3ccccc3)ccc2c1O.C[O-].NCCC(=O)O.[Na+]>>N#Cc1nc(C(=O)NCCC(=O)O)c(O)c2ccn(Cc3ccccc3)c(=O)c12",
        "output": "487"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.Cc1ccc(F)c(Br)c1.O=Cc1ccnc2ccccc12.[Li]CCCC>>Cc1ccc(F)c(C(O)c2ccnc3ccccc23)c1",
        "output": "379"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)CCN(C)c1nc2ccc(N)cc2s1.O=C(O)c1ccc(C2C=CCCC2)cc1>>CN(C)CCN(C)c1nc2ccc(NC(=O)c3ccc(C4C=CCCC4)cc3)cc2s1",
        "output": "50"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.COC(=O)c1ccc(-c2nc3nccc(-c4cccc(CN5CCOCC5)c4)c3[nH]2)cc1.O>>O=C(O)c1ccc(-c2nc3nccc(-c4cccc(CN5CCOCC5)c4)c3[nH]2)cc1",
        "output": "247"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.COc1ccc(O)c(Cl)c1.CSc1nc(Cl)cc(Cl)n1.O.O=C([O-])[O-].[K+].[K+]>>COc1ccc(Oc2cc(Cl)nc(SC)n2)c(Cl)c1",
        "output": "668"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC[N+](CC)(CC)Cc1ccccc1.Cc1cc([N+](=O)[O-])c(O)nc1C.O=P(Cl)(Cl)Cl.[Cl-]>>Cc1cc([N+](=O)[O-])c(Cl)nc1C",
        "output": "41"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCC.CCOC(C)=O.CN(C)C=O.CN(C)c1ccncc1.ClCCl.N#CCCBr.O=C(Nc1ccc2c(c1)CCNC2)c1ccccc1-c1ccc(C(F)(F)F)cc1>>N#CCCN1CCc2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc2C1",
        "output": "722"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCCc1cc(C)[nH]c(=O)c1CN.CN(C)C=O.CN1CCOCC1.Cc1c(CN(C)C)n(C(C)C)c2cc(Cl)cc(C(=O)O)c12.Cl.ClCCCl.ClCCl.On1nnc2cccnc21>>CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(Cl)cc2c1c(C)c(CN(C)C)n2C(C)C",
        "output": "334"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CCN1CCCc2[nH]c(C=O)c(C)c2C1=O.Cc1cccc2c1CC(=O)N2>>CCN(CC)CCN1CCCc2[nH]c(C=C3C(=O)Nc4cccc(C)c43)c(C)c2C1=O",
        "output": "440"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.COC(=O)c1ccc(CSc2ccccc2)cc1.O.O.O.O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>OCc1ccc(CSc2ccccc2)cc1",
        "output": "444"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCc1ccc(C(=O)O)cc1[N+](=O)[O-].CO.O=S(Cl)Cl>>CCc1ccc(C(=O)OC)cc1[N+](=O)[O-]",
        "output": "33"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(C)=O.O=C(O)C=Cc1ccc(O)cc1.[Pd]>>O=C(O)CCc1ccc(O)cc1",
        "output": "344"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOc1cc(C(=O)O)cc(OCC)c1-c1ccc(C(=O)OC)c(F)c1.Cl.Cn1cc(-c2ccc3c(c2)C(=O)CC2(CCNCC2)O3)cn1>>CCOc1cc(C(=O)N2CCC3(CC2)CC(=O)c2cc(-c4cnn(C)c4)ccc2O3)cc(OCC)c1-c1ccc(C(=O)OC)c(F)c1",
        "output": "44"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CC=C(c2ncccc2C#N)CC1.ClCCl.O=C(O)C(F)(F)F>>N#Cc1cccnc1C1=CCNCC1",
        "output": "800"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2[nH]c(=O)cnc2c1.c1ccc2c(c1)C[C@@H]1NCCC[C@H]21>>O=C(c1ccc2[nH]c(=O)cnc2c1)N1CCC[C@@H]2c3ccccc3C[C@@H]21",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1(c2cccnc2)CO1.CN(C)C=O.Cc1ccc2[nH]c3c(c2c1)C(CO)N(C)CC3.Cc1ccc2[nH]c3c(c2c1)CN(C)C(CO)C3.[H-].[Na+]>>Cc1ccc2c(c1)c1c(n2CC(C)(O)c2cccnc2)CCN(C)C1CO",
        "output": "749"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CO.COC(=O)COc1ccc(-c2ccc3c(c2)c(Cc2ccccc2)c(-c2ccccc2)n3C)cc1.[K+].[OH-]>>Cn1c(-c2ccccc2)c(Cc2ccccc2)c2cc(-c3ccc(OCC(=O)O)cc3)ccc21",
        "output": "88"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CS(=O)(=O)O.F[P-](F)(F)(F)(F)F.NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O.O.O=C(O)C(F)(F)c1cccc(Cl)c1>>O=C1CCC(N2Cc3cc(CNC(=O)C(F)(F)c4cccc(Cl)c4)ccc3C2=O)C(=O)N1",
        "output": "599"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CN1CCCC1=O.Fc1cc(Cl)cc(Br)c1.O.O=C([O-])[O-].Oc1cc(F)ccc1Cl.[K+].[K+]>>Fc1ccc(Cl)c(Oc2cc(Cl)cc(Br)c2)c1",
        "output": "564"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.COc1nc(Cl)nc(NC(=O)NS(=O)(=O)c2ccccc2OC(F)F)n1.O.O=C([O-])[O-].OCC(F)(F)F.[K+].[K+]>>COc1nc(NC(=O)NS(=O)(=O)c2ccccc2OC(F)F)nc(OCC(F)(F)F)n1",
        "output": "213"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Cc1cc(C)c(CN)c(=O)[nH]1.O=C(O)c1cc(Cl)cc2c1cnn2C1CCCC1>>Cc1cc(C)c(CNC(=O)c2cc(Cl)cc3c2cnn3C2CCCC2)c(=O)[nH]1",
        "output": "334"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccc(N(c2nc(-c3ccccc3)nc(-c3ccccc3)n2)c2nc(-c3ccccc3)nc(-c3ccccc3)n2)cc1.C1COCCO1.CC(=O)[O-].CC(=O)[O-].Cc1ccccc1.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.O.O=P([O-])([O-])[O-].OB(O)c1ccccc1.[K+].[K+].[K+].[Pd+2]>>c1ccc(-c2ccc(N(c3nc(-c4ccccc4)nc(-c4ccccc4)n3)c3nc(-c4ccccc4)nc(-c4ccccc4)n3)cc2)cc1",
        "output": "837"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)c1ccc(N)cc1.O=Cc1ccc(OC(F)F)cc1>>CC(C)c1ccc(NCc2ccc(OC(F)F)cc2)cc1",
        "output": "359"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1ccc(S(=O)(=O)n2cc(CN3CCCC4(CCN(C(=O)OC(C)(C)C)CC4)C3=O)c3ccccc32)cc1.ClCCl.O=C(O)C(F)(F)F>>Cc1ccc(S(=O)(=O)n2cc(CN3CCCC4(CCNCC4)C3=O)c3ccccc32)cc1",
        "output": "575"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.COC(=O)Cc1cc([N+](=O)[O-])cc(C)c1Br.O.[Fe]>>COC(=O)Cc1cc(N)cc(C)c1Br",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCC(CC)c1nn(-c2ccc(Br)cn2)cc1CCCO.CCCCP(CCCC)CCCC.COC(=O)Cc1cccc(C)c1O.O=C(N=NC(=O)N1CCCCC1)N1CCCCC1>>CCC(CC)c1nn(-c2ccc(Br)cn2)cc1CCCOc1c(C)cccc1CC(=O)OC",
        "output": "478"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.Nc1ccc(F)cc1N.O.O=C(O)CCCCCCCNC(=O)c1cccc(C=C2C(=O)Nc3ccc(F)cc32)c1.Oc1cccc2[nH]nnc12.[Cl-].[Na+]>>Nc1cc(F)ccc1NC(=O)CCCCCCCNC(=O)c1cccc(C=C2C(=O)Nc3ccc(F)cc32)c1",
        "output": "365"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CO.Cl.NC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12.O=CCCOCCOCCc1cccc2ccccc12.[BH3-]C#N.[Na+]>>O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCOCCc3cccc4ccccc34)c2s1",
        "output": "426"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(O)C(=O)O.COc1cccc(N)c1N.Cl.[NH4+].[OH-]>>COc1cccc2nc(C(C)O)[nH]c12",
        "output": "512"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C#CCCCCO.CCN(CC)CC.CCOC(C)=O.COc1cc(Br)ccc1-n1cnc(C)n1.Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[Cu]I>>COc1cc(C#CCCCCO)ccc1-n1cnc(C)n1",
        "output": "659"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrCCCCBr.CN(C)C=O.OCCOCCOCCOCc1ccccc1.[H-].[Na+]>>BrCCCCOCCOCCOCCOCc1ccccc1",
        "output": "95"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC1(C)Oc2ccccc2CC1CCO.Cc1ccc(S(=O)(=O)Cl)cc1.c1ccncc1>>Cc1ccc(S(=O)(=O)OCCC2Cc3ccccc3OC2(C)C)cc1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CCCCCC.COCCCCl.Cc1cc(O)cc(C)c1Br.[H-].[Na+].[Na+].[OH-]>>COCCCOc1cc(C)c(Br)c(C)c1",
        "output": "74"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)O)cn2)c1O.NCCCO>>Cc1cc(C#N)ccc1-c1cnn(-c2ccc(C(=O)NCCCO)cn2)c1O",
        "output": "674"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCCCCCCOc1ccc(OCc2ccccc2)cc1.CC(C)N>>CC(C)NCCCCCCOc1ccc(OCc2ccccc2)cc1",
        "output": "147"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCO.Cc1cc(C)c(Oc2nc(NC(C)(C)C)ccc2C(=O)NS(=O)(=O)c2cccc([N+](=O)[O-])n2)c(C)c1.Cl.O.[Fe]>>Cc1cc(C)c(Oc2nc(NC(C)(C)C)ccc2C(=O)NS(=O)(=O)c2cccc(N)n2)c(C)c1",
        "output": "457"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.CCOC(=O)c1cc(C)c(NC(=O)c2nc(N3CCC(O[Si](C)(C)C(C)(C)C)CC3)ccc2C)c(C)c1.[F-]>>CCOC(=O)c1cc(C)c(NC(=O)c2nc(N3CCC(O)CC3)ccc2C)c(C)c1",
        "output": "708"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1CCC[C@H]1c1nc(-c2ccccc2)no1.ClCCl.O=C(O)C(F)(F)F>>c1ccc(-c2noc([C@@H]3CCCN3)n2)cc1",
        "output": "575"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCc1ccccc1Br.CCOC(C)=O.CN(C)C=O.O.O=C(Nc1c(F)cccc1F)c1cc[nH]n1.O=C([O-])[O-].[K+].[K+]>>O=C(Nc1c(F)cccc1F)c1ccn(Cc2ccccc2Br)n1",
        "output": "635"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)NCC(=O)O.CCN(CC)CC.CN(C)C=O.Nc1ccc(C(=O)O)cc1O>>CC(C)(C)OC(=O)NCC(=O)Nc1ccc(C(=O)O)cc1O",
        "output": "365"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.O=C(OCc1ccccc1)N1CCN(CCc2ccc3c(c2)OCCO3)CC1.[Pd]>>c1cc2c(cc1CCN1CCNCC1)OCCO2",
        "output": "428"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCO.CCN(CC)CC.NCC1COc2ccccc2O1.Nc1nc(Cl)cc(-c2cccc(Cl)c2Cl)n1>>Nc1nc(NCC2COc3ccccc3O2)cc(-c2cccc(Cl)c2Cl)n1",
        "output": "110"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C[C@]1(c2cccc(N)c2)N=C(N)OCC1(F)F.O=C(O)c1ccc(Cl)cn1>>C[C@]1(c2cccc(NC(=O)c3ccc(Cl)cn3)c2)N=C(N)OCC1(F)F",
        "output": "985"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCc1c(OCc2ccc(C(=O)OC)cc2)ccc(C(C)=O)c1O.CO.Cl.O.O.[Li]O>>CCCc1c(OCc2ccc(C(=O)O)cc2)ccc(C(C)=O)c1O",
        "output": "247"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)Cc1ccc(-n2cnc3cccnc32)cc1Cl.Cl.[Li+].[OH-]>>O=C(O)Cc1ccc(-n2cnc3cccnc32)cc1Cl",
        "output": "7"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC1NCCc2cc(-c3ccc(F)nc3)ccc21.O=C(O)c1cc2ncc(Cl)cn2n1>>CC1c2ccc(-c3ccc(F)nc3)cc2CCN1C(=O)c1cc2ncc(Cl)cn2n1",
        "output": "952"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN(C)C=O.C[Si](C)(C)CCOCn1nc(-c2cn[nH]c2)c2ccc(Br)cc21.ClCCN1CCCC1.[H-].[Na+]>>C[Si](C)(C)CCOCn1nc(-c2cnn(CCN3CCCC3)c2)c2ccc(Br)cc21",
        "output": "604"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.CC(=O)c1ccc(C#N)cc1>>N#Cc1ccc(C(=O)CBr)cc1",
        "output": "173"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)CC1CCN(C(=O)CCC2OC(c3cccc(OC)c3OC)c3cc(Cl)ccc3-n3ccnc32)CC1.CO.Cl.ClC(Cl)Cl.O.O=C([O-])[O-].[K+].[K+]>>COc1cccc(C2OC(CCC(=O)N3CCC(CC(=O)O)CC3)c3nccn3-c3ccc(Cl)cc32)c1OC",
        "output": "7"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CO.COCC(C)(CO)NC(=O)C(Oc1cc(C)c2ncc(C#C[Si](C)(C)C)cc2c1)SC.O=C([O-])[O-].[K+].[K+]>>C#Cc1cnc2c(C)cc(OC(SC)C(=O)NC(C)(CO)COC)cc2c1",
        "output": "337"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=Cc1ccc(C=C)cc1.C=Cc1ccccc1.CCN(CC)Cc1ccccc1.CO.ClCCl.N#Cc1ccc(C(=O)Cl)cc1.Nc1ccc2c(c1)CCN(C1CCC1)CC2>>N#Cc1ccc(C(=O)Nc2ccc3c(c2)CCN(C2CCC2)CC3)cc1",
        "output": "11"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Br.COc1ccc(C(=O)c2ccc(OCCCl)cc2)cc1F.O=C([O-])[O-].[Na+].[Na+]>>O=C(c1ccc(OCCCl)cc1)c1ccc(O)c(F)c1",
        "output": "48"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCC2=NCCCN2CC1.C1CCOC1.CC(C)Oc1cc(CCS(N)(=O)=O)n(Cc2ccc(Cl)cc2Cl)n1.CCCCCC(=O)O>>CCCCCC(=O)NS(=O)(=O)CCc1cc(OC(C)C)nn1Cc1ccc(Cl)cc1Cl",
        "output": "644"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)c1c(C)nc(SCc2c(F)ccc(F)c2F)n1-c1ccc(F)cc1.CO.O=C(O)c1cnc(SCc2c(F)ccc(F)c2F)n1-c1ccc(F)cc1.[Li+].[OH-]>>Cc1nc(SCc2c(F)ccc(F)c2F)n(-c2ccc(F)cc2)c1C(=O)O",
        "output": "171"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)O.CN1C(=O)C(F)(F)CN(C2CCCC2)c2nc(Cl)ncc21.COc1cc(C(=O)O)ccc1N.Cl>>COc1cc(C(=O)O)ccc1Nc1ncc2c(n1)N(C1CCCC1)CC(F)(F)C(=O)N2C",
        "output": "808"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CO.O=C(O)c1ccc(NCCO)c([N+](=O)[O-])c1.[Pd]>>Nc1cc(C(=O)O)ccc1NCCO",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)=O.CSc1ccc(C2=C(c3ccc(F)cc3)C(=O)OC2)c(F)c1.O.O=S([O-])OO.[K+]>>CS(=O)(=O)c1ccc(C2=C(c3ccc(F)cc3)C(=O)OC2)c(F)c1",
        "output": "730"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1ccccc1.Nc1ccncc1.O=C=Nc1ccc(Cl)cc1Cl>>O=C(Nc1ccncc1)Nc1ccc(Cl)cc1Cl",
        "output": "473"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COC(=O)c1c(O)c2ncc(Cc3ccc(F)cc3C(F)(F)F)cc2[nH]c1=O.NCCO>>O=C(NCCO)c1c(O)c2ncc(Cc3ccc(F)cc3C(F)(F)F)cc2[nH]c1=O",
        "output": "862"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCOC(C)=O.CCOc1cc(C(=O)N2CC(OC)C2)ccc1[N+](=O)[O-].[Pd]>>CCOc1cc(C(=O)N2CC(OC)C2)ccc1N",
        "output": "28"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COC(=O)CCC=C(C)CCCC(C)CCCC(C)C.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>>CC(=CCCCO)CCCC(C)CCCC(C)C",
        "output": "343"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCOC(=O)CCCn1ncc2cc(-c3noc(-c4cnc(OC(C)C)c(Cl)c4)n3)c(F)cc21.CO.[Na+].[OH-]>>CC(C)Oc1ncc(-c2nc(-c3cc4cnn(CCCC(=O)O)c4cc3F)no2)cc1Cl",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OCc1cccc2cccnc12.CO.[Na+].[OH-]>>OCc1cccc2cccnc12",
        "output": "497"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCCC(C(=O)OC)c1c(C)nc(-c2ccccc2O)nc1-c1ccc(C)cc1.CO.[Na+].[OH-]>>CCCC(C(=O)O)c1c(C)nc(-c2ccccc2O)nc1-c1ccc(C)cc1",
        "output": "88"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.CCCc1c[nH]c2cc(O)ccc12.Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CCO.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCc1c[nH]c2cc(OCCc3sc(-c4ccc(C(F)(F)F)cc4)nc3C)ccc12",
        "output": "478"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "Nc1c(F)cccc1Cl.O=c1[nH]c2nccc(Cl)c2c2ccccc12>>O=c1[nH]c2nccc(Nc3c(F)cccc3Cl)c2c2ccccc12",
        "output": "922"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1COCCO1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCOc1ccc(Br)cc1CC(=O)OC.Cl[Pd]Cl.[Fe+2].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CCOc1ccc(B2OC(C)(C)C(C)(C)O2)cc1CC(=O)OC",
        "output": "942"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.CC(C)(C)OC(=O)NCCCCCC(=O)O.Nc1nc(-c2ccccc2)cs1.O.O=P(Cl)(Cl)Cl.c1ccncc1>>CC(C)(C)OC(=O)NCCCCCC(=O)Nc1nc(-c2ccccc2)cs1",
        "output": "681"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)n1c(Cl)nc2cc(Cl)c([N+](=O)[O-])cc21.CCOC(C)=O.CN1CCNCC1.Cc1ccccc1>>CC(C)n1c(N2CCN(C)CC2)nc2cc(Cl)c([N+](=O)[O-])cc21",
        "output": "36"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCCC(OC)C3)C(C)C(O[Si](C)(C)C(C)(C)C)CC1=O)C(C)CC2OC.CC#N.F.O=C([O-])O.[Na+]>>C=CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCCC(OC)C3)C(C)C(O)CC1=O)C(C)CC2OC",
        "output": "708"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cl[Sn]Cl.Nc1cc(F)c(Br)cc1[N+](=O)[O-].O.O.O.O=C([O-])O.[Na+]>>Nc1cc(F)c(Br)cc1N",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.COC(=O)c1cc(OCC2COC(C)(C)O2)cc(-c2ccc(C)cc2C#N)c1.Cl.[Li+].[OH-]>>Cc1ccc(-c2cc(OCC3COC(C)(C)O3)cc(C(=O)O)c2)c(C#N)c1",
        "output": "247"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CNCCN1.CCOC(=O)c1cn(CC)c2cc(Cl)c(F)cc2c1=O.Cc1ccccc1.c1ccncc1>>CCOC(=O)c1cn(CC)c2cc(N3CCNCC3)c(F)cc2c1=O",
        "output": "280"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(=O)/N=N/C(=O)OCC.CCOC(=O)c1nc(-c2ccc(Cl)cc2Cl)n(-c2ccc(O)cc2)c1C.Cc1ccccc1.OCCCF.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCOC(=O)c1nc(-c2ccc(Cl)cc2Cl)n(-c2ccc(OCCCF)cc2)c1C",
        "output": "478"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)Nc1ccc(C(F)(F)F)cc1NC(=O)CC(=O)c1cccc(-c2ccncc2)c1.ClCCl.O=C(O)C(F)(F)F>>O=C1CC(c2cccc(-c3ccncc3)c2)=Nc2ccc(C(F)(F)F)cc2N1",
        "output": "930"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CNCCNC1.CC#N.ClCCl.O.O=C([O-])[O-].O=[N+]([O-])c1cc(F)ccc1S(=O)(=O)c1cccc(F)c1.[K+].[K+]>>O=[N+]([O-])c1cc(N2CCCNCC2)ccc1S(=O)(=O)c1cccc(F)c1",
        "output": "26"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC2CN(c3cc(Cl)ccc3CN3CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC3)CC2C1.ClCCl.O=C(O)C(F)(F)F>>O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(Cl)cc2N2CC3CNCC3C2)CC1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(C)=O.Cl[Sn]Cl.N.N#Cc1cc([N+](=O)[O-])ccc1NC(=O)c1ccccc1>>N#Cc1cc(N)ccc1NC(=O)c1ccccc1",
        "output": "1"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)NS(=O)(=O)c1cc(N)cc(CCc2cccc(NC(=O)OC(C)(C)C)c2)c1.Clc1ncc(Cl)c(Cl)n1>>CC(C)(C)NS(=O)(=O)c1cc(CCc2cccc(NC(=O)OC(C)(C)C)c2)cc(Nc2nc(Cl)ncc2Cl)c1",
        "output": "352"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(OCC)cc(-c3ccc4c(c3)OC(F)(F)O4)c2)c1CCC(=O)OCC.[Na+].[OH-]>>CCOc1cc(OCCCCCCc2cccc(OCCCC(=O)O)c2CCC(=O)O)cc(-c2ccc3c(c2)OC(F)(F)O3)c1",
        "output": "255"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.COc1ccc(-c2cc(CCCOS(C)(=O)=O)c(=O)n(CC3CC3)n2)cc1F>>COc1ccc(-c2cc(CCCN3CCN(C(=O)OC(C)(C)C)CC3)c(=O)n(CC3CC3)n2)cc1F",
        "output": "496"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "Brc1ccc(-c2ccccc2)cc1.C1COCCO1.CCOC(=O)c1ccc[nH]c1=O.CNCCNC.Cl.O=P([O-])([O-])[O-].[Cu]I.[K+].[K+].[K+]>>CCOC(=O)c1cccn(-c2ccc(-c3ccccc3)cc2)c1=O",
        "output": "349"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "COc1ccc(CNN)cc1.COc1ccc(Cn2ncc(C(N)=O)c2N)cc1.COc1ccc(Cn2ncc3c(=O)n4c(nc32)CNCC4)cc1.NC(=O)c1cnn(-c2ccccc2)c1N.O=C(O)C(F)(F)F>>O=c1c2cn[nH]c2nc2n1CCNC2",
        "output": "978"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CO.COC(=O)C(Cc1ccc(OCc2nc3ccc(Sc4cc(C(C)(C)C)c(O)c(C(C)(C)C)c4)cc3n2C)cc1)OCc1ccc(F)cc1.[Na+].[OH-]>>Cn1c(COc2ccc(CC(OCc3ccc(F)cc3)C(=O)O)cc2)nc2ccc(Sc3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)cc21",
        "output": "88"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCOCCOCCOCCO1.CN(C)C=O.COc1ccc(CO)cc1.COc1ccc2c(Cl)cc(Cl)nc2c1Cl.O.[H-].[Na+]>>COc1ccc(COc2cc(Cl)nc3c(Cl)c(OC)ccc23)cc1",
        "output": "651"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CSc1ccccc1B(O)O.Cc1c(Cl)nc2cc(F)cc(F)c2c1Cl>>CSc1ccccc1-c1nc2cc(F)cc(F)c2c(Cl)c1C",
        "output": "865"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)O.CNC(=O)Cn1cc(N)cn1.Cl.OC[C@@H](Nc1nc(Cl)ncc1Cl)c1ccccc1>>CNC(=O)Cn1cc(Nc2ncc(Cl)c(N[C@H](CO)c3ccccc3)n2)cn1",
        "output": "992"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCC(N2CCNCC2)CC1.C1CCC2=NCCCN2CC1.CC(C)COC(=O)Cl.CO.ClC(Cl)Cl.O=C(O)CCCOc1ccc2[nH]c(=O)ccc2c1>>O=C(CCCOc1ccc2[nH]c(=O)ccc2c1)N1CCN(C2CCCCC2)CC1",
        "output": "146"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(F)c2c(C(=O)O)c[nH]c12.NC1CCOCC1>>Cc1ccc(F)c2c(C(=O)NC3CCOCC3)c[nH]c12",
        "output": "674"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.O.O=Cc1ccc(Br)cc1.OCCO>>Brc1ccc(C2OCCO2)cc1",
        "output": "117"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)C(=O)c1ccc(Nc2ncc([N+](=O)[O-])c(NC)n2)cc1.[Pd]>>CCN(CC)C(=O)c1ccc(Nc2ncc(N)c(NC)n2)cc1",
        "output": "660"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C=CCCC=O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)C(C)(C)Sc1ccc2c(c1)CC(N)C2.ClCCCl.ClCCl.[Na+]>>C=CCCCNC1Cc2ccc(SC(C)(C)C(=O)OC(C)(C)C)cc2C1",
        "output": "426"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrC(Br)(Br)Br.ClCCl.O=[N+]([O-])c1ccc(CO)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=[N+]([O-])c1ccc(CBr)cc1",
        "output": "750"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN1CCCC1=O.Cc1nccc(Cl)n1.Cl.Cl.O.c1ccc(C2CCCc3sc(NC4CCNCC4)nc32)cc1>>Cc1nccc(N2CCC(Nc3nc4c(s3)CCCC4c3ccccc3)CC2)n1",
        "output": "162"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(Cc1ccccc1F)C(=O)COc1ccc(CCSc2ccccc2C(=O)OC)cc1.O.[Li+].[OH-]>>CCN(Cc1ccccc1F)C(=O)COc1ccc(CCSc2ccccc2C(=O)O)cc1",
        "output": "247"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CCOC(C)=O.Cc1ccc(N2CCNCC2)c(C2CC2)c1.Cl.O=C(Cl)c1ccc(I)cc1.[Na+].[OH-]>>Cc1ccc(N2CCN(C(=O)c3ccc(I)cc3)CC2)c(C2CC2)c1",
        "output": "201"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.CN(C)C=O.ClC(Cl)Cl.O.O=C(O)c1ccccc1Sc1ccccc1.O=S(Cl)Cl>>CCOC(=O)c1ccccc1Sc1ccccc1",
        "output": "33"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.C[O-].O=[N+]([O-])c1c(F)cc(F)c(Br)c1F.[Na+]>>COc1cc(F)c([N+](=O)[O-])c(F)c1Br",
        "output": "485"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.Cc1nc(N=C(N)N)sc1-c1ccc(N)cc1.ClCCl.O=CC1CCN(C(=O)OCc2ccccc2)CC1.[Na+]>>Cc1nc(N=C(N)N)sc1-c1ccc(NCC2CCN(C(=O)OCc3ccccc3)CC2)cc1",
        "output": "336"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=C(C(=O)OC(c1ccccc1)c1ccccc1)c1c(F)c(F)c(C(=O)OC)c(F)c1F.CCCCCC.COc1ccccc1.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>C=C(C(=O)O)c1c(F)c(F)c(C(=O)OC)c(F)c1F",
        "output": "228"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C1CCN(c2ccc(F)cc2)CC1.CO.Cl.[K+].[OH-]>>O=C(O)C1CCN(c2ccc(F)cc2)CC1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.CCOC(=O)c1ncn2c1c(Cl)nc1cc(C(F)(F)F)ccc12.ClC(Cl)Cl.N>>CCOC(=O)c1ncn2c1c(N)nc1cc(C(F)(F)F)ccc12",
        "output": "682"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(=O)CC(C)(C)C(=O)c1ccc(OCc2ccccc2)cc1.CO.[Pd]>>CCOC(=O)CC(C)(C)C(=O)c1ccc(O)cc1",
        "output": "23"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)O.Clc1ccc(N2CCNCC2)cc1.F[P-](F)(F)(F)(F)F>>Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(Cl)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CO.COC(=O)c1ccc(Cl)nc1Nc1ccc(Br)cc1F.C[O-].[Na+]>>COC(=O)c1ccc(OC)nc1Nc1ccc(Br)cc1F",
        "output": "433"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)NCCC(=O)Nc1cc(F)ccc1-c1ccc(C(=O)NS(=O)(=O)c2ccc(NCC34CC5CC(CC(C5)C3)C4)c([N+](=O)[O-])c2)cc1.Cl.ClCCl>>NCCC(=O)Nc1cc(F)ccc1-c1ccc(C(=O)NS(=O)(=O)c2ccc(NCC34CC5CC(CC(C5)C3)C4)c([N+](=O)[O-])c2)cc1",
        "output": "538"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)c1ccc2nc(SC)sc2c1.CCOC(=O)c1cnc2nc(SC)sc2c1>>CSc1nc2ncc(CO)cc2s1",
        "output": "383"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)O.CCN(C(C)C)C(C)C.COc1ccc2nc(Nc3cc(C(F)(F)c4ccc(F)cc4)nc(Cl)n3)sc2n1.N[C@H]1CC[C@H](O)CC1>>COc1ccc2nc(Nc3cc(C(F)(F)c4ccc(F)cc4)nc(N[C@@H]4CC[C@@H](O)CC4)n3)sc2n1",
        "output": "544"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.COc1ccc(S(N)(=O)=O)cc1C(O)CN=[N+]=[N-].[Pd]>>COc1ccc(S(N)(=O)=O)cc1C(O)CN",
        "output": "89"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.N.O=C(Nc1ccc(Cl)cn1)c1cc(Cl)ccc1[N+](=O)[O-]>>Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1",
        "output": "486"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CCOC(=O)CCNCc1c(C(=O)OCC)nn(-c2ccccc2Cl)c1-c1ccc(C(F)(F)F)cc1.ClCCl>>CCOC(=O)CCN(Cc1c(C(=O)OCC)nn(-c2ccccc2Cl)c1-c1ccc(C(F)(F)F)cc1)C(=O)OC(C)(C)C",
        "output": "694"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrCc1ccccc1.CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(=O)O.CN(C)C=O.O.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(=O)OCc1ccccc1",
        "output": "403"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CON.Cc1cn(-c2ncccc2C(=O)NC(Cc2ccccc2)C(O)C(=O)O)nc1-c1ccccc1.Cl>>CONC(=O)C(O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1cc(C)c(-c2ccccc2)n1",
        "output": "480"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CNCc1coc(C(C)C)n1.COC(=O)[C@H](C)NC(=O)Oc1ccc([N+](=O)[O-])cc1>>COC(=O)[C@H](C)NC(=O)N(C)Cc1coc(C(C)C)n1",
        "output": "770"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)C1=C(c2ccccc2F)CCC1.O.O=S(=O)([O-])[O-].[Al+3].[H-].[H-].[H-].[H-].[Li+].[Mg+2].[Na+].[OH-]>>OCC1=C(c2ccccc2F)CCC1",
        "output": "150"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.COc1cccc2ccc(=O)n(CCO)c12.CS(C)=O.ClCCl.O.O=C(Cl)C(=O)Cl>>COc1cccc2ccc(=O)n(CC=O)c12",
        "output": "142"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1Cc2cc(-c3ccc(-c4cncc(N)c4)s3)ccc2C1=O.COc1cccc(S(=O)(=O)Cl)c1>>COc1cccc(S(=O)(=O)Nc2cncc(-c3ccc(-c4ccc5c(c4)CN(C)C5=O)s3)c2)c1",
        "output": "554"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.COC(=O)c1nc(-c2cnccn2)n(-c2ccc(OC)nc2)n1.Cl.O.O.[Li+].[OH-]>>COc1ccc(-n2nc(C(=O)O)nc2-c2cnccn2)cn1",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrBr.CC(=O)O.CCCCCC.O=C1CNc2ncccc2CN1>>O=C1CNc2ncc(Br)cc2CN1",
        "output": "292"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC#N.CCCC[N+](CCCC)(CCCC)CCCC.COc1ccccc1N1CCN(CCCBr)CC1.O=c1[nH]c(=O)n(Cc2ccccc2)cc1C=NO.[F-]>>COc1ccccc1N1CCN(CCCn2c(=O)c(C=NO)cn(Cc3ccccc3)c2=O)CC1",
        "output": "327"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)c1ccc2ccccc2c1.COC(=O)Cc1ccccc1CON.Cl.c1ccncc1>>COC(=O)Cc1ccccc1CON=C(C)c1ccc2ccccc2c1",
        "output": "212"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(CCN)N1CCC2(CC1)OCCO2.Cc1cccc(C)c1C(=O)O>>Cc1cccc(C)c1C(=O)NCCC(C)N1CCC2(CC1)OCCO2",
        "output": "334"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C=C(C)C(=O)OCCCCCCCCO.Cl.ClCCl.O=C(Cl)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1.c1ccncc1>>C=C(C)C(=O)OCCCCCCCCOC(=O)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1",
        "output": "51"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCNCC1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].O=[N+]([O-])c1cccc(I)c1.[Cs+].[Cs+].[Pd].[Pd]>>CC(C)(C)OC(=O)N1CCN(c2cccc([N+](=O)[O-])c2)CC1",
        "output": "931"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCNCC1.CCO.NS(=O)(=O)c1ccc2c(c1)CC(=O)N2.O=Cc1cc2ccccc2[nH]1>>NS(=O)(=O)c1ccc2c(c1)C(=Cc1cc3ccccc3[nH]1)C(=O)N2",
        "output": "440"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)c1cnc(SC)nc1[C@H]1CCCO1.O.O.[Li+].[OH-]>>CSc1ncc(C(=O)O)c([C@H]2CCCO2)n1",
        "output": "152"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(O)(C(=O)O)C(F)(F)F.CCN(CC)CC.CCOCC.ClCCl.N#Cc1cc(C(=O)c2ccccc2)ccc1N.O=S(Cl)Cl>>CC(O)(C(=O)Nc1ccc(C(=O)c2ccccc2)cc1C#N)C(F)(F)F",
        "output": "365"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "O=C(O)c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1.c1ccc2c(C3CCNCC3)c[nH]c2c1>>O=C(c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1)N1CCC(c2c[nH]c3ccccc23)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CS(=O)(=O)N1CCC(N)CC1.Fc1cccc(-c2n[nH]c3nc(Cl)ncc23)c1.O=C(O)C(F)(F)F>>CS(=O)(=O)N1CCC(Nc2ncc3c(-c4cccc(F)c4)n[nH]c3n2)CC1",
        "output": "578"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCN(C(C)C)C(C)C.CO.COc1cc2c(cc1-c1ccc(N)nc1)CCC2.ClCCl.O=C(Cl)c1c(F)cccc1F.[Na+].[OH-]>>COc1cc2c(cc1-c1ccc(NC(=O)c3c(F)cccc3F)nc1)CCC2",
        "output": "463"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOc1cc([N+](=O)[O-])ccc1OC.CO.[Pd]>>CCOc1cc(N)ccc1OC",
        "output": "202"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)OC(C)=O.CCN(CC)CC.COc1ccc(C2CCNCC2)c2sc(NC(=O)c3ccnc(N4CCOCC4)c3)nc12.Cl.O.O=C([O-])O.[Na+]>>COc1ccc(C2CCN(C(C)=O)CC2)c2sc(NC(=O)c3ccnc(N4CCOCC4)c3)nc12",
        "output": "369"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CO.COC(=O)c1ccccc1NC(=O)c1cc2cc(OC)c(OC)cc2s1.[Na+].[OH-]>>COc1cc2cc(C(=O)Nc3ccccc3C(=O)O)sc2cc1OC",
        "output": "247"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C[C@]1(c2cc(N)ccc2F)N=C(N)OC[C@@H]1OCC(F)(F)F.O=C(O)c1ccc(Cl)cn1>>C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)N=C(N)OC[C@@H]1OCC(F)(F)F",
        "output": "985"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N1CCC(Nc2nc3cccc(S(N)(=O)=O)c3o2)CC1.ClCCl.O=C(O)C(F)(F)F>>NS(=O)(=O)c1cccc2nc(NC3CCNCC3)oc12",
        "output": "575"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)c1ccc(C(=O)CCCCl)cc1.Cl.O=C(NC1CCNCC1)c1ccccc1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)c1ccc(C(=O)CCCN2CCC(NC(=O)c3ccccc3)CC2)cc1",
        "output": "138"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)O.CN(C)C=O.O=[N+]([O-])c1ccc(Cl)nc1.[H-].[Na+]>>CC(C)Oc1ccc([N+](=O)[O-])cn1",
        "output": "433"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCO.Cc1cc(OCc2ccccc2)cc(OS(=O)(=O)c2cccc3ccccc23)c1.[Pd]>>Cc1cc(O)cc(OS(=O)(=O)c2cccc3ccccc23)c1",
        "output": "23"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC#N.CC(=O)[O-].CCN(CC)CC.Cc1ccccc1NN.O.O=C(Cl)C12CC3CC(CC(C3)C1)C2.[NH4+]>>Cc1ccccc1NNC(=O)C12CC3CC(CC(C3)C1)C2",
        "output": "450"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.CCOC(=O)Cn1nc(Br)c2c([N+](=O)[O-])cccc21.NN>>NNC(=O)Cn1nc(Br)c2c([N+](=O)[O-])cccc21",
        "output": "164"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1cncc(-c2ccnc(Nc3cc([N+](=O)[O-])ccc3C)n2)c1.Cc1ccc(N)cc1Nc1nccc(-c2cncc(N3CCCC3)c2)n1>>COc1cncc(-c2ccnc(Nc3cc(N)ccc3C)n2)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(OC2CCCCCC2)cn1.CO.Cl>>NCc1ccc(OC2CCCCCC2)cn1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)c1cnc2ccc(Br)cc2c1N[C@@H]1CC[C@@H](CN(C)C)CC1.CC1(C)OB(c2cc(Cl)c(O)c(Cl)c2)OC1(C)C>>CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)cc2c1N[C@@H]1CC[C@@H](CN(C)C)CC1",
        "output": "933"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)C=O.CN(C)c1ccncc1.O=C=Nc1cccc2ccccc12.OCc1ccc(CO)cc1>>O=C(Nc1cccc2ccccc12)OCc1ccc(CO)cc1",
        "output": "34"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN1CCC(N)CC1.Clc1c2ccccc2nc2ccccc12>>CCN1CCC(Nc2c3ccccc3nc3ccccc23)CC1",
        "output": "78"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.Cc1cc(=O)n(-c2ccccc2)c(C)c1C(=O)N[C@H](c1cccc(F)c1)C1CCC1.O=C1CCC(=O)N1Br>>Cc1c(C(=O)N[C@H](c2cccc(F)c2)C2CCC2)c(C)n(-c2ccccc2)c(=O)c1Br",
        "output": "518"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.O.O=[N+]([O-])c1cc2n(n1)CCN(C1CC1)C2.[Cl-].[Fe].[NH4+]>>Nc1cc2n(n1)CCN(C1CC1)C2",
        "output": "684"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1c(C)n(C(C)C)c2cc(-c3ccc(OCc4c(-c5c(Cl)cccc5Cl)noc4C(C)C)cc3C)ccc12.Cl.[Na+].[OH-]>>Cc1cc(OCc2c(-c3c(Cl)cccc3Cl)noc2C(C)C)ccc1-c1ccc2c(C(=O)O)c(C)n(C(C)C)c2c1",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCO.COc1ccc(Cn2c(-c3ccccc3)nc(Cl)c2CC(=O)O)cc1C.ClCCl.[Al+3].[Cl-].[Cl-].[Cl-]>>Cc1cc(Cn2c(-c3ccccc3)nc(Cl)c2CC(=O)O)ccc1O",
        "output": "207"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(=O)Cl.N.O=C(O)CCc1cccc(OCc2ccccc2)c1>>NC(=O)CCc1cccc(OCc2ccccc2)c1",
        "output": "313"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COc1cnc(-n2c(=S)[nH]c3cc(C(=O)O)ccc3c2=O)nc1OC.F[P-](F)(F)(F)(F)F.NCc1cccc(C(=O)c2ccccc2)c1>>COc1cnc(-n2c(=S)[nH]c3cc(C(=O)NCc4cccc(C(=O)c5ccccc5)c4)ccc3c2=O)nc1OC",
        "output": "753"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CNC.COc1cc2c(Nc3cc(O)c(Cl)cc3F)c(C#N)cnc2cc1OCCCl.[I-].[Na+]>>COc1cc2c(Nc3cc(O)c(Cl)cc3F)c(C#N)cnc2cc1OCCN(C)C",
        "output": "138"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)N(C)C.CCN(C(C)C)C(C)C.CCOc1cc(F)ccc1[N+](=O)[O-].CN1CCCNCC1.O>>CCOc1cc(N2CCCN(C)CC2)ccc1[N+](=O)[O-]",
        "output": "26"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)Cc1c(C)nn(Cc2ccc([N+](=O)[O-])cc2)c1C.[Pd]>>COC(=O)Cc1c(C)nn(Cc2ccc(N)cc2)c1C",
        "output": "507"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.ClCCl.O=C(Cl)c1ccc([N+](=O)[O-])cc1.O=C([O-])O.O=C1CCCNc2ccccc21.[Na+]>>O=C1CCCN(C(=O)c2ccc([N+](=O)[O-])cc2)c2ccccc21",
        "output": "614"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.ClCCl.Nc1ccccc1.O.O=C(O)c1ccc(B(O)O)cc1>>O=C(Nc1ccccc1)c1ccc(B(O)O)cc1",
        "output": "50"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].CCCC[O-].CCOC(C)=O.Cc1nn(C)c2nc(Cl)c(CN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnn(C)n3)cc12.NCC1CC1.[K+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Cc1nn(C)c2nc(NCC3CC3)c(CN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnn(C)n3)cc12",
        "output": "70"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCC(NC2CCCCC2)CC1.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Cc1ccc(-c2c(C#N)c(CC(C)C)nc(C)c2C(=O)O)cc1.ClCCl.O=C(Cl)C(=O)Cl>>Cc1ccc(-c2c(C#N)c(CC(C)C)nc(C)c2C(=O)N(C2CCCCC2)C2CCCCC2)cc1",
        "output": "256"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.COC(=O)C(O)c1cc(F)cc(F)c1.NN.O>>NNC(=O)C(O)c1cc(F)cc(F)c1",
        "output": "130"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCC(c2nc(C(F)(F)F)cn2CCN2CCCC2)CC1.CO.Cl.O=C(O)CCC(=O)O>>FC(F)(F)c1cn(CCN2CCCC2)c(C2CCNCC2)n1",
        "output": "575"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)CC(=O)N1CCN(C(=O)c2ccccc2Br)CC1.Cl>>O=C(O)CC(=O)N1CCN(C(=O)c2ccccc2Br)CC1",
        "output": "278"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "Cc1ccc(N)cc1C.O=C(O)c1ccc([N+](=O)[O-])cc1>>Cc1ccc(NC(=O)c2ccc([N+](=O)[O-])cc2)cc1C",
        "output": "50"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCOC(C)=O.COC(=O)Cc1cc(OCc2ccccc2)c2cc(F)ccc2c1Br.[Br-].[Br-].[Pd].[Zn+2]>>COC(=O)Cc1cc(O)c2cc(F)ccc2c1Br",
        "output": "23"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COCCOC(=O)Cl.NC[C@@H]1C[C@H](n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc32)C1>>COCCOC(=O)NC[C@@H]1C[C@H](n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc32)C1",
        "output": "94"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(C)=O.Cl.Cl[Sn]Cl.O=[N+]([O-])c1cccnc1NC1CCN(Cc2ccccc2)CC1>>Nc1cccnc1NC1CCN(Cc2ccccc2)CC1",
        "output": "269"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)NCc1ccnc(C2(N)CC2)c1.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cl.F[P-](F)(F)(F)(F)F.O=C(NC1(C(=O)O)CC1)OCc1ccccc1>>CC(C)(C)OC(=O)NCc1ccnc(C2(NC(=O)C3(NC(=O)OCc4ccccc4)CC3)CC2)c1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCN(CC)CC.CO.Cc1cccc(C[C@H](N)C(=O)O)c1>>Cc1cccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)c1",
        "output": "626"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "N#Cc1ccc(B(O)O)cc1.Oc1c(F)cc(Br)cc1Cl>>N#Cc1ccc(-c2cc(F)c(O)c(Cl)c2)cc1",
        "output": "837"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)(C)OC(=O)NCC=O.CO.ClCCl.ClCCl.NC1Cc2ccc(Br)cc2C1.[Na+]>>CC(C)(C)OC(=O)NCCNC1Cc2ccc(Br)cc2C1",
        "output": "426"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(N)CO.ClCCl.O=C(Cl)c1ccccc1>>CC(C)(CO)NC(=O)c1ccccc1",
        "output": "271"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN(C)C=O.CNC.Cl.O=C([O-])[O-].O=c1c(OCc2ccccc2)nn(CCBr)c(=O)n1COCc1ccccc1.[K+].[K+]>>CN(C)CCn1nc(OCc2ccccc2)c(=O)n(COCc2ccccc2)c1=O",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CC(C)OC(=O)N=NC(=O)OC(C)C.O=C(NCCCO)c1ccc(C(F)(F)F)cc1.Oc1c(Cl)cc(OCc2ccccc2)cc1Cl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>O=C(NCCCOc1c(Cl)cc(OCc2ccccc2)cc1Cl)c1ccc(C(F)(F)F)cc1",
        "output": "550"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Cc1ccc(I)cc1[N+](=O)[O-].ClC(Cl)(Cl)Cl.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>O=[N+]([O-])c1cc(I)ccc1CBr",
        "output": "29"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)Oc1cc(F)ccc1C(F)(F)C(=O)O.Cl.NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O.O=C([O-])O.O=P(Cl)(Cl)Cl.[Na+].c1ccncc1>>CC(C)Oc1cc(F)ccc1C(F)(F)C(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O",
        "output": "599"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COC(=O)C(C)(C)N.COc1cc(Cl)cc(C(=O)NCc2ccc(C#N)cc2OCC(=O)O)c1.Cl>>COC(=O)C(C)(C)NC(=O)COc1cc(C#N)ccc1CNC(=O)c1cc(Cl)cc(OC)c1",
        "output": "129"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCOC(CCNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)OCC.Cl>>O=CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1",
        "output": "409"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCO.COc1ccc(F)c(C=O)c1F.[BH4-].[Na+]>>COc1ccc(F)c(CO)c1F",
        "output": "356"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.Cc1ncc([N+](=O)[O-])cc1Nc1nccc(-c2cccnc2)n1.[H][H].[Ni]>>Cc1ncc(N)cc1Nc1nccc(-c2cccnc2)n1",
        "output": "269"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1COCCO1.CC(=O)[O-].CC(=O)[O-].CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.C[Si](C)(C)CCOCn1nc(-c2ccc(Br)cc2)c2c1-c1ccsc1C2.Nc1ccncc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd+2]>>C[Si](C)(C)CCOCn1nc(-c2ccc(Nc3ccncc3)cc2)c2c1-c1ccsc1C2",
        "output": "405"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC1=C(C(=O)O)C(c2ccc(Cl)cc2F)CC(=O)N1.CN(C)C=O.N=C=N.Nc1ccc2[nH]nc(Cl)c2c1>>CC1=C(C(=O)Nc2ccc3[nH]nc(Cl)c3c2)C(c2ccc(Cl)cc2F)CC(=O)N1",
        "output": "170"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.C[C@@H]1CN(Cc2ccccc2)[C@@H](C)CN1.FC(F)(F)c1nnc2ccc(Cl)nn12>>C[C@@H]1CN(Cc2ccccc2)[C@@H](C)CN1c1ccc2nnc(C(F)(F)F)n2n1",
        "output": "406"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCO.O=Cc1ccc(OC(F)F)c(OCC2CC2)c1.[BH4-].[Na+].[Na+].[OH-]>>OCc1ccc(OC(F)F)c(OCC2CC2)c1",
        "output": "356"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrBr.CC(=O)O.Nc1ccc(-c2ccc(C(F)(F)F)cc2)cc1F>>Nc1c(F)cc(-c2ccc(C(F)(F)F)cc2)cc1Br",
        "output": "98"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Nc1ccc(C(=O)c2ccccc2F)cc1.O=C(O)C(O)(C(F)(F)F)C(F)(F)F.O=C(n1ccnc1)n1ccnc1>>O=C(c1ccc(NC(=O)C(O)(C(F)(F)F)C(F)(F)F)cc1)c1ccccc1F",
        "output": "365"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)=O.COC(=O)[C@H](Cc1ccccc1)Nc1cccc(-c2ccc(O)cc2)c1.COc1cccc(CBr)c1.O=C([O-])[O-].[K+].[K+]>>COC(=O)[C@H](Cc1ccccc1)Nc1cccc(-c2ccc(OCc3cccc(OC)c3)cc2)c1",
        "output": "127"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)N1CCC2(CC1)CC(O[Si](C)(C)C(C)(C)C)c1cc(-c3noc(=O)[nH]3)ccc1O2.CCO.O=C([O-])O.[Na+]>>CC(C)(C)OC(=O)N1CCC2(CC1)CC(O)c1cc(-c3noc(=O)[nH]3)ccc1O2",
        "output": "708"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)NCc1ccc(CCC(=O)O)cc1.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.O.O=C(OCc1ccccc1)N1CCNCC1>>CC(C)(C)OC(=O)NCc1ccc(CCC(=O)N2CCN(C(=O)OCc3ccccc3)CC2)cc1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CC(=O)[O-].CO.COc1c(C(C)=O)cc(Cl)c(C)c1N1CCCC1=O.[BH3-]C#N.[NH4+].[Na+]>>COc1c(C(C)N)cc(Cl)c(C)c1N1CCCC1=O",
        "output": "552"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "BrCC1CC1.CN(C)C=O.N#Cc1ccc2[nH]ccc2c1>>N#Cc1ccc2c(ccn2CC2CC2)c1",
        "output": "470"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1ccc2nc(NC(=O)c3ccc(Cl)cc3)nc(N[C@H]3CCCC[C@H]3NC(=O)OC(C)(C)C)c2c1.ClCCl.O=C(O)C(F)(F)F.O=C([O-])O.[Na+]>>COc1ccc2nc(NC(=O)c3ccc(Cl)cc3)nc(N[C@H]3CCCC[C@H]3N)c2c1",
        "output": "538"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].O.O=C(O)c1cccc(I)c1.O=C([O-])[O-].OB(O)c1cc(F)cc(F)c1.[Na+].[Na+].[Pd+2]>>O=C(O)c1cccc(-c2cc(F)cc(F)c2)c1",
        "output": "855"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CO.[Pd].c1ccc(CN2CCCC(Oc3ccc(-n4ccnc4)nn3)C2)cc1>>c1cn(-c2ccc(OC3CCCNC3)nn2)cn1",
        "output": "84"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.ClCCl.O=S(Cl)Cl.OCCOc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12>>ClCCOc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12",
        "output": "96"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CI.COc1cc(C(=O)O)cc(CCCO)c1OC>>COCCCc1cc(C(=O)O)cc(OC)c1OC",
        "output": "140"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.F[P-](F)(F)(F)(F)F.N[C@H]1[C@@H]2c3cc(Oc4ccnc5c4CCC(=O)N5)ccc3O[C@@H]21.O.O=C(O)c1ccc(CO)c(C(F)(F)F)c1>>O=C1CCc2c(Oc3ccc4c(c3)[C@H]3[C@H](NC(=O)c5ccc(CO)c(C(F)(F)F)c5)[C@H]3O4)ccnc2N1",
        "output": "334"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C=O.CNC(=O)c1ccc(C(CCN)c2ccc(F)cc2)cc1.ClCCCl.O.O=C(O)c1ccccc1.On1nnc2ccccc21>>CNC(=O)c1ccc(C(CCNC(=O)c2ccccc2)c2ccc(F)cc2)cc1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1cccc(-c2c(Cl)cccc2C(O)(CCCCOC)CCN(C)C(=O)OC(C)(C)C)c1.Cl>>CCc1cccc(-c2c(Cl)cccc2C(O)(CCCCOC)CCNC)c1",
        "output": "575"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)CCc1csc(-c2ccccc2)n1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>OCCCc1csc(-c2ccccc2)n1",
        "output": "225"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N.Cc1nc2ccc(C(=O)O)cc2nc1C.Cl.F[P-](F)(F)(F)(F)F>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1NC(=O)c1ccc2nc(C)c(C)nc2c1",
        "output": "50"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)Oc1ccc(C(C)(C)C)cc1Cl.O=S(=O)(O)O.O=[N+]([O-])[O-].[K+]>>COC(=O)Oc1cc([N+](=O)[O-])c(C(C)(C)C)cc1Cl",
        "output": "21"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.COC(=O)c1ccc(CN)cn1.Cl.ClCCl.O.O=S(=O)(Cl)c1ccc(F)cc1>>COC(=O)c1ccc(CNS(=O)(=O)c2ccc(F)cc2)cn1",
        "output": "43"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)(C)OC(=O)N1CC=C(c2cc(Nc3ccc4cccnc4c3)ncn2)CC1.ClCCl.O=C(O)C(F)(F)F>>C1=C(c2cc(Nc3ccc4cccnc4c3)ncn2)CCNC1",
        "output": "800"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCN(C(C)C)C(C)C.CCc1cc2c(N3CCNCC3)nc(SCC(=O)OC)nc2s1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN(C)c1cc(C(=O)O)nc(N(C)C)n1.Cl.F[P-](F)(F)(F)(F)F>>CCc1cc2c(N3CCN(C(=O)c4cc(N(C)C)nc(N(C)C)n4)CC3)nc(SCC(=O)OC)nc2s1",
        "output": "605"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CSc1ccc(C(=O)c2cnoc2C2CC2)c(Cl)c1.ClCCl.O=C(OO)c1cccc(Cl)c1.O=S([O-])S(=O)(=O)[O-].[Na+].[Na+]>>CS(=O)c1ccc(C(=O)c2cnoc2C2CC2)c(Cl)c1",
        "output": "500"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.N#CC(O)C1CCCCC1.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>NCC(O)C1CCCCC1",
        "output": "246"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.COCCCn1c2ccccc2c2ccc(C(=O)OC)cc21.[Al+3].[H-].[H-].[H-].[H-].[Li+]>>COCCCn1c2ccccc2c2ccc(CO)cc21",
        "output": "444"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC#N.CCOC(C)=O.COC(=O)c1cc(C2CC2)c(OCC2CCNCC2)cc1F.Fc1cccc(CCl)c1.O.O=C([O-])[O-].[Cl-].[I-].[K+].[K+].[Na+].[Na+]>>COC(=O)c1cc(C2CC2)c(OCC2CCN(Cc3cccc(F)c3)CC2)cc1F",
        "output": "156"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(C)c4cc(F)cc(F)c34)nc12.ClCCl.O=C(O)C(F)(F)F>>CC(C)NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(F)cc(F)c34)nc12",
        "output": "981"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Nc1ccc(F)cc1F.O=C(Cl)OCc1ccccc1.[Na+].[OH-]>>O=C(Nc1ccc(F)cc1F)OCc1ccccc1",
        "output": "509"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.N#Cc1ccc(-c2cc(N3CCOC(c4nc(-c5ccc(Cl)cc5)c[nH]4)C3)nc(N)n2)cc1F.NN>>Nc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2CCOC(c3nc(-c4ccc(Cl)cc4)c[nH]3)C2)n1",
        "output": "945"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN=C=NCCCN(C)C.CN(C)CCN.Cc1[nH]c(C(=O)N2CCC(C(=O)O)CC2)c(C)c1-c1nc2ccc(C(=O)c3ccccc3)cc2[nH]1.Cl.O.On1nnc2ccccc21.c1ccncc1>>Cc1[nH]c(C(=O)N2CCC(C(=O)NCCN(C)C)CC2)c(C)c1-c1nc2ccc(C(=O)c3ccccc3)cc2[nH]1",
        "output": "230"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CN1CCCC1CCCl.COc1ccc2c(c1)CCN(c1ccc(F)cc1)C2Cc1ccc(O)cc1.Cl>>COc1ccc2c(c1)CCN(c1ccc(F)cc1)C2Cc1ccc(OCCC2CCCN2C)cc1",
        "output": "74"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCCCO.CCN(CC)CC.Cl.Cl.Clc1ncnc2[nH]ccc12.NC1(CNC(=O)c2ccc(Cl)cc2)CCNCC1>>NC1(CNC(=O)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1",
        "output": "540"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)=O.CC(C)OC(C)C.CO.COc1ccc(C[C@@H](C)N(Cc2ccccc2)C[C@H](O)c2ccc(OCc3ccccc3)c([N+](=O)[O-])c2)cc1.N.O.O=S([O-])S(=O)[O-].[Na+].[Na+]>>COc1ccc(C[C@@H](C)N(Cc2ccccc2)C[C@H](O)c2ccc(OCc3ccccc3)c(N)c2)cc1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)N(C)S(=O)(=O)c1ccccc1[N+](=O)[O-].CCOC(C)=O.CO.NN.O.[Ni]>>CC(C)N(C)S(=O)(=O)c1ccccc1N",
        "output": "1"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc(OCc4ccccc4)c(C(=O)O)n3)cc12.F[P-](F)(F)(F)(F)F.NCc1ccc(F)cc1.O>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc(OCc4ccccc4)c(C(=O)NCc4ccc(F)cc4)n3)cc12",
        "output": "905"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "COc1cc2c(NC(=O)Nc3c(C)cccc3Cl)ncnc2cc1OCCCN1CCC(CNC(=O)OC(C)(C)C)CC1.O=C(O)C(F)(F)F>>COc1cc2c(NC(=O)Nc3c(C)cccc3Cl)ncnc2cc1OCCCN1CCC(CN)CC1",
        "output": "538"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1CCOC1.CN(C)c1nc2c(C(=O)[O-])cc([N+](=O)[O-])cc2[nH]1.O.O.[Li+].[OH-]>>CN(C)c1nc2c(C(=O)O)cc([N+](=O)[O-])cc2[nH]1",
        "output": "151"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Cc1cc(CCCCCCCOc2ccc(C#N)cc2)on1.O=S(=O)(O)O.OO.[Na+].[OH-]>>Cc1cc(CCCCCCCOc2ccc(C(N)=O)cc2)on1",
        "output": "180"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cc2ccccc2[nH]1.O.[Na+].[OH-]>>O=C(O)c1cc2ccccc2[nH]1",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CN1C2CCC1CC(N)C2.O=C(O)c1cc(Cl)cc2oc(-c3ccccc3)nc12>>CN1C2CCC1CC(NC(=O)c1cc(Cl)cc3oc(-c4ccccc4)nc13)C2",
        "output": "674"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)Cc1nc(C(N)=O)c(O)[nH]1.CO.[Na]>>NC(=O)c1nc(CC(=O)O)[nH]c1O",
        "output": "7"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1cccc(B(O)O)c1.O=C(O)c1cc(C(=O)O)c(C(=O)N(Cc2cccc(Br)c2)[C@H]2CCCc3ccccc32)cc1C(=O)O>>COc1cccc(-c2cccc(CN(C(=O)c3cc(C(=O)O)c(C(=O)O)cc3C(=O)O)[C@H]3CCCc4ccccc43)c2)c1",
        "output": "908"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CN(C)C=O.CN(C)c1ccncc1.Cc1cc([C@@H](C)N)ccc1NS(C)(=O)=O.Cl.O.O=C(O)c1ccc2cc(N3CCCC3)ccc2c1.O=C([O-])O.On1nnc2ccccc21.[Na+]>>Cc1cc([C@@H](C)NC(=O)c2ccc3cc(N4CCCC4)ccc3c2)ccc1NS(C)(=O)=O",
        "output": "753"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNCC1.Cc1ccccc1.O.O=C(O)c1ccccc1.O=C1CSC(=O)N1.O=Cc1cccc(-c2ccccc2OC(F)(F)F)c1>>O=C1NC(=O)C(=Cc2cccc(-c3ccccc3OC(F)(F)F)c2)S1",
        "output": "761"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(=O)N(C)C.N#Cc1cccc(-c2ccc3cc[nH]c(=O)c3c2)c1.O=C1CCC(=O)N1Cl>>N#Cc1cccc(-c2ccc3c(Cl)c[nH]c(=O)c3c2)c1",
        "output": "743"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "Cl.ClCCCl.O=C1CCC(=O)O1.[Al+3].[Cl-].[Cl-].[Cl-].c1ccc(OC2CCCCC2)cc1>>O=C(O)CCC(=O)c1ccc(OC2CCCCC2)cc1",
        "output": "345"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOC(=O)Nc1nc2cc(F)ccc2nc1OC.COc1ccc(N2CCNCC2)cc1>>COc1ccc(N2CCN(C(=O)Nc3nc4cc(F)ccc4nc3OC)CC2)cc1",
        "output": "613"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CO.ClCCl.N.N#CC[C@@H](O)c1cccc(OC2CCCCC2)n1>>NCC[C@@H](O)c1cccc(OC2CCCCC2)n1",
        "output": "246"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N1CCN(CCN2c3ccccc3N(c3ccccc3Cl)S2(=O)=O)CC1.Cl.ClCCl>>O=S1(=O)N(CCN2CCNCC2)c2ccccc2N1c1ccccc1Cl",
        "output": "575"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C=Cc1ccc(C=O)cc1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccccc1.O.OCCO>>C=Cc1ccc(C2OCCO2)cc1",
        "output": "117"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C=O)n(C)c2n1.CN1CCN(C2CNC2)CC1=O.ClCCCl.[Na+]>>CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CC(N4CCN(C)C(=O)C4)C3)n(C)c2n1",
        "output": "944"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CCOc1ccc(CC#N)cc1OCC.N.[Ni]>>CCOc1ccc(CCN)cc1OCC",
        "output": "246"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)Oc1ccc(/C=C/[N+](=O)[O-])cc1C12CC3CC(CC(C3)C1)C2.COC(=O)c1ccc(C23CC4CC(CC(C4)C2)C3)c(OC(C)C)c1>>CC(C)Oc1cc(CO)ccc1C12CC3CC(CC(C3)C1)C2",
        "output": "444"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CCOC1.Cc1ccc(N)cc1C(=O)O.O=C(Cl)c1cccc(C(F)(F)F)c1>>Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C(=O)O",
        "output": "11"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1cc(Cl)cc(Cl)c1.COC(OC)N(C)C>>CN(C)C=CC(=O)c1cc(Cl)cc(Cl)c1",
        "output": "576"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CCOC(=O)c1cc2n(n1)CCNC2.CN(C)C(F)=[N+](C)C.CN(C)C=O.COc1ccc(C(=O)O)cc1.F[P-](F)(F)(F)(F)F.O>>CCOC(=O)c1cc2n(n1)CCN(C(=O)c1ccc(OC)cc1)C2",
        "output": "44"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CO.COC(=O)c1sc([N+](=O)[O-])cc1N=NN(C)C.[Na+].[OH-]>>CN(C)N=Nc1cc([N+](=O)[O-])sc1C(=O)O",
        "output": "152"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1ccc(C(=O)NCc2ccc(S(=O)(=O)C(C)C)cc2)c(=O)n1-c1cccc(C(F)(F)F)c1.ClCCl.O=C(O)C(F)(F)F.O=C1CCC(=O)N1I>>Cc1c(I)cc(C(=O)NCc2ccc(S(=O)(=O)C(C)C)cc2)c(=O)n1-c1cccc(C(F)(F)F)c1",
        "output": "783"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1COCCOCCOCCOCCOCCOCCN1.O=C(Cl)CC12CC3CC(CC(C3)C1)C2>>O=C(CC12CC3CC(CC(C3)C1)C2)N1CCOCCOCCOCCOCCOCCOCC1",
        "output": "125"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.COCCNc1ccc(C#N)c(Oc2ccc(Br)c(C3OCCO3)c2)n1.Cl.O>>COCCNc1ccc(C#N)c(Oc2ccc(Br)c(C=O)c2)n1",
        "output": "655"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)Nc1c(C)cc(C)cc1C.CO.O.[Li+].[OH-]>>Cc1cc(C)c(NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]2O[C@@H]2C(=O)O)c(C)c1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCOCCn1c(N2CCCNCC2)nc2ccccc21.CO.COc1cc(C(=O)N2CCCC(CCOS(C)(=O)=O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC>>CCOCCn1c(N2CCCN(CCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21",
        "output": "496"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl.O=C(O)c1ccc(Br)cc1.O=c1n(-c2cc(Cl)cc(Cl)c2)c(=O)n2n1CC(O)C2>>O=C(OC1Cn2c(=O)n(-c3cc(Cl)cc(Cl)c3)c(=O)n2C1)c1ccc(Br)cc1",
        "output": "33"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Fc1cc2nc(-c3cccnc3Cl)n(CC3CCCCC3)c2cc1F.OCc1ccccc1Cl>>Fc1cc2nc(-c3cccnc3OCc3ccccc3Cl)n(CC3CCCCC3)c2cc1F",
        "output": "433"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.COc1ccc2c(c1/C=C\\CCN1CCN(C(=O)OC(C)(C)C)CC1)O/C(=C\\c1n[nH]c3ccccc13)C2=O.Cl.ClCCl>>COc1ccc2c(c1/C=C\\CCN1CCNCC1)O/C(=C\\c1n[nH]c3ccccc13)C2=O",
        "output": "575"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(C)N1CCC(Oc2ccc(C3(C(=O)O)CCOCC3)cc2)CC1.CN1CCNCC1>>CC(C)N1CCC(Oc2ccc(C3(C(=O)N4CCN(C)CC4)CCOCC3)cc2)CC1",
        "output": "146"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCCCCNc1c(F)cc(F)c2oc(-c3ccc(N(CCCN=[N+]=[N-])C(C)=O)c(F)c3)cc(=O)c12.Cl.O>>CCCCCNc1c(F)cc(F)c2oc(-c3ccc(NCCCN=[N+]=[N-])c(F)c3)cc(=O)c12",
        "output": "504"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Cc1cc(N2CCN(Cc3ccc(C(F)(F)F)cc3)C2=O)sc1C(=O)O.Cc1nc(N2CCN(CC(=O)O)C2=O)sc1C(=O)NCc1ccccc1.NCc1ccc(F)cc1>>Cc1nc(N2CCN(CC(=O)NCc3ccc(F)cc3)C2=O)sc1C(=O)NCc1ccccc1",
        "output": "599"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "ClC(c1ccccc1)(c1ccccc1)c1ccccc1.OCCC1CCC(O)CC1.c1ccncc1>>OC1CCC(CCOC(c2ccccc2)(c2ccccc2)c2ccccc2)CC1",
        "output": "250"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.N#Cc1ccc(CN=[N+]=[N-])c(Cl)c1.O.[Na+].[OH-].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>N#Cc1ccc(CN)c(Cl)c1",
        "output": "562"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCOC(=O)N1CC2CC=C(c3cccnc3)C(C2)C1.Cl.[Na+].[OH-]>>C1=C(c2cccnc2)C2CNCC(C1)C2",
        "output": "283"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1COCCO1.CCOC(=O)C1(C)CCN(c2ncc(Br)cn2)CC1.Cl.O=C([O-])O.[Na+]>>CC1(C(=O)O)CCN(c2ncc(Br)cn2)CC1",
        "output": "281"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C#CCO.C1CCOC1.CCN(C(C)C)C(C)C.ClC(Cl)Cl.Fc1ccc(I)c(F)c1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Cl-].[Cu]I.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccccc2)cc1>>OCC#Cc1ccc(F)cc1F",
        "output": "664"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)OC(C)C.NCCO[N+](=O)[O-].O=C(O)c1cccs1.O=[N+]([O-])O>>O=C(NCCO[N+](=O)[O-])c1cccs1",
        "output": "736"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCS(=O)(=O)c1ccc(Cl)c([N+](=O)[O-])c1.NCC1CCCCO1>>CCS(=O)(=O)c1ccc(NCC2CCCCO2)c([N+](=O)[O-])c1",
        "output": "304"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOc1cc2ncc(C#N)c(Cl)c2cc1OCC.Nc1ccccc1>>CCOc1cc2ncc(C#N)c(Nc3ccccc3)c2cc1OCC",
        "output": "115"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "N#Cc1cc(C(=O)CCC(F)(F)F)c(CN2CCCC2=O)nc1N1CCC(C(=O)O)CC1.NS(=O)(=O)Cc1ccc(F)cc1F>>N#Cc1cc(C(=O)CCC(F)(F)F)c(CN2CCCC2=O)nc1N1CCC(C(=O)NS(=O)(=O)Cc2ccc(F)cc2F)CC1",
        "output": "644"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CCOC(=O)c1ccccc1N(C)S(C)(=O)=O.ClCCl.O=S(=O)([O-])[O-].[BH4-].[Cl-].[Li+].[NH4+].[Na+].[Na+]>>CN(c1ccccc1CO)S(C)(=O)=O",
        "output": "311"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(C)=O.CN(C)C=O.COc1cc(F)ccc1-c1cc(Nc2cc(CO)cc(Cl)n2)ncn1.O=C([O-])O.O=S(Cl)Cl.[Na+]>>COc1cc(F)ccc1-c1cc(Nc2cc(CCl)cc(Cl)n2)ncn1",
        "output": "81"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "ClC(Cl)Cl.O=S(Cl)Cl.OCc1cc(Nc2ccc(Cl)c(Cl)c2)ncn1>>ClCc1cc(Nc2ccc(Cl)c(Cl)c2)ncn1",
        "output": "594"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C[C@H](N)C(=O)OCc1ccccc1.Cc1ccc(S(=O)(=O)O)cc1.O=C(NC(Cc1ccccc1)P(=O)(O)CC(Cc1ccccc1)C(=O)O)OCc1ccccc1>>C[C@H](NC(=O)C(Cc1ccccc1)CP(=O)(O)C(Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)OCc1ccccc1",
        "output": "132"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)[Si](C)(C)Cl.CN(C)C=O.OCCOc1ccc(O)cc1.c1c[nH]cn1>>CC(C)(C)[Si](C)(C)OCCOc1ccc(O)cc1",
        "output": "193"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)O.O=C(O)c1ccc(Cl)c(O)c1>>CC(C)OC(=O)c1ccc(Cl)c(O)c1",
        "output": "33"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.COC(=O)c1cn(CCOC(F)(F)F)c2c(F)ccc(OC(F)(F)F)c12.[Na+].[OH-]>>O=C(O)c1cn(CCOC(F)(F)F)c2c(F)ccc(OC(F)(F)F)c12",
        "output": "152"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "O=C(O)Cc1ccc(C(F)(F)F)cc1.O=S(=O)(O)O.O=[N+]([O-])O>>O=C(O)Cc1ccc(C(F)(F)F)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCCC.CCOC(C)=O.CCOC(C)=O.COc1ccc(-c2nn3c(Cl)cccc3c2-c2ccnc(NC3CCCC3)n2)cc1.NCCN1CCOCC1>>COc1ccc(-c2nn3c(NCCN4CCOCC4)cccc3c2-c2ccnc(NC3CCCC3)n2)cc1",
        "output": "241"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.NCc1ccc(C(F)(F)F)cc1N1CCCCC1.Nc1c(O)cccc1C(=O)O.Oc1cccc2[nH]nnc12>>Nc1c(O)cccc1C(=O)NCc1ccc(C(F)(F)F)cc1N1CCCCC1",
        "output": "753"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.NC[C@@H](O)c1ccccc1.O=Cc1ccc(S(=O)(=O)c2ccccc2)cc1.[Na+]>>O=S(=O)(c1ccccc1)c1ccc(CNC[C@@H](O)c2ccccc2)cc1",
        "output": "468"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C(C)C)C(C)C.COCCl.ClCCl.Oc1ccccc1>>COCOc1ccccc1",
        "output": "375"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)Oc1ccc(-c2nc(-c3ccc(O)c4ccoc34)no2)cc1Cl.CCOC(=O)CBr.CN(C)C=O.CO.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)COc1ccc(-c2noc(-c3ccc(OC(C)C)c(Cl)c3)n2)c2occc12",
        "output": "123"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC.COC(=O)c1ccc(Br)cc1C>>Cc1cc(Br)ccc1CO",
        "output": "444"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "BrC(Br)(Br)Br.CCCCCCCOCCCCCCCO.ClCCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>CCCCCCCOCCCCCCCBr",
        "output": "378"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(C(C)C)C(C)C.CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.ClCCl.F[P-](F)(F)(F)(F)F.Nc1nccs1.O.O=C(Nc1ccc(C(CC2CCCC2)C(=O)O)cc1)c1ccccc1>>O=C(Nc1ccc(C(CC2CCCC2)C(=O)Nc2nccs2)cc1)c1ccccc1",
        "output": "681"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.COC(=O)Cn1c(Br)nc(Br)c1Br.[Na+].[OH-]>>O=C(O)Cn1c(Br)nc(Br)c1Br",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "COc1ccccc1CNCC1CC1.O=C(O)CCCSc1ccc(O)cc1>>COc1ccccc1CN(CC1CC1)C(=O)CCCSc1ccc(O)cc1",
        "output": "633"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCO.OCCCC#Cc1ccc2c(ccn2-c2ccc(F)cc2)c1>>OCCCCCc1ccc2c(ccn2-c2ccc(F)cc2)c1",
        "output": "717"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CO.ClCCl.OC(c1ccccc1)c1c[nH]c2cnccc12>>O=C(c1ccccc1)c1c[nH]c2cnccc12",
        "output": "852"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "COCC(=O)Cl.COc1cc(OCC2CC2)c(-c2ccnc3c(C(=O)NC4CCNCC4)c(C)[nH]c23)cc1F.Cl>>COCC(=O)N1CCC(NC(=O)c2c(C)[nH]c3c(-c4cc(F)c(OC)cc4OCC4CC4)ccnc23)CC1",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1COCCO1.CCN(C(C)C)C(C)C.COc1ccccc1C1CCNCC1.N#Cc1c(Cl)nc(NCCO)nc1NCCO>>COc1ccccc1C1CCN(c2nc(NCCO)nc(NCCO)c2C#N)CC1",
        "output": "296"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCO.CCOC(=O)/C=C/c1ccc(OCCC2(C)OCCO2)cc1Oc1ncc(C(F)(F)F)cc1Cl.Cl.O.[Na+].[OH-]>>CC1(CCOc2ccc(/C=C/C(=O)O)c(Oc3ncc(C(F)(F)F)cc3Cl)c2)OCCO1",
        "output": "122"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrB(Br)Br.CCOC(C)=O.COc1c(Cl)c(C)cc2c1C(C)(C)CC(O)(C(F)(F)F)C2Nc1ccc(F)c2nc(C)ncc12.ClCCl.O=C([O-])O.[Na+]>>Cc1ncc2c(NC3c4cc(C)c(Cl)c(O)c4C(C)(C)CC3(O)C(F)(F)F)ccc(F)c2n1",
        "output": "732"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CN(C)C=O.COc1ccc(C2=C(c3ccc(O)cc3)C(=O)C(C)(C)O2)cc1.Cc1cnc(CCl)c(C)c1.O.O=C([O-])[O-].[Cs+].[Cs+]>>COc1ccc(C2=C(c3ccc(OCc4ncc(C)cc4C)cc3)C(=O)C(C)(C)O2)cc1",
        "output": "616"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(=O)C#N.Cc1ccc(Br)c(F)c1.N#N.O=C(OOC(=O)c1ccccc1)c1ccccc1.O=C1CCC(=O)N1Br>>Fc1cc(CBr)ccc1Br",
        "output": "29"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)SCC(=O)NCCCCCN.CCN(C(C)C)C(C)C.CCOC(C)=O.ClCCl.NC(CO)(CO)CO.O=C(O)C(F)(F)F.O=S(=O)(Cl)c1ccccc1>>CC(=O)SCC(=O)NCCCCCNS(=O)(=O)c1ccccc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "BrB(Br)Br.CO.ClCCl.O=c1ccn(-c2ccc(F)c(F)c2)nc1Cc1cccc(-c2ncc(OCc3ccccc3)cn2)c1>>O=c1ccn(-c2ccc(F)c(F)c2)nc1Cc1cccc(-c2ncc(O)cn2)c1",
        "output": "492"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CC(=O)O.CCOC(=O)C(C)c1ccc2c(c1)OCCO2.O.O.[Na+].[OH-]>>CC(C(=O)O)c1ccc2c(c1)OCCO2",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.Clc1nc(Cl)nc(Cl)n1.Nc1ccc(NC(=O)c2ccc(OCc3ccccc3)cc2OCc2ccccc2)c(O)c1.O=C([O-])O.[Na+]>>O=C(Nc1ccc(Nc2nc(Cl)nc(Cl)n2)cc1O)c1ccc(OCc2ccccc2)cc1OCc1ccccc1",
        "output": "592"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)N.CCNc1nc(Cl)nc(NC(C)C)n1.Clc1nc(Cl)nc(Cl)n1.[Na+].[OH-]>>CC(C)Nc1nc(Cl)nc(Cl)n1",
        "output": "578"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "ClCCOc1ccccc1Br.OC1CCNCC1>>OC1CCN(CCOc2ccccc2Br)CC1",
        "output": "138"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCSc1ccc(C(F)(F)F)cc1NN.O=C(O)c1cc(Cl)cc(C(F)(F)F)c1>>CCSc1ccc(C(F)(F)F)cc1NNC(=O)c1cc(Cl)cc(C(F)(F)F)c1",
        "output": "55"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCCCCCCCCCI.CCO.Oc1cccc2c(O)cccc12.[Na+].[OH-]>>CCCCCCCCCCOc1cccc2c(O)cccc12",
        "output": "198"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCOC(C)=O.COc1cc(C=C2Oc3cc(O)ccc3C2=O)cc(OC)c1.O=C(Cl)c1ccccc1.c1ccncc1>>COc1cc(C=C2Oc3cc(OC(=O)c4ccccc4)ccc3C2=O)cc(OC)c1",
        "output": "482"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "Nc1cc(F)cc(C(F)(F)F)c1.O=C(O)c1cc(Cl)ccc1O>>O=C(Nc1cc(F)cc(C(F)(F)F)c1)c1cc(Cl)ccc1O",
        "output": "50"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC2CN(Cc3ccccc3)CC(C1)C2(C)O.CCO.[Pd]>>CC(C)(C)OC(=O)N1CC2CNCC(C1)C2(C)O",
        "output": "84"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)CC(=O)c1ccc(CBr)cc1.Cc1ccc(C(=O)CC(C)(C)C)cc1>>Cc1ccc(C(O)CC(C)(C)C)cc1",
        "output": "24"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(C)(C)OC(=O)N1CCC(CC(=O)O)CC1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)N1CCC(CC(=O)Cl)CC1",
        "output": "56"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)N[C@H]1Cc2ccccc2[C@H]1Oc1ccc(OCc2ccccc2)cc1.CCOCC.CI.CN(C)C=O.[H-].[Na+]>>CN(C(=O)OC(C)(C)C)[C@H]1Cc2ccccc2[C@H]1Oc1ccc(OCc2ccccc2)cc1",
        "output": "803"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CCOC(C)O.COc1cc2ncc(C#N)c(Cl)c2cc1OC.Nc1cccc(N)c1.O=C([O-])O.[Na+].c1ccncc1>>COc1cc2ncc(C#N)c(Nc3cccc(N)c3)c2cc1OC",
        "output": "115"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C=O.CC(=O)O.CO.O=C(NCc1ccc2c(c1)OCO2)c1cc([N+](=O)[O-])ccc1NC1CCNCC1.[BH3-]C#N.[Na+]>>CN1CCC(Nc2ccc([N+](=O)[O-])cc2C(=O)NCc2ccc3c(c2)OCO3)CC1",
        "output": "217"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.NCCCCCC(=O)O.O=C(Cl)OCc1ccccc1.[Na+].[OH-]>>O=C(O)CCCCCNC(=O)OCc1ccccc1",
        "output": "479"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.Cl.O=S1(=O)CCN2C=CC=C(c3ccc(OC4CCC5(CC4)OCCO5)cc3)C2=N1.[Na+].[OH-]>>O=C1CCC(Oc2ccc(C3=CC=CN4CCS(=O)(=O)N=C34)cc2)CC1",
        "output": "251"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)O.CCN1CCC(C2CCN(C(=O)OCc3ccccc3)CC2)CC1.CO.O.[H][H].[Pd]>>CCN1CCC(C2CCNCC2)CC1",
        "output": "428"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CCN(CCCCN2C(=O)CCC(=O)c3ccccc32)CC1.CCOCC.Cl>>O=C1CCC(=O)N(CCCCN2CCNCC2)c2ccccc21",
        "output": "575"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1cc2cc[nH]c(=O)c2cc1Br.O=P(Cl)(Cl)Cl>>COc1cc2ccnc(Cl)c2cc1Br",
        "output": "100"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC(C)(C)OC(=O)N1CCC(N)CC1.CCOc1ccc2c(c1-c1ncnc3c(C(=O)O)c[nH]c13)OCO2>>CCOc1ccc2c(c1-c1ncnc3c(C(=O)NC4CCN(C(=O)OC(C)(C)C)CC4)c[nH]c13)OCO2",
        "output": "737"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(-c3cc(CC(=O)OC)ccc3OC)c(C)c2)cc1C)CC.CO.[Cl-].[NH4+].[Na+].[OH-]>>CCC(O)(/C=C/c1ccc(C(CC)(CC)c2ccc(-c3cc(CC(=O)O)ccc3OC)c(C)c2)cc1C)CC",
        "output": "88"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CO.COc1ccc(Cn2cc3c(n2)c(Cl)nc2ccc(OC)cc23)cc1.Cl.Nc1ccc(N2CCN(C3CCCC3)CC2)cc1>>COc1ccc2nc(Nc3ccc(N4CCN(C5CCCC5)CC4)cc3)c3n[nH]cc3c2c1",
        "output": "998"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.Cl.Cl.ClCCl.F[P-](F)(F)(F)(F)F.NCC1CCN(CCNS(=O)(=O)C(F)(F)F)CC1.O=C(O)c1cc(Br)cc(C(F)(F)F)c1>>O=C(NCC1CCN(CCNS(=O)(=O)C(F)(F)F)CC1)c1cc(Br)cc(C(F)(F)F)c1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CO.Cl.O=[N+]([O-])c1ccc2[nH]cc(CCNCc3cccc(Oc4ccccc4)c3)c2c1.[BH4-].[Na+]>>Nc1ccc2[nH]cc(CCNCc3cccc(Oc4ccccc4)c3)c2c1",
        "output": "1"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.Cl.NCC1CCc2c(nc3cc(Cl)ccc3c2N)C1.O=C(O)CC1CCSS1.O=C(O)C[C@@H]1CCSS1>>Nc1c2c(nc3cc(Cl)ccc13)CC(CNC(=O)CC1CCSS1)CC2",
        "output": "230"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CCOC(=O)/N=N/C(=O)OCC.COC[C@]1(O)CCCC[C@H]1n1cnc(C(=O)N2CCN(Cc3ccccc3)C[C@H]2CCO)c1-c1ccccc1.Oc1ccccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>COC[C@]1(O)CCCC[C@H]1n1cnc(C(=O)N2CCN(Cc3ccccc3)C[C@H]2CCOc2ccccc2)c1-c1ccccc1",
        "output": "550"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "O=[N+]([O-])c1ccc(CBr)cc1.O[C@H](COCc1ccccc1)[C@@H](O)[C@H](O)[C@@H](COCc1ccccc1)OCc1ccccc1>>O=[N+]([O-])c1ccc(CO[C@H](COCc2ccccc2)[C@@H](O)[C@H](O)[C@@H](COCc2ccccc2)OCc2ccccc2)cc1",
        "output": "464"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Fc1c(Cl)ccc2cc[nH]c12.O.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>O=Cc1c[nH]c2c(F)c(Cl)ccc12",
        "output": "266"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.COC(=O)C(C)(C)COCc1ccccc1.Cl.[Na+].[OH-]>>CC(C)(COCc1ccccc1)C(=O)O",
        "output": "361"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(CC)CCCl.CN(C)C=O.Cl.O=C([O-])[O-].Oc1cccc2c1c1ccccc1n2Cc1ccccc1.[K+].[K+]>>CCN(CC)CCOc1cccc2c1c1ccccc1n2Cc1ccccc1",
        "output": "74"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C.CO.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.c1ccncc1>>Cc1ccc(S(=O)(=O)O[C@H]2CC[C@@]3(C)C(=CC[C@H]4[C@@H]5CC[C@H]([C@H](C)CCCC(C)C)[C@@]5(C)CC[C@@H]43)C2)cc1",
        "output": "197"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "Nc1cccc(C(F)(F)F)c1.O=c1[nH]c2nccc(Cl)c2c2ccccc12>>O=c1[nH]c2nccc(Nc3cccc(C(F)(F)F)c3)c2c2ccccc12",
        "output": "922"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.Nc1ccc(CC(=O)O)cc1.O>>CC(C)(C)OC(=O)Nc1ccc(CC(=O)O)cc1",
        "output": "735"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)(C)[O-].COc1cnc(Cl)c(Br)c1.Cc1ccc(N2CCNCC2)cc1.Cc1ccccc1.[Na+].[Pd+2].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>COc1cnc(Cl)c(N2CCN(c3ccc(C)cc3)CC2)c1",
        "output": "597"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CNC.ClCCl.O=C(O)c1cccc(S(=O)(=O)Cl)c1>>CN(C)S(=O)(=O)c1cccc(C(=O)O)c1",
        "output": "99"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)c1ccc(NS(C)(=O)=O)c(N)c1.O=C(Cl)c1ccc(F)cc1F.c1ccncc1>>CC(=O)c1ccc(NS(C)(=O)=O)c(NC(=O)c2ccc(F)cc2F)c1",
        "output": "11"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)COc1cccc2sc(C(=O)O)cc12.Cl.Cl.Cl.NC1CCN(CCN2CCCCC2)CC1>>CC(C)COc1cccc2sc(C(=O)NC3CCN(CCN4CCCCC4)CC3)cc12",
        "output": "736"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCCCCCCC(=O)Cl.CCCCOc1cc(CCC(=O)OC)ccc1-c1csc(CNC)c1.CCN(CC)CC.CN(C)c1ccccn1.ClCCl.O=C([O-])O.[Na+]>>CCCCCCCC(=O)N(C)Cc1cc(-c2ccc(CCC(=O)OC)cc2OCCCC)cs1",
        "output": "125"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC1=C(C(=O)O)C(c2ccc(Cl)cc2F)CC(=O)N1.CCN(CC)CC.CCOC(C)=O.CCc1n[nH]c2ccc(N)cc12.CN(C)C=O.Cl.ClCCCl>>CCc1n[nH]c2ccc(NC(=O)C3=C(C)NC(=O)CC3c3ccc(Cl)cc3F)cc12",
        "output": "170"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.Cc1ccc(S(=O)(=O)O)cc1.O.O.O=C(O)CCCCCCC1CCCCC1=O.O=C([O-])O.[Cl-].[Na+].[Na+].c1ccccc1>>CCOC(=O)CCCCCCC1CCCCC1=O",
        "output": "17"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)c1ccncc1.CO.ClCCCl.ClCCl.O=C(O)c1cnccc1Br>>COC(=O)c1cnccc1Br",
        "output": "195"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C1CCOC1.CC(C)(C)OC(=O)NCC[C@@H](Oc1cc(Cl)ccc1C#N)c1nccs1.CCCC(C)C.CCOC(C)=O.CI.[H-].[Na+]>>CN(CC[C@@H](Oc1cc(Cl)ccc1C#N)c1nccs1)C(=O)OC(C)(C)C",
        "output": "803"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.COC(=O)c1cn(C)c2cc(C3=CCC(O[Si](C)(C)C(C)(C)C)CC3)ccc12.[F-]>>COC(=O)c1cn(C)c2cc(C3=CCC(O)CC3)ccc12",
        "output": "708"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CN(C)C=O.Clc1ncccn1.O=C([O-])[O-].[K+].[K+].c1ccn(CCCCN2CCNCC2)c1>>c1cnc(N2CCN(CCCCn3cccc3)CC2)nc1",
        "output": "36"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(F)cc2Cl)C[C@H]1COCc1ccc(OC)cc1.N#CC1(N)CC1>>COc1ccc(COC[C@@H]2C[C@H](S(=O)(=O)c3ccc(F)cc3Cl)C[C@H]2C(=O)NC2(C#N)CC2)cc1",
        "output": "64"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CCON.N#Cc1ccc(N2C(=O)N(c3ccc(C(=O)O)c(F)c3)[C@@H]3CCCC[C@H]32)cc1C(F)(F)F>>CCN(CC)CCONC(=O)c1ccc(N2C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)[C@@H]3CCCC[C@H]32)cc1F",
        "output": "741"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCc1ccc(NC(C)=O)cc1.O=C([O-])[O-].O=[N+]([O-])O.[Na+].[Na+]>>CCc1ccc(NC(C)=O)cc1[N+](=O)[O-]",
        "output": "21"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "NNc1ccc(C(F)(F)F)cc1.O=Cc1ccc(O)cc1O>>Oc1ccc(C=NNc2ccc(C(F)(F)F)cc2)c(O)c1",
        "output": "167"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "BrCC1CC1.CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)C[C@H]1CCO.CN(C)C=O.[H-].[Na+]>>CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)C[C@H]1CCOCC1CC1",
        "output": "95"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.CC(C)(C)[O-].CCO.CCOC(C)=O.C[C@@H]1CN(c2ccc(C#N)c(F)c2)[C@@H](C)CN1.O.[K+]>>CCOc1cc(N2C[C@@H](C)NC[C@@H]2C)ccc1C#N",
        "output": "485"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC#N.CN.Clc1nc(Cl)nc(-c2ccccc2)n1.O.[Na+].[OH-]>>CNc1nc(Cl)nc(-c2ccccc2)n1",
        "output": "578"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(C)(C)OC(=O)N1[C@H](CO)[C@H]2CC[C@@H]1C2.CCN(C(C)C)C(C)C.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CC(C)(C)OC(=O)N1[C@H](C=O)[C@H]2CC[C@@H]1C2",
        "output": "610"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)[O-].CC(=O)[O-].CC(C)Oc1ccc(B(O)O)cc1.CCN(CC)CC.CCOC(C)=O.CCc1cc2c(=O)[nH]c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3F)c2s1.ClCCl.[Cu+2].c1ccncc1>>CCc1cc2c(=O)n(-c3ccc(OC(C)C)cc3)c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3F)c2s1",
        "output": "962"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.COc1ccc(-c2nn3ccc(NC4CCCC4)cc3c2-c2ccnc(NC3CCCC3)n2)cc1.ClCCl>>Oc1ccc(-c2nn3ccc(NC4CCCC4)cc3c2-c2ccnc(NC3CCCC3)n2)cc1",
        "output": "48"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "N[C@H]1CCCc2ccccc21.O=Cc1ccc(Cl)cc1Cl>>Clc1ccc(CN[C@H]2CCCc3ccccc32)c(Cl)c1",
        "output": "683"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.N#Cc1ccc(F)cc1.O.O=[N+]([O-])c1cccc2[nH]cnc12.[H-].[Na+]>>N#Cc1ccc(-n2cnc3c([N+](=O)[O-])cccc32)cc1",
        "output": "701"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CCCCc1nc(Cl)c(CO)[nH]1.O.[K+].[OH-]>>CCCCc1nc(Cl)c(C=O)[nH]1",
        "output": "287"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCC2=NCCCN2CC1.CCOC(C)=O.CI.CN(C)C=O.COc1cc(CN)c2c(c1CC(=O)OCc1ccccc1)Sc1c(ccc(OC)c1C(=O)OC(C)(C)C)N2C(=O)CCCC(=O)O.O>>COC(=O)CCCC(=O)N1c2ccc(OC)c(C(=O)OC(C)(C)C)c2Sc2c(CC(=O)OCc3ccccc3)c(OC)cc(CN)c21",
        "output": "415"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(C)(C)OC(=O)N(Cc1cccc([N+](=O)[O-])c1)[C@H](C(=O)OC1CCCC1)c1ccccc1.CCO.[Pd]>>CC(C)(C)OC(=O)N(Cc1cccc(N)c1)[C@H](C(=O)OC1CCCC1)c1ccccc1",
        "output": "71"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "NC(CO)CO.O=C(O)c1cccc(S(=O)(=O)Cc2c(O[C@H](Cn3ccnc3)c3ccccc3)ccc3c2CCCC3=O)c1>>O=C(NC(CO)CO)c1cccc(S(=O)(=O)Cc2c(O[C@H](Cn3ccnc3)c3ccccc3)ccc3c2CCCC3=O)c1",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)[O-].CCOC(C)=O.CN(C)C=O.O=C(O)c1ccnc(-c2ccc(Oc3ccc(Cl)cc3F)cc2)n1.O=C(c1ncc[nH]1)c1ncc[nH]1.[NH4+]>>NC(=O)c1ccnc(-c2ccc(Oc3ccc(Cl)cc3F)cc2)n1",
        "output": "136"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(=O)OC(C)=O.CN(C)c1ccccn1.ClCCl.NC[C@H]1CN(c2ccc(C3CN(C(=O)OCc4ccccc4)C3)c(F)c2)C(=O)O1.c1ccncc1>>CC(=O)NC[C@H]1CN(c2ccc(C3CN(C(=O)OCc4ccccc4)C3)c(F)c2)C(=O)O1",
        "output": "339"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)N1CCc2cc(I)c(OCCC(=O)O)cc2CC1.CN(C)C=O.ClCCl.O=C(Cl)C(=O)Cl.[Al+3].[Cl-].[Cl-].[Cl-]>>CCOC(=O)N1CCc2cc(I)c3c(c2CC1)C(=O)CCO3",
        "output": "274"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCN(CC)CC.CCOC(=O)C1CC(O)CN(C(=O)c2ccc(F)cc2)C1.CS(C)=O.ClCCl.O=C(Cl)C(=O)Cl>>CCOC(=O)C1CC(=O)CN(C(=O)c2ccc(F)cc2)C1",
        "output": "650"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.Cc1c(C(=O)NN2CCCCC2)nc(-c2ccc(Cl)cc2Cl)n1-c1ccc(O)cc1.ClCCl.O.O=S(=O)(Cl)CCC(F)(F)F>>Cc1c(C(=O)NN2CCCCC2)nc(-c2ccc(Cl)cc2Cl)n1-c1ccc(OS(=O)(=O)CCC(F)(F)F)cc1",
        "output": "149"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CCOC1.O.[N-]=[N+]=NCc1cc(Oc2cnccn2)cc2c1C(CC(=O)O)OB2O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>NCc1cc(Oc2cnccn2)cc2c1C(CC(=O)O)OB2O",
        "output": "562"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.COC(=O)COc1ccc(OCC#Cc2cc(Br)cc(C#Cc3ccc(C(F)(F)F)cc3)c2)cc1C.[Na+].[OH-]>>Cc1cc(OCC#Cc2cc(Br)cc(C#Cc3ccc(C(F)(F)F)cc3)c2)ccc1OCC(=O)O",
        "output": "88"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC#N.CCOC(=O)CCCBr.CCOC(C)=O.Cc1ccc(S)cc1.O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CCCSc1ccc(C)cc1",
        "output": "124"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)c1ccc(N)cc1.CCOC(C)=O.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.Cc1cccc(C)c1-c1cc2ccc(C(=O)O)cc2[nH]1.F[P-](F)(F)(F)(F)F>>Cc1cccc(C)c1-c1cc2ccc(C(=O)Nc3ccc(C(C)(C)C)cc3)cc2[nH]1",
        "output": "50"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCC(=S)NCC(=O)OC.CO.N>>CCCC(=S)NCC(N)=O",
        "output": "432"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC(=O)NC[C@H]1CN(c2ccc(N3CCC(=O)C(C)(C)C3)c(F)c2)C(=O)O1.CO.[BH4-].[Na+]>>CC(=O)NC[C@H]1CN(c2ccc(N3CCC(O)C(C)(C)C3)c(F)c2)C(=O)O1",
        "output": "91"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "C#C[C@]1(O)CCN(C)C1=O.Cc1cc(Br)cc(-c2nccc(C(N)=O)n2)c1>>Cc1cc(C#C[C@]2(O)CCN(C)C2=O)cc(-c2nccc(C(N)=O)n2)c1",
        "output": "659"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Brc1ccc(-c2c[nH]c(C3CC3)n2)cc1.C1CCOC1.CI.O.O=C([O-])[O-].[Cs+].[Cs+]>>Cn1cc(-c2ccc(Br)cc2)nc1C1CC1",
        "output": "404"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCO.CO.Cl.N#Cc1c[nH]c2nccc(Cc3ccc(N)cc3F)c12.Nc1nccc(Cl)n1.O.[Na+].[OH-]>>N#Cc1c[nH]c2nccc(Cc3ccc(Nc4ccnc(N)n4)cc3F)c12",
        "output": "161"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(N)c1ccccc1.CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4CCC(=O)O)cc3)cc2)CC1>>CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4CCC(=O)NC(C)(C)c4ccccc4)cc3)cc2)CC1",
        "output": "599"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOCC.CI.CN(C)C=O.COc1cc(C=O)cc([N+](=O)[O-])c1O.O=C([O-])[O-].[Cs+].[Cs+]>>COc1cc(C=O)cc([N+](=O)[O-])c1OC",
        "output": "62"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "COCCCCC(O)(c1cccc(Cl)c1)[C@@H]1CCCN(C(=O)C[C@@H](CC2CCCCC2)CN(C)C(=O)OC(C)(C)C)C1.ClCCl.O=C(O)C(F)(F)F>>CNC[C@@H](CC(=O)N1CCC[C@@H](C(O)(CCCCOC)c2cccc(Cl)c2)C1)CC1CCCCC1",
        "output": "575"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "BrB(Br)Br.CCOC(=O)N1C2CCC1CC(c1ccnc3c(-c4cccc(OC)c4)c(-c4ccncc4)nn13)C2.ClCCl>>CCOC(=O)N1C2CCC1CC(c1ccnc3c(-c4cccc(O)c4)c(-c4ccncc4)nn13)C2",
        "output": "48"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CCC(C)N.CCCCO.Nc1nc(Cl)nc2c1ncn2Cc1ccccc1.[Na+].[OH-]>>CCC(C)Nc1nc(N)c2ncn(Cc3ccccc3)c2n1",
        "output": "578"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCN(CC)CC.CN(C)C(=O)Cl.COC(COc1cc(C)cc(O)c1)OC.Cc1ccccc1C>>COC(COc1cc(C)cc(OC(=O)N(C)C)c1)OC",
        "output": "425"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)CC[C@@H]1CC[C@@H](n2cc3ccc(OCC4CC4)cc3n2)CC1.CCO.[BH4-].[Na+]>>CC(O)CC[C@@H]1CC[C@@H](n2cc3ccc(OCC4CC4)cc3n2)CC1",
        "output": "91"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CCOC(=O)c1cnc(Nc2ccc(-c3ccccc3)cc2)[nH]c1=O.CO.[Na+].[OH-]>>O=C(O)c1cnc(Nc2ccc(-c3ccccc3)cc2)[nH]c1=O",
        "output": "171"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.COC(=O)/C=C(C)/C=C/C(F)=C(C)/C=C/c1c(C)sc(C)c1C.Cl.O.[Na+].[OH-]>>CC(/C=C/C(F)=C(C)/C=C/c1c(C)sc(C)c1C)=C\\C(=O)O",
        "output": "58"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(=O)O.ClCCl.NCc1ccccc1.O=C(O)c1sccc1O.O=C([O-])O.[Na+]>>O=C(NCc1ccccc1)c1sccc1O",
        "output": "950"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)CCCC1(c2ccccc2)CCCCC1.CO.Cl.[Na+].[OH-]>>O=C(O)CCCC1(c2ccccc2)CCCCC1",
        "output": "7"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(CC)CC.CN(C)C=O.CN(C)CCN.F[P-](F)(F)(F)(F)F.O.O=C(O)c1n[nH]c2cc([N+](=O)[O-])ccc12.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>>CN(C)CCNC(=O)c1n[nH]c2cc([N+](=O)[O-])ccc12",
        "output": "816"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cc1nc(NC(=O)C(C)(C)C)ccc1CO.Fc1ccc(CBr)cc1>>Cc1nc(NC(=O)C(C)(C)C)ccc1COCc1ccc(F)cc1",
        "output": "464"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)N(CCCCOCC(=O)OC(C)(C)C)c1cnc(-c2ccccc2)c(-c2ccccc2)n1.CO.[Na+].[OH-]>>CC(C)N(CCCCOCC(=O)O)c1cnc(-c2ccccc2)c(-c2ccccc2)n1",
        "output": "278"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrBr.COc1ccc(-c2noc3ccccc23)c(OC)c1.ClC(Cl)Cl>>COc1cc(OC)c(-c2noc3ccccc23)cc1Br",
        "output": "98"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)CC1Cc2ccc(C(=O)O)cc2Cc2ccccc21.CN(C)C=O.CNCc1nc2ccccc2[nH]1.Cl.Cl.ClCCCl.O.On1nnc2ccccc21>>CCOC(=O)CC1Cc2ccc(C(=O)N(C)Cc3nc4ccccc4[nH]3)cc2Cc2ccccc21",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCOC(C)=O.COC(=O)Nc1ccc(NCC2CCC(F)(F)CC2)c([N+](=O)[O-])c1.FSI.[Pd]>>COC(=O)Nc1ccc(NCC2CCC(F)(F)CC2)c(N)c1",
        "output": "1"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "ClCCl.O=C1c2ccccc2-n2cnc(CO)c2[C@@H]2CCCN12.[Mn+4].[O-2].[O-2]>>O=Cc1ncn2c1[C@@H]1CCCN1C(=O)c1ccccc1-2",
        "output": "287"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "C=C(C)c1ccc(OC(C)C(=O)O)cc1.CC(Oc1ccc(O)cc1)C(=O)O.CO.OO>>COC(=O)C(C)Oc1ccc(O)cc1",
        "output": "195"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CN.Cc1ccccc1.O.O=Cc1cc2c(N3CCOCC3)nc(Cl)nc2s1>>CNCc1cc2c(N3CCOCC3)nc(Cl)nc2s1",
        "output": "691"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "BrCC1CC1.CC(=O)N(c1ccccc1)C1(c2nc(C)cs2)CCNCC1.CCOC(C)=O.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CC(=O)N(c1ccccc1)C1(c2nc(C)cs2)CCN(CC2CC2)CC1",
        "output": "73"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CN(C2CCOCC2)CCN1.CCN(C(C)C)C(C)C.CCc1nccc(-c2ccc(C(=O)O)c(F)c2)c1C#Cc1ccc(N)nc1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CO.F[P-](F)(F)(F)(F)F.O>>CCc1nccc(-c2ccc(C(=O)N3CCN(C4CCOCC4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "BrBr.CCOCC.COc1ccc2c(c1)C(=O)CCC2>>COc1ccc2c(c1)C(=O)C(Br)CC2",
        "output": "82"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(C(C)C)C(C)C.CN1CCN(c2ccc3nc(-c4n[nH]c5cccc(N)c45)[nH]c3c2)CC1.ClCCl.O=C(Cl)c1ccccc1>>CN1CCN(c2ccc3nc(-c4n[nH]c5cccc(NC(=O)c6ccccc6)c45)[nH]c3c2)CC1",
        "output": "11"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C1CNCCN1.CC(C)(C)O.CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.O.[Na+].[OH-]>>CC(C)(C)OC(=O)N1CCNCC1",
        "output": "694"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCCCCC.CCO.CCOC(C)=O.COC(=O)Cc1ccncc1C#N.[BH4-].[Na+]>>N#Cc1cnccc1CCO",
        "output": "343"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCCCc1nc2ccc(NC(=O)C3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1.O=C(O)C(F)(F)F>>CCCCc1nc2ccc(NC(=O)C3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1",
        "output": "752"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCCCNCC.CS(C)=O.Cc1cc(C)c(-n2cc(C)c3c(Cl)nc(C)nc32)c(C)c1.Cl.O>>CCCCN(CC)c1nc(C)nc2c1c(C)cn2-c1c(C)cc(C)cc1C",
        "output": "540"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1C[C@@H](N)[C@@H](F)C1.COc1ccc(C[C@H]2NC(=O)n3c2nc2ccccc23)cc1>>COc1ccc(C[C@@H](NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)C[C@@H]2F)c2nc3ccccc3[nH]2)cc1",
        "output": "999"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CCOC(=O)c1c(C2CC2)nc(-c2cccnc2)n1Cc1cccc2ccccc12.CO.Cl.[Na+].[OH-]>>O=C(O)c1c(C2CC2)nc(-c2cccnc2)n1Cc1cccc2ccccc12",
        "output": "171"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.COc1ccc2c(OCCBr)ccnc2c1.O.O=C([O-])[O-].O=c1ccc(Cl)n[nH]1.[K+].[K+]>>COc1ccc2c(OCCn3nc(Cl)ccc3=O)ccnc2c1",
        "output": "577"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC#N.CCOC(C)=O.COC(=O)C1(c2ccc(N)cc2)CCOCC1.ClCCl.O=C1CCC(=O)N1Br>>COC(=O)C1(c2ccc(N)c(Br)c2)CCOCC1",
        "output": "4"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(c1cccc([N+](=O)[O-])c1)n1c(=O)oc2cc(F)c(F)cc21.[Ni]>>CC(c1cccc(N)c1)n1c(=O)oc2cc(F)c(F)cc21",
        "output": "71"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(=O)N1CCC(Nc2ccccc2[N+](=O)[O-])CC1.CO.[Pd]>>CCOC(=O)N1CCC(Nc2ccccc2N)CC1",
        "output": "1"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C(=O)O)C(F)(F)F.CCN(C(C)C)C(C)C.CCOCC.CN(C)C=O.CNOC.Cl.ClCCl.O=C(Cl)C(=O)Cl>>CON(C)C(=O)C(C)(C)C(F)(F)F",
        "output": "54"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCNC1.O=C(O)CCc1ccc(Br)cc1>>O=C(CCc1ccc(Br)cc1)N1CCCC1",
        "output": "146"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCN(CC)CC.CC[Si](CC)(CC)c1cc(Br)nc([C@]2(C)C[S@@](=O)(=NCCO)C(C)(C)C(NC(=O)OC(C)(C)C)=N2)c1F.CN(C)c1ccncc1.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O>>CC[Si](CC)(CC)c1cc(Br)nc([C@]2(C)C[S@@](=O)(=NCCOS(=O)(=O)c3ccc(C)cc3)C(C)(C)C(NC(=O)OC(C)(C)C)=N2)c1F",
        "output": "197"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(C(C)C)C(C)C.Cc1cccc(N2CCNCC2)c1C.O=CCCc1cc(-c2ccccc2)n(-c2ccccc2)n1.[Na+]>>Cc1cccc(N2CCN(CCCc3cc(-c4ccccc4)n(-c4ccccc4)n3)CC2)c1C",
        "output": "484"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)(N)COc1cccc2c1C(N)=NS(=O)(=O)N2.Cc1cc(C(=O)O)ccn1.Cl>>Cc1cc(C(=O)NC(C)(C)COc2cccc3c2C(N)=NS(=O)(=O)N3)ccn1",
        "output": "334"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.COC(=O)Cl.O.O=S(=O)(C=C1CN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C1)Cc1cccc(N2CCNCC2)c1.c1ccncc1>>COC(=O)N1CCN(c2cccc(CS(=O)(=O)C=C3CN(C(c4ccc(Cl)cc4)c4ccc(Cl)cc4)C3)c2)CC1",
        "output": "219"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Fc1ccc(-n2nc3c(c2Cl)CCCC3)c(F)c1.O=S(=O)(O)O.O=[N+]([O-])O>>O=[N+]([O-])c1cc(-n2nc3c(c2Cl)CCCC3)c(F)cc1F",
        "output": "21"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CC1NCCc2c(C(=O)N(C)C)cccc21.O=C(O)c1cc2ncc(Cl)cn2n1>>CC1c2cccc(C(=O)N(C)C)c2CCN1C(=O)c1cc2ncc(Cl)cn2n1",
        "output": "952"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "COc1ccc(COCC[C@H](O)CO)cc1.ClC(c1ccccc1)(c1ccccc1)c1ccccc1.c1ccncc1>>COc1ccc(COCC[C@H](O)COC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1",
        "output": "250"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CC(C)(C)OC(=O)N1CCC(CBr)(c2ccc(Br)cc2)CC1.CN(C)C=O.COc1cccc(O)c1.ClCCl.O=C([O-])[O-].[Cs+].[Cs+]>>COc1cccc(OCC2(c3ccc(Br)cc3)CCN(C(=O)OC(C)(C)C)CC2)c1",
        "output": "75"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNC1.ClCCl.O=S(=O)(Cl)c1ccc(Br)c(F)c1>>O=S(=O)(c1ccc(Br)c(F)c1)N1CCCC1",
        "output": "99"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CO.ClC(Cl)Cl.Fc1ccc(N2CCNCC2)cc1.O=C([O-])[O-].O=C1CSCN1CCCCBr.[Br-].[I-].[K+].[K+].[Na+]>>O=C1CSCN1CCCCN1CCN(c2ccc(F)cc2)CC1",
        "output": "73"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCc1ccccc1O.CN(C)C=O.O=C([O-])[O-].O=[N+]([O-])c1ccc(Cl)nc1.[K+].[K+]>>CCc1ccccc1Oc1ccc([N+](=O)[O-])cn1",
        "output": "516"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCOCC.COC(=O)C1CCC(O[Si](C)(C)C(C)(C)C)CC1.O.[Al+3].[H-].[H-].[H-].[H-].[K+].[Li+].[OH-]>>CC(C)(C)[Si](C)(C)OC1CCC(CO)CC1",
        "output": "343"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOCC.CO.O=C(O)c1cc(Cl)cnc1Cl.O=S(Cl)Cl>>COC(=O)c1cc(Cl)cnc1Cl",
        "output": "195"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CN(C)C=O.CNc1cc(C(C)=O)ccc1O.ClCCCBr.[H-].[Na+]>>CNc1cc(C(C)=O)ccc1OCCCCl",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCc1nc2c(C)cc(C)nc2n1Cc1cc(C)c(OC(C(=O)OC)c2cccc(Cl)c2)c(C)c1.CO.Cl.[Na+].[OH-]>>CCc1nc2c(C)cc(C)nc2n1Cc1cc(C)c(OC(C(=O)O)c2cccc(Cl)c2)c(C)c1",
        "output": "88"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CN(C)C=O.Clc1cccnc1-n1cccc1.O=P(Cl)(Cl)Cl.[Na+].[OH-]>>O=Cc1cccn1-c1ncccc1Cl",
        "output": "641"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "Br.COc1cccc(C2CCNCC2)c1>>Oc1cccc(C2CCNCC2)c1",
        "output": "48"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCO.Nc1cc(C(=O)O)cc([N+](=O)[O-])c1.O=S(=O)(O)O>>CCOC(=O)c1cc(N)cc([N+](=O)[O-])c1",
        "output": "33"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COc1cccc(F)c1C(=O)Cl.Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1.O=C1CC(=O)N(CCNC(=O)c2ccccc2I)c2ccc3ccccc3c2N1>>COc1cccc(F)c1C(=O)Nc1ccc(N2C(=O)CC(=O)Nc3c2ccc2ccccc32)cc1",
        "output": "11"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CC[C@@H](N)[C@H](O[Si](C)(C)C(C)(C)C)C1.ClCCl.O=C(Cl)CCCCl>>CC(C)(C)OC(=O)N1CC[C@@H](NC(=O)CCCCl)[C@H](O[Si](C)(C)C(C)(C)C)C1",
        "output": "45"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cc1ccc(S(=O)(=O)n2ccc3c(NC4CCCCNC4)ncnc32)cc1.O=C(O)CNc1cc(Cl)cc(Cl)c1.On1nnc2ccccc21>>Cc1ccc(S(=O)(=O)n2ccc3c(NC4CCCCN(C(=O)CNc5cc(Cl)cc(Cl)c5)C4)ncnc32)cc1",
        "output": "146"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC#N.CC(C)(C)OC(=O)N1CCN(c2c(C=O)c3cccnc3n2-c2cccnc2)CC1.CCOCC.ClCCl.O=C(O)C(F)(F)F>>O=Cc1c(N2CCNCC2)n(-c2cccnc2)c2ncccc12",
        "output": "575"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "BrC(Br)(Br)Br.CCOCC.OCc1cc(Cl)ccc1F.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Fc1ccc(Cl)cc1CBr",
        "output": "750"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CC(=O)O.CO.O=C1CCC(=O)N1Br.c1ccc(-n2c3ccccc3c3ccccc32)cc1>>Brc1ccc2c(c1)c1ccccc1n2-c1ccccc1",
        "output": "4"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCN(C(C)C)C(C)C.CCOC(=O)C1CCOc2c1cc(Cl)c(Oc1ccc(C(=O)O)cc1)c2Cl.CN(C)C=O.ClCCl.NCCc1ccc(Cl)cc1.O=C(Cl)C(=O)Cl>>CCOC(=O)C1CCOc2c1cc(Cl)c(Oc1ccc(C(=O)NCCc3ccc(Cl)cc3)cc1)c2Cl",
        "output": "334"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCC2=NCCCN2CC1.CCCCO.CCN(CC)CC.CCc1c(C)nc(-c2cccs2)nc1Cl.Cl.NCCc1ccc(C(=O)O)cc1>>CCc1c(C)nc(-c2cccs2)nc1NCCc1ccc(C(=O)O)cc1",
        "output": "166"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN1CCCC1=O.COc1ccc(-c2cnc(Nc3ccccc3)nc2)cc1F.O.O=C([O-])[O-].Sc1ccccc1.[K+].[K+]>>Oc1ccc(-c2cnc(Nc3ccccc3)nc2)cc1F",
        "output": "48"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCO.CCOC(=O)c1c(-c2ccc(OC)cc2)c2cccnc2n1Cc1ccc2c(c1)OCO2.O.[Na+].[OH-]>>COc1ccc(-c2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3ncccc23)cc1",
        "output": "171"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CO.Clc1cc(-n2ccnc2)ncn1.[Na]>>COc1cc(-n2ccnc2)ncn1",
        "output": "653"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CC#N.CCN(C(C)C)C(C)C.CCOC(C)=O.CN(C)C(On1nnc2ccccc21)=[N+](C)C.COc1cnc(-n2c(=S)[nH]c3cc(C(=O)O)ccc3c2=O)c(OC)c1.F[B-](F)(F)F.NCc1cccc(Cl)c1>>COc1cnc(-n2c(=S)[nH]c3cc(C(=O)NCc4cccc(Cl)c4)ccc3c2=O)c(OC)c1",
        "output": "753"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C1CNCCN1.Clc1cncc(OCc2ccc(OCc3ccccc3)cc2)n1.O=C([O-])[O-].OCc1ccc(OCc2ccccc2)cc1.[K+].[K+]>>c1ccc(COc2ccc(COc3cncc(N4CCNCC4)n3)cc2)cc1",
        "output": "505"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C1COCCO1.CC(C)(C)OC(=O)N(Cc1ccc(C(=O)Nc2ccc(CN(C(=O)OCc3ccccc3)C3CCCCC3)cc2)cc1)Cc1ncc[nH]1.CO.Cl>>O=C(Nc1ccc(CN(C(=O)OCc2ccccc2)C2CCCCC2)cc1)c1ccc(CNCc2ncc[nH]2)cc1",
        "output": "887"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN.CO.Cn1cc(C=O)c2ccccc21.[BH4-].[Na+]>>CNCc1cn(C)c2ccccc12",
        "output": "441"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.Cc1cc(-c2ccccc2)cn1CCO.Cc1ccc(S(=O)(=O)Cl)cc1.ClCCl.O>>Cc1ccc(S(=O)(=O)OCCn2cc(-c3ccccc3)cc2C)cc1",
        "output": "197"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C=CCNC(=O)OC(C)(C)C.CC(=O)[O-].CC(=O)[O-].CCCC(CCC)C(=O)Nc1cccc(Br)c1.CCN(CC)CC.CN(C)C=O.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.[Pd+2]>>CCCC(CCC)C(=O)Nc1cccc(/C=C/CNC(=O)OC(C)(C)C)c1",
        "output": "539"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCC2=NCCCN2CC1.CC#N.CC(C)(C)[Si](C)(C)Cl.COc1cc(-c2ccc(N)c3c2CNC3=O)ccc1O.O>>COc1cc(-c2ccc(N)c3c2CNC3=O)ccc1O[Si](C)(C)C(C)(C)C",
        "output": "746"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Cn1ccnc1Sc1ccc(N)cc1Cl.O=[N+]([O-])c1ccc(O)cc1F>>Nc1ccc(O)cc1F",
        "output": "1"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cc1ccccc1.O=C(O)Cc1c(Cl)cccc1Cl.O=S(Cl)Cl>>O=C(Cl)Cc1c(Cl)cccc1Cl",
        "output": "53"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "BrB(Br)Br.COc1ccc(-c2ccc(=O)n(C)n2)cc1.ClCCl>>Cn1nc(-c2ccc(O)cc2)ccc1=O",
        "output": "48"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC#N.Cc1ccc(S(=O)(=O)OCCCCc2c[nH]c3ccc(F)cc23)cc1.O=C([O-])[O-].O=c1ccccn1-c1ccc(N2CCNCC2)cc1.[I-].[K+].[K+].[K+]>>O=c1ccccn1-c1ccc(N2CCN(CCCCc3c[nH]c4ccc(F)cc34)CC2)cc1",
        "output": "429"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCCCOc1ccc2c(c1-c1ncnc3c(C(=O)NC4CCCNC4)c[nH]c13)OCO2.COCC(=O)Cl>>CCCCOc1ccc2c(c1-c1ncnc3c(C(=O)NC4CCCN(C(=O)COC)C4)c[nH]c13)OCO2",
        "output": "125"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)OC(=O)N(Cc1ccc([N+](=O)[O-])cc1)Cc1ncc[nH]1.CCO.[C].[Pd]>>CC(C)(C)OC(=O)N(Cc1ccc(N)cc1)Cc1ncc[nH]1",
        "output": "507"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CC(C)(C)OC(=O)NCC(O)CN.CS(=O)(=O)OCCNC(=O)OCc1ccccc1.O=C([O-])[O-].[K+].[K+]>>CC(C)(C)OC(=O)NCC(O)CNCCNC(=O)OCc1ccccc1",
        "output": "559"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1.CCN(C(C)C)C(C)C.CCO.CNC.Cl.O=C(O)COC1CCc2c(-c3ccc(C(F)(F)F)cc3)cncc21>>CN(C)C(=O)COC1CCc2c(-c3ccc(C(F)(F)F)cc3)cncc21",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CS(=O)(=O)c1cccc(Nc2cc(-c3ccccc3OCc3ccccc3)ncn2)c1.O=C(O)C(F)(F)F>>CS(=O)(=O)c1cccc(Nc2cc(-c3ccccc3O)ncn2)c1",
        "output": "23"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C=CC(=O)Cl.OC12CC3CC(CC(C3)C1)C2>>C=CC(=O)OC12CC3CC(CC(C3)C1)C2",
        "output": "320"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC#N.CCOC(=O)CCn1cnc2c(=O)[nH]cnc21.CCOCC.CO.NCCCN>>NCCCNC(=O)CCn1cnc2c(=O)[nH]cnc21",
        "output": "64"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C=[N+]=[N-].CCOCC.CO.Nc1c(I)cccc1C(=O)O>>COC(=O)c1cccc(I)c1N",
        "output": "60"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "COCC(=O)Cl.COCCOc1cc(OC)ccc1-c1ncnc2c(C(=O)N[C@@H]3CC[C@@H](N)CC3)c[nH]c12>>COCCOc1cc(OC)ccc1-c1ncnc2c(C(=O)N[C@@H]3CC[C@@H](NC(=O)COC)CC3)c[nH]c12",
        "output": "45"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CNC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.COCc1noc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)O)c(F)c3)CC2)n1.F[P-](F)(F)(F)(F)F>>COCc1noc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)N4CCC4)c(F)c3)CC2)n1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc(-c2ccc(C(=O)O)[nH]2)c1.C[C@@H](O)[C@@H](N)CO.Cl.O.O.On1nnc2ccccc21.[Cl-].[Na+]>>COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc(-c2ccc(C(=O)N[C@@H](CO)[C@@H](C)O)[nH]2)c1",
        "output": "137"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NC(CC(=O)O)c1ccc(OC(F)(F)F)cc1.CCN=C=NCCCN(C)C.CN(C)C=O.Cl.O.On1nnc2ccccc21.[NH4+]>>CC(C)(C)OC(=O)NC(CC(N)=O)c1ccc(OC(F)(F)F)cc1",
        "output": "313"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "Cc1cc(Cl)ccc1C(N)c1ccccc1.Cc1ncccc1N1CCc2cc(CC(=O)O)ccc2C1=O>>Cc1cc(Cl)ccc1C(NC(=O)Cc1ccc2c(c1)CCN(c1cccnc1C)C2=O)c1ccccc1",
        "output": "769"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CO.Cc1cc(S(N)(=O)=O)ccc1N.O=C(O)c1cc(N(CC2CC2)C2CCCCC2)ncn1>>Cc1cc(S(N)(=O)=O)ccc1NC(=O)c1cc(N(CC2CC2)C2CCCCC2)ncn1",
        "output": "548"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1CCOC1.Cl.N#Cc1c(F)cc(CN=[N+]=[N-])cc1F.O.[BH4-].[Na+].[Pd]>>N#Cc1c(F)cc(CN)cc1F",
        "output": "562"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrC(Br)(Br)Br.ClCCl.O=C(NC1CC1)c1cn(-c2cccc(-c3ccc(CO)cc3)c2)c2ncccc2c1=O.c1ccc(P(CCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1>>O=C(NC1CC1)c1cn(-c2cccc(-c3ccc(CBr)cc3)c2)c2ncccc2c1=O",
        "output": "750"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC#N.Nc1ccc(C2CCOCC2)cn1.O=C1CCC(=O)N1Br>>Nc1ncc(C2CCOCC2)cc1Br",
        "output": "518"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)O.CC(=O)[O-].CC(C)Nc1ncnc2cc(O)c(C=O)cc12.Cl.NO.O.[Na+]>>CC(C)Nc1ncnc2cc(O)c(C#N)cc12",
        "output": "453"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COC(=O)CC1Cc2ccc(OCCCCNC(=N)N)cc2NC1=O.COC(=O)Cc1cc2ccc(OCCCNC(=N)N)cc2n(Cc2ccccc2)c1=O.O=C(O)C(F)(F)F>>N=C(N)NCCCOc1ccc2cc(CC(=O)O)c(=O)n(Cc3ccccc3)c2c1",
        "output": "88"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CCN(C(C)C)C(C)C.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=c1[nH]cc(F)c2cc(Br)ccc12.SCc1ccccc1.[Pd].[Pd]>>O=c1[nH]cc(F)c2cc(SCc3ccccc3)ccc12",
        "output": "824"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)[O-].CC(C)(C)OC(=O)N1CCC(=O)c2cc(C(F)(F)F)ccc21.CCO.[BH3-]C#N.[NH4+].[Na+]>>CC(C)(C)OC(=O)N1CCC(N)c2cc(C(F)(F)F)ccc21",
        "output": "552"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CONC(=O)c1cc(N2CCC(NC(=O)c3[nH]c(C)c(Cl)c3Cl)CC2)nc(SC)n1.ClCCl.O=C(OO)c1cccc(Cl)c1>>CONC(=O)c1cc(N2CCC(NC(=O)c3[nH]c(C)c(Cl)c3Cl)CC2)nc(S(C)=O)n1",
        "output": "595"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CCN(CC)CC.ClCCl.O.O=C(Cl)N1CCOCC1.O=C(NC1CNCC(c2ccc(C(F)(F)F)cc2)C1)c1ccccc1>>O=C(NC1CC(c2ccc(C(F)(F)F)cc2)CN(C(=O)N2CCOCC2)C1)c1ccccc1",
        "output": "258"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C=O.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CO.C[C@@H]1CN(c2ccc(Nc3cc(Br)cn(C)c3=O)nc2)CCN1.O.[Na+]>>C[C@@H]1CN(c2ccc(Nc3cc(Br)cn(C)c3=O)nc2)CCN1C",
        "output": "217"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.Cc1ccc(S(=O)(=O)O)cc1.N[C@@H]1CCOC1.O=C=NCCCl.[H-].[Na+]>>O=C(NCCCl)N[C@@H]1CCOC1",
        "output": "244"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN(C(C)C)C(C)C.CCO.N#Cc1ccc(Cl)nn1.c1cc2c(ncc3[nH]nc(C4CCCNC4)c32)[nH]1>>N#Cc1ccc(N2CCCC(c3n[nH]c4cnc5[nH]ccc5c34)C2)nn1",
        "output": "406"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "BrB(Br)Br.COc1ccc(Cl)cc1-c1c(O)c(=O)[nH]c2cc(Cl)cc(Cl)c12.ClCCl.O>>O=c1[nH]c2cc(Cl)cc(Cl)c2c(-c2cc(Cl)ccc2O)c1O",
        "output": "48"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "COc1cc(C=O)ccc1O.CS(C)=O.N#Cc1ccc(F)cc1.O.O=C([O-])[O-].[Li+].[Li+]>>COc1cc(C=O)ccc1Oc1ccc(C#N)cc1",
        "output": "564"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCOC1.CC(=O)OI1(OC(C)=O)(OC(C)=O)OC(=O)c2ccccc21.Cc1c(CO)cn2ncnc(Oc3ccc(NC(=O)CC(=O)Nc4ccc(F)cc4)cc3F)c12>>Cc1c(C=O)cn2ncnc(Oc3ccc(NC(=O)CC(=O)Nc4ccc(F)cc4)cc3F)c12",
        "output": "520"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CN(C)C(On1nnc2cccnc21)=[N+](C)C.CN(C)C=O.CN1CCOCC1.COc1cc(-c2cn3c(-c4ccc(C#N)cc4)cnc3cn2)ccc1C(=O)O.F[P-](F)(F)(F)(F)F.O>>COc1cc(-c2cn3c(-c4ccc(C#N)cc4)cnc3cn2)ccc1C(=O)N1CCN(C(=O)OC(C)(C)C)CC1",
        "output": "44"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CCN(CC)CC.CN(C)C=O.CNCCN(C)C.COc1ccc(Cn2nnnc2/C=C/c2c(N3CCCC(CC(=O)O)C3)nc3cc(C(=O)Nc4nc(C(C)(C)C)cs4)ccn3c2=O)cc1.Cl.ClCCl.On1nnc2ccccc21>>COc1ccc(Cn2nnnc2/C=C/c2c(N3CCCC(CC(=O)N(C)CCN(C)C)C3)nc3cc(C(=O)Nc4nc(C(C)(C)C)cs4)ccn3c2=O)cc1",
        "output": "146"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CC(C)(C)c1ccc(S(=O)(=O)Cl)cc1.Cn1cc(C(=O)c2cc(Cl)ccc2N)nn1.c1ccncc1>>Cn1cc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nn1",
        "output": "68"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC#N.CCCN.CCN(CC)CC.N#Cc1cnc(Nc2ccccc2)nc1Cl.O>>CCCNc1nc(Nc2ccccc2)ncc1C#N",
        "output": "110"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1cc(F)ccc1-n1ccc2c(Cl)nc3c(OCC(F)(F)F)cccc3c21.NCCO>>Cc1cc(F)ccc1-n1ccc2c(NCCO)nc3c(OCC(F)(F)F)cccc3c21",
        "output": "110"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.C1COCCO1.CC(C)c1ccc2c(Nc3cc(C(=O)Nc4ccc(-c5c[nH]c([C@@H]6CCCN6C(=O)Cc6ccccc6)n5)cc4)ccc3Sc3ccc(NC(=O)OC(C)(C)C)cc3)ncnc2n1.Cl>>CC(C)c1ccc2c(Nc3cc(C(=O)Nc4ccc(-c5c[nH]c([C@@H]6CCCN6C(=O)Cc6ccccc6)n5)cc4)ccc3Sc3ccc(N)cc3)ncnc2n1",
        "output": "782"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CC(=O)[O-].CCCCCCc1cc2c(cc1OCCCC(=O)O)C(=O)CC2.CCO.Cl.NO.[Na+]>>CCCCCCc1cc2c(cc1OCCCC(=O)O)C(=NO)CC2",
        "output": "212"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CC1(COc2cc(F)c(C(=O)NS(C)(=O)=O)cc2C2CC2)CN(C(=O)OC(C)(C)C)C1.O=Cc1cc(Cl)cc(Cl)c1>>CC1(COc2cc(F)c(C(=O)NS(C)(=O)=O)cc2C2CC2)CN(Cc2cc(Cl)cc(Cl)c2)C1",
        "output": "935"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3ccncc3)c2)cc1-c1ccccc1F.ClCCl.O=C(O)C(F)(F)F>>CN(C)c1cc2c(cc1-c1ccccc1F)NC(=O)CC(c1cccc(-c3ccncc3)c1)=N2",
        "output": "930"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)(C)OC(=O)N1CC(N)C2(CCCC2)C1.CCN(CC)CC.CCO.Clc1ccnc(Cl)n1>>CC(C)(C)OC(=O)N1CC(Nc2ccnc(Cl)n2)C2(CCCC2)C1",
        "output": "166"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCO.COCCN(Cc1cnc(-c2cc3nccc(Oc4ccc(N)cc4F)c3s2)n1C)C(=O)OC(C)(C)C.Cc1ccccc1.O=C(Cc1ccccc1)N=C=S>>COCCN(Cc1cnc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4F)c3s2)n1C)C(=O)OC(C)(C)C",
        "output": "961"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "BrBr.Cc1ccc(O)c(C(=O)c2ccccc2)c1.ClCCl.O.[Fe]>>Cc1cc(Br)c(O)c(C(=O)c2ccccc2)c1",
        "output": "98"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)CCO.CNCCO.Cl.Clc1ccncc1.O=C([O-])O.[Na+]>>CN(CCO)c1ccncc1",
        "output": "398"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cc1cccc(F)n1.O.O=C([O-])[O-].O=C1CCCc2cc(O)ccc21.[Cs+].[Cs+]>>Cc1cccc(Oc2ccc3c(c2)CCCC3=O)n1",
        "output": "727"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "COc1ccc2c(=O)[nH]c(C#N)c(-c3ccccc3)c2c1.O=P(Cl)(Cl)Cl>>COc1ccc2c(Cl)nc(C#N)c(-c3ccccc3)c2c1",
        "output": "100"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "C1COCCO1.CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(B3OC(C)(C)C(C)(C)O3)cc12.Cl[Pd]Cl.FC(COCc1ccccc1)c1ccc(Br)nc1Cl.O.O=C([O-])[O-].[Fe+2].[K+].[K+].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1>>CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(C)S(C)(=O)=O)c(-c3ccc(C(F)COCc4ccccc4)c(Cl)n3)cc12",
        "output": "939"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)[O-].CC(=O)[O-].CCO.Cc1ccccc1.Cc1ccccc1P(c1ccccc1C)c1ccccc1C.Nc1ccc(Br)cc1.OB(O)c1cccc2ccccc12.[Pd+2]>>Nc1ccc(-c2cccc3ccccc23)cc1",
        "output": "837"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCN(CC)CC.CN1CCN(c2cccc3ccc(O)cc23)CC1.ClCCl.O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>>CN1CCN(c2cccc3ccc(OS(=O)(=O)C(F)(F)F)cc23)CC1",
        "output": "731"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC1CCNCC1.CCO.O=[N+]([O-])c1ccc(Cl)nc1Cl>>CC1CCN(c2nc(Cl)ccc2[N+](=O)[O-])CC1",
        "output": "220"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)(C)OC(=O)N1CCNCC1.CC(C)(C)[O-].Cc1cc(C)c(Br)cc1C.Cc1ccccc1.O.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Na+].[Pd].[Pd].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1>>Cc1cc(C)c(N2CCN(C(=O)OC(C)(C)C)CC2)cc1C",
        "output": "294"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CN1CCNCC1.O=C(O)c1ccc(-c2cnc3c(c2)N(Cc2c(F)ccc(F)c2Cl)C(=O)CN3)cc1>>CN1CCN(C(=O)c2ccc(-c3cnc4c(c3)N(Cc3c(F)ccc(F)c3Cl)C(=O)CN4)cc2)CC1",
        "output": "44"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "C[C@H]1CN(c2ccc(OCCCN3CCCCC3)cc2)CCN1.N#Cc1ccc(C(=O)O)cc1>>C[C@H]1CN(c2ccc(OCCCN3CCCCC3)cc2)CCN1C(=O)c1ccc(C#N)cc1",
        "output": "44"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=CC(=O)Cl.CC#N.CCN(CC)CC.ClCCl.NCCn1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc21.O>>C=CC(=O)NCCn1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc21",
        "output": "298"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1CCOC1.CCOC(=O)C(CNC(=O)OC(C)(C)C)Cc1ccc(Cl)c(F)c1.CO.O.O.[Li]O>>CC(C)(C)OC(=O)NCC(Cc1ccc(Cl)c(F)c1)C(=O)O",
        "output": "7"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.C[C@H](N)c1ncc(F)cn1.Cl.Clc1nc(Cl)nc(Nc2cn(CCc3ccsc3)cn2)n1>>C[C@H](Nc1nc(Cl)nc(Nc2cn(CCc3ccsc3)cn2)n1)c1ncc(F)cn1",
        "output": "578"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "CCOC(=O)C(C)N1C(=O)CCc2ccc(-n3c(C)ccc3C)cc21.COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1.Cc1ccccc1>>CCOC(=O)C(C)N1C(=S)CCc2ccc(-n3c(C)ccc3C)cc21",
        "output": "695"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CCN=C=NCCCN(C)C.CCO.CN(C)c1ccncc1.Cl.ClCCl.O=C(O)Cc1ccc(I)c(OCC(F)(F)F)c1>>CCOC(=O)Cc1ccc(I)c(OCC(F)(F)F)c1",
        "output": "47"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "Nc1cccc2c1cnn2CCN1CCCC1.O=C(O)CCc1ccc(Oc2ccccc2)cc1>>O=C(CCc1ccc(Oc2ccccc2)cc1)Nc1cccc2c1cnn2CCN1CCCC1",
        "output": "365"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "C1CCOC1.CCOC(C)=O.CN(C)C=O.Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1.O=C(CCl)Nc1cccc2ccccc12.O=C([O-])[O-].[K+].[K+]>>O=C(CN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Nc1cccc2ccccc12",
        "output": "340"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "Cc1cccc(-c2ccc3c(c2)CCCC3=O)c1.[BH4-].[Na+]>>Cc1cccc(-c2ccc3c(c2)CCCC3O)c1",
        "output": "24"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(=O)Cc1cccc(Br)c1.CCOC(C)=O.CN1CCCC1=O.N#C[Cu].[NH4+].[OH-]>>CCOC(=O)Cc1cccc(C#N)c1",
        "output": "531"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "CC(=O)O.CO.Cc1cccc(C)c1C=O.N#Cc1cc(-c2cccnc2)nn1-c1ccc(N)cc1.[BH3-]C#N.[Na+]>>Cc1cccc(C)c1CNc1ccc(-n2nc(-c3cccnc3)cc2C#N)cc1",
        "output": "359"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CN(C)C=O.O.O=C1CCC(=O)N1Br.c1ccc2c(c1)[nH]c1ccccc12>>Brc1ccc2[nH]c3ccccc3c2c1",
        "output": "4"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CC(=O)Nc1nc(C)c(-c2cc(S(=O)(=O)Cl)sc2Br)s1.CCN(CC)CC.CN(C(=O)OC(C)(C)C)C1CCNCC1.ClCCl>>CC(=O)Nc1nc(C)c(-c2cc(S(=O)(=O)N3CCC(N(C)C(=O)OC(C)(C)C)CC3)sc2Br)s1",
        "output": "798"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(C)[C@@H](NC(=O)OC(C)(C)C)C(=O)O.CC1(C)CNCCC1c1ccc(F)cc1>>CC(C)[C@@H](NC(=O)OC(C)(C)C)C(=O)N1CCC(c2ccc(F)cc2)C(C)(C)C1",
        "output": "146"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "C1CCOC1.COC(=O)c1ccc(C(F)(F)F)c(C2CC2)c1.Cl.[BH4-].[Li+]>>OCc1ccc(C(F)(F)F)c(C2CC2)c1",
        "output": "444"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "BrC(Br)(Br)Br.Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(CO)cc3)cc3c2cnn3C2CCCC2)c(=O)[nH]1.ClCCl.O.c1ccc(P(c2ccccc2)c2ccccc2)cc1>>Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(CBr)cc3)cc3c2cnn3C2CCCC2)c(=O)[nH]1",
        "output": "750"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "N#Cc1cnc2cnc(F)cc2c1Nc1ccc(F)c(Cl)c1.NCCCO>>N#Cc1cnc2cnc(NCCCO)cc2c1Nc1ccc(F)c(Cl)c1",
        "output": "810"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(=O)OCCc1cc(S(N)(=O)=O)c2c([N+](=O)[O-])cccc2c1Br.CO.C[O-].[Na+]>>NS(=O)(=O)c1cc(CCO)c(Br)c2cccc([N+](=O)[O-])c12",
        "output": "225"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CC(C)c1noc(N2CCC(CCCO)CC2)n1.Oc1ccc(Br)nc1>>CC(C)c1noc(N2CCC(CCCOc3ccc(Br)nc3)CC2)n1",
        "output": "547"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "C1CCOC1.C=[N+]=[N-].CCOCC.Nc1cc(C(F)(F)F)ccc1C(=O)O>>COC(=O)c1ccc(C(F)(F)F)cc1N",
        "output": "60"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "C1CCOC1.CC(=O)CCc1ccccc1.CC(C)[O-].CC(C)[O-].CC(C)[O-].CCO[SiH](OCC)OCC.[Na+].[OH-].[Y+3]>>CC(O)CCc1ccccc1",
        "output": "91"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CCN(C(C)C)C(C)C.FC1(F)CCNC1.O=C(NCC1(O)CCCC(F)(F)C1)c1c(Cl)ccc2nc(Cl)ccc12>>O=C(NCC1(O)CCCC(F)(F)C1)c1c(Cl)ccc2nc(N3CCC(F)(F)C3)ccc12",
        "output": "220"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CN(C)C=O.Cl.ClCc1cccnc1.O=[N+]([O-])c1ccc(O)cc1F.[H-].[Na+]>>O=[N+]([O-])c1ccc(OCc2cccnc2)cc1F",
        "output": "678"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "CCN(C)C(=O)c1cc(-c2ccc(CN)cn2)n(-c2ccc(OC)nc2)n1.CS(=O)(=O)Cl>>CCN(C)C(=O)c1cc(-c2ccc(CNS(C)(=O)=O)cn2)n(-c2ccc(OC)nc2)n1",
        "output": "493"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCO.COC(=O)CC(c1ccc(-c2ccc3cccnc3c2)cc1)N1CCC2(CC1)CN(C1CC1)C(=O)CO2.[Li+].[OH-]>>O=C(O)CC(c1ccc(-c2ccc3cccnc3c2)cc1)N1CCC2(CC1)CN(C1CC1)C(=O)CO2",
        "output": "88"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "BrP(Br)Br.Cc1ccccc1.OCc1cccc2ccccc12.c1ccncc1>>BrCc1cccc2ccccc12",
        "output": "300"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "C1CCOC1.CC(C)(C)[Si](C)(C)O[C@@H]1C[C@@H](CN)N(C(=O)OCc2ccc([N+](=O)[O-])cc2)C1.CC(Cl)C(=O)Cl.O.[Na+].[OH-]>>CC(Cl)C(=O)NC[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)OCc1ccc([N+](=O)[O-])cc1",
        "output": "45"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCN(CC)CC.CN(C)C=O.Cl.NCCCN1c2ccc(Cl)cc2CCc2cc(Cl)ccc21.O=S(=O)(Cl)c1ccc(Cl)cc1>>O=S(=O)(NCCCN1c2ccc(Cl)cc2CCc2cc(Cl)ccc21)c1ccc(Cl)cc1",
        "output": "43"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "CC(=O)c1cc(O)cc(OS(=O)(=O)C(F)(F)F)c1.CC(C)=O.CCOC(=O)CCCOc1cccc(CCCCCCBr)c1CCC(=O)OCC.CN(C)C=O.O=C([O-])[O-].[K+].[K+]>>CCOC(=O)CCCOc1cccc(CCCCCCOc2cc(OS(=O)(=O)C(F)(F)F)cc(C(C)=O)c2)c1CCC(=O)OCC",
        "output": "75"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCO.COC(=O)c1cccc([N+](=O)[O-])c1O.[Pd]>>COC(=O)c1cccc(N)c1O",
        "output": "481"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CO.COC(=O)c1nc(Cl)ccc1Br.[BH4-].[Na+]>>OCc1nc(Cl)ccc1Br",
        "output": "546"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "CCO.CN1CCC(C2C(=O)Nc3ccc([N+](=O)[O-])cc32)CC1.[Pd]>>CN1CCC(C2C(=O)Nc3ccc(N)cc32)CC1",
        "output": "1"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "C1COCCO1.CCOC(=O)C(CC(=O)OCc1ccccc1)(C(=O)OCC)n1cccc1.[C].[Pd]>>CCOC(=O)C(CC(=O)O)(C(=O)OCC)n1cccc1",
        "output": "186"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "CCCN.CCN(CC)CC.COc1cc2c(Oc3ccc(N)c(Cl)c3)ncnc2cc1OCc1ccccc1.ClC(Cl)Cl.O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>>CCCNC(=O)Nc1ccc(Oc2ncnc3cc(OCc4ccccc4)c(OC)cc23)cc1Cl",
        "output": "913"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccc(Cl)cc1B(O)O.Nc1nc(Cl)cc(NCCc2ccc(Cl)cc2)n1>>Cc1ccc(Cl)cc1-c1cc(NCCc2ccc(Cl)cc2)nc(N)n1",
        "output": "884"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN(C)C=O.COc1cc(CCCC(=O)O)c([N+](=O)[O-])cc1OC.O.Sc1ccccc1.[H-].[Na+]>>COc1cc([N+](=O)[O-])c(CCCC(=O)O)cc1O",
        "output": "402"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(C)(C)OC(=O)NCCc1ccc(Oc2ccc([N+](=O)[O-])cc2)cc1.CO.[Pd]>>CC(C)(C)OC(=O)NCCc1ccc(Oc2ccc(N)cc2)cc1",
        "output": "335"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "NC(=O)c1ccc(F)c(Br)c1.O=S(Cl)Cl>>N#Cc1ccc(F)c(Br)c1",
        "output": "374"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "C1CCNC1.CCN(C(C)C)C(C)C.CN(C)C(On1nnc2ccccc21)=[N+](C)C.CN1CCCC1=O.F[P-](F)(F)(F)(F)F.O=C(O)c1ccc2sc(-c3ccc(Cl)cc3O)nc2c1>>O=C(c1ccc2sc(-c3ccc(Cl)cc3O)nc2c1)N1CCCC1",
        "output": "44"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CCOC(C)=O.CCOc1cccc(C=O)c1O.CN(C)C=O.COS(=O)(=O)OC.O=C([O-])[O-].[K+].[K+]>>CCOc1cccc(C=O)c1OC",
        "output": "317"
    },
    {
        "instruction": "Identify the key structural motifs in the reactants and products that are indicative of a particular reaction class.",
        "input": "C1CCOC1.CCN(CC)CC.CCOC(C)=O.CCS(=O)(=O)Nc1ccc2[nH]cc(CCCO)c2c1.CS(=O)(=O)Cl.O=C([O-])O.[Na+]>>CCS(=O)(=O)Nc1ccc2[nH]cc(CCCOS(C)(=O)=O)c2c1",
        "output": "0"
    },
    {
        "instruction": "Classify the reaction by recognizing the specific type of bond formation or cleavage occurring during the transformation.",
        "input": "CCC(=O)Cl.NC1(c2ccc(Br)cc2)CC1.c1ccncc1>>CCC(=O)NC1(c2ccc(Br)cc2)CC1",
        "output": "206"
    },
    {
        "instruction": "Based on the presence of specific catalysts or reagents, assign the reaction to the appropriate class.",
        "input": "CCOC(C)=O.CN(C)C=O.CN1CCOCC1.Clc1ccc2c(c1)SCc1cccnc1C2N1CCNCC1.O.O=C(O)Cc1ccncc1.On1nnc2ccccc21>>O=C(Cc1ccncc1)N1CCN(C2c3ccc(Cl)cc3SCc3cccnc32)CC1",
        "output": "146"
    },
    {
        "instruction": "Analyze the stereochemical changes in the reaction and use them to determine the corresponding reaction class.",
        "input": "COc1ccc(F)cc1Oc1cc(F)c(C#N)cc1F.CS(C)=O.O=C([O-])[O-].OO.[K+].[K+]>>COc1ccc(F)cc1Oc1cc(F)c(C(N)=O)cc1F",
        "output": "180"
    },
    {
        "instruction": "Identify the main reaction type (e.g., substitution, addition, elimination) and use it to classify the reaction into a specific template class.",
        "input": "CCOC(=O)C(Cc1ccc2c(c1)OC(F)(F)C(F)(F)O2)C(O)c1ccc(F)cc1.CO.[Na+].[OH-]>>O=C(O)C(Cc1ccc2c(c1)OC(F)(F)C(F)(F)O2)C(O)c1ccc(F)cc1",
        "output": "7"
    },
    {
        "instruction": "Based on the type of heteroatoms involved in the reaction, predict the most likely reaction class from the predefined set.",
        "input": "CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCN(CC(C)=O)CC3)cc21.CO.Cl.ClCCl.NO.O.O=C([O-])O.[Na+]>>CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCN(CC(C)=NO)CC3)cc21",
        "output": "86"
    },
    {
        "instruction": "Given a chemical reaction, classify it into one of the predefined reaction classes from the USPTO 1K TPL dataset.",
        "input": "C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12.CC(=O)OC(C)=O.CN(C)c1ccncc1.ClC(Cl)Cl.c1ccncc1>>C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](OC(C)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12",
        "output": "254"
    },
    {
        "instruction": "Based on the reactants and products, predict the most likely reaction class that describes the transformation.",
        "input": "CC(C)C[C@H](O)C(=O)O.CCN=C=NCCCN(C)C.CN1CCOCC1.COC(=O)[C@@H](N)CC(C)C.Cl.ClCCl.On1nnc2ccccc21>>COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)CC(C)C",
        "output": "129"
    },
    {
        "instruction": "Analyze the structural changes between the reactants and products, and assign the reaction to the appropriate class.",
        "input": "C#CCCCC(=O)O.C1COCCN1.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.Cl.ClCCl>>C#CCCCC(=O)N1CCOCC1",
        "output": "146"
    },
    {
        "instruction": "Identify the key reactive sites in the given reaction and use them to determine the corresponding reaction class.",
        "input": "Cc1ccoc1C(=O)NCc1ccccc1.Cc1ccsc1C(=O)NCc1ccc(F)cc1.O=C1CCC(=O)N1Br>>Cc1cc(Br)sc1C(=O)NCc1ccc(F)cc1",
        "output": "807"
    },
    {
        "instruction": "Classify the reaction into one of the template classes by recognizing the characteristic patterns of atom rearrangements.",
        "input": "CN1CCNCC1.CS(C)=O.O=C([O-])[O-].O=[N+]([O-])c1cccc(F)c1.[K+].[K+]>>CN1CCN(c2cccc([N+](=O)[O-])c2)CC1",
        "output": "26"
    },
    {
        "instruction": "Determine the reaction class based on the specific combination of reactants, reagents, and products present.",
        "input": "CC(=O)O.CC(=O)[O-].Nc1cccc(O)c1.O=C(Br)CBr.[Na+]>>O=C(CBr)Nc1cccc(O)c1",
        "output": "442"
    },
    {
        "instruction": "Assign the reaction to one of the classes by identifying the main functional group transformations occurring in the reaction.",
        "input": "CO.O=C(O)C(=O)C(=O)Nc1cccc([N+](=O)[O-])c1.[Pd]>>Nc1cccc(NC(=O)C(=O)C(=O)O)c1",
        "output": "1"
    },
    {
        "instruction": "Based on the reaction's atom-mapping, predict the reaction class that best represents the chemical transformation.",
        "input": "FC(F)Oc1ncc(CBr)cc1Br.OB(O)c1cccc(Cl)c1>>FC(F)Oc1ncc(CBr)cc1-c1cccc(Cl)c1",
        "output": "833"
    },
    {
        "instruction": "Analyze the reaction mechanism and use it to classify the reaction into one of the predefined template classes.",
        "input": "CN(C)C=O.CN1CC(C)(C2=CCCCC2)CN(CC(O)c2ccccc2)C1=O.ClCCl.O.O=[Cr](=O)([O-])O[Cr](=O)(=O)[O-].c1cc[nH+]cc1.c1cc[nH+]cc1>>CN1CC(C)(C2=CCCCC2)CN(CC(=O)c2ccccc2)C1=O",
        "output": "32"
    }
]